id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284112-jobd5s4l	Tulgar, Serkan	Possible Old Drugs for Repositioning in COVID-19 Treatment: Combating Cytokine Storms from Haloperidol to Anti-interleukin Agents	2019-06-01		.txt	text/plain	510	39	50	title: Possible Old Drugs for Repositioning in COVID-19 Treatment: Combating Cytokine Storms from Haloperidol to Anti-interleukin Agents Until recently, haloperidol was the most commonly used agent in the prevention or treatment of delirium that developed in intensive care units (9, 10) . (11) reported that haloperidol decreased mortality of patients on mechanical ventilation and hypothesized that this was due to its effect on lowering cytokine levels and, therefore, aided in preventing a cytokine storm associated with severe disease. However, we recommend that haloperidol be considered as an option to treat patients who develop agitation during the treatment process or agitation/delirium during the intensive care treatment process and continue to be administered routinely until proven otherwise. In addition to clinical studies (NCT04330638) related to the use of anti-IL agents such as anakinra, siltuximab, and tocilizumab in combating cytokine storms, studies are also being conducted with old drugs (NCT04304313) such as sildenafil, used indirectly outside of their indications.	./cache/cord-284112-jobd5s4l.txt	./txt/cord-284112-jobd5s4l.txt