id	sid	tid	token	lemma	pos
cord-252230-s1qd3x1b	1	1	key	key	JJ
cord-252230-s1qd3x1b	1	2	:	:	:
cord-252230-s1qd3x1b	1	3	cord-252230-s1qd3x1b	cord-252230-s1qd3x1b	NN
cord-252230-s1qd3x1b	1	4	authors	author	NNS
cord-252230-s1qd3x1b	1	5	:	:	:
cord-252230-s1qd3x1b	1	6	Cadwell	Cadwell	NNP
cord-252230-s1qd3x1b	1	7	,	,	,
cord-252230-s1qd3x1b	1	8	Ken	Ken	NNP
cord-252230-s1qd3x1b	1	9	;	;	:
cord-252230-s1qd3x1b	1	10	Debnath	Debnath	NNP
cord-252230-s1qd3x1b	1	11	,	,	,
cord-252230-s1qd3x1b	1	12	Jayanta	Jayanta	NNP
cord-252230-s1qd3x1b	1	13	title	title	NN
cord-252230-s1qd3x1b	1	14	:	:	:
cord-252230-s1qd3x1b	2	1	Beyond	beyond	IN
cord-252230-s1qd3x1b	2	2	self	self	NN
cord-252230-s1qd3x1b	2	3	-	-	HYPH
cord-252230-s1qd3x1b	2	4	eating	eat	VBG
cord-252230-s1qd3x1b	2	5	:	:	:
cord-252230-s1qd3x1b	2	6	The	the	DT
cord-252230-s1qd3x1b	2	7	control	control	NN
cord-252230-s1qd3x1b	2	8	of	of	IN
cord-252230-s1qd3x1b	2	9	nonautophagic	nonautophagic	JJ
cord-252230-s1qd3x1b	2	10	functions	function	NNS
cord-252230-s1qd3x1b	2	11	and	and	CC
cord-252230-s1qd3x1b	2	12	signaling	signal	VBG
cord-252230-s1qd3x1b	2	13	pathways	pathway	NNS
cord-252230-s1qd3x1b	2	14	by	by	IN
cord-252230-s1qd3x1b	2	15	autophagy	autophagy	NN
cord-252230-s1qd3x1b	2	16	-	-	HYPH
cord-252230-s1qd3x1b	2	17	related	relate	VBN
cord-252230-s1qd3x1b	2	18	proteins	protein	NNS
cord-252230-s1qd3x1b	2	19	date	date	NN
cord-252230-s1qd3x1b	2	20	:	:	:
cord-252230-s1qd3x1b	2	21	2018	2018	CD
cord-252230-s1qd3x1b	2	22	-	-	HYPH
cord-252230-s1qd3x1b	2	23	03	03	CD
cord-252230-s1qd3x1b	2	24	-	-	HYPH
cord-252230-s1qd3x1b	2	25	05	05	CD
cord-252230-s1qd3x1b	2	26	journal	journal	NN
cord-252230-s1qd3x1b	2	27	:	:	:
cord-252230-s1qd3x1b	2	28	J	J	NNP
cord-252230-s1qd3x1b	2	29	Cell	Cell	NNP
cord-252230-s1qd3x1b	2	30	Biol	Biol	NNP
cord-252230-s1qd3x1b	2	31	DOI	DOI	NNP
cord-252230-s1qd3x1b	2	32	:	:	:
cord-252230-s1qd3x1b	3	1	10.1083	10.1083	CD
cord-252230-s1qd3x1b	3	2	/	/	SYM
cord-252230-s1qd3x1b	3	3	jcb.201706157	jcb.201706157	XX
cord-252230-s1qd3x1b	4	1	sha	sha	NNP
cord-252230-s1qd3x1b	4	2	:	:	:
cord-252230-s1qd3x1b	5	1	f7748ce96d52eeafe6b08a42b2f9f1774b373f78	f7748ce96d52eeafe6b08a42b2f9f1774b373f78	NNP
cord-252230-s1qd3x1b	5	2	doc_id	doc_id	CD
cord-252230-s1qd3x1b	5	3	:	:	:
cord-252230-s1qd3x1b	6	1	252230	252230	CD
cord-252230-s1qd3x1b	6	2	cord_uid	cord_uid	NNS
cord-252230-s1qd3x1b	6	3	:	:	:
cord-252230-s1qd3x1b	6	4	s1qd3x1b	s1qd3x1b	NNS
cord-252230-s1qd3x1b	7	1	The	the	DT
cord-252230-s1qd3x1b	7	2	identification	identification	NN
cord-252230-s1qd3x1b	7	3	of	of	IN
cord-252230-s1qd3x1b	7	4	conserved	conserved	JJ
cord-252230-s1qd3x1b	7	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	7	6	-	-	HYPH
cord-252230-s1qd3x1b	7	7	related	relate	VBN
cord-252230-s1qd3x1b	7	8	proteins	protein	NNS
cord-252230-s1qd3x1b	7	9	(	(	-LRB-
cord-252230-s1qd3x1b	7	10	ATGs	atg	NNS
cord-252230-s1qd3x1b	7	11	)	)	-RRB-
cord-252230-s1qd3x1b	7	12	that	that	WDT
cord-252230-s1qd3x1b	7	13	mediate	mediate	VBP
cord-252230-s1qd3x1b	7	14	bulk	bulk	JJ
cord-252230-s1qd3x1b	7	15	degradation	degradation	NN
cord-252230-s1qd3x1b	7	16	of	of	IN
cord-252230-s1qd3x1b	7	17	cytosolic	cytosolic	JJ
cord-252230-s1qd3x1b	7	18	material	material	NN
cord-252230-s1qd3x1b	7	19	laid	lay	VBD
cord-252230-s1qd3x1b	7	20	the	the	DT
cord-252230-s1qd3x1b	7	21	foundation	foundation	NN
cord-252230-s1qd3x1b	7	22	for	for	IN
cord-252230-s1qd3x1b	7	23	breakthroughs	breakthrough	NNS
cord-252230-s1qd3x1b	7	24	linking	link	VBG
cord-252230-s1qd3x1b	7	25	autophagy	autophagy	NN
cord-252230-s1qd3x1b	7	26	to	to	IN
cord-252230-s1qd3x1b	7	27	a	a	DT
cord-252230-s1qd3x1b	7	28	litany	litany	JJ
cord-252230-s1qd3x1b	7	29	of	of	IN
cord-252230-s1qd3x1b	7	30	physiological	physiological	JJ
cord-252230-s1qd3x1b	7	31	processes	process	NNS
cord-252230-s1qd3x1b	7	32	and	and	CC
cord-252230-s1qd3x1b	7	33	disease	disease	NN
cord-252230-s1qd3x1b	7	34	conditions	condition	NNS
cord-252230-s1qd3x1b	7	35	.	.	.
cord-252230-s1qd3x1b	8	1	Recent	recent	JJ
cord-252230-s1qd3x1b	8	2	discoveries	discovery	NNS
cord-252230-s1qd3x1b	8	3	are	be	VBP
cord-252230-s1qd3x1b	8	4	revealing	reveal	VBG
cord-252230-s1qd3x1b	8	5	that	that	IN
cord-252230-s1qd3x1b	8	6	these	these	DT
cord-252230-s1qd3x1b	8	7	same	same	JJ
cord-252230-s1qd3x1b	8	8	ATGs	atg	NNS
cord-252230-s1qd3x1b	8	9	orchestrate	orchestrate	VBP
cord-252230-s1qd3x1b	8	10	processes	process	NNS
cord-252230-s1qd3x1b	8	11	that	that	WDT
cord-252230-s1qd3x1b	8	12	are	be	VBP
cord-252230-s1qd3x1b	8	13	related	relate	VBN
cord-252230-s1qd3x1b	8	14	to	to	IN
cord-252230-s1qd3x1b	8	15	,	,	,
cord-252230-s1qd3x1b	8	16	and	and	CC
cord-252230-s1qd3x1b	8	17	yet	yet	CC
cord-252230-s1qd3x1b	8	18	clearly	clearly	RB
cord-252230-s1qd3x1b	8	19	distinct	distinct	JJ
cord-252230-s1qd3x1b	8	20	from	from	IN
cord-252230-s1qd3x1b	8	21	,	,	,
cord-252230-s1qd3x1b	8	22	classic	classic	JJ
cord-252230-s1qd3x1b	8	23	autophagy	autophagy	NN
cord-252230-s1qd3x1b	8	24	.	.	.
cord-252230-s1qd3x1b	9	1	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	9	2	-	-	HYPH
cord-252230-s1qd3x1b	9	3	related	relate	VBN
cord-252230-s1qd3x1b	9	4	functions	function	NNS
cord-252230-s1qd3x1b	9	5	include	include	VBP
cord-252230-s1qd3x1b	9	6	secretion	secretion	NN
cord-252230-s1qd3x1b	9	7	,	,	,
cord-252230-s1qd3x1b	9	8	trafficking	trafficking	NN
cord-252230-s1qd3x1b	9	9	of	of	IN
cord-252230-s1qd3x1b	9	10	phagocytosed	phagocytosed	JJ
cord-252230-s1qd3x1b	9	11	material	material	NN
cord-252230-s1qd3x1b	9	12	,	,	,
cord-252230-s1qd3x1b	9	13	replication	replication	NN
cord-252230-s1qd3x1b	9	14	and	and	CC
cord-252230-s1qd3x1b	9	15	egress	egress	NN
cord-252230-s1qd3x1b	9	16	of	of	IN
cord-252230-s1qd3x1b	9	17	viral	viral	JJ
cord-252230-s1qd3x1b	9	18	particles	particle	NNS
cord-252230-s1qd3x1b	9	19	,	,	,
cord-252230-s1qd3x1b	9	20	and	and	CC
cord-252230-s1qd3x1b	9	21	regulation	regulation	NN
cord-252230-s1qd3x1b	9	22	of	of	IN
cord-252230-s1qd3x1b	9	23	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	9	24	and	and	CC
cord-252230-s1qd3x1b	9	25	immune	immune	JJ
cord-252230-s1qd3x1b	9	26	signaling	signaling	NN
cord-252230-s1qd3x1b	9	27	cascades	cascade	NNS
cord-252230-s1qd3x1b	9	28	.	.	.
cord-252230-s1qd3x1b	10	1	Here	here	RB
cord-252230-s1qd3x1b	10	2	,	,	,
cord-252230-s1qd3x1b	10	3	we	-PRON-	PRP
cord-252230-s1qd3x1b	10	4	define	define	VBP
cord-252230-s1qd3x1b	10	5	common	common	JJ
cord-252230-s1qd3x1b	10	6	processes	process	NNS
cord-252230-s1qd3x1b	10	7	dependent	dependent	JJ
cord-252230-s1qd3x1b	10	8	on	on	IN
cord-252230-s1qd3x1b	10	9	ATGs	atg	NNS
cord-252230-s1qd3x1b	10	10	,	,	,
cord-252230-s1qd3x1b	10	11	and	and	CC
cord-252230-s1qd3x1b	10	12	discuss	discuss	VB
cord-252230-s1qd3x1b	10	13	the	the	DT
cord-252230-s1qd3x1b	10	14	challenges	challenge	NNS
cord-252230-s1qd3x1b	10	15	in	in	IN
cord-252230-s1qd3x1b	10	16	mechanistically	mechanistically	RB
cord-252230-s1qd3x1b	10	17	separating	separate	VBG
cord-252230-s1qd3x1b	10	18	autophagy	autophagy	NN
cord-252230-s1qd3x1b	10	19	from	from	IN
cord-252230-s1qd3x1b	10	20	these	these	DT
cord-252230-s1qd3x1b	10	21	related	related	JJ
cord-252230-s1qd3x1b	10	22	pathways	pathway	NNS
cord-252230-s1qd3x1b	10	23	.	.	.
cord-252230-s1qd3x1b	11	1	Elucidating	elucidate	VBG
cord-252230-s1qd3x1b	11	2	the	the	DT
cord-252230-s1qd3x1b	11	3	molecular	molecular	JJ
cord-252230-s1qd3x1b	11	4	events	event	NNS
cord-252230-s1qd3x1b	11	5	that	that	WDT
cord-252230-s1qd3x1b	11	6	distinguish	distinguish	VBP
cord-252230-s1qd3x1b	11	7	how	how	WRB
cord-252230-s1qd3x1b	11	8	individual	individual	JJ
cord-252230-s1qd3x1b	11	9	ATGs	atg	NNS
cord-252230-s1qd3x1b	11	10	function	function	NN
cord-252230-s1qd3x1b	11	11	promises	promise	NNS
cord-252230-s1qd3x1b	11	12	to	to	TO
cord-252230-s1qd3x1b	11	13	improve	improve	VB
cord-252230-s1qd3x1b	11	14	our	-PRON-	PRP$
cord-252230-s1qd3x1b	11	15	understanding	understanding	NN
cord-252230-s1qd3x1b	11	16	of	of	IN
cord-252230-s1qd3x1b	11	17	the	the	DT
cord-252230-s1qd3x1b	11	18	origin	origin	NN
cord-252230-s1qd3x1b	11	19	of	of	IN
cord-252230-s1qd3x1b	11	20	diseases	disease	NNS
cord-252230-s1qd3x1b	11	21	ranging	range	VBG
cord-252230-s1qd3x1b	11	22	from	from	IN
cord-252230-s1qd3x1b	11	23	autoimmunity	autoimmunity	NN
cord-252230-s1qd3x1b	11	24	to	to	IN
cord-252230-s1qd3x1b	11	25	cancer	cancer	NN
cord-252230-s1qd3x1b	11	26	.	.	.
cord-252230-s1qd3x1b	12	1	Twenty	twenty	CD
cord-252230-s1qd3x1b	12	2	five	five	CD
cord-252230-s1qd3x1b	12	3	years	year	NNS
cord-252230-s1qd3x1b	12	4	ago	ago	RB
cord-252230-s1qd3x1b	12	5	in	in	IN
cord-252230-s1qd3x1b	12	6	the	the	DT
cord-252230-s1qd3x1b	12	7	Journal	Journal	NNP
cord-252230-s1qd3x1b	12	8	of	of	IN
cord-252230-s1qd3x1b	12	9	Cell	Cell	NNP
cord-252230-s1qd3x1b	12	10	Biology	Biology	NNP
cord-252230-s1qd3x1b	12	11	,	,	,
cord-252230-s1qd3x1b	12	12	Professor	Professor	NNP
cord-252230-s1qd3x1b	12	13	Yoshinori	Yoshinori	NNP
cord-252230-s1qd3x1b	12	14	Ohsumi	Ohsumi	NNP
cord-252230-s1qd3x1b	12	15	and	and	CC
cord-252230-s1qd3x1b	12	16	colleagues	colleague	NNS
cord-252230-s1qd3x1b	12	17	published	publish	VBD
cord-252230-s1qd3x1b	12	18	the	the	DT
cord-252230-s1qd3x1b	12	19	first	first	JJ
cord-252230-s1qd3x1b	12	20	of	of	IN
cord-252230-s1qd3x1b	12	21	several	several	JJ
cord-252230-s1qd3x1b	12	22	landmark	landmark	NN
cord-252230-s1qd3x1b	12	23	papers	paper	NNS
cord-252230-s1qd3x1b	12	24	demonstrating	demonstrate	VBG
cord-252230-s1qd3x1b	12	25	molecular	molecular	JJ
cord-252230-s1qd3x1b	12	26	control	control	NN
cord-252230-s1qd3x1b	12	27	of	of	IN
cord-252230-s1qd3x1b	12	28	macroautophagy	macroautophagy	NNS
cord-252230-s1qd3x1b	12	29	in	in	IN
cord-252230-s1qd3x1b	12	30	response	response	NN
cord-252230-s1qd3x1b	12	31	to	to	IN
cord-252230-s1qd3x1b	12	32	nutrient	nutrient	NN
cord-252230-s1qd3x1b	12	33	starvation	starvation	NN
cord-252230-s1qd3x1b	12	34	in	in	IN
cord-252230-s1qd3x1b	12	35	Saccharomyces	Saccharomyces	NNP
cord-252230-s1qd3x1b	12	36	cerevisiae	cerevisiae	NNS
cord-252230-s1qd3x1b	12	37	(	(	-LRB-
cord-252230-s1qd3x1b	12	38	Takeshige	Takeshige	NNP
cord-252230-s1qd3x1b	12	39	et	et	FW
cord-252230-s1qd3x1b	12	40	al	al	NNP
cord-252230-s1qd3x1b	12	41	.	.	NNP
cord-252230-s1qd3x1b	12	42	,	,	,
cord-252230-s1qd3x1b	12	43	1992	1992	CD
cord-252230-s1qd3x1b	12	44	)	)	-RRB-
cord-252230-s1qd3x1b	12	45	.	.	.
cord-252230-s1qd3x1b	13	1	Thereafter	thereafter	RB
cord-252230-s1qd3x1b	13	2	,	,	,
cord-252230-s1qd3x1b	13	3	several	several	JJ
cord-252230-s1qd3x1b	13	4	groups	group	NNS
cord-252230-s1qd3x1b	13	5	identified	identify	VBD
cord-252230-s1qd3x1b	13	6	autophagy	autophagy	NN
cord-252230-s1qd3x1b	13	7	-	-	HYPH
cord-252230-s1qd3x1b	13	8	related	relate	VBN
cord-252230-s1qd3x1b	13	9	proteins	protein	NNS
cord-252230-s1qd3x1b	13	10	(	(	-LRB-
cord-252230-s1qd3x1b	13	11	ATGs	atg	NNS
cord-252230-s1qd3x1b	13	12	)	)	-RRB-
cord-252230-s1qd3x1b	13	13	,	,	,
cord-252230-s1qd3x1b	13	14	evolutionarily	evolutionarily	RB
cord-252230-s1qd3x1b	13	15	conserved	conserved	JJ
cord-252230-s1qd3x1b	13	16	molecules	molecule	NNS
cord-252230-s1qd3x1b	13	17	that	that	WDT
cord-252230-s1qd3x1b	13	18	control	control	VBP
cord-252230-s1qd3x1b	13	19	fundamental	fundamental	JJ
cord-252230-s1qd3x1b	13	20	aspects	aspect	NNS
cord-252230-s1qd3x1b	13	21	of	of	IN
cord-252230-s1qd3x1b	13	22	the	the	DT
cord-252230-s1qd3x1b	13	23	macroautophagy	macroautophagy	NNP
cord-252230-s1qd3x1b	13	24	pathway	pathway	NN
cord-252230-s1qd3x1b	13	25	,	,	,
cord-252230-s1qd3x1b	13	26	including	include	VBG
cord-252230-s1qd3x1b	13	27	the	the	DT
cord-252230-s1qd3x1b	13	28	formation	formation	NN
cord-252230-s1qd3x1b	13	29	of	of	IN
cord-252230-s1qd3x1b	13	30	autophagosomes	autophagosomes	NNP
cord-252230-s1qd3x1b	13	31	,	,	,
cord-252230-s1qd3x1b	13	32	double	double	JJ
cord-252230-s1qd3x1b	13	33	membrane	membrane	NN
cord-252230-s1qd3x1b	13	34	vesicles	vesicle	NNS
cord-252230-s1qd3x1b	13	35	that	that	WDT
cord-252230-s1qd3x1b	13	36	capture	capture	VBP
cord-252230-s1qd3x1b	13	37	cellular	cellular	JJ
cord-252230-s1qd3x1b	13	38	cargo	cargo	NN
cord-252230-s1qd3x1b	13	39	and	and	CC
cord-252230-s1qd3x1b	13	40	subsequently	subsequently	RB
cord-252230-s1qd3x1b	13	41	deliver	deliver	VB
cord-252230-s1qd3x1b	13	42	them	-PRON-	PRP
cord-252230-s1qd3x1b	13	43	to	to	IN
cord-252230-s1qd3x1b	13	44	the	the	DT
cord-252230-s1qd3x1b	13	45	lysosome	lysosome	NN
cord-252230-s1qd3x1b	13	46	for	for	IN
cord-252230-s1qd3x1b	13	47	degradation	degradation	NN
cord-252230-s1qd3x1b	13	48	(	(	-LRB-
cord-252230-s1qd3x1b	13	49	Tsukada	Tsukada	NNP
cord-252230-s1qd3x1b	13	50	and	and	CC
cord-252230-s1qd3x1b	13	51	Ohsumi	Ohsumi	NNP
cord-252230-s1qd3x1b	13	52	,	,	,
cord-252230-s1qd3x1b	13	53	1993	1993	CD
cord-252230-s1qd3x1b	13	54	;	;	:
cord-252230-s1qd3x1b	14	1	Thumm	Thumm	NNP
cord-252230-s1qd3x1b	14	2	et	et	NNP
cord-252230-s1qd3x1b	14	3	al	al	NNP
cord-252230-s1qd3x1b	14	4	.	.	.
cord-252230-s1qd3x1b	15	1	,	,	,
cord-252230-s1qd3x1b	15	2	1994	1994	CD
cord-252230-s1qd3x1b	15	3	;	;	:
cord-252230-s1qd3x1b	15	4	Harding	Harding	NNP
cord-252230-s1qd3x1b	15	5	et	et	NNP
cord-252230-s1qd3x1b	15	6	al	al	NNP
cord-252230-s1qd3x1b	15	7	.	.	NNP
cord-252230-s1qd3x1b	15	8	,	,	,
cord-252230-s1qd3x1b	15	9	1996	1996	CD
cord-252230-s1qd3x1b	15	10	)	)	-RRB-
cord-252230-s1qd3x1b	15	11	.	.	.
cord-252230-s1qd3x1b	16	1	Since	since	IN
cord-252230-s1qd3x1b	16	2	the	the	DT
cord-252230-s1qd3x1b	16	3	discovery	discovery	NN
cord-252230-s1qd3x1b	16	4	of	of	IN
cord-252230-s1qd3x1b	16	5	ATGs	atg	NNS
cord-252230-s1qd3x1b	16	6	,	,	,
cord-252230-s1qd3x1b	16	7	an	an	DT
cord-252230-s1qd3x1b	16	8	explosion	explosion	NN
cord-252230-s1qd3x1b	16	9	of	of	IN
cord-252230-s1qd3x1b	16	10	research	research	NN
cord-252230-s1qd3x1b	16	11	on	on	IN
cord-252230-s1qd3x1b	16	12	autophagy	autophagy	NN
cord-252230-s1qd3x1b	16	13	has	have	VBZ
cord-252230-s1qd3x1b	16	14	led	lead	VBN
cord-252230-s1qd3x1b	16	15	to	to	IN
cord-252230-s1qd3x1b	16	16	seminal	seminal	JJ
cord-252230-s1qd3x1b	16	17	advances	advance	NNS
cord-252230-s1qd3x1b	16	18	in	in	IN
cord-252230-s1qd3x1b	16	19	understanding	understand	VBG
cord-252230-s1qd3x1b	16	20	the	the	DT
cord-252230-s1qd3x1b	16	21	molecular	molecular	JJ
cord-252230-s1qd3x1b	16	22	regulation	regulation	NN
cord-252230-s1qd3x1b	16	23	of	of	IN
cord-252230-s1qd3x1b	16	24	the	the	DT
cord-252230-s1qd3x1b	16	25	autophagy	autophagy	NN
cord-252230-s1qd3x1b	16	26	trafficking	trafficking	NN
cord-252230-s1qd3x1b	16	27	process	process	NN
cord-252230-s1qd3x1b	16	28	,	,	,
cord-252230-s1qd3x1b	16	29	dissecting	dissect	VBG
cord-252230-s1qd3x1b	16	30	how	how	WRB
cord-252230-s1qd3x1b	16	31	autophagy	autophagy	NN
cord-252230-s1qd3x1b	16	32	controls	control	VBZ
cord-252230-s1qd3x1b	16	33	cell	cell	NN
cord-252230-s1qd3x1b	16	34	survival	survival	NN
cord-252230-s1qd3x1b	16	35	and	and	CC
cord-252230-s1qd3x1b	16	36	metabolic	metabolic	JJ
cord-252230-s1qd3x1b	16	37	fitness	fitness	NN
cord-252230-s1qd3x1b	16	38	in	in	IN
cord-252230-s1qd3x1b	16	39	response	response	NN
cord-252230-s1qd3x1b	16	40	to	to	IN
cord-252230-s1qd3x1b	16	41	countless	countless	JJ
cord-252230-s1qd3x1b	16	42	stressors	stressor	NNS
cord-252230-s1qd3x1b	16	43	,	,	,
cord-252230-s1qd3x1b	16	44	and	and	CC
cord-252230-s1qd3x1b	16	45	illuminating	illuminate	VBG
cord-252230-s1qd3x1b	16	46	the	the	DT
cord-252230-s1qd3x1b	16	47	diverse	diverse	JJ
cord-252230-s1qd3x1b	16	48	functions	function	NNS
cord-252230-s1qd3x1b	16	49	of	of	IN
cord-252230-s1qd3x1b	16	50	the	the	DT
cord-252230-s1qd3x1b	16	51	autophagy	autophagy	NN
cord-252230-s1qd3x1b	16	52	pathway	pathway	NN
cord-252230-s1qd3x1b	16	53	in	in	IN
cord-252230-s1qd3x1b	16	54	both	both	DT
cord-252230-s1qd3x1b	16	55	normal	normal	JJ
cord-252230-s1qd3x1b	16	56	physiology	physiology	NN
cord-252230-s1qd3x1b	16	57	and	and	CC
cord-252230-s1qd3x1b	16	58	disease	disease	NN
cord-252230-s1qd3x1b	17	1	(	(	-LRB-
cord-252230-s1qd3x1b	17	2	Choi	Choi	NNP
cord-252230-s1qd3x1b	17	3	et	et	NNP
cord-252230-s1qd3x1b	17	4	al	al	NNP
cord-252230-s1qd3x1b	17	5	.	.	NNP
cord-252230-s1qd3x1b	17	6	,	,	,
cord-252230-s1qd3x1b	17	7	2013	2013	CD
cord-252230-s1qd3x1b	17	8	;	;	:
cord-252230-s1qd3x1b	18	1	Kaur	Kaur	NNP
cord-252230-s1qd3x1b	18	2	and	and	CC
cord-252230-s1qd3x1b	18	3	Debnath	Debnath	NNP
cord-252230-s1qd3x1b	18	4	,	,	,
cord-252230-s1qd3x1b	18	5	2015	2015	CD
cord-252230-s1qd3x1b	18	6	)	)	-RRB-
cord-252230-s1qd3x1b	18	7	.	.	.
cord-252230-s1qd3x1b	19	1	At	at	IN
cord-252230-s1qd3x1b	19	2	the	the	DT
cord-252230-s1qd3x1b	19	3	same	same	JJ
cord-252230-s1qd3x1b	19	4	time	time	NN
cord-252230-s1qd3x1b	19	5	,	,	,
cord-252230-s1qd3x1b	19	6	we	-PRON-	PRP
cord-252230-s1qd3x1b	19	7	have	have	VBP
cord-252230-s1qd3x1b	19	8	begun	begin	VBN
cord-252230-s1qd3x1b	19	9	to	to	TO
cord-252230-s1qd3x1b	19	10	appreciate	appreciate	VB
cord-252230-s1qd3x1b	19	11	that	that	IN
cord-252230-s1qd3x1b	19	12	various	various	JJ
cord-252230-s1qd3x1b	19	13	ATGs	atg	NNS
cord-252230-s1qd3x1b	19	14	and	and	CC
cord-252230-s1qd3x1b	19	15	other	other	JJ
cord-252230-s1qd3x1b	19	16	autophagy	autophagy	NN
cord-252230-s1qd3x1b	19	17	regulators	regulator	NNS
cord-252230-s1qd3x1b	19	18	are	be	VBP
cord-252230-s1qd3x1b	19	19	deployed	deploy	VBN
cord-252230-s1qd3x1b	19	20	in	in	IN
cord-252230-s1qd3x1b	19	21	assorted	assorted	JJ
cord-252230-s1qd3x1b	19	22	fundamental	fundamental	JJ
cord-252230-s1qd3x1b	19	23	processes	process	NNS
cord-252230-s1qd3x1b	19	24	that	that	WDT
cord-252230-s1qd3x1b	19	25	are	be	VBP
cord-252230-s1qd3x1b	19	26	distinct	distinct	JJ
cord-252230-s1qd3x1b	19	27	and	and	CC
cord-252230-s1qd3x1b	19	28	separable	separable	JJ
cord-252230-s1qd3x1b	19	29	from	from	IN
cord-252230-s1qd3x1b	19	30	their	-PRON-	PRP$
cord-252230-s1qd3x1b	19	31	wellestablished	wellestablished	JJ
cord-252230-s1qd3x1b	19	32	roles	role	NNS
cord-252230-s1qd3x1b	19	33	in	in	IN
cord-252230-s1qd3x1b	19	34	mediating	mediate	VBG
cord-252230-s1qd3x1b	19	35	autodigestion	autodigestion	NN
cord-252230-s1qd3x1b	19	36	via	via	IN
cord-252230-s1qd3x1b	19	37	the	the	DT
cord-252230-s1qd3x1b	19	38	lysosome	lysosome	NN
cord-252230-s1qd3x1b	19	39	.	.	.
cord-252230-s1qd3x1b	20	1	This	this	DT
cord-252230-s1qd3x1b	20	2	review	review	NN
cord-252230-s1qd3x1b	20	3	highlights	highlight	VBZ
cord-252230-s1qd3x1b	20	4	this	this	DT
cord-252230-s1qd3x1b	20	5	exciting	exciting	JJ
cord-252230-s1qd3x1b	20	6	new	new	JJ
cord-252230-s1qd3x1b	20	7	facet	facet	NN
cord-252230-s1qd3x1b	20	8	of	of	IN
cord-252230-s1qd3x1b	20	9	autophagy	autophagy	NN
cord-252230-s1qd3x1b	20	10	research	research	NN
cord-252230-s1qd3x1b	20	11	and	and	CC
cord-252230-s1qd3x1b	20	12	summarizes	summarize	VBZ
cord-252230-s1qd3x1b	20	13	our	-PRON-	PRP$
cord-252230-s1qd3x1b	20	14	current	current	JJ
cord-252230-s1qd3x1b	20	15	understanding	understanding	NN
cord-252230-s1qd3x1b	20	16	of	of	IN
cord-252230-s1qd3x1b	20	17	these	these	DT
cord-252230-s1qd3x1b	20	18	autophagy	autophagy	NN
cord-252230-s1qd3x1b	20	19	-	-	HYPH
cord-252230-s1qd3x1b	20	20	related	relate	VBN
cord-252230-s1qd3x1b	20	21	functions	function	NNS
cord-252230-s1qd3x1b	20	22	and	and	CC
cord-252230-s1qd3x1b	20	23	signaling	signal	VBG
cord-252230-s1qd3x1b	20	24	pathways	pathway	NNS
cord-252230-s1qd3x1b	20	25	mediated	mediate	VBN
cord-252230-s1qd3x1b	20	26	by	by	IN
cord-252230-s1qd3x1b	20	27	individual	individual	JJ
cord-252230-s1qd3x1b	20	28	ATGs	atg	NNS
cord-252230-s1qd3x1b	20	29	as	as	RB
cord-252230-s1qd3x1b	20	30	well	well	RB
cord-252230-s1qd3x1b	20	31	as	as	IN
cord-252230-s1qd3x1b	20	32	entire	entire	JJ
cord-252230-s1qd3x1b	20	33	cell	cell	NN
cord-252230-s1qd3x1b	20	34	biological	biological	JJ
cord-252230-s1qd3x1b	20	35	subroutines	subroutine	NNS
cord-252230-s1qd3x1b	20	36	using	use	VBG
cord-252230-s1qd3x1b	20	37	multiple	multiple	JJ
cord-252230-s1qd3x1b	20	38	components	component	NNS
cord-252230-s1qd3x1b	20	39	of	of	IN
cord-252230-s1qd3x1b	20	40	the	the	DT
cord-252230-s1qd3x1b	20	41	autophagy	autophagy	NN
cord-252230-s1qd3x1b	20	42	machinery	machinery	NN
cord-252230-s1qd3x1b	20	43	.	.	.
cord-252230-s1qd3x1b	21	1	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	21	2	consists	consist	VBZ
cord-252230-s1qd3x1b	21	3	of	of	IN
cord-252230-s1qd3x1b	21	4	three	three	CD
cord-252230-s1qd3x1b	21	5	cellular	cellular	JJ
cord-252230-s1qd3x1b	21	6	self	self	NN
cord-252230-s1qd3x1b	21	7	-	-	HYPH
cord-252230-s1qd3x1b	21	8	eating	eat	VBG
cord-252230-s1qd3x1b	21	9	mechanisms	mechanism	NNS
cord-252230-s1qd3x1b	21	10	that	that	WDT
cord-252230-s1qd3x1b	21	11	converge	converge	VBP
cord-252230-s1qd3x1b	21	12	on	on	IN
cord-252230-s1qd3x1b	21	13	the	the	DT
cord-252230-s1qd3x1b	21	14	lysosome	lysosome	NN
cord-252230-s1qd3x1b	21	15	:	:	:
cord-252230-s1qd3x1b	21	16	microautophagy	microautophagy	NN
cord-252230-s1qd3x1b	21	17	,	,	,
cord-252230-s1qd3x1b	21	18	chaperonemediated	chaperonemediated	JJ
cord-252230-s1qd3x1b	21	19	autophagy	autophagy	NN
cord-252230-s1qd3x1b	21	20	,	,	,
cord-252230-s1qd3x1b	21	21	and	and	CC
cord-252230-s1qd3x1b	21	22	macroautophagy	macroautophagy	NNS
cord-252230-s1qd3x1b	21	23	.	.	.
cord-252230-s1qd3x1b	22	1	Among	among	IN
cord-252230-s1qd3x1b	22	2	these	these	DT
cord-252230-s1qd3x1b	22	3	,	,	,
cord-252230-s1qd3x1b	22	4	macroautophagy	macroautophagy	NNS
cord-252230-s1qd3x1b	22	5	(	(	-LRB-
cord-252230-s1qd3x1b	22	6	hereafter	hereafter	RB
cord-252230-s1qd3x1b	22	7	called	call	VBN
cord-252230-s1qd3x1b	22	8	autophagy	autophagy	NN
cord-252230-s1qd3x1b	22	9	)	)	-RRB-
cord-252230-s1qd3x1b	22	10	is	be	VBZ
cord-252230-s1qd3x1b	22	11	the	the	DT
cord-252230-s1qd3x1b	22	12	most	most	RBS
cord-252230-s1qd3x1b	22	13	well	well	RB
cord-252230-s1qd3x1b	22	14	studied	study	VBN
cord-252230-s1qd3x1b	22	15	and	and	CC
cord-252230-s1qd3x1b	22	16	genetically	genetically	RB
cord-252230-s1qd3x1b	22	17	controlled	control	VBN
cord-252230-s1qd3x1b	22	18	by	by	IN
cord-252230-s1qd3x1b	22	19	ATGs	atg	NNS
cord-252230-s1qd3x1b	22	20	.	.	.
cord-252230-s1qd3x1b	23	1	Classic	classic	JJ
cord-252230-s1qd3x1b	23	2	autophagy	autophagy	NN
cord-252230-s1qd3x1b	23	3	proceeds	proceed	VBZ
cord-252230-s1qd3x1b	23	4	through	through	IN
cord-252230-s1qd3x1b	23	5	multiple	multiple	JJ
cord-252230-s1qd3x1b	23	6	"	"	``
cord-252230-s1qd3x1b	23	7	canonical	canonical	JJ
cord-252230-s1qd3x1b	23	8	"	"	''
cord-252230-s1qd3x1b	23	9	steps	step	NNS
cord-252230-s1qd3x1b	23	10	that	that	WDT
cord-252230-s1qd3x1b	23	11	include	include	VBP
cord-252230-s1qd3x1b	23	12	(	(	-LRB-
cord-252230-s1qd3x1b	23	13	1	1	CD
cord-252230-s1qd3x1b	23	14	)	)	-RRB-
cord-252230-s1qd3x1b	23	15	initiation	initiation	NN
cord-252230-s1qd3x1b	23	16	by	by	IN
cord-252230-s1qd3x1b	23	17	an	an	DT
cord-252230-s1qd3x1b	23	18	autophagy	autophagy	NN
cord-252230-s1qd3x1b	23	19	-	-	HYPH
cord-252230-s1qd3x1b	23	20	inducing	induce	VBG
cord-252230-s1qd3x1b	23	21	signal	signal	NN
cord-252230-s1qd3x1b	23	22	,	,	,
cord-252230-s1qd3x1b	23	23	(	(	-LRB-
cord-252230-s1qd3x1b	23	24	2	2	LS
cord-252230-s1qd3x1b	23	25	)	)	-RRB-
cord-252230-s1qd3x1b	23	26	nucleation	nucleation	NN
cord-252230-s1qd3x1b	23	27	of	of	IN
cord-252230-s1qd3x1b	23	28	an	an	DT
cord-252230-s1qd3x1b	23	29	isolation	isolation	NN
cord-252230-s1qd3x1b	23	30	membrane	membrane	NN
cord-252230-s1qd3x1b	23	31	or	or	CC
cord-252230-s1qd3x1b	23	32	phagophore	phagophore	NN
cord-252230-s1qd3x1b	23	33	assembly	assembly	NN
cord-252230-s1qd3x1b	23	34	site	site	NN
cord-252230-s1qd3x1b	23	35	,	,	,
cord-252230-s1qd3x1b	23	36	(	(	-LRB-
cord-252230-s1qd3x1b	23	37	3	3	LS
cord-252230-s1qd3x1b	23	38	)	)	-RRB-
cord-252230-s1qd3x1b	23	39	elongation	elongation	NN
cord-252230-s1qd3x1b	23	40	and	and	CC
cord-252230-s1qd3x1b	23	41	sealing	sealing	NN
cord-252230-s1qd3x1b	23	42	of	of	IN
cord-252230-s1qd3x1b	23	43	this	this	DT
cord-252230-s1qd3x1b	23	44	double	double	JJ
cord-252230-s1qd3x1b	23	45	membrane	membrane	NN
cord-252230-s1qd3x1b	23	46	around	around	IN
cord-252230-s1qd3x1b	23	47	the	the	DT
cord-252230-s1qd3x1b	23	48	cargo	cargo	NN
cord-252230-s1qd3x1b	23	49	to	to	TO
cord-252230-s1qd3x1b	23	50	be	be	VB
cord-252230-s1qd3x1b	23	51	sequestered	sequester	VBN
cord-252230-s1qd3x1b	23	52	to	to	TO
cord-252230-s1qd3x1b	23	53	form	form	VB
cord-252230-s1qd3x1b	23	54	an	an	DT
cord-252230-s1qd3x1b	23	55	autophagosome	autophagosome	NN
cord-252230-s1qd3x1b	23	56	,	,	,
cord-252230-s1qd3x1b	23	57	(	(	-LRB-
cord-252230-s1qd3x1b	23	58	4	4	LS
cord-252230-s1qd3x1b	23	59	)	)	-RRB-
cord-252230-s1qd3x1b	23	60	docking	docking	NN
cord-252230-s1qd3x1b	23	61	and	and	CC
cord-252230-s1qd3x1b	23	62	fusion	fusion	NN
cord-252230-s1qd3x1b	23	63	of	of	IN
cord-252230-s1qd3x1b	23	64	the	the	DT
cord-252230-s1qd3x1b	23	65	autophagosome	autophagosome	NN
cord-252230-s1qd3x1b	23	66	with	with	IN
cord-252230-s1qd3x1b	23	67	the	the	DT
cord-252230-s1qd3x1b	23	68	lysosome	lysosome	NN
cord-252230-s1qd3x1b	23	69	to	to	TO
cord-252230-s1qd3x1b	23	70	form	form	VB
cord-252230-s1qd3x1b	23	71	an	an	DT
cord-252230-s1qd3x1b	23	72	autolysosome	autolysosome	NN
cord-252230-s1qd3x1b	23	73	,	,	,
cord-252230-s1qd3x1b	23	74	and	and	CC
cord-252230-s1qd3x1b	23	75	(	(	-LRB-
cord-252230-s1qd3x1b	23	76	5	5	LS
cord-252230-s1qd3x1b	23	77	)	)	-RRB-
cord-252230-s1qd3x1b	23	78	degradation	degradation	NN
cord-252230-s1qd3x1b	23	79	of	of	IN
cord-252230-s1qd3x1b	23	80	the	the	DT
cord-252230-s1qd3x1b	23	81	vesicle	vesicle	NN
cord-252230-s1qd3x1b	23	82	contents	content	NNS
cord-252230-s1qd3x1b	23	83	by	by	IN
cord-252230-s1qd3x1b	23	84	lysosomal	lysosomal	JJ
cord-252230-s1qd3x1b	23	85	enzymes	enzyme	NNS
cord-252230-s1qd3x1b	23	86	(	(	-LRB-
cord-252230-s1qd3x1b	23	87	Fig	fig	NN
cord-252230-s1qd3x1b	23	88	.	.	.
cord-252230-s1qd3x1b	23	89	1	1	CD
cord-252230-s1qd3x1b	23	90	A	a	CD
cord-252230-s1qd3x1b	23	91	)	)	-RRB-
cord-252230-s1qd3x1b	23	92	.	.	.
cord-252230-s1qd3x1b	24	1	Initiation	initiation	NN
cord-252230-s1qd3x1b	24	2	,	,	,
cord-252230-s1qd3x1b	24	3	nucleation	nucleation	NN
cord-252230-s1qd3x1b	24	4	,	,	,
cord-252230-s1qd3x1b	24	5	and	and	CC
cord-252230-s1qd3x1b	24	6	elongation	elongation	NN
cord-252230-s1qd3x1b	24	7	require	require	VBP
cord-252230-s1qd3x1b	24	8	the	the	DT
cord-252230-s1qd3x1b	24	9	hierarchical	hierarchical	JJ
cord-252230-s1qd3x1b	24	10	recruitment	recruitment	NN
cord-252230-s1qd3x1b	24	11	and	and	CC
cord-252230-s1qd3x1b	24	12	activity	activity	NN
cord-252230-s1qd3x1b	24	13	of	of	IN
cord-252230-s1qd3x1b	24	14	∼15	∼15	NNP
cord-252230-s1qd3x1b	24	15	ATGs	atg	NNS
cord-252230-s1qd3x1b	24	16	and	and	CC
cord-252230-s1qd3x1b	24	17	other	other	JJ
cord-252230-s1qd3x1b	24	18	proteins	protein	NNS
cord-252230-s1qd3x1b	24	19	to	to	IN
cord-252230-s1qd3x1b	24	20	the	the	DT
cord-252230-s1qd3x1b	24	21	phagophore	phagophore	NNP
cord-252230-s1qd3x1b	24	22	assembly	assembly	NNP
cord-252230-s1qd3x1b	24	23	site	site	NN
cord-252230-s1qd3x1b	24	24	to	to	TO
cord-252230-s1qd3x1b	24	25	construct	construct	VB
cord-252230-s1qd3x1b	24	26	the	the	DT
cord-252230-s1qd3x1b	24	27	autophagosome	autophagosome	NN
cord-252230-s1qd3x1b	24	28	(	(	-LRB-
cord-252230-s1qd3x1b	24	29	Codogno	Codogno	NNP
cord-252230-s1qd3x1b	24	30	et	et	NNP
cord-252230-s1qd3x1b	24	31	al	al	NNP
cord-252230-s1qd3x1b	24	32	.	.	NNP
cord-252230-s1qd3x1b	24	33	,	,	,
cord-252230-s1qd3x1b	24	34	2011	2011	CD
cord-252230-s1qd3x1b	24	35	;	;	:
cord-252230-s1qd3x1b	24	36	Mizushima	Mizushima	NNP
cord-252230-s1qd3x1b	24	37	et	et	FW
cord-252230-s1qd3x1b	24	38	al	al	NNP
cord-252230-s1qd3x1b	24	39	.	.	NNP
cord-252230-s1qd3x1b	24	40	,	,	,
cord-252230-s1qd3x1b	24	41	2011	2011	CD
cord-252230-s1qd3x1b	24	42	)	)	-RRB-
cord-252230-s1qd3x1b	24	43	.	.	.
cord-252230-s1qd3x1b	25	1	In	in	IN
cord-252230-s1qd3x1b	25	2	this	this	DT
cord-252230-s1qd3x1b	25	3	context	context	NN
cord-252230-s1qd3x1b	25	4	,	,	,
cord-252230-s1qd3x1b	25	5	the	the	DT
cord-252230-s1qd3x1b	25	6	term	term	NN
cord-252230-s1qd3x1b	25	7	"	"	``
cord-252230-s1qd3x1b	25	8	noncanonical	noncanonical	JJ
cord-252230-s1qd3x1b	25	9	autophagy	autophagy	NN
cord-252230-s1qd3x1b	25	10	"	"	''
cord-252230-s1qd3x1b	25	11	refers	refer	VBZ
cord-252230-s1qd3x1b	25	12	to	to	IN
cord-252230-s1qd3x1b	25	13	the	the	DT
cord-252230-s1qd3x1b	25	14	formation	formation	NN
cord-252230-s1qd3x1b	25	15	of	of	IN
cord-252230-s1qd3x1b	25	16	classic	classic	JJ
cord-252230-s1qd3x1b	25	17	double	double	JJ
cord-252230-s1qd3x1b	25	18	membrane	membrane	NN
cord-252230-s1qd3x1b	25	19	autophagosomes	autophagosome	NNS
cord-252230-s1qd3x1b	25	20	that	that	WDT
cord-252230-s1qd3x1b	25	21	does	do	VBZ
cord-252230-s1qd3x1b	25	22	not	not	RB
cord-252230-s1qd3x1b	25	23	require	require	VB
cord-252230-s1qd3x1b	25	24	the	the	DT
cord-252230-s1qd3x1b	25	25	activity	activity	NN
cord-252230-s1qd3x1b	25	26	of	of	IN
cord-252230-s1qd3x1b	25	27	one	one	CD
cord-252230-s1qd3x1b	25	28	or	or	CC
cord-252230-s1qd3x1b	25	29	more	more	JJR
cord-252230-s1qd3x1b	25	30	key	key	JJ
cord-252230-s1qd3x1b	25	31	ATGs	atg	NNS
cord-252230-s1qd3x1b	25	32	.	.	.
cord-252230-s1qd3x1b	26	1	Nonetheless	nonetheless	RB
cord-252230-s1qd3x1b	26	2	,	,	,
cord-252230-s1qd3x1b	26	3	both	both	CC
cord-252230-s1qd3x1b	26	4	canonical	canonical	JJ
cord-252230-s1qd3x1b	26	5	and	and	CC
cord-252230-s1qd3x1b	26	6	noncanonical	noncanonical	JJ
cord-252230-s1qd3x1b	26	7	autophagy	autophagy	NN
cord-252230-s1qd3x1b	26	8	are	be	VBP
cord-252230-s1qd3x1b	26	9	fundamentally	fundamentally	RB
cord-252230-s1qd3x1b	26	10	autodigestive	autodigestive	JJ
cord-252230-s1qd3x1b	26	11	pathways	pathway	NNS
cord-252230-s1qd3x1b	26	12	requiring	require	VBG
cord-252230-s1qd3x1b	26	13	autophagosome	autophagosome	JJ
cord-252230-s1qd3x1b	26	14	formation	formation	NN
cord-252230-s1qd3x1b	26	15	,	,	,
cord-252230-s1qd3x1b	26	16	followed	follow	VBN
cord-252230-s1qd3x1b	26	17	by	by	IN
cord-252230-s1qd3x1b	26	18	fusion	fusion	NN
cord-252230-s1qd3x1b	26	19	with	with	IN
cord-252230-s1qd3x1b	26	20	the	the	DT
cord-252230-s1qd3x1b	26	21	lysosome	lysosome	NN
cord-252230-s1qd3x1b	27	1	(	(	-LRB-
cord-252230-s1qd3x1b	27	2	Codogno	Codogno	NNP
cord-252230-s1qd3x1b	27	3	et	et	NNP
cord-252230-s1qd3x1b	27	4	al	al	NNP
cord-252230-s1qd3x1b	27	5	.	.	NNP
cord-252230-s1qd3x1b	27	6	,	,	,
cord-252230-s1qd3x1b	27	7	2011	2011	CD
cord-252230-s1qd3x1b	27	8	)	)	-RRB-
cord-252230-s1qd3x1b	27	9	.	.	.
cord-252230-s1qd3x1b	28	1	Adding	add	VBG
cord-252230-s1qd3x1b	28	2	to	to	IN
cord-252230-s1qd3x1b	28	3	this	this	DT
cord-252230-s1qd3x1b	28	4	complexity	complexity	NN
cord-252230-s1qd3x1b	28	5	,	,	,
cord-252230-s1qd3x1b	28	6	ATG	ATG	NNP
cord-252230-s1qd3x1b	28	7	proteins	protein	NNS
cord-252230-s1qd3x1b	28	8	,	,	,
cord-252230-s1qd3x1b	28	9	both	both	CC
cord-252230-s1qd3x1b	28	10	individually	individually	RB
cord-252230-s1qd3x1b	28	11	and	and	CC
cord-252230-s1qd3x1b	28	12	as	as	IN
cord-252230-s1qd3x1b	28	13	part	part	NN
cord-252230-s1qd3x1b	28	14	of	of	IN
cord-252230-s1qd3x1b	28	15	larger	large	JJR
cord-252230-s1qd3x1b	28	16	networks	network	NNS
cord-252230-s1qd3x1b	28	17	,	,	,
cord-252230-s1qd3x1b	28	18	control	control	VB
cord-252230-s1qd3x1b	28	19	pathways	pathway	NNS
cord-252230-s1qd3x1b	28	20	that	that	WDT
cord-252230-s1qd3x1b	28	21	either	either	CC
cord-252230-s1qd3x1b	28	22	do	do	VBP
cord-252230-s1qd3x1b	28	23	not	not	RB
cord-252230-s1qd3x1b	28	24	involve	involve	VB
cord-252230-s1qd3x1b	28	25	the	the	DT
cord-252230-s1qd3x1b	28	26	formation	formation	NN
cord-252230-s1qd3x1b	28	27	of	of	IN
cord-252230-s1qd3x1b	28	28	a	a	DT
cord-252230-s1qd3x1b	28	29	classic	classic	JJ
cord-252230-s1qd3x1b	28	30	autophagosome	autophagosome	NN
cord-252230-s1qd3x1b	28	31	or	or	CC
cord-252230-s1qd3x1b	28	32	do	do	VBP
cord-252230-s1qd3x1b	28	33	not	not	RB
cord-252230-s1qd3x1b	28	34	terminate	terminate	VB
cord-252230-s1qd3x1b	28	35	in	in	IN
cord-252230-s1qd3x1b	28	36	lysosomal	lysosomal	JJ
cord-252230-s1qd3x1b	28	37	degradation	degradation	NN
cord-252230-s1qd3x1b	28	38	and	and	CC
cord-252230-s1qd3x1b	28	39	nutrient	nutrient	NN
cord-252230-s1qd3x1b	28	40	recycling	recycling	NN
cord-252230-s1qd3x1b	28	41	(	(	-LRB-
cord-252230-s1qd3x1b	28	42	Subramani	Subramani	NNP
cord-252230-s1qd3x1b	28	43	and	and	CC
cord-252230-s1qd3x1b	28	44	Malhotra	Malhotra	NNP
cord-252230-s1qd3x1b	28	45	,	,	,
cord-252230-s1qd3x1b	28	46	2013	2013	CD
cord-252230-s1qd3x1b	28	47	)	)	-RRB-
cord-252230-s1qd3x1b	28	48	.	.	.
cord-252230-s1qd3x1b	29	1	Although	although	IN
cord-252230-s1qd3x1b	29	2	not	not	RB
cord-252230-s1qd3x1b	29	3	inclusive	inclusive	JJ
cord-252230-s1qd3x1b	29	4	,	,	,
cord-252230-s1qd3x1b	29	5	the	the	DT
cord-252230-s1qd3x1b	29	6	list	list	NN
cord-252230-s1qd3x1b	29	7	of	of	IN
cord-252230-s1qd3x1b	29	8	autophagy	autophagy	NN
cord-252230-s1qd3x1b	29	9	-	-	HYPH
cord-252230-s1qd3x1b	29	10	related	relate	VBN
cord-252230-s1qd3x1b	29	11	processes	process	NNS
cord-252230-s1qd3x1b	29	12	includes	include	VBZ
cord-252230-s1qd3x1b	29	13	secretion	secretion	NN
cord-252230-s1qd3x1b	29	14	and	and	CC
cord-252230-s1qd3x1b	29	15	exocytosis	exocytosis	NN
cord-252230-s1qd3x1b	29	16	,	,	,
cord-252230-s1qd3x1b	29	17	LC3-associated	lc3-associated	JJ
cord-252230-s1qd3x1b	29	18	phagocytosis	phagocytosis	NN
cord-252230-s1qd3x1b	29	19	(	(	-LRB-
cord-252230-s1qd3x1b	29	20	LAP	LAP	NNP
cord-252230-s1qd3x1b	29	21	)	)	-RRB-
cord-252230-s1qd3x1b	29	22	,	,	,
cord-252230-s1qd3x1b	29	23	viral	viral	JJ
cord-252230-s1qd3x1b	29	24	replication	replication	NN
cord-252230-s1qd3x1b	30	1	The	the	DT
cord-252230-s1qd3x1b	30	2	identification	identification	NN
cord-252230-s1qd3x1b	30	3	of	of	IN
cord-252230-s1qd3x1b	30	4	conserved	conserved	JJ
cord-252230-s1qd3x1b	30	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	30	6	-	-	HYPH
cord-252230-s1qd3x1b	30	7	related	relate	VBN
cord-252230-s1qd3x1b	30	8	proteins	protein	NNS
cord-252230-s1qd3x1b	30	9	(	(	-LRB-
cord-252230-s1qd3x1b	30	10	ATGs	atg	NNS
cord-252230-s1qd3x1b	30	11	)	)	-RRB-
cord-252230-s1qd3x1b	30	12	that	that	WDT
cord-252230-s1qd3x1b	30	13	mediate	mediate	VBP
cord-252230-s1qd3x1b	30	14	bulk	bulk	JJ
cord-252230-s1qd3x1b	30	15	degradation	degradation	NN
cord-252230-s1qd3x1b	30	16	of	of	IN
cord-252230-s1qd3x1b	30	17	cytosolic	cytosolic	JJ
cord-252230-s1qd3x1b	30	18	material	material	NN
cord-252230-s1qd3x1b	30	19	laid	lay	VBD
cord-252230-s1qd3x1b	30	20	the	the	DT
cord-252230-s1qd3x1b	30	21	foundation	foundation	NN
cord-252230-s1qd3x1b	30	22	for	for	IN
cord-252230-s1qd3x1b	30	23	breakthroughs	breakthrough	NNS
cord-252230-s1qd3x1b	30	24	linking	link	VBG
cord-252230-s1qd3x1b	30	25	autophagy	autophagy	NN
cord-252230-s1qd3x1b	30	26	to	to	IN
cord-252230-s1qd3x1b	30	27	a	a	DT
cord-252230-s1qd3x1b	30	28	litany	litany	JJ
cord-252230-s1qd3x1b	30	29	of	of	IN
cord-252230-s1qd3x1b	30	30	physiological	physiological	JJ
cord-252230-s1qd3x1b	30	31	processes	process	NNS
cord-252230-s1qd3x1b	30	32	and	and	CC
cord-252230-s1qd3x1b	30	33	disease	disease	NN
cord-252230-s1qd3x1b	30	34	conditions	condition	NNS
cord-252230-s1qd3x1b	30	35	.	.	.
cord-252230-s1qd3x1b	31	1	Recent	recent	JJ
cord-252230-s1qd3x1b	31	2	discoveries	discovery	NNS
cord-252230-s1qd3x1b	31	3	are	be	VBP
cord-252230-s1qd3x1b	31	4	revealing	reveal	VBG
cord-252230-s1qd3x1b	31	5	that	that	IN
cord-252230-s1qd3x1b	31	6	these	these	DT
cord-252230-s1qd3x1b	31	7	same	same	JJ
cord-252230-s1qd3x1b	31	8	ATGs	atg	NNS
cord-252230-s1qd3x1b	31	9	orchestrate	orchestrate	VBP
cord-252230-s1qd3x1b	31	10	processes	process	NNS
cord-252230-s1qd3x1b	31	11	that	that	WDT
cord-252230-s1qd3x1b	31	12	are	be	VBP
cord-252230-s1qd3x1b	31	13	related	relate	VBN
cord-252230-s1qd3x1b	31	14	to	to	IN
cord-252230-s1qd3x1b	31	15	,	,	,
cord-252230-s1qd3x1b	31	16	and	and	CC
cord-252230-s1qd3x1b	31	17	yet	yet	CC
cord-252230-s1qd3x1b	31	18	clearly	clearly	RB
cord-252230-s1qd3x1b	31	19	distinct	distinct	JJ
cord-252230-s1qd3x1b	31	20	from	from	IN
cord-252230-s1qd3x1b	31	21	,	,	,
cord-252230-s1qd3x1b	31	22	classic	classic	JJ
cord-252230-s1qd3x1b	31	23	autophagy	autophagy	NN
cord-252230-s1qd3x1b	31	24	.	.	.
cord-252230-s1qd3x1b	32	1	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	32	2	-	-	HYPH
cord-252230-s1qd3x1b	32	3	related	relate	VBN
cord-252230-s1qd3x1b	32	4	functions	function	NNS
cord-252230-s1qd3x1b	32	5	include	include	VBP
cord-252230-s1qd3x1b	32	6	secretion	secretion	NN
cord-252230-s1qd3x1b	32	7	,	,	,
cord-252230-s1qd3x1b	32	8	trafficking	trafficking	NN
cord-252230-s1qd3x1b	32	9	of	of	IN
cord-252230-s1qd3x1b	32	10	phagocytosed	phagocytosed	JJ
cord-252230-s1qd3x1b	32	11	material	material	NN
cord-252230-s1qd3x1b	32	12	,	,	,
cord-252230-s1qd3x1b	32	13	replication	replication	NN
cord-252230-s1qd3x1b	32	14	and	and	CC
cord-252230-s1qd3x1b	32	15	egress	egress	NN
cord-252230-s1qd3x1b	32	16	of	of	IN
cord-252230-s1qd3x1b	32	17	viral	viral	JJ
cord-252230-s1qd3x1b	32	18	particles	particle	NNS
cord-252230-s1qd3x1b	32	19	,	,	,
cord-252230-s1qd3x1b	32	20	and	and	CC
cord-252230-s1qd3x1b	32	21	regulation	regulation	NN
cord-252230-s1qd3x1b	32	22	of	of	IN
cord-252230-s1qd3x1b	32	23	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	32	24	and	and	CC
cord-252230-s1qd3x1b	32	25	immune	immune	JJ
cord-252230-s1qd3x1b	32	26	signaling	signaling	NN
cord-252230-s1qd3x1b	32	27	cascades	cascade	NNS
cord-252230-s1qd3x1b	32	28	.	.	.
cord-252230-s1qd3x1b	33	1	Here	here	RB
cord-252230-s1qd3x1b	33	2	,	,	,
cord-252230-s1qd3x1b	33	3	we	-PRON-	PRP
cord-252230-s1qd3x1b	33	4	define	define	VBP
cord-252230-s1qd3x1b	33	5	common	common	JJ
cord-252230-s1qd3x1b	33	6	processes	process	NNS
cord-252230-s1qd3x1b	33	7	dependent	dependent	JJ
cord-252230-s1qd3x1b	33	8	on	on	IN
cord-252230-s1qd3x1b	33	9	ATGs	atg	NNS
cord-252230-s1qd3x1b	33	10	,	,	,
cord-252230-s1qd3x1b	33	11	and	and	CC
cord-252230-s1qd3x1b	33	12	discuss	discuss	VB
cord-252230-s1qd3x1b	33	13	the	the	DT
cord-252230-s1qd3x1b	33	14	challenges	challenge	NNS
cord-252230-s1qd3x1b	33	15	in	in	IN
cord-252230-s1qd3x1b	33	16	mechanistically	mechanistically	RB
cord-252230-s1qd3x1b	33	17	separating	separate	VBG
cord-252230-s1qd3x1b	33	18	autophagy	autophagy	NN
cord-252230-s1qd3x1b	33	19	from	from	IN
cord-252230-s1qd3x1b	33	20	these	these	DT
cord-252230-s1qd3x1b	33	21	related	related	JJ
cord-252230-s1qd3x1b	33	22	pathways	pathway	NNS
cord-252230-s1qd3x1b	33	23	.	.	.
cord-252230-s1qd3x1b	34	1	Elucidating	elucidate	VBG
cord-252230-s1qd3x1b	34	2	the	the	DT
cord-252230-s1qd3x1b	34	3	molecular	molecular	JJ
cord-252230-s1qd3x1b	34	4	events	event	NNS
cord-252230-s1qd3x1b	34	5	that	that	WDT
cord-252230-s1qd3x1b	34	6	distinguish	distinguish	VBP
cord-252230-s1qd3x1b	34	7	how	how	WRB
cord-252230-s1qd3x1b	34	8	individual	individual	JJ
cord-252230-s1qd3x1b	34	9	ATGs	atg	NNS
cord-252230-s1qd3x1b	34	10	function	function	NN
cord-252230-s1qd3x1b	34	11	promises	promise	NNS
cord-252230-s1qd3x1b	34	12	to	to	TO
cord-252230-s1qd3x1b	34	13	improve	improve	VB
cord-252230-s1qd3x1b	34	14	our	-PRON-	PRP$
cord-252230-s1qd3x1b	34	15	understanding	understanding	NN
cord-252230-s1qd3x1b	34	16	of	of	IN
cord-252230-s1qd3x1b	34	17	the	the	DT
cord-252230-s1qd3x1b	34	18	origin	origin	NN
cord-252230-s1qd3x1b	34	19	of	of	IN
cord-252230-s1qd3x1b	34	20	diseases	disease	NNS
cord-252230-s1qd3x1b	34	21	ranging	range	VBG
cord-252230-s1qd3x1b	34	22	from	from	IN
cord-252230-s1qd3x1b	34	23	autoimmunity	autoimmunity	NN
cord-252230-s1qd3x1b	34	24	to	to	IN
cord-252230-s1qd3x1b	34	25	cancer	cancer	NN
cord-252230-s1qd3x1b	34	26	.	.	.
