id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305602-yzc4bosn	Llano, Manuel	Chapter Seven Defining Pharmacological Targets by Analysis of Virus–Host Protein Interactions	2018-12-31		.txt	text/plain	5909	324	41	This higher than expected connectivity suggests that the direct interactions of viral proteins with host factors allow the access of the virus to cellular complexes. For example, in a TAP-MS experiment were mapped 3787 complex associations between 54 viral proteins from different viruses and 1079 host proteins (Rozenblatt-Rosen et al., 2012) , highlighting the high degree of connectivity of the interacting proteins. As discussed above, some of the host factors predicted, by the combined transcriptional profiling and in silico analyses, to interact with host proteins implicated in direct binary contacts with influenza proteins (Y2H interactors) were demonstrated to influence viral replication in functional screenings (Shapira et al., 2009 ). Most of the small molecules interfering with PPIs bind directly to the implicated surfaces of interactions (orthosteric modulators) by targeting hot spot residues or by molecular mimicry of elements of secondary structures (Arkin et al., 2014; Basse et al., 2016; Fry, 2006; Wells & McClendon, 2007; Yin & Hamilton, 2005) .	./cache/cord-305602-yzc4bosn.txt	./txt/cord-305602-yzc4bosn.txt