id	sid	tid	token	lemma	pos
cord-003091-uvfppirt	1	1	key	key	JJ
cord-003091-uvfppirt	1	2	:	:	:
cord-003091-uvfppirt	1	3	cord-003091-uvfppirt	cord-003091-uvfppirt	CD
cord-003091-uvfppirt	1	4	authors	author	NNS
cord-003091-uvfppirt	1	5	:	:	:
cord-003091-uvfppirt	1	6	Gornati	Gornati	NNP
cord-003091-uvfppirt	1	7	,	,	,
cord-003091-uvfppirt	1	8	Laura	Laura	NNP
cord-003091-uvfppirt	1	9	;	;	:
cord-003091-uvfppirt	1	10	Zanoni	Zanoni	NNP
cord-003091-uvfppirt	1	11	,	,	,
cord-003091-uvfppirt	1	12	Ivan	Ivan	NNP
cord-003091-uvfppirt	1	13	;	;	:
cord-003091-uvfppirt	1	14	Granucci	Granucci	NNP
cord-003091-uvfppirt	1	15	,	,	,
cord-003091-uvfppirt	1	16	Francesca	Francesca	NNP
cord-003091-uvfppirt	1	17	title	title	NN
cord-003091-uvfppirt	1	18	:	:	:
cord-003091-uvfppirt	1	19	Dendritic	Dendritic	NNP
cord-003091-uvfppirt	1	20	Cells	Cells	NNPS
cord-003091-uvfppirt	1	21	in	in	IN
cord-003091-uvfppirt	1	22	the	the	DT
cord-003091-uvfppirt	1	23	Cross	Cross	NNP
cord-003091-uvfppirt	1	24	Hair	Hair	NNP
cord-003091-uvfppirt	1	25	for	for	IN
cord-003091-uvfppirt	1	26	the	the	DT
cord-003091-uvfppirt	1	27	Generation	generation	NN
cord-003091-uvfppirt	1	28	of	of	IN
cord-003091-uvfppirt	1	29	Tailored	Tailored	NNP
cord-003091-uvfppirt	1	30	Vaccines	Vaccines	NNPS
cord-003091-uvfppirt	1	31	date	date	NN
cord-003091-uvfppirt	1	32	:	:	:
cord-003091-uvfppirt	1	33	2018	2018	CD
cord-003091-uvfppirt	1	34	-	-	HYPH
cord-003091-uvfppirt	1	35	06	06	CD
cord-003091-uvfppirt	1	36	-	-	SYM
cord-003091-uvfppirt	1	37	27	27	CD
cord-003091-uvfppirt	1	38	journal	journal	NN
cord-003091-uvfppirt	1	39	:	:	:
cord-003091-uvfppirt	2	1	Front	Front	NNP
cord-003091-uvfppirt	2	2	Immunol	Immunol	NNP
cord-003091-uvfppirt	2	3	DOI	DOI	NNP
cord-003091-uvfppirt	2	4	:	:	:
cord-003091-uvfppirt	2	5	10.3389	10.3389	CD
cord-003091-uvfppirt	2	6	/	/	SYM
cord-003091-uvfppirt	2	7	fimmu.2018.01484	fimmu.2018.01484	NN
cord-003091-uvfppirt	2	8	sha	sha	NNP
cord-003091-uvfppirt	2	9	:	:	:
cord-003091-uvfppirt	2	10	10905e5423cc57fa9bd97aba8a348a3866953874	10905e5423cc57fa9bd97aba8a348a3866953874	CD
cord-003091-uvfppirt	2	11	doc_id	doc_id	CD
cord-003091-uvfppirt	2	12	:	:	:
cord-003091-uvfppirt	2	13	3091	3091	CD
cord-003091-uvfppirt	2	14	cord_uid	cord_uid	NN
cord-003091-uvfppirt	2	15	:	:	:
cord-003091-uvfppirt	3	1	uvfppirt	uvfppirt	NNP
cord-003091-uvfppirt	4	1	Vaccines	vaccine	NNS
cord-003091-uvfppirt	4	2	represent	represent	VBP
cord-003091-uvfppirt	4	3	the	the	DT
cord-003091-uvfppirt	4	4	discovery	discovery	NN
cord-003091-uvfppirt	4	5	of	of	IN
cord-003091-uvfppirt	4	6	utmost	utmost	JJ
cord-003091-uvfppirt	4	7	importance	importance	NN
cord-003091-uvfppirt	4	8	for	for	IN
cord-003091-uvfppirt	4	9	global	global	JJ
cord-003091-uvfppirt	4	10	health	health	NN
cord-003091-uvfppirt	4	11	,	,	,
cord-003091-uvfppirt	4	12	due	due	IN
cord-003091-uvfppirt	4	13	to	to	IN
cord-003091-uvfppirt	4	14	both	both	CC
cord-003091-uvfppirt	4	15	prophylactic	prophylactic	JJ
cord-003091-uvfppirt	4	16	action	action	NN
cord-003091-uvfppirt	4	17	to	to	TO
cord-003091-uvfppirt	4	18	prevent	prevent	VB
cord-003091-uvfppirt	4	19	infections	infection	NNS
cord-003091-uvfppirt	4	20	and	and	CC
cord-003091-uvfppirt	4	21	therapeutic	therapeutic	JJ
cord-003091-uvfppirt	4	22	intervention	intervention	NN
cord-003091-uvfppirt	4	23	in	in	IN
cord-003091-uvfppirt	4	24	neoplastic	neoplastic	JJ
cord-003091-uvfppirt	4	25	diseases	disease	NNS
cord-003091-uvfppirt	4	26	.	.	.
cord-003091-uvfppirt	5	1	Despite	despite	IN
cord-003091-uvfppirt	5	2	this	this	DT
cord-003091-uvfppirt	5	3	,	,	,
cord-003091-uvfppirt	5	4	current	current	JJ
cord-003091-uvfppirt	5	5	vaccination	vaccination	NN
cord-003091-uvfppirt	5	6	strategies	strategy	NNS
cord-003091-uvfppirt	5	7	need	need	VBP
cord-003091-uvfppirt	5	8	to	to	TO
cord-003091-uvfppirt	5	9	be	be	VB
cord-003091-uvfppirt	5	10	refined	refine	VBN
cord-003091-uvfppirt	5	11	to	to	TO
cord-003091-uvfppirt	5	12	successfully	successfully	RB
cord-003091-uvfppirt	5	13	generate	generate	VB
cord-003091-uvfppirt	5	14	robust	robust	JJ
cord-003091-uvfppirt	5	15	protective	protective	JJ
cord-003091-uvfppirt	5	16	antigen	antigen	NN
cord-003091-uvfppirt	5	17	-	-	HYPH
cord-003091-uvfppirt	5	18	specific	specific	JJ
cord-003091-uvfppirt	5	19	memory	memory	NN
cord-003091-uvfppirt	5	20	immune	immune	JJ
cord-003091-uvfppirt	5	21	responses	response	NNS
cord-003091-uvfppirt	5	22	.	.	.
cord-003091-uvfppirt	6	1	To	to	TO
cord-003091-uvfppirt	6	2	address	address	VB
cord-003091-uvfppirt	6	3	this	this	DT
cord-003091-uvfppirt	6	4	issue	issue	NN
cord-003091-uvfppirt	6	5	,	,	,
cord-003091-uvfppirt	6	6	one	one	CD
cord-003091-uvfppirt	6	7	possibility	possibility	NN
cord-003091-uvfppirt	6	8	is	be	VBZ
cord-003091-uvfppirt	6	9	to	to	TO
cord-003091-uvfppirt	6	10	exploit	exploit	VB
cord-003091-uvfppirt	6	11	the	the	DT
cord-003091-uvfppirt	6	12	high	high	JJ
cord-003091-uvfppirt	6	13	efficiency	efficiency	NN
cord-003091-uvfppirt	6	14	of	of	IN
cord-003091-uvfppirt	6	15	dendritic	dendritic	JJ
cord-003091-uvfppirt	6	16	cells	cell	NNS
cord-003091-uvfppirt	6	17	(	(	-LRB-
cord-003091-uvfppirt	6	18	DCs	DCs	NNP
cord-003091-uvfppirt	6	19	)	)	-RRB-
cord-003091-uvfppirt	6	20	as	as	IN
cord-003091-uvfppirt	6	21	antigen	antigen	NN
cord-003091-uvfppirt	6	22	-	-	HYPH
cord-003091-uvfppirt	6	23	presenting	present	VBG
cord-003091-uvfppirt	6	24	cells	cell	NNS
cord-003091-uvfppirt	6	25	for	for	IN
cord-003091-uvfppirt	6	26	T	t	NN
cord-003091-uvfppirt	6	27	cell	cell	NN
cord-003091-uvfppirt	6	28	priming	priming	NN
cord-003091-uvfppirt	6	29	.	.	.
cord-003091-uvfppirt	7	1	DCs	DCs	NNP
cord-003091-uvfppirt	7	2	functional	functional	JJ
cord-003091-uvfppirt	7	3	plasticity	plasticity	NN
cord-003091-uvfppirt	7	4	allows	allow	VBZ
cord-003091-uvfppirt	7	5	shaping	shape	VBG
cord-003091-uvfppirt	7	6	the	the	DT
cord-003091-uvfppirt	7	7	outcome	outcome	NN
cord-003091-uvfppirt	7	8	of	of	IN
cord-003091-uvfppirt	7	9	immune	immune	JJ
cord-003091-uvfppirt	7	10	responses	response	NNS
cord-003091-uvfppirt	7	11	to	to	TO
cord-003091-uvfppirt	7	12	achieve	achieve	VB
cord-003091-uvfppirt	7	13	the	the	DT
cord-003091-uvfppirt	7	14	required	required	JJ
cord-003091-uvfppirt	7	15	type	type	NN
cord-003091-uvfppirt	7	16	of	of	IN
cord-003091-uvfppirt	7	17	immunity	immunity	NN
cord-003091-uvfppirt	7	18	.	.	.
cord-003091-uvfppirt	8	1	Therefore	therefore	RB
cord-003091-uvfppirt	8	2	,	,	,
cord-003091-uvfppirt	8	3	the	the	DT
cord-003091-uvfppirt	8	4	choice	choice	NN
cord-003091-uvfppirt	8	5	of	of	IN
cord-003091-uvfppirt	8	6	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	8	7	to	to	TO
cord-003091-uvfppirt	8	8	guide	guide	VB
cord-003091-uvfppirt	8	9	and	and	CC
cord-003091-uvfppirt	8	10	sustain	sustain	VB
cord-003091-uvfppirt	8	11	DCs	dcs	JJ
cord-003091-uvfppirt	8	12	maturation	maturation	NN
cord-003091-uvfppirt	8	13	,	,	,
cord-003091-uvfppirt	8	14	the	the	DT
cord-003091-uvfppirt	8	15	design	design	NN
cord-003091-uvfppirt	8	16	of	of	IN
cord-003091-uvfppirt	8	17	multifaceted	multifaceted	JJ
cord-003091-uvfppirt	8	18	vehicles	vehicle	NNS
cord-003091-uvfppirt	8	19	,	,	,
cord-003091-uvfppirt	8	20	and	and	CC
cord-003091-uvfppirt	8	21	the	the	DT
cord-003091-uvfppirt	8	22	choice	choice	NN
cord-003091-uvfppirt	8	23	of	of	IN
cord-003091-uvfppirt	8	24	surface	surface	NN
cord-003091-uvfppirt	8	25	molecules	molecule	NNS
cord-003091-uvfppirt	8	26	to	to	TO
cord-003091-uvfppirt	8	27	specifically	specifically	RB
cord-003091-uvfppirt	8	28	target	target	VB
cord-003091-uvfppirt	8	29	DCs	DCs	NNP
cord-003091-uvfppirt	8	30	represent	represent	VBP
cord-003091-uvfppirt	8	31	the	the	DT
cord-003091-uvfppirt	8	32	key	key	JJ
cord-003091-uvfppirt	8	33	issues	issue	NNS
cord-003091-uvfppirt	8	34	currently	currently	RB
cord-003091-uvfppirt	8	35	explored	explore	VBN
cord-003091-uvfppirt	8	36	in	in	IN
cord-003091-uvfppirt	8	37	both	both	DT
cord-003091-uvfppirt	8	38	preclinical	preclinical	JJ
cord-003091-uvfppirt	8	39	and	and	CC
cord-003091-uvfppirt	8	40	clinical	clinical	JJ
cord-003091-uvfppirt	8	41	settings	setting	NNS
cord-003091-uvfppirt	8	42	.	.	.
cord-003091-uvfppirt	9	1	Here	here	RB
cord-003091-uvfppirt	9	2	,	,	,
cord-003091-uvfppirt	9	3	we	-PRON-	PRP
cord-003091-uvfppirt	9	4	review	review	VBP
cord-003091-uvfppirt	9	5	advances	advance	NNS
cord-003091-uvfppirt	9	6	in	in	IN
cord-003091-uvfppirt	9	7	DCs	DCs	NNP
cord-003091-uvfppirt	9	8	-	-	HYPH
cord-003091-uvfppirt	9	9	based	base	VBN
cord-003091-uvfppirt	9	10	vaccination	vaccination	NN
cord-003091-uvfppirt	9	11	approaches	approach	NNS
cord-003091-uvfppirt	9	12	,	,	,
cord-003091-uvfppirt	9	13	which	which	WDT
cord-003091-uvfppirt	9	14	exploit	exploit	VBP
cord-003091-uvfppirt	9	15	direct	direct	JJ
cord-003091-uvfppirt	9	16	in	in	IN
cord-003091-uvfppirt	9	17	vivo	vivo	FW
cord-003091-uvfppirt	9	18	DCs	dc	NNS
cord-003091-uvfppirt	9	19	targeting	target	VBG
cord-003091-uvfppirt	9	20	and	and	CC
cord-003091-uvfppirt	9	21	activation	activation	NN
cord-003091-uvfppirt	9	22	options	option	NNS
cord-003091-uvfppirt	9	23	.	.	.
cord-003091-uvfppirt	10	1	We	-PRON-	PRP
cord-003091-uvfppirt	10	2	also	also	RB
cord-003091-uvfppirt	10	3	discuss	discuss	VBP
cord-003091-uvfppirt	10	4	the	the	DT
cord-003091-uvfppirt	10	5	recent	recent	JJ
cord-003091-uvfppirt	10	6	findings	finding	NNS
cord-003091-uvfppirt	10	7	for	for	IN
cord-003091-uvfppirt	10	8	efficient	efficient	JJ
cord-003091-uvfppirt	10	9	antitumor	antitumor	JJ
cord-003091-uvfppirt	10	10	DCs	dc	NNS
cord-003091-uvfppirt	10	11	-	-	HYPH
cord-003091-uvfppirt	10	12	based	base	VBN
cord-003091-uvfppirt	10	13	vaccinations	vaccination	NNS
cord-003091-uvfppirt	10	14	and	and	CC
cord-003091-uvfppirt	10	15	combination	combination	NN
cord-003091-uvfppirt	10	16	strategies	strategy	NNS
cord-003091-uvfppirt	10	17	to	to	TO
cord-003091-uvfppirt	10	18	reduce	reduce	VB
cord-003091-uvfppirt	10	19	the	the	DT
cord-003091-uvfppirt	10	20	immune	immune	JJ
cord-003091-uvfppirt	10	21	tolerance	tolerance	NN
cord-003091-uvfppirt	10	22	promoted	promote	VBN
cord-003091-uvfppirt	10	23	by	by	IN
cord-003091-uvfppirt	10	24	the	the	DT
cord-003091-uvfppirt	10	25	tumor	tumor	NN
cord-003091-uvfppirt	10	26	microenvironment	microenvironment	NN
cord-003091-uvfppirt	10	27	.	.	.
cord-003091-uvfppirt	11	1	iNTRODUCTiON	iNTRODUCTiON	NNP
cord-003091-uvfppirt	12	1	Vaccines	vaccine	NNS
cord-003091-uvfppirt	12	2	represent	represent	VBP
cord-003091-uvfppirt	12	3	one	one	CD
cord-003091-uvfppirt	12	4	of	of	IN
cord-003091-uvfppirt	12	5	the	the	DT
cord-003091-uvfppirt	12	6	most	most	RBS
cord-003091-uvfppirt	12	7	effective	effective	JJ
cord-003091-uvfppirt	12	8	Copernican	copernican	JJ
cord-003091-uvfppirt	12	9	revolutions	revolution	NNS
cord-003091-uvfppirt	12	10	for	for	IN
cord-003091-uvfppirt	12	11	humankind	humankind	NN
cord-003091-uvfppirt	12	12	and	and	CC
cord-003091-uvfppirt	12	13	world	world	NN
cord-003091-uvfppirt	12	14	health	health	NN
cord-003091-uvfppirt	12	15	.	.	.
cord-003091-uvfppirt	13	1	This	this	DT
cord-003091-uvfppirt	13	2	innovative	innovative	JJ
cord-003091-uvfppirt	13	3	discovery	discovery	NN
cord-003091-uvfppirt	13	4	by	by	IN
cord-003091-uvfppirt	13	5	Edward	Edward	NNP
cord-003091-uvfppirt	13	6	Jenner	Jenner	NNP
cord-003091-uvfppirt	13	7	in	in	IN
cord-003091-uvfppirt	13	8	the	the	DT
cord-003091-uvfppirt	13	9	late	late	JJ
cord-003091-uvfppirt	13	10	years	year	NNS
cord-003091-uvfppirt	13	11	of	of	IN
cord-003091-uvfppirt	13	12	the	the	DT
cord-003091-uvfppirt	13	13	XVIII	XVIII	NNP
cord-003091-uvfppirt	13	14	century	century	NN
cord-003091-uvfppirt	13	15	allowed	allow	VBN
cord-003091-uvfppirt	13	16	for	for	IN
cord-003091-uvfppirt	13	17	control	control	NN
cord-003091-uvfppirt	13	18	or	or	CC
cord-003091-uvfppirt	13	19	complete	complete	JJ
cord-003091-uvfppirt	13	20	eradication	eradication	NN
cord-003091-uvfppirt	13	21	of	of	IN
cord-003091-uvfppirt	13	22	infectious	infectious	JJ
cord-003091-uvfppirt	13	23	diseases	disease	NNS
cord-003091-uvfppirt	13	24	as	as	IN
cord-003091-uvfppirt	13	25	smallpox	smallpox	NN
cord-003091-uvfppirt	13	26	(	(	-LRB-
cord-003091-uvfppirt	13	27	1979	1979	CD
cord-003091-uvfppirt	13	28	)	)	-RRB-
cord-003091-uvfppirt	13	29	and	and	CC
cord-003091-uvfppirt	13	30	rinderpest	rinderpest	NN
cord-003091-uvfppirt	13	31	virus	virus	NN
cord-003091-uvfppirt	13	32	(	(	-LRB-
cord-003091-uvfppirt	13	33	2011	2011	CD
cord-003091-uvfppirt	13	34	)	)	-RRB-
cord-003091-uvfppirt	13	35	(	(	-LRB-
cord-003091-uvfppirt	13	36	1	1	CD
cord-003091-uvfppirt	13	37	)	)	-RRB-
cord-003091-uvfppirt	13	38	.	.	.
cord-003091-uvfppirt	14	1	This	this	DT
cord-003091-uvfppirt	14	2	immunization	immunization	NN
cord-003091-uvfppirt	14	3	strategy	strategy	NN
cord-003091-uvfppirt	14	4	posed	pose	VBD
cord-003091-uvfppirt	14	5	the	the	DT
cord-003091-uvfppirt	14	6	bases	basis	NNS
cord-003091-uvfppirt	14	7	for	for	IN
cord-003091-uvfppirt	14	8	current	current	JJ
cord-003091-uvfppirt	14	9	remarkable	remarkable	JJ
cord-003091-uvfppirt	14	10	therapeutic	therapeutic	JJ
cord-003091-uvfppirt	14	11	approaches	approach	NNS
cord-003091-uvfppirt	14	12	against	against	IN
cord-003091-uvfppirt	14	13	not	not	RB
cord-003091-uvfppirt	14	14	only	only	RB
cord-003091-uvfppirt	14	15	infections	infection	NNS
cord-003091-uvfppirt	14	16	but	but	CC
cord-003091-uvfppirt	14	17	also	also	RB
cord-003091-uvfppirt	14	18	cancer	cancer	NN
cord-003091-uvfppirt	14	19	.	.	.
cord-003091-uvfppirt	15	1	In	in	IN
cord-003091-uvfppirt	15	2	evolutionary	evolutionary	JJ
cord-003091-uvfppirt	15	3	terms	term	NNS
cord-003091-uvfppirt	15	4	,	,	,
cord-003091-uvfppirt	15	5	pathogens	pathogen	NNS
cord-003091-uvfppirt	15	6	have	have	VBP
cord-003091-uvfppirt	15	7	acquired	acquire	VBN
cord-003091-uvfppirt	15	8	the	the	DT
cord-003091-uvfppirt	15	9	capability	capability	NN
cord-003091-uvfppirt	15	10	to	to	TO
cord-003091-uvfppirt	15	11	circumvent	circumvent	VB
cord-003091-uvfppirt	15	12	the	the	DT
cord-003091-uvfppirt	15	13	immune	immune	JJ
cord-003091-uvfppirt	15	14	system	system	NN
cord-003091-uvfppirt	15	15	with	with	IN
cord-003091-uvfppirt	15	16	several	several	JJ
cord-003091-uvfppirt	15	17	evasion	evasion	NN
cord-003091-uvfppirt	15	18	mechanisms	mechanism	NNS
cord-003091-uvfppirt	15	19	,	,	,
cord-003091-uvfppirt	15	20	revised	revise	VBN
cord-003091-uvfppirt	15	21	elsewhere	elsewhere	RB
cord-003091-uvfppirt	15	22	(	(	-LRB-
cord-003091-uvfppirt	15	23	2	2	CD
cord-003091-uvfppirt	15	24	)	)	-RRB-
cord-003091-uvfppirt	15	25	,	,	,
cord-003091-uvfppirt	15	26	that	that	WDT
cord-003091-uvfppirt	15	27	prevent	prevent	VBP
cord-003091-uvfppirt	15	28	pathogen	pathogen	NN
cord-003091-uvfppirt	15	29	clearance	clearance	NN
cord-003091-uvfppirt	15	30	and	and	CC
cord-003091-uvfppirt	15	31	the	the	DT
cord-003091-uvfppirt	15	32	establishment	establishment	NN
cord-003091-uvfppirt	15	33	of	of	IN
cord-003091-uvfppirt	15	34	immune	immune	JJ
cord-003091-uvfppirt	15	35	memory	memory	NN
cord-003091-uvfppirt	15	36	.	.	.
cord-003091-uvfppirt	16	1	Vaccines	vaccine	NNS
cord-003091-uvfppirt	16	2	represent	represent	VBP
cord-003091-uvfppirt	16	3	the	the	DT
cord-003091-uvfppirt	16	4	unique	unique	JJ
cord-003091-uvfppirt	16	5	tool	tool	NN
cord-003091-uvfppirt	16	6	we	-PRON-	PRP
cord-003091-uvfppirt	16	7	have	have	VBP
cord-003091-uvfppirt	16	8	to	to	TO
cord-003091-uvfppirt	16	9	impede	impede	VB
cord-003091-uvfppirt	16	10	pathogen	pathogen	NN
cord-003091-uvfppirt	16	11	spread	spread	NN
cord-003091-uvfppirt	16	12	;	;	:
cord-003091-uvfppirt	16	13	therefore	therefore	RB
cord-003091-uvfppirt	16	14	,	,	,
cord-003091-uvfppirt	16	15	the	the	DT
cord-003091-uvfppirt	16	16	urgent	urgent	JJ
cord-003091-uvfppirt	16	17	need	need	NN
cord-003091-uvfppirt	16	18	for	for	IN
cord-003091-uvfppirt	16	19	efficient	efficient	JJ
cord-003091-uvfppirt	16	20	vaccines	vaccine	NNS
cord-003091-uvfppirt	16	21	is	be	VBZ
cord-003091-uvfppirt	16	22	as	as	RB
cord-003091-uvfppirt	16	23	relevant	relevant	JJ
cord-003091-uvfppirt	16	24	as	as	IN
cord-003091-uvfppirt	16	25	before	before	RB
cord-003091-uvfppirt	16	26	.	.	.
cord-003091-uvfppirt	17	1	Mycobacterium	Mycobacterium	NNP
cord-003091-uvfppirt	17	2	tuberculosis	tuberculosis	NN
cord-003091-uvfppirt	17	3	,	,	,
cord-003091-uvfppirt	17	4	which	which	WDT
cord-003091-uvfppirt	17	5	causes	cause	VBZ
cord-003091-uvfppirt	17	6	tuberculosis	tuberculosis	NN
cord-003091-uvfppirt	17	7	,	,	,
cord-003091-uvfppirt	17	8	is	be	VBZ
cord-003091-uvfppirt	17	9	currently	currently	RB
cord-003091-uvfppirt	17	10	one	one	CD
cord-003091-uvfppirt	17	11	of	of	IN
cord-003091-uvfppirt	17	12	the	the	DT
cord-003091-uvfppirt	17	13	most	most	RBS
cord-003091-uvfppirt	17	14	feared	fear	VBN
cord-003091-uvfppirt	17	15	infectious	infectious	JJ
cord-003091-uvfppirt	17	16	agent	agent	NN
cord-003091-uvfppirt	17	17	due	due	IN
cord-003091-uvfppirt	17	18	to	to	IN
cord-003091-uvfppirt	17	19	its	-PRON-	PRP$
cord-003091-uvfppirt	17	20	capability	capability	NN
cord-003091-uvfppirt	17	21	to	to	TO
cord-003091-uvfppirt	17	22	evade	evade	VB
cord-003091-uvfppirt	17	23	the	the	DT
cord-003091-uvfppirt	17	24	immune	immune	JJ
cord-003091-uvfppirt	17	25	system	system	NN
cord-003091-uvfppirt	17	26	,	,	,
cord-003091-uvfppirt	17	27	leading	lead	VBG
cord-003091-uvfppirt	17	28	to	to	IN
cord-003091-uvfppirt	17	29	death	death	NN
cord-003091-uvfppirt	17	30	of	of	IN
cord-003091-uvfppirt	17	31	more	more	JJR
cord-003091-uvfppirt	17	32	than	than	IN
cord-003091-uvfppirt	17	33	one	one	CD
cord-003091-uvfppirt	17	34	million	million	CD
cord-003091-uvfppirt	17	35	of	of	IN
cord-003091-uvfppirt	17	36	people	people	NNS
cord-003091-uvfppirt	17	37	per	per	IN
cord-003091-uvfppirt	17	38	year	year	NN
cord-003091-uvfppirt	17	39	.	.	.
cord-003091-uvfppirt	18	1	Unbelievably	unbelievably	RB
cord-003091-uvfppirt	18	2	,	,	,
cord-003091-uvfppirt	18	3	the	the	DT
cord-003091-uvfppirt	18	4	only	only	JJ
cord-003091-uvfppirt	18	5	licensed	licensed	JJ
cord-003091-uvfppirt	18	6	vaccine	vaccine	NN
cord-003091-uvfppirt	18	7	against	against	IN
cord-003091-uvfppirt	18	8	Mycobacterium	Mycobacterium	NNP
cord-003091-uvfppirt	18	9	tuberculosis	tuberculosis	NN
cord-003091-uvfppirt	18	10	is	be	VBZ
cord-003091-uvfppirt	18	11	bacillus	bacillus	NN
cord-003091-uvfppirt	18	12	Calmette	Calmette	NNP
cord-003091-uvfppirt	18	13	-	-	HYPH
cord-003091-uvfppirt	18	14	Guérin	Guérin	NNP
cord-003091-uvfppirt	18	15	(	(	-LRB-
cord-003091-uvfppirt	18	16	BCG	BCG	NNP
cord-003091-uvfppirt	18	17	)	)	-RRB-
cord-003091-uvfppirt	18	18	conceived	conceive	VBD
cord-003091-uvfppirt	18	19	about	about	RB
cord-003091-uvfppirt	18	20	100	100	CD
cord-003091-uvfppirt	18	21	years	year	NNS
cord-003091-uvfppirt	18	22	ago	ago	RB
cord-003091-uvfppirt	18	23	.	.	.
cord-003091-uvfppirt	19	1	Nonetheless	nonetheless	RB
cord-003091-uvfppirt	19	2	,	,	,
cord-003091-uvfppirt	19	3	BCG	BCG	NNP
cord-003091-uvfppirt	19	4	has	have	VBZ
cord-003091-uvfppirt	19	5	displayed	display	VBN
cord-003091-uvfppirt	19	6	some	some	DT
cord-003091-uvfppirt	19	7	degree	degree	NN
cord-003091-uvfppirt	19	8	of	of	IN
cord-003091-uvfppirt	19	9	inefficacy	inefficacy	NN
cord-003091-uvfppirt	19	10	in	in	IN
cord-003091-uvfppirt	19	11	humans	human	NNS
cord-003091-uvfppirt	19	12	,	,	,
cord-003091-uvfppirt	19	13	thus	thus	RB
cord-003091-uvfppirt	19	14	raising	raise	VBG
cord-003091-uvfppirt	19	15	the	the	DT
cord-003091-uvfppirt	19	16	need	need	NN
cord-003091-uvfppirt	19	17	for	for	IN
cord-003091-uvfppirt	19	18	new	new	JJ
cord-003091-uvfppirt	19	19	tailored	tailored	JJ
cord-003091-uvfppirt	19	20	vaccination	vaccination	NN
cord-003091-uvfppirt	19	21	strategies	strategy	NNS
cord-003091-uvfppirt	19	22	that	that	WDT
cord-003091-uvfppirt	19	23	are	be	VBP
cord-003091-uvfppirt	19	24	currently	currently	RB
cord-003091-uvfppirt	19	25	under	under	IN
cord-003091-uvfppirt	19	26	investigation	investigation	NN
cord-003091-uvfppirt	19	27	(	(	-LRB-
cord-003091-uvfppirt	19	28	3	3	CD
cord-003091-uvfppirt	19	29	)	)	-RRB-
cord-003091-uvfppirt	19	30	.	.	.
cord-003091-uvfppirt	20	1	Moreover	moreover	RB
cord-003091-uvfppirt	20	2	,	,	,
cord-003091-uvfppirt	20	3	every	every	DT
cord-003091-uvfppirt	20	4	year	year	NN
cord-003091-uvfppirt	20	5	,	,	,
cord-003091-uvfppirt	20	6	new	new	JJ
cord-003091-uvfppirt	20	7	cases	case	NNS
cord-003091-uvfppirt	20	8	of	of	IN
cord-003091-uvfppirt	20	9	human	human	JJ
cord-003091-uvfppirt	20	10	immunodeficiency	immunodeficiency	NN
cord-003091-uvfppirt	20	11	virus	virus	NN
cord-003091-uvfppirt	20	12	(	(	-LRB-
cord-003091-uvfppirt	20	13	HIV	HIV	NNP
cord-003091-uvfppirt	20	14	)	)	-RRB-
cord-003091-uvfppirt	20	15	infections	infection	NNS
cord-003091-uvfppirt	20	16	lead	lead	VBP
cord-003091-uvfppirt	20	17	to	to	IN
cord-003091-uvfppirt	20	18	the	the	DT
cord-003091-uvfppirt	20	19	necessity	necessity	NN
cord-003091-uvfppirt	20	20	of	of	IN
cord-003091-uvfppirt	20	21	a	a	DT
cord-003091-uvfppirt	20	22	vaccine	vaccine	NN
cord-003091-uvfppirt	20	23	to	to	TO
cord-003091-uvfppirt	20	24	control	control	VB
cord-003091-uvfppirt	20	25	and	and	CC
cord-003091-uvfppirt	20	26	prevent	prevent	VB
cord-003091-uvfppirt	20	27	the	the	DT
cord-003091-uvfppirt	20	28	spread	spread	NN
cord-003091-uvfppirt	20	29	of	of	IN
cord-003091-uvfppirt	20	30	the	the	DT
cord-003091-uvfppirt	20	31	virus	virus	NN
cord-003091-uvfppirt	20	32	.	.	.
cord-003091-uvfppirt	21	1	Up	up	IN
cord-003091-uvfppirt	21	2	to	to	IN
cord-003091-uvfppirt	21	3	now	now	RB
cord-003091-uvfppirt	21	4	,	,	,
cord-003091-uvfppirt	21	5	vaccines	vaccine	NNS
cord-003091-uvfppirt	21	6	against	against	IN
cord-003091-uvfppirt	21	7	HIV	HIV	NNP
cord-003091-uvfppirt	21	8	have	have	VBP
cord-003091-uvfppirt	21	9	not	not	RB
cord-003091-uvfppirt	21	10	passed	pass	VBN
cord-003091-uvfppirt	21	11	phase	phase	NN
cord-003091-uvfppirt	21	12	II	ii	CD
cord-003091-uvfppirt	21	13	clinical	clinical	JJ
cord-003091-uvfppirt	21	14	trials	trial	NNS
cord-003091-uvfppirt	21	15	due	due	JJ
cord-003091-uvfppirt	21	16	to	to	IN
cord-003091-uvfppirt	21	17	poor	poor	JJ
cord-003091-uvfppirt	21	18	protection	protection	NN
cord-003091-uvfppirt	21	19	conferred	confer	VBN
cord-003091-uvfppirt	21	20	,	,	,
cord-003091-uvfppirt	21	21	requiring	require	VBG
cord-003091-uvfppirt	21	22	revision	revision	NN
cord-003091-uvfppirt	21	23	of	of	IN
cord-003091-uvfppirt	21	24	delivered	deliver	VBN
cord-003091-uvfppirt	21	25	antigens	antigen	NNS
cord-003091-uvfppirt	21	26	(	(	-LRB-
cord-003091-uvfppirt	21	27	ags	ags	NNP
cord-003091-uvfppirt	21	28	)	)	-RRB-
cord-003091-uvfppirt	21	29	and	and	CC
cord-003091-uvfppirt	21	30	strategy	strategy	NN
cord-003091-uvfppirt	21	31	to	to	TO
cord-003091-uvfppirt	21	32	improve	improve	VB
cord-003091-uvfppirt	21	33	T	T	NNP
cord-003091-uvfppirt	21	34	cell	cell	NN
cord-003091-uvfppirt	21	35	response	response	NN
cord-003091-uvfppirt	21	36	(	(	-LRB-
cord-003091-uvfppirt	21	37	4	4	CD
cord-003091-uvfppirt	21	38	)	)	-RRB-
cord-003091-uvfppirt	21	39	.	.	.
cord-003091-uvfppirt	22	1	Moreover	moreover	RB
cord-003091-uvfppirt	22	2	,	,	,
cord-003091-uvfppirt	22	3	the	the	DT
cord-003091-uvfppirt	22	4	recent	recent	JJ
cord-003091-uvfppirt	22	5	outbreaks	outbreak	NNS
cord-003091-uvfppirt	22	6	of	of	IN
cord-003091-uvfppirt	22	7	Ebola	Ebola	NNP
cord-003091-uvfppirt	22	8	virus	virus	NN
cord-003091-uvfppirt	22	9	and	and	CC
cord-003091-uvfppirt	22	10	Zika	Zika	NNP
cord-003091-uvfppirt	22	11	virus	virus	NN
cord-003091-uvfppirt	22	12	infections	infection	NNS
cord-003091-uvfppirt	22	13	clearly	clearly	RB
cord-003091-uvfppirt	22	14	demonstrate	demonstrate	VBP
cord-003091-uvfppirt	22	15	that	that	IN
cord-003091-uvfppirt	22	16	still	still	RB
cord-003091-uvfppirt	22	17	nowadays	nowadays	RB
cord-003091-uvfppirt	22	18	more	more	JJR
cord-003091-uvfppirt	22	19	than	than	IN
cord-003091-uvfppirt	22	20	few	few	JJ
cord-003091-uvfppirt	22	21	infectious	infectious	JJ
cord-003091-uvfppirt	22	22	diseases	disease	NNS
cord-003091-uvfppirt	22	23	need	need	VBP
cord-003091-uvfppirt	22	24	to	to	TO
cord-003091-uvfppirt	22	25	be	be	VB
cord-003091-uvfppirt	22	26	overwhelmed	overwhelm	VBN
cord-003091-uvfppirt	22	27	,	,	,
cord-003091-uvfppirt	22	28	as	as	IN
cord-003091-uvfppirt	22	29	reported	report	VBN
cord-003091-uvfppirt	22	30	by	by	IN
cord-003091-uvfppirt	22	31	the	the	DT
cord-003091-uvfppirt	22	32	World	World	NNP
cord-003091-uvfppirt	22	33	Health	Health	NNP
cord-003091-uvfppirt	22	34	Organization	Organization	NNP
cord-003091-uvfppirt	22	35	.	.	.
cord-003091-uvfppirt	23	1	On	on	IN
cord-003091-uvfppirt	23	2	the	the	DT
cord-003091-uvfppirt	23	3	other	other	JJ
cord-003091-uvfppirt	23	4	hand	hand	NN
cord-003091-uvfppirt	23	5	,	,	,
cord-003091-uvfppirt	23	6	vaccines	vaccine	NNS
cord-003091-uvfppirt	23	7	represent	represent	VBP
cord-003091-uvfppirt	23	8	also	also	RB
cord-003091-uvfppirt	23	9	a	a	DT
cord-003091-uvfppirt	23	10	therapeutic	therapeutic	JJ
cord-003091-uvfppirt	23	11	tool	tool	NN
cord-003091-uvfppirt	23	12	against	against	IN
cord-003091-uvfppirt	23	13	cancer	cancer	NN
cord-003091-uvfppirt	23	14	.	.	.
cord-003091-uvfppirt	24	1	One	one	CD
cord-003091-uvfppirt	24	2	of	of	IN
cord-003091-uvfppirt	24	3	the	the	DT
cord-003091-uvfppirt	24	4	hallmarks	hallmark	NNS
cord-003091-uvfppirt	24	5	of	of	IN
cord-003091-uvfppirt	24	6	cancer	cancer	NN
cord-003091-uvfppirt	24	7	is	be	VBZ
cord-003091-uvfppirt	24	8	the	the	DT
cord-003091-uvfppirt	24	9	capability	capability	NN
cord-003091-uvfppirt	24	10	of	of	IN
cord-003091-uvfppirt	24	11	tumor	tumor	NN
cord-003091-uvfppirt	24	12	cells	cell	NNS
cord-003091-uvfppirt	24	13	to	to	TO
cord-003091-uvfppirt	24	14	evade	evade	VB
cord-003091-uvfppirt	24	15	immune	immune	NN
cord-003091-uvfppirt	24	16	-	-	HYPH
cord-003091-uvfppirt	24	17	mediated	mediate	VBN
cord-003091-uvfppirt	24	18	destruction	destruction	NN
cord-003091-uvfppirt	24	19	(	(	-LRB-
cord-003091-uvfppirt	24	20	5	5	CD
cord-003091-uvfppirt	24	21	)	)	-RRB-
cord-003091-uvfppirt	24	22	by	by	IN
cord-003091-uvfppirt	24	23	promoting	promote	VBG
cord-003091-uvfppirt	24	24	a	a	DT
cord-003091-uvfppirt	24	25	tolerant	tolerant	JJ
cord-003091-uvfppirt	24	26	milieu	milieu	NN
cord-003091-uvfppirt	24	27	.	.	.
cord-003091-uvfppirt	25	1	Therefore	therefore	RB
cord-003091-uvfppirt	25	2	,	,	,
cord-003091-uvfppirt	25	3	the	the	DT
cord-003091-uvfppirt	25	4	immune	immune	JJ
cord-003091-uvfppirt	25	5	system	system	NN
cord-003091-uvfppirt	25	6	has	have	VBZ
cord-003091-uvfppirt	25	7	to	to	TO
cord-003091-uvfppirt	25	8	be	be	VB
cord-003091-uvfppirt	25	9	pushed	push	VBN
cord-003091-uvfppirt	25	10	to	to	TO
cord-003091-uvfppirt	25	11	respond	respond	VB
cord-003091-uvfppirt	25	12	specifically	specifically	RB
cord-003091-uvfppirt	25	13	and	and	CC
cord-003091-uvfppirt	25	14	robustly	robustly	RB
cord-003091-uvfppirt	25	15	against	against	IN
cord-003091-uvfppirt	25	16	tumors	tumor	NNS
cord-003091-uvfppirt	25	17	cells	cell	NNS
cord-003091-uvfppirt	25	18	.	.	.
cord-003091-uvfppirt	26	1	To	to	TO
cord-003091-uvfppirt	26	2	address	address	VB
cord-003091-uvfppirt	26	3	this	this	DT
cord-003091-uvfppirt	26	4	purpose	purpose	NN
cord-003091-uvfppirt	26	5	,	,	,
cord-003091-uvfppirt	26	6	it	-PRON-	PRP
cord-003091-uvfppirt	26	7	is	be	VBZ
cord-003091-uvfppirt	26	8	becoming	become	VBG
cord-003091-uvfppirt	26	9	more	more	RBR
cord-003091-uvfppirt	26	10	and	and	CC
cord-003091-uvfppirt	26	11	more	more	RBR
cord-003091-uvfppirt	26	12	evident	evident	JJ
cord-003091-uvfppirt	26	13	that	that	IN
cord-003091-uvfppirt	26	14	dendritic	dendritic	JJ
cord-003091-uvfppirt	26	15	cells	cell	NNS
cord-003091-uvfppirt	26	16	(	(	-LRB-
cord-003091-uvfppirt	26	17	DCs	DCs	NNP
cord-003091-uvfppirt	26	18	)	)	-RRB-
cord-003091-uvfppirt	26	19	stand	stand	VB
cord-003091-uvfppirt	26	20	out	out	RP
cord-003091-uvfppirt	26	21	as	as	IN
cord-003091-uvfppirt	26	22	a	a	DT
cord-003091-uvfppirt	26	23	potent	potent	JJ
cord-003091-uvfppirt	26	24	tool	tool	NN
cord-003091-uvfppirt	26	25	in	in	IN
cord-003091-uvfppirt	26	26	our	-PRON-	PRP$
cord-003091-uvfppirt	26	27	hands	hand	NNS
cord-003091-uvfppirt	26	28	,	,	,
cord-003091-uvfppirt	26	29	being	be	VBG
cord-003091-uvfppirt	26	30	the	the	DT
cord-003091-uvfppirt	26	31	mediators	mediator	NNS
cord-003091-uvfppirt	26	32	of	of	IN
cord-003091-uvfppirt	26	33	cellular	cellular	JJ
cord-003091-uvfppirt	26	34	and	and	CC
cord-003091-uvfppirt	26	35	humoral	humoral	JJ
cord-003091-uvfppirt	26	36	responses	response	NNS
cord-003091-uvfppirt	26	37	(	(	-LRB-
cord-003091-uvfppirt	26	38	6	6	CD
cord-003091-uvfppirt	26	39	)	)	-RRB-
cord-003091-uvfppirt	26	40	.	.	.
cord-003091-uvfppirt	27	1	DCs	dc	NNS
cord-003091-uvfppirt	27	2	have	have	VBP
cord-003091-uvfppirt	27	3	been	be	VBN
cord-003091-uvfppirt	27	4	discovered	discover	VBN
cord-003091-uvfppirt	27	5	in	in	IN
cord-003091-uvfppirt	27	6	1973	1973	CD
cord-003091-uvfppirt	27	7	by	by	IN
cord-003091-uvfppirt	27	8	R.	R.	NNP
cord-003091-uvfppirt	27	9	Steinman	Steinman	NNP
cord-003091-uvfppirt	27	10	and	and	CC
cord-003091-uvfppirt	27	11	Z.	Z.	NNP
cord-003091-uvfppirt	27	12	Cohn	Cohn	NNP
cord-003091-uvfppirt	27	13	that	that	WDT
cord-003091-uvfppirt	27	14	divided	divide	VBD
cord-003091-uvfppirt	27	15	phagocytic	phagocytic	JJ
cord-003091-uvfppirt	27	16	cells	cell	NNS
cord-003091-uvfppirt	27	17	(	(	-LRB-
cord-003091-uvfppirt	27	18	discovered	discover	VBN
cord-003091-uvfppirt	27	19	by	by	IN
cord-003091-uvfppirt	27	20	E.	E.	NNP
cord-003091-uvfppirt	27	21	Metchnikoff	Metchnikoff	NNP
cord-003091-uvfppirt	27	22	in	in	IN
cord-003091-uvfppirt	27	23	1887	1887	CD
cord-003091-uvfppirt	27	24	)	)	-RRB-
cord-003091-uvfppirt	27	25	in	in	IN
cord-003091-uvfppirt	27	26	macrophages	macrophage	NNS
cord-003091-uvfppirt	27	27	and	and	CC
cord-003091-uvfppirt	27	28	DCs	dc	NNS
cord-003091-uvfppirt	27	29	on	on	IN
cord-003091-uvfppirt	27	30	the	the	DT
cord-003091-uvfppirt	27	31	basis	basis	NN
cord-003091-uvfppirt	27	32	of	of	IN
cord-003091-uvfppirt	27	33	different	different	JJ
cord-003091-uvfppirt	27	34	effector	effector	NN
cord-003091-uvfppirt	27	35	functions	function	NNS
cord-003091-uvfppirt	27	36	:	:	:
cord-003091-uvfppirt	27	37	microbial	microbial	JJ
cord-003091-uvfppirt	27	38	scavenging	scavenging	NN
cord-003091-uvfppirt	27	39	activities	activity	NNS
cord-003091-uvfppirt	27	40	for	for	IN
cord-003091-uvfppirt	27	41	macrophages	macrophage	NNS
cord-003091-uvfppirt	27	42	and	and	CC
cord-003091-uvfppirt	27	43	antigen	antigen	NN
cord-003091-uvfppirt	27	44	-	-	HYPH
cord-003091-uvfppirt	27	45	presenting	present	VBG
cord-003091-uvfppirt	27	46	function	function	NN
cord-003091-uvfppirt	27	47	for	for	IN
cord-003091-uvfppirt	27	48	DCs	DCs	NNP
cord-003091-uvfppirt	27	49	(	(	-LRB-
cord-003091-uvfppirt	27	50	7	7	CD
cord-003091-uvfppirt	27	51	,	,	,
cord-003091-uvfppirt	27	52	8)	8)	NN
cord-003091-uvfppirt	27	53	.	.	.
cord-003091-uvfppirt	28	1	Since	since	IN
cord-003091-uvfppirt	28	2	then	then	RB
cord-003091-uvfppirt	28	3	,	,	,
cord-003091-uvfppirt	28	4	DCs	dc	NNS
cord-003091-uvfppirt	28	5	have	have	VBP
cord-003091-uvfppirt	28	6	emerged	emerge	VBN
cord-003091-uvfppirt	28	7	as	as	IN
cord-003091-uvfppirt	28	8	the	the	DT
cord-003091-uvfppirt	28	9	most	most	RBS
cord-003091-uvfppirt	28	10	potent	potent	JJ
cord-003091-uvfppirt	28	11	antigen	antigen	NN
cord-003091-uvfppirt	28	12	-	-	HYPH
cord-003091-uvfppirt	28	13	presenting	present	VBG
cord-003091-uvfppirt	28	14	cells	cell	NNS
cord-003091-uvfppirt	28	15	capable	capable	JJ
cord-003091-uvfppirt	28	16	of	of	IN
cord-003091-uvfppirt	28	17	shaping	shape	VBG
cord-003091-uvfppirt	28	18	adaptive	adaptive	JJ
cord-003091-uvfppirt	28	19	responses	response	NNS
cord-003091-uvfppirt	28	20	both	both	DT
cord-003091-uvfppirt	28	21	during	during	IN
cord-003091-uvfppirt	28	22	infections	infection	NNS
cord-003091-uvfppirt	28	23	and	and	CC
cord-003091-uvfppirt	28	24	cancer	cancer	NN
cord-003091-uvfppirt	28	25	.	.	.
cord-003091-uvfppirt	29	1	Moreover	moreover	RB
cord-003091-uvfppirt	29	2	,	,	,
cord-003091-uvfppirt	29	3	the	the	DT
cord-003091-uvfppirt	29	4	broad	broad	JJ
cord-003091-uvfppirt	29	5	spectrum	spectrum	NN
cord-003091-uvfppirt	29	6	of	of	IN
cord-003091-uvfppirt	29	7	DCs	DCs	NNP
cord-003091-uvfppirt	29	8	activation	activation	NN
cord-003091-uvfppirt	29	9	makes	make	VBZ
cord-003091-uvfppirt	29	10	them	-PRON-	PRP
cord-003091-uvfppirt	29	11	suitable	suitable	JJ
cord-003091-uvfppirt	29	12	for	for	IN
cord-003091-uvfppirt	29	13	fine	fine	JJ
cord-003091-uvfppirt	29	14	shifting	shifting	NN
cord-003091-uvfppirt	29	15	of	of	IN
cord-003091-uvfppirt	29	16	the	the	DT
cord-003091-uvfppirt	29	17	type	type	NN
cord-003091-uvfppirt	29	18	of	of	IN
cord-003091-uvfppirt	29	19	response	response	NN
cord-003091-uvfppirt	29	20	the	the	DT
cord-003091-uvfppirt	29	21	context	context	NN
cord-003091-uvfppirt	29	22	needs	need	VBZ
cord-003091-uvfppirt	29	23	.	.	.
cord-003091-uvfppirt	30	1	Taking	take	VBG
cord-003091-uvfppirt	30	2	advantage	advantage	NN
cord-003091-uvfppirt	30	3	of	of	IN
cord-003091-uvfppirt	30	4	new	new	JJ
cord-003091-uvfppirt	30	5	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	30	6	,	,	,
cord-003091-uvfppirt	30	7	innovative	innovative	JJ
cord-003091-uvfppirt	30	8	ags	ag	NNS
cord-003091-uvfppirt	30	9	-	-	HYPH
cord-003091-uvfppirt	30	10	delivery	delivery	NN
cord-003091-uvfppirt	30	11	carriers	carrier	NNS
cord-003091-uvfppirt	30	12	and	and	CC
cord-003091-uvfppirt	30	13	targeting	target	VBG
cord-003091-uvfppirt	30	14	strategies	strategy	NNS
cord-003091-uvfppirt	30	15	,	,	,
cord-003091-uvfppirt	30	16	it	-PRON-	PRP
cord-003091-uvfppirt	30	17	is	be	VBZ
cord-003091-uvfppirt	30	18	now	now	RB
cord-003091-uvfppirt	30	19	feasible	feasible	JJ
cord-003091-uvfppirt	30	20	to	to	TO
cord-003091-uvfppirt	30	21	optimize	optimize	VB
cord-003091-uvfppirt	30	22	the	the	DT
cord-003091-uvfppirt	30	23	activation	activation	NN
cord-003091-uvfppirt	30	24	and	and	CC
cord-003091-uvfppirt	30	25	ag	ag	NNP
cord-003091-uvfppirt	30	26	presentation	presentation	NN
cord-003091-uvfppirt	30	27	processes	process	NNS
cord-003091-uvfppirt	30	28	by	by	IN
cord-003091-uvfppirt	30	29	the	the	DT
cord-003091-uvfppirt	30	30	specific	specific	JJ
cord-003091-uvfppirt	30	31	DCs	dc	NNS
cord-003091-uvfppirt	30	32	subset	subset	NNP
cord-003091-uvfppirt	30	33	that	that	WDT
cord-003091-uvfppirt	30	34	is	be	VBZ
cord-003091-uvfppirt	30	35	the	the	DT
cord-003091-uvfppirt	30	36	most	most	RBS
cord-003091-uvfppirt	30	37	effective	effective	JJ
cord-003091-uvfppirt	30	38	in	in	IN
cord-003091-uvfppirt	30	39	the	the	DT
cord-003091-uvfppirt	30	40	initiation	initiation	NN
cord-003091-uvfppirt	30	41	of	of	IN
cord-003091-uvfppirt	30	42	the	the	DT
cord-003091-uvfppirt	30	43	adaptive	adaptive	JJ
cord-003091-uvfppirt	30	44	response	response	NN
cord-003091-uvfppirt	30	45	needed	need	VBN
cord-003091-uvfppirt	30	46	in	in	IN
cord-003091-uvfppirt	30	47	a	a	DT
cord-003091-uvfppirt	30	48	given	give	VBN
cord-003091-uvfppirt	30	49	context	context	NN
cord-003091-uvfppirt	30	50	.	.	.
cord-003091-uvfppirt	31	1	Here	here	RB
cord-003091-uvfppirt	31	2	,	,	,
cord-003091-uvfppirt	31	3	we	-PRON-	PRP
cord-003091-uvfppirt	31	4	discuss	discuss	VBP
cord-003091-uvfppirt	31	5	the	the	DT
cord-003091-uvfppirt	31	6	diverse	diverse	JJ
cord-003091-uvfppirt	31	7	phenotypical	phenotypical	JJ
cord-003091-uvfppirt	31	8	and	and	CC
cord-003091-uvfppirt	31	9	functional	functional	JJ
cord-003091-uvfppirt	31	10	properties	property	NNS
cord-003091-uvfppirt	31	11	of	of	IN
cord-003091-uvfppirt	31	12	DCs	DCs	NNP
cord-003091-uvfppirt	31	13	subtypes	subtype	NNS
cord-003091-uvfppirt	31	14	that	that	WDT
cord-003091-uvfppirt	31	15	are	be	VBP
cord-003091-uvfppirt	31	16	exploited	exploit	VBN
cord-003091-uvfppirt	31	17	by	by	IN
cord-003091-uvfppirt	31	18	recently	recently	RB
cord-003091-uvfppirt	31	19	developed	develop	VBN
cord-003091-uvfppirt	31	20	vaccine	vaccine	NN
cord-003091-uvfppirt	31	21	approaches	approach	NNS
cord-003091-uvfppirt	31	22	,	,	,
cord-003091-uvfppirt	31	23	dealing	deal	VBG
cord-003091-uvfppirt	31	24	with	with	IN
cord-003091-uvfppirt	31	25	advances	advance	NNS
cord-003091-uvfppirt	31	26	in	in	IN
cord-003091-uvfppirt	31	27	the	the	DT
cord-003091-uvfppirt	31	28	use	use	NN
cord-003091-uvfppirt	31	29	of	of	IN
cord-003091-uvfppirt	31	30	ags	ag	NNS
cord-003091-uvfppirt	31	31	,	,	,
cord-003091-uvfppirt	31	32	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	31	33	,	,	,
cord-003091-uvfppirt	31	34	carriers	carrier	NNS
cord-003091-uvfppirt	31	35	and	and	CC
cord-003091-uvfppirt	31	36	DCs	dc	NNS
cord-003091-uvfppirt	31	37	-	-	HYPH
cord-003091-uvfppirt	31	38	expressed	express	VBN
cord-003091-uvfppirt	31	39	molecules	molecule	NNS
cord-003091-uvfppirt	31	40	,	,	,
cord-003091-uvfppirt	31	41	object	object	NN
cord-003091-uvfppirt	31	42	of	of	IN
cord-003091-uvfppirt	31	43	targeting	target	VBG
cord-003091-uvfppirt	31	44	.	.	.
cord-003091-uvfppirt	32	1	Dendritic	dendritic	JJ
cord-003091-uvfppirt	32	2	cells	cell	NNS
cord-003091-uvfppirt	32	3	are	be	VBP
cord-003091-uvfppirt	32	4	the	the	DT
cord-003091-uvfppirt	32	5	primary	primary	JJ
cord-003091-uvfppirt	32	6	professional	professional	JJ
cord-003091-uvfppirt	32	7	antigen	antigen	NN
cord-003091-uvfppirt	32	8	-	-	HYPH
cord-003091-uvfppirt	32	9	presenting	present	VBG
cord-003091-uvfppirt	32	10	cells	cell	NNS
cord-003091-uvfppirt	32	11	(	(	-LRB-
cord-003091-uvfppirt	32	12	APCs	apc	NNS
cord-003091-uvfppirt	32	13	)	)	-RRB-
cord-003091-uvfppirt	32	14	that	that	WDT
cord-003091-uvfppirt	32	15	reside	reside	VBP
cord-003091-uvfppirt	32	16	in	in	IN
cord-003091-uvfppirt	32	17	both	both	DT
cord-003091-uvfppirt	32	18	lymphoid	lymphoid	JJ
cord-003091-uvfppirt	32	19	and	and	CC
cord-003091-uvfppirt	32	20	non	non	JJ
cord-003091-uvfppirt	32	21	-	-	JJ
cord-003091-uvfppirt	32	22	lymphoid	lymphoid	JJ
cord-003091-uvfppirt	32	23	organs	organ	NNS
cord-003091-uvfppirt	32	24	(	(	-LRB-
cord-003091-uvfppirt	32	25	9	9	CD
cord-003091-uvfppirt	32	26	)	)	-RRB-
cord-003091-uvfppirt	32	27	(	(	-LRB-
cord-003091-uvfppirt	32	28	10	10	CD
cord-003091-uvfppirt	32	29	)	)	-RRB-
cord-003091-uvfppirt	32	30	(	(	-LRB-
cord-003091-uvfppirt	32	31	11	11	CD
cord-003091-uvfppirt	32	32	)	)	-RRB-
cord-003091-uvfppirt	32	33	.	.	.
cord-003091-uvfppirt	33	1	DCs	DCs	NNP
cord-003091-uvfppirt	33	2	encompass	encompass	VBP
cord-003091-uvfppirt	33	3	several	several	JJ
cord-003091-uvfppirt	33	4	heterogeneous	heterogeneous	JJ
cord-003091-uvfppirt	33	5	subsets	subset	NNS
cord-003091-uvfppirt	33	6	whose	whose	WP$
cord-003091-uvfppirt	33	7	subdivision	subdivision	NN
cord-003091-uvfppirt	33	8	relies	rely	VBZ
cord-003091-uvfppirt	33	9	on	on	IN
cord-003091-uvfppirt	33	10	ontogeny	ontogeny	NN
cord-003091-uvfppirt	33	11	,	,	,
cord-003091-uvfppirt	33	12	expression	expression	NN
cord-003091-uvfppirt	33	13	of	of	IN
cord-003091-uvfppirt	33	14	surface	surface	NN
cord-003091-uvfppirt	33	15	-	-	HYPH
cord-003091-uvfppirt	33	16	receptors	receptor	NNS
cord-003091-uvfppirt	33	17	,	,	,
cord-003091-uvfppirt	33	18	and	and	CC
cord-003091-uvfppirt	33	19	transcription	transcription	NN
cord-003091-uvfppirt	33	20	factors	factor	NNS
cord-003091-uvfppirt	33	21	(	(	-LRB-
cord-003091-uvfppirt	33	22	12	12	CD
cord-003091-uvfppirt	33	23	)	)	-RRB-
cord-003091-uvfppirt	33	24	(	(	-LRB-
cord-003091-uvfppirt	33	25	13	13	CD
cord-003091-uvfppirt	33	26	)	)	-RRB-
cord-003091-uvfppirt	33	27	(	(	-LRB-
cord-003091-uvfppirt	33	28	14	14	CD
cord-003091-uvfppirt	33	29	)	)	-RRB-
cord-003091-uvfppirt	33	30	.	.	.
cord-003091-uvfppirt	34	1	Much	much	JJ
cord-003091-uvfppirt	34	2	effort	effort	NN
cord-003091-uvfppirt	34	3	has	have	VBZ
cord-003091-uvfppirt	34	4	been	be	VBN
cord-003091-uvfppirt	34	5	done	do	VBN
cord-003091-uvfppirt	34	6	in	in	IN
cord-003091-uvfppirt	34	7	the	the	DT
cord-003091-uvfppirt	34	8	identification	identification	NN
cord-003091-uvfppirt	34	9	and	and	CC
cord-003091-uvfppirt	34	10	characterization	characterization	NN
cord-003091-uvfppirt	34	11	of	of	IN
cord-003091-uvfppirt	34	12	tissue	tissue	NN
cord-003091-uvfppirt	34	13	-	-	HYPH
cord-003091-uvfppirt	34	14	specific	specific	JJ
cord-003091-uvfppirt	34	15	DC	DC	NNP
cord-003091-uvfppirt	34	16	subsets	subset	NNS
cord-003091-uvfppirt	34	17	to	to	TO
cord-003091-uvfppirt	34	18	unravel	unravel	VB
cord-003091-uvfppirt	34	19	the	the	DT
cord-003091-uvfppirt	34	20	correlation	correlation	NN
cord-003091-uvfppirt	34	21	between	between	IN
cord-003091-uvfppirt	34	22	phenotype	phenotype	NN
cord-003091-uvfppirt	34	23	,	,	,
cord-003091-uvfppirt	34	24	localization	localization	NN
cord-003091-uvfppirt	34	25	,	,	,
cord-003091-uvfppirt	34	26	and	and	CC
cord-003091-uvfppirt	34	27	functional	functional	JJ
cord-003091-uvfppirt	34	28	properties	property	NNS
cord-003091-uvfppirt	34	29	,	,	,
cord-003091-uvfppirt	34	30	both	both	CC
cord-003091-uvfppirt	34	31	in	in	IN
cord-003091-uvfppirt	34	32	health	health	NN
cord-003091-uvfppirt	34	33	and	and	CC
cord-003091-uvfppirt	34	34	disease	disease	NN
cord-003091-uvfppirt	34	35	.	.	.
cord-003091-uvfppirt	35	1	Initially	initially	RB
cord-003091-uvfppirt	35	2	,	,	,
cord-003091-uvfppirt	35	3	DCs	DCs	NNP
cord-003091-uvfppirt	35	4	have	have	VBP
cord-003091-uvfppirt	35	5	been	be	VBN
cord-003091-uvfppirt	35	6	classified	classify	VBN
cord-003091-uvfppirt	35	7	into	into	IN
cord-003091-uvfppirt	35	8	conventional	conventional	JJ
cord-003091-uvfppirt	35	9	DCs	dc	NNS
cord-003091-uvfppirt	35	10	(	(	-LRB-
cord-003091-uvfppirt	35	11	cDCs	cDCs	NNP
cord-003091-uvfppirt	35	12	)	)	-RRB-
cord-003091-uvfppirt	35	13	and	and	CC
cord-003091-uvfppirt	35	14	plasmacytoid	plasmacytoid	NNP
cord-003091-uvfppirt	35	15	DCs	DCs	NNP
cord-003091-uvfppirt	35	16	(	(	-LRB-
cord-003091-uvfppirt	35	17	pDCs	pDCs	NNP
cord-003091-uvfppirt	35	18	)	)	-RRB-
cord-003091-uvfppirt	35	19	.	.	.
cord-003091-uvfppirt	36	1	Briefly	briefly	RB
cord-003091-uvfppirt	36	2	,	,	,
cord-003091-uvfppirt	36	3	cDCs	cdcs	JJ
cord-003091-uvfppirt	36	4	prime	prime	JJ
cord-003091-uvfppirt	36	5	naïve	naïve	JJ
cord-003091-uvfppirt	36	6	T	T	NNP
cord-003091-uvfppirt	36	7	cells	cell	NNS
cord-003091-uvfppirt	36	8	and	and	CC
cord-003091-uvfppirt	36	9	orchestrate	orchestrate	VB
cord-003091-uvfppirt	36	10	ag	ag	JJ
cord-003091-uvfppirt	36	11	-	-	HYPH
cord-003091-uvfppirt	36	12	specific	specific	JJ
cord-003091-uvfppirt	36	13	adaptive	adaptive	JJ
cord-003091-uvfppirt	36	14	responses	response	NNS
cord-003091-uvfppirt	36	15	,	,	,
cord-003091-uvfppirt	36	16	while	while	IN
cord-003091-uvfppirt	36	17	pDCs	pdcs	PRP
cord-003091-uvfppirt	36	18	intervene	intervene	VB
cord-003091-uvfppirt	36	19	during	during	IN
cord-003091-uvfppirt	36	20	viral	viral	JJ
cord-003091-uvfppirt	36	21	infections	infection	NNS
cord-003091-uvfppirt	36	22	producing	produce	VBG
cord-003091-uvfppirt	36	23	type	type	NN
cord-003091-uvfppirt	36	24	I	-PRON-	PRP
cord-003091-uvfppirt	36	25	interferons	interferon	NNS
cord-003091-uvfppirt	36	26	(	(	-LRB-
cord-003091-uvfppirt	36	27	IFNs	IFNs	NNP
cord-003091-uvfppirt	36	28	)	)	-RRB-
cord-003091-uvfppirt	36	29	.	.	.
cord-003091-uvfppirt	37	1	Advanced	advanced	JJ
cord-003091-uvfppirt	37	2	approaches	approach	NNS
cord-003091-uvfppirt	37	3	have	have	VBP
cord-003091-uvfppirt	37	4	extremely	extremely	RB
cord-003091-uvfppirt	37	5	pushed	push	VBN
cord-003091-uvfppirt	37	6	our	-PRON-	PRP$
cord-003091-uvfppirt	37	7	understanding	understanding	NN
cord-003091-uvfppirt	37	8	of	of	IN
cord-003091-uvfppirt	37	9	DC	DC	NNP
cord-003091-uvfppirt	37	10	biology	biology	NN
cord-003091-uvfppirt	37	11	,	,	,
cord-003091-uvfppirt	37	12	resulting	result	VBG
cord-003091-uvfppirt	37	13	in	in	IN
cord-003091-uvfppirt	37	14	a	a	DT
cord-003091-uvfppirt	37	15	recent	recent	JJ
cord-003091-uvfppirt	37	16	readapted	readapted	JJ
cord-003091-uvfppirt	37	17	taxonomy	taxonomy	NN
cord-003091-uvfppirt	37	18	(	(	-LRB-
cord-003091-uvfppirt	37	19	12	12	CD
cord-003091-uvfppirt	37	20	,	,	,
cord-003091-uvfppirt	37	21	15	15	CD
cord-003091-uvfppirt	37	22	,	,	,
cord-003091-uvfppirt	37	23	16	16	CD
cord-003091-uvfppirt	37	24	)	)	-RRB-
cord-003091-uvfppirt	37	25	.	.	.
cord-003091-uvfppirt	38	1	Indeed	indeed	RB
cord-003091-uvfppirt	38	2	,	,	,
cord-003091-uvfppirt	38	3	Villani	Villani	NNP
cord-003091-uvfppirt	38	4	and	and	CC
cord-003091-uvfppirt	38	5	colleagues	colleague	NNS
cord-003091-uvfppirt	38	6	identify	identify	VBP
cord-003091-uvfppirt	38	7	six	six	CD
cord-003091-uvfppirt	38	8	subsets	subset	NNS
cord-003091-uvfppirt	38	9	of	of	IN
cord-003091-uvfppirt	38	10	DCs	dc	NNS
cord-003091-uvfppirt	38	11	and	and	CC
cord-003091-uvfppirt	38	12	monocytes	monocyte	NNS
cord-003091-uvfppirt	38	13	in	in	IN
cord-003091-uvfppirt	38	14	human	human	JJ
cord-003091-uvfppirt	38	15	(	(	-LRB-
cord-003091-uvfppirt	38	16	Figure	figure	NN
cord-003091-uvfppirt	38	17	1	1	CD
cord-003091-uvfppirt	38	18	):	):	NN
cord-003091-uvfppirt	38	19	DC1	DC1	NNP
cord-003091-uvfppirt	38	20	(	(	-LRB-
cord-003091-uvfppirt	38	21	CLEC9A	CLEC9A	NNP
cord-003091-uvfppirt	38	22	+	+	.
cord-003091-uvfppirt	39	1	CD141	CD141	NNP
cord-003091-uvfppirt	39	2	+	+	CC
cord-003091-uvfppirt	39	3	DCs	DCs	NNP
cord-003091-uvfppirt	39	4	)	)	-RRB-
cord-003091-uvfppirt	39	5	,	,	,
cord-003091-uvfppirt	39	6	DC2	DC2	NNP
cord-003091-uvfppirt	39	7	and	and	CC
cord-003091-uvfppirt	39	8	DC3	DC3	NNP
cord-003091-uvfppirt	39	9	(	(	-LRB-
cord-003091-uvfppirt	39	10	CD1c	CD1c	NNP
cord-003091-uvfppirt	39	11	+	+	SYM
cord-003091-uvfppirt	39	12	DCs	DCs	NNP
cord-003091-uvfppirt	39	13	)	)	-RRB-
cord-003091-uvfppirt	39	14	,	,	,
cord-003091-uvfppirt	39	15	DC4	DC4	NNP
cord-003091-uvfppirt	39	16	(	(	-LRB-
cord-003091-uvfppirt	39	17	FCGR3A	FCGR3A	NNP
cord-003091-uvfppirt	39	18	/	/	SYM
cord-003091-uvfppirt	39	19	CD16	CD16	NNP
cord-003091-uvfppirt	39	20	+	+	CC
cord-003091-uvfppirt	39	21	DCs	DCs	NNP
cord-003091-uvfppirt	39	22	)	)	-RRB-
cord-003091-uvfppirt	39	23	,	,	,
cord-003091-uvfppirt	39	24	DC5	DC5	NNP
cord-003091-uvfppirt	39	25	(	(	-LRB-
cord-003091-uvfppirt	39	26	AXL	AXL	NNP
cord-003091-uvfppirt	39	27	+	+	CC
cord-003091-uvfppirt	39	28	SIGLEC6	SIGLEC6	NNPS
cord-003091-uvfppirt	39	29	+	+	CC
cord-003091-uvfppirt	39	30	DCs	DCs	NNP
cord-003091-uvfppirt	39	31	)	)	-RRB-
cord-003091-uvfppirt	39	32	and	and	CC
cord-003091-uvfppirt	39	33	DC6	DC6	NNP
cord-003091-uvfppirt	39	34	(	(	-LRB-
cord-003091-uvfppirt	39	35	pDCs	pDCs	NNP
cord-003091-uvfppirt	39	36	)	)	-RRB-
cord-003091-uvfppirt	39	37	.	.	.
cord-003091-uvfppirt	40	1	DC1	DC1	NNP
cord-003091-uvfppirt	40	2	represent	represent	VBP
cord-003091-uvfppirt	40	3	the	the	DT
cord-003091-uvfppirt	40	4	cross	cross	NN
cord-003091-uvfppirt	40	5	-	-	JJ
cord-003091-uvfppirt	40	6	presenting	presenting	JJ
cord-003091-uvfppirt	40	7	CD141	CD141	''
cord-003091-uvfppirt	41	1	+	+	CC
cord-003091-uvfppirt	41	2	/BDCA3	/BDCA3	.
cord-003091-uvfppirt	41	3	+	+	CC
cord-003091-uvfppirt	41	4	DCs	dc	NNS
cord-003091-uvfppirt	41	5	while	while	IN
cord-003091-uvfppirt	41	6	D2	D2	NNP
cord-003091-uvfppirt	41	7	and	and	CC
cord-003091-uvfppirt	41	8	D3	D3	NNP
cord-003091-uvfppirt	41	9	correspond	correspond	VBP
cord-003091-uvfppirt	41	10	to	to	TO
cord-003091-uvfppirt	41	11	cDCs	cdcs	VB
cord-003091-uvfppirt	41	12	displaying	display	VBG
cord-003091-uvfppirt	41	13	antigen	antigen	NN
cord-003091-uvfppirt	41	14	uptake	uptake	NN
cord-003091-uvfppirt	41	15	and	and	CC
cord-003091-uvfppirt	41	16	processing	processing	NN
cord-003091-uvfppirt	41	17	capabilities	capability	NNS
cord-003091-uvfppirt	41	18	.	.	.
cord-003091-uvfppirt	42	1	DC4	DC4	NNP
cord-003091-uvfppirt	42	2	seem	seem	VBP
cord-003091-uvfppirt	42	3	to	to	TO
cord-003091-uvfppirt	42	4	be	be	VB
cord-003091-uvfppirt	42	5	more	more	RBR
cord-003091-uvfppirt	42	6	prone	prone	JJ
cord-003091-uvfppirt	42	7	to	to	TO
cord-003091-uvfppirt	42	8	respond	respond	VB
cord-003091-uvfppirt	42	9	to	to	IN
cord-003091-uvfppirt	42	10	viruses	virus	NNS
cord-003091-uvfppirt	42	11	and	and	CC
cord-003091-uvfppirt	42	12	are	be	VBP
cord-003091-uvfppirt	42	13	phenotypically	phenotypically	RB
cord-003091-uvfppirt	42	14	close	close	JJ
cord-003091-uvfppirt	42	15	to	to	IN
cord-003091-uvfppirt	42	16	monocytes	monocyte	NNS
cord-003091-uvfppirt	42	17	.	.	.
cord-003091-uvfppirt	43	1	DC5	DC5	NNP
cord-003091-uvfppirt	43	2	represent	represent	VBP
cord-003091-uvfppirt	43	3	a	a	DT
cord-003091-uvfppirt	43	4	newly	newly	RB
cord-003091-uvfppirt	43	5	defined	define	VBN
cord-003091-uvfppirt	43	6	subset	subset	VBN
cord-003091-uvfppirt	43	7	that	that	IN
cord-003091-uvfppirt	43	8	share	share	NN
cord-003091-uvfppirt	43	9	features	feature	NNS
cord-003091-uvfppirt	43	10	with	with	IN
cord-003091-uvfppirt	43	11	both	both	DT
cord-003091-uvfppirt	43	12	pDCs	pdcs	XX
cord-003091-uvfppirt	44	1	and	and	CC
cord-003091-uvfppirt	44	2	cDCs	cdc	NNS
cord-003091-uvfppirt	44	3	,	,	,
cord-003091-uvfppirt	44	4	even	even	RB
cord-003091-uvfppirt	44	5	though	though	IN
cord-003091-uvfppirt	44	6	they	-PRON-	PRP
cord-003091-uvfppirt	44	7	appear	appear	VBP
cord-003091-uvfppirt	44	8	to	to	TO
cord-003091-uvfppirt	44	9	be	be	VB
cord-003091-uvfppirt	44	10	functionally	functionally	RB
cord-003091-uvfppirt	44	11	different	different	JJ
cord-003091-uvfppirt	44	12	from	from	IN
cord-003091-uvfppirt	44	13	pDCs	pDCs	NNP
cord-003091-uvfppirt	44	14	and	and	CC
cord-003091-uvfppirt	44	15	more	more	RBR
cord-003091-uvfppirt	44	16	similar	similar	JJ
cord-003091-uvfppirt	44	17	to	to	TO
cord-003091-uvfppirt	44	18	cDCs	cdcs	VB
cord-003091-uvfppirt	44	19	.	.	.
cord-003091-uvfppirt	45	1	Indeed	indeed	RB
cord-003091-uvfppirt	45	2	,	,	,
cord-003091-uvfppirt	45	3	DC5	DC5	NNP
cord-003091-uvfppirt	45	4	localize	localize	VBP
cord-003091-uvfppirt	45	5	in	in	IN
cord-003091-uvfppirt	45	6	T	T	NNP
cord-003091-uvfppirt	45	7	cell	cell	NN
cord-003091-uvfppirt	45	8	zone	zone	NN
cord-003091-uvfppirt	45	9	of	of	IN
cord-003091-uvfppirt	45	10	tonsils	tonsil	NNS
cord-003091-uvfppirt	45	11	,	,	,
cord-003091-uvfppirt	45	12	probably	probably	RB
cord-003091-uvfppirt	45	13	promoting	promote	VBG
cord-003091-uvfppirt	45	14	fast	fast	JJ
cord-003091-uvfppirt	45	15	adaptive	adaptive	JJ
cord-003091-uvfppirt	45	16	immunity	immunity	NN
cord-003091-uvfppirt	45	17	.	.	.
cord-003091-uvfppirt	46	1	Due	due	IN
cord-003091-uvfppirt	46	2	to	to	IN
cord-003091-uvfppirt	46	3	this	this	DT
cord-003091-uvfppirt	46	4	fine	fine	JJ
cord-003091-uvfppirt	46	5	clustering	clustering	NN
cord-003091-uvfppirt	46	6	,	,	,
cord-003091-uvfppirt	46	7	DC6	DC6	NNP
cord-003091-uvfppirt	46	8	correspond	correspond	VBP
cord-003091-uvfppirt	46	9	to	to	IN
cord-003091-uvfppirt	46	10	a	a	DT
cord-003091-uvfppirt	46	11	more	more	RBR
cord-003091-uvfppirt	46	12	pure	pure	JJ
cord-003091-uvfppirt	46	13	pDCs	pdcs	NN
cord-003091-uvfppirt	46	14	population	population	NN
cord-003091-uvfppirt	46	15	(	(	-LRB-
cord-003091-uvfppirt	46	16	12	12	CD
cord-003091-uvfppirt	46	17	)	)	-RRB-
cord-003091-uvfppirt	46	18	.	.	.
cord-003091-uvfppirt	47	1	This	this	DT
cord-003091-uvfppirt	47	2	precise	precise	JJ
cord-003091-uvfppirt	47	3	classification	classification	NN
cord-003091-uvfppirt	47	4	opens	open	VBZ
cord-003091-uvfppirt	47	5	the	the	DT
cord-003091-uvfppirt	47	6	way	way	NN
cord-003091-uvfppirt	47	7	for	for	IN
cord-003091-uvfppirt	47	8	a	a	DT
cord-003091-uvfppirt	47	9	more	more	RBR
cord-003091-uvfppirt	47	10	accurate	accurate	JJ
cord-003091-uvfppirt	47	11	view	view	NN
cord-003091-uvfppirt	47	12	of	of	IN
cord-003091-uvfppirt	47	13	DCs	DCs	NNP
cord-003091-uvfppirt	47	14	role	role	NN
cord-003091-uvfppirt	47	15	in	in	IN
cord-003091-uvfppirt	47	16	pathologies	pathology	NNS
cord-003091-uvfppirt	47	17	and	and	CC
cord-003091-uvfppirt	47	18	provides	provide	VBZ
cord-003091-uvfppirt	47	19	cues	cue	NNS
cord-003091-uvfppirt	47	20	for	for	IN
cord-003091-uvfppirt	47	21	more	more	RBR
cord-003091-uvfppirt	47	22	specific	specific	JJ
cord-003091-uvfppirt	47	23	targeting	targeting	NN
cord-003091-uvfppirt	47	24	in	in	IN
cord-003091-uvfppirt	47	25	immunotherapies	immunotherapy	NNS
cord-003091-uvfppirt	47	26	.	.	.
cord-003091-uvfppirt	48	1	Indeed	indeed	RB
cord-003091-uvfppirt	48	2	,	,	,
cord-003091-uvfppirt	48	3	it	-PRON-	PRP
cord-003091-uvfppirt	48	4	is	be	VBZ
cord-003091-uvfppirt	48	5	reasonable	reasonable	JJ
cord-003091-uvfppirt	48	6	to	to	TO
cord-003091-uvfppirt	48	7	assume	assume	VB
cord-003091-uvfppirt	48	8	that	that	IN
cord-003091-uvfppirt	48	9	this	this	DT
cord-003091-uvfppirt	48	10	extreme	extreme	JJ
cord-003091-uvfppirt	48	11	phenotypical	phenotypical	JJ
cord-003091-uvfppirt	48	12	diversity	diversity	NN
cord-003091-uvfppirt	48	13	correlates	correlate	VBZ
cord-003091-uvfppirt	48	14	with	with	IN
cord-003091-uvfppirt	48	15	different	different	JJ
cord-003091-uvfppirt	48	16	intrinsic	intrinsic	JJ
cord-003091-uvfppirt	48	17	functional	functional	JJ
cord-003091-uvfppirt	48	18	properties	property	NNS
cord-003091-uvfppirt	48	19	of	of	IN
cord-003091-uvfppirt	48	20	DCs	DCs	NNP
cord-003091-uvfppirt	48	21	,	,	,
cord-003091-uvfppirt	48	22	as	as	IN
cord-003091-uvfppirt	48	23	emerged	emerge	VBD
cord-003091-uvfppirt	48	24	in	in	IN
cord-003091-uvfppirt	48	25	Villani	Villani	NNP
cord-003091-uvfppirt	48	26	's	's	POS
cord-003091-uvfppirt	48	27	work	work	NN
cord-003091-uvfppirt	48	28	(	(	-LRB-
cord-003091-uvfppirt	48	29	12	12	CD
cord-003091-uvfppirt	48	30	,	,	,
cord-003091-uvfppirt	48	31	17	17	CD
cord-003091-uvfppirt	48	32	,	,	,
cord-003091-uvfppirt	48	33	18	18	CD
cord-003091-uvfppirt	48	34	)	)	-RRB-
cord-003091-uvfppirt	48	35	.	.	.
cord-003091-uvfppirt	49	1	In	in	IN
cord-003091-uvfppirt	49	2	addition	addition	NN
cord-003091-uvfppirt	49	3	,	,	,
cord-003091-uvfppirt	49	4	environmental	environmental	JJ
cord-003091-uvfppirt	49	5	cues	cue	NNS
cord-003091-uvfppirt	49	6	dictate	dictate	VBP
cord-003091-uvfppirt	49	7	DC	DC	NNP
cord-003091-uvfppirt	49	8	activation	activation	NN
cord-003091-uvfppirt	49	9	and	and	CC
cord-003091-uvfppirt	49	10	drive	drive	VB
cord-003091-uvfppirt	49	11	specific	specific	JJ
cord-003091-uvfppirt	49	12	T	t	NN
cord-003091-uvfppirt	49	13	cell	cell	NN
cord-003091-uvfppirt	49	14	responses	response	NNS
cord-003091-uvfppirt	49	15	(	(	-LRB-
cord-003091-uvfppirt	49	16	19	19	CD
cord-003091-uvfppirt	49	17	,	,	,
cord-003091-uvfppirt	49	18	20	20	CD
cord-003091-uvfppirt	49	19	)	)	-RRB-
cord-003091-uvfppirt	49	20	.	.	.
cord-003091-uvfppirt	50	1	Indeed	indeed	RB
cord-003091-uvfppirt	50	2	,	,	,
cord-003091-uvfppirt	50	3	DCs	DCs	NNP
cord-003091-uvfppirt	50	4	display	display	VBP
cord-003091-uvfppirt	50	5	a	a	DT
cord-003091-uvfppirt	50	6	plethora	plethora	NN
cord-003091-uvfppirt	50	7	of	of	IN
cord-003091-uvfppirt	50	8	pattern	pattern	NN
cord-003091-uvfppirt	50	9	recognition	recognition	NN
cord-003091-uvfppirt	50	10	receptors	receptor	NNS
cord-003091-uvfppirt	50	11	(	(	-LRB-
cord-003091-uvfppirt	50	12	PRR	PRR	NNP
cord-003091-uvfppirt	50	13	)	)	-RRB-
cord-003091-uvfppirt	50	14	that	that	WDT
cord-003091-uvfppirt	50	15	are	be	VBP
cord-003091-uvfppirt	50	16	specifically	specifically	RB
cord-003091-uvfppirt	50	17	bound	bind	VBN
cord-003091-uvfppirt	50	18	by	by	IN
cord-003091-uvfppirt	50	19	microbe	microbe	NN
cord-003091-uvfppirt	50	20	-	-	HYPH
cord-003091-uvfppirt	50	21	or	or	CC
cord-003091-uvfppirt	50	22	damage	damage	NN
cord-003091-uvfppirt	50	23	-	-	HYPH
cord-003091-uvfppirt	50	24	associated	associate	VBN
cord-003091-uvfppirt	50	25	molecular	molecular	JJ
cord-003091-uvfppirt	50	26	pattern	pattern	NN
cord-003091-uvfppirt	50	27	(	(	-LRB-
cord-003091-uvfppirt	50	28	PAMP	PAMP	NNP
cord-003091-uvfppirt	50	29	and	and	CC
cord-003091-uvfppirt	50	30	DAMP	damp	VB
cord-003091-uvfppirt	50	31	,	,	,
cord-003091-uvfppirt	50	32	respectively	respectively	RB
cord-003091-uvfppirt	50	33	)	)	-RRB-
cord-003091-uvfppirt	50	34	(	(	-LRB-
cord-003091-uvfppirt	50	35	21	21	CD
cord-003091-uvfppirt	50	36	)	)	-RRB-
cord-003091-uvfppirt	50	37	.	.	.
cord-003091-uvfppirt	51	1	Upon	upon	IN
cord-003091-uvfppirt	51	2	receptors	receptor	NNS
cord-003091-uvfppirt	51	3	engagement	engagement	NN
cord-003091-uvfppirt	51	4	in	in	IN
cord-003091-uvfppirt	51	5	peripheral	peripheral	JJ
cord-003091-uvfppirt	51	6	tissues	tissue	NNS
cord-003091-uvfppirt	51	7	,	,	,
cord-003091-uvfppirt	51	8	the	the	DT
cord-003091-uvfppirt	51	9	transduction	transduction	NN
cord-003091-uvfppirt	51	10	signals	signal	NNS
cord-003091-uvfppirt	51	11	lead	lead	VBP
cord-003091-uvfppirt	51	12	to	to	IN
cord-003091-uvfppirt	51	13	DC	DC	NNP
cord-003091-uvfppirt	51	14	maturation	maturation	NN
cord-003091-uvfppirt	51	15	with	with	IN
cord-003091-uvfppirt	51	16	the	the	DT
cord-003091-uvfppirt	51	17	upregulation	upregulation	NN
cord-003091-uvfppirt	51	18	of	of	IN
cord-003091-uvfppirt	51	19	co	co	JJ
cord-003091-uvfppirt	51	20	-	-	JJ
cord-003091-uvfppirt	51	21	stimulatory	stimulatory	JJ
cord-003091-uvfppirt	51	22	molecules	molecule	NNS
cord-003091-uvfppirt	51	23	(	(	-LRB-
cord-003091-uvfppirt	51	24	referred	refer	VBN
cord-003091-uvfppirt	51	25	to	to	IN
cord-003091-uvfppirt	51	26	as	as	IN
cord-003091-uvfppirt	51	27	"	"	``
cord-003091-uvfppirt	51	28	signal	signal	NN
cord-003091-uvfppirt	51	29	2	2	CD
cord-003091-uvfppirt	51	30	"	"	''
cord-003091-uvfppirt	51	31	)	)	-RRB-
cord-003091-uvfppirt	51	32	and	and	CC
cord-003091-uvfppirt	51	33	the	the	DT
cord-003091-uvfppirt	51	34	pivotal	pivotal	JJ
cord-003091-uvfppirt	51	35	chemokine	chemokine	NN
cord-003091-uvfppirt	51	36	receptor	receptor	NN
cord-003091-uvfppirt	51	37	CCR7	CCR7	NNP
cord-003091-uvfppirt	51	38	that	that	WDT
cord-003091-uvfppirt	51	39	allows	allow	VBZ
cord-003091-uvfppirt	51	40	DCs	DCs	NNP
cord-003091-uvfppirt	51	41	migration	migration	NN
cord-003091-uvfppirt	51	42	through	through	IN
cord-003091-uvfppirt	51	43	afferent	afferent	JJ
cord-003091-uvfppirt	51	44	lymphatic	lymphatic	JJ
cord-003091-uvfppirt	51	45	vessels	vessel	NNS
cord-003091-uvfppirt	51	46	to	to	IN
cord-003091-uvfppirt	51	47	the	the	DT
cord-003091-uvfppirt	51	48	draining	drain	VBG
cord-003091-uvfppirt	51	49	lymph	lymph	NN
cord-003091-uvfppirt	51	50	node	node	NN
cord-003091-uvfppirt	51	51	(	(	-LRB-
cord-003091-uvfppirt	51	52	LN	ln	NN
cord-003091-uvfppirt	51	53	)	)	-RRB-
cord-003091-uvfppirt	51	54	(	(	-LRB-
cord-003091-uvfppirt	51	55	22	22	CD
cord-003091-uvfppirt	51	56	)	)	-RRB-
cord-003091-uvfppirt	51	57	(	(	-LRB-
cord-003091-uvfppirt	51	58	23	23	CD
cord-003091-uvfppirt	51	59	)	)	-RRB-
cord-003091-uvfppirt	51	60	(	(	-LRB-
cord-003091-uvfppirt	51	61	24	24	CD
cord-003091-uvfppirt	51	62	)	)	-RRB-
cord-003091-uvfppirt	51	63	.	.	.
