id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267166-ecmayzr6	Savarin, Carine	Distinct Gene Profiles of Bone Marrow-Derived Macrophages and Microglia During Neurotropic Coronavirus-Induced Demyelination	2018-06-11		.txt	text/plain	7736	371	39	While gene expression in CNS infiltrating BMDM was upregulated early following infection and subsequently sustained, microglia expressed a more dynamic gene profile with extensive mRNA upregulation coinciding with peak demyelination after viral control. This study takes advantage of the distinct tissue environments established during EAE and JHMV infection to characterize temporal alterations in gene expression profiles of BMDM versus microglia in a Th1 biased demyelination model. We next evaluated effector functions of BMDM versus microglia associated with JHMV-induced demyelination by comparing gene expression profiles using nCounter analysis of mRNA isolated from purified BMDM and microglia of infected CX3CR1 GFP/+ CCR2 RFP/+ mice. Using a similar approach with Nanostring analysis as in EAE, the present study used gene expression profiling to characterize both BMDM and microglia myeloid functions at various times post JHMV infection.	./cache/cord-267166-ecmayzr6.txt	./txt/cord-267166-ecmayzr6.txt