id sid tid token lemma pos cord-012618-ulqajban 1 1 key key JJ cord-012618-ulqajban 1 2 : : : cord-012618-ulqajban 1 3 cord-012618-ulqajban cord-012618-ulqajban NNP cord-012618-ulqajban 2 1 authors author NNS cord-012618-ulqajban 2 2 : : : cord-012618-ulqajban 2 3 Jiang Jiang NNP cord-012618-ulqajban 2 4 , , , cord-012618-ulqajban 3 1 Hai Hai NNP cord-012618-ulqajban 3 2 title title NN cord-012618-ulqajban 3 3 : : : cord-012618-ulqajban 4 1 The the DT cord-012618-ulqajban 4 2 expanding expand VBG cord-012618-ulqajban 4 3 vulnerabilities vulnerability NNS cord-012618-ulqajban 4 4 of of IN cord-012618-ulqajban 4 5 being be VBG cord-012618-ulqajban 4 6 UTXless utxless JJ cord-012618-ulqajban 4 7 date date NN cord-012618-ulqajban 4 8 : : : cord-012618-ulqajban 4 9 2019 2019 CD cord-012618-ulqajban 4 10 - - HYPH cord-012618-ulqajban 4 11 04 04 CD cord-012618-ulqajban 4 12 - - SYM cord-012618-ulqajban 4 13 26 26 CD cord-012618-ulqajban 4 14 journal journal NN cord-012618-ulqajban 4 15 : : : cord-012618-ulqajban 5 1 Signal Signal NNP cord-012618-ulqajban 5 2 Transduct Transduct NNP cord-012618-ulqajban 5 3 Target Target NNP cord-012618-ulqajban 6 1 Ther ther JJ cord-012618-ulqajban 6 2 DOI DOI NNP cord-012618-ulqajban 6 3 : : : cord-012618-ulqajban 7 1 10.1038 10.1038 CD cord-012618-ulqajban 7 2 / / SYM cord-012618-ulqajban 7 3 s41392 s41392 NNP cord-012618-ulqajban 7 4 - - HYPH cord-012618-ulqajban 7 5 019 019 CD cord-012618-ulqajban 8 1 -0043-z -0043-z JJ cord-012618-ulqajban 9 1 sha sha NNP cord-012618-ulqajban 9 2 : : : cord-012618-ulqajban 10 1 c68b2a35a3fdf25082b92abbb1e12592e3d360a5 c68b2a35a3fdf25082b92abbb1e12592e3d360a5 NNP cord-012618-ulqajban 10 2 doc_id doc_id NNP cord-012618-ulqajban 10 3 : : : cord-012618-ulqajban 11 1 12618 12618 CD cord-012618-ulqajban 11 2 cord_uid cord_uid NNS cord-012618-ulqajban 11 3 : : : cord-012618-ulqajban 11 4 ulqajban ulqajban NNP cord-012618-ulqajban 11 5 nan nan NNP cord-012618-ulqajban 12 1 In in IN cord-012618-ulqajban 12 2 a a DT cord-012618-ulqajban 12 3 recent recent JJ cord-012618-ulqajban 12 4 study study NN cord-012618-ulqajban 12 5 . . . cord-012618-ulqajban 13 1 1 1 CD cord-012618-ulqajban 13 2 published publish VBN cord-012618-ulqajban 13 3 in in IN cord-012618-ulqajban 13 4 Signal Signal NNP cord-012618-ulqajban 13 5 Transduction Transduction NNP cord-012618-ulqajban 13 6 and and CC cord-012618-ulqajban 13 7 Targeted Targeted NNP cord-012618-ulqajban 13 8 Therapy Therapy NNP cord-012618-ulqajban 13 9 , , , cord-012618-ulqajban 13 10 Dr. Dr. NNP cord-012618-ulqajban 13 11 Yu Yu NNP cord-012618-ulqajban 13 12 Liu Liu NNP cord-012618-ulqajban 13 13 and and CC cord-012618-ulqajban 13 14 collaborators collaborator NNS cord-012618-ulqajban 13 15 report report VBP cord-012618-ulqajban 13 16 that that IN cord-012618-ulqajban 13 17 the the DT cord-012618-ulqajban 13 18 differentiation differentiation NN cord-012618-ulqajban 13 19 block block NN cord-012618-ulqajban 13 20 in in IN cord-012618-ulqajban 13 21 UTX UTX NNP cord-012618-ulqajban 13 22 - - HYPH cord-012618-ulqajban 13 23 null null NN cord-012618-ulqajban 13 24 leukemia leukemia NN cord-012618-ulqajban 13 25 cells cell NNS cord-012618-ulqajban 13 26 can can MD cord-012618-ulqajban 13 27 be be VB cord-012618-ulqajban 13 28 reverted revert VBN cord-012618-ulqajban 13 29 by by IN cord-012618-ulqajban 13 30 an an DT cord-012618-ulqajban 13 31 LSD1 LSD1 NNP cord-012618-ulqajban 13 32 inhibitor inhibitor NN cord-012618-ulqajban 13 33 , , , cord-012618-ulqajban 13 34 highlighting highlight VBG cord-012618-ulqajban 13 35 additional additional JJ cord-012618-ulqajban 13 36 ways way NNS cord-012618-ulqajban 13 37 of of IN cord-012618-ulqajban 13 38 targeting target VBG cord-012618-ulqajban 13 39 UTX UTX NNP cord-012618-ulqajban 13 40 - - HYPH cord-012618-ulqajban 13 41 deficient deficient JJ cord-012618-ulqajban 13 42 malignancies malignancy NNS cord-012618-ulqajban 13 43 . . . cord-012618-ulqajban 14 1 UTX UTX NNP cord-012618-ulqajban 14 2 is be VBZ cord-012618-ulqajban 14 3 an an DT cord-012618-ulqajban 14 4 important important JJ cord-012618-ulqajban 14 5 epigenetic epigenetic JJ cord-012618-ulqajban 14 6 regulator regulator NN cord-012618-ulqajban 14 7 , , , cord-012618-ulqajban 14 8 and and CC cord-012618-ulqajban 14 9 many many JJ cord-012618-ulqajban 14 10 human human JJ cord-012618-ulqajban 14 11 cancers cancer NNS cord-012618-ulqajban 14 12 harbor harbor VBP cord-012618-ulqajban 14 13 mutations mutation NNS cord-012618-ulqajban 14 14 or or CC cord-012618-ulqajban 14 15 deletions deletion NNS cord-012618-ulqajban 14 16 in in IN cord-012618-ulqajban 14 17 this this DT cord-012618-ulqajban 14 18 gene gene NN cord-012618-ulqajban 14 19 . . . cord-012618-ulqajban 15 1 2 2 LS cord-012618-ulqajban 16 1 A a DT cord-012618-ulqajban 16 2 series series NN cord-012618-ulqajban 16 3 of of IN cord-012618-ulqajban 16 4 recent recent JJ cord-012618-ulqajban 16 5 studies study NNS cord-012618-ulqajban 16 6 have have VBP cord-012618-ulqajban 16 7 established establish VBN cord-012618-ulqajban 16 8 the the DT cord-012618-ulqajban 16 9 role role NN cord-012618-ulqajban 16 10 of of IN cord-012618-ulqajban 16 11 UTX UTX NNP cord-012618-ulqajban 16 12 as as IN cord-012618-ulqajban 16 13 a a DT cord-012618-ulqajban 16 14 tumor tumor NN cord-012618-ulqajban 16 15 suppressor suppressor NN cord-012618-ulqajban 16 16 in in IN cord-012618-ulqajban 16 17 leukemia leukemia NN cord-012618-ulqajban 16 18 , , , cord-012618-ulqajban 16 19 lymphoma lymphoma NN cord-012618-ulqajban 16 20 , , , cord-012618-ulqajban 16 21 pancreatic pancreatic NN cord-012618-ulqajban 16 22 , , , cord-012618-ulqajban 16 23 and and CC cord-012618-ulqajban 16 24 lung lung NN cord-012618-ulqajban 16 25 cancers cancer NNS cord-012618-ulqajban 16 26 . . . cord-012618-ulqajban 17 1 [ [ -LRB- cord-012618-ulqajban 17 2 3 3 CD cord-012618-ulqajban 17 3 ] ] -RRB- cord-012618-ulqajban 17 4 [ [ -LRB- cord-012618-ulqajban 17 5 4 4 CD cord-012618-ulqajban 17 6 ] ] -RRB- cord-012618-ulqajban 17 7 [ [ -LRB- cord-012618-ulqajban 17 8 5 5 CD cord-012618-ulqajban 17 9 ] ] -RRB- cord-012618-ulqajban 17 10 [ [ -LRB- cord-012618-ulqajban 17 11 6 6 CD cord-012618-ulqajban 17 12 ] ] -RRB- cord-012618-ulqajban 17 13 [ [ -LRB- cord-012618-ulqajban 17 14 7 7 CD cord-012618-ulqajban 17 15 ] ] -RRB- cord-012618-ulqajban 18 1 In in IN cord-012618-ulqajban 18 2 particular particular JJ cord-012618-ulqajban 18 3 , , , cord-012618-ulqajban 18 4 it -PRON- PRP cord-012618-ulqajban 18 5 was be VBD cord-012618-ulqajban 