id sid tid token lemma pos cord-017772-zpf1xjqi 1 1 key key JJ cord-017772-zpf1xjqi 2 1 : : : cord-017772-zpf1xjqi 2 2 cord-017772-zpf1xjqi cord-017772-zpf1xjqi NNP cord-017772-zpf1xjqi 2 3 authors author NNS cord-017772-zpf1xjqi 2 4 : : : cord-017772-zpf1xjqi 3 1 Walter Walter NNP cord-017772-zpf1xjqi 3 2 , , , cord-017772-zpf1xjqi 3 3 James James NNP cord-017772-zpf1xjqi 3 4 M. M. NNP cord-017772-zpf1xjqi 3 5 title title NN cord-017772-zpf1xjqi 3 6 : : : cord-017772-zpf1xjqi 3 7 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 3 8 in in IN cord-017772-zpf1xjqi 3 9 the the DT cord-017772-zpf1xjqi 3 10 Intensive Intensive NNP cord-017772-zpf1xjqi 3 11 Care Care NNP cord-017772-zpf1xjqi 3 12 Unit Unit NNP cord-017772-zpf1xjqi 3 13 date date NN cord-017772-zpf1xjqi 3 14 : : : cord-017772-zpf1xjqi 3 15 2019 2019 CD cord-017772-zpf1xjqi 3 16 - - HYPH cord-017772-zpf1xjqi 3 17 07 07 CD cord-017772-zpf1xjqi 3 18 - - HYPH cord-017772-zpf1xjqi 3 19 24 24 CD cord-017772-zpf1xjqi 3 20 journal journal NN cord-017772-zpf1xjqi 3 21 : : : cord-017772-zpf1xjqi 4 1 Evidence evidence NN cord-017772-zpf1xjqi 4 2 - - HYPH cord-017772-zpf1xjqi 4 3 Based base VBN cord-017772-zpf1xjqi 4 4 Critical Critical NNP cord-017772-zpf1xjqi 4 5 Care care NN cord-017772-zpf1xjqi 4 6 DOI doi NN cord-017772-zpf1xjqi 4 7 : : : cord-017772-zpf1xjqi 5 1 10.1007/978 10.1007/978 LS cord-017772-zpf1xjqi 5 2 - - SYM cord-017772-zpf1xjqi 5 3 3 3 CD cord-017772-zpf1xjqi 5 4 - - HYPH cord-017772-zpf1xjqi 5 5 030 030 CD cord-017772-zpf1xjqi 5 6 - - HYPH cord-017772-zpf1xjqi 5 7 26710 26710 CD cord-017772-zpf1xjqi 5 8 - - HYPH cord-017772-zpf1xjqi 5 9 0_83 0_83 CD cord-017772-zpf1xjqi 5 10 sha sha NNP cord-017772-zpf1xjqi 5 11 : : : cord-017772-zpf1xjqi 5 12 0ff4ee76f47e65ced1ef95794d2bf462b069caab 0ff4ee76f47e65ced1ef95794d2bf462b069caab CD cord-017772-zpf1xjqi 5 13 doc_id doc_id CD cord-017772-zpf1xjqi 5 14 : : : cord-017772-zpf1xjqi 5 15 17772 17772 CD cord-017772-zpf1xjqi 5 16 cord_uid cord_uid NNS cord-017772-zpf1xjqi 5 17 : : : cord-017772-zpf1xjqi 5 18 zpf1xjqi zpf1xjqi ADD cord-017772-zpf1xjqi 6 1 The the DT cord-017772-zpf1xjqi 6 2 evaluation evaluation NN cord-017772-zpf1xjqi 6 3 and and CC cord-017772-zpf1xjqi 6 4 management management NN cord-017772-zpf1xjqi 6 5 of of IN cord-017772-zpf1xjqi 6 6 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 6 7 is be VBZ cord-017772-zpf1xjqi 6 8 a a DT cord-017772-zpf1xjqi 6 9 daily daily JJ cord-017772-zpf1xjqi 6 10 challenge challenge NN cord-017772-zpf1xjqi 6 11 for for IN cord-017772-zpf1xjqi 6 12 clinicians clinician NNS cord-017772-zpf1xjqi 6 13 in in IN cord-017772-zpf1xjqi 6 14 the the DT cord-017772-zpf1xjqi 6 15 intensive intensive JJ cord-017772-zpf1xjqi 6 16 care care NN cord-017772-zpf1xjqi 6 17 unit unit NN cord-017772-zpf1xjqi 6 18 ( ( -LRB- cord-017772-zpf1xjqi 6 19 ICU ICU NNP cord-017772-zpf1xjqi 6 20 ) ) -RRB- cord-017772-zpf1xjqi 6 21 . . . cord-017772-zpf1xjqi 7 1 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 7 2 is be VBZ cord-017772-zpf1xjqi 7 3 incredibly incredibly RB cord-017772-zpf1xjqi 7 4 common common JJ cord-017772-zpf1xjqi 7 5 , , , cord-017772-zpf1xjqi 7 6 present present JJ cord-017772-zpf1xjqi 7 7 in in IN cord-017772-zpf1xjqi 7 8 upwards upwards RB cord-017772-zpf1xjqi 7 9 of of IN cord-017772-zpf1xjqi 7 10 60 60 CD cord-017772-zpf1xjqi 7 11 % % NN cord-017772-zpf1xjqi 7 12 of of IN cord-017772-zpf1xjqi 7 13 ICU ICU NNP cord-017772-zpf1xjqi 7 14 patients patient NNS cord-017772-zpf1xjqi 7 15 . . . cord-017772-zpf1xjqi 8 1 Additionally additionally RB cord-017772-zpf1xjqi 8 2 , , , cord-017772-zpf1xjqi 8 3 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 8 4 in in IN cord-017772-zpf1xjqi 8 5 the the DT cord-017772-zpf1xjqi 8 6 critically critically RB cord-017772-zpf1xjqi 8 7 ill ill JJ cord-017772-zpf1xjqi 8 8 is be VBZ cord-017772-zpf1xjqi 8 9 rarely rarely RB cord-017772-zpf1xjqi 8 10 caused cause VBN cord-017772-zpf1xjqi 8 11 by by IN cord-017772-zpf1xjqi 8 12 a a DT cord-017772-zpf1xjqi 8 13 single single JJ cord-017772-zpf1xjqi 8 14 etiology etiology NN cord-017772-zpf1xjqi 8 15 . . . cord-017772-zpf1xjqi 9 1 Several several JJ cord-017772-zpf1xjqi 9 2 causes cause NNS cord-017772-zpf1xjqi 9 3 of of IN cord-017772-zpf1xjqi 9 4 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 9 5 in in IN cord-017772-zpf1xjqi 9 6 the the DT cord-017772-zpf1xjqi 9 7 ICU ICU NNP cord-017772-zpf1xjqi 9 8 including include VBG cord-017772-zpf1xjqi 9 9 heparin heparin NN cord-017772-zpf1xjqi 9 10 - - HYPH cord-017772-zpf1xjqi 9 11 induced induce VBN cord-017772-zpf1xjqi 9 12 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 9 13 ( ( -LRB- cord-017772-zpf1xjqi 9 14 HIT hit VB cord-017772-zpf1xjqi 9 15 ) ) -RRB- cord-017772-zpf1xjqi 9 16 and and CC cord-017772-zpf1xjqi 9 17 thrombotic thrombotic JJ cord-017772-zpf1xjqi 9 18 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 9 19 purpura purpura NN cord-017772-zpf1xjqi 9 20 demand demand VBP cord-017772-zpf1xjqi 9 21 urgent urgent JJ cord-017772-zpf1xjqi 9 22 recognition recognition NN cord-017772-zpf1xjqi 9 23 and and CC cord-017772-zpf1xjqi 9 24 intervention intervention NN cord-017772-zpf1xjqi 9 25 . . . cord-017772-zpf1xjqi 10 1 This this DT cord-017772-zpf1xjqi 10 2 chapter chapter NN cord-017772-zpf1xjqi 10 3 provides provide VBZ cord-017772-zpf1xjqi 10 4 a a DT cord-017772-zpf1xjqi 10 5 general general JJ cord-017772-zpf1xjqi 10 6 overview overview NN cord-017772-zpf1xjqi 10 7 of of IN cord-017772-zpf1xjqi 10 8 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 10 9 in in IN cord-017772-zpf1xjqi 10 10 the the DT cord-017772-zpf1xjqi 10 11 ICU ICU NNP cord-017772-zpf1xjqi 10 12 and and CC cord-017772-zpf1xjqi 10 13 highlights highlight VBZ cord-017772-zpf1xjqi 10 14 important important JJ cord-017772-zpf1xjqi 10 15 diagnostic diagnostic JJ cord-017772-zpf1xjqi 10 16 and and CC cord-017772-zpf1xjqi 10 17 management management NN cord-017772-zpf1xjqi 10 18 considerations consideration NNS cord-017772-zpf1xjqi 10 19 for for IN cord-017772-zpf1xjqi 10 20 some some DT cord-017772-zpf1xjqi 10 21 of of IN cord-017772-zpf1xjqi 10 22 the the DT cord-017772-zpf1xjqi 10 23 most most RBS cord-017772-zpf1xjqi 10 24 common common JJ cord-017772-zpf1xjqi 10 25 etiologies etiology NNS cord-017772-zpf1xjqi 10 26 . . . cord-017772-zpf1xjqi 11 1 point point NN cord-017772-zpf1xjqi 11 2 during during IN cord-017772-zpf1xjqi 11 3 their -PRON- PRP$ cord-017772-zpf1xjqi 11 4 ICU ICU NNP cord-017772-zpf1xjqi 11 5 stay stay VBP cord-017772-zpf1xjqi 11 6 [ [ -LRB- cord-017772-zpf1xjqi 11 7 7 7 CD cord-017772-zpf1xjqi 11 8 , , , cord-017772-zpf1xjqi 11 9 8 8 CD cord-017772-zpf1xjqi 11 10 , , , cord-017772-zpf1xjqi 11 11 10 10 CD cord-017772-zpf1xjqi 11 12 , , , cord-017772-zpf1xjqi 11 13 11 11 CD cord-017772-zpf1xjqi 11 14 ] ] -RRB- cord-017772-zpf1xjqi 11 15 . . . cord-017772-zpf1xjqi 12 1 In in IN cord-017772-zpf1xjqi 12 2 general general JJ cord-017772-zpf1xjqi 12 3 , , , cord-017772-zpf1xjqi 12 4 ICU ICU NNP cord-017772-zpf1xjqi 12 5 patients patient NNS cord-017772-zpf1xjqi 12 6 who who WP cord-017772-zpf1xjqi 12 7 develop develop VBP cord-017772-zpf1xjqi 12 8 thrombocytopenia thrombocytopenia NNS cord-017772-zpf1xjqi 12 9 are be VBP cord-017772-zpf1xjqi 12 10 sicker sick JJR cord-017772-zpf1xjqi 12 11 than than IN cord-017772-zpf1xjqi 12 12 patients patient NNS cord-017772-zpf1xjqi 12 13 with with IN cord-017772-zpf1xjqi 12 14 normal normal JJ cord-017772-zpf1xjqi 12 15 platelet platelet NN cord-017772-zpf1xjqi 12 16 counts count NNS cord-017772-zpf1xjqi 12 17 , , , cord-017772-zpf1xjqi 12 18 with with IN cord-017772-zpf1xjqi 12 19 higher high JJR cord-017772-zpf1xjqi 12 20 illness illness NN cord-017772-zpf1xjqi 12 21 severity severity NN cord-017772-zpf1xjqi 12 22 scores score NNS cord-017772-zpf1xjqi 12 23 , , , cord-017772-zpf1xjqi 12 24 more more JJR cord-017772-zpf1xjqi 12 25 need need NN cord-017772-zpf1xjqi 12 26 for for IN cord-017772-zpf1xjqi 12 27 vasoactive vasoactive JJ cord-017772-zpf1xjqi 12 28 infusions infusion NNS cord-017772-zpf1xjqi 12 29 , , , cord-017772-zpf1xjqi 12 30 and and CC cord-017772-zpf1xjqi 12 31 more more JJR cord-017772-zpf1xjqi 12 32 organ organ NN cord-017772-zpf1xjqi 12 33 dysfunction dysfunction NN cord-017772-zpf1xjqi 12 34 [ [ -LRB- cord-017772-zpf1xjqi 12 35 8 8 CD cord-017772-zpf1xjqi 12 36 , , , cord-017772-zpf1xjqi 12 37 9 9 CD cord-017772-zpf1xjqi 12 38 ] ] -RRB- cord-017772-zpf1xjqi 12 39 . . . cord-017772-zpf1xjqi 13 1 The the DT cord-017772-zpf1xjqi 13 2 presence presence NN cord-017772-zpf1xjqi 13 3 of of IN cord-017772-zpf1xjqi 13 4 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 13 5 in in IN cord-017772-zpf1xjqi 13 6 the the DT cord-017772-zpf1xjqi 13 7 critically critically RB cord-017772-zpf1xjqi 13 8 ill ill JJ cord-017772-zpf1xjqi 13 9 has have VBZ cord-017772-zpf1xjqi 13 10 consistently consistently RB cord-017772-zpf1xjqi 13 11 been be VBN cord-017772-zpf1xjqi 13 12 associated associate VBN cord-017772-zpf1xjqi 13 13 with with IN cord-017772-zpf1xjqi 13 14 poor poor JJ cord-017772-zpf1xjqi 13 15 outcomes outcome NNS cord-017772-zpf1xjqi 13 16 . . . cord-017772-zpf1xjqi 14 1 In in IN cord-017772-zpf1xjqi 14 2 a a DT cord-017772-zpf1xjqi 14 3 multicenter multicenter JJ cord-017772-zpf1xjqi 14 4 review review NN cord-017772-zpf1xjqi 14 5 of of IN cord-017772-zpf1xjqi 14 6 over over IN cord-017772-zpf1xjqi 14 7 3000 3000 CD cord-017772-zpf1xjqi 14 8 critically critically RB cord-017772-zpf1xjqi 14 9 ill ill JJ cord-017772-zpf1xjqi 14 10 patients patient NNS cord-017772-zpf1xjqi 14 11 , , , cord-017772-zpf1xjqi 14 12 patients patient NNS cord-017772-zpf1xjqi 14 13 with with IN cord-017772-zpf1xjqi 14 14 severe severe JJ cord-017772-zpf1xjqi 14 15 thrombocytopenia thrombocytopenia NNS cord-017772-zpf1xjqi 14 16 ( ( -LRB- cord-017772-zpf1xjqi 14 17 defined define VBN cord-017772-zpf1xjqi 14 18 as as IN cord-017772-zpf1xjqi 14 19 a a DT cord-017772-zpf1xjqi 14 20 platelet platelet NN cord-017772-zpf1xjqi 14 21 count count NN cord-017772-zpf1xjqi 14 22 < < XX cord-017772-zpf1xjqi 14 23 50 50 CD cord-017772-zpf1xjqi 14 24 × × NN cord-017772-zpf1xjqi 14 25 10 10 CD cord-017772-zpf1xjqi 14 26 9 9 CD cord-017772-zpf1xjqi 14 27 cells cell NNS cord-017772-zpf1xjqi 14 28 / / SYM cord-017772-zpf1xjqi 14 29 L L NNP cord-017772-zpf1xjqi 14 30 ) ) -RRB- cord-017772-zpf1xjqi 14 31 had have VBD cord-017772-zpf1xjqi 14 32 an an DT cord-017772-zpf1xjqi 14 33 adjusted adjusted JJ cord-017772-zpf1xjqi 14 34 hazard hazard NN cord-017772-zpf1xjqi 14 35 ratio ratio NN cord-017772-zpf1xjqi 14 36 for for IN cord-017772-zpf1xjqi 14 37 hospital hospital NN cord-017772-zpf1xjqi 14 38 mortality mortality NN cord-017772-zpf1xjqi 14 39 of of IN cord-017772-zpf1xjqi 14 40 2.78 2.78 CD cord-017772-zpf1xjqi 14 41 ( ( -LRB- cord-017772-zpf1xjqi 14 42 95 95 CD cord-017772-zpf1xjqi 14 43 % % NN cord-017772-zpf1xjqi 14 44 CI CI NNP cord-017772-zpf1xjqi 14 45 , , , cord-017772-zpf1xjqi 14 46 2.20 2.20 CD cord-017772-zpf1xjqi 14 47 - - SYM cord-017772-zpf1xjqi 14 48 3.53 3.53 CD cord-017772-zpf1xjqi 14 49 ) ) -RRB- cord-017772-zpf1xjqi 14 50 compared compare VBN cord-017772-zpf1xjqi 14 51 to to IN cord-017772-zpf1xjqi 14 52 patients patient NNS cord-017772-zpf1xjqi 14 53 with with IN cord-017772-zpf1xjqi 14 54 normal normal JJ cord-017772-zpf1xjqi 14 55 platelet platelet NN cord-017772-zpf1xjqi 14 56 counts count NNS cord-017772-zpf1xjqi 14 57 [ [ -LRB- cord-017772-zpf1xjqi 14 58 8 8 CD cord-017772-zpf1xjqi 14 59 ] ] -RRB- cord-017772-zpf1xjqi 14 60 . . . cord-017772-zpf1xjqi 15 1 The the DT cord-017772-zpf1xjqi 15 2 association association NN cord-017772-zpf1xjqi 15 3 between between IN cord-017772-zpf1xjqi 15 4 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 15 5 and and CC cord-017772-zpf1xjqi 15 6 mortality mortality NN cord-017772-zpf1xjqi 15 7 has have VBZ cord-017772-zpf1xjqi 15 8 been be VBN cord-017772-zpf1xjqi 15 9 identified identify VBN cord-017772-zpf1xjqi 15 10 in in IN cord-017772-zpf1xjqi 15 11 multiple multiple JJ cord-017772-zpf1xjqi 15 12 studies study NNS cord-017772-zpf1xjqi 15 13 [ [ -LRB- cord-017772-zpf1xjqi 15 14 6 6 CD cord-017772-zpf1xjqi 15 15 , , , cord-017772-zpf1xjqi 15 16 9 9 CD cord-017772-zpf1xjqi 15 17 , , , cord-017772-zpf1xjqi 15 18 10 10 CD cord-017772-zpf1xjqi 15 19 , , , cord-017772-zpf1xjqi 15 20 12 12 CD cord-017772-zpf1xjqi 15 21 ] ] -RRB- cord-017772-zpf1xjqi 15 22 . . . cord-017772-zpf1xjqi 16 1 Regardless regardless RB cord-017772-zpf1xjqi 16 2 of of IN cord-017772-zpf1xjqi 16 3 the the DT cord-017772-zpf1xjqi 16 4 absolute absolute JJ cord-017772-zpf1xjqi 16 5 value value NN cord-017772-zpf1xjqi 16 6 , , , cord-017772-zpf1xjqi 16 7 a a DT cord-017772-zpf1xjqi 16 8 fall fall NN cord-017772-zpf1xjqi 16 9 in in IN cord-017772-zpf1xjqi 16 10 platelet platelet NN cord-017772-zpf1xjqi 16 11 count count NN cord-017772-zpf1xjqi 16 12 by by IN cord-017772-zpf1xjqi 16 13 > > XX cord-017772-zpf1xjqi 16 14 30 30 CD cord-017772-zpf1xjqi 16 15 % % NN cord-017772-zpf1xjqi 16 16 from from IN cord-017772-zpf1xjqi 16 17 a a DT cord-017772-zpf1xjqi 16 18 patient patient NN cord-017772-zpf1xjqi 16 19 's 's POS cord-017772-zpf1xjqi 16 20 admission admission NN cord-017772-zpf1xjqi 16 21 level level NN cord-017772-zpf1xjqi 16 22 identifies identify VBZ cord-017772-zpf1xjqi 16 23 patients patient NNS cord-017772-zpf1xjqi 16 24 who who WP cord-017772-zpf1xjqi 16 25 may may MD cord-017772-zpf1xjqi 16 26 be be VB cord-017772-zpf1xjqi 16 27 up up IN cord-017772-zpf1xjqi 16 28 to to TO cord-017772-zpf1xjqi 16 29 4 4 CD cord-017772-zpf1xjqi 16 30 times time NNS cord-017772-zpf1xjqi 16 31 more more RBR cord-017772-zpf1xjqi 16 32 likely likely JJ cord-017772-zpf1xjqi 16 33 to to TO cord-017772-zpf1xjqi 16 34 die die VB cord-017772-zpf1xjqi 16 35 during during IN cord-017772-zpf1xjqi 16 36 their -PRON- PRP$ cord-017772-zpf1xjqi 16 37 hospital hospital NN cord-017772-zpf1xjqi 16 38 stay stay NN cord-017772-zpf1xjqi 16 39 [ [ -LRB- cord-017772-zpf1xjqi 16 40 11 11 CD cord-017772-zpf1xjqi 16 41 , , , cord-017772-zpf1xjqi 16 42 13 13 CD cord-017772-zpf1xjqi 16 43 ] ] -RRB- cord-017772-zpf1xjqi 16 44 . . . cord-017772-zpf1xjqi 17 1 Patients patient NNS cord-017772-zpf1xjqi 17 2 whose whose WP$ cord-017772-zpf1xjqi 17 3 platelet platelet NN cord-017772-zpf1xjqi 17 4 count count NN cord-017772-zpf1xjqi 17 5 fails fail VBZ cord-017772-zpf1xjqi 17 6 to to TO cord-017772-zpf1xjqi 17 7 recover recover VB cord-017772-zpf1xjqi 17 8 during during IN cord-017772-zpf1xjqi 17 9 their -PRON- PRP$ cord-017772-zpf1xjqi 17 10 ICU ICU NNP cord-017772-zpf1xjqi 17 11 course course NN cord-017772-zpf1xjqi 17 12 represent represent VBP cord-017772-zpf1xjqi 17 13 a a DT cord-017772-zpf1xjqi 17 14 particularly particularly RB cord-017772-zpf1xjqi 17 15 high high JJ cord-017772-zpf1xjqi 17 16 risk risk NN cord-017772-zpf1xjqi 17 17 group group NN cord-017772-zpf1xjqi 17 18 [ [ -LRB- cord-017772-zpf1xjqi 17 19 6 6 CD cord-017772-zpf1xjqi 17 20 , , , cord-017772-zpf1xjqi 17 21 14 14 CD cord-017772-zpf1xjqi 17 22 ] ] -RRB- cord-017772-zpf1xjqi 17 23 . . . cord-017772-zpf1xjqi 18 1 The the DT cord-017772-zpf1xjqi 18 2 presence presence NN cord-017772-zpf1xjqi 18 3 and and CC cord-017772-zpf1xjqi 18 4 severity severity NN cord-017772-zpf1xjqi 18 5 of of IN cord-017772-zpf1xjqi 18 6 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 18 7 is be VBZ cord-017772-zpf1xjqi 18 8 included include VBN cord-017772-zpf1xjqi 18 9 in in IN cord-017772-zpf1xjqi 18 10 several several JJ cord-017772-zpf1xjqi 18 11 validated validate VBN cord-017772-zpf1xjqi 18 12 severity severity NN cord-017772-zpf1xjqi 18 13 scores score NNS cord-017772-zpf1xjqi 18 14 including include VBG cord-017772-zpf1xjqi 18 15 the the DT cord-017772-zpf1xjqi 18 16 Multiple Multiple NNP cord-017772-zpf1xjqi 18 17 Organ Organ NNP cord-017772-zpf1xjqi 18 18 Dysfunction Dysfunction NNP cord-017772-zpf1xjqi 18 19 Score Score NNP cord-017772-zpf1xjqi 18 20 and and CC cord-017772-zpf1xjqi 18 21 the the DT cord-017772-zpf1xjqi 18 22 Sepsis sepsis NN cord-017772-zpf1xjqi 18 23 - - HYPH cord-017772-zpf1xjqi 18 24 related relate VBN cord-017772-zpf1xjqi 18 25 Organ Organ NNP cord-017772-zpf1xjqi 18 26 Failure Failure NNP cord-017772-zpf1xjqi 18 27 Assessment Assessment NNP cord-017772-zpf1xjqi 18 28 [ [ -LRB- cord-017772-zpf1xjqi 18 29 15 15 CD cord-017772-zpf1xjqi 18 30 , , , cord-017772-zpf1xjqi 18 31 16 16 CD cord-017772-zpf1xjqi 18 32 ] ] -RRB- cord-017772-zpf1xjqi 18 33 . . . cord-017772-zpf1xjqi 19 1 The the DT cord-017772-zpf1xjqi 19 2 evaluation evaluation NN cord-017772-zpf1xjqi 19 3 of of IN cord-017772-zpf1xjqi 19 4 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 19 5 in in IN cord-017772-zpf1xjqi 19 6 the the DT cord-017772-zpf1xjqi 19 7 ICU ICU NNP cord-017772-zpf1xjqi 19 8 is be VBZ cord-017772-zpf1xjqi 19 9 challenging challenging JJ cord-017772-zpf1xjqi 19 10 as as IN cord-017772-zpf1xjqi 19 11 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 19 12 is be VBZ cord-017772-zpf1xjqi 19 13 both both CC cord-017772-zpf1xjqi 19 14 a a DT cord-017772-zpf1xjqi 19 15 common common JJ cord-017772-zpf1xjqi 19 16 problem problem NN cord-017772-zpf1xjqi 19 17 and and CC cord-017772-zpf1xjqi 19 18 rarely rarely RB cord-017772-zpf1xjqi 19 19 due due JJ cord-017772-zpf1xjqi 19 20 to to IN cord-017772-zpf1xjqi 19 21 a a DT cord-017772-zpf1xjqi 19 22 single single JJ cord-017772-zpf1xjqi 19 23 etiology etiology NN cord-017772-zpf1xjqi 19 24 . . . cord-017772-zpf1xjqi 20 1 In in IN cord-017772-zpf1xjqi 20 2 a a DT cord-017772-zpf1xjqi 20 3 study study NN cord-017772-zpf1xjqi 20 4 of of IN cord-017772-zpf1xjqi 20 5 over over IN cord-017772-zpf1xjqi 20 6 300 300 CD cord-017772-zpf1xjqi 20 7 ICU ICU NNP cord-017772-zpf1xjqi 20 8 patients patient NNS cord-017772-zpf1xjqi 20 9 with with IN cord-017772-zpf1xjqi 20 10 either either CC cord-017772-zpf1xjqi 20 11 absolute absolute JJ cord-017772-zpf1xjqi 20 12 ( ( -LRB- cord-017772-zpf1xjqi 20 13 platelet platelet NN cord-017772-zpf1xjqi 20 14 count count NN cord-017772-zpf1xjqi 20 15 < < XX cord-017772-zpf1xjqi 20 16 100 100 CD cord-017772-zpf1xjqi 20 17 × × NN cord-017772-zpf1xjqi 20 18 10 10 CD cord-017772-zpf1xjqi 20 19 9 9 CD cord-017772-zpf1xjqi 20 20 cells cell NNS cord-017772-zpf1xjqi 20 21 / / SYM cord-017772-zpf1xjqi 20 22 L l NN cord-017772-zpf1xjqi 20 23 ) ) -RRB- cord-017772-zpf1xjqi 20 24 or or CC cord-017772-zpf1xjqi 20 25 relative relative JJ cord-017772-zpf1xjqi 20 26 ( ( -LRB- cord-017772-zpf1xjqi 20 27 decrease decrease NN cord-017772-zpf1xjqi 20 28 in in IN cord-017772-zpf1xjqi 20 29 platelet platelet NN cord-017772-zpf1xjqi 20 30 count count NN cord-017772-zpf1xjqi 20 31 > > XX cord-017772-zpf1xjqi 20 32 30 30 CD cord-017772-zpf1xjqi 20 33 % % NN cord-017772-zpf1xjqi 20 34 ) ) -RRB- cord-017772-zpf1xjqi 20 35 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 20 36 who who WP cord-017772-zpf1xjqi 20 37 underwent undergo VBD cord-017772-zpf1xjqi 20 38 extensive extensive JJ cord-017772-zpf1xjqi 20 39 evaluation evaluation NN cord-017772-zpf1xjqi 20 40 including include VBG cord-017772-zpf1xjqi 20 41 bone bone NN cord-017772-zpf1xjqi 20 42 marrow marrow NN cord-017772-zpf1xjqi 20 43 aspiration aspiration NN cord-017772-zpf1xjqi 20 44 , , , cord-017772-zpf1xjqi 20 45 37 37 CD cord-017772-zpf1xjqi 20 46 % % NN cord-017772-zpf1xjqi 20 47 had have VBD cord-017772-zpf1xjqi 20 48 3 3 CD cord-017772-zpf1xjqi 20 49 or or CC cord-017772-zpf1xjqi 20 50 more more RBR cord-017772-zpf1xjqi 20 51 identifiable identifiable JJ cord-017772-zpf1xjqi 20 52 etiologies etiology NNS cord-017772-zpf1xjqi 20 53 for for IN cord-017772-zpf1xjqi 20 54 their -PRON- PRP$ cord-017772-zpf1xjqi 20 55 thrombocytopenia thrombocytopenia NNS cord-017772-zpf1xjqi 20 56 [ [ -LRB- cord-017772-zpf1xjqi 20 57 17 17 CD cord-017772-zpf1xjqi 20 58 ] ] -RRB- cord-017772-zpf1xjqi 20 59 . . . cord-017772-zpf1xjqi 21 1 As as IN cord-017772-zpf1xjqi 21 2 such such JJ cord-017772-zpf1xjqi 21 3 , , , cord-017772-zpf1xjqi 21 4 a a DT cord-017772-zpf1xjqi 21 5 structured structured JJ cord-017772-zpf1xjqi 21 6 approach approach NN cord-017772-zpf1xjqi 21 7 to to IN cord-017772-zpf1xjqi 21 8 the the DT cord-017772-zpf1xjqi 21 9 evaluation evaluation NN cord-017772-zpf1xjqi 21 10 and and CC cord-017772-zpf1xjqi 21 11 management management NN cord-017772-zpf1xjqi 21 12 of of IN cord-017772-zpf1xjqi 21 13 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 21 14 is be VBZ cord-017772-zpf1xjqi 21 15 essential essential JJ cord-017772-zpf1xjqi 21 16 . . . cord-017772-zpf1xjqi 22 1 A a DT cord-017772-zpf1xjqi 22 2 comprehensive comprehensive JJ cord-017772-zpf1xjqi 22 3 review review NN cord-017772-zpf1xjqi 22 4 of of IN cord-017772-zpf1xjqi 22 5 the the DT cord-017772-zpf1xjqi 22 6 myriad myriad JJ cord-017772-zpf1xjqi 22 7 causes cause NNS cord-017772-zpf1xjqi 22 8 of of IN cord-017772-zpf1xjqi 22 9 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 22 10 is be VBZ cord-017772-zpf1xjqi 22 11 beyond beyond IN cord-017772-zpf1xjqi 22 12 the the DT cord-017772-zpf1xjqi 22 13 scope scope NN cord-017772-zpf1xjqi 22 14 of of IN cord-017772-zpf1xjqi 22 15 this this DT cord-017772-zpf1xjqi 22 16 review review NN cord-017772-zpf1xjqi 22 17 . . . cord-017772-zpf1xjqi 23 1 What what WP cord-017772-zpf1xjqi 23 2 follows follow VBZ cord-017772-zpf1xjqi 23 3 is be VBZ cord-017772-zpf1xjqi 23 4 a a DT cord-017772-zpf1xjqi 23 5 simplified simplified JJ cord-017772-zpf1xjqi 23 6 approach approach NN cord-017772-zpf1xjqi 23 7 to to IN cord-017772-zpf1xjqi 23 8 the the DT cord-017772-zpf1xjqi 23 9 critically critically RB cord-017772-zpf1xjqi 23 10 ill ill JJ cord-017772-zpf1xjqi 23 11 patient patient NN cord-017772-zpf1xjqi 23 12 with with IN cord-017772-zpf1xjqi 23 13 newonset newonset NNP cord-017772-zpf1xjqi 23 14 thrombocytopenia thrombocytopenia NNP cord-017772-zpf1xjqi 24 1 ( ( -LRB- cord-017772-zpf1xjqi 24 2 Fig Fig NNP cord-017772-zpf1xjqi 24 3 . . . cord-017772-zpf1xjqi 24 4 83.1 83.1 CD cord-017772-zpf1xjqi 24 5 ) ) -RRB- cord-017772-zpf1xjqi 24 6 . . . cord-017772-zpf1xjqi 25 1 Step step NN cord-017772-zpf1xjqi 25 2 1 1 CD cord-017772-zpf1xjqi 25 3 : : : cord-017772-zpf1xjqi 25 4 Confirm confirm VB cord-017772-zpf1xjqi 25 5 True true JJ cord-017772-zpf1xjqi 25 6 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 25 7 Pseudothrombocytopenia Pseudothrombocytopenia NNP cord-017772-zpf1xjqi 26 1 Occasionally occasionally RB cord-017772-zpf1xjqi 26 2 , , , cord-017772-zpf1xjqi 26 3 a a DT cord-017772-zpf1xjqi 26 4 low low JJ cord-017772-zpf1xjqi 26 5 reported reported JJ cord-017772-zpf1xjqi 26 6 platelet platelet NN cord-017772-zpf1xjqi 26 7 count count NN cord-017772-zpf1xjqi 26 8 does do VBZ cord-017772-zpf1xjqi 26 9 not not RB cord-017772-zpf1xjqi 26 10 represent represent VB cord-017772-zpf1xjqi 26 11 true true JJ cord-017772-zpf1xjqi 26 12 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 26 13 . . . cord-017772-zpf1xjqi 27 1 Exposure exposure NN cord-017772-zpf1xjqi 27 2 to to IN cord-017772-zpf1xjqi 27 3 ethylenediaminetetraacetic ethylenediaminetetraacetic JJ cord-017772-zpf1xjqi 27 4 acid acid NN cord-017772-zpf1xjqi 27 5 ( ( -LRB- cord-017772-zpf1xjqi 27 6 EDTA EDTA NNP cord-017772-zpf1xjqi 27 7 ) ) -RRB- cord-017772-zpf1xjqi 27 8 in in IN cord-017772-zpf1xjqi 27 9 blood blood NN cord-017772-zpf1xjqi 27 10 collection collection NN cord-017772-zpf1xjqi 27 11 tubes tube NNS cord-017772-zpf1xjqi 27 12 induces induce VBZ cord-017772-zpf1xjqi 27 13 a a DT cord-017772-zpf1xjqi 27 14 conformational conformational JJ cord-017772-zpf1xjqi 27 15 change change NN cord-017772-zpf1xjqi 27 16 in in IN cord-017772-zpf1xjqi 27 17 the the DT cord-017772-zpf1xjqi 27 18 platelet platelet NN cord-017772-zpf1xjqi 27 19 surface surface NN cord-017772-zpf1xjqi 27 20 protein protein NN cord-017772-zpf1xjqi 27 21 glycoprotein glycoprotein NN cord-017772-zpf1xjqi 27 22 IIb IIb NNP cord-017772-zpf1xjqi 27 23 / / SYM cord-017772-zpf1xjqi 27 24 IIIa IIIa NNS cord-017772-zpf1xjqi 27 25 [ [ -LRB- cord-017772-zpf1xjqi 27 26 18 18 CD cord-017772-zpf1xjqi 27 27 ] ] -RRB- cord-017772-zpf1xjqi 27 28 . . . cord-017772-zpf1xjqi 28 1 Patients patient NNS cord-017772-zpf1xjqi 28 2 may may MD cord-017772-zpf1xjqi 28 3 develop develop VB cord-017772-zpf1xjqi 28 4 IgM IgM NNP cord-017772-zpf1xjqi 28 5 autoantibodies autoantibody NNS cord-017772-zpf1xjqi 28 6 to to IN cord-017772-zpf1xjqi 28 7 these these DT cord-017772-zpf1xjqi 28 8 newly newly RB cord-017772-zpf1xjqi 28 9 exposed expose VBN cord-017772-zpf1xjqi 28 10 GIIb GIIb NNS cord-017772-zpf1xjqi 28 11 / / SYM cord-017772-zpf1xjqi 28 12 IIIa IIIa NNP cord-017772-zpf1xjqi 28 13 epitopes epitope NNS cord-017772-zpf1xjqi 28 14 which which WDT cord-017772-zpf1xjqi 28 15 causes cause VBZ cord-017772-zpf1xjqi 28 16 in in IN cord-017772-zpf1xjqi 28 17 vitro vitro FW cord-017772-zpf1xjqi 28 18 platelet platelet NN cord-017772-zpf1xjqi 28 19 clumping clumping NN cord-017772-zpf1xjqi 28 20 . . . cord-017772-zpf1xjqi 29 1 Large large JJ cord-017772-zpf1xjqi 29 2 platelet platelet NN cord-017772-zpf1xjqi 29 3 aggregates aggregate NNS cord-017772-zpf1xjqi 29 4 are be VBP cord-017772-zpf1xjqi 29 5 not not RB cord-017772-zpf1xjqi 29 6 recognized recognize VBN cord-017772-zpf1xjqi 29 7 by by IN cord-017772-zpf1xjqi 29 8 automated automate VBN cord-017772-zpf1xjqi 29 9 counters counter NNS cord-017772-zpf1xjqi 29 10 , , , cord-017772-zpf1xjqi 29 11 leading lead VBG cord-017772-zpf1xjqi 29 12 to to IN cord-017772-zpf1xjqi 29 13 a a DT cord-017772-zpf1xjqi 29 14 falsely falsely RB cord-017772-zpf1xjqi 29 15 low low JJ cord-017772-zpf1xjqi 29 16 reported reported JJ cord-017772-zpf1xjqi 29 17 platelet platelet NN cord-017772-zpf1xjqi 29 18 count count NN cord-017772-zpf1xjqi 29 19 . . . cord-017772-zpf1xjqi 30 1 The the DT cord-017772-zpf1xjqi 30 2 identification identification NN cord-017772-zpf1xjqi 30 3 of of IN cord-017772-zpf1xjqi 30 4 platelet platelet NN cord-017772-zpf1xjqi 30 5 clumps clump NNS cord-017772-zpf1xjqi 30 6 on on IN cord-017772-zpf1xjqi 30 7 a a DT cord-017772-zpf1xjqi 30 8 peripheral peripheral JJ cord-017772-zpf1xjqi 30 9 blood blood NN cord-017772-zpf1xjqi 30 10 smear smear NN cord-017772-zpf1xjqi 30 11 and and CC cord-017772-zpf1xjqi 30 12 re re JJ cord-017772-zpf1xjqi 30 13 - - JJ cord-017772-zpf1xjqi 30 14 drawing draw VBG cord-017772-zpf1xjqi 30 15 blood blood NN cord-017772-zpf1xjqi 30 16 using use VBG cord-017772-zpf1xjqi 30 17 heparin heparin NN cord-017772-zpf1xjqi 30 18 or or CC cord-017772-zpf1xjqi 30 19 citrate citrate NN cord-017772-zpf1xjqi 30 20 containing contain VBG cord-017772-zpf1xjqi 30 21 collection collection NN cord-017772-zpf1xjqi 30 22 tubes tube NNS cord-017772-zpf1xjqi 30 23 can can MD cord-017772-zpf1xjqi 30 24 help help VB cord-017772-zpf1xjqi 30 25 confirm confirm VB cord-017772-zpf1xjqi 30 26 the the DT cord-017772-zpf1xjqi 30 27 diagnosis diagnosis NN cord-017772-zpf1xjqi 30 28 . . . cord-017772-zpf1xjqi 31 1 Step step NN cord-017772-zpf1xjqi 31 2 2 2 CD cord-017772-zpf1xjqi 31 3 : : : cord-017772-zpf1xjqi 31 4 Is be VBZ cord-017772-zpf1xjqi 31 5 the the DT cord-017772-zpf1xjqi 31 6 Patient Patient NNP cord-017772-zpf1xjqi 31 7 Bleeding bleed VBG cord-017772-zpf1xjqi 31 8 ? ? . cord-017772-zpf1xjqi 32 1 There there EX cord-017772-zpf1xjqi 32 2 is be VBZ cord-017772-zpf1xjqi 32 3 a a DT cord-017772-zpf1xjqi 32 4 consensus consensus NN cord-017772-zpf1xjqi 32 5 that that WDT cord-017772-zpf1xjqi 32 6 patients patient NNS cord-017772-zpf1xjqi 32 7 with with IN cord-017772-zpf1xjqi 32 8 clinically clinically RB cord-017772-zpf1xjqi 32 9 significant significant JJ cord-017772-zpf1xjqi 32 10 bleeding bleeding NN cord-017772-zpf1xjqi 32 11 should should MD cord-017772-zpf1xjqi 32 12 be be VB cord-017772-zpf1xjqi 32 13 transfused transfuse VBN cord-017772-zpf1xjqi 32 14 to to IN cord-017772-zpf1xjqi 32 15 a a DT cord-017772-zpf1xjqi 32 16 platelet platelet NN cord-017772-zpf1xjqi 32 17 count count NN cord-017772-zpf1xjqi 32 18 of of IN cord-017772-zpf1xjqi 32 19 > > $ cord-017772-zpf1xjqi 32 20 50 50 CD cord-017772-zpf1xjqi 32 21 × × NN cord-017772-zpf1xjqi 32 22 10 10 CD cord-017772-zpf1xjqi 32 23 9 9 CD cord-017772-zpf1xjqi 32 24 • • NNS cord-017772-zpf1xjqi 33 1 If if IN cord-017772-zpf1xjqi 33 2 platelet platelet NN cord-017772-zpf1xjqi 33 3 clumps clump NNS cord-017772-zpf1xjqi 33 4 seen see VBN cord-017772-zpf1xjqi 33 5 on on IN cord-017772-zpf1xjqi 33 6 smear smear NN cord-017772-zpf1xjqi 33 7 , , , cord-017772-zpf1xjqi 33 8 repeat repeat VB cord-017772-zpf1xjqi 33 9 blood blood NN cord-017772-zpf1xjqi 33 10 draw draw VBP cord-017772-zpf1xjqi 