id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-298032-3zlu8g8y	Nan, Yuchen	Antisense Phosphorodiamidate Morpholino Oligomers as Novel Antiviral Compounds	2018-04-20		.txt	text/plain	10577	524	46	An earlier study showed that a 22mer PPMO targeting the translation start site region of EBOV VP35 positive-sense RNA exhibited sequence-specific, time-and dose-dependent inhibition of EBOV replication in cultured cells (Enterlein et al., 2006) . However, PPMO targeting conserved internal ribosome entry site (IRES) sequences have been shown to be highly effective in protecting cultured cells against infection by human rhinovirus type 14, coxsackievirus type B2, and poliovirus type 1 (PV1) (Stone et al., 2008) , with reduction of PV1 titers by up to 6 log10. In this study, virus replication in MDCK cells was significantly inhibited by three PPMO targeting either the translation start site region of PB1 or NP mRNA or the 3 -terminal region of NP viral RNA (vRNA). Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2	./cache/cord-298032-3zlu8g8y.txt	./txt/cord-298032-3zlu8g8y.txt