id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282251-r4on3lpr	Veggiani, Gianluca	Emerging drug development technologies targeting ubiquitination for cancer therapeutics	2019-03-07		.txt	text/plain	11388	580	41	Within the span of 20 years, high-throughput technologies further advanced to include feats in protein engineering such as proteolysis-targeting chimeras (PROTACs) derived from the ubiquitination pathway (Zhou, Bogacki, McReynolds, & Howley, 2000) , streamlined phage display approaches that include Ub variants (UbV) to target protein-protein interactions in the UPS (Brown et al., 2016; Ernst et al., 2013; Ernst & Sidhu, 2013; Gabrielsen et al., 2017; Ordureau et al., 2018; Zhang et al., 2016; Zhang et al., 2017; Zhang et al., 2017; Zhang & Sidhu, 2018) and cell-based pharmacological HTS assays to enhance oncolytic virus cancer-cell-killing efficiency through viral sensitizer screens (Bourgeois-Daigneault et al., 2016; Diallo et al., 2010) (Fig. 2) .	./cache/cord-282251-r4on3lpr.txt	./txt/cord-282251-r4on3lpr.txt