33 11 in in IN cord-017772-zpf1xjqi 33 12 non non JJ cord-017772-zpf1xjqi 33 13 - - JJ cord-017772-zpf1xjqi 33 14 EDTA edta JJ cord-017772-zpf1xjqi 33 15 collection collection NN cord-017772-zpf1xjqi 33 16 tube tube NN cord-017772-zpf1xjqi 34 1 • • NNP cord-017772-zpf1xjqi 35 1 Platelet platelet NN cord-017772-zpf1xjqi 35 2 goal goal NN cord-017772-zpf1xjqi 36 1 > > XX cord-017772-zpf1xjqi 37 1 50 50 CD cord-017772-zpf1xjqi 37 2 x x SYM cord-017772-zpf1xjqi 37 3 10 10 CD cord-017772-zpf1xjqi 37 4 9 9 CD cord-017772-zpf1xjqi 37 5 cells cell NNS cord-017772-zpf1xjqi 37 6 / / SYM cord-017772-zpf1xjqi 37 7 L l NN cord-017772-zpf1xjqi 37 8 in in IN cord-017772-zpf1xjqi 37 9 non non JJ cord-017772-zpf1xjqi 37 10 - - JJ cord-017772-zpf1xjqi 37 11 CNS cns JJ cord-017772-zpf1xjqi 37 12 bleeding bleed VBG cord-017772-zpf1xjqi 37 13 [ [ -LRB- cord-017772-zpf1xjqi 37 14 4 4 CD cord-017772-zpf1xjqi 37 15 , , , cord-017772-zpf1xjqi 37 16 19 19 CD cord-017772-zpf1xjqi 37 17 , , , cord-017772-zpf1xjqi 37 18 20 20 CD cord-017772-zpf1xjqi 37 19 ] ] -RRB- cord-017772-zpf1xjqi 38 1 The the DT cord-017772-zpf1xjqi 38 2 transfusion transfusion NN cord-017772-zpf1xjqi 38 3 threshold threshold NN cord-017772-zpf1xjqi 38 4 should should MD cord-017772-zpf1xjqi 38 5 be be VB cord-017772-zpf1xjqi 38 6 increased increase VBN cord-017772-zpf1xjqi 38 7 to to IN cord-017772-zpf1xjqi 38 8 100 100 CD cord-017772-zpf1xjqi 38 9 × × NN cord-017772-zpf1xjqi 38 10 10 10 CD cord-017772-zpf1xjqi 38 11 9 9 CD cord-017772-zpf1xjqi 38 12 cells cell NNS cord-017772-zpf1xjqi 38 13 / / SYM cord-017772-zpf1xjqi 38 14 L l NN cord-017772-zpf1xjqi 38 15 in in IN cord-017772-zpf1xjqi 38 16 patients patient NNS cord-017772-zpf1xjqi 38 17 with with IN cord-017772-zpf1xjqi 38 18 intracranial intracranial JJ cord-017772-zpf1xjqi 38 19 bleeding bleed VBG cord-017772-zpf1xjqi 38 20 [ [ -LRB- cord-017772-zpf1xjqi 38 21 21 21 CD cord-017772-zpf1xjqi 38 22 ] ] -RRB- cord-017772-zpf1xjqi 38 23 . . . cord-017772-zpf1xjqi 39 1 Thrombotic thrombotic JJ cord-017772-zpf1xjqi 39 2 microangiopathy microangiopathy NN cord-017772-zpf1xjqi 39 3 ( ( -LRB- cord-017772-zpf1xjqi 39 4 TMA TMA NNP cord-017772-zpf1xjqi 39 5 ) ) -RRB- cord-017772-zpf1xjqi 39 6 is be VBZ cord-017772-zpf1xjqi 39 7 a a DT cord-017772-zpf1xjqi 39 8 pathologic pathologic JJ cord-017772-zpf1xjqi 39 9 term term NN cord-017772-zpf1xjqi 39 10 used use VBN cord-017772-zpf1xjqi 39 11 to to TO cord-017772-zpf1xjqi 39 12 describe describe VB cord-017772-zpf1xjqi 39 13 microvascular microvascular JJ cord-017772-zpf1xjqi 39 14 thrombosis thrombosis NN cord-017772-zpf1xjqi 39 15 in in IN cord-017772-zpf1xjqi 39 16 the the DT cord-017772-zpf1xjqi 39 17 arterioles arteriole NNS cord-017772-zpf1xjqi 39 18 and and CC cord-017772-zpf1xjqi 39 19 capillaries capillary NNS cord-017772-zpf1xjqi 39 20 [ [ -LRB- cord-017772-zpf1xjqi 39 21 22 22 CD cord-017772-zpf1xjqi 39 22 ] ] -RRB- cord-017772-zpf1xjqi 39 23 . . . cord-017772-zpf1xjqi 40 1 The the DT cord-017772-zpf1xjqi 40 2 key key JJ cord-017772-zpf1xjqi 40 3 clinical clinical JJ cord-017772-zpf1xjqi 40 4 manifestations manifestation NNS cord-017772-zpf1xjqi 40 5 of of IN cord-017772-zpf1xjqi 40 6 TMAs TMAs NNP cord-017772-zpf1xjqi 40 7 are be VBP cord-017772-zpf1xjqi 40 8 microangiopathic microangiopathic JJ cord-017772-zpf1xjqi 40 9 hemolytic hemolytic JJ cord-017772-zpf1xjqi 40 10 anemia anemia NN cord-017772-zpf1xjqi 40 11 ( ( -LRB- cord-017772-zpf1xjqi 40 12 MAHA MAHA NNP cord-017772-zpf1xjqi 40 13 ) ) -RRB- cord-017772-zpf1xjqi 40 14 and and CC cord-017772-zpf1xjqi 40 15 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 40 16 . . . cord-017772-zpf1xjqi 41 1 TMAs TMAs NNP cord-017772-zpf1xjqi 41 2 are be VBP cord-017772-zpf1xjqi 41 3 a a DT cord-017772-zpf1xjqi 41 4 diverse diverse JJ cord-017772-zpf1xjqi 41 5 group group NN cord-017772-zpf1xjqi 41 6 of of IN cord-017772-zpf1xjqi 41 7 disorders disorder NNS cord-017772-zpf1xjqi 41 8 that that WDT cord-017772-zpf1xjqi 41 9 can can MD cord-017772-zpf1xjqi 41 10 be be VB cord-017772-zpf1xjqi 41 11 classified classify VBN cord-017772-zpf1xjqi 41 12 broadly broadly RB cord-017772-zpf1xjqi 41 13 as as IN cord-017772-zpf1xjqi 41 14 primary primary JJ cord-017772-zpf1xjqi 41 15 ( ( -LRB- cord-017772-zpf1xjqi 41 16 thrombotic thrombotic JJ cord-017772-zpf1xjqi 41 17 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 41 18 purpura purpura NN cord-017772-zpf1xjqi 41 19 , , , cord-017772-zpf1xjqi 41 20 hemolytic hemolytic JJ cord-017772-zpf1xjqi 41 21 uremic uremic JJ cord-017772-zpf1xjqi 41 22 syndrome syndrome NN cord-017772-zpf1xjqi 41 23 , , , cord-017772-zpf1xjqi 41 24 drug drug NN cord-017772-zpf1xjqi 41 25 - - HYPH cord-017772-zpf1xjqi 41 26 mediated mediate VBN cord-017772-zpf1xjqi 41 27 , , , cord-017772-zpf1xjqi 41 28 etc etc FW cord-017772-zpf1xjqi 41 29 . . . cord-017772-zpf1xjqi 41 30 ) ) -RRB- cord-017772-zpf1xjqi 41 31 or or CC cord-017772-zpf1xjqi 41 32 secondary secondary JJ cord-017772-zpf1xjqi 41 33 to to IN cord-017772-zpf1xjqi 41 34 a a DT cord-017772-zpf1xjqi 41 35 systemic systemic JJ cord-017772-zpf1xjqi 41 36 disorder disorder NN cord-017772-zpf1xjqi 41 37 ( ( -LRB- cord-017772-zpf1xjqi 41 38 disseminated disseminate VBN cord-017772-zpf1xjqi 41 39 intravascular intravascular JJ cord-017772-zpf1xjqi 41 40 coagulation coagulation NN cord-017772-zpf1xjqi 41 41 , , , cord-017772-zpf1xjqi 41 42 severe severe JJ cord-017772-zpf1xjqi 41 43 hypertension hypertension NN cord-017772-zpf1xjqi 41 44 , , , cord-017772-zpf1xjqi 41 45 hemolysis hemolysis NN cord-017772-zpf1xjqi 41 46 with with IN cord-017772-zpf1xjqi 41 47 elevated elevated JJ cord-017772-zpf1xjqi 41 48 liver liver NN cord-017772-zpf1xjqi 41 49 enzymes enzyme NNS cord-017772-zpf1xjqi 41 50 and and CC cord-017772-zpf1xjqi 41 51 low low JJ cord-017772-zpf1xjqi 41 52 platelets platelet NNS cord-017772-zpf1xjqi 41 53 during during IN cord-017772-zpf1xjqi 41 54 pregnancy pregnancy NN cord-017772-zpf1xjqi 41 55 , , , cord-017772-zpf1xjqi 41 56 etc etc FW cord-017772-zpf1xjqi 41 57 . . . cord-017772-zpf1xjqi 41 58 ) ) -RRB- cord-017772-zpf1xjqi 42 1 [ [ -LRB- cord-017772-zpf1xjqi 42 2 23 23 CD cord-017772-zpf1xjqi 42 3 ] ] -RRB- cord-017772-zpf1xjqi 42 4 . . . cord-017772-zpf1xjqi 43 1 While while IN cord-017772-zpf1xjqi 43 2 diseases disease NNS cord-017772-zpf1xjqi 43 3 like like IN cord-017772-zpf1xjqi 43 4 thrombotic thrombotic JJ cord-017772-zpf1xjqi 43 5 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 43 6 purpura purpura NN cord-017772-zpf1xjqi 43 7 ( ( -LRB- cord-017772-zpf1xjqi 43 8 TTP TTP NNP cord-017772-zpf1xjqi 43 9 ) ) -RRB- cord-017772-zpf1xjqi 43 10 are be VBP cord-017772-zpf1xjqi 43 11 uncommon uncommon JJ cord-017772-zpf1xjqi 43 12 , , , cord-017772-zpf1xjqi 43 13 their -PRON- PRP$ cord-017772-zpf1xjqi 43 14 prompt prompt JJ cord-017772-zpf1xjqi 43 15 recognition recognition NN cord-017772-zpf1xjqi 43 16 is be VBZ cord-017772-zpf1xjqi 43 17 critical critical JJ cord-017772-zpf1xjqi 43 18 as as IN cord-017772-zpf1xjqi 43 19 delayed delay VBN cord-017772-zpf1xjqi 43 20 or or CC cord-017772-zpf1xjqi 43 21 missed miss VBN cord-017772-zpf1xjqi 43 22 diagnosis diagnosis NN cord-017772-zpf1xjqi 43 23 can can MD cord-017772-zpf1xjqi 43 24 lead lead VB cord-017772-zpf1xjqi 43 25 to to IN cord-017772-zpf1xjqi 43 26 significant significant JJ cord-017772-zpf1xjqi 43 27 patient patient JJ cord-017772-zpf1xjqi 43 28 harm harm NN cord-017772-zpf1xjqi 43 29 . . . cord-017772-zpf1xjqi 44 1 TTP TTP NNP cord-017772-zpf1xjqi 44 2 and and CC cord-017772-zpf1xjqi 44 3 disseminated disseminate VBN cord-017772-zpf1xjqi 44 4 intravascular intravascular JJ cord-017772-zpf1xjqi 44 5 coagulation coagulation NN cord-017772-zpf1xjqi 44 6 ( ( -LRB- cord-017772-zpf1xjqi 44 7 DIC DIC NNP cord-017772-zpf1xjqi 44 8 ) ) -RRB- cord-017772-zpf1xjqi 44 9 will will MD cord-017772-zpf1xjqi 44 10 be be VB cord-017772-zpf1xjqi 44 11 reviewed review VBN cord-017772-zpf1xjqi 44 12 here here RB cord-017772-zpf1xjqi 44 13 as as IN cord-017772-zpf1xjqi 44 14 examples example NNS cord-017772-zpf1xjqi 44 15 of of IN cord-017772-zpf1xjqi 44 16 primary primary JJ cord-017772-zpf1xjqi 44 17 and and CC cord-017772-zpf1xjqi 44 18 secondary secondary JJ cord-017772-zpf1xjqi 44 19 TMAs tmas NN cord-017772-zpf1xjqi 44 20 respectively respectively RB cord-017772-zpf1xjqi 44 21 . . . cord-017772-zpf1xjqi 45 1 TTP TTP NNP cord-017772-zpf1xjqi 45 2 is be VBZ cord-017772-zpf1xjqi 45 3 characterized characterize VBN cord-017772-zpf1xjqi 45 4 by by IN cord-017772-zpf1xjqi 45 5 a a DT cord-017772-zpf1xjqi 45 6 functional functional JJ cord-017772-zpf1xjqi 45 7 deficiency deficiency NN cord-017772-zpf1xjqi 45 8 in in IN cord-017772-zpf1xjqi 45 9 a a DT cord-017772-zpf1xjqi 45 10 VWF VWF NNP cord-017772-zpf1xjqi 45 11 cleaving cleave VBG cord-017772-zpf1xjqi 45 12 protein protein NN cord-017772-zpf1xjqi 45 13 termed term VBN cord-017772-zpf1xjqi 45 14 , , , cord-017772-zpf1xjqi 45 15 " " '' cord-017772-zpf1xjqi 45 16 an an DT cord-017772-zpf1xjqi 45 17 acronym acronym NN cord-017772-zpf1xjqi 45 18 for for IN cord-017772-zpf1xjqi 45 19 a a DT cord-017772-zpf1xjqi 45 20 disintegrin disintegrin NNP cord-017772-zpf1xjqi 45 21 and and CC cord-017772-zpf1xjqi 45 22 metalloprotease metalloprotease NN cord-017772-zpf1xjqi 45 23 with with IN cord-017772-zpf1xjqi 45 24 thrombospondin-1-like thrombospondin-1-like NN cord-017772-zpf1xjqi 45 25 - - HYPH cord-017772-zpf1xjqi 45 26 domains domain NNS cord-017772-zpf1xjqi 45 27 " " '' cord-017772-zpf1xjqi 45 28 ( ( -LRB- cord-017772-zpf1xjqi 45 29 ADAMTS ADAMTS NNP cord-017772-zpf1xjqi 45 30 13 13 CD cord-017772-zpf1xjqi 45 31 ) ) -RRB- cord-017772-zpf1xjqi 45 32 [ [ -LRB- cord-017772-zpf1xjqi 45 33 24 24 CD cord-017772-zpf1xjqi 45 34 ] ] -RRB- cord-017772-zpf1xjqi 45 35 . . . cord-017772-zpf1xjqi 46 1 With with IN cord-017772-zpf1xjqi 46 2 a a DT cord-017772-zpf1xjqi 46 3 functional functional JJ cord-017772-zpf1xjqi 46 4 deficiency deficiency NN cord-017772-zpf1xjqi 46 5 of of IN cord-017772-zpf1xjqi 46 6 ADAMTS ADAMTS NNP cord-017772-zpf1xjqi 46 7 13 13 CD cord-017772-zpf1xjqi 46 8 , , , cord-017772-zpf1xjqi 46 9 large large JJ cord-017772-zpf1xjqi 46 10 VWF VWF NNP cord-017772-zpf1xjqi 46 11 multimers multimer NNS cord-017772-zpf1xjqi 46 12 accumulate accumulate VBP cord-017772-zpf1xjqi 46 13 , , , cord-017772-zpf1xjqi 46 14 triggering trigger VBG cord-017772-zpf1xjqi 46 15 platelet platelet NN cord-017772-zpf1xjqi 46 16 adhesion adhesion NN cord-017772-zpf1xjqi 46 17 , , , cord-017772-zpf1xjqi 46 18 activation activation NN cord-017772-zpf1xjqi 46 19 , , , cord-017772-zpf1xjqi 46 20 and and CC cord-017772-zpf1xjqi 46 21 the the DT cord-017772-zpf1xjqi 46 22 formation formation NN cord-017772-zpf1xjqi 46 23 of of IN cord-017772-zpf1xjqi 46 24 platelet platelet NN cord-017772-zpf1xjqi 46 25 rich rich JJ cord-017772-zpf1xjqi 46 26 microthrombi microthrombi NN cord-017772-zpf1xjqi 46 27 [ [ -LRB- cord-017772-zpf1xjqi 46 28 25 25 CD cord-017772-zpf1xjqi 46 29 ] ] -RRB- cord-017772-zpf1xjqi 46 30 . . . cord-017772-zpf1xjqi 47 1 TTP TTP NNP cord-017772-zpf1xjqi 47 2 is be VBZ cord-017772-zpf1xjqi 47 3 a a DT cord-017772-zpf1xjqi 47 4 rare rare JJ cord-017772-zpf1xjqi 47 5 disease disease NN cord-017772-zpf1xjqi 47 6 with with IN cord-017772-zpf1xjqi 47 7 an an DT cord-017772-zpf1xjqi 47 8 incidence incidence NN cord-017772-zpf1xjqi 47 9 of of IN cord-017772-zpf1xjqi 47 10 10 10 CD cord-017772-zpf1xjqi 47 11 cases case NNS cord-017772-zpf1xjqi 47 12 per per IN cord-017772-zpf1xjqi 47 13 million million CD cord-017772-zpf1xjqi 47 14 in in IN cord-017772-zpf1xjqi 47 15 the the DT cord-017772-zpf1xjqi 47 16 United United NNP cord-017772-zpf1xjqi 47 17 States States NNP cord-017772-zpf1xjqi 47 18 [ [ -LRB- cord-017772-zpf1xjqi 47 19 26 26 CD cord-017772-zpf1xjqi 47 20 ] ] -RRB- cord-017772-zpf1xjqi 47 21 . . . cord-017772-zpf1xjqi 48 1 Roughly roughly RB cord-017772-zpf1xjqi 48 2 75 75 CD cord-017772-zpf1xjqi 48 3 % % NN cord-017772-zpf1xjqi 48 4 of of IN cord-017772-zpf1xjqi 48 5 cases case NNS cord-017772-zpf1xjqi 48 6 of of IN cord-017772-zpf1xjqi 48 7 TTP TTP NNP cord-017772-zpf1xjqi 48 8 are be VBP cord-017772-zpf1xjqi 48 9 acquired acquire VBN cord-017772-zpf1xjqi 48 10 , , , cord-017772-zpf1xjqi 48 11 caused cause VBN cord-017772-zpf1xjqi 48 12 by by IN cord-017772-zpf1xjqi 48 13 the the DT cord-017772-zpf1xjqi 48 14 production production NN cord-017772-zpf1xjqi 48 15 of of IN cord-017772-zpf1xjqi 48 16 IgG IgG NNP cord-017772-zpf1xjqi 48 17 autoantibodies autoantibody NNS cord-017772-zpf1xjqi 48 18 against against IN cord-017772-zpf1xjqi 48 19 ADAMTS ADAMTS NNP cord-017772-zpf1xjqi 48 20 13 13 CD cord-017772-zpf1xjqi 48 21 [ [ -LRB- cord-017772-zpf1xjqi 48 22 25 25 CD cord-017772-zpf1xjqi 48 23 ] ] -RRB- cord-017772-zpf1xjqi 48 24 . . . cord-017772-zpf1xjqi 49 1 Antibody antibody NN cord-017772-zpf1xjqi 49 2 production production NN cord-017772-zpf1xjqi 49 3 can can MD cord-017772-zpf1xjqi 49 4 be be VB cord-017772-zpf1xjqi 49 5 idiopathic idiopathic JJ cord-017772-zpf1xjqi 49 6 ( ( -LRB- cord-017772-zpf1xjqi 49 7 ≅50 ≅50 CD cord-017772-zpf1xjqi 49 8 % % NN cord-017772-zpf1xjqi 49 9 of of IN cord-017772-zpf1xjqi 49 10 cases case NNS cord-017772-zpf1xjqi 49 11 ) ) -RRB- cord-017772-zpf1xjqi 49 12 or or CC cord-017772-zpf1xjqi 49 13 driven drive VBN cord-017772-zpf1xjqi 49 14 by by IN cord-017772-zpf1xjqi 49 15 a a DT cord-017772-zpf1xjqi 49 16 variety variety NN cord-017772-zpf1xjqi 49 17 of of IN cord-017772-zpf1xjqi 49 18 conditions condition NNS cord-017772-zpf1xjqi 49 19 including include VBG cord-017772-zpf1xjqi 49 20 malignancy malignancy NN cord-017772-zpf1xjqi 49 21 , , , cord-017772-zpf1xjqi 49 22 human human JJ cord-017772-zpf1xjqi 49 23 immunodeficiency immunodeficiency NN cord-017772-zpf1xjqi 49 24 virus virus NN cord-017772-zpf1xjqi 49 25 infection infection NN cord-017772-zpf1xjqi 49 26 , , , cord-017772-zpf1xjqi 49 27 pregnancy pregnancy NN cord-017772-zpf1xjqi 49 28 , , , cord-017772-zpf1xjqi 49 29 autoimmune autoimmune JJ cord-017772-zpf1xjqi 49 30 disease disease NN cord-017772-zpf1xjqi 49 31 , , , cord-017772-zpf1xjqi 49 32 medications medication NNS cord-017772-zpf1xjqi 49 33 , , , cord-017772-zpf1xjqi 49 34 and and CC cord-017772-zpf1xjqi 49 35 following follow VBG cord-017772-zpf1xjqi 49 36 organ organ NN cord-017772-zpf1xjqi 49 37 transplantation transplantation NN cord-017772-zpf1xjqi 49 38 [ [ -LRB- cord-017772-zpf1xjqi 49 39 27 27 CD cord-017772-zpf1xjqi 49 40 ] ] -RRB- cord-017772-zpf1xjqi 49 41 . . . cord-017772-zpf1xjqi 50 1 TTP TTP NNP cord-017772-zpf1xjqi 50 2 has have VBZ cord-017772-zpf1xjqi 50 3 historically historically RB cord-017772-zpf1xjqi 50 4 been be VBN cord-017772-zpf1xjqi 50 5 associated associate VBN cord-017772-zpf1xjqi 50 6 with with IN cord-017772-zpf1xjqi 50 7 a a DT cord-017772-zpf1xjqi 50 8 clinical clinical JJ cord-017772-zpf1xjqi 50 9 pentad pentad NN cord-017772-zpf1xjqi 50 10 of of IN cord-017772-zpf1xjqi 50 11 MAHA MAHA NNP cord-017772-zpf1xjqi 50 12 , , , cord-017772-zpf1xjqi 50 13 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 50 14 , , , cord-017772-zpf1xjqi 50 15 neurologic neurologic JJ cord-017772-zpf1xjqi 50 16 symptoms symptom NNS cord-017772-zpf1xjqi 50 17 , , , cord-017772-zpf1xjqi 50 18 renal renal JJ cord-017772-zpf1xjqi 50 19 impairment impairment NN cord-017772-zpf1xjqi 50 20 , , , cord-017772-zpf1xjqi 50 21 and and CC cord-017772-zpf1xjqi 50 22 fever fever NN cord-017772-zpf1xjqi 50 23 . . . cord-017772-zpf1xjqi 51 1 In in IN cord-017772-zpf1xjqi 51 2 the the DT cord-017772-zpf1xjqi 51 3 modern modern JJ cord-017772-zpf1xjqi 51 4 era era NN cord-017772-zpf1xjqi 51 5 , , , cord-017772-zpf1xjqi 51 6 this this DT cord-017772-zpf1xjqi 51 7 constellation constellation NN cord-017772-zpf1xjqi 51 8 of of IN cord-017772-zpf1xjqi 51 9 symptoms symptom NNS cord-017772-zpf1xjqi 51 10 is be VBZ cord-017772-zpf1xjqi 51 11 rarely rarely RB cord-017772-zpf1xjqi 51 12 seen see VBN cord-017772-zpf1xjqi 51 13 [ [ -LRB- cord-017772-zpf1xjqi 51 14 27 27 CD cord-017772-zpf1xjqi 51 15 ] ] -RRB- cord-017772-zpf1xjqi 51 16 . . . cord-017772-zpf1xjqi 52 1 While while IN cord-017772-zpf1xjqi 52 2 MAHA MAHA NNP cord-017772-zpf1xjqi 52 3 and and CC cord-017772-zpf1xjqi 52 4 thrombocytopenia thrombocytopenia NNS cord-017772-zpf1xjqi 52 5 are be VBP cord-017772-zpf1xjqi 52 6 universally universally RB cord-017772-zpf1xjqi 52 7 present present JJ cord-017772-zpf1xjqi 52 8 , , , cord-017772-zpf1xjqi 52 9 upwards upwards RB cord-017772-zpf1xjqi 52 10 of of IN cord-017772-zpf1xjqi 52 11 90 90 CD cord-017772-zpf1xjqi 52 12 % % NN cord-017772-zpf1xjqi 52 13 of of IN cord-017772-zpf1xjqi 52 14 patients patient NNS cord-017772-zpf1xjqi 52 15 will will MD cord-017772-zpf1xjqi 52 16 be be VB cord-017772-zpf1xjqi 52 17 afebrile afebrile JJ cord-017772-zpf1xjqi 52 18 and and CC cord-017772-zpf1xjqi 52 19 50 50 CD cord-017772-zpf1xjqi 52 20 % % NN cord-017772-zpf1xjqi 52 21 will will MD cord-017772-zpf1xjqi 52 22 have have VB cord-017772-zpf1xjqi 52 23 either either CC cord-017772-zpf1xjqi 52 24 normal normal JJ cord-017772-zpf1xjqi 52 25 mental mental JJ cord-017772-zpf1xjqi 52 26 status status NN cord-017772-zpf1xjqi 52 27 or or CC cord-017772-zpf1xjqi 52 28 renal renal JJ cord-017772-zpf1xjqi 52 29 function function NN cord-017772-zpf1xjqi 52 30 [ [ -LRB- cord-017772-zpf1xjqi 52 31 28 28 CD cord-017772-zpf1xjqi 52 32 ] ] -RRB- cord-017772-zpf1xjqi 52 33 . . . cord-017772-zpf1xjqi 53 1 Presenting present VBG cord-017772-zpf1xjqi 53 2 symptoms symptom NNS cord-017772-zpf1xjqi 53 3 are be VBP cord-017772-zpf1xjqi 53 4 often often RB cord-017772-zpf1xjqi 53 5 non non JJ cord-017772-zpf1xjqi 53 6 - - JJ cord-017772-zpf1xjqi 53 7 specific specific JJ cord-017772-zpf1xjqi 53 8 and and CC cord-017772-zpf1xjqi 53 9 include include VBP cord-017772-zpf1xjqi 53 10 nausea nausea NN cord-017772-zpf1xjqi 53 11 and and CC cord-017772-zpf1xjqi 53 12 abdominal abdominal JJ cord-017772-zpf1xjqi 53 13 pain pain NN cord-017772-zpf1xjqi 53 14 [ [ -LRB- cord-017772-zpf1xjqi 53 15 24 24 CD cord-017772-zpf1xjqi 53 16 ] ] -RRB- cord-017772-zpf1xjqi 53 17 . . . cord-017772-zpf1xjqi 54 1 Initial initial JJ cord-017772-zpf1xjqi 54 2 laboratory laboratory NN cord-017772-zpf1xjqi 54 3 testing testing NN cord-017772-zpf1xjqi 54 4 in in IN cord-017772-zpf1xjqi 54 5 patients patient NNS cord-017772-zpf1xjqi 54 6 with with IN cord-017772-zpf1xjqi 54 7 suspected suspect VBN cord-017772-zpf1xjqi 54 8 TTP TTP NNP cord-017772-zpf1xjqi 54 9 should should MD cord-017772-zpf1xjqi 54 10 confirm confirm VB cord-017772-zpf1xjqi 54 11 the the DT cord-017772-zpf1xjqi 54 12 presence presence NN cord-017772-zpf1xjqi 54 13 of of IN cord-017772-zpf1xjqi 54 14 hemolysis hemolysis NN cord-017772-zpf1xjqi 54 15 ( ( -LRB- cord-017772-zpf1xjqi 54 16 e.g. e.g. RB cord-017772-zpf1xjqi 54 17 , , , cord-017772-zpf1xjqi 54 18 an an DT cord-017772-zpf1xjqi 54 19 elevated elevated JJ cord-017772-zpf1xjqi 54 20 lactate lactate NN cord-017772-zpf1xjqi 54 21 dehydrogenase dehydrogenase NN cord-017772-zpf1xjqi 54 22 level level NN cord-017772-zpf1xjqi 54 23 , , , cord-017772-zpf1xjqi 54 24 low low JJ cord-017772-zpf1xjqi 54 25 haptoglobin haptoglobin NN cord-017772-zpf1xjqi 54 26 , , , cord-017772-zpf1xjqi 54 27 elevated elevated JJ cord-017772-zpf1xjqi 54 28 indirect indirect JJ cord-017772-zpf1xjqi 54 29 bilirubin bilirubin NN cord-017772-zpf1xjqi 54 30 , , , cord-017772-zpf1xjqi 54 31 and and CC cord-017772-zpf1xjqi 54 32 elevated elevated JJ cord-017772-zpf1xjqi 54 33 reticulocyte reticulocyte NN cord-017772-zpf1xjqi 54 34 index index NN cord-017772-zpf1xjqi 54 35 ) ) -RRB- cord-017772-zpf1xjqi 54 36 . . . cord-017772-zpf1xjqi 55 1 In in IN cord-017772-zpf1xjqi 55 2 contrast contrast NN cord-017772-zpf1xjqi 55 3 to to IN cord-017772-zpf1xjqi 55 4 DIC DIC NNP cord-017772-zpf1xjqi 55 5 , , , cord-017772-zpf1xjqi 55 6 coagulation coagulation NN cord-017772-zpf1xjqi 55 7 parameters parameter NNS cord-017772-zpf1xjqi 55 8 are be VBP cord-017772-zpf1xjqi 55 9 typically typically RB cord-017772-zpf1xjqi 55 10 normal normal JJ cord-017772-zpf1xjqi 55 11 . . . cord-017772-zpf1xjqi 56 1 A a DT cord-017772-zpf1xjqi 56 2 peripheral peripheral JJ cord-017772-zpf1xjqi 56 3 blood blood NN cord-017772-zpf1xjqi 56 4 smear smear NN cord-017772-zpf1xjqi 56 5 should should MD cord-017772-zpf1xjqi 56 6 be be VB cord-017772-zpf1xjqi 56 7 reviewed review VBN cord-017772-zpf1xjqi 56 8 to to TO cord-017772-zpf1xjqi 56 9 identify identify VB cord-017772-zpf1xjqi 56 10 fragmented fragmented JJ cord-017772-zpf1xjqi 56 11 red red JJ cord-017772-zpf1xjqi 56 12 blood blood NN cord-017772-zpf1xjqi 56 13 cells cell NNS cord-017772-zpf1xjqi 56 14 called call VBD cord-017772-zpf1xjqi 56 15 schistocytes schistocytes NNP cord-017772-zpf1xjqi 56 16 -one -one : cord-017772-zpf1xjqi 56 17 of of IN cord-017772-zpf1xjqi 56 18 the the DT cord-017772-zpf1xjqi 56 19 histologic histologic JJ cord-017772-zpf1xjqi 56 20 hallmarks hallmark NNS cord-017772-zpf1xjqi 56 21 of of IN cord-017772-zpf1xjqi 56 22 TMA TMA NNP cord-017772-zpf1xjqi 56 23 ( ( -LRB- cord-017772-zpf1xjqi 56 24 Fig Fig NNP cord-017772-zpf1xjqi 56 25 . . . cord-017772-zpf1xjqi 56 26 83.2 83.2 CD cord-017772-zpf1xjqi 56 27 ) ) -RRB- cord-017772-zpf1xjqi 56 28 . . . cord-017772-zpf1xjqi 57 1 Renal renal JJ cord-017772-zpf1xjqi 57 2 and and CC cord-017772-zpf1xjqi 57 3 cardiac cardiac JJ cord-017772-zpf1xjqi 57 4 biomarkers biomarker NNS cord-017772-zpf1xjqi 57 5 should should MD cord-017772-zpf1xjqi 57 6 be be VB cord-017772-zpf1xjqi 57 7 obtained obtain VBN cord-017772-zpf1xjqi 57 8 to to IN cord-017772-zpf1xjqi 57 9 screen screen NN cord-017772-zpf1xjqi 57 10 for for IN cord-017772-zpf1xjqi 57 11 organ organ NN cord-017772-zpf1xjqi 57 12 dysfunction dysfunction NN cord-017772-zpf1xjqi 57 13 . . . cord-017772-zpf1xjqi 58 1 The the DT cord-017772-zpf1xjqi 58 2 role role NN cord-017772-zpf1xjqi 58 3 of of IN cord-017772-zpf1xjqi 58 4 ADAMTS ADAMTS NNP cord-017772-zpf1xjqi 58 5 13 13 CD cord-017772-zpf1xjqi 58 6 assays assay NNS cord-017772-zpf1xjqi 58 7 is be VBZ cord-017772-zpf1xjqi 58 8 debated debate VBN cord-017772-zpf1xjqi 58 9 [ [ -LRB- cord-017772-zpf1xjqi 58 10 24 24 CD cord-017772-zpf1xjqi 58 11 , , , cord-017772-zpf1xjqi 58 12 25 25 CD cord-017772-zpf1xjqi 58 13 ] ] -RRB- cord-017772-zpf1xjqi 58 14 . . . cord-017772-zpf1xjqi 59 1 A a DT cord-017772-zpf1xjqi 59 2 severely severely RB cord-017772-zpf1xjqi 59 3 low low JJ cord-017772-zpf1xjqi 59 4 level level NN cord-017772-zpf1xjqi 59 5 ( ( -LRB- cord-017772-zpf1xjqi 59 6 < < NNP cord-017772-zpf1xjqi 59 7 5 5 CD cord-017772-zpf1xjqi 59 8 % % NN cord-017772-zpf1xjqi 59 9 ) ) -RRB- cord-017772-zpf1xjqi 59 10 confirms confirm VBZ cord-017772-zpf1xjqi 59 11 the the DT cord-017772-zpf1xjqi 59 12 diagnosis diagnosis NN cord-017772-zpf1xjqi 59 13 of of IN cord-017772-zpf1xjqi 59 14 TTP TTP NNP cord-017772-zpf1xjqi 59 15 . . . cord-017772-zpf1xjqi 60 1 However however RB cord-017772-zpf1xjqi 60 2 , , , cord-017772-zpf1xjqi 60 3 it -PRON- PRP cord-017772-zpf1xjqi 60 4 is be VBZ cord-017772-zpf1xjqi 60 5 imperative imperative JJ cord-017772-zpf1xjqi 60 6 that that IN cord-017772-zpf1xjqi 60 7 the the DT cord-017772-zpf1xjqi 60 8 decision decision NN cord-017772-zpf1xjqi 60 9 to to TO cord-017772-zpf1xjqi 60 10 initiate initiate VB cord-017772-zpf1xjqi 60 11 therapy therapy NN cord-017772-zpf1xjqi 60 12 is be VBZ cord-017772-zpf1xjqi 60 13 made make VBN cord-017772-zpf1xjqi 60 14 urgently urgently RB cord-017772-zpf1xjqi 60 15 on on IN cord-017772-zpf1xjqi 60 16 the the DT cord-017772-zpf1xjqi 60 17 basis basis NN cord-017772-zpf1xjqi 60 18 of of IN cord-017772-zpf1xjqi 60 19 an an DT cord-017772-zpf1xjqi 60 20 initial initial JJ cord-017772-zpf1xjqi 60 21 clinical clinical JJ cord-017772-zpf1xjqi 60 22 and and CC cord-017772-zpf1xjqi 60 23 laboratory laboratory NN cord-017772-zpf1xjqi 60 24 evaluation evaluation NN cord-017772-zpf1xjqi 60 25 without without IN cord-017772-zpf1xjqi 60 26 waiting wait VBG cord-017772-zpf1xjqi 60 27 for for IN cord-017772-zpf1xjqi 60 28 ADAMTS ADAMTS NNP cord-017772-zpf1xjqi 60 29 13 13 CD cord-017772-zpf1xjqi 60 30 activity activity NN cord-017772-zpf1xjqi 60 31 levels level NNS cord-017772-zpf1xjqi 60 32 to to TO cord-017772-zpf1xjqi 60 33 result result VB cord-017772-zpf1xjqi 60 34 [ [ -LRB- cord-017772-zpf1xjqi 60 35 29 29 CD cord-017772-zpf1xjqi 60 36 ] ] -RRB- cord-017772-zpf1xjqi 60 37 . . . cord-017772-zpf1xjqi 61 1 TTP TTP NNP cord-017772-zpf1xjqi 61 2 was be VBD cord-017772-zpf1xjqi 61 3 previously previously RB cord-017772-zpf1xjqi 61 4 viewed view VBN cord-017772-zpf1xjqi 61 5 as as IN cord-017772-zpf1xjqi 61 6 an an DT cord-017772-zpf1xjqi 61 7 almost almost RB cord-017772-zpf1xjqi 61 8 universally universally RB cord-017772-zpf1xjqi 61 9 fatal fatal JJ cord-017772-zpf1xjqi 61 10 diagnosis diagnosis NN cord-017772-zpf1xjqi 61 11 . . . cord-017772-zpf1xjqi 62 1 However however RB cord-017772-zpf1xjqi 62 2 , , , cord-017772-zpf1xjqi 62 3 with with IN cord-017772-zpf1xjqi 62 4 the the DT cord-017772-zpf1xjqi 62 5 rapid rapid JJ cord-017772-zpf1xjqi 62 6 initiation initiation NN cord-017772-zpf1xjqi 62 7 of of IN cord-017772-zpf1xjqi 62 8 plasma plasma NN cord-017772-zpf1xjqi 62 9 exchange exchange NN cord-017772-zpf1xjqi 62 10 , , , cord-017772-zpf1xjqi 62 11 survival survival NN cord-017772-zpf1xjqi 62 12 rates rate NNS cord-017772-zpf1xjqi 62 13 now now RB cord-017772-zpf1xjqi 62 14 approach approach VBP cord-017772-zpf1xjqi 62 15 90 90 CD cord-017772-zpf1xjqi 62 16 % % NN cord-017772-zpf1xjqi 62 17 [ [ -LRB- cord-017772-zpf1xjqi 62 18 24 24 CD cord-017772-zpf1xjqi 62 19 , , , cord-017772-zpf1xjqi 62 20 30 30 CD cord-017772-zpf1xjqi 62 21 ] ] -RRB- cord-017772-zpf1xjqi 62 22 . . . cord-017772-zpf1xjqi 63 1 Plasma plasma NN cord-017772-zpf1xjqi 63 2 exchange exchange NN cord-017772-zpf1xjqi 63 3 should should MD cord-017772-zpf1xjqi 63 4 be be VB cord-017772-zpf1xjqi 63 5 continued continue VBN cord-017772-zpf1xjqi 63 6 until until IN cord-017772-zpf1xjqi 63 7 platelet platelet NN cord-017772-zpf1xjqi 63 8 counts count NNS cord-017772-zpf1xjqi 63 9 are be VBP cord-017772-zpf1xjqi 63 10 > > NFP cord-017772-zpf1xjqi 63 11 150 150 CD cord-017772-zpf1xjqi 63 12 × × NN cord-017772-zpf1xjqi 63 13 10 10 CD cord-017772-zpf1xjqi 63 14 9 9 CD cord-017772-zpf1xjqi 63 15 cells cell NNS cord-017772-zpf1xjqi 63 16 / / SYM cord-017772-zpf1xjqi 63 17 L l NN cord-017772-zpf1xjqi 63 18 for for IN cord-017772-zpf1xjqi 63 19 2 2 CD cord-017772-zpf1xjqi 63 20 days day NNS cord-017772-zpf1xjqi 63 21 [ [ -LRB- cord-017772-zpf1xjqi 63 22 29 29 CD cord-017772-zpf1xjqi 63 23 ] ] -RRB- cord-017772-zpf1xjqi 63 24 . . . cord-017772-zpf1xjqi 64 1 Steroids steroid NNS cord-017772-zpf1xjqi 64 2 and and CC cord-017772-zpf1xjqi 64 3 rituximab rituximab NN cord-017772-zpf1xjqi 64 4 may may MD cord-017772-zpf1xjqi 64 5 have have VB cord-017772-zpf1xjqi 64 6 a a DT cord-017772-zpf1xjqi 64 7 role role NN cord-017772-zpf1xjqi 64 8 in in IN cord-017772-zpf1xjqi 64 9 the the DT cord-017772-zpf1xjqi 64 10 treatment treatment NN cord-017772-zpf1xjqi 64 11 of of IN cord-017772-zpf1xjqi 64 12 refractory refractory JJ cord-017772-zpf1xjqi 64 13 and and CC cord-017772-zpf1xjqi 64 14 recurrent recurrent JJ cord-017772-zpf1xjqi 64 15 disease disease NN cord-017772-zpf1xjqi 64 16 [ [ -LRB- cord-017772-zpf1xjqi 64 17 25 25 CD cord-017772-zpf1xjqi 64 18 ] ] -RRB- cord-017772-zpf1xjqi 64 19 . . . cord-017772-zpf1xjqi 65 1 DIC DIC NNP cord-017772-zpf1xjqi 65 2 is be VBZ cord-017772-zpf1xjqi 65 3 defined define VBN cord-017772-zpf1xjqi 65 4 by by IN cord-017772-zpf1xjqi 65 5 the the DT cord-017772-zpf1xjqi 65 6 International International NNP cord-017772-zpf1xjqi 65 7 Society Society NNP cord-017772-zpf1xjqi 65 8 on on IN cord-017772-zpf1xjqi 65 9 Thrombosis Thrombosis NNP cord-017772-zpf1xjqi 65 10 and and CC cord-017772-zpf1xjqi 65 11 Haemostasis Haemostasis NNP cord-017772-zpf1xjqi 65 12 ( ( -LRB- cord-017772-zpf1xjqi 65 13 ISTH ISTH NNP cord-017772-zpf1xjqi 65 14 ) ) -RRB- cord-017772-zpf1xjqi 65 15 as as IN cord-017772-zpf1xjqi 65 16 " " `` cord-017772-zpf1xjqi 65 17 an an DT cord-017772-zpf1xjqi 65 18 acquired acquire VBN cord-017772-zpf1xjqi 65 19 syndrome syndrome NN cord-017772-zpf1xjqi 65 20 characterized characterize VBN cord-017772-zpf1xjqi 65 21 by by IN cord-017772-zpf1xjqi 65 22 the the DT cord-017772-zpf1xjqi 65 23 intravascular intravascular JJ cord-017772-zpf1xjqi 65 24 activation activation NN cord-017772-zpf1xjqi 65 25 of of IN cord-017772-zpf1xjqi 65 26 coagulation coagulation NN cord-017772-zpf1xjqi 65 27 with with IN cord-017772-zpf1xjqi 65 28 a a