cord-252230-s1qd3x1b	35	1	and	and	CC
cord-252230-s1qd3x1b	35	2	exit	exit	NN
cord-252230-s1qd3x1b	35	3	,	,	,
cord-252230-s1qd3x1b	35	4	antigen	antigen	NN
cord-252230-s1qd3x1b	35	5	presentation	presentation	NN
cord-252230-s1qd3x1b	35	6	,	,	,
cord-252230-s1qd3x1b	35	7	and	and	CC
cord-252230-s1qd3x1b	35	8	ATG	ATG	NNP
cord-252230-s1qd3x1b	35	9	-	-	HYPH
cord-252230-s1qd3x1b	35	10	mediated	mediate	VBN
cord-252230-s1qd3x1b	35	11	regulation	regulation	NN
cord-252230-s1qd3x1b	35	12	of	of	IN
cord-252230-s1qd3x1b	35	13	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	35	14	and	and	CC
cord-252230-s1qd3x1b	35	15	immune	immune	JJ
cord-252230-s1qd3x1b	35	16	signaling	signaling	NN
cord-252230-s1qd3x1b	35	17	.	.	.
cord-252230-s1qd3x1b	36	1	Importantly	importantly	RB
cord-252230-s1qd3x1b	36	2	,	,	,
cord-252230-s1qd3x1b	36	3	these	these	DT
cord-252230-s1qd3x1b	36	4	processes	process	NNS
cord-252230-s1qd3x1b	36	5	are	be	VBP
cord-252230-s1qd3x1b	36	6	fundamentally	fundamentally	RB
cord-252230-s1qd3x1b	36	7	distinct	distinct	JJ
cord-252230-s1qd3x1b	36	8	from	from	IN
cord-252230-s1qd3x1b	36	9	classic	classic	JJ
cord-252230-s1qd3x1b	36	10	autophagy	autophagy	NN
cord-252230-s1qd3x1b	36	11	,	,	,
cord-252230-s1qd3x1b	36	12	and	and	CC
cord-252230-s1qd3x1b	36	13	certainly	certainly	RB
cord-252230-s1qd3x1b	36	14	,	,	,
cord-252230-s1qd3x1b	36	15	many	many	JJ
cord-252230-s1qd3x1b	36	16	can	can	MD
cord-252230-s1qd3x1b	36	17	be	be	VB
cord-252230-s1qd3x1b	36	18	construed	construe	VBN
cord-252230-s1qd3x1b	36	19	as	as	IN
cord-252230-s1qd3x1b	36	20	"	"	``
cord-252230-s1qd3x1b	36	21	noncanonical	noncanonical	JJ
cord-252230-s1qd3x1b	36	22	"	"	''
cord-252230-s1qd3x1b	36	23	functions	function	NNS
cord-252230-s1qd3x1b	36	24	for	for	IN
cord-252230-s1qd3x1b	36	25	the	the	DT
cord-252230-s1qd3x1b	36	26	individual	individual	JJ
cord-252230-s1qd3x1b	36	27	ATG	ATG	NNP
cord-252230-s1qd3x1b	36	28	proteins	protein	NNS
cord-252230-s1qd3x1b	36	29	that	that	WDT
cord-252230-s1qd3x1b	36	30	are	be	VBP
cord-252230-s1qd3x1b	36	31	involved	involve	VBN
cord-252230-s1qd3x1b	36	32	.	.	.
cord-252230-s1qd3x1b	37	1	However	however	RB
cord-252230-s1qd3x1b	37	2	,	,	,
cord-252230-s1qd3x1b	37	3	they	-PRON-	PRP
cord-252230-s1qd3x1b	37	4	are	be	VBP
cord-252230-s1qd3x1b	37	5	not	not	RB
cord-252230-s1qd3x1b	37	6	by	by	IN
cord-252230-s1qd3x1b	37	7	definition	definition	NN
cord-252230-s1qd3x1b	37	8	"	"	``
cord-252230-s1qd3x1b	37	9	noncanonical	noncanonical	JJ
cord-252230-s1qd3x1b	37	10	autophagy	autophagy	NN
cord-252230-s1qd3x1b	37	11	"	"	''
cord-252230-s1qd3x1b	37	12	in	in	IN
cord-252230-s1qd3x1b	37	13	its	-PRON-	PRP$
cord-252230-s1qd3x1b	37	14	strictest	strict	JJS
cord-252230-s1qd3x1b	37	15	sense	sense	NN
cord-252230-s1qd3x1b	37	16	.	.	.
cord-252230-s1qd3x1b	38	1	Hence	hence	RB
cord-252230-s1qd3x1b	38	2	,	,	,
cord-252230-s1qd3x1b	38	3	to	to	TO
cord-252230-s1qd3x1b	38	4	avoid	avoid	VB
cord-252230-s1qd3x1b	38	5	confusion	confusion	NN
cord-252230-s1qd3x1b	38	6	,	,	,
cord-252230-s1qd3x1b	38	7	the	the	DT
cord-252230-s1qd3x1b	38	8	term	term	NN
cord-252230-s1qd3x1b	38	9	"	"	``
cord-252230-s1qd3x1b	38	10	noncanonical	noncanonical	JJ
cord-252230-s1qd3x1b	38	11	"	"	''
cord-252230-s1qd3x1b	38	12	should	should	MD
cord-252230-s1qd3x1b	38	13	be	be	VB
cord-252230-s1qd3x1b	38	14	avoided	avoid	VBN
cord-252230-s1qd3x1b	38	15	when	when	WRB
cord-252230-s1qd3x1b	38	16	referring	refer	VBG
cord-252230-s1qd3x1b	38	17	to	to	IN
cord-252230-s1qd3x1b	38	18	these	these	DT
cord-252230-s1qd3x1b	38	19	autophagy	autophagy	NN
cord-252230-s1qd3x1b	38	20	-	-	HYPH
cord-252230-s1qd3x1b	38	21	related	relate	VBN
cord-252230-s1qd3x1b	38	22	processes	process	NNS
cord-252230-s1qd3x1b	38	23	.	.	.
cord-252230-s1qd3x1b	39	1	In	in	IN
cord-252230-s1qd3x1b	39	2	the	the	DT
cord-252230-s1qd3x1b	39	3	following	following	JJ
cord-252230-s1qd3x1b	39	4	sections	section	NNS
cord-252230-s1qd3x1b	39	5	,	,	,
cord-252230-s1qd3x1b	39	6	we	-PRON-	PRP
cord-252230-s1qd3x1b	39	7	overview	overview	VBP
cord-252230-s1qd3x1b	39	8	our	-PRON-	PRP$
cord-252230-s1qd3x1b	39	9	current	current	JJ
cord-252230-s1qd3x1b	39	10	understanding	understanding	NN
cord-252230-s1qd3x1b	39	11	of	of	IN
cord-252230-s1qd3x1b	39	12	this	this	DT
cord-252230-s1qd3x1b	39	13	diverse	diverse	JJ
cord-252230-s1qd3x1b	39	14	collection	collection	NN
cord-252230-s1qd3x1b	39	15	of	of	IN
cord-252230-s1qd3x1b	39	16	autophagy	autophagy	NN
cord-252230-s1qd3x1b	39	17	-	-	HYPH
cord-252230-s1qd3x1b	39	18	related	relate	VBN
cord-252230-s1qd3x1b	39	19	processes	process	NNS
cord-252230-s1qd3x1b	39	20	that	that	WDT
cord-252230-s1qd3x1b	39	21	are	be	VBP
cord-252230-s1qd3x1b	39	22	distinct	distinct	JJ
cord-252230-s1qd3x1b	39	23	from	from	IN
cord-252230-s1qd3x1b	39	24	classic	classic	JJ
cord-252230-s1qd3x1b	39	25	autophagy	autophagy	NN
cord-252230-s1qd3x1b	39	26	.	.	.
cord-252230-s1qd3x1b	40	1	In	in	IN
cord-252230-s1qd3x1b	40	2	addition	addition	NN
cord-252230-s1qd3x1b	40	3	to	to	IN
cord-252230-s1qd3x1b	40	4	its	-PRON-	PRP$
cord-252230-s1qd3x1b	40	5	established	establish	VBN
cord-252230-s1qd3x1b	40	6	role	role	NN
cord-252230-s1qd3x1b	40	7	in	in	IN
cord-252230-s1qd3x1b	40	8	lysosomal	lysosomal	JJ
cord-252230-s1qd3x1b	40	9	degradation	degradation	NN
cord-252230-s1qd3x1b	40	10	,	,	,
cord-252230-s1qd3x1b	40	11	the	the	DT
cord-252230-s1qd3x1b	40	12	autophagy	autophagy	NN
cord-252230-s1qd3x1b	40	13	machinery	machinery	NN
cord-252230-s1qd3x1b	40	14	controls	control	VBZ
cord-252230-s1qd3x1b	40	15	extracellular	extracellular	JJ
cord-252230-s1qd3x1b	40	16	secretion	secretion	NN
cord-252230-s1qd3x1b	40	17	.	.	.
cord-252230-s1qd3x1b	41	1	Evidence	evidence	NN
cord-252230-s1qd3x1b	41	2	to	to	IN
cord-252230-s1qd3x1b	41	3	date	date	NN
cord-252230-s1qd3x1b	41	4	most	most	RBS
cord-252230-s1qd3x1b	41	5	notably	notably	RB
cord-252230-s1qd3x1b	41	6	implicates	implicate	VBZ
cord-252230-s1qd3x1b	41	7	ATGs	atg	NNS
cord-252230-s1qd3x1b	41	8	in	in	IN
cord-252230-s1qd3x1b	41	9	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	41	10	secretion	secretion	NN
cord-252230-s1qd3x1b	41	11	of	of	IN
cord-252230-s1qd3x1b	41	12	proteins	protein	NNS
cord-252230-s1qd3x1b	41	13	lacking	lack	VBG
cord-252230-s1qd3x1b	41	14	an	an	DT
cord-252230-s1qd3x1b	41	15	N	n	CD
cord-252230-s1qd3x1b	41	16	-	-	HYPH
cord-252230-s1qd3x1b	41	17	terminal	terminal	JJ
cord-252230-s1qd3x1b	41	18	signal	signal	NN
cord-252230-s1qd3x1b	41	19	sequence	sequence	NN
cord-252230-s1qd3x1b	41	20	(	(	-LRB-
cord-252230-s1qd3x1b	41	21	Dupont	Dupont	NNP
cord-252230-s1qd3x1b	41	22	et	et	NNP
cord-252230-s1qd3x1b	41	23	al	al	NNP
cord-252230-s1qd3x1b	41	24	.	.	NNP
cord-252230-s1qd3x1b	41	25	,	,	,
cord-252230-s1qd3x1b	41	26	2011	2011	CD
cord-252230-s1qd3x1b	41	27	;	;	:
cord-252230-s1qd3x1b	42	1	Deretic	Deretic	NNP
cord-252230-s1qd3x1b	42	2	et	et	FW
cord-252230-s1qd3x1b	42	3	al	al	NNP
cord-252230-s1qd3x1b	42	4	.	.	NNP
cord-252230-s1qd3x1b	42	5	,	,	,
cord-252230-s1qd3x1b	42	6	2012	2012	CD
cord-252230-s1qd3x1b	42	7	;	;	:
cord-252230-s1qd3x1b	42	8	Malhotra	Malhotra	NNP
cord-252230-s1qd3x1b	42	9	,	,	,
cord-252230-s1qd3x1b	42	10	2013	2013	CD
cord-252230-s1qd3x1b	42	11	;	;	:
cord-252230-s1qd3x1b	42	12	Subramani	Subramani	NNP
cord-252230-s1qd3x1b	42	13	and	and	CC
cord-252230-s1qd3x1b	42	14	Malhotra	Malhotra	NNP
cord-252230-s1qd3x1b	42	15	,	,	,
cord-252230-s1qd3x1b	42	16	2013	2013	CD
cord-252230-s1qd3x1b	42	17	)	)	-RRB-
cord-252230-s1qd3x1b	42	18	.	.	.
cord-252230-s1qd3x1b	43	1	Whereas	whereas	IN
cord-252230-s1qd3x1b	43	2	the	the	DT
cord-252230-s1qd3x1b	43	3	majority	majority	NN
cord-252230-s1qd3x1b	43	4	of	of	IN
cord-252230-s1qd3x1b	43	5	eukaryotic	eukaryotic	JJ
cord-252230-s1qd3x1b	43	6	secretory	secretory	NN
cord-252230-s1qd3x1b	43	7	proteins	protein	NNS
cord-252230-s1qd3x1b	43	8	classically	classically	RB
cord-252230-s1qd3x1b	43	9	transit	transit	JJ
cord-252230-s1qd3x1b	43	10	to	to	IN
cord-252230-s1qd3x1b	43	11	the	the	DT
cord-252230-s1qd3x1b	43	12	surface	surface	NN
cord-252230-s1qd3x1b	43	13	via	via	IN
cord-252230-s1qd3x1b	43	14	the	the	DT
cord-252230-s1qd3x1b	43	15	ER	ER	NNP
cord-252230-s1qd3x1b	43	16	and	and	CC
cord-252230-s1qd3x1b	43	17	Golgi	Golgi	NNP
cord-252230-s1qd3x1b	43	18	apparatus	apparatus	NN
cord-252230-s1qd3x1b	43	19	,	,	,
cord-252230-s1qd3x1b	43	20	a	a	DT
cord-252230-s1qd3x1b	43	21	growing	grow	VBG
cord-252230-s1qd3x1b	43	22	list	list	NN
cord-252230-s1qd3x1b	43	23	of	of	IN
cord-252230-s1qd3x1b	43	24	proteins	protein	NNS
cord-252230-s1qd3x1b	43	25	traffic	traffic	NN
cord-252230-s1qd3x1b	43	26	through	through	IN
cord-252230-s1qd3x1b	43	27	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	43	28	mechanisms	mechanism	NNS
cord-252230-s1qd3x1b	43	29	that	that	WDT
cord-252230-s1qd3x1b	43	30	do	do	VBP
cord-252230-s1qd3x1b	43	31	not	not	RB
cord-252230-s1qd3x1b	43	32	require	require	VB
cord-252230-s1qd3x1b	43	33	insertion	insertion	NN
cord-252230-s1qd3x1b	43	34	into	into	IN
cord-252230-s1qd3x1b	43	35	the	the	DT
cord-252230-s1qd3x1b	43	36	ER	ER	NNP
cord-252230-s1qd3x1b	43	37	and/or	and/or	CC
cord-252230-s1qd3x1b	43	38	bypass	bypass	VB
cord-252230-s1qd3x1b	43	39	the	the	DT
cord-252230-s1qd3x1b	43	40	Golgi	Golgi	NNP
cord-252230-s1qd3x1b	43	41	(	(	-LRB-
cord-252230-s1qd3x1b	43	42	Rabouille	Rabouille	NNP
cord-252230-s1qd3x1b	43	43	et	et	FW
cord-252230-s1qd3x1b	43	44	al	al	NNP
cord-252230-s1qd3x1b	43	45	.	.	.
cord-252230-s1qd3x1b	44	1	,	,	,
cord-252230-s1qd3x1b	44	2	2012	2012	CD
cord-252230-s1qd3x1b	44	3	;	;	:
cord-252230-s1qd3x1b	44	4	Malhotra	Malhotra	NNP
cord-252230-s1qd3x1b	44	5	,	,	,
cord-252230-s1qd3x1b	44	6	2013	2013	CD
cord-252230-s1qd3x1b	44	7	)	)	-RRB-
cord-252230-s1qd3x1b	44	8	.	.	.
cord-252230-s1qd3x1b	45	1	In	in	IN
cord-252230-s1qd3x1b	45	2	addition	addition	NN
cord-252230-s1qd3x1b	45	3	,	,	,
cord-252230-s1qd3x1b	45	4	some	some	DT
cord-252230-s1qd3x1b	45	5	classically	classically	RB
cord-252230-s1qd3x1b	45	6	secreted	secrete	VBN
cord-252230-s1qd3x1b	45	7	proteins	protein	NNS
cord-252230-s1qd3x1b	45	8	appear	appear	VBP
cord-252230-s1qd3x1b	45	9	to	to	TO
cord-252230-s1qd3x1b	45	10	be	be	VB
cord-252230-s1qd3x1b	45	11	preferentially	preferentially	RB
cord-252230-s1qd3x1b	45	12	rerouted	reroute	VBN
cord-252230-s1qd3x1b	45	13	through	through	IN
cord-252230-s1qd3x1b	45	14	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	45	15	pathways	pathway	NNS
cord-252230-s1qd3x1b	45	16	to	to	TO
cord-252230-s1qd3x1b	45	17	facilitate	facilitate	VB
cord-252230-s1qd3x1b	45	18	trafficking	trafficking	NN
cord-252230-s1qd3x1b	45	19	during	during	IN
cord-252230-s1qd3x1b	45	20	stress	stress	NN
cord-252230-s1qd3x1b	45	21	(	(	-LRB-
cord-252230-s1qd3x1b	45	22	Gee	Gee	NNP
cord-252230-s1qd3x1b	45	23	et	et	NNP
cord-252230-s1qd3x1b	45	24	al	al	NNP
cord-252230-s1qd3x1b	45	25	.	.	NNP
cord-252230-s1qd3x1b	45	26	,	,	,
cord-252230-s1qd3x1b	45	27	2011	2011	CD
cord-252230-s1qd3x1b	45	28	)	)	-RRB-
cord-252230-s1qd3x1b	45	29	.	.	.
cord-252230-s1qd3x1b	46	1	Studies	study	NNS
cord-252230-s1qd3x1b	46	2	to	to	IN
cord-252230-s1qd3x1b	46	3	date	date	NN
cord-252230-s1qd3x1b	46	4	have	have	VBP
cord-252230-s1qd3x1b	46	5	uncovered	uncover	VBN
cord-252230-s1qd3x1b	46	6	clear	clear	JJ
cord-252230-s1qd3x1b	46	7	genetic	genetic	JJ
cord-252230-s1qd3x1b	46	8	requirements	requirement	NNS
cord-252230-s1qd3x1b	46	9	for	for	IN
cord-252230-s1qd3x1b	46	10	two	two	CD
cord-252230-s1qd3x1b	46	11	proteins	protein	NNS
cord-252230-s1qd3x1b	46	12	originally	originally	RB
cord-252230-s1qd3x1b	46	13	implicated	implicate	VBN
cord-252230-s1qd3x1b	46	14	in	in	IN
cord-252230-s1qd3x1b	46	15	the	the	DT
cord-252230-s1qd3x1b	46	16	stacking	stacking	NN
cord-252230-s1qd3x1b	46	17	of	of	IN
cord-252230-s1qd3x1b	46	18	the	the	DT
cord-252230-s1qd3x1b	46	19	Golgi	Golgi	NNP
cord-252230-s1qd3x1b	46	20	apparatus	apparatus	NN
cord-252230-s1qd3x1b	46	21	,	,	,
cord-252230-s1qd3x1b	46	22	GRA	GRA	NNP
cord-252230-s1qd3x1b	46	23	SP55	SP55	NNP
cord-252230-s1qd3x1b	46	24	and	and	CC
cord-252230-s1qd3x1b	46	25	GRA	GRA	NNP
cord-252230-s1qd3x1b	46	26	SP65	SP65	NNP
cord-252230-s1qd3x1b	46	27	,	,	,
cord-252230-s1qd3x1b	46	28	as	as	RB
cord-252230-s1qd3x1b	46	29	well	well	RB
cord-252230-s1qd3x1b	46	30	as	as	IN
cord-252230-s1qd3x1b	46	31	ATGs	atg	NNS
cord-252230-s1qd3x1b	46	32	in	in	IN
cord-252230-s1qd3x1b	46	33	mediating	mediate	VBG
cord-252230-s1qd3x1b	46	34	these	these	DT
cord-252230-s1qd3x1b	46	35	alternative	alternative	JJ
cord-252230-s1qd3x1b	46	36	secretory	secretory	JJ
cord-252230-s1qd3x1b	46	37	pathways	pathway	NNS
cord-252230-s1qd3x1b	46	38	(	(	-LRB-
cord-252230-s1qd3x1b	46	39	Rabouille	Rabouille	NNP
cord-252230-s1qd3x1b	46	40	et	et	FW
cord-252230-s1qd3x1b	46	41	al	al	NNP
cord-252230-s1qd3x1b	46	42	.	.	NNP
cord-252230-s1qd3x1b	46	43	,	,	,
cord-252230-s1qd3x1b	46	44	2012	2012	CD
cord-252230-s1qd3x1b	46	45	;	;	:
cord-252230-s1qd3x1b	46	46	Malhotra	Malhotra	NNP
cord-252230-s1qd3x1b	46	47	,	,	,
cord-252230-s1qd3x1b	46	48	2013	2013	CD
cord-252230-s1qd3x1b	46	49	;	;	:
cord-252230-s1qd3x1b	46	50	Zhang	Zhang	NNP
cord-252230-s1qd3x1b	46	51	and	and	CC
cord-252230-s1qd3x1b	46	52	Schekman	Schekman	NNP
cord-252230-s1qd3x1b	46	53	,	,	,
cord-252230-s1qd3x1b	46	54	2013	2013	CD
cord-252230-s1qd3x1b	46	55	)	)	-RRB-
cord-252230-s1qd3x1b	46	56	.	.	.
cord-252230-s1qd3x1b	47	1	ATGs	atg	NNS
cord-252230-s1qd3x1b	47	2	have	have	VBP
cord-252230-s1qd3x1b	47	3	been	be	VBN
cord-252230-s1qd3x1b	47	4	genetically	genetically	RB
cord-252230-s1qd3x1b	47	5	linked	link	VBN
cord-252230-s1qd3x1b	47	6	to	to	IN
cord-252230-s1qd3x1b	47	7	the	the	DT
cord-252230-s1qd3x1b	47	8	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	47	9	secretion	secretion	NN
cord-252230-s1qd3x1b	47	10	of	of	IN
cord-252230-s1qd3x1b	47	11	acyl	acyl	NN
cord-252230-s1qd3x1b	47	12	-	-	HYPH
cord-252230-s1qd3x1b	47	13	CoA	coa	NN
cord-252230-s1qd3x1b	47	14	-	-	HYPH
cord-252230-s1qd3x1b	47	15	binding	bind	VBG
cord-252230-s1qd3x1b	47	16	protein	protein	NN
cord-252230-s1qd3x1b	47	17	Acb1	Acb1	NNP
cord-252230-s1qd3x1b	47	18	in	in	IN
cord-252230-s1qd3x1b	47	19	yeast	yeast	NN
cord-252230-s1qd3x1b	48	1	(	(	-LRB-
cord-252230-s1qd3x1b	48	2	AcbA	AcbA	NNP
cord-252230-s1qd3x1b	48	3	in	in	IN
cord-252230-s1qd3x1b	48	4	Dictyostelium	Dictyostelium	NNP
cord-252230-s1qd3x1b	48	5	discoideum	discoideum	NN
cord-252230-s1qd3x1b	48	6	;	;	:
cord-252230-s1qd3x1b	48	7	Duran	Duran	NNP
cord-252230-s1qd3x1b	48	8	et	et	NNP
cord-252230-s1qd3x1b	48	9	al	al	NNP
cord-252230-s1qd3x1b	48	10	.	.	NNP
cord-252230-s1qd3x1b	48	11	,	,	,
cord-252230-s1qd3x1b	48	12	2010	2010	CD
cord-252230-s1qd3x1b	49	1	;	;	:
cord-252230-s1qd3x1b	49	2	Manjithaya	Manjithaya	NNP
cord-252230-s1qd3x1b	49	3	et	et	NNP
cord-252230-s1qd3x1b	49	4	al	al	NNP
cord-252230-s1qd3x1b	49	5	.	.	NNP
cord-252230-s1qd3x1b	49	6	,	,	,
cord-252230-s1qd3x1b	49	7	2010	2010	CD
cord-252230-s1qd3x1b	49	8	)	)	-RRB-
cord-252230-s1qd3x1b	49	9	,	,	,
cord-252230-s1qd3x1b	49	10	several	several	JJ
cord-252230-s1qd3x1b	49	11	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	49	12	mediators	mediator	NNS
cord-252230-s1qd3x1b	49	13	in	in	IN
cord-252230-s1qd3x1b	49	14	mammalian	mammalian	JJ
cord-252230-s1qd3x1b	49	15	cells	cell	NNS
cord-252230-s1qd3x1b	49	16	,	,	,
cord-252230-s1qd3x1b	49	17	including	include	VBG
cord-252230-s1qd3x1b	49	18	IL-1β	il-1β	NN
cord-252230-s1qd3x1b	49	19	and	and	CC
cord-252230-s1qd3x1b	49	20	IL-18	IL-18	NNP
cord-252230-s1qd3x1b	49	21	;	;	:
cord-252230-s1qd3x1b	49	22	the	the	DT
cord-252230-s1qd3x1b	49	23	high	high	JJ
cord-252230-s1qd3x1b	49	24	mobility	mobility	NN
cord-252230-s1qd3x1b	49	25	group	group	NN
cord-252230-s1qd3x1b	49	26	protein	protein	NN
cord-252230-s1qd3x1b	49	27	B1	b1	NN
cord-252230-s1qd3x1b	49	28	(	(	-LRB-
cord-252230-s1qd3x1b	49	29	HMGB1	HMGB1	NNP
cord-252230-s1qd3x1b	49	30	)	)	-RRB-
cord-252230-s1qd3x1b	49	31	;	;	:
cord-252230-s1qd3x1b	49	32	and	and	CC
cord-252230-s1qd3x1b	49	33	finally	finally	RB
cord-252230-s1qd3x1b	49	34	,	,	,
cord-252230-s1qd3x1b	49	35	the	the	DT
cord-252230-s1qd3x1b	49	36	plasma	plasma	NN
cord-252230-s1qd3x1b	49	37	membrane	membrane	NN
cord-252230-s1qd3x1b	49	38	trafficking	trafficking	NN
cord-252230-s1qd3x1b	49	39	of	of	IN
cord-252230-s1qd3x1b	49	40	the	the	DT
cord-252230-s1qd3x1b	49	41	integral	integral	JJ
cord-252230-s1qd3x1b	49	42	membrane	membrane	NN
cord-252230-s1qd3x1b	49	43	protein	protein	NN
cord-252230-s1qd3x1b	50	1	ΔF508	ΔF508	NNP
cord-252230-s1qd3x1b	50	2	CFTR	CFTR	NNP
cord-252230-s1qd3x1b	51	1	(	(	-LRB-
cord-252230-s1qd3x1b	51	2	Dupont	Dupont	NNP
cord-252230-s1qd3x1b	51	3	et	et	NNP
cord-252230-s1qd3x1b	51	4	al	al	NNP
cord-252230-s1qd3x1b	51	5	.	.	NNP
cord-252230-s1qd3x1b	51	6	,	,	,
cord-252230-s1qd3x1b	51	7	2011	2011	CD
cord-252230-s1qd3x1b	51	8	;	;	:
cord-252230-s1qd3x1b	51	9	Figure	figure	NN
cord-252230-s1qd3x1b	51	10	1	1	CD
cord-252230-s1qd3x1b	51	11	.	.	.
cord-252230-s1qd3x1b	52	1	Classic	classic	JJ
cord-252230-s1qd3x1b	52	2	autophagy	autophagy	NN
cord-252230-s1qd3x1b	52	3	compared	compare	VBN
cord-252230-s1qd3x1b	52	4	with	with	IN
cord-252230-s1qd3x1b	52	5	related	related	JJ
cord-252230-s1qd3x1b	52	6	trafficking	trafficking	NN
cord-252230-s1qd3x1b	52	7	pathways	pathway	NNS
cord-252230-s1qd3x1b	52	8	.	.	.
cord-252230-s1qd3x1b	53	1	(	(	-LRB-
cord-252230-s1qd3x1b	53	2	A	a	DT
cord-252230-s1qd3x1b	53	3	)	)	-RRB-
cord-252230-s1qd3x1b	53	4	Classic	classic	JJ
cord-252230-s1qd3x1b	53	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	53	6	:	:	:
cord-252230-s1qd3x1b	54	1	Diverse	diverse	JJ
cord-252230-s1qd3x1b	54	2	stimuli	stimulus	NNS
cord-252230-s1qd3x1b	54	3	elicit	elicit	VBP
cord-252230-s1qd3x1b	54	4	the	the	DT
cord-252230-s1qd3x1b	54	5	hierarchical	hierarchical	JJ
cord-252230-s1qd3x1b	54	6	recruitment	recruitment	NN
cord-252230-s1qd3x1b	54	7	and	and	CC
cord-252230-s1qd3x1b	54	8	activity	activity	NN
cord-252230-s1qd3x1b	54	9	of	of	IN
cord-252230-s1qd3x1b	54	10	multiple	multiple	JJ
cord-252230-s1qd3x1b	54	11	ATGs	atg	NNS
cord-252230-s1qd3x1b	54	12	(	(	-LRB-
cord-252230-s1qd3x1b	54	13	yellow	yellow	NNP
cord-252230-s1qd3x1b	54	14	)	)	-RRB-
cord-252230-s1qd3x1b	54	15	and	and	CC
cord-252230-s1qd3x1b	54	16	other	other	JJ
cord-252230-s1qd3x1b	54	17	regulatory	regulatory	JJ
cord-252230-s1qd3x1b	54	18	proteins	protein	NNS
cord-252230-s1qd3x1b	54	19	(	(	-LRB-
cord-252230-s1qd3x1b	54	20	blue	blue	NNP
cord-252230-s1qd3x1b	54	21	)	)	-RRB-
cord-252230-s1qd3x1b	54	22	to	to	TO
cord-252230-s1qd3x1b	54	23	construct	construct	VB
cord-252230-s1qd3x1b	54	24	the	the	DT
cord-252230-s1qd3x1b	54	25	double	double	JJ
cord-252230-s1qd3x1b	54	26	membrane	membrane	NN
cord-252230-s1qd3x1b	54	27	autophagosome	autophagosome	NNP
cord-252230-s1qd3x1b	54	28	.	.	.
cord-252230-s1qd3x1b	55	1	The	the	DT
cord-252230-s1qd3x1b	55	2	lipidation	lipidation	NN
cord-252230-s1qd3x1b	55	3	of	of	IN
cord-252230-s1qd3x1b	55	4	LC3	LC3	NNP
cord-252230-s1qd3x1b	55	5	(	(	-LRB-
cord-252230-s1qd3x1b	55	6	LC3-II	LC3-II	NNP
cord-252230-s1qd3x1b	55	7	)	)	-RRB-
cord-252230-s1qd3x1b	55	8	is	be	VBZ
cord-252230-s1qd3x1b	55	9	crucial	crucial	JJ
cord-252230-s1qd3x1b	55	10	for	for	IN
cord-252230-s1qd3x1b	55	11	the	the	DT
cord-252230-s1qd3x1b	55	12	capture	capture	NN
cord-252230-s1qd3x1b	55	13	of	of	IN
cord-252230-s1qd3x1b	55	14	autophagic	autophagic	NNP
cord-252230-s1qd3x1b	55	15	cargo	cargo	NN
cord-252230-s1qd3x1b	55	16	and	and	CC
cord-252230-s1qd3x1b	55	17	to	to	TO
cord-252230-s1qd3x1b	55	18	stabilize	stabilize	VB
cord-252230-s1qd3x1b	55	19	of	of	IN
cord-252230-s1qd3x1b	55	20	the	the	DT
cord-252230-s1qd3x1b	55	21	inner	inner	JJ
cord-252230-s1qd3x1b	55	22	autophagosomal	autophagosomal	NN
cord-252230-s1qd3x1b	55	23	membrane	membrane	NN
cord-252230-s1qd3x1b	55	24	.	.	.
cord-252230-s1qd3x1b	56	1	The	the	DT
cord-252230-s1qd3x1b	56	2	autophagosome	autophagosome	NN
cord-252230-s1qd3x1b	56	3	subsequently	subsequently	RB
cord-252230-s1qd3x1b	56	4	fuses	fuse	VBZ
cord-252230-s1qd3x1b	56	5	with	with	IN
cord-252230-s1qd3x1b	56	6	the	the	DT
cord-252230-s1qd3x1b	56	7	lysosome	lysosome	NN
cord-252230-s1qd3x1b	56	8	in	in	IN
cord-252230-s1qd3x1b	56	9	a	a	DT
cord-252230-s1qd3x1b	56	10	STX17-dependent	stx17-dependent	CD
cord-252230-s1qd3x1b	56	11	manner	manner	NN
cord-252230-s1qd3x1b	56	12	,	,	,
cord-252230-s1qd3x1b	56	13	resulting	result	VBG
cord-252230-s1qd3x1b	56	14	in	in	IN
cord-252230-s1qd3x1b	56	15	degradation	degradation	NN
cord-252230-s1qd3x1b	56	16	of	of	IN
cord-252230-s1qd3x1b	56	17	the	the	DT
cord-252230-s1qd3x1b	56	18	vesicle	vesicle	NN
cord-252230-s1qd3x1b	56	19	contents	content	NNS
cord-252230-s1qd3x1b	56	20	by	by	IN
cord-252230-s1qd3x1b	56	21	lysosomal	lysosomal	JJ
cord-252230-s1qd3x1b	56	22	enzymes	enzyme	NNS
cord-252230-s1qd3x1b	56	23	.	.	.
cord-252230-s1qd3x1b	57	1	(	(	-LRB-
cord-252230-s1qd3x1b	57	2	B	b	NN
cord-252230-s1qd3x1b	57	3	)	)	-RRB-
cord-252230-s1qd3x1b	58	1	Secretory	secretory	JJ
cord-252230-s1qd3x1b	58	2	autophagy	autophagy	NN
cord-252230-s1qd3x1b	58	3	:	:	:
cord-252230-s1qd3x1b	59	1	ATGs	atg	NNS
cord-252230-s1qd3x1b	59	2	mediate	mediate	VBP
cord-252230-s1qd3x1b	59	3	the	the	DT
cord-252230-s1qd3x1b	59	4	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	59	5	secretion	secretion	NN
cord-252230-s1qd3x1b	59	6	of	of	IN
cord-252230-s1qd3x1b	59	7	multiple	multiple	JJ
cord-252230-s1qd3x1b	59	8	proteins	protein	NNS
cord-252230-s1qd3x1b	59	9	(	(	-LRB-
cord-252230-s1qd3x1b	59	10	e.g.	e.g.	RB
cord-252230-s1qd3x1b	59	11	,	,	,
cord-252230-s1qd3x1b	59	12	Acb1	Acb1	NNP
cord-252230-s1qd3x1b	59	13	in	in	IN
cord-252230-s1qd3x1b	59	14	yeast	yeast	NN
cord-252230-s1qd3x1b	59	15	,	,	,
cord-252230-s1qd3x1b	59	16	and	and	CC
cord-252230-s1qd3x1b	59	17	IL-1β	IL-1β	NNP
cord-252230-s1qd3x1b	59	18	,	,	,
cord-252230-s1qd3x1b	59	19	IL-18	IL-18	NNP
cord-252230-s1qd3x1b	59	20	,	,	,
cord-252230-s1qd3x1b	59	21	and	and	CC
cord-252230-s1qd3x1b	59	22	HMGB1	HMGB1	NNP
cord-252230-s1qd3x1b	59	23	in	in	IN
cord-252230-s1qd3x1b	59	24	mammalian	mammalian	JJ
cord-252230-s1qd3x1b	59	25	cells	cell	NNS
cord-252230-s1qd3x1b	59	26	)	)	-RRB-
cord-252230-s1qd3x1b	59	27	that	that	WDT
cord-252230-s1qd3x1b	59	28	lack	lack	VBP
cord-252230-s1qd3x1b	59	29	an	an	DT
cord-252230-s1qd3x1b	59	30	N	n	CD
cord-252230-s1qd3x1b	59	31	-	-	HYPH
cord-252230-s1qd3x1b	59	32	terminal	terminal	NN
cord-252230-s1qd3x1b	59	33	signal	signal	NN
cord-252230-s1qd3x1b	59	34	sequence	sequence	NN
cord-252230-s1qd3x1b	59	35	.	.	.
cord-252230-s1qd3x1b	60	1	These	these	DT
cord-252230-s1qd3x1b	60	2	targets	target	NNS
cord-252230-s1qd3x1b	60	3	are	be	VBP
cord-252230-s1qd3x1b	60	4	postulated	postulate	VBN
cord-252230-s1qd3x1b	60	5	to	to	TO
cord-252230-s1qd3x1b	60	6	be	be	VB
cord-252230-s1qd3x1b	60	7	released	release	VBN
cord-252230-s1qd3x1b	60	8	via	via	IN
cord-252230-s1qd3x1b	60	9	several	several	JJ
cord-252230-s1qd3x1b	60	10	putative	putative	JJ
cord-252230-s1qd3x1b	60	11	mechanisms	mechanism	NNS
cord-252230-s1qd3x1b	60	12	.	.	.
cord-252230-s1qd3x1b	61	1	First	first	RB
cord-252230-s1qd3x1b	61	2	,	,	,
cord-252230-s1qd3x1b	61	3	the	the	DT
cord-252230-s1qd3x1b	61	4	ATG	ATG	NNP
cord-252230-s1qd3x1b	61	5	conjugation	conjugation	NN
cord-252230-s1qd3x1b	61	6	machinery	machinery	NN
cord-252230-s1qd3x1b	61	7	promotes	promote	VBZ
cord-252230-s1qd3x1b	61	8	the	the	DT
cord-252230-s1qd3x1b	61	9	formation	formation	NN
cord-252230-s1qd3x1b	61	10	of	of	IN
cord-252230-s1qd3x1b	61	11	an	an	DT
cord-252230-s1qd3x1b	61	12	LC3	lc3	JJ
cord-252230-s1qd3x1b	61	13	+	+	CC
cord-252230-s1qd3x1b	61	14	autophagosome	autophagosome	NN
cord-252230-s1qd3x1b	61	15	-	-	HYPH
cord-252230-s1qd3x1b	61	16	like	like	JJ
cord-252230-s1qd3x1b	61	17	intermediate	intermediate	JJ
cord-252230-s1qd3x1b	61	18	,	,	,
cord-252230-s1qd3x1b	61	19	and	and	CC
cord-252230-s1qd3x1b	61	20	the	the	DT
cord-252230-s1qd3x1b	61	21	contents	content	NNS
cord-252230-s1qd3x1b	61	22	enwrapped	enwrapped	NNS
cord-252230-s1qd3x1b	61	23	within	within	IN
cord-252230-s1qd3x1b	61	24	the	the	DT
cord-252230-s1qd3x1b	61	25	inner	inner	JJ
cord-252230-s1qd3x1b	61	26	membrane	membrane	NN
cord-252230-s1qd3x1b	61	27	of	of	IN
cord-252230-s1qd3x1b	61	28	autophagosome	autophagosome	NNP
cord-252230-s1qd3x1b	61	29	are	be	VBP
cord-252230-s1qd3x1b	61	30	released	release	VBN
cord-252230-s1qd3x1b	61	31	extracellularly	extracellularly	RB
cord-252230-s1qd3x1b	61	32	instead	instead	RB
cord-252230-s1qd3x1b	61	33	of	of	IN
cord-252230-s1qd3x1b	61	34	degraded	degrade	VBN
cord-252230-s1qd3x1b	61	35	in	in	IN
cord-252230-s1qd3x1b	61	36	lysosomes	lysosome	NNS
cord-252230-s1qd3x1b	61	37	.	.	.
cord-252230-s1qd3x1b	62	1	Second	second	RB
cord-252230-s1qd3x1b	62	2	,	,	,
cord-252230-s1qd3x1b	62	3	targets	target	NNS
cord-252230-s1qd3x1b	62	4	of	of	IN
cord-252230-s1qd3x1b	62	5	secretory	secretory	JJ
cord-252230-s1qd3x1b	62	6	autophagy	autophagy	NN
cord-252230-s1qd3x1b	62	7	,	,	,
cord-252230-s1qd3x1b	62	8	such	such	JJ
cord-252230-s1qd3x1b	62	9	as	as	IN
cord-252230-s1qd3x1b	62	10	IL-1β	IL-1β	NNP
cord-252230-s1qd3x1b	62	11	,	,	,
cord-252230-s1qd3x1b	62	12	are	be	VBP
cord-252230-s1qd3x1b	62	13	translocated	translocate	VBN
cord-252230-s1qd3x1b	62	14	into	into	IN
cord-252230-s1qd3x1b	62	15	the	the	DT
cord-252230-s1qd3x1b	62	16	intramembrane	intramembrane	NNP
cord-252230-s1qd3x1b	62	17	space	space	NN
cord-252230-s1qd3x1b	62	18	of	of	IN
cord-252230-s1qd3x1b	62	19	an	an	DT
cord-252230-s1qd3x1b	62	20	LC3	lc3	JJ
cord-252230-s1qd3x1b	62	21	+	+	SYM
cord-252230-s1qd3x1b	62	22	double	double	JJ
cord-252230-s1qd3x1b	62	23	membrane	membrane	NN
cord-252230-s1qd3x1b	62	24	vesicular	vesicular	JJ
cord-252230-s1qd3x1b	62	25	intermediate	intermediate	NN
cord-252230-s1qd3x1b	62	26	that	that	IN
cord-252230-s1qd3x1b	62	27	fuses	fuse	VBZ
cord-252230-s1qd3x1b	62	28	directly	directly	RB
cord-252230-s1qd3x1b	62	29	with	with	IN
cord-252230-s1qd3x1b	62	30	the	the	DT
cord-252230-s1qd3x1b	62	31	plasma	plasma	NN
cord-252230-s1qd3x1b	62	32	membrane	membrane	NN
cord-252230-s1qd3x1b	62	33	or	or	CC
cord-252230-s1qd3x1b	62	34	fuses	fuse	NNS
cord-252230-s1qd3x1b	62	35	with	with	IN
cord-252230-s1qd3x1b	62	36	a	a	DT
cord-252230-s1qd3x1b	62	37	MVB	mvb	NN
cord-252230-s1qd3x1b	62	38	intermediate	intermediate	JJ
cord-252230-s1qd3x1b	62	39	that	that	WDT
cord-252230-s1qd3x1b	62	40	is	be	VBZ
cord-252230-s1qd3x1b	62	41	secreted	secrete	VBN
cord-252230-s1qd3x1b	62	42	.	.	.
cord-252230-s1qd3x1b	63	1	Last	last	RB
cord-252230-s1qd3x1b	63	2	,	,	,
cord-252230-s1qd3x1b	63	3	although	although	IN
cord-252230-s1qd3x1b	63	4	formal	formal	JJ
cord-252230-s1qd3x1b	63	5	experimental	experimental	JJ
cord-252230-s1qd3x1b	63	6	evidence	evidence	NN
cord-252230-s1qd3x1b	63	7	is	be	VBZ
cord-252230-s1qd3x1b	63	8	lacking	lack	VBG
cord-252230-s1qd3x1b	63	9	,	,	,
cord-252230-s1qd3x1b	63	10	secretory	secretory	JJ
cord-252230-s1qd3x1b	63	11	autophagy	autophagy	NN
cord-252230-s1qd3x1b	63	12	may	may	MD
cord-252230-s1qd3x1b	63	13	involve	involve	VB
cord-252230-s1qd3x1b	63	14	an	an	DT
cord-252230-s1qd3x1b	63	15	MVB	MVB	NNP
cord-252230-s1qd3x1b	63	16	/	/	SYM
cord-252230-s1qd3x1b	63	17	amphisome	amphisome	VBN
cord-252230-s1qd3x1b	63	18	intermediate	intermediate	JJ
cord-252230-s1qd3x1b	63	19	and	and	CC
cord-252230-s1qd3x1b	63	20	the	the	DT
cord-252230-s1qd3x1b	63	21	exocytic	exocytic	JJ
cord-252230-s1qd3x1b	63	22	release	release	NN
cord-252230-s1qd3x1b	63	23	of	of	IN
cord-252230-s1qd3x1b	63	24	small	small	JJ
cord-252230-s1qd3x1b	63	25	extracellular	extracellular	JJ
cord-252230-s1qd3x1b	63	26	microvesicles	microvesicle	NNS
cord-252230-s1qd3x1b	63	27	.	.	.
cord-252230-s1qd3x1b	64	1	Regardless	regardless	RB
cord-252230-s1qd3x1b	64	2	of	of	IN
cord-252230-s1qd3x1b	64	3	the	the	DT
cord-252230-s1qd3x1b	64	4	exact	exact	JJ
cord-252230-s1qd3x1b	64	5	pathway	pathway	NN
cord-252230-s1qd3x1b	64	6	,	,	,
cord-252230-s1qd3x1b	64	7	recent	recent	JJ
cord-252230-s1qd3x1b	64	8	work	work	NN
cord-252230-s1qd3x1b	64	9	indicates	indicate	VBZ
cord-252230-s1qd3x1b	64	10	that	that	IN
cord-252230-s1qd3x1b	64	11	secretory	secretory	JJ
cord-252230-s1qd3x1b	64	12	autophagy	autophagy	NN
cord-252230-s1qd3x1b	64	13	proceeds	proceed	VBZ
cord-252230-s1qd3x1b	64	14	through	through	IN
cord-252230-s1qd3x1b	64	15	a	a	DT
cord-252230-s1qd3x1b	64	16	dedicated	dedicated	JJ
cord-252230-s1qd3x1b	64	17	SNA	SNA	NNP
cord-252230-s1qd3x1b	64	18	RE	RE	NNP
cord-252230-s1qd3x1b	64	19	machinery	machinery	NN
cord-252230-s1qd3x1b	64	20	,	,	,
cord-252230-s1qd3x1b	64	21	which	which	WDT
cord-252230-s1qd3x1b	64	22	diverts	divert	VBZ
cord-252230-s1qd3x1b	64	23	secreted	secrete	VBN
cord-252230-s1qd3x1b	64	24	targets	target	NNS
cord-252230-s1qd3x1b	64	25	away	away	RB
cord-252230-s1qd3x1b	64	26	from	from	IN
cord-252230-s1qd3x1b	64	27	the	the	DT
cord-252230-s1qd3x1b	64	28	lysosome	lysosome	NN
cord-252230-s1qd3x1b	64	29	and	and	CC
cord-252230-s1qd3x1b	64	30	toward	toward	IN
cord-252230-s1qd3x1b	64	31	the	the	DT
cord-252230-s1qd3x1b	64	32	plasma	plasma	NN
cord-252230-s1qd3x1b	64	33	membrane	membrane	NN
cord-252230-s1qd3x1b	64	34	(	(	-LRB-
cord-252230-s1qd3x1b	64	35	PM	PM	NNP
cord-252230-s1qd3x1b	64	36	)	)	-RRB-
cord-252230-s1qd3x1b	64	37	.	.	.
cord-252230-s1qd3x1b	65	1	(	(	-LRB-
cord-252230-s1qd3x1b	65	2	C	C	NNP
cord-252230-s1qd3x1b	65	3	)	)	-RRB-
cord-252230-s1qd3x1b	65	4	LAP	lap	NN
cord-252230-s1qd3x1b	65	5	:	:	:
cord-252230-s1qd3x1b	66	1	the	the	DT
cord-252230-s1qd3x1b	66	2	phagocytosis	phagocytosis	NN
cord-252230-s1qd3x1b	66	3	of	of	IN
cord-252230-s1qd3x1b	66	4	pathogens	pathogen	NNS
cord-252230-s1qd3x1b	66	5	and	and	CC
cord-252230-s1qd3x1b	66	6	other	other	JJ
cord-252230-s1qd3x1b	66	7	prey	prey	NN
cord-252230-s1qd3x1b	66	8	in	in	IN
cord-252230-s1qd3x1b	66	9	certain	certain	JJ
cord-252230-s1qd3x1b	66	10	cell	cell	NN
cord-252230-s1qd3x1b	66	11	types	type	NNS
cord-252230-s1qd3x1b	66	12	(	(	-LRB-
cord-252230-s1qd3x1b	66	13	e.g.	e.g.	RB
cord-252230-s1qd3x1b	66	14	,	,	,
cord-252230-s1qd3x1b	66	15	macrophages	macrophage	NNS
cord-252230-s1qd3x1b	66	16	and	and	CC
cord-252230-s1qd3x1b	66	17	dendritic	dendritic	JJ
cord-252230-s1qd3x1b	66	18	cells	cell	NNS
cord-252230-s1qd3x1b	66	19	)	)	-RRB-
cord-252230-s1qd3x1b	66	20	recruits	recruit	VBZ
cord-252230-s1qd3x1b	66	21	UVR	UVR	NNP
cord-252230-s1qd3x1b	66	22	AG	AG	NNP
cord-252230-s1qd3x1b	66	23	and	and	CC
cord-252230-s1qd3x1b	66	24	Rubicon	Rubicon	NNP
cord-252230-s1qd3x1b	66	25	(	(	-LRB-
cord-252230-s1qd3x1b	66	26	RUB	RUB	NNP
cord-252230-s1qd3x1b	66	27	CN	CN	NNP
cord-252230-s1qd3x1b	66	28	)	)	-RRB-
cord-252230-s1qd3x1b	66	29	,	,	,
cord-252230-s1qd3x1b	66	30	thereby	thereby	RB
cord-252230-s1qd3x1b	66	31	activating	activate	VBG
cord-252230-s1qd3x1b	66	32	the	the	DT
cord-252230-s1qd3x1b	66	33	Beclin-1-VPS34	Beclin-1-VPS34	NNP
cord-252230-s1qd3x1b	66	34	complex	complex	JJ
cord-252230-s1qd3x1b	66	35	to	to	TO
cord-252230-s1qd3x1b	66	36	generate	generate	VB
cord-252230-s1qd3x1b	66	37	phosphatidylinositol	phosphatidylinositol	JJ
cord-252230-s1qd3x1b	66	38	3-phosphate	3-phosphate	CD
cord-252230-s1qd3x1b	66	39	and	and	CC
cord-252230-s1qd3x1b	66	40	NOX2	NOX2	NNP
cord-252230-s1qd3x1b	66	41	,	,	,
cord-252230-s1qd3x1b	66	42	an	an	DT
cord-252230-s1qd3x1b	66	43	NAD	NAD	NNP
cord-252230-s1qd3x1b	66	44	PH	PH	NNP
cord-252230-s1qd3x1b	66	45	oxidase	oxidase	NN
cord-252230-s1qd3x1b	66	46	that	that	WDT
cord-252230-s1qd3x1b	66	47	generates	generate	VBZ
cord-252230-s1qd3x1b	66	48	ROS	ROS	NNP
cord-252230-s1qd3x1b	66	49	inside	inside	IN
cord-252230-s1qd3x1b	66	50	the	the	DT
cord-252230-s1qd3x1b	66	51	phagosome	phagosome	NN
cord-252230-s1qd3x1b	66	52	.	.	.
cord-252230-s1qd3x1b	67	1	This	this	DT
cord-252230-s1qd3x1b	67	2	subsequently	subsequently	RB
cord-252230-s1qd3x1b	67	3	triggers	trigger	VBZ
cord-252230-s1qd3x1b	67	4	the	the	DT
cord-252230-s1qd3x1b	67	5	recruitment	recruitment	NN
cord-252230-s1qd3x1b	67	6	and	and	CC
cord-252230-s1qd3x1b	67	7	activation	activation	NN
cord-252230-s1qd3x1b	67	8	of	of	IN
cord-252230-s1qd3x1b	67	9	the	the	DT
cord-252230-s1qd3x1b	67	10	ATG	ATG	NNP
cord-252230-s1qd3x1b	67	11	conjugation	conjugation	NN
cord-252230-s1qd3x1b	67	12	machinery	machinery	NN
cord-252230-s1qd3x1b	67	13	,	,	,
cord-252230-s1qd3x1b	67	14	which	which	WDT
cord-252230-s1qd3x1b	67	15	mediates	mediate	VBZ
cord-252230-s1qd3x1b	67	16	LC3-II	lc3-ii	NN
cord-252230-s1qd3x1b	67	17	at	at	IN
cord-252230-s1qd3x1b	67	18	the	the	DT
cord-252230-s1qd3x1b	67	19	single	single	JJ
cord-252230-s1qd3x1b	67	20	membrane	membrane	NN
cord-252230-s1qd3x1b	67	21	phagosome	phagosome	NN
cord-252230-s1qd3x1b	67	22	.	.	.
cord-252230-s1qd3x1b	68	1	LC3-II	LC3-II	NNP
cord-252230-s1qd3x1b	68	2	expedites	expedite	VBZ
cord-252230-s1qd3x1b	68	3	fusion	fusion	NN
cord-252230-s1qd3x1b	68	4	to	to	IN
cord-252230-s1qd3x1b	68	5	lysosomes	lysosome	NNS
cord-252230-s1qd3x1b	68	6	and	and	CC
cord-252230-s1qd3x1b	68	7	degradation	degradation	NN
cord-252230-s1qd3x1b	68	8	of	of	IN
cord-252230-s1qd3x1b	68	9	the	the	DT
cord-252230-s1qd3x1b	68	10	offending	offend	VBG
cord-252230-s1qd3x1b	68	11	pathogen	pathogen	NN
cord-252230-s1qd3x1b	68	12	.	.	.
cord-252230-s1qd3x1b	69	1	Gee	Gee	NNP
cord-252230-s1qd3x1b	69	2	et	et	NNP
cord-252230-s1qd3x1b	69	3	al	al	NNP
cord-252230-s1qd3x1b	69	4	.	.	NNP
cord-252230-s1qd3x1b	69	5	,	,	,
cord-252230-s1qd3x1b	69	6	2011	2011	CD
cord-252230-s1qd3x1b	69	7	)	)	-RRB-
cord-252230-s1qd3x1b	69	8	.	.	.
cord-252230-s1qd3x1b	70	1	To	to	IN
cord-252230-s1qd3x1b	70	2	date	date	NN
cord-252230-s1qd3x1b	70	3	,	,	,
cord-252230-s1qd3x1b	70	4	apart	apart	RB
cord-252230-s1qd3x1b	70	5	from	from	IN
cord-252230-s1qd3x1b	70	6	these	these	DT
cord-252230-s1qd3x1b	70	7	limited	limited	JJ
cord-252230-s1qd3x1b	70	8	targets	target	NNS
cord-252230-s1qd3x1b	70	9	,	,	,
cord-252230-s1qd3x1b	70	10	the	the	DT
cord-252230-s1qd3x1b	70	11	broader	broad	JJR
cord-252230-s1qd3x1b	70	12	autophagy	autophagy	NN
cord-252230-s1qd3x1b	70	13	-	-	HYPH
cord-252230-s1qd3x1b	70	14	dependent	dependent	JJ
cord-252230-s1qd3x1b	70	15	secretome	secretome	NN
cord-252230-s1qd3x1b	70	16	remains	remain	VBZ
cord-252230-s1qd3x1b	70	17	uncharacterized	uncharacterized	JJ
cord-252230-s1qd3x1b	70	18	.	.	.
cord-252230-s1qd3x1b	71	1	Accordingly	accordingly	RB
cord-252230-s1qd3x1b	71	2	,	,	,
cord-252230-s1qd3x1b	71	3	recent	recent	JJ
cord-252230-s1qd3x1b	71	4	quantitative	quantitative	JJ
cord-252230-s1qd3x1b	71	5	proteomic	proteomic	JJ
cord-252230-s1qd3x1b	71	6	analysis	analysis	NN
cord-252230-s1qd3x1b	71	7	of	of	IN
cord-252230-s1qd3x1b	71	8	the	the	DT
cord-252230-s1qd3x1b	71	9	secretome	secretome	NN
cord-252230-s1qd3x1b	71	10	from	from	IN
cord-252230-s1qd3x1b	71	11	ATG5-deficient	atg5-deficient	JJ
cord-252230-s1qd3x1b	71	12	macrophages	macrophage	NNS
cord-252230-s1qd3x1b	71	13	has	have	VBZ
cord-252230-s1qd3x1b	71	14	uncovered	uncover	VBN
cord-252230-s1qd3x1b	71	15	new	new	JJ
cord-252230-s1qd3x1b	71	16	leaderless	leaderless	JJ
cord-252230-s1qd3x1b	71	17	proteins	protein	NNS
cord-252230-s1qd3x1b	71	18	that	that	WDT
cord-252230-s1qd3x1b	71	19	may	may	MD
cord-252230-s1qd3x1b	71	20	be	be	VB
cord-252230-s1qd3x1b	71	21	secreted	secrete	VBN
cord-252230-s1qd3x1b	71	22	in	in	IN
cord-252230-s1qd3x1b	71	23	an	an	DT
cord-252230-s1qd3x1b	71	24	autophagydependent	autophagydependent	NN
cord-252230-s1qd3x1b	71	25	manner	manner	NN
cord-252230-s1qd3x1b	71	26	(	(	-LRB-
cord-252230-s1qd3x1b	71	27	Kimura	Kimura	NNP
cord-252230-s1qd3x1b	71	28	et	et	FW
cord-252230-s1qd3x1b	71	29	al	al	NNP
cord-252230-s1qd3x1b	71	30	.	.	NNP
cord-252230-s1qd3x1b	71	31	,	,	,
cord-252230-s1qd3x1b	71	32	2017	2017	CD
cord-252230-s1qd3x1b	71	33	)	)	-RRB-
cord-252230-s1qd3x1b	71	34	.	.	.
cord-252230-s1qd3x1b	72	1	However	however	RB
cord-252230-s1qd3x1b	72	2	,	,	,
cord-252230-s1qd3x1b	72	3	it	-PRON-	PRP
cord-252230-s1qd3x1b	72	4	remains	remain	VBZ
cord-252230-s1qd3x1b	72	5	unclear	unclear	JJ
cord-252230-s1qd3x1b	72	6	from	from	IN
cord-252230-s1qd3x1b	72	7	these	these	DT
cord-252230-s1qd3x1b	72	8	genetic	genetic	JJ
cord-252230-s1qd3x1b	72	9	loss	loss	NN
cord-252230-s1qd3x1b	72	10	-	-	HYPH
cord-252230-s1qd3x1b	72	11	of	of	IN
cord-252230-s1qd3x1b	72	12	-	-	HYPH
cord-252230-s1qd3x1b	72	13	function	function	NN
cord-252230-s1qd3x1b	72	14	studies	study	NNS
cord-252230-s1qd3x1b	72	15	whether	whether	IN
cord-252230-s1qd3x1b	72	16	the	the	DT
cord-252230-s1qd3x1b	72	17	observed	observed	JJ
cord-252230-s1qd3x1b	72	18	secretory	secretory	JJ
cord-252230-s1qd3x1b	72	19	defects	defect	NNS
cord-252230-s1qd3x1b	72	20	represent	represent	VBP
cord-252230-s1qd3x1b	72	21	a	a	DT
cord-252230-s1qd3x1b	72	22	direct	direct	JJ
cord-252230-s1qd3x1b	72	23	versus	versus	IN
cord-252230-s1qd3x1b	72	24	indirect	indirect	JJ
cord-252230-s1qd3x1b	72	25	consequence	consequence	NN
cord-252230-s1qd3x1b	72	26	of	of	IN
cord-252230-s1qd3x1b	72	27	impaired	impaired	JJ
cord-252230-s1qd3x1b	72	28	autophagy	autophagy	NN
cord-252230-s1qd3x1b	72	29	.	.	.
cord-252230-s1qd3x1b	73	1	The	the	DT
cord-252230-s1qd3x1b	73	2	mechanistic	mechanistic	JJ
cord-252230-s1qd3x1b	73	3	underpinnings	underpinning	NNS
cord-252230-s1qd3x1b	73	4	of	of	IN
cord-252230-s1qd3x1b	73	5	secretory	secretory	JJ
cord-252230-s1qd3x1b	73	6	autophagy	autophagy	NN
cord-252230-s1qd3x1b	73	7	are	be	VBP
cord-252230-s1qd3x1b	73	8	only	only	RB
cord-252230-s1qd3x1b	73	9	beginning	begin	VBG
cord-252230-s1qd3x1b	73	10	to	to	TO
cord-252230-s1qd3x1b	73	11	emerge	emerge	VB
cord-252230-s1qd3x1b	73	12	,	,	,
cord-252230-s1qd3x1b	73	13	and	and	CC
cord-252230-s1qd3x1b	73	14	numerous	numerous	JJ
cord-252230-s1qd3x1b	73	15	questions	question	NNS
cord-252230-s1qd3x1b	73	16	remain	remain	VBP
cord-252230-s1qd3x1b	73	17	unaddressed	unaddressed	JJ
cord-252230-s1qd3x1b	73	18	.	.	.