cord-003091-uvfppirt	52	1	In	in	IN
cord-003091-uvfppirt	52	2	parallel	parallel	NN
cord-003091-uvfppirt	52	3	,	,	,
cord-003091-uvfppirt	52	4	DCs	DCs	NNP
cord-003091-uvfppirt	52	5	mediate	mediate	VBP
cord-003091-uvfppirt	52	6	ag	ag	NNP
cord-003091-uvfppirt	52	7	proteolysis	proteolysis	NN
cord-003091-uvfppirt	52	8	to	to	TO
cord-003091-uvfppirt	52	9	present	present	VB
cord-003091-uvfppirt	52	10	intracellular	intracellular	JJ
cord-003091-uvfppirt	52	11	peptides	peptide	NNS
cord-003091-uvfppirt	52	12	on	on	IN
cord-003091-uvfppirt	52	13	major	major	JJ
cord-003091-uvfppirt	52	14	histocompatibility	histocompatibility	NN
cord-003091-uvfppirt	52	15	complex	complex	NN
cord-003091-uvfppirt	52	16	(	(	-LRB-
cord-003091-uvfppirt	52	17	MHC	MHC	NNP
cord-003091-uvfppirt	52	18	)	)	-RRB-
cord-003091-uvfppirt	52	19	class	class	NN
cord-003091-uvfppirt	52	20	I	-PRON-	PRP
cord-003091-uvfppirt	52	21	to	to	IN
cord-003091-uvfppirt	52	22	CD8	CD8	NNP
cord-003091-uvfppirt	52	23	+	+	CC
cord-003091-uvfppirt	52	24	T	T	NNP
cord-003091-uvfppirt	52	25	cells	cell	NNS
cord-003091-uvfppirt	52	26	and	and	CC
cord-003091-uvfppirt	52	27	exogenous	exogenous	JJ
cord-003091-uvfppirt	52	28	peptides	peptide	NNS
cord-003091-uvfppirt	52	29	on	on	IN
cord-003091-uvfppirt	52	30	MHC	MHC	NNP
cord-003091-uvfppirt	52	31	II	II	NNP
cord-003091-uvfppirt	52	32	to	to	IN
cord-003091-uvfppirt	52	33	CD4	CD4	NNP
cord-003091-uvfppirt	52	34	+	+	CC
cord-003091-uvfppirt	52	35	T	t	NN
cord-003091-uvfppirt	52	36	cells	cell	NNS
cord-003091-uvfppirt	52	37	(	(	-LRB-
cord-003091-uvfppirt	52	38	referred	refer	VBN
cord-003091-uvfppirt	52	39	as	as	IN
cord-003091-uvfppirt	52	40	"	"	``
cord-003091-uvfppirt	52	41	signal	signal	NN
cord-003091-uvfppirt	52	42	1	1	CD
cord-003091-uvfppirt	52	43	"	"	''
cord-003091-uvfppirt	52	44	)	)	-RRB-
cord-003091-uvfppirt	52	45	.	.	.
cord-003091-uvfppirt	53	1	DCs	DCs	NNP
cord-003091-uvfppirt	53	2	can	can	MD
cord-003091-uvfppirt	53	3	present	present	VB
cord-003091-uvfppirt	53	4	exogenous	exogenous	JJ
cord-003091-uvfppirt	53	5	ags	ag	NNS
cord-003091-uvfppirt	53	6	on	on	IN
cord-003091-uvfppirt	53	7	MHC	MHC	NNP
cord-003091-uvfppirt	53	8	class	class	NN
cord-003091-uvfppirt	54	1	I	-PRON-	PRP
cord-003091-uvfppirt	54	2	through	through	IN
cord-003091-uvfppirt	54	3	the	the	DT
cord-003091-uvfppirt	54	4	so	so	RB
cord-003091-uvfppirt	54	5	-	-	HYPH
cord-003091-uvfppirt	54	6	called	call	VBN
cord-003091-uvfppirt	54	7	cross	cross	NN
cord-003091-uvfppirt	54	8	-	-	NN
cord-003091-uvfppirt	54	9	presentation	presentation	NN
cord-003091-uvfppirt	54	10	,	,	,
cord-003091-uvfppirt	54	11	allowing	allow	VBG
cord-003091-uvfppirt	54	12	them	-PRON-	PRP
cord-003091-uvfppirt	54	13	to	to	TO
cord-003091-uvfppirt	54	14	induce	induce	VB
cord-003091-uvfppirt	54	15	CD8	CD8	NNP
cord-003091-uvfppirt	54	16	+	+	CC
cord-003091-uvfppirt	54	17	cytotoxic	cytotoxic	JJ
cord-003091-uvfppirt	54	18	T	t	NN
cord-003091-uvfppirt	54	19	lymphocytes	lymphocyte	NNS
cord-003091-uvfppirt	54	20	(	(	-LRB-
cord-003091-uvfppirt	54	21	CTLs	CTLs	NNP
cord-003091-uvfppirt	54	22	)	)	-RRB-
cord-003091-uvfppirt	54	23	against	against	IN
cord-003091-uvfppirt	54	24	viruses	virus	NNS
cord-003091-uvfppirt	54	25	and	and	CC
cord-003091-uvfppirt	54	26	tumor	tumor	NN
cord-003091-uvfppirt	54	27	cells	cell	NNS
cord-003091-uvfppirt	54	28	.	.	.
cord-003091-uvfppirt	55	1	Indeed	indeed	RB
cord-003091-uvfppirt	55	2	,	,	,
cord-003091-uvfppirt	55	3	once	once	RB
cord-003091-uvfppirt	55	4	in	in	IN
cord-003091-uvfppirt	55	5	the	the	DT
cord-003091-uvfppirt	55	6	LN	ln	NN
cord-003091-uvfppirt	55	7	,	,	,
cord-003091-uvfppirt	55	8	mature	mature	JJ
cord-003091-uvfppirt	55	9	DCs	DCs	NNP
cord-003091-uvfppirt	55	10	encounter	encounter	NN
cord-003091-uvfppirt	55	11	cognate	cognate	JJ
cord-003091-uvfppirt	55	12	naïve	naïve	JJ
cord-003091-uvfppirt	55	13	T	T	NNP
cord-003091-uvfppirt	55	14	cells	cell	NNS
cord-003091-uvfppirt	55	15	and	and	CC
cord-003091-uvfppirt	55	16	initiate	initiate	VB
cord-003091-uvfppirt	55	17	adaptive	adaptive	JJ
cord-003091-uvfppirt	55	18	responses	response	NNS
cord-003091-uvfppirt	55	19	(	(	-LRB-
cord-003091-uvfppirt	55	20	25	25	CD
cord-003091-uvfppirt	55	21	)	)	-RRB-
cord-003091-uvfppirt	55	22	.	.	.
cord-003091-uvfppirt	56	1	In	in	IN
cord-003091-uvfppirt	56	2	the	the	DT
cord-003091-uvfppirt	56	3	absence	absence	NN
cord-003091-uvfppirt	56	4	of	of	IN
cord-003091-uvfppirt	56	5	maturation	maturation	NN
cord-003091-uvfppirt	56	6	,	,	,
cord-003091-uvfppirt	56	7	as	as	IN
cord-003091-uvfppirt	56	8	in	in	IN
cord-003091-uvfppirt	56	9	steady	steady	JJ
cord-003091-uvfppirt	56	10	-	-	HYPH
cord-003091-uvfppirt	56	11	state	state	NN
cord-003091-uvfppirt	56	12	conditions	condition	NNS
cord-003091-uvfppirt	56	13	,	,	,
cord-003091-uvfppirt	56	14	the	the	DT
cord-003091-uvfppirt	56	15	ag	ag	NNP
cord-003091-uvfppirt	56	16	presentation	presentation	NN
cord-003091-uvfppirt	56	17	and	and	CC
cord-003091-uvfppirt	56	18	consequent	consequent	JJ
cord-003091-uvfppirt	56	19	migration	migration	NN
cord-003091-uvfppirt	56	20	to	to	IN
cord-003091-uvfppirt	56	21	LN	LN	NNP
cord-003091-uvfppirt	56	22	promote	promote	VB
cord-003091-uvfppirt	56	23	peripheral	peripheral	JJ
cord-003091-uvfppirt	56	24	tolerance	tolerance	NN
cord-003091-uvfppirt	56	25	via	via	IN
cord-003091-uvfppirt	56	26	T	t	NN
cord-003091-uvfppirt	56	27	cell	cell	NN
cord-003091-uvfppirt	56	28	anergy	anergy	NN
cord-003091-uvfppirt	56	29	or	or	CC
cord-003091-uvfppirt	56	30	regulatory	regulatory	JJ
cord-003091-uvfppirt	56	31	T	T	NNP
cord-003091-uvfppirt	56	32	cell	cell	NN
cord-003091-uvfppirt	56	33	formation	formation	NN
cord-003091-uvfppirt	56	34	(	(	-LRB-
cord-003091-uvfppirt	56	35	26	26	CD
cord-003091-uvfppirt	56	36	)	)	-RRB-
cord-003091-uvfppirt	56	37	(	(	-LRB-
cord-003091-uvfppirt	56	38	27	27	CD
cord-003091-uvfppirt	56	39	)	)	-RRB-
cord-003091-uvfppirt	56	40	(	(	-LRB-
cord-003091-uvfppirt	56	41	28	28	CD
cord-003091-uvfppirt	56	42	)	)	-RRB-
cord-003091-uvfppirt	56	43	.	.	.
cord-003091-uvfppirt	57	1	Depending	depend	VBG
cord-003091-uvfppirt	57	2	on	on	IN
cord-003091-uvfppirt	57	3	the	the	DT
cord-003091-uvfppirt	57	4	receptors	receptor	NNS
cord-003091-uvfppirt	57	5	engaged	engage	VBN
cord-003091-uvfppirt	57	6	,	,	,
cord-003091-uvfppirt	57	7	DCs	DCs	NNP
cord-003091-uvfppirt	57	8	display	display	VBP
cord-003091-uvfppirt	57	9	different	different	JJ
cord-003091-uvfppirt	57	10	maturation	maturation	NN
cord-003091-uvfppirt	57	11	states	state	NNS
cord-003091-uvfppirt	57	12	and	and	CC
cord-003091-uvfppirt	57	13	produce	produce	VB
cord-003091-uvfppirt	57	14	different	different	JJ
cord-003091-uvfppirt	57	15	inflammatory	inflammatory	JJ
cord-003091-uvfppirt	57	16	mediators	mediator	NNS
cord-003091-uvfppirt	57	17	(	(	-LRB-
cord-003091-uvfppirt	57	18	often	often	RB
cord-003091-uvfppirt	57	19	referred	refer	VBN
cord-003091-uvfppirt	57	20	to	to	IN
cord-003091-uvfppirt	57	21	as	as	IN
cord-003091-uvfppirt	57	22	"	"	``
cord-003091-uvfppirt	57	23	signal	signal	NN
cord-003091-uvfppirt	57	24	3	3	CD
cord-003091-uvfppirt	57	25	"	"	''
cord-003091-uvfppirt	57	26	)	)	-RRB-
cord-003091-uvfppirt	57	27	that	that	DT
cord-003091-uvfppirt	57	28	impact	impact	NN
cord-003091-uvfppirt	57	29	on	on	IN
cord-003091-uvfppirt	57	30	the	the	DT
cord-003091-uvfppirt	57	31	following	follow	VBG
cord-003091-uvfppirt	57	32	cellular	cellular	JJ
cord-003091-uvfppirt	57	33	and	and	CC
cord-003091-uvfppirt	57	34	humoral	humoral	JJ
cord-003091-uvfppirt	57	35	responses	response	NNS
cord-003091-uvfppirt	57	36	.	.	.
cord-003091-uvfppirt	58	1	The	the	DT
cord-003091-uvfppirt	58	2	three	three	CD
cord-003091-uvfppirt	58	3	signals	signal	NNS
cord-003091-uvfppirt	58	4	released	release	VBN
cord-003091-uvfppirt	58	5	by	by	IN
cord-003091-uvfppirt	58	6	DCs	DCs	NNP
cord-003091-uvfppirt	58	7	drive	drive	NNP
cord-003091-uvfppirt	58	8	T	T	NNP
cord-003091-uvfppirt	58	9	helper	helper	NN
cord-003091-uvfppirt	58	10	(	(	-LRB-
cord-003091-uvfppirt	58	11	Th	Th	NNP
cord-003091-uvfppirt	58	12	)	)	-RRB-
cord-003091-uvfppirt	58	13	cell	cell	NN
cord-003091-uvfppirt	58	14	differentiation	differentiation	NN
cord-003091-uvfppirt	58	15	.	.	.
cord-003091-uvfppirt	59	1	Briefly	briefly	RB
cord-003091-uvfppirt	59	2	,	,	,
cord-003091-uvfppirt	59	3	DCs	DCs	NNP
cord-003091-uvfppirt	59	4	educate	educate	VBP
cord-003091-uvfppirt	59	5	CD4	CD4	NNP
cord-003091-uvfppirt	59	6	+	+	CC
cord-003091-uvfppirt	59	7	T	t	NN
cord-003091-uvfppirt	59	8	cells	cell	NNS
cord-003091-uvfppirt	59	9	against	against	IN
cord-003091-uvfppirt	59	10	intracellular	intracellular	JJ
cord-003091-uvfppirt	59	11	bacteria	bacteria	NNS
cord-003091-uvfppirt	59	12	by	by	IN
cord-003091-uvfppirt	59	13	promoting	promote	VBG
cord-003091-uvfppirt	59	14	their	-PRON-	PRP$
cord-003091-uvfppirt	59	15	polarization	polarization	NN
cord-003091-uvfppirt	59	16	into	into	IN
cord-003091-uvfppirt	59	17	IFN	IFN	NNP
cord-003091-uvfppirt	59	18	-	-	HYPH
cord-003091-uvfppirt	59	19	γ	γ	NNP
cord-003091-uvfppirt	59	20	-	-	HYPH
cord-003091-uvfppirt	59	21	producing	produce	VBG
cord-003091-uvfppirt	59	22	Th	Th	NNP
cord-003091-uvfppirt	59	23	type	type	NN
cord-003091-uvfppirt	59	24	1	1	CD
cord-003091-uvfppirt	59	25	(	(	-LRB-
cord-003091-uvfppirt	59	26	Th1	Th1	NNP
cord-003091-uvfppirt	59	27	)	)	-RRB-
cord-003091-uvfppirt	59	28	cells	cell	NNS
cord-003091-uvfppirt	59	29	.	.	.
cord-003091-uvfppirt	60	1	Upon	upon	IN
cord-003091-uvfppirt	60	2	infection	infection	NN
cord-003091-uvfppirt	60	3	by	by	IN
cord-003091-uvfppirt	60	4	multicellular	multicellular	JJ
cord-003091-uvfppirt	60	5	parasites	parasite	NNS
cord-003091-uvfppirt	60	6	,	,	,
cord-003091-uvfppirt	60	7	DCs	DCs	NNP
cord-003091-uvfppirt	60	8	,	,	,
cord-003091-uvfppirt	60	9	with	with	IN
cord-003091-uvfppirt	60	10	the	the	DT
cord-003091-uvfppirt	60	11	help	help	NN
cord-003091-uvfppirt	60	12	of	of	IN
cord-003091-uvfppirt	60	13	basophils	basophil	NNS
cord-003091-uvfppirt	60	14	,	,	,
cord-003091-uvfppirt	60	15	polarize	polarize	VB
cord-003091-uvfppirt	60	16	CD4	CD4	NNP
cord-003091-uvfppirt	60	17	+	+	CC
cord-003091-uvfppirt	60	18	T	t	NN
cord-003091-uvfppirt	60	19	cells	cell	NNS
cord-003091-uvfppirt	60	20	into	into	IN
cord-003091-uvfppirt	60	21	Th	Th	NNP
cord-003091-uvfppirt	60	22	type	type	NN
cord-003091-uvfppirt	60	23	2	2	CD
cord-003091-uvfppirt	60	24	(	(	-LRB-
cord-003091-uvfppirt	60	25	Th2	Th2	NNP
cord-003091-uvfppirt	60	26	)	)	-RRB-
cord-003091-uvfppirt	60	27	cells	cell	NNS
cord-003091-uvfppirt	60	28	that	that	WDT
cord-003091-uvfppirt	60	29	produce	produce	VBP
cord-003091-uvfppirt	60	30	mainly	mainly	RB
cord-003091-uvfppirt	60	31	IL-4	IL-4	NNP
cord-003091-uvfppirt	60	32	.	.	.
cord-003091-uvfppirt	61	1	For	for	IN
cord-003091-uvfppirt	61	2	specialized	specialized	JJ
cord-003091-uvfppirt	61	3	mucosal	mucosal	NN
cord-003091-uvfppirt	61	4	and	and	CC
cord-003091-uvfppirt	61	5	skin	skin	NN
cord-003091-uvfppirt	61	6	immunity	immunity	NN
cord-003091-uvfppirt	61	7	,	,	,
cord-003091-uvfppirt	61	8	DCs	DCs	NNP
cord-003091-uvfppirt	61	9	drive	drive	VBP
cord-003091-uvfppirt	61	10	the	the	DT
cord-003091-uvfppirt	61	11	activation	activation	NN
cord-003091-uvfppirt	61	12	of	of	IN
cord-003091-uvfppirt	61	13	Th	Th	NNP
cord-003091-uvfppirt	61	14	type	type	NN
cord-003091-uvfppirt	61	15	17	17	CD
cord-003091-uvfppirt	61	16	(	(	-LRB-
cord-003091-uvfppirt	61	17	Th17	Th17	NNP
cord-003091-uvfppirt	61	18	)	)	-RRB-
cord-003091-uvfppirt	62	1	(	(	-LRB-
cord-003091-uvfppirt	62	2	29	29	CD
cord-003091-uvfppirt	62	3	)	)	-RRB-
cord-003091-uvfppirt	62	4	.	.	.
cord-003091-uvfppirt	63	1	Thus	thus	RB
cord-003091-uvfppirt	63	2	,	,	,
cord-003091-uvfppirt	63	3	polarization	polarization	NN
cord-003091-uvfppirt	63	4	of	of	IN
cord-003091-uvfppirt	63	5	T	t	NN
cord-003091-uvfppirt	63	6	cells	cell	NNS
cord-003091-uvfppirt	63	7	is	be	VBZ
cord-003091-uvfppirt	63	8	a	a	DT
cord-003091-uvfppirt	63	9	crucial	crucial	JJ
cord-003091-uvfppirt	63	10	event	event	NN
cord-003091-uvfppirt	63	11	that	that	WDT
cord-003091-uvfppirt	63	12	provides	provide	VBZ
cord-003091-uvfppirt	63	13	mechanisms	mechanism	NNS
cord-003091-uvfppirt	63	14	specifically	specifically	RB
cord-003091-uvfppirt	63	15	orchestrated	orchestrate	VBN
cord-003091-uvfppirt	63	16	to	to	TO
cord-003091-uvfppirt	63	17	restore	restore	VB
cord-003091-uvfppirt	63	18	physiological	physiological	JJ
cord-003091-uvfppirt	63	19	homeostasis	homeostasis	NN
cord-003091-uvfppirt	63	20	.	.	.
cord-003091-uvfppirt	64	1	DCs	dc	NNS
cord-003091-uvfppirt	64	2	undergo	undergo	VBP
cord-003091-uvfppirt	64	3	apoptosis	apoptosis	NN
cord-003091-uvfppirt	64	4	once	once	IN
cord-003091-uvfppirt	64	5	they	-PRON-	PRP
cord-003091-uvfppirt	64	6	have	have	VBP
cord-003091-uvfppirt	64	7	fulfilled	fulfil	VBN
cord-003091-uvfppirt	64	8	their	-PRON-	PRP$
cord-003091-uvfppirt	64	9	functions	function	NNS
cord-003091-uvfppirt	64	10	.	.	.
cord-003091-uvfppirt	65	1	The	the	DT
cord-003091-uvfppirt	65	2	rapid	rapid	JJ
cord-003091-uvfppirt	65	3	DC	DC	NNP
cord-003091-uvfppirt	65	4	turnover	turnover	NN
cord-003091-uvfppirt	65	5	after	after	IN
cord-003091-uvfppirt	65	6	activation	activation	NN
cord-003091-uvfppirt	65	7	is	be	VBZ
cord-003091-uvfppirt	65	8	necessary	necessary	JJ
cord-003091-uvfppirt	65	9	to	to	TO
cord-003091-uvfppirt	65	10	avoid	avoid	VB
cord-003091-uvfppirt	65	11	excessive	excessive	JJ
cord-003091-uvfppirt	65	12	T	t	NN
cord-003091-uvfppirt	65	13	cell	cell	NN
cord-003091-uvfppirt	65	14	activation	activation	NN
cord-003091-uvfppirt	65	15	(	(	-LRB-
cord-003091-uvfppirt	65	16	30	30	CD
cord-003091-uvfppirt	65	17	)	)	-RRB-
cord-003091-uvfppirt	65	18	and	and	CC
cord-003091-uvfppirt	65	19	to	to	TO
cord-003091-uvfppirt	65	20	maintain	maintain	VB
cord-003091-uvfppirt	65	21	self	self	NN
cord-003091-uvfppirt	65	22	-	-	HYPH
cord-003091-uvfppirt	65	23	tolerance	tolerance	NN
cord-003091-uvfppirt	65	24	(	(	-LRB-
cord-003091-uvfppirt	65	25	31	31	CD
cord-003091-uvfppirt	65	26	,	,	,
cord-003091-uvfppirt	65	27	32	32	CD
cord-003091-uvfppirt	65	28	)	)	-RRB-
cord-003091-uvfppirt	65	29	.	.	.
cord-003091-uvfppirt	66	1	T	T	NNP
cord-003091-uvfppirt	66	2	lymphocyte	lymphocyte	NN
cord-003091-uvfppirt	66	3	activation	activation	NN
cord-003091-uvfppirt	66	4	culminates	culminate	VBZ
cord-003091-uvfppirt	66	5	with	with	IN
cord-003091-uvfppirt	66	6	the	the	DT
cord-003091-uvfppirt	66	7	establishment	establishment	NN
cord-003091-uvfppirt	66	8	of	of	IN
cord-003091-uvfppirt	66	9	the	the	DT
cord-003091-uvfppirt	66	10	immunological	immunological	JJ
cord-003091-uvfppirt	66	11	memory	memory	NN
cord-003091-uvfppirt	66	12	,	,	,
cord-003091-uvfppirt	66	13	providing	provide	VBG
cord-003091-uvfppirt	66	14	the	the	DT
cord-003091-uvfppirt	66	15	host	host	NN
cord-003091-uvfppirt	66	16	with	with	IN
cord-003091-uvfppirt	66	17	T	T	NNP
cord-003091-uvfppirt	66	18	cells	cell	NNS
cord-003091-uvfppirt	66	19	more	more	RBR
cord-003091-uvfppirt	66	20	prone	prone	JJ
cord-003091-uvfppirt	66	21	and	and	CC
cord-003091-uvfppirt	66	22	efficient	efficient	JJ
cord-003091-uvfppirt	66	23	in	in	IN
cord-003091-uvfppirt	66	24	responding	respond	VBG
cord-003091-uvfppirt	66	25	to	to	IN
cord-003091-uvfppirt	66	26	a	a	DT
cord-003091-uvfppirt	66	27	reinfection	reinfection	NN
cord-003091-uvfppirt	66	28	by	by	IN
cord-003091-uvfppirt	66	29	the	the	DT
cord-003091-uvfppirt	66	30	same	same	JJ
cord-003091-uvfppirt	66	31	pathogen	pathogen	NN
cord-003091-uvfppirt	66	32	or	or	CC
cord-003091-uvfppirt	66	33	upon	upon	IN
cord-003091-uvfppirt	66	34	tumor	tumor	NN
cord-003091-uvfppirt	66	35	relapses	relapse	NNS
cord-003091-uvfppirt	66	36	(	(	-LRB-
cord-003091-uvfppirt	66	37	33	33	CD
cord-003091-uvfppirt	66	38	)	)	-RRB-
cord-003091-uvfppirt	66	39	.	.	.
cord-003091-uvfppirt	67	1	Besides	besides	RB
cord-003091-uvfppirt	67	2	,	,	,
cord-003091-uvfppirt	67	3	DCs	DCs	NNP
cord-003091-uvfppirt	67	4	are	be	VBP
cord-003091-uvfppirt	67	5	key	key	JJ
cord-003091-uvfppirt	67	6	players	player	NNS
cord-003091-uvfppirt	67	7	in	in	IN
cord-003091-uvfppirt	67	8	humoral	humoral	JJ
cord-003091-uvfppirt	67	9	responses	response	NNS
cord-003091-uvfppirt	67	10	too	too	RB
cord-003091-uvfppirt	67	11	.	.	.
cord-003091-uvfppirt	68	1	Indeed	indeed	RB
cord-003091-uvfppirt	68	2	,	,	,
cord-003091-uvfppirt	68	3	they	-PRON-	PRP
cord-003091-uvfppirt	68	4	directly	directly	RB
cord-003091-uvfppirt	68	5	interact	interact	VBP
cord-003091-uvfppirt	68	6	with	with	IN
cord-003091-uvfppirt	68	7	B	b	NN
cord-003091-uvfppirt	68	8	cells	cell	NNS
cord-003091-uvfppirt	68	9	and	and	CC
cord-003091-uvfppirt	68	10	indirectly	indirectly	RB
cord-003091-uvfppirt	68	11	support	support	VBP
cord-003091-uvfppirt	68	12	them	-PRON-	PRP
cord-003091-uvfppirt	68	13	by	by	IN
cord-003091-uvfppirt	68	14	activating	activate	VBG
cord-003091-uvfppirt	68	15	CD4	CD4	NNP
cord-003091-uvfppirt	68	16	+	+	CC
cord-003091-uvfppirt	68	17	T	t	NN
cord-003091-uvfppirt	68	18	cells	cell	NNS
cord-003091-uvfppirt	68	19	,	,	,
cord-003091-uvfppirt	68	20	leading	lead	VBG
cord-003091-uvfppirt	68	21	to	to	IN
cord-003091-uvfppirt	68	22	humoral	humoral	JJ
cord-003091-uvfppirt	68	23	memory	memory	NN
cord-003091-uvfppirt	68	24	.	.	.
cord-003091-uvfppirt	69	1	All	all	PDT
cord-003091-uvfppirt	69	2	these	these	DT
cord-003091-uvfppirt	69	3	notions	notion	NNS
cord-003091-uvfppirt	69	4	strengthen	strengthen	VBP
cord-003091-uvfppirt	69	5	the	the	DT
cord-003091-uvfppirt	69	6	idea	idea	NN
cord-003091-uvfppirt	69	7	that	that	IN
cord-003091-uvfppirt	69	8	DCs	DCs	NNP
cord-003091-uvfppirt	69	9	represent	represent	VBP
cord-003091-uvfppirt	69	10	an	an	DT
cord-003091-uvfppirt	69	11	optimal	optimal	JJ
cord-003091-uvfppirt	69	12	target	target	NN
cord-003091-uvfppirt	69	13	for	for	IN
cord-003091-uvfppirt	69	14	immunotherapies	immunotherapy	NNS
cord-003091-uvfppirt	69	15	and	and	CC
cord-003091-uvfppirt	69	16	vaccines	vaccine	NNS
cord-003091-uvfppirt	69	17	,	,	,
cord-003091-uvfppirt	69	18	acting	act	VBG
cord-003091-uvfppirt	69	19	at	at	IN
cord-003091-uvfppirt	69	20	the	the	DT
cord-003091-uvfppirt	69	21	interface	interface	NN
cord-003091-uvfppirt	69	22	of	of	IN
cord-003091-uvfppirt	69	23	innate	innate	JJ
cord-003091-uvfppirt	69	24	and	and	CC
cord-003091-uvfppirt	69	25	adaptive	adaptive	JJ
cord-003091-uvfppirt	69	26	immunity	immunity	NN
cord-003091-uvfppirt	69	27	.	.	.
cord-003091-uvfppirt	70	1	To	to	TO
cord-003091-uvfppirt	70	2	harness	harness	VB
cord-003091-uvfppirt	70	3	robust	robust	JJ
cord-003091-uvfppirt	70	4	responses	response	NNS
cord-003091-uvfppirt	70	5	through	through	IN
cord-003091-uvfppirt	70	6	DC	DC	NNP
cord-003091-uvfppirt	70	7	-	-	HYPH
cord-003091-uvfppirt	70	8	targeting	target	VBG
cord-003091-uvfppirt	70	9	vaccinations	vaccination	NNS
cord-003091-uvfppirt	70	10	,	,	,
cord-003091-uvfppirt	70	11	DC	DC	NNP
cord-003091-uvfppirt	70	12	maturation	maturation	NN
cord-003091-uvfppirt	70	13	is	be	VBZ
cord-003091-uvfppirt	70	14	essential	essential	JJ
cord-003091-uvfppirt	70	15	.	.	.
cord-003091-uvfppirt	71	1	Adjuvants	adjuvant	NNS
cord-003091-uvfppirt	71	2	become	become	VBP
cord-003091-uvfppirt	71	3	compulsory	compulsory	JJ
cord-003091-uvfppirt	71	4	complement	complement	NN
cord-003091-uvfppirt	71	5	of	of	IN
cord-003091-uvfppirt	71	6	inactivated	inactivate	VBN
cord-003091-uvfppirt	71	7	or	or	CC
cord-003091-uvfppirt	71	8	subunit	subunit	NN
cord-003091-uvfppirt	71	9	vaccines	vaccine	NNS
cord-003091-uvfppirt	71	10	that	that	WDT
cord-003091-uvfppirt	71	11	may	may	MD
cord-003091-uvfppirt	71	12	promote	promote	VB
cord-003091-uvfppirt	71	13	suboptimal	suboptimal	JJ
cord-003091-uvfppirt	71	14	responses	response	NNS
cord-003091-uvfppirt	71	15	.	.	.
cord-003091-uvfppirt	72	1	Furthermore	furthermore	RB
cord-003091-uvfppirt	72	2	,	,	,
cord-003091-uvfppirt	72	3	they	-PRON-	PRP
cord-003091-uvfppirt	72	4	improve	improve	VBP
cord-003091-uvfppirt	72	5	DC	DC	NNP
cord-003091-uvfppirt	72	6	migration	migration	NN
cord-003091-uvfppirt	72	7	,	,	,
cord-003091-uvfppirt	72	8	ag	ag	NNP
cord-003091-uvfppirt	72	9	availability	availability	NN
cord-003091-uvfppirt	72	10	,	,	,
cord-003091-uvfppirt	72	11	and	and	CC
cord-003091-uvfppirt	72	12	specific	specific	JJ
cord-003091-uvfppirt	72	13	targeting	targeting	NN
cord-003091-uvfppirt	72	14	.	.	.
cord-003091-uvfppirt	73	1	Although	although	IN
cord-003091-uvfppirt	73	2	it	-PRON-	PRP
cord-003091-uvfppirt	73	3	seems	seem	VBZ
cord-003091-uvfppirt	73	4	clear	clear	JJ
cord-003091-uvfppirt	73	5	that	that	IN
cord-003091-uvfppirt	73	6	immunization	immunization	NN
cord-003091-uvfppirt	73	7	could	could	MD
cord-003091-uvfppirt	73	8	benefit	benefit	VB
cord-003091-uvfppirt	73	9	from	from	IN
cord-003091-uvfppirt	73	10	adjuvant	adjuvant	NN
cord-003091-uvfppirt	73	11	uses	use	NNS
cord-003091-uvfppirt	73	12	,	,	,
cord-003091-uvfppirt	73	13	the	the	DT
cord-003091-uvfppirt	73	14	solely	solely	RB
cord-003091-uvfppirt	73	15	adjuvant	adjuvant	JJ
cord-003091-uvfppirt	73	16	licensed	license	VBN
cord-003091-uvfppirt	73	17	in	in	IN
cord-003091-uvfppirt	73	18	clinics	clinic	NNS
cord-003091-uvfppirt	73	19	,	,	,
cord-003091-uvfppirt	73	20	until	until	IN
cord-003091-uvfppirt	73	21	recently	recently	RB
cord-003091-uvfppirt	73	22	,	,	,
cord-003091-uvfppirt	73	23	was	be	VBD
cord-003091-uvfppirt	73	24	alum	alum	NN
cord-003091-uvfppirt	73	25	(	(	-LRB-
cord-003091-uvfppirt	73	26	34	34	CD
cord-003091-uvfppirt	73	27	)	)	-RRB-
cord-003091-uvfppirt	73	28	.	.	.
cord-003091-uvfppirt	74	1	Despite	despite	IN
cord-003091-uvfppirt	74	2	alum	alum	NN
cord-003091-uvfppirt	74	3	has	have	VBZ
cord-003091-uvfppirt	74	4	been	be	VBN
cord-003091-uvfppirt	74	5	used	use	VBN
cord-003091-uvfppirt	74	6	in	in	IN
cord-003091-uvfppirt	74	7	vaccination	vaccination	NN
cord-003091-uvfppirt	74	8	practice	practice	NN
cord-003091-uvfppirt	74	9	since	since	IN
cord-003091-uvfppirt	74	10	the	the	DT
cord-003091-uvfppirt	74	11	beginning	beginning	NN
cord-003091-uvfppirt	74	12	of	of	IN
cord-003091-uvfppirt	74	13	the	the	DT
cord-003091-uvfppirt	74	14	last	last	JJ
cord-003091-uvfppirt	74	15	century	century	NN
cord-003091-uvfppirt	74	16	,	,	,
cord-003091-uvfppirt	74	17	the	the	DT
cord-003091-uvfppirt	74	18	mechanism	mechanism	NN
cord-003091-uvfppirt	74	19	through	through	IN
cord-003091-uvfppirt	74	20	which	which	WDT
cord-003091-uvfppirt	74	21	it	-PRON-	PRP
cord-003091-uvfppirt	74	22	activates	activate	VBZ
cord-003091-uvfppirt	74	23	innate	innate	JJ
cord-003091-uvfppirt	74	24	immunity	immunity	NN
cord-003091-uvfppirt	74	25	for	for	IN
cord-003091-uvfppirt	74	26	the	the	DT
cord-003091-uvfppirt	74	27	subsequent	subsequent	JJ
cord-003091-uvfppirt	74	28	activation	activation	NN
cord-003091-uvfppirt	74	29	of	of	IN
cord-003091-uvfppirt	74	30	adaptive	adaptive	JJ
cord-003091-uvfppirt	74	31	immune	immune	JJ
cord-003091-uvfppirt	74	32	responses	response	NNS
cord-003091-uvfppirt	74	33	remains	remain	VBZ
cord-003091-uvfppirt	74	34	elusive	elusive	JJ
cord-003091-uvfppirt	74	35	.	.	.
cord-003091-uvfppirt	75	1	The	the	DT
cord-003091-uvfppirt	75	2	adjuvant	adjuvant	JJ
cord-003091-uvfppirt	75	3	properties	property	NNS
cord-003091-uvfppirt	75	4	of	of	IN
cord-003091-uvfppirt	75	5	alum	alum	NN
cord-003091-uvfppirt	75	6	were	be	VBD
cord-003091-uvfppirt	75	7	initially	initially	RB
cord-003091-uvfppirt	75	8	attributed	attribute	VBN
cord-003091-uvfppirt	75	9	to	to	IN
cord-003091-uvfppirt	75	10	the	the	DT
cord-003091-uvfppirt	75	11	activation	activation	NN
cord-003091-uvfppirt	75	12	of	of	IN
cord-003091-uvfppirt	75	13	NLRP3	NLRP3	NNP
cord-003091-uvfppirt	75	14	inflammasome	inflammasome	NNP
cord-003091-uvfppirt	75	15	(	(	-LRB-
cord-003091-uvfppirt	75	16	35	35	CD
cord-003091-uvfppirt	75	17	,	,	,
cord-003091-uvfppirt	75	18	36	36	CD
cord-003091-uvfppirt	75	19	)	)	-RRB-
cord-003091-uvfppirt	75	20	;	;	:
cord-003091-uvfppirt	75	21	nevertheless	nevertheless	RB
cord-003091-uvfppirt	75	22	,	,	,
cord-003091-uvfppirt	75	23	further	further	JJ
cord-003091-uvfppirt	75	24	studies	study	NNS
cord-003091-uvfppirt	75	25	have	have	VBP
cord-003091-uvfppirt	75	26	clearly	clearly	RB
cord-003091-uvfppirt	75	27	shown	show	VBN
cord-003091-uvfppirt	75	28	the	the	DT
cord-003091-uvfppirt	75	29	dispensability	dispensability	NN
cord-003091-uvfppirt	75	30	of	of	IN
cord-003091-uvfppirt	75	31	NLRP3	NLRP3	NNP
cord-003091-uvfppirt	75	32	and	and	CC
cord-003091-uvfppirt	75	33	caspase-1	caspase-1	NNP
cord-003091-uvfppirt	75	34	for	for	IN
cord-003091-uvfppirt	75	35	the	the	DT
cord-003091-uvfppirt	75	36	generation	generation	NN
cord-003091-uvfppirt	75	37	of	of	IN
cord-003091-uvfppirt	75	38	responses	response	NNS
cord-003091-uvfppirt	75	39	in	in	IN
cord-003091-uvfppirt	75	40	the	the	DT
cord-003091-uvfppirt	75	41	presence	presence	NN
cord-003091-uvfppirt	75	42	of	of	IN
cord-003091-uvfppirt	75	43	this	this	DT
cord-003091-uvfppirt	75	44	adjuvant	adjuvant	NN
cord-003091-uvfppirt	75	45	(	(	-LRB-
cord-003091-uvfppirt	75	46	37	37	CD
cord-003091-uvfppirt	75	47	,	,	,
cord-003091-uvfppirt	75	48	38	38	CD
cord-003091-uvfppirt	75	49	)	)	-RRB-
cord-003091-uvfppirt	75	50	.	.	.
cord-003091-uvfppirt	76	1	TLR	TLR	NNP
cord-003091-uvfppirt	76	2	signaling	signaling	NN
cord-003091-uvfppirt	76	3	is	be	VBZ
cord-003091-uvfppirt	76	4	also	also	RB
cord-003091-uvfppirt	76	5	dispensable	dispensable	JJ
cord-003091-uvfppirt	76	6	for	for	IN
cord-003091-uvfppirt	76	7	alum	alum	NN
cord-003091-uvfppirt	76	8	adjuvanticity	adjuvanticity	NN
cord-003091-uvfppirt	76	9	(	(	-LRB-
cord-003091-uvfppirt	76	10	39	39	CD
cord-003091-uvfppirt	76	11	)	)	-RRB-
cord-003091-uvfppirt	76	12	as	as	RB
cord-003091-uvfppirt	76	13	well	well	RB
cord-003091-uvfppirt	76	14	as	as	IN
cord-003091-uvfppirt	76	15	mast	mast	NN
cord-003091-uvfppirt	76	16	cells	cell	NNS
cord-003091-uvfppirt	76	17	,	,	,
cord-003091-uvfppirt	76	18	eosinophils	eosinophil	NNS
cord-003091-uvfppirt	76	19	,	,	,
cord-003091-uvfppirt	76	20	or	or	CC
cord-003091-uvfppirt	76	21	macrophages	macrophage	NNS
cord-003091-uvfppirt	76	22	(	(	-LRB-
cord-003091-uvfppirt	76	23	40	40	CD
cord-003091-uvfppirt	76	24	)	)	-RRB-
cord-003091-uvfppirt	76	25	.	.	.
cord-003091-uvfppirt	77	1	Recently	recently	RB
cord-003091-uvfppirt	77	2	,	,	,
cord-003091-uvfppirt	77	3	it	-PRON-	PRP
cord-003091-uvfppirt	77	4	has	have	VBZ
cord-003091-uvfppirt	77	5	been	be	VBN
cord-003091-uvfppirt	77	6	proposed	propose	VBN
cord-003091-uvfppirt	77	7	that	that	IN
cord-003091-uvfppirt	77	8	upon	upon	IN
cord-003091-uvfppirt	77	9	contact	contact	NN
cord-003091-uvfppirt	77	10	with	with	IN
cord-003091-uvfppirt	77	11	alum	alum	NN
cord-003091-uvfppirt	77	12	,	,	,
cord-003091-uvfppirt	77	13	DCs	DCs	NNP
cord-003091-uvfppirt	77	14	produce	produce	VBP
cord-003091-uvfppirt	77	15	IL-2	IL-2	NNP
cord-003091-uvfppirt	77	16	through	through	IN
cord-003091-uvfppirt	77	17	the	the	DT
cord-003091-uvfppirt	77	18	activation	activation	NN
cord-003091-uvfppirt	77	19	of	of	IN
cord-003091-uvfppirt	77	20	src	src	NNP
cord-003091-uvfppirt	77	21	and	and	CC
cord-003091-uvfppirt	77	22	Syk	Syk	NNP
cord-003091-uvfppirt	77	23	kinases	kinase	NNS
cord-003091-uvfppirt	77	24	,	,	,
cord-003091-uvfppirt	77	25	Ca	ca	NN
cord-003091-uvfppirt	77	26	2	2	CD
cord-003091-uvfppirt	77	27	+	+	CC
cord-003091-uvfppirt	77	28	mobilization	mobilization	NN
cord-003091-uvfppirt	77	29	,	,	,
cord-003091-uvfppirt	77	30	and	and	CC
cord-003091-uvfppirt	77	31	NFAT	NFAT	NNP
cord-003091-uvfppirt	77	32	nuclear	nuclear	JJ
cord-003091-uvfppirt	77	33	translocation	translocation	NN
cord-003091-uvfppirt	77	34	.	.	.
cord-003091-uvfppirt	78	1	IL-2	IL-2	NNP
cord-003091-uvfppirt	78	2	,	,	,
cord-003091-uvfppirt	78	3	in	in	IN
cord-003091-uvfppirt	78	4	turn	turn	NN
cord-003091-uvfppirt	78	5	,	,	,
cord-003091-uvfppirt	78	6	is	be	VBZ
cord-003091-uvfppirt	78	7	required	require	VBN
cord-003091-uvfppirt	78	8	for	for	IN
cord-003091-uvfppirt	78	9	optimal	optimal	JJ
cord-003091-uvfppirt	78	10	T	t	NN
cord-003091-uvfppirt	78	11	cell	cell	NN
cord-003091-uvfppirt	78	12	priming	priming	NN
cord-003091-uvfppirt	78	13	,	,	,
cord-003091-uvfppirt	78	14	activation	activation	NN
cord-003091-uvfppirt	78	15	,	,	,
cord-003091-uvfppirt	78	16	and	and	CC
cord-003091-uvfppirt	78	17	antibody	antibody	NN
cord-003091-uvfppirt	78	18	production	production	NN
cord-003091-uvfppirt	78	19	(	(	-LRB-
cord-003091-uvfppirt	78	20	41	41	CD
cord-003091-uvfppirt	78	21	)	)	-RRB-
cord-003091-uvfppirt	78	22	.	.	.
cord-003091-uvfppirt	79	1	In	in	IN
cord-003091-uvfppirt	79	2	addition	addition	NN
cord-003091-uvfppirt	79	3	to	to	IN
cord-003091-uvfppirt	79	4	alum	alum	NN
cord-003091-uvfppirt	79	5	,	,	,
cord-003091-uvfppirt	79	6	other	other	JJ
cord-003091-uvfppirt	79	7	chemical	chemical	NN
cord-003091-uvfppirt	79	8	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	79	9	have	have	VBP
cord-003091-uvfppirt	79	10	been	be	VBN
cord-003091-uvfppirt	79	11	tested	test	VBN
cord-003091-uvfppirt	79	12	in	in	IN
cord-003091-uvfppirt	79	13	preclinical	preclinical	JJ
cord-003091-uvfppirt	79	14	models	model	NNS
cord-003091-uvfppirt	79	15	,	,	,
cord-003091-uvfppirt	79	16	showing	show	VBG
cord-003091-uvfppirt	79	17	a	a	DT
cord-003091-uvfppirt	79	18	clear	clear	JJ
cord-003091-uvfppirt	79	19	heterogeneity	heterogeneity	NN
cord-003091-uvfppirt	79	20	in	in	IN
cord-003091-uvfppirt	79	21	the	the	DT
cord-003091-uvfppirt	79	22	responses	response	NNS
cord-003091-uvfppirt	79	23	driven	drive	VBN
cord-003091-uvfppirt	79	24	by	by	IN
cord-003091-uvfppirt	79	25	different	different	JJ
cord-003091-uvfppirt	79	26	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	79	27	,	,	,
cord-003091-uvfppirt	79	28	independently	independently	RB
cord-003091-uvfppirt	79	29	of	of	IN
cord-003091-uvfppirt	79	30	the	the	DT
cord-003091-uvfppirt	79	31	ag	ag	NNP
cord-003091-uvfppirt	79	32	(	(	-LRB-
cord-003091-uvfppirt	79	33	42	42	CD
cord-003091-uvfppirt	79	34	)	)	-RRB-
cord-003091-uvfppirt	79	35	.	.	.
cord-003091-uvfppirt	80	1	This	this	DT
cord-003091-uvfppirt	80	2	underlies	underlie	VBZ
cord-003091-uvfppirt	80	3	the	the	DT
cord-003091-uvfppirt	80	4	need	need	NN
cord-003091-uvfppirt	80	5	of	of	IN
cord-003091-uvfppirt	80	6	deepening	deepen	VBG
cord-003091-uvfppirt	80	7	our	-PRON-	PRP$
cord-003091-uvfppirt	80	8	knowledge	knowledge	NN
cord-003091-uvfppirt	80	9	on	on	IN
cord-003091-uvfppirt	80	10	these	these	DT
cord-003091-uvfppirt	80	11	powerful	powerful	JJ
cord-003091-uvfppirt	80	12	tools	tool	NNS
cord-003091-uvfppirt	80	13	to	to	TO
cord-003091-uvfppirt	80	14	drive	drive	VB
cord-003091-uvfppirt	80	15	immune	immune	JJ
cord-003091-uvfppirt	80	16	responses	response	NNS
cord-003091-uvfppirt	80	17	.	.	.
cord-003091-uvfppirt	81	1	Indeed	indeed	RB
cord-003091-uvfppirt	81	2	,	,	,
cord-003091-uvfppirt	81	3	MF59	MF59	NNP
cord-003091-uvfppirt	81	4	,	,	,
cord-003091-uvfppirt	81	5	an	an	DT
cord-003091-uvfppirt	81	6	oil	oil	NN
cord-003091-uvfppirt	81	7	-	-	HYPH
cord-003091-uvfppirt	81	8	in	in	IN
cord-003091-uvfppirt	81	9	-	-	HYPH
cord-003091-uvfppirt	81	10	water	water	NN
cord-003091-uvfppirt	81	11	emulsion	emulsion	NN
cord-003091-uvfppirt	81	12	adjuvant	adjuvant	NN
cord-003091-uvfppirt	81	13	,	,	,
cord-003091-uvfppirt	81	14	that	that	WDT
cord-003091-uvfppirt	81	15	allows	allow	VBZ
cord-003091-uvfppirt	81	16	long	long	RB
cord-003091-uvfppirt	81	17	-	-	HYPH
cord-003091-uvfppirt	81	18	lasting	last	VBG
cord-003091-uvfppirt	81	19	ag	ag	NNP
cord-003091-uvfppirt	81	20	retention	retention	NN
cord-003091-uvfppirt	81	21	in	in	IN
cord-003091-uvfppirt	81	22	draining	drain	VBG
cord-003091-uvfppirt	81	23	LN	LN	NNP
cord-003091-uvfppirt	81	24	and	and	CC
cord-003091-uvfppirt	81	25	enhanced	enhance	VBN
cord-003091-uvfppirt	81	26	ag	ag	NNP
cord-003091-uvfppirt	81	27	uptake	uptake	NN
cord-003091-uvfppirt	81	28	by	by	IN
cord-003091-uvfppirt	81	29	LN	ln	NN
cord-003091-uvfppirt	81	30	-	-	HYPH
cord-003091-uvfppirt	81	31	resident	resident	JJ
cord-003091-uvfppirt	81	32	DCs	dc	NNS
cord-003091-uvfppirt	81	33	,	,	,
cord-003091-uvfppirt	81	34	promotes	promote	VBZ
cord-003091-uvfppirt	81	35	robust	robust	JJ
cord-003091-uvfppirt	81	36	humoral	humoral	JJ
cord-003091-uvfppirt	81	37	responses	response	NNS
cord-003091-uvfppirt	81	38	via	via	IN
cord-003091-uvfppirt	81	39	follicular	follicular	JJ
cord-003091-uvfppirt	81	40	DC	DC	NNP
cord-003091-uvfppirt	81	41	activation	activation	NN
cord-003091-uvfppirt	81	42	(	(	-LRB-
cord-003091-uvfppirt	81	43	43	43	CD
cord-003091-uvfppirt	81	44	)	)	-RRB-
cord-003091-uvfppirt	81	45	and	and	CC
cord-003091-uvfppirt	81	46	CD4	CD4	NNP
cord-003091-uvfppirt	81	47	+	+	CC
cord-003091-uvfppirt	81	48	T	T	NNP
cord-003091-uvfppirt	81	49	cell	cell	NN
cord-003091-uvfppirt	81	50	immunity	immunity	NN
cord-003091-uvfppirt	81	51	induction	induction	NN
cord-003091-uvfppirt	81	52	(	(	-LRB-
cord-003091-uvfppirt	81	53	44	44	CD
cord-003091-uvfppirt	81	54	)	)	-RRB-
cord-003091-uvfppirt	81	55	.	.	.
cord-003091-uvfppirt	82	1	Conversely	conversely	RB
cord-003091-uvfppirt	82	2	,	,	,
cord-003091-uvfppirt	82	3	IC31	IC31	NNP
cord-003091-uvfppirt	82	4	adjuvant	adjuvant	NN
cord-003091-uvfppirt	82	5	,	,	,
cord-003091-uvfppirt	82	6	which	which	WDT
cord-003091-uvfppirt	82	7	consists	consist	VBZ
cord-003091-uvfppirt	82	8	of	of	IN
cord-003091-uvfppirt	82	9	an	an	DT
cord-003091-uvfppirt	82	10	antibacterial	antibacterial	JJ
cord-003091-uvfppirt	82	11	peptide	peptide	NN
cord-003091-uvfppirt	82	12	and	and	CC
cord-003091-uvfppirt	82	13	a	a	DT
cord-003091-uvfppirt	82	14	synthetic	synthetic	JJ
cord-003091-uvfppirt	82	15	oligodeoxynucleotide	oligodeoxynucleotide	NN
cord-003091-uvfppirt	82	16	(	(	-LRB-
cord-003091-uvfppirt	82	17	ODN	ODN	NNP
cord-003091-uvfppirt	82	18	)	)	-RRB-
cord-003091-uvfppirt	82	19	,	,	,
cord-003091-uvfppirt	82	20	elicits	elicit	VBZ
cord-003091-uvfppirt	82	21	IFN	IFN	NNP
cord-003091-uvfppirt	82	22	-	-	HYPH
cord-003091-uvfppirt	82	23	β	β	NNP
cord-003091-uvfppirt	82	24	release	release	NN
cord-003091-uvfppirt	82	25	by	by	IN
cord-003091-uvfppirt	82	26	human	human	JJ
cord-003091-uvfppirt	82	27	DCs	dc	NNS
cord-003091-uvfppirt	82	28	via	via	IN
cord-003091-uvfppirt	82	29	engagement	engagement	NN
cord-003091-uvfppirt	82	30	of	of	IN
cord-003091-uvfppirt	82	31	endosomal	endosomal	NNP
cord-003091-uvfppirt	82	32	TLRs	TLRs	NNP
cord-003091-uvfppirt	82	33	supporting	support	VBG
cord-003091-uvfppirt	82	34	immunity	immunity	NN
cord-003091-uvfppirt	82	35	against	against	IN
cord-003091-uvfppirt	82	36	intracellular	intracellular	JJ
cord-003091-uvfppirt	82	37	pathogens	pathogen	NNS
cord-003091-uvfppirt	82	38	and	and	CC
cord-003091-uvfppirt	82	39	cancer	cancer	NN
cord-003091-uvfppirt	82	40	(	(	-LRB-
cord-003091-uvfppirt	82	41	45	45	CD
cord-003091-uvfppirt	82	42	)	)	-RRB-
cord-003091-uvfppirt	82	43	.	.	.
cord-003091-uvfppirt	83	1	In	in	IN
cord-003091-uvfppirt	83	2	the	the	DT
cord-003091-uvfppirt	83	3	last	last	JJ
cord-003091-uvfppirt	83	4	decades	decade	NNS
cord-003091-uvfppirt	83	5	,	,	,
cord-003091-uvfppirt	83	6	attention	attention	NN
cord-003091-uvfppirt	83	7	has	have	VBZ
cord-003091-uvfppirt	83	8	been	be	VBN
cord-003091-uvfppirt	83	9	focused	focus	VBN
cord-003091-uvfppirt	83	10	on	on	IN
cord-003091-uvfppirt	83	11	TLR	TLR	NNP
cord-003091-uvfppirt	83	12	ligands	ligand	NNS
cord-003091-uvfppirt	83	13	as	as	IN
cord-003091-uvfppirt	83	14	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	83	15	.	.	.
cord-003091-uvfppirt	84	1	Currently	currently	RB
cord-003091-uvfppirt	84	2	,	,	,
cord-003091-uvfppirt	84	3	several	several	JJ
cord-003091-uvfppirt	84	4	compounds	compound	NNS
cord-003091-uvfppirt	84	5	are	be	VBP
cord-003091-uvfppirt	84	6	under	under	IN
cord-003091-uvfppirt	84	7	investigation	investigation	NN
cord-003091-uvfppirt	84	8	:	:	:
cord-003091-uvfppirt	84	9	Pam2CSK4	Pam2CSK4	NNP
cord-003091-uvfppirt	84	10	,	,	,
cord-003091-uvfppirt	84	11	Pam3CSK4	Pam3CSK4	NNP
cord-003091-uvfppirt	84	12	,	,	,
cord-003091-uvfppirt	84	13	or	or	CC
cord-003091-uvfppirt	84	14	analogs	analog	NNS
cord-003091-uvfppirt	84	15	as	as	IN
cord-003091-uvfppirt	84	16	TLR2/6	TLR2/6	NNP
cord-003091-uvfppirt	84	17	or	or	CC
cord-003091-uvfppirt	84	18	TLR2/1	tlr2/1	IN
cord-003091-uvfppirt	84	19	ligands	ligand	NNS
cord-003091-uvfppirt	84	20	(	(	-LRB-
cord-003091-uvfppirt	84	21	46	46	CD
cord-003091-uvfppirt	84	22	,	,	,
cord-003091-uvfppirt	84	23	47	47	CD
cord-003091-uvfppirt	84	24	)	)	-RRB-
cord-003091-uvfppirt	84	25	,	,	,
cord-003091-uvfppirt	84	26	Poly(I	Poly(I	NNP
cord-003091-uvfppirt	84	27	:	:	:
cord-003091-uvfppirt	84	28	C	C	NNP
cord-003091-uvfppirt	84	29	)	)	-RRB-
cord-003091-uvfppirt	84	30	and	and	CC
cord-003091-uvfppirt	84	31	similar	similar	JJ
cord-003091-uvfppirt	84	32	compounds	compound	NNS
cord-003091-uvfppirt	84	33	acting	act	VBG
cord-003091-uvfppirt	84	34	on	on	IN
cord-003091-uvfppirt	84	35	TLR3	TLR3	NNP
cord-003091-uvfppirt	84	36	(	(	-LRB-
cord-003091-uvfppirt	84	37	48	48	CD
cord-003091-uvfppirt	84	38	,	,	,
cord-003091-uvfppirt	84	39	49	49	CD
cord-003091-uvfppirt	84	40	)	)	-RRB-
cord-003091-uvfppirt	84	41	,	,	,
cord-003091-uvfppirt	84	42	TLR4	TLR4	NNP
cord-003091-uvfppirt	84	43	agonists	agonist	NNS
cord-003091-uvfppirt	84	44	(	(	-LRB-
cord-003091-uvfppirt	84	45	50	50	CD
cord-003091-uvfppirt	84	46	)	)	-RRB-
cord-003091-uvfppirt	84	47	,	,	.
cord-003091-uvfppirt	85	1	Flagellin	flagellin	JJ
cord-003091-uvfppirt	85	2	acting	act	VBG
cord-003091-uvfppirt	85	3	on	on	IN
cord-003091-uvfppirt	85	4	TLR5	TLR5	NNP
cord-003091-uvfppirt	85	5	(	(	-LRB-
cord-003091-uvfppirt	85	6	51	51	CD
cord-003091-uvfppirt	85	7	)	)	-RRB-
cord-003091-uvfppirt	85	8	,	,	,
cord-003091-uvfppirt	85	9	Imiquimod	Imiquimod	NNP
cord-003091-uvfppirt	85	10	and	and	CC
cord-003091-uvfppirt	85	11	other	other	JJ
cord-003091-uvfppirt	85	12	TLR7	TLR7	NNP
cord-003091-uvfppirt	85	13	ligands	ligand	NNS
cord-003091-uvfppirt	85	14	(	(	-LRB-
cord-003091-uvfppirt	85	15	52	52	CD
cord-003091-uvfppirt	85	16	,	,	,
cord-003091-uvfppirt	85	17	53	53	CD
cord-003091-uvfppirt	85	18	)	)	-RRB-
cord-003091-uvfppirt	85	19	,	,	,
cord-003091-uvfppirt	85	20	TLR8	TLR8	NNP
cord-003091-uvfppirt	85	21	agonists	agonist	NNS
cord-003091-uvfppirt	85	22	(	(	-LRB-
cord-003091-uvfppirt	85	23	54	54	CD
cord-003091-uvfppirt	85	24	)	)	-RRB-
cord-003091-uvfppirt	85	25	,	,	.
cord-003091-uvfppirt	86	1	CpG	CpG	NNP
cord-003091-uvfppirt	86	2	ODN	ODN	NNP
cord-003091-uvfppirt	86	3	binding	bind	VBG
cord-003091-uvfppirt	86	4	TLR9	TLR9	NNP
cord-003091-uvfppirt	86	5	(	(	-LRB-
cord-003091-uvfppirt	86	6	55	55	CD
cord-003091-uvfppirt	86	7	,	,	,
cord-003091-uvfppirt	86	8	56	56	CD
cord-003091-uvfppirt	86	9	)	)	-RRB-
cord-003091-uvfppirt	86	10	.	.	.
cord-003091-uvfppirt	87	1	Due	due	IN
cord-003091-uvfppirt	87	2	to	to	IN
cord-003091-uvfppirt	87	3	the	the	DT
cord-003091-uvfppirt	87	4	possible	possible	JJ
cord-003091-uvfppirt	87	5	reactogenicity	reactogenicity	NN
cord-003091-uvfppirt	87	6	that	that	WDT
cord-003091-uvfppirt	87	7	may	may	MD
cord-003091-uvfppirt	87	8	be	be	VB
cord-003091-uvfppirt	87	9	induced	induce	VBN
cord-003091-uvfppirt	87	10	by	by	IN
cord-003091-uvfppirt	87	11	administering	administer	VBG
cord-003091-uvfppirt	87	12	TLR	TLR	NNP
cord-003091-uvfppirt	87	13	agonists	agonist	NNS
cord-003091-uvfppirt	87	14	,	,	,
cord-003091-uvfppirt	87	15	some	some	DT
cord-003091-uvfppirt	87	16	compounds	compound	NNS
cord-003091-uvfppirt	87	17	are	be	VBP
cord-003091-uvfppirt	87	18	chemically	chemically	RB
cord-003091-uvfppirt	87	19	modified	modify	VBN
cord-003091-uvfppirt	87	20	to	to	TO
cord-003091-uvfppirt	87	21	reduce	reduce	VB
cord-003091-uvfppirt	87	22	toxicity	toxicity	NN
cord-003091-uvfppirt	87	23	or	or	CC
cord-003091-uvfppirt	87	24	are	be	VBP
cord-003091-uvfppirt	87	25	delivered	deliver	VBN
cord-003091-uvfppirt	87	26	specifically	specifically	RB
cord-003091-uvfppirt	87	27	to	to	IN
cord-003091-uvfppirt	87	28	the	the	DT
cord-003091-uvfppirt	87	29	DC	DC	NNP
cord-003091-uvfppirt	87	30	subsets	subset	NNS
cord-003091-uvfppirt	87	31	of	of	IN
cord-003091-uvfppirt	87	32	interest	interest	NN
cord-003091-uvfppirt	87	33	,	,	,
cord-003091-uvfppirt	87	34	avoiding	avoid	VBG
cord-003091-uvfppirt	87	35	TLR	TLR	NNP
cord-003091-uvfppirt	87	36	ligand	ligand	NN
cord-003091-uvfppirt	87	37	dissemination	dissemination	NN
cord-003091-uvfppirt	87	38	.	.	.
cord-003091-uvfppirt	88	1	Monophosphoryl	Monophosphoryl	NNP
cord-003091-uvfppirt	88	2	lipid	lipid	VBG
cord-003091-uvfppirt	88	3	A	A	NNP
cord-003091-uvfppirt	88	4	,	,	,
cord-003091-uvfppirt	88	5	a	a	DT
cord-003091-uvfppirt	88	6	low	low	JJ
cord-003091-uvfppirt	88	7	-	-	HYPH
cord-003091-uvfppirt	88	8	toxicity	toxicity	NN
cord-003091-uvfppirt	88	9	molecule	molecule	NN
cord-003091-uvfppirt	88	10	derived	derive	VBN
cord-003091-uvfppirt	88	11	from	from	IN
cord-003091-uvfppirt	88	12	lipopolysaccharide	lipopolysaccharide	NN
cord-003091-uvfppirt	88	13	(	(	-LRB-
cord-003091-uvfppirt	88	14	LPS	LPS	NNP
cord-003091-uvfppirt	88	15	)	)	-RRB-
cord-003091-uvfppirt	88	16	,	,	,
cord-003091-uvfppirt	88	17	displays	display	VBZ
cord-003091-uvfppirt	88	18	promising	promising	JJ
cord-003091-uvfppirt	88	19	effects	effect	NNS
cord-003091-uvfppirt	88	20	for	for	IN
cord-003091-uvfppirt	88	21	vaccine	vaccine	NN
cord-003091-uvfppirt	88	22	design	design	NN
cord-003091-uvfppirt	88	23	(	(	-LRB-
cord-003091-uvfppirt	88	24	57	57	CD
cord-003091-uvfppirt	88	25	)	)	-RRB-
cord-003091-uvfppirt	88	26	even	even	RB
cord-003091-uvfppirt	88	27	though	though	IN
cord-003091-uvfppirt	88	28	it	-PRON-	PRP
cord-003091-uvfppirt	88	29	promotes	promote	VBZ
cord-003091-uvfppirt	88	30	terminal	terminal	JJ
cord-003091-uvfppirt	88	31	differentiation	differentiation	NN
cord-003091-uvfppirt	88	32	of	of	IN
cord-003091-uvfppirt	88	33	CD8	CD8	NNP
cord-003091-uvfppirt	88	34	+	+	CC
cord-003091-uvfppirt	88	35	cells	cell	NNS
cord-003091-uvfppirt	88	36	,	,	,
cord-003091-uvfppirt	88	37	leading	lead	VBG
cord-003091-uvfppirt	88	38	to	to	IN
cord-003091-uvfppirt	88	39	reduced	reduce	VBN
cord-003091-uvfppirt	88	40	memory	memory	NN
cord-003091-uvfppirt	88	41	protection	protection	NN
cord-003091-uvfppirt	88	42	(	(	-LRB-
cord-003091-uvfppirt	88	43	58	58	CD
cord-003091-uvfppirt	88	44	)	)	-RRB-
cord-003091-uvfppirt	88	45	.	.	.
cord-003091-uvfppirt	89	1	Another	another	DT
cord-003091-uvfppirt	89	2	LPS	LPS	NNP
cord-003091-uvfppirt	89	3	-	-	HYPH
cord-003091-uvfppirt	89	4	analog	analog	NN
cord-003091-uvfppirt	89	5	is	be	VBZ
cord-003091-uvfppirt	89	6	7-acyl	7-acyl	CD
cord-003091-uvfppirt	89	7	lipid	lipid	NN
cord-003091-uvfppirt	89	8	A	a	NN
cord-003091-uvfppirt	89	9	that	that	WDT
cord-003091-uvfppirt	89	10	has	have	VBZ
cord-003091-uvfppirt	89	11	emerged	emerge	VBN
cord-003091-uvfppirt	89	12	as	as	IN
cord-003091-uvfppirt	89	13	potent	potent	JJ
cord-003091-uvfppirt	89	14	inducer	inducer	NN
cord-003091-uvfppirt	89	15	of	of	IN
cord-003091-uvfppirt	89	16	IFN	IFN	NNP
cord-003091-uvfppirt	89	17	-	-	HYPH
cord-003091-uvfppirt	89	18	γ	γ	NNP
cord-003091-uvfppirt	89	19	-	-	HYPH
cord-003091-uvfppirt	89	20	mediated	mediate	VBN
cord-003091-uvfppirt	89	21	ag	ag	JJ
cord-003091-uvfppirt	89	22	-	-	HYPH
cord-003091-uvfppirt	89	23	specific	specific	JJ
cord-003091-uvfppirt	89	24	responses	response	NNS
cord-003091-uvfppirt	89	25	when	when	WRB
cord-003091-uvfppirt	89	26	co	co	NN
cord-003091-uvfppirt	89	27	-	-	VBD
cord-003091-uvfppirt	89	28	delivered	deliver	VBN
cord-003091-uvfppirt	89	29	with	with	IN
cord-003091-uvfppirt	89	30	poorly	poorly	RB
cord-003091-uvfppirt	89	31	immunogenic	immunogenic	JJ
cord-003091-uvfppirt	89	32	tumor	tumor	NN
cord-003091-uvfppirt	89	33	ags	ag	NNS
cord-003091-uvfppirt	89	34	(	(	-LRB-
cord-003091-uvfppirt	89	35	59	59	CD
cord-003091-uvfppirt	89	36	)	)	-RRB-
cord-003091-uvfppirt	89	37	.	.	.
cord-003091-uvfppirt	90	1	To	to	TO
cord-003091-uvfppirt	90	2	improve	improve	VB
cord-003091-uvfppirt	90	3	the	the	DT
cord-003091-uvfppirt	90	4	effectiveness	effectiveness	NN
cord-003091-uvfppirt	90	5	and	and	CC
cord-003091-uvfppirt	90	6	strength	strength	NN
cord-003091-uvfppirt	90	7	of	of	IN
cord-003091-uvfppirt	90	8	immunity	immunity	NN
cord-003091-uvfppirt	90	9	,	,	,
cord-003091-uvfppirt	90	10	in	in	IN
cord-003091-uvfppirt	90	11	addition	addition	NN
cord-003091-uvfppirt	90	12	to	to	IN
cord-003091-uvfppirt	90	13	the	the	DT
cord-003091-uvfppirt	90	14	efficiency	efficiency	NN
cord-003091-uvfppirt	90	15	of	of	IN
cord-003091-uvfppirt	90	16	APC	APC	NNP
cord-003091-uvfppirt	90	17	,	,	,
cord-003091-uvfppirt	90	18	activation	activation	NN
cord-003091-uvfppirt	90	19	and	and	CC
cord-003091-uvfppirt	90	20	ag	ag	NN
cord-003091-uvfppirt	90	21	processing	processing	NN
cord-003091-uvfppirt	90	22	and	and	CC
cord-003091-uvfppirt	90	23	presentation	presentation	NN
cord-003091-uvfppirt	90	24	of	of	IN
cord-003091-uvfppirt	90	25	other	other	JJ
cord-003091-uvfppirt	90	26	aspects	aspect	NNS
cord-003091-uvfppirt	90	27	should	should	MD
cord-003091-uvfppirt	90	28	be	be	VB
cord-003091-uvfppirt	90	29	taken	take	VBN
cord-003091-uvfppirt	90	30	into	into	IN
cord-003091-uvfppirt	90	31	account	account	NN
cord-003091-uvfppirt	90	32	.	.	.
cord-003091-uvfppirt	91	1	The	the	DT
cord-003091-uvfppirt	91	2	importance	importance	NN
cord-003091-uvfppirt	91	3	of	of	IN
cord-003091-uvfppirt	91	4	DC	DC	NNP
cord-003091-uvfppirt	91	5	-	-	HYPH
cord-003091-uvfppirt	91	6	derived	derive	VBN
cord-003091-uvfppirt	91	7	IL-2	il-2	NN
cord-003091-uvfppirt	91	8	in	in	IN
cord-003091-uvfppirt	91	9	the	the	DT
cord-003091-uvfppirt	91	10	activation	activation	NN
cord-003091-uvfppirt	91	11	of	of	IN
cord-003091-uvfppirt	91	12	adaptive	adaptive	JJ
cord-003091-uvfppirt	91	13	responses	response	NNS
cord-003091-uvfppirt	91	14	has	have	VBZ
cord-003091-uvfppirt	91	15	been	be	VBN
cord-003091-uvfppirt	91	16	shown	show	VBN
cord-003091-uvfppirt	91	17	not	not	RB
cord-003091-uvfppirt	91	18	only	only	RB
cord-003091-uvfppirt	91	19	in	in	IN
cord-003091-uvfppirt	91	20	alum	alum	NN
cord-003091-uvfppirt	91	21	-	-	HYPH
cord-003091-uvfppirt	91	22	driven	drive	VBN
cord-003091-uvfppirt	91	23	immune	immune	JJ
cord-003091-uvfppirt	91	24	responses	response	NNS
cord-003091-uvfppirt	91	25	and	and	CC
cord-003091-uvfppirt	91	26	in	in	IN
cord-003091-uvfppirt	91	27	mouse	mouse	NN
cord-003091-uvfppirt	91	28	models	model	NNS
cord-003091-uvfppirt	91	29	of	of	IN
cord-003091-uvfppirt	91	30	infections	infection	NNS
cord-003091-uvfppirt	91	31	(	(	-LRB-
cord-003091-uvfppirt	91	32	60	60	CD
cord-003091-uvfppirt	91	33	,	,	,
cord-003091-uvfppirt	91	34	61	61	CD
cord-003091-uvfppirt	91	35	)	)	-RRB-
cord-003091-uvfppirt	91	36	but	but	CC
cord-003091-uvfppirt	91	37	also	also	RB
cord-003091-uvfppirt	91	38	in	in	IN
cord-003091-uvfppirt	91	39	tests	test	NNS
cord-003091-uvfppirt	91	40	of	of	IN
cord-003091-uvfppirt	91	41	human	human	JJ
cord-003091-uvfppirt	91	42	T	t	NN
cord-003091-uvfppirt	91	43	cell	cell	NN
cord-003091-uvfppirt	91	44	priming	prime	VBG
cord-003091-uvfppirt	91	45	in	in	IN
cord-003091-uvfppirt	91	46	the	the	DT
cord-003091-uvfppirt	91	47	presence	presence	NN
cord-003091-uvfppirt	91	48	of	of	IN
cord-003091-uvfppirt	91	49	activatory	activatory	NNP
cord-003091-uvfppirt	91	50	DCs	DCs	NNP
cord-003091-uvfppirt	91	51	.	.	.
cord-003091-uvfppirt	92	1	During	during	IN
cord-003091-uvfppirt	92	2	the	the	DT
cord-003091-uvfppirt	92	3	first	first	JJ
cord-003091-uvfppirt	92	4	few	few	JJ
cord-003091-uvfppirt	92	5	hours	hour	NNS
cord-003091-uvfppirt	92	6	after	after	IN
cord-003091-uvfppirt	92	7	interaction	interaction	NN
cord-003091-uvfppirt	92	8	with	with	IN
cord-003091-uvfppirt	92	9	T	T	NNP
cord-003091-uvfppirt	92	10	cells	cell	NNS
cord-003091-uvfppirt	92	11	,	,	,
cord-003091-uvfppirt	92	12	activatory	activatory	NNP
cord-003091-uvfppirt	92	13	monocyte	monocyte	NNP
cord-003091-uvfppirt	92	14	-	-	HYPH
cord-003091-uvfppirt	92	15	derived	derive	VBN
cord-003091-uvfppirt	92	16	DCs	dc	NNS
cord-003091-uvfppirt	92	17	(	(	-LRB-
cord-003091-uvfppirt	92	18	MoDCs	MoDCs	NNP
cord-003091-uvfppirt	92	19	stimulated	stimulate	VBD
cord-003091-uvfppirt	92	20	with	with	IN
cord-003091-uvfppirt	92	21	the	the	DT
cord-003091-uvfppirt	92	22	cytokine	cytokine	NN
cord-003091-uvfppirt	92	23	cocktail	cocktail	NN
cord-003091-uvfppirt	92	24	,	,	,
cord-003091-uvfppirt	92	25	TNF	TNF	NNP
cord-003091-uvfppirt	92	26	-	-	HYPH
cord-003091-uvfppirt	92	27	α	α	NNP
cord-003091-uvfppirt	92	28	,	,	,
cord-003091-uvfppirt	92	29	IL-6	IL-6	NNP
cord-003091-uvfppirt	92	30	,	,	,
cord-003091-uvfppirt	92	31	IL-1β	IL-1β	NNP
cord-003091-uvfppirt	92	32	,	,	,
cord-003091-uvfppirt	92	33	and	and	CC
cord-003091-uvfppirt	92	34	PGE2	PGE2	NNP
cord-003091-uvfppirt	92	35	)	)	-RRB-
cord-003091-uvfppirt	92	36	produce	produce	VBP
cord-003091-uvfppirt	92	37	IL-2	il-2	NN
cord-003091-uvfppirt	93	1	and	and	CC
cord-003091-uvfppirt	93	2	CD25	CD25	NNP
cord-003091-uvfppirt	93	3	(	(	-LRB-
cord-003091-uvfppirt	93	4	62	62	CD
cord-003091-uvfppirt	93	5	)	)	-RRB-
cord-003091-uvfppirt	93	6	.	.	.
cord-003091-uvfppirt	94	1	DC	DC	NNP
cord-003091-uvfppirt	94	2	-	-	HYPH
cord-003091-uvfppirt	94	3	derived	derive	VBN
cord-003091-uvfppirt	94	4	IL-2	il-2	NN
cord-003091-uvfppirt	94	5	is	be	VBZ
cord-003091-uvfppirt	94	6	,	,	,
cord-003091-uvfppirt	94	7	in	in	IN
cord-003091-uvfppirt	94	8	turn	turn	NN
cord-003091-uvfppirt	94	9	,	,	,
cord-003091-uvfppirt	94	10	trans	trans	NNP
cord-003091-uvfppirt	94	11	-	-	VBD
cord-003091-uvfppirt	94	12	presented	present	VBN
cord-003091-uvfppirt	94	13	to	to	IN
cord-003091-uvfppirt	94	14	T	T	NNP
cord-003091-uvfppirt	94	15	cells	cell	NNS
cord-003091-uvfppirt	94	16	at	at	IN
cord-003091-uvfppirt	94	17	the	the	DT
cord-003091-uvfppirt	94	18	immunological	immunological	JJ
cord-003091-uvfppirt	94	19	synapse	synapse	NN
cord-003091-uvfppirt	94	20	via	via	IN
cord-003091-uvfppirt	94	21	CD25	CD25	NNP
cord-003091-uvfppirt	94	22	.	.	.
cord-003091-uvfppirt	95	1	Since	since	IN
cord-003091-uvfppirt	95	2	naïve	naïve	JJ
cord-003091-uvfppirt	95	3	T	t	NN
cord-003091-uvfppirt	95	4	cells	cell	NNS
cord-003091-uvfppirt	95	5	start	start	VBP
cord-003091-uvfppirt	95	6	to	to	TO
cord-003091-uvfppirt	95	7	express	express	VB
cord-003091-uvfppirt	95	8	CD25	cd25	NN
cord-003091-uvfppirt	96	1	only	only	RB
cord-003091-uvfppirt	96	2	many	many	JJ
cord-003091-uvfppirt	96	3	hours	hour	NNS
cord-003091-uvfppirt	96	4	after	after	IN
cord-003091-uvfppirt	96	5	ag	ag	NNP
cord-003091-uvfppirt	96	6	encounter	encounter	NN
cord-003091-uvfppirt	96	7	,	,	,
cord-003091-uvfppirt	96	8	the	the	DT
cord-003091-uvfppirt	96	9	DC	DC	NNP
cord-003091-uvfppirt	96	10	-	-	HYPH
cord-003091-uvfppirt	96	11	mediated	mediate	VBN
cord-003091-uvfppirt	96	12	presentation	presentation	NN
cord-003091-uvfppirt	96	13	of	of	IN
cord-003091-uvfppirt	96	14	the	the	DT
cord-003091-uvfppirt	96	15	IL-2	IL-2	NNP
cord-003091-uvfppirt	96	16	/	/	SYM
cord-003091-uvfppirt	96	17	CD25	CD25	NNP
cord-003091-uvfppirt	96	18	complex	complex	NN
cord-003091-uvfppirt	96	19	is	be	VBZ
cord-003091-uvfppirt	96	20	indispensable	indispensable	JJ
cord-003091-uvfppirt	96	21	for	for	IN
cord-003091-uvfppirt	96	22	an	an	DT
cord-003091-uvfppirt	96	23	efficient	efficient	JJ
cord-003091-uvfppirt	96	24	T	t	NN
cord-003091-uvfppirt	96	25	cell	cell	NN
cord-003091-uvfppirt	96	26	priming	priming	NN
cord-003091-uvfppirt	96	27	(	(	-LRB-
cord-003091-uvfppirt	96	28	62	62	CD
cord-003091-uvfppirt	96	29	)	)	-RRB-
cord-003091-uvfppirt	96	30	.	.	.
cord-003091-uvfppirt	97	1	It	-PRON-	PRP
cord-003091-uvfppirt	97	2	has	have	VBZ
cord-003091-uvfppirt	97	3	been	be	VBN
cord-003091-uvfppirt	97	4	proposed	propose	VBN
cord-003091-uvfppirt	97	5	that	that	IN
cord-003091-uvfppirt	97	6	this	this	DT
cord-003091-uvfppirt	97	7	is	be	VBZ
cord-003091-uvfppirt	97	8	the	the	DT
cord-003091-uvfppirt	97	9	reason	reason	NN
cord-003091-uvfppirt	97	10	why	why	WRB
cord-003091-uvfppirt	97	11	approved	approve	VBN
cord-003091-uvfppirt	97	12	therapies	therapy	NNS
cord-003091-uvfppirt	97	13	based	base	VBN
cord-003091-uvfppirt	97	14	on	on	IN
cord-003091-uvfppirt	97	15	the	the	DT
cord-003091-uvfppirt	97	16	use	use	NN
cord-003091-uvfppirt	97	17	of	of	IN
cord-003091-uvfppirt	97	18	anti	anti	JJ
cord-003091-uvfppirt	97	19	-	-	JJ
cord-003091-uvfppirt	97	20	CD25	cd25	JJ
cord-003091-uvfppirt	97	21	antibodies	antibody	NNS
cord-003091-uvfppirt	97	22	to	to	TO
cord-003091-uvfppirt	97	23	avoid	avoid	VB
cord-003091-uvfppirt	97	24	the	the	DT
cord-003091-uvfppirt	97	25	acute	acute	JJ
cord-003091-uvfppirt	97	26	phases	phase	NNS
cord-003091-uvfppirt	97	27	of	of	IN
cord-003091-uvfppirt	97	28	autoimmune	autoimmune	JJ
cord-003091-uvfppirt	97	29	diseases	disease	NNS
cord-003091-uvfppirt	97	30	,	,	,
cord-003091-uvfppirt	97	31	or	or	CC
cord-003091-uvfppirt	97	32	acute	acute	JJ
cord-003091-uvfppirt	97	33	rejection	rejection	NN
cord-003091-uvfppirt	97	34	of	of	IN
cord-003091-uvfppirt	97	35	kidney	kidney	NN
cord-003091-uvfppirt	97	36	,	,	,
cord-003091-uvfppirt	97	37	heart	heart	NN
cord-003091-uvfppirt	97	38	,	,	,
cord-003091-uvfppirt	97	39	and	and	CC
cord-003091-uvfppirt	97	40	hand	hand	NN
cord-003091-uvfppirt	97	41	transplants	transplant	NNS
cord-003091-uvfppirt	97	42	,	,	,
cord-003091-uvfppirt	97	43	are	be	VBP
cord-003091-uvfppirt	97	44	so	so	RB
cord-003091-uvfppirt	97	45	efficient	efficient	JJ
cord-003091-uvfppirt	97	46	in	in	IN
cord-003091-uvfppirt	97	47	interfering	interfere	VBG
cord-003091-uvfppirt	97	48	with	with	IN
cord-003091-uvfppirt	97	49	T	t	NN
cord-003091-uvfppirt	97	50	cell	cell	NN
cord-003091-uvfppirt	97	51	priming	priming	NN
cord-003091-uvfppirt	97	52	or	or	CC
cord-003091-uvfppirt	97	53	T	t	NN
cord-003091-uvfppirt	97	54	cell	cell	NN
cord-003091-uvfppirt	97	55	reactivation	reactivation	NN
cord-003091-uvfppirt	97	56	(	(	-LRB-
cord-003091-uvfppirt	97	57	62	62	CD
cord-003091-uvfppirt	97	58	)	)	-RRB-
cord-003091-uvfppirt	97	59	.	.	.
cord-003091-uvfppirt	98	1	Since	since	IN
cord-003091-uvfppirt	98	2	IL-2	IL-2	NNP
cord-003091-uvfppirt	98	3	is	be	VBZ
cord-003091-uvfppirt	98	4	produced	produce	VBN
cord-003091-uvfppirt	98	5	in	in	IN
cord-003091-uvfppirt	98	6	NFATdependent	nfatdependent	NN
cord-003091-uvfppirt	98	7	manner	manner	NN
cord-003091-uvfppirt	98	8	to	to	TO
cord-003091-uvfppirt	98	9	improve	improve	VB
cord-003091-uvfppirt	98	10	the	the	DT
cord-003091-uvfppirt	98	11	adjuvanticity	adjuvanticity	NN
cord-003091-uvfppirt	98	12	of	of	IN
cord-003091-uvfppirt	98	13	PRR	PRR	NNP
cord-003091-uvfppirt	98	14	agonists	agonist	NNS
cord-003091-uvfppirt	98	15	for	for	IN
cord-003091-uvfppirt	98	16	vaccination	vaccination	NN
cord-003091-uvfppirt	98	17	purposes	purpose	NNS
cord-003091-uvfppirt	98	18	,	,	,
cord-003091-uvfppirt	98	19	the	the	DT
cord-003091-uvfppirt	98	20	capacity	capacity	NN
cord-003091-uvfppirt	98	21	of	of	IN
cord-003091-uvfppirt	98	22	selected	select	VBN
cord-003091-uvfppirt	98	23	PRR	PRR	NNP
cord-003091-uvfppirt	98	24	agonists	agonist	NNS
cord-003091-uvfppirt	98	25	to	to	TO
cord-003091-uvfppirt	98	26	induce	induce	VB
cord-003091-uvfppirt	98	27	NFAT	NFAT	NNP
cord-003091-uvfppirt	98	28	signaling	signal	VBG
cord-003091-uvfppirt	98	29	pathway	pathway	NN
cord-003091-uvfppirt	98	30	activation	activation	NN
cord-003091-uvfppirt	98	31	and	and	CC
cord-003091-uvfppirt	98	32	IL-2	il-2	NN
cord-003091-uvfppirt	98	33	production	production	NN
cord-003091-uvfppirt	98	34	should	should	MD
cord-003091-uvfppirt	98	35	be	be	VB
cord-003091-uvfppirt	98	36	considered	consider	VBN
cord-003091-uvfppirt	98	37	.	.	.
cord-003091-uvfppirt	99	1	Many	many	JJ
cord-003091-uvfppirt	99	2	PRR	PRR	NNP
cord-003091-uvfppirt	99	3	ligands	ligand	NNS
cord-003091-uvfppirt	99	4	have	have	VBP
cord-003091-uvfppirt	99	5	been	be	VBN
cord-003091-uvfppirt	99	6	shown	show	VBN
cord-003091-uvfppirt	99	7	to	to	TO
cord-003091-uvfppirt	99	8	activate	activate	VB
cord-003091-uvfppirt	99	9	the	the	DT
cord-003091-uvfppirt	99	10	NFAT	NFAT	NNP
cord-003091-uvfppirt	99	11	transcription	transcription	NN
cord-003091-uvfppirt	99	12	factor	factor	NN
cord-003091-uvfppirt	99	13	family	family	NN
cord-003091-uvfppirt	99	14	members	member	NNS
cord-003091-uvfppirt	99	15	in	in	IN
cord-003091-uvfppirt	99	16	innate	innate	JJ
cord-003091-uvfppirt	99	17	immune	immune	JJ
cord-003091-uvfppirt	99	18	cells	cell	NNS
cord-003091-uvfppirt	99	19	(	(	-LRB-
cord-003091-uvfppirt	99	20	63	63	CD
cord-003091-uvfppirt	99	21	)	)	-RRB-
cord-003091-uvfppirt	99	22	.	.	.
cord-003091-uvfppirt	100	1	The	the	DT
cord-003091-uvfppirt	100	2	NFAT	NFAT	NNP
cord-003091-uvfppirt	100	3	pathway	pathway	NN
cord-003091-uvfppirt	100	4	is	be	VBZ
cord-003091-uvfppirt	100	5	activated	activate	VBN
cord-003091-uvfppirt	100	6	in	in	IN
cord-003091-uvfppirt	100	7	neutrophils	neutrophil	NNS
cord-003091-uvfppirt	100	8	,	,	,
cord-003091-uvfppirt	100	9	macrophages	macrophage	NNS
cord-003091-uvfppirt	100	10	,	,	,
cord-003091-uvfppirt	100	11	and	and	CC
cord-003091-uvfppirt	100	12	DCs	DCs	NNP
cord-003091-uvfppirt	100	13	in	in	IN
cord-003091-uvfppirt	100	14	response	response	NN
cord-003091-uvfppirt	100	15	to	to	IN
cord-003091-uvfppirt	100	16	curdlan	curdlan	NNP
cord-003091-uvfppirt	100	17	(	(	-LRB-
cord-003091-uvfppirt	100	18	64	64	CD
cord-003091-uvfppirt	100	19	,	,	,
cord-003091-uvfppirt	100	20	65	65	CD
cord-003091-uvfppirt	100	21	)	)	-RRB-
cord-003091-uvfppirt	100	22	,	,	,
cord-003091-uvfppirt	100	23	it	-PRON-	PRP
cord-003091-uvfppirt	100	24	is	be	VBZ
cord-003091-uvfppirt	100	25	also	also	RB
cord-003091-uvfppirt	100	26	activated	activate	VBN
cord-003091-uvfppirt	100	27	in	in	IN
cord-003091-uvfppirt	100	28	DCs	DCs	NNP
cord-003091-uvfppirt	100	29	in	in	IN
cord-003091-uvfppirt	100	30	response	response	NN
cord-003091-uvfppirt	100	31	to	to	IN
cord-003091-uvfppirt	100	32	LPS	LPS	NNP
cord-003091-uvfppirt	100	33	(	(	-LRB-
cord-003091-uvfppirt	100	34	30	30	CD
cord-003091-uvfppirt	100	35	)	)	-RRB-
cord-003091-uvfppirt	100	36	downstream	downstream	NN
cord-003091-uvfppirt	100	37	of	of	IN
cord-003091-uvfppirt	100	38	CD14	CD14	NNP
cord-003091-uvfppirt	100	39	,	,	,
cord-003091-uvfppirt	100	40	it	-PRON-	PRP
cord-003091-uvfppirt	100	41	is	be	VBZ
cord-003091-uvfppirt	100	42	activated	activate	VBN
cord-003091-uvfppirt	100	43	in	in	IN
cord-003091-uvfppirt	100	44	response	response	NN
cord-003091-uvfppirt	100	45	to	to	IN
cord-003091-uvfppirt	100	46	mannose	mannose	NN
cord-003091-uvfppirt	100	47	-	-	HYPH
cord-003091-uvfppirt	100	48	capped	cap	VBN
cord-003091-uvfppirt	100	49	lipoarabinomannan	lipoarabinomannan	NNP
cord-003091-uvfppirt	101	1	(	(	-LRB-
cord-003091-uvfppirt	101	2	Man	Man	NNP
cord-003091-uvfppirt	101	3	-	-	HYPH
cord-003091-uvfppirt	101	4	LAM	LAM	NNP
cord-003091-uvfppirt	101	5	)	)	-RRB-
cord-003091-uvfppirt	101	6	,	,	,
cord-003091-uvfppirt	101	7	a	a	DT
cord-003091-uvfppirt	101	8	major	major	JJ
cord-003091-uvfppirt	101	9	lipoglican	lipoglican	NN
cord-003091-uvfppirt	101	10	of	of	IN
cord-003091-uvfppirt	101	11	Mycobacterium	Mycobacterium	NNP
cord-003091-uvfppirt	101	12	tuberculosis	tuberculosis	NN
cord-003091-uvfppirt	101	13	(	(	-LRB-
cord-003091-uvfppirt	101	14	66	66	CD
cord-003091-uvfppirt	101	15	)	)	-RRB-
cord-003091-uvfppirt	101	16	,	,	,
cord-003091-uvfppirt	101	17	and	and	CC
cord-003091-uvfppirt	101	18	downstream	downstream	NN
cord-003091-uvfppirt	101	19	of	of	IN
cord-003091-uvfppirt	101	20	TLR9	TLR9	NNP
cord-003091-uvfppirt	101	21	in	in	IN
cord-003091-uvfppirt	101	22	response	response	NN
cord-003091-uvfppirt	101	23	to	to	IN
cord-003091-uvfppirt	101	24	β	β	NN
cord-003091-uvfppirt	101	25	-	-	HYPH
cord-003091-uvfppirt	101	26	glucan	glucan	JJ
cord-003091-uvfppirt	101	27	bearing	bearing	NN
cord-003091-uvfppirt	101	28	fungi	fungus	NNS
cord-003091-uvfppirt	101	29	(	(	-LRB-
cord-003091-uvfppirt	101	30	67	67	CD
cord-003091-uvfppirt	101	31	)	)	-RRB-
cord-003091-uvfppirt	101	32	.	.	.
