id sid tid token lemma pos cord-003571-upogtny6 1 1 key key NN cord-003571-upogtny6 1 2 : : : cord-003571-upogtny6 1 3 cord-003571-upogtny6 cord-003571-upogtny6 VBG cord-003571-upogtny6 1 4 authors author NNS cord-003571-upogtny6 1 5 : : : cord-003571-upogtny6 1 6 Viboud Viboud NNP cord-003571-upogtny6 1 7 , , , cord-003571-upogtny6 1 8 Cécile Cécile NNP cord-003571-upogtny6 1 9 ; ; : cord-003571-upogtny6 1 10 Lessler Lessler NNP cord-003571-upogtny6 1 11 , , , cord-003571-upogtny6 1 12 Justin Justin NNP cord-003571-upogtny6 1 13 title title NN cord-003571-upogtny6 1 14 : : : cord-003571-upogtny6 2 1 The the DT cord-003571-upogtny6 2 2 1918 1918 CD cord-003571-upogtny6 2 3 Influenza Influenza NNP cord-003571-upogtny6 2 4 Pandemic Pandemic NNP cord-003571-upogtny6 2 5 : : : cord-003571-upogtny6 2 6 Looking look VBG cord-003571-upogtny6 2 7 Back back RB cord-003571-upogtny6 2 8 , , , cord-003571-upogtny6 2 9 Looking look VBG cord-003571-upogtny6 2 10 Forward Forward NNP cord-003571-upogtny6 2 11 date date NN cord-003571-upogtny6 2 12 : : : cord-003571-upogtny6 2 13 2018 2018 CD cord-003571-upogtny6 2 14 - - SYM cord-003571-upogtny6 2 15 10 10 CD cord-003571-upogtny6 2 16 - - SYM cord-003571-upogtny6 2 17 20 20 CD cord-003571-upogtny6 2 18 journal journal NN cord-003571-upogtny6 2 19 : : : cord-003571-upogtny6 3 1 Am be VBP cord-003571-upogtny6 3 2 J J NNP cord-003571-upogtny6 3 3 Epidemiol Epidemiol NNP cord-003571-upogtny6 3 4 DOI doi NN cord-003571-upogtny6 3 5 : : : cord-003571-upogtny6 4 1 10.1093 10.1093 CD cord-003571-upogtny6 4 2 / / SYM cord-003571-upogtny6 4 3 aje aje NNP cord-003571-upogtny6 4 4 / / , cord-003571-upogtny6 4 5 kwy207 kwy207 NNP cord-003571-upogtny6 4 6 sha sha NNP cord-003571-upogtny6 4 7 : : : cord-003571-upogtny6 4 8 83a7484bf325c605f93c0888230c543f3a148add 83a7484bf325c605f93c0888230c543f3a148add CD cord-003571-upogtny6 4 9 doc_id doc_id CD cord-003571-upogtny6 4 10 : : : cord-003571-upogtny6 4 11 3571 3571 CD cord-003571-upogtny6 4 12 cord_uid cord_uid NNS cord-003571-upogtny6 4 13 : : : cord-003571-upogtny6 4 14 upogtny6 upogtny6 VBN cord-003571-upogtny6 5 1 In in IN cord-003571-upogtny6 5 2 commemoration commemoration NN cord-003571-upogtny6 5 3 of of IN cord-003571-upogtny6 5 4 the the DT cord-003571-upogtny6 5 5 centennial centennial NN cord-003571-upogtny6 5 6 of of IN cord-003571-upogtny6 5 7 the the DT cord-003571-upogtny6 5 8 1918 1918 CD cord-003571-upogtny6 5 9 influenza influenza NN cord-003571-upogtny6 5 10 pandemic pandemic NN cord-003571-upogtny6 5 11 , , , cord-003571-upogtny6 5 12 the the DT cord-003571-upogtny6 5 13 American American NNP cord-003571-upogtny6 5 14 Journal Journal NNP cord-003571-upogtny6 5 15 of of IN cord-003571-upogtny6 5 16 Epidemiology Epidemiology NNP cord-003571-upogtny6 5 17 has have VBZ cord-003571-upogtny6 5 18 convened convene VBN cord-003571-upogtny6 5 19 a a DT cord-003571-upogtny6 5 20 collection collection NN cord-003571-upogtny6 5 21 of of IN cord-003571-upogtny6 5 22 12 12 CD cord-003571-upogtny6 5 23 articles article NNS cord-003571-upogtny6 5 24 that that WDT cord-003571-upogtny6 5 25 further further RB cord-003571-upogtny6 5 26 illuminate illuminate VBP cord-003571-upogtny6 5 27 the the DT cord-003571-upogtny6 5 28 epidemiology epidemiology NN cord-003571-upogtny6 5 29 of of IN cord-003571-upogtny6 5 30 that that DT cord-003571-upogtny6 5 31 pandemic pandemic NN cord-003571-upogtny6 5 32 and and CC cord-003571-upogtny6 5 33 consider consider VB cord-003571-upogtny6 5 34 whether whether IN cord-003571-upogtny6 5 35 we -PRON- PRP cord-003571-upogtny6 5 36 would would MD cord-003571-upogtny6 5 37 be be VB cord-003571-upogtny6 5 38 more more RBR cord-003571-upogtny6 5 39 prepared prepared JJ cord-003571-upogtny6 5 40 if if IN cord-003571-upogtny6 5 41 an an DT cord-003571-upogtny6 5 42 equally equally RB cord-003571-upogtny6 5 43 deadly deadly JJ cord-003571-upogtny6 5 44 influenza influenza NN cord-003571-upogtny6 5 45 virus virus NN cord-003571-upogtny6 5 46 were be VBD cord-003571-upogtny6 5 47 to to TO cord-003571-upogtny6 5 48 emerge emerge VB cord-003571-upogtny6 5 49 again again RB cord-003571-upogtny6 5 50 . . . cord-003571-upogtny6 6 1 In in IN cord-003571-upogtny6 6 2 the the DT cord-003571-upogtny6 6 3 present present JJ cord-003571-upogtny6 6 4 commentary commentary NN cord-003571-upogtny6 6 5 , , , cord-003571-upogtny6 6 6 we -PRON- PRP cord-003571-upogtny6 6 7 place place VBP cord-003571-upogtny6 6 8 these these DT cord-003571-upogtny6 6 9 12 12 CD cord-003571-upogtny6 6 10 articles article NNS cord-003571-upogtny6 6 11 in in IN cord-003571-upogtny6 6 12 the the DT cord-003571-upogtny6 6 13 context context NN cord-003571-upogtny6 6 14 of of IN cord-003571-upogtny6 6 15 a a DT cord-003571-upogtny6 6 16 growing grow VBG cord-003571-upogtny6 6 17 body body NN cord-003571-upogtny6 6 18 of of IN cord-003571-upogtny6 6 19 work work NN cord-003571-upogtny6 6 20 on on IN cord-003571-upogtny6 6 21 the the DT cord-003571-upogtny6 6 22 archeo archeo NN cord-003571-upogtny6 6 23 - - HYPH cord-003571-upogtny6 6 24 epidemiology epidemiology NN cord-003571-upogtny6 6 25 of of IN cord-003571-upogtny6 6 26 past past JJ cord-003571-upogtny6 6 27 pandemics pandemic NNS cord-003571-upogtny6 6 28 , , , cord-003571-upogtny6 6 29 the the DT cord-003571-upogtny6 6 30 socioeconomic socioeconomic JJ cord-003571-upogtny6 6 31 and and CC cord-003571-upogtny6 6 32 geographic geographic JJ cord-003571-upogtny6 6 33 drivers driver NNS cord-003571-upogtny6 6 34 of of IN cord-003571-upogtny6 6 35 influenza influenza NN cord-003571-upogtny6 6 36 mortality mortality NN cord-003571-upogtny6 6 37 and and CC cord-003571-upogtny6 6 38 natality natality NN cord-003571-upogtny6 6 39 impact impact NN cord-003571-upogtny6 6 40 , , , cord-003571-upogtny6 6 41 and and CC cord-003571-upogtny6 6 42 renewed renew VBD cord-003571-upogtny6 6 43 interest interest NN cord-003571-upogtny6 6 44 in in IN cord-003571-upogtny6 6 45 immune immune JJ cord-003571-upogtny6 6 46 imprinting imprinting NN cord-003571-upogtny6 6 47 mechanisms mechanism NNS cord-003571-upogtny6 6 48 and and CC cord-003571-upogtny6 6 49 the the DT cord-003571-upogtny6 6 50 development development NN cord-003571-upogtny6 6 51 of of IN cord-003571-upogtny6 6 52 novel novel JJ cord-003571-upogtny6 6 53 influenza influenza NN cord-003571-upogtny6 6 54 vaccines vaccine NNS cord-003571-upogtny6 6 55 . . . cord-003571-upogtny6 7 1 We -PRON- PRP cord-003571-upogtny6 7 2 also also RB cord-003571-upogtny6 7 3 highlight highlight VBP cord-003571-upogtny6 7 4 persisting persist VBG cord-003571-upogtny6 7 5 mysteries mystery NNS cord-003571-upogtny6 7 6 in in IN cord-003571-upogtny6 7 7 the the DT cord-003571-upogtny6 7 8 origins origin NNS cord-003571-upogtny6 7 9 and and CC cord-003571-upogtny6 7 10 severity severity NN cord-003571-upogtny6 7 11 of of IN cord-003571-upogtny6 7 12 the the DT cord-003571-upogtny6 7 13 1918 1918 CD cord-003571-upogtny6 7 14 pandemic pandemic NN cord-003571-upogtny6 7 15 and and CC cord-003571-upogtny6 7 16 the the DT cord-003571-upogtny6 7 17 need need NN cord-003571-upogtny6 7 18 to to TO cord-003571-upogtny6 7 19 preserve preserve VB cord-003571-upogtny6 7 20 rapidly rapidly RB cord-003571-upogtny6 7 21 decaying decay VBG cord-003571-upogtny6 7 22 information information NN cord-003571-upogtny6 7 23 that that WDT cord-003571-upogtny6 7 24 may may MD cord-003571-upogtny6 7 25 provide provide VB cord-003571-upogtny6 7 26 treasure treasure NN cord-003571-upogtny6 7 27 troves trove NNS cord-003571-upogtny6 7 28 for for IN cord-003571-upogtny6 7 29 future future JJ cord-003571-upogtny6 7 30 generations generation NNS cord-003571-upogtny6 7 31 . . . cord-003571-upogtny6 8 1 Initially initially RB cord-003571-upogtny6 8 2 submitted submit VBN cord-003571-upogtny6 8 3 August August NNP cord-003571-upogtny6 8 4 28 28 CD cord-003571-upogtny6 8 5 , , , cord-003571-upogtny6 8 6 2018 2018 CD cord-003571-upogtny6 8 7 ; ; , cord-003571-upogtny6 8 8 accepted accept VBN cord-003571-upogtny6 8 9 for for IN cord-003571-upogtny6 8 10 publication publication NN cord-003571-upogtny6 8 11 September September NNP cord-003571-upogtny6 8 12 6 6 CD cord-003571-upogtny6 8 13 , , , cord-003571-upogtny6 8 14 2018 2018 CD cord-003571-upogtny6 8 15 . . . cord-003571-upogtny6 9 1 In in IN cord-003571-upogtny6 9 2 commemoration commemoration NN cord-003571-upogtny6 9 3 of of IN cord-003571-upogtny6 9 4 the the DT cord-003571-upogtny6 9 5 centennial centennial NN cord-003571-upogtny6 9 6 of of IN cord-003571-upogtny6 9 7 the the DT cord-003571-upogtny6 9 8 1918 1918 CD cord-003571-upogtny6 9 9 influenza influenza NN cord-003571-upogtny6 9 10 pandemic pandemic NN cord-003571-upogtny6 9 11 , , , cord-003571-upogtny6 9 12 the the DT cord-003571-upogtny6 9 13 American American NNP cord-003571-upogtny6 9 14 Journal Journal NNP cord-003571-upogtny6 9 15 of of IN cord-003571-upogtny6 9 16 Epidemiology Epidemiology NNP cord-003571-upogtny6 9 17 has have VBZ cord-003571-upogtny6 9 18 convened convene VBN cord-003571-upogtny6 9 19 a a DT cord-003571-upogtny6 9 20 collection collection NN cord-003571-upogtny6 9 21 of of IN cord-003571-upogtny6 9 22 12 12 CD cord-003571-upogtny6 9 23 articles article NNS cord-003571-upogtny6 9 24 that that WDT cord-003571-upogtny6 9 25 further further RB cord-003571-upogtny6 9 26 illuminate illuminate VBP cord-003571-upogtny6 9 27 the the DT cord-003571-upogtny6 9 28 epidemiology epidemiology NN cord-003571-upogtny6 9 29 of of IN cord-003571-upogtny6 9 30 that that DT cord-003571-upogtny6 9 31 pandemic pandemic NN cord-003571-upogtny6 9 32 and and CC cord-003571-upogtny6 9 33 consider consider VB cord-003571-upogtny6 9 34 whether whether IN cord-003571-upogtny6 9 35 we -PRON- PRP cord-003571-upogtny6 9 36 would would MD cord-003571-upogtny6 9 37 be be VB cord-003571-upogtny6 9 38 more more RBR cord-003571-upogtny6 9 39 prepared prepared JJ cord-003571-upogtny6 9 40 if if IN cord-003571-upogtny6 9 41 an an DT cord-003571-upogtny6 9 42 equally equally RB cord-003571-upogtny6 9 43 deadly deadly JJ cord-003571-upogtny6 9 44 influenza influenza NN cord-003571-upogtny6 9 45 virus virus NN cord-003571-upogtny6 9 46 were be VBD cord-003571-upogtny6 9 47 to to TO cord-003571-upogtny6 9 48 emerge emerge VB cord-003571-upogtny6 9 49 again again RB cord-003571-upogtny6 9 50 . . . cord-003571-upogtny6 10 1 In in IN cord-003571-upogtny6 10 2 the the DT cord-003571-upogtny6 10 3 present present JJ cord-003571-upogtny6 10 4 commentary commentary NN cord-003571-upogtny6 10 5 , , , cord-003571-upogtny6 10 6 we -PRON- PRP cord-003571-upogtny6 10 7 place place VBP cord-003571-upogtny6 10 8 these these DT cord-003571-upogtny6 10 9 12 12 CD cord-003571-upogtny6 10 10 articles article NNS cord-003571-upogtny6 10 11 in in IN cord-003571-upogtny6 10 12 the the DT cord-003571-upogtny6 10 13 context context NN cord-003571-upogtny6 10 14 of of IN cord-003571-upogtny6 10 15 a a DT cord-003571-upogtny6 10 16 growing grow VBG cord-003571-upogtny6 10 17 body body NN cord-003571-upogtny6 10 18 of of IN cord-003571-upogtny6 10 19 work work NN cord-003571-upogtny6 10 20 on on IN cord-003571-upogtny6 10 21 the the DT cord-003571-upogtny6 10 22 archeo archeo NN cord-003571-upogtny6 10 23 - - HYPH cord-003571-upogtny6 10 24 epidemiology epidemiology NN cord-003571-upogtny6 10 25 of of IN cord-003571-upogtny6 10 26 past past JJ cord-003571-upogtny6 10 27 pandemics pandemic NNS cord-003571-upogtny6 10 28 , , , cord-003571-upogtny6 10 29 the the DT cord-003571-upogtny6 10 30 socioeconomic socioeconomic JJ cord-003571-upogtny6 10 31 and and CC cord-003571-upogtny6 10 32 geographic geographic JJ cord-003571-upogtny6 10 33 drivers driver NNS cord-003571-upogtny6 10 34 of of IN cord-003571-upogtny6 10 35 influenza influenza NN cord-003571-upogtny6 10 36 mortality mortality NN cord-003571-upogtny6 10 37 and and CC cord-003571-upogtny6 10 38 natality natality NN cord-003571-upogtny6 10 39 impact impact NN cord-003571-upogtny6 10 40 , , , cord-003571-upogtny6 10 41 and and CC cord-003571-upogtny6 10 42 renewed renew VBD cord-003571-upogtny6 10 43 interest interest NN cord-003571-upogtny6 10 44 in in IN cord-003571-upogtny6 10 45 immune immune JJ cord-003571-upogtny6 10 46 imprinting imprinting NN cord-003571-upogtny6 10 47 mechanisms mechanism NNS cord-003571-upogtny6 10 48 and and CC cord-003571-upogtny6 10 49 the the DT cord-003571-upogtny6 10 50 development development NN cord-003571-upogtny6 10 51 of of IN cord-003571-upogtny6 10 52 novel novel JJ cord-003571-upogtny6 10 53 influenza influenza NN cord-003571-upogtny6 10 54 vaccines vaccine NNS cord-003571-upogtny6 10 55 . . . cord-003571-upogtny6 11 1 We -PRON- PRP cord-003571-upogtny6 11 2 also also RB cord-003571-upogtny6 11 3 highlight highlight VBP cord-003571-upogtny6 11 4 persisting persist VBG cord-003571-upogtny6 11 5 mysteries mystery NNS cord-003571-upogtny6 11 6 in in IN cord-003571-upogtny6 11 7 the the DT cord-003571-upogtny6 11 8 origins origin NNS cord-003571-upogtny6 11 9 and and CC cord-003571-upogtny6 11 10 severity severity NN cord-003571-upogtny6 11 11 of of IN cord-003571-upogtny6 11 12 the the DT cord-003571-upogtny6 11 13 1918 1918 CD cord-003571-upogtny6 11 14 pandemic pandemic NN cord-003571-upogtny6 11 15 and and CC cord-003571-upogtny6 11 16 the the DT cord-003571-upogtny6 11 17 need need NN cord-003571-upogtny6 11 18 to to TO cord-003571-upogtny6 11 19 preserve preserve VB cord-003571-upogtny6 11 20 rapidly rapidly RB cord-003571-upogtny6 11 21 decaying decay VBG cord-003571-upogtny6 11 22 information information NN cord-003571-upogtny6 11 23 that that WDT cord-003571-upogtny6 11 24 may may MD cord-003571-upogtny6 11 25 provide provide VB cord-003571-upogtny6 11 26 treasure treasure NN cord-003571-upogtny6 11 27 troves trove NNS cord-003571-upogtny6 11 28 for for IN cord-003571-upogtny6 11 29 future future JJ cord-003571-upogtny6 11 30 generations generation NNS cord-003571-upogtny6 11 31 . . . cord-003571-upogtny6 12 1 age age NN cord-003571-upogtny6 12 2 patterns pattern NNS cord-003571-upogtny6 12 3 ; ; : cord-003571-upogtny6 12 4 history history NN cord-003571-upogtny6 12 5 of of IN cord-003571-upogtny6 12 6 epidemiology epidemiology NN cord-003571-upogtny6 12 7 ; ; , cord-003571-upogtny6 12 8 influenza influenza NN cord-003571-upogtny6 12 9 ; ; : cord-003571-upogtny6 12 10 mortality mortality NN cord-003571-upogtny6 12 11 ; ; : cord-003571-upogtny6 12 12 pandemic pandemic NN cord-003571-upogtny6 12 13 ; ; : cord-003571-upogtny6 12 14 prior prior JJ cord-003571-upogtny6 12 15 immunity immunity NN cord-003571-upogtny6 12 16 One one CD cord-003571-upogtny6 12 17 hundred hundred CD cord-003571-upogtny6 12 18 years year NNS cord-003571-upogtny6 12 19 after after IN cord-003571-upogtny6 12 20 the the DT cord-003571-upogtny6 12 21 fact fact NN cord-003571-upogtny6 12 22 , , , cord-003571-upogtny6 12 23 the the DT cord-003571-upogtny6 12 24 1918 1918 CD cord-003571-upogtny6 12 25 influenza influenza NN cord-003571-upogtny6 12 26 pandemic pandemic NN cord-003571-upogtny6 12 27 remains remain VBZ cord-003571-upogtny6 12 28 one one CD cord-003571-upogtny6 12 29 of of IN cord-003571-upogtny6 12 30 the the DT cord-003571-upogtny6 12 31 most most RBS cord-003571-upogtny6 12 32 important important JJ cord-003571-upogtny6 12 33 epidemics epidemic NNS cord-003571-upogtny6 12 34 of of IN cord-003571-upogtny6 12 35 the the DT cord-003571-upogtny6 12 36 modern modern JJ cord-003571-upogtny6 12 37 medical medical JJ cord-003571-upogtny6 12 38 era era NN cord-003571-upogtny6 12 39 ; ; : cord-003571-upogtny6 12 40 it -PRON- PRP cord-003571-upogtny6 12 41 was be VBD cord-003571-upogtny6 12 42 significant significant JJ cord-003571-upogtny6 12 43 for for IN cord-003571-upogtny6 12 44 its -PRON- PRP$ cord-003571-upogtny6 12 45 impact impact NN cord-003571-upogtny6 12 46 on on IN cord-003571-upogtny6 12 47 both both DT cord-003571-upogtny6 12 48 human human JJ cord-003571-upogtny6 12 49 health health NN cord-003571-upogtny6 12 50 and and CC cord-003571-upogtny6 12 51 the the DT cord-003571-upogtny6 12 52 development development NN cord-003571-upogtny6 12 53 of of IN cord-003571-upogtny6 12 54 epidemiology epidemiology NN cord-003571-upogtny6 12 55 and and CC cord-003571-upogtny6 12 56 other other JJ cord-003571-upogtny6 12 57 medical medical JJ cord-003571-upogtny6 12 58 sciences science NNS cord-003571-upogtny6 12 59 . . . cord-003571-upogtny6 13 1 Still still RB cord-003571-upogtny6 13 2 , , , cord-003571-upogtny6 13 3 as as IN cord-003571-upogtny6 13 4 we -PRON- PRP cord-003571-upogtny6 13 5 mark mark VBP cord-003571-upogtny6 13 6 its -PRON- PRP$ cord-003571-upogtny6 13 7 centennial centennial NN cord-003571-upogtny6 13 8 , , , cord-003571-upogtny6 13 9 it -PRON- PRP cord-003571-upogtny6 13 10 is be VBZ cord-003571-upogtny6 13 11 sobering sobering JJ cord-003571-upogtny6 13 12 to to TO cord-003571-upogtny6 13 13 realize realize VB cord-003571-upogtny6 13 14 how how WRB cord-003571-upogtny6 13 15 little little JJ cord-003571-upogtny6 13 16 we -PRON- PRP cord-003571-upogtny6 13 17 understand understand VBP cord-003571-upogtny6 13 18 about about IN cord-003571-upogtny6 13 19 the the DT cord-003571-upogtny6 13 20 origins origin NNS cord-003571-upogtny6 13 21 and and CC cord-003571-upogtny6 13 22 lethality lethality NN cord-003571-upogtny6 13 23 of of IN cord-003571-upogtny6 13 24 this this DT cord-003571-upogtny6 13 25 unusual unusual JJ cord-003571-upogtny6 13 26 outbreak outbreak NN cord-003571-upogtny6 13 27 despite despite IN cord-003571-upogtny6 13 28 decades decade NNS cord-003571-upogtny6 13 29 of of IN cord-003571-upogtny6 13 30 intense intense JJ cord-003571-upogtny6 13 31 multidisciplinary multidisciplinary JJ cord-003571-upogtny6 13 32 research research NN cord-003571-upogtny6 13 33 . . . cord-003571-upogtny6 14 1 Although although IN cord-003571-upogtny6 14 2 it -PRON- PRP cord-003571-upogtny6 14 3 would would MD cord-003571-upogtny6 14 4 be be VB cord-003571-upogtny6 14 5 80 80 CD cord-003571-upogtny6 14 6 years year NNS cord-003571-upogtny6 14 7 before before IN cord-003571-upogtny6 14 8 it -PRON- PRP cord-003571-upogtny6 14 9 was be VBD cord-003571-upogtny6 14 10 possible possible JJ cord-003571-upogtny6 14 11 to to TO cord-003571-upogtny6 14 12 fully fully RB cord-003571-upogtny6 14 13 characterize characterize VB cord-003571-upogtny6 14 14 the the DT cord-003571-upogtny6 14 15 virus virus NN cord-003571-upogtny6 14 16 responsible responsible JJ cord-003571-upogtny6 14 17 for for IN cord-003571-upogtny6 14 18 the the DT cord-003571-upogtny6 14 19 1918 1918 CD cord-003571-upogtny6 14 20 pandemic pandemic NN cord-003571-upogtny6 14 21 ( ( -LRB- cord-003571-upogtny6 14 22 1 1 CD cord-003571-upogtny6 14 23 ) ) -RRB- cord-003571-upogtny6 14 24 , , , cord-003571-upogtny6 14 25 contemporaneous contemporaneous JJ cord-003571-upogtny6 14 26 medical medical JJ cord-003571-upogtny6 14 27 authorities authority NNS cord-003571-upogtny6 14 28 put put VBD cord-003571-upogtny6 14 29 commendable commendable JJ cord-003571-upogtny6 14 30 effort effort NN cord-003571-upogtny6 14 31 into into IN cord-003571-upogtny6 14 32 reporting report VBG cord-003571-upogtny6 14 33 detailed detailed JJ cord-003571-upogtny6 14 34 epidemiologic epidemiologic JJ cord-003571-upogtny6 14 35 data datum NNS cord-003571-upogtny6 14 36 on on IN cord-003571-upogtny6 14 37 the the DT cord-003571-upogtny6 14 38 progression progression NN cord-003571-upogtny6 14 39 of of IN cord-003571-upogtny6 14 40 the the DT cord-003571-upogtny6 14 41 pandemic pandemic NN cord-003571-upogtny6 14 42 that that WDT cord-003571-upogtny6 14 43 ranged range VBD cord-003571-upogtny6 14 44 from from IN cord-003571-upogtny6 14 45 individual individual JJ cord-003571-upogtny6 14 46 - - HYPH cord-003571-upogtny6 14 47 level level NN cord-003571-upogtny6 14 48 clinical clinical JJ cord-003571-upogtny6 14 49 records record NNS cord-003571-upogtny6 14 50 to to IN cord-003571-upogtny6 14 51 aggregated aggregate VBN cord-003571-upogtny6 14 52 city city NN cord-003571-upogtny6 14 53 - - HYPH cord-003571-upogtny6 14 54 level level NN cord-003571-upogtny6 14 55 vital vital JJ cord-003571-upogtny6 14 56 statistics statistic NNS cord-003571-upogtny6 14 57 ( ( -LRB- cord-003571-upogtny6 14 58 2 2 CD cord-003571-upogtny6 14 59 , , , cord-003571-upogtny6 14 60 3 3 CD cord-003571-upogtny6 14 61 ) ) -RRB- cord-003571-upogtny6 14 62 . . . cord-003571-upogtny6 15 1 In in IN cord-003571-upogtny6 15 2 addition addition NN cord-003571-upogtny6 15 3 to to IN cord-003571-upogtny6 15 4 quantitative quantitative JJ cord-003571-upogtny6 15 5 epidemiologic epidemiologic JJ cord-003571-upogtny6 15 6 data datum NNS cord-003571-upogtny6 15 7 , , , cord-003571-upogtny6 15 8 there there EX cord-003571-upogtny6 15 9 exist exist VBP cord-003571-upogtny6 15 10 many many JJ cord-003571-upogtny6 15 11 anecdotal anecdotal JJ cord-003571-upogtny6 15 12 reports report NNS cord-003571-upogtny6 15 13 from from IN cord-003571-upogtny6 15 14 clinicians clinician NNS cord-003571-upogtny6 15 15 , , , cord-003571-upogtny6 15 16 particularly particularly RB cord-003571-upogtny6 15 17 those those DT cord-003571-upogtny6 15 18 who who WP cord-003571-upogtny6 15 19 served serve VBD cord-003571-upogtny6 15 20 military military JJ cord-003571-upogtny6 15 21 populations population NNS cord-003571-upogtny6 15 22 , , , cord-003571-upogtny6 15 23 that that WDT cord-003571-upogtny6 15 24 have have VBP cord-003571-upogtny6 15 25 been be VBN cord-003571-upogtny6 15 26 mined mine VBN cord-003571-upogtny6 15 27 to to TO cord-003571-upogtny6 15 28 provide provide VB cord-003571-upogtny6 15 29 modern modern JJ cord-003571-upogtny6 15 30 audiences audience NNS cord-003571-upogtny6 15 31 a a DT cord-003571-upogtny6 15 32 comprehensive comprehensive JJ cord-003571-upogtny6 15 33 account account NN cord-003571-upogtny6 15 34 of of IN cord-003571-upogtny6 15 35 the the DT cord-003571-upogtny6 15 36 pandemic pandemic NN cord-003571-upogtny6 15 37 ( ( -LRB- cord-003571-upogtny6 15 38 4 4 CD cord-003571-upogtny6 15 39 ) ) -RRB- cord-003571-upogtny6 15 40 . . . cord-003571-upogtny6 16 1 Yet yet RB cord-003571-upogtny6 16 2 , , , cord-003571-upogtny6 16 3 many many JJ cord-003571-upogtny6 16 4 important important JJ cord-003571-upogtny6 16 5 questions question NNS cord-003571-upogtny6 16 6 remain remain VBP cord-003571-upogtny6 16 7 about about IN cord-003571-upogtny6 16 8 the the DT cord-003571-upogtny6 16 9 evolutionary evolutionary JJ cord-003571-upogtny6 16 10 origins origin NNS cord-003571-upogtny6 16 11 of of IN cord-003571-upogtny6 16 12 the the DT cord-003571-upogtny6 16 13 pandemic pandemic NN cord-003571-upogtny6 16 14 virus