cord-252230-s1qd3x1b	74	1	First	first	RB
cord-252230-s1qd3x1b	74	2	,	,	,
cord-252230-s1qd3x1b	74	3	despite	despite	IN
cord-252230-s1qd3x1b	74	4	the	the	DT
cord-252230-s1qd3x1b	74	5	genetic	genetic	JJ
cord-252230-s1qd3x1b	74	6	interconnections	interconnection	NNS
cord-252230-s1qd3x1b	74	7	between	between	IN
cord-252230-s1qd3x1b	74	8	ATGs	atg	NNS
cord-252230-s1qd3x1b	74	9	and	and	CC
cord-252230-s1qd3x1b	74	10	Grh1	Grh1	NNP
cord-252230-s1qd3x1b	74	11	,	,	,
cord-252230-s1qd3x1b	74	12	the	the	DT
cord-252230-s1qd3x1b	74	13	yeast	yeast	NN
cord-252230-s1qd3x1b	74	14	GRA	GRA	NNP
cord-252230-s1qd3x1b	74	15	SP	SP	NNP
cord-252230-s1qd3x1b	74	16	orthologue	orthologue	NN
cord-252230-s1qd3x1b	74	17	,	,	,
cord-252230-s1qd3x1b	74	18	in	in	IN
cord-252230-s1qd3x1b	74	19	S.	S.	NNP
cord-252230-s1qd3x1b	74	20	cerevisiae	cerevisiae	NNS
cord-252230-s1qd3x1b	74	21	,	,	,
cord-252230-s1qd3x1b	74	22	recent	recent	JJ
cord-252230-s1qd3x1b	74	23	work	work	NN
cord-252230-s1qd3x1b	74	24	questions	question	NNS
cord-252230-s1qd3x1b	74	25	whether	whether	IN
cord-252230-s1qd3x1b	74	26	autophagy	autophagy	NN
cord-252230-s1qd3x1b	74	27	and	and	CC
cord-252230-s1qd3x1b	74	28	Grh1	Grh1	NNP
cord-252230-s1qd3x1b	74	29	truly	truly	RB
cord-252230-s1qd3x1b	74	30	converge	converge	VBP
cord-252230-s1qd3x1b	74	31	on	on	IN
cord-252230-s1qd3x1b	74	32	a	a	DT
cord-252230-s1qd3x1b	74	33	common	common	JJ
cord-252230-s1qd3x1b	74	34	secretory	secretory	JJ
cord-252230-s1qd3x1b	74	35	pathway	pathway	NN
cord-252230-s1qd3x1b	74	36	(	(	-LRB-
cord-252230-s1qd3x1b	75	1	Cruz	Cruz	NNP
cord-252230-s1qd3x1b	75	2	-	-	HYPH
cord-252230-s1qd3x1b	75	3	Garcia	Garcia	NNP
cord-252230-s1qd3x1b	75	4	et	et	NNP
cord-252230-s1qd3x1b	75	5	al	al	NNP
cord-252230-s1qd3x1b	75	6	.	.	.
cord-252230-s1qd3x1b	76	1	,	,	,
cord-252230-s1qd3x1b	76	2	2014	2014	CD
cord-252230-s1qd3x1b	76	3	)	)	-RRB-
cord-252230-s1qd3x1b	76	4	.	.	.
cord-252230-s1qd3x1b	77	1	Second	second	RB
cord-252230-s1qd3x1b	77	2	,	,	,
cord-252230-s1qd3x1b	77	3	although	although	IN
cord-252230-s1qd3x1b	77	4	ATGs	atg	NNS
cord-252230-s1qd3x1b	77	5	that	that	WDT
cord-252230-s1qd3x1b	77	6	promote	promote	VBP
cord-252230-s1qd3x1b	77	7	early	early	JJ
cord-252230-s1qd3x1b	77	8	autophagosome	autophagosome	JJ
cord-252230-s1qd3x1b	77	9	formation	formation	NN
cord-252230-s1qd3x1b	77	10	are	be	VBP
cord-252230-s1qd3x1b	77	11	genetically	genetically	RB
cord-252230-s1qd3x1b	77	12	required	require	VBN
cord-252230-s1qd3x1b	77	13	for	for	IN
cord-252230-s1qd3x1b	77	14	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	77	15	secretion	secretion	NN
cord-252230-s1qd3x1b	77	16	,	,	,
cord-252230-s1qd3x1b	77	17	it	-PRON-	PRP
cord-252230-s1qd3x1b	77	18	is	be	VBZ
cord-252230-s1qd3x1b	77	19	unclear	unclear	JJ
cord-252230-s1qd3x1b	77	20	whether	whether	IN
cord-252230-s1qd3x1b	77	21	secretory	secretory	JJ
cord-252230-s1qd3x1b	77	22	autophagy	autophagy	NN
cord-252230-s1qd3x1b	77	23	targets	target	NNS
cord-252230-s1qd3x1b	77	24	are	be	VBP
cord-252230-s1qd3x1b	77	25	actually	actually	RB
cord-252230-s1qd3x1b	77	26	captured	capture	VBN
cord-252230-s1qd3x1b	77	27	into	into	IN
cord-252230-s1qd3x1b	77	28	the	the	DT
cord-252230-s1qd3x1b	77	29	autophagosomal	autophagosomal	NNP
cord-252230-s1qd3x1b	77	30	lumen	lumen	NN
cord-252230-s1qd3x1b	77	31	(	(	-LRB-
cord-252230-s1qd3x1b	77	32	Fig	Fig	NNP
cord-252230-s1qd3x1b	77	33	.	.	.
cord-252230-s1qd3x1b	77	34	1	1	CD
cord-252230-s1qd3x1b	77	35	B	b	NN
cord-252230-s1qd3x1b	77	36	)	)	-RRB-
cord-252230-s1qd3x1b	77	37	.	.	.
cord-252230-s1qd3x1b	78	1	In	in	IN
cord-252230-s1qd3x1b	78	2	fact	fact	NN
cord-252230-s1qd3x1b	78	3	,	,	,
cord-252230-s1qd3x1b	78	4	recent	recent	JJ
cord-252230-s1qd3x1b	78	5	work	work	NN
cord-252230-s1qd3x1b	78	6	demonstrates	demonstrate	VBZ
cord-252230-s1qd3x1b	78	7	that	that	IN
cord-252230-s1qd3x1b	78	8	IL-1β	il-1β	DT
cord-252230-s1qd3x1b	78	9	secretion	secretion	NN
cord-252230-s1qd3x1b	78	10	requires	require	VBZ
cord-252230-s1qd3x1b	78	11	ATGs	atg	NNS
cord-252230-s1qd3x1b	78	12	but	but	CC
cord-252230-s1qd3x1b	78	13	proceeds	proceed	VBZ
cord-252230-s1qd3x1b	78	14	via	via	IN
cord-252230-s1qd3x1b	78	15	translocation	translocation	NN
cord-252230-s1qd3x1b	78	16	into	into	IN
cord-252230-s1qd3x1b	78	17	the	the	DT
cord-252230-s1qd3x1b	78	18	intermembrane	intermembrane	NN
cord-252230-s1qd3x1b	78	19	space	space	NN
cord-252230-s1qd3x1b	78	20	of	of	IN
cord-252230-s1qd3x1b	78	21	the	the	DT
cord-252230-s1qd3x1b	78	22	autophagosome	autophagosome	NNP
cord-252230-s1qd3x1b	79	1	(	(	-LRB-
cord-252230-s1qd3x1b	79	2	Zhang	Zhang	NNP
cord-252230-s1qd3x1b	79	3	et	et	NNP
cord-252230-s1qd3x1b	79	4	al	al	NNP
cord-252230-s1qd3x1b	79	5	.	.	NNP
cord-252230-s1qd3x1b	79	6	,	,	,
cord-252230-s1qd3x1b	79	7	2015	2015	CD
cord-252230-s1qd3x1b	79	8	;	;	:
cord-252230-s1qd3x1b	79	9	Fig	Fig	NNP
cord-252230-s1qd3x1b	79	10	.	.	.
cord-252230-s1qd3x1b	80	1	1	1	CD
cord-252230-s1qd3x1b	80	2	B	b	NN
cord-252230-s1qd3x1b	80	3	)	)	-RRB-
cord-252230-s1qd3x1b	80	4	.	.	.
cord-252230-s1qd3x1b	81	1	Third	third	RB
cord-252230-s1qd3x1b	81	2	,	,	,
cord-252230-s1qd3x1b	81	3	it	-PRON-	PRP
cord-252230-s1qd3x1b	81	4	remains	remain	VBZ
cord-252230-s1qd3x1b	81	5	unclear	unclear	JJ
cord-252230-s1qd3x1b	81	6	how	how	WRB
cord-252230-s1qd3x1b	81	7	secreted	secreted	JJ
cord-252230-s1qd3x1b	81	8	targets	target	NNS
cord-252230-s1qd3x1b	81	9	are	be	VBP
cord-252230-s1qd3x1b	81	10	transported	transport	VBN
cord-252230-s1qd3x1b	81	11	to	to	IN
cord-252230-s1qd3x1b	81	12	the	the	DT
cord-252230-s1qd3x1b	81	13	cell	cell	NN
cord-252230-s1qd3x1b	81	14	surface	surface	NN
cord-252230-s1qd3x1b	81	15	.	.	.
cord-252230-s1qd3x1b	82	1	Because	because	IN
cord-252230-s1qd3x1b	82	2	evidence	evidence	NN
cord-252230-s1qd3x1b	82	3	supports	support	VBZ
cord-252230-s1qd3x1b	82	4	that	that	IN
cord-252230-s1qd3x1b	82	5	contents	content	NNS
cord-252230-s1qd3x1b	82	6	of	of	IN
cord-252230-s1qd3x1b	82	7	multivesicular	multivesicular	NNP
cord-252230-s1qd3x1b	82	8	bodies	body	NNS
cord-252230-s1qd3x1b	82	9	(	(	-LRB-
cord-252230-s1qd3x1b	82	10	MVBs	MVBs	NNP
cord-252230-s1qd3x1b	82	11	)	)	-RRB-
cord-252230-s1qd3x1b	82	12	can	can	MD
cord-252230-s1qd3x1b	82	13	be	be	VB
cord-252230-s1qd3x1b	82	14	directly	directly	RB
cord-252230-s1qd3x1b	82	15	exported	export	VBN
cord-252230-s1qd3x1b	82	16	to	to	IN
cord-252230-s1qd3x1b	82	17	the	the	DT
cord-252230-s1qd3x1b	82	18	cell	cell	NN
cord-252230-s1qd3x1b	82	19	surface	surface	NN
cord-252230-s1qd3x1b	82	20	,	,	,
cord-252230-s1qd3x1b	82	21	most	most	RBS
cord-252230-s1qd3x1b	82	22	notably	notably	RB
cord-252230-s1qd3x1b	82	23	the	the	DT
cord-252230-s1qd3x1b	82	24	release	release	NN
cord-252230-s1qd3x1b	82	25	of	of	IN
cord-252230-s1qd3x1b	82	26	small	small	JJ
cord-252230-s1qd3x1b	82	27	extracellular	extracellular	JJ
cord-252230-s1qd3x1b	82	28	microvesicles	microvesicle	NNS
cord-252230-s1qd3x1b	82	29	(	(	-LRB-
cord-252230-s1qd3x1b	82	30	exosomes	exosomes	NNP
cord-252230-s1qd3x1b	82	31	)	)	-RRB-
cord-252230-s1qd3x1b	82	32	,	,	,
cord-252230-s1qd3x1b	82	33	a	a	DT
cord-252230-s1qd3x1b	82	34	role	role	NN
cord-252230-s1qd3x1b	82	35	for	for	IN
cord-252230-s1qd3x1b	82	36	the	the	DT
cord-252230-s1qd3x1b	82	37	late	late	JJ
cord-252230-s1qd3x1b	82	38	endocytic	endocytic	JJ
cord-252230-s1qd3x1b	82	39	pathway	pathway	NN
cord-252230-s1qd3x1b	82	40	seems	seem	VBZ
cord-252230-s1qd3x1b	82	41	attractive	attractive	JJ
cord-252230-s1qd3x1b	83	1	(	(	-LRB-
cord-252230-s1qd3x1b	83	2	Colombo	Colombo	NNP
cord-252230-s1qd3x1b	83	3	et	et	NNP
cord-252230-s1qd3x1b	83	4	al	al	NNP
cord-252230-s1qd3x1b	83	5	.	.	NNP
cord-252230-s1qd3x1b	83	6	,	,	,
cord-252230-s1qd3x1b	83	7	2014	2014	CD
cord-252230-s1qd3x1b	83	8	;	;	:
cord-252230-s1qd3x1b	83	9	Fig	Fig	NNP
cord-252230-s1qd3x1b	83	10	.	.	.
cord-252230-s1qd3x1b	83	11	1	1	CD
cord-252230-s1qd3x1b	83	12	B	b	NN
cord-252230-s1qd3x1b	83	13	)	)	-RRB-
cord-252230-s1qd3x1b	83	14	.	.	.
cord-252230-s1qd3x1b	84	1	At	at	IN
cord-252230-s1qd3x1b	84	2	the	the	DT
cord-252230-s1qd3x1b	84	3	same	same	JJ
cord-252230-s1qd3x1b	84	4	time	time	NN
cord-252230-s1qd3x1b	84	5	,	,	,
cord-252230-s1qd3x1b	84	6	recent	recent	JJ
cord-252230-s1qd3x1b	84	7	evidence	evidence	NN
cord-252230-s1qd3x1b	84	8	demonstrates	demonstrate	VBZ
cord-252230-s1qd3x1b	84	9	interconnections	interconnection	NNS
cord-252230-s1qd3x1b	84	10	between	between	IN
cord-252230-s1qd3x1b	84	11	autophagy	autophagy	NN
cord-252230-s1qd3x1b	84	12	and	and	CC
cord-252230-s1qd3x1b	84	13	the	the	DT
cord-252230-s1qd3x1b	84	14	retromer	retromer	NN
cord-252230-s1qd3x1b	84	15	complex	complex	NN
cord-252230-s1qd3x1b	84	16	,	,	,
cord-252230-s1qd3x1b	84	17	a	a	DT
cord-252230-s1qd3x1b	84	18	protein	protein	NN
cord-252230-s1qd3x1b	84	19	assembly	assembly	NN
cord-252230-s1qd3x1b	84	20	implicated	implicate	VBN
cord-252230-s1qd3x1b	84	21	in	in	IN
cord-252230-s1qd3x1b	84	22	plasma	plasma	NN
cord-252230-s1qd3x1b	84	23	membrane	membrane	NN
cord-252230-s1qd3x1b	84	24	exocytosis	exocytosis	NN
cord-252230-s1qd3x1b	84	25	of	of	IN
cord-252230-s1qd3x1b	84	26	diverse	diverse	JJ
cord-252230-s1qd3x1b	84	27	molecules	molecule	NNS
cord-252230-s1qd3x1b	84	28	from	from	IN
cord-252230-s1qd3x1b	84	29	early	early	JJ
cord-252230-s1qd3x1b	84	30	endosomes	endosome	NNS
cord-252230-s1qd3x1b	84	31	(	(	-LRB-
cord-252230-s1qd3x1b	84	32	Steinberg	Steinberg	NNP
cord-252230-s1qd3x1b	84	33	et	et	NNP
cord-252230-s1qd3x1b	84	34	al	al	NNP
cord-252230-s1qd3x1b	84	35	.	.	.
cord-252230-s1qd3x1b	85	1	,	,	,
cord-252230-s1qd3x1b	85	2	2013	2013	CD
cord-252230-s1qd3x1b	85	3	)	)	-RRB-
cord-252230-s1qd3x1b	85	4	.	.	.
cord-252230-s1qd3x1b	86	1	During	during	IN
cord-252230-s1qd3x1b	86	2	metabolic	metabolic	JJ
cord-252230-s1qd3x1b	86	3	stress	stress	NN
cord-252230-s1qd3x1b	86	4	,	,	,
cord-252230-s1qd3x1b	86	5	the	the	DT
cord-252230-s1qd3x1b	86	6	induction	induction	NN
cord-252230-s1qd3x1b	86	7	of	of	IN
cord-252230-s1qd3x1b	86	8	autophagy	autophagy	NN
cord-252230-s1qd3x1b	86	9	elicits	elicit	VBZ
cord-252230-s1qd3x1b	86	10	LC3	lc3	JJ
cord-252230-s1qd3x1b	86	11	+	+	CC
cord-252230-s1qd3x1b	86	12	autophagic	autophagic	NNP
cord-252230-s1qd3x1b	86	13	compartments	compartment	NNS
cord-252230-s1qd3x1b	86	14	that	that	WDT
cord-252230-s1qd3x1b	86	15	bind	bind	VBP
cord-252230-s1qd3x1b	86	16	and	and	CC
cord-252230-s1qd3x1b	86	17	sequester	sequester	VBP
cord-252230-s1qd3x1b	86	18	a	a	DT
cord-252230-s1qd3x1b	86	19	key	key	JJ
cord-252230-s1qd3x1b	86	20	inhibitor	inhibitor	NN
cord-252230-s1qd3x1b	86	21	of	of	IN
cord-252230-s1qd3x1b	86	22	retromer	retromer	NN
cord-252230-s1qd3x1b	86	23	complex	complex	NNP
cord-252230-s1qd3x1b	86	24	,	,	,
cord-252230-s1qd3x1b	86	25	the	the	DT
cord-252230-s1qd3x1b	86	26	RabGAP	rabgap	NN
cord-252230-s1qd3x1b	86	27	protein	protein	NN
cord-252230-s1qd3x1b	86	28	TBC1D5	tbc1d5	CD
cord-252230-s1qd3x1b	86	29	;	;	:
cord-252230-s1qd3x1b	87	1	as	as	IN
cord-252230-s1qd3x1b	87	2	a	a	DT
cord-252230-s1qd3x1b	87	3	result	result	NN
cord-252230-s1qd3x1b	87	4	,	,	,
cord-252230-s1qd3x1b	87	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	87	6	activates	activate	VBZ
cord-252230-s1qd3x1b	87	7	the	the	DT
cord-252230-s1qd3x1b	87	8	retromer	retromer	NN
cord-252230-s1qd3x1b	87	9	-	-	HYPH
cord-252230-s1qd3x1b	87	10	driven	drive	VBN
cord-252230-s1qd3x1b	87	11	translocation	translocation	NN
cord-252230-s1qd3x1b	87	12	of	of	IN
cord-252230-s1qd3x1b	87	13	proteins	protein	NNS
cord-252230-s1qd3x1b	87	14	to	to	IN
cord-252230-s1qd3x1b	87	15	the	the	DT
cord-252230-s1qd3x1b	87	16	plasma	plasma	NN
cord-252230-s1qd3x1b	87	17	membrane	membrane	NN
cord-252230-s1qd3x1b	87	18	surface	surface	NN
cord-252230-s1qd3x1b	87	19	,	,	,
cord-252230-s1qd3x1b	87	20	most	most	RBS
cord-252230-s1qd3x1b	87	21	notably	notably	RB
cord-252230-s1qd3x1b	87	22	the	the	DT
cord-252230-s1qd3x1b	87	23	glucose	glucose	NN
cord-252230-s1qd3x1b	87	24	transporter	transporter	NN
cord-252230-s1qd3x1b	87	25	GLUT1/	glut1/	NN
cord-252230-s1qd3x1b	87	26	SLC2A1	SLC2A1	NNP
cord-252230-s1qd3x1b	88	1	(	(	-LRB-
cord-252230-s1qd3x1b	88	2	Roy	Roy	NNP
cord-252230-s1qd3x1b	88	3	et	et	NNP
cord-252230-s1qd3x1b	88	4	al	al	NNP
cord-252230-s1qd3x1b	88	5	.	.	NNP
cord-252230-s1qd3x1b	88	6	,	,	,
cord-252230-s1qd3x1b	88	7	2017	2017	CD
cord-252230-s1qd3x1b	88	8	)	)	-RRB-
cord-252230-s1qd3x1b	88	9	.	.	.
cord-252230-s1qd3x1b	89	1	Last	last	RB
cord-252230-s1qd3x1b	89	2	,	,	,
cord-252230-s1qd3x1b	89	3	defining	define	VBG
cord-252230-s1qd3x1b	89	4	the	the	DT
cord-252230-s1qd3x1b	89	5	mechanisms	mechanism	NNS
cord-252230-s1qd3x1b	89	6	by	by	IN
cord-252230-s1qd3x1b	89	7	which	which	WDT
cord-252230-s1qd3x1b	89	8	targets	target	NNS
cord-252230-s1qd3x1b	89	9	of	of	IN
cord-252230-s1qd3x1b	89	10	secretory	secretory	JJ
cord-252230-s1qd3x1b	89	11	autophagy	autophagy	NN
cord-252230-s1qd3x1b	89	12	are	be	VBP
cord-252230-s1qd3x1b	89	13	diverted	divert	VBN
cord-252230-s1qd3x1b	89	14	away	away	RB
cord-252230-s1qd3x1b	89	15	from	from	IN
cord-252230-s1qd3x1b	89	16	lysosomal	lysosomal	JJ
cord-252230-s1qd3x1b	89	17	degradation	degradation	NN
cord-252230-s1qd3x1b	89	18	remains	remain	VBZ
cord-252230-s1qd3x1b	89	19	an	an	DT
cord-252230-s1qd3x1b	89	20	important	important	JJ
cord-252230-s1qd3x1b	89	21	question	question	NN
cord-252230-s1qd3x1b	89	22	for	for	IN
cord-252230-s1qd3x1b	89	23	further	further	JJ
cord-252230-s1qd3x1b	89	24	study	study	NN
cord-252230-s1qd3x1b	89	25	.	.	.
cord-252230-s1qd3x1b	90	1	Indeed	indeed	RB
cord-252230-s1qd3x1b	90	2	,	,	,
cord-252230-s1qd3x1b	90	3	recent	recent	JJ
cord-252230-s1qd3x1b	90	4	work	work	NN
cord-252230-s1qd3x1b	90	5	indicates	indicate	VBZ
cord-252230-s1qd3x1b	90	6	that	that	IN
cord-252230-s1qd3x1b	90	7	secretory	secretory	JJ
cord-252230-s1qd3x1b	90	8	autophagy	autophagy	NN
cord-252230-s1qd3x1b	90	9	involves	involve	VBZ
cord-252230-s1qd3x1b	90	10	autophagosome	autophagosome	NN
cord-252230-s1qd3x1b	90	11	-	-	HYPH
cord-252230-s1qd3x1b	90	12	like	like	JJ
cord-252230-s1qd3x1b	90	13	vesicles	vesicle	NNS
cord-252230-s1qd3x1b	90	14	that	that	WDT
cord-252230-s1qd3x1b	90	15	bypass	bypass	VBP
cord-252230-s1qd3x1b	90	16	STX17dependent	STX17dependent	NNP
cord-252230-s1qd3x1b	90	17	fusion	fusion	NN
cord-252230-s1qd3x1b	90	18	with	with	IN
cord-252230-s1qd3x1b	90	19	lysosomes	lysosome	NNS
cord-252230-s1qd3x1b	90	20	;	;	:
cord-252230-s1qd3x1b	90	21	rather	rather	RB
cord-252230-s1qd3x1b	90	22	,	,	,
cord-252230-s1qd3x1b	90	23	they	-PRON-	PRP
cord-252230-s1qd3x1b	90	24	use	use	VBP
cord-252230-s1qd3x1b	90	25	the	the	DT
cord-252230-s1qd3x1b	90	26	SNA	SNA	NNP
cord-252230-s1qd3x1b	90	27	RE	RE	NNP
cord-252230-s1qd3x1b	90	28	protein	protein	NN
cord-252230-s1qd3x1b	90	29	SEC22B	sec22b	NN
cord-252230-s1qd3x1b	90	30	in	in	IN
cord-252230-s1qd3x1b	90	31	combination	combination	NN
cord-252230-s1qd3x1b	90	32	with	with	IN
cord-252230-s1qd3x1b	90	33	plasma	plasma	NN
cord-252230-s1qd3x1b	90	34	membrane	membrane	NN
cord-252230-s1qd3x1b	90	35	syntaxins	syntaxin	NNS
cord-252230-s1qd3x1b	90	36	to	to	TO
cord-252230-s1qd3x1b	90	37	complete	complete	VB
cord-252230-s1qd3x1b	90	38	cargo	cargo	NN
cord-252230-s1qd3x1b	90	39	secretion	secretion	NN
cord-252230-s1qd3x1b	91	1	(	(	-LRB-
cord-252230-s1qd3x1b	91	2	Kimura	Kimura	NNP
cord-252230-s1qd3x1b	91	3	et	et	FW
cord-252230-s1qd3x1b	91	4	al	al	NNP
cord-252230-s1qd3x1b	91	5	.	.	NNP
cord-252230-s1qd3x1b	91	6	,	,	,
cord-252230-s1qd3x1b	91	7	2017	2017	CD
cord-252230-s1qd3x1b	91	8	;	;	:
cord-252230-s1qd3x1b	91	9	Fig	fig	NN
cord-252230-s1qd3x1b	91	10	.	.	.
cord-252230-s1qd3x1b	92	1	1	1	LS
cord-252230-s1qd3x1b	92	2	)	)	-RRB-
cord-252230-s1qd3x1b	92	3	.	.	.
cord-252230-s1qd3x1b	93	1	In	in	IN
cord-252230-s1qd3x1b	93	2	addition	addition	NN
cord-252230-s1qd3x1b	93	3	to	to	IN
cord-252230-s1qd3x1b	93	4	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	93	5	secretion	secretion	NN
cord-252230-s1qd3x1b	93	6	,	,	,
cord-252230-s1qd3x1b	93	7	ATGs	atg	NNS
cord-252230-s1qd3x1b	93	8	promotes	promote	VBZ
cord-252230-s1qd3x1b	93	9	the	the	DT
cord-252230-s1qd3x1b	93	10	efficient	efficient	JJ
cord-252230-s1qd3x1b	93	11	egress	egress	NN
cord-252230-s1qd3x1b	93	12	of	of	IN
cord-252230-s1qd3x1b	93	13	secretory	secretory	JJ
cord-252230-s1qd3x1b	93	14	lysosomes	lysosome	NNS
cord-252230-s1qd3x1b	93	15	in	in	IN
cord-252230-s1qd3x1b	93	16	osteoclasts	osteoclast	NNS
cord-252230-s1qd3x1b	93	17	(	(	-LRB-
cord-252230-s1qd3x1b	93	18	De	De	NNP
cord-252230-s1qd3x1b	93	19	-	-	HYPH
cord-252230-s1qd3x1b	93	20	Selm	Selm	NNP
cord-252230-s1qd3x1b	93	21	et	et	NNP
cord-252230-s1qd3x1b	93	22	al	al	NNP
cord-252230-s1qd3x1b	93	23	.	.	NNP
cord-252230-s1qd3x1b	93	24	,	,	,
cord-252230-s1qd3x1b	93	25	2011	2011	CD
cord-252230-s1qd3x1b	93	26	)	)	-RRB-
cord-252230-s1qd3x1b	93	27	and	and	CC
cord-252230-s1qd3x1b	93	28	the	the	DT
cord-252230-s1qd3x1b	93	29	conventional	conventional	JJ
cord-252230-s1qd3x1b	93	30	secretion	secretion	NN
cord-252230-s1qd3x1b	93	31	of	of	IN
cord-252230-s1qd3x1b	93	32	cytokines	cytokine	NNS
cord-252230-s1qd3x1b	93	33	during	during	IN
cord-252230-s1qd3x1b	93	34	oncogene	oncogene	NN
cord-252230-s1qd3x1b	93	35	-	-	HYPH
cord-252230-s1qd3x1b	93	36	driven	drive	VBN
cord-252230-s1qd3x1b	93	37	cancer	cancer	NN
cord-252230-s1qd3x1b	93	38	cell	cell	NN
cord-252230-s1qd3x1b	93	39	invasion	invasion	NN
cord-252230-s1qd3x1b	93	40	and	and	CC
cord-252230-s1qd3x1b	93	41	senescence	senescence	NN
cord-252230-s1qd3x1b	93	42	(	(	-LRB-
cord-252230-s1qd3x1b	93	43	Narita	Narita	NNP
cord-252230-s1qd3x1b	93	44	et	et	NNP
cord-252230-s1qd3x1b	93	45	al	al	NNP
cord-252230-s1qd3x1b	93	46	.	.	NNP
cord-252230-s1qd3x1b	93	47	,	,	,
cord-252230-s1qd3x1b	93	48	2011	2011	CD
cord-252230-s1qd3x1b	93	49	;	;	:
cord-252230-s1qd3x1b	93	50	Lock	Lock	NNP
cord-252230-s1qd3x1b	93	51	et	et	FW
cord-252230-s1qd3x1b	93	52	al	al	NNP
cord-252230-s1qd3x1b	93	53	.	.	NNP
cord-252230-s1qd3x1b	93	54	,	,	,
cord-252230-s1qd3x1b	93	55	2014	2014	CD
cord-252230-s1qd3x1b	93	56	)	)	-RRB-
cord-252230-s1qd3x1b	93	57	.	.	.
cord-252230-s1qd3x1b	94	1	Further	further	RB
cord-252230-s1qd3x1b	94	2	dissecting	dissect	VBG
cord-252230-s1qd3x1b	94	3	the	the	DT
cord-252230-s1qd3x1b	94	4	cellular	cellular	JJ
cord-252230-s1qd3x1b	94	5	mechanisms	mechanism	NNS
cord-252230-s1qd3x1b	94	6	through	through	IN
cord-252230-s1qd3x1b	94	7	which	which	WDT
cord-252230-s1qd3x1b	94	8	autophagy	autophagy	NN
cord-252230-s1qd3x1b	94	9	mediators	mediator	NNS
cord-252230-s1qd3x1b	94	10	facilitate	facilitate	VBP
cord-252230-s1qd3x1b	94	11	these	these	DT
cord-252230-s1qd3x1b	94	12	diverse	diverse	JJ
cord-252230-s1qd3x1b	94	13	secretory	secretory	JJ
cord-252230-s1qd3x1b	94	14	processes	process	NNS
cord-252230-s1qd3x1b	94	15	remains	remain	VBZ
cord-252230-s1qd3x1b	94	16	an	an	DT
cord-252230-s1qd3x1b	94	17	important	important	JJ
cord-252230-s1qd3x1b	94	18	topic	topic	NN
cord-252230-s1qd3x1b	94	19	for	for	IN
cord-252230-s1qd3x1b	94	20	future	future	JJ
cord-252230-s1qd3x1b	94	21	study	study	NN
cord-252230-s1qd3x1b	94	22	.	.	.
cord-252230-s1qd3x1b	95	1	Studies	study	NNS
cord-252230-s1qd3x1b	95	2	of	of	IN
cord-252230-s1qd3x1b	95	3	LAP	LAP	NNP
cord-252230-s1qd3x1b	95	4	poignantly	poignantly	RB
cord-252230-s1qd3x1b	95	5	illustrate	illustrate	VBP
cord-252230-s1qd3x1b	95	6	how	how	WRB
cord-252230-s1qd3x1b	95	7	key	key	JJ
cord-252230-s1qd3x1b	95	8	elements	element	NNS
cord-252230-s1qd3x1b	95	9	of	of	IN
cord-252230-s1qd3x1b	95	10	the	the	DT
cord-252230-s1qd3x1b	95	11	core	core	NN
cord-252230-s1qd3x1b	95	12	autophagy	autophagy	NN
cord-252230-s1qd3x1b	95	13	machinery	machinery	NN
cord-252230-s1qd3x1b	95	14	can	can	MD
cord-252230-s1qd3x1b	95	15	be	be	VB
cord-252230-s1qd3x1b	95	16	redirected	redirect	VBN
cord-252230-s1qd3x1b	95	17	toward	toward	IN
cord-252230-s1qd3x1b	95	18	lysosomal	lysosomal	JJ
cord-252230-s1qd3x1b	95	19	pathways	pathway	NNS
cord-252230-s1qd3x1b	95	20	that	that	WDT
cord-252230-s1qd3x1b	95	21	are	be	VBP
cord-252230-s1qd3x1b	95	22	distinct	distinct	JJ
cord-252230-s1qd3x1b	95	23	from	from	IN
cord-252230-s1qd3x1b	95	24	the	the	DT
cord-252230-s1qd3x1b	95	25	canonical	canonical	JJ
cord-252230-s1qd3x1b	95	26	autophagosome	autophagosome	NN
cord-252230-s1qd3x1b	95	27	-	-	HYPH
cord-252230-s1qd3x1b	95	28	to	to	IN
cord-252230-s1qd3x1b	95	29	-	-	HYPH
cord-252230-s1qd3x1b	95	30	lysosome	lysosome	NN
cord-252230-s1qd3x1b	95	31	cascade	cascade	NN
cord-252230-s1qd3x1b	95	32	.	.	.
cord-252230-s1qd3x1b	96	1	LAP	lap	NN
cord-252230-s1qd3x1b	96	2	represents	represent	VBZ
cord-252230-s1qd3x1b	96	3	a	a	DT
cord-252230-s1qd3x1b	96	4	process	process	NN
cord-252230-s1qd3x1b	96	5	akin	akin	JJ
cord-252230-s1qd3x1b	96	6	to	to	IN
cord-252230-s1qd3x1b	96	7	macroautophagy	macroautophagy	NNS
cord-252230-s1qd3x1b	96	8	in	in	IN
cord-252230-s1qd3x1b	96	9	which	which	WDT
cord-252230-s1qd3x1b	96	10	phagosomes	phagosomes	NNP
cord-252230-s1qd3x1b	96	11	engulf	engulf	VBP
cord-252230-s1qd3x1b	96	12	extracellular	extracellular	JJ
cord-252230-s1qd3x1b	96	13	contents	content	NNS
cord-252230-s1qd3x1b	96	14	,	,	,
cord-252230-s1qd3x1b	96	15	such	such	JJ
cord-252230-s1qd3x1b	96	16	as	as	IN
cord-252230-s1qd3x1b	96	17	microorganisms	microorganism	NNS
cord-252230-s1qd3x1b	96	18	or	or	CC
cord-252230-s1qd3x1b	96	19	dying	die	VBG
cord-252230-s1qd3x1b	96	20	cells	cell	NNS
cord-252230-s1qd3x1b	96	21	,	,	,
cord-252230-s1qd3x1b	96	22	which	which	WDT
cord-252230-s1qd3x1b	96	23	are	be	VBP
cord-252230-s1qd3x1b	96	24	subsequently	subsequently	RB
cord-252230-s1qd3x1b	96	25	trafficked	traffic	VBN
cord-252230-s1qd3x1b	96	26	to	to	IN
cord-252230-s1qd3x1b	96	27	the	the	DT
cord-252230-s1qd3x1b	96	28	lysosome	lysosome	NN
cord-252230-s1qd3x1b	96	29	(	(	-LRB-
cord-252230-s1qd3x1b	96	30	Sanjuan	Sanjuan	NNP
cord-252230-s1qd3x1b	96	31	et	et	NNP
cord-252230-s1qd3x1b	96	32	al	al	NNP
cord-252230-s1qd3x1b	96	33	.	.	NNP
cord-252230-s1qd3x1b	96	34	,	,	,
cord-252230-s1qd3x1b	96	35	2007	2007	CD
cord-252230-s1qd3x1b	96	36	)	)	-RRB-
cord-252230-s1qd3x1b	96	37	.	.	.
cord-252230-s1qd3x1b	97	1	During	during	IN
cord-252230-s1qd3x1b	97	2	LAP	lap	NN
cord-252230-s1qd3x1b	97	3	,	,	,
cord-252230-s1qd3x1b	97	4	elements	element	NNS
cord-252230-s1qd3x1b	97	5	of	of	IN
cord-252230-s1qd3x1b	97	6	the	the	DT
cord-252230-s1qd3x1b	97	7	autophagy	autophagy	NN
cord-252230-s1qd3x1b	97	8	machinery	machinery	NN
cord-252230-s1qd3x1b	97	9	are	be	VBP
cord-252230-s1qd3x1b	97	10	recruited	recruit	VBN
cord-252230-s1qd3x1b	97	11	to	to	IN
cord-252230-s1qd3x1b	97	12	phagosomes	phagosomes	NNP
cord-252230-s1qd3x1b	97	13	,	,	,
cord-252230-s1qd3x1b	97	14	upon	upon	IN
cord-252230-s1qd3x1b	97	15	which	which	WDT
cord-252230-s1qd3x1b	97	16	they	-PRON-	PRP
cord-252230-s1qd3x1b	97	17	facilitate	facilitate	VBP
cord-252230-s1qd3x1b	97	18	maturation	maturation	NN
cord-252230-s1qd3x1b	97	19	and	and	CC
cord-252230-s1qd3x1b	97	20	the	the	DT
cord-252230-s1qd3x1b	97	21	digestion	digestion	NN
cord-252230-s1qd3x1b	97	22	of	of	IN
cord-252230-s1qd3x1b	97	23	phagosomal	phagosomal	NN
cord-252230-s1qd3x1b	97	24	contents	content	NNS
cord-252230-s1qd3x1b	97	25	(	(	-LRB-
cord-252230-s1qd3x1b	97	26	Fig	Fig	NNP
cord-252230-s1qd3x1b	97	27	.	.	.
cord-252230-s1qd3x1b	97	28	1	1	CD
cord-252230-s1qd3x1b	97	29	C	C	NNP
cord-252230-s1qd3x1b	97	30	)	)	-RRB-
cord-252230-s1qd3x1b	97	31	.	.	.
cord-252230-s1qd3x1b	98	1	Originally	originally	RB
cord-252230-s1qd3x1b	98	2	discovered	discover	VBN
cord-252230-s1qd3x1b	98	3	during	during	IN
cord-252230-s1qd3x1b	98	4	phagocytosis	phagocytosis	NN
cord-252230-s1qd3x1b	98	5	of	of	IN
cord-252230-s1qd3x1b	98	6	particles	particle	NNS
cord-252230-s1qd3x1b	98	7	containing	contain	VBG
cord-252230-s1qd3x1b	98	8	Toll	Toll	NNP
cord-252230-s1qd3x1b	98	9	-	-	HYPH
cord-252230-s1qd3x1b	98	10	like	like	JJ
cord-252230-s1qd3x1b	98	11	receptor	receptor	NN
cord-252230-s1qd3x1b	98	12	(	(	-LRB-
cord-252230-s1qd3x1b	98	13	TLR	TLR	NNP
cord-252230-s1qd3x1b	98	14	)	)	-RRB-
cord-252230-s1qd3x1b	98	15	ligands	ligand	NNS
cord-252230-s1qd3x1b	98	16	,	,	,
cord-252230-s1qd3x1b	98	17	LAP	lap	NN
cord-252230-s1qd3x1b	98	18	involves	involve	VBZ
cord-252230-s1qd3x1b	98	19	the	the	DT
cord-252230-s1qd3x1b	98	20	recruitment	recruitment	NN
cord-252230-s1qd3x1b	98	21	of	of	IN
cord-252230-s1qd3x1b	98	22	the	the	DT
cord-252230-s1qd3x1b	98	23	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	99	1	(	(	-LRB-
cord-252230-s1qd3x1b	99	2	BECN1)-VPS34	BECN1)-VPS34	NNP
cord-252230-s1qd3x1b	99	3	complex	complex	JJ
cord-252230-s1qd3x1b	99	4	to	to	IN
cord-252230-s1qd3x1b	99	5	the	the	DT
cord-252230-s1qd3x1b	99	6	phagosome	phagosome	NN
cord-252230-s1qd3x1b	99	7	,	,	,
cord-252230-s1qd3x1b	99	8	resulting	result	VBG
cord-252230-s1qd3x1b	99	9	in	in	IN
cord-252230-s1qd3x1b	99	10	production	production	NN
cord-252230-s1qd3x1b	99	11	of	of	IN
cord-252230-s1qd3x1b	99	12	phosphatidylinositol	phosphatidylinositol	JJ
cord-252230-s1qd3x1b	99	13	3-phosphate	3-phosphate	CD
cord-252230-s1qd3x1b	99	14	and	and	CC
cord-252230-s1qd3x1b	99	15	the	the	DT
cord-252230-s1qd3x1b	99	16	subsequent	subsequent	JJ
cord-252230-s1qd3x1b	99	17	formation	formation	NN
cord-252230-s1qd3x1b	99	18	of	of	IN
cord-252230-s1qd3x1b	99	19	phosphatidylethanolamine	phosphatidylethanolamine	JJ
cord-252230-s1qd3x1b	99	20	lipidated	lipidate	VBN
cord-252230-s1qd3x1b	99	21	,	,	,
cord-252230-s1qd3x1b	99	22	membrane	membrane	NN
cord-252230-s1qd3x1b	99	23	-	-	HYPH
cord-252230-s1qd3x1b	99	24	bound	bind	VBN
cord-252230-s1qd3x1b	99	25	LC3	lc3	NN
cord-252230-s1qd3x1b	99	26	(	(	-LRB-
cord-252230-s1qd3x1b	99	27	LC3-II	lc3-ii	NN
cord-252230-s1qd3x1b	99	28	;	;	:
cord-252230-s1qd3x1b	99	29	(	(	-LRB-
cord-252230-s1qd3x1b	99	30	Sanjuan	Sanjuan	NNP
cord-252230-s1qd3x1b	99	31	et	et	NNP
cord-252230-s1qd3x1b	99	32	al	al	NNP
cord-252230-s1qd3x1b	99	33	.	.	NNP
cord-252230-s1qd3x1b	99	34	,	,	,
cord-252230-s1qd3x1b	99	35	2007	2007	CD
cord-252230-s1qd3x1b	99	36	)	)	-RRB-
cord-252230-s1qd3x1b	99	37	.	.	.
cord-252230-s1qd3x1b	100	1	LC3-II	LC3-II	NNP
cord-252230-s1qd3x1b	100	2	facilitates	facilitate	VBZ
cord-252230-s1qd3x1b	100	3	phagosome	phagosome	NN
cord-252230-s1qd3x1b	100	4	maturation	maturation	NN
cord-252230-s1qd3x1b	100	5	in	in	IN
cord-252230-s1qd3x1b	100	6	LAP	lap	NN
cord-252230-s1qd3x1b	100	7	,	,	,
cord-252230-s1qd3x1b	100	8	probably	probably	RB
cord-252230-s1qd3x1b	100	9	by	by	IN
cord-252230-s1qd3x1b	100	10	recruiting	recruit	VBG
cord-252230-s1qd3x1b	100	11	molecules	molecule	NNS
cord-252230-s1qd3x1b	100	12	that	that	WDT
cord-252230-s1qd3x1b	100	13	enhances	enhance	VBZ
cord-252230-s1qd3x1b	100	14	fusion	fusion	NN
cord-252230-s1qd3x1b	100	15	to	to	IN
cord-252230-s1qd3x1b	100	16	the	the	DT
cord-252230-s1qd3x1b	100	17	endolysosomal	endolysosomal	NNP
cord-252230-s1qd3x1b	100	18	compartment	compartment	NN
cord-252230-s1qd3x1b	100	19	,	,	,
cord-252230-s1qd3x1b	100	20	such	such	JJ
cord-252230-s1qd3x1b	100	21	as	as	IN
cord-252230-s1qd3x1b	100	22	the	the	DT
cord-252230-s1qd3x1b	100	23	homotypic	homotypic	JJ
cord-252230-s1qd3x1b	100	24	fusion	fusion	NN
cord-252230-s1qd3x1b	100	25	and	and	CC
cord-252230-s1qd3x1b	100	26	protein	protein	NN
cord-252230-s1qd3x1b	100	27	sorting	sorting	NN
cord-252230-s1qd3x1b	100	28	complex	complex	NN
cord-252230-s1qd3x1b	100	29	involved	involve	VBN
cord-252230-s1qd3x1b	100	30	in	in	IN
cord-252230-s1qd3x1b	100	31	Rab7-mediated	rab7-mediated	JJ
cord-252230-s1qd3x1b	100	32	lysosomal	lysosomal	JJ
cord-252230-s1qd3x1b	100	33	fusion	fusion	NN
cord-252230-s1qd3x1b	100	34	(	(	-LRB-
cord-252230-s1qd3x1b	100	35	McEwan	McEwan	NNP
cord-252230-s1qd3x1b	100	36	et	et	NNP
cord-252230-s1qd3x1b	100	37	al	al	NNP
cord-252230-s1qd3x1b	100	38	.	.	NNP
cord-252230-s1qd3x1b	100	39	,	,	,
cord-252230-s1qd3x1b	100	40	2015	2015	CD
cord-252230-s1qd3x1b	100	41	)	)	-RRB-
cord-252230-s1qd3x1b	100	42	.	.	.
cord-252230-s1qd3x1b	101	1	In	in	IN
cord-252230-s1qd3x1b	101	2	addition	addition	NN
cord-252230-s1qd3x1b	101	3	to	to	IN
cord-252230-s1qd3x1b	101	4	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	101	5	,	,	,
cord-252230-s1qd3x1b	101	6	multiple	multiple	JJ
cord-252230-s1qd3x1b	101	7	ATGs	atg	NNS
cord-252230-s1qd3x1b	101	8	are	be	VBP
cord-252230-s1qd3x1b	101	9	required	require	VBN
cord-252230-s1qd3x1b	101	10	for	for	IN
cord-252230-s1qd3x1b	101	11	LAP	lap	NN
cord-252230-s1qd3x1b	101	12	,	,	,
cord-252230-s1qd3x1b	101	13	including	include	VBG
cord-252230-s1qd3x1b	101	14	all	all	DT
cord-252230-s1qd3x1b	101	15	key	key	JJ
cord-252230-s1qd3x1b	101	16	elements	element	NNS
cord-252230-s1qd3x1b	101	17	of	of	IN
cord-252230-s1qd3x1b	101	18	the	the	DT
cord-252230-s1qd3x1b	101	19	LC3	lc3	JJ
cord-252230-s1qd3x1b	101	20	conjugation	conjugation	NN
cord-252230-s1qd3x1b	101	21	machinery	machinery	NN
cord-252230-s1qd3x1b	101	22	(	(	-LRB-
cord-252230-s1qd3x1b	101	23	ATG3	ATG3	NNP
cord-252230-s1qd3x1b	101	24	,	,	,
cord-252230-s1qd3x1b	101	25	ATG5	ATG5	NNP
cord-252230-s1qd3x1b	101	26	,	,	,
cord-252230-s1qd3x1b	101	27	ATG7	ATG7	NNP
cord-252230-s1qd3x1b	101	28	,	,	,
cord-252230-s1qd3x1b	101	29	ATG12	ATG12	NNP
cord-252230-s1qd3x1b	101	30	,	,	,
cord-252230-s1qd3x1b	101	31	and	and	CC
cord-252230-s1qd3x1b	101	32	ATG16L	atg16l	NN
cord-252230-s1qd3x1b	101	33	;	;	:
cord-252230-s1qd3x1b	101	34	Martinez	Martinez	NNP
cord-252230-s1qd3x1b	101	35	et	et	NNP
cord-252230-s1qd3x1b	101	36	al	al	NNP
cord-252230-s1qd3x1b	101	37	.	.	NNP
cord-252230-s1qd3x1b	101	38	,	,	,
cord-252230-s1qd3x1b	101	39	2011	2011	CD
cord-252230-s1qd3x1b	101	40	)	)	-RRB-
cord-252230-s1qd3x1b	101	41	.	.	.
cord-252230-s1qd3x1b	102	1	Despite	despite	IN
cord-252230-s1qd3x1b	102	2	this	this	DT
cord-252230-s1qd3x1b	102	3	common	common	JJ
cord-252230-s1qd3x1b	102	4	utilization	utilization	NN
cord-252230-s1qd3x1b	102	5	of	of	IN
cord-252230-s1qd3x1b	102	6	multiple	multiple	JJ
cord-252230-s1qd3x1b	102	7	ATGs	atg	NNS
cord-252230-s1qd3x1b	102	8	,	,	,
cord-252230-s1qd3x1b	102	9	LAP	lap	NN
cord-252230-s1qd3x1b	102	10	is	be	VBZ
cord-252230-s1qd3x1b	102	11	a	a	DT
cord-252230-s1qd3x1b	102	12	mechanistically	mechanistically	RB
cord-252230-s1qd3x1b	102	13	distinct	distinct	JJ
cord-252230-s1qd3x1b	102	14	process	process	NN
cord-252230-s1qd3x1b	102	15	.	.	.
cord-252230-s1qd3x1b	103	1	During	during	IN
cord-252230-s1qd3x1b	103	2	classic	classic	JJ
cord-252230-s1qd3x1b	103	3	autophagy	autophagy	NN
cord-252230-s1qd3x1b	103	4	,	,	,
cord-252230-s1qd3x1b	103	5	LC3	LC3	NNP
cord-252230-s1qd3x1b	103	6	lipidation	lipidation	NN
cord-252230-s1qd3x1b	103	7	occurs	occur	VBZ
cord-252230-s1qd3x1b	103	8	on	on	IN
cord-252230-s1qd3x1b	103	9	early	early	JJ
cord-252230-s1qd3x1b	103	10	double	double	JJ
cord-252230-s1qd3x1b	103	11	membrane	membrane	NN
cord-252230-s1qd3x1b	103	12	structures	structure	NNS
cord-252230-s1qd3x1b	103	13	,	,	,
cord-252230-s1qd3x1b	103	14	called	call	VBN
cord-252230-s1qd3x1b	103	15	phagophores	phagophores	NNP
cord-252230-s1qd3x1b	103	16	,	,	,
cord-252230-s1qd3x1b	103	17	and	and	CC
cord-252230-s1qd3x1b	103	18	functions	function	NNS
cord-252230-s1qd3x1b	103	19	in	in	IN
cord-252230-s1qd3x1b	103	20	the	the	DT
cord-252230-s1qd3x1b	103	21	capture	capture	NN
cord-252230-s1qd3x1b	103	22	of	of	IN
cord-252230-s1qd3x1b	103	23	autophagic	autophagic	NNP
cord-252230-s1qd3x1b	103	24	cargo	cargo	NN
cord-252230-s1qd3x1b	103	25	and	and	CC
cord-252230-s1qd3x1b	103	26	to	to	TO
cord-252230-s1qd3x1b	103	27	enhance	enhance	VB
cord-252230-s1qd3x1b	103	28	the	the	DT
cord-252230-s1qd3x1b	103	29	stability	stability	NN
cord-252230-s1qd3x1b	103	30	of	of	IN
cord-252230-s1qd3x1b	103	31	the	the	DT
cord-252230-s1qd3x1b	103	32	inner	inner	JJ
cord-252230-s1qd3x1b	103	33	autophagosomal	autophagosomal	NN
cord-252230-s1qd3x1b	103	34	membrane	membrane	NN
cord-252230-s1qd3x1b	103	35	(	(	-LRB-
cord-252230-s1qd3x1b	103	36	Stolz	Stolz	NNP
cord-252230-s1qd3x1b	103	37	et	et	NNP
cord-252230-s1qd3x1b	103	38	al	al	NNP
cord-252230-s1qd3x1b	103	39	.	.	NNP
cord-252230-s1qd3x1b	103	40	,	,	,
cord-252230-s1qd3x1b	103	41	2014	2014	CD
cord-252230-s1qd3x1b	103	42	;	;	:
cord-252230-s1qd3x1b	103	43	Tsuboyama	Tsuboyama	NNP
cord-252230-s1qd3x1b	103	44	et	et	NNP
cord-252230-s1qd3x1b	103	45	al	al	NNP
cord-252230-s1qd3x1b	103	46	.	.	NNP
cord-252230-s1qd3x1b	103	47	,	,	,
cord-252230-s1qd3x1b	103	48	2016	2016	CD
cord-252230-s1qd3x1b	103	49	)	)	-RRB-
cord-252230-s1qd3x1b	103	50	.	.	.
cord-252230-s1qd3x1b	104	1	In	in	IN
cord-252230-s1qd3x1b	104	2	contrast	contrast	NN
cord-252230-s1qd3x1b	104	3	,	,	,
cord-252230-s1qd3x1b	104	4	during	during	IN
cord-252230-s1qd3x1b	104	5	LAP	lap	NN
cord-252230-s1qd3x1b	104	6	,	,	,
cord-252230-s1qd3x1b	104	7	components	component	NNS
cord-252230-s1qd3x1b	104	8	of	of	IN
cord-252230-s1qd3x1b	104	9	the	the	DT
cord-252230-s1qd3x1b	104	10	autophagy	autophagy	NN
cord-252230-s1qd3x1b	104	11	conjugation	conjugation	NN
cord-252230-s1qd3x1b	104	12	machinery	machinery	NN
cord-252230-s1qd3x1b	104	13	recruit	recruit	VBP
cord-252230-s1qd3x1b	104	14	LC3-II	LC3-II	NNP
cord-252230-s1qd3x1b	104	15	directly	directly	RB
cord-252230-s1qd3x1b	104	16	onto	onto	IN
cord-252230-s1qd3x1b	104	17	phagosomes	phagosomes	NNP
cord-252230-s1qd3x1b	104	18	,	,	,
cord-252230-s1qd3x1b	104	19	which	which	WDT
cord-252230-s1qd3x1b	104	20	are	be	VBP
cord-252230-s1qd3x1b	104	21	single	single	JJ
cord-252230-s1qd3x1b	104	22	membrane	membrane	NN
cord-252230-s1qd3x1b	104	23	organelles	organelle	NNS
cord-252230-s1qd3x1b	104	24	.	.	.
cord-252230-s1qd3x1b	105	1	As	as	IN
cord-252230-s1qd3x1b	105	2	a	a	DT
cord-252230-s1qd3x1b	105	3	result	result	NN
cord-252230-s1qd3x1b	105	4	,	,	,
cord-252230-s1qd3x1b	105	5	LAP	lap	NN
cord-252230-s1qd3x1b	105	6	does	do	VBZ
cord-252230-s1qd3x1b	105	7	not	not	RB
cord-252230-s1qd3x1b	105	8	use	use	VB
cord-252230-s1qd3x1b	105	9	the	the	DT
cord-252230-s1qd3x1b	105	10	ULK	ULK	NNP
cord-252230-s1qd3x1b	105	11	(	(	-LRB-
cord-252230-s1qd3x1b	105	12	unc-51-like	unc-51-like	IN
cord-252230-s1qd3x1b	105	13	autophagy	autophagy	NN
cord-252230-s1qd3x1b	105	14	activating	activate	VBG
cord-252230-s1qd3x1b	105	15	kinase	kinase	NN
cord-252230-s1qd3x1b	105	16	)	)	-RRB-
cord-252230-s1qd3x1b	105	17	complex	complex	NN
cord-252230-s1qd3x1b	105	18	that	that	WDT
cord-252230-s1qd3x1b	105	19	initiates	initiate	VBZ
cord-252230-s1qd3x1b	105	20	canonical	canonical	JJ
cord-252230-s1qd3x1b	105	21	autophagy	autophagy	NN
cord-252230-s1qd3x1b	106	1	(	(	-LRB-
cord-252230-s1qd3x1b	106	2	Martinez	Martinez	NNP
cord-252230-s1qd3x1b	106	3	et	et	NNP
cord-252230-s1qd3x1b	106	4	al	al	NNP
cord-252230-s1qd3x1b	106	5	.	.	.
cord-252230-s1qd3x1b	107	1	,	,	,
cord-252230-s1qd3x1b	107	2	2011	2011	CD
cord-252230-s1qd3x1b	107	3	)	)	-RRB-
cord-252230-s1qd3x1b	107	4	.	.	.
cord-252230-s1qd3x1b	108	1	Notably	notably	RB
cord-252230-s1qd3x1b	108	2	,	,	,
cord-252230-s1qd3x1b	108	3	similar	similar	JJ
cord-252230-s1qd3x1b	108	4	pathways	pathway	NNS
cord-252230-s1qd3x1b	108	5	direct	direct	JJ
cord-252230-s1qd3x1b	108	6	LC3	lc3	JJ
cord-252230-s1qd3x1b	108	7	conjugation	conjugation	NN
cord-252230-s1qd3x1b	108	8	onto	onto	IN
cord-252230-s1qd3x1b	108	9	single	single	JJ
cord-252230-s1qd3x1b	108	10	-	-	HYPH
cord-252230-s1qd3x1b	108	11	membrane	membrane	NN
cord-252230-s1qd3x1b	108	12	organelles	organelle	NNS
cord-252230-s1qd3x1b	108	13	during	during	IN
cord-252230-s1qd3x1b	108	14	entosis	entosis	NNP
cord-252230-s1qd3x1b	108	15	and	and	CC
cord-252230-s1qd3x1b	108	16	macropinocytosis	macropinocytosis	NNP
cord-252230-s1qd3x1b	108	17	,	,	,
cord-252230-s1qd3x1b	108	18	two	two	CD
cord-252230-s1qd3x1b	108	19	processes	process	NNS
cord-252230-s1qd3x1b	108	20	that	that	WDT
cord-252230-s1qd3x1b	108	21	also	also	RB
cord-252230-s1qd3x1b	108	22	converge	converge	VBP
cord-252230-s1qd3x1b	108	23	on	on	IN
cord-252230-s1qd3x1b	108	24	the	the	DT
cord-252230-s1qd3x1b	108	25	lysosome	lysosome	NN
cord-252230-s1qd3x1b	108	26	(	(	-LRB-
cord-252230-s1qd3x1b	108	27	Florey	Florey	NNP
cord-252230-s1qd3x1b	108	28	et	et	NNP
cord-252230-s1qd3x1b	108	29	al	al	NNP
cord-252230-s1qd3x1b	108	30	.	.	NNP
cord-252230-s1qd3x1b	108	31	,	,	,
cord-252230-s1qd3x1b	108	32	2011	2011	CD
cord-252230-s1qd3x1b	108	33	)	)	-RRB-
cord-252230-s1qd3x1b	108	34	.	.	.
cord-252230-s1qd3x1b	109	1	Furthermore	furthermore	RB
cord-252230-s1qd3x1b	109	2	,	,	,
cord-252230-s1qd3x1b	109	3	LAP	lap	NN
cord-252230-s1qd3x1b	109	4	uses	use	VBZ
cord-252230-s1qd3x1b	109	5	a	a	DT
cord-252230-s1qd3x1b	109	6	unique	unique	JJ
cord-252230-s1qd3x1b	109	7	VPS34	VPS34	NNP
cord-252230-s1qd3x1b	109	8	complex	complex	NN
cord-252230-s1qd3x1b	109	9	,	,	,
cord-252230-s1qd3x1b	109	10	composed	compose	VBN
cord-252230-s1qd3x1b	109	11	of	of	IN
cord-252230-s1qd3x1b	109	12	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	109	13	,	,	,
cord-252230-s1qd3x1b	109	14	UVR	UVR	NNP
cord-252230-s1qd3x1b	109	15	AG	AG	NNP
cord-252230-s1qd3x1b	109	16	,	,	,
cord-252230-s1qd3x1b	109	17	and	and	CC
cord-252230-s1qd3x1b	109	18	Rubicon	Rubicon	NNP
cord-252230-s1qd3x1b	109	19	(	(	-LRB-
cord-252230-s1qd3x1b	109	20	RUB	RUB	NNP
cord-252230-s1qd3x1b	109	21	CN	CN	NNP
cord-252230-s1qd3x1b	109	22	)	)	-RRB-
cord-252230-s1qd3x1b	109	23	,	,	,
cord-252230-s1qd3x1b	109	24	a	a	DT
cord-252230-s1qd3x1b	109	25	protein	protein	NN
cord-252230-s1qd3x1b	109	26	that	that	WDT
cord-252230-s1qd3x1b	109	27	is	be	VBZ
cord-252230-s1qd3x1b	109	28	inhibitory	inhibitory	JJ
cord-252230-s1qd3x1b	109	29	to	to	IN
cord-252230-s1qd3x1b	109	30	classic	classic	JJ
cord-252230-s1qd3x1b	109	31	autophagy	autophagy	NN
cord-252230-s1qd3x1b	110	1	(	(	-LRB-
cord-252230-s1qd3x1b	110	2	Martinez	Martinez	NNP
cord-252230-s1qd3x1b	110	3	et	et	NNP
cord-252230-s1qd3x1b	110	4	al	al	NNP
cord-252230-s1qd3x1b	110	5	.	.	NNP
cord-252230-s1qd3x1b	110	6	,	,	,
cord-252230-s1qd3x1b	110	7	2015	2015	CD
cord-252230-s1qd3x1b	110	8	)	)	-RRB-
cord-252230-s1qd3x1b	110	9	.	.	.
cord-252230-s1qd3x1b	111	1	Last	last	RB
cord-252230-s1qd3x1b	111	2	,	,	,
cord-252230-s1qd3x1b	111	3	generation	generation	NN
cord-252230-s1qd3x1b	111	4	of	of	IN
cord-252230-s1qd3x1b	111	5	reactive	reactive	JJ
cord-252230-s1qd3x1b	111	6	oxygen	oxygen	NN
cord-252230-s1qd3x1b	111	7	species	specie	NNS
cord-252230-s1qd3x1b	111	8	(	(	-LRB-
cord-252230-s1qd3x1b	111	9	ROS	ROS	NNP
cord-252230-s1qd3x1b	111	10	)	)	-RRB-
cord-252230-s1qd3x1b	111	11	by	by	IN
cord-252230-s1qd3x1b	111	12	NAD	NAD	NNP
cord-252230-s1qd3x1b	111	13	PH	PH	NNP
cord-252230-s1qd3x1b	111	14	oxidase-2	oxidase-2	NNP
cord-252230-s1qd3x1b	111	15	(	(	-LRB-
cord-252230-s1qd3x1b	111	16	NOX2	NOX2	NNP
cord-252230-s1qd3x1b	111	17	)	)	-RRB-
cord-252230-s1qd3x1b	111	18	has	have	VBZ
cord-252230-s1qd3x1b	111	19	also	also	RB
cord-252230-s1qd3x1b	111	20	been	be	VBN
cord-252230-s1qd3x1b	111	21	critically	critically	RB
cord-252230-s1qd3x1b	111	22	implicated	implicate	VBN
cord-252230-s1qd3x1b	111	23	in	in	IN
cord-252230-s1qd3x1b	111	24	the	the	DT
cord-252230-s1qd3x1b	111	25	control	control	NN
cord-252230-s1qd3x1b	111	26	of	of	IN
cord-252230-s1qd3x1b	111	27	LAP	LAP	NNP
cord-252230-s1qd3x1b	111	28	(	(	-LRB-
cord-252230-s1qd3x1b	111	29	Martinez	Martinez	NNP
cord-252230-s1qd3x1b	111	30	et	et	NNP
cord-252230-s1qd3x1b	111	31	al	al	NNP
cord-252230-s1qd3x1b	111	32	.	.	NNP
cord-252230-s1qd3x1b	111	33	,	,	,
cord-252230-s1qd3x1b	111	34	2015	2015	CD
cord-252230-s1qd3x1b	111	35	)	)	-RRB-
cord-252230-s1qd3x1b	111	36	.	.	.
