id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285121-3cjr1rol	Chan, Marion M.	Targeting cancer stem cells with dietary phytochemical - Repositioned drug combinations	2018-10-01		.txt	text/plain	8604	521	43	In this review, we advocate the development of a novel approach, namely combination therapy by incorporating both phytochemicals and repositioned drugs to target CSCs. We cover select dietary phytochemicals (curcumin, resveratrol, EGCG, genistein) and repurposed drugs (metformin, niclosamide, thioridazine, chloroquine). For CSC targeting, we recommend four dietary phytochemicals (curcumin, resveratrol, EGCG, genistein) and four repurposed drugs (metformin, niclosamide, thioridazine, chloroquine). Furthermore, five (curcumin, resveratrol, EGCG, genistein, metformin) are listed by an international task force of 180 clinicians and scientists of "The Halifax Project", with dedicated objective to "explore the concept of a low-toxicity 'broad-spectrum' therapeutic approach that could simultaneously target many key pathways and mechanisms" for cancer treatment [1] . EGCG works in combination with other phytochemicals and conventional drugs to enhance anti-cancer effects, targeting bulk cancer cells and CSCs [69] . We found that thioridazine and curcumin may act synergistically in inhibiting spheroids from ovarian cancer cells, with the combination more effective than either compound alone.	./cache/cord-285121-3cjr1rol.txt	./txt/cord-285121-3cjr1rol.txt