id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343596-w9rw2wak	Burns, Amy L	Targeting malaria parasite invasion of red blood cells as an antimalarial strategy	2019-02-11		.txt	text/plain	11854	608	40	Red blood cell invasion requires a co-ordinated series of protein/protein interactions, protease cleavage events, intracellular signals, organelle release and engagement of an actin-myosin motor, which provide many potential targets for drug development. In this review, we discuss red blood cell invasion as a drug target and highlight a number of approaches for developing antimalarials with invasion inhibitory activity to use in future combination therapies. One leading drug target involved in signalling during RBC invasion is calcium dependent protein kinase 1 (CDPK1), a parasite kinase not present in the human host (Harper and Harmon 2005) that has key roles in microneme secretion, activation of the actin-myosin motor and other processes required for RBC invasion (Fig. 2b-e) (Green et al. Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum	./cache/cord-343596-w9rw2wak.txt	./txt/cord-343596-w9rw2wak.txt