18 6 also also RB cord-012618-ulqajban 18 7 demonstrated demonstrate VBN cord-012618-ulqajban 18 8 that that IN cord-012618-ulqajban 18 9 UTX UTX NNP cord-012618-ulqajban 18 10 escapes escape VBZ cord-012618-ulqajban 18 11 from from IN cord-012618-ulqajban 18 12 X x NN cord-012618-ulqajban 18 13 chromosome chromosome NN cord-012618-ulqajban 18 14 inactivation inactivation NN cord-012618-ulqajban 18 15 , , , cord-012618-ulqajban 18 16 therefore therefore RB cord-012618-ulqajban 18 17 females female NNS cord-012618-ulqajban 18 18 have have VBP cord-012618-ulqajban 18 19 more more JJR cord-012618-ulqajban 18 20 functional functional JJ cord-012618-ulqajban 18 21 copies copy NNS cord-012618-ulqajban 18 22 of of IN cord-012618-ulqajban 18 23 this this DT cord-012618-ulqajban 18 24 tumor tumor NN cord-012618-ulqajban 18 25 suppressor suppressor NN cord-012618-ulqajban 18 26 than than IN cord-012618-ulqajban 18 27 do do VBP cord-012618-ulqajban 18 28 males male NNS cord-012618-ulqajban 18 29 , , , cord-012618-ulqajban 18 30 and and CC cord-012618-ulqajban 18 31 different different JJ cord-012618-ulqajban 18 32 dosages dosage NNS cord-012618-ulqajban 18 33 of of IN cord-012618-ulqajban 18 34 UTX UTX NNP cord-012618-ulqajban 18 35 in in IN cord-012618-ulqajban 18 36 male male NN cord-012618-ulqajban 18 37 and and CC cord-012618-ulqajban 18 38 females female NNS cord-012618-ulqajban 18 39 contribute contribute VBP cord-012618-ulqajban 18 40 to to IN cord-012618-ulqajban 18 41 cancer cancer NN cord-012618-ulqajban 18 42 sex sex NN cord-012618-ulqajban 18 43 bias bias NN cord-012618-ulqajban 18 44 . . . cord-012618-ulqajban 19 1 5 5 LS cord-012618-ulqajban 19 2 , , , cord-012618-ulqajban 19 3 8 8 CD cord-012618-ulqajban 19 4 Biochemically biochemically RB cord-012618-ulqajban 19 5 , , , cord-012618-ulqajban 19 6 UTX UTX NNP cord-012618-ulqajban 19 7 is be VBZ cord-012618-ulqajban 19 8 a a DT cord-012618-ulqajban 19 9 histone histone NN cord-012618-ulqajban 19 10 demethylase demethylase NN cord-012618-ulqajban 19 11 that that WDT cord-012618-ulqajban 19 12 removes remove VBZ cord-012618-ulqajban 19 13 methyl methyl NN cord-012618-ulqajban 19 14 groups group NNS cord-012618-ulqajban 19 15 from from IN cord-012618-ulqajban 19 16 tri tri NNP cord-012618-ulqajban 19 17 - - : cord-012618-ulqajban 19 18 and and CC cord-012618-ulqajban 19 19 di di NN cord-012618-ulqajban 19 20 - - HYPH cord-012618-ulqajban 19 21 methyl methyl JJ cord-012618-ulqajban 19 22 H3K27 H3K27 NNP cord-012618-ulqajban 19 23 , , , cord-012618-ulqajban 19 24 which which WDT cord-012618-ulqajban 19 25 negatively negatively RB cord-012618-ulqajban 19 26 regulates regulate VBZ cord-012618-ulqajban 19 27 gene gene NN cord-012618-ulqajban 19 28 expression expression NN cord-012618-ulqajban 19 29 . . . cord-012618-ulqajban 20 1 The the DT cord-012618-ulqajban 20 2 loss loss NN cord-012618-ulqajban 20 3 of of IN cord-012618-ulqajban 20 4 UTX UTX NNP cord-012618-ulqajban 20 5 , , , cord-012618-ulqajban 20 6 therefore therefore RB cord-012618-ulqajban 20 7 , , , cord-012618-ulqajban 20 8 has have VBZ cord-012618-ulqajban 20 9 been be VBN cord-012618-ulqajban 20 10 demonstrated demonstrate VBN cord-012618-ulqajban 20 11 to to TO cord-012618-ulqajban 20 12 affect affect VB cord-012618-ulqajban 20 13 gene gene NN cord-012618-ulqajban 20 14 expression expression NN cord-012618-ulqajban 20 15 , , , cord-012618-ulqajban 20 16 cellular cellular JJ cord-012618-ulqajban 20 17 differentiation differentiation NN cord-012618-ulqajban 20 18 , , , cord-012618-ulqajban 20 19 and and CC cord-012618-ulqajban 20 20 embryonic embryonic JJ cord-012618-ulqajban 20 21 development development NN cord-012618-ulqajban 20 22 . . . cord-012618-ulqajban 21 1 In in IN cord-012618-ulqajban 21 2 many many JJ cord-012618-ulqajban 21 3 cancer cancer NN cord-012618-ulqajban 21 4 models model NNS cord-012618-ulqajban 21 5 , , , cord-012618-ulqajban 21 6 the the DT cord-012618-ulqajban 21 7 role role NN cord-012618-ulqajban 21 8 of of IN cord-012618-ulqajban 21 9 UTX UTX NNP cord-012618-ulqajban 21 10 as as IN cord-012618-ulqajban 21 11 a a DT cord-012618-ulqajban 21 12 tumor tumor NN cord-012618-ulqajban 21 13 suppressor suppressor NN cord-012618-ulqajban 21 14 has have VBZ cord-012618-ulqajban 21 15 been be VBN cord-012618-ulqajban 21 16 linked link VBN cord-012618-ulqajban 21 17 to to IN cord-012618-ulqajban 21 18 epigenetic epigenetic JJ cord-012618-ulqajban 21 19 changes change NNS cord-012618-ulqajban 21 20 associated associate VBN cord-012618-ulqajban 21 21 with with IN cord-012618-ulqajban 21 22 UTX UTX NNP cord-012618-ulqajban 21 23 loss loss NN cord-012618-ulqajban 21 24 . . . cord-012618-ulqajban 22 1 4 4 LS cord-012618-ulqajban 22 2 , , , cord-012618-ulqajban 22 3 7 7 CD cord-012618-ulqajban 22 4 Significant significant JJ cord-012618-ulqajban 22 5 changes change NNS cord-012618-ulqajban 22 6 in in IN cord-012618-ulqajban 22 7 enhancer enhancer NN cord-012618-ulqajban 22 8 and and CC cord-012618-ulqajban 22 9 chromatin chromatin NN cord-012618-ulqajban 22 10 accessibility accessibility NN cord-012618-ulqajban 22 11 were be VBD cord-012618-ulqajban 22 12 observed observe VBN cord-012618-ulqajban 22 13 in in IN cord-012618-ulqajban 22 14 UTX UTX NNP cord-012618-ulqajban 22 15 knockout knockout NN cord-012618-ulqajban 22 16 cancer cancer NN cord-012618-ulqajban 22 17 models model NNS cord-012618-ulqajban 22 18 , , , cord-012618-ulqajban 22 19 and and CC cord-012618-ulqajban 22 20 an an DT cord-012618-ulqajban 22 21 enzyme enzyme NN cord-012618-ulqajban 22 22 activity activity NN cord-012618-ulqajban 22 23 - - HYPH cord-012618-ulqajban 22 24 independent independent JJ cord-012618-ulqajban 22 25 role role NN cord-012618-ulqajban 22 26 has have VBZ cord-012618-ulqajban 22 27 also also RB cord-012618-ulqajban 22 28 been be VBN cord-012618-ulqajban 22 29 proposed propose VBN cord-012618-ulqajban 22 30 for for IN cord-012618-ulqajban 22 31 UTX UTX NNP cord-012618-ulqajban 22 32 as as IN cord-012618-ulqajban 22 33 a a DT cord-012618-ulqajban 22 34 tumor tumor NN cord-012618-ulqajban 22 35 suppressor suppressor NN cord-012618-ulqajban 22 36 . . . cord-012618-ulqajban 23 1 4 4 LS cord-012618-ulqajban 23 2 , , , cord-012618-ulqajban 23 3 7 7 CD cord-012618-ulqajban 23 4 Several several JJ cord-012618-ulqajban 23 5 studies study NNS cord-012618-ulqajban 23 6 have have VBP cord-012618-ulqajban 23 7 shown show VBN cord-012618-ulqajban 23 8 that that IN cord-012618-ulqajban 23 9 UTX utx NN cord-012618-ulqajban 23 10 - - HYPH