DT cord-017772-zpf1xjqi 65 29 loss loss NN cord-017772-zpf1xjqi 65 30 of of IN cord-017772-zpf1xjqi 65 31 localization localization NN cord-017772-zpf1xjqi 65 32 arising arise VBG cord-017772-zpf1xjqi 65 33 from from IN cord-017772-zpf1xjqi 65 34 different different JJ cord-017772-zpf1xjqi 65 35 causes cause NNS cord-017772-zpf1xjqi 65 36 . . . cord-017772-zpf1xjqi 66 1 It -PRON- PRP cord-017772-zpf1xjqi 66 2 can can MD cord-017772-zpf1xjqi 66 3 originate originate VB cord-017772-zpf1xjqi 66 4 from from IN cord-017772-zpf1xjqi 66 5 and and CC cord-017772-zpf1xjqi 66 6 cause cause VB cord-017772-zpf1xjqi 66 7 damage damage NN cord-017772-zpf1xjqi 66 8 to to IN cord-017772-zpf1xjqi 66 9 the the DT cord-017772-zpf1xjqi 66 10 microvasculature microvasculature NN cord-017772-zpf1xjqi 66 11 , , , cord-017772-zpf1xjqi 66 12 which which WDT cord-017772-zpf1xjqi 66 13 if if IN cord-017772-zpf1xjqi 66 14 sufficiently sufficiently RB cord-017772-zpf1xjqi 66 15 severe severe JJ cord-017772-zpf1xjqi 66 16 , , , cord-017772-zpf1xjqi 66 17 can can MD cord-017772-zpf1xjqi 66 18 produce produce VB cord-017772-zpf1xjqi 66 19 organ organ NN cord-017772-zpf1xjqi 66 20 dysfunction dysfunction NN cord-017772-zpf1xjqi 66 21 . . . cord-017772-zpf1xjqi 66 22 " " '' cord-017772-zpf1xjqi 67 1 [ [ -LRB- cord-017772-zpf1xjqi 67 2 31 31 CD cord-017772-zpf1xjqi 67 3 ] ] -RRB- cord-017772-zpf1xjqi 68 1 The the DT cord-017772-zpf1xjqi 68 2 pathobiology pathobiology NN cord-017772-zpf1xjqi 68 3 of of IN cord-017772-zpf1xjqi 68 4 DIC DIC NNP cord-017772-zpf1xjqi 68 5 is be VBZ cord-017772-zpf1xjqi 68 6 complex complex JJ cord-017772-zpf1xjqi 68 7 and and CC cord-017772-zpf1xjqi 68 8 is be VBZ cord-017772-zpf1xjqi 68 9 driven drive VBN cord-017772-zpf1xjqi 68 10 by by IN cord-017772-zpf1xjqi 68 11 dysregulated dysregulated JJ cord-017772-zpf1xjqi 68 12 coagulation coagulation NN cord-017772-zpf1xjqi 68 13 and and CC cord-017772-zpf1xjqi 68 14 fibrinolysis fibrinolysis NN cord-017772-zpf1xjqi 68 15 pathways pathway NNS cord-017772-zpf1xjqi 68 16 . . . cord-017772-zpf1xjqi 69 1 A a DT cord-017772-zpf1xjqi 69 2 central central JJ cord-017772-zpf1xjqi 69 3 component component NN cord-017772-zpf1xjqi 69 4 of of IN cord-017772-zpf1xjqi 69 5 DIC DIC NNP cord-017772-zpf1xjqi 69 6 is be VBZ cord-017772-zpf1xjqi 69 7 excessive excessive JJ cord-017772-zpf1xjqi 69 8 tissue tissue NN cord-017772-zpf1xjqi 69 9 factor factor NN cord-017772-zpf1xjqi 69 10 ( ( -LRB- cord-017772-zpf1xjqi 69 11 TF TF NNP cord-017772-zpf1xjqi 69 12 ) ) -RRB- cord-017772-zpf1xjqi 69 13 expression expression NN cord-017772-zpf1xjqi 69 14 and and CC cord-017772-zpf1xjqi 69 15 thrombin thrombin JJ cord-017772-zpf1xjqi 69 16 generation generation NN cord-017772-zpf1xjqi 69 17 . . . cord-017772-zpf1xjqi 70 1 Depending depend VBG cord-017772-zpf1xjqi 70 2 on on IN cord-017772-zpf1xjqi 70 3 the the DT cord-017772-zpf1xjqi 70 4 clinical clinical JJ cord-017772-zpf1xjqi 70 5 scenario scenario NN cord-017772-zpf1xjqi 70 6 , , , cord-017772-zpf1xjqi 70 7 this this DT cord-017772-zpf1xjqi 70 8 can can MD cord-017772-zpf1xjqi 70 9 be be VB cord-017772-zpf1xjqi 70 10 caused cause VBN cord-017772-zpf1xjqi 70 11 by by IN cord-017772-zpf1xjqi 70 12 the the DT cord-017772-zpf1xjqi 70 13 release release NN cord-017772-zpf1xjqi 70 14 of of IN cord-017772-zpf1xjqi 70 15 inflammatory inflammatory JJ cord-017772-zpf1xjqi 70 16 cytokines cytokine NNS cord-017772-zpf1xjqi 70 17 including include VBG cord-017772-zpf1xjqi 70 18 IL-1 IL-1 NNP cord-017772-zpf1xjqi 70 19 and and CC cord-017772-zpf1xjqi 70 20 Il-6 Il-6 NNP cord-017772-zpf1xjqi 70 21 , , , cord-017772-zpf1xjqi 70 22 increased increase VBD cord-017772-zpf1xjqi 70 23 TF TF NNP cord-017772-zpf1xjqi 70 24 expression expression NN cord-017772-zpf1xjqi 70 25 on on IN cord-017772-zpf1xjqi 70 26 mononuclear mononuclear JJ cord-017772-zpf1xjqi 70 27 cells cell NNS cord-017772-zpf1xjqi 70 28 , , , cord-017772-zpf1xjqi 70 29 injury injury NN cord-017772-zpf1xjqi 70 30 to to IN cord-017772-zpf1xjqi 70 31 vascular vascular JJ cord-017772-zpf1xjqi 70 32 endothelial endothelial JJ cord-017772-zpf1xjqi 70 33 cells cell NNS cord-017772-zpf1xjqi 70 34 , , , cord-017772-zpf1xjqi 70 35 and and CC cord-017772-zpf1xjqi 70 36 exposure exposure NN cord-017772-zpf1xjqi 70 37 to to IN cord-017772-zpf1xjqi 70 38 pro pro JJ cord-017772-zpf1xjqi 70 39 - - JJ cord-017772-zpf1xjqi 70 40 coagulant coagulant JJ cord-017772-zpf1xjqi 70 41 molecules molecule NNS cord-017772-zpf1xjqi 70 42 ( ( -LRB- cord-017772-zpf1xjqi 70 43 e.g. e.g. DT cord-017772-zpf1xjqi 70 44 amniotic amniotic NN cord-017772-zpf1xjqi 70 45 fluid fluid NN cord-017772-zpf1xjqi 70 46 ) ) -RRB- cord-017772-zpf1xjqi 70 47 [ [ -LRB- cord-017772-zpf1xjqi 70 48 32 32 CD cord-017772-zpf1xjqi 70 49 ] ] -RRB- cord-017772-zpf1xjqi 70 50 . . . cord-017772-zpf1xjqi 71 1 Activated activate VBN cord-017772-zpf1xjqi 71 2 platelets platelet NNS cord-017772-zpf1xjqi 71 3 contribute contribute VBP cord-017772-zpf1xjqi 71 4 to to IN cord-017772-zpf1xjqi 71 5 excessive excessive JJ cord-017772-zpf1xjqi 71 6 thrombin thrombin JJ cord-017772-zpf1xjqi 71 7 generation generation NN cord-017772-zpf1xjqi 71 8 and and CC cord-017772-zpf1xjqi 71 9 the the DT cord-017772-zpf1xjqi 71 10 formation formation NN cord-017772-zpf1xjqi 71 11 of of IN cord-017772-zpf1xjqi 71 12 microvascular microvascular JJ cord-017772-zpf1xjqi 71 13 clots clot NNS cord-017772-zpf1xjqi 71 14 . . . cord-017772-zpf1xjqi 72 1 Concurrently concurrently RB cord-017772-zpf1xjqi 72 2 , , , cord-017772-zpf1xjqi 72 3 Fragmented fragmented JJ cord-017772-zpf1xjqi 72 4 red red JJ cord-017772-zpf1xjqi 72 5 blood blood NN cord-017772-zpf1xjqi 72 6 cells cell NNS cord-017772-zpf1xjqi 72 7 ( ( -LRB- cord-017772-zpf1xjqi 72 8 schistocytes schistocytes NNP cord-017772-zpf1xjqi 72 9 ) ) -RRB- cord-017772-zpf1xjqi 72 10 are be VBP cord-017772-zpf1xjqi 72 11 identified identify VBN cord-017772-zpf1xjqi 72 12 by by IN cord-017772-zpf1xjqi 72 13 * * NFP cord-017772-zpf1xjqi 72 14 the the DT cord-017772-zpf1xjqi 72 15 3 3 CD cord-017772-zpf1xjqi 72 16 major major JJ cord-017772-zpf1xjqi 72 17 anticoagulant anticoagulant JJ cord-017772-zpf1xjqi 72 18 systems system NNS cord-017772-zpf1xjqi 72 19 ( ( -LRB- cord-017772-zpf1xjqi 72 20 antithrombin antithrombin NN cord-017772-zpf1xjqi 72 21 , , , cord-017772-zpf1xjqi 72 22 the the DT cord-017772-zpf1xjqi 72 23 protein protein NN cord-017772-zpf1xjqi 72 24 C c NN cord-017772-zpf1xjqi 72 25 system system NN cord-017772-zpf1xjqi 72 26 , , , cord-017772-zpf1xjqi 72 27 and and CC cord-017772-zpf1xjqi 72 28 TF TF NNP cord-017772-zpf1xjqi 72 29 pathway pathway NN cord-017772-zpf1xjqi 72 30 inhibitor inhibitor NN cord-017772-zpf1xjqi 72 31 ) ) -RRB- cord-017772-zpf1xjqi 72 32 are be VBP cord-017772-zpf1xjqi 72 33 dampened dampen VBN cord-017772-zpf1xjqi 72 34 due due IN cord-017772-zpf1xjqi 72 35 to to IN cord-017772-zpf1xjqi 72 36 impaired impaired JJ cord-017772-zpf1xjqi 72 37 synthesis synthesis NN cord-017772-zpf1xjqi 72 38 and and CC cord-017772-zpf1xjqi 72 39 increased increase VBN cord-017772-zpf1xjqi 72 40 degradation degradation NN cord-017772-zpf1xjqi 72 41 of of IN cord-017772-zpf1xjqi 72 42 the the DT cord-017772-zpf1xjqi 72 43 relevant relevant JJ cord-017772-zpf1xjqi 72 44 factors factor NNS cord-017772-zpf1xjqi 72 45 [ [ -LRB- cord-017772-zpf1xjqi 72 46 32 32 CD cord-017772-zpf1xjqi 72 47 ] ] -RRB- cord-017772-zpf1xjqi 72 48 . . . cord-017772-zpf1xjqi 73 1 Finally finally RB cord-017772-zpf1xjqi 73 2 , , , cord-017772-zpf1xjqi 73 3 intrinsic intrinsic JJ cord-017772-zpf1xjqi 73 4 fibrinolysis fibrinolysis NN cord-017772-zpf1xjqi 73 5 is be VBZ cord-017772-zpf1xjqi 73 6 impaired impair VBN cord-017772-zpf1xjqi 73 7 in in IN cord-017772-zpf1xjqi 73 8 part part NN cord-017772-zpf1xjqi 73 9 due due IN cord-017772-zpf1xjqi 73 10 to to IN cord-017772-zpf1xjqi 73 11 elevated elevated JJ cord-017772-zpf1xjqi 73 12 levels level NNS cord-017772-zpf1xjqi 73 13 of of IN cord-017772-zpf1xjqi 73 14 plasminogen plasminogen NN cord-017772-zpf1xjqi 73 15 activator activator NN cord-017772-zpf1xjqi 73 16 inhibitor inhibitor NN cord-017772-zpf1xjqi 73 17 1 1 CD cord-017772-zpf1xjqi 73 18 . . . cord-017772-zpf1xjqi 74 1 The the DT cord-017772-zpf1xjqi 74 2 propagation propagation NN cord-017772-zpf1xjqi 74 3 of of IN cord-017772-zpf1xjqi 74 4 microvascular microvascular JJ cord-017772-zpf1xjqi 74 5 thrombi thrombi NNP cord-017772-zpf1xjqi 74 6 leads lead VBZ cord-017772-zpf1xjqi 74 7 to to IN cord-017772-zpf1xjqi 74 8 organ organ NN cord-017772-zpf1xjqi 74 9 ischemia ischemia NN cord-017772-zpf1xjqi 74 10 and and CC cord-017772-zpf1xjqi 74 11 dysfunction dysfunction NN cord-017772-zpf1xjqi 74 12 - - HYPH cord-017772-zpf1xjqi 74 13 one one CD cord-017772-zpf1xjqi 74 14 of of IN cord-017772-zpf1xjqi 74 15 the the DT cord-017772-zpf1xjqi 74 16 clinical clinical JJ cord-017772-zpf1xjqi 74 17 hallmarks hallmark NNS cord-017772-zpf1xjqi 74 18 of of IN cord-017772-zpf1xjqi 74 19 DIC DIC NNP cord-017772-zpf1xjqi 74 20 . . . cord-017772-zpf1xjqi 75 1 [ [ -LRB- cord-017772-zpf1xjqi 75 2 33 33 CD cord-017772-zpf1xjqi 75 3 ] ] -RRB- cord-017772-zpf1xjqi 76 1 By by IN cord-017772-zpf1xjqi 76 2 far far RB cord-017772-zpf1xjqi 76 3 , , , cord-017772-zpf1xjqi 76 4 the the DT cord-017772-zpf1xjqi 76 5 most most RBS cord-017772-zpf1xjqi 76 6 common common JJ cord-017772-zpf1xjqi 76 7 underlying underlying JJ cord-017772-zpf1xjqi 76 8 cause cause NN cord-017772-zpf1xjqi 76 9 of of IN cord-017772-zpf1xjqi 76 10 DIC DIC NNP cord-017772-zpf1xjqi 76 11 is be VBZ cord-017772-zpf1xjqi 76 12 sepsis sepsis NN cord-017772-zpf1xjqi 76 13 . . . cord-017772-zpf1xjqi 77 1 Depending depend VBG cord-017772-zpf1xjqi 77 2 on on IN cord-017772-zpf1xjqi 77 3 the the DT cord-017772-zpf1xjqi 77 4 patient patient JJ cord-017772-zpf1xjqi 77 5 population population NN cord-017772-zpf1xjqi 77 6 and and CC cord-017772-zpf1xjqi 77 7 definition definition NN cord-017772-zpf1xjqi 77 8 used use VBN cord-017772-zpf1xjqi 77 9 , , , cord-017772-zpf1xjqi 77 10 25 25 CD cord-017772-zpf1xjqi 77 11 - - SYM cord-017772-zpf1xjqi 77 12 60 60 CD cord-017772-zpf1xjqi 77 13 % % NN cord-017772-zpf1xjqi 77 14 of of IN cord-017772-zpf1xjqi 77 15 patients patient NNS cord-017772-zpf1xjqi 77 16 with with IN cord-017772-zpf1xjqi 77 17 sepsis sepsis NN cord-017772-zpf1xjqi 77 18 develop develop VB cord-017772-zpf1xjqi 77 19 DIC DIC NNP cord-017772-zpf1xjqi 77 20 [ [ -LRB- cord-017772-zpf1xjqi 77 21 32 32 CD cord-017772-zpf1xjqi 77 22 , , , cord-017772-zpf1xjqi 77 23 34 34 CD cord-017772-zpf1xjqi 77 24 , , , cord-017772-zpf1xjqi 77 25 35 35 CD cord-017772-zpf1xjqi 77 26 ] ] -RRB- cord-017772-zpf1xjqi 77 27 . . . cord-017772-zpf1xjqi 78 1 In in IN cord-017772-zpf1xjqi 78 2 cases case NNS cord-017772-zpf1xjqi 78 3 series series NN cord-017772-zpf1xjqi 78 4 , , , cord-017772-zpf1xjqi 78 5 sepsis sepsis NN cord-017772-zpf1xjqi 78 6 is be VBZ cord-017772-zpf1xjqi 78 7 identified identify VBN cord-017772-zpf1xjqi 78 8 as as IN cord-017772-zpf1xjqi 78 9 a a DT cord-017772-zpf1xjqi 78 10 risk risk NN cord-017772-zpf1xjqi 78 11 factor factor NN cord-017772-zpf1xjqi 78 12 for for IN cord-017772-zpf1xjqi 78 13 DIC DIC NNP cord-017772-zpf1xjqi 78 14 in in RB cord-017772-zpf1xjqi 78 15 over over IN cord-017772-zpf1xjqi 78 16 50 50 CD cord-017772-zpf1xjqi 78 17 % % NN cord-017772-zpf1xjqi 78 18 of of IN cord-017772-zpf1xjqi 78 19 patients patient NNS cord-017772-zpf1xjqi 78 20 [ [ -LRB- cord-017772-zpf1xjqi 78 21 36 36 CD cord-017772-zpf1xjqi 78 22 ] ] -RRB- cord-017772-zpf1xjqi 78 23 . . . cord-017772-zpf1xjqi 79 1 Other other JJ cord-017772-zpf1xjqi 79 2 important important JJ cord-017772-zpf1xjqi 79 3 causes cause NNS cord-017772-zpf1xjqi 79 4 of of IN cord-017772-zpf1xjqi 79 5 DIC DIC NNP cord-017772-zpf1xjqi 79 6 include include VBP cord-017772-zpf1xjqi 79 7 trauma trauma NN cord-017772-zpf1xjqi 79 8 , , , cord-017772-zpf1xjqi 79 9 obstetric obstetric JJ cord-017772-zpf1xjqi 79 10 emergencies emergency NNS cord-017772-zpf1xjqi 79 11 , , , cord-017772-zpf1xjqi 79 12 malignancies malignancy NNS cord-017772-zpf1xjqi 79 13 , , , cord-017772-zpf1xjqi 79 14 and and CC cord-017772-zpf1xjqi 79 15 liver liver NN cord-017772-zpf1xjqi 79 16 failure failure NN cord-017772-zpf1xjqi 79 17 among among IN cord-017772-zpf1xjqi 79 18 many many JJ cord-017772-zpf1xjqi 79 19 others other NNS cord-017772-zpf1xjqi 79 20 [ [ -LRB- cord-017772-zpf1xjqi 79 21 32 32 CD cord-017772-zpf1xjqi 79 22 ] ] -RRB- cord-017772-zpf1xjqi 79 23 . . . cord-017772-zpf1xjqi 80 1 DIC DIC NNP cord-017772-zpf1xjqi 80 2 is be VBZ cord-017772-zpf1xjqi 80 3 consistently consistently RB cord-017772-zpf1xjqi 80 4 identified identify VBN cord-017772-zpf1xjqi 80 5 as as IN cord-017772-zpf1xjqi 80 6 a a DT cord-017772-zpf1xjqi 80 7 risk risk NN cord-017772-zpf1xjqi 80 8 factor factor NN cord-017772-zpf1xjqi 80 9 for for IN cord-017772-zpf1xjqi 80 10 increased increase VBN cord-017772-zpf1xjqi 80 11 mortality mortality NN cord-017772-zpf1xjqi 80 12 both both CC cord-017772-zpf1xjqi 80 13 in in IN cord-017772-zpf1xjqi 80 14 patients patient NNS cord-017772-zpf1xjqi 80 15 with with IN cord-017772-zpf1xjqi 80 16 sepsis sepsis NN cord-017772-zpf1xjqi 80 17 and and CC cord-017772-zpf1xjqi 80 18 in in IN cord-017772-zpf1xjqi 80 19 critically critically RB cord-017772-zpf1xjqi 80 20 ill ill JJ cord-017772-zpf1xjqi 80 21 patients patient NNS cord-017772-zpf1xjqi 80 22 more more RBR cord-017772-zpf1xjqi 80 23 broadly broadly RB cord-017772-zpf1xjqi 80 24 [ [ -LRB- cord-017772-zpf1xjqi 80 25 34 34 CD cord-017772-zpf1xjqi 80 26 , , , cord-017772-zpf1xjqi 80 27 36 36 CD cord-017772-zpf1xjqi 80 28 , , , cord-017772-zpf1xjqi 80 29 37 37 CD cord-017772-zpf1xjqi 80 30 ] ] -RRB- cord-017772-zpf1xjqi 80 31 . . . cord-017772-zpf1xjqi 81 1 The the DT cord-017772-zpf1xjqi 81 2 diagnosis diagnosis NN cord-017772-zpf1xjqi 81 3 of of IN cord-017772-zpf1xjqi 81 4 DIC DIC NNP cord-017772-zpf1xjqi 81 5 should should MD cord-017772-zpf1xjqi 81 6 be be VB cord-017772-zpf1xjqi 81 7 suspected suspect VBN cord-017772-zpf1xjqi 81 8 in in IN cord-017772-zpf1xjqi 81 9 any any DT cord-017772-zpf1xjqi 81 10 critically critically RB cord-017772-zpf1xjqi 81 11 ill ill JJ cord-017772-zpf1xjqi 81 12 patient patient NN cord-017772-zpf1xjqi 81 13 with with IN cord-017772-zpf1xjqi 81 14 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 81 15 , , , cord-017772-zpf1xjqi 81 16 abnormal abnormal JJ cord-017772-zpf1xjqi 81 17 coagulation coagulation NN cord-017772-zpf1xjqi 81 18 parameters parameter NNS cord-017772-zpf1xjqi 81 19 ( ( -LRB- cord-017772-zpf1xjqi 81 20 e.g. e.g. RB cord-017772-zpf1xjqi 81 21 , , , cord-017772-zpf1xjqi 81 22 a a DT cord-017772-zpf1xjqi 81 23 prolonged prolonged JJ cord-017772-zpf1xjqi 81 24 prothrombin prothrombin NN cord-017772-zpf1xjqi 81 25 and and CC cord-017772-zpf1xjqi 81 26 partial partial JJ cord-017772-zpf1xjqi 81 27 thromboplastin thromboplastin NNP cord-017772-zpf1xjqi 81 28 times time NNS cord-017772-zpf1xjqi 81 29 ) ) -RRB- cord-017772-zpf1xjqi 81 30 , , , cord-017772-zpf1xjqi 81 31 MAHA MAHA NNP cord-017772-zpf1xjqi 81 32 , , , cord-017772-zpf1xjqi 81 33 and and CC cord-017772-zpf1xjqi 81 34 laboratory laboratory NN cord-017772-zpf1xjqi 81 35 evidence evidence NN cord-017772-zpf1xjqi 81 36 of of IN cord-017772-zpf1xjqi 81 37 fibrinolysis fibrinolysis NN cord-017772-zpf1xjqi 81 38 ( ( -LRB- cord-017772-zpf1xjqi 81 39 e.g. e.g. RB cord-017772-zpf1xjqi 81 40 , , , cord-017772-zpf1xjqi 81 41 an an DT cord-017772-zpf1xjqi 81 42 elevated elevated JJ cord-017772-zpf1xjqi 81 43 d d NN cord-017772-zpf1xjqi 81 44 - - HYPH cord-017772-zpf1xjqi 81 45 dimer dimer JJ cord-017772-zpf1xjqi 81 46 and and CC cord-017772-zpf1xjqi 81 47 reduced reduced JJ cord-017772-zpf1xjqi 81 48 fibrinogen fibrinogen NN cord-017772-zpf1xjqi 81 49 ) ) -RRB- cord-017772-zpf1xjqi 81 50 [ [ -LRB- cord-017772-zpf1xjqi 81 51 38 38 CD cord-017772-zpf1xjqi 81 52 ] ] -RRB- cord-017772-zpf1xjqi 81 53 . . . cord-017772-zpf1xjqi 82 1 While while IN cord-017772-zpf1xjqi 82 2 catastrophic catastrophic JJ cord-017772-zpf1xjqi 82 3 hemorrhage hemorrhage NN cord-017772-zpf1xjqi 82 4 is be VBZ cord-017772-zpf1xjqi 82 5 uncommon uncommon JJ cord-017772-zpf1xjqi 82 6 , , , cord-017772-zpf1xjqi 82 7 most most JJS cord-017772-zpf1xjqi 82 8 patients patient NNS cord-017772-zpf1xjqi 82 9 have have VBP cord-017772-zpf1xjqi 82 10 evidence evidence NN cord-017772-zpf1xjqi 82 11 of of IN cord-017772-zpf1xjqi 82 12 bleeding bleed VBG cord-017772-zpf1xjqi 82 13 , , , cord-017772-zpf1xjqi 82 14 often often RB cord-017772-zpf1xjqi 82 15 at at IN cord-017772-zpf1xjqi 82 16 sites site NNS cord-017772-zpf1xjqi 82 17 of of IN cord-017772-zpf1xjqi 82 18 intravenous intravenous JJ cord-017772-zpf1xjqi 82 19 access access NN cord-017772-zpf1xjqi 82 20 [ [ -LRB- cord-017772-zpf1xjqi 82 21 33 33 CD cord-017772-zpf1xjqi 82 22 ] ] -RRB- cord-017772-zpf1xjqi 82 23 . . . cord-017772-zpf1xjqi 83 1 Diagnostic diagnostic JJ cord-017772-zpf1xjqi 83 2 criteria criterion NNS cord-017772-zpf1xjqi 83 3 developed develop VBN cord-017772-zpf1xjqi 83 4 by by IN cord-017772-zpf1xjqi 83 5 the the DT cord-017772-zpf1xjqi 83 6 ISTH ISTH NNP cord-017772-zpf1xjqi 83 7 are be VBP cord-017772-zpf1xjqi 83 8 available available JJ cord-017772-zpf1xjqi 83 9 to to TO cord-017772-zpf1xjqi 83 10 aid aid VB cord-017772-zpf1xjqi 83 11 diagnosis diagnosis NN cord-017772-zpf1xjqi 83 12 ( ( -LRB- cord-017772-zpf1xjqi 83 13 Table table NN cord-017772-zpf1xjqi 83 14 83 83 CD cord-017772-zpf1xjqi 83 15 .1 .1 CD cord-017772-zpf1xjqi 83 16 ) ) -RRB- cord-017772-zpf1xjqi 84 1 [ [ -LRB- cord-017772-zpf1xjqi 84 2 37 37 CD cord-017772-zpf1xjqi 84 3 ] ] -RRB- cord-017772-zpf1xjqi 84 4 . . . cord-017772-zpf1xjqi 85 1 In in IN cord-017772-zpf1xjqi 85 2 a a DT cord-017772-zpf1xjqi 85 3 prospective prospective JJ cord-017772-zpf1xjqi 85 4 validation validation NN cord-017772-zpf1xjqi 85 5 study study NN cord-017772-zpf1xjqi 85 6 , , , cord-017772-zpf1xjqi 85 7 a a DT cord-017772-zpf1xjqi 85 8 score score NN cord-017772-zpf1xjqi 85 9 > > XX cord-017772-zpf1xjqi 86 1 5 5 CD cord-017772-zpf1xjqi 86 2 had have VBD cord-017772-zpf1xjqi 86 3 a a DT cord-017772-zpf1xjqi 86 4 sensitivity sensitivity NN cord-017772-zpf1xjqi 86 5 of of IN cord-017772-zpf1xjqi 86 6 91 91 CD cord-017772-zpf1xjqi 86 7 % % NN cord-017772-zpf1xjqi 86 8 and and CC cord-017772-zpf1xjqi 86 9 specificity specificity NN cord-017772-zpf1xjqi 86 10 of of IN cord-017772-zpf1xjqi 86 11 97 97 CD cord-017772-zpf1xjqi 86 12 % % NN cord-017772-zpf1xjqi 86 13 for for IN cord-017772-zpf1xjqi 86 14 the the DT cord-017772-zpf1xjqi 86 15 diagnosis diagnosis NN cord-017772-zpf1xjqi 86 16 of of IN cord-017772-zpf1xjqi 86 17 DIC DIC NNP cord-017772-zpf1xjqi 86 18 [ [ -LRB- cord-017772-zpf1xjqi 86 19 39 39 CD cord-017772-zpf1xjqi 86 20 ] ] -RRB- cord-017772-zpf1xjqi 86 21 . . . cord-017772-zpf1xjqi 87 1 A a DT cord-017772-zpf1xjqi 87 2 score score NN cord-017772-zpf1xjqi 87 3 should should MD cord-017772-zpf1xjqi 87 4 be be VB cord-017772-zpf1xjqi 87 5 calculated calculate VBN cord-017772-zpf1xjqi 87 6 daily daily RB cord-017772-zpf1xjqi 87 7 both both DT cord-017772-zpf1xjqi 87 8 to to TO cord-017772-zpf1xjqi 87 9 accurately accurately RB cord-017772-zpf1xjqi 87 10 confirm confirm VB cord-017772-zpf1xjqi 87 11 the the DT cord-017772-zpf1xjqi 87 12 diagnosis diagnosis NN cord-017772-zpf1xjqi 87 13 and and CC cord-017772-zpf1xjqi 87 14 to to TO cord-017772-zpf1xjqi 87 15 aid aid VB cord-017772-zpf1xjqi 87 16 prognostication prognostication NN cord-017772-zpf1xjqi 87 17 [ [ -LRB- cord-017772-zpf1xjqi 87 18 40 40 CD cord-017772-zpf1xjqi 87 19 ] ] -RRB- cord-017772-zpf1xjqi 87 20 . . . cord-017772-zpf1xjqi 88 1 The the DT cord-017772-zpf1xjqi 88 2 foundation foundation NN cord-017772-zpf1xjqi 88 3 of of IN cord-017772-zpf1xjqi 88 4 DIC DIC NNP cord-017772-zpf1xjqi 88 5 management management NN cord-017772-zpf1xjqi 88 6 is be VBZ cord-017772-zpf1xjqi 88 7 treatment treatment NN cord-017772-zpf1xjqi 88 8 of of IN cord-017772-zpf1xjqi 88 9 the the DT cord-017772-zpf1xjqi 88 10 underlying underlying JJ cord-017772-zpf1xjqi 88 11 disorder disorder NN cord-017772-zpf1xjqi 88 12 . . . cord-017772-zpf1xjqi 89 1 There there EX cord-017772-zpf1xjqi 89 2 is be VBZ cord-017772-zpf1xjqi 89 3 limited limited JJ cord-017772-zpf1xjqi 89 4 data datum NNS cord-017772-zpf1xjqi 89 5 to to TO cord-017772-zpf1xjqi 89 6 guide guide VB cord-017772-zpf1xjqi 89 7 the the DT cord-017772-zpf1xjqi 89 8 administration administration NN cord-017772-zpf1xjqi 89 9 of of IN cord-017772-zpf1xjqi 89 10 blood blood NN cord-017772-zpf1xjqi 89 11 products product NNS cord-017772-zpf1xjqi 89 12 in in IN cord-017772-zpf1xjqi 89 13 DIC DIC NNP cord-017772-zpf1xjqi 89 14 . . . cord-017772-zpf1xjqi 90 1 In in IN cord-017772-zpf1xjqi 90 2 general general JJ cord-017772-zpf1xjqi 90 3 , , , cord-017772-zpf1xjqi 90 4 guidelines guideline NNS cord-017772-zpf1xjqi 90 5 agree agree VBP cord-017772-zpf1xjqi 90 6 that that IN cord-017772-zpf1xjqi 90 7 platelets platelet NNS cord-017772-zpf1xjqi 90 8 , , , cord-017772-zpf1xjqi 90 9 fresh fresh RB cord-017772-zpf1xjqi 90 10 - - HYPH cord-017772-zpf1xjqi 90 11 frozen frozen JJ cord-017772-zpf1xjqi 90 12 plasma plasma NN cord-017772-zpf1xjqi 90 13 , , , cord-017772-zpf1xjqi 90 14 and and CC cord-017772-zpf1xjqi 90 15 a a DT cord-017772-zpf1xjqi 90 16 source source NN cord-017772-zpf1xjqi 90 17 of of IN cord-017772-zpf1xjqi 90 18 fibrinogen fibrinogen NN cord-017772-zpf1xjqi 90 19 should should MD cord-017772-zpf1xjqi 90 20 be be VB cord-017772-zpf1xjqi 90 21 given give VBN cord-017772-zpf1xjqi 90 22 to to IN cord-017772-zpf1xjqi 90 23 patients patient NNS cord-017772-zpf1xjqi 90 24 who who WP cord-017772-zpf1xjqi 90 25 are be VBP cord-017772-zpf1xjqi 90 26 actively actively RB cord-017772-zpf1xjqi 90 27 bleeding bleed VBG cord-017772-zpf1xjqi 90 28 or or CC cord-017772-zpf1xjqi 90 29 those those DT cord-017772-zpf1xjqi 90 30 undergoing undergo VBG cord-017772-zpf1xjqi 90 31 invasive invasive JJ cord-017772-zpf1xjqi 90 32 procedures procedure NNS cord-017772-zpf1xjqi 90 33 [ [ -LRB- cord-017772-zpf1xjqi 90 34 41 41 CD cord-017772-zpf1xjqi 90 35 ] ] -RRB- cord-017772-zpf1xjqi 90 36 . . . cord-017772-zpf1xjqi 91 1 A a DT cord-017772-zpf1xjqi 91 2 platelet platelet NN cord-017772-zpf1xjqi 91 3 count count NN cord-017772-zpf1xjqi 91 4 > > XX cord-017772-zpf1xjqi 91 5 50 50 CD cord-017772-zpf1xjqi 91 6 × × NN cord-017772-zpf1xjqi 91 7 10 10 CD cord-017772-zpf1xjqi 91 8 9 9 CD cord-017772-zpf1xjqi 91 9 cells cell NNS cord-017772-zpf1xjqi 91 10 / / SYM cord-017772-zpf1xjqi 91 11 L l NN cord-017772-zpf1xjqi 91 12 , , , cord-017772-zpf1xjqi 91 13 prothrombin prothrombin NN cord-017772-zpf1xjqi 91 14 ( ( -LRB- cord-017772-zpf1xjqi 91 15 PT pt NN cord-017772-zpf1xjqi 91 16 ) ) -RRB- cord-017772-zpf1xjqi 92 1 and and CC cord-017772-zpf1xjqi 92 2 partial partial JJ cord-017772-zpf1xjqi 92 3 thromboplastin thromboplastin NNP cord-017772-zpf1xjqi 92 4 time time NN cord-017772-zpf1xjqi 92 5 ( ( -LRB- cord-017772-zpf1xjqi 92 6 aPTT aptt NN cord-017772-zpf1xjqi 92 7 ) ) -RRB- cord-017772-zpf1xjqi 92 8 < < XX cord-017772-zpf1xjqi 92 9 1.5 1.5 CD cord-017772-zpf1xjqi 92 10 times time NNS cord-017772-zpf1xjqi 92 11 normal normal JJ cord-017772-zpf1xjqi 92 12 , , , cord-017772-zpf1xjqi 92 13 and and CC cord-017772-zpf1xjqi 92 14 a a DT cord-017772-zpf1xjqi 92 15 fibrinogen fibrinogen NN cord-017772-zpf1xjqi 92 16 level level NN cord-017772-zpf1xjqi 92 17 > > XX cord-017772-zpf1xjqi 93 1 1.5 1.5 CD cord-017772-zpf1xjqi 93 2 g g NN cord-017772-zpf1xjqi 93 3 / / SYM cord-017772-zpf1xjqi 93 4 L L NNP cord-017772-zpf1xjqi 93 5 are be VBP cord-017772-zpf1xjqi 93 6 typical typical JJ cord-017772-zpf1xjqi 93 7 targets target NNS cord-017772-zpf1xjqi 93 8 [ [ -LRB- cord-017772-zpf1xjqi 93 9 19 19 CD cord-017772-zpf1xjqi 93 10 ] ] -RRB- cord-017772-zpf1xjqi 93 11 . . . cord-017772-zpf1xjqi 94 1 Recommendations recommendation NNS cord-017772-zpf1xjqi 94 2 for for IN cord-017772-zpf1xjqi 94 3 the the DT cord-017772-zpf1xjqi 94 4 use use NN cord-017772-zpf1xjqi 94 5 of of IN cord-017772-zpf1xjqi 94 6 heparin heparin NN cord-017772-zpf1xjqi 94 7 vary vary VBP cord-017772-zpf1xjqi 94 8 across across IN cord-017772-zpf1xjqi 94 9 guidelines guideline NNS cord-017772-zpf1xjqi 94 10 [ [ -LRB- cord-017772-zpf1xjqi 94 11 41 41 CD cord-017772-zpf1xjqi 94 12 ] ] -RRB- cord-017772-zpf1xjqi 94 13 . . . cord-017772-zpf1xjqi 95 1 In in IN cord-017772-zpf1xjqi 95 2 general general JJ cord-017772-zpf1xjqi 95 3 , , , cord-017772-zpf1xjqi 95 4 heparin heparin NNP cord-017772-zpf1xjqi 95 5 is be VBZ cord-017772-zpf1xjqi 95 6 reserved reserve VBN cord-017772-zpf1xjqi 95 7 for for IN cord-017772-zpf1xjqi 95 8 patients patient NNS cord-017772-zpf1xjqi 95 9 with with IN cord-017772-zpf1xjqi 95 10 clinical clinical JJ cord-017772-zpf1xjqi 95 11 evidence evidence NN cord-017772-zpf1xjqi 95 12 of of IN cord-017772-zpf1xjqi 95 13 thrombosis thrombosis NN cord-017772-zpf1xjqi 95 14 . . . cord-017772-zpf1xjqi 96 1 A a DT cord-017772-zpf1xjqi 96 2 host host NN cord-017772-zpf1xjqi 96 3 of of IN cord-017772-zpf1xjqi 96 4 targeted target VBN cord-017772-zpf1xjqi 96 5 interventions intervention NNS cord-017772-zpf1xjqi 96 6 aimed aim VBN cord-017772-zpf1xjqi 96 7 at at IN cord-017772-zpf1xjqi 96 8 augmenting augment VBG cord-017772-zpf1xjqi 96 9 the the DT cord-017772-zpf1xjqi 96 10 major major JJ cord-017772-zpf1xjqi 96 11 anticoagulant anticoagulant JJ cord-017772-zpf1xjqi 96 12 pathways pathway NNS cord-017772-zpf1xjqi 96 13 have have VBP cord-017772-zpf1xjqi 96 14 failed fail VBN cord-017772-zpf1xjqi 96 15 to to TO cord-017772-zpf1xjqi 96 16 show show VB cord-017772-zpf1xjqi 96 17 benefit benefit NN cord-017772-zpf1xjqi 96 18 in in IN cord-017772-zpf1xjqi 96 19 large large JJ cord-017772-zpf1xjqi 96 20 randomized randomized JJ cord-017772-zpf1xjqi 96 21 trials trial NNS cord-017772-zpf1xjqi 96 22 including include VBG cord-017772-zpf1xjqi 96 23 recombinant recombinant JJ cord-017772-zpf1xjqi 96 24 TF TF NNP cord-017772-zpf1xjqi 96 25 pathway pathway NN cord-017772-zpf1xjqi 96 26 inhibitors inhibitor NNS cord-017772-zpf1xjqi 96 27 and and CC cord-017772-zpf1xjqi 96 28 anti anti JJ cord-017772-zpf1xjqi 96 29 - - JJ cord-017772-zpf1xjqi 96 30 thrombin thrombin JJ cord-017772-zpf1xjqi 96 31 III III NNP cord-017772-zpf1xjqi 96 32 [ [ -LRB- cord-017772-zpf1xjqi 96 33 42 42 CD cord-017772-zpf1xjqi 96 34 , , , cord-017772-zpf1xjqi 96 35 43 43 CD cord-017772-zpf1xjqi 96 36 ] ] -RRB- cord-017772-zpf1xjqi 96 37 . . . cord-017772-zpf1xjqi 97 1 Early early JJ cord-017772-zpf1xjqi 97 2 studies study NNS cord-017772-zpf1xjqi 97 3 of of IN cord-017772-zpf1xjqi 97 4 activated activate VBN cord-017772-zpf1xjqi 97 5 protein protein NN cord-017772-zpf1xjqi 97 6 C C NNP cord-017772-zpf1xjqi 97 7 ( ( -LRB- cord-017772-zpf1xjqi 97 8 APC APC NNP cord-017772-zpf1xjqi 97 9 ) ) -RRB- cord-017772-zpf1xjqi 97 10 in in IN cord-017772-zpf1xjqi 97 11 patients patient NNS cord-017772-zpf1xjqi 97 12 with with IN cord-017772-zpf1xjqi 97 13 sepsis sepsis NN cord-017772-zpf1xjqi 97 14 showed show VBD cord-017772-zpf1xjqi 97 15 promise promise NN cord-017772-zpf1xjqi 97 16 , , , cord-017772-zpf1xjqi 97 17 especially especially RB cord-017772-zpf1xjqi 97 18 in in IN cord-017772-zpf1xjqi 97 19 the the DT cord-017772-zpf1xjqi 97 20 subset subset NN cord-017772-zpf1xjqi 97 21 of of IN cord-017772-zpf1xjqi 97 22 patients patient NNS cord-017772-zpf1xjqi 97 23 with with IN cord-017772-zpf1xjqi 97 24 DIC DIC NNP cord-017772-zpf1xjqi 97 25 [ [ -LRB- cord-017772-zpf1xjqi 97 26 44 44 CD cord-017772-zpf1xjqi 97 27 , , , cord-017772-zpf1xjqi 97 28 45 45 CD cord-017772-zpf1xjqi 97 29 ] ] -RRB- cord-017772-zpf1xjqi 97 30 . . . cord-017772-zpf1xjqi 98 1 However however RB cord-017772-zpf1xjqi 98 2 , , , cord-017772-zpf1xjqi 98 3 the the DT cord-017772-zpf1xjqi 98 4 recent recent JJ cord-017772-zpf1xjqi 98 5 PROWESS prowess NN cord-017772-zpf1xjqi 98 6 - - HYPH cord-017772-zpf1xjqi 98 7 SHOCK shock NN cord-017772-zpf1xjqi 98 8 trial trial NN cord-017772-zpf1xjqi 98 9 , , , cord-017772-zpf1xjqi 98 10 which which WDT cord-017772-zpf1xjqi 98 11 included include VBD cord-017772-zpf1xjqi 98 12 over over IN cord-017772-zpf1xjqi 98 13 1500 1500 CD cord-017772-zpf1xjqi 98 14 patients patient NNS cord-017772-zpf1xjqi 98 15 with with IN cord-017772-zpf1xjqi 98 16 septic septic JJ cord-017772-zpf1xjqi 98 17 shock shock NN cord-017772-zpf1xjqi 98 18 , , , cord-017772-zpf1xjqi 98 19 did do VBD cord-017772-zpf1xjqi 98 20 not not RB cord-017772-zpf1xjqi 98 21 identify identify VB cord-017772-zpf1xjqi 98 22 any any DT cord-017772-zpf1xjqi 98 