id	sid	tid	token	lemma	pos
cord-003921-8r8z0otz	1	1	key	key	JJ
cord-003921-8r8z0otz	1	2	:	:	:
cord-003921-8r8z0otz	1	3	cord-003921	cord-003921	NNP
cord-003921-8r8z0otz	1	4	-	-	HYPH
cord-003921-8r8z0otz	1	5	8r8z0otz	8r8z0otz	NNP
cord-003921-8r8z0otz	1	6	authors	author	NNS
cord-003921-8r8z0otz	1	7	:	:	:
cord-003921-8r8z0otz	1	8	Nakamura	Nakamura	NNP
cord-003921-8r8z0otz	1	9	,	,	,
cord-003921-8r8z0otz	1	10	Kojiro	Kojiro	NNP
cord-003921-8r8z0otz	1	11	;	;	:
cord-003921-8r8z0otz	1	12	Kageyama	Kageyama	NNP
cord-003921-8r8z0otz	1	13	,	,	,
cord-003921-8r8z0otz	1	14	Shoichi	Shoichi	NNP
cord-003921-8r8z0otz	1	15	;	;	:
cord-003921-8r8z0otz	1	16	Kupiec	Kupiec	NNP
cord-003921-8r8z0otz	1	17	-	-	HYPH
cord-003921-8r8z0otz	1	18	Weglinski	Weglinski	NNP
cord-003921-8r8z0otz	1	19	,	,	,
cord-003921-8r8z0otz	2	1	Jerzy	Jerzy	NNP
cord-003921-8r8z0otz	2	2	W.	W.	NNP
cord-003921-8r8z0otz	2	3	title	title	NN
cord-003921-8r8z0otz	2	4	:	:	:
cord-003921-8r8z0otz	3	1	The	the	DT
cord-003921-8r8z0otz	3	2	Evolving	evolve	VBG
cord-003921-8r8z0otz	3	3	Role	role	NN
cord-003921-8r8z0otz	3	4	of	of	IN
cord-003921-8r8z0otz	3	5	Neutrophils	Neutrophils	NNP
cord-003921-8r8z0otz	3	6	in	in	IN
cord-003921-8r8z0otz	3	7	Liver	Liver	NNP
cord-003921-8r8z0otz	3	8	Transplant	Transplant	NNP
cord-003921-8r8z0otz	4	1	Ischemia	ischemia	NN
cord-003921-8r8z0otz	4	2	-	-	HYPH
cord-003921-8r8z0otz	4	3	Reperfusion	reperfusion	NN
cord-003921-8r8z0otz	4	4	Injury	injury	NN
cord-003921-8r8z0otz	4	5	date	date	NN
cord-003921-8r8z0otz	5	1	:	:	:
cord-003921-8r8z0otz	5	2	2019	2019	CD
cord-003921-8r8z0otz	5	3	-	-	HYPH
cord-003921-8r8z0otz	5	4	01	01	CD
cord-003921-8r8z0otz	5	5	-	-	HYPH
cord-003921-8r8z0otz	5	6	29	29	CD
cord-003921-8r8z0otz	5	7	journal	journal	NN
cord-003921-8r8z0otz	5	8	:	:	:
cord-003921-8r8z0otz	6	1	Curr	Curr	NNP
cord-003921-8r8z0otz	6	2	Transplant	Transplant	NNP
cord-003921-8r8z0otz	6	3	Rep	Rep	NNP
cord-003921-8r8z0otz	6	4	DOI	DOI	NNP
cord-003921-8r8z0otz	6	5	:	:	:
cord-003921-8r8z0otz	6	6	10.1007	10.1007	CD
cord-003921-8r8z0otz	6	7	/	/	SYM
cord-003921-8r8z0otz	6	8	s40472	s40472	NN
cord-003921-8r8z0otz	6	9	-	-	HYPH
cord-003921-8r8z0otz	6	10	019	019	CD
cord-003921-8r8z0otz	6	11	-	-	HYPH
cord-003921-8r8z0otz	6	12	0230	0230	CD
cord-003921-8r8z0otz	6	13	-	-	SYM
cord-003921-8r8z0otz	6	14	4	4	CD
cord-003921-8r8z0otz	6	15	sha	sha	NNP
cord-003921-8r8z0otz	6	16	:	:	:
cord-003921-8r8z0otz	7	1	4ea8a929038f3eb19f051a4f39457b3a29a56603	4ea8a929038f3eb19f051a4f39457b3a29a56603	LS
cord-003921-8r8z0otz	8	1	doc_id	doc_id	CD
cord-003921-8r8z0otz	9	1	:	:	:
cord-003921-8r8z0otz	9	2	3921	3921	CD
cord-003921-8r8z0otz	9	3	cord_uid	cord_uid	NNS
cord-003921-8r8z0otz	9	4	:	:	:
cord-003921-8r8z0otz	10	1	8r8z0otz	8r8z0otz	CD
cord-003921-8r8z0otz	10	2	PURPOSE	purpose	NN
cord-003921-8r8z0otz	10	3	OF	of	IN
cord-003921-8r8z0otz	10	4	REVIEW	review	NN
cord-003921-8r8z0otz	10	5	:	:	:
cord-003921-8r8z0otz	11	1	Hepatic	hepatic	JJ
cord-003921-8r8z0otz	11	2	ischemia	ischemia	NN
cord-003921-8r8z0otz	11	3	-	-	HYPH
cord-003921-8r8z0otz	11	4	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	11	5	injury	injury	NN
cord-003921-8r8z0otz	11	6	(	(	-LRB-
cord-003921-8r8z0otz	11	7	IRI	IRI	NNP
cord-003921-8r8z0otz	11	8	)	)	-RRB-
cord-003921-8r8z0otz	11	9	,	,	,
cord-003921-8r8z0otz	11	10	an	an	DT
cord-003921-8r8z0otz	11	11	inevitable	inevitable	JJ
cord-003921-8r8z0otz	11	12	event	event	NN
cord-003921-8r8z0otz	11	13	during	during	IN
cord-003921-8r8z0otz	11	14	liver	liver	NN
cord-003921-8r8z0otz	11	15	transplantation	transplantation	NN
cord-003921-8r8z0otz	11	16	,	,	,
cord-003921-8r8z0otz	11	17	represents	represent	VBZ
cord-003921-8r8z0otz	11	18	a	a	DT
cord-003921-8r8z0otz	11	19	major	major	JJ
cord-003921-8r8z0otz	11	20	risk	risk	NN
cord-003921-8r8z0otz	11	21	factor	factor	NN
cord-003921-8r8z0otz	11	22	for	for	IN
cord-003921-8r8z0otz	11	23	the	the	DT
cord-003921-8r8z0otz	11	24	primary	primary	JJ
cord-003921-8r8z0otz	11	25	graft	graft	NN
cord-003921-8r8z0otz	11	26	dysfunction	dysfunction	NN
cord-003921-8r8z0otz	11	27	as	as	RB
cord-003921-8r8z0otz	11	28	well	well	RB
cord-003921-8r8z0otz	11	29	as	as	IN
cord-003921-8r8z0otz	11	30	the	the	DT
cord-003921-8r8z0otz	11	31	development	development	NN
cord-003921-8r8z0otz	11	32	of	of	IN
cord-003921-8r8z0otz	11	33	acute	acute	JJ
cord-003921-8r8z0otz	11	34	and	and	CC
cord-003921-8r8z0otz	11	35	chronic	chronic	JJ
cord-003921-8r8z0otz	11	36	rejection	rejection	NN
cord-003921-8r8z0otz	11	37	.	.	.
cord-003921-8r8z0otz	12	1	Neutrophils	neutrophils	NN
cord-003921-8r8z0otz	12	2	,	,	,
cord-003921-8r8z0otz	12	3	along	along	IN
cord-003921-8r8z0otz	12	4	macrophages	macrophage	NNS
cord-003921-8r8z0otz	12	5	,	,	,
cord-003921-8r8z0otz	12	6	are	be	VBP
cord-003921-8r8z0otz	12	7	pivotal	pivotal	JJ
cord-003921-8r8z0otz	12	8	in	in	IN
cord-003921-8r8z0otz	12	9	the	the	DT
cord-003921-8r8z0otz	12	10	innate	innate	JJ
cord-003921-8r8z0otz	12	11	immune	immune	NN
cord-003921-8r8z0otz	12	12	-	-	HYPH
cord-003921-8r8z0otz	12	13	driven	drive	VBN
cord-003921-8r8z0otz	12	14	liver	liver	NN
cord-003921-8r8z0otz	12	15	IRI	IRI	NNP
cord-003921-8r8z0otz	12	16	,	,	,
cord-003921-8r8z0otz	12	17	whereas	whereas	IN
cord-003921-8r8z0otz	12	18	the	the	DT
cord-003921-8r8z0otz	12	19	effective	effective	JJ
cord-003921-8r8z0otz	12	20	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	12	21	-	-	HYPH
cord-003921-8r8z0otz	12	22	targeting	target	VBG
cord-003921-8r8z0otz	12	23	therapies	therapy	NNS
cord-003921-8r8z0otz	12	24	remain	remain	VBP
cord-003921-8r8z0otz	12	25	to	to	TO
cord-003921-8r8z0otz	12	26	be	be	VB
cord-003921-8r8z0otz	12	27	established	establish	VBN
cord-003921-8r8z0otz	12	28	.	.	.
cord-003921-8r8z0otz	13	1	In	in	IN
cord-003921-8r8z0otz	13	2	this	this	DT
cord-003921-8r8z0otz	13	3	review	review	NN
cord-003921-8r8z0otz	13	4	,	,	,
cord-003921-8r8z0otz	13	5	we	-PRON-	PRP
cord-003921-8r8z0otz	13	6	summarize	summarize	VBP
cord-003921-8r8z0otz	13	7	progress	progress	NN
cord-003921-8r8z0otz	13	8	in	in	IN
cord-003921-8r8z0otz	13	9	our	-PRON-	PRP$
cord-003921-8r8z0otz	13	10	appreciation	appreciation	NN
cord-003921-8r8z0otz	13	11	of	of	IN
cord-003921-8r8z0otz	13	12	the	the	DT
cord-003921-8r8z0otz	13	13	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	13	14	biology	biology	NN
cord-003921-8r8z0otz	13	15	and	and	CC
cord-003921-8r8z0otz	13	16	discuss	discuss	VB
cord-003921-8r8z0otz	13	17	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	13	18	-	-	HYPH
cord-003921-8r8z0otz	13	19	based	base	VBN
cord-003921-8r8z0otz	13	20	therapeutic	therapeutic	JJ
cord-003921-8r8z0otz	13	21	perspectives	perspective	NNS
cord-003921-8r8z0otz	13	22	.	.	.
cord-003921-8r8z0otz	14	1	RECENT	recent	JJ
cord-003921-8r8z0otz	14	2	FINDINGS	finding	NNS
cord-003921-8r8z0otz	14	3	:	:	:
cord-003921-8r8z0otz	15	1	New	new	JJ
cord-003921-8r8z0otz	15	2	technological	technological	JJ
cord-003921-8r8z0otz	15	3	advances	advance	NNS
cord-003921-8r8z0otz	15	4	enable	enable	VBP
cord-003921-8r8z0otz	15	5	to	to	TO
cord-003921-8r8z0otz	15	6	accurately	accurately	RB
cord-003921-8r8z0otz	15	7	track	track	VB
cord-003921-8r8z0otz	15	8	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	15	9	movements	movement	NNS
cord-003921-8r8z0otz	15	10	and	and	CC
cord-003921-8r8z0otz	15	11	help	help	VBP
cord-003921-8r8z0otz	15	12	to	to	TO
cord-003921-8r8z0otz	15	13	understand	understand	VB
cord-003921-8r8z0otz	15	14	molecular	molecular	JJ
cord-003921-8r8z0otz	15	15	mechanisms	mechanism	NNS
cord-003921-8r8z0otz	15	16	in	in	IN
cord-003921-8r8z0otz	15	17	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	15	18	function	function	NN
cord-003921-8r8z0otz	15	19	,	,	,
cord-003921-8r8z0otz	15	20	such	such	JJ
cord-003921-8r8z0otz	15	21	as	as	IN
cord-003921-8r8z0otz	15	22	selective	selective	JJ
cord-003921-8r8z0otz	15	23	recruitment	recruitment	NN
cord-003921-8r8z0otz	15	24	to	to	IN
cord-003921-8r8z0otz	15	25	IR	IR	NNP
cord-003921-8r8z0otz	15	26	-	-	HYPH
cord-003921-8r8z0otz	15	27	stressed	stress	VBN
cord-003921-8r8z0otz	15	28	tissue	tissue	NN
cord-003921-8r8z0otz	15	29	,	,	,
cord-003921-8r8z0otz	15	30	formation	formation	NN
cord-003921-8r8z0otz	15	31	of	of	IN
cord-003921-8r8z0otz	15	32	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	15	33	extracellular	extracellular	JJ
cord-003921-8r8z0otz	15	34	traps	trap	NNS
cord-003921-8r8z0otz	15	35	,	,	,
cord-003921-8r8z0otz	15	36	or	or	CC
cord-003921-8r8z0otz	15	37	reverse	reverse	VB
cord-003921-8r8z0otz	15	38	migration	migration	NN
cord-003921-8r8z0otz	15	39	into	into	IN
cord-003921-8r8z0otz	15	40	circulation	circulation	NN
cord-003921-8r8z0otz	15	41	.	.	.
cord-003921-8r8z0otz	16	1	In	in	IN
cord-003921-8r8z0otz	16	2	addition	addition	NN
cord-003921-8r8z0otz	16	3	to	to	IN
cord-003921-8r8z0otz	16	4	pro	pro	JJ
cord-003921-8r8z0otz	16	5	-	-	JJ
cord-003921-8r8z0otz	16	6	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	16	7	and	and	CC
cord-003921-8r8z0otz	16	8	tissue	tissue	NN
cord-003921-8r8z0otz	16	9	-	-	HYPH
cord-003921-8r8z0otz	16	10	destructive	destructive	JJ
cord-003921-8r8z0otz	16	11	functions	function	NNS
cord-003921-8r8z0otz	16	12	,	,	,
cord-003921-8r8z0otz	16	13	immune	immune	JJ
cord-003921-8r8z0otz	16	14	regulatory	regulatory	JJ
cord-003921-8r8z0otz	16	15	and	and	CC
cord-003921-8r8z0otz	16	16	tissue	tissue	NN
cord-003921-8r8z0otz	16	17	-	-	HYPH
cord-003921-8r8z0otz	16	18	repairing	repair	VBG
cord-003921-8r8z0otz	16	19	phenotype	phenotype	NN
cord-003921-8r8z0otz	16	20	associated	associate	VBN
cord-003921-8r8z0otz	16	21	with	with	IN
cord-003921-8r8z0otz	16	22	distinct	distinct	JJ
cord-003921-8r8z0otz	16	23	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	16	24	subsets	subset	NNS
cord-003921-8r8z0otz	16	25	have	have	VBP
cord-003921-8r8z0otz	16	26	been	be	VBN
cord-003921-8r8z0otz	16	27	identified	identify	VBN
cord-003921-8r8z0otz	16	28	.	.	.
cord-003921-8r8z0otz	17	1	SUMMARY	summary	NN
cord-003921-8r8z0otz	17	2	:	:	:
cord-003921-8r8z0otz	18	1	Newly	newly	RB
cord-003921-8r8z0otz	18	2	recognized	recognize	VBN
cord-003921-8r8z0otz	18	3	and	and	CC
cord-003921-8r8z0otz	18	4	therapeutically	therapeutically	RB
cord-003921-8r8z0otz	18	5	attractive	attractive	JJ
cord-003921-8r8z0otz	18	6	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	18	7	characteristics	characteristic	NNS
cord-003921-8r8z0otz	18	8	warrant	warrant	VBP
cord-003921-8r8z0otz	18	9	comprehensive	comprehensive	JJ
cord-003921-8r8z0otz	18	10	preclinical	preclinical	JJ
cord-003921-8r8z0otz	18	11	and	and	CC
cord-003921-8r8z0otz	18	12	clinical	clinical	JJ
cord-003921-8r8z0otz	18	13	attention	attention	NN
cord-003921-8r8z0otz	18	14	to	to	TO
cord-003921-8r8z0otz	18	15	target	target	VB
cord-003921-8r8z0otz	18	16	IRI	IRI	NNP
cord-003921-8r8z0otz	18	17	in	in	IN
cord-003921-8r8z0otz	18	18	transplant	transplant	NN
cord-003921-8r8z0otz	18	19	recipients	recipient	NNS
cord-003921-8r8z0otz	18	20	.	.	.
cord-003921-8r8z0otz	19	1	Liver	liver	NN
cord-003921-8r8z0otz	19	2	transplantation	transplantation	NN
cord-003921-8r8z0otz	19	3	(	(	-LRB-
cord-003921-8r8z0otz	19	4	LT	LT	NNP
cord-003921-8r8z0otz	19	5	)	)	-RRB-
cord-003921-8r8z0otz	19	6	has	have	VBZ
cord-003921-8r8z0otz	19	7	become	become	VBN
cord-003921-8r8z0otz	19	8	the	the	DT
cord-003921-8r8z0otz	19	9	standard	standard	NN
cord-003921-8r8z0otz	19	10	of	of	IN
cord-003921-8r8z0otz	19	11	care	care	NN
cord-003921-8r8z0otz	19	12	for	for	IN
cord-003921-8r8z0otz	19	13	patients	patient	NNS
cord-003921-8r8z0otz	19	14	with	with	IN
cord-003921-8r8z0otz	19	15	end	end	NN
cord-003921-8r8z0otz	19	16	-	-	HYPH
cord-003921-8r8z0otz	19	17	stage	stage	NN
cord-003921-8r8z0otz	19	18	liver	liver	NN
cord-003921-8r8z0otz	19	19	disease	disease	NN
cord-003921-8r8z0otz	19	20	and	and	CC
cord-003921-8r8z0otz	19	21	those	those	DT
cord-003921-8r8z0otz	19	22	with	with	IN
cord-003921-8r8z0otz	19	23	liver	liver	NN
cord-003921-8r8z0otz	19	24	malignancies	malignancy	NNS
cord-003921-8r8z0otz	19	25	[	[	-LRB-
cord-003921-8r8z0otz	19	26	1	1	CD
cord-003921-8r8z0otz	19	27	]	]	-RRB-
cord-003921-8r8z0otz	19	28	.	.	.
cord-003921-8r8z0otz	20	1	Hepatic	hepatic	JJ
cord-003921-8r8z0otz	20	2	ischemia	ischemia	NN
cord-003921-8r8z0otz	20	3	-	-	HYPH
cord-003921-8r8z0otz	20	4	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	20	5	injury	injury	NN
cord-003921-8r8z0otz	20	6	(	(	-LRB-
cord-003921-8r8z0otz	20	7	IRI	IRI	NNP
cord-003921-8r8z0otz	20	8	)	)	-RRB-
cord-003921-8r8z0otz	20	9	,	,	,
cord-003921-8r8z0otz	20	10	an	an	DT
cord-003921-8r8z0otz	20	11	inevitable	inevitable	JJ
cord-003921-8r8z0otz	20	12	event	event	NN
cord-003921-8r8z0otz	20	13	during	during	IN
cord-003921-8r8z0otz	20	14	LT	LT	NNP
cord-003921-8r8z0otz	20	15	,	,	,
cord-003921-8r8z0otz	20	16	represents	represent	VBZ
cord-003921-8r8z0otz	20	17	a	a	DT
cord-003921-8r8z0otz	20	18	major	major	JJ
cord-003921-8r8z0otz	20	19	risk	risk	NN
cord-003921-8r8z0otz	20	20	factor	factor	NN
cord-003921-8r8z0otz	20	21	for	for	IN
cord-003921-8r8z0otz	20	22	the	the	DT
cord-003921-8r8z0otz	20	23	primary	primary	JJ
cord-003921-8r8z0otz	20	24	graft	graft	NN
cord-003921-8r8z0otz	20	25	dysfunction	dysfunction	NN
cord-003921-8r8z0otz	20	26	as	as	RB
cord-003921-8r8z0otz	20	27	well	well	RB
cord-003921-8r8z0otz	20	28	as	as	IN
cord-003921-8r8z0otz	20	29	the	the	DT
cord-003921-8r8z0otz	20	30	development	development	NN
cord-003921-8r8z0otz	20	31	of	of	IN
cord-003921-8r8z0otz	20	32	acute	acute	JJ
cord-003921-8r8z0otz	20	33	and	and	CC
cord-003921-8r8z0otz	20	34	chronic	chronic	JJ
cord-003921-8r8z0otz	20	35	rejection	rejection	NN
cord-003921-8r8z0otz	20	36	[	[	-LRB-
cord-003921-8r8z0otz	20	37	2	2	CD
cord-003921-8r8z0otz	20	38	,	,	,
cord-003921-8r8z0otz	20	39	3	3	CD
cord-003921-8r8z0otz	20	40	]	]	-RRB-
cord-003921-8r8z0otz	20	41	.	.	.
cord-003921-8r8z0otz	21	1	Hence	hence	RB
cord-003921-8r8z0otz	21	2	,	,	,
cord-003921-8r8z0otz	21	3	minimizing	minimize	VBG
cord-003921-8r8z0otz	21	4	IRI	IRI	NNP
cord-003921-8r8z0otz	21	5	is	be	VBZ
cord-003921-8r8z0otz	21	6	This	this	DT
cord-003921-8r8z0otz	21	7	article	article	NN
cord-003921-8r8z0otz	21	8	is	be	VBZ
cord-003921-8r8z0otz	21	9	part	part	NN
cord-003921-8r8z0otz	21	10	of	of	IN
cord-003921-8r8z0otz	21	11	the	the	DT
cord-003921-8r8z0otz	21	12	Topical	Topical	NNP
cord-003921-8r8z0otz	21	13	Collection	Collection	NNP
cord-003921-8r8z0otz	21	14	on	on	IN
cord-003921-8r8z0otz	21	15	Immunology	Immunology	NNP
cord-003921-8r8z0otz	22	1	*	*	NFP
cord-003921-8r8z0otz	23	1	Jerzy	Jerzy	NNP
cord-003921-8r8z0otz	23	2	W.	W.	NNP
cord-003921-8r8z0otz	23	3	Kupiec	Kupiec	NNP
cord-003921-8r8z0otz	23	4	-	-	HYPH
cord-003921-8r8z0otz	23	5	Weglinski	Weglinski	NNP
cord-003921-8r8z0otz	23	6	JKUPIEC@MEDNET.UCLA.EDU	JKUPIEC@MEDNET.UCLA.EDU	.
cord-003921-8r8z0otz	24	1	important	important	JJ
cord-003921-8r8z0otz	24	2	not	not	RB
cord-003921-8r8z0otz	24	3	only	only	RB
cord-003921-8r8z0otz	24	4	for	for	IN
cord-003921-8r8z0otz	24	5	improving	improve	VBG
cord-003921-8r8z0otz	24	6	clinical	clinical	JJ
cord-003921-8r8z0otz	24	7	outcomes	outcome	NNS
cord-003921-8r8z0otz	24	8	but	but	CC
cord-003921-8r8z0otz	24	9	also	also	RB
cord-003921-8r8z0otz	24	10	for	for	IN
cord-003921-8r8z0otz	24	11	successful	successful	JJ
cord-003921-8r8z0otz	24	12	use	use	NN
cord-003921-8r8z0otz	24	13	of	of	IN
cord-003921-8r8z0otz	24	14	marginal	marginal	JJ
cord-003921-8r8z0otz	24	15	liver	liver	NN
cord-003921-8r8z0otz	24	16	grafts	graft	NNS
cord-003921-8r8z0otz	24	17	and	and	CC
cord-003921-8r8z0otz	24	18	expansion	expansion	NN
cord-003921-8r8z0otz	24	19	of	of	IN
cord-003921-8r8z0otz	24	20	donor	donor	NN
cord-003921-8r8z0otz	24	21	organ	organ	NN
cord-003921-8r8z0otz	24	22	pool	pool	NN
cord-003921-8r8z0otz	24	23	available	available	JJ
cord-003921-8r8z0otz	24	24	for	for	IN
cord-003921-8r8z0otz	24	25	transplantation	transplantation	NN
cord-003921-8r8z0otz	24	26	.	.	.
cord-003921-8r8z0otz	25	1	Despite	despite	IN
cord-003921-8r8z0otz	25	2	its	-PRON-	PRP$
cord-003921-8r8z0otz	25	3	obvious	obvious	JJ
cord-003921-8r8z0otz	25	4	clinical	clinical	JJ
cord-003921-8r8z0otz	25	5	importance	importance	NN
cord-003921-8r8z0otz	25	6	,	,	,
cord-003921-8r8z0otz	25	7	however	however	RB
cord-003921-8r8z0otz	25	8	,	,	,
cord-003921-8r8z0otz	25	9	the	the	DT
cord-003921-8r8z0otz	25	10	mechanisms	mechanism	NNS
cord-003921-8r8z0otz	25	11	accounting	account	VBG
cord-003921-8r8z0otz	25	12	for	for	IN
cord-003921-8r8z0otz	25	13	liver	liver	NN
cord-003921-8r8z0otz	25	14	IRI	IRI	NNP
cord-003921-8r8z0otz	25	15	are	be	VBP
cord-003921-8r8z0otz	25	16	only	only	RB
cord-003921-8r8z0otz	25	17	partially	partially	RB
cord-003921-8r8z0otz	25	18	understood	understand	VBN
cord-003921-8r8z0otz	25	19	and	and	CC
cord-003921-8r8z0otz	25	20	effective	effective	JJ
cord-003921-8r8z0otz	25	21	preventive	preventive	JJ
cord-003921-8r8z0otz	25	22	or	or	CC
cord-003921-8r8z0otz	25	23	therapeutic	therapeutic	JJ
cord-003921-8r8z0otz	25	24	strategies	strategy	NNS
cord-003921-8r8z0otz	25	25	remain	remain	VBP
cord-003921-8r8z0otz	25	26	to	to	TO
cord-003921-8r8z0otz	25	27	be	be	VB
cord-003921-8r8z0otz	25	28	established	establish	VBN
cord-003921-8r8z0otz	25	29	.	.	.
cord-003921-8r8z0otz	26	1	In	in	IN
cord-003921-8r8z0otz	26	2	the	the	DT
cord-003921-8r8z0otz	26	3	initial	initial	JJ
cord-003921-8r8z0otz	26	4	stage	stage	NN
cord-003921-8r8z0otz	26	5	of	of	IN
cord-003921-8r8z0otz	26	6	liver	liver	NN
cord-003921-8r8z0otz	26	7	IRI	IRI	NNP
cord-003921-8r8z0otz	26	8	,	,	,
cord-003921-8r8z0otz	26	9	ischemic	ischemic	JJ
cord-003921-8r8z0otz	26	10	insult	insult	NN
cord-003921-8r8z0otz	26	11	renders	render	VBZ
cord-003921-8r8z0otz	26	12	hepatic	hepatic	JJ
cord-003921-8r8z0otz	26	13	cells	cell	NNS
cord-003921-8r8z0otz	26	14	sensitive	sensitive	JJ
cord-003921-8r8z0otz	26	15	to	to	IN
cord-003921-8r8z0otz	26	16	glycogen	glycogen	NN
cord-003921-8r8z0otz	26	17	consumption	consumption	NN
cord-003921-8r8z0otz	26	18	,	,	,
cord-003921-8r8z0otz	26	19	oxygen	oxygen	NN
cord-003921-8r8z0otz	26	20	deprivation	deprivation	NN
cord-003921-8r8z0otz	26	21	,	,	,
cord-003921-8r8z0otz	26	22	pH	ph	NN
cord-003921-8r8z0otz	26	23	changes	change	NNS
cord-003921-8r8z0otz	26	24	,	,	,
cord-003921-8r8z0otz	26	25	and	and	CC
cord-003921-8r8z0otz	26	26	adenosine	adenosine	NN
cord-003921-8r8z0otz	26	27	triphosphate	triphosphate	NN
cord-003921-8r8z0otz	26	28	(	(	-LRB-
cord-003921-8r8z0otz	26	29	ATP	ATP	NNP
cord-003921-8r8z0otz	26	30	)	)	-RRB-
cord-003921-8r8z0otz	26	31	depletion	depletion	NN
cord-003921-8r8z0otz	26	32	[	[	-LRB-
cord-003921-8r8z0otz	26	33	4	4	CD
cord-003921-8r8z0otz	26	34	]	]	-RRB-
cord-003921-8r8z0otz	26	35	.	.	.
cord-003921-8r8z0otz	27	1	These	these	DT
cord-003921-8r8z0otz	27	2	are	be	VBP
cord-003921-8r8z0otz	27	3	followed	follow	VBN
cord-003921-8r8z0otz	27	4	by	by	IN
cord-003921-8r8z0otz	27	5	enhanced	enhanced	JJ
cord-003921-8r8z0otz	27	6	production	production	NN
cord-003921-8r8z0otz	27	7	of	of	IN
cord-003921-8r8z0otz	27	8	reactive	reactive	JJ
cord-003921-8r8z0otz	27	9	oxygen	oxygen	NN
cord-003921-8r8z0otz	27	10	species	specie	NNS
cord-003921-8r8z0otz	27	11	(	(	-LRB-
cord-003921-8r8z0otz	27	12	ROS	ROS	NNP
cord-003921-8r8z0otz	27	13	)	)	-RRB-
cord-003921-8r8z0otz	27	14	,	,	,
cord-003921-8r8z0otz	27	15	higher	high	JJR
cord-003921-8r8z0otz	27	16	intracellular	intracellular	JJ
cord-003921-8r8z0otz	27	17	calcium	calcium	NN
cord-003921-8r8z0otz	27	18	concentration	concentration	NN
cord-003921-8r8z0otz	27	19	,	,	,
cord-003921-8r8z0otz	27	20	and	and	CC
cord-003921-8r8z0otz	27	21	organelle	organelle	NN
cord-003921-8r8z0otz	27	22	damage	damage	NN
cord-003921-8r8z0otz	27	23	,	,	,
cord-003921-8r8z0otz	27	24	leading	lead	VBG
cord-003921-8r8z0otz	27	25	to	to	IN
cord-003921-8r8z0otz	27	26	the	the	DT
cord-003921-8r8z0otz	27	27	initial	initial	JJ
cord-003921-8r8z0otz	27	28	parenchymal	parenchymal	JJ
cord-003921-8r8z0otz	27	29	cell	cell	NN
cord-003921-8r8z0otz	27	30	death	death	NN
cord-003921-8r8z0otz	27	31	[	[	-LRB-
cord-003921-8r8z0otz	27	32	5	5	CD
cord-003921-8r8z0otz	27	33	]	]	-RRB-
cord-003921-8r8z0otz	27	34	.	.	.
cord-003921-8r8z0otz	28	1	The	the	DT
cord-003921-8r8z0otz	28	2	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	28	3	itself	-PRON-	PRP
cord-003921-8r8z0otz	28	4	disturbs	disturb	VBZ
cord-003921-8r8z0otz	28	5	liver	liver	NN
cord-003921-8r8z0otz	28	6	metabolism	metabolism	NN
cord-003921-8r8z0otz	28	7	and	and	CC
cord-003921-8r8z0otz	28	8	evokes	evoke	VBZ
cord-003921-8r8z0otz	28	9	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	28	10	cascades	cascade	NNS
cord-003921-8r8z0otz	28	11	leading	lead	VBG
cord-003921-8r8z0otz	28	12	to	to	IN
cord-003921-8r8z0otz	28	13	aggravated	aggravated	JJ
cord-003921-8r8z0otz	28	14	hepatocellular	hepatocellular	JJ
cord-003921-8r8z0otz	28	15	damage	damage	NN
cord-003921-8r8z0otz	28	16	.	.	.
cord-003921-8r8z0otz	29	1	Innate	innate	JJ
cord-003921-8r8z0otz	29	2	immune	immune	JJ
cord-003921-8r8z0otz	29	3	activation	activation	NN
cord-003921-8r8z0otz	29	4	plays	play	VBZ
cord-003921-8r8z0otz	29	5	a	a	DT
cord-003921-8r8z0otz	29	6	central	central	JJ
cord-003921-8r8z0otz	29	7	role	role	NN
cord-003921-8r8z0otz	29	8	in	in	IN
cord-003921-8r8z0otz	29	9	this	this	DT
cord-003921-8r8z0otz	29	10	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	29	11	response	response	NN
cord-003921-8r8z0otz	29	12	via	via	IN
cord-003921-8r8z0otz	29	13	cytotoxic	cytotoxic	JJ
cord-003921-8r8z0otz	29	14	mechanisms	mechanism	NNS
cord-003921-8r8z0otz	29	15	and	and	CC
cord-003921-8r8z0otz	29	16	dynamic	dynamic	JJ
cord-003921-8r8z0otz	29	17	cross	cross	NN
cord-003921-8r8z0otz	29	18	-	-	NN
cord-003921-8r8z0otz	29	19	talk	talk	VB
cord-003921-8r8z0otz	29	20	with	with	IN
cord-003921-8r8z0otz	29	21	adaptive	adaptive	JJ
cord-003921-8r8z0otz	29	22	immune	immune	JJ
cord-003921-8r8z0otz	29	23	cell	cell	NN
cord-003921-8r8z0otz	29	24	repertoires	repertoire	NNS
cord-003921-8r8z0otz	29	25	,	,	,
cord-003921-8r8z0otz	29	26	ultimately	ultimately	RB
cord-003921-8r8z0otz	29	27	converting	convert	VBG
cord-003921-8r8z0otz	29	28	immunologically	immunologically	RB
cord-003921-8r8z0otz	29	29	quiescent	quiescent	JJ
cord-003921-8r8z0otz	29	30	hepatic	hepatic	JJ
cord-003921-8r8z0otz	29	31	milieu	milieu	NN
cord-003921-8r8z0otz	29	32	into	into	IN
cord-003921-8r8z0otz	29	33	an	an	DT
cord-003921-8r8z0otz	29	34	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	29	35	organ	organ	NN
cord-003921-8r8z0otz	29	36	[	[	-LRB-
cord-003921-8r8z0otz	29	37	6	6	CD
cord-003921-8r8z0otz	29	38	,	,	,
cord-003921-8r8z0otz	29	39	7	7	CD
cord-003921-8r8z0otz	29	40	]	]	-RRB-
cord-003921-8r8z0otz	29	41	.	.	.
cord-003921-8r8z0otz	30	1	In	in	IN
cord-003921-8r8z0otz	30	2	unstressed	unstressed	JJ
cord-003921-8r8z0otz	30	3	human	human	JJ
cord-003921-8r8z0otz	30	4	liver	liver	NN
cord-003921-8r8z0otz	30	5	,	,	,
cord-003921-8r8z0otz	30	6	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	30	7	cells	cell	NNS
cord-003921-8r8z0otz	30	8	(	(	-LRB-
cord-003921-8r8z0otz	30	9	liver	liver	NN
cord-003921-8r8z0otz	30	10	-	-	HYPH
cord-003921-8r8z0otz	30	11	resident	resident	NN
cord-003921-8r8z0otz	30	12	macrophages	macrophage	NNS
cord-003921-8r8z0otz	30	13	)	)	-RRB-
cord-003921-8r8z0otz	30	14	account	account	VBP
cord-003921-8r8z0otz	30	15	for	for	IN
cord-003921-8r8z0otz	30	16	about	about	RB
cord-003921-8r8z0otz	30	17	15	15	CD
cord-003921-8r8z0otz	30	18	%	%	NN
cord-003921-8r8z0otz	30	19	of	of	IN
cord-003921-8r8z0otz	30	20	total	total	JJ
cord-003921-8r8z0otz	30	21	hepatocellular	hepatocellular	JJ
cord-003921-8r8z0otz	30	22	population	population	NN
cord-003921-8r8z0otz	30	23	and	and	CC
cord-003921-8r8z0otz	30	24	80	80	CD
cord-003921-8r8z0otz	30	25	-	-	SYM
cord-003921-8r8z0otz	30	26	90	90	CD
cord-003921-8r8z0otz	30	27	%	%	NN
cord-003921-8r8z0otz	30	28	of	of	IN
cord-003921-8r8z0otz	30	29	whole	whole	JJ
cord-003921-8r8z0otz	30	30	body	body	NN
cord-003921-8r8z0otz	30	31	macrophages	macrophage	NNS
cord-003921-8r8z0otz	30	32	[	[	-LRB-
cord-003921-8r8z0otz	30	33	8	8	CD
cord-003921-8r8z0otz	30	34	]	]	-RRB-
cord-003921-8r8z0otz	30	35	.	.	.
cord-003921-8r8z0otz	31	1	In	in	IN
cord-003921-8r8z0otz	31	2	IRI	IRI	NNP
cord-003921-8r8z0otz	31	3	-	-	HYPH
cord-003921-8r8z0otz	31	4	LT	LT	NNP
cord-003921-8r8z0otz	31	5	pathophysiology	pathophysiology	NN
cord-003921-8r8z0otz	31	6	,	,	,
cord-003921-8r8z0otz	31	7	both	both	DT
cord-003921-8r8z0otz	31	8	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	31	9	cells	cell	NNS
cord-003921-8r8z0otz	31	10	(	(	-LRB-
cord-003921-8r8z0otz	31	11	donor	donor	NN
cord-003921-8r8z0otz	31	12	-	-	HYPH
cord-003921-8r8z0otz	31	13	origin	origin	NN
cord-003921-8r8z0otz	31	14	)	)	-RRB-
cord-003921-8r8z0otz	31	15	and	and	CC
cord-003921-8r8z0otz	31	16	liver	liver	NN
cord-003921-8r8z0otz	31	17	-	-	HYPH
cord-003921-8r8z0otz	31	18	infiltrating	infiltrate	VBG
cord-003921-8r8z0otz	31	19	bone	bone	NN
cord-003921-8r8z0otz	31	20	marrow	marrow	NN
cord-003921-8r8z0otz	31	21	-	-	HYPH
cord-003921-8r8z0otz	31	22	derived	derive	VBN
cord-003921-8r8z0otz	31	23	macrophages	macrophage	NNS
cord-003921-8r8z0otz	31	24	(	(	-LRB-
cord-003921-8r8z0otz	31	25	recipient	recipient	NN
cord-003921-8r8z0otz	31	26	-	-	HYPH
cord-003921-8r8z0otz	31	27	origin	origin	NN
cord-003921-8r8z0otz	31	28	)	)	-RRB-
cord-003921-8r8z0otz	31	29	play	play	VB
cord-003921-8r8z0otz	31	30	dominant	dominant	JJ
cord-003921-8r8z0otz	31	31	roles	role	NNS
cord-003921-8r8z0otz	31	32	in	in	IN
cord-003921-8r8z0otz	31	33	priming	prime	VBG
cord-003921-8r8z0otz	31	34	innate	innate	JJ
cord-003921-8r8z0otz	31	35	immune	immune	JJ
cord-003921-8r8z0otz	31	36	responses	response	NNS
cord-003921-8r8z0otz	31	37	[	[	-LRB-
cord-003921-8r8z0otz	31	38	9	9	CD
cord-003921-8r8z0otz	31	39	]	]	-RRB-
cord-003921-8r8z0otz	31	40	[	[	-LRB-
cord-003921-8r8z0otz	31	41	10	10	CD
cord-003921-8r8z0otz	31	42	]	]	-RRB-
cord-003921-8r8z0otz	31	43	[	[	-LRB-
cord-003921-8r8z0otz	31	44	11	11	CD
cord-003921-8r8z0otz	31	45	]	]	-RRB-
cord-003921-8r8z0otz	31	46	,	,	,
cord-003921-8r8z0otz	31	47	with	with	IN
cord-003921-8r8z0otz	31	48	the	the	DT
cord-003921-8r8z0otz	31	49	majority	majority	NN
cord-003921-8r8z0otz	31	50	of	of	IN
cord-003921-8r8z0otz	31	51	studies	study	NNS
cord-003921-8r8z0otz	31	52	focusing	focus	VBG
cord-003921-8r8z0otz	31	53	on	on	IN
cord-003921-8r8z0otz	31	54	macrophage	macrophage	NN
cord-003921-8r8z0otz	31	55	regulation	regulation	NN
cord-003921-8r8z0otz	31	56	[	[	-LRB-
cord-003921-8r8z0otz	31	57	12	12	CD
cord-003921-8r8z0otz	31	58	,	,	,
cord-003921-8r8z0otz	31	59	13	13	CD
cord-003921-8r8z0otz	31	60	]	]	-RRB-
cord-003921-8r8z0otz	31	61	.	.	.
cord-003921-8r8z0otz	32	1	On	on	IN
cord-003921-8r8z0otz	32	2	the	the	DT
cord-003921-8r8z0otz	32	3	other	other	JJ
cord-003921-8r8z0otz	32	4	hand	hand	NN
cord-003921-8r8z0otz	32	5	,	,	,
cord-003921-8r8z0otz	32	6	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	32	7	are	be	VBP
cord-003921-8r8z0otz	32	8	dominant	dominant	JJ
cord-003921-8r8z0otz	32	9	immune	immune	JJ
cord-003921-8r8z0otz	32	10	cells	cell	NNS
cord-003921-8r8z0otz	32	11	in	in	IN
cord-003921-8r8z0otz	32	12	the	the	DT
cord-003921-8r8z0otz	32	13	steady	steady	JJ
cord-003921-8r8z0otz	32	14	-	-	HYPH
cord-003921-8r8z0otz	32	15	state	state	NN
cord-003921-8r8z0otz	32	16	blood	blood	NN
cord-003921-8r8z0otz	32	17	circulation	circulation	NN
cord-003921-8r8z0otz	32	18	(	(	-LRB-
cord-003921-8r8z0otz	32	19	50	50	CD
cord-003921-8r8z0otz	32	20	-	-	SYM
cord-003921-8r8z0otz	32	21	70	70	CD
cord-003921-8r8z0otz	32	22	%	%	NN
cord-003921-8r8z0otz	32	23	in	in	IN
cord-003921-8r8z0otz	32	24	human	human	NN
cord-003921-8r8z0otz	32	25	,	,	,
cord-003921-8r8z0otz	32	26	10	10	CD
cord-003921-8r8z0otz	32	27	-	-	SYM
cord-003921-8r8z0otz	32	28	25	25	CD
cord-003921-8r8z0otz	32	29	%	%	NN
cord-003921-8r8z0otz	32	30	in	in	IN
cord-003921-8r8z0otz	32	31	mouse	mouse	NN
cord-003921-8r8z0otz	32	32	[	[	-LRB-
cord-003921-8r8z0otz	32	33	14	14	CD
cord-003921-8r8z0otz	32	34	,	,	,
cord-003921-8r8z0otz	32	35	15	15	CD
cord-003921-8r8z0otz	32	36	]	]	-RRB-
cord-003921-8r8z0otz	32	37	)	)	-RRB-
cord-003921-8r8z0otz	32	38	,	,	,
cord-003921-8r8z0otz	32	39	constantly	constantly	RB
cord-003921-8r8z0otz	32	40	patrolling	patrol	VBG
cord-003921-8r8z0otz	32	41	and	and	CC
cord-003921-8r8z0otz	32	42	serving	serve	VBG
cord-003921-8r8z0otz	32	43	as	as	IN
cord-003921-8r8z0otz	32	44	the	the	DT
cord-003921-8r8z0otz	32	45	first	first	JJ
cord-003921-8r8z0otz	32	46	line	line	NN
cord-003921-8r8z0otz	32	47	of	of	IN
cord-003921-8r8z0otz	32	48	defense	defense	NN
cord-003921-8r8z0otz	32	49	against	against	IN
cord-003921-8r8z0otz	32	50	invading	invade	VBG
cord-003921-8r8z0otz	32	51	pathogens	pathogen	NNS
cord-003921-8r8z0otz	32	52	[	[	-LRB-
cord-003921-8r8z0otz	32	53	16	16	CD
cord-003921-8r8z0otz	32	54	]	]	-RRB-
cord-003921-8r8z0otz	32	55	.	.	.
cord-003921-8r8z0otz	33	1	Likewise	likewise	RB
cord-003921-8r8z0otz	33	2	,	,	,
cord-003921-8r8z0otz	33	3	in	in	IN
cord-003921-8r8z0otz	33	4	IR	IR	NNP
cord-003921-8r8z0otz	33	5	-	-	HYPH
cord-003921-8r8z0otz	33	6	stressed	stress	VBN
cord-003921-8r8z0otz	33	7	blood	blood	NN
cord-003921-8r8z0otz	33	8	-	-	HYPH
cord-003921-8r8z0otz	33	9	perfused	perfuse	VBN
cord-003921-8r8z0otz	33	10	liver	liver	NN
cord-003921-8r8z0otz	33	11	,	,	,
cord-003921-8r8z0otz	33	12	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	33	13	are	be	VBP
cord-003921-8r8z0otz	33	14	recruited	recruit	VBN
cord-003921-8r8z0otz	33	15	to	to	IN
cord-003921-8r8z0otz	33	16	the	the	DT
cord-003921-8r8z0otz	33	17	injury	injury	NN
cord-003921-8r8z0otz	33	18	site	site	NN
cord-003921-8r8z0otz	33	19	,	,	,
cord-003921-8r8z0otz	33	20	contributing	contribute	VBG
cord-003921-8r8z0otz	33	21	to	to	IN
cord-003921-8r8z0otz	33	22	sterile	sterile	JJ
cord-003921-8r8z0otz	33	23	inflammation	inflammation	NN
cord-003921-8r8z0otz	33	24	and	and	CC
cord-003921-8r8z0otz	33	25	enhancing	enhance	VBG
cord-003921-8r8z0otz	33	26	the	the	DT
cord-003921-8r8z0otz	33	27	hepatocellular	hepatocellular	JJ
cord-003921-8r8z0otz	33	28	damage	damage	NN
cord-003921-8r8z0otz	33	29	.	.	.
cord-003921-8r8z0otz	34	1	Indeed	indeed	RB
cord-003921-8r8z0otz	34	2	,	,	,
cord-003921-8r8z0otz	34	3	despite	despite	IN
cord-003921-8r8z0otz	34	4	being	be	VBG
cord-003921-8r8z0otz	34	5	long	long	RB
cord-003921-8r8z0otz	34	6	considered	consider	VBN
cord-003921-8r8z0otz	34	7	as	as	IN
cord-003921-8r8z0otz	34	8	"	"	``
cord-003921-8r8z0otz	34	9	non	non	JJ
cord-003921-8r8z0otz	34	10	-	-	JJ
cord-003921-8r8z0otz	34	11	specialized	specialized	JJ
cord-003921-8r8z0otz	34	12	"	"	''
cord-003921-8r8z0otz	34	13	innate	innate	JJ
cord-003921-8r8z0otz	34	14	effector	effector	NN
cord-003921-8r8z0otz	34	15	cells	cell	NNS
cord-003921-8r8z0otz	34	16	,	,	,
cord-003921-8r8z0otz	34	17	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	34	18	infiltration	infiltration	NN
cord-003921-8r8z0otz	34	19	into	into	IN
cord-003921-8r8z0otz	34	20	hepatic	hepatic	JJ
cord-003921-8r8z0otz	34	21	sinusoidal	sinusoidal	JJ
cord-003921-8r8z0otz	34	22	lumen	lumen	NN
cord-003921-8r8z0otz	34	23	is	be	VBZ
cord-003921-8r8z0otz	34	24	now	now	RB
cord-003921-8r8z0otz	34	25	considered	consider	VBN
cord-003921-8r8z0otz	34	26	as	as	IN
cord-003921-8r8z0otz	34	27	one	one	CD
cord-003921-8r8z0otz	34	28	of	of	IN
cord-003921-8r8z0otz	34	29	reliable	reliable	JJ
cord-003921-8r8z0otz	34	30	biomarkers	biomarker	NNS
cord-003921-8r8z0otz	34	31	of	of	IN
cord-003921-8r8z0otz	34	32	liver	liver	NN
cord-003921-8r8z0otz	34	33	IRI	IRI	NNP
cord-003921-8r8z0otz	34	34	[	[	-LRB-
cord-003921-8r8z0otz	34	35	17	17	CD
cord-003921-8r8z0otz	34	36	,	,	,
cord-003921-8r8z0otz	34	37	18	18	CD
cord-003921-8r8z0otz	34	38	]	]	-RRB-
cord-003921-8r8z0otz	34	39	.	.	.
cord-003921-8r8z0otz	35	1	In	in	IN
cord-003921-8r8z0otz	35	2	this	this	DT
cord-003921-8r8z0otz	35	3	review	review	NN
cord-003921-8r8z0otz	35	4	,	,	,
cord-003921-8r8z0otz	35	5	we	-PRON-	PRP
cord-003921-8r8z0otz	35	6	first	first	RB
cord-003921-8r8z0otz	35	7	summarize	summarize	VBP
cord-003921-8r8z0otz	35	8	progress	progress	NN
cord-003921-8r8z0otz	35	9	in	in	IN
cord-003921-8r8z0otz	35	10	our	-PRON-	PRP$
cord-003921-8r8z0otz	35	11	appreciation	appreciation	NN
cord-003921-8r8z0otz	35	12	of	of	IN
cord-003921-8r8z0otz	35	13	the	the	DT
cord-003921-8r8z0otz	35	14	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	35	15	biology	biology	NN
cord-003921-8r8z0otz	35	16	,	,	,
cord-003921-8r8z0otz	35	17	and	and	CC
cord-003921-8r8z0otz	35	18	then	then	RB
cord-003921-8r8z0otz	35	19	discuss	discuss	VB
cord-003921-8r8z0otz	35	20	therapeutic	therapeutic	JJ
cord-003921-8r8z0otz	35	21	prospects	prospect	NNS
cord-003921-8r8z0otz	35	22	of	of	IN
cord-003921-8r8z0otz	35	23	their	-PRON-	PRP$
cord-003921-8r8z0otz	35	24	targeting	targeting	NN
cord-003921-8r8z0otz	35	25	for	for	IN
cord-003921-8r8z0otz	35	26	the	the	DT
cord-003921-8r8z0otz	35	27	treatment	treatment	NN
cord-003921-8r8z0otz	35	28	of	of	IN
cord-003921-8r8z0otz	35	29	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	35	30	states	state	NNS
cord-003921-8r8z0otz	35	31	,	,	,
cord-003921-8r8z0otz	35	32	such	such	JJ
cord-003921-8r8z0otz	35	33	as	as	IN
cord-003921-8r8z0otz	35	34	IRI	IRI	NNP
cord-003921-8r8z0otz	35	35	in	in	IN
cord-003921-8r8z0otz	35	36	LT	LT	NNP
cord-003921-8r8z0otz	35	37	recipients	recipient	NNS
cord-003921-8r8z0otz	35	38	.	.	.
cord-003921-8r8z0otz	36	1	Neutrophils	neutrophils	NN
cord-003921-8r8z0otz	36	2	,	,	,
cord-003921-8r8z0otz	36	3	the	the	DT
cord-003921-8r8z0otz	36	4	largest	large	JJS
cord-003921-8r8z0otz	36	5	circulating	circulating	JJ
cord-003921-8r8z0otz	36	6	fraction	fraction	NN
cord-003921-8r8z0otz	36	7	of	of	IN
cord-003921-8r8z0otz	36	8	leukocytes	leukocyte	NNS
cord-003921-8r8z0otz	36	9	,	,	,
cord-003921-8r8z0otz	36	10	are	be	VBP
cord-003921-8r8z0otz	36	11	continuously	continuously	RB
cord-003921-8r8z0otz	36	12	generated	generate	VBN
cord-003921-8r8z0otz	36	13	from	from	IN
cord-003921-8r8z0otz	36	14	myeloid	myeloid	JJ
cord-003921-8r8z0otz	36	15	precursors	precursor	NNS
cord-003921-8r8z0otz	36	16	in	in	IN
cord-003921-8r8z0otz	36	17	the	the	DT
cord-003921-8r8z0otz	36	18	bone	bone	NN
cord-003921-8r8z0otz	36	19	marrow	marrow	NN
cord-003921-8r8z0otz	36	20	in	in	IN
cord-003921-8r8z0otz	36	21	a	a	DT
cord-003921-8r8z0otz	36	22	process	process	NN
cord-003921-8r8z0otz	36	23	of	of	IN
cord-003921-8r8z0otz	36	24	"	"	``
cord-003921-8r8z0otz	36	25	granulopoiesis	granulopoiesis	NNP
cord-003921-8r8z0otz	36	26	"	"	''
cord-003921-8r8z0otz	37	1	(	(	-LRB-
cord-003921-8r8z0otz	37	2	daily	daily	JJ
cord-003921-8r8z0otz	37	3	production	production	NN
cord-003921-8r8z0otz	37	4	reaches	reach	VBZ
cord-003921-8r8z0otz	37	5	up	up	IN
cord-003921-8r8z0otz	37	6	to	to	TO
cord-003921-8r8z0otz	37	7	2	2	CD
cord-003921-8r8z0otz	37	8	×	×	CD
cord-003921-8r8z0otz	37	9	10	10	CD
cord-003921-8r8z0otz	37	10	11	11	CD
cord-003921-8r8z0otz	37	11	cells	cell	NNS
cord-003921-8r8z0otz	37	12	)	)	-RRB-
cord-003921-8r8z0otz	37	13	[	[	-LRB-
cord-003921-8r8z0otz	37	14	16	16	CD
cord-003921-8r8z0otz	37	15	,	,	,
cord-003921-8r8z0otz	37	16	19	19	CD
cord-003921-8r8z0otz	37	17	]	]	-RRB-
cord-003921-8r8z0otz	37	18	.	.	.
cord-003921-8r8z0otz	38	1	The	the	DT
cord-003921-8r8z0otz	38	2	crucial	crucial	JJ
cord-003921-8r8z0otz	38	3	signals	signal	NNS
cord-003921-8r8z0otz	38	4	for	for	IN
cord-003921-8r8z0otz	38	5	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	38	6	activation	activation	NN
cord-003921-8r8z0otz	38	7	are	be	VBP
cord-003921-8r8z0otz	38	8	provided	provide	VBN
cord-003921-8r8z0otz	38	9	by	by	IN
cord-003921-8r8z0otz	38	10	danger	danger	NN
cord-003921-8r8z0otz	38	11	-	-	HYPH
cord-003921-8r8z0otz	38	12	associated	associate	VBN
cord-003921-8r8z0otz	38	13	molecular	molecular	JJ
cord-003921-8r8z0otz	38	14	patterns	pattern	NNS
cord-003921-8r8z0otz	38	15	(	(	-LRB-
cord-003921-8r8z0otz	38	16	DAMPs	damp	NNS
cord-003921-8r8z0otz	38	17	)	)	-RRB-
cord-003921-8r8z0otz	38	18	,	,	,
cord-003921-8r8z0otz	38	19	i.e.	i.e.	FW
cord-003921-8r8z0otz	38	20	,	,	,
cord-003921-8r8z0otz	38	21	endogenous	endogenous	JJ
cord-003921-8r8z0otz	38	22	molecules	molecule	NNS
cord-003921-8r8z0otz	38	23	constitutively	constitutively	RB
cord-003921-8r8z0otz	38	24	expressed	express	VBN
cord-003921-8r8z0otz	38	25	in	in	IN
cord-003921-8r8z0otz	38	26	nuclear	nuclear	JJ
cord-003921-8r8z0otz	38	27	,	,	,
cord-003921-8r8z0otz	38	28	cytoplasm	cytoplasm	JJ
cord-003921-8r8z0otz	38	29	,	,	,
cord-003921-8r8z0otz	38	30	and	and	CC
cord-003921-8r8z0otz	38	31	extracellular	extracellular	JJ
cord-003921-8r8z0otz	38	32	matrix	matrix	NN
cord-003921-8r8z0otz	38	33	under	under	IN
cord-003921-8r8z0otz	38	34	basal	basal	NN
cord-003921-8r8z0otz	38	35	conditions	condition	NNS
cord-003921-8r8z0otz	38	36	.	.	.
cord-003921-8r8z0otz	39	1	Although	although	IN
cord-003921-8r8z0otz	39	2	indispensable	indispensable	JJ
cord-003921-8r8z0otz	39	3	for	for	IN
cord-003921-8r8z0otz	39	4	homeostasis	homeostasis	NN
cord-003921-8r8z0otz	39	5	maintenance	maintenance	NN
cord-003921-8r8z0otz	39	6	,	,	,
cord-003921-8r8z0otz	39	7	once	once	RB
cord-003921-8r8z0otz	39	8	released	release	VBN
cord-003921-8r8z0otz	39	9	in	in	IN
cord-003921-8r8z0otz	39	10	response	response	NN
cord-003921-8r8z0otz	39	11	to	to	IN
cord-003921-8r8z0otz	39	12	tissue	tissue	NN
cord-003921-8r8z0otz	39	13	injury	injury	NN
cord-003921-8r8z0otz	39	14	,	,	,
cord-003921-8r8z0otz	39	15	DAMPs	damp	NNS
cord-003921-8r8z0otz	39	16	are	be	VBP
cord-003921-8r8z0otz	39	17	detected	detect	VBN
cord-003921-8r8z0otz	39	18	by	by	IN
cord-003921-8r8z0otz	39	19	and	and	CC
cord-003921-8r8z0otz	39	20	become	become	VB
cord-003921-8r8z0otz	39	21	critical	critical	JJ
cord-003921-8r8z0otz	39	22	triggers	trigger	NNS
cord-003921-8r8z0otz	39	23	of	of	IN
cord-003921-8r8z0otz	39	24	the	the	DT
cord-003921-8r8z0otz	39	25	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	39	26	cell	cell	NN
cord-003921-8r8z0otz	39	27	activation	activation	NN
cord-003921-8r8z0otz	39	28	.	.	.
cord-003921-8r8z0otz	40	1	A	a	DT
cord-003921-8r8z0otz	40	2	growing	grow	VBG
cord-003921-8r8z0otz	40	3	number	number	NN
cord-003921-8r8z0otz	40	4	of	of	IN
cord-003921-8r8z0otz	40	5	DAMPs	damp	NNS
cord-003921-8r8z0otz	40	6	have	have	VBP
cord-003921-8r8z0otz	40	7	been	be	VBN
cord-003921-8r8z0otz	40	8	identified	identify	VBN
cord-003921-8r8z0otz	40	9	to	to	IN
cord-003921-8r8z0otz	40	10	date	date	NN
cord-003921-8r8z0otz	40	11	,	,	,
cord-003921-8r8z0otz	40	12	such	such	JJ
cord-003921-8r8z0otz	40	13	as	as	IN
cord-003921-8r8z0otz	40	14	ATP	ATP	NNP
cord-003921-8r8z0otz	40	15	,	,	,
cord-003921-8r8z0otz	40	16	histone	histone	NN
cord-003921-8r8z0otz	40	17	,	,	,
cord-003921-8r8z0otz	40	18	high	high	JJ
cord-003921-8r8z0otz	40	19	mobility	mobility	NN
cord-003921-8r8z0otz	40	20	group	group	NN
cord-003921-8r8z0otz	40	21	box	box	NN
cord-003921-8r8z0otz	40	22	1	1	CD
cord-003921-8r8z0otz	40	23	(	(	-LRB-
cord-003921-8r8z0otz	40	24	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	40	25	)	)	-RRB-
cord-003921-8r8z0otz	40	26	,	,	,
cord-003921-8r8z0otz	40	27	with	with	IN
cord-003921-8r8z0otz	40	28	complementary	complementary	JJ
cord-003921-8r8z0otz	40	29	pattern	pattern	NN
cord-003921-8r8z0otz	40	30	recognition	recognition	NN
cord-003921-8r8z0otz	40	31	receptors	receptor	NNS
cord-003921-8r8z0otz	40	32	(	(	-LRB-
cord-003921-8r8z0otz	40	33	PRRs	PRRs	NNP
cord-003921-8r8z0otz	40	34	)	)	-RRB-
cord-003921-8r8z0otz	40	35	crucial	crucial	JJ
cord-003921-8r8z0otz	40	36	in	in	IN
cord-003921-8r8z0otz	40	37	cell	cell	NN
cord-003921-8r8z0otz	40	38	recognition	recognition	NN
cord-003921-8r8z0otz	40	39	and	and	CC
cord-003921-8r8z0otz	40	40	signaling	signal	VBG
cord-003921-8r8z0otz	40	41	pathways	pathway	NNS
cord-003921-8r8z0otz	40	42	(	(	-LRB-
cord-003921-8r8z0otz	40	43	representative	representative	NN
cord-003921-8r8z0otz	40	44	are	be	VBP
cord-003921-8r8z0otz	40	45	listed	list	VBN
cord-003921-8r8z0otz	40	46	in	in	IN
cord-003921-8r8z0otz	40	47	Table	Table	NNP
cord-003921-8r8z0otz	40	48	1	1	CD
cord-003921-8r8z0otz	40	49	)	)	-RRB-
cord-003921-8r8z0otz	40	50	.	.	.
cord-003921-8r8z0otz	41	1	The	the	DT
cord-003921-8r8z0otz	41	2	initial	initial	JJ
cord-003921-8r8z0otz	41	3	parenchymal	parenchymal	NN
cord-003921-8r8z0otz	41	4	cell	cell	NN
cord-003921-8r8z0otz	41	5	damage	damage	NN
cord-003921-8r8z0otz	41	6	results	result	NNS
cord-003921-8r8z0otz	41	7	in	in	IN
cord-003921-8r8z0otz	41	8	the	the	DT
cord-003921-8r8z0otz	41	9	release	release	NN
cord-003921-8r8z0otz	41	10	of	of	IN
cord-003921-8r8z0otz	41	11	DAMPs	damp	NNS
cord-003921-8r8z0otz	41	12	from	from	IN
cord-003921-8r8z0otz	41	13	damaged	damage	VBN
cord-003921-8r8z0otz	41	14	/	/	SYM
cord-003921-8r8z0otz	41	15	dead	dead	JJ
cord-003921-8r8z0otz	41	16	/	/	SYM
cord-003921-8r8z0otz	41	17	moribund	moribund	JJ
cord-003921-8r8z0otz	41	18	cells	cell	NNS
cord-003921-8r8z0otz	41	19	that	that	WDT
cord-003921-8r8z0otz	41	20	stimulate	stimulate	VBP
cord-003921-8r8z0otz	41	21	local	local	JJ
cord-003921-8r8z0otz	41	22	sentinel	sentinel	NN
cord-003921-8r8z0otz	41	23	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	41	24	cells	cell	NNS
cord-003921-8r8z0otz	41	25	and	and	CC
cord-003921-8r8z0otz	41	26	liver	liver	NN
cord-003921-8r8z0otz	41	27	sinusoidal	sinusoidal	NN
cord-003921-8r8z0otz	41	28	endothelial	endothelial	JJ
cord-003921-8r8z0otz	41	29	cells	cell	NNS
cord-003921-8r8z0otz	41	30	(	(	-LRB-
cord-003921-8r8z0otz	41	31	LSECs	lsec	NNS
cord-003921-8r8z0otz	41	32	)	)	-RRB-
cord-003921-8r8z0otz	41	33	.	.	.
cord-003921-8r8z0otz	42	1	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	42	2	cells	cell	NNS
cord-003921-8r8z0otz	42	3	sense	sense	VBP
cord-003921-8r8z0otz	42	4	neighboring	neighbor	VBG
cord-003921-8r8z0otz	42	5	cell	cell	NN
cord-003921-8r8z0otz	42	6	death	death	NN
cord-003921-8r8z0otz	42	7	by	by	IN
cord-003921-8r8z0otz	42	8	receiving	receive	VBG
cord-003921-8r8z0otz	42	9	DAMPs	damp	NNS
cord-003921-8r8z0otz	42	10	signals	signal	NNS
cord-003921-8r8z0otz	42	11	and	and	CC
cord-003921-8r8z0otz	42	12	produce	produce	VB
cord-003921-8r8z0otz	42	13	IL1β	IL1β	NNP
cord-003921-8r8z0otz	42	14	,	,	,
cord-003921-8r8z0otz	42	15	which	which	WDT
cord-003921-8r8z0otz	42	16	up	up	RB
cord-003921-8r8z0otz	42	17	-	-	HYPH
cord-003921-8r8z0otz	42	18	regulates	regulate	VBZ
cord-003921-8r8z0otz	42	19	intercellular	intercellular	JJ
cord-003921-8r8z0otz	42	20	adhesion	adhesion	NN
cord-003921-8r8z0otz	42	21	molecule-1	molecule-1	NN
cord-003921-8r8z0otz	42	22	(	(	-LRB-
cord-003921-8r8z0otz	42	23	ICAM-1	ICAM-1	NNP
cord-003921-8r8z0otz	42	24	)	)	-RRB-
cord-003921-8r8z0otz	42	25	on	on	IN
cord-003921-8r8z0otz	42	26	LSECs	lsec	NNS
cord-003921-8r8z0otz	42	27	.	.	.
