id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304876-txaoz7oh	Jordan, Paul C	Nucleosides for the treatment of respiratory RNA virus infections	2018-03-21		.txt	text/plain	10962	654	46	42 Viral polymerase: An important molecular target for antiviral therapy Nucleoside analogs represent one of the dominant classes of antiviral agents due to their widespread use against the common chronic infections caused by human immunodeficiency virus (HIV), hepatitis B virus, and herpesviruses. 43 After being metabolized by host kinases to their triphosphate form, antiviral nucleotides compete with natural nucleoside triphosphates (NTPs) to bind to the active site of viral polymerases and alter DNA or RNA synthesis. 122 However, the results summarized here indicate that nucleoside analogs targeting the viral RNA polymerase of rhinovirus, EV71, and other enteroviruses have the potential to be efficacious in preclinical animal models, providing a rationale to conduct human studies with safer molecules sharing the same mode of action. Structure and functional analysis of the RNA-and viral phosphoprotein-binding domain of respiratory syncytial virus M2-1 protein	./cache/cord-304876-txaoz7oh.txt	./txt/cord-304876-txaoz7oh.txt