id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266521-vovas81d	Yokobayashi, Yohei	Aptamer-based and aptazyme-based riboswitches in mammalian cells	2019-06-22		.txt	text/plain	3228	155	43	In this report, recent advances in synthetic riboswitches that function in mammalian cells are reviewed focusing on the regulatory mechanisms they exploit such as mRNA degradation, microRNA processing, and programmed ribosomal frameshifting. In this report, recent advances in synthetic riboswitches that function in mammalian cells are reviewed focusing on the regulatory mechanisms they exploit such as mRNA degradation, microRNA processing, and programmed ribosomal frameshifting. While the ribozyme was not specifically regulated by a small molecule via an aptamer, this work paved the way for the subsequent riboswitches that employ allosterically regulated ribozymes (aptazymes) embedded in the 5 0 and/or 3 0 UTR to chemically regulate gene expression in mammalian cells (Figure 1a ) [13] [14] [15] [16] . A new mode of engineered RNA-based gene regulation in mammalian cells was demonstrated by controlling the accessibility of a miRNA target site by aptamer-ligand interaction	./cache/cord-266521-vovas81d.txt	./txt/cord-266521-vovas81d.txt