virus NN cord-003571-upogtny6 16 15 ; ; : cord-003571-upogtny6 16 16 the the DT cord-003571-upogtny6 16 17 contribution contribution NN cord-003571-upogtny6 16 18 of of IN cord-003571-upogtny6 16 19 World World NNP cord-003571-upogtny6 16 20 War War NNP cord-003571-upogtny6 16 21 I I NNP cord-003571-upogtny6 16 22 and and CC cord-003571-upogtny6 16 23 troop troop NN cord-003571-upogtny6 16 24 displacements displacement NNS cord-003571-upogtny6 16 25 to to IN cord-003571-upogtny6 16 26 pandemic pandemic JJ cord-003571-upogtny6 16 27 emergence emergence NN cord-003571-upogtny6 16 28 and and CC cord-003571-upogtny6 16 29 progression progression NN cord-003571-upogtny6 16 30 ; ; : cord-003571-upogtny6 16 31 the the DT cord-003571-upogtny6 16 32 unique unique JJ cord-003571-upogtny6 16 33 age age NN cord-003571-upogtny6 16 34 profile profile NN cord-003571-upogtny6 16 35 of of IN cord-003571-upogtny6 16 36 pandemic pandemic JJ cord-003571-upogtny6 16 37 deaths death NNS cord-003571-upogtny6 16 38 , , , cord-003571-upogtny6 16 39 with with IN cord-003571-upogtny6 16 40 its -PRON- PRP$ cord-003571-upogtny6 16 41 signature signature NN cord-003571-upogtny6 16 42 of of IN cord-003571-upogtny6 16 43 high high JJ cord-003571-upogtny6 16 44 mortality mortality NN cord-003571-upogtny6 16 45 rate rate NN cord-003571-upogtny6 16 46 among among IN cord-003571-upogtny6 16 47 healthy healthy JJ cord-003571-upogtny6 16 48 young young JJ cord-003571-upogtny6 16 49 adults adult NNS cord-003571-upogtny6 16 50 ; ; : cord-003571-upogtny6 16 51 the the DT cord-003571-upogtny6 16 52 consequences consequence NNS cord-003571-upogtny6 16 53 of of IN cord-003571-upogtny6 16 54 such such PDT cord-003571-upogtny6 16 55 a a DT cord-003571-upogtny6 16 56 large large JJ cord-003571-upogtny6 16 57 mortality mortality NN cord-003571-upogtny6 16 58 event event NN cord-003571-upogtny6 16 59 on on IN cord-003571-upogtny6 16 60 natality natality NN cord-003571-upogtny6 16 61 ; ; : cord-003571-upogtny6 16 62 and and CC cord-003571-upogtny6 16 63 the the DT cord-003571-upogtny6 16 64 heterogeneity heterogeneity NN cord-003571-upogtny6 16 65 of of IN cord-003571-upogtny6 16 66 the the DT cord-003571-upogtny6 16 67 pandemic pandemic NN cord-003571-upogtny6 16 68 experience experience NN cord-003571-upogtny6 16 69 around around IN cord-003571-upogtny6 16 70 the the DT cord-003571-upogtny6 16 71 world world NN cord-003571-upogtny6 16 72 . . . cord-003571-upogtny6 17 1 Such such JJ cord-003571-upogtny6 17 2 mysteries mystery NNS cord-003571-upogtny6 17 3 have have VBP cord-003571-upogtny6 17 4 captured capture VBN cord-003571-upogtny6 17 5 the the DT cord-003571-upogtny6 17 6 attention attention NN cord-003571-upogtny6 17 7 of of IN cord-003571-upogtny6 17 8 the the DT cord-003571-upogtny6 17 9 lay lay NN cord-003571-upogtny6 17 10 public public JJ cord-003571-upogtny6 17 11 and and CC cord-003571-upogtny6 17 12 scientific scientific JJ cord-003571-upogtny6 17 13 community community NN cord-003571-upogtny6 17 14 alike alike RB cord-003571-upogtny6 17 15 . . . cord-003571-upogtny6 18 1 In in IN cord-003571-upogtny6 18 2 commemoration commemoration NN cord-003571-upogtny6 18 3 of of IN cord-003571-upogtny6 18 4 the the DT cord-003571-upogtny6 18 5 centennial centennial NN cord-003571-upogtny6 18 6 of of IN cord-003571-upogtny6 18 7 the the DT cord-003571-upogtny6 18 8 1918 1918 CD cord-003571-upogtny6 18 9 pandemic pandemic NN cord-003571-upogtny6 18 10 , , , cord-003571-upogtny6 18 11 the the DT cord-003571-upogtny6 18 12 American American NNP cord-003571-upogtny6 18 13 Journal Journal NNP cord-003571-upogtny6 18 14 of of IN cord-003571-upogtny6 18 15 Epidemiology Epidemiology NNP cord-003571-upogtny6 18 16 has have VBZ cord-003571-upogtny6 18 17 convened convene VBN cord-003571-upogtny6 18 18 a a DT cord-003571-upogtny6 18 19 collection collection NN cord-003571-upogtny6 18 20 of of IN cord-003571-upogtny6 18 21 12 12 CD cord-003571-upogtny6 18 22 articles article NNS cord-003571-upogtny6 18 23 that that WDT cord-003571-upogtny6 18 24 further further RB cord-003571-upogtny6 18 25 illuminate illuminate VBP cord-003571-upogtny6 18 26 the the DT cord-003571-upogtny6 18 27 epidemiology epidemiology NN cord-003571-upogtny6 18 28 of of IN cord-003571-upogtny6 18 29 that that DT cord-003571-upogtny6 18 30 pandemic pandemic NN cord-003571-upogtny6 18 31 and and CC cord-003571-upogtny6 18 32 consider consider VB cord-003571-upogtny6 18 33 whether whether IN cord-003571-upogtny6 18 34 we -PRON- PRP cord-003571-upogtny6 18 35 would would MD cord-003571-upogtny6 18 36 be be VB cord-003571-upogtny6 18 37 more more RBR cord-003571-upogtny6 18 38 prepared prepared JJ cord-003571-upogtny6 18 39 if if IN cord-003571-upogtny6 18 40 an an DT cord-003571-upogtny6 18 41 equally equally RB cord-003571-upogtny6 18 42 deadly deadly JJ cord-003571-upogtny6 18 43 influenza influenza NN cord-003571-upogtny6 18 44 virus virus NN cord-003571-upogtny6 18 45 were be VBD cord-003571-upogtny6 18 46 to to TO cord-003571-upogtny6 18 47 emerge emerge VB cord-003571-upogtny6 18 48 today today NN cord-003571-upogtny6 18 49 . . . cord-003571-upogtny6 19 1 Five five CD cord-003571-upogtny6 19 2 of of IN cord-003571-upogtny6 19 3 the the DT cord-003571-upogtny6 19 4 12 12 CD cord-003571-upogtny6 19 5 articles article NNS cord-003571-upogtny6 19 6 touch touch NN cord-003571-upogtny6 19 7 on on IN cord-003571-upogtny6 19 8 the the DT cord-003571-upogtny6 19 9 origins origin NNS cord-003571-upogtny6 19 10 of of IN cord-003571-upogtny6 19 11 the the DT cord-003571-upogtny6 19 12 1918 1918 CD cord-003571-upogtny6 19 13 pandemic pandemic NNP cord-003571-upogtny6 19 14 virus virus NN cord-003571-upogtny6 19 15 , , , cord-003571-upogtny6 19 16 addressing address VBG cord-003571-upogtny6 19 17 the the DT cord-003571-upogtny6 19 18 role role NN cord-003571-upogtny6 19 19 of of IN cord-003571-upogtny6 19 20 swine swine NN cord-003571-upogtny6 19 21 as as IN cord-003571-upogtny6 19 22 mixing mix VBG cord-003571-upogtny6 19 23 vessels vessel NNS cord-003571-upogtny6 19 24 in in IN cord-003571-upogtny6 19 25 this this DT cord-003571-upogtny6 19 26 and and CC cord-003571-upogtny6 19 27 other other JJ cord-003571-upogtny6 19 28 pandemic pandemic NN cord-003571-upogtny6 19 29 events event NNS cord-003571-upogtny6 19 30 ( ( -LRB- cord-003571-upogtny6 19 31 5 5 CD cord-003571-upogtny6 19 32 ) ) -RRB- cord-003571-upogtny6 19 33 , , , cord-003571-upogtny6 19 34 the the DT cord-003571-upogtny6 19 35 age age NN cord-003571-upogtny6 19 36 - - HYPH cord-003571-upogtny6 19 37 specific specific JJ cord-003571-upogtny6 19 38 mortality mortality NN cord-003571-upogtny6 19 39 patterns pattern NNS cord-003571-upogtny6 19 40 of of IN cord-003571-upogtny6 19 41 the the DT cord-003571-upogtny6 19 42 pandemic pandemic NN cord-003571-upogtny6 19 43 ( ( -LRB- cord-003571-upogtny6 19 44 6 6 CD cord-003571-upogtny6 19 45 ) ) -RRB- cord-003571-upogtny6 19 46 ( ( -LRB- cord-003571-upogtny6 19 47 7 7 LS cord-003571-upogtny6 19 48 ) ) -RRB- cord-003571-upogtny6 19 49 ( ( -LRB- cord-003571-upogtny6 19 50 8) 8) NNP cord-003571-upogtny6 19 51 , , , cord-003571-upogtny6 19 52 and and CC cord-003571-upogtny6 19 53 prior prior JJ cord-003571-upogtny6 19 54 population population NN cord-003571-upogtny6 19 55 immunity immunity NN cord-003571-upogtny6 19 56 ( ( -LRB- cord-003571-upogtny6 19 57 9 9 CD cord-003571-upogtny6 19 58 ) ) -RRB- cord-003571-upogtny6 19 59 . . . cord-003571-upogtny6 20 1 Others other NNS cord-003571-upogtny6 20 2 include include VBP cord-003571-upogtny6 20 3 reports report NNS cord-003571-upogtny6 20 4 on on IN cord-003571-upogtny6 20 5 geographic geographic JJ cord-003571-upogtny6 20 6 and and CC cord-003571-upogtny6 20 7 social social JJ cord-003571-upogtny6 20 8 heterogeneities heterogeneity NNS cord-003571-upogtny6 20 9 in in IN cord-003571-upogtny6 20 10 the the DT cord-003571-upogtny6 20 11 pandemic pandemic NN cord-003571-upogtny6 20 12 experience experience NN cord-003571-upogtny6 20 13 in in IN cord-003571-upogtny6 20 14 which which WDT cord-003571-upogtny6 20 15 the the DT cord-003571-upogtny6 20 16 authors author NNS cord-003571-upogtny6 20 17 describe describe VBP cord-003571-upogtny6 20 18 the the DT cord-003571-upogtny6 20 19 spatial spatial JJ cord-003571-upogtny6 20 20 diffusion diffusion NN cord-003571-upogtny6 20 21 of of IN cord-003571-upogtny6 20 22 the the DT cord-003571-upogtny6 20 23 pandemic pandemic NN cord-003571-upogtny6 20 24 in in IN cord-003571-upogtny6 20 25 India India NNP cord-003571-upogtny6 20 26 and and CC cord-003571-upogtny6 20 27 Portugal Portugal NNP cord-003571-upogtny6 20 28 ( ( -LRB- cord-003571-upogtny6 20 29 10 10 CD cord-003571-upogtny6 20 30 , , , cord-003571-upogtny6 20 31 11 11 CD cord-003571-upogtny6 20 32 ) ) -RRB- cord-003571-upogtny6 20 33 , , , cord-003571-upogtny6 20 34 the the DT cord-003571-upogtny6 20 35 socioeconomic socioeconomic JJ cord-003571-upogtny6 20 36 predictors predictor NNS cord-003571-upogtny6 20 37 of of IN cord-003571-upogtny6 20 38 high high JJ cord-003571-upogtny6 20 39 mortality mortality NN cord-003571-upogtny6 20 40 risk risk NN cord-003571-upogtny6 20 41 in in IN cord-003571-upogtny6 20 42 Sweden Sweden NNP cord-003571-upogtny6 20 43 and and CC cord-003571-upogtny6 20 44 globally globally RB cord-003571-upogtny6 20 45 ( ( -LRB- cord-003571-upogtny6 20 46 12 12 CD cord-003571-upogtny6 20 47 , , , cord-003571-upogtny6 20 48 13 13 CD cord-003571-upogtny6 20 49 ) ) -RRB- cord-003571-upogtny6 20 50 , , , cord-003571-upogtny6 20 51 and and CC cord-003571-upogtny6 20 52 the the DT cord-003571-upogtny6 20 53 consequences consequence NNS cord-003571-upogtny6 20 54 of of IN cord-003571-upogtny6 20 55 the the DT cord-003571-upogtny6 20 56 pandemic pandemic NN cord-003571-upogtny6 20 57 on on IN cord-003571-upogtny6 20 58 US US NNP cord-003571-upogtny6 20 59 natality natality NN cord-003571-upogtny6 20 60 rates rate NNS cord-003571-upogtny6 20 61 ( ( -LRB- cord-003571-upogtny6 20 62 14 14 CD cord-003571-upogtny6 20 63 , , , cord-003571-upogtny6 20 64 15 15 CD cord-003571-upogtny6 20 65 ) ) -RRB- cord-003571-upogtny6 20 66 . . . cord-003571-upogtny6 21 1 Finally finally RB cord-003571-upogtny6 21 2 , , , cord-003571-upogtny6 21 3 2 2 CD cord-003571-upogtny6 21 4 commentaries commentary NNS cord-003571-upogtny6 21 5 address address VBP cord-003571-upogtny6 21 6 preparedness preparedness NN cord-003571-upogtny6 21 7 for for IN cord-003571-upogtny6 21 8 future future JJ cord-003571-upogtny6 21 9 influenza influenza NN cord-003571-upogtny6 21 10 pandemics pandemic NNS cord-003571-upogtny6 21 11 ( ( -LRB- cord-003571-upogtny6 21 12 16 16 CD cord-003571-upogtny6 21 13 , , , cord-003571-upogtny6 21 14 17 17 CD cord-003571-upogtny6 21 15 ) ) -RRB- cord-003571-upogtny6 21 16 . . . cord-003571-upogtny6 22 1 The the DT cord-003571-upogtny6 22 2 influenza influenza NN cord-003571-upogtny6 22 3 virus virus NN cord-003571-upogtny6 22 4 is be VBZ cord-003571-upogtny6 22 5 remarkable remarkable JJ cord-003571-upogtny6 22 6 for for IN cord-003571-upogtny6 22 7 its -PRON- PRP$ cord-003571-upogtny6 22 8 ability ability NN cord-003571-upogtny6 22 9 to to TO cord-003571-upogtny6 22 10 infect infect VB cord-003571-upogtny6 22 11 a a DT cord-003571-upogtny6 22 12 variety variety NN cord-003571-upogtny6 22 13 of of IN cord-003571-upogtny6 22 14 animal animal NN cord-003571-upogtny6 22 15 species specie NNS cord-003571-upogtny6 22 16 , , , cord-003571-upogtny6 22 17 from from IN cord-003571-upogtny6 22 18 bats bat NNS cord-003571-upogtny6 22 19 to to IN cord-003571-upogtny6 22 20 birds bird NNS cord-003571-upogtny6 22 21 to to IN cord-003571-upogtny6 22 22 mammals mammal NNS cord-003571-upogtny6 22 23 . . . cord-003571-upogtny6 23 1 Although although IN cord-003571-upogtny6 23 2 successful successful JJ cord-003571-upogtny6 23 3 cross cross JJ cord-003571-upogtny6 23 4 - - JJ cord-003571-upogtny6 23 5 species species JJ cord-003571-upogtny6 23 6 transmission transmission NN cord-003571-upogtny6 23 7 events event NNS cord-003571-upogtny6 23 8 may may MD cord-003571-upogtny6 23 9 be be VB cord-003571-upogtny6 23 10 rare rare JJ cord-003571-upogtny6 23 11 , , , cord-003571-upogtny6 23 12 they -PRON- PRP cord-003571-upogtny6 23 13 play play VBP cord-003571-upogtny6 23 14 a a DT cord-003571-upogtny6 23 15 key key JJ cord-003571-upogtny6 23 16 role role NN cord-003571-upogtny6 23 17 in in IN cord-003571-upogtny6 23 18 the the DT cord-003571-upogtny6 23 19 genesis genesis NN cord-003571-upogtny6 23 20 of of IN cord-003571-upogtny6 23 21 new new JJ cord-003571-upogtny6 23 22 pandemic pandemic NN cord-003571-upogtny6 23 23 strains strain NNS cord-003571-upogtny6 23 24 . . . cord-003571-upogtny6 24 1 Nelson Nelson NNP cord-003571-upogtny6 24 2 and and CC cord-003571-upogtny6 24 3 Worobey Worobey NNP cord-003571-upogtny6 24 4 ( ( -LRB- cord-003571-upogtny6 24 5 5 5 CD cord-003571-upogtny6 24 6 ) ) -RRB- cord-003571-upogtny6 24 7 discussed discuss VBD cord-003571-upogtny6 24 8 different different JJ cord-003571-upogtny6 24 9 lines line NNS cord-003571-upogtny6 24 10 of of IN cord-003571-upogtny6 24 11 evidence evidence NN cord-003571-upogtny6 24 12 informing inform VBG cord-003571-upogtny6 24 13 the the DT cord-003571-upogtny6 24 14 origins origin NNS cord-003571-upogtny6 24 15 of of IN cord-003571-upogtny6 24 16 the the DT cord-003571-upogtny6 24 17 1918 1918 CD cord-003571-upogtny6 24 18 virus virus NN cord-003571-upogtny6 24 19 , , , cord-003571-upogtny6 24 20 including include VBG cord-003571-upogtny6 24 21 the the DT cord-003571-upogtny6 24 22 genetic genetic JJ cord-003571-upogtny6 24 23 make make NN cord-003571-upogtny6 24 24 - - HYPH cord-003571-upogtny6 24 25 up up NN cord-003571-upogtny6 24 26 of of IN cord-003571-upogtny6 24 27 the the DT cord-003571-upogtny6 24 28 1918 1918 CD cord-003571-upogtny6 24 29 virus virus NN cord-003571-upogtny6 24 30 and and CC cord-003571-upogtny6 24 31 other other JJ cord-003571-upogtny6 24 32 pandemic pandemic NN cord-003571-upogtny6 24 33 strains strain NNS cord-003571-upogtny6 24 34 , , , cord-003571-upogtny6 24 35 the the DT cord-003571-upogtny6 24 36 characteristics characteristic NNS cord-003571-upogtny6 24 37 of of IN cord-003571-upogtny6 24 38 influenza influenza NN cord-003571-upogtny6 24 39 receptors receptor NNS cord-003571-upogtny6 24 40 across across IN cord-003571-upogtny6 24 41 different different JJ cord-003571-upogtny6 24 42 influenza influenza NN cord-003571-upogtny6 24 43 hosts host NNS cord-003571-upogtny6 24 44 , , , cord-003571-upogtny6 24 45 and and CC cord-003571-upogtny6 24 46 the the DT cord-003571-upogtny6 24 47 frequency frequency NN cord-003571-upogtny6 24 48 of of IN cord-003571-upogtny6 24 49 cross cross JJ cord-003571-upogtny6 24 50 - - JJ cord-003571-upogtny6 24 51 species species JJ cord-003571-upogtny6 24 52 transmission transmission NN cord-003571-upogtny6 24 53 events event NNS cord-003571-upogtny6 24 54 . . . cord-003571-upogtny6 25 1 They -PRON- PRP cord-003571-upogtny6 25 2 concluded conclude VBD cord-003571-upogtny6 25 3 that that IN cord-003571-upogtny6 25 4 the the DT cord-003571-upogtny6 25 5 pandemic pandemic NN cord-003571-upogtny6 25 6 virus virus NN cord-003571-upogtny6 25 7 must must MD cord-003571-upogtny6 25 8 have have VB cord-003571-upogtny6 25 9 emerged emerge VBN cord-003571-upogtny6 25 10 in in IN cord-003571-upogtny6 25 11 mammals mammal NNS cord-003571-upogtny6 25 12 just just RB cord-003571-upogtny6 25 13 before before IN cord-003571-upogtny6 25 14 1918 1918 CD cord-003571-upogtny6 25 15 , , , cord-003571-upogtny6 25 16 most most RBS cord-003571-upogtny6 25 17 likely likely JJ cord-003571-upogtny6 25 18 from from IN cord-003571-upogtny6 25 19 the the DT cord-003571-upogtny6 25 20 avian avian JJ cord-003571-upogtny6 25 21 reservoir reservoir NN cord-003571-upogtny6 25 22 , , , cord-003571-upogtny6 25 23 with with IN cord-003571-upogtny6 25 24 onward onward JJ cord-003571-upogtny6 25 25 transmission transmission NN cord-003571-upogtny6 25 26 from from IN cord-003571-upogtny6 25 27 humans human NNS cord-003571-upogtny6 25 28 to to IN cord-003571-upogtny6 25 29 swine swine NN cord-003571-upogtny6 25 30 . . . cord-003571-upogtny6 26 1 More more RBR cord-003571-upogtny6 26 2 broadly broadly RB cord-003571-upogtny6 26 3 , , , cord-003571-upogtny6 26 4 a a DT cord-003571-upogtny6 26 5 re re NN cord-003571-upogtny6 26 6 - - NN cord-003571-upogtny6 26 7 analysis analysis NN cord-003571-upogtny6 26 8 of of IN cord-003571-upogtny6 26 9 virologic virologic NNP cord-003571-upogtny6 26 10 data datum NNS cord-003571-upogtny6 26 11 from from IN cord-003571-upogtny6 26 12 the the DT cord-003571-upogtny6 26 13 1957 1957 CD cord-003571-upogtny6 26 14 and and CC cord-003571-upogtny6 26 15 1968 1968 CD cord-003571-upogtny6 26 16 pandemics pandemic NNS cord-003571-upogtny6 26 17 , , , cord-003571-upogtny6 26 18 together together RB cord-003571-upogtny6 26 19 with with IN cord-003571-upogtny6 26 20 a a DT cord-003571-upogtny6 26 21 modern modern JJ cord-003571-upogtny6 26 22 understanding understanding NN cord-003571-upogtny6 26 23 of of IN cord-003571-upogtny6 26 24 the the DT cord-003571-upogtny6 26 25 swinehuman swinehuman NNP cord-003571-upogtny6 26 26 interface interface NNP cord-003571-upogtny6 26 27 , , , cord-003571-upogtny6 26 28 suggested suggest VBD cord-003571-upogtny6 26 29 a a DT cord-003571-upogtny6 26 30 twist twist NN cord-003571-upogtny6 26 31 on on IN cord-003571-upogtny6 26 32 the the DT cord-003571-upogtny6 26 33 long long RB cord-003571-upogtny6 26 34 - - HYPH cord-003571-upogtny6 26 35 standing stand VBG cord-003571-upogtny6 26 36 concept concept NN cord-003571-upogtny6 26 37 of of IN cord-003571-upogtny6 26 38 swine swine NN cord-003571-upogtny6 26 39 as as IN cord-003571-upogtny6 26 40 a a DT cord-003571-upogtny6 26 41 " " `` cord-003571-upogtny6 26 42 mixing mix VBG cord-003571-upogtny6 26 43 vessel vessel NN cord-003571-upogtny6 26 44 " " '' cord-003571-upogtny6 26 45 for for IN cord-003571-upogtny6 26 46 influenza influenza NN cord-003571-upogtny6 26 47 virus virus NN cord-003571-upogtny6 26 48 . . . cord-003571-upogtny6 27 1 The the DT cord-003571-upogtny6 27 2 authors author NNS cord-003571-upogtny6 27 3 proposed propose VBD cord-003571-upogtny6 27 4 that that IN cord-003571-upogtny6 27 5 swine swine NN cord-003571-upogtny6 27 6 should should MD cord-003571-upogtny6 27 7 be be VB cord-003571-upogtny6 27 8 viewed view VBN cord-003571-upogtny6 27 9 as as IN cord-003571-upogtny6 27 10 a a DT cord-003571-upogtny6 27 11 repository repository NN cord-003571-upogtny6 27 12 of of IN cord-003571-upogtny6 27 13 historic historic JJ cord-003571-upogtny6 27 14 human human JJ cord-003571-upogtny6 27 15 viruses virus NNS cord-003571-upogtny6 27 16 rather rather RB cord-003571-upogtny6 27 17 than than IN cord-003571-upogtny6 27 18 a a DT cord-003571-upogtny6 27 19 conduit conduit NN cord-003571-upogtny6 27 20 for for IN cord-003571-upogtny6 27 21 reassortment reassortment NN cord-003571-upogtny6 27 22 of of IN cord-003571-upogtny6 27 23 genetic genetic JJ cord-003571-upogtny6 27 24 material material NN cord-003571-upogtny6 27 25 between between IN cord-003571-upogtny6 27 26 avian avian JJ cord-003571-upogtny6 27 27 and and CC cord-003571-upogtny6 27 28 human human JJ cord-003571-upogtny6 27 29 viruses virus NNS cord-003571-upogtny6 27 30 . . . cord-003571-upogtny6 28 1 Van Van NNP cord-003571-upogtny6 28 2 Wijhe Wijhe NNP cord-003571-upogtny6 28 3 et et NNP cord-003571-upogtny6 28 4 al al NNP cord-003571-upogtny6 28 5 . . . cord-003571-upogtny6 29 1 ( ( -LRB- cord-003571-upogtny6 29 2 6 6 LS cord-003571-upogtny6 29 3 ) ) -RRB- cord-003571-upogtny6 29 4 returned return VBD cord-003571-upogtny6 29 5 to to IN cord-003571-upogtny6 29 6 the the DT cord-003571-upogtny6 29 7 question question NN cord-003571-upogtny6 29 8 of of IN cord-003571-upogtny6 29 9 the the DT cord-003571-upogtny6 29 10 origins origin NNS cord-003571-upogtny6 29 11 of of IN cord-003571-upogtny6 29 12 the the DT cord-003571-upogtny6 29 13 1918 1918 CD cord-003571-upogtny6 29 14 virus virus NN cord-003571-upogtny6 29 15 by by IN cord-003571-upogtny6 29 16 exploring explore VBG cord-003571-upogtny6 29 17 the the DT cord-003571-upogtny6 29 18 epidemiologic epidemiologic JJ cord-003571-upogtny6 29 19 imprint imprint NN cord-003571-upogtny6 29 20 of of IN cord-003571-upogtny6 29 21 the the DT cord-003571-upogtny6 29 22 1918 1918 CD cord-003571-upogtny6 29 23 virus virus NN cord-003571-upogtny6 29 24 on on IN cord-003571-upogtny6 29 25 Danish danish JJ cord-003571-upogtny6 29 26 mortality mortality NN cord-003571-upogtny6 29 27 records record NNS cord-003571-upogtny6 29 28 , , , cord-003571-upogtny6 29 29 echoing echo VBG cord-003571-upogtny6 29 30 recent recent JJ cord-003571-upogtny6 29 31 work work NN cord-003571-upogtny6 29 32 on on IN cord-003571-upogtny6 29 33 immune immune JJ cord-003571-upogtny6 29 34 imprinting imprinting NN cord-003571-upogtny6 29 35 ( ( -LRB- cord-003571-upogtny6 29 36 18 18 CD cord-003571-upogtny6 29 37 ) ) -RRB- cord-003571-upogtny6 29 38 ( ( -LRB- cord-003571-upogtny6 29 39 19 19 CD cord-003571-upogtny6 29 40 ) ) -RRB- cord-003571-upogtny6 29 41 ( ( -LRB- cord-003571-upogtny6 29 42 20 20 CD cord-003571-upogtny6 29 43 ) ) -RRB- cord-003571-upogtny6 29 44 . . . cord-003571-upogtny6 30 1 They -PRON- PRP cord-003571-upogtny6 30 2 identified identify VBD cord-003571-upogtny6 30 3 several several JJ cord-003571-upogtny6 30 4 age age NN cord-003571-upogtny6 30 5 breakpoints breakpoint NNS cord-003571-upogtny6 30 6 in in IN cord-003571-upogtny6 30 7 pandemic pandemic NN cord-003571-upogtny6 30 8 mortality mortality NN cord-003571-upogtny6 30 9 that that WDT cord-003571-upogtny6 30 10 were be VBD cord-003571-upogtny6 30 11 suggestive suggestive JJ cord-003571-upogtny6 30 12 of of IN cord-003571-upogtny6 30 13 the the DT cord-003571-upogtny6 30 14 cycling cycling NN cord-003571-upogtny6 30 15 of of IN cord-003571-upogtny6 30 16 different different JJ cord-003571-upogtny6 30 17 influenza influenza NN cord-003571-upogtny6 30 18 strains strain NNS cord-003571-upogtny6 30 19 between between IN cord-003571-upogtny6 30 20 the the DT cord-003571-upogtny6 30 21 mid-19th mid-19th NN cord-003571-upogtny6 30 22 century century NN cord-003571-upogtny6 30 23 and and CC cord-003571-upogtny6 30 24 the the DT cord-003571-upogtny6 30 25 1918 1918 CD cord-003571-upogtny6 30 26 pandemic pandemic NN cord-003571-upogtny6 30 27 . . . cord-003571-upogtny6 31 1 Most most RBS cord-003571-upogtny6 31 2 notably notably RB cord-003571-upogtny6 31 3 , , , cord-003571-upogtny6 31 4 they -PRON- PRP cord-003571-upogtny6 31 5 argued argue VBD cord-003571-upogtny6 31 6 for for IN