cord-012618-ulqajban 23 11 deficient deficient JJ cord-012618-ulqajban 23 12 cancers cancer NNS cord-012618-ulqajban 23 13 are be VBP cord-012618-ulqajban 23 14 more more RBR cord-012618-ulqajban 23 15 aggressive aggressive JJ cord-012618-ulqajban 23 16 and and CC cord-012618-ulqajban 23 17 can can MD cord-012618-ulqajban 23 18 lead lead VB cord-012618-ulqajban 23 19 to to IN cord-012618-ulqajban 23 20 poor poor JJ cord-012618-ulqajban 23 21 patient patient NN cord-012618-ulqajban 23 22 survival survival NN cord-012618-ulqajban 23 23 . . . cord-012618-ulqajban 24 1 4 4 LS cord-012618-ulqajban 24 2 , , , cord-012618-ulqajban 24 3 5 5 CD cord-012618-ulqajban 24 4 , , , cord-012618-ulqajban 24 5 9 9 CD cord-012618-ulqajban 25 1 An an DT cord-012618-ulqajban 25 2 important important JJ cord-012618-ulqajban 25 3 question question NN cord-012618-ulqajban 25 4 is be VBZ cord-012618-ulqajban 25 5 how how WRB cord-012618-ulqajban 25 6 to to TO cord-012618-ulqajban 25 7 develop develop VB cord-012618-ulqajban 25 8 specific specific JJ cord-012618-ulqajban 25 9 strategies strategy NNS cord-012618-ulqajban 25 10 to to IN cord-012618-ulqajban 25 11 more more RBR cord-012618-ulqajban 25 12 effectively effectively RB cord-012618-ulqajban 25 13 treat treat VB cord-012618-ulqajban 25 14 these these DT cord-012618-ulqajban 25 15 UTX UTX NNP cord-012618-ulqajban 25 16 - - HYPH cord-012618-ulqajban 25 17 deficient deficient JJ cord-012618-ulqajban 25 18 cancers cancer NNS cord-012618-ulqajban 25 19 . . . cord-012618-ulqajban 26 1 Several several JJ cord-012618-ulqajban 26 2 lines line NNS cord-012618-ulqajban 26 3 of of IN cord-012618-ulqajban 26 4 evidence evidence NN cord-012618-ulqajban 26 5 have have VBP cord-012618-ulqajban 26 6 been be VBN cord-012618-ulqajban 26 7 established establish VBN cord-012618-ulqajban 26 8 ( ( -LRB- cord-012618-ulqajban 26 9 Fig Fig NNP cord-012618-ulqajban 26 10 . . . cord-012618-ulqajban 26 11 1 1 CD cord-012618-ulqajban 26 12 ) ) -RRB- cord-012618-ulqajban 26 13 . . . cord-012618-ulqajban 27 1 First first RB cord-012618-ulqajban 27 2 , , , cord-012618-ulqajban 27 3 since since IN cord-012618-ulqajban 27 4 UTX UTX NNP cord-012618-ulqajban 27 5 is be VBZ cord-012618-ulqajban 27 6 a a DT cord-012618-ulqajban 27 7 H3K27 H3K27 NNP cord-012618-ulqajban 27 8 demethylase demethylase NN cord-012618-ulqajban 27 9 , , , cord-012618-ulqajban 27 10 several several JJ cord-012618-ulqajban 27 11 research research NN cord-012618-ulqajban 27 12 groups group NNS cord-012618-ulqajban 27 13 have have VBP cord-012618-ulqajban 27 14 shown show VBN cord-012618-ulqajban 27 15 that that IN cord-012618-ulqajban 27 16 inhibitors inhibitor NNS cord-012618-ulqajban 27 17 of of IN cord-012618-ulqajban 27 18 EZH2 EZH2 NNP cord-012618-ulqajban 27 19 , , , cord-012618-ulqajban 27 20 the the DT cord-012618-ulqajban 27 21 H3K27 H3K27 NNP cord-012618-ulqajban 27 22 methyltransferase methyltransferase NN cord-012618-ulqajban 27 23 , , , cord-012618-ulqajban 27 24 can can MD cord-012618-ulqajban 27 25 strongly strongly RB cord-012618-ulqajban 27 26 inhibit inhibit VB cord-012618-ulqajban 27 27 the the DT cord-012618-ulqajban 27 28 growth growth NN cord-012618-ulqajban 27 29 of of IN cord-012618-ulqajban 27 30 UTXdeficient utxdeficient JJ cord-012618-ulqajban 27 31 cancers cancer NNS cord-012618-ulqajban 27 32 . . . cord-012618-ulqajban 28 1 6 6 CD cord-012618-ulqajban 28 2 , , , cord-012618-ulqajban 28 3 9 9 CD cord-012618-ulqajban 28 4 Second second JJ cord-012618-ulqajban 28 5 , , , cord-012618-ulqajban 28 6 in in IN cord-012618-ulqajban 28 7 pancreatic pancreatic JJ cord-012618-ulqajban 28 8 cancer cancer NN cord-012618-ulqajban 28 9 models model NNS cord-012618-ulqajban 28 10 it -PRON- PRP cord-012618-ulqajban 28 11 was be VBD cord-012618-ulqajban 28 12 found find VBN cord-012618-ulqajban 28 13 that that IN cord-012618-ulqajban 28 14 UTX utx NN cord-012618-ulqajban 28 15 - - HYPH cord-012618-ulqajban 28 16 deficient deficient JJ cord-012618-ulqajban 28 17 cancer cancer NN cord-012618-ulqajban 28 18 is be VBZ cord-012618-ulqajban 28 19 sensitive sensitive JJ cord-012618-ulqajban 28 20 to to TO cord-012618-ulqajban 28 21 BET bet NN cord-012618-ulqajban 28 22 inhibitors inhibitor NNS cord-012618-ulqajban 28 23 , , , cord-012618-ulqajban 28 24 which which WDT cord-012618-ulqajban 28 25 restrain restrain VBP cord-012618-ulqajban 28 26 gene gene NN cord-012618-ulqajban 28 27 expression expression NN cord-012618-ulqajban 28 28 from from IN cord-012618-ulqajban 28 29 super super JJ cord-012618-ulqajban 28 30 - - NNS cord-012618-ulqajban 28 31 enhancers enhancer NNS cord-012618-ulqajban 28 32 that that WDT cord-012618-ulqajban 28 33 are be VBP cord-012618-ulqajban 28 34 altered alter VBN cord-012618-ulqajban 28 35 by by IN cord-012618-ulqajban 28 36 UTX UTX NNP cord-012618-ulqajban 28 37 loss loss NN cord-012618-ulqajban 28 38 . . . cord-012618-ulqajban 29 1 4 4 LS cord-012618-ulqajban 29 2 Third Third NNP cord-012618-ulqajban 29 3 , , , cord-012618-ulqajban 29 4 two two CD cord-012618-ulqajban 29 5 separate separate JJ cord-012618-ulqajban 29 6 studies study NNS cord-012618-ulqajban 29 7 suggest suggest VBP cord-012618-ulqajban 29 8 that that IN cord-012618-ulqajban 29 9 the the DT cord-012618-ulqajban 29 10 cellular cellular JJ cord-012618-ulqajban 29 11 sensitivity sensitivity NN cord-012618-ulqajban 29 12 to to IN cord-012618-ulqajban 29 13 cytarabine cytarabine NNP cord-012618-ulqajban 29 14 , , , cord-012618-ulqajban 29 15 a a DT cord-012618-ulqajban 29 16 cytosine cytosine NN cord-012618-ulqajban 29 17 analog analog NN cord-012618-ulqajban 29 18 that that WDT cord-012618-ulqajban 29 19 inhibits inhibit VBZ cord-012618-ulqajban 29 20 DNA dna NN cord-012618-ulqajban 29 21 synthesis synthesis NN cord-012618-ulqajban 29 22 , , , cord-012618-ulqajban 29 23 is be VBZ cord-012618-ulqajban 29 24 potentially potentially RB cord-012618-ulqajban 29 25 affected affect VBN cord-012618-ulqajban 29 26 by by IN cord-012618-ulqajban 29 27 the the DT cord-012618-ulqajban 29 28 H3K27 H3K27 NNP cord-012618-ulqajban 29 29 methylation methylation NN cord-012618-ulqajban 29 30 status status NN cord-012618-ulqajban 29 31 . . . cord-012618-ulqajban 30 1 In in IN cord-012618-ulqajban 30 2 AML AML NNP cord-012618-ulqajban 30 3 , , , cord-012618-ulqajban 30 4 the the DT cord-012618-ulqajban 30 5 loss loss NN cord-012618-ulqajban 30 6 of of IN cord-012618-ulqajban 30 7 the the DT cord-012618-ulqajban 30 8 H3K27 H3K27 NNP cord-012618-ulqajban 31 1 methyltransferase