id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267965-84sotgds	Noll, Kelsey E.	The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions	2019-04-10		.txt	text/plain	9369	407	39	While advances in human genetic analysis have led to the identification of several host genes that regulate pathogen susceptibility in humans (Newport and Finan, 2011) , much of our understanding of how specific genes affect infectious disease pathogenesis in mammals has come from studies using mouse models (Masopust et al., 2017) . In contrast to the approaches discussed above, researchers have also studied the role of natural genetic variants by leveraging differential phenotypes across inbred strains, using classical genetic breeding strategies to identify pathogen susceptibility genes such as Oas1b, immune cell activating receptor Ly49H, and large interferon-induced GTPase Mx1 (Casanova et al., 2002) . Due to higher genetic diversity with novel allele combinations and epistatic interactions, the CC yields more phenotypic variation and extreme phenotypes than classical GRPs. The selection of founder strains and the breeding design, as well as higher levels of recombination, result in lower levels of long-range disequilibrium and population structure than classical GRPs, allowing for higher resolution quantitative trait locus (QTL) mapping (Iraqi et al., 2012; Threadgill et al., 2002) .	./cache/cord-267965-84sotgds.txt	./txt/cord-267965-84sotgds.txt