23 benefit benefit NN cord-017772-zpf1xjqi 98 24 to to IN cord-017772-zpf1xjqi 98 25 the the DT cord-017772-zpf1xjqi 98 26 use use NN cord-017772-zpf1xjqi 98 27 of of IN cord-017772-zpf1xjqi 98 28 APC APC NNP cord-017772-zpf1xjqi 98 29 [ [ -LRB- cord-017772-zpf1xjqi 98 30 46 46 CD cord-017772-zpf1xjqi 98 31 ] ] -RRB- cord-017772-zpf1xjqi 98 32 . . . cord-017772-zpf1xjqi 99 1 A a DT cord-017772-zpf1xjqi 99 2 careful careful JJ cord-017772-zpf1xjqi 99 3 review review NN cord-017772-zpf1xjqi 99 4 of of IN cord-017772-zpf1xjqi 99 5 a a DT cord-017772-zpf1xjqi 99 6 patient patient NN cord-017772-zpf1xjqi 99 7 's 's POS cord-017772-zpf1xjqi 99 8 medication medication NN cord-017772-zpf1xjqi 99 9 list list NN cord-017772-zpf1xjqi 99 10 is be VBZ cord-017772-zpf1xjqi 99 11 an an DT cord-017772-zpf1xjqi 99 12 essential essential JJ cord-017772-zpf1xjqi 99 13 step step NN cord-017772-zpf1xjqi 99 14 in in IN cord-017772-zpf1xjqi 99 15 the the DT cord-017772-zpf1xjqi 99 16 evaluation evaluation NN cord-017772-zpf1xjqi 99 17 of of IN cord-017772-zpf1xjqi 99 18 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 99 19 in in IN cord-017772-zpf1xjqi 99 20 the the DT cord-017772-zpf1xjqi 99 21 ICU ICU NNP cord-017772-zpf1xjqi 99 22 . . . cord-017772-zpf1xjqi 100 1 Indeed indeed RB cord-017772-zpf1xjqi 100 2 , , , cord-017772-zpf1xjqi 100 3 medications medication NNS cord-017772-zpf1xjqi 100 4 may may MD cord-017772-zpf1xjqi 100 5 contribute contribute VB cord-017772-zpf1xjqi 100 6 to to IN cord-017772-zpf1xjqi 100 7 over over IN cord-017772-zpf1xjqi 100 8 10 10 CD cord-017772-zpf1xjqi 100 9 % % NN cord-017772-zpf1xjqi 100 10 of of IN cord-017772-zpf1xjqi 100 11 new new JJ cord-017772-zpf1xjqi 100 12 onset onset NN cord-017772-zpf1xjqi 100 13 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 100 14 in in IN cord-017772-zpf1xjqi 100 15 the the DT cord-017772-zpf1xjqi 100 16 critically critically RB cord-017772-zpf1xjqi 100 17 ill ill JJ cord-017772-zpf1xjqi 100 18 [ [ -LRB- cord-017772-zpf1xjqi 100 19 17 17 CD cord-017772-zpf1xjqi 100 20 ] ] -RRB- cord-017772-zpf1xjqi 100 21 . . . cord-017772-zpf1xjqi 101 1 Well well UH cord-017772-zpf1xjqi 101 2 over over IN cord-017772-zpf1xjqi 101 3 300 300 CD cord-017772-zpf1xjqi 101 4 drugs drug NNS cord-017772-zpf1xjqi 101 5 have have VBP cord-017772-zpf1xjqi 101 6 been be VBN cord-017772-zpf1xjqi 101 7 linked link VBN cord-017772-zpf1xjqi 101 8 to to IN cord-017772-zpf1xjqi 101 9 the the DT cord-017772-zpf1xjqi 101 10 development development NN cord-017772-zpf1xjqi 101 11 of of IN cord-017772-zpf1xjqi 101 12 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 101 13 [ [ -LRB- cord-017772-zpf1xjqi 101 14 47 47 CD cord-017772-zpf1xjqi 101 15 ] ] -RRB- cord-017772-zpf1xjqi 101 16 . . . cord-017772-zpf1xjqi 102 1 A a DT cord-017772-zpf1xjqi 102 2 list list NN cord-017772-zpf1xjqi 102 3 of of IN cord-017772-zpf1xjqi 102 4 notable notable JJ cord-017772-zpf1xjqi 102 5 drugs drug NNS cord-017772-zpf1xjqi 102 6 known know VBN cord-017772-zpf1xjqi 102 7 to to TO cord-017772-zpf1xjqi 102 8 cause cause VB cord-017772-zpf1xjqi 102 9 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 102 10 is be VBZ cord-017772-zpf1xjqi 102 11 provided provide VBN cord-017772-zpf1xjqi 102 12 in in IN cord-017772-zpf1xjqi 102 13 Table Table NNP cord-017772-zpf1xjqi 102 14 83.2 83.2 CD cord-017772-zpf1xjqi 102 15 . . . cord-017772-zpf1xjqi 103 1 Drug drug NN cord-017772-zpf1xjqi 103 2 - - HYPH cord-017772-zpf1xjqi 103 3 induced induce VBN cord-017772-zpf1xjqi 103 4 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 103 5 can can MD cord-017772-zpf1xjqi 103 6 be be VB cord-017772-zpf1xjqi 103 7 grouped group VBN cord-017772-zpf1xjqi 103 8 into into IN cord-017772-zpf1xjqi 103 9 two two CD cord-017772-zpf1xjqi 103 10 major major JJ cord-017772-zpf1xjqi 103 11 categories category NNS cord-017772-zpf1xjqi 103 12 : : : cord-017772-zpf1xjqi 103 13 drug drug NN cord-017772-zpf1xjqi 103 14 - - HYPH cord-017772-zpf1xjqi 103 15 induced induce VBN cord-017772-zpf1xjqi 103 16 non non JJ cord-017772-zpf1xjqi 103 17 - - JJ cord-017772-zpf1xjqi 103 18 immune immune JJ cord-017772-zpf1xjqi 103 19 Adapted adapt VBN cord-017772-zpf1xjqi 103 20 from from IN cord-017772-zpf1xjqi 103 21 Toh Toh NNP cord-017772-zpf1xjqi 103 22 [ [ -LRB- cord-017772-zpf1xjqi 103 23 37 37 CD cord-017772-zpf1xjqi 103 24 ] ] -RRB- cord-017772-zpf1xjqi 103 25 . . . cord-017772-zpf1xjqi 104 1 A a DT cord-017772-zpf1xjqi 104 2 score score NN cord-017772-zpf1xjqi 104 3 of of IN cord-017772-zpf1xjqi 104 4 > > XX cord-017772-zpf1xjqi 104 5 5 5 CD cord-017772-zpf1xjqi 104 6 is be VBZ cord-017772-zpf1xjqi 104 7 compatible compatible JJ cord-017772-zpf1xjqi 104 8 with with IN cord-017772-zpf1xjqi 104 9 DIC DIC NNP cord-017772-zpf1xjqi 104 10 , , , cord-017772-zpf1xjqi 104 11 scoring scoring NN cord-017772-zpf1xjqi 104 12 should should MD cord-017772-zpf1xjqi 104 13 be be VB cord-017772-zpf1xjqi 104 14 repeated repeat VBN cord-017772-zpf1xjqi 104 15 daily daily RB cord-017772-zpf1xjqi 104 16 . . . cord-017772-zpf1xjqi 105 1 A a DT cord-017772-zpf1xjqi 105 2 score score NN cord-017772-zpf1xjqi 105 3 < < XX cord-017772-zpf1xjqi 105 4 5 5 CD cord-017772-zpf1xjqi 105 5 is be VBZ cord-017772-zpf1xjqi 105 6 suggestive suggestive JJ cord-017772-zpf1xjqi 105 7 of of IN cord-017772-zpf1xjqi 105 8 non non JJ cord-017772-zpf1xjqi 105 9 - - JJ cord-017772-zpf1xjqi 105 10 overt overt JJ cord-017772-zpf1xjqi 105 11 DIC DIC NNP cord-017772-zpf1xjqi 105 12 , , , cord-017772-zpf1xjqi 105 13 scoring scoring NN cord-017772-zpf1xjqi 105 14 should should MD cord-017772-zpf1xjqi 105 15 be be VB cord-017772-zpf1xjqi 105 16 repeated repeat VBN cord-017772-zpf1xjqi 105 17 in in IN cord-017772-zpf1xjqi 105 18 the the DT cord-017772-zpf1xjqi 105 19 next next JJ cord-017772-zpf1xjqi 105 20 1 1 CD cord-017772-zpf1xjqi 105 21 - - SYM cord-017772-zpf1xjqi 105 22 2 2 CD cord-017772-zpf1xjqi 105 23 days day NNS cord-017772-zpf1xjqi 106 1 Data datum NNS cord-017772-zpf1xjqi 106 2 adapted adapt VBN cord-017772-zpf1xjqi 106 3 from from IN cord-017772-zpf1xjqi 106 4 Mitta Mitta NNP cord-017772-zpf1xjqi 106 5 [ [ -LRB- cord-017772-zpf1xjqi 106 6 51 51 CD cord-017772-zpf1xjqi 106 7 ] ] -RRB- cord-017772-zpf1xjqi 106 8 , , , cord-017772-zpf1xjqi 106 9 Reese Reese NNP cord-017772-zpf1xjqi 106 10 [ [ -LRB- cord-017772-zpf1xjqi 106 11 47 47 CD cord-017772-zpf1xjqi 106 12 ] ] -RRB- cord-017772-zpf1xjqi 106 13 , , , cord-017772-zpf1xjqi 106 14 and and CC cord-017772-zpf1xjqi 106 15 the the DT cord-017772-zpf1xjqi 106 16 University University NNP cord-017772-zpf1xjqi 106 17 of of IN cord-017772-zpf1xjqi 106 18 Oklahoma Oklahoma NNP cord-017772-zpf1xjqi 106 19 web web NN cord-017772-zpf1xjqi 106 20 resource resource NN cord-017772-zpf1xjqi 106 21 https://ouhsc.edu/platelets/ditp.html https://ouhsc.edu/platelets/ditp.html ADD cord-017772-zpf1xjqi 106 22 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 106 23 and and CC cord-017772-zpf1xjqi 106 24 drug drug NN cord-017772-zpf1xjqi 106 25 - - HYPH cord-017772-zpf1xjqi 106 26 induced induce VBN cord-017772-zpf1xjqi 106 27 immune immune JJ cord-017772-zpf1xjqi 106 28 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 106 29 [ [ -LRB- cord-017772-zpf1xjqi 106 30 48 48 CD cord-017772-zpf1xjqi 106 31 ] ] -RRB- cord-017772-zpf1xjqi 106 32 . . . cord-017772-zpf1xjqi 107 1 Drug drug NN cord-017772-zpf1xjqi 107 2 - - HYPH cord-017772-zpf1xjqi 107 3 induced induce VBN cord-017772-zpf1xjqi 107 4 non non JJ cord-017772-zpf1xjqi 107 5 - - JJ cord-017772-zpf1xjqi 107 6 immune immune JJ cord-017772-zpf1xjqi 107 7 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 107 8 is be VBZ cord-017772-zpf1xjqi 107 9 far far RB cord-017772-zpf1xjqi 107 10 more more RBR cord-017772-zpf1xjqi 107 11 common common JJ cord-017772-zpf1xjqi 107 12 and and CC cord-017772-zpf1xjqi 107 13 is be VBZ cord-017772-zpf1xjqi 107 14 characterized characterize VBN cord-017772-zpf1xjqi 107 15 by by IN cord-017772-zpf1xjqi 107 16 dose dose NN cord-017772-zpf1xjqi 107 17 - - HYPH cord-017772-zpf1xjqi 107 18 dependent dependent JJ cord-017772-zpf1xjqi 107 19 suppression suppression NN cord-017772-zpf1xjqi 107 20 of of IN cord-017772-zpf1xjqi 107 21 bone bone NN cord-017772-zpf1xjqi 107 22 marrow marrow NN cord-017772-zpf1xjqi 107 23 platelet platelet NN cord-017772-zpf1xjqi 107 24 production production NN cord-017772-zpf1xjqi 107 25 . . . cord-017772-zpf1xjqi 108 1 Representative representative JJ cord-017772-zpf1xjqi 108 2 medications medication NNS cord-017772-zpf1xjqi 108 3 include include VBP cord-017772-zpf1xjqi 108 4 linezolid linezolid NNP cord-017772-zpf1xjqi 108 5 , , , cord-017772-zpf1xjqi 108 6 chemotherapeutics chemotherapeutic NNS cord-017772-zpf1xjqi 108 7 , , , cord-017772-zpf1xjqi 108 8 and and CC cord-017772-zpf1xjqi 108 9 immunosuppressive immunosuppressive JJ cord-017772-zpf1xjqi 108 10 agents agent NNS cord-017772-zpf1xjqi 108 11 like like IN cord-017772-zpf1xjqi 108 12 azathioprine azathioprine NN cord-017772-zpf1xjqi 108 13 [ [ -LRB- cord-017772-zpf1xjqi 108 14 49 49 CD cord-017772-zpf1xjqi 108 15 ] ] -RRB- cord-017772-zpf1xjqi 108 16 . . . cord-017772-zpf1xjqi 109 1 Drug drug NN cord-017772-zpf1xjqi 109 2 - - HYPH cord-017772-zpf1xjqi 109 3 induced induce VBN cord-017772-zpf1xjqi 109 4 immune immune JJ cord-017772-zpf1xjqi 109 5 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 109 6 occurs occur VBZ cord-017772-zpf1xjqi 109 7 through through IN cord-017772-zpf1xjqi 109 8 a a DT cord-017772-zpf1xjqi 109 9 variety variety NN cord-017772-zpf1xjqi 109 10 of of IN cord-017772-zpf1xjqi 109 11 mechanisms mechanism NNS cord-017772-zpf1xjqi 109 12 . . . cord-017772-zpf1xjqi 110 1 Rarely rarely RB cord-017772-zpf1xjqi 110 2 , , , cord-017772-zpf1xjqi 110 3 medications medication NNS cord-017772-zpf1xjqi 110 4 may may MD cord-017772-zpf1xjqi 110 5 induce induce VB cord-017772-zpf1xjqi 110 6 autoantibodies autoantibody NNS cord-017772-zpf1xjqi 110 7 that that WDT cord-017772-zpf1xjqi 110 8 destroy destroy VBP cord-017772-zpf1xjqi 110 9 host host NN cord-017772-zpf1xjqi 110 10 platelets platelet NNS cord-017772-zpf1xjqi 110 11 in in IN cord-017772-zpf1xjqi 110 12 the the DT cord-017772-zpf1xjqi 110 13 absence absence NN cord-017772-zpf1xjqi 110 14 of of IN cord-017772-zpf1xjqi 110 15 the the DT cord-017772-zpf1xjqi 110 16 drug drug NN cord-017772-zpf1xjqi 110 17 . . . cord-017772-zpf1xjqi 111 1 Examples example NNS cord-017772-zpf1xjqi 111 2 include include VBP cord-017772-zpf1xjqi 111 3 gold gold NN cord-017772-zpf1xjqi 111 4 salts salt NNS cord-017772-zpf1xjqi 111 5 and and CC cord-017772-zpf1xjqi 111 6 procainamide procainamide VB cord-017772-zpf1xjqi 111 7 [ [ -LRB- cord-017772-zpf1xjqi 111 8 50 50 CD cord-017772-zpf1xjqi 111 9 ] ] -RRB- cord-017772-zpf1xjqi 111 10 . . . cord-017772-zpf1xjqi 112 1 More more RBR cord-017772-zpf1xjqi 112 2 commonly commonly RB cord-017772-zpf1xjqi 112 3 , , , cord-017772-zpf1xjqi 112 4 a a DT cord-017772-zpf1xjqi 112 5 drug drug NN cord-017772-zpf1xjqi 112 6 will will MD cord-017772-zpf1xjqi 112 7 induce induce VB cord-017772-zpf1xjqi 112 8 the the DT cord-017772-zpf1xjqi 112 9 production production NN cord-017772-zpf1xjqi 112 10 of of IN cord-017772-zpf1xjqi 112 11 antibodies antibody NNS cord-017772-zpf1xjqi 112 12 that that WDT cord-017772-zpf1xjqi 112 13 bind bind VBP cord-017772-zpf1xjqi 112 14 to to IN cord-017772-zpf1xjqi 112 15 an an DT cord-017772-zpf1xjqi 112 16 epitope epitope NN cord-017772-zpf1xjqi 112 17 on on IN cord-017772-zpf1xjqi 112 18 a a DT cord-017772-zpf1xjqi 112 19 platelet platelet NN cord-017772-zpf1xjqi 112 20 glycoprotein glycoprotein NN cord-017772-zpf1xjqi 112 21 in in IN cord-017772-zpf1xjqi 112 22 the the DT cord-017772-zpf1xjqi 112 23 presence presence NN cord-017772-zpf1xjqi 112 24 of of IN cord-017772-zpf1xjqi 112 25 the the DT cord-017772-zpf1xjqi 112 26 medication medication NN cord-017772-zpf1xjqi 112 27 . . . cord-017772-zpf1xjqi 113 1 Many many JJ cord-017772-zpf1xjqi 113 2 antibiotics antibiotic NNS cord-017772-zpf1xjqi 113 3 including include VBG cord-017772-zpf1xjqi 113 4 aztreonam aztreonam NNP cord-017772-zpf1xjqi 113 5 , , , cord-017772-zpf1xjqi 113 6 piperacillin piperacillin NNP cord-017772-zpf1xjqi 113 7 , , , cord-017772-zpf1xjqi 113 8 sulfonamides sulfonamide NNS cord-017772-zpf1xjqi 113 9 , , , cord-017772-zpf1xjqi 113 10 and and CC cord-017772-zpf1xjqi 113 11 vancomycin vancomycin NN cord-017772-zpf1xjqi 113 12 likely likely RB cord-017772-zpf1xjqi 113 13 act act VBP cord-017772-zpf1xjqi 113 14 through through IN cord-017772-zpf1xjqi 113 15 this this DT cord-017772-zpf1xjqi 113 16 mechanism mechanism NN cord-017772-zpf1xjqi 113 17 [ [ -LRB- cord-017772-zpf1xjqi 113 18 51 51 CD cord-017772-zpf1xjqi 113 19 ] ] -RRB- cord-017772-zpf1xjqi 113 20 . . . cord-017772-zpf1xjqi 114 1 Heparin heparin NN cord-017772-zpf1xjqi 114 2 - - HYPH cord-017772-zpf1xjqi 114 3 induced induce VBN cord-017772-zpf1xjqi 114 4 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 114 5 ( ( -LRB- cord-017772-zpf1xjqi 114 6 HIT hit NN cord-017772-zpf1xjqi 114 7 ) ) -RRB- cord-017772-zpf1xjqi 114 8 is be VBZ cord-017772-zpf1xjqi 114 9 a a DT cord-017772-zpf1xjqi 114 10 particularly particularly RB cord-017772-zpf1xjqi 114 11 important important JJ cord-017772-zpf1xjqi 114 12 example example NN cord-017772-zpf1xjqi 114 13 and and CC cord-017772-zpf1xjqi 114 14 is be VBZ cord-017772-zpf1xjqi 114 15 reviewed review VBN cord-017772-zpf1xjqi 114 16 in in IN cord-017772-zpf1xjqi 114 17 detail detail NN cord-017772-zpf1xjqi 114 18 below below RB cord-017772-zpf1xjqi 114 19 . . . cord-017772-zpf1xjqi 115 1 Finally finally RB cord-017772-zpf1xjqi 115 2 , , , cord-017772-zpf1xjqi 115 3 antiplatelet antiplatelet NN cord-017772-zpf1xjqi 115 4 agents agent NNS cord-017772-zpf1xjqi 115 5 such such JJ cord-017772-zpf1xjqi 115 6 as as IN cord-017772-zpf1xjqi 115 7 eptifibatide eptifibatide NNP cord-017772-zpf1xjqi 115 8 used use VBN cord-017772-zpf1xjqi 115 9 in in IN cord-017772-zpf1xjqi 115 10 the the DT cord-017772-zpf1xjqi 115 11 treatment treatment NN cord-017772-zpf1xjqi 115 12 of of IN cord-017772-zpf1xjqi 115 13 acute acute JJ cord-017772-zpf1xjqi 115 14 coronary coronary JJ cord-017772-zpf1xjqi 115 15 syndrome syndrome NN cord-017772-zpf1xjqi 115 16 facilitate facilitate VBP cord-017772-zpf1xjqi 115 17 antibody antibody NN cord-017772-zpf1xjqi 115 18 - - HYPH cord-017772-zpf1xjqi 115 19 mediated mediate VBN cord-017772-zpf1xjqi 115 20 destruction destruction NN cord-017772-zpf1xjqi 115 21 of of IN cord-017772-zpf1xjqi 115 22 platelets platelet NNS cord-017772-zpf1xjqi 115 23 through through IN cord-017772-zpf1xjqi 115 24 their -PRON- PRP$ cord-017772-zpf1xjqi 115 25 binding binding NN cord-017772-zpf1xjqi 115 26 of of IN cord-017772-zpf1xjqi 115 27 glycoprotein glycoprotein NN cord-017772-zpf1xjqi 115 28 IIb IIb NNP cord-017772-zpf1xjqi 115 29 / / SYM cord-017772-zpf1xjqi 115 30 IIIa iiia NN cord-017772-zpf1xjqi 115 31 [ [ -LRB- cord-017772-zpf1xjqi 115 32 4 4 CD cord-017772-zpf1xjqi 115 33 ] ] -RRB- cord-017772-zpf1xjqi 115 34 . . . cord-017772-zpf1xjqi 116 1 Drug drug NN cord-017772-zpf1xjqi 116 2 - - HYPH cord-017772-zpf1xjqi 116 3 induced induce VBN cord-017772-zpf1xjqi 116 4 immune immune NN cord-017772-zpf1xjqi 116 5 - - HYPH cord-017772-zpf1xjqi 116 6 mediated mediate VBN cord-017772-zpf1xjqi 116 7 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 116 8 typically typically RB cord-017772-zpf1xjqi 116 9 occurs occur VBZ cord-017772-zpf1xjqi 116 10 5 5 CD cord-017772-zpf1xjqi 116 11 - - SYM cord-017772-zpf1xjqi 116 12 7 7 CD cord-017772-zpf1xjqi 116 13 days day NNS cord-017772-zpf1xjqi 116 14 after after IN cord-017772-zpf1xjqi 116 15 exposure exposure NN cord-017772-zpf1xjqi 116 16 to to IN cord-017772-zpf1xjqi 116 17 the the DT cord-017772-zpf1xjqi 116 18 causative causative JJ cord-017772-zpf1xjqi 116 19 medication medication NN cord-017772-zpf1xjqi 116 20 . . . cord-017772-zpf1xjqi 117 1 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 117 2 is be VBZ cord-017772-zpf1xjqi 117 3 often often RB cord-017772-zpf1xjqi 117 4 severe severe JJ cord-017772-zpf1xjqi 117 5 with with IN cord-017772-zpf1xjqi 117 6 platelet platelet NN cord-017772-zpf1xjqi 117 7 counts count NNS cord-017772-zpf1xjqi 117 8 falling fall VBG cord-017772-zpf1xjqi 117 9 to to IN cord-017772-zpf1xjqi 117 10 < < XX cord-017772-zpf1xjqi 117 11 20 20 CD cord-017772-zpf1xjqi 117 12 x x SYM cord-017772-zpf1xjqi 117 13 10 10 CD cord-017772-zpf1xjqi 117 14 9 9 CD cord-017772-zpf1xjqi 117 15 cells cell NNS cord-017772-zpf1xjqi 117 16 / / SYM cord-017772-zpf1xjqi 117 17 L. L. NNP cord-017772-zpf1xjqi 117 18 Mucocutaneous Mucocutaneous NNP cord-017772-zpf1xjqi 117 19 bleeding bleed VBG cord-017772-zpf1xjqi 117 20 and and CC cord-017772-zpf1xjqi 117 21 systemic systemic JJ cord-017772-zpf1xjqi 117 22 symptoms symptom NNS cord-017772-zpf1xjqi 117 23 may may MD cord-017772-zpf1xjqi 117 24 be be VB cord-017772-zpf1xjqi 117 25 present present JJ cord-017772-zpf1xjqi 117 26 [ [ -LRB- cord-017772-zpf1xjqi 117 27 48 48 CD cord-017772-zpf1xjqi 117 28 ] ] -RRB- cord-017772-zpf1xjqi 117 29 . . . cord-017772-zpf1xjqi 118 1 The the DT cord-017772-zpf1xjqi 118 2 diagnosis diagnosis NN cord-017772-zpf1xjqi 118 3 requires require VBZ cord-017772-zpf1xjqi 118 4 a a DT cord-017772-zpf1xjqi 118 5 high high JJ cord-017772-zpf1xjqi 118 6 index index NN cord-017772-zpf1xjqi 118 7 of of IN cord-017772-zpf1xjqi 118 8 suspicion suspicion NN cord-017772-zpf1xjqi 118 9 given give VBN cord-017772-zpf1xjqi 118 10 the the DT cord-017772-zpf1xjqi 118 11 lag lag NN cord-017772-zpf1xjqi 118 12 between between IN cord-017772-zpf1xjqi 118 13 when when WRB cord-017772-zpf1xjqi 118 14 a a DT cord-017772-zpf1xjqi 118 15 drug drug NN cord-017772-zpf1xjqi 118 16 is be VBZ cord-017772-zpf1xjqi 118 17 started start VBN cord-017772-zpf1xjqi 118 18 and and CC cord-017772-zpf1xjqi 118 19 the the DT cord-017772-zpf1xjqi 118 20 subsequent subsequent JJ cord-017772-zpf1xjqi 118 21 fall fall NN cord-017772-zpf1xjqi 118 22 in in IN cord-017772-zpf1xjqi 118 23 platelet platelet NN cord-017772-zpf1xjqi 118 24 count count NN cord-017772-zpf1xjqi 118 25 . . . cord-017772-zpf1xjqi 119 1 Identifying identify VBG cord-017772-zpf1xjqi 119 2 drug drug NN cord-017772-zpf1xjqi 119 3 - - HYPH cord-017772-zpf1xjqi 119 4 dependent dependent JJ cord-017772-zpf1xjqi 119 5 platelet platelet NN cord-017772-zpf1xjqi 119 6 reactive reactive JJ cord-017772-zpf1xjqi 119 7 antibodies antibody NNS cord-017772-zpf1xjqi 119 8 helps help VBZ cord-017772-zpf1xjqi 119 9 confirm confirm VB cord-017772-zpf1xjqi 119 10 the the DT cord-017772-zpf1xjqi 119 11 diagnosis diagnosis NN cord-017772-zpf1xjqi 119 12 ; ; : cord-017772-zpf1xjqi 119 13 however however RB cord-017772-zpf1xjqi 119 14 , , , cord-017772-zpf1xjqi 119 15 testing testing NN cord-017772-zpf1xjqi 119 16 is be VBZ cord-017772-zpf1xjqi 119 17 time time NN cord-017772-zpf1xjqi 119 18 consuming consume VBG cord-017772-zpf1xjqi 119 19 and and CC cord-017772-zpf1xjqi 119 20 available available JJ cord-017772-zpf1xjqi 119 21 at at IN cord-017772-zpf1xjqi 119 22 a a DT cord-017772-zpf1xjqi 119 23 limited limited JJ cord-017772-zpf1xjqi 119 24 number number NN cord-017772-zpf1xjqi 119 25 of of IN cord-017772-zpf1xjqi 119 26 centers center NNS cord-017772-zpf1xjqi 119 27 . . . cord-017772-zpf1xjqi 120 1 Treatment treatment NN cord-017772-zpf1xjqi 120 2 is be VBZ cord-017772-zpf1xjqi 120 3 focused focus VBN cord-017772-zpf1xjqi 120 4 on on IN cord-017772-zpf1xjqi 120 5 the the DT cord-017772-zpf1xjqi 120 6 identification identification NN cord-017772-zpf1xjqi 120 7 and and CC cord-017772-zpf1xjqi 120 8 removal removal NN cord-017772-zpf1xjqi 120 9 of of IN cord-017772-zpf1xjqi 120 10 the the DT cord-017772-zpf1xjqi 120 11 causative causative JJ cord-017772-zpf1xjqi 120 12 medication medication NN cord-017772-zpf1xjqi 120 13 . . . cord-017772-zpf1xjqi 121 1 When when WRB cord-017772-zpf1xjqi 121 2 the the DT cord-017772-zpf1xjqi 121 3 offending offending JJ cord-017772-zpf1xjqi 121 4 drug drug NN cord-017772-zpf1xjqi 121 5 is be VBZ cord-017772-zpf1xjqi 121 6 removed remove VBN cord-017772-zpf1xjqi 121 7 , , , cord-017772-zpf1xjqi 121 8 platelets platelet NNS cord-017772-zpf1xjqi 121 9 typically typically RB cord-017772-zpf1xjqi 121 10 begin begin VBP cord-017772-zpf1xjqi 121 11 to to TO cord-017772-zpf1xjqi 121 12 improve improve VB cord-017772-zpf1xjqi 121 13 in in IN cord-017772-zpf1xjqi 121 14 1 1 CD cord-017772-zpf1xjqi 121 15 - - SYM cord-017772-zpf1xjqi 121 16 2 2 CD cord-017772-zpf1xjqi 121 17 days day NNS cord-017772-zpf1xjqi 121 18 . . . cord-017772-zpf1xjqi 122 1 The the DT cord-017772-zpf1xjqi 122 2 role role NN cord-017772-zpf1xjqi 122 3 of of IN cord-017772-zpf1xjqi 122 4 steroids steroid NNS cord-017772-zpf1xjqi 122 5 and and CC cord-017772-zpf1xjqi 122 6 intravenous intravenous JJ cord-017772-zpf1xjqi 122 7 immunoglobulin immunoglobulin NN cord-017772-zpf1xjqi 122 8 in in IN cord-017772-zpf1xjqi 122 9 the the DT cord-017772-zpf1xjqi 122 10 treatment treatment NN cord-017772-zpf1xjqi 122 11 of of IN cord-017772-zpf1xjqi 122 12 refractory refractory JJ cord-017772-zpf1xjqi 122 13 drug drug NN cord-017772-zpf1xjqi 122 14 - - HYPH cord-017772-zpf1xjqi 122 15 induced induce VBN cord-017772-zpf1xjqi 122 16 immune immune JJ cord-017772-zpf1xjqi 122 17 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 122 18 is be VBZ cord-017772-zpf1xjqi 122 19 controversial controversial JJ cord-017772-zpf1xjqi 122 20 [ [ -LRB- cord-017772-zpf1xjqi 122 21 50 50 CD cord-017772-zpf1xjqi 122 22 ] ] -RRB- cord-017772-zpf1xjqi 122 23 . . . cord-017772-zpf1xjqi 123 1 A a DT cord-017772-zpf1xjqi 123 2 helpful helpful JJ cord-017772-zpf1xjqi 123 3 website website NN cord-017772-zpf1xjqi 123 4 , , , cord-017772-zpf1xjqi 123 5 https://ouhsc.edu/platelets/ditp.html https://ouhsc.edu/platelets/ditp.html ADD cord-017772-zpf1xjqi 123 6 , , , cord-017772-zpf1xjqi 123 7 includes include VBZ cord-017772-zpf1xjqi 123 8 a a DT cord-017772-zpf1xjqi 123 9 curated curated JJ cord-017772-zpf1xjqi 123 10 list list NN cord-017772-zpf1xjqi 123 11 of of IN cord-017772-zpf1xjqi 123 12 all all DT cord-017772-zpf1xjqi 123 13 drugs drug NNS cord-017772-zpf1xjqi 123 14 associated associate VBN cord-017772-zpf1xjqi 123 15 with with IN cord-017772-zpf1xjqi 123 16 drugdependent drugdependent NN cord-017772-zpf1xjqi 123 17 platelet platelet NN cord-017772-zpf1xjqi 123 18 - - HYPH cord-017772-zpf1xjqi 123 19 reactive reactive JJ cord-017772-zpf1xjqi 123 20 antibodies antibody NNS cord-017772-zpf1xjqi 123 21 identified identify VBN cord-017772-zpf1xjqi 123 22 by by IN cord-017772-zpf1xjqi 123 23 the the DT cord-017772-zpf1xjqi 123 24 BloodCenter BloodCenter NNP cord-017772-zpf1xjqi 123 25 of of IN cord-017772-zpf1xjqi 123 26 Wisconsin Wisconsin NNP cord-017772-zpf1xjqi 123 27 dating date VBG cord-017772-zpf1xjqi 123 28 back back RB cord-017772-zpf1xjqi 123 29 to to IN cord-017772-zpf1xjqi 123 30 1995 1995 CD cord-017772-zpf1xjqi 123 31 . . . cord-017772-zpf1xjqi 124 1 HIT HIT NNP cord-017772-zpf1xjqi 124 2 is be VBZ cord-017772-zpf1xjqi 124 3 caused cause VBN cord-017772-zpf1xjqi 124 4 by by IN cord-017772-zpf1xjqi 124 5 the the DT cord-017772-zpf1xjqi 124 6 production production NN cord-017772-zpf1xjqi 124 7 of of IN cord-017772-zpf1xjqi 124 8 host host NN cord-017772-zpf1xjqi 124 9 IgG IgG NNP cord-017772-zpf1xjqi 124 10 antibodies antibody NNS cord-017772-zpf1xjqi 124 11 against against IN cord-017772-zpf1xjqi 124 12 platelet platelet NN cord-017772-zpf1xjqi 124 13 factor factor NN cord-017772-zpf1xjqi 124 14 4 4 CD cord-017772-zpf1xjqi 124 15 ( ( -LRB- cord-017772-zpf1xjqi 124 16 PF4)-heparin pf4)-heparin NN cord-017772-zpf1xjqi 124 17 complexes complex NNS cord-017772-zpf1xjqi 124 18 . . . cord-017772-zpf1xjqi 125 1 The the DT cord-017772-zpf1xjqi 125 2 Fc Fc NNP cord-017772-zpf1xjqi 125 3 domain domain NN cord-017772-zpf1xjqi 125 4 of of IN cord-017772-zpf1xjqi 125 5 these these DT cord-017772-zpf1xjqi 125 6 immune immune JJ cord-017772-zpf1xjqi 125 7 complexes complex NNS cord-017772-zpf1xjqi 125 8 binds bind VBZ cord-017772-zpf1xjqi 125 9 to to IN cord-017772-zpf1xjqi 125 10 the the DT cord-017772-zpf1xjqi 125 11 platelet platelet NN cord-017772-zpf1xjqi 125 12 FCγ fcγ JJ cord-017772-zpf1xjqi 125 13 RIIa RIIa NNS cord-017772-zpf1xjqi 125 14 receptor receptor NN cord-017772-zpf1xjqi 125 15 causing cause VBG cord-017772-zpf1xjqi 125 16 platelet platelet NN cord-017772-zpf1xjqi 125 17 aggregation aggregation NN cord-017772-zpf1xjqi 125 18 , , , cord-017772-zpf1xjqi 125 19 platelet platelet NN cord-017772-zpf1xjqi 125 20 activation activation NN cord-017772-zpf1xjqi 125 21 , , , cord-017772-zpf1xjqi 125 22 and and CC cord-017772-zpf1xjqi 125 23 eventual eventual JJ cord-017772-zpf1xjqi 125 24 thrombin thrombin NN cord-017772-zpf1xjqi 125 25 formation formation NN cord-017772-zpf1xjqi 125 26 [ [ -LRB- cord-017772-zpf1xjqi 125 27 52 52 CD cord-017772-zpf1xjqi 125 28 ] ] -RRB- cord-017772-zpf1xjqi 125 29 . . . cord-017772-zpf1xjqi 126 1 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 126 2 is be VBZ cord-017772-zpf1xjqi 126 3 caused cause VBN cord-017772-zpf1xjqi 126 4 by by IN cord-017772-zpf1xjqi 126 5 intravascular intravascular JJ cord-017772-zpf1xjqi 126 6 platelet platelet NN cord-017772-zpf1xjqi 126 7 consumption consumption NN cord-017772-zpf1xjqi 126 8 . . . cord-017772-zpf1xjqi 127 1 While while IN cord-017772-zpf1xjqi 127 2 a a DT cord-017772-zpf1xjqi 127 3 diagnosis diagnosis NN cord-017772-zpf1xjqi 127 4 of of IN cord-017772-zpf1xjqi 127 5 HIT HIT NNP cord-017772-zpf1xjqi 127 6 is be VBZ cord-017772-zpf1xjqi 127 7 frequently frequently RB cord-017772-zpf1xjqi 127 8 considered consider VBN cord-017772-zpf1xjqi 127 9 for for IN cord-017772-zpf1xjqi 127 10 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 127 11 patients patient NNS cord-017772-zpf1xjqi 127 12 in in IN cord-017772-zpf1xjqi 127 13 the the DT cord-017772-zpf1xjqi 127 14 ICU ICU NNP cord-017772-zpf1xjqi 127 15 , , , cord-017772-zpf1xjqi 127 16 it -PRON- PRP cord-017772-zpf1xjqi 127 17 is be VBZ cord-017772-zpf1xjqi 127 18 relatively relatively RB cord-017772-zpf1xjqi 127 19 uncommon uncommon JJ cord-017772-zpf1xjqi 127 20 . . . cord-017772-zpf1xjqi 128 1 For for IN cord-017772-zpf1xjqi 128 2 patients patient NNS cord-017772-zpf1xjqi 128 3 in in IN cord-017772-zpf1xjqi 128 4 the the DT cord-017772-zpf1xjqi 128 5 medical medical JJ cord-017772-zpf1xjqi 128 6 ICU ICU NNP cord-017772-zpf1xjqi 128 7 , , , cord-017772-zpf1xjqi 128 8 the the DT cord-017772-zpf1xjqi 128 9 incidence incidence NN cord-017772-zpf1xjqi 128 10 may may MD cord-017772-zpf1xjqi 128 11 be be VB cord-017772-zpf1xjqi 128 12 as as RB cord-017772-zpf1xjqi 128 13 low low JJ cord-017772-zpf1xjqi 128 14 as as IN cord-017772-zpf1xjqi 128 15 0.02 0.02 CD cord-017772-zpf1xjqi 128 16 % % NN cord-017772-zpf1xjqi 128 17 [ [ -LRB- cord-017772-zpf1xjqi 128 18 53 53 CD cord-017772-zpf1xjqi 128 19 ] ] -RRB- cord-017772-zpf1xjqi 128 20 . . . cord-017772-zpf1xjqi 129 1 The the DT cord-017772-zpf1xjqi 129 2 biggest big JJS cord-017772-zpf1xjqi 129 3 risk risk NN cord-017772-zpf1xjqi 129 4 factors factor NNS cord-017772-zpf1xjqi 129 5 for for IN cord-017772-zpf1xjqi 129 6 HIT hit NN cord-017772-zpf1xjqi 129 7 include include VBP cord-017772-zpf1xjqi 129 8 the the DT cord-017772-zpf1xjqi 129 9 use use NN cord-017772-zpf1xjqi 129 10 of of IN cord-017772-zpf1xjqi 129 11 unfractionated unfractionated JJ cord-017772-zpf1xjqi 129 12 heparin heparin NN cord-017772-zpf1xjqi 129 13 and and CC cord-017772-zpf1xjqi 129 14 cardiac cardiac JJ cord-017772-zpf1xjqi 129 15 surgery surgery NN cord-017772-zpf1xjqi 129 16 . . . cord-017772-zpf1xjqi 130 1 In in IN cord-017772-zpf1xjqi 130 2 these these DT cord-017772-zpf1xjqi 130 3 settings setting NNS cord-017772-zpf1xjqi 130 4 , , , cord-017772-zpf1xjqi 130 5 the the DT cord-017772-zpf1xjqi 130 6 incidence incidence NN cord-017772-zpf1xjqi 130 7 increases increase VBZ cord-017772-zpf1xjqi 130 8 up up IN cord-017772-zpf1xjqi 130 9 to to TO cord-017772-zpf1xjqi 130 10 3 3 CD cord-017772-zpf1xjqi 130 11 % % NN cord-017772-zpf1xjqi 130 12 [ [ -LRB- cord-017772-zpf1xjqi 130 13 53 53 CD cord-017772-zpf1xjqi 130 14 ] ] -RRB- cord-017772-zpf1xjqi 130 15 . . . cord-017772-zpf1xjqi 131 1 HIT HIT NNP cord-017772-zpf1xjqi 131 2 is be VBZ cord-017772-zpf1xjqi 131 3 unique unique JJ cord-017772-zpf1xjqi 131 4 among among IN cord-017772-zpf1xjqi 131 5 the the DT cord-017772-zpf1xjqi 131 6 common common JJ cord-017772-zpf1xjqi 131 7 causes cause NNS cord-017772-zpf1xjqi 131 8 of of IN cord-017772-zpf1xjqi 131 9 