methyltransferase NNP cord-012618-ulqajban 31 2 EZH2 EZH2 NNP cord-012618-ulqajban 31 3 induced induce VBN cord-012618-ulqajban 31 4 resistance resistance NN cord-012618-ulqajban 31 5 to to IN cord-012618-ulqajban 31 6 cytarabine cytarabine NN cord-012618-ulqajban 31 7 , , , cord-012618-ulqajban 31 8 10 10 CD cord-012618-ulqajban 31 9 whereas whereas RB cord-012618-ulqajban 31 10 in in IN cord-012618-ulqajban 31 11 lymphoma lymphoma NN cord-012618-ulqajban 31 12 models model NNS cord-012618-ulqajban 31 13 the the DT cord-012618-ulqajban 31 14 loss loss NN cord-012618-ulqajban 31 15 of of IN cord-012618-ulqajban 31 16 the the DT cord-012618-ulqajban 31 17 H3K27 H3K27 NNP cord-012618-ulqajban 31 18 demethylase demethylase NN cord-012618-ulqajban 32 1 UTX UTX NNP cord-012618-ulqajban 32 2 sensitized sensitize VBD cord-012618-ulqajban 32 3 the the DT cord-012618-ulqajban 32 4 cells cell NNS cord-012618-ulqajban 32 5 to to IN cord-012618-ulqajban 32 6 this this DT cord-012618-ulqajban 32 7 drug drug NN cord-012618-ulqajban 32 8 . . . cord-012618-ulqajban 33 1 5 5 LS cord-012618-ulqajban 34 1 It -PRON- PRP cord-012618-ulqajban 34 2 remains remain VBZ cord-012618-ulqajban 34 3 interesting interesting JJ cord-012618-ulqajban 34 4 to to TO cord-012618-ulqajban 34 5 determine determine VB cord-012618-ulqajban 34 6 whether whether IN cord-012618-ulqajban 34 7 the the DT cord-012618-ulqajban 34 8 above above JJ cord-012618-ulqajban 34 9 findings finding NNS cord-012618-ulqajban 34 10 , , , cord-012618-ulqajban 34 11 if if IN cord-012618-ulqajban 34 12 applied apply VBN cord-012618-ulqajban 34 13 in in IN cord-012618-ulqajban 34 14 clinics clinic NNS cord-012618-ulqajban 34 15 , , , cord-012618-ulqajban 34 16 could could MD cord-012618-ulqajban 34 17 enhance enhance VB cord-012618-ulqajban 34 18 the the DT cord-012618-ulqajban 34 19 treatment treatment NN cord-012618-ulqajban 34 20 outcome outcome NN cord-012618-ulqajban 34 21 of of IN cord-012618-ulqajban 34 22 UTX UTX NNP cord-012618-ulqajban 34 23 - - HYPH cord-012618-ulqajban 34 24 deficient deficient JJ cord-012618-ulqajban 34 25 tumors tumor NNS cord-012618-ulqajban 34 26 . . . cord-012618-ulqajban 35 1 In in IN cord-012618-ulqajban 35 2 an an DT cord-012618-ulqajban 35 3 interesting interesting JJ cord-012618-ulqajban 35 4 paper paper NN cord-012618-ulqajban 35 5 in in IN cord-012618-ulqajban 35 6 this this DT cord-012618-ulqajban 35 7 issue issue NN cord-012618-ulqajban 35 8 of of IN cord-012618-ulqajban 35 9 Signal Signal NNP cord-012618-ulqajban 35 10 Transduction Transduction NNP cord-012618-ulqajban 35 11 and and CC cord-012618-ulqajban 35 12 Targeted Targeted NNP cord-012618-ulqajban 35 13 Therapy Therapy NNP cord-012618-ulqajban 35 14 , , , cord-012618-ulqajban 35 15 research research NN cord-012618-ulqajban 35 16 conducted conduct VBN cord-012618-ulqajban 35 17 by by IN cord-012618-ulqajban 35 18 Dr. Dr. NNP cord-012618-ulqajban 35 19 Yu Yu NNP cord-012618-ulqajban 35 20 Liu Liu NNP cord-012618-ulqajban 35 21 's 's POS cord-012618-ulqajban 35 22 group group NN cord-012618-ulqajban 35 23 1 1 CD cord-012618-ulqajban 35 24 has have VBZ cord-012618-ulqajban 35 25 further further RB cord-012618-ulqajban 35 26 expanded expand VBN cord-012618-ulqajban 35 27 the the DT cord-012618-ulqajban 35 28 weaponry weaponry NN cord-012618-ulqajban 35 29 against against IN cord-012618-ulqajban 35 30 UTX UTX NNP cord-012618-ulqajban 35 31 - - HYPH cord-012618-ulqajban 35 32 deficient deficient JJ cord-012618-ulqajban 35 33 malignancies malignancy NNS cord-012618-ulqajban 35 34 . . . cord-012618-ulqajban 36 1 To to TO cord-012618-ulqajban 36 2 further further RB cord-012618-ulqajban 36 3 explore explore VB cord-012618-ulqajban 36 4 the the DT cord-012618-ulqajban 36 5 potential potential JJ cord-012618-ulqajban 36 6 pharmacological pharmacological JJ cord-012618-ulqajban 36 7 weakness weakness NN cord-012618-ulqajban 36 8 of of IN cord-012618-ulqajban 36 9 being be VBG cord-012618-ulqajban 36 10 UTX utx NN cord-012618-ulqajban 36 11 - - HYPH cord-012618-ulqajban 36 12 deficient deficient JJ cord-012618-ulqajban 36 13 , , , cord-012618-ulqajban 36 14 an an DT cord-012618-ulqajban 36 15 elegant elegant JJ cord-012618-ulqajban 36 16 model model NN cord-012618-ulqajban 36 17 of of IN cord-012618-ulqajban 36 18 UTX UTX NNP cord-012618-ulqajban 36 19 - - HYPH cord-012618-ulqajban 36 20 null null JJ cord-012618-ulqajban 36 21 hematopoietic hematopoietic JJ cord-012618-ulqajban 36 22 stem stem NN cord-012618-ulqajban 36 23 and and CC cord-012618-ulqajban 36 24 progenitor progenitor NN cord-012618-ulqajban 36 25 cells cell NNS cord-012618-ulqajban 36 26 ( ( -LRB- cord-012618-ulqajban 36 27 HSPCs hspc NNS cord-012618-ulqajban 36 28 ) ) -RRB- cord-012618-ulqajban 36 29 was be VBD cord-012618-ulqajban 36 30 employed employ VBN cord-012618-ulqajban 36 31 . . . cord-012618-ulqajban 37 1 In in IN cord-012618-ulqajban 37 2 human human JJ cord-012618-ulqajban 37 3 patients patient NNS cord-012618-ulqajban 37 4 , , , cord-012618-ulqajban 37 5 UTX UTX NNP cord-012618-ulqajban 37 6 mutation mutation NN cord-012618-ulqajban 37 7 in in IN cord-012618-ulqajban 37 8 this this DT cord-012618-ulqajban 37 9 cell cell NN cord-012618-ulqajban 37 10 type type NN cord-012618-ulqajban 37 11 causes cause VBZ cord-012618-ulqajban 37 12 a a DT cord-012618-ulqajban 37 13 differentiation differentiation NN cord-012618-ulqajban 37 14 block block NN cord-012618-ulqajban 37 15 that that WDT cord-012618-ulqajban 37 16 contributes contribute VBZ cord-012618-ulqajban 37 17 to to IN cord-012618-ulqajban 37 18 the the DT cord-012618-ulqajban 37 19 development development NN cord-012618-ulqajban 37 20 of of IN cord-012618-ulqajban 37 21 MDS MDS NNP cord-012618-ulqajban 37 22 and and CC cord-012618-ulqajban 37 23 AML AML NNP cord-012618-ulqajban 37 24 . . . cord-012618-ulqajban 38 1 While while IN cord-012618-ulqajban 38 2 screening screen VBG cord-012618-ulqajban 38 3 for for IN cord-012618-ulqajban 38 4 small small JJ cord-012618-ulqajban 38 5 molecules molecule NNS cord-012618-ulqajban 38 6 that that WDT cord-012618-ulqajban 38 7 are be VBP cord-012618-ulqajban 38 8 able able JJ cord-012618-ulqajban 38 9 to to TO cord-012618-ulqajban 38 10 release release VB cord-012618-ulqajban 38 11 such such PDT cord-012618-ulqajban 38 12 a a DT cord-012618-ulqajban 38 13 differentiation differentiation NN cord-012618-ulqajban 38 14 block block NN cord-012618-ulqajban 38 15 , , , cord-012618-ulqajban 38 16 the the DT cord-012618-ulqajban 38 17 authors author NNS