cord-003571-upogtny6 31 7 co co NN cord-003571-upogtny6 31 8 - - NN cord-003571-upogtny6 31 9 circulation circulation NN cord-003571-upogtny6 31 10 of of IN cord-003571-upogtny6 31 11 2 2 CD cord-003571-upogtny6 31 12 subtypes subtype NNS cord-003571-upogtny6 31 13 of of IN cord-003571-upogtny6 31 14 influenza influenza NN cord-003571-upogtny6 31 15 virus virus NN cord-003571-upogtny6 31 16 ( ( -LRB- cord-003571-upogtny6 31 17 carrying carry VBG cord-003571-upogtny6 31 18 type type NN cord-003571-upogtny6 31 19 I I NNP cord-003571-upogtny6 31 20 and and CC cord-003571-upogtny6 31 21 II II NNP cord-003571-upogtny6 31 22 hemagglutinin hemagglutinin NN cord-003571-upogtny6 31 23 surface surface NN cord-003571-upogtny6 31 24 antigens antigen NNS cord-003571-upogtny6 31 25 ) ) -RRB- cord-003571-upogtny6 31 26 between between IN cord-003571-upogtny6 31 27 1873 1873 CD cord-003571-upogtny6 31 28 and and CC cord-003571-upogtny6 31 29 1908 1908 CD cord-003571-upogtny6 31 30 . . . cord-003571-upogtny6 32 1 As as IN cord-003571-upogtny6 32 2 a a DT cord-003571-upogtny6 32 3 result result NN cord-003571-upogtny6 32 4 , , , cord-003571-upogtny6 32 5 persons person NNS cord-003571-upogtny6 32 6 born bear VBN cord-003571-upogtny6 32 7 between between IN cord-003571-upogtny6 32 8 1873 1873 CD cord-003571-upogtny6 32 9 and and CC cord-003571-upogtny6 32 10 1908 1908 CD cord-003571-upogtny6 32 11 ( ( -LRB- cord-003571-upogtny6 32 12 aged age VBN cord-003571-upogtny6 32 13 10 10 CD cord-003571-upogtny6 32 14 - - SYM cord-003571-upogtny6 32 15 45 45 CD cord-003571-upogtny6 32 16 years year NNS cord-003571-upogtny6 32 17 during during IN cord-003571-upogtny6 32 18 the the DT cord-003571-upogtny6 32 19 1918 1918 CD cord-003571-upogtny6 32 20 pandemic pandemic NN cord-003571-upogtny6 32 21 ) ) -RRB- cord-003571-upogtny6 32 22 may may MD cord-003571-upogtny6 32 23 have have VB cord-003571-upogtny6 32 24 been be VBN cord-003571-upogtny6 32 25 primed prime VBN cord-003571-upogtny6 32 26 by by IN cord-003571-upogtny6 32 27 either either DT cord-003571-upogtny6 32 28 hemagglutinin hemagglutinin NN cord-003571-upogtny6 32 29 type type NN cord-003571-upogtny6 32 30 , , , cord-003571-upogtny6 32 31 potentially potentially RB cord-003571-upogtny6 32 32 explaining explain VBG cord-003571-upogtny6 32 33 the the DT cord-003571-upogtny6 32 34 intriguing intriguing JJ cord-003571-upogtny6 32 35 age age NN cord-003571-upogtny6 32 36 profile profile NN cord-003571-upogtny6 32 37 of of IN cord-003571-upogtny6 32 38 pandemic pandemic JJ cord-003571-upogtny6 32 39 mortality mortality NN cord-003571-upogtny6 32 40 in in IN cord-003571-upogtny6 32 41 adults adult NNS cord-003571-upogtny6 32 42 . . . cord-003571-upogtny6 33 1 Cilek Cilek NNP cord-003571-upogtny6 33 2 et et FW cord-003571-upogtny6 33 3 al al NNP cord-003571-upogtny6 33 4 . . . cord-003571-upogtny6 34 1 ( ( -LRB- cord-003571-upogtny6 34 2 7 7 CD cord-003571-upogtny6 34 3 ) ) -RRB- cord-003571-upogtny6 34 4 used use VBD cord-003571-upogtny6 34 5 a a DT cord-003571-upogtny6 34 6 similar similar JJ cord-003571-upogtny6 34 7 epidemiologic epidemiologic JJ cord-003571-upogtny6 34 8 approach approach NN cord-003571-upogtny6 34 9 to to TO cord-003571-upogtny6 34 10 explore explore VB cord-003571-upogtny6 34 11 the the DT cord-003571-upogtny6 34 12 1918 1918 CD cord-003571-upogtny6 34 13 pandemic pandemic NN cord-003571-upogtny6 34 14 mortality mortality NN cord-003571-upogtny6 34 15 patterns pattern NNS cord-003571-upogtny6 34 16 in in IN cord-003571-upogtny6 34 17 Madrid Madrid NNP cord-003571-upogtny6 34 18 , , , cord-003571-upogtny6 34 19 Spain Spain NNP cord-003571-upogtny6 34 20 . . . cord-003571-upogtny6 35 1 Madrid Madrid NNP cord-003571-upogtny6 35 2 is be VBZ cord-003571-upogtny6 35 3 particularly particularly RB cord-003571-upogtny6 35 4 interesting interesting JJ cord-003571-upogtny6 35 5 because because IN cord-003571-upogtny6 35 6 a a DT cord-003571-upogtny6 35 7 lethal lethal JJ cord-003571-upogtny6 35 8 pandemic pandemic NN cord-003571-upogtny6 35 9 wave wave NN cord-003571-upogtny6 35 10 was be VBD cord-003571-upogtny6 35 11 reported report VBN cord-003571-upogtny6 35 12 in in IN cord-003571-upogtny6 35 13 the the DT cord-003571-upogtny6 35 14 city city NN cord-003571-upogtny6 35 15 in in IN cord-003571-upogtny6 35 16 June June NNP cord-003571-upogtny6 35 17 1918 1918 CD cord-003571-upogtny6 35 18 , , , cord-003571-upogtny6 35 19 the the DT cord-003571-upogtny6 35 20 earliest early JJS cord-003571-upogtny6 35 21 such such JJ cord-003571-upogtny6 35 22 event event NN cord-003571-upogtny6 35 23 recorded record VBN cord-003571-upogtny6 35 24 . . . cord-003571-upogtny6 36 1 Similar similar JJ cord-003571-upogtny6 36 2 to to IN cord-003571-upogtny6 36 3 other other JJ cord-003571-upogtny6 36 4 regions region NNS cord-003571-upogtny6 36 5 of of IN cord-003571-upogtny6 36 6 the the DT cord-003571-upogtny6 36 7 world world NN cord-003571-upogtny6 36 8 , , , cord-003571-upogtny6 36 9 Madrid Madrid NNP cord-003571-upogtny6 36 10 experienced experience VBD cord-003571-upogtny6 36 11 a a DT cord-003571-upogtny6 36 12 signature signature NN cord-003571-upogtny6 36 13 pandemic pandemic NN cord-003571-upogtny6 36 14 pattern pattern NN cord-003571-upogtny6 36 15 of of IN cord-003571-upogtny6 36 16 higher high JJR cord-003571-upogtny6 36 17 mortality mortality NN cord-003571-upogtny6 36 18 rates rate NNS cord-003571-upogtny6 36 19 among among IN cord-003571-upogtny6 36 20 young young JJ cord-003571-upogtny6 36 21 adults adult NNS cord-003571-upogtny6 36 22 . . . cord-003571-upogtny6 37 1 However however RB cord-003571-upogtny6 37 2 , , , cord-003571-upogtny6 37 3 seniors senior NNS cord-003571-upogtny6 37 4 in in IN cord-003571-upogtny6 37 5 Madrid Madrid NNP cord-003571-upogtny6 37 6 suffered suffer VBD cord-003571-upogtny6 37 7 equally equally RB cord-003571-upogtny6 37 8 high high JJ cord-003571-upogtny6 37 9 rates rate NNS cord-003571-upogtny6 37 10 of of IN cord-003571-upogtny6 37 11 excess excess JJ cord-003571-upogtny6 37 12 influenza influenza NN cord-003571-upogtny6 37 13 mortality mortality NN cord-003571-upogtny6 37 14 . . . cord-003571-upogtny6 38 1 This this DT cord-003571-upogtny6 38 2 is be VBZ cord-003571-upogtny6 38 3 unlike unlike IN cord-003571-upogtny6 38 4 the the DT cord-003571-upogtny6 38 5 experience experience NN cord-003571-upogtny6 38 6 of of IN cord-003571-upogtny6 38 7 the the DT cord-003571-upogtny6 38 8 rest rest NN cord-003571-upogtny6 38 9 of of IN cord-003571-upogtny6 38 10 Europe Europe NNP cord-003571-upogtny6 38 11 and and CC cord-003571-upogtny6 38 12 North North NNP cord-003571-upogtny6 38 13 America America NNP cord-003571-upogtny6 38 14 , , , cord-003571-upogtny6 38 15 where where WRB cord-003571-upogtny6 38 16 seniors senior NNS cord-003571-upogtny6 38 17 were be VBD cord-003571-upogtny6 38 18 reportedly reportedly RB cord-003571-upogtny6 38 19 spared spare VBN cord-003571-upogtny6 38 20 , , , cord-003571-upogtny6 38 21 presumably presumably RB cord-003571-upogtny6 38 22 because because IN cord-003571-upogtny6 38 23 of of IN cord-003571-upogtny6 38 24 antigenic antigenic JJ cord-003571-upogtny6 38 25 recycling recycling NN cord-003571-upogtny6 38 26 ( ( -LRB- cord-003571-upogtny6 38 27 i.e. i.e. FW cord-003571-upogtny6 38 28 , , , cord-003571-upogtny6 38 29 exposure exposure NN cord-003571-upogtny6 38 30 to to IN cord-003571-upogtny6 38 31 a a DT cord-003571-upogtny6 38 32 related related JJ cord-003571-upogtny6 38 33 strain strain NN cord-003571-upogtny6 38 34 in in IN cord-003571-upogtny6 38 35 childhood childhood NN cord-003571-upogtny6 38 36 that that WDT cord-003571-upogtny6 38 37 conferred confer VBD cord-003571-upogtny6 38 38 partial partial JJ cord-003571-upogtny6 38 39 protection protection NN cord-003571-upogtny6 38 40 ) ) -RRB- cord-003571-upogtny6 38 41 ( ( -LRB- cord-003571-upogtny6 38 42 20 20 CD cord-003571-upogtny6 38 43 , , , cord-003571-upogtny6 38 44 21 21 CD cord-003571-upogtny6 38 45 ) ) -RRB- cord-003571-upogtny6 38 46 . . . cord-003571-upogtny6 39 1 This this DT cord-003571-upogtny6 39 2 is be VBZ cord-003571-upogtny6 39 3 an an DT cord-003571-upogtny6 39 4 intriguing intriguing JJ cord-003571-upogtny6 39 5 finding finding NN cord-003571-upogtny6 39 6 , , , cord-003571-upogtny6 39 7 and and CC cord-003571-upogtny6 39 8 it -PRON- PRP cord-003571-upogtny6 39 9 will will MD cord-003571-upogtny6 39 10 be be VB cord-003571-upogtny6 39 11 important important JJ cord-003571-upogtny6 39 12 for for IN cord-003571-upogtny6 39 13 future future JJ cord-003571-upogtny6 39 14 work work NN cord-003571-upogtny6 39 15 to to TO cord-003571-upogtny6 39 16 reconcile reconcile VB cord-003571-upogtny6 39 17 the the DT cord-003571-upogtny6 39 18 well well RB cord-003571-upogtny6 39 19 - - HYPH cord-003571-upogtny6 39 20 accepted accept VBN cord-003571-upogtny6 39 21 idea idea NN cord-003571-upogtny6 39 22 that that IN cord-003571-upogtny6 39 23 a a DT cord-003571-upogtny6 39 24 1918-like 1918-like CD cord-003571-upogtny6 39 25 virus virus NN cord-003571-upogtny6 39 26 may may MD cord-003571-upogtny6 39 27 have have VB cord-003571-upogtny6 39 28 circulated circulate VBN cord-003571-upogtny6 39 29 in in IN cord-003571-upogtny6 39 30 Europe Europe NNP cord-003571-upogtny6 39 31 and and CC cord-003571-upogtny6 39 32 North North NNP cord-003571-upogtny6 39 33 America America NNP cord-003571-upogtny6 39 34 in in IN cord-003571-upogtny6 39 35 the the DT cord-003571-upogtny6 39 36 second second JJ cord-003571-upogtny6 39 37 half half NN cord-003571-upogtny6 39 38 of of IN cord-003571-upogtny6 39 39 the the DT cord-003571-upogtny6 39 40 19th 19th JJ cord-003571-upogtny6 39 41 century century NN cord-003571-upogtny6 39 42 , , , cord-003571-upogtny6 39 43 with with IN cord-003571-upogtny6 39 44 the the DT cord-003571-upogtny6 39 45 notion notion NN cord-003571-upogtny6 39 46 that that IN cord-003571-upogtny6 39 47 Madrid Madrid NNP cord-003571-upogtny6 39 48 would would MD cord-003571-upogtny6 39 49 have have VB cord-003571-upogtny6 39 50 escaped escape VBN cord-003571-upogtny6 39 51 this this DT cord-003571-upogtny6 39 52 virus virus NN cord-003571-upogtny6 39 53 . . . cord-003571-upogtny6 40 1 To to TO cord-003571-upogtny6 40 2 understand understand VB cord-003571-upogtny6 40 3 the the DT cord-003571-upogtny6 40 4 unique unique JJ cord-003571-upogtny6 40 5 epidemiology epidemiology NN cord-003571-upogtny6 40 6 of of IN cord-003571-upogtny6 40 7 the the DT cord-003571-upogtny6 40 8 1918 1918 CD cord-003571-upogtny6 40 9 virus virus NN cord-003571-upogtny6 40 10 , , , cord-003571-upogtny6 40 11 it -PRON- PRP cord-003571-upogtny6 40 12 can can MD cord-003571-upogtny6 40 13 be be VB cord-003571-upogtny6 40 14 useful useful JJ cord-003571-upogtny6 40 15 to to TO cord-003571-upogtny6 40 16 document document VB cord-003571-upogtny6 40 17 the the DT cord-003571-upogtny6 40 18 experience experience NN cord-003571-upogtny6 40 19 of of IN cord-003571-upogtny6 40 20 remote remote JJ cord-003571-upogtny6 40 21 populations population NNS cord-003571-upogtny6 40 22 , , , cord-003571-upogtny6 40 23 in in IN cord-003571-upogtny6 40 24 which which WDT cord-003571-upogtny6 40 25 prior prior JJ cord-003571-upogtny6 40 26 immunity immunity NN cord-003571-upogtny6 40 27 to to IN cord-003571-upogtny6 40 28 influenza influenza NN cord-003571-upogtny6 40 29 would would MD cord-003571-upogtny6 40 30 be be VB cord-003571-upogtny6 40 31 expected expect VBN cord-003571-upogtny6 40 32 to to TO cord-003571-upogtny6 40 33 be be VB cord-003571-upogtny6 40 34 low low JJ cord-003571-upogtny6 40 35 because because IN cord-003571-upogtny6 40 36 of of IN cord-003571-upogtny6 40 37 less less RBR cord-003571-upogtny6 40 38 frequent frequent JJ cord-003571-upogtny6 40 39 circulation circulation NN cord-003571-upogtny6 40 40 of of IN cord-003571-upogtny6 40 41 the the DT cord-003571-upogtny6 40 42 virus virus NN cord-003571-upogtny6 40 43 . . . cord-003571-upogtny6 41 1 Rice Rice NNP cord-003571-upogtny6 41 2 ( ( -LRB- cord-003571-upogtny6 41 3 8) 8) NNP cord-003571-upogtny6 41 4 built build VBD cord-003571-upogtny6 41 5 on on IN cord-003571-upogtny6 41 6 a a DT cord-003571-upogtny6 41 7 rich rich JJ cord-003571-upogtny6 41 8 literature literature NN cord-003571-upogtny6 41 9 in in IN cord-003571-upogtny6 41 10 this this DT cord-003571-upogtny6 41 11 area area NN cord-003571-upogtny6 41 12 to to TO cord-003571-upogtny6 41 13 document document VB cord-003571-upogtny6 41 14 mortality mortality NN cord-003571-upogtny6 41 15 patterns pattern NNS cord-003571-upogtny6 41 16 in in IN cord-003571-upogtny6 41 17 New New NNP cord-003571-upogtny6 41 18 Zealand Zealand NNP cord-003571-upogtny6 41 19 between between IN cord-003571-upogtny6 41 20 1890 1890 CD cord-003571-upogtny6 41 21 and and CC cord-003571-upogtny6 41 22 1918 1918 CD cord-003571-upogtny6 41 23 . . . cord-003571-upogtny6 42 1 He -PRON- PRP cord-003571-upogtny6 42 2 found find VBD cord-003571-upogtny6 42 3 that that IN cord-003571-upogtny6 42 4 the the DT cord-003571-upogtny6 42 5 1890s 1890s CD cord-003571-upogtny6 42 6 were be VBD cord-003571-upogtny6 42 7 a a DT cord-003571-upogtny6 42 8 decade decade NN cord-003571-upogtny6 42 9 associated associate VBN cord-003571-upogtny6 42 10 with with IN cord-003571-upogtny6 42 11 high high JJ cord-003571-upogtny6 42 12 rate rate NN cord-003571-upogtny6 42 13 of of IN cord-003571-upogtny6 42 14 influenza influenza NN cord-003571-upogtny6 42 15 mortality mortality NN cord-003571-upogtny6 42 16 in in IN cord-003571-upogtny6 42 17 New New NNP cord-003571-upogtny6 42 18 Zealand Zealand NNP cord-003571-upogtny6 42 19 , , , cord-003571-upogtny6 42 20 despite despite IN cord-003571-upogtny6 42 21 the the DT cord-003571-upogtny6 42 22 low low JJ cord-003571-upogtny6 42 23 global global JJ cord-003571-upogtny6 42 24 connectivity connectivity NN cord-003571-upogtny6 42 25 of of IN cord-003571-upogtny6 42 26 this this DT cord-003571-upogtny6 42 27 island island NN cord-003571-upogtny6 42 28 in in IN cord-003571-upogtny6 42 29 the the DT cord-003571-upogtny6 42 30 era era NN cord-003571-upogtny6 42 31 before before IN cord-003571-upogtny6 42 32 air air NN cord-003571-upogtny6 42 33 travel travel NN cord-003571-upogtny6 42 34 . . . cord-003571-upogtny6 43 1 He -PRON- PRP cord-003571-upogtny6 43 2 also also RB cord-003571-upogtny6 43 3 noted note VBD cord-003571-upogtny6 43 4 that that IN cord-003571-upogtny6 43 5 influenza influenza NN cord-003571-upogtny6 43 6 mortality mortality NN cord-003571-upogtny6 43 7 in in IN cord-003571-upogtny6 43 8 1918 1918 CD cord-003571-upogtny6 43 9 was be VBD cord-003571-upogtny6 43 10 highest high JJS cord-003571-upogtny6 43 11 among among IN cord-003571-upogtny6 43 12 young young JJ cord-003571-upogtny6 43 13 adults adult NNS cord-003571-upogtny6 43 14 , , , cord-003571-upogtny6 43 15 with with IN cord-003571-upogtny6 43 16 a a DT cord-003571-upogtny6 43 17 more more RBR cord-003571-upogtny6 43 18 pronounced pronounced JJ cord-003571-upogtny6 43 19 intensity intensity NN cord-003571-upogtny6 43 20 in in IN cord-003571-upogtny6 43 21 males male NNS cord-003571-upogtny6 43 22 than than IN cord-003571-upogtny6 43 23 in in IN cord-003571-upogtny6 43 24 females female NNS cord-003571-upogtny6 43 25 . . . cord-003571-upogtny6 44 1 These these DT cord-003571-upogtny6 44 2 patterns pattern NNS cord-003571-upogtny6 44 3 are be VBP cord-003571-upogtny6 44 4 broadly broadly RB cord-003571-upogtny6 44 5 consistent consistent JJ cord-003571-upogtny6 44 6 with with IN cord-003571-upogtny6 44 7 the the DT cord-003571-upogtny6 44 8 those those DT cord-003571-upogtny6 44 9 among among IN cord-003571-upogtny6 44 10 young young JJ cord-003571-upogtny6 44 11 adults adult NNS cord-003571-upogtny6 44 12 in in IN cord-003571-upogtny6 44 13 Europe Europe NNP cord-003571-upogtny6 44 14 and and CC cord-003571-upogtny6 44 15 the the DT cord-003571-upogtny6 44 16 Americas Americas NNPS cord-003571-upogtny6 44 17 , , , cord-003571-upogtny6 44 18 pointing point VBG cord-003571-upogtny6 44 19 to to IN cord-003571-upogtny6 44 20 the the DT cord-003571-upogtny6 44 21 near near JJ cord-003571-upogtny6 44 22 universality universality NN cord-003571-upogtny6 44 23 of of IN cord-003571-upogtny6 44 24 increased increase VBN cord-003571-upogtny6 44 25 influenza influenza NN cord-003571-upogtny6 44 26 mortality mortality NN cord-003571-upogtny6 44 27 risk risk NN cord-003571-upogtny6 44 28 in in IN cord-003571-upogtny6 44 29 this this DT cord-003571-upogtny6 44 30 age age NN cord-003571-upogtny6 44 31 group group NN cord-003571-upogtny6 44 32 in in IN cord-003571-upogtny6 44 33 1918 1918 CD cord-003571-upogtny6 44 34 . . . cord-003571-upogtny6 45 1 Chuah Chuah NNP cord-003571-upogtny6 45 2 et et FW cord-003571-upogtny6 45 3 al al NNP cord-003571-upogtny6 45 4 . . . cord-003571-upogtny6 46 1 ( ( -LRB- cord-003571-upogtny6 46 2 9 9 LS cord-003571-upogtny6 46 3 ) ) -RRB- cord-003571-upogtny6 46 4 used use VBN cord-003571-upogtny6 46 5 seroepidemiology seroepidemiology NN cord-003571-upogtny6 46 6 and and CC cord-003571-upogtny6 46 7 structural structural JJ cord-003571-upogtny6 46 8 equation equation NN cord-003571-upogtny6 46 9 modeling model VBG cord-003571-upogtny6 46 10 to to TO cord-003571-upogtny6 46 11 answer answer VB cord-003571-upogtny6 46 12 the the DT cord-003571-upogtny6 46 13 inverse inverse JJ cord-003571-upogtny6 46 14 question question NN cord-003571-upogtny6 46 15 : : : cord-003571-upogtny6 46 16 How how WRB cord-003571-upogtny6 46 17 did do VBD cord-003571-upogtny6 46 18 early early JJ cord-003571-upogtny6 46 19 - - HYPH cord-003571-upogtny6 46 20 life life NN cord-003571-upogtny6 46 21 exposure exposure NN cord-003571-upogtny6 46 22 to to IN cord-003571-upogtny6 46 23 the the DT cord-003571-upogtny6 46 24 1918 1918 CD cord-003571-upogtny6 46 25 pandemic pandemic NNP cord-003571-upogtny6 46 26 virus virus NN cord-003571-upogtny6 46 27 impact impact NN cord-003571-upogtny6 46 28 how how WRB cord-003571-upogtny6 46 29 people people NNS cord-003571-upogtny6 46 30 responded respond VBD cord-003571-upogtny6 46 31 to to IN cord-003571-upogtny6 46 32 the the DT cord-003571-upogtny6 46 33 2009 2009 CD cord-003571-upogtny6 46 34 pandemic pandemic NN cord-003571-upogtny6 46 35 , , , cord-003571-upogtny6 46 36 which which WDT cord-003571-upogtny6 46 37 was be VBD cord-003571-upogtny6 46 38 caused cause VBN cord-003571-upogtny6 46 39 by by IN cord-003571-upogtny6 46 40 an an DT cord-003571-upogtny6 46 41 antigenically antigenically RB cord-003571-upogtny6 46 42 similar similar JJ cord-003571-upogtny6 46 43 virus virus NN cord-003571-upogtny6 46 44 ? ? . cord-003571-upogtny6 47 1 They -PRON- PRP cord-003571-upogtny6 47 2 found find VBD cord-003571-upogtny6 47 3 evidence evidence NN cord-003571-upogtny6 47 4 for for IN cord-003571-upogtny6 47 5 immunologic immunologic JJ cord-003571-upogtny6 47 6 priming priming NN cord-003571-upogtny6 47 7 from from IN cord-003571-upogtny6 47 8 the the DT cord-003571-upogtny6 47 9 1918 1918 CD cord-003571-upogtny6 47 10 virus virus NN cord-003571-upogtny6 47 11 in in IN cord-003571-upogtny6 47 12 the the DT cord-003571-upogtny6 47 13 oldest old JJS cord-003571-upogtny6 47 14 people people NNS cord-003571-upogtny6 47 15 they -PRON- PRP cord-003571-upogtny6 47 16 studied study VBD cord-003571-upogtny6 47 17 ( ( -LRB- cord-003571-upogtny6 47 18 individuals individual NNS cord-003571-upogtny6 47 19 80 80 CD cord-003571-upogtny6 47 20 years year NNS cord-003571-upogtny6 47 21 of of IN cord-003571-upogtny6 47 22 age age NN cord-003571-upogtny6 47 23 or or CC cord-003571-upogtny6 47 24 older old JJR cord-003571-upogtny6 47 25 ) ) -RRB- cord-003571-upogtny6 47 26 that that WDT cord-003571-upogtny6 47 27 impacted impact VBD cord-003571-upogtny6 47 28 both both DT cord-003571-upogtny6 47 29 baseline baseline JJ cord-003571-upogtny6 47 30 titers titer NNS cord-003571-upogtny6 47 31 and and CC cord-003571-upogtny6 47 32 vaccine vaccine NN cord-003571-upogtny6 47 33 response response NN cord-003571-upogtny6 47 34 in in IN cord-003571-upogtny6 47 35 2009 2009 CD cord-003571-upogtny6 47 36 . . . cord-003571-upogtny6 48 1 This this DT cord-003571-upogtny6 48 2 work work NN cord-003571-upogtny6 48 3 adds add VBZ cord-003571-upogtny6 48 4 to to IN cord-003571-upogtny6 48 5 a a DT cord-003571-upogtny6 48 6 growing grow VBG cord-003571-upogtny6 48 7 body body NN cord-003571-upogtny6 48 8 of of IN cord-003571-upogtny6 48 9 evidence evidence NN cord-003571-upogtny6 48 10 that that IN cord-003571-upogtny6 48 11 early early JJ cord-003571-upogtny6 48 12 - - HYPH cord-003571-upogtny6 48 13 life life NN cord-003571-upogtny6 48 14 exposures exposure NNS cord-003571-upogtny6 48 15 can can MD cord-003571-upogtny6 48 16 have have VB cord-003571-upogtny6 48 17 profound profound JJ cord-003571-upogtny6 48 18 effects effect NNS cord-003571-upogtny6 48 19 on on IN cord-003571-upogtny6 48 20 immune immune JJ cord-003571-upogtny6 48 21 response response NN cord-003571-upogtny6 48 22 and and CC cord-003571-upogtny6 48 23 mortality mortality NN cord-003571-upogtny6 48 24 patterns pattern NNS cord-003571-upogtny6 48 25 decades decade NNS cord-003571-upogtny6 48 26 after after IN cord-003571-upogtny6 48 27 they -PRON- PRP cord-003571-upogtny6 48 28 occur occur VBP cord-003571-upogtny6 48 29 ( ( -LRB- cord-003571-upogtny6 48 30 18 18 CD cord-003571-upogtny6 48 31 ) ) -RRB- cord-003571-upogtny6 48 32 . . . cord-003571-upogtny6 49 1 Information information NN cord-003571-upogtny6 49 2 about about IN cord-003571-upogtny6 49 3 global global JJ cord-003571-upogtny6 49 4 connectivity connectivity NN cord-003571-upogtny6 49 5 in in IN cord-003571-upogtny6 49 6 the the DT cord-003571-upogtny6 49 7 19th 19th JJ cord-003571-upogtny6 49 8 century century NN cord-003571-upogtny6 49 9 is be VBZ cord-003571-upogtny6 49 10 tenuous tenuous JJ cord-003571-upogtny6 49 11 , , , cord-003571-upogtny6 49 12 and and CC cord-003571-upogtny6 49 13 influenza influenza NN cord-003571-upogtny6 49 14 records record NNS cord-003571-upogtny6 49 15 before before IN cord-003571-upogtny6 49 16 1890 1890 CD cord-003571-upogtny6 49 17 are be VBP cord-003571-upogtny6 49 18 scarce scarce JJ cord-003571-upogtny6 49 19 . . . cord-003571-upogtny6 50 1 Epidemiologic epidemiologic JJ cord-003571-upogtny6 50 2 reconstructions reconstruction NNS cord-003571-upogtny6 50 3 of of IN cord-003571-upogtny6 50 4 " " `` cord-003571-upogtny6 50 5 modern modern JJ cord-003571-upogtny6 50 6 " " '' cord-003571-upogtny6 50 7 pandemics pandemic NNS cord-003571-upogtny6 50 8 of of IN cord-003571-upogtny6 50 9 the the DT cord-003571-upogtny6 50 10 type type NN cord-003571-upogtny6 50 11 presented present VBN cord-003571-upogtny6 