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 131 10 in in IN cord-017772-zpf1xjqi 131 11 the the DT cord-017772-zpf1xjqi 131 12 critically critically RB cord-017772-zpf1xjqi 131 13 ill ill JJ cord-017772-zpf1xjqi 131 14 in in IN cord-017772-zpf1xjqi 131 15 that that IN cord-017772-zpf1xjqi 131 16 it -PRON- PRP cord-017772-zpf1xjqi 131 17 is be VBZ cord-017772-zpf1xjqi 131 18 characterized characterize VBN cord-017772-zpf1xjqi 131 19 by by IN cord-017772-zpf1xjqi 131 20 thrombosis thrombosis NN cord-017772-zpf1xjqi 131 21 rather rather RB cord-017772-zpf1xjqi 131 22 than than IN cord-017772-zpf1xjqi 131 23 bleeding bleed VBG cord-017772-zpf1xjqi 131 24 . . . cord-017772-zpf1xjqi 132 1 Over over IN cord-017772-zpf1xjqi 132 2 50 50 CD cord-017772-zpf1xjqi 132 3 % % NN cord-017772-zpf1xjqi 132 4 of of IN cord-017772-zpf1xjqi 132 5 patients patient NNS cord-017772-zpf1xjqi 132 6 with with IN cord-017772-zpf1xjqi 132 7 HIT hit NN cord-017772-zpf1xjqi 132 8 develop develop VBP cord-017772-zpf1xjqi 132 9 thrombosis thrombosis NN cord-017772-zpf1xjqi 132 10 , , , cord-017772-zpf1xjqi 132 11 most most RBS cord-017772-zpf1xjqi 132 12 commonly commonly RB cord-017772-zpf1xjqi 132 13 in in IN cord-017772-zpf1xjqi 132 14 the the DT cord-017772-zpf1xjqi 132 15 deep deep JJ cord-017772-zpf1xjqi 132 16 veins vein NNS cord-017772-zpf1xjqi 132 17 of of IN cord-017772-zpf1xjqi 132 18 the the DT cord-017772-zpf1xjqi 132 19 extremities extremity NNS cord-017772-zpf1xjqi 132 20 and and CC cord-017772-zpf1xjqi 132 21 pulmonary pulmonary JJ cord-017772-zpf1xjqi 132 22 arteries artery NNS cord-017772-zpf1xjqi 132 23 [ [ -LRB- cord-017772-zpf1xjqi 132 24 53 53 CD cord-017772-zpf1xjqi 132 25 , , , cord-017772-zpf1xjqi 132 26 54 54 CD cord-017772-zpf1xjqi 132 27 ] ] -RRB- cord-017772-zpf1xjqi 132 28 . . . cord-017772-zpf1xjqi 133 1 HIT hit VB cord-017772-zpf1xjqi 133 2 can can MD cord-017772-zpf1xjqi 133 3 also also RB cord-017772-zpf1xjqi 133 4 cause cause VB cord-017772-zpf1xjqi 133 5 arterial arterial JJ cord-017772-zpf1xjqi 133 6 thrombosis thrombosis NN cord-017772-zpf1xjqi 133 7 , , , cord-017772-zpf1xjqi 133 8 thrombosis thrombosis NN cord-017772-zpf1xjqi 133 9 in in IN cord-017772-zpf1xjqi 133 10 unusual unusual JJ cord-017772-zpf1xjqi 133 11 venous venous JJ cord-017772-zpf1xjqi 133 12 structures structure NNS cord-017772-zpf1xjqi 133 13 ( ( -LRB- cord-017772-zpf1xjqi 133 14 e.g. e.g. IN cord-017772-zpf1xjqi 133 15 mesenteric mesenteric JJ cord-017772-zpf1xjqi 133 16 vessels vessel NNS cord-017772-zpf1xjqi 133 17 ) ) -RRB- cord-017772-zpf1xjqi 133 18 , , , cord-017772-zpf1xjqi 133 19 and and CC cord-017772-zpf1xjqi 133 20 myocardial myocardial JJ cord-017772-zpf1xjqi 133 21 infarction infarction NN cord-017772-zpf1xjqi 133 22 [ [ -LRB- cord-017772-zpf1xjqi 133 23 54 54 CD cord-017772-zpf1xjqi 133 24 ] ] -RRB- cord-017772-zpf1xjqi 133 25 . . . cord-017772-zpf1xjqi 134 1 HIT hit VB cord-017772-zpf1xjqi 134 2 should should MD cord-017772-zpf1xjqi 134 3 be be VB cord-017772-zpf1xjqi 134 4 suspected suspect VBN cord-017772-zpf1xjqi 134 5 when when WRB cord-017772-zpf1xjqi 134 6 platelet platelet NN cord-017772-zpf1xjqi 134 7 counts count NNS cord-017772-zpf1xjqi 134 8 fall fall VBP cord-017772-zpf1xjqi 134 9 by by IN cord-017772-zpf1xjqi 134 10 at at RB cord-017772-zpf1xjqi 134 11 least least RBS cord-017772-zpf1xjqi 134 12 50 50 CD cord-017772-zpf1xjqi 134 13 % % NN cord-017772-zpf1xjqi 134 14 5 5 CD cord-017772-zpf1xjqi 134 15 - - SYM cord-017772-zpf1xjqi 134 16 10 10 CD cord-017772-zpf1xjqi 134 17 days day NNS cord-017772-zpf1xjqi 134 18 after after IN cord-017772-zpf1xjqi 134 19 the the DT cord-017772-zpf1xjqi 134 20 initiation initiation NN cord-017772-zpf1xjqi 134 21 of of IN cord-017772-zpf1xjqi 134 22 heparin heparin NN cord-017772-zpf1xjqi 134 23 therapy therapy NN cord-017772-zpf1xjqi 134 24 [ [ -LRB- cord-017772-zpf1xjqi 134 25 55 55 CD cord-017772-zpf1xjqi 134 26 ] ] -RRB- cord-017772-zpf1xjqi 134 27 . . . cord-017772-zpf1xjqi 135 1 An an DT cord-017772-zpf1xjqi 135 2 important important JJ cord-017772-zpf1xjqi 135 3 caveat caveat NN cord-017772-zpf1xjqi 135 4 to to IN cord-017772-zpf1xjqi 135 5 this this DT cord-017772-zpf1xjqi 135 6 pattern pattern NN cord-017772-zpf1xjqi 135 7 is be VBZ cord-017772-zpf1xjqi 135 8 patients patient NNS cord-017772-zpf1xjqi 135 9 who who WP cord-017772-zpf1xjqi 135 10 have have VBP cord-017772-zpf1xjqi 135 11 been be VBN cord-017772-zpf1xjqi 135 12 previously previously RB cord-017772-zpf1xjqi 135 13 exposed expose VBN cord-017772-zpf1xjqi 135 14 to to IN cord-017772-zpf1xjqi 135 15 heparin heparin NN cord-017772-zpf1xjqi 135 16 . . . cord-017772-zpf1xjqi 136 1 Host host NN cord-017772-zpf1xjqi 136 2 IgG igg NN cord-017772-zpf1xjqi 136 3 against against IN cord-017772-zpf1xjqi 136 4 PF4heparin PF4heparin NNP cord-017772-zpf1xjqi 136 5 complexes complex NNS cord-017772-zpf1xjqi 136 6 can can MD cord-017772-zpf1xjqi 136 7 remain remain VB cord-017772-zpf1xjqi 136 8 active active JJ cord-017772-zpf1xjqi 136 9 for for IN cord-017772-zpf1xjqi 136 10 up up IN cord-017772-zpf1xjqi 136 11 to to TO cord-017772-zpf1xjqi 136 12 85 85 CD cord-017772-zpf1xjqi 136 13 days day NNS cord-017772-zpf1xjqi 136 14 . . . cord-017772-zpf1xjqi 137 1 During during IN cord-017772-zpf1xjqi 137 2 this this DT cord-017772-zpf1xjqi 137 3 window window NN cord-017772-zpf1xjqi 137 4 , , , cord-017772-zpf1xjqi 137 5 heparin heparin NN cord-017772-zpf1xjqi 137 6 re re NN cord-017772-zpf1xjqi 137 7 - - NN cord-017772-zpf1xjqi 137 8 exposure exposure NN cord-017772-zpf1xjqi 137 9 can can MD cord-017772-zpf1xjqi 137 10 produce produce VB cord-017772-zpf1xjqi 137 11 a a DT cord-017772-zpf1xjqi 137 12 rapid rapid JJ cord-017772-zpf1xjqi 137 13 drop drop NN cord-017772-zpf1xjqi 137 14 in in IN cord-017772-zpf1xjqi 137 15 platelet platelet NN cord-017772-zpf1xjqi 137 16 count count NN cord-017772-zpf1xjqi 137 17 within within IN cord-017772-zpf1xjqi 137 18 24 24 CD cord-017772-zpf1xjqi 137 19 hours hour NNS cord-017772-zpf1xjqi 137 20 [ [ -LRB- cord-017772-zpf1xjqi 137 21 52 52 CD cord-017772-zpf1xjqi 137 22 ] ] -RRB- cord-017772-zpf1xjqi 137 23 . . . cord-017772-zpf1xjqi 138 1 Up up IN cord-017772-zpf1xjqi 138 2 to to TO cord-017772-zpf1xjqi 138 3 30 30 CD cord-017772-zpf1xjqi 138 4 % % NN cord-017772-zpf1xjqi 138 5 of of IN cord-017772-zpf1xjqi 138 6 cases case NNS cord-017772-zpf1xjqi 138 7 of of IN cord-017772-zpf1xjqi 138 8 HIT HIT NNP cord-017772-zpf1xjqi 138 9 may may MD cord-017772-zpf1xjqi 138 10 present present VB cord-017772-zpf1xjqi 138 11 in in IN cord-017772-zpf1xjqi 138 12 this this DT cord-017772-zpf1xjqi 138 13 manner manner NN cord-017772-zpf1xjqi 138 14 [ [ -LRB- cord-017772-zpf1xjqi 138 15 55 55 CD cord-017772-zpf1xjqi 138 16 ] ] -RRB- cord-017772-zpf1xjqi 138 17 . . . cord-017772-zpf1xjqi 139 1 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 139 2 in in IN cord-017772-zpf1xjqi 139 3 HIT hit NN cord-017772-zpf1xjqi 139 4 is be VBZ cord-017772-zpf1xjqi 139 5 generally generally RB cord-017772-zpf1xjqi 139 6 less less RBR cord-017772-zpf1xjqi 139 7 severe severe JJ cord-017772-zpf1xjqi 139 8 than than IN cord-017772-zpf1xjqi 139 9 other other JJ cord-017772-zpf1xjqi 139 10 causes cause NNS cord-017772-zpf1xjqi 139 11 of of IN cord-017772-zpf1xjqi 139 12 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 139 13 in in IN cord-017772-zpf1xjqi 139 14 the the DT cord-017772-zpf1xjqi 139 15 ICU ICU NNP cord-017772-zpf1xjqi 139 16 with with IN cord-017772-zpf1xjqi 139 17 levels level NNS cord-017772-zpf1xjqi 139 18 rarely rarely RB cord-017772-zpf1xjqi 139 19 falling fall VBG cord-017772-zpf1xjqi 139 20 below below IN cord-017772-zpf1xjqi 139 21 20 20 CD cord-017772-zpf1xjqi 139 22 × × NN cord-017772-zpf1xjqi 139 23 10 10 CD cord-017772-zpf1xjqi 139 24 9 9 CD cord-017772-zpf1xjqi 139 25 cells cell NNS cord-017772-zpf1xjqi 139 26 / / SYM cord-017772-zpf1xjqi 139 27 L. L. NNP cord-017772-zpf1xjqi 140 1 [ [ -LRB- cord-017772-zpf1xjqi 140 2 54 54 CD cord-017772-zpf1xjqi 140 3 ] ] -RRB- cord-017772-zpf1xjqi 140 4 Up up IN cord-017772-zpf1xjqi 140 5 to to TO cord-017772-zpf1xjqi 140 6 20 20 CD cord-017772-zpf1xjqi 140 7 % % NN cord-017772-zpf1xjqi 140 8 of of IN cord-017772-zpf1xjqi 140 9 patients patient NNS cord-017772-zpf1xjqi 140 10 exposed expose VBN cord-017772-zpf1xjqi 140 11 to to IN cord-017772-zpf1xjqi 140 12 heparin heparin NN cord-017772-zpf1xjqi 140 13 produce produce NN cord-017772-zpf1xjqi 140 14 IgG igg NN cord-017772-zpf1xjqi 140 15 antibodies antibody NNS cord-017772-zpf1xjqi 140 16 against against IN cord-017772-zpf1xjqi 140 17 PF4-heparin pf4-heparin NN cord-017772-zpf1xjqi 140 18 complexes complex NNS cord-017772-zpf1xjqi 140 19 while while IN cord-017772-zpf1xjqi 140 20 only only RB cord-017772-zpf1xjqi 140 21 a a DT cord-017772-zpf1xjqi 140 22 small small JJ cord-017772-zpf1xjqi 140 23 minority minority NN cord-017772-zpf1xjqi 140 24 develop develop VB cord-017772-zpf1xjqi 140 25 HIT HIT VBN cord-017772-zpf1xjqi 140 26 [ [ -LRB- cord-017772-zpf1xjqi 140 27 56 56 CD cord-017772-zpf1xjqi 140 28 ] ] -RRB- cord-017772-zpf1xjqi 140 29 . . . cord-017772-zpf1xjqi 141 1 Given give VBN cord-017772-zpf1xjqi 141 2 the the DT cord-017772-zpf1xjqi 141 3 costs cost NNS cord-017772-zpf1xjqi 141 4 associated associate VBN cord-017772-zpf1xjqi 141 5 with with IN cord-017772-zpf1xjqi 141 6 laboratory laboratory NN cord-017772-zpf1xjqi 141 7 testing testing NN cord-017772-zpf1xjqi 141 8 for for IN cord-017772-zpf1xjqi 141 9 HIT hit NN cord-017772-zpf1xjqi 141 10 and and CC cord-017772-zpf1xjqi 141 11 the the DT cord-017772-zpf1xjqi 141 12 potential potential JJ cord-017772-zpf1xjqi 141 13 risk risk NN cord-017772-zpf1xjqi 141 14 of of IN cord-017772-zpf1xjqi 141 15 transitioning transition VBG cord-017772-zpf1xjqi 141 16 to to IN cord-017772-zpf1xjqi 141 17 a a DT cord-017772-zpf1xjqi 141 18 non non JJ cord-017772-zpf1xjqi 141 19 - - JJ cord-017772-zpf1xjqi 141 20 heparin heparin JJ cord-017772-zpf1xjqi 141 21 anticoagulant anticoagulant JJ cord-017772-zpf1xjqi 141 22 agent agent NN cord-017772-zpf1xjqi 141 23 , , , cord-017772-zpf1xjqi 141 24 the the DT cord-017772-zpf1xjqi 141 25 diagnosis diagnosis NN cord-017772-zpf1xjqi 141 26 of of IN cord-017772-zpf1xjqi 141 27 HIT HIT NNP cord-017772-zpf1xjqi 141 28 should should MD cord-017772-zpf1xjqi 141 29 only only RB cord-017772-zpf1xjqi 141 30 be be VB cord-017772-zpf1xjqi 141 31 pursued pursue VBN cord-017772-zpf1xjqi 141 32 in in IN cord-017772-zpf1xjqi 141 33 patients patient NNS cord-017772-zpf1xjqi 141 34 with with IN cord-017772-zpf1xjqi 141 35 an an DT cord-017772-zpf1xjqi 141 36 intermediate intermediate JJ cord-017772-zpf1xjqi 141 37 to to TO cord-017772-zpf1xjqi 141 38 high high JJ cord-017772-zpf1xjqi 141 39 pre pre JJ cord-017772-zpf1xjqi 141 40 - - JJ cord-017772-zpf1xjqi 141 41 test test JJ cord-017772-zpf1xjqi 141 42 probability probability NN cord-017772-zpf1xjqi 141 43 of of IN cord-017772-zpf1xjqi 141 44 having have VBG cord-017772-zpf1xjqi 141 45 the the DT cord-017772-zpf1xjqi 141 46 disease disease NN cord-017772-zpf1xjqi 141 47 [ [ -LRB- cord-017772-zpf1xjqi 141 48 57 57 CD cord-017772-zpf1xjqi 141 49 ] ] -RRB- cord-017772-zpf1xjqi 141 50 . . . cord-017772-zpf1xjqi 142 1 The the DT cord-017772-zpf1xjqi 142 2 most most RBS cord-017772-zpf1xjqi 142 3 widely widely RB cord-017772-zpf1xjqi 142 4 used use VBN cord-017772-zpf1xjqi 142 5 pre pre JJ cord-017772-zpf1xjqi 142 6 - - JJ cord-017772-zpf1xjqi 142 7 test test JJ cord-017772-zpf1xjqi 142 8 probability probability NN cord-017772-zpf1xjqi 142 9 assessment assessment NN cord-017772-zpf1xjqi 142 10 tool tool NN cord-017772-zpf1xjqi 142 11 for for IN cord-017772-zpf1xjqi 142 12 HIT HIT NNP cord-017772-zpf1xjqi 142 13 is be VBZ cord-017772-zpf1xjqi 142 14 the the DT cord-017772-zpf1xjqi 142 15 4Ts 4ts JJ cord-017772-zpf1xjqi 142 16 score score NN cord-017772-zpf1xjqi 142 17 ( ( -LRB- cord-017772-zpf1xjqi 142 18 Table Table NNP cord-017772-zpf1xjqi 142 19 83 83 CD cord-017772-zpf1xjqi 142 20 . . . cord-017772-zpf1xjqi 142 21 3 3 LS cord-017772-zpf1xjqi 142 22 ) ) -RRB- cord-017772-zpf1xjqi 142 23 [ [ -LRB- cord-017772-zpf1xjqi 142 24 58 58 CD cord-017772-zpf1xjqi 142 25 ] ] -RRB- cord-017772-zpf1xjqi 142 26 . . . cord-017772-zpf1xjqi 143 1 A a DT cord-017772-zpf1xjqi 143 2 score score NN cord-017772-zpf1xjqi 143 3 < < XX cord-017772-zpf1xjqi 143 4 4 4 CD cord-017772-zpf1xjqi 143 5 is be VBZ cord-017772-zpf1xjqi 143 6 associated associate VBN cord-017772-zpf1xjqi 143 7 with with IN cord-017772-zpf1xjqi 143 8 a a DT cord-017772-zpf1xjqi 143 9 negative negative JJ cord-017772-zpf1xjqi 143 10 predictive predictive JJ cord-017772-zpf1xjqi 143 11 value value NN cord-017772-zpf1xjqi 143 12 for for IN cord-017772-zpf1xjqi 143 13 HIT hit NN cord-017772-zpf1xjqi 143 14 of of IN cord-017772-zpf1xjqi 143 15 > > $ cord-017772-zpf1xjqi 143 16 99 99 CD cord-017772-zpf1xjqi 143 17 % % NN cord-017772-zpf1xjqi 143 18 and and CC cord-017772-zpf1xjqi 143 19 obviates obviate VBZ cord-017772-zpf1xjqi 143 20 the the DT cord-017772-zpf1xjqi 143 21 need need NN cord-017772-zpf1xjqi 143 22 for for IN cord-017772-zpf1xjqi 143 23 further further JJ cord-017772-zpf1xjqi 143 24 testing testing NN cord-017772-zpf1xjqi 143 25 [ [ -LRB- cord-017772-zpf1xjqi 143 26 59 59 CD cord-017772-zpf1xjqi 143 27 ] ] -RRB- cord-017772-zpf1xjqi 143 28 . . . cord-017772-zpf1xjqi 144 1 Patients patient NNS cord-017772-zpf1xjqi 144 2 with with IN cord-017772-zpf1xjqi 144 3 a a DT cord-017772-zpf1xjqi 144 4 score score NN cord-017772-zpf1xjqi 144 5 ≥ ≥ CD cord-017772-zpf1xjqi 144 6 4 4 CD cord-017772-zpf1xjqi 144 7 should should MD cord-017772-zpf1xjqi 144 8 undergo undergo VB cord-017772-zpf1xjqi 144 9 step step NN cord-017772-zpf1xjqi 144 10 - - HYPH cord-017772-zpf1xjqi 144 11 wise wise JJ cord-017772-zpf1xjqi 144 12 serologic serologic NN cord-017772-zpf1xjqi 144 13 testing testing NN cord-017772-zpf1xjqi 144 14 . . . cord-017772-zpf1xjqi 145 1 The the DT cord-017772-zpf1xjqi 145 2 initial initial JJ cord-017772-zpf1xjqi 145 3 serologic serologic JJ cord-017772-zpf1xjqi 145 4 test test NN cord-017772-zpf1xjqi 145 5 for for IN cord-017772-zpf1xjqi 145 6 patients patient NNS cord-017772-zpf1xjqi 145 7 with with IN cord-017772-zpf1xjqi 145 8 an an DT cord-017772-zpf1xjqi 145 9 intermediate intermediate JJ cord-017772-zpf1xjqi 145 10 to to TO cord-017772-zpf1xjqi 145 11 high high JJ cord-017772-zpf1xjqi 145 12 pre pre JJ cord-017772-zpf1xjqi 145 13 - - JJ cord-017772-zpf1xjqi 145 14 test test JJ cord-017772-zpf1xjqi 145 15 probability probability NN cord-017772-zpf1xjqi 145 16 of of IN cord-017772-zpf1xjqi 145 17 HIT hit NN cord-017772-zpf1xjqi 145 18 is be VBZ cord-017772-zpf1xjqi 145 19 an an DT cord-017772-zpf1xjqi 145 20 enzyme enzyme NN cord-017772-zpf1xjqi 145 21 - - HYPH cord-017772-zpf1xjqi 145 22 linked link VBN cord-017772-zpf1xjqi 145 23 immunoassay immunoassay NN cord-017772-zpf1xjqi 145 24 ( ( -LRB- cord-017772-zpf1xjqi 145 25 ELISA ELISA NNP cord-017772-zpf1xjqi 145 26 ) ) -RRB- cord-017772-zpf1xjqi 145 27 to to TO cord-017772-zpf1xjqi 145 28 detect detect VB cord-017772-zpf1xjqi 145 29 HIT HIT VBN cord-017772-zpf1xjqi 145 30 antibodies antibody NNS cord-017772-zpf1xjqi 145 31 . . . cord-017772-zpf1xjqi 146 1 These these DT cord-017772-zpf1xjqi 146 2 assays assay NNS cord-017772-zpf1xjqi 146 3 are be VBP cord-017772-zpf1xjqi 146 4 widely widely RB cord-017772-zpf1xjqi 146 5 available available JJ cord-017772-zpf1xjqi 146 6 and and CC cord-017772-zpf1xjqi 146 7 result result VB cord-017772-zpf1xjqi 146 8 in in IN cord-017772-zpf1xjqi 146 9 a a DT cord-017772-zpf1xjqi 146 10 matter matter NN cord-017772-zpf1xjqi 146 11 of of IN cord-017772-zpf1xjqi 146 12 hours hour NNS cord-017772-zpf1xjqi 146 13 . . . cord-017772-zpf1xjqi 147 1 IgG igg NN cord-017772-zpf1xjqi 147 2 - - HYPH cord-017772-zpf1xjqi 147 3 specific specific JJ cord-017772-zpf1xjqi 147 4 ELISAs elisa NNS cord-017772-zpf1xjqi 147 5 have have VBP cord-017772-zpf1xjqi 147 6 a a DT cord-017772-zpf1xjqi 147 7 sensitivity sensitivity NN cord-017772-zpf1xjqi 147 8 of of IN cord-017772-zpf1xjqi 147 9 96 96 CD cord-017772-zpf1xjqi 147 10 % % NN cord-017772-zpf1xjqi 147 11 and and CC cord-017772-zpf1xjqi 147 12 specificity specificity NN cord-017772-zpf1xjqi 147 13 of of IN cord-017772-zpf1xjqi 147 14 89 89 CD cord-017772-zpf1xjqi 147 15 % % NN cord-017772-zpf1xjqi 147 16 for for IN cord-017772-zpf1xjqi 147 17 the the DT cord-017772-zpf1xjqi 147 18 diagnosis diagnosis NN cord-017772-zpf1xjqi 147 19 of of IN cord-017772-zpf1xjqi 147 20 HIT hit VB cord-017772-zpf1xjqi 147 21 [ [ -LRB- cord-017772-zpf1xjqi 147 22 60 60 CD cord-017772-zpf1xjqi 147 23 ] ] -RRB- cord-017772-zpf1xjqi 147 24 . . . cord-017772-zpf1xjqi 148 1 Results result NNS cord-017772-zpf1xjqi 148 2 are be VBP cord-017772-zpf1xjqi 148 3 typically typically RB cord-017772-zpf1xjqi 148 4 reported report VBN cord-017772-zpf1xjqi 148 5 quantitatively quantitatively RB cord-017772-zpf1xjqi 148 6 as as IN cord-017772-zpf1xjqi 148 7 an an DT cord-017772-zpf1xjqi 148 8 optical optical JJ cord-017772-zpf1xjqi 148 9 density density NN cord-017772-zpf1xjqi 148 10 ( ( -LRB- cord-017772-zpf1xjqi 148 11 OD OD NNP cord-017772-zpf1xjqi 148 12 ) ) -RRB- cord-017772-zpf1xjqi 148 13 . . . cord-017772-zpf1xjqi 149 1 The the DT cord-017772-zpf1xjqi 149 2 higher high JJR cord-017772-zpf1xjqi 149 3 the the DT cord-017772-zpf1xjqi 149 4 OD OD NNP cord-017772-zpf1xjqi 149 5 threshold threshold NN cord-017772-zpf1xjqi 149 6 used use VBN cord-017772-zpf1xjqi 149 7 to to TO cord-017772-zpf1xjqi 149 8 identify identify VB cord-017772-zpf1xjqi 149 9 a a DT cord-017772-zpf1xjqi 149 10 positive positive JJ cord-017772-zpf1xjqi 149 11 test test NN cord-017772-zpf1xjqi 149 12 , , , cord-017772-zpf1xjqi 149 13 the the DT cord-017772-zpf1xjqi 149 14 more more RBR cord-017772-zpf1xjqi 149 15 likely likely RB cord-017772-zpf1xjqi 149 16 a a DT cord-017772-zpf1xjqi 149 17 positive positive JJ cord-017772-zpf1xjqi 149 18 ELISA ELISA NNP cord-017772-zpf1xjqi 149 19 will will MD cord-017772-zpf1xjqi 149 20 predict predict VB cord-017772-zpf1xjqi 149 21 a a DT cord-017772-zpf1xjqi 149 22 positive positive JJ cord-017772-zpf1xjqi 149 23 functional functional JJ cord-017772-zpf1xjqi 149 24 assay assay NN cord-017772-zpf1xjqi 149 25 . . . cord-017772-zpf1xjqi 150 1 The the DT cord-017772-zpf1xjqi 150 2 commonly commonly RB cord-017772-zpf1xjqi 150 3 used use VBN cord-017772-zpf1xjqi 150 4 OD OD NNP cord-017772-zpf1xjqi 150 5 cutoff cutoff NN cord-017772-zpf1xjqi 150 6 of of IN cord-017772-zpf1xjqi 150 7 0.4 0.4 CD cord-017772-zpf1xjqi 150 8 has have VBZ cord-017772-zpf1xjqi 150 9 a a DT cord-017772-zpf1xjqi 150 10 sensitivity sensitivity NN cord-017772-zpf1xjqi 150 11 of of IN cord-017772-zpf1xjqi 150 12 > > $ cord-017772-zpf1xjqi 150 13 99 99 CD cord-017772-zpf1xjqi 150 14 % % NN cord-017772-zpf1xjqi 150 15 for for IN cord-017772-zpf1xjqi 150 16 HIT hit NN cord-017772-zpf1xjqi 150 17 [ [ -LRB- cord-017772-zpf1xjqi 150 18 53 53 CD cord-017772-zpf1xjqi 150 19 ] ] -RRB- cord-017772-zpf1xjqi 150 20 . . . cord-017772-zpf1xjqi 151 1 Patients patient NNS cord-017772-zpf1xjqi 151 2 with with IN cord-017772-zpf1xjqi 151 3 a a DT cord-017772-zpf1xjqi 151 4 positive positive JJ cord-017772-zpf1xjqi 151 5 ELISA ELISA NNP cord-017772-zpf1xjqi 151 6 should should MD cord-017772-zpf1xjqi 151 7 undergo undergo VB cord-017772-zpf1xjqi 151 8 confirmatory confirmatory JJ cord-017772-zpf1xjqi 151 9 testing testing NN cord-017772-zpf1xjqi 151 10 with with IN cord-017772-zpf1xjqi 151 11 a a DT cord-017772-zpf1xjqi 151 12 functional functional JJ cord-017772-zpf1xjqi 151 13 assay assay NN cord-017772-zpf1xjqi 151 14 -typically -typically WDT cord-017772-zpf1xjqi 151 15 a a DT cord-017772-zpf1xjqi 151 16 serotonin serotonin NN cord-017772-zpf1xjqi 151 17 release release NN cord-017772-zpf1xjqi 151 18 assay assay NN cord-017772-zpf1xjqi 151 19 ( ( -LRB- cord-017772-zpf1xjqi 151 20 SRA SRA NNP cord-017772-zpf1xjqi 151 21 ) ) -RRB- cord-017772-zpf1xjqi 151 22 . . . cord-017772-zpf1xjqi 152 1 A a DT cord-017772-zpf1xjqi 152 2 SRA SRA NNP cord-017772-zpf1xjqi 152 3 evaluates evaluate VBZ cord-017772-zpf1xjqi 152 4 for for IN cord-017772-zpf1xjqi 152 5 in in FW cord-017772-zpf1xjqi 152 6 vitro vitro FW cord-017772-zpf1xjqi 152 7 activation activation NN cord-017772-zpf1xjqi 152 8 of of IN cord-017772-zpf1xjqi 152 9 platelets platelet NNS cord-017772-zpf1xjqi 152 10 in in IN cord-017772-zpf1xjqi 152 11 the the DT cord-017772-zpf1xjqi 152 12 presence presence NN cord-017772-zpf1xjqi 152 13 of of IN cord-017772-zpf1xjqi 152 14 patient patient JJ cord-017772-zpf1xjqi 152 15 serum serum NN cord-017772-zpf1xjqi 152 16 and and CC cord-017772-zpf1xjqi 152 17 heparin heparin NN cord-017772-zpf1xjqi 152 18 . . . cord-017772-zpf1xjqi 153 1 A a DT cord-017772-zpf1xjqi 153 2 positive positive JJ cord-017772-zpf1xjqi 153 3 SRA SRA NNP cord-017772-zpf1xjqi 153 4 has have VBZ cord-017772-zpf1xjqi 153 5 a a DT cord-017772-zpf1xjqi 153 6 specificity specificity NN cord-017772-zpf1xjqi 153 7 of of IN cord-017772-zpf1xjqi 153 8 nearly nearly RB cord-017772-zpf1xjqi 153 9 100 100 CD cord-017772-zpf1xjqi 153 10 % % NN cord-017772-zpf1xjqi 153 11 for for IN cord-017772-zpf1xjqi 153 12 the the DT cord-017772-zpf1xjqi 153 13 diagnosis diagnosis NN cord-017772-zpf1xjqi 153 14 of of IN cord-017772-zpf1xjqi 153 15 HIT hit VB cord-017772-zpf1xjqi 153 16 [ [ -LRB- cord-017772-zpf1xjqi 153 17 60 60 CD cord-017772-zpf1xjqi 153 18 ] ] -RRB- cord-017772-zpf1xjqi 153 19 . . . cord-017772-zpf1xjqi 154 1 The the DT cord-017772-zpf1xjqi 154 2 cornerstone cornerstone NN cord-017772-zpf1xjqi 154 3 of of IN cord-017772-zpf1xjqi 154 4 management management NN cord-017772-zpf1xjqi 154 5 for for IN cord-017772-zpf1xjqi 154 6 patients patient NNS cord-017772-zpf1xjqi 154 7 with with IN cord-017772-zpf1xjqi 154 8 either either CC cord-017772-zpf1xjqi 154 9 an an DT cord-017772-zpf1xjqi 154 10 intermediate intermediate JJ cord-017772-zpf1xjqi 154 11 to to TO cord-017772-zpf1xjqi 154 12 high high JJ cord-017772-zpf1xjqi 154 13 pre pre JJ cord-017772-zpf1xjqi 154 14 - - JJ cord-017772-zpf1xjqi 154 15 test test JJ cord-017772-zpf1xjqi 154 16 probability probability NN cord-017772-zpf1xjqi 154 17 of of IN cord-017772-zpf1xjqi 154 18 HIT hit NN cord-017772-zpf1xjqi 154 19 or or CC cord-017772-zpf1xjqi 154 20 a a DT cord-017772-zpf1xjqi 154 21 confirmed confirm VBN cord-017772-zpf1xjqi 154 22 diagnosis diagnosis NN cord-017772-zpf1xjqi 154 23 is be VBZ cord-017772-zpf1xjqi 154 24 transition transition NN cord-017772-zpf1xjqi 154 25 to to IN cord-017772-zpf1xjqi 154 26 a a DT cord-017772-zpf1xjqi 154 27 non non JJ cord-017772-zpf1xjqi 154 28 - - JJ cord-017772-zpf1xjqi 154 29 heparin heparin JJ cord-017772-zpf1xjqi 154 30 anticoagulant anticoagulant NN cord-017772-zpf1xjqi 154 31 . . . cord-017772-zpf1xjqi 155 1 Options option NNS cord-017772-zpf1xjqi 155 2 include include VBP cord-017772-zpf1xjqi 155 3 direct direct JJ cord-017772-zpf1xjqi 155 4 thrombin thrombin NN cord-017772-zpf1xjqi 155 5 inhibitors inhibitor NNS cord-017772-zpf1xjqi 155 6 ( ( -LRB- cord-017772-zpf1xjqi 155 7 e.g. e.g. RB cord-017772-zpf1xjqi 155 8 , , , cord-017772-zpf1xjqi 155 9 lepirudin lepirudin NNS cord-017772-zpf1xjqi 155 10 , , , cord-017772-zpf1xjqi 155 11 argatroban argatroban NNP cord-017772-zpf1xjqi 155 12 , , , cord-017772-zpf1xjqi 155 13 and and CC cord-017772-zpf1xjqi 155 14 bivalrudin bivalrudin NNP cord-017772-zpf1xjqi 155 15 ) ) -RRB- cord-017772-zpf1xjqi 155 16 and and CC cord-017772-zpf1xjqi 155 17 factor factor NN cord-017772-zpf1xjqi 155 18 Xa Xa NNP cord-017772-zpf1xjqi 155 19 inhibitors inhibitor NNS cord-017772-zpf1xjqi 155 20 ( ( -LRB- cord-017772-zpf1xjqi 155 21 e.g. e.g. RB cord-017772-zpf1xjqi 155 22 , , , cord-017772-zpf1xjqi 155 23 danaparoid danaparoid NN cord-017772-zpf1xjqi 155 24 and and CC cord-017772-zpf1xjqi 155 25 fondaparinux fondaparinux NNP cord-017772-zpf1xjqi 155 26 ) ) -RRB- cord-017772-zpf1xjqi 155 27 [ [ -LRB- cord-017772-zpf1xjqi 155 28 54 54 CD cord-017772-zpf1xjqi 155 29 ] ] -RRB- cord-017772-zpf1xjqi 155 30 . . . cord-017772-zpf1xjqi 156 1 There there EX cord-017772-zpf1xjqi 156 2 is be VBZ cord-017772-zpf1xjqi 156 3 currently currently RB cord-017772-zpf1xjqi 156 4 insufficient insufficient JJ cord-017772-zpf1xjqi 156 5 evidence evidence NN cord-017772-zpf1xjqi 156 6 to to TO cord-017772-zpf1xjqi 156 7 support support VB cord-017772-zpf1xjqi 156 8 the the DT cord-017772-zpf1xjqi 156 9 use use NN cord-017772-zpf1xjqi 156 10 of of IN cord-017772-zpf1xjqi 156 11 direct direct JJ cord-017772-zpf1xjqi 156 12 oral oral JJ cord-017772-zpf1xjqi 156 13 anticoagulant anticoagulant JJ cord-017772-zpf1xjqi 156 14 agents agent NNS cord-017772-zpf1xjqi 156 15 in in IN cord-017772-zpf1xjqi 156 16 this this DT cord-017772-zpf1xjqi 156 17 setting set VBG cord-017772-zpf1xjqi 156 18 [ [ -LRB- cord-017772-zpf1xjqi 156 19 53 53 CD cord-017772-zpf1xjqi 156 20 ] ] -RRB- cord-017772-zpf1xjqi 156 21 . . . cord-017772-zpf1xjqi 157 1 Warfarin Warfarin NNP cord-017772-zpf1xjqi 157 2 is be VBZ cord-017772-zpf1xjqi 157 3 contraindicated contraindicated JJ cord-017772-zpf1xjqi 157 4 in in IN cord-017772-zpf1xjqi 157 5 patients patient NNS cord-017772-zpf1xjqi 157 6 with with IN cord-017772-zpf1xjqi 157 7 HIT hit NN cord-017772-zpf1xjqi 157 8 until until IN cord-017772-zpf1xjqi 157 9 the the DT cord-017772-zpf1xjqi 157 10 platelet platelet NN cord-017772-zpf1xjqi 157 11 counts count VBZ cord-017772-zpf1xjqi 157 12 rises rise VBZ cord-017772-zpf1xjqi 157 13 above above IN cord-017772-zpf1xjqi 157 14 150 150 CD cord-017772-zpf1xjqi 157 15 x x SYM cord-017772-zpf1xjqi 157 16 10 10 CD cord-017772-zpf1xjqi 157 17 9 9 CD cord-017772-zpf1xjqi 157 18 cells cell NNS cord-017772-zpf1xjqi 157 19 / / SYM cord-017772-zpf1xjqi 157 20 L l NN cord-017772-zpf1xjqi 157 21 as as IN cord-017772-zpf1xjqi 157 22 warfarin warfarin NN cord-017772-zpf1xjqi 157 23 reduces reduce VBZ cord-017772-zpf1xjqi 157 24 protein protein NN cord-017772-zpf1xjqi 157 25 C c NN cord-017772-zpf1xjqi 157 26 levels level NNS cord-017772-zpf1xjqi 157 27 and and CC cord-017772-zpf1xjqi 157 28 may may MD cord-017772-zpf1xjqi 157 29 exacerbate exacerbate VB cord-017772-zpf1xjqi 157 30 thrombus thrombus NN cord-017772-zpf1xjqi 157 31 formation formation NN cord-017772-zpf1xjqi 157 32 [ [ -LRB- cord-017772-zpf1xjqi 157 33 54 54 CD cord-017772-zpf1xjqi 157 34 ] ] -RRB- cord-017772-zpf1xjqi 157 35 . . . cord-017772-zpf1xjqi 158 1 Platelet platelet NN cord-017772-zpf1xjqi 158 2 transfusions transfusion NNS cord-017772-zpf1xjqi 158 3 should should MD cord-017772-zpf1xjqi 158 4 be be VB cord-017772-zpf1xjqi 158 5 avoided avoid VBN cord-017772-zpf1xjqi 158 6 if if IN cord-017772-zpf1xjqi 158 7 possible possible JJ cord-017772-zpf1xjqi 158 8 and and CC cord-017772-zpf1xjqi 158 9 are be VBP cord-017772-zpf1xjqi 158 10 only only RB cord-017772-zpf1xjqi 158 11 recommended recommend VBN cord-017772-zpf1xjqi 158 12 for for IN cord-017772-zpf1xjqi 158 13 patients patient NNS cord-017772-zpf1xjqi 158 14 who who WP cord-017772-zpf1xjqi 158 15 are be VBP cord-017772-zpf1xjqi 158 16 actively actively RB cord-017772-zpf1xjqi 158 17 bleeding bleed VBG cord-017772-zpf1xjqi 158 18 or or CC cord-017772-zpf1xjqi 158 19 those those DT cord-017772-zpf1xjqi 158 20 undergoing undergo VBG cord-017772-zpf1xjqi 158 21 an an DT cord-017772-zpf1xjqi 158 22 invasive invasive JJ cord-017772-zpf1xjqi 158 23 procedure procedure NN cord-017772-zpf1xjqi 158 24 associated associate VBN cord-017772-zpf1xjqi 158 25 with with IN cord-017772-zpf1xjqi 158 26 a a DT cord-017772-zpf1xjqi 158 27 high high JJ cord-017772-zpf1xjqi 158 28 risk risk NN cord-017772-zpf1xjqi 158 29 of of IN cord-017772-zpf1xjqi 158 30 bleeding bleed VBG cord-017772-zpf1xjqi 158 31 [ [ -LRB- cord-017772-zpf1xjqi 158 32 54 54 CD cord-017772-zpf1xjqi 158 33 ] ] -RRB- cord-017772-zpf1xjqi 158 34 . . . cord-017772-zpf1xjqi 159 1 Sepsis sepsis NN cord-017772-zpf1xjqi 159 2 is be VBZ cord-017772-zpf1xjqi 159 3 one one CD cord-017772-zpf1xjqi 159 4 of of IN cord-017772-zpf1xjqi 159 5 the the DT cord-017772-zpf1xjqi 159 6 most most RBS cord-017772-zpf1xjqi 159 7 common common JJ cord-017772-zpf1xjqi 159 8 causes cause NNS cord-017772-zpf1xjqi 159 9 of of IN cord-017772-zpf1xjqi 159 10 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 159 11 in in IN cord-017772-zpf1xjqi 159 12 the the DT cord-017772-zpf1xjqi 159 13 ICU ICU NNP cord-017772-zpf1xjqi 159 14 and and CC cord-017772-zpf1xjqi 159 15 may may MD cord-017772-zpf1xjqi 159 16 contribute contribute VB cord-017772-zpf1xjqi 159 17 to to IN cord-017772-zpf1xjqi 159 18 a