cord-012618-ulqajban 38 18 identified identify VBD cord-012618-ulqajban 38 19 SP2509 SP2509 NNP cord-012618-ulqajban 38 20 , , , cord-012618-ulqajban 38 21 a a DT cord-012618-ulqajban 38 22 selective selective JJ cord-012618-ulqajban 38 23 inhibitor inhibitor NN cord-012618-ulqajban 38 24 of of IN cord-012618-ulqajban 38 25 the the DT cord-012618-ulqajban 38 26 H3K4 H3K4 NNP cord-012618-ulqajban 38 27 demethylase demethylase NNP cord-012618-ulqajban 38 28 LSD1 LSD1 NNP cord-012618-ulqajban 38 29 . . . cord-012618-ulqajban 39 1 Ensuing ensuing NN cord-012618-ulqajban 39 2 studies study NNS cord-012618-ulqajban 39 3 demonstrated demonstrate VBD cord-012618-ulqajban 39 4 that that IN cord-012618-ulqajban 39 5 SP2509 SP2509 NNP cord-012618-ulqajban 39 6 promoted promote VBD cord-012618-ulqajban 39 7 the the DT cord-012618-ulqajban 39 8 differentiation differentiation NN cord-012618-ulqajban 39 9 of of IN cord-012618-ulqajban 39 10 UTXnull UTXnull NNS cord-012618-ulqajban 39 11 HSPCs hspc NNS cord-012618-ulqajban 39 12 but but CC cord-012618-ulqajban 39 13 not not RB cord-012618-ulqajban 39 14 wild wild JJ cord-012618-ulqajban 39 15 type type NN cord-012618-ulqajban 39 16 HSPCs hspc NNS cord-012618-ulqajban 39 17 . . . cord-012618-ulqajban 40 1 Gene gene NN cord-012618-ulqajban 40 2 signatures signature NNS cord-012618-ulqajban 40 3 in in IN cord-012618-ulqajban 40 4 UTX UTX NNP cord-012618-ulqajban 40 5 - - HYPH cord-012618-ulqajban 40 6 null null JJ cord-012618-ulqajban 40 7 HSPCs hspc NNS cord-012618-ulqajban 40 8 were be VBD cord-012618-ulqajban 40 9 also also RB cord-012618-ulqajban 40 10 reverted revert VBN cord-012618-ulqajban 40 11 by by IN cord-012618-ulqajban 40 12 this this DT cord-012618-ulqajban 40 13 drug drug NN cord-012618-ulqajban 40 14 . . . cord-012618-ulqajban 41 1 Importantly importantly RB cord-012618-ulqajban 41 2 , , , cord-012618-ulqajban 41 3 from from IN cord-012618-ulqajban 41 4 a a DT cord-012618-ulqajban 41 5 cancer cancer NN cord-012618-ulqajban 41 6 treatment treatment NN cord-012618-ulqajban 41 7 perspective perspective NN cord-012618-ulqajban 41 8 , , , cord-012618-ulqajban 41 9 SP2509 SP2509 NNP cord-012618-ulqajban 41 10 promoted promote VBD cord-012618-ulqajban 41 11 the the DT cord-012618-ulqajban 41 12 differentiation differentiation NN cord-012618-ulqajban 41 13 of of IN cord-012618-ulqajban 41 14 UTX UTX NNP cord-012618-ulqajban 41 15 - - HYPH cord-012618-ulqajban 41 16 deficient deficient JJ cord-012618-ulqajban 41 17 AML AML NNP cord-012618-ulqajban 41 18 cells cell NNS cord-012618-ulqajban 41 19 in in IN cord-012618-ulqajban 41 20 vivo vivo NN cord-012618-ulqajban 41 21 and and CC cord-012618-ulqajban 41 22 extended extended JJ cord-012618-ulqajban 41 23 mice mice NN cord-012618-ulqajban 41 24 survival survival NN cord-012618-ulqajban 41 25 . . . cord-012618-ulqajban 42 1 These these DT cord-012618-ulqajban 42 2 findings finding NNS cord-012618-ulqajban 42 3 convincingly convincingly RB cord-012618-ulqajban 42 4 demonstrated demonstrate VBD cord-012618-ulqajban 42 5 that that IN cord-012618-ulqajban 42 6 H3K4 H3K4 NNP cord-012618-ulqajban 42 7 methylation methylation NN cord-012618-ulqajban 42 8 is be VBZ cord-012618-ulqajban 42 9 crucially crucially RB cord-012618-ulqajban 42 10 involved involve VBN cord-012618-ulqajban 42 11 in in IN cord-012618-ulqajban 42 12 the the DT cord-012618-ulqajban 42 13 differentiation differentiation NN cord-012618-ulqajban 42 14 block block NN cord-012618-ulqajban 42 15 caused cause VBN cord-012618-ulqajban 42 16 by by IN cord-012618-ulqajban 42 17 UTX UTX NNP cord-012618-ulqajban 42 18 deficiency deficiency NN cord-012618-ulqajban 42 19 . . . cord-012618-ulqajban 43 1 It -PRON- PRP cord-012618-ulqajban 43 2 was be VBD cord-012618-ulqajban 43 3 also also RB cord-012618-ulqajban 43 4 the the DT cord-012618-ulqajban 43 5 first first JJ cord-012618-ulqajban 43 6 time time NN cord-012618-ulqajban 43 7 that that WDT cord-012618-ulqajban 43 8 the the DT cord-012618-ulqajban 43 9 H3K4 H3K4 NNP cord-012618-ulqajban 43 10 demethylase demethylase NN cord-012618-ulqajban 43 11 inhibitor inhibitor NN cord-012618-ulqajban 43 12 was be VBD cord-012618-ulqajban 43 13 suggested suggest VBN cord-012618-ulqajban 43 14 for for IN cord-012618-ulqajban 43 15 fighting fight VBG cord-012618-ulqajban 43 16 UTXless utxless JJ cord-012618-ulqajban 43 17 cancers cancer NNS cord-012618-ulqajban 43 18 . . . cord-012618-ulqajban 44 1 Fig Fig NNP cord-012618-ulqajban 44 2 . . . cord-012618-ulqajban 45 1 1 1 CD cord-012618-ulqajban 45 2 Loss loss NN cord-012618-ulqajban 45 3 of of IN cord-012618-ulqajban 45 4 UTX UTX NNP cord-012618-ulqajban 45 5 in in IN cord-012618-ulqajban 45 6 cancer cancer NN cord-012618-ulqajban 45 7 cells cell NNS cord-012618-ulqajban 45 8 results result NNS cord-012618-ulqajban 45 9 in in IN cord-012618-ulqajban 45 10 an an DT cord-012618-ulqajban 45 11 altered altered JJ cord-012618-ulqajban 45 12 epigenetic epigenetic JJ cord-012618-ulqajban 45 13 state state NN cord-012618-ulqajban 45 14 that that WDT cord-012618-ulqajban 45 15 renders render VBZ cord-012618-ulqajban 45 16 cancer cancer NN cord-012618-ulqajban 45 17 cells cell NNS cord-012618-ulqajban 45 18 vulnerable vulnerable JJ cord-012618-ulqajban 45 19 to to IN cord-012618-ulqajban 45 20 several several JJ cord-012618-ulqajban 45 21 small small JJ cord-012618-ulqajban 45 22 molecules molecule NNS cord-012618-ulqajban 45 23 and and CC cord-012618-ulqajban 45 24 anticancer anticancer JJ cord-012618-ulqajban 45 25 drugs drug NNS cord-012618-ulqajban 45 26 ( ( -LRB- cord-012618-ulqajban 45 27 in in IN cord-012618-ulqajban 45 28 red red NN cord-012618-ulqajban 45 29 ) ) -RRB- cord-012618-ulqajban 46 1 1 1 LS cord-012618-ulqajban 47 1 Interestingly interestingly RB cord-012618-ulqajban 47 2 , , , cord-012618-ulqajban 47 3 UTX UTX NNP cord-012618-ulqajban 47 4 often often RB cord-012618-ulqajban 47 5 coexists coexist VBZ cord-012618-ulqajban 47 6 with with IN cord-012618-ulqajban 47 7 two two CD cord-012618-ulqajban 47 8 H3K4 H3K4 NNP cord-012618-ulqajban 47 9 methyltransferases methyltransferase NNS cord-012618-ulqajban 47 10 MLL3 MLL3 NNP cord-012618-ulqajban 47 11 / / SYM cord-012618-ulqajban 47 12 MLL4 MLL4 NNP cord-012618-ulqajban 47 13 in in IN cord-012618-ulqajban 47 14 the the DT cord-012618-ulqajban 47 15 COMPASS COMPASS NNP cord-012618-ulqajban 47 16 complex complex NN cord-012618-ulqajban 47 17 . . . cord-012618-ulqajban 48 1 This this DT cord-012618-ulqajban 48 2 complex complex NN cord-012618-ulqajban 