id author title date pages extension mime words sentences flesch summary cache txt cord-318238-56x5q7f6 Astudillo, Patricio Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients 2019-10-23 .txt text/plain 4634 260 45 METHODS: A total of 682 infants suffering from bronchiolitis, categorized based on the final clinical outcome as mild or severe, were genotyped for IL28B SNPs rs12979860 and rs8099917. CONCLUSION: SNPs rs12979860 and rs8099917 correlate with the severity of bronchiolitis and display a sex bias, where GG rs8099917 and TT rs12979860 genotypes are associated with a mild disease in girls but not in boys. Results revealed no correlation between the severity of bronchiolitis and viral coinfection but being homozygotes for the minor allele (G) for SNP rs8099917 linked with a mild bronchiolitis among hospitalized patients (OR: 0.55 (95% CI: 0.32-0.95), p = 1; Table 3 ). No differences were observed in sex distribution, gestational age, birth weight, type of delivery, nutritional status, maternal pregnancy diseases, and personal history of atopy ( Fig. 3 Correlation between clinical severity of global bronchiolitis or RSV bronchiolitis and IL28B SNPs rs12979860 and rs8099917. ./cache/cord-318238-56x5q7f6.txt ./txt/cord-318238-56x5q7f6.txt