id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340501-bcaerchf	van der Heden van Noort, Gerbrand J.	How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling	2018-09-04		.txt	text/plain	6371	296	49	In this chapter, we will discuss the current state-of-the-art of activity-based probes, reporter substrates, and other relevant tools based on Ub as recognition element, to study the enzymes involved in the complex system of ubiquitination. state-of-the-art of activity-based probes, reporter substrates, and other relevant tools based on Ub as recognition element, to study the enzymes involved in the complex system of ubiquitination. A panel of all seven isopeptide-linked diUb probes can be constructed and used to covalently capture the active site cysteine of the DUB showing its reactivity and preference toward certain linkage types. Unraveling the complexity of this, highly sophisticated system is aided greatly by the development of (activity-based) probes reporting on the dynamics and structural mechanisms used by activating enzymes, ligases, and proteases counteracting the buildup of (poly)-ubiquitinated substrates.	./cache/cord-340501-bcaerchf.txt	./txt/cord-340501-bcaerchf.txt