id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314340-ltx4w9zh	Zhu, Liqian	The Involvement of Histone H3 Acetylation in Bovine Herpesvirus 1 Replication in MDBK Cells	2018-09-27		.txt	text/plain	6002	282	44	During bovine herpesvirus 1 (BoHV-1) productive infection in cell cultures, partial of intranuclear viral DNA is present in nucleosomes, and viral protein VP22 associates with histones and decreases histone H4 acetylation, indicating the involvement of histone H4 acetylation in virus replication. In this study, we demonstrated that BoHV-1 infection at the late stage (at 24 h after infection) dramatically decreased histone H3 acetylation [at residues K9 (H3K9ac) and K18 (H3K18ac)], which was supported by the pronounced depletion of histone acetyltransferases (HATs) including CBP/P300 (CREB binding protein and p300), GCN5L2 (general control of amino acid synthesis yeast homolog like 2) and PCAF (P300/CBP-associated factor). Indeed, 5 µM of AA treatment could inhibit histone H3 acetylation as demonstrated by the reduced levels of H3K9ac relative to the control, but AA increased the levels of H3K9ac in the context of virus infection in comparison to the mock treated but infected cells ( Figure 3E ,F).	./cache/cord-314340-ltx4w9zh.txt	./txt/cord-314340-ltx4w9zh.txt