cord-003091-uvfppirt	102	1	The	the	DT
cord-003091-uvfppirt	102	2	production	production	NN
cord-003091-uvfppirt	102	3	of	of	IN
cord-003091-uvfppirt	102	4	IL-2	il-2	NN
cord-003091-uvfppirt	102	5	by	by	IN
cord-003091-uvfppirt	102	6	innate	innate	JJ
cord-003091-uvfppirt	102	7	immune	immune	JJ
cord-003091-uvfppirt	102	8	cells	cell	NNS
cord-003091-uvfppirt	102	9	during	during	IN
cord-003091-uvfppirt	102	10	inflammatory	inflammatory	JJ
cord-003091-uvfppirt	102	11	responses	response	NNS
cord-003091-uvfppirt	102	12	is	be	VBZ
cord-003091-uvfppirt	102	13	relevant	relevant	JJ
cord-003091-uvfppirt	102	14	not	not	RB
cord-003091-uvfppirt	102	15	only	only	RB
cord-003091-uvfppirt	102	16	for	for	IN
cord-003091-uvfppirt	102	17	an	an	DT
cord-003091-uvfppirt	102	18	efficient	efficient	JJ
cord-003091-uvfppirt	102	19	T	t	NN
cord-003091-uvfppirt	102	20	cell	cell	NN
cord-003091-uvfppirt	102	21	priming	priming	NN
cord-003091-uvfppirt	102	22	but	but	CC
cord-003091-uvfppirt	102	23	also	also	RB
cord-003091-uvfppirt	102	24	for	for	IN
cord-003091-uvfppirt	102	25	the	the	DT
cord-003091-uvfppirt	102	26	skewing	skewing	NN
cord-003091-uvfppirt	102	27	of	of	IN
cord-003091-uvfppirt	102	28	T	T	NNP
cord-003091-uvfppirt	102	29	cell	cell	NN
cord-003091-uvfppirt	102	30	activation	activation	NN
cord-003091-uvfppirt	102	31	toward	toward	IN
cord-003091-uvfppirt	102	32	type	type	NN
cord-003091-uvfppirt	102	33	I	-PRON-	PRP
cord-003091-uvfppirt	102	34	responses	response	NNS
cord-003091-uvfppirt	102	35	.	.	.
cord-003091-uvfppirt	103	1	In	in	IN
cord-003091-uvfppirt	103	2	mice	mouse	NNS
cord-003091-uvfppirt	103	3	,	,	,
cord-003091-uvfppirt	103	4	DC	DC	NNP
cord-003091-uvfppirt	103	5	-	-	HYPH
cord-003091-uvfppirt	103	6	derived	derive	VBN
cord-003091-uvfppirt	103	7	IL-2	il-2	NN
cord-003091-uvfppirt	103	8	is	be	VBZ
cord-003091-uvfppirt	103	9	one	one	CD
cord-003091-uvfppirt	103	10	of	of	IN
cord-003091-uvfppirt	103	11	the	the	DT
cord-003091-uvfppirt	103	12	cytokines	cytokine	NNS
cord-003091-uvfppirt	103	13	required	require	VBN
cord-003091-uvfppirt	103	14	to	to	TO
cord-003091-uvfppirt	103	15	elicit	elicit	VB
cord-003091-uvfppirt	103	16	IFN	IFN	NNP
cord-003091-uvfppirt	103	17	-	-	HYPH
cord-003091-uvfppirt	103	18	γ	γ	NN
cord-003091-uvfppirt	103	19	production	production	NN
cord-003091-uvfppirt	103	20	from	from	IN
cord-003091-uvfppirt	103	21	NK	NK	NNP
cord-003091-uvfppirt	103	22	cells	cell	NNS
cord-003091-uvfppirt	103	23	both	both	DT
cord-003091-uvfppirt	103	24	in	in	IN
cord-003091-uvfppirt	103	25	LPSmediated	lpsmediate	VBN
cord-003091-uvfppirt	103	26	inflammatory	inflammatory	JJ
cord-003091-uvfppirt	103	27	conditions	condition	NNS
cord-003091-uvfppirt	103	28	and	and	CC
cord-003091-uvfppirt	103	29	during	during	IN
cord-003091-uvfppirt	103	30	fungal	fungal	JJ
cord-003091-uvfppirt	103	31	infections	infection	NNS
cord-003091-uvfppirt	103	32	(	(	-LRB-
cord-003091-uvfppirt	103	33	68	68	CD
cord-003091-uvfppirt	103	34	)	)	-RRB-
cord-003091-uvfppirt	103	35	(	(	-LRB-
cord-003091-uvfppirt	103	36	69	69	CD
cord-003091-uvfppirt	103	37	)	)	-RRB-
cord-003091-uvfppirt	103	38	(	(	-LRB-
cord-003091-uvfppirt	103	39	70	70	CD
cord-003091-uvfppirt	103	40	)	)	-RRB-
cord-003091-uvfppirt	103	41	.	.	.
cord-003091-uvfppirt	104	1	IFN	IFN	NNP
cord-003091-uvfppirt	104	2	-	-	HYPH
cord-003091-uvfppirt	104	3	γ	γ	NNP
cord-003091-uvfppirt	104	4	potently	potently	RB
cord-003091-uvfppirt	104	5	activates	activate	VBZ
cord-003091-uvfppirt	104	6	macrophages	macrophage	NNS
cord-003091-uvfppirt	104	7	and	and	CC
cord-003091-uvfppirt	104	8	favors	favor	VBZ
cord-003091-uvfppirt	104	9	Th1	th1	CD
cord-003091-uvfppirt	104	10	commitment	commitment	NN
cord-003091-uvfppirt	104	11	of	of	IN
cord-003091-uvfppirt	104	12	CD4	CD4	NNP
cord-003091-uvfppirt	104	13	+	+	CC
cord-003091-uvfppirt	104	14	T	T	NNP
cord-003091-uvfppirt	104	15	cells	cell	NNS
cord-003091-uvfppirt	104	16	.	.	.
cord-003091-uvfppirt	105	1	Therefore	therefore	RB
cord-003091-uvfppirt	105	2	,	,	,
cord-003091-uvfppirt	105	3	early	early	JJ
cord-003091-uvfppirt	105	4	IFN	IFN	NNP
cord-003091-uvfppirt	105	5	-	-	HYPH
cord-003091-uvfppirt	105	6	γ	γ	NNP
cord-003091-uvfppirt	105	7	release	release	NN
cord-003091-uvfppirt	105	8	by	by	IN
cord-003091-uvfppirt	105	9	NK	NK	NNP
cord-003091-uvfppirt	105	10	cells	cell	NNS
cord-003091-uvfppirt	105	11	is	be	VBZ
cord-003091-uvfppirt	105	12	not	not	RB
cord-003091-uvfppirt	105	13	only	only	RB
cord-003091-uvfppirt	105	14	crucial	crucial	JJ
cord-003091-uvfppirt	105	15	for	for	IN
cord-003091-uvfppirt	105	16	controlling	control	VBG
cord-003091-uvfppirt	105	17	a	a	DT
cord-003091-uvfppirt	105	18	variety	variety	NN
cord-003091-uvfppirt	105	19	of	of	IN
cord-003091-uvfppirt	105	20	primary	primary	JJ
cord-003091-uvfppirt	105	21	bacterial	bacterial	JJ
cord-003091-uvfppirt	105	22	and	and	CC
cord-003091-uvfppirt	105	23	fungal	fungal	JJ
cord-003091-uvfppirt	105	24	infections	infection	NNS
cord-003091-uvfppirt	105	25	but	but	CC
cord-003091-uvfppirt	105	26	also	also	RB
cord-003091-uvfppirt	105	27	for	for	IN
cord-003091-uvfppirt	105	28	the	the	DT
cord-003091-uvfppirt	105	29	induction	induction	NN
cord-003091-uvfppirt	105	30	of	of	IN
cord-003091-uvfppirt	105	31	type	type	NN
cord-003091-uvfppirt	105	32	I	-PRON-	PRP
cord-003091-uvfppirt	105	33	immunity	immunity	NN
cord-003091-uvfppirt	105	34	and	and	CC
cord-003091-uvfppirt	105	35	memory	memory	NN
cord-003091-uvfppirt	105	36	,	,	,
cord-003091-uvfppirt	105	37	fundamental	fundamental	JJ
cord-003091-uvfppirt	105	38	for	for	IN
cord-003091-uvfppirt	105	39	the	the	DT
cord-003091-uvfppirt	105	40	protection	protection	NN
cord-003091-uvfppirt	105	41	against	against	IN
cord-003091-uvfppirt	105	42	bacterial	bacterial	JJ
cord-003091-uvfppirt	105	43	,	,	,
cord-003091-uvfppirt	105	44	fungal	fungal	JJ
cord-003091-uvfppirt	105	45	,	,	,
cord-003091-uvfppirt	105	46	and	and	CC
cord-003091-uvfppirt	105	47	viral	viral	JJ
cord-003091-uvfppirt	105	48	infections	infection	NNS
cord-003091-uvfppirt	105	49	and	and	CC
cord-003091-uvfppirt	105	50	in	in	IN
cord-003091-uvfppirt	105	51	antitumor	antitumor	JJ
cord-003091-uvfppirt	105	52	immune	immune	JJ
cord-003091-uvfppirt	105	53	therapies	therapy	NNS
cord-003091-uvfppirt	105	54	.	.	.
cord-003091-uvfppirt	106	1	Another	another	DT
cord-003091-uvfppirt	106	2	important	important	JJ
cord-003091-uvfppirt	106	3	reason	reason	NN
cord-003091-uvfppirt	106	4	for	for	IN
cord-003091-uvfppirt	106	5	considering	consider	VBG
cord-003091-uvfppirt	106	6	the	the	DT
cord-003091-uvfppirt	106	7	capacity	capacity	NN
cord-003091-uvfppirt	106	8	to	to	TO
cord-003091-uvfppirt	106	9	activate	activate	VB
cord-003091-uvfppirt	106	10	the	the	DT
cord-003091-uvfppirt	106	11	NFAT	NFAT	NNP
cord-003091-uvfppirt	106	12	pathway	pathway	NN
cord-003091-uvfppirt	106	13	in	in	IN
cord-003091-uvfppirt	106	14	adjuvant	adjuvant	NN
cord-003091-uvfppirt	106	15	selection	selection	NN
cord-003091-uvfppirt	106	16	tests	test	NNS
cord-003091-uvfppirt	106	17	is	be	VBZ
cord-003091-uvfppirt	106	18	represented	represent	VBN
cord-003091-uvfppirt	106	19	by	by	IN
cord-003091-uvfppirt	106	20	the	the	DT
cord-003091-uvfppirt	106	21	fact	fact	NN
cord-003091-uvfppirt	106	22	that	that	IN
cord-003091-uvfppirt	106	23	NFATs	NFATs	NNP
cord-003091-uvfppirt	106	24	regulate	regulate	VBP
cord-003091-uvfppirt	106	25	also	also	RB
cord-003091-uvfppirt	106	26	the	the	DT
cord-003091-uvfppirt	106	27	production	production	NN
cord-003091-uvfppirt	106	28	of	of	IN
cord-003091-uvfppirt	106	29	the	the	DT
cord-003091-uvfppirt	106	30	prostanoid	prostanoid	NNP
cord-003091-uvfppirt	106	31	PGE2	PGE2	NNP
cord-003091-uvfppirt	106	32	by	by	IN
cord-003091-uvfppirt	106	33	activated	activate	VBN
cord-003091-uvfppirt	106	34	DCs	DCs	NNP
cord-003091-uvfppirt	106	35	(	(	-LRB-
cord-003091-uvfppirt	106	36	71	71	CD
cord-003091-uvfppirt	106	37	)	)	-RRB-
cord-003091-uvfppirt	106	38	.	.	.
cord-003091-uvfppirt	107	1	PGE2	PGE2	NNP
cord-003091-uvfppirt	107	2	promotes	promote	VBZ
cord-003091-uvfppirt	107	3	activated	activate	VBN
cord-003091-uvfppirt	107	4	DC	DC	NNP
cord-003091-uvfppirt	107	5	migration	migration	NN
cord-003091-uvfppirt	107	6	(	(	-LRB-
cord-003091-uvfppirt	107	7	72	72	CD
cord-003091-uvfppirt	107	8	)	)	-RRB-
cord-003091-uvfppirt	107	9	and	and	CC
cord-003091-uvfppirt	107	10	sustains	sustain	VBZ
cord-003091-uvfppirt	107	11	vasodilation	vasodilation	NN
cord-003091-uvfppirt	107	12	and	and	CC
cord-003091-uvfppirt	107	13	local	local	JJ
cord-003091-uvfppirt	107	14	edema	edema	NN
cord-003091-uvfppirt	107	15	formation	formation	NN
cord-003091-uvfppirt	107	16	during	during	IN
cord-003091-uvfppirt	107	17	the	the	DT
cord-003091-uvfppirt	107	18	inflammatory	inflammatory	JJ
cord-003091-uvfppirt	107	19	process	process	NN
cord-003091-uvfppirt	107	20	.	.	.
cord-003091-uvfppirt	108	1	This	this	DT
cord-003091-uvfppirt	108	2	is	be	VBZ
cord-003091-uvfppirt	108	3	particularly	particularly	RB
cord-003091-uvfppirt	108	4	relevant	relevant	JJ
cord-003091-uvfppirt	108	5	for	for	IN
cord-003091-uvfppirt	108	6	vaccination	vaccination	NN
cord-003091-uvfppirt	108	7	purposes	purpose	NNS
cord-003091-uvfppirt	108	8	since	since	IN
cord-003091-uvfppirt	108	9	the	the	DT
cord-003091-uvfppirt	108	10	increase	increase	NN
cord-003091-uvfppirt	108	11	of	of	IN
cord-003091-uvfppirt	108	12	the	the	DT
cord-003091-uvfppirt	108	13	interstitial	interstitial	JJ
cord-003091-uvfppirt	108	14	pressure	pressure	NN
cord-003091-uvfppirt	108	15	generated	generate	VBN
cord-003091-uvfppirt	108	16	by	by	IN
cord-003091-uvfppirt	108	17	the	the	DT
cord-003091-uvfppirt	108	18	edema	edema	NN
cord-003091-uvfppirt	108	19	forces	force	VBZ
cord-003091-uvfppirt	108	20	the	the	DT
cord-003091-uvfppirt	108	21	fluids	fluid	NNS
cord-003091-uvfppirt	108	22	into	into	IN
cord-003091-uvfppirt	108	23	the	the	DT
cord-003091-uvfppirt	108	24	afferent	afferent	JJ
cord-003091-uvfppirt	108	25	lymphatics	lymphatic	NNS
cord-003091-uvfppirt	108	26	and	and	CC
cord-003091-uvfppirt	108	27	favors	favor	VBZ
cord-003091-uvfppirt	108	28	a	a	DT
cord-003091-uvfppirt	108	29	first	first	JJ
cord-003091-uvfppirt	108	30	wave	wave	NN
cord-003091-uvfppirt	108	31	of	of	IN
cord-003091-uvfppirt	108	32	antigen	antigen	NN
cord-003091-uvfppirt	108	33	arrival	arrival	NN
cord-003091-uvfppirt	108	34	to	to	IN
cord-003091-uvfppirt	108	35	the	the	DT
cord-003091-uvfppirt	108	36	draining	drain	VBG
cord-003091-uvfppirt	108	37	LN	ln	NN
cord-003091-uvfppirt	108	38	(	(	-LRB-
cord-003091-uvfppirt	108	39	71	71	CD
cord-003091-uvfppirt	108	40	)	)	-RRB-
cord-003091-uvfppirt	108	41	.	.	.
cord-003091-uvfppirt	109	1	Intriguingly	intriguingly	RB
cord-003091-uvfppirt	109	2	,	,	,
cord-003091-uvfppirt	109	3	LN	LN	NNP
cord-003091-uvfppirt	109	4	drainage	drainage	NN
cord-003091-uvfppirt	109	5	of	of	IN
cord-003091-uvfppirt	109	6	proteins	protein	NNS
cord-003091-uvfppirt	109	7	or	or	CC
cord-003091-uvfppirt	109	8	antigens	antigen	NNS
cord-003091-uvfppirt	109	9	occurs	occur	VBZ
cord-003091-uvfppirt	109	10	very	very	RB
cord-003091-uvfppirt	109	11	rapidly	rapidly	RB
cord-003091-uvfppirt	109	12	after	after	IN
cord-003091-uvfppirt	109	13	subcutaneous	subcutaneous	JJ
cord-003091-uvfppirt	109	14	,	,	,
cord-003091-uvfppirt	109	15	intradermal	intradermal	JJ
cord-003091-uvfppirt	109	16	,	,	,
cord-003091-uvfppirt	109	17	and	and	CC
cord-003091-uvfppirt	109	18	intramuscular	intramuscular	JJ
cord-003091-uvfppirt	109	19	immunization	immunization	NN
cord-003091-uvfppirt	109	20	(	(	-LRB-
cord-003091-uvfppirt	109	21	73	73	CD
cord-003091-uvfppirt	109	22	)	)	-RRB-
cord-003091-uvfppirt	109	23	(	(	-LRB-
cord-003091-uvfppirt	109	24	74	74	CD
cord-003091-uvfppirt	109	25	)	)	-RRB-
cord-003091-uvfppirt	109	26	(	(	-LRB-
cord-003091-uvfppirt	109	27	75	75	CD
cord-003091-uvfppirt	109	28	)	)	-RRB-
cord-003091-uvfppirt	109	29	,	,	,
cord-003091-uvfppirt	109	30	thus	thus	RB
cord-003091-uvfppirt	109	31	permitting	permit	VBG
cord-003091-uvfppirt	109	32	an	an	DT
cord-003091-uvfppirt	109	33	extremely	extremely	RB
cord-003091-uvfppirt	109	34	fast	fast	JJ
cord-003091-uvfppirt	109	35	uptake	uptake	NN
cord-003091-uvfppirt	109	36	by	by	IN
cord-003091-uvfppirt	109	37	phagocytes	phagocyte	NNS
cord-003091-uvfppirt	109	38	strategically	strategically	RB
cord-003091-uvfppirt	109	39	localized	localize	VBN
cord-003091-uvfppirt	109	40	in	in	IN
cord-003091-uvfppirt	109	41	close	close	JJ
cord-003091-uvfppirt	109	42	proximity	proximity	NN
cord-003091-uvfppirt	109	43	to	to	IN
cord-003091-uvfppirt	109	44	the	the	DT
cord-003091-uvfppirt	109	45	subcapsular	subcapsular	JJ
cord-003091-uvfppirt	109	46	sinus	sinus	NNP
cord-003091-uvfppirt	109	47	or	or	CC
cord-003091-uvfppirt	109	48	lymphatic	lymphatic	JJ
cord-003091-uvfppirt	109	49	sinus	sinus	NN
cord-003091-uvfppirt	109	50	of	of	IN
cord-003091-uvfppirt	109	51	draining	drain	VBG
cord-003091-uvfppirt	109	52	LN	ln	NN
cord-003091-uvfppirt	109	53	(	(	-LRB-
cord-003091-uvfppirt	109	54	76	76	CD
cord-003091-uvfppirt	109	55	)	)	-RRB-
cord-003091-uvfppirt	109	56	(	(	-LRB-
cord-003091-uvfppirt	109	57	77	77	CD
cord-003091-uvfppirt	109	58	)	)	-RRB-
cord-003091-uvfppirt	109	59	(	(	-LRB-
cord-003091-uvfppirt	109	60	78	78	CD
cord-003091-uvfppirt	109	61	)	)	-RRB-
cord-003091-uvfppirt	109	62	(	(	-LRB-
cord-003091-uvfppirt	109	63	79	79	CD
cord-003091-uvfppirt	109	64	)	)	-RRB-
cord-003091-uvfppirt	109	65	.	.	.
cord-003091-uvfppirt	110	1	Antigen	antigen	NN
cord-003091-uvfppirt	110	2	-	-	HYPH
cord-003091-uvfppirt	110	3	presenting	present	VBG
cord-003091-uvfppirt	110	4	cells	cell	NNS
cord-003091-uvfppirt	110	5	in	in	IN
cord-003091-uvfppirt	110	6	LN	LN	NNP
cord-003091-uvfppirt	110	7	then	then	RB
cord-003091-uvfppirt	110	8	maintain	maintain	VBP
cord-003091-uvfppirt	110	9	the	the	DT
cord-003091-uvfppirt	110	10	homeostasis	homeostasis	NN
cord-003091-uvfppirt	110	11	of	of	IN
cord-003091-uvfppirt	110	12	LN	ln	NN
cord-003091-uvfppirt	110	13	themselves	-PRON-	PRP
cord-003091-uvfppirt	110	14	and	and	CC
cord-003091-uvfppirt	110	15	activate	activate	VB
cord-003091-uvfppirt	110	16	adaptive	adaptive	JJ
cord-003091-uvfppirt	110	17	immune	immune	JJ
cord-003091-uvfppirt	110	18	responses	response	NNS
cord-003091-uvfppirt	110	19	.	.	.
cord-003091-uvfppirt	111	1	In	in	IN
cord-003091-uvfppirt	111	2	the	the	DT
cord-003091-uvfppirt	111	3	last	last	JJ
cord-003091-uvfppirt	111	4	decades	decade	NNS
cord-003091-uvfppirt	111	5	,	,	,
cord-003091-uvfppirt	111	6	the	the	DT
cord-003091-uvfppirt	111	7	long	long	RB
cord-003091-uvfppirt	111	8	-	-	HYPH
cord-003091-uvfppirt	111	9	held	hold	VBN
cord-003091-uvfppirt	111	10	paradigm	paradigm	NN
cord-003091-uvfppirt	111	11	of	of	IN
cord-003091-uvfppirt	111	12	migratory	migratory	JJ
cord-003091-uvfppirt	111	13	DCs	DCs	NNP
cord-003091-uvfppirt	111	14	,	,	,
cord-003091-uvfppirt	111	15	resident	resident	NN
cord-003091-uvfppirt	111	16	in	in	IN
cord-003091-uvfppirt	111	17	peripheral	peripheral	JJ
cord-003091-uvfppirt	111	18	tissues	tissue	NNS
cord-003091-uvfppirt	111	19	as	as	IN
cord-003091-uvfppirt	111	20	the	the	DT
cord-003091-uvfppirt	111	21	skin	skin	NN
cord-003091-uvfppirt	111	22	,	,	,
cord-003091-uvfppirt	111	23	as	as	IN
cord-003091-uvfppirt	111	24	unique	unique	JJ
cord-003091-uvfppirt	111	25	APCs	apc	NNS
cord-003091-uvfppirt	111	26	involved	involve	VBN
cord-003091-uvfppirt	111	27	in	in	IN
cord-003091-uvfppirt	111	28	T	t	NN
cord-003091-uvfppirt	111	29	cell	cell	NN
cord-003091-uvfppirt	111	30	immunity	immunity	NN
cord-003091-uvfppirt	111	31	has	have	VBZ
cord-003091-uvfppirt	111	32	dramatically	dramatically	RB
cord-003091-uvfppirt	111	33	changed	change	VBN
cord-003091-uvfppirt	111	34	.	.	.
cord-003091-uvfppirt	112	1	Indeed	indeed	RB
cord-003091-uvfppirt	112	2	,	,	,
cord-003091-uvfppirt	112	3	CD169	CD169	NNP
cord-003091-uvfppirt	112	4	+	+	CC
cord-003091-uvfppirt	112	5	subcapsular	subcapsular	JJ
cord-003091-uvfppirt	112	6	sinus	sinus	NNP
cord-003091-uvfppirt	112	7	macrophages	macrophage	NNS
cord-003091-uvfppirt	112	8	,	,	,
cord-003091-uvfppirt	112	9	medullary	medullary	JJ
cord-003091-uvfppirt	112	10	macrophages	macrophage	NNS
cord-003091-uvfppirt	112	11	,	,	,
cord-003091-uvfppirt	112	12	and	and	CC
cord-003091-uvfppirt	112	13	LN	ln	NN
cord-003091-uvfppirt	112	14	-	-	HYPH
cord-003091-uvfppirt	112	15	resident	resident	JJ
cord-003091-uvfppirt	112	16	DCs	dc	NNS
cord-003091-uvfppirt	112	17	are	be	VBP
cord-003091-uvfppirt	112	18	LN	LN	NNP
cord-003091-uvfppirt	112	19	sentinels	sentinel	NNS
cord-003091-uvfppirt	112	20	that	that	WDT
cord-003091-uvfppirt	112	21	avoid	avoid	VBP
cord-003091-uvfppirt	112	22	excessive	excessive	JJ
cord-003091-uvfppirt	112	23	pathogen	pathogen	NN
cord-003091-uvfppirt	112	24	dissemination	dissemination	NN
cord-003091-uvfppirt	112	25	(	(	-LRB-
cord-003091-uvfppirt	112	26	80	80	CD
cord-003091-uvfppirt	112	27	,	,	,
cord-003091-uvfppirt	112	28	81	81	CD
cord-003091-uvfppirt	112	29	)	)	-RRB-
cord-003091-uvfppirt	112	30	and	and	CC
cord-003091-uvfppirt	112	31	mediators	mediator	NNS
cord-003091-uvfppirt	112	32	of	of	IN
cord-003091-uvfppirt	112	33	immune	immune	JJ
cord-003091-uvfppirt	112	34	responses	response	NNS
cord-003091-uvfppirt	112	35	(	(	-LRB-
cord-003091-uvfppirt	112	36	76	76	CD
cord-003091-uvfppirt	112	37	)	)	-RRB-
cord-003091-uvfppirt	112	38	.	.	.
cord-003091-uvfppirt	113	1	Concerning	concern	VBG
cord-003091-uvfppirt	113	2	migratory	migratory	JJ
cord-003091-uvfppirt	113	3	DCs	dc	NNS
cord-003091-uvfppirt	113	4	and	and	CC
cord-003091-uvfppirt	113	5	considering	consider	VBG
cord-003091-uvfppirt	113	6	the	the	DT
cord-003091-uvfppirt	113	7	skin	skin	NN
cord-003091-uvfppirt	113	8	,	,	,
cord-003091-uvfppirt	113	9	which	which	WDT
cord-003091-uvfppirt	113	10	represents	represent	VBZ
cord-003091-uvfppirt	113	11	the	the	DT
cord-003091-uvfppirt	113	12	site	site	NN
cord-003091-uvfppirt	113	13	of	of	IN
cord-003091-uvfppirt	113	14	utmost	utmost	JJ
cord-003091-uvfppirt	113	15	importance	importance	NN
cord-003091-uvfppirt	113	16	for	for	IN
cord-003091-uvfppirt	113	17	vaccination	vaccination	NN
cord-003091-uvfppirt	113	18	strategies	strategy	NNS
cord-003091-uvfppirt	113	19	due	due	JJ
cord-003091-uvfppirt	113	20	to	to	IN
cord-003091-uvfppirt	113	21	the	the	DT
cord-003091-uvfppirt	113	22	ease	ease	NN
cord-003091-uvfppirt	113	23	accessibility	accessibility	NN
cord-003091-uvfppirt	113	24	and	and	CC
cord-003091-uvfppirt	113	25	the	the	DT
cord-003091-uvfppirt	113	26	extremely	extremely	RB
cord-003091-uvfppirt	113	27	high	high	JJ
cord-003091-uvfppirt	113	28	presence	presence	NN
cord-003091-uvfppirt	113	29	of	of	IN
cord-003091-uvfppirt	113	30	DCs	DCs	NNP
cord-003091-uvfppirt	113	31	,	,	,
cord-003091-uvfppirt	113	32	skin	skin	NN
cord-003091-uvfppirt	113	33	-	-	HYPH
cord-003091-uvfppirt	113	34	resident	resident	JJ
cord-003091-uvfppirt	113	35	DCs	dc	NNS
cord-003091-uvfppirt	113	36	have	have	VBP
cord-003091-uvfppirt	113	37	been	be	VBN
cord-003091-uvfppirt	113	38	subdivided	subdivide	VBN
cord-003091-uvfppirt	113	39	into	into	IN
cord-003091-uvfppirt	113	40	epidermalresident	epidermalresident	NN
cord-003091-uvfppirt	113	41	Langerhans	Langerhans	NNP
cord-003091-uvfppirt	113	42	cells	cell	NNS
cord-003091-uvfppirt	113	43	(	(	-LRB-
cord-003091-uvfppirt	113	44	LCs	LCs	NNP
cord-003091-uvfppirt	113	45	)	)	-RRB-
cord-003091-uvfppirt	113	46	,	,	,
cord-003091-uvfppirt	113	47	which	which	WDT
cord-003091-uvfppirt	113	48	are	be	VBP
cord-003091-uvfppirt	113	49	Langerin	Langerin	NNP
cord-003091-uvfppirt	113	50	+	+	CC
cord-003091-uvfppirt	113	51	and	and	CC
cord-003091-uvfppirt	113	52	two	two	CD
cord-003091-uvfppirt	113	53	diverse	diverse	JJ
cord-003091-uvfppirt	113	54	subsets	subset	NNS
cord-003091-uvfppirt	113	55	of	of	IN
cord-003091-uvfppirt	113	56	dermal	dermal	JJ
cord-003091-uvfppirt	113	57	(	(	-LRB-
cord-003091-uvfppirt	113	58	d)DCs	d)dcs	NN
cord-003091-uvfppirt	113	59	:	:	:
cord-003091-uvfppirt	113	60	Langerin	Langerin	NNP
cord-003091-uvfppirt	113	61	+	+	CC
cord-003091-uvfppirt	113	62	CD103	cd103	NN
cord-003091-uvfppirt	113	63	+	+	CC
cord-003091-uvfppirt	113	64	and	and	CC
cord-003091-uvfppirt	113	65	Langerin	Langerin	NNP
cord-003091-uvfppirt	113	66	−	−	NNP
cord-003091-uvfppirt	113	67	CD103	CD103	NNP
cord-003091-uvfppirt	113	68	−	−	NNP
cord-003091-uvfppirt	113	69	(	(	-LRB-
cord-003091-uvfppirt	113	70	14	14	CD
cord-003091-uvfppirt	113	71	,	,	,
cord-003091-uvfppirt	113	72	82	82	CD
cord-003091-uvfppirt	113	73	)	)	-RRB-
cord-003091-uvfppirt	113	74	.	.	.
cord-003091-uvfppirt	114	1	Upon	upon	IN
cord-003091-uvfppirt	114	2	infection	infection	NN
cord-003091-uvfppirt	114	3	,	,	,
cord-003091-uvfppirt	114	4	dDCs	ddc	NNS
cord-003091-uvfppirt	114	5	migrate	migrate	VBP
cord-003091-uvfppirt	114	6	to	to	IN
cord-003091-uvfppirt	114	7	the	the	DT
cord-003091-uvfppirt	114	8	LN	ln	NN
cord-003091-uvfppirt	114	9	within	within	IN
cord-003091-uvfppirt	114	10	10	10	CD
cord-003091-uvfppirt	114	11	-	-	SYM
cord-003091-uvfppirt	114	12	24	24	CD
cord-003091-uvfppirt	114	13	h	h	NN
cord-003091-uvfppirt	114	14	while	while	IN
cord-003091-uvfppirt	114	15	LCs	LCs	NNP
cord-003091-uvfppirt	114	16	within	within	IN
cord-003091-uvfppirt	114	17	48	48	CD
cord-003091-uvfppirt	114	18	-	-	SYM
cord-003091-uvfppirt	114	19	72	72	CD
cord-003091-uvfppirt	114	20	h	h	NN
cord-003091-uvfppirt	114	21	,	,	,
cord-003091-uvfppirt	114	22	supporting	support	VBG
cord-003091-uvfppirt	114	23	long	long	RB
cord-003091-uvfppirt	114	24	-	-	HYPH
cord-003091-uvfppirt	114	25	lasting	last	VBG
cord-003091-uvfppirt	114	26	ag	ag	NN
cord-003091-uvfppirt	114	27	-	-	HYPH
cord-003091-uvfppirt	114	28	presentation	presentation	NN
cord-003091-uvfppirt	114	29	.	.	.
cord-003091-uvfppirt	115	1	Several	several	JJ
cord-003091-uvfppirt	115	2	works	work	NNS
cord-003091-uvfppirt	115	3	reveal	reveal	VBP
cord-003091-uvfppirt	115	4	the	the	DT
cord-003091-uvfppirt	115	5	intrinsic	intrinsic	JJ
cord-003091-uvfppirt	115	6	differences	difference	NNS
cord-003091-uvfppirt	115	7	between	between	IN
cord-003091-uvfppirt	115	8	the	the	DT
cord-003091-uvfppirt	115	9	two	two	CD
cord-003091-uvfppirt	115	10	subsets	subset	NNS
cord-003091-uvfppirt	115	11	in	in	IN
cord-003091-uvfppirt	115	12	inducing	induce	VBG
cord-003091-uvfppirt	115	13	Th	Th	NNP
cord-003091-uvfppirt	115	14	or	or	CC
cord-003091-uvfppirt	115	15	CTL	CTL	NNP
cord-003091-uvfppirt	115	16	responses	response	NNS
cord-003091-uvfppirt	115	17	,	,	,
cord-003091-uvfppirt	115	18	due	due	IN
cord-003091-uvfppirt	115	19	to	to	IN
cord-003091-uvfppirt	115	20	the	the	DT
cord-003091-uvfppirt	115	21	particular	particular	JJ
cord-003091-uvfppirt	115	22	cross	cross	NN
cord-003091-uvfppirt	115	23	-	-	JJ
cord-003091-uvfppirt	115	24	presenting	presenting	JJ
cord-003091-uvfppirt	115	25	capabilities	capability	NNS
cord-003091-uvfppirt	115	26	of	of	IN
cord-003091-uvfppirt	115	27	CD103	CD103	NNP
cord-003091-uvfppirt	115	28	+	+	CC
cord-003091-uvfppirt	115	29	dDCs	dDCs	NNP
cord-003091-uvfppirt	115	30	,	,	,
cord-003091-uvfppirt	115	31	for	for	IN
cord-003091-uvfppirt	115	32	instance	instance	NN
cord-003091-uvfppirt	115	33	(	(	-LRB-
cord-003091-uvfppirt	115	34	19	19	CD
cord-003091-uvfppirt	115	35	,	,	,
cord-003091-uvfppirt	115	36	20	20	CD
cord-003091-uvfppirt	115	37	,	,	,
cord-003091-uvfppirt	115	38	83	83	CD
cord-003091-uvfppirt	115	39	)	)	-RRB-
cord-003091-uvfppirt	115	40	.	.	.
cord-003091-uvfppirt	116	1	Once	once	RB
cord-003091-uvfppirt	116	2	in	in	IN
cord-003091-uvfppirt	116	3	the	the	DT
cord-003091-uvfppirt	116	4	LN	ln	NN
cord-003091-uvfppirt	116	5	,	,	,
cord-003091-uvfppirt	116	6	whose	whose	WP$
cord-003091-uvfppirt	116	7	strategical	strategical	JJ
cord-003091-uvfppirt	116	8	architecture	architecture	NN
cord-003091-uvfppirt	116	9	enhances	enhance	VBZ
cord-003091-uvfppirt	116	10	the	the	DT
cord-003091-uvfppirt	116	11	probability	probability	NN
cord-003091-uvfppirt	116	12	of	of	IN
cord-003091-uvfppirt	116	13	encounter	encounter	NN
cord-003091-uvfppirt	116	14	between	between	IN
cord-003091-uvfppirt	116	15	migratory	migratory	JJ
cord-003091-uvfppirt	116	16	DCs	DCs	NNP
cord-003091-uvfppirt	116	17	and	and	CC
cord-003091-uvfppirt	116	18	cognate	cognate	JJ
cord-003091-uvfppirt	116	19	naïve	naïve	JJ
cord-003091-uvfppirt	116	20	T	t	NN
cord-003091-uvfppirt	116	21	cell	cell	NN
cord-003091-uvfppirt	116	22	,	,	,
cord-003091-uvfppirt	116	23	adaptive	adaptive	JJ
cord-003091-uvfppirt	116	24	immunity	immunity	NN
cord-003091-uvfppirt	116	25	is	be	VBZ
cord-003091-uvfppirt	116	26	initiated	initiate	VBN
cord-003091-uvfppirt	116	27	.	.	.
cord-003091-uvfppirt	117	1	Of	of	IN
cord-003091-uvfppirt	117	2	note	note	NN
cord-003091-uvfppirt	117	3	,	,	,
cord-003091-uvfppirt	117	4	LN	ln	NN
cord-003091-uvfppirt	117	5	-	-	HYPH
cord-003091-uvfppirt	117	6	resident	resident	JJ
cord-003091-uvfppirt	117	7	DCs	dc	NNS
cord-003091-uvfppirt	117	8	are	be	VBP
cord-003091-uvfppirt	117	9	sufficient	sufficient	JJ
cord-003091-uvfppirt	117	10	to	to	TO
cord-003091-uvfppirt	117	11	promote	promote	VB
cord-003091-uvfppirt	117	12	early	early	JJ
cord-003091-uvfppirt	117	13	adaptive	adaptive	JJ
cord-003091-uvfppirt	117	14	responses	response	NNS
cord-003091-uvfppirt	117	15	independently	independently	RB
cord-003091-uvfppirt	117	16	of	of	IN
cord-003091-uvfppirt	117	17	migratory	migratory	JJ
cord-003091-uvfppirt	117	18	DCs	dc	NNS
cord-003091-uvfppirt	117	19	when	when	WRB
cord-003091-uvfppirt	117	20	pathogens	pathogen	NNS
cord-003091-uvfppirt	117	21	or	or	CC
cord-003091-uvfppirt	117	22	antigens	antigen	NNS
cord-003091-uvfppirt	117	23	directly	directly	RB
cord-003091-uvfppirt	117	24	access	access	VBP
cord-003091-uvfppirt	117	25	the	the	DT
cord-003091-uvfppirt	117	26	lymphatic	lymphatic	JJ
cord-003091-uvfppirt	117	27	conduits	conduit	NNS
cord-003091-uvfppirt	117	28	(	(	-LRB-
cord-003091-uvfppirt	117	29	76	76	CD
cord-003091-uvfppirt	117	30	,	,	,
cord-003091-uvfppirt	117	31	84	84	CD
cord-003091-uvfppirt	117	32	,	,	,
cord-003091-uvfppirt	117	33	85	85	CD
cord-003091-uvfppirt	117	34	)	)	-RRB-
cord-003091-uvfppirt	117	35	.	.	.
cord-003091-uvfppirt	118	1	In	in	IN
cord-003091-uvfppirt	118	2	antiviral	antiviral	JJ
cord-003091-uvfppirt	118	3	responses	response	NNS
cord-003091-uvfppirt	118	4	,	,	,
cord-003091-uvfppirt	118	5	CD8α	CD8α	NNP
cord-003091-uvfppirt	118	6	+	+	CC
cord-003091-uvfppirt	118	7	LN	ln	NN
cord-003091-uvfppirt	118	8	-	-	HYPH
cord-003091-uvfppirt	118	9	resident	resident	JJ
cord-003091-uvfppirt	118	10	DCs	dc	NNS
cord-003091-uvfppirt	118	11	play	play	VBP
cord-003091-uvfppirt	118	12	a	a	DT
cord-003091-uvfppirt	118	13	crucial	crucial	JJ
cord-003091-uvfppirt	118	14	role	role	NN
cord-003091-uvfppirt	118	15	,	,	,
cord-003091-uvfppirt	118	16	thanks	thank	NNS
cord-003091-uvfppirt	118	17	to	to	IN
cord-003091-uvfppirt	118	18	their	-PRON-	PRP$
cord-003091-uvfppirt	118	19	intrinsic	intrinsic	JJ
cord-003091-uvfppirt	118	20	capability	capability	NN
cord-003091-uvfppirt	118	21	of	of	IN
cord-003091-uvfppirt	118	22	cross	cross	NN
cord-003091-uvfppirt	118	23	-	-	NN
cord-003091-uvfppirt	118	24	presentation	presentation	NN
cord-003091-uvfppirt	118	25	to	to	IN
cord-003091-uvfppirt	118	26	CD8	CD8	NNP
cord-003091-uvfppirt	118	27	+	+	SYM
cord-003091-uvfppirt	118	28	CTL	CTL	NNP
cord-003091-uvfppirt	118	29	(	(	-LRB-
cord-003091-uvfppirt	118	30	86	86	CD
cord-003091-uvfppirt	118	31	,	,	,
cord-003091-uvfppirt	118	32	87	87	CD
cord-003091-uvfppirt	118	33	)	)	-RRB-
cord-003091-uvfppirt	118	34	that	that	WDT
cord-003091-uvfppirt	118	35	may	may	MD
cord-003091-uvfppirt	118	36	be	be	VB
cord-003091-uvfppirt	118	37	supported	support	VBN
cord-003091-uvfppirt	118	38	by	by	IN
cord-003091-uvfppirt	118	39	pDCs	pDCs	NNP
cord-003091-uvfppirt	118	40	(	(	-LRB-
cord-003091-uvfppirt	118	41	88	88	CD
cord-003091-uvfppirt	118	42	)	)	-RRB-
cord-003091-uvfppirt	118	43	.	.	.
cord-003091-uvfppirt	119	1	In	in	IN
cord-003091-uvfppirt	119	2	Herpes	Herpes	NNP
cord-003091-uvfppirt	119	3	Simplex	Simplex	NNP
cord-003091-uvfppirt	119	4	Virus	Virus	NNP
cord-003091-uvfppirt	119	5	(	(	-LRB-
cord-003091-uvfppirt	119	6	HSV	HSV	NNP
cord-003091-uvfppirt	119	7	)	)	-RRB-
cord-003091-uvfppirt	119	8	skin	skin	NN
cord-003091-uvfppirt	119	9	infection	infection	NN
cord-003091-uvfppirt	119	10	,	,	,
cord-003091-uvfppirt	119	11	CD8α	CD8α	NNP
cord-003091-uvfppirt	119	12	+	+	CC
cord-003091-uvfppirt	119	13	LN	ln	NN
cord-003091-uvfppirt	119	14	-	-	HYPH
cord-003091-uvfppirt	119	15	resident	resident	JJ
cord-003091-uvfppirt	119	16	DCs	DCs	NNP
cord-003091-uvfppirt	119	17	uptake	uptake	NN
cord-003091-uvfppirt	119	18	cargo	cargo	NN
cord-003091-uvfppirt	119	19	-	-	HYPH
cord-003091-uvfppirt	119	20	antigens	antigen	NNS
cord-003091-uvfppirt	119	21	,	,	,
cord-003091-uvfppirt	119	22	ferried	ferry	VBN
cord-003091-uvfppirt	119	23	by	by	IN
cord-003091-uvfppirt	119	24	skinresident	skinresident	JJ
cord-003091-uvfppirt	119	25	migratory	migratory	JJ
cord-003091-uvfppirt	119	26	DCs	DCs	NNP
cord-003091-uvfppirt	119	27	in	in	IN
cord-003091-uvfppirt	119	28	order	order	NN
cord-003091-uvfppirt	119	29	to	to	TO
cord-003091-uvfppirt	119	30	elicit	elicit	VB
cord-003091-uvfppirt	119	31	CTL	CTL	NNP
cord-003091-uvfppirt	119	32	(	(	-LRB-
cord-003091-uvfppirt	119	33	89	89	CD
cord-003091-uvfppirt	119	34	)	)	-RRB-
cord-003091-uvfppirt	119	35	.	.	.
cord-003091-uvfppirt	120	1	Indeed	indeed	RB
cord-003091-uvfppirt	120	2	,	,	,
cord-003091-uvfppirt	120	3	LCs	LCs	NNP
cord-003091-uvfppirt	120	4	and	and	CC
cord-003091-uvfppirt	120	5	dDCs	dDCs	NNP
cord-003091-uvfppirt	120	6	synergize	synergize	VBP
cord-003091-uvfppirt	120	7	with	with	IN
cord-003091-uvfppirt	120	8	CD8α	CD8α	NNP
cord-003091-uvfppirt	120	9	+	+	CC
cord-003091-uvfppirt	120	10	LN	ln	NN
cord-003091-uvfppirt	120	11	-	-	HYPH
cord-003091-uvfppirt	120	12	resident	resident	JJ
cord-003091-uvfppirt	120	13	DCs	dc	NNS
cord-003091-uvfppirt	120	14	,	,	,
cord-003091-uvfppirt	120	15	which	which	WDT
cord-003091-uvfppirt	120	16	stand	stand	VBP
cord-003091-uvfppirt	120	17	out	out	RP
cord-003091-uvfppirt	120	18	as	as	IN
cord-003091-uvfppirt	120	19	the	the	DT
cord-003091-uvfppirt	120	20	most	most	RBS
cord-003091-uvfppirt	120	21	potent	potent	JJ
cord-003091-uvfppirt	120	22	CTL	CTL	NNP
cord-003091-uvfppirt	120	23	inducers	inducer	NNS
cord-003091-uvfppirt	120	24	,	,	,
cord-003091-uvfppirt	120	25	preferentially	preferentially	RB
cord-003091-uvfppirt	120	26	sustaining	sustain	VBG
cord-003091-uvfppirt	120	27	CD4	CD4	NNP
cord-003091-uvfppirt	121	1	+	+	CC
cord-003091-uvfppirt	122	1	Th	th	DT
cord-003091-uvfppirt	122	2	responses	response	NNS
cord-003091-uvfppirt	122	3	both	both	DT
cord-003091-uvfppirt	122	4	in	in	IN
cord-003091-uvfppirt	122	5	influenza	influenza	NN
cord-003091-uvfppirt	122	6	(	(	-LRB-
cord-003091-uvfppirt	122	7	90	90	CD
cord-003091-uvfppirt	122	8	)	)	-RRB-
cord-003091-uvfppirt	122	9	and	and	CC
cord-003091-uvfppirt	122	10	HSV	HSV	NNP
cord-003091-uvfppirt	122	11	cutaneous	cutaneous	JJ
cord-003091-uvfppirt	122	12	infections	infection	NNS
cord-003091-uvfppirt	122	13	(	(	-LRB-
cord-003091-uvfppirt	122	14	91	91	CD
cord-003091-uvfppirt	122	15	)	)	-RRB-
cord-003091-uvfppirt	122	16	.	.	.
cord-003091-uvfppirt	123	1	In	in	IN
cord-003091-uvfppirt	123	2	addition	addition	NN
cord-003091-uvfppirt	123	3	to	to	IN
cord-003091-uvfppirt	123	4	CD8α	CD8α	NNP
cord-003091-uvfppirt	123	5	+	+	CC
cord-003091-uvfppirt	123	6	LN	ln	NN
cord-003091-uvfppirt	123	7	-	-	HYPH
cord-003091-uvfppirt	123	8	resident	resident	JJ
cord-003091-uvfppirt	123	9	DCs	DCs	NNP
cord-003091-uvfppirt	123	10	,	,	,
cord-003091-uvfppirt	123	11	CD103	CD103	NNP
cord-003091-uvfppirt	123	12	+	+	CC
cord-003091-uvfppirt	124	1	dDCs	dDCs	NNP
cord-003091-uvfppirt	124	2	display	display	VBP
cord-003091-uvfppirt	124	3	intrinsic	intrinsic	JJ
cord-003091-uvfppirt	124	4	capability	capability	NN
cord-003091-uvfppirt	124	5	of	of	IN
cord-003091-uvfppirt	124	6	cross	cross	NN
cord-003091-uvfppirt	124	7	-	-	NN
cord-003091-uvfppirt	124	8	presentation	presentation	NN
cord-003091-uvfppirt	124	9	,	,	,
cord-003091-uvfppirt	124	10	as	as	IN
cord-003091-uvfppirt	124	11	their	-PRON-	PRP$
cord-003091-uvfppirt	124	12	human	human	JJ
cord-003091-uvfppirt	124	13	counterpart	counterpart	NN
cord-003091-uvfppirt	124	14	,	,	,
cord-003091-uvfppirt	124	15	CLEC9A	CLEC9A	NNP
cord-003091-uvfppirt	124	16	+	+	CC
cord-003091-uvfppirt	124	17	CD141	cd141	NN
cord-003091-uvfppirt	124	18	+	+	CC
cord-003091-uvfppirt	124	19	DCs	DCs	NNP
cord-003091-uvfppirt	124	20	(	(	-LRB-
cord-003091-uvfppirt	124	21	92	92	CD
cord-003091-uvfppirt	124	22	)	)	-RRB-
cord-003091-uvfppirt	124	23	(	(	-LRB-
cord-003091-uvfppirt	124	24	93	93	CD
cord-003091-uvfppirt	124	25	)	)	-RRB-
cord-003091-uvfppirt	124	26	(	(	-LRB-
cord-003091-uvfppirt	124	27	94	94	CD
cord-003091-uvfppirt	124	28	)	)	-RRB-
cord-003091-uvfppirt	124	29	(	(	-LRB-
cord-003091-uvfppirt	124	30	95	95	CD
cord-003091-uvfppirt	124	31	)	)	-RRB-
cord-003091-uvfppirt	124	32	(	(	-LRB-
cord-003091-uvfppirt	124	33	96	96	CD
cord-003091-uvfppirt	124	34	)	)	-RRB-
cord-003091-uvfppirt	124	35	.	.	.
cord-003091-uvfppirt	125	1	Besides	besides	RB
cord-003091-uvfppirt	125	2	,	,	,
cord-003091-uvfppirt	125	3	some	some	DT
cord-003091-uvfppirt	125	4	authors	author	NNS
cord-003091-uvfppirt	125	5	demonstrated	demonstrate	VBD
cord-003091-uvfppirt	125	6	that	that	IN
cord-003091-uvfppirt	125	7	blocking	block	VBG
cord-003091-uvfppirt	125	8	DC	DC	NNP
cord-003091-uvfppirt	125	9	migration	migration	NN
cord-003091-uvfppirt	125	10	from	from	IN
cord-003091-uvfppirt	125	11	the	the	DT
cord-003091-uvfppirt	125	12	skin	skin	NN
cord-003091-uvfppirt	125	13	hinders	hinder	VBZ
cord-003091-uvfppirt	125	14	CD4	CD4	NNP
cord-003091-uvfppirt	125	15	+	+	CC
cord-003091-uvfppirt	125	16	T	T	NNP
cord-003091-uvfppirt	125	17	cell	cell	NN
cord-003091-uvfppirt	125	18	activation	activation	NN
cord-003091-uvfppirt	125	19	in	in	IN
cord-003091-uvfppirt	125	20	response	response	NN
cord-003091-uvfppirt	125	21	to	to	IN
cord-003091-uvfppirt	125	22	subcutaneous	subcutaneous	JJ
cord-003091-uvfppirt	125	23	bacterial	bacterial	NN
cord-003091-uvfppirt	125	24	(	(	-LRB-
cord-003091-uvfppirt	125	25	97	97	CD
cord-003091-uvfppirt	125	26	)	)	-RRB-
cord-003091-uvfppirt	125	27	or	or	CC
cord-003091-uvfppirt	125	28	soluble	soluble	JJ
cord-003091-uvfppirt	125	29	antigen	antigen	NN
cord-003091-uvfppirt	125	30	challenge	challenge	NN
cord-003091-uvfppirt	125	31	(	(	-LRB-
cord-003091-uvfppirt	125	32	98	98	CD
cord-003091-uvfppirt	125	33	)	)	-RRB-
cord-003091-uvfppirt	125	34	.	.	.
cord-003091-uvfppirt	126	1	Ablating	Ablating	NNP
cord-003091-uvfppirt	126	2	Langerin	Langerin	NNP
cord-003091-uvfppirt	127	1	+	+	CC
cord-003091-uvfppirt	127	2	dDCs	dDCs	NNP
cord-003091-uvfppirt	127	3	reduced	reduce	VBD
cord-003091-uvfppirt	127	4	T	t	NN
cord-003091-uvfppirt	127	5	cell	cell	NN
cord-003091-uvfppirt	127	6	immunity	immunity	NN
cord-003091-uvfppirt	127	7	strength	strength	NN
cord-003091-uvfppirt	127	8	,	,	,
cord-003091-uvfppirt	127	9	corroborating	corroborate	VBG
cord-003091-uvfppirt	127	10	the	the	DT
cord-003091-uvfppirt	127	11	notion	notion	NN
cord-003091-uvfppirt	127	12	that	that	IN
cord-003091-uvfppirt	127	13	migratory	migratory	JJ
cord-003091-uvfppirt	127	14	DC	DC	NNP
cord-003091-uvfppirt	127	15	complement	complement	NN
cord-003091-uvfppirt	127	16	LN	ln	NN
cord-003091-uvfppirt	127	17	-	-	HYPH
cord-003091-uvfppirt	127	18	resident	resident	NN
cord-003091-uvfppirt	127	19	DC	DC	NNP
cord-003091-uvfppirt	127	20	effects	effect	NNS
cord-003091-uvfppirt	127	21	on	on	IN
cord-003091-uvfppirt	127	22	adaptive	adaptive	JJ
cord-003091-uvfppirt	127	23	responses	response	NNS
cord-003091-uvfppirt	127	24	(	(	-LRB-
cord-003091-uvfppirt	127	25	99	99	CD
cord-003091-uvfppirt	127	26	)	)	-RRB-
cord-003091-uvfppirt	127	27	(	(	-LRB-
cord-003091-uvfppirt	127	28	100	100	CD
cord-003091-uvfppirt	127	29	)	)	-RRB-
cord-003091-uvfppirt	127	30	(	(	-LRB-
cord-003091-uvfppirt	127	31	101	101	CD
cord-003091-uvfppirt	127	32	)	)	-RRB-
cord-003091-uvfppirt	127	33	.	.	.
cord-003091-uvfppirt	128	1	Nonetheless	nonetheless	RB
cord-003091-uvfppirt	128	2	,	,	,
cord-003091-uvfppirt	128	3	the	the	DT
cord-003091-uvfppirt	128	4	roles	role	NNS
cord-003091-uvfppirt	128	5	of	of	IN
cord-003091-uvfppirt	128	6	LCs	LCs	NNP
cord-003091-uvfppirt	128	7	in	in	IN
cord-003091-uvfppirt	128	8	activating	activate	VBG
cord-003091-uvfppirt	128	9	T	T	NNP
cord-003091-uvfppirt	128	10	cells	cell	NNS
cord-003091-uvfppirt	128	11	are	be	VBP
cord-003091-uvfppirt	128	12	still	still	RB
cord-003091-uvfppirt	128	13	uncertain	uncertain	JJ
cord-003091-uvfppirt	128	14	,	,	,
cord-003091-uvfppirt	128	15	probably	probably	RB
cord-003091-uvfppirt	128	16	due	due	IN
cord-003091-uvfppirt	128	17	to	to	IN
cord-003091-uvfppirt	128	18	the	the	DT
cord-003091-uvfppirt	128	19	controversial	controversial	JJ
cord-003091-uvfppirt	128	20	functional	functional	JJ
cord-003091-uvfppirt	128	21	properties	property	NNS
cord-003091-uvfppirt	128	22	of	of	IN
cord-003091-uvfppirt	128	23	this	this	DT
cord-003091-uvfppirt	128	24	innate	innate	JJ
cord-003091-uvfppirt	128	25	subset	subset	JJ
cord-003091-uvfppirt	128	26	(	(	-LRB-
cord-003091-uvfppirt	128	27	102	102	CD
cord-003091-uvfppirt	128	28	)	)	-RRB-
cord-003091-uvfppirt	128	29	(	(	-LRB-
cord-003091-uvfppirt	128	30	103	103	CD
cord-003091-uvfppirt	128	31	)	)	-RRB-
cord-003091-uvfppirt	128	32	(	(	-LRB-
cord-003091-uvfppirt	128	33	104	104	CD
cord-003091-uvfppirt	128	34	)	)	-RRB-
cord-003091-uvfppirt	128	35	.	.	.
cord-003091-uvfppirt	129	1	Despite	despite	IN
cord-003091-uvfppirt	129	2	this	this	DT
cord-003091-uvfppirt	129	3	,	,	,
cord-003091-uvfppirt	129	4	the	the	DT
cord-003091-uvfppirt	129	5	synergic	synergic	JJ
cord-003091-uvfppirt	129	6	effects	effect	NNS
cord-003091-uvfppirt	129	7	of	of	IN
cord-003091-uvfppirt	129	8	LN	ln	NN
cord-003091-uvfppirt	129	9	resident	resident	NN
cord-003091-uvfppirt	129	10	and	and	CC
cord-003091-uvfppirt	129	11	migratory	migratory	JJ
cord-003091-uvfppirt	129	12	DCs	dc	NNS
cord-003091-uvfppirt	129	13	seem	seem	VBP
cord-003091-uvfppirt	129	14	to	to	TO
cord-003091-uvfppirt	129	15	be	be	VB
cord-003091-uvfppirt	129	16	undoubted	undoubted	JJ
cord-003091-uvfppirt	129	17	(	(	-LRB-
cord-003091-uvfppirt	129	18	25	25	CD
cord-003091-uvfppirt	129	19	,	,	,
cord-003091-uvfppirt	129	20	105	105	CD
cord-003091-uvfppirt	129	21	)	)	-RRB-
cord-003091-uvfppirt	129	22	.	.	.
cord-003091-uvfppirt	130	1	Indeed	indeed	RB
cord-003091-uvfppirt	130	2	,	,	,
cord-003091-uvfppirt	130	3	Allenspach	Allenspach	NNP
cord-003091-uvfppirt	130	4	and	and	CC
cord-003091-uvfppirt	130	5	colleagues	colleague	NNS
cord-003091-uvfppirt	130	6	reported	report	VBD
cord-003091-uvfppirt	130	7	that	that	IN
cord-003091-uvfppirt	130	8	ag	ag	NNP
cord-003091-uvfppirt	130	9	presentation	presentation	NN
cord-003091-uvfppirt	130	10	by	by	IN
cord-003091-uvfppirt	130	11	LN	ln	NN
cord-003091-uvfppirt	130	12	-	-	HYPH
cord-003091-uvfppirt	130	13	resident	resident	JJ
cord-003091-uvfppirt	130	14	DCs	DCs	NNP
cord-003091-uvfppirt	130	15	few	few	JJ
cord-003091-uvfppirt	130	16	hours	hour	NNS
cord-003091-uvfppirt	130	17	after	after	IN
cord-003091-uvfppirt	130	18	the	the	DT
cord-003091-uvfppirt	130	19	infection	infection	NN
cord-003091-uvfppirt	130	20	is	be	VBZ
cord-003091-uvfppirt	130	21	required	require	VBN
cord-003091-uvfppirt	130	22	to	to	TO
cord-003091-uvfppirt	130	23	entrap	entrap	VB
cord-003091-uvfppirt	130	24	ag	ag	NNP
cord-003091-uvfppirt	130	25	-	-	HYPH
cord-003091-uvfppirt	130	26	specific	specific	JJ
cord-003091-uvfppirt	130	27	T	T	NNP
cord-003091-uvfppirt	130	28	cells	cell	NNS
cord-003091-uvfppirt	130	29	in	in	IN
cord-003091-uvfppirt	130	30	the	the	DT
cord-003091-uvfppirt	130	31	draining	drain	VBG
cord-003091-uvfppirt	130	32	LN	ln	NN
cord-003091-uvfppirt	130	33	and	and	CC
cord-003091-uvfppirt	130	34	to	to	TO
cord-003091-uvfppirt	130	35	favor	favor	VB
cord-003091-uvfppirt	130	36	an	an	DT
cord-003091-uvfppirt	130	37	optimal	optimal	JJ
cord-003091-uvfppirt	130	38	activation	activation	NN
cord-003091-uvfppirt	130	39	of	of	IN
cord-003091-uvfppirt	130	40	T	t	NN
cord-003091-uvfppirt	130	41	cells	cell	NNS
cord-003091-uvfppirt	130	42	by	by	IN
cord-003091-uvfppirt	130	43	migratory	migratory	JJ
cord-003091-uvfppirt	130	44	DCs	dc	NNS
cord-003091-uvfppirt	130	45	that	that	WDT
cord-003091-uvfppirt	130	46	arrive	arrive	VBP
cord-003091-uvfppirt	130	47	at	at	IN
cord-003091-uvfppirt	130	48	the	the	DT
cord-003091-uvfppirt	130	49	LN	ln	NN
cord-003091-uvfppirt	130	50	many	many	JJ
cord-003091-uvfppirt	130	51	hours	hour	NNS
cord-003091-uvfppirt	130	52	later	later	RB
cord-003091-uvfppirt	130	53	(	(	-LRB-
cord-003091-uvfppirt	130	54	106	106	CD
cord-003091-uvfppirt	130	55	)	)	-RRB-
cord-003091-uvfppirt	130	56	.	.	.
cord-003091-uvfppirt	131	1	It	-PRON-	PRP
cord-003091-uvfppirt	131	2	emerges	emerge	VBZ
cord-003091-uvfppirt	131	3	,	,	,
cord-003091-uvfppirt	131	4	therefore	therefore	RB
cord-003091-uvfppirt	131	5	,	,	,
cord-003091-uvfppirt	131	6	that	that	IN
cord-003091-uvfppirt	131	7	another	another	DT
cord-003091-uvfppirt	131	8	aspect	aspect	NN
cord-003091-uvfppirt	131	9	to	to	TO
cord-003091-uvfppirt	131	10	be	be	VB
cord-003091-uvfppirt	131	11	considered	consider	VBN
cord-003091-uvfppirt	131	12	for	for	IN
cord-003091-uvfppirt	131	13	the	the	DT
cord-003091-uvfppirt	131	14	identification	identification	NN
cord-003091-uvfppirt	131	15	of	of	IN
cord-003091-uvfppirt	131	16	efficacious	efficacious	JJ
cord-003091-uvfppirt	131	17	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	131	18	concerns	concern	VBZ
cord-003091-uvfppirt	131	19	the	the	DT
cord-003091-uvfppirt	131	20	type	type	NN
cord-003091-uvfppirt	131	21	of	of	IN
cord-003091-uvfppirt	131	22	DC	DC	NNP
cord-003091-uvfppirt	131	23	subset	subset	JJ
cord-003091-uvfppirt	131	24	to	to	TO
cord-003091-uvfppirt	131	25	be	be	VB
cord-003091-uvfppirt	131	26	targeted	target	VBN
cord-003091-uvfppirt	131	27	and	and	CC
cord-003091-uvfppirt	131	28	the	the	DT
cord-003091-uvfppirt	131	29	consequential	consequential	JJ
cord-003091-uvfppirt	131	30	effects	effect	NNS
cord-003091-uvfppirt	131	31	that	that	WDT
cord-003091-uvfppirt	131	32	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	131	33	imprint	imprint	VBP
cord-003091-uvfppirt	131	34	on	on	IN
cord-003091-uvfppirt	131	35	that	that	DT
cord-003091-uvfppirt	131	36	subset	subset	JJ
cord-003091-uvfppirt	131	37	.	.	.
cord-003091-uvfppirt	132	1	Adjuvants	adjuvant	NNS
cord-003091-uvfppirt	132	2	play	play	VBP
cord-003091-uvfppirt	132	3	a	a	DT
cord-003091-uvfppirt	132	4	pivotal	pivotal	JJ
cord-003091-uvfppirt	132	5	role	role	NN
cord-003091-uvfppirt	132	6	in	in	IN
cord-003091-uvfppirt	132	7	determining	determine	VBG
cord-003091-uvfppirt	132	8	tissue	tissue	NN
cord-003091-uvfppirt	132	9	-	-	HYPH
cord-003091-uvfppirt	132	10	resident	resident	NN
cord-003091-uvfppirt	132	11	DC	DC	NNP
cord-003091-uvfppirt	132	12	mobility	mobility	NN
cord-003091-uvfppirt	132	13	to	to	IN
cord-003091-uvfppirt	132	14	draining	drain	VBG
cord-003091-uvfppirt	132	15	LN	ln	NN
cord-003091-uvfppirt	132	16	and	and	CC
cord-003091-uvfppirt	132	17	efficiency	efficiency	NN
cord-003091-uvfppirt	132	18	of	of	IN
cord-003091-uvfppirt	132	19	T	T	NNP
cord-003091-uvfppirt	132	20	cell	cell	NN
cord-003091-uvfppirt	132	21	polarization	polarization	NN
cord-003091-uvfppirt	132	22	.	.	.
cord-003091-uvfppirt	133	1	Indeed	indeed	RB
cord-003091-uvfppirt	133	2	,	,	,
cord-003091-uvfppirt	133	3	dDCs	dDCs	NNP
cord-003091-uvfppirt	133	4	acquire	acquire	NN
cord-003091-uvfppirt	133	5	mobility	mobility	NN
cord-003091-uvfppirt	133	6	after	after	IN
cord-003091-uvfppirt	133	7	subcutaneous	subcutaneous	JJ
cord-003091-uvfppirt	133	8	injection	injection	NN
cord-003091-uvfppirt	133	9	of	of	IN
cord-003091-uvfppirt	133	10	Th1-specific	Th1-specific	NNP
cord-003091-uvfppirt	133	11	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	133	12	as	as	IN
cord-003091-uvfppirt	133	13	CpG	CpG	NNP
cord-003091-uvfppirt	133	14	and	and	CC
cord-003091-uvfppirt	133	15	LPS	LPS	NNP
cord-003091-uvfppirt	133	16	,	,	,
cord-003091-uvfppirt	133	17	but	but	CC
cord-003091-uvfppirt	133	18	not	not	RB
cord-003091-uvfppirt	133	19	with	with	IN
cord-003091-uvfppirt	133	20	Th2-specific	Th2-specific	NNP
cord-003091-uvfppirt	133	21	ones	one	NNS
cord-003091-uvfppirt	133	22	,	,	,
cord-003091-uvfppirt	133	23	as	as	IN
cord-003091-uvfppirt	133	24	papain	papain	NN
cord-003091-uvfppirt	133	25	,	,	,
cord-003091-uvfppirt	133	26	or	or	CC
cord-003091-uvfppirt	133	27	following	follow	VBG
cord-003091-uvfppirt	133	28	contact	contact	NN
cord-003091-uvfppirt	133	29	sensitization	sensitization	NN
cord-003091-uvfppirt	133	30	with	with	IN
cord-003091-uvfppirt	133	31	dibutyl	dibutyl	NN
cord-003091-uvfppirt	133	32	phthalate	phthalate	NN
cord-003091-uvfppirt	133	33	and	and	CC
cord-003091-uvfppirt	133	34	acetone	acetone	NN
cord-003091-uvfppirt	133	35	.	.	.
cord-003091-uvfppirt	134	1	Moreover	moreover	RB
cord-003091-uvfppirt	134	2	,	,	,
cord-003091-uvfppirt	134	3	dDCs	dDCs	NNP
cord-003091-uvfppirt	134	4	are	be	VBP
cord-003091-uvfppirt	134	5	sufficient	sufficient	JJ
cord-003091-uvfppirt	134	6	to	to	TO
cord-003091-uvfppirt	134	7	promote	promote	VB
cord-003091-uvfppirt	134	8	Th1	th1	NN
cord-003091-uvfppirt	134	9	and	and	CC
cord-003091-uvfppirt	134	10	Th2	th2	CD
cord-003091-uvfppirt	134	11	responses	response	NNS
cord-003091-uvfppirt	134	12	,	,	,
cord-003091-uvfppirt	134	13	while	while	IN
cord-003091-uvfppirt	134	14	LCs	lc	NNS
cord-003091-uvfppirt	134	15	are	be	VBP
cord-003091-uvfppirt	134	16	only	only	RB
cord-003091-uvfppirt	134	17	supportive	supportive	JJ
cord-003091-uvfppirt	134	18	of	of	IN
cord-003091-uvfppirt	134	19	Th1	Th1	NNP
cord-003091-uvfppirt	134	20	(	(	-LRB-
cord-003091-uvfppirt	134	21	107	107	CD
cord-003091-uvfppirt	134	22	)	)	-RRB-
cord-003091-uvfppirt	134	23	.	.	.
cord-003091-uvfppirt	135	1	This	this	DT
cord-003091-uvfppirt	135	2	evidence	evidence	NN
cord-003091-uvfppirt	135	3	underscore	underscore	VBP
cord-003091-uvfppirt	135	4	that	that	IN
cord-003091-uvfppirt	135	5	,	,	,
cord-003091-uvfppirt	135	6	in	in	IN
cord-003091-uvfppirt	135	7	addition	addition	NN
cord-003091-uvfppirt	135	8	to	to	IN
cord-003091-uvfppirt	135	9	the	the	DT
cord-003091-uvfppirt	135	10	polarizing	polarizing	JJ
cord-003091-uvfppirt	135	11	capabilities	capability	NNS
cord-003091-uvfppirt	135	12	of	of	IN
cord-003091-uvfppirt	135	13	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	135	14	,	,	,
cord-003091-uvfppirt	135	15	also	also	RB
cord-003091-uvfppirt	135	16	the	the	DT
cord-003091-uvfppirt	135	17	targeted	target	VBN
cord-003091-uvfppirt	135	18	DC	DC	NNP
cord-003091-uvfppirt	135	19	subset	subset	NN
cord-003091-uvfppirt	135	20	must	must	MD
cord-003091-uvfppirt	135	21	be	be	VB
cord-003091-uvfppirt	135	22	considered	consider	VBN
cord-003091-uvfppirt	135	23	to	to	TO
cord-003091-uvfppirt	135	24	elicit	elicit	VB
cord-003091-uvfppirt	135	25	specific	specific	JJ
cord-003091-uvfppirt	135	26	adaptive	adaptive	JJ
cord-003091-uvfppirt	135	27	immunity	immunity	NN
cord-003091-uvfppirt	135	28	.	.	.
cord-003091-uvfppirt	136	1	Indeed	indeed	RB
cord-003091-uvfppirt	136	2	,	,	,
cord-003091-uvfppirt	136	3	Antonialli	Antonialli	NNP
cord-003091-uvfppirt	136	4	and	and	CC
cord-003091-uvfppirt	136	5	colleagues	colleague	NNS
cord-003091-uvfppirt	136	6	reported	report	VBD
cord-003091-uvfppirt	136	7	differential	differential	JJ
cord-003091-uvfppirt	136	8	immune	immune	JJ
cord-003091-uvfppirt	136	9	responses	response	NNS
cord-003091-uvfppirt	136	10	when	when	WRB
cord-003091-uvfppirt	136	11	CD8α	CD8α	NNP
cord-003091-uvfppirt	136	12	+	+	CC
cord-003091-uvfppirt	136	13	and	and	CC
cord-003091-uvfppirt	136	14	CD8α	CD8α	NNP
cord-003091-uvfppirt	136	15	−	−	NNP
cord-003091-uvfppirt	136	16	DCs	dc	NNS
cord-003091-uvfppirt	136	17	were	be	VBD
cord-003091-uvfppirt	136	18	targeted	target	VBN
cord-003091-uvfppirt	136	19	with	with	IN
cord-003091-uvfppirt	136	20	the	the	DT
cord-003091-uvfppirt	136	21	same	same	JJ
cord-003091-uvfppirt	136	22	ag	ag	NN
cord-003091-uvfppirt	136	23	and	and	CC
cord-003091-uvfppirt	136	24	adjuvant	adjuvant	NN
cord-003091-uvfppirt	136	25	,	,	,
cord-003091-uvfppirt	136	26	either	either	CC
cord-003091-uvfppirt	136	27	CpG	CpG	NNP
cord-003091-uvfppirt	136	28	ODN	ODN	NNP
cord-003091-uvfppirt	136	29	or	or	CC
cord-003091-uvfppirt	136	30	Flagellin	Flagellin	NNP
cord-003091-uvfppirt	136	31	(	(	-LRB-
cord-003091-uvfppirt	136	32	108	108	CD
cord-003091-uvfppirt	136	33	)	)	-RRB-
cord-003091-uvfppirt	136	34	.	.	.
cord-003091-uvfppirt	137	1	In	in	IN
cord-003091-uvfppirt	137	2	addition	addition	NN
cord-003091-uvfppirt	137	3	,	,	,
cord-003091-uvfppirt	137	4	to	to	TO
cord-003091-uvfppirt	137	5	enhance	enhance	VB
cord-003091-uvfppirt	137	6	the	the	DT
cord-003091-uvfppirt	137	7	efficacy	efficacy	NN
cord-003091-uvfppirt	137	8	of	of	IN
cord-003091-uvfppirt	137	9	vaccination	vaccination	NN
cord-003091-uvfppirt	137	10	,	,	,
cord-003091-uvfppirt	137	11	the	the	DT
cord-003091-uvfppirt	137	12	coincident	coincident	JJ
cord-003091-uvfppirt	137	13	delivery	delivery	NN
cord-003091-uvfppirt	137	14	of	of	IN
cord-003091-uvfppirt	137	15	ag	ag	NNP
cord-003091-uvfppirt	137	16	and	and	CC
cord-003091-uvfppirt	137	17	PRR	PRR	NNP
cord-003091-uvfppirt	137	18	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	137	19	to	to	IN
cord-003091-uvfppirt	137	20	APCs	apc	NNS
cord-003091-uvfppirt	137	21	plays	play	VBZ
cord-003091-uvfppirt	137	22	a	a	DT
cord-003091-uvfppirt	137	23	crucial	crucial	JJ
cord-003091-uvfppirt	137	24	role	role	NN
cord-003091-uvfppirt	137	25	.	.	.
cord-003091-uvfppirt	138	1	Encouraging	encourage	VBG
cord-003091-uvfppirt	138	2	evidence	evidence	NN
cord-003091-uvfppirt	138	3	highlights	highlight	VBZ
cord-003091-uvfppirt	138	4	the	the	DT
cord-003091-uvfppirt	138	5	importance	importance	NN
cord-003091-uvfppirt	138	6	of	of	IN
cord-003091-uvfppirt	138	7	conjugation	conjugation	NN
cord-003091-uvfppirt	138	8	of	of	IN
cord-003091-uvfppirt	138	9	ag	ag	NNP
cord-003091-uvfppirt	138	10	with	with	IN
cord-003091-uvfppirt	138	11	PRR	PRR	NNP
cord-003091-uvfppirt	138	12	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	138	13	,	,	,
cord-003091-uvfppirt	138	14	since	since	IN
cord-003091-uvfppirt	138	15	it	-PRON-	PRP
cord-003091-uvfppirt	138	16	improves	improve	VBZ
cord-003091-uvfppirt	138	17	ag	ag	NNP
cord-003091-uvfppirt	138	18	uptake	uptake	NN
cord-003091-uvfppirt	138	19	,	,	,
cord-003091-uvfppirt	138	20	humoral	humoral	JJ
cord-003091-uvfppirt	138	21	and	and	CC
cord-003091-uvfppirt	138	22	cellular	cellular	JJ
cord-003091-uvfppirt	138	23	responses	response	NNS
cord-003091-uvfppirt	138	24	when	when	WRB
cord-003091-uvfppirt	138	25	compared	compare	VBN
cord-003091-uvfppirt	138	26	to	to	IN
cord-003091-uvfppirt	138	27	vaccination	vaccination	NN
cord-003091-uvfppirt	138	28	with	with	IN
cord-003091-uvfppirt	138	29	ag	ag	NNP
cord-003091-uvfppirt	138	30	codelivered	codelivere	VBN
cord-003091-uvfppirt	138	31	with	with	IN
cord-003091-uvfppirt	138	32	free	free	JJ
cord-003091-uvfppirt	138	33	TLR	TLR	NNP
cord-003091-uvfppirt	138	34	ligands	ligand	NNS
cord-003091-uvfppirt	138	35	(	(	-LRB-
cord-003091-uvfppirt	138	36	109	109	CD
cord-003091-uvfppirt	138	37	)	)	-RRB-
cord-003091-uvfppirt	138	38	.	.	.
cord-003091-uvfppirt	139	1	These	these	DT
cord-003091-uvfppirt	139	2	findings	finding	NNS
cord-003091-uvfppirt	139	3	strengthen	strengthen	VBP
cord-003091-uvfppirt	139	4	the	the	DT
cord-003091-uvfppirt	139	5	notion	notion	NN
cord-003091-uvfppirt	139	6	that	that	IN
cord-003091-uvfppirt	139	7	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	139	8	are	be	VBP
cord-003091-uvfppirt	139	9	formidable	formidable	JJ
cord-003091-uvfppirt	139	10	chiefs	chief	NNS
cord-003091-uvfppirt	139	11	in	in	IN
cord-003091-uvfppirt	139	12	shaping	shape	VBG
cord-003091-uvfppirt	139	13	immune	immune	JJ
cord-003091-uvfppirt	139	14	responses	response	NNS
cord-003091-uvfppirt	139	15	and	and	CC
cord-003091-uvfppirt	139	16	must	must	MD
cord-003091-uvfppirt	139	17	be	be	VB
cord-003091-uvfppirt	139	18	selected	select	VBN
cord-003091-uvfppirt	139	19	for	for	IN
cord-003091-uvfppirt	139	20	the	the	DT
cord-003091-uvfppirt	139	21	outcomes	outcome	NNS
cord-003091-uvfppirt	139	22	they	-PRON-	PRP
cord-003091-uvfppirt	139	23	promote	promote	VBP
cord-003091-uvfppirt	139	24	,	,	,
cord-003091-uvfppirt	139	25	in	in	IN
cord-003091-uvfppirt	139	26	chemical	chemical	NNP
cord-003091-uvfppirt	139	27	association	association	NNP
cord-003091-uvfppirt	139	28	to	to	IN
cord-003091-uvfppirt	139	29	the	the	DT
cord-003091-uvfppirt	139	30	ag	ag	NNP
cord-003091-uvfppirt	139	31	of	of	IN
cord-003091-uvfppirt	139	32	interest	interest	NNP
cord-003091-uvfppirt	139	33	.	.	.
cord-003091-uvfppirt	140	1	The	the	DT
cord-003091-uvfppirt	140	2	traditional	traditional	JJ
cord-003091-uvfppirt	140	3	vaccination	vaccination	NN
cord-003091-uvfppirt	140	4	approaches	approach	NNS
cord-003091-uvfppirt	140	5	consisted	consist	VBN
cord-003091-uvfppirt	140	6	in	in	IN
cord-003091-uvfppirt	140	7	the	the	DT
cord-003091-uvfppirt	140	8	adminis	adminis	NNP
cord-003091-uvfppirt	140	9	tration	tration	NN
cord-003091-uvfppirt	140	10	of	of	IN
cord-003091-uvfppirt	140	11	live	live	JJ
cord-003091-uvfppirt	140	12	or	or	CC
cord-003091-uvfppirt	140	13	attenuated	attenuated	JJ
cord-003091-uvfppirt	140	14	micro	micro	NNS
cord-003091-uvfppirt	140	15	-	-	HYPH
cord-003091-uvfppirt	140	16	organisms	organism	NNS
cord-003091-uvfppirt	140	17	.	.	.
cord-003091-uvfppirt	141	1	Up	up	IN
cord-003091-uvfppirt	141	2	to	to	IN
cord-003091-uvfppirt	141	3	now	now	RB
cord-003091-uvfppirt	141	4	,	,	,
cord-003091-uvfppirt	141	5	several	several	JJ
cord-003091-uvfppirt	141	6	innovative	innovative	JJ
cord-003091-uvfppirt	141	7	strategies	strategy	NNS
cord-003091-uvfppirt	141	8	have	have	VBP
cord-003091-uvfppirt	141	9	emerged	emerge	VBN
cord-003091-uvfppirt	141	10	to	to	TO
cord-003091-uvfppirt	141	11	address	address	VB
cord-003091-uvfppirt	141	12	the	the	DT
cord-003091-uvfppirt	141	13	need	need	NN
cord-003091-uvfppirt	141	14	for	for	IN
cord-003091-uvfppirt	141	15	efficient	efficient	JJ
cord-003091-uvfppirt	141	16	vaccines	vaccine	NNS
cord-003091-uvfppirt	141	17	,	,	,
cord-003091-uvfppirt	141	18	especially	especially	RB
cord-003091-uvfppirt	141	19	against	against	IN
cord-003091-uvfppirt	141	20	diseases	disease	NNS
cord-003091-uvfppirt	141	21	that	that	WDT
cord-003091-uvfppirt	141	22	are	be	VBP
cord-003091-uvfppirt	141	23	critical	critical	JJ
cord-003091-uvfppirt	141	24	to	to	TO
cord-003091-uvfppirt	141	25	treat	treat	VB
cord-003091-uvfppirt	141	26	,	,	,
cord-003091-uvfppirt	141	27	as	as	IN
cord-003091-uvfppirt	141	28	cancer	cancer	NN
cord-003091-uvfppirt	141	29	and	and	CC
cord-003091-uvfppirt	141	30	the	the	DT
cord-003091-uvfppirt	141	31	infectious	infectious	JJ
cord-003091-uvfppirt	141	32	diseases	disease	NNS
cord-003091-uvfppirt	141	33	already	already	RB
cord-003091-uvfppirt	141	34	mentioned	mention	VBN
cord-003091-uvfppirt	141	35	.	.	.
cord-003091-uvfppirt	142	1	The	the	DT
cord-003091-uvfppirt	142	2	main	main	JJ
cord-003091-uvfppirt	142	3	purpose	purpose	NN
cord-003091-uvfppirt	142	4	is	be	VBZ
cord-003091-uvfppirt	142	5	to	to	TO
cord-003091-uvfppirt	142	6	convey	convey	VB
cord-003091-uvfppirt	142	7	ag	ag	NNP
cord-003091-uvfppirt	142	8	,	,	,
cord-003091-uvfppirt	142	9	adjuvant	adjuvant	NN
cord-003091-uvfppirt	142	10	,	,	,
cord-003091-uvfppirt	142	11	and	and	CC
cord-003091-uvfppirt	142	12	targeting	targeting	NN
cord-003091-uvfppirt	142	13	-	-	HYPH
cord-003091-uvfppirt	142	14	molecule	molecule	NN
cord-003091-uvfppirt	142	15	in	in	IN
cord-003091-uvfppirt	142	16	a	a	DT
cord-003091-uvfppirt	142	17	unique	unique	JJ
cord-003091-uvfppirt	142	18	compound	compound	NN
cord-003091-uvfppirt	142	19	to	to	TO
cord-003091-uvfppirt	142	20	increase	increase	VB
cord-003091-uvfppirt	142	21	the	the	DT
cord-003091-uvfppirt	142	22	efficacy	efficacy	NN
cord-003091-uvfppirt	142	23	of	of	IN
cord-003091-uvfppirt	142	24	the	the	DT
cord-003091-uvfppirt	142	25	ag	ag	JJ
cord-003091-uvfppirt	142	26	-	-	HYPH
cord-003091-uvfppirt	142	27	specific	specific	JJ
cord-003091-uvfppirt	142	28	immune	immune	JJ
cord-003091-uvfppirt	142	29	response	response	NN
cord-003091-uvfppirt	142	30	.	.	.
cord-003091-uvfppirt	143	1	To	to	TO
cord-003091-uvfppirt	143	2	address	address	VB
cord-003091-uvfppirt	143	3	this	this	DT
cord-003091-uvfppirt	143	4	issue	issue	NN
cord-003091-uvfppirt	143	5	,	,	,
cord-003091-uvfppirt	143	6	different	different	JJ
cord-003091-uvfppirt	143	7	approaches	approach	NNS
cord-003091-uvfppirt	143	8	have	have	VBP
cord-003091-uvfppirt	143	9	been	be	VBN
cord-003091-uvfppirt	143	10	explored	explore	VBN
cord-003091-uvfppirt	143	11	or	or	CC
cord-003091-uvfppirt	143	12	are	be	VBP
cord-003091-uvfppirt	143	13	currently	currently	RB
cord-003091-uvfppirt	143	14	under	under	IN
cord-003091-uvfppirt	143	15	investigation	investigation	NN
cord-003091-uvfppirt	143	16	,	,	,
cord-003091-uvfppirt	143	17	as	as	IN
cord-003091-uvfppirt	143	18	shown	show	VBN
cord-003091-uvfppirt	143	19	in	in	IN
cord-003091-uvfppirt	143	20	Figure	figure	NN
cord-003091-uvfppirt	143	21	2	2	CD
cord-003091-uvfppirt	143	22	.	.	.
cord-003091-uvfppirt	144	1	Recombinant	recombinant	JJ
cord-003091-uvfppirt	144	2	antibody	antibody	NN
cord-003091-uvfppirt	144	3	(	(	-LRB-
cord-003091-uvfppirt	144	4	rAb	rAb	NNP
cord-003091-uvfppirt	144	5	)	)	-RRB-
cord-003091-uvfppirt	144	6	represents	represent	VBZ
cord-003091-uvfppirt	144	7	a	a	DT
cord-003091-uvfppirt	144	8	feasible	feasible	JJ
cord-003091-uvfppirt	144	9	option	option	NN
cord-003091-uvfppirt	144	10	.	.	.
cord-003091-uvfppirt	145	1	This	this	DT
cord-003091-uvfppirt	145	2	approach	approach	NN
cord-003091-uvfppirt	145	3	exploits	exploit	VBZ
cord-003091-uvfppirt	145	4	the	the	DT
cord-003091-uvfppirt	145	5	possibility	possibility	NN
cord-003091-uvfppirt	145	6	to	to	TO
cord-003091-uvfppirt	145	7	chemically	chemically	RB
cord-003091-uvfppirt	145	8	fuse	fuse	VB
cord-003091-uvfppirt	145	9	peptide	peptide	NNP
cord-003091-uvfppirt	145	10	ag	ag	NNP
cord-003091-uvfppirt	145	11	,	,	,
cord-003091-uvfppirt	145	12	adjuvant	adjuvant	NN
cord-003091-uvfppirt	145	13	,	,	,
cord-003091-uvfppirt	145	14	and	and	CC
cord-003091-uvfppirt	145	15	targeting	targeting	NN
cord-003091-uvfppirt	145	16	-	-	HYPH
cord-003091-uvfppirt	145	17	molecule	molecule	NN
cord-003091-uvfppirt	145	18	to	to	IN
cord-003091-uvfppirt	145	19	Ab	Ab	NNP
cord-003091-uvfppirt	145	20	to	to	TO
cord-003091-uvfppirt	145	21	tailor	tailor	VB
cord-003091-uvfppirt	145	22	DCs	DCs	NNP
cord-003091-uvfppirt	145	23	targeting	target	VBG
cord-003091-uvfppirt	145	24	(	(	-LRB-
cord-003091-uvfppirt	145	25	110	110	CD
cord-003091-uvfppirt	145	26	)	)	-RRB-
cord-003091-uvfppirt	145	27	(	(	-LRB-
cord-003091-uvfppirt	145	28	111	111	CD
cord-003091-uvfppirt	145	29	)	)	-RRB-
cord-003091-uvfppirt	145	30	(	(	-LRB-
cord-003091-uvfppirt	145	31	112	112	CD
cord-003091-uvfppirt	145	32	)	)	-RRB-
cord-003091-uvfppirt	145	33	.	.	.