cord-003921-8r8z0otz	43	1	Neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	43	2	are	be	VBP
cord-003921-8r8z0otz	43	3	then	then	RB
cord-003921-8r8z0otz	43	4	recruited	recruit	VBN
cord-003921-8r8z0otz	43	5	via	via	IN
cord-003921-8r8z0otz	43	6	integrin	integrin	NN
cord-003921-8r8z0otz	44	1	αMβ2	αMβ2	VBN
cord-003921-8r8z0otz	44	2	(	(	-LRB-
cord-003921-8r8z0otz	44	3	Mac1)-dependent	mac1)-dependent	NN
cord-003921-8r8z0otz	44	4	adhesion	adhesion	NN
cord-003921-8r8z0otz	44	5	to	to	IN
cord-003921-8r8z0otz	44	6	endothelial	endothelial	JJ
cord-003921-8r8z0otz	44	7	ICAM-1	icam-1	NN
cord-003921-8r8z0otz	44	8	.	.	.
cord-003921-8r8z0otz	45	1	This	this	DT
cord-003921-8r8z0otz	45	2	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	45	3	adhesion	adhesion	NN
cord-003921-8r8z0otz	45	4	mechanism	mechanism	NN
cord-003921-8r8z0otz	45	5	requires	require	VBZ
cord-003921-8r8z0otz	45	6	ATP	ATP	NNP
cord-003921-8r8z0otz	45	7	-	-	HYPH
cord-003921-8r8z0otz	45	8	induced	induce	VBN
cord-003921-8r8z0otz	45	9	activation	activation	NN
cord-003921-8r8z0otz	45	10	of	of	IN
cord-003921-8r8z0otz	45	11	P2X7	P2X7	NNP
cord-003921-8r8z0otz	45	12	receptor	receptor	NN
cord-003921-8r8z0otz	45	13	and	and	CC
cord-003921-8r8z0otz	45	14	NOD	nod	NN
cord-003921-8r8z0otz	45	15	-	-	HYPH
cord-003921-8r8z0otz	45	16	like	like	JJ
cord-003921-8r8z0otz	45	17	receptor	receptor	NN
cord-003921-8r8z0otz	46	1	pyrin	pyrin	NNP
cord-003921-8r8z0otz	46	2	domaincontaining-3	domaincontaining-3	NNP
cord-003921-8r8z0otz	47	1	(	(	-LRB-
cord-003921-8r8z0otz	47	2	NLRP3	NLRP3	NNP
cord-003921-8r8z0otz	47	3	)	)	-RRB-
cord-003921-8r8z0otz	47	4	inflammasome	inflammasome	NNP
cord-003921-8r8z0otz	47	5	[	[	-LRB-
cord-003921-8r8z0otz	47	6	20	20	CD
cord-003921-8r8z0otz	47	7	]	]	-RRB-
cord-003921-8r8z0otz	47	8	.	.	.
cord-003921-8r8z0otz	48	1	Indeed	indeed	RB
cord-003921-8r8z0otz	48	2	,	,	,
cord-003921-8r8z0otz	48	3	mice	mouse	NNS
cord-003921-8r8z0otz	48	4	depleted	deplete	VBN
cord-003921-8r8z0otz	48	5	of	of	IN
cord-003921-8r8z0otz	48	6	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	48	7	cells	cell	NNS
cord-003921-8r8z0otz	48	8	by	by	IN
cord-003921-8r8z0otz	48	9	clodronate	clodronate	NN
cord-003921-8r8z0otz	48	10	showed	show	VBD
cord-003921-8r8z0otz	48	11	reduced	reduce	VBN
cord-003921-8r8z0otz	48	12	caspase	caspase	NN
cord-003921-8r8z0otz	48	13	,	,	,
cord-003921-8r8z0otz	48	14	IL1	IL1	NNP
cord-003921-8r8z0otz	48	15	,	,	,
cord-003921-8r8z0otz	48	16	and	and	CC
cord-003921-8r8z0otz	48	17	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	48	18	recruitment	recruitment	NN
cord-003921-8r8z0otz	48	19	,	,	,
cord-003921-8r8z0otz	48	20	whereas	whereas	IN
cord-003921-8r8z0otz	48	21	impaired	impaired	JJ
cord-003921-8r8z0otz	48	22	P2X7R	P2X7R	NNP
cord-003921-8r8z0otz	48	23	signaling	signal	VBG
cord-003921-8r8z0otz	48	24	was	be	VBD
cord-003921-8r8z0otz	48	25	accompanied	accompany	VBN
cord-003921-8r8z0otz	48	26	by	by	IN
cord-003921-8r8z0otz	48	27	equivalently	equivalently	RB
cord-003921-8r8z0otz	48	28	impaired	impair	VBN
cord-003921-8r8z0otz	48	29	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	48	30	accumulation	accumulation	NN
cord-003921-8r8z0otz	48	31	in	in	IN
cord-003921-8r8z0otz	48	32	a	a	DT
cord-003921-8r8z0otz	48	33	liver	liver	NN
cord-003921-8r8z0otz	48	34	thermal	thermal	JJ
cord-003921-8r8z0otz	48	35	injury	injury	NN
cord-003921-8r8z0otz	48	36	model	model	NN
cord-003921-8r8z0otz	48	37	[	[	-LRB-
cord-003921-8r8z0otz	48	38	21	21	CD
cord-003921-8r8z0otz	48	39	]	]	-RRB-
cord-003921-8r8z0otz	48	40	.	.	.
cord-003921-8r8z0otz	49	1	Activated	Activated	NNP
cord-003921-8r8z0otz	49	2	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	49	3	cells	cell	NNS
cord-003921-8r8z0otz	49	4	,	,	,
cord-003921-8r8z0otz	49	5	along	along	IN
cord-003921-8r8z0otz	49	6	with	with	IN
cord-003921-8r8z0otz	49	7	parenchymal	parenchymal	NN
cord-003921-8r8z0otz	49	8	cells	cell	NNS
cord-003921-8r8z0otz	49	9	,	,	,
cord-003921-8r8z0otz	49	10	also	also	RB
cord-003921-8r8z0otz	49	11	release	release	VBP
cord-003921-8r8z0otz	49	12	chemokines	chemokine	NNS
cord-003921-8r8z0otz	49	13	detected	detect	VBN
cord-003921-8r8z0otz	49	14	by	by	IN
cord-003921-8r8z0otz	49	15	G	g	NN
cord-003921-8r8z0otz	49	16	protein	protein	NN
cord-003921-8r8z0otz	49	17	coupled	couple	VBN
cord-003921-8r8z0otz	49	18	receptors	receptor	NNS
cord-003921-8r8z0otz	49	19	(	(	-LRB-
cord-003921-8r8z0otz	49	20	e.g.	e.g.	RB
cord-003921-8r8z0otz	49	21	,	,	,
cord-003921-8r8z0otz	49	22	CXCR2	cxcr2	NN
cord-003921-8r8z0otz	49	23	)	)	-RRB-
cord-003921-8r8z0otz	49	24	on	on	IN
cord-003921-8r8z0otz	49	25	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	49	26	and	and	CC
cord-003921-8r8z0otz	49	27	thereby	thereby	RB
cord-003921-8r8z0otz	49	28	recruit	recruit	VB
cord-003921-8r8z0otz	49	29	them	-PRON-	PRP
cord-003921-8r8z0otz	49	30	to	to	IN
cord-003921-8r8z0otz	49	31	the	the	DT
cord-003921-8r8z0otz	49	32	site	site	NN
cord-003921-8r8z0otz	49	33	of	of	IN
cord-003921-8r8z0otz	49	34	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	49	35	damage	damage	NN
cord-003921-8r8z0otz	49	36	.	.	.
cord-003921-8r8z0otz	50	1	In	in	IN
cord-003921-8r8z0otz	50	2	addition	addition	NN
cord-003921-8r8z0otz	50	3	,	,	,
cord-003921-8r8z0otz	50	4	LSECs	lsec	NNS
cord-003921-8r8z0otz	50	5	themselves	-PRON-	PRP
cord-003921-8r8z0otz	50	6	can	can	MD
cord-003921-8r8z0otz	50	7	sense	sense	VB
cord-003921-8r8z0otz	50	8	DAMPs	damp	NNS
cord-003921-8r8z0otz	50	9	via	via	IN
cord-003921-8r8z0otz	50	10	TLR9	TLR9	NNP
cord-003921-8r8z0otz	50	11	to	to	TO
cord-003921-8r8z0otz	50	12	release	release	VB
cord-003921-8r8z0otz	50	13	IL1β	IL1β	NNP
cord-003921-8r8z0otz	50	14	and	and	CC
cord-003921-8r8z0otz	50	15	IL18	IL18	NNP
cord-003921-8r8z0otz	50	16	[	[	-LRB-
cord-003921-8r8z0otz	50	17	22	22	CD
cord-003921-8r8z0otz	50	18	]	]	-RRB-
cord-003921-8r8z0otz	51	1	(	(	-LRB-
cord-003921-8r8z0otz	51	2	Fig	Fig	NNP
cord-003921-8r8z0otz	51	3	.	.	.
cord-003921-8r8z0otz	51	4	1a	1a	CD
cord-003921-8r8z0otz	51	5	)	)	-RRB-
cord-003921-8r8z0otz	51	6	.	.	.
cord-003921-8r8z0otz	52	1	Because	because	IN
cord-003921-8r8z0otz	52	2	of	of	IN
cord-003921-8r8z0otz	52	3	the	the	DT
cord-003921-8r8z0otz	52	4	unusual	unusual	JJ
cord-003921-8r8z0otz	52	5	hepatic	hepatic	JJ
cord-003921-8r8z0otz	52	6	microvasculature	microvasculature	NN
cord-003921-8r8z0otz	52	7	,	,	,
cord-003921-8r8z0otz	52	8	circulating	circulate	VBG
cord-003921-8r8z0otz	52	9	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	52	10	can	can	MD
cord-003921-8r8z0otz	52	11	move	move	VB
cord-003921-8r8z0otz	52	12	directly	directly	RB
cord-003921-8r8z0otz	52	13	to	to	IN
cord-003921-8r8z0otz	52	14	integrinmediated	integrinmediate	VBN
cord-003921-8r8z0otz	52	15	adhesion	adhesion	NN
cord-003921-8r8z0otz	52	16	devoid	devoid	JJ
cord-003921-8r8z0otz	52	17	of	of	IN
cord-003921-8r8z0otz	52	18	selectin	selectin	NN
cord-003921-8r8z0otz	52	19	-	-	HYPH
cord-003921-8r8z0otz	52	20	mediated	mediate	VBN
cord-003921-8r8z0otz	52	21	rolling	rolling	NN
cord-003921-8r8z0otz	52	22	.	.	.
cord-003921-8r8z0otz	53	1	In	in	IN
cord-003921-8r8z0otz	53	2	line	line	NN
cord-003921-8r8z0otz	53	3	with	with	IN
cord-003921-8r8z0otz	53	4	this	this	DT
cord-003921-8r8z0otz	53	5	scenario	scenario	NN
cord-003921-8r8z0otz	53	6	,	,	,
cord-003921-8r8z0otz	53	7	Mac-1	Mac-1	NNP
cord-003921-8r8z0otz	53	8	or	or	CC
cord-003921-8r8z0otz	53	9	ICAM-1	ICAM-1	NNP
cord-003921-8r8z0otz	53	10	neutralizing	neutralize	VBG
cord-003921-8r8z0otz	53	11	antibodies	antibody	NNS
cord-003921-8r8z0otz	53	12	effectively	effectively	RB
cord-003921-8r8z0otz	53	13	alleviated	alleviate	VBD
cord-003921-8r8z0otz	53	14	liver	liver	NN
cord-003921-8r8z0otz	53	15	IRI	IRI	NNP
cord-003921-8r8z0otz	53	16	[	[	-LRB-
cord-003921-8r8z0otz	53	17	23	23	CD
cord-003921-8r8z0otz	53	18	,	,	,
cord-003921-8r8z0otz	53	19	24	24	CD
cord-003921-8r8z0otz	53	20	]	]	-RRB-
cord-003921-8r8z0otz	53	21	.	.	.
cord-003921-8r8z0otz	54	1	Histone	Histone	NNP
cord-003921-8r8z0otz	54	2	and	and	CC
cord-003921-8r8z0otz	54	3	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	54	4	are	be	VBP
cord-003921-8r8z0otz	54	5	among	among	IN
cord-003921-8r8z0otz	54	6	the	the	DT
cord-003921-8r8z0otz	54	7	most	most	RBS
cord-003921-8r8z0otz	54	8	tested	test	VBN
cord-003921-8r8z0otz	54	9	DAMPs	damp	NNS
cord-003921-8r8z0otz	54	10	in	in	IN
cord-003921-8r8z0otz	54	11	the	the	DT
cord-003921-8r8z0otz	54	12	model	model	NN
cord-003921-8r8z0otz	54	13	of	of	IN
cord-003921-8r8z0otz	54	14	liver	liver	NN
cord-003921-8r8z0otz	54	15	IRI	IRI	NNP
cord-003921-8r8z0otz	54	16	.	.	.
cord-003921-8r8z0otz	55	1	The	the	DT
cord-003921-8r8z0otz	55	2	levels	level	NNS
cord-003921-8r8z0otz	55	3	of	of	IN
cord-003921-8r8z0otz	55	4	circulating	circulate	VBG
cord-003921-8r8z0otz	55	5	histones	histone	NNS
cord-003921-8r8z0otz	55	6	are	be	VBP
cord-003921-8r8z0otz	55	7	significantly	significantly	RB
cord-003921-8r8z0otz	55	8	increased	increase	VBN
cord-003921-8r8z0otz	55	9	in	in	IN
cord-003921-8r8z0otz	55	10	liver	liver	NN
cord-003921-8r8z0otz	55	11	IRI	IRI	NNP
cord-003921-8r8z0otz	55	12	,	,	,
cord-003921-8r8z0otz	55	13	and	and	CC
cord-003921-8r8z0otz	55	14	anti	anti	JJ
cord-003921-8r8z0otz	55	15	-	-	JJ
cord-003921-8r8z0otz	55	16	histone	histone	JJ
cord-003921-8r8z0otz	55	17	neutralizing	neutralize	VBG
cord-003921-8r8z0otz	55	18	antibodies	antibody	NNS
cord-003921-8r8z0otz	55	19	suppress	suppress	VBP
cord-003921-8r8z0otz	55	20	TLR9	TLR9	NNP
cord-003921-8r8z0otz	55	21	/	/	SYM
cord-003921-8r8z0otz	55	22	MyD88	MyD88	NNS
cord-003921-8r8z0otz	55	23	signaling	signal	VBG
cord-003921-8r8z0otz	55	24	while	while	IN
cord-003921-8r8z0otz	55	25	decreasing	decrease	VBG
cord-003921-8r8z0otz	55	26	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	55	27	hepatic	hepatic	JJ
cord-003921-8r8z0otz	55	28	damage	damage	NN
cord-003921-8r8z0otz	55	29	[	[	-LRB-
cord-003921-8r8z0otz	55	30	25	25	CD
cord-003921-8r8z0otz	55	31	]	]	-RRB-
cord-003921-8r8z0otz	55	32	.	.	.
cord-003921-8r8z0otz	56	1	Treatment	treatment	NN
cord-003921-8r8z0otz	56	2	with	with	IN
cord-003921-8r8z0otz	56	3	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	56	4	neutralizing	neutralize	VBG
cord-003921-8r8z0otz	56	5	antibody	antibody	NN
cord-003921-8r8z0otz	56	6	alleviated	alleviate	VBD
cord-003921-8r8z0otz	56	7	IRI	IRI	NNP
cord-003921-8r8z0otz	56	8	in	in	IN
cord-003921-8r8z0otz	56	9	WT	WT	NNP
cord-003921-8r8z0otz	56	10	but	but	CC
cord-003921-8r8z0otz	56	11	not	not	RB
cord-003921-8r8z0otz	56	12	TLR4deficient	TLR4deficient	NNP
cord-003921-8r8z0otz	56	13	mouse	mouse	NN
cord-003921-8r8z0otz	56	14	recipients	recipient	NNS
cord-003921-8r8z0otz	56	15	[	[	-LRB-
cord-003921-8r8z0otz	56	16	26	26	CD
cord-003921-8r8z0otz	56	17	]	]	-RRB-
cord-003921-8r8z0otz	56	18	.	.	.
cord-003921-8r8z0otz	57	1	Likewise	likewise	RB
cord-003921-8r8z0otz	57	2	,	,	,
cord-003921-8r8z0otz	57	3	recombinant	recombinant	JJ
cord-003921-8r8z0otz	57	4	thrombomodulin	thrombomodulin	NNP
cord-003921-8r8z0otz	57	5	(	(	-LRB-
cord-003921-8r8z0otz	57	6	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	57	7	inactivator	inactivator	NNP
cord-003921-8r8z0otz	57	8	)	)	-RRB-
cord-003921-8r8z0otz	57	9	mitigated	mitigate	VBD
cord-003921-8r8z0otz	57	10	liver	liver	NN
cord-003921-8r8z0otz	57	11	IRI	IRI	NNP
cord-003921-8r8z0otz	57	12	in	in	IN
cord-003921-8r8z0otz	57	13	WT	WT	NNP
cord-003921-8r8z0otz	57	14	but	but	CC
cord-003921-8r8z0otz	57	15	not	not	RB
cord-003921-8r8z0otz	57	16	TLR4-knockout	tlr4-knockout	IN
cord-003921-8r8z0otz	57	17	mouse	mouse	NN
cord-003921-8r8z0otz	57	18	[	[	-LRB-
cord-003921-8r8z0otz	57	19	27•	27•	CD
cord-003921-8r8z0otz	57	20	]	]	-RRB-
cord-003921-8r8z0otz	57	21	.	.	.
cord-003921-8r8z0otz	58	1	Since	since	IN
cord-003921-8r8z0otz	58	2	broad	broad	JJ
cord-003921-8r8z0otz	58	3	spectrum	spectrum	NN
cord-003921-8r8z0otz	58	4	of	of	IN
cord-003921-8r8z0otz	58	5	immune	immune	JJ
cord-003921-8r8z0otz	58	6	cells	cell	NNS
cord-003921-8r8z0otz	58	7	express	express	VBP
cord-003921-8r8z0otz	58	8	TLRs	TLRs	NNP
cord-003921-8r8z0otz	58	9	,	,	,
cord-003921-8r8z0otz	58	10	the	the	DT
cord-003921-8r8z0otz	58	11	HMGB1-TLR4	HMGB1-TLR4	NNP
cord-003921-8r8z0otz	58	12	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	58	13	axis	axis	NN
cord-003921-8r8z0otz	58	14	is	be	VBZ
cord-003921-8r8z0otz	58	15	unlikely	unlikely	JJ
cord-003921-8r8z0otz	58	16	to	to	TO
cord-003921-8r8z0otz	58	17	be	be	VB
cord-003921-8r8z0otz	58	18	exclusive	exclusive	JJ
cord-003921-8r8z0otz	58	19	for	for	IN
cord-003921-8r8z0otz	58	20	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	58	21	regulation	regulation	NN
cord-003921-8r8z0otz	58	22	.	.	.
cord-003921-8r8z0otz	59	1	Indeed	indeed	RB
cord-003921-8r8z0otz	59	2	,	,	,
cord-003921-8r8z0otz	59	3	hepatocyte	hepatocyte	NN
cord-003921-8r8z0otz	59	4	-	-	HYPH
cord-003921-8r8z0otz	59	5	specific	specific	JJ
cord-003921-8r8z0otz	59	6	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	59	7	deficient	deficient	JJ
cord-003921-8r8z0otz	59	8	mice	mouse	NNS
cord-003921-8r8z0otz	59	9	showed	show	VBD
cord-003921-8r8z0otz	59	10	decreased	decrease	VBN
cord-003921-8r8z0otz	59	11	hepatic	hepatic	JJ
cord-003921-8r8z0otz	59	12	necrosis	necrosis	NN
cord-003921-8r8z0otz	59	13	and	and	CC
cord-003921-8r8z0otz	59	14	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	59	15	accumulation	accumulation	NN
cord-003921-8r8z0otz	59	16	,	,	,
cord-003921-8r8z0otz	59	17	whereas	whereas	IN
cord-003921-8r8z0otz	59	18	the	the	DT
cord-003921-8r8z0otz	59	19	number	number	NN
cord-003921-8r8z0otz	59	20	of	of	IN
cord-003921-8r8z0otz	59	21	their	-PRON-	PRP$
cord-003921-8r8z0otz	59	22	macrophages	macrophage	NNS
cord-003921-8r8z0otz	59	23	remained	remain	VBD
cord-003921-8r8z0otz	59	24	unchanged	unchanged	JJ
cord-003921-8r8z0otz	59	25	in	in	IN
cord-003921-8r8z0otz	59	26	acetaminophen	acetaminophen	NN
cord-003921-8r8z0otz	59	27	-	-	HYPH
cord-003921-8r8z0otz	59	28	induced	induce	VBN
cord-003921-8r8z0otz	59	29	liver	liver	NN
cord-003921-8r8z0otz	59	30	injury	injury	NN
cord-003921-8r8z0otz	59	31	model	model	NN
cord-003921-8r8z0otz	59	32	[	[	-LRB-
cord-003921-8r8z0otz	59	33	28	28	CD
cord-003921-8r8z0otz	59	34	]	]	-RRB-
cord-003921-8r8z0otz	59	35	.	.	.
cord-003921-8r8z0otz	60	1	In	in	IN
cord-003921-8r8z0otz	60	2	contrast	contrast	NN
cord-003921-8r8z0otz	60	3	,	,	,
cord-003921-8r8z0otz	60	4	hepatocyte	hepatocyte	NN
cord-003921-8r8z0otz	60	5	-	-	HYPH
cord-003921-8r8z0otz	60	6	specific	specific	JJ
cord-003921-8r8z0otz	60	7	HMGB1-deficient	HMGB1-deficient	NNP
cord-003921-8r8z0otz	60	8	mice	mouse	NNS
cord-003921-8r8z0otz	60	9	exhibited	exhibit	VBD
cord-003921-8r8z0otz	60	10	exaggerated	exaggerated	JJ
cord-003921-8r8z0otz	60	11	liver	liver	NN
cord-003921-8r8z0otz	60	12	IR	IR	NNP
cord-003921-8r8z0otz	60	13	-	-	HYPH
cord-003921-8r8z0otz	60	14	damage	damage	NN
cord-003921-8r8z0otz	60	15	,	,	,
cord-003921-8r8z0otz	60	16	implying	imply	VBG
cord-003921-8r8z0otz	60	17	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	60	18	is	be	VBZ
cord-003921-8r8z0otz	60	19	essential	essential	JJ
cord-003921-8r8z0otz	60	20	for	for	IN
cord-003921-8r8z0otz	60	21	hepatocyte	hepatocyte	NN
cord-003921-8r8z0otz	60	22	resistance	resistance	NN
cord-003921-8r8z0otz	60	23	against	against	IN
cord-003921-8r8z0otz	60	24	hypoxia	hypoxia	NN
cord-003921-8r8z0otz	60	25	[	[	-LRB-
cord-003921-8r8z0otz	60	26	29	29	CD
cord-003921-8r8z0otz	60	27	]	]	-RRB-
cord-003921-8r8z0otz	60	28	.	.	.
cord-003921-8r8z0otz	61	1	Clearly	clearly	RB
cord-003921-8r8z0otz	61	2	,	,	,
cord-003921-8r8z0otz	61	3	extracellular	extracellular	JJ
cord-003921-8r8z0otz	61	4	DAMPs	damp	NNS
cord-003921-8r8z0otz	61	5	are	be	VBP
cord-003921-8r8z0otz	61	6	promising	promise	VBG
cord-003921-8r8z0otz	61	7	therapeutic	therapeutic	JJ
cord-003921-8r8z0otz	61	8	targets	target	NNS
cord-003921-8r8z0otz	61	9	to	to	TO
cord-003921-8r8z0otz	61	10	manage	manage	VB
cord-003921-8r8z0otz	61	11	liver	liver	NN
cord-003921-8r8z0otz	61	12	IRI	IRI	NNP
cord-003921-8r8z0otz	61	13	by	by	IN
cord-003921-8r8z0otz	61	14	alleviating	alleviate	VBG
cord-003921-8r8z0otz	61	15	innate	innate	JJ
cord-003921-8r8z0otz	61	16	,	,	,
cord-003921-8r8z0otz	61	17	including	include	VBG
cord-003921-8r8z0otz	61	18	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	61	19	,	,	,
cord-003921-8r8z0otz	61	20	cell	cell	NN
cord-003921-8r8z0otz	61	21	responses	response	NNS
cord-003921-8r8z0otz	61	22	.	.	.
cord-003921-8r8z0otz	62	1	Following	follow	VBG
cord-003921-8r8z0otz	62	2	adhesion	adhesion	NN
cord-003921-8r8z0otz	62	3	to	to	IN
cord-003921-8r8z0otz	62	4	the	the	DT
cord-003921-8r8z0otz	62	5	endothelium	endothelium	NN
cord-003921-8r8z0otz	62	6	,	,	,
cord-003921-8r8z0otz	62	7	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	62	8	are	be	VBP
cord-003921-8r8z0otz	62	9	guided	guide	VBN
cord-003921-8r8z0otz	62	10	by	by	IN
cord-003921-8r8z0otz	62	11	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	62	12	cell	cell	NN
cord-003921-8r8z0otz	62	13	-	-	HYPH
cord-003921-8r8z0otz	62	14	derived	derive	VBN
cord-003921-8r8z0otz	62	15	chemokines	chemokine	NNS
cord-003921-8r8z0otz	62	16	(	(	-LRB-
cord-003921-8r8z0otz	62	17	CXCL1	CXCL1	NNP
cord-003921-8r8z0otz	62	18	,	,	,
cord-003921-8r8z0otz	62	19	CXCL2	cxcl2	NN
cord-003921-8r8z0otz	62	20	)	)	-RRB-
cord-003921-8r8z0otz	62	21	,	,	,
cord-003921-8r8z0otz	62	22	bind	bind	VB
cord-003921-8r8z0otz	62	23	to	to	IN
cord-003921-8r8z0otz	62	24	CXCR2	CXCR2	NNS
cord-003921-8r8z0otz	62	25	on	on	IN
cord-003921-8r8z0otz	62	26	the	the	DT
cord-003921-8r8z0otz	62	27	luminal	luminal	JJ
cord-003921-8r8z0otz	62	28	surface	surface	NN
cord-003921-8r8z0otz	62	29	of	of	IN
cord-003921-8r8z0otz	62	30	LSECs	lsec	NNS
cord-003921-8r8z0otz	62	31	,	,	,
cord-003921-8r8z0otz	62	32	and	and	CC
cord-003921-8r8z0otz	62	33	form	form	VB
cord-003921-8r8z0otz	62	34	the	the	DT
cord-003921-8r8z0otz	62	35	chemotactic	chemotactic	JJ
cord-003921-8r8z0otz	62	36	gradient	gradient	NN
cord-003921-8r8z0otz	62	37	at	at	IN
cord-003921-8r8z0otz	62	38	the	the	DT
cord-003921-8r8z0otz	62	39	injury	injury	NN
cord-003921-8r8z0otz	62	40	site	site	NN
cord-003921-8r8z0otz	62	41	[	[	-LRB-
cord-003921-8r8z0otz	62	42	20	20	CD
cord-003921-8r8z0otz	62	43	]	]	-RRB-
cord-003921-8r8z0otz	62	44	(	(	-LRB-
cord-003921-8r8z0otz	62	45	Fig	fig	NN
cord-003921-8r8z0otz	62	46	.	.	.
cord-003921-8r8z0otz	62	47	1b	1b	CD
cord-003921-8r8z0otz	62	48	)	)	-RRB-
cord-003921-8r8z0otz	62	49	.	.	.
cord-003921-8r8z0otz	63	1	Consistent	consistent	JJ
cord-003921-8r8z0otz	63	2	with	with	IN
cord-003921-8r8z0otz	63	3	such	such	PDT
cord-003921-8r8z0otz	63	4	a	a	DT
cord-003921-8r8z0otz	63	5	mechanism	mechanism	NN
cord-003921-8r8z0otz	63	6	,	,	,
cord-003921-8r8z0otz	63	7	reparixin	reparixin	NNP
cord-003921-8r8z0otz	63	8	(	(	-LRB-
cord-003921-8r8z0otz	63	9	an	an	DT
cord-003921-8r8z0otz	63	10	allosteric	allosteric	JJ
cord-003921-8r8z0otz	63	11	CXCR2	CXCR2	NNS
cord-003921-8r8z0otz	63	12	antagonist	antagonist	NN
cord-003921-8r8z0otz	63	13	)	)	-RRB-
cord-003921-8r8z0otz	63	14	decreased	decrease	VBD
cord-003921-8r8z0otz	63	15	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	63	16	infiltration	infiltration	NN
cord-003921-8r8z0otz	63	17	and	and	CC
cord-003921-8r8z0otz	63	18	mitigated	mitigate	VBD
cord-003921-8r8z0otz	63	19	liver	liver	NN
cord-003921-8r8z0otz	63	20	IRI	IRI	NNP
cord-003921-8r8z0otz	63	21	[	[	-LRB-
cord-003921-8r8z0otz	63	22	30	30	CD
cord-003921-8r8z0otz	63	23	]	]	-RRB-
cord-003921-8r8z0otz	63	24	.	.	.
cord-003921-8r8z0otz	64	1	In	in	IN
cord-003921-8r8z0otz	64	2	addition	addition	NN
cord-003921-8r8z0otz	64	3	,	,	,
cord-003921-8r8z0otz	64	4	CXCL1	CXCL1	NNP
cord-003921-8r8z0otz	64	5	blocking	block	VBG
cord-003921-8r8z0otz	64	6	antibody	antibody	NN
cord-003921-8r8z0otz	64	7	alleviated	alleviate	VBD
cord-003921-8r8z0otz	64	8	hepatic	hepatic	JJ
cord-003921-8r8z0otz	64	9	infiltration	infiltration	NN
cord-003921-8r8z0otz	64	10	in	in	IN
cord-003921-8r8z0otz	64	11	necrotic	necrotic	JJ
cord-003921-8r8z0otz	64	12	cellinduced	cellinduced	JJ
cord-003921-8r8z0otz	64	13	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	64	14	mobilization	mobilization	NN
cord-003921-8r8z0otz	64	15	model	model	NN
cord-003921-8r8z0otz	64	16	[	[	-LRB-
cord-003921-8r8z0otz	64	17	31	31	CD
cord-003921-8r8z0otz	64	18	]	]	-RRB-
cord-003921-8r8z0otz	64	19	,	,	,
cord-003921-8r8z0otz	64	20	whereas	whereas	IN
cord-003921-8r8z0otz	64	21	in	in	IN
cord-003921-8r8z0otz	64	22	a	a	DT
cord-003921-8r8z0otz	64	23	carbon	carbon	NN
cord-003921-8r8z0otz	64	24	tetrachloride	tetrachloride	NN
cord-003921-8r8z0otz	64	25	(	(	-LRB-
cord-003921-8r8z0otz	64	26	CCl4)-induced	ccl4)-induced	JJ
cord-003921-8r8z0otz	64	27	acute	acute	JJ
cord-003921-8r8z0otz	64	28	liver	liver	NN
cord-003921-8r8z0otz	64	29	injury	injury	NN
cord-003921-8r8z0otz	64	30	,	,	,
cord-003921-8r8z0otz	64	31	defective	defective	JJ
cord-003921-8r8z0otz	64	32	CXCL2	cxcl2	NN
cord-003921-8r8z0otz	64	33	expression	expression	NN
cord-003921-8r8z0otz	64	34	in	in	IN
cord-003921-8r8z0otz	64	35	TLR2-knockout	tlr2-knockout	NN
cord-003921-8r8z0otz	64	36	or	or	CC
cord-003921-8r8z0otz	64	37	S100A9-knockout	S100A9-knockout	NNP
cord-003921-8r8z0otz	64	38	mice	mouse	NNS
cord-003921-8r8z0otz	64	39	was	be	VBD
cord-003921-8r8z0otz	64	40	accompanied	accompany	VBN
cord-003921-8r8z0otz	64	41	by	by	IN
cord-003921-8r8z0otz	64	42	suppressed	suppress	VBN
cord-003921-8r8z0otz	64	43	hepatic	hepatic	JJ
cord-003921-8r8z0otz	64	44	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	64	45	recruitment	recruitment	NN
cord-003921-8r8z0otz	64	46	[	[	-LRB-
cord-003921-8r8z0otz	64	47	32	32	CD
cord-003921-8r8z0otz	64	48	]	]	-RRB-
cord-003921-8r8z0otz	64	49	.	.	.
cord-003921-8r8z0otz	65	1	In	in	IN
cord-003921-8r8z0otz	65	2	the	the	DT
cord-003921-8r8z0otz	65	3	following	follow	VBG
cord-003921-8r8z0otz	65	4	dynamic	dynamic	JJ
cord-003921-8r8z0otz	65	5	stage	stage	NN
cord-003921-8r8z0otz	65	6	,	,	,
cord-003921-8r8z0otz	65	7	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	65	8	moving	move	VBG
cord-003921-8r8z0otz	65	9	on	on	IN
cord-003921-8r8z0otz	65	10	the	the	DT
cord-003921-8r8z0otz	65	11	LSECs	lsec	NNS
cord-003921-8r8z0otz	65	12	luminal	luminal	JJ
cord-003921-8r8z0otz	65	13	side	side	NN
cord-003921-8r8z0otz	65	14	migrate	migrate	VBP
cord-003921-8r8z0otz	65	15	underneath	underneath	IN
cord-003921-8r8z0otz	65	16	the	the	DT
cord-003921-8r8z0otz	65	17	sinusoidal	sinusoidal	JJ
cord-003921-8r8z0otz	65	18	wall	wall	NN
cord-003921-8r8z0otz	65	19	to	to	IN
cord-003921-8r8z0otz	65	20	the	the	DT
cord-003921-8r8z0otz	65	21	damaged	damage	VBN
cord-003921-8r8z0otz	65	22	site	site	NN
cord-003921-8r8z0otz	65	23	.	.	.
cord-003921-8r8z0otz	66	1	Mitochondrial	Mitochondrial	NNP
cord-003921-8r8z0otz	66	2	N	N	NNP
cord-003921-8r8z0otz	66	3	-	-	HYPH
cord-003921-8r8z0otz	66	4	formyl	formyl	NNP
cord-003921-8r8z0otz	66	5	peptides	peptide	NNS
cord-003921-8r8z0otz	66	6	(	(	-LRB-
cord-003921-8r8z0otz	66	7	FMIT	FMIT	NNP
cord-003921-8r8z0otz	66	8	)	)	-RRB-
cord-003921-8r8z0otz	66	9	,	,	,
cord-003921-8r8z0otz	66	10	cleavage	cleavage	NN
cord-003921-8r8z0otz	66	11	products	product	NNS
cord-003921-8r8z0otz	66	12	of	of	IN
cord-003921-8r8z0otz	66	13	mitochondrial	mitochondrial	JJ
cord-003921-8r8z0otz	66	14	proteins	protein	NNS
cord-003921-8r8z0otz	66	15	,	,	,
cord-003921-8r8z0otz	66	16	are	be	VBP
cord-003921-8r8z0otz	66	17	critically	critically	RB
cord-003921-8r8z0otz	66	18	involved	involved	JJ
cord-003921-8r8z0otz	66	19	in	in	IN
cord-003921-8r8z0otz	66	20	this	this	DT
cord-003921-8r8z0otz	66	21	process	process	NN
cord-003921-8r8z0otz	66	22	serving	serve	VBG
cord-003921-8r8z0otz	66	23	as	as	IN
cord-003921-8r8z0otz	66	24	chemoattractant	chemoattractant	NN
cord-003921-8r8z0otz	66	25	DAMPs	damp	NNS
cord-003921-8r8z0otz	66	26	.	.	.
cord-003921-8r8z0otz	67	1	Damaged	damaged	JJ
cord-003921-8r8z0otz	67	2	cells	cell	NNS
cord-003921-8r8z0otz	67	3	release	release	VBP
cord-003921-8r8z0otz	67	4	FMIT	FMIT	NNP
cord-003921-8r8z0otz	67	5	and	and	CC
cord-003921-8r8z0otz	67	6	create	create	VB
cord-003921-8r8z0otz	67	7	a	a	DT
cord-003921-8r8z0otz	67	8	gradient	gradient	NN
cord-003921-8r8z0otz	67	9	that	that	WDT
cord-003921-8r8z0otz	67	10	attracts	attract	VBZ
cord-003921-8r8z0otz	67	11	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	67	12	through	through	IN
cord-003921-8r8z0otz	67	13	neutrophilspecific	neutrophilspecific	NNP
cord-003921-8r8z0otz	67	14	formyl	formyl	NNP
cord-003921-8r8z0otz	67	15	peptide	peptide	NN
cord-003921-8r8z0otz	67	16	receptor	receptor	NN
cord-003921-8r8z0otz	67	17	1	1	CD
cord-003921-8r8z0otz	67	18	(	(	-LRB-
cord-003921-8r8z0otz	67	19	FPR1	FPR1	NNP
cord-003921-8r8z0otz	67	20	)	)	-RRB-
cord-003921-8r8z0otz	68	1	[	[	-LRB-
cord-003921-8r8z0otz	68	2	33	33	CD
cord-003921-8r8z0otz	68	3	]	]	-RRB-
cord-003921-8r8z0otz	68	4	.	.	.
cord-003921-8r8z0otz	69	1	Honda	Honda	NNP
cord-003921-8r8z0otz	69	2	Neutrophils	Neutrophils	NNP
cord-003921-8r8z0otz	69	3	move	move	VBP
cord-003921-8r8z0otz	69	4	on	on	IN
cord-003921-8r8z0otz	69	5	the	the	DT
cord-003921-8r8z0otz	69	6	LSECs	lsec	NNS
cord-003921-8r8z0otz	69	7	luminal	luminal	JJ
cord-003921-8r8z0otz	69	8	side	side	NN
cord-003921-8r8z0otz	69	9	toward	toward	IN
cord-003921-8r8z0otz	69	10	the	the	DT
cord-003921-8r8z0otz	69	11	damaged	damage	VBN
cord-003921-8r8z0otz	69	12	site	site	NN
cord-003921-8r8z0otz	69	13	,	,	,
cord-003921-8r8z0otz	69	14	guided	guide	VBN
cord-003921-8r8z0otz	69	15	by	by	IN
cord-003921-8r8z0otz	69	16	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	69	17	cell	cell	NN
cord-003921-8r8z0otz	69	18	-	-	HYPH
cord-003921-8r8z0otz	69	19	derived	derive	VBN
cord-003921-8r8z0otz	69	20	chemokine	chemokine	NN
cord-003921-8r8z0otz	69	21	(	(	-LRB-
cord-003921-8r8z0otz	69	22	CXCL1	cxcl1	NN
cord-003921-8r8z0otz	69	23	/	/	SYM
cord-003921-8r8z0otz	69	24	CXCL2	cxcl2	NN
cord-003921-8r8z0otz	69	25	)	)	-RRB-
cord-003921-8r8z0otz	69	26	gradient	gradient	NN
cord-003921-8r8z0otz	69	27	.	.	.
cord-003921-8r8z0otz	70	1	c	c	LS
cord-003921-8r8z0otz	70	2	Neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	70	3	detect	detect	VBP
cord-003921-8r8z0otz	70	4	mitochondrial	mitochondrial	JJ
cord-003921-8r8z0otz	70	5	N	N	NNP
cord-003921-8r8z0otz	70	6	-	-	HYPH
cord-003921-8r8z0otz	70	7	formyl	formyl	NNP
cord-003921-8r8z0otz	70	8	peptides	peptide	NNS
cord-003921-8r8z0otz	70	9	(	(	-LRB-
cord-003921-8r8z0otz	70	10	FMIT	FMIT	NNP
cord-003921-8r8z0otz	70	11	)	)	-RRB-
cord-003921-8r8z0otz	70	12	via	via	IN
cord-003921-8r8z0otz	70	13	formyl	formyl	NNP
cord-003921-8r8z0otz	70	14	peptide	peptide	NN
cord-003921-8r8z0otz	70	15	receptor	receptor	NN
cord-003921-8r8z0otz	70	16	1	1	CD
cord-003921-8r8z0otz	70	17	(	(	-LRB-
cord-003921-8r8z0otz	70	18	FPR1	FPR1	NNP
cord-003921-8r8z0otz	70	19	)	)	-RRB-
cord-003921-8r8z0otz	70	20	and	and	CC
cord-003921-8r8z0otz	70	21	migrate	migrate	VB
cord-003921-8r8z0otz	70	22	underneath	underneath	IN
cord-003921-8r8z0otz	70	23	LSECs	lsec	NNS
cord-003921-8r8z0otz	70	24	toward	toward	IN
cord-003921-8r8z0otz	70	25	the	the	DT
cord-003921-8r8z0otz	70	26	injury	injury	NN
cord-003921-8r8z0otz	70	27	site	site	NN
cord-003921-8r8z0otz	70	28	.	.	.
cord-003921-8r8z0otz	71	1	d	d	NNP
cord-003921-8r8z0otz	71	2	Neutrophils	Neutrophils	NNP
cord-003921-8r8z0otz	71	3	express	express	VBP
cord-003921-8r8z0otz	71	4	and	and	CC
cord-003921-8r8z0otz	71	5	secret	secret	JJ
cord-003921-8r8z0otz	71	6	matrix	matrix	NN
cord-003921-8r8z0otz	71	7	metalloproteinase	metalloproteinase	NN
cord-003921-8r8z0otz	71	8	9	9	CD
cord-003921-8r8z0otz	71	9	(	(	-LRB-
cord-003921-8r8z0otz	71	10	MMP9	MMP9	NNP
cord-003921-8r8z0otz	71	11	)	)	-RRB-
cord-003921-8r8z0otz	71	12	to	to	TO
cord-003921-8r8z0otz	71	13	degrade	degrade	VB
cord-003921-8r8z0otz	71	14	extracellular	extracellular	JJ
cord-003921-8r8z0otz	71	15	matrix	matrix	NN
cord-003921-8r8z0otz	71	16	(	(	-LRB-
cord-003921-8r8z0otz	71	17	ECM	ECM	NNP
cord-003921-8r8z0otz	71	18	)	)	-RRB-
cord-003921-8r8z0otz	71	19	during	during	IN
cord-003921-8r8z0otz	71	20	migration	migration	NN
cord-003921-8r8z0otz	71	21	reported	report	VBD
cord-003921-8r8z0otz	71	22	that	that	IN
cord-003921-8r8z0otz	71	23	cyclosporine	cyclosporine	NN
cord-003921-8r8z0otz	71	24	H	h	NN
cord-003921-8r8z0otz	71	25	(	(	-LRB-
cord-003921-8r8z0otz	71	26	FPR1	FPR1	NNP
cord-003921-8r8z0otz	71	27	antagonist	antagonist	NN
cord-003921-8r8z0otz	71	28	)	)	-RRB-
cord-003921-8r8z0otz	71	29	decreased	decrease	VBD
cord-003921-8r8z0otz	71	30	the	the	DT
cord-003921-8r8z0otz	71	31	number	number	NN
cord-003921-8r8z0otz	71	32	and	and	CC
cord-003921-8r8z0otz	71	33	crawling	crawl	VBG
cord-003921-8r8z0otz	71	34	velocity	velocity	NN
cord-003921-8r8z0otz	71	35	of	of	IN
cord-003921-8r8z0otz	71	36	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	71	37	while	while	IN
cord-003921-8r8z0otz	71	38	alleviating	alleviate	VBG
cord-003921-8r8z0otz	71	39	liver	liver	NN
cord-003921-8r8z0otz	71	40	IRI	IRI	NNP
cord-003921-8r8z0otz	71	41	and	and	CC
cord-003921-8r8z0otz	71	42	inhibiting	inhibit	VBG
cord-003921-8r8z0otz	71	43	the	the	DT
cord-003921-8r8z0otz	71	44	accumulation	accumulation	NN
cord-003921-8r8z0otz	71	45	of	of	IN
cord-003921-8r8z0otz	71	46	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	71	47	into	into	IN
cord-003921-8r8z0otz	71	48	laser	laser	NN
cord-003921-8r8z0otz	71	49	irradiation	irradiation	NN
cord-003921-8r8z0otz	71	50	-	-	HYPH
cord-003921-8r8z0otz	71	51	induced	induce	VBN
cord-003921-8r8z0otz	71	52	necrotic	necrotic	JJ
cord-003921-8r8z0otz	71	53	areas	area	NNS
cord-003921-8r8z0otz	71	54	[	[	-LRB-
cord-003921-8r8z0otz	71	55	34•	34•	CD
cord-003921-8r8z0otz	71	56	]	]	-RRB-
cord-003921-8r8z0otz	71	57	.	.	.
cord-003921-8r8z0otz	72	1	Interestingly	interestingly	RB
cord-003921-8r8z0otz	72	2	,	,	,
cord-003921-8r8z0otz	72	3	at	at	IN
cord-003921-8r8z0otz	72	4	this	this	DT
cord-003921-8r8z0otz	72	5	time	time	NN
cord-003921-8r8z0otz	72	6	point	point	NN
cord-003921-8r8z0otz	72	7	,	,	,
cord-003921-8r8z0otz	72	8	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	72	9	are	be	VBP
cord-003921-8r8z0otz	72	10	attracted	attract	VBN
cord-003921-8r8z0otz	72	11	by	by	IN
cord-003921-8r8z0otz	72	12	two	two	CD
cord-003921-8r8z0otz	72	13	opposing	oppose	VBG
cord-003921-8r8z0otz	72	14	chemoattractant	chemoattractant	NN
cord-003921-8r8z0otz	72	15	gradients	gradient	NNS
cord-003921-8r8z0otz	72	16	,	,	,
cord-003921-8r8z0otz	72	17	CXCL2	CXCL2	VBD
cord-003921-8r8z0otz	72	18	mostly	mostly	RB
cord-003921-8r8z0otz	72	19	anchored	anchor	VBN
cord-003921-8r8z0otz	72	20	on	on	IN
cord-003921-8r8z0otz	72	21	the	the	DT
cord-003921-8r8z0otz	72	22	luminal	luminal	JJ
cord-003921-8r8z0otz	72	23	LSECs	lsec	NNS
cord-003921-8r8z0otz	72	24	side	side	NN
cord-003921-8r8z0otz	72	25	and	and	CC
cord-003921-8r8z0otz	72	26	FMIT	FMIT	NNP
cord-003921-8r8z0otz	72	27	emanated	emanate	VBD
cord-003921-8r8z0otz	72	28	from	from	IN
cord-003921-8r8z0otz	72	29	parenchymal	parenchymal	NN
cord-003921-8r8z0otz	72	30	damaged	damage	VBN
cord-003921-8r8z0otz	72	31	cells	cell	NNS
cord-003921-8r8z0otz	72	32	.	.	.
cord-003921-8r8z0otz	73	1	The	the	DT
cord-003921-8r8z0otz	73	2	final	final	JJ
cord-003921-8r8z0otz	73	3	signaling	signaling	NN
cord-003921-8r8z0otz	73	4	via	via	IN
cord-003921-8r8z0otz	73	5	FMIT	FMIT	NNP
cord-003921-8r8z0otz	73	6	-	-	HYPH
cord-003921-8r8z0otz	73	7	FPR1	FPR1	NNP
cord-003921-8r8z0otz	73	8	overrides	override	VBZ
cord-003921-8r8z0otz	73	9	the	the	DT
cord-003921-8r8z0otz	73	10	CXCL1	CXCL1	NNP
cord-003921-8r8z0otz	73	11	/	/	SYM
cord-003921-8r8z0otz	73	12	CXCL2-CXCR2	CXCL2-CXCR2	NNP
cord-003921-8r8z0otz	73	13	axis	axis	NN
cord-003921-8r8z0otz	73	14	,	,	,
cord-003921-8r8z0otz	73	15	making	make	VBG
cord-003921-8r8z0otz	73	16	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	73	17	to	to	TO
cord-003921-8r8z0otz	73	18	preferentially	preferentially	RB
cord-003921-8r8z0otz	73	19	migrate	migrate	VB
cord-003921-8r8z0otz	73	20	toward	toward	IN
cord-003921-8r8z0otz	73	21	the	the	DT
cord-003921-8r8z0otz	73	22	FMIT	FMIT	NNP
cord-003921-8r8z0otz	73	23	while	while	IN
cord-003921-8r8z0otz	73	24	ignoring	ignore	VBG
cord-003921-8r8z0otz	73	25	the	the	DT
cord-003921-8r8z0otz	73	26	CXCL2	cxcl2	NN
cord-003921-8r8z0otz	73	27	attraction	attraction	NN
cord-003921-8r8z0otz	73	28	(	(	-LRB-
cord-003921-8r8z0otz	73	29	Fig	Fig	NNP
cord-003921-8r8z0otz	73	30	.	.	.
cord-003921-8r8z0otz	73	31	1c	1c	CD
cord-003921-8r8z0otz	73	32	)	)	-RRB-
cord-003921-8r8z0otz	73	33	.	.	.
cord-003921-8r8z0otz	74	1	Such	such	PDT
cord-003921-8r8z0otz	74	2	a	a	DT
cord-003921-8r8z0otz	74	3	chemotactic	chemotactic	JJ
cord-003921-8r8z0otz	74	4	hierarchy	hierarchy	NN
cord-003921-8r8z0otz	74	5	has	have	VBZ
cord-003921-8r8z0otz	74	6	been	be	VBN
cord-003921-8r8z0otz	74	7	consistently	consistently	RB
cord-003921-8r8z0otz	74	8	observed	observe	VBN
cord-003921-8r8z0otz	74	9	in	in	IN
cord-003921-8r8z0otz	74	10	pathogen	pathogen	NN
cord-003921-8r8z0otz	74	11	-	-	HYPH
cord-003921-8r8z0otz	74	12	triggered	trigger	VBN
cord-003921-8r8z0otz	74	13	infection	infection	NN
cord-003921-8r8z0otz	74	14	where	where	WRB
cord-003921-8r8z0otz	74	15	bacterial	bacterial	JJ
cord-003921-8r8z0otz	74	16	formylated	formylate	VBN
cord-003921-8r8z0otz	74	17	peptides	peptide	NNS
cord-003921-8r8z0otz	74	18	are	be	VBP
cord-003921-8r8z0otz	74	19	dominant	dominant	JJ
cord-003921-8r8z0otz	74	20	to	to	IN
cord-003921-8r8z0otz	74	21	endogenous	endogenous	JJ
cord-003921-8r8z0otz	74	22	chemoattractant	chemoattractant	NN
cord-003921-8r8z0otz	74	23	[	[	-LRB-
cord-003921-8r8z0otz	74	24	35	35	CD
cord-003921-8r8z0otz	74	25	]	]	-RRB-
cord-003921-8r8z0otz	74	26	,	,	,
cord-003921-8r8z0otz	74	27	as	as	RB
cord-003921-8r8z0otz	74	28	well	well	RB
cord-003921-8r8z0otz	74	29	as	as	IN
cord-003921-8r8z0otz	74	30	in	in	IN
cord-003921-8r8z0otz	74	31	sterile	sterile	JJ
cord-003921-8r8z0otz	74	32	inflammation	inflammation	NN
cord-003921-8r8z0otz	74	33	where	where	WRB
cord-003921-8r8z0otz	74	34	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	74	35	preferentially	preferentially	RB
cord-003921-8r8z0otz	74	36	migrated	migrate	VBD
cord-003921-8r8z0otz	74	37	toward	toward	IN
cord-003921-8r8z0otz	74	38	injured	injure	VBN
cord-003921-8r8z0otz	74	39	cells	cell	NNS
cord-003921-8r8z0otz	74	40	rather	rather	RB
cord-003921-8r8z0otz	74	41	than	than	IN
cord-003921-8r8z0otz	74	42	soluble	soluble	JJ
cord-003921-8r8z0otz	74	43	chemokines	chemokine	NNS
cord-003921-8r8z0otz	74	44	[	[	-LRB-
cord-003921-8r8z0otz	74	45	21	21	CD
cord-003921-8r8z0otz	74	46	]	]	-RRB-
cord-003921-8r8z0otz	74	47	.	.	.
cord-003921-8r8z0otz	75	1	Indeed	indeed	RB
cord-003921-8r8z0otz	75	2	,	,	,
cord-003921-8r8z0otz	75	3	Marques	Marques	NNP
cord-003921-8r8z0otz	75	4	et	et	NNP
cord-003921-8r8z0otz	75	5	al	al	NNP
cord-003921-8r8z0otz	75	6	.	.	NNP
cord-003921-8r8z0otz	75	7	demonstrated	demonstrate	VBD
cord-003921-8r8z0otz	75	8	that	that	IN
cord-003921-8r8z0otz	75	9	CXCR2	CXCR2	NNS
cord-003921-8r8z0otz	75	10	and	and	CC
cord-003921-8r8z0otz	75	11	FPR1	FPR1	NNP
cord-003921-8r8z0otz	75	12	antagonists	antagonist	NNS
cord-003921-8r8z0otz	75	13	alleviated	alleviate	VBD
cord-003921-8r8z0otz	75	14	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	75	15	migration	migration	NN
cord-003921-8r8z0otz	75	16	in	in	IN
cord-003921-8r8z0otz	75	17	acetaminophen	acetaminophen	NN
cord-003921-8r8z0otz	75	18	-	-	HYPH
cord-003921-8r8z0otz	75	19	induced	induce	VBN
cord-003921-8r8z0otz	75	20	liver	liver	NN
cord-003921-8r8z0otz	75	21	damage	damage	NN
cord-003921-8r8z0otz	75	22	,	,	,
cord-003921-8r8z0otz	75	23	while	while	IN
cord-003921-8r8z0otz	75	24	simultaneous	simultaneous	JJ
cord-003921-8r8z0otz	75	25	CXCR2	CXCR2	NNS
cord-003921-8r8z0otz	75	26	and	and	CC
cord-003921-8r8z0otz	75	27	FPR1	FPR1	NNP
cord-003921-8r8z0otz	75	28	antagonism	antagonism	NN
cord-003921-8r8z0otz	75	29	achieved	achieve	VBD
cord-003921-8r8z0otz	75	30	maximum	maximum	JJ
cord-003921-8r8z0otz	75	31	protection	protection	NN
cord-003921-8r8z0otz	75	32	[	[	-LRB-
cord-003921-8r8z0otz	75	33	36	36	CD
cord-003921-8r8z0otz	75	34	]	]	-RRB-
cord-003921-8r8z0otz	75	35	.	.	.
cord-003921-8r8z0otz	76	1	Hence	hence	RB
cord-003921-8r8z0otz	76	2	,	,	,
cord-003921-8r8z0otz	76	3	both	both	DT
cord-003921-8r8z0otz	76	4	CXCL2	CXCL2	NNS
cord-003921-8r8z0otz	76	5	and	and	CC
cord-003921-8r8z0otz	76	6	FMIT	FMIT	NNP
cord-003921-8r8z0otz	76	7	are	be	VBP
cord-003921-8r8z0otz	76	8	critically	critically	RB
cord-003921-8r8z0otz	76	9	involved	involve	VBN
cord-003921-8r8z0otz	76	10	in	in	IN
cord-003921-8r8z0otz	76	11	the	the	DT
cord-003921-8r8z0otz	76	12	hepatic	hepatic	JJ
cord-003921-8r8z0otz	76	13	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	76	14	migration	migration	NN
cord-003921-8r8z0otz	76	15	in	in	IN
cord-003921-8r8z0otz	76	16	a	a	DT
cord-003921-8r8z0otz	76	17	dynamic	dynamic	JJ
cord-003921-8r8z0otz	76	18	and	and	CC
cord-003921-8r8z0otz	76	19	sequential	sequential	JJ
cord-003921-8r8z0otz	76	20	manner	manner	NN
cord-003921-8r8z0otz	76	21	.	.	.
cord-003921-8r8z0otz	77	1	The	the	DT
cord-003921-8r8z0otz	77	2	extracellular	extracellular	JJ
cord-003921-8r8z0otz	77	3	matrix	matrix	NN
cord-003921-8r8z0otz	77	4	(	(	-LRB-
cord-003921-8r8z0otz	77	5	ECM	ECM	NNP
cord-003921-8r8z0otz	77	6	)	)	-RRB-
cord-003921-8r8z0otz	77	7	,	,	,
cord-003921-8r8z0otz	77	8	a	a	DT
cord-003921-8r8z0otz	77	9	network	network	NN
cord-003921-8r8z0otz	77	10	of	of	IN
cord-003921-8r8z0otz	77	11	proteins	protein	NNS
cord-003921-8r8z0otz	77	12	and	and	CC
cord-003921-8r8z0otz	77	13	sugars	sugar	NNS
cord-003921-8r8z0otz	77	14	in	in	IN
cord-003921-8r8z0otz	77	15	all	all	DT
cord-003921-8r8z0otz	77	16	solid	solid	JJ
cord-003921-8r8z0otz	77	17	organs	organ	NNS
cord-003921-8r8z0otz	77	18	,	,	,
cord-003921-8r8z0otz	77	19	is	be	VBZ
cord-003921-8r8z0otz	77	20	the	the	DT
cord-003921-8r8z0otz	77	21	essential	essential	JJ
cord-003921-8r8z0otz	77	22	scaffold	scaffold	NN
cord-003921-8r8z0otz	77	23	and	and	CC
cord-003921-8r8z0otz	77	24	structural	structural	JJ
cord-003921-8r8z0otz	77	25	cell	cell	NN
cord-003921-8r8z0otz	77	26	support	support	NN
cord-003921-8r8z0otz	77	27	as	as	RB
cord-003921-8r8z0otz	77	28	well	well	RB
cord-003921-8r8z0otz	77	29	as	as	IN
cord-003921-8r8z0otz	77	30	tissue	tissue	NN
cord-003921-8r8z0otz	77	31	regulator	regulator	NN
cord-003921-8r8z0otz	77	32	of	of	IN
cord-003921-8r8z0otz	77	33	cell	cell	NN
cord-003921-8r8z0otz	77	34	adhesion	adhesion	NN
cord-003921-8r8z0otz	77	35	,	,	,
cord-003921-8r8z0otz	77	36	migration	migration	NN
cord-003921-8r8z0otz	77	37	,	,	,
cord-003921-8r8z0otz	77	38	differentiation	differentiation	NN
cord-003921-8r8z0otz	77	39	,	,	,
cord-003921-8r8z0otz	77	40	proliferation	proliferation	NN
cord-003921-8r8z0otz	77	41	,	,	,
cord-003921-8r8z0otz	77	42	and	and	CC
cord-003921-8r8z0otz	77	43	survival	survival	NN
cord-003921-8r8z0otz	77	44	.	.	.
cord-003921-8r8z0otz	78	1	Once	once	IN
cord-003921-8r8z0otz	78	2	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	78	3	migrate	migrate	VBP
cord-003921-8r8z0otz	78	4	across	across	IN
cord-003921-8r8z0otz	78	5	LSEC	LSEC	NNP
cord-003921-8r8z0otz	78	6	,	,	,
cord-003921-8r8z0otz	78	7	they	-PRON-	PRP
cord-003921-8r8z0otz	78	8	move	move	VBP
cord-003921-8r8z0otz	78	9	toward	toward	IN
cord-003921-8r8z0otz	78	10	damaged	damage	VBN
cord-003921-8r8z0otz	78	11	site	site	NN
cord-003921-8r8z0otz	78	12	while	while	IN
cord-003921-8r8z0otz	78	13	simultaneously	simultaneously	RB
cord-003921-8r8z0otz	78	14	degrading	degrade	VBG
cord-003921-8r8z0otz	78	15	ECM	ECM	NNP
cord-003921-8r8z0otz	78	16	.	.	.
cord-003921-8r8z0otz	79	1	This	this	DT
cord-003921-8r8z0otz	79	2	process	process	NN
cord-003921-8r8z0otz	79	3	is	be	VBZ
cord-003921-8r8z0otz	79	4	dominated	dominate	VBN
cord-003921-8r8z0otz	79	5	by	by	IN
cord-003921-8r8z0otz	79	6	matrix	matrix	NN
cord-003921-8r8z0otz	79	7	metalloproteinases	metalloproteinase	NNS
cord-003921-8r8z0otz	79	8	(	(	-LRB-
cord-003921-8r8z0otz	79	9	MMPs	MMPs	NNP
cord-003921-8r8z0otz	79	10	)	)	-RRB-
cord-003921-8r8z0otz	79	11	,	,	,
cord-003921-8r8z0otz	79	12	zincdependent	zincdependent	NNP
cord-003921-8r8z0otz	79	13	endopeptidases	endopeptidase	NNS
cord-003921-8r8z0otz	79	14	involved	involve	VBN
cord-003921-8r8z0otz	79	15	in	in	IN
cord-003921-8r8z0otz	79	16	the	the	DT
cord-003921-8r8z0otz	79	17	breakdown	breakdown	NN
cord-003921-8r8z0otz	79	18	of	of	IN
cord-003921-8r8z0otz	79	19	ECM	ECM	NNP
cord-003921-8r8z0otz	79	20	,	,	,
cord-003921-8r8z0otz	79	21	and	and	CC
cord-003921-8r8z0otz	79	22	tissue	tissue	NN
cord-003921-8r8z0otz	79	23	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	79	24	of	of	IN
cord-003921-8r8z0otz	79	25	metalloproteinases	metalloproteinase	NNS
cord-003921-8r8z0otz	79	26	(	(	-LRB-
cord-003921-8r8z0otz	79	27	TIMPs	TIMPs	NNP
cord-003921-8r8z0otz	79	28	)	)	-RRB-
cord-003921-8r8z0otz	79	29	,	,	,
cord-003921-8r8z0otz	79	30	which	which	WDT
cord-003921-8r8z0otz	79	31	proteolytically	proteolytically	RB
cord-003921-8r8z0otz	79	32	regulate	regulate	VBP
cord-003921-8r8z0otz	79	33	MMPs	mmps	NN
cord-003921-8r8z0otz	79	34	activity	activity	NN
cord-003921-8r8z0otz	79	35	.	.	.
cord-003921-8r8z0otz	80	1	MMP2	MMP2	NNP
cord-003921-8r8z0otz	80	2	and	and	CC
cord-003921-8r8z0otz	80	3	MMP9	MMP9	NNP
cord-003921-8r8z0otz	80	4	are	be	VBP
cord-003921-8r8z0otz	80	5	the	the	DT
cord-003921-8r8z0otz	80	6	most	most	RBS
cord-003921-8r8z0otz	80	7	prominent	prominent	JJ
cord-003921-8r8z0otz	80	8	in	in	IN
cord-003921-8r8z0otz	80	9	the	the	DT
cord-003921-8r8z0otz	80	10	pathophysiology	pathophysiology	NN
cord-003921-8r8z0otz	80	11	of	of	IN
cord-003921-8r8z0otz	80	12	liver	liver	NN
cord-003921-8r8z0otz	80	13	IRI	IRI	NNP
cord-003921-8r8z0otz	80	14	[	[	-LRB-
cord-003921-8r8z0otz	80	15	37	37	CD
cord-003921-8r8z0otz	80	16	]	]	-RRB-
cord-003921-8r8z0otz	80	17	.	.	.
