id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341272-mw6ujjrk	Loré, Nicola Ivan	The impact of host genetic background in the Pseudomonas aeruginosa respiratory infections	2018-06-12		.txt	text/plain	4659	226	36	The relevance of individual genetic variations to Pseudomonas aeruginosa infection is emerging in several respiratory illnesses of different etiologies including cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), or bronchiectasis. Studies with different inbred mouse strains support the contribution of the host genetic background to predispose the animals to chronic infection and different degrees of disease severity due to a different immunoreactivity to pathogens (Table 1 ). Recently, we exploited the agar-beads mouse model of long-term chronic lung infection, refined and characterized in C57Bl/6NCrl , in five phylogenetically different inbred strains of mice to identify deviant disease phenotypes and to dissect the cell-mediated immunity . Early immune response in susceptible and resistant mice strains with chronic Pseudomonas aeruginosa lung infection determines the type of T-helper cell response The host genetic background defines diverse immune-reactivity and susceptibility to chronic Pseudomonas aeruginosa respiratory infection	./cache/cord-341272-mw6ujjrk.txt	./txt/cord-341272-mw6ujjrk.txt