cord-003091-uvfppirt	146	1	In	in	IN
cord-003091-uvfppirt	146	2	addition	addition	NN
cord-003091-uvfppirt	146	3	to	to	TO
cord-003091-uvfppirt	146	4	rAb	rab	VB
cord-003091-uvfppirt	146	5	,	,	,
cord-003091-uvfppirt	146	6	single	single	JJ
cord-003091-uvfppirt	146	7	-	-	HYPH
cord-003091-uvfppirt	146	8	chain	chain	NN
cord-003091-uvfppirt	146	9	fragments	fragment	NNS
cord-003091-uvfppirt	146	10	variable	variable	JJ
cord-003091-uvfppirt	146	11	(	(	-LRB-
cord-003091-uvfppirt	146	12	scFv	scFv	NNP
cord-003091-uvfppirt	146	13	)	)	-RRB-
cord-003091-uvfppirt	146	14	revealed	reveal	VBN
cord-003091-uvfppirt	146	15	to	to	TO
cord-003091-uvfppirt	146	16	be	be	VB
cord-003091-uvfppirt	146	17	an	an	DT
cord-003091-uvfppirt	146	18	appealing	appeal	VBG
cord-003091-uvfppirt	146	19	strategy	strategy	NN
cord-003091-uvfppirt	146	20	due	due	IN
cord-003091-uvfppirt	146	21	to	to	IN
cord-003091-uvfppirt	146	22	their	-PRON-	PRP$
cord-003091-uvfppirt	146	23	reduced	reduce	VBN
cord-003091-uvfppirt	146	24	size	size	NN
cord-003091-uvfppirt	146	25	and	and	CC
cord-003091-uvfppirt	146	26	enhanced	enhanced	JJ
cord-003091-uvfppirt	146	27	infiltration	infiltration	NN
cord-003091-uvfppirt	146	28	into	into	IN
cord-003091-uvfppirt	146	29	tissues	tissue	NNS
cord-003091-uvfppirt	146	30	,	,	,
cord-003091-uvfppirt	146	31	as	as	IN
cord-003091-uvfppirt	146	32	in	in	IN
cord-003091-uvfppirt	146	33	solid	solid	JJ
cord-003091-uvfppirt	146	34	tumors	tumor	NNS
cord-003091-uvfppirt	146	35	(	(	-LRB-
cord-003091-uvfppirt	146	36	113	113	CD
cord-003091-uvfppirt	146	37	)	)	-RRB-
cord-003091-uvfppirt	146	38	.	.	.
cord-003091-uvfppirt	147	1	Other	other	JJ
cord-003091-uvfppirt	147	2	approaches	approach	NNS
cord-003091-uvfppirt	147	3	involve	involve	VBP
cord-003091-uvfppirt	147	4	the	the	DT
cord-003091-uvfppirt	147	5	use	use	NN
cord-003091-uvfppirt	147	6	of	of	IN
cord-003091-uvfppirt	147	7	nano	nano	NN
cord-003091-uvfppirt	147	8	-	-	HYPH
cord-003091-uvfppirt	147	9	carries	carry	VBZ
cord-003091-uvfppirt	147	10	as	as	IN
cord-003091-uvfppirt	147	11	vehicles	vehicle	NNS
cord-003091-uvfppirt	147	12	.	.	.
cord-003091-uvfppirt	148	1	The	the	DT
cord-003091-uvfppirt	148	2	most	most	RBS
cord-003091-uvfppirt	148	3	promising	promising	JJ
cord-003091-uvfppirt	148	4	solution	solution	NN
cord-003091-uvfppirt	148	5	to	to	TO
cord-003091-uvfppirt	148	6	target	target	VB
cord-003091-uvfppirt	148	7	phagocytes	phagocyte	NNS
cord-003091-uvfppirt	148	8	is	be	VBZ
cord-003091-uvfppirt	148	9	indeed	indeed	RB
cord-003091-uvfppirt	148	10	the	the	DT
cord-003091-uvfppirt	148	11	use	use	NN
cord-003091-uvfppirt	148	12	of	of	IN
cord-003091-uvfppirt	148	13	particulate	particulate	NN
cord-003091-uvfppirt	148	14	materials	material	NNS
cord-003091-uvfppirt	148	15	(	(	-LRB-
cord-003091-uvfppirt	148	16	114	114	CD
cord-003091-uvfppirt	148	17	,	,	,
cord-003091-uvfppirt	148	18	115	115	CD
cord-003091-uvfppirt	148	19	)	)	-RRB-
cord-003091-uvfppirt	148	20	.	.	.
cord-003091-uvfppirt	149	1	Nanoparticles	nanoparticle	NNS
cord-003091-uvfppirt	149	2	(	(	-LRB-
cord-003091-uvfppirt	149	3	NPs	NPs	NNP
cord-003091-uvfppirt	149	4	)	)	-RRB-
cord-003091-uvfppirt	149	5	are	be	VBP
cord-003091-uvfppirt	149	6	the	the	DT
cord-003091-uvfppirt	149	7	best	good	JJS
cord-003091-uvfppirt	149	8	candidates	candidate	NNS
cord-003091-uvfppirt	149	9	as	as	IN
cord-003091-uvfppirt	149	10	delivery	delivery	NN
cord-003091-uvfppirt	149	11	system	system	NN
cord-003091-uvfppirt	149	12	,	,	,
cord-003091-uvfppirt	149	13	since	since	IN
cord-003091-uvfppirt	149	14	they	-PRON-	PRP
cord-003091-uvfppirt	149	15	can	can	MD
cord-003091-uvfppirt	149	16	be	be	VB
cord-003091-uvfppirt	149	17	manipulated	manipulate	VBN
cord-003091-uvfppirt	149	18	to	to	IN
cord-003091-uvfppirt	149	19	efficiently	efficiently	RB
cord-003091-uvfppirt	149	20	and	and	CC
cord-003091-uvfppirt	149	21	predominantly	predominantly	RB
cord-003091-uvfppirt	149	22	target	target	VB
cord-003091-uvfppirt	149	23	phagocytes	phagocyte	NNS
cord-003091-uvfppirt	149	24	.	.	.
cord-003091-uvfppirt	150	1	This	this	DT
cord-003091-uvfppirt	150	2	is	be	VBZ
cord-003091-uvfppirt	150	3	possible	possible	JJ
cord-003091-uvfppirt	150	4	,	,	,
cord-003091-uvfppirt	150	5	thanks	thank	NNS
cord-003091-uvfppirt	150	6	to	to	IN
cord-003091-uvfppirt	150	7	the	the	DT
cord-003091-uvfppirt	150	8	versatility	versatility	NN
cord-003091-uvfppirt	150	9	of	of	IN
cord-003091-uvfppirt	150	10	NPs	NPs	NNPS
cord-003091-uvfppirt	150	11	due	due	JJ
cord-003091-uvfppirt	150	12	to	to	IN
cord-003091-uvfppirt	150	13	:	:	:
cord-003091-uvfppirt	150	14	(	(	-LRB-
cord-003091-uvfppirt	150	15	i	i	NN
cord-003091-uvfppirt	150	16	)	)	-RRB-
cord-003091-uvfppirt	151	1	the	the	DT
cord-003091-uvfppirt	151	2	large	large	JJ
cord-003091-uvfppirt	151	3	amounts	amount	NNS
cord-003091-uvfppirt	151	4	of	of	IN
cord-003091-uvfppirt	151	5	existing	exist	VBG
cord-003091-uvfppirt	151	6	different	different	JJ
cord-003091-uvfppirt	151	7	nanomaterials	nanomaterial	NNS
cord-003091-uvfppirt	151	8	;	;	,
cord-003091-uvfppirt	151	9	(	(	-LRB-
cord-003091-uvfppirt	151	10	ii	ii	NN
cord-003091-uvfppirt	151	11	)	)	-RRB-
cord-003091-uvfppirt	152	1	the	the	DT
cord-003091-uvfppirt	152	2	possibility	possibility	NN
cord-003091-uvfppirt	152	3	to	to	TO
cord-003091-uvfppirt	152	4	adjust	adjust	VB
cord-003091-uvfppirt	152	5	their	-PRON-	PRP$
cord-003091-uvfppirt	152	6	size	size	NN
cord-003091-uvfppirt	152	7	,	,	,
cord-003091-uvfppirt	152	8	morphology	morphology	NN
cord-003091-uvfppirt	152	9	,	,	,
cord-003091-uvfppirt	152	10	and	and	CC
cord-003091-uvfppirt	152	11	deformability	deformability	NN
cord-003091-uvfppirt	152	12	with	with	IN
cord-003091-uvfppirt	152	13	great	great	JJ
cord-003091-uvfppirt	152	14	precision	precision	NN
cord-003091-uvfppirt	152	15	;	;	,
cord-003091-uvfppirt	152	16	(	(	-LRB-
cord-003091-uvfppirt	152	17	iii	iii	NN
cord-003091-uvfppirt	152	18	)	)	-RRB-
cord-003091-uvfppirt	153	1	the	the	DT
cord-003091-uvfppirt	153	2	possibility	possibility	NN
cord-003091-uvfppirt	153	3	to	to	TO
cord-003091-uvfppirt	153	4	load	load	VB
cord-003091-uvfppirt	153	5	virtually	virtually	RB
cord-003091-uvfppirt	153	6	any	any	DT
cord-003091-uvfppirt	153	7	different	different	JJ
cord-003091-uvfppirt	153	8	type	type	NN
cord-003091-uvfppirt	153	9	of	of	IN
cord-003091-uvfppirt	153	10	drug	drug	NN
cord-003091-uvfppirt	153	11	molecules	molecule	NNS
cord-003091-uvfppirt	153	12	(	(	-LRB-
cord-003091-uvfppirt	153	13	116	116	CD
cord-003091-uvfppirt	153	14	)	)	-RRB-
cord-003091-uvfppirt	153	15	.	.	.
cord-003091-uvfppirt	154	1	Viral	viral	JJ
cord-003091-uvfppirt	154	2	vectors	vector	NNS
cord-003091-uvfppirt	154	3	-	-	HYPH
cord-003091-uvfppirt	154	4	based	base	VBN
cord-003091-uvfppirt	154	5	vaccines	vaccine	NNS
cord-003091-uvfppirt	154	6	or	or	CC
cord-003091-uvfppirt	154	7	virus	virus	NN
cord-003091-uvfppirt	154	8	-	-	HYPH
cord-003091-uvfppirt	154	9	like	like	JJ
cord-003091-uvfppirt	154	10	particles	particle	NNS
cord-003091-uvfppirt	154	11	rely	rely	VBP
cord-003091-uvfppirt	154	12	on	on	IN
cord-003091-uvfppirt	154	13	the	the	DT
cord-003091-uvfppirt	154	14	intrinsic	intrinsic	JJ
cord-003091-uvfppirt	154	15	capability	capability	NN
cord-003091-uvfppirt	154	16	of	of	IN
cord-003091-uvfppirt	154	17	viruses	virus	NNS
cord-003091-uvfppirt	154	18	to	to	TO
cord-003091-uvfppirt	154	19	infect	infect	VB
cord-003091-uvfppirt	154	20	cells	cell	NNS
cord-003091-uvfppirt	154	21	and	and	CC
cord-003091-uvfppirt	154	22	exploit	exploit	VB
cord-003091-uvfppirt	154	23	their	-PRON-	PRP$
cord-003091-uvfppirt	154	24	protein	protein	NN
cord-003091-uvfppirt	154	25	-	-	HYPH
cord-003091-uvfppirt	154	26	encoding	encode	VBG
cord-003091-uvfppirt	154	27	machinery	machinery	NN
cord-003091-uvfppirt	154	28	,	,	,
cord-003091-uvfppirt	154	29	allowing	allow	VBG
cord-003091-uvfppirt	154	30	expression	expression	NN
cord-003091-uvfppirt	154	31	in	in	IN
cord-003091-uvfppirt	154	32	the	the	DT
cord-003091-uvfppirt	154	33	cytosol	cytosol	NN
cord-003091-uvfppirt	154	34	of	of	IN
cord-003091-uvfppirt	154	35	the	the	DT
cord-003091-uvfppirt	154	36	engineered	engineer	VBN
cord-003091-uvfppirt	154	37	plasmid	plasmid	NN
cord-003091-uvfppirt	154	38	-	-	HYPH
cord-003091-uvfppirt	154	39	genes	gene	NNS
cord-003091-uvfppirt	154	40	,	,	,
cord-003091-uvfppirt	154	41	as	as	IN
cord-003091-uvfppirt	154	42	ag	ag	NNP
cord-003091-uvfppirt	154	43	,	,	,
cord-003091-uvfppirt	154	44	costimulatory	costimulatory	NNP
cord-003091-uvfppirt	154	45	molecules	molecule	NNS
cord-003091-uvfppirt	154	46	,	,	,
cord-003091-uvfppirt	154	47	cytokines	cytokine	NNS
cord-003091-uvfppirt	154	48	,	,	,
cord-003091-uvfppirt	154	49	and	and	CC
cord-003091-uvfppirt	154	50	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	154	51	,	,	,
cord-003091-uvfppirt	154	52	providing	provide	VBG
cord-003091-uvfppirt	154	53	the	the	DT
cord-003091-uvfppirt	154	54	bases	basis	NNS
cord-003091-uvfppirt	154	55	for	for	IN
cord-003091-uvfppirt	154	56	strong	strong	JJ
cord-003091-uvfppirt	154	57	CTL	CTL	NNP
cord-003091-uvfppirt	154	58	induction	induction	NN
cord-003091-uvfppirt	154	59	(	(	-LRB-
cord-003091-uvfppirt	154	60	117	117	CD
cord-003091-uvfppirt	154	61	)	)	-RRB-
cord-003091-uvfppirt	154	62	.	.	.
cord-003091-uvfppirt	155	1	On	on	IN
cord-003091-uvfppirt	155	2	the	the	DT
cord-003091-uvfppirt	155	3	other	other	JJ
cord-003091-uvfppirt	155	4	hand	hand	NN
cord-003091-uvfppirt	155	5	,	,	,
cord-003091-uvfppirt	155	6	naked	naked	JJ
cord-003091-uvfppirt	155	7	DNA	dna	NN
cord-003091-uvfppirt	155	8	can	can	MD
cord-003091-uvfppirt	155	9	be	be	VB
cord-003091-uvfppirt	155	10	directly	directly	RB
cord-003091-uvfppirt	155	11	injected	inject	VBN
cord-003091-uvfppirt	155	12	or	or	CC
cord-003091-uvfppirt	155	13	conjugated	conjugate	VBN
cord-003091-uvfppirt	155	14	to	to	IN
cord-003091-uvfppirt	155	15	nano	nano	NN
cord-003091-uvfppirt	155	16	-	-	HYPH
cord-003091-uvfppirt	155	17	carriers	carrier	NNS
cord-003091-uvfppirt	155	18	to	to	TO
cord-003091-uvfppirt	155	19	favor	favor	VB
cord-003091-uvfppirt	155	20	specific	specific	JJ
cord-003091-uvfppirt	155	21	targeting	targeting	NN
cord-003091-uvfppirt	155	22	.	.	.
cord-003091-uvfppirt	156	1	The	the	DT
cord-003091-uvfppirt	156	2	easy	easy	JJ
cord-003091-uvfppirt	156	3	designing	designing	NN
cord-003091-uvfppirt	156	4	of	of	IN
cord-003091-uvfppirt	156	5	nano	nano	NN
cord-003091-uvfppirt	156	6	-	-	HYPH
cord-003091-uvfppirt	156	7	carriers	carrier	NNS
cord-003091-uvfppirt	156	8	-	-	HYPH
cord-003091-uvfppirt	156	9	based	base	VBN
cord-003091-uvfppirt	156	10	vaccines	vaccine	NNS
cord-003091-uvfppirt	156	11	along	along	IN
cord-003091-uvfppirt	156	12	with	with	IN
cord-003091-uvfppirt	156	13	their	-PRON-	PRP$
cord-003091-uvfppirt	156	14	multi	multi	JJ
cord-003091-uvfppirt	156	15	-	-	JJ
cord-003091-uvfppirt	156	16	component	component	JJ
cord-003091-uvfppirt	156	17	loading	loading	NN
cord-003091-uvfppirt	156	18	feature	feature	NN
cord-003091-uvfppirt	156	19	improve	improve	NN
cord-003091-uvfppirt	156	20	targeting	target	VBG
cord-003091-uvfppirt	156	21	of	of	IN
cord-003091-uvfppirt	156	22	specific	specific	JJ
cord-003091-uvfppirt	156	23	subsets	subset	NNS
cord-003091-uvfppirt	156	24	(	(	-LRB-
cord-003091-uvfppirt	156	25	118	118	CD
cord-003091-uvfppirt	156	26	)	)	-RRB-
cord-003091-uvfppirt	156	27	and	and	CC
cord-003091-uvfppirt	156	28	shape	shape	VB
cord-003091-uvfppirt	156	29	immune	immune	JJ
cord-003091-uvfppirt	156	30	responses	response	NNS
cord-003091-uvfppirt	156	31	(	(	-LRB-
cord-003091-uvfppirt	156	32	119	119	CD
cord-003091-uvfppirt	156	33	,	,	,
cord-003091-uvfppirt	156	34	120	120	CD
cord-003091-uvfppirt	156	35	)	)	-RRB-
cord-003091-uvfppirt	156	36	,	,	,
cord-003091-uvfppirt	156	37	favoring	favor	VBG
cord-003091-uvfppirt	156	38	their	-PRON-	PRP$
cord-003091-uvfppirt	156	39	application	application	NN
cord-003091-uvfppirt	156	40	in	in	IN
cord-003091-uvfppirt	156	41	several	several	JJ
cord-003091-uvfppirt	156	42	fields	field	NNS
cord-003091-uvfppirt	156	43	.	.	.
cord-003091-uvfppirt	157	1	In	in	IN
cord-003091-uvfppirt	157	2	a	a	DT
cord-003091-uvfppirt	157	3	cancer	cancer	NN
cord-003091-uvfppirt	157	4	setting	setting	NN
cord-003091-uvfppirt	157	5	,	,	,
cord-003091-uvfppirt	157	6	nano	nano	NN
cord-003091-uvfppirt	157	7	-	-	HYPH
cord-003091-uvfppirt	157	8	carriers	carrier	NNS
cord-003091-uvfppirt	157	9	allow	allow	VBP
cord-003091-uvfppirt	157	10	to	to	TO
cord-003091-uvfppirt	157	11	avoid	avoid	VB
cord-003091-uvfppirt	157	12	killing	kill	VBG
cord-003091-uvfppirt	157	13	of	of	IN
cord-003091-uvfppirt	157	14	healthy	healthy	JJ
cord-003091-uvfppirt	157	15	cells	cell	NNS
cord-003091-uvfppirt	157	16	,	,	,
cord-003091-uvfppirt	157	17	by	by	IN
cord-003091-uvfppirt	157	18	delivering	deliver	VBG
cord-003091-uvfppirt	157	19	tumor	tumor	NN
cord-003091-uvfppirt	157	20	ags	ags	NNP
cord-003091-uvfppirt	157	21	or	or	CC
cord-003091-uvfppirt	157	22	DNA	dna	NN
cord-003091-uvfppirt	157	23	encoding	encode	VBG
cord-003091-uvfppirt	157	24	these	these	DT
cord-003091-uvfppirt	157	25	peptides	peptide	NNS
cord-003091-uvfppirt	157	26	to	to	IN
cord-003091-uvfppirt	157	27	APCs	apc	NNS
cord-003091-uvfppirt	157	28	,	,	,
cord-003091-uvfppirt	157	29	inducing	induce	VBG
cord-003091-uvfppirt	157	30	specific	specific	JJ
cord-003091-uvfppirt	157	31	antitumor	antitumor	JJ
cord-003091-uvfppirt	157	32	responses	response	NNS
cord-003091-uvfppirt	157	33	.	.	.
cord-003091-uvfppirt	158	1	Indeed	indeed	RB
cord-003091-uvfppirt	158	2	,	,	,
cord-003091-uvfppirt	158	3	NPs	NPs	NNPS
cord-003091-uvfppirt	158	4	allow	allow	VBP
cord-003091-uvfppirt	158	5	endocytosis	endocytosis	NN
cord-003091-uvfppirt	158	6	and	and	CC
cord-003091-uvfppirt	158	7	MHC	MHC	NNP
cord-003091-uvfppirt	158	8	presentation	presentation	NN
cord-003091-uvfppirt	158	9	on	on	IN
cord-003091-uvfppirt	158	10	both	both	DT
cord-003091-uvfppirt	158	11	class	class	NN
cord-003091-uvfppirt	158	12	I	i	NN
cord-003091-uvfppirt	158	13	and	and	CC
cord-003091-uvfppirt	158	14	II	II	NNP
cord-003091-uvfppirt	158	15	(	(	-LRB-
cord-003091-uvfppirt	158	16	121	121	CD
cord-003091-uvfppirt	158	17	)	)	-RRB-
cord-003091-uvfppirt	158	18	eliciting	elicit	VBG
cord-003091-uvfppirt	158	19	broad	broad	JJ
cord-003091-uvfppirt	158	20	adaptive	adaptive	JJ
cord-003091-uvfppirt	158	21	immunity	immunity	NN
cord-003091-uvfppirt	158	22	,	,	,
cord-003091-uvfppirt	158	23	even	even	RB
cord-003091-uvfppirt	158	24	against	against	IN
cord-003091-uvfppirt	158	25	cancer	cancer	NN
cord-003091-uvfppirt	158	26	cells	cell	NNS
cord-003091-uvfppirt	158	27	.	.	.
cord-003091-uvfppirt	159	1	Rosalia	Rosalia	NNP
cord-003091-uvfppirt	159	2	and	and	CC
cord-003091-uvfppirt	159	3	colleagues	colleague	NNS
cord-003091-uvfppirt	159	4	designed	design	VBD
cord-003091-uvfppirt	159	5	a	a	DT
cord-003091-uvfppirt	159	6	polymer	polymer	NN
cord-003091-uvfppirt	159	7	-	-	HYPH
cord-003091-uvfppirt	159	8	based	base	VBN
cord-003091-uvfppirt	159	9	biodegradable	biodegradable	JJ
cord-003091-uvfppirt	159	10	poly(lactic	poly(lactic	JJ
cord-003091-uvfppirt	159	11	-	-	HYPH
cord-003091-uvfppirt	159	12	co	co	NN
cord-003091-uvfppirt	159	13	-	-	JJ
cord-003091-uvfppirt	159	14	glycolic	glycolic	JJ
cord-003091-uvfppirt	159	15	acid	acid	NN
cord-003091-uvfppirt	159	16	)	)	-RRB-
cord-003091-uvfppirt	159	17	PLGA	PLGA	NNP
cord-003091-uvfppirt	159	18	NPs	NPs	NNP
cord-003091-uvfppirt	159	19	loaded	load	VBN
cord-003091-uvfppirt	159	20	with	with	IN
cord-003091-uvfppirt	159	21	ag	ag	NNP
cord-003091-uvfppirt	159	22	,	,	,
cord-003091-uvfppirt	159	23	Pam3CSK4	Pam3CSK4	NNP
cord-003091-uvfppirt	159	24	,	,	,
cord-003091-uvfppirt	159	25	and	and	CC
cord-003091-uvfppirt	159	26	Poly(I	Poly(I	NNP
cord-003091-uvfppirt	159	27	:	:	:
cord-003091-uvfppirt	159	28	C	C	NNP
cord-003091-uvfppirt	159	29	)	)	-RRB-
cord-003091-uvfppirt	159	30	and	and	CC
cord-003091-uvfppirt	159	31	coated	coat	VBN
cord-003091-uvfppirt	159	32	with	with	IN
cord-003091-uvfppirt	159	33	an	an	DT
cord-003091-uvfppirt	159	34	agonistic	agonistic	JJ
cord-003091-uvfppirt	159	35	αCD40-monoclonal	αcd40-monoclonal	JJ
cord-003091-uvfppirt	159	36	Ab	ab	NN
cord-003091-uvfppirt	159	37	(	(	-LRB-
cord-003091-uvfppirt	159	38	NP	NP	NNP
cord-003091-uvfppirt	159	39	-	-	HYPH
cord-003091-uvfppirt	159	40	CD40	CD40	NNP
cord-003091-uvfppirt	159	41	)	)	-RRB-
cord-003091-uvfppirt	159	42	.	.	.
cord-003091-uvfppirt	160	1	This	this	DT
cord-003091-uvfppirt	160	2	multi	multi	JJ
cord-003091-uvfppirt	160	3	-	-	JJ
cord-003091-uvfppirt	160	4	functional	functional	JJ
cord-003091-uvfppirt	160	5	strategy	strategy	NN
cord-003091-uvfppirt	160	6	resulted	result	VBD
cord-003091-uvfppirt	160	7	in	in	IN
cord-003091-uvfppirt	160	8	efficient	efficient	JJ
cord-003091-uvfppirt	160	9	and	and	CC
cord-003091-uvfppirt	160	10	selective	selective	JJ
cord-003091-uvfppirt	160	11	delivery	delivery	NN
cord-003091-uvfppirt	160	12	of	of	IN
cord-003091-uvfppirt	160	13	NPs	NPs	NNPS
cord-003091-uvfppirt	160	14	to	to	IN
cord-003091-uvfppirt	160	15	DCs	DCs	NNP
cord-003091-uvfppirt	160	16	in	in	IN
cord-003091-uvfppirt	160	17	vivo	vivo	NNP
cord-003091-uvfppirt	160	18	upon	upon	IN
cord-003091-uvfppirt	160	19	s.c	s.c	NNP
cord-003091-uvfppirt	160	20	.	.	NNP
cord-003091-uvfppirt	160	21	injection	injection	NN
cord-003091-uvfppirt	160	22	and	and	CC
cord-003091-uvfppirt	160	23	induced	induce	VBN
cord-003091-uvfppirt	160	24	priming	priming	NN
cord-003091-uvfppirt	160	25	of	of	IN
cord-003091-uvfppirt	160	26	CD8	CD8	NNP
cord-003091-uvfppirt	160	27	+	+	CC
cord-003091-uvfppirt	160	28	T	T	NNP
cord-003091-uvfppirt	160	29	cells	cell	NNS
cord-003091-uvfppirt	160	30	against	against	IN
cord-003091-uvfppirt	160	31	tumor	tumor	NN
cord-003091-uvfppirt	160	32	associated	associate	VBN
cord-003091-uvfppirt	160	33	ags	ags	NNP
cord-003091-uvfppirt	160	34	,	,	,
cord-003091-uvfppirt	160	35	increasing	increase	VBG
cord-003091-uvfppirt	160	36	tumor	tumor	NN
cord-003091-uvfppirt	160	37	-	-	HYPH
cord-003091-uvfppirt	160	38	bearing	bear	VBG
cord-003091-uvfppirt	160	39	mice	mice	NN
cord-003091-uvfppirt	160	40	survival	survival	NN
cord-003091-uvfppirt	160	41	(	(	-LRB-
cord-003091-uvfppirt	160	42	109	109	CD
cord-003091-uvfppirt	160	43	)	)	-RRB-
cord-003091-uvfppirt	160	44	.	.	.
cord-003091-uvfppirt	161	1	PLGA	PLGA	NNP
cord-003091-uvfppirt	161	2	NPs	NPs	NNPS
cord-003091-uvfppirt	161	3	carrying	carry	VBG
cord-003091-uvfppirt	161	4	the	the	DT
cord-003091-uvfppirt	161	5	poorly	poorly	RB
cord-003091-uvfppirt	161	6	immunogenic	immunogenic	JJ
cord-003091-uvfppirt	161	7	melanoma	melanoma	NN
cord-003091-uvfppirt	161	8	-	-	HYPH
cord-003091-uvfppirt	161	9	derived	derive	VBN
cord-003091-uvfppirt	161	10	antigen	antigen	NN
cord-003091-uvfppirt	161	11	tyrosinase	tyrosinase	NN
cord-003091-uvfppirt	161	12	-	-	HYPH
cord-003091-uvfppirt	161	13	related	relate	VBN
cord-003091-uvfppirt	161	14	protein	protein	NN
cord-003091-uvfppirt	161	15	2	2	CD
cord-003091-uvfppirt	161	16	along	along	IN
cord-003091-uvfppirt	161	17	with	with	IN
cord-003091-uvfppirt	161	18	7-acyl	7-acyl	CD
cord-003091-uvfppirt	161	19	lipid	lipid	NN
cord-003091-uvfppirt	161	20	A	a	NN
cord-003091-uvfppirt	161	21	,	,	,
cord-003091-uvfppirt	161	22	manage	manage	VB
cord-003091-uvfppirt	161	23	in	in	IN
cord-003091-uvfppirt	161	24	breaking	break	VBG
cord-003091-uvfppirt	161	25	the	the	DT
cord-003091-uvfppirt	161	26	immunotolerance	immunotolerance	NN
cord-003091-uvfppirt	161	27	acting	act	VBG
cord-003091-uvfppirt	161	28	against	against	IN
cord-003091-uvfppirt	161	29	tumor	tumor	NN
cord-003091-uvfppirt	161	30	-	-	HYPH
cord-003091-uvfppirt	161	31	antigens	antigen	NNS
cord-003091-uvfppirt	161	32	.	.	.
cord-003091-uvfppirt	162	1	Indeed	indeed	RB
cord-003091-uvfppirt	162	2	,	,	,
cord-003091-uvfppirt	162	3	administration	administration	NN
cord-003091-uvfppirt	162	4	of	of	IN
cord-003091-uvfppirt	162	5	the	the	DT
cord-003091-uvfppirt	162	6	abovementioned	abovementioned	JJ
cord-003091-uvfppirt	162	7	NPs	NPs	NNPS
cord-003091-uvfppirt	162	8	resulted	result	VBD
cord-003091-uvfppirt	162	9	in	in	IN
cord-003091-uvfppirt	162	10	antigen	antigen	NN
cord-003091-uvfppirt	162	11	-	-	HYPH
cord-003091-uvfppirt	162	12	specific	specific	JJ
cord-003091-uvfppirt	162	13	CD8	CD8	NNP
cord-003091-uvfppirt	162	14	+	+	SYM
cord-003091-uvfppirt	162	15	CTL	CTL	NNP
cord-003091-uvfppirt	162	16	responses	response	NNS
cord-003091-uvfppirt	162	17	,	,	,
cord-003091-uvfppirt	162	18	characterized	characterize	VBN
cord-003091-uvfppirt	162	19	by	by	IN
cord-003091-uvfppirt	162	20	IFN	IFN	NNP
cord-003091-uvfppirt	162	21	-	-	HYPH
cord-003091-uvfppirt	162	22	γ	γ	NNP
cord-003091-uvfppirt	162	23	production	production	NN
cord-003091-uvfppirt	162	24	and	and	CC
cord-003091-uvfppirt	162	25	increase	increase	NN
cord-003091-uvfppirt	162	26	of	of	IN
cord-003091-uvfppirt	162	27	pro	pro	JJ
cord-003091-uvfppirt	162	28	-	-	JJ
cord-003091-uvfppirt	162	29	inflammatory	inflammatory	JJ
cord-003091-uvfppirt	162	30	cytokines	cytokine	NNS
cord-003091-uvfppirt	162	31	in	in	IN
cord-003091-uvfppirt	162	32	the	the	DT
cord-003091-uvfppirt	162	33	tumor	tumor	NN
cord-003091-uvfppirt	162	34	microenvironment	microenvironment	NN
cord-003091-uvfppirt	162	35	(	(	-LRB-
cord-003091-uvfppirt	162	36	TME	TME	NNP
cord-003091-uvfppirt	162	37	)	)	-RRB-
cord-003091-uvfppirt	162	38	(	(	-LRB-
cord-003091-uvfppirt	162	39	59	59	CD
cord-003091-uvfppirt	162	40	)	)	-RRB-
cord-003091-uvfppirt	162	41	.	.	.
cord-003091-uvfppirt	163	1	Another	another	DT
cord-003091-uvfppirt	163	2	nano	nano	NN
cord-003091-uvfppirt	163	3	-	-	HYPH
cord-003091-uvfppirt	163	4	carrier	carrier	NN
cord-003091-uvfppirt	163	5	-	-	HYPH
cord-003091-uvfppirt	163	6	based	base	VBN
cord-003091-uvfppirt	163	7	approach	approach	NN
cord-003091-uvfppirt	163	8	relies	rely	VBZ
cord-003091-uvfppirt	163	9	on	on	IN
cord-003091-uvfppirt	163	10	liposome	liposome	NN
cord-003091-uvfppirt	163	11	,	,	,
cord-003091-uvfppirt	163	12	self	self	NN
cord-003091-uvfppirt	163	13	-	-	HYPH
cord-003091-uvfppirt	163	14	assembled	assemble	VBN
cord-003091-uvfppirt	163	15	vesicles	vesicle	NNS
cord-003091-uvfppirt	163	16	composed	compose	VBN
cord-003091-uvfppirt	163	17	by	by	IN
cord-003091-uvfppirt	163	18	lipid	lipid	NN
cord-003091-uvfppirt	163	19	bilayers	bilayer	NNS
cord-003091-uvfppirt	163	20	with	with	IN
cord-003091-uvfppirt	163	21	high	high	JJ
cord-003091-uvfppirt	163	22	functionalizing	functionalizing	NN
cord-003091-uvfppirt	163	23	properties	property	NNS
cord-003091-uvfppirt	163	24	.	.	.
cord-003091-uvfppirt	164	1	Besides	besides	RB
cord-003091-uvfppirt	164	2	,	,	,
cord-003091-uvfppirt	164	3	Maji	Maji	NNP
cord-003091-uvfppirt	164	4	and	and	CC
cord-003091-uvfppirt	164	5	colleagues	colleague	NNS
cord-003091-uvfppirt	164	6	reported	report	VBD
cord-003091-uvfppirt	164	7	that	that	IN
cord-003091-uvfppirt	164	8	after	after	IN
cord-003091-uvfppirt	164	9	uptake	uptake	NN
cord-003091-uvfppirt	164	10	by	by	IN
cord-003091-uvfppirt	164	11	DCs	DCs	NNP
cord-003091-uvfppirt	164	12	,	,	,
cord-003091-uvfppirt	164	13	cationic	cationic	NN
cord-003091-uvfppirt	164	14	liposomes	liposome	NNS
cord-003091-uvfppirt	164	15	localize	localize	VBP
cord-003091-uvfppirt	164	16	in	in	IN
cord-003091-uvfppirt	164	17	endosomal	endosomal	NNP
cord-003091-uvfppirt	164	18	compartments	compartment	NNS
cord-003091-uvfppirt	164	19	that	that	WDT
cord-003091-uvfppirt	164	20	allow	allow	VBP
cord-003091-uvfppirt	164	21	ag	ag	NNP
cord-003091-uvfppirt	164	22	presentation	presentation	NN
cord-003091-uvfppirt	164	23	preferentially	preferentially	RB
cord-003091-uvfppirt	164	24	on	on	IN
cord-003091-uvfppirt	164	25	MHC	MHC	NNP
cord-003091-uvfppirt	164	26	I	-PRON-	PRP
cord-003091-uvfppirt	164	27	but	but	CC
cord-003091-uvfppirt	164	28	do	do	VBP
cord-003091-uvfppirt	164	29	not	not	RB
cord-003091-uvfppirt	164	30	exclude	exclude	VB
cord-003091-uvfppirt	164	31	MHC	MHC	NNP
cord-003091-uvfppirt	164	32	II	II	NNP
cord-003091-uvfppirt	164	33	ag	ag	NNP
cord-003091-uvfppirt	164	34	presentation	presentation	NN
cord-003091-uvfppirt	164	35	(	(	-LRB-
cord-003091-uvfppirt	164	36	122	122	CD
cord-003091-uvfppirt	164	37	)	)	-RRB-
cord-003091-uvfppirt	164	38	,	,	,
cord-003091-uvfppirt	164	39	suggesting	suggest	VBG
cord-003091-uvfppirt	164	40	a	a	DT
cord-003091-uvfppirt	164	41	crucial	crucial	JJ
cord-003091-uvfppirt	164	42	role	role	NN
cord-003091-uvfppirt	164	43	in	in	IN
cord-003091-uvfppirt	164	44	antitumor	antitumor	JJ
cord-003091-uvfppirt	164	45	or	or	CC
cord-003091-uvfppirt	164	46	antiviral	antiviral	JJ
cord-003091-uvfppirt	164	47	immunity	immunity	NN
cord-003091-uvfppirt	164	48	supported	support	VBN
cord-003091-uvfppirt	164	49	by	by	IN
cord-003091-uvfppirt	164	50	Th	Th	NNP
cord-003091-uvfppirt	164	51	responses	response	NNS
cord-003091-uvfppirt	164	52	.	.	.
cord-003091-uvfppirt	165	1	In	in	IN
cord-003091-uvfppirt	165	2	addition	addition	NN
cord-003091-uvfppirt	165	3	to	to	IN
cord-003091-uvfppirt	165	4	the	the	DT
cord-003091-uvfppirt	165	5	use	use	NN
cord-003091-uvfppirt	165	6	of	of	IN
cord-003091-uvfppirt	165	7	NPs	NPs	NNP
cord-003091-uvfppirt	165	8	,	,	,
cord-003091-uvfppirt	165	9	targeting	target	VBG
cord-003091-uvfppirt	165	10	DC	DC	NNP
cord-003091-uvfppirt	165	11	-	-	HYPH
cord-003091-uvfppirt	165	12	specific	specific	JJ
cord-003091-uvfppirt	165	13	receptors	receptor	NNS
cord-003091-uvfppirt	165	14	has	have	VBZ
cord-003091-uvfppirt	165	15	become	become	VBN
cord-003091-uvfppirt	165	16	an	an	DT
cord-003091-uvfppirt	165	17	attractive	attractive	JJ
cord-003091-uvfppirt	165	18	strategy	strategy	NN
cord-003091-uvfppirt	165	19	for	for	IN
cord-003091-uvfppirt	165	20	vaccine	vaccine	NN
cord-003091-uvfppirt	165	21	development	development	NN
cord-003091-uvfppirt	165	22	due	due	IN
cord-003091-uvfppirt	165	23	to	to	IN
cord-003091-uvfppirt	165	24	the	the	DT
cord-003091-uvfppirt	165	25	enforced	enforce	VBN
cord-003091-uvfppirt	165	26	efficiency	efficiency	NN
cord-003091-uvfppirt	165	27	of	of	IN
cord-003091-uvfppirt	165	28	immune	immune	JJ
cord-003091-uvfppirt	165	29	responses	response	NNS
cord-003091-uvfppirt	165	30	when	when	WRB
cord-003091-uvfppirt	165	31	compared	compare	VBN
cord-003091-uvfppirt	165	32	to	to	IN
cord-003091-uvfppirt	165	33	generic	generic	RB
cord-003091-uvfppirt	165	34	-	-	HYPH
cord-003091-uvfppirt	165	35	delivering	deliver	VBG
cord-003091-uvfppirt	165	36	approaches	approach	NNS
cord-003091-uvfppirt	165	37	.	.	.
cord-003091-uvfppirt	166	1	Here	here	RB
cord-003091-uvfppirt	166	2	,	,	,
cord-003091-uvfppirt	166	3	we	-PRON-	PRP
cord-003091-uvfppirt	166	4	report	report	VBP
cord-003091-uvfppirt	166	5	the	the	DT
cord-003091-uvfppirt	166	6	more	more	RBR
cord-003091-uvfppirt	166	7	characterized	characterize	VBN
cord-003091-uvfppirt	166	8	DCs	DCs	NNP
cord-003091-uvfppirt	166	9	receptors	receptor	NNS
cord-003091-uvfppirt	166	10	,	,	,
cord-003091-uvfppirt	166	11	currently	currently	RB
cord-003091-uvfppirt	166	12	under	under	IN
cord-003091-uvfppirt	166	13	investigation	investigation	NN
cord-003091-uvfppirt	166	14	in	in	IN
cord-003091-uvfppirt	166	15	the	the	DT
cord-003091-uvfppirt	166	16	scenario	scenario	NN
cord-003091-uvfppirt	166	17	of	of	IN
cord-003091-uvfppirt	166	18	tailored	tailor	VBN
cord-003091-uvfppirt	166	19	-	-	HYPH
cord-003091-uvfppirt	166	20	vaccination	vaccination	NN
cord-003091-uvfppirt	166	21	,	,	,
cord-003091-uvfppirt	166	22	as	as	IN
cord-003091-uvfppirt	166	23	shown	show	VBN
cord-003091-uvfppirt	166	24	in	in	IN
cord-003091-uvfppirt	166	25	Table	Table	NNP
cord-003091-uvfppirt	166	26	1	1	CD
cord-003091-uvfppirt	166	27	.	.	.
cord-003091-uvfppirt	167	1	CLEC9A	CLEC9A	NNP
cord-003091-uvfppirt	167	2	or	or	CC
cord-003091-uvfppirt	167	3	DNGR1	dngr1	NN
cord-003091-uvfppirt	167	4	is	be	VBZ
cord-003091-uvfppirt	167	5	a	a	DT
cord-003091-uvfppirt	167	6	C	c	NN
cord-003091-uvfppirt	167	7	-	-	HYPH
cord-003091-uvfppirt	167	8	type	type	NN
cord-003091-uvfppirt	167	9	lectin	lectin	NN
cord-003091-uvfppirt	167	10	receptor	receptor	NN
cord-003091-uvfppirt	167	11	that	that	WDT
cord-003091-uvfppirt	167	12	mediates	mediate	VBZ
cord-003091-uvfppirt	167	13	endocytosis	endocytosis	NN
cord-003091-uvfppirt	167	14	,	,	,
cord-003091-uvfppirt	167	15	but	but	CC
cord-003091-uvfppirt	167	16	not	not	RB
cord-003091-uvfppirt	167	17	phagocytosis	phagocytosis	NN
cord-003091-uvfppirt	167	18	,	,	,
cord-003091-uvfppirt	167	19	with	with	IN
cord-003091-uvfppirt	167	20	low	low	JJ
cord-003091-uvfppirt	167	21	pH	ph	NN
cord-003091-uvfppirt	167	22	endosomes	endosome	NNS
cord-003091-uvfppirt	167	23	promoting	promote	VBG
cord-003091-uvfppirt	167	24	the	the	DT
cord-003091-uvfppirt	167	25	drift	drift	NN
cord-003091-uvfppirt	167	26	toward	toward	IN
cord-003091-uvfppirt	167	27	cross	cross	NN
cord-003091-uvfppirt	167	28	-	-	NN
cord-003091-uvfppirt	167	29	presentation	presentation	NN
cord-003091-uvfppirt	167	30	.	.	.
cord-003091-uvfppirt	168	1	Importantly	importantly	RB
cord-003091-uvfppirt	168	2	,	,	,
cord-003091-uvfppirt	168	3	CLEC9A	CLEC9A	NNP
cord-003091-uvfppirt	168	4	binding	binding	NN
cord-003091-uvfppirt	168	5	of	of	IN
cord-003091-uvfppirt	168	6	antigens	antigen	NNS
cord-003091-uvfppirt	168	7	induces	induce	VBZ
cord-003091-uvfppirt	168	8	antigen	antigen	NN
cord-003091-uvfppirt	168	9	presentation	presentation	NN
cord-003091-uvfppirt	168	10	on	on	IN
cord-003091-uvfppirt	168	11	both	both	CC
cord-003091-uvfppirt	168	12	MHC	MHC	NNP
cord-003091-uvfppirt	168	13	I	-PRON-	PRP
cord-003091-uvfppirt	168	14	(	(	-LRB-
cord-003091-uvfppirt	168	15	cross	cross	NN
cord-003091-uvfppirt	168	16	-	-	NN
cord-003091-uvfppirt	168	17	presentation	presentation	NN
cord-003091-uvfppirt	168	18	)	)	-RRB-
cord-003091-uvfppirt	168	19	and	and	CC
cord-003091-uvfppirt	168	20	MHC	MHC	NNP
cord-003091-uvfppirt	168	21	II	II	NNP
cord-003091-uvfppirt	168	22	.	.	.
cord-003091-uvfppirt	169	1	It	-PRON-	PRP
cord-003091-uvfppirt	169	2	is	be	VBZ
cord-003091-uvfppirt	169	3	highly	highly	RB
cord-003091-uvfppirt	169	4	and	and	CC
cord-003091-uvfppirt	169	5	specifically	specifically	RB
cord-003091-uvfppirt	169	6	expressed	express	VBN
cord-003091-uvfppirt	169	7	on	on	IN
cord-003091-uvfppirt	169	8	CD11c	CD11c	NNP
cord-003091-uvfppirt	170	1	+	+	CC
cord-003091-uvfppirt	171	1	CD141	CD141	NNP
cord-003091-uvfppirt	171	2	+	+	CC
cord-003091-uvfppirt	172	1	XCR1	XCR1	NNP
cord-003091-uvfppirt	172	2	+	+	CC
cord-003091-uvfppirt	173	1	cDCs	cDCs	NNP
cord-003091-uvfppirt	174	1	and	and	CC
cord-003091-uvfppirt	174	2	CD14	CD14	NNP
cord-003091-uvfppirt	174	3	+	+	CC
cord-003091-uvfppirt	175	1	CD16	CD16	NNP
cord-003091-uvfppirt	175	2	−	−	CD
cord-003091-uvfppirt	175	3	monocytes	monocyte	VBZ
cord-003091-uvfppirt	175	4	in	in	IN
cord-003091-uvfppirt	175	5	human	human	NN
cord-003091-uvfppirt	175	6	and	and	CC
cord-003091-uvfppirt	175	7	in	in	IN
cord-003091-uvfppirt	175	8	murine	murine	JJ
cord-003091-uvfppirt	175	9	pDCs	pdcs	NN
cord-003091-uvfppirt	175	10	and	and	CC
cord-003091-uvfppirt	175	11	XCR1	XCR1	NNP
cord-003091-uvfppirt	175	12	+	+	CC
cord-003091-uvfppirt	175	13	CD8a	CD8a	NNP
cord-003091-uvfppirt	175	14	+	+	CC
cord-003091-uvfppirt	175	15	LN	ln	NN
cord-003091-uvfppirt	175	16	resident	resident	NN
cord-003091-uvfppirt	175	17	but	but	CC
cord-003091-uvfppirt	176	1	not	not	RB
cord-003091-uvfppirt	176	2	CD103	cd103	VB
cord-003091-uvfppirt	176	3	+	+	SYM
cord-003091-uvfppirt	176	4	XCR1	XCR1	NNP
cord-003091-uvfppirt	176	5	+	+	SYM
cord-003091-uvfppirt	176	6	migrating	migrate	VBG
cord-003091-uvfppirt	176	7	DCs	DCs	NNP
cord-003091-uvfppirt	176	8	(	(	-LRB-
cord-003091-uvfppirt	176	9	123	123	CD
cord-003091-uvfppirt	176	10	,	,	,
cord-003091-uvfppirt	176	11	124	124	CD
cord-003091-uvfppirt	176	12	)	)	-RRB-
cord-003091-uvfppirt	176	13	.	.	.
cord-003091-uvfppirt	177	1	Indeed	indeed	RB
cord-003091-uvfppirt	177	2	,	,	,
cord-003091-uvfppirt	177	3	CD141	CD141	''
cord-003091-uvfppirt	177	4	+	+	CC
cord-003091-uvfppirt	178	1	XCR1	XCR1	NNP
cord-003091-uvfppirt	178	2	+	+	CC
cord-003091-uvfppirt	178	3	DCs	dc	NNS
cord-003091-uvfppirt	178	4	constitute	constitute	VBP
cord-003091-uvfppirt	178	5	the	the	DT
cord-003091-uvfppirt	178	6	human	human	JJ
cord-003091-uvfppirt	178	7	counterpart	counterpart	NN
cord-003091-uvfppirt	178	8	of	of	IN
cord-003091-uvfppirt	178	9	CD8α	CD8α	NNP
cord-003091-uvfppirt	178	10	+	+	CC
cord-003091-uvfppirt	178	11	XCR1	XCR1	NNP
cord-003091-uvfppirt	178	12	+	+	CC
cord-003091-uvfppirt	178	13	murine	murine	JJ
cord-003091-uvfppirt	178	14	DCs	dc	NNS
cord-003091-uvfppirt	178	15	(	(	-LRB-
cord-003091-uvfppirt	178	16	125	125	CD
cord-003091-uvfppirt	178	17	)	)	-RRB-
cord-003091-uvfppirt	178	18	.	.	.
cord-003091-uvfppirt	179	1	They	-PRON-	PRP
cord-003091-uvfppirt	179	2	share	share	VBP
cord-003091-uvfppirt	179	3	XCR1	XCR1	NNP
cord-003091-uvfppirt	179	4	,	,	,
cord-003091-uvfppirt	179	5	the	the	DT
cord-003091-uvfppirt	179	6	receptor	receptor	NN
cord-003091-uvfppirt	179	7	of	of	IN
cord-003091-uvfppirt	179	8	XCL1	XCL1	NNP
cord-003091-uvfppirt	179	9	.	.	.
cord-003091-uvfppirt	180	1	XCL1	XCL1	NNP
cord-003091-uvfppirt	180	2	is	be	VBZ
cord-003091-uvfppirt	180	3	released	release	VBN
cord-003091-uvfppirt	180	4	by	by	IN
cord-003091-uvfppirt	180	5	activated	activate	VBN
cord-003091-uvfppirt	180	6	T	T	NNP
cord-003091-uvfppirt	180	7	cells	cell	NNS
cord-003091-uvfppirt	180	8	and	and	CC
cord-003091-uvfppirt	180	9	the	the	DT
cord-003091-uvfppirt	180	10	axis	axis	NN
cord-003091-uvfppirt	180	11	XCR1-XCL1	XCR1-XCL1	NNP
cord-003091-uvfppirt	180	12	is	be	VBZ
cord-003091-uvfppirt	180	13	necessary	necessary	JJ
cord-003091-uvfppirt	180	14	for	for	IN
cord-003091-uvfppirt	180	15	robust	robust	JJ
cord-003091-uvfppirt	180	16	CTL	CTL	NNP
cord-003091-uvfppirt	180	17	responses	response	NNS
cord-003091-uvfppirt	180	18	(	(	-LRB-
cord-003091-uvfppirt	180	19	126	126	CD
cord-003091-uvfppirt	180	20	)	)	-RRB-
cord-003091-uvfppirt	180	21	.	.	.
cord-003091-uvfppirt	181	1	CD141	CD141	NNP
cord-003091-uvfppirt	181	2	+	+	CC
cord-003091-uvfppirt	182	1	XCR1	XCR1	NNP
cord-003091-uvfppirt	182	2	+	+	CC
cord-003091-uvfppirt	182	3	DCs	dc	NNS
cord-003091-uvfppirt	182	4	are	be	VBP
cord-003091-uvfppirt	182	5	the	the	DT
cord-003091-uvfppirt	182	6	main	main	JJ
cord-003091-uvfppirt	182	7	cross	cross	NN
cord-003091-uvfppirt	182	8	-	-	JJ
cord-003091-uvfppirt	182	9	presenting	presenting	JJ
cord-003091-uvfppirt	182	10	DCs	dc	NNS
cord-003091-uvfppirt	182	11	in	in	IN
cord-003091-uvfppirt	182	12	human	human	NN
cord-003091-uvfppirt	182	13	,	,	,
cord-003091-uvfppirt	182	14	thus	thus	RB
cord-003091-uvfppirt	182	15	they	-PRON-	PRP
cord-003091-uvfppirt	182	16	appear	appear	VBP
cord-003091-uvfppirt	182	17	promising	promise	VBG
cord-003091-uvfppirt	182	18	for	for	IN
cord-003091-uvfppirt	182	19	CTL	CTL	NNP
cord-003091-uvfppirt	182	20	-	-	HYPH
cord-003091-uvfppirt	182	21	mediated	mediate	VBN
cord-003091-uvfppirt	182	22	responses	response	NNS
cord-003091-uvfppirt	182	23	,	,	,
cord-003091-uvfppirt	182	24	in	in	IN
cord-003091-uvfppirt	182	25	tumors	tumor	NNS
cord-003091-uvfppirt	182	26	and	and	CC
cord-003091-uvfppirt	182	27	viral	viral	JJ
cord-003091-uvfppirt	182	28	infections	infection	NNS
cord-003091-uvfppirt	182	29	(	(	-LRB-
cord-003091-uvfppirt	182	30	127	127	CD
cord-003091-uvfppirt	182	31	)	)	-RRB-
cord-003091-uvfppirt	182	32	.	.	.
cord-003091-uvfppirt	183	1	This	this	DT
cord-003091-uvfppirt	183	2	specific	specific	JJ
cord-003091-uvfppirt	183	3	subset	subset	NN
cord-003091-uvfppirt	183	4	is	be	VBZ
cord-003091-uvfppirt	183	5	characterized	characterize	VBN
cord-003091-uvfppirt	183	6	by	by	IN
cord-003091-uvfppirt	183	7	the	the	DT
cord-003091-uvfppirt	183	8	expression	expression	NN
cord-003091-uvfppirt	183	9	of	of	IN
cord-003091-uvfppirt	183	10	TLR3	TLR3	NNP
cord-003091-uvfppirt	183	11	that	that	WDT
cord-003091-uvfppirt	183	12	may	may	MD
cord-003091-uvfppirt	183	13	be	be	VB
cord-003091-uvfppirt	183	14	exploited	exploit	VBN
cord-003091-uvfppirt	183	15	to	to	TO
cord-003091-uvfppirt	183	16	fully	fully	RB
cord-003091-uvfppirt	183	17	activate	activate	VB
cord-003091-uvfppirt	183	18	CLEC9A	CLEC9A	NNP
cord-003091-uvfppirt	183	19	+	+	SYM
cord-003091-uvfppirt	183	20	XCR1	XCR1	NNP
cord-003091-uvfppirt	183	21	+	+	CC
cord-003091-uvfppirt	183	22	DCs	dc	NNS
cord-003091-uvfppirt	183	23	since	since	IN
cord-003091-uvfppirt	183	24	antibody	antibody	NN
cord-003091-uvfppirt	183	25	binding	binding	NN
cord-003091-uvfppirt	183	26	of	of	IN
cord-003091-uvfppirt	183	27	CLEC9A	CLEC9A	NNP
cord-003091-uvfppirt	183	28	leads	lead	VBZ
cord-003091-uvfppirt	183	29	to	to	IN
cord-003091-uvfppirt	183	30	its	-PRON-	PRP$
cord-003091-uvfppirt	183	31	rapid	rapid	JJ
cord-003091-uvfppirt	183	32	internalization	internalization	NN
cord-003091-uvfppirt	183	33	but	but	CC
cord-003091-uvfppirt	183	34	not	not	RB
cord-003091-uvfppirt	183	35	TLR	tlr	NN
cord-003091-uvfppirt	183	36	-	-	HYPH
cord-003091-uvfppirt	183	37	pathway	pathway	NN
cord-003091-uvfppirt	183	38	activation	activation	NN
cord-003091-uvfppirt	183	39	,	,	,
cord-003091-uvfppirt	183	40	preventing	prevent	VBG
cord-003091-uvfppirt	183	41	pro	pro	JJ
cord-003091-uvfppirt	183	42	-	-	JJ
cord-003091-uvfppirt	183	43	inflammatory	inflammatory	JJ
cord-003091-uvfppirt	183	44	cytokine	cytokine	NN
cord-003091-uvfppirt	183	45	production	production	NN
cord-003091-uvfppirt	183	46	and	and	CC
cord-003091-uvfppirt	183	47	full	full	JJ
cord-003091-uvfppirt	183	48	maturation	maturation	NN
cord-003091-uvfppirt	183	49	of	of	IN
cord-003091-uvfppirt	183	50	DCs	DCs	NNP
cord-003091-uvfppirt	183	51	(	(	-LRB-
cord-003091-uvfppirt	183	52	127	127	CD
cord-003091-uvfppirt	183	53	)	)	-RRB-
cord-003091-uvfppirt	183	54	.	.	.
cord-003091-uvfppirt	184	1	Conversely	conversely	RB
cord-003091-uvfppirt	184	2	,	,	,
cord-003091-uvfppirt	184	3	Caminschi	Caminschi	NNP
cord-003091-uvfppirt	184	4	and	and	CC
cord-003091-uvfppirt	184	5	Li	Li	NNP
cord-003091-uvfppirt	184	6	independently	independently	RB
cord-003091-uvfppirt	184	7	demonstrated	demonstrate	VBD
cord-003091-uvfppirt	184	8	the	the	DT
cord-003091-uvfppirt	184	9	potentiality	potentiality	NN
cord-003091-uvfppirt	184	10	of	of	IN
cord-003091-uvfppirt	184	11	targeting	target	VBG
cord-003091-uvfppirt	184	12	Clec9A	Clec9A	NNP
cord-003091-uvfppirt	184	13	that	that	WDT
cord-003091-uvfppirt	184	14	resulted	result	VBD
cord-003091-uvfppirt	184	15	in	in	IN
cord-003091-uvfppirt	184	16	enhanced	enhance	VBN
cord-003091-uvfppirt	184	17	humoral	humoral	JJ
cord-003091-uvfppirt	184	18	immunity	immunity	NN
cord-003091-uvfppirt	184	19	independently	independently	RB
cord-003091-uvfppirt	184	20	of	of	IN
cord-003091-uvfppirt	184	21	TRIF	TRIF	NNP
cord-003091-uvfppirt	184	22	-	-	HYPH
cord-003091-uvfppirt	184	23	MyD88	MyD88	NNP
cord-003091-uvfppirt	184	24	or	or	CC
cord-003091-uvfppirt	184	25	TLR4	TLR4	NNP
cord-003091-uvfppirt	184	26	pathway	pathway	NN
cord-003091-uvfppirt	184	27	,	,	,
cord-003091-uvfppirt	184	28	even	even	RB
cord-003091-uvfppirt	184	29	in	in	IN
cord-003091-uvfppirt	184	30	the	the	DT
cord-003091-uvfppirt	184	31	absence	absence	NN
cord-003091-uvfppirt	184	32	of	of	IN
cord-003091-uvfppirt	184	33	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	184	34	(	(	-LRB-
cord-003091-uvfppirt	184	35	128	128	CD
cord-003091-uvfppirt	184	36	,	,	,
cord-003091-uvfppirt	184	37	129	129	CD
cord-003091-uvfppirt	184	38	)	)	-RRB-
cord-003091-uvfppirt	184	39	.	.	.
cord-003091-uvfppirt	185	1	Targeting	target	VBG
cord-003091-uvfppirt	185	2	Clec9A	Clec9A	NNP
cord-003091-uvfppirt	185	3	induces	induce	VBZ
cord-003091-uvfppirt	185	4	enhanced	enhance	VBN
cord-003091-uvfppirt	185	5	CD4	CD4	NNP
cord-003091-uvfppirt	185	6	+	+	CC
cord-003091-uvfppirt	185	7	T	t	NN
cord-003091-uvfppirt	185	8	cell	cell	NN
cord-003091-uvfppirt	185	9	proliferation	proliferation	NN
cord-003091-uvfppirt	185	10	in	in	IN
cord-003091-uvfppirt	185	11	vivo	vivo	NN
cord-003091-uvfppirt	185	12	,	,	,
cord-003091-uvfppirt	185	13	which	which	WDT
cord-003091-uvfppirt	185	14	supports	support	VBZ
cord-003091-uvfppirt	185	15	B	b	NN
cord-003091-uvfppirt	185	16	cell	cell	NN
cord-003091-uvfppirt	185	17	immunity	immunity	NN
cord-003091-uvfppirt	185	18	,	,	,
cord-003091-uvfppirt	185	19	when	when	WRB
cord-003091-uvfppirt	185	20	compared	compare	VBN
cord-003091-uvfppirt	185	21	to	to	IN
cord-003091-uvfppirt	185	22	the	the	DT
cord-003091-uvfppirt	185	23	targeting	targeting	NN
cord-003091-uvfppirt	185	24	of	of	IN
cord-003091-uvfppirt	185	25	another	another	DT
cord-003091-uvfppirt	185	26	endocytic	endocytic	JJ
cord-003091-uvfppirt	185	27	receptor	receptor	NN
cord-003091-uvfppirt	185	28	,	,	,
cord-003091-uvfppirt	185	29	discussed	discuss	VBN
cord-003091-uvfppirt	185	30	later	later	RB
cord-003091-uvfppirt	185	31	,	,	,
cord-003091-uvfppirt	185	32	DEC-205	dec-205	UH
cord-003091-uvfppirt	185	33	,	,	,
cord-003091-uvfppirt	185	34	independently	independently	RB
cord-003091-uvfppirt	185	35	of	of	IN
cord-003091-uvfppirt	185	36	the	the	DT
cord-003091-uvfppirt	185	37	use	use	NN
cord-003091-uvfppirt	185	38	of	of	IN
cord-003091-uvfppirt	185	39	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	185	40	as	as	IN
cord-003091-uvfppirt	185	41	CpG	CpG	NNP
cord-003091-uvfppirt	185	42	(	(	-LRB-
cord-003091-uvfppirt	185	43	130	130	CD
cord-003091-uvfppirt	185	44	)	)	-RRB-
cord-003091-uvfppirt	185	45	.	.	.
cord-003091-uvfppirt	186	1	Some	some	DT
cord-003091-uvfppirt	186	2	years	year	NNS
cord-003091-uvfppirt	186	3	later	later	RB
cord-003091-uvfppirt	186	4	,	,	,
cord-003091-uvfppirt	186	5	different	different	JJ
cord-003091-uvfppirt	186	6	authors	author	NNS
cord-003091-uvfppirt	186	7	demonstrated	demonstrate	VBD
cord-003091-uvfppirt	186	8	that	that	IN
cord-003091-uvfppirt	186	9	this	this	DT
cord-003091-uvfppirt	186	10	strong	strong	JJ
cord-003091-uvfppirt	186	11	humoral	humoral	JJ
cord-003091-uvfppirt	186	12	response	response	NN
cord-003091-uvfppirt	186	13	is	be	VBZ
cord-003091-uvfppirt	186	14	endorsed	endorse	VBN
cord-003091-uvfppirt	186	15	by	by	IN
cord-003091-uvfppirt	186	16	the	the	DT
cord-003091-uvfppirt	186	17	establishment	establishment	NN
cord-003091-uvfppirt	186	18	of	of	IN
cord-003091-uvfppirt	186	19	follicular	follicular	JJ
cord-003091-uvfppirt	186	20	T	T	NNP
cord-003091-uvfppirt	186	21	helper	helper	NN
cord-003091-uvfppirt	186	22	cells	cell	NNS
cord-003091-uvfppirt	186	23	memory	memory	NN
cord-003091-uvfppirt	186	24	,	,	,
cord-003091-uvfppirt	186	25	even	even	RB
cord-003091-uvfppirt	186	26	upon	upon	IN
cord-003091-uvfppirt	186	27	vaccination	vaccination	NN
cord-003091-uvfppirt	186	28	with	with	IN
cord-003091-uvfppirt	186	29	glycoprotein	glycoprotein	NN
cord-003091-uvfppirt	186	30	D	d	NN
cord-003091-uvfppirt	186	31	of	of	IN
cord-003091-uvfppirt	186	32	HSV	HSV	NNP
cord-003091-uvfppirt	186	33	,	,	,
cord-003091-uvfppirt	186	34	both	both	CC
cord-003091-uvfppirt	186	35	in	in	IN
cord-003091-uvfppirt	186	36	mice	mouse	NNS
cord-003091-uvfppirt	186	37	and	and	CC
cord-003091-uvfppirt	186	38	non	non	JJ
cord-003091-uvfppirt	186	39	-	-	JJ
cord-003091-uvfppirt	186	40	human	human	JJ
cord-003091-uvfppirt	186	41	primates	primate	NNS
cord-003091-uvfppirt	186	42	(	(	-LRB-
cord-003091-uvfppirt	186	43	128	128	CD
cord-003091-uvfppirt	186	44	,	,	,
cord-003091-uvfppirt	186	45	131	131	CD
cord-003091-uvfppirt	186	46	,	,	,
cord-003091-uvfppirt	186	47	132	132	CD
cord-003091-uvfppirt	186	48	)	)	-RRB-
cord-003091-uvfppirt	186	49	.	.	.
cord-003091-uvfppirt	187	1	These	these	DT
cord-003091-uvfppirt	187	2	promising	promising	JJ
cord-003091-uvfppirt	187	3	results	result	NNS
cord-003091-uvfppirt	187	4	were	be	VBD
cord-003091-uvfppirt	187	5	confirmed	confirm	VBN
cord-003091-uvfppirt	187	6	also	also	RB
cord-003091-uvfppirt	187	7	in	in	IN
cord-003091-uvfppirt	187	8	a	a	DT
cord-003091-uvfppirt	187	9	human	human	NN
cord-003091-uvfppirt	187	10	in	in	IN
cord-003091-uvfppirt	187	11	vitro	vitro	FW
cord-003091-uvfppirt	187	12	setting	set	VBG
cord-003091-uvfppirt	187	13	,	,	,
cord-003091-uvfppirt	187	14	on	on	IN
cord-003091-uvfppirt	187	15	CD141	CD141	NNP
cord-003091-uvfppirt	187	16	+	+	CC
cord-003091-uvfppirt	187	17	DCs	DCs	NNP
cord-003091-uvfppirt	187	18	(	(	-LRB-
cord-003091-uvfppirt	187	19	133	133	CD
cord-003091-uvfppirt	187	20	)	)	-RRB-
cord-003091-uvfppirt	187	21	.	.	.
cord-003091-uvfppirt	188	1	Finally	finally	RB
cord-003091-uvfppirt	188	2	,	,	,
cord-003091-uvfppirt	188	3	the	the	DT
cord-003091-uvfppirt	188	4	efficacy	efficacy	NN
cord-003091-uvfppirt	188	5	of	of	IN
cord-003091-uvfppirt	188	6	targeting	target	VBG
cord-003091-uvfppirt	188	7	Clec9A	Clec9A	NNP
cord-003091-uvfppirt	188	8	has	have	VBZ
cord-003091-uvfppirt	188	9	been	be	VBN
cord-003091-uvfppirt	188	10	evaluated	evaluate	VBN
cord-003091-uvfppirt	188	11	in	in	IN
cord-003091-uvfppirt	188	12	the	the	DT
cord-003091-uvfppirt	188	13	delivery	delivery	NN
cord-003091-uvfppirt	188	14	of	of	IN
cord-003091-uvfppirt	188	15	poorly	poorly	RB
cord-003091-uvfppirt	188	16	immunogenic	immunogenic	JJ
cord-003091-uvfppirt	188	17	virus	virus	NN
cord-003091-uvfppirt	188	18	-	-	HYPH
cord-003091-uvfppirt	188	19	derived	derive	VBN
cord-003091-uvfppirt	188	20	antigens	antigen	NNS
cord-003091-uvfppirt	188	21	.	.	.
cord-003091-uvfppirt	189	1	Park	park	NN
cord-003091-uvfppirt	189	2	and	and	CC
cord-003091-uvfppirt	189	3	colleagues	colleague	NNS
cord-003091-uvfppirt	189	4	managed	manage	VBD
cord-003091-uvfppirt	189	5	in	in	IN
cord-003091-uvfppirt	189	6	conferring	confer	VBG
cord-003091-uvfppirt	189	7	specific	specific	JJ
cord-003091-uvfppirt	189	8	humoral	humoral	JJ
cord-003091-uvfppirt	189	9	response	response	NN
cord-003091-uvfppirt	189	10	,	,	,
cord-003091-uvfppirt	189	11	protective	protective	JJ
cord-003091-uvfppirt	189	12	upon	upon	IN
cord-003091-uvfppirt	189	13	reinfection	reinfection	NN
cord-003091-uvfppirt	189	14	(	(	-LRB-
cord-003091-uvfppirt	189	15	134	134	CD
cord-003091-uvfppirt	189	16	)	)	-RRB-
cord-003091-uvfppirt	189	17	.	.	.
cord-003091-uvfppirt	190	1	Thus	thus	RB
cord-003091-uvfppirt	190	2	,	,	,
cord-003091-uvfppirt	190	3	exploiting	exploit	VBG
cord-003091-uvfppirt	190	4	the	the	DT
cord-003091-uvfppirt	190	5	specific	specific	JJ
cord-003091-uvfppirt	190	6	expression	expression	NN
cord-003091-uvfppirt	190	7	of	of	IN
cord-003091-uvfppirt	190	8	this	this	DT
cord-003091-uvfppirt	190	9	receptor	receptor	NN
cord-003091-uvfppirt	190	10	on	on	IN
cord-003091-uvfppirt	190	11	the	the	DT
cord-003091-uvfppirt	190	12	most	most	RBS
cord-003091-uvfppirt	190	13	specialized	specialized	JJ
cord-003091-uvfppirt	190	14	DCs	dc	NNS
cord-003091-uvfppirt	190	15	in	in	IN
cord-003091-uvfppirt	190	16	cross	cross	JJ
cord-003091-uvfppirt	190	17	-	-	NN
cord-003091-uvfppirt	190	18	presentation	presentation	NN
cord-003091-uvfppirt	190	19	in	in	IN
cord-003091-uvfppirt	190	20	combination	combination	NN
cord-003091-uvfppirt	190	21	with	with	IN
cord-003091-uvfppirt	190	22	TLR3	TLR3	NNP
cord-003091-uvfppirt	190	23	ligands	ligand	NNS
cord-003091-uvfppirt	190	24	,	,	,
cord-003091-uvfppirt	190	25	will	will	MD
cord-003091-uvfppirt	190	26	enhance	enhance	VB
cord-003091-uvfppirt	190	27	antiviral	antiviral	JJ
cord-003091-uvfppirt	190	28	and	and	CC
cord-003091-uvfppirt	190	29	anticancer	anticancer	JJ
cord-003091-uvfppirt	190	30	responses	response	NNS
cord-003091-uvfppirt	190	31	(	(	-LRB-
cord-003091-uvfppirt	190	32	135	135	CD
cord-003091-uvfppirt	190	33	)	)	-RRB-
cord-003091-uvfppirt	190	34	,	,	,
cord-003091-uvfppirt	190	35	combined	combine	VBN
cord-003091-uvfppirt	190	36	with	with	IN
cord-003091-uvfppirt	190	37	robust	robust	JJ
cord-003091-uvfppirt	190	38	humoral	humoral	JJ
cord-003091-uvfppirt	190	39	immunity	immunity	NN
cord-003091-uvfppirt	190	40	.	.	.
cord-003091-uvfppirt	191	1	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	192	1	or	or	CC
cord-003091-uvfppirt	192	2	CD205	cd205	NN
cord-003091-uvfppirt	192	3	is	be	VBZ
cord-003091-uvfppirt	192	4	a	a	DT
cord-003091-uvfppirt	192	5	205	205	CD
cord-003091-uvfppirt	192	6	kDa	kDa	NNS
cord-003091-uvfppirt	192	7	endocytic	endocytic	JJ
cord-003091-uvfppirt	192	8	receptor	receptor	NN
cord-003091-uvfppirt	192	9	that	that	WDT
cord-003091-uvfppirt	192	10	has	have	VBZ
cord-003091-uvfppirt	192	11	a	a	DT
cord-003091-uvfppirt	192	12	cysteine	cysteine	JJ
cord-003091-uvfppirt	192	13	-	-	HYPH
cord-003091-uvfppirt	192	14	rich	rich	JJ
cord-003091-uvfppirt	192	15	domain	domain	NN
cord-003091-uvfppirt	192	16	,	,	,
cord-003091-uvfppirt	192	17	a	a	DT
cord-003091-uvfppirt	192	18	fibronectin	fibronectin	NN
cord-003091-uvfppirt	192	19	type	type	NN
cord-003091-uvfppirt	192	20	II	ii	CD
cord-003091-uvfppirt	192	21	domain	domain	NN
cord-003091-uvfppirt	192	22	,	,	,
cord-003091-uvfppirt	192	23	and	and	CC
cord-003091-uvfppirt	192	24	10	10	CD
cord-003091-uvfppirt	192	25	C	c	NN
cord-003091-uvfppirt	192	26	-	-	HYPH
cord-003091-uvfppirt	192	27	type	type	NN
cord-003091-uvfppirt	192	28	lectin	lectin	NN
cord-003091-uvfppirt	192	29	-	-	HYPH
cord-003091-uvfppirt	192	30	like	like	JJ
cord-003091-uvfppirt	192	31	domains	domain	NNS
cord-003091-uvfppirt	192	32	,	,	,
cord-003091-uvfppirt	192	33	as	as	RB
cord-003091-uvfppirt	192	34	well	well	RB
cord-003091-uvfppirt	192	35	as	as	IN
cord-003091-uvfppirt	192	36	an	an	DT
cord-003091-uvfppirt	192	37	internalization	internalization	NN
cord-003091-uvfppirt	192	38	sequence	sequence	NN
cord-003091-uvfppirt	192	39	in	in	IN
cord-003091-uvfppirt	192	40	its	-PRON-	PRP$
cord-003091-uvfppirt	192	41	cytoplasmic	cytoplasmic	JJ
cord-003091-uvfppirt	192	42	tail	tail	NN
cord-003091-uvfppirt	192	43	(	(	-LRB-
cord-003091-uvfppirt	192	44	136	136	CD
cord-003091-uvfppirt	192	45	)	)	-RRB-
cord-003091-uvfppirt	192	46	.	.	.
cord-003091-uvfppirt	193	1	Thus	thus	RB
cord-003091-uvfppirt	193	2	,	,	,
cord-003091-uvfppirt	193	3	it	-PRON-	PRP
cord-003091-uvfppirt	193	4	mediates	mediate	VBZ
cord-003091-uvfppirt	193	5	cross	cross	JJ
cord-003091-uvfppirt	193	6	-	-	JJ
cord-003091-uvfppirt	193	7	presentation	presentation	NN
cord-003091-uvfppirt	193	8	through	through	IN
cord-003091-uvfppirt	193	9	clathrin	clathrin	NN
cord-003091-uvfppirt	193	10	-	-	:
cord-003091-uvfppirt	193	11	and	and	CC
cord-003091-uvfppirt	193	12	dynamin	dynamin	NN
cord-003091-uvfppirt	193	13	-	-	HYPH
cord-003091-uvfppirt	193	14	dependent	dependent	JJ
cord-003091-uvfppirt	193	15	receptor	receptor	NN
cord-003091-uvfppirt	193	16	-	-	HYPH
cord-003091-uvfppirt	193	17	mediated	mediate	VBN
cord-003091-uvfppirt	193	18	endocytosis	endocytosis	NN
cord-003091-uvfppirt	193	19	.	.	.
cord-003091-uvfppirt	194	1	Indeed	indeed	RB
cord-003091-uvfppirt	194	2	,	,	,
cord-003091-uvfppirt	194	3	it	-PRON-	PRP
cord-003091-uvfppirt	194	4	is	be	VBZ
cord-003091-uvfppirt	194	5	expressed	express	VBN
cord-003091-uvfppirt	194	6	by	by	IN
cord-003091-uvfppirt	194	7	the	the	DT
cord-003091-uvfppirt	194	8	most	most	RBS
cord-003091-uvfppirt	194	9	professional	professional	JJ
cord-003091-uvfppirt	194	10	cross	cross	NN
cord-003091-uvfppirt	194	11	-	-	JJ
cord-003091-uvfppirt	194	12	presenting	presenting	JJ
cord-003091-uvfppirt	194	13	DCs	dc	NNS
cord-003091-uvfppirt	194	14	,	,	,
cord-003091-uvfppirt	194	15	the	the	DT
cord-003091-uvfppirt	194	16	CD8α	CD8α	NNP
cord-003091-uvfppirt	194	17	+	+	CC
cord-003091-uvfppirt	194	18	DCs	DCs	NNP
cord-003091-uvfppirt	194	19	subtype	subtype	NN
cord-003091-uvfppirt	194	20	,	,	,
cord-003091-uvfppirt	194	21	while	while	IN
cord-003091-uvfppirt	194	22	CD8α	CD8α	NNP
cord-003091-uvfppirt	194	23	−	−	NNP
cord-003091-uvfppirt	194	24	DCs	dc	NNS
cord-003091-uvfppirt	194	25	display	display	NN
cord-003091-uvfppirt	194	26	very	very	RB
cord-003091-uvfppirt	194	27	low	low	JJ
cord-003091-uvfppirt	194	28	level	level	NN
cord-003091-uvfppirt	194	29	of	of	IN
cord-003091-uvfppirt	194	30	this	this	DT
cord-003091-uvfppirt	194	31	receptor	receptor	NN
cord-003091-uvfppirt	194	32	.	.	.
cord-003091-uvfppirt	195	1	In	in	IN
cord-003091-uvfppirt	195	2	addition	addition	NN
cord-003091-uvfppirt	195	3	,	,	,
cord-003091-uvfppirt	195	4	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	195	5	is	be	VBZ
cord-003091-uvfppirt	195	6	found	find	VBN
cord-003091-uvfppirt	195	7	on	on	IN
cord-003091-uvfppirt	195	8	dermal	dermal	JJ
cord-003091-uvfppirt	195	9	/	/	SYM
cord-003091-uvfppirt	195	10	interstitial	interstitial	JJ
cord-003091-uvfppirt	195	11	DCs	DCs	NNP
cord-003091-uvfppirt	195	12	and	and	CC
cord-003091-uvfppirt	195	13	LCs	LCs	NNP
cord-003091-uvfppirt	195	14	(	(	-LRB-
cord-003091-uvfppirt	195	15	137	137	CD
cord-003091-uvfppirt	195	16	)	)	-RRB-
cord-003091-uvfppirt	195	17	,	,	,
cord-003091-uvfppirt	195	18	thus	thus	RB
cord-003091-uvfppirt	195	19	guaranteeing	guarantee	VBG
cord-003091-uvfppirt	195	20	ag	ag	NNP
cord-003091-uvfppirt	195	21	delivery	delivery	NN
cord-003091-uvfppirt	195	22	to	to	IN
cord-003091-uvfppirt	195	23	both	both	DT
cord-003091-uvfppirt	195	24	skin	skin	NN
cord-003091-uvfppirt	195	25	-	-	HYPH
cord-003091-uvfppirt	195	26	resident	resident	NN
cord-003091-uvfppirt	195	27	and	and	CC
cord-003091-uvfppirt	195	28	LN	ln	NN
cord-003091-uvfppirt	195	29	-	-	HYPH
cord-003091-uvfppirt	195	30	resident	resident	JJ
cord-003091-uvfppirt	195	31	professional	professional	JJ
cord-003091-uvfppirt	195	32	APCs	apc	NNS
cord-003091-uvfppirt	195	33	.	.	.
cord-003091-uvfppirt	196	1	In	in	IN
cord-003091-uvfppirt	196	2	humans	human	NNS
cord-003091-uvfppirt	196	3	,	,	,
cord-003091-uvfppirt	196	4	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	196	5	is	be	VBZ
cord-003091-uvfppirt	196	6	shared	share	VBN
cord-003091-uvfppirt	196	7	among	among	IN
cord-003091-uvfppirt	196	8	cDCs	cDCs	NNP
cord-003091-uvfppirt	196	9	,	,	,
cord-003091-uvfppirt	196	10	monocytes	monocyte	NNS
cord-003091-uvfppirt	196	11	,	,	,
cord-003091-uvfppirt	196	12	and	and	CC
cord-003091-uvfppirt	196	13	B	b	NN
cord-003091-uvfppirt	196	14	cells	cell	NNS
cord-003091-uvfppirt	196	15	,	,	,
cord-003091-uvfppirt	196	16	while	while	IN
cord-003091-uvfppirt	196	17	pDCs	pDCs	NNP
cord-003091-uvfppirt	196	18	,	,	,
cord-003091-uvfppirt	196	19	granulocytes	granulocyte	NNS
cord-003091-uvfppirt	196	20	,	,	,
cord-003091-uvfppirt	196	21	NK	NK	NNP
cord-003091-uvfppirt	196	22	cells	cell	NNS
cord-003091-uvfppirt	196	23	,	,	,
cord-003091-uvfppirt	196	24	and	and	CC
cord-003091-uvfppirt	196	25	T	T	NNP
cord-003091-uvfppirt	196	26	lymphocytes	lymphocyte	NNS
cord-003091-uvfppirt	196	27	express	express	VBP
cord-003091-uvfppirt	196	28	low	low	JJ
cord-003091-uvfppirt	196	29	levels	level	NNS
cord-003091-uvfppirt	196	30	of	of	IN
cord-003091-uvfppirt	196	31	this	this	DT
cord-003091-uvfppirt	196	32	receptor	receptor	NN
cord-003091-uvfppirt	196	33	(	(	-LRB-
cord-003091-uvfppirt	196	34	138	138	CD
cord-003091-uvfppirt	196	35	)	)	-RRB-
cord-003091-uvfppirt	196	36	.	.	.
cord-003091-uvfppirt	197	1	In	in	IN
cord-003091-uvfppirt	197	2	addition	addition	NN
cord-003091-uvfppirt	197	3	,	,	,
cord-003091-uvfppirt	197	4	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	197	5	regulates	regulate	VBZ
cord-003091-uvfppirt	197	6	molecule	molecule	NN
cord-003091-uvfppirt	197	7	recycling	recycling	NN
cord-003091-uvfppirt	197	8	through	through	IN
cord-003091-uvfppirt	197	9	late	late	JJ
cord-003091-uvfppirt	197	10	endosomes	endosome	NNS
cord-003091-uvfppirt	197	11	,	,	,
cord-003091-uvfppirt	197	12	promoting	promote	VBG
cord-003091-uvfppirt	197	13	also	also	RB
cord-003091-uvfppirt	197	14	MHC	MHC	NNP
cord-003091-uvfppirt	197	15	II	II	NNP
cord-003091-uvfppirt	197	16	presentation	presentation	NN
cord-003091-uvfppirt	197	17	to	to	IN
cord-003091-uvfppirt	197	18	CD4	CD4	NNP
cord-003091-uvfppirt	197	19	+	+	CC
cord-003091-uvfppirt	197	20	T	T	NNP
cord-003091-uvfppirt	197	21	cells	cell	NNS
cord-003091-uvfppirt	197	22	in	in	IN
cord-003091-uvfppirt	197	23	LCs	LCs	NNP
cord-003091-uvfppirt	197	24	(	(	-LRB-
cord-003091-uvfppirt	197	25	139	139	CD
cord-003091-uvfppirt	197	26	)	)	-RRB-
cord-003091-uvfppirt	197	27	.	.	.
cord-003091-uvfppirt	198	1	Steinman	Steinman	NNP
cord-003091-uvfppirt	198	2	and	and	CC
cord-003091-uvfppirt	198	3	Nussenzweig	Nussenzweig	NNP
cord-003091-uvfppirt	198	4	have	have	VBP
cord-003091-uvfppirt	198	5	addressed	address	VBN
cord-003091-uvfppirt	198	6	this	this	DT
cord-003091-uvfppirt	198	7	molecule	molecule	NN
cord-003091-uvfppirt	198	8	to	to	TO
cord-003091-uvfppirt	198	9	improve	improve	VB
cord-003091-uvfppirt	198	10	vaccine	vaccine	NN
cord-003091-uvfppirt	198	11	efficacy	efficacy	NN
cord-003091-uvfppirt	198	12	since	since	IN
cord-003091-uvfppirt	198	13	2000	2000	CD
cord-003091-uvfppirt	198	14	(	(	-LRB-
cord-003091-uvfppirt	198	15	140	140	CD
cord-003091-uvfppirt	198	16	)	)	-RRB-
cord-003091-uvfppirt	198	17	.	.	.
cord-003091-uvfppirt	199	1	By	by	IN
cord-003091-uvfppirt	199	2	taking	take	VBG
cord-003091-uvfppirt	199	3	advantage	advantage	NN
cord-003091-uvfppirt	199	4	of	of	IN
cord-003091-uvfppirt	199	5	anti	anti	JJ
cord-003091-uvfppirt	199	6	-	-	JJ
cord-003091-uvfppirt	199	7	DEC-205	dec-205	JJ
cord-003091-uvfppirt	199	8	rAb	rab	NN
cord-003091-uvfppirt	199	9	conjugated	conjugate	VBN
cord-003091-uvfppirt	199	10	to	to	IN
cord-003091-uvfppirt	199	11	OVA	OVA	NNP
cord-003091-uvfppirt	199	12	peptide	peptide	NN
cord-003091-uvfppirt	199	13	,	,	,
cord-003091-uvfppirt	199	14	they	-PRON-	PRP
cord-003091-uvfppirt	199	15	demonstrated	demonstrate	VBD
cord-003091-uvfppirt	199	16	that	that	IN
cord-003091-uvfppirt	199	17	s.c	s.c	NNP
cord-003091-uvfppirt	199	18	.	.	NNP
cord-003091-uvfppirt	199	19	injections	injection	NNS
cord-003091-uvfppirt	199	20	of	of	IN
cord-003091-uvfppirt	199	21	this	this	DT
cord-003091-uvfppirt	199	22	compound	compound	NN
cord-003091-uvfppirt	199	23	lead	lead	NN
cord-003091-uvfppirt	199	24	to	to	IN
cord-003091-uvfppirt	199	25	a	a	DT
cord-003091-uvfppirt	199	26	strong	strong	JJ
cord-003091-uvfppirt	199	27	IFN	IFN	NNP
cord-003091-uvfppirt	199	28	-	-	HYPH
cord-003091-uvfppirt	199	29	γ	γ	NN
cord-003091-uvfppirt	199	30	and	and	CC
cord-003091-uvfppirt	199	31	IL-2mediated	il-2mediate	VBN
cord-003091-uvfppirt	199	32	immunity	immunity	NN
cord-003091-uvfppirt	199	33	only	only	RB
cord-003091-uvfppirt	199	34	when	when	WRB
cord-003091-uvfppirt	199	35	DCs	DCs	NNP
cord-003091-uvfppirt	199	36	activation	activation	NN
cord-003091-uvfppirt	199	37	was	be	VBD
cord-003091-uvfppirt	199	38	supported	support	VBN
cord-003091-uvfppirt	199	39	by	by	IN
cord-003091-uvfppirt	199	40	αCD40	αCD40	NNP
cord-003091-uvfppirt	199	41	mAb	mAb	NNP
cord-003091-uvfppirt	199	42	,	,	,
cord-003091-uvfppirt	199	43	otherwise	otherwise	RB
cord-003091-uvfppirt	199	44	,	,	,
cord-003091-uvfppirt	199	45	tolerance	tolerance	NN
cord-003091-uvfppirt	199	46	against	against	IN
cord-003091-uvfppirt	199	47	the	the	DT
cord-003091-uvfppirt	199	48	OVA	OVA	NNP
cord-003091-uvfppirt	199	49	peptide	peptide	NN
cord-003091-uvfppirt	199	50	occurs	occur	VBZ
cord-003091-uvfppirt	199	51	(	(	-LRB-
cord-003091-uvfppirt	199	52	141	141	CD
cord-003091-uvfppirt	199	53	)	)	-RRB-
cord-003091-uvfppirt	199	54	.	.	.