50 12 here here RB cord-003571-upogtny6 50 13 ( ( -LRB- cord-003571-upogtny6 50 14 6 6 CD cord-003571-upogtny6 50 15 - - SYM cord-003571-upogtny6 50 16 9 9 CD cord-003571-upogtny6 50 17 ) ) -RRB- cord-003571-upogtny6 50 18 provide provide VB cord-003571-upogtny6 50 19 indirect indirect JJ cord-003571-upogtny6 50 20 information information NN cord-003571-upogtny6 50 21 on on IN cord-003571-upogtny6 50 22 the the DT cord-003571-upogtny6 50 23 exposures exposure NNS cord-003571-upogtny6 50 24 of of IN cord-003571-upogtny6 50 25 populations population NNS cord-003571-upogtny6 50 26 that that WDT cord-003571-upogtny6 50 27 are be VBP cord-003571-upogtny6 50 28 now now RB cord-003571-upogtny6 50 29 long long RB cord-003571-upogtny6 50 30 gone go VBN cord-003571-upogtny6 50 31 , , , cord-003571-upogtny6 50 32 generating generate VBG cord-003571-upogtny6 50 33 valuable valuable JJ cord-003571-upogtny6 50 34 hypotheses hypothesis NNS cord-003571-upogtny6 50 35 about about IN cord-003571-upogtny6 50 36 influenza influenza NN cord-003571-upogtny6 50 37 circulation circulation NN cord-003571-upogtny6 50 38 patterns pattern NNS cord-003571-upogtny6 50 39 and and CC cord-003571-upogtny6 50 40 disease disease NN cord-003571-upogtny6 50 41 dynamics dynamic NNS cord-003571-upogtny6 50 42 well well RB cord-003571-upogtny6 50 43 into into IN cord-003571-upogtny6 50 44 the the DT cord-003571-upogtny6 50 45 19th 19th JJ cord-003571-upogtny6 50 46 century century NN cord-003571-upogtny6 50 47 . . . cord-003571-upogtny6 51 1 Such such JJ cord-003571-upogtny6 51 2 reconstructions reconstruction NNS cord-003571-upogtny6 51 3 offer offer VBP cord-003571-upogtny6 51 4 precious precious JJ cord-003571-upogtny6 51 5 insights insight NNS cord-003571-upogtny6 51 6 into into IN cord-003571-upogtny6 51 7 what what WDT cord-003571-upogtny6 51 8 influenza influenza NN cord-003571-upogtny6 51 9 may may MD cord-003571-upogtny6 51 10 have have VB cord-003571-upogtny6 51 11 looked look VBN cord-003571-upogtny6 51 12 like like IN cord-003571-upogtny6 51 13 200 200 CD cord-003571-upogtny6 51 14 years year NNS cord-003571-upogtny6 51 15 ago ago RB cord-003571-upogtny6 51 16 in in IN cord-003571-upogtny6 51 17 a a DT cord-003571-upogtny6 51 18 very very RB cord-003571-upogtny6 51 19 different different JJ cord-003571-upogtny6 51 20 world world NN cord-003571-upogtny6 51 21 and and CC cord-003571-upogtny6 51 22 how how WRB cord-003571-upogtny6 51 23 long long JJ cord-003571-upogtny6 51 24 - - HYPH cord-003571-upogtny6 51 25 term term NN cord-003571-upogtny6 51 26 changes change NNS cord-003571-upogtny6 51 27 in in IN cord-003571-upogtny6 51 28 human human JJ cord-003571-upogtny6 51 29 demography demography NN cord-003571-upogtny6 51 30 and and CC cord-003571-upogtny6 51 31 mobility mobility NN cord-003571-upogtny6 51 32 may may MD cord-003571-upogtny6 51 33 affect affect VB cord-003571-upogtny6 51 34 disease disease NN cord-003571-upogtny6 51 35 dynamics dynamic NNS cord-003571-upogtny6 51 36 ( ( -LRB- cord-003571-upogtny6 51 37 22 22 CD cord-003571-upogtny6 51 38 ) ) -RRB- cord-003571-upogtny6 51 39 . . . cord-003571-upogtny6 52 1 Active active JJ cord-003571-upogtny6 52 2 research research NN cord-003571-upogtny6 52 3 topics topic NNS cord-003571-upogtny6 52 4 in in IN cord-003571-upogtny6 52 5 the the DT cord-003571-upogtny6 52 6 field field NN cord-003571-upogtny6 52 7 of of IN cord-003571-upogtny6 52 8 archeo archeo NN cord-003571-upogtny6 52 9 - - HYPH cord-003571-upogtny6 52 10 epidemiology epidemiology NN cord-003571-upogtny6 52 11 include include VBP cord-003571-upogtny6 52 12 the the DT cord-003571-upogtny6 52 13 search search NN cord-003571-upogtny6 52 14 for for IN cord-003571-upogtny6 52 15 predictors predictor NNS cord-003571-upogtny6 52 16 of of IN cord-003571-upogtny6 52 17 influenza influenza NN cord-003571-upogtny6 52 18 mortality mortality NN cord-003571-upogtny6 52 19 , , , cord-003571-upogtny6 52 20 such such JJ cord-003571-upogtny6 52 21 as as IN cord-003571-upogtny6 52 22 socioeconomic socioeconomic JJ cord-003571-upogtny6 52 23 indicators indicator NNS cord-003571-upogtny6 52 24 or or CC cord-003571-upogtny6 52 25 geography geography NN cord-003571-upogtny6 52 26 , , , cord-003571-upogtny6 52 27 and and CC cord-003571-upogtny6 52 28 the the DT cord-003571-upogtny6 52 29 drivers driver NNS cord-003571-upogtny6 52 30 of of IN cord-003571-upogtny6 52 31 influenza influenza NN cord-003571-upogtny6 52 32 spatial spatial JJ cord-003571-upogtny6 52 33 diffusion diffusion NN cord-003571-upogtny6 52 34 . . . cord-003571-upogtny6 53 1 In in IN cord-003571-upogtny6 53 2 2 2 CD cord-003571-upogtny6 53 3 articles article NNS cord-003571-upogtny6 53 4 in in IN cord-003571-upogtny6 53 5 the the DT cord-003571-upogtny6 53 6 present present JJ cord-003571-upogtny6 53 7 issue issue NN cord-003571-upogtny6 53 8 , , , cord-003571-upogtny6 53 9 the the DT cord-003571-upogtny6 53 10 authors author NNS cord-003571-upogtny6 53 11 concentrated concentrate VBD cord-003571-upogtny6 53 12 on on IN cord-003571-upogtny6 53 13 the the DT cord-003571-upogtny6 53 14 spatial spatial JJ cord-003571-upogtny6 53 15 diffusion diffusion NN cord-003571-upogtny6 53 16 of of IN cord-003571-upogtny6 53 17 influenza influenza NN cord-003571-upogtny6 53 18 , , , cord-003571-upogtny6 53 19 focusing focus VBG cord-003571-upogtny6 53 20 on on IN cord-003571-upogtny6 53 21 British british JJ cord-003571-upogtny6 53 22 India India NNP cord-003571-upogtny6 53 23 and and CC cord-003571-upogtny6 53 24 Portugal Portugal NNP cord-003571-upogtny6 53 25 , , , cord-003571-upogtny6 53 26 2 2 CD cord-003571-upogtny6 53 27 countries country NNS cord-003571-upogtny6 53 28 that that WDT cord-003571-upogtny6 53 29 have have VBP cord-003571-upogtny6 53 30 been be VBN cord-003571-upogtny6 53 31 poorly poorly RB cord-003571-upogtny6 53 32 studied study VBN cord-003571-upogtny6 53 33 in in IN cord-003571-upogtny6 53 34 the the DT cord-003571-upogtny6 53 35 context context NN cord-003571-upogtny6 53 36 of of IN cord-003571-upogtny6 53 37 the the DT cord-003571-upogtny6 53 38 1918 1918 CD cord-003571-upogtny6 53 39 pandemic pandemic NN cord-003571-upogtny6 53 40 ( ( -LRB- cord-003571-upogtny6 53 41 10 10 CD cord-003571-upogtny6 53 42 , , , cord-003571-upogtny6 53 43 11 11 CD cord-003571-upogtny6 53 44 ) ) -RRB- cord-003571-upogtny6 53 45 . . . cord-003571-upogtny6 54 1 Both both DT cord-003571-upogtny6 54 2 studies study NNS cord-003571-upogtny6 54 3 revealed reveal VBD cord-003571-upogtny6 54 4 a a DT cord-003571-upogtny6 54 5 highly highly RB cord-003571-upogtny6 54 6 heterogeneous heterogeneous JJ cord-003571-upogtny6 54 7 spread spread NN cord-003571-upogtny6 54 8 of of IN cord-003571-upogtny6 54 9 the the DT cord-003571-upogtny6 54 10 pandemic pandemic NN cord-003571-upogtny6 54 11 and and CC cord-003571-upogtny6 54 12 geographic geographic JJ cord-003571-upogtny6 54 13 variation variation NN cord-003571-upogtny6 54 14 in in IN cord-003571-upogtny6 54 15 pandemic pandemic NN cord-003571-upogtny6 54 16 mortality mortality NN cord-003571-upogtny6 54 17 impact impact NN cord-003571-upogtny6 54 18 , , , cord-003571-upogtny6 54 19 albeit albeit IN cord-003571-upogtny6 54 20 at at IN cord-003571-upogtny6 54 21 different different JJ cord-003571-upogtny6 54 22 spatial spatial JJ cord-003571-upogtny6 54 23 scales scale NNS cord-003571-upogtny6 54 24 . . . cord-003571-upogtny6 55 1 Although although IN cord-003571-upogtny6 55 2 Portugal Portugal NNP cord-003571-upogtny6 55 3 as as IN cord-003571-upogtny6 55 4 a a DT cord-003571-upogtny6 55 5 whole whole NN cord-003571-upogtny6 55 6 was be VBD cord-003571-upogtny6 55 7 severely severely RB cord-003571-upogtny6 55 8 hit hit VBN cord-003571-upogtny6 55 9 by by IN cord-003571-upogtny6 55 10 the the DT cord-003571-upogtny6 55 11 pandemic pandemic NN cord-003571-upogtny6 55 12 compared compare VBN cord-003571-upogtny6 55 13 with with IN cord-003571-upogtny6 55 14 other other JJ cord-003571-upogtny6 55 15 European european JJ cord-003571-upogtny6 55 16 countries country NNS cord-003571-upogtny6 55 17 , , , cord-003571-upogtny6 55 18 some some DT cord-003571-upogtny6 55 19 provinces province NNS cord-003571-upogtny6 55 20 nearly nearly RB cord-003571-upogtny6 55 21 fully fully RB cord-003571-upogtny6 55 22 escaped escape VBD cord-003571-upogtny6 55 23 ( ( -LRB- cord-003571-upogtny6 55 24 10 10 CD cord-003571-upogtny6 55 25 ) ) -RRB- cord-003571-upogtny6 55 26 . . . cord-003571-upogtny6 56 1 Analysis analysis NN cord-003571-upogtny6 56 2 of of IN cord-003571-upogtny6 56 3 district district NN cord-003571-upogtny6 56 4 - - HYPH cord-003571-upogtny6 56 5 level level NN cord-003571-upogtny6 56 6 mortality mortality NN cord-003571-upogtny6 56 7 records record NNS cord-003571-upogtny6 56 8 in in IN cord-003571-upogtny6 56 9 India India NNP cord-003571-upogtny6 56 10 revealed reveal VBD cord-003571-upogtny6 56 11 a a DT cord-003571-upogtny6 56 12 northeastward northeastward JJ cord-003571-upogtny6 56 13 wave wave NN cord-003571-upogtny6 56 14 of of IN cord-003571-upogtny6 56 15 infection infection NN cord-003571-upogtny6 56 16 from from IN cord-003571-upogtny6 56 17 September September NNP cord-003571-upogtny6 56 18 to to IN cord-003571-upogtny6 56 19 November November NNP cord-003571-upogtny6 56 20 1918 1918 CD cord-003571-upogtny6 56 21 that that WDT cord-003571-upogtny6 56 22 was be VBD cord-003571-upogtny6 56 23 associated associate VBN cord-003571-upogtny6 56 24 with with IN cord-003571-upogtny6 56 25 climate climate NN cord-003571-upogtny6 56 26 and and CC cord-003571-upogtny6 56 27 population population NN cord-003571-upogtny6 56 28 density density NN cord-003571-upogtny6 56 29 ( ( -LRB- cord-003571-upogtny6 56 30 11 11 CD cord-003571-upogtny6 56 31 ) ) -RRB- cord-003571-upogtny6 56 32 . . . cord-003571-upogtny6 57 1 Diffusion diffusion NN cord-003571-upogtny6 57 2 was be VBD cord-003571-upogtny6 57 3 driven drive VBN cord-003571-upogtny6 57 4 by by IN cord-003571-upogtny6 57 5 long long JJ cord-003571-upogtny6 57 6 - - HYPH cord-003571-upogtny6 57 7 distance distance NN cord-003571-upogtny6 57 8 jumps jump VBZ cord-003571-upogtny6 57 9 via via IN cord-003571-upogtny6 57 10 the the DT cord-003571-upogtny6 57 11 railroad railroad NN cord-003571-upogtny6 57 12 network network NN cord-003571-upogtny6 57 13 , , , cord-003571-upogtny6 57 14 superimposed superimpose VBN cord-003571-upogtny6 57 15 on on IN cord-003571-upogtny6 57 16 local local JJ cord-003571-upogtny6 57 17 diffusion diffusion NN cord-003571-upogtny6 57 18 between between IN cord-003571-upogtny6 57 19 neighboring neighboring NN cord-003571-upogtny6 57 20 provinces province NNS cord-003571-upogtny6 57 21 . . . cord-003571-upogtny6 58 1 Further further RB cord-003571-upogtny6 58 2 , , , cord-003571-upogtny6 58 3 the the DT cord-003571-upogtny6 58 4 authors author NNS cord-003571-upogtny6 58 5 found find VBD cord-003571-upogtny6 58 6 moderate moderate JJ cord-003571-upogtny6 58 7 heterogeneity heterogeneity NN cord-003571-upogtny6 58 8 in in IN cord-003571-upogtny6 58 9 the the DT cord-003571-upogtny6 58 10 mortality mortality NN cord-003571-upogtny6 58 11 experiences experience NNS cord-003571-upogtny6 58 12 of of IN cord-003571-upogtny6 58 13 different different JJ cord-003571-upogtny6 58 14 Indian indian JJ cord-003571-upogtny6 58 15 provinces province NNS cord-003571-upogtny6 58 16 . . . cord-003571-upogtny6 59 1 Spreeuwenberg Spreeuwenberg NNP cord-003571-upogtny6 59 2 et et NNP cord-003571-upogtny6 59 3 al al NNP cord-003571-upogtny6 59 4 . . . cord-003571-upogtny6 60 1 ( ( -LRB- cord-003571-upogtny6 60 2 12 12 CD cord-003571-upogtny6 60 3 ) ) -RRB- cord-003571-upogtny6 60 4 also also RB cord-003571-upogtny6 60 5 made make VBD cord-003571-upogtny6 60 6 use use NN cord-003571-upogtny6 60 7 of of IN cord-003571-upogtny6 60 8 recently recently RB cord-003571-upogtny6 60 9 unearthed unearth VBN cord-003571-upogtny6 60 10 data datum NNS cord-003571-upogtny6 60 11 from from IN cord-003571-upogtny6 60 12 India India NNP cord-003571-upogtny6 60 13 to to TO cord-003571-upogtny6 60 14 revisit revisit VB cord-003571-upogtny6 60 15 the the DT cord-003571-upogtny6 60 16 global global JJ cord-003571-upogtny6 60 17 mortality mortality NN cord-003571-upogtny6 60 18 impact impact NN cord-003571-upogtny6 60 19 of of IN cord-003571-upogtny6 60 20 the the DT cord-003571-upogtny6 60 21 1918 1918 CD cord-003571-upogtny6 60 22 pandemic pandemic NN cord-003571-upogtny6 60 23 . . . cord-003571-upogtny6 61 1 India India NNP cord-003571-upogtny6 61 2 is be VBZ cord-003571-upogtny6 61 3 a a DT cord-003571-upogtny6 61 4 particularly particularly RB cord-003571-upogtny6 61 5 important important JJ cord-003571-upogtny6 61 6 country country NN cord-003571-upogtny6 61 7 for for IN cord-003571-upogtny6 61 8 global global JJ cord-003571-upogtny6 61 9 burden burden NN cord-003571-upogtny6 61 10 estimation estimation NN cord-003571-upogtny6 61 11 because because IN cord-003571-upogtny6 61 12 it -PRON- PRP cord-003571-upogtny6 61 13 was be VBD cord-003571-upogtny6 61 14 the the DT cord-003571-upogtny6 61 15 one one NN cord-003571-upogtny6 61 16 most most RBS cord-003571-upogtny6 61 17 severely severely RB cord-003571-upogtny6 61 18 hit hit VBN cord-003571-upogtny6 61 19 by by IN cord-003571-upogtny6 61 20 the the DT cord-003571-upogtny6 61 21 1918 1918 CD cord-003571-upogtny6 61 22 pandemic pandemic NN cord-003571-upogtny6 61 23 , , , cord-003571-upogtny6 61 24 with with IN cord-003571-upogtny6 61 25 annual annual JJ cord-003571-upogtny6 61 26 pandemic pandemic NN cord-003571-upogtny6 61 27 excess excess JJ cord-003571-upogtny6 61 28 mortality mortality NN cord-003571-upogtny6 61 29 rates rate NNS cord-003571-upogtny6 61 30 that that WDT cord-003571-upogtny6 61 31 were be VBD cord-003571-upogtny6 61 32 40-fold 40-fold CD cord-003571-upogtny6 61 33 higher high JJR cord-003571-upogtny6 61 34 than than IN cord-003571-upogtny6 61 35 those those DT cord-003571-upogtny6 61 36 in in IN cord-003571-upogtny6 61 37 Denmark Denmark NNP cord-003571-upogtny6 61 38 for for IN cord-003571-upogtny6 61 39 instance instance NN cord-003571-upogtny6 61 40 ( ( -LRB- cord-003571-upogtny6 61 41 23 23 CD cord-003571-upogtny6 61 42 ) ) -RRB- cord-003571-upogtny6 61 43 . . . cord-003571-upogtny6 62 1 In in IN cord-003571-upogtny6 62 2 the the DT cord-003571-upogtny6 62 3 new new JJ cord-003571-upogtny6 62 4 study study NN cord-003571-upogtny6 62 5 , , , cord-003571-upogtny6 62 6 the the DT cord-003571-upogtny6 62 7 authors author NNS cord-003571-upogtny6 62 8 placed place VBD cord-003571-upogtny6 62 9 the the DT cord-003571-upogtny6 62 10 burden burden NN cord-003571-upogtny6 62 11 of of IN cord-003571-upogtny6 62 12 the the DT cord-003571-upogtny6 62 13 pandemic pandemic NN cord-003571-upogtny6 62 14 at at IN cord-003571-upogtny6 62 15 a a DT cord-003571-upogtny6 62 16 much much RB cord-003571-upogtny6 62 17 lower low JJR cord-003571-upogtny6 62 18 number number NN cord-003571-upogtny6 62 19 than than IN cord-003571-upogtny6 62 20 did do VBD cord-003571-upogtny6 62 21 previous previous JJ cord-003571-upogtny6 62 22 work work NN cord-003571-upogtny6 62 23 ( ( -LRB- cord-003571-upogtny6 62 24 12 12 CD cord-003571-upogtny6 62 25 ) ) -RRB- cord-003571-upogtny6 62 26 , , , cord-003571-upogtny6 62 27 in in IN cord-003571-upogtny6 62 28 part part NN cord-003571-upogtny6 62 29 by by IN cord-003571-upogtny6 62 30 using use VBG cord-003571-upogtny6 62 31 more more RBR cord-003571-upogtny6 62 32 detailed detailed JJ cord-003571-upogtny6 62 33 data datum NNS cord-003571-upogtny6 62 34 to to TO cord-003571-upogtny6 62 35 better better RB cord-003571-upogtny6 62 36 adjust adjust VB cord-003571-upogtny6 62 37 for for IN cord-003571-upogtny6 62 38 high high JJ cord-003571-upogtny6 62 39 background background NN cord-003571-upogtny6 62 40 mortality mortality NN cord-003571-upogtny6 62 41 unrelated unrelated JJ cord-003571-upogtny6 62 42 to to IN cord-003571-upogtny6 62 43 flu flu NN cord-003571-upogtny6 62 44 . . . cord-003571-upogtny6 63 1 The the DT cord-003571-upogtny6 63 2 results result NNS cord-003571-upogtny6 63 3 of of IN cord-003571-upogtny6 63 4 the the DT cord-003571-upogtny6 63 5 Portuguese portuguese JJ cord-003571-upogtny6 63 6 study study NN cord-003571-upogtny6 63 7 by by IN cord-003571-upogtny6 63 8 Nunes Nunes NNP cord-003571-upogtny6 63 9 et et NNP cord-003571-upogtny6 63 10 al al NNP cord-003571-upogtny6 63 11 . . . cord-003571-upogtny6 64 1 ( ( -LRB- cord-003571-upogtny6 64 2 10 10 CD cord-003571-upogtny6 64 3 ) ) -RRB- cord-003571-upogtny6 64 4 echoed echo VBD cord-003571-upogtny6 64 5 these these DT cord-003571-upogtny6 64 6 conclusions conclusion NNS cord-003571-upogtny6 64 7 - - : cord-003571-upogtny6 64 8 that that IN cord-003571-upogtny6 64 9 careful careful JJ cord-003571-upogtny6 64 10 analyses analysis NNS cord-003571-upogtny6 64 11 of of IN cord-003571-upogtny6 64 12 more more RBR cord-003571-upogtny6 64 13 detailed detailed JJ cord-003571-upogtny6 64 14 data datum NNS cord-003571-upogtny6 64 15 tend tend VBP cord-003571-upogtny6 64 16 to to TO cord-003571-upogtny6 64 17 decrease decrease VB cord-003571-upogtny6 64 18 estimates estimate NNS cord-003571-upogtny6 64 19 of of IN cord-003571-upogtny6 64 20 pandemic pandemic JJ cord-003571-upogtny6 64 21 burden burden NN cord-003571-upogtny6 64 22 . . . cord-003571-upogtny6 65 1 The the DT cord-003571-upogtny6 65 2 risk risk NN cord-003571-upogtny6 65 3 factors factor NNS cord-003571-upogtny6 65 4 responsible responsible JJ cord-003571-upogtny6 65 5 for for IN cord-003571-upogtny6 65 6 increased increase VBN cord-003571-upogtny6 65 7 mortality mortality NN cord-003571-upogtny6 65 8 and and CC cord-003571-upogtny6 65 9 morbidity morbidity NN cord-003571-upogtny6 65 10 from from IN cord-003571-upogtny6 65 11 influenza influenza NN cord-003571-upogtny6 65 12 remain remain VBP cord-003571-upogtny6 65 13 elusive elusive JJ cord-003571-upogtny6 65 14 , , , cord-003571-upogtny6 65 15 whether whether IN cord-003571-upogtny6 65 16 at at IN cord-003571-upogtny6 65 17 the the DT cord-003571-upogtny6 65 18 population population NN cord-003571-upogtny6 65 19 level level NN cord-003571-upogtny6 65 20 ( ( -LRB- cord-003571-upogtny6 65 21 e.g. e.g. RB cord-003571-upogtny6 65 22 , , , cord-003571-upogtny6 65 23 effect effect NN cord-003571-upogtny6 65 24 of of IN cord-003571-upogtny6 65 25 population population NN cord-003571-upogtny6 65 26 density density NN cord-003571-upogtny6 65 27 or or CC cord-003571-upogtny6 65 28 weather weather NN cord-003571-upogtny6 65 29 on on IN cord-003571-upogtny6 65 30 transmission transmission NN cord-003571-upogtny6 65 31 ) ) -RRB- cord-003571-upogtny6 65 32 or or CC cord-003571-upogtny6 65 33 the the DT cord-003571-upogtny6 65 34 individual individual JJ cord-003571-upogtny6 65 35 level level NN cord-003571-upogtny6 65 36 ( ( -LRB- cord-003571-upogtny6 65 37 socioeconomic socioeconomic JJ cord-003571-upogtny6 65 38 status status NN cord-003571-upogtny6 65 39 , , , cord-003571-upogtny6 65 40 comorbid comorbid NN cord-003571-upogtny6 65 41 conditions condition NNS cord-003571-upogtny6 65 42 , , , cord-003571-upogtny6 65 43 etc etc FW cord-003571-upogtny6 65 44 . . . cord-003571-upogtny6 65 45 ) ) -RRB- cord-003571-upogtny6 65 46 . . . cord-003571-upogtny6 66 1 This this DT cord-003571-upogtny6 66 2 is be VBZ cord-003571-upogtny6 66 3 still still RB cord-003571-upogtny6 66 4 an an DT cord-003571-upogtny6 66 5 active active JJ cord-003571-upogtny6 66 6 area area NN cord-003571-upogtny6 66 7 of of IN cord-003571-upogtny6 66 8 contemporary contemporary JJ cord-003571-upogtny6 66 9 influenza influenza NN cord-003571-upogtny6 66 10 research research NN cord-003571-upogtny6 66 11 , , , cord-003571-upogtny6 66 12 with with IN cord-003571-upogtny6 66 13 direct direct JJ cord-003571-upogtny6 66 14 applications application NNS cord-003571-upogtny6 66 15 to to TO cord-003571-upogtny6 66 16 design design VB cord-003571-upogtny6 66 17 targeted target VBN cord-003571-upogtny6 66 18 intervention intervention NN cord-003571-upogtny6 66 19 strategies strategy NNS cord-003571-upogtny6 66 20 . . . cord-003571-upogtny6 67 1 In in IN cord-003571-upogtny6 67 2 the the DT cord-003571-upogtny6 67 3 present present JJ cord-003571-upogtny6 67 4 issue issue NN cord-003571-upogtny6 67 5 , , , cord-003571-upogtny6 67 6 Bengtsson Bengtsson NNP cord-003571-upogtny6 67 7 et et NNP cord-003571-upogtny6 67 8 al al NNP cord-003571-upogtny6 67 9 . . . cord-003571-upogtny6 68 1 ( ( -LRB- cord-003571-upogtny6 68 2 13 13 CD cord-003571-upogtny6 68 3 ) ) -RRB- cord-003571-upogtny6 68 4 explored explore VBD cord-003571-upogtny6 68 5 the the DT cord-003571-upogtny6 68 6 role role NN cord-003571-upogtny6 68 7 of of IN cord-003571-upogtny6 68 8 social social JJ cord-003571-upogtny6 68 9 class class NN cord-003571-upogtny6 68 10 on on IN cord-003571-upogtny6 68 11 pandemic pandemic JJ cord-003571-upogtny6 68 12 mortality mortality NN cord-003571-upogtny6 68 13 by by IN cord-003571-upogtny6 68 14 linking link VBG cord-003571-upogtny6 68 15 individual individual JJ cord-003571-upogtny6 68 16 death death NN cord-003571-upogtny6 68 17 records record NNS cord-003571-upogtny6 68 18 with with IN cord-003571-upogtny6 68 19 historical historical JJ cord-003571-upogtny6 68 20 census census NN cord-003571-upogtny6 68 21 data datum NNS cord-003571-upogtny6 68 22 on on IN cord-003571-upogtny6 68 23 occupation occupation NN cord-003571-upogtny6 68 24 in in IN cord-003571-upogtny6 68 25 a a DT cord-003571-upogtny6 68 26 powerful powerful JJ cord-003571-upogtny6 68 27 study study NN cord-003571-upogtny6 68 28 that that WDT cord-003571-upogtny6 68 29 captured capture VBD cord-003571-upogtny6 68 30 the the DT cord-003571-upogtny6 68 31 entire entire JJ cord-003571-upogtny6 68 32 Swedish swedish JJ cord-003571-upogtny6 68 33 population population NN cord-003571-upogtny6 68 34 . . . cord-003571-upogtny6 69 1 The the DT cord-003571-upogtny6 69 2 authors author NNS cord-003571-upogtny6 69 3 found find VBD cord-003571-upogtny6 69 4 that that IN cord-003571-upogtny6 69 5 low low RB cord-003571-upogtny6 69 6 - - HYPH cord-003571-upogtny6 69 7 skilled skilled JJ cord-003571-upogtny6 69 8 or or CC cord-003571-upogtny6 69 9 unskilled unskilled JJ cord-003571-upogtny6 69 10 adults adult NNS cord-003571-upogtny6 69 11 had have VBD cord-003571-upogtny6 69 12 higher high JJR cord-003571-upogtny6 69 13 death death NN cord-003571-upogtny6 69 14 rates rate NNS cord-003571-upogtny6 69 15 than than IN cord-003571-upogtny6 69 16 did do VBD cord-003571-upogtny6 69 17 more more JJR cord-003571-upogtny6 69 18 skilled skilled JJ cord-003571-upogtny6 69 19 workers worker NNS cord-003571-upogtny6 