cord-003921-8r8z0otz	81	1	In	in	IN
cord-003921-8r8z0otz	81	2	liver	liver	NN
cord-003921-8r8z0otz	81	3	IRI	IRI	NNP
cord-003921-8r8z0otz	81	4	,	,	,
cord-003921-8r8z0otz	81	5	MMP9	MMP9	NNP
cord-003921-8r8z0otz	81	6	is	be	VBZ
cord-003921-8r8z0otz	81	7	predominantly	predominantly	RB
cord-003921-8r8z0otz	81	8	expressed	express	VBN
cord-003921-8r8z0otz	81	9	by	by	IN
cord-003921-8r8z0otz	81	10	Ly6G	ly6g	JJ
cord-003921-8r8z0otz	81	11	-	-	HYPH
cord-003921-8r8z0otz	81	12	positive	positive	JJ
cord-003921-8r8z0otz	81	13	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	81	14	,	,	,
cord-003921-8r8z0otz	81	15	while	while	IN
cord-003921-8r8z0otz	81	16	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	81	17	are	be	VBP
cord-003921-8r8z0otz	81	18	the	the	DT
cord-003921-8r8z0otz	81	19	only	only	JJ
cord-003921-8r8z0otz	81	20	cells	cell	NNS
cord-003921-8r8z0otz	81	21	in	in	IN
cord-003921-8r8z0otz	81	22	the	the	DT
cord-003921-8r8z0otz	81	23	body	body	NN
cord-003921-8r8z0otz	81	24	which	which	WDT
cord-003921-8r8z0otz	81	25	can	can	MD
cord-003921-8r8z0otz	81	26	release	release	VB
cord-003921-8r8z0otz	81	27	MMP9	MMP9	NNP
cord-003921-8r8z0otz	81	28	free	free	JJ
cord-003921-8r8z0otz	81	29	of	of	IN
cord-003921-8r8z0otz	81	30	its	-PRON-	PRP$
cord-003921-8r8z0otz	81	31	endogenous	endogenous	JJ
cord-003921-8r8z0otz	81	32	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	81	33	TIMPs	TIMPs	NNP
cord-003921-8r8z0otz	81	34	,	,	,
cord-003921-8r8z0otz	81	35	and	and	CC
cord-003921-8r8z0otz	81	36	therefore	therefore	RB
cord-003921-8r8z0otz	81	37	are	be	VBP
cord-003921-8r8z0otz	81	38	uniquely	uniquely	RB
cord-003921-8r8z0otz	81	39	capable	capable	JJ
cord-003921-8r8z0otz	81	40	of	of	IN
cord-003921-8r8z0otz	81	41	delivering	deliver	VBG
cord-003921-8r8z0otz	81	42	highly	highly	RB
cord-003921-8r8z0otz	81	43	active	active	JJ
cord-003921-8r8z0otz	81	44	MMP9	MMP9	NNP
cord-003921-8r8z0otz	81	45	to	to	TO
cord-003921-8r8z0otz	81	46	digest	digest	VB
cord-003921-8r8z0otz	81	47	its	-PRON-	PRP$
cord-003921-8r8z0otz	81	48	fibronectin	fibronectin	NN
cord-003921-8r8z0otz	81	49	and	and	CC
cord-003921-8r8z0otz	81	50	collagen	collagen	NN
cord-003921-8r8z0otz	81	51	type	type	NN
cord-003921-8r8z0otz	81	52	IV	IV	NNP
cord-003921-8r8z0otz	81	53	substrates	substrate	NNS
cord-003921-8r8z0otz	81	54	[	[	-LRB-
cord-003921-8r8z0otz	81	55	38	38	CD
cord-003921-8r8z0otz	81	56	]	]	-RRB-
cord-003921-8r8z0otz	81	57	.	.	.
cord-003921-8r8z0otz	82	1	Fibronectin	Fibronectin	NNP
cord-003921-8r8z0otz	82	2	,	,	,
cord-003921-8r8z0otz	82	3	a	a	DT
cord-003921-8r8z0otz	82	4	major	major	JJ
cord-003921-8r8z0otz	82	5	ECM	ECM	NNP
cord-003921-8r8z0otz	82	6	component	component	NN
cord-003921-8r8z0otz	82	7	of	of	IN
cord-003921-8r8z0otz	82	8	the	the	DT
cord-003921-8r8z0otz	82	9	subendothelial	subendothelial	JJ
cord-003921-8r8z0otz	82	10	space	space	NN
cord-003921-8r8z0otz	82	11	of	of	IN
cord-003921-8r8z0otz	82	12	Disse	Disse	NNP
cord-003921-8r8z0otz	82	13	in	in	IN
cord-003921-8r8z0otz	82	14	normal	normal	JJ
cord-003921-8r8z0otz	82	15	liver	liver	NN
cord-003921-8r8z0otz	82	16	,	,	,
cord-003921-8r8z0otz	82	17	interacts	interact	VBZ
cord-003921-8r8z0otz	82	18	with	with	IN
cord-003921-8r8z0otz	82	19	integrin	integrin	JJ
cord-003921-8r8z0otz	82	20	receptor	receptor	NN
cord-003921-8r8z0otz	82	21	α4β1	α4β1	NN
cord-003921-8r8z0otz	82	22	on	on	IN
cord-003921-8r8z0otz	82	23	activated	activate	VBN
cord-003921-8r8z0otz	82	24	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	82	25	to	to	TO
cord-003921-8r8z0otz	82	26	induce	induce	VB
cord-003921-8r8z0otz	82	27	MMP9	MMP9	NNP
cord-003921-8r8z0otz	82	28	[	[	-LRB-
cord-003921-8r8z0otz	82	29	39	39	CD
cord-003921-8r8z0otz	82	30	]	]	-RRB-
cord-003921-8r8z0otz	83	1	(	(	-LRB-
cord-003921-8r8z0otz	83	2	Fig	Fig	NNP
cord-003921-8r8z0otz	83	3	.	.	.
cord-003921-8r8z0otz	83	4	1d	1d	CD
cord-003921-8r8z0otz	83	5	)	)	-RRB-
cord-003921-8r8z0otz	83	6	.	.	.
cord-003921-8r8z0otz	84	1	Hamada	Hamada	NNP
cord-003921-8r8z0otz	84	2	et	et	NNP
cord-003921-8r8z0otz	84	3	al	al	NNP
cord-003921-8r8z0otz	84	4	.	.	NNP
cord-003921-8r8z0otz	84	5	demonstrated	demonstrate	VBD
cord-003921-8r8z0otz	84	6	that	that	IN
cord-003921-8r8z0otz	84	7	MMP9	MMP9	NNP
cord-003921-8r8z0otz	84	8	deficient	deficient	JJ
cord-003921-8r8z0otz	84	9	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	84	10	were	be	VBD
cord-003921-8r8z0otz	84	11	impaired	impair	VBN
cord-003921-8r8z0otz	84	12	in	in	IN
cord-003921-8r8z0otz	84	13	their	-PRON-	PRP$
cord-003921-8r8z0otz	84	14	ability	ability	NN
cord-003921-8r8z0otz	84	15	to	to	TO
cord-003921-8r8z0otz	84	16	migrate	migrate	VB
cord-003921-8r8z0otz	84	17	across	across	IN
cord-003921-8r8z0otz	84	18	fibronectin	fibronectin	NN
cord-003921-8r8z0otz	84	19	in	in	IN
cord-003921-8r8z0otz	84	20	a	a	DT
cord-003921-8r8z0otz	84	21	transwell	transwell	NNP
cord-003921-8r8z0otz	84	22	culture	culture	NN
cord-003921-8r8z0otz	84	23	system	system	NN
cord-003921-8r8z0otz	84	24	,	,	,
cord-003921-8r8z0otz	84	25	whereas	whereas	IN
cord-003921-8r8z0otz	84	26	genetic	genetic	JJ
cord-003921-8r8z0otz	84	27	disruption	disruption	NN
cord-003921-8r8z0otz	84	28	or	or	CC
cord-003921-8r8z0otz	84	29	exogenous	exogenous	JJ
cord-003921-8r8z0otz	84	30	blocking	blocking	NN
cord-003921-8r8z0otz	84	31	with	with	IN
cord-003921-8r8z0otz	84	32	MMP9	MMP9	NNP
cord-003921-8r8z0otz	84	33	antibody	antibody	NN
cord-003921-8r8z0otz	84	34	decreased	decrease	VBD
cord-003921-8r8z0otz	84	35	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	84	36	infiltration	infiltration	NN
cord-003921-8r8z0otz	84	37	and	and	CC
cord-003921-8r8z0otz	84	38	cytoprotection	cytoprotection	NN
cord-003921-8r8z0otz	84	39	in	in	IN
cord-003921-8r8z0otz	84	40	a	a	DT
cord-003921-8r8z0otz	84	41	mouse	mouse	NN
cord-003921-8r8z0otz	84	42	hepatic	hepatic	JJ
cord-003921-8r8z0otz	84	43	IRI	IRI	NNP
cord-003921-8r8z0otz	84	44	model	model	NN
cord-003921-8r8z0otz	84	45	[	[	-LRB-
cord-003921-8r8z0otz	84	46	40	40	CD
cord-003921-8r8z0otz	84	47	]	]	-RRB-
cord-003921-8r8z0otz	84	48	.	.	.
cord-003921-8r8z0otz	85	1	Meantime	meantime	RB
cord-003921-8r8z0otz	85	2	,	,	,
cord-003921-8r8z0otz	85	3	IR	IR	NNP
cord-003921-8r8z0otz	85	4	-	-	HYPH
cord-003921-8r8z0otz	85	5	insult	insult	NN
cord-003921-8r8z0otz	85	6	markedly	markedly	RB
cord-003921-8r8z0otz	85	7	increases	increase	VBZ
cord-003921-8r8z0otz	85	8	TIMP1	timp1	NN
cord-003921-8r8z0otz	85	9	expression	expression	NN
cord-003921-8r8z0otz	85	10	,	,	,
cord-003921-8r8z0otz	85	11	an	an	DT
cord-003921-8r8z0otz	85	12	endogenous	endogenous	JJ
cord-003921-8r8z0otz	85	13	MMP9	MMP9	NNP
cord-003921-8r8z0otz	85	14	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	85	15	.	.	.
cord-003921-8r8z0otz	86	1	Indeed	indeed	RB
cord-003921-8r8z0otz	86	2	,	,	,
cord-003921-8r8z0otz	86	3	TIMP1	TIMP1	NNP
cord-003921-8r8z0otz	86	4	deficient	deficient	JJ
cord-003921-8r8z0otz	86	5	mice	mouse	NNS
cord-003921-8r8z0otz	86	6	had	have	VBD
cord-003921-8r8z0otz	86	7	markedly	markedly	RB
cord-003921-8r8z0otz	86	8	increased	increase	VBN
cord-003921-8r8z0otz	86	9	MMP9	MMP9	NNP
cord-003921-8r8z0otz	86	10	activity	activity	NN
cord-003921-8r8z0otz	86	11	and	and	CC
cord-003921-8r8z0otz	86	12	massive	massive	JJ
cord-003921-8r8z0otz	86	13	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	86	14	infiltration	infiltration	NN
cord-003921-8r8z0otz	86	15	in	in	IN
cord-003921-8r8z0otz	86	16	their	-PRON-	PRP$
cord-003921-8r8z0otz	86	17	IR	IR	NNP
cord-003921-8r8z0otz	86	18	-	-	HYPH
cord-003921-8r8z0otz	86	19	stressed	stress	VBN
cord-003921-8r8z0otz	86	20	livers	liver	NNS
cord-003921-8r8z0otz	86	21	,	,	,
cord-003921-8r8z0otz	86	22	which	which	WDT
cord-003921-8r8z0otz	86	23	has	have	VBZ
cord-003921-8r8z0otz	86	24	led	lead	VBN
cord-003921-8r8z0otz	86	25	to	to	IN
cord-003921-8r8z0otz	86	26	60	60	CD
cord-003921-8r8z0otz	86	27	%	%	NN
cord-003921-8r8z0otz	86	28	death	death	NN
cord-003921-8r8z0otz	86	29	.	.	.
cord-003921-8r8z0otz	87	1	In	in	IN
cord-003921-8r8z0otz	87	2	contrast	contrast	NN
cord-003921-8r8z0otz	87	3	,	,	,
cord-003921-8r8z0otz	87	4	virus	virus	NN
cord-003921-8r8z0otz	87	5	-	-	HYPH
cord-003921-8r8z0otz	87	6	mediated	mediate	VBN
cord-003921-8r8z0otz	87	7	gene	gene	NN
cord-003921-8r8z0otz	87	8	transfer	transfer	NN
cord-003921-8r8z0otz	87	9	of	of	IN
cord-003921-8r8z0otz	87	10	TIMP1	TIMP1	NNP
cord-003921-8r8z0otz	87	11	increased	increase	VBN
cord-003921-8r8z0otz	87	12	TIMP1	TIMP1	NNP
cord-003921-8r8z0otz	87	13	expression	expression	NN
cord-003921-8r8z0otz	87	14	primarily	primarily	RB
cord-003921-8r8z0otz	87	15	on	on	IN
cord-003921-8r8z0otz	87	16	parenchymal	parenchymal	JJ
cord-003921-8r8z0otz	87	17	cells	cell	NNS
cord-003921-8r8z0otz	87	18	,	,	,
cord-003921-8r8z0otz	87	19	suppressed	suppress	VBD
cord-003921-8r8z0otz	87	20	gelatinolytic	gelatinolytic	JJ
cord-003921-8r8z0otz	87	21	activity	activity	NN
cord-003921-8r8z0otz	87	22	of	of	IN
cord-003921-8r8z0otz	87	23	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	87	24	MMP9	MMP9	NNP
cord-003921-8r8z0otz	87	25	,	,	,
cord-003921-8r8z0otz	87	26	attenuated	attenuated	JJ
cord-003921-8r8z0otz	87	27	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	87	28	infiltration	infiltration	NN
cord-003921-8r8z0otz	87	29	,	,	,
cord-003921-8r8z0otz	87	30	and	and	CC
cord-003921-8r8z0otz	87	31	alleviated	alleviate	VBD
cord-003921-8r8z0otz	87	32	the	the	DT
cord-003921-8r8z0otz	87	33	hepatocellular	hepatocellular	JJ
cord-003921-8r8z0otz	87	34	damage	damage	NN
cord-003921-8r8z0otz	87	35	[	[	-LRB-
cord-003921-8r8z0otz	87	36	41	41	CD
cord-003921-8r8z0otz	87	37	,	,	,
cord-003921-8r8z0otz	87	38	42	42	CD
cord-003921-8r8z0otz	87	39	]	]	-RRB-
cord-003921-8r8z0otz	87	40	.	.	.
cord-003921-8r8z0otz	88	1	Furthermore	furthermore	RB
cord-003921-8r8z0otz	88	2	,	,	,
cord-003921-8r8z0otz	88	3	LT	LT	NNP
cord-003921-8r8z0otz	88	4	patients	patient	NNS
cord-003921-8r8z0otz	88	5	experiencing	experience	VBG
cord-003921-8r8z0otz	88	6	acute	acute	JJ
cord-003921-8r8z0otz	88	7	rejection	rejection	NN
cord-003921-8r8z0otz	88	8	had	have	VBD
cord-003921-8r8z0otz	88	9	elevated	elevate	VBN
cord-003921-8r8z0otz	88	10	serum	serum	NN
cord-003921-8r8z0otz	88	11	MMP9	MMP9	NNP
cord-003921-8r8z0otz	88	12	activity	activity	NN
cord-003921-8r8z0otz	88	13	at	at	IN
cord-003921-8r8z0otz	88	14	1	1	CD
cord-003921-8r8z0otz	88	15	week	week	NN
cord-003921-8r8z0otz	88	16	,	,	,
cord-003921-8r8z0otz	88	17	implying	imply	VBG
cord-003921-8r8z0otz	88	18	its	-PRON-	PRP$
cord-003921-8r8z0otz	88	19	role	role	NN
cord-003921-8r8z0otz	88	20	as	as	IN
cord-003921-8r8z0otz	88	21	a	a	DT
cord-003921-8r8z0otz	88	22	potential	potential	JJ
cord-003921-8r8z0otz	88	23	biomarker	biomarker	NN
cord-003921-8r8z0otz	88	24	in	in	IN
cord-003921-8r8z0otz	88	25	clinical	clinical	JJ
cord-003921-8r8z0otz	88	26	LT	LT	NNP
cord-003921-8r8z0otz	88	27	[	[	-LRB-
cord-003921-8r8z0otz	88	28	43	43	CD
cord-003921-8r8z0otz	88	29	]	]	-RRB-
cord-003921-8r8z0otz	88	30	.	.	.
cord-003921-8r8z0otz	89	1	Neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	89	2	recruited	recruit	VBN
cord-003921-8r8z0otz	89	3	or	or	CC
cord-003921-8r8z0otz	89	4	activated	activate	VBN
cord-003921-8r8z0otz	89	5	in	in	IN
cord-003921-8r8z0otz	89	6	liver	liver	NN
cord-003921-8r8z0otz	89	7	sinusoids	sinusoid	NNS
cord-003921-8r8z0otz	89	8	do	do	VBP
cord-003921-8r8z0otz	89	9	not	not	RB
cord-003921-8r8z0otz	89	10	cause	cause	VB
cord-003921-8r8z0otz	89	11	hepatic	hepatic	JJ
cord-003921-8r8z0otz	89	12	damage	damage	NN
cord-003921-8r8z0otz	89	13	per	per	IN
cord-003921-8r8z0otz	89	14	se	se	FW
cord-003921-8r8z0otz	89	15	,	,	,
cord-003921-8r8z0otz	89	16	as	as	IN
cord-003921-8r8z0otz	89	17	they	-PRON-	PRP
cord-003921-8r8z0otz	89	18	can	can	MD
cord-003921-8r8z0otz	89	19	exert	exert	VB
cord-003921-8r8z0otz	89	20	cytotoxicity	cytotoxicity	NN
cord-003921-8r8z0otz	89	21	only	only	RB
cord-003921-8r8z0otz	89	22	after	after	IN
cord-003921-8r8z0otz	89	23	migrating	migrate	VBG
cord-003921-8r8z0otz	89	24	across	across	IN
cord-003921-8r8z0otz	89	25	the	the	DT
cord-003921-8r8z0otz	89	26	endothelium	endothelium	NN
cord-003921-8r8z0otz	89	27	and	and	CC
cord-003921-8r8z0otz	89	28	in	in	IN
cord-003921-8r8z0otz	89	29	close	close	JJ
cord-003921-8r8z0otz	89	30	proximity	proximity	NN
cord-003921-8r8z0otz	89	31	to	to	IN
cord-003921-8r8z0otz	89	32	the	the	DT
cord-003921-8r8z0otz	89	33	parenchymal	parenchymal	NN
cord-003921-8r8z0otz	89	34	cells	cell	NNS
cord-003921-8r8z0otz	89	35	[	[	-LRB-
cord-003921-8r8z0otz	89	36	17	17	CD
cord-003921-8r8z0otz	89	37	]	]	-RRB-
cord-003921-8r8z0otz	89	38	.	.	.
cord-003921-8r8z0otz	90	1	Tissue	tissue	NN
cord-003921-8r8z0otz	90	2	damage	damage	NN
cord-003921-8r8z0otz	90	3	is	be	VBZ
cord-003921-8r8z0otz	90	4	mediated	mediate	VBN
cord-003921-8r8z0otz	90	5	primarily	primarily	RB
cord-003921-8r8z0otz	90	6	by	by	IN
cord-003921-8r8z0otz	90	7	ROS	ROS	NNP
cord-003921-8r8z0otz	90	8	and	and	CC
cord-003921-8r8z0otz	90	9	proteases	protease	NNS
cord-003921-8r8z0otz	90	10	,	,	,
cord-003921-8r8z0otz	90	11	with	with	IN
cord-003921-8r8z0otz	90	12	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	90	13	cells	cell	NNS
cord-003921-8r8z0otz	90	14	being	be	VBG
cord-003921-8r8z0otz	90	15	principal	principal	JJ
cord-003921-8r8z0otz	90	16	ROS	ROS	NNP
cord-003921-8r8z0otz	90	17	producers	producer	NNS
cord-003921-8r8z0otz	90	18	early	early	RB
cord-003921-8r8z0otz	90	19	after	after	IN
cord-003921-8r8z0otz	90	20	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	90	21	,	,	,
cord-003921-8r8z0otz	90	22	and	and	CC
cord-003921-8r8z0otz	90	23	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	90	24	oxidative	oxidative	JJ
cord-003921-8r8z0otz	90	25	burst	burst	NN
cord-003921-8r8z0otz	90	26	becoming	become	VBG
cord-003921-8r8z0otz	90	27	the	the	DT
cord-003921-8r8z0otz	90	28	main	main	JJ
cord-003921-8r8z0otz	90	29	source	source	NN
cord-003921-8r8z0otz	90	30	of	of	IN
cord-003921-8r8z0otz	90	31	ROS	ROS	NNP
cord-003921-8r8z0otz	90	32	in	in	IN
cord-003921-8r8z0otz	90	33	the	the	DT
cord-003921-8r8z0otz	90	34	later	later	JJ
cord-003921-8r8z0otz	90	35	IRI	IRI	NNP
cord-003921-8r8z0otz	90	36	phase	phase	NN
cord-003921-8r8z0otz	90	37	.	.	.
cord-003921-8r8z0otz	91	1	Indeed	indeed	RB
cord-003921-8r8z0otz	91	2	,	,	,
cord-003921-8r8z0otz	91	3	by	by	IN
cord-003921-8r8z0otz	91	4	6	6	CD
cord-003921-8r8z0otz	91	5	h	h	NN
cord-003921-8r8z0otz	91	6	of	of	IN
cord-003921-8r8z0otz	91	7	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	91	8	(	(	-LRB-
cord-003921-8r8z0otz	91	9	the	the	DT
cord-003921-8r8z0otz	91	10	peak	peak	NN
cord-003921-8r8z0otz	91	11	of	of	IN
cord-003921-8r8z0otz	91	12	hepatocellular	hepatocellular	JJ
cord-003921-8r8z0otz	91	13	damage	damage	NN
cord-003921-8r8z0otz	91	14	in	in	IN
cord-003921-8r8z0otz	91	15	a	a	DT
cord-003921-8r8z0otz	91	16	murine	murine	JJ
cord-003921-8r8z0otz	91	17	IRI	IRI	NNP
cord-003921-8r8z0otz	91	18	-	-	HYPH
cord-003921-8r8z0otz	91	19	LT	LT	NNP
cord-003921-8r8z0otz	91	20	model	model	NN
cord-003921-8r8z0otz	91	21	)	)	-RRB-
cord-003921-8r8z0otz	91	22	,	,	,
cord-003921-8r8z0otz	91	23	infiltrating	infiltrate	VBG
cord-003921-8r8z0otz	91	24	Ly6G	ly6g	RB
cord-003921-8r8z0otz	91	25	-	-	HYPH
cord-003921-8r8z0otz	91	26	positive	positive	JJ
cord-003921-8r8z0otz	91	27	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	91	28	elaborated	elaborate	VBD
cord-003921-8r8z0otz	91	29	large	large	JJ
cord-003921-8r8z0otz	91	30	amounts	amount	NNS
cord-003921-8r8z0otz	91	31	of	of	IN
cord-003921-8r8z0otz	91	32	ROS	ROS	NNP
cord-003921-8r8z0otz	91	33	metabolite	metabolite	NN
cord-003921-8r8z0otz	91	34	(	(	-LRB-
cord-003921-8r8z0otz	91	35	4-hydroxynonenal	4-hydroxynonenal	CD
cord-003921-8r8z0otz	91	36	)	)	-RRB-
cord-003921-8r8z0otz	91	37	[	[	-LRB-
cord-003921-8r8z0otz	91	38	11	11	CD
cord-003921-8r8z0otz	91	39	]	]	-RRB-
cord-003921-8r8z0otz	91	40	.	.	.
cord-003921-8r8z0otz	92	1	Neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	92	2	generate	generate	VBP
cord-003921-8r8z0otz	92	3	ROS	ROS	NNP
cord-003921-8r8z0otz	92	4	through	through	IN
cord-003921-8r8z0otz	92	5	nicotinamide	nicotinamide	NN
cord-003921-8r8z0otz	92	6	adenine	adenine	NN
cord-003921-8r8z0otz	92	7	dinucleotide	dinucleotide	NN
cord-003921-8r8z0otz	92	8	phosphate	phosphate	NN
cord-003921-8r8z0otz	93	1	(	(	-LRB-
cord-003921-8r8z0otz	93	2	NADPH	NADPH	NNP
cord-003921-8r8z0otz	93	3	)	)	-RRB-
cord-003921-8r8z0otz	93	4	oxidase	oxidase	NN
cord-003921-8r8z0otz	93	5	,	,	,
cord-003921-8r8z0otz	93	6	which	which	WDT
cord-003921-8r8z0otz	93	7	consists	consist	VBZ
cord-003921-8r8z0otz	93	8	of	of	IN
cord-003921-8r8z0otz	93	9	a	a	DT
cord-003921-8r8z0otz	93	10	Rho	Rho	NNP
cord-003921-8r8z0otz	93	11	GTPase	GTPase	NNP
cord-003921-8r8z0otz	93	12	,	,	,
cord-003921-8r8z0otz	93	13	two	two	CD
cord-003921-8r8z0otz	93	14	membrane	membrane	NN
cord-003921-8r8z0otz	93	15	-	-	HYPH
cord-003921-8r8z0otz	93	16	bound	bind	VBN
cord-003921-8r8z0otz	93	17	phox	phox	NN
cord-003921-8r8z0otz	93	18	(	(	-LRB-
cord-003921-8r8z0otz	93	19	phagocytic	phagocytic	JJ
cord-003921-8r8z0otz	93	20	oxidase	oxidase	NN
cord-003921-8r8z0otz	93	21	)	)	-RRB-
cord-003921-8r8z0otz	93	22	proteins	protein	NNS
cord-003921-8r8z0otz	93	23	(	(	-LRB-
cord-003921-8r8z0otz	93	24	p22	p22	NN
cord-003921-8r8z0otz	93	25	phox	phox	NNP
cord-003921-8r8z0otz	93	26	and	and	CC
cord-003921-8r8z0otz	93	27	gp91	gp91	NNP
cord-003921-8r8z0otz	93	28	phox	phox	NNP
cord-003921-8r8z0otz	93	29	)	)	-RRB-
cord-003921-8r8z0otz	93	30	,	,	,
cord-003921-8r8z0otz	93	31	and	and	CC
cord-003921-8r8z0otz	93	32	three	three	CD
cord-003921-8r8z0otz	93	33	cytosolic	cytosolic	JJ
cord-003921-8r8z0otz	93	34	phox	phox	NN
cord-003921-8r8z0otz	93	35	proteins	protein	NNS
cord-003921-8r8z0otz	93	36	(	(	-LRB-
cord-003921-8r8z0otz	93	37	p40	p40	NN
cord-003921-8r8z0otz	93	38	phox	phox	NNP
cord-003921-8r8z0otz	93	39	,	,	,
cord-003921-8r8z0otz	93	40	p47	p47	CD
cord-003921-8r8z0otz	93	41	phox	phox	NNP
cord-003921-8r8z0otz	93	42	,	,	,
cord-003921-8r8z0otz	93	43	and	and	CC
cord-003921-8r8z0otz	93	44	p67	p67	NNP
cord-003921-8r8z0otz	93	45	phox	phox	NNP
cord-003921-8r8z0otz	93	46	)	)	-RRB-
cord-003921-8r8z0otz	93	47	.	.	.
cord-003921-8r8z0otz	94	1	Patients	patient	NNS
cord-003921-8r8z0otz	94	2	encoded	encode	VBN
cord-003921-8r8z0otz	94	3	with	with	IN
cord-003921-8r8z0otz	94	4	hypofunctional	hypofunctional	JJ
cord-003921-8r8z0otz	94	5	mutations	mutation	NNS
cord-003921-8r8z0otz	94	6	in	in	IN
cord-003921-8r8z0otz	94	7	gp91	gp91	NNP
cord-003921-8r8z0otz	94	8	phox	phox	NNP
cord-003921-8r8z0otz	94	9	or	or	CC
cord-003921-8r8z0otz	94	10	p47	p47	CD
cord-003921-8r8z0otz	94	11	phox	phox	NNS
cord-003921-8r8z0otz	94	12	were	be	VBD
cord-003921-8r8z0otz	94	13	protected	protect	VBN
cord-003921-8r8z0otz	94	14	from	from	IN
cord-003921-8r8z0otz	94	15	transiently	transiently	RB
cord-003921-8r8z0otz	94	16	induced	induce	VBN
cord-003921-8r8z0otz	94	17	upper	upper	JJ
cord-003921-8r8z0otz	94	18	limb	limb	NN
cord-003921-8r8z0otz	94	19	IRI	IRI	NNP
cord-003921-8r8z0otz	94	20	[	[	-LRB-
cord-003921-8r8z0otz	94	21	44	44	CD
cord-003921-8r8z0otz	94	22	]	]	-RRB-
cord-003921-8r8z0otz	94	23	,	,	,
cord-003921-8r8z0otz	94	24	while	while	IN
cord-003921-8r8z0otz	94	25	apocynin	apocynin	NNP
cord-003921-8r8z0otz	94	26	(	(	-LRB-
cord-003921-8r8z0otz	94	27	gp91	gp91	NNP
cord-003921-8r8z0otz	94	28	phox	phox	NNP
cord-003921-8r8z0otz	94	29	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	94	30	)	)	-RRB-
cord-003921-8r8z0otz	94	31	suppressed	suppress	VBD
cord-003921-8r8z0otz	94	32	ROS	ROS	NNP
cord-003921-8r8z0otz	94	33	metabolite	metabolite	NN
cord-003921-8r8z0otz	94	34	(	(	-LRB-
cord-003921-8r8z0otz	94	35	8hydroxy-2-deoxyguanosine	8hydroxy-2-deoxyguanosine	NN
cord-003921-8r8z0otz	94	36	)	)	-RRB-
cord-003921-8r8z0otz	94	37	and	and	CC
cord-003921-8r8z0otz	94	38	alleviated	alleviate	VBD
cord-003921-8r8z0otz	94	39	liver	liver	NN
cord-003921-8r8z0otz	94	40	IRI	IRI	NNP
cord-003921-8r8z0otz	94	41	in	in	IN
cord-003921-8r8z0otz	94	42	methionine	methionine	NN
cord-003921-8r8z0otz	94	43	/	/	SYM
cord-003921-8r8z0otz	94	44	choline	choline	NN
cord-003921-8r8z0otz	94	45	-	-	HYPH
cord-003921-8r8z0otz	94	46	deficient	deficient	JJ
cord-003921-8r8z0otz	94	47	diet	diet	NN
cord-003921-8r8z0otz	94	48	conditioned	condition	VBN
cord-003921-8r8z0otz	94	49	rats	rat	NNS
cord-003921-8r8z0otz	94	50	[	[	-LRB-
cord-003921-8r8z0otz	94	51	45	45	CD
cord-003921-8r8z0otz	94	52	]	]	-RRB-
cord-003921-8r8z0otz	94	53	.	.	.
cord-003921-8r8z0otz	95	1	Meanwhile	meanwhile	RB
cord-003921-8r8z0otz	95	2	,	,	,
cord-003921-8r8z0otz	95	3	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	95	4	contain	contain	VBP
cord-003921-8r8z0otz	95	5	large	large	JJ
cord-003921-8r8z0otz	95	6	quantities	quantity	NNS
cord-003921-8r8z0otz	95	7	of	of	IN
cord-003921-8r8z0otz	95	8	serine	serine	NN
cord-003921-8r8z0otz	95	9	proteases	protease	NNS
cord-003921-8r8z0otz	95	10	in	in	IN
cord-003921-8r8z0otz	95	11	the	the	DT
cord-003921-8r8z0otz	95	12	azurophilic	azurophilic	JJ
cord-003921-8r8z0otz	95	13	granules	granule	NNS
cord-003921-8r8z0otz	95	14	,	,	,
cord-003921-8r8z0otz	95	15	such	such	JJ
cord-003921-8r8z0otz	95	16	as	as	IN
cord-003921-8r8z0otz	95	17	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	95	18	elastase	elastase	NN
cord-003921-8r8z0otz	95	19	,	,	,
cord-003921-8r8z0otz	95	20	proteinase	proteinase	NN
cord-003921-8r8z0otz	95	21	3	3	CD
cord-003921-8r8z0otz	95	22	,	,	,
cord-003921-8r8z0otz	95	23	and	and	CC
cord-003921-8r8z0otz	95	24	cathepsin	cathepsin	NN
cord-003921-8r8z0otz	95	25	G.	G.	NNP
cord-003921-8r8z0otz	96	1	After	after	IN
cord-003921-8r8z0otz	96	2	arriving	arrive	VBG
cord-003921-8r8z0otz	96	3	at	at	IN
cord-003921-8r8z0otz	96	4	the	the	DT
cord-003921-8r8z0otz	96	5	damaged	damage	VBN
cord-003921-8r8z0otz	96	6	site	site	NN
cord-003921-8r8z0otz	96	7	,	,	,
cord-003921-8r8z0otz	96	8	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	96	9	degranulate	degranulate	NNP
cord-003921-8r8z0otz	96	10	and	and	CC
cord-003921-8r8z0otz	96	11	release	release	VB
cord-003921-8r8z0otz	96	12	them	-PRON-	PRP
cord-003921-8r8z0otz	96	13	to	to	TO
cord-003921-8r8z0otz	96	14	exert	exert	VB
cord-003921-8r8z0otz	96	15	,	,	,
cord-003921-8r8z0otz	96	16	in	in	IN
cord-003921-8r8z0otz	96	17	combination	combination	NN
cord-003921-8r8z0otz	96	18	with	with	IN
cord-003921-8r8z0otz	96	19	ROS	ROS	NNP
cord-003921-8r8z0otz	96	20	,	,	,
cord-003921-8r8z0otz	96	21	their	-PRON-	PRP$
cord-003921-8r8z0otz	96	22	effector	effector	NN
cord-003921-8r8z0otz	96	23	functions	function	NNS
cord-003921-8r8z0otz	96	24	.	.	.
cord-003921-8r8z0otz	97	1	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	97	2	elastase	elastase	NN
cord-003921-8r8z0otz	97	3	,	,	,
cord-003921-8r8z0otz	97	4	a	a	DT
cord-003921-8r8z0otz	97	5	29	29	CD
cord-003921-8r8z0otz	97	6	kDa	kDa	NNP
cord-003921-8r8z0otz	97	7	chymotrypsin	chymotrypsin	NNP
cord-003921-8r8z0otz	97	8	-	-	HYPH
cord-003921-8r8z0otz	97	9	like	like	JJ
cord-003921-8r8z0otz	97	10	serine	serine	NN
cord-003921-8r8z0otz	97	11	protease	protease	NN
cord-003921-8r8z0otz	97	12	which	which	WDT
cord-003921-8r8z0otz	97	13	degrades	degrade	VBZ
cord-003921-8r8z0otz	97	14	ECMs	ECMs	NNP
cord-003921-8r8z0otz	97	15	causes	cause	VBZ
cord-003921-8r8z0otz	97	16	organ	organ	NN
cord-003921-8r8z0otz	97	17	damage	damage	NN
cord-003921-8r8z0otz	97	18	,	,	,
cord-003921-8r8z0otz	97	19	whereas	whereas	IN
cord-003921-8r8z0otz	97	20	sivelestat	sivelestat	NNP
cord-003921-8r8z0otz	97	21	(	(	-LRB-
cord-003921-8r8z0otz	97	22	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	97	23	elastase	elastase	NN
cord-003921-8r8z0otz	97	24	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	97	25	)	)	-RRB-
cord-003921-8r8z0otz	97	26	is	be	VBZ
cord-003921-8r8z0otz	97	27	widely	widely	RB
cord-003921-8r8z0otz	97	28	used	use	VBN
cord-003921-8r8z0otz	97	29	in	in	IN
cord-003921-8r8z0otz	97	30	treating	treat	VBG
cord-003921-8r8z0otz	97	31	acute	acute	JJ
cord-003921-8r8z0otz	97	32	lung	lung	NN
cord-003921-8r8z0otz	97	33	injury	injury	NN
cord-003921-8r8z0otz	97	34	in	in	IN
cord-003921-8r8z0otz	97	35	humans	human	NNS
cord-003921-8r8z0otz	97	36	.	.	.
cord-003921-8r8z0otz	98	1	We	-PRON-	PRP
cord-003921-8r8z0otz	98	2	and	and	CC
cord-003921-8r8z0otz	98	3	others	other	NNS
cord-003921-8r8z0otz	98	4	have	have	VBP
cord-003921-8r8z0otz	98	5	reported	report	VBN
cord-003921-8r8z0otz	98	6	that	that	IN
cord-003921-8r8z0otz	98	7	sivelestat	sivelestat	NNP
cord-003921-8r8z0otz	98	8	inhibited	inhibited	JJ
cord-003921-8r8z0otz	98	9	adhesion	adhesion	NN
cord-003921-8r8z0otz	98	10	and	and	CC
cord-003921-8r8z0otz	98	11	migration	migration	NN
cord-003921-8r8z0otz	98	12	of	of	IN
cord-003921-8r8z0otz	98	13	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	98	14	to	to	IN
cord-003921-8r8z0otz	98	15	vascular	vascular	JJ
cord-003921-8r8z0otz	98	16	endothelium	endothelium	NN
cord-003921-8r8z0otz	98	17	and	and	CC
cord-003921-8r8z0otz	98	18	protected	protect	VBN
cord-003921-8r8z0otz	98	19	mouse	mouse	NN
cord-003921-8r8z0otz	98	20	livers	liver	NNS
cord-003921-8r8z0otz	98	21	against	against	IN
cord-003921-8r8z0otz	98	22	IRI	IRI	NNP
cord-003921-8r8z0otz	98	23	[	[	-LRB-
cord-003921-8r8z0otz	98	24	46	46	CD
cord-003921-8r8z0otz	98	25	,	,	,
cord-003921-8r8z0otz	98	26	47	47	CD
cord-003921-8r8z0otz	98	27	]	]	-RRB-
cord-003921-8r8z0otz	98	28	.	.	.
cord-003921-8r8z0otz	99	1	Furthermore	furthermore	RB
cord-003921-8r8z0otz	99	2	,	,	,
cord-003921-8r8z0otz	99	3	a	a	DT
cord-003921-8r8z0otz	99	4	randomized	randomized	JJ
cord-003921-8r8z0otz	99	5	clinical	clinical	JJ
cord-003921-8r8z0otz	99	6	study	study	NN
cord-003921-8r8z0otz	99	7	in	in	IN
cord-003921-8r8z0otz	99	8	patients	patient	NNS
cord-003921-8r8z0otz	99	9	that	that	IN
cord-003921-8r8z0otz	99	10	underwent	undergo	VBD
cord-003921-8r8z0otz	99	11	hepatic	hepatic	JJ
cord-003921-8r8z0otz	99	12	resection	resection	NN
cord-003921-8r8z0otz	99	13	revealed	reveal	VBD
cord-003921-8r8z0otz	99	14	sivelestat	sivelestat	JJ
cord-003921-8r8z0otz	99	15	treatment	treatment	NN
cord-003921-8r8z0otz	99	16	reduced	reduce	VBN
cord-003921-8r8z0otz	99	17	post	post	JJ
cord-003921-8r8z0otz	99	18	-	-	JJ
cord-003921-8r8z0otz	99	19	operative	operative	JJ
cord-003921-8r8z0otz	99	20	serum	serum	NN
cord-003921-8r8z0otz	99	21	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	100	1	and	and	CC
cord-003921-8r8z0otz	100	2	IL6	il6	NN
cord-003921-8r8z0otz	100	3	levels	level	NNS
cord-003921-8r8z0otz	100	4	[	[	-LRB-
cord-003921-8r8z0otz	100	5	48	48	CD
cord-003921-8r8z0otz	100	6	]	]	-RRB-
cord-003921-8r8z0otz	100	7	.	.	.
cord-003921-8r8z0otz	101	1	Myeloperoxidase	Myeloperoxidase	NNP
cord-003921-8r8z0otz	101	2	(	(	-LRB-
cord-003921-8r8z0otz	101	3	MPO	MPO	NNP
cord-003921-8r8z0otz	101	4	)	)	-RRB-
cord-003921-8r8z0otz	101	5	,	,	,
cord-003921-8r8z0otz	101	6	a	a	DT
cord-003921-8r8z0otz	101	7	heme	heme	NN
cord-003921-8r8z0otz	101	8	protein	protein	NN
cord-003921-8r8z0otz	101	9	synthesized	synthesize	VBN
cord-003921-8r8z0otz	101	10	during	during	IN
cord-003921-8r8z0otz	101	11	myeloid	myeloid	JJ
cord-003921-8r8z0otz	101	12	differentiation	differentiation	NN
cord-003921-8r8z0otz	101	13	,	,	,
cord-003921-8r8z0otz	101	14	is	be	VBZ
cord-003921-8r8z0otz	101	15	often	often	RB
cord-003921-8r8z0otz	101	16	used	use	VBN
cord-003921-8r8z0otz	101	17	as	as	IN
cord-003921-8r8z0otz	101	18	a	a	DT
cord-003921-8r8z0otz	101	19	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	101	20	activity	activity	NN
cord-003921-8r8z0otz	101	21	marker	marker	NN
cord-003921-8r8z0otz	101	22	.	.	.
cord-003921-8r8z0otz	102	1	In	in	IN
cord-003921-8r8z0otz	102	2	the	the	DT
cord-003921-8r8z0otz	102	3	presence	presence	NN
cord-003921-8r8z0otz	102	4	of	of	IN
cord-003921-8r8z0otz	102	5	physiological	physiological	JJ
cord-003921-8r8z0otz	102	6	chloride	chloride	NN
cord-003921-8r8z0otz	102	7	concentrations	concentration	NNS
cord-003921-8r8z0otz	102	8	,	,	,
cord-003921-8r8z0otz	102	9	MPO	MPO	NNP
cord-003921-8r8z0otz	102	10	reacts	react	VBZ
cord-003921-8r8z0otz	102	11	with	with	IN
cord-003921-8r8z0otz	102	12	hydrogen	hydrogen	NN
cord-003921-8r8z0otz	102	13	peroxide	peroxide	NN
cord-003921-8r8z0otz	102	14	to	to	TO
cord-003921-8r8z0otz	102	15	catalyze	catalyze	VB
cord-003921-8r8z0otz	102	16	formation	formation	NN
cord-003921-8r8z0otz	102	17	of	of	IN
cord-003921-8r8z0otz	102	18	hypochlorous	hypochlorous	JJ
cord-003921-8r8z0otz	102	19	acid	acid	NN
cord-003921-8r8z0otz	102	20	/	/	SYM
cord-003921-8r8z0otz	102	21	hypochlorite	hypochlorite	NN
cord-003921-8r8z0otz	102	22	and	and	CC
cord-003921-8r8z0otz	102	23	other	other	JJ
cord-003921-8r8z0otz	102	24	oxidizing	oxidize	VBG
cord-003921-8r8z0otz	102	25	species	specie	NNS
cord-003921-8r8z0otz	102	26	[	[	-LRB-
cord-003921-8r8z0otz	102	27	49	49	CD
cord-003921-8r8z0otz	102	28	]	]	-RRB-
cord-003921-8r8z0otz	102	29	,	,	,
cord-003921-8r8z0otz	102	30	and	and	CC
cord-003921-8r8z0otz	102	31	thus	thus	RB
cord-003921-8r8z0otz	102	32	,	,	,
cord-003921-8r8z0otz	102	33	it	-PRON-	PRP
cord-003921-8r8z0otz	102	34	is	be	VBZ
cord-003921-8r8z0otz	102	35	also	also	RB
cord-003921-8r8z0otz	102	36	considered	consider	VBN
cord-003921-8r8z0otz	102	37	as	as	IN
cord-003921-8r8z0otz	102	38	a	a	DT
cord-003921-8r8z0otz	102	39	cytotoxic	cytotoxic	JJ
cord-003921-8r8z0otz	102	40	molecule	molecule	NN
cord-003921-8r8z0otz	102	41	in	in	IN
cord-003921-8r8z0otz	102	42	liver	liver	NN
cord-003921-8r8z0otz	102	43	pathophysiology	pathophysiology	NN
cord-003921-8r8z0otz	102	44	.	.	.
cord-003921-8r8z0otz	103	1	However	however	RB
cord-003921-8r8z0otz	103	2	,	,	,
cord-003921-8r8z0otz	103	3	its	-PRON-	PRP$
cord-003921-8r8z0otz	103	4	cytotoxicity	cytotoxicity	NN
cord-003921-8r8z0otz	103	5	in	in	IN
cord-003921-8r8z0otz	103	6	liver	liver	NN
cord-003921-8r8z0otz	103	7	IRI	IRI	NNP
cord-003921-8r8z0otz	103	8	remains	remain	VBZ
cord-003921-8r8z0otz	103	9	to	to	TO
cord-003921-8r8z0otz	103	10	be	be	VB
cord-003921-8r8z0otz	103	11	rigorously	rigorously	RB
cord-003921-8r8z0otz	103	12	re	re	VBN
cord-003921-8r8z0otz	103	13	-	-	VBN
cord-003921-8r8z0otz	103	14	evaluated	evaluate	VBN
cord-003921-8r8z0otz	103	15	as	as	IN
cord-003921-8r8z0otz	103	16	a	a	DT
cord-003921-8r8z0otz	103	17	recent	recent	JJ
cord-003921-8r8z0otz	103	18	study	study	NN
cord-003921-8r8z0otz	104	1	demonstrated	demonstrate	VBD
cord-003921-8r8z0otz	104	2	MPO	MPO	NNP
cord-003921-8r8z0otz	104	3	was	be	VBD
cord-003921-8r8z0otz	104	4	required	require	VBN
cord-003921-8r8z0otz	104	5	for	for	IN
cord-003921-8r8z0otz	104	6	hepatoprotection	hepatoprotection	NN
cord-003921-8r8z0otz	104	7	in	in	IN
cord-003921-8r8z0otz	104	8	endotoxin	endotoxin	NN
cord-003921-8r8z0otz	104	9	-	-	HYPH
cord-003921-8r8z0otz	104	10	induced	induce	VBN
cord-003921-8r8z0otz	104	11	inflammation	inflammation	NN
cord-003921-8r8z0otz	104	12	[	[	-LRB-
cord-003921-8r8z0otz	104	13	50•	50•	CD
cord-003921-8r8z0otz	104	14	]	]	-RRB-
cord-003921-8r8z0otz	104	15	.	.	.
cord-003921-8r8z0otz	105	1	With	with	IN
cord-003921-8r8z0otz	105	2	recent	recent	JJ
cord-003921-8r8z0otz	105	3	data	datum	NNS
cord-003921-8r8z0otz	105	4	showing	show	VBG
cord-003921-8r8z0otz	105	5	efficacy	efficacy	NN
cord-003921-8r8z0otz	105	6	and	and	CC
cord-003921-8r8z0otz	105	7	tolerability	tolerability	NN
cord-003921-8r8z0otz	105	8	of	of	IN
cord-003921-8r8z0otz	105	9	AZD3241	AZD3241	NNP
cord-003921-8r8z0otz	105	10	(	(	-LRB-
cord-003921-8r8z0otz	105	11	an	an	DT
cord-003921-8r8z0otz	105	12	orally	orally	RB
cord-003921-8r8z0otz	105	13	absorbed	absorb	VBN
cord-003921-8r8z0otz	105	14	irreversible	irreversible	JJ
cord-003921-8r8z0otz	105	15	human	human	JJ
cord-003921-8r8z0otz	105	16	MPO	MPO	NNP
cord-003921-8r8z0otz	105	17	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	105	18	)	)	-RRB-
cord-003921-8r8z0otz	105	19	in	in	IN
cord-003921-8r8z0otz	105	20	Parkinson	Parkinson	NNP
cord-003921-8r8z0otz	105	21	patients	patient	NNS
cord-003921-8r8z0otz	105	22	[	[	-LRB-
cord-003921-8r8z0otz	105	23	51	51	CD
cord-003921-8r8z0otz	105	24	]	]	-RRB-
cord-003921-8r8z0otz	105	25	,	,	,
cord-003921-8r8z0otz	105	26	the	the	DT
cord-003921-8r8z0otz	105	27	thorough	thorough	JJ
cord-003921-8r8z0otz	105	28	evaluation	evaluation	NN
cord-003921-8r8z0otz	105	29	of	of	IN
cord-003921-8r8z0otz	105	30	MPO	MPO	NNP
cord-003921-8r8z0otz	105	31	in	in	IN
cord-003921-8r8z0otz	105	32	liver	liver	NN
cord-003921-8r8z0otz	105	33	LT	LT	NNP
cord-003921-8r8z0otz	105	34	settings	setting	NNS
cord-003921-8r8z0otz	105	35	seems	seem	VBZ
cord-003921-8r8z0otz	105	36	warranted	warrant	VBN
cord-003921-8r8z0otz	105	37	.	.	.
cord-003921-8r8z0otz	106	1	Activated	activate	VBN
cord-003921-8r8z0otz	106	2	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	106	3	can	can	MD
cord-003921-8r8z0otz	106	4	enhance	enhance	VB
cord-003921-8r8z0otz	106	5	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	106	6	tissue	tissue	NN
cord-003921-8r8z0otz	106	7	damage	damage	NN
cord-003921-8r8z0otz	106	8	by	by	IN
cord-003921-8r8z0otz	106	9	releasing	release	VBG
cord-003921-8r8z0otz	106	10	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	106	11	extracellular	extracellular	JJ
cord-003921-8r8z0otz	106	12	traps	trap	NNS
cord-003921-8r8z0otz	106	13	(	(	-LRB-
cord-003921-8r8z0otz	106	14	NETs	NETs	NNP
cord-003921-8r8z0otz	106	15	)	)	-RRB-
cord-003921-8r8z0otz	106	16	,	,	,
cord-003921-8r8z0otz	106	17	i.e.	i.e.	FW
cord-003921-8r8z0otz	106	18	,	,	,
cord-003921-8r8z0otz	106	19	extracellular	extracellular	JJ
cord-003921-8r8z0otz	106	20	scaffolds	scaffold	NNS
cord-003921-8r8z0otz	106	21	of	of	IN
cord-003921-8r8z0otz	106	22	DNA	dna	NN
cord-003921-8r8z0otz	106	23	fibers	fiber	NNS
cord-003921-8r8z0otz	106	24	decorated	decorate	VBN
cord-003921-8r8z0otz	106	25	with	with	IN
cord-003921-8r8z0otz	106	26	histone	histone	NN
cord-003921-8r8z0otz	106	27	,	,	,
cord-003921-8r8z0otz	106	28	granule	granule	NN
cord-003921-8r8z0otz	106	29	-	-	HYPH
cord-003921-8r8z0otz	106	30	derived	derive	VBN
cord-003921-8r8z0otz	106	31	antimicrobial	antimicrobial	JJ
cord-003921-8r8z0otz	106	32	peptides	peptide	NNS
cord-003921-8r8z0otz	106	33	,	,	,
cord-003921-8r8z0otz	106	34	and	and	CC
cord-003921-8r8z0otz	106	35	enzymes	enzyme	NNS
cord-003921-8r8z0otz	106	36	,	,	,
cord-003921-8r8z0otz	106	37	such	such	JJ
cord-003921-8r8z0otz	106	38	as	as	IN
cord-003921-8r8z0otz	106	39	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	106	40	erastase	erastase	NN
cord-003921-8r8z0otz	106	41	,	,	,
cord-003921-8r8z0otz	106	42	cathepsin	cathepsin	NN
cord-003921-8r8z0otz	106	43	G	g	NN
cord-003921-8r8z0otz	106	44	,	,	,
cord-003921-8r8z0otz	106	45	and	and	CC
cord-003921-8r8z0otz	106	46	MPO	MPO	NNP
cord-003921-8r8z0otz	106	47	[	[	-LRB-
cord-003921-8r8z0otz	106	48	52	52	CD
cord-003921-8r8z0otz	106	49	]	]	-RRB-
cord-003921-8r8z0otz	106	50	.	.	.
cord-003921-8r8z0otz	107	1	Generation	generation	NN
cord-003921-8r8z0otz	107	2	of	of	IN
cord-003921-8r8z0otz	107	3	ROS	ROS	NNP
cord-003921-8r8z0otz	107	4	by	by	IN
cord-003921-8r8z0otz	107	5	NADPH	NADPH	NNP
cord-003921-8r8z0otz	107	6	oxidase	oxidase	NN
cord-003921-8r8z0otz	107	7	and	and	CC
cord-003921-8r8z0otz	107	8	activation	activation	NN
cord-003921-8r8z0otz	107	9	of	of	IN
cord-003921-8r8z0otz	107	10	protein	protein	NN
cord-003921-8r8z0otz	107	11	-	-	HYPH
cord-003921-8r8z0otz	107	12	arginine	arginine	NN
cord-003921-8r8z0otz	107	13	deiminase	deiminase	NN
cord-003921-8r8z0otz	107	14	4	4	CD
cord-003921-8r8z0otz	107	15	(	(	-LRB-
cord-003921-8r8z0otz	107	16	PAD4	PAD4	NNP
cord-003921-8r8z0otz	107	17	)	)	-RRB-
cord-003921-8r8z0otz	107	18	,	,	,
cord-003921-8r8z0otz	107	19	an	an	DT
cord-003921-8r8z0otz	107	20	enzyme	enzyme	NN
cord-003921-8r8z0otz	107	21	that	that	WDT
cord-003921-8r8z0otz	107	22	converts	convert	VBZ
cord-003921-8r8z0otz	107	23	arginine	arginine	NN
cord-003921-8r8z0otz	107	24	to	to	IN
cord-003921-8r8z0otz	107	25	citrulline	citrulline	NN
cord-003921-8r8z0otz	107	26	on	on	IN
cord-003921-8r8z0otz	107	27	histones	histone	NNS
cord-003921-8r8z0otz	107	28	,	,	,
cord-003921-8r8z0otz	107	29	are	be	VBP
cord-003921-8r8z0otz	107	30	essential	essential	JJ
cord-003921-8r8z0otz	107	31	steps	step	NNS
cord-003921-8r8z0otz	107	32	for	for	IN
cord-003921-8r8z0otz	107	33	chromatin	chromatin	NN
cord-003921-8r8z0otz	107	34	decondensation	decondensation	NN
cord-003921-8r8z0otz	107	35	in	in	IN
cord-003921-8r8z0otz	107	36	the	the	DT
cord-003921-8r8z0otz	107	37	NET	net	JJ
cord-003921-8r8z0otz	107	38	formation	formation	NN
cord-003921-8r8z0otz	107	39	.	.	.
cord-003921-8r8z0otz	108	1	NE	NE	NNP
cord-003921-8r8z0otz	108	2	and	and	CC
cord-003921-8r8z0otz	108	3	MPO	MPO	NNP
cord-003921-8r8z0otz	108	4	translocated	translocate	VBD
cord-003921-8r8z0otz	108	5	into	into	IN
cord-003921-8r8z0otz	108	6	the	the	DT
cord-003921-8r8z0otz	108	7	nucleus	nucleus	NN
cord-003921-8r8z0otz	108	8	further	further	RB
cord-003921-8r8z0otz	108	9	unfold	unfold	NN
cord-003921-8r8z0otz	108	10	chromatin	chromatin	NN
cord-003921-8r8z0otz	108	11	,	,	,
cord-003921-8r8z0otz	108	12	leading	lead	VBG
cord-003921-8r8z0otz	108	13	to	to	IN
cord-003921-8r8z0otz	108	14	the	the	DT
cord-003921-8r8z0otz	108	15	nuclear	nuclear	JJ
cord-003921-8r8z0otz	108	16	membrane	membrane	NN
cord-003921-8r8z0otz	108	17	break	break	NN
cord-003921-8r8z0otz	108	18	,	,	,
cord-003921-8r8z0otz	108	19	chromatin	chromatin	NN
cord-003921-8r8z0otz	108	20	release	release	NN
cord-003921-8r8z0otz	108	21	into	into	IN
cord-003921-8r8z0otz	108	22	cytosol	cytosol	NN
cord-003921-8r8z0otz	108	23	where	where	WRB
cord-003921-8r8z0otz	108	24	it	-PRON-	PRP
cord-003921-8r8z0otz	108	25	is	be	VBZ
cord-003921-8r8z0otz	108	26	further	further	RB
cord-003921-8r8z0otz	108	27	decorated	decorate	VBN
cord-003921-8r8z0otz	108	28	with	with	IN
cord-003921-8r8z0otz	108	29	granular	granular	JJ
cord-003921-8r8z0otz	108	30	and	and	CC
cord-003921-8r8z0otz	108	31	cytosolic	cytosolic	JJ
cord-003921-8r8z0otz	108	32	proteins	protein	NNS
cord-003921-8r8z0otz	108	33	,	,	,
cord-003921-8r8z0otz	108	34	and	and	CC
cord-003921-8r8z0otz	108	35	the	the	DT
cord-003921-8r8z0otz	108	36	emission	emission	NN
cord-003921-8r8z0otz	108	37	of	of	IN
cord-003921-8r8z0otz	108	38	these	these	DT
cord-003921-8r8z0otz	108	39	traps	trap	NNS
cord-003921-8r8z0otz	108	40	into	into	IN
cord-003921-8r8z0otz	108	41	extracellular	extracellular	JJ
cord-003921-8r8z0otz	108	42	space	space	NN
cord-003921-8r8z0otz	108	43	[	[	-LRB-
cord-003921-8r8z0otz	108	44	53	53	CD
cord-003921-8r8z0otz	108	45	]	]	-RRB-
cord-003921-8r8z0otz	108	46	.	.	.
cord-003921-8r8z0otz	109	1	NETs	net	NNS
cord-003921-8r8z0otz	109	2	function	function	NN
cord-003921-8r8z0otz	109	3	was	be	VBD
cord-003921-8r8z0otz	109	4	originally	originally	RB
cord-003921-8r8z0otz	109	5	described	describe	VBN
cord-003921-8r8z0otz	109	6	as	as	IN
cord-003921-8r8z0otz	109	7	the	the	DT
cord-003921-8r8z0otz	109	8	efficient	efficient	JJ
cord-003921-8r8z0otz	109	9	means	mean	NNS
cord-003921-8r8z0otz	109	10	to	to	TO
cord-003921-8r8z0otz	109	11	immobilize	immobilize	VB
cord-003921-8r8z0otz	109	12	,	,	,
cord-003921-8r8z0otz	109	13	catch	catch	VB
cord-003921-8r8z0otz	109	14	,	,	,
cord-003921-8r8z0otz	109	15	and	and	CC
cord-003921-8r8z0otz	109	16	eliminate	eliminate	VB
cord-003921-8r8z0otz	109	17	pathogens	pathogen	NNS
cord-003921-8r8z0otz	109	18	,	,	,
cord-003921-8r8z0otz	109	19	whereas	whereas	IN
cord-003921-8r8z0otz	109	20	recent	recent	JJ
cord-003921-8r8z0otz	109	21	studies	study	NNS
cord-003921-8r8z0otz	109	22	have	have	VBP
cord-003921-8r8z0otz	109	23	recognized	recognize	VBN
cord-003921-8r8z0otz	109	24	its	-PRON-	PRP$
cord-003921-8r8z0otz	109	25	critical	critical	JJ
cord-003921-8r8z0otz	109	26	involvement	involvement	NN
cord-003921-8r8z0otz	109	27	in	in	IN
cord-003921-8r8z0otz	109	28	noninfectious	noninfectious	JJ
cord-003921-8r8z0otz	109	29	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	109	30	states	state	NNS
cord-003921-8r8z0otz	109	31	,	,	,
cord-003921-8r8z0otz	109	32	including	include	VBG
cord-003921-8r8z0otz	109	33	IR	ir	NN
cord-003921-8r8z0otz	109	34	-	-	HYPH
cord-003921-8r8z0otz	109	35	stress	stress	NN
cord-003921-8r8z0otz	109	36	.	.	.
cord-003921-8r8z0otz	110	1	Indeed	indeed	RB
cord-003921-8r8z0otz	110	2	,	,	,
cord-003921-8r8z0otz	110	3	biopsies	biopsy	NNS
cord-003921-8r8z0otz	110	4	obtained	obtain	VBN
cord-003921-8r8z0otz	110	5	from	from	IN
cord-003921-8r8z0otz	110	6	human	human	JJ
cord-003921-8r8z0otz	110	7	kidney	kidney	NN
cord-003921-8r8z0otz	110	8	transplant	transplant	NN
cord-003921-8r8z0otz	110	9	recipients	recipient	NNS
cord-003921-8r8z0otz	110	10	with	with	IN
cord-003921-8r8z0otz	110	11	post	post	JJ
cord-003921-8r8z0otz	110	12	-	-	JJ
cord-003921-8r8z0otz	110	13	transplant	transplant	JJ
cord-003921-8r8z0otz	110	14	acute	acute	JJ
cord-003921-8r8z0otz	110	15	tubular	tubular	JJ
cord-003921-8r8z0otz	110	16	necrosis	necrosis	NN
cord-003921-8r8z0otz	110	17	exhibited	exhibit	VBD
cord-003921-8r8z0otz	110	18	increased	increase	VBN
cord-003921-8r8z0otz	110	19	NETs	NETs	NNP
cord-003921-8r8z0otz	110	20	formation	formation	NN
cord-003921-8r8z0otz	110	21	[	[	-LRB-
cord-003921-8r8z0otz	110	22	54•	54•	CD
cord-003921-8r8z0otz	110	23	]	]	-RRB-
cord-003921-8r8z0otz	110	24	,	,	,
cord-003921-8r8z0otz	110	25	while	while	IN
cord-003921-8r8z0otz	110	26	bronchoalveolar	bronchoalveolar	NNP
cord-003921-8r8z0otz	110	27	lavage	lavage	NNP
cord-003921-8r8z0otz	110	28	fluid	fluid	NN
cord-003921-8r8z0otz	110	29	collected	collect	VBN
cord-003921-8r8z0otz	110	30	from	from	IN
cord-003921-8r8z0otz	110	31	human	human	JJ
cord-003921-8r8z0otz	110	32	lung	lung	NN
cord-003921-8r8z0otz	110	33	transplant	transplant	NN
cord-003921-8r8z0otz	110	34	recipients	recipient	NNS
cord-003921-8r8z0otz	110	35	with	with	IN
cord-003921-8r8z0otz	110	36	primary	primary	JJ
cord-003921-8r8z0otz	110	37	graft	graft	NN
cord-003921-8r8z0otz	110	38	dysfunction	dysfunction	NN
cord-003921-8r8z0otz	110	39	contained	contain	VBD
cord-003921-8r8z0otz	110	40	extensive	extensive	JJ
cord-003921-8r8z0otz	110	41	NETs	net	NNS
cord-003921-8r8z0otz	110	42	[	[	-LRB-
cord-003921-8r8z0otz	110	43	55	55	CD
cord-003921-8r8z0otz	110	44	]	]	-RRB-
cord-003921-8r8z0otz	110	45	.	.	.
