id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304488-t2jm1n77	Severance, Emily G.	Autoimmune phenotypes in schizophrenia reveal novel treatment targets	2018-09-30		.txt	text/plain	13993	658	34	We will then discuss the autoimmune phenotype of schizophrenia in terms of risk factors for disease including the role of infection, a peripheral and central inflammatory state, gut dysbioses and the presence of autoantibodies. We will integrate our discussion with mechanisms that contribute to relevant CNS pathologies, including behavioral indices such as severity of psychiatric symptoms and cognitive deficits and biochemical indices such as complement pathway dysfunction and autoimmune-related neurotransmitter receptor hypofunction. In most cases, the source of this inflammation in these studies is not known, but it is evident in the form of pro-and anti-inflammatory cytokine dysregulation, disrupted tryptophan and kynurenine metabolism, exposure to microbial pathogens and antigens, food hypersensitivities, complement activation, post-mortem pathologies and brain imaging.	./cache/cord-304488-t2jm1n77.txt	./txt/cord-304488-t2jm1n77.txt