id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291041-3mqs7mj1	Franco-Martínez, Lorena	Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study	2018-09-24		.txt	text/plain	5800	266	38	Bioinformatics' analysis revealed that saliva reflects the involvement of different pathways in PVE such as catalytic activity and binding, and indicates antimicrobial humoral response as a pathway with a major role in the development of the disease. Of the 90 differentially expressed proteins between survival and control groups, the proteins most down-regulated in the survival group were cathelicidin antimicrobial peptide (CAMP), rho-GDP dissociation inhibitor beta (ARHGDIB), apolipoprotein A-1 (APO-A1), neutrophil elastase (ELANE), matrix metalloproteinase-9 (MMP9), EF-hand domain containing protein D2 (EFHD2), CD177 antigen (CD177), plastin-2 (LCP1), retinol binding protein 4 (RBP4), and maltase-glucoamylase intestinal (MGAM). Overall changes in protein expression in saliva from dogs with parvovirosis obtained in this study by high-resolution quantitative proteomic analysis suggested alterations in coagulation and inflammation systems, which are closely related pathways since the activation of one mechanism may lead to the activation of the other [30] . The two most down-regulated proteins in the dogs with parvovirosis that survived, cathelicidin antimicrobial peptide (CAMP) and Rho-GDP dissociation inhibitor beta (ARHGDIB), have protective role against infections and are involved in the inflammatory response.	./cache/cord-291041-3mqs7mj1.txt	./txt/cord-291041-3mqs7mj1.txt