cord-003091-uvfppirt	200	1	Indeed	indeed	RB
cord-003091-uvfppirt	200	2	,	,	,
cord-003091-uvfppirt	200	3	diversely	diversely	RB
cord-003091-uvfppirt	200	4	from	from	IN
cord-003091-uvfppirt	200	5	PRR	PRR	NNP
cord-003091-uvfppirt	200	6	agonists	agonist	NNS
cord-003091-uvfppirt	200	7	,	,	,
cord-003091-uvfppirt	200	8	antibody	antibody	NN
cord-003091-uvfppirt	200	9	crosslinking	crosslinking	NN
cord-003091-uvfppirt	201	1	the	the	DT
cord-003091-uvfppirt	201	2	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	201	3	does	do	VBZ
cord-003091-uvfppirt	201	4	not	not	RB
cord-003091-uvfppirt	201	5	induce	induce	VB
cord-003091-uvfppirt	201	6	DCs	DCs	NNP
cord-003091-uvfppirt	201	7	maturation	maturation	NN
cord-003091-uvfppirt	201	8	(	(	-LRB-
cord-003091-uvfppirt	201	9	142	142	CD
cord-003091-uvfppirt	201	10	)	)	-RRB-
cord-003091-uvfppirt	201	11	.	.	.
cord-003091-uvfppirt	202	1	Furthermore	furthermore	RB
cord-003091-uvfppirt	202	2	,	,	,
cord-003091-uvfppirt	202	3	few	few	JJ
cord-003091-uvfppirt	202	4	years	year	NNS
cord-003091-uvfppirt	202	5	later	later	RB
cord-003091-uvfppirt	202	6	,	,	,
cord-003091-uvfppirt	202	7	the	the	DT
cord-003091-uvfppirt	202	8	combined	combined	JJ
cord-003091-uvfppirt	202	9	strategy	strategy	NN
cord-003091-uvfppirt	202	10	of	of	IN
cord-003091-uvfppirt	202	11	anti	anti	JJ
cord-003091-uvfppirt	202	12	-	-	JJ
cord-003091-uvfppirt	202	13	DEC-205	dec-205	JJ
cord-003091-uvfppirt	202	14	and	and	CC
cord-003091-uvfppirt	202	15	αCD40	αCD40	NNP
cord-003091-uvfppirt	202	16	was	be	VBD
cord-003091-uvfppirt	202	17	reported	report	VBN
cord-003091-uvfppirt	202	18	to	to	TO
cord-003091-uvfppirt	202	19	confer	confer	VB
cord-003091-uvfppirt	202	20	protection	protection	NN
cord-003091-uvfppirt	202	21	against	against	IN
cord-003091-uvfppirt	202	22	melanoma	melanoma	NN
cord-003091-uvfppirt	202	23	and	and	CC
cord-003091-uvfppirt	202	24	intranasal	intranasal	NN
cord-003091-uvfppirt	202	25	influenza	influenza	NN
cord-003091-uvfppirt	202	26	infection	infection	NN
cord-003091-uvfppirt	202	27	(	(	-LRB-
cord-003091-uvfppirt	202	28	112	112	CD
cord-003091-uvfppirt	202	29	)	)	-RRB-
cord-003091-uvfppirt	202	30	.	.	.
cord-003091-uvfppirt	203	1	In	in	IN
cord-003091-uvfppirt	203	2	a	a	DT
cord-003091-uvfppirt	203	3	viral	viral	JJ
cord-003091-uvfppirt	203	4	setting	setting	NN
cord-003091-uvfppirt	203	5	,	,	,
cord-003091-uvfppirt	203	6	anti	anti	JJ
cord-003091-uvfppirt	203	7	-	-	JJ
cord-003091-uvfppirt	203	8	DEC-205	dec-205	JJ
cord-003091-uvfppirt	203	9	rAb	rab	NN
cord-003091-uvfppirt	203	10	chemically	chemically	RB
cord-003091-uvfppirt	203	11	coupled	couple	VBN
cord-003091-uvfppirt	203	12	with	with	IN
cord-003091-uvfppirt	203	13	HIV	HIV	NNP
cord-003091-uvfppirt	203	14	p24	p24	NN
cord-003091-uvfppirt	203	15	gag	gag	NN
cord-003091-uvfppirt	203	16	protein	protein	NN
cord-003091-uvfppirt	203	17	tested	test	VBN
cord-003091-uvfppirt	203	18	in	in	IN
cord-003091-uvfppirt	203	19	vitro	vitro	FW
cord-003091-uvfppirt	203	20	on	on	IN
cord-003091-uvfppirt	203	21	blood	blood	NN
cord-003091-uvfppirt	203	22	cells	cell	NNS
cord-003091-uvfppirt	203	23	derived	derive	VBN
cord-003091-uvfppirt	203	24	by	by	IN
cord-003091-uvfppirt	203	25	11	11	CD
cord-003091-uvfppirt	203	26	HIV	HIV	NNP
cord-003091-uvfppirt	203	27	-	-	HYPH
cord-003091-uvfppirt	203	28	infected	infect	VBN
cord-003091-uvfppirt	203	29	donors	donor	NNS
cord-003091-uvfppirt	203	30	has	have	VBZ
cord-003091-uvfppirt	203	31	revealed	reveal	VBN
cord-003091-uvfppirt	203	32	efficient	efficient	JJ
cord-003091-uvfppirt	203	33	expansion	expansion	NN
cord-003091-uvfppirt	203	34	of	of	IN
cord-003091-uvfppirt	203	35	IFN	IFN	NNP
cord-003091-uvfppirt	203	36	-	-	HYPH
cord-003091-uvfppirt	203	37	γ	γ	NNP
cord-003091-uvfppirt	203	38	-	-	HYPH
cord-003091-uvfppirt	203	39	producing	produce	VBG
cord-003091-uvfppirt	203	40	CD8	CD8	NNP
cord-003091-uvfppirt	203	41	+	+	CC
cord-003091-uvfppirt	203	42	T	t	NN
cord-003091-uvfppirt	203	43	lymphocytes	lymphocyte	NNS
cord-003091-uvfppirt	203	44	(	(	-LRB-
cord-003091-uvfppirt	203	45	143	143	CD
cord-003091-uvfppirt	203	46	)	)	-RRB-
cord-003091-uvfppirt	203	47	from	from	IN
cord-003091-uvfppirt	203	48	all	all	PDT
cord-003091-uvfppirt	203	49	the	the	DT
cord-003091-uvfppirt	203	50	different	different	JJ
cord-003091-uvfppirt	203	51	donors	donor	NNS
cord-003091-uvfppirt	203	52	.	.	.
cord-003091-uvfppirt	204	1	This	this	DT
cord-003091-uvfppirt	204	2	indicated	indicate	VBD
cord-003091-uvfppirt	204	3	that	that	IN
cord-003091-uvfppirt	204	4	DCs	DCs	NNP
cord-003091-uvfppirt	204	5	and	and	CC
cord-003091-uvfppirt	204	6	CD205	CD205	NNP
cord-003091-uvfppirt	204	7	can	can	MD
cord-003091-uvfppirt	204	8	lead	lead	VB
cord-003091-uvfppirt	204	9	to	to	IN
cord-003091-uvfppirt	204	10	the	the	DT
cord-003091-uvfppirt	204	11	generation	generation	NN
cord-003091-uvfppirt	204	12	of	of	IN
cord-003091-uvfppirt	204	13	different	different	JJ
cord-003091-uvfppirt	204	14	peptides	peptide	NNS
cord-003091-uvfppirt	204	15	from	from	IN
cord-003091-uvfppirt	204	16	a	a	DT
cord-003091-uvfppirt	204	17	single	single	JJ
cord-003091-uvfppirt	204	18	protein	protein	NN
cord-003091-uvfppirt	204	19	.	.	.
cord-003091-uvfppirt	205	1	Moreover	moreover	RB
cord-003091-uvfppirt	205	2	,	,	,
cord-003091-uvfppirt	205	3	vaccines	vaccine	NNS
cord-003091-uvfppirt	205	4	based	base	VBN
cord-003091-uvfppirt	205	5	on	on	IN
cord-003091-uvfppirt	205	6	the	the	DT
cord-003091-uvfppirt	205	7	filamentous	filamentous	JJ
cord-003091-uvfppirt	205	8	bacteriophage	bacteriophage	NN
cord-003091-uvfppirt	205	9	fd	fd	NNP
cord-003091-uvfppirt	205	10	presenting	present	VBG
cord-003091-uvfppirt	205	11	an	an	DT
cord-003091-uvfppirt	205	12	αDEC-205	αDEC-205	NNP
cord-003091-uvfppirt	205	13	scFv	scFv	NNS
cord-003091-uvfppirt	205	14	,	,	,
cord-003091-uvfppirt	205	15	efficiently	efficiently	RB
cord-003091-uvfppirt	205	16	induce	induce	VB
cord-003091-uvfppirt	205	17	DCs	DCs	NNP
cord-003091-uvfppirt	205	18	maturation	maturation	NN
cord-003091-uvfppirt	205	19	via	via	IN
cord-003091-uvfppirt	205	20	the	the	DT
cord-003091-uvfppirt	205	21	activation	activation	NN
cord-003091-uvfppirt	205	22	of	of	IN
cord-003091-uvfppirt	205	23	the	the	DT
cord-003091-uvfppirt	205	24	TLR9-MyD88	TLR9-MyD88	NNP
cord-003091-uvfppirt	205	25	pathway	pathway	NN
cord-003091-uvfppirt	205	26	(	(	-LRB-
cord-003091-uvfppirt	205	27	144	144	CD
cord-003091-uvfppirt	205	28	)	)	-RRB-
cord-003091-uvfppirt	205	29	,	,	,
cord-003091-uvfppirt	205	30	without	without	IN
cord-003091-uvfppirt	205	31	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	205	32	and	and	CC
cord-003091-uvfppirt	205	33	further	further	RB
cord-003091-uvfppirt	205	34	elicit	elicit	VB
cord-003091-uvfppirt	205	35	potent	potent	JJ
cord-003091-uvfppirt	205	36	antitumor	antitumor	JJ
cord-003091-uvfppirt	205	37	responses	response	NNS
cord-003091-uvfppirt	205	38	when	when	WRB
cord-003091-uvfppirt	205	39	compared	compare	VBN
cord-003091-uvfppirt	205	40	to	to	IN
cord-003091-uvfppirt	205	41	non	non	JJ
cord-003091-uvfppirt	205	42	-	-	JJ
cord-003091-uvfppirt	205	43	tailored	tailored	JJ
cord-003091-uvfppirt	205	44	ag	ag	NN
cord-003091-uvfppirt	205	45	delivery	delivery	NN
cord-003091-uvfppirt	205	46	(	(	-LRB-
cord-003091-uvfppirt	205	47	145	145	CD
cord-003091-uvfppirt	205	48	)	)	-RRB-
cord-003091-uvfppirt	205	49	.	.	.
cord-003091-uvfppirt	206	1	Intriguingly	intriguingly	RB
cord-003091-uvfppirt	206	2	,	,	,
cord-003091-uvfppirt	206	3	DEC-205	dec-205	UH
cord-003091-uvfppirt	206	4	,	,	,
cord-003091-uvfppirt	206	5	orphan	orphan	NN
cord-003091-uvfppirt	206	6	of	of	IN
cord-003091-uvfppirt	206	7	a	a	DT
cord-003091-uvfppirt	206	8	specific	specific	JJ
cord-003091-uvfppirt	206	9	ligand	ligand	NN
cord-003091-uvfppirt	206	10	,	,	,
cord-003091-uvfppirt	206	11	has	have	VBZ
cord-003091-uvfppirt	206	12	been	be	VBN
cord-003091-uvfppirt	206	13	proven	prove	VBN
cord-003091-uvfppirt	206	14	to	to	TO
cord-003091-uvfppirt	206	15	be	be	VB
cord-003091-uvfppirt	206	16	necessary	necessary	JJ
cord-003091-uvfppirt	206	17	for	for	IN
cord-003091-uvfppirt	206	18	CpG	CpG	NNP
cord-003091-uvfppirt	206	19	uptake	uptake	NNP
cord-003091-uvfppirt	206	20	and	and	CC
cord-003091-uvfppirt	206	21	eventual	eventual	JJ
cord-003091-uvfppirt	206	22	DC	DC	NNP
cord-003091-uvfppirt	206	23	activation	activation	NN
cord-003091-uvfppirt	206	24	(	(	-LRB-
cord-003091-uvfppirt	206	25	146	146	CD
cord-003091-uvfppirt	206	26	)	)	-RRB-
cord-003091-uvfppirt	206	27	.	.	.
cord-003091-uvfppirt	207	1	CD40	CD40	NNP
cord-003091-uvfppirt	207	2	is	be	VBZ
cord-003091-uvfppirt	207	3	a	a	DT
cord-003091-uvfppirt	207	4	molecule	molecule	NN
cord-003091-uvfppirt	207	5	belonging	belong	VBG
cord-003091-uvfppirt	207	6	to	to	IN
cord-003091-uvfppirt	207	7	the	the	DT
cord-003091-uvfppirt	207	8	TNF	TNF	NNP
cord-003091-uvfppirt	207	9	receptor	receptor	NN
cord-003091-uvfppirt	207	10	family	family	NN
cord-003091-uvfppirt	207	11	,	,	,
cord-003091-uvfppirt	207	12	expressed	express	VBN
cord-003091-uvfppirt	207	13	by	by	IN
cord-003091-uvfppirt	207	14	several	several	JJ
cord-003091-uvfppirt	207	15	cell	cell	NN
cord-003091-uvfppirt	207	16	types	type	NNS
cord-003091-uvfppirt	207	17	and	and	CC
cord-003091-uvfppirt	207	18	among	among	IN
cord-003091-uvfppirt	207	19	these	these	DT
cord-003091-uvfppirt	207	20	,	,	,
cord-003091-uvfppirt	207	21	DCs	DCs	NNP
cord-003091-uvfppirt	207	22	.	.	.
cord-003091-uvfppirt	208	1	It	-PRON-	PRP
cord-003091-uvfppirt	208	2	has	have	VBZ
cord-003091-uvfppirt	208	3	emerged	emerge	VBN
cord-003091-uvfppirt	208	4	as	as	IN
cord-003091-uvfppirt	208	5	a	a	DT
cord-003091-uvfppirt	208	6	receptor	receptor	NN
cord-003091-uvfppirt	208	7	for	for	IN
cord-003091-uvfppirt	208	8	the	the	DT
cord-003091-uvfppirt	208	9	human	human	JJ
cord-003091-uvfppirt	208	10	chaperone	chaperone	NN
cord-003091-uvfppirt	208	11	Heat	Heat	NNP
cord-003091-uvfppirt	208	12	shock	shock	NN
cord-003091-uvfppirt	208	13	protein	protein	NN
cord-003091-uvfppirt	208	14	(	(	-LRB-
cord-003091-uvfppirt	208	15	Hsp	Hsp	NNP
cord-003091-uvfppirt	208	16	)	)	-RRB-
cord-003091-uvfppirt	208	17	70	70	CD
cord-003091-uvfppirt	208	18	that	that	WDT
cord-003091-uvfppirt	208	19	mediates	mediate	VBZ
cord-003091-uvfppirt	208	20	the	the	DT
cord-003091-uvfppirt	208	21	internalization	internalization	NN
cord-003091-uvfppirt	208	22	of	of	IN
cord-003091-uvfppirt	208	23	peptides	peptide	NNS
cord-003091-uvfppirt	208	24	bound	bind	VBN
cord-003091-uvfppirt	208	25	to	to	IN
cord-003091-uvfppirt	208	26	Hsp70	Hsp70	NNP
cord-003091-uvfppirt	208	27	itself	-PRON-	PRP
cord-003091-uvfppirt	208	28	(	(	-LRB-
cord-003091-uvfppirt	208	29	147	147	CD
cord-003091-uvfppirt	208	30	)	)	-RRB-
cord-003091-uvfppirt	208	31	.	.	.
cord-003091-uvfppirt	209	1	Moreover	moreover	RB
cord-003091-uvfppirt	209	2	,	,	,
cord-003091-uvfppirt	209	3	upon	upon	IN
cord-003091-uvfppirt	209	4	activation	activation	NN
cord-003091-uvfppirt	209	5	,	,	,
cord-003091-uvfppirt	209	6	T	t	NN
cord-003091-uvfppirt	209	7	cell	cell	NN
cord-003091-uvfppirt	209	8	transiently	transiently	RB
cord-003091-uvfppirt	209	9	expresses	express	VBZ
cord-003091-uvfppirt	209	10	CD40L	cd40l	NN
cord-003091-uvfppirt	209	11	allowing	allow	VBG
cord-003091-uvfppirt	209	12	cross	cross	NN
cord-003091-uvfppirt	209	13	-	-	NN
cord-003091-uvfppirt	209	14	linking	linking	NN
cord-003091-uvfppirt	209	15	of	of	IN
cord-003091-uvfppirt	209	16	CD40	CD40	NNP
cord-003091-uvfppirt	209	17	on	on	IN
cord-003091-uvfppirt	209	18	DCs	DCs	NNP
cord-003091-uvfppirt	209	19	and	and	CC
cord-003091-uvfppirt	209	20	completing	complete	VBG
cord-003091-uvfppirt	209	21	their	-PRON-	PRP$
cord-003091-uvfppirt	209	22	maturation	maturation	NN
cord-003091-uvfppirt	209	23	.	.	.
cord-003091-uvfppirt	210	1	From	from	IN
cord-003091-uvfppirt	210	2	these	these	DT
cord-003091-uvfppirt	210	3	notions	notion	NNS
cord-003091-uvfppirt	210	4	,	,	,
cord-003091-uvfppirt	210	5	CD40	CD40	NNP
cord-003091-uvfppirt	210	6	appeared	appear	VBD
cord-003091-uvfppirt	210	7	an	an	DT
cord-003091-uvfppirt	210	8	interesting	interesting	JJ
cord-003091-uvfppirt	210	9	molecule	molecule	NN
cord-003091-uvfppirt	210	10	to	to	TO
cord-003091-uvfppirt	210	11	target	target	VB
cord-003091-uvfppirt	210	12	for	for	IN
cord-003091-uvfppirt	210	13	DC	DC	NNP
cord-003091-uvfppirt	210	14	-	-	HYPH
cord-003091-uvfppirt	210	15	based	base	VBN
cord-003091-uvfppirt	210	16	vaccination	vaccination	NN
cord-003091-uvfppirt	210	17	strategies	strategy	NNS
cord-003091-uvfppirt	210	18	.	.	.
cord-003091-uvfppirt	211	1	Indeed	indeed	RB
cord-003091-uvfppirt	211	2	,	,	,
cord-003091-uvfppirt	211	3	by	by	IN
cord-003091-uvfppirt	211	4	engineering	engineer	VBG
cord-003091-uvfppirt	211	5	antibody	antibody	NN
cord-003091-uvfppirt	211	6	chemical	chemical	NN
cord-003091-uvfppirt	211	7	structure	structure	NN
cord-003091-uvfppirt	211	8	,	,	,
cord-003091-uvfppirt	211	9	Schjetne	Schjetne	NNP
cord-003091-uvfppirt	211	10	and	and	CC
cord-003091-uvfppirt	211	11	colleagues	colleague	NNS
cord-003091-uvfppirt	211	12	demonstrated	demonstrate	VBD
cord-003091-uvfppirt	211	13	the	the	DT
cord-003091-uvfppirt	211	14	efficacy	efficacy	NN
cord-003091-uvfppirt	211	15	of	of	IN
cord-003091-uvfppirt	211	16	CD40	CD40	NNP
cord-003091-uvfppirt	211	17	engagement	engagement	NN
cord-003091-uvfppirt	211	18	conferring	confer	VBG
cord-003091-uvfppirt	211	19	protection	protection	NN
cord-003091-uvfppirt	211	20	against	against	IN
cord-003091-uvfppirt	211	21	myeloma	myeloma	NN
cord-003091-uvfppirt	211	22	-	-	HYPH
cord-003091-uvfppirt	211	23	and	and	CC
cord-003091-uvfppirt	211	24	lymphoma	lymphoma	NN
cord-003091-uvfppirt	211	25	-	-	HYPH
cord-003091-uvfppirt	211	26	derived	derive	VBN
cord-003091-uvfppirt	211	27	ags	ag	NNS
cord-003091-uvfppirt	211	28	(	(	-LRB-
cord-003091-uvfppirt	211	29	148	148	CD
cord-003091-uvfppirt	211	30	)	)	-RRB-
cord-003091-uvfppirt	211	31	.	.	.
cord-003091-uvfppirt	212	1	Moreover	moreover	RB
cord-003091-uvfppirt	212	2	,	,	,
cord-003091-uvfppirt	212	3	through	through	IN
cord-003091-uvfppirt	212	4	the	the	DT
cord-003091-uvfppirt	212	5	co	co	NN
cord-003091-uvfppirt	212	6	-	-	NN
cord-003091-uvfppirt	212	7	administration	administration	NN
cord-003091-uvfppirt	212	8	of	of	IN
cord-003091-uvfppirt	212	9	two	two	CD
cord-003091-uvfppirt	212	10	DNA	dna	NN
cord-003091-uvfppirt	212	11	-	-	HYPH
cord-003091-uvfppirt	212	12	based	base	VBN
cord-003091-uvfppirt	212	13	vaccines	vaccine	NNS
cord-003091-uvfppirt	212	14	encoding	encode	VBG
cord-003091-uvfppirt	212	15	either	either	CC
cord-003091-uvfppirt	212	16	CD40	CD40	NNP
cord-003091-uvfppirt	212	17	and	and	CC
cord-003091-uvfppirt	212	18	the	the	DT
cord-003091-uvfppirt	212	19	foot	foot	NN
cord-003091-uvfppirt	212	20	-	-	HYPH
cord-003091-uvfppirt	212	21	and	and	CC
cord-003091-uvfppirt	212	22	-	-	HYPH
cord-003091-uvfppirt	212	23	mouth	mouth	NN
cord-003091-uvfppirt	212	24	disease	disease	NN
cord-003091-uvfppirt	212	25	-	-	HYPH
cord-003091-uvfppirt	212	26	derived	derive	VBN
cord-003091-uvfppirt	212	27	ags	ags	NNP
cord-003091-uvfppirt	212	28	,	,	,
cord-003091-uvfppirt	212	29	the	the	DT
cord-003091-uvfppirt	212	30	transient	transient	JJ
cord-003091-uvfppirt	212	31	increase	increase	NN
cord-003091-uvfppirt	212	32	of	of	IN
cord-003091-uvfppirt	212	33	endogenous	endogenous	JJ
cord-003091-uvfppirt	212	34	αCD40	αCD40	NNP
cord-003091-uvfppirt	212	35	antibodies	antibody	NNS
cord-003091-uvfppirt	212	36	allows	allow	VBZ
cord-003091-uvfppirt	212	37	an	an	DT
cord-003091-uvfppirt	212	38	efficacious	efficacious	JJ
cord-003091-uvfppirt	212	39	DCs	dc	NNS
cord-003091-uvfppirt	212	40	activation	activation	NN
cord-003091-uvfppirt	212	41	and	and	CC
cord-003091-uvfppirt	212	42	an	an	DT
cord-003091-uvfppirt	212	43	efficient	efficient	JJ
cord-003091-uvfppirt	212	44	development	development	NN
cord-003091-uvfppirt	212	45	of	of	IN
cord-003091-uvfppirt	212	46	ag	ag	JJ
cord-003091-uvfppirt	212	47	-	-	HYPH
cord-003091-uvfppirt	212	48	specific	specific	JJ
cord-003091-uvfppirt	212	49	T	T	NNP
cord-003091-uvfppirt	212	50	cell	cell	NN
cord-003091-uvfppirt	212	51	immunity	immunity	NN
cord-003091-uvfppirt	212	52	,	,	,
cord-003091-uvfppirt	212	53	if	if	IN
cord-003091-uvfppirt	212	54	compared	compare	VBN
cord-003091-uvfppirt	212	55	to	to	IN
cord-003091-uvfppirt	212	56	the	the	DT
cord-003091-uvfppirt	212	57	administration	administration	NN
cord-003091-uvfppirt	212	58	of	of	IN
cord-003091-uvfppirt	212	59	DNA	DNA	NNP
cord-003091-uvfppirt	212	60	encoding	encoding	NN
cord-003091-uvfppirt	212	61	ags	ag	NNS
cord-003091-uvfppirt	212	62	alone	alone	JJ
cord-003091-uvfppirt	212	63	(	(	-LRB-
cord-003091-uvfppirt	212	64	149	149	CD
cord-003091-uvfppirt	212	65	)	)	-RRB-
cord-003091-uvfppirt	212	66	.	.	.
cord-003091-uvfppirt	213	1	Further	further	JJ
cord-003091-uvfppirt	213	2	promising	promising	JJ
cord-003091-uvfppirt	213	3	results	result	NNS
cord-003091-uvfppirt	213	4	have	have	VBP
cord-003091-uvfppirt	213	5	been	be	VBN
cord-003091-uvfppirt	213	6	obtained	obtain	VBN
cord-003091-uvfppirt	213	7	in	in	IN
cord-003091-uvfppirt	213	8	a	a	DT
cord-003091-uvfppirt	213	9	vaccine	vaccine	NN
cord-003091-uvfppirt	213	10	against	against	IN
cord-003091-uvfppirt	213	11	cyclin	cyclin	NN
cord-003091-uvfppirt	213	12	-	-	HYPH
cord-003091-uvfppirt	213	13	D1	d1	NN
cord-003091-uvfppirt	213	14	that	that	WDT
cord-003091-uvfppirt	213	15	is	be	VBZ
cord-003091-uvfppirt	213	16	overexpressed	overexpresse	VBN
cord-003091-uvfppirt	213	17	by	by	IN
cord-003091-uvfppirt	213	18	mantle	mantle	NN
cord-003091-uvfppirt	213	19	cell	cell	NN
cord-003091-uvfppirt	213	20	lymphoma	lymphoma	NN
cord-003091-uvfppirt	213	21	(	(	-LRB-
cord-003091-uvfppirt	213	22	MCL	MCL	NNP
cord-003091-uvfppirt	213	23	)	)	-RRB-
cord-003091-uvfppirt	213	24	.	.	.
cord-003091-uvfppirt	214	1	Thanks	thank	NNS
cord-003091-uvfppirt	214	2	to	to	IN
cord-003091-uvfppirt	214	3	algorithm	algorithm	NN
cord-003091-uvfppirt	214	4	analysis	analysis	NN
cord-003091-uvfppirt	214	5	,	,	,
cord-003091-uvfppirt	214	6	Chen	Chen	NNP
cord-003091-uvfppirt	214	7	and	and	CC
cord-003091-uvfppirt	214	8	colleagues	colleague	NNS
cord-003091-uvfppirt	214	9	identified	identify	VBD
cord-003091-uvfppirt	214	10	three	three	CD
cord-003091-uvfppirt	214	11	cyclin	cyclin	NN
cord-003091-uvfppirt	214	12	-	-	:
cord-003091-uvfppirt	214	13	D1-derived	d1-derive	VBN
cord-003091-uvfppirt	214	14	peptides	peptide	NNS
cord-003091-uvfppirt	214	15	that	that	WDT
cord-003091-uvfppirt	214	16	efficiently	efficiently	RB
cord-003091-uvfppirt	214	17	bind	bind	VBP
cord-003091-uvfppirt	214	18	to	to	IN
cord-003091-uvfppirt	214	19	MHC	MHC	NNP
cord-003091-uvfppirt	214	20	class	class	NN
cord-003091-uvfppirt	214	21	I	-PRON-	PRP
cord-003091-uvfppirt	214	22	of	of	IN
cord-003091-uvfppirt	214	23	DCs	DCs	NNP
cord-003091-uvfppirt	214	24	,	,	,
cord-003091-uvfppirt	214	25	potentially	potentially	RB
cord-003091-uvfppirt	214	26	overexpressed	overexpresse	VBN
cord-003091-uvfppirt	214	27	in	in	IN
cord-003091-uvfppirt	214	28	all	all	DT
cord-003091-uvfppirt	214	29	MCL	MCL	NNP
cord-003091-uvfppirt	214	30	patients	patient	NNS
cord-003091-uvfppirt	214	31	.	.	.
cord-003091-uvfppirt	215	1	By	by	IN
cord-003091-uvfppirt	215	2	generating	generate	VBG
cord-003091-uvfppirt	215	3	a	a	DT
cord-003091-uvfppirt	215	4	rAb	rab	JJ
cord-003091-uvfppirt	215	5	targeting	target	VBG
cord-003091-uvfppirt	215	6	CD40	CD40	NNP
cord-003091-uvfppirt	215	7	,	,	,
cord-003091-uvfppirt	215	8	they	-PRON-	PRP
cord-003091-uvfppirt	215	9	efficiently	efficiently	RB
cord-003091-uvfppirt	215	10	delivered	deliver	VBD
cord-003091-uvfppirt	215	11	these	these	DT
cord-003091-uvfppirt	215	12	tumor	tumor	NN
cord-003091-uvfppirt	215	13	associated	associate	VBD
cord-003091-uvfppirt	215	14	ags	ags	NNP
cord-003091-uvfppirt	215	15	to	to	IN
cord-003091-uvfppirt	215	16	DCs	DCs	NNP
cord-003091-uvfppirt	215	17	and	and	CC
cord-003091-uvfppirt	215	18	mounted	mount	VBD
cord-003091-uvfppirt	215	19	IFN	IFN	NNP
cord-003091-uvfppirt	215	20	-	-	HYPH
cord-003091-uvfppirt	215	21	γ	γ	NN
cord-003091-uvfppirt	215	22	-	-	HYPH
cord-003091-uvfppirt	215	23	specific	specific	JJ
cord-003091-uvfppirt	215	24	T	T	NNP
cord-003091-uvfppirt	215	25	cell	cell	NN
cord-003091-uvfppirt	215	26	responses	response	NNS
cord-003091-uvfppirt	215	27	in	in	IN
cord-003091-uvfppirt	215	28	patients	patient	NNS
cord-003091-uvfppirt	215	29	-	-	HYPH
cord-003091-uvfppirt	215	30	derived	derive	VBN
cord-003091-uvfppirt	215	31	peripheral	peripheral	JJ
cord-003091-uvfppirt	215	32	blood	blood	NN
cord-003091-uvfppirt	215	33	mononuclear	mononuclear	NN
cord-003091-uvfppirt	215	34	cells	cell	NNS
cord-003091-uvfppirt	215	35	(	(	-LRB-
cord-003091-uvfppirt	215	36	150	150	CD
cord-003091-uvfppirt	215	37	)	)	-RRB-
cord-003091-uvfppirt	215	38	.	.	.
cord-003091-uvfppirt	216	1	Thus	thus	RB
cord-003091-uvfppirt	216	2	,	,	,
cord-003091-uvfppirt	216	3	CD40	CD40	NNP
cord-003091-uvfppirt	216	4	represents	represent	VBZ
cord-003091-uvfppirt	216	5	a	a	DT
cord-003091-uvfppirt	216	6	specific	specific	JJ
cord-003091-uvfppirt	216	7	DC	DC	NNP
cord-003091-uvfppirt	216	8	-	-	HYPH
cord-003091-uvfppirt	216	9	targeting	target	VBG
cord-003091-uvfppirt	216	10	molecule	molecule	NN
cord-003091-uvfppirt	216	11	that	that	WDT
cord-003091-uvfppirt	216	12	has	have	VBZ
cord-003091-uvfppirt	216	13	been	be	VBN
cord-003091-uvfppirt	216	14	used	use	VBN
cord-003091-uvfppirt	216	15	in	in	IN
cord-003091-uvfppirt	216	16	combination	combination	NN
cord-003091-uvfppirt	216	17	with	with	IN
cord-003091-uvfppirt	216	18	other	other	JJ
cord-003091-uvfppirt	216	19	targeting	target	VBG
cord-003091-uvfppirt	216	20	approaches	approach	NNS
cord-003091-uvfppirt	216	21	to	to	TO
cord-003091-uvfppirt	216	22	support	support	VB
cord-003091-uvfppirt	216	23	specific	specific	JJ
cord-003091-uvfppirt	216	24	DCs	DCs	NNP
cord-003091-uvfppirt	216	25	activation	activation	NN
cord-003091-uvfppirt	216	26	,	,	,
cord-003091-uvfppirt	216	27	avoid	avoid	VB
cord-003091-uvfppirt	216	28	tolerance	tolerance	NN
cord-003091-uvfppirt	216	29	,	,	,
cord-003091-uvfppirt	216	30	and	and	CC
cord-003091-uvfppirt	216	31	induce	induce	VB
cord-003091-uvfppirt	216	32	robust	robust	JJ
cord-003091-uvfppirt	216	33	T	t	NN
cord-003091-uvfppirt	216	34	cell	cell	NN
cord-003091-uvfppirt	216	35	immunity	immunity	NN
cord-003091-uvfppirt	216	36	(	(	-LRB-
cord-003091-uvfppirt	216	37	110	110	CD
cord-003091-uvfppirt	216	38	,	,	,
cord-003091-uvfppirt	216	39	141	141	CD
cord-003091-uvfppirt	216	40	)	)	-RRB-
cord-003091-uvfppirt	216	41	.	.	.
cord-003091-uvfppirt	217	1	When	when	WRB
cord-003091-uvfppirt	217	2	evaluating	evaluate	VBG
cord-003091-uvfppirt	217	3	vaccination	vaccination	NN
cord-003091-uvfppirt	217	4	strategies	strategy	NNS
cord-003091-uvfppirt	217	5	for	for	IN
cord-003091-uvfppirt	217	6	cancer	cancer	NN
cord-003091-uvfppirt	217	7	patients	patient	NNS
cord-003091-uvfppirt	217	8	,	,	,
cord-003091-uvfppirt	217	9	it	-PRON-	PRP
cord-003091-uvfppirt	217	10	is	be	VBZ
cord-003091-uvfppirt	217	11	compulsory	compulsory	JJ
cord-003091-uvfppirt	217	12	to	to	TO
cord-003091-uvfppirt	217	13	take	take	VB
cord-003091-uvfppirt	217	14	into	into	IN
cord-003091-uvfppirt	217	15	account	account	NN
cord-003091-uvfppirt	217	16	one	one	CD
cord-003091-uvfppirt	217	17	of	of	IN
cord-003091-uvfppirt	217	18	the	the	DT
cord-003091-uvfppirt	217	19	hallmarks	hallmark	NNS
cord-003091-uvfppirt	217	20	of	of	IN
cord-003091-uvfppirt	217	21	cancer	cancer	NN
cord-003091-uvfppirt	217	22	:	:	:
cord-003091-uvfppirt	217	23	avoiding	avoid	VBG
cord-003091-uvfppirt	217	24	immune	immune	JJ
cord-003091-uvfppirt	217	25	destruction	destruction	NN
cord-003091-uvfppirt	217	26	by	by	IN
cord-003091-uvfppirt	217	27	promoting	promote	VBG
cord-003091-uvfppirt	217	28	tolerance	tolerance	NN
cord-003091-uvfppirt	217	29	and	and	CC
cord-003091-uvfppirt	217	30	disarming	disarm	VBG
cord-003091-uvfppirt	217	31	the	the	DT
cord-003091-uvfppirt	217	32	immune	immune	JJ
cord-003091-uvfppirt	217	33	system	system	NN
cord-003091-uvfppirt	217	34	(	(	-LRB-
cord-003091-uvfppirt	217	35	5	5	CD
cord-003091-uvfppirt	217	36	)	)	-RRB-
cord-003091-uvfppirt	217	37	.	.	.
cord-003091-uvfppirt	218	1	The	the	DT
cord-003091-uvfppirt	218	2	orchestration	orchestration	NN
cord-003091-uvfppirt	218	3	of	of	IN
cord-003091-uvfppirt	218	4	antitumor	antitumor	JJ
cord-003091-uvfppirt	218	5	responses	response	NNS
cord-003091-uvfppirt	218	6	involves	involve	VBZ
cord-003091-uvfppirt	218	7	multiple	multiple	JJ
cord-003091-uvfppirt	218	8	protagonists	protagonist	NNS
cord-003091-uvfppirt	218	9	and	and	CC
cord-003091-uvfppirt	218	10	mediators	mediator	NNS
cord-003091-uvfppirt	218	11	,	,	,
cord-003091-uvfppirt	218	12	among	among	IN
cord-003091-uvfppirt	218	13	these	these	DT
cord-003091-uvfppirt	218	14	,	,	,
cord-003091-uvfppirt	218	15	cytotoxic	cytotoxic	JJ
cord-003091-uvfppirt	218	16	T	t	NN
cord-003091-uvfppirt	218	17	cells	cell	NNS
cord-003091-uvfppirt	218	18	and	and	CC
cord-003091-uvfppirt	218	19	NK	NK	NNP
cord-003091-uvfppirt	218	20	cells	cell	NNS
cord-003091-uvfppirt	218	21	,	,	,
cord-003091-uvfppirt	218	22	whose	whose	WP$
cord-003091-uvfppirt	218	23	activation	activation	NN
cord-003091-uvfppirt	218	24	is	be	VBZ
cord-003091-uvfppirt	218	25	supported	support	VBN
cord-003091-uvfppirt	218	26	by	by	IN
cord-003091-uvfppirt	218	27	DCs	DCs	NNP
cord-003091-uvfppirt	218	28	(	(	-LRB-
cord-003091-uvfppirt	218	29	151	151	CD
cord-003091-uvfppirt	218	30	)	)	-RRB-
cord-003091-uvfppirt	218	31	.	.	.
cord-003091-uvfppirt	219	1	Furthermore	furthermore	RB
cord-003091-uvfppirt	219	2	,	,	,
cord-003091-uvfppirt	219	3	DCs	DCs	NNP
cord-003091-uvfppirt	219	4	-	-	HYPH
cord-003091-uvfppirt	219	5	based	base	VBN
cord-003091-uvfppirt	219	6	vaccines	vaccine	NNS
cord-003091-uvfppirt	219	7	has	have	VBZ
cord-003091-uvfppirt	219	8	emerged	emerge	VBN
cord-003091-uvfppirt	219	9	as	as	IN
cord-003091-uvfppirt	219	10	more	more	RBR
cord-003091-uvfppirt	219	11	efficient	efficient	JJ
cord-003091-uvfppirt	219	12	in	in	IN
cord-003091-uvfppirt	219	13	promoting	promote	VBG
cord-003091-uvfppirt	219	14	T	t	NN
cord-003091-uvfppirt	219	15	cell	cell	NN
cord-003091-uvfppirt	219	16	immunity	immunity	NN
cord-003091-uvfppirt	219	17	if	if	IN
cord-003091-uvfppirt	219	18	compared	compare	VBN
cord-003091-uvfppirt	219	19	to	to	IN
cord-003091-uvfppirt	219	20	peptide	peptide	NN
cord-003091-uvfppirt	219	21	-	-	HYPH
cord-003091-uvfppirt	219	22	based	base	VBN
cord-003091-uvfppirt	219	23	vaccination	vaccination	NN
cord-003091-uvfppirt	219	24	approaches	approach	NNS
cord-003091-uvfppirt	219	25	(	(	-LRB-
cord-003091-uvfppirt	219	26	152	152	CD
cord-003091-uvfppirt	219	27	)	)	-RRB-
cord-003091-uvfppirt	219	28	.	.	.
cord-003091-uvfppirt	220	1	Thus	thus	RB
cord-003091-uvfppirt	220	2	,	,	,
cord-003091-uvfppirt	220	3	much	much	JJ
cord-003091-uvfppirt	220	4	effort	effort	NN
cord-003091-uvfppirt	220	5	has	have	VBZ
cord-003091-uvfppirt	220	6	been	be	VBN
cord-003091-uvfppirt	220	7	made	make	VBN
cord-003091-uvfppirt	220	8	to	to	TO
cord-003091-uvfppirt	220	9	improve	improve	VB
cord-003091-uvfppirt	220	10	strategies	strategy	NNS
cord-003091-uvfppirt	220	11	of	of	IN
cord-003091-uvfppirt	220	12	DCs	DCs	NNP
cord-003091-uvfppirt	220	13	-	-	HYPH
cord-003091-uvfppirt	220	14	based	base	VBN
cord-003091-uvfppirt	220	15	vaccination	vaccination	NN
cord-003091-uvfppirt	220	16	in	in	IN
cord-003091-uvfppirt	220	17	neoplastic	neoplastic	JJ
cord-003091-uvfppirt	220	18	diseases	disease	NNS
cord-003091-uvfppirt	220	19	,	,	,
cord-003091-uvfppirt	220	20	to	to	TO
cord-003091-uvfppirt	220	21	ameliorate	ameliorate	VB
cord-003091-uvfppirt	220	22	the	the	DT
cord-003091-uvfppirt	220	23	prognosis	prognosis	NN
cord-003091-uvfppirt	220	24	or	or	CC
cord-003091-uvfppirt	220	25	eradicate	eradicate	VB
cord-003091-uvfppirt	220	26	both	both	DT
cord-003091-uvfppirt	220	27	primary	primary	JJ
cord-003091-uvfppirt	220	28	tumor	tumor	NN
cord-003091-uvfppirt	220	29	and	and	CC
cord-003091-uvfppirt	220	30	metastases	metastasis	NNS
cord-003091-uvfppirt	220	31	.	.	.
cord-003091-uvfppirt	221	1	Up	up	IN
cord-003091-uvfppirt	221	2	to	to	IN
cord-003091-uvfppirt	221	3	now	now	RB
cord-003091-uvfppirt	221	4	,	,	,
cord-003091-uvfppirt	221	5	two	two	CD
cord-003091-uvfppirt	221	6	different	different	JJ
cord-003091-uvfppirt	221	7	approaches	approach	NNS
cord-003091-uvfppirt	221	8	have	have	VBP
cord-003091-uvfppirt	221	9	been	be	VBN
cord-003091-uvfppirt	221	10	addressed	address	VBN
cord-003091-uvfppirt	221	11	:	:	:
cord-003091-uvfppirt	221	12	ex	ex	FW
cord-003091-uvfppirt	221	13	vivo	vivo	NN
cord-003091-uvfppirt	221	14	generation	generation	NN
cord-003091-uvfppirt	221	15	of	of	IN
cord-003091-uvfppirt	221	16	autologous	autologous	JJ
cord-003091-uvfppirt	221	17	pulsed	pulse	VBN
cord-003091-uvfppirt	221	18	DCs	dc	NNS
cord-003091-uvfppirt	221	19	and	and	CC
cord-003091-uvfppirt	221	20	direct	direct	JJ
cord-003091-uvfppirt	221	21	in	in	IN
cord-003091-uvfppirt	221	22	vivo	vivo	NN
cord-003091-uvfppirt	221	23	targeting	target	VBG
cord-003091-uvfppirt	221	24	of	of	IN
cord-003091-uvfppirt	221	25	DCs	DCs	NNP
cord-003091-uvfppirt	221	26	,	,	,
cord-003091-uvfppirt	221	27	as	as	IN
cord-003091-uvfppirt	221	28	previously	previously	RB
cord-003091-uvfppirt	221	29	discussed	discuss	VBN
cord-003091-uvfppirt	221	30	.	.	.
cord-003091-uvfppirt	222	1	The	the	DT
cord-003091-uvfppirt	222	2	former	former	JJ
cord-003091-uvfppirt	222	3	strategy	strategy	NN
cord-003091-uvfppirt	222	4	provides	provide	VBZ
cord-003091-uvfppirt	222	5	a	a	DT
cord-003091-uvfppirt	222	6	better	well	JJR
cord-003091-uvfppirt	222	7	control	control	NN
cord-003091-uvfppirt	222	8	of	of	IN
cord-003091-uvfppirt	222	9	the	the	DT
cord-003091-uvfppirt	222	10	maturation	maturation	NN
cord-003091-uvfppirt	222	11	and	and	CC
cord-003091-uvfppirt	222	12	activation	activation	NN
cord-003091-uvfppirt	222	13	state	state	NN
cord-003091-uvfppirt	222	14	of	of	IN
cord-003091-uvfppirt	222	15	DCs	DCs	NNP
cord-003091-uvfppirt	222	16	and	and	CC
cord-003091-uvfppirt	222	17	a	a	DT
cord-003091-uvfppirt	222	18	specific	specific	JJ
cord-003091-uvfppirt	222	19	load	load	NN
cord-003091-uvfppirt	222	20	of	of	IN
cord-003091-uvfppirt	222	21	the	the	DT
cord-003091-uvfppirt	222	22	ag	ag	NNP
cord-003091-uvfppirt	222	23	to	to	IN
cord-003091-uvfppirt	222	24	the	the	DT
cord-003091-uvfppirt	222	25	selected	select	VBN
cord-003091-uvfppirt	222	26	DCs	DCs	NNP
cord-003091-uvfppirt	222	27	subset	subset	NNP
cord-003091-uvfppirt	222	28	.	.	.
cord-003091-uvfppirt	223	1	Despite	despite	IN
cord-003091-uvfppirt	223	2	this	this	DT
cord-003091-uvfppirt	223	3	,	,	,
cord-003091-uvfppirt	223	4	intense	intense	JJ
cord-003091-uvfppirt	223	5	work	work	NN
cord-003091-uvfppirt	223	6	is	be	VBZ
cord-003091-uvfppirt	223	7	needed	need	VBN
cord-003091-uvfppirt	223	8	to	to	TO
cord-003091-uvfppirt	223	9	generate	generate	VB
cord-003091-uvfppirt	223	10	this	this	DT
cord-003091-uvfppirt	223	11	vaccine	vaccine	NN
cord-003091-uvfppirt	223	12	,	,	,
cord-003091-uvfppirt	223	13	since	since	IN
cord-003091-uvfppirt	223	14	it	-PRON-	PRP
cord-003091-uvfppirt	223	15	is	be	VBZ
cord-003091-uvfppirt	223	16	personalized	personalize	VBN
cord-003091-uvfppirt	223	17	for	for	IN
cord-003091-uvfppirt	223	18	each	each	DT
cord-003091-uvfppirt	223	19	patient	patient	JJ
cord-003091-uvfppirt	223	20	and	and	CC
cord-003091-uvfppirt	223	21	only	only	RB
cord-003091-uvfppirt	223	22	few	few	JJ
cord-003091-uvfppirt	223	23	subsets	subset	NNS
cord-003091-uvfppirt	223	24	of	of	IN
cord-003091-uvfppirt	223	25	DCs	dc	NNS
cord-003091-uvfppirt	223	26	are	be	VBP
cord-003091-uvfppirt	223	27	feasibly	feasibly	RB
cord-003091-uvfppirt	223	28	generated	generate	VBN
cord-003091-uvfppirt	223	29	in	in	IN
cord-003091-uvfppirt	223	30	vitro	vitro	FW
cord-003091-uvfppirt	223	31	or	or	CC
cord-003091-uvfppirt	223	32	collected	collect	VBN
cord-003091-uvfppirt	223	33	ex	ex	FW
cord-003091-uvfppirt	223	34	vivo	vivo	NN
cord-003091-uvfppirt	223	35	,	,	,
cord-003091-uvfppirt	223	36	limiting	limit	VBG
cord-003091-uvfppirt	223	37	the	the	DT
cord-003091-uvfppirt	223	38	access	access	NN
cord-003091-uvfppirt	223	39	of	of	IN
cord-003091-uvfppirt	223	40	ags	ag	NNS
cord-003091-uvfppirt	223	41	to	to	IN
cord-003091-uvfppirt	223	42	other	other	JJ
cord-003091-uvfppirt	223	43	more	more	RBR
cord-003091-uvfppirt	223	44	functionally	functionally	RB
cord-003091-uvfppirt	223	45	driven	drive	VBN
cord-003091-uvfppirt	223	46	subsets	subset	NNS
cord-003091-uvfppirt	223	47	.	.	.
cord-003091-uvfppirt	224	1	Diversely	diversely	RB
cord-003091-uvfppirt	224	2	,	,	,
cord-003091-uvfppirt	224	3	the	the	DT
cord-003091-uvfppirt	224	4	in	in	IN
cord-003091-uvfppirt	224	5	vivo	vivo	NN
cord-003091-uvfppirt	224	6	targeting	target	VBG
cord-003091-uvfppirt	224	7	methods	method	NNS
cord-003091-uvfppirt	224	8	allow	allow	VBP
cord-003091-uvfppirt	224	9	the	the	DT
cord-003091-uvfppirt	224	10	generation	generation	NN
cord-003091-uvfppirt	224	11	of	of	IN
cord-003091-uvfppirt	224	12	large	large	JJ
cord-003091-uvfppirt	224	13	amount	amount	NN
cord-003091-uvfppirt	224	14	of	of	IN
cord-003091-uvfppirt	224	15	vaccine	vaccine	NN
cord-003091-uvfppirt	224	16	in	in	IN
cord-003091-uvfppirt	224	17	a	a	DT
cord-003091-uvfppirt	224	18	one	one	CD
cord-003091-uvfppirt	224	19	-	-	HYPH
cord-003091-uvfppirt	224	20	step	step	NN
cord-003091-uvfppirt	224	21	procedure	procedure	NN
cord-003091-uvfppirt	224	22	,	,	,
cord-003091-uvfppirt	224	23	and	and	CC
cord-003091-uvfppirt	224	24	the	the	DT
cord-003091-uvfppirt	224	25	targeting	targeting	NN
cord-003091-uvfppirt	224	26	of	of	IN
cord-003091-uvfppirt	224	27	diverse	diverse	JJ
cord-003091-uvfppirt	224	28	DCs	dc	NNS
cord-003091-uvfppirt	224	29	subsets	subset	NNS
cord-003091-uvfppirt	224	30	in	in	IN
cord-003091-uvfppirt	224	31	their	-PRON-	PRP$
cord-003091-uvfppirt	224	32	natural	natural	JJ
cord-003091-uvfppirt	224	33	environment	environment	NN
cord-003091-uvfppirt	224	34	.	.	.
cord-003091-uvfppirt	225	1	Once	once	IN
cord-003091-uvfppirt	225	2	the	the	DT
cord-003091-uvfppirt	225	3	DCs	DCs	NNP
cord-003091-uvfppirt	225	4	-	-	HYPH
cord-003091-uvfppirt	225	5	based	base	VBN
cord-003091-uvfppirt	225	6	vaccine	vaccine	NN
cord-003091-uvfppirt	225	7	is	be	VBZ
cord-003091-uvfppirt	225	8	generated	generate	VBN
cord-003091-uvfppirt	225	9	,	,	,
cord-003091-uvfppirt	225	10	the	the	DT
cord-003091-uvfppirt	225	11	efficacy	efficacy	NN
cord-003091-uvfppirt	225	12	of	of	IN
cord-003091-uvfppirt	225	13	antitumoral	antitumoral	JJ
cord-003091-uvfppirt	225	14	responses	response	NNS
cord-003091-uvfppirt	225	15	has	have	VBZ
cord-003091-uvfppirt	225	16	to	to	TO
cord-003091-uvfppirt	225	17	be	be	VB
cord-003091-uvfppirt	225	18	evaluated	evaluate	VBN
cord-003091-uvfppirt	225	19	.	.	.
cord-003091-uvfppirt	226	1	It	-PRON-	PRP
cord-003091-uvfppirt	226	2	is	be	VBZ
cord-003091-uvfppirt	226	3	mainly	mainly	RB
cord-003091-uvfppirt	226	4	related	relate	VBN
cord-003091-uvfppirt	226	5	to	to	IN
cord-003091-uvfppirt	226	6	(	(	-LRB-
cord-003091-uvfppirt	226	7	i	i	NN
cord-003091-uvfppirt	226	8	)	)	-RRB-
cord-003091-uvfppirt	227	1	the	the	DT
cord-003091-uvfppirt	227	2	capability	capability	NN
cord-003091-uvfppirt	227	3	to	to	TO
cord-003091-uvfppirt	227	4	establish	establish	VB
cord-003091-uvfppirt	227	5	specific	specific	JJ
cord-003091-uvfppirt	227	6	antitumor	antitumor	NN
cord-003091-uvfppirt	227	7	-	-	HYPH
cord-003091-uvfppirt	227	8	associated	associate	VBN
cord-003091-uvfppirt	227	9	ag	ag	NNP
cord-003091-uvfppirt	227	10	(	(	-LRB-
cord-003091-uvfppirt	227	11	TAA	TAA	NNP
cord-003091-uvfppirt	227	12	)	)	-RRB-
cord-003091-uvfppirt	227	13	immunity	immunity	NN
cord-003091-uvfppirt	227	14	and	and	CC
cord-003091-uvfppirt	227	15	(	(	-LRB-
cord-003091-uvfppirt	227	16	ii	ii	NN
cord-003091-uvfppirt	227	17	)	)	-RRB-
cord-003091-uvfppirt	228	1	the	the	DT
cord-003091-uvfppirt	228	2	overcome	overcome	NN
cord-003091-uvfppirt	228	3	of	of	IN
cord-003091-uvfppirt	228	4	the	the	DT
cord-003091-uvfppirt	228	5	tolerogenic	tolerogenic	NNP
cord-003091-uvfppirt	228	6	status	status	NN
cord-003091-uvfppirt	228	7	promoted	promote	VBN
cord-003091-uvfppirt	228	8	by	by	IN
cord-003091-uvfppirt	228	9	the	the	DT
cord-003091-uvfppirt	228	10	TME	TME	NNP
cord-003091-uvfppirt	228	11	.	.	.
cord-003091-uvfppirt	229	1	To	to	TO
cord-003091-uvfppirt	229	2	select	select	VB
cord-003091-uvfppirt	229	3	highly	highly	RB
cord-003091-uvfppirt	229	4	immunogenic	immunogenic	JJ
cord-003091-uvfppirt	229	5	ags	ag	NNS
cord-003091-uvfppirt	229	6	,	,	,
cord-003091-uvfppirt	229	7	multiple	multiple	JJ
cord-003091-uvfppirt	229	8	solutions	solution	NNS
cord-003091-uvfppirt	229	9	have	have	VBP
cord-003091-uvfppirt	229	10	been	be	VBN
cord-003091-uvfppirt	229	11	tested	test	VBN
cord-003091-uvfppirt	229	12	:	:	:
cord-003091-uvfppirt	229	13	whole	whole	JJ
cord-003091-uvfppirt	229	14	tumor	tumor	NN
cord-003091-uvfppirt	229	15	lysate	lysate	NN
cord-003091-uvfppirt	229	16	or	or	CC
cord-003091-uvfppirt	229	17	killed	kill	VBD
cord-003091-uvfppirt	229	18	tumor	tumor	NN
cord-003091-uvfppirt	229	19	cells	cell	NNS
cord-003091-uvfppirt	229	20	,	,	,
cord-003091-uvfppirt	229	21	synthetic	synthetic	JJ
cord-003091-uvfppirt	229	22	long	long	JJ
cord-003091-uvfppirt	229	23	peptides	peptide	NNS
cord-003091-uvfppirt	229	24	(	(	-LRB-
cord-003091-uvfppirt	229	25	SLPs	SLPs	NNP
cord-003091-uvfppirt	229	26	)	)	-RRB-
cord-003091-uvfppirt	229	27	,	,	,
cord-003091-uvfppirt	229	28	full	full	JJ
cord-003091-uvfppirt	229	29	length	length	NN
cord-003091-uvfppirt	229	30	proteins	protein	NNS
cord-003091-uvfppirt	229	31	,	,	,
cord-003091-uvfppirt	229	32	transfection	transfection	NN
cord-003091-uvfppirt	229	33	or	or	CC
cord-003091-uvfppirt	229	34	electroporation	electroporation	NN
cord-003091-uvfppirt	229	35	with	with	IN
cord-003091-uvfppirt	229	36	DNA	DNA	NNP
cord-003091-uvfppirt	229	37	or	or	CC
cord-003091-uvfppirt	229	38	mRNA	mrna	NN
cord-003091-uvfppirt	229	39	coding	code	VBG
cord-003091-uvfppirt	229	40	for	for	IN
cord-003091-uvfppirt	229	41	TAA	TAA	NNP
cord-003091-uvfppirt	229	42	,	,	,
cord-003091-uvfppirt	229	43	transduction	transduction	NN
cord-003091-uvfppirt	229	44	with	with	IN
cord-003091-uvfppirt	229	45	lentiviral	lentiviral	JJ
cord-003091-uvfppirt	229	46	vectors	vector	NNS
cord-003091-uvfppirt	229	47	and	and	CC
cord-003091-uvfppirt	229	48	neoantigens	neoantigen	NNS
cord-003091-uvfppirt	229	49	.	.	.
cord-003091-uvfppirt	230	1	The	the	DT
cord-003091-uvfppirt	230	2	availability	availability	NN
cord-003091-uvfppirt	230	3	of	of	IN
cord-003091-uvfppirt	230	4	an	an	DT
cord-003091-uvfppirt	230	5	elevated	elevated	JJ
cord-003091-uvfppirt	230	6	number	number	NN
cord-003091-uvfppirt	230	7	of	of	IN
cord-003091-uvfppirt	230	8	antigens	antigen	NNS
cord-003091-uvfppirt	230	9	through	through	IN
cord-003091-uvfppirt	230	10	the	the	DT
cord-003091-uvfppirt	230	11	incubation	incubation	NN
cord-003091-uvfppirt	230	12	of	of	IN
cord-003091-uvfppirt	230	13	DCs	DCs	NNP
cord-003091-uvfppirt	230	14	with	with	IN
cord-003091-uvfppirt	230	15	whole	whole	JJ
cord-003091-uvfppirt	230	16	tumor	tumor	NN
cord-003091-uvfppirt	230	17	lysates	lysate	NNS
cord-003091-uvfppirt	230	18	or	or	CC
cord-003091-uvfppirt	230	19	autologous	autologous	JJ
cord-003091-uvfppirt	230	20	tumor	tumor	NN
cord-003091-uvfppirt	230	21	cells	cell	NNS
cord-003091-uvfppirt	230	22	allows	allow	VBZ
cord-003091-uvfppirt	230	23	the	the	DT
cord-003091-uvfppirt	230	24	presentation	presentation	NN
cord-003091-uvfppirt	230	25	of	of	IN
cord-003091-uvfppirt	230	26	multiple	multiple	JJ
cord-003091-uvfppirt	230	27	epitopes	epitope	NNS
cord-003091-uvfppirt	230	28	,	,	,
cord-003091-uvfppirt	230	29	loaded	load	VBN
cord-003091-uvfppirt	230	30	on	on	IN
cord-003091-uvfppirt	230	31	both	both	DT
cord-003091-uvfppirt	230	32	MHC	MHC	NNP
cord-003091-uvfppirt	230	33	class	class	NN
cord-003091-uvfppirt	230	34	I	i	NN
cord-003091-uvfppirt	230	35	or	or	CC
cord-003091-uvfppirt	230	36	II	II	NNP
cord-003091-uvfppirt	230	37	,	,	,
cord-003091-uvfppirt	230	38	which	which	WDT
cord-003091-uvfppirt	230	39	leads	lead	VBZ
cord-003091-uvfppirt	230	40	to	to	IN
cord-003091-uvfppirt	230	41	Th	th	JJ
cord-003091-uvfppirt	230	42	and	and	CC
cord-003091-uvfppirt	230	43	cytotoxic	cytotoxic	JJ
cord-003091-uvfppirt	230	44	responses	response	NNS
cord-003091-uvfppirt	230	45	.	.	.
cord-003091-uvfppirt	231	1	Indeed	indeed	RB
cord-003091-uvfppirt	231	2	,	,	,
cord-003091-uvfppirt	231	3	several	several	JJ
cord-003091-uvfppirt	231	4	clinical	clinical	JJ
cord-003091-uvfppirt	231	5	trials	trial	NNS
cord-003091-uvfppirt	231	6	are	be	VBP
cord-003091-uvfppirt	231	7	currently	currently	RB
cord-003091-uvfppirt	231	8	evaluating	evaluate	VBG
cord-003091-uvfppirt	231	9	the	the	DT
cord-003091-uvfppirt	231	10	benefits	benefit	NNS
cord-003091-uvfppirt	231	11	obtained	obtain	VBN
cord-003091-uvfppirt	231	12	by	by	IN
cord-003091-uvfppirt	231	13	using	use	VBG
cord-003091-uvfppirt	231	14	this	this	DT
cord-003091-uvfppirt	231	15	approach	approach	NN
cord-003091-uvfppirt	231	16	(	(	-LRB-
cord-003091-uvfppirt	231	17	NCT01875653	nct01875653	RB
cord-003091-uvfppirt	231	18	;	;	:
cord-003091-uvfppirt	231	19	NCT00045968	NCT00045968	NNP
cord-003091-uvfppirt	231	20	;	;	:
cord-003091-uvfppirt	231	21	NCT02496520	NCT02496520	NNPS
cord-003091-uvfppirt	231	22	)	)	-RRB-
cord-003091-uvfppirt	231	23	.	.	.
cord-003091-uvfppirt	232	1	SLPs	slp	NNS
cord-003091-uvfppirt	232	2	are	be	VBP
cord-003091-uvfppirt	232	3	28	28	CD
cord-003091-uvfppirt	232	4	-	-	SYM
cord-003091-uvfppirt	232	5	35	35	CD
cord-003091-uvfppirt	232	6	aa	aa	NNP
cord-003091-uvfppirt	232	7	long	long	JJ
cord-003091-uvfppirt	232	8	peptides	peptide	NNS
cord-003091-uvfppirt	232	9	cross	cross	VBP
cord-003091-uvfppirt	232	10	-	-	VBN
cord-003091-uvfppirt	232	11	presented	present	VBN
cord-003091-uvfppirt	232	12	by	by	IN
cord-003091-uvfppirt	232	13	DCs	DCs	NNP
cord-003091-uvfppirt	232	14	(	(	-LRB-
cord-003091-uvfppirt	232	15	153	153	CD
cord-003091-uvfppirt	232	16	)	)	-RRB-
cord-003091-uvfppirt	232	17	,	,	,
cord-003091-uvfppirt	232	18	currently	currently	RB
cord-003091-uvfppirt	232	19	under	under	IN
cord-003091-uvfppirt	232	20	investigation	investigation	NN
cord-003091-uvfppirt	232	21	in	in	IN
cord-003091-uvfppirt	232	22	both	both	DT
cord-003091-uvfppirt	232	23	preclinical	preclinical	JJ
cord-003091-uvfppirt	232	24	and	and	CC
cord-003091-uvfppirt	232	25	clinical	clinical	JJ
cord-003091-uvfppirt	232	26	setting	setting	NN
cord-003091-uvfppirt	232	27	.	.	.
cord-003091-uvfppirt	233	1	Compared	compare	VBN
cord-003091-uvfppirt	233	2	to	to	IN
cord-003091-uvfppirt	233	3	short	short	JJ
cord-003091-uvfppirt	233	4	synthetic	synthetic	JJ
cord-003091-uvfppirt	233	5	peptides	peptide	NNS
cord-003091-uvfppirt	233	6	,	,	,
cord-003091-uvfppirt	233	7	the	the	DT
cord-003091-uvfppirt	233	8	use	use	NN
cord-003091-uvfppirt	233	9	of	of	IN
cord-003091-uvfppirt	233	10	SLPs	SLPs	NNP
cord-003091-uvfppirt	233	11	lacks	lack	VBZ
cord-003091-uvfppirt	233	12	the	the	DT
cord-003091-uvfppirt	233	13	necessity	necessity	NN
cord-003091-uvfppirt	233	14	to	to	TO
cord-003091-uvfppirt	233	15	know	know	VB
cord-003091-uvfppirt	233	16	the	the	DT
cord-003091-uvfppirt	233	17	patients	patient	NNS
cord-003091-uvfppirt	233	18	'	'	POS
cord-003091-uvfppirt	233	19	HLA	HLA	NNP
cord-003091-uvfppirt	233	20	haplotype	haplotype	NN
cord-003091-uvfppirt	233	21	,	,	,
cord-003091-uvfppirt	233	22	thus	thus	RB
cord-003091-uvfppirt	233	23	permitting	permit	VBG
cord-003091-uvfppirt	233	24	their	-PRON-	PRP$
cord-003091-uvfppirt	233	25	full	full	JJ
cord-003091-uvfppirt	233	26	exploitation	exploitation	NN
cord-003091-uvfppirt	233	27	in	in	IN
cord-003091-uvfppirt	233	28	a	a	DT
cord-003091-uvfppirt	233	29	larger	large	JJR
cord-003091-uvfppirt	233	30	cohort	cohort	NN
cord-003091-uvfppirt	233	31	of	of	IN
cord-003091-uvfppirt	233	32	people	people	NNS
cord-003091-uvfppirt	233	33	.	.	.
cord-003091-uvfppirt	234	1	Moreover	moreover	RB
cord-003091-uvfppirt	234	2	,	,	,
cord-003091-uvfppirt	234	3	SLPs	SLPs	NNP
cord-003091-uvfppirt	234	4	administration	administration	NN
cord-003091-uvfppirt	234	5	to	to	IN
cord-003091-uvfppirt	234	6	DCs	DCs	NNP
cord-003091-uvfppirt	234	7	leads	lead	VBZ
cord-003091-uvfppirt	234	8	to	to	IN
cord-003091-uvfppirt	234	9	an	an	DT
cord-003091-uvfppirt	234	10	enhanced	enhanced	JJ
cord-003091-uvfppirt	234	11	CD8	CD8	NNP
cord-003091-uvfppirt	234	12	+	+	CC
cord-003091-uvfppirt	234	13	T	T	NNP
cord-003091-uvfppirt	234	14	cells	cell	NNS
cord-003091-uvfppirt	234	15	activation	activation	NN
cord-003091-uvfppirt	234	16	since	since	IN
cord-003091-uvfppirt	234	17	,	,	,
cord-003091-uvfppirt	234	18	once	once	RB
cord-003091-uvfppirt	234	19	engulfed	engulf	VBN
cord-003091-uvfppirt	234	20	,	,	,
cord-003091-uvfppirt	234	21	they	-PRON-	PRP
cord-003091-uvfppirt	234	22	rapidly	rapidly	RB
cord-003091-uvfppirt	234	23	escape	escape	VBP
cord-003091-uvfppirt	234	24	from	from	IN
cord-003091-uvfppirt	234	25	the	the	DT
cord-003091-uvfppirt	234	26	endolysosome	endolysosome	NN
cord-003091-uvfppirt	234	27	to	to	TO
cord-003091-uvfppirt	234	28	follow	follow	VB
cord-003091-uvfppirt	234	29	the	the	DT
cord-003091-uvfppirt	234	30	path	path	NN
cord-003091-uvfppirt	234	31	of	of	IN
cord-003091-uvfppirt	234	32	MHC	MHC	NNP
cord-003091-uvfppirt	234	33	class	class	NN
cord-003091-uvfppirt	234	34	I	-PRON-	PRP
cord-003091-uvfppirt	234	35	presentation	presentation	NN
cord-003091-uvfppirt	234	36	,	,	,
cord-003091-uvfppirt	234	37	fundamental	fundamental	JJ
cord-003091-uvfppirt	234	38	in	in	IN
cord-003091-uvfppirt	234	39	antitumor	antitumor	JJ
cord-003091-uvfppirt	234	40	responses	response	NNS
cord-003091-uvfppirt	234	41	.	.	.
cord-003091-uvfppirt	235	1	Indeed	indeed	RB
cord-003091-uvfppirt	235	2	,	,	,
cord-003091-uvfppirt	235	3	SLPs	slp	NNS
cord-003091-uvfppirt	235	4	and	and	CC
cord-003091-uvfppirt	235	5	DCs	DCs	NNP
cord-003091-uvfppirt	235	6	-	-	HYPH
cord-003091-uvfppirt	235	7	based	base	VBN
cord-003091-uvfppirt	235	8	vaccines	vaccine	NNS
cord-003091-uvfppirt	235	9	are	be	VBP
cord-003091-uvfppirt	235	10	showing	show	VBG
cord-003091-uvfppirt	235	11	promising	promising	JJ
cord-003091-uvfppirt	235	12	results	result	NNS
cord-003091-uvfppirt	235	13	in	in	IN
cord-003091-uvfppirt	235	14	terms	term	NNS
cord-003091-uvfppirt	235	15	of	of	IN
cord-003091-uvfppirt	235	16	safety	safety	NN
cord-003091-uvfppirt	235	17	and	and	CC
cord-003091-uvfppirt	235	18	immunogenicity	immunogenicity	NN
cord-003091-uvfppirt	235	19	,	,	,
cord-003091-uvfppirt	235	20	in	in	IN
cord-003091-uvfppirt	235	21	both	both	DT
cord-003091-uvfppirt	235	22	preclinical	preclinical	JJ
cord-003091-uvfppirt	235	23	and	and	CC
cord-003091-uvfppirt	235	24	clinical	clinical	JJ
cord-003091-uvfppirt	235	25	settings	setting	NNS
cord-003091-uvfppirt	235	26	(	(	-LRB-
cord-003091-uvfppirt	235	27	154	154	CD
cord-003091-uvfppirt	235	28	)	)	-RRB-
cord-003091-uvfppirt	235	29	.	.	.
cord-003091-uvfppirt	236	1	They	-PRON-	PRP
cord-003091-uvfppirt	236	2	have	have	VBP
cord-003091-uvfppirt	236	3	gained	gain	VBN
cord-003091-uvfppirt	236	4	attention	attention	NN
cord-003091-uvfppirt	236	5	in	in	IN
cord-003091-uvfppirt	236	6	the	the	DT
cord-003091-uvfppirt	236	7	context	context	NN
cord-003091-uvfppirt	236	8	of	of	IN
cord-003091-uvfppirt	236	9	human	human	JJ
cord-003091-uvfppirt	236	10	papilloma	papilloma	NN
cord-003091-uvfppirt	236	11	virus	virus	NN
cord-003091-uvfppirt	236	12	cervical	cervical	NN
cord-003091-uvfppirt	236	13	(	(	-LRB-
cord-003091-uvfppirt	236	14	155	155	CD
cord-003091-uvfppirt	236	15	)	)	-RRB-
cord-003091-uvfppirt	236	16	,	,	,
cord-003091-uvfppirt	236	17	ovarian	ovarian	NN
cord-003091-uvfppirt	236	18	(	(	-LRB-
cord-003091-uvfppirt	236	19	156	156	CD
cord-003091-uvfppirt	236	20	)	)	-RRB-
cord-003091-uvfppirt	236	21	,	,	,
cord-003091-uvfppirt	236	22	and	and	CC
cord-003091-uvfppirt	236	23	colorectal	colorectal	JJ
cord-003091-uvfppirt	236	24	cancer	cancer	NN
cord-003091-uvfppirt	236	25	(	(	-LRB-
cord-003091-uvfppirt	236	26	157	157	CD
cord-003091-uvfppirt	236	27	,	,	,
cord-003091-uvfppirt	236	28	158	158	CD
cord-003091-uvfppirt	236	29	)	)	-RRB-
cord-003091-uvfppirt	236	30	,	,	,
cord-003091-uvfppirt	236	31	displaying	display	VBG
cord-003091-uvfppirt	236	32	immunogenic	immunogenic	JJ
cord-003091-uvfppirt	236	33	capacities	capacity	NNS
cord-003091-uvfppirt	236	34	,	,	,
cord-003091-uvfppirt	236	35	in	in	IN
cord-003091-uvfppirt	236	36	terms	term	NNS
cord-003091-uvfppirt	236	37	of	of	IN
cord-003091-uvfppirt	236	38	antibody	antibody	NN
cord-003091-uvfppirt	236	39	production	production	NN
cord-003091-uvfppirt	236	40	and	and	CC
cord-003091-uvfppirt	236	41	CD4	CD4	NNP
cord-003091-uvfppirt	236	42	+	+	CC
cord-003091-uvfppirt	236	43	and	and	CC
cord-003091-uvfppirt	236	44	CD8	CD8	NNP
cord-003091-uvfppirt	236	45	+	+	CC
cord-003091-uvfppirt	236	46	T	T	NNP
cord-003091-uvfppirt	236	47	cell	cell	NN
cord-003091-uvfppirt	236	48	activation	activation	NN
cord-003091-uvfppirt	236	49	,	,	,
cord-003091-uvfppirt	236	50	when	when	WRB
cord-003091-uvfppirt	236	51	delivered	deliver	VBN
cord-003091-uvfppirt	236	52	with	with	IN
cord-003091-uvfppirt	236	53	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	236	54	,	,	,
cord-003091-uvfppirt	236	55	as	as	IN
cord-003091-uvfppirt	236	56	poly	poly	NNP
cord-003091-uvfppirt	236	57	ICLC	ICLC	NNP
cord-003091-uvfppirt	236	58	,	,	,
cord-003091-uvfppirt	236	59	Montanide	Montanide	NNP
cord-003091-uvfppirt	236	60	-	-	HYPH
cord-003091-uvfppirt	236	61	ISA-51	ISA-51	NNP
cord-003091-uvfppirt	236	62	(	(	-LRB-
cord-003091-uvfppirt	236	63	NCT02334735	NCT02334735	NNP
cord-003091-uvfppirt	236	64	)	)	-RRB-
cord-003091-uvfppirt	236	65	,	,	,
cord-003091-uvfppirt	236	66	and	and	CC
cord-003091-uvfppirt	236	67	IFNα	IFNα	NNS
cord-003091-uvfppirt	236	68	.	.	.
cord-003091-uvfppirt	237	1	When	when	WRB
cord-003091-uvfppirt	237	2	comparing	compare	VBG
cord-003091-uvfppirt	237	3	SLPs	slp	NNS
cord-003091-uvfppirt	237	4	and	and	CC
cord-003091-uvfppirt	237	5	full	full	JJ
cord-003091-uvfppirt	237	6	length	length	NN
cord-003091-uvfppirt	237	7	proteins	protein	NNS
cord-003091-uvfppirt	237	8	,	,	,
cord-003091-uvfppirt	237	9	it	-PRON-	PRP
cord-003091-uvfppirt	237	10	has	have	VBZ
cord-003091-uvfppirt	237	11	emerged	emerge	VBN
cord-003091-uvfppirt	237	12	that	that	IN
cord-003091-uvfppirt	237	13	DCs	DCs	NNP
cord-003091-uvfppirt	237	14	process	process	NN
cord-003091-uvfppirt	237	15	SLPs	SLPs	NNP
cord-003091-uvfppirt	237	16	better	well	RBR
cord-003091-uvfppirt	237	17	that	that	DT
cord-003091-uvfppirt	237	18	full	full	JJ
cord-003091-uvfppirt	237	19	length	length	NN
cord-003091-uvfppirt	237	20	protein	protein	NN
cord-003091-uvfppirt	237	21	,	,	,
cord-003091-uvfppirt	237	22	due	due	IN
cord-003091-uvfppirt	237	23	to	to	IN
cord-003091-uvfppirt	237	24	the	the	DT
cord-003091-uvfppirt	237	25	slower	slow	JJR
cord-003091-uvfppirt	237	26	processing	processing	NN
cord-003091-uvfppirt	237	27	route	route	NN
cord-003091-uvfppirt	237	28	the	the	DT
cord-003091-uvfppirt	237	29	latter	latter	JJ
cord-003091-uvfppirt	237	30	display	display	NN
cord-003091-uvfppirt	237	31	(	(	-LRB-
cord-003091-uvfppirt	237	32	154	154	CD
cord-003091-uvfppirt	237	33	)	)	-RRB-
cord-003091-uvfppirt	237	34	.	.	.
cord-003091-uvfppirt	238	1	Concerning	concern	VBG
cord-003091-uvfppirt	238	2	transfection	transfection	NN
cord-003091-uvfppirt	238	3	or	or	CC
cord-003091-uvfppirt	238	4	electroporation	electroporation	NN
cord-003091-uvfppirt	238	5	of	of	IN
cord-003091-uvfppirt	238	6	DCs	dc	NNS
cord-003091-uvfppirt	238	7	with	with	IN
cord-003091-uvfppirt	238	8	mRNA	mRNA	NNP
cord-003091-uvfppirt	238	9	or	or	CC
cord-003091-uvfppirt	238	10	DNA	dna	NN
cord-003091-uvfppirt	238	11	encoding	encoding	NN
cord-003091-uvfppirt	238	12	,	,	,
cord-003091-uvfppirt	238	13	not	not	RB
cord-003091-uvfppirt	238	14	only	only	RB
cord-003091-uvfppirt	238	15	for	for	IN
cord-003091-uvfppirt	238	16	TAA	TAA	NNP
cord-003091-uvfppirt	238	17	but	but	CC
cord-003091-uvfppirt	238	18	also	also	RB
cord-003091-uvfppirt	238	19	for	for	IN
cord-003091-uvfppirt	238	20	costimulatory	costimulatory	NN
cord-003091-uvfppirt	238	21	molecules	molecule	NNS
cord-003091-uvfppirt	238	22	and	and	CC
cord-003091-uvfppirt	238	23	cytokines	cytokine	NNS
cord-003091-uvfppirt	238	24	,	,	,
cord-003091-uvfppirt	238	25	to	to	TO
cord-003091-uvfppirt	238	26	enforce	enforce	VB
cord-003091-uvfppirt	238	27	adaptive	adaptive	JJ
cord-003091-uvfppirt	238	28	immunity	immunity	NN
cord-003091-uvfppirt	238	29	,	,	,
cord-003091-uvfppirt	238	30	has	have	VBZ
cord-003091-uvfppirt	238	31	proven	prove	VBN
cord-003091-uvfppirt	238	32	to	to	TO
cord-003091-uvfppirt	238	33	be	be	VB
cord-003091-uvfppirt	238	34	efficacious	efficacious	JJ
cord-003091-uvfppirt	238	35	in	in	IN
cord-003091-uvfppirt	238	36	inducing	induce	VBG
cord-003091-uvfppirt	238	37	antitumor	antitumor	JJ
cord-003091-uvfppirt	238	38	CD4	CD4	NNP
cord-003091-uvfppirt	238	39	+	+	CC
cord-003091-uvfppirt	238	40	and	and	CC
cord-003091-uvfppirt	238	41	CD8	CD8	NNP
cord-003091-uvfppirt	238	42	+	+	CC
cord-003091-uvfppirt	238	43	T	T	NNP
cord-003091-uvfppirt	238	44	cells	cell	NNS
cord-003091-uvfppirt	238	45	expansion	expansion	NN
cord-003091-uvfppirt	238	46	,	,	,
cord-003091-uvfppirt	238	47	mediated	mediate	VBN
cord-003091-uvfppirt	238	48	by	by	IN
cord-003091-uvfppirt	238	49	DCs	DCs	NNP
cord-003091-uvfppirt	238	50	targeting	target	VBG
cord-003091-uvfppirt	238	51	(	(	-LRB-
cord-003091-uvfppirt	238	52	159	159	CD
cord-003091-uvfppirt	238	53	)	)	-RRB-
cord-003091-uvfppirt	238	54	.	.	.
cord-003091-uvfppirt	239	1	A	a	DT
cord-003091-uvfppirt	239	2	similar	similar	JJ
cord-003091-uvfppirt	239	3	approach	approach	NN
cord-003091-uvfppirt	239	4	regards	regard	VBZ
cord-003091-uvfppirt	239	5	in	in	IN
cord-003091-uvfppirt	239	6	vivo	vivo	FW
cord-003091-uvfppirt	239	7	lentiviral	lentiviral	FW
cord-003091-uvfppirt	239	8	transduction	transduction	NN
cord-003091-uvfppirt	239	9	of	of	IN
cord-003091-uvfppirt	239	10	DCs	DCs	NNP
cord-003091-uvfppirt	239	11	,	,	,
cord-003091-uvfppirt	239	12	which	which	WDT
cord-003091-uvfppirt	239	13	displays	display	VBZ
cord-003091-uvfppirt	239	14	versatility	versatility	NN
cord-003091-uvfppirt	239	15	for	for	IN
cord-003091-uvfppirt	239	16	gene	gene	NN
cord-003091-uvfppirt	239	17	delivery	delivery	NN
cord-003091-uvfppirt	239	18	and	and	CC
cord-003091-uvfppirt	239	19	efficient	efficient	JJ
cord-003091-uvfppirt	239	20	transduction	transduction	NN
cord-003091-uvfppirt	239	21	for	for	IN
cord-003091-uvfppirt	239	22	non	non	JJ
cord-003091-uvfppirt	239	23	-	-	JJ
cord-003091-uvfppirt	239	24	dividing	dividing	JJ
cord-003091-uvfppirt	239	25	cells	cell	NNS
cord-003091-uvfppirt	239	26	,	,	,
cord-003091-uvfppirt	239	27	as	as	IN
cord-003091-uvfppirt	239	28	DCs	DCs	NNP
cord-003091-uvfppirt	239	29	.	.	.
cord-003091-uvfppirt	240	1	Indeed	indeed	RB
cord-003091-uvfppirt	240	2	,	,	,
cord-003091-uvfppirt	240	3	Bryson	Bryson	NNP
cord-003091-uvfppirt	240	4	et	et	NNP
cord-003091-uvfppirt	240	5	al	al	NNP
cord-003091-uvfppirt	240	6	.	.	NNP
cord-003091-uvfppirt	240	7	conceived	conceive	VBD
cord-003091-uvfppirt	240	8	a	a	DT
cord-003091-uvfppirt	240	9	multifunctional	multifunctional	JJ
cord-003091-uvfppirt	240	10	vaccine	vaccine	NN
cord-003091-uvfppirt	240	11	composed	compose	VBN
cord-003091-uvfppirt	240	12	by	by	IN
cord-003091-uvfppirt	240	13	a	a	DT
cord-003091-uvfppirt	240	14	modified	modify	VBN
cord-003091-uvfppirt	240	15	lentivirus	lentivirus	NN
cord-003091-uvfppirt	240	16	,	,	,
cord-003091-uvfppirt	240	17	whose	whose	WP$
cord-003091-uvfppirt	240	18	glycoproteins	glycoprotein	NNS
cord-003091-uvfppirt	240	19	can	can	MD
cord-003091-uvfppirt	240	20	directly	directly	RB
cord-003091-uvfppirt	240	21	target	target	VB
cord-003091-uvfppirt	240	22	DC	DC	NNP
cord-003091-uvfppirt	240	23	-	-	HYPH
cord-003091-uvfppirt	240	24	SIGN	SIGN	NNP
cord-003091-uvfppirt	240	25	on	on	IN
cord-003091-uvfppirt	240	26	DCs	DCs	NNP
cord-003091-uvfppirt	240	27	,	,	,
cord-003091-uvfppirt	240	28	loaded	load	VBN
cord-003091-uvfppirt	240	29	with	with	IN
cord-003091-uvfppirt	240	30	breast	breast	NN
cord-003091-uvfppirt	240	31	cancer	cancer	NN
cord-003091-uvfppirt	240	32	ags	ags	NNP
cord-003091-uvfppirt	240	33	,	,	,
cord-003091-uvfppirt	240	34	alpha	alpha	NN
cord-003091-uvfppirt	240	35	lactalbumin	lactalbumin	NNP
cord-003091-uvfppirt	240	36	,	,	,
cord-003091-uvfppirt	240	37	and	and	CC
cord-003091-uvfppirt	240	38	erb	erb	NN
cord-003091-uvfppirt	240	39	-	-	HYPH
cord-003091-uvfppirt	240	40	b2	b2	NN
cord-003091-uvfppirt	240	41	receptor	receptor	NN
cord-003091-uvfppirt	240	42	tyrosine	tyrosine	NN
cord-003091-uvfppirt	240	43	kinase	kinase	NN
cord-003091-uvfppirt	240	44	2	2	CD
cord-003091-uvfppirt	240	45	.	.	.
cord-003091-uvfppirt	241	1	Single	single	JJ
cord-003091-uvfppirt	241	2	injections	injection	NNS
cord-003091-uvfppirt	241	3	of	of	IN
cord-003091-uvfppirt	241	4	the	the	DT
cord-003091-uvfppirt	241	5	compound	compound	NN
cord-003091-uvfppirt	241	6	provided	provide	VBN
cord-003091-uvfppirt	241	7	tumor	tumor	NN
cord-003091-uvfppirt	241	8	self	self	NN
cord-003091-uvfppirt	241	9	-	-	HYPH
cord-003091-uvfppirt	241	10	ags	ags	NN
cord-003091-uvfppirt	241	11	-	-	HYPH
cord-003091-uvfppirt	241	12	specific	specific	JJ
cord-003091-uvfppirt	241	13	CD8	CD8	NNP
cord-003091-uvfppirt	241	14	+	+	CC
cord-003091-uvfppirt	241	15	T	t	NN
cord-003091-uvfppirt	241	16	cell	cell	NN
cord-003091-uvfppirt	241	17	immunity	immunity	NN
cord-003091-uvfppirt	241	18	,	,	,
cord-003091-uvfppirt	241	19	reducing	reduce	VBG
cord-003091-uvfppirt	241	20	tumor	tumor	NN
cord-003091-uvfppirt	241	21	growth	growth	NN
cord-003091-uvfppirt	241	22	(	(	-LRB-
cord-003091-uvfppirt	241	23	160	160	CD
cord-003091-uvfppirt	241	24	)	)	-RRB-
cord-003091-uvfppirt	241	25	.	.	.
cord-003091-uvfppirt	242	1	Despite	despite	IN
cord-003091-uvfppirt	242	2	the	the	DT
cord-003091-uvfppirt	242	3	improvements	improvement	NNS
cord-003091-uvfppirt	242	4	derived	derive	VBN
cord-003091-uvfppirt	242	5	by	by	IN
cord-003091-uvfppirt	242	6	these	these	DT
cord-003091-uvfppirt	242	7	advanced	advanced	JJ
cord-003091-uvfppirt	242	8	strategies	strategy	NNS
cord-003091-uvfppirt	242	9	,	,	,
cord-003091-uvfppirt	242	10	in	in	IN
cord-003091-uvfppirt	242	11	the	the	DT
cord-003091-uvfppirt	242	12	last	last	JJ
cord-003091-uvfppirt	242	13	years	year	NNS
cord-003091-uvfppirt	242	14	,	,	,
cord-003091-uvfppirt	242	15	neoantigens	neoantigen	NNS
cord-003091-uvfppirt	242	16	are	be	VBP
cord-003091-uvfppirt	242	17	becoming	become	VBG
cord-003091-uvfppirt	242	18	more	more	RBR
cord-003091-uvfppirt	242	19	and	and	CC
cord-003091-uvfppirt	242	20	more	more	RBR
cord-003091-uvfppirt	242	21	appealing	appealing	JJ
cord-003091-uvfppirt	242	22	(	(	-LRB-
cord-003091-uvfppirt	242	23	161	161	CD
cord-003091-uvfppirt	242	24	)	)	-RRB-
cord-003091-uvfppirt	242	25	.	.	.
cord-003091-uvfppirt	243	1	During	during	IN
cord-003091-uvfppirt	243	2	tumor	tumor	NN
cord-003091-uvfppirt	243	3	progression	progression	NN
cord-003091-uvfppirt	243	4	,	,	,
cord-003091-uvfppirt	243	5	cancer	cancer	NN
cord-003091-uvfppirt	243	6	cells	cell	NNS
cord-003091-uvfppirt	243	7	give	give	VBP
cord-003091-uvfppirt	243	8	rise	rise	NN
cord-003091-uvfppirt	243	9	to	to	IN
cord-003091-uvfppirt	243	10	neoantigens	neoantigens	NNP
cord-003091-uvfppirt	243	11	,	,	,
cord-003091-uvfppirt	243	12	novel	novel	JJ
cord-003091-uvfppirt	243	13	ags	ag	NNS
cord-003091-uvfppirt	243	14	different	different	JJ
cord-003091-uvfppirt	243	15	from	from	IN
cord-003091-uvfppirt	243	16	the	the	DT
cord-003091-uvfppirt	243	17	self	self	NN
cord-003091-uvfppirt	243	18	-	-	HYPH
cord-003091-uvfppirt	243	19	tumor	tumor	NN
cord-003091-uvfppirt	243	20	ags	ag	NNS
cord-003091-uvfppirt	243	21	,	,	,
cord-003091-uvfppirt	243	22	derived	derive	VBN
cord-003091-uvfppirt	243	23	by	by	IN
cord-003091-uvfppirt	243	24	the	the	DT
cord-003091-uvfppirt	243	25	tumor	tumor	NN
cord-003091-uvfppirt	243	26	-	-	HYPH
cord-003091-uvfppirt	243	27	specific	specific	JJ
cord-003091-uvfppirt	243	28	mutations	mutation	NNS
cord-003091-uvfppirt	243	29	.	.	.