48 3 , , , cord-012618-ulqajban 48 4 by by IN cord-012618-ulqajban 48 5 coordinately coordinately RB cord-012618-ulqajban 48 6 removing remove VBG cord-012618-ulqajban 48 7 the the DT cord-012618-ulqajban 48 8 repressive repressive JJ cord-012618-ulqajban 48 9 H3K27 h3k27 NN cord-012618-ulqajban 48 10 methylation methylation NN cord-012618-ulqajban 48 11 marker marker NN cord-012618-ulqajban 48 12 and and CC cord-012618-ulqajban 48 13 establishing establish VBG cord-012618-ulqajban 48 14 the the DT cord-012618-ulqajban 48 15 active active JJ cord-012618-ulqajban 48 16 H3K4 H3K4 NNP cord-012618-ulqajban 48 17 methylation methylation NN cord-012618-ulqajban 48 18 marker marker NN cord-012618-ulqajban 48 19 , , , cord-012618-ulqajban 48 20 mediates mediate VBZ cord-012618-ulqajban 48 21 crucial crucial JJ cord-012618-ulqajban 48 22 decisions decision NNS cord-012618-ulqajban 48 23 in in IN cord-012618-ulqajban 48 24 gene gene NN cord-012618-ulqajban 48 25 expression expression NN cord-012618-ulqajban 48 26 and and CC cord-012618-ulqajban 48 27 cellular cellular JJ cord-012618-ulqajban 48 28 differentiation differentiation NN cord-012618-ulqajban 48 29 . . . cord-012618-ulqajban 49 1 Indeed indeed RB cord-012618-ulqajban 49 2 , , , cord-012618-ulqajban 49 3 in in IN cord-012618-ulqajban 49 4 the the DT cord-012618-ulqajban 49 5 paper paper NN cord-012618-ulqajban 49 6 by by IN cord-012618-ulqajban 49 7 Wu Wu NNP cord-012618-ulqajban 49 8 et et NNP cord-012618-ulqajban 49 9 al al NNP cord-012618-ulqajban 49 10 . . . cord-012618-ulqajban 50 1 , , , cord-012618-ulqajban 50 2 a a DT cord-012618-ulqajban 50 3 UTX UTX NNP cord-012618-ulqajban 50 4 knockout knockout NN cord-012618-ulqajban 50 5 was be VBD cord-012618-ulqajban 50 6 shown show VBN cord-012618-ulqajban 50 7 to to TO cord-012618-ulqajban 50 8 decrease decrease VB cord-012618-ulqajban 50 9 H3K4 H3K4 NNP cord-012618-ulqajban 50 10 methylation methylation NN cord-012618-ulqajban 50 11 in in IN cord-012618-ulqajban 50 12 HSPCs hspc NNS cord-012618-ulqajban 50 13 , , , cord-012618-ulqajban 50 14 likely likely RB cord-012618-ulqajban 50 15 through through IN cord-012618-ulqajban 50 16 the the DT cord-012618-ulqajban 50 17 COMPASS COMPASS NNP cord-012618-ulqajban 50 18 - - HYPH cord-012618-ulqajban 50 19 like like JJ cord-012618-ulqajban 50 20 complex complex NN cord-012618-ulqajban 50 21 , , , cord-012618-ulqajban 50 22 and and CC cord-012618-ulqajban 50 23 the the DT cord-012618-ulqajban 50 24 LSD1 LSD1 NNP cord-012618-ulqajban 50 25 inhibitor inhibitor NN cord-012618-ulqajban 50 26 SP2509 SP2509 NNP cord-012618-ulqajban 50 27 decreased decrease VBD cord-012618-ulqajban 50 28 the the DT cord-012618-ulqajban 50 29 self self NN cord-012618-ulqajban 50 30 - - HYPH cord-012618-ulqajban 50 31 renewal renewal NN cord-012618-ulqajban 50 32 ability ability NN cord-012618-ulqajban 50 33 of of IN cord-012618-ulqajban 50 34 UTX UTX NNP cord-012618-ulqajban 50 35 - - HYPH cord-012618-ulqajban 50 36 null null JJ cord-012618-ulqajban 50 37 HSPCs hspc NNS cord-012618-ulqajban 50 38 . . . cord-012618-ulqajban 51 1 Together together RB cord-012618-ulqajban 51 2 with with IN cord-012618-ulqajban 51 3 previous previous JJ cord-012618-ulqajban 51 4 findings finding NNS cord-012618-ulqajban 51 5 , , , cord-012618-ulqajban 51 6 it -PRON- PRP cord-012618-ulqajban 51 7 seems seem VBZ cord-012618-ulqajban 51 8 that that IN cord-012618-ulqajban 51 9 UTX UTX NNP cord-012618-ulqajban 51 10 - - HYPH cord-012618-ulqajban 51 11 deficient deficient JJ cord-012618-ulqajban 51 12 cancer cancer NN cord-012618-ulqajban 51 13 cells cell NNS cord-012618-ulqajban 51 14 dance dance VBP cord-012618-ulqajban 51 15 delicately delicately RB cord-012618-ulqajban 51 16 on on IN cord-012618-ulqajban 51 17 the the DT cord-012618-ulqajban 51 18 balance balance NN cord-012618-ulqajban 51 19 between between IN cord-012618-ulqajban 51 20 H3K27 H3K27 NNP cord-012618-ulqajban 51 21 and and CC cord-012618-ulqajban 51 22 H3K4 H3K4 NNP cord-012618-ulqajban 51 23 methylation methylation NN cord-012618-ulqajban 51 24 status status NN cord-012618-ulqajban 51 25 , , , cord-012618-ulqajban 51 26 and and CC cord-012618-ulqajban 51 27 pharmacological pharmacological JJ cord-012618-ulqajban 51 28 weakness weakness NN cord-012618-ulqajban 51 29 can can MD cord-012618-ulqajban 51 30 be be VB cord-012618-ulqajban 51 31 specifically specifically RB cord-012618-ulqajban 51 32 explored explore VBN cord-012618-ulqajban 51 33 for for IN cord-012618-ulqajban 51 34 such such PDT cord-012618-ulqajban 51 35 an an DT cord-012618-ulqajban 51 36 altered altered JJ cord-012618-ulqajban 51 37 balance balance NN cord-012618-ulqajban 51 38 within within IN cord-012618-ulqajban 51 39 UTXdeficient utxdeficient JJ cord-012618-ulqajban 51 40 cancer cancer NN cord-012618-ulqajban 51 41 cells cell NNS cord-012618-ulqajban 51 42 . . . cord-012618-ulqajban 52 1 The the DT cord-012618-ulqajban 52 2 novel novel JJ cord-012618-ulqajban 52 3 findings finding NNS cord-012618-ulqajban 52 4 by by IN cord-012618-ulqajban 52 5 Wu Wu NNP cord-012618-ulqajban 52 6 et et NNP cord-012618-ulqajban 52 7 al al NNP cord-012618-ulqajban 52 8 . . . cord-012618-ulqajban 53 1 not not RB cord-012618-ulqajban 53 2 only only RB cord-012618-ulqajban 53 3 established establish VBD cord-012618-ulqajban 53 4 the the DT cord-012618-ulqajban 53 5 relevance relevance NN cord-012618-ulqajban 53 6 of of IN cord-012618-ulqajban 53 7 the the DT cord-012618-ulqajban 53 8 COMPASS COMPASS NNP cord-012618-ulqajban 53 9 complex complex NN cord-012618-ulqajban 53 10 for for IN cord-012618-ulqajban 53 11 the the DT cord-012618-ulqajban 53 12 maintenance maintenance NN cord-012618-ulqajban 53 13 of of IN cord-012618-ulqajban 53 14 the the DT cord-012618-ulqajban 53 15 UTX UTX NNP cord-012618-ulqajban 53 16 - - HYPH cord-012618-ulqajban 53 17 deficient deficient JJ cord-012618-ulqajban 53 18 cancer cancer NN cord-012618-ulqajban 53 19 state state NN cord-012618-ulqajban 53 20 but but CC cord-012618-ulqajban 53 21 also also RB cord-012618-ulqajban 53 22 highlighted highlight VBD cord-012618-ulqajban 53 23 additional additional JJ cord-012618-ulqajban 53 24 enzymatic enzymatic JJ cord-012618-ulqajban 53 25 targets target NNS cord-012618-ulqajban 53 26 in in IN cord-012618-ulqajban 53 27 the the DT cord-012618-ulqajban 53 28 fight fight NN cord-012618-ulqajban 53 29 against against IN cord-012618-ulqajban 53 30 UTXless utxless NN cord-012618-ulqajban 53 31 malignancies malignancy NNS cord-012618-ulqajban 54 1 ( ( -LRB- cord-012618-ulqajban 54 2 Fig Fig NNP cord-012618-ulqajban 54 3 . . NNP cord-012618-ulqajban 54 4 1 1 CD cord-012618-ulqajban 54 5 ) ) -RRB- cord-012618-ulqajban 54 6 . . . cord-012618-ulqajban 55 1 Epigenetic epigenetic JJ cord-012618-ulqajban 55 2 drug drug NN cord-012618-ulqajban 55 3 library library NN cord-012618-ulqajban 55 4 screening screening NN cord-012618-ulqajban 55 5 identified identify VBD cord-012618-ulqajban 55 6 an an DT cord-012618-ulqajban 55 7 LSD1 LSD1 NNP cord-012618-ulqajban 55 8 inhibitor inhibitor NN cord-012618-ulqajban 55 9 to to TO cord-012618-ulqajban 55 10 target target VB cord-012618-ulqajban 55 11 UTX UTX NNP cord-012618-ulqajban 55 12 - - HYPH cord-012618-ulqajban 55 13 deficient deficient JJ cord-012618-ulqajban 55 14 cells cell NNS cord-012618-ulqajban 55 15 for for IN cord-012618-ulqajban 55 16 differentiation differentiation NN cord-012618-ulqajban 55 17 therapy therapy NN cord-012618-ulqajban 55 18 UTX UTX NNP cord-012618-ulqajban 55 19 Mutations Mutations NNPS cord-012618-ulqajban 55 20 in in IN cord-012618-ulqajban 55 21 Human Human NNP cord-012618-ulqajban 55 22 Cancer Cancer NNP cord-012618-ulqajban 55 23 Contrasting contrast VBG cord-012618-ulqajban 55 24 roles role NNS cord-012618-ulqajban 55 25 of of IN cord-012618-ulqajban 55 26 histone histone NN cord-012618-ulqajban 55 27 3 3 CD cord-012618-ulqajban 55 28 lysine lysine NN cord-012618-ulqajban 55 29 27 27 CD cord-012618-ulqajban 55 30 demethylases demethylase NNS cord-012618-ulqajban 55 31 in in IN cord-012618-ulqajban 55 32 acute acute JJ cord-012618-ulqajban 55 33 lymphoblastic lymphoblastic JJ cord-012618-ulqajban 55 34 leukaemia leukaemia NN cord-012618-ulqajban 55 35 Loss loss NN cord-012618-ulqajban 55 36 of of IN cord-012618-ulqajban 55 37 KDM6A kdm6a CD cord-012618-ulqajban 56 1 Activates activate VBZ cord-012618-ulqajban 56 2 Super Super NNP cord-012618-ulqajban 56 3 - - HYPH cord-012618-ulqajban 56 4 Enhancers enhancer NNS cord-012618-ulqajban 56 5 to to TO cord-012618-ulqajban 56 6 Induce induce VB cord-012618-ulqajban 56 7 Gender gender NN cord-012618-ulqajban 56 8 - - HYPH cord-012618-ulqajban 56 9 Specific specific JJ cord-012618-ulqajban 56 10 Squamous squamous JJ cord-012618-ulqajban 56 11 - - HYPH cord-012618-ulqajban 56 12 like like JJ cord-012618-ulqajban 56 13 Pancreatic pancreatic JJ cord-012618-ulqajban 56 14 Cancer Cancer NNP cord-012618-ulqajban 56 15 and and CC cord-012618-ulqajban 56 16 Confers confer VBZ cord-012618-ulqajban 56 17 Sensitivity sensitivity NN cord-012618-ulqajban 57 1 to to TO cord-012618-ulqajban 57 2 BET bet VB cord-012618-ulqajban 58 1 Inhibitors Inhibitors NNP cord-012618-ulqajban 58 2 UTX UTX NNP cord-012618-ulqajban 58 3 is be VBZ cord-012618-ulqajban 58 4 an an DT cord-012618-ulqajban 58 5 escape escape NN cord-012618-ulqajban 58 6 from from IN cord-012618-ulqajban 58 7 X x NN cord-012618-ulqajban 58 8 - - NN cord-012618-ulqajban 58 9 inactivation inactivation JJ cord-012618-ulqajban 58 10 tumor tumor NN cord-012618-ulqajban 58 11 - - HYPH cord-012618-ulqajban 58 12 suppressor suppressor NN cord-012618-ulqajban 58 13 in in IN cord-012618-ulqajban 58 14 B b NN cord-012618-ulqajban 58 15 cell cell NN cord-012618-ulqajban 58 16 lymphoma lymphoma NN cord-012618-ulqajban 59 1 In in IN cord-012618-ulqajban 59 2 vivo vivo FW cord-012618-ulqajban 59 3 CRISPR CRISPR NNP cord-012618-ulqajban 59 4 screening screening NN cord-012618-ulqajban 59 5 unveils unveil VBZ cord-012618-ulqajban 59 6 histone histone NN cord-012618-ulqajban 59 7 demethylase demethylase NN cord-012618-ulqajban 59 8 UTX UTX NNP cord-012618-ulqajban 59 9 as as IN cord-012618-ulqajban 59 10 an an DT cord-012618-ulqajban 59 11 important important JJ cord-012618-ulqajban 59 12 epigenetic epigenetic JJ cord-012618-ulqajban 59 13 regulator regulator NN cord-012618-ulqajban 59 14 in in IN cord-012618-ulqajban 59 15 lung lung NN cord-012618-ulqajban 59 16 tumorigenesis tumorigenesis NN cord-012618-ulqajban 60 1 UTX UTX NNP cord-012618-ulqajban 60 2 - - HYPH cord-012618-ulqajban 60 3 mediated mediate VBN cord-012618-ulqajban 60 4 enhancer enhancer NN cord-012618-ulqajban 60 5 and and CC cord-012618-ulqajban 60 6 chromatin chromatin NN cord-012618-ulqajban 60 7 remodeling remodeling NN cord-012618-ulqajban 60 8 suppresses suppress VBZ cord-012618-ulqajban 60 9 myeloid myeloid NNP cord-012618-ulqajban 60 10 leukemogenesis leukemogenesis NNP cord-012618-ulqajban 60 11 through through IN cord-012618-ulqajban 60 12 noncatalytic noncatalytic JJ cord-012618-ulqajban 60 13 inverse inverse NN cord-012618-ulqajban 60 14 regulation regulation NN cord-012618-ulqajban 60 15 of of IN cord-012618-ulqajban 60 16 ETS ETS NNP cord-012618-ulqajban 60 17 and and CC cord-012618-ulqajban 60 18 GATA GATA NNP cord-012618-ulqajban 60 19 programs program NNS cord-012618-ulqajban 60 20 Tumor tumor NN cord-012618-ulqajban 60 21 - - HYPH cord-012618-ulqajban 60 22 suppressor suppressor NN cord-012618-ulqajban 60 23 genes gene NNS cord-012618-ulqajban 60 24 that that WDT cord-012618-ulqajban 60 25 escape escape VBP cord-012618-ulqajban 60 26 from from IN cord-012618-ulqajban 60 27 X x NN cord-012618-ulqajban 60 28 - - NN cord-012618-ulqajban 60 29 inactivation inactivation NN cord-012618-ulqajban 60 30 contribute contribute VBP cord-012618-ulqajban 60 31 to to IN cord-012618-ulqajban 60 32 cancer cancer NN cord-012618-ulqajban 60 33 sex sex NN cord-012618-ulqajban 60 34 bias bias NN cord-012618-ulqajban 61 1 UTX UTX NNP cord-012618-ulqajban 61 2 / / SYM cord-012618-ulqajban 61 3 KDM6A kdm6a CD cord-012618-ulqajban 61 4 Loss loss NN cord-012618-ulqajban 61 5 Enhances enhance VBZ cord-012618-ulqajban 61 6 the the DT cord-012618-ulqajban 61 7 Malignant malignant JJ cord-012618-ulqajban 61 8 Phenotype Phenotype NNP cord-012618-ulqajban 61 9 of of IN cord-012618-ulqajban 61 10 Multiple Multiple NNP cord-012618-ulqajban 61 11 Myeloma Myeloma NNP cord-012618-ulqajban 61 12 and and CC cord-012618-ulqajban 61 13 Sensitizes Sensitizes NNP cord-012618-ulqajban 61 14 Cells cell NNS cord-012618-ulqajban 61 15 to to IN cord-012618-ulqajban 62 1 EZH2 ezh2 JJ cord-012618-ulqajban 62 2 inhibition inhibition NN cord-012618-ulqajban 62 3 Loss loss NN cord-012618-ulqajban 62 4 of of IN cord-012618-ulqajban 62 5 the the DT cord-012618-ulqajban 62 6 histone histone NN cord-012618-ulqajban 63 1 methyltransferase methyltransferase NNP cord-012618-ulqajban 63 2 EZH2 EZH2 NNP cord-012618-ulqajban 63 3 induces induce VBZ cord-012618-ulqajban 63 4 resistance resistance NN