69 20 during during IN cord-003571-upogtny6 69 21 the the DT cord-003571-upogtny6 69 22 pandemic pandemic NN cord-003571-upogtny6 69 23 period period NN cord-003571-upogtny6 69 24 relative relative JJ cord-003571-upogtny6 69 25 to to IN cord-003571-upogtny6 69 26 prepandemic prepandemic JJ cord-003571-upogtny6 69 27 years year NNS cord-003571-upogtny6 69 28 , , , cord-003571-upogtny6 69 29 whereas whereas IN cord-003571-upogtny6 69 30 farmers farmer NNS cord-003571-upogtny6 69 31 ( ( -LRB- cord-003571-upogtny6 69 32 especially especially RB cord-003571-upogtny6 69 33 men man NNS cord-003571-upogtny6 69 34 ) ) -RRB- cord-003571-upogtny6 69 35 fared fare VBD cord-003571-upogtny6 69 36 particularly particularly RB cord-003571-upogtny6 69 37 well well RB cord-003571-upogtny6 69 38 . . . cord-003571-upogtny6 70 1 Social social JJ cord-003571-upogtny6 70 2 differences difference NNS cord-003571-upogtny6 70 3 tended tend VBD cord-003571-upogtny6 70 4 to to TO cord-003571-upogtny6 70 5 be be VB cord-003571-upogtny6 70 6 smaller small JJR cord-003571-upogtny6 70 7 in in IN cord-003571-upogtny6 70 8 women woman NNS cord-003571-upogtny6 70 9 , , , cord-003571-upogtny6 70 10 and and CC cord-003571-upogtny6 70 11 there there EX cord-003571-upogtny6 70 12 was be VBD cord-003571-upogtny6 70 13 no no DT cord-003571-upogtny6 70 14 clear clear JJ cord-003571-upogtny6 70 15 gradient gradient NN cord-003571-upogtny6 70 16 between between IN cord-003571-upogtny6 70 17 social social JJ cord-003571-upogtny6 70 18 class class NN cord-003571-upogtny6 70 19 and and CC cord-003571-upogtny6 70 20 mortality mortality NN cord-003571-upogtny6 70 21 . . . cord-003571-upogtny6 71 1 The the DT cord-003571-upogtny6 71 2 authors author NNS cord-003571-upogtny6 71 3 hypothesized hypothesize VBD cord-003571-upogtny6 71 4 that that IN cord-003571-upogtny6 71 5 these these DT cord-003571-upogtny6 71 6 social social JJ cord-003571-upogtny6 71 7 differences difference NNS cord-003571-upogtny6 71 8 were be VBD cord-003571-upogtny6 71 9 linked link VBN cord-003571-upogtny6 71 10 to to IN cord-003571-upogtny6 71 11 differential differential JJ cord-003571-upogtny6 71 12 crowding crowding NN cord-003571-upogtny6 71 13 in in IN cord-003571-upogtny6 71 14 the the DT cord-003571-upogtny6 71 15 workplace workplace NN cord-003571-upogtny6 71 16 ( ( -LRB- cord-003571-upogtny6 71 17 hence hence RB cord-003571-upogtny6 71 18 an an DT cord-003571-upogtny6 71 19 effect effect NN cord-003571-upogtny6 71 20 on on IN cord-003571-upogtny6 71 21 transmission transmission NN cord-003571-upogtny6 71 22 ) ) -RRB- cord-003571-upogtny6 71 23 rather rather RB cord-003571-upogtny6 71 24 than than IN cord-003571-upogtny6 71 25 differences difference NNS cord-003571-upogtny6 71 26 in in IN cord-003571-upogtny6 71 27 income income NN cord-003571-upogtny6 71 28 or or CC cord-003571-upogtny6 71 29 nutrition nutrition NN cord-003571-upogtny6 71 30 . . . cord-003571-upogtny6 72 1 This this DT cord-003571-upogtny6 72 2 is be VBZ cord-003571-upogtny6 72 3 a a DT cord-003571-upogtny6 72 4 topical topical JJ cord-003571-upogtny6 72 5 issue issue NN cord-003571-upogtny6 72 6 because because IN cord-003571-upogtny6 72 7 the the DT cord-003571-upogtny6 72 8 effects effect NNS cord-003571-upogtny6 72 9 of of IN cord-003571-upogtny6 72 10 socioeconomic socioeconomic JJ cord-003571-upogtny6 72 11 status status NN cord-003571-upogtny6 72 12 and and CC cord-003571-upogtny6 72 13 baseline baseline JJ cord-003571-upogtny6 72 14 health health NN cord-003571-upogtny6 72 15 on on IN cord-003571-upogtny6 72 16 influenza influenza NN cord-003571-upogtny6 72 17 mortality mortality NN cord-003571-upogtny6 72 18 are be VBP cord-003571-upogtny6 72 19 still still RB cord-003571-upogtny6 72 20 debated debate VBN cord-003571-upogtny6 72 21 today today NN cord-003571-upogtny6 72 22 ( ( -LRB- cord-003571-upogtny6 72 23 24 24 CD cord-003571-upogtny6 72 24 ) ) -RRB- cord-003571-upogtny6 72 25 . . . cord-003571-upogtny6 73 1 Researchers researcher NNS cord-003571-upogtny6 73 2 have have VBP cord-003571-upogtny6 73 3 long long RB cord-003571-upogtny6 73 4 thought think VBN cord-003571-upogtny6 73 5 that that IN cord-003571-upogtny6 73 6 the the DT cord-003571-upogtny6 73 7 1918 1918 CD cord-003571-upogtny6 73 8 pandemic pandemic NN cord-003571-upogtny6 73 9 could could MD cord-003571-upogtny6 73 10 have have VB cord-003571-upogtny6 73 11 affected affect VBN cord-003571-upogtny6 73 12 birth birth NN cord-003571-upogtny6 73 13 rates rate NNS cord-003571-upogtny6 73 14 ( ( -LRB- cord-003571-upogtny6 73 15 25 25 CD cord-003571-upogtny6 73 16 ) ) -RRB- cord-003571-upogtny6 73 17 because because IN cord-003571-upogtny6 73 18 of of IN cord-003571-upogtny6 73 19 the the DT cord-003571-upogtny6 73 20 large large JJ cord-003571-upogtny6 73 21 impact impact NN cord-003571-upogtny6 73 22 of of IN cord-003571-upogtny6 73 23 this this DT cord-003571-upogtny6 73 24 event event NN cord-003571-upogtny6 73 25 on on IN cord-003571-upogtny6 73 26 young young JJ cord-003571-upogtny6 73 27 adult adult NN cord-003571-upogtny6 73 28 mortality mortality NN cord-003571-upogtny6 73 29 , , , cord-003571-upogtny6 73 30 the the DT cord-003571-upogtny6 73 31 increased increase VBN cord-003571-upogtny6 73 32 risk risk NN cord-003571-upogtny6 73 33 of of IN cord-003571-upogtny6 73 34 severe severe JJ cord-003571-upogtny6 73 35 flu flu NN cord-003571-upogtny6 73 36 outcomes outcome NNS cord-003571-upogtny6 73 37 during during IN cord-003571-upogtny6 73 38 pregnancy pregnancy NN cord-003571-upogtny6 73 39 , , , cord-003571-upogtny6 73 40 and and CC cord-003571-upogtny6 73 41 a a DT cord-003571-upogtny6 73 42 possible possible JJ cord-003571-upogtny6 73 43 association association NN cord-003571-upogtny6 73 44 between between IN cord-003571-upogtny6 73 45 influenza influenza NN cord-003571-upogtny6 73 46 infection infection NN cord-003571-upogtny6 73 47 and and CC cord-003571-upogtny6 73 48 miscarriage miscarriage NN cord-003571-upogtny6 73 49 . . . cord-003571-upogtny6 74 1 Two two CD cord-003571-upogtny6 74 2 papers paper NNS cord-003571-upogtny6 74 3 in in IN cord-003571-upogtny6 74 4 this this DT cord-003571-upogtny6 74 5 issue issue NN cord-003571-upogtny6 74 6 address address VBP cord-003571-upogtny6 74 7 the the DT cord-003571-upogtny6 74 8 topic topic NN cord-003571-upogtny6 74 9 of of IN cord-003571-upogtny6 74 10 natality natality NN cord-003571-upogtny6 74 11 ( ( -LRB- cord-003571-upogtny6 74 12 14 14 CD cord-003571-upogtny6 74 13 , , , cord-003571-upogtny6 74 14 15 15 CD cord-003571-upogtny6 74 15 ) ) -RRB- cord-003571-upogtny6 74 16 . . . cord-003571-upogtny6 75 1 Key key JJ cord-003571-upogtny6 75 2 questions question NNS cord-003571-upogtny6 75 3 here here RB cord-003571-upogtny6 75 4 include include VBP cord-003571-upogtny6 75 5 the the DT cord-003571-upogtny6 75 6 trimester trimester NN cord-003571-upogtny6 75 7 of of IN cord-003571-upogtny6 75 8 pregnancy pregnancy NN cord-003571-upogtny6 75 9 during during IN cord-003571-upogtny6 75 10 which which WDT cord-003571-upogtny6 75 11 the the DT cord-003571-upogtny6 75 12 risk risk NN cord-003571-upogtny6 75 13 of of IN cord-003571-upogtny6 75 14 death death NN cord-003571-upogtny6 75 15 is be VBZ cord-003571-upogtny6 75 16 highest high JJS cord-003571-upogtny6 75 17 for for IN cord-003571-upogtny6 75 18 the the DT cord-003571-upogtny6 75 19 mother mother NN cord-003571-upogtny6 75 20 and/or and/or CC cord-003571-upogtny6 75 21 the the DT cord-003571-upogtny6 75 22 unborn unborn JJ cord-003571-upogtny6 75 23 child child NN cord-003571-upogtny6 75 24 and and CC cord-003571-upogtny6 75 25 the the DT cord-003571-upogtny6 75 26 impact impact NN cord-003571-upogtny6 75 27 of of IN cord-003571-upogtny6 75 28 influenza influenza NN cord-003571-upogtny6 75 29 on on IN cord-003571-upogtny6 75 30 ( ( -LRB- cord-003571-upogtny6 75 31 increased increase VBN cord-003571-upogtny6 75 32 ) ) -RRB- cord-003571-upogtny6 75 33 stillbirths stillbirth NNS cord-003571-upogtny6 75 34 and and CC cord-003571-upogtny6 75 35 ( ( -LRB- cord-003571-upogtny6 75 36 decreased decrease VBD cord-003571-upogtny6 75 37 ) ) -RRB- cord-003571-upogtny6 75 38 live live JJ cord-003571-upogtny6 75 39 births birth NNS cord-003571-upogtny6 75 40 . . . cord-003571-upogtny6 76 1 The the DT cord-003571-upogtny6 76 2 duration duration NN cord-003571-upogtny6 76 3 of of IN cord-003571-upogtny6 76 4 the the DT cord-003571-upogtny6 76 5 pandemic pandemic NN cord-003571-upogtny6 76 6 effect effect NN cord-003571-upogtny6 76 7 on on IN cord-003571-upogtny6 76 8 natality natality NN cord-003571-upogtny6 76 9 is be VBZ cord-003571-upogtny6 76 10 also also RB cord-003571-upogtny6 76 11 important important JJ cord-003571-upogtny6 76 12 because because IN cord-003571-upogtny6 76 13 it -PRON- PRP cord-003571-upogtny6 76 14 informs inform VBZ cord-003571-upogtny6 76 15 the the DT cord-003571-upogtny6 76 16 biological biological JJ cord-003571-upogtny6 76 17 mechanism mechanism NN cord-003571-upogtny6 76 18 at at IN cord-003571-upogtny6 76 19 play play NN cord-003571-upogtny6 76 20 . . . cord-003571-upogtny6 77 1 If if IN cord-003571-upogtny6 77 2 influenza influenza NN cord-003571-upogtny6 77 3 impacts impact VBZ cord-003571-upogtny6 77 4 the the DT cord-003571-upogtny6 77 5 probability probability NN cord-003571-upogtny6 77 6 of of IN cord-003571-upogtny6 77 7 conception conception NN cord-003571-upogtny6 77 8 or or CC cord-003571-upogtny6 77 9 fetal fetal JJ cord-003571-upogtny6 77 10 deaths death NNS cord-003571-upogtny6 77 11 , , , cord-003571-upogtny6 77 12 one one PRP cord-003571-upogtny6 77 13 would would MD cord-003571-upogtny6 77 14 expect expect VB cord-003571-upogtny6 77 15 a a DT cord-003571-upogtny6 77 16 temporary temporary JJ cord-003571-upogtny6 77 17 natality natality NN cord-003571-upogtny6 77 18 drop drop NN cord-003571-upogtny6 77 19 in in IN cord-003571-upogtny6 77 20 the the DT cord-003571-upogtny6 77 21 aftermath aftermath NN cord-003571-upogtny6 77 22 of of IN cord-003571-upogtny6 77 23 the the DT cord-003571-upogtny6 77 24 pandemic pandemic NN cord-003571-upogtny6 77 25 , , , cord-003571-upogtny6 77 26 followed follow VBN cord-003571-upogtny6 77 27 by by IN cord-003571-upogtny6 77 28 a a DT cord-003571-upogtny6 77 29 rebound rebound NN cord-003571-upogtny6 77 30 in in IN cord-003571-upogtny6 77 31 births birth NNS cord-003571-upogtny6 77 32 a a DT cord-003571-upogtny6 77 33 few few JJ cord-003571-upogtny6 77 34 months month NNS cord-003571-upogtny6 77 35 later later RB cord-003571-upogtny6 77 36 . . . cord-003571-upogtny6 78 1 In in IN cord-003571-upogtny6 78 2 contrast contrast NN cord-003571-upogtny6 78 3 , , , cord-003571-upogtny6 78 4 a a DT cord-003571-upogtny6 78 5 high high JJ cord-003571-upogtny6 78 6 mortality mortality NN cord-003571-upogtny6 78 7 rate rate NN cord-003571-upogtny6 78 8 among among IN cord-003571-upogtny6 78 9 young young JJ cord-003571-upogtny6 78 10 women woman NNS cord-003571-upogtny6 78 11 of of IN cord-003571-upogtny6 78 12 childbearing childbeare VBG cord-003571-upogtny6 78 13 age age NN cord-003571-upogtny6 78 14 due due JJ cord-003571-upogtny6 78 15 to to IN cord-003571-upogtny6 78 16 influenza influenza NN cord-003571-upogtny6 78 17 infection infection NN cord-003571-upogtny6 78 18 would would MD cord-003571-upogtny6 78 19 result result VB cord-003571-upogtny6 78 20 in in IN cord-003571-upogtny6 78 21 a a DT cord-003571-upogtny6 78 22 long long RB cord-003571-upogtny6 78 23 - - HYPH cord-003571-upogtny6 78 24 lasting last VBG cord-003571-upogtny6 78 25 natality natality NN cord-003571-upogtny6 78 26 trough trough NN cord-003571-upogtny6 78 27 . . . cord-003571-upogtny6 79 1 Dahal Dahal NNP cord-003571-upogtny6 79 2 et et FW cord-003571-upogtny6 79 3 al al NNP cord-003571-upogtny6 79 4 . . . cord-003571-upogtny6 80 1 ( ( -LRB- cord-003571-upogtny6 80 2 14 14 CD cord-003571-upogtny6 80 3 ) ) -RRB- cord-003571-upogtny6 80 4 explored explore VBD cord-003571-upogtny6 80 5 these these DT cord-003571-upogtny6 80 6 questions question NNS cord-003571-upogtny6 80 7 using use VBG cord-003571-upogtny6 80 8 individual individual JJ cord-003571-upogtny6 80 9 birth birth NN cord-003571-upogtny6 80 10 and and CC cord-003571-upogtny6 80 11 death death NN cord-003571-upogtny6 80 12 certificates certificate NNS cord-003571-upogtny6 80 13 from from IN cord-003571-upogtny6 80 14 Arizona Arizona NNP cord-003571-upogtny6 80 15 , , , cord-003571-upogtny6 80 16 where where WRB cord-003571-upogtny6 80 17 there there EX cord-003571-upogtny6 80 18 was be VBD cord-003571-upogtny6 80 19 a a DT cord-003571-upogtny6 80 20 drop drop NN cord-003571-upogtny6 80 21 in in IN cord-003571-upogtny6 80 22 natality natality NNP cord-003571-upogtny6 80 23 9 9 CD cord-003571-upogtny6 80 24 - - SYM cord-003571-upogtny6 80 25 11 11 CD cord-003571-upogtny6 80 26 months month NNS cord-003571-upogtny6 80 27 after after IN cord-003571-upogtny6 80 28 pandemic pandemic NN cord-003571-upogtny6 80 29 mortality mortality NN cord-003571-upogtny6 80 30 peaked peak VBD cord-003571-upogtny6 80 31 . . . cord-003571-upogtny6 81 1 This this DT cord-003571-upogtny6 81 2 was be VBD cord-003571-upogtny6 81 3 a a DT cord-003571-upogtny6 81 4 temporary temporary JJ cord-003571-upogtny6 81 5 depletion depletion NN cord-003571-upogtny6 81 6 , , , cord-003571-upogtny6 81 7 consistent consistent JJ cord-003571-upogtny6 81 8 with with IN cord-003571-upogtny6 81 9 a a DT cord-003571-upogtny6 81 10 detrimental detrimental JJ cord-003571-upogtny6 81 11 effect effect NN cord-003571-upogtny6 81 12 of of IN cord-003571-upogtny6 81 13 influenza influenza NN cord-003571-upogtny6 81 14 early early RB cord-003571-upogtny6 81 15 in in IN cord-003571-upogtny6 81 16 pregnancy pregnancy NN cord-003571-upogtny6 81 17 . . . cord-003571-upogtny6 82 1 In in IN cord-003571-upogtny6 82 2 a a DT cord-003571-upogtny6 82 3 larger large JJR cord-003571-upogtny6 82 4 study study NN cord-003571-upogtny6 82 5 of of IN cord-003571-upogtny6 82 6 populationlevel populationlevel NNP cord-003571-upogtny6 82 7 vital vital JJ cord-003571-upogtny6 82 8 statistics statistic NNS cord-003571-upogtny6 82 9 in in IN cord-003571-upogtny6 82 10 US US NNP cord-003571-upogtny6 82 11 states state NNS cord-003571-upogtny6 82 12 , , , cord-003571-upogtny6 82 13 Chandra Chandra NNP cord-003571-upogtny6 82 14 et et NNP cord-003571-upogtny6 82 15 al al NNP cord-003571-upogtny6 82 16 . . . cord-003571-upogtny6 83 1 ( ( -LRB- cord-003571-upogtny6 83 2 15 15 CD cord-003571-upogtny6 83 3 ) ) -RRB- cord-003571-upogtny6 83 4 found find VBD cord-003571-upogtny6 83 5 a a DT cord-003571-upogtny6 83 6 10 10 CD cord-003571-upogtny6 83 7 % % NN cord-003571-upogtny6 83 8 drop drop NN cord-003571-upogtny6 83 9 9 9 CD cord-003571-upogtny6 83 10 - - SYM cord-003571-upogtny6 83 11 10 10 CD cord-003571-upogtny6 83 12 months month NNS cord-003571-upogtny6 83 13 after after IN cord-003571-upogtny6 83 14 peak peak NN cord-003571-upogtny6 83 15 influenza influenza NN cord-003571-upogtny6 83 16 mortality mortality NN cord-003571-upogtny6 83 17 , , , cord-003571-upogtny6 83 18 which which WDT cord-003571-upogtny6 83 19 they -PRON- PRP cord-003571-upogtny6 83 20 ascribe ascribe VBP cord-003571-upogtny6 83 21 to to IN cord-003571-upogtny6 83 22 a a DT cord-003571-upogtny6 83 23 drop drop NN cord-003571-upogtny6 83 24 in in IN cord-003571-upogtny6 83 25 conception conception NN cord-003571-upogtny6 83 26 during during IN cord-003571-upogtny6 83 27 the the DT cord-003571-upogtny6 83 28 period period NN cord-003571-upogtny6 83 29 of of IN cord-003571-upogtny6 83 30 intense intense JJ cord-003571-upogtny6 83 31 pandemic pandemic NN cord-003571-upogtny6 83 32 activity activity NN cord-003571-upogtny6 83 33 . . . cord-003571-upogtny6 84 1 They -PRON- PRP cord-003571-upogtny6 84 2 also also RB cord-003571-upogtny6 84 3 found find VBD cord-003571-upogtny6 84 4 a a DT cord-003571-upogtny6 84 5 natality natality NN cord-003571-upogtny6 84 6 drop drop NN cord-003571-upogtny6 84 7 in in IN cord-003571-upogtny6 84 8 the the DT cord-003571-upogtny6 84 9 3 3 CD cord-003571-upogtny6 84 10 months month NNS cord-003571-upogtny6 84 11 after after IN cord-003571-upogtny6 84 12 peak peak NN cord-003571-upogtny6 84 13 mortality mortality NN cord-003571-upogtny6 84 14 , , , cord-003571-upogtny6 84 15 which which WDT cord-003571-upogtny6 84 16 they -PRON- PRP cord-003571-upogtny6 84 17 linked link VBD cord-003571-upogtny6 84 18 to to IN cord-003571-upogtny6 84 19 excess excess JJ cord-003571-upogtny6 84 20 preterm preterm JJ cord-003571-upogtny6 84 21 births birth NNS cord-003571-upogtny6 84 22 and and CC cord-003571-upogtny6 84 23 stillbirths stillbirth NNS cord-003571-upogtny6 84 24 due due JJ cord-003571-upogtny6 84 25 to to IN cord-003571-upogtny6 84 26 influenza influenza NN cord-003571-upogtny6 84 27 infections infection NNS cord-003571-upogtny6 84 28 in in IN cord-003571-upogtny6 84 29 the the DT cord-003571-upogtny6 84 30 last last JJ cord-003571-upogtny6 84 31 trimester trimester NN cord-003571-upogtny6 84 32 . . . cord-003571-upogtny6 85 1 Interestingly interestingly RB cord-003571-upogtny6 85 2 , , , cord-003571-upogtny6 85 3 these these DT cord-003571-upogtny6 85 4 patterns pattern NNS cord-003571-upogtny6 85 5 were be VBD cord-003571-upogtny6 85 6 also also RB cord-003571-upogtny6 85 7 found find VBN cord-003571-upogtny6 85 8 in in IN cord-003571-upogtny6 85 9 the the DT cord-003571-upogtny6 85 10 aftermath aftermath NN cord-003571-upogtny6 85 11 of of IN cord-003571-upogtny6 85 12 the the DT cord-003571-upogtny6 85 13 1920 1920 CD cord-003571-upogtny6 85 14 influenza influenza NN cord-003571-upogtny6 85 15 pandemic pandemic NN cord-003571-upogtny6 85 16 wave wave NN cord-003571-upogtny6 85 17 , , , cord-003571-upogtny6 85 18 albeit albeit IN cord-003571-upogtny6 85 19 with with IN cord-003571-upogtny6 85 20 a a DT cord-003571-upogtny6 85 21 less less RBR cord-003571-upogtny6 85 22 pronounced pronounced JJ cord-003571-upogtny6 85 23 effect effect NN cord-003571-upogtny6 85 24 . . . cord-003571-upogtny6 86 1 One one CD cord-003571-upogtny6 86 2 reason reason NN cord-003571-upogtny6 86 3 we -PRON- PRP cord-003571-upogtny6 86 4 still still RB cord-003571-upogtny6 86 5 look look VBP cord-003571-upogtny6 86 6 back back RB cord-003571-upogtny6 86 7 at at IN cord-003571-upogtny6 86 8 the the DT cord-003571-upogtny6 86 9 1918 1918 CD cord-003571-upogtny6 86 10 pandemic pandemic NN cord-003571-upogtny6 86 11 100 100 CD cord-003571-upogtny6 86 12 years year NNS cord-003571-upogtny6 86 13 later later RB cord-003571-upogtny6 86 14 is be VBZ cord-003571-upogtny6 86 15 because because IN cord-003571-upogtny6 86 16 doing do VBG cord-003571-upogtny6 86 17 so so RB cord-003571-upogtny6 86 18 will will MD cord-003571-upogtny6 86 19 make make VB cord-003571-upogtny6 86 20 us -PRON- PRP cord-003571-upogtny6 86 21 better well RBR cord-003571-upogtny6 86 22 able able JJ cord-003571-upogtny6 86 23 to to TO cord-003571-upogtny6 86 24 prepare prepare VB cord-003571-upogtny6 86 25 for for IN cord-003571-upogtny6 86 26 the the DT cord-003571-upogtny6 86 27 future future NN cord-003571-upogtny6 86 28 . . . cord-003571-upogtny6 87 1 The the DT cord-003571-upogtny6 87 2 last last JJ cord-003571-upogtny6 87 3 2 2 CD cord-003571-upogtny6 87 4 articles article NNS cord-003571-upogtny6 87 5 of of IN cord-003571-upogtny6 87 6 this this DT cord-003571-upogtny6 87 7 collection collection NN cord-003571-upogtny6 87 8 are be VBP cord-003571-upogtny6 87 9 focused focus VBN cord-003571-upogtny6 87 10 on on IN cord-003571-upogtny6 87 11 preparedness preparedness NN cord-003571-upogtny6 87 12 for for IN cord-003571-upogtny6 87 13 future future JJ cord-003571-upogtny6 87 14 pandemic pandemic NN cord-003571-upogtny6 87 15 threats threat NNS cord-003571-upogtny6 87 16 ( ( -LRB- cord-003571-upogtny6 87 17 16 16 CD cord-003571-upogtny6 87 18 , , , cord-003571-upogtny6 87 19 17 17 CD cord-003571-upogtny6 87 20 ) ) -RRB- cord-003571-upogtny6 87 21 , , , cord-003571-upogtny6 87 22 building build VBG cord-003571-upogtny6 87 23 on on IN cord-003571-upogtny6 87 24 the the DT cord-003571-upogtny6 87 25 lessons lesson NNS cord-003571-upogtny6 87 26 learned learn VBN cord-003571-upogtny6 87 27 in in IN cord-003571-upogtny6 87 28 1918 1918 CD cord-003571-upogtny6 87 29 and and CC cord-003571-upogtny6 87 30 later later JJ cord-003571-upogtny6 87 31 pandemics pandemic NNS cord-003571-upogtny6 87 32 , , , cord-003571-upogtny6 87 33 and and CC cord-003571-upogtny6 87 34 on on IN cord-003571-upogtny6 87 35 new new JJ cord-003571-upogtny6 87 36 tools tool NNS cord-003571-upogtny6 87 37 to to TO cord-003571-upogtny6 87 38 protect protect VB cord-003571-upogtny6 87 39 populations population NNS cord-003571-upogtny6 87 40 , , , cord-003571-upogtny6 87 41 including include VBG cord-003571-upogtny6 87 42 the the DT cord-003571-upogtny6 87 43 very very RB cord-003571-upogtny6 87 44 active active JJ cord-003571-upogtny6 87 45 ( ( -LRB- cord-003571-upogtny6 87 46 but but CC cord-003571-upogtny6 87 47 still still RB cord-003571-upogtny6 87 48 elusive elusive JJ cord-003571-upogtny6 87 49 ) ) -RRB- cord-003571-upogtny6 87 50 topic topic NN cord-003571-upogtny6 87 51 of of IN cord-003571-upogtny6 87 52 universal universal JJ cord-003571-upogtny6 87 53 influenza influenza NN cord-003571-upogtny6 87 54 vaccines vaccine NNS cord-003571-upogtny6 87 55 . . . cord-003571-upogtny6 88 1 Jester Jester NNP cord-003571-upogtny6 88 2 et et NNP cord-003571-upogtny6 88 3 al al NNP cord-003571-upogtny6 88 4 . . NNP cord-003571-upogtny6 88 5 painted paint VBD cord-003571-upogtny6 88 6 an an DT cord-003571-upogtny6 88 7 optimistic optimistic JJ cord-003571-upogtny6 88 8 picture picture NN cord-003571-upogtny6 88 9 of of IN cord-003571-upogtny6 88 10 progress progress NN cord-003571-upogtny6 88 11 made make VBN cord-003571-upogtny6 88 12 in in IN cord-003571-upogtny6 88 13 influenza influenza NN cord-003571-upogtny6 88 14 surveillance surveillance NN cord-003571-upogtny6 88 15 domestically domestically RB cord-003571-upogtny6 88 16 and and CC cord-003571-upogtny6 88 17 internationally internationally RB cord-003571-upogtny6 88 18 , , , cord-003571-upogtny6 88 19 antiviral antiviral JJ cord-003571-upogtny6 88 20 treatments treatment NNS cord-003571-upogtny6 88 21 , , , cord-003571-upogtny6 88 22 and and CC cord-003571-upogtny6 88 23 robustness robustness NN cord-003571-upogtny6 88 24 in in IN cord-003571-upogtny6 88 25 the the DT cord-003571-upogtny6 88 26 infrastructure infrastructure NN cord-003571-upogtny6 88 27 for for IN cord-003571-upogtny6 88 28 vaccine vaccine NN cord-003571-upogtny6 88 29 production production NN cord-003571-upogtny6 88 30 ( ( -LRB- cord-003571-upogtny6 