id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296992-2vp35fwv	Simonsen, Lone	Using Clinical Research Networks to Assess Severity of an Emerging Influenza Pandemic	2018-05-08		.txt	text/plain	3968	187	44	We retrospectively investigated how to use data from the International Network for Strategic Initiatives in Global HIV Trials, a global clinical influenza research network, to make more accurate case fatality ratio (CFR) estimates early in a future pandemic, an essential part of pandemic response. Since 2009, INSIGHT has undertaken 2 cohort studies-1 outpatient (FLU002) and 1 inpatient (FLU003)-specifically to address gaps in clinical research on the emerging influenza pandemic, including factors linked to disease progression and severe outcomes [24] . To underscore the importance of having baseline data, we compared the estimated pH1N1 clinical severity to that of seasonal influenza types and subtypes and noninfluenza respiratory patients in the post-pandemic period (2012) (2013) (2014) (2015) . Our analysis combining data from inpatient and outpatient INSIGHT cohorts demonstrates how preestablished global research networks could immediately begin rigorous studies to estimate the CFR, a key parameter of clinical severity of an emerging pandemic.	./cache/cord-296992-2vp35fwv.txt	./txt/cord-296992-2vp35fwv.txt