id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290833-m0wodqr3	Yuan, Lvfeng	Synthetic surfactin analogues have improved anti-PEDV properties	2019-04-11		.txt	text/plain	3580	195	51	In this study, 10 surfactin analogues were obtained by chemical synthesis and evaluated to determine their anti-PEDV activities, hemolytic activities, and critical micelle concentrations. The production of designer surfactins, made by changing the number and composition of amino acids and fatty acids has proven to be an effective strategy for screening large numbers of lipopeptides for biological activity, but most current research focuses on their anticancer [4] , antimicrobial [5] and insulin delivery [6] properties but not on their antiviral potential. Time of addition assays were performed to determine whether the SLP5 exerts its anti-PEDV effect at the same stage during infection as surfactin. As expected for a normal component of the cell membrane, DEPE did not affect PEDV replication at any stage, while SLP5 and surfactin exhibited antiviral activity at specific stages. SLP5 also has two fewer hydrophobic amino acids than surfactin, this reduces the cost of synthesis while having little effect on antiviral activity.	./cache/cord-290833-m0wodqr3.txt	./txt/cord-290833-m0wodqr3.txt