id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304807-j2k1oel2	Herrera-Rodriguez, José	Inactivated or damaged? Comparing the effect of inactivation methods on influenza virions to optimize vaccine production	2019-03-14		.txt	text/plain	5758	274	43	The properties of the viral formulation, such as successful inactivation, preservation of hemagglutinin (HA) binding ability, fusion capacity and the potential to stimulate a Toll-like receptor 7 (TLR7) reporter cell line were then assessed and compared to the properties of the untreated virus. Hemagglutination and fusion ability were highly affected by those treatments that conferred higher inactivation, with BPL-treated virus binding and fusing at a lower degree compared to FA-inactivated samples. Our aim was to compare the effects of these procedures on the key properties, namely residual infectivity, receptor binding, fusion, and Toll-like receptor 7 (TLR7) mediated activation of innate immune mechanisms, and to determine whether these effects are similar for different virus strains. Previous studies show that BPL is capable of complete inactivation of influenza virus; however, the effectivity might vary depending on the incubation time and temperature.	./cache/cord-304807-j2k1oel2.txt	./txt/cord-304807-j2k1oel2.txt