a DT cord-017772-zpf1xjqi 159 19 low low JJ cord-017772-zpf1xjqi 159 20 platelet platelet NN cord-017772-zpf1xjqi 159 21 count count NN cord-017772-zpf1xjqi 159 22 in in IN cord-017772-zpf1xjqi 159 23 up up IN cord-017772-zpf1xjqi 159 24 to to TO cord-017772-zpf1xjqi 159 25 75 75 CD cord-017772-zpf1xjqi 159 26 % % NN cord-017772-zpf1xjqi 159 27 of of IN cord-017772-zpf1xjqi 159 28 casas casa NNS cord-017772-zpf1xjqi 159 29 [ [ -LRB- cord-017772-zpf1xjqi 159 30 17 17 CD cord-017772-zpf1xjqi 159 31 ] ] -RRB- cord-017772-zpf1xjqi 159 32 . . . cord-017772-zpf1xjqi 160 1 The the DT cord-017772-zpf1xjqi 160 2 incidence incidence NN cord-017772-zpf1xjqi 160 3 of of IN cord-017772-zpf1xjqi 160 4 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 160 5 in in IN cord-017772-zpf1xjqi 160 6 patients patient NNS cord-017772-zpf1xjqi 160 7 with with IN cord-017772-zpf1xjqi 160 8 sepsis sepsis NN cord-017772-zpf1xjqi 160 9 varies vary VBZ cord-017772-zpf1xjqi 160 10 by by IN cord-017772-zpf1xjqi 160 11 illness illness NN cord-017772-zpf1xjqi 160 12 severity severity NN cord-017772-zpf1xjqi 160 13 . . . cord-017772-zpf1xjqi 161 1 In in IN cord-017772-zpf1xjqi 161 2 a a DT cord-017772-zpf1xjqi 161 3 multicenter multicenter JJ cord-017772-zpf1xjqi 161 4 prospective prospective JJ cord-017772-zpf1xjqi 161 5 evaluation evaluation NN cord-017772-zpf1xjqi 161 6 of of IN cord-017772-zpf1xjqi 161 7 1238 1238 CD cord-017772-zpf1xjqi 161 8 patients patient NNS cord-017772-zpf1xjqi 161 9 with with IN cord-017772-zpf1xjqi 161 10 severe severe JJ cord-017772-zpf1xjqi 161 11 sepsis sepsis NN cord-017772-zpf1xjqi 161 12 , , , cord-017772-zpf1xjqi 161 13 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 161 14 was be VBD cord-017772-zpf1xjqi 161 15 present present JJ cord-017772-zpf1xjqi 161 16 in in IN cord-017772-zpf1xjqi 161 17 14.5 14.5 CD cord-017772-zpf1xjqi 161 18 % % NN cord-017772-zpf1xjqi 161 19 of of IN cord-017772-zpf1xjqi 161 20 patients patient NNS cord-017772-zpf1xjqi 161 21 [ [ -LRB- cord-017772-zpf1xjqi 161 22 61 61 CD cord-017772-zpf1xjqi 161 23 ] ] -RRB- cord-017772-zpf1xjqi 161 24 . . . cord-017772-zpf1xjqi 162 1 In in IN cord-017772-zpf1xjqi 162 2 patients patient NNS cord-017772-zpf1xjqi 162 3 with with IN cord-017772-zpf1xjqi 162 4 septic septic JJ cord-017772-zpf1xjqi 162 5 shock shock NN cord-017772-zpf1xjqi 162 6 , , , cord-017772-zpf1xjqi 162 7 the the DT cord-017772-zpf1xjqi 162 8 incidence incidence NN cord-017772-zpf1xjqi 162 9 of of IN cord-017772-zpf1xjqi 162 10 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 162 11 approaches approach VBZ cord-017772-zpf1xjqi 162 12 50 50 CD cord-017772-zpf1xjqi 162 13 % % NN cord-017772-zpf1xjqi 162 14 [ [ -LRB- cord-017772-zpf1xjqi 162 15 62 62 CD cord-017772-zpf1xjqi 162 16 , , , cord-017772-zpf1xjqi 162 17 63 63 CD cord-017772-zpf1xjqi 162 18 ] ] -RRB- cord-017772-zpf1xjqi 162 19 . . . cord-017772-zpf1xjqi 163 1 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 163 2 has have VBZ cord-017772-zpf1xjqi 163 3 consistently consistently RB cord-017772-zpf1xjqi 163 4 been be VBN cord-017772-zpf1xjqi 163 5 associated associate VBN cord-017772-zpf1xjqi 163 6 with with IN cord-017772-zpf1xjqi 163 7 increased increase VBN cord-017772-zpf1xjqi 163 8 mortality mortality NN cord-017772-zpf1xjqi 163 9 in in IN cord-017772-zpf1xjqi 163 10 septic septic JJ cord-017772-zpf1xjqi 163 11 patients patient NNS cord-017772-zpf1xjqi 163 12 [ [ -LRB- cord-017772-zpf1xjqi 163 13 10 10 CD cord-017772-zpf1xjqi 163 14 , , , cord-017772-zpf1xjqi 163 15 61 61 CD cord-017772-zpf1xjqi 163 16 , , , cord-017772-zpf1xjqi 163 17 62 62 CD cord-017772-zpf1xjqi 163 18 ] ] -RRB- cord-017772-zpf1xjqi 163 19 . . . cord-017772-zpf1xjqi 164 1 Multiple multiple JJ cord-017772-zpf1xjqi 164 2 mechanisms mechanism NNS cord-017772-zpf1xjqi 164 3 cause cause VBP cord-017772-zpf1xjqi 164 4 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 164 5 during during IN cord-017772-zpf1xjqi 164 6 sepsis sepsis NN cord-017772-zpf1xjqi 164 7 . . . cord-017772-zpf1xjqi 165 1 Decreased decrease VBN cord-017772-zpf1xjqi 165 2 bone bone NN cord-017772-zpf1xjqi 165 3 marrow marrow NN cord-017772-zpf1xjqi 165 4 production production NN cord-017772-zpf1xjqi 165 5 , , , cord-017772-zpf1xjqi 165 6 hemophagocytosis hemophagocytosis NN cord-017772-zpf1xjqi 165 7 , , , cord-017772-zpf1xjqi 165 8 platelet platelet NN cord-017772-zpf1xjqi 165 9 consumption consumption NN cord-017772-zpf1xjqi 165 10 in in IN cord-017772-zpf1xjqi 165 11 microvascular microvascular JJ cord-017772-zpf1xjqi 165 12 beds bed NNS cord-017772-zpf1xjqi 165 13 , , , cord-017772-zpf1xjqi 165 14 sequestration sequestration NN cord-017772-zpf1xjqi 165 15 , , , cord-017772-zpf1xjqi 165 16 and and CC cord-017772-zpf1xjqi 165 17 hemodilution hemodilution NN cord-017772-zpf1xjqi 165 18 may may MD cord-017772-zpf1xjqi 165 19 all all RB cord-017772-zpf1xjqi 165 20 contribute contribute VB cord-017772-zpf1xjqi 165 21 to to IN cord-017772-zpf1xjqi 165 22 varying vary VBG cord-017772-zpf1xjqi 165 23 degrees degree NNS cord-017772-zpf1xjqi 165 24 [ [ -LRB- cord-017772-zpf1xjqi 165 25 64 64 CD cord-017772-zpf1xjqi 165 26 ] ] -RRB- cord-017772-zpf1xjqi 165 27 . . . cord-017772-zpf1xjqi 166 1 Septic septic JJ cord-017772-zpf1xjqi 166 2 patients patient NNS cord-017772-zpf1xjqi 166 3 are be VBP cord-017772-zpf1xjqi 166 4 at at IN cord-017772-zpf1xjqi 166 5 high high JJ cord-017772-zpf1xjqi 166 6 risk risk NN cord-017772-zpf1xjqi 166 7 for for IN cord-017772-zpf1xjqi 166 8 DIC DIC NNP cord-017772-zpf1xjqi 166 9 which which WDT cord-017772-zpf1xjqi 166 10 can can MD cord-017772-zpf1xjqi 166 11 further further RB cord-017772-zpf1xjqi 166 12 lower low JJR cord-017772-zpf1xjqi 166 13 platelet platelet NN cord-017772-zpf1xjqi 166 14 counts count NNS cord-017772-zpf1xjqi 166 15 . . . cord-017772-zpf1xjqi 167 1 Additionally additionally RB cord-017772-zpf1xjqi 167 2 , , , cord-017772-zpf1xjqi 167 3 many many JJ cord-017772-zpf1xjqi 167 4 medications medication NNS cord-017772-zpf1xjqi 167 5 routinely routinely RB cord-017772-zpf1xjqi 167 6 administered administer VBN cord-017772-zpf1xjqi 167 7 to to TO cord-017772-zpf1xjqi 167 8 septic septic JJ cord-017772-zpf1xjqi 167 9 patients patient NNS cord-017772-zpf1xjqi 167 10 including include VBG cord-017772-zpf1xjqi 167 11 antibiotics antibiotic NNS cord-017772-zpf1xjqi 167 12 are be VBP cord-017772-zpf1xjqi 167 13 associated associate VBN cord-017772-zpf1xjqi 167 14 with with IN cord-017772-zpf1xjqi 167 15 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 167 16 . . . cord-017772-zpf1xjqi 168 1 Based base VBN cord-017772-zpf1xjqi 168 2 on on IN cord-017772-zpf1xjqi 168 3 very very RB cord-017772-zpf1xjqi 168 4 low low JJ cord-017772-zpf1xjqi 168 5 - - HYPH cord-017772-zpf1xjqi 168 6 quality quality NN cord-017772-zpf1xjqi 168 7 evidence evidence NN cord-017772-zpf1xjqi 168 8 , , , cord-017772-zpf1xjqi 168 9 the the DT cord-017772-zpf1xjqi 168 10 Surviving Surviving NNP cord-017772-zpf1xjqi 168 11 Sepsis Sepsis NNP cord-017772-zpf1xjqi 168 12 Campaign Campaign NNP cord-017772-zpf1xjqi 168 13 recommends recommend VBZ cord-017772-zpf1xjqi 168 14 prophylactic prophylactic JJ cord-017772-zpf1xjqi 168 15 platelet platelet NN cord-017772-zpf1xjqi 168 16 transfusions transfusion NNS cord-017772-zpf1xjqi 168 17 in in IN cord-017772-zpf1xjqi 168 18 septic septic JJ cord-017772-zpf1xjqi 168 19 patients patient NNS cord-017772-zpf1xjqi 168 20 with with IN cord-017772-zpf1xjqi 168 21 a a DT cord-017772-zpf1xjqi 168 22 platelet platelet NN cord-017772-zpf1xjqi 168 23 count count NN cord-017772-zpf1xjqi 168 24 < < XX cord-017772-zpf1xjqi 168 25 10 10 CD cord-017772-zpf1xjqi 168 26 × × NN cord-017772-zpf1xjqi 168 27 10 10 CD cord-017772-zpf1xjqi 168 28 9 9 CD cord-017772-zpf1xjqi 168 29 cells cell NNS cord-017772-zpf1xjqi 168 30 / / SYM cord-017772-zpf1xjqi 168 31 L l NN cord-017772-zpf1xjqi 168 32 and and CC cord-017772-zpf1xjqi 168 33 20 20 CD cord-017772-zpf1xjqi 168 34 × × NN cord-017772-zpf1xjqi 168 35 10 10 CD cord-017772-zpf1xjqi 168 36 9 9 CD cord-017772-zpf1xjqi 168 37 cells cell NNS cord-017772-zpf1xjqi 168 38 / / SYM cord-017772-zpf1xjqi 168 39 L l NN cord-017772-zpf1xjqi 168 40 for for IN cord-017772-zpf1xjqi 168 41 patients patient NNS cord-017772-zpf1xjqi 168 42 at at IN cord-017772-zpf1xjqi 168 43 high high JJ cord-017772-zpf1xjqi 168 44 risk risk NN cord-017772-zpf1xjqi 168 45 of of IN cord-017772-zpf1xjqi 168 46 bleeding bleed VBG cord-017772-zpf1xjqi 168 47 . . . cord-017772-zpf1xjqi 169 1 A a DT cord-017772-zpf1xjqi 169 2 platelet platelet NN cord-017772-zpf1xjqi 169 3 count count NN cord-017772-zpf1xjqi 169 4 > > XX cord-017772-zpf1xjqi 170 1 50 50 CD cord-017772-zpf1xjqi 170 2 × × NN cord-017772-zpf1xjqi 170 3 10 10 CD cord-017772-zpf1xjqi 170 4 9 9 CD cord-017772-zpf1xjqi 170 5 cells/ cells/ CD cord-017772-zpf1xjqi 171 1 L L NNP cord-017772-zpf1xjqi 171 2 is be VBZ cord-017772-zpf1xjqi 171 3 recommended recommend VBN cord-017772-zpf1xjqi 171 4 for for IN cord-017772-zpf1xjqi 171 5 patients patient NNS cord-017772-zpf1xjqi 171 6 who who WP cord-017772-zpf1xjqi 171 7 are be VBP cord-017772-zpf1xjqi 171 8 actively actively RB cord-017772-zpf1xjqi 171 9 bleeding bleed VBG cord-017772-zpf1xjqi 171 10 or or CC cord-017772-zpf1xjqi 171 11 undergoing undergo VBG cord-017772-zpf1xjqi 171 12 invasive invasive JJ cord-017772-zpf1xjqi 171 13 procedures procedure NNS cord-017772-zpf1xjqi 171 14 [ [ -LRB- cord-017772-zpf1xjqi 171 15 65 65 CD cord-017772-zpf1xjqi 171 16 ] ] -RRB- cord-017772-zpf1xjqi 171 17 . . . cord-017772-zpf1xjqi 172 1 Dilutional dilutional JJ cord-017772-zpf1xjqi 172 2 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 172 3 is be VBZ cord-017772-zpf1xjqi 172 4 a a DT cord-017772-zpf1xjqi 172 5 well well RB cord-017772-zpf1xjqi 172 6 - - HYPH cord-017772-zpf1xjqi 172 7 recognized recognize VBN cord-017772-zpf1xjqi 172 8 complication complication NN cord-017772-zpf1xjqi 172 9 of of IN cord-017772-zpf1xjqi 172 10 massive massive JJ cord-017772-zpf1xjqi 172 11 transfusion transfusion NN cord-017772-zpf1xjqi 172 12 . . . cord-017772-zpf1xjqi 173 1 The the DT cord-017772-zpf1xjqi 173 2 incidence incidence NN cord-017772-zpf1xjqi 173 3 of of IN cord-017772-zpf1xjqi 173 4 severe severe JJ cord-017772-zpf1xjqi 173 5 thrombocytopenia thrombocytopenia NNS cord-017772-zpf1xjqi 173 6 ( ( -LRB- cord-017772-zpf1xjqi 173 7 defined define VBN cord-017772-zpf1xjqi 173 8 as as IN cord-017772-zpf1xjqi 173 9 a a DT cord-017772-zpf1xjqi 173 10 platelet platelet NN cord-017772-zpf1xjqi 173 11 count count NN cord-017772-zpf1xjqi 173 12 < < XX cord-017772-zpf1xjqi 173 13 50 50 CD cord-017772-zpf1xjqi 173 14 × × NN cord-017772-zpf1xjqi 173 15 10 10 CD cord-017772-zpf1xjqi 173 16 9 9 CD cord-017772-zpf1xjqi 173 17 cells cell NNS cord-017772-zpf1xjqi 173 18 / / SYM cord-017772-zpf1xjqi 173 19 L l NN cord-017772-zpf1xjqi 173 20 ) ) -RRB- cord-017772-zpf1xjqi 173 21 may may MD cord-017772-zpf1xjqi 173 22 be be VB cord-017772-zpf1xjqi 173 23 as as RB cord-017772-zpf1xjqi 173 24 high high JJ cord-017772-zpf1xjqi 173 25 as as IN cord-017772-zpf1xjqi 173 26 75 75 CD cord-017772-zpf1xjqi 173 27 % % NN cord-017772-zpf1xjqi 173 28 when when WRB cord-017772-zpf1xjqi 173 29 patients patient NNS cord-017772-zpf1xjqi 173 30 require require VBP cord-017772-zpf1xjqi 173 31 more more JJR cord-017772-zpf1xjqi 173 32 than than IN cord-017772-zpf1xjqi 173 33 20 20 CD cord-017772-zpf1xjqi 173 34 red red JJ cord-017772-zpf1xjqi 173 35 blood blood NN cord-017772-zpf1xjqi 173 36 cell cell NN cord-017772-zpf1xjqi 173 37 containing contain VBG cord-017772-zpf1xjqi 173 38 products product NNS cord-017772-zpf1xjqi 173 39 [ [ -LRB- cord-017772-zpf1xjqi 173 40 66 66 CD cord-017772-zpf1xjqi 173 41 ] ] -RRB- cord-017772-zpf1xjqi 173 42 . . . cord-017772-zpf1xjqi 174 1 Prompt prompt JJ cord-017772-zpf1xjqi 174 2 damage damage NN cord-017772-zpf1xjqi 174 3 control control NN cord-017772-zpf1xjqi 174 4 and and CC cord-017772-zpf1xjqi 174 5 transfusion transfusion NN cord-017772-zpf1xjqi 174 6 of of IN cord-017772-zpf1xjqi 174 7 blood blood NN cord-017772-zpf1xjqi 174 8 products product NNS cord-017772-zpf1xjqi 174 9 in in IN cord-017772-zpf1xjqi 174 10 a a DT cord-017772-zpf1xjqi 174 11 balanced balanced JJ cord-017772-zpf1xjqi 174 12 ratio ratio NN cord-017772-zpf1xjqi 174 13 ( ( -LRB- cord-017772-zpf1xjqi 174 14 1:1:1 1:1:1 CD cord-017772-zpf1xjqi 174 15 of of IN cord-017772-zpf1xjqi 174 16 red red JJ cord-017772-zpf1xjqi 174 17 blood blood NN cord-017772-zpf1xjqi 174 18 cells cell NNS cord-017772-zpf1xjqi 174 19 : : : cord-017772-zpf1xjqi 174 20 plasma plasma NN cord-017772-zpf1xjqi 174 21 : : : cord-017772-zpf1xjqi 174 22 platelets platelet NNS cord-017772-zpf1xjqi 174 23 ) ) -RRB- cord-017772-zpf1xjqi 174 24 are be VBP cord-017772-zpf1xjqi 174 25 important important JJ cord-017772-zpf1xjqi 174 26 preventative preventative JJ cord-017772-zpf1xjqi 174 27 strategies strategy NNS cord-017772-zpf1xjqi 174 28 [ [ -LRB- cord-017772-zpf1xjqi 174 29 67 67 CD cord-017772-zpf1xjqi 174 30 ] ] -RRB- cord-017772-zpf1xjqi 174 31 . . . cord-017772-zpf1xjqi 175 1 Step step NN cord-017772-zpf1xjqi 175 2 7 7 CD cord-017772-zpf1xjqi 175 3 : : : cord-017772-zpf1xjqi 175 4 Evaluate evaluate VB cord-017772-zpf1xjqi 175 5 Support Support NNP cord-017772-zpf1xjqi 175 6 Devices Devices NNPS cord-017772-zpf1xjqi 175 7 Support Support NNP cord-017772-zpf1xjqi 175 8 devices device NNS cord-017772-zpf1xjqi 175 9 used use VBN cord-017772-zpf1xjqi 175 10 in in IN cord-017772-zpf1xjqi 175 11 critically critically RB cord-017772-zpf1xjqi 175 12 ill ill JJ cord-017772-zpf1xjqi 175 13 patients patient NNS cord-017772-zpf1xjqi 175 14 may may MD cord-017772-zpf1xjqi 175 15 lower lower VB cord-017772-zpf1xjqi 175 16 platelet platelet NN cord-017772-zpf1xjqi 175 17 counts count NNS cord-017772-zpf1xjqi 175 18 through through IN cord-017772-zpf1xjqi 175 19 mechanical mechanical JJ cord-017772-zpf1xjqi 175 20 shearing shearing NN cord-017772-zpf1xjqi 175 21 . . . cord-017772-zpf1xjqi 176 1 Veno Veno NNP cord-017772-zpf1xjqi 176 2 - - HYPH cord-017772-zpf1xjqi 176 3 venous venous JJ cord-017772-zpf1xjqi 176 4 extracorporeal extracorporeal JJ cord-017772-zpf1xjqi 176 5 membrane membrane NN cord-017772-zpf1xjqi 176 6 oxygenation oxygenation NN cord-017772-zpf1xjqi 176 7 ( ( -LRB- cord-017772-zpf1xjqi 176 8 VV VV NNP cord-017772-zpf1xjqi 176 9 - - HYPH cord-017772-zpf1xjqi 176 10 ECMO ECMO NNP cord-017772-zpf1xjqi 176 11 ) ) -RRB- cord-017772-zpf1xjqi 176 12 is be VBZ cord-017772-zpf1xjqi 176 13 increasingly increasingly RB cord-017772-zpf1xjqi 176 14 utilized utilize VBN cord-017772-zpf1xjqi 176 15 in in IN cord-017772-zpf1xjqi 176 16 the the DT cord-017772-zpf1xjqi 176 17 management management NN cord-017772-zpf1xjqi 176 18 of of IN cord-017772-zpf1xjqi 176 19 severe severe JJ cord-017772-zpf1xjqi 176 20 acute acute JJ cord-017772-zpf1xjqi 176 21 respiratory respiratory JJ cord-017772-zpf1xjqi 176 22 distress distress NN cord-017772-zpf1xjqi 176 23 syndrome syndrome NN cord-017772-zpf1xjqi 176 24 ( ( -LRB- cord-017772-zpf1xjqi 176 25 ARDS ARDS NNP cord-017772-zpf1xjqi 176 26 ) ) -RRB- cord-017772-zpf1xjqi 176 27 . . . cord-017772-zpf1xjqi 177 1 In in IN cord-017772-zpf1xjqi 177 2 a a DT cord-017772-zpf1xjqi 177 3 retrospective retrospective JJ cord-017772-zpf1xjqi 177 4 study study NN cord-017772-zpf1xjqi 177 5 of of IN cord-017772-zpf1xjqi 177 6 100 100 CD cord-017772-zpf1xjqi 177 7 patients patient NNS cord-017772-zpf1xjqi 177 8 placed place VBN cord-017772-zpf1xjqi 177 9 on on IN cord-017772-zpf1xjqi 177 10 VV VV NNP cord-017772-zpf1xjqi 177 11 - - HYPH cord-017772-zpf1xjqi 177 12 ECMO ECMO NNP cord-017772-zpf1xjqi 177 13 for for IN cord-017772-zpf1xjqi 177 14 respiratory respiratory JJ cord-017772-zpf1xjqi 177 15 failure failure NN cord-017772-zpf1xjqi 177 16 , , , cord-017772-zpf1xjqi 177 17 22 22 CD cord-017772-zpf1xjqi 177 18 % % NN cord-017772-zpf1xjqi 177 19 developed develop VBN cord-017772-zpf1xjqi 177 20 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 177 21 [ [ -LRB- cord-017772-zpf1xjqi 177 22 68 68 CD cord-017772-zpf1xjqi 177 23 ] ] -RRB- cord-017772-zpf1xjqi 177 24 . . . cord-017772-zpf1xjqi 178 1 Severity severity NN cord-017772-zpf1xjqi 178 2 of of IN cord-017772-zpf1xjqi 178 3 illness illness NN cord-017772-zpf1xjqi 178 4 and and CC cord-017772-zpf1xjqi 178 5 the the DT cord-017772-zpf1xjqi 178 6 platelet platelet NN cord-017772-zpf1xjqi 178 7 count count NN cord-017772-zpf1xjqi 178 8 at at IN cord-017772-zpf1xjqi 178 9 the the DT cord-017772-zpf1xjqi 178 10 time time NN cord-017772-zpf1xjqi 178 11 of of IN cord-017772-zpf1xjqi 178 12 cannulation cannulation NN cord-017772-zpf1xjqi 178 13 were be VBD cord-017772-zpf1xjqi 178 14 the the DT cord-017772-zpf1xjqi 178 15 strongest strong JJS cord-017772-zpf1xjqi 178 16 predictors predictor NNS cord-017772-zpf1xjqi 178 17 of of IN cord-017772-zpf1xjqi 178 18 developing develop VBG cord-017772-zpf1xjqi 178 19 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 178 20 . . . cord-017772-zpf1xjqi 179 1 In in IN cord-017772-zpf1xjqi 179 2 a a DT cord-017772-zpf1xjqi 179 3 large large JJ cord-017772-zpf1xjqi 179 4 randomized randomized JJ cord-017772-zpf1xjqi 179 5 trial trial NN cord-017772-zpf1xjqi 179 6 of of IN cord-017772-zpf1xjqi 179 7 ECMO ECMO NNP cord-017772-zpf1xjqi 179 8 for for IN cord-017772-zpf1xjqi 179 9 severe severe JJ cord-017772-zpf1xjqi 179 10 ARDS ARDS NNP cord-017772-zpf1xjqi 179 11 , , , cord-017772-zpf1xjqi 179 12 27 27 CD cord-017772-zpf1xjqi 179 13 % % NN cord-017772-zpf1xjqi 179 14 of of IN cord-017772-zpf1xjqi 179 15 patients patient NNS cord-017772-zpf1xjqi 179 16 randomized randomize VBN cord-017772-zpf1xjqi 179 17 to to IN cord-017772-zpf1xjqi 179 18 ECMO ECMO NNP cord-017772-zpf1xjqi 179 19 developed develop VBN cord-017772-zpf1xjqi 179 20 Adapted adapt VBN cord-017772-zpf1xjqi 179 21 from from IN cord-017772-zpf1xjqi 179 22 Lo Lo NNP cord-017772-zpf1xjqi 179 23 [ [ -LRB- cord-017772-zpf1xjqi 179 24 58 58 CD cord-017772-zpf1xjqi 179 25 ] ] -RRB- cord-017772-zpf1xjqi 179 26 . . . cord-017772-zpf1xjqi 180 1 A a DT cord-017772-zpf1xjqi 180 2 score score NN cord-017772-zpf1xjqi 180 3 ≤ ≤ NN cord-017772-zpf1xjqi 180 4 3 3 CD cord-017772-zpf1xjqi 180 5 suggests suggest VBZ cord-017772-zpf1xjqi 180 6 a a DT cord-017772-zpf1xjqi 180 7 low low JJ cord-017772-zpf1xjqi 180 8 pre pre JJ cord-017772-zpf1xjqi 180 9 - - JJ cord-017772-zpf1xjqi 180 10 test test JJ cord-017772-zpf1xjqi 180 11 probability probability NN cord-017772-zpf1xjqi 180 12 for for IN cord-017772-zpf1xjqi 180 13 HIT hit NN cord-017772-zpf1xjqi 180 14 , , , cord-017772-zpf1xjqi 180 15 a a DT cord-017772-zpf1xjqi 180 16 score score NN cord-017772-zpf1xjqi 180 17 4 4 CD cord-017772-zpf1xjqi 180 18 - - SYM cord-017772-zpf1xjqi 180 19 5 5 CD cord-017772-zpf1xjqi 180 20 an an DT cord-017772-zpf1xjqi 180 21 intermediate intermediate JJ cord-017772-zpf1xjqi 180 22 probability probability NN cord-017772-zpf1xjqi 180 23 , , , cord-017772-zpf1xjqi 180 24 and and CC cord-017772-zpf1xjqi 180 25 a a DT cord-017772-zpf1xjqi 180 26 score score NN cord-017772-zpf1xjqi 180 27 > > XX cord-017772-zpf1xjqi 180 28 5 5 CD cord-017772-zpf1xjqi 180 29 a a DT cord-017772-zpf1xjqi 180 30 high high JJ cord-017772-zpf1xjqi 180 31 probability probability NN cord-017772-zpf1xjqi 180 32 severe severe JJ cord-017772-zpf1xjqi 180 33 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 180 34 ( ( -LRB- cord-017772-zpf1xjqi 180 35 defined define VBN cord-017772-zpf1xjqi 180 36 as as IN cord-017772-zpf1xjqi 180 37 a a DT cord-017772-zpf1xjqi 180 38 platelet platelet NN cord-017772-zpf1xjqi 180 39 count count NN cord-017772-zpf1xjqi 180 40 < < XX cord-017772-zpf1xjqi 180 41 20 20 CD cord-017772-zpf1xjqi 180 42 × × NN cord-017772-zpf1xjqi 180 43 10 10 CD cord-017772-zpf1xjqi 180 44 9 9 CD cord-017772-zpf1xjqi 180 45 cells cell NNS cord-017772-zpf1xjqi 180 46 / / SYM cord-017772-zpf1xjqi 180 47 L L NNP cord-017772-zpf1xjqi 180 48 ) ) -RRB- cord-017772-zpf1xjqi 180 49 vs vs IN cord-017772-zpf1xjqi 180 50 16 16 CD cord-017772-zpf1xjqi 180 51 % % NN cord-017772-zpf1xjqi 180 52 in in IN cord-017772-zpf1xjqi 180 53 the the DT cord-017772-zpf1xjqi 180 54 control control NN cord-017772-zpf1xjqi 180 55 arm arm NN cord-017772-zpf1xjqi 180 56 [ [ -LRB- cord-017772-zpf1xjqi 180 57 69 69 CD cord-017772-zpf1xjqi 180 58 ] ] -RRB- cord-017772-zpf1xjqi 180 59 . . . cord-017772-zpf1xjqi 181 1 For for IN cord-017772-zpf1xjqi 181 2 patients patient NNS cord-017772-zpf1xjqi 181 3 placed place VBN cord-017772-zpf1xjqi 181 4 on on IN cord-017772-zpf1xjqi 181 5 an an DT cord-017772-zpf1xjqi 181 6 intra intra JJ cord-017772-zpf1xjqi 181 7 - - JJ cord-017772-zpf1xjqi 181 8 aortic aortic JJ cord-017772-zpf1xjqi 181 9 balloon balloon NN cord-017772-zpf1xjqi 181 10 pump pump NN cord-017772-zpf1xjqi 181 11 , , , cord-017772-zpf1xjqi 181 12 roughly roughly RB cord-017772-zpf1xjqi 181 13 50 50 CD cord-017772-zpf1xjqi 181 14 % % NN cord-017772-zpf1xjqi 181 15 will will MD cord-017772-zpf1xjqi 181 16 develop develop VB cord-017772-zpf1xjqi 181 17 thrombocytopenia thrombocytopenia JJ cord-017772-zpf1xjqi 181 18 [ [ -LRB- cord-017772-zpf1xjqi 181 19 70 70 CD cord-017772-zpf1xjqi 181 20 , , , cord-017772-zpf1xjqi 181 21 71 71 CD cord-017772-zpf1xjqi 181 22 ] ] -RRB- cord-017772-zpf1xjqi 181 23 . . . cord-017772-zpf1xjqi 182 1 Despite despite IN cord-017772-zpf1xjqi 182 2 the the DT cord-017772-zpf1xjqi 182 3 high high JJ cord-017772-zpf1xjqi 182 4 incidence incidence NN cord-017772-zpf1xjqi 182 5 of of IN cord-017772-zpf1xjqi 182 6 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 182 7 in in IN cord-017772-zpf1xjqi 182 8 critically critically RB cord-017772-zpf1xjqi 182 9 ill ill JJ cord-017772-zpf1xjqi 182 10 patients patient NNS cord-017772-zpf1xjqi 182 11 , , , cord-017772-zpf1xjqi 182 12 there there EX cord-017772-zpf1xjqi 182 13 is be VBZ cord-017772-zpf1xjqi 182 14 a a DT cord-017772-zpf1xjqi 182 15 paucity paucity NN cord-017772-zpf1xjqi 182 16 of of IN cord-017772-zpf1xjqi 182 17 data datum NNS cord-017772-zpf1xjqi 182 18 to to TO cord-017772-zpf1xjqi 182 19 guide guide VB cord-017772-zpf1xjqi 182 20 when when WRB cord-017772-zpf1xjqi 182 21 prophylactic prophylactic JJ cord-017772-zpf1xjqi 182 22 platelet platelet NN cord-017772-zpf1xjqi 182 23 transfusion transfusion NN cord-017772-zpf1xjqi 182 24 is be VBZ cord-017772-zpf1xjqi 182 25 indicated indicate VBN cord-017772-zpf1xjqi 182 26 . . . cord-017772-zpf1xjqi 183 1 Indeed indeed RB cord-017772-zpf1xjqi 183 2 , , , cord-017772-zpf1xjqi 183 3 a a DT cord-017772-zpf1xjqi 183 4 recent recent JJ cord-017772-zpf1xjqi 183 5 systematic systematic JJ cord-017772-zpf1xjqi 183 6 review review NN cord-017772-zpf1xjqi 183 7 did do VBD cord-017772-zpf1xjqi 183 8 not not RB cord-017772-zpf1xjqi 183 9 identify identify VB cord-017772-zpf1xjqi 183 10 a a DT cord-017772-zpf1xjqi 183 11 single single JJ cord-017772-zpf1xjqi 183 12 high high JJ cord-017772-zpf1xjqi 183 13 - - HYPH cord-017772-zpf1xjqi 183 14 quality quality NN cord-017772-zpf1xjqi 183 15 study study NN cord-017772-zpf1xjqi 183 16 that that WDT cord-017772-zpf1xjqi 183 17 investigated investigate VBD cord-017772-zpf1xjqi 183 18 the the DT cord-017772-zpf1xjqi 183 19 impact impact NN cord-017772-zpf1xjqi 183 20 of of IN cord-017772-zpf1xjqi 183 21 prophylactic prophylactic JJ cord-017772-zpf1xjqi 183 22 platelet platelet NN cord-017772-zpf1xjqi 183 23 transfusions transfusion NNS cord-017772-zpf1xjqi 183 24 on on IN cord-017772-zpf1xjqi 183 25 bleeding bleed VBG cord-017772-zpf1xjqi 183 26 rates rate NNS cord-017772-zpf1xjqi 183 27 in in IN cord-017772-zpf1xjqi 183 28 critically critically RB cord-017772-zpf1xjqi 183 29 ill ill JJ cord-017772-zpf1xjqi 183 30 patients patient NNS cord-017772-zpf1xjqi 183 31 [ [ -LRB- cord-017772-zpf1xjqi 183 32 72 72 CD cord-017772-zpf1xjqi 183 33 ] ] -RRB- cord-017772-zpf1xjqi 183 34 . . . cord-017772-zpf1xjqi 184 1 Recommendations recommendation NNS cord-017772-zpf1xjqi 184 2 on on IN cord-017772-zpf1xjqi 184 3 prophylactic prophylactic JJ cord-017772-zpf1xjqi 184 4 platelet platelet NN cord-017772-zpf1xjqi 184 5 transfusions transfusion NNS cord-017772-zpf1xjqi 184 6 in in IN cord-017772-zpf1xjqi 184 7 critically critically RB cord-017772-zpf1xjqi 184 8 ill ill JJ cord-017772-zpf1xjqi 184 9 patients patient NNS cord-017772-zpf1xjqi 184 10 are be VBP cord-017772-zpf1xjqi 184 11 largely largely RB cord-017772-zpf1xjqi 184 12 extrapolated extrapolate VBN cord-017772-zpf1xjqi 184 13 from from IN cord-017772-zpf1xjqi 184 14 studies study NNS cord-017772-zpf1xjqi 184 15 in in IN cord-017772-zpf1xjqi 184 16 patients patient NNS cord-017772-zpf1xjqi 184 17 with with IN cord-017772-zpf1xjqi 184 18 hematologic hematologic JJ cord-017772-zpf1xjqi 184 19 malignancies malignancy NNS cord-017772-zpf1xjqi 184 20 . . . cord-017772-zpf1xjqi 185 1 In in IN cord-017772-zpf1xjqi 185 2 a a DT cord-017772-zpf1xjqi 185 3 landmark landmark JJ cord-017772-zpf1xjqi 185 4 trial trial NN cord-017772-zpf1xjqi 185 5 of of IN cord-017772-zpf1xjqi 185 6 platelet platelet NN cord-017772-zpf1xjqi 185 7 transfusion transfusion NN cord-017772-zpf1xjqi 185 8 thresholds threshold NNS cord-017772-zpf1xjqi 185 9 in in IN cord-017772-zpf1xjqi 185 10 255 255 CD cord-017772-zpf1xjqi 185 11 patients patient NNS cord-017772-zpf1xjqi 185 12 with with IN cord-017772-zpf1xjqi 185 13 acute acute JJ cord-017772-zpf1xjqi 185 14 myeloid myeloid NN cord-017772-zpf1xjqi 185 15 leukemia leukemia NN cord-017772-zpf1xjqi 185 16 undergoing undergo VBG cord-017772-zpf1xjqi 185 17 induction induction NN cord-017772-zpf1xjqi 185 18 chemotherapy chemotherapy NN cord-017772-zpf1xjqi 185 19 , , , cord-017772-zpf1xjqi 185 20 a a DT cord-017772-zpf1xjqi 185 21 transfusion transfusion NN cord-017772-zpf1xjqi 185 22 threshold threshold NN cord-017772-zpf1xjqi 185 23 of of IN cord-017772-zpf1xjqi 185 24 10 10 CD cord-017772-zpf1xjqi 185 25 × × NN cord-017772-zpf1xjqi 185 26 10 10 CD cord-017772-zpf1xjqi 185 27 9 9 CD cord-017772-zpf1xjqi 185 28 cells cell NNS cord-017772-zpf1xjqi 185 29 / / SYM cord-017772-zpf1xjqi 185 30 L L NNP cord-017772-zpf1xjqi 185 31 did do VBD cord-017772-zpf1xjqi 185 32 not not RB cord-017772-zpf1xjqi 185 33 increase increase VB cord-017772-zpf1xjqi 185 34 the the DT cord-017772-zpf1xjqi 185 35 risk risk NN cord-017772-zpf1xjqi 185 36 of of IN cord-017772-zpf1xjqi 185 37 major major JJ cord-017772-zpf1xjqi 185 38 bleeding bleeding NN cord-017772-zpf1xjqi 185 39 and and CC cord-017772-zpf1xjqi 185 40 reduced reduce VBD cord-017772-zpf1xjqi 185 41 the the DT cord-017772-zpf1xjqi 185 42 need need NN cord-017772-zpf1xjqi 185 43 for for IN cord-017772-zpf1xjqi 185 44 platelet platelet NN cord-017772-zpf1xjqi 185 45 transfusions transfusion NNS cord-017772-zpf1xjqi 185 46 by by IN cord-017772-zpf1xjqi 185 47 21.5 21.5 CD cord-017772-zpf1xjqi 185 48 % % NN cord-017772-zpf1xjqi 185 49 compared compare VBN cord-017772-zpf1xjqi 185 50 to to IN cord-017772-zpf1xjqi 185 51 a a DT cord-017772-zpf1xjqi 185 52 threshold threshold NN cord-017772-zpf1xjqi 185 53 of of IN cord-017772-zpf1xjqi 185 54 20 20 CD cord-017772-zpf1xjqi 185 55 × × NN cord-017772-zpf1xjqi 185 56 10 10 CD cord-017772-zpf1xjqi 185 57 9 9 CD cord-017772-zpf1xjqi 185 58 cells cell NNS cord-017772-zpf1xjqi 185 59 / / SYM cord-017772-zpf1xjqi 185 60 L. L. NNP cord-017772-zpf1xjqi 185 61 [ [ -LRB- cord-017772-zpf1xjqi 185 62 73 73 CD cord-017772-zpf1xjqi 185 63 ] ] -RRB- cord-017772-zpf1xjqi 186 1 A a DT cord-017772-zpf1xjqi 186 2 recent recent JJ cord-017772-zpf1xjqi 186 3 Cochrane Cochrane NNP cord-017772-zpf1xjqi 186 4 review review NN cord-017772-zpf1xjqi 186 5 supports support VBZ cord-017772-zpf1xjqi 186 6 the the DT cord-017772-zpf1xjqi 186 7 conclusion conclusion NN cord-017772-zpf1xjqi 186 8 that that IN cord-017772-zpf1xjqi 186 9 a a DT cord-017772-zpf1xjqi 186 10 restrictive restrictive JJ cord-017772-zpf1xjqi 186 11 platelet platelet NN cord-017772-zpf1xjqi 186 12 transfusion transfusion NN cord-017772-zpf1xjqi 186 13 threshold threshold NN cord-017772-zpf1xjqi 186 14 is be VBZ cord-017772-zpf1xjqi 186 15 safe safe JJ cord-017772-zpf1xjqi 186 16 in in IN cord-017772-zpf1xjqi 186 17 patients patient NNS cord-017772-zpf1xjqi 186 18 with with IN cord-017772-zpf1xjqi 186 19 hematologic hematologic JJ cord-017772-zpf1xjqi 186 20 malignancies malignancy NNS cord-017772-zpf1xjqi 186 21 [ [ -LRB- cord-017772-zpf1xjqi 186 22 74 74 CD cord-017772-zpf1xjqi 186 23 ] ] -RRB- cord-017772-zpf1xjqi 186 24 . . . cord-017772-zpf1xjqi 187 1 Guidelines guideline NNS cord-017772-zpf1xjqi 187 2 by by IN cord-017772-zpf1xjqi 187 