cord-003921-8r8z0otz	111	1	Furthermore	furthermore	RB
cord-003921-8r8z0otz	111	2	,	,	,
cord-003921-8r8z0otz	111	3	several	several	JJ
cord-003921-8r8z0otz	111	4	NET	net	NN
cord-003921-8r8z0otz	111	5	-	-	HYPH
cord-003921-8r8z0otz	111	6	targeting	target	VBG
cord-003921-8r8z0otz	111	7	agents	agent	NNS
cord-003921-8r8z0otz	111	8	successfully	successfully	RB
cord-003921-8r8z0otz	111	9	attenuated	attenuate	VBD
cord-003921-8r8z0otz	111	10	IRI	IRI	NNP
cord-003921-8r8z0otz	111	11	in	in	IN
cord-003921-8r8z0otz	111	12	murine	murine	JJ
cord-003921-8r8z0otz	111	13	models	model	NNS
cord-003921-8r8z0otz	111	14	,	,	,
cord-003921-8r8z0otz	111	15	including	include	VBG
cord-003921-8r8z0otz	111	16	PAD4	PAD4	NNP
cord-003921-8r8z0otz	111	17	inhibitors	inhibitor	NNS
cord-003921-8r8z0otz	111	18	(	(	-LRB-
cord-003921-8r8z0otz	111	19	YW3	yw3	NN
cord-003921-8r8z0otz	111	20	-	-	HYPH
cord-003921-8r8z0otz	111	21	56	56	CD
cord-003921-8r8z0otz	111	22	,	,	,
cord-003921-8r8z0otz	111	23	YW4	YW4	NNP
cord-003921-8r8z0otz	111	24	-	-	HYPH
cord-003921-8r8z0otz	111	25	03	03	NNP
cord-003921-8r8z0otz	111	26	)	)	-RRB-
cord-003921-8r8z0otz	111	27	,	,	,
cord-003921-8r8z0otz	111	28	which	which	WDT
cord-003921-8r8z0otz	111	29	reduced	reduce	VBD
cord-003921-8r8z0otz	111	30	NETs	net	NNS
cord-003921-8r8z0otz	111	31	formation	formation	NN
cord-003921-8r8z0otz	111	32	and	and	CC
cord-003921-8r8z0otz	111	33	decreased	decrease	VBD
cord-003921-8r8z0otz	111	34	severity	severity	NN
cord-003921-8r8z0otz	111	35	of	of	IN
cord-003921-8r8z0otz	111	36	liver	liver	NN
cord-003921-8r8z0otz	111	37	IRI	IRI	NNP
cord-003921-8r8z0otz	111	38	[	[	-LRB-
cord-003921-8r8z0otz	111	39	56•	56•	NNP
cord-003921-8r8z0otz	111	40	]	]	-RRB-
cord-003921-8r8z0otz	111	41	;	;	:
cord-003921-8r8z0otz	111	42	PAD	pad	NN
cord-003921-8r8z0otz	111	43	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	111	44	(	(	-LRB-
cord-003921-8r8z0otz	111	45	Clamidine	Clamidine	NNP
cord-003921-8r8z0otz	111	46	)	)	-RRB-
cord-003921-8r8z0otz	111	47	,	,	,
cord-003921-8r8z0otz	111	48	which	which	WDT
cord-003921-8r8z0otz	111	49	suppressed	suppress	VBD
cord-003921-8r8z0otz	111	50	NETs	net	NNS
cord-003921-8r8z0otz	111	51	and	and	CC
cord-003921-8r8z0otz	111	52	alleviated	alleviate	VBD
cord-003921-8r8z0otz	111	53	renal	renal	JJ
cord-003921-8r8z0otz	111	54	IRI	IRI	NNP
cord-003921-8r8z0otz	111	55	[	[	-LRB-
cord-003921-8r8z0otz	111	56	54•	54•	CD
cord-003921-8r8z0otz	111	57	]	]	-RRB-
cord-003921-8r8z0otz	111	58	;	;	:
cord-003921-8r8z0otz	111	59	or	or	CC
cord-003921-8r8z0otz	111	60	DNase	DNase	NNP
cord-003921-8r8z0otz	111	61	I	-PRON-	PRP
cord-003921-8r8z0otz	111	62	combined	combine	VBN
cord-003921-8r8z0otz	111	63	with	with	IN
cord-003921-8r8z0otz	111	64	recombinant	recombinant	JJ
cord-003921-8r8z0otz	111	65	tissue	tissue	NN
cord-003921-8r8z0otz	111	66	-	-	HYPH
cord-003921-8r8z0otz	111	67	type	type	NN
cord-003921-8r8z0otz	111	68	plasminogen	plasminogen	NN
cord-003921-8r8z0otz	111	69	activator	activator	NN
cord-003921-8r8z0otz	111	70	,	,	,
cord-003921-8r8z0otz	111	71	which	which	WDT
cord-003921-8r8z0otz	111	72	inhibited	inhibit	VBD
cord-003921-8r8z0otz	111	73	NETs	net	NNS
cord-003921-8r8z0otz	111	74	and	and	CC
cord-003921-8r8z0otz	111	75	alleviated	alleviate	VBD
cord-003921-8r8z0otz	111	76	myocardial	myocardial	JJ
cord-003921-8r8z0otz	111	77	IRI	IRI	NNP
cord-003921-8r8z0otz	111	78	[	[	-LRB-
cord-003921-8r8z0otz	111	79	57	57	CD
cord-003921-8r8z0otz	111	80	]	]	-RRB-
cord-003921-8r8z0otz	111	81	.	.	.
cord-003921-8r8z0otz	112	1	Additional	additional	JJ
cord-003921-8r8z0otz	112	2	functional	functional	JJ
cord-003921-8r8z0otz	112	3	aspects	aspect	NNS
cord-003921-8r8z0otz	112	4	of	of	IN
cord-003921-8r8z0otz	112	5	NETs	net	NNS
cord-003921-8r8z0otz	112	6	are	be	VBP
cord-003921-8r8z0otz	112	7	detailed	detail	VBN
cord-003921-8r8z0otz	112	8	below	below	RB
cord-003921-8r8z0otz	112	9	.	.	.
cord-003921-8r8z0otz	113	1	In	in	IN
cord-003921-8r8z0otz	113	2	addition	addition	NN
cord-003921-8r8z0otz	113	3	to	to	IN
cord-003921-8r8z0otz	113	4	pro	pro	JJ
cord-003921-8r8z0otz	113	5	-	-	JJ
cord-003921-8r8z0otz	113	6	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	113	7	and	and	CC
cord-003921-8r8z0otz	113	8	tissue	tissue	NN
cord-003921-8r8z0otz	113	9	-	-	HYPH
cord-003921-8r8z0otz	113	10	destructive	destructive	JJ
cord-003921-8r8z0otz	113	11	functions	function	NNS
cord-003921-8r8z0otz	113	12	,	,	,
cord-003921-8r8z0otz	113	13	recent	recent	JJ
cord-003921-8r8z0otz	113	14	studies	study	NNS
cord-003921-8r8z0otz	113	15	have	have	VBP
cord-003921-8r8z0otz	113	16	identified	identify	VBN
cord-003921-8r8z0otz	113	17	previously	previously	RB
cord-003921-8r8z0otz	113	18	unappreciated	unappreciated	JJ
cord-003921-8r8z0otz	113	19	novel	novel	JJ
cord-003921-8r8z0otz	113	20	role	role	NN
cord-003921-8r8z0otz	113	21	of	of	IN
cord-003921-8r8z0otz	113	22	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	113	23	to	to	TO
cord-003921-8r8z0otz	113	24	control	control	VB
cord-003921-8r8z0otz	113	25	inflammation	inflammation	NN
cord-003921-8r8z0otz	113	26	and	and	CC
cord-003921-8r8z0otz	113	27	resolve	resolve	VB
cord-003921-8r8z0otz	113	28	tissue	tissue	NN
cord-003921-8r8z0otz	113	29	damage	damage	NN
cord-003921-8r8z0otz	113	30	.	.	.
cord-003921-8r8z0otz	114	1	First	first	RB
cord-003921-8r8z0otz	114	2	,	,	,
cord-003921-8r8z0otz	114	3	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	114	4	retain	retain	VBP
cord-003921-8r8z0otz	114	5	the	the	DT
cord-003921-8r8z0otz	114	6	potential	potential	NN
cord-003921-8r8z0otz	114	7	to	to	TO
cord-003921-8r8z0otz	114	8	inhibit	inhibit	VB
cord-003921-8r8z0otz	114	9	T	t	NN
cord-003921-8r8z0otz	114	10	cell	cell	NN
cord-003921-8r8z0otz	114	11	cytotoxicity	cytotoxicity	NN
cord-003921-8r8z0otz	114	12	.	.	.
cord-003921-8r8z0otz	114	13	Arginase-1	arginase-1	NN
cord-003921-8r8z0otz	115	1	(	(	-LRB-
cord-003921-8r8z0otz	115	2	Arg1	Arg1	NNP
cord-003921-8r8z0otz	115	3	,	,	,
cord-003921-8r8z0otz	115	4	a	a	DT
cord-003921-8r8z0otz	115	5	tertiary	tertiary	JJ
cord-003921-8r8z0otz	115	6	granule	granule	NN
cord-003921-8r8z0otz	115	7	content	content	NN
cord-003921-8r8z0otz	115	8	)	)	-RRB-
cord-003921-8r8z0otz	115	9	is	be	VBZ
cord-003921-8r8z0otz	115	10	a	a	DT
cord-003921-8r8z0otz	115	11	manganese	manganese	NN
cord-003921-8r8z0otz	115	12	-	-	HYPH
cord-003921-8r8z0otz	115	13	containing	contain	VBG
cord-003921-8r8z0otz	115	14	enzyme	enzyme	NN
cord-003921-8r8z0otz	115	15	expressed	express	VBN
cord-003921-8r8z0otz	115	16	in	in	IN
cord-003921-8r8z0otz	115	17	mouse	mouse	NN
cord-003921-8r8z0otz	115	18	myeloid	myeloid	NN
cord-003921-8r8z0otz	115	19	cells	cell	NNS
cord-003921-8r8z0otz	115	20	,	,	,
cord-003921-8r8z0otz	115	21	such	such	JJ
cord-003921-8r8z0otz	115	22	as	as	IN
cord-003921-8r8z0otz	115	23	macrophages	macrophage	NNS
cord-003921-8r8z0otz	115	24	.	.	.
cord-003921-8r8z0otz	116	1	However	however	RB
cord-003921-8r8z0otz	116	2	,	,	,
cord-003921-8r8z0otz	116	3	in	in	IN
cord-003921-8r8z0otz	116	4	humans	human	NNS
cord-003921-8r8z0otz	116	5	,	,	,
cord-003921-8r8z0otz	116	6	it	-PRON-	PRP
cord-003921-8r8z0otz	116	7	has	have	VBZ
cord-003921-8r8z0otz	116	8	been	be	VBN
cord-003921-8r8z0otz	116	9	detected	detect	VBN
cord-003921-8r8z0otz	116	10	selectively	selectively	RB
cord-003921-8r8z0otz	116	11	in	in	IN
cord-003921-8r8z0otz	116	12	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	116	13	[	[	-LRB-
cord-003921-8r8z0otz	116	14	58	58	CD
cord-003921-8r8z0otz	116	15	,	,	,
cord-003921-8r8z0otz	116	16	59	59	CD
cord-003921-8r8z0otz	116	17	]	]	-RRB-
cord-003921-8r8z0otz	116	18	,	,	,
cord-003921-8r8z0otz	116	19	whereas	whereas	IN
cord-003921-8r8z0otz	116	20	activated	activate	VBN
cord-003921-8r8z0otz	116	21	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	116	22	release	release	VBP
cord-003921-8r8z0otz	116	23	Arg1	Arg1	NNP
cord-003921-8r8z0otz	116	24	during	during	IN
cord-003921-8r8z0otz	116	25	degranulation	degranulation	NN
cord-003921-8r8z0otz	116	26	process	process	NN
cord-003921-8r8z0otz	116	27	,	,	,
cord-003921-8r8z0otz	116	28	which	which	WDT
cord-003921-8r8z0otz	116	29	inhibit	inhibit	VBP
cord-003921-8r8z0otz	116	30	T	t	NN
cord-003921-8r8z0otz	116	31	cell	cell	NN
cord-003921-8r8z0otz	116	32	proliferation	proliferation	NN
cord-003921-8r8z0otz	116	33	and	and	CC
cord-003921-8r8z0otz	116	34	expansion	expansion	NN
cord-003921-8r8z0otz	116	35	[	[	-LRB-
cord-003921-8r8z0otz	116	36	60	60	CD
cord-003921-8r8z0otz	116	37	,	,	,
cord-003921-8r8z0otz	116	38	61	61	CD
cord-003921-8r8z0otz	116	39	]	]	-RRB-
cord-003921-8r8z0otz	116	40	.	.	.
cord-003921-8r8z0otz	117	1	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	117	2	elastase	elastase	NN
cord-003921-8r8z0otz	117	3	(	(	-LRB-
cord-003921-8r8z0otz	117	4	an	an	DT
cord-003921-8r8z0otz	117	5	azurophilic	azurophilic	JJ
cord-003921-8r8z0otz	117	6	granule	granule	NN
cord-003921-8r8z0otz	117	7	content	content	NN
cord-003921-8r8z0otz	117	8	)	)	-RRB-
cord-003921-8r8z0otz	117	9	cleaves	cleave	VBZ
cord-003921-8r8z0otz	117	10	CD2	CD2	NNP
cord-003921-8r8z0otz	117	11	,	,	,
cord-003921-8r8z0otz	117	12	CD4	CD4	NNP
cord-003921-8r8z0otz	117	13	,	,	,
cord-003921-8r8z0otz	117	14	and	and	CC
cord-003921-8r8z0otz	117	15	CD8	CD8	NNP
cord-003921-8r8z0otz	117	16	on	on	IN
cord-003921-8r8z0otz	117	17	peripheral	peripheral	JJ
cord-003921-8r8z0otz	117	18	blood	blood	NN
cord-003921-8r8z0otz	117	19	T	t	NN
cord-003921-8r8z0otz	117	20	lymphocytes	lymphocyte	NNS
cord-003921-8r8z0otz	117	21	,	,	,
cord-003921-8r8z0otz	117	22	leading	lead	VBG
cord-003921-8r8z0otz	117	23	to	to	IN
cord-003921-8r8z0otz	117	24	reduced	reduce	VBN
cord-003921-8r8z0otz	117	25	IL2	IL2	NNP
cord-003921-8r8z0otz	117	26	production	production	NN
cord-003921-8r8z0otz	117	27	and	and	CC
cord-003921-8r8z0otz	117	28	suppressed	suppress	VBD
cord-003921-8r8z0otz	117	29	T	t	NN
cord-003921-8r8z0otz	117	30	cell	cell	NN
cord-003921-8r8z0otz	117	31	cytotoxicity	cytotoxicity	NN
cord-003921-8r8z0otz	117	32	[	[	-LRB-
cord-003921-8r8z0otz	117	33	62	62	CD
cord-003921-8r8z0otz	117	34	]	]	-RRB-
cord-003921-8r8z0otz	117	35	.	.	.
cord-003921-8r8z0otz	118	1	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	118	2	-	-	HYPH
cord-003921-8r8z0otz	118	3	derived	derive	VBN
cord-003921-8r8z0otz	118	4	ROS	ROS	NNP
cord-003921-8r8z0otz	118	5	may	may	MD
cord-003921-8r8z0otz	118	6	also	also	RB
cord-003921-8r8z0otz	118	7	suppress	suppress	VB
cord-003921-8r8z0otz	118	8	T	t	NN
cord-003921-8r8z0otz	118	9	cells	cell	NNS
cord-003921-8r8z0otz	118	10	via	via	IN
cord-003921-8r8z0otz	118	11	inactivation	inactivation	NN
cord-003921-8r8z0otz	118	12	of	of	IN
cord-003921-8r8z0otz	118	13	coffilin	coffilin	NNP
cord-003921-8r8z0otz	118	14	,	,	,
cord-003921-8r8z0otz	118	15	an	an	DT
cord-003921-8r8z0otz	118	16	actin	actin	NN
cord-003921-8r8z0otz	118	17	-	-	HYPH
cord-003921-8r8z0otz	118	18	remodeling	remodel	VBG
cord-003921-8r8z0otz	118	19	protein	protein	NN
cord-003921-8r8z0otz	118	20	,	,	,
cord-003921-8r8z0otz	118	21	which	which	WDT
cord-003921-8r8z0otz	118	22	impairs	impair	VBZ
cord-003921-8r8z0otz	118	23	formation	formation	NN
cord-003921-8r8z0otz	118	24	of	of	IN
cord-003921-8r8z0otz	118	25	the	the	DT
cord-003921-8r8z0otz	118	26	immune	immune	JJ
cord-003921-8r8z0otz	118	27	synapse	synapse	NN
cord-003921-8r8z0otz	118	28	and	and	CC
cord-003921-8r8z0otz	118	29	cell	cell	NN
cord-003921-8r8z0otz	118	30	activation	activation	NN
cord-003921-8r8z0otz	118	31	[	[	-LRB-
cord-003921-8r8z0otz	118	32	63	63	CD
cord-003921-8r8z0otz	118	33	]	]	-RRB-
cord-003921-8r8z0otz	118	34	.	.	.
cord-003921-8r8z0otz	119	1	Moreover	moreover	RB
cord-003921-8r8z0otz	119	2	,	,	,
cord-003921-8r8z0otz	119	3	as	as	IN
cord-003921-8r8z0otz	119	4	regulatory	regulatory	JJ
cord-003921-8r8z0otz	119	5	T	t	NN
cord-003921-8r8z0otz	119	6	cells	cell	NNS
cord-003921-8r8z0otz	119	7	(	(	-LRB-
cord-003921-8r8z0otz	119	8	Treg	Treg	NNP
cord-003921-8r8z0otz	119	9	)	)	-RRB-
cord-003921-8r8z0otz	119	10	are	be	VBP
cord-003921-8r8z0otz	119	11	less	less	RBR
cord-003921-8r8z0otz	119	12	sensitive	sensitive	JJ
cord-003921-8r8z0otz	119	13	to	to	IN
cord-003921-8r8z0otz	119	14	inhibition	inhibition	NN
cord-003921-8r8z0otz	119	15	by	by	IN
cord-003921-8r8z0otz	119	16	ROS	ROS	NNP
cord-003921-8r8z0otz	119	17	[	[	-LRB-
cord-003921-8r8z0otz	119	18	64	64	CD
cord-003921-8r8z0otz	119	19	]	]	-RRB-
cord-003921-8r8z0otz	119	20	,	,	,
cord-003921-8r8z0otz	119	21	production	production	NN
cord-003921-8r8z0otz	119	22	of	of	IN
cord-003921-8r8z0otz	119	23	ROS	ROS	NNP
cord-003921-8r8z0otz	119	24	by	by	IN
cord-003921-8r8z0otz	119	25	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	119	26	effectively	effectively	RB
cord-003921-8r8z0otz	119	27	creates	create	VBZ
cord-003921-8r8z0otz	119	28	a	a	DT
cord-003921-8r8z0otz	119	29	Treg	Treg	NNP
cord-003921-8r8z0otz	119	30	dominant	dominant	JJ
cord-003921-8r8z0otz	119	31	environment	environment	NN
cord-003921-8r8z0otz	119	32	[	[	-LRB-
cord-003921-8r8z0otz	119	33	65	65	CD
cord-003921-8r8z0otz	119	34	]	]	-RRB-
cord-003921-8r8z0otz	119	35	.	.	.
cord-003921-8r8z0otz	120	1	Several	several	JJ
cord-003921-8r8z0otz	120	2	lines	line	NNS
cord-003921-8r8z0otz	120	3	of	of	IN
cord-003921-8r8z0otz	120	4	evidence	evidence	NN
cord-003921-8r8z0otz	120	5	indicate	indicate	VBP
cord-003921-8r8z0otz	120	6	that	that	IN
cord-003921-8r8z0otz	120	7	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	120	8	can	can	MD
cord-003921-8r8z0otz	120	9	limit	limit	VB
cord-003921-8r8z0otz	120	10	inflammation	inflammation	NN
cord-003921-8r8z0otz	120	11	response	response	NN
cord-003921-8r8z0otz	120	12	in	in	IN
cord-003921-8r8z0otz	120	13	other	other	JJ
cord-003921-8r8z0otz	120	14	innate	innate	JJ
cord-003921-8r8z0otz	120	15	immune	immune	JJ
cord-003921-8r8z0otz	120	16	cells	cell	NNS
cord-003921-8r8z0otz	120	17	.	.	.
cord-003921-8r8z0otz	121	1	Selective	selective	JJ
cord-003921-8r8z0otz	121	2	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	121	3	ablation	ablation	NN
cord-003921-8r8z0otz	121	4	or	or	CC
cord-003921-8r8z0otz	121	5	genetic	genetic	JJ
cord-003921-8r8z0otz	121	6	MPO	MPO	NNP
cord-003921-8r8z0otz	121	7	deletion	deletion	NN
cord-003921-8r8z0otz	121	8	in	in	IN
cord-003921-8r8z0otz	121	9	endotoxinchallenged	endotoxinchallenged	JJ
cord-003921-8r8z0otz	121	10	mice	mouse	NNS
cord-003921-8r8z0otz	121	11	unexpectedly	unexpectedly	RB
cord-003921-8r8z0otz	121	12	enhanced	enhance	VBD
cord-003921-8r8z0otz	121	13	inflammation	inflammation	NN
cord-003921-8r8z0otz	121	14	responses	response	NNS
cord-003921-8r8z0otz	121	15	and	and	CC
cord-003921-8r8z0otz	121	16	increased	increase	VBN
cord-003921-8r8z0otz	121	17	mortality	mortality	NN
cord-003921-8r8z0otz	121	18	,	,	,
cord-003921-8r8z0otz	121	19	indicating	indicate	VBG
cord-003921-8r8z0otz	121	20	that	that	IN
cord-003921-8r8z0otz	121	21	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	121	22	and	and	CC
cord-003921-8r8z0otz	121	23	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	121	24	-	-	HYPH
cord-003921-8r8z0otz	121	25	derived	derive	VBN
cord-003921-8r8z0otz	121	26	MPO	MPO	NNP
cord-003921-8r8z0otz	121	27	can	can	MD
cord-003921-8r8z0otz	121	28	contribute	contribute	VB
cord-003921-8r8z0otz	121	29	to	to	TO
cord-003921-8r8z0otz	121	30	host	host	NN
cord-003921-8r8z0otz	121	31	resistance	resistance	NN
cord-003921-8r8z0otz	121	32	by	by	IN
cord-003921-8r8z0otz	121	33	limiting	limit	VBG
cord-003921-8r8z0otz	121	34	endotoxin	endotoxin	NN
cord-003921-8r8z0otz	121	35	-	-	HYPH
cord-003921-8r8z0otz	121	36	driven	drive	VBN
cord-003921-8r8z0otz	121	37	innate	innate	JJ
cord-003921-8r8z0otz	121	38	immune	immune	JJ
cord-003921-8r8z0otz	121	39	pathology	pathology	NN
cord-003921-8r8z0otz	121	40	[	[	-LRB-
cord-003921-8r8z0otz	121	41	50•	50•	CD
cord-003921-8r8z0otz	121	42	]	]	-RRB-
cord-003921-8r8z0otz	121	43	.	.	.
cord-003921-8r8z0otz	122	1	Cathepsin	Cathepsin	NNP
cord-003921-8r8z0otz	122	2	G	G	NNP
cord-003921-8r8z0otz	122	3	(	(	-LRB-
cord-003921-8r8z0otz	122	4	an	an	DT
cord-003921-8r8z0otz	122	5	azurophilic	azurophilic	JJ
cord-003921-8r8z0otz	122	6	granule	granule	NN
cord-003921-8r8z0otz	122	7	content	content	NN
cord-003921-8r8z0otz	122	8	)	)	-RRB-
cord-003921-8r8z0otz	122	9	cleaves	cleave	VBZ
cord-003921-8r8z0otz	122	10	NKp46	NKp46	NNP
cord-003921-8r8z0otz	122	11	and	and	CC
cord-003921-8r8z0otz	122	12	impairs	impair	VBZ
cord-003921-8r8z0otz	122	13	NKp46-mediated	nkp46-mediated	JJ
cord-003921-8r8z0otz	122	14	responses	response	NNS
cord-003921-8r8z0otz	122	15	of	of	IN
cord-003921-8r8z0otz	122	16	NK	NK	NNP
cord-003921-8r8z0otz	122	17	cells	cell	NNS
cord-003921-8r8z0otz	122	18	,	,	,
cord-003921-8r8z0otz	122	19	including	include	VBG
cord-003921-8r8z0otz	122	20	IFNγ	IFNγ	NNS
cord-003921-8r8z0otz	122	21	production	production	NN
cord-003921-8r8z0otz	122	22	and	and	CC
cord-003921-8r8z0otz	122	23	cell	cell	NN
cord-003921-8r8z0otz	122	24	degranulation	degranulation	NN
cord-003921-8r8z0otz	122	25	[	[	-LRB-
cord-003921-8r8z0otz	122	26	66	66	CD
cord-003921-8r8z0otz	122	27	]	]	-RRB-
cord-003921-8r8z0otz	122	28	.	.	.
cord-003921-8r8z0otz	123	1	Neutrophilderived	Neutrophilderived	NNP
cord-003921-8r8z0otz	123	2	microvesicles	microvesicle	NNS
cord-003921-8r8z0otz	123	3	cause	cause	VBP
cord-003921-8r8z0otz	123	4	macrophages	macrophage	NNS
cord-003921-8r8z0otz	123	5	to	to	TO
cord-003921-8r8z0otz	123	6	generate	generate	VB
cord-003921-8r8z0otz	123	7	lipid	lipid	NN
cord-003921-8r8z0otz	123	8	pro	pro	JJ
cord-003921-8r8z0otz	123	9	-	-	JJ
cord-003921-8r8z0otz	123	10	resolving	resolve	VBG
cord-003921-8r8z0otz	123	11	mediators	mediator	NNS
cord-003921-8r8z0otz	123	12	and	and	CC
cord-003921-8r8z0otz	123	13	TGFβ	TGFβ	NNS
cord-003921-8r8z0otz	123	14	,	,	,
cord-003921-8r8z0otz	123	15	leading	lead	VBG
cord-003921-8r8z0otz	123	16	to	to	TO
cord-003921-8r8z0otz	123	17	counter	counter	VB
cord-003921-8r8z0otz	123	18	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	123	19	response	response	NN
cord-003921-8r8z0otz	123	20	[	[	-LRB-
cord-003921-8r8z0otz	123	21	67	67	CD
cord-003921-8r8z0otz	123	22	]	]	-RRB-
cord-003921-8r8z0otz	123	23	.	.	.
cord-003921-8r8z0otz	124	1	Dead	dead	JJ
cord-003921-8r8z0otz	124	2	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	124	3	secret	secret	JJ
cord-003921-8r8z0otz	124	4	cytosolic	cytosolic	JJ
cord-003921-8r8z0otz	124	5	protein	protein	NN
cord-003921-8r8z0otz	124	6	annexin	annexin	NNP
cord-003921-8r8z0otz	124	7	A1	A1	NNP
cord-003921-8r8z0otz	124	8	(	(	-LRB-
cord-003921-8r8z0otz	124	9	AnxA1	AnxA1	NNP
cord-003921-8r8z0otz	124	10	)	)	-RRB-
cord-003921-8r8z0otz	124	11	,	,	,
cord-003921-8r8z0otz	124	12	which	which	WDT
cord-003921-8r8z0otz	124	13	limits	limit	VBZ
cord-003921-8r8z0otz	124	14	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	124	15	migration	migration	NN
cord-003921-8r8z0otz	124	16	by	by	IN
cord-003921-8r8z0otz	124	17	interacting	interact	VBG
cord-003921-8r8z0otz	124	18	with	with	IN
cord-003921-8r8z0otz	124	19	formyl	formyl	NNP
cord-003921-8r8z0otz	124	20	peptide	peptide	NN
cord-003921-8r8z0otz	124	21	receptor	receptor	NN
cord-003921-8r8z0otz	124	22	2	2	CD
cord-003921-8r8z0otz	124	23	(	(	-LRB-
cord-003921-8r8z0otz	124	24	FPR2	FPR2	NNP
cord-003921-8r8z0otz	124	25	)	)	-RRB-
cord-003921-8r8z0otz	125	1	[	[	-LRB-
cord-003921-8r8z0otz	125	2	68	68	CD
cord-003921-8r8z0otz	125	3	,	,	,
cord-003921-8r8z0otz	125	4	69	69	CD
cord-003921-8r8z0otz	125	5	]	]	-RRB-
cord-003921-8r8z0otz	125	6	and	and	CC
cord-003921-8r8z0otz	125	7	prompts	prompt	VBZ
cord-003921-8r8z0otz	125	8	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	125	9	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	125	10	[	[	-LRB-
cord-003921-8r8z0otz	125	11	70	70	CD
cord-003921-8r8z0otz	125	12	]	]	-RRB-
cord-003921-8r8z0otz	125	13	.	.	.
cord-003921-8r8z0otz	126	1	Clearance	clearance	NN
cord-003921-8r8z0otz	126	2	of	of	IN
cord-003921-8r8z0otz	126	3	apoptotic	apoptotic	JJ
cord-003921-8r8z0otz	126	4	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	126	5	by	by	IN
cord-003921-8r8z0otz	126	6	macrophage	macrophage	NN
cord-003921-8r8z0otz	126	7	efferocytosis	efferocytosis	NN
cord-003921-8r8z0otz	126	8	may	may	MD
cord-003921-8r8z0otz	126	9	then	then	RB
cord-003921-8r8z0otz	126	10	switch	switch	VB
cord-003921-8r8z0otz	126	11	macrophages	macrophage	NNS
cord-003921-8r8z0otz	126	12	to	to	IN
cord-003921-8r8z0otz	126	13	anti	anti	JJ
cord-003921-8r8z0otz	126	14	-	-	JJ
cord-003921-8r8z0otz	126	15	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	126	16	IL10	IL10	NNP
cord-003921-8r8z0otz	126	17	/	/	SYM
cord-003921-8r8z0otz	126	18	TGFβ	TGFβ	NNP
cord-003921-8r8z0otz	126	19	dominant	dominant	JJ
cord-003921-8r8z0otz	126	20	phenotype	phenotype	NN
cord-003921-8r8z0otz	126	21	,	,	,
cord-003921-8r8z0otz	126	22	leading	lead	VBG
cord-003921-8r8z0otz	126	23	to	to	IN
cord-003921-8r8z0otz	126	24	tissue	tissue	NN
cord-003921-8r8z0otz	126	25	-	-	HYPH
cord-003921-8r8z0otz	126	26	repairing	repair	VBG
cord-003921-8r8z0otz	126	27	environment	environment	NN
cord-003921-8r8z0otz	126	28	as	as	RB
cord-003921-8r8z0otz	126	29	well	well	RB
cord-003921-8r8z0otz	126	30	as	as	IN
cord-003921-8r8z0otz	126	31	Treg	Treg	NNP
cord-003921-8r8z0otz	126	32	dominated	dominate	VBD
cord-003921-8r8z0otz	126	33	immune	immune	JJ
cord-003921-8r8z0otz	126	34	tolerance	tolerance	NN
cord-003921-8r8z0otz	126	35	.	.	.
cord-003921-8r8z0otz	127	1	Analogous	analogous	JJ
cord-003921-8r8z0otz	127	2	to	to	IN
cord-003921-8r8z0otz	127	3	the	the	DT
cord-003921-8r8z0otz	127	4	concept	concept	NN
cord-003921-8r8z0otz	127	5	of	of	IN
cord-003921-8r8z0otz	127	6	pro	pro	JJ
cord-003921-8r8z0otz	127	7	-	-	JJ
cord-003921-8r8z0otz	127	8	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	127	9	(	(	-LRB-
cord-003921-8r8z0otz	127	10	M1	M1	NNP
cord-003921-8r8z0otz	127	11	)	)	-RRB-
cord-003921-8r8z0otz	127	12	and	and	CC
cord-003921-8r8z0otz	127	13	anti	anti	JJ
cord-003921-8r8z0otz	127	14	-	-	JJ
cord-003921-8r8z0otz	127	15	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	127	16	(	(	-LRB-
cord-003921-8r8z0otz	127	17	M2	M2	NNP
cord-003921-8r8z0otz	127	18	)	)	-RRB-
cord-003921-8r8z0otz	127	19	macrophage	macrophage	NN
cord-003921-8r8z0otz	127	20	phenotypes	phenotype	NNS
cord-003921-8r8z0otz	127	21	[	[	-LRB-
cord-003921-8r8z0otz	127	22	71	71	CD
cord-003921-8r8z0otz	127	23	]	]	-RRB-
cord-003921-8r8z0otz	127	24	,	,	,
cord-003921-8r8z0otz	127	25	tissuespecific	tissuespecific	JJ
cord-003921-8r8z0otz	127	26	microenvironment	microenvironment	NN
cord-003921-8r8z0otz	127	27	may	may	MD
cord-003921-8r8z0otz	127	28	promote	promote	VB
cord-003921-8r8z0otz	127	29	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	127	30	polarization	polarization	NN
cord-003921-8r8z0otz	127	31	into	into	IN
cord-003921-8r8z0otz	127	32	two	two	CD
cord-003921-8r8z0otz	127	33	distinct	distinct	JJ
cord-003921-8r8z0otz	127	34	phenotypes	phenotype	NNS
cord-003921-8r8z0otz	127	35	[	[	-LRB-
cord-003921-8r8z0otz	127	36	72	72	CD
cord-003921-8r8z0otz	127	37	]	]	-RRB-
cord-003921-8r8z0otz	127	38	.	.	.
cord-003921-8r8z0otz	128	1	Thus	thus	RB
cord-003921-8r8z0otz	128	2	,	,	,
cord-003921-8r8z0otz	128	3	N1	n1	NN
cord-003921-8r8z0otz	128	4	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	128	5	are	be	VBP
cord-003921-8r8z0otz	128	6	anti	anti	JJ
cord-003921-8r8z0otz	128	7	-	-	JJ
cord-003921-8r8z0otz	128	8	tumoral	tumoral	JJ
cord-003921-8r8z0otz	128	9	/	/	SYM
cord-003921-8r8z0otz	128	10	pro	pro	JJ
cord-003921-8r8z0otz	128	11	-	-	JJ
cord-003921-8r8z0otz	128	12	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	128	13	,	,	,
cord-003921-8r8z0otz	128	14	having	have	VBG
cord-003921-8r8z0otz	128	15	increased	increase	VBN
cord-003921-8r8z0otz	128	16	TNFα	TNFα	NNP
cord-003921-8r8z0otz	128	17	expression	expression	NN
cord-003921-8r8z0otz	128	18	and	and	CC
cord-003921-8r8z0otz	128	19	reduced	reduce	VBN
cord-003921-8r8z0otz	128	20	arginase	arginase	NN
cord-003921-8r8z0otz	128	21	/	/	SYM
cord-003921-8r8z0otz	128	22	CXCR4	CXCR4	NNP
cord-003921-8r8z0otz	128	23	/	/	SYM
cord-003921-8r8z0otz	128	24	MMP-9	MMP-9	NNP
cord-003921-8r8z0otz	128	25	/	/	SYM
cord-003921-8r8z0otz	128	26	VEGF	VEGF	NNP
cord-003921-8r8z0otz	128	27	levels	level	NNS
cord-003921-8r8z0otz	128	28	,	,	,
cord-003921-8r8z0otz	128	29	whereas	whereas	IN
cord-003921-8r8z0otz	128	30	N2	n2	NN
cord-003921-8r8z0otz	128	31	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	128	32	are	be	VBP
cord-003921-8r8z0otz	128	33	pro	pro	JJ
cord-003921-8r8z0otz	128	34	-	-	JJ
cord-003921-8r8z0otz	128	35	tumoral	tumoral	JJ
cord-003921-8r8z0otz	128	36	/	/	SYM
cord-003921-8r8z0otz	128	37	anti	anti	JJ
cord-003921-8r8z0otz	128	38	-	-	JJ
cord-003921-8r8z0otz	128	39	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	128	40	and	and	CC
cord-003921-8r8z0otz	128	41	characterized	characterize	VBN
cord-003921-8r8z0otz	128	42	by	by	IN
cord-003921-8r8z0otz	128	43	decreased	decrease	VBN
cord-003921-8r8z0otz	128	44	TNFα	TNFα	NNS
cord-003921-8r8z0otz	128	45	and	and	CC
cord-003921-8r8z0otz	128	46	increased	increase	VBN
cord-003921-8r8z0otz	128	47	arginase	arginase	NN
cord-003921-8r8z0otz	128	48	/	/	SYM
cord-003921-8r8z0otz	128	49	CXCR4	CXCR4	NNP
cord-003921-8r8z0otz	128	50	/	/	SYM
cord-003921-8r8z0otz	128	51	MMP-9	MMP-9	NNP
cord-003921-8r8z0otz	128	52	/	/	SYM
cord-003921-8r8z0otz	128	53	VEGF	VEGF	NNP
cord-003921-8r8z0otz	128	54	expression	expression	NN
cord-003921-8r8z0otz	128	55	[	[	-LRB-
cord-003921-8r8z0otz	128	56	73	73	CD
cord-003921-8r8z0otz	128	57	,	,	,
cord-003921-8r8z0otz	128	58	74	74	CD
cord-003921-8r8z0otz	128	59	]	]	-RRB-
cord-003921-8r8z0otz	128	60	.	.	.
cord-003921-8r8z0otz	129	1	Several	several	JJ
cord-003921-8r8z0otz	129	2	cytokines	cytokine	NNS
cord-003921-8r8z0otz	129	3	may	may	MD
cord-003921-8r8z0otz	129	4	contribute	contribute	VB
cord-003921-8r8z0otz	129	5	to	to	IN
cord-003921-8r8z0otz	129	6	N1	N1	NNP
cord-003921-8r8z0otz	129	7	/	/	SYM
cord-003921-8r8z0otz	129	8	N2	N2	NNP
cord-003921-8r8z0otz	129	9	polarization	polarization	NN
cord-003921-8r8z0otz	129	10	,	,	,
cord-003921-8r8z0otz	129	11	with	with	IN
cord-003921-8r8z0otz	129	12	TGFβ	TGFβ	NNS
cord-003921-8r8z0otz	129	13	promoting	promote	VBG
cord-003921-8r8z0otz	129	14	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	129	15	to	to	TO
cord-003921-8r8z0otz	129	16	acquire	acquire	VB
cord-003921-8r8z0otz	129	17	N2	n2	NN
cord-003921-8r8z0otz	129	18	phenotype	phenotype	NN
cord-003921-8r8z0otz	129	19	by	by	IN
cord-003921-8r8z0otz	129	20	simultaneously	simultaneously	RB
cord-003921-8r8z0otz	129	21	inhibiting	inhibit	VBG
cord-003921-8r8z0otz	129	22	N1	n1	NN
cord-003921-8r8z0otz	129	23	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	129	24	generation	generation	NN
cord-003921-8r8z0otz	129	25	[	[	-LRB-
cord-003921-8r8z0otz	129	26	72	72	CD
cord-003921-8r8z0otz	129	27	]	]	-RRB-
cord-003921-8r8z0otz	129	28	.	.	.
cord-003921-8r8z0otz	130	1	Endogenous	endogenous	JJ
cord-003921-8r8z0otz	130	2	IFNβ	IFNβ	NNS
cord-003921-8r8z0otz	130	3	imprints	imprint	NNS
cord-003921-8r8z0otz	130	4	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	130	5	to	to	IN
cord-003921-8r8z0otz	130	6	N1	n1	NN
cord-003921-8r8z0otz	130	7	phenotype	phenotype	NN
cord-003921-8r8z0otz	130	8	,	,	,
cord-003921-8r8z0otz	130	9	which	which	WDT
cord-003921-8r8z0otz	130	10	restrict	restrict	VBP
cord-003921-8r8z0otz	130	11	tumor	tumor	NN
cord-003921-8r8z0otz	130	12	angiogenesis	angiogenesis	NN
cord-003921-8r8z0otz	130	13	and	and	CC
cord-003921-8r8z0otz	130	14	enhance	enhance	VB
cord-003921-8r8z0otz	130	15	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	130	16	cytotoxicity	cytotoxicity	NN
cord-003921-8r8z0otz	130	17	[	[	-LRB-
cord-003921-8r8z0otz	130	18	75	75	CD
cord-003921-8r8z0otz	130	19	]	]	-RRB-
cord-003921-8r8z0otz	130	20	.	.	.
cord-003921-8r8z0otz	131	1	A	a	DT
cord-003921-8r8z0otz	131	2	recent	recent	JJ
cord-003921-8r8z0otz	131	3	study	study	NN
cord-003921-8r8z0otz	131	4	demonstrated	demonstrate	VBD
cord-003921-8r8z0otz	131	5	that	that	IN
cord-003921-8r8z0otz	131	6	analogous	analogous	JJ
cord-003921-8r8z0otz	131	7	to	to	IN
cord-003921-8r8z0otz	131	8	M1	M1	NNP
cord-003921-8r8z0otz	131	9	/	/	SYM
cord-003921-8r8z0otz	131	10	M2	m2	JJ
cord-003921-8r8z0otz	131	11	macrophage	macrophage	NN
cord-003921-8r8z0otz	131	12	polarization	polarization	NN
cord-003921-8r8z0otz	131	13	,	,	,
cord-003921-8r8z0otz	131	14	LPS	LPS	NNP
cord-003921-8r8z0otz	131	15	and	and	CC
cord-003921-8r8z0otz	131	16	IFNγ	IFNγ	NNS
cord-003921-8r8z0otz	131	17	drove	drive	VBD
cord-003921-8r8z0otz	131	18	peripheral	peripheral	JJ
cord-003921-8r8z0otz	131	19	blood	blood	NN
cord-003921-8r8z0otz	131	20	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	131	21	toward	toward	IN
cord-003921-8r8z0otz	131	22	N1	N1	NNP
cord-003921-8r8z0otz	131	23	phenotype	phenotype	NN
cord-003921-8r8z0otz	131	24	while	while	IN
cord-003921-8r8z0otz	131	25	IL4	IL4	NNP
cord-003921-8r8z0otz	131	26	polarized	polarize	VBD
cord-003921-8r8z0otz	131	27	toward	toward	IN
cord-003921-8r8z0otz	131	28	N2	N2	NNP
cord-003921-8r8z0otz	131	29	phenotype	phenotype	NN
cord-003921-8r8z0otz	131	30	[	[	-LRB-
cord-003921-8r8z0otz	131	31	76	76	CD
cord-003921-8r8z0otz	131	32	]	]	-RRB-
cord-003921-8r8z0otz	131	33	.	.	.
cord-003921-8r8z0otz	132	1	In	in	IN
cord-003921-8r8z0otz	132	2	addition	addition	NN
cord-003921-8r8z0otz	132	3	,	,	,
cord-003921-8r8z0otz	132	4	murine	murine	JJ
cord-003921-8r8z0otz	132	5	infarctedmyocardium	infarctedmyocardium	NN
cord-003921-8r8z0otz	132	6	was	be	VBD
cord-003921-8r8z0otz	132	7	infiltrated	infiltrate	VBN
cord-003921-8r8z0otz	132	8	by	by	IN
cord-003921-8r8z0otz	132	9	day	day	NN
cord-003921-8r8z0otz	132	10	1	1	CD
cord-003921-8r8z0otz	132	11	with	with	IN
cord-003921-8r8z0otz	132	12	N1	N1	NNP
cord-003921-8r8z0otz	132	13	dominant	dominant	JJ
cord-003921-8r8z0otz	132	14	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	132	15	expressing	express	VBG
cord-003921-8r8z0otz	132	16	pro	pro	JJ
cord-003921-8r8z0otz	132	17	-	-	JJ
cord-003921-8r8z0otz	132	18	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	132	19	markers	marker	NNS
cord-003921-8r8z0otz	132	20	,	,	,
cord-003921-8r8z0otz	132	21	whereas	whereas	IN
cord-003921-8r8z0otz	132	22	N2	n2	NN
cord-003921-8r8z0otz	132	23	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	132	24	increased	increase	VBN
cord-003921-8r8z0otz	132	25	by	by	IN
cord-003921-8r8z0otz	132	26	day	day	NN
cord-003921-8r8z0otz	132	27	7	7	CD
cord-003921-8r8z0otz	132	28	concomitantly	concomitantly	RB
cord-003921-8r8z0otz	132	29	with	with	IN
cord-003921-8r8z0otz	132	30	enhanced	enhance	VBN
cord-003921-8r8z0otz	132	31	levels	level	NNS
cord-003921-8r8z0otz	132	32	of	of	IN
cord-003921-8r8z0otz	132	33	anti	anti	JJ
cord-003921-8r8z0otz	132	34	-	-	JJ
cord-003921-8r8z0otz	132	35	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	132	36	markers	marker	NNS
cord-003921-8r8z0otz	132	37	,	,	,
cord-003921-8r8z0otz	132	38	supporting	support	VBG
cord-003921-8r8z0otz	132	39	putative	putative	JJ
cord-003921-8r8z0otz	132	40	role	role	NN
cord-003921-8r8z0otz	132	41	of	of	IN
cord-003921-8r8z0otz	132	42	N2	N2	NNP
cord-003921-8r8z0otz	132	43	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	132	44	in	in	IN
cord-003921-8r8z0otz	132	45	the	the	DT
cord-003921-8r8z0otz	132	46	resolution	resolution	NN
cord-003921-8r8z0otz	132	47	of	of	IN
cord-003921-8r8z0otz	132	48	inflammation	inflammation	NN
cord-003921-8r8z0otz	132	49	and	and	CC
cord-003921-8r8z0otz	132	50	promoting	promote	VBG
cord-003921-8r8z0otz	132	51	tissue	tissue	NN
cord-003921-8r8z0otz	132	52	repair	repair	NN
cord-003921-8r8z0otz	132	53	[	[	-LRB-
cord-003921-8r8z0otz	132	54	76	76	CD
cord-003921-8r8z0otz	132	55	]	]	-RRB-
cord-003921-8r8z0otz	132	56	.	.	.
cord-003921-8r8z0otz	133	1	Noteworthy	noteworthy	JJ
cord-003921-8r8z0otz	133	2	,	,	,
cord-003921-8r8z0otz	133	3	rosiglitazone	rosiglitazone	NN
cord-003921-8r8z0otz	133	4	(	(	-LRB-
cord-003921-8r8z0otz	133	5	peroxisome	peroxisome	NN
cord-003921-8r8z0otz	133	6	proliferator	proliferator	NN
cord-003921-8r8z0otz	133	7	-	-	HYPH
cord-003921-8r8z0otz	133	8	activated	activate	VBN
cord-003921-8r8z0otz	133	9	receptor	receptor	NN
cord-003921-8r8z0otz	133	10	-	-	HYPH
cord-003921-8r8z0otz	133	11	γ	γ	NN
cord-003921-8r8z0otz	133	12	agonist	agonist	NN
cord-003921-8r8z0otz	133	13	)	)	-RRB-
cord-003921-8r8z0otz	133	14	treatment	treatment	NN
cord-003921-8r8z0otz	133	15	in	in	IN
cord-003921-8r8z0otz	133	16	a	a	DT
cord-003921-8r8z0otz	133	17	mouse	mouse	NN
cord-003921-8r8z0otz	133	18	brain	brain	NN
cord-003921-8r8z0otz	133	19	stroke	stroke	NN
cord-003921-8r8z0otz	133	20	model	model	NN
cord-003921-8r8z0otz	133	21	shifted	shift	VBD
cord-003921-8r8z0otz	133	22	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	133	23	population	population	NN
cord-003921-8r8z0otz	133	24	toward	toward	IN
cord-003921-8r8z0otz	133	25	N2	N2	NNP
cord-003921-8r8z0otz	133	26	phenotype	phenotype	NN
cord-003921-8r8z0otz	133	27	(	(	-LRB-
cord-003921-8r8z0otz	133	28	31	31	CD
cord-003921-8r8z0otz	133	29	%	%	NN
cord-003921-8r8z0otz	133	30	vs.	vs.	IN
cord-003921-8r8z0otz	133	31	77	77	CD
cord-003921-8r8z0otz	133	32	%	%	NN
cord-003921-8r8z0otz	133	33	)	)	-RRB-
cord-003921-8r8z0otz	133	34	,	,	,
cord-003921-8r8z0otz	133	35	suppressed	suppress	VBN
cord-003921-8r8z0otz	133	36	inflammation	inflammation	NN
cord-003921-8r8z0otz	133	37	,	,	,
cord-003921-8r8z0otz	133	38	enhanced	enhanced	JJ
cord-003921-8r8z0otz	133	39	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	133	40	clearance	clearance	NN
cord-003921-8r8z0otz	133	41	,	,	,
cord-003921-8r8z0otz	133	42	and	and	CC
cord-003921-8r8z0otz	133	43	alleviated	alleviate	VBN
cord-003921-8r8z0otz	133	44	brain	brain	NN
cord-003921-8r8z0otz	133	45	damage	damage	NN
cord-003921-8r8z0otz	133	46	[	[	-LRB-
cord-003921-8r8z0otz	133	47	77	77	CD
cord-003921-8r8z0otz	133	48	]	]	-RRB-
cord-003921-8r8z0otz	133	49	.	.	.
cord-003921-8r8z0otz	134	1	Although	although	IN
cord-003921-8r8z0otz	134	2	macrophage	macrophage	NN
cord-003921-8r8z0otz	134	3	M1	M1	NNP
cord-003921-8r8z0otz	134	4	/	/	SYM
cord-003921-8r8z0otz	134	5	M2	m2	NN
cord-003921-8r8z0otz	134	6	plasticity	plasticity	NN
cord-003921-8r8z0otz	134	7	is	be	VBZ
cord-003921-8r8z0otz	134	8	broadly	broadly	RB
cord-003921-8r8z0otz	134	9	accepted	accept	VBN
cord-003921-8r8z0otz	134	10	[	[	-LRB-
cord-003921-8r8z0otz	134	11	78	78	CD
cord-003921-8r8z0otz	134	12	]	]	-RRB-
cord-003921-8r8z0otz	134	13	,	,	,
cord-003921-8r8z0otz	134	14	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	134	15	generally	generally	RB
cord-003921-8r8z0otz	134	16	have	have	VBP
cord-003921-8r8z0otz	134	17	short	short	JJ
cord-003921-8r8z0otz	134	18	lifespan	lifespan	NN
cord-003921-8r8z0otz	134	19	(	(	-LRB-
cord-003921-8r8z0otz	134	20	6	6	CD
cord-003921-8r8z0otz	134	21	-	-	SYM
cord-003921-8r8z0otz	134	22	8	8	CD
cord-003921-8r8z0otz	134	23	h	h	NN
cord-003921-8r8z0otz	134	24	in	in	IN
cord-003921-8r8z0otz	134	25	blood	blood	NN
cord-003921-8r8z0otz	134	26	stream	stream	NN
cord-003921-8r8z0otz	134	27	)	)	-RRB-
cord-003921-8r8z0otz	134	28	,	,	,
cord-003921-8r8z0otz	134	29	their	-PRON-	PRP$
cord-003921-8r8z0otz	134	30	plasticity	plasticity	NN
cord-003921-8r8z0otz	134	31	remains	remain	VBZ
cord-003921-8r8z0otz	134	32	unknown	unknown	JJ
cord-003921-8r8z0otz	134	33	.	.	.
cord-003921-8r8z0otz	135	1	Future	future	JJ
cord-003921-8r8z0otz	135	2	studies	study	NNS
cord-003921-8r8z0otz	135	3	need	need	VBP
cord-003921-8r8z0otz	135	4	to	to	TO
cord-003921-8r8z0otz	135	5	elucidate	elucidate	VB
cord-003921-8r8z0otz	135	6	whether	whether	IN
cord-003921-8r8z0otz	135	7	N1	N1	NNP
cord-003921-8r8z0otz	135	8	/	/	SYM
cord-003921-8r8z0otz	135	9	N2	N2	NNP
cord-003921-8r8z0otz	135	10	polarization	polarization	NN
cord-003921-8r8z0otz	135	11	is	be	VBZ
cord-003921-8r8z0otz	135	12	dominated	dominate	VBN
cord-003921-8r8z0otz	135	13	by	by	IN
cord-003921-8r8z0otz	135	14	re	re	NN
cord-003921-8r8z0otz	135	15	-	-	NN
cord-003921-8r8z0otz	135	16	programming	programming	NN
cord-003921-8r8z0otz	135	17	of	of	IN
cord-003921-8r8z0otz	135	18	existing	exist	VBG
cord-003921-8r8z0otz	135	19	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	135	20	or	or	CC
cord-003921-8r8z0otz	135	21	environmental	environmental	JJ
cord-003921-8r8z0otz	135	22	influence	influence	NN
cord-003921-8r8z0otz	135	23	on	on	IN
cord-003921-8r8z0otz	135	24	de	de	NNP
cord-003921-8r8z0otz	135	25	novo	novo	NNP
cord-003921-8r8z0otz	135	26	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	135	27	populations	population	NNS
cord-003921-8r8z0otz	135	28	.	.	.
cord-003921-8r8z0otz	136	1	By	by	IN
cord-003921-8r8z0otz	136	2	virtue	virtue	NN
cord-003921-8r8z0otz	136	3	of	of	IN
cord-003921-8r8z0otz	136	4	technological	technological	JJ
cord-003921-8r8z0otz	136	5	advances	advance	NNS
cord-003921-8r8z0otz	136	6	and	and	CC
cord-003921-8r8z0otz	136	7	efforts	effort	NNS
cord-003921-8r8z0otz	136	8	to	to	TO
cord-003921-8r8z0otz	136	9	identify	identify	VB
cord-003921-8r8z0otz	136	10	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	136	11	heterogeneity	heterogeneity	NN
cord-003921-8r8z0otz	136	12	,	,	,
cord-003921-8r8z0otz	136	13	additional	additional	JJ
cord-003921-8r8z0otz	136	14	antiinflammatory	antiinflammatory	JJ
cord-003921-8r8z0otz	136	15	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	136	16	subsets	subset	NNS
cord-003921-8r8z0otz	136	17	have	have	VBP
cord-003921-8r8z0otz	136	18	been	be	VBN
cord-003921-8r8z0otz	136	19	recognized	recognize	VBN
cord-003921-8r8z0otz	136	20	.	.	.
cord-003921-8r8z0otz	137	1	Studies	study	NNS
cord-003921-8r8z0otz	137	2	by	by	IN
cord-003921-8r8z0otz	137	3	Tirouvanziam	Tirouvanziam	NNP
cord-003921-8r8z0otz	137	4	et	et	NNP
cord-003921-8r8z0otz	137	5	al	al	NNP
cord-003921-8r8z0otz	137	6	.	.	NNP
cord-003921-8r8z0otz	137	7	identified	identify	VBD
cord-003921-8r8z0otz	137	8	a	a	DT
cord-003921-8r8z0otz	137	9	CD63+/MHC	cd63+/mhc	JJ
cord-003921-8r8z0otz	137	10	-	-	HYPH
cord-003921-8r8z0otz	137	11	II+/CD80+/CD294	ii+/cd80+/cd294	JJ
cord-003921-8r8z0otz	137	12	+	+	CC
cord-003921-8r8z0otz	137	13	human	human	JJ
cord-003921-8r8z0otz	137	14	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	137	15	subset	subset	VBN
cord-003921-8r8z0otz	137	16	in	in	IN
cord-003921-8r8z0otz	137	17	mature	mature	JJ
cord-003921-8r8z0otz	137	18	cystic	cystic	JJ
cord-003921-8r8z0otz	137	19	fibrosis	fibrosis	NN
cord-003921-8r8z0otz	137	20	airway	airway	NN
cord-003921-8r8z0otz	137	21	,	,	,
cord-003921-8r8z0otz	137	22	which	which	WDT
cord-003921-8r8z0otz	137	23	retained	retain	VBD
cord-003921-8r8z0otz	137	24	anabolic	anabolic	JJ
cord-003921-8r8z0otz	137	25	/	/	SYM
cord-003921-8r8z0otz	137	26	pro	pro	JJ
cord-003921-8r8z0otz	137	27	-	-	JJ
cord-003921-8r8z0otz	137	28	survival	survival	JJ
cord-003921-8r8z0otz	137	29	phenotype	phenotype	NN
cord-003921-8r8z0otz	137	30	and	and	CC
cord-003921-8r8z0otz	137	31	suppressed	suppress	VBD
cord-003921-8r8z0otz	137	32	T	T	NNP
cord-003921-8r8z0otz	137	33	cell	cell	NN
cord-003921-8r8z0otz	137	34	function	function	NN
cord-003921-8r8z0otz	137	35	[	[	-LRB-
cord-003921-8r8z0otz	137	36	60	60	CD
cord-003921-8r8z0otz	137	37	,	,	,
cord-003921-8r8z0otz	137	38	79	79	CD
cord-003921-8r8z0otz	137	39	]	]	-RRB-
cord-003921-8r8z0otz	137	40	.	.	.
cord-003921-8r8z0otz	138	1	Pillay	Pillay	NNP
cord-003921-8r8z0otz	138	2	et	et	NNP
cord-003921-8r8z0otz	138	3	al	al	NNP
cord-003921-8r8z0otz	138	4	.	.	NNP
cord-003921-8r8z0otz	138	5	found	find	VBD
cord-003921-8r8z0otz	138	6	a	a	DT
cord-003921-8r8z0otz	138	7	subset	subset	NN
cord-003921-8r8z0otz	138	8	of	of	IN
cord-003921-8r8z0otz	138	9	mature	mature	JJ
cord-003921-8r8z0otz	138	10	human	human	JJ
cord-003921-8r8z0otz	138	11	CD16	CD16	NNP
cord-003921-8r8z0otz	138	12	bright	bright	JJ
cord-003921-8r8z0otz	138	13	/CD62L	/CD62L	,
cord-003921-8r8z0otz	138	14	dim	dim	JJ
cord-003921-8r8z0otz	138	15	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	138	16	in	in	IN
cord-003921-8r8z0otz	138	17	endotoxin	endotoxin	NN
cord-003921-8r8z0otz	138	18	-	-	HYPH
cord-003921-8r8z0otz	138	19	challenged	challenge	VBN
cord-003921-8r8z0otz	138	20	blood	blood	NN
cord-003921-8r8z0otz	138	21	,	,	,
cord-003921-8r8z0otz	138	22	which	which	WDT
cord-003921-8r8z0otz	138	23	suppressed	suppress	VBD
cord-003921-8r8z0otz	138	24	T	t	NN
cord-003921-8r8z0otz	138	25	cell	cell	NN
cord-003921-8r8z0otz	138	26	proliferation	proliferation	NN
cord-003921-8r8z0otz	138	27	via	via	IN
cord-003921-8r8z0otz	138	28	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	138	29	MAC-1	MAC-1	NNP
cord-003921-8r8z0otz	138	30	dependent	dependent	JJ
cord-003921-8r8z0otz	138	31	manner	manner	NN
cord-003921-8r8z0otz	138	32	[	[	-LRB-
cord-003921-8r8z0otz	138	33	80	80	CD
cord-003921-8r8z0otz	138	34	]	]	-RRB-
cord-003921-8r8z0otz	138	35	.	.	.
cord-003921-8r8z0otz	139	1	Neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	139	2	may	may	MD
cord-003921-8r8z0otz	139	3	also	also	RB
cord-003921-8r8z0otz	139	4	contribute	contribute	VB
cord-003921-8r8z0otz	139	5	to	to	IN
cord-003921-8r8z0otz	139	6	tissue	tissue	NN
cord-003921-8r8z0otz	139	7	-	-	HYPH
cord-003921-8r8z0otz	139	8	repairing	repair	VBG
cord-003921-8r8z0otz	139	9	processes	process	NNS
cord-003921-8r8z0otz	139	10	following	follow	VBG
cord-003921-8r8z0otz	139	11	infectious	infectious	JJ
cord-003921-8r8z0otz	139	12	or	or	CC
cord-003921-8r8z0otz	139	13	sterile	sterile	JJ
cord-003921-8r8z0otz	139	14	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	139	15	organ	organ	NN
cord-003921-8r8z0otz	139	16	damage	damage	NN
cord-003921-8r8z0otz	139	17	[	[	-LRB-
cord-003921-8r8z0otz	139	18	81	81	CD
cord-003921-8r8z0otz	139	19	]	]	-RRB-
cord-003921-8r8z0otz	139	20	.	.	.
cord-003921-8r8z0otz	140	1	Clinical	clinical	JJ
cord-003921-8r8z0otz	140	2	observations	observation	NNS
cord-003921-8r8z0otz	140	3	support	support	VBP
cord-003921-8r8z0otz	140	4	this	this	DT
cord-003921-8r8z0otz	140	5	concept	concept	NN
cord-003921-8r8z0otz	140	6	,	,	,
cord-003921-8r8z0otz	140	7	as	as	IN
cord-003921-8r8z0otz	140	8	patients	patient	NNS
cord-003921-8r8z0otz	140	9	with	with	IN
cord-003921-8r8z0otz	140	10	leukocyte	leukocyte	NN
cord-003921-8r8z0otz	140	11	adhesion	adhesion	NN
cord-003921-8r8z0otz	140	12	deficiency	deficiency	NN
cord-003921-8r8z0otz	140	13	type	type	NN
cord-003921-8r8z0otz	140	14	1	1	CD
cord-003921-8r8z0otz	140	15	(	(	-LRB-
cord-003921-8r8z0otz	140	16	an	an	DT
cord-003921-8r8z0otz	140	17	autosomal	autosomal	JJ
cord-003921-8r8z0otz	140	18	recessive	recessive	JJ
cord-003921-8r8z0otz	140	19	disorder	disorder	NN
cord-003921-8r8z0otz	140	20	characterized	characterize	VBN
cord-003921-8r8z0otz	140	21	by	by	IN
cord-003921-8r8z0otz	140	22	defects	defect	NNS
cord-003921-8r8z0otz	140	23	in	in	IN
cord-003921-8r8z0otz	140	24	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	140	25	adhesion	adhesion	NN
cord-003921-8r8z0otz	140	26	ability	ability	NN
cord-003921-8r8z0otz	140	27	)	)	-RRB-
cord-003921-8r8z0otz	140	28	experience	experience	NN
cord-003921-8r8z0otz	140	29	delayed	delay	VBN
cord-003921-8r8z0otz	140	30	wound	wound	NN
cord-003921-8r8z0otz	140	31	healing	heal	VBG
cord-003921-8r8z0otz	140	32	[	[	-LRB-
cord-003921-8r8z0otz	140	33	82	82	CD
cord-003921-8r8z0otz	140	34	]	]	-RRB-
cord-003921-8r8z0otz	140	35	.	.	.
cord-003921-8r8z0otz	141	1	In	in	IN
cord-003921-8r8z0otz	141	2	the	the	DT
cord-003921-8r8z0otz	141	3	beginning	beginning	NN
cord-003921-8r8z0otz	141	4	of	of	IN
cord-003921-8r8z0otz	141	5	tissue	tissue	NN
cord-003921-8r8z0otz	141	6	repair	repair	NN
cord-003921-8r8z0otz	141	7	process	process	NN
cord-003921-8r8z0otz	141	8	,	,	,
cord-003921-8r8z0otz	141	9	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	141	10	acting	act	VBG
cord-003921-8r8z0otz	141	11	as	as	IN
cord-003921-8r8z0otz	141	12	professional	professional	JJ
cord-003921-8r8z0otz	141	13	phagocytes	phagocyte	NNS
cord-003921-8r8z0otz	141	14	remove	remove	VBP
cord-003921-8r8z0otz	141	15	tissue	tissue	NN
cord-003921-8r8z0otz	141	16	debris	debris	NN
cord-003921-8r8z0otz	141	17	.	.	.
cord-003921-8r8z0otz	142	1	Indeed	indeed	RB
cord-003921-8r8z0otz	142	2	,	,	,
cord-003921-8r8z0otz	142	3	in	in	IN
cord-003921-8r8z0otz	142	4	a	a	DT
cord-003921-8r8z0otz	142	5	thermal	thermal	JJ
cord-003921-8r8z0otz	142	6	hepatic	hepatic	JJ
cord-003921-8r8z0otz	142	7	injury	injury	NN
cord-003921-8r8z0otz	142	8	model	model	NN
cord-003921-8r8z0otz	142	9	,	,	,
cord-003921-8r8z0otz	142	10	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	142	11	depletion	depletion	NN
cord-003921-8r8z0otz	142	12	resulted	result	VBD
cord-003921-8r8z0otz	142	13	in	in	IN
cord-003921-8r8z0otz	142	14	far	far	RB
cord-003921-8r8z0otz	142	15	more	more	JJR
cord-003921-8r8z0otz	142	16	debris	debris	NN
cord-003921-8r8z0otz	142	17	remaining	remain	VBG
cord-003921-8r8z0otz	142	18	at	at	IN
cord-003921-8r8z0otz	142	19	the	the	DT
cord-003921-8r8z0otz	142	20	injury	injury	NN
cord-003921-8r8z0otz	142	21	site	site	NN
cord-003921-8r8z0otz	142	22	[	[	-LRB-
cord-003921-8r8z0otz	142	23	83•	83•	NNP
cord-003921-8r8z0otz	142	24	]	]	-RRB-
cord-003921-8r8z0otz	142	25	.	.	.
cord-003921-8r8z0otz	143	1	Next	next	RB
cord-003921-8r8z0otz	143	2	,	,	,
cord-003921-8r8z0otz	143	3	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	143	4	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	143	5	shifts	shift	VBZ
cord-003921-8r8z0otz	143	6	the	the	DT
cord-003921-8r8z0otz	143	7	phagocytosing	phagocytosing	NN
cord-003921-8r8z0otz	143	8	macrophages	macrophage	NNS
cord-003921-8r8z0otz	143	9	to	to	IN
cord-003921-8r8z0otz	143	10	the	the	DT
cord-003921-8r8z0otz	143	11	resolution	resolution	NN
cord-003921-8r8z0otz	143	12	phase	phase	NN
cord-003921-8r8z0otz	143	13	(	(	-LRB-
cord-003921-8r8z0otz	143	14	M2	M2	NNP
cord-003921-8r8z0otz	143	15	)	)	-RRB-
cord-003921-8r8z0otz	143	16	,	,	,
cord-003921-8r8z0otz	143	17	which	which	WDT
cord-003921-8r8z0otz	143	18	governs	govern	VBZ
cord-003921-8r8z0otz	143	19	tissue	tissue	NN
cord-003921-8r8z0otz	143	20	-	-	HYPH
cord-003921-8r8z0otz	143	21	repairing	repair	VBG
cord-003921-8r8z0otz	143	22	environment	environment	NN
cord-003921-8r8z0otz	143	23	.	.	.