cord-003091-uvfppirt	244	1	Therefore	therefore	RB
cord-003091-uvfppirt	244	2	,	,	,
cord-003091-uvfppirt	244	3	prediction	prediction	NN
cord-003091-uvfppirt	244	4	tools	tool	NNS
cord-003091-uvfppirt	244	5	,	,	,
cord-003091-uvfppirt	244	6	RNA	RNA	NNP
cord-003091-uvfppirt	244	7	mutanome	mutanome	NNP
cord-003091-uvfppirt	244	8	,	,	,
cord-003091-uvfppirt	244	9	and	and	CC
cord-003091-uvfppirt	244	10	deep	deep	JJ
cord-003091-uvfppirt	244	11	-	-	HYPH
cord-003091-uvfppirt	244	12	sequencing	sequencing	NN
cord-003091-uvfppirt	244	13	have	have	VBP
cord-003091-uvfppirt	244	14	allowed	allow	VBN
cord-003091-uvfppirt	244	15	the	the	DT
cord-003091-uvfppirt	244	16	identification	identification	NN
cord-003091-uvfppirt	244	17	of	of	IN
cord-003091-uvfppirt	244	18	specific	specific	JJ
cord-003091-uvfppirt	244	19	non	non	JJ
cord-003091-uvfppirt	244	20	-	-	JJ
cord-003091-uvfppirt	244	21	self	self	JJ
cord-003091-uvfppirt	244	22	-	-	HYPH
cord-003091-uvfppirt	244	23	ags	ag	NNS
cord-003091-uvfppirt	244	24	that	that	WDT
cord-003091-uvfppirt	244	25	are	be	VBP
cord-003091-uvfppirt	244	26	fundamental	fundamental	JJ
cord-003091-uvfppirt	244	27	in	in	IN
cord-003091-uvfppirt	244	28	strong	strong	JJ
cord-003091-uvfppirt	244	29	T	t	NN
cord-003091-uvfppirt	244	30	cell	cell	NN
cord-003091-uvfppirt	244	31	immunity	immunity	NN
cord-003091-uvfppirt	244	32	(	(	-LRB-
cord-003091-uvfppirt	244	33	162	162	CD
cord-003091-uvfppirt	244	34	)	)	-RRB-
cord-003091-uvfppirt	244	35	(	(	-LRB-
cord-003091-uvfppirt	244	36	163	163	CD
cord-003091-uvfppirt	244	37	)	)	-RRB-
cord-003091-uvfppirt	244	38	(	(	-LRB-
cord-003091-uvfppirt	244	39	164	164	CD
cord-003091-uvfppirt	244	40	)	)	-RRB-
cord-003091-uvfppirt	244	41	.	.	.
cord-003091-uvfppirt	245	1	Indeed	indeed	RB
cord-003091-uvfppirt	245	2	,	,	,
cord-003091-uvfppirt	245	3	several	several	JJ
cord-003091-uvfppirt	245	4	clinical	clinical	JJ
cord-003091-uvfppirt	245	5	trials	trial	NNS
cord-003091-uvfppirt	245	6	are	be	VBP
cord-003091-uvfppirt	245	7	currently	currently	RB
cord-003091-uvfppirt	245	8	investigating	investigate	VBG
cord-003091-uvfppirt	245	9	the	the	DT
cord-003091-uvfppirt	245	10	potential	potential	NN
cord-003091-uvfppirt	245	11	of	of	IN
cord-003091-uvfppirt	245	12	neoantigens	neoantigen	NNS
cord-003091-uvfppirt	245	13	(	(	-LRB-
cord-003091-uvfppirt	245	14	NCT0235956	NCT0235956	NNP
cord-003091-uvfppirt	245	15	;	;	:
cord-003091-uvfppirt	245	16	NCT01970358	NCT01970358	NNP
cord-003091-uvfppirt	245	17	;	;	:
cord-003091-uvfppirt	245	18	NCT02149225	NCT02149225	NNP
cord-003091-uvfppirt	245	19	;	;	:
cord-003091-uvfppirt	245	20	NCT02348320	NCT02348320	NNP
cord-003091-uvfppirt	245	21	;	;	:
cord-003091-uvfppirt	245	22	NCT02316457	NCT02316457	NNP
cord-003091-uvfppirt	245	23	)	)	-RRB-
cord-003091-uvfppirt	245	24	.	.	.
cord-003091-uvfppirt	246	1	As	as	IN
cord-003091-uvfppirt	246	2	emerged	emerge	VBN
cord-003091-uvfppirt	246	3	,	,	,
cord-003091-uvfppirt	246	4	different	different	JJ
cord-003091-uvfppirt	246	5	strategies	strategy	NNS
cord-003091-uvfppirt	246	6	of	of	IN
cord-003091-uvfppirt	246	7	ags	ags	NNP
cord-003091-uvfppirt	246	8	selection	selection	NN
cord-003091-uvfppirt	246	9	have	have	VBP
cord-003091-uvfppirt	246	10	been	be	VBN
cord-003091-uvfppirt	246	11	explored	explore	VBN
cord-003091-uvfppirt	246	12	and	and	CC
cord-003091-uvfppirt	246	13	,	,	,
cord-003091-uvfppirt	246	14	even	even	RB
cord-003091-uvfppirt	246	15	though	though	IN
cord-003091-uvfppirt	246	16	one	one	CD
cord-003091-uvfppirt	246	17	strategy	strategy	NN
cord-003091-uvfppirt	246	18	may	may	MD
cord-003091-uvfppirt	246	19	result	result	VB
cord-003091-uvfppirt	246	20	in	in	IN
cord-003091-uvfppirt	246	21	a	a	DT
cord-003091-uvfppirt	246	22	more	more	RBR
cord-003091-uvfppirt	246	23	enforced	enforce	VBN
cord-003091-uvfppirt	246	24	antitumor	antitumor	JJ
cord-003091-uvfppirt	246	25	immunity	immunity	NN
cord-003091-uvfppirt	246	26	if	if	IN
cord-003091-uvfppirt	246	27	compared	compare	VBN
cord-003091-uvfppirt	246	28	to	to	IN
cord-003091-uvfppirt	246	29	another	another	DT
cord-003091-uvfppirt	246	30	,	,	,
cord-003091-uvfppirt	246	31	still	still	RB
cord-003091-uvfppirt	246	32	the	the	DT
cord-003091-uvfppirt	246	33	issue	issue	NN
cord-003091-uvfppirt	246	34	of	of	IN
cord-003091-uvfppirt	246	35	the	the	DT
cord-003091-uvfppirt	246	36	TME	TME	NNP
cord-003091-uvfppirt	246	37	negative	negative	JJ
cord-003091-uvfppirt	246	38	influence	influence	NN
cord-003091-uvfppirt	246	39	on	on	IN
cord-003091-uvfppirt	246	40	the	the	DT
cord-003091-uvfppirt	246	41	immune	immune	JJ
cord-003091-uvfppirt	246	42	system	system	NN
cord-003091-uvfppirt	246	43	has	have	VBZ
cord-003091-uvfppirt	246	44	to	to	TO
cord-003091-uvfppirt	246	45	be	be	VB
cord-003091-uvfppirt	246	46	faced	face	VBN
cord-003091-uvfppirt	246	47	.	.	.
cord-003091-uvfppirt	247	1	Indeed	indeed	RB
cord-003091-uvfppirt	247	2	,	,	,
cord-003091-uvfppirt	247	3	the	the	DT
cord-003091-uvfppirt	247	4	TME	TME	NNP
cord-003091-uvfppirt	247	5	actively	actively	RB
cord-003091-uvfppirt	247	6	suppresses	suppress	VBZ
cord-003091-uvfppirt	247	7	the	the	DT
cord-003091-uvfppirt	247	8	activation	activation	NN
cord-003091-uvfppirt	247	9	of	of	IN
cord-003091-uvfppirt	247	10	the	the	DT
cord-003091-uvfppirt	247	11	immune	immune	JJ
cord-003091-uvfppirt	247	12	system	system	NN
cord-003091-uvfppirt	247	13	.	.	.
cord-003091-uvfppirt	248	1	Tumor	tumor	NN
cord-003091-uvfppirt	248	2	cells	cell	NNS
cord-003091-uvfppirt	248	3	secrete	secrete	VBP
cord-003091-uvfppirt	248	4	immunosuppressive	immunosuppressive	JJ
cord-003091-uvfppirt	248	5	cytokines	cytokine	NNS
cord-003091-uvfppirt	248	6	,	,	,
cord-003091-uvfppirt	248	7	as	as	IN
cord-003091-uvfppirt	248	8	vascular	vascular	JJ
cord-003091-uvfppirt	248	9	endothelial	endothelial	JJ
cord-003091-uvfppirt	248	10	growth	growth	NN
cord-003091-uvfppirt	248	11	factor	factor	NN
cord-003091-uvfppirt	248	12	(	(	-LRB-
cord-003091-uvfppirt	248	13	165	165	CD
cord-003091-uvfppirt	248	14	,	,	,
cord-003091-uvfppirt	248	15	166	166	CD
cord-003091-uvfppirt	248	16	)	)	-RRB-
cord-003091-uvfppirt	248	17	,	,	,
cord-003091-uvfppirt	248	18	macrophage	macrophage	NN
cord-003091-uvfppirt	248	19	colony	colony	NN
cord-003091-uvfppirt	248	20	-	-	HYPH
cord-003091-uvfppirt	248	21	stimulating	stimulate	VBG
cord-003091-uvfppirt	248	22	factor	factor	NN
cord-003091-uvfppirt	248	23	(	(	-LRB-
cord-003091-uvfppirt	248	24	167	167	CD
cord-003091-uvfppirt	248	25	)	)	-RRB-
cord-003091-uvfppirt	248	26	,	,	,
cord-003091-uvfppirt	248	27	transforming	transform	VBG
cord-003091-uvfppirt	248	28	growth	growth	NN
cord-003091-uvfppirt	248	29	factor	factor	NN
cord-003091-uvfppirt	248	30	β	β	NN
cord-003091-uvfppirt	248	31	(	(	-LRB-
cord-003091-uvfppirt	248	32	TGF	TGF	NNP
cord-003091-uvfppirt	248	33	-	-	HYPH
cord-003091-uvfppirt	248	34	β	β	NNP
cord-003091-uvfppirt	248	35	)	)	-RRB-
cord-003091-uvfppirt	248	36	(	(	-LRB-
cord-003091-uvfppirt	248	37	168	168	CD
cord-003091-uvfppirt	248	38	)	)	-RRB-
cord-003091-uvfppirt	248	39	,	,	,
cord-003091-uvfppirt	248	40	and	and	CC
cord-003091-uvfppirt	248	41	IL-10	IL-10	NNP
cord-003091-uvfppirt	248	42	(	(	-LRB-
cord-003091-uvfppirt	248	43	169	169	CD
cord-003091-uvfppirt	248	44	,	,	,
cord-003091-uvfppirt	248	45	170	170	CD
cord-003091-uvfppirt	248	46	)	)	-RRB-
cord-003091-uvfppirt	248	47	.	.	.
cord-003091-uvfppirt	249	1	Even	even	RB
cord-003091-uvfppirt	249	2	though	though	IN
cord-003091-uvfppirt	249	3	some	some	DT
cord-003091-uvfppirt	249	4	of	of	IN
cord-003091-uvfppirt	249	5	these	these	DT
cord-003091-uvfppirt	249	6	cytokine	cytokine	NN
cord-003091-uvfppirt	249	7	display	display	NN
cord-003091-uvfppirt	249	8	controversial	controversial	JJ
cord-003091-uvfppirt	249	9	roles	role	NNS
cord-003091-uvfppirt	249	10	,	,	,
cord-003091-uvfppirt	249	11	depending	depend	VBG
cord-003091-uvfppirt	249	12	on	on	IN
cord-003091-uvfppirt	249	13	the	the	DT
cord-003091-uvfppirt	249	14	pathological	pathological	JJ
cord-003091-uvfppirt	249	15	context	context	NN
cord-003091-uvfppirt	249	16	,	,	,
cord-003091-uvfppirt	249	17	they	-PRON-	PRP
cord-003091-uvfppirt	249	18	generally	generally	RB
cord-003091-uvfppirt	249	19	promote	promote	VBP
cord-003091-uvfppirt	249	20	DCs	DCs	NNP
cord-003091-uvfppirt	249	21	tolerogenicity	tolerogenicity	NN
cord-003091-uvfppirt	249	22	,	,	,
cord-003091-uvfppirt	249	23	by	by	IN
cord-003091-uvfppirt	249	24	limiting	limit	VBG
cord-003091-uvfppirt	249	25	their	-PRON-	PRP$
cord-003091-uvfppirt	249	26	activation	activation	NN
cord-003091-uvfppirt	249	27	and	and	CC
cord-003091-uvfppirt	249	28	increasing	increase	VBG
cord-003091-uvfppirt	249	29	their	-PRON-	PRP$
cord-003091-uvfppirt	249	30	expression	expression	NN
cord-003091-uvfppirt	249	31	of	of	IN
cord-003091-uvfppirt	249	32	pro	pro	JJ
cord-003091-uvfppirt	249	33	-	-	JJ
cord-003091-uvfppirt	249	34	tumor	tumor	JJ
cord-003091-uvfppirt	249	35	molecules	molecule	NNS
cord-003091-uvfppirt	249	36	,	,	,
cord-003091-uvfppirt	249	37	such	such	JJ
cord-003091-uvfppirt	249	38	as	as	IN
cord-003091-uvfppirt	249	39	programmed	program	VBN
cord-003091-uvfppirt	249	40	cell	cell	NN
cord-003091-uvfppirt	249	41	death	death	NN
cord-003091-uvfppirt	249	42	1	1	CD
cord-003091-uvfppirt	249	43	(	(	-LRB-
cord-003091-uvfppirt	249	44	PD-1	PD-1	NNP
cord-003091-uvfppirt	249	45	)	)	-RRB-
cord-003091-uvfppirt	249	46	and	and	CC
cord-003091-uvfppirt	249	47	indoleamine	indoleamine	NNP
cord-003091-uvfppirt	249	48	2,3-dioxygenase	2,3-dioxygenase	CD
cord-003091-uvfppirt	249	49	(	(	-LRB-
cord-003091-uvfppirt	249	50	IDO	IDO	NNP
cord-003091-uvfppirt	249	51	)	)	-RRB-
cord-003091-uvfppirt	249	52	.	.	.
cord-003091-uvfppirt	250	1	Therefore	therefore	RB
cord-003091-uvfppirt	250	2	,	,	,
cord-003091-uvfppirt	250	3	tolerogenic	tolerogenic	NNP
cord-003091-uvfppirt	250	4	DCs	dc	NNS
cord-003091-uvfppirt	250	5	lead	lead	VBP
cord-003091-uvfppirt	250	6	to	to	IN
cord-003091-uvfppirt	250	7	T	t	NN
cord-003091-uvfppirt	250	8	cells	cell	NNS
cord-003091-uvfppirt	250	9	anergy	anergy	JJ
cord-003091-uvfppirt	250	10	,	,	,
cord-003091-uvfppirt	250	11	Tregs	Tregs	NNP
cord-003091-uvfppirt	250	12	expansion	expansion	NN
cord-003091-uvfppirt	250	13	,	,	,
cord-003091-uvfppirt	250	14	and	and	CC
cord-003091-uvfppirt	250	15	Th1	th1	NN
cord-003091-uvfppirt	250	16	responses	response	NNS
cord-003091-uvfppirt	250	17	inhibition	inhibition	NN
cord-003091-uvfppirt	250	18	.	.	.
cord-003091-uvfppirt	251	1	Phenotypical	phenotypical	JJ
cord-003091-uvfppirt	251	2	characterization	characterization	NN
cord-003091-uvfppirt	251	3	of	of	IN
cord-003091-uvfppirt	251	4	immune	immune	JJ
cord-003091-uvfppirt	251	5	cells	cell	NNS
cord-003091-uvfppirt	251	6	isolated	isolate	VBN
cord-003091-uvfppirt	251	7	from	from	IN
cord-003091-uvfppirt	251	8	breast	breast	NN
cord-003091-uvfppirt	251	9	cancer	cancer	NN
cord-003091-uvfppirt	251	10	patients	patient	NNS
cord-003091-uvfppirt	251	11	,	,	,
cord-003091-uvfppirt	251	12	highlighted	highlight	VBD
cord-003091-uvfppirt	251	13	the	the	DT
cord-003091-uvfppirt	251	14	functional	functional	JJ
cord-003091-uvfppirt	251	15	alteration	alteration	NN
cord-003091-uvfppirt	251	16	in	in	IN
cord-003091-uvfppirt	251	17	DCs	DCs	NNP
cord-003091-uvfppirt	251	18	,	,	,
cord-003091-uvfppirt	251	19	T	T	NNP
cord-003091-uvfppirt	251	20	,	,	,
cord-003091-uvfppirt	251	21	and	and	CC
cord-003091-uvfppirt	251	22	NK	NK	NNP
cord-003091-uvfppirt	251	23	cells	cell	NNS
cord-003091-uvfppirt	251	24	in	in	IN
cord-003091-uvfppirt	251	25	promoting	promote	VBG
cord-003091-uvfppirt	251	26	antitumor	antitumor	JJ
cord-003091-uvfppirt	251	27	responses	response	NNS
cord-003091-uvfppirt	251	28	(	(	-LRB-
cord-003091-uvfppirt	251	29	171	171	CD
cord-003091-uvfppirt	251	30	)	)	-RRB-
cord-003091-uvfppirt	251	31	.	.	.
cord-003091-uvfppirt	252	1	Furthermore	furthermore	RB
cord-003091-uvfppirt	252	2	,	,	,
cord-003091-uvfppirt	252	3	tumor	tumor	NN
cord-003091-uvfppirt	252	4	cells	cell	NNS
cord-003091-uvfppirt	252	5	retain	retain	VBP
cord-003091-uvfppirt	252	6	DCs	dc	NNS
cord-003091-uvfppirt	252	7	into	into	IN
cord-003091-uvfppirt	252	8	the	the	DT
cord-003091-uvfppirt	252	9	TME	TME	NNP
cord-003091-uvfppirt	252	10	,	,	,
cord-003091-uvfppirt	252	11	preventing	prevent	VBG
cord-003091-uvfppirt	252	12	their	-PRON-	PRP$
cord-003091-uvfppirt	252	13	migration	migration	NN
cord-003091-uvfppirt	252	14	to	to	IN
cord-003091-uvfppirt	252	15	draining	drain	VBG
cord-003091-uvfppirt	252	16	LNs	ln	NNS
cord-003091-uvfppirt	252	17	and	and	CC
cord-003091-uvfppirt	252	18	promoting	promote	VBG
cord-003091-uvfppirt	252	19	metastatization	metastatization	NN
cord-003091-uvfppirt	252	20	(	(	-LRB-
cord-003091-uvfppirt	252	21	172	172	CD
cord-003091-uvfppirt	252	22	)	)	-RRB-
cord-003091-uvfppirt	252	23	.	.	.
cord-003091-uvfppirt	253	1	To	to	TO
cord-003091-uvfppirt	253	2	address	address	VB
cord-003091-uvfppirt	253	3	this	this	DT
cord-003091-uvfppirt	253	4	issue	issue	NN
cord-003091-uvfppirt	253	5	,	,	,
cord-003091-uvfppirt	253	6	some	some	DT
cord-003091-uvfppirt	253	7	ex	ex	AFX
cord-003091-uvfppirt	253	8	vivo	vivo	NN
cord-003091-uvfppirt	253	9	generated	generate	VBD
cord-003091-uvfppirt	253	10	DCs	DCs	NNP
cord-003091-uvfppirt	253	11	-	-	HYPH
cord-003091-uvfppirt	253	12	based	base	VBN
cord-003091-uvfppirt	253	13	vaccines	vaccine	NNS
cord-003091-uvfppirt	253	14	are	be	VBP
cord-003091-uvfppirt	253	15	directly	directly	RB
cord-003091-uvfppirt	253	16	administered	administer	VBN
cord-003091-uvfppirt	253	17	intranodally	intranodally	RB
cord-003091-uvfppirt	253	18	,	,	,
cord-003091-uvfppirt	253	19	as	as	IN
cord-003091-uvfppirt	253	20	for	for	IN
cord-003091-uvfppirt	253	21	the	the	DT
cord-003091-uvfppirt	253	22	CD1c	CD1c	NNP
cord-003091-uvfppirt	253	23	+	+	CC
cord-003091-uvfppirt	253	24	DCs	dc	NNS
cord-003091-uvfppirt	253	25	pulsed	pulse	VBD
cord-003091-uvfppirt	253	26	with	with	IN
cord-003091-uvfppirt	253	27	HLA	HLA	NNP
cord-003091-uvfppirt	253	28	-	-	HYPH
cord-003091-uvfppirt	253	29	A2.1-restricted	a2.1-restricte	VBN
cord-003091-uvfppirt	253	30	tumor	tumor	NN
cord-003091-uvfppirt	253	31	peptides	peptide	NNS
cord-003091-uvfppirt	253	32	administered	administer	VBN
cord-003091-uvfppirt	253	33	to	to	IN
cord-003091-uvfppirt	253	34	patients	patient	NNS
cord-003091-uvfppirt	253	35	with	with	IN
cord-003091-uvfppirt	253	36	stage	stage	NN
cord-003091-uvfppirt	253	37	IV	IV	NNP
cord-003091-uvfppirt	253	38	melanoma	melanoma	NN
cord-003091-uvfppirt	253	39	(	(	-LRB-
cord-003091-uvfppirt	253	40	NCT01690377	NCT01690377	NNP
cord-003091-uvfppirt	253	41	)	)	-RRB-
cord-003091-uvfppirt	253	42	,	,	,
cord-003091-uvfppirt	253	43	which	which	WDT
cord-003091-uvfppirt	253	44	generated	generate	VBD
cord-003091-uvfppirt	253	45	tumor	tumor	NN
cord-003091-uvfppirt	253	46	-	-	HYPH
cord-003091-uvfppirt	253	47	specific	specific	JJ
cord-003091-uvfppirt	253	48	CD8	CD8	NNP
cord-003091-uvfppirt	253	49	+	+	CC
cord-003091-uvfppirt	253	50	T	T	NNP
cord-003091-uvfppirt	253	51	cells	cell	NNS
cord-003091-uvfppirt	253	52	responses	response	NNS
cord-003091-uvfppirt	253	53	and	and	CC
cord-003091-uvfppirt	253	54	further	further	JJ
cord-003091-uvfppirt	253	55	improvement	improvement	NN
cord-003091-uvfppirt	253	56	of	of	IN
cord-003091-uvfppirt	253	57	survival	survival	NN
cord-003091-uvfppirt	253	58	(	(	-LRB-
cord-003091-uvfppirt	253	59	173	173	CD
cord-003091-uvfppirt	253	60	)	)	-RRB-
cord-003091-uvfppirt	253	61	.	.	.
cord-003091-uvfppirt	254	1	To	to	TO
cord-003091-uvfppirt	254	2	reduce	reduce	VB
cord-003091-uvfppirt	254	3	the	the	DT
cord-003091-uvfppirt	254	4	tolerogenic	tolerogenic	JJ
cord-003091-uvfppirt	254	5	influence	influence	NN
cord-003091-uvfppirt	254	6	of	of	IN
cord-003091-uvfppirt	254	7	the	the	DT
cord-003091-uvfppirt	254	8	TME	TME	NNP
cord-003091-uvfppirt	254	9	on	on	IN
cord-003091-uvfppirt	254	10	DCs	dc	NNS
cord-003091-uvfppirt	254	11	,	,	,
cord-003091-uvfppirt	254	12	the	the	DT
cord-003091-uvfppirt	254	13	positive	positive	JJ
cord-003091-uvfppirt	254	14	role	role	NN
cord-003091-uvfppirt	254	15	of	of	IN
cord-003091-uvfppirt	254	16	GM	GM	NNP
cord-003091-uvfppirt	254	17	-	-	HYPH
cord-003091-uvfppirt	254	18	CSF	CSF	NNP
cord-003091-uvfppirt	254	19	in	in	IN
cord-003091-uvfppirt	254	20	improving	improve	VBG
cord-003091-uvfppirt	254	21	DCs	DCs	NNP
cord-003091-uvfppirt	254	22	survival	survival	NN
cord-003091-uvfppirt	254	23	and	and	CC
cord-003091-uvfppirt	254	24	responsiveness	responsiveness	NN
cord-003091-uvfppirt	254	25	is	be	VBZ
cord-003091-uvfppirt	254	26	currently	currently	RB
cord-003091-uvfppirt	254	27	exploited	exploit	VBN
cord-003091-uvfppirt	254	28	in	in	IN
cord-003091-uvfppirt	254	29	some	some	DT
cord-003091-uvfppirt	254	30	clinical	clinical	JJ
cord-003091-uvfppirt	254	31	trials	trial	NNS
cord-003091-uvfppirt	254	32	like	like	IN
cord-003091-uvfppirt	254	33	a	a	DT
cord-003091-uvfppirt	254	34	phase	phase	NN
cord-003091-uvfppirt	254	35	I	-PRON-	PRP
cord-003091-uvfppirt	254	36	/	/	SYM
cord-003091-uvfppirt	254	37	II	II	NNP
cord-003091-uvfppirt	254	38	trial	trial	NN
cord-003091-uvfppirt	254	39	with	with	IN
cord-003091-uvfppirt	254	40	a	a	DT
cord-003091-uvfppirt	254	41	DC	DC	NNP
cord-003091-uvfppirt	254	42	/	/	SYM
cord-003091-uvfppirt	254	43	tumor	tumor	NN
cord-003091-uvfppirt	254	44	cell	cell	NN
cord-003091-uvfppirt	254	45	fusion	fusion	NN
cord-003091-uvfppirt	254	46	vaccine	vaccine	NN
cord-003091-uvfppirt	254	47	administered	administer	VBN
cord-003091-uvfppirt	254	48	in	in	IN
cord-003091-uvfppirt	254	49	association	association	NN
cord-003091-uvfppirt	254	50	with	with	IN
cord-003091-uvfppirt	254	51	GM	GM	NNP
cord-003091-uvfppirt	254	52	-	-	HYPH
cord-003091-uvfppirt	254	53	CSF	CSF	NNP
cord-003091-uvfppirt	254	54	to	to	TO
cord-003091-uvfppirt	254	55	treat	treat	VB
cord-003091-uvfppirt	254	56	renal	renal	JJ
cord-003091-uvfppirt	254	57	cancer	cancer	NN
cord-003091-uvfppirt	254	58	(	(	-LRB-
cord-003091-uvfppirt	254	59	NCT00458536	NCT00458536	NNP
cord-003091-uvfppirt	254	60	)	)	-RRB-
cord-003091-uvfppirt	254	61	.	.	.
cord-003091-uvfppirt	255	1	Similarly	similarly	RB
cord-003091-uvfppirt	255	2	,	,	,
cord-003091-uvfppirt	255	3	others	other	NNS
cord-003091-uvfppirt	255	4	are	be	VBP
cord-003091-uvfppirt	255	5	focusing	focus	VBG
cord-003091-uvfppirt	255	6	their	-PRON-	PRP$
cord-003091-uvfppirt	255	7	attention	attention	NN
cord-003091-uvfppirt	255	8	on	on	IN
cord-003091-uvfppirt	255	9	FMS	FMS	NNP
cord-003091-uvfppirt	255	10	-	-	HYPH
cord-003091-uvfppirt	255	11	like	like	JJ
cord-003091-uvfppirt	255	12	tyrosine	tyrosine	NN
cord-003091-uvfppirt	255	13	kinase	kinase	NN
cord-003091-uvfppirt	255	14	3-ligand	3-ligand	CD
cord-003091-uvfppirt	255	15	(	(	-LRB-
cord-003091-uvfppirt	255	16	FLT3L	flt3l	CD
cord-003091-uvfppirt	255	17	)	)	-RRB-
cord-003091-uvfppirt	255	18	,	,	,
cord-003091-uvfppirt	255	19	another	another	DT
cord-003091-uvfppirt	255	20	crucial	crucial	JJ
cord-003091-uvfppirt	255	21	DCs	dcs	JJ
cord-003091-uvfppirt	255	22	growth	growth	NN
cord-003091-uvfppirt	255	23	factor	factor	NN
cord-003091-uvfppirt	255	24	,	,	,
cord-003091-uvfppirt	255	25	in	in	IN
cord-003091-uvfppirt	255	26	combination	combination	NN
cord-003091-uvfppirt	255	27	with	with	IN
cord-003091-uvfppirt	255	28	other	other	JJ
cord-003091-uvfppirt	255	29	compounds	compound	NNS
cord-003091-uvfppirt	255	30	(	(	-LRB-
cord-003091-uvfppirt	255	31	NCT01811992	NCT01811992	NNP
cord-003091-uvfppirt	255	32	;	;	:
cord-003091-uvfppirt	255	33	NCT01976585	NCT01976585	NNP
cord-003091-uvfppirt	255	34	;	;	:
cord-003091-uvfppirt	255	35	NCT02129075	NCT02129075	NNP
cord-003091-uvfppirt	255	36	;	;	:
cord-003091-uvfppirt	255	37	NCT02839265	NCT02839265	NNP
cord-003091-uvfppirt	255	38	)	)	-RRB-
cord-003091-uvfppirt	255	39	.	.	.
cord-003091-uvfppirt	256	1	FLT3L	FLT3L	NNP
cord-003091-uvfppirt	256	2	has	have	VBZ
cord-003091-uvfppirt	256	3	,	,	,
cord-003091-uvfppirt	256	4	indeed	indeed	RB
cord-003091-uvfppirt	256	5	,	,	,
cord-003091-uvfppirt	256	6	been	be	VBN
cord-003091-uvfppirt	256	7	shown	show	VBN
cord-003091-uvfppirt	256	8	to	to	TO
cord-003091-uvfppirt	256	9	increase	increase	VB
cord-003091-uvfppirt	256	10	the	the	DT
cord-003091-uvfppirt	256	11	efficacy	efficacy	NN
cord-003091-uvfppirt	256	12	of	of	IN
cord-003091-uvfppirt	256	13	proteins	protein	NNS
cord-003091-uvfppirt	256	14	-	-	:
cord-003091-uvfppirt	256	15	and	and	CC
cord-003091-uvfppirt	256	16	RNA	RNA	NNP
cord-003091-uvfppirt	256	17	-	-	HYPH
cord-003091-uvfppirt	256	18	based	base	VBN
cord-003091-uvfppirt	256	19	vaccines	vaccine	NNS
cord-003091-uvfppirt	256	20	,	,	,
cord-003091-uvfppirt	256	21	due	due	IN
cord-003091-uvfppirt	256	22	to	to	IN
cord-003091-uvfppirt	256	23	a	a	DT
cord-003091-uvfppirt	256	24	maturation	maturation	NN
cord-003091-uvfppirt	256	25	effect	effect	NN
cord-003091-uvfppirt	256	26	on	on	IN
cord-003091-uvfppirt	256	27	DCs	DCs	NNP
cord-003091-uvfppirt	256	28	(	(	-LRB-
cord-003091-uvfppirt	256	29	174	174	CD
cord-003091-uvfppirt	256	30	)	)	-RRB-
cord-003091-uvfppirt	256	31	(	(	-LRB-
cord-003091-uvfppirt	256	32	175	175	CD
cord-003091-uvfppirt	256	33	)	)	-RRB-
cord-003091-uvfppirt	256	34	(	(	-LRB-
cord-003091-uvfppirt	256	35	176	176	CD
cord-003091-uvfppirt	256	36	)	)	-RRB-
cord-003091-uvfppirt	256	37	.	.	.
cord-003091-uvfppirt	257	1	Additional	additional	JJ
cord-003091-uvfppirt	257	2	efforts	effort	NNS
cord-003091-uvfppirt	257	3	made	make	VBN
cord-003091-uvfppirt	257	4	to	to	TO
cord-003091-uvfppirt	257	5	counteract	counteract	VB
cord-003091-uvfppirt	257	6	the	the	DT
cord-003091-uvfppirt	257	7	tolerogenic	tolerogenic	JJ
cord-003091-uvfppirt	257	8	influence	influence	NN
cord-003091-uvfppirt	257	9	of	of	IN
cord-003091-uvfppirt	257	10	the	the	DT
cord-003091-uvfppirt	257	11	TME	TME	NNP
cord-003091-uvfppirt	257	12	include	include	VBP
cord-003091-uvfppirt	257	13	the	the	DT
cord-003091-uvfppirt	257	14	use	use	NN
cord-003091-uvfppirt	257	15	of	of	IN
cord-003091-uvfppirt	257	16	PD-1	PD-1	NNP
cord-003091-uvfppirt	257	17	and	and	CC
cord-003091-uvfppirt	257	18	IDO	IDO	NNP
cord-003091-uvfppirt	257	19	inhibitors	inhibitor	NNS
cord-003091-uvfppirt	257	20	.	.	.
cord-003091-uvfppirt	258	1	Co	Co	NNP
cord-003091-uvfppirt	258	2	-	-	NN
cord-003091-uvfppirt	258	3	administration	administration	NN
cord-003091-uvfppirt	258	4	of	of	IN
cord-003091-uvfppirt	258	5	anti	anti	JJ
cord-003091-uvfppirt	258	6	-	-	JJ
cord-003091-uvfppirt	258	7	PD-1	pd-1	JJ
cord-003091-uvfppirt	258	8	molecules	molecule	NNS
cord-003091-uvfppirt	258	9	increases	increase	VBZ
cord-003091-uvfppirt	258	10	the	the	DT
cord-003091-uvfppirt	258	11	efficacy	efficacy	NN
cord-003091-uvfppirt	258	12	of	of	IN
cord-003091-uvfppirt	258	13	DCs	DCs	NNP
cord-003091-uvfppirt	258	14	-	-	HYPH
cord-003091-uvfppirt	258	15	based	base	VBN
cord-003091-uvfppirt	258	16	vaccines	vaccine	NNS
cord-003091-uvfppirt	258	17	,	,	,
cord-003091-uvfppirt	258	18	in	in	IN
cord-003091-uvfppirt	258	19	terms	term	NNS
cord-003091-uvfppirt	258	20	of	of	IN
cord-003091-uvfppirt	258	21	enforced	enforce	VBN
cord-003091-uvfppirt	258	22	intratumoral	intratumoral	JJ
cord-003091-uvfppirt	258	23	CD8	CD8	NNP
cord-003091-uvfppirt	258	24	+	+	CC
cord-003091-uvfppirt	258	25	T	T	NNP
cord-003091-uvfppirt	258	26	cell	cell	NN
cord-003091-uvfppirt	258	27	responses	response	NNS
cord-003091-uvfppirt	258	28	and	and	CC
cord-003091-uvfppirt	258	29	trafficking	trafficking	NN
cord-003091-uvfppirt	258	30	of	of	IN
cord-003091-uvfppirt	258	31	CD8	CD8	NNP
cord-003091-uvfppirt	258	32	+	+	SYM
cord-003091-uvfppirt	258	33	memory	memory	NN
cord-003091-uvfppirt	258	34	T	T	NNP
cord-003091-uvfppirt	258	35	cells	cell	NNS
cord-003091-uvfppirt	258	36	,	,	,
cord-003091-uvfppirt	258	37	as	as	IN
cord-003091-uvfppirt	258	38	observed	observe	VBN
cord-003091-uvfppirt	258	39	in	in	IN
cord-003091-uvfppirt	258	40	a	a	DT
cord-003091-uvfppirt	258	41	preclinical	preclinical	JJ
cord-003091-uvfppirt	258	42	model	model	NN
cord-003091-uvfppirt	258	43	of	of	IN
cord-003091-uvfppirt	258	44	glioblastoma	glioblastoma	NN
cord-003091-uvfppirt	258	45	(	(	-LRB-
cord-003091-uvfppirt	258	46	177	177	CD
cord-003091-uvfppirt	258	47	)	)	-RRB-
cord-003091-uvfppirt	258	48	.	.	.
cord-003091-uvfppirt	259	1	In	in	IN
cord-003091-uvfppirt	259	2	parallel	parallel	JJ
cord-003091-uvfppirt	259	3	,	,	,
cord-003091-uvfppirt	259	4	several	several	JJ
cord-003091-uvfppirt	259	5	clinical	clinical	JJ
cord-003091-uvfppirt	259	6	trials	trial	NNS
cord-003091-uvfppirt	259	7	are	be	VBP
cord-003091-uvfppirt	259	8	aiming	aim	VBG
cord-003091-uvfppirt	259	9	at	at	IN
cord-003091-uvfppirt	259	10	evaluating	evaluate	VBG
cord-003091-uvfppirt	259	11	the	the	DT
cord-003091-uvfppirt	259	12	efficacy	efficacy	NN
cord-003091-uvfppirt	259	13	of	of	IN
cord-003091-uvfppirt	259	14	DCs	DCs	NNP
cord-003091-uvfppirt	259	15	-	-	HYPH
cord-003091-uvfppirt	259	16	based	base	VBN
cord-003091-uvfppirt	259	17	vaccines	vaccine	NNS
cord-003091-uvfppirt	259	18	combined	combine	VBN
cord-003091-uvfppirt	259	19	with	with	IN
cord-003091-uvfppirt	259	20	anti	anti	JJ
cord-003091-uvfppirt	259	21	-	-	JJ
cord-003091-uvfppirt	259	22	PD-1	pd-1	JJ
cord-003091-uvfppirt	259	23	agents	agent	NNS
cord-003091-uvfppirt	259	24	(	(	-LRB-
cord-003091-uvfppirt	259	25	NCT03014804	NCT03014804	NNP
cord-003091-uvfppirt	259	26	;	;	:
cord-003091-uvfppirt	259	27	NCT03325101	NCT03325101	NNP
cord-003091-uvfppirt	259	28	;	;	:
cord-003091-uvfppirt	259	29	NCT03035331	NCT03035331	NNP
cord-003091-uvfppirt	259	30	)	)	-RRB-
cord-003091-uvfppirt	259	31	.	.	.
cord-003091-uvfppirt	260	1	The	the	DT
cord-003091-uvfppirt	260	2	other	other	JJ
cord-003091-uvfppirt	260	3	tolerogenic	tolerogenic	NNP
cord-003091-uvfppirt	260	4	marker	marker	NN
cord-003091-uvfppirt	260	5	addressed	address	VBN
cord-003091-uvfppirt	260	6	in	in	IN
cord-003091-uvfppirt	260	7	cancer	cancer	NN
cord-003091-uvfppirt	260	8	immunotherapy	immunotherapy	NN
cord-003091-uvfppirt	260	9	and	and	CC
cord-003091-uvfppirt	260	10	DCs	DCs	NNP
cord-003091-uvfppirt	260	11	-	-	HYPH
cord-003091-uvfppirt	260	12	based	base	VBN
cord-003091-uvfppirt	260	13	vaccine	vaccine	NN
cord-003091-uvfppirt	260	14	is	be	VBZ
cord-003091-uvfppirt	260	15	IDO	IDO	NNP
cord-003091-uvfppirt	260	16	.	.	.
cord-003091-uvfppirt	261	1	Indeed	indeed	RB
cord-003091-uvfppirt	261	2	,	,	,
cord-003091-uvfppirt	261	3	silencing	silence	VBG
cord-003091-uvfppirt	261	4	approaches	approach	NNS
cord-003091-uvfppirt	261	5	to	to	TO
cord-003091-uvfppirt	261	6	reduce	reduce	VB
cord-003091-uvfppirt	261	7	the	the	DT
cord-003091-uvfppirt	261	8	expression	expression	NN
cord-003091-uvfppirt	261	9	of	of	IN
cord-003091-uvfppirt	261	10	IDO	IDO	NNP
cord-003091-uvfppirt	261	11	in	in	IN
cord-003091-uvfppirt	261	12	DCs	DCs	NNP
cord-003091-uvfppirt	261	13	for	for	IN
cord-003091-uvfppirt	261	14	vaccination	vaccination	NN
cord-003091-uvfppirt	261	15	in	in	IN
cord-003091-uvfppirt	261	16	preclinical	preclinical	JJ
cord-003091-uvfppirt	261	17	models	model	NNS
cord-003091-uvfppirt	261	18	,	,	,
cord-003091-uvfppirt	261	19	have	have	VBP
cord-003091-uvfppirt	261	20	resulted	result	VBN
cord-003091-uvfppirt	261	21	in	in	IN
cord-003091-uvfppirt	261	22	decreased	decrease	VBN
cord-003091-uvfppirt	261	23	T	t	NN
cord-003091-uvfppirt	261	24	cell	cell	NN
cord-003091-uvfppirt	261	25	apoptosis	apoptosis	NN
cord-003091-uvfppirt	261	26	,	,	,
cord-003091-uvfppirt	261	27	reduced	reduce	VBN
cord-003091-uvfppirt	261	28	numbers	number	NNS
cord-003091-uvfppirt	261	29	of	of	IN
cord-003091-uvfppirt	261	30	Tregs	Tregs	NNP
cord-003091-uvfppirt	261	31	,	,	,
cord-003091-uvfppirt	261	32	decreased	decrease	VBD
cord-003091-uvfppirt	261	33	tumor	tumor	NN
cord-003091-uvfppirt	261	34	size	size	NN
cord-003091-uvfppirt	261	35	when	when	WRB
cord-003091-uvfppirt	261	36	compared	compare	VBN
cord-003091-uvfppirt	261	37	to	to	IN
cord-003091-uvfppirt	261	38	mice	mouse	NNS
cord-003091-uvfppirt	261	39	that	that	WDT
cord-003091-uvfppirt	261	40	had	have	VBD
cord-003091-uvfppirt	261	41	received	receive	VBN
cord-003091-uvfppirt	261	42	ags	ags	NNP
cord-003091-uvfppirt	261	43	-	-	HYPH
cord-003091-uvfppirt	261	44	loaded	load	VBN
cord-003091-uvfppirt	261	45	DCs	dc	NNS
cord-003091-uvfppirt	261	46	without	without	IN
cord-003091-uvfppirt	261	47	IDO	IDO	NNP
cord-003091-uvfppirt	261	48	silencing	silence	VBG
cord-003091-uvfppirt	261	49	(	(	-LRB-
cord-003091-uvfppirt	261	50	178	178	CD
cord-003091-uvfppirt	261	51	)	)	-RRB-
cord-003091-uvfppirt	261	52	.	.	.
cord-003091-uvfppirt	262	1	IDO	IDO	NNP
cord-003091-uvfppirt	262	2	inhibitors	inhibitor	NNS
cord-003091-uvfppirt	262	3	in	in	IN
cord-003091-uvfppirt	262	4	DCs	DCs	NNP
cord-003091-uvfppirt	262	5	vaccination	vaccination	NN
cord-003091-uvfppirt	262	6	are	be	VBP
cord-003091-uvfppirt	262	7	currently	currently	RB
cord-003091-uvfppirt	262	8	being	be	VBG
cord-003091-uvfppirt	262	9	tested	test	VBN
cord-003091-uvfppirt	262	10	in	in	IN
cord-003091-uvfppirt	262	11	phase	phase	NN
cord-003091-uvfppirt	262	12	II	ii	CD
cord-003091-uvfppirt	262	13	clinical	clinical	JJ
cord-003091-uvfppirt	262	14	trials	trial	NNS
cord-003091-uvfppirt	262	15	(	(	-LRB-
cord-003091-uvfppirt	263	1	NCT01560923	NCT01560923	NNP
cord-003091-uvfppirt	263	2	;	;	:
cord-003091-uvfppirt	263	3	NCT01042535	NCT01042535	NNP
cord-003091-uvfppirt	263	4	)	)	-RRB-
cord-003091-uvfppirt	263	5	.	.	.
cord-003091-uvfppirt	264	1	All	all	PDT
cord-003091-uvfppirt	264	2	these	these	DT
cord-003091-uvfppirt	264	3	approaches	approach	NNS
cord-003091-uvfppirt	264	4	have	have	VBP
cord-003091-uvfppirt	264	5	explored	explore	VBN
cord-003091-uvfppirt	264	6	different	different	JJ
cord-003091-uvfppirt	264	7	scenarios	scenario	NNS
cord-003091-uvfppirt	264	8	to	to	TO
cord-003091-uvfppirt	264	9	evaluate	evaluate	VB
cord-003091-uvfppirt	264	10	the	the	DT
cord-003091-uvfppirt	264	11	more	more	RBR
cord-003091-uvfppirt	264	12	efficient	efficient	JJ
cord-003091-uvfppirt	264	13	therapeutic	therapeutic	JJ
cord-003091-uvfppirt	264	14	combination	combination	NN
cord-003091-uvfppirt	264	15	that	that	WDT
cord-003091-uvfppirt	264	16	seems	seem	VBZ
cord-003091-uvfppirt	264	17	to	to	TO
cord-003091-uvfppirt	264	18	move	move	VB
cord-003091-uvfppirt	264	19	toward	toward	IN
cord-003091-uvfppirt	264	20	personalized	personalized	JJ
cord-003091-uvfppirt	264	21	vaccinations	vaccination	NNS
cord-003091-uvfppirt	264	22	for	for	IN
cord-003091-uvfppirt	264	23	cancer	cancer	NN
cord-003091-uvfppirt	264	24	patients	patient	NNS
cord-003091-uvfppirt	264	25	.	.	.
cord-003091-uvfppirt	265	1	In	in	IN
cord-003091-uvfppirt	265	2	this	this	DT
cord-003091-uvfppirt	265	3	review	review	NN
cord-003091-uvfppirt	265	4	,	,	,
cord-003091-uvfppirt	265	5	we	-PRON-	PRP
cord-003091-uvfppirt	265	6	have	have	VBP
cord-003091-uvfppirt	265	7	underscored	underscore	VBN
cord-003091-uvfppirt	265	8	the	the	DT
cord-003091-uvfppirt	265	9	crucial	crucial	JJ
cord-003091-uvfppirt	265	10	role	role	NN
cord-003091-uvfppirt	265	11	of	of	IN
cord-003091-uvfppirt	265	12	DCs	DCs	NNP
cord-003091-uvfppirt	265	13	in	in	IN
cord-003091-uvfppirt	265	14	orchestrating	orchestrate	VBG
cord-003091-uvfppirt	265	15	immune	immune	JJ
cord-003091-uvfppirt	265	16	responses	response	NNS
cord-003091-uvfppirt	265	17	and	and	CC
cord-003091-uvfppirt	265	18	;	;	:
cord-003091-uvfppirt	265	19	therefore	therefore	RB
cord-003091-uvfppirt	265	20	,	,	,
cord-003091-uvfppirt	265	21	the	the	DT
cord-003091-uvfppirt	265	22	great	great	JJ
cord-003091-uvfppirt	265	23	interest	interest	NN
cord-003091-uvfppirt	265	24	in	in	IN
cord-003091-uvfppirt	265	25	targeting	target	VBG
cord-003091-uvfppirt	265	26	these	these	DT
cord-003091-uvfppirt	265	27	cells	cell	NNS
cord-003091-uvfppirt	265	28	in	in	IN
cord-003091-uvfppirt	265	29	novel	novel	JJ
cord-003091-uvfppirt	265	30	vaccination	vaccination	NN
cord-003091-uvfppirt	265	31	strategies	strategy	NNS
cord-003091-uvfppirt	265	32	.	.	.
cord-003091-uvfppirt	266	1	We	-PRON-	PRP
cord-003091-uvfppirt	266	2	have	have	VBP
cord-003091-uvfppirt	266	3	reported	report	VBN
cord-003091-uvfppirt	266	4	examples	example	NNS
cord-003091-uvfppirt	266	5	of	of	IN
cord-003091-uvfppirt	266	6	different	different	JJ
cord-003091-uvfppirt	266	7	approaches	approach	NNS
cord-003091-uvfppirt	266	8	aimed	aim	VBN
cord-003091-uvfppirt	266	9	at	at	IN
cord-003091-uvfppirt	266	10	amplifying	amplify	VBG
cord-003091-uvfppirt	266	11	the	the	DT
cord-003091-uvfppirt	266	12	efficiency	efficiency	NN
cord-003091-uvfppirt	266	13	of	of	IN
cord-003091-uvfppirt	266	14	immunizations	immunization	NNS
cord-003091-uvfppirt	266	15	against	against	IN
cord-003091-uvfppirt	266	16	cancer	cancer	NN
cord-003091-uvfppirt	266	17	or	or	CC
cord-003091-uvfppirt	266	18	infectious	infectious	JJ
cord-003091-uvfppirt	266	19	diseases	disease	NNS
cord-003091-uvfppirt	266	20	.	.	.
cord-003091-uvfppirt	267	1	Indeed	indeed	RB
cord-003091-uvfppirt	267	2	,	,	,
cord-003091-uvfppirt	267	3	the	the	DT
cord-003091-uvfppirt	267	4	urgent	urgent	JJ
cord-003091-uvfppirt	267	5	need	need	NN
cord-003091-uvfppirt	267	6	of	of	IN
cord-003091-uvfppirt	267	7	vaccines	vaccine	NNS
cord-003091-uvfppirt	267	8	is	be	VBZ
cord-003091-uvfppirt	267	9	as	as	RB
cord-003091-uvfppirt	267	10	relevant	relevant	JJ
cord-003091-uvfppirt	267	11	as	as	IN
cord-003091-uvfppirt	267	12	before	before	IN
cord-003091-uvfppirt	267	13	because	because	IN
cord-003091-uvfppirt	267	14	of	of	IN
cord-003091-uvfppirt	267	15	newly	newly	RB
cord-003091-uvfppirt	267	16	emerging	emerge	VBG
cord-003091-uvfppirt	267	17	diseases	disease	NNS
cord-003091-uvfppirt	267	18	with	with	IN
cord-003091-uvfppirt	267	19	ineffective	ineffective	JJ
cord-003091-uvfppirt	267	20	current	current	JJ
cord-003091-uvfppirt	267	21	therapies	therapy	NNS
cord-003091-uvfppirt	267	22	.	.	.
cord-003091-uvfppirt	268	1	Deepen	deepen	VB
cord-003091-uvfppirt	268	2	the	the	DT
cord-003091-uvfppirt	268	3	mechanisms	mechanism	NNS
cord-003091-uvfppirt	268	4	underlying	underlie	VBG
cord-003091-uvfppirt	268	5	these	these	DT
cord-003091-uvfppirt	268	6	pathologies	pathology	NNS
cord-003091-uvfppirt	268	7	may	may	MD
cord-003091-uvfppirt	268	8	provide	provide	VB
cord-003091-uvfppirt	268	9	cues	cue	NNS
cord-003091-uvfppirt	268	10	on	on	IN
cord-003091-uvfppirt	268	11	the	the	DT
cord-003091-uvfppirt	268	12	more	more	RBR
cord-003091-uvfppirt	268	13	appropriate	appropriate	JJ
cord-003091-uvfppirt	268	14	design	design	NN
cord-003091-uvfppirt	268	15	of	of	IN
cord-003091-uvfppirt	268	16	vaccines	vaccine	NNS
cord-003091-uvfppirt	268	17	and	and	CC
cord-003091-uvfppirt	268	18	by	by	IN
cord-003091-uvfppirt	268	19	merging	merge	VBG
cord-003091-uvfppirt	268	20	diverse	diverse	JJ
cord-003091-uvfppirt	268	21	tailoring	tailoring	NN
cord-003091-uvfppirt	268	22	strategies	strategy	NNS
cord-003091-uvfppirt	268	23	we	-PRON-	PRP
cord-003091-uvfppirt	268	24	could	could	MD
cord-003091-uvfppirt	268	25	enforce	enforce	VB
cord-003091-uvfppirt	268	26	the	the	DT
cord-003091-uvfppirt	268	27	immune	immune	JJ
cord-003091-uvfppirt	268	28	system	system	NN
cord-003091-uvfppirt	268	29	.	.	.
cord-003091-uvfppirt	269	1	As	as	IN
cord-003091-uvfppirt	269	2	a	a	DT
cord-003091-uvfppirt	269	3	matter	matter	NN
cord-003091-uvfppirt	269	4	of	of	IN
cord-003091-uvfppirt	269	5	fact	fact	NN
cord-003091-uvfppirt	269	6	,	,	,
cord-003091-uvfppirt	269	7	it	-PRON-	PRP
cord-003091-uvfppirt	269	8	is	be	VBZ
cord-003091-uvfppirt	269	9	suggested	suggest	VBN
cord-003091-uvfppirt	269	10	to	to	TO
cord-003091-uvfppirt	269	11	act	act	VB
cord-003091-uvfppirt	269	12	on	on	IN
cord-003091-uvfppirt	269	13	different	different	JJ
cord-003091-uvfppirt	269	14	fronts	front	NNS
cord-003091-uvfppirt	269	15	when	when	WRB
cord-003091-uvfppirt	269	16	designing	design	VBG
cord-003091-uvfppirt	269	17	new	new	JJ
cord-003091-uvfppirt	269	18	vaccines	vaccine	NNS
cord-003091-uvfppirt	269	19	,	,	,
cord-003091-uvfppirt	269	20	since	since	IN
cord-003091-uvfppirt	269	21	several	several	JJ
cord-003091-uvfppirt	269	22	factors	factor	NNS
cord-003091-uvfppirt	269	23	must	must	MD
cord-003091-uvfppirt	269	24	be	be	VB
cord-003091-uvfppirt	269	25	considered	consider	VBN
cord-003091-uvfppirt	269	26	:	:	:
cord-003091-uvfppirt	269	27	(	(	-LRB-
cord-003091-uvfppirt	269	28	i	i	NN
cord-003091-uvfppirt	269	29	)	)	-RRB-
cord-003091-uvfppirt	269	30	targeting	target	VBG
cord-003091-uvfppirt	269	31	DC	DC	NNP
cord-003091-uvfppirt	269	32	subsets	subset	NNS
cord-003091-uvfppirt	269	33	specialized	specialize	VBN
cord-003091-uvfppirt	269	34	in	in	IN
cord-003091-uvfppirt	269	35	initiating	initiate	VBG
cord-003091-uvfppirt	269	36	the	the	DT
cord-003091-uvfppirt	269	37	desired	desire	VBN
cord-003091-uvfppirt	269	38	cellular	cellular	JJ
cord-003091-uvfppirt	269	39	or	or	CC
cord-003091-uvfppirt	269	40	humoral	humoral	JJ
cord-003091-uvfppirt	269	41	immunity	immunity	NN
cord-003091-uvfppirt	269	42	/	/	SYM
cord-003091-uvfppirt	269	43	memory	memory	NN
cord-003091-uvfppirt	269	44	;	;	,
cord-003091-uvfppirt	269	45	(	(	-LRB-
cord-003091-uvfppirt	269	46	ii	ii	NN
cord-003091-uvfppirt	269	47	)	)	-RRB-
cord-003091-uvfppirt	269	48	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	269	49	that	that	WDT
cord-003091-uvfppirt	269	50	strengthen	strengthen	VBP
cord-003091-uvfppirt	269	51	and	and	CC
cord-003091-uvfppirt	269	52	drive	drive	VB
cord-003091-uvfppirt	269	53	T	T	NNP
cord-003091-uvfppirt	269	54	and	and	CC
cord-003091-uvfppirt	269	55	B	b	NN
cord-003091-uvfppirt	269	56	cell	cell	NN
cord-003091-uvfppirt	269	57	responses	response	NNS
cord-003091-uvfppirt	269	58	;	;	,
cord-003091-uvfppirt	269	59	(	(	-LRB-
cord-003091-uvfppirt	269	60	iii	iii	NN
cord-003091-uvfppirt	269	61	)	)	-RRB-
cord-003091-uvfppirt	269	62	fine	fine	JJ
cord-003091-uvfppirt	269	63	and	and	CC
cord-003091-uvfppirt	269	64	optimized	optimized	JJ
cord-003091-uvfppirt	269	65	selection	selection	NN
cord-003091-uvfppirt	269	66	of	of	IN
cord-003091-uvfppirt	269	67	the	the	DT
cord-003091-uvfppirt	269	68	immunogenic	immunogenic	JJ
cord-003091-uvfppirt	269	69	ags	ag	NNS
cord-003091-uvfppirt	269	70	to	to	TO
cord-003091-uvfppirt	269	71	drive	drive	VB
cord-003091-uvfppirt	269	72	enforced	enforce	VBN
cord-003091-uvfppirt	269	73	responses	response	NNS
cord-003091-uvfppirt	269	74	;	;	,
cord-003091-uvfppirt	269	75	(	(	-LRB-
cord-003091-uvfppirt	269	76	iv	iv	LS
cord-003091-uvfppirt	269	77	)	)	-RRB-
cord-003091-uvfppirt	269	78	novel	novel	JJ
cord-003091-uvfppirt	269	79	strategies	strategy	NNS
cord-003091-uvfppirt	269	80	to	to	TO
cord-003091-uvfppirt	269	81	convey	convey	VB
cord-003091-uvfppirt	269	82	ags	ag	NNS
cord-003091-uvfppirt	269	83	and	and	CC
cord-003091-uvfppirt	269	84	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	269	85	to	to	IN
cord-003091-uvfppirt	269	86	DCs	DCs	NNP
cord-003091-uvfppirt	269	87	;	;	,
cord-003091-uvfppirt	269	88	(	(	-LRB-
cord-003091-uvfppirt	269	89	v	v	NN
cord-003091-uvfppirt	269	90	)	)	-RRB-
cord-003091-uvfppirt	269	91	route	route	NN
cord-003091-uvfppirt	269	92	of	of	IN
cord-003091-uvfppirt	269	93	administration	administration	NN
cord-003091-uvfppirt	269	94	.	.	.
cord-003091-uvfppirt	270	1	Starting	start	VBG
cord-003091-uvfppirt	270	2	from	from	IN
cord-003091-uvfppirt	270	3	these	these	DT
cord-003091-uvfppirt	270	4	notions	notion	NNS
cord-003091-uvfppirt	270	5	,	,	,
cord-003091-uvfppirt	270	6	in	in	IN
cord-003091-uvfppirt	270	7	the	the	DT
cord-003091-uvfppirt	270	8	last	last	JJ
cord-003091-uvfppirt	270	9	decades	decade	NNS
cord-003091-uvfppirt	270	10	,	,	,
cord-003091-uvfppirt	270	11	enormous	enormous	JJ
cord-003091-uvfppirt	270	12	efforts	effort	NNS
cord-003091-uvfppirt	270	13	have	have	VBP
cord-003091-uvfppirt	270	14	been	be	VBN
cord-003091-uvfppirt	270	15	made	make	VBN
cord-003091-uvfppirt	270	16	to	to	TO
cord-003091-uvfppirt	270	17	tailor	tailor	VB
cord-003091-uvfppirt	270	18	vaccination	vaccination	NN
cord-003091-uvfppirt	270	19	strategies	strategy	NNS
cord-003091-uvfppirt	270	20	.	.	.
cord-003091-uvfppirt	271	1	New	new	JJ
cord-003091-uvfppirt	271	2	technologies	technology	NNS
cord-003091-uvfppirt	271	3	as	as	RB
cord-003091-uvfppirt	271	4	well	well	RB
cord-003091-uvfppirt	271	5	as	as	IN
cord-003091-uvfppirt	271	6	recent	recent	JJ
cord-003091-uvfppirt	271	7	advances	advance	NNS
cord-003091-uvfppirt	271	8	have	have	VBP
cord-003091-uvfppirt	271	9	allowed	allow	VBN
cord-003091-uvfppirt	271	10	extreme	extreme	JJ
cord-003091-uvfppirt	271	11	flexibility	flexibility	NN
cord-003091-uvfppirt	271	12	in	in	IN
cord-003091-uvfppirt	271	13	designing	design	VBG
cord-003091-uvfppirt	271	14	vaccines	vaccine	NNS
cord-003091-uvfppirt	271	15	and	and	CC
cord-003091-uvfppirt	271	16	shaping	shape	VBG
cord-003091-uvfppirt	271	17	the	the	DT
cord-003091-uvfppirt	271	18	following	follow	VBG
cord-003091-uvfppirt	271	19	outcomes	outcome	NNS
cord-003091-uvfppirt	271	20	.	.	.
cord-003091-uvfppirt	272	1	Nowadays	nowadays	RB
cord-003091-uvfppirt	272	2	,	,	,
cord-003091-uvfppirt	272	3	researchers	researcher	NNS
cord-003091-uvfppirt	272	4	do	do	VBP
cord-003091-uvfppirt	272	5	have	have	VB
cord-003091-uvfppirt	272	6	smart	smart	JJ
cord-003091-uvfppirt	272	7	tools	tool	NNS
cord-003091-uvfppirt	272	8	to	to	TO
cord-003091-uvfppirt	272	9	manipulate	manipulate	VB
cord-003091-uvfppirt	272	10	immune	immune	JJ
cord-003091-uvfppirt	272	11	responses	response	NNS
cord-003091-uvfppirt	272	12	with	with	IN
cord-003091-uvfppirt	272	13	prophylactic	prophylactic	JJ
cord-003091-uvfppirt	272	14	or	or	CC
cord-003091-uvfppirt	272	15	therapeutic	therapeutic	JJ
cord-003091-uvfppirt	272	16	vaccinations	vaccination	NNS
cord-003091-uvfppirt	272	17	.	.	.
cord-003091-uvfppirt	273	1	The	the	DT
cord-003091-uvfppirt	273	2	abovementioned	abovementioned	JJ
cord-003091-uvfppirt	273	3	findings	finding	NNS
cord-003091-uvfppirt	273	4	pave	pave	VBP
cord-003091-uvfppirt	273	5	the	the	DT
cord-003091-uvfppirt	273	6	way	way	NN
cord-003091-uvfppirt	273	7	for	for	IN
cord-003091-uvfppirt	273	8	possible	possible	JJ
cord-003091-uvfppirt	273	9	therapeutic	therapeutic	JJ
cord-003091-uvfppirt	273	10	approaches	approach	NNS
cord-003091-uvfppirt	273	11	,	,	,
cord-003091-uvfppirt	273	12	theoretically	theoretically	RB
cord-003091-uvfppirt	273	13	applicable	applicable	JJ
cord-003091-uvfppirt	273	14	to	to	IN
cord-003091-uvfppirt	273	15	all	all	DT
cord-003091-uvfppirt	273	16	pathological	pathological	JJ
cord-003091-uvfppirt	273	17	contexts	context	NNS
cord-003091-uvfppirt	273	18	.	.	.
cord-003091-uvfppirt	274	1	Despite	despite	IN
cord-003091-uvfppirt	274	2	this	this	DT
cord-003091-uvfppirt	274	3	encouraging	encourage	VBG
cord-003091-uvfppirt	274	4	evidence	evidence	NN
cord-003091-uvfppirt	274	5	,	,	,
cord-003091-uvfppirt	274	6	several	several	JJ
cord-003091-uvfppirt	274	7	limitations	limitation	NNS
cord-003091-uvfppirt	274	8	or	or	CC
cord-003091-uvfppirt	274	9	issues	issue	NNS
cord-003091-uvfppirt	274	10	still	still	RB
cord-003091-uvfppirt	274	11	have	have	VBP
cord-003091-uvfppirt	274	12	to	to	TO
cord-003091-uvfppirt	274	13	be	be	VB
cord-003091-uvfppirt	274	14	overcome	overcome	VBN
cord-003091-uvfppirt	274	15	.	.	.
cord-003091-uvfppirt	275	1	Indeed	indeed	RB
cord-003091-uvfppirt	275	2	,	,	,
cord-003091-uvfppirt	275	3	more	more	JJR
cord-003091-uvfppirt	275	4	than	than	IN
cord-003091-uvfppirt	275	5	a	a	DT
cord-003091-uvfppirt	275	6	few	few	JJ
cord-003091-uvfppirt	275	7	vaccines	vaccine	NNS
cord-003091-uvfppirt	275	8	do	do	VBP
cord-003091-uvfppirt	275	9	not	not	RB
cord-003091-uvfppirt	275	10	pass	pass	VB
cord-003091-uvfppirt	275	11	phases	phase	NNS
cord-003091-uvfppirt	275	12	I	-PRON-	PRP
cord-003091-uvfppirt	275	13	of	of	IN
cord-003091-uvfppirt	275	14	clinical	clinical	JJ
cord-003091-uvfppirt	275	15	trials	trial	NNS
cord-003091-uvfppirt	275	16	either	either	CC
cord-003091-uvfppirt	275	17	for	for	IN
cord-003091-uvfppirt	275	18	toxicity	toxicity	NN
cord-003091-uvfppirt	275	19	issues	issue	NNS
cord-003091-uvfppirt	275	20	and	and	CC
cord-003091-uvfppirt	275	21	lack	lack	NN
cord-003091-uvfppirt	275	22	of	of	IN
cord-003091-uvfppirt	275	23	immunogenicity	immunogenicity	NN
cord-003091-uvfppirt	275	24	in	in	IN
cord-003091-uvfppirt	275	25	some	some	DT
cord-003091-uvfppirt	275	26	individuals	individual	NNS
cord-003091-uvfppirt	275	27	.	.	.
cord-003091-uvfppirt	276	1	What	what	WP
cord-003091-uvfppirt	276	2	is	be	VBZ
cord-003091-uvfppirt	276	3	missing	miss	VBG
cord-003091-uvfppirt	276	4	?	?	.
cord-003091-uvfppirt	277	1	Part	part	NN
cord-003091-uvfppirt	277	2	of	of	IN
cord-003091-uvfppirt	277	3	the	the	DT
cord-003091-uvfppirt	277	4	answer	answer	NN
cord-003091-uvfppirt	277	5	to	to	IN
cord-003091-uvfppirt	277	6	this	this	DT
cord-003091-uvfppirt	277	7	question	question	NN
cord-003091-uvfppirt	277	8	could	could	MD
cord-003091-uvfppirt	277	9	sit	sit	VB
cord-003091-uvfppirt	277	10	on	on	IN
cord-003091-uvfppirt	277	11	human	human	JJ
cord-003091-uvfppirt	277	12	genetics	genetic	NNS
cord-003091-uvfppirt	277	13	and	and	CC
cord-003091-uvfppirt	277	14	population	population	NN
cord-003091-uvfppirt	277	15	variability	variability	NN
cord-003091-uvfppirt	277	16	.	.	.
cord-003091-uvfppirt	278	1	Syngeneic	syngeneic	NN
cord-003091-uvfppirt	278	2	animal	animal	NN
cord-003091-uvfppirt	278	3	models	model	NNS
cord-003091-uvfppirt	278	4	are	be	VBP
cord-003091-uvfppirt	278	5	ideal	ideal	JJ
cord-003091-uvfppirt	278	6	settings	setting	NNS
cord-003091-uvfppirt	278	7	in	in	IN
cord-003091-uvfppirt	278	8	which	which	WDT
cord-003091-uvfppirt	278	9	the	the	DT
cord-003091-uvfppirt	278	10	systems	system	NNS
cord-003091-uvfppirt	278	11	are	be	VBP
cord-003091-uvfppirt	278	12	pushed	push	VBN
cord-003091-uvfppirt	278	13	although	although	IN
cord-003091-uvfppirt	278	14	they	-PRON-	PRP
cord-003091-uvfppirt	278	15	constitute	constitute	VBP
cord-003091-uvfppirt	278	16	a	a	DT
cord-003091-uvfppirt	278	17	necessary	necessary	JJ
cord-003091-uvfppirt	278	18	and	and	CC
cord-003091-uvfppirt	278	19	useful	useful	JJ
cord-003091-uvfppirt	278	20	step	step	NN
cord-003091-uvfppirt	278	21	preceding	precede	VBG
cord-003091-uvfppirt	278	22	clinical	clinical	JJ
cord-003091-uvfppirt	278	23	trials	trial	NNS
cord-003091-uvfppirt	278	24	.	.	.
cord-003091-uvfppirt	279	1	Moreover	moreover	RB
cord-003091-uvfppirt	279	2	,	,	,
cord-003091-uvfppirt	279	3	when	when	WRB
cord-003091-uvfppirt	279	4	translating	translate	VBG
cord-003091-uvfppirt	279	5	vaccine	vaccine	NN
cord-003091-uvfppirt	279	6	testing	testing	NN
cord-003091-uvfppirt	279	7	from	from	IN
cord-003091-uvfppirt	279	8	in	in	IN
cord-003091-uvfppirt	279	9	vivo	vivo	NN
cord-003091-uvfppirt	279	10	experiments	experiment	NNS
cord-003091-uvfppirt	279	11	on	on	IN
cord-003091-uvfppirt	279	12	animals	animal	NNS
cord-003091-uvfppirt	279	13	to	to	IN
cord-003091-uvfppirt	279	14	ex	ex	FW
cord-003091-uvfppirt	279	15	vivo	vivo	FW
cord-003091-uvfppirt	279	16	on	on	IN
cord-003091-uvfppirt	279	17	human	human	JJ
cord-003091-uvfppirt	279	18	cells	cell	NNS
cord-003091-uvfppirt	279	19	,	,	,
cord-003091-uvfppirt	279	20	often	often	RB
cord-003091-uvfppirt	279	21	the	the	DT
cord-003091-uvfppirt	279	22	opted	opt	VBN
cord-003091-uvfppirt	279	23	choice	choice	NN
cord-003091-uvfppirt	279	24	are	be	VBP
cord-003091-uvfppirt	279	25	blood	blood	NN
cord-003091-uvfppirt	279	26	human	human	JJ
cord-003091-uvfppirt	279	27	cells	cell	NNS
cord-003091-uvfppirt	279	28	,	,	,
cord-003091-uvfppirt	279	29	while	while	IN
cord-003091-uvfppirt	279	30	in	in	IN
cord-003091-uvfppirt	279	31	most	most	JJS
cord-003091-uvfppirt	279	32	of	of	IN
cord-003091-uvfppirt	279	33	the	the	DT
cord-003091-uvfppirt	279	34	cases	case	NNS
cord-003091-uvfppirt	279	35	vaccines	vaccine	NNS
cord-003091-uvfppirt	279	36	will	will	MD
cord-003091-uvfppirt	279	37	be	be	VB
cord-003091-uvfppirt	279	38	administered	administer	VBN
cord-003091-uvfppirt	279	39	in	in	IN
cord-003091-uvfppirt	279	40	the	the	DT
cord-003091-uvfppirt	279	41	skin	skin	NN
cord-003091-uvfppirt	279	42	,	,	,
cord-003091-uvfppirt	279	43	having	have	VBG
cord-003091-uvfppirt	279	44	a	a	DT
cord-003091-uvfppirt	279	45	complete	complete	JJ
cord-003091-uvfppirt	279	46	different	different	JJ
cord-003091-uvfppirt	279	47	DCs	dc	NNS
cord-003091-uvfppirt	279	48	-	-	HYPH
cord-003091-uvfppirt	279	49	based	base	VBN
cord-003091-uvfppirt	279	50	milieu	milieu	NN
cord-003091-uvfppirt	279	51	(	(	-LRB-
cord-003091-uvfppirt	279	52	15	15	CD
cord-003091-uvfppirt	279	53	)	)	-RRB-
cord-003091-uvfppirt	279	54	.	.	.
cord-003091-uvfppirt	280	1	Crucially	crucially	RB
cord-003091-uvfppirt	280	2	,	,	,
cord-003091-uvfppirt	280	3	Idoyaga	Idoyaga	NNP
cord-003091-uvfppirt	280	4	and	and	CC
cord-003091-uvfppirt	280	5	colleagues	colleague	NNS
cord-003091-uvfppirt	280	6	dissected	dissect	VBD
cord-003091-uvfppirt	280	7	the	the	DT
cord-003091-uvfppirt	280	8	interindividual	interindividual	JJ
cord-003091-uvfppirt	280	9	variability	variability	NN
cord-003091-uvfppirt	280	10	in	in	IN
cord-003091-uvfppirt	280	11	skin	skin	NN
cord-003091-uvfppirt	280	12	-	-	HYPH
cord-003091-uvfppirt	280	13	resident	resident	NN
cord-003091-uvfppirt	280	14	DCs	dc	NNS
cord-003091-uvfppirt	280	15	,	,	,
cord-003091-uvfppirt	280	16	stressing	stress	VBG
cord-003091-uvfppirt	280	17	the	the	DT
cord-003091-uvfppirt	280	18	need	need	NN
cord-003091-uvfppirt	280	19	of	of	IN
cord-003091-uvfppirt	280	20	shedding	shed	VBG
cord-003091-uvfppirt	280	21	light	light	NN
cord-003091-uvfppirt	280	22	on	on	IN
cord-003091-uvfppirt	280	23	the	the	DT
cord-003091-uvfppirt	280	24	effects	effect	NNS
cord-003091-uvfppirt	280	25	that	that	WDT
cord-003091-uvfppirt	280	26	genetics	genetic	NNS
cord-003091-uvfppirt	280	27	and	and	CC
cord-003091-uvfppirt	280	28	environment	environment	NN
cord-003091-uvfppirt	280	29	imprint	imprint	NN
cord-003091-uvfppirt	280	30	on	on	IN
cord-003091-uvfppirt	280	31	DCs	DCs	NNP
cord-003091-uvfppirt	280	32	.	.	.
cord-003091-uvfppirt	281	1	It	-PRON-	PRP
cord-003091-uvfppirt	281	2	is	be	VBZ
cord-003091-uvfppirt	281	3	compulsory	compulsory	JJ
cord-003091-uvfppirt	281	4	to	to	TO
cord-003091-uvfppirt	281	5	decode	decode	VB
cord-003091-uvfppirt	281	6	the	the	DT
cord-003091-uvfppirt	281	7	complex	complex	JJ
cord-003091-uvfppirt	281	8	scenario	scenario	NN
cord-003091-uvfppirt	281	9	of	of	IN
cord-003091-uvfppirt	281	10	human	human	JJ
cord-003091-uvfppirt	281	11	diversity	diversity	NN
cord-003091-uvfppirt	281	12	to	to	TO
cord-003091-uvfppirt	281	13	provide	provide	VB
cord-003091-uvfppirt	281	14	personalized	personalized	JJ
cord-003091-uvfppirt	281	15	therapies	therapy	NNS
cord-003091-uvfppirt	281	16	with	with	IN
cord-003091-uvfppirt	281	17	increased	increase	VBN
cord-003091-uvfppirt	281	18	efficacy	efficacy	NN
cord-003091-uvfppirt	281	19	.	.	.
cord-003091-uvfppirt	282	1	In	in	IN
cord-003091-uvfppirt	282	2	the	the	DT
cord-003091-uvfppirt	282	3	Omics	Omics	NNP
cord-003091-uvfppirt	282	4	era	era	NN
cord-003091-uvfppirt	282	5	,	,	,
cord-003091-uvfppirt	282	6	systems	system	NNS
cord-003091-uvfppirt	282	7	biology	biology	NN
cord-003091-uvfppirt	282	8	and	and	CC
cord-003091-uvfppirt	282	9	computational	computational	JJ
cord-003091-uvfppirt	282	10	modeling	modeling	NN
cord-003091-uvfppirt	282	11	integrate	integrate	VBP
cord-003091-uvfppirt	282	12	huge	huge	JJ
cord-003091-uvfppirt	282	13	data	datum	NNS
cord-003091-uvfppirt	282	14	-	-	HYPH
cord-003091-uvfppirt	282	15	sets	set	NNS
cord-003091-uvfppirt	282	16	to	to	TO
cord-003091-uvfppirt	282	17	address	address	VB
cord-003091-uvfppirt	282	18	the	the	DT
cord-003091-uvfppirt	282	19	urgent	urgent	JJ
cord-003091-uvfppirt	282	20	need	need	NN
cord-003091-uvfppirt	282	21	of	of	IN
cord-003091-uvfppirt	282	22	information	information	NN
cord-003091-uvfppirt	282	23	on	on	IN
cord-003091-uvfppirt	282	24	the	the	DT
cord-003091-uvfppirt	282	25	global	global	JJ
cord-003091-uvfppirt	282	26	behavior	behavior	NN
cord-003091-uvfppirt	282	27	.	.	.
cord-003091-uvfppirt	283	1	Indeed	indeed	RB
cord-003091-uvfppirt	283	2	,	,	,
cord-003091-uvfppirt	283	3	Genome	Genome	NNP
cord-003091-uvfppirt	283	4	-	-	HYPH
cord-003091-uvfppirt	283	5	wide	wide	JJ
cord-003091-uvfppirt	283	6	association	association	NN
cord-003091-uvfppirt	283	7	studies	study	NNS
cord-003091-uvfppirt	283	8	have	have	VBP
cord-003091-uvfppirt	283	9	provided	provide	VBN
cord-003091-uvfppirt	283	10	insights	insight	NNS
cord-003091-uvfppirt	283	11	into	into	IN
cord-003091-uvfppirt	283	12	human	human	JJ
cord-003091-uvfppirt	283	13	genetics	genetics	NN
cord-003091-uvfppirt	283	14	variants	variant	NNS
cord-003091-uvfppirt	283	15	associated	associate	VBN
cord-003091-uvfppirt	283	16	to	to	IN
cord-003091-uvfppirt	283	17	the	the	DT
cord-003091-uvfppirt	283	18	immunogenicity	immunogenicity	NN
cord-003091-uvfppirt	283	19	of	of	IN
cord-003091-uvfppirt	283	20	vaccines	vaccine	NNS
cord-003091-uvfppirt	283	21	(	(	-LRB-
cord-003091-uvfppirt	283	22	179	179	CD
cord-003091-uvfppirt	283	23	,	,	,
cord-003091-uvfppirt	283	24	180	180	CD
cord-003091-uvfppirt	283	25	)	)	-RRB-
cord-003091-uvfppirt	283	26	.	.	.
cord-003091-uvfppirt	284	1	Therefore	therefore	RB
cord-003091-uvfppirt	284	2	,	,	,
cord-003091-uvfppirt	284	3	integration	integration	NN
cord-003091-uvfppirt	284	4	of	of	IN
cord-003091-uvfppirt	284	5	"	"	``
cord-003091-uvfppirt	284	6	wet	wet	JJ
cord-003091-uvfppirt	284	7	"	"	''
cord-003091-uvfppirt	284	8	evidence	evidence	NN
cord-003091-uvfppirt	284	9	and	and	CC
cord-003091-uvfppirt	284	10	"	"	``
cord-003091-uvfppirt	284	11	dry	dry	JJ
cord-003091-uvfppirt	284	12	"	"	''
cord-003091-uvfppirt	284	13	notions	notion	NNS
cord-003091-uvfppirt	284	14	may	may	MD
cord-003091-uvfppirt	284	15	fasten	fasten	VB
cord-003091-uvfppirt	284	16	the	the	DT
cord-003091-uvfppirt	284	17	designing	designing	NN
cord-003091-uvfppirt	284	18	process	process	NN
cord-003091-uvfppirt	284	19	and	and	CC
cord-003091-uvfppirt	284	20	provide	provide	VB
cord-003091-uvfppirt	284	21	both	both	DT
cord-003091-uvfppirt	284	22	efficient	efficient	JJ
cord-003091-uvfppirt	284	23	vaccine	vaccine	NN
cord-003091-uvfppirt	284	24	strategies	strategy	NNS
cord-003091-uvfppirt	284	25	and	and	CC
cord-003091-uvfppirt	284	26	their	-PRON-	PRP$
cord-003091-uvfppirt	284	27	predictive	predictive	JJ
cord-003091-uvfppirt	284	28	efficacy	efficacy	NN
cord-003091-uvfppirt	284	29	.	.	.
cord-003091-uvfppirt	285	1	All	all	DT
cord-003091-uvfppirt	285	2	authors	author	NNS
cord-003091-uvfppirt	285	3	listed	list	VBN
cord-003091-uvfppirt	285	4	have	have	VBP
cord-003091-uvfppirt	285	5	made	make	VBN
cord-003091-uvfppirt	285	6	a	a	DT
cord-003091-uvfppirt	285	7	substantial	substantial	JJ
cord-003091-uvfppirt	285	8	,	,	,
cord-003091-uvfppirt	285	9	direct	direct	JJ
cord-003091-uvfppirt	285	10	,	,	,
cord-003091-uvfppirt	285	11	and	and	CC
cord-003091-uvfppirt	285	12	intellectual	intellectual	JJ
cord-003091-uvfppirt	285	13	contribution	contribution	NN
cord-003091-uvfppirt	285	14	to	to	IN
cord-003091-uvfppirt	285	15	the	the	DT
cord-003091-uvfppirt	285	16	work	work	NN
cord-003091-uvfppirt	285	17	and	and	CC
cord-003091-uvfppirt	285	18	approved	approve	VBD
cord-003091-uvfppirt	285	19	it	-PRON-	PRP
cord-003091-uvfppirt	285	20	for	for	IN
cord-003091-uvfppirt	285	21	publication	publication	NN
cord-003091-uvfppirt	285	22	.	.	.
cord-003091-uvfppirt	285	23	 	 	_SP
cord-003091-uvfppirt	286	1	Eradicating	eradicate	VBG
cord-003091-uvfppirt	286	2	infectious	infectious	JJ
cord-003091-uvfppirt	286	3	disease	disease	NN
cord-003091-uvfppirt	286	4	:	:	:
cord-003091-uvfppirt	286	5	can	can	MD
cord-003091-uvfppirt	286	6	we	-PRON-	PRP
cord-003091-uvfppirt	286	7	and	and	CC
cord-003091-uvfppirt	286	8	should	should	MD
cord-003091-uvfppirt	286	9	we	-PRON-	PRP
cord-003091-uvfppirt	286	10	?	?	.
cord-003091-uvfppirt	287	1	Front	Front	NNP
cord-003091-uvfppirt	287	2	Immunol	Immunol	NNP
cord-003091-uvfppirt	287	3	Anti	Anti	NNP
cord-003091-uvfppirt	287	4	-	-	NNP
cord-003091-uvfppirt	287	5	immunology	immunology	NN
cord-003091-uvfppirt	287	6	:	:	:
cord-003091-uvfppirt	287	7	evasion	evasion	NN
cord-003091-uvfppirt	287	8	of	of	IN
cord-003091-uvfppirt	287	9	the	the	DT
cord-003091-uvfppirt	287	10	host	host	NN
cord-003091-uvfppirt	287	11	immune	immune	JJ
cord-003091-uvfppirt	287	12	system	system	NN
cord-003091-uvfppirt	287	13	by	by	IN
cord-003091-uvfppirt	287	14	bacterial	bacterial	JJ
cord-003091-uvfppirt	287	15	and	and	CC
cord-003091-uvfppirt	287	16	viral	viral	JJ
cord-003091-uvfppirt	287	17	pathogens	pathogen	NNS
cord-003091-uvfppirt	288	1	Why	why	WRB
cord-003091-uvfppirt	288	2	do	do	VBP
cord-003091-uvfppirt	288	3	n't	not	RB
cord-003091-uvfppirt	288	4	we	-PRON-	PRP
cord-003091-uvfppirt	288	5	have	have	VB
cord-003091-uvfppirt	288	6	an	an	DT
cord-003091-uvfppirt	288	7	effective	effective	JJ
cord-003091-uvfppirt	288	8	tuberculosis	tuberculosis	NN
cord-003091-uvfppirt	288	9	vaccine	vaccine	NN
cord-003091-uvfppirt	288	10	yet	yet	RB
cord-003091-uvfppirt	288	11	?	?	.
cord-003091-uvfppirt	289	1	Conserved	conserved	JJ
cord-003091-uvfppirt	289	2	HIV	HIV	NNP
cord-003091-uvfppirt	289	3	epitopes	epitope	NNS
cord-003091-uvfppirt	289	4	for	for	IN
cord-003091-uvfppirt	289	5	an	an	DT
cord-003091-uvfppirt	289	6	effective	effective	JJ
cord-003091-uvfppirt	289	7	HIV	HIV	NNP
cord-003091-uvfppirt	289	8	vaccine	vaccine	NN
cord-003091-uvfppirt	289	9	Hallmarks	Hallmarks	NNP
cord-003091-uvfppirt	289	10	of	of	IN
cord-003091-uvfppirt	289	11	cancer	cancer	NN
cord-003091-uvfppirt	289	12	:	:	:
cord-003091-uvfppirt	289	13	the	the	DT
cord-003091-uvfppirt	289	14	next	next	JJ
cord-003091-uvfppirt	289	15	generation	generation	NN
cord-003091-uvfppirt	289	16	Dendritic	dendritic	JJ
cord-003091-uvfppirt	289	17	cells	cell	NNS
cord-003091-uvfppirt	289	18	and	and	CC
cord-003091-uvfppirt	289	19	the	the	DT
cord-003091-uvfppirt	289	20	control	control	NN
cord-003091-uvfppirt	289	21	of	of	IN
cord-003091-uvfppirt	289	22	immunity	immunity	NN
cord-003091-uvfppirt	289	23	Identification	identification	NN
cord-003091-uvfppirt	289	24	of	of	IN
cord-003091-uvfppirt	289	25	a	a	DT
cord-003091-uvfppirt	289	26	novel	novel	JJ
cord-003091-uvfppirt	289	27	cell	cell	NN
cord-003091-uvfppirt	289	28	type	type	NN
cord-003091-uvfppirt	289	29	in	in	IN
cord-003091-uvfppirt	289	30	peripheral	peripheral	JJ
cord-003091-uvfppirt	289	31	lymphoid	lymphoid	JJ
cord-003091-uvfppirt	289	32	organs	organ	NNS
cord-003091-uvfppirt	289	33	of	of	IN
cord-003091-uvfppirt	289	34	mice	mouse	NNS
cord-003091-uvfppirt	289	35	.	.	.
cord-003091-uvfppirt	290	1	I.	I.	NNP
cord-003091-uvfppirt	290	2	Morphology	morphology	NN
cord-003091-uvfppirt	290	3	,	,	,
cord-003091-uvfppirt	290	4	quantitation	quantitation	NN
cord-003091-uvfppirt	290	5	,	,	,
cord-003091-uvfppirt	290	6	tissue	tissue	NN
cord-003091-uvfppirt	290	7	distribution	distribution	NN
cord-003091-uvfppirt	290	8	Identification	identification	NN
cord-003091-uvfppirt	290	9	of	of	IN
cord-003091-uvfppirt	290	10	a	a	DT
cord-003091-uvfppirt	290	11	novel	novel	JJ
cord-003091-uvfppirt	290	12	cell	cell	NN
cord-003091-uvfppirt	290	13	type	type	NN
cord-003091-uvfppirt	290	14	in	in	IN
cord-003091-uvfppirt	290	15	peripheral	peripheral	JJ
cord-003091-uvfppirt	290	16	lympoid	lympoid	JJ
cord-003091-uvfppirt	290	17	organs	organ	NNS
cord-003091-uvfppirt	290	18	of	of	IN
cord-003091-uvfppirt	290	19	mice	mouse	NNS
cord-003091-uvfppirt	290	20	.	.	.
cord-003091-uvfppirt	291	1	II	II	NNP
cord-003091-uvfppirt	291	2	.	.	.