3 the the DT cord-017772-zpf1xjqi 187 4 American American NNP cord-017772-zpf1xjqi 187 5 Society Society NNP cord-017772-zpf1xjqi 187 6 of of IN cord-017772-zpf1xjqi 187 7 Clinical Clinical NNP cord-017772-zpf1xjqi 187 8 Oncology Oncology NNP cord-017772-zpf1xjqi 187 9 recommend recommend VBP cord-017772-zpf1xjqi 187 10 a a DT cord-017772-zpf1xjqi 187 11 prophylactic prophylactic JJ cord-017772-zpf1xjqi 187 12 platelet platelet NN cord-017772-zpf1xjqi 187 13 transfusion transfusion NN cord-017772-zpf1xjqi 187 14 threshold threshold NN cord-017772-zpf1xjqi 187 15 of of IN cord-017772-zpf1xjqi 187 16 10 10 CD cord-017772-zpf1xjqi 187 17 × × NN cord-017772-zpf1xjqi 187 18 10 10 CD cord-017772-zpf1xjqi 187 19 9 9 CD cord-017772-zpf1xjqi 187 20 cells cell NNS cord-017772-zpf1xjqi 187 21 / / SYM cord-017772-zpf1xjqi 187 22 L l NN cord-017772-zpf1xjqi 187 23 in in IN cord-017772-zpf1xjqi 187 24 patients patient NNS cord-017772-zpf1xjqi 187 25 with with IN cord-017772-zpf1xjqi 187 26 malignancy malignancy NN cord-017772-zpf1xjqi 187 27 [ [ -LRB- cord-017772-zpf1xjqi 187 28 75 75 CD cord-017772-zpf1xjqi 187 29 ] ] -RRB- cord-017772-zpf1xjqi 187 30 . . . cord-017772-zpf1xjqi 188 1 It -PRON- PRP cord-017772-zpf1xjqi 188 2 is be VBZ cord-017772-zpf1xjqi 188 3 unclear unclear JJ cord-017772-zpf1xjqi 188 4 , , , cord-017772-zpf1xjqi 188 5 however however RB cord-017772-zpf1xjqi 188 6 , , , cord-017772-zpf1xjqi 188 7 if if IN cord-017772-zpf1xjqi 188 8 data datum NNS cord-017772-zpf1xjqi 188 9 from from IN cord-017772-zpf1xjqi 188 10 patients patient NNS cord-017772-zpf1xjqi 188 11 with with IN cord-017772-zpf1xjqi 188 12 malignancies malignancy NNS cord-017772-zpf1xjqi 188 13 can can MD cord-017772-zpf1xjqi 188 14 be be VB cord-017772-zpf1xjqi 188 15 reliably reliably RB cord-017772-zpf1xjqi 188 16 generalized generalize VBN cord-017772-zpf1xjqi 188 17 to to IN cord-017772-zpf1xjqi 188 18 the the DT cord-017772-zpf1xjqi 188 19 heterogeneous heterogeneous JJ cord-017772-zpf1xjqi 188 20 group group NN cord-017772-zpf1xjqi 188 21 of of IN cord-017772-zpf1xjqi 188 22 patients patient NNS cord-017772-zpf1xjqi 188 23 cared care VBN cord-017772-zpf1xjqi 188 24 for for IN cord-017772-zpf1xjqi 188 25 in in IN cord-017772-zpf1xjqi 188 26 the the DT cord-017772-zpf1xjqi 188 27 ICU ICU NNP cord-017772-zpf1xjqi 188 28 [ [ -LRB- cord-017772-zpf1xjqi 188 29 76 76 CD cord-017772-zpf1xjqi 188 30 ] ] -RRB- cord-017772-zpf1xjqi 188 31 . . . cord-017772-zpf1xjqi 189 1 Some some DT cord-017772-zpf1xjqi 189 2 have have VBP cord-017772-zpf1xjqi 189 3 advocated advocate VBN cord-017772-zpf1xjqi 189 4 for for IN cord-017772-zpf1xjqi 189 5 an an DT cord-017772-zpf1xjqi 189 6 approach approach NN cord-017772-zpf1xjqi 189 7 which which WDT cord-017772-zpf1xjqi 189 8 reserves reserve VBZ cord-017772-zpf1xjqi 189 9 platelet platelet NN cord-017772-zpf1xjqi 189 10 transfusions transfusion NNS cord-017772-zpf1xjqi 189 11 for for IN cord-017772-zpf1xjqi 189 12 critically critically RB cord-017772-zpf1xjqi 189 13 ill ill JJ cord-017772-zpf1xjqi 189 14 patients patient NNS cord-017772-zpf1xjqi 189 15 with with IN cord-017772-zpf1xjqi 189 16 clinical clinical JJ cord-017772-zpf1xjqi 189 17 evidence evidence NN cord-017772-zpf1xjqi 189 18 of of IN cord-017772-zpf1xjqi 189 19 bleeding bleed VBG cord-017772-zpf1xjqi 189 20 ( ( -LRB- cord-017772-zpf1xjqi 189 21 regardless regardless RB cord-017772-zpf1xjqi 189 22 of of IN cord-017772-zpf1xjqi 189 23 the the DT cord-017772-zpf1xjqi 189 24 actual actual JJ cord-017772-zpf1xjqi 189 25 platelet platelet NN cord-017772-zpf1xjqi 189 26 count count NN cord-017772-zpf1xjqi 189 27 ) ) -RRB- cord-017772-zpf1xjqi 190 1 [ [ -LRB- cord-017772-zpf1xjqi 190 2 48 48 CD cord-017772-zpf1xjqi 190 3 ] ] -RRB- cord-017772-zpf1xjqi 190 4 . . . cord-017772-zpf1xjqi 191 1 However however RB cord-017772-zpf1xjqi 191 2 , , , cord-017772-zpf1xjqi 191 3 there there EX cord-017772-zpf1xjqi 191 4 is be VBZ cord-017772-zpf1xjqi 191 5 insufficient insufficient JJ cord-017772-zpf1xjqi 191 6 data datum NNS cord-017772-zpf1xjqi 191 7 to to TO cord-017772-zpf1xjqi 191 8 support support VB cord-017772-zpf1xjqi 191 9 the the DT cord-017772-zpf1xjqi 191 10 safety safety NN cord-017772-zpf1xjqi 191 11 or or CC cord-017772-zpf1xjqi 191 12 efficacy efficacy NN cord-017772-zpf1xjqi 191 13 of of IN cord-017772-zpf1xjqi 191 14 this this DT cord-017772-zpf1xjqi 191 15 practice practice NN cord-017772-zpf1xjqi 191 16 . . . cord-017772-zpf1xjqi 192 1 There there EX cord-017772-zpf1xjqi 192 2 is be VBZ cord-017772-zpf1xjqi 192 3 equally equally RB cord-017772-zpf1xjqi 192 4 limited limited JJ cord-017772-zpf1xjqi 192 5 evidence evidence NN cord-017772-zpf1xjqi 192 6 to to TO cord-017772-zpf1xjqi 192 7 guide guide VB cord-017772-zpf1xjqi 192 8 the the DT cord-017772-zpf1xjqi 192 9 platelet platelet NN cord-017772-zpf1xjqi 192 10 count count NN cord-017772-zpf1xjqi 192 11 needed need VBN cord-017772-zpf1xjqi 192 12 to to TO cord-017772-zpf1xjqi 192 13 limit limit VB cord-017772-zpf1xjqi 192 14 bleeding bleed VBG cord-017772-zpf1xjqi 192 15 complications complication NNS cord-017772-zpf1xjqi 192 16 during during IN cord-017772-zpf1xjqi 192 17 bedside bedside NN cord-017772-zpf1xjqi 192 18 procedures procedure NNS cord-017772-zpf1xjqi 192 19 commonly commonly RB cord-017772-zpf1xjqi 192 20 performed perform VBN cord-017772-zpf1xjqi 192 21 in in IN cord-017772-zpf1xjqi 192 22 the the DT cord-017772-zpf1xjqi 192 23 ICU ICU NNP cord-017772-zpf1xjqi 192 24 . . . cord-017772-zpf1xjqi 193 1 The the DT cord-017772-zpf1xjqi 193 2 American American NNP cord-017772-zpf1xjqi 193 3 Association Association NNP cord-017772-zpf1xjqi 193 4 of of IN cord-017772-zpf1xjqi 193 5 Blood Blood NNP cord-017772-zpf1xjqi 193 6 Banks Banks NNPS cord-017772-zpf1xjqi 193 7 recommends recommend VBZ cord-017772-zpf1xjqi 193 8 a a DT cord-017772-zpf1xjqi 193 9 platelet platelet NN cord-017772-zpf1xjqi 193 10 threshold threshold NN cord-017772-zpf1xjqi 193 11 of of IN cord-017772-zpf1xjqi 193 12 20 20 CD cord-017772-zpf1xjqi 193 13 × × NN cord-017772-zpf1xjqi 193 14 10 10 CD cord-017772-zpf1xjqi 193 15 9 9 CD cord-017772-zpf1xjqi 193 16 cells cell NNS cord-017772-zpf1xjqi 193 17 / / SYM cord-017772-zpf1xjqi 193 18 L l NN cord-017772-zpf1xjqi 193 19 for for IN cord-017772-zpf1xjqi 193 20 patients patient NNS cord-017772-zpf1xjqi 193 21 undergoing undergo VBG cord-017772-zpf1xjqi 193 22 central central JJ cord-017772-zpf1xjqi 193 23 line line NN cord-017772-zpf1xjqi 193 24 insertion insertion NN cord-017772-zpf1xjqi 193 25 and and CC cord-017772-zpf1xjqi 193 26 50 50 CD cord-017772-zpf1xjqi 193 27 × × NN cord-017772-zpf1xjqi 193 28 10 10 CD cord-017772-zpf1xjqi 193 29 9 9 CD cord-017772-zpf1xjqi 193 30 cells cell NNS cord-017772-zpf1xjqi 193 31 / / SYM cord-017772-zpf1xjqi 193 32 L l NN cord-017772-zpf1xjqi 193 33 for for IN cord-017772-zpf1xjqi 193 34 patients patient NNS cord-017772-zpf1xjqi 193 35 undergoing undergo VBG cord-017772-zpf1xjqi 193 36 lumbar lumbar JJ cord-017772-zpf1xjqi 193 37 puncture puncture NN cord-017772-zpf1xjqi 193 38 although although IN cord-017772-zpf1xjqi 193 39 both both DT cord-017772-zpf1xjqi 193 40 are be VBP cord-017772-zpf1xjqi 193 41 weak weak JJ cord-017772-zpf1xjqi 193 42 recommendations recommendation NNS cord-017772-zpf1xjqi 193 43 supported support VBN cord-017772-zpf1xjqi 193 44 by by IN cord-017772-zpf1xjqi 193 45 low low JJ cord-017772-zpf1xjqi 193 46 - - HYPH cord-017772-zpf1xjqi 193 47 quality quality NN cord-017772-zpf1xjqi 193 48 evidence evidence NN cord-017772-zpf1xjqi 193 49 [ [ -LRB- cord-017772-zpf1xjqi 193 50 77 77 CD cord-017772-zpf1xjqi 193 51 ] ] -RRB- cord-017772-zpf1xjqi 193 52 . . . cord-017772-zpf1xjqi 194 1 A a DT cord-017772-zpf1xjqi 194 2 recent recent JJ cord-017772-zpf1xjqi 194 3 Cochrane Cochrane NNP cord-017772-zpf1xjqi 194 4 review review NN cord-017772-zpf1xjqi 194 5 of of IN cord-017772-zpf1xjqi 194 6 platelet platelet NN cord-017772-zpf1xjqi 194 7 thresholds threshold NNS cord-017772-zpf1xjqi 194 8 for for IN cord-017772-zpf1xjqi 194 9 patients patient NNS cord-017772-zpf1xjqi 194 10 undergoing undergo VBG cord-017772-zpf1xjqi 194 11 central central JJ cord-017772-zpf1xjqi 194 12 line line NN cord-017772-zpf1xjqi 194 13 insertion insertion NN cord-017772-zpf1xjqi 194 14 was be VBD cord-017772-zpf1xjqi 194 15 unable unable JJ cord-017772-zpf1xjqi 194 16 to to TO cord-017772-zpf1xjqi 194 17 draw draw VB cord-017772-zpf1xjqi 194 18 any any DT cord-017772-zpf1xjqi 194 19 conclusions conclusion NNS cord-017772-zpf1xjqi 194 20 given give VBN cord-017772-zpf1xjqi 194 21 the the DT cord-017772-zpf1xjqi 194 22 complete complete JJ cord-017772-zpf1xjqi 194 23 lack lack NN cord-017772-zpf1xjqi 194 24 of of IN cord-017772-zpf1xjqi 194 25 data datum NNS cord-017772-zpf1xjqi 194 26 on on IN cord-017772-zpf1xjqi 194 27 the the DT cord-017772-zpf1xjqi 194 28 subject subject NN cord-017772-zpf1xjqi 194 29 [ [ -LRB- cord-017772-zpf1xjqi 194 30 78 78 CD cord-017772-zpf1xjqi 194 31 ] ] -RRB- cord-017772-zpf1xjqi 194 32 . . . cord-017772-zpf1xjqi 195 1 There there EX cord-017772-zpf1xjqi 195 2 is be VBZ cord-017772-zpf1xjqi 195 3 mounting mount VBG cord-017772-zpf1xjqi 195 4 evidence evidence NN cord-017772-zpf1xjqi 195 5 that that IN cord-017772-zpf1xjqi 195 6 thoracentesis thoracentesis NN cord-017772-zpf1xjqi 195 7 can can MD cord-017772-zpf1xjqi 195 8 be be VB cord-017772-zpf1xjqi 195 9 safely safely RB cord-017772-zpf1xjqi 195 10 performed perform VBN cord-017772-zpf1xjqi 195 11 by by IN cord-017772-zpf1xjqi 195 12 an an DT cord-017772-zpf1xjqi 195 13 experienced experienced JJ cord-017772-zpf1xjqi 195 14 operator operator NN cord-017772-zpf1xjqi 195 15 in in IN cord-017772-zpf1xjqi 195 16 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 195 17 patients patient NNS cord-017772-zpf1xjqi 195 18 without without IN cord-017772-zpf1xjqi 195 19 prophylactic prophylactic JJ cord-017772-zpf1xjqi 195 20 platelet platelet NN cord-017772-zpf1xjqi 195 21 transfusions transfusion NNS cord-017772-zpf1xjqi 195 22 [ [ -LRB- cord-017772-zpf1xjqi 195 23 79 79 CD cord-017772-zpf1xjqi 195 24 ] ] -RRB- cord-017772-zpf1xjqi 195 25 . . . cord-017772-zpf1xjqi 196 1 Platelet platelet NN cord-017772-zpf1xjqi 196 2 biology biology NN cord-017772-zpf1xjqi 196 3 and and CC cord-017772-zpf1xjqi 196 4 functions function NNS cord-017772-zpf1xjqi 196 5 : : : cord-017772-zpf1xjqi 196 6 new new JJ cord-017772-zpf1xjqi 196 7 concepts concept NNS cord-017772-zpf1xjqi 196 8 and and CC cord-017772-zpf1xjqi 196 9 clinical clinical JJ cord-017772-zpf1xjqi 196 10 perspectives perspective NNS cord-017772-zpf1xjqi 197 1 Beyond beyond IN cord-017772-zpf1xjqi 197 2 thrombosis thrombosis NN cord-017772-zpf1xjqi 197 3 : : : cord-017772-zpf1xjqi 197 4 the the DT cord-017772-zpf1xjqi 197 5 versatile versatile JJ cord-017772-zpf1xjqi 197 6 platelet platelet NN cord-017772-zpf1xjqi 197 7 in in IN cord-017772-zpf1xjqi 197 8 critical critical JJ cord-017772-zpf1xjqi 197 9 illness illness NN cord-017772-zpf1xjqi 197 10 Platelets platelet NNS cord-017772-zpf1xjqi 197 11 and and CC cord-017772-zpf1xjqi 197 12 the the DT cord-017772-zpf1xjqi 197 13 immune immune JJ cord-017772-zpf1xjqi 197 14 continuum continuum NN cord-017772-zpf1xjqi 197 15 Coagulopathy Coagulopathy NNP cord-017772-zpf1xjqi 197 16 in in IN cord-017772-zpf1xjqi 197 17 critically critically RB cord-017772-zpf1xjqi 197 18 ill ill JJ cord-017772-zpf1xjqi 197 19 patients patient NNS cord-017772-zpf1xjqi 197 20 : : : cord-017772-zpf1xjqi 197 21 part part NN cord-017772-zpf1xjqi 197 22 1 1 CD cord-017772-zpf1xjqi 197 23 : : : cord-017772-zpf1xjqi 197 24 platelet platelet NN cord-017772-zpf1xjqi 197 25 disorders disorder NNS cord-017772-zpf1xjqi 197 26 Thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 197 27 disorders disorder NNS cord-017772-zpf1xjqi 197 28 in in IN cord-017772-zpf1xjqi 197 29 critically critically RB cord-017772-zpf1xjqi 197 30 ill ill JJ cord-017772-zpf1xjqi 197 31 patients patient NNS cord-017772-zpf1xjqi 198 1 Time time NN cord-017772-zpf1xjqi 198 2 course course NN cord-017772-zpf1xjqi 198 3 of of IN cord-017772-zpf1xjqi 198 4 platelet platelet NN cord-017772-zpf1xjqi 198 5 counts count NNS cord-017772-zpf1xjqi 198 6 in in IN cord-017772-zpf1xjqi 198 7 critically critically RB cord-017772-zpf1xjqi 198 8 ill ill JJ cord-017772-zpf1xjqi 198 9 patients patient NNS cord-017772-zpf1xjqi 198 10 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 198 11 in in IN cord-017772-zpf1xjqi 198 12 medical medical JJ cord-017772-zpf1xjqi 198 13 - - HYPH cord-017772-zpf1xjqi 198 14 surgical surgical JJ cord-017772-zpf1xjqi 198 15 critically critically RB cord-017772-zpf1xjqi 198 16 ill ill JJ cord-017772-zpf1xjqi 198 17 patients patient NNS cord-017772-zpf1xjqi 198 18 : : : cord-017772-zpf1xjqi 199 1 prevalence prevalence NN cord-017772-zpf1xjqi 199 2 , , , cord-017772-zpf1xjqi 199 3 incidence incidence NN cord-017772-zpf1xjqi 199 4 , , , cord-017772-zpf1xjqi 199 5 and and CC cord-017772-zpf1xjqi 199 6 risk risk NN cord-017772-zpf1xjqi 199 7 factors factor NNS cord-017772-zpf1xjqi 199 8 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 199 9 in in IN cord-017772-zpf1xjqi 199 10 critically critically RB cord-017772-zpf1xjqi 199 11 ill ill JJ cord-017772-zpf1xjqi 199 12 patients patient NNS cord-017772-zpf1xjqi 199 13 receiving receive VBG cord-017772-zpf1xjqi 199 14 thromboprophylaxis thromboprophylaxis NN cord-017772-zpf1xjqi 199 15 : : : cord-017772-zpf1xjqi 199 16 frequency frequency NN cord-017772-zpf1xjqi 199 17 , , , cord-017772-zpf1xjqi 199 18 risk risk NN cord-017772-zpf1xjqi 199 19 factors factor NNS cord-017772-zpf1xjqi 199 20 , , , cord-017772-zpf1xjqi 199 21 and and CC cord-017772-zpf1xjqi 199 22 outcomes outcome NNS cord-017772-zpf1xjqi 199 23 The the DT cord-017772-zpf1xjqi 199 24 frequency frequency NN cord-017772-zpf1xjqi 199 25 and and CC cord-017772-zpf1xjqi 199 26 clinical clinical JJ cord-017772-zpf1xjqi 199 27 significance significance NN cord-017772-zpf1xjqi 199 28 of of IN cord-017772-zpf1xjqi 199 29 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 199 30 complicating complicate VBG cord-017772-zpf1xjqi 199 31 critical critical JJ cord-017772-zpf1xjqi 199 32 illness illness NN cord-017772-zpf1xjqi 199 33 : : : cord-017772-zpf1xjqi 199 34 a a DT cord-017772-zpf1xjqi 199 35 systematic systematic JJ cord-017772-zpf1xjqi 199 36 review review NN cord-017772-zpf1xjqi 199 37 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 199 38 in in IN cord-017772-zpf1xjqi 199 39 the the DT cord-017772-zpf1xjqi 199 40 intensive intensive JJ cord-017772-zpf1xjqi 199 41 care care NN cord-017772-zpf1xjqi 199 42 unit unit NN cord-017772-zpf1xjqi 199 43 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 199 44 in in IN cord-017772-zpf1xjqi 199 45 patients patient NNS cord-017772-zpf1xjqi 199 46 in in IN cord-017772-zpf1xjqi 199 47 the the DT cord-017772-zpf1xjqi 199 48 medical medical JJ cord-017772-zpf1xjqi 199 49 intensive intensive JJ cord-017772-zpf1xjqi 199 50 care care NN cord-017772-zpf1xjqi 199 51 unit unit NN cord-017772-zpf1xjqi 199 52 : : : cord-017772-zpf1xjqi 199 53 bleeding bleed VBG cord-017772-zpf1xjqi 199 54 prevalence prevalence NN cord-017772-zpf1xjqi 199 55 , , , cord-017772-zpf1xjqi 199 56 transfusion transfusion NN cord-017772-zpf1xjqi 199 57 requirements requirement NNS cord-017772-zpf1xjqi 199 58 , , , cord-017772-zpf1xjqi 199 59 and and CC cord-017772-zpf1xjqi 199 60 outcome outcome NN cord-017772-zpf1xjqi 199 61 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 199 62 and and CC cord-017772-zpf1xjqi 199 63 prognosis prognosis NN cord-017772-zpf1xjqi 199 64 in in IN cord-017772-zpf1xjqi 199 65 intensive intensive JJ cord-017772-zpf1xjqi 199 66 care care NN cord-017772-zpf1xjqi 199 67 Platelet platelet NN cord-017772-zpf1xjqi 199 68 count count NN cord-017772-zpf1xjqi 199 69 decline decline NN cord-017772-zpf1xjqi 199 70 : : : cord-017772-zpf1xjqi 199 71 an an DT cord-017772-zpf1xjqi 199 72 early early JJ cord-017772-zpf1xjqi 199 73 prognostic prognostic JJ cord-017772-zpf1xjqi 199 74 marker marker NN cord-017772-zpf1xjqi 199 75 in in IN cord-017772-zpf1xjqi 199 76 critically critically RB cord-017772-zpf1xjqi 199 77 ill ill JJ cord-017772-zpf1xjqi 199 78 patients patient NNS cord-017772-zpf1xjqi 199 79 with with IN cord-017772-zpf1xjqi 200 1 prolonged prolong VBN cord-017772-zpf1xjqi 200 2 ICU ICU NNP cord-017772-zpf1xjqi 200 3 stays stay VBZ cord-017772-zpf1xjqi 200 4 Blunted blunted JJ cord-017772-zpf1xjqi 200 5 rise rise NN cord-017772-zpf1xjqi 200 6 in in IN cord-017772-zpf1xjqi 200 7 platelet platelet NN cord-017772-zpf1xjqi 200 8 count count NN cord-017772-zpf1xjqi 200 9 in in IN cord-017772-zpf1xjqi 200 10 critically critically RB cord-017772-zpf1xjqi 200 11 ill ill JJ cord-017772-zpf1xjqi 200 12 patients patient NNS cord-017772-zpf1xjqi 200 13 is be VBZ cord-017772-zpf1xjqi 200 14 associated associate VBN cord-017772-zpf1xjqi 200 15 with with IN cord-017772-zpf1xjqi 200 16 worse bad JJR cord-017772-zpf1xjqi 200 17 outcome outcome NN cord-017772-zpf1xjqi 200 18 The the DT cord-017772-zpf1xjqi 200 19 SOFA sofa NN cord-017772-zpf1xjqi 200 20 ( ( -LRB- cord-017772-zpf1xjqi 200 21 Sepsis sepsis NN cord-017772-zpf1xjqi 200 22 - - HYPH cord-017772-zpf1xjqi 200 23 related relate VBN cord-017772-zpf1xjqi 200 24 organ organ NN cord-017772-zpf1xjqi 200 25 failure failure NN cord-017772-zpf1xjqi 200 26 assessment assessment NN cord-017772-zpf1xjqi 200 27 ) ) -RRB- cord-017772-zpf1xjqi 200 28 score score NN cord-017772-zpf1xjqi 200 29 to to TO cord-017772-zpf1xjqi 200 30 describe describe VB cord-017772-zpf1xjqi 200 31 organ organ NN cord-017772-zpf1xjqi 200 32 dysfunction dysfunction NN cord-017772-zpf1xjqi 200 33 / / SYM cord-017772-zpf1xjqi 200 34 failure failure NN cord-017772-zpf1xjqi 200 35 . . . cord-017772-zpf1xjqi 201 1 On on IN cord-017772-zpf1xjqi 201 2 behalf behalf NN cord-017772-zpf1xjqi 201 3 of of IN cord-017772-zpf1xjqi 201 4 the the DT cord-017772-zpf1xjqi 201 5 working work VBG cord-017772-zpf1xjqi 201 6 group group NN cord-017772-zpf1xjqi 201 7 on on IN cord-017772-zpf1xjqi 201 8 Sepsis sepsis NN cord-017772-zpf1xjqi 201 9 - - HYPH cord-017772-zpf1xjqi 201 10 related relate VBN cord-017772-zpf1xjqi 201 11 problems problem NNS cord-017772-zpf1xjqi 201 12 of of IN cord-017772-zpf1xjqi 201 13 the the DT cord-017772-zpf1xjqi 201 14 European European NNP cord-017772-zpf1xjqi 201 15 Society Society NNP cord-017772-zpf1xjqi 201 16 of of IN cord-017772-zpf1xjqi 201 17 Intensive Intensive NNP cord-017772-zpf1xjqi 201 18 Care Care NNP cord-017772-zpf1xjqi 201 19 Medicine Medicine NNP cord-017772-zpf1xjqi 201 20 Multiple multiple JJ cord-017772-zpf1xjqi 201 21 organ organ NN cord-017772-zpf1xjqi 201 22 dysfunction dysfunction NN cord-017772-zpf1xjqi 201 23 score score NN cord-017772-zpf1xjqi 201 24 : : : cord-017772-zpf1xjqi 201 25 a a DT cord-017772-zpf1xjqi 201 26 reliable reliable JJ cord-017772-zpf1xjqi 201 27 descriptor descriptor NN cord-017772-zpf1xjqi 201 28 of of IN cord-017772-zpf1xjqi 201 29 a a DT cord-017772-zpf1xjqi 201 30 complex complex JJ cord-017772-zpf1xjqi 201 31 clinical clinical JJ cord-017772-zpf1xjqi 201 32 outcome outcome NN cord-017772-zpf1xjqi 201 33 Epidemiology epidemiology NN cord-017772-zpf1xjqi 201 34 and and CC cord-017772-zpf1xjqi 201 35 outcome outcome NN cord-017772-zpf1xjqi 201 36 of of IN cord-017772-zpf1xjqi 201 37 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 201 38 patients patient NNS cord-017772-zpf1xjqi 201 39 in in IN cord-017772-zpf1xjqi 201 40 the the DT cord-017772-zpf1xjqi 201 41 intensive intensive JJ cord-017772-zpf1xjqi 201 42 care care NN cord-017772-zpf1xjqi 201 43 unit unit NN cord-017772-zpf1xjqi 201 44 : : : cord-017772-zpf1xjqi 201 45 results result NNS cord-017772-zpf1xjqi 201 46 of of IN cord-017772-zpf1xjqi 201 47 a a DT cord-017772-zpf1xjqi 201 48 prospective prospective JJ cord-017772-zpf1xjqi 201 49 multicenter multicenter JJ cord-017772-zpf1xjqi 201 50 study study NN cord-017772-zpf1xjqi 201 51 Pseudothrombocytopenia Pseudothrombocytopenia NNP cord-017772-zpf1xjqi 201 52 due due IN cord-017772-zpf1xjqi 201 53 to to IN cord-017772-zpf1xjqi 201 54 platelet platelet NN cord-017772-zpf1xjqi 201 55 clumping clumping NN cord-017772-zpf1xjqi 201 56 : : : cord-017772-zpf1xjqi 201 57 a a DT cord-017772-zpf1xjqi 201 58 case case NN cord-017772-zpf1xjqi 201 59 report report NN cord-017772-zpf1xjqi 201 60 and and CC cord-017772-zpf1xjqi 201 61 brief brief JJ cord-017772-zpf1xjqi 201 62 review review NN cord-017772-zpf1xjqi 201 63 of of IN cord-017772-zpf1xjqi 201 64 the the DT cord-017772-zpf1xjqi 201 65 literature literature NN cord-017772-zpf1xjqi 201 66 Bleeding bleeding NN cord-017772-zpf1xjqi 201 67 and and CC cord-017772-zpf1xjqi 201 68 coagulopathies coagulopathie NNS cord-017772-zpf1xjqi 201 69 in in IN cord-017772-zpf1xjqi 201 70 critical critical JJ cord-017772-zpf1xjqi 201 71 care care NN cord-017772-zpf1xjqi 201 72 Guidelines guideline NNS cord-017772-zpf1xjqi 201 73 for for IN cord-017772-zpf1xjqi 201 74 the the DT cord-017772-zpf1xjqi 201 75 use use NN cord-017772-zpf1xjqi 201 76 of of IN cord-017772-zpf1xjqi 201 77 platelet platelet NN cord-017772-zpf1xjqi 201 78 transfusions transfusion NNS cord-017772-zpf1xjqi 201 79 Evidence evidence NN cord-017772-zpf1xjqi 201 80 - - HYPH cord-017772-zpf1xjqi 201 81 based base VBN cord-017772-zpf1xjqi 201 82 platelet platelet NN cord-017772-zpf1xjqi 201 83 transfusion transfusion NN cord-017772-zpf1xjqi 201 84 guidelines guideline NNS cord-017772-zpf1xjqi 201 85 Consensus Consensus NNP cord-017772-zpf1xjqi 201 86 on on IN cord-017772-zpf1xjqi 201 87 the the DT cord-017772-zpf1xjqi 201 88 standardization standardization NN cord-017772-zpf1xjqi 201 89 of of IN cord-017772-zpf1xjqi 201 90 terminology terminology NN cord-017772-zpf1xjqi 201 91 in in IN cord-017772-zpf1xjqi 201 92 thrombotic thrombotic JJ cord-017772-zpf1xjqi 201 93 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 201 94 purpura purpura NN cord-017772-zpf1xjqi 201 95 and and CC cord-017772-zpf1xjqi 201 96 related related JJ cord-017772-zpf1xjqi 201 97 thrombotic thrombotic JJ cord-017772-zpf1xjqi 201 98 microangiopathies microangiopathie NNS cord-017772-zpf1xjqi 201 99 Syndromes Syndromes NNPS cord-017772-zpf1xjqi 201 100 of of IN cord-017772-zpf1xjqi 201 101 thrombotic thrombotic JJ cord-017772-zpf1xjqi 201 102 microangiopathy microangiopathy NN cord-017772-zpf1xjqi 201 103 Thrombotic Thrombotic NNP cord-017772-zpf1xjqi 201 104 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 201 105 purpura purpura NN cord-017772-zpf1xjqi 201 106 Thrombotic Thrombotic NNP cord-017772-zpf1xjqi 201 107 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 201 108 purpura purpura NN cord-017772-zpf1xjqi 202 1 The the DT cord-017772-zpf1xjqi 202 2 incidence incidence NN cord-017772-zpf1xjqi 202 3 of of IN cord-017772-zpf1xjqi 202 4 thrombotic thrombotic JJ cord-017772-zpf1xjqi 202 5 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 202 6 purpurahemolytic purpurahemolytic JJ cord-017772-zpf1xjqi 202 7 uremic uremic NNP cord-017772-zpf1xjqi 202 8 syndrome syndrome NN cord-017772-zpf1xjqi 202 9 : : : cord-017772-zpf1xjqi 202 10 all all DT cord-017772-zpf1xjqi 202 11 patients patient NNS cord-017772-zpf1xjqi 202 12 , , , cord-017772-zpf1xjqi 202 13 idiopathic idiopathic JJ cord-017772-zpf1xjqi 202 14 patients patient NNS cord-017772-zpf1xjqi 202 15 , , , cord-017772-zpf1xjqi 202 16 and and CC cord-017772-zpf1xjqi 202 17 patients patient NNS cord-017772-zpf1xjqi 202 18 with with IN cord-017772-zpf1xjqi 202 19 severe severe JJ cord-017772-zpf1xjqi 202 20 ADAMTS-13 adamts-13 ADD cord-017772-zpf1xjqi 202 21 deficiency deficiency NN cord-017772-zpf1xjqi 202 22 Epidemiology epidemiology NN cord-017772-zpf1xjqi 202 23 and and CC cord-017772-zpf1xjqi 202 24 pathophysiology pathophysiology NN cord-017772-zpf1xjqi 202 25 of of IN cord-017772-zpf1xjqi 202 26 adulthood adulthood NN cord-017772-zpf1xjqi 202 27 - - HYPH cord-017772-zpf1xjqi 202 28 onset onset NN cord-017772-zpf1xjqi 202 29 thrombotic thrombotic JJ cord-017772-zpf1xjqi 202 30 microangiopathy microangiopathy NN cord-017772-zpf1xjqi 202 31 with with IN cord-017772-zpf1xjqi 202 32 severe severe JJ cord-017772-zpf1xjqi 202 33 ADAMTS13 ADAMTS13 NNP cord-017772-zpf1xjqi 202 34 deficiency deficiency NN cord-017772-zpf1xjqi 202 35 ( ( -LRB- cord-017772-zpf1xjqi 202 36 thrombotic thrombotic JJ cord-017772-zpf1xjqi 202 37 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 202 38 purpura purpura NNP cord-017772-zpf1xjqi 202 39 ) ) -RRB- cord-017772-zpf1xjqi 202 40 : : : cord-017772-zpf1xjqi 202 41 a a DT cord-017772-zpf1xjqi 202 42 cross cross JJ cord-017772-zpf1xjqi 202 43 - - JJ cord-017772-zpf1xjqi 202 44 sectional sectional JJ cord-017772-zpf1xjqi 202 45 analysis analysis NN cord-017772-zpf1xjqi 202 46 of of IN cord-017772-zpf1xjqi 202 47 the the DT cord-017772-zpf1xjqi 202 48 French french JJ cord-017772-zpf1xjqi 202 49 national national JJ cord-017772-zpf1xjqi 202 50 registry registry NN cord-017772-zpf1xjqi 202 51 for for IN cord-017772-zpf1xjqi 202 52 thrombotic thrombotic JJ cord-017772-zpf1xjqi 202 53 microangiopathy microangiopathy NN cord-017772-zpf1xjqi 202 54 Thrombotic Thrombotic NNP cord-017772-zpf1xjqi 202 55 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 202 56 purpura purpura NN cord-017772-zpf1xjqi 202 57 : : : cord-017772-zpf1xjqi 202 58 diagnostic diagnostic JJ cord-017772-zpf1xjqi 202 59 criteria criterion NNS cord-017772-zpf1xjqi 202 60 , , , cord-017772-zpf1xjqi 202 61 clinical clinical JJ cord-017772-zpf1xjqi 202 62 features feature NNS cord-017772-zpf1xjqi 202 63 , , , cord-017772-zpf1xjqi 202 64 and and CC cord-017772-zpf1xjqi 202 65 long long JJ cord-017772-zpf1xjqi 202 66 - - HYPH cord-017772-zpf1xjqi 202 67 term term NN cord-017772-zpf1xjqi 202 68 outcomes outcome NNS cord-017772-zpf1xjqi 202 69 from from IN cord-017772-zpf1xjqi 202 70 1995 1995 CD cord-017772-zpf1xjqi 202 71 through through IN cord-017772-zpf1xjqi 202 72 2015 2015 CD cord-017772-zpf1xjqi 202 73 Guidelines Guidelines NNPS cord-017772-zpf1xjqi 202 74 on on IN cord-017772-zpf1xjqi 202 75 the the DT cord-017772-zpf1xjqi 202 76 diagnosis diagnosis NN cord-017772-zpf1xjqi 202 77 and and CC cord-017772-zpf1xjqi 202 78 management management NN cord-017772-zpf1xjqi 202 79 of of IN cord-017772-zpf1xjqi 202 80 thrombotic thrombotic JJ cord-017772-zpf1xjqi 202 81 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 202 82 purpura purpura NN cord-017772-zpf1xjqi 202 83 and and CC cord-017772-zpf1xjqi 202 84 other other JJ cord-017772-zpf1xjqi 202 85 thrombotic thrombotic JJ cord-017772-zpf1xjqi 202 86 microangiopathies microangiopathie NNS cord-017772-zpf1xjqi 202 87 Comparison Comparison NNP cord-017772-zpf1xjqi 202 88 of of IN cord-017772-zpf1xjqi 202 89 plasma plasma NN cord-017772-zpf1xjqi 202 90 exchange exchange NN cord-017772-zpf1xjqi 202 91 with with IN cord-017772-zpf1xjqi 202 92 plasma plasma NN cord-017772-zpf1xjqi 202 93 infusion infusion NN cord-017772-zpf1xjqi 202 94 in in IN cord-017772-zpf1xjqi 202 95 the the DT cord-017772-zpf1xjqi 202 96 treatment treatment NN cord-017772-zpf1xjqi 202 97 of of IN cord-017772-zpf1xjqi 202 98 thrombotic thrombotic JJ cord-017772-zpf1xjqi 202 99 thrombocytopenic thrombocytopenic JJ cord-017772-zpf1xjqi 202 100 purpura purpura NN cord-017772-zpf1xjqi 202 101 . . . cord-017772-zpf1xjqi 203 1 Canadian Canadian NNP cord-017772-zpf1xjqi 203 2 Apheresis Apheresis NNP cord-017772-zpf1xjqi 203 3 Study Study NNP cord-017772-zpf1xjqi 203 4 Group Group NNP cord-017772-zpf1xjqi 203 5 Towards towards IN cord-017772-zpf1xjqi 203 6 definition definition NN cord-017772-zpf1xjqi 203 7 , , , cord-017772-zpf1xjqi 203 8 clinical clinical JJ cord-017772-zpf1xjqi 203 9 and and CC cord-017772-zpf1xjqi 203 10 laboratory laboratory NN cord-017772-zpf1xjqi 203 11 criteria criterion NNS cord-017772-zpf1xjqi 203 12 , , , cord-017772-zpf1xjqi 203 13 and and CC cord-017772-zpf1xjqi 203 14 a a DT cord-017772-zpf1xjqi 203 15 scoring scoring NN cord-017772-zpf1xjqi 203 16 system system NN cord-017772-zpf1xjqi 203 17 for for IN cord-017772-zpf1xjqi 204 1 disseminated disseminate VBN cord-017772-zpf1xjqi 204 2 intravascular intravascular JJ cord-017772-zpf1xjqi 204 3 coagulation coagulation NN cord-017772-zpf1xjqi 204 4 Disseminated disseminate VBD cord-017772-zpf1xjqi 204 5 intravascular intravascular JJ cord-017772-zpf1xjqi 204 6 coagulation coagulation NN cord-017772-zpf1xjqi 204 7 Disseminated disseminate VBD cord-017772-zpf1xjqi 204 8 intravascular intravascular JJ cord-017772-zpf1xjqi 204 9 