id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350019-4nlbu54e	Robinson, Elektra K.	The how and why of lncRNA function: An innate immune perspective()	2019-09-02		.txt	text/plain	13173	715	44	Using this extensively studied biological system, we identified the first example of a TLR-stimulated lncRNA, lincRNA-Cox2, which was capable of positively and negatively regulating distinct types of innate immune genes [42] [43] [44] [45] [46] . The majority of lncRNAs studied in immunity were initially identified following RNA-sequencing to examine their expression profiles in specific cell lines or tissues during inflammatory activation. Hence future studies may opt to target TF binding sites, secondary structure and/or polyadenylation sites as a way to more finely dissect the functional portions of lncRNAs. The ease in which Cas9 can be targeted to specific genomic regions sparked the development of a modified (catalytically inactivated) version of the protein fused to the KRAB (Krüppel associated box) chromatin-silencing domain termed CRISPRi [174, 175] (Fig. 3C) . Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites	./cache/cord-350019-4nlbu54e.txt	./txt/cord-350019-4nlbu54e.txt