id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-344227-rdlinzrn	Gralinski, Lisa E.	Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis	2018-10-09		.txt	text/plain	6557	309	43	As with the outcome of human infection, intranasal infection of C57BL/6J mice with mouse-adapted SARS-CoV results in high-titer virus replication within the lung, induction of inflammatory cytokines and chemokines, and immune cell infiltration within the lung. Mice deficient in C3 (C3 -/-), the central protein of the complement signaling pathway, were protected from SARS-CoV-induced weight loss and had reduced pathology, improved respiratory function, and lower levels of inflammatory cytokines/chemokines in the lung and periphery. Immunohistochemical staining revealed that SARS-CoV MA15 infection induced complement deposition in the lung (Fig. 4) , similar to that associated with pathogenesis in Ross River virus-infected mice (41) and some influenza virus infections (34) , and it is likely that complement deposition contributes to pulmonary disease and inflammatory cell recruitment.	./cache/cord-344227-rdlinzrn.txt	./txt/cord-344227-rdlinzrn.txt