id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314867-qg3hl5ft	Yoon, Ji Hye	Study on the 2‐Phenylchroman‐4‐One Derivatives and their anti‐MERS‐CoV Activities	2019-07-28		.txt	text/plain	1209	71	60	Bavachin and bavachinin showed good anti-MERS-CoV activities of 2.9 and 7.9 μM respectively by phenotypic cellular screening with vero cell. Total 12 compounds of bavachinin derivatives in four core structures were evaluated to figure out their anti-MERS-CoV activity and cell-cytotoxicity by cellular phenotypic screening method as shown in Table 1 . The further alkylations of phenolic OH of 1a with isopropyl and benzyl group decreased the anti-MERS activities (Entry 3 and 4 in Table 1 ). Interestingly, O-isopropyl Note and O-benzyl derivatives (2c and 2d, respectively) showed similar activity with 2a (non-substituted) better than 2b (Omethylated), but the cytotoxicity for vero cell also increased. As a conclusion, a series of 2-phenylchroman-4-one derivatives were synthesized for the chemical modifications of bavachin, and they exhibited anti-MERS activities in vero cell. We expect the study on bavachin derivatives can contribute to the development of anti-MERS drug.	./cache/cord-314867-qg3hl5ft.txt	./txt/cord-314867-qg3hl5ft.txt