cord-252230-s1qd3x1b	112	1	LAP	lap	NN
cord-252230-s1qd3x1b	112	2	serves	serve	VBZ
cord-252230-s1qd3x1b	112	3	as	as	IN
cord-252230-s1qd3x1b	112	4	a	a	DT
cord-252230-s1qd3x1b	112	5	host	host	NN
cord-252230-s1qd3x1b	112	6	defense	defense	NN
cord-252230-s1qd3x1b	112	7	system	system	NN
cord-252230-s1qd3x1b	112	8	targeting	target	VBG
cord-252230-s1qd3x1b	112	9	several	several	JJ
cord-252230-s1qd3x1b	112	10	pathogens	pathogen	NNS
cord-252230-s1qd3x1b	112	11	,	,	,
cord-252230-s1qd3x1b	112	12	including	include	VBG
cord-252230-s1qd3x1b	112	13	Aspergillus	aspergillus	NN
cord-252230-s1qd3x1b	112	14	fumigatus	fumigatus	NN
cord-252230-s1qd3x1b	112	15	and	and	CC
cord-252230-s1qd3x1b	112	16	Salmonella	Salmonella	NNP
cord-252230-s1qd3x1b	112	17	typhimurium	typhimurium	NNP
cord-252230-s1qd3x1b	113	1	(	(	-LRB-
cord-252230-s1qd3x1b	113	2	Huang	Huang	NNP
cord-252230-s1qd3x1b	113	3	et	et	NNP
cord-252230-s1qd3x1b	113	4	al	al	NNP
cord-252230-s1qd3x1b	113	5	.	.	.
cord-252230-s1qd3x1b	114	1	,	,	,
cord-252230-s1qd3x1b	114	2	2009	2009	CD
cord-252230-s1qd3x1b	114	3	;	;	:
cord-252230-s1qd3x1b	114	4	Martinez	Martinez	NNP
cord-252230-s1qd3x1b	114	5	et	et	NNP
cord-252230-s1qd3x1b	114	6	al	al	NNP
cord-252230-s1qd3x1b	114	7	.	.	NNP
cord-252230-s1qd3x1b	114	8	,	,	,
cord-252230-s1qd3x1b	114	9	2015	2015	CD
cord-252230-s1qd3x1b	114	10	)	)	-RRB-
cord-252230-s1qd3x1b	114	11	and	and	CC
cord-252230-s1qd3x1b	114	12	has	have	VBZ
cord-252230-s1qd3x1b	114	13	emerged	emerge	VBN
cord-252230-s1qd3x1b	114	14	as	as	IN
cord-252230-s1qd3x1b	114	15	a	a	DT
cord-252230-s1qd3x1b	114	16	key	key	JJ
cord-252230-s1qd3x1b	114	17	regulator	regulator	NN
cord-252230-s1qd3x1b	114	18	of	of	IN
cord-252230-s1qd3x1b	114	19	inflammation	inflammation	NN
cord-252230-s1qd3x1b	114	20	and	and	CC
cord-252230-s1qd3x1b	114	21	immunity	immunity	NN
cord-252230-s1qd3x1b	114	22	.	.	.
cord-252230-s1qd3x1b	115	1	Previous	previous	JJ
cord-252230-s1qd3x1b	115	2	studies	study	NNS
cord-252230-s1qd3x1b	115	3	have	have	VBP
cord-252230-s1qd3x1b	115	4	implicated	implicate	VBN
cord-252230-s1qd3x1b	115	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	115	6	in	in	IN
cord-252230-s1qd3x1b	115	7	antigen	antigen	NN
cord-252230-s1qd3x1b	115	8	presentation	presentation	NN
cord-252230-s1qd3x1b	115	9	to	to	IN
cord-252230-s1qd3x1b	115	10	T	t	NN
cord-252230-s1qd3x1b	115	11	cells	cell	NNS
cord-252230-s1qd3x1b	115	12	by	by	IN
cord-252230-s1qd3x1b	115	13	major	major	JJ
cord-252230-s1qd3x1b	115	14	histocompatibility	histocompatibility	NN
cord-252230-s1qd3x1b	115	15	complex	complex	NN
cord-252230-s1qd3x1b	115	16	(	(	-LRB-
cord-252230-s1qd3x1b	115	17	MHC	MHC	NNP
cord-252230-s1qd3x1b	115	18	)	)	-RRB-
cord-252230-s1qd3x1b	115	19	molecules	molecule	NNS
cord-252230-s1qd3x1b	115	20	(	(	-LRB-
cord-252230-s1qd3x1b	115	21	Dengjel	Dengjel	NNP
cord-252230-s1qd3x1b	115	22	et	et	NNP
cord-252230-s1qd3x1b	115	23	al	al	NNP
cord-252230-s1qd3x1b	115	24	.	.	NNP
cord-252230-s1qd3x1b	115	25	,	,	,
cord-252230-s1qd3x1b	115	26	2005	2005	CD
cord-252230-s1qd3x1b	115	27	;	;	:
cord-252230-s1qd3x1b	115	28	Schmid	Schmid	NNP
cord-252230-s1qd3x1b	115	29	et	et	NNP
cord-252230-s1qd3x1b	115	30	al	al	NNP
cord-252230-s1qd3x1b	115	31	.	.	NNP
cord-252230-s1qd3x1b	115	32	,	,	,
cord-252230-s1qd3x1b	115	33	2007	2007	CD
cord-252230-s1qd3x1b	115	34	)	)	-RRB-
cord-252230-s1qd3x1b	115	35	.	.	.
cord-252230-s1qd3x1b	116	1	However	however	RB
cord-252230-s1qd3x1b	116	2	,	,	,
cord-252230-s1qd3x1b	116	3	optimal	optimal	JJ
cord-252230-s1qd3x1b	116	4	MHC	MHC	NNP
cord-252230-s1qd3x1b	116	5	-	-	HYPH
cord-252230-s1qd3x1b	116	6	II	II	NNP
cord-252230-s1qd3x1b	116	7	presentation	presentation	NN
cord-252230-s1qd3x1b	116	8	of	of	IN
cord-252230-s1qd3x1b	116	9	peptides	peptide	NNS
cord-252230-s1qd3x1b	116	10	from	from	IN
cord-252230-s1qd3x1b	116	11	phagocytosed	phagocytosed	JJ
cord-252230-s1qd3x1b	116	12	pathogens	pathogen	NNS
cord-252230-s1qd3x1b	116	13	requires	require	VBZ
cord-252230-s1qd3x1b	116	14	LC3	LC3	NNP
cord-252230-s1qd3x1b	116	15	targeting	target	VBG
cord-252230-s1qd3x1b	116	16	to	to	IN
cord-252230-s1qd3x1b	116	17	phagosomes	phagosome	NNS
cord-252230-s1qd3x1b	116	18	by	by	IN
cord-252230-s1qd3x1b	116	19	ATGs	atg	NNS
cord-252230-s1qd3x1b	116	20	and	and	CC
cord-252230-s1qd3x1b	116	21	NOX2	NOX2	NNP
cord-252230-s1qd3x1b	116	22	,	,	,
cord-252230-s1qd3x1b	116	23	suggesting	suggest	VBG
cord-252230-s1qd3x1b	116	24	that	that	IN
cord-252230-s1qd3x1b	116	25	LAP	LAP	NNP
cord-252230-s1qd3x1b	116	26	mediates	mediate	VBZ
cord-252230-s1qd3x1b	116	27	presentation	presentation	NN
cord-252230-s1qd3x1b	116	28	of	of	IN
cord-252230-s1qd3x1b	116	29	extracellularly	extracellularly	RB
cord-252230-s1qd3x1b	116	30	derived	derive	VBN
cord-252230-s1qd3x1b	116	31	antigens	antigen	NNS
cord-252230-s1qd3x1b	116	32	(	(	-LRB-
cord-252230-s1qd3x1b	116	33	Romao	Romao	NNP
cord-252230-s1qd3x1b	116	34	et	et	NNP
cord-252230-s1qd3x1b	116	35	al	al	NNP
cord-252230-s1qd3x1b	116	36	.	.	NNP
cord-252230-s1qd3x1b	116	37	,	,	,
cord-252230-s1qd3x1b	116	38	2013	2013	CD
cord-252230-s1qd3x1b	116	39	)	)	-RRB-
cord-252230-s1qd3x1b	116	40	.	.	.
cord-252230-s1qd3x1b	117	1	Importantly	importantly	RB
cord-252230-s1qd3x1b	117	2	,	,	,
cord-252230-s1qd3x1b	117	3	LAP	LAP	NNP
cord-252230-s1qd3x1b	117	4	directs	direct	VBZ
cord-252230-s1qd3x1b	117	5	the	the	DT
cord-252230-s1qd3x1b	117	6	production	production	NN
cord-252230-s1qd3x1b	117	7	of	of	IN
cord-252230-s1qd3x1b	117	8	type	type	NN
cord-252230-s1qd3x1b	118	1	I	-PRON-	PRP
cord-252230-s1qd3x1b	118	2	IFN	IFN	NNP
cord-252230-s1qd3x1b	118	3	(	(	-LRB-
cord-252230-s1qd3x1b	118	4	IFN	IFN	NNP
cord-252230-s1qd3x1b	118	5	-	-	HYPH
cord-252230-s1qd3x1b	118	6	I	I	NNP
cord-252230-s1qd3x1b	118	7	)	)	-RRB-
cord-252230-s1qd3x1b	118	8	,	,	,
cord-252230-s1qd3x1b	118	9	namely	namely	RB
cord-252230-s1qd3x1b	118	10	IFN	IFN	NNP
cord-252230-s1qd3x1b	118	11	-	-	HYPH
cord-252230-s1qd3x1b	118	12	α	α	NNP
cord-252230-s1qd3x1b	118	13	,	,	,
cord-252230-s1qd3x1b	118	14	in	in	IN
cord-252230-s1qd3x1b	118	15	response	response	NN
cord-252230-s1qd3x1b	118	16	to	to	IN
cord-252230-s1qd3x1b	118	17	host	host	NN
cord-252230-s1qd3x1b	118	18	-	-	HYPH
cord-252230-s1qd3x1b	118	19	DNA	dna	NN
cord-252230-s1qd3x1b	118	20	containing	contain	VBG
cord-252230-s1qd3x1b	118	21	immune	immune	JJ
cord-252230-s1qd3x1b	118	22	complexes	complex	NNS
cord-252230-s1qd3x1b	118	23	by	by	IN
cord-252230-s1qd3x1b	118	24	plasmacytoid	plasmacytoid	NNP
cord-252230-s1qd3x1b	118	25	dendritic	dendritic	JJ
cord-252230-s1qd3x1b	118	26	cells	cell	NNS
cord-252230-s1qd3x1b	118	27	(	(	-LRB-
cord-252230-s1qd3x1b	118	28	Henault	Henault	NNP
cord-252230-s1qd3x1b	118	29	et	et	NNP
cord-252230-s1qd3x1b	118	30	al	al	NNP
cord-252230-s1qd3x1b	118	31	.	.	NNP
cord-252230-s1qd3x1b	118	32	,	,	,
cord-252230-s1qd3x1b	118	33	2012	2012	CD
cord-252230-s1qd3x1b	118	34	)	)	-RRB-
cord-252230-s1qd3x1b	118	35	.	.	.
cord-252230-s1qd3x1b	119	1	In	in	IN
cord-252230-s1qd3x1b	119	2	addition	addition	NN
cord-252230-s1qd3x1b	119	3	to	to	IN
cord-252230-s1qd3x1b	119	4	controlling	control	VBG
cord-252230-s1qd3x1b	119	5	the	the	DT
cord-252230-s1qd3x1b	119	6	immune	immune	JJ
cord-252230-s1qd3x1b	119	7	response	response	NN
cord-252230-s1qd3x1b	119	8	,	,	,
cord-252230-s1qd3x1b	119	9	LAP	lap	NN
cord-252230-s1qd3x1b	119	10	is	be	VBZ
cord-252230-s1qd3x1b	119	11	required	require	VBN
cord-252230-s1qd3x1b	119	12	for	for	IN
cord-252230-s1qd3x1b	119	13	the	the	DT
cord-252230-s1qd3x1b	119	14	phagocytosis	phagocytosis	NN
cord-252230-s1qd3x1b	119	15	and	and	CC
cord-252230-s1qd3x1b	119	16	degradation	degradation	NN
cord-252230-s1qd3x1b	119	17	of	of	IN
cord-252230-s1qd3x1b	119	18	photoreceptor	photoreceptor	NN
cord-252230-s1qd3x1b	119	19	outer	outer	JJ
cord-252230-s1qd3x1b	119	20	segments	segment	NNS
cord-252230-s1qd3x1b	119	21	by	by	IN
cord-252230-s1qd3x1b	119	22	retinal	retinal	JJ
cord-252230-s1qd3x1b	119	23	pigment	pigment	NN
cord-252230-s1qd3x1b	119	24	epithelial	epithelial	JJ
cord-252230-s1qd3x1b	119	25	cells	cell	NNS
cord-252230-s1qd3x1b	119	26	in	in	IN
cord-252230-s1qd3x1b	119	27	mice	mouse	NNS
cord-252230-s1qd3x1b	119	28	,	,	,
cord-252230-s1qd3x1b	119	29	which	which	WDT
cord-252230-s1qd3x1b	119	30	is	be	VBZ
cord-252230-s1qd3x1b	119	31	essential	essential	JJ
cord-252230-s1qd3x1b	119	32	for	for	IN
cord-252230-s1qd3x1b	119	33	proper	proper	JJ
cord-252230-s1qd3x1b	119	34	vision	vision	NN
cord-252230-s1qd3x1b	119	35	(	(	-LRB-
cord-252230-s1qd3x1b	119	36	Kim	Kim	NNP
cord-252230-s1qd3x1b	119	37	et	et	NNP
cord-252230-s1qd3x1b	119	38	al	al	NNP
cord-252230-s1qd3x1b	119	39	.	.	NNP
cord-252230-s1qd3x1b	119	40	,	,	,
cord-252230-s1qd3x1b	119	41	2013	2013	CD
cord-252230-s1qd3x1b	119	42	)	)	-RRB-
cord-252230-s1qd3x1b	119	43	.	.	.
cord-252230-s1qd3x1b	120	1	Overall	overall	RB
cord-252230-s1qd3x1b	120	2	,	,	,
cord-252230-s1qd3x1b	120	3	these	these	DT
cord-252230-s1qd3x1b	120	4	studies	study	NNS
cord-252230-s1qd3x1b	120	5	reinforce	reinforce	VBP
cord-252230-s1qd3x1b	120	6	the	the	DT
cord-252230-s1qd3x1b	120	7	physiological	physiological	JJ
cord-252230-s1qd3x1b	120	8	importance	importance	NN
cord-252230-s1qd3x1b	120	9	of	of	IN
cord-252230-s1qd3x1b	120	10	LAP	lap	NN
cord-252230-s1qd3x1b	120	11	as	as	IN
cord-252230-s1qd3x1b	120	12	an	an	DT
cord-252230-s1qd3x1b	120	13	autophagy	autophagy	NN
cord-252230-s1qd3x1b	120	14	-	-	HYPH
cord-252230-s1qd3x1b	120	15	related	relate	VBN
cord-252230-s1qd3x1b	120	16	pathway	pathway	NN
cord-252230-s1qd3x1b	120	17	.	.	.
cord-252230-s1qd3x1b	121	1	In	in	IN
cord-252230-s1qd3x1b	121	2	addition	addition	NN
cord-252230-s1qd3x1b	121	3	to	to	IN
cord-252230-s1qd3x1b	121	4	LAP	lap	NN
cord-252230-s1qd3x1b	121	5	,	,	,
cord-252230-s1qd3x1b	121	6	studies	study	NNS
cord-252230-s1qd3x1b	121	7	have	have	VBP
cord-252230-s1qd3x1b	121	8	uncovered	uncover	VBN
cord-252230-s1qd3x1b	121	9	a	a	DT
cord-252230-s1qd3x1b	121	10	growing	grow	VBG
cord-252230-s1qd3x1b	121	11	list	list	NN
cord-252230-s1qd3x1b	121	12	of	of	IN
cord-252230-s1qd3x1b	121	13	nonautophagic	nonautophagic	JJ
cord-252230-s1qd3x1b	121	14	functions	function	NNS
cord-252230-s1qd3x1b	121	15	mediated	mediate	VBN
cord-252230-s1qd3x1b	121	16	by	by	IN
cord-252230-s1qd3x1b	121	17	ATGs	atg	NNS
cord-252230-s1qd3x1b	121	18	that	that	WDT
cord-252230-s1qd3x1b	121	19	modulate	modulate	VBP
cord-252230-s1qd3x1b	121	20	the	the	DT
cord-252230-s1qd3x1b	121	21	infection	infection	NN
cord-252230-s1qd3x1b	121	22	of	of	IN
cord-252230-s1qd3x1b	121	23	host	host	NN
cord-252230-s1qd3x1b	121	24	cells	cell	NNS
cord-252230-s1qd3x1b	121	25	and	and	CC
cord-252230-s1qd3x1b	121	26	tissues	tissue	NNS
cord-252230-s1qd3x1b	121	27	.	.	.
cord-252230-s1qd3x1b	122	1	In	in	IN
cord-252230-s1qd3x1b	122	2	this	this	DT
cord-252230-s1qd3x1b	122	3	section	section	NN
cord-252230-s1qd3x1b	122	4	,	,	,
cord-252230-s1qd3x1b	122	5	we	-PRON-	PRP
cord-252230-s1qd3x1b	122	6	focus	focus	VBP
cord-252230-s1qd3x1b	122	7	on	on	IN
cord-252230-s1qd3x1b	122	8	how	how	WRB
cord-252230-s1qd3x1b	122	9	individual	individual	JJ
cord-252230-s1qd3x1b	122	10	ATGs	atg	NNS
cord-252230-s1qd3x1b	122	11	can	can	MD
cord-252230-s1qd3x1b	122	12	either	either	CC
cord-252230-s1qd3x1b	122	13	augment	augment	VB
cord-252230-s1qd3x1b	122	14	or	or	CC
cord-252230-s1qd3x1b	122	15	diminish	diminish	VB
cord-252230-s1qd3x1b	122	16	the	the	DT
cord-252230-s1qd3x1b	122	17	propagation	propagation	NN
cord-252230-s1qd3x1b	122	18	of	of	IN
cord-252230-s1qd3x1b	122	19	assorted	assorted	JJ
cord-252230-s1qd3x1b	122	20	viruses	virus	NNS
cord-252230-s1qd3x1b	122	21	as	as	RB
cord-252230-s1qd3x1b	122	22	well	well	RB
cord-252230-s1qd3x1b	122	23	as	as	IN
cord-252230-s1qd3x1b	122	24	how	how	WRB
cord-252230-s1qd3x1b	122	25	ATGs	atg	NNS
cord-252230-s1qd3x1b	122	26	restrict	restrict	VBP
cord-252230-s1qd3x1b	122	27	intracellular	intracellular	JJ
cord-252230-s1qd3x1b	122	28	pathogens	pathogen	NNS
cord-252230-s1qd3x1b	122	29	via	via	IN
cord-252230-s1qd3x1b	122	30	pathways	pathway	NNS
cord-252230-s1qd3x1b	122	31	that	that	WDT
cord-252230-s1qd3x1b	122	32	are	be	VBP
cord-252230-s1qd3x1b	122	33	distinct	distinct	JJ
cord-252230-s1qd3x1b	122	34	from	from	IN
cord-252230-s1qd3x1b	122	35	both	both	DT
cord-252230-s1qd3x1b	122	36	classic	classic	JJ
cord-252230-s1qd3x1b	122	37	autophagy	autophagy	NN
cord-252230-s1qd3x1b	122	38	and	and	CC
cord-252230-s1qd3x1b	122	39	LAP	lap	NN
cord-252230-s1qd3x1b	122	40	.	.	.
cord-252230-s1qd3x1b	123	1	Subversion	subversion	NN
cord-252230-s1qd3x1b	123	2	during	during	IN
cord-252230-s1qd3x1b	123	3	viral	viral	JJ
cord-252230-s1qd3x1b	123	4	replication	replication	NN
cord-252230-s1qd3x1b	123	5	and	and	CC
cord-252230-s1qd3x1b	123	6	transmission	transmission	NN
cord-252230-s1qd3x1b	123	7	.	.	.
cord-252230-s1qd3x1b	124	1	Growing	grow	VBG
cord-252230-s1qd3x1b	124	2	evidence	evidence	NN
cord-252230-s1qd3x1b	124	3	supports	support	VBZ
cord-252230-s1qd3x1b	124	4	that	that	IN
cord-252230-s1qd3x1b	124	5	viruses	virus	NNS
cord-252230-s1qd3x1b	124	6	use	use	VBP
cord-252230-s1qd3x1b	124	7	LC3	lc3	NN
cord-252230-s1qd3x1b	124	8	+	+	SYM
cord-252230-s1qd3x1b	124	9	membranes	membrane	NNS
cord-252230-s1qd3x1b	124	10	to	to	TO
cord-252230-s1qd3x1b	124	11	exit	exit	VB
cord-252230-s1qd3x1b	124	12	host	host	NN
cord-252230-s1qd3x1b	124	13	cells	cell	NNS
cord-252230-s1qd3x1b	124	14	via	via	IN
cord-252230-s1qd3x1b	124	15	exocytic	exocytic	JJ
cord-252230-s1qd3x1b	124	16	pathways	pathway	NNS
cord-252230-s1qd3x1b	124	17	analogous	analogous	JJ
cord-252230-s1qd3x1b	124	18	to	to	IN
cord-252230-s1qd3x1b	124	19	secretory	secretory	JJ
cord-252230-s1qd3x1b	124	20	autophagy	autophagy	NN
cord-252230-s1qd3x1b	124	21	(	(	-LRB-
cord-252230-s1qd3x1b	124	22	Fig	fig	NN
cord-252230-s1qd3x1b	124	23	.	.	NNP
cord-252230-s1qd3x1b	124	24	2	2	CD
cord-252230-s1qd3x1b	124	25	)	)	-RRB-
cord-252230-s1qd3x1b	124	26	.	.	.
cord-252230-s1qd3x1b	125	1	Infections	infection	NNS
cord-252230-s1qd3x1b	125	2	by	by	IN
cord-252230-s1qd3x1b	125	3	poliovirus	poliovirus	NN
cord-252230-s1qd3x1b	125	4	and	and	CC
cord-252230-s1qd3x1b	125	5	coxsackievirus	coxsackievirus	NNP
cord-252230-s1qd3x1b	125	6	B	B	NNP
cord-252230-s1qd3x1b	125	7	(	(	-LRB-
cord-252230-s1qd3x1b	125	8	CVB	CVB	NNP
cord-252230-s1qd3x1b	125	9	)	)	-RRB-
cord-252230-s1qd3x1b	125	10	,	,	,
cord-252230-s1qd3x1b	125	11	two	two	CD
cord-252230-s1qd3x1b	125	12	nonenveloped	nonenveloped	NNP
cord-252230-s1qd3x1b	125	13	RNA	RNA	NNP
cord-252230-s1qd3x1b	125	14	viruses	virus	NNS
cord-252230-s1qd3x1b	125	15	,	,	,
cord-252230-s1qd3x1b	125	16	result	result	VB
cord-252230-s1qd3x1b	125	17	in	in	IN
cord-252230-s1qd3x1b	125	18	the	the	DT
cord-252230-s1qd3x1b	125	19	formation	formation	NN
cord-252230-s1qd3x1b	125	20	of	of	IN
cord-252230-s1qd3x1b	125	21	LC3	LC3	NNP
cord-252230-s1qd3x1b	125	22	+	+	CC
cord-252230-s1qd3x1b	125	23	double	double	JJ
cord-252230-s1qd3x1b	125	24	membrane	membrane	NN
cord-252230-s1qd3x1b	125	25	vesicles	vesicle	NNS
cord-252230-s1qd3x1b	125	26	in	in	IN
cord-252230-s1qd3x1b	125	27	an	an	DT
cord-252230-s1qd3x1b	125	28	ATG	ATG	NNP
cord-252230-s1qd3x1b	125	29	-	-	HYPH
cord-252230-s1qd3x1b	125	30	dependent	dependent	JJ
cord-252230-s1qd3x1b	125	31	manner	manner	NN
cord-252230-s1qd3x1b	125	32	,	,	,
cord-252230-s1qd3x1b	125	33	which	which	WDT
cord-252230-s1qd3x1b	125	34	serve	serve	VBP
cord-252230-s1qd3x1b	125	35	as	as	IN
cord-252230-s1qd3x1b	125	36	scaffolds	scaffold	NNS
cord-252230-s1qd3x1b	125	37	for	for	IN
cord-252230-s1qd3x1b	125	38	viral	viral	JJ
cord-252230-s1qd3x1b	125	39	replication	replication	NN
cord-252230-s1qd3x1b	125	40	complexes	complex	NNS
cord-252230-s1qd3x1b	126	1	(	(	-LRB-
cord-252230-s1qd3x1b	126	2	Jackson	Jackson	NNP
cord-252230-s1qd3x1b	126	3	et	et	NNP
cord-252230-s1qd3x1b	126	4	al	al	NNP
cord-252230-s1qd3x1b	126	5	.	.	NNP
cord-252230-s1qd3x1b	126	6	,	,	,
cord-252230-s1qd3x1b	126	7	2005	2005	CD
cord-252230-s1qd3x1b	126	8	;	;	:
cord-252230-s1qd3x1b	126	9	Wong	Wong	NNP
cord-252230-s1qd3x1b	126	10	et	et	NNP
cord-252230-s1qd3x1b	126	11	al	al	NNP
cord-252230-s1qd3x1b	126	12	.	.	NNP
cord-252230-s1qd3x1b	126	13	,	,	,
cord-252230-s1qd3x1b	126	14	2008	2008	CD
cord-252230-s1qd3x1b	126	15	)	)	-RRB-
cord-252230-s1qd3x1b	126	16	.	.	.
cord-252230-s1qd3x1b	127	1	Instead	instead	RB
cord-252230-s1qd3x1b	127	2	of	of	IN
cord-252230-s1qd3x1b	127	3	degradation	degradation	NN
cord-252230-s1qd3x1b	127	4	in	in	IN
cord-252230-s1qd3x1b	127	5	the	the	DT
cord-252230-s1qd3x1b	127	6	lysosome	lysosome	NN
cord-252230-s1qd3x1b	127	7	,	,	,
cord-252230-s1qd3x1b	127	8	sequestered	sequester	VBN
cord-252230-s1qd3x1b	127	9	virions	virion	NNS
cord-252230-s1qd3x1b	127	10	are	be	VBP
cord-252230-s1qd3x1b	127	11	released	release	VBN
cord-252230-s1qd3x1b	127	12	from	from	IN
cord-252230-s1qd3x1b	127	13	cells	cell	NNS
cord-252230-s1qd3x1b	127	14	within	within	IN
cord-252230-s1qd3x1b	127	15	a	a	DT
cord-252230-s1qd3x1b	127	16	membrane	membrane	NN
cord-252230-s1qd3x1b	127	17	coat	coat	NN
cord-252230-s1qd3x1b	127	18	through	through	IN
cord-252230-s1qd3x1b	127	19	a	a	DT
cord-252230-s1qd3x1b	127	20	process	process	NN
cord-252230-s1qd3x1b	127	21	termed	term	VBN
cord-252230-s1qd3x1b	127	22	autophagosome	autophagosome	RB
cord-252230-s1qd3x1b	127	23	-	-	HYPH
cord-252230-s1qd3x1b	127	24	mediated	mediate	VBN
cord-252230-s1qd3x1b	127	25	exit	exit	NN
cord-252230-s1qd3x1b	127	26	without	without	IN
cord-252230-s1qd3x1b	127	27	lysis	lysis	NN
cord-252230-s1qd3x1b	127	28	(	(	-LRB-
cord-252230-s1qd3x1b	127	29	Fig	fig	NN
cord-252230-s1qd3x1b	127	30	.	.	.
cord-252230-s1qd3x1b	127	31	2	2	CD
cord-252230-s1qd3x1b	127	32	A	a	NN
cord-252230-s1qd3x1b	127	33	;	;	:
cord-252230-s1qd3x1b	127	34	Taylor	Taylor	NNP
cord-252230-s1qd3x1b	127	35	et	et	NNP
cord-252230-s1qd3x1b	127	36	al	al	NNP
cord-252230-s1qd3x1b	127	37	.	.	NNP
cord-252230-s1qd3x1b	127	38	,	,	,
cord-252230-s1qd3x1b	127	39	2009	2009	CD
cord-252230-s1qd3x1b	127	40	)	)	-RRB-
cord-252230-s1qd3x1b	127	41	.	.	.
cord-252230-s1qd3x1b	128	1	The	the	DT
cord-252230-s1qd3x1b	128	2	"	"	``
cord-252230-s1qd3x1b	128	3	envelope	envelope	NN
cord-252230-s1qd3x1b	128	4	"	"	''
cord-252230-s1qd3x1b	128	5	acquired	acquire	VBN
cord-252230-s1qd3x1b	128	6	during	during	IN
cord-252230-s1qd3x1b	128	7	egress	egress	NN
cord-252230-s1qd3x1b	128	8	shields	shield	NNS
cord-252230-s1qd3x1b	128	9	virion	virion	NN
cord-252230-s1qd3x1b	128	10	clusters	cluster	NNS
cord-252230-s1qd3x1b	128	11	from	from	IN
cord-252230-s1qd3x1b	128	12	immune	immune	JJ
cord-252230-s1qd3x1b	128	13	recognition	recognition	NN
cord-252230-s1qd3x1b	128	14	and	and	CC
cord-252230-s1qd3x1b	128	15	aids	aids	NNP
cord-252230-s1qd3x1b	128	16	entry	entry	NN
cord-252230-s1qd3x1b	128	17	into	into	IN
cord-252230-s1qd3x1b	128	18	neighboring	neighboring	NN
cord-252230-s1qd3x1b	128	19	cells	cell	NNS
cord-252230-s1qd3x1b	128	20	(	(	-LRB-
cord-252230-s1qd3x1b	128	21	Bird	Bird	NNP
cord-252230-s1qd3x1b	128	22	et	et	NNP
cord-252230-s1qd3x1b	128	23	al	al	NNP
cord-252230-s1qd3x1b	128	24	.	.	NNP
cord-252230-s1qd3x1b	128	25	,	,	,
cord-252230-s1qd3x1b	128	26	2014	2014	CD
cord-252230-s1qd3x1b	128	27	;	;	:
cord-252230-s1qd3x1b	128	28	Chen	Chen	NNP
cord-252230-s1qd3x1b	128	29	et	et	NNP
cord-252230-s1qd3x1b	128	30	al	al	NNP
cord-252230-s1qd3x1b	128	31	.	.	.
cord-252230-s1qd3x1b	129	1	,	,	,
cord-252230-s1qd3x1b	129	2	2015b	2015b	CD
cord-252230-s1qd3x1b	129	3	)	)	-RRB-
cord-252230-s1qd3x1b	129	4	.	.	.
cord-252230-s1qd3x1b	130	1	Consistent	consistent	JJ
cord-252230-s1qd3x1b	130	2	with	with	IN
cord-252230-s1qd3x1b	130	3	these	these	DT
cord-252230-s1qd3x1b	130	4	studies	study	NNS
cord-252230-s1qd3x1b	130	5	that	that	IN
cord-252230-s1qd3x1b	130	6	an	an	DT
cord-252230-s1qd3x1b	130	7	autophagy	autophagy	NN
cord-252230-s1qd3x1b	130	8	-	-	HYPH
cord-252230-s1qd3x1b	130	9	like	like	JJ
cord-252230-s1qd3x1b	130	10	process	process	NN
cord-252230-s1qd3x1b	130	11	is	be	VBZ
cord-252230-s1qd3x1b	130	12	required	require	VBN
cord-252230-s1qd3x1b	130	13	for	for	IN
cord-252230-s1qd3x1b	130	14	viral	viral	JJ
cord-252230-s1qd3x1b	130	15	replication	replication	NN
cord-252230-s1qd3x1b	130	16	and	and	CC
cord-252230-s1qd3x1b	130	17	spread	spread	NN
cord-252230-s1qd3x1b	130	18	,	,	,
cord-252230-s1qd3x1b	130	19	ATG5	atg5	JJ
cord-252230-s1qd3x1b	130	20	deletion	deletion	NN
cord-252230-s1qd3x1b	130	21	in	in	IN
cord-252230-s1qd3x1b	130	22	pancreatic	pancreatic	JJ
cord-252230-s1qd3x1b	130	23	acinar	acinar	NN
cord-252230-s1qd3x1b	130	24	cells	cell	NNS
cord-252230-s1qd3x1b	130	25	of	of	IN
cord-252230-s1qd3x1b	130	26	mice	mouse	NNS
cord-252230-s1qd3x1b	130	27	leads	lead	VBZ
cord-252230-s1qd3x1b	130	28	to	to	IN
cord-252230-s1qd3x1b	130	29	a	a	DT
cord-252230-s1qd3x1b	130	30	2,000-fold	2,000-fold	CD
cord-252230-s1qd3x1b	130	31	reduction	reduction	NN
cord-252230-s1qd3x1b	130	32	in	in	IN
cord-252230-s1qd3x1b	130	33	CVB	CVB	NNP
cord-252230-s1qd3x1b	130	34	replication	replication	NN
cord-252230-s1qd3x1b	130	35	and	and	CC
cord-252230-s1qd3x1b	130	36	protection	protection	NN
cord-252230-s1qd3x1b	130	37	from	from	IN
cord-252230-s1qd3x1b	130	38	pancreatitis	pancreatitis	NN
cord-252230-s1qd3x1b	130	39	(	(	-LRB-
cord-252230-s1qd3x1b	130	40	Alirezaei	Alirezaei	NNP
cord-252230-s1qd3x1b	130	41	et	et	FW
cord-252230-s1qd3x1b	130	42	al	al	NNP
cord-252230-s1qd3x1b	130	43	.	.	NNP
cord-252230-s1qd3x1b	130	44	,	,	,
cord-252230-s1qd3x1b	130	45	2012	2012	CD
cord-252230-s1qd3x1b	130	46	)	)	-RRB-
cord-252230-s1qd3x1b	130	47	.	.	.
cord-252230-s1qd3x1b	131	1	In	in	IN
cord-252230-s1qd3x1b	131	2	addition	addition	NN
cord-252230-s1qd3x1b	131	3	to	to	IN
cord-252230-s1qd3x1b	131	4	these	these	DT
cord-252230-s1qd3x1b	131	5	picornaviruses	picornavirus	NNS
cord-252230-s1qd3x1b	131	6	,	,	,
cord-252230-s1qd3x1b	131	7	lipidated	lipidate	VBN
cord-252230-s1qd3x1b	131	8	LC3	LC3	NNP
cord-252230-s1qd3x1b	131	9	also	also	RB
cord-252230-s1qd3x1b	131	10	contributes	contribute	VBZ
cord-252230-s1qd3x1b	131	11	to	to	IN
cord-252230-s1qd3x1b	131	12	the	the	DT
cord-252230-s1qd3x1b	131	13	envelopment	envelopment	NN
cord-252230-s1qd3x1b	131	14	and	and	CC
cord-252230-s1qd3x1b	131	15	exocytosis	exocytosis	NN
cord-252230-s1qd3x1b	131	16	of	of	IN
cord-252230-s1qd3x1b	131	17	certain	certain	JJ
cord-252230-s1qd3x1b	131	18	herpesviruses	herpesviruse	NNS
cord-252230-s1qd3x1b	131	19	during	during	IN
cord-252230-s1qd3x1b	131	20	lytic	lytic	JJ
cord-252230-s1qd3x1b	131	21	infection	infection	NN
cord-252230-s1qd3x1b	131	22	.	.	.
cord-252230-s1qd3x1b	132	1	Epstein	Epstein	NNP
cord-252230-s1qd3x1b	132	2	-	-	HYPH
cord-252230-s1qd3x1b	132	3	Barr	Barr	NNP
cord-252230-s1qd3x1b	132	4	virus	virus	NN
cord-252230-s1qd3x1b	132	5	and	and	CC
cord-252230-s1qd3x1b	132	6	varicella	varicella	NN
cord-252230-s1qd3x1b	132	7	-	-	HYPH
cord-252230-s1qd3x1b	132	8	zoster	zoster	NN
cord-252230-s1qd3x1b	132	9	virus	virus	NN
cord-252230-s1qd3x1b	132	10	acquire	acquire	VBP
cord-252230-s1qd3x1b	132	11	LC3-conjugated	lc3-conjugated	JJ
cord-252230-s1qd3x1b	132	12	membranes	membrane	NNS
cord-252230-s1qd3x1b	132	13	during	during	IN
cord-252230-s1qd3x1b	132	14	envelope	envelope	NN
cord-252230-s1qd3x1b	132	15	acquisition	acquisition	NN
cord-252230-s1qd3x1b	132	16	in	in	IN
cord-252230-s1qd3x1b	132	17	the	the	DT
cord-252230-s1qd3x1b	132	18	cytosol	cytosol	NN
cord-252230-s1qd3x1b	132	19	,	,	,
cord-252230-s1qd3x1b	132	20	which	which	WDT
cord-252230-s1qd3x1b	132	21	can	can	MD
cord-252230-s1qd3x1b	132	22	be	be	VB
cord-252230-s1qd3x1b	132	23	detected	detect	VBN
cord-252230-s1qd3x1b	132	24	in	in	IN
cord-252230-s1qd3x1b	132	25	purified	purify	VBN
cord-252230-s1qd3x1b	132	26	virions	virion	NNS
cord-252230-s1qd3x1b	132	27	(	(	-LRB-
cord-252230-s1qd3x1b	132	28	Fig	fig	NN
cord-252230-s1qd3x1b	132	29	.	.	NN
cord-252230-s1qd3x1b	132	30	2	2	CD
cord-252230-s1qd3x1b	132	31	B	b	NN
cord-252230-s1qd3x1b	132	32	;	;	:
cord-252230-s1qd3x1b	133	1	Nowag	Nowag	NNP
cord-252230-s1qd3x1b	133	2	et	et	NNP
cord-252230-s1qd3x1b	133	3	al	al	NNP
cord-252230-s1qd3x1b	133	4	.	.	.
cord-252230-s1qd3x1b	134	1	,	,	,
cord-252230-s1qd3x1b	134	2	2014	2014	CD
cord-252230-s1qd3x1b	134	3	;	;	:
cord-252230-s1qd3x1b	134	4	Buckingham	Buckingham	NNP
cord-252230-s1qd3x1b	134	5	et	et	NNP
cord-252230-s1qd3x1b	134	6	al	al	NNP
cord-252230-s1qd3x1b	134	7	.	.	NNP
cord-252230-s1qd3x1b	134	8	,	,	,
cord-252230-s1qd3x1b	134	9	2016	2016	CD
cord-252230-s1qd3x1b	134	10	)	)	-RRB-
cord-252230-s1qd3x1b	134	11	.	.	.
cord-252230-s1qd3x1b	135	1	Accordingly	accordingly	RB
cord-252230-s1qd3x1b	135	2	,	,	,
cord-252230-s1qd3x1b	135	3	inhibiting	inhibit	VBG
cord-252230-s1qd3x1b	135	4	LC3	lc3	NN
cord-252230-s1qd3x1b	135	5	lipidation	lipidation	NN
cord-252230-s1qd3x1b	135	6	via	via	IN
cord-252230-s1qd3x1b	135	7	ATG12	ATG12	NNP
cord-252230-s1qd3x1b	135	8	or	or	CC
cord-252230-s1qd3x1b	135	9	ATG16L1	atg16l1	JJ
cord-252230-s1qd3x1b	135	10	knockdown	knockdown	NN
cord-252230-s1qd3x1b	135	11	impairs	impair	VBZ
cord-252230-s1qd3x1b	135	12	viral	viral	JJ
cord-252230-s1qd3x1b	135	13	exit	exit	NN
cord-252230-s1qd3x1b	135	14	and	and	CC
cord-252230-s1qd3x1b	135	15	results	result	NNS
cord-252230-s1qd3x1b	135	16	in	in	IN
cord-252230-s1qd3x1b	135	17	the	the	DT
cord-252230-s1qd3x1b	135	18	accumulation	accumulation	NN
cord-252230-s1qd3x1b	135	19	of	of	IN
cord-252230-s1qd3x1b	135	20	viral	viral	JJ
cord-252230-s1qd3x1b	135	21	DNA	dna	NN
cord-252230-s1qd3x1b	135	22	in	in	IN
cord-252230-s1qd3x1b	135	23	the	the	DT
cord-252230-s1qd3x1b	135	24	cytosol	cytosol	NN
cord-252230-s1qd3x1b	136	1	(	(	-LRB-
cord-252230-s1qd3x1b	136	2	Nowag	Nowag	NNP
cord-252230-s1qd3x1b	136	3	et	et	NNP
cord-252230-s1qd3x1b	136	4	al	al	NNP
cord-252230-s1qd3x1b	136	5	.	.	NNP
cord-252230-s1qd3x1b	136	6	,	,	,
cord-252230-s1qd3x1b	136	7	2014	2014	CD
cord-252230-s1qd3x1b	136	8	)	)	-RRB-
cord-252230-s1qd3x1b	136	9	.	.	.
cord-252230-s1qd3x1b	137	1	Finally	finally	RB
cord-252230-s1qd3x1b	137	2	,	,	,
cord-252230-s1qd3x1b	137	3	influenza	influenza	NN
cord-252230-s1qd3x1b	137	4	A	a	DT
cord-252230-s1qd3x1b	137	5	virus	virus	NN
cord-252230-s1qd3x1b	137	6	(	(	-LRB-
cord-252230-s1qd3x1b	137	7	IAV	IAV	NNP
cord-252230-s1qd3x1b	137	8	)	)	-RRB-
cord-252230-s1qd3x1b	137	9	encodes	encode	VBZ
cord-252230-s1qd3x1b	137	10	an	an	DT
cord-252230-s1qd3x1b	137	11	ion	ion	NN
cord-252230-s1qd3x1b	137	12	channel	channel	NN
cord-252230-s1qd3x1b	137	13	protein	protein	NN
cord-252230-s1qd3x1b	137	14	,	,	,
cord-252230-s1qd3x1b	137	15	matrix	matrix	NN
cord-252230-s1qd3x1b	137	16	protein	protein	NN
cord-252230-s1qd3x1b	137	17	2	2	CD
cord-252230-s1qd3x1b	137	18	,	,	,
cord-252230-s1qd3x1b	137	19	that	that	WDT
cord-252230-s1qd3x1b	137	20	blocks	block	VBZ
cord-252230-s1qd3x1b	137	21	lysosomal	lysosomal	JJ
cord-252230-s1qd3x1b	137	22	degradation	degradation	NN
cord-252230-s1qd3x1b	137	23	of	of	IN
cord-252230-s1qd3x1b	137	24	the	the	DT
cord-252230-s1qd3x1b	137	25	virion	virion	NN
cord-252230-s1qd3x1b	137	26	and	and	CC
cord-252230-s1qd3x1b	137	27	facilitates	facilitate	VBZ
cord-252230-s1qd3x1b	137	28	viral	viral	JJ
cord-252230-s1qd3x1b	137	29	egress	egress	NN
cord-252230-s1qd3x1b	137	30	through	through	IN
cord-252230-s1qd3x1b	137	31	binding	bind	VBG
cord-252230-s1qd3x1b	137	32	and	and	CC
cord-252230-s1qd3x1b	137	33	redirecting	redirect	VBG
cord-252230-s1qd3x1b	137	34	LC3-II	lc3-ii	NN
cord-252230-s1qd3x1b	137	35	to	to	IN
cord-252230-s1qd3x1b	137	36	the	the	DT
cord-252230-s1qd3x1b	137	37	plasma	plasma	NN
cord-252230-s1qd3x1b	137	38	membrane	membrane	NN
cord-252230-s1qd3x1b	137	39	.	.	.
cord-252230-s1qd3x1b	138	1	Notably	notably	RB
cord-252230-s1qd3x1b	138	2	,	,	,
cord-252230-s1qd3x1b	138	3	although	although	IN
cord-252230-s1qd3x1b	138	4	the	the	DT
cord-252230-s1qd3x1b	138	5	improved	improve	VBN
cord-252230-s1qd3x1b	138	6	filamentous	filamentous	JJ
cord-252230-s1qd3x1b	138	7	budding	budding	NN
cord-252230-s1qd3x1b	138	8	of	of	IN
cord-252230-s1qd3x1b	138	9	IAV	IAV	NNP
cord-252230-s1qd3x1b	138	10	is	be	VBZ
cord-252230-s1qd3x1b	138	11	dependent	dependent	JJ
cord-252230-s1qd3x1b	138	12	on	on	IN
cord-252230-s1qd3x1b	138	13	ATG	ATG	NNP
cord-252230-s1qd3x1b	138	14	conjugation	conjugation	NN
cord-252230-s1qd3x1b	138	15	pathways	pathway	NNS
cord-252230-s1qd3x1b	138	16	that	that	WDT
cord-252230-s1qd3x1b	138	17	lipidate	lipidate	NNP
cord-252230-s1qd3x1b	138	18	LC3	LC3	NNP
cord-252230-s1qd3x1b	138	19	,	,	,
cord-252230-s1qd3x1b	138	20	the	the	DT
cord-252230-s1qd3x1b	138	21	overall	overall	JJ
cord-252230-s1qd3x1b	138	22	infectious	infectious	JJ
cord-252230-s1qd3x1b	138	23	virus	virus	NN
cord-252230-s1qd3x1b	138	24	production	production	NN
cord-252230-s1qd3x1b	138	25	remains	remain	VBZ
cord-252230-s1qd3x1b	138	26	intact	intact	JJ
cord-252230-s1qd3x1b	138	27	(	(	-LRB-
cord-252230-s1qd3x1b	138	28	Fig	fig	NN
cord-252230-s1qd3x1b	138	29	.	.	.
cord-252230-s1qd3x1b	138	30	2	2	CD
cord-252230-s1qd3x1b	138	31	C	c	NN
cord-252230-s1qd3x1b	138	32	;	;	:
cord-252230-s1qd3x1b	138	33	Gannagé	Gannagé	NNP
cord-252230-s1qd3x1b	138	34	et	et	FW
cord-252230-s1qd3x1b	138	35	al	al	NNP
cord-252230-s1qd3x1b	138	36	.	.	.
cord-252230-s1qd3x1b	139	1	,	,	,
cord-252230-s1qd3x1b	139	2	2009	2009	CD
cord-252230-s1qd3x1b	139	3	;	;	:
cord-252230-s1qd3x1b	139	4	Beale	Beale	NNP
cord-252230-s1qd3x1b	139	5	et	et	NNP
cord-252230-s1qd3x1b	139	6	al	al	NNP
cord-252230-s1qd3x1b	139	7	.	.	.
cord-252230-s1qd3x1b	140	1	,	,	,
cord-252230-s1qd3x1b	140	2	2014	2014	CD
cord-252230-s1qd3x1b	140	3	)	)	-RRB-
cord-252230-s1qd3x1b	140	4	.	.	.
cord-252230-s1qd3x1b	141	1	In	in	IN
cord-252230-s1qd3x1b	141	2	addition	addition	NN
cord-252230-s1qd3x1b	141	3	to	to	IN
cord-252230-s1qd3x1b	141	4	these	these	DT
cord-252230-s1qd3x1b	141	5	effects	effect	NNS
cord-252230-s1qd3x1b	141	6	on	on	IN
cord-252230-s1qd3x1b	141	7	viral	viral	JJ
cord-252230-s1qd3x1b	141	8	exocytosis	exocytosis	NN
cord-252230-s1qd3x1b	141	9	,	,	,
cord-252230-s1qd3x1b	141	10	interactions	interaction	NNS
cord-252230-s1qd3x1b	141	11	with	with	IN
cord-252230-s1qd3x1b	141	12	LC3	LC3	NNP
cord-252230-s1qd3x1b	141	13	are	be	VBP
cord-252230-s1qd3x1b	141	14	also	also	RB
cord-252230-s1qd3x1b	141	15	required	require	VBN
cord-252230-s1qd3x1b	141	16	for	for	IN
cord-252230-s1qd3x1b	141	17	the	the	DT
cord-252230-s1qd3x1b	141	18	processing	processing	NN
cord-252230-s1qd3x1b	141	19	and	and	CC
cord-252230-s1qd3x1b	141	20	inclusion	inclusion	NN
cord-252230-s1qd3x1b	141	21	of	of	IN
cord-252230-s1qd3x1b	141	22	HIV	HIV	NNP
cord-252230-s1qd3x1b	141	23	Gag	Gag	NNP
cord-252230-s1qd3x1b	141	24	into	into	IN
cord-252230-s1qd3x1b	141	25	the	the	DT
cord-252230-s1qd3x1b	141	26	virion	virion	NN
cord-252230-s1qd3x1b	141	27	,	,	,
cord-252230-s1qd3x1b	141	28	whereas	whereas	IN
cord-252230-s1qd3x1b	141	29	HIV	HIV	NNP
cord-252230-s1qd3x1b	141	30	Nef	Nef	NNP
cord-252230-s1qd3x1b	141	31	inhibits	inhibit	VBZ
cord-252230-s1qd3x1b	141	32	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	141	33	to	to	TO
cord-252230-s1qd3x1b	141	34	prevent	prevent	VB
cord-252230-s1qd3x1b	141	35	virion	virion	NN
cord-252230-s1qd3x1b	141	36	degradation	degradation	NN
cord-252230-s1qd3x1b	141	37	through	through	IN
cord-252230-s1qd3x1b	141	38	autophagy	autophagy	NN
cord-252230-s1qd3x1b	141	39	(	(	-LRB-
cord-252230-s1qd3x1b	141	40	Kyei	Kyei	NNP
cord-252230-s1qd3x1b	141	41	et	et	NNP
cord-252230-s1qd3x1b	141	42	al	al	NNP
cord-252230-s1qd3x1b	141	43	.	.	NNP
cord-252230-s1qd3x1b	141	44	,	,	,
cord-252230-s1qd3x1b	141	45	2009	2009	CD
cord-252230-s1qd3x1b	141	46	)	)	-RRB-
cord-252230-s1qd3x1b	141	47	.	.	.
cord-252230-s1qd3x1b	142	1	In	in	IN
cord-252230-s1qd3x1b	142	2	contrast	contrast	NN
cord-252230-s1qd3x1b	142	3	,	,	,
cord-252230-s1qd3x1b	142	4	the	the	DT
cord-252230-s1qd3x1b	142	5	multilamellar	multilamellar	NNP
cord-252230-s1qd3x1b	142	6	membranes	membrane	NNS
cord-252230-s1qd3x1b	142	7	that	that	WDT
cord-252230-s1qd3x1b	142	8	harbor	harbor	VBP
cord-252230-s1qd3x1b	142	9	coronavirus	coronavirus	NN
cord-252230-s1qd3x1b	142	10	replication	replication	NN
cord-252230-s1qd3x1b	142	11	complexes	complex	NNS
cord-252230-s1qd3x1b	142	12	are	be	VBP
cord-252230-s1qd3x1b	142	13	decorated	decorate	VBN
cord-252230-s1qd3x1b	142	14	with	with	IN
cord-252230-s1qd3x1b	142	15	the	the	DT
cord-252230-s1qd3x1b	142	16	nonlipidated	nonlipidated	JJ
cord-252230-s1qd3x1b	142	17	form	form	NN
cord-252230-s1qd3x1b	142	18	of	of	IN
cord-252230-s1qd3x1b	142	19	LC3	lc3	NN
cord-252230-s1qd3x1b	142	20	;	;	:
cord-252230-s1qd3x1b	142	21	down	down	IN
cord-252230-s1qd3x1b	142	22	-	-	HYPH
cord-252230-s1qd3x1b	142	23	regulation	regulation	NN
cord-252230-s1qd3x1b	142	24	of	of	IN
cord-252230-s1qd3x1b	142	25	LC3	lc3	NN
cord-252230-s1qd3x1b	142	26	impairs	impair	VBZ
cord-252230-s1qd3x1b	142	27	viral	viral	JJ
cord-252230-s1qd3x1b	142	28	replication	replication	NN
cord-252230-s1qd3x1b	142	29	,	,	,
cord-252230-s1qd3x1b	142	30	but	but	CC
cord-252230-s1qd3x1b	142	31	ATG7	ATG7	NNP
cord-252230-s1qd3x1b	142	32	deletion	deletion	NN
cord-252230-s1qd3x1b	142	33	has	have	VBZ
cord-252230-s1qd3x1b	142	34	no	no	DT
cord-252230-s1qd3x1b	142	35	effect	effect	NN
cord-252230-s1qd3x1b	142	36	(	(	-LRB-
cord-252230-s1qd3x1b	142	37	Reggiori	Reggiori	NNP
cord-252230-s1qd3x1b	142	38	et	et	NNP
cord-252230-s1qd3x1b	142	39	al	al	NNP
cord-252230-s1qd3x1b	142	40	.	.	NNP
cord-252230-s1qd3x1b	142	41	,	,	,
cord-252230-s1qd3x1b	142	42	2010	2010	CD
cord-252230-s1qd3x1b	142	43	)	)	-RRB-
cord-252230-s1qd3x1b	142	44	.	.	.
cord-252230-s1qd3x1b	143	1	Thus	thus	RB
cord-252230-s1qd3x1b	143	2	,	,	,
cord-252230-s1qd3x1b	143	3	viruses	virus	NNS
cord-252230-s1qd3x1b	143	4	subvert	subvert	VBP
cord-252230-s1qd3x1b	143	5	LC3-mediated	lc3-mediated	JJ
cord-252230-s1qd3x1b	143	6	membrane	membrane	NN
cord-252230-s1qd3x1b	143	7	trafficking	trafficking	NN
cord-252230-s1qd3x1b	143	8	events	event	NNS
cord-252230-s1qd3x1b	143	9	through	through	IN
cord-252230-s1qd3x1b	143	10	different	different	JJ
cord-252230-s1qd3x1b	143	11	ways	way	NNS
cord-252230-s1qd3x1b	143	12	.	.	.
cord-252230-s1qd3x1b	144	1	Although	although	IN
cord-252230-s1qd3x1b	144	2	we	-PRON-	PRP
cord-252230-s1qd3x1b	144	3	focus	focus	VBP
cord-252230-s1qd3x1b	144	4	on	on	IN
cord-252230-s1qd3x1b	144	5	strategies	strategy	NNS
cord-252230-s1qd3x1b	144	6	by	by	IN
cord-252230-s1qd3x1b	144	7	which	which	WDT
cord-252230-s1qd3x1b	144	8	viruses	virus	NNS
cord-252230-s1qd3x1b	144	9	coopt	coopt	VBP
cord-252230-s1qd3x1b	144	10	ATGs	atg	NNS
cord-252230-s1qd3x1b	144	11	for	for	IN
cord-252230-s1qd3x1b	144	12	their	-PRON-	PRP$
cord-252230-s1qd3x1b	144	13	own	own	JJ
cord-252230-s1qd3x1b	144	14	benefit	benefit	NN
cord-252230-s1qd3x1b	144	15	,	,	,
cord-252230-s1qd3x1b	144	16	some	some	DT
cord-252230-s1qd3x1b	144	17	viruses	virus	NNS
cord-252230-s1qd3x1b	144	18	are	be	VBP
cord-252230-s1qd3x1b	144	19	restricted	restrict	VBN
cord-252230-s1qd3x1b	144	20	by	by	IN
cord-252230-s1qd3x1b	144	21	autophagy	autophagy	NN
cord-252230-s1qd3x1b	144	22	.	.	.
cord-252230-s1qd3x1b	145	1	For	for	IN
cord-252230-s1qd3x1b	145	2	example	example	NN
cord-252230-s1qd3x1b	145	3	,	,	,
cord-252230-s1qd3x1b	145	4	autophagic	autophagic	JJ
cord-252230-s1qd3x1b	145	5	degradation	degradation	NN
cord-252230-s1qd3x1b	145	6	of	of	IN
cord-252230-s1qd3x1b	145	7	ER	ER	NNP
cord-252230-s1qd3x1b	145	8	,	,	,
cord-252230-s1qd3x1b	145	9	reticulophagy	reticulophagy	NNS
cord-252230-s1qd3x1b	145	10	,	,	,
cord-252230-s1qd3x1b	145	11	restricts	restrict	VBZ
cord-252230-s1qd3x1b	145	12	dengue	dengue	NN
cord-252230-s1qd3x1b	145	13	and	and	CC
cord-252230-s1qd3x1b	145	14	Zika	Zika	NNP
cord-252230-s1qd3x1b	145	15	virus	virus	NN
cord-252230-s1qd3x1b	145	16	replication	replication	NN
cord-252230-s1qd3x1b	145	17	on	on	IN
cord-252230-s1qd3x1b	145	18	ER	ER	NNP
cord-252230-s1qd3x1b	145	19	-	-	HYPH
cord-252230-s1qd3x1b	145	20	derived	derive	VBN
cord-252230-s1qd3x1b	145	21	membranes	membrane	NNS
cord-252230-s1qd3x1b	145	22	.	.	.
cord-252230-s1qd3x1b	146	1	The	the	DT
cord-252230-s1qd3x1b	146	2	NS3	NS3	NNPS
cord-252230-s1qd3x1b	146	3	protease	protease	NN
cord-252230-s1qd3x1b	146	4	encoded	encode	VBN
cord-252230-s1qd3x1b	146	5	by	by	IN
cord-252230-s1qd3x1b	146	6	these	these	DT
cord-252230-s1qd3x1b	146	7	and	and	CC
cord-252230-s1qd3x1b	146	8	other	other	JJ
cord-252230-s1qd3x1b	146	9	flaviviruses	flavivirus	NNS
cord-252230-s1qd3x1b	146	10	counteract	counteract	VBP
cord-252230-s1qd3x1b	146	11	this	this	DT
cord-252230-s1qd3x1b	146	12	inhibition	inhibition	NN
cord-252230-s1qd3x1b	146	13	by	by	IN
cord-252230-s1qd3x1b	146	14	cleaving	cleave	VBG
cord-252230-s1qd3x1b	146	15	the	the	DT
cord-252230-s1qd3x1b	146	16	reticulophagy	reticulophagy	NNS
cord-252230-s1qd3x1b	146	17	receptor	receptor	NN
cord-252230-s1qd3x1b	146	18	FAM134B	FAM134B	NNP
cord-252230-s1qd3x1b	147	1	(	(	-LRB-
cord-252230-s1qd3x1b	147	2	Lennemann	Lennemann	NNP
cord-252230-s1qd3x1b	147	3	and	and	CC
cord-252230-s1qd3x1b	147	4	Coyne	Coyne	NNP
cord-252230-s1qd3x1b	147	5	,	,	,
cord-252230-s1qd3x1b	147	6	2017	2017	CD
cord-252230-s1qd3x1b	147	7	)	)	-RRB-
cord-252230-s1qd3x1b	147	8	.	.	.
cord-252230-s1qd3x1b	148	1	Also	also	RB
cord-252230-s1qd3x1b	148	2	,	,	,
cord-252230-s1qd3x1b	148	3	multiple	multiple	JJ
cord-252230-s1qd3x1b	148	4	herpesviruses	herpesviruse	NNS
cord-252230-s1qd3x1b	148	5	encode	encode	VBP
cord-252230-s1qd3x1b	148	6	proteins	protein	NNS
cord-252230-s1qd3x1b	148	7	that	that	WDT
cord-252230-s1qd3x1b	148	8	bind	bind	VBP
cord-252230-s1qd3x1b	148	9	and	and	CC
cord-252230-s1qd3x1b	148	10	inhibit	inhibit	VBP
cord-252230-s1qd3x1b	148	11	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	148	12	to	to	TO
cord-252230-s1qd3x1b	148	13	avoid	avoid	VB
cord-252230-s1qd3x1b	148	14	autophagy	autophagy	NN
cord-252230-s1qd3x1b	148	15	-	-	HYPH
cord-252230-s1qd3x1b	148	16	mediated	mediate	VBN
cord-252230-s1qd3x1b	148	17	targeting	targeting	NN
cord-252230-s1qd3x1b	148	18	to	to	IN
cord-252230-s1qd3x1b	148	19	the	the	DT
cord-252230-s1qd3x1b	148	20	lysosome	lysosome	NN
cord-252230-s1qd3x1b	148	21	and	and	CC
cord-252230-s1qd3x1b	148	22	antigen	antigen	NN
cord-252230-s1qd3x1b	148	23	presentation	presentation	NN
cord-252230-s1qd3x1b	148	24	to	to	IN
cord-252230-s1qd3x1b	148	25	T	t	NN
cord-252230-s1qd3x1b	148	26	cells	cell	NNS
cord-252230-s1qd3x1b	148	27	(	(	-LRB-
cord-252230-s1qd3x1b	148	28	Deretic	Deretic	NNP
cord-252230-s1qd3x1b	148	29	and	and	CC
cord-252230-s1qd3x1b	148	30	Levine	Levine	NNP
cord-252230-s1qd3x1b	148	31	,	,	,
cord-252230-s1qd3x1b	148	32	2009	2009	CD
cord-252230-s1qd3x1b	148	33	)	)	-RRB-
cord-252230-s1qd3x1b	148	34	.	.	.