cord-003921-8r8z0otz	144	1	M2	M2	NNP
cord-003921-8r8z0otz	144	2	macrophages	macrophage	NNS
cord-003921-8r8z0otz	144	3	secrete	secrete	VBP
cord-003921-8r8z0otz	144	4	IL1Ra	IL1Ra	NNP
cord-003921-8r8z0otz	144	5	,	,	,
cord-003921-8r8z0otz	144	6	IL10	IL10	NNP
cord-003921-8r8z0otz	144	7	,	,	,
cord-003921-8r8z0otz	144	8	TGFβ	TGFβ	NNP
cord-003921-8r8z0otz	144	9	,	,	,
cord-003921-8r8z0otz	144	10	and	and	CC
cord-003921-8r8z0otz	144	11	VEGF	VEGF	NNP
cord-003921-8r8z0otz	144	12	,	,	,
cord-003921-8r8z0otz	144	13	leading	lead	VBG
cord-003921-8r8z0otz	144	14	to	to	IN
cord-003921-8r8z0otz	144	15	fibroblast	fibroblast	JJ
cord-003921-8r8z0otz	144	16	differentiation	differentiation	NN
cord-003921-8r8z0otz	144	17	into	into	IN
cord-003921-8r8z0otz	144	18	myofibroblasts	myofibroblast	NNS
cord-003921-8r8z0otz	144	19	,	,	,
cord-003921-8r8z0otz	144	20	synthesis	synthesis	NN
cord-003921-8r8z0otz	144	21	of	of	IN
cord-003921-8r8z0otz	144	22	interstitial	interstitial	NNP
cord-003921-8r8z0otz	144	23	fibrillar	fibrillar	NNP
cord-003921-8r8z0otz	144	24	collagens	collagen	NNS
cord-003921-8r8z0otz	144	25	by	by	IN
cord-003921-8r8z0otz	144	26	myofibroblasts	myofibroblast	NNS
cord-003921-8r8z0otz	144	27	,	,	,
cord-003921-8r8z0otz	144	28	and	and	CC
cord-003921-8r8z0otz	144	29	expression	expression	NN
cord-003921-8r8z0otz	144	30	of	of	IN
cord-003921-8r8z0otz	144	31	MMPs	mmp	NNS
cord-003921-8r8z0otz	144	32	/	/	SYM
cord-003921-8r8z0otz	144	33	TIMPs	TIMPs	NNP
cord-003921-8r8z0otz	144	34	that	that	WDT
cord-003921-8r8z0otz	144	35	control	control	VBP
cord-003921-8r8z0otz	144	36	ECM	ECM	NNP
cord-003921-8r8z0otz	144	37	turnover	turnover	NN
cord-003921-8r8z0otz	144	38	[	[	-LRB-
cord-003921-8r8z0otz	144	39	84	84	CD
cord-003921-8r8z0otz	144	40	]	]	-RRB-
cord-003921-8r8z0otz	144	41	.	.	.
cord-003921-8r8z0otz	145	1	Since	since	IN
cord-003921-8r8z0otz	145	2	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	145	3	can	can	MD
cord-003921-8r8z0otz	145	4	release	release	VB
cord-003921-8r8z0otz	145	5	MMP9	MMP9	NNP
cord-003921-8r8z0otz	145	6	free	free	JJ
cord-003921-8r8z0otz	145	7	of	of	IN
cord-003921-8r8z0otz	145	8	its	-PRON-	PRP$
cord-003921-8r8z0otz	145	9	endogenous	endogenous	JJ
cord-003921-8r8z0otz	145	10	inhibitors	inhibitor	NNS
cord-003921-8r8z0otz	145	11	(	(	-LRB-
cord-003921-8r8z0otz	145	12	TIMPs	TIMPs	NNP
cord-003921-8r8z0otz	145	13	)	)	-RRB-
cord-003921-8r8z0otz	145	14	,	,	,
cord-003921-8r8z0otz	145	15	they	-PRON-	PRP
cord-003921-8r8z0otz	145	16	are	be	VBP
cord-003921-8r8z0otz	145	17	capable	capable	JJ
cord-003921-8r8z0otz	145	18	of	of	IN
cord-003921-8r8z0otz	145	19	delivering	deliver	VBG
cord-003921-8r8z0otz	145	20	highly	highly	RB
cord-003921-8r8z0otz	145	21	active	active	JJ
cord-003921-8r8z0otz	145	22	MMP9	MMP9	NNP
cord-003921-8r8z0otz	145	23	,	,	,
cord-003921-8r8z0otz	145	24	a	a	DT
cord-003921-8r8z0otz	145	25	key	key	JJ
cord-003921-8r8z0otz	145	26	proangiogenic	proangiogenic	NN
cord-003921-8r8z0otz	145	27	factor	factor	NN
cord-003921-8r8z0otz	145	28	degrading	degrade	VBG
cord-003921-8r8z0otz	145	29	ECM	ECM	NNP
cord-003921-8r8z0otz	145	30	,	,	,
cord-003921-8r8z0otz	145	31	to	to	TO
cord-003921-8r8z0otz	145	32	release	release	VB
cord-003921-8r8z0otz	145	33	ECM	ECM	NNP
cord-003921-8r8z0otz	145	34	-	-	HYPH
cord-003921-8r8z0otz	145	35	bounded	bound	VBN
cord-003921-8r8z0otz	145	36	VEGF	VEGF	NNP
cord-003921-8r8z0otz	145	37	and	and	CC
cord-003921-8r8z0otz	145	38	other	other	JJ
cord-003921-8r8z0otz	145	39	growth	growth	NN
cord-003921-8r8z0otz	145	40	factors	factor	NNS
cord-003921-8r8z0otz	145	41	[	[	-LRB-
cord-003921-8r8z0otz	145	42	85	85	CD
cord-003921-8r8z0otz	145	43	]	]	-RRB-
cord-003921-8r8z0otz	145	44	.	.	.
cord-003921-8r8z0otz	146	1	A	a	DT
cord-003921-8r8z0otz	146	2	series	series	NN
cord-003921-8r8z0otz	146	3	of	of	IN
cord-003921-8r8z0otz	146	4	recent	recent	JJ
cord-003921-8r8z0otz	146	5	studies	study	NNS
cord-003921-8r8z0otz	146	6	have	have	VBP
cord-003921-8r8z0otz	146	7	deepened	deepen	VBN
cord-003921-8r8z0otz	146	8	our	-PRON-	PRP$
cord-003921-8r8z0otz	146	9	understanding	understanding	NN
cord-003921-8r8z0otz	146	10	of	of	IN
cord-003921-8r8z0otz	146	11	that	that	DT
cord-003921-8r8z0otz	146	12	process	process	NN
cord-003921-8r8z0otz	146	13	.	.	.
cord-003921-8r8z0otz	147	1	For	for	IN
cord-003921-8r8z0otz	147	2	instance	instance	NN
cord-003921-8r8z0otz	147	3	,	,	,
cord-003921-8r8z0otz	147	4	Christoffersson	Christoffersson	NNP
cord-003921-8r8z0otz	147	5	et	et	NNP
cord-003921-8r8z0otz	147	6	al	al	NNP
cord-003921-8r8z0otz	147	7	.	.	NNP
cord-003921-8r8z0otz	147	8	identified	identify	VBD
cord-003921-8r8z0otz	147	9	a	a	DT
cord-003921-8r8z0otz	147	10	CD11b+/Gr1+/CXCR4	CD11b+/Gr1+/CXCR4	NNP
cord-003921-8r8z0otz	147	11	high	high	JJ
cord-003921-8r8z0otz	147	12	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	147	13	subset	subset	VBN
cord-003921-8r8z0otz	147	14	in	in	IN
cord-003921-8r8z0otz	147	15	a	a	DT
cord-003921-8r8z0otz	147	16	syngeneic	syngeneic	NNS
cord-003921-8r8z0otz	147	17	mouse	mouse	NN
cord-003921-8r8z0otz	147	18	pancreatic	pancreatic	JJ
cord-003921-8r8z0otz	147	19	islet	islet	NN
cord-003921-8r8z0otz	147	20	transplant	transplant	NN
cord-003921-8r8z0otz	147	21	model	model	NN
cord-003921-8r8z0otz	147	22	,	,	,
cord-003921-8r8z0otz	147	23	which	which	WDT
cord-003921-8r8z0otz	147	24	was	be	VBD
cord-003921-8r8z0otz	147	25	recruited	recruit	VBN
cord-003921-8r8z0otz	147	26	via	via	IN
cord-003921-8r8z0otz	147	27	VEGF	VEGF	NNP
cord-003921-8r8z0otz	147	28	-	-	HYPH
cord-003921-8r8z0otz	147	29	A	a	DT
cord-003921-8r8z0otz	147	30	depending	depend	VBG
cord-003921-8r8z0otz	147	31	pathway	pathway	NN
cord-003921-8r8z0otz	147	32	.	.	.
cord-003921-8r8z0otz	148	1	It	-PRON-	PRP
cord-003921-8r8z0otz	148	2	contained	contain	VBD
cord-003921-8r8z0otz	148	3	higher	high	JJR
cord-003921-8r8z0otz	148	4	amount	amount	NN
cord-003921-8r8z0otz	148	5	of	of	IN
cord-003921-8r8z0otz	148	6	MMP9	MMP9	NNP
cord-003921-8r8z0otz	148	7	than	than	IN
cord-003921-8r8z0otz	148	8	those	those	DT
cord-003921-8r8z0otz	148	9	recruited	recruit	VBN
cord-003921-8r8z0otz	148	10	to	to	IN
cord-003921-8r8z0otz	148	11	an	an	DT
cord-003921-8r8z0otz	148	12	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	148	13	stimulus	stimulus	NN
cord-003921-8r8z0otz	148	14	,	,	,
cord-003921-8r8z0otz	148	15	and	and	CC
cord-003921-8r8z0otz	148	16	contributed	contribute	VBD
cord-003921-8r8z0otz	148	17	to	to	IN
cord-003921-8r8z0otz	148	18	revascularization	revascularization	NN
cord-003921-8r8z0otz	148	19	via	via	IN
cord-003921-8r8z0otz	148	20	MMP9	MMP9	NNP
cord-003921-8r8z0otz	148	21	dependent	dependent	JJ
cord-003921-8r8z0otz	148	22	mechanism	mechanism	NN
cord-003921-8r8z0otz	148	23	[	[	-LRB-
cord-003921-8r8z0otz	148	24	86	86	CD
cord-003921-8r8z0otz	148	25	]	]	-RRB-
cord-003921-8r8z0otz	148	26	.	.	.
cord-003921-8r8z0otz	149	1	They	-PRON-	PRP
cord-003921-8r8z0otz	149	2	also	also	RB
cord-003921-8r8z0otz	149	3	found	find	VBD
cord-003921-8r8z0otz	149	4	an	an	DT
cord-003921-8r8z0otz	149	5	analogous	analogous	JJ
cord-003921-8r8z0otz	149	6	CD49d+/VEGFR1	CD49d+/VEGFR1	NNP
cord-003921-8r8z0otz	149	7	high	high	RB
cord-003921-8r8z0otz	149	8	/CXCR4	/CXCR4	.
cord-003921-8r8z0otz	150	1	high	high	JJ
cord-003921-8r8z0otz	150	2	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	150	3	population	population	NN
cord-003921-8r8z0otz	150	4	in	in	IN
cord-003921-8r8z0otz	150	5	mouse	mouse	NN
cord-003921-8r8z0otz	150	6	and	and	CC
cord-003921-8r8z0otz	150	7	human	human	NN
cord-003921-8r8z0otz	150	8	,	,	,
cord-003921-8r8z0otz	150	9	which	which	WDT
cord-003921-8r8z0otz	150	10	was	be	VBD
cord-003921-8r8z0otz	150	11	recruited	recruit	VBN
cord-003921-8r8z0otz	150	12	by	by	IN
cord-003921-8r8z0otz	150	13	hypoxia	hypoxia	NN
cord-003921-8r8z0otz	150	14	-	-	HYPH
cord-003921-8r8z0otz	150	15	induced	induce	VBN
cord-003921-8r8z0otz	150	16	VEGF	VEGF	NNP
cord-003921-8r8z0otz	150	17	-	-	:
cord-003921-8r8z0otz	150	18	A	A	NNP
cord-003921-8r8z0otz	150	19	[	[	-LRB-
cord-003921-8r8z0otz	150	20	87	87	CD
cord-003921-8r8z0otz	150	21	]	]	-RRB-
cord-003921-8r8z0otz	150	22	.	.	.
cord-003921-8r8z0otz	151	1	In	in	IN
cord-003921-8r8z0otz	151	2	a	a	DT
cord-003921-8r8z0otz	151	3	liver	liver	NN
cord-003921-8r8z0otz	151	4	thermal	thermal	JJ
cord-003921-8r8z0otz	151	5	injury	injury	NN
cord-003921-8r8z0otz	151	6	model	model	NN
cord-003921-8r8z0otz	151	7	,	,	,
cord-003921-8r8z0otz	151	8	limited	limited	JJ
cord-003921-8r8z0otz	151	9	period	period	NN
cord-003921-8r8z0otz	151	10	of	of	IN
cord-003921-8r8z0otz	151	11	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	151	12	depletion	depletion	NN
cord-003921-8r8z0otz	151	13	(	(	-LRB-
cord-003921-8r8z0otz	151	14	~48	~48	NFP
cord-003921-8r8z0otz	151	15	h	h	NNP
cord-003921-8r8z0otz	151	16	)	)	-RRB-
cord-003921-8r8z0otz	151	17	resulted	result	VBD
cord-003921-8r8z0otz	151	18	in	in	IN
cord-003921-8r8z0otz	151	19	delayed	delay	VBN
cord-003921-8r8z0otz	151	20	revascularization	revascularization	NN
cord-003921-8r8z0otz	151	21	at	at	IN
cord-003921-8r8z0otz	151	22	7	7	CD
cord-003921-8r8z0otz	151	23	days	day	NNS
cord-003921-8r8z0otz	151	24	and	and	CC
cord-003921-8r8z0otz	151	25	the	the	DT
cord-003921-8r8z0otz	151	26	presence	presence	NN
cord-003921-8r8z0otz	151	27	of	of	IN
cord-003921-8r8z0otz	151	28	non	non	JJ
cord-003921-8r8z0otz	151	29	-	-	JJ
cord-003921-8r8z0otz	151	30	healing	healing	JJ
cord-003921-8r8z0otz	151	31	injury	injury	NN
cord-003921-8r8z0otz	151	32	area	area	NN
cord-003921-8r8z0otz	151	33	at	at	IN
cord-003921-8r8z0otz	151	34	4	4	CD
cord-003921-8r8z0otz	151	35	weeks	week	NNS
cord-003921-8r8z0otz	151	36	,	,	,
cord-003921-8r8z0otz	151	37	suggesting	suggest	VBG
cord-003921-8r8z0otz	151	38	the	the	DT
cord-003921-8r8z0otz	151	39	requirement	requirement	NN
cord-003921-8r8z0otz	151	40	for	for	IN
cord-003921-8r8z0otz	151	41	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	151	42	in	in	IN
cord-003921-8r8z0otz	151	43	liver	liver	NN
cord-003921-8r8z0otz	151	44	homeostasis	homeostasis	NN
cord-003921-8r8z0otz	151	45	[	[	-LRB-
cord-003921-8r8z0otz	151	46	83•	83•	NNP
cord-003921-8r8z0otz	151	47	]	]	-RRB-
cord-003921-8r8z0otz	151	48	.	.	.
cord-003921-8r8z0otz	152	1	Likewise	likewise	RB
cord-003921-8r8z0otz	152	2	,	,	,
cord-003921-8r8z0otz	152	3	in	in	IN
cord-003921-8r8z0otz	152	4	a	a	DT
cord-003921-8r8z0otz	152	5	transplantation	transplantation	NN
cord-003921-8r8z0otz	152	6	model	model	NN
cord-003921-8r8z0otz	152	7	of	of	IN
cord-003921-8r8z0otz	152	8	bioengineered	bioengineere	VBN
cord-003921-8r8z0otz	152	9	U	u	NN
cord-003921-8r8z0otz	152	10	-	-	HYPH
cord-003921-8r8z0otz	152	11	graft	graft	NN
cord-003921-8r8z0otz	152	12	,	,	,
cord-003921-8r8z0otz	152	13	which	which	WDT
cord-003921-8r8z0otz	152	14	contained	contain	VBD
cord-003921-8r8z0otz	152	15	an	an	DT
cord-003921-8r8z0otz	152	16	unassembled	unassembled	JJ
cord-003921-8r8z0otz	152	17	suspension	suspension	NN
cord-003921-8r8z0otz	152	18	of	of	IN
cord-003921-8r8z0otz	152	19	vascular	vascular	JJ
cord-003921-8r8z0otz	152	20	cells	cell	NNS
cord-003921-8r8z0otz	152	21	embedded	embed	VBN
cord-003921-8r8z0otz	152	22	in	in	IN
cord-003921-8r8z0otz	152	23	a	a	DT
cord-003921-8r8z0otz	152	24	hydrogel	hydrogel	NN
cord-003921-8r8z0otz	152	25	,	,	,
cord-003921-8r8z0otz	152	26	host	host	NN
cord-003921-8r8z0otz	152	27	-	-	HYPH
cord-003921-8r8z0otz	152	28	derived	derive	VBN
cord-003921-8r8z0otz	152	29	alternatively	alternatively	RB
cord-003921-8r8z0otz	152	30	polarized	polarized	JJ
cord-003921-8r8z0otz	152	31	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	152	32	(	(	-LRB-
cord-003921-8r8z0otz	152	33	N2	N2	NNP
cord-003921-8r8z0otz	152	34	)	)	-RRB-
cord-003921-8r8z0otz	152	35	contributed	contribute	VBD
cord-003921-8r8z0otz	152	36	to	to	TO
cord-003921-8r8z0otz	152	37	graft	graft	VB
cord-003921-8r8z0otz	152	38	revascularization	revascularization	NN
cord-003921-8r8z0otz	152	39	[	[	-LRB-
cord-003921-8r8z0otz	152	40	88•	88•	CD
cord-003921-8r8z0otz	152	41	]	]	-RRB-
cord-003921-8r8z0otz	152	42	.	.	.
cord-003921-8r8z0otz	153	1	In	in	IN
cord-003921-8r8z0otz	153	2	a	a	DT
cord-003921-8r8z0otz	153	3	successful	successful	JJ
cord-003921-8r8z0otz	153	4	response	response	NN
cord-003921-8r8z0otz	153	5	to	to	IN
cord-003921-8r8z0otz	153	6	an	an	DT
cord-003921-8r8z0otz	153	7	acute	acute	JJ
cord-003921-8r8z0otz	153	8	injury	injury	NN
cord-003921-8r8z0otz	153	9	,	,	,
cord-003921-8r8z0otz	153	10	it	-PRON-	PRP
cord-003921-8r8z0otz	153	11	is	be	VBZ
cord-003921-8r8z0otz	153	12	crucial	crucial	JJ
cord-003921-8r8z0otz	153	13	to	to	TO
cord-003921-8r8z0otz	153	14	prevent	prevent	VB
cord-003921-8r8z0otz	153	15	tissue	tissue	NN
cord-003921-8r8z0otz	153	16	damage	damage	NN
cord-003921-8r8z0otz	153	17	by	by	IN
cord-003921-8r8z0otz	153	18	promoting	promote	VBG
cord-003921-8r8z0otz	153	19	the	the	DT
cord-003921-8r8z0otz	153	20	local	local	JJ
cord-003921-8r8z0otz	153	21	resolution	resolution	NN
cord-003921-8r8z0otz	153	22	of	of	IN
cord-003921-8r8z0otz	153	23	inflammation	inflammation	NN
cord-003921-8r8z0otz	153	24	through	through	IN
cord-003921-8r8z0otz	153	25	the	the	DT
cord-003921-8r8z0otz	153	26	removal	removal	NN
cord-003921-8r8z0otz	153	27	of	of	IN
cord-003921-8r8z0otz	153	28	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	153	29	from	from	IN
cord-003921-8r8z0otz	153	30	the	the	DT
cord-003921-8r8z0otz	153	31	stressed	stress	VBN
cord-003921-8r8z0otz	153	32	site	site	NN
cord-003921-8r8z0otz	153	33	[	[	-LRB-
cord-003921-8r8z0otz	153	34	89	89	CD
cord-003921-8r8z0otz	153	35	]	]	-RRB-
cord-003921-8r8z0otz	153	36	.	.	.
cord-003921-8r8z0otz	154	1	Apoptosis	apoptosis	NN
cord-003921-8r8z0otz	154	2	,	,	,
cord-003921-8r8z0otz	154	3	a	a	DT
cord-003921-8r8z0otz	154	4	highly	highly	RB
cord-003921-8r8z0otz	154	5	organized	organize	VBN
cord-003921-8r8z0otz	154	6	programmed	programmed	JJ
cord-003921-8r8z0otz	154	7	cell	cell	NN
cord-003921-8r8z0otz	154	8	death	death	NN
cord-003921-8r8z0otz	154	9	program	program	NN
cord-003921-8r8z0otz	154	10	,	,	,
cord-003921-8r8z0otz	154	11	is	be	VBZ
cord-003921-8r8z0otz	154	12	considered	consider	VBN
cord-003921-8r8z0otz	154	13	a	a	DT
cord-003921-8r8z0otz	154	14	favorable	favorable	JJ
cord-003921-8r8z0otz	154	15	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	154	16	death	death	NN
cord-003921-8r8z0otz	154	17	mechanism	mechanism	NN
cord-003921-8r8z0otz	154	18	because	because	IN
cord-003921-8r8z0otz	154	19	the	the	DT
cord-003921-8r8z0otz	154	20	orderly	orderly	JJ
cord-003921-8r8z0otz	154	21	cell	cell	NN
cord-003921-8r8z0otz	154	22	elimination	elimination	NN
cord-003921-8r8z0otz	154	23	limits	limit	NNS
cord-003921-8r8z0otz	154	24	uncontrolled	uncontrolled	JJ
cord-003921-8r8z0otz	154	25	release	release	NN
cord-003921-8r8z0otz	154	26	of	of	IN
cord-003921-8r8z0otz	154	27	toxic	toxic	JJ
cord-003921-8r8z0otz	154	28	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	154	29	contents	content	NNS
cord-003921-8r8z0otz	154	30	and	and	CC
cord-003921-8r8z0otz	154	31	DAMPs	damp	NNS
cord-003921-8r8z0otz	154	32	,	,	,
cord-003921-8r8z0otz	154	33	which	which	WDT
cord-003921-8r8z0otz	154	34	potentially	potentially	RB
cord-003921-8r8z0otz	154	35	may	may	MD
cord-003921-8r8z0otz	154	36	cause	cause	VB
cord-003921-8r8z0otz	154	37	further	further	JJ
cord-003921-8r8z0otz	154	38	tissue	tissue	NN
cord-003921-8r8z0otz	154	39	damage	damage	NN
cord-003921-8r8z0otz	154	40	[	[	-LRB-
cord-003921-8r8z0otz	154	41	90	90	CD
cord-003921-8r8z0otz	154	42	]	]	-RRB-
cord-003921-8r8z0otz	154	43	.	.	.
cord-003921-8r8z0otz	155	1	Morphologically	morphologically	RB
cord-003921-8r8z0otz	155	2	,	,	,
cord-003921-8r8z0otz	155	3	apoptotic	apoptotic	JJ
cord-003921-8r8z0otz	155	4	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	155	5	show	show	VBP
cord-003921-8r8z0otz	155	6	the	the	DT
cord-003921-8r8z0otz	155	7	condensation	condensation	NN
cord-003921-8r8z0otz	155	8	of	of	IN
cord-003921-8r8z0otz	155	9	chromatin	chromatin	NN
cord-003921-8r8z0otz	155	10	and	and	CC
cord-003921-8r8z0otz	155	11	its	-PRON-	PRP$
cord-003921-8r8z0otz	155	12	migration	migration	NN
cord-003921-8r8z0otz	155	13	to	to	IN
cord-003921-8r8z0otz	155	14	the	the	DT
cord-003921-8r8z0otz	155	15	nuclear	nuclear	JJ
cord-003921-8r8z0otz	155	16	periphery	periphery	NN
cord-003921-8r8z0otz	155	17	,	,	,
cord-003921-8r8z0otz	155	18	fragmentation	fragmentation	NN
cord-003921-8r8z0otz	155	19	of	of	IN
cord-003921-8r8z0otz	155	20	nuclear	nuclear	JJ
cord-003921-8r8z0otz	155	21	DNA	dna	NN
cord-003921-8r8z0otz	155	22	,	,	,
cord-003921-8r8z0otz	155	23	and	and	CC
cord-003921-8r8z0otz	155	24	the	the	DT
cord-003921-8r8z0otz	155	25	blebbing	blebbing	NN
cord-003921-8r8z0otz	155	26	of	of	IN
cord-003921-8r8z0otz	155	27	cell	cell	NN
cord-003921-8r8z0otz	155	28	membranes	membrane	NNS
cord-003921-8r8z0otz	155	29	leading	lead	VBG
cord-003921-8r8z0otz	155	30	to	to	IN
cord-003921-8r8z0otz	155	31	apoptotic	apoptotic	JJ
cord-003921-8r8z0otz	155	32	body	body	NN
cord-003921-8r8z0otz	155	33	formation	formation	NN
cord-003921-8r8z0otz	155	34	.	.	.
cord-003921-8r8z0otz	156	1	As	as	IN
cord-003921-8r8z0otz	156	2	discussed	discuss	VBN
cord-003921-8r8z0otz	156	3	,	,	,
cord-003921-8r8z0otz	156	4	engulfment	engulfment	NN
cord-003921-8r8z0otz	156	5	of	of	IN
cord-003921-8r8z0otz	156	6	apoptotic	apoptotic	JJ
cord-003921-8r8z0otz	156	7	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	156	8	by	by	IN
cord-003921-8r8z0otz	156	9	macrophages	macrophage	NNS
cord-003921-8r8z0otz	156	10	occurs	occur	VBZ
cord-003921-8r8z0otz	156	11	in	in	IN
cord-003921-8r8z0otz	156	12	the	the	DT
cord-003921-8r8z0otz	156	13	resolution	resolution	NN
cord-003921-8r8z0otz	156	14	phase	phase	NN
cord-003921-8r8z0otz	156	15	of	of	IN
cord-003921-8r8z0otz	156	16	inflammation	inflammation	NN
cord-003921-8r8z0otz	156	17	and	and	CC
cord-003921-8r8z0otz	156	18	repair	repair	NN
cord-003921-8r8z0otz	156	19	from	from	IN
cord-003921-8r8z0otz	156	20	tissue	tissue	NN
cord-003921-8r8z0otz	156	21	injury	injury	NN
cord-003921-8r8z0otz	156	22	by	by	IN
cord-003921-8r8z0otz	156	23	turning	turn	VBG
cord-003921-8r8z0otz	156	24	off	off	RP
cord-003921-8r8z0otz	156	25	production	production	NN
cord-003921-8r8z0otz	156	26	of	of	IN
cord-003921-8r8z0otz	156	27	pro	pro	JJ
cord-003921-8r8z0otz	156	28	-	-	JJ
cord-003921-8r8z0otz	156	29	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	156	30	cytokines	cytokine	NNS
cord-003921-8r8z0otz	156	31	and	and	CC
cord-003921-8r8z0otz	156	32	launching	launch	VBG
cord-003921-8r8z0otz	156	33	an	an	DT
cord-003921-8r8z0otz	156	34	anti	anti	JJ
cord-003921-8r8z0otz	156	35	-	-	JJ
cord-003921-8r8z0otz	156	36	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	156	37	transcriptional	transcriptional	JJ
cord-003921-8r8z0otz	156	38	program	program	NN
cord-003921-8r8z0otz	156	39	characterized	characterize	VBN
cord-003921-8r8z0otz	156	40	by	by	IN
cord-003921-8r8z0otz	156	41	the	the	DT
cord-003921-8r8z0otz	156	42	release	release	NN
cord-003921-8r8z0otz	156	43	of	of	IN
cord-003921-8r8z0otz	156	44	IL10	IL10	NNP
cord-003921-8r8z0otz	156	45	and	and	CC
cord-003921-8r8z0otz	156	46	TGFβ	TGFβ	NNP
cord-003921-8r8z0otz	156	47	[	[	-LRB-
cord-003921-8r8z0otz	156	48	84	84	CD
cord-003921-8r8z0otz	156	49	]	]	-RRB-
cord-003921-8r8z0otz	156	50	.	.	.
cord-003921-8r8z0otz	157	1	In	in	IN
cord-003921-8r8z0otz	157	2	contrast	contrast	NN
cord-003921-8r8z0otz	157	3	to	to	IN
cord-003921-8r8z0otz	157	4	the	the	DT
cord-003921-8r8z0otz	157	5	organized	organized	JJ
cord-003921-8r8z0otz	157	6	apoptotic	apoptotic	JJ
cord-003921-8r8z0otz	157	7	cell	cell	NN
cord-003921-8r8z0otz	157	8	death	death	NN
cord-003921-8r8z0otz	157	9	,	,	,
cord-003921-8r8z0otz	157	10	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	157	11	necrosis	necrosis	NN
cord-003921-8r8z0otz	157	12	is	be	VBZ
cord-003921-8r8z0otz	157	13	a	a	DT
cord-003921-8r8z0otz	157	14	traumatic	traumatic	JJ
cord-003921-8r8z0otz	157	15	and	and	CC
cord-003921-8r8z0otz	157	16	highly	highly	RB
cord-003921-8r8z0otz	157	17	detrimental	detrimental	JJ
cord-003921-8r8z0otz	157	18	event	event	NN
cord-003921-8r8z0otz	157	19	resulting	result	VBG
cord-003921-8r8z0otz	157	20	in	in	IN
cord-003921-8r8z0otz	157	21	disintegration	disintegration	NN
cord-003921-8r8z0otz	157	22	of	of	IN
cord-003921-8r8z0otz	157	23	the	the	DT
cord-003921-8r8z0otz	157	24	nuclear	nuclear	JJ
cord-003921-8r8z0otz	157	25	envelope	envelope	NN
cord-003921-8r8z0otz	157	26	and	and	CC
cord-003921-8r8z0otz	157	27	cytoplasmic	cytoplasmic	JJ
cord-003921-8r8z0otz	157	28	membranes	membrane	NNS
cord-003921-8r8z0otz	157	29	.	.	.
cord-003921-8r8z0otz	158	1	Neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	158	2	unavoidably	unavoidably	RB
cord-003921-8r8z0otz	158	3	undergo	undergo	VBP
cord-003921-8r8z0otz	158	4	necrosis	necrosis	NN
cord-003921-8r8z0otz	158	5	if	if	IN
cord-003921-8r8z0otz	158	6	the	the	DT
cord-003921-8r8z0otz	158	7	insult	insult	NN
cord-003921-8r8z0otz	158	8	is	be	VBZ
cord-003921-8r8z0otz	158	9	too	too	RB
cord-003921-8r8z0otz	158	10	severe	severe	JJ
cord-003921-8r8z0otz	158	11	or	or	CC
cord-003921-8r8z0otz	158	12	the	the	DT
cord-003921-8r8z0otz	158	13	step	step	NN
cord-003921-8r8z0otz	158	14	-	-	HYPH
cord-003921-8r8z0otz	158	15	by	by	IN
cord-003921-8r8z0otz	158	16	-	-	HYPH
cord-003921-8r8z0otz	158	17	step	step	NN
cord-003921-8r8z0otz	158	18	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	158	19	procedure	procedure	NN
cord-003921-8r8z0otz	158	20	fails	fail	VBZ
cord-003921-8r8z0otz	158	21	to	to	TO
cord-003921-8r8z0otz	158	22	be	be	VB
cord-003921-8r8z0otz	158	23	achieved	achieve	VBN
cord-003921-8r8z0otz	158	24	in	in	IN
cord-003921-8r8z0otz	158	25	a	a	DT
cord-003921-8r8z0otz	158	26	timely	timely	JJ
cord-003921-8r8z0otz	158	27	fashion	fashion	NN
cord-003921-8r8z0otz	158	28	,	,	,
cord-003921-8r8z0otz	158	29	a	a	DT
cord-003921-8r8z0otz	158	30	process	process	NN
cord-003921-8r8z0otz	158	31	called	call	VBN
cord-003921-8r8z0otz	158	32	a	a	DT
cord-003921-8r8z0otz	158	33	"	"	``
cord-003921-8r8z0otz	158	34	secondary	secondary	JJ
cord-003921-8r8z0otz	158	35	necrosis	necrosis	NN
cord-003921-8r8z0otz	158	36	.	.	.
cord-003921-8r8z0otz	159	1	"	"	''
cord-003921-8r8z0otz	160	1	Necrotic	necrotic	JJ
cord-003921-8r8z0otz	160	2	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	160	3	passively	passively	RB
cord-003921-8r8z0otz	160	4	releases	release	VBZ
cord-003921-8r8z0otz	160	5	toxic	toxic	JJ
cord-003921-8r8z0otz	160	6	effector	effector	NN
cord-003921-8r8z0otz	160	7	molecules	molecule	NNS
cord-003921-8r8z0otz	160	8	as	as	RB
cord-003921-8r8z0otz	160	9	well	well	RB
cord-003921-8r8z0otz	160	10	as	as	IN
cord-003921-8r8z0otz	160	11	DAMPs	damp	NNS
cord-003921-8r8z0otz	160	12	leading	lead	VBG
cord-003921-8r8z0otz	160	13	to	to	IN
cord-003921-8r8z0otz	160	14	further	further	JJ
cord-003921-8r8z0otz	160	15	damage	damage	NN
cord-003921-8r8z0otz	160	16	and	and	CC
cord-003921-8r8z0otz	160	17	inflammation	inflammation	NN
cord-003921-8r8z0otz	160	18	in	in	IN
cord-003921-8r8z0otz	160	19	neighboring	neighboring	NN
cord-003921-8r8z0otz	160	20	tissues	tissue	NNS
cord-003921-8r8z0otz	160	21	[	[	-LRB-
cord-003921-8r8z0otz	160	22	90	90	CD
cord-003921-8r8z0otz	160	23	]	]	-RRB-
cord-003921-8r8z0otz	160	24	.	.	.
cord-003921-8r8z0otz	161	1	NETosis	NETosis	NNP
cord-003921-8r8z0otz	161	2	is	be	VBZ
cord-003921-8r8z0otz	161	3	the	the	DT
cord-003921-8r8z0otz	161	4	process	process	NN
cord-003921-8r8z0otz	161	5	by	by	IN
cord-003921-8r8z0otz	161	6	which	which	WDT
cord-003921-8r8z0otz	161	7	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	161	8	produce	produce	VBP
cord-003921-8r8z0otz	161	9	and	and	CC
cord-003921-8r8z0otz	161	10	release	release	VB
cord-003921-8r8z0otz	161	11	NETs	net	NNS
cord-003921-8r8z0otz	161	12	.	.	.
cord-003921-8r8z0otz	162	1	During	during	IN
cord-003921-8r8z0otz	162	2	NETosis	NETosis	NNP
cord-003921-8r8z0otz	162	3	,	,	,
cord-003921-8r8z0otz	162	4	intracellular	intracellular	JJ
cord-003921-8r8z0otz	162	5	proteins	protein	NNS
cord-003921-8r8z0otz	162	6	become	become	VBP
cord-003921-8r8z0otz	162	7	exposed	expose	VBN
cord-003921-8r8z0otz	162	8	to	to	IN
cord-003921-8r8z0otz	162	9	the	the	DT
cord-003921-8r8z0otz	162	10	extracellular	extracellular	JJ
cord-003921-8r8z0otz	162	11	space	space	NN
cord-003921-8r8z0otz	162	12	,	,	,
cord-003921-8r8z0otz	162	13	which	which	WDT
cord-003921-8r8z0otz	162	14	results	result	VBZ
cord-003921-8r8z0otz	162	15	in	in	IN
cord-003921-8r8z0otz	162	16	the	the	DT
cord-003921-8r8z0otz	162	17	potential	potential	JJ
cord-003921-8r8z0otz	162	18	presentation	presentation	NN
cord-003921-8r8z0otz	162	19	of	of	IN
cord-003921-8r8z0otz	162	20	autoantigens	autoantigens	NNP
cord-003921-8r8z0otz	162	21	to	to	IN
cord-003921-8r8z0otz	162	22	the	the	DT
cord-003921-8r8z0otz	162	23	host	host	NN
cord-003921-8r8z0otz	162	24	immune	immune	JJ
cord-003921-8r8z0otz	162	25	system	system	NN
cord-003921-8r8z0otz	162	26	and	and	CC
cord-003921-8r8z0otz	162	27	the	the	DT
cord-003921-8r8z0otz	162	28	release	release	NN
cord-003921-8r8z0otz	162	29	of	of	IN
cord-003921-8r8z0otz	162	30	DAMPs	damp	NNS
cord-003921-8r8z0otz	162	31	that	that	WDT
cord-003921-8r8z0otz	162	32	amplify	amplify	VBP
cord-003921-8r8z0otz	162	33	ongoing	ongoing	JJ
cord-003921-8r8z0otz	162	34	immune	immune	JJ
cord-003921-8r8z0otz	162	35	reactions	reaction	NNS
cord-003921-8r8z0otz	162	36	[	[	-LRB-
cord-003921-8r8z0otz	162	37	53	53	CD
cord-003921-8r8z0otz	162	38	]	]	-RRB-
cord-003921-8r8z0otz	162	39	.	.	.
cord-003921-8r8z0otz	163	1	In	in	IN
cord-003921-8r8z0otz	163	2	this	this	DT
cord-003921-8r8z0otz	163	3	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	163	4	aspect	aspect	NN
cord-003921-8r8z0otz	163	5	,	,	,
cord-003921-8r8z0otz	163	6	the	the	DT
cord-003921-8r8z0otz	163	7	NETosis	NETosis	NNP
cord-003921-8r8z0otz	163	8	seems	seem	VBZ
cord-003921-8r8z0otz	163	9	closer	close	JJR
cord-003921-8r8z0otz	163	10	to	to	IN
cord-003921-8r8z0otz	163	11	necrosis	necrosis	NN
cord-003921-8r8z0otz	163	12	than	than	IN
cord-003921-8r8z0otz	163	13	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	163	14	.	.	.
cord-003921-8r8z0otz	164	1	On	on	IN
cord-003921-8r8z0otz	164	2	the	the	DT
cord-003921-8r8z0otz	164	3	other	other	JJ
cord-003921-8r8z0otz	164	4	hand	hand	NN
cord-003921-8r8z0otz	164	5	,	,	,
cord-003921-8r8z0otz	164	6	the	the	DT
cord-003921-8r8z0otz	164	7	function	function	NN
cord-003921-8r8z0otz	164	8	of	of	IN
cord-003921-8r8z0otz	164	9	NETosis	netosis	NN
cord-003921-8r8z0otz	164	10	to	to	TO
cord-003921-8r8z0otz	164	11	promote	promote	VB
cord-003921-8r8z0otz	164	12	coagulation	coagulation	NN
cord-003921-8r8z0otz	164	13	and	and	CC
cord-003921-8r8z0otz	164	14	thrombosis	thrombosis	NN
cord-003921-8r8z0otz	164	15	have	have	VBP
cord-003921-8r8z0otz	164	16	been	be	VBN
cord-003921-8r8z0otz	164	17	now	now	RB
cord-003921-8r8z0otz	164	18	recognized	recognize	VBN
cord-003921-8r8z0otz	164	19	[	[	-LRB-
cord-003921-8r8z0otz	164	20	91	91	CD
cord-003921-8r8z0otz	164	21	,	,	,
cord-003921-8r8z0otz	164	22	92	92	CD
cord-003921-8r8z0otz	164	23	]	]	-RRB-
cord-003921-8r8z0otz	164	24	,	,	,
cord-003921-8r8z0otz	164	25	whereas	whereas	IN
cord-003921-8r8z0otz	164	26	a	a	DT
cord-003921-8r8z0otz	164	27	recent	recent	JJ
cord-003921-8r8z0otz	164	28	study	study	NN
cord-003921-8r8z0otz	164	29	from	from	IN
cord-003921-8r8z0otz	164	30	McDonald	McDonald	NNP
cord-003921-8r8z0otz	164	31	et	et	NNP
cord-003921-8r8z0otz	164	32	al	al	NNP
cord-003921-8r8z0otz	164	33	.	.	NNP
cord-003921-8r8z0otz	164	34	has	have	VBZ
cord-003921-8r8z0otz	164	35	revealed	reveal	VBN
cord-003921-8r8z0otz	164	36	NET	net	NN
cord-003921-8r8z0otz	164	37	-	-	HYPH
cord-003921-8r8z0otz	164	38	platelet	platelet	NN
cord-003921-8r8z0otz	164	39	-	-	HYPH
cord-003921-8r8z0otz	164	40	thrombin	thrombin	JJ
cord-003921-8r8z0otz	164	41	axis	axis	NN
cord-003921-8r8z0otz	164	42	that	that	WDT
cord-003921-8r8z0otz	164	43	promotes	promote	VBZ
cord-003921-8r8z0otz	164	44	intravascular	intravascular	JJ
cord-003921-8r8z0otz	164	45	coagulation	coagulation	NN
cord-003921-8r8z0otz	164	46	and	and	CC
cord-003921-8r8z0otz	164	47	microvascular	microvascular	JJ
cord-003921-8r8z0otz	164	48	dysfunction	dysfunction	NN
cord-003921-8r8z0otz	164	49	in	in	IN
cord-003921-8r8z0otz	164	50	endotoxin	endotoxin	NN
cord-003921-8r8z0otz	164	51	-	-	HYPH
cord-003921-8r8z0otz	164	52	induced	induce	VBN
cord-003921-8r8z0otz	164	53	liver	liver	NN
cord-003921-8r8z0otz	164	54	injury	injury	NN
cord-003921-8r8z0otz	164	55	model	model	NN
cord-003921-8r8z0otz	164	56	[	[	-LRB-
cord-003921-8r8z0otz	164	57	93•	93•	CD
cord-003921-8r8z0otz	164	58	]	]	-RRB-
cord-003921-8r8z0otz	164	59	.	.	.
cord-003921-8r8z0otz	165	1	Considering	consider	VBG
cord-003921-8r8z0otz	165	2	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	165	3	preferentially	preferentially	RB
cord-003921-8r8z0otz	165	4	undergo	undergo	VBP
cord-003921-8r8z0otz	165	5	necrosis/	necrosis/	CD
cord-003921-8r8z0otz	165	6	NETosis	NETosis	NNP
cord-003921-8r8z0otz	165	7	rather	rather	RB
cord-003921-8r8z0otz	165	8	than	than	IN
cord-003921-8r8z0otz	165	9	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	165	10	if	if	IN
cord-003921-8r8z0otz	165	11	the	the	DT
cord-003921-8r8z0otz	165	12	stress	stress	NN
cord-003921-8r8z0otz	165	13	/	/	SYM
cord-003921-8r8z0otz	165	14	infection	infection	NN
cord-003921-8r8z0otz	165	15	is	be	VBZ
cord-003921-8r8z0otz	165	16	severe	severe	JJ
cord-003921-8r8z0otz	165	17	[	[	-LRB-
cord-003921-8r8z0otz	165	18	94	94	CD
cord-003921-8r8z0otz	165	19	]	]	-RRB-
cord-003921-8r8z0otz	165	20	,	,	,
cord-003921-8r8z0otz	165	21	the	the	DT
cord-003921-8r8z0otz	165	22	function	function	NN
cord-003921-8r8z0otz	165	23	of	of	IN
cord-003921-8r8z0otz	165	24	NETosis	NETosis	NNP
cord-003921-8r8z0otz	165	25	to	to	TO
cord-003921-8r8z0otz	165	26	block	block	VB
cord-003921-8r8z0otz	165	27	blood	blood	NN
cord-003921-8r8z0otz	165	28	flow	flow	NN
cord-003921-8r8z0otz	165	29	to	to	IN
cord-003921-8r8z0otz	165	30	/	/	SYM
cord-003921-8r8z0otz	165	31	from	from	IN
cord-003921-8r8z0otz	165	32	the	the	DT
cord-003921-8r8z0otz	165	33	severely	severely	RB
cord-003921-8r8z0otz	165	34	damaged	damage	VBN
cord-003921-8r8z0otz	165	35	site	site	NN
cord-003921-8r8z0otz	165	36	seems	seem	VBZ
cord-003921-8r8z0otz	165	37	to	to	TO
cord-003921-8r8z0otz	165	38	be	be	VB
cord-003921-8r8z0otz	165	39	favorable	favorable	JJ
cord-003921-8r8z0otz	165	40	by	by	IN
cord-003921-8r8z0otz	165	41	averting	avert	VBG
cord-003921-8r8z0otz	165	42	the	the	DT
cord-003921-8r8z0otz	165	43	spread	spread	NN
cord-003921-8r8z0otz	165	44	of	of	IN
cord-003921-8r8z0otz	165	45	DAMPs	damp	NNS
cord-003921-8r8z0otz	165	46	/	/	SYM
cord-003921-8r8z0otz	165	47	pathogens	pathogen	NNS
cord-003921-8r8z0otz	165	48	to	to	IN
cord-003921-8r8z0otz	165	49	remote	remote	JJ
cord-003921-8r8z0otz	165	50	organs	organ	NNS
cord-003921-8r8z0otz	165	51	and	and	CC
cord-003921-8r8z0otz	165	52	preventing	prevent	VBG
cord-003921-8r8z0otz	165	53	distant	distant	JJ
cord-003921-8r8z0otz	165	54	organ	organ	NN
cord-003921-8r8z0otz	165	55	injury	injury	NN
cord-003921-8r8z0otz	165	56	.	.	.
cord-003921-8r8z0otz	166	1	In	in	IN
cord-003921-8r8z0otz	166	2	this	this	DT
cord-003921-8r8z0otz	166	3	context	context	NN
cord-003921-8r8z0otz	166	4	,	,	,
cord-003921-8r8z0otz	166	5	Nakazawa	Nakazawa	NNP
cord-003921-8r8z0otz	166	6	et	et	FW
cord-003921-8r8z0otz	166	7	al	al	NNP
cord-003921-8r8z0otz	166	8	.	.	NNP
cord-003921-8r8z0otz	166	9	revealed	reveal	VBD
cord-003921-8r8z0otz	166	10	NETs	NETs	NNP
cord-003921-8r8z0otz	166	11	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	166	12	alleviated	alleviate	VBD
cord-003921-8r8z0otz	166	13	acute	acute	JJ
cord-003921-8r8z0otz	166	14	kidney	kidney	NN
cord-003921-8r8z0otz	166	15	injury	injury	NN
cord-003921-8r8z0otz	166	16	while	while	IN
cord-003921-8r8z0otz	166	17	concomitantly	concomitantly	RB
cord-003921-8r8z0otz	166	18	reducing	reduce	VBG
cord-003921-8r8z0otz	166	19	serum	serum	NN
cord-003921-8r8z0otz	166	20	NETs	net	NNS
cord-003921-8r8z0otz	166	21	levels	level	NNS
cord-003921-8r8z0otz	166	22	and	and	CC
cord-003921-8r8z0otz	166	23	mitigating	mitigate	VBG
cord-003921-8r8z0otz	166	24	remote	remote	JJ
cord-003921-8r8z0otz	166	25	organ	organ	NN
cord-003921-8r8z0otz	166	26	injury	injury	NN
cord-003921-8r8z0otz	166	27	in	in	IN
cord-003921-8r8z0otz	166	28	the	the	DT
cord-003921-8r8z0otz	166	29	lung	lung	NN
cord-003921-8r8z0otz	166	30	,	,	,
cord-003921-8r8z0otz	166	31	liver	liver	NN
cord-003921-8r8z0otz	166	32	,	,	,
cord-003921-8r8z0otz	166	33	heart	heart	NN
cord-003921-8r8z0otz	166	34	,	,	,
cord-003921-8r8z0otz	166	35	and	and	CC
cord-003921-8r8z0otz	166	36	brain	brain	NN
cord-003921-8r8z0otz	166	37	[	[	-LRB-
cord-003921-8r8z0otz	166	38	54•	54•	CD
cord-003921-8r8z0otz	166	39	]	]	-RRB-
cord-003921-8r8z0otz	166	40	.	.	.
cord-003921-8r8z0otz	167	1	In	in	IN
cord-003921-8r8z0otz	167	2	contrast	contrast	NN
cord-003921-8r8z0otz	167	3	,	,	,
cord-003921-8r8z0otz	167	4	homozygous	homozygous	JJ
cord-003921-8r8z0otz	167	5	PAD4	PAD4	NNP
cord-003921-8r8z0otz	167	6	knockout	knockout	NN
cord-003921-8r8z0otz	167	7	in	in	IN
cord-003921-8r8z0otz	167	8	MRSA	MRSA	NNP
cord-003921-8r8z0otz	167	9	challenged	challenge	VBD
cord-003921-8r8z0otz	167	10	mice	mouse	NNS
cord-003921-8r8z0otz	167	11	was	be	VBD
cord-003921-8r8z0otz	167	12	accompanied	accompany	VBN
cord-003921-8r8z0otz	167	13	by	by	IN
cord-003921-8r8z0otz	167	14	decreased	decrease	VBN
cord-003921-8r8z0otz	167	15	NETs	net	NNS
cord-003921-8r8z0otz	167	16	and	and	CC
cord-003921-8r8z0otz	167	17	reduced	reduced	JJ
cord-003921-8r8z0otz	167	18	lung	lung	NN
cord-003921-8r8z0otz	167	19	injury	injury	NN
cord-003921-8r8z0otz	167	20	despite	despite	IN
cord-003921-8r8z0otz	167	21	higher	high	JJR
cord-003921-8r8z0otz	167	22	bacterial	bacterial	JJ
cord-003921-8r8z0otz	167	23	counts	count	NNS
cord-003921-8r8z0otz	167	24	,	,	,
cord-003921-8r8z0otz	167	25	increased	increase	VBN
cord-003921-8r8z0otz	167	26	levels	level	NNS
cord-003921-8r8z0otz	167	27	of	of	IN
cord-003921-8r8z0otz	167	28	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	167	29	cytokines	cytokine	NNS
cord-003921-8r8z0otz	167	30	,	,	,
cord-003921-8r8z0otz	167	31	and	and	CC
cord-003921-8r8z0otz	167	32	equivalent	equivalent	JJ
cord-003921-8r8z0otz	167	33	overall	overall	JJ
cord-003921-8r8z0otz	167	34	survival	survival	NN
cord-003921-8r8z0otz	167	35	as	as	IN
cord-003921-8r8z0otz	167	36	compared	compare	VBN
cord-003921-8r8z0otz	167	37	to	to	IN
cord-003921-8r8z0otz	167	38	WT	WT	NNP
cord-003921-8r8z0otz	167	39	counterparts	counterpart	NNS
cord-003921-8r8z0otz	167	40	.	.	.
cord-003921-8r8z0otz	168	1	The	the	DT
cord-003921-8r8z0otz	168	2	heterozygous	heterozygous	JJ
cord-003921-8r8z0otz	168	3	PAD4	PAD4	NNP
cord-003921-8r8z0otz	168	4	knockout	knockout	NN
cord-003921-8r8z0otz	168	5	mice	mouse	NNS
cord-003921-8r8z0otz	168	6	unexpectedly	unexpectedly	RB
cord-003921-8r8z0otz	168	7	showed	show	VBD
cord-003921-8r8z0otz	168	8	improved	improved	JJ
cord-003921-8r8z0otz	168	9	survival	survival	NN
cord-003921-8r8z0otz	168	10	as	as	IN
cord-003921-8r8z0otz	168	11	compared	compare	VBN
cord-003921-8r8z0otz	168	12	with	with	IN
cord-003921-8r8z0otz	168	13	WT	WT	NNP
cord-003921-8r8z0otz	168	14	counterparts	counterpart	NNS
cord-003921-8r8z0otz	168	15	or	or	CC
cord-003921-8r8z0otz	168	16	homozygous	homozygous	JJ
cord-003921-8r8z0otz	168	17	knockout	knockout	NN
cord-003921-8r8z0otz	168	18	mice	mouse	NNS
cord-003921-8r8z0otz	168	19	[	[	-LRB-
cord-003921-8r8z0otz	168	20	95•	95•	CD
cord-003921-8r8z0otz	168	21	]	]	-RRB-
cord-003921-8r8z0otz	168	22	;	;	:
cord-003921-8r8z0otz	168	23	in	in	IN
cord-003921-8r8z0otz	168	24	a	a	DT
cord-003921-8r8z0otz	168	25	mouse	mouse	NN
cord-003921-8r8z0otz	168	26	model	model	NN
cord-003921-8r8z0otz	168	27	of	of	IN
cord-003921-8r8z0otz	168	28	peritonitis	peritonitis	NN
cord-003921-8r8z0otz	168	29	,	,	,
cord-003921-8r8z0otz	168	30	degradation	degradation	NN
cord-003921-8r8z0otz	168	31	of	of	IN
cord-003921-8r8z0otz	168	32	NETs	net	NNS
cord-003921-8r8z0otz	168	33	by	by	IN
cord-003921-8r8z0otz	168	34	DNase	DNase	NNP
cord-003921-8r8z0otz	168	35	attenuated	attenuated	JJ
cord-003921-8r8z0otz	168	36	organ	organ	NN
cord-003921-8r8z0otz	168	37	damage	damage	NN
cord-003921-8r8z0otz	168	38	only	only	RB
cord-003921-8r8z0otz	168	39	when	when	WRB
cord-003921-8r8z0otz	168	40	combined	combine	VBN
cord-003921-8r8z0otz	168	41	with	with	IN
cord-003921-8r8z0otz	168	42	antibiotics	antibiotic	NNS
cord-003921-8r8z0otz	168	43	[	[	-LRB-
cord-003921-8r8z0otz	168	44	96	96	CD
cord-003921-8r8z0otz	168	45	]	]	-RRB-
cord-003921-8r8z0otz	168	46	;	;	:
cord-003921-8r8z0otz	169	1	in	in	IN
cord-003921-8r8z0otz	169	2	an	an	DT
cord-003921-8r8z0otz	169	3	experimental	experimental	JJ
cord-003921-8r8z0otz	169	4	model	model	NN
cord-003921-8r8z0otz	169	5	of	of	IN
cord-003921-8r8z0otz	169	6	a	a	DT
cord-003921-8r8z0otz	169	7	gout	gout	NN
cord-003921-8r8z0otz	169	8	(	(	-LRB-
cord-003921-8r8z0otz	169	9	acute	acute	JJ
cord-003921-8r8z0otz	169	10	sterile	sterile	JJ
cord-003921-8r8z0otz	169	11	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	169	12	reaction	reaction	NN
cord-003921-8r8z0otz	169	13	to	to	IN
cord-003921-8r8z0otz	169	14	monosodium	monosodium	NN
cord-003921-8r8z0otz	169	15	urate	urate	NN
cord-003921-8r8z0otz	169	16	crystals	crystal	NNS
cord-003921-8r8z0otz	169	17	)	)	-RRB-
cord-003921-8r8z0otz	169	18	,	,	,
cord-003921-8r8z0otz	169	19	NETosis	netosis	NN
cord-003921-8r8z0otz	169	20	-	-	HYPH
cord-003921-8r8z0otz	169	21	deficient	deficient	JJ
cord-003921-8r8z0otz	169	22	mice	mouse	NNS
cord-003921-8r8z0otz	169	23	developed	develop	VBD
cord-003921-8r8z0otz	169	24	exacerbated	exacerbate	VBN
cord-003921-8r8z0otz	169	25	and	and	CC
cord-003921-8r8z0otz	169	26	chronic	chronic	JJ
cord-003921-8r8z0otz	169	27	disease	disease	NN
cord-003921-8r8z0otz	169	28	that	that	WDT
cord-003921-8r8z0otz	169	29	could	could	MD
cord-003921-8r8z0otz	169	30	be	be	VB
cord-003921-8r8z0otz	169	31	reduced	reduce	VBN
cord-003921-8r8z0otz	169	32	by	by	IN
cord-003921-8r8z0otz	169	33	adoptive	adoptive	JJ
cord-003921-8r8z0otz	169	34	transfer	transfer	NN
cord-003921-8r8z0otz	169	35	of	of	IN
cord-003921-8r8z0otz	169	36	aggregated	aggregated	JJ
cord-003921-8r8z0otz	169	37	NETs	net	NNS
cord-003921-8r8z0otz	169	38	[	[	-LRB-
cord-003921-8r8z0otz	169	39	97	97	CD
cord-003921-8r8z0otz	169	40	]	]	-RRB-
cord-003921-8r8z0otz	169	41	.	.	.
cord-003921-8r8z0otz	170	1	Therefore	therefore	RB
cord-003921-8r8z0otz	170	2	,	,	,
cord-003921-8r8z0otz	170	3	the	the	DT
cord-003921-8r8z0otz	170	4	influence	influence	NN
cord-003921-8r8z0otz	170	5	of	of	IN
cord-003921-8r8z0otz	170	6	NETs	net	NNS
cord-003921-8r8z0otz	170	7	inhibition	inhibition	NN
cord-003921-8r8z0otz	170	8	depends	depend	VBZ
cord-003921-8r8z0otz	170	9	on	on	IN
cord-003921-8r8z0otz	170	10	disease	disease	NN
cord-003921-8r8z0otz	170	11	etiology	etiology	NN
cord-003921-8r8z0otz	170	12	and	and	CC
cord-003921-8r8z0otz	170	13	severity	severity	NN
cord-003921-8r8z0otz	170	14	of	of	IN
cord-003921-8r8z0otz	170	15	the	the	DT
cord-003921-8r8z0otz	170	16	inflammation	inflammation	NN
cord-003921-8r8z0otz	170	17	response	response	NN
cord-003921-8r8z0otz	170	18	.	.	.
cord-003921-8r8z0otz	171	1	Because	because	IN
cord-003921-8r8z0otz	171	2	of	of	IN
cord-003921-8r8z0otz	171	3	increased	increase	VBN
cord-003921-8r8z0otz	171	4	incidence	incidence	NN
cord-003921-8r8z0otz	171	5	of	of	IN
cord-003921-8r8z0otz	171	6	acute	acute	JJ
cord-003921-8r8z0otz	171	7	respiratory	respiratory	JJ
cord-003921-8r8z0otz	171	8	distress	distress	NN
cord-003921-8r8z0otz	171	9	syndrome	syndrome	NN
cord-003921-8r8z0otz	171	10	(	(	-LRB-
cord-003921-8r8z0otz	171	11	ARDS	ARDS	NNP
cord-003921-8r8z0otz	171	12	)	)	-RRB-
cord-003921-8r8z0otz	171	13	and	and	CC
cord-003921-8r8z0otz	171	14	acute	acute	JJ
cord-003921-8r8z0otz	171	15	kidney	kidney	NN
cord-003921-8r8z0otz	171	16	injury	injury	NN
cord-003921-8r8z0otz	171	17	in	in	IN
cord-003921-8r8z0otz	171	18	LT	LT	NNP
cord-003921-8r8z0otz	171	19	patients	patient	NNS
cord-003921-8r8z0otz	171	20	[	[	-LRB-
cord-003921-8r8z0otz	171	21	98	98	CD
cord-003921-8r8z0otz	171	22	,	,	,
cord-003921-8r8z0otz	171	23	99	99	CD
cord-003921-8r8z0otz	171	24	]	]	-RRB-
cord-003921-8r8z0otz	171	25	,	,	,
cord-003921-8r8z0otz	171	26	it	-PRON-	PRP
cord-003921-8r8z0otz	171	27	is	be	VBZ
cord-003921-8r8z0otz	171	28	important	important	JJ
cord-003921-8r8z0otz	171	29	to	to	TO
cord-003921-8r8z0otz	171	30	evaluate	evaluate	VB
cord-003921-8r8z0otz	171	31	potential	potential	JJ
cord-003921-8r8z0otz	171	32	clinical	clinical	JJ
cord-003921-8r8z0otz	171	33	value	value	NN
cord-003921-8r8z0otz	171	34	of	of	IN
cord-003921-8r8z0otz	171	35	NETs	net	NNS
cord-003921-8r8z0otz	171	36	reducing	reduce	VBG
cord-003921-8r8z0otz	171	37	therapeutic	therapeutic	JJ
cord-003921-8r8z0otz	171	38	strategies	strategy	NNS
cord-003921-8r8z0otz	171	39	.	.	.
cord-003921-8r8z0otz	172	1	It	-PRON-	PRP
cord-003921-8r8z0otz	172	2	has	have	VBZ
cord-003921-8r8z0otz	172	3	long	long	RB
cord-003921-8r8z0otz	172	4	been	be	VBN
cord-003921-8r8z0otz	172	5	accepted	accept	VBN
cord-003921-8r8z0otz	172	6	that	that	IN
cord-003921-8r8z0otz	172	7	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	172	8	is	be	VBZ
cord-003921-8r8z0otz	172	9	the	the	DT
cord-003921-8r8z0otz	172	10	most	most	RBS
cord-003921-8r8z0otz	172	11	common	common	JJ
cord-003921-8r8z0otz	172	12	and	and	CC
cord-003921-8r8z0otz	172	13	preferred	preferred	JJ
cord-003921-8r8z0otz	172	14	cell	cell	NN
cord-003921-8r8z0otz	172	15	death	death	NN
cord-003921-8r8z0otz	172	16	program	program	NN
cord-003921-8r8z0otz	172	17	to	to	TO
cord-003921-8r8z0otz	172	18	terminate	terminate	VB
cord-003921-8r8z0otz	172	19	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	172	20	activity	activity	NN
cord-003921-8r8z0otz	172	21	.	.	.
cord-003921-8r8z0otz	173	1	However	however	RB
cord-003921-8r8z0otz	173	2	,	,	,
cord-003921-8r8z0otz	173	3	recent	recent	JJ
cord-003921-8r8z0otz	173	4	evidence	evidence	NN
cord-003921-8r8z0otz	173	5	suggests	suggest	VBZ
cord-003921-8r8z0otz	173	6	that	that	IN
cord-003921-8r8z0otz	173	7	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	173	8	do	do	VBP
cord-003921-8r8z0otz	173	9	not	not	RB
cord-003921-8r8z0otz	173	10	necessarily	necessarily	RB
cord-003921-8r8z0otz	173	11	die	die	VB
cord-003921-8r8z0otz	173	12	in	in	IN
cord-003921-8r8z0otz	173	13	an	an	DT
cord-003921-8r8z0otz	173	14	inflamed	inflamed	JJ
cord-003921-8r8z0otz	173	15	site	site	NN
cord-003921-8r8z0otz	173	16	,	,	,
cord-003921-8r8z0otz	173	17	and	and	CC
cord-003921-8r8z0otz	173	18	instead	instead	RB
cord-003921-8r8z0otz	173	19	can	can	MD
cord-003921-8r8z0otz	173	20	leave	leave	VB
cord-003921-8r8z0otz	173	21	the	the	DT
cord-003921-8r8z0otz	173	22	site	site	NN
cord-003921-8r8z0otz	173	23	of	of	IN
cord-003921-8r8z0otz	173	24	tissue	tissue	NN
cord-003921-8r8z0otz	173	25	damage	damage	NN
cord-003921-8r8z0otz	173	26	in	in	IN
cord-003921-8r8z0otz	173	27	a	a	DT
cord-003921-8r8z0otz	173	28	process	process	NN
cord-003921-8r8z0otz	173	29	termed	term	VBN
cord-003921-8r8z0otz	173	30	as	as	IN
cord-003921-8r8z0otz	173	31	a	a	DT
cord-003921-8r8z0otz	173	32	"	"	``
cord-003921-8r8z0otz	173	33	reverse	reverse	JJ
cord-003921-8r8z0otz	173	34	migration	migration	NN
cord-003921-8r8z0otz	173	35	.	.	.
