id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345044-2fez1gu0	Proenca‐Modena, José Luiz	Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children	2019-03-18		.txt	text/plain	3198	164	40	The present paper reports a 3‐year cross‐sectional hospital‐based study aimed at detecting and quantifying HAdV DNA and mRNA of the HAdV hexon gene in adenoid and palatine tonsil tissues and nasopharyngeal secretions (NPS) from patients with adenotonsillar hypertrophy or recurrent adenotonsillitis. Although this study indicates that a significant proportion (~85%) of individuals with chronic adenotonsillar diseases have persistent nonproductive HAdV infection, including those by HAdV C, B, and E, epithelial and subepithelial cells in tonsils seem to be critical for HAdV C production and shedding in NPS in some patients, since viral antigen was detected in these regions by immunohistochemistry in four patients, all of which were also positive for HAdV mRNA detection. This was a cross-sectional study that evaluated the presence of HAdV in different samples of tissues and secretions from the upper respiratory tract of children with obstructive sleep apnea (OSA) or recurrent tonsillitis, comparing the results with control patients.	./cache/cord-345044-2fez1gu0.txt	./txt/cord-345044-2fez1gu0.txt