cord-252230-s1qd3x1b	149	1	In	in	IN
cord-252230-s1qd3x1b	149	2	other	other	JJ
cord-252230-s1qd3x1b	149	3	situations	situation	NNS
cord-252230-s1qd3x1b	149	4	,	,	,
cord-252230-s1qd3x1b	149	5	it	-PRON-	PRP
cord-252230-s1qd3x1b	149	6	may	may	MD
cord-252230-s1qd3x1b	149	7	be	be	VB
cord-252230-s1qd3x1b	149	8	nonautophagic	nonautophagic	JJ
cord-252230-s1qd3x1b	149	9	functions	function	NNS
cord-252230-s1qd3x1b	149	10	of	of	IN
cord-252230-s1qd3x1b	149	11	ATGs	atg	NNS
cord-252230-s1qd3x1b	149	12	that	that	WDT
cord-252230-s1qd3x1b	149	13	determine	determine	VBP
cord-252230-s1qd3x1b	149	14	virulence	virulence	NN
cord-252230-s1qd3x1b	149	15	,	,	,
cord-252230-s1qd3x1b	149	16	as	as	IN
cord-252230-s1qd3x1b	149	17	suggested	suggest	VBN
cord-252230-s1qd3x1b	149	18	by	by	IN
cord-252230-s1qd3x1b	149	19	an	an	DT
cord-252230-s1qd3x1b	149	20	siRNA	siRNA	NNP
cord-252230-s1qd3x1b	149	21	screen	screen	NN
cord-252230-s1qd3x1b	149	22	comparing	compare	VBG
cord-252230-s1qd3x1b	149	23	the	the	DT
cord-252230-s1qd3x1b	149	24	requirement	requirement	NN
cord-252230-s1qd3x1b	149	25	of	of	IN
cord-252230-s1qd3x1b	149	26	diverse	diverse	JJ
cord-252230-s1qd3x1b	149	27	ATGs	atg	NNS
cord-252230-s1qd3x1b	149	28	during	during	IN
cord-252230-s1qd3x1b	149	29	infection	infection	NN
cord-252230-s1qd3x1b	149	30	by	by	IN
cord-252230-s1qd3x1b	149	31	six	six	CD
cord-252230-s1qd3x1b	149	32	viruses	virus	NNS
cord-252230-s1qd3x1b	150	1	(	(	-LRB-
cord-252230-s1qd3x1b	150	2	Mauthe	Mauthe	NNP
cord-252230-s1qd3x1b	150	3	et	et	FW
cord-252230-s1qd3x1b	150	4	al	al	NNP
cord-252230-s1qd3x1b	150	5	.	.	NNP
cord-252230-s1qd3x1b	150	6	,	,	,
cord-252230-s1qd3x1b	150	7	2016	2016	CD
cord-252230-s1qd3x1b	150	8	)	)	-RRB-
cord-252230-s1qd3x1b	150	9	.	.	.
cord-252230-s1qd3x1b	151	1	This	this	DT
cord-252230-s1qd3x1b	151	2	screen	screen	NN
cord-252230-s1qd3x1b	151	3	revealed	reveal	VBD
cord-252230-s1qd3x1b	151	4	that	that	IN
cord-252230-s1qd3x1b	151	5	many	many	JJ
cord-252230-s1qd3x1b	151	6	of	of	IN
cord-252230-s1qd3x1b	151	7	these	these	DT
cord-252230-s1qd3x1b	151	8	proteins	protein	NNS
cord-252230-s1qd3x1b	151	9	augment	augment	VBP
cord-252230-s1qd3x1b	151	10	or	or	CC
cord-252230-s1qd3x1b	151	11	diminish	diminish	VB
cord-252230-s1qd3x1b	151	12	the	the	DT
cord-252230-s1qd3x1b	151	13	replication	replication	NN
cord-252230-s1qd3x1b	151	14	of	of	IN
cord-252230-s1qd3x1b	151	15	individual	individual	JJ
cord-252230-s1qd3x1b	151	16	viruses	virus	NNS
cord-252230-s1qd3x1b	151	17	independent	independent	JJ
cord-252230-s1qd3x1b	151	18	of	of	IN
cord-252230-s1qd3x1b	151	19	other	other	JJ
cord-252230-s1qd3x1b	151	20	ATGs	atg	NNS
cord-252230-s1qd3x1b	151	21	,	,	,
cord-252230-s1qd3x1b	151	22	consistent	consistent	JJ
cord-252230-s1qd3x1b	151	23	with	with	IN
cord-252230-s1qd3x1b	151	24	the	the	DT
cord-252230-s1qd3x1b	151	25	conclusion	conclusion	NN
cord-252230-s1qd3x1b	151	26	that	that	IN
cord-252230-s1qd3x1b	151	27	nonautophagic	nonautophagic	NNP
cord-252230-s1qd3x1b	151	28	functions	function	NNS
cord-252230-s1qd3x1b	151	29	of	of	IN
cord-252230-s1qd3x1b	151	30	ATGs	atg	NNS
cord-252230-s1qd3x1b	151	31	are	be	VBP
cord-252230-s1qd3x1b	151	32	pervasive	pervasive	JJ
cord-252230-s1qd3x1b	151	33	during	during	IN
cord-252230-s1qd3x1b	151	34	viral	viral	JJ
cord-252230-s1qd3x1b	151	35	infection	infection	NN
cord-252230-s1qd3x1b	151	36	.	.	.
cord-252230-s1qd3x1b	152	1	When	when	WRB
cord-252230-s1qd3x1b	152	2	antimicrobial	antimicrobial	JJ
cord-252230-s1qd3x1b	152	3	immunity	immunity	NN
cord-252230-s1qd3x1b	152	4	is	be	VBZ
cord-252230-s1qd3x1b	152	5	not	not	RB
cord-252230-s1qd3x1b	152	6	xenophagy	xenophagy	NNS
cord-252230-s1qd3x1b	152	7	or	or	CC
cord-252230-s1qd3x1b	152	8	LAP	LAP	NNP
cord-252230-s1qd3x1b	152	9	.	.	.
cord-252230-s1qd3x1b	153	1	Xenophagy	Xenophagy	NNP
cord-252230-s1qd3x1b	153	2	,	,	,
cord-252230-s1qd3x1b	153	3	in	in	IN
cord-252230-s1qd3x1b	153	4	which	which	WDT
cord-252230-s1qd3x1b	153	5	an	an	DT
cord-252230-s1qd3x1b	153	6	internalized	internalize	VBN
cord-252230-s1qd3x1b	153	7	microbe	microbe	NN
cord-252230-s1qd3x1b	153	8	is	be	VBZ
cord-252230-s1qd3x1b	153	9	sequestered	sequester	VBN
cord-252230-s1qd3x1b	153	10	in	in	IN
cord-252230-s1qd3x1b	153	11	an	an	DT
cord-252230-s1qd3x1b	153	12	autophagosome	autophagosome	NN
cord-252230-s1qd3x1b	153	13	and	and	CC
cord-252230-s1qd3x1b	153	14	targeted	target	VBN
cord-252230-s1qd3x1b	153	15	to	to	IN
cord-252230-s1qd3x1b	153	16	the	the	DT
cord-252230-s1qd3x1b	153	17	lysosome	lysosome	NN
cord-252230-s1qd3x1b	153	18	,	,	,
cord-252230-s1qd3x1b	153	19	is	be	VBZ
cord-252230-s1qd3x1b	153	20	an	an	DT
cord-252230-s1qd3x1b	153	21	established	establish	VBN
cord-252230-s1qd3x1b	153	22	form	form	NN
cord-252230-s1qd3x1b	153	23	of	of	IN
cord-252230-s1qd3x1b	153	24	cell	cell	NN
cord-252230-s1qd3x1b	153	25	-	-	HYPH
cord-252230-s1qd3x1b	153	26	autonomous	autonomous	JJ
cord-252230-s1qd3x1b	153	27	defense	defense	NN
cord-252230-s1qd3x1b	153	28	(	(	-LRB-
cord-252230-s1qd3x1b	153	29	Cadwell	Cadwell	NNP
cord-252230-s1qd3x1b	153	30	,	,	,
cord-252230-s1qd3x1b	153	31	2016	2016	CD
cord-252230-s1qd3x1b	153	32	)	)	-RRB-
cord-252230-s1qd3x1b	153	33	.	.	.
cord-252230-s1qd3x1b	154	1	However	however	RB
cord-252230-s1qd3x1b	154	2	,	,	,
cord-252230-s1qd3x1b	154	3	mechanisms	mechanism	NNS
cord-252230-s1qd3x1b	154	4	by	by	IN
cord-252230-s1qd3x1b	154	5	which	which	WDT
cord-252230-s1qd3x1b	154	6	ATGs	atg	NNS
cord-252230-s1qd3x1b	154	7	restrict	restrict	VBP
cord-252230-s1qd3x1b	154	8	intracellular	intracellular	JJ
cord-252230-s1qd3x1b	154	9	pathogens	pathogen	NNS
cord-252230-s1qd3x1b	154	10	are	be	VBP
cord-252230-s1qd3x1b	154	11	sometimes	sometimes	RB
cord-252230-s1qd3x1b	154	12	radically	radically	RB
cord-252230-s1qd3x1b	154	13	different	different	JJ
cord-252230-s1qd3x1b	154	14	from	from	IN
cord-252230-s1qd3x1b	154	15	classic	classic	JJ
cord-252230-s1qd3x1b	154	16	autophagy	autophagy	NN
cord-252230-s1qd3x1b	154	17	or	or	CC
cord-252230-s1qd3x1b	154	18	LAP	lap	NN
cord-252230-s1qd3x1b	154	19	.	.	.
cord-252230-s1qd3x1b	155	1	The	the	DT
cord-252230-s1qd3x1b	155	2	cytokine	cytokine	NN
cord-252230-s1qd3x1b	155	3	IFN	IFN	NNP
cord-252230-s1qd3x1b	155	4	-	-	HYPH
cord-252230-s1qd3x1b	155	5	γ	γ	NNP
cord-252230-s1qd3x1b	155	6	inhibits	inhibit	VBZ
cord-252230-s1qd3x1b	155	7	Toxoplasma	toxoplasma	NN
cord-252230-s1qd3x1b	155	8	gondii	gondii	NN
cord-252230-s1qd3x1b	155	9	replication	replication	NN
cord-252230-s1qd3x1b	155	10	in	in	IN
cord-252230-s1qd3x1b	155	11	macrophages	macrophage	NNS
cord-252230-s1qd3x1b	155	12	by	by	IN
cord-252230-s1qd3x1b	155	13	triggering	trigger	VBG
cord-252230-s1qd3x1b	155	14	a	a	DT
cord-252230-s1qd3x1b	155	15	process	process	NN
cord-252230-s1qd3x1b	155	16	referred	refer	VBN
cord-252230-s1qd3x1b	155	17	to	to	IN
cord-252230-s1qd3x1b	155	18	as	as	IN
cord-252230-s1qd3x1b	155	19	Targeting	target	VBG
cord-252230-s1qd3x1b	155	20	by	by	IN
cord-252230-s1qd3x1b	155	21	AutophaGy	AutophaGy	NNP
cord-252230-s1qd3x1b	155	22	proteins	protein	NNS
cord-252230-s1qd3x1b	155	23	(	(	-LRB-
cord-252230-s1qd3x1b	155	24	TAG	TAG	NNP
cord-252230-s1qd3x1b	155	25	)	)	-RRB-
cord-252230-s1qd3x1b	155	26	,	,	,
cord-252230-s1qd3x1b	155	27	which	which	WDT
cord-252230-s1qd3x1b	155	28	requires	require	VBZ
cord-252230-s1qd3x1b	155	29	ATGs	atg	NNS
cord-252230-s1qd3x1b	155	30	involved	involve	VBN
cord-252230-s1qd3x1b	155	31	in	in	IN
cord-252230-s1qd3x1b	155	32	LC3	lc3	JJ
cord-252230-s1qd3x1b	155	33	conjugation	conjugation	NN
cord-252230-s1qd3x1b	155	34	,	,	,
cord-252230-s1qd3x1b	155	35	but	but	CC
cord-252230-s1qd3x1b	155	36	not	not	RB
cord-252230-s1qd3x1b	155	37	the	the	DT
cord-252230-s1qd3x1b	155	38	lysosome	lysosome	NN
cord-252230-s1qd3x1b	155	39	.	.	.
cord-252230-s1qd3x1b	156	1	Instead	instead	RB
cord-252230-s1qd3x1b	156	2	of	of	IN
cord-252230-s1qd3x1b	156	3	promoting	promote	VBG
cord-252230-s1qd3x1b	156	4	acidification	acidification	NN
cord-252230-s1qd3x1b	156	5	,	,	,
cord-252230-s1qd3x1b	156	6	the	the	DT
cord-252230-s1qd3x1b	156	7	ATG8	ATG8	NNP
cord-252230-s1qd3x1b	156	8	orthologue	orthologue	NN
cord-252230-s1qd3x1b	156	9	GAB	GAB	NNP
cord-252230-s1qd3x1b	156	10	ARA	ARA	NNP
cord-252230-s1qd3x1b	156	11	PL2	PL2	NNP
cord-252230-s1qd3x1b	156	12	(	(	-LRB-
cord-252230-s1qd3x1b	156	13	GATE-16	GATE-16	NNP
cord-252230-s1qd3x1b	156	14	)	)	-RRB-
cord-252230-s1qd3x1b	156	15	recruits	recruit	VBZ
cord-252230-s1qd3x1b	156	16	IFN	IFN	NNP
cord-252230-s1qd3x1b	156	17	-	-	HYPH
cord-252230-s1qd3x1b	156	18	inducible	inducible	JJ
cord-252230-s1qd3x1b	156	19	GTPases	gtpase	NNS
cord-252230-s1qd3x1b	156	20	to	to	IN
cord-252230-s1qd3x1b	156	21	the	the	DT
cord-252230-s1qd3x1b	156	22	parasitophorous	parasitophorous	JJ
cord-252230-s1qd3x1b	156	23	vacuole	vacuole	NN
cord-252230-s1qd3x1b	156	24	where	where	WRB
cord-252230-s1qd3x1b	156	25	they	-PRON-	PRP
cord-252230-s1qd3x1b	156	26	disrupt	disrupt	VBP
cord-252230-s1qd3x1b	156	27	the	the	DT
cord-252230-s1qd3x1b	156	28	membrane	membrane	NN
cord-252230-s1qd3x1b	156	29	and	and	CC
cord-252230-s1qd3x1b	156	30	destroy	destroy	VB
cord-252230-s1qd3x1b	156	31	the	the	DT
cord-252230-s1qd3x1b	156	32	replicative	replicative	JJ
cord-252230-s1qd3x1b	156	33	niche	niche	NN
cord-252230-s1qd3x1b	156	34	of	of	IN
cord-252230-s1qd3x1b	156	35	T.	T.	NNP
cord-252230-s1qd3x1b	156	36	gondii	gondii	NNP
cord-252230-s1qd3x1b	156	37	Park	Park	NNP
cord-252230-s1qd3x1b	156	38	et	et	FW
cord-252230-s1qd3x1b	156	39	al	al	NNP
cord-252230-s1qd3x1b	156	40	.	.	.
cord-252230-s1qd3x1b	157	1	,	,	,
cord-252230-s1qd3x1b	157	2	2016b	2016b	CD
cord-252230-s1qd3x1b	157	3	;	;	:
cord-252230-s1qd3x1b	157	4	Sasai	Sasai	NNP
cord-252230-s1qd3x1b	157	5	et	et	NNP
cord-252230-s1qd3x1b	157	6	al	al	NNP
cord-252230-s1qd3x1b	157	7	.	.	NNP
cord-252230-s1qd3x1b	157	8	,	,	,
cord-252230-s1qd3x1b	157	9	2017	2017	CD
cord-252230-s1qd3x1b	157	10	)	)	-RRB-
cord-252230-s1qd3x1b	157	11	.	.	.
cord-252230-s1qd3x1b	158	1	A	a	DT
cord-252230-s1qd3x1b	158	2	similar	similar	JJ
cord-252230-s1qd3x1b	158	3	mechanism	mechanism	NN
cord-252230-s1qd3x1b	158	4	disrupts	disrupt	VBZ
cord-252230-s1qd3x1b	158	5	the	the	DT
cord-252230-s1qd3x1b	158	6	membranous	membranous	JJ
cord-252230-s1qd3x1b	158	7	structures	structure	NNS
cord-252230-s1qd3x1b	158	8	on	on	IN
cord-252230-s1qd3x1b	158	9	which	which	WDT
cord-252230-s1qd3x1b	158	10	noroviruses	noroviruse	NNS
cord-252230-s1qd3x1b	158	11	replicate	replicate	VBP
cord-252230-s1qd3x1b	158	12	(	(	-LRB-
cord-252230-s1qd3x1b	158	13	Biering	Biering	NNP
cord-252230-s1qd3x1b	158	14	et	et	FW
cord-252230-s1qd3x1b	158	15	al	al	NNP
cord-252230-s1qd3x1b	158	16	.	.	NNP
cord-252230-s1qd3x1b	158	17	,	,	,
cord-252230-s1qd3x1b	158	18	2017	2017	CD
cord-252230-s1qd3x1b	158	19	)	)	-RRB-
cord-252230-s1qd3x1b	158	20	.	.	.
cord-252230-s1qd3x1b	159	1	Additionally	additionally	RB
cord-252230-s1qd3x1b	159	2	,	,	,
cord-252230-s1qd3x1b	159	3	though	though	IN
cord-252230-s1qd3x1b	159	4	xenophagy	xenophagy	NNP
cord-252230-s1qd3x1b	159	5	inhibits	inhibit	VBZ
cord-252230-s1qd3x1b	159	6	Mycobacterium	Mycobacterium	NNP
cord-252230-s1qd3x1b	159	7	tuberculosis	tuberculosis	NN
cord-252230-s1qd3x1b	159	8	replication	replication	NN
cord-252230-s1qd3x1b	159	9	in	in	IN
cord-252230-s1qd3x1b	159	10	cultured	cultured	JJ
cord-252230-s1qd3x1b	159	11	macrophages	macrophage	NNS
cord-252230-s1qd3x1b	159	12	,	,	,
cord-252230-s1qd3x1b	159	13	experiments	experiment	NNS
cord-252230-s1qd3x1b	159	14	using	use	VBG
cord-252230-s1qd3x1b	159	15	cell	cell	NN
cord-252230-s1qd3x1b	159	16	type	type	NN
cord-252230-s1qd3x1b	159	17	-	-	HYPH
cord-252230-s1qd3x1b	159	18	specific	specific	JJ
cord-252230-s1qd3x1b	159	19	knockout	knockout	NN
cord-252230-s1qd3x1b	159	20	mice	mouse	NNS
cord-252230-s1qd3x1b	159	21	revealed	reveal	VBD
cord-252230-s1qd3x1b	159	22	a	a	DT
cord-252230-s1qd3x1b	159	23	surprising	surprising	JJ
cord-252230-s1qd3x1b	159	24	autophagy	autophagy	NN
cord-252230-s1qd3x1b	159	25	-	-	HYPH
cord-252230-s1qd3x1b	159	26	independent	independent	JJ
cord-252230-s1qd3x1b	159	27	function	function	NN
cord-252230-s1qd3x1b	159	28	of	of	IN
cord-252230-s1qd3x1b	159	29	ATG5	ATG5	NNP
cord-252230-s1qd3x1b	159	30	in	in	IN
cord-252230-s1qd3x1b	159	31	neutrophils	neutrophil	NNS
cord-252230-s1qd3x1b	159	32	.	.	.
cord-252230-s1qd3x1b	160	1	Deletion	deletion	NN
cord-252230-s1qd3x1b	160	2	of	of	IN
cord-252230-s1qd3x1b	160	3	ATG5	ATG5	NNP
cord-252230-s1qd3x1b	160	4	,	,	,
cord-252230-s1qd3x1b	160	5	but	but	CC
cord-252230-s1qd3x1b	160	6	not	not	RB
cord-252230-s1qd3x1b	160	7	the	the	DT
cord-252230-s1qd3x1b	160	8	other	other	JJ
cord-252230-s1qd3x1b	160	9	ATGs	atg	NNS
cord-252230-s1qd3x1b	160	10	involved	involve	VBN
cord-252230-s1qd3x1b	160	11	in	in	IN
cord-252230-s1qd3x1b	160	12	LC3	lc3	JJ
cord-252230-s1qd3x1b	160	13	conjugation	conjugation	NN
cord-252230-s1qd3x1b	160	14	,	,	,
cord-252230-s1qd3x1b	160	15	increases	increase	VBZ
cord-252230-s1qd3x1b	160	16	the	the	DT
cord-252230-s1qd3x1b	160	17	amount	amount	NN
cord-252230-s1qd3x1b	160	18	of	of	IN
cord-252230-s1qd3x1b	160	19	neutrophils	neutrophil	NNS
cord-252230-s1qd3x1b	160	20	that	that	WDT
cord-252230-s1qd3x1b	160	21	infiltrate	infiltrate	VBP
cord-252230-s1qd3x1b	160	22	and	and	CC
cord-252230-s1qd3x1b	160	23	damage	damage	VB
cord-252230-s1qd3x1b	160	24	the	the	DT
cord-252230-s1qd3x1b	160	25	lung	lung	NN
cord-252230-s1qd3x1b	160	26	during	during	IN
cord-252230-s1qd3x1b	160	27	Mycobacterium	Mycobacterium	NNP
cord-252230-s1qd3x1b	160	28	tuberculosis	tuberculosis	NN
cord-252230-s1qd3x1b	160	29	infection	infection	NN
cord-252230-s1qd3x1b	161	1	(	(	-LRB-
cord-252230-s1qd3x1b	161	2	Kimmey	Kimmey	NNP
cord-252230-s1qd3x1b	161	3	et	et	NNP
cord-252230-s1qd3x1b	161	4	al	al	NNP
cord-252230-s1qd3x1b	161	5	.	.	NNP
cord-252230-s1qd3x1b	161	6	,	,	,
cord-252230-s1qd3x1b	161	7	2015	2015	CD
cord-252230-s1qd3x1b	161	8	)	)	-RRB-
cord-252230-s1qd3x1b	161	9	.	.	.
cord-252230-s1qd3x1b	162	1	As	as	IN
cord-252230-s1qd3x1b	162	2	with	with	IN
cord-252230-s1qd3x1b	162	3	viruses	virus	NNS
cord-252230-s1qd3x1b	162	4	,	,	,
cord-252230-s1qd3x1b	162	5	bacteria	bacteria	NNS
cord-252230-s1qd3x1b	162	6	can	can	MD
cord-252230-s1qd3x1b	162	7	benefit	benefit	VB
cord-252230-s1qd3x1b	162	8	from	from	IN
cord-252230-s1qd3x1b	162	9	selective	selective	JJ
cord-252230-s1qd3x1b	162	10	components	component	NNS
cord-252230-s1qd3x1b	162	11	of	of	IN
cord-252230-s1qd3x1b	162	12	the	the	DT
cord-252230-s1qd3x1b	162	13	autophagy	autophagy	NN
cord-252230-s1qd3x1b	162	14	machinery	machinery	NN
cord-252230-s1qd3x1b	162	15	.	.	.
cord-252230-s1qd3x1b	163	1	The	the	DT
cord-252230-s1qd3x1b	163	2	multimembrane	multimembrane	NN
cord-252230-s1qd3x1b	163	3	vacuoles	vacuole	NNS
cord-252230-s1qd3x1b	163	4	that	that	WDT
cord-252230-s1qd3x1b	163	5	support	support	VBP
cord-252230-s1qd3x1b	163	6	Brucella	Brucella	NNP
cord-252230-s1qd3x1b	163	7	abortis	abortis	NN
cord-252230-s1qd3x1b	163	8	replication	replication	NN
cord-252230-s1qd3x1b	163	9	are	be	VBP
cord-252230-s1qd3x1b	163	10	generated	generate	VBN
cord-252230-s1qd3x1b	163	11	by	by	IN
cord-252230-s1qd3x1b	163	12	ATGs	atg	NNS
cord-252230-s1qd3x1b	163	13	that	that	WDT
cord-252230-s1qd3x1b	163	14	control	control	VBP
cord-252230-s1qd3x1b	163	15	PI3	pi3	NN
cord-252230-s1qd3x1b	163	16	kinase	kinase	NN
cord-252230-s1qd3x1b	163	17	activity	activity	NN
cord-252230-s1qd3x1b	163	18	(	(	-LRB-
cord-252230-s1qd3x1b	163	19	ULK1	ULK1	NNP
cord-252230-s1qd3x1b	163	20	,	,	,
cord-252230-s1qd3x1b	163	21	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	163	22	,	,	,
cord-252230-s1qd3x1b	163	23	and	and	CC
cord-252230-s1qd3x1b	163	24	ATG14	ATG14	NNP
cord-252230-s1qd3x1b	163	25	)	)	-RRB-
cord-252230-s1qd3x1b	163	26	,	,	,
cord-252230-s1qd3x1b	163	27	but	but	CC
cord-252230-s1qd3x1b	163	28	not	not	RB
cord-252230-s1qd3x1b	163	29	ATGs	atg	NNS
cord-252230-s1qd3x1b	163	30	required	require	VBN
cord-252230-s1qd3x1b	163	31	for	for	IN
cord-252230-s1qd3x1b	163	32	LC3	lc3	JJ
cord-252230-s1qd3x1b	163	33	conjugation	conjugation	NN
cord-252230-s1qd3x1b	163	34	(	(	-LRB-
cord-252230-s1qd3x1b	163	35	ATG7	ATG7	NNP
cord-252230-s1qd3x1b	163	36	,	,	,
cord-252230-s1qd3x1b	163	37	ATG16L1	ATG16L1	NNS
cord-252230-s1qd3x1b	163	38	,	,	,
cord-252230-s1qd3x1b	163	39	ATG5	ATG5	NNP
cord-252230-s1qd3x1b	163	40	,	,	,
cord-252230-s1qd3x1b	163	41	LC3B	lc3b	NN
cord-252230-s1qd3x1b	163	42	,	,	,
cord-252230-s1qd3x1b	163	43	and	and	CC
cord-252230-s1qd3x1b	163	44	ATG4B	atg4b	LS
cord-252230-s1qd3x1b	163	45	)	)	-RRB-
cord-252230-s1qd3x1b	164	1	(	(	-LRB-
cord-252230-s1qd3x1b	164	2	Starr	Starr	NNP
cord-252230-s1qd3x1b	164	3	et	et	NNP
cord-252230-s1qd3x1b	164	4	al	al	NNP
cord-252230-s1qd3x1b	164	5	.	.	NNP
cord-252230-s1qd3x1b	164	6	,	,	,
cord-252230-s1qd3x1b	164	7	2012	2012	CD
cord-252230-s1qd3x1b	164	8	)	)	-RRB-
cord-252230-s1qd3x1b	164	9	.	.	.
cord-252230-s1qd3x1b	165	1	In	in	IN
cord-252230-s1qd3x1b	165	2	addition	addition	NN
cord-252230-s1qd3x1b	165	3	to	to	IN
cord-252230-s1qd3x1b	165	4	these	these	DT
cord-252230-s1qd3x1b	165	5	cellautonomous	cellautonomous	JJ
cord-252230-s1qd3x1b	165	6	functions	function	NNS
cord-252230-s1qd3x1b	165	7	of	of	IN
cord-252230-s1qd3x1b	165	8	ATGs	atg	NNS
cord-252230-s1qd3x1b	165	9	during	during	IN
cord-252230-s1qd3x1b	165	10	infection	infection	NN
cord-252230-s1qd3x1b	165	11	,	,	,
cord-252230-s1qd3x1b	165	12	nonautophagic	nonautophagic	NNP
cord-252230-s1qd3x1b	165	13	ATG	ATG	NNP
cord-252230-s1qd3x1b	165	14	functions	function	NNS
cord-252230-s1qd3x1b	165	15	are	be	VBP
cord-252230-s1qd3x1b	165	16	important	important	JJ
cord-252230-s1qd3x1b	165	17	for	for	IN
cord-252230-s1qd3x1b	165	18	immune	immune	JJ
cord-252230-s1qd3x1b	165	19	signaling	signal	VBG
cord-252230-s1qd3x1b	165	20	pathways	pathway	NNS
cord-252230-s1qd3x1b	165	21	that	that	WDT
cord-252230-s1qd3x1b	165	22	contribute	contribute	VBP
cord-252230-s1qd3x1b	165	23	to	to	IN
cord-252230-s1qd3x1b	165	24	multi	multi	JJ
cord-252230-s1qd3x1b	165	25	-	-	JJ
cord-252230-s1qd3x1b	165	26	cellular	cellular	JJ
cord-252230-s1qd3x1b	165	27	immunity	immunity	NN
cord-252230-s1qd3x1b	165	28	,	,	,
cord-252230-s1qd3x1b	165	29	which	which	WDT
cord-252230-s1qd3x1b	165	30	is	be	VBZ
cord-252230-s1qd3x1b	165	31	discussed	discuss	VBN
cord-252230-s1qd3x1b	165	32	in	in	IN
cord-252230-s1qd3x1b	165	33	the	the	DT
cord-252230-s1qd3x1b	165	34	following	following	JJ
cord-252230-s1qd3x1b	165	35	section	section	NN
cord-252230-s1qd3x1b	165	36	.	.	.
cord-252230-s1qd3x1b	166	1	ATGs	atg	NNS
cord-252230-s1qd3x1b	166	2	have	have	VBP
cord-252230-s1qd3x1b	166	3	a	a	DT
cord-252230-s1qd3x1b	166	4	fundamental	fundamental	JJ
cord-252230-s1qd3x1b	166	5	role	role	NN
cord-252230-s1qd3x1b	166	6	in	in	IN
cord-252230-s1qd3x1b	166	7	suppressing	suppress	VBG
cord-252230-s1qd3x1b	166	8	immune	immune	JJ
cord-252230-s1qd3x1b	166	9	signaling	signaling	NN
cord-252230-s1qd3x1b	166	10	(	(	-LRB-
cord-252230-s1qd3x1b	166	11	Cadwell	Cadwell	NNP
cord-252230-s1qd3x1b	166	12	,	,	,
cord-252230-s1qd3x1b	166	13	2016	2016	CD
cord-252230-s1qd3x1b	166	14	)	)	-RRB-
cord-252230-s1qd3x1b	166	15	.	.	.
cord-252230-s1qd3x1b	167	1	Among	among	IN
cord-252230-s1qd3x1b	167	2	the	the	DT
cord-252230-s1qd3x1b	167	3	first	first	JJ
cord-252230-s1qd3x1b	167	4	indications	indication	NNS
cord-252230-s1qd3x1b	167	5	that	that	WDT
cord-252230-s1qd3x1b	167	6	autophagy	autophagy	NN
cord-252230-s1qd3x1b	167	7	exacts	exact	VBZ
cord-252230-s1qd3x1b	167	8	inhibitory	inhibitory	JJ
cord-252230-s1qd3x1b	167	9	functions	function	NNS
cord-252230-s1qd3x1b	167	10	came	come	VBD
cord-252230-s1qd3x1b	167	11	from	from	IN
cord-252230-s1qd3x1b	167	12	population	population	NN
cord-252230-s1qd3x1b	167	13	genetic	genetic	JJ
cord-252230-s1qd3x1b	167	14	studies	study	NNS
cord-252230-s1qd3x1b	167	15	implicating	implicate	VBG
cord-252230-s1qd3x1b	167	16	a	a	DT
cord-252230-s1qd3x1b	167	17	coding	code	VBG
cord-252230-s1qd3x1b	167	18	variant	variant	NN
cord-252230-s1qd3x1b	167	19	of	of	IN
cord-252230-s1qd3x1b	167	20	ATG16L1	atg16l1	NN
cord-252230-s1qd3x1b	167	21	in	in	IN
cord-252230-s1qd3x1b	167	22	Crohn	Crohn	NNP
cord-252230-s1qd3x1b	167	23	's	's	POS
cord-252230-s1qd3x1b	167	24	disease	disease	NN
cord-252230-s1qd3x1b	167	25	,	,	,
cord-252230-s1qd3x1b	167	26	a	a	DT
cord-252230-s1qd3x1b	167	27	type	type	NN
cord-252230-s1qd3x1b	167	28	of	of	IN
cord-252230-s1qd3x1b	167	29	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	167	30	bowel	bowel	NN
cord-252230-s1qd3x1b	167	31	disease	disease	NN
cord-252230-s1qd3x1b	167	32	(	(	-LRB-
cord-252230-s1qd3x1b	167	33	IBD	IBD	NNP
cord-252230-s1qd3x1b	167	34	)	)	-RRB-
cord-252230-s1qd3x1b	167	35	associated	associate	VBD
cord-252230-s1qd3x1b	167	36	with	with	IN
cord-252230-s1qd3x1b	167	37	an	an	DT
cord-252230-s1qd3x1b	167	38	abnormal	abnormal	JJ
cord-252230-s1qd3x1b	167	39	immune	immune	JJ
cord-252230-s1qd3x1b	167	40	response	response	NN
cord-252230-s1qd3x1b	167	41	to	to	IN
cord-252230-s1qd3x1b	167	42	the	the	DT
cord-252230-s1qd3x1b	167	43	gut	gut	NN
cord-252230-s1qd3x1b	167	44	microbiota	microbiota	NN
cord-252230-s1qd3x1b	167	45	.	.	.
cord-252230-s1qd3x1b	168	1	Consistent	consistent	JJ
cord-252230-s1qd3x1b	168	2	with	with	IN
cord-252230-s1qd3x1b	168	3	this	this	DT
cord-252230-s1qd3x1b	168	4	genetic	genetic	JJ
cord-252230-s1qd3x1b	168	5	association	association	NN
cord-252230-s1qd3x1b	168	6	,	,	,
cord-252230-s1qd3x1b	168	7	ATG16L1	atg16l1	JJ
cord-252230-s1qd3x1b	168	8	deletion	deletion	NN
cord-252230-s1qd3x1b	168	9	causes	cause	VBZ
cord-252230-s1qd3x1b	168	10	macrophages	macrophage	NNS
cord-252230-s1qd3x1b	168	11	to	to	TO
cord-252230-s1qd3x1b	168	12	overproduce	overproduce	VB
cord-252230-s1qd3x1b	168	13	the	the	DT
cord-252230-s1qd3x1b	168	14	cytokine	cytokine	NN
cord-252230-s1qd3x1b	168	15	IL-1β	il-1β	NN
cord-252230-s1qd3x1b	168	16	,	,	,
cord-252230-s1qd3x1b	168	17	which	which	WDT
cord-252230-s1qd3x1b	168	18	mediates	mediate	VBZ
cord-252230-s1qd3x1b	168	19	intestinal	intestinal	JJ
cord-252230-s1qd3x1b	168	20	inflammation	inflammation	NN
cord-252230-s1qd3x1b	168	21	(	(	-LRB-
cord-252230-s1qd3x1b	168	22	Saitoh	Saitoh	NNP
cord-252230-s1qd3x1b	168	23	et	et	FW
cord-252230-s1qd3x1b	168	24	al	al	NNP
cord-252230-s1qd3x1b	168	25	.	.	NNP
cord-252230-s1qd3x1b	168	26	,	,	,
cord-252230-s1qd3x1b	168	27	2008	2008	CD
cord-252230-s1qd3x1b	168	28	)	)	-RRB-
cord-252230-s1qd3x1b	168	29	.	.	.
cord-252230-s1qd3x1b	169	1	Although	although	IN
cord-252230-s1qd3x1b	169	2	increased	increase	VBN
cord-252230-s1qd3x1b	169	3	production	production	NN
cord-252230-s1qd3x1b	169	4	of	of	IN
cord-252230-s1qd3x1b	169	5	immune	immune	JJ
cord-252230-s1qd3x1b	169	6	effectors	effector	NNS
cord-252230-s1qd3x1b	169	7	is	be	VBZ
cord-252230-s1qd3x1b	169	8	pathological	pathological	JJ
cord-252230-s1qd3x1b	169	9	in	in	IN
cord-252230-s1qd3x1b	169	10	this	this	DT
cord-252230-s1qd3x1b	169	11	setting	setting	NN
cord-252230-s1qd3x1b	169	12	,	,	,
cord-252230-s1qd3x1b	169	13	Atg16L1	Atg16L1	NNP
cord-252230-s1qd3x1b	169	14	mutation	mutation	NN
cord-252230-s1qd3x1b	169	15	unexpectedly	unexpectedly	RB
cord-252230-s1qd3x1b	169	16	enhances	enhance	VBZ
cord-252230-s1qd3x1b	169	17	innate	innate	JJ
cord-252230-s1qd3x1b	169	18	immune	immune	JJ
cord-252230-s1qd3x1b	169	19	resistance	resistance	NN
cord-252230-s1qd3x1b	169	20	to	to	IN
cord-252230-s1qd3x1b	169	21	oral	oral	JJ
cord-252230-s1qd3x1b	169	22	infection	infection	NN
cord-252230-s1qd3x1b	169	23	by	by	IN
cord-252230-s1qd3x1b	169	24	the	the	DT
cord-252230-s1qd3x1b	169	25	Gram	gram	NN
cord-252230-s1qd3x1b	169	26	-	-	HYPH
cord-252230-s1qd3x1b	169	27	negative	negative	JJ
cord-252230-s1qd3x1b	169	28	bacterium	bacterium	NN
cord-252230-s1qd3x1b	169	29	Citrobacter	Citrobacter	NNP
cord-252230-s1qd3x1b	169	30	rodentium	rodentium	NN
cord-252230-s1qd3x1b	170	1	(	(	-LRB-
cord-252230-s1qd3x1b	170	2	Marchiando	Marchiando	NNP
cord-252230-s1qd3x1b	170	3	et	et	NNP
cord-252230-s1qd3x1b	170	4	al	al	NNP
cord-252230-s1qd3x1b	170	5	.	.	NNP
cord-252230-s1qd3x1b	170	6	,	,	,
cord-252230-s1qd3x1b	170	7	2013	2013	CD
cord-252230-s1qd3x1b	170	8	)	)	-RRB-
cord-252230-s1qd3x1b	170	9	.	.	.
cord-252230-s1qd3x1b	171	1	Additionally	additionally	RB
cord-252230-s1qd3x1b	171	2	,	,	,
cord-252230-s1qd3x1b	171	3	deletion	deletion	NN
cord-252230-s1qd3x1b	171	4	of	of	IN
cord-252230-s1qd3x1b	171	5	other	other	JJ
cord-252230-s1qd3x1b	171	6	ATGs	atg	NNS
cord-252230-s1qd3x1b	171	7	throughout	throughout	IN
cord-252230-s1qd3x1b	171	8	the	the	DT
cord-252230-s1qd3x1b	171	9	autophagy	autophagy	NN
cord-252230-s1qd3x1b	171	10	pathway	pathway	NN
cord-252230-s1qd3x1b	171	11	leads	lead	VBZ
cord-252230-s1qd3x1b	171	12	to	to	IN
cord-252230-s1qd3x1b	171	13	a	a	DT
cord-252230-s1qd3x1b	171	14	general	general	JJ
cord-252230-s1qd3x1b	171	15	increase	increase	NN
cord-252230-s1qd3x1b	171	16	in	in	IN
cord-252230-s1qd3x1b	171	17	cytokine	cytokine	NN
cord-252230-s1qd3x1b	171	18	levels	level	NNS
cord-252230-s1qd3x1b	171	19	that	that	WDT
cord-252230-s1qd3x1b	171	20	promote	promote	VBP
cord-252230-s1qd3x1b	171	21	resistance	resistance	NN
cord-252230-s1qd3x1b	171	22	to	to	IN
cord-252230-s1qd3x1b	171	23	influenza	influenza	NN
cord-252230-s1qd3x1b	171	24	virus	virus	NN
cord-252230-s1qd3x1b	171	25	infection	infection	NN
cord-252230-s1qd3x1b	171	26	and	and	CC
cord-252230-s1qd3x1b	171	27	inhibition	inhibition	NN
cord-252230-s1qd3x1b	171	28	of	of	IN
cord-252230-s1qd3x1b	171	29	herpesvirus	herpesvirus	NN
cord-252230-s1qd3x1b	171	30	reactivation	reactivation	NN
cord-252230-s1qd3x1b	171	31	from	from	IN
cord-252230-s1qd3x1b	171	32	latency	latency	NNP
cord-252230-s1qd3x1b	171	33	(	(	-LRB-
cord-252230-s1qd3x1b	171	34	Park	Park	NNP
cord-252230-s1qd3x1b	171	35	et	et	FW
cord-252230-s1qd3x1b	171	36	al	al	NNP
cord-252230-s1qd3x1b	171	37	.	.	.
cord-252230-s1qd3x1b	172	1	,	,	,
cord-252230-s1qd3x1b	172	2	2016a	2016a	CD
cord-252230-s1qd3x1b	172	3	)	)	-RRB-
cord-252230-s1qd3x1b	172	4	.	.	.
cord-252230-s1qd3x1b	173	1	In	in	IN
cord-252230-s1qd3x1b	173	2	this	this	DT
cord-252230-s1qd3x1b	173	3	section	section	NN
cord-252230-s1qd3x1b	173	4	,	,	,
cord-252230-s1qd3x1b	173	5	we	-PRON-	PRP
cord-252230-s1qd3x1b	173	6	provide	provide	VBP
cord-252230-s1qd3x1b	173	7	examples	example	NNS
cord-252230-s1qd3x1b	173	8	highlighting	highlight	VBG
cord-252230-s1qd3x1b	173	9	different	different	JJ
cord-252230-s1qd3x1b	173	10	mechanisms	mechanism	NNS
cord-252230-s1qd3x1b	173	11	by	by	IN
cord-252230-s1qd3x1b	173	12	which	which	WDT
cord-252230-s1qd3x1b	173	13	ATGs	atg	NNS
cord-252230-s1qd3x1b	173	14	reduce	reduce	VBP
cord-252230-s1qd3x1b	173	15	signaling	signal	VBG
cord-252230-s1qd3x1b	173	16	downstream	downstream	NN
cord-252230-s1qd3x1b	173	17	of	of	IN
cord-252230-s1qd3x1b	173	18	cytosolic	cytosolic	JJ
cord-252230-s1qd3x1b	173	19	pathogen	pathogen	NN
cord-252230-s1qd3x1b	173	20	sensors	sensor	NNS
cord-252230-s1qd3x1b	173	21	.	.	.
cord-252230-s1qd3x1b	174	1	(	(	-LRB-
cord-252230-s1qd3x1b	174	2	RIG	rig	NN
cord-252230-s1qd3x1b	174	3	-	-	:
cord-252230-s1qd3x1b	174	4	I	i	NN
cord-252230-s1qd3x1b	174	5	)	)	-RRB-
cord-252230-s1qd3x1b	174	6	antiviral	antiviral	JJ
cord-252230-s1qd3x1b	174	7	signaling	signaling	NN
cord-252230-s1qd3x1b	174	8	.	.	.
cord-252230-s1qd3x1b	175	1	The	the	DT
cord-252230-s1qd3x1b	175	2	presence	presence	NN
cord-252230-s1qd3x1b	175	3	of	of	IN
cord-252230-s1qd3x1b	175	4	nucleic	nucleic	JJ
cord-252230-s1qd3x1b	175	5	acid	acid	NN
cord-252230-s1qd3x1b	175	6	in	in	IN
cord-252230-s1qd3x1b	175	7	the	the	DT
cord-252230-s1qd3x1b	175	8	cytoplasm	cytoplasm	NN
cord-252230-s1qd3x1b	175	9	derived	derive	VBN
cord-252230-s1qd3x1b	175	10	from	from	IN
cord-252230-s1qd3x1b	175	11	intracellular	intracellular	JJ
cord-252230-s1qd3x1b	175	12	pathogens	pathogen	NNS
cord-252230-s1qd3x1b	175	13	induces	induce	VBZ
cord-252230-s1qd3x1b	175	14	transcription	transcription	NN
cord-252230-s1qd3x1b	175	15	of	of	IN
cord-252230-s1qd3x1b	175	16	IFN	IFN	NNP
cord-252230-s1qd3x1b	175	17	-	-	HYPH
cord-252230-s1qd3x1b	175	18	I.	I.	NNP
cord-252230-s1qd3x1b	176	1	The	the	DT
cord-252230-s1qd3x1b	176	2	magnitude	magnitude	NN
cord-252230-s1qd3x1b	176	3	of	of	IN
cord-252230-s1qd3x1b	176	4	this	this	DT
cord-252230-s1qd3x1b	176	5	response	response	NN
cord-252230-s1qd3x1b	176	6	is	be	VBZ
cord-252230-s1qd3x1b	176	7	regulated	regulate	VBN
cord-252230-s1qd3x1b	176	8	by	by	IN
cord-252230-s1qd3x1b	176	9	ATGs	atg	NNS
cord-252230-s1qd3x1b	176	10	through	through	IN
cord-252230-s1qd3x1b	176	11	both	both	DT
cord-252230-s1qd3x1b	176	12	autophagy	autophagy	NN
cord-252230-s1qd3x1b	176	13	-	-	HYPH
cord-252230-s1qd3x1b	176	14	dependent	dependent	JJ
cord-252230-s1qd3x1b	176	15	and	and	CC
cord-252230-s1qd3x1b	176	16	-independent	-independent	JJ
cord-252230-s1qd3x1b	176	17	mechanisms	mechanism	NNS
cord-252230-s1qd3x1b	176	18	.	.	.
cord-252230-s1qd3x1b	177	1	RIG	rig	NN
cord-252230-s1qd3x1b	177	2	-	-	:
cord-252230-s1qd3x1b	177	3	I	-PRON-	PRP
cord-252230-s1qd3x1b	177	4	binds	bind	VBZ
cord-252230-s1qd3x1b	177	5	short	short	JJ
cord-252230-s1qd3x1b	177	6	double	double	RB
cord-252230-s1qd3x1b	177	7	-	-	HYPH
cord-252230-s1qd3x1b	177	8	stranded	strand	VBN
cord-252230-s1qd3x1b	177	9	RNA	RNA	NNP
cord-252230-s1qd3x1b	177	10	with	with	IN
cord-252230-s1qd3x1b	177	11	a	a	DT
cord-252230-s1qd3x1b	177	12	5′ppp	5′ppp	CD
cord-252230-s1qd3x1b	177	13	moiety	moiety	NN
cord-252230-s1qd3x1b	177	14	,	,	,
cord-252230-s1qd3x1b	177	15	which	which	WDT
cord-252230-s1qd3x1b	177	16	exposes	expose	VBZ
cord-252230-s1qd3x1b	177	17	the	the	DT
cord-252230-s1qd3x1b	177	18	caspase	caspase	NN
cord-252230-s1qd3x1b	177	19	activation	activation	NN
cord-252230-s1qd3x1b	177	20	and	and	CC
cord-252230-s1qd3x1b	177	21	recruitment	recruitment	NN
cord-252230-s1qd3x1b	177	22	domain	domain	NN
cord-252230-s1qd3x1b	177	23	(	(	-LRB-
cord-252230-s1qd3x1b	177	24	CARD	card	NN
cord-252230-s1qd3x1b	177	25	)	)	-RRB-
cord-252230-s1qd3x1b	177	26	to	to	TO
cord-252230-s1qd3x1b	177	27	allow	allow	VB
cord-252230-s1qd3x1b	177	28	interaction	interaction	NN
cord-252230-s1qd3x1b	177	29	with	with	IN
cord-252230-s1qd3x1b	177	30	the	the	DT
cord-252230-s1qd3x1b	177	31	CARD	card	NN
cord-252230-s1qd3x1b	177	32	of	of	IN
cord-252230-s1qd3x1b	177	33	mitochondrial	mitochondrial	JJ
cord-252230-s1qd3x1b	177	34	antiviral	antiviral	JJ
cord-252230-s1qd3x1b	177	35	signaling	signal	VBG
cord-252230-s1qd3x1b	177	36	protein	protein	NN
cord-252230-s1qd3x1b	177	37	(	(	-LRB-
cord-252230-s1qd3x1b	177	38	MAVS	mavs	RB
cord-252230-s1qd3x1b	177	39	;	;	:
cord-252230-s1qd3x1b	177	40	Yoneyama	Yoneyama	NNP
cord-252230-s1qd3x1b	177	41	et	et	NNP
cord-252230-s1qd3x1b	177	42	al	al	NNP
cord-252230-s1qd3x1b	177	43	.	.	NNP
cord-252230-s1qd3x1b	177	44	,	,	,
cord-252230-s1qd3x1b	177	45	2004	2004	CD
cord-252230-s1qd3x1b	177	46	;	;	:
cord-252230-s1qd3x1b	177	47	Kawai	Kawai	NNP
cord-252230-s1qd3x1b	177	48	et	et	NNP
cord-252230-s1qd3x1b	177	49	al	al	NNP
cord-252230-s1qd3x1b	177	50	.	.	NNP
cord-252230-s1qd3x1b	177	51	,	,	,
cord-252230-s1qd3x1b	177	52	2005	2005	CD
cord-252230-s1qd3x1b	177	53	;	;	:
cord-252230-s1qd3x1b	178	1	Meylan	Meylan	NNP
cord-252230-s1qd3x1b	178	2	et	et	NNP
cord-252230-s1qd3x1b	178	3	al	al	NNP
cord-252230-s1qd3x1b	178	4	.	.	NNP
cord-252230-s1qd3x1b	178	5	,	,	,
cord-252230-s1qd3x1b	178	6	2005	2005	CD
cord-252230-s1qd3x1b	178	7	;	;	:
cord-252230-s1qd3x1b	178	8	Seth	Seth	NNP
cord-252230-s1qd3x1b	178	9	et	et	NNP
cord-252230-s1qd3x1b	178	10	al	al	NNP
cord-252230-s1qd3x1b	178	11	.	.	NNP
cord-252230-s1qd3x1b	178	12	,	,	,
cord-252230-s1qd3x1b	178	13	2005	2005	CD
cord-252230-s1qd3x1b	178	14	)	)	-RRB-
cord-252230-s1qd3x1b	178	15	.	.	.
cord-252230-s1qd3x1b	179	1	After	after	IN
cord-252230-s1qd3x1b	179	2	this	this	DT
cord-252230-s1qd3x1b	179	3	CARD	card	NN
cord-252230-s1qd3x1b	179	4	-	-	HYPH
cord-252230-s1qd3x1b	179	5	CARD	card	NN
cord-252230-s1qd3x1b	179	6	interaction	interaction	NN
cord-252230-s1qd3x1b	179	7	,	,	,
cord-252230-s1qd3x1b	179	8	MAVS	MAVS	NNP
cord-252230-s1qd3x1b	179	9	oligomerizes	oligomerize	NNS
cord-252230-s1qd3x1b	179	10	on	on	IN
cord-252230-s1qd3x1b	179	11	the	the	DT
cord-252230-s1qd3x1b	179	12	mitochondrial	mitochondrial	JJ
cord-252230-s1qd3x1b	179	13	outer	outer	JJ
cord-252230-s1qd3x1b	179	14	surface	surface	NN
cord-252230-s1qd3x1b	179	15	to	to	TO
cord-252230-s1qd3x1b	179	16	activate	activate	VB
cord-252230-s1qd3x1b	179	17	TBK-1	TBK-1	NNP
cord-252230-s1qd3x1b	179	18	,	,	,
cord-252230-s1qd3x1b	179	19	which	which	WDT
cord-252230-s1qd3x1b	179	20	in	in	IN
cord-252230-s1qd3x1b	179	21	turn	turn	NN
cord-252230-s1qd3x1b	179	22	leads	lead	VBZ
cord-252230-s1qd3x1b	179	23	to	to	IN
cord-252230-s1qd3x1b	179	24	the	the	DT
cord-252230-s1qd3x1b	179	25	phosphorylation	phosphorylation	NN
cord-252230-s1qd3x1b	179	26	and	and	CC
cord-252230-s1qd3x1b	179	27	nuclear	nuclear	JJ
cord-252230-s1qd3x1b	179	28	translocation	translocation	NN
cord-252230-s1qd3x1b	179	29	of	of	IN
cord-252230-s1qd3x1b	179	30	the	the	DT
cord-252230-s1qd3x1b	179	31	transcription	transcription	NN
cord-252230-s1qd3x1b	179	32	factors	factor	NNS
cord-252230-s1qd3x1b	179	33	IFN	IFN	NNP
cord-252230-s1qd3x1b	179	34	regulatory	regulatory	JJ
cord-252230-s1qd3x1b	179	35	factor	factor	NN
cord-252230-s1qd3x1b	179	36	3	3	CD
cord-252230-s1qd3x1b	179	37	(	(	-LRB-
cord-252230-s1qd3x1b	179	38	IRF3	IRF3	NNP
cord-252230-s1qd3x1b	179	39	)	)	-RRB-
cord-252230-s1qd3x1b	179	40	,	,	,
cord-252230-s1qd3x1b	179	41	IRF7	IRF7	NNP
cord-252230-s1qd3x1b	179	42	,	,	,
cord-252230-s1qd3x1b	179	43	and	and	CC
cord-252230-s1qd3x1b	179	44	NFκb	NFκb	NNP
cord-252230-s1qd3x1b	179	45	(	(	-LRB-
cord-252230-s1qd3x1b	179	46	Honda	Honda	NNP
cord-252230-s1qd3x1b	179	47	et	et	NNP
cord-252230-s1qd3x1b	179	48	al	al	NNP
cord-252230-s1qd3x1b	179	49	.	.	NNP
cord-252230-s1qd3x1b	179	50	,	,	,
cord-252230-s1qd3x1b	179	51	2005	2005	CD
cord-252230-s1qd3x1b	179	52	;	;	:
cord-252230-s1qd3x1b	180	1	Seth	Seth	NNP
cord-252230-s1qd3x1b	180	2	et	et	NNP
cord-252230-s1qd3x1b	180	3	al	al	NNP
cord-252230-s1qd3x1b	180	4	.	.	NNP
cord-252230-s1qd3x1b	180	5	,	,	,
cord-252230-s1qd3x1b	180	6	2005	2005	CD
cord-252230-s1qd3x1b	180	7	)	)	-RRB-
cord-252230-s1qd3x1b	180	8	.	.	.
cord-252230-s1qd3x1b	181	1	The	the	DT
cord-252230-s1qd3x1b	181	2	ATG5-ATG12	ATG5-ATG12	NNP
cord-252230-s1qd3x1b	181	3	conjugate	conjugate	NN
cord-252230-s1qd3x1b	181	4	inhibits	inhibit	VBZ
cord-252230-s1qd3x1b	181	5	this	this	DT
cord-252230-s1qd3x1b	181	6	RNA	RNA	NNP
cord-252230-s1qd3x1b	181	7	recognition	recognition	NN
cord-252230-s1qd3x1b	181	8	pathway	pathway	NN
cord-252230-s1qd3x1b	181	9	by	by	IN
cord-252230-s1qd3x1b	181	10	binding	bind	VBG
cord-252230-s1qd3x1b	181	11	the	the	DT
cord-252230-s1qd3x1b	181	12	CARDs	card	NNS
cord-252230-s1qd3x1b	181	13	of	of	IN
cord-252230-s1qd3x1b	181	14	RIG	rig	NN
cord-252230-s1qd3x1b	181	15	-	-	:
cord-252230-s1qd3x1b	181	16	I	-PRON-	PRP
cord-252230-s1qd3x1b	181	17	and	and	CC
cord-252230-s1qd3x1b	181	18	MAVS	MAVS	NNP
cord-252230-s1qd3x1b	182	1	(	(	-LRB-
cord-252230-s1qd3x1b	182	2	Fig	Fig	NNP
cord-252230-s1qd3x1b	182	3	.	.	.
cord-252230-s1qd3x1b	183	1	3	3	LS
cord-252230-s1qd3x1b	183	2	;	;	:
cord-252230-s1qd3x1b	183	3	Jounai	Jounai	NNP
cord-252230-s1qd3x1b	183	4	et	et	NNP
cord-252230-s1qd3x1b	183	5	al	al	NNP
cord-252230-s1qd3x1b	183	6	.	.	NNP
cord-252230-s1qd3x1b	183	7	,	,	,
cord-252230-s1qd3x1b	183	8	2007	2007	CD
cord-252230-s1qd3x1b	183	9	)	)	-RRB-
cord-252230-s1qd3x1b	183	10	.	.	.
cord-252230-s1qd3x1b	184	1	Although	although	IN
cord-252230-s1qd3x1b	184	2	it	-PRON-	PRP
cord-252230-s1qd3x1b	184	3	is	be	VBZ
cord-252230-s1qd3x1b	184	4	unclear	unclear	JJ
cord-252230-s1qd3x1b	184	5	how	how	WRB
cord-252230-s1qd3x1b	184	6	these	these	DT
cord-252230-s1qd3x1b	184	7	interactions	interaction	NNS
cord-252230-s1qd3x1b	184	8	prevent	prevent	VBP
cord-252230-s1qd3x1b	184	9	MAVS	MAVS	NNPS
cord-252230-s1qd3x1b	184	10	function	function	VBP
cord-252230-s1qd3x1b	184	11	,	,	,
cord-252230-s1qd3x1b	184	12	the	the	DT
cord-252230-s1qd3x1b	184	13	direct	direct	JJ
cord-252230-s1qd3x1b	184	14	binding	binding	NN
cord-252230-s1qd3x1b	184	15	of	of	IN
cord-252230-s1qd3x1b	184	16	ATG5-ATG12	ATG5-ATG12	NNP
cord-252230-s1qd3x1b	184	17	to	to	IN
cord-252230-s1qd3x1b	184	18	CARDs	card	NNS
cord-252230-s1qd3x1b	184	19	suggests	suggest	VBZ
cord-252230-s1qd3x1b	184	20	that	that	IN
cord-252230-s1qd3x1b	184	21	the	the	DT
cord-252230-s1qd3x1b	184	22	mechanism	mechanism	NN
cord-252230-s1qd3x1b	184	23	is	be	VBZ
cord-252230-s1qd3x1b	184	24	autophagy	autophagy	NN
cord-252230-s1qd3x1b	184	25	-	-	HYPH
cord-252230-s1qd3x1b	184	26	independent	independent	JJ
cord-252230-s1qd3x1b	184	27	.	.	.
cord-252230-s1qd3x1b	185	1	An	an	DT
cord-252230-s1qd3x1b	185	2	alternative	alternative	JJ
cord-252230-s1qd3x1b	185	3	mechanism	mechanism	NN
cord-252230-s1qd3x1b	185	4	involves	involve	VBZ
cord-252230-s1qd3x1b	185	5	increased	increase	VBN
cord-252230-s1qd3x1b	185	6	IFN	IFN	NNP
cord-252230-s1qd3x1b	185	7	-	-	HYPH
cord-252230-s1qd3x1b	185	8	I	-PRON-	PRP
cord-252230-s1qd3x1b	185	9	production	production	NN
cord-252230-s1qd3x1b	185	10	upon	upon	IN
cord-252230-s1qd3x1b	185	11	disruption	disruption	NN
cord-252230-s1qd3x1b	185	12	of	of	IN
cord-252230-s1qd3x1b	185	13	mitophagy	mitophagy	NNS
cord-252230-s1qd3x1b	185	14	.	.	.
cord-252230-s1qd3x1b	186	1	ROS	ROS	NNP
cord-252230-s1qd3x1b	186	2	from	from	IN
cord-252230-s1qd3x1b	186	3	damaged	damaged	JJ
cord-252230-s1qd3x1b	186	4	mitochondria	mitochondrion	NNS
cord-252230-s1qd3x1b	186	5	accumulate	accumulate	VBP
cord-252230-s1qd3x1b	186	6	upon	upon	IN
cord-252230-s1qd3x1b	186	7	ATG5	atg5	JJ
cord-252230-s1qd3x1b	186	8	deletion	deletion	NN
cord-252230-s1qd3x1b	186	9	,	,	,
cord-252230-s1qd3x1b	186	10	which	which	WDT
cord-252230-s1qd3x1b	186	11	enhances	enhance	VBZ
cord-252230-s1qd3x1b	186	12	RIG	rig	NN
cord-252230-s1qd3x1b	186	13	-	-	:
cord-252230-s1qd3x1b	186	14	I	i	NN
cord-252230-s1qd3x1b	186	15	signaling	signal	VBG
cord-252230-s1qd3x1b	186	16	(	(	-LRB-
cord-252230-s1qd3x1b	186	17	Fig	Fig	NNP
cord-252230-s1qd3x1b	186	18	.	.	.
cord-252230-s1qd3x1b	186	19	3	3	CD
cord-252230-s1qd3x1b	186	20	;	;	:
cord-252230-s1qd3x1b	186	21	Tal	Tal	NNP
cord-252230-s1qd3x1b	186	22	et	et	FW
cord-252230-s1qd3x1b	186	23	al	al	NNP
cord-252230-s1qd3x1b	186	24	.	.	NNP
cord-252230-s1qd3x1b	186	25	,	,	,
cord-252230-s1qd3x1b	186	26	2009	2009	CD
cord-252230-s1qd3x1b	186	27	)	)	-RRB-
cord-252230-s1qd3x1b	186	28	.	.	.
cord-252230-s1qd3x1b	187	1	Mitophagy	Mitophagy	NNP
cord-252230-s1qd3x1b	187	2	also	also	RB
cord-252230-s1qd3x1b	187	3	mediates	mediate	VBZ
cord-252230-s1qd3x1b	187	4	the	the	DT
cord-252230-s1qd3x1b	187	5	concurrent	concurrent	JJ
cord-252230-s1qd3x1b	187	6	degradation	degradation	NN
cord-252230-s1qd3x1b	187	7	of	of	IN
cord-252230-s1qd3x1b	187	8	MAVS	MAVS	NNPS
cord-252230-s1qd3x1b	187	9	upon	upon	IN
cord-252230-s1qd3x1b	187	10	its	-PRON-	PRP$
cord-252230-s1qd3x1b	187	11	translocation	translocation	NN
cord-252230-s1qd3x1b	187	12	to	to	IN
cord-252230-s1qd3x1b	187	13	mitochondria	mitochondrion	NNS
cord-252230-s1qd3x1b	187	14	.	.	.
cord-252230-s1qd3x1b	188	1	The	the	DT
cord-252230-s1qd3x1b	188	2	recruitment	recruitment	NN
cord-252230-s1qd3x1b	188	3	of	of	IN
cord-252230-s1qd3x1b	188	4	the	the	DT
cord-252230-s1qd3x1b	188	5	ATG16L1-ATG5-ATG12	ATG16L1-ATG5-ATG12	NNP
cord-252230-s1qd3x1b	188	6	complex	complex	NN
cord-252230-s1qd3x1b	188	7	to	to	IN
cord-252230-s1qd3x1b	188	8	mitochondria	mitochondrion	NNS
cord-252230-s1qd3x1b	188	9	by	by	IN
cord-252230-s1qd3x1b	188	10	NLRX1	NLRX1	NNP
cord-252230-s1qd3x1b	188	11	and	and	CC
cord-252230-s1qd3x1b	188	12	elongation	elongation	NN
cord-252230-s1qd3x1b	188	13	factor	factor	NN
cord-252230-s1qd3x1b	188	14	Tu	Tu	NNP
cord-252230-s1qd3x1b	188	15	(	(	-LRB-
cord-252230-s1qd3x1b	188	16	TUFM	TUFM	NNP
cord-252230-s1qd3x1b	188	17	)	)	-RRB-
cord-252230-s1qd3x1b	188	18	decreases	decrease	VBZ
cord-252230-s1qd3x1b	188	19	MAVS	MAVS	NNP
cord-252230-s1qd3x1b	188	20	activity	activity	NN
cord-252230-s1qd3x1b	188	21	(	(	-LRB-
cord-252230-s1qd3x1b	188	22	Fig	Fig	NNP
cord-252230-s1qd3x1b	188	23	.	.	.