cord-003921-8r8z0otz	173	36	"	"	''
cord-003921-8r8z0otz	174	1	This	this	DT
cord-003921-8r8z0otz	174	2	phenomenon	phenomenon	NN
cord-003921-8r8z0otz	174	3	was	be	VBD
cord-003921-8r8z0otz	174	4	first	first	RB
cord-003921-8r8z0otz	174	5	visualized	visualize	VBN
cord-003921-8r8z0otz	174	6	in	in	IN
cord-003921-8r8z0otz	174	7	zebrafish	zebrafish	NN
cord-003921-8r8z0otz	174	8	larvae	larva	NNS
cord-003921-8r8z0otz	174	9	in	in	IN
cord-003921-8r8z0otz	174	10	which	which	WDT
cord-003921-8r8z0otz	174	11	most	most	JJS
cord-003921-8r8z0otz	174	12	of	of	IN
cord-003921-8r8z0otz	174	13	the	the	DT
cord-003921-8r8z0otz	174	14	recruited	recruit	VBN
cord-003921-8r8z0otz	174	15	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	174	16	leave	leave	VBP
cord-003921-8r8z0otz	174	17	a	a	DT
cord-003921-8r8z0otz	174	18	damaged	damage	VBN
cord-003921-8r8z0otz	174	19	site	site	NN
cord-003921-8r8z0otz	174	20	and	and	CC
cord-003921-8r8z0otz	174	21	traffic	traffic	NN
cord-003921-8r8z0otz	174	22	to	to	IN
cord-003921-8r8z0otz	174	23	a	a	DT
cord-003921-8r8z0otz	174	24	distal	distal	JJ
cord-003921-8r8z0otz	174	25	site	site	NN
cord-003921-8r8z0otz	174	26	[	[	-LRB-
cord-003921-8r8z0otz	174	27	100	100	CD
cord-003921-8r8z0otz	174	28	,	,	,
cord-003921-8r8z0otz	174	29	101	101	CD
cord-003921-8r8z0otz	174	30	]	]	-RRB-
cord-003921-8r8z0otz	174	31	.	.	.
cord-003921-8r8z0otz	175	1	A	a	DT
cord-003921-8r8z0otz	175	2	recent	recent	JJ
cord-003921-8r8z0otz	175	3	study	study	NN
cord-003921-8r8z0otz	175	4	combining	combine	VBG
cord-003921-8r8z0otz	175	5	intravital	intravital	JJ
cord-003921-8r8z0otz	175	6	imaging	imaging	NN
cord-003921-8r8z0otz	175	7	and	and	CC
cord-003921-8r8z0otz	175	8	photoactivation	photoactivation	NN
cord-003921-8r8z0otz	175	9	techniques	technique	NNS
cord-003921-8r8z0otz	175	10	in	in	IN
cord-003921-8r8z0otz	175	11	a	a	DT
cord-003921-8r8z0otz	175	12	mouse	mouse	NN
cord-003921-8r8z0otz	175	13	thermal	thermal	JJ
cord-003921-8r8z0otz	175	14	hepatic	hepatic	JJ
cord-003921-8r8z0otz	175	15	injury	injury	NN
cord-003921-8r8z0otz	175	16	model	model	NN
cord-003921-8r8z0otz	175	17	demonstrated	demonstrate	VBD
cord-003921-8r8z0otz	175	18	that	that	IN
cord-003921-8r8z0otz	175	19	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	175	20	recruited	recruit	VBN
cord-003921-8r8z0otz	175	21	to	to	IN
cord-003921-8r8z0otz	175	22	the	the	DT
cord-003921-8r8z0otz	175	23	stressed	stressed	JJ
cord-003921-8r8z0otz	175	24	tissue	tissue	NN
cord-003921-8r8z0otz	175	25	neither	neither	CC
cord-003921-8r8z0otz	175	26	underwent	undergo	VBD
cord-003921-8r8z0otz	175	27	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	175	28	,	,	,
cord-003921-8r8z0otz	175	29	necrosis	necrosis	NN
cord-003921-8r8z0otz	175	30	,	,	,
cord-003921-8r8z0otz	175	31	nor	nor	CC
cord-003921-8r8z0otz	175	32	phagocytosis	phagocytosis	NN
cord-003921-8r8z0otz	175	33	by	by	IN
cord-003921-8r8z0otz	175	34	monocytes	monocyte	NNS
cord-003921-8r8z0otz	175	35	,	,	,
cord-003921-8r8z0otz	175	36	but	but	CC
cord-003921-8r8z0otz	175	37	instead	instead	RB
cord-003921-8r8z0otz	175	38	reversely	reversely	RB
cord-003921-8r8z0otz	175	39	migrated	migrate	VBN
cord-003921-8r8z0otz	175	40	to	to	IN
cord-003921-8r8z0otz	175	41	the	the	DT
cord-003921-8r8z0otz	175	42	circulation	circulation	NN
cord-003921-8r8z0otz	175	43	,	,	,
cord-003921-8r8z0otz	175	44	became	become	VBD
cord-003921-8r8z0otz	175	45	arrested	arrest	VBN
cord-003921-8r8z0otz	175	46	within	within	IN
cord-003921-8r8z0otz	175	47	the	the	DT
cord-003921-8r8z0otz	175	48	lung	lung	NN
cord-003921-8r8z0otz	175	49	without	without	IN
cord-003921-8r8z0otz	175	50	causing	cause	VBG
cord-003921-8r8z0otz	175	51	local	local	JJ
cord-003921-8r8z0otz	175	52	tissue	tissue	NN
cord-003921-8r8z0otz	175	53	injury	injury	NN
cord-003921-8r8z0otz	175	54	,	,	,
cord-003921-8r8z0otz	175	55	and	and	CC
cord-003921-8r8z0otz	175	56	then	then	RB
cord-003921-8r8z0otz	175	57	homed	home	VBD
cord-003921-8r8z0otz	175	58	to	to	IN
cord-003921-8r8z0otz	175	59	the	the	DT
cord-003921-8r8z0otz	175	60	bone	bone	NN
cord-003921-8r8z0otz	175	61	marrow	marrow	NN
cord-003921-8r8z0otz	175	62	where	where	WRB
cord-003921-8r8z0otz	175	63	they	-PRON-	PRP
cord-003921-8r8z0otz	175	64	ultimately	ultimately	RB
cord-003921-8r8z0otz	175	65	underwent	undergo	VBD
cord-003921-8r8z0otz	175	66	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	175	67	[	[	-LRB-
cord-003921-8r8z0otz	175	68	83•	83•	NNP
cord-003921-8r8z0otz	175	69	]	]	-RRB-
cord-003921-8r8z0otz	175	70	.	.	.
cord-003921-8r8z0otz	176	1	In	in	IN
cord-003921-8r8z0otz	176	2	contrast	contrast	NN
cord-003921-8r8z0otz	176	3	,	,	,
cord-003921-8r8z0otz	176	4	in	in	IN
cord-003921-8r8z0otz	176	5	hepatic	hepatic	JJ
cord-003921-8r8z0otz	176	6	IRI	IRI	NNP
cord-003921-8r8z0otz	176	7	or	or	CC
cord-003921-8r8z0otz	176	8	acute	acute	JJ
cord-003921-8r8z0otz	176	9	pancreatitis	pancreatitis	NN
cord-003921-8r8z0otz	176	10	model	model	NN
cord-003921-8r8z0otz	176	11	,	,	,
cord-003921-8r8z0otz	176	12	activated	activate	VBN
cord-003921-8r8z0otz	176	13	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	176	14	were	be	VBD
cord-003921-8r8z0otz	176	15	redistributed	redistribute	VBN
cord-003921-8r8z0otz	176	16	to	to	TO
cord-003921-8r8z0otz	176	17	produce	produce	VB
cord-003921-8r8z0otz	176	18	remote	remote	JJ
cord-003921-8r8z0otz	176	19	organ	organ	NN
cord-003921-8r8z0otz	176	20	injury	injury	NN
cord-003921-8r8z0otz	176	21	[	[	-LRB-
cord-003921-8r8z0otz	176	22	102	102	CD
cord-003921-8r8z0otz	176	23	]	]	-RRB-
cord-003921-8r8z0otz	176	24	[	[	-LRB-
cord-003921-8r8z0otz	176	25	103	103	CD
cord-003921-8r8z0otz	176	26	]	]	-RRB-
cord-003921-8r8z0otz	176	27	[	[	-LRB-
cord-003921-8r8z0otz	176	28	104	104	CD
cord-003921-8r8z0otz	176	29	]	]	-RRB-
cord-003921-8r8z0otz	176	30	.	.	.
cord-003921-8r8z0otz	177	1	It	-PRON-	PRP
cord-003921-8r8z0otz	177	2	is	be	VBZ
cord-003921-8r8z0otz	177	3	noteworthy	noteworthy	JJ
cord-003921-8r8z0otz	177	4	that	that	IN
cord-003921-8r8z0otz	177	5	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	177	6	undergoing	undergo	VBG
cord-003921-8r8z0otz	177	7	transendothelial	transendothelial	JJ
cord-003921-8r8z0otz	177	8	migration	migration	NN
cord-003921-8r8z0otz	177	9	in	in	IN
cord-003921-8r8z0otz	177	10	vitro	vitro	FW
cord-003921-8r8z0otz	177	11	expressed	express	VBD
cord-003921-8r8z0otz	177	12	specific	specific	JJ
cord-003921-8r8z0otz	177	13	marker	marker	NN
cord-003921-8r8z0otz	177	14	,	,	,
cord-003921-8r8z0otz	178	1	ICAM1	ICAM1	NNP
cord-003921-8r8z0otz	178	2	high	high	NNP
cord-003921-8r8z0otz	178	3	/	/	SYM
cord-003921-8r8z0otz	178	4	CXCR1	cxcr1	NN
cord-003921-8r8z0otz	178	5	low	low	NN
cord-003921-8r8z0otz	178	6	,	,	,
cord-003921-8r8z0otz	178	7	which	which	WDT
cord-003921-8r8z0otz	178	8	was	be	VBD
cord-003921-8r8z0otz	178	9	resistant	resistant	JJ
cord-003921-8r8z0otz	178	10	to	to	IN
cord-003921-8r8z0otz	178	11	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	178	12	and	and	CC
cord-003921-8r8z0otz	178	13	produced	produce	VBD
cord-003921-8r8z0otz	178	14	more	more	JJR
cord-003921-8r8z0otz	178	15	ROS	ROS	NNP
cord-003921-8r8z0otz	178	16	[	[	-LRB-
cord-003921-8r8z0otz	178	17	102	102	CD
cord-003921-8r8z0otz	178	18	]	]	-RRB-
cord-003921-8r8z0otz	178	19	,	,	.
cord-003921-8r8z0otz	179	1	whereas	whereas	IN
cord-003921-8r8z0otz	179	2	patients	patient	NNS
cord-003921-8r8z0otz	179	3	with	with	IN
cord-003921-8r8z0otz	179	4	acute	acute	JJ
cord-003921-8r8z0otz	179	5	pancreatitis	pancreatitis	NN
cord-003921-8r8z0otz	179	6	who	who	WP
cord-003921-8r8z0otz	179	7	developed	develop	VBD
cord-003921-8r8z0otz	179	8	acute	acute	JJ
cord-003921-8r8z0otz	179	9	lung	lung	NN
cord-003921-8r8z0otz	179	10	injury	injury	NN
cord-003921-8r8z0otz	179	11	had	have	VBD
cord-003921-8r8z0otz	179	12	more	more	JJR
cord-003921-8r8z0otz	179	13	ICAM1	ICAM1	NNP
cord-003921-8r8z0otz	179	14	high	high	JJ
cord-003921-8r8z0otz	179	15	/	/	SYM
cord-003921-8r8z0otz	179	16	CXCR1	cxcr1	NN
cord-003921-8r8z0otz	179	17	low	low	JJ
cord-003921-8r8z0otz	179	18	expressing	express	VBG
cord-003921-8r8z0otz	179	19	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	179	20	in	in	IN
cord-003921-8r8z0otz	179	21	their	-PRON-	PRP$
cord-003921-8r8z0otz	179	22	circulation	circulation	NN
cord-003921-8r8z0otz	179	23	[	[	-LRB-
cord-003921-8r8z0otz	179	24	104	104	CD
cord-003921-8r8z0otz	179	25	]	]	-RRB-
cord-003921-8r8z0otz	179	26	.	.	.
cord-003921-8r8z0otz	180	1	This	this	DT
cord-003921-8r8z0otz	180	2	implies	imply	VBZ
cord-003921-8r8z0otz	180	3	the	the	DT
cord-003921-8r8z0otz	180	4	potential	potential	NN
cord-003921-8r8z0otz	180	5	for	for	IN
cord-003921-8r8z0otz	180	6	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	180	7	reprograming	reprograming	NN
cord-003921-8r8z0otz	180	8	or	or	CC
cord-003921-8r8z0otz	180	9	existence	existence	NN
cord-003921-8r8z0otz	180	10	of	of	IN
cord-003921-8r8z0otz	180	11	active	active	JJ
cord-003921-8r8z0otz	180	12	/	/	SYM
cord-003921-8r8z0otz	180	13	inactive	inactive	JJ
cord-003921-8r8z0otz	180	14	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	180	15	subsets	subset	NNS
cord-003921-8r8z0otz	180	16	after	after	IN
cord-003921-8r8z0otz	180	17	reverse	reverse	JJ
cord-003921-8r8z0otz	180	18	migration	migration	NN
cord-003921-8r8z0otz	180	19	.	.	.
cord-003921-8r8z0otz	181	1	However	however	RB
cord-003921-8r8z0otz	181	2	,	,	,
cord-003921-8r8z0otz	181	3	there	there	EX
cord-003921-8r8z0otz	181	4	is	be	VBZ
cord-003921-8r8z0otz	181	5	no	no	DT
cord-003921-8r8z0otz	181	6	rigorous	rigorous	JJ
cord-003921-8r8z0otz	181	7	evidence	evidence	NN
cord-003921-8r8z0otz	181	8	as	as	IN
cord-003921-8r8z0otz	181	9	to	to	IN
cord-003921-8r8z0otz	181	10	why	why	WRB
cord-003921-8r8z0otz	181	11	and	and	CC
cord-003921-8r8z0otz	181	12	how	how	WRB
cord-003921-8r8z0otz	181	13	reversely	reversely	RB
cord-003921-8r8z0otz	181	14	migrating	migrate	VBG
cord-003921-8r8z0otz	181	15	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	181	16	can	can	MD
cord-003921-8r8z0otz	181	17	be	be	VB
cord-003921-8r8z0otz	181	18	toxic	toxic	JJ
cord-003921-8r8z0otz	181	19	in	in	IN
cord-003921-8r8z0otz	181	20	some	some	DT
cord-003921-8r8z0otz	181	21	cases	case	NNS
cord-003921-8r8z0otz	181	22	but	but	CC
cord-003921-8r8z0otz	181	23	inactive	inactive	JJ
cord-003921-8r8z0otz	181	24	in	in	IN
cord-003921-8r8z0otz	181	25	other	other	JJ
cord-003921-8r8z0otz	181	26	pathology	pathology	NN
cord-003921-8r8z0otz	181	27	states	state	NNS
cord-003921-8r8z0otz	181	28	.	.	.
cord-003921-8r8z0otz	182	1	Neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	182	2	have	have	VBP
cord-003921-8r8z0otz	182	3	long	long	RB
cord-003921-8r8z0otz	182	4	been	be	VBN
cord-003921-8r8z0otz	182	5	recognized	recognize	VBN
cord-003921-8r8z0otz	182	6	as	as	IN
cord-003921-8r8z0otz	182	7	important	important	JJ
cord-003921-8r8z0otz	182	8	players	player	NNS
cord-003921-8r8z0otz	182	9	in	in	IN
cord-003921-8r8z0otz	182	10	liver	liver	NN
cord-003921-8r8z0otz	182	11	IRI	IRI	NNP
cord-003921-8r8z0otz	182	12	,	,	,
cord-003921-8r8z0otz	182	13	while	while	IN
cord-003921-8r8z0otz	182	14	great	great	JJ
cord-003921-8r8z0otz	182	15	majority	majority	NN
cord-003921-8r8z0otz	182	16	of	of	IN
cord-003921-8r8z0otz	182	17	studies	study	NNS
cord-003921-8r8z0otz	182	18	focused	focus	VBN
cord-003921-8r8z0otz	182	19	on	on	IN
cord-003921-8r8z0otz	182	20	their	-PRON-	PRP$
cord-003921-8r8z0otz	182	21	proinflammatory	proinflammatory	JJ
cord-003921-8r8z0otz	182	22	and	and	CC
cord-003921-8r8z0otz	182	23	tissue	tissue	NN
cord-003921-8r8z0otz	182	24	-	-	HYPH
cord-003921-8r8z0otz	182	25	destructive	destructive	JJ
cord-003921-8r8z0otz	182	26	functions	function	NNS
cord-003921-8r8z0otz	182	27	.	.	.
cord-003921-8r8z0otz	183	1	Indeed	indeed	RB
cord-003921-8r8z0otz	183	2	,	,	,
cord-003921-8r8z0otz	183	3	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	183	4	-	-	HYPH
cord-003921-8r8z0otz	183	5	targeting	target	VBG
cord-003921-8r8z0otz	183	6	strategies	strategy	NNS
cord-003921-8r8z0otz	183	7	mostly	mostly	RB
cord-003921-8r8z0otz	183	8	narrowed	narrow	VBD
cord-003921-8r8z0otz	183	9	at	at	IN
cord-003921-8r8z0otz	183	10	reducing	reduce	VBG
cord-003921-8r8z0otz	183	11	their	-PRON-	PRP$
cord-003921-8r8z0otz	183	12	target	target	NN
cord-003921-8r8z0otz	183	13	organ	organ	NN
cord-003921-8r8z0otz	183	14	infiltration	infiltration	NN
cord-003921-8r8z0otz	183	15	.	.	.
cord-003921-8r8z0otz	184	1	Table	table	NN
cord-003921-8r8z0otz	184	2	2	2	CD
cord-003921-8r8z0otz	184	3	lists	list	NNS
cord-003921-8r8z0otz	184	4	representative	representative	VBP
cord-003921-8r8z0otz	184	5	preclinical	preclinical	JJ
cord-003921-8r8z0otz	184	6	studies	study	NNS
cord-003921-8r8z0otz	184	7	on	on	IN
cord-003921-8r8z0otz	184	8	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	184	9	targeting	target	VBG
cord-003921-8r8z0otz	184	10	in	in	IN
cord-003921-8r8z0otz	184	11	liver	liver	NN
cord-003921-8r8z0otz	184	12	IRI	IRI	NNP
cord-003921-8r8z0otz	184	13	[	[	-LRB-
cord-003921-8r8z0otz	184	14	23	23	CD
cord-003921-8r8z0otz	184	15	,	,	,
cord-003921-8r8z0otz	184	16	24	24	CD
cord-003921-8r8z0otz	184	17	,	,	,
cord-003921-8r8z0otz	184	18	30	30	CD
cord-003921-8r8z0otz	184	19	,	,	,
cord-003921-8r8z0otz	184	20	34•	34•	CD
cord-003921-8r8z0otz	184	21	,	,	,
cord-003921-8r8z0otz	184	22	40	40	CD
cord-003921-8r8z0otz	184	23	,	,	,
cord-003921-8r8z0otz	184	24	45	45	CD
cord-003921-8r8z0otz	184	25	,	,	,
cord-003921-8r8z0otz	184	26	47	47	CD
cord-003921-8r8z0otz	184	27	,	,	,
cord-003921-8r8z0otz	184	28	56•	56•	CD
cord-003921-8r8z0otz	184	29	,	,	,
cord-003921-8r8z0otz	184	30	105	105	CD
cord-003921-8r8z0otz	184	31	-	-	SYM
cord-003921-8r8z0otz	184	32	107	107	CD
cord-003921-8r8z0otz	184	33	]	]	-RRB-
cord-003921-8r8z0otz	184	34	.	.	.
cord-003921-8r8z0otz	185	1	It	-PRON-	PRP
cord-003921-8r8z0otz	185	2	is	be	VBZ
cord-003921-8r8z0otz	185	3	important	important	JJ
cord-003921-8r8z0otz	185	4	to	to	TO
cord-003921-8r8z0otz	185	5	keep	keep	VB
cord-003921-8r8z0otz	185	6	in	in	IN
cord-003921-8r8z0otz	185	7	mind	mind	NN
cord-003921-8r8z0otz	185	8	that	that	IN
cord-003921-8r8z0otz	185	9	LT	LT	NNP
cord-003921-8r8z0otz	185	10	recipients	recipient	NNS
cord-003921-8r8z0otz	185	11	are	be	VBP
cord-003921-8r8z0otz	185	12	immunocompromised	immunocompromised	JJ
cord-003921-8r8z0otz	185	13	while	while	IN
cord-003921-8r8z0otz	185	14	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	185	15	constitute	constitute	VBP
cord-003921-8r8z0otz	185	16	the	the	DT
cord-003921-8r8z0otz	185	17	forefront	forefront	NN
cord-003921-8r8z0otz	185	18	of	of	IN
cord-003921-8r8z0otz	185	19	pathogen	pathogen	NN
cord-003921-8r8z0otz	185	20	host	host	NN
cord-003921-8r8z0otz	185	21	defense	defense	NN
cord-003921-8r8z0otz	185	22	.	.	.
cord-003921-8r8z0otz	186	1	Hence	hence	RB
cord-003921-8r8z0otz	186	2	,	,	,
cord-003921-8r8z0otz	186	3	therapies	therapy	NNS
cord-003921-8r8z0otz	186	4	limiting	limit	VBG
cord-003921-8r8z0otz	186	5	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	186	6	sequestration	sequestration	NN
cord-003921-8r8z0otz	186	7	and/or	and/or	CC
cord-003921-8r8z0otz	186	8	effector	effector	NN
cord-003921-8r8z0otz	186	9	functions	function	NNS
cord-003921-8r8z0otz	186	10	may	may	MD
cord-003921-8r8z0otz	186	11	in	in	IN
cord-003921-8r8z0otz	186	12	turn	turn	NN
cord-003921-8r8z0otz	186	13	increase	increase	VB
cord-003921-8r8z0otz	186	14	the	the	DT
cord-003921-8r8z0otz	186	15	risk	risk	NN
cord-003921-8r8z0otz	186	16	of	of	IN
cord-003921-8r8z0otz	186	17	infections	infection	NNS
cord-003921-8r8z0otz	186	18	in	in	IN
cord-003921-8r8z0otz	186	19	transplant	transplant	NN
cord-003921-8r8z0otz	186	20	recipients	recipient	NNS
cord-003921-8r8z0otz	186	21	.	.	.
cord-003921-8r8z0otz	187	1	Despite	despite	IN
cord-003921-8r8z0otz	187	2	preclinical	preclinical	JJ
cord-003921-8r8z0otz	187	3	studies	study	NNS
cord-003921-8r8z0otz	187	4	showing	show	VBG
cord-003921-8r8z0otz	187	5	therapeutic	therapeutic	JJ
cord-003921-8r8z0otz	187	6	efficacy	efficacy	NN
cord-003921-8r8z0otz	187	7	,	,	,
cord-003921-8r8z0otz	187	8	global	global	JJ
cord-003921-8r8z0otz	187	9	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	187	10	depletion	depletion	NN
cord-003921-8r8z0otz	187	11	is	be	VBZ
cord-003921-8r8z0otz	187	12	unlikely	unlikely	JJ
cord-003921-8r8z0otz	187	13	to	to	TO
cord-003921-8r8z0otz	187	14	be	be	VB
cord-003921-8r8z0otz	187	15	clinically	clinically	RB
cord-003921-8r8z0otz	187	16	feasible	feasible	JJ
cord-003921-8r8z0otz	187	17	.	.	.
cord-003921-8r8z0otz	188	1	More	more	RBR
cord-003921-8r8z0otz	188	2	specific	specific	JJ
cord-003921-8r8z0otz	188	3	maneuvers	maneuver	NNS
cord-003921-8r8z0otz	188	4	to	to	TO
cord-003921-8r8z0otz	188	5	inhibit	inhibit	VB
cord-003921-8r8z0otz	188	6	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	188	7	adhesion	adhesion	NN
cord-003921-8r8z0otz	188	8	,	,	,
cord-003921-8r8z0otz	188	9	migration	migration	NN
cord-003921-8r8z0otz	188	10	,	,	,
cord-003921-8r8z0otz	188	11	and	and	CC
cord-003921-8r8z0otz	188	12	effector	effector	NN
cord-003921-8r8z0otz	188	13	functions	function	NNS
cord-003921-8r8z0otz	188	14	are	be	VBP
cord-003921-8r8z0otz	188	15	required	require	VBN
cord-003921-8r8z0otz	188	16	,	,	,
cord-003921-8r8z0otz	188	17	though	though	IN
cord-003921-8r8z0otz	188	18	it	-PRON-	PRP
cord-003921-8r8z0otz	188	19	remains	remain	VBZ
cord-003921-8r8z0otz	188	20	to	to	TO
cord-003921-8r8z0otz	188	21	be	be	VB
cord-003921-8r8z0otz	188	22	determined	determine	VBN
cord-003921-8r8z0otz	188	23	whether	whether	IN
cord-003921-8r8z0otz	188	24	and	and	CC
cord-003921-8r8z0otz	188	25	how	how	WRB
cord-003921-8r8z0otz	188	26	such	such	JJ
cord-003921-8r8z0otz	188	27	therapies	therapy	NNS
cord-003921-8r8z0otz	188	28	can	can	MD
cord-003921-8r8z0otz	188	29	achieve	achieve	VB
cord-003921-8r8z0otz	188	30	optimal	optimal	JJ
cord-003921-8r8z0otz	188	31	balance	balance	NN
cord-003921-8r8z0otz	188	32	between	between	IN
cord-003921-8r8z0otz	188	33	effective	effective	JJ
cord-003921-8r8z0otz	188	34	host	host	NN
cord-003921-8r8z0otz	188	35	immune	immune	JJ
cord-003921-8r8z0otz	188	36	surveillance	surveillance	NN
cord-003921-8r8z0otz	188	37	while	while	IN
cord-003921-8r8z0otz	188	38	controlling	control	VBG
cord-003921-8r8z0otz	188	39	cytodestruction	cytodestruction	NN
cord-003921-8r8z0otz	188	40	.	.	.
cord-003921-8r8z0otz	189	1	Albeit	albeit	IN
cord-003921-8r8z0otz	189	2	non	non	JJ
cord-003921-8r8z0otz	189	3	-	-	JJ
cord-003921-8r8z0otz	189	4	specifically	specifically	RB
cord-003921-8r8z0otz	189	5	targeting	target	VBG
cord-003921-8r8z0otz	189	6	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	189	7	functions	function	NNS
cord-003921-8r8z0otz	189	8	,	,	,
cord-003921-8r8z0otz	189	9	the	the	DT
cord-003921-8r8z0otz	189	10	reduction	reduction	NN
cord-003921-8r8z0otz	189	11	of	of	IN
cord-003921-8r8z0otz	189	12	extracellular	extracellular	JJ
cord-003921-8r8z0otz	189	13	DAMPs	damp	NNS
cord-003921-8r8z0otz	189	14	such	such	JJ
cord-003921-8r8z0otz	189	15	as	as	IN
cord-003921-8r8z0otz	189	16	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	190	1	or	or	CC
cord-003921-8r8z0otz	190	2	histone	histone	NN
cord-003921-8r8z0otz	190	3	seems	seem	VBZ
cord-003921-8r8z0otz	190	4	favorable	favorable	JJ
cord-003921-8r8z0otz	190	5	,	,	,
cord-003921-8r8z0otz	190	6	because	because	IN
cord-003921-8r8z0otz	190	7	DAMPs	damp	NNS
cord-003921-8r8z0otz	190	8	are	be	VBP
cord-003921-8r8z0otz	190	9	the	the	DT
cord-003921-8r8z0otz	190	10	immune	immune	NN
cord-003921-8r8z0otz	190	11	-	-	HYPH
cord-003921-8r8z0otz	190	12	activating	activate	VBG
cord-003921-8r8z0otz	190	13	signals	signal	NNS
cord-003921-8r8z0otz	190	14	released	release	VBN
cord-003921-8r8z0otz	190	15	from	from	IN
cord-003921-8r8z0otz	190	16	host	host	NN
cord-003921-8r8z0otz	190	17	cells	cell	NNS
cord-003921-8r8z0otz	190	18	but	but	CC
cord-003921-8r8z0otz	190	19	not	not	RB
cord-003921-8r8z0otz	190	20	from	from	IN
cord-003921-8r8z0otz	190	21	pathogens	pathogen	NNS
cord-003921-8r8z0otz	190	22	.	.	.
cord-003921-8r8z0otz	191	1	Of	of	IN
cord-003921-8r8z0otz	191	2	note	note	NN
cord-003921-8r8z0otz	191	3	,	,	,
cord-003921-8r8z0otz	191	4	one	one	CD
cord-003921-8r8z0otz	191	5	of	of	IN
cord-003921-8r8z0otz	191	6	the	the	DT
cord-003921-8r8z0otz	191	7	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	191	8	inactivators	inactivators	NNP
cord-003921-8r8z0otz	191	9	(	(	-LRB-
cord-003921-8r8z0otz	191	10	ART-123	ART-123	NNP
cord-003921-8r8z0otz	191	11	,	,	,
cord-003921-8r8z0otz	191	12	recombinant	recombinant	JJ
cord-003921-8r8z0otz	191	13	thrombomodulin	thrombomodulin	NNP
cord-003921-8r8z0otz	191	14	)	)	-RRB-
cord-003921-8r8z0otz	191	15	,	,	,
cord-003921-8r8z0otz	191	16	originally	originally	RB
cord-003921-8r8z0otz	191	17	shown	show	VBN
cord-003921-8r8z0otz	191	18	to	to	TO
cord-003921-8r8z0otz	191	19	mitigate	mitigate	VB
cord-003921-8r8z0otz	191	20	liver	liver	NN
cord-003921-8r8z0otz	191	21	IRI	IRI	NNP
cord-003921-8r8z0otz	191	22	in	in	IN
cord-003921-8r8z0otz	191	23	TLR4	TLR4	NNP
cord-003921-8r8z0otz	191	24	depending	depend	VBG
cord-003921-8r8z0otz	191	25	manner	manner	NN
cord-003921-8r8z0otz	191	26	[	[	-LRB-
cord-003921-8r8z0otz	191	27	27•	27•	CD
cord-003921-8r8z0otz	191	28	]	]	-RRB-
cord-003921-8r8z0otz	191	29	,	,	,
cord-003921-8r8z0otz	191	30	is	be	VBZ
cord-003921-8r8z0otz	191	31	now	now	RB
cord-003921-8r8z0otz	191	32	used	use	VBN
cord-003921-8r8z0otz	191	33	clinically	clinically	RB
cord-003921-8r8z0otz	191	34	for	for	IN
cord-003921-8r8z0otz	191	35	disseminated	disseminate	VBN
cord-003921-8r8z0otz	191	36	intravascular	intravascular	JJ
cord-003921-8r8z0otz	191	37	coagulation	coagulation	NN
cord-003921-8r8z0otz	191	38	[	[	-LRB-
cord-003921-8r8z0otz	191	39	108	108	CD
cord-003921-8r8z0otz	191	40	,	,	,
cord-003921-8r8z0otz	191	41	109	109	CD
cord-003921-8r8z0otz	191	42	]	]	-RRB-
cord-003921-8r8z0otz	191	43	.	.	.
cord-003921-8r8z0otz	192	1	In	in	IN
cord-003921-8r8z0otz	192	2	agreement	agreement	NN
cord-003921-8r8z0otz	192	3	with	with	IN
cord-003921-8r8z0otz	192	4	recent	recent	JJ
cord-003921-8r8z0otz	192	5	data	datum	NNS
cord-003921-8r8z0otz	192	6	[	[	-LRB-
cord-003921-8r8z0otz	192	7	54•	54•	CD
cord-003921-8r8z0otz	192	8	,	,	,
cord-003921-8r8z0otz	192	9	56•	56•	CD
cord-003921-8r8z0otz	192	10	]	]	-RRB-
cord-003921-8r8z0otz	192	11	,	,	,
cord-003921-8r8z0otz	192	12	inhibition	inhibition	NN
cord-003921-8r8z0otz	192	13	of	of	IN
cord-003921-8r8z0otz	192	14	NETs	net	NNS
cord-003921-8r8z0otz	192	15	formation	formation	NN
cord-003921-8r8z0otz	192	16	by	by	IN
cord-003921-8r8z0otz	192	17	specifically	specifically	RB
cord-003921-8r8z0otz	192	18	targeting	target	VBG
cord-003921-8r8z0otz	192	19	highly	highly	RB
cord-003921-8r8z0otz	192	20	destructive	destructive	JJ
cord-003921-8r8z0otz	192	21	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	192	22	function	function	NN
cord-003921-8r8z0otz	192	23	seems	seem	VBZ
cord-003921-8r8z0otz	192	24	biologically	biologically	RB
cord-003921-8r8z0otz	192	25	beneficial	beneficial	JJ
cord-003921-8r8z0otz	192	26	.	.	.
cord-003921-8r8z0otz	193	1	However	however	RB
cord-003921-8r8z0otz	193	2	,	,	,
cord-003921-8r8z0otz	193	3	futures	future	NNS
cord-003921-8r8z0otz	193	4	studies	study	NNS
cord-003921-8r8z0otz	193	5	need	need	VBP
cord-003921-8r8z0otz	193	6	to	to	TO
cord-003921-8r8z0otz	193	7	evaluate	evaluate	VB
cord-003921-8r8z0otz	193	8	potential	potential	JJ
cord-003921-8r8z0otz	193	9	risks	risk	NNS
cord-003921-8r8z0otz	193	10	,	,	,
cord-003921-8r8z0otz	193	11	as	as	IN
cord-003921-8r8z0otz	193	12	this	this	DT
cord-003921-8r8z0otz	193	13	maneuver	maneuver	NN
cord-003921-8r8z0otz	193	14	may	may	MD
cord-003921-8r8z0otz	193	15	spread	spread	VB
cord-003921-8r8z0otz	193	16	abundant	abundant	JJ
cord-003921-8r8z0otz	193	17	DAMPs	damp	NNS
cord-003921-8r8z0otz	193	18	or	or	CC
cord-003921-8r8z0otz	193	19	pathogens	pathogen	NNS
cord-003921-8r8z0otz	193	20	,	,	,
cord-003921-8r8z0otz	193	21	which	which	WDT
cord-003921-8r8z0otz	193	22	otherwise	otherwise	RB
cord-003921-8r8z0otz	193	23	should	should	MD
cord-003921-8r8z0otz	193	24	be	be	VB
cord-003921-8r8z0otz	193	25	isolated	isolate	VBN
cord-003921-8r8z0otz	193	26	inside	inside	IN
cord-003921-8r8z0otz	193	27	the	the	DT
cord-003921-8r8z0otz	193	28	NETs	net	NNS
cord-003921-8r8z0otz	193	29	areas	area	NNS
cord-003921-8r8z0otz	193	30	.	.	.
cord-003921-8r8z0otz	194	1	Since	since	IN
cord-003921-8r8z0otz	194	2	DNase	DNase	NNP
cord-003921-8r8z0otz	194	3	has	have	VBZ
cord-003921-8r8z0otz	194	4	been	be	VBN
cord-003921-8r8z0otz	194	5	successfully	successfully	RB
cord-003921-8r8z0otz	194	6	applied	apply	VBN
cord-003921-8r8z0otz	194	7	for	for	IN
cord-003921-8r8z0otz	194	8	the	the	DT
cord-003921-8r8z0otz	194	9	treatment	treatment	NN
cord-003921-8r8z0otz	194	10	of	of	IN
cord-003921-8r8z0otz	194	11	cystic	cystic	JJ
cord-003921-8r8z0otz	194	12	fibrosis	fibrosis	NN
cord-003921-8r8z0otz	194	13	patients	patient	NNS
cord-003921-8r8z0otz	194	14	and	and	CC
cord-003921-8r8z0otz	194	15	the	the	DT
cord-003921-8r8z0otz	194	16	NETs	net	NNS
cord-003921-8r8z0otz	194	17	digestion	digestion	NN
cord-003921-8r8z0otz	194	18	is	be	VBZ
cord-003921-8r8z0otz	194	19	considered	consider	VBN
cord-003921-8r8z0otz	194	20	to	to	TO
cord-003921-8r8z0otz	194	21	be	be	VB
cord-003921-8r8z0otz	194	22	a	a	DT
cord-003921-8r8z0otz	194	23	part	part	NN
cord-003921-8r8z0otz	194	24	of	of	IN
cord-003921-8r8z0otz	194	25	its	-PRON-	PRP$
cord-003921-8r8z0otz	194	26	beneficial	beneficial	JJ
cord-003921-8r8z0otz	194	27	effects	effect	NNS
cord-003921-8r8z0otz	194	28	[	[	-LRB-
cord-003921-8r8z0otz	194	29	110	110	CD
cord-003921-8r8z0otz	194	30	,	,	,
cord-003921-8r8z0otz	194	31	111	111	CD
cord-003921-8r8z0otz	194	32	]	]	-RRB-
cord-003921-8r8z0otz	194	33	,	,	,
cord-003921-8r8z0otz	194	34	these	these	DT
cord-003921-8r8z0otz	194	35	investigations	investigation	NNS
cord-003921-8r8z0otz	194	36	are	be	VBP
cord-003921-8r8z0otz	194	37	clearly	clearly	RB
cord-003921-8r8z0otz	194	38	warranted	warrant	VBN
cord-003921-8r8z0otz	194	39	.	.	.
cord-003921-8r8z0otz	195	1	Although	although	IN
cord-003921-8r8z0otz	195	2	a	a	DT
cord-003921-8r8z0otz	195	3	number	number	NN
cord-003921-8r8z0otz	195	4	of	of	IN
cord-003921-8r8z0otz	195	5	recent	recent	JJ
cord-003921-8r8z0otz	195	6	studies	study	NNS
cord-003921-8r8z0otz	195	7	revealed	reveal	VBD
cord-003921-8r8z0otz	195	8	neutrophil	neutrophil	NNP
cord-003921-8r8z0otz	195	9	immunoregulatory	immunoregulatory	JJ
cord-003921-8r8z0otz	195	10	and	and	CC
cord-003921-8r8z0otz	195	11	tissue	tissue	NN
cord-003921-8r8z0otz	195	12	-	-	HYPH
cord-003921-8r8z0otz	195	13	repairing	repair	VBG
cord-003921-8r8z0otz	195	14	capabilities	capability	NNS
cord-003921-8r8z0otz	195	15	,	,	,
cord-003921-8r8z0otz	195	16	little	little	JJ
cord-003921-8r8z0otz	195	17	is	be	VBZ
cord-003921-8r8z0otz	195	18	known	know	VBN
cord-003921-8r8z0otz	195	19	about	about	IN
cord-003921-8r8z0otz	195	20	these	these	DT
cord-003921-8r8z0otz	195	21	functions	function	NNS
cord-003921-8r8z0otz	195	22	in	in	IN
cord-003921-8r8z0otz	195	23	liver	liver	NN
cord-003921-8r8z0otz	195	24	IRI	IRI	NNP
cord-003921-8r8z0otz	195	25	.	.	.
cord-003921-8r8z0otz	196	1	This	this	DT
cord-003921-8r8z0otz	196	2	might	may	MD
cord-003921-8r8z0otz	196	3	be	be	VB
cord-003921-8r8z0otz	196	4	due	due	JJ
cord-003921-8r8z0otz	196	5	to	to	IN
cord-003921-8r8z0otz	196	6	the	the	DT
cord-003921-8r8z0otz	196	7	overwhelming	overwhelming	JJ
cord-003921-8r8z0otz	196	8	focus	focus	NN
cord-003921-8r8z0otz	196	9	on	on	IN
cord-003921-8r8z0otz	196	10	the	the	DT
cord-003921-8r8z0otz	196	11	"	"	``
cord-003921-8r8z0otz	196	12	toxic	toxic	JJ
cord-003921-8r8z0otz	196	13	"	"	''
cord-003921-8r8z0otz	196	14	side	side	NN
cord-003921-8r8z0otz	196	15	of	of	IN
cord-003921-8r8z0otz	196	16	the	the	DT
cord-003921-8r8z0otz	196	17	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	196	18	biology	biology	NN
cord-003921-8r8z0otz	196	19	.	.	.
cord-003921-8r8z0otz	197	1	Although	although	IN
cord-003921-8r8z0otz	197	2	T	T	NNP
cord-003921-8r8z0otz	197	3	cells	cell	NNS
cord-003921-8r8z0otz	197	4	,	,	,
cord-003921-8r8z0otz	197	5	particularly	particularly	RB
cord-003921-8r8z0otz	197	6	of	of	IN
cord-003921-8r8z0otz	197	7	CD4	CD4	NNP
cord-003921-8r8z0otz	197	8	+	+	CC
cord-003921-8r8z0otz	197	9	phenotype	phenotype	NN
cord-003921-8r8z0otz	197	10	,	,	,
cord-003921-8r8z0otz	197	11	are	be	VBP
cord-003921-8r8z0otz	197	12	indispensable	indispensable	JJ
cord-003921-8r8z0otz	197	13	for	for	IN
cord-003921-8r8z0otz	197	14	the	the	DT
cord-003921-8r8z0otz	197	15	activation	activation	NN
cord-003921-8r8z0otz	197	16	/	/	SYM
cord-003921-8r8z0otz	197	17	regulation	regulation	NN
cord-003921-8r8z0otz	197	18	of	of	IN
cord-003921-8r8z0otz	197	19	sterile	sterile	JJ
cord-003921-8r8z0otz	197	20	inflammation	inflammation	NN
cord-003921-8r8z0otz	197	21	in	in	IN
cord-003921-8r8z0otz	197	22	liver	liver	NN
cord-003921-8r8z0otz	197	23	IRI	IRI	NNP
cord-003921-8r8z0otz	197	24	[	[	-LRB-
cord-003921-8r8z0otz	197	25	112	112	CD
cord-003921-8r8z0otz	197	26	,	,	,
cord-003921-8r8z0otz	197	27	113	113	CD
cord-003921-8r8z0otz	197	28	]	]	-RRB-
cord-003921-8r8z0otz	197	29	,	,	,
cord-003921-8r8z0otz	197	30	it	-PRON-	PRP
cord-003921-8r8z0otz	197	31	seems	seem	VBZ
cord-003921-8r8z0otz	197	32	that	that	IN
cord-003921-8r8z0otz	197	33	the	the	DT
cord-003921-8r8z0otz	197	34	presence	presence	NN
cord-003921-8r8z0otz	197	35	of	of	IN
cord-003921-8r8z0otz	197	36	CD4	CD4	NNP
cord-003921-8r8z0otz	197	37	+	+	CC
cord-003921-8r8z0otz	197	38	T	t	NN
cord-003921-8r8z0otz	197	39	cells	cell	NNS
cord-003921-8r8z0otz	197	40	per	per	IN
cord-003921-8r8z0otz	197	41	se	se	FW
cord-003921-8r8z0otz	197	42	rather	rather	RB
cord-003921-8r8z0otz	197	43	than	than	IN
cord-003921-8r8z0otz	197	44	Ag	Ag	NNP
cord-003921-8r8z0otz	197	45	-	-	HYPH
cord-003921-8r8z0otz	197	46	specific	specific	JJ
cord-003921-8r8z0otz	197	47	de	de	FW
cord-003921-8r8z0otz	197	48	novo	novo	NNP
cord-003921-8r8z0otz	197	49	T	T	NNP
cord-003921-8r8z0otz	197	50	cell	cell	NN
cord-003921-8r8z0otz	197	51	activation	activation	NN
cord-003921-8r8z0otz	197	52	is	be	VBZ
cord-003921-8r8z0otz	197	53	needed	need	VBN
cord-003921-8r8z0otz	197	54	for	for	IN
cord-003921-8r8z0otz	197	55	immune	immune	JJ
cord-003921-8r8z0otz	197	56	regulation	regulation	NN
cord-003921-8r8z0otz	197	57	[	[	-LRB-
cord-003921-8r8z0otz	197	58	114	114	CD
cord-003921-8r8z0otz	197	59	]	]	-RRB-
cord-003921-8r8z0otz	197	60	.	.	.
cord-003921-8r8z0otz	198	1	Hence	hence	RB
cord-003921-8r8z0otz	198	2	,	,	,
cord-003921-8r8z0otz	198	3	the	the	DT
cord-003921-8r8z0otz	198	4	ability	ability	NN
cord-003921-8r8z0otz	198	5	of	of	IN
cord-003921-8r8z0otz	198	6	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	198	7	to	to	TO
cord-003921-8r8z0otz	198	8	reduce	reduce	VB
cord-003921-8r8z0otz	198	9	T	T	NNP
cord-003921-8r8z0otz	198	10	cell	cell	NN
cord-003921-8r8z0otz	198	11	activation	activation	NN
cord-003921-8r8z0otz	198	12	may	may	MD
cord-003921-8r8z0otz	198	13	be	be	VB
cord-003921-8r8z0otz	198	14	insufficient	insufficient	JJ
cord-003921-8r8z0otz	198	15	to	to	TO
cord-003921-8r8z0otz	198	16	significantly	significantly	RB
cord-003921-8r8z0otz	198	17	impact	impact	VB
cord-003921-8r8z0otz	198	18	IRI	IRI	NNP
cord-003921-8r8z0otz	198	19	outcomes	outcome	NNS
cord-003921-8r8z0otz	198	20	.	.	.
cord-003921-8r8z0otz	199	1	In	in	IN
cord-003921-8r8z0otz	199	2	addition	addition	NN
cord-003921-8r8z0otz	199	3	,	,	,
cord-003921-8r8z0otz	199	4	the	the	DT
cord-003921-8r8z0otz	199	5	severe	severe	JJ
cord-003921-8r8z0otz	199	6	hepatocellular	hepatocellular	JJ
cord-003921-8r8z0otz	199	7	damage	damage	NN
cord-003921-8r8z0otz	199	8	produced	produce	VBN
cord-003921-8r8z0otz	199	9	in	in	IN
cord-003921-8r8z0otz	199	10	currently	currently	RB
cord-003921-8r8z0otz	199	11	used	use	VBN
cord-003921-8r8z0otz	199	12	murine	murine	JJ
cord-003921-8r8z0otz	199	13	IRI	IRI	NNP
cord-003921-8r8z0otz	199	14	models	model	NNS
cord-003921-8r8z0otz	199	15	may	may	MD
cord-003921-8r8z0otz	199	16	lead	lead	VB
cord-003921-8r8z0otz	199	17	to	to	IN
cord-003921-8r8z0otz	199	18	a	a	DT
cord-003921-8r8z0otz	199	19	failure	failure	NN
cord-003921-8r8z0otz	199	20	in	in	IN
cord-003921-8r8z0otz	199	21	detecting	detect	VBG
cord-003921-8r8z0otz	199	22	discrete	discrete	JJ
cord-003921-8r8z0otz	199	23	immunomodulatory	immunomodulatory	NN
cord-003921-8r8z0otz	199	24	and/or	and/or	CC
cord-003921-8r8z0otz	199	25	tissue	tissue	NN
cord-003921-8r8z0otz	199	26	-	-	HYPH
cord-003921-8r8z0otz	199	27	repairing	repair	VBG
cord-003921-8r8z0otz	199	28	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	199	29	functions	function	NNS
cord-003921-8r8z0otz	199	30	.	.	.
cord-003921-8r8z0otz	200	1	Future	future	JJ
cord-003921-8r8z0otz	200	2	studies	study	NNS
cord-003921-8r8z0otz	200	3	need	need	VBP
cord-003921-8r8z0otz	200	4	to	to	TO
cord-003921-8r8z0otz	200	5	focus	focus	VB
cord-003921-8r8z0otz	200	6	on	on	IN
cord-003921-8r8z0otz	200	7	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	200	8	involvement	involvement	NN
cord-003921-8r8z0otz	200	9	in	in	IN
cord-003921-8r8z0otz	200	10	the	the	DT
cord-003921-8r8z0otz	200	11	resolution	resolution	NN
cord-003921-8r8z0otz	200	12	of	of	IN
cord-003921-8r8z0otz	200	13	inflammation	inflammation	NN
cord-003921-8r8z0otz	200	14	and	and	CC
cord-003921-8r8z0otz	200	15	recreation	recreation	NN
cord-003921-8r8z0otz	200	16	of	of	IN
cord-003921-8r8z0otz	200	17	tissue	tissue	NN
cord-003921-8r8z0otz	200	18	homeostasis	homeostasis	NN
cord-003921-8r8z0otz	200	19	.	.	.
cord-003921-8r8z0otz	201	1	Experimental	experimental	JJ
cord-003921-8r8z0otz	201	2	evidence	evidence	NN
cord-003921-8r8z0otz	201	3	indicates	indicate	VBZ
cord-003921-8r8z0otz	201	4	the	the	DT
cord-003921-8r8z0otz	201	5	antiinflammatory	antiinflammatory	JJ
cord-003921-8r8z0otz	201	6	(	(	-LRB-
cord-003921-8r8z0otz	201	7	N2	n2	NN
cord-003921-8r8z0otz	201	8	)	)	-RRB-
cord-003921-8r8z0otz	201	9	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	201	10	polarization	polarization	NN
cord-003921-8r8z0otz	201	11	by	by	IN
cord-003921-8r8z0otz	201	12	TGFβ	TGFβ	NNP
cord-003921-8r8z0otz	201	13	,	,	,
cord-003921-8r8z0otz	201	14	IL4	il4	NN
cord-003921-8r8z0otz	201	15	or	or	CC
cord-003921-8r8z0otz	201	16	rosiglitazone	rosiglitazone	NN
cord-003921-8r8z0otz	201	17	[	[	-LRB-
cord-003921-8r8z0otz	201	18	75	75	CD
cord-003921-8r8z0otz	201	19	]	]	-RRB-
cord-003921-8r8z0otz	201	20	[	[	-LRB-
cord-003921-8r8z0otz	201	21	76	76	CD
cord-003921-8r8z0otz	201	22	]	]	-RRB-
cord-003921-8r8z0otz	201	23	[	[	-LRB-
cord-003921-8r8z0otz	201	24	77	77	CD
cord-003921-8r8z0otz	201	25	]	]	-RRB-
cord-003921-8r8z0otz	201	26	.	.	.
cord-003921-8r8z0otz	202	1	Although	although	IN
cord-003921-8r8z0otz	202	2	the	the	DT
cord-003921-8r8z0otz	202	3	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	202	4	plasticity	plasticity	NN
cord-003921-8r8z0otz	202	5	has	have	VBZ
cord-003921-8r8z0otz	202	6	not	not	RB
cord-003921-8r8z0otz	202	7	been	be	VBN
cord-003921-8r8z0otz	202	8	rigorously	rigorously	RB
cord-003921-8r8z0otz	202	9	proven	prove	VBN
cord-003921-8r8z0otz	202	10	,	,	,
cord-003921-8r8z0otz	202	11	the	the	DT
cord-003921-8r8z0otz	202	12	N1	N1	NNP
cord-003921-8r8z0otz	202	13	to	to	IN
cord-003921-8r8z0otz	202	14	N2	n2	NN
cord-003921-8r8z0otz	202	15	phenotype	phenotype	NN
cord-003921-8r8z0otz	202	16	shifting	shift	VBG
cord-003921-8r8z0otz	202	17	should	should	MD
cord-003921-8r8z0otz	202	18	be	be	VB
cord-003921-8r8z0otz	202	19	of	of	IN
cord-003921-8r8z0otz	202	20	a	a	DT
cord-003921-8r8z0otz	202	21	potential	potential	JJ
cord-003921-8r8z0otz	202	22	therapeutic	therapeutic	JJ
cord-003921-8r8z0otz	202	23	interest	interest	NN
cord-003921-8r8z0otz	202	24	.	.	.
cord-003921-8r8z0otz	203	1	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	203	2	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	203	3	is	be	VBZ
cord-003921-8r8z0otz	203	4	a	a	DT
cord-003921-8r8z0otz	203	5	favorable	favorable	JJ
cord-003921-8r8z0otz	203	6	way	way	NN
cord-003921-8r8z0otz	203	7	of	of	IN
cord-003921-8r8z0otz	203	8	its	-PRON-	PRP$
cord-003921-8r8z0otz	203	9	functional	functional	JJ
cord-003921-8r8z0otz	203	10	termination	termination	NN
cord-003921-8r8z0otz	203	11	,	,	,
cord-003921-8r8z0otz	203	12	leading	lead	VBG
cord-003921-8r8z0otz	203	13	to	to	IN
cord-003921-8r8z0otz	203	14	an	an	DT
cord-003921-8r8z0otz	203	15	immunomodulatory	immunomodulatory	JJ
cord-003921-8r8z0otz	203	16	shift	shift	NN
cord-003921-8r8z0otz	203	17	of	of	IN
cord-003921-8r8z0otz	203	18	phagocytosing	phagocytose	VBG
cord-003921-8r8z0otz	203	19	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	203	20	cells	cell	NNS
cord-003921-8r8z0otz	203	21	and	and	CC
cord-003921-8r8z0otz	203	22	prevention	prevention	NN
cord-003921-8r8z0otz	203	23	of	of	IN
cord-003921-8r8z0otz	203	24	the	the	DT
cord-003921-8r8z0otz	203	25	DAMPs	damp	NNS
cord-003921-8r8z0otz	203	26	burst	burst	NN
cord-003921-8r8z0otz	203	27	,	,	,
cord-003921-8r8z0otz	203	28	while	while	IN
cord-003921-8r8z0otz	203	29	excessive	excessive	JJ
cord-003921-8r8z0otz	203	30	induction	induction	NN
cord-003921-8r8z0otz	203	31	of	of	IN
cord-003921-8r8z0otz	203	32	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	203	33	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	203	34	may	may	MD
cord-003921-8r8z0otz	203	35	cause	cause	VB
cord-003921-8r8z0otz	203	36	unnecessary	unnecessary	JJ
cord-003921-8r8z0otz	203	37	immune	immune	JJ
cord-003921-8r8z0otz	203	38	suppression	suppression	NN
cord-003921-8r8z0otz	203	39	.	.	.
cord-003921-8r8z0otz	204	1	Indeed	indeed	RB
cord-003921-8r8z0otz	204	2	,	,	,
cord-003921-8r8z0otz	204	3	ectoine	ectoine	NNP
cord-003921-8r8z0otz	204	4	,	,	,
cord-003921-8r8z0otz	204	5	a	a	DT
cord-003921-8r8z0otz	204	6	natural	natural	JJ
cord-003921-8r8z0otz	204	7	cell	cell	NN
cord-003921-8r8z0otz	204	8	protectant	protectant	NN
cord-003921-8r8z0otz	204	9	,	,	,
cord-003921-8r8z0otz	204	10	improved	improve	VBD
cord-003921-8r8z0otz	204	11	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	204	12	resolution	resolution	NN
cord-003921-8r8z0otz	204	13	in	in	IN
cord-003921-8r8z0otz	204	14	a	a	DT
cord-003921-8r8z0otz	204	15	sterile	sterile	JJ
cord-003921-8r8z0otz	204	16	inflammation	inflammation	NN
cord-003921-8r8z0otz	204	17	lung	lung	NN
cord-003921-8r8z0otz	204	18	model	model	NN
cord-003921-8r8z0otz	204	19	by	by	IN
cord-003921-8r8z0otz	204	20	preferentially	preferentially	RB
cord-003921-8r8z0otz	204	21	prompting	prompt	VBG
cord-003921-8r8z0otz	204	22	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	204	23	in	in	IN
cord-003921-8r8z0otz	204	24	activated	activate	VBN
cord-003921-8r8z0otz	204	25	but	but	CC
cord-003921-8r8z0otz	204	26	not	not	RB
cord-003921-8r8z0otz	204	27	inactivated	inactivate	VBN
cord-003921-8r8z0otz	204	28	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	204	29	,	,	,
cord-003921-8r8z0otz	204	30	reducing	reduce	VBG
cord-003921-8r8z0otz	204	31	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	204	32	numbers	number	NNS
cord-003921-8r8z0otz	204	33	and	and	CC
cord-003921-8r8z0otz	204	34	improving	improve	VBG
cord-003921-8r8z0otz	204	35	resolution	resolution	NN
cord-003921-8r8z0otz	204	36	of	of	IN
cord-003921-8r8z0otz	204	37	the	the	DT
cord-003921-8r8z0otz	204	38	lung	lung	NN
cord-003921-8r8z0otz	204	39	pathology	pathology	NN
cord-003921-8r8z0otz	204	40	[	[	-LRB-
cord-003921-8r8z0otz	204	41	115	115	CD
cord-003921-8r8z0otz	204	42	]	]	-RRB-
cord-003921-8r8z0otz	204	43	.	.	.
cord-003921-8r8z0otz	205	1	Furthermore	furthermore	RB
cord-003921-8r8z0otz	205	2	,	,	,
cord-003921-8r8z0otz	205	3	a	a	DT
cord-003921-8r8z0otz	205	4	recent	recent	JJ
cord-003921-8r8z0otz	205	5	randomized	randomized	JJ
cord-003921-8r8z0otz	205	6	clinical	clinical	JJ
cord-003921-8r8z0otz	205	7	trial	trial	NN
cord-003921-8r8z0otz	205	8	in	in	IN
cord-003921-8r8z0otz	205	9	elderly	elderly	JJ
cord-003921-8r8z0otz	205	10	patients	patient	NNS
cord-003921-8r8z0otz	205	11	highlight	highlight	VBP
cord-003921-8r8z0otz	205	12	the	the	DT
cord-003921-8r8z0otz	205	13	efficacy	efficacy	NN
cord-003921-8r8z0otz	205	14	of	of	IN
cord-003921-8r8z0otz	205	15	inhaled	inhale	VBN
cord-003921-8r8z0otz	205	16	ectoine	ectoine	NN
cord-003921-8r8z0otz	205	17	in	in	IN
cord-003921-8r8z0otz	205	18	neutrophilic	neutrophilic	NNP
cord-003921-8r8z0otz	205	19	lung	lung	NNP
cord-003921-8r8z0otz	205	20	inflammation	inflammation	NN
cord-003921-8r8z0otz	205	21	[	[	-LRB-
cord-003921-8r8z0otz	205	22	116	116	CD
cord-003921-8r8z0otz	205	23	]	]	-RRB-
cord-003921-8r8z0otz	205	24	.	.	.
cord-003921-8r8z0otz	206	1	Studies	study	NNS
cord-003921-8r8z0otz	206	2	by	by	IN
cord-003921-8r8z0otz	206	3	Christoffersson	Christoffersson	NNP
cord-003921-8r8z0otz	206	4	et	et	NNP
cord-003921-8r8z0otz	206	5	al	al	NNP
cord-003921-8r8z0otz	206	6	.	.	NNP
cord-003921-8r8z0otz	206	7	have	have	VBP
cord-003921-8r8z0otz	206	8	identified	identify	VBN
cord-003921-8r8z0otz	206	9	VEGF	VEGF	NNP
cord-003921-8r8z0otz	206	10	-	-	HYPH
cord-003921-8r8z0otz	206	11	A	A	NNP
cord-003921-8r8z0otz	206	12	-	-	HYPH
cord-003921-8r8z0otz	206	13	induced	induce	VBN
cord-003921-8r8z0otz	206	14	CXCR4	cxcr4	NN
cord-003921-8r8z0otz	206	15	high	high	JJ
cord-003921-8r8z0otz	206	16	unique	unique	JJ
cord-003921-8r8z0otz	206	17	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	206	18	subset	subset	VBN
cord-003921-8r8z0otz	206	19	,	,	,
cord-003921-8r8z0otz	206	20	which	which	WDT
cord-003921-8r8z0otz	206	21	retained	retain	VBD
cord-003921-8r8z0otz	206	22	the	the	DT
cord-003921-8r8z0otz	206	23	ability	ability	NN
cord-003921-8r8z0otz	206	24	of	of	IN
cord-003921-8r8z0otz	206	25	revascularization	revascularization	NN
cord-003921-8r8z0otz	206	26	in	in	IN
cord-003921-8r8z0otz	206	27	a	a	DT
cord-003921-8r8z0otz	206	28	pancreatic	pancreatic	JJ
cord-003921-8r8z0otz	206	29	islet	islet	NN
cord-003921-8r8z0otz	206	30	transplant	transplant	NN
cord-003921-8r8z0otz	206	31	model	model	NN
cord-003921-8r8z0otz	206	32	[	[	-LRB-
cord-003921-8r8z0otz	206	33	86	86	CD
cord-003921-8r8z0otz	206	34	,	,	,
cord-003921-8r8z0otz	206	35	87	87	CD
cord-003921-8r8z0otz	206	36	]	]	-RRB-
cord-003921-8r8z0otz	206	37	,	,	,
cord-003921-8r8z0otz	206	38	while	while	IN
cord-003921-8r8z0otz	206	39	a	a	DT
cord-003921-8r8z0otz	206	40	study	study	NN
cord-003921-8r8z0otz	206	41	by	by	IN
cord-003921-8r8z0otz	206	42	Wang	Wang	NNP
cord-003921-8r8z0otz	206	43	et	et	NNP
cord-003921-8r8z0otz	206	44	al	al	NNP
cord-003921-8r8z0otz	206	45	.	.	.
cord-003921-8r8z0otz	207	1	[	[	-LRB-
cord-003921-8r8z0otz	207	2	83•	83•	NNP
cord-003921-8r8z0otz	207	3	]	]	-RRB-
cord-003921-8r8z0otz	207	4	implied	imply	VBD
cord-003921-8r8z0otz	207	5	CXCR4	CXCR4	NNS
cord-003921-8r8z0otz	207	6	expressing	express	VBG
cord-003921-8r8z0otz	207	7	noninflammatory	noninflammatory	JJ
cord-003921-8r8z0otz	207	8	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	207	9	subset	subset	VBN
cord-003921-8r8z0otz	207	10	capable	capable	JJ
cord-003921-8r8z0otz	207	11	of	of	IN
cord-003921-8r8z0otz	207	12	homing	home	VBG
cord-003921-8r8z0otz	207	13	back	back	RB
cord-003921-8r8z0otz	207	14	to	to	IN
cord-003921-8r8z0otz	207	15	bone	bone	NN
cord-003921-8r8z0otz	207	16	marrow	marrow	NN
cord-003921-8r8z0otz	207	17	in	in	IN
cord-003921-8r8z0otz	207	18	the	the	DT
cord-003921-8r8z0otz	207	19	"	"	``
cord-003921-8r8z0otz	207	20	reverse	reverse	JJ
cord-003921-8r8z0otz	207	21	migration	migration	NN
cord-003921-8r8z0otz	207	22	"	"	''
cord-003921-8r8z0otz	207	23	mechanism	mechanism	NN
cord-003921-8r8z0otz	207	24	[	[	-LRB-
cord-003921-8r8z0otz	207	25	117	117	CD
cord-003921-8r8z0otz	207	26	]	]	-RRB-
cord-003921-8r8z0otz	207	27	.	.	.
cord-003921-8r8z0otz	208	1	Thus	thus	RB
cord-003921-8r8z0otz	208	2	,	,	,
cord-003921-8r8z0otz	208	3	one	one	PRP
cord-003921-8r8z0otz	208	4	may	may	MD
cord-003921-8r8z0otz	208	5	envision	envision	VB
cord-003921-8r8z0otz	208	6	a	a	DT
cord-003921-8r8z0otz	208	7	great	great	JJ
cord-003921-8r8z0otz	208	8	potential	potential	NN
cord-003921-8r8z0otz	208	9	for	for	IN
cord-003921-8r8z0otz	208	10	future	future	JJ
cord-003921-8r8z0otz	208	11	regimens	regimen	NNS
cord-003921-8r8z0otz	208	12	shifting	shift	VBG
cord-003921-8r8z0otz	208	13	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	208	14	into	into	IN
cord-003921-8r8z0otz	208	15	tissue	tissue	NN
cord-003921-8r8z0otz	208	16	-	-	HYPH
cord-003921-8r8z0otz	208	17	resolving	resolve	VBG
cord-003921-8r8z0otz	208	18	CXCR4-positive	cxcr4-positive	VB
cord-003921-8r8z0otz	208	19	dominant	dominant	JJ
cord-003921-8r8z0otz	208	20	population	population	NN
cord-003921-8r8z0otz	208	21	.	.	.
