id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282322-ywwqnw74	Tomar, Jasmine	Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge	2018-10-09		.txt	text/plain	6732	349	49	Our previous study in chickens has shown that inhalation of a non-adjuvanted dry powder influenza vaccine formulation during normal breathing results in partial protection against lethal influenza challenge. Upon passive inhalation of dry influenza vaccine formulations in an optimized set-up, BLP and Advax/BLP adjuvanted formulations induced significantly higher systemic immune responses than the non-adjuvanted formulation. In a previous study, we have shown that pulmonary immunization by dispersion of a dry powder influenza vaccine directly at the syrinx of chickens (active administration) was able to completely protect these animals against lethal viral challenge [11] . For this, we initially tested whether (a) BLP or Advax could be co-formulated with influenza vaccine into dry powder formulations that are suitable for pulmonary immunization; (b) the adjuvants have the potential to boost systemic and mucosal immune responses to influenza; (c) passive administration with either non-adjuvanted or adjuvanted influenza formulations would protect chickens against a lethal HPAIV challenge.	./cache/cord-282322-ywwqnw74.txt	./txt/cord-282322-ywwqnw74.txt