cord-252230-s1qd3x1b	188	24	3	3	CD
cord-252230-s1qd3x1b	188	25	;	;	:
cord-252230-s1qd3x1b	188	26	Lei	Lei	NNP
cord-252230-s1qd3x1b	188	27	et	et	FW
cord-252230-s1qd3x1b	188	28	al	al	NNP
cord-252230-s1qd3x1b	188	29	.	.	NNP
cord-252230-s1qd3x1b	188	30	,	,	,
cord-252230-s1qd3x1b	188	31	2012	2012	CD
cord-252230-s1qd3x1b	188	32	)	)	-RRB-
cord-252230-s1qd3x1b	188	33	.	.	.
cord-252230-s1qd3x1b	189	1	The	the	DT
cord-252230-s1qd3x1b	189	2	importance	importance	NN
cord-252230-s1qd3x1b	189	3	of	of	IN
cord-252230-s1qd3x1b	189	4	this	this	DT
cord-252230-s1qd3x1b	189	5	pathway	pathway	NN
cord-252230-s1qd3x1b	189	6	is	be	VBZ
cord-252230-s1qd3x1b	189	7	highlighted	highlight	VBN
cord-252230-s1qd3x1b	189	8	by	by	IN
cord-252230-s1qd3x1b	189	9	the	the	DT
cord-252230-s1qd3x1b	189	10	observation	observation	NN
cord-252230-s1qd3x1b	189	11	that	that	IN
cord-252230-s1qd3x1b	189	12	the	the	DT
cord-252230-s1qd3x1b	189	13	human	human	JJ
cord-252230-s1qd3x1b	189	14	parainfluenza	parainfluenza	NNP
cord-252230-s1qd3x1b	189	15	virus	virus	NNP
cord-252230-s1qd3x1b	189	16	type	type	NNP
cord-252230-s1qd3x1b	189	17	3	3	CD
cord-252230-s1qd3x1b	189	18	matrix	matrix	NN
cord-252230-s1qd3x1b	189	19	protein	protein	NN
cord-252230-s1qd3x1b	189	20	induces	induce	VBZ
cord-252230-s1qd3x1b	189	21	mitophagy	mitophagy	NN
cord-252230-s1qd3x1b	189	22	through	through	IN
cord-252230-s1qd3x1b	189	23	interaction	interaction	NN
cord-252230-s1qd3x1b	189	24	with	with	IN
cord-252230-s1qd3x1b	189	25	TUFM	TUFM	NNP
cord-252230-s1qd3x1b	189	26	,	,	,
cord-252230-s1qd3x1b	189	27	leading	lead	VBG
cord-252230-s1qd3x1b	189	28	to	to	IN
cord-252230-s1qd3x1b	189	29	decreased	decrease	VBN
cord-252230-s1qd3x1b	189	30	immune	immune	JJ
cord-252230-s1qd3x1b	189	31	signaling	signaling	NN
cord-252230-s1qd3x1b	189	32	and	and	CC
cord-252230-s1qd3x1b	189	33	increased	increase	VBN
cord-252230-s1qd3x1b	189	34	viral	viral	JJ
cord-252230-s1qd3x1b	189	35	replication	replication	NN
cord-252230-s1qd3x1b	189	36	(	(	-LRB-
cord-252230-s1qd3x1b	189	37	Ding	Ding	NNP
cord-252230-s1qd3x1b	189	38	et	et	FW
cord-252230-s1qd3x1b	189	39	al	al	NNP
cord-252230-s1qd3x1b	189	40	.	.	NNP
cord-252230-s1qd3x1b	189	41	,	,	,
cord-252230-s1qd3x1b	189	42	2017	2017	CD
cord-252230-s1qd3x1b	189	43	)	)	-RRB-
cord-252230-s1qd3x1b	189	44	.	.	.
cord-252230-s1qd3x1b	190	1	Also	also	RB
cord-252230-s1qd3x1b	190	2	,	,	,
cord-252230-s1qd3x1b	190	3	a	a	DT
cord-252230-s1qd3x1b	190	4	single	single	JJ
cord-252230-s1qd3x1b	190	5	base	base	NN
cord-252230-s1qd3x1b	190	6	substitution	substitution	NN
cord-252230-s1qd3x1b	190	7	that	that	WDT
cord-252230-s1qd3x1b	190	8	confers	confer	VBZ
cord-252230-s1qd3x1b	190	9	the	the	DT
cord-252230-s1qd3x1b	190	10	ability	ability	NN
cord-252230-s1qd3x1b	190	11	of	of	IN
cord-252230-s1qd3x1b	190	12	the	the	DT
cord-252230-s1qd3x1b	190	13	viral	viral	JJ
cord-252230-s1qd3x1b	190	14	polymerase	polymerase	NN
cord-252230-s1qd3x1b	190	15	basic	basic	JJ
cord-252230-s1qd3x1b	190	16	protein	protein	NN
cord-252230-s1qd3x1b	190	17	2	2	CD
cord-252230-s1qd3x1b	190	18	to	to	TO
cord-252230-s1qd3x1b	190	19	bind	bind	VB
cord-252230-s1qd3x1b	190	20	TUFM	TUFM	NNP
cord-252230-s1qd3x1b	190	21	and	and	CC
cord-252230-s1qd3x1b	190	22	induce	induce	VB
cord-252230-s1qd3x1b	190	23	autophagy	autophagy	NN
cord-252230-s1qd3x1b	190	24	allows	allow	VBZ
cord-252230-s1qd3x1b	190	25	avian	avian	JJ
cord-252230-s1qd3x1b	190	26	influenza	influenza	NN
cord-252230-s1qd3x1b	190	27	virus	virus	NN
cord-252230-s1qd3x1b	190	28	to	to	TO
cord-252230-s1qd3x1b	190	29	infect	infect	VB
cord-252230-s1qd3x1b	190	30	human	human	JJ
cord-252230-s1qd3x1b	190	31	cells	cell	NNS
cord-252230-s1qd3x1b	190	32	(	(	-LRB-
cord-252230-s1qd3x1b	190	33	Kuo	Kuo	NNP
cord-252230-s1qd3x1b	190	34	et	et	NNP
cord-252230-s1qd3x1b	190	35	al	al	NNP
cord-252230-s1qd3x1b	190	36	.	.	NNP
cord-252230-s1qd3x1b	190	37	,	,	,
cord-252230-s1qd3x1b	190	38	2017	2017	CD
cord-252230-s1qd3x1b	190	39	)	)	-RRB-
cord-252230-s1qd3x1b	190	40	.	.	.
cord-252230-s1qd3x1b	191	1	Most	most	RBS
cord-252230-s1qd3x1b	191	2	likely	likely	JJ
cord-252230-s1qd3x1b	191	3	through	through	IN
cord-252230-s1qd3x1b	191	4	a	a	DT
cord-252230-s1qd3x1b	191	5	similar	similar	JJ
cord-252230-s1qd3x1b	191	6	process	process	NN
cord-252230-s1qd3x1b	191	7	,	,	,
cord-252230-s1qd3x1b	191	8	the	the	DT
cord-252230-s1qd3x1b	191	9	mitochondrial	mitochondrial	JJ
cord-252230-s1qd3x1b	191	10	protein	protein	NN
cord-252230-s1qd3x1b	191	11	COX5B	COX5B	NNS
cord-252230-s1qd3x1b	191	12	binds	bind	VBZ
cord-252230-s1qd3x1b	191	13	ATG5	ATG5	NNP
cord-252230-s1qd3x1b	191	14	and	and	CC
cord-252230-s1qd3x1b	191	15	MAVS	MAVS	NNP
cord-252230-s1qd3x1b	191	16	,	,	,
cord-252230-s1qd3x1b	191	17	and	and	CC
cord-252230-s1qd3x1b	191	18	reduces	reduce	VBZ
cord-252230-s1qd3x1b	191	19	ROS	ROS	NNP
cord-252230-s1qd3x1b	191	20	and	and	CC
cord-252230-s1qd3x1b	192	1	IFN	IFN	NNP
cord-252230-s1qd3x1b	192	2	-	-	HYPH
cord-252230-s1qd3x1b	192	3	I	-PRON-	PRP
cord-252230-s1qd3x1b	192	4	production	production	NN
cord-252230-s1qd3x1b	192	5	during	during	IN
cord-252230-s1qd3x1b	192	6	viral	viral	JJ
cord-252230-s1qd3x1b	192	7	infection	infection	NN
cord-252230-s1qd3x1b	193	1	(	(	-LRB-
cord-252230-s1qd3x1b	193	2	Zhao	Zhao	NNP
cord-252230-s1qd3x1b	193	3	et	et	NNP
cord-252230-s1qd3x1b	193	4	al	al	NNP
cord-252230-s1qd3x1b	193	5	.	.	NNP
cord-252230-s1qd3x1b	193	6	,	,	,
cord-252230-s1qd3x1b	193	7	2012	2012	CD
cord-252230-s1qd3x1b	193	8	)	)	-RRB-
cord-252230-s1qd3x1b	193	9	.	.	.
cord-252230-s1qd3x1b	194	1	The	the	DT
cord-252230-s1qd3x1b	194	2	commonality	commonality	NN
cord-252230-s1qd3x1b	194	3	in	in	IN
cord-252230-s1qd3x1b	194	4	these	these	DT
cord-252230-s1qd3x1b	194	5	studies	study	NNS
cord-252230-s1qd3x1b	194	6	is	be	VBZ
cord-252230-s1qd3x1b	194	7	that	that	IN
cord-252230-s1qd3x1b	194	8	inhibiting	inhibit	VBG
cord-252230-s1qd3x1b	194	9	the	the	DT
cord-252230-s1qd3x1b	194	10	ATG5-ATG12	ATG5-ATG12	NNP
cord-252230-s1qd3x1b	194	11	conjugate	conjugate	NN
cord-252230-s1qd3x1b	194	12	increases	increase	VBZ
cord-252230-s1qd3x1b	194	13	IFN	IFN	NNP
cord-252230-s1qd3x1b	194	14	-	-	HYPH
cord-252230-s1qd3x1b	194	15	I	I	NNP
cord-252230-s1qd3x1b	194	16	and	and	CC
cord-252230-s1qd3x1b	194	17	decreases	decrease	VBZ
cord-252230-s1qd3x1b	194	18	replication	replication	NN
cord-252230-s1qd3x1b	194	19	of	of	IN
cord-252230-s1qd3x1b	194	20	RNA	RNA	NNP
cord-252230-s1qd3x1b	194	21	viruses	virus	NNS
cord-252230-s1qd3x1b	194	22	.	.	.
cord-252230-s1qd3x1b	194	23	.	.	.
cord-252230-s1qd3x1b	195	1	ATGs	atg	NNS
cord-252230-s1qd3x1b	195	2	in	in	IN
cord-252230-s1qd3x1b	195	3	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	195	4	and	and	CC
cord-252230-s1qd3x1b	195	5	immune	immune	JJ
cord-252230-s1qd3x1b	195	6	signaling	signaling	NN
cord-252230-s1qd3x1b	195	7	.	.	.
cord-252230-s1qd3x1b	196	1	ATGs	atg	NNS
cord-252230-s1qd3x1b	196	2	regulate	regulate	VBP
cord-252230-s1qd3x1b	196	3	immune	immune	JJ
cord-252230-s1qd3x1b	196	4	signaling	signal	VBG
cord-252230-s1qd3x1b	196	5	cascades	cascade	NNS
cord-252230-s1qd3x1b	196	6	through	through	IN
cord-252230-s1qd3x1b	196	7	autophagy	autophagy	NN
cord-252230-s1qd3x1b	196	8	-	-	HYPH
cord-252230-s1qd3x1b	196	9	dependent	dependent	JJ
cord-252230-s1qd3x1b	196	10	and	and	CC
cord-252230-s1qd3x1b	196	11	-independent	-independent	JJ
cord-252230-s1qd3x1b	196	12	mechanisms	mechanism	NNS
cord-252230-s1qd3x1b	196	13	.	.	.
cord-252230-s1qd3x1b	197	1	The	the	DT
cord-252230-s1qd3x1b	197	2	mitochondrial	mitochondrial	JJ
cord-252230-s1qd3x1b	197	3	protein	protein	NN
cord-252230-s1qd3x1b	197	4	TUFM	TUFM	NNP
cord-252230-s1qd3x1b	197	5	recruits	recruit	VBZ
cord-252230-s1qd3x1b	197	6	the	the	DT
cord-252230-s1qd3x1b	197	7	ATG16L1-ATG5-ATG12	ATG16L1-ATG5-ATG12	NNS
cord-252230-s1qd3x1b	197	8	complex	complex	NN
cord-252230-s1qd3x1b	197	9	to	to	TO
cord-252230-s1qd3x1b	197	10	mediate	mediate	VB
cord-252230-s1qd3x1b	197	11	the	the	DT
cord-252230-s1qd3x1b	197	12	autophagic	autophagic	JJ
cord-252230-s1qd3x1b	197	13	removal	removal	NN
cord-252230-s1qd3x1b	197	14	of	of	IN
cord-252230-s1qd3x1b	197	15	mitochondria	mitochondrion	NNS
cord-252230-s1qd3x1b	197	16	that	that	WDT
cord-252230-s1qd3x1b	197	17	produce	produce	VBP
cord-252230-s1qd3x1b	197	18	ROS	ROS	NNP
cord-252230-s1qd3x1b	197	19	,	,	,
cord-252230-s1qd3x1b	197	20	an	an	DT
cord-252230-s1qd3x1b	197	21	activator	activator	NN
cord-252230-s1qd3x1b	197	22	of	of	IN
cord-252230-s1qd3x1b	197	23	RIG	rig	NN
cord-252230-s1qd3x1b	198	1	-I	-i	DT
cord-252230-s1qd3x1b	198	2	signaling	signal	VBG
cord-252230-s1qd3x1b	198	3	and	and	CC
cord-252230-s1qd3x1b	198	4	the	the	DT
cord-252230-s1qd3x1b	198	5	NLRP3	NLRP3	NNP
cord-252230-s1qd3x1b	198	6	inflammasome	inflammasome	NNP
cord-252230-s1qd3x1b	198	7	.	.	.
cord-252230-s1qd3x1b	199	1	By	by	IN
cord-252230-s1qd3x1b	199	2	targeting	target	VBG
cord-252230-s1qd3x1b	199	3	mitochondria	mitochondrion	NNS
cord-252230-s1qd3x1b	199	4	,	,	,
cord-252230-s1qd3x1b	199	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	199	6	further	further	RB
cord-252230-s1qd3x1b	199	7	inhibits	inhibit	VBZ
cord-252230-s1qd3x1b	199	8	IFN	IFN	NNP
cord-252230-s1qd3x1b	199	9	-	-	HYPH
cord-252230-s1qd3x1b	199	10	I	i	NN
cord-252230-s1qd3x1b	199	11	production	production	NN
cord-252230-s1qd3x1b	199	12	by	by	IN
cord-252230-s1qd3x1b	199	13	removing	remove	VBG
cord-252230-s1qd3x1b	199	14	the	the	DT
cord-252230-s1qd3x1b	199	15	signaling	signal	VBG
cord-252230-s1qd3x1b	199	16	intermediate	intermediate	JJ
cord-252230-s1qd3x1b	199	17	MAVS	MAVS	NNPS
cord-252230-s1qd3x1b	199	18	,	,	,
cord-252230-s1qd3x1b	199	19	which	which	WDT
cord-252230-s1qd3x1b	199	20	aggregates	aggregate	VBZ
cord-252230-s1qd3x1b	199	21	on	on	IN
cord-252230-s1qd3x1b	199	22	mitochondrial	mitochondrial	JJ
cord-252230-s1qd3x1b	199	23	surfaces	surface	NNS
cord-252230-s1qd3x1b	199	24	downstream	downstream	RB
cord-252230-s1qd3x1b	199	25	of	of	IN
cord-252230-s1qd3x1b	199	26	viral	viral	JJ
cord-252230-s1qd3x1b	199	27	RNA	RNA	NNP
cord-252230-s1qd3x1b	199	28	recognition	recognition	NN
cord-252230-s1qd3x1b	199	29	by	by	IN
cord-252230-s1qd3x1b	200	1	RIG	rig	NN
cord-252230-s1qd3x1b	200	2	-	-	HYPH
cord-252230-s1qd3x1b	200	3	I.	i.	NN
cord-252230-s1qd3x1b	200	4	Also	also	RB
cord-252230-s1qd3x1b	200	5	,	,	,
cord-252230-s1qd3x1b	200	6	the	the	DT
cord-252230-s1qd3x1b	200	7	ATG5-ATG12	ATG5-ATG12	NNP
cord-252230-s1qd3x1b	200	8	complex	complex	NN
cord-252230-s1qd3x1b	200	9	inhibits	inhibit	VBZ
cord-252230-s1qd3x1b	200	10	RIG	rig	NN
cord-252230-s1qd3x1b	200	11	-	-	:
cord-252230-s1qd3x1b	200	12	I	-PRON-	PRP
cord-252230-s1qd3x1b	200	13	and	and	CC
cord-252230-s1qd3x1b	200	14	MAVS	MAVS	NNPS
cord-252230-s1qd3x1b	200	15	through	through	IN
cord-252230-s1qd3x1b	200	16	an	an	DT
cord-252230-s1qd3x1b	200	17	inhibitory	inhibitory	JJ
cord-252230-s1qd3x1b	200	18	binding	binding	NN
cord-252230-s1qd3x1b	200	19	event	event	NN
cord-252230-s1qd3x1b	200	20	.	.	.
cord-252230-s1qd3x1b	201	1	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	201	2	prevents	prevent	VBZ
cord-252230-s1qd3x1b	201	3	sustained	sustain	VBN
cord-252230-s1qd3x1b	201	4	signaling	signal	VBG
cord-252230-s1qd3x1b	201	5	by	by	IN
cord-252230-s1qd3x1b	201	6	inducing	induce	VBG
cord-252230-s1qd3x1b	201	7	the	the	DT
cord-252230-s1qd3x1b	201	8	autophagic	autophagic	JJ
cord-252230-s1qd3x1b	201	9	removal	removal	NN
cord-252230-s1qd3x1b	201	10	of	of	IN
cord-252230-s1qd3x1b	201	11	cytosolic	cytosolic	JJ
cord-252230-s1qd3x1b	201	12	DNA	dna	NN
cord-252230-s1qd3x1b	201	13	and	and	CC
cord-252230-s1qd3x1b	201	14	inhibiting	inhibit	VBG
cord-252230-s1qd3x1b	201	15	cGAS	cgas	NN
cord-252230-s1qd3x1b	201	16	through	through	IN
cord-252230-s1qd3x1b	201	17	direct	direct	JJ
cord-252230-s1qd3x1b	201	18	binding	binding	NN
cord-252230-s1qd3x1b	201	19	.	.	.
cord-252230-s1qd3x1b	202	1	cGAMP	cGAMP	NNP
cord-252230-s1qd3x1b	202	2	generated	generate	VBN
cord-252230-s1qd3x1b	202	3	by	by	IN
cord-252230-s1qd3x1b	202	4	cGAS	cgas	NN
cord-252230-s1qd3x1b	202	5	activates	activate	VBZ
cord-252230-s1qd3x1b	202	6	ULK1	ULK1	NNP
cord-252230-s1qd3x1b	202	7	to	to	TO
cord-252230-s1qd3x1b	202	8	inhibit	inhibit	VB
cord-252230-s1qd3x1b	202	9	STI	STI	NNP
cord-252230-s1qd3x1b	202	10	NG	NG	NNP
cord-252230-s1qd3x1b	202	11	in	in	IN
cord-252230-s1qd3x1b	202	12	a	a	DT
cord-252230-s1qd3x1b	202	13	negative	negative	JJ
cord-252230-s1qd3x1b	202	14	feedback	feedback	NN
cord-252230-s1qd3x1b	202	15	loop	loop	NN
cord-252230-s1qd3x1b	202	16	.	.	.
cord-252230-s1qd3x1b	203	1	ATG9L1	ATG9L1	NNP
cord-252230-s1qd3x1b	203	2	interferes	interfere	VBZ
cord-252230-s1qd3x1b	203	3	with	with	IN
cord-252230-s1qd3x1b	203	4	the	the	DT
cord-252230-s1qd3x1b	203	5	trafficking	trafficking	NN
cord-252230-s1qd3x1b	203	6	of	of	IN
cord-252230-s1qd3x1b	203	7	STI	STI	NNP
cord-252230-s1qd3x1b	203	8	NG	NG	NNP
cord-252230-s1qd3x1b	203	9	to	to	TO
cord-252230-s1qd3x1b	203	10	prevent	prevent	VB
cord-252230-s1qd3x1b	203	11	continuous	continuous	JJ
cord-252230-s1qd3x1b	203	12	TBK-1	TBK-1	NNP
cord-252230-s1qd3x1b	203	13	activation	activation	NN
cord-252230-s1qd3x1b	203	14	.	.	.
cord-252230-s1qd3x1b	203	15	2013	2013	CD
cord-252230-s1qd3x1b	203	16	)	)	-RRB-
cord-252230-s1qd3x1b	203	17	.	.	.
cord-252230-s1qd3x1b	204	1	Similar	similar	JJ
cord-252230-s1qd3x1b	204	2	to	to	IN
cord-252230-s1qd3x1b	204	3	RNA	RNA	NNP
cord-252230-s1qd3x1b	204	4	sensing	sensing	NN
cord-252230-s1qd3x1b	204	5	by	by	IN
cord-252230-s1qd3x1b	204	6	RIG	rig	NN
cord-252230-s1qd3x1b	204	7	-	-	:
cord-252230-s1qd3x1b	204	8	I	I	NNP
cord-252230-s1qd3x1b	204	9	,	,	,
cord-252230-s1qd3x1b	204	10	STI	STI	NNP
cord-252230-s1qd3x1b	204	11	NG	NG	NNP
cord-252230-s1qd3x1b	204	12	(	(	-LRB-
cord-252230-s1qd3x1b	204	13	Stimulator	Stimulator	NNP
cord-252230-s1qd3x1b	204	14	of	of	IN
cord-252230-s1qd3x1b	204	15	interferon	interferon	NN
cord-252230-s1qd3x1b	204	16	genes	gene	NNS
cord-252230-s1qd3x1b	204	17	)	)	-RRB-
cord-252230-s1qd3x1b	204	18	mediates	mediate	VBZ
cord-252230-s1qd3x1b	204	19	a	a	DT
cord-252230-s1qd3x1b	204	20	TBK-1	TBK-1	NNP
cord-252230-s1qd3x1b	204	21	dependent	dependent	JJ
cord-252230-s1qd3x1b	204	22	signaling	signal	VBG
cord-252230-s1qd3x1b	204	23	cascade	cascade	NN
cord-252230-s1qd3x1b	204	24	in	in	IN
cord-252230-s1qd3x1b	204	25	the	the	DT
cord-252230-s1qd3x1b	204	26	presence	presence	NN
cord-252230-s1qd3x1b	204	27	of	of	IN
cord-252230-s1qd3x1b	204	28	cGAMP	cGAMP	NNP
cord-252230-s1qd3x1b	205	1	(	(	-LRB-
cord-252230-s1qd3x1b	205	2	Chen	Chen	NNP
cord-252230-s1qd3x1b	205	3	et	et	NNP
cord-252230-s1qd3x1b	205	4	al	al	NNP
cord-252230-s1qd3x1b	205	5	.	.	NNP
cord-252230-s1qd3x1b	205	6	,	,	,
cord-252230-s1qd3x1b	205	7	2016	2016	CD
cord-252230-s1qd3x1b	205	8	)	)	-RRB-
cord-252230-s1qd3x1b	205	9	.	.	.
cord-252230-s1qd3x1b	206	1	Deletion	deletion	NN
cord-252230-s1qd3x1b	206	2	of	of	IN
cord-252230-s1qd3x1b	206	3	ATG9L1	ATG9L1	NNP
cord-252230-s1qd3x1b	206	4	,	,	,
cord-252230-s1qd3x1b	206	5	but	but	CC
cord-252230-s1qd3x1b	206	6	not	not	RB
cord-252230-s1qd3x1b	206	7	other	other	JJ
cord-252230-s1qd3x1b	206	8	ATGs	atg	NNS
cord-252230-s1qd3x1b	206	9	,	,	,
cord-252230-s1qd3x1b	206	10	increases	increase	VBZ
cord-252230-s1qd3x1b	206	11	the	the	DT
cord-252230-s1qd3x1b	206	12	colocalization	colocalization	NN
cord-252230-s1qd3x1b	206	13	between	between	IN
cord-252230-s1qd3x1b	206	14	STI	STI	NNP
cord-252230-s1qd3x1b	206	15	NG	NG	NNP
cord-252230-s1qd3x1b	206	16	and	and	CC
cord-252230-s1qd3x1b	206	17	TBK-1	TBK-1	NNP
cord-252230-s1qd3x1b	206	18	to	to	TO
cord-252230-s1qd3x1b	206	19	enhance	enhance	VB
cord-252230-s1qd3x1b	206	20	IFN	IFN	NNP
cord-252230-s1qd3x1b	206	21	-	-	HYPH
cord-252230-s1qd3x1b	206	22	I	-PRON-	PRP
cord-252230-s1qd3x1b	206	23	production	production	NN
cord-252230-s1qd3x1b	206	24	in	in	IN
cord-252230-s1qd3x1b	206	25	response	response	NN
cord-252230-s1qd3x1b	206	26	to	to	IN
cord-252230-s1qd3x1b	206	27	cytosolic	cytosolic	JJ
cord-252230-s1qd3x1b	206	28	DNA	dna	NN
cord-252230-s1qd3x1b	206	29	(	(	-LRB-
cord-252230-s1qd3x1b	206	30	Fig	fig	NN
cord-252230-s1qd3x1b	206	31	.	.	.
cord-252230-s1qd3x1b	206	32	3	3	CD
cord-252230-s1qd3x1b	206	33	;	;	:
cord-252230-s1qd3x1b	206	34	Saitoh	Saitoh	NNP
cord-252230-s1qd3x1b	206	35	et	et	FW
cord-252230-s1qd3x1b	206	36	al	al	NNP
cord-252230-s1qd3x1b	206	37	.	.	NNP
cord-252230-s1qd3x1b	206	38	,	,	,
cord-252230-s1qd3x1b	206	39	2009	2009	CD
cord-252230-s1qd3x1b	206	40	)	)	-RRB-
cord-252230-s1qd3x1b	206	41	.	.	.
cord-252230-s1qd3x1b	207	1	Also	also	RB
cord-252230-s1qd3x1b	207	2	,	,	,
cord-252230-s1qd3x1b	207	3	generation	generation	NN
cord-252230-s1qd3x1b	207	4	of	of	IN
cord-252230-s1qd3x1b	207	5	cGAMP	cGAMP	NNS
cord-252230-s1qd3x1b	207	6	by	by	IN
cord-252230-s1qd3x1b	207	7	cGAS	cGAS	NNP
cord-252230-s1qd3x1b	207	8	activates	activate	VBZ
cord-252230-s1qd3x1b	207	9	ULK1	ULK1	NNP
cord-252230-s1qd3x1b	207	10	,	,	,
cord-252230-s1qd3x1b	207	11	which	which	WDT
cord-252230-s1qd3x1b	207	12	phosphorylates	phosphorylate	VBZ
cord-252230-s1qd3x1b	207	13	and	and	CC
cord-252230-s1qd3x1b	207	14	inhibits	inhibit	VBZ
cord-252230-s1qd3x1b	207	15	STI	STI	NNP
cord-252230-s1qd3x1b	207	16	NG	NG	NNP
cord-252230-s1qd3x1b	207	17	while	while	IN
cord-252230-s1qd3x1b	207	18	also	also	RB
cord-252230-s1qd3x1b	207	19	inducing	induce	VBG
cord-252230-s1qd3x1b	207	20	autophagy	autophagy	NN
cord-252230-s1qd3x1b	207	21	(	(	-LRB-
cord-252230-s1qd3x1b	207	22	Fig	fig	NN
cord-252230-s1qd3x1b	207	23	.	.	.
cord-252230-s1qd3x1b	208	1	3	3	LS
cord-252230-s1qd3x1b	208	2	;	;	:
cord-252230-s1qd3x1b	208	3	Konno	Konno	NNP
cord-252230-s1qd3x1b	208	4	et	et	NNP
cord-252230-s1qd3x1b	208	5	al	al	NNP
cord-252230-s1qd3x1b	208	6	.	.	NNP
cord-252230-s1qd3x1b	208	7	,	,	,
cord-252230-s1qd3x1b	208	8	2013	2013	CD
cord-252230-s1qd3x1b	208	9	)	)	-RRB-
cord-252230-s1qd3x1b	208	10	.	.	.
cord-252230-s1qd3x1b	209	1	Similarly	similarly	RB
cord-252230-s1qd3x1b	209	2	,	,	,
cord-252230-s1qd3x1b	209	3	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	209	4	can	can	MD
cord-252230-s1qd3x1b	209	5	bind	bind	VB
cord-252230-s1qd3x1b	209	6	and	and	CC
cord-252230-s1qd3x1b	209	7	inhibit	inhibit	VB
cord-252230-s1qd3x1b	209	8	cGAS	cgas	NN
cord-252230-s1qd3x1b	209	9	and	and	CC
cord-252230-s1qd3x1b	209	10	simultaneously	simultaneously	RB
cord-252230-s1qd3x1b	209	11	mediate	mediate	VB
cord-252230-s1qd3x1b	209	12	the	the	DT
cord-252230-s1qd3x1b	209	13	degradation	degradation	NN
cord-252230-s1qd3x1b	209	14	of	of	IN
cord-252230-s1qd3x1b	209	15	cytoplasmic	cytoplasmic	JJ
cord-252230-s1qd3x1b	209	16	DNA	dna	NN
cord-252230-s1qd3x1b	209	17	through	through	IN
cord-252230-s1qd3x1b	209	18	autophagy	autophagy	NN
cord-252230-s1qd3x1b	209	19	(	(	-LRB-
cord-252230-s1qd3x1b	209	20	Fig	fig	NN
cord-252230-s1qd3x1b	209	21	.	.	.
cord-252230-s1qd3x1b	209	22	3	3	CD
cord-252230-s1qd3x1b	209	23	;	;	:
cord-252230-s1qd3x1b	209	24	Liang	Liang	NNP
cord-252230-s1qd3x1b	209	25	et	et	NNP
cord-252230-s1qd3x1b	209	26	al	al	NNP
cord-252230-s1qd3x1b	209	27	.	.	.
cord-252230-s1qd3x1b	210	1	,	,	,
cord-252230-s1qd3x1b	210	2	2014	2014	CD
cord-252230-s1qd3x1b	210	3	)	)	-RRB-
cord-252230-s1qd3x1b	210	4	.	.	.
cord-252230-s1qd3x1b	211	1	Thus	thus	RB
cord-252230-s1qd3x1b	211	2	,	,	,
cord-252230-s1qd3x1b	211	3	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	211	4	prevents	prevent	VBZ
cord-252230-s1qd3x1b	211	5	sustained	sustained	JJ
cord-252230-s1qd3x1b	211	6	cGAS	cgas	NN
cord-252230-s1qd3x1b	211	7	activation	activation	NN
cord-252230-s1qd3x1b	211	8	through	through	IN
cord-252230-s1qd3x1b	211	9	both	both	CC
cord-252230-s1qd3x1b	211	10	direct	direct	JJ
cord-252230-s1qd3x1b	211	11	inhibition	inhibition	NN
cord-252230-s1qd3x1b	211	12	and	and	CC
cord-252230-s1qd3x1b	211	13	depriving	deprive	VBG
cord-252230-s1qd3x1b	211	14	the	the	DT
cord-252230-s1qd3x1b	211	15	enzyme	enzyme	NN
cord-252230-s1qd3x1b	211	16	of	of	IN
cord-252230-s1qd3x1b	211	17	its	-PRON-	PRP$
cord-252230-s1qd3x1b	211	18	substrate	substrate	NN
cord-252230-s1qd3x1b	211	19	.	.	.
cord-252230-s1qd3x1b	212	1	In	in	IN
cord-252230-s1qd3x1b	212	2	these	these	DT
cord-252230-s1qd3x1b	212	3	examples	example	NNS
cord-252230-s1qd3x1b	212	4	,	,	,
cord-252230-s1qd3x1b	212	5	conserved	conserve	VBN
cord-252230-s1qd3x1b	212	6	autophagy	autophagy	NN
cord-252230-s1qd3x1b	212	7	proteins	protein	NNS
cord-252230-s1qd3x1b	212	8	(	(	-LRB-
cord-252230-s1qd3x1b	212	9	ATG9L1	ATG9L1	NNP
cord-252230-s1qd3x1b	212	10	,	,	,
cord-252230-s1qd3x1b	212	11	ULK1	ULK1	NNP
cord-252230-s1qd3x1b	212	12	,	,	,
cord-252230-s1qd3x1b	212	13	and	and	CC
cord-252230-s1qd3x1b	212	14	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	212	15	)	)	-RRB-
cord-252230-s1qd3x1b	212	16	display	display	NN
cord-252230-s1qd3x1b	212	17	functions	function	NNS
cord-252230-s1qd3x1b	212	18	independent	independent	JJ
cord-252230-s1qd3x1b	212	19	of	of	IN
cord-252230-s1qd3x1b	212	20	autophagy	autophagy	NN
cord-252230-s1qd3x1b	212	21	-	-	HYPH
cord-252230-s1qd3x1b	212	22	related	relate	VBN
cord-252230-s1qd3x1b	212	23	processes	process	NNS
cord-252230-s1qd3x1b	212	24	,	,	,
cord-252230-s1qd3x1b	212	25	although	although	IN
cord-252230-s1qd3x1b	212	26	these	these	DT
cord-252230-s1qd3x1b	212	27	functions	function	NNS
cord-252230-s1qd3x1b	212	28	do	do	VBP
cord-252230-s1qd3x1b	212	29	not	not	RB
cord-252230-s1qd3x1b	212	30	necessarily	necessarily	RB
cord-252230-s1qd3x1b	212	31	preclude	preclude	VB
cord-252230-s1qd3x1b	212	32	their	-PRON-	PRP$
cord-252230-s1qd3x1b	212	33	role	role	NN
cord-252230-s1qd3x1b	212	34	in	in	IN
cord-252230-s1qd3x1b	212	35	classic	classic	JJ
cord-252230-s1qd3x1b	212	36	autophagy	autophagy	NN
cord-252230-s1qd3x1b	212	37	.	.	.
cord-252230-s1qd3x1b	213	1	ATGs	ATGs	NNPS
cord-252230-s1qd3x1b	213	2	and	and	CC
cord-252230-s1qd3x1b	213	3	inflammasome	inflammasome	NNP
cord-252230-s1qd3x1b	213	4	activation	activation	NN
cord-252230-s1qd3x1b	213	5	.	.	.
cord-252230-s1qd3x1b	214	1	Inflammasomes	Inflammasomes	NNP
cord-252230-s1qd3x1b	214	2	are	be	VBP
cord-252230-s1qd3x1b	214	3	multiprotein	multiprotein	NNP
cord-252230-s1qd3x1b	214	4	complexes	complex	NNS
cord-252230-s1qd3x1b	214	5	that	that	WDT
cord-252230-s1qd3x1b	214	6	induce	induce	VBP
cord-252230-s1qd3x1b	214	7	the	the	DT
cord-252230-s1qd3x1b	214	8	cleavage	cleavage	NN
cord-252230-s1qd3x1b	214	9	of	of	IN
cord-252230-s1qd3x1b	214	10	pro	pro	JJ
cord-252230-s1qd3x1b	214	11	-	-	JJ
cord-252230-s1qd3x1b	214	12	IL-1β	il-1β	JJ
cord-252230-s1qd3x1b	214	13	and	and	CC
cord-252230-s1qd3x1b	214	14	pro	pro	JJ
cord-252230-s1qd3x1b	214	15	-	-	NN
cord-252230-s1qd3x1b	214	16	IL-18	IL-18	NNP
cord-252230-s1qd3x1b	214	17	by	by	IN
cord-252230-s1qd3x1b	214	18	caspase-1	caspase-1	NNP
cord-252230-s1qd3x1b	214	19	to	to	TO
cord-252230-s1qd3x1b	214	20	generate	generate	VB
cord-252230-s1qd3x1b	214	21	the	the	DT
cord-252230-s1qd3x1b	214	22	activate	activate	JJ
cord-252230-s1qd3x1b	214	23	forms	form	NNS
cord-252230-s1qd3x1b	214	24	of	of	IN
cord-252230-s1qd3x1b	214	25	these	these	DT
cord-252230-s1qd3x1b	214	26	cytokines	cytokine	NNS
cord-252230-s1qd3x1b	214	27	(	(	-LRB-
cord-252230-s1qd3x1b	214	28	Sharma	Sharma	NNP
cord-252230-s1qd3x1b	214	29	and	and	CC
cord-252230-s1qd3x1b	214	30	Kanneganti	Kanneganti	NNP
cord-252230-s1qd3x1b	214	31	,	,	,
cord-252230-s1qd3x1b	214	32	2016	2016	CD
cord-252230-s1qd3x1b	214	33	)	)	-RRB-
cord-252230-s1qd3x1b	214	34	.	.	.
cord-252230-s1qd3x1b	215	1	The	the	DT
cord-252230-s1qd3x1b	215	2	NLRP3	nlrp3	NN
cord-252230-s1qd3x1b	215	3	inflammasome	inflammasome	NN
cord-252230-s1qd3x1b	215	4	responds	respond	VBZ
cord-252230-s1qd3x1b	215	5	to	to	IN
cord-252230-s1qd3x1b	215	6	a	a	DT
cord-252230-s1qd3x1b	215	7	variety	variety	NN
cord-252230-s1qd3x1b	215	8	of	of	IN
cord-252230-s1qd3x1b	215	9	stimuli	stimulus	NNS
cord-252230-s1qd3x1b	215	10	that	that	WDT
cord-252230-s1qd3x1b	215	11	directly	directly	RB
cord-252230-s1qd3x1b	215	12	or	or	CC
cord-252230-s1qd3x1b	215	13	indirectly	indirectly	RB
cord-252230-s1qd3x1b	215	14	cause	cause	VB
cord-252230-s1qd3x1b	215	15	the	the	DT
cord-252230-s1qd3x1b	215	16	release	release	NN
cord-252230-s1qd3x1b	215	17	of	of	IN
cord-252230-s1qd3x1b	215	18	ROS	ROS	NNP
cord-252230-s1qd3x1b	215	19	and	and	CC
cord-252230-s1qd3x1b	215	20	DNA	dna	NN
cord-252230-s1qd3x1b	215	21	from	from	IN
cord-252230-s1qd3x1b	215	22	leaky	leaky	JJ
cord-252230-s1qd3x1b	215	23	mitochondria	mitochondrion	NNS
cord-252230-s1qd3x1b	215	24	(	(	-LRB-
cord-252230-s1qd3x1b	215	25	e.g.	e.g.	RB
cord-252230-s1qd3x1b	215	26	,	,	,
cord-252230-s1qd3x1b	215	27	bacterial	bacterial	JJ
cord-252230-s1qd3x1b	215	28	toxins	toxin	NNS
cord-252230-s1qd3x1b	215	29	and	and	CC
cord-252230-s1qd3x1b	215	30	microcrystalline	microcrystalline	JJ
cord-252230-s1qd3x1b	215	31	substances	substance	NNS
cord-252230-s1qd3x1b	215	32	)	)	-RRB-
cord-252230-s1qd3x1b	215	33	.	.	.
cord-252230-s1qd3x1b	216	1	Inhibiting	inhibit	VBG
cord-252230-s1qd3x1b	216	2	mitophagy	mitophagy	NNS
cord-252230-s1qd3x1b	216	3	,	,	,
cord-252230-s1qd3x1b	216	4	therefore	therefore	RB
cord-252230-s1qd3x1b	216	5	,	,	,
cord-252230-s1qd3x1b	216	6	leads	lead	VBZ
cord-252230-s1qd3x1b	216	7	to	to	IN
cord-252230-s1qd3x1b	216	8	accumulation	accumulation	NN
cord-252230-s1qd3x1b	216	9	of	of	IN
cord-252230-s1qd3x1b	216	10	damaged	damaged	JJ
cord-252230-s1qd3x1b	216	11	mitochondria	mitochondrion	NNS
cord-252230-s1qd3x1b	216	12	that	that	WDT
cord-252230-s1qd3x1b	216	13	induce	induce	VBP
cord-252230-s1qd3x1b	216	14	pathological	pathological	JJ
cord-252230-s1qd3x1b	216	15	cytokine	cytokine	NN
cord-252230-s1qd3x1b	216	16	production	production	NN
cord-252230-s1qd3x1b	216	17	downstream	downstream	NN
cord-252230-s1qd3x1b	216	18	of	of	IN
cord-252230-s1qd3x1b	216	19	NLRP3	NLRP3	NNP
cord-252230-s1qd3x1b	216	20	inflammasome	inflammasome	NNP
cord-252230-s1qd3x1b	216	21	activation	activation	NN
cord-252230-s1qd3x1b	216	22	(	(	-LRB-
cord-252230-s1qd3x1b	216	23	Fig	Fig	NNP
cord-252230-s1qd3x1b	216	24	.	.	.
cord-252230-s1qd3x1b	216	25	3	3	CD
cord-252230-s1qd3x1b	216	26	;	;	.
cord-252230-s1qd3x1b	217	1	Saitoh	Saitoh	NNP
cord-252230-s1qd3x1b	217	2	et	et	FW
cord-252230-s1qd3x1b	217	3	al	al	NNP
cord-252230-s1qd3x1b	217	4	.	.	NNP
cord-252230-s1qd3x1b	217	5	,	,	,
cord-252230-s1qd3x1b	217	6	2008	2008	CD
cord-252230-s1qd3x1b	218	1	;	;	:
cord-252230-s1qd3x1b	218	2	Zhong	Zhong	NNP
cord-252230-s1qd3x1b	218	3	et	et	NNP
cord-252230-s1qd3x1b	218	4	al	al	NNP
cord-252230-s1qd3x1b	218	5	.	.	NNP
cord-252230-s1qd3x1b	218	6	,	,	,
cord-252230-s1qd3x1b	218	7	2016	2016	CD
cord-252230-s1qd3x1b	218	8	)	)	-RRB-
cord-252230-s1qd3x1b	218	9	.	.	.
cord-252230-s1qd3x1b	219	1	ATGs	atg	NNS
cord-252230-s1qd3x1b	219	2	also	also	RB
cord-252230-s1qd3x1b	219	3	inhibit	inhibit	VBP
cord-252230-s1qd3x1b	219	4	the	the	DT
cord-252230-s1qd3x1b	219	5	caspase-11	caspase-11	NNP
cord-252230-s1qd3x1b	219	6	inflammasome	inflammasome	NNP
cord-252230-s1qd3x1b	219	7	,	,	,
cord-252230-s1qd3x1b	219	8	which	which	WDT
cord-252230-s1qd3x1b	219	9	is	be	VBZ
cord-252230-s1qd3x1b	219	10	activated	activate	VBN
cord-252230-s1qd3x1b	219	11	by	by	IN
cord-252230-s1qd3x1b	219	12	the	the	DT
cord-252230-s1qd3x1b	219	13	bacterial	bacterial	JJ
cord-252230-s1qd3x1b	219	14	cell	cell	NN
cord-252230-s1qd3x1b	219	15	wall	wall	NN
cord-252230-s1qd3x1b	219	16	component	component	NN
cord-252230-s1qd3x1b	219	17	lipopolysaccharide	lipopolysaccharide	NN
cord-252230-s1qd3x1b	219	18	in	in	IN
cord-252230-s1qd3x1b	219	19	the	the	DT
cord-252230-s1qd3x1b	219	20	cytosol	cytosol	NN
cord-252230-s1qd3x1b	219	21	.	.	.
cord-252230-s1qd3x1b	220	1	When	when	WRB
cord-252230-s1qd3x1b	220	2	IFN	IFN	NNP
cord-252230-s1qd3x1b	220	3	-	-	HYPH
cord-252230-s1qd3x1b	220	4	inducible	inducible	JJ
cord-252230-s1qd3x1b	220	5	GTPases	gtpase	NNS
cord-252230-s1qd3x1b	220	6	attack	attack	NN
cord-252230-s1qd3x1b	220	7	the	the	DT
cord-252230-s1qd3x1b	220	8	Salmonellacontaining	Salmonellacontaining	NNP
cord-252230-s1qd3x1b	220	9	vacuole	vacuole	NN
cord-252230-s1qd3x1b	220	10	as	as	IN
cord-252230-s1qd3x1b	220	11	part	part	NN
cord-252230-s1qd3x1b	220	12	of	of	IN
cord-252230-s1qd3x1b	220	13	the	the	DT
cord-252230-s1qd3x1b	220	14	host	host	NN
cord-252230-s1qd3x1b	220	15	defense	defense	NN
cord-252230-s1qd3x1b	220	16	mechanism	mechanism	NN
cord-252230-s1qd3x1b	220	17	,	,	,
cord-252230-s1qd3x1b	220	18	LC3	LC3	NNP
cord-252230-s1qd3x1b	220	19	is	be	VBZ
cord-252230-s1qd3x1b	220	20	recruited	recruit	VBN
cord-252230-s1qd3x1b	220	21	to	to	IN
cord-252230-s1qd3x1b	220	22	the	the	DT
cord-252230-s1qd3x1b	220	23	damaged	damage	VBN
cord-252230-s1qd3x1b	220	24	membrane	membrane	NN
cord-252230-s1qd3x1b	220	25	by	by	IN
cord-252230-s1qd3x1b	220	26	the	the	DT
cord-252230-s1qd3x1b	220	27	linker	linker	NN
cord-252230-s1qd3x1b	220	28	protein	protein	NN
cord-252230-s1qd3x1b	220	29	NDP52	NDP52	NNP
cord-252230-s1qd3x1b	220	30	to	to	TO
cord-252230-s1qd3x1b	220	31	mediate	mediate	VB
cord-252230-s1qd3x1b	220	32	the	the	DT
cord-252230-s1qd3x1b	220	33	autophagic	autophagic	NN
cord-252230-s1qd3x1b	220	34	sequestration	sequestration	NN
cord-252230-s1qd3x1b	220	35	of	of	IN
cord-252230-s1qd3x1b	220	36	bacteria	bacteria	NNS
cord-252230-s1qd3x1b	220	37	and	and	CC
cord-252230-s1qd3x1b	220	38	lipopolysaccharide	lipopolysaccharide	NN
cord-252230-s1qd3x1b	220	39	,	,	,
cord-252230-s1qd3x1b	220	40	which	which	WDT
cord-252230-s1qd3x1b	220	41	inhibits	inhibit	VBZ
cord-252230-s1qd3x1b	220	42	inflammasome	inflammasome	NNP
cord-252230-s1qd3x1b	220	43	activation	activation	NN
cord-252230-s1qd3x1b	220	44	(	(	-LRB-
cord-252230-s1qd3x1b	220	45	Meunier	Meunier	NNP
cord-252230-s1qd3x1b	220	46	et	et	NNP
cord-252230-s1qd3x1b	220	47	al	al	NNP
cord-252230-s1qd3x1b	220	48	.	.	NNP
cord-252230-s1qd3x1b	220	49	,	,	,
cord-252230-s1qd3x1b	220	50	2014	2014	CD
cord-252230-s1qd3x1b	220	51	)	)	-RRB-
cord-252230-s1qd3x1b	220	52	.	.	.
cord-252230-s1qd3x1b	221	1	Hence	hence	RB
cord-252230-s1qd3x1b	221	2	,	,	,
cord-252230-s1qd3x1b	221	3	it	-PRON-	PRP
cord-252230-s1qd3x1b	221	4	is	be	VBZ
cord-252230-s1qd3x1b	221	5	likely	likely	JJ
cord-252230-s1qd3x1b	221	6	that	that	DT
cord-252230-s1qd3x1b	221	7	removal	removal	NN
cord-252230-s1qd3x1b	221	8	of	of	IN
cord-252230-s1qd3x1b	221	9	damaged	damage	VBN
cord-252230-s1qd3x1b	221	10	vesicles	vesicle	NNS
cord-252230-s1qd3x1b	221	11	and	and	CC
cord-252230-s1qd3x1b	221	12	organelles	organelle	NNS
cord-252230-s1qd3x1b	221	13	(	(	-LRB-
cord-252230-s1qd3x1b	221	14	or	or	CC
cord-252230-s1qd3x1b	221	15	their	-PRON-	PRP$
cord-252230-s1qd3x1b	221	16	contents	content	NNS
cord-252230-s1qd3x1b	221	17	)	)	-RRB-
cord-252230-s1qd3x1b	221	18	through	through	IN
cord-252230-s1qd3x1b	221	19	classic	classic	JJ
cord-252230-s1qd3x1b	221	20	autophagy	autophagy	NN
cord-252230-s1qd3x1b	221	21	restrains	restrain	VBZ
cord-252230-s1qd3x1b	221	22	inflammasome	inflammasome	NN
cord-252230-s1qd3x1b	221	23	activity	activity	NN
cord-252230-s1qd3x1b	221	24	,	,	,
cord-252230-s1qd3x1b	221	25	thereby	thereby	RB
cord-252230-s1qd3x1b	221	26	explaining	explain	VBG
cord-252230-s1qd3x1b	221	27	why	why	WRB
cord-252230-s1qd3x1b	221	28	inhibiting	inhibit	VBG
cord-252230-s1qd3x1b	221	29	autophagy	autophagy	NN
cord-252230-s1qd3x1b	221	30	proteins	protein	NNS
cord-252230-s1qd3x1b	221	31	such	such	JJ
cord-252230-s1qd3x1b	221	32	as	as	IN
cord-252230-s1qd3x1b	221	33	ATG16L1	ATG16L1	NNS
cord-252230-s1qd3x1b	221	34	enhance	enhance	VBP
cord-252230-s1qd3x1b	221	35	IL-1β	il-1β	NN
cord-252230-s1qd3x1b	221	36	and	and	CC
cord-252230-s1qd3x1b	221	37	IL-18	IL-18	NNP
cord-252230-s1qd3x1b	221	38	production	production	NN
cord-252230-s1qd3x1b	221	39	.	.	.
cord-252230-s1qd3x1b	222	1	Here	here	RB
cord-252230-s1qd3x1b	222	2	,	,	,
cord-252230-s1qd3x1b	222	3	we	-PRON-	PRP
cord-252230-s1qd3x1b	222	4	use	use	VBP
cord-252230-s1qd3x1b	222	5	IBD	IBD	NNP
cord-252230-s1qd3x1b	222	6	,	,	,
cord-252230-s1qd3x1b	222	7	rheumatoid	rheumatoid	NN
cord-252230-s1qd3x1b	222	8	arthritis	arthritis	NN
cord-252230-s1qd3x1b	222	9	(	(	-LRB-
cord-252230-s1qd3x1b	222	10	RA	RA	NNP
cord-252230-s1qd3x1b	222	11	)	)	-RRB-
cord-252230-s1qd3x1b	222	12	,	,	,
cord-252230-s1qd3x1b	222	13	and	and	CC
cord-252230-s1qd3x1b	222	14	systemic	systemic	JJ
cord-252230-s1qd3x1b	222	15	lupus	lupus	NN
cord-252230-s1qd3x1b	222	16	erythematosus	erythematosus	NN
cord-252230-s1qd3x1b	222	17	(	(	-LRB-
cord-252230-s1qd3x1b	222	18	SLE	SLE	NNP
cord-252230-s1qd3x1b	222	19	)	)	-RRB-
cord-252230-s1qd3x1b	222	20	as	as	IN
cord-252230-s1qd3x1b	222	21	examples	example	NNS
cord-252230-s1qd3x1b	222	22	of	of	IN
cord-252230-s1qd3x1b	222	23	how	how	WRB
cord-252230-s1qd3x1b	222	24	ATGs	atg	NNS
cord-252230-s1qd3x1b	222	25	contribute	contribute	VBP
cord-252230-s1qd3x1b	222	26	to	to	IN
cord-252230-s1qd3x1b	222	27	complex	complex	JJ
cord-252230-s1qd3x1b	222	28	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	222	29	diseases	disease	NNS
cord-252230-s1qd3x1b	222	30	.	.	.
cord-252230-s1qd3x1b	223	1	IBD	IBD	NNP
cord-252230-s1qd3x1b	223	2	includes	include	VBZ
cord-252230-s1qd3x1b	223	3	Crohn	Crohn	NNP
cord-252230-s1qd3x1b	223	4	's	's	POS
cord-252230-s1qd3x1b	223	5	disease	disease	NN
cord-252230-s1qd3x1b	223	6	and	and	CC
cord-252230-s1qd3x1b	223	7	ulcerative	ulcerative	JJ
cord-252230-s1qd3x1b	223	8	colitis	colitis	NN
cord-252230-s1qd3x1b	223	9	,	,	,
cord-252230-s1qd3x1b	223	10	and	and	CC
cord-252230-s1qd3x1b	223	11	is	be	VBZ
cord-252230-s1qd3x1b	223	12	frequently	frequently	RB
cord-252230-s1qd3x1b	223	13	a	a	DT
cord-252230-s1qd3x1b	223	14	debilitating	debilitating	JJ
cord-252230-s1qd3x1b	223	15	condition	condition	NN
cord-252230-s1qd3x1b	223	16	that	that	WDT
cord-252230-s1qd3x1b	223	17	involves	involve	VBZ
cord-252230-s1qd3x1b	223	18	chronic	chronic	JJ
cord-252230-s1qd3x1b	223	19	inflammation	inflammation	NN
cord-252230-s1qd3x1b	223	20	in	in	IN
cord-252230-s1qd3x1b	223	21	the	the	DT
cord-252230-s1qd3x1b	223	22	small	small	JJ
cord-252230-s1qd3x1b	223	23	intestine	intestine	NN
cord-252230-s1qd3x1b	223	24	or	or	CC
cord-252230-s1qd3x1b	223	25	colon	colon	NN
cord-252230-s1qd3x1b	223	26	,	,	,
cord-252230-s1qd3x1b	223	27	although	although	IN
cord-252230-s1qd3x1b	223	28	any	any	DT
cord-252230-s1qd3x1b	223	29	part	part	NN
cord-252230-s1qd3x1b	223	30	of	of	IN
cord-252230-s1qd3x1b	223	31	the	the	DT
cord-252230-s1qd3x1b	223	32	gastrointestinal	gastrointestinal	JJ
cord-252230-s1qd3x1b	223	33	tract	tract	NN
cord-252230-s1qd3x1b	223	34	can	can	MD
cord-252230-s1qd3x1b	223	35	be	be	VB
cord-252230-s1qd3x1b	223	36	affected	affect	VBN
cord-252230-s1qd3x1b	223	37	.	.	.
cord-252230-s1qd3x1b	224	1	Many	many	JJ
cord-252230-s1qd3x1b	224	2	genetic	genetic	JJ
cord-252230-s1qd3x1b	224	3	variants	variant	NNS
cord-252230-s1qd3x1b	224	4	that	that	WDT
cord-252230-s1qd3x1b	224	5	increase	increase	VBP
cord-252230-s1qd3x1b	224	6	risk	risk	NN
cord-252230-s1qd3x1b	224	7	of	of	IN
cord-252230-s1qd3x1b	224	8	IBD	IBD	NNP
cord-252230-s1qd3x1b	224	9	,	,	,
cord-252230-s1qd3x1b	224	10	including	include	VBG
cord-252230-s1qd3x1b	224	11	several	several	JJ
cord-252230-s1qd3x1b	224	12	known	know	VBN
cord-252230-s1qd3x1b	224	13	to	to	TO
cord-252230-s1qd3x1b	224	14	affect	affect	VB
cord-252230-s1qd3x1b	224	15	autophagy	autophagy	NN
cord-252230-s1qd3x1b	224	16	,	,	,
cord-252230-s1qd3x1b	224	17	are	be	VBP
cord-252230-s1qd3x1b	224	18	also	also	RB
cord-252230-s1qd3x1b	224	19	found	find	VBN
cord-252230-s1qd3x1b	224	20	in	in	IN
cord-252230-s1qd3x1b	224	21	individuals	individual	NNS
cord-252230-s1qd3x1b	224	22	without	without	IN
cord-252230-s1qd3x1b	224	23	disease	disease	NN
cord-252230-s1qd3x1b	224	24	(	(	-LRB-
cord-252230-s1qd3x1b	224	25	Lassen	Lassen	NNP
cord-252230-s1qd3x1b	224	26	and	and	CC
cord-252230-s1qd3x1b	224	27	Xavier	Xavier	NNP
cord-252230-s1qd3x1b	224	28	,	,	,
cord-252230-s1qd3x1b	224	29	2017	2017	CD
cord-252230-s1qd3x1b	224	30	)	)	-RRB-
cord-252230-s1qd3x1b	224	31	.	.	.
cord-252230-s1qd3x1b	225	1	A	a	DT
cord-252230-s1qd3x1b	225	2	particularly	particularly	RB
cord-252230-s1qd3x1b	225	3	common	common	JJ
cord-252230-s1qd3x1b	225	4	polymorphism	polymorphism	NN
cord-252230-s1qd3x1b	225	5	in	in	IN
cord-252230-s1qd3x1b	225	6	ATG16L1	ATG16L1	NNP
cord-252230-s1qd3x1b	225	7	(	(	-LRB-
cord-252230-s1qd3x1b	225	8	up	up	IN
cord-252230-s1qd3x1b	225	9	to	to	TO
cord-252230-s1qd3x1b	225	10	50	50	CD
cord-252230-s1qd3x1b	225	11	%	%	NN
cord-252230-s1qd3x1b	225	12	heterozygosity	heterozygosity	NN
cord-252230-s1qd3x1b	225	13	in	in	IN
cord-252230-s1qd3x1b	225	14	certain	certain	JJ
cord-252230-s1qd3x1b	225	15	populations	population	NNS
cord-252230-s1qd3x1b	225	16	)	)	-RRB-
cord-252230-s1qd3x1b	225	17	linked	link	VBN
cord-252230-s1qd3x1b	225	18	to	to	IN
cord-252230-s1qd3x1b	225	19	Crohn	Crohn	NNP
cord-252230-s1qd3x1b	225	20	's	's	POS
cord-252230-s1qd3x1b	225	21	disease	disease	NN
cord-252230-s1qd3x1b	225	22	introduces	introduce	VBZ
cord-252230-s1qd3x1b	225	23	a	a	DT
cord-252230-s1qd3x1b	225	24	caspase-3	caspase-3	NNP
cord-252230-s1qd3x1b	225	25	cleavage	cleavage	NN
cord-252230-s1qd3x1b	225	26	site	site	NN
cord-252230-s1qd3x1b	225	27	that	that	WDT
cord-252230-s1qd3x1b	225	28	destabilizes	destabilize	VBZ
cord-252230-s1qd3x1b	225	29	the	the	DT
cord-252230-s1qd3x1b	225	30	protein	protein	NN
cord-252230-s1qd3x1b	225	31	product	product	NN
cord-252230-s1qd3x1b	225	32	(	(	-LRB-
cord-252230-s1qd3x1b	225	33	ATG16L1	ATG16L1	NNP
cord-252230-s1qd3x1b	225	34	T300A	T300A	NNP
cord-252230-s1qd3x1b	225	35	)	)	-RRB-
cord-252230-s1qd3x1b	225	36	,	,	,
cord-252230-s1qd3x1b	225	37	thereby	thereby	RB
cord-252230-s1qd3x1b	225	38	causing	cause	VBG
cord-252230-s1qd3x1b	225	39	a	a	DT
cord-252230-s1qd3x1b	225	40	reduction	reduction	NN
cord-252230-s1qd3x1b	225	41	in	in	IN
cord-252230-s1qd3x1b	225	42	autophagy	autophagy	NN
cord-252230-s1qd3x1b	225	43	(	(	-LRB-
cord-252230-s1qd3x1b	225	44	Lassen	Lassen	NNP
cord-252230-s1qd3x1b	225	45	et	et	NNP
cord-252230-s1qd3x1b	225	46	al	al	NNP
cord-252230-s1qd3x1b	225	47	.	.	NNP
cord-252230-s1qd3x1b	225	48	,	,	,
cord-252230-s1qd3x1b	225	49	2014	2014	CD
cord-252230-s1qd3x1b	225	50	;	;	.
cord-252230-s1qd3x1b	226	1	Murthy	Murthy	NNP
cord-252230-s1qd3x1b	226	2	et	et	NNP
cord-252230-s1qd3x1b	226	3	al	al	NNP
cord-252230-s1qd3x1b	226	4	.	.	.
cord-252230-s1qd3x1b	227	1	,	,	,
cord-252230-s1qd3x1b	227	2	2014	2014	CD
cord-252230-s1qd3x1b	227	3	)	)	-RRB-
cord-252230-s1qd3x1b	227	4	.	.	.