88 31 16 16 CD cord-003571-upogtny6 88 32 ) ) -RRB- cord-003571-upogtny6 88 33 . . . cord-003571-upogtny6 89 1 Epstein Epstein NNP cord-003571-upogtny6 89 2 reviewed review VBD cord-003571-upogtny6 89 3 the the DT cord-003571-upogtny6 89 4 progress progress NN cord-003571-upogtny6 89 5 of of IN cord-003571-upogtny6 89 6 the the DT cord-003571-upogtny6 89 7 development development NN cord-003571-upogtny6 89 8 of of IN cord-003571-upogtny6 89 9 a a DT cord-003571-upogtny6 89 10 broadly broadly RB cord-003571-upogtny6 89 11 cross cross JJ cord-003571-upogtny6 89 12 - - JJ cord-003571-upogtny6 89 13 protective protective JJ cord-003571-upogtny6 89 14 flu flu NN cord-003571-upogtny6 89 15 vaccine vaccine NN cord-003571-upogtny6 89 16 , , , cord-003571-upogtny6 89 17 focused focus VBD cord-003571-upogtny6 89 18 on on IN cord-003571-upogtny6 89 19 conserved conserved JJ cord-003571-upogtny6 89 20 parts part NNS cord-003571-upogtny6 89 21 of of IN cord-003571-upogtny6 89 22 the the DT cord-003571-upogtny6 89 23 influenza influenza NN cord-003571-upogtny6 89 24 virus virus NN cord-003571-upogtny6 89 25 , , , cord-003571-upogtny6 89 26 such such JJ cord-003571-upogtny6 89 27 as as IN cord-003571-upogtny6 89 28 the the DT cord-003571-upogtny6 89 29 matrix matrix NN cord-003571-upogtny6 89 30 protein protein NN cord-003571-upogtny6 89 31 , , , cord-003571-upogtny6 89 32 nucleoprotein nucleoprotein NNP cord-003571-upogtny6 89 33 , , , cord-003571-upogtny6 89 34 the the DT cord-003571-upogtny6 89 35 hemagglutinin hemagglutinin NN cord-003571-upogtny6 89 36 stem stem NN cord-003571-upogtny6 89 37 , , , cord-003571-upogtny6 89 38 and and CC cord-003571-upogtny6 89 39 various various JJ cord-003571-upogtny6 89 40 cocktail cocktail NN cord-003571-upogtny6 89 41 combinations combination NNS cord-003571-upogtny6 89 42 ( ( -LRB- cord-003571-upogtny6 89 43 17 17 CD cord-003571-upogtny6 89 44 ) ) -RRB- cord-003571-upogtny6 89 45 . . . cord-003571-upogtny6 90 1 These these DT cord-003571-upogtny6 90 2 vaccines vaccine NNS cord-003571-upogtny6 90 3 offer offer VBP cord-003571-upogtny6 90 4 promising promise VBG cord-003571-upogtny6 90 5 broad broad JJ cord-003571-upogtny6 90 6 protective protective JJ cord-003571-upogtny6 90 7 effects effect NNS cord-003571-upogtny6 90 8 against against IN cord-003571-upogtny6 90 9 new new JJ cord-003571-upogtny6 90 10 influenza influenza NN cord-003571-upogtny6 90 11 antigenic antigenic JJ cord-003571-upogtny6 90 12 variants variant NNS cord-003571-upogtny6 90 13 and and CC cord-003571-upogtny6 90 14 could could MD cord-003571-upogtny6 90 15 potentially potentially RB cord-003571-upogtny6 90 16 be be VB cord-003571-upogtny6 90 17 used use VBN cord-003571-upogtny6 90 18 in in IN cord-003571-upogtny6 90 19 pandemic pandemic JJ cord-003571-upogtny6 90 20 situations situation NNS cord-003571-upogtny6 90 21 . . . cord-003571-upogtny6 91 1 However however RB cord-003571-upogtny6 91 2 , , , cord-003571-upogtny6 91 3 some some DT cord-003571-upogtny6 91 4 of of IN cord-003571-upogtny6 91 5 the the DT cord-003571-upogtny6 91 6 candidate candidate NN cord-003571-upogtny6 91 7 vaccine vaccine NN cord-003571-upogtny6 91 8 formulations formulation NNS cord-003571-upogtny6 91 9 permit permit VBP cord-003571-upogtny6 91 10 limited limit VBN cord-003571-upogtny6 91 11 viral viral JJ cord-003571-upogtny6 91 12 replication replication NN cord-003571-upogtny6 91 13 and and CC cord-003571-upogtny6 91 14 may may MD cord-003571-upogtny6 91 15 foster foster VB cord-003571-upogtny6 91 16 the the DT cord-003571-upogtny6 91 17 emergence emergence NN cord-003571-upogtny6 91 18 of of IN cord-003571-upogtny6 91 19 escape escape NN cord-003571-upogtny6 91 20 mutants mutant NNS cord-003571-upogtny6 91 21 fit fit VBP cord-003571-upogtny6 91 22 enough enough RB cord-003571-upogtny6 91 23 to to TO cord-003571-upogtny6 91 24 cause cause VB cord-003571-upogtny6 91 25 disease disease NN cord-003571-upogtny6 91 26 . . . cord-003571-upogtny6 92 1 These these DT cord-003571-upogtny6 92 2 features feature NNS cord-003571-upogtny6 92 3 could could MD cord-003571-upogtny6 92 4 have have VB cord-003571-upogtny6 92 5 adverse adverse JJ cord-003571-upogtny6 92 6 epidemiologic epidemiologic JJ cord-003571-upogtny6 92 7 consequences consequence NNS cord-003571-upogtny6 92 8 , , , cord-003571-upogtny6 92 9 and and CC cord-003571-upogtny6 92 10 these these DT cord-003571-upogtny6 92 11 risks risk NNS cord-003571-upogtny6 92 12 need need VBP cord-003571-upogtny6 92 13 to to TO cord-003571-upogtny6 92 14 be be VB cord-003571-upogtny6 92 15 projected project VBN cord-003571-upogtny6 92 16 and and CC cord-003571-upogtny6 92 17 monitored monitor VBN cord-003571-upogtny6 92 18 carefully carefully RB cord-003571-upogtny6 92 19 . . . cord-003571-upogtny6 93 1 The the DT cord-003571-upogtny6 93 2 1918 1918 CD cord-003571-upogtny6 93 3 pandemic pandemic NN cord-003571-upogtny6 93 4 is be VBZ cord-003571-upogtny6 93 5 traditionally traditionally RB cord-003571-upogtny6 93 6 considered consider VBN cord-003571-upogtny6 93 7 a a DT cord-003571-upogtny6 93 8 worst bad JJS cord-003571-upogtny6 93 9 - - HYPH cord-003571-upogtny6 93 10 case case NN cord-003571-upogtny6 93 11 scenario scenario NN cord-003571-upogtny6 93 12 for for IN cord-003571-upogtny6 93 13 pandemic pandemic JJ cord-003571-upogtny6 93 14 preparedness preparedness NN cord-003571-upogtny6 93 15 , , , cord-003571-upogtny6 93 16 but but CC cord-003571-upogtny6 93 17 there there EX cord-003571-upogtny6 93 18 were be VBD cord-003571-upogtny6 93 19 many many JJ cord-003571-upogtny6 93 20 other other JJ cord-003571-upogtny6 93 21 pandemics pandemic NNS cord-003571-upogtny6 93 22 before before IN cord-003571-upogtny6 93 23 1918 1918 CD cord-003571-upogtny6 93 24 about about IN cord-003571-upogtny6 93 25 which which WDT cord-003571-upogtny6 93 26 we -PRON- PRP cord-003571-upogtny6 93 27 know know VBP cord-003571-upogtny6 93 28 very very RB cord-003571-upogtny6 93 29 little little JJ cord-003571-upogtny6 93 30 regarding regard VBG cord-003571-upogtny6 93 31 mortality mortality NN cord-003571-upogtny6 93 32 impact impact NN cord-003571-upogtny6 93 33 , , , cord-003571-upogtny6 93 34 circulating circulate VBG cord-003571-upogtny6 93 35 strains strain NNS cord-003571-upogtny6 93 36 , , , cord-003571-upogtny6 93 37 or or CC cord-003571-upogtny6 93 38 prior prior JJ cord-003571-upogtny6 93 39 immunity immunity NN cord-003571-upogtny6 93 40 . . . cord-003571-upogtny6 94 1 In in IN cord-003571-upogtny6 94 2 fact fact NN cord-003571-upogtny6 94 3 , , , cord-003571-upogtny6 94 4 the the DT cord-003571-upogtny6 94 5 1889 1889 CD cord-003571-upogtny6 94 6 pandemic pandemic NN cord-003571-upogtny6 94 7 has have VBZ cord-003571-upogtny6 94 8 only only RB cord-003571-upogtny6 94 9 recently recently RB cord-003571-upogtny6 94 10 drawn draw VBN cord-003571-upogtny6 94 11 attention attention NN cord-003571-upogtny6 94 12 among among IN cord-003571-upogtny6 94 13 epidemiologists epidemiologist NNS cord-003571-upogtny6 94 14 ( ( -LRB- cord-003571-upogtny6 94 15 26 26 CD cord-003571-upogtny6 94 16 , , , cord-003571-upogtny6 94 17 27 27 CD cord-003571-upogtny6 94 18 ) ) -RRB- cord-003571-upogtny6 94 19 . . . cord-003571-upogtny6 95 1 Most Most JJS cord-003571-upogtny6 95 2 European european JJ cord-003571-upogtny6 95 3 and and CC cord-003571-upogtny6 95 4 North north JJ cord-003571-upogtny6 95 5 American american JJ cord-003571-upogtny6 95 6 countries country NNS cord-003571-upogtny6 95 7 began begin VBD cord-003571-upogtny6 95 8 formal formal JJ cord-003571-upogtny6 95 9 collection collection NN cord-003571-upogtny6 95 10 of of IN cord-003571-upogtny6 95 11 vital vital JJ cord-003571-upogtny6 95 12 statistics statistic NNS cord-003571-upogtny6 95 13 in in IN cord-003571-upogtny6 95 14 the the DT cord-003571-upogtny6 95 15 mid mid NN cord-003571-upogtny6 95 16 - - HYPH cord-003571-upogtny6 95 17 to to IN cord-003571-upogtny6 95 18 - - HYPH cord-003571-upogtny6 95 19 late late JJ cord-003571-upogtny6 95 20 19th 19th JJ cord-003571-upogtny6 95 21 century century NN cord-003571-upogtny6 95 22 , , , cord-003571-upogtny6 95 23 so so IN cord-003571-upogtny6 95 24 that that IN cord-003571-upogtny6 95 25 any any DT cord-003571-upogtny6 95 26 pandemic pandemic NN cord-003571-upogtny6 95 27 predating predate VBG cord-003571-upogtny6 95 28 1850 1850 CD cord-003571-upogtny6 95 29 can can MD cord-003571-upogtny6 95 30 only only RB cord-003571-upogtny6 95 31 be be VB cord-003571-upogtny6 95 32 explored explore VBN cord-003571-upogtny6 95 33 using use VBG cord-003571-upogtny6 95 34 church church NN cord-003571-upogtny6 95 35 or or CC cord-003571-upogtny6 95 36 cemetery cemetery NN cord-003571-upogtny6 95 37 records record NNS cord-003571-upogtny6 95 38 ( ( -LRB- cord-003571-upogtny6 95 39 or or CC cord-003571-upogtny6 95 40 indirectly indirectly RB cord-003571-upogtny6 95 41 through through IN cord-003571-upogtny6 95 42 reconstruction reconstruction NN cord-003571-upogtny6 95 43 of of IN cord-003571-upogtny6 95 44 modern modern JJ cord-003571-upogtny6 95 45 pandemics pandemic NNS cord-003571-upogtny6 95 46 ) ) -RRB- cord-003571-upogtny6 95 47 . . . cord-003571-upogtny6 96 1 Digitization digitization NN cord-003571-upogtny6 96 2 of of IN cord-003571-upogtny6 96 3 historic historic JJ cord-003571-upogtny6 96 4 records record NNS cord-003571-upogtny6 96 5 is be VBZ cord-003571-upogtny6 96 6 time time NN cord-003571-upogtny6 96 7 consuming consume VBG cord-003571-upogtny6 96 8 , , , cord-003571-upogtny6 96 9 data datum NNS cord-003571-upogtny6 96 10 lack lack NN cord-003571-upogtny6 96 11 standardization standardization NN cord-003571-upogtny6 96 12 , , , cord-003571-upogtny6 96 13 and and CC cord-003571-upogtny6 96 14 information information NN cord-003571-upogtny6 96 15 is be VBZ cord-003571-upogtny6 96 16 generally generally RB cord-003571-upogtny6 96 17 limited limit VBN cord-003571-upogtny6 96 18 to to IN cord-003571-upogtny6 96 19 small small JJ cord-003571-upogtny6 96 20 populations population NNS cord-003571-upogtny6 96 21 . . . cord-003571-upogtny6 97 1 Even even RB cord-003571-upogtny6 97 2 with with IN cord-003571-upogtny6 97 3 regard regard NN cord-003571-upogtny6 97 4 to to IN cord-003571-upogtny6 97 5 the the DT cord-003571-upogtny6 97 6 1918 1918 CD cord-003571-upogtny6 97 7 pandemic pandemic NN cord-003571-upogtny6 97 8 , , , cord-003571-upogtny6 97 9 crucial crucial JJ cord-003571-upogtny6 97 10 questions question NNS cord-003571-upogtny6 97 11 may may MD cord-003571-upogtny6 97 12 never never RB cord-003571-upogtny6 97 13 be be VB cord-003571-upogtny6 97 14 answered answer VBN cord-003571-upogtny6 97 15 , , , cord-003571-upogtny6 97 16 including include VBG cord-003571-upogtny6 97 17 which which WDT cord-003571-upogtny6 97 18 specific specific JJ cord-003571-upogtny6 97 19 virus virus NN cord-003571-upogtny6 97 20 ( ( -LRB- cord-003571-upogtny6 97 21 or or CC cord-003571-upogtny6 97 22 even even RB cord-003571-upogtny6 97 23 subtype subtype NN cord-003571-upogtny6 97 24 ) ) -RRB- cord-003571-upogtny6 97 25 circulated circulate VBN cord-003571-upogtny6 97 26 before before IN cord-003571-upogtny6 97 27 1918 1918 CD cord-003571-upogtny6 97 28 and and CC cord-003571-upogtny6 97 29 further far RBR cord-003571-upogtny6 97 30 back back RB cord-003571-upogtny6 97 31 into into IN cord-003571-upogtny6 97 32 the the DT cord-003571-upogtny6 97 33 19th 19th JJ cord-003571-upogtny6 97 34 century century NN cord-003571-upogtny6 97 35 and and CC cord-003571-upogtny6 97 36 what what WP cord-003571-upogtny6 97 37 the the DT cord-003571-upogtny6 97 38 population population NN cord-003571-upogtny6 97 39 immunity immunity NN cord-003571-upogtny6 97 40 profile profile NN cord-003571-upogtny6 97 41 was be VBD cord-003571-upogtny6 97 42 before before IN cord-003571-upogtny6 97 43 the the DT cord-003571-upogtny6 97 44 pandemic pandemic NN cord-003571-upogtny6 97 45 . . . cord-003571-upogtny6 98 1 The the DT cord-003571-upogtny6 98 2 search search NN cord-003571-upogtny6 98 3 for for IN cord-003571-upogtny6 98 4 archival archival JJ cord-003571-upogtny6 98 5 influenza influenza NN cord-003571-upogtny6 98 6 specimens specimen NNS cord-003571-upogtny6 98 7 predating predate VBG cord-003571-upogtny6 98 8 1918 1918 CD cord-003571-upogtny6 98 9 has have VBZ cord-003571-upogtny6 98 10 remained remain VBN cord-003571-upogtny6 98 11 elusive elusive JJ cord-003571-upogtny6 98 12 , , , cord-003571-upogtny6 98 13 and and CC cord-003571-upogtny6 98 14 to to IN cord-003571-upogtny6 98 15 our -PRON- PRP$ cord-003571-upogtny6 98 16 knowledge knowledge NN cord-003571-upogtny6 98 17 no no DT cord-003571-upogtny6 98 18 archived archive VBN cord-003571-upogtny6 98 19 sera sera NNP cord-003571-upogtny6 98 20 exist exist VBP cord-003571-upogtny6 98 21 from from IN cord-003571-upogtny6 98 22 this this DT cord-003571-upogtny6 98 23 period period NN cord-003571-upogtny6 98 24 . . . cord-003571-upogtny6 99 1 In in IN cord-003571-upogtny6 99 2 the the DT cord-003571-upogtny6 99 3 absence absence NN cord-003571-upogtny6 99 4 of of IN cord-003571-upogtny6 99 5 further further JJ cord-003571-upogtny6 99 6 virologic virologic JJ cord-003571-upogtny6 99 7 evidence evidence NN cord-003571-upogtny6 99 8 , , , cord-003571-upogtny6 99 9 our -PRON- PRP$ cord-003571-upogtny6 99 10 understanding understanding NN cord-003571-upogtny6 99 11 of of IN cord-003571-upogtny6 99 12 the the DT cord-003571-upogtny6 99 13 origins origin NNS cord-003571-upogtny6 99 14 of of IN cord-003571-upogtny6 99 15 the the DT cord-003571-upogtny6 99 16 pandemic pandemic NN cord-003571-upogtny6 99 17 is be VBZ cord-003571-upogtny6 99 18 limited limit VBN cord-003571-upogtny6 99 19 to to IN cord-003571-upogtny6 99 20 a a DT cord-003571-upogtny6 99 21 handful handful NN cord-003571-upogtny6 99 22 of of IN cord-003571-upogtny6 99 23 influenza influenza NN cord-003571-upogtny6 99 24 virus virus NN cord-003571-upogtny6 99 25 sequences sequence NNS cord-003571-upogtny6 99 26 collected collect VBN cord-003571-upogtny6 99 27 during during IN cord-003571-upogtny6 99 28 May May NNP cord-003571-upogtny6 99 29 to to IN cord-003571-upogtny6 99 30 November November NNP cord-003571-upogtny6 99 31 1918 1918 CD cord-003571-upogtny6 99 32 and and CC cord-003571-upogtny6 99 33 to to IN cord-003571-upogtny6 99 34 the the DT cord-003571-upogtny6 99 35 epidemiologic epidemiologic JJ cord-003571-upogtny6 99 36 signature signature NN cord-003571-upogtny6 99 37 of of IN cord-003571-upogtny6 99 38 the the DT cord-003571-upogtny6 99 39 1918 1918 CD cord-003571-upogtny6 99 40 virus virus NN cord-003571-upogtny6 99 41 in in IN cord-003571-upogtny6 99 42 different different JJ cord-003571-upogtny6 99 43 populations population NNS cord-003571-upogtny6 99 44 . . . cord-003571-upogtny6 100 1 As as IN cord-003571-upogtny6 100 2 Nelson Nelson NNP cord-003571-upogtny6 100 3 and and CC cord-003571-upogtny6 100 4 Worobey Worobey NNP cord-003571-upogtny6 100 5 noted note VBD cord-003571-upogtny6 100 6 ( ( -LRB- cord-003571-upogtny6 100 7 5 5 CD cord-003571-upogtny6 100 8 ) ) -RRB- cord-003571-upogtny6 100 9 , , , cord-003571-upogtny6 100 10 more more JJR cord-003571-upogtny6 100 11 work work NN cord-003571-upogtny6 100 12 can can MD cord-003571-upogtny6 100 13 be be VB cord-003571-upogtny6 100 14 done do VBN cord-003571-upogtny6 100 15 in in IN cord-003571-upogtny6 100 16 this this DT cord-003571-upogtny6 100 17 area area NN cord-003571-upogtny6 100 18 , , , cord-003571-upogtny6 100 19 particularly particularly RB cord-003571-upogtny6 100 20 to to TO cord-003571-upogtny6 100 21 explore explore VB cord-003571-upogtny6 100 22 the the DT cord-003571-upogtny6 100 23 uracil uracil NN cord-003571-upogtny6 100 24 content content NN cord-003571-upogtny6 100 25 of of IN cord-003571-upogtny6 100 26 post-1918 post-1918 NN cord-003571-upogtny6 100 27 viruses virus NNS cord-003571-upogtny6 100 28 in in IN cord-003571-upogtny6 100 29 different different JJ cord-003571-upogtny6 100 30 hosts host NNS cord-003571-upogtny6 100 31 , , , cord-003571-upogtny6 100 32 reconstruct reconstruct VB cord-003571-upogtny6 100 33 their -PRON- PRP$ cord-003571-upogtny6 100 34 evolutionary evolutionary JJ cord-003571-upogtny6 100 35 trajectories trajectory NNS cord-003571-upogtny6 100 36 , , , cord-003571-upogtny6 100 37 and and CC cord-003571-upogtny6 100 38 better well RBR cord-003571-upogtny6 100 39 characterize characterize VB cord-003571-upogtny6 100 40 host host NN cord-003571-upogtny6 100 41 receptors receptor NNS cord-003571-upogtny6 100 42 and and CC cord-003571-upogtny6 100 43 barriers barrier NNS cord-003571-upogtny6 100 44 to to IN cord-003571-upogtny6 100 45 cross cross NN cord-003571-upogtny6 100 46 - - NNS cord-003571-upogtny6 100 47 species species JJ cord-003571-upogtny6 100 48 jumps jump NNS cord-003571-upogtny6 100 49 . . . cord-003571-upogtny6 101 1 Further further RB cord-003571-upogtny6 101 2 , , , cord-003571-upogtny6 101 3 as as IN cord-003571-upogtny6 101 4 Rice Rice NNP cord-003571-upogtny6 101 5 ( ( -LRB- cord-003571-upogtny6 101 6 8) 8) NNP cord-003571-upogtny6 101 7 and and CC cord-003571-upogtny6 101 8 Dahal Dahal NNP cord-003571-upogtny6 101 9 et et FW cord-003571-upogtny6 101 10 al al NNP cord-003571-upogtny6 101 11 . . . cord-003571-upogtny6 102 1 ( ( -LRB- cord-003571-upogtny6 102 2 14 14 CD cord-003571-upogtny6 102 3 ) ) -RRB- cord-003571-upogtny6 102 4 noted note VBD cord-003571-upogtny6 102 5 , , , cord-003571-upogtny6 102 6 a a DT cord-003571-upogtny6 102 7 systematic systematic JJ cord-003571-upogtny6 102 8 analysis analysis NN cord-003571-upogtny6 102 9 of of IN cord-003571-upogtny6 102 10 the the DT cord-003571-upogtny6 102 11 age age NN cord-003571-upogtny6 102 12 mortality mortality NN cord-003571-upogtny6 102 13 profiles profile NNS cord-003571-upogtny6 102 14 of of IN cord-003571-upogtny6 102 15 the the DT cord-003571-upogtny6 102 16 1918 1918 CD cord-003571-upogtny6 102 17 pandemic pandemic NN cord-003571-upogtny6 102 18 in in IN cord-003571-upogtny6 102 19 a a DT cord-003571-upogtny6 102 20 sample sample NN cord-003571-upogtny6 102 21 of of IN cord-003571-upogtny6 102 22 remote remote JJ cord-003571-upogtny6 102 23 and and CC cord-003571-upogtny6 102 24 wellconnected wellconnected JJ cord-003571-upogtny6 102 25 locations location NNS cord-003571-upogtny6 102 26 would would MD cord-003571-upogtny6 102 27 be be VB cord-003571-upogtny6 102 28 most most RBS cord-003571-upogtny6 102 29 useful useful JJ cord-003571-upogtny6 102 30 , , , cord-003571-upogtny6 102 31 together together RB cord-003571-upogtny6 102 32 with with IN cord-003571-upogtny6 102 33 modeling modeling NN cord-003571-upogtny6 102 34 of of IN cord-003571-upogtny6 102 35 plausible plausible JJ cord-003571-upogtny6 102 36 biological biological JJ cord-003571-upogtny6 102 37 hypotheses hypothesis NNS cord-003571-upogtny6 102 38 and and CC cord-003571-upogtny6 102 39 immune immune JJ cord-003571-upogtny6 102 40 histories history NNS cord-003571-upogtny6 102 41 most most RBS cord-003571-upogtny6 102 42 consistent consistent JJ cord-003571-upogtny6 102 43 with with IN cord-003571-upogtny6 102 44 the the DT cord-003571-upogtny6 102 45 data datum NNS cord-003571-upogtny6 102 46 . . . cord-003571-upogtny6 103 1 databases database NNS cord-003571-upogtny6 103 2 , , , cord-003571-upogtny6 103 3 which which WDT cord-003571-upogtny6 103 4 are be VBP cord-003571-upogtny6 103 5 often often RB cord-003571-upogtny6 103 6 crowdsourced crowdsource VBN cord-003571-upogtny6 103 7 or or CC cord-003571-upogtny6 103 8 maintained maintain VBN cord-003571-upogtny6 103 9 by by IN cord-003571-upogtny6 103 10 state state NN cord-003571-upogtny6 103 11 health health NN cord-003571-upogtny6 103 12 departments department NNS cord-003571-upogtny6 103 13 ( ( -LRB- cord-003571-upogtny6 103 14 14 14 CD cord-003571-upogtny6 103 15 ) ) -RRB- cord-003571-upogtny6 103 16 . . . cord-003571-upogtny6 104 1 Further further JJ cord-003571-upogtny6 104 2 analyses analysis NNS cord-003571-upogtny6 104 3 of of IN cord-003571-upogtny6 104 4 such such JJ cord-003571-upogtny6 104 5 data datum NNS cord-003571-upogtny6 104 6 could could MD cord-003571-upogtny6 104 7 shed shed VB cord-003571-upogtny6 104 8 light light NN cord-003571-upogtny6 104 9 on on IN cord-003571-upogtny6 104 10 the the DT cord-003571-upogtny6 104 11 mortality mortality NN cord-003571-upogtny6 104 12 profile profile NN cord-003571-upogtny6 104 13 of of IN cord-003571-upogtny6 104 14 the the DT cord-003571-upogtny6 104 15 pandemic pandemic NN cord-003571-upogtny6 104 16 in in IN cord-003571-upogtny6 104 17 understudied understudied JJ cord-003571-upogtny6 104 18 locations location NNS cord-003571-upogtny6 104 19 and and CC cord-003571-upogtny6 104 20 would would MD cord-003571-upogtny6 104 21 also also RB cord-003571-upogtny6 104 22 allow allow VB cord-003571-upogtny6 104 23 identification identification NN cord-003571-upogtny6 104 24 of of IN cord-003571-upogtny6 104 25 family family NN cord-003571-upogtny6 104 26 linkage linkage NN cord-003571-upogtny6 104 27 and and CC cord-003571-upogtny6 104 28 host host NN cord-003571-upogtny6 104 29 genetic genetic JJ cord-003571-upogtny6 104 30 risk risk NN cord-003571-upogtny6 104 31 factors factor NNS cord-003571-upogtny6 104 32 , , , cord-003571-upogtny6 104 33 which which WDT cord-003571-upogtny6 104 34 could could MD cord-003571-upogtny6 104 35 be be VB cord-003571-upogtny6 104 36 tested test VBN cord-003571-upogtny6 104 37 among among IN cord-003571-upogtny6 104 38 descendants descendant NNS cord-003571-upogtny6 104 39 . . . cord-003571-upogtny6 105 1 Many many JJ cord-003571-upogtny6 105 2 other other JJ cord-003571-upogtny6 105 3 library library NN cord-003571-upogtny6 105 4 archives archive NNS cord-003571-upogtny6 105 5 exist exist VBP cord-003571-upogtny6 105 6 , , , cord-003571-upogtny6 105 7 although although IN cord-003571-upogtny6 105 8 paper paper NN cord-003571-upogtny6 105 9 - - HYPH cord-003571-upogtny6 105 10 based base VBN cord-003571-upogtny6 105 11 records record NNS cord-003571-upogtny6 105 12 rapidly rapidly RB cord-003571-upogtny6 105 13 decay decay VBP cord-003571-upogtny6 105 14 and and CC cord-003571-upogtny6 105 15 need need VBP cord-003571-upogtny6 105 16 to to TO cord-003571-upogtny6 105 17 be be VB cord-003571-upogtny6 105 18 digitized digitize VBN cord-003571-upogtny6 105 19 as as RB cord-003571-upogtny6 105 20 quickly quickly RB cord-003571-upogtny6 105 21 as as IN cord-003571-upogtny6 105 22 possible possible JJ cord-003571-upogtny6 105 23 . . . cord-003571-upogtny6 106 1 The the DT cord-003571-upogtny6 106 2 detailed detailed JJ cord-003571-upogtny6 106 3 , , , cord-003571-upogtny6 106 4 sometimes