id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289861-i6bfuvq1	Macdonald-Laurs, Emma	CSF neopterin, a useful biomarker in children presenting with influenza associated encephalopathy?	2018-09-28		.txt	text/plain	4246	272	46	title: CSF neopterin, a useful biomarker in children presenting with influenza associated encephalopathy? Severe neurological complications from seasonal influenza, including influenza-associated encephalopathy/encephalitis (IAE), cause considerable morbidity and mortality in healthy children, and those with pre-existing neurological disease. We identified children aged 0e14 years, with evidence of influenza and associated severe neurological disease including status epilepticus or moderate to severe encephalopathy, admitted to two paediatric hospitals which comprise the Sydney Children's Hospital Network, the largest paediatric network in Australia. In this case series we observed two groups of children who presented with severe influenza related neurological disease. Further studies of IAE are required to evaluate whether significant elevations of CSF neopterin, particularly in combination with diffusion restriction and other MRI changes, could predict short and long-term outcome. Given the severity of influenza associated neurological complications, we recommend a "treat and test" approach to the use of oseltamivir in children presenting with acute encephalopathy/encephalitis during the influenza season.	./cache/cord-289861-i6bfuvq1.txt	./txt/cord-289861-i6bfuvq1.txt