id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350836-1enteev7	Brisse, Morgan	Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5	2019-07-17		.txt	text/plain	16347	859	47	RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection. For the former, siRNA-mediated knock-down (110, 111) , cellular knockout (112) and inhibition by viral protein (109, (113) (114) (115) (116) conditions for TRIM25 in multiple cell types have been shown to change RIG-I cellular localization (110) and to negatively affect RIG-I K63 ubiquitination, association with MAVS and IFN signaling [when the constitutively active RIG-I CARD domain was overexpressed (109, (112) (113) (114) (115) (116) or during viral infection (109, 111, 114) ].	./cache/cord-350836-1enteev7.txt	./txt/cord-350836-1enteev7.txt