sometimes RB cord-003571-upogtny6 106 5 freeform freeform JJ cord-003571-upogtny6 106 6 , , , cord-003571-upogtny6 106 7 notes note NNS cord-003571-upogtny6 106 8 typically typically RB cord-003571-upogtny6 106 9 kept keep VBN cord-003571-upogtny6 106 10 by by IN cord-003571-upogtny6 106 11 the the DT cord-003571-upogtny6 106 12 scientists scientist NNS cord-003571-upogtny6 106 13 at at IN cord-003571-upogtny6 106 14 the the DT cord-003571-upogtny6 106 15 time time NN cord-003571-upogtny6 106 16 mean mean VBP cord-003571-upogtny6 106 17 that that DT cord-003571-upogtny6 106 18 careful careful JJ cord-003571-upogtny6 106 19 examination examination NN cord-003571-upogtny6 106 20 of of IN cord-003571-upogtny6 106 21 these these DT cord-003571-upogtny6 106 22 archives archive NNS cord-003571-upogtny6 106 23 can can MD cord-003571-upogtny6 106 24 sometimes sometimes RB cord-003571-upogtny6 106 25 yield yield VB cord-003571-upogtny6 106 26 surprising surprising JJ cord-003571-upogtny6 106 27 fruit fruit NN cord-003571-upogtny6 106 28 . . . cord-003571-upogtny6 107 1 One one CD cord-003571-upogtny6 107 2 such such JJ cord-003571-upogtny6 107 3 resource resource NN cord-003571-upogtny6 107 4 is be VBZ cord-003571-upogtny6 107 5 the the DT cord-003571-upogtny6 107 6 work work NN cord-003571-upogtny6 107 7 of of IN cord-003571-upogtny6 107 8 Wade Wade NNP cord-003571-upogtny6 107 9 Hampton Hampton NNP cord-003571-upogtny6 107 10 Frost Frost NNP cord-003571-upogtny6 107 11 , , , cord-003571-upogtny6 107 12 who who WP cord-003571-upogtny6 107 13 was be VBD cord-003571-upogtny6 107 14 the the DT cord-003571-upogtny6 107 15 first first JJ cord-003571-upogtny6 107 16 chair chair NN cord-003571-upogtny6 107 17 of of IN cord-003571-upogtny6 107 18 the the DT cord-003571-upogtny6 107 19 Department Department NNP cord-003571-upogtny6 107 20 of of IN cord-003571-upogtny6 107 21 Epidemiology Epidemiology NNP cord-003571-upogtny6 107 22 at at IN cord-003571-upogtny6 107 23 Johns Johns NNP cord-003571-upogtny6 107 24 Hopkins Hopkins NNP cord-003571-upogtny6 107 25 University University NNP cord-003571-upogtny6 107 26 and and CC cord-003571-upogtny6 107 27 a a DT cord-003571-upogtny6 107 28 critical critical JJ cord-003571-upogtny6 107 29 figure figure NN cord-003571-upogtny6 107 30 in in IN cord-003571-upogtny6 107 31 the the DT cord-003571-upogtny6 107 32 fight fight NN cord-003571-upogtny6 107 33 against against IN cord-003571-upogtny6 107 34 the the DT cord-003571-upogtny6 107 35 1918 1918 CD cord-003571-upogtny6 107 36 pandemic pandemic NN cord-003571-upogtny6 107 37 . . . cord-003571-upogtny6 108 1 Modern modern JJ cord-003571-upogtny6 108 2 reanalysis reanalysis NN cord-003571-upogtny6 108 3 of of IN cord-003571-upogtny6 108 4 Dr. Dr. NNP cord-003571-upogtny6 108 5 Frost Frost NNP cord-003571-upogtny6 108 6 's 's POS cord-003571-upogtny6 108 7 detailed detailed JJ cord-003571-upogtny6 108 8 work work NN cord-003571-upogtny6 108 9 ( ( -LRB- cord-003571-upogtny6 108 10 3 3 CD cord-003571-upogtny6 108 11 ) ) -RRB- cord-003571-upogtny6 108 12 has have VBZ cord-003571-upogtny6 108 13 already already RB cord-003571-upogtny6 108 14 yielded yield VBN cord-003571-upogtny6 108 15 abundant abundant JJ cord-003571-upogtny6 108 16 insights insight NNS cord-003571-upogtny6 108 17 , , , cord-003571-upogtny6 108 18 and and CC cord-003571-upogtny6 108 19 we -PRON- PRP cord-003571-upogtny6 108 20 included include VBD cord-003571-upogtny6 108 21 digital digital JJ cord-003571-upogtny6 108 22 copies copy NNS cord-003571-upogtny6 108 23 of of IN cord-003571-upogtny6 108 24 his -PRON- PRP$ cord-003571-upogtny6 108 25 papers paper NNS cord-003571-upogtny6 108 26 on on IN cord-003571-upogtny6 108 27 the the DT cord-003571-upogtny6 108 28 1918 1918 CD cord-003571-upogtny6 108 29 pandemic pandemic NN cord-003571-upogtny6 108 30 from from IN cord-003571-upogtny6 108 31 the the DT cord-003571-upogtny6 108 32 Chesney Chesney NNP cord-003571-upogtny6 108 33 archive archive NN cord-003571-upogtny6 108 34 in in IN cord-003571-upogtny6 108 35 the the DT cord-003571-upogtny6 108 36 Web web NN cord-003571-upogtny6 108 37 Appendix Appendix NNP cord-003571-upogtny6 108 38 ( ( -LRB- cord-003571-upogtny6 108 39 available available JJ cord-003571-upogtny6 108 40 at at IN cord-003571-upogtny6 108 41 https://academic https://academic NNP cord-003571-upogtny6 108 42 . . . cord-003571-upogtny6 109 1 oup.com/aje oup.com/aje NNP cord-003571-upogtny6 109 2 ) ) -RRB- cord-003571-upogtny6 109 3 . . . cord-003571-upogtny6 110 1 The the DT cord-003571-upogtny6 110 2 1918 1918 CD cord-003571-upogtny6 110 3 pandemic pandemic NN cord-003571-upogtny6 110 4 is be VBZ cord-003571-upogtny6 110 5 remarkable remarkable JJ cord-003571-upogtny6 110 6 for for IN cord-003571-upogtny6 110 7 the the DT cord-003571-upogtny6 110 8 large large JJ cord-003571-upogtny6 110 9 amount amount NN cord-003571-upogtny6 110 10 of of IN cord-003571-upogtny6 110 11 extremely extremely RB cord-003571-upogtny6 110 12 detailed detailed JJ cord-003571-upogtny6 110 13 epidemiologic epidemiologic JJ cord-003571-upogtny6 110 14 data datum NNS cord-003571-upogtny6 110 15 collected collect VBN cord-003571-upogtny6 110 16 by by IN cord-003571-upogtny6 110 17 public public JJ cord-003571-upogtny6 110 18 health health NN cord-003571-upogtny6 110 19 officials official NNS cord-003571-upogtny6 110 20 ( ( -LRB- cord-003571-upogtny6 110 21 2 2 CD cord-003571-upogtny6 110 22 , , , cord-003571-upogtny6 110 23 3 3 CD cord-003571-upogtny6 110 24 ) ) -RRB- cord-003571-upogtny6 110 25 , , , cord-003571-upogtny6 110 26 in in IN cord-003571-upogtny6 110 27 part part NN cord-003571-upogtny6 110 28 because because IN cord-003571-upogtny6 110 29 it -PRON- PRP cord-003571-upogtny6 110 30 was be VBD cord-003571-upogtny6 110 31 an an DT cord-003571-upogtny6 110 32 era era NN cord-003571-upogtny6 110 33 that that WDT cord-003571-upogtny6 110 34 valued value VBD cord-003571-upogtny6 110 35 epidemiology epidemiology NN cord-003571-upogtny6 110 36 , , , cord-003571-upogtny6 110 37 at at IN cord-003571-upogtny6 110 38 a a DT cord-003571-upogtny6 110 39 time time NN cord-003571-upogtny6 110 40 when when WRB cord-003571-upogtny6 110 41 analytical analytical JJ cord-003571-upogtny6 110 42 approaches approach NNS cord-003571-upogtny6 110 43 and and CC cord-003571-upogtny6 110 44 knowledge knowledge NN cord-003571-upogtny6 110 45 of of IN cord-003571-upogtny6 110 46 infectious infectious JJ cord-003571-upogtny6 110 47 agents agent NNS cord-003571-upogtny6 110 48 were be VBD cord-003571-upogtny6 110 49 limited limit VBN cord-003571-upogtny6 110 50 . . . cord-003571-upogtny6 111 1 These these DT cord-003571-upogtny6 111 2 exquisitely exquisitely RB cord-003571-upogtny6 111 3 detailed detailed JJ cord-003571-upogtny6 111 4 records record NNS cord-003571-upogtny6 111 5 have have VBP cord-003571-upogtny6 111 6 been be VBN cord-003571-upogtny6 111 7 particularly particularly RB cord-003571-upogtny6 111 8 useful useful JJ cord-003571-upogtny6 111 9 in in IN cord-003571-upogtny6 111 10 the the DT cord-003571-upogtny6 111 11 attempt attempt NN cord-003571-upogtny6 111 12 to to TO cord-003571-upogtny6 111 13 understand understand VB cord-003571-upogtny6 111 14 the the DT cord-003571-upogtny6 111 15 pandemic pandemic NN cord-003571-upogtny6 111 16 retrospectively retrospectively RB cord-003571-upogtny6 111 17 . . . cord-003571-upogtny6 112 1 As as IN cord-003571-upogtny6 112 2 a a DT cord-003571-upogtny6 112 3 thought thought NN cord-003571-upogtny6 112 4 experiment experiment NN cord-003571-upogtny6 112 5 , , , cord-003571-upogtny6 112 6 we -PRON- PRP cord-003571-upogtny6 112 7 can can MD cord-003571-upogtny6 112 8 imagine imagine VB cord-003571-upogtny6 112 9 ourselves -PRON- PRP cord-003571-upogtny6 112 10 in in IN cord-003571-upogtny6 112 11 2118 2118 CD cord-003571-upogtny6 112 12 : : : cord-003571-upogtny6 112 13 We -PRON- PRP cord-003571-upogtny6 112 14 may may MD cord-003571-upogtny6 112 15 ask ask VB cord-003571-upogtny6 112 16 how how WRB cord-003571-upogtny6 112 17 scientists scientist NNS cord-003571-upogtny6 112 18 would would MD cord-003571-upogtny6 112 19 look look VB cord-003571-upogtny6 112 20 back back RB cord-003571-upogtny6 112 21 at at IN cord-003571-upogtny6 112 22 the the DT cord-003571-upogtny6 112 23 large large JJ cord-003571-upogtny6 112 24 amount amount NN cord-003571-upogtny6 112 25 of of IN cord-003571-upogtny6 112 26 data datum NNS cord-003571-upogtny6 112 27 we -PRON- PRP cord-003571-upogtny6 112 28 archive archive VBP cord-003571-upogtny6 112 29 on on IN cord-003571-upogtny6 112 30 a a DT cord-003571-upogtny6 112 31 daily daily JJ cord-003571-upogtny6 112 32 basis basis NN cord-003571-upogtny6 112 33 in in IN cord-003571-upogtny6 112 34 2018 2018 CD cord-003571-upogtny6 112 35 . . . cord-003571-upogtny6 113 1 On on IN cord-003571-upogtny6 113 2 the the DT cord-003571-upogtny6 113 3 one one CD cord-003571-upogtny6 113 4 hand hand NN cord-003571-upogtny6 113 5 , , , cord-003571-upogtny6 113 6 much much RB cord-003571-upogtny6 113 7 if if IN cord-003571-upogtny6 113 8 not not RB cord-003571-upogtny6 113 9 all all DT cord-003571-upogtny6 113 10 of of IN cord-003571-upogtny6 113 11 the the DT cord-003571-upogtny6 113 12 modern modern JJ cord-003571-upogtny6 113 13 data datum NNS cord-003571-upogtny6 113 14 are be VBP cord-003571-upogtny6 113 15 digital digital JJ cord-003571-upogtny6 113 16 , , , cord-003571-upogtny6 113 17 meaning mean VBG cord-003571-upogtny6 113 18 that that IN cord-003571-upogtny6 113 19 they -PRON- PRP cord-003571-upogtny6 113 20 do do VBP cord-003571-upogtny6 113 21 not not RB cord-003571-upogtny6 113 22 run run VB cord-003571-upogtny6 113 23 the the DT cord-003571-upogtny6 113 24 risk risk NN cord-003571-upogtny6 113 25 of of IN cord-003571-upogtny6 113 26 being be VBG cord-003571-upogtny6 113 27 destroyed destroy VBN cord-003571-upogtny6 113 28 by by IN cord-003571-upogtny6 113 29 fire fire NN cord-003571-upogtny6 113 30 or or CC cord-003571-upogtny6 113 31 floods flood NNS cord-003571-upogtny6 113 32 and and CC cord-003571-upogtny6 113 33 they -PRON- PRP cord-003571-upogtny6 113 34 can can MD cord-003571-upogtny6 113 35 be be VB cord-003571-upogtny6 113 36 more more RBR cord-003571-upogtny6 113 37 accessible accessible JJ cord-003571-upogtny6 113 38 to to IN cord-003571-upogtny6 113 39 a a DT cord-003571-upogtny6 113 40 wide wide JJ cord-003571-upogtny6 113 41 audience audience NN cord-003571-upogtny6 113 42 , , , cord-003571-upogtny6 113 43 spurred spur VBN cord-003571-upogtny6 113 44 by by IN cord-003571-upogtny6 113 45 the the DT cord-003571-upogtny6 113 46 open open JJ cord-003571-upogtny6 113 47 access access NN cord-003571-upogtny6 113 48 movement movement NN cord-003571-upogtny6 113 49 . . . cord-003571-upogtny6 114 1 However however RB cord-003571-upogtny6 114 2 , , , cord-003571-upogtny6 114 3 digital digital JJ cord-003571-upogtny6 114 4 data datum NNS cord-003571-upogtny6 114 5 can can MD cord-003571-upogtny6 114 6 also also RB cord-003571-upogtny6 114 7 be be VB cord-003571-upogtny6 114 8 corrupted corrupt VBN cord-003571-upogtny6 114 9 ( ( -LRB- cord-003571-upogtny6 114 10 intentionally intentionally RB cord-003571-upogtny6 114 11 or or CC cord-003571-upogtny6 114 12 unintentionally unintentionally RB cord-003571-upogtny6 114 13 ) ) -RRB- cord-003571-upogtny6 114 14 and and CC cord-003571-upogtny6 114 15 disappear disappear VBP cord-003571-upogtny6 114 16 . . . cord-003571-upogtny6 115 1 Much much RB cord-003571-upogtny6 115 2 from from IN cord-003571-upogtny6 115 3 the the DT cord-003571-upogtny6 115 4 floppy floppy JJ cord-003571-upogtny6 115 5 - - HYPH cord-003571-upogtny6 115 6 disk disk NN cord-003571-upogtny6 115 7 era era NN cord-003571-upogtny6 115 8 has have VBZ cord-003571-upogtny6 115 9 already already RB cord-003571-upogtny6 115 10 been be VBN cord-003571-upogtny6 115 11 permanently permanently RB cord-003571-upogtny6 115 12 lost lose VBN cord-003571-upogtny6 115 13 , , , cord-003571-upogtny6 115 14 and and CC cord-003571-upogtny6 115 15 it -PRON- PRP cord-003571-upogtny6 115 16 is be VBZ cord-003571-upogtny6 115 17 unclear unclear JJ cord-003571-upogtny6 115 18 if if IN cord-003571-upogtny6 115 19 modern modern JJ cord-003571-upogtny6 115 20 cloud cloud NN cord-003571-upogtny6 115 21 - - HYPH cord-003571-upogtny6 115 22 based base VBN cord-003571-upogtny6 115 23 archives archive NNS cord-003571-upogtny6 115 24 would would MD cord-003571-upogtny6 115 25 survive survive VB cord-003571-upogtny6 115 26 a a DT cord-003571-upogtny6 115 27 major major JJ cord-003571-upogtny6 115 28 disruption disruption NN cord-003571-upogtny6 115 29 ( ( -LRB- cord-003571-upogtny6 115 30 whether whether IN cord-003571-upogtny6 115 31 technological technological JJ cord-003571-upogtny6 115 32 or or CC cord-003571-upogtny6 115 33 civil civil JJ cord-003571-upogtny6 115 34 ) ) -RRB- cord-003571-upogtny6 115 35 . . . cord-003571-upogtny6 116 1 Further further RB cord-003571-upogtny6 116 2 , , , cord-003571-upogtny6 116 3 even even RB cord-003571-upogtny6 116 4 today today NN cord-003571-upogtny6 116 5 , , , cord-003571-upogtny6 116 6 there there EX cord-003571-upogtny6 116 7 is be VBZ cord-003571-upogtny6 116 8 a a DT cord-003571-upogtny6 116 9 systematic systematic JJ cord-003571-upogtny6 116 10 dearth dearth NN cord-003571-upogtny6 116 11 of of IN cord-003571-upogtny6 116 12 epidemiologic epidemiologic JJ cord-003571-upogtny6 116 13 and and CC cord-003571-upogtny6 116 14 molecular molecular JJ cord-003571-upogtny6 116 15 data datum NNS cord-003571-upogtny6 116 16 from from IN cord-003571-upogtny6 116 17 low low JJ cord-003571-upogtny6 116 18 - - HYPH cord-003571-upogtny6 116 19 and and CC cord-003571-upogtny6 116 20 middle middle JJ cord-003571-upogtny6 116 21 - - HYPH cord-003571-upogtny6 116 22 income income NN cord-003571-upogtny6 116 23 settings setting NNS cord-003571-upogtny6 116 24 ( ( -LRB- cord-003571-upogtny6 116 25 including include VBG cord-003571-upogtny6 116 26 data datum NNS cord-003571-upogtny6 116 27 on on IN cord-003571-upogtny6 116 28 the the DT cord-003571-upogtny6 116 29 2009 2009 CD cord-003571-upogtny6 116 30 pandemic pandemic NN cord-003571-upogtny6 116 31 ( ( -LRB- cord-003571-upogtny6 116 32 24 24 CD cord-003571-upogtny6 116 33 ) ) -RRB- cord-003571-upogtny6 116 34 ) ) -RRB- cord-003571-upogtny6 116 35 . . . cord-003571-upogtny6 117 1 We -PRON- PRP cord-003571-upogtny6 117 2 are be VBP cord-003571-upogtny6 117 3 just just RB cord-003571-upogtny6 117 4 beginning begin VBG cord-003571-upogtny6 117 5 to to TO cord-003571-upogtny6 117 6 scratch scratch VB cord-003571-upogtny6 117 7 the the DT cord-003571-upogtny6 117 8 surface surface NN cord-003571-upogtny6 117 9 of of IN cord-003571-upogtny6 117 10 the the DT cord-003571-upogtny6 117 11 intricate intricate JJ cord-003571-upogtny6 117 12 relationship relationship NN cord-003571-upogtny6 117 13 between between IN cord-003571-upogtny6 117 14 the the DT cord-003571-upogtny6 117 15 influenza influenza NN cord-003571-upogtny6 117 16 virus virus NN cord-003571-upogtny6 117 17 and and CC cord-003571-upogtny6 117 18 the the DT cord-003571-upogtny6 117 19 complex complex JJ cord-003571-upogtny6 117 20 immune immune JJ cord-003571-upogtny6 117 21 history history NN cord-003571-upogtny6 117 22 of of IN cord-003571-upogtny6 117 23 a a DT cord-003571-upogtny6 117 24 host host NN cord-003571-upogtny6 117 25 who who WP cord-003571-upogtny6 117 26 has have VBZ cord-003571-upogtny6 117 27 had have VBN cord-003571-upogtny6 117 28 repeated repeat VBN cord-003571-upogtny6 117 29 influenza influenza NN cord-003571-upogtny6 117 30 exposures exposure NNS cord-003571-upogtny6 117 31 ( ( -LRB- cord-003571-upogtny6 117 32 9 9 CD cord-003571-upogtny6 117 33 , , , cord-003571-upogtny6 117 34 ( ( -LRB- cord-003571-upogtny6 117 35 18 18 CD cord-003571-upogtny6 117 36 ) ) -RRB- cord-003571-upogtny6 117 37 ( ( -LRB- cord-003571-upogtny6 117 38 19 19 CD cord-003571-upogtny6 117 39 ) ) -RRB- cord-003571-upogtny6 117 40 ( ( -LRB- cord-003571-upogtny6 117 41 20 20 CD cord-003571-upogtny6 117 42 ) ) -RRB- cord-003571-upogtny6 117 43 28 28 CD cord-003571-upogtny6 117 44 ) ) -RRB- cord-003571-upogtny6 117 45 . . . cord-003571-upogtny6 118 1 It -PRON- PRP cord-003571-upogtny6 118 2 is be VBZ cord-003571-upogtny6 118 3 unclear unclear JJ cord-003571-upogtny6 118 4 whether whether IN cord-003571-upogtny6 118 5 we -PRON- PRP cord-003571-upogtny6 118 6 will will MD cord-003571-upogtny6 118 7 be be VB cord-003571-upogtny6 118 8 able able JJ cord-003571-upogtny6 118 9 to to TO cord-003571-upogtny6 118 10 fully fully RB cord-003571-upogtny6 118 11 understand understand VB cord-003571-upogtny6 118 12 these these DT cord-003571-upogtny6 118 13 interactions interaction NNS cord-003571-upogtny6 118 14 in in IN cord-003571-upogtny6 118 15 the the DT cord-003571-upogtny6 118 16 foreseeable foreseeable JJ cord-003571-upogtny6 118 17 future future NN cord-003571-upogtny6 118 18 ; ; : cord-003571-upogtny6 118 19 in in IN cord-003571-upogtny6 118 20 the the DT cord-003571-upogtny6 118 21 meantime meantime NN cord-003571-upogtny6 118 22 , , , cord-003571-upogtny6 118 23 population population NN cord-003571-upogtny6 118 24 birth birth NN cord-003571-upogtny6 118 25 cohorts cohort NNS cord-003571-upogtny6 118 26 carrying carry VBG cord-003571-upogtny6 118 27 important important JJ cord-003571-upogtny6 118 28 influenza influenza NN cord-003571-upogtny6 118 29 immune immune JJ cord-003571-upogtny6 118 30 histories history NNS cord-003571-upogtny6 118 31 disappear disappear VBP cord-003571-upogtny6 118 32 . . . cord-003571-upogtny6 119 1 We -PRON- PRP cord-003571-upogtny6 119 2 echo echo VBP cord-003571-upogtny6 119 3 earlier early RBR cord-003571-upogtny6 119 4 calls call NNS cord-003571-upogtny6 119 5 for for IN cord-003571-upogtny6 119 6 a a DT cord-003571-upogtny6 119 7 time time NN cord-003571-upogtny6 119 8 - - HYPH cord-003571-upogtny6 119 9 stamped stamp VBN cord-003571-upogtny6 119 10 global global JJ cord-003571-upogtny6 119 11 repository repository NN cord-003571-upogtny6 119 12 of of IN cord-003571-upogtny6 119 13 human human JJ cord-003571-upogtny6 119 14 sera sera NNP cord-003571-upogtny6 119 15 and and CC cord-003571-upogtny6 119 16 pathogen pathogen NN cord-003571-upogtny6 119 17 specimens specimen NNS cord-003571-upogtny6 119 18 , , , cord-003571-upogtny6 119 19 ideally ideally RB cord-003571-upogtny6 119 20 together together RB cord-003571-upogtny6 119 21 with with IN cord-003571-upogtny6 119 22 epidemiologic epidemiologic JJ cord-003571-upogtny6 119 23 information information NN cord-003571-upogtny6 119 24 ( ( -LRB- cord-003571-upogtny6 119 25 biobanks biobank NNS cord-003571-upogtny6 119 26 ) ) -RRB- cord-003571-upogtny6 119 27 for for IN cord-003571-upogtny6 119 28 current current JJ cord-003571-upogtny6 119 29 and and CC cord-003571-upogtny6 119 30 future future JJ cord-003571-upogtny6 119 31 use use NN cord-003571-upogtny6 119 32 ( ( -LRB- cord-003571-upogtny6 119 33 29 29 CD cord-003571-upogtny6 119 34 ) ) -RRB- cord-003571-upogtny6 119 35 . . . cord-003571-upogtny6 120 1 We -PRON- PRP cord-003571-upogtny6 120 2 also also RB cord-003571-upogtny6 120 3 applaud applaud VBP cord-003571-upogtny6 120 4 the the DT cord-003571-upogtny6 120 5 push push NN cord-003571-upogtny6 120 6 by by IN cord-003571-upogtny6 120 7 the the DT cord-003571-upogtny6 120 8 US US NNP cord-003571-upogtny6 120 9 National National NNP cord-003571-upogtny6 120 10 Institute Institute NNP cord-003571-upogtny6 120 11 of of IN cord-003571-upogtny6 120 12 Allergy Allergy NNP cord-003571-upogtny6 120 13 and and CC cord-003571-upogtny6 120 14 Infectious Infectious NNP cord-003571-upogtny6 120 15 Diseases Diseases NNPS cord-003571-upogtny6 120 16 to to TO cord-003571-upogtny6 120 17 fund fund VB cord-003571-upogtny6 120 18 international international JJ cord-003571-upogtny6 120 19 influenza influenza NN cord-003571-upogtny6 120 20 birth birth NN cord-003571-upogtny6 120 21 cohort cohort NN cord-003571-upogtny6 120 22 studies study NNS cord-003571-upogtny6 120 23 and and CC cord-003571-upogtny6 120 24 help help VB cord-003571-upogtny6 120 25 untangle untangle VB cord-003571-upogtny6 120 26 the the DT cord-003571-upogtny6 120 27 complex complex JJ cord-003571-upogtny6 120 28 mechanisms mechanism NNS cord-003571-upogtny6 120 29 of of IN cord-003571-upogtny6 120 30 influenza influenza NN cord-003571-upogtny6 120 31 immunity immunity NN cord-003571-upogtny6 120 32 ( ( -LRB- cord-003571-upogtny6 120 33 30 30 CD cord-003571-upogtny6 120 34 ) ) -RRB- cord-003571-upogtny6 120 35 . . . cord-003571-upogtny6 121 1 If if IN cord-003571-upogtny6 121 2 again again RB cord-003571-upogtny6 121 3 confronted confront VBN cord-003571-upogtny6 121 4 with with IN cord-003571-upogtny6 121 5 a a DT cord-003571-upogtny6 121 6 deadly deadly JJ cord-003571-upogtny6 121 7 flu flu NN cord-003571-upogtny6 121 8 pandemic pandemic NN cord-003571-upogtny6 121 9 , , , cord-003571-upogtny6 121 10 we -PRON- PRP cord-003571-upogtny6 121 11 would would MD cord-003571-upogtny6 121 12 be be VB cord-003571-upogtny6 121 13 in in IN cord-003571-upogtny6 121 14 a a DT cord-003571-upogtny6 121 15 better well JJR cord-003571-upogtny6 121 16 place place NN cord-003571-upogtny6 121 17 than than IN cord-003571-upogtny6 121 18 we -PRON- PRP cord-003571-upogtny6 121 19 were be VBD cord-003571-upogtny6 121 20 in in IN cord-003571-upogtny6 121 21 1918 1918 CD cord-003571-upogtny6 121 22 because because IN cord-003571-upogtny6 121 23 of of IN cord-003571-upogtny6 121 24 the the DT cord-003571-upogtny6 121 25 availability availability NN cord-003571-upogtny6 121 26 of of IN cord-003571-upogtny6 121 27 drugs drug NNS cord-003571-upogtny6 121 28 , , , cord-003571-upogtny6 121 29 vaccines vaccine NNS cord-003571-upogtny6 121 30 , , , cord-003571-upogtny6 121 31 and and CC cord-003571-upogtny6 121 32 antibiotics antibiotic NNS cord-003571-upogtny6 121 33 and and CC cord-003571-upogtny6 121 34 the the DT cord-003571-upogtny6 121 35 general general JJ cord-003571-upogtny6 121 36 improvements improvement NNS cord-003571-upogtny6 121 37 in in IN cord-003571-upogtny6 121 38 health health NN cord-003571-upogtny6 121 39 and and CC cord-003571-upogtny6 121 40 nutrition nutrition NN cord-003571-upogtny6 121 41 . . . cord-003571-upogtny6 122 1 There there EX cord-003571-upogtny6 122 2 are be VBP cord-003571-upogtny6 122 3 high high JJ cord-003571-upogtny6 122 4 hopes hope NNS cord-003571-upogtny6 122 5 for for IN cord-003571-upogtny6 122 6 the the DT cord-003571-upogtny6 122 7 development development NN cord-003571-upogtny6 122 8 of of IN cord-003571-upogtny6 122 9 universal universal JJ cord-003571-upogtny6 