id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269443-l8wj6dsy	Özdemir, Rabia Bilge Özgül	The investigation of immunomodulatory effects of adipose tissue mesenchymal stem cell educated macrophages on the CD4 T cells	2019-04-30		.txt	text/plain	6805	362	54	In this study, we compared the immunomodulatory effects on the CD4 T cells of M1, M2a and M2c macrophages with the macrophages that directly and indirectly cultured with MSCs. We analyzed the changes in CD14, CD64, CD80, CD163 and CD200R expression to evaluate macrophage phenotypes, and the changes in CD4, IFN-g, IL-4, IL-17a and FoxP3 expression to evaluate T helper subsets using the FACS method. As a result, according to our data, the interactions between MSCs and macrophages may lead to differentiation of macrophage cells into an immunosuppressive phenotype, and these macrophages may suppress the T lymphocyte subgroups at least as effectively as MSCs. However, our data obtained from in vitro experiments should be supported by future in vivo studies. We observed that the CD14 expressions of the MEM-D and MEM-ID groups showed a similar pattern to the M2c group, suggesting that MSCs can differentiate macrophage cells into the M2c-like phenotype through direct or indirect effects.	./cache/cord-269443-l8wj6dsy.txt	./txt/cord-269443-l8wj6dsy.txt