cord-003091-uvfppirt	292	1	Functional	functional	JJ
cord-003091-uvfppirt	292	2	properties	property	NNS
cord-003091-uvfppirt	292	3	in	in	IN
cord-003091-uvfppirt	292	4	vitro	vitro	FW
cord-003091-uvfppirt	292	5	Dendritic	dendritic	JJ
cord-003091-uvfppirt	292	6	cells	cell	NNS
cord-003091-uvfppirt	292	7	display	display	VBP
cord-003091-uvfppirt	292	8	subset	subset	JJ
cord-003091-uvfppirt	292	9	and	and	CC
cord-003091-uvfppirt	292	10	tissue	tissue	NN
cord-003091-uvfppirt	292	11	-	-	HYPH
cord-003091-uvfppirt	292	12	specific	specific	JJ
cord-003091-uvfppirt	292	13	maturation	maturation	NN
cord-003091-uvfppirt	292	14	dynamics	dynamic	NNS
cord-003091-uvfppirt	292	15	over	over	IN
cord-003091-uvfppirt	292	16	human	human	JJ
cord-003091-uvfppirt	292	17	life	life	NN
cord-003091-uvfppirt	292	18	Unsupervised	unsupervised	JJ
cord-003091-uvfppirt	292	19	high	high	JJ
cord-003091-uvfppirt	292	20	-	-	HYPH
cord-003091-uvfppirt	292	21	dimensional	dimensional	JJ
cord-003091-uvfppirt	292	22	analysis	analysis	NN
cord-003091-uvfppirt	292	23	aligns	align	VBZ
cord-003091-uvfppirt	292	24	dendritic	dendritic	JJ
cord-003091-uvfppirt	292	25	cells	cell	NNS
cord-003091-uvfppirt	292	26	across	across	IN
cord-003091-uvfppirt	292	27	tissues	tissue	NNS
cord-003091-uvfppirt	292	28	and	and	CC
cord-003091-uvfppirt	292	29	species	specie	NNS
cord-003091-uvfppirt	293	1	Lymphoid	lymphoid	JJ
cord-003091-uvfppirt	293	2	organ	organ	NN
cord-003091-uvfppirt	293	3	-	-	HYPH
cord-003091-uvfppirt	293	4	resident	resident	NN
cord-003091-uvfppirt	293	5	dendritic	dendritic	JJ
cord-003091-uvfppirt	293	6	cells	cell	NNS
cord-003091-uvfppirt	293	7	exhibit	exhibit	VBP
cord-003091-uvfppirt	293	8	unique	unique	JJ
cord-003091-uvfppirt	293	9	transcriptional	transcriptional	JJ
cord-003091-uvfppirt	293	10	fingerprints	fingerprint	NNS
cord-003091-uvfppirt	293	11	based	base	VBN
cord-003091-uvfppirt	293	12	on	on	IN
cord-003091-uvfppirt	293	13	subset	subset	JJ
cord-003091-uvfppirt	293	14	and	and	CC
cord-003091-uvfppirt	293	15	site	site	JJ
cord-003091-uvfppirt	293	16	Single	single	JJ
cord-003091-uvfppirt	293	17	-	-	HYPH
cord-003091-uvfppirt	293	18	cell	cell	NN
cord-003091-uvfppirt	293	19	RNA	RNA	NNP
cord-003091-uvfppirt	293	20	-	-	HYPH
cord-003091-uvfppirt	293	21	seq	seq	NNP
cord-003091-uvfppirt	294	1	reveals	reveal	VBZ
cord-003091-uvfppirt	294	2	new	new	JJ
cord-003091-uvfppirt	294	3	types	type	NNS
cord-003091-uvfppirt	294	4	of	of	IN
cord-003091-uvfppirt	294	5	human	human	JJ
cord-003091-uvfppirt	294	6	blood	blood	NN
cord-003091-uvfppirt	294	7	dendritic	dendritic	JJ
cord-003091-uvfppirt	294	8	cells	cell	NNS
cord-003091-uvfppirt	294	9	,	,	,
cord-003091-uvfppirt	294	10	monocytes	monocyte	NNS
cord-003091-uvfppirt	294	11	,	,	,
cord-003091-uvfppirt	294	12	and	and	CC
cord-003091-uvfppirt	294	13	progenitors	progenitor	NNS
cord-003091-uvfppirt	294	14	Human	human	JJ
cord-003091-uvfppirt	294	15	lymphoid	lymphoid	JJ
cord-003091-uvfppirt	294	16	organ	organ	NN
cord-003091-uvfppirt	294	17	dendritic	dendritic	JJ
cord-003091-uvfppirt	294	18	cell	cell	NN
cord-003091-uvfppirt	294	19	identity	identity	NN
cord-003091-uvfppirt	294	20	is	be	VBZ
cord-003091-uvfppirt	294	21	predominantly	predominantly	RB
cord-003091-uvfppirt	294	22	dictated	dictate	VBN
cord-003091-uvfppirt	294	23	by	by	IN
cord-003091-uvfppirt	294	24	ontogeny	ontogeny	NN
cord-003091-uvfppirt	294	25	,	,	,
cord-003091-uvfppirt	294	26	not	not	RB
cord-003091-uvfppirt	294	27	tissue	tissue	NN
cord-003091-uvfppirt	294	28	microenvironment	microenvironment	NN
cord-003091-uvfppirt	295	1	The	the	DT
cord-003091-uvfppirt	295	2	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	3	cell	cell	NN
cord-003091-uvfppirt	295	4	lineage	lineage	NN
cord-003091-uvfppirt	295	5	:	:	:
cord-003091-uvfppirt	295	6	ontogeny	ontogeny	NN
cord-003091-uvfppirt	295	7	and	and	CC
cord-003091-uvfppirt	295	8	function	function	NN
cord-003091-uvfppirt	295	9	of	of	IN
cord-003091-uvfppirt	295	10	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	11	cells	cell	NNS
cord-003091-uvfppirt	295	12	and	and	CC
cord-003091-uvfppirt	295	13	their	-PRON-	PRP$
cord-003091-uvfppirt	295	14	subsets	subset	NNS
cord-003091-uvfppirt	295	15	in	in	IN
cord-003091-uvfppirt	295	16	the	the	DT
cord-003091-uvfppirt	295	17	steady	steady	JJ
cord-003091-uvfppirt	295	18	state	state	NN
cord-003091-uvfppirt	295	19	and	and	CC
cord-003091-uvfppirt	295	20	the	the	DT
cord-003091-uvfppirt	295	21	inflamed	inflamed	JJ
cord-003091-uvfppirt	295	22	setting	set	VBG
cord-003091-uvfppirt	295	23	High	high	JJ
cord-003091-uvfppirt	295	24	-	-	HYPH
cord-003091-uvfppirt	295	25	dimensional	dimensional	JJ
cord-003091-uvfppirt	295	26	phenotypic	phenotypic	JJ
cord-003091-uvfppirt	295	27	mapping	mapping	NN
cord-003091-uvfppirt	295	28	of	of	IN
cord-003091-uvfppirt	295	29	human	human	JJ
cord-003091-uvfppirt	295	30	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	31	cells	cell	NNS
cord-003091-uvfppirt	295	32	reveals	reveal	VBZ
cord-003091-uvfppirt	295	33	interindividual	interindividual	JJ
cord-003091-uvfppirt	295	34	variation	variation	NN
cord-003091-uvfppirt	295	35	and	and	CC
cord-003091-uvfppirt	295	36	tissue	tissue	NN
cord-003091-uvfppirt	295	37	specialization	specialization	NN
cord-003091-uvfppirt	295	38	Mapping	map	VBG
cord-003091-uvfppirt	295	39	the	the	DT
cord-003091-uvfppirt	295	40	human	human	JJ
cord-003091-uvfppirt	295	41	DC	DC	NNP
cord-003091-uvfppirt	295	42	lineage	lineage	NN
cord-003091-uvfppirt	295	43	through	through	IN
cord-003091-uvfppirt	295	44	the	the	DT
cord-003091-uvfppirt	295	45	integration	integration	NN
cord-003091-uvfppirt	295	46	of	of	IN
cord-003091-uvfppirt	295	47	high	high	JJ
cord-003091-uvfppirt	295	48	-	-	HYPH
cord-003091-uvfppirt	295	49	dimensional	dimensional	JJ
cord-003091-uvfppirt	295	50	techniques	technique	NNS
cord-003091-uvfppirt	295	51	Development	development	NN
cord-003091-uvfppirt	295	52	and	and	CC
cord-003091-uvfppirt	295	53	function	function	NN
cord-003091-uvfppirt	295	54	of	of	IN
cord-003091-uvfppirt	295	55	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	56	cell	cell	NN
cord-003091-uvfppirt	295	57	subsets	subset	NNS
cord-003091-uvfppirt	295	58	Characterization	characterization	NN
cord-003091-uvfppirt	295	59	of	of	IN
cord-003091-uvfppirt	295	60	resident	resident	JJ
cord-003091-uvfppirt	295	61	and	and	CC
cord-003091-uvfppirt	295	62	migratory	migratory	JJ
cord-003091-uvfppirt	295	63	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	64	cells	cell	NNS
cord-003091-uvfppirt	295	65	in	in	IN
cord-003091-uvfppirt	295	66	human	human	JJ
cord-003091-uvfppirt	295	67	lymph	lymph	NN
cord-003091-uvfppirt	295	68	nodes	node	NNS
cord-003091-uvfppirt	295	69	Candida	Candida	NNP
cord-003091-uvfppirt	295	70	albicans	albican	NNS
cord-003091-uvfppirt	295	71	morphology	morphology	NN
cord-003091-uvfppirt	295	72	and	and	CC
cord-003091-uvfppirt	295	73	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	74	cell	cell	NN
cord-003091-uvfppirt	295	75	subsets	subset	NNS
cord-003091-uvfppirt	295	76	determine	determine	VBP
cord-003091-uvfppirt	295	77	T	T	NNP
cord-003091-uvfppirt	295	78	helper	helper	NN
cord-003091-uvfppirt	295	79	cell	cell	NN
cord-003091-uvfppirt	295	80	differentiation	differentiation	NN
cord-003091-uvfppirt	295	81	Skin	skin	NN
cord-003091-uvfppirt	295	82	-	-	HYPH
cord-003091-uvfppirt	295	83	resident	resident	NN
cord-003091-uvfppirt	295	84	murine	murine	JJ
cord-003091-uvfppirt	295	85	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	86	cell	cell	NN
cord-003091-uvfppirt	295	87	subsets	subset	NNS
cord-003091-uvfppirt	295	88	promote	promote	VBP
cord-003091-uvfppirt	295	89	distinct	distinct	JJ
cord-003091-uvfppirt	295	90	and	and	CC
cord-003091-uvfppirt	295	91	opposing	oppose	VBG
cord-003091-uvfppirt	295	92	antigen	antigen	NN
cord-003091-uvfppirt	295	93	-	-	HYPH
cord-003091-uvfppirt	295	94	specific	specific	JJ
cord-003091-uvfppirt	295	95	T	T	NNP
cord-003091-uvfppirt	295	96	helper	helper	NN
cord-003091-uvfppirt	295	97	cell	cell	NN
cord-003091-uvfppirt	295	98	responses	response	NNS
cord-003091-uvfppirt	295	99	Pattern	Pattern	NNP
cord-003091-uvfppirt	295	100	recognition	recognition	NN
cord-003091-uvfppirt	295	101	receptors	receptor	NNS
cord-003091-uvfppirt	295	102	and	and	CC
cord-003091-uvfppirt	295	103	inflammation	inflammation	NN
cord-003091-uvfppirt	295	104	CCR7	CCR7	NNP
cord-003091-uvfppirt	295	105	and	and	CC
cord-003091-uvfppirt	295	106	IRF4-dependent	IRF4-dependent	NNP
cord-003091-uvfppirt	295	107	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	108	cells	cell	NNS
cord-003091-uvfppirt	295	109	regulate	regulate	VBP
cord-003091-uvfppirt	295	110	lymphatic	lymphatic	NN
cord-003091-uvfppirt	295	111	collecting	collecting	NN
cord-003091-uvfppirt	295	112	vessel	vessel	NN
cord-003091-uvfppirt	295	113	permeability	permeability	NN
cord-003091-uvfppirt	295	114	Lymph	lymph	NN
cord-003091-uvfppirt	295	115	node	node	NN
cord-003091-uvfppirt	295	116	homing	homing	NN
cord-003091-uvfppirt	295	117	of	of	IN
cord-003091-uvfppirt	295	118	T	t	NN
cord-003091-uvfppirt	295	119	cells	cell	NNS
cord-003091-uvfppirt	295	120	and	and	CC
cord-003091-uvfppirt	295	121	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	122	cells	cell	NNS
cord-003091-uvfppirt	295	123	via	via	IN
cord-003091-uvfppirt	295	124	afferent	afferent	JJ
cord-003091-uvfppirt	295	125	lymphatics	lymphatic	NNS
cord-003091-uvfppirt	295	126	Afferent	Afferent	NNP
cord-003091-uvfppirt	295	127	lymph	lymph	NN
cord-003091-uvfppirt	295	128	-	-	HYPH
cord-003091-uvfppirt	295	129	derived	derive	VBN
cord-003091-uvfppirt	295	130	T	t	NN
cord-003091-uvfppirt	295	131	cells	cell	NNS
cord-003091-uvfppirt	295	132	and	and	CC
cord-003091-uvfppirt	295	133	DCs	dc	NNS
cord-003091-uvfppirt	295	134	use	use	VBP
cord-003091-uvfppirt	295	135	different	different	JJ
cord-003091-uvfppirt	295	136	chemokine	chemokine	NN
cord-003091-uvfppirt	295	137	receptor	receptor	NN
cord-003091-uvfppirt	295	138	CCR7-dependent	CCR7-dependent	NNP
cord-003091-uvfppirt	295	139	routes	route	NNS
cord-003091-uvfppirt	295	140	for	for	IN
cord-003091-uvfppirt	295	141	entry	entry	NN
cord-003091-uvfppirt	295	142	into	into	IN
cord-003091-uvfppirt	295	143	the	the	DT
cord-003091-uvfppirt	295	144	lymph	lymph	NN
cord-003091-uvfppirt	295	145	node	node	NN
cord-003091-uvfppirt	295	146	and	and	CC
cord-003091-uvfppirt	295	147	intranodal	intranodal	JJ
cord-003091-uvfppirt	295	148	migration	migration	NN
cord-003091-uvfppirt	295	149	Distinct	distinct	JJ
cord-003091-uvfppirt	295	150	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	151	cell	cell	NN
cord-003091-uvfppirt	295	152	populations	population	NNS
cord-003091-uvfppirt	295	153	sequentially	sequentially	RB
cord-003091-uvfppirt	295	154	present	present	VBP
cord-003091-uvfppirt	295	155	antigen	antigen	NN
cord-003091-uvfppirt	295	156	to	to	IN
cord-003091-uvfppirt	295	157	CD4	CD4	NNP
cord-003091-uvfppirt	295	158	T	T	NNP
cord-003091-uvfppirt	295	159	cells	cell	NNS
cord-003091-uvfppirt	295	160	and	and	CC
cord-003091-uvfppirt	295	161	stimulate	stimulate	VB
cord-003091-uvfppirt	295	162	different	different	JJ
cord-003091-uvfppirt	295	163	aspects	aspect	NNS
cord-003091-uvfppirt	295	164	of	of	IN
cord-003091-uvfppirt	295	165	cell	cell	NN
cord-003091-uvfppirt	295	166	-	-	HYPH
cord-003091-uvfppirt	295	167	mediated	mediate	VBN
cord-003091-uvfppirt	295	168	immunity	immunity	NN
cord-003091-uvfppirt	295	169	Migratory	Migratory	NNP
cord-003091-uvfppirt	295	170	,	,	,
cord-003091-uvfppirt	295	171	and	and	CC
cord-003091-uvfppirt	295	172	not	not	RB
cord-003091-uvfppirt	295	173	lymphoid	lymphoid	NN
cord-003091-uvfppirt	295	174	-	-	HYPH
cord-003091-uvfppirt	295	175	resident	resident	JJ
cord-003091-uvfppirt	295	176	,	,	,
cord-003091-uvfppirt	295	177	dendritic	dendritic	JJ
cord-003091-uvfppirt	295	178	cells	cell	NNS
cord-003091-uvfppirt	295	179	maintain	maintain	VBP
cord-003091-uvfppirt	295	180	peripheral	peripheral	JJ
cord-003091-uvfppirt	295	181	self	self	NN
cord-003091-uvfppirt	295	182	-	-	HYPH
cord-003091-uvfppirt	295	183	tolerance	tolerance	NN
cord-003091-uvfppirt	295	184	and	and	CC
cord-003091-uvfppirt	295	185	prevent	prevent	VB
cord-003091-uvfppirt	295	186	autoimmunity	autoimmunity	NN
cord-003091-uvfppirt	295	187	via	via	IN
cord-003091-uvfppirt	295	188	induction	induction	NN
cord-003091-uvfppirt	295	189	of	of	IN
cord-003091-uvfppirt	295	190	iTreg	iTreg	NNP
cord-003091-uvfppirt	295	191	cells	cell	NNS
cord-003091-uvfppirt	295	192	Dendritic	dendritic	JJ
cord-003091-uvfppirt	295	193	cells	cell	NNS
cord-003091-uvfppirt	295	194	induce	induce	VBP
cord-003091-uvfppirt	295	195	peripheral	peripheral	JJ
cord-003091-uvfppirt	295	196	T	t	NN
cord-003091-uvfppirt	295	197	cell	cell	NN
cord-003091-uvfppirt	295	198	unresponsiveness	unresponsiveness	NN
cord-003091-uvfppirt	295	199	under	under	IN
cord-003091-uvfppirt	295	200	steady	steady	JJ
cord-003091-uvfppirt	295	201	state	state	NN
cord-003091-uvfppirt	295	202	conditions	condition	NNS
cord-003091-uvfppirt	295	203	in	in	IN
cord-003091-uvfppirt	295	204	vivo	vivo	NNP
cord-003091-uvfppirt	295	205	Tolerogenic	Tolerogenic	NNP
cord-003091-uvfppirt	295	206	dendritic	dendritic	NN
cord-003091-uvfppirt	295	207	cells	cell	NNS
cord-003091-uvfppirt	295	208	Th17	Th17	.
cord-003091-uvfppirt	296	1	cells	cell	NNS
cord-003091-uvfppirt	296	2	in	in	IN
cord-003091-uvfppirt	296	3	mucosal	mucosal	JJ
cord-003091-uvfppirt	296	4	immunity	immunity	NN
cord-003091-uvfppirt	296	5	and	and	CC
cord-003091-uvfppirt	296	6	tissue	tissue	NN
cord-003091-uvfppirt	296	7	inflammation	inflammation	NN
cord-003091-uvfppirt	296	8	CD14	CD14	NNP
cord-003091-uvfppirt	296	9	regulates	regulate	VBZ
cord-003091-uvfppirt	296	10	the	the	DT
cord-003091-uvfppirt	296	11	dendritic	dendritic	JJ
cord-003091-uvfppirt	296	12	cell	cell	NN
cord-003091-uvfppirt	296	13	life	life	NN
cord-003091-uvfppirt	296	14	cycle	cycle	NN
cord-003091-uvfppirt	296	15	after	after	IN
cord-003091-uvfppirt	296	16	LPS	LPS	NNP
cord-003091-uvfppirt	296	17	exposure	exposure	NN
cord-003091-uvfppirt	296	18	through	through	IN
cord-003091-uvfppirt	296	19	NFAT	NFAT	NNP
cord-003091-uvfppirt	296	20	activation	activation	NN
cord-003091-uvfppirt	296	21	Dendritic	dendritic	JJ
cord-003091-uvfppirt	296	22	cell	cell	NN
cord-003091-uvfppirt	296	23	apoptosis	apoptosis	NN
cord-003091-uvfppirt	296	24	in	in	IN
cord-003091-uvfppirt	296	25	the	the	DT
cord-003091-uvfppirt	296	26	maintenance	maintenance	NN
cord-003091-uvfppirt	296	27	of	of	IN
cord-003091-uvfppirt	296	28	immune	immune	JJ
cord-003091-uvfppirt	296	29	tolerance	tolerance	NN
cord-003091-uvfppirt	296	30	Elimination	elimination	NN
cord-003091-uvfppirt	296	31	of	of	IN
cord-003091-uvfppirt	296	32	antigen	antigen	NN
cord-003091-uvfppirt	296	33	-	-	HYPH
cord-003091-uvfppirt	296	34	presenting	present	VBG
cord-003091-uvfppirt	296	35	cells	cell	NNS
cord-003091-uvfppirt	296	36	and	and	CC
cord-003091-uvfppirt	296	37	autoreactive	autoreactive	JJ
cord-003091-uvfppirt	296	38	T	t	NN
cord-003091-uvfppirt	296	39	cells	cell	NNS
cord-003091-uvfppirt	296	40	by	by	IN
cord-003091-uvfppirt	296	41	Fas	Fas	NNP
cord-003091-uvfppirt	296	42	contributes	contribute	VBZ
cord-003091-uvfppirt	296	43	to	to	IN
cord-003091-uvfppirt	296	44	prevention	prevention	NN
cord-003091-uvfppirt	296	45	of	of	IN
cord-003091-uvfppirt	296	46	autoimmunity	autoimmunity	NN
cord-003091-uvfppirt	297	1	Most	Most	JJS
cord-003091-uvfppirt	297	2	microbe	microbe	NN
cord-003091-uvfppirt	297	3	-	-	HYPH
cord-003091-uvfppirt	297	4	specific	specific	JJ
cord-003091-uvfppirt	297	5	naïve	naïve	JJ
cord-003091-uvfppirt	297	6	CD4	CD4	NNP
cord-003091-uvfppirt	297	7	+	+	CC
cord-003091-uvfppirt	297	8	T	t	NN
cord-003091-uvfppirt	297	9	cells	cell	NNS
cord-003091-uvfppirt	297	10	produce	produce	VBP
cord-003091-uvfppirt	297	11	memory	memory	NN
cord-003091-uvfppirt	297	12	cells	cell	NNS
cord-003091-uvfppirt	297	13	during	during	IN
cord-003091-uvfppirt	297	14	infection	infection	NN
cord-003091-uvfppirt	298	1	Alum	alum	NN
cord-003091-uvfppirt	298	2	:	:	:
cord-003091-uvfppirt	298	3	an	an	DT
cord-003091-uvfppirt	298	4	old	old	JJ
cord-003091-uvfppirt	298	5	dog	dog	NN
cord-003091-uvfppirt	298	6	with	with	IN
cord-003091-uvfppirt	298	7	new	new	JJ
cord-003091-uvfppirt	298	8	tricks	trick	NNS
cord-003091-uvfppirt	298	9	Cutting	cut	VBG
cord-003091-uvfppirt	298	10	edge	edge	NN
cord-003091-uvfppirt	298	11	:	:	:
cord-003091-uvfppirt	298	12	alum	alum	NN
cord-003091-uvfppirt	298	13	adjuvant	adjuvant	NN
cord-003091-uvfppirt	298	14	stimulates	stimulate	VBZ
cord-003091-uvfppirt	298	15	inflammatory	inflammatory	JJ
cord-003091-uvfppirt	298	16	dendritic	dendritic	JJ
cord-003091-uvfppirt	298	17	cells	cell	NNS
cord-003091-uvfppirt	298	18	through	through	IN
cord-003091-uvfppirt	298	19	activation	activation	NN
cord-003091-uvfppirt	298	20	of	of	IN
cord-003091-uvfppirt	298	21	the	the	DT
cord-003091-uvfppirt	298	22	NALP3	NALP3	NNP
cord-003091-uvfppirt	298	23	inflammasome	inflammasome	NNP
cord-003091-uvfppirt	298	24	Cutting	cutting	NN
cord-003091-uvfppirt	298	25	edge	edge	NN
cord-003091-uvfppirt	298	26	:	:	:
cord-003091-uvfppirt	298	27	inflammasome	inflammasome	NNP
cord-003091-uvfppirt	298	28	activation	activation	NN
cord-003091-uvfppirt	298	29	by	by	IN
cord-003091-uvfppirt	298	30	alum	alum	NN
cord-003091-uvfppirt	298	31	and	and	CC
cord-003091-uvfppirt	298	32	alum	alum	NN
cord-003091-uvfppirt	298	33	's	's	POS
cord-003091-uvfppirt	298	34	adjuvant	adjuvant	JJ
cord-003091-uvfppirt	298	35	effect	effect	NN
cord-003091-uvfppirt	298	36	are	be	VBP
cord-003091-uvfppirt	298	37	mediated	mediate	VBN
cord-003091-uvfppirt	298	38	by	by	IN
cord-003091-uvfppirt	298	39	NLRP3	nlrp3	XX
cord-003091-uvfppirt	299	1	The	the	DT
cord-003091-uvfppirt	299	2	Nlrp3	nlrp3	JJ
cord-003091-uvfppirt	299	3	inflammasome	inflammasome	NN
cord-003091-uvfppirt	299	4	is	be	VBZ
cord-003091-uvfppirt	299	5	critical	critical	JJ
cord-003091-uvfppirt	299	6	for	for	IN
cord-003091-uvfppirt	299	7	aluminum	aluminum	NN
cord-003091-uvfppirt	299	8	hydroxide	hydroxide	NN
cord-003091-uvfppirt	299	9	-	-	HYPH
cord-003091-uvfppirt	299	10	mediated	mediate	VBN
cord-003091-uvfppirt	299	11	IL-1β	IL-1β	JJR
cord-003091-uvfppirt	299	12	secretion	secretion	NN
cord-003091-uvfppirt	299	13	but	but	CC
cord-003091-uvfppirt	299	14	dispensable	dispensable	JJ
cord-003091-uvfppirt	299	15	for	for	IN
cord-003091-uvfppirt	299	16	adjuvant	adjuvant	JJ
cord-003091-uvfppirt	299	17	activity	activity	NN
cord-003091-uvfppirt	299	18	DNA	dna	NN
cord-003091-uvfppirt	299	19	released	release	VBN
cord-003091-uvfppirt	299	20	from	from	IN
cord-003091-uvfppirt	299	21	dying	die	VBG
cord-003091-uvfppirt	299	22	host	host	NN
cord-003091-uvfppirt	299	23	cells	cell	NNS
cord-003091-uvfppirt	299	24	mediates	mediate	VBZ
cord-003091-uvfppirt	299	25	aluminum	aluminum	NN
cord-003091-uvfppirt	299	26	adjuvant	adjuvant	NN
cord-003091-uvfppirt	299	27	activity	activity	NN
cord-003091-uvfppirt	299	28	Adjuvantenhanced	Adjuvantenhanced	NNP
cord-003091-uvfppirt	299	29	antibody	antibody	NN
cord-003091-uvfppirt	299	30	receptor	receptor	NN
cord-003091-uvfppirt	299	31	signaling	signal	VBG
cord-003091-uvfppirt	299	32	Alum	Alum	NNP
cord-003091-uvfppirt	299	33	induces	induce	VBZ
cord-003091-uvfppirt	299	34	innate	innate	JJ
cord-003091-uvfppirt	299	35	immune	immune	JJ
cord-003091-uvfppirt	299	36	responses	response	NNS
cord-003091-uvfppirt	299	37	through	through	IN
cord-003091-uvfppirt	299	38	macrophage	macrophage	NN
cord-003091-uvfppirt	299	39	and	and	CC
cord-003091-uvfppirt	299	40	mast	mast	NN
cord-003091-uvfppirt	299	41	cell	cell	NN
cord-003091-uvfppirt	299	42	sensors	sensor	NNS
cord-003091-uvfppirt	299	43	,	,	,
cord-003091-uvfppirt	299	44	but	but	CC
cord-003091-uvfppirt	299	45	these	these	DT
cord-003091-uvfppirt	299	46	sensors	sensor	NNS
cord-003091-uvfppirt	299	47	are	be	VBP
cord-003091-uvfppirt	299	48	not	not	RB
cord-003091-uvfppirt	299	49	required	require	VBN
cord-003091-uvfppirt	299	50	for	for	IN
cord-003091-uvfppirt	299	51	alum	alum	NN
cord-003091-uvfppirt	299	52	to	to	TO
cord-003091-uvfppirt	299	53	act	act	VB
cord-003091-uvfppirt	299	54	as	as	IN
cord-003091-uvfppirt	299	55	an	an	DT
cord-003091-uvfppirt	299	56	adjuvant	adjuvant	NN
cord-003091-uvfppirt	299	57	for	for	IN
cord-003091-uvfppirt	299	58	specific	specific	JJ
cord-003091-uvfppirt	299	59	immunity	immunity	NN
cord-003091-uvfppirt	300	1	The	the	DT
cord-003091-uvfppirt	300	2	Syk	Syk	NNP
cord-003091-uvfppirt	300	3	-	-	HYPH
cord-003091-uvfppirt	300	4	NFAT	NFAT	NNP
cord-003091-uvfppirt	300	5	-	-	HYPH
cord-003091-uvfppirt	300	6	IL-2	IL-2	NNP
cord-003091-uvfppirt	300	7	pathway	pathway	NN
cord-003091-uvfppirt	300	8	in	in	IN
cord-003091-uvfppirt	300	9	dendritic	dendritic	JJ
cord-003091-uvfppirt	300	10	cells	cell	NNS
cord-003091-uvfppirt	300	11	is	be	VBZ
cord-003091-uvfppirt	300	12	required	require	VBN
cord-003091-uvfppirt	300	13	for	for	IN
cord-003091-uvfppirt	300	14	optimal	optimal	JJ
cord-003091-uvfppirt	300	15	sterile	sterile	JJ
cord-003091-uvfppirt	300	16	immunity	immunity	NN
cord-003091-uvfppirt	300	17	elicited	elicit	VBN
cord-003091-uvfppirt	300	18	by	by	IN
cord-003091-uvfppirt	300	19	alum	alum	NN
cord-003091-uvfppirt	300	20	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	301	1	Different	different	JJ
cord-003091-uvfppirt	301	2	human	human	JJ
cord-003091-uvfppirt	301	3	vaccine	vaccine	NN
cord-003091-uvfppirt	301	4	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	301	5	promote	promote	VBP
cord-003091-uvfppirt	301	6	distinct	distinct	JJ
cord-003091-uvfppirt	301	7	antigen	antigen	NN
cord-003091-uvfppirt	301	8	-	-	HYPH
cord-003091-uvfppirt	301	9	independent	independent	JJ
cord-003091-uvfppirt	301	10	immunological	immunological	JJ
cord-003091-uvfppirt	301	11	signatures	signature	NNS
cord-003091-uvfppirt	301	12	tailored	tailor	VBN
cord-003091-uvfppirt	301	13	to	to	IN
cord-003091-uvfppirt	301	14	different	different	JJ
cord-003091-uvfppirt	301	15	pathogens	pathogen	NNS
cord-003091-uvfppirt	301	16	Vaccine	Vaccine	NNP
cord-003091-uvfppirt	301	17	adjuvant	adjuvant	NN
cord-003091-uvfppirt	301	18	MF59	MF59	NNP
cord-003091-uvfppirt	301	19	promotes	promote	VBZ
cord-003091-uvfppirt	301	20	retention	retention	NN
cord-003091-uvfppirt	301	21	of	of	IN
cord-003091-uvfppirt	301	22	unprocessed	unprocessed	JJ
cord-003091-uvfppirt	301	23	antigen	antigen	NN
cord-003091-uvfppirt	301	24	in	in	IN
cord-003091-uvfppirt	301	25	lymph	lymph	NN
cord-003091-uvfppirt	301	26	node	node	NN
cord-003091-uvfppirt	301	27	macrophage	macrophage	NN
cord-003091-uvfppirt	301	28	compartments	compartment	NNS
cord-003091-uvfppirt	301	29	and	and	CC
cord-003091-uvfppirt	301	30	follicular	follicular	JJ
cord-003091-uvfppirt	301	31	dendritic	dendritic	JJ
cord-003091-uvfppirt	301	32	cells	cell	NNS
cord-003091-uvfppirt	301	33	Vaccine	vaccine	NN
cord-003091-uvfppirt	301	34	adjuvant	adjuvant	NN
cord-003091-uvfppirt	301	35	MF59	MF59	NNP
cord-003091-uvfppirt	301	36	promotes	promote	VBZ
cord-003091-uvfppirt	301	37	the	the	DT
cord-003091-uvfppirt	301	38	intranodal	intranodal	JJ
cord-003091-uvfppirt	301	39	differentiation	differentiation	NN
cord-003091-uvfppirt	301	40	of	of	IN
cord-003091-uvfppirt	301	41	antigen	antigen	NN
cord-003091-uvfppirt	301	42	-	-	HYPH
cord-003091-uvfppirt	301	43	loaded	load	VBN
cord-003091-uvfppirt	301	44	and	and	CC
cord-003091-uvfppirt	301	45	activated	activate	VBN
cord-003091-uvfppirt	301	46	monocyte	monocyte	NNP
cord-003091-uvfppirt	301	47	-	-	HYPH
cord-003091-uvfppirt	301	48	derived	derive	VBN
cord-003091-uvfppirt	301	49	dendritic	dendritic	JJ
cord-003091-uvfppirt	301	50	cells	cell	NNS
cord-003091-uvfppirt	302	1	The	the	DT
cord-003091-uvfppirt	302	2	two	two	CD
cord-003091-uvfppirt	302	3	-	-	HYPH
cord-003091-uvfppirt	302	4	component	component	NN
cord-003091-uvfppirt	302	5	adjuvant	adjuvant	NN
cord-003091-uvfppirt	303	1	IC31	IC31	NNP
cord-003091-uvfppirt	303	2	®	®	POS
cord-003091-uvfppirt	303	3	boosts	boost	VBZ
cord-003091-uvfppirt	303	4	type	type	NN
cord-003091-uvfppirt	304	1	I	-PRON-	PRP
cord-003091-uvfppirt	304	2	interferon	interferon	VBD
cord-003091-uvfppirt	304	3	production	production	NN
cord-003091-uvfppirt	304	4	of	of	IN
cord-003091-uvfppirt	304	5	human	human	JJ
cord-003091-uvfppirt	304	6	monocyte	monocyte	NNP
cord-003091-uvfppirt	304	7	-	-	HYPH
cord-003091-uvfppirt	304	8	derived	derive	VBN
cord-003091-uvfppirt	304	9	dendritic	dendritic	JJ
cord-003091-uvfppirt	304	10	cells	cell	NNS
cord-003091-uvfppirt	304	11	via	via	IN
cord-003091-uvfppirt	304	12	ligation	ligation	NN
cord-003091-uvfppirt	304	13	of	of	IN
cord-003091-uvfppirt	304	14	endosomal	endosomal	NNP
cord-003091-uvfppirt	304	15	TLRs	TLRs	NNP
cord-003091-uvfppirt	304	16	PEGylation	PEGylation	NNP
cord-003091-uvfppirt	304	17	of	of	IN
cord-003091-uvfppirt	304	18	a	a	DT
cord-003091-uvfppirt	304	19	TLR2-agonist	tlr2-agonist	NN
cord-003091-uvfppirt	304	20	-	-	HYPH
cord-003091-uvfppirt	304	21	based	base	VBN
cord-003091-uvfppirt	304	22	vaccine	vaccine	NN
cord-003091-uvfppirt	304	23	delivery	delivery	NN
cord-003091-uvfppirt	304	24	system	system	NN
cord-003091-uvfppirt	304	25	improves	improve	VBZ
cord-003091-uvfppirt	304	26	anti	anti	JJ
cord-003091-uvfppirt	304	27	gen	gen	NNP
cord-003091-uvfppirt	304	28	trafficking	trafficking	NN
cord-003091-uvfppirt	304	29	and	and	CC
cord-003091-uvfppirt	304	30	the	the	DT
cord-003091-uvfppirt	304	31	magnitude	magnitude	NN
cord-003091-uvfppirt	304	32	of	of	IN
cord-003091-uvfppirt	304	33	ensuing	ensue	VBG
cord-003091-uvfppirt	304	34	antibody	antibody	NN
cord-003091-uvfppirt	304	35	and	and	CC
cord-003091-uvfppirt	304	36	CD8+T	cd8+t	JJ
cord-003091-uvfppirt	304	37	cell	cell	NN
cord-003091-uvfppirt	304	38	responses	response	NNS
cord-003091-uvfppirt	305	1	The	the	DT
cord-003091-uvfppirt	305	2	TLR2/6	TLR2/6	NNP
cord-003091-uvfppirt	305	3	ligand	ligand	NN
cord-003091-uvfppirt	305	4	PAM2CSK4	pam2csk4	NN
cord-003091-uvfppirt	305	5	is	be	VBZ
cord-003091-uvfppirt	305	6	a	a	DT
cord-003091-uvfppirt	305	7	Th2	th2	NN
cord-003091-uvfppirt	305	8	polarizing	polarize	VBG
cord-003091-uvfppirt	305	9	adjuvant	adjuvant	NN
cord-003091-uvfppirt	305	10	in	in	IN
cord-003091-uvfppirt	305	11	Leishmania	Leishmania	NNP
cord-003091-uvfppirt	305	12	major	major	NN
cord-003091-uvfppirt	305	13	and	and	CC
cord-003091-uvfppirt	305	14	Brugia	Brugia	NNP
cord-003091-uvfppirt	305	15	malayi	malayi	NN
cord-003091-uvfppirt	305	16	murine	murine	JJ
cord-003091-uvfppirt	305	17	vaccine	vaccine	NN
cord-003091-uvfppirt	305	18	models	model	NNS
cord-003091-uvfppirt	306	1	Defined	define	VBN
cord-003091-uvfppirt	306	2	TLR3-specific	TLR3-specific	NNP
cord-003091-uvfppirt	306	3	adjuvant	adjuvant	NN
cord-003091-uvfppirt	306	4	that	that	WDT
cord-003091-uvfppirt	306	5	induces	induce	VBZ
cord-003091-uvfppirt	306	6	NK	NK	NNP
cord-003091-uvfppirt	306	7	and	and	CC
cord-003091-uvfppirt	306	8	CTL	CTL	NNP
cord-003091-uvfppirt	306	9	activation	activation	NN
cord-003091-uvfppirt	306	10	without	without	IN
cord-003091-uvfppirt	306	11	significant	significant	JJ
cord-003091-uvfppirt	306	12	cytokine	cytokine	NN
cord-003091-uvfppirt	306	13	production	production	NN
cord-003091-uvfppirt	306	14	in	in	IN
cord-003091-uvfppirt	306	15	vivo	vivo	NN
cord-003091-uvfppirt	306	16	Using	use	VBG
cord-003091-uvfppirt	306	17	3	3	CD
cord-003091-uvfppirt	306	18	TLR	TLR	NNP
cord-003091-uvfppirt	306	19	ligands	ligand	NNS
cord-003091-uvfppirt	306	20	as	as	IN
cord-003091-uvfppirt	306	21	a	a	DT
cord-003091-uvfppirt	306	22	combination	combination	NN
cord-003091-uvfppirt	306	23	adjuvant	adjuvant	NN
cord-003091-uvfppirt	307	1	induces	induce	VBZ
cord-003091-uvfppirt	307	2	qualitative	qualitative	JJ
cord-003091-uvfppirt	307	3	changes	change	NNS
cord-003091-uvfppirt	307	4	in	in	IN
cord-003091-uvfppirt	307	5	T	T	NNP
cord-003091-uvfppirt	307	6	cell	cell	NN
cord-003091-uvfppirt	307	7	responses	response	NNS
cord-003091-uvfppirt	307	8	needed	need	VBN
cord-003091-uvfppirt	307	9	for	for	IN
cord-003091-uvfppirt	307	10	antiviral	antiviral	JJ
cord-003091-uvfppirt	307	11	protection	protection	NN
cord-003091-uvfppirt	307	12	in	in	IN
cord-003091-uvfppirt	307	13	mice	mouse	NNS
cord-003091-uvfppirt	308	1	The	the	DT
cord-003091-uvfppirt	308	2	science	science	NN
cord-003091-uvfppirt	308	3	of	of	IN
cord-003091-uvfppirt	308	4	vaccine	vaccine	NN
cord-003091-uvfppirt	308	5	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	308	6	:	:	:
cord-003091-uvfppirt	308	7	advances	advance	NNS
cord-003091-uvfppirt	308	8	in	in	IN
cord-003091-uvfppirt	308	9	TLR4	TLR4	NNP
cord-003091-uvfppirt	308	10	ligand	ligand	NN
cord-003091-uvfppirt	308	11	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	308	12	Functional	functional	JJ
cord-003091-uvfppirt	308	13	properties	property	NNS
cord-003091-uvfppirt	308	14	of	of	IN
cord-003091-uvfppirt	308	15	flagellin	flagellin	NNP
cord-003091-uvfppirt	308	16	as	as	IN
cord-003091-uvfppirt	308	17	a	a	DT
cord-003091-uvfppirt	308	18	stimulator	stimulator	NN
cord-003091-uvfppirt	308	19	of	of	IN
cord-003091-uvfppirt	308	20	innate	innate	JJ
cord-003091-uvfppirt	308	21	immunity	immunity	NN
cord-003091-uvfppirt	308	22	Novel	Novel	NNP
cord-003091-uvfppirt	308	23	adjuvant	adjuvant	NN
cord-003091-uvfppirt	309	1	Alum	Alum	NNP
cord-003091-uvfppirt	309	2	-	-	HYPH
cord-003091-uvfppirt	309	3	TLR7	TLR7	NNP
cord-003091-uvfppirt	309	4	significantly	significantly	RB
cord-003091-uvfppirt	309	5	potentiates	potentiate	VBZ
cord-003091-uvfppirt	309	6	immune	immune	JJ
cord-003091-uvfppirt	309	7	response	response	NN
cord-003091-uvfppirt	309	8	to	to	IN
cord-003091-uvfppirt	309	9	glycoconjugate	glycoconjugate	JJ
cord-003091-uvfppirt	309	10	vaccines	vaccine	NNS
cord-003091-uvfppirt	309	11	Vaccine	Vaccine	NNP
cord-003091-uvfppirt	309	12	composition	composition	NN
cord-003091-uvfppirt	309	13	formulated	formulate	VBN
cord-003091-uvfppirt	309	14	with	with	IN
cord-003091-uvfppirt	309	15	a	a	DT
cord-003091-uvfppirt	309	16	novel	novel	JJ
cord-003091-uvfppirt	309	17	TLR7-dependent	tlr7-dependent	NN
cord-003091-uvfppirt	309	18	adjuvant	adjuvant	NN
cord-003091-uvfppirt	309	19	induces	induce	VBZ
cord-003091-uvfppirt	309	20	high	high	JJ
cord-003091-uvfppirt	309	21	and	and	CC
cord-003091-uvfppirt	309	22	broad	broad	JJ
cord-003091-uvfppirt	309	23	protection	protection	NN
cord-003091-uvfppirt	309	24	against	against	IN
cord-003091-uvfppirt	309	25	Staphylococcus	Staphylococcus	NNP
cord-003091-uvfppirt	309	26	aureus	aureus	NN
cord-003091-uvfppirt	310	1	A	a	DT
cord-003091-uvfppirt	310	2	Formulated	formulate	VBN
cord-003091-uvfppirt	310	3	TLR7/8	TLR7/8	NNP
cord-003091-uvfppirt	310	4	agonist	agonist	NN
cord-003091-uvfppirt	310	5	is	be	VBZ
cord-003091-uvfppirt	310	6	a	a	DT
cord-003091-uvfppirt	310	7	flexible	flexible	JJ
cord-003091-uvfppirt	310	8	,	,	,
cord-003091-uvfppirt	310	9	highly	highly	RB
cord-003091-uvfppirt	310	10	potent	potent	JJ
cord-003091-uvfppirt	310	11	and	and	CC
cord-003091-uvfppirt	310	12	effective	effective	JJ
cord-003091-uvfppirt	310	13	adjuvant	adjuvant	NN
cord-003091-uvfppirt	310	14	for	for	IN
cord-003091-uvfppirt	310	15	pandemic	pandemic	NN
cord-003091-uvfppirt	310	16	influenza	influenza	NN
cord-003091-uvfppirt	310	17	vaccines	vaccine	NNS
cord-003091-uvfppirt	311	1	A	a	DT
cord-003091-uvfppirt	311	2	TLR9	TLR9	NNP
cord-003091-uvfppirt	311	3	agonist	agonist	NN
cord-003091-uvfppirt	311	4	enhances	enhance	VBZ
cord-003091-uvfppirt	311	5	the	the	DT
cord-003091-uvfppirt	311	6	anti	anti	JJ
cord-003091-uvfppirt	311	7	-	-	JJ
cord-003091-uvfppirt	311	8	tumor	tumor	JJ
cord-003091-uvfppirt	311	9	immunity	immunity	NN
cord-003091-uvfppirt	311	10	of	of	IN
cord-003091-uvfppirt	311	11	peptide	peptide	NN
cord-003091-uvfppirt	311	12	and	and	CC
cord-003091-uvfppirt	311	13	lipopeptide	lipopeptide	JJ
cord-003091-uvfppirt	311	14	vaccines	vaccine	NNS
cord-003091-uvfppirt	311	15	via	via	IN
cord-003091-uvfppirt	311	16	different	different	JJ
cord-003091-uvfppirt	311	17	mechanisms	mechanism	NNS
cord-003091-uvfppirt	312	1	A	a	DT
cord-003091-uvfppirt	312	2	dual	dual	JJ
cord-003091-uvfppirt	312	3	TLR	TLR	NNP
cord-003091-uvfppirt	312	4	agonist	agonist	NN
cord-003091-uvfppirt	312	5	adjuvant	adjuvant	NN
cord-003091-uvfppirt	312	6	enhances	enhance	VBZ
cord-003091-uvfppirt	312	7	the	the	DT
cord-003091-uvfppirt	312	8	immunogenicity	immunogenicity	NN
cord-003091-uvfppirt	312	9	and	and	CC
cord-003091-uvfppirt	312	10	protective	protective	JJ
cord-003091-uvfppirt	312	11	efficacy	efficacy	NN
cord-003091-uvfppirt	312	12	of	of	IN
cord-003091-uvfppirt	312	13	the	the	DT
cord-003091-uvfppirt	312	14	tuberculosis	tuberculosis	NN
cord-003091-uvfppirt	312	15	vaccine	vaccine	NN
cord-003091-uvfppirt	312	16	antigen	antigen	NNP
cord-003091-uvfppirt	313	1	ID93	ID93	NNP
cord-003091-uvfppirt	313	2	The	the	DT
cord-003091-uvfppirt	313	3	toll	toll	NN
cord-003091-uvfppirt	313	4	-	-	HYPH
cord-003091-uvfppirt	313	5	like	like	JJ
cord-003091-uvfppirt	313	6	receptor	receptor	NN
cord-003091-uvfppirt	313	7	4	4	CD
cord-003091-uvfppirt	313	8	agonist	agonist	NN
cord-003091-uvfppirt	313	9	monophosphoryl	monophosphoryl	NNP
cord-003091-uvfppirt	313	10	lipid	lipid	VBG
cord-003091-uvfppirt	313	11	a	a	DT
cord-003091-uvfppirt	313	12	augments	augment	NNS
cord-003091-uvfppirt	313	13	innate	innate	JJ
cord-003091-uvfppirt	313	14	host	host	NN
cord-003091-uvfppirt	313	15	resistance	resistance	NN
cord-003091-uvfppirt	313	16	to	to	IN
cord-003091-uvfppirt	313	17	systemic	systemic	JJ
cord-003091-uvfppirt	313	18	bacterial	bacterial	JJ
cord-003091-uvfppirt	313	19	infection	infection	NN
cord-003091-uvfppirt	313	20	TLR4	TLR4	NNP
cord-003091-uvfppirt	313	21	ligands	ligand	NNS
cord-003091-uvfppirt	313	22	lipopolysaccharide	lipopolysaccharide	NN
cord-003091-uvfppirt	313	23	and	and	CC
cord-003091-uvfppirt	314	1	monophosphoryl	monophosphoryl	NNP
cord-003091-uvfppirt	314	2	lipid	lipid	VBG
cord-003091-uvfppirt	314	3	A	a	DT
cord-003091-uvfppirt	314	4	differentially	differentially	RB
cord-003091-uvfppirt	314	5	regulate	regulate	VBP
cord-003091-uvfppirt	314	6	effector	effector	NN
cord-003091-uvfppirt	314	7	and	and	CC
cord-003091-uvfppirt	314	8	memory	memory	NN
cord-003091-uvfppirt	315	1	CD8	CD8	NNP
cord-003091-uvfppirt	315	2	+	+	CC
cord-003091-uvfppirt	315	3	T	T	NNP
cord-003091-uvfppirt	315	4	cell	cell	NN
cord-003091-uvfppirt	315	5	differentiation	differentiation	NN
cord-003091-uvfppirt	315	6	Co	co	NN
cord-003091-uvfppirt	315	7	-	-	NN
cord-003091-uvfppirt	315	8	delivery	delivery	NN
cord-003091-uvfppirt	315	9	of	of	IN
cord-003091-uvfppirt	315	10	cancer	cancer	NN
cord-003091-uvfppirt	315	11	-	-	HYPH
cord-003091-uvfppirt	315	12	associated	associate	VBN
cord-003091-uvfppirt	315	13	antigen	antigen	NN
cord-003091-uvfppirt	315	14	and	and	CC
cord-003091-uvfppirt	315	15	toll	toll	NN
cord-003091-uvfppirt	315	16	-	-	HYPH
cord-003091-uvfppirt	315	17	like	like	JJ
cord-003091-uvfppirt	316	1	receptor	receptor	NN
cord-003091-uvfppirt	316	2	4	4	CD
cord-003091-uvfppirt	316	3	ligand	ligand	NN
cord-003091-uvfppirt	316	4	in	in	IN
cord-003091-uvfppirt	316	5	PLGA	PLGA	NNP
cord-003091-uvfppirt	316	6	nanoparticles	nanoparticle	NNS
cord-003091-uvfppirt	316	7	induces	induce	VBZ
cord-003091-uvfppirt	316	8	potent	potent	JJ
cord-003091-uvfppirt	316	9	CD8+T	cd8+t	JJ
cord-003091-uvfppirt	316	10	cell	cell	NN
cord-003091-uvfppirt	316	11	-	-	HYPH
cord-003091-uvfppirt	316	12	mediated	mediate	VBN
cord-003091-uvfppirt	316	13	anti	anti	JJ
cord-003091-uvfppirt	316	14	-	-	JJ
cord-003091-uvfppirt	316	15	tumor	tumor	JJ
cord-003091-uvfppirt	316	16	immunity	immunity	NN
cord-003091-uvfppirt	316	17	Inducible	inducible	JJ
cord-003091-uvfppirt	316	18	IL-2	il-2	NN
cord-003091-uvfppirt	316	19	production	production	NN
cord-003091-uvfppirt	316	20	by	by	IN
cord-003091-uvfppirt	316	21	dendritic	dendritic	JJ
cord-003091-uvfppirt	316	22	cells	cell	NNS
cord-003091-uvfppirt	316	23	revealed	reveal	VBN
cord-003091-uvfppirt	316	24	by	by	IN
cord-003091-uvfppirt	316	25	global	global	JJ
cord-003091-uvfppirt	316	26	gene	gene	NN
cord-003091-uvfppirt	316	27	expression	expression	NN
cord-003091-uvfppirt	316	28	analysis	analysis	NN
cord-003091-uvfppirt	316	29	Regulation	regulation	NN
cord-003091-uvfppirt	316	30	and	and	CC
cord-003091-uvfppirt	316	31	dysregulation	dysregulation	NN
cord-003091-uvfppirt	316	32	of	of	IN
cord-003091-uvfppirt	316	33	innate	innate	JJ
cord-003091-uvfppirt	316	34	immunity	immunity	NN
cord-003091-uvfppirt	316	35	by	by	IN
cord-003091-uvfppirt	316	36	NFAT	NFAT	NNP
cord-003091-uvfppirt	316	37	signaling	signal	VBG
cord-003091-uvfppirt	316	38	downstream	downstream	NN
cord-003091-uvfppirt	316	39	of	of	IN
cord-003091-uvfppirt	316	40	pattern	pattern	NN
cord-003091-uvfppirt	316	41	recognition	recognition	NN
cord-003091-uvfppirt	316	42	receptors	receptor	NNS
cord-003091-uvfppirt	316	43	(	(	-LRB-
cord-003091-uvfppirt	316	44	PRRs	PRRs	NNP
cord-003091-uvfppirt	316	45	)	)	-RRB-
cord-003091-uvfppirt	317	1	A	a	DT
cord-003091-uvfppirt	317	2	role	role	NN
cord-003091-uvfppirt	317	3	for	for	IN
cord-003091-uvfppirt	317	4	interleukin-2	interleukin-2	JJ
cord-003091-uvfppirt	317	5	trans	trans	JJ
cord-003091-uvfppirt	317	6	-	-	NN
cord-003091-uvfppirt	317	7	presentation	presentation	NN
cord-003091-uvfppirt	317	8	in	in	IN
cord-003091-uvfppirt	317	9	dendritic	dendritic	JJ
cord-003091-uvfppirt	317	10	cell	cell	NN
cord-003091-uvfppirt	317	11	-	-	HYPH
cord-003091-uvfppirt	317	12	mediated	mediate	VBN
cord-003091-uvfppirt	317	13	T	T	NNP
cord-003091-uvfppirt	317	14	cell	cell	NN
cord-003091-uvfppirt	317	15	activation	activation	NN
cord-003091-uvfppirt	317	16	in	in	IN
cord-003091-uvfppirt	317	17	humans	human	NNS
cord-003091-uvfppirt	317	18	,	,	,
cord-003091-uvfppirt	317	19	as	as	IN
cord-003091-uvfppirt	317	20	revealed	reveal	VBN
cord-003091-uvfppirt	317	21	by	by	IN
cord-003091-uvfppirt	317	22	daclizumab	daclizumab	JJ
cord-003091-uvfppirt	317	23	therapy	therapy	NN
cord-003091-uvfppirt	317	24	immunity	immunity	NN
cord-003091-uvfppirt	317	25	and	and	CC
cord-003091-uvfppirt	317	26	cancer	cancer	NN
cord-003091-uvfppirt	318	1	:	:	:
cord-003091-uvfppirt	318	2	a	a	DT
cord-003091-uvfppirt	318	3	transcription	transcription	NN
cord-003091-uvfppirt	318	4	factor	factor	NN
cord-003091-uvfppirt	318	5	comes	come	VBZ
cord-003091-uvfppirt	318	6	of	of	IN
cord-003091-uvfppirt	318	7	age	age	NN
cord-003091-uvfppirt	318	8	Dectin-1	Dectin-1	NNP
cord-003091-uvfppirt	318	9	stimulation	stimulation	NN
cord-003091-uvfppirt	318	10	by	by	IN
cord-003091-uvfppirt	318	11	Candida	Candida	NNP
cord-003091-uvfppirt	318	12	albicans	albican	NNS
cord-003091-uvfppirt	318	13	yeast	yeast	NN
cord-003091-uvfppirt	318	14	or	or	CC
cord-003091-uvfppirt	318	15	zymosan	zymosan	NNP
cord-003091-uvfppirt	318	16	triggers	trigger	VBZ
cord-003091-uvfppirt	318	17	NFAT	NFAT	NNP
cord-003091-uvfppirt	318	18	activation	activation	NN
cord-003091-uvfppirt	318	19	in	in	IN
cord-003091-uvfppirt	318	20	macrophages	macrophage	NNS
cord-003091-uvfppirt	318	21	and	and	CC
cord-003091-uvfppirt	318	22	dendritic	dendritic	JJ
cord-003091-uvfppirt	318	23	cells	cell	NNS
cord-003091-uvfppirt	319	1	Calcineurin	Calcineurin	NNP
cord-003091-uvfppirt	319	2	regulates	regulate	VBZ
cord-003091-uvfppirt	319	3	innate	innate	JJ
cord-003091-uvfppirt	319	4	antifungal	antifungal	JJ
cord-003091-uvfppirt	319	5	immunity	immunity	NN
cord-003091-uvfppirt	319	6	in	in	IN
cord-003091-uvfppirt	319	7	neutrophils	neutrophil	NNS
cord-003091-uvfppirt	320	1	Dectin-2	Dectin-2	NNPS
cord-003091-uvfppirt	320	2	is	be	VBZ
cord-003091-uvfppirt	320	3	a	a	DT
cord-003091-uvfppirt	320	4	direct	direct	JJ
cord-003091-uvfppirt	320	5	receptor	receptor	NN
cord-003091-uvfppirt	320	6	for	for	IN
cord-003091-uvfppirt	320	7	mannose	mannose	NN
cord-003091-uvfppirt	320	8	-	-	HYPH
cord-003091-uvfppirt	320	9	capped	cap	VBN
cord-003091-uvfppirt	320	10	lipoarabinomannan	lipoarabinomannan	NN
cord-003091-uvfppirt	320	11	of	of	IN
cord-003091-uvfppirt	320	12	mycobacteria	mycobacteria	NNP
cord-003091-uvfppirt	320	13	Phagocytosis	Phagocytosis	NNP
cord-003091-uvfppirt	320	14	-	-	HYPH
cord-003091-uvfppirt	320	15	dependent	dependent	JJ
cord-003091-uvfppirt	320	16	activation	activation	NN
cord-003091-uvfppirt	320	17	of	of	IN
cord-003091-uvfppirt	320	18	a	a	DT
cord-003091-uvfppirt	320	19	TLR9-BTK	TLR9-BTK	NNP
cord-003091-uvfppirt	320	20	-	-	HYPH
cord-003091-uvfppirt	320	21	calcineurin	calcineurin	NN
cord-003091-uvfppirt	320	22	-	-	HYPH
cord-003091-uvfppirt	320	23	NFAT	NFAT	NNP
cord-003091-uvfppirt	320	24	pathway	pathway	NN
cord-003091-uvfppirt	320	25	co	co	NN
cord-003091-uvfppirt	320	26	-	-	JJ
cord-003091-uvfppirt	320	27	ordinates	ordinates	JJ
cord-003091-uvfppirt	320	28	innate	innate	JJ
cord-003091-uvfppirt	320	29	immunity	immunity	NN
cord-003091-uvfppirt	320	30	to	to	IN
cord-003091-uvfppirt	320	31	Aspergillus	aspergillus	NN
cord-003091-uvfppirt	320	32	fumigatus	fumigatus	NN
cord-003091-uvfppirt	320	33	Skin	skin	NN
cord-003091-uvfppirt	320	34	infections	infection	NNS
cord-003091-uvfppirt	320	35	are	be	VBP
cord-003091-uvfppirt	320	36	eliminated	eliminate	VBN
cord-003091-uvfppirt	320	37	by	by	IN
cord-003091-uvfppirt	320	38	cooperation	cooperation	NN
cord-003091-uvfppirt	320	39	of	of	IN
cord-003091-uvfppirt	320	40	the	the	DT
cord-003091-uvfppirt	320	41	fibrinolytic	fibrinolytic	JJ
cord-003091-uvfppirt	320	42	and	and	CC
cord-003091-uvfppirt	320	43	innate	innate	JJ
cord-003091-uvfppirt	320	44	immune	immune	JJ
cord-003091-uvfppirt	320	45	systems	system	NNS
cord-003091-uvfppirt	320	46	IL-15	IL-15	NNP
cord-003091-uvfppirt	320	47	cis	cis	NNP
cord-003091-uvfppirt	320	48	presentation	presentation	NN
cord-003091-uvfppirt	320	49	is	be	VBZ
cord-003091-uvfppirt	320	50	required	require	VBN
cord-003091-uvfppirt	320	51	for	for	IN
cord-003091-uvfppirt	320	52	optimal	optimal	JJ
cord-003091-uvfppirt	320	53	NK	NK	NNP
cord-003091-uvfppirt	320	54	cell	cell	NN
cord-003091-uvfppirt	320	55	activation	activation	NN
cord-003091-uvfppirt	320	56	in	in	IN
cord-003091-uvfppirt	320	57	lipopolysaccharide	lipopolysaccharide	NN
cord-003091-uvfppirt	320	58	-	-	HYPH
cord-003091-uvfppirt	320	59	mediated	mediate	VBN
cord-003091-uvfppirt	320	60	inflammatory	inflammatory	JJ
cord-003091-uvfppirt	320	61	conditions	condition	NNS
cord-003091-uvfppirt	321	1	A	a	DT
cord-003091-uvfppirt	321	2	contribution	contribution	NN
cord-003091-uvfppirt	321	3	of	of	IN
cord-003091-uvfppirt	321	4	mouse	mouse	NN
cord-003091-uvfppirt	321	5	dendritic	dendritic	JJ
cord-003091-uvfppirt	321	6	cell	cell	NN
cord-003091-uvfppirt	321	7	-	-	HYPH
cord-003091-uvfppirt	321	8	derived	derive	VBN
cord-003091-uvfppirt	321	9	IL-2	il-2	NN
cord-003091-uvfppirt	321	10	for	for	IN
cord-003091-uvfppirt	321	11	NK	NK	NNP
cord-003091-uvfppirt	321	12	cell	cell	NN
cord-003091-uvfppirt	321	13	activation	activation	NN
cord-003091-uvfppirt	321	14	CD14	CD14	NNP
cord-003091-uvfppirt	321	15	and	and	CC
cord-003091-uvfppirt	321	16	NFAT	NFAT	NNP
cord-003091-uvfppirt	321	17	mediate	mediate	VBP
cord-003091-uvfppirt	321	18	lipopolysaccharide	lipopolysaccharide	NN
cord-003091-uvfppirt	321	19	-	-	HYPH
cord-003091-uvfppirt	321	20	induced	induce	VBN
cord-003091-uvfppirt	321	21	skin	skin	NN
cord-003091-uvfppirt	321	22	edema	edema	NN
cord-003091-uvfppirt	321	23	formation	formation	NN
cord-003091-uvfppirt	321	24	in	in	IN
cord-003091-uvfppirt	321	25	mice	mouse	NNS
cord-003091-uvfppirt	322	1	Prostaglandin	prostaglandin	NN
cord-003091-uvfppirt	322	2	E2	E2	NNP
cord-003091-uvfppirt	322	3	is	be	VBZ
cord-003091-uvfppirt	322	4	generally	generally	RB
cord-003091-uvfppirt	322	5	required	require	VBN
cord-003091-uvfppirt	322	6	for	for	IN
cord-003091-uvfppirt	322	7	human	human	JJ
cord-003091-uvfppirt	322	8	dendritic	dendritic	JJ
cord-003091-uvfppirt	322	9	cell	cell	NN
cord-003091-uvfppirt	322	10	migration	migration	NN
cord-003091-uvfppirt	322	11	and	and	CC
cord-003091-uvfppirt	322	12	exerts	exert	VBZ
cord-003091-uvfppirt	322	13	its	-PRON-	PRP$
cord-003091-uvfppirt	322	14	effect	effect	NN
cord-003091-uvfppirt	322	15	via	via	IN
cord-003091-uvfppirt	322	16	EP2	EP2	NNP
cord-003091-uvfppirt	322	17	and	and	CC
cord-003091-uvfppirt	322	18	EP4	EP4	NNP
cord-003091-uvfppirt	322	19	receptors	receptor	NNS
cord-003091-uvfppirt	323	1	A	a	DT
cord-003091-uvfppirt	323	2	spatially	spatially	RB
cord-003091-uvfppirt	323	3	-	-	HYPH
cord-003091-uvfppirt	323	4	organized	organize	VBN
cord-003091-uvfppirt	323	5	multicellular	multicellular	JJ
cord-003091-uvfppirt	323	6	innate	innate	JJ
cord-003091-uvfppirt	323	7	immune	immune	JJ
cord-003091-uvfppirt	323	8	response	response	NN
cord-003091-uvfppirt	323	9	in	in	IN
cord-003091-uvfppirt	323	10	lymph	lymph	NN
cord-003091-uvfppirt	323	11	nodes	node	NNS
cord-003091-uvfppirt	323	12	limits	limit	VBZ
cord-003091-uvfppirt	323	13	systemic	systemic	JJ
cord-003091-uvfppirt	323	14	pathogen	pathogen	NN
cord-003091-uvfppirt	323	15	spread	spread	VBD
cord-003091-uvfppirt	323	16	Capture	capture	NN
cord-003091-uvfppirt	323	17	of	of	IN
cord-003091-uvfppirt	323	18	influenza	influenza	NN
cord-003091-uvfppirt	323	19	by	by	IN
cord-003091-uvfppirt	323	20	medullary	medullary	JJ
cord-003091-uvfppirt	323	21	dendritic	dendritic	JJ
cord-003091-uvfppirt	323	22	cells	cell	NNS
cord-003091-uvfppirt	323	23	via	via	IN
cord-003091-uvfppirt	323	24	SIGN	sign	NN
cord-003091-uvfppirt	323	25	-	-	HYPH
cord-003091-uvfppirt	323	26	R1	r1	NN
cord-003091-uvfppirt	323	27	is	be	VBZ
cord-003091-uvfppirt	323	28	essential	essential	JJ
cord-003091-uvfppirt	323	29	for	for	IN
cord-003091-uvfppirt	323	30	humoral	humoral	JJ
cord-003091-uvfppirt	323	31	immunity	immunity	NN
cord-003091-uvfppirt	323	32	in	in	IN
cord-003091-uvfppirt	323	33	draining	drain	VBG
cord-003091-uvfppirt	323	34	lymph	lymph	NN
cord-003091-uvfppirt	323	35	nodes	node	NNS
cord-003091-uvfppirt	323	36	Conduits	conduit	NNS
cord-003091-uvfppirt	323	37	mediate	mediate	VBP
cord-003091-uvfppirt	323	38	transport	transport	NN
cord-003091-uvfppirt	323	39	of	of	IN
cord-003091-uvfppirt	323	40	low	low	JJ
cord-003091-uvfppirt	323	41	-	-	HYPH
cord-003091-uvfppirt	323	42	molecular	molecular	JJ
cord-003091-uvfppirt	323	43	-	-	HYPH
cord-003091-uvfppirt	323	44	weight	weight	NN
cord-003091-uvfppirt	323	45	antigen	antigen	NN
cord-003091-uvfppirt	323	46	to	to	IN
cord-003091-uvfppirt	323	47	lymph	lymph	NN
cord-003091-uvfppirt	323	48	node	node	NN
cord-003091-uvfppirt	323	49	follicles	follicle	NNS
cord-003091-uvfppirt	324	1	Strategically	strategically	RB
cord-003091-uvfppirt	324	2	localized	localize	VBN
cord-003091-uvfppirt	324	3	dendritic	dendritic	JJ
cord-003091-uvfppirt	324	4	cells	cell	NNS
cord-003091-uvfppirt	324	5	promote	promote	VBP
cord-003091-uvfppirt	324	6	rapid	rapid	JJ
cord-003091-uvfppirt	324	7	T	t	NN
cord-003091-uvfppirt	324	8	cell	cell	NN
cord-003091-uvfppirt	324	9	responses	response	NNS
cord-003091-uvfppirt	324	10	to	to	IN
cord-003091-uvfppirt	324	11	lymph	lymph	NN
cord-003091-uvfppirt	324	12	-	-	HYPH
cord-003091-uvfppirt	324	13	borne	bear	VBN
cord-003091-uvfppirt	324	14	particulate	particulate	NN
cord-003091-uvfppirt	324	15	antigens	antigen	NNS
cord-003091-uvfppirt	324	16	Histo	histo	NN
cord-003091-uvfppirt	324	17	-	-	HYPH
cord-003091-uvfppirt	324	18	cytometry	cytometry	NN
cord-003091-uvfppirt	324	19	:	:	:
cord-003091-uvfppirt	324	20	a	a	DT
cord-003091-uvfppirt	324	21	method	method	NN
cord-003091-uvfppirt	324	22	for	for	IN
cord-003091-uvfppirt	324	23	highly	highly	RB
cord-003091-uvfppirt	324	24	multiplex	multiplex	JJ
cord-003091-uvfppirt	324	25	quantitative	quantitative	JJ
cord-003091-uvfppirt	324	26	tissue	tissue	NN
cord-003091-uvfppirt	324	27	imaging	imaging	NN
cord-003091-uvfppirt	324	28	analysis	analysis	NN
cord-003091-uvfppirt	324	29	applied	apply	VBN
cord-003091-uvfppirt	324	30	to	to	IN
cord-003091-uvfppirt	324	31	dendritic	dendritic	JJ
cord-003091-uvfppirt	324	32	cell	cell	NN
cord-003091-uvfppirt	324	33	subset	subset	VBN
cord-003091-uvfppirt	324	34	microanatomy	microanatomy	NN
cord-003091-uvfppirt	324	35	in	in	IN
cord-003091-uvfppirt	324	36	lymph	lymph	NN
cord-003091-uvfppirt	324	37	nodes	node	NNS
cord-003091-uvfppirt	325	1	Subcapsular	subcapsular	JJ
cord-003091-uvfppirt	325	2	sinus	sinus	NN
cord-003091-uvfppirt	325	3	macrophages	macrophage	NNS
cord-003091-uvfppirt	325	4	prevent	prevent	VBP
cord-003091-uvfppirt	325	5	CNS	CNS	NNP
cord-003091-uvfppirt	325	6	invasion	invasion	NN
cord-003091-uvfppirt	325	7	on	on	IN
cord-003091-uvfppirt	325	8	peripheral	peripheral	JJ
cord-003091-uvfppirt	325	9	infection	infection	NN
cord-003091-uvfppirt	325	10	with	with	IN
cord-003091-uvfppirt	325	11	a	a	DT
cord-003091-uvfppirt	325	12	neurotropic	neurotropic	NNP
cord-003091-uvfppirt	325	13	virus	virus	NN
cord-003091-uvfppirt	325	14	The	the	DT
cord-003091-uvfppirt	325	15	conduit	conduit	NN
cord-003091-uvfppirt	325	16	system	system	NN
cord-003091-uvfppirt	325	17	transports	transport	VBZ
cord-003091-uvfppirt	325	18	soluble	soluble	JJ
cord-003091-uvfppirt	325	19	antigens	antigen	NNS
cord-003091-uvfppirt	325	20	from	from	IN
cord-003091-uvfppirt	325	21	the	the	DT
cord-003091-uvfppirt	325	22	afferent	afferent	JJ
cord-003091-uvfppirt	325	23	lymph	lymph	NN
cord-003091-uvfppirt	325	24	to	to	IN
cord-003091-uvfppirt	325	25	resident	resident	JJ
cord-003091-uvfppirt	325	26	dendritic	dendritic	JJ
cord-003091-uvfppirt	325	27	cells	cell	NNS
cord-003091-uvfppirt	325	28	in	in	IN
cord-003091-uvfppirt	325	29	the	the	DT
cord-003091-uvfppirt	325	30	T	T	NNP
cord-003091-uvfppirt	325	31	cell	cell	NN
cord-003091-uvfppirt	325	32	area	area	NN
cord-003091-uvfppirt	325	33	of	of	IN
cord-003091-uvfppirt	325	34	the	the	DT
cord-003091-uvfppirt	325	35	lymph	lymph	NN
cord-003091-uvfppirt	325	36	node	node	NN
cord-003091-uvfppirt	326	1	Lymph	lymph	NN
cord-003091-uvfppirt	326	2	node	node	NN
cord-003091-uvfppirt	326	3	macrophages	macrophage	NNS
cord-003091-uvfppirt	326	4	restrict	restrict	VBP
cord-003091-uvfppirt	326	5	murine	murine	JJ
cord-003091-uvfppirt	326	6	cytomegalovirus	cytomegalovirus	NN
cord-003091-uvfppirt	326	7	dissemination	dissemination	NN
cord-003091-uvfppirt	327	1	Subcapsular	subcapsular	JJ
cord-003091-uvfppirt	327	2	sinus	sinus	NN
cord-003091-uvfppirt	327	3	macrophages	macrophage	NNS
cord-003091-uvfppirt	327	4	limit	limit	VBP
cord-003091-uvfppirt	327	5	acute	acute	JJ
cord-003091-uvfppirt	327	6	gammaherpesvirus	gammaherpesvirus	JJ
cord-003091-uvfppirt	327	7	dissemination	dissemination	NN
cord-003091-uvfppirt	327	8	Tracking	tracking	NN
cord-003091-uvfppirt	327	9	and	and	CC
cord-003091-uvfppirt	327	10	quantification	quantification	NN
cord-003091-uvfppirt	327	11	of	of	IN
cord-003091-uvfppirt	327	12	dendritic	dendritic	JJ
cord-003091-uvfppirt	327	13	cell	cell	NN
cord-003091-uvfppirt	327	14	migration	migration	NN
cord-003091-uvfppirt	327	15	and	and	CC
cord-003091-uvfppirt	327	16	antigen	antigen	NN
cord-003091-uvfppirt	327	17	trafficking	trafficking	NN
cord-003091-uvfppirt	327	18	between	between	IN
cord-003091-uvfppirt	327	19	the	the	DT
cord-003091-uvfppirt	327	20	skin	skin	NN
cord-003091-uvfppirt	327	21	and	and	CC
cord-003091-uvfppirt	327	22	lymph	lymph	NN
cord-003091-uvfppirt	327	23	nodes	node	NNS
cord-003091-uvfppirt	327	24	Dynamics	dynamic	NNS
cord-003091-uvfppirt	327	25	and	and	CC
cord-003091-uvfppirt	327	26	function	function	NN
cord-003091-uvfppirt	327	27	of	of	IN
cord-003091-uvfppirt	327	28	Langerhans	Langerhans	NNP
cord-003091-uvfppirt	327	29	cells	cell	NNS
cord-003091-uvfppirt	327	30	in	in	IN
cord-003091-uvfppirt	327	31	vivo	vivo	NN
cord-003091-uvfppirt	327	32	:	:	:
cord-003091-uvfppirt	327	33	dermal	dermal	JJ
cord-003091-uvfppirt	327	34	dendritic	dendritic	JJ
cord-003091-uvfppirt	327	35	cells	cell	NNS
cord-003091-uvfppirt	327	36	colonize	colonize	VBP
cord-003091-uvfppirt	327	37	lymph	lymph	NN
cord-003091-uvfppirt	327	38	node	node	NN
cord-003091-uvfppirt	327	39	areasdistinct	areasdistinct	VBN
cord-003091-uvfppirt	327	40	from	from	IN
cord-003091-uvfppirt	327	41	slower	slow	JJR
cord-003091-uvfppirt	327	42	migrating	migrate	VBG
cord-003091-uvfppirt	327	43	Langerhans	Langerhans	NNP
cord-003091-uvfppirt	327	44	cells	cell	VBZ
cord-003091-uvfppirt	327	45	Lymph	lymph	NN
cord-003091-uvfppirt	327	46	-	-	HYPH
cord-003091-uvfppirt	327	47	node	node	NN
cord-003091-uvfppirt	327	48	resident	resident	NN
cord-003091-uvfppirt	327	49	CD8a+	CD8a+	NNP
cord-003091-uvfppirt	327	50	dendritic	dendritic	JJ
cord-003091-uvfppirt	327	51	cells	cell	NNS
cord-003091-uvfppirt	327	52	capture	capture	VBP
cord-003091-uvfppirt	327	53	antigens	antigen	NNS
cord-003091-uvfppirt	327	54	from	from	IN
cord-003091-uvfppirt	327	55	migratory	migratory	JJ
cord-003091-uvfppirt	327	56	malaria	malaria	NN
cord-003091-uvfppirt	327	57	sporozoites	sporozoite	NNS
cord-003091-uvfppirt	327	58	and	and	CC
cord-003091-uvfppirt	327	59	induce	induce	VB
cord-003091-uvfppirt	327	60	CD8	CD8	NNP
cord-003091-uvfppirt	327	61	+	+	CC
cord-003091-uvfppirt	327	62	T	T	NNP
cord-003091-uvfppirt	327	63	cell	cell	NN
cord-003091-uvfppirt	327	64	responses	response	NNS
cord-003091-uvfppirt	327	65	Lymph	lymph	NN
cord-003091-uvfppirt	327	66	node	node	NN
cord-003091-uvfppirt	327	67	resident	resident	NN
cord-003091-uvfppirt	327	68	rather	rather	RB
cord-003091-uvfppirt	327	69	than	than	IN
cord-003091-uvfppirt	328	1	skin	skin	NN
cord-003091-uvfppirt	328	2	-	-	HYPH
cord-003091-uvfppirt	328	3	derived	derive	VBN
cord-003091-uvfppirt	328	4	dendritic	dendritic	JJ
cord-003091-uvfppirt	328	5	cells	cell	NNS
cord-003091-uvfppirt	328	6	initiate	initiate	VBP
cord-003091-uvfppirt	328	7	specific	specific	JJ
cord-003091-uvfppirt	328	8	T	t	NN
cord-003091-uvfppirt	328	9	cell	cell	NN
cord-003091-uvfppirt	328	10	responses	response	NNS
cord-003091-uvfppirt	328	11	after	after	IN
cord-003091-uvfppirt	328	12	Leishmania	Leishmania	NNP
cord-003091-uvfppirt	328	13	major	major	JJ
cord-003091-uvfppirt	328	14	infection	infection	NN
cord-003091-uvfppirt	328	15	Cross	cross	NN
cord-003091-uvfppirt	328	16	-	-	NN
cord-003091-uvfppirt	328	17	presentation	presentation	NN
cord-003091-uvfppirt	328	18	,	,	,
cord-003091-uvfppirt	328	19	dendritic	dendritic	JJ
cord-003091-uvfppirt	328	20	cell	cell	NN
cord-003091-uvfppirt	328	21	subsets	subset	NNS
cord-003091-uvfppirt	328	22	,	,	,
cord-003091-uvfppirt	328	23	and	and	CC
cord-003091-uvfppirt	328	24	the	the	DT
cord-003091-uvfppirt	328	25	generation	generation	NN
cord-003091-uvfppirt	328	26	of	of	IN
cord-003091-uvfppirt	328	27	immunity	immunity	NN
cord-003091-uvfppirt	328	28	to	to	IN
cord-003091-uvfppirt	328	29	cellular	cellular	JJ
cord-003091-uvfppirt	328	30	antigens	antigen	NNS
cord-003091-uvfppirt	328	31	Cross	Cross	NNP
cord-003091-uvfppirt	328	32	-	-	NN
cord-003091-uvfppirt	328	33	presentation	presentation	NN
cord-003091-uvfppirt	328	34	of	of	IN
cord-003091-uvfppirt	328	35	cell	cell	NN
cord-003091-uvfppirt	328	36	-	-	HYPH
cord-003091-uvfppirt	328	37	associated	associate	VBN
cord-003091-uvfppirt	328	38	antigens	antigen	NNS
cord-003091-uvfppirt	328	39	by	by	IN
cord-003091-uvfppirt	328	40	mouse	mouse	NN
cord-003091-uvfppirt	328	41	splenic	splenic	JJ
cord-003091-uvfppirt	328	42	dendritic	dendritic	JJ
cord-003091-uvfppirt	328	43	cell	cell	NN
cord-003091-uvfppirt	328	44	populations	population	NNS
cord-003091-uvfppirt	328	45	CD8+T	cd8+t	IN
cord-003091-uvfppirt	328	46	cells	cell	NNS
cord-003091-uvfppirt	328	47	orchestrate	orchestrate	VBP
cord-003091-uvfppirt	328	48	pDC	pdc	CD
cord-003091-uvfppirt	328	49	-	-	HYPH
cord-003091-uvfppirt	328	50	XCR1+dendritic	XCR1+dendritic	VBN
cord-003091-uvfppirt	328	51	cell	cell	NN
cord-003091-uvfppirt	328	52	spatial	spatial	JJ
cord-003091-uvfppirt	328	53	and	and	CC
cord-003091-uvfppirt	328	54	functional	functional	JJ
cord-003091-uvfppirt	328	55	cooperativity	cooperativity	NN
cord-003091-uvfppirt	328	56	to	to	TO
cord-003091-uvfppirt	328	57	optimize	optimize	VB
cord-003091-uvfppirt	328	58	priming	prime	VBG
cord-003091-uvfppirt	328	59	Migratory	migratory	JJ
cord-003091-uvfppirt	328	60	dendritic	dendritic	JJ
cord-003091-uvfppirt	328	61	cells	cell	NNS
cord-003091-uvfppirt	328	62	transfer	transfer	VBP
cord-003091-uvfppirt	328	63	antigen	antigen	NN
cord-003091-uvfppirt	328	64	to	to	IN
cord-003091-uvfppirt	328	65	a	a	DT
cord-003091-uvfppirt	328	66	lymph	lymph	NN
cord-003091-uvfppirt	328	67	node	node	NN
cord-003091-uvfppirt	328	68	-	-	HYPH
cord-003091-uvfppirt	328	69	resident	resident	JJ
cord-003091-uvfppirt	328	70	dendritic	dendritic	JJ
cord-003091-uvfppirt	328	71	cell	cell	NN
cord-003091-uvfppirt	328	72	population	population	NN
cord-003091-uvfppirt	328	73	for	for	IN
cord-003091-uvfppirt	328	74	efficient	efficient	JJ
cord-003091-uvfppirt	328	75	CTL	CTL	NNP
cord-003091-uvfppirt	328	76	priming	prime	VBG
cord-003091-uvfppirt	328	77	Multiple	multiple	JJ
cord-003091-uvfppirt	328	78	dendritic	dendritic	JJ
cord-003091-uvfppirt	328	79	cell	cell	NN
cord-003091-uvfppirt	328	80	populations	population	NNS
cord-003091-uvfppirt	328	81	activate	activate	VBP
cord-003091-uvfppirt	328	82	CD4	CD4	NNP
cord-003091-uvfppirt	328	83	+	+	CC
cord-003091-uvfppirt	328	84	T	t	NN
cord-003091-uvfppirt	328	85	cells	cell	NNS
cord-003091-uvfppirt	328	86	after	after	IN
cord-003091-uvfppirt	328	87	viral	viral	JJ
cord-003091-uvfppirt	328	88	stimu	stimu	NNP
cord-003091-uvfppirt	328	89	lation	lation	NNP
cord-003091-uvfppirt	328	90	Cross	Cross	NNP
cord-003091-uvfppirt	328	91	-	-	HYPH
cord-003091-uvfppirt	328	92	presentation	presentation	NN
cord-003091-uvfppirt	328	93	of	of	IN
cord-003091-uvfppirt	328	94	viral	viral	JJ
cord-003091-uvfppirt	328	95	and	and	CC
cord-003091-uvfppirt	328	96	self	self	NN
cord-003091-uvfppirt	328	97	antigens	antigen	NNS
cord-003091-uvfppirt	328	98	by	by	IN
cord-003091-uvfppirt	328	99	skin	skin	NN
cord-003091-uvfppirt	328	100	-	-	HYPH
cord-003091-uvfppirt	328	101	derived	derive	VBN
cord-003091-uvfppirt	328	102	CD103	cd103	NN
cord-003091-uvfppirt	328	103	+	+	CD
cord-003091-uvfppirt	328	104	dendritic	dendritic	JJ
cord-003091-uvfppirt	328	105	cells	cell	NNS
cord-003091-uvfppirt	328	106	Imaging	Imaging	NNP
cord-003091-uvfppirt	328	107	of	of	IN
cord-003091-uvfppirt	328	108	the	the	DT
cord-003091-uvfppirt	328	109	cross	cross	NN
cord-003091-uvfppirt	328	110	-	-	JJ
cord-003091-uvfppirt	328	111	presenting	presenting	JJ
cord-003091-uvfppirt	328	112	dendritic	dendritic	JJ
cord-003091-uvfppirt	328	113	cell	cell	NN
cord-003091-uvfppirt	328	114	subsets	subset	NNS
cord-003091-uvfppirt	328	115	in	in	IN
cord-003091-uvfppirt	328	116	the	the	DT
cord-003091-uvfppirt	328	117	skin	skin	NN
cord-003091-uvfppirt	328	118	-	-	HYPH
cord-003091-uvfppirt	328	119	draining	drain	VBG
cord-003091-uvfppirt	328	120	lymph	lymph	NN
cord-003091-uvfppirt	328	121	node	node	NN
cord-003091-uvfppirt	328	122	Resident	Resident	NNP
cord-003091-uvfppirt	328	123	CD8	CD8	NNP
cord-003091-uvfppirt	328	124	+	+	CC
cord-003091-uvfppirt	328	125	and	and	CC
cord-003091-uvfppirt	328	126	migratory	migratory	JJ
cord-003091-uvfppirt	328	127	CD103	cd103	NN
cord-003091-uvfppirt	328	128	+	+	CD
cord-003091-uvfppirt	328	129	dendritic	dendritic	JJ
cord-003091-uvfppirt	328	130	cells	cell	NNS
cord-003091-uvfppirt	328	131	control	control	VBP
cord-003091-uvfppirt	328	132	CD8	CD8	NNP
cord-003091-uvfppirt	328	133	T	T	NNP
cord-003091-uvfppirt	328	134	cell	cell	NN
cord-003091-uvfppirt	328	135	immunity	immunity	NN
cord-003091-uvfppirt	328	136	during	during	IN
cord-003091-uvfppirt	328	137	acute	acute	JJ
cord-003091-uvfppirt	328	138	influenza	influenza	NN
cord-003091-uvfppirt	328	139	infection	infection	NN
cord-003091-uvfppirt	328	140	Human	human	JJ
cord-003091-uvfppirt	328	141	tissues	tissue	NNS
cord-003091-uvfppirt	329	1	contain	contain	VB
cord-003091-uvfppirt	329	2	CD141hiCross	CD141hiCross	NNP
cord-003091-uvfppirt	329	3	-	-	HYPH
cord-003091-uvfppirt	329	4	presenting	present	VBG
cord-003091-uvfppirt	329	5	dendritic	dendritic	JJ
cord-003091-uvfppirt	329	6	cells	cell	NNS
cord-003091-uvfppirt	329	7	with	with	IN
cord-003091-uvfppirt	329	8	functional	functional	JJ
cord-003091-uvfppirt	329	9	homology	homology	NN
cord-003091-uvfppirt	329	10	to	to	TO
cord-003091-uvfppirt	329	11	mouse	mouse	VB
cord-003091-uvfppirt	329	12	CD103+nonlymphoid	CD103+nonlymphoid	NNP
cord-003091-uvfppirt	329	13	dendritic	dendritic	JJ
cord-003091-uvfppirt	329	14	cells	cell	NNS
cord-003091-uvfppirt	329	15	Peripheral	peripheral	JJ
cord-003091-uvfppirt	329	16	CD103	CD103	NNP
cord-003091-uvfppirt	329	17	+	+	CD
cord-003091-uvfppirt	329	18	dendritic	dendritic	JJ
cord-003091-uvfppirt	329	19	cells	cell	NNS
cord-003091-uvfppirt	329	20	form	form	VBP
cord-003091-uvfppirt	329	21	a	a	DT
cord-003091-uvfppirt	329	22	unified	unify	VBN
cord-003091-uvfppirt	329	23	subset	subset	JJ
cord-003091-uvfppirt	329	24	developmentally	developmentally	RB
cord-003091-uvfppirt	329	25	related	related	JJ
cord-003091-uvfppirt	329	26	to	to	IN
cord-003091-uvfppirt	329	27	CD8α	CD8α	NNP
cord-003091-uvfppirt	329	28	+	+	CC
cord-003091-uvfppirt	329	29	conventional	conventional	JJ
cord-003091-uvfppirt	329	30	dendritic	dendritic	JJ
cord-003091-uvfppirt	329	31	cells	cell	NNS
cord-003091-uvfppirt	330	1	Selective	selective	JJ
cord-003091-uvfppirt	330	2	expression	expression	NN
cord-003091-uvfppirt	330	3	of	of	IN
cord-003091-uvfppirt	330	4	the	the	DT
cord-003091-uvfppirt	330	5	chemokine	chemokine	NN
cord-003091-uvfppirt	330	6	receptor	receptor	NN
cord-003091-uvfppirt	330	7	XCR1	XCR1	NNP
cord-003091-uvfppirt	330	8	on	on	IN
cord-003091-uvfppirt	330	9	cross	cross	RB
cord-003091-uvfppirt	330	10	-	-	JJ
cord-003091-uvfppirt	330	11	presenting	presenting	JJ
cord-003091-uvfppirt	330	12	dendritic	dendritic	JJ
cord-003091-uvfppirt	330	13	cells	cell	NNS
cord-003091-uvfppirt	330	14	determines	determine	VBZ
cord-003091-uvfppirt	330	15	cooperation	cooperation	NN
cord-003091-uvfppirt	330	16	with	with	IN
cord-003091-uvfppirt	330	17	CD8	CD8	NNP