122 10 vaccines vaccine NNS cord-003571-upogtny6 122 11 , , , cord-003571-upogtny6 122 12 but but CC cord-003571-upogtny6 122 13 we -PRON- PRP cord-003571-upogtny6 122 14 need need VBP cord-003571-upogtny6 122 15 to to TO cord-003571-upogtny6 122 16 keep keep VB cord-003571-upogtny6 122 17 in in IN cord-003571-upogtny6 122 18 mind mind NN cord-003571-upogtny6 122 19 that that IN cord-003571-upogtny6 122 20 influenza influenza NN cord-003571-upogtny6 122 21 is be VBZ cord-003571-upogtny6 122 22 a a DT cord-003571-upogtny6 122 23 rapidly rapidly RB cord-003571-upogtny6 122 24 evolving evolve VBG cord-003571-upogtny6 122 25 virus virus NN cord-003571-upogtny6 122 26 that that WDT cord-003571-upogtny6 122 27 has have VBZ cord-003571-upogtny6 122 28 a a DT cord-003571-upogtny6 122 29 large large JJ cord-003571-upogtny6 122 30 and and CC cord-003571-upogtny6 122 31 diverse diverse JJ cord-003571-upogtny6 122 32 animal animal NN cord-003571-upogtny6 122 33 reservoir reservoir NN cord-003571-upogtny6 122 34 and and CC cord-003571-upogtny6 122 35 presumably presumably RB cord-003571-upogtny6 122 36 many many JJ cord-003571-upogtny6 122 37 tricks trick NNS cord-003571-upogtny6 122 38 in in IN cord-003571-upogtny6 122 39 store store NN cord-003571-upogtny6 122 40 . . . cord-003571-upogtny6 123 1 We -PRON- PRP cord-003571-upogtny6 123 2 can can MD cord-003571-upogtny6 123 3 only only RB cord-003571-upogtny6 123 4 anticipate anticipate VB cord-003571-upogtny6 123 5 another another DT cord-003571-upogtny6 123 6 hundred hundred CD cord-003571-upogtny6 123 7 years year NNS cord-003571-upogtny6 123 8 of of IN cord-003571-upogtny6 123 9 very very RB cord-003571-upogtny6 123 10 active active JJ cord-003571-upogtny6 123 11 , , , cord-003571-upogtny6 123 12 and and CC cord-003571-upogtny6 123 13 always always RB cord-003571-upogtny6 123 14 surprising surprising JJ cord-003571-upogtny6 123 15 , , , cord-003571-upogtny6 123 16 influenza influenza NN cord-003571-upogtny6 123 17 research research NN cord-003571-upogtny6 123 18 . . . cord-003571-upogtny6 124 1 Structure structure NN cord-003571-upogtny6 124 2 of of IN cord-003571-upogtny6 124 3 the the DT cord-003571-upogtny6 124 4 uncleaved uncleaved JJ cord-003571-upogtny6 124 5 human human JJ cord-003571-upogtny6 124 6 H1 H1 NNP cord-003571-upogtny6 124 7 hemagglutinin hemagglutinin NN cord-003571-upogtny6 124 8 from from IN cord-003571-upogtny6 124 9 the the DT cord-003571-upogtny6 124 10 extinct extinct JJ cord-003571-upogtny6 124 11 1918 1918 CD cord-003571-upogtny6 124 12 influenza influenza NN cord-003571-upogtny6 124 13 virus virus NN cord-003571-upogtny6 124 14 Preliminary preliminary JJ cord-003571-upogtny6 124 15 statistics statistic NNS cord-003571-upogtny6 124 16 of of IN cord-003571-upogtny6 124 17 the the DT cord-003571-upogtny6 124 18 influenza influenza NN cord-003571-upogtny6 124 19 epidemic epidemic NN cord-003571-upogtny6 124 20 Influenza Influenza NNP cord-003571-upogtny6 124 21 transmission transmission NN cord-003571-upogtny6 124 22 in in IN cord-003571-upogtny6 124 23 households household NNS cord-003571-upogtny6 124 24 during during IN cord-003571-upogtny6 124 25 the the DT cord-003571-upogtny6 124 26 1918 1918 CD cord-003571-upogtny6 124 27 pandemic pandemic NN cord-003571-upogtny6 125 1 The the DT cord-003571-upogtny6 125 2 Great Great NNP cord-003571-upogtny6 125 3 Influenza Influenza NNP cord-003571-upogtny6 125 4 : : : cord-003571-upogtny6 125 5 The the DT cord-003571-upogtny6 125 6 Story Story NNP cord-003571-upogtny6 125 7 of of IN cord-003571-upogtny6 125 8 the the DT cord-003571-upogtny6 125 9 Deadliest deadly JJS cord-003571-upogtny6 125 10 Pandemic Pandemic NNP cord-003571-upogtny6 125 11 in in IN cord-003571-upogtny6 125 12 History History NNP cord-003571-upogtny6 125 13 Origins Origins NNPS cord-003571-upogtny6 125 14 of of IN cord-003571-upogtny6 125 15 the the DT cord-003571-upogtny6 125 16 1918 1918 CD cord-003571-upogtny6 125 17 pandemic pandemic NN cord-003571-upogtny6 125 18 : : : cord-003571-upogtny6 125 19 revisiting revisit VBG cord-003571-upogtny6 125 20 the the DT cord-003571-upogtny6 125 21 swine swine NN cord-003571-upogtny6 125 22 " " `` cord-003571-upogtny6 125 23 mixing mix VBG cord-003571-upogtny6 125 24 vessel vessel NN cord-003571-upogtny6 125 25 " " '' cord-003571-upogtny6 125 26 hypothesis hypothesis NN cord-003571-upogtny6 125 27 Loose loose JJ cord-003571-upogtny6 125 28 ends end NNS cord-003571-upogtny6 125 29 in in IN cord-003571-upogtny6 125 30 the the DT cord-003571-upogtny6 125 31 epidemiology epidemiology NN cord-003571-upogtny6 125 32 of of IN cord-003571-upogtny6 125 33 the the DT cord-003571-upogtny6 125 34 1918 1918 CD cord-003571-upogtny6 125 35 pandemic pandemic NN cord-003571-upogtny6 125 36 : : : cord-003571-upogtny6 125 37 explaining explain VBG cord-003571-upogtny6 125 38 the the DT cord-003571-upogtny6 125 39 extreme extreme JJ cord-003571-upogtny6 125 40 mortality mortality NN cord-003571-upogtny6 125 41 risk risk NN cord-003571-upogtny6 125 42 in in IN cord-003571-upogtny6 125 43 young young JJ cord-003571-upogtny6 125 44 adults adult NNS cord-003571-upogtny6 125 45 Age age NN cord-003571-upogtny6 125 46 - - HYPH cord-003571-upogtny6 125 47 specific specific JJ cord-003571-upogtny6 125 48 excess excess JJ cord-003571-upogtny6 125 49 mortality mortality NN cord-003571-upogtny6 125 50 patterns pattern NNS cord-003571-upogtny6 125 51 during during IN cord-003571-upogtny6 125 52 the the DT cord-003571-upogtny6 125 53 1918 1918 CD cord-003571-upogtny6 125 54 - - SYM cord-003571-upogtny6 125 55 1920 1920 CD cord-003571-upogtny6 125 56 influenza influenza NN cord-003571-upogtny6 125 57 pandemic pandemic NN cord-003571-upogtny6 125 58 in in IN cord-003571-upogtny6 125 59 Madrid Madrid NNP cord-003571-upogtny6 125 60 , , , cord-003571-upogtny6 125 61 Spain Spain NNP cord-003571-upogtny6 125 62 Influenza Influenza NNP cord-003571-upogtny6 125 63 in in IN cord-003571-upogtny6 125 64 New New NNP cord-003571-upogtny6 125 65 Zealand Zealand NNP cord-003571-upogtny6 125 66 before before IN cord-003571-upogtny6 125 67 1918 1918 CD cord-003571-upogtny6 125 68 : : : cord-003571-upogtny6 125 69 a a DT cord-003571-upogtny6 125 70 preliminary preliminary JJ cord-003571-upogtny6 125 71 report report NN cord-003571-upogtny6 125 72 Investigating investigate VBG cord-003571-upogtny6 125 73 the the DT cord-003571-upogtny6 125 74 legacy legacy NN cord-003571-upogtny6 125 75 of of IN cord-003571-upogtny6 125 76 1918 1918 CD cord-003571-upogtny6 125 77 pandemic pandemic NN cord-003571-upogtny6 125 78 on on IN cord-003571-upogtny6 125 79 age age NN cord-003571-upogtny6 125 80 - - HYPH cord-003571-upogtny6 125 81 related relate VBN cord-003571-upogtny6 125 82 seroepidemiology seroepidemiology NN cord-003571-upogtny6 125 83 and and CC cord-003571-upogtny6 125 84 immune immune JJ cord-003571-upogtny6 125 85 responses response NNS cord-003571-upogtny6 125 86 to to IN cord-003571-upogtny6 125 87 subsequent subsequent JJ cord-003571-upogtny6 125 88 influenza influenza NN cord-003571-upogtny6 125 89 A(H1N1 A(H1N1 NNP cord-003571-upogtny6 125 90 ) ) -RRB- cord-003571-upogtny6 125 91 viruses viruse VBZ cord-003571-upogtny6 125 92 through through IN cord-003571-upogtny6 125 93 a a DT cord-003571-upogtny6 125 94 structural structural JJ cord-003571-upogtny6 125 95 equation equation NN cord-003571-upogtny6 125 96 model model NN cord-003571-upogtny6 126 1 The the DT cord-003571-upogtny6 126 2 1918 1918 CD cord-003571-upogtny6 126 3 - - SYM cord-003571-upogtny6 126 4 1919 1919 CD cord-003571-upogtny6 126 5 influenza influenza NN cord-003571-upogtny6 126 6 pandemic pandemic NN cord-003571-upogtny6 126 7 in in IN cord-003571-upogtny6 126 8 Portugal Portugal NNP cord-003571-upogtny6 126 9 : : : cord-003571-upogtny6 126 10 a a DT cord-003571-upogtny6 126 11 regional regional JJ cord-003571-upogtny6 126 12 analysis analysis NN cord-003571-upogtny6 126 13 of of IN cord-003571-upogtny6 126 14 death death NN cord-003571-upogtny6 126 15 impact impact NN cord-003571-upogtny6 127 1 Spatiotemporal spatiotemporal JJ cord-003571-upogtny6 127 2 patterns pattern NNS cord-003571-upogtny6 127 3 and and CC cord-003571-upogtny6 127 4 diffusion diffusion NN cord-003571-upogtny6 127 5 of of IN cord-003571-upogtny6 127 6 the the DT cord-003571-upogtny6 127 7 1918 1918 CD cord-003571-upogtny6 127 8 influenza influenza NN cord-003571-upogtny6 127 9 pandemic pandemic NN cord-003571-upogtny6 127 10 in in IN cord-003571-upogtny6 127 11 British british JJ cord-003571-upogtny6 127 12 India India NNP cord-003571-upogtny6 127 13 Reassessing reassess VBG cord-003571-upogtny6 127 14 the the DT cord-003571-upogtny6 127 15 global global JJ cord-003571-upogtny6 127 16 mortality mortality NN cord-003571-upogtny6 127 17 burden burden NN cord-003571-upogtny6 127 18 of of IN cord-003571-upogtny6 127 19 the the DT cord-003571-upogtny6 127 20 1918 1918 CD cord-003571-upogtny6 127 21 influenza influenza NN cord-003571-upogtny6 127 22 pandemic pandemic JJ cord-003571-upogtny6 127 23 Social Social NNP cord-003571-upogtny6 127 24 class class NN cord-003571-upogtny6 127 25 and and CC cord-003571-upogtny6 127 26 excess excess JJ cord-003571-upogtny6 127 27 mortality mortality NN cord-003571-upogtny6 127 28 in in IN cord-003571-upogtny6 127 29 Sweden Sweden NNP cord-003571-upogtny6 127 30 during during IN cord-003571-upogtny6 127 31 the the DT cord-003571-upogtny6 127 32 1918 1918 CD cord-003571-upogtny6 127 33 influenza influenza NN cord-003571-upogtny6 127 34 pandemic pandemic JJ cord-003571-upogtny6 127 35 Natality Natality NNP cord-003571-upogtny6 127 36 decline decline NN cord-003571-upogtny6 127 37 and and CC cord-003571-upogtny6 127 38 spatial spatial JJ cord-003571-upogtny6 127 39 variation variation NN cord-003571-upogtny6 127 40 in in IN cord-003571-upogtny6 127 41 excess excess JJ cord-003571-upogtny6 127 42 death death NN cord-003571-upogtny6 127 43 rates rate NNS cord-003571-upogtny6 127 44 during during IN cord-003571-upogtny6 127 45 the the DT cord-003571-upogtny6 127 46 1918 1918 CD cord-003571-upogtny6 127 47 - - SYM cord-003571-upogtny6 127 48 1920 1920 CD cord-003571-upogtny6 127 49 influenza influenza NN cord-003571-upogtny6 127 50 pandemic pandemic NN cord-003571-upogtny6 127 51 in in IN cord-003571-upogtny6 127 52 Arizona Arizona NNP cord-003571-upogtny6 127 53 , , , cord-003571-upogtny6 127 54 United United NNP cord-003571-upogtny6 127 55 States States NNP cord-003571-upogtny6 127 56 Short Short NNP cord-003571-upogtny6 127 57 - - HYPH cord-003571-upogtny6 127 58 term term NN cord-003571-upogtny6 127 59 birth birth NN cord-003571-upogtny6 127 60 sequelae sequela NNS cord-003571-upogtny6 127 61 of of IN cord-003571-upogtny6 127 62 the the DT cord-003571-upogtny6 127 63 1918 1918 CD cord-003571-upogtny6 127 64 - - SYM cord-003571-upogtny6 127 65 1920 1920 CD cord-003571-upogtny6 127 66 influenza influenza NN cord-003571-upogtny6 127 67 pandemic pandemic NN cord-003571-upogtny6 127 68 in in IN cord-003571-upogtny6 127 69 the the DT cord-003571-upogtny6 127 70 United United NNP cord-003571-upogtny6 127 71 States States NNP cord-003571-upogtny6 127 72 : : : cord-003571-upogtny6 128 1 state state NN cord-003571-upogtny6 128 2 - - HYPH cord-003571-upogtny6 128 3 level level NN cord-003571-upogtny6 128 4 analysis analysis NN cord-003571-upogtny6 128 5 Readiness readiness NN cord-003571-upogtny6 128 6 for for IN cord-003571-upogtny6 128 7 responding respond VBG cord-003571-upogtny6 128 8 to to IN cord-003571-upogtny6 128 9 a a DT cord-003571-upogtny6 128 10 severe severe JJ cord-003571-upogtny6 128 11 pandemic pandemic NN cord-003571-upogtny6 128 12 100 100 CD cord-003571-upogtny6 128 13 years year NNS cord-003571-upogtny6 128 14 after after IN cord-003571-upogtny6 128 15 1918 1918 CD cord-003571-upogtny6 128 16 Universal Universal NNP cord-003571-upogtny6 128 17 influenza influenza NN cord-003571-upogtny6 128 18 vaccines vaccine NNS cord-003571-upogtny6 128 19 : : : cord-003571-upogtny6 128 20 progress progress VB cord-003571-upogtny6 128 21 in in IN cord-003571-upogtny6 128 22 achieving achieve VBG cord-003571-upogtny6 128 23 broad broad JJ cord-003571-upogtny6 128 24 cross cross NN cord-003571-upogtny6 128 25 - - NN cord-003571-upogtny6 128 26 protection protection NN cord-003571-upogtny6 128 27 in in IN cord-003571-upogtny6 128 28 vivo vivo NNP cord-003571-upogtny6 128 29 Potent potent JJ cord-003571-upogtny6 128 30 protection protection NN cord-003571-upogtny6 128 31 against against IN cord-003571-upogtny6 128 32 H5N1 H5N1 NNP cord-003571-upogtny6 128 33 and and CC cord-003571-upogtny6 128 34 H7N9 H7N9 NNP cord-003571-upogtny6 128 35 influenza influenza NN cord-003571-upogtny6 128 36 via via IN cord-003571-upogtny6 128 37 childhood childhood NN cord-003571-upogtny6 128 38 hemagglutinin hemagglutinin NN cord-003571-upogtny6 128 39 imprinting imprinting NN cord-003571-upogtny6 128 40 Re Re VBG cord-003571-upogtny6 128 41 - - VBG cord-003571-upogtny6 128 42 examining examine VBG cord-003571-upogtny6 128 43 the the DT cord-003571-upogtny6 128 44 evidence evidence NN cord-003571-upogtny6 128 45 regarding regard VBG cord-003571-upogtny6 128 46 circulation circulation NN cord-003571-upogtny6 128 47 of of IN cord-003571-upogtny6 128 48 a a DT cord-003571-upogtny6 128 49 human human JJ cord-003571-upogtny6 128 50 H1 H1 NNP cord-003571-upogtny6 128 51 influenza influenza NN cord-003571-upogtny6 128 52 virus virus NN cord-003571-upogtny6 128 53 immediately immediately RB cord-003571-upogtny6 128 54 prior prior RB cord-003571-upogtny6 128 55 to to IN cord-003571-upogtny6 128 56 the the DT cord-003571-upogtny6 128 57 1918 1918 CD cord-003571-upogtny6 128 58 Spanish spanish JJ cord-003571-upogtny6 128 59 flu flu NN cord-003571-upogtny6 128 60 Age Age NNP cord-003571-upogtny6 128 61 - - : cord-003571-upogtny6 128 62 and and CC cord-003571-upogtny6 128 63 sex sex NN cord-003571-upogtny6 128 64 - - HYPH cord-003571-upogtny6 128 65 specific specific JJ cord-003571-upogtny6 128 66 mortality mortality NN cord-003571-upogtny6 128 67 associated associate VBN cord-003571-upogtny6 128 68 with with IN cord-003571-upogtny6 128 69 the the DT cord-003571-upogtny6 128 70 1918 1918 CD cord-003571-upogtny6 128 71 - - SYM cord-003571-upogtny6 128 72 1919 1919 CD cord-003571-upogtny6 128 73 influenza influenza NN cord-003571-upogtny6 128 74 pandemic pandemic NN cord-003571-upogtny6 128 75 in in IN cord-003571-upogtny6 128 76 Kentucky Kentucky NNP cord-003571-upogtny6 128 77 Epidemiological epidemiological JJ cord-003571-upogtny6 128 78 evidence evidence NN cord-003571-upogtny6 128 79 of of IN cord-003571-upogtny6 128 80 an an DT cord-003571-upogtny6 128 81 early early JJ cord-003571-upogtny6 128 82 wave wave NN cord-003571-upogtny6 128 83 of of IN cord-003571-upogtny6 128 84 the the DT cord-003571-upogtny6 128 85 1918 1918 CD cord-003571-upogtny6 128 86 influenza influenza NN cord-003571-upogtny6 128 87 pandemic pandemic NN cord-003571-upogtny6 128 88 in in IN cord-003571-upogtny6 128 89 New New NNP cord-003571-upogtny6 128 90 York York NNP cord-003571-upogtny6 128 91 City City NNP cord-003571-upogtny6 128 92 Influenza Influenza NNP cord-003571-upogtny6 128 93 epidemics epidemic NNS cord-003571-upogtny6 128 94 in in IN cord-003571-upogtny6 128 95 Iceland Iceland NNP cord-003571-upogtny6 128 96 over over IN cord-003571-upogtny6 128 97 9 9 CD cord-003571-upogtny6 128 98 decades decade NNS cord-003571-upogtny6 128 99 : : : cord-003571-upogtny6 128 100 changes change NNS cord-003571-upogtny6 128 101 in in IN cord-003571-upogtny6 128 102 timing timing NN cord-003571-upogtny6 128 103 and and CC cord-003571-upogtny6 128 104 synchrony synchrony NN cord-003571-upogtny6 128 105 with with IN cord-003571-upogtny6 128 106 the the DT cord-003571-upogtny6 128 107 United United NNP cord-003571-upogtny6 128 108 States States NNP cord-003571-upogtny6 128 109 and and CC cord-003571-upogtny6 128 110 Europe Europe NNP cord-003571-upogtny6 128 111 Estimation Estimation NNP cord-003571-upogtny6 128 112 of of IN cord-003571-upogtny6 128 113 potential potential JJ cord-003571-upogtny6 128 114 global global JJ cord-003571-upogtny6 128 115 pandemic pandemic NN cord-003571-upogtny6 128 116 influenza influenza NN cord-003571-upogtny6 128 117 mortality mortality NN cord-003571-upogtny6 128 118 on on IN cord-003571-upogtny6 128 119 the the DT cord-003571-upogtny6 128 120 basis basis NN cord-003571-upogtny6 128 121 of of IN cord-003571-upogtny6 128 122 vital vital JJ cord-003571-upogtny6 128 123 registry registry NN cord-003571-upogtny6 128 124 data datum NNS cord-003571-upogtny6 128 125 from from IN cord-003571-upogtny6 128 126 the the DT cord-003571-upogtny6 128 127 1918 1918 CD cord-003571-upogtny6 128 128 - - SYM cord-003571-upogtny6 128 129 20 20 CD cord-003571-upogtny6 128 130 pandemic pandemic NN cord-003571-upogtny6 128 131 : : : cord-003571-upogtny6 128 132 a a DT cord-003571-upogtny6 128 133 quantitative quantitative JJ cord-003571-upogtny6 128 134 analysis analysis NN cord-003571-upogtny6 128 135 Global global JJ cord-003571-upogtny6 128 136 mortality mortality NN cord-003571-upogtny6 128 137 estimates estimate NNS cord-003571-upogtny6 128 138 for for IN cord-003571-upogtny6 128 139 the the DT cord-003571-upogtny6 128 140 2009 2009 CD cord-003571-upogtny6 128 141 influenza influenza NN cord-003571-upogtny6 128 142 pandemic pandemic NN cord-003571-upogtny6 128 143 from from IN cord-003571-upogtny6 128 144 the the DT cord-003571-upogtny6 128 145 GLaMOR GLaMOR NNP cord-003571-upogtny6 128 146 project project NN cord-003571-upogtny6 128 147 : : : cord-003571-upogtny6 129 1 a a DT cord-003571-upogtny6 129 2 modeling modeling NN cord-003571-upogtny6 129 3 study study NN cord-003571-upogtny6 129 4 Natality Natality NNP cord-003571-upogtny6 129 5 decline decline NN cord-003571-upogtny6 129 6 and and CC cord-003571-upogtny6 129 7 miscarriages miscarriage NNS cord-003571-upogtny6 129 8 associated associate VBN cord-003571-upogtny6 129 9 with with IN cord-003571-upogtny6 129 10 the the DT cord-003571-upogtny6 129 11 1918 1918 CD cord-003571-upogtny6 129 12 influenza influenza NN cord-003571-upogtny6 129 13 pandemic pandemic NN cord-003571-upogtny6 129 14 : : : cord-003571-upogtny6 130 1 the the DT cord-003571-upogtny6 130 2 Scandinavian scandinavian JJ cord-003571-upogtny6 130 3 and and CC cord-003571-upogtny6 130 4 United United NNP cord-003571-upogtny6 130 5 States States NNP cord-003571-upogtny6 130 6 experiences experience VBZ cord-003571-upogtny6 130 7 Transmissibility Transmissibility NNP cord-003571-upogtny6 130 8 and and CC cord-003571-upogtny6 130 9 geographic geographic JJ cord-003571-upogtny6 130 10 spread spread NN cord-003571-upogtny6 130 11 of of IN cord-003571-upogtny6 130 12 the the DT cord-003571-upogtny6 130 13 1889 1889 CD cord-003571-upogtny6 130 14 influenza influenza NN cord-003571-upogtny6 130 15 pandemic pandemic NN cord-003571-upogtny6 130 16 Age age NN cord-003571-upogtny6 130 17 - - HYPH cord-003571-upogtny6 130 18 specific specific JJ cord-003571-upogtny6 130 19 excess excess JJ cord-003571-upogtny6 130 20 mortality mortality NN cord-003571-upogtny6 130 21 patterns pattern NNS cord-003571-upogtny6 130 22 and and CC cord-003571-upogtny6 130 23 transmissibility transmissibility NN cord-003571-upogtny6 130 24 during during IN cord-003571-upogtny6 130 25 the the DT cord-003571-upogtny6 130 26 1889 1889 CD cord-003571-upogtny6 130 27 - - SYM cord-003571-upogtny6 130 28 1890 1890 CD cord-003571-upogtny6 130 29 influenza influenza NN cord-003571-upogtny6 130 30 pandemic pandemic NN cord-003571-upogtny6 130 31 in in IN cord-003571-upogtny6 130 32 Madrid Madrid NNP cord-003571-upogtny6 131 1 , , , cord-003571-upogtny6 131 2 Spain Spain NNP cord-003571-upogtny6 131 3 Evidence evidence NN cord-003571-upogtny6 131 4 for for IN cord-003571-upogtny6 131 5 antigenic antigenic JJ cord-003571-upogtny6 131 6 seniority seniority NN cord-003571-upogtny6 131 7 in in IN cord-003571-upogtny6 131 8 influenza influenza NN cord-003571-upogtny6 131 9 A a NN cord-003571-upogtny6 131 10 ( ( -LRB- cord-003571-upogtny6 131 11 H3N2 H3N2 NNP cord-003571-upogtny6 131 12 ) ) -RRB- cord-003571-upogtny6 131 13 antibody antibody NN cord-003571-upogtny6 131 14 responses response NNS cord-003571-upogtny6 131 15 in in IN cord-003571-upogtny6 131 16 southern southern JJ cord-003571-upogtny6 131 17 China China NNP cord-003571-upogtny6 131 18 Use Use NNP cord-003571-upogtny6 131 19 of of IN cord-003571-upogtny6 131 20 serological serological JJ cord-003571-upogtny6 131 21 surveys survey NNS cord-003571-upogtny6 131 22 to to TO cord-003571-upogtny6 131 23 generate generate VB cord-003571-upogtny6 131 24 key key JJ cord-003571-upogtny6 131 25 insights insight NNS cord-003571-upogtny6 131 26 into into IN cord-003571-upogtny6 131 27 the the DT cord-003571-upogtny6 131 28 changing change VBG cord-003571-upogtny6 131 29 global global JJ cord-003571-upogtny6 131 30 landscape landscape NN cord-003571-upogtny6 131 31 of of IN cord-003571-upogtny6 131 32 infectious infectious JJ cord-003571-upogtny6 131 33 disease disease NN cord-003571-upogtny6 132 1 The the DT cord-003571-upogtny6 132 2 ghost ghost NN cord-003571-upogtny6 132 3 of of IN cord-003571-upogtny6 132 4 influenza influenza NN cord-003571-upogtny6 132 5 past past NN cord-003571-upogtny6 132 6 and and CC cord-003571-upogtny6 132 7 the the DT cord-003571-upogtny6 132 8 hunt hunt NN cord-003571-upogtny6 132 9 for for IN cord-003571-upogtny6 132 10 a a DT cord-003571-upogtny6 132 11 universal universal JJ cord-003571-upogtny6 132 12 vaccine vaccine NN cord-003571-upogtny6 132 13 This this DT cord-003571-upogtny6 132 14 article article NN cord-003571-upogtny6 132 15 does do VBZ cord-003571-upogtny6 132 16 not not RB cord-003571-upogtny6 132 17 necessarily necessarily RB cord-003571-upogtny6 132 18 represent represent VB cord-003571-upogtny6 132 19 the the DT cord-003571-upogtny6 132 20 views view NNS cord-003571-upogtny6 132 21 of of IN cord-003571-upogtny6 132 22 the the DT cord-003571-upogtny6 132 23 National National NNP cord-003571-upogtny6 132 24 Institutes Institutes NNPS cord-003571-upogtny6 132 25 of of IN cord-003571-upogtny6 132 26 Health Health NNP cord-003571-upogtny6 132 27 or or CC cord-003571-upogtny6 132 28 the the DT cord-003571-upogtny6 132 29 US US NNP cord-003571-upogtny6 132 30 government government NN cord-003571-upogtny6 132 31 . . . cord-003571-upogtny6 133 1 Conflict conflict NN cord-003571-upogtny6 133 2 of of IN cord-003571-upogtny6 133 3 interest interest NN cord-003571-upogtny6 133 4 : : : cord-003571-upogtny6 133 5 none none NN cord-003571-upogtny6 133 6 declared declare VBD cord-003571-upogtny6 133 7 . . .