cord-252230-s1qd3x1b	228	1	ATG16L1	ATG16L1	NNP
cord-252230-s1qd3x1b	229	1	T300A	T300A	NNP
cord-252230-s1qd3x1b	229	2	is	be	VBZ
cord-252230-s1qd3x1b	229	3	associated	associate	VBN
cord-252230-s1qd3x1b	229	4	with	with	IN
cord-252230-s1qd3x1b	229	5	structural	structural	JJ
cord-252230-s1qd3x1b	229	6	defects	defect	NNS
cord-252230-s1qd3x1b	229	7	in	in	IN
cord-252230-s1qd3x1b	229	8	Paneth	Paneth	NNP
cord-252230-s1qd3x1b	229	9	cells	cell	NNS
cord-252230-s1qd3x1b	229	10	,	,	,
cord-252230-s1qd3x1b	229	11	intestinal	intestinal	JJ
cord-252230-s1qd3x1b	229	12	epithelial	epithelial	JJ
cord-252230-s1qd3x1b	229	13	cells	cell	NNS
cord-252230-s1qd3x1b	229	14	that	that	WDT
cord-252230-s1qd3x1b	229	15	produce	produce	VBP
cord-252230-s1qd3x1b	229	16	antimicrobial	antimicrobial	NN
cord-252230-s1qd3x1b	229	17	granules	granule	NNS
cord-252230-s1qd3x1b	229	18	(	(	-LRB-
cord-252230-s1qd3x1b	229	19	Cadwell	Cadwell	NNP
cord-252230-s1qd3x1b	229	20	et	et	NNP
cord-252230-s1qd3x1b	229	21	al	al	NNP
cord-252230-s1qd3x1b	229	22	.	.	NNP
cord-252230-s1qd3x1b	229	23	,	,	,
cord-252230-s1qd3x1b	229	24	2008	2008	CD
cord-252230-s1qd3x1b	229	25	)	)	-RRB-
cord-252230-s1qd3x1b	229	26	.	.	.
cord-252230-s1qd3x1b	230	1	Additional	additional	JJ
cord-252230-s1qd3x1b	230	2	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	230	3	pathologies	pathology	NNS
cord-252230-s1qd3x1b	230	4	in	in	IN
cord-252230-s1qd3x1b	230	5	the	the	DT
cord-252230-s1qd3x1b	230	6	intestinal	intestinal	JJ
cord-252230-s1qd3x1b	230	7	epithelium	epithelium	NN
cord-252230-s1qd3x1b	230	8	of	of	IN
cord-252230-s1qd3x1b	230	9	Atg16L1	Atg16L1	NNP
cord-252230-s1qd3x1b	230	10	mutant	mutant	JJ
cord-252230-s1qd3x1b	230	11	mice	mouse	NNS
cord-252230-s1qd3x1b	230	12	is	be	VBZ
cord-252230-s1qd3x1b	230	13	triggered	trigger	VBN
cord-252230-s1qd3x1b	230	14	by	by	IN
cord-252230-s1qd3x1b	230	15	a	a	DT
cord-252230-s1qd3x1b	230	16	commensal	commensal	JJ
cord-252230-s1qd3x1b	230	17	enteric	enteric	JJ
cord-252230-s1qd3x1b	230	18	virus	virus	NN
cord-252230-s1qd3x1b	230	19	(	(	-LRB-
cord-252230-s1qd3x1b	230	20	Cadwell	Cadwell	NNP
cord-252230-s1qd3x1b	230	21	et	et	NNP
cord-252230-s1qd3x1b	230	22	al	al	NNP
cord-252230-s1qd3x1b	230	23	.	.	NNP
cord-252230-s1qd3x1b	230	24	,	,	,
cord-252230-s1qd3x1b	230	25	2010	2010	CD
cord-252230-s1qd3x1b	230	26	;	;	:
cord-252230-s1qd3x1b	230	27	Kernbauer	Kernbauer	NNP
cord-252230-s1qd3x1b	230	28	et	et	NNP
cord-252230-s1qd3x1b	230	29	al	al	NNP
cord-252230-s1qd3x1b	230	30	.	.	NNP
cord-252230-s1qd3x1b	230	31	,	,	,
cord-252230-s1qd3x1b	230	32	2014	2014	CD
cord-252230-s1qd3x1b	230	33	)	)	-RRB-
cord-252230-s1qd3x1b	230	34	,	,	,
cord-252230-s1qd3x1b	230	35	or	or	CC
cord-252230-s1qd3x1b	230	36	by	by	IN
cord-252230-s1qd3x1b	230	37	dual	dual	JJ
cord-252230-s1qd3x1b	230	38	deletion	deletion	NN
cord-252230-s1qd3x1b	230	39	of	of	IN
cord-252230-s1qd3x1b	230	40	ATG16L1	ATG16L1	NNS
cord-252230-s1qd3x1b	230	41	and	and	CC
cord-252230-s1qd3x1b	230	42	the	the	DT
cord-252230-s1qd3x1b	230	43	ER	ER	NNP
cord-252230-s1qd3x1b	230	44	stress	stress	NN
cord-252230-s1qd3x1b	230	45	transcription	transcription	NN
cord-252230-s1qd3x1b	230	46	factor	factor	NN
cord-252230-s1qd3x1b	230	47	XBP-1	XBP-1	NNP
cord-252230-s1qd3x1b	230	48	in	in	IN
cord-252230-s1qd3x1b	230	49	Paneth	Paneth	NNP
cord-252230-s1qd3x1b	230	50	cells	cell	NNS
cord-252230-s1qd3x1b	230	51	(	(	-LRB-
cord-252230-s1qd3x1b	230	52	Adolph	Adolph	NNP
cord-252230-s1qd3x1b	230	53	et	et	NNP
cord-252230-s1qd3x1b	230	54	al	al	NNP
cord-252230-s1qd3x1b	230	55	.	.	NNP
cord-252230-s1qd3x1b	230	56	,	,	,
cord-252230-s1qd3x1b	230	57	2013	2013	CD
cord-252230-s1qd3x1b	230	58	)	)	-RRB-
cord-252230-s1qd3x1b	230	59	.	.	.
cord-252230-s1qd3x1b	231	1	These	these	DT
cord-252230-s1qd3x1b	231	2	findings	finding	NNS
cord-252230-s1qd3x1b	231	3	are	be	VBP
cord-252230-s1qd3x1b	231	4	consistent	consistent	JJ
cord-252230-s1qd3x1b	231	5	with	with	IN
cord-252230-s1qd3x1b	231	6	epidemiological	epidemiological	JJ
cord-252230-s1qd3x1b	231	7	observations	observation	NNS
cord-252230-s1qd3x1b	231	8	suggesting	suggest	VBG
cord-252230-s1qd3x1b	231	9	that	that	IN
cord-252230-s1qd3x1b	231	10	IBD	IBD	NNP
cord-252230-s1qd3x1b	231	11	is	be	VBZ
cord-252230-s1qd3x1b	231	12	caused	cause	VBN
cord-252230-s1qd3x1b	231	13	by	by	IN
cord-252230-s1qd3x1b	231	14	the	the	DT
cord-252230-s1qd3x1b	231	15	confluence	confluence	NN
cord-252230-s1qd3x1b	231	16	of	of	IN
cord-252230-s1qd3x1b	231	17	multiple	multiple	JJ
cord-252230-s1qd3x1b	231	18	genetic	genetic	JJ
cord-252230-s1qd3x1b	231	19	and	and	CC
cord-252230-s1qd3x1b	231	20	environmental	environmental	JJ
cord-252230-s1qd3x1b	231	21	susceptibility	susceptibility	NN
cord-252230-s1qd3x1b	231	22	factors	factor	NNS
cord-252230-s1qd3x1b	231	23	.	.	.
cord-252230-s1qd3x1b	232	1	Several	several	JJ
cord-252230-s1qd3x1b	232	2	findings	finding	NNS
cord-252230-s1qd3x1b	232	3	support	support	VBP
cord-252230-s1qd3x1b	232	4	the	the	DT
cord-252230-s1qd3x1b	232	5	idea	idea	NN
cord-252230-s1qd3x1b	232	6	that	that	IN
cord-252230-s1qd3x1b	232	7	the	the	DT
cord-252230-s1qd3x1b	232	8	classic	classic	JJ
cord-252230-s1qd3x1b	232	9	autophagy	autophagy	NN
cord-252230-s1qd3x1b	232	10	function	function	NN
cord-252230-s1qd3x1b	232	11	of	of	IN
cord-252230-s1qd3x1b	232	12	ATG16L1	ATG16L1	NNS
cord-252230-s1qd3x1b	232	13	is	be	VBZ
cord-252230-s1qd3x1b	232	14	critical	critical	JJ
cord-252230-s1qd3x1b	232	15	for	for	IN
cord-252230-s1qd3x1b	232	16	protecting	protect	VBG
cord-252230-s1qd3x1b	232	17	the	the	DT
cord-252230-s1qd3x1b	232	18	epithelial	epithelial	JJ
cord-252230-s1qd3x1b	232	19	barrier	barrier	NN
cord-252230-s1qd3x1b	232	20	and	and	CC
cord-252230-s1qd3x1b	232	21	preventing	prevent	VBG
cord-252230-s1qd3x1b	232	22	a	a	DT
cord-252230-s1qd3x1b	232	23	sustained	sustained	JJ
cord-252230-s1qd3x1b	232	24	immune	immune	JJ
cord-252230-s1qd3x1b	232	25	reaction	reaction	NN
cord-252230-s1qd3x1b	232	26	.	.	.
cord-252230-s1qd3x1b	233	1	ATG	ATG	NNP
cord-252230-s1qd3x1b	233	2	-	-	HYPH
cord-252230-s1qd3x1b	233	3	deficient	deficient	JJ
cord-252230-s1qd3x1b	233	4	Paneth	Paneth	NNP
cord-252230-s1qd3x1b	233	5	cells	cell	NNS
cord-252230-s1qd3x1b	233	6	display	display	VBP
cord-252230-s1qd3x1b	233	7	unresolved	unresolved	JJ
cord-252230-s1qd3x1b	233	8	ER	ER	NNP
cord-252230-s1qd3x1b	233	9	stress	stress	NN
cord-252230-s1qd3x1b	233	10	and	and	CC
cord-252230-s1qd3x1b	233	11	mitochondrial	mitochondrial	JJ
cord-252230-s1qd3x1b	233	12	damage	damage	NN
cord-252230-s1qd3x1b	233	13	that	that	WDT
cord-252230-s1qd3x1b	233	14	contribute	contribute	VBP
cord-252230-s1qd3x1b	233	15	to	to	IN
cord-252230-s1qd3x1b	233	16	necroptosis	necroptosis	NNP
cord-252230-s1qd3x1b	233	17	,	,	,
cord-252230-s1qd3x1b	233	18	a	a	DT
cord-252230-s1qd3x1b	233	19	type	type	NN
cord-252230-s1qd3x1b	233	20	of	of	IN
cord-252230-s1qd3x1b	233	21	programmed	programmed	JJ
cord-252230-s1qd3x1b	233	22	necrotic	necrotic	JJ
cord-252230-s1qd3x1b	233	23	cell	cell	NN
cord-252230-s1qd3x1b	233	24	death	death	NN
cord-252230-s1qd3x1b	233	25	(	(	-LRB-
cord-252230-s1qd3x1b	233	26	Diamanti	Diamanti	NNP
cord-252230-s1qd3x1b	233	27	et	et	FW
cord-252230-s1qd3x1b	233	28	al	al	NNP
cord-252230-s1qd3x1b	233	29	.	.	.
cord-252230-s1qd3x1b	234	1	,	,	,
cord-252230-s1qd3x1b	234	2	2017	2017	CD
cord-252230-s1qd3x1b	234	3	;	;	:
cord-252230-s1qd3x1b	234	4	Matsuzawa	Matsuzawa	NNP
cord-252230-s1qd3x1b	234	5	-	-	HYPH
cord-252230-s1qd3x1b	234	6	Ishimoto	Ishimoto	NNP
cord-252230-s1qd3x1b	234	7	et	et	NNP
cord-252230-s1qd3x1b	234	8	al	al	NNP
cord-252230-s1qd3x1b	234	9	.	.	NNP
cord-252230-s1qd3x1b	234	10	,	,	,
cord-252230-s1qd3x1b	234	11	2017	2017	CD
cord-252230-s1qd3x1b	234	12	;	;	:
cord-252230-s1qd3x1b	234	13	Tschurtschenthaler	Tschurtschenthaler	NNP
cord-252230-s1qd3x1b	234	14	et	et	NNP
cord-252230-s1qd3x1b	234	15	al	al	NNP
cord-252230-s1qd3x1b	234	16	.	.	NNP
cord-252230-s1qd3x1b	234	17	,	,	,
cord-252230-s1qd3x1b	234	18	2017	2017	CD
cord-252230-s1qd3x1b	234	19	)	)	-RRB-
cord-252230-s1qd3x1b	234	20	.	.	.
cord-252230-s1qd3x1b	235	1	These	these	DT
cord-252230-s1qd3x1b	235	2	observations	observation	NNS
cord-252230-s1qd3x1b	235	3	suggest	suggest	VBP
cord-252230-s1qd3x1b	235	4	that	that	IN
cord-252230-s1qd3x1b	235	5	the	the	DT
cord-252230-s1qd3x1b	235	6	organelle	organelle	NN
cord-252230-s1qd3x1b	235	7	homeostasis	homeostasis	NN
cord-252230-s1qd3x1b	235	8	function	function	NN
cord-252230-s1qd3x1b	235	9	of	of	IN
cord-252230-s1qd3x1b	235	10	autophagy	autophagy	NN
cord-252230-s1qd3x1b	235	11	is	be	VBZ
cord-252230-s1qd3x1b	235	12	important	important	JJ
cord-252230-s1qd3x1b	235	13	to	to	TO
cord-252230-s1qd3x1b	235	14	counteract	counteract	VB
cord-252230-s1qd3x1b	235	15	the	the	DT
cord-252230-s1qd3x1b	235	16	secretory	secretory	JJ
cord-252230-s1qd3x1b	235	17	burden	burden	NN
cord-252230-s1qd3x1b	235	18	of	of	IN
cord-252230-s1qd3x1b	235	19	this	this	DT
cord-252230-s1qd3x1b	235	20	highly	highly	RB
cord-252230-s1qd3x1b	235	21	differentiated	differentiated	JJ
cord-252230-s1qd3x1b	235	22	cell	cell	NN
cord-252230-s1qd3x1b	235	23	type	type	NN
cord-252230-s1qd3x1b	235	24	and	and	CC
cord-252230-s1qd3x1b	235	25	prevent	prevent	VB
cord-252230-s1qd3x1b	235	26	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	235	27	sequelae	sequela	NNS
cord-252230-s1qd3x1b	235	28	.	.	.
cord-252230-s1qd3x1b	236	1	Also	also	RB
cord-252230-s1qd3x1b	236	2	,	,	,
cord-252230-s1qd3x1b	236	3	ATGs	atg	NNS
cord-252230-s1qd3x1b	236	4	are	be	VBP
cord-252230-s1qd3x1b	236	5	generally	generally	RB
cord-252230-s1qd3x1b	236	6	required	require	VBN
cord-252230-s1qd3x1b	236	7	to	to	TO
cord-252230-s1qd3x1b	236	8	protect	protect	VB
cord-252230-s1qd3x1b	236	9	the	the	DT
cord-252230-s1qd3x1b	236	10	epithelial	epithelial	JJ
cord-252230-s1qd3x1b	236	11	barrier	barrier	NN
cord-252230-s1qd3x1b	236	12	,	,	,
cord-252230-s1qd3x1b	236	13	potentially	potentially	RB
cord-252230-s1qd3x1b	236	14	through	through	IN
cord-252230-s1qd3x1b	236	15	xenophagy	xenophagy	NNS
cord-252230-s1qd3x1b	236	16	or	or	CC
cord-252230-s1qd3x1b	236	17	mediating	mediate	VBG
cord-252230-s1qd3x1b	236	18	mucus	mucus	NN
cord-252230-s1qd3x1b	236	19	production	production	NN
cord-252230-s1qd3x1b	236	20	by	by	IN
cord-252230-s1qd3x1b	236	21	goblet	goblet	NN
cord-252230-s1qd3x1b	236	22	cells	cell	NNS
cord-252230-s1qd3x1b	236	23	(	(	-LRB-
cord-252230-s1qd3x1b	236	24	Benjamin	Benjamin	NNP
cord-252230-s1qd3x1b	236	25	et	et	NNP
cord-252230-s1qd3x1b	236	26	al	al	NNP
cord-252230-s1qd3x1b	236	27	.	.	NNP
cord-252230-s1qd3x1b	236	28	,	,	,
cord-252230-s1qd3x1b	236	29	2013	2013	CD
cord-252230-s1qd3x1b	236	30	;	;	:
cord-252230-s1qd3x1b	236	31	Conway	Conway	NNP
cord-252230-s1qd3x1b	236	32	et	et	NNP
cord-252230-s1qd3x1b	236	33	al	al	NNP
cord-252230-s1qd3x1b	236	34	.	.	NNP
cord-252230-s1qd3x1b	236	35	,	,	,
cord-252230-s1qd3x1b	236	36	2013b	2013b	CD
cord-252230-s1qd3x1b	236	37	;	;	:
cord-252230-s1qd3x1b	236	38	Patel	Patel	NNP
cord-252230-s1qd3x1b	236	39	et	et	NNP
cord-252230-s1qd3x1b	236	40	al	al	NNP
cord-252230-s1qd3x1b	236	41	.	.	NNP
cord-252230-s1qd3x1b	236	42	,	,	,
cord-252230-s1qd3x1b	236	43	2013	2013	CD
cord-252230-s1qd3x1b	236	44	)	)	-RRB-
cord-252230-s1qd3x1b	236	45	.	.	.
cord-252230-s1qd3x1b	237	1	An	an	DT
cord-252230-s1qd3x1b	237	2	important	important	JJ
cord-252230-s1qd3x1b	237	3	role	role	NN
cord-252230-s1qd3x1b	237	4	for	for	IN
cord-252230-s1qd3x1b	237	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	237	6	in	in	IN
cord-252230-s1qd3x1b	237	7	immune	immune	JJ
cord-252230-s1qd3x1b	237	8	cells	cell	NNS
cord-252230-s1qd3x1b	237	9	should	should	MD
cord-252230-s1qd3x1b	237	10	also	also	RB
cord-252230-s1qd3x1b	237	11	be	be	VB
cord-252230-s1qd3x1b	237	12	considered	consider	VBN
cord-252230-s1qd3x1b	237	13	.	.	.
cord-252230-s1qd3x1b	238	1	Increased	increase	VBN
cord-252230-s1qd3x1b	238	2	inflammasome	inflammasome	NN
cord-252230-s1qd3x1b	238	3	activity	activity	NN
cord-252230-s1qd3x1b	238	4	in	in	IN
cord-252230-s1qd3x1b	238	5	macrophages	macrophage	NNS
cord-252230-s1qd3x1b	238	6	and	and	CC
cord-252230-s1qd3x1b	238	7	decreased	decrease	VBD
cord-252230-s1qd3x1b	238	8	differentiation	differentiation	NN
cord-252230-s1qd3x1b	238	9	of	of	IN
cord-252230-s1qd3x1b	238	10	antiinflammatory	antiinflammatory	JJ
cord-252230-s1qd3x1b	238	11	T	t	NN
cord-252230-s1qd3x1b	238	12	cells	cell	NNS
cord-252230-s1qd3x1b	238	13	are	be	VBP
cord-252230-s1qd3x1b	238	14	both	both	DT
cord-252230-s1qd3x1b	238	15	consequences	consequence	NNS
cord-252230-s1qd3x1b	238	16	of	of	IN
cord-252230-s1qd3x1b	238	17	ATG16L1	atg16l1	JJ
cord-252230-s1qd3x1b	238	18	inhibition	inhibition	NN
cord-252230-s1qd3x1b	238	19	,	,	,
cord-252230-s1qd3x1b	238	20	and	and	CC
cord-252230-s1qd3x1b	238	21	can	can	MD
cord-252230-s1qd3x1b	238	22	cause	cause	VB
cord-252230-s1qd3x1b	238	23	intestinal	intestinal	JJ
cord-252230-s1qd3x1b	238	24	inflammation	inflammation	NN
cord-252230-s1qd3x1b	238	25	(	(	-LRB-
cord-252230-s1qd3x1b	238	26	Saitoh	Saitoh	NNP
cord-252230-s1qd3x1b	238	27	et	et	FW
cord-252230-s1qd3x1b	238	28	al	al	NNP
cord-252230-s1qd3x1b	238	29	.	.	NNP
cord-252230-s1qd3x1b	238	30	,	,	,
cord-252230-s1qd3x1b	238	31	2008	2008	CD
cord-252230-s1qd3x1b	238	32	;	;	:
cord-252230-s1qd3x1b	238	33	Chu	Chu	NNP
cord-252230-s1qd3x1b	238	34	et	et	FW
cord-252230-s1qd3x1b	238	35	al	al	NNP
cord-252230-s1qd3x1b	238	36	.	.	NNP
cord-252230-s1qd3x1b	238	37	,	,	,
cord-252230-s1qd3x1b	238	38	2016	2016	CD
cord-252230-s1qd3x1b	238	39	;	;	.
cord-252230-s1qd3x1b	239	1	Kabat	Kabat	NNP
cord-252230-s1qd3x1b	239	2	et	et	NNP
cord-252230-s1qd3x1b	239	3	al	al	NNP
cord-252230-s1qd3x1b	239	4	.	.	NNP
cord-252230-s1qd3x1b	239	5	,	,	,
cord-252230-s1qd3x1b	239	6	2016	2016	CD
cord-252230-s1qd3x1b	239	7	)	)	-RRB-
cord-252230-s1qd3x1b	239	8	.	.	.
cord-252230-s1qd3x1b	240	1	However	however	RB
cord-252230-s1qd3x1b	240	2	,	,	,
cord-252230-s1qd3x1b	240	3	many	many	JJ
cord-252230-s1qd3x1b	240	4	of	of	IN
cord-252230-s1qd3x1b	240	5	these	these	DT
cord-252230-s1qd3x1b	240	6	studies	study	NNS
cord-252230-s1qd3x1b	240	7	rely	rely	VBP
cord-252230-s1qd3x1b	240	8	on	on	IN
cord-252230-s1qd3x1b	240	9	animal	animal	NN
cord-252230-s1qd3x1b	240	10	models	model	NNS
cord-252230-s1qd3x1b	240	11	in	in	IN
cord-252230-s1qd3x1b	240	12	which	which	WDT
cord-252230-s1qd3x1b	240	13	classic	classic	JJ
cord-252230-s1qd3x1b	240	14	autophagy	autophagy	NN
cord-252230-s1qd3x1b	240	15	and	and	CC
cord-252230-s1qd3x1b	240	16	related	related	JJ
cord-252230-s1qd3x1b	240	17	processes	process	NNS
cord-252230-s1qd3x1b	240	18	are	be	VBP
cord-252230-s1qd3x1b	240	19	difficult	difficult	JJ
cord-252230-s1qd3x1b	240	20	to	to	TO
cord-252230-s1qd3x1b	240	21	distinguish	distinguish	VB
cord-252230-s1qd3x1b	240	22	.	.	.
cord-252230-s1qd3x1b	241	1	ATG16L1	ATG16L1	NNP
cord-252230-s1qd3x1b	241	2	T300A	T300A	NNP
cord-252230-s1qd3x1b	241	3	disrupts	disrupt	VBZ
cord-252230-s1qd3x1b	241	4	secretory	secretory	JJ
cord-252230-s1qd3x1b	241	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	241	6	,	,	,
cord-252230-s1qd3x1b	241	7	leading	lead	VBG
cord-252230-s1qd3x1b	241	8	to	to	IN
cord-252230-s1qd3x1b	241	9	impaired	impair	VBN
cord-252230-s1qd3x1b	241	10	exocytosis	exocytosis	NN
cord-252230-s1qd3x1b	241	11	of	of	IN
cord-252230-s1qd3x1b	241	12	lysozyme	lysozyme	NNS
cord-252230-s1qd3x1b	241	13	from	from	IN
cord-252230-s1qd3x1b	241	14	Paneth	Paneth	NNP
cord-252230-s1qd3x1b	241	15	cells	cell	NNS
cord-252230-s1qd3x1b	241	16	during	during	IN
cord-252230-s1qd3x1b	241	17	Salmonella	Salmonella	NNP
cord-252230-s1qd3x1b	241	18	infection	infection	NN
cord-252230-s1qd3x1b	242	1	(	(	-LRB-
cord-252230-s1qd3x1b	242	2	Bel	Bel	NNP
cord-252230-s1qd3x1b	242	3	et	et	NNP
cord-252230-s1qd3x1b	242	4	al	al	NNP
cord-252230-s1qd3x1b	242	5	.	.	NNP
cord-252230-s1qd3x1b	242	6	,	,	,
cord-252230-s1qd3x1b	242	7	2017	2017	CD
cord-252230-s1qd3x1b	242	8	)	)	-RRB-
cord-252230-s1qd3x1b	242	9	,	,	,
cord-252230-s1qd3x1b	242	10	and	and	CC
cord-252230-s1qd3x1b	242	11	the	the	DT
cord-252230-s1qd3x1b	242	12	effect	effect	NN
cord-252230-s1qd3x1b	242	13	of	of	IN
cord-252230-s1qd3x1b	242	14	ATG16L1	atg16l1	JJ
cord-252230-s1qd3x1b	242	15	T300A	T300A	NNS
cord-252230-s1qd3x1b	242	16	on	on	IN
cord-252230-s1qd3x1b	242	17	the	the	DT
cord-252230-s1qd3x1b	242	18	necroptosis	necroptosis	NN
cord-252230-s1qd3x1b	242	19	signaling	signal	VBG
cord-252230-s1qd3x1b	242	20	complex	complex	JJ
cord-252230-s1qd3x1b	242	21	likely	likely	RB
cord-252230-s1qd3x1b	242	22	involves	involve	VBZ
cord-252230-s1qd3x1b	242	23	disruption	disruption	NN
cord-252230-s1qd3x1b	242	24	in	in	IN
cord-252230-s1qd3x1b	242	25	ATG	ATG	NNP
cord-252230-s1qd3x1b	242	26	-	-	HYPH
cord-252230-s1qd3x1b	242	27	mediating	mediate	VBG
cord-252230-s1qd3x1b	242	28	immune	immune	NN
cord-252230-s1qd3x1b	242	29	signaling	signaling	NN
cord-252230-s1qd3x1b	242	30	(	(	-LRB-
cord-252230-s1qd3x1b	242	31	Matsuzawa	Matsuzawa	NNP
cord-252230-s1qd3x1b	242	32	-	-	HYPH
cord-252230-s1qd3x1b	242	33	Ishimoto	Ishimoto	NNP
cord-252230-s1qd3x1b	242	34	et	et	NNP
cord-252230-s1qd3x1b	242	35	al	al	NNP
cord-252230-s1qd3x1b	242	36	.	.	NNP
cord-252230-s1qd3x1b	242	37	,	,	,
cord-252230-s1qd3x1b	242	38	2017	2017	CD
cord-252230-s1qd3x1b	242	39	)	)	-RRB-
cord-252230-s1qd3x1b	242	40	.	.	.
cord-252230-s1qd3x1b	243	1	In	in	IN
cord-252230-s1qd3x1b	243	2	addition	addition	NN
cord-252230-s1qd3x1b	243	3	to	to	IN
cord-252230-s1qd3x1b	243	4	being	be	VBG
cord-252230-s1qd3x1b	243	5	an	an	DT
cord-252230-s1qd3x1b	243	6	unstable	unstable	JJ
cord-252230-s1qd3x1b	243	7	protein	protein	NN
cord-252230-s1qd3x1b	243	8	,	,	,
cord-252230-s1qd3x1b	243	9	ATG16L1	ATG16L1	NNP
cord-252230-s1qd3x1b	243	10	T300A	T300A	NNP
cord-252230-s1qd3x1b	243	11	displays	display	NNS
cord-252230-s1qd3x1b	243	12	impaired	impair	VBN
cord-252230-s1qd3x1b	243	13	binding	bind	VBG
cord-252230-s1qd3x1b	243	14	with	with	IN
cord-252230-s1qd3x1b	243	15	TMEM59	TMEM59	NNP
cord-252230-s1qd3x1b	243	16	,	,	,
cord-252230-s1qd3x1b	243	17	a	a	DT
cord-252230-s1qd3x1b	243	18	transmembrane	transmembrane	NN
cord-252230-s1qd3x1b	243	19	protein	protein	NN
cord-252230-s1qd3x1b	243	20	that	that	WDT
cord-252230-s1qd3x1b	243	21	mediates	mediate	VBZ
cord-252230-s1qd3x1b	243	22	the	the	DT
cord-252230-s1qd3x1b	243	23	trafficking	trafficking	NN
cord-252230-s1qd3x1b	243	24	of	of	IN
cord-252230-s1qd3x1b	243	25	LC3	lc3	NN
cord-252230-s1qd3x1b	243	26	+	+	CC
cord-252230-s1qd3x1b	243	27	vesicles	vesicle	NNS
cord-252230-s1qd3x1b	243	28	through	through	IN
cord-252230-s1qd3x1b	243	29	a	a	DT
cord-252230-s1qd3x1b	243	30	process	process	NN
cord-252230-s1qd3x1b	243	31	distinct	distinct	JJ
cord-252230-s1qd3x1b	243	32	from	from	IN
cord-252230-s1qd3x1b	243	33	classic	classic	JJ
cord-252230-s1qd3x1b	243	34	autophagy	autophagy	NN
cord-252230-s1qd3x1b	244	1	(	(	-LRB-
cord-252230-s1qd3x1b	244	2	Boada	Boada	NNP
cord-252230-s1qd3x1b	244	3	-	-	HYPH
cord-252230-s1qd3x1b	244	4	Romero	Romero	NNP
cord-252230-s1qd3x1b	244	5	et	et	NNP
cord-252230-s1qd3x1b	244	6	al	al	NNP
cord-252230-s1qd3x1b	244	7	.	.	NNP
cord-252230-s1qd3x1b	244	8	,	,	,
cord-252230-s1qd3x1b	244	9	2016	2016	CD
cord-252230-s1qd3x1b	244	10	)	)	-RRB-
cord-252230-s1qd3x1b	244	11	.	.	.
cord-252230-s1qd3x1b	245	1	Also	also	RB
cord-252230-s1qd3x1b	245	2	,	,	,
cord-252230-s1qd3x1b	245	3	with	with	IN
cord-252230-s1qd3x1b	245	4	the	the	DT
cord-252230-s1qd3x1b	245	5	exception	exception	NN
cord-252230-s1qd3x1b	245	6	of	of	IN
cord-252230-s1qd3x1b	245	7	graft	graft	NN
cord-252230-s1qd3x1b	245	8	-	-	HYPH
cord-252230-s1qd3x1b	245	9	versus	versus	IN
cord-252230-s1qd3x1b	245	10	-	-	HYPH
cord-252230-s1qd3x1b	245	11	host	host	NN
cord-252230-s1qd3x1b	245	12	disease	disease	NN
cord-252230-s1qd3x1b	245	13	(	(	-LRB-
cord-252230-s1qd3x1b	245	14	Hubbard	Hubbard	NNP
cord-252230-s1qd3x1b	245	15	-	-	HYPH
cord-252230-s1qd3x1b	245	16	Lucey	Lucey	NNP
cord-252230-s1qd3x1b	245	17	et	et	NNP
cord-252230-s1qd3x1b	245	18	al	al	NNP
cord-252230-s1qd3x1b	245	19	.	.	NNP
cord-252230-s1qd3x1b	245	20	,	,	,
cord-252230-s1qd3x1b	245	21	2014	2014	CD
cord-252230-s1qd3x1b	245	22	)	)	-RRB-
cord-252230-s1qd3x1b	245	23	,	,	,
cord-252230-s1qd3x1b	245	24	the	the	DT
cord-252230-s1qd3x1b	245	25	IBD	IBD	NNP
cord-252230-s1qd3x1b	245	26	variant	variant	NN
cord-252230-s1qd3x1b	245	27	of	of	IN
cord-252230-s1qd3x1b	245	28	ATG16L1	ATG16L1	NNS
cord-252230-s1qd3x1b	245	29	is	be	VBZ
cord-252230-s1qd3x1b	245	30	not	not	RB
cord-252230-s1qd3x1b	245	31	linked	link	VBN
cord-252230-s1qd3x1b	245	32	to	to	IN
cord-252230-s1qd3x1b	245	33	other	other	JJ
cord-252230-s1qd3x1b	245	34	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	245	35	disorders	disorder	NNS
cord-252230-s1qd3x1b	245	36	associated	associate	VBN
cord-252230-s1qd3x1b	245	37	with	with	IN
cord-252230-s1qd3x1b	245	38	autophagy	autophagy	NN
cord-252230-s1qd3x1b	245	39	dysfunction	dysfunction	NN
cord-252230-s1qd3x1b	245	40	,	,	,
cord-252230-s1qd3x1b	245	41	such	such	JJ
cord-252230-s1qd3x1b	245	42	as	as	IN
cord-252230-s1qd3x1b	245	43	Vici	Vici	NNP
cord-252230-s1qd3x1b	245	44	syndrome	syndrome	NN
cord-252230-s1qd3x1b	245	45	.	.	.
cord-252230-s1qd3x1b	246	1	Thus	thus	RB
cord-252230-s1qd3x1b	246	2	,	,	,
cord-252230-s1qd3x1b	246	3	investigating	investigate	VBG
cord-252230-s1qd3x1b	246	4	the	the	DT
cord-252230-s1qd3x1b	246	5	potential	potential	JJ
cord-252230-s1qd3x1b	246	6	nonautophagic	nonautophagic	JJ
cord-252230-s1qd3x1b	246	7	functions	function	NNS
cord-252230-s1qd3x1b	246	8	of	of	IN
cord-252230-s1qd3x1b	246	9	ATG16L1	ATG16L1	NNS
cord-252230-s1qd3x1b	246	10	in	in	IN
cord-252230-s1qd3x1b	246	11	maintaining	maintain	VBG
cord-252230-s1qd3x1b	246	12	the	the	DT
cord-252230-s1qd3x1b	246	13	intestinal	intestinal	JJ
cord-252230-s1qd3x1b	246	14	barrier	barrier	NN
cord-252230-s1qd3x1b	246	15	remains	remain	VBZ
cord-252230-s1qd3x1b	246	16	a	a	DT
cord-252230-s1qd3x1b	246	17	critically	critically	RB
cord-252230-s1qd3x1b	246	18	important	important	JJ
cord-252230-s1qd3x1b	246	19	future	future	JJ
cord-252230-s1qd3x1b	246	20	direction	direction	NN
cord-252230-s1qd3x1b	246	21	.	.	.
cord-252230-s1qd3x1b	247	1	RA	RA	NNP
cord-252230-s1qd3x1b	247	2	is	be	VBZ
cord-252230-s1qd3x1b	247	3	an	an	DT
cord-252230-s1qd3x1b	247	4	autoimmune	autoimmune	JJ
cord-252230-s1qd3x1b	247	5	disease	disease	NN
cord-252230-s1qd3x1b	247	6	that	that	WDT
cord-252230-s1qd3x1b	247	7	primarily	primarily	RB
cord-252230-s1qd3x1b	247	8	affects	affect	VBZ
cord-252230-s1qd3x1b	247	9	the	the	DT
cord-252230-s1qd3x1b	247	10	joints	joint	NNS
cord-252230-s1qd3x1b	247	11	and	and	CC
cord-252230-s1qd3x1b	247	12	is	be	VBZ
cord-252230-s1qd3x1b	247	13	associated	associate	VBN
cord-252230-s1qd3x1b	247	14	with	with	IN
cord-252230-s1qd3x1b	247	15	the	the	DT
cord-252230-s1qd3x1b	247	16	presence	presence	NN
cord-252230-s1qd3x1b	247	17	of	of	IN
cord-252230-s1qd3x1b	247	18	autoantibodies	autoantibody	NNS
cord-252230-s1qd3x1b	247	19	that	that	WDT
cord-252230-s1qd3x1b	247	20	are	be	VBP
cord-252230-s1qd3x1b	247	21	reactive	reactive	JJ
cord-252230-s1qd3x1b	247	22	to	to	IN
cord-252230-s1qd3x1b	247	23	citrullinated	citrullinate	VBN
cord-252230-s1qd3x1b	247	24	peptides	peptide	NNS
cord-252230-s1qd3x1b	247	25	that	that	WDT
cord-252230-s1qd3x1b	247	26	are	be	VBP
cord-252230-s1qd3x1b	247	27	presented	present	VBN
cord-252230-s1qd3x1b	247	28	by	by	IN
cord-252230-s1qd3x1b	247	29	MHC	MHC	NNP
cord-252230-s1qd3x1b	247	30	-	-	HYPH
cord-252230-s1qd3x1b	247	31	II	II	NNP
cord-252230-s1qd3x1b	247	32	molecules	molecule	NNS
cord-252230-s1qd3x1b	247	33	.	.	.
cord-252230-s1qd3x1b	248	1	In	in	IN
cord-252230-s1qd3x1b	248	2	contrast	contrast	NN
cord-252230-s1qd3x1b	248	3	to	to	IN
cord-252230-s1qd3x1b	248	4	IBD	IBD	NNP
cord-252230-s1qd3x1b	248	5	,	,	,
cord-252230-s1qd3x1b	248	6	ATG	ATG	NNP
cord-252230-s1qd3x1b	248	7	function	function	NN
cord-252230-s1qd3x1b	248	8	may	may	MD
cord-252230-s1qd3x1b	248	9	promote	promote	VB
cord-252230-s1qd3x1b	248	10	RA	RA	NNP
cord-252230-s1qd3x1b	248	11	.	.	.
cord-252230-s1qd3x1b	249	1	ATG5	ATG5	NNP
cord-252230-s1qd3x1b	249	2	is	be	VBZ
cord-252230-s1qd3x1b	249	3	required	require	VBN
cord-252230-s1qd3x1b	249	4	for	for	IN
cord-252230-s1qd3x1b	249	5	generation	generation	NN
cord-252230-s1qd3x1b	249	6	of	of	IN
cord-252230-s1qd3x1b	249	7	citrullinated	citrullinate	VBN
cord-252230-s1qd3x1b	249	8	antigens	antigen	NNS
cord-252230-s1qd3x1b	249	9	by	by	IN
cord-252230-s1qd3x1b	249	10	peptidylarginine	peptidylarginine	JJ
cord-252230-s1qd3x1b	249	11	deiminases	deiminase	NNS
cord-252230-s1qd3x1b	249	12	,	,	,
cord-252230-s1qd3x1b	249	13	potentially	potentially	RB
cord-252230-s1qd3x1b	249	14	by	by	IN
cord-252230-s1qd3x1b	249	15	mediating	mediate	VBG
cord-252230-s1qd3x1b	249	16	the	the	DT
cord-252230-s1qd3x1b	249	17	trafficking	trafficking	NN
cord-252230-s1qd3x1b	249	18	of	of	IN
cord-252230-s1qd3x1b	249	19	these	these	DT
cord-252230-s1qd3x1b	249	20	enzymes	enzyme	NNS
cord-252230-s1qd3x1b	249	21	to	to	IN
cord-252230-s1qd3x1b	249	22	MHC	MHC	NNP
cord-252230-s1qd3x1b	249	23	-	-	HYPH
cord-252230-s1qd3x1b	249	24	II	II	NNP
cord-252230-s1qd3x1b	249	25	antigen	antigen	NN
cord-252230-s1qd3x1b	249	26	loading	loading	NN
cord-252230-s1qd3x1b	249	27	compartments	compartment	NNS
cord-252230-s1qd3x1b	249	28	(	(	-LRB-
cord-252230-s1qd3x1b	249	29	Ireland	Ireland	NNP
cord-252230-s1qd3x1b	249	30	and	and	CC
cord-252230-s1qd3x1b	249	31	Unanue	Unanue	NNP
cord-252230-s1qd3x1b	249	32	,	,	,
cord-252230-s1qd3x1b	249	33	2011	2011	CD
cord-252230-s1qd3x1b	249	34	)	)	-RRB-
cord-252230-s1qd3x1b	249	35	.	.	.
cord-252230-s1qd3x1b	250	1	CTLA4	CTLA4	NNP
cord-252230-s1qd3x1b	250	2	on	on	IN
cord-252230-s1qd3x1b	250	3	anti	anti	JJ
cord-252230-s1qd3x1b	250	4	-	-	JJ
cord-252230-s1qd3x1b	250	5	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	250	6	T	t	NN
cord-252230-s1qd3x1b	250	7	cells	cell	NNS
cord-252230-s1qd3x1b	250	8	binds	bind	VBZ
cord-252230-s1qd3x1b	250	9	B7	b7	NN
cord-252230-s1qd3x1b	250	10	molecules	molecule	NNS
cord-252230-s1qd3x1b	250	11	on	on	IN
cord-252230-s1qd3x1b	250	12	dendritic	dendritic	JJ
cord-252230-s1qd3x1b	250	13	cells	cell	NNS
cord-252230-s1qd3x1b	250	14	to	to	TO
cord-252230-s1qd3x1b	250	15	inhibit	inhibit	VB
cord-252230-s1qd3x1b	250	16	LC3	lc3	JJ
cord-252230-s1qd3x1b	250	17	expression	expression	NN
cord-252230-s1qd3x1b	250	18	and	and	CC
cord-252230-s1qd3x1b	250	19	autophagy	autophagy	NN
cord-252230-s1qd3x1b	250	20	,	,	,
cord-252230-s1qd3x1b	250	21	which	which	WDT
cord-252230-s1qd3x1b	250	22	dampens	dampen	VBZ
cord-252230-s1qd3x1b	250	23	the	the	DT
cord-252230-s1qd3x1b	250	24	capacity	capacity	NN
cord-252230-s1qd3x1b	250	25	to	to	TO
cord-252230-s1qd3x1b	250	26	present	present	JJ
cord-252230-s1qd3x1b	250	27	antigens	antigen	NNS
cord-252230-s1qd3x1b	250	28	(	(	-LRB-
cord-252230-s1qd3x1b	250	29	Alissafi	Alissafi	NNP
cord-252230-s1qd3x1b	250	30	et	et	NNP
cord-252230-s1qd3x1b	250	31	al	al	NNP
cord-252230-s1qd3x1b	250	32	.	.	NNP
cord-252230-s1qd3x1b	250	33	,	,	,
cord-252230-s1qd3x1b	250	34	2017	2017	CD
cord-252230-s1qd3x1b	250	35	)	)	-RRB-
cord-252230-s1qd3x1b	250	36	.	.	.
cord-252230-s1qd3x1b	251	1	The	the	DT
cord-252230-s1qd3x1b	251	2	CTLA4-Ig	CTLA4-Ig	NNP
cord-252230-s1qd3x1b	251	3	fusion	fusion	NN
cord-252230-s1qd3x1b	251	4	molecule	molecule	NN
cord-252230-s1qd3x1b	251	5	abatacept	abatacept	NN
cord-252230-s1qd3x1b	251	6	,	,	,
cord-252230-s1qd3x1b	251	7	which	which	WDT
cord-252230-s1qd3x1b	251	8	is	be	VBZ
cord-252230-s1qd3x1b	251	9	used	use	VBN
cord-252230-s1qd3x1b	251	10	to	to	TO
cord-252230-s1qd3x1b	251	11	treat	treat	VB
cord-252230-s1qd3x1b	251	12	RA	RA	NNP
cord-252230-s1qd3x1b	251	13	,	,	,
cord-252230-s1qd3x1b	251	14	also	also	RB
cord-252230-s1qd3x1b	251	15	inhibits	inhibit	VBZ
cord-252230-s1qd3x1b	251	16	ATG	ATG	NNP
cord-252230-s1qd3x1b	251	17	-	-	HYPH
cord-252230-s1qd3x1b	251	18	mediated	mediate	VBN
cord-252230-s1qd3x1b	251	19	antigen	antigen	NN
cord-252230-s1qd3x1b	251	20	presentation	presentation	NN
cord-252230-s1qd3x1b	251	21	by	by	IN
cord-252230-s1qd3x1b	251	22	dendritic	dendritic	JJ
cord-252230-s1qd3x1b	251	23	cells	cell	NNS
cord-252230-s1qd3x1b	251	24	,	,	,
cord-252230-s1qd3x1b	251	25	suggesting	suggest	VBG
cord-252230-s1qd3x1b	251	26	that	that	IN
cord-252230-s1qd3x1b	251	27	dampening	dampen	VBG
cord-252230-s1qd3x1b	251	28	autophagy	autophagy	NN
cord-252230-s1qd3x1b	251	29	is	be	VBZ
cord-252230-s1qd3x1b	251	30	part	part	NN
cord-252230-s1qd3x1b	251	31	of	of	IN
cord-252230-s1qd3x1b	251	32	the	the	DT
cord-252230-s1qd3x1b	251	33	mechanism	mechanism	NN
cord-252230-s1qd3x1b	251	34	of	of	IN
cord-252230-s1qd3x1b	251	35	action	action	NN
cord-252230-s1qd3x1b	251	36	of	of	IN
cord-252230-s1qd3x1b	251	37	this	this	DT
cord-252230-s1qd3x1b	251	38	drug	drug	NN
cord-252230-s1qd3x1b	251	39	(	(	-LRB-
cord-252230-s1qd3x1b	251	40	Alissafi	Alissafi	NNP
cord-252230-s1qd3x1b	251	41	et	et	NNP
cord-252230-s1qd3x1b	251	42	al	al	NNP
cord-252230-s1qd3x1b	251	43	.	.	NNP
cord-252230-s1qd3x1b	251	44	,	,	,
cord-252230-s1qd3x1b	251	45	2017	2017	CD
cord-252230-s1qd3x1b	251	46	)	)	-RRB-
cord-252230-s1qd3x1b	251	47	.	.	.
cord-252230-s1qd3x1b	252	1	Because	because	IN
cord-252230-s1qd3x1b	252	2	it	-PRON-	PRP
cord-252230-s1qd3x1b	252	3	is	be	VBZ
cord-252230-s1qd3x1b	252	4	currently	currently	RB
cord-252230-s1qd3x1b	252	5	unclear	unclear	JJ
cord-252230-s1qd3x1b	252	6	when	when	WRB
cord-252230-s1qd3x1b	252	7	autophagy	autophagy	NN
cord-252230-s1qd3x1b	252	8	or	or	CC
cord-252230-s1qd3x1b	252	9	an	an	DT
cord-252230-s1qd3x1b	252	10	autophagy	autophagy	NN
cord-252230-s1qd3x1b	252	11	-	-	HYPH
cord-252230-s1qd3x1b	252	12	related	relate	VBN
cord-252230-s1qd3x1b	252	13	process	process	NN
cord-252230-s1qd3x1b	252	14	such	such	JJ
cord-252230-s1qd3x1b	252	15	as	as	IN
cord-252230-s1qd3x1b	252	16	LAP	LAP	NNP
cord-252230-s1qd3x1b	252	17	mediates	mediate	VBZ
cord-252230-s1qd3x1b	252	18	antigen	antigen	NN
cord-252230-s1qd3x1b	252	19	presentation	presentation	NN
cord-252230-s1qd3x1b	252	20	,	,	,
cord-252230-s1qd3x1b	252	21	an	an	DT
cord-252230-s1qd3x1b	252	22	important	important	JJ
cord-252230-s1qd3x1b	252	23	future	future	JJ
cord-252230-s1qd3x1b	252	24	direction	direction	NN
cord-252230-s1qd3x1b	252	25	will	will	MD
cord-252230-s1qd3x1b	252	26	be	be	VB
cord-252230-s1qd3x1b	252	27	to	to	TO
cord-252230-s1qd3x1b	252	28	determine	determine	VB
cord-252230-s1qd3x1b	252	29	which	which	WDT
cord-252230-s1qd3x1b	252	30	ATGs	atg	NNS
cord-252230-s1qd3x1b	252	31	are	be	VBP
cord-252230-s1qd3x1b	252	32	necessary	necessary	JJ
cord-252230-s1qd3x1b	252	33	for	for	IN
cord-252230-s1qd3x1b	252	34	autoantigen	autoantigen	NN
cord-252230-s1qd3x1b	252	35	presentation	presentation	NN
cord-252230-s1qd3x1b	252	36	,	,	,
cord-252230-s1qd3x1b	252	37	and	and	CC
cord-252230-s1qd3x1b	252	38	whether	whether	IN
cord-252230-s1qd3x1b	252	39	this	this	DT
cord-252230-s1qd3x1b	252	40	differs	differ	VBZ
cord-252230-s1qd3x1b	252	41	among	among	IN
cord-252230-s1qd3x1b	252	42	cell	cell	NN
cord-252230-s1qd3x1b	252	43	types	type	NNS
cord-252230-s1qd3x1b	252	44	.	.	.
cord-252230-s1qd3x1b	253	1	Polymorphisms	polymorphism	NNS
cord-252230-s1qd3x1b	253	2	in	in	IN
cord-252230-s1qd3x1b	253	3	a	a	DT
cord-252230-s1qd3x1b	253	4	noncoding	noncoding	JJ
cord-252230-s1qd3x1b	253	5	region	region	NN
cord-252230-s1qd3x1b	253	6	of	of	IN
cord-252230-s1qd3x1b	253	7	ATG5	ATG5	NNP
cord-252230-s1qd3x1b	253	8	is	be	VBZ
cord-252230-s1qd3x1b	253	9	associated	associate	VBN
cord-252230-s1qd3x1b	253	10	with	with	IN
cord-252230-s1qd3x1b	253	11	SLE	SLE	NNP
cord-252230-s1qd3x1b	253	12	,	,	,
cord-252230-s1qd3x1b	253	13	a	a	DT
cord-252230-s1qd3x1b	253	14	multiorgan	multiorgan	NNP
cord-252230-s1qd3x1b	253	15	autoimmune	autoimmune	JJ
cord-252230-s1qd3x1b	253	16	disease	disease	NN
cord-252230-s1qd3x1b	253	17	characterized	characterize	VBN
cord-252230-s1qd3x1b	253	18	by	by	IN
cord-252230-s1qd3x1b	253	19	antinuclear	antinuclear	JJ
cord-252230-s1qd3x1b	253	20	antibodies	antibody	NNS
cord-252230-s1qd3x1b	253	21	,	,	,
cord-252230-s1qd3x1b	253	22	indicative	indicative	JJ
cord-252230-s1qd3x1b	253	23	of	of	IN
cord-252230-s1qd3x1b	253	24	improper	improper	JJ
cord-252230-s1qd3x1b	253	25	immune	immune	JJ
cord-252230-s1qd3x1b	253	26	activation	activation	NN
cord-252230-s1qd3x1b	253	27	toward	toward	IN
cord-252230-s1qd3x1b	253	28	cellular	cellular	JJ
cord-252230-s1qd3x1b	253	29	contents	content	NNS
cord-252230-s1qd3x1b	253	30	(	(	-LRB-
cord-252230-s1qd3x1b	253	31	Harley	Harley	NNP
cord-252230-s1qd3x1b	253	32	et	et	NNP
cord-252230-s1qd3x1b	253	33	al	al	NNP
cord-252230-s1qd3x1b	253	34	.	.	NNP
cord-252230-s1qd3x1b	253	35	,	,	,
cord-252230-s1qd3x1b	253	36	2008	2008	CD
cord-252230-s1qd3x1b	253	37	)	)	-RRB-
cord-252230-s1qd3x1b	253	38	.	.	.
cord-252230-s1qd3x1b	254	1	ATG5	atg5	JJ
cord-252230-s1qd3x1b	254	2	in	in	IN
cord-252230-s1qd3x1b	254	3	B	b	NN
cord-252230-s1qd3x1b	254	4	cells	cell	NNS
cord-252230-s1qd3x1b	254	5	is	be	VBZ
cord-252230-s1qd3x1b	254	6	required	require	VBN
cord-252230-s1qd3x1b	254	7	for	for	IN
cord-252230-s1qd3x1b	254	8	autoantibody	autoantibody	NNP
cord-252230-s1qd3x1b	254	9	generation	generation	NN
cord-252230-s1qd3x1b	254	10	in	in	IN
cord-252230-s1qd3x1b	254	11	the	the	DT
cord-252230-s1qd3x1b	254	12	Lpr	Lpr	NNP
cord-252230-s1qd3x1b	254	13	and	and	CC
cord-252230-s1qd3x1b	254	14	Tlr7	Tlr7	NNP
cord-252230-s1qd3x1b	254	15	transgenic	transgenic	JJ
cord-252230-s1qd3x1b	254	16	mouse	mouse	NN
cord-252230-s1qd3x1b	254	17	models	model	NNS
cord-252230-s1qd3x1b	254	18	of	of	IN
cord-252230-s1qd3x1b	254	19	SLE	SLE	NNP
cord-252230-s1qd3x1b	255	1	(	(	-LRB-
cord-252230-s1qd3x1b	255	2	Weindel	Weindel	NNP
cord-252230-s1qd3x1b	255	3	et	et	NNP
cord-252230-s1qd3x1b	255	4	al	al	NNP
cord-252230-s1qd3x1b	255	5	.	.	.
cord-252230-s1qd3x1b	256	1	,	,	,
cord-252230-s1qd3x1b	256	2	2015	2015	CD
cord-252230-s1qd3x1b	256	3	;	;	:
cord-252230-s1qd3x1b	256	4	Arnold	Arnold	NNP
cord-252230-s1qd3x1b	256	5	et	et	NNP
cord-252230-s1qd3x1b	256	6	al	al	NNP
cord-252230-s1qd3x1b	256	7	.	.	NNP
cord-252230-s1qd3x1b	256	8	,	,	,
cord-252230-s1qd3x1b	256	9	2016	2016	CD
cord-252230-s1qd3x1b	256	10	)	)	-RRB-
cord-252230-s1qd3x1b	256	11	,	,	,
cord-252230-s1qd3x1b	256	12	consistent	consistent	JJ
cord-252230-s1qd3x1b	256	13	with	with	IN
cord-252230-s1qd3x1b	256	14	the	the	DT
cord-252230-s1qd3x1b	256	15	role	role	NN
cord-252230-s1qd3x1b	256	16	of	of	IN
cord-252230-s1qd3x1b	256	17	autophagy	autophagy	NN
cord-252230-s1qd3x1b	256	18	in	in	IN
cord-252230-s1qd3x1b	256	19	supporting	support	VBG
cord-252230-s1qd3x1b	256	20	the	the	DT
cord-252230-s1qd3x1b	256	21	secretory	secretory	JJ
cord-252230-s1qd3x1b	256	22	burden	burden	NN
cord-252230-s1qd3x1b	256	23	and	and	CC
cord-252230-s1qd3x1b	256	24	organelle	organelle	NN
cord-252230-s1qd3x1b	256	25	homeostasis	homeostasis	NN
cord-252230-s1qd3x1b	256	26	in	in	IN
cord-252230-s1qd3x1b	256	27	differentiated	differentiate	VBN
cord-252230-s1qd3x1b	256	28	B	b	NN
cord-252230-s1qd3x1b	256	29	cells	cell	NNS
cord-252230-s1qd3x1b	256	30	(	(	-LRB-
cord-252230-s1qd3x1b	256	31	Conway	Conway	NNP
cord-252230-s1qd3x1b	256	32	et	et	NNP
cord-252230-s1qd3x1b	256	33	al	al	NNP
cord-252230-s1qd3x1b	256	34	.	.	NNP
cord-252230-s1qd3x1b	256	35	,	,	,
cord-252230-s1qd3x1b	256	36	2013a	2013a	CD
cord-252230-s1qd3x1b	256	37	;	;	:
cord-252230-s1qd3x1b	256	38	Pengo	Pengo	NNP
cord-252230-s1qd3x1b	256	39	et	et	NNP
cord-252230-s1qd3x1b	256	40	al	al	NNP
cord-252230-s1qd3x1b	256	41	.	.	NNP
cord-252230-s1qd3x1b	256	42	,	,	,
cord-252230-s1qd3x1b	256	43	2013	2013	CD
cord-252230-s1qd3x1b	256	44	;	;	:
cord-252230-s1qd3x1b	257	1	Chen	Chen	NNP
cord-252230-s1qd3x1b	257	2	et	et	NNP
cord-252230-s1qd3x1b	257	3	al	al	NNP
cord-252230-s1qd3x1b	257	4	.	.	.
cord-252230-s1qd3x1b	258	1	,	,	,
cord-252230-s1qd3x1b	259	1	2014	2014	CD
cord-252230-s1qd3x1b	260	1	Chen	Chen	NNP
cord-252230-s1qd3x1b	260	2	et	et	NNP
cord-252230-s1qd3x1b	260	3	al	al	NNP
cord-252230-s1qd3x1b	260	4	.	.	.
cord-252230-s1qd3x1b	261	1	,	,	,
cord-252230-s1qd3x1b	261	2	,	,	,
cord-252230-s1qd3x1b	261	3	2015a	2015a	CD
cord-252230-s1qd3x1b	261	4	.	.	.
cord-252230-s1qd3x1b	262	1	In	in	IN
cord-252230-s1qd3x1b	262	2	contrast	contrast	NN
cord-252230-s1qd3x1b	262	3	to	to	IN
cord-252230-s1qd3x1b	262	4	this	this	DT
cord-252230-s1qd3x1b	262	5	proposed	propose	VBN
cord-252230-s1qd3x1b	262	6	role	role	NN
cord-252230-s1qd3x1b	262	7	of	of	IN
cord-252230-s1qd3x1b	262	8	autophagy	autophagy	NN
cord-252230-s1qd3x1b	262	9	in	in	IN
cord-252230-s1qd3x1b	262	10	B	b	NN
cord-252230-s1qd3x1b	262	11	cells	cell	NNS
cord-252230-s1qd3x1b	262	12	that	that	WDT
cord-252230-s1qd3x1b	262	13	facilitates	facilitate	VBZ
cord-252230-s1qd3x1b	262	14	SLE	SLE	NNP
cord-252230-s1qd3x1b	262	15	pathogenesis	pathogenesis	NN
cord-252230-s1qd3x1b	262	16	,	,	,
cord-252230-s1qd3x1b	262	17	the	the	DT
cord-252230-s1qd3x1b	262	18	genetic	genetic	JJ
cord-252230-s1qd3x1b	262	19	ablation	ablation	NN
cord-252230-s1qd3x1b	262	20	of	of	IN
cord-252230-s1qd3x1b	262	21	LAP	lap	NN
cord-252230-s1qd3x1b	262	22	-	-	HYPH
cord-252230-s1qd3x1b	262	23	specific	specific	JJ
cord-252230-s1qd3x1b	262	24	ATGs	atg	NNS
cord-252230-s1qd3x1b	262	25	in	in	IN
cord-252230-s1qd3x1b	262	26	phagocytic	phagocytic	JJ
cord-252230-s1qd3x1b	262	27	cells	cell	NNS
cord-252230-s1qd3x1b	262	28	results	result	NNS
cord-252230-s1qd3x1b	262	29	in	in	IN
cord-252230-s1qd3x1b	262	30	inefficient	inefficient	JJ
cord-252230-s1qd3x1b	262	31	clearance	clearance	NN
cord-252230-s1qd3x1b	262	32	of	of	IN
cord-252230-s1qd3x1b	262	33	dead	dead	JJ
cord-252230-s1qd3x1b	262	34	cells	cell	NNS
cord-252230-s1qd3x1b	262	35	and	and	CC
cord-252230-s1qd3x1b	262	36	their	-PRON-	PRP$
cord-252230-s1qd3x1b	262	37	immunogenic	immunogenic	JJ
cord-252230-s1qd3x1b	262	38	contents	content	NNS
cord-252230-s1qd3x1b	262	39	,	,	,
cord-252230-s1qd3x1b	262	40	leading	lead	VBG
cord-252230-s1qd3x1b	262	41	to	to	IN
cord-252230-s1qd3x1b	262	42	a	a	DT
cord-252230-s1qd3x1b	262	43	SLE	SLE	NNP
cord-252230-s1qd3x1b	262	44	-	-	HYPH
cord-252230-s1qd3x1b	262	45	like	like	JJ
cord-252230-s1qd3x1b	262	46	disease	disease	NN
cord-252230-s1qd3x1b	262	47	in	in	IN
cord-252230-s1qd3x1b	262	48	mice	mouse	NNS
cord-252230-s1qd3x1b	263	1	(	(	-LRB-
cord-252230-s1qd3x1b	263	2	Martinez	Martinez	NNP
cord-252230-s1qd3x1b	263	3	et	et	NNP
cord-252230-s1qd3x1b	263	4	al	al	NNP
cord-252230-s1qd3x1b	263	5	.	.	NNP
cord-252230-s1qd3x1b	263	6	,	,	,
cord-252230-s1qd3x1b	263	7	2016	2016	CD
cord-252230-s1qd3x1b	263	8	)	)	-RRB-
cord-252230-s1qd3x1b	263	9	.	.	.
cord-252230-s1qd3x1b	264	1	Thus	thus	RB
cord-252230-s1qd3x1b	264	2	,	,	,
cord-252230-s1qd3x1b	264	3	it	-PRON-	PRP
cord-252230-s1qd3x1b	264	4	is	be	VBZ
cord-252230-s1qd3x1b	264	5	possible	possible	JJ
cord-252230-s1qd3x1b	264	6	that	that	IN
cord-252230-s1qd3x1b	264	7	inhibiting	inhibit	VBG
cord-252230-s1qd3x1b	264	8	autophagy	autophagy	NN
cord-252230-s1qd3x1b	264	9	may	may	MD
cord-252230-s1qd3x1b	264	10	ameliorate	ameliorate	VB
cord-252230-s1qd3x1b	264	11	,	,	,
cord-252230-s1qd3x1b	264	12	whereas	whereas	IN
cord-252230-s1qd3x1b	264	13	inhibiting	inhibit	VBG
cord-252230-s1qd3x1b	264	14	LAP	lap	NN
cord-252230-s1qd3x1b	264	15	may	may	MD
cord-252230-s1qd3x1b	264	16	exacerbate	exacerbate	VB
cord-252230-s1qd3x1b	264	17	disease	disease	NN
cord-252230-s1qd3x1b	264	18	.	.	.
