id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328940-8vtcochx	Lee, Jeong Yoon	Bacterial RecA Protein Promotes Adenoviral Recombination during In Vitro Infection	2018-06-20		.txt	text/plain	7979	407	39	By analysis of known recombination hot spots across 38 human adenovirus genomes in species D (HAdV-D), we identified nucleotide sequence motifs similar to bacterial Chi sequences, which facilitate homologous recombination in the presence of bacterial Rec enzymes. We speculate that free Rec proteins present in gastrointestinal secretions upon bacterial cell death facilitate the evolution of human adenoviruses through homologous recombination, an example of viral commensalism and the complexity of virus-host interactions, including regional microbiota. Our computational analysis of similar GC content transitions across whole HAdV-D genomes showed comparable patterns of GC/AT transition at predicted recombination hot spots around hypervariable gene segments in the three major capsid genes-the same segments that constitute the molecular identity of each virus (14, 19, (41) (42) (43) -including the region containing Chi AD immediately 5= to penton base HVL2 (see Fig. S1 and Table S1 in the supplemental material).	./cache/cord-328940-8vtcochx.txt	./txt/cord-328940-8vtcochx.txt