id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269957-vd9ctqro	Hua, Chen	The Underlying Mechanism of 3-Hydroxyphthalic Anhydride-Modified Bovine Beta-Lactoglobulin to Block Human Papillomavirus Entry Into the Host Cell	2019-09-26		.txt	text/plain	6473	298	58	We have previously demonstrated that 3-hydroxyphthalic anhydride (3HP)-modified bovine beta-lactoglobulin (3HP-β-LG) is highly effective in inhibiting entry of pseudovirus (PsV) of highand low-risk human papillomavirus (HPV) into the target cell. In 2012, Jiang's group reported that 3HP-modified bovine beta-lactoglobulin (3HPβ-LG) could also inhibit entry into the target cell of the pseudovirus (PsV) of non-enveloped virus, HPV (high-risk HPV16 and HPV18, and low-risk HPV6) (Lu et al., 2013) . As we proposed before, 3HP-β-LG inhibited HPV PsV entry into the target cell possibly through the binding of the negatively charged residues in 3HP-β-LG with the positively charged residues in a protein on the surface of the viral particle, thereby blocking the interaction between viral protein and receptor on the target cell (Lu et al., 2013) . These results suggested that 3HP-β-LG may bind to the positively charged sites in the C-terminal region of L1 protein on the HPV surface to block the interaction between the viral particle and cell receptor.	./cache/cord-269957-vd9ctqro.txt	./txt/cord-269957-vd9ctqro.txt