cord-003921-8r8z0otz	209	1	Due	due	IN
cord-003921-8r8z0otz	209	2	to	to	IN
cord-003921-8r8z0otz	209	3	technological	technological	JJ
cord-003921-8r8z0otz	209	4	advances	advance	NNS
cord-003921-8r8z0otz	209	5	,	,	,
cord-003921-8r8z0otz	209	6	a	a	DT
cord-003921-8r8z0otz	209	7	remarkable	remarkable	JJ
cord-003921-8r8z0otz	209	8	progress	progress	NN
cord-003921-8r8z0otz	209	9	has	have	VBZ
cord-003921-8r8z0otz	209	10	been	be	VBN
cord-003921-8r8z0otz	209	11	recently	recently	RB
cord-003921-8r8z0otz	209	12	made	make	VBN
cord-003921-8r8z0otz	209	13	in	in	IN
cord-003921-8r8z0otz	209	14	our	-PRON-	PRP$
cord-003921-8r8z0otz	209	15	appreciation	appreciation	NN
cord-003921-8r8z0otz	209	16	of	of	IN
cord-003921-8r8z0otz	209	17	the	the	DT
cord-003921-8r8z0otz	209	18	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	209	19	biology	biology	NN
cord-003921-8r8z0otz	209	20	,	,	,
cord-003921-8r8z0otz	209	21	especially	especially	RB
cord-003921-8r8z0otz	209	22	its	-PRON-	PRP$
cord-003921-8r8z0otz	209	23	immune	immune	JJ
cord-003921-8r8z0otz	209	24	regulatory	regulatory	JJ
cord-003921-8r8z0otz	209	25	and	and	CC
cord-003921-8r8z0otz	209	26	tissue	tissue	NN
cord-003921-8r8z0otz	209	27	-	-	HYPH
cord-003921-8r8z0otz	209	28	repairing	repair	VBG
cord-003921-8r8z0otz	209	29	functions	function	NNS
cord-003921-8r8z0otz	209	30	.	.	.
cord-003921-8r8z0otz	210	1	Live	live	JJ
cord-003921-8r8z0otz	210	2	-	-	HYPH
cord-003921-8r8z0otz	210	3	cell	cell	NN
cord-003921-8r8z0otz	210	4	and	and	CC
cord-003921-8r8z0otz	210	5	deep	deep	JJ
cord-003921-8r8z0otz	210	6	-	-	HYPH
cord-003921-8r8z0otz	210	7	tissue	tissue	NN
cord-003921-8r8z0otz	210	8	imaging	imaging	NN
cord-003921-8r8z0otz	210	9	combined	combine	VBN
cord-003921-8r8z0otz	210	10	with	with	IN
cord-003921-8r8z0otz	210	11	single	single	JJ
cord-003921-8r8z0otz	210	12	cell	cell	NN
cord-003921-8r8z0otz	210	13	flow	flow	NN
cord-003921-8r8z0otz	210	14	cytometry	cytometry	NN
cord-003921-8r8z0otz	210	15	analyses	analysis	NNS
cord-003921-8r8z0otz	210	16	[	[	-LRB-
cord-003921-8r8z0otz	210	17	118	118	CD
cord-003921-8r8z0otz	210	18	]	]	-RRB-
cord-003921-8r8z0otz	210	19	allow	allow	VB
cord-003921-8r8z0otz	210	20	to	to	TO
cord-003921-8r8z0otz	210	21	accurately	accurately	RB
cord-003921-8r8z0otz	210	22	track	track	VB
cord-003921-8r8z0otz	210	23	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	210	24	functions	function	NNS
cord-003921-8r8z0otz	210	25	and	and	CC
cord-003921-8r8z0otz	210	26	interactions	interaction	NNS
cord-003921-8r8z0otz	210	27	in	in	IN
cord-003921-8r8z0otz	210	28	real	real	JJ
cord-003921-8r8z0otz	210	29	-	-	HYPH
cord-003921-8r8z0otz	210	30	time	time	NN
cord-003921-8r8z0otz	210	31	.	.	.
cord-003921-8r8z0otz	211	1	Unlike	unlike	IN
cord-003921-8r8z0otz	211	2	LysM	LysM	NNP
cord-003921-8r8z0otz	211	3	reporter	reporter	NN
cord-003921-8r8z0otz	211	4	mice	mouse	NNS
cord-003921-8r8z0otz	211	5	,	,	,
cord-003921-8r8z0otz	211	6	unable	unable	JJ
cord-003921-8r8z0otz	211	7	to	to	TO
cord-003921-8r8z0otz	211	8	distinguish	distinguish	VB
cord-003921-8r8z0otz	211	9	between	between	IN
cord-003921-8r8z0otz	211	10	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	211	11	and	and	CC
cord-003921-8r8z0otz	211	12	monocyte	monocyte	NNP
cord-003921-8r8z0otz	211	13	/	/	SYM
cord-003921-8r8z0otz	211	14	macrophage	macrophage	NN
cord-003921-8r8z0otz	211	15	lineages	lineage	NNS
cord-003921-8r8z0otz	211	16	,	,	,
cord-003921-8r8z0otz	211	17	a	a	DT
cord-003921-8r8z0otz	211	18	newly	newly	RB
cord-003921-8r8z0otz	211	19	developed	develop	VBN
cord-003921-8r8z0otz	211	20	murine	murine	JJ
cord-003921-8r8z0otz	211	21	strain	strain	NN
cord-003921-8r8z0otz	211	22	with	with	IN
cord-003921-8r8z0otz	211	23	a	a	DT
cord-003921-8r8z0otz	211	24	more	more	RBR
cord-003921-8r8z0otz	211	25	specific	specific	JJ
cord-003921-8r8z0otz	211	26	Ly6	ly6	CD
cord-003921-8r8z0otz	211	27	G	g	NN
cord-003921-8r8z0otz	211	28	promoter	promoter	NN
cord-003921-8r8z0otz	211	29	[	[	-LRB-
cord-003921-8r8z0otz	211	30	119	119	CD
cord-003921-8r8z0otz	211	31	]	]	-RRB-
cord-003921-8r8z0otz	211	32	has	have	VBZ
cord-003921-8r8z0otz	211	33	enabled	enable	VBN
cord-003921-8r8z0otz	211	34	to	to	TO
cord-003921-8r8z0otz	211	35	investigate	investigate	VB
cord-003921-8r8z0otz	211	36	in	in	IN
cord-003921-8r8z0otz	211	37	vivo	vivo	NN
cord-003921-8r8z0otz	211	38	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	211	39	functions	function	NNS
cord-003921-8r8z0otz	211	40	more	more	RBR
cord-003921-8r8z0otz	211	41	selectively	selectively	RB
cord-003921-8r8z0otz	211	42	and	and	CC
cord-003921-8r8z0otz	211	43	unequivocally	unequivocally	RB
cord-003921-8r8z0otz	211	44	.	.	.
cord-003921-8r8z0otz	212	1	Since	since	IN
cord-003921-8r8z0otz	212	2	efficient	efficient	JJ
cord-003921-8r8z0otz	212	3	strategies	strategy	NNS
cord-003921-8r8z0otz	212	4	against	against	IN
cord-003921-8r8z0otz	212	5	hepatic	hepatic	JJ
cord-003921-8r8z0otz	212	6	IRI	IRI	NNP
cord-003921-8r8z0otz	212	7	have	have	VBP
cord-003921-8r8z0otz	212	8	not	not	RB
cord-003921-8r8z0otz	212	9	been	be	VBN
cord-003921-8r8z0otz	212	10	yet	yet	RB
cord-003921-8r8z0otz	212	11	developed	develop	VBN
cord-003921-8r8z0otz	212	12	,	,	,
cord-003921-8r8z0otz	212	13	newly	newly	RB
cord-003921-8r8z0otz	212	14	discovered	discover	VBN
cord-003921-8r8z0otz	212	15	and	and	CC
cord-003921-8r8z0otz	212	16	therapeutically	therapeutically	RB
cord-003921-8r8z0otz	212	17	attractive	attractive	JJ
cord-003921-8r8z0otz	212	18	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	212	19	functions	function	NNS
cord-003921-8r8z0otz	212	20	,	,	,
cord-003921-8r8z0otz	212	21	as	as	IN
cord-003921-8r8z0otz	212	22	discussed	discuss	VBN
cord-003921-8r8z0otz	212	23	in	in	IN
cord-003921-8r8z0otz	212	24	this	this	DT
cord-003921-8r8z0otz	212	25	review	review	NN
cord-003921-8r8z0otz	212	26	,	,	,
cord-003921-8r8z0otz	212	27	warrant	warrant	VBP
cord-003921-8r8z0otz	212	28	future	future	JJ
cord-003921-8r8z0otz	212	29	comprehensive	comprehensive	JJ
cord-003921-8r8z0otz	212	30	preclinical	preclinical	JJ
cord-003921-8r8z0otz	212	31	and	and	CC
cord-003921-8r8z0otz	212	32	clinical	clinical	JJ
cord-003921-8r8z0otz	212	33	attention	attention	NN
cord-003921-8r8z0otz	212	34	in	in	IN
cord-003921-8r8z0otz	212	35	transplant	transplant	NN
cord-003921-8r8z0otz	212	36	recipients	recipient	NNS
cord-003921-8r8z0otz	212	37	.	.	.
cord-003921-8r8z0otz	213	1	Conflict	conflict	NN
cord-003921-8r8z0otz	213	2	of	of	IN
cord-003921-8r8z0otz	213	3	Interest	interest	NN
cord-003921-8r8z0otz	214	1	The	the	DT
cord-003921-8r8z0otz	214	2	authors	author	NNS
cord-003921-8r8z0otz	214	3	declare	declare	VBP
cord-003921-8r8z0otz	214	4	that	that	IN
cord-003921-8r8z0otz	214	5	they	-PRON-	PRP
cord-003921-8r8z0otz	214	6	have	have	VBP
cord-003921-8r8z0otz	214	7	no	no	DT
cord-003921-8r8z0otz	214	8	conflict	conflict	NN
cord-003921-8r8z0otz	214	9	of	of	IN
cord-003921-8r8z0otz	214	10	interest	interest	NN
cord-003921-8r8z0otz	214	11	.	.	.
cord-003921-8r8z0otz	215	1	Human	human	JJ
cord-003921-8r8z0otz	215	2	and	and	CC
cord-003921-8r8z0otz	215	3	Animal	Animal	NNP
cord-003921-8r8z0otz	215	4	Rights	Rights	NNPS
cord-003921-8r8z0otz	215	5	and	and	CC
cord-003921-8r8z0otz	215	6	Informed	Informed	NNP
cord-003921-8r8z0otz	215	7	Consent	Consent	NNP
cord-003921-8r8z0otz	216	1	This	this	DT
cord-003921-8r8z0otz	216	2	article	article	NN
cord-003921-8r8z0otz	216	3	does	do	VBZ
cord-003921-8r8z0otz	216	4	not	not	RB
cord-003921-8r8z0otz	216	5	contain	contain	VB
cord-003921-8r8z0otz	216	6	any	any	DT
cord-003921-8r8z0otz	216	7	studies	study	NNS
cord-003921-8r8z0otz	216	8	with	with	IN
cord-003921-8r8z0otz	216	9	human	human	JJ
cord-003921-8r8z0otz	216	10	or	or	CC
cord-003921-8r8z0otz	216	11	animal	animal	NN
cord-003921-8r8z0otz	216	12	subjects	subject	NNS
cord-003921-8r8z0otz	216	13	performed	perform	VBN
cord-003921-8r8z0otz	216	14	by	by	IN
cord-003921-8r8z0otz	216	15	any	any	DT
cord-003921-8r8z0otz	216	16	of	of	IN
cord-003921-8r8z0otz	216	17	the	the	DT
cord-003921-8r8z0otz	216	18	authors	author	NNS
cord-003921-8r8z0otz	216	19	.	.	.
cord-003921-8r8z0otz	217	1	Publisher	publisher	NN
cord-003921-8r8z0otz	217	2	's	's	POS
cord-003921-8r8z0otz	217	3	Note	Note	NNP
cord-003921-8r8z0otz	217	4	Springer	Springer	NNP
cord-003921-8r8z0otz	217	5	Nature	Nature	NNP
cord-003921-8r8z0otz	217	6	remains	remain	VBZ
cord-003921-8r8z0otz	217	7	neutral	neutral	JJ
cord-003921-8r8z0otz	217	8	with	with	IN
cord-003921-8r8z0otz	217	9	regard	regard	NN
cord-003921-8r8z0otz	217	10	to	to	IN
cord-003921-8r8z0otz	217	11	jurisdictional	jurisdictional	JJ
cord-003921-8r8z0otz	217	12	claims	claim	NNS
cord-003921-8r8z0otz	217	13	in	in	IN
cord-003921-8r8z0otz	217	14	published	publish	VBN
cord-003921-8r8z0otz	217	15	maps	map	NNS
cord-003921-8r8z0otz	217	16	and	and	CC
cord-003921-8r8z0otz	217	17	institutional	institutional	JJ
cord-003921-8r8z0otz	217	18	affiliations	affiliation	NNS
cord-003921-8r8z0otz	217	19	.	.	.
cord-003921-8r8z0otz	218	1	particular	particular	JJ
cord-003921-8r8z0otz	218	2	interest	interest	NN
cord-003921-8r8z0otz	218	3	,	,	,
cord-003921-8r8z0otz	218	4	published	publish	VBN
cord-003921-8r8z0otz	218	5	recently	recently	RB
cord-003921-8r8z0otz	218	6	,	,	,
cord-003921-8r8z0otz	218	7	have	have	VBP
cord-003921-8r8z0otz	218	8	been	be	VBN
cord-003921-8r8z0otz	218	9	highlighted	highlight	VBN
cord-003921-8r8z0otz	218	10	as	as	IN
cord-003921-8r8z0otz	218	11	:	:	:
cord-003921-8r8z0otz	218	12	•	•	.
cord-003921-8r8z0otz	219	1	Of	of	IN
cord-003921-8r8z0otz	219	2	importance	importance	NN
cord-003921-8r8z0otz	219	3	Challenges	challenge	NNS
cord-003921-8r8z0otz	219	4	to	to	IN
cord-003921-8r8z0otz	219	5	liver	liver	NN
cord-003921-8r8z0otz	219	6	transplantation	transplantation	NN
cord-003921-8r8z0otz	219	7	and	and	CC
cord-003921-8r8z0otz	219	8	strategies	strategy	NNS
cord-003921-8r8z0otz	219	9	to	to	TO
cord-003921-8r8z0otz	219	10	improve	improve	VB
cord-003921-8r8z0otz	219	11	outcomes	outcome	NNS
cord-003921-8r8z0otz	220	1	The	the	DT
cord-003921-8r8z0otz	220	2	utility	utility	NN
cord-003921-8r8z0otz	220	3	of	of	IN
cord-003921-8r8z0otz	220	4	marginal	marginal	JJ
cord-003921-8r8z0otz	220	5	donors	donor	NNS
cord-003921-8r8z0otz	220	6	in	in	IN
cord-003921-8r8z0otz	220	7	liver	liver	NN
cord-003921-8r8z0otz	220	8	transplantation	transplantation	NN
cord-003921-8r8z0otz	220	9	Ischaemia	ischaemia	NN
cord-003921-8r8z0otz	220	10	-	-	HYPH
cord-003921-8r8z0otz	220	11	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	220	12	injury	injury	NN
cord-003921-8r8z0otz	220	13	in	in	IN
cord-003921-8r8z0otz	220	14	liver	liver	NN
cord-003921-8r8z0otz	220	15	transplantation	transplantation	NN
cord-003921-8r8z0otz	220	16	-	-	,
cord-003921-8r8z0otz	220	17	from	from	IN
cord-003921-8r8z0otz	220	18	bench	bench	NN
cord-003921-8r8z0otz	220	19	to	to	IN
cord-003921-8r8z0otz	220	20	bedside	bedside	NN
cord-003921-8r8z0otz	220	21	Increased	increase	VBN
cord-003921-8r8z0otz	220	22	ischemic	ischemic	JJ
cord-003921-8r8z0otz	220	23	injury	injury	NN
cord-003921-8r8z0otz	220	24	in	in	IN
cord-003921-8r8z0otz	220	25	old	old	JJ
cord-003921-8r8z0otz	220	26	mouse	mouse	NN
cord-003921-8r8z0otz	220	27	liver	liver	NN
cord-003921-8r8z0otz	220	28	:	:	:
cord-003921-8r8z0otz	220	29	an	an	DT
cord-003921-8r8z0otz	220	30	ATP	ATP	NNP
cord-003921-8r8z0otz	220	31	-	-	HYPH
cord-003921-8r8z0otz	220	32	dependent	dependent	JJ
cord-003921-8r8z0otz	220	33	mechanism	mechanism	NN
cord-003921-8r8z0otz	220	34	Mechanisms	mechanism	NNS
cord-003921-8r8z0otz	220	35	of	of	IN
cord-003921-8r8z0otz	220	36	hepatic	hepatic	JJ
cord-003921-8r8z0otz	220	37	injury	injury	NN
cord-003921-8r8z0otz	220	38	and	and	CC
cord-003921-8r8z0otz	220	39	protective	protective	JJ
cord-003921-8r8z0otz	220	40	effects	effect	NNS
cord-003921-8r8z0otz	220	41	of	of	IN
cord-003921-8r8z0otz	220	42	nitric	nitric	NN
cord-003921-8r8z0otz	220	43	oxide	oxide	NN
cord-003921-8r8z0otz	220	44	Liver	liver	NN
cord-003921-8r8z0otz	220	45	ischemia	ischemia	NN
cord-003921-8r8z0otz	220	46	and	and	CC
cord-003921-8r8z0otz	220	47	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	220	48	injury	injury	NN
cord-003921-8r8z0otz	220	49	:	:	:
cord-003921-8r8z0otz	220	50	new	new	JJ
cord-003921-8r8z0otz	220	51	insights	insight	NNS
cord-003921-8r8z0otz	220	52	into	into	IN
cord-003921-8r8z0otz	220	53	mechanisms	mechanism	NNS
cord-003921-8r8z0otz	220	54	of	of	IN
cord-003921-8r8z0otz	220	55	innateadaptive	innateadaptive	JJ
cord-003921-8r8z0otz	220	56	immune	immune	NN
cord-003921-8r8z0otz	220	57	-	-	HYPH
cord-003921-8r8z0otz	220	58	mediated	mediate	VBN
cord-003921-8r8z0otz	220	59	tissue	tissue	NN
cord-003921-8r8z0otz	220	60	inflammation	inflammation	NN
cord-003921-8r8z0otz	221	1	Sirtuin	Sirtuin	NNP
cord-003921-8r8z0otz	221	2	1	1	CD
cord-003921-8r8z0otz	221	3	attenuates	attenuate	VBZ
cord-003921-8r8z0otz	221	4	inflammation	inflammation	NN
cord-003921-8r8z0otz	221	5	and	and	CC
cord-003921-8r8z0otz	221	6	hepatocellular	hepatocellular	JJ
cord-003921-8r8z0otz	221	7	damage	damage	NN
cord-003921-8r8z0otz	221	8	in	in	IN
cord-003921-8r8z0otz	221	9	liver	liver	NN
cord-003921-8r8z0otz	221	10	transplant	transplant	NN
cord-003921-8r8z0otz	221	11	ischemia	ischemia	NN
cord-003921-8r8z0otz	221	12	-	-	HYPH
cord-003921-8r8z0otz	221	13	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	221	14	:	:	:
cord-003921-8r8z0otz	221	15	from	from	IN
cord-003921-8r8z0otz	221	16	mouse	mouse	NN
cord-003921-8r8z0otz	221	17	-	-	HYPH
cord-003921-8r8z0otz	221	18	to	to	IN
cord-003921-8r8z0otz	221	19	-	-	HYPH
cord-003921-8r8z0otz	221	20	human	human	NN
cord-003921-8r8z0otz	221	21	The	the	DT
cord-003921-8r8z0otz	221	22	hepatic	hepatic	JJ
cord-003921-8r8z0otz	221	23	microcirculation	microcirculation	NN
cord-003921-8r8z0otz	221	24	:	:	:
cord-003921-8r8z0otz	221	25	mechanistic	mechanistic	JJ
cord-003921-8r8z0otz	221	26	contributions	contribution	NNS
cord-003921-8r8z0otz	221	27	and	and	CC
cord-003921-8r8z0otz	221	28	therapeutic	therapeutic	JJ
cord-003921-8r8z0otz	221	29	targets	target	NNS
cord-003921-8r8z0otz	221	30	in	in	IN
cord-003921-8r8z0otz	221	31	liver	liver	NN
cord-003921-8r8z0otz	221	32	injury	injury	NN
cord-003921-8r8z0otz	221	33	and	and	CC
cord-003921-8r8z0otz	221	34	repair	repair	NN
cord-003921-8r8z0otz	221	35	Tissue	tissue	NN
cord-003921-8r8z0otz	221	36	-	-	HYPH
cord-003921-8r8z0otz	221	37	resident	resident	NN
cord-003921-8r8z0otz	221	38	macrophages	macrophage	NNS
cord-003921-8r8z0otz	221	39	protect	protect	VBP
cord-003921-8r8z0otz	221	40	the	the	DT
cord-003921-8r8z0otz	221	41	liver	liver	NN
cord-003921-8r8z0otz	221	42	from	from	IN
cord-003921-8r8z0otz	221	43	ischemia	ischemia	NN
cord-003921-8r8z0otz	221	44	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	221	45	injury	injury	NN
cord-003921-8r8z0otz	221	46	via	via	IN
cord-003921-8r8z0otz	221	47	a	a	DT
cord-003921-8r8z0otz	221	48	heme	heme	JJ
cord-003921-8r8z0otz	221	49	oxygenase-1-dependent	oxygenase-1-dependent	NNP
cord-003921-8r8z0otz	221	50	mechanism	mechanism	NN
cord-003921-8r8z0otz	221	51	Heme	Heme	NNP
cord-003921-8r8z0otz	221	52	oxygenase-1	oxygenase-1	NNP
cord-003921-8r8z0otz	221	53	regulates	regulate	VBZ
cord-003921-8r8z0otz	221	54	sirtuin-1	sirtuin-1	NNP
cord-003921-8r8z0otz	221	55	-autophagy	-autophagy	NNP
cord-003921-8r8z0otz	221	56	pathway	pathway	NN
cord-003921-8r8z0otz	221	57	in	in	IN
cord-003921-8r8z0otz	221	58	liver	liver	NN
cord-003921-8r8z0otz	221	59	transplantation	transplantation	NN
cord-003921-8r8z0otz	221	60	:	:	:
cord-003921-8r8z0otz	222	1	from	from	IN
cord-003921-8r8z0otz	222	2	mouse	mouse	NN
cord-003921-8r8z0otz	222	3	-	-	HYPH
cord-003921-8r8z0otz	222	4	to	to	IN
cord-003921-8r8z0otz	222	5	-	-	HYPH
cord-003921-8r8z0otz	222	6	human	human	JJ
cord-003921-8r8z0otz	222	7	Recipient	Recipient	NNP
cord-003921-8r8z0otz	222	8	HO-1	HO-1	NNP
cord-003921-8r8z0otz	222	9	inducibility	inducibility	NNP
cord-003921-8r8z0otz	222	10	is	be	VBZ
cord-003921-8r8z0otz	222	11	essential	essential	JJ
cord-003921-8r8z0otz	222	12	for	for	IN
cord-003921-8r8z0otz	222	13	post	post	JJ
cord-003921-8r8z0otz	222	14	-	-	JJ
cord-003921-8r8z0otz	222	15	transplant	transplant	JJ
cord-003921-8r8z0otz	222	16	hepatic	hepatic	JJ
cord-003921-8r8z0otz	222	17	HO-1	HO-1	NNP
cord-003921-8r8z0otz	222	18	expression	expression	NN
cord-003921-8r8z0otz	222	19	and	and	CC
cord-003921-8r8z0otz	222	20	graft	graft	NN
cord-003921-8r8z0otz	222	21	protection	protection	NN
cord-003921-8r8z0otz	222	22	:	:	:
cord-003921-8r8z0otz	222	23	from	from	IN
cord-003921-8r8z0otz	223	1	bench	bench	NN
cord-003921-8r8z0otz	223	2	-	-	HYPH
cord-003921-8r8z0otz	223	3	to	to	IN
cord-003921-8r8z0otz	223	4	-	-	HYPH
cord-003921-8r8z0otz	223	5	bedside	bedside	NN
cord-003921-8r8z0otz	223	6	Macrophage	Macrophage	NNP
cord-003921-8r8z0otz	223	7	HO-1-SIRT1-p53	HO-1-SIRT1-p53	NNP
cord-003921-8r8z0otz	223	8	Axis	Axis	NNP
cord-003921-8r8z0otz	223	9	regulates	regulate	VBZ
cord-003921-8r8z0otz	223	10	sterile	sterile	JJ
cord-003921-8r8z0otz	223	11	inflammation	inflammation	NN
cord-003921-8r8z0otz	223	12	in	in	IN
cord-003921-8r8z0otz	223	13	liver	liver	NN
cord-003921-8r8z0otz	223	14	ischemia	ischemia	NN
cord-003921-8r8z0otz	223	15	-	-	HYPH
cord-003921-8r8z0otz	223	16	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	223	17	injury	injury	NN
cord-003921-8r8z0otz	224	1	Serelaxin	Serelaxin	NNP
cord-003921-8r8z0otz	224	2	induces	induce	VBZ
cord-003921-8r8z0otz	224	3	Notch1	Notch1	NNP
cord-003921-8r8z0otz	224	4	signaling	signal	VBG
cord-003921-8r8z0otz	224	5	and	and	CC
cord-003921-8r8z0otz	224	6	alleviates	alleviate	VBZ
cord-003921-8r8z0otz	224	7	hepatocellular	hepatocellular	JJ
cord-003921-8r8z0otz	224	8	damage	damage	NN
cord-003921-8r8z0otz	224	9	in	in	IN
cord-003921-8r8z0otz	224	10	orthotopic	orthotopic	JJ
cord-003921-8r8z0otz	224	11	liver	liver	NN
cord-003921-8r8z0otz	224	12	transplantation	transplantation	NN
cord-003921-8r8z0otz	224	13	Of	of	IN
cord-003921-8r8z0otz	224	14	mice	mouse	NNS
cord-003921-8r8z0otz	224	15	and	and	CC
cord-003921-8r8z0otz	224	16	not	not	RB
cord-003921-8r8z0otz	224	17	men	man	NNS
cord-003921-8r8z0otz	224	18	:	:	:
cord-003921-8r8z0otz	224	19	differences	difference	NNS
cord-003921-8r8z0otz	224	20	between	between	IN
cord-003921-8r8z0otz	224	21	mouse	mouse	NN
cord-003921-8r8z0otz	224	22	and	and	CC
cord-003921-8r8z0otz	224	23	human	human	JJ
cord-003921-8r8z0otz	224	24	immunology	immunology	NN
cord-003921-8r8z0otz	224	25	Gender	gender	NN
cord-003921-8r8z0otz	224	26	dimorphism	dimorphism	NN
cord-003921-8r8z0otz	224	27	in	in	IN
cord-003921-8r8z0otz	224	28	differential	differential	JJ
cord-003921-8r8z0otz	224	29	peripheral	peripheral	JJ
cord-003921-8r8z0otz	224	30	blood	blood	NN
cord-003921-8r8z0otz	224	31	leukocyte	leukocyte	NN
cord-003921-8r8z0otz	224	32	counts	count	VBZ
cord-003921-8r8z0otz	224	33	in	in	IN
cord-003921-8r8z0otz	224	34	mice	mouse	NNS
cord-003921-8r8z0otz	224	35	using	use	VBG
cord-003921-8r8z0otz	224	36	cardiac	cardiac	NN
cord-003921-8r8z0otz	224	37	,	,	,
cord-003921-8r8z0otz	224	38	tail	tail	NN
cord-003921-8r8z0otz	224	39	,	,	,
cord-003921-8r8z0otz	224	40	foot	foot	NN
cord-003921-8r8z0otz	224	41	,	,	,
cord-003921-8r8z0otz	224	42	and	and	CC
cord-003921-8r8z0otz	224	43	saphenous	saphenous	JJ
cord-003921-8r8z0otz	224	44	vein	vein	NN
cord-003921-8r8z0otz	224	45	puncture	puncture	NN
cord-003921-8r8z0otz	224	46	methods	method	NNS
cord-003921-8r8z0otz	224	47	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	224	48	recruitment	recruitment	NN
cord-003921-8r8z0otz	224	49	and	and	CC
cord-003921-8r8z0otz	224	50	function	function	NN
cord-003921-8r8z0otz	224	51	in	in	IN
cord-003921-8r8z0otz	224	52	health	health	NN
cord-003921-8r8z0otz	224	53	and	and	CC
cord-003921-8r8z0otz	224	54	inflammation	inflammation	NN
cord-003921-8r8z0otz	224	55	Neutrophils	Neutrophils	NNP
cord-003921-8r8z0otz	224	56	-	-	:
cord-003921-8r8z0otz	224	57	a	a	DT
cord-003921-8r8z0otz	224	58	key	key	JJ
cord-003921-8r8z0otz	224	59	component	component	NN
cord-003921-8r8z0otz	224	60	of	of	IN
cord-003921-8r8z0otz	224	61	ischemia	ischemia	NN
cord-003921-8r8z0otz	224	62	-	-	HYPH
cord-003921-8r8z0otz	224	63	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	224	64	injury	injury	NN
cord-003921-8r8z0otz	225	1	Recombinant	recombinant	JJ
cord-003921-8r8z0otz	225	2	relaxin	relaxin	NN
cord-003921-8r8z0otz	225	3	protects	protect	VBZ
cord-003921-8r8z0otz	225	4	liver	liver	NN
cord-003921-8r8z0otz	225	5	transplants	transplant	NNS
cord-003921-8r8z0otz	225	6	from	from	IN
cord-003921-8r8z0otz	225	7	ischemia	ischemia	NN
cord-003921-8r8z0otz	225	8	damage	damage	NN
cord-003921-8r8z0otz	225	9	via	via	IN
cord-003921-8r8z0otz	225	10	hepatocyte	hepatocyte	NN
cord-003921-8r8z0otz	225	11	glucocorticoid	glucocorticoid	NN
cord-003921-8r8z0otz	225	12	receptor	receptor	NN
cord-003921-8r8z0otz	225	13	:	:	:
cord-003921-8r8z0otz	225	14	from	from	IN
cord-003921-8r8z0otz	225	15	bench	bench	NN
cord-003921-8r8z0otz	225	16	-	-	HYPH
cord-003921-8r8z0otz	225	17	to	to	IN
cord-003921-8r8z0otz	225	18	-	-	HYPH
cord-003921-8r8z0otz	225	19	bedside	bedside	NN
cord-003921-8r8z0otz	225	20	Neutrophils	Neutrophils	NNP
cord-003921-8r8z0otz	225	21	,	,	,
cord-003921-8r8z0otz	225	22	from	from	IN
cord-003921-8r8z0otz	225	23	marrow	marrow	NN
cord-003921-8r8z0otz	225	24	to	to	IN
cord-003921-8r8z0otz	225	25	microbes	microbe	NNS
cord-003921-8r8z0otz	225	26	Sterile	sterile	JJ
cord-003921-8r8z0otz	225	27	inflammation	inflammation	NN
cord-003921-8r8z0otz	225	28	in	in	IN
cord-003921-8r8z0otz	225	29	the	the	DT
cord-003921-8r8z0otz	225	30	liver	liver	NN
cord-003921-8r8z0otz	226	1	Intravascular	Intravascular	NNP
cord-003921-8r8z0otz	226	2	danger	danger	NN
cord-003921-8r8z0otz	226	3	signals	signal	NNS
cord-003921-8r8z0otz	226	4	guide	guide	VBP
cord-003921-8r8z0otz	226	5	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	226	6	to	to	IN
cord-003921-8r8z0otz	226	7	sites	site	NNS
cord-003921-8r8z0otz	226	8	of	of	IN
cord-003921-8r8z0otz	226	9	sterile	sterile	JJ
cord-003921-8r8z0otz	226	10	inflammation	inflammation	NN
cord-003921-8r8z0otz	227	1	Acetaminopheninduced	acetaminopheninduced	JJ
cord-003921-8r8z0otz	227	2	hepatotoxicity	hepatotoxicity	NN
cord-003921-8r8z0otz	227	3	in	in	IN
cord-003921-8r8z0otz	227	4	mice	mouse	NNS
cord-003921-8r8z0otz	227	5	is	be	VBZ
cord-003921-8r8z0otz	227	6	dependent	dependent	JJ
cord-003921-8r8z0otz	227	7	on	on	IN
cord-003921-8r8z0otz	227	8	Tlr9	Tlr9	NNP
cord-003921-8r8z0otz	227	9	and	and	CC
cord-003921-8r8z0otz	227	10	the	the	DT
cord-003921-8r8z0otz	227	11	Nalp3	Nalp3	NNP
cord-003921-8r8z0otz	227	12	inflammasome	inflammasome	NNP
cord-003921-8r8z0otz	227	13	Functional	functional	JJ
cord-003921-8r8z0otz	227	14	inactivation	inactivation	NN
cord-003921-8r8z0otz	227	15	of	of	IN
cord-003921-8r8z0otz	227	16	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	227	17	with	with	IN
cord-003921-8r8z0otz	227	18	a	a	DT
cord-003921-8r8z0otz	227	19	Mac-1	Mac-1	NNP
cord-003921-8r8z0otz	227	20	(	(	-LRB-
cord-003921-8r8z0otz	227	21	CD11b	CD11b	NNPS
cord-003921-8r8z0otz	227	22	/	/	SYM
cord-003921-8r8z0otz	227	23	CD18	CD18	NNP
cord-003921-8r8z0otz	227	24	)	)	-RRB-
cord-003921-8r8z0otz	227	25	monoclonal	monoclonal	JJ
cord-003921-8r8z0otz	227	26	antibody	antibody	NN
cord-003921-8r8z0otz	227	27	protects	protect	VBZ
cord-003921-8r8z0otz	227	28	against	against	IN
cord-003921-8r8z0otz	227	29	ischemiareperfusion	ischemiareperfusion	NN
cord-003921-8r8z0otz	227	30	injury	injury	NN
cord-003921-8r8z0otz	227	31	in	in	IN
cord-003921-8r8z0otz	227	32	rat	rat	NN
cord-003921-8r8z0otz	227	33	liver	liver	NN
cord-003921-8r8z0otz	227	34	Efficacy	Efficacy	NNP
cord-003921-8r8z0otz	227	35	of	of	IN
cord-003921-8r8z0otz	227	36	intraportal	intraportal	NNP
cord-003921-8r8z0otz	227	37	injection	injection	NN
cord-003921-8r8z0otz	227	38	of	of	IN
cord-003921-8r8z0otz	227	39	anti	anti	JJ
cord-003921-8r8z0otz	227	40	-	-	JJ
cord-003921-8r8z0otz	227	41	ICAM-1	icam-1	JJ
cord-003921-8r8z0otz	227	42	monoclonal	monoclonal	JJ
cord-003921-8r8z0otz	227	43	antibody	antibody	NN
cord-003921-8r8z0otz	227	44	against	against	IN
cord-003921-8r8z0otz	227	45	liver	liver	NN
cord-003921-8r8z0otz	227	46	cell	cell	NN
cord-003921-8r8z0otz	227	47	injury	injury	NN
cord-003921-8r8z0otz	227	48	following	follow	VBG
cord-003921-8r8z0otz	227	49	warm	warm	JJ
cord-003921-8r8z0otz	227	50	ischemia	ischemia	NN
cord-003921-8r8z0otz	227	51	in	in	IN
cord-003921-8r8z0otz	227	52	the	the	DT
cord-003921-8r8z0otz	227	53	rat	rat	NN
cord-003921-8r8z0otz	227	54	Endogenous	endogenous	JJ
cord-003921-8r8z0otz	227	55	histones	histone	NNS
cord-003921-8r8z0otz	227	56	function	function	VBP
cord-003921-8r8z0otz	227	57	as	as	IN
cord-003921-8r8z0otz	227	58	alarmins	alarmin	NNS
cord-003921-8r8z0otz	227	59	in	in	IN
cord-003921-8r8z0otz	227	60	sterile	sterile	JJ
cord-003921-8r8z0otz	227	61	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	227	62	liver	liver	NN
cord-003921-8r8z0otz	227	63	injury	injury	NN
cord-003921-8r8z0otz	227	64	through	through	IN
cord-003921-8r8z0otz	227	65	Toll	Toll	NNP
cord-003921-8r8z0otz	227	66	-	-	HYPH
cord-003921-8r8z0otz	227	67	like	like	JJ
cord-003921-8r8z0otz	227	68	receptor	receptor	NN
cord-003921-8r8z0otz	227	69	9	9	CD
cord-003921-8r8z0otz	227	70	in	in	IN
cord-003921-8r8z0otz	227	71	mice	mouse	NNS
cord-003921-8r8z0otz	228	1	The	the	DT
cord-003921-8r8z0otz	228	2	nuclear	nuclear	JJ
cord-003921-8r8z0otz	228	3	factor	factor	NN
cord-003921-8r8z0otz	228	4	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	228	5	mediates	mediate	VBZ
cord-003921-8r8z0otz	228	6	hepatic	hepatic	JJ
cord-003921-8r8z0otz	228	7	injury	injury	NN
cord-003921-8r8z0otz	228	8	after	after	IN
cord-003921-8r8z0otz	228	9	murine	murine	JJ
cord-003921-8r8z0otz	228	10	liver	liver	NN
cord-003921-8r8z0otz	228	11	ischemia	ischemia	NN
cord-003921-8r8z0otz	228	12	-	-	HYPH
cord-003921-8r8z0otz	228	13	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	229	1	Thrombomodulin	Thrombomodulin	NNP
cord-003921-8r8z0otz	229	2	attenuates	attenuate	VBZ
cord-003921-8r8z0otz	229	3	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	229	4	damage	damage	NN
cord-003921-8r8z0otz	229	5	due	due	IN
cord-003921-8r8z0otz	229	6	to	to	IN
cord-003921-8r8z0otz	229	7	liver	liver	NN
cord-003921-8r8z0otz	229	8	ischemia	ischemia	NN
cord-003921-8r8z0otz	229	9	and	and	CC
cord-003921-8r8z0otz	229	10	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	229	11	injury	injury	NN
cord-003921-8r8z0otz	229	12	in	in	IN
cord-003921-8r8z0otz	229	13	mice	mouse	NNS
cord-003921-8r8z0otz	229	14	in	in	IN
cord-003921-8r8z0otz	229	15	Toll	Toll	NNP
cord-003921-8r8z0otz	229	16	-	-	HYPH
cord-003921-8r8z0otz	229	17	like	like	JJ
cord-003921-8r8z0otz	229	18	receptor	receptor	NN
cord-003921-8r8z0otz	229	19	4-dependent	4-dependent	CD
cord-003921-8r8z0otz	229	20	manner	manner	NN
cord-003921-8r8z0otz	230	1	The	the	DT
cord-003921-8r8z0otz	230	2	HMGB1	HMGB1	NNP
cord-003921-8r8z0otz	230	3	/	/	SYM
cord-003921-8r8z0otz	230	4	RAGE	rage	NN
cord-003921-8r8z0otz	230	5	axis	axis	NN
cord-003921-8r8z0otz	230	6	triggers	trigger	VBZ
cord-003921-8r8z0otz	230	7	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	230	8	-	-	HYPH
cord-003921-8r8z0otz	230	9	mediated	mediate	VBN
cord-003921-8r8z0otz	230	10	injury	injury	NN
cord-003921-8r8z0otz	230	11	amplification	amplification	NN
cord-003921-8r8z0otz	230	12	following	follow	VBG
cord-003921-8r8z0otz	230	13	necrosis	necrosis	NN
cord-003921-8r8z0otz	230	14	Hepatocyte	Hepatocyte	NNP
cord-003921-8r8z0otz	230	15	-	-	HYPH
cord-003921-8r8z0otz	230	16	specific	specific	JJ
cord-003921-8r8z0otz	230	17	high	high	JJ
cord-003921-8r8z0otz	230	18	-	-	HYPH
cord-003921-8r8z0otz	230	19	mobility	mobility	NN
cord-003921-8r8z0otz	230	20	group	group	NN
cord-003921-8r8z0otz	230	21	box	box	NN
cord-003921-8r8z0otz	230	22	1	1	CD
cord-003921-8r8z0otz	230	23	deletion	deletion	NN
cord-003921-8r8z0otz	230	24	worsens	worsen	VBZ
cord-003921-8r8z0otz	230	25	the	the	DT
cord-003921-8r8z0otz	230	26	injury	injury	NN
cord-003921-8r8z0otz	230	27	in	in	IN
cord-003921-8r8z0otz	230	28	liver	liver	NN
cord-003921-8r8z0otz	230	29	ischemia	ischemia	NN
cord-003921-8r8z0otz	230	30	/	/	SYM
cord-003921-8r8z0otz	230	31	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	230	32	:	:	:
cord-003921-8r8z0otz	230	33	a	a	DT
cord-003921-8r8z0otz	230	34	role	role	NN
cord-003921-8r8z0otz	230	35	for	for	IN
cord-003921-8r8z0otz	230	36	intracellular	intracellular	JJ
cord-003921-8r8z0otz	230	37	high	high	JJ
cord-003921-8r8z0otz	230	38	-	-	HYPH
cord-003921-8r8z0otz	230	39	mobility	mobility	NN
cord-003921-8r8z0otz	230	40	group	group	NN
cord-003921-8r8z0otz	230	41	box	box	NN
cord-003921-8r8z0otz	230	42	1	1	CD
cord-003921-8r8z0otz	230	43	in	in	IN
cord-003921-8r8z0otz	230	44	cellular	cellular	JJ
cord-003921-8r8z0otz	230	45	protection	protection	NN
cord-003921-8r8z0otz	231	1	Intravital	intravital	JJ
cord-003921-8r8z0otz	231	2	microscopic	microscopic	JJ
cord-003921-8r8z0otz	231	3	evaluation	evaluation	NN
cord-003921-8r8z0otz	231	4	of	of	IN
cord-003921-8r8z0otz	231	5	the	the	DT
cord-003921-8r8z0otz	231	6	effects	effect	NNS
cord-003921-8r8z0otz	231	7	of	of	IN
cord-003921-8r8z0otz	231	8	a	a	DT
cord-003921-8r8z0otz	231	9	CXCR2	CXCR2	NNS
cord-003921-8r8z0otz	231	10	antagonist	antagonist	NN
cord-003921-8r8z0otz	231	11	in	in	IN
cord-003921-8r8z0otz	231	12	a	a	DT
cord-003921-8r8z0otz	231	13	model	model	NN
cord-003921-8r8z0otz	231	14	of	of	IN
cord-003921-8r8z0otz	231	15	liver	liver	NN
cord-003921-8r8z0otz	231	16	ischemia	ischemia	NN
cord-003921-8r8z0otz	231	17	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	231	18	injury	injury	NN
cord-003921-8r8z0otz	231	19	in	in	IN
cord-003921-8r8z0otz	231	20	mice	mouse	NNS
cord-003921-8r8z0otz	232	1	Kupffer	Kupffer	NNP
cord-003921-8r8z0otz	232	2	cellderived	cellderived	NNP
cord-003921-8r8z0otz	233	1	TNF	tnf	NN
cord-003921-8r8z0otz	233	2	-	-	HYPH
cord-003921-8r8z0otz	233	3	alpha	alpha	NN
cord-003921-8r8z0otz	233	4	promotes	promote	VBZ
cord-003921-8r8z0otz	233	5	hepatocytes	hepatocyte	NNS
cord-003921-8r8z0otz	233	6	to	to	TO
cord-003921-8r8z0otz	233	7	produce	produce	VB
cord-003921-8r8z0otz	233	8	CXCL1	cxcl1	NN
cord-003921-8r8z0otz	233	9	and	and	CC
cord-003921-8r8z0otz	233	10	mobilize	mobilize	VB
cord-003921-8r8z0otz	233	11	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	233	12	in	in	IN
cord-003921-8r8z0otz	233	13	response	response	NN
cord-003921-8r8z0otz	233	14	to	to	IN
cord-003921-8r8z0otz	233	15	necrotic	necrotic	JJ
cord-003921-8r8z0otz	233	16	cells	cell	NNS
cord-003921-8r8z0otz	234	1	A	a	DT
cord-003921-8r8z0otz	234	2	TLR2	TLR2	NNP
cord-003921-8r8z0otz	234	3	/	/	SYM
cord-003921-8r8z0otz	234	4	S100A9	S100A9	NNP
cord-003921-8r8z0otz	234	5	/	/	SYM
cord-003921-8r8z0otz	234	6	CXCL-2	CXCL-2	NNP
cord-003921-8r8z0otz	235	1	signaling	signal	VBG
cord-003921-8r8z0otz	235	2	network	network	NN
cord-003921-8r8z0otz	235	3	is	be	VBZ
cord-003921-8r8z0otz	235	4	necessary	necessary	JJ
cord-003921-8r8z0otz	235	5	for	for	IN
cord-003921-8r8z0otz	235	6	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	235	7	recruitment	recruitment	NN
cord-003921-8r8z0otz	235	8	in	in	IN
cord-003921-8r8z0otz	235	9	acute	acute	JJ
cord-003921-8r8z0otz	235	10	and	and	CC
cord-003921-8r8z0otz	235	11	chronic	chronic	JJ
cord-003921-8r8z0otz	235	12	liver	liver	NN
cord-003921-8r8z0otz	235	13	injury	injury	NN
cord-003921-8r8z0otz	235	14	in	in	IN
cord-003921-8r8z0otz	235	15	the	the	DT
cord-003921-8r8z0otz	235	16	mouse	mouse	NN
cord-003921-8r8z0otz	235	17	Circulating	circulate	VBG
cord-003921-8r8z0otz	235	18	mitochondrial	mitochondrial	NN
cord-003921-8r8z0otz	235	19	DAMPs	damp	NNS
cord-003921-8r8z0otz	235	20	cause	cause	VBP
cord-003921-8r8z0otz	235	21	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	235	22	responses	response	NNS
cord-003921-8r8z0otz	235	23	to	to	TO
cord-003921-8r8z0otz	235	24	injury	injury	VB
cord-003921-8r8z0otz	235	25	Intravital	Intravital	NNP
cord-003921-8r8z0otz	235	26	imaging	imaging	NN
cord-003921-8r8z0otz	235	27	of	of	IN
cord-003921-8r8z0otz	235	28	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	235	29	recruitment	recruitment	NN
cord-003921-8r8z0otz	235	30	reveals	reveal	VBZ
cord-003921-8r8z0otz	235	31	the	the	DT
cord-003921-8r8z0otz	235	32	efficacy	efficacy	NN
cord-003921-8r8z0otz	235	33	of	of	IN
cord-003921-8r8z0otz	235	34	FPR1	FPR1	NNP
cord-003921-8r8z0otz	235	35	blockade	blockade	NN
cord-003921-8r8z0otz	235	36	in	in	IN
cord-003921-8r8z0otz	235	37	hepatic	hepatic	JJ
cord-003921-8r8z0otz	235	38	ischemia	ischemia	NN
cord-003921-8r8z0otz	235	39	-	-	HYPH
cord-003921-8r8z0otz	235	40	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	235	41	injury	injury	NN
cord-003921-8r8z0otz	236	1	This	this	DT
cord-003921-8r8z0otz	236	2	study	study	NN
cord-003921-8r8z0otz	236	3	revealed	reveal	VBD
cord-003921-8r8z0otz	236	4	the	the	DT
cord-003921-8r8z0otz	236	5	efficacy	efficacy	NN
cord-003921-8r8z0otz	236	6	of	of	IN
cord-003921-8r8z0otz	236	7	FPR1	FPR1	NNP
cord-003921-8r8z0otz	236	8	antagonist	antagonist	NN
cord-003921-8r8z0otz	236	9	to	to	TO
cord-003921-8r8z0otz	236	10	inhibit	inhibit	VB
cord-003921-8r8z0otz	236	11	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	236	12	migration	migration	NN
cord-003921-8r8z0otz	236	13	and	and	CC
cord-003921-8r8z0otz	236	14	alleviate	alleviate	VB
cord-003921-8r8z0otz	236	15	liver	liver	NN
cord-003921-8r8z0otz	236	16	IRI	IRI	NNP
cord-003921-8r8z0otz	237	1	An	an	DT
cord-003921-8r8z0otz	237	2	intracellular	intracellular	JJ
cord-003921-8r8z0otz	237	3	signaling	signaling	NN
cord-003921-8r8z0otz	237	4	hierarchy	hierarchy	NN
cord-003921-8r8z0otz	237	5	determines	determine	VBZ
cord-003921-8r8z0otz	237	6	direction	direction	NN
cord-003921-8r8z0otz	237	7	of	of	IN
cord-003921-8r8z0otz	237	8	migration	migration	NN
cord-003921-8r8z0otz	237	9	in	in	IN
cord-003921-8r8z0otz	237	10	opposing	oppose	VBG
cord-003921-8r8z0otz	237	11	chemotactic	chemotactic	JJ
cord-003921-8r8z0otz	237	12	gradients	gradient	NNS
cord-003921-8r8z0otz	237	13	Chemokines	Chemokines	NNPS
cord-003921-8r8z0otz	237	14	and	and	CC
cord-003921-8r8z0otz	237	15	mitochondrial	mitochondrial	JJ
cord-003921-8r8z0otz	237	16	products	product	NNS
cord-003921-8r8z0otz	237	17	activate	activate	VBP
cord-003921-8r8z0otz	237	18	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	237	19	to	to	TO
cord-003921-8r8z0otz	237	20	amplify	amplify	VB
cord-003921-8r8z0otz	237	21	organ	organ	NN
cord-003921-8r8z0otz	237	22	injury	injury	NN
cord-003921-8r8z0otz	237	23	during	during	IN
cord-003921-8r8z0otz	237	24	mouse	mouse	NN
cord-003921-8r8z0otz	237	25	acute	acute	JJ
cord-003921-8r8z0otz	237	26	liver	liver	NN
cord-003921-8r8z0otz	237	27	failure	failure	NN
cord-003921-8r8z0otz	237	28	Matrix	Matrix	NNP
cord-003921-8r8z0otz	237	29	metalloproteinase-2	metalloproteinase-2	NNP
cord-003921-8r8z0otz	237	30	(	(	-LRB-
cord-003921-8r8z0otz	237	31	MMP-2	MMP-2	NNP
cord-003921-8r8z0otz	237	32	)	)	-RRB-
cord-003921-8r8z0otz	238	1	gene	gene	NN
cord-003921-8r8z0otz	238	2	deletion	deletion	NN
cord-003921-8r8z0otz	238	3	enhances	enhance	VBZ
cord-003921-8r8z0otz	238	4	MMP-9	MMP-9	NNP
cord-003921-8r8z0otz	238	5	activity	activity	NN
cord-003921-8r8z0otz	238	6	,	,	,
cord-003921-8r8z0otz	238	7	impairs	impair	VBZ
cord-003921-8r8z0otz	238	8	PARP-1	parp-1	JJ
cord-003921-8r8z0otz	238	9	degradation	degradation	NN
cord-003921-8r8z0otz	238	10	,	,	,
cord-003921-8r8z0otz	238	11	and	and	CC
cord-003921-8r8z0otz	238	12	exacerbates	exacerbate	VBZ
cord-003921-8r8z0otz	238	13	hepatic	hepatic	JJ
cord-003921-8r8z0otz	238	14	ischemia	ischemia	NN
cord-003921-8r8z0otz	238	15	and	and	CC
cord-003921-8r8z0otz	238	16	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	238	17	injury	injury	NN
cord-003921-8r8z0otz	238	18	in	in	IN
cord-003921-8r8z0otz	238	19	mice	mouse	NNS
cord-003921-8r8z0otz	239	1	Angiogenesis	Angiogenesis	NNP
cord-003921-8r8z0otz	239	2	in	in	IN
cord-003921-8r8z0otz	239	3	wound	wound	NN
cord-003921-8r8z0otz	239	4	repair	repair	NN
cord-003921-8r8z0otz	239	5	:	:	:
cord-003921-8r8z0otz	239	6	angiogenic	angiogenic	JJ
cord-003921-8r8z0otz	239	7	growth	growth	NN
cord-003921-8r8z0otz	239	8	factors	factor	NNS
cord-003921-8r8z0otz	239	9	and	and	CC
cord-003921-8r8z0otz	239	10	the	the	DT
cord-003921-8r8z0otz	239	11	extracellular	extracellular	JJ
cord-003921-8r8z0otz	239	12	matrix	matrix	NN
cord-003921-8r8z0otz	239	13	Fibronectin	Fibronectin	NNP
cord-003921-8r8z0otz	239	14	-	-	HYPH
cord-003921-8r8z0otz	239	15	alpha4beta1	alpha4beta1	NNP
cord-003921-8r8z0otz	239	16	integrin	integrin	NN
cord-003921-8r8z0otz	239	17	interactions	interaction	NNS
cord-003921-8r8z0otz	239	18	regulate	regulate	VBP
cord-003921-8r8z0otz	239	19	metalloproteinase-9	metalloproteinase-9	NNP
cord-003921-8r8z0otz	239	20	expression	expression	NN
cord-003921-8r8z0otz	239	21	in	in	IN
cord-003921-8r8z0otz	239	22	steatotic	steatotic	JJ
cord-003921-8r8z0otz	239	23	liver	liver	NN
cord-003921-8r8z0otz	239	24	ischemia	ischemia	NN
cord-003921-8r8z0otz	239	25	and	and	CC
cord-003921-8r8z0otz	239	26	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	239	27	injury	injury	NN
cord-003921-8r8z0otz	239	28	Metalloproteinase-9	Metalloproteinase-9	NNP
cord-003921-8r8z0otz	239	29	deficiency	deficiency	NN
cord-003921-8r8z0otz	239	30	protects	protect	VBZ
cord-003921-8r8z0otz	239	31	against	against	IN
cord-003921-8r8z0otz	239	32	hepatic	hepatic	JJ
cord-003921-8r8z0otz	239	33	ischemia	ischemia	NN
cord-003921-8r8z0otz	239	34	/	/	SYM
cord-003921-8r8z0otz	239	35	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	239	36	injury	injury	NN
cord-003921-8r8z0otz	239	37	TIMP-1	TIMP-1	NNP
cord-003921-8r8z0otz	239	38	deficiency	deficiency	NN
cord-003921-8r8z0otz	239	39	leads	lead	VBZ
cord-003921-8r8z0otz	239	40	to	to	IN
cord-003921-8r8z0otz	239	41	lethal	lethal	JJ
cord-003921-8r8z0otz	239	42	partial	partial	JJ
cord-003921-8r8z0otz	239	43	hepatic	hepatic	JJ
cord-003921-8r8z0otz	239	44	ischemia	ischemia	NN
cord-003921-8r8z0otz	239	45	and	and	CC
cord-003921-8r8z0otz	239	46	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	239	47	injury	injury	NN
cord-003921-8r8z0otz	239	48	Adeno	Adeno	NNP
cord-003921-8r8z0otz	239	49	-	-	HYPH
cord-003921-8r8z0otz	239	50	associated	associate	VBN
cord-003921-8r8z0otz	239	51	virus	virus	NN
cord-003921-8r8z0otz	239	52	-	-	HYPH
cord-003921-8r8z0otz	239	53	mediated	mediate	VBN
cord-003921-8r8z0otz	239	54	gene	gene	NN
cord-003921-8r8z0otz	239	55	transfer	transfer	NN
cord-003921-8r8z0otz	239	56	of	of	IN
cord-003921-8r8z0otz	239	57	tissue	tissue	NN
cord-003921-8r8z0otz	239	58	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	239	59	of	of	IN
cord-003921-8r8z0otz	239	60	metalloproteinases-1	metalloproteinases-1	NNP
cord-003921-8r8z0otz	239	61	impairs	impair	VBZ
cord-003921-8r8z0otz	239	62	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	239	63	extracellular	extracellular	JJ
cord-003921-8r8z0otz	239	64	trap	trap	NN
cord-003921-8r8z0otz	239	65	formation	formation	NN
cord-003921-8r8z0otz	239	66	and	and	CC
cord-003921-8r8z0otz	239	67	ameliorates	ameliorate	VBZ
cord-003921-8r8z0otz	239	68	hepatic	hepatic	JJ
cord-003921-8r8z0otz	239	69	ischemia	ischemia	NN
cord-003921-8r8z0otz	239	70	and	and	CC
cord-003921-8r8z0otz	239	71	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	239	72	injury	injury	NN
cord-003921-8r8z0otz	239	73	Assessment	Assessment	NNP
cord-003921-8r8z0otz	239	74	of	of	IN
cord-003921-8r8z0otz	239	75	serum	serum	NN
cord-003921-8r8z0otz	239	76	matrix	matrix	NN
cord-003921-8r8z0otz	239	77	metalloproteinases	metalloproteinase	NNS
cord-003921-8r8z0otz	239	78	MMP-2	MMP-2	NNP
cord-003921-8r8z0otz	239	79	and	and	CC
cord-003921-8r8z0otz	239	80	MMP-9	MMP-9	NNP
cord-003921-8r8z0otz	239	81	after	after	IN
cord-003921-8r8z0otz	239	82	human	human	JJ
cord-003921-8r8z0otz	239	83	liver	liver	NN
cord-003921-8r8z0otz	239	84	transplantation	transplantation	NN
cord-003921-8r8z0otz	239	85	:	:	:
cord-003921-8r8z0otz	240	1	increased	increase	VBN
cord-003921-8r8z0otz	240	2	serum	serum	NN
cord-003921-8r8z0otz	240	3	MMP-9	MMP-9	NNP
cord-003921-8r8z0otz	240	4	level	level	NN
cord-003921-8r8z0otz	240	5	in	in	IN
cord-003921-8r8z0otz	240	6	acute	acute	JJ
cord-003921-8r8z0otz	240	7	rejection	rejection	NN
cord-003921-8r8z0otz	240	8	Role	role	NN
cord-003921-8r8z0otz	240	9	of	of	IN
cord-003921-8r8z0otz	240	10	NADPH	NADPH	NNP
cord-003921-8r8z0otz	240	11	oxidase	oxidase	NN
cord-003921-8r8z0otz	240	12	in	in	IN
cord-003921-8r8z0otz	240	13	endothelial	endothelial	JJ
cord-003921-8r8z0otz	240	14	ischemia	ischemia	NN
cord-003921-8r8z0otz	240	15	/	/	SYM
cord-003921-8r8z0otz	240	16	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	240	17	injury	injury	NN
cord-003921-8r8z0otz	240	18	in	in	IN
cord-003921-8r8z0otz	240	19	humans	human	NNS
cord-003921-8r8z0otz	240	20	Ischemia	ischemia	NN
cord-003921-8r8z0otz	240	21	-	-	HYPH
cord-003921-8r8z0otz	240	22	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	240	23	injury	injury	NN
cord-003921-8r8z0otz	240	24	in	in	IN
cord-003921-8r8z0otz	240	25	fatty	fatty	JJ
cord-003921-8r8z0otz	240	26	liver	liver	NN
cord-003921-8r8z0otz	240	27	is	be	VBZ
cord-003921-8r8z0otz	240	28	mediated	mediate	VBN
cord-003921-8r8z0otz	240	29	by	by	IN
cord-003921-8r8z0otz	240	30	activated	activate	VBN
cord-003921-8r8z0otz	240	31	NADPH	NADPH	NNP
cord-003921-8r8z0otz	240	32	oxidase	oxidase	NN
cord-003921-8r8z0otz	240	33	2	2	CD
cord-003921-8r8z0otz	240	34	in	in	IN
cord-003921-8r8z0otz	240	35	rats	rat	NNS
cord-003921-8r8z0otz	240	36	Sivelestat	Sivelestat	NNP
cord-003921-8r8z0otz	240	37	sodium	sodium	NN
cord-003921-8r8z0otz	240	38	hydrate	hydrate	VBP
cord-003921-8r8z0otz	240	39	inhibits	inhibit	VBZ
cord-003921-8r8z0otz	240	40	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	240	41	migration	migration	NN
cord-003921-8r8z0otz	240	42	to	to	IN
cord-003921-8r8z0otz	240	43	the	the	DT
cord-003921-8r8z0otz	240	44	vessel	vessel	NN
cord-003921-8r8z0otz	240	45	wall	wall	NN
cord-003921-8r8z0otz	240	46	and	and	CC
cord-003921-8r8z0otz	240	47	suppresses	suppress	VBZ
cord-003921-8r8z0otz	240	48	hepatic	hepatic	JJ
cord-003921-8r8z0otz	240	49	ischemia	ischemia	NN
cord-003921-8r8z0otz	240	50	-	-	HYPH
cord-003921-8r8z0otz	240	51	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	240	52	injury	injury	NN
cord-003921-8r8z0otz	241	1	The	the	DT
cord-003921-8r8z0otz	241	2	inhibition	inhibition	NN
cord-003921-8r8z0otz	241	3	of	of	IN
cord-003921-8r8z0otz	241	4	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	241	5	elastase	elastase	NN
cord-003921-8r8z0otz	241	6	ameliorates	ameliorate	VBZ
cord-003921-8r8z0otz	241	7	mouse	mouse	NN
cord-003921-8r8z0otz	241	8	liver	liver	NN
cord-003921-8r8z0otz	241	9	damage	damage	NN
cord-003921-8r8z0otz	241	10	due	due	JJ
cord-003921-8r8z0otz	241	11	to	to	IN
cord-003921-8r8z0otz	241	12	ischemia	ischemia	NN
cord-003921-8r8z0otz	241	13	and	and	CC
cord-003921-8r8z0otz	241	14	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	242	1	The	the	DT
cord-003921-8r8z0otz	242	2	effect	effect	NN
cord-003921-8r8z0otz	242	3	of	of	IN
cord-003921-8r8z0otz	242	4	the	the	DT
cord-003921-8r8z0otz	242	5	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	242	6	elastase	elastase	NN
cord-003921-8r8z0otz	242	7	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	242	8	sivelestat	sivelestat	NN
cord-003921-8r8z0otz	242	9	on	on	IN
cord-003921-8r8z0otz	242	10	early	early	JJ
cord-003921-8r8z0otz	242	11	injury	injury	NN
cord-003921-8r8z0otz	242	12	after	after	IN
cord-003921-8r8z0otz	242	13	liver	liver	NN
cord-003921-8r8z0otz	242	14	resection	resection	NN
cord-003921-8r8z0otz	242	15	Myeloperoxidase	Myeloperoxidase	NNP
cord-003921-8r8z0otz	242	16	:	:	:
cord-003921-8r8z0otz	242	17	friend	friend	NN
cord-003921-8r8z0otz	242	18	and	and	CC
cord-003921-8r8z0otz	242	19	foe	foe	NN
cord-003921-8r8z0otz	243	1	This	this	DT
cord-003921-8r8z0otz	243	2	study	study	NN
cord-003921-8r8z0otz	243	3	demonstrates	demonstrate	VBZ
cord-003921-8r8z0otz	243	4	the	the	DT
cord-003921-8r8z0otz	243	5	unexpected	unexpected	JJ
cord-003921-8r8z0otz	243	6	requirement	requirement	NN
cord-003921-8r8z0otz	243	7	for	for	IN
cord-003921-8r8z0otz	243	8	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	243	9	and	and	CC
cord-003921-8r8z0otz	243	10	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	243	11	-	-	HYPH
cord-003921-8r8z0otz	243	12	derived	derive	VBN
cord-003921-8r8z0otz	243	13	MPO	MPO	NNP
cord-003921-8r8z0otz	243	14	in	in	IN
cord-003921-8r8z0otz	243	15	hepatoprotection	hepatoprotection	NN
cord-003921-8r8z0otz	243	16	against	against	IN
cord-003921-8r8z0otz	243	17	endotoxin	endotoxin	NN
cord-003921-8r8z0otz	243	18	-	-	HYPH
cord-003921-8r8z0otz	243	19	induced	induce	VBN
cord-003921-8r8z0otz	243	20	liver	liver	NN
cord-003921-8r8z0otz	243	21	injury	injury	NN
cord-003921-8r8z0otz	243	22	and	and	CC
cord-003921-8r8z0otz	243	23	highlights	highlight	VBZ
cord-003921-8r8z0otz	243	24	a	a	DT
cord-003921-8r8z0otz	243	25	novel	novel	JJ
cord-003921-8r8z0otz	243	26	immunoregulatory	immunoregulatory	NNP
cord-003921-8r8z0otz	243	27	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	243	28	function	function	NN
cord-003921-8r8z0otz	243	29	Effect	effect	NN
cord-003921-8r8z0otz	243	30	of	of	IN
cord-003921-8r8z0otz	243	31	the	the	DT