coagulation coagulation NN cord-017772-zpf1xjqi 204 10 Epidemiology epidemiology NN cord-017772-zpf1xjqi 204 11 of of IN cord-017772-zpf1xjqi 204 12 disseminated disseminate VBN cord-017772-zpf1xjqi 204 13 intravascular intravascular JJ cord-017772-zpf1xjqi 204 14 coagulation coagulation NN cord-017772-zpf1xjqi 204 15 in in IN cord-017772-zpf1xjqi 204 16 sepsis sepsis NN cord-017772-zpf1xjqi 204 17 and and CC cord-017772-zpf1xjqi 204 18 validation validation NN cord-017772-zpf1xjqi 204 19 of of IN cord-017772-zpf1xjqi 204 20 scoring score VBG cord-017772-zpf1xjqi 204 21 systems system NNS cord-017772-zpf1xjqi 204 22 Disseminated disseminate VBD cord-017772-zpf1xjqi 204 23 intravascular intravascular JJ cord-017772-zpf1xjqi 204 24 coagulation coagulation NN cord-017772-zpf1xjqi 204 25 in in IN cord-017772-zpf1xjqi 204 26 sepsis sepsis NN cord-017772-zpf1xjqi 204 27 Trends trend NNS cord-017772-zpf1xjqi 204 28 in in IN cord-017772-zpf1xjqi 204 29 the the DT cord-017772-zpf1xjqi 204 30 incidence incidence NN cord-017772-zpf1xjqi 204 31 and and CC cord-017772-zpf1xjqi 204 32 outcomes outcome NNS cord-017772-zpf1xjqi 204 33 of of IN cord-017772-zpf1xjqi 204 34 disseminated disseminate VBN cord-017772-zpf1xjqi 204 35 intravascular intravascular JJ cord-017772-zpf1xjqi 204 36 coagulation coagulation NN cord-017772-zpf1xjqi 204 37 in in IN cord-017772-zpf1xjqi 204 38 critically critically RB cord-017772-zpf1xjqi 204 39 ill ill JJ cord-017772-zpf1xjqi 204 40 patients patient NNS cord-017772-zpf1xjqi 204 41 ( ( -LRB- cord-017772-zpf1xjqi 204 42 2004 2004 CD cord-017772-zpf1xjqi 204 43 - - SYM cord-017772-zpf1xjqi 204 44 2010 2010 CD cord-017772-zpf1xjqi 204 45 ) ) -RRB- cord-017772-zpf1xjqi 204 46 : : : cord-017772-zpf1xjqi 204 47 a a DT cord-017772-zpf1xjqi 204 48 population population NN cord-017772-zpf1xjqi 204 49 - - HYPH cord-017772-zpf1xjqi 204 50 based base VBN cord-017772-zpf1xjqi 204 51 study study NN cord-017772-zpf1xjqi 205 1 The the DT cord-017772-zpf1xjqi 205 2 scoring scoring NN cord-017772-zpf1xjqi 205 3 system system NN cord-017772-zpf1xjqi 205 4 of of IN cord-017772-zpf1xjqi 205 5 the the DT cord-017772-zpf1xjqi 205 6 scientific scientific JJ cord-017772-zpf1xjqi 205 7 and and CC cord-017772-zpf1xjqi 205 8 standardisation standardisation NN cord-017772-zpf1xjqi 205 9 committee committee NN cord-017772-zpf1xjqi 205 10 on on IN cord-017772-zpf1xjqi 205 11 disseminated disseminate VBN cord-017772-zpf1xjqi 205 12 intravascular intravascular JJ cord-017772-zpf1xjqi 205 13 coagulation coagulation NN cord-017772-zpf1xjqi 205 14 of of IN cord-017772-zpf1xjqi 205 15 the the DT cord-017772-zpf1xjqi 205 16 International International NNP cord-017772-zpf1xjqi 205 17 Society Society NNP cord-017772-zpf1xjqi 205 18 on on IN cord-017772-zpf1xjqi 205 19 Thrombosis Thrombosis NNP cord-017772-zpf1xjqi 205 20 and and CC cord-017772-zpf1xjqi 205 21 Haemostasis Haemostasis NNP cord-017772-zpf1xjqi 205 22 : : : cord-017772-zpf1xjqi 205 23 a a DT cord-017772-zpf1xjqi 205 24 5-year 5-year CD cord-017772-zpf1xjqi 205 25 overview overview NN cord-017772-zpf1xjqi 205 26 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 205 27 in in IN cord-017772-zpf1xjqi 205 28 the the DT cord-017772-zpf1xjqi 205 29 ICU ICU NNP cord-017772-zpf1xjqi 205 30 : : : cord-017772-zpf1xjqi 205 31 disseminated disseminate VBN cord-017772-zpf1xjqi 205 32 intravascular intravascular JJ cord-017772-zpf1xjqi 205 33 coagulation coagulation NN cord-017772-zpf1xjqi 205 34 and and CC cord-017772-zpf1xjqi 205 35 thrombotic thrombotic JJ cord-017772-zpf1xjqi 205 36 microangiopathies microangiopathie NNS cord-017772-zpf1xjqi 205 37 - - : cord-017772-zpf1xjqi 205 38 what what WP cord-017772-zpf1xjqi 205 39 intensivists intensivist NNS cord-017772-zpf1xjqi 205 40 need need VBP cord-017772-zpf1xjqi 205 41 to to TO cord-017772-zpf1xjqi 205 42 know know VB cord-017772-zpf1xjqi 205 43 Prospective prospective JJ cord-017772-zpf1xjqi 205 44 validation validation NN cord-017772-zpf1xjqi 205 45 of of IN cord-017772-zpf1xjqi 205 46 the the DT cord-017772-zpf1xjqi 205 47 International International NNP cord-017772-zpf1xjqi 205 48 Society Society NNP cord-017772-zpf1xjqi 205 49 of of IN cord-017772-zpf1xjqi 205 50 Thrombosis Thrombosis NNP cord-017772-zpf1xjqi 205 51 and and CC cord-017772-zpf1xjqi 205 52 Haemostasis Haemostasis NNP cord-017772-zpf1xjqi 205 53 scoring score VBG cord-017772-zpf1xjqi 205 54 system system NN cord-017772-zpf1xjqi 205 55 for for IN cord-017772-zpf1xjqi 205 56 disseminated disseminate VBN cord-017772-zpf1xjqi 205 57 intravascular intravascular JJ cord-017772-zpf1xjqi 205 58 coagulation coagulation NN cord-017772-zpf1xjqi 206 1 What what WP cord-017772-zpf1xjqi 206 2 's be VBZ cord-017772-zpf1xjqi 206 3 new new JJ cord-017772-zpf1xjqi 206 4 in in IN cord-017772-zpf1xjqi 206 5 the the DT cord-017772-zpf1xjqi 206 6 diagnostic diagnostic JJ cord-017772-zpf1xjqi 206 7 criteria criterion NNS cord-017772-zpf1xjqi 206 8 of of IN cord-017772-zpf1xjqi 206 9 disseminated disseminate VBN cord-017772-zpf1xjqi 206 10 intravascular intravascular JJ cord-017772-zpf1xjqi 206 11 coagulation coagulation NN cord-017772-zpf1xjqi 206 12 ? ? . cord-017772-zpf1xjqi 207 1 Diagnosis diagnosis NN cord-017772-zpf1xjqi 207 2 and and CC cord-017772-zpf1xjqi 207 3 treatment treatment NN cord-017772-zpf1xjqi 207 4 of of IN cord-017772-zpf1xjqi 207 5 disseminated disseminate VBN cord-017772-zpf1xjqi 207 6 intravascular intravascular JJ cord-017772-zpf1xjqi 207 7 coagulation coagulation NN cord-017772-zpf1xjqi 207 8 ( ( -LRB- cord-017772-zpf1xjqi 207 9 DIC DIC NNP cord-017772-zpf1xjqi 207 10 ) ) -RRB- cord-017772-zpf1xjqi 207 11 according accord VBG cord-017772-zpf1xjqi 207 12 to to IN cord-017772-zpf1xjqi 207 13 four four CD cord-017772-zpf1xjqi 207 14 DIC DIC NNP cord-017772-zpf1xjqi 207 15 guidelines guideline NNS cord-017772-zpf1xjqi 207 16 Efficacy Efficacy NNP cord-017772-zpf1xjqi 207 17 and and CC cord-017772-zpf1xjqi 207 18 safety safety NN cord-017772-zpf1xjqi 207 19 of of IN cord-017772-zpf1xjqi 207 20 tifacogin tifacogin NNP cord-017772-zpf1xjqi 207 21 ( ( -LRB- cord-017772-zpf1xjqi 207 22 recombinant recombinant JJ cord-017772-zpf1xjqi 207 23 tissue tissue NN cord-017772-zpf1xjqi 207 24 factor factor NN cord-017772-zpf1xjqi 207 25 pathway pathway NN cord-017772-zpf1xjqi 207 26 inhibitor inhibitor NN cord-017772-zpf1xjqi 207 27 ) ) -RRB- cord-017772-zpf1xjqi 207 28 in in IN cord-017772-zpf1xjqi 207 29 severe severe JJ cord-017772-zpf1xjqi 207 30 sepsis sepsis NN cord-017772-zpf1xjqi 207 31 : : : cord-017772-zpf1xjqi 207 32 a a DT cord-017772-zpf1xjqi 207 33 randomized randomized JJ cord-017772-zpf1xjqi 207 34 controlled control VBN cord-017772-zpf1xjqi 207 35 trial trial NN cord-017772-zpf1xjqi 207 36 Caring care VBG cord-017772-zpf1xjqi 207 37 for for IN cord-017772-zpf1xjqi 207 38 the the DT cord-017772-zpf1xjqi 207 39 critically critically RB cord-017772-zpf1xjqi 207 40 ill ill JJ cord-017772-zpf1xjqi 207 41 patient patient NN cord-017772-zpf1xjqi 207 42 . . . cord-017772-zpf1xjqi 208 1 High high JJ cord-017772-zpf1xjqi 208 2 - - HYPH cord-017772-zpf1xjqi 208 3 dose dose NN cord-017772-zpf1xjqi 208 4 antithrombin antithrombin NN cord-017772-zpf1xjqi 208 5 III III NNP cord-017772-zpf1xjqi 208 6 in in IN cord-017772-zpf1xjqi 208 7 severe severe JJ cord-017772-zpf1xjqi 208 8 sepsis sepsis NN cord-017772-zpf1xjqi 208 9 : : : cord-017772-zpf1xjqi 208 10 a a DT cord-017772-zpf1xjqi 208 11 randomized randomized JJ cord-017772-zpf1xjqi 208 12 controlled control VBN cord-017772-zpf1xjqi 208 13 trial trial NN cord-017772-zpf1xjqi 208 14 Efficacy Efficacy NNP cord-017772-zpf1xjqi 208 15 and and CC cord-017772-zpf1xjqi 208 16 safety safety NN cord-017772-zpf1xjqi 208 17 of of IN cord-017772-zpf1xjqi 208 18 recombinant recombinant JJ cord-017772-zpf1xjqi 208 19 human human NN cord-017772-zpf1xjqi 208 20 activated activate VBN cord-017772-zpf1xjqi 208 21 protein protein NN cord-017772-zpf1xjqi 208 22 C c NN cord-017772-zpf1xjqi 208 23 for for IN cord-017772-zpf1xjqi 208 24 severe severe JJ cord-017772-zpf1xjqi 208 25 sepsis sepsis NN cord-017772-zpf1xjqi 208 26 Treatment treatment NN cord-017772-zpf1xjqi 208 27 effects effect NNS cord-017772-zpf1xjqi 208 28 of of IN cord-017772-zpf1xjqi 208 29 drotrecogin drotrecogin NNP cord-017772-zpf1xjqi 208 30 alfa alfa NNP cord-017772-zpf1xjqi 208 31 ( ( -LRB- cord-017772-zpf1xjqi 208 32 activated activate VBN cord-017772-zpf1xjqi 208 33 ) ) -RRB- cord-017772-zpf1xjqi 208 34 in in IN cord-017772-zpf1xjqi 208 35 patients patient NNS cord-017772-zpf1xjqi 208 36 with with IN cord-017772-zpf1xjqi 208 37 severe severe JJ cord-017772-zpf1xjqi 208 38 sepsis sepsis NN cord-017772-zpf1xjqi 208 39 with with IN cord-017772-zpf1xjqi 208 40 or or CC cord-017772-zpf1xjqi 208 41 without without IN cord-017772-zpf1xjqi 208 42 overt overt JJ cord-017772-zpf1xjqi 208 43 disseminated disseminate VBN cord-017772-zpf1xjqi 208 44 intravascular intravascular JJ cord-017772-zpf1xjqi 208 45 coagulation coagulation NN cord-017772-zpf1xjqi 208 46 Drotrecogin Drotrecogin NNP cord-017772-zpf1xjqi 208 47 alfa alfa NNP cord-017772-zpf1xjqi 208 48 ( ( -LRB- cord-017772-zpf1xjqi 208 49 activated activate VBN cord-017772-zpf1xjqi 208 50 ) ) -RRB- cord-017772-zpf1xjqi 208 51 in in IN cord-017772-zpf1xjqi 208 52 adults adult NNS cord-017772-zpf1xjqi 208 53 with with IN cord-017772-zpf1xjqi 208 54 septic septic JJ cord-017772-zpf1xjqi 208 55 shock shock NN cord-017772-zpf1xjqi 209 1 Identifying identify VBG cord-017772-zpf1xjqi 209 2 drugs drug NNS cord-017772-zpf1xjqi 209 3 that that WDT cord-017772-zpf1xjqi 209 4 cause cause VBP cord-017772-zpf1xjqi 209 5 acute acute JJ cord-017772-zpf1xjqi 209 6 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 209 7 : : : cord-017772-zpf1xjqi 209 8 an an DT cord-017772-zpf1xjqi 209 9 analysis analysis NN cord-017772-zpf1xjqi 209 10 using use VBG cord-017772-zpf1xjqi 209 11 3 3 CD cord-017772-zpf1xjqi 209 12 distinct distinct JJ cord-017772-zpf1xjqi 209 13 methods method NNS cord-017772-zpf1xjqi 209 14 How how WRB cord-017772-zpf1xjqi 209 15 I -PRON- PRP cord-017772-zpf1xjqi 209 16 evaluate evaluate VBP cord-017772-zpf1xjqi 209 17 and and CC cord-017772-zpf1xjqi 209 18 treat treat VBP cord-017772-zpf1xjqi 209 19 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 209 20 in in IN cord-017772-zpf1xjqi 209 21 the the DT cord-017772-zpf1xjqi 209 22 intensive intensive JJ cord-017772-zpf1xjqi 209 23 care care NN cord-017772-zpf1xjqi 209 24 unit unit NN cord-017772-zpf1xjqi 209 25 patient patient NN cord-017772-zpf1xjqi 209 26 Drug drug NN cord-017772-zpf1xjqi 209 27 - - HYPH cord-017772-zpf1xjqi 209 28 induced induce VBN cord-017772-zpf1xjqi 209 29 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 209 30 in in IN cord-017772-zpf1xjqi 209 31 critically critically RB cord-017772-zpf1xjqi 209 32 ill ill JJ cord-017772-zpf1xjqi 209 33 patients patient NNS cord-017772-zpf1xjqi 209 34 Drug drug NN cord-017772-zpf1xjqi 209 35 - - HYPH cord-017772-zpf1xjqi 209 36 induced induce VBN cord-017772-zpf1xjqi 209 37 immune immune JJ cord-017772-zpf1xjqi 209 38 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 209 39 Drug drug NN cord-017772-zpf1xjqi 209 40 - - HYPH cord-017772-zpf1xjqi 209 41 induced induce VBN cord-017772-zpf1xjqi 209 42 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 209 43 : : : cord-017772-zpf1xjqi 209 44 2019 2019 CD cord-017772-zpf1xjqi 209 45 update update NN cord-017772-zpf1xjqi 209 46 of of IN cord-017772-zpf1xjqi 209 47 clinical clinical JJ cord-017772-zpf1xjqi 209 48 and and CC cord-017772-zpf1xjqi 209 49 laboratory laboratory NN cord-017772-zpf1xjqi 209 50 data datum NNS cord-017772-zpf1xjqi 209 51 Heparin Heparin NNP cord-017772-zpf1xjqi 209 52 - - HYPH cord-017772-zpf1xjqi 209 53 Induced induce VBN cord-017772-zpf1xjqi 209 54 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 209 55 Heparininduced Heparininduced NNP cord-017772-zpf1xjqi 209 56 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 209 57 in in IN cord-017772-zpf1xjqi 209 58 the the DT cord-017772-zpf1xjqi 209 59 critically critically RB cord-017772-zpf1xjqi 209 60 ill ill JJ cord-017772-zpf1xjqi 209 61 patient patient NN cord-017772-zpf1xjqi 209 62 Treatment treatment NN cord-017772-zpf1xjqi 209 63 and and CC cord-017772-zpf1xjqi 209 64 prevention prevention NN cord-017772-zpf1xjqi 209 65 of of IN cord-017772-zpf1xjqi 209 66 heparin heparin NN cord-017772-zpf1xjqi 209 67 - - HYPH cord-017772-zpf1xjqi 209 68 induced induce VBN cord-017772-zpf1xjqi 209 69 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 209 70 : : : cord-017772-zpf1xjqi 209 71 Antithrombotic Antithrombotic NNP cord-017772-zpf1xjqi 209 72 Therapy Therapy NNP cord-017772-zpf1xjqi 209 73 and and CC cord-017772-zpf1xjqi 209 74 Prevention Prevention NNP cord-017772-zpf1xjqi 209 75 of of IN cord-017772-zpf1xjqi 209 76 Thrombosis Thrombosis NNP cord-017772-zpf1xjqi 209 77 , , , cord-017772-zpf1xjqi 210 1 9th 9th JJ cord-017772-zpf1xjqi 210 2 ed ed NNP cord-017772-zpf1xjqi 210 3 : : : cord-017772-zpf1xjqi 210 4 American American NNP cord-017772-zpf1xjqi 210 5 College College NNP cord-017772-zpf1xjqi 210 6 of of IN cord-017772-zpf1xjqi 210 7 Chest Chest NNP cord-017772-zpf1xjqi 210 8 Physicians Physicians NNP cord-017772-zpf1xjqi 210 9 Evidence Evidence NNP cord-017772-zpf1xjqi 210 10 - - HYPH cord-017772-zpf1xjqi 210 11 Based Based NNP cord-017772-zpf1xjqi 210 12 Clinical Clinical NNP cord-017772-zpf1xjqi 210 13 Practice Practice NNP cord-017772-zpf1xjqi 210 14 Guidelines Guidelines NNPS cord-017772-zpf1xjqi 210 15 Temporal temporal JJ cord-017772-zpf1xjqi 210 16 aspects aspect NNS cord-017772-zpf1xjqi 210 17 of of IN cord-017772-zpf1xjqi 210 18 heparin heparin NN cord-017772-zpf1xjqi 210 19 - - HYPH cord-017772-zpf1xjqi 210 20 induced induce VBN cord-017772-zpf1xjqi 210 21 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 210 22 Impact impact NN cord-017772-zpf1xjqi 210 23 of of IN cord-017772-zpf1xjqi 210 24 the the DT cord-017772-zpf1xjqi 210 25 patient patient JJ cord-017772-zpf1xjqi 210 26 population population NN cord-017772-zpf1xjqi 210 27 on on IN cord-017772-zpf1xjqi 210 28 the the DT cord-017772-zpf1xjqi 210 29 risk risk NN cord-017772-zpf1xjqi 210 30 for for IN cord-017772-zpf1xjqi 210 31 heparininduced heparininduced JJ cord-017772-zpf1xjqi 210 32 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 210 33 Argatroban Argatroban NNP cord-017772-zpf1xjqi 210 34 in in IN cord-017772-zpf1xjqi 210 35 the the DT cord-017772-zpf1xjqi 210 36 management management NN cord-017772-zpf1xjqi 210 37 of of IN cord-017772-zpf1xjqi 210 38 heparin heparin NN cord-017772-zpf1xjqi 210 39 - - HYPH cord-017772-zpf1xjqi 210 40 induced induce VBN cord-017772-zpf1xjqi 210 41 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 210 42 : : : cord-017772-zpf1xjqi 210 43 a a DT cord-017772-zpf1xjqi 210 44 multicenter multicenter JJ cord-017772-zpf1xjqi 210 45 clinical clinical JJ cord-017772-zpf1xjqi 210 46 trial trial NN cord-017772-zpf1xjqi 210 47 Evaluation Evaluation NNP cord-017772-zpf1xjqi 210 48 of of IN cord-017772-zpf1xjqi 210 49 pretest pretest NN cord-017772-zpf1xjqi 210 50 clinical clinical JJ cord-017772-zpf1xjqi 210 51 score score NN cord-017772-zpf1xjqi 210 52 ( ( -LRB- cord-017772-zpf1xjqi 210 53 4 4 CD cord-017772-zpf1xjqi 210 54 T T NNP cord-017772-zpf1xjqi 210 55 's 's POS cord-017772-zpf1xjqi 210 56 ) ) -RRB- cord-017772-zpf1xjqi 210 57 for for IN cord-017772-zpf1xjqi 210 58 the the DT cord-017772-zpf1xjqi 210 59 diagnosis diagnosis NN cord-017772-zpf1xjqi 210 60 of of IN cord-017772-zpf1xjqi 210 61 heparin heparin NN cord-017772-zpf1xjqi 210 62 - - HYPH cord-017772-zpf1xjqi 210 63 induced induce VBN cord-017772-zpf1xjqi 210 64 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 210 65 in in IN cord-017772-zpf1xjqi 210 66 two two CD cord-017772-zpf1xjqi 210 67 clinical clinical JJ cord-017772-zpf1xjqi 210 68 settings setting NNS cord-017772-zpf1xjqi 211 1 Predictive predictive JJ cord-017772-zpf1xjqi 211 2 value value NN cord-017772-zpf1xjqi 211 3 of of IN cord-017772-zpf1xjqi 211 4 the the DT cord-017772-zpf1xjqi 211 5 4Ts 4ts JJ cord-017772-zpf1xjqi 211 6 scoring scoring NN cord-017772-zpf1xjqi 211 7 system system NN cord-017772-zpf1xjqi 211 8 for for IN cord-017772-zpf1xjqi 211 9 heparin heparin NN cord-017772-zpf1xjqi 211 10 - - HYPH cord-017772-zpf1xjqi 211 11 induced induce VBN cord-017772-zpf1xjqi 211 12 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 211 13 : : : cord-017772-zpf1xjqi 211 14 a a DT cord-017772-zpf1xjqi 211 15 systematic systematic JJ cord-017772-zpf1xjqi 211 16 review review NN cord-017772-zpf1xjqi 211 17 and and CC cord-017772-zpf1xjqi 211 18 meta meta NNP cord-017772-zpf1xjqi 211 19 - - HYPH cord-017772-zpf1xjqi 211 20 analysis analysis NN cord-017772-zpf1xjqi 211 21 Evaluating evaluate VBG cord-017772-zpf1xjqi 211 22 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 211 23 during during IN cord-017772-zpf1xjqi 211 24 heparin heparin NN cord-017772-zpf1xjqi 211 25 therapy therapy NN cord-017772-zpf1xjqi 212 1 A a DT cord-017772-zpf1xjqi 212 2 prospective prospective JJ cord-017772-zpf1xjqi 212 3 , , , cord-017772-zpf1xjqi 212 4 observational observational JJ cord-017772-zpf1xjqi 212 5 registry registry NN cord-017772-zpf1xjqi 212 6 of of IN cord-017772-zpf1xjqi 212 7 patients patient NNS cord-017772-zpf1xjqi 212 8 with with IN cord-017772-zpf1xjqi 212 9 severe severe JJ cord-017772-zpf1xjqi 212 10 sepsis sepsis NN cord-017772-zpf1xjqi 213 1 : : : cord-017772-zpf1xjqi 213 2 the the DT cord-017772-zpf1xjqi 213 3 Canadian Canadian NNP cord-017772-zpf1xjqi 213 4 Sepsis Sepsis NNP cord-017772-zpf1xjqi 213 5 Treatment Treatment NNP cord-017772-zpf1xjqi 213 6 and and CC cord-017772-zpf1xjqi 213 7 Response Response NNP cord-017772-zpf1xjqi 213 8 Registry Registry NNP cord-017772-zpf1xjqi 213 9 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 213 10 is be VBZ cord-017772-zpf1xjqi 213 11 associated associate VBN cord-017772-zpf1xjqi 213 12 with with IN cord-017772-zpf1xjqi 213 13 a a DT cord-017772-zpf1xjqi 213 14 dysregulated dysregulate VBN cord-017772-zpf1xjqi 213 15 host host NN cord-017772-zpf1xjqi 213 16 response response NN cord-017772-zpf1xjqi 213 17 in in IN cord-017772-zpf1xjqi 213 18 critically critically RB cord-017772-zpf1xjqi 213 19 ill ill JJ cord-017772-zpf1xjqi 213 20 sepsis sepsis NN cord-017772-zpf1xjqi 213 21 patients patient NNS cord-017772-zpf1xjqi 213 22 Is be VBZ cord-017772-zpf1xjqi 213 23 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 213 24 an an DT cord-017772-zpf1xjqi 213 25 early early JJ cord-017772-zpf1xjqi 213 26 prognostic prognostic JJ cord-017772-zpf1xjqi 213 27 marker marker NN cord-017772-zpf1xjqi 213 28 in in IN cord-017772-zpf1xjqi 213 29 septic septic JJ cord-017772-zpf1xjqi 213 30 shock shock NN cord-017772-zpf1xjqi 213 31 ? ? . cord-017772-zpf1xjqi 214 1 Sepsisassociated sepsisassociated JJ cord-017772-zpf1xjqi 214 2 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 215 1 Surviving survive VBG cord-017772-zpf1xjqi 215 2 Sepsis Sepsis NNP cord-017772-zpf1xjqi 215 3 campaign campaign NN cord-017772-zpf1xjqi 215 4 : : : cord-017772-zpf1xjqi 215 5 international international JJ cord-017772-zpf1xjqi 215 6 guidelines guideline NNS cord-017772-zpf1xjqi 215 7 for for IN cord-017772-zpf1xjqi 215 8 Management Management NNP cord-017772-zpf1xjqi 215 9 of of IN cord-017772-zpf1xjqi 215 10 Sepsis Sepsis NNP cord-017772-zpf1xjqi 215 11 and and CC cord-017772-zpf1xjqi 215 12 Septic Septic NNP cord-017772-zpf1xjqi 215 13 Shock shock NN cord-017772-zpf1xjqi 215 14 : : : cord-017772-zpf1xjqi 216 1 2016 2016 CD cord-017772-zpf1xjqi 216 2 Complications complication NNS cord-017772-zpf1xjqi 216 3 of of IN cord-017772-zpf1xjqi 216 4 massive massive JJ cord-017772-zpf1xjqi 216 5 transfusion transfusion NN cord-017772-zpf1xjqi 216 6 Damage damage NN cord-017772-zpf1xjqi 216 7 control control NN cord-017772-zpf1xjqi 216 8 resuscitation resuscitation NN cord-017772-zpf1xjqi 216 9 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 216 10 and and CC cord-017772-zpf1xjqi 216 11 extracorporeal extracorporeal JJ cord-017772-zpf1xjqi 216 12 membrane membrane NN cord-017772-zpf1xjqi 216 13 oxygenation oxygenation NN cord-017772-zpf1xjqi 216 14 in in IN cord-017772-zpf1xjqi 216 15 adults adult NNS cord-017772-zpf1xjqi 216 16 with with IN cord-017772-zpf1xjqi 216 17 acute acute JJ cord-017772-zpf1xjqi 216 18 respiratory respiratory JJ cord-017772-zpf1xjqi 216 19 failure failure NN cord-017772-zpf1xjqi 216 20 : : : cord-017772-zpf1xjqi 217 1 a a DT cord-017772-zpf1xjqi 217 2 cohort cohort NN cord-017772-zpf1xjqi 217 3 study study NN cord-017772-zpf1xjqi 217 4 Extracorporeal extracorporeal JJ cord-017772-zpf1xjqi 217 5 membrane membrane NN cord-017772-zpf1xjqi 217 6 oxygenation oxygenation NN cord-017772-zpf1xjqi 217 7 for for IN cord-017772-zpf1xjqi 217 8 severe severe JJ cord-017772-zpf1xjqi 217 9 acute acute JJ cord-017772-zpf1xjqi 217 10 respiratory respiratory JJ cord-017772-zpf1xjqi 217 11 distress distress NN cord-017772-zpf1xjqi 217 12 syndrome syndrome NN cord-017772-zpf1xjqi 217 13 Thrombocytopenia Thrombocytopenia NNP cord-017772-zpf1xjqi 217 14 in in IN cord-017772-zpf1xjqi 217 15 patients patient NNS cord-017772-zpf1xjqi 217 16 treated treat VBN cord-017772-zpf1xjqi 217 17 with with IN cord-017772-zpf1xjqi 217 18 heparin heparin NN cord-017772-zpf1xjqi 217 19 , , , cord-017772-zpf1xjqi 217 20 combination combination NN cord-017772-zpf1xjqi 217 21 antiplatelet antiplatelet NN cord-017772-zpf1xjqi 217 22 therapy therapy NN cord-017772-zpf1xjqi 217 23 , , , cord-017772-zpf1xjqi 217 24 and and CC cord-017772-zpf1xjqi 217 25 intra intra JJ cord-017772-zpf1xjqi 217 26 - - JJ cord-017772-zpf1xjqi 217 27 aortic aortic JJ cord-017772-zpf1xjqi 217 28 balloon balloon NN cord-017772-zpf1xjqi 217 29 pump pump NN cord-017772-zpf1xjqi 217 30 counterpulsation counterpulsation NN cord-017772-zpf1xjqi 217 31 Clinical clinical JJ cord-017772-zpf1xjqi 217 32 implications implication NNS cord-017772-zpf1xjqi 217 33 of of IN cord-017772-zpf1xjqi 217 34 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 217 35 among among IN cord-017772-zpf1xjqi 217 36 patients patient NNS cord-017772-zpf1xjqi 217 37 undergoing undergo VBG cord-017772-zpf1xjqi 217 38 intra intra JJ cord-017772-zpf1xjqi 217 39 - - JJ cord-017772-zpf1xjqi 217 40 aortic aortic JJ cord-017772-zpf1xjqi 217 41 balloon balloon NN cord-017772-zpf1xjqi 217 42 pump pump NN cord-017772-zpf1xjqi 217 43 counterpulsation counterpulsation NN cord-017772-zpf1xjqi 217 44 in in IN cord-017772-zpf1xjqi 217 45 the the DT cord-017772-zpf1xjqi 217 46 coronary coronary JJ cord-017772-zpf1xjqi 217 47 care care NN cord-017772-zpf1xjqi 217 48 unit unit NN cord-017772-zpf1xjqi 217 49 Platelet platelet NN cord-017772-zpf1xjqi 217 50 transfusions transfusion NNS cord-017772-zpf1xjqi 217 51 for for IN cord-017772-zpf1xjqi 217 52 critically critically RB cord-017772-zpf1xjqi 217 53 ill ill JJ cord-017772-zpf1xjqi 217 54 patients patient NNS cord-017772-zpf1xjqi 217 55 with with IN cord-017772-zpf1xjqi 217 56 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 218 1 The the DT cord-017772-zpf1xjqi 218 2 threshold threshold NN cord-017772-zpf1xjqi 218 3 for for IN cord-017772-zpf1xjqi 218 4 prophylactic prophylactic JJ cord-017772-zpf1xjqi 218 5 platelet platelet NN cord-017772-zpf1xjqi 218 6 transfusions transfusion NNS cord-017772-zpf1xjqi 218 7 in in IN cord-017772-zpf1xjqi 218 8 adults adult NNS cord-017772-zpf1xjqi 218 9 with with IN cord-017772-zpf1xjqi 218 10 acute acute JJ cord-017772-zpf1xjqi 218 11 myeloid myeloid NN cord-017772-zpf1xjqi 218 12 leukemia leukemia NN cord-017772-zpf1xjqi 218 13 Gruppo Gruppo NNP cord-017772-zpf1xjqi 218 14 Italiano Italiano NNP cord-017772-zpf1xjqi 219 1 Malattie Malattie NNP cord-017772-zpf1xjqi 219 2 Ematologiche Ematologiche NNP cord-017772-zpf1xjqi 219 3 Maligne Maligne NNP cord-017772-zpf1xjqi 220 1 dell'Adulto dell'Adulto NNP cord-017772-zpf1xjqi 220 2 Comparison comparison NN cord-017772-zpf1xjqi 220 3 of of IN cord-017772-zpf1xjqi 220 4 different different JJ cord-017772-zpf1xjqi 220 5 platelet platelet NN cord-017772-zpf1xjqi 220 6 count count NN cord-017772-zpf1xjqi 220 7 thresholds threshold NNS cord-017772-zpf1xjqi 220 8 to to TO cord-017772-zpf1xjqi 220 9 guide guide VB cord-017772-zpf1xjqi 220 10 administration administration NN cord-017772-zpf1xjqi 220 11 of of IN cord-017772-zpf1xjqi 220 12 prophylactic prophylactic JJ cord-017772-zpf1xjqi 220 13 platelet platelet NN cord-017772-zpf1xjqi 220 14 transfusion transfusion NN cord-017772-zpf1xjqi 220 15 for for IN cord-017772-zpf1xjqi 220 16 preventing prevent VBG cord-017772-zpf1xjqi 220 17 bleeding bleed VBG cord-017772-zpf1xjqi 220 18 in in IN cord-017772-zpf1xjqi 220 19 people people NNS cord-017772-zpf1xjqi 220 20 with with IN cord-017772-zpf1xjqi 220 21 haematological haematological JJ cord-017772-zpf1xjqi 220 22 disorders disorder NNS cord-017772-zpf1xjqi 220 23 after after IN cord-017772-zpf1xjqi 220 24 myelosuppressive myelosuppressive NNP cord-017772-zpf1xjqi 220 25 chemotherapy chemotherapy NN cord-017772-zpf1xjqi 220 26 or or CC cord-017772-zpf1xjqi 220 27 stem stem NN cord-017772-zpf1xjqi 220 28 cell cell NN cord-017772-zpf1xjqi 220 29 transplantation transplantation NN cord-017772-zpf1xjqi 220 30 Platelet platelet NN cord-017772-zpf1xjqi 220 31 transfusion transfusion NN cord-017772-zpf1xjqi 220 32 for for IN cord-017772-zpf1xjqi 220 33 patients patient NNS cord-017772-zpf1xjqi 220 34 with with IN cord-017772-zpf1xjqi 220 35 Cancer cancer NN cord-017772-zpf1xjqi 220 36 : : : cord-017772-zpf1xjqi 220 37 American American NNP cord-017772-zpf1xjqi 220 38 Society Society NNP cord-017772-zpf1xjqi 220 39 of of IN cord-017772-zpf1xjqi 220 40 Clinical Clinical NNP cord-017772-zpf1xjqi 220 41 Oncology Oncology NNP cord-017772-zpf1xjqi 220 42 Clinical Clinical NNP cord-017772-zpf1xjqi 220 43 Practice Practice NNP cord-017772-zpf1xjqi 220 44 Guideline Guideline NNP cord-017772-zpf1xjqi 221 1 Update update VB cord-017772-zpf1xjqi 221 2 Fresh fresh JJ cord-017772-zpf1xjqi 221 3 frozen frozen JJ cord-017772-zpf1xjqi 221 4 plasma plasma NN cord-017772-zpf1xjqi 221 5 and and CC cord-017772-zpf1xjqi 221 6 platelet platelet NN cord-017772-zpf1xjqi 221 7 transfusion transfusion NN cord-017772-zpf1xjqi 221 8 for for IN cord-017772-zpf1xjqi 221 9 nonbleeding nonbleede VBG cord-017772-zpf1xjqi 221 10 patients patient NNS cord-017772-zpf1xjqi 221 11 in in IN cord-017772-zpf1xjqi 221 12 the the DT cord-017772-zpf1xjqi 221 13 intensive intensive JJ cord-017772-zpf1xjqi 221 14 care care NN cord-017772-zpf1xjqi 221 15 unit unit NN cord-017772-zpf1xjqi 221 16 : : : cord-017772-zpf1xjqi 221 17 benefit benefit NN cord-017772-zpf1xjqi 221 18 or or CC cord-017772-zpf1xjqi 221 19 harm harm NN cord-017772-zpf1xjqi 221 20 ? ? . cord-017772-zpf1xjqi 222 1 Platelet platelet NN cord-017772-zpf1xjqi 222 2 transfusion transfusion NN cord-017772-zpf1xjqi 222 3 : : : cord-017772-zpf1xjqi 222 4 a a DT cord-017772-zpf1xjqi 222 5 clinical clinical JJ cord-017772-zpf1xjqi 222 6 practice practice NN cord-017772-zpf1xjqi 222 7 guideline guideline NN cord-017772-zpf1xjqi 222 8 from from IN cord-017772-zpf1xjqi 222 9 the the DT cord-017772-zpf1xjqi 222 10 AABB AABB NNP cord-017772-zpf1xjqi 222 11 Comparison comparison NN cord-017772-zpf1xjqi 222 12 of of IN cord-017772-zpf1xjqi 222 13 different different JJ cord-017772-zpf1xjqi 222 14 platelet platelet NN cord-017772-zpf1xjqi 222 15 transfusion transfusion NN cord-017772-zpf1xjqi 222 16 thresholds threshold NNS cord-017772-zpf1xjqi 222 17 prior prior RB cord-017772-zpf1xjqi 222 18 to to IN cord-017772-zpf1xjqi 222 19 insertion insertion NN cord-017772-zpf1xjqi 222 20 of of IN cord-017772-zpf1xjqi 222 21 central central JJ cord-017772-zpf1xjqi 222 22 lines line NNS cord-017772-zpf1xjqi 222 23 in in IN cord-017772-zpf1xjqi 222 24 patients patient NNS cord-017772-zpf1xjqi 222 25 with with IN cord-017772-zpf1xjqi 222 26 thrombocytopenia thrombocytopenia NN cord-017772-zpf1xjqi 222 27 Complications complication NNS cord-017772-zpf1xjqi 222 28 of of IN cord-017772-zpf1xjqi 222 29 thoracentesis thoracentesis NN cord-017772-zpf1xjqi 222 30 : : : cord-017772-zpf1xjqi 222 31 incidence incidence NN cord-017772-zpf1xjqi 222 32 , , , cord-017772-zpf1xjqi 222 33 risk risk NN cord-017772-zpf1xjqi 222 34 factors factor NNS cord-017772-zpf1xjqi 222 35 , , , cord-017772-zpf1xjqi 222 36 and and CC cord-017772-zpf1xjqi 222 37 strategies strategy NNS cord-017772-zpf1xjqi 222 38 for for IN cord-017772-zpf1xjqi 222 39 prevention prevention NN