id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297669-22fctxk4	Proudfoot, Chris	Genome editing for disease resistance in pigs and chickens	2019-06-25		.txt	text/plain	4555	237	44	The virus was thought to attach to CD169 to be taken up into the cells; however, genome-edited pigs lacking CD169 were not resistant to PRRSV infection (Prather et al., 2013) . Chicken somatic cell lines have been edited to introduce changes to this gene-conferring resistance to avian leucosis virus in vitro (Lee et al., 2017) . However, as the example for avian influenza shows, host genes play an important role in other steps of the pathogen replication cycle and also provide editing targets for disease resilience or resistance. Genome editing allows integration of the disease-resistance trait into a wider selection of pigs, ensuring genetic variability and maintenance of desirable traits. (D) Resistance genes may be identified in laboratory research but not in highly bred lines, making integration into those productive animals only possible using genome editing. She employs genome editing and genetic selection to generate animals genetically resistant to viral disease.	./cache/cord-297669-22fctxk4.txt	./txt/cord-297669-22fctxk4.txt