cord-012618-ulqajban 63 5 to to IN cord-012618-ulqajban 63 6 multiple multiple JJ cord-012618-ulqajban 63 7 drugs drug NNS cord-012618-ulqajban 63 8 in in IN cord-012618-ulqajban 63 9 acute acute JJ cord-012618-ulqajban 63 10 myeloid myeloid NN cord-012618-ulqajban 63 11 leukemia leukemia NN cord-012618-ulqajban 63 12 Open Open NNP cord-012618-ulqajban 63 13 Access Access NNP cord-012618-ulqajban 63 14 This this DT cord-012618-ulqajban 63 15 article article NN cord-012618-ulqajban 63 16 is be VBZ cord-012618-ulqajban 63 17 licensed license VBN cord-012618-ulqajban 63 18 under under IN cord-012618-ulqajban 63 19 a a DT cord-012618-ulqajban 63 20 Creative Creative NNP cord-012618-ulqajban 63 21 Commons Commons NNP cord-012618-ulqajban 63 22 Attribution Attribution NNP cord-012618-ulqajban 63 23 4.0 4.0 CD cord-012618-ulqajban 63 24 International International NNP cord-012618-ulqajban 63 25 License License NNP cord-012618-ulqajban 63 26 , , , cord-012618-ulqajban 63 27 which which WDT cord-012618-ulqajban 63 28 permits permit VBZ cord-012618-ulqajban 63 29 use use NN cord-012618-ulqajban 63 30 , , , cord-012618-ulqajban 63 31 sharing sharing NN cord-012618-ulqajban 63 32 , , , cord-012618-ulqajban 63 33 adaptation adaptation NN cord-012618-ulqajban 63 34 , , , cord-012618-ulqajban 63 35 distribution distribution NN cord-012618-ulqajban 63 36 and and CC cord-012618-ulqajban 63 37 reproduction reproduction NN cord-012618-ulqajban 63 38 in in IN cord-012618-ulqajban 63 39 any any DT cord-012618-ulqajban 63 40 medium medium NN cord-012618-ulqajban 63 41 or or CC cord-012618-ulqajban 63 42 format format NN cord-012618-ulqajban 63 43 , , , cord-012618-ulqajban 63 44 as as RB cord-012618-ulqajban 63 45 long long RB cord-012618-ulqajban 63 46 as as IN cord-012618-ulqajban 63 47 you -PRON- PRP cord-012618-ulqajban 63 48 give give VBP cord-012618-ulqajban 63 49 appropriate appropriate JJ cord-012618-ulqajban 63 50 credit credit NN cord-012618-ulqajban 63 51 to to IN cord-012618-ulqajban 63 52 the the DT cord-012618-ulqajban 63 53 original original JJ cord-012618-ulqajban 63 54 author(s author(s NNP cord-012618-ulqajban 63 55 ) ) -RRB- cord-012618-ulqajban 63 56 and and CC cord-012618-ulqajban 63 57 the the DT cord-012618-ulqajban 63 58 source source NN cord-012618-ulqajban 63 59 , , , cord-012618-ulqajban 63 60 provide provide VB cord-012618-ulqajban 63 61 a a DT cord-012618-ulqajban 63 62 link link NN cord-012618-ulqajban 63 63 to to IN cord-012618-ulqajban 63 64 the the DT cord-012618-ulqajban 63 65 Creative Creative NNP cord-012618-ulqajban 63 66 Commons Commons NNP cord-012618-ulqajban 63 67 license license NN cord-012618-ulqajban 63 68 , , , cord-012618-ulqajban 63 69 and and CC cord-012618-ulqajban 63 70 indicate indicate VBP cord-012618-ulqajban 63 71 if if IN cord-012618-ulqajban 63 72 changes change NNS cord-012618-ulqajban 63 73 were be VBD cord-012618-ulqajban 63 74 made make VBN cord-012618-ulqajban 63 75 . . . cord-012618-ulqajban 64 1 The the DT cord-012618-ulqajban 64 2 images image NNS cord-012618-ulqajban 64 3 or or CC cord-012618-ulqajban 64 4 other other JJ cord-012618-ulqajban 64 5 third third JJ cord-012618-ulqajban 64 6 party party NN cord-012618-ulqajban 64 7 material material NN cord-012618-ulqajban 64 8 in in IN cord-012618-ulqajban 64 9 this this DT cord-012618-ulqajban 64 10 article article NN cord-012618-ulqajban 64 11 are be VBP cord-012618-ulqajban 64 12 included include VBN cord-012618-ulqajban 64 13 in in IN cord-012618-ulqajban 64 14 the the DT cord-012618-ulqajban 64 15 article article NN cord-012618-ulqajban 64 16 's 's POS cord-012618-ulqajban 64 17 Creative Creative NNP cord-012618-ulqajban 64 18 Commons Commons NNP cord-012618-ulqajban 64 19 license license NN cord-012618-ulqajban 64 20 , , , cord-012618-ulqajban 64 21 unless unless IN cord-012618-ulqajban 64 22 indicated indicate VBN cord-012618-ulqajban 64 23 otherwise otherwise RB cord-012618-ulqajban 64 24 in in IN cord-012618-ulqajban 64 25 a a DT cord-012618-ulqajban 64 26 credit credit NN cord-012618-ulqajban 64 27 line line NN cord-012618-ulqajban 64 28 to to IN cord-012618-ulqajban 64 29 the the DT cord-012618-ulqajban 64 30 material material NN cord-012618-ulqajban 64 31 . . . cord-012618-ulqajban 65 1 If if IN cord-012618-ulqajban 65 2 material material NN cord-012618-ulqajban 65 3 is be VBZ cord-012618-ulqajban 65 4 not not RB cord-012618-ulqajban 65 5 included include VBN cord-012618-ulqajban 65 6 in in IN cord-012618-ulqajban 65 7 the the DT cord-012618-ulqajban 65 8 article article NN cord-012618-ulqajban 65 9 's 's POS cord-012618-ulqajban 65 10 Creative Creative NNP cord-012618-ulqajban 65 11 Commons Commons NNP cord-012618-ulqajban 65 12 license license NN cord-012618-ulqajban 65 13 and and CC cord-012618-ulqajban 65 14 your -PRON- PRP$ cord-012618-ulqajban 65 15 intended intend VBN cord-012618-ulqajban 65 16 use use NN cord-012618-ulqajban 65 17 is be VBZ cord-012618-ulqajban 65 18 not not RB cord-012618-ulqajban 65 19 permitted permit VBN cord-012618-ulqajban 65 20 by by IN cord-012618-ulqajban 65 21 statutory statutory JJ cord-012618-ulqajban 65 22 regulation regulation NN cord-012618-ulqajban 65 23 or or CC cord-012618-ulqajban 65 24 exceeds exceed VBZ cord-012618-ulqajban 65 25 the the DT cord-012618-ulqajban 65 26 permitted permit VBN cord-012618-ulqajban 65 27 use use NN cord-012618-ulqajban 65 28 , , , cord-012618-ulqajban 65 29 you -PRON- PRP cord-012618-ulqajban 65 30 will will MD cord-012618-ulqajban 65 31 need need VB cord-012618-ulqajban 65 32 to to TO cord-012618-ulqajban 65 33 obtain obtain VB cord-012618-ulqajban 65 34 permission permission NN cord-012618-ulqajban 65 35 directly directly RB cord-012618-ulqajban 65 36 from from IN cord-012618-ulqajban 65 37 the the DT cord-012618-ulqajban 65 38 copyright copyright NN cord-012618-ulqajban 65 39 holder holder NN cord-012618-ulqajban 65 40 . . . cord-012618-ulqajban 66 1 To to TO cord-012618-ulqajban 66 2 view view VB cord-012618-ulqajban 66 3 a a DT cord-012618-ulqajban 66 4 copy copy NN cord-012618-ulqajban 66 5 of of IN cord-012618-ulqajban 66 6 this this DT cord-012618-ulqajban 66 7 license license NN cord-012618-ulqajban 66 8 , , , cord-012618-ulqajban 66 9 visit visit VB cord-012618-ulqajban 66 10 http://creativecommons http://creativecommon NNS cord-012618-ulqajban 66 11 . . . cord-012618-ulqajban 67 1 org org NNP cord-012618-ulqajban 67 2 / / SYM cord-012618-ulqajban 67 3 licenses license NNS cord-012618-ulqajban 67 4 / / SYM cord-012618-ulqajban 67 5 by/4.0/. by/4.0/. VBN