id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267012-45tre8rn	Premanand, Balraj	Baculovirus Surface Display of Immunogenic Proteins for Vaccine Development	2018-05-31		.txt	text/plain	11102	530	34	While recombinant baculoviral vector expressing both VSV-G and influenza HA was shown to evoke both humoral and cellular immune responses and provided effective protection against lethal virus challenge in mouse and chicken hosts [26] , the high cytotoxicity of VSV-G protein [98] and its immediate inactivation by serum complement systems impedes the use of the element in a vaccine delivery vehicle [99] . The vaccine showed successful HA expression on its envelope, and mice vaccination studies showed that both the live and adjuvanted with inactive form of recombinant baculovirus induced HA-specific antibody responses and offered complete protection against lethal viral infection [101] . Moreover, recombinant baculovirus with CMV-polyhedrin dual promoter for expressing chimeric HA of H9N2 was shown to efficiently express HA in both mammalian and insect cells, induce strong immune response, and provide 100% protection against lethal H9N2 viral challenge in mice, unlike other vaccine candidates observed [34] .	./cache/cord-267012-45tre8rn.txt	./txt/cord-267012-45tre8rn.txt