id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352807-1yhxnvoh	Guan, De-Long	Analysis of codon usage patterns in Hirudinaria manillensis reveals a preference for GC-ending codons caused by dominant selection constraints	2018-07-17		.txt	text/plain	7856	373	47	manillensis had an overall preference toward C-endings and indicated that codon usage patterns are mediated by differential expression, GC content, and biological function. In general, mutation pressure tends to shuffle A/U and G/C pairs to cause nucleotide composition bias, selection constraints lead to preferences for codons that maximise protein production efficiency in highly expressed genes, and genetic drift eliminates codon changes across generations as a result of immigration and emigration at the population level. It would be of great value to generate more reliable coding sequences for new gene discovery; furthermore, the genetic processes revealed by their codon usage patterns will further contribute to determining the effects of long-term evolution on the genetically diversified and unique physiological behaviour of medical leeches. Their codon usage patterns, which were calculated as GC12/GC3 ratios and ENC values, were compared to the average values obtained from all CDSs to measure the effects of different evolutionary states of anticoagulant-related mechanisms.	./cache/cord-352807-1yhxnvoh.txt	./txt/cord-352807-1yhxnvoh.txt