cord-003921-8r8z0otz	243	32	myeloperoxidase	myeloperoxidase	NN
cord-003921-8r8z0otz	243	33	inhibitor	inhibitor	NN
cord-003921-8r8z0otz	243	34	AZD3241	AZD3241	NNP
cord-003921-8r8z0otz	243	35	on	on	IN
cord-003921-8r8z0otz	243	36	microglia	microglia	NNP
cord-003921-8r8z0otz	243	37	:	:	:
cord-003921-8r8z0otz	244	1	a	a	DT
cord-003921-8r8z0otz	244	2	PET	PET	NNP
cord-003921-8r8z0otz	244	3	study	study	NN
cord-003921-8r8z0otz	244	4	in	in	IN
cord-003921-8r8z0otz	244	5	Parkinson	Parkinson	NNP
cord-003921-8r8z0otz	244	6	's	's	POS
cord-003921-8r8z0otz	244	7	disease	disease	NN
cord-003921-8r8z0otz	244	8	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	244	9	extracellular	extracellular	JJ
cord-003921-8r8z0otz	244	10	traps	trap	NNS
cord-003921-8r8z0otz	244	11	:	:	:
cord-003921-8r8z0otz	244	12	double	double	RB
cord-003921-8r8z0otz	244	13	-	-	HYPH
cord-003921-8r8z0otz	244	14	edged	edge	VBN
cord-003921-8r8z0otz	244	15	swords	sword	NNS
cord-003921-8r8z0otz	244	16	of	of	IN
cord-003921-8r8z0otz	244	17	innate	innate	JJ
cord-003921-8r8z0otz	244	18	immunity	immunity	NN
cord-003921-8r8z0otz	245	1	An	an	DT
cord-003921-8r8z0otz	245	2	emerging	emerge	VBG
cord-003921-8r8z0otz	245	3	role	role	NN
cord-003921-8r8z0otz	245	4	for	for	IN
cord-003921-8r8z0otz	245	5	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	245	6	extracellular	extracellular	JJ
cord-003921-8r8z0otz	245	7	traps	trap	NNS
cord-003921-8r8z0otz	245	8	in	in	IN
cord-003921-8r8z0otz	245	9	noninfectious	noninfectious	JJ
cord-003921-8r8z0otz	245	10	disease	disease	NN
cord-003921-8r8z0otz	245	11	Histones	Histones	NNPS
cord-003921-8r8z0otz	245	12	and	and	CC
cord-003921-8r8z0otz	245	13	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	245	14	extracellular	extracellular	JJ
cord-003921-8r8z0otz	245	15	traps	trap	NNS
cord-003921-8r8z0otz	245	16	enhance	enhance	VBP
cord-003921-8r8z0otz	245	17	tubular	tubular	JJ
cord-003921-8r8z0otz	245	18	necrosis	necrosis	NN
cord-003921-8r8z0otz	245	19	and	and	CC
cord-003921-8r8z0otz	245	20	remote	remote	JJ
cord-003921-8r8z0otz	245	21	organ	organ	NN
cord-003921-8r8z0otz	245	22	injury	injury	NN
cord-003921-8r8z0otz	245	23	in	in	IN
cord-003921-8r8z0otz	245	24	ischemic	ischemic	JJ
cord-003921-8r8z0otz	245	25	AKI	AKI	NNP
cord-003921-8r8z0otz	245	26	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	245	27	extracellular	extracellular	JJ
cord-003921-8r8z0otz	245	28	traps	trap	NNS
cord-003921-8r8z0otz	245	29	are	be	VBP
cord-003921-8r8z0otz	245	30	pathogenic	pathogenic	JJ
cord-003921-8r8z0otz	245	31	in	in	IN
cord-003921-8r8z0otz	245	32	primary	primary	JJ
cord-003921-8r8z0otz	245	33	graft	graft	NN
cord-003921-8r8z0otz	245	34	dysfunction	dysfunction	NN
cord-003921-8r8z0otz	245	35	after	after	IN
cord-003921-8r8z0otz	245	36	lung	lung	NN
cord-003921-8r8z0otz	245	37	transplantation	transplantation	NN
cord-003921-8r8z0otz	245	38	Damage	damage	NN
cord-003921-8r8z0otz	245	39	-	-	HYPH
cord-003921-8r8z0otz	245	40	associated	associate	VBN
cord-003921-8r8z0otz	245	41	molecular	molecular	JJ
cord-003921-8r8z0otz	245	42	pattern	pattern	NN
cord-003921-8r8z0otz	245	43	-	-	HYPH
cord-003921-8r8z0otz	245	44	activated	activate	VBN
cord-003921-8r8z0otz	245	45	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	245	46	extracellular	extracellular	JJ
cord-003921-8r8z0otz	245	47	trap	trap	NN
cord-003921-8r8z0otz	245	48	exacerbates	exacerbate	VBZ
cord-003921-8r8z0otz	245	49	sterile	sterile	JJ
cord-003921-8r8z0otz	245	50	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	245	51	liver	liver	NN
cord-003921-8r8z0otz	245	52	injury	injury	NN
cord-003921-8r8z0otz	246	1	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	246	2	extracellular	extracellular	JJ
cord-003921-8r8z0otz	246	3	traps	trap	NNS
cord-003921-8r8z0otz	246	4	in	in	IN
cord-003921-8r8z0otz	246	5	ischemia	ischemia	NN
cord-003921-8r8z0otz	246	6	-	-	HYPH
cord-003921-8r8z0otz	246	7	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	246	8	injury	injury	NN
cord-003921-8r8z0otz	246	9	-	-	HYPH
cord-003921-8r8z0otz	246	10	induced	induce	VBN
cord-003921-8r8z0otz	246	11	myocardial	myocardial	JJ
cord-003921-8r8z0otz	246	12	no	no	DT
cord-003921-8r8z0otz	246	13	-	-	HYPH
cord-003921-8r8z0otz	246	14	reflow	reflow	NN
cord-003921-8r8z0otz	246	15	:	:	:
cord-003921-8r8z0otz	246	16	therapeutic	therapeutic	JJ
cord-003921-8r8z0otz	246	17	potential	potential	NN
cord-003921-8r8z0otz	246	18	of	of	IN
cord-003921-8r8z0otz	246	19	DNase	DNase	NNP
cord-003921-8r8z0otz	246	20	-	-	HYPH
cord-003921-8r8z0otz	246	21	based	base	VBN
cord-003921-8r8z0otz	246	22	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	246	23	strategy	strategy	NN
cord-003921-8r8z0otz	246	24	Human	human	JJ
cord-003921-8r8z0otz	246	25	eosinophil	eosinophil	JJ
cord-003921-8r8z0otz	246	26	granulocytes	granulocyte	NNS
cord-003921-8r8z0otz	246	27	do	do	VBP
cord-003921-8r8z0otz	246	28	not	not	RB
cord-003921-8r8z0otz	246	29	express	express	VB
cord-003921-8r8z0otz	246	30	the	the	DT
cord-003921-8r8z0otz	246	31	enzyme	enzyme	NN
cord-003921-8r8z0otz	247	1	arginase	arginase	NNP
cord-003921-8r8z0otz	248	1	Arginase	Arginase	NNP
cord-003921-8r8z0otz	249	1	I	-PRON-	PRP
cord-003921-8r8z0otz	249	2	is	be	VBZ
cord-003921-8r8z0otz	249	3	constitutively	constitutively	RB
cord-003921-8r8z0otz	249	4	expressed	express	VBN
cord-003921-8r8z0otz	249	5	in	in	IN
cord-003921-8r8z0otz	249	6	human	human	JJ
cord-003921-8r8z0otz	249	7	granulocytes	granulocyte	NNS
cord-003921-8r8z0otz	249	8	and	and	CC
cord-003921-8r8z0otz	249	9	participates	participate	VBZ
cord-003921-8r8z0otz	249	10	in	in	IN
cord-003921-8r8z0otz	249	11	fungicidal	fungicidal	JJ
cord-003921-8r8z0otz	249	12	activity	activity	NN
cord-003921-8r8z0otz	250	1	Mature	mature	JJ
cord-003921-8r8z0otz	250	2	cystic	cystic	JJ
cord-003921-8r8z0otz	250	3	fibrosis	fibrosis	NN
cord-003921-8r8z0otz	250	4	airway	airway	NN
cord-003921-8r8z0otz	250	5	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	250	6	suppress	suppress	VBP
cord-003921-8r8z0otz	250	7	T	T	NNP
cord-003921-8r8z0otz	250	8	cell	cell	NN
cord-003921-8r8z0otz	250	9	function	function	NN
cord-003921-8r8z0otz	250	10	:	:	:
cord-003921-8r8z0otz	250	11	evidence	evidence	NN
cord-003921-8r8z0otz	250	12	for	for	IN
cord-003921-8r8z0otz	250	13	a	a	DT
cord-003921-8r8z0otz	250	14	role	role	NN
cord-003921-8r8z0otz	250	15	of	of	IN
cord-003921-8r8z0otz	250	16	arginase	arginase	NN
cord-003921-8r8z0otz	250	17	1	1	CD
cord-003921-8r8z0otz	250	18	but	but	CC
cord-003921-8r8z0otz	250	19	not	not	RB
cord-003921-8r8z0otz	250	20	programmed	program	VBN
cord-003921-8r8z0otz	250	21	death	death	NN
cord-003921-8r8z0otz	250	22	-	-	HYPH
cord-003921-8r8z0otz	250	23	ligand	ligand	NN
cord-003921-8r8z0otz	250	24	1	1	CD
cord-003921-8r8z0otz	251	1	l	l	LS
cord-003921-8r8z0otz	251	2	-	-	HYPH
cord-003921-8r8z0otz	251	3	Arginine	Arginine	NNP
cord-003921-8r8z0otz	251	4	depletion	depletion	NN
cord-003921-8r8z0otz	251	5	blunts	blunt	VBZ
cord-003921-8r8z0otz	251	6	antitumor	antitumor	JJ
cord-003921-8r8z0otz	251	7	T	t	NN
cord-003921-8r8z0otz	251	8	-	-	HYPH
cord-003921-8r8z0otz	251	9	cell	cell	NN
cord-003921-8r8z0otz	251	10	responses	response	NNS
cord-003921-8r8z0otz	251	11	by	by	IN
cord-003921-8r8z0otz	251	12	inducing	induce	VBG
cord-003921-8r8z0otz	251	13	myeloid	myeloid	NN
cord-003921-8r8z0otz	251	14	-	-	HYPH
cord-003921-8r8z0otz	251	15	derived	derive	VBN
cord-003921-8r8z0otz	251	16	suppressor	suppressor	NN
cord-003921-8r8z0otz	251	17	cells	cell	NNS
cord-003921-8r8z0otz	251	18	Cleavage	cleavage	NN
cord-003921-8r8z0otz	251	19	of	of	IN
cord-003921-8r8z0otz	251	20	lymphocyte	lymphocyte	NN
cord-003921-8r8z0otz	251	21	surface	surface	NN
cord-003921-8r8z0otz	251	22	antigens	antigen	NNS
cord-003921-8r8z0otz	251	23	CD2	CD2	NNP
cord-003921-8r8z0otz	251	24	,	,	,
cord-003921-8r8z0otz	251	25	CD4	CD4	NNP
cord-003921-8r8z0otz	251	26	,	,	,
cord-003921-8r8z0otz	251	27	and	and	CC
cord-003921-8r8z0otz	251	28	CD8	CD8	NNP
cord-003921-8r8z0otz	251	29	by	by	IN
cord-003921-8r8z0otz	251	30	polymorphonuclear	polymorphonuclear	NNP
cord-003921-8r8z0otz	251	31	leukocyte	leukocyte	NN
cord-003921-8r8z0otz	251	32	elastase	elastase	NN
cord-003921-8r8z0otz	251	33	and	and	CC
cord-003921-8r8z0otz	251	34	cathepsin	cathepsin	NN
cord-003921-8r8z0otz	251	35	G	g	NN
cord-003921-8r8z0otz	251	36	in	in	IN
cord-003921-8r8z0otz	251	37	patients	patient	NNS
cord-003921-8r8z0otz	251	38	with	with	IN
cord-003921-8r8z0otz	251	39	cystic	cystic	JJ
cord-003921-8r8z0otz	251	40	fibrosis	fibrosis	NN
cord-003921-8r8z0otz	252	1	Oxidation	oxidation	NN
cord-003921-8r8z0otz	252	2	of	of	IN
cord-003921-8r8z0otz	252	3	cofilin	cofilin	NN
cord-003921-8r8z0otz	252	4	mediates	mediate	VBZ
cord-003921-8r8z0otz	252	5	T	T	NNP
cord-003921-8r8z0otz	252	6	cell	cell	NN
cord-003921-8r8z0otz	252	7	hyporesponsiveness	hyporesponsiveness	NN
cord-003921-8r8z0otz	252	8	under	under	IN
cord-003921-8r8z0otz	252	9	oxidative	oxidative	JJ
cord-003921-8r8z0otz	252	10	stress	stress	NN
cord-003921-8r8z0otz	252	11	conditions	condition	NNS
cord-003921-8r8z0otz	253	1	Naturally	naturally	RB
cord-003921-8r8z0otz	253	2	occurring	occur	VBG
cord-003921-8r8z0otz	253	3	regulatory	regulatory	JJ
cord-003921-8r8z0otz	253	4	T	t	NN
cord-003921-8r8z0otz	253	5	cells	cell	NNS
cord-003921-8r8z0otz	253	6	show	show	VBP
cord-003921-8r8z0otz	253	7	reduced	reduced	JJ
cord-003921-8r8z0otz	253	8	sensitivity	sensitivity	NN
cord-003921-8r8z0otz	253	9	toward	toward	IN
cord-003921-8r8z0otz	253	10	oxidative	oxidative	JJ
cord-003921-8r8z0otz	253	11	stress	stress	NN
cord-003921-8r8z0otz	253	12	-	-	HYPH
cord-003921-8r8z0otz	253	13	induced	induce	VBN
cord-003921-8r8z0otz	253	14	cell	cell	NN
cord-003921-8r8z0otz	253	15	death	death	NN
cord-003921-8r8z0otz	253	16	Neutrophils	Neutrophils	NNP
cord-003921-8r8z0otz	253	17	in	in	IN
cord-003921-8r8z0otz	253	18	homeostasis	homeostasis	NN
cord-003921-8r8z0otz	253	19	,	,	,
cord-003921-8r8z0otz	253	20	immunity	immunity	NN
cord-003921-8r8z0otz	253	21	,	,	,
cord-003921-8r8z0otz	253	22	and	and	CC
cord-003921-8r8z0otz	253	23	cancer	cancer	NN
cord-003921-8r8z0otz	253	24	Neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	253	25	can	can	MD
cord-003921-8r8z0otz	253	26	disarm	disarm	VB
cord-003921-8r8z0otz	253	27	NK	NK	NNP
cord-003921-8r8z0otz	253	28	cell	cell	NN
cord-003921-8r8z0otz	253	29	response	response	NN
cord-003921-8r8z0otz	253	30	through	through	IN
cord-003921-8r8z0otz	253	31	cleavage	cleavage	NN
cord-003921-8r8z0otz	253	32	of	of	IN
cord-003921-8r8z0otz	253	33	NKp46	nkp46	JJ
cord-003921-8r8z0otz	253	34	Specific	specific	JJ
cord-003921-8r8z0otz	253	35	lipid	lipid	NN
cord-003921-8r8z0otz	253	36	mediator	mediator	NN
cord-003921-8r8z0otz	253	37	signatures	signature	NNS
cord-003921-8r8z0otz	253	38	of	of	IN
cord-003921-8r8z0otz	253	39	human	human	JJ
cord-003921-8r8z0otz	253	40	phagocytes	phagocyte	NNS
cord-003921-8r8z0otz	253	41	:	:	:
cord-003921-8r8z0otz	253	42	microparticles	microparticle	NNS
cord-003921-8r8z0otz	253	43	stimulate	stimulate	VBP
cord-003921-8r8z0otz	253	44	macrophage	macrophage	NN
cord-003921-8r8z0otz	253	45	efferocytosis	efferocytosis	NN
cord-003921-8r8z0otz	253	46	and	and	CC
cord-003921-8r8z0otz	253	47	pro	pro	JJ
cord-003921-8r8z0otz	253	48	-	-	JJ
cord-003921-8r8z0otz	253	49	resolving	resolve	VBG
cord-003921-8r8z0otz	253	50	mediators	mediator	NNS
cord-003921-8r8z0otz	253	51	Endogenous	endogenous	JJ
cord-003921-8r8z0otz	253	52	lipid	lipid	NN
cord-003921-8r8z0otz	253	53	-	-	HYPH
cord-003921-8r8z0otz	253	54	and	and	CC
cord-003921-8r8z0otz	253	55	peptide	peptide	NN
cord-003921-8r8z0otz	253	56	-	-	HYPH
cord-003921-8r8z0otz	253	57	derived	derive	VBN
cord-003921-8r8z0otz	253	58	anti	anti	JJ
cord-003921-8r8z0otz	253	59	-	-	JJ
cord-003921-8r8z0otz	253	60	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	253	61	pathways	pathway	NNS
cord-003921-8r8z0otz	253	62	generated	generate	VBN
cord-003921-8r8z0otz	253	63	with	with	IN
cord-003921-8r8z0otz	253	64	glucocorticoid	glucocorticoid	NN
cord-003921-8r8z0otz	253	65	and	and	CC
cord-003921-8r8z0otz	253	66	aspirin	aspirin	NN
cord-003921-8r8z0otz	253	67	treatment	treatment	NN
cord-003921-8r8z0otz	253	68	activate	activate	VBP
cord-003921-8r8z0otz	253	69	the	the	DT
cord-003921-8r8z0otz	253	70	lipoxin	lipoxin	NNP
cord-003921-8r8z0otz	253	71	A4	A4	NNP
cord-003921-8r8z0otz	253	72	receptor	receptor	NN
cord-003921-8r8z0otz	253	73	Annexin	Annexin	NNP
cord-003921-8r8z0otz	253	74	1	1	CD
cord-003921-8r8z0otz	253	75	mediates	mediate	VBZ
cord-003921-8r8z0otz	253	76	the	the	DT
cord-003921-8r8z0otz	253	77	rapid	rapid	JJ
cord-003921-8r8z0otz	253	78	anti	anti	JJ
cord-003921-8r8z0otz	253	79	-	-	JJ
cord-003921-8r8z0otz	253	80	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	253	81	effects	effect	NNS
cord-003921-8r8z0otz	253	82	of	of	IN
cord-003921-8r8z0otz	253	83	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	253	84	-	-	HYPH
cord-003921-8r8z0otz	253	85	derived	derive	VBN
cord-003921-8r8z0otz	253	86	microparticles	microparticle	NNS
cord-003921-8r8z0otz	253	87	Annexin-1	Annexin-1	NNP
cord-003921-8r8z0otz	253	88	and	and	CC
cord-003921-8r8z0otz	253	89	peptide	peptide	NN
cord-003921-8r8z0otz	253	90	derivatives	derivative	NNS
cord-003921-8r8z0otz	253	91	are	be	VBP
cord-003921-8r8z0otz	253	92	released	release	VBN
cord-003921-8r8z0otz	253	93	by	by	IN
cord-003921-8r8z0otz	253	94	apoptotic	apoptotic	JJ
cord-003921-8r8z0otz	253	95	cells	cell	NNS
cord-003921-8r8z0otz	253	96	and	and	CC
cord-003921-8r8z0otz	253	97	stimulate	stimulate	VBP
cord-003921-8r8z0otz	253	98	phagocytosis	phagocytosis	NN
cord-003921-8r8z0otz	253	99	of	of	IN
cord-003921-8r8z0otz	253	100	apoptotic	apoptotic	JJ
cord-003921-8r8z0otz	253	101	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	253	102	by	by	IN
cord-003921-8r8z0otz	253	103	macrophages	macrophage	NNS
cord-003921-8r8z0otz	253	104	Monocyte	Monocyte	NNP
cord-003921-8r8z0otz	253	105	and	and	CC
cord-003921-8r8z0otz	253	106	macrophage	macrophage	NN
cord-003921-8r8z0otz	253	107	heterogeneity	heterogeneity	NN
cord-003921-8r8z0otz	253	108	Polarization	polarization	NN
cord-003921-8r8z0otz	253	109	of	of	IN
cord-003921-8r8z0otz	253	110	tumor	tumor	NN
cord-003921-8r8z0otz	253	111	-	-	HYPH
cord-003921-8r8z0otz	253	112	associated	associate	VBN
cord-003921-8r8z0otz	253	113	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	253	114	phenotype	phenotype	NN
cord-003921-8r8z0otz	253	115	by	by	IN
cord-003921-8r8z0otz	253	116	TGFbeta	tgfbeta	NN
cord-003921-8r8z0otz	253	117	:	:	:
cord-003921-8r8z0otz	253	118	"	"	``
cord-003921-8r8z0otz	253	119	N1	N1	NNP
cord-003921-8r8z0otz	253	120	"	"	''
cord-003921-8r8z0otz	253	121	versus	versus	IN
cord-003921-8r8z0otz	253	122	"	"	``
cord-003921-8r8z0otz	253	123	N2	N2	NNP
cord-003921-8r8z0otz	253	124	"	"	''
cord-003921-8r8z0otz	253	125	TAN	tan	NN
cord-003921-8r8z0otz	254	1	On	on	IN
cord-003921-8r8z0otz	254	2	the	the	DT
cord-003921-8r8z0otz	254	3	dual	dual	JJ
cord-003921-8r8z0otz	254	4	roles	role	NNS
cord-003921-8r8z0otz	254	5	and	and	CC
cord-003921-8r8z0otz	254	6	polarized	polarized	JJ
cord-003921-8r8z0otz	254	7	phenotypes	phenotype	NNS
cord-003921-8r8z0otz	254	8	of	of	IN
cord-003921-8r8z0otz	254	9	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	254	10	in	in	IN
cord-003921-8r8z0otz	254	11	tumor	tumor	NN
cord-003921-8r8z0otz	254	12	development	development	NN
cord-003921-8r8z0otz	254	13	and	and	CC
cord-003921-8r8z0otz	254	14	progression	progression	NN
cord-003921-8r8z0otz	255	1	An	an	DT
cord-003921-8r8z0otz	255	2	overview	overview	NN
cord-003921-8r8z0otz	255	3	of	of	IN
cord-003921-8r8z0otz	255	4	the	the	DT
cord-003921-8r8z0otz	255	5	role	role	NN
cord-003921-8r8z0otz	255	6	of	of	IN
cord-003921-8r8z0otz	255	7	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	255	8	in	in	IN
cord-003921-8r8z0otz	255	9	innate	innate	JJ
cord-003921-8r8z0otz	255	10	immunity	immunity	NN
cord-003921-8r8z0otz	255	11	,	,	,
cord-003921-8r8z0otz	255	12	inflammation	inflammation	NN
cord-003921-8r8z0otz	255	13	and	and	CC
cord-003921-8r8z0otz	255	14	hostbiomaterial	hostbiomaterial	JJ
cord-003921-8r8z0otz	255	15	integration	integration	NN
cord-003921-8r8z0otz	255	16	Neutrophils	Neutrophils	NNP
cord-003921-8r8z0otz	255	17	responsive	responsive	JJ
cord-003921-8r8z0otz	255	18	to	to	IN
cord-003921-8r8z0otz	255	19	endogenous	endogenous	JJ
cord-003921-8r8z0otz	255	20	IFN	IFN	NNP
cord-003921-8r8z0otz	255	21	-	-	HYPH
cord-003921-8r8z0otz	255	22	beta	beta	NN
cord-003921-8r8z0otz	255	23	regulate	regulate	VB
cord-003921-8r8z0otz	255	24	tumor	tumor	NN
cord-003921-8r8z0otz	255	25	angiogenesis	angiogenesis	NN
cord-003921-8r8z0otz	255	26	and	and	CC
cord-003921-8r8z0otz	255	27	growth	growth	NN
cord-003921-8r8z0otz	255	28	in	in	IN
cord-003921-8r8z0otz	255	29	a	a	DT
cord-003921-8r8z0otz	255	30	mouse	mouse	NN
cord-003921-8r8z0otz	255	31	tumor	tumor	NN
cord-003921-8r8z0otz	255	32	model	model	NN
cord-003921-8r8z0otz	255	33	Temporal	temporal	JJ
cord-003921-8r8z0otz	255	34	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	255	35	polarization	polarization	NN
cord-003921-8r8z0otz	255	36	following	follow	VBG
cord-003921-8r8z0otz	255	37	myocardial	myocardial	JJ
cord-003921-8r8z0otz	255	38	infarction	infarction	NN
cord-003921-8r8z0otz	255	39	N2	N2	NNP
cord-003921-8r8z0otz	255	40	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	255	41	,	,	,
cord-003921-8r8z0otz	255	42	novel	novel	JJ
cord-003921-8r8z0otz	255	43	players	player	NNS
cord-003921-8r8z0otz	255	44	in	in	IN
cord-003921-8r8z0otz	255	45	brain	brain	NN
cord-003921-8r8z0otz	255	46	inflammation	inflammation	NN
cord-003921-8r8z0otz	255	47	after	after	IN
cord-003921-8r8z0otz	255	48	stroke	stroke	NN
cord-003921-8r8z0otz	255	49	:	:	:
cord-003921-8r8z0otz	255	50	modulation	modulation	NN
cord-003921-8r8z0otz	255	51	by	by	IN
cord-003921-8r8z0otz	255	52	the	the	DT
cord-003921-8r8z0otz	255	53	PPARgamma	PPARgamma	NNP
cord-003921-8r8z0otz	255	54	agonist	agonist	NN
cord-003921-8r8z0otz	255	55	rosiglitazone	rosiglitazone	NN
cord-003921-8r8z0otz	255	56	Macrophage	Macrophage	NNP
cord-003921-8r8z0otz	255	57	plasticity	plasticity	NN
cord-003921-8r8z0otz	255	58	,	,	,
cord-003921-8r8z0otz	255	59	polarization	polarization	NN
cord-003921-8r8z0otz	255	60	,	,	,
cord-003921-8r8z0otz	255	61	and	and	CC
cord-003921-8r8z0otz	255	62	function	function	VB
cord-003921-8r8z0otz	255	63	in	in	IN
cord-003921-8r8z0otz	255	64	health	health	NN
cord-003921-8r8z0otz	255	65	and	and	CC
cord-003921-8r8z0otz	255	66	disease	disease	NN
cord-003921-8r8z0otz	255	67	Profound	profound	JJ
cord-003921-8r8z0otz	255	68	functional	functional	JJ
cord-003921-8r8z0otz	255	69	and	and	CC
cord-003921-8r8z0otz	255	70	signaling	signal	VBG
cord-003921-8r8z0otz	255	71	changes	change	NNS
cord-003921-8r8z0otz	255	72	in	in	IN
cord-003921-8r8z0otz	255	73	viable	viable	JJ
cord-003921-8r8z0otz	255	74	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	255	75	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	255	76	homing	homing	NN
cord-003921-8r8z0otz	255	77	to	to	IN
cord-003921-8r8z0otz	256	1	cystic	cystic	NNP
cord-003921-8r8z0otz	256	2	fibrosis	fibrosis	NNP
cord-003921-8r8z0otz	256	3	airways	airways	NNP
cord-003921-8r8z0otz	256	4	A	a	DT
cord-003921-8r8z0otz	256	5	subset	subset	NN
cord-003921-8r8z0otz	256	6	of	of	IN
cord-003921-8r8z0otz	256	7	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	256	8	in	in	IN
cord-003921-8r8z0otz	256	9	human	human	JJ
cord-003921-8r8z0otz	256	10	systemic	systemic	JJ
cord-003921-8r8z0otz	256	11	inflammation	inflammation	NN
cord-003921-8r8z0otz	256	12	inhibits	inhibit	VBZ
cord-003921-8r8z0otz	256	13	T	t	NN
cord-003921-8r8z0otz	256	14	cell	cell	NN
cord-003921-8r8z0otz	256	15	responses	response	NNS
cord-003921-8r8z0otz	256	16	through	through	IN
cord-003921-8r8z0otz	256	17	Mac-1	Mac-1	NNP
cord-003921-8r8z0otz	256	18	Neutrophils	Neutrophils	NNP
cord-003921-8r8z0otz	256	19	in	in	IN
cord-003921-8r8z0otz	256	20	tissue	tissue	NN
cord-003921-8r8z0otz	256	21	injury	injury	NN
cord-003921-8r8z0otz	256	22	and	and	CC
cord-003921-8r8z0otz	256	23	repair	repair	NN
cord-003921-8r8z0otz	256	24	Immunodeficiency	immunodeficiency	NN
cord-003921-8r8z0otz	256	25	diseases	disease	NNS
cord-003921-8r8z0otz	256	26	caused	cause	VBN
cord-003921-8r8z0otz	256	27	by	by	IN
cord-003921-8r8z0otz	256	28	defects	defect	NNS
cord-003921-8r8z0otz	256	29	in	in	IN
cord-003921-8r8z0otz	256	30	phagocytes	phagocyte	NNS
cord-003921-8r8z0otz	256	31	Visualizing	visualize	VBG
cord-003921-8r8z0otz	256	32	the	the	DT
cord-003921-8r8z0otz	256	33	function	function	NN
cord-003921-8r8z0otz	256	34	and	and	CC
cord-003921-8r8z0otz	256	35	fate	fate	NN
cord-003921-8r8z0otz	256	36	of	of	IN
cord-003921-8r8z0otz	256	37	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	256	38	in	in	IN
cord-003921-8r8z0otz	256	39	sterile	sterile	JJ
cord-003921-8r8z0otz	256	40	injury	injury	NN
cord-003921-8r8z0otz	256	41	and	and	CC
cord-003921-8r8z0otz	256	42	repair	repair	NN
cord-003921-8r8z0otz	256	43	Resolution	resolution	NN
cord-003921-8r8z0otz	256	44	of	of	IN
cord-003921-8r8z0otz	256	45	inflammation	inflammation	NN
cord-003921-8r8z0otz	256	46	:	:	:
cord-003921-8r8z0otz	256	47	an	an	DT
cord-003921-8r8z0otz	256	48	integrated	integrated	JJ
cord-003921-8r8z0otz	256	49	view	view	NN
cord-003921-8r8z0otz	256	50	Human	human	JJ
cord-003921-8r8z0otz	256	51	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	256	52	uniquely	uniquely	RB
cord-003921-8r8z0otz	256	53	release	release	VBP
cord-003921-8r8z0otz	256	54	TIMP	TIMP	NNP
cord-003921-8r8z0otz	256	55	-	-	HYPH
cord-003921-8r8z0otz	256	56	free	free	JJ
cord-003921-8r8z0otz	256	57	MMP-9	MMP-9	NNP
cord-003921-8r8z0otz	256	58	to	to	TO
cord-003921-8r8z0otz	256	59	provide	provide	VB
cord-003921-8r8z0otz	256	60	a	a	DT
cord-003921-8r8z0otz	256	61	potent	potent	JJ
cord-003921-8r8z0otz	256	62	catalytic	catalytic	JJ
cord-003921-8r8z0otz	256	63	stimulator	stimulator	NN
cord-003921-8r8z0otz	256	64	of	of	IN
cord-003921-8r8z0otz	256	65	angiogenesis	angiogenesis	NN
cord-003921-8r8z0otz	257	1	VEGF	VEGF	NNP
cord-003921-8r8z0otz	257	2	-	-	HYPH
cord-003921-8r8z0otz	257	3	A	A	NNP
cord-003921-8r8z0otz	257	4	recruits	recruit	VBZ
cord-003921-8r8z0otz	257	5	a	a	DT
cord-003921-8r8z0otz	257	6	proangiogenic	proangiogenic	JJ
cord-003921-8r8z0otz	257	7	MMP-9-delivering	mmp-9-delivering	NN
cord-003921-8r8z0otz	257	8	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	257	9	subset	subset	VBN
cord-003921-8r8z0otz	257	10	that	that	WDT
cord-003921-8r8z0otz	257	11	induces	induce	VBZ
cord-003921-8r8z0otz	257	12	angiogenesis	angiogenesis	NN
cord-003921-8r8z0otz	257	13	in	in	IN
cord-003921-8r8z0otz	257	14	transplanted	transplant	VBN
cord-003921-8r8z0otz	257	15	hypoxic	hypoxic	JJ
cord-003921-8r8z0otz	257	16	tissue	tissue	NN
cord-003921-8r8z0otz	257	17	Identification	identification	NN
cord-003921-8r8z0otz	257	18	and	and	CC
cord-003921-8r8z0otz	257	19	characterization	characterization	NN
cord-003921-8r8z0otz	257	20	of	of	IN
cord-003921-8r8z0otz	257	21	VEGF	VEGF	NNP
cord-003921-8r8z0otz	257	22	-	-	HYPH
cord-003921-8r8z0otz	257	23	Aresponsive	Aresponsive	NNP
cord-003921-8r8z0otz	257	24	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	257	25	expressing	express	VBG
cord-003921-8r8z0otz	257	26	CD49d	CD49d	NNP
cord-003921-8r8z0otz	257	27	,	,	,
cord-003921-8r8z0otz	257	28	VEGFR1	VEGFR1	NNP
cord-003921-8r8z0otz	257	29	,	,	,
cord-003921-8r8z0otz	257	30	and	and	CC
cord-003921-8r8z0otz	257	31	CXCR4	CXCR4	NNS
cord-003921-8r8z0otz	257	32	in	in	IN
cord-003921-8r8z0otz	257	33	mice	mouse	NNS
cord-003921-8r8z0otz	257	34	and	and	CC
cord-003921-8r8z0otz	257	35	humans	human	NNS
cord-003921-8r8z0otz	257	36	Host	host	VBP
cord-003921-8r8z0otz	257	37	non	non	JJ
cord-003921-8r8z0otz	257	38	-	-	JJ
cord-003921-8r8z0otz	257	39	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	257	40	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	258	1	mediate	mediate	VB
cord-003921-8r8z0otz	258	2	the	the	DT
cord-003921-8r8z0otz	258	3	engraftment	engraftment	NN
cord-003921-8r8z0otz	258	4	of	of	IN
cord-003921-8r8z0otz	258	5	bioengineered	bioengineered	JJ
cord-003921-8r8z0otz	258	6	vascular	vascular	JJ
cord-003921-8r8z0otz	258	7	networks	network	NNS
cord-003921-8r8z0otz	258	8	Phagocyte	Phagocyte	NNP
cord-003921-8r8z0otz	258	9	partnership	partnership	NN
cord-003921-8r8z0otz	258	10	during	during	IN
cord-003921-8r8z0otz	258	11	the	the	DT
cord-003921-8r8z0otz	258	12	onset	onset	NN
cord-003921-8r8z0otz	258	13	and	and	CC
cord-003921-8r8z0otz	258	14	resolution	resolution	NN
cord-003921-8r8z0otz	258	15	of	of	IN
cord-003921-8r8z0otz	258	16	inflammation	inflammation	NN
cord-003921-8r8z0otz	258	17	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	258	18	cell	cell	NN
cord-003921-8r8z0otz	258	19	death	death	NN
cord-003921-8r8z0otz	258	20	in	in	IN
cord-003921-8r8z0otz	258	21	response	response	NN
cord-003921-8r8z0otz	258	22	to	to	IN
cord-003921-8r8z0otz	258	23	infection	infection	NN
cord-003921-8r8z0otz	258	24	and	and	CC
cord-003921-8r8z0otz	258	25	its	-PRON-	PRP$
cord-003921-8r8z0otz	258	26	relation	relation	NN
cord-003921-8r8z0otz	258	27	to	to	IN
cord-003921-8r8z0otz	258	28	coagulation	coagulation	NN
cord-003921-8r8z0otz	258	29	Expression	expression	NN
cord-003921-8r8z0otz	258	30	of	of	IN
cord-003921-8r8z0otz	258	31	functional	functional	JJ
cord-003921-8r8z0otz	258	32	tissue	tissue	NN
cord-003921-8r8z0otz	258	33	factor	factor	NN
cord-003921-8r8z0otz	258	34	by	by	IN
cord-003921-8r8z0otz	258	35	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	258	36	extracellular	extracellular	JJ
cord-003921-8r8z0otz	258	37	traps	trap	NNS
cord-003921-8r8z0otz	258	38	in	in	IN
cord-003921-8r8z0otz	258	39	culprit	culprit	JJ
cord-003921-8r8z0otz	258	40	artery	artery	NN
cord-003921-8r8z0otz	258	41	of	of	IN
cord-003921-8r8z0otz	258	42	acute	acute	JJ
cord-003921-8r8z0otz	258	43	myocardial	myocardial	JJ
cord-003921-8r8z0otz	258	44	infarction	infarction	NN
cord-003921-8r8z0otz	258	45	Tissue	tissue	NN
cord-003921-8r8z0otz	258	46	factor	factor	NN
cord-003921-8r8z0otz	258	47	expression	expression	NN
cord-003921-8r8z0otz	258	48	in	in	IN
cord-003921-8r8z0otz	258	49	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	258	50	extracellular	extracellular	JJ
cord-003921-8r8z0otz	258	51	traps	trap	NNS
cord-003921-8r8z0otz	258	52	and	and	CC
cord-003921-8r8z0otz	259	1	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	259	2	derived	derive	VBN
cord-003921-8r8z0otz	259	3	microparticles	microparticle	NNS
cord-003921-8r8z0otz	259	4	in	in	IN
cord-003921-8r8z0otz	259	5	antineutrophil	antineutrophil	JJ
cord-003921-8r8z0otz	259	6	cytoplasmic	cytoplasmic	JJ
cord-003921-8r8z0otz	259	7	antibody	antibody	NN
cord-003921-8r8z0otz	259	8	associated	associate	VBN
cord-003921-8r8z0otz	259	9	vasculitis	vasculitis	NN
cord-003921-8r8z0otz	259	10	may	may	MD
cord-003921-8r8z0otz	259	11	promote	promote	VB
cord-003921-8r8z0otz	259	12	thromboinflammation	thromboinflammation	NN
cord-003921-8r8z0otz	259	13	and	and	CC
cord-003921-8r8z0otz	259	14	the	the	DT
cord-003921-8r8z0otz	259	15	thrombophilic	thrombophilic	JJ
cord-003921-8r8z0otz	259	16	state	state	NN
cord-003921-8r8z0otz	259	17	associated	associate	VBN
cord-003921-8r8z0otz	259	18	with	with	IN
cord-003921-8r8z0otz	259	19	the	the	DT
cord-003921-8r8z0otz	259	20	disease	disease	NN
cord-003921-8r8z0otz	259	21	Platelets	platelet	NNS
cord-003921-8r8z0otz	259	22	and	and	CC
cord-003921-8r8z0otz	259	23	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	259	24	extracellular	extracellular	JJ
cord-003921-8r8z0otz	259	25	traps	trap	NNS
cord-003921-8r8z0otz	259	26	collaborate	collaborate	VBP
cord-003921-8r8z0otz	259	27	to	to	TO
cord-003921-8r8z0otz	259	28	promote	promote	VB
cord-003921-8r8z0otz	259	29	intravascular	intravascular	JJ
cord-003921-8r8z0otz	259	30	coagulation	coagulation	NN
cord-003921-8r8z0otz	259	31	during	during	IN
cord-003921-8r8z0otz	259	32	sepsis	sepsis	NN
cord-003921-8r8z0otz	259	33	in	in	IN
cord-003921-8r8z0otz	259	34	mice	mouse	NNS
cord-003921-8r8z0otz	260	1	Infection	infection	NN
cord-003921-8r8z0otz	260	2	-	-	HYPH
cord-003921-8r8z0otz	260	3	induced	induce	VBN
cord-003921-8r8z0otz	260	4	NETosis	NETosis	NNP
cord-003921-8r8z0otz	260	5	is	be	VBZ
cord-003921-8r8z0otz	260	6	a	a	DT
cord-003921-8r8z0otz	260	7	dynamic	dynamic	JJ
cord-003921-8r8z0otz	260	8	process	process	NN
cord-003921-8r8z0otz	260	9	involving	involve	VBG
cord-003921-8r8z0otz	260	10	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	260	11	multitasking	multitasking	NN
cord-003921-8r8z0otz	260	12	in	in	IN
cord-003921-8r8z0otz	260	13	vivo	vivo	NN
cord-003921-8r8z0otz	261	1	Interesting	interesting	JJ
cord-003921-8r8z0otz	261	2	study	study	NN
cord-003921-8r8z0otz	261	3	highlighting	highlight	VBG
cord-003921-8r8z0otz	261	4	the	the	DT
cord-003921-8r8z0otz	261	5	ability	ability	NN
cord-003921-8r8z0otz	261	6	of	of	IN
cord-003921-8r8z0otz	261	7	excessive	excessive	JJ
cord-003921-8r8z0otz	261	8	NETs	net	NNS
cord-003921-8r8z0otz	261	9	inhibition	inhibition	NN
cord-003921-8r8z0otz	261	10	to	to	TO
cord-003921-8r8z0otz	261	11	cause	cause	VB
cord-003921-8r8z0otz	261	12	pathogen	pathogen	NN
cord-003921-8r8z0otz	261	13	spread	spread	NN
cord-003921-8r8z0otz	261	14	and	and	CC
cord-003921-8r8z0otz	261	15	increase	increase	VB
cord-003921-8r8z0otz	261	16	inflammation	inflammation	NN
cord-003921-8r8z0otz	262	1	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	262	2	extracellular	extracellular	JJ
cord-003921-8r8z0otz	262	3	traps	trap	NNS
cord-003921-8r8z0otz	262	4	induce	induce	VBP
cord-003921-8r8z0otz	262	5	organ	organ	NN
cord-003921-8r8z0otz	262	6	damage	damage	NN
cord-003921-8r8z0otz	262	7	during	during	IN
cord-003921-8r8z0otz	262	8	experimental	experimental	JJ
cord-003921-8r8z0otz	262	9	and	and	CC
cord-003921-8r8z0otz	262	10	clinical	clinical	JJ
cord-003921-8r8z0otz	262	11	sepsis	sepsis	NN
cord-003921-8r8z0otz	263	1	Aggregated	aggregated	JJ
cord-003921-8r8z0otz	263	2	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	263	3	extracellular	extracellular	JJ
cord-003921-8r8z0otz	263	4	traps	trap	NNS
cord-003921-8r8z0otz	263	5	limit	limit	VBP
cord-003921-8r8z0otz	263	6	inflammation	inflammation	NN
cord-003921-8r8z0otz	263	7	by	by	IN
cord-003921-8r8z0otz	263	8	degrading	degrade	VBG
cord-003921-8r8z0otz	263	9	cytokines	cytokine	NNS
cord-003921-8r8z0otz	263	10	and	and	CC
cord-003921-8r8z0otz	263	11	chemokines	chemokine	NNS
cord-003921-8r8z0otz	263	12	Acute	acute	JJ
cord-003921-8r8z0otz	263	13	respiratory	respiratory	JJ
cord-003921-8r8z0otz	263	14	distress	distress	NN
cord-003921-8r8z0otz	263	15	syndrome	syndrome	NN
cord-003921-8r8z0otz	263	16	after	after	IN
cord-003921-8r8z0otz	263	17	orthotopic	orthotopic	JJ
cord-003921-8r8z0otz	263	18	liver	liver	NN
cord-003921-8r8z0otz	263	19	transplantation	transplantation	NN
cord-003921-8r8z0otz	263	20	Early	early	JJ
cord-003921-8r8z0otz	263	21	acute	acute	JJ
cord-003921-8r8z0otz	263	22	kidney	kidney	NN
cord-003921-8r8z0otz	263	23	injury	injury	NN
cord-003921-8r8z0otz	263	24	after	after	IN
cord-003921-8r8z0otz	263	25	liver	liver	NN
cord-003921-8r8z0otz	263	26	transplantation	transplantation	NN
cord-003921-8r8z0otz	263	27	:	:	:
cord-003921-8r8z0otz	263	28	predisposing	predispose	VBG
cord-003921-8r8z0otz	263	29	factors	factor	NNS
cord-003921-8r8z0otz	263	30	and	and	CC
cord-003921-8r8z0otz	263	31	clinical	clinical	JJ
cord-003921-8r8z0otz	263	32	implications	implication	NNS
cord-003921-8r8z0otz	264	1	Resolution	resolution	NN
cord-003921-8r8z0otz	264	2	of	of	IN
cord-003921-8r8z0otz	264	3	inflammation	inflammation	NN
cord-003921-8r8z0otz	264	4	by	by	IN
cord-003921-8r8z0otz	264	5	retrograde	retrograde	JJ
cord-003921-8r8z0otz	264	6	chemotaxis	chemotaxis	NN
cord-003921-8r8z0otz	264	7	of	of	IN
cord-003921-8r8z0otz	264	8	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	264	9	in	in	IN
cord-003921-8r8z0otz	264	10	transgenic	transgenic	JJ
cord-003921-8r8z0otz	264	11	zebrafish	zebrafish	NN
cord-003921-8r8z0otz	264	12	A	a	DT
cord-003921-8r8z0otz	264	13	zebrafish	zebrafish	NN
cord-003921-8r8z0otz	264	14	compound	compound	NN
cord-003921-8r8z0otz	264	15	screen	screen	NN
cord-003921-8r8z0otz	264	16	reveals	reveal	VBZ
cord-003921-8r8z0otz	264	17	modulation	modulation	NN
cord-003921-8r8z0otz	264	18	of	of	IN
cord-003921-8r8z0otz	264	19	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	264	20	reverse	reverse	JJ
cord-003921-8r8z0otz	264	21	migration	migration	NN
cord-003921-8r8z0otz	264	22	as	as	IN
cord-003921-8r8z0otz	264	23	an	an	DT
cord-003921-8r8z0otz	264	24	anti	anti	JJ
cord-003921-8r8z0otz	264	25	-	-	JJ
cord-003921-8r8z0otz	264	26	inflammatory	inflammatory	JJ
cord-003921-8r8z0otz	264	27	mechanism	mechanism	NN
cord-003921-8r8z0otz	264	28	The	the	DT
cord-003921-8r8z0otz	264	29	junctional	junctional	JJ
cord-003921-8r8z0otz	264	30	adhesion	adhesion	NN
cord-003921-8r8z0otz	264	31	molecule	molecule	NN
cord-003921-8r8z0otz	264	32	JAM	jam	NN
cord-003921-8r8z0otz	264	33	-	-	HYPH
cord-003921-8r8z0otz	264	34	C	C	NNP
cord-003921-8r8z0otz	264	35	regulates	regulate	VBZ
cord-003921-8r8z0otz	264	36	polarized	polarized	JJ
cord-003921-8r8z0otz	264	37	transendothelial	transendothelial	JJ
cord-003921-8r8z0otz	264	38	migration	migration	NN
cord-003921-8r8z0otz	264	39	of	of	IN
cord-003921-8r8z0otz	264	40	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	264	41	in	in	IN
cord-003921-8r8z0otz	265	1	vivo	vivo	NNP
cord-003921-8r8z0otz	265	2	Leukotriene	Leukotriene	NNP
cord-003921-8r8z0otz	265	3	B4-neutrophil	B4-neutrophil	NNP
cord-003921-8r8z0otz	265	4	elastase	elastase	NN
cord-003921-8r8z0otz	265	5	axis	axis	NN
cord-003921-8r8z0otz	265	6	drives	drive	VBZ
cord-003921-8r8z0otz	265	7	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	265	8	reverse	reverse	VBP
cord-003921-8r8z0otz	265	9	transendothelial	transendothelial	JJ
cord-003921-8r8z0otz	265	10	cell	cell	NN
cord-003921-8r8z0otz	265	11	migration	migration	NN
cord-003921-8r8z0otz	265	12	in	in	IN
cord-003921-8r8z0otz	265	13	vivo	vivo	NNP
cord-003921-8r8z0otz	265	14	Reversemigrated	reversemigrate	VBN
cord-003921-8r8z0otz	265	15	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	265	16	regulated	regulate	VBN
cord-003921-8r8z0otz	265	17	by	by	IN
cord-003921-8r8z0otz	265	18	JAM	jam	NN
cord-003921-8r8z0otz	265	19	-	-	HYPH
cord-003921-8r8z0otz	265	20	C	C	NNP
cord-003921-8r8z0otz	265	21	are	be	VBP
cord-003921-8r8z0otz	265	22	involved	involve	VBN
cord-003921-8r8z0otz	265	23	in	in	IN
cord-003921-8r8z0otz	265	24	acute	acute	JJ
cord-003921-8r8z0otz	265	25	pancreatitis	pancreatitis	NN
cord-003921-8r8z0otz	265	26	-	-	HYPH
cord-003921-8r8z0otz	265	27	associated	associate	VBN
cord-003921-8r8z0otz	265	28	lung	lung	NN
cord-003921-8r8z0otz	265	29	injury	injury	NN
cord-003921-8r8z0otz	266	1	Interferon	interferon	NN
cord-003921-8r8z0otz	266	2	regulatory	regulatory	JJ
cord-003921-8r8z0otz	266	3	factor	factor	NN
cord-003921-8r8z0otz	266	4	3	3	CD
cord-003921-8r8z0otz	266	5	deficiency	deficiency	NN
cord-003921-8r8z0otz	266	6	leads	lead	VBZ
cord-003921-8r8z0otz	266	7	to	to	IN
cord-003921-8r8z0otz	266	8	interleukin-17-mediated	interleukin-17-mediated	NNP
cord-003921-8r8z0otz	266	9	liver	liver	NN
cord-003921-8r8z0otz	266	10	ischemia	ischemia	NN
cord-003921-8r8z0otz	266	11	-	-	HYPH
cord-003921-8r8z0otz	266	12	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	266	13	injury	injury	NN
cord-003921-8r8z0otz	267	1	The	the	DT
cord-003921-8r8z0otz	267	2	fibrinderived	fibrinderived	JJ
cord-003921-8r8z0otz	267	3	peptide	peptide	NN
cord-003921-8r8z0otz	267	4	bbeta15	bbeta15	NNP
cord-003921-8r8z0otz	267	5	-	-	HYPH
cord-003921-8r8z0otz	267	6	42	42	CD
cord-003921-8r8z0otz	267	7	attenuates	attenuate	VBZ
cord-003921-8r8z0otz	267	8	liver	liver	NN
cord-003921-8r8z0otz	267	9	damage	damage	NN
cord-003921-8r8z0otz	267	10	in	in	IN
cord-003921-8r8z0otz	267	11	a	a	DT
cord-003921-8r8z0otz	267	12	rat	rat	NN
cord-003921-8r8z0otz	267	13	model	model	NN
cord-003921-8r8z0otz	267	14	of	of	IN
cord-003921-8r8z0otz	267	15	liver	liver	NN
cord-003921-8r8z0otz	267	16	ischemia	ischemia	NN
cord-003921-8r8z0otz	267	17	/	/	SYM
cord-003921-8r8z0otz	267	18	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	267	19	injury	injury	NN
cord-003921-8r8z0otz	268	1	Bruton	Bruton	NNP
cord-003921-8r8z0otz	268	2	tyrosine	tyrosine	NN
cord-003921-8r8z0otz	268	3	kinase	kinase	NN
cord-003921-8r8z0otz	268	4	inhibition	inhibition	NN
cord-003921-8r8z0otz	268	5	attenuates	attenuate	VBZ
cord-003921-8r8z0otz	268	6	liver	liver	NN
cord-003921-8r8z0otz	268	7	damage	damage	NN
cord-003921-8r8z0otz	268	8	in	in	IN
cord-003921-8r8z0otz	268	9	a	a	DT
cord-003921-8r8z0otz	268	10	mouse	mouse	NN
cord-003921-8r8z0otz	268	11	warm	warm	JJ
cord-003921-8r8z0otz	268	12	ischemia	ischemia	NN
cord-003921-8r8z0otz	268	13	and	and	CC
cord-003921-8r8z0otz	268	14	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	268	15	model	model	NN
cord-003921-8r8z0otz	269	1	The	the	DT
cord-003921-8r8z0otz	269	2	N	n	CD
cord-003921-8r8z0otz	269	3	-	-	HYPH
cord-003921-8r8z0otz	269	4	terminal	terminal	NN
cord-003921-8r8z0otz	269	5	domain	domain	NN
cord-003921-8r8z0otz	269	6	of	of	IN
cord-003921-8r8z0otz	269	7	thrombomodulin	thrombomodulin	NNP
cord-003921-8r8z0otz	269	8	sequesters	sequester	VBZ
cord-003921-8r8z0otz	269	9	high	high	JJ
cord-003921-8r8z0otz	269	10	-	-	HYPH
cord-003921-8r8z0otz	269	11	mobility	mobility	NN
cord-003921-8r8z0otz	269	12	group	group	NN
cord-003921-8r8z0otz	269	13	-	-	HYPH
cord-003921-8r8z0otz	269	14	B1	b1	NN
cord-003921-8r8z0otz	269	15	protein	protein	NN
cord-003921-8r8z0otz	269	16	,	,	,
cord-003921-8r8z0otz	269	17	a	a	DT
cord-003921-8r8z0otz	269	18	novel	novel	JJ
cord-003921-8r8z0otz	269	19	antiinflammatory	antiinflammatory	JJ
cord-003921-8r8z0otz	269	20	mechanism	mechanism	NN
cord-003921-8r8z0otz	270	1	Soluble	soluble	JJ
cord-003921-8r8z0otz	270	2	thrombomodulin	thrombomodulin	NNP
cord-003921-8r8z0otz	270	3	attenuates	attenuate	VBZ
cord-003921-8r8z0otz	270	4	sinusoidal	sinusoidal	JJ
cord-003921-8r8z0otz	270	5	obstruction	obstruction	NN
cord-003921-8r8z0otz	270	6	syndrome	syndrome	NN
cord-003921-8r8z0otz	270	7	in	in	IN
cord-003921-8r8z0otz	270	8	rat	rat	NN
cord-003921-8r8z0otz	270	9	through	through	IN
cord-003921-8r8z0otz	270	10	suppression	suppression	NN
cord-003921-8r8z0otz	270	11	of	of	IN
cord-003921-8r8z0otz	270	12	high	high	JJ
cord-003921-8r8z0otz	270	13	mobility	mobility	NN
cord-003921-8r8z0otz	270	14	group	group	NN
cord-003921-8r8z0otz	270	15	box	box	NN
cord-003921-8r8z0otz	270	16	1	1	CD
cord-003921-8r8z0otz	271	1	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	271	2	elastase	elastase	NN
cord-003921-8r8z0otz	271	3	enhances	enhance	VBZ
cord-003921-8r8z0otz	271	4	sputum	sputum	NN
cord-003921-8r8z0otz	271	5	solubilization	solubilization	NN
cord-003921-8r8z0otz	271	6	in	in	IN
cord-003921-8r8z0otz	271	7	cystic	cystic	JJ
cord-003921-8r8z0otz	271	8	fibrosis	fibrosis	NN
cord-003921-8r8z0otz	271	9	patients	patient	NNS
cord-003921-8r8z0otz	271	10	receiving	receive	VBG
cord-003921-8r8z0otz	271	11	DNase	DNase	NNP
cord-003921-8r8z0otz	271	12	therapy	therapy	NN
cord-003921-8r8z0otz	271	13	Molecular	molecular	JJ
cord-003921-8r8z0otz	271	14	mechanisms	mechanism	NNS
cord-003921-8r8z0otz	271	15	of	of	IN
cord-003921-8r8z0otz	271	16	NET	net	JJ
cord-003921-8r8z0otz	271	17	formation	formation	NN
cord-003921-8r8z0otz	271	18	and	and	CC
cord-003921-8r8z0otz	271	19	degradation	degradation	NN
cord-003921-8r8z0otz	271	20	revealed	reveal	VBN
cord-003921-8r8z0otz	271	21	by	by	IN
cord-003921-8r8z0otz	271	22	intravital	intravital	NNP
cord-003921-8r8z0otz	271	23	imaging	imaging	NN
cord-003921-8r8z0otz	271	24	in	in	IN
cord-003921-8r8z0otz	271	25	the	the	DT
cord-003921-8r8z0otz	271	26	liver	liver	NN
cord-003921-8r8z0otz	271	27	vasculature	vasculature	NN
cord-003921-8r8z0otz	272	1	The	the	DT
cord-003921-8r8z0otz	272	2	emerging	emerge	VBG
cord-003921-8r8z0otz	272	3	role	role	NN
cord-003921-8r8z0otz	272	4	of	of	IN
cord-003921-8r8z0otz	272	5	T	T	NNP
cord-003921-8r8z0otz	272	6	cell	cell	NN
cord-003921-8r8z0otz	272	7	immunoglobulin	immunoglobulin	NN
cord-003921-8r8z0otz	272	8	mucin-1	mucin-1	NNP
cord-003921-8r8z0otz	272	9	in	in	IN
cord-003921-8r8z0otz	272	10	the	the	DT
cord-003921-8r8z0otz	272	11	mechanism	mechanism	NN
cord-003921-8r8z0otz	272	12	of	of	IN
cord-003921-8r8z0otz	272	13	liver	liver	NN
cord-003921-8r8z0otz	272	14	ischemia	ischemia	NN
cord-003921-8r8z0otz	272	15	and	and	CC
cord-003921-8r8z0otz	272	16	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	272	17	injury	injury	NN
cord-003921-8r8z0otz	272	18	in	in	IN
cord-003921-8r8z0otz	272	19	the	the	DT
cord-003921-8r8z0otz	272	20	mouse	mouse	NN
cord-003921-8r8z0otz	272	21	T	t	NN
cord-003921-8r8z0otz	272	22	-	-	HYPH
cord-003921-8r8z0otz	272	23	cell	cell	NN
cord-003921-8r8z0otz	272	24	immunoglobulin	immunoglobulin	NN
cord-003921-8r8z0otz	272	25	mucin-3	mucin-3	NN
cord-003921-8r8z0otz	272	26	determines	determine	VBZ
cord-003921-8r8z0otz	272	27	severity	severity	NN
cord-003921-8r8z0otz	272	28	of	of	IN
cord-003921-8r8z0otz	272	29	liver	liver	NN
cord-003921-8r8z0otz	272	30	ischemia	ischemia	NN
cord-003921-8r8z0otz	272	31	/	/	SYM
cord-003921-8r8z0otz	272	32	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	272	33	injury	injury	NN
cord-003921-8r8z0otz	272	34	in	in	IN
cord-003921-8r8z0otz	272	35	mice	mouse	NNS
cord-003921-8r8z0otz	272	36	in	in	IN
cord-003921-8r8z0otz	272	37	a	a	DT
cord-003921-8r8z0otz	272	38	TLR4-dependent	tlr4-dependent	NN
cord-003921-8r8z0otz	272	39	manner	manner	NN
cord-003921-8r8z0otz	272	40	CD4	CD4	NNP
cord-003921-8r8z0otz	272	41	T	T	NNP
cord-003921-8r8z0otz	272	42	cells	cell	NNS
cord-003921-8r8z0otz	272	43	promote	promote	VBP
cord-003921-8r8z0otz	272	44	tissue	tissue	NN
cord-003921-8r8z0otz	272	45	inflammation	inflammation	NN
cord-003921-8r8z0otz	272	46	via	via	IN
cord-003921-8r8z0otz	272	47	CD40	CD40	NNP
cord-003921-8r8z0otz	272	48	signaling	signal	VBG
cord-003921-8r8z0otz	272	49	without	without	IN
cord-003921-8r8z0otz	272	50	de	de	NNP
cord-003921-8r8z0otz	272	51	novo	novo	NNP
cord-003921-8r8z0otz	272	52	activation	activation	NN
cord-003921-8r8z0otz	272	53	in	in	IN
cord-003921-8r8z0otz	272	54	a	a	DT
cord-003921-8r8z0otz	272	55	murine	murine	JJ
cord-003921-8r8z0otz	272	56	model	model	NN
cord-003921-8r8z0otz	272	57	of	of	IN
cord-003921-8r8z0otz	272	58	liver	liver	NN
cord-003921-8r8z0otz	272	59	ischemia	ischemia	NN
cord-003921-8r8z0otz	272	60	/	/	SYM
cord-003921-8r8z0otz	272	61	reperfusion	reperfusion	NN
cord-003921-8r8z0otz	272	62	injury	injury	NN
cord-003921-8r8z0otz	272	63	Recovery	recovery	NN
cord-003921-8r8z0otz	272	64	of	of	IN
cord-003921-8r8z0otz	272	65	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	272	66	apoptosis	apoptosis	NN
cord-003921-8r8z0otz	272	67	by	by	IN
cord-003921-8r8z0otz	272	68	ectoine	ectoine	NN
cord-003921-8r8z0otz	272	69	:	:	:
cord-003921-8r8z0otz	272	70	a	a	DT
cord-003921-8r8z0otz	272	71	new	new	JJ
cord-003921-8r8z0otz	272	72	strategy	strategy	NN
cord-003921-8r8z0otz	272	73	against	against	IN
cord-003921-8r8z0otz	272	74	lung	lung	NN
cord-003921-8r8z0otz	272	75	inflammation	inflammation	NN
cord-003921-8r8z0otz	272	76	Reduction	Reduction	NNP
cord-003921-8r8z0otz	272	77	of	of	IN
cord-003921-8r8z0otz	272	78	neutrophilic	neutrophilic	JJ
cord-003921-8r8z0otz	272	79	lung	lung	NN
cord-003921-8r8z0otz	272	80	inflammation	inflammation	NN
cord-003921-8r8z0otz	272	81	by	by	IN
cord-003921-8r8z0otz	272	82	inhalation	inhalation	NN
cord-003921-8r8z0otz	272	83	of	of	IN
cord-003921-8r8z0otz	272	84	the	the	DT
cord-003921-8r8z0otz	272	85	compatible	compatible	JJ
cord-003921-8r8z0otz	272	86	solute	solute	NN
cord-003921-8r8z0otz	272	87	ectoine	ectoine	NN
cord-003921-8r8z0otz	272	88	:	:	:
cord-003921-8r8z0otz	272	89	a	a	DT
cord-003921-8r8z0otz	272	90	randomized	randomized	JJ
cord-003921-8r8z0otz	272	91	trial	trial	NN
cord-003921-8r8z0otz	272	92	with	with	IN
cord-003921-8r8z0otz	272	93	elderly	elderly	JJ
cord-003921-8r8z0otz	272	94	individuals	individual	NNS
cord-003921-8r8z0otz	272	95	Neutrophil	Neutrophil	NNP
cord-003921-8r8z0otz	272	96	mobilization	mobilization	NN
cord-003921-8r8z0otz	272	97	and	and	CC
cord-003921-8r8z0otz	272	98	clearance	clearance	NN
cord-003921-8r8z0otz	272	99	in	in	IN
cord-003921-8r8z0otz	273	1	the	the	DT
cord-003921-8r8z0otz	273	2	bone	bone	NN
cord-003921-8r8z0otz	273	3	marrow	marrow	NN
cord-003921-8r8z0otz	273	4	Turning	turn	VBG
cord-003921-8r8z0otz	273	5	on	on	IN
cord-003921-8r8z0otz	273	6	the	the	DT
cord-003921-8r8z0otz	273	7	lights	light	NNS
cord-003921-8r8z0otz	273	8	inside	inside	IN
cord-003921-8r8z0otz	273	9	neutrophils	neutrophil	NNS
cord-003921-8r8z0otz	273	10	Catchup	Catchup	NNP
cord-003921-8r8z0otz	273	11	:	:	:
cord-003921-8r8z0otz	273	12	a	a	DT
cord-003921-8r8z0otz	273	13	mouse	mouse	NN
cord-003921-8r8z0otz	273	14	model	model	NN
cord-003921-8r8z0otz	273	15	for	for	IN
cord-003921-8r8z0otz	273	16	imaging	imaging	NN
cord-003921-8r8z0otz	273	17	-	-	HYPH
cord-003921-8r8z0otz	273	18	based	base	VBN
cord-003921-8r8z0otz	273	19	tracking	tracking	NN
cord-003921-8r8z0otz	273	20	and	and	CC
cord-003921-8r8z0otz	273	21	modulation	modulation	NN
cord-003921-8r8z0otz	273	22	of	of	IN
cord-003921-8r8z0otz	273	23	neutrophil	neutrophil	NN
cord-003921-8r8z0otz	273	24	granulocytes	granulocyte	NNS