cord-003091-uvfppirt	330	18	+	+	CC
cord-003091-uvfppirt	330	19	T	T	NNP
cord-003091-uvfppirt	330	20	cells	cell	NNS
cord-003091-uvfppirt	330	21	CCR6-dependent	CCR6-dependent	NNP
cord-003091-uvfppirt	330	22	recruitment	recruitment	NN
cord-003091-uvfppirt	330	23	of	of	IN
cord-003091-uvfppirt	330	24	blood	blood	NN
cord-003091-uvfppirt	330	25	phagocytes	phagocyte	NNS
cord-003091-uvfppirt	330	26	is	be	VBZ
cord-003091-uvfppirt	330	27	necessary	necessary	JJ
cord-003091-uvfppirt	330	28	for	for	IN
cord-003091-uvfppirt	330	29	rapid	rapid	JJ
cord-003091-uvfppirt	330	30	CD4	CD4	NNP
cord-003091-uvfppirt	330	31	T	T	NNP
cord-003091-uvfppirt	330	32	cell	cell	NN
cord-003091-uvfppirt	330	33	responses	response	NNS
cord-003091-uvfppirt	330	34	to	to	IN
cord-003091-uvfppirt	330	35	local	local	JJ
cord-003091-uvfppirt	330	36	bacterial	bacterial	JJ
cord-003091-uvfppirt	330	37	infection	infection	NN
cord-003091-uvfppirt	330	38	Expression	expression	NN
cord-003091-uvfppirt	330	39	of	of	IN
cord-003091-uvfppirt	330	40	the	the	DT
cord-003091-uvfppirt	330	41	self	self	NN
cord-003091-uvfppirt	330	42	-	-	HYPH
cord-003091-uvfppirt	330	43	marker	marker	NN
cord-003091-uvfppirt	330	44	CD47	CD47	NNP
cord-003091-uvfppirt	330	45	on	on	IN
cord-003091-uvfppirt	330	46	dendritic	dendritic	JJ
cord-003091-uvfppirt	330	47	cells	cell	NNS
cord-003091-uvfppirt	330	48	governs	govern	VBZ
cord-003091-uvfppirt	330	49	their	-PRON-	PRP$
cord-003091-uvfppirt	330	50	trafficking	trafficking	NN
cord-003091-uvfppirt	330	51	to	to	IN
cord-003091-uvfppirt	330	52	secondary	secondary	JJ
cord-003091-uvfppirt	330	53	lymphoid	lymphoid	JJ
cord-003091-uvfppirt	330	54	organs	organ	NNS
cord-003091-uvfppirt	330	55	Tumor	tumor	NN
cord-003091-uvfppirt	330	56	immunotherapy	immunotherapy	NN
cord-003091-uvfppirt	330	57	by	by	IN
cord-003091-uvfppirt	330	58	epicutaneous	epicutaneous	NNP
cord-003091-uvfppirt	330	59	immunization	immunization	NN
cord-003091-uvfppirt	330	60	requires	require	VBZ
cord-003091-uvfppirt	330	61	Langerhans	Langerhans	NNP
cord-003091-uvfppirt	330	62	cells	cell	NNS
cord-003091-uvfppirt	330	63	Langerin	Langerin	NNP
cord-003091-uvfppirt	330	64	expressing	express	VBG
cord-003091-uvfppirt	330	65	cells	cell	NNS
cord-003091-uvfppirt	330	66	promote	promote	VBP
cord-003091-uvfppirt	330	67	skin	skin	NN
cord-003091-uvfppirt	330	68	immune	immune	JJ
cord-003091-uvfppirt	330	69	responses	response	NNS
cord-003091-uvfppirt	330	70	under	under	IN
cord-003091-uvfppirt	330	71	defined	define	VBN
cord-003091-uvfppirt	330	72	conditions	condition	NNS
cord-003091-uvfppirt	331	1	Langerin	Langerin	NNP
cord-003091-uvfppirt	331	2	+	+	CC
cord-003091-uvfppirt	331	3	dermal	dermal	JJ
cord-003091-uvfppirt	331	4	DC	DC	NNP
cord-003091-uvfppirt	331	5	,	,	,
cord-003091-uvfppirt	331	6	but	but	CC
cord-003091-uvfppirt	331	7	not	not	RB
cord-003091-uvfppirt	331	8	Langerhans	Langerhans	NNP
cord-003091-uvfppirt	331	9	cells	cell	NNS
cord-003091-uvfppirt	331	10	,	,	,
cord-003091-uvfppirt	331	11	are	be	VBP
cord-003091-uvfppirt	331	12	required	require	VBN
cord-003091-uvfppirt	331	13	for	for	IN
cord-003091-uvfppirt	331	14	effective	effective	JJ
cord-003091-uvfppirt	331	15	CD8-mediated	cd8-mediated	JJ
cord-003091-uvfppirt	331	16	immune	immune	JJ
cord-003091-uvfppirt	331	17	responses	response	NNS
cord-003091-uvfppirt	331	18	after	after	IN
cord-003091-uvfppirt	331	19	skin	skin	NN
cord-003091-uvfppirt	331	20	scarification	scarification	NN
cord-003091-uvfppirt	331	21	with	with	IN
cord-003091-uvfppirt	331	22	vaccinia	vaccinia	NN
cord-003091-uvfppirt	331	23	virus	virus	NN
cord-003091-uvfppirt	331	24	Langerhans	Langerhans	NNP
cord-003091-uvfppirt	331	25	cells	cell	NNS
cord-003091-uvfppirt	331	26	:	:	:
cord-003091-uvfppirt	331	27	not	not	RB
cord-003091-uvfppirt	331	28	your	-PRON-	PRP$
cord-003091-uvfppirt	331	29	average	average	JJ
cord-003091-uvfppirt	331	30	dendritic	dendritic	JJ
cord-003091-uvfppirt	331	31	cell	cell	NN
cord-003091-uvfppirt	331	32	Langerhans	Langerhans	NNP
cord-003091-uvfppirt	331	33	cells	cell	NNS
cord-003091-uvfppirt	331	34	suppress	suppress	VBP
cord-003091-uvfppirt	331	35	contact	contact	NN
cord-003091-uvfppirt	331	36	hypersensitivity	hypersensitivity	NN
cord-003091-uvfppirt	331	37	responses	response	NNS
cord-003091-uvfppirt	331	38	via	via	IN
cord-003091-uvfppirt	331	39	cognate	cognate	JJ
cord-003091-uvfppirt	331	40	CD4	CD4	NNP
cord-003091-uvfppirt	331	41	interaction	interaction	NN
cord-003091-uvfppirt	331	42	and	and	CC
cord-003091-uvfppirt	331	43	Langerhans	Langerhans	NNP
cord-003091-uvfppirt	331	44	cell	cell	NN
cord-003091-uvfppirt	331	45	-	-	HYPH
cord-003091-uvfppirt	331	46	derived	derive	VBN
cord-003091-uvfppirt	331	47	IL-10	IL-10	NNP
cord-003091-uvfppirt	332	1	The	the	DT
cord-003091-uvfppirt	332	2	balance	balance	NN
cord-003091-uvfppirt	332	3	between	between	IN
cord-003091-uvfppirt	332	4	immunity	immunity	NN
cord-003091-uvfppirt	332	5	and	and	CC
cord-003091-uvfppirt	332	6	tolerance	tolerance	NN
cord-003091-uvfppirt	332	7	:	:	:
cord-003091-uvfppirt	332	8	the	the	DT
cord-003091-uvfppirt	332	9	role	role	NN
cord-003091-uvfppirt	332	10	of	of	IN
cord-003091-uvfppirt	332	11	Langerhans	Langerhans	NNP
cord-003091-uvfppirt	332	12	cells	cell	NNS
cord-003091-uvfppirt	332	13	Robust	robust	JJ
cord-003091-uvfppirt	332	14	anti	anti	JJ
cord-003091-uvfppirt	332	15	-	-	JJ
cord-003091-uvfppirt	332	16	viral	viral	JJ
cord-003091-uvfppirt	332	17	immunity	immunity	NN
cord-003091-uvfppirt	332	18	requires	require	VBZ
cord-003091-uvfppirt	332	19	multiple	multiple	JJ
cord-003091-uvfppirt	332	20	distinct	distinct	JJ
cord-003091-uvfppirt	332	21	T	t	NN
cord-003091-uvfppirt	332	22	cell	cell	NN
cord-003091-uvfppirt	332	23	-	-	HYPH
cord-003091-uvfppirt	332	24	dendritic	dendritic	JJ
cord-003091-uvfppirt	332	25	cell	cell	NN
cord-003091-uvfppirt	332	26	interactions	interaction	NNS
cord-003091-uvfppirt	332	27	Migratory	migratory	JJ
cord-003091-uvfppirt	332	28	and	and	CC
cord-003091-uvfppirt	332	29	lymphoid	lymphoid	JJ
cord-003091-uvfppirt	332	30	-	-	HYPH
cord-003091-uvfppirt	332	31	resident	resident	NN
cord-003091-uvfppirt	332	32	dendritic	dendritic	JJ
cord-003091-uvfppirt	332	33	cells	cell	NNS
cord-003091-uvfppirt	332	34	cooperate	cooperate	VBP
cord-003091-uvfppirt	332	35	to	to	TO
cord-003091-uvfppirt	332	36	efficiently	efficiently	RB
cord-003091-uvfppirt	332	37	prime	prime	JJ
cord-003091-uvfppirt	332	38	naive	naive	JJ
cord-003091-uvfppirt	332	39	CD4	CD4	NNP
cord-003091-uvfppirt	332	40	T	T	NNP
cord-003091-uvfppirt	332	41	cells	cell	NNS
cord-003091-uvfppirt	332	42	Selective	selective	JJ
cord-003091-uvfppirt	332	43	and	and	CC
cord-003091-uvfppirt	332	44	site	site	NN
cord-003091-uvfppirt	332	45	-	-	HYPH
cord-003091-uvfppirt	332	46	specific	specific	JJ
cord-003091-uvfppirt	332	47	mobilization	mobilization	NN
cord-003091-uvfppirt	332	48	of	of	IN
cord-003091-uvfppirt	332	49	dermal	dermal	JJ
cord-003091-uvfppirt	332	50	dendritic	dendritic	JJ
cord-003091-uvfppirt	332	51	cells	cell	NNS
cord-003091-uvfppirt	332	52	and	and	CC
cord-003091-uvfppirt	332	53	Langerhans	Langerhans	NNP
cord-003091-uvfppirt	332	54	cells	cell	NNS
cord-003091-uvfppirt	332	55	by	by	IN
cord-003091-uvfppirt	332	56	Th1-and	th1-and	NN
cord-003091-uvfppirt	332	57	Th2-polarizing	Th2-polarizing	NNP
cord-003091-uvfppirt	332	58	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	332	59	CpG	CpG	NNP
cord-003091-uvfppirt	332	60	oligodeoxinucleotides	oligodeoxinucleotides	NNP
cord-003091-uvfppirt	332	61	and	and	CC
cord-003091-uvfppirt	332	62	flagellin	flagellin	NNP
cord-003091-uvfppirt	332	63	modulate	modulate	VB
cord-003091-uvfppirt	332	64	the	the	DT
cord-003091-uvfppirt	332	65	immune	immune	JJ
cord-003091-uvfppirt	332	66	response	response	NN
cord-003091-uvfppirt	332	67	to	to	IN
cord-003091-uvfppirt	332	68	antigens	antigen	NNS
cord-003091-uvfppirt	332	69	targeted	target	VBN
cord-003091-uvfppirt	332	70	to	to	IN
cord-003091-uvfppirt	332	71	CD8α+and	CD8α+and	NNP
cord-003091-uvfppirt	332	72	CD8α	CD8α	NNP
cord-003091-uvfppirt	332	73	-	-	HYPH
cord-003091-uvfppirt	332	74	conventional	conventional	JJ
cord-003091-uvfppirt	332	75	dendritic	dendritic	JJ
cord-003091-uvfppirt	332	76	cell	cell	NN
cord-003091-uvfppirt	332	77	subsets	subset	NNS
cord-003091-uvfppirt	332	78	CD40-targeted	cd40-targete	VBN
cord-003091-uvfppirt	332	79	dendritic	dendritic	JJ
cord-003091-uvfppirt	332	80	cell	cell	NN
cord-003091-uvfppirt	332	81	delivery	delivery	NN
cord-003091-uvfppirt	332	82	of	of	IN
cord-003091-uvfppirt	332	83	PLGA	PLGA	NNP
cord-003091-uvfppirt	332	84	-	-	HYPH
cord-003091-uvfppirt	332	85	nanoparticle	nanoparticle	NN
cord-003091-uvfppirt	332	86	vaccines	vaccine	NNS
cord-003091-uvfppirt	332	87	induce	induce	VBP
cord-003091-uvfppirt	332	88	potent	potent	JJ
cord-003091-uvfppirt	332	89	anti	anti	JJ
cord-003091-uvfppirt	332	90	-	-	JJ
cord-003091-uvfppirt	332	91	tumor	tumor	JJ
cord-003091-uvfppirt	332	92	responses	response	NNS
cord-003091-uvfppirt	332	93	Intensified	intensify	VBD
cord-003091-uvfppirt	332	94	and	and	CC
cord-003091-uvfppirt	332	95	protective	protective	JJ
cord-003091-uvfppirt	332	96	CD4	CD4	NNP
cord-003091-uvfppirt	332	97	+	+	CC
cord-003091-uvfppirt	332	98	T	t	NN
cord-003091-uvfppirt	332	99	cell	cell	NN
cord-003091-uvfppirt	332	100	immunity	immunity	NN
cord-003091-uvfppirt	332	101	in	in	IN
cord-003091-uvfppirt	332	102	mice	mouse	NNS
cord-003091-uvfppirt	332	103	with	with	IN
cord-003091-uvfppirt	332	104	anti	anti	JJ
cord-003091-uvfppirt	332	105	-	-	JJ
cord-003091-uvfppirt	332	106	dendritic	dendritic	JJ
cord-003091-uvfppirt	332	107	cell	cell	NN
cord-003091-uvfppirt	332	108	HIV	HIV	NNP
cord-003091-uvfppirt	332	109	gag	gag	NN
cord-003091-uvfppirt	332	110	fusion	fusion	NN
cord-003091-uvfppirt	332	111	antibody	antibody	NN
cord-003091-uvfppirt	332	112	vaccine	vaccine	NN
cord-003091-uvfppirt	332	113	Antigen	Antigen	NNP
cord-003091-uvfppirt	332	114	targeting	target	VBG
cord-003091-uvfppirt	332	115	to	to	IN
cord-003091-uvfppirt	332	116	dendritic	dendritic	JJ
cord-003091-uvfppirt	332	117	cells	cell	NNS
cord-003091-uvfppirt	332	118	elicits	elicit	VBZ
cord-003091-uvfppirt	332	119	long	long	RB
cord-003091-uvfppirt	332	120	-	-	HYPH
cord-003091-uvfppirt	332	121	lived	live	VBN
cord-003091-uvfppirt	332	122	T	T	NNP
cord-003091-uvfppirt	332	123	cell	cell	NN
cord-003091-uvfppirt	332	124	help	help	NN
cord-003091-uvfppirt	332	125	for	for	IN
cord-003091-uvfppirt	332	126	antibody	antibody	NN
cord-003091-uvfppirt	332	127	responses	response	NNS
cord-003091-uvfppirt	332	128	In	in	IN
cord-003091-uvfppirt	332	129	vivo	vivo	NN
cord-003091-uvfppirt	332	130	targeting	target	VBG
cord-003091-uvfppirt	332	131	of	of	IN
cord-003091-uvfppirt	332	132	antigens	antigen	NNS
cord-003091-uvfppirt	332	133	to	to	IN
cord-003091-uvfppirt	332	134	maturing	mature	VBG
cord-003091-uvfppirt	332	135	dendritic	dendritic	JJ
cord-003091-uvfppirt	332	136	cells	cell	NNS
cord-003091-uvfppirt	332	137	via	via	IN
cord-003091-uvfppirt	332	138	the	the	DT
cord-003091-uvfppirt	332	139	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	332	140	receptor	receptor	NN
cord-003091-uvfppirt	332	141	improves	improve	VBZ
cord-003091-uvfppirt	332	142	T	T	NNP
cord-003091-uvfppirt	332	143	cell	cell	NN
cord-003091-uvfppirt	332	144	vaccination	vaccination	NN
cord-003091-uvfppirt	332	145	Antibody	Antibody	NNP
cord-003091-uvfppirt	332	146	constructs	construct	VBZ
cord-003091-uvfppirt	332	147	in	in	IN
cord-003091-uvfppirt	332	148	cancer	cancer	NN
cord-003091-uvfppirt	332	149	therapy	therapy	NN
cord-003091-uvfppirt	332	150	:	:	:
cord-003091-uvfppirt	332	151	protein	protein	NN
cord-003091-uvfppirt	332	152	engineering	engineering	NN
cord-003091-uvfppirt	332	153	strategies	strategy	NNS
cord-003091-uvfppirt	332	154	to	to	TO
cord-003091-uvfppirt	332	155	improve	improve	VB
cord-003091-uvfppirt	332	156	exposure	exposure	NN
cord-003091-uvfppirt	332	157	in	in	IN
cord-003091-uvfppirt	332	158	solid	solid	JJ
cord-003091-uvfppirt	332	159	tumors	tumor	NNS
cord-003091-uvfppirt	332	160	magic	magic	JJ
cord-003091-uvfppirt	332	161	bullets	bullet	NNS
cord-003091-uvfppirt	332	162	"	"	''
cord-003091-uvfppirt	332	163	for	for	IN
cord-003091-uvfppirt	332	164	targeting	target	VBG
cord-003091-uvfppirt	332	165	the	the	DT
cord-003091-uvfppirt	332	166	immune	immune	JJ
cord-003091-uvfppirt	332	167	system	system	NN
cord-003091-uvfppirt	332	168	Drug	drug	NN
cord-003091-uvfppirt	332	169	nanocarriers	nanocarrier	NNS
cord-003091-uvfppirt	332	170	to	to	TO
cord-003091-uvfppirt	332	171	treat	treat	VB
cord-003091-uvfppirt	332	172	autoimmunity	autoimmunity	NN
cord-003091-uvfppirt	332	173	and	and	CC
cord-003091-uvfppirt	332	174	chronic	chronic	JJ
cord-003091-uvfppirt	332	175	inflammatory	inflammatory	JJ
cord-003091-uvfppirt	332	176	diseases	disease	NNS
cord-003091-uvfppirt	332	177	Nanoparticles	nanoparticle	NNS
cord-003091-uvfppirt	332	178	and	and	CC
cord-003091-uvfppirt	332	179	innate	innate	JJ
cord-003091-uvfppirt	332	180	immunity	immunity	NN
cord-003091-uvfppirt	332	181	:	:	:
cord-003091-uvfppirt	332	182	new	new	JJ
cord-003091-uvfppirt	332	183	perspectives	perspective	NNS
cord-003091-uvfppirt	332	184	on	on	IN
cord-003091-uvfppirt	332	185	host	host	NN
cord-003091-uvfppirt	332	186	defence	defence	NN
cord-003091-uvfppirt	333	1	Overall	overall	JJ
cord-003091-uvfppirt	333	2	survival	survival	NN
cord-003091-uvfppirt	333	3	analysis	analysis	NN
cord-003091-uvfppirt	333	4	of	of	IN
cord-003091-uvfppirt	333	5	a	a	DT
cord-003091-uvfppirt	333	6	phase	phase	NN
cord-003091-uvfppirt	333	7	II	ii	CD
cord-003091-uvfppirt	333	8	randomized	randomize	VBN
cord-003091-uvfppirt	333	9	controlled	control	VBN
cord-003091-uvfppirt	333	10	trial	trial	NN
cord-003091-uvfppirt	333	11	of	of	IN
cord-003091-uvfppirt	333	12	a	a	DT
cord-003091-uvfppirt	333	13	poxviral	poxviral	NN
cord-003091-uvfppirt	333	14	-	-	HYPH
cord-003091-uvfppirt	333	15	based	base	VBN
cord-003091-uvfppirt	333	16	PSA	PSA	NNP
cord-003091-uvfppirt	333	17	-	-	HYPH
cord-003091-uvfppirt	333	18	targeted	target	VBN
cord-003091-uvfppirt	333	19	immunotherapy	immunotherapy	NN
cord-003091-uvfppirt	333	20	in	in	IN
cord-003091-uvfppirt	333	21	metastatic	metastatic	JJ
cord-003091-uvfppirt	333	22	castrationresistant	castrationresistant	JJ
cord-003091-uvfppirt	333	23	prostate	prostate	NN
cord-003091-uvfppirt	333	24	cancer	cancer	NN
cord-003091-uvfppirt	334	1	A	a	DT
cord-003091-uvfppirt	334	2	novel	novel	JJ
cord-003091-uvfppirt	334	3	antigen	antigen	NN
cord-003091-uvfppirt	334	4	delivery	delivery	NN
cord-003091-uvfppirt	334	5	system	system	NN
cord-003091-uvfppirt	334	6	induces	induce	VBZ
cord-003091-uvfppirt	334	7	strong	strong	JJ
cord-003091-uvfppirt	334	8	humoral	humoral	JJ
cord-003091-uvfppirt	334	9	and	and	CC
cord-003091-uvfppirt	334	10	CTL	CTL	NNP
cord-003091-uvfppirt	334	11	immune	immune	JJ
cord-003091-uvfppirt	334	12	responses	response	NNS
cord-003091-uvfppirt	334	13	Vaccine	Vaccine	NNP
cord-003091-uvfppirt	334	14	nanocarriers	nanocarrier	NNS
cord-003091-uvfppirt	334	15	:	:	:
cord-003091-uvfppirt	334	16	coupling	couple	VBG
cord-003091-uvfppirt	334	17	intracellular	intracellular	JJ
cord-003091-uvfppirt	334	18	pathways	pathway	NNS
cord-003091-uvfppirt	334	19	and	and	CC
cord-003091-uvfppirt	334	20	cellular	cellular	JJ
cord-003091-uvfppirt	334	21	biodistribution	biodistribution	NN
cord-003091-uvfppirt	334	22	to	to	TO
cord-003091-uvfppirt	334	23	control	control	VB
cord-003091-uvfppirt	334	24	CD4	CD4	NNP
cord-003091-uvfppirt	334	25	vs	vs	IN
cord-003091-uvfppirt	334	26	CD8	CD8	NNP
cord-003091-uvfppirt	334	27	T	T	NNP
cord-003091-uvfppirt	334	28	cell	cell	NN
cord-003091-uvfppirt	334	29	responses	response	NNS
cord-003091-uvfppirt	334	30	Synthetic	synthetic	JJ
cord-003091-uvfppirt	334	31	vaccine	vaccine	NN
cord-003091-uvfppirt	334	32	nanoparticles	nanoparticle	NNS
cord-003091-uvfppirt	334	33	target	target	VBP
cord-003091-uvfppirt	334	34	to	to	IN
cord-003091-uvfppirt	334	35	lymph	lymph	NN
cord-003091-uvfppirt	334	36	node	node	NN
cord-003091-uvfppirt	334	37	triggering	trigger	VBG
cord-003091-uvfppirt	334	38	enhanced	enhance	VBN
cord-003091-uvfppirt	334	39	innate	innate	JJ
cord-003091-uvfppirt	334	40	and	and	CC
cord-003091-uvfppirt	334	41	adaptive	adaptive	JJ
cord-003091-uvfppirt	334	42	antitumor	antitumor	NN
cord-003091-uvfppirt	334	43	immunity	immunity	NN
cord-003091-uvfppirt	334	44	PLGA	PLGA	NNP
cord-003091-uvfppirt	334	45	microspheres	microsphere	NNS
cord-003091-uvfppirt	334	46	for	for	IN
cord-003091-uvfppirt	334	47	improved	improved	JJ
cord-003091-uvfppirt	334	48	antigen	antigen	NN
cord-003091-uvfppirt	334	49	delivery	delivery	NN
cord-003091-uvfppirt	334	50	to	to	IN
cord-003091-uvfppirt	334	51	dendritic	dendritic	JJ
cord-003091-uvfppirt	334	52	cells	cell	NNS
cord-003091-uvfppirt	334	53	as	as	IN
cord-003091-uvfppirt	334	54	cellular	cellular	JJ
cord-003091-uvfppirt	334	55	vaccines	vaccine	NNS
cord-003091-uvfppirt	334	56	A	a	DT
cord-003091-uvfppirt	334	57	lipid	lipid	NN
cord-003091-uvfppirt	334	58	based	base	VBN
cord-003091-uvfppirt	334	59	antigen	antigen	NN
cord-003091-uvfppirt	334	60	delivery	delivery	NN
cord-003091-uvfppirt	334	61	system	system	NN
cord-003091-uvfppirt	334	62	efficiently	efficiently	RB
cord-003091-uvfppirt	334	63	facilitates	facilitate	VBZ
cord-003091-uvfppirt	334	64	MHC	MHC	NNP
cord-003091-uvfppirt	334	65	class	class	NN
cord-003091-uvfppirt	334	66	-	-	:
cord-003091-uvfppirt	334	67	I	i	NN
cord-003091-uvfppirt	334	68	antigen	antigen	NN
cord-003091-uvfppirt	334	69	presentation	presentation	NN
cord-003091-uvfppirt	334	70	in	in	IN
cord-003091-uvfppirt	334	71	dendritic	dendritic	JJ
cord-003091-uvfppirt	334	72	cells	cell	NNS
cord-003091-uvfppirt	334	73	to	to	TO
cord-003091-uvfppirt	334	74	stimulate	stimulate	VB
cord-003091-uvfppirt	334	75	CD8+T	cd8+t	IN
cord-003091-uvfppirt	334	76	cells	cell	NNS
cord-003091-uvfppirt	334	77	Superior	superior	JJ
cord-003091-uvfppirt	334	78	antigen	antigen	NN
cord-003091-uvfppirt	334	79	cross	cross	JJ
cord-003091-uvfppirt	334	80	-	-	NN
cord-003091-uvfppirt	334	81	presentation	presentation	NN
cord-003091-uvfppirt	334	82	and	and	CC
cord-003091-uvfppirt	334	83	XCR1	XCR1	NNP
cord-003091-uvfppirt	334	84	expression	expression	NN
cord-003091-uvfppirt	334	85	define	define	VB
cord-003091-uvfppirt	334	86	human	human	JJ
cord-003091-uvfppirt	334	87	CD11c	CD11c	NNP
cord-003091-uvfppirt	335	1	+	+	CC
cord-003091-uvfppirt	336	1	CD141	CD141	NNP
cord-003091-uvfppirt	336	2	+	+	CC
cord-003091-uvfppirt	336	3	cells	cell	NNS
cord-003091-uvfppirt	336	4	as	as	IN
cord-003091-uvfppirt	336	5	homologues	homologue	NNS
cord-003091-uvfppirt	336	6	of	of	IN
cord-003091-uvfppirt	336	7	mouse	mouse	NN
cord-003091-uvfppirt	336	8	CD8	CD8	NNP
cord-003091-uvfppirt	336	9	+	+	CC
cord-003091-uvfppirt	336	10	dendritic	dendritic	JJ
cord-003091-uvfppirt	336	11	cells	cell	NNS
cord-003091-uvfppirt	337	1	CLEC9A	CLEC9A	NNP
cord-003091-uvfppirt	337	2	is	be	VBZ
cord-003091-uvfppirt	337	3	a	a	DT
cord-003091-uvfppirt	337	4	novel	novel	JJ
cord-003091-uvfppirt	337	5	activation	activation	NN
cord-003091-uvfppirt	337	6	C	c	NN
cord-003091-uvfppirt	337	7	-	-	HYPH
cord-003091-uvfppirt	337	8	type	type	NN
cord-003091-uvfppirt	337	9	lectin	lectin	NN
cord-003091-uvfppirt	337	10	-	-	HYPH
cord-003091-uvfppirt	337	11	like	like	JJ
cord-003091-uvfppirt	337	12	receptor	receptor	NN
cord-003091-uvfppirt	337	13	expressed	express	VBN
cord-003091-uvfppirt	337	14	on	on	IN
cord-003091-uvfppirt	337	15	BDCA3	bdca3	NN
cord-003091-uvfppirt	337	16	+	+	CC
cord-003091-uvfppirt	337	17	dendritic	dendritic	JJ
cord-003091-uvfppirt	337	18	cells	cell	NNS
cord-003091-uvfppirt	337	19	and	and	CC
cord-003091-uvfppirt	337	20	a	a	DT
cord-003091-uvfppirt	337	21	subset	subset	NN
cord-003091-uvfppirt	337	22	of	of	IN
cord-003091-uvfppirt	337	23	monocytes	monocyte	NNS
cord-003091-uvfppirt	337	24	Characterization	characterization	NN
cord-003091-uvfppirt	337	25	of	of	IN
cord-003091-uvfppirt	337	26	human	human	JJ
cord-003091-uvfppirt	337	27	DNGR-1	dngr-1	NN
cord-003091-uvfppirt	337	28	+	+	CC
cord-003091-uvfppirt	337	29	BDCA3	bdca3	NN
cord-003091-uvfppirt	337	30	+	+	CC
cord-003091-uvfppirt	337	31	leukocytes	leukocyte	NNS
cord-003091-uvfppirt	337	32	as	as	IN
cord-003091-uvfppirt	337	33	putative	putative	JJ
cord-003091-uvfppirt	337	34	equivalents	equivalent	NNS
cord-003091-uvfppirt	337	35	of	of	IN
cord-003091-uvfppirt	337	36	mouse	mouse	NN
cord-003091-uvfppirt	337	37	CD8α	CD8α	NNP
cord-003091-uvfppirt	337	38	+	+	CC
cord-003091-uvfppirt	337	39	dendritic	dendritic	JJ
cord-003091-uvfppirt	337	40	cells	cell	NNS
cord-003091-uvfppirt	338	1	The	the	DT
cord-003091-uvfppirt	338	2	role	role	NN
cord-003091-uvfppirt	338	3	of	of	IN
cord-003091-uvfppirt	338	4	XCR1	XCR1	NNP
cord-003091-uvfppirt	338	5	and	and	CC
cord-003091-uvfppirt	338	6	its	-PRON-	PRP$
cord-003091-uvfppirt	338	7	ligand	ligand	NN
cord-003091-uvfppirt	338	8	XCL1	XCL1	NNP
cord-003091-uvfppirt	338	9	in	in	IN
cord-003091-uvfppirt	338	10	antigen	antigen	NN
cord-003091-uvfppirt	338	11	cross	cross	JJ
cord-003091-uvfppirt	338	12	-	-	NN
cord-003091-uvfppirt	338	13	presentation	presentation	NN
cord-003091-uvfppirt	338	14	by	by	IN
cord-003091-uvfppirt	338	15	murine	murine	JJ
cord-003091-uvfppirt	338	16	and	and	CC
cord-003091-uvfppirt	338	17	human	human	JJ
cord-003091-uvfppirt	338	18	dendritic	dendritic	JJ
cord-003091-uvfppirt	338	19	cells	cell	NNS
cord-003091-uvfppirt	339	1	The	the	DT
cord-003091-uvfppirt	339	2	C	c	NN
cord-003091-uvfppirt	339	3	-	-	HYPH
cord-003091-uvfppirt	339	4	type	type	NN
cord-003091-uvfppirt	339	5	lectin	lectin	NN
cord-003091-uvfppirt	339	6	receptor	receptor	NN
cord-003091-uvfppirt	339	7	CLEC9A	CLEC9A	NNP
cord-003091-uvfppirt	339	8	mediates	mediate	VBZ
cord-003091-uvfppirt	339	9	antigen	antigen	NN
cord-003091-uvfppirt	339	10	uptake	uptake	NN
cord-003091-uvfppirt	339	11	and	and	CC
cord-003091-uvfppirt	339	12	(	(	-LRB-
cord-003091-uvfppirt	339	13	cross-	cross-	NN
cord-003091-uvfppirt	339	14	)	)	-RRB-
cord-003091-uvfppirt	339	15	presentation	presentation	NN
cord-003091-uvfppirt	339	16	by	by	IN
cord-003091-uvfppirt	339	17	human	human	JJ
cord-003091-uvfppirt	339	18	blood	blood	NN
cord-003091-uvfppirt	339	19	BDCA3	bdca3	NN
cord-003091-uvfppirt	339	20	+	+	CC
cord-003091-uvfppirt	339	21	myeloid	myeloid	JJ
cord-003091-uvfppirt	339	22	dendritic	dendritic	JJ
cord-003091-uvfppirt	339	23	cells	cell	NNS
cord-003091-uvfppirt	340	1	Antibodies	antibody	NNS
cord-003091-uvfppirt	340	2	targeting	target	VBG
cord-003091-uvfppirt	340	3	Clec9A	Clec9A	NNP
cord-003091-uvfppirt	340	4	promote	promote	VBP
cord-003091-uvfppirt	340	5	strong	strong	JJ
cord-003091-uvfppirt	340	6	humoral	humoral	JJ
cord-003091-uvfppirt	340	7	immunity	immunity	NN
cord-003091-uvfppirt	340	8	without	without	IN
cord-003091-uvfppirt	340	9	adjuvant	adjuvant	NN
cord-003091-uvfppirt	340	10	in	in	IN
cord-003091-uvfppirt	340	11	mice	mouse	NNS
cord-003091-uvfppirt	340	12	and	and	CC
cord-003091-uvfppirt	340	13	non	non	JJ
cord-003091-uvfppirt	340	14	-	-	JJ
cord-003091-uvfppirt	340	15	human	human	JJ
cord-003091-uvfppirt	340	16	primates	primate	NNS
cord-003091-uvfppirt	341	1	The	the	DT
cord-003091-uvfppirt	341	2	dendritic	dendritic	JJ
cord-003091-uvfppirt	341	3	cell	cell	NN
cord-003091-uvfppirt	341	4	subtype	subtype	NN
cord-003091-uvfppirt	341	5	restricted	restrict	VBN
cord-003091-uvfppirt	342	1	C	c	NN
cord-003091-uvfppirt	342	2	-	-	HYPH
cord-003091-uvfppirt	342	3	type	type	NN
cord-003091-uvfppirt	342	4	lectin	lectin	NN
cord-003091-uvfppirt	342	5	Clec9A	Clec9A	NNP
cord-003091-uvfppirt	342	6	is	be	VBZ
cord-003091-uvfppirt	342	7	a	a	DT
cord-003091-uvfppirt	342	8	target	target	NN
cord-003091-uvfppirt	342	9	for	for	IN
cord-003091-uvfppirt	342	10	vaccine	vaccine	NN
cord-003091-uvfppirt	342	11	enhancement	enhancement	NN
cord-003091-uvfppirt	343	1	Targeting	target	VBG
cord-003091-uvfppirt	343	2	antigen	antigen	NN
cord-003091-uvfppirt	343	3	to	to	IN
cord-003091-uvfppirt	343	4	mouse	mouse	NN
cord-003091-uvfppirt	343	5	dendritic	dendritic	JJ
cord-003091-uvfppirt	343	6	cells	cell	NNS
cord-003091-uvfppirt	343	7	via	via	IN
cord-003091-uvfppirt	343	8	Clec9A	Clec9A	NNP
cord-003091-uvfppirt	343	9	induces	induce	VBZ
cord-003091-uvfppirt	343	10	potent	potent	JJ
cord-003091-uvfppirt	343	11	CD4	CD4	NNP
cord-003091-uvfppirt	343	12	T	T	NNP
cord-003091-uvfppirt	343	13	cell	cell	NN
cord-003091-uvfppirt	343	14	responses	response	NNS
cord-003091-uvfppirt	343	15	biased	bias	VBN
cord-003091-uvfppirt	343	16	toward	toward	IN
cord-003091-uvfppirt	343	17	a	a	DT
cord-003091-uvfppirt	343	18	follicular	follicular	JJ
cord-003091-uvfppirt	343	19	helper	helper	NN
cord-003091-uvfppirt	343	20	phenotype	phenotype	NN
cord-003091-uvfppirt	343	21	Targeting	target	VBG
cord-003091-uvfppirt	343	22	antigen	antigen	NN
cord-003091-uvfppirt	343	23	to	to	IN
cord-003091-uvfppirt	343	24	Clec9A	Clec9A	NNP
cord-003091-uvfppirt	343	25	primes	prime	NNS
cord-003091-uvfppirt	343	26	follicular	follicular	JJ
cord-003091-uvfppirt	343	27	Th	Th	NNP
cord-003091-uvfppirt	343	28	cell	cell	NN
cord-003091-uvfppirt	343	29	memory	memory	NN
cord-003091-uvfppirt	343	30	responses	response	NNS
cord-003091-uvfppirt	343	31	capable	capable	JJ
cord-003091-uvfppirt	343	32	of	of	IN
cord-003091-uvfppirt	343	33	robust	robust	JJ
cord-003091-uvfppirt	343	34	recall	recall	NN
cord-003091-uvfppirt	344	1	Evolution	evolution	NN
cord-003091-uvfppirt	344	2	of	of	IN
cord-003091-uvfppirt	344	3	B	b	NN
cord-003091-uvfppirt	344	4	cell	cell	NN
cord-003091-uvfppirt	344	5	responses	response	NNS
cord-003091-uvfppirt	344	6	to	to	IN
cord-003091-uvfppirt	345	1	Clec9A	Clec9A	NNP
cord-003091-uvfppirt	345	2	-	-	HYPH
cord-003091-uvfppirt	345	3	targeted	target	VBN
cord-003091-uvfppirt	345	4	antigen	antigen	NN
cord-003091-uvfppirt	345	5	Targeting	target	VBG
cord-003091-uvfppirt	345	6	CLEC9A	CLEC9A	NNP
cord-003091-uvfppirt	345	7	delivers	deliver	VBZ
cord-003091-uvfppirt	345	8	antigen	antigen	NN
cord-003091-uvfppirt	345	9	to	to	IN
cord-003091-uvfppirt	345	10	human	human	JJ
cord-003091-uvfppirt	345	11	CD141	CD141	NNP
cord-003091-uvfppirt	345	12	+	+	CC
cord-003091-uvfppirt	345	13	DC	DC	NNP
cord-003091-uvfppirt	345	14	for	for	IN
cord-003091-uvfppirt	345	15	CD4	CD4	NNP
cord-003091-uvfppirt	345	16	+	+	CC
cord-003091-uvfppirt	345	17	and	and	CC
cord-003091-uvfppirt	345	18	CD8+T	cd8+t	JJ
cord-003091-uvfppirt	345	19	cell	cell	NN
cord-003091-uvfppirt	345	20	recognition	recognition	NN
cord-003091-uvfppirt	345	21	Enhancing	enhance	VBG
cord-003091-uvfppirt	345	22	vaccine	vaccine	NN
cord-003091-uvfppirt	345	23	antibody	antibody	NN
cord-003091-uvfppirt	345	24	responses	response	NNS
cord-003091-uvfppirt	345	25	by	by	IN
cord-003091-uvfppirt	345	26	targeting	target	VBG
cord-003091-uvfppirt	345	27	Clec9A	Clec9A	NNP
cord-003091-uvfppirt	345	28	on	on	IN
cord-003091-uvfppirt	345	29	dendritic	dendritic	JJ
cord-003091-uvfppirt	345	30	cells	cell	NNS
cord-003091-uvfppirt	345	31	Tumor	tumor	NN
cord-003091-uvfppirt	345	32	therapy	therapy	NN
cord-003091-uvfppirt	345	33	in	in	IN
cord-003091-uvfppirt	345	34	mice	mouse	NNS
cord-003091-uvfppirt	345	35	via	via	IN
cord-003091-uvfppirt	345	36	antigen	antigen	NN
cord-003091-uvfppirt	345	37	targeting	target	VBG
cord-003091-uvfppirt	345	38	to	to	IN
cord-003091-uvfppirt	345	39	a	a	DT
cord-003091-uvfppirt	345	40	novel	novel	NN
cord-003091-uvfppirt	345	41	,	,	,
cord-003091-uvfppirt	345	42	DC	DC	NNP
cord-003091-uvfppirt	345	43	-	-	HYPH
cord-003091-uvfppirt	345	44	restricted	restrict	VBN
cord-003091-uvfppirt	345	45	C	c	NN
cord-003091-uvfppirt	345	46	-	-	HYPH
cord-003091-uvfppirt	345	47	type	type	NN
cord-003091-uvfppirt	345	48	lectin	lectin	NN
cord-003091-uvfppirt	346	1	The	the	DT
cord-003091-uvfppirt	346	2	receptor	receptor	NN
cord-003091-uvfppirt	346	3	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	346	4	expressed	express	VBN
cord-003091-uvfppirt	346	5	by	by	IN
cord-003091-uvfppirt	346	6	dendritic	dendritic	JJ
cord-003091-uvfppirt	346	7	cells	cell	NNS
cord-003091-uvfppirt	346	8	and	and	CC
cord-003091-uvfppirt	346	9	thymic	thymic	JJ
cord-003091-uvfppirt	346	10	epithelial	epithelial	JJ
cord-003091-uvfppirt	346	11	cells	cell	NNS
cord-003091-uvfppirt	346	12	is	be	VBZ
cord-003091-uvfppirt	346	13	involved	involve	VBN
cord-003091-uvfppirt	346	14	in	in	IN
cord-003091-uvfppirt	346	15	antigen	antigen	NN
cord-003091-uvfppirt	346	16	processing	processing	NN
cord-003091-uvfppirt	346	17	CD205	cd205	NN
cord-003091-uvfppirt	346	18	(	(	-LRB-
cord-003091-uvfppirt	346	19	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	346	20	)	)	-RRB-
cord-003091-uvfppirt	346	21	:	:	:
cord-003091-uvfppirt	346	22	a	a	DT
cord-003091-uvfppirt	346	23	recognition	recognition	NN
cord-003091-uvfppirt	346	24	receptor	receptor	NN
cord-003091-uvfppirt	346	25	for	for	IN
cord-003091-uvfppirt	346	26	apoptotic	apoptotic	JJ
cord-003091-uvfppirt	346	27	and	and	CC
cord-003091-uvfppirt	346	28	necrotic	necrotic	JJ
cord-003091-uvfppirt	346	29	self	self	NN
cord-003091-uvfppirt	346	30	Expression	expression	NN
cord-003091-uvfppirt	346	31	of	of	IN
cord-003091-uvfppirt	346	32	human	human	NN
cord-003091-uvfppirt	347	1	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	347	2	(	(	-LRB-
cord-003091-uvfppirt	347	3	CD205	cd205	RB
cord-003091-uvfppirt	347	4	)	)	-RRB-
cord-003091-uvfppirt	347	5	multilectin	multilectin	NNP
cord-003091-uvfppirt	347	6	receptor	receptor	NN
cord-003091-uvfppirt	347	7	on	on	IN
cord-003091-uvfppirt	347	8	leukocytes	leukocyte	NNS
cord-003091-uvfppirt	348	1	The	the	DT
cord-003091-uvfppirt	348	2	dendritic	dendritic	JJ
cord-003091-uvfppirt	348	3	cell	cell	NN
cord-003091-uvfppirt	348	4	receptor	receptor	NN
cord-003091-uvfppirt	348	5	for	for	IN
cord-003091-uvfppirt	348	6	endocytosis	endocytosis	NN
cord-003091-uvfppirt	348	7	,	,	,
cord-003091-uvfppirt	348	8	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	348	9	,	,	,
cord-003091-uvfppirt	348	10	can	can	MD
cord-003091-uvfppirt	348	11	recycle	recycle	VB
cord-003091-uvfppirt	348	12	and	and	CC
cord-003091-uvfppirt	348	13	enhance	enhance	VB
cord-003091-uvfppirt	348	14	antigen	antigen	NN
cord-003091-uvfppirt	348	15	presentation	presentation	NN
cord-003091-uvfppirt	348	16	via	via	IN
cord-003091-uvfppirt	348	17	major	major	JJ
cord-003091-uvfppirt	348	18	histocompatibility	histocompatibility	NN
cord-003091-uvfppirt	348	19	complex	complex	JJ
cord-003091-uvfppirt	348	20	class	class	NN
cord-003091-uvfppirt	348	21	II	ii	NN
cord-003091-uvfppirt	348	22	-positive	-positive	JJ
cord-003091-uvfppirt	348	23	lysosomal	lysosomal	JJ
cord-003091-uvfppirt	348	24	compartments	compartment	NNS
cord-003091-uvfppirt	349	1	A	a	DT
cord-003091-uvfppirt	349	2	monoclonal	monoclonal	JJ
cord-003091-uvfppirt	349	3	antibody	antibody	NN
cord-003091-uvfppirt	349	4	to	to	IN
cord-003091-uvfppirt	349	5	the	the	DT
cord-003091-uvfppirt	349	6	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	349	7	endocytosis	endocytosis	NN
cord-003091-uvfppirt	349	8	receptor	receptor	NN
cord-003091-uvfppirt	349	9	on	on	IN
cord-003091-uvfppirt	349	10	human	human	JJ
cord-003091-uvfppirt	349	11	dendritic	dendritic	JJ
cord-003091-uvfppirt	349	12	cells	cell	NNS
cord-003091-uvfppirt	349	13	Efficient	efficient	JJ
cord-003091-uvfppirt	349	14	targeting	targeting	NN
cord-003091-uvfppirt	349	15	of	of	IN
cord-003091-uvfppirt	349	16	protein	protein	NN
cord-003091-uvfppirt	349	17	antigen	antigen	NN
cord-003091-uvfppirt	349	18	to	to	IN
cord-003091-uvfppirt	349	19	the	the	DT
cord-003091-uvfppirt	349	20	dendritic	dendritic	JJ
cord-003091-uvfppirt	349	21	cell	cell	NN
cord-003091-uvfppirt	349	22	receptor	receptor	NN
cord-003091-uvfppirt	349	23	Frontiers	Frontiers	NNPS
cord-003091-uvfppirt	349	24	in	in	IN
cord-003091-uvfppirt	349	25	Immunology	Immunology	NNP
cord-003091-uvfppirt	349	26	|	|	NNP
cord-003091-uvfppirt	349	27	www.frontiersin.org	www.frontiersin.org	NN
cord-003091-uvfppirt	349	28	in	in	IN
cord-003091-uvfppirt	349	29	the	the	DT
cord-003091-uvfppirt	349	30	steady	steady	JJ
cord-003091-uvfppirt	349	31	state	state	NN
cord-003091-uvfppirt	349	32	leads	lead	VBZ
cord-003091-uvfppirt	349	33	to	to	IN
cord-003091-uvfppirt	349	34	antigen	antigen	NN
cord-003091-uvfppirt	349	35	presentation	presentation	NN
cord-003091-uvfppirt	349	36	on	on	IN
cord-003091-uvfppirt	349	37	major	major	JJ
cord-003091-uvfppirt	349	38	histocompatibility	histocompatibility	NN
cord-003091-uvfppirt	349	39	complex	complex	JJ
cord-003091-uvfppirt	349	40	class	class	NN
cord-003091-uvfppirt	349	41	I	-PRON-	PRP
cord-003091-uvfppirt	349	42	products	product	NNS
cord-003091-uvfppirt	349	43	and	and	CC
cord-003091-uvfppirt	349	44	peripheral	peripheral	JJ
cord-003091-uvfppirt	349	45	CD8	CD8	NNP
cord-003091-uvfppirt	349	46	+	+	CC
cord-003091-uvfppirt	349	47	T	T	NNP
cord-003091-uvfppirt	349	48	cell	cell	NN
cord-003091-uvfppirt	349	49	tolerance	tolerance	NN
cord-003091-uvfppirt	349	50	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	350	1	mediates	mediate	VBZ
cord-003091-uvfppirt	350	2	antigen	antigen	NN
cord-003091-uvfppirt	350	3	uptake	uptake	NN
cord-003091-uvfppirt	350	4	and	and	CC
cord-003091-uvfppirt	350	5	presentation	presentation	NN
cord-003091-uvfppirt	350	6	by	by	IN
cord-003091-uvfppirt	350	7	both	both	DT
cord-003091-uvfppirt	350	8	resting	rest	VBG
cord-003091-uvfppirt	350	9	and	and	CC
cord-003091-uvfppirt	350	10	activated	activate	VBN
cord-003091-uvfppirt	350	11	human	human	JJ
cord-003091-uvfppirt	350	12	plasmacytoid	plasmacytoid	NN
cord-003091-uvfppirt	350	13	dendritic	dendritic	JJ
cord-003091-uvfppirt	350	14	cells	cell	NNS
cord-003091-uvfppirt	350	15	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	350	16	receptor	receptor	NN
cord-003091-uvfppirt	350	17	on	on	IN
cord-003091-uvfppirt	350	18	dendritic	dendritic	JJ
cord-003091-uvfppirt	350	19	cells	cell	NNS
cord-003091-uvfppirt	351	1	mediates	mediate	VBZ
cord-003091-uvfppirt	351	2	presentation	presentation	NN
cord-003091-uvfppirt	351	3	of	of	IN
cord-003091-uvfppirt	351	4	HIV	HIV	NNP
cord-003091-uvfppirt	351	5	gag	gag	NN
cord-003091-uvfppirt	351	6	protein	protein	NN
cord-003091-uvfppirt	351	7	to	to	IN
cord-003091-uvfppirt	351	8	CD8	CD8	NNP
cord-003091-uvfppirt	351	9	+	+	CC
cord-003091-uvfppirt	351	10	T	T	NNP
cord-003091-uvfppirt	351	11	cells	cell	NNS
cord-003091-uvfppirt	351	12	in	in	IN
cord-003091-uvfppirt	351	13	a	a	DT
cord-003091-uvfppirt	351	14	spectrum	spectrum	NN
cord-003091-uvfppirt	351	15	of	of	IN
cord-003091-uvfppirt	351	16	human	human	JJ
cord-003091-uvfppirt	351	17	MHC	MHC	NNP
cord-003091-uvfppirt	351	18	I	-PRON-	PRP
cord-003091-uvfppirt	351	19	haplotypes	haplotype	VBZ
cord-003091-uvfppirt	351	20	Antigen	Antigen	NNP
cord-003091-uvfppirt	351	21	delivery	delivery	NN
cord-003091-uvfppirt	351	22	by	by	IN
cord-003091-uvfppirt	351	23	filamentous	filamentous	JJ
cord-003091-uvfppirt	351	24	bacteriophage	bacteriophage	NN
cord-003091-uvfppirt	351	25	fd	fd	NNP
cord-003091-uvfppirt	351	26	displaying	display	VBG
cord-003091-uvfppirt	351	27	an	an	DT
cord-003091-uvfppirt	351	28	anti	anti	JJ
cord-003091-uvfppirt	351	29	-	-	JJ
cord-003091-uvfppirt	351	30	DEC-205	dec-205	JJ
cord-003091-uvfppirt	351	31	single	single	JJ
cord-003091-uvfppirt	351	32	-	-	HYPH
cord-003091-uvfppirt	351	33	chain	chain	NN
cord-003091-uvfppirt	351	34	variable	variable	JJ
cord-003091-uvfppirt	351	35	fragment	fragment	NN
cord-003091-uvfppirt	351	36	confers	confer	VBZ
cord-003091-uvfppirt	351	37	adjuvanticity	adjuvanticity	NN
cord-003091-uvfppirt	351	38	by	by	IN
cord-003091-uvfppirt	351	39	triggering	trigger	VBG
cord-003091-uvfppirt	351	40	a	a	DT
cord-003091-uvfppirt	351	41	TLR9-mediated	tlr9-mediate	VBN
cord-003091-uvfppirt	351	42	immune	immune	JJ
cord-003091-uvfppirt	351	43	response	response	NN
cord-003091-uvfppirt	351	44	Vaccination	vaccination	NN
cord-003091-uvfppirt	351	45	with	with	IN
cord-003091-uvfppirt	351	46	filamentous	filamentous	JJ
cord-003091-uvfppirt	351	47	bacteriophages	bacteriophage	NNS
cord-003091-uvfppirt	351	48	targeting	target	VBG
cord-003091-uvfppirt	351	49	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	351	50	induces	induce	VBZ
cord-003091-uvfppirt	351	51	DC	DC	NNP
cord-003091-uvfppirt	351	52	maturation	maturation	NN
cord-003091-uvfppirt	351	53	and	and	CC
cord-003091-uvfppirt	351	54	potent	potent	JJ
cord-003091-uvfppirt	351	55	anti	anti	JJ
cord-003091-uvfppirt	351	56	-	-	JJ
cord-003091-uvfppirt	351	57	tumor	tumor	JJ
cord-003091-uvfppirt	351	58	T	t	NN
cord-003091-uvfppirt	351	59	-	-	HYPH
cord-003091-uvfppirt	351	60	cell	cell	NN
cord-003091-uvfppirt	351	61	responses	response	NNS
cord-003091-uvfppirt	351	62	in	in	IN
cord-003091-uvfppirt	351	63	the	the	DT
cord-003091-uvfppirt	351	64	absence	absence	NN
cord-003091-uvfppirt	351	65	of	of	IN
cord-003091-uvfppirt	351	66	adjuvants	adjuvant	NNS
cord-003091-uvfppirt	351	67	DEC-205	DEC-205	NNP
cord-003091-uvfppirt	351	68	is	be	VBZ
cord-003091-uvfppirt	351	69	a	a	DT
cord-003091-uvfppirt	351	70	cell	cell	NN
cord-003091-uvfppirt	351	71	surface	surface	NN
cord-003091-uvfppirt	351	72	receptor	receptor	NN
cord-003091-uvfppirt	351	73	for	for	IN
cord-003091-uvfppirt	351	74	CpG	CpG	NNP
cord-003091-uvfppirt	351	75	oligonucleotides	oligonucleotides	NNP
cord-003091-uvfppirt	351	76	CD40	CD40	NNP
cord-003091-uvfppirt	351	77	,	,	,
cord-003091-uvfppirt	351	78	an	an	DT
cord-003091-uvfppirt	351	79	extracellular	extracellular	JJ
cord-003091-uvfppirt	351	80	receptor	receptor	NN
cord-003091-uvfppirt	351	81	for	for	IN
cord-003091-uvfppirt	351	82	binding	binding	NN
cord-003091-uvfppirt	351	83	and	and	CC
cord-003091-uvfppirt	351	84	uptake	uptake	NN
cord-003091-uvfppirt	351	85	of	of	IN
cord-003091-uvfppirt	351	86	Hsp70-peptide	hsp70-peptide	NN
cord-003091-uvfppirt	351	87	complexes	complex	NNS
cord-003091-uvfppirt	351	88	Delivery	delivery	NN
cord-003091-uvfppirt	351	89	of	of	IN
cord-003091-uvfppirt	351	90	antigen	antigen	NN
cord-003091-uvfppirt	351	91	to	to	IN
cord-003091-uvfppirt	351	92	CD40	CD40	NNP
cord-003091-uvfppirt	351	93	induces	induce	VBZ
cord-003091-uvfppirt	351	94	protective	protective	JJ
cord-003091-uvfppirt	351	95	immune	immune	JJ
cord-003091-uvfppirt	351	96	responses	response	NNS
cord-003091-uvfppirt	351	97	against	against	IN
cord-003091-uvfppirt	351	98	tumors	tumor	NNS
cord-003091-uvfppirt	351	99	CD40-expressing	cd40-expresse	VBG
cord-003091-uvfppirt	351	100	plasmid	plasmid	NN
cord-003091-uvfppirt	352	1	induces	induce	VBZ
cord-003091-uvfppirt	352	2	anti	anti	JJ
cord-003091-uvfppirt	352	3	-	-	JJ
cord-003091-uvfppirt	352	4	CD40	cd40	JJ
cord-003091-uvfppirt	352	5	antibody	antibody	NN
cord-003091-uvfppirt	352	6	and	and	CC
cord-003091-uvfppirt	352	7	enhances	enhance	VBZ
cord-003091-uvfppirt	352	8	immune	immune	JJ
cord-003091-uvfppirt	352	9	responses	response	NNS
cord-003091-uvfppirt	352	10	to	to	IN
cord-003091-uvfppirt	352	11	DNA	dna	NN
cord-003091-uvfppirt	352	12	vaccination	vaccination	NN
cord-003091-uvfppirt	353	1	A	a	DT
cord-003091-uvfppirt	353	2	novel	novel	JJ
cord-003091-uvfppirt	353	3	vaccine	vaccine	NN
cord-003091-uvfppirt	353	4	for	for	IN
cord-003091-uvfppirt	353	5	mantle	mantle	NN
cord-003091-uvfppirt	353	6	cell	cell	NN
cord-003091-uvfppirt	353	7	lymphoma	lymphoma	NN
cord-003091-uvfppirt	353	8	based	base	VBN
cord-003091-uvfppirt	353	9	on	on	IN
cord-003091-uvfppirt	353	10	targeting	target	VBG
cord-003091-uvfppirt	353	11	cyclin	cyclin	NN
cord-003091-uvfppirt	353	12	D1	d1	NN
cord-003091-uvfppirt	353	13	to	to	IN
cord-003091-uvfppirt	353	14	dendritic	dendritic	JJ
cord-003091-uvfppirt	353	15	cells	cell	NNS
cord-003091-uvfppirt	353	16	via	via	IN
cord-003091-uvfppirt	353	17	CD40	CD40	NNP
cord-003091-uvfppirt	353	18	hematology	hematology	NNP
cord-003091-uvfppirt	353	19	&	&	CC
cord-003091-uvfppirt	353	20	oncology	oncology	NN
cord-003091-uvfppirt	353	21	Prolonged	prolong	VBN
cord-003091-uvfppirt	353	22	contact	contact	NN
cord-003091-uvfppirt	353	23	with	with	IN
cord-003091-uvfppirt	353	24	dendritic	dendritic	JJ
cord-003091-uvfppirt	353	25	cells	cell	NNS
cord-003091-uvfppirt	353	26	turns	turn	VBZ
cord-003091-uvfppirt	353	27	lymph	lymph	NN
cord-003091-uvfppirt	353	28	node	node	NN
cord-003091-uvfppirt	353	29	-	-	HYPH
cord-003091-uvfppirt	353	30	resident	resident	NN
cord-003091-uvfppirt	353	31	NK	NK	NNP
cord-003091-uvfppirt	353	32	cells	cell	NNS
cord-003091-uvfppirt	353	33	into	into	IN
cord-003091-uvfppirt	353	34	anti	anti	JJ
cord-003091-uvfppirt	353	35	-	-	JJ
cord-003091-uvfppirt	353	36	tumor	tumor	JJ
cord-003091-uvfppirt	353	37	effectors	effector	NNS
cord-003091-uvfppirt	353	38	Peptide	peptide	NN
cord-003091-uvfppirt	353	39	-	-	HYPH
cord-003091-uvfppirt	353	40	pulsed	pulse	VBN
cord-003091-uvfppirt	353	41	dendritic	dendritic	JJ
cord-003091-uvfppirt	353	42	cells	cell	NNS
cord-003091-uvfppirt	353	43	have	have	VBP
cord-003091-uvfppirt	353	44	superior	superior	JJ
cord-003091-uvfppirt	353	45	ability	ability	NN
cord-003091-uvfppirt	353	46	to	to	TO
cord-003091-uvfppirt	353	47	induce	induce	VB
cord-003091-uvfppirt	353	48	immune	immune	NN
cord-003091-uvfppirt	353	49	-	-	HYPH
cord-003091-uvfppirt	353	50	mediated	mediate	VBN
cord-003091-uvfppirt	353	51	tissue	tissue	NN
cord-003091-uvfppirt	353	52	destruction	destruction	NN
cord-003091-uvfppirt	353	53	compared	compare	VBN
cord-003091-uvfppirt	353	54	to	to	IN
cord-003091-uvfppirt	353	55	peptide	peptide	NN
cord-003091-uvfppirt	353	56	with	with	IN
cord-003091-uvfppirt	353	57	adjuvant	adjuvant	JJ
cord-003091-uvfppirt	353	58	Superior	Superior	NNP
cord-003091-uvfppirt	353	59	induction	induction	NN
cord-003091-uvfppirt	353	60	of	of	IN
cord-003091-uvfppirt	353	61	anti	anti	JJ
cord-003091-uvfppirt	353	62	-	-	JJ
cord-003091-uvfppirt	353	63	tumor	tumor	JJ
cord-003091-uvfppirt	353	64	CTL	ctl	NN
cord-003091-uvfppirt	353	65	immunity	immunity	NN
cord-003091-uvfppirt	353	66	by	by	IN
cord-003091-uvfppirt	353	67	extended	extended	JJ
cord-003091-uvfppirt	353	68	peptide	peptide	NN
cord-003091-uvfppirt	353	69	vaccines	vaccine	NNS
cord-003091-uvfppirt	353	70	involves	involve	VBZ
cord-003091-uvfppirt	353	71	prolonged	prolong	VBN
cord-003091-uvfppirt	353	72	,	,	,
cord-003091-uvfppirt	353	73	DC	DC	NNP
cord-003091-uvfppirt	353	74	-	-	HYPH
cord-003091-uvfppirt	353	75	focused	focus	VBN
cord-003091-uvfppirt	353	76	antigen	antigen	NN
cord-003091-uvfppirt	353	77	presentation	presentation	NN
cord-003091-uvfppirt	353	78	Dendritic	dendritic	JJ
cord-003091-uvfppirt	353	79	cells	cell	NNS
cord-003091-uvfppirt	353	80	process	process	VBP
cord-003091-uvfppirt	353	81	synthetic	synthetic	JJ
cord-003091-uvfppirt	353	82	long	long	JJ
cord-003091-uvfppirt	353	83	peptides	peptide	NNS
cord-003091-uvfppirt	353	84	better	well	JJR
cord-003091-uvfppirt	353	85	than	than	IN
cord-003091-uvfppirt	353	86	whole	whole	JJ
cord-003091-uvfppirt	353	87	protein	protein	NN
cord-003091-uvfppirt	353	88	,	,	,
cord-003091-uvfppirt	353	89	improving	improve	VBG
cord-003091-uvfppirt	353	90	antigen	antigen	NN
cord-003091-uvfppirt	353	91	presentation	presentation	NN
cord-003091-uvfppirt	353	92	and	and	CC
cord-003091-uvfppirt	353	93	T	t	NN
cord-003091-uvfppirt	353	94	-	-	HYPH
cord-003091-uvfppirt	353	95	cell	cell	NN
cord-003091-uvfppirt	353	96	activation	activation	NN
cord-003091-uvfppirt	353	97	Vaccination	vaccination	NN
cord-003091-uvfppirt	353	98	against	against	IN
cord-003091-uvfppirt	353	99	HPV-16	HPV-16	NNP
cord-003091-uvfppirt	353	100	oncoproteins	oncoprotein	NNS
cord-003091-uvfppirt	353	101	for	for	IN
cord-003091-uvfppirt	353	102	vulvar	vulvar	NN
cord-003091-uvfppirt	353	103	intraepithelial	intraepithelial	JJ
cord-003091-uvfppirt	354	1	neoplasia	neoplasia	NNP
cord-003091-uvfppirt	354	2	Phase	phase	NN
cord-003091-uvfppirt	355	1	I	-PRON-	PRP
cord-003091-uvfppirt	355	2	trial	trial	NN
cord-003091-uvfppirt	355	3	of	of	IN
cord-003091-uvfppirt	355	4	overlapping	overlap	VBG
cord-003091-uvfppirt	355	5	long	long	JJ
cord-003091-uvfppirt	355	6	peptides	peptide	NNS
cord-003091-uvfppirt	355	7	from	from	IN
cord-003091-uvfppirt	355	8	a	a	DT
cord-003091-uvfppirt	355	9	tumor	tumor	NN
cord-003091-uvfppirt	355	10	self	self	NN
cord-003091-uvfppirt	355	11	-	-	HYPH
cord-003091-uvfppirt	355	12	antigen	antigen	NN
cord-003091-uvfppirt	355	13	and	and	CC
cord-003091-uvfppirt	355	14	poly	poly	JJ
cord-003091-uvfppirt	355	15	-	-	HYPH
cord-003091-uvfppirt	355	16	ICLC	ICLC	NNP
cord-003091-uvfppirt	355	17	shows	show	VBZ
cord-003091-uvfppirt	355	18	rapid	rapid	JJ
cord-003091-uvfppirt	355	19	induction	induction	NN
cord-003091-uvfppirt	355	20	of	of	IN
cord-003091-uvfppirt	355	21	integrated	integrated	JJ
cord-003091-uvfppirt	355	22	immune	immune	JJ
cord-003091-uvfppirt	355	23	response	response	NN
cord-003091-uvfppirt	355	24	in	in	IN
cord-003091-uvfppirt	355	25	ovarian	ovarian	JJ
cord-003091-uvfppirt	355	26	cancer	cancer	NN
cord-003091-uvfppirt	355	27	patients	patient	NNS
cord-003091-uvfppirt	355	28	Addition	Addition	NNP
cord-003091-uvfppirt	355	29	of	of	IN
cord-003091-uvfppirt	355	30	interferon	interferon	NN
cord-003091-uvfppirt	355	31	-	-	HYPH
cord-003091-uvfppirt	355	32	α	α	NN
cord-003091-uvfppirt	355	33	to	to	IN
cord-003091-uvfppirt	355	34	the	the	DT
cord-003091-uvfppirt	355	35	p53-SLP	p53-SLP	NNP
cord-003091-uvfppirt	355	36	V	V	NNP
cord-003091-uvfppirt	355	37	vaccine	vaccine	NN
cord-003091-uvfppirt	355	38	results	result	NNS
cord-003091-uvfppirt	355	39	in	in	IN
cord-003091-uvfppirt	355	40	increased	increase	VBN
cord-003091-uvfppirt	355	41	production	production	NN
cord-003091-uvfppirt	355	42	of	of	IN
cord-003091-uvfppirt	355	43	interferon	interferon	NN
cord-003091-uvfppirt	355	44	-	-	HYPH
cord-003091-uvfppirt	355	45	c	c	NN
cord-003091-uvfppirt	355	46	in	in	IN
cord-003091-uvfppirt	355	47	vaccinated	vaccinated	JJ
cord-003091-uvfppirt	355	48	colorectal	colorectal	JJ
cord-003091-uvfppirt	355	49	cancer	cancer	NN
cord-003091-uvfppirt	355	50	patients	patient	NNS
cord-003091-uvfppirt	355	51	:	:	:
cord-003091-uvfppirt	355	52	a	a	DT
cord-003091-uvfppirt	355	53	phase	phase	NN
cord-003091-uvfppirt	355	54	I	-PRON-	PRP
cord-003091-uvfppirt	355	55	/	/	SYM
cord-003091-uvfppirt	355	56	II	II	NNP
cord-003091-uvfppirt	355	57	clinical	clinical	JJ
cord-003091-uvfppirt	355	58	trial	trial	NN
cord-003091-uvfppirt	355	59	Induction	Induction	NNP
cord-003091-uvfppirt	355	60	of	of	IN
cord-003091-uvfppirt	355	61	p53-specific	p53-specific	CD
cord-003091-uvfppirt	355	62	immunity	immunity	NN
cord-003091-uvfppirt	355	63	by	by	IN
cord-003091-uvfppirt	355	64	a	a	DT
cord-003091-uvfppirt	355	65	p53	p53	NN
cord-003091-uvfppirt	355	66	synthetic	synthetic	JJ
cord-003091-uvfppirt	355	67	long	long	JJ
cord-003091-uvfppirt	355	68	peptide	peptide	JJ
cord-003091-uvfppirt	355	69	vaccine	vaccine	NN
cord-003091-uvfppirt	355	70	in	in	IN
cord-003091-uvfppirt	355	71	patients	patient	NNS
cord-003091-uvfppirt	355	72	T	T	NNP
cord-003091-uvfppirt	355	73	reated	reate	VBN
cord-003091-uvfppirt	355	74	for	for	IN
cord-003091-uvfppirt	355	75	metastatic	metastatic	JJ
cord-003091-uvfppirt	355	76	colorectal	colorectal	JJ
cord-003091-uvfppirt	355	77	cancer	cancer	NN
cord-003091-uvfppirt	355	78	Vaccination	Vaccination	NNP
cord-003091-uvfppirt	355	79	with	with	IN
cord-003091-uvfppirt	355	80	mRNA	mrna	NN
cord-003091-uvfppirt	355	81	-	-	HYPH
cord-003091-uvfppirt	355	82	electroporated	electroporate	VBN
cord-003091-uvfppirt	355	83	dendritic	dendritic	JJ
cord-003091-uvfppirt	355	84	cells	cell	NNS
cord-003091-uvfppirt	355	85	induces	induce	VBZ
cord-003091-uvfppirt	355	86	robust	robust	JJ
cord-003091-uvfppirt	355	87	tumor	tumor	NN
cord-003091-uvfppirt	355	88	antigen	antigen	NN
cord-003091-uvfppirt	355	89	-	-	HYPH
cord-003091-uvfppirt	355	90	specific	specific	JJ
cord-003091-uvfppirt	355	91	CD4	CD4	NNP
cord-003091-uvfppirt	355	92	+	+	CC
cord-003091-uvfppirt	355	93	and	and	CC
cord-003091-uvfppirt	355	94	CD8	CD8	NNP
cord-003091-uvfppirt	355	95	+	+	CC
cord-003091-uvfppirt	355	96	T	T	NNP
cord-003091-uvfppirt	355	97	cells	cell	NNS
cord-003091-uvfppirt	355	98	responses	response	NNS
cord-003091-uvfppirt	355	99	in	in	IN
cord-003091-uvfppirt	355	100	stage	stage	NN
cord-003091-uvfppirt	355	101	III	III	NNP
cord-003091-uvfppirt	355	102	and	and	CC
cord-003091-uvfppirt	355	103	IV	IV	NNP
cord-003091-uvfppirt	355	104	melanoma	melanoma	NN
cord-003091-uvfppirt	355	105	patients	patient	NNS
cord-003091-uvfppirt	356	1	Breast	breast	NN
cord-003091-uvfppirt	356	2	cancer	cancer	NN
cord-003091-uvfppirt	356	3	vaccines	vaccine	NNS
cord-003091-uvfppirt	356	4	delivered	deliver	VBN
cord-003091-uvfppirt	356	5	by	by	IN
cord-003091-uvfppirt	356	6	dendritic	dendritic	JJ
cord-003091-uvfppirt	356	7	cell	cell	NN
cord-003091-uvfppirt	356	8	-	-	HYPH
cord-003091-uvfppirt	356	9	targeted	target	VBN
cord-003091-uvfppirt	356	10	lentivectors	lentivector	NNS
cord-003091-uvfppirt	356	11	induce	induce	VBP
cord-003091-uvfppirt	356	12	potent	potent	JJ
cord-003091-uvfppirt	356	13	antitumor	antitumor	JJ
cord-003091-uvfppirt	356	14	immune	immune	JJ
cord-003091-uvfppirt	356	15	responses	response	NNS
cord-003091-uvfppirt	356	16	and	and	CC
cord-003091-uvfppirt	356	17	protect	protect	VB
cord-003091-uvfppirt	356	18	mice	mouse	NNS
cord-003091-uvfppirt	356	19	from	from	IN
cord-003091-uvfppirt	356	20	mammary	mammary	JJ
cord-003091-uvfppirt	356	21	tumor	tumor	NN
cord-003091-uvfppirt	356	22	growth	growth	NN
cord-003091-uvfppirt	356	23	Neoantigens	Neoantigens	NNP
cord-003091-uvfppirt	356	24	in	in	IN
cord-003091-uvfppirt	356	25	cancer	cancer	NN
cord-003091-uvfppirt	356	26	immunotherapy	immunotherapy	NN
cord-003091-uvfppirt	356	27	Personalized	Personalized	NNP
cord-003091-uvfppirt	356	28	cancer	cancer	NN
cord-003091-uvfppirt	356	29	vaccine	vaccine	NN
cord-003091-uvfppirt	356	30	effectively	effectively	RB
cord-003091-uvfppirt	356	31	mobilizes	mobilize	VBZ
cord-003091-uvfppirt	356	32	antitumor	antitumor	JJ
cord-003091-uvfppirt	356	33	T	t	NN
cord-003091-uvfppirt	356	34	cell	cell	NN
cord-003091-uvfppirt	356	35	immunity	immunity	NN
cord-003091-uvfppirt	356	36	in	in	IN
cord-003091-uvfppirt	356	37	ovarian	ovarian	JJ
cord-003091-uvfppirt	356	38	cancer	cancer	NN
cord-003091-uvfppirt	356	39	Personalized	Personalized	NNP
cord-003091-uvfppirt	356	40	RNA	RNA	NNP
cord-003091-uvfppirt	356	41	mutanome	mutanome	NNP
cord-003091-uvfppirt	356	42	vaccines	vaccine	NNS
cord-003091-uvfppirt	356	43	mobilize	mobilize	VBP
cord-003091-uvfppirt	356	44	poly	poly	JJ
cord-003091-uvfppirt	356	45	-	-	HYPH
cord-003091-uvfppirt	356	46	specific	specific	JJ
cord-003091-uvfppirt	356	47	therapeutic	therapeutic	JJ
cord-003091-uvfppirt	356	48	immunity	immunity	NN
cord-003091-uvfppirt	356	49	against	against	IN
cord-003091-uvfppirt	356	50	cancer	cancer	NN
cord-003091-uvfppirt	356	51	An	an	DT
cord-003091-uvfppirt	356	52	immunogenic	immunogenic	JJ
cord-003091-uvfppirt	356	53	personal	personal	JJ
cord-003091-uvfppirt	356	54	neoantigen	neoantigen	NN
cord-003091-uvfppirt	356	55	vaccine	vaccine	NN
cord-003091-uvfppirt	356	56	for	for	IN
cord-003091-uvfppirt	356	57	patients	patient	NNS
cord-003091-uvfppirt	356	58	with	with	IN
cord-003091-uvfppirt	356	59	melanoma	melanoma	NN
cord-003091-uvfppirt	356	60	Vascular	vascular	JJ
cord-003091-uvfppirt	356	61	endothelial	endothelial	JJ
cord-003091-uvfppirt	356	62	growth	growth	NN
cord-003091-uvfppirt	356	63	factor	factor	NN
cord-003091-uvfppirt	356	64	impairs	impair	VBZ
cord-003091-uvfppirt	356	65	the	the	DT
cord-003091-uvfppirt	356	66	functional	functional	JJ
cord-003091-uvfppirt	356	67	ability	ability	NN
cord-003091-uvfppirt	356	68	of	of	IN
cord-003091-uvfppirt	356	69	dendritic	dendritic	JJ
cord-003091-uvfppirt	356	70	cells	cell	NNS
cord-003091-uvfppirt	356	71	through	through	IN
cord-003091-uvfppirt	356	72	I	-PRON-	PRP
cord-003091-uvfppirt	356	73	d	d	NN
cord-003091-uvfppirt	356	74	pathways	pathway	NNS
cord-003091-uvfppirt	357	1	Vascular	vascular	JJ
cord-003091-uvfppirt	357	2	endothelial	endothelial	JJ
cord-003091-uvfppirt	357	3	growth	growth	NN
cord-003091-uvfppirt	357	4	factor	factor	NN
cord-003091-uvfppirt	357	5	inhibits	inhibit	VBZ
cord-003091-uvfppirt	357	6	the	the	DT
cord-003091-uvfppirt	357	7	function	function	NN
cord-003091-uvfppirt	357	8	of	of	IN
cord-003091-uvfppirt	357	9	human	human	JJ
cord-003091-uvfppirt	357	10	mature	mature	JJ
cord-003091-uvfppirt	357	11	dendritic	dendritic	JJ
cord-003091-uvfppirt	357	12	cells	cell	NNS
cord-003091-uvfppirt	357	13	mediated	mediate	VBN
cord-003091-uvfppirt	357	14	by	by	IN
cord-003091-uvfppirt	357	15	VEGF	VEGF	NNP
cord-003091-uvfppirt	357	16	receptor-2	receptor-2	NNP
cord-003091-uvfppirt	357	17	High	high	JJ
cord-003091-uvfppirt	357	18	co	co	NN
cord-003091-uvfppirt	357	19	-	-	NN
cord-003091-uvfppirt	357	20	expression	expression	NN
cord-003091-uvfppirt	357	21	of	of	IN
cord-003091-uvfppirt	357	22	IL-34	IL-34	NNP
cord-003091-uvfppirt	357	23	and	and	CC
cord-003091-uvfppirt	357	24	M	M	NNP
cord-003091-uvfppirt	357	25	-	-	HYPH
cord-003091-uvfppirt	357	26	CSF	CSF	NNP
cord-003091-uvfppirt	357	27	correlates	correlate	VBZ
cord-003091-uvfppirt	357	28	with	with	IN
cord-003091-uvfppirt	357	29	tumor	tumor	NN
cord-003091-uvfppirt	357	30	progression	progression	NN
cord-003091-uvfppirt	357	31	and	and	CC
cord-003091-uvfppirt	357	32	poor	poor	JJ
cord-003091-uvfppirt	357	33	survival	survival	NN
cord-003091-uvfppirt	357	34	in	in	IN
cord-003091-uvfppirt	357	35	lung	lung	NN
cord-003091-uvfppirt	357	36	cancers	cancer	NNS
cord-003091-uvfppirt	358	1	Tumor	tumor	NN
cord-003091-uvfppirt	358	2	-	-	HYPH
cord-003091-uvfppirt	358	3	derived	derive	VBN
cord-003091-uvfppirt	358	4	TGF	TGF	NNP
cord-003091-uvfppirt	358	5	-	-	HYPH
cord-003091-uvfppirt	358	6	β	β	NN
cord-003091-uvfppirt	358	7	reduces	reduce	VBZ
cord-003091-uvfppirt	358	8	the	the	DT
cord-003091-uvfppirt	358	9	efficacy	efficacy	NN
cord-003091-uvfppirt	358	10	of	of	IN
cord-003091-uvfppirt	358	11	dendritic	dendritic	JJ
cord-003091-uvfppirt	358	12	cell	cell	NN
cord-003091-uvfppirt	358	13	/	/	SYM
cord-003091-uvfppirt	358	14	tumor	tumor	NN
cord-003091-uvfppirt	358	15	fusion	fusion	NN
cord-003091-uvfppirt	358	16	vaccine	vaccine	NN
cord-003091-uvfppirt	358	17	Serum	serum	NN
cord-003091-uvfppirt	358	18	IL-10	IL-10	NNP
cord-003091-uvfppirt	359	1	predicts	predict	VBZ
cord-003091-uvfppirt	359	2	worse	bad	JJR
cord-003091-uvfppirt	359	3	outcome	outcome	NN
cord-003091-uvfppirt	359	4	in	in	IN
cord-003091-uvfppirt	359	5	cancer	cancer	NN
cord-003091-uvfppirt	359	6	patients	patient	NNS
cord-003091-uvfppirt	359	7	:	:	:
cord-003091-uvfppirt	360	1	a	a	DT
cord-003091-uvfppirt	360	2	meta	meta	JJ
cord-003091-uvfppirt	360	3	-	-	HYPH
cord-003091-uvfppirt	360	4	analysis	analysis	NN
cord-003091-uvfppirt	360	5	IL-10	IL-10	NNP
cord-003091-uvfppirt	360	6	:	:	:
cord-003091-uvfppirt	360	7	master	master	NN
cord-003091-uvfppirt	360	8	switch	switch	VB
cord-003091-uvfppirt	360	9	from	from	IN
cord-003091-uvfppirt	360	10	tumor	tumor	NN
cord-003091-uvfppirt	360	11	-	-	HYPH
cord-003091-uvfppirt	360	12	promoting	promote	VBG
cord-003091-uvfppirt	360	13	in	in	IN
cord-003091-uvfppirt	360	14	flammation	flammation	NN
cord-003091-uvfppirt	360	15	to	to	IN
cord-003091-uvfppirt	360	16	antitumor	antitumor	JJ
cord-003091-uvfppirt	360	17	immunity	immunity	NN
cord-003091-uvfppirt	360	18	Immune	immune	JJ
cord-003091-uvfppirt	360	19	cell	cell	NN
cord-003091-uvfppirt	360	20	dysfunctions	dysfunction	NNS
cord-003091-uvfppirt	360	21	in	in	IN
cord-003091-uvfppirt	360	22	breast	breast	NN
cord-003091-uvfppirt	360	23	cancer	cancer	NN
cord-003091-uvfppirt	360	24	patients	patient	NNS
cord-003091-uvfppirt	360	25	detected	detect	VBD
cord-003091-uvfppirt	360	26	through	through	IN
cord-003091-uvfppirt	360	27	whole	whole	JJ
cord-003091-uvfppirt	360	28	blood	blood	NN
cord-003091-uvfppirt	360	29	multi	multi	JJ
cord-003091-uvfppirt	360	30	-	-	JJ
cord-003091-uvfppirt	360	31	parametric	parametric	JJ
cord-003091-uvfppirt	360	32	flow	flow	NN
cord-003091-uvfppirt	360	33	cytometry	cytometry	NN
cord-003091-uvfppirt	360	34	assay	assay	NN
cord-003091-uvfppirt	360	35	Inhibition	inhibition	NN
cord-003091-uvfppirt	360	36	of	of	IN
cord-003091-uvfppirt	360	37	dendritic	dendritic	JJ
cord-003091-uvfppirt	360	38	cell	cell	NN
cord-003091-uvfppirt	360	39	migration	migration	NN
cord-003091-uvfppirt	360	40	by	by	IN
cord-003091-uvfppirt	360	41	transforming	transform	VBG
cord-003091-uvfppirt	360	42	growth	growth	NN
cord-003091-uvfppirt	360	43	factor	factor	NN
cord-003091-uvfppirt	360	44	-	-	HYPH
cord-003091-uvfppirt	360	45	b	b	NN
cord-003091-uvfppirt	360	46	1	1	CD
cord-003091-uvfppirt	360	47	increases	increase	VBZ
cord-003091-uvfppirt	360	48	tumor	tumor	NN
cord-003091-uvfppirt	360	49	-	-	HYPH
cord-003091-uvfppirt	360	50	draining	drain	VBG
cord-003091-uvfppirt	360	51	lymph	lymph	NN
cord-003091-uvfppirt	360	52	node	node	NN
cord-003091-uvfppirt	360	53	meta	meta	NNP
cord-003091-uvfppirt	360	54	stasis	stasis	NN
cord-003091-uvfppirt	361	1	Effective	effective	JJ
cord-003091-uvfppirt	361	2	clinical	clinical	JJ
cord-003091-uvfppirt	361	3	responses	response	NNS
cord-003091-uvfppirt	361	4	in	in	IN
cord-003091-uvfppirt	361	5	metastatic	metastatic	JJ
cord-003091-uvfppirt	361	6	melanoma	melanoma	NN
cord-003091-uvfppirt	361	7	patients	patient	NNS
cord-003091-uvfppirt	361	8	after	after	IN
cord-003091-uvfppirt	361	9	vaccination	vaccination	NN
cord-003091-uvfppirt	361	10	with	with	IN
cord-003091-uvfppirt	361	11	primary	primary	JJ
cord-003091-uvfppirt	361	12	myeloid	myeloid	NN
cord-003091-uvfppirt	361	13	dendritic	dendritic	JJ
cord-003091-uvfppirt	361	14	cells	cell	NNS
cord-003091-uvfppirt	361	15	Classical	classical	JJ
cord-003091-uvfppirt	361	16	Flt3L	flt3l	NN
cord-003091-uvfppirt	361	17	-	-	HYPH
cord-003091-uvfppirt	361	18	dependent	dependent	JJ
cord-003091-uvfppirt	361	19	dendritic	dendritic	JJ
cord-003091-uvfppirt	361	20	cells	cell	NNS
cord-003091-uvfppirt	361	21	control	control	VBP
cord-003091-uvfppirt	361	22	immunity	immunity	NN
cord-003091-uvfppirt	361	23	to	to	IN
cord-003091-uvfppirt	361	24	protein	protein	NN
cord-003091-uvfppirt	361	25	vaccine	vaccine	NN
cord-003091-uvfppirt	362	1	FLT3	flt3	NN
cord-003091-uvfppirt	362	2	ligand	ligand	NN
cord-003091-uvfppirt	362	3	enhances	enhance	VBZ
cord-003091-uvfppirt	362	4	the	the	DT
cord-003091-uvfppirt	362	5	cancer	cancer	NN
cord-003091-uvfppirt	362	6	therapeutic	therapeutic	JJ
cord-003091-uvfppirt	362	7	potency	potency	NN
cord-003091-uvfppirt	362	8	of	of	IN
cord-003091-uvfppirt	362	9	naked	naked	JJ
cord-003091-uvfppirt	362	10	RNA	RNA	NNP
cord-003091-uvfppirt	362	11	vaccines	vaccine	NNS
cord-003091-uvfppirt	362	12	Dendritic	dendritic	JJ
cord-003091-uvfppirt	362	13	cell	cell	NN
cord-003091-uvfppirt	362	14	-	-	HYPH
cord-003091-uvfppirt	362	15	specific	specific	JJ
cord-003091-uvfppirt	362	16	delivery	delivery	NN
cord-003091-uvfppirt	362	17	of	of	IN
cord-003091-uvfppirt	362	18	Flt3L	flt3l	NN
cord-003091-uvfppirt	362	19	by	by	IN
cord-003091-uvfppirt	362	20	coronavirus	coronavirus	NN
cord-003091-uvfppirt	362	21	vectors	vector	NNS
cord-003091-uvfppirt	362	22	secures	secure	VBZ
cord-003091-uvfppirt	362	23	induction	induction	NN
cord-003091-uvfppirt	362	24	of	of	IN
cord-003091-uvfppirt	362	25	therapeutic	therapeutic	JJ
cord-003091-uvfppirt	362	26	antitumor	antitumor	NN
cord-003091-uvfppirt	362	27	immunity	immunity	NN
cord-003091-uvfppirt	363	1	PD-1	PD-1	NNP
cord-003091-uvfppirt	364	1	blockade	blockade	NN
cord-003091-uvfppirt	364	2	enhances	enhance	VBZ
cord-003091-uvfppirt	364	3	the	the	DT
cord-003091-uvfppirt	364	4	vaccination	vaccination	NN
cord-003091-uvfppirt	364	5	-	-	HYPH
cord-003091-uvfppirt	364	6	induced	induce	VBN
cord-003091-uvfppirt	364	7	immune	immune	JJ
cord-003091-uvfppirt	364	8	response	response	NN
cord-003091-uvfppirt	364	9	in	in	IN
cord-003091-uvfppirt	364	10	glioma	glioma	NN
cord-003091-uvfppirt	364	11	Silencing	silence	VBG
cord-003091-uvfppirt	364	12	IDO	IDO	NNP
cord-003091-uvfppirt	364	13	in	in	IN
cord-003091-uvfppirt	364	14	dendritic	dendritic	JJ
cord-003091-uvfppirt	364	15	cells	cell	NNS
cord-003091-uvfppirt	364	16	:	:	:
cord-003091-uvfppirt	364	17	a	a	DT
cord-003091-uvfppirt	364	18	novel	novel	JJ
cord-003091-uvfppirt	364	19	approach	approach	NN
cord-003091-uvfppirt	364	20	to	to	TO
cord-003091-uvfppirt	364	21	enhance	enhance	VB
cord-003091-uvfppirt	364	22	cancer	cancer	NN
cord-003091-uvfppirt	364	23	immunotherapy	immunotherapy	NN
cord-003091-uvfppirt	364	24	in	in	IN
cord-003091-uvfppirt	364	25	a	a	DT
cord-003091-uvfppirt	364	26	murine	murine	JJ
cord-003091-uvfppirt	364	27	breast	breast	NN
cord-003091-uvfppirt	364	28	cancer	cancer	NN
cord-003091-uvfppirt	364	29	model	model	NN
cord-003091-uvfppirt	364	30	Searching	search	VBG
cord-003091-uvfppirt	364	31	for	for	IN
cord-003091-uvfppirt	364	32	the	the	DT
cord-003091-uvfppirt	364	33	human	human	JJ
cord-003091-uvfppirt	364	34	genetic	genetic	JJ
cord-003091-uvfppirt	364	35	factors	factor	NNS
cord-003091-uvfppirt	364	36	standing	stand	VBG
cord-003091-uvfppirt	364	37	in	in	IN
cord-003091-uvfppirt	364	38	the	the	DT
cord-003091-uvfppirt	364	39	way	way	NN
cord-003091-uvfppirt	364	40	of	of	IN
cord-003091-uvfppirt	364	41	universally	universally	RB
cord-003091-uvfppirt	364	42	effective	effective	JJ
cord-003091-uvfppirt	364	43	vaccines	vaccine	NNS
cord-003091-uvfppirt	364	44	Global	global	JJ
cord-003091-uvfppirt	364	45	analyses	analysis	NNS
cord-003091-uvfppirt	364	46	of	of	IN
cord-003091-uvfppirt	364	47	human	human	JJ
cord-003091-uvfppirt	364	48	immune	immune	JJ
cord-003091-uvfppirt	364	49	variation	variation	NN
cord-003091-uvfppirt	364	50	reveal	reveal	VBP
cord-003091-uvfppirt	364	51	baseline	baseline	JJ
cord-003091-uvfppirt	364	52	predictors	predictor	NNS
cord-003091-uvfppirt	364	53	of	of	IN
cord-003091-uvfppirt	364	54	postvaccination	postvaccination	NN
cord-003091-uvfppirt	364	55	responses	response	NNS