cord-252230-s1qd3x1b	265	1	Developing	develop	VBG
cord-252230-s1qd3x1b	265	2	drugs	drug	NNS
cord-252230-s1qd3x1b	265	3	that	that	WDT
cord-252230-s1qd3x1b	265	4	can	can	MD
cord-252230-s1qd3x1b	265	5	exclusively	exclusively	RB
cord-252230-s1qd3x1b	265	6	target	target	VB
cord-252230-s1qd3x1b	265	7	classic	classic	JJ
cord-252230-s1qd3x1b	265	8	autophagy	autophagy	NN
cord-252230-s1qd3x1b	265	9	without	without	IN
cord-252230-s1qd3x1b	265	10	effecting	effect	VBG
cord-252230-s1qd3x1b	265	11	autophagy	autophagy	NN
cord-252230-s1qd3x1b	265	12	-	-	HYPH
cord-252230-s1qd3x1b	265	13	related	relate	VBN
cord-252230-s1qd3x1b	265	14	processes	process	NNS
cord-252230-s1qd3x1b	265	15	,	,	,
cord-252230-s1qd3x1b	265	16	or	or	CC
cord-252230-s1qd3x1b	265	17	vice	vice	NN
cord-252230-s1qd3x1b	265	18	versa	versa	RB
cord-252230-s1qd3x1b	265	19	,	,	,
cord-252230-s1qd3x1b	265	20	may	may	MD
cord-252230-s1qd3x1b	265	21	be	be	VB
cord-252230-s1qd3x1b	265	22	necessary	necessary	JJ
cord-252230-s1qd3x1b	265	23	to	to	TO
cord-252230-s1qd3x1b	265	24	treat	treat	VB
cord-252230-s1qd3x1b	265	25	certain	certain	JJ
cord-252230-s1qd3x1b	265	26	disorders	disorder	NNS
cord-252230-s1qd3x1b	265	27	.	.	.
cord-252230-s1qd3x1b	266	1	Overall	overall	RB
cord-252230-s1qd3x1b	266	2	,	,	,
cord-252230-s1qd3x1b	266	3	these	these	DT
cord-252230-s1qd3x1b	266	4	studies	study	NNS
cord-252230-s1qd3x1b	266	5	illustrate	illustrate	VBP
cord-252230-s1qd3x1b	266	6	the	the	DT
cord-252230-s1qd3x1b	266	7	wide	wide	JJ
cord-252230-s1qd3x1b	266	8	array	array	NN
cord-252230-s1qd3x1b	266	9	of	of	IN
cord-252230-s1qd3x1b	266	10	nonautophagic	nonautophagic	JJ
cord-252230-s1qd3x1b	266	11	functions	function	NNS
cord-252230-s1qd3x1b	266	12	mediated	mediate	VBN
cord-252230-s1qd3x1b	266	13	by	by	IN
cord-252230-s1qd3x1b	266	14	the	the	DT
cord-252230-s1qd3x1b	266	15	ATG	ATG	NNP
cord-252230-s1qd3x1b	266	16	machinery	machinery	NN
cord-252230-s1qd3x1b	266	17	.	.	.
cord-252230-s1qd3x1b	267	1	These	these	DT
cord-252230-s1qd3x1b	267	2	diverse	diverse	JJ
cord-252230-s1qd3x1b	267	3	functions	function	NNS
cord-252230-s1qd3x1b	267	4	deepen	deepen	VBP
cord-252230-s1qd3x1b	267	5	our	-PRON-	PRP$
cord-252230-s1qd3x1b	267	6	understanding	understanding	NN
cord-252230-s1qd3x1b	267	7	of	of	IN
cord-252230-s1qd3x1b	267	8	ATGs	atg	NNS
cord-252230-s1qd3x1b	267	9	in	in	IN
cord-252230-s1qd3x1b	267	10	enacting	enact	VBG
cord-252230-s1qd3x1b	267	11	cellautonomous	cellautonomous	JJ
cord-252230-s1qd3x1b	267	12	and	and	CC
cord-252230-s1qd3x1b	267	13	non	non	JJ
cord-252230-s1qd3x1b	267	14	-	-	JJ
cord-252230-s1qd3x1b	267	15	cell	cell	JJ
cord-252230-s1qd3x1b	267	16	-	-	HYPH
cord-252230-s1qd3x1b	267	17	autonomous	autonomous	JJ
cord-252230-s1qd3x1b	267	18	biological	biological	JJ
cord-252230-s1qd3x1b	267	19	functions	function	NNS
cord-252230-s1qd3x1b	267	20	beyond	beyond	IN
cord-252230-s1qd3x1b	267	21	self	self	NN
cord-252230-s1qd3x1b	267	22	-	-	HYPH
cord-252230-s1qd3x1b	267	23	eating	eat	VBG
cord-252230-s1qd3x1b	267	24	in	in	IN
cord-252230-s1qd3x1b	267	25	both	both	CC
cord-252230-s1qd3x1b	267	26	normal	normal	JJ
cord-252230-s1qd3x1b	267	27	and	and	CC
cord-252230-s1qd3x1b	267	28	disease	disease	NN
cord-252230-s1qd3x1b	267	29	states	state	NNS
cord-252230-s1qd3x1b	267	30	.	.	.
cord-252230-s1qd3x1b	268	1	They	-PRON-	PRP
cord-252230-s1qd3x1b	268	2	also	also	RB
cord-252230-s1qd3x1b	268	3	broach	broach	VBP
cord-252230-s1qd3x1b	268	4	the	the	DT
cord-252230-s1qd3x1b	268	5	importance	importance	NN
cord-252230-s1qd3x1b	268	6	of	of	IN
cord-252230-s1qd3x1b	268	7	revisiting	revisit	VBG
cord-252230-s1qd3x1b	268	8	phenotypes	phenotype	NNS
cord-252230-s1qd3x1b	268	9	and	and	CC
cord-252230-s1qd3x1b	268	10	functions	function	NNS
cord-252230-s1qd3x1b	268	11	,	,	,
cord-252230-s1qd3x1b	268	12	both	both	DT
cord-252230-s1qd3x1b	268	13	in	in	IN
cord-252230-s1qd3x1b	268	14	vitro	vitro	FW
cord-252230-s1qd3x1b	268	15	and	and	CC
cord-252230-s1qd3x1b	268	16	in	in	IN
cord-252230-s1qd3x1b	268	17	vivo	vivo	NN
cord-252230-s1qd3x1b	268	18	,	,	,
cord-252230-s1qd3x1b	268	19	that	that	DT
cord-252230-s1qd3x1b	268	20	to	to	IN
cord-252230-s1qd3x1b	268	21	date	date	NN
cord-252230-s1qd3x1b	268	22	have	have	VBP
cord-252230-s1qd3x1b	268	23	been	be	VBN
cord-252230-s1qd3x1b	268	24	attributed	attribute	VBN
cord-252230-s1qd3x1b	268	25	to	to	IN
cord-252230-s1qd3x1b	268	26	classic	classic	JJ
cord-252230-s1qd3x1b	268	27	autophagy	autophagy	NN
cord-252230-s1qd3x1b	268	28	based	base	VBN
cord-252230-s1qd3x1b	268	29	on	on	IN
cord-252230-s1qd3x1b	268	30	the	the	DT
cord-252230-s1qd3x1b	268	31	genetic	genetic	JJ
cord-252230-s1qd3x1b	268	32	analysis	analysis	NN
cord-252230-s1qd3x1b	268	33	of	of	IN
cord-252230-s1qd3x1b	268	34	a	a	DT
cord-252230-s1qd3x1b	268	35	single	single	JJ
cord-252230-s1qd3x1b	268	36	individual	individual	JJ
cord-252230-s1qd3x1b	268	37	ATG	ATG	NNP
cord-252230-s1qd3x1b	268	38	.	.	.
cord-252230-s1qd3x1b	269	1	Going	go	VBG
cord-252230-s1qd3x1b	269	2	forward	forward	RB
cord-252230-s1qd3x1b	269	3	,	,	,
cord-252230-s1qd3x1b	269	4	it	-PRON-	PRP
cord-252230-s1qd3x1b	269	5	will	will	MD
cord-252230-s1qd3x1b	269	6	be	be	VB
cord-252230-s1qd3x1b	269	7	critical	critical	JJ
cord-252230-s1qd3x1b	269	8	for	for	IN
cord-252230-s1qd3x1b	269	9	future	future	JJ
cord-252230-s1qd3x1b	269	10	researchers	researcher	NNS
cord-252230-s1qd3x1b	269	11	to	to	TO
cord-252230-s1qd3x1b	269	12	keep	keep	VB
cord-252230-s1qd3x1b	269	13	in	in	IN
cord-252230-s1qd3x1b	269	14	mind	mind	NN
cord-252230-s1qd3x1b	269	15	alternative	alternative	JJ
cord-252230-s1qd3x1b	269	16	pathways	pathway	NNS
cord-252230-s1qd3x1b	269	17	,	,	,
cord-252230-s1qd3x1b	269	18	not	not	RB
cord-252230-s1qd3x1b	269	19	just	just	RB
cord-252230-s1qd3x1b	269	20	autophagy	autophagy	NN
cord-252230-s1qd3x1b	269	21	,	,	,
cord-252230-s1qd3x1b	269	22	upon	upon	IN
cord-252230-s1qd3x1b	269	23	discovering	discover	VBG
cord-252230-s1qd3x1b	269	24	new	new	JJ
cord-252230-s1qd3x1b	269	25	ATG	ATG	NNP
cord-252230-s1qd3x1b	269	26	-	-	HYPH
cord-252230-s1qd3x1b	269	27	dependent	dependent	JJ
cord-252230-s1qd3x1b	269	28	phenotypes	phenotype	NNS
cord-252230-s1qd3x1b	269	29	.	.	.
cord-252230-s1qd3x1b	270	1	Importantly	importantly	RB
cord-252230-s1qd3x1b	270	2	,	,	,
cord-252230-s1qd3x1b	270	3	in	in	IN
cord-252230-s1qd3x1b	270	4	future	future	JJ
cord-252230-s1qd3x1b	270	5	studies	study	NNS
cord-252230-s1qd3x1b	270	6	to	to	TO
cord-252230-s1qd3x1b	270	7	delineate	delineate	VB
cord-252230-s1qd3x1b	270	8	how	how	WRB
cord-252230-s1qd3x1b	270	9	autophagy	autophagy	NN
cord-252230-s1qd3x1b	270	10	influences	influence	NNS
cord-252230-s1qd3x1b	270	11	both	both	CC
cord-252230-s1qd3x1b	270	12	normal	normal	JJ
cord-252230-s1qd3x1b	270	13	physiology	physiology	NN
cord-252230-s1qd3x1b	270	14	and	and	CC
cord-252230-s1qd3x1b	270	15	disease	disease	NN
cord-252230-s1qd3x1b	270	16	,	,	,
cord-252230-s1qd3x1b	270	17	it	-PRON-	PRP
cord-252230-s1qd3x1b	270	18	will	will	MD
cord-252230-s1qd3x1b	270	19	be	be	VB
cord-252230-s1qd3x1b	270	20	incumbent	incumbent	JJ
cord-252230-s1qd3x1b	270	21	on	on	IN
cord-252230-s1qd3x1b	270	22	researchers	researcher	NNS
cord-252230-s1qd3x1b	270	23	to	to	TO
cord-252230-s1qd3x1b	270	24	interrogate	interrogate	VB
cord-252230-s1qd3x1b	270	25	multiple	multiple	JJ
cord-252230-s1qd3x1b	270	26	ATGs	atg	NNS
cord-252230-s1qd3x1b	270	27	controlling	control	VBG
cord-252230-s1qd3x1b	270	28	distinct	distinct	JJ
cord-252230-s1qd3x1b	270	29	elements	element	NNS
cord-252230-s1qd3x1b	270	30	of	of	IN
cord-252230-s1qd3x1b	270	31	the	the	DT
cord-252230-s1qd3x1b	270	32	autophagy	autophagy	NN
cord-252230-s1qd3x1b	270	33	trafficking	traffic	VBG
cord-252230-s1qd3x1b	270	34	pathway	pathway	NN
cord-252230-s1qd3x1b	270	35	to	to	TO
cord-252230-s1qd3x1b	270	36	definitively	definitively	RB
cord-252230-s1qd3x1b	270	37	attribute	attribute	VB
cord-252230-s1qd3x1b	270	38	a	a	DT
cord-252230-s1qd3x1b	270	39	role	role	NN
cord-252230-s1qd3x1b	270	40	for	for	IN
cord-252230-s1qd3x1b	270	41	classic	classic	JJ
cord-252230-s1qd3x1b	270	42	autophagy	autophagy	NN
cord-252230-s1qd3x1b	270	43	on	on	IN
cord-252230-s1qd3x1b	270	44	cell	cell	NN
cord-252230-s1qd3x1b	270	45	fate	fate	NN
cord-252230-s1qd3x1b	270	46	and	and	CC
cord-252230-s1qd3x1b	270	47	function	function	NN
cord-252230-s1qd3x1b	270	48	.	.	.
cord-252230-s1qd3x1b	271	1	In	in	IN
cord-252230-s1qd3x1b	271	2	a	a	DT
cord-252230-s1qd3x1b	271	3	similar	similar	JJ
cord-252230-s1qd3x1b	271	4	vein	vein	NN
cord-252230-s1qd3x1b	271	5	,	,	,
cord-252230-s1qd3x1b	271	6	as	as	IN
cord-252230-s1qd3x1b	271	7	we	-PRON-	PRP
cord-252230-s1qd3x1b	271	8	develop	develop	VBP
cord-252230-s1qd3x1b	271	9	more	more	RBR
cord-252230-s1qd3x1b	271	10	precise	precise	JJ
cord-252230-s1qd3x1b	271	11	methods	method	NNS
cord-252230-s1qd3x1b	271	12	to	to	TO
cord-252230-s1qd3x1b	271	13	therapeutically	therapeutically	RB
cord-252230-s1qd3x1b	271	14	target	target	VB
cord-252230-s1qd3x1b	271	15	specific	specific	JJ
cord-252230-s1qd3x1b	271	16	autophagy	autophagy	NN
cord-252230-s1qd3x1b	271	17	machinery	machinery	NN
cord-252230-s1qd3x1b	271	18	components	component	NNS
cord-252230-s1qd3x1b	271	19	,	,	,
cord-252230-s1qd3x1b	271	20	the	the	DT
cord-252230-s1qd3x1b	271	21	role	role	NN
cord-252230-s1qd3x1b	271	22	of	of	IN
cord-252230-s1qd3x1b	271	23	alternative	alternative	JJ
cord-252230-s1qd3x1b	271	24	autophagy	autophagy	NN
cord-252230-s1qd3x1b	271	25	-	-	HYPH
cord-252230-s1qd3x1b	271	26	related	relate	VBN
cord-252230-s1qd3x1b	271	27	processes	process	NNS
cord-252230-s1qd3x1b	271	28	and	and	CC
cord-252230-s1qd3x1b	271	29	signaling	signal	VBG
cord-252230-s1qd3x1b	271	30	pathways	pathway	NNS
cord-252230-s1qd3x1b	271	31	merit	merit	VBP
cord-252230-s1qd3x1b	271	32	thoughtful	thoughtful	JJ
cord-252230-s1qd3x1b	271	33	and	and	CC
cord-252230-s1qd3x1b	271	34	rigorous	rigorous	JJ
cord-252230-s1qd3x1b	271	35	consideration	consideration	NN
cord-252230-s1qd3x1b	271	36	.	.	.
cord-252230-s1qd3x1b	272	1	Paneth	Paneth	NNP
cord-252230-s1qd3x1b	272	2	cells	cell	NNS
cord-252230-s1qd3x1b	272	3	as	as	IN
cord-252230-s1qd3x1b	272	4	a	a	DT
cord-252230-s1qd3x1b	272	5	site	site	NN
cord-252230-s1qd3x1b	272	6	of	of	IN
cord-252230-s1qd3x1b	272	7	origin	origin	NN
cord-252230-s1qd3x1b	272	8	for	for	IN
cord-252230-s1qd3x1b	272	9	intestinal	intestinal	JJ
cord-252230-s1qd3x1b	272	10	inflammation	inflammation	NN
cord-252230-s1qd3x1b	272	11	Pancreatic	pancreatic	JJ
cord-252230-s1qd3x1b	272	12	acinar	acinar	JJ
cord-252230-s1qd3x1b	272	13	cell	cell	NN
cord-252230-s1qd3x1b	272	14	-	-	HYPH
cord-252230-s1qd3x1b	272	15	specific	specific	JJ
cord-252230-s1qd3x1b	272	16	autophagy	autophagy	NN
cord-252230-s1qd3x1b	272	17	disruption	disruption	NN
cord-252230-s1qd3x1b	272	18	reduces	reduce	VBZ
cord-252230-s1qd3x1b	272	19	coxsackievirus	coxsackievirus	NNP
cord-252230-s1qd3x1b	272	20	replication	replication	NN
cord-252230-s1qd3x1b	272	21	and	and	CC
cord-252230-s1qd3x1b	272	22	pathogenesis	pathogenesis	NN
cord-252230-s1qd3x1b	272	23	in	in	IN
cord-252230-s1qd3x1b	272	24	vivo	vivo	NN
cord-252230-s1qd3x1b	273	1	Tregs	treg	NNS
cord-252230-s1qd3x1b	273	2	restrain	restrain	VBP
cord-252230-s1qd3x1b	273	3	dendritic	dendritic	JJ
cord-252230-s1qd3x1b	273	4	cell	cell	NN
cord-252230-s1qd3x1b	273	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	273	6	to	to	TO
cord-252230-s1qd3x1b	273	7	ameliorate	ameliorate	VB
cord-252230-s1qd3x1b	273	8	autoimmunity	autoimmunity	IN
cord-252230-s1qd3x1b	273	9	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	273	10	is	be	VBZ
cord-252230-s1qd3x1b	273	11	dispensable	dispensable	JJ
cord-252230-s1qd3x1b	273	12	for	for	IN
cord-252230-s1qd3x1b	273	13	B	b	NN
cord-252230-s1qd3x1b	273	14	-	-	HYPH
cord-252230-s1qd3x1b	273	15	cell	cell	NN
cord-252230-s1qd3x1b	273	16	development	development	NN
cord-252230-s1qd3x1b	273	17	but	but	CC
cord-252230-s1qd3x1b	273	18	essential	essential	JJ
cord-252230-s1qd3x1b	273	19	for	for	IN
cord-252230-s1qd3x1b	273	20	humoral	humoral	JJ
cord-252230-s1qd3x1b	273	21	autoimmune	autoimmune	JJ
cord-252230-s1qd3x1b	273	22	responses	response	NNS
cord-252230-s1qd3x1b	274	1	A	a	DT
cord-252230-s1qd3x1b	274	2	LC3-interacting	lc3-interacte	VBG
cord-252230-s1qd3x1b	274	3	motif	motif	NN
cord-252230-s1qd3x1b	274	4	in	in	IN
cord-252230-s1qd3x1b	274	5	the	the	DT
cord-252230-s1qd3x1b	274	6	influenza	influenza	NN
cord-252230-s1qd3x1b	274	7	A	a	DT
cord-252230-s1qd3x1b	274	8	virus	virus	NN
cord-252230-s1qd3x1b	274	9	M2	m2	NN
cord-252230-s1qd3x1b	274	10	protein	protein	NN
cord-252230-s1qd3x1b	274	11	is	be	VBZ
cord-252230-s1qd3x1b	274	12	required	require	VBN
cord-252230-s1qd3x1b	274	13	to	to	TO
cord-252230-s1qd3x1b	274	14	subvert	subvert	VB
cord-252230-s1qd3x1b	274	15	autophagy	autophagy	NN
cord-252230-s1qd3x1b	274	16	and	and	CC
cord-252230-s1qd3x1b	274	17	maintain	maintain	VB
cord-252230-s1qd3x1b	274	18	virion	virion	NN
cord-252230-s1qd3x1b	274	19	stability	stability	NN
cord-252230-s1qd3x1b	274	20	Paneth	Paneth	NNP
cord-252230-s1qd3x1b	274	21	cells	cell	VBZ
cord-252230-s1qd3x1b	274	22	secrete	secrete	VBP
cord-252230-s1qd3x1b	274	23	lysozyme	lysozyme	NNS
cord-252230-s1qd3x1b	274	24	via	via	IN
cord-252230-s1qd3x1b	274	25	secretory	secretory	JJ
cord-252230-s1qd3x1b	274	26	autophagy	autophagy	NN
cord-252230-s1qd3x1b	274	27	during	during	IN
cord-252230-s1qd3x1b	274	28	bacterial	bacterial	JJ
cord-252230-s1qd3x1b	274	29	infection	infection	NN
cord-252230-s1qd3x1b	274	30	of	of	IN
cord-252230-s1qd3x1b	274	31	the	the	DT
cord-252230-s1qd3x1b	274	32	intestine	intestine	NN
cord-252230-s1qd3x1b	274	33	Intestinal	intestinal	JJ
cord-252230-s1qd3x1b	274	34	epithelial	epithelial	JJ
cord-252230-s1qd3x1b	274	35	autophagy	autophagy	NN
cord-252230-s1qd3x1b	274	36	is	be	VBZ
cord-252230-s1qd3x1b	274	37	essential	essential	JJ
cord-252230-s1qd3x1b	274	38	for	for	IN
cord-252230-s1qd3x1b	274	39	host	host	NN
cord-252230-s1qd3x1b	274	40	defense	defense	NN
cord-252230-s1qd3x1b	274	41	against	against	IN
cord-252230-s1qd3x1b	274	42	invasive	invasive	JJ
cord-252230-s1qd3x1b	274	43	bacteria	bacteria	NNS
cord-252230-s1qd3x1b	274	44	Viral	viral	JJ
cord-252230-s1qd3x1b	274	45	replication	replication	NN
cord-252230-s1qd3x1b	274	46	complexes	complex	NNS
cord-252230-s1qd3x1b	274	47	are	be	VBP
cord-252230-s1qd3x1b	274	48	targeted	target	VBN
cord-252230-s1qd3x1b	274	49	by	by	IN
cord-252230-s1qd3x1b	274	50	LC3-guided	LC3-guided	NNP
cord-252230-s1qd3x1b	274	51	interferon	interferon	NN
cord-252230-s1qd3x1b	274	52	-	-	HYPH
cord-252230-s1qd3x1b	274	53	inducible	inducible	JJ
cord-252230-s1qd3x1b	274	54	GTPases	gtpase	NNS
cord-252230-s1qd3x1b	275	1	Nonlytic	nonlytic	JJ
cord-252230-s1qd3x1b	275	2	viral	viral	JJ
cord-252230-s1qd3x1b	275	3	spread	spread	NN
cord-252230-s1qd3x1b	275	4	enhanced	enhance	VBN
cord-252230-s1qd3x1b	275	5	by	by	IN
cord-252230-s1qd3x1b	275	6	autophagy	autophagy	NN
cord-252230-s1qd3x1b	275	7	components	component	NNS
cord-252230-s1qd3x1b	276	1	The	the	DT
cord-252230-s1qd3x1b	276	2	T300A	T300A	NNP
cord-252230-s1qd3x1b	276	3	Crohn	Crohn	NNP
cord-252230-s1qd3x1b	276	4	's	's	POS
cord-252230-s1qd3x1b	276	5	disease	disease	NN
cord-252230-s1qd3x1b	276	6	risk	risk	NN
cord-252230-s1qd3x1b	276	7	polymorphism	polymorphism	NN
cord-252230-s1qd3x1b	276	8	impairs	impair	VBZ
cord-252230-s1qd3x1b	276	9	function	function	NN
cord-252230-s1qd3x1b	276	10	of	of	IN
cord-252230-s1qd3x1b	276	11	the	the	DT
cord-252230-s1qd3x1b	276	12	WD40	WD40	NNP
cord-252230-s1qd3x1b	276	13	domain	domain	NN
cord-252230-s1qd3x1b	276	14	of	of	IN
cord-252230-s1qd3x1b	276	15	ATG16L1	atg16l1	JJ
cord-252230-s1qd3x1b	276	16	Exocytosis	Exocytosis	NNP
cord-252230-s1qd3x1b	276	17	of	of	IN
cord-252230-s1qd3x1b	276	18	Varicella	Varicella	NNP
cord-252230-s1qd3x1b	276	19	-	-	HYPH
cord-252230-s1qd3x1b	276	20	Zoster	Zoster	NNP
cord-252230-s1qd3x1b	276	21	Virus	Virus	NNP
cord-252230-s1qd3x1b	276	22	Virions	Virions	NNP
cord-252230-s1qd3x1b	276	23	Involves	involve	VBZ
cord-252230-s1qd3x1b	276	24	a	a	DT
cord-252230-s1qd3x1b	276	25	Convergence	Convergence	NNP
cord-252230-s1qd3x1b	276	26	of	of	IN
cord-252230-s1qd3x1b	276	27	Endosomal	Endosomal	NNP
cord-252230-s1qd3x1b	276	28	and	and	CC
cord-252230-s1qd3x1b	276	29	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	276	30	Pathways	Pathways	NNPS
cord-252230-s1qd3x1b	276	31	Crosstalk	Crosstalk	NNP
cord-252230-s1qd3x1b	276	32	between	between	IN
cord-252230-s1qd3x1b	276	33	autophagy	autophagy	NN
cord-252230-s1qd3x1b	276	34	and	and	CC
cord-252230-s1qd3x1b	276	35	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	276	36	signalling	signal	VBG
cord-252230-s1qd3x1b	276	37	pathways	pathway	NNS
cord-252230-s1qd3x1b	276	38	:	:	:
cord-252230-s1qd3x1b	276	39	balancing	balance	VBG
cord-252230-s1qd3x1b	276	40	defence	defence	NN
cord-252230-s1qd3x1b	276	41	and	and	CC
cord-252230-s1qd3x1b	276	42	homeostasis	homeostasis	NN
cord-252230-s1qd3x1b	276	43	A	a	DT
cord-252230-s1qd3x1b	276	44	key	key	JJ
cord-252230-s1qd3x1b	276	45	role	role	NN
cord-252230-s1qd3x1b	276	46	for	for	IN
cord-252230-s1qd3x1b	276	47	autophagy	autophagy	NN
cord-252230-s1qd3x1b	276	48	and	and	CC
cord-252230-s1qd3x1b	276	49	the	the	DT
cord-252230-s1qd3x1b	276	50	autophagy	autophagy	NN
cord-252230-s1qd3x1b	276	51	gene	gene	NN
cord-252230-s1qd3x1b	277	1	Atg16l1	Atg16l1	NNP
cord-252230-s1qd3x1b	277	2	in	in	IN
cord-252230-s1qd3x1b	277	3	mouse	mouse	NN
cord-252230-s1qd3x1b	277	4	and	and	CC
cord-252230-s1qd3x1b	277	5	human	human	JJ
cord-252230-s1qd3x1b	277	6	intestinal	intestinal	JJ
cord-252230-s1qd3x1b	277	7	Paneth	Paneth	NNP
cord-252230-s1qd3x1b	277	8	cells	cell	NNS
cord-252230-s1qd3x1b	277	9	Virusplus	Virusplus	NNP
cord-252230-s1qd3x1b	277	10	-	-	HYPH
cord-252230-s1qd3x1b	277	11	susceptibility	susceptibility	NN
cord-252230-s1qd3x1b	277	12	gene	gene	NN
cord-252230-s1qd3x1b	277	13	interaction	interaction	NN
cord-252230-s1qd3x1b	277	14	determines	determine	VBZ
cord-252230-s1qd3x1b	277	15	Crohn	Crohn	NNP
cord-252230-s1qd3x1b	277	16	's	's	POS
cord-252230-s1qd3x1b	277	17	disease	disease	NN
cord-252230-s1qd3x1b	277	18	gene	gene	NN
cord-252230-s1qd3x1b	277	19	Atg16L1	Atg16L1	NNP
cord-252230-s1qd3x1b	277	20	phenotypes	phenotype	NNS
cord-252230-s1qd3x1b	277	21	in	in	IN
cord-252230-s1qd3x1b	277	22	intestine	intestine	NN
cord-252230-s1qd3x1b	277	23	Essential	essential	JJ
cord-252230-s1qd3x1b	277	24	role	role	NN
cord-252230-s1qd3x1b	277	25	for	for	IN
cord-252230-s1qd3x1b	277	26	autophagy	autophagy	NN
cord-252230-s1qd3x1b	277	27	in	in	IN
cord-252230-s1qd3x1b	277	28	the	the	DT
cord-252230-s1qd3x1b	277	29	maintenance	maintenance	NN
cord-252230-s1qd3x1b	277	30	of	of	IN
cord-252230-s1qd3x1b	277	31	immunological	immunological	JJ
cord-252230-s1qd3x1b	277	32	memory	memory	NN
cord-252230-s1qd3x1b	277	33	against	against	IN
cord-252230-s1qd3x1b	277	34	influenza	influenza	NN
cord-252230-s1qd3x1b	277	35	infection	infection	NN
cord-252230-s1qd3x1b	277	36	Requirement	Requirement	NNP
cord-252230-s1qd3x1b	277	37	for	for	IN
cord-252230-s1qd3x1b	277	38	autophagy	autophagy	NN
cord-252230-s1qd3x1b	277	39	in	in	IN
cord-252230-s1qd3x1b	277	40	the	the	DT
cord-252230-s1qd3x1b	277	41	long	long	JJ
cord-252230-s1qd3x1b	277	42	-	-	HYPH
cord-252230-s1qd3x1b	277	43	term	term	NN
cord-252230-s1qd3x1b	277	44	persistence	persistence	NN
cord-252230-s1qd3x1b	277	45	but	but	CC
cord-252230-s1qd3x1b	277	46	not	not	RB
cord-252230-s1qd3x1b	277	47	initial	initial	JJ
cord-252230-s1qd3x1b	277	48	formation	formation	NN
cord-252230-s1qd3x1b	277	49	of	of	IN
cord-252230-s1qd3x1b	277	50	memory	memory	NN
cord-252230-s1qd3x1b	277	51	B	b	NN
cord-252230-s1qd3x1b	277	52	cells	cell	NNS
cord-252230-s1qd3x1b	277	53	Regulation	regulation	NN
cord-252230-s1qd3x1b	277	54	and	and	CC
cord-252230-s1qd3x1b	277	55	function	function	NN
cord-252230-s1qd3x1b	277	56	of	of	IN
cord-252230-s1qd3x1b	277	57	the	the	DT
cord-252230-s1qd3x1b	277	58	cGAS	cgas	JJ
cord-252230-s1qd3x1b	277	59	-	-	HYPH
cord-252230-s1qd3x1b	277	60	STI	STI	NNP
cord-252230-s1qd3x1b	277	61	NG	NG	NNP
cord-252230-s1qd3x1b	277	62	pathway	pathway	NN
cord-252230-s1qd3x1b	277	63	of	of	IN
cord-252230-s1qd3x1b	277	64	cytosolic	cytosolic	JJ
cord-252230-s1qd3x1b	277	65	DNA	dna	NN
cord-252230-s1qd3x1b	277	66	sensing	sensing	NN
cord-252230-s1qd3x1b	277	67	Phosphatidylserine	phosphatidylserine	NN
cord-252230-s1qd3x1b	277	68	vesicles	vesicle	NNS
cord-252230-s1qd3x1b	277	69	enable	enable	VBP
cord-252230-s1qd3x1b	277	70	efficient	efficient	JJ
cord-252230-s1qd3x1b	277	71	en	en	IN
cord-252230-s1qd3x1b	277	72	bloc	bloc	NNP
cord-252230-s1qd3x1b	277	73	transmission	transmission	NN
cord-252230-s1qd3x1b	277	74	of	of	IN
cord-252230-s1qd3x1b	277	75	enteroviruses	enteroviruses	NNP
cord-252230-s1qd3x1b	277	76	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	277	77	in	in	IN
cord-252230-s1qd3x1b	277	78	human	human	JJ
cord-252230-s1qd3x1b	277	79	health	health	NN
cord-252230-s1qd3x1b	277	80	and	and	CC
cord-252230-s1qd3x1b	277	81	disease	disease	NN
cord-252230-s1qd3x1b	278	1	The	the	DT
cord-252230-s1qd3x1b	278	2	parasitophorous	parasitophorous	JJ
cord-252230-s1qd3x1b	278	3	vacuole	vacuole	NN
cord-252230-s1qd3x1b	278	4	membrane	membrane	NN
cord-252230-s1qd3x1b	278	5	of	of	IN
cord-252230-s1qd3x1b	278	6	Toxoplasma	toxoplasma	JJ
cord-252230-s1qd3x1b	278	7	gondii	gondii	NN
cord-252230-s1qd3x1b	278	8	is	be	VBZ
cord-252230-s1qd3x1b	278	9	targeted	target	VBN
cord-252230-s1qd3x1b	278	10	for	for	IN
cord-252230-s1qd3x1b	278	11	disruption	disruption	NN
cord-252230-s1qd3x1b	278	12	by	by	IN
cord-252230-s1qd3x1b	278	13	ubiquitin	ubiquitin	NN
cord-252230-s1qd3x1b	278	14	-	-	HYPH
cord-252230-s1qd3x1b	278	15	like	like	JJ
cord-252230-s1qd3x1b	278	16	conjugation	conjugation	NN
cord-252230-s1qd3x1b	278	17	systems	system	NNS
cord-252230-s1qd3x1b	278	18	of	of	IN
cord-252230-s1qd3x1b	278	19	autophagy	autophagy	NN
cord-252230-s1qd3x1b	278	20	Genemicrobiota	Genemicrobiota	NNP
cord-252230-s1qd3x1b	278	21	interactions	interaction	NNS
cord-252230-s1qd3x1b	278	22	contribute	contribute	VBP
cord-252230-s1qd3x1b	278	23	to	to	IN
cord-252230-s1qd3x1b	278	24	the	the	DT
cord-252230-s1qd3x1b	278	25	pathogenesis	pathogenesis	NN
cord-252230-s1qd3x1b	278	26	of	of	IN
cord-252230-s1qd3x1b	278	27	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	278	28	bowel	bowel	NN
cord-252230-s1qd3x1b	278	29	disease	disease	NN
cord-252230-s1qd3x1b	278	30	Canonical	canonical	JJ
cord-252230-s1qd3x1b	278	31	and	and	CC
cord-252230-s1qd3x1b	278	32	noncanonical	noncanonical	JJ
cord-252230-s1qd3x1b	278	33	autophagy	autophagy	NN
cord-252230-s1qd3x1b	278	34	:	:	:
cord-252230-s1qd3x1b	278	35	variations	variation	NNS
cord-252230-s1qd3x1b	278	36	on	on	IN
cord-252230-s1qd3x1b	278	37	a	a	DT
cord-252230-s1qd3x1b	278	38	common	common	JJ
cord-252230-s1qd3x1b	278	39	theme	theme	NN
cord-252230-s1qd3x1b	278	40	of	of	IN
cord-252230-s1qd3x1b	278	41	self	self	NN
cord-252230-s1qd3x1b	278	42	-	-	HYPH
cord-252230-s1qd3x1b	278	43	eating	eat	VBG
cord-252230-s1qd3x1b	278	44	?	?	.
cord-252230-s1qd3x1b	279	1	Biogenesis	biogenesis	NN
cord-252230-s1qd3x1b	279	2	,	,	,
cord-252230-s1qd3x1b	279	3	secretion	secretion	NN
cord-252230-s1qd3x1b	279	4	,	,	,
cord-252230-s1qd3x1b	279	5	and	and	CC
cord-252230-s1qd3x1b	279	6	intercellular	intercellular	JJ
cord-252230-s1qd3x1b	279	7	interactions	interaction	NNS
cord-252230-s1qd3x1b	279	8	of	of	IN
cord-252230-s1qd3x1b	279	9	exosomes	exosome	NNS
cord-252230-s1qd3x1b	279	10	and	and	CC
cord-252230-s1qd3x1b	279	11	other	other	JJ
cord-252230-s1qd3x1b	279	12	extracellular	extracellular	JJ
cord-252230-s1qd3x1b	279	13	vesicles	vesicle	NNS
cord-252230-s1qd3x1b	280	1	ATG5	ATG5	NNP
cord-252230-s1qd3x1b	280	2	regulates	regulate	VBZ
cord-252230-s1qd3x1b	280	3	plasma	plasma	NN
cord-252230-s1qd3x1b	280	4	cell	cell	NN
cord-252230-s1qd3x1b	280	5	differentiation	differentiation	NN
cord-252230-s1qd3x1b	281	1	Atg16l1	Atg16l1	NNP
cord-252230-s1qd3x1b	281	2	is	be	VBZ
cord-252230-s1qd3x1b	281	3	required	require	VBN
cord-252230-s1qd3x1b	281	4	for	for	IN
cord-252230-s1qd3x1b	281	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	281	6	in	in	IN
cord-252230-s1qd3x1b	281	7	intestinal	intestinal	JJ
cord-252230-s1qd3x1b	281	8	epithelial	epithelial	JJ
cord-252230-s1qd3x1b	281	9	cells	cell	NNS
cord-252230-s1qd3x1b	281	10	and	and	CC
cord-252230-s1qd3x1b	281	11	protection	protection	NN
cord-252230-s1qd3x1b	281	12	of	of	IN
cord-252230-s1qd3x1b	281	13	mice	mouse	NNS
cord-252230-s1qd3x1b	281	14	from	from	IN
cord-252230-s1qd3x1b	281	15	Salmonella	Salmonella	NNP
cord-252230-s1qd3x1b	281	16	infection	infection	NN
cord-252230-s1qd3x1b	281	17	Remodeling	remodeling	NN
cord-252230-s1qd3x1b	281	18	of	of	IN
cord-252230-s1qd3x1b	281	19	secretory	secretory	JJ
cord-252230-s1qd3x1b	281	20	compartments	compartment	NNS
cord-252230-s1qd3x1b	281	21	creates	create	VBZ
cord-252230-s1qd3x1b	281	22	CUPS	cup	NNS
cord-252230-s1qd3x1b	281	23	during	during	IN
cord-252230-s1qd3x1b	281	24	nutrient	nutrient	NN
cord-252230-s1qd3x1b	281	25	starvation	starvation	NN
cord-252230-s1qd3x1b	282	1	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	282	2	promotes	promote	VBZ
cord-252230-s1qd3x1b	282	3	MHC	MHC	NNP
cord-252230-s1qd3x1b	282	4	class	class	NN
cord-252230-s1qd3x1b	282	5	II	II	NNP
cord-252230-s1qd3x1b	282	6	presentation	presentation	NN
cord-252230-s1qd3x1b	282	7	of	of	IN
cord-252230-s1qd3x1b	282	8	peptides	peptide	NNS
cord-252230-s1qd3x1b	282	9	from	from	IN
cord-252230-s1qd3x1b	282	10	intracellular	intracellular	JJ
cord-252230-s1qd3x1b	282	11	source	source	NN
cord-252230-s1qd3x1b	282	12	proteins	protein	NNS
cord-252230-s1qd3x1b	282	13	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	282	14	,	,	,
cord-252230-s1qd3x1b	282	15	immunity	immunity	NN
cord-252230-s1qd3x1b	282	16	,	,	,
cord-252230-s1qd3x1b	282	17	and	and	CC
cord-252230-s1qd3x1b	282	18	microbial	microbial	JJ
cord-252230-s1qd3x1b	282	19	adaptations	adaptation	NNS
cord-252230-s1qd3x1b	283	1	Autophagy	autophagy	JJ
cord-252230-s1qd3x1b	283	2	intersections	intersection	NNS
cord-252230-s1qd3x1b	283	3	with	with	IN
cord-252230-s1qd3x1b	283	4	conventional	conventional	JJ
cord-252230-s1qd3x1b	283	5	and	and	CC
cord-252230-s1qd3x1b	283	6	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	283	7	secretion	secretion	NN
cord-252230-s1qd3x1b	283	8	in	in	IN
cord-252230-s1qd3x1b	283	9	tissue	tissue	NN
cord-252230-s1qd3x1b	283	10	development	development	NN
cord-252230-s1qd3x1b	283	11	,	,	,
cord-252230-s1qd3x1b	283	12	remodeling	remodeling	NN
cord-252230-s1qd3x1b	283	13	and	and	CC
cord-252230-s1qd3x1b	283	14	inflammation	inflammation	NN
cord-252230-s1qd3x1b	284	1	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	284	2	proteins	protein	NNS
cord-252230-s1qd3x1b	284	3	regulate	regulate	VBP
cord-252230-s1qd3x1b	284	4	the	the	DT
cord-252230-s1qd3x1b	284	5	secretory	secretory	JJ
cord-252230-s1qd3x1b	284	6	component	component	NN
cord-252230-s1qd3x1b	284	7	of	of	IN
cord-252230-s1qd3x1b	284	8	osteoclastic	osteoclastic	JJ
cord-252230-s1qd3x1b	284	9	bone	bone	NN
cord-252230-s1qd3x1b	284	10	resorption	resorption	NN
cord-252230-s1qd3x1b	284	11	IKKα	IKKα	NNP
cord-252230-s1qd3x1b	284	12	controls	control	VBZ
cord-252230-s1qd3x1b	284	13	ATG16L1	atg16l1	JJ
cord-252230-s1qd3x1b	284	14	degradation	degradation	NN
cord-252230-s1qd3x1b	284	15	to	to	TO
cord-252230-s1qd3x1b	284	16	prevent	prevent	VB
cord-252230-s1qd3x1b	284	17	ER	ER	NNP
cord-252230-s1qd3x1b	284	18	stress	stress	NN
cord-252230-s1qd3x1b	284	19	during	during	IN
cord-252230-s1qd3x1b	284	20	inflammation	inflammation	NN
cord-252230-s1qd3x1b	285	1	The	the	DT
cord-252230-s1qd3x1b	285	2	matrix	matrix	NN
cord-252230-s1qd3x1b	285	3	protein	protein	NN
cord-252230-s1qd3x1b	285	4	of	of	IN
cord-252230-s1qd3x1b	285	5	human	human	NNP
cord-252230-s1qd3x1b	285	6	parainfluenza	parainfluenza	NNP
cord-252230-s1qd3x1b	285	7	virus	virus	NNP
cord-252230-s1qd3x1b	285	8	type	type	NNP
cord-252230-s1qd3x1b	285	9	3	3	CD
cord-252230-s1qd3x1b	285	10	induces	induce	VBZ
cord-252230-s1qd3x1b	285	11	mitophagy	mitophagy	NN
cord-252230-s1qd3x1b	285	12	that	that	WDT
cord-252230-s1qd3x1b	285	13	suppresses	suppress	VBZ
cord-252230-s1qd3x1b	285	14	interferon	interferon	NN
cord-252230-s1qd3x1b	285	15	responses	response	NNS
cord-252230-s1qd3x1b	285	16	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	285	17	-	-	HYPH
cord-252230-s1qd3x1b	285	18	based	base	VBN
cord-252230-s1qd3x1b	285	19	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	285	20	secretory	secretory	JJ
cord-252230-s1qd3x1b	285	21	pathway	pathway	NN
cord-252230-s1qd3x1b	285	22	for	for	IN
cord-252230-s1qd3x1b	285	23	extracellular	extracellular	JJ
cord-252230-s1qd3x1b	285	24	delivery	delivery	NN
cord-252230-s1qd3x1b	285	25	of	of	IN
cord-252230-s1qd3x1b	285	26	IL-1β	il-1β	DT
cord-252230-s1qd3x1b	285	27	Unconventional	unconventional	JJ
cord-252230-s1qd3x1b	285	28	secretion	secretion	NN
cord-252230-s1qd3x1b	285	29	of	of	IN
cord-252230-s1qd3x1b	285	30	Acb1	Acb1	NNP
cord-252230-s1qd3x1b	285	31	is	be	VBZ
cord-252230-s1qd3x1b	285	32	mediated	mediate	VBN
cord-252230-s1qd3x1b	285	33	by	by	IN
cord-252230-s1qd3x1b	285	34	autophagosomes	autophagosomes	NNP
cord-252230-s1qd3x1b	285	35	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	285	36	machinery	machinery	NN
cord-252230-s1qd3x1b	285	37	mediates	mediate	VBZ
cord-252230-s1qd3x1b	285	38	macroendocytic	macroendocytic	JJ
cord-252230-s1qd3x1b	285	39	processing	processing	NN
cord-252230-s1qd3x1b	285	40	and	and	CC
cord-252230-s1qd3x1b	285	41	entotic	entotic	JJ
cord-252230-s1qd3x1b	285	42	cell	cell	NN
cord-252230-s1qd3x1b	285	43	death	death	NN
cord-252230-s1qd3x1b	285	44	by	by	IN
cord-252230-s1qd3x1b	285	45	targeting	target	VBG
cord-252230-s1qd3x1b	285	46	single	single	JJ
cord-252230-s1qd3x1b	285	47	membranes	membrane	NNS
cord-252230-s1qd3x1b	285	48	Matrix	Matrix	NNP
cord-252230-s1qd3x1b	285	49	protein	protein	NN
cord-252230-s1qd3x1b	285	50	2	2	CD
cord-252230-s1qd3x1b	285	51	of	of	IN
cord-252230-s1qd3x1b	285	52	influenza	influenza	NN
cord-252230-s1qd3x1b	285	53	A	a	DT
cord-252230-s1qd3x1b	285	54	virus	virus	NN
cord-252230-s1qd3x1b	285	55	blocks	block	VBZ
cord-252230-s1qd3x1b	285	56	autophagosome	autophagosome	JJ
cord-252230-s1qd3x1b	285	57	fusion	fusion	NN
cord-252230-s1qd3x1b	285	58	with	with	IN
cord-252230-s1qd3x1b	285	59	lysosomes	lysosomes	JJ
cord-252230-s1qd3x1b	285	60	Rescue	Rescue	NNP
cord-252230-s1qd3x1b	285	61	of	of	IN
cord-252230-s1qd3x1b	285	62	ΔF508-CFTR	ΔF508-CFTR	VBG
cord-252230-s1qd3x1b	285	63	trafficking	trafficking	NN
cord-252230-s1qd3x1b	285	64	via	via	IN
cord-252230-s1qd3x1b	285	65	a	a	DT
cord-252230-s1qd3x1b	285	66	GRA	GRA	NNP
cord-252230-s1qd3x1b	285	67	SP	SP	NNP
cord-252230-s1qd3x1b	285	68	-	-	HYPH
cord-252230-s1qd3x1b	285	69	dependent	dependent	JJ
cord-252230-s1qd3x1b	285	70	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	285	71	secretion	secretion	NN
cord-252230-s1qd3x1b	285	72	pathway	pathway	NN
cord-252230-s1qd3x1b	285	73	Genetic	genetic	JJ
cord-252230-s1qd3x1b	285	74	and	and	CC
cord-252230-s1qd3x1b	285	75	phenotypic	phenotypic	JJ
cord-252230-s1qd3x1b	285	76	overlap	overlap	VBP
cord-252230-s1qd3x1b	285	77	between	between	IN
cord-252230-s1qd3x1b	285	78	autophagy	autophagy	NN
cord-252230-s1qd3x1b	285	79	and	and	CC
cord-252230-s1qd3x1b	285	80	the	the	DT
cord-252230-s1qd3x1b	285	81	cytoplasm	cytoplasm	NN
cord-252230-s1qd3x1b	285	82	to	to	IN
cord-252230-s1qd3x1b	285	83	vacuole	vacuole	NN
cord-252230-s1qd3x1b	285	84	protein	protein	NN
cord-252230-s1qd3x1b	285	85	targeting	target	VBG
cord-252230-s1qd3x1b	285	86	pathway	pathway	NN
cord-252230-s1qd3x1b	285	87	Genome	Genome	NNP
cord-252230-s1qd3x1b	285	88	-	-	HYPH
cord-252230-s1qd3x1b	285	89	wide	wide	JJ
cord-252230-s1qd3x1b	285	90	association	association	NN
cord-252230-s1qd3x1b	285	91	scan	scan	NN
cord-252230-s1qd3x1b	285	92	in	in	IN
cord-252230-s1qd3x1b	285	93	women	woman	NNS
cord-252230-s1qd3x1b	285	94	with	with	IN
cord-252230-s1qd3x1b	285	95	systemic	systemic	JJ
cord-252230-s1qd3x1b	285	96	lupus	lupus	NN
cord-252230-s1qd3x1b	286	1	erythematosus	erythematosus	NN
cord-252230-s1qd3x1b	286	2	identifies	identify	VBZ
cord-252230-s1qd3x1b	286	3	susceptibility	susceptibility	NN
cord-252230-s1qd3x1b	286	4	variants	variant	NNS
cord-252230-s1qd3x1b	286	5	in	in	IN
cord-252230-s1qd3x1b	286	6	ITG	ITG	NNP
cord-252230-s1qd3x1b	286	7	AM	AM	NNP
cord-252230-s1qd3x1b	286	8	,	,	,
cord-252230-s1qd3x1b	286	9	PXK	PXK	NNP
cord-252230-s1qd3x1b	286	10	,	,	,
cord-252230-s1qd3x1b	286	11	KIAA1542	KIAA1542	NNP
cord-252230-s1qd3x1b	286	12	and	and	CC
cord-252230-s1qd3x1b	286	13	other	other	JJ
cord-252230-s1qd3x1b	286	14	loci	locus	NNS
cord-252230-s1qd3x1b	287	1	Noncanonical	noncanonical	JJ
cord-252230-s1qd3x1b	287	2	autophagy	autophagy	NN
cord-252230-s1qd3x1b	287	3	is	be	VBZ
cord-252230-s1qd3x1b	287	4	required	require	VBN
cord-252230-s1qd3x1b	287	5	for	for	IN
cord-252230-s1qd3x1b	287	6	type	type	NN
cord-252230-s1qd3x1b	288	1	I	-PRON-	PRP
cord-252230-s1qd3x1b	288	2	interferon	interferon	VBD
cord-252230-s1qd3x1b	288	3	secretion	secretion	NN
cord-252230-s1qd3x1b	288	4	in	in	IN
cord-252230-s1qd3x1b	288	5	response	response	NN
cord-252230-s1qd3x1b	288	6	to	to	IN
cord-252230-s1qd3x1b	288	7	DNAimmune	DNAimmune	NNP
cord-252230-s1qd3x1b	288	8	complexes	complex	NNS
cord-252230-s1qd3x1b	289	1	IRF-7	IRF-7	NNP
cord-252230-s1qd3x1b	289	2	is	be	VBZ
cord-252230-s1qd3x1b	289	3	the	the	DT
cord-252230-s1qd3x1b	289	4	master	master	NN
cord-252230-s1qd3x1b	289	5	regulator	regulator	NN
cord-252230-s1qd3x1b	289	6	of	of	IN
cord-252230-s1qd3x1b	289	7	type	type	NN
cord-252230-s1qd3x1b	289	8	-	-	:
cord-252230-s1qd3x1b	289	9	I	-PRON-	PRP
cord-252230-s1qd3x1b	289	10	interferon	interferon	NN
cord-252230-s1qd3x1b	289	11	-	-	HYPH
cord-252230-s1qd3x1b	289	12	dependent	dependent	JJ
cord-252230-s1qd3x1b	289	13	immune	immune	JJ
cord-252230-s1qd3x1b	289	14	responses	response	NNS
cord-252230-s1qd3x1b	289	15	Activation	Activation	NNP
cord-252230-s1qd3x1b	289	16	of	of	IN
cord-252230-s1qd3x1b	289	17	antibacterial	antibacterial	JJ
cord-252230-s1qd3x1b	289	18	autophagy	autophagy	NN
cord-252230-s1qd3x1b	289	19	by	by	IN
cord-252230-s1qd3x1b	289	20	NAD	NAD	NNP
cord-252230-s1qd3x1b	289	21	PH	PH	NNP
cord-252230-s1qd3x1b	289	22	oxidases	oxidase	NNS
cord-252230-s1qd3x1b	289	23	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	289	24	gene	gene	NN
cord-252230-s1qd3x1b	290	1	Atg16L1	Atg16L1	NNP
cord-252230-s1qd3x1b	290	2	prevents	prevent	VBZ
cord-252230-s1qd3x1b	290	3	lethal	lethal	JJ
cord-252230-s1qd3x1b	290	4	T	t	NN
cord-252230-s1qd3x1b	290	5	cell	cell	NN
cord-252230-s1qd3x1b	290	6	alloreactivity	alloreactivity	NN
cord-252230-s1qd3x1b	290	7	mediated	mediate	VBN
cord-252230-s1qd3x1b	290	8	by	by	IN
cord-252230-s1qd3x1b	290	9	dendritic	dendritic	JJ
cord-252230-s1qd3x1b	290	10	cells	cell	NNS
cord-252230-s1qd3x1b	290	11	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	290	12	in	in	IN
cord-252230-s1qd3x1b	290	13	antigen	antigen	NN
cord-252230-s1qd3x1b	290	14	-	-	HYPH
cord-252230-s1qd3x1b	290	15	presenting	present	VBG
cord-252230-s1qd3x1b	290	16	cells	cell	NNS
cord-252230-s1qd3x1b	291	1	results	result	NNS
cord-252230-s1qd3x1b	291	2	in	in	IN
cord-252230-s1qd3x1b	291	3	presentation	presentation	NN
cord-252230-s1qd3x1b	291	4	of	of	IN
cord-252230-s1qd3x1b	291	5	citrullinated	citrullinate	VBN
cord-252230-s1qd3x1b	291	6	peptides	peptide	NNS
cord-252230-s1qd3x1b	291	7	to	to	IN
cord-252230-s1qd3x1b	291	8	CD4	CD4	NNP
cord-252230-s1qd3x1b	291	9	T	T	NNP
cord-252230-s1qd3x1b	291	10	cells	cell	VBZ
cord-252230-s1qd3x1b	291	11	Subversion	subversion	NN
cord-252230-s1qd3x1b	291	12	of	of	IN
cord-252230-s1qd3x1b	291	13	cellular	cellular	JJ
cord-252230-s1qd3x1b	291	14	autophagosomal	autophagosomal	NN
cord-252230-s1qd3x1b	291	15	machinery	machinery	NN
cord-252230-s1qd3x1b	291	16	by	by	IN
cord-252230-s1qd3x1b	291	17	RNA	RNA	NNP
cord-252230-s1qd3x1b	291	18	viruses	virus	NNS
cord-252230-s1qd3x1b	292	1	The	the	DT
cord-252230-s1qd3x1b	292	2	Atg5	Atg5	NNP
cord-252230-s1qd3x1b	292	3	Atg12	Atg12	NNP
cord-252230-s1qd3x1b	292	4	conjugate	conjugate	NN
cord-252230-s1qd3x1b	292	5	associates	associate	NNS
cord-252230-s1qd3x1b	292	6	with	with	IN
cord-252230-s1qd3x1b	292	7	innate	innate	JJ
cord-252230-s1qd3x1b	292	8	antiviral	antiviral	JJ
cord-252230-s1qd3x1b	292	9	immune	immune	JJ
cord-252230-s1qd3x1b	292	10	responses	response	NNS
cord-252230-s1qd3x1b	293	1	The	the	DT
cord-252230-s1qd3x1b	293	2	autophagy	autophagy	NN
cord-252230-s1qd3x1b	293	3	gene	gene	NN
cord-252230-s1qd3x1b	293	4	Atg16l1	Atg16l1	NNS
cord-252230-s1qd3x1b	293	5	differentially	differentially	RB
cord-252230-s1qd3x1b	293	6	regulates	regulate	VBZ
cord-252230-s1qd3x1b	293	7	Treg	Treg	NNP
cord-252230-s1qd3x1b	293	8	and	and	CC
cord-252230-s1qd3x1b	293	9	TH2	TH2	NNP
cord-252230-s1qd3x1b	293	10	cells	cell	NNS
cord-252230-s1qd3x1b	293	11	to	to	TO
cord-252230-s1qd3x1b	293	12	control	control	VB
cord-252230-s1qd3x1b	293	13	intestinal	intestinal	JJ
cord-252230-s1qd3x1b	293	14	inflammation	inflammation	NN
cord-252230-s1qd3x1b	293	15	.	.	.
cord-252230-s1qd3x1b	294	1	eLife	eLife	NNP
cord-252230-s1qd3x1b	294	2	.	.	.
cord-252230-s1qd3x1b	295	1	5	5	LS
cord-252230-s1qd3x1b	296	1	:	:	:
cord-252230-s1qd3x1b	297	1	e12444	e12444	NNP
cord-252230-s1qd3x1b	297	2	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	297	3	at	at	IN
cord-252230-s1qd3x1b	297	4	the	the	DT
cord-252230-s1qd3x1b	297	5	crossroads	crossroad	NNS
cord-252230-s1qd3x1b	297	6	of	of	IN
cord-252230-s1qd3x1b	297	7	catabolism	catabolism	NN
cord-252230-s1qd3x1b	297	8	and	and	CC
cord-252230-s1qd3x1b	297	9	anabolism	anabolism	NN
cord-252230-s1qd3x1b	297	10	IPS-1	IPS-1	NNP
cord-252230-s1qd3x1b	297	11	,	,	,
cord-252230-s1qd3x1b	298	1	an	an	DT
cord-252230-s1qd3x1b	298	2	adaptor	adaptor	NN
cord-252230-s1qd3x1b	298	3	triggering	trigger	VBG
cord-252230-s1qd3x1b	298	4	RIG	rig	NN
cord-252230-s1qd3x1b	298	5	-	-	HYPH
cord-252230-s1qd3x1b	298	6	I	i	NN
cord-252230-s1qd3x1b	298	7	-	-	HYPH
cord-252230-s1qd3x1b	298	8	and	and	CC
cord-252230-s1qd3x1b	298	9	Mda5-mediated	Mda5-mediated	NNP
cord-252230-s1qd3x1b	298	10	type	type	NN
cord-252230-s1qd3x1b	299	1	I	-PRON-	PRP
cord-252230-s1qd3x1b	299	2	interferon	interferon	RB
cord-252230-s1qd3x1b	299	3	induction	induction	NN
cord-252230-s1qd3x1b	300	1	An	an	DT
cord-252230-s1qd3x1b	300	2	enteric	enteric	JJ
cord-252230-s1qd3x1b	300	3	virus	virus	NN
cord-252230-s1qd3x1b	300	4	can	can	MD
cord-252230-s1qd3x1b	300	5	replace	replace	VB
cord-252230-s1qd3x1b	300	6	the	the	DT
cord-252230-s1qd3x1b	300	7	beneficial	beneficial	JJ
cord-252230-s1qd3x1b	300	8	function	function	NN
cord-252230-s1qd3x1b	300	9	of	of	IN
cord-252230-s1qd3x1b	300	10	commensal	commensal	JJ
cord-252230-s1qd3x1b	300	11	bacteria	bacteria	NNS
cord-252230-s1qd3x1b	300	12	Noncanonical	noncanonical	JJ
cord-252230-s1qd3x1b	300	13	autophagy	autophagy	NN
cord-252230-s1qd3x1b	300	14	promotes	promote	VBZ
cord-252230-s1qd3x1b	300	15	the	the	DT
cord-252230-s1qd3x1b	300	16	visual	visual	JJ
cord-252230-s1qd3x1b	300	17	cycle	cycle	NN
cord-252230-s1qd3x1b	300	18	Unique	unique	JJ
cord-252230-s1qd3x1b	300	19	role	role	NN
cord-252230-s1qd3x1b	300	20	for	for	IN
cord-252230-s1qd3x1b	300	21	ATG5	ATG5	NNP
cord-252230-s1qd3x1b	300	22	in	in	IN
cord-252230-s1qd3x1b	300	23	neutrophil	neutrophil	NN
cord-252230-s1qd3x1b	300	24	-	-	HYPH
cord-252230-s1qd3x1b	300	25	mediated	mediate	VBN
cord-252230-s1qd3x1b	300	26	immunopathology	immunopathology	NN
cord-252230-s1qd3x1b	300	27	during	during	IN
cord-252230-s1qd3x1b	300	28	M.	M.	NNP
cord-252230-s1qd3x1b	300	29	tuberculosis	tuberculosis	NN
cord-252230-s1qd3x1b	300	30	infection	infection	NN
cord-252230-s1qd3x1b	300	31	Dedicated	dedicated	JJ
cord-252230-s1qd3x1b	300	32	SNA	SNA	NNP
cord-252230-s1qd3x1b	300	33	REs	re	NNS
cord-252230-s1qd3x1b	300	34	and	and	CC
cord-252230-s1qd3x1b	300	35	specialized	specialized	JJ
cord-252230-s1qd3x1b	300	36	TRIM	trim	NN
cord-252230-s1qd3x1b	300	37	cargo	cargo	NN
cord-252230-s1qd3x1b	300	38	receptors	receptor	NNS
cord-252230-s1qd3x1b	300	39	mediate	mediate	VBP
cord-252230-s1qd3x1b	300	40	secretory	secretory	JJ
cord-252230-s1qd3x1b	300	41	autophagy	autophagy	NN
cord-252230-s1qd3x1b	300	42	Cyclic	Cyclic	NNP
cord-252230-s1qd3x1b	300	43	dinucleotides	dinucleotide	NNS
cord-252230-s1qd3x1b	301	1	trigger	trigger	NN
cord-252230-s1qd3x1b	301	2	ULK1	ULK1	NNP
cord-252230-s1qd3x1b	301	3	(	(	-LRB-
cord-252230-s1qd3x1b	301	4	ATG1	ATG1	NNP
cord-252230-s1qd3x1b	301	5	)	)	-RRB-
cord-252230-s1qd3x1b	301	6	phosphorylation	phosphorylation	NN
cord-252230-s1qd3x1b	301	7	of	of	IN
cord-252230-s1qd3x1b	301	8	STI	STI	NNP
cord-252230-s1qd3x1b	301	9	NG	NG	NNP
cord-252230-s1qd3x1b	301	10	to	to	TO
cord-252230-s1qd3x1b	301	11	prevent	prevent	VB
cord-252230-s1qd3x1b	301	12	sustained	sustained	JJ
cord-252230-s1qd3x1b	301	13	innate	innate	JJ
cord-252230-s1qd3x1b	301	14	immune	immune	NN
cord-252230-s1qd3x1b	301	15	signaling	signal	VBG
cord-252230-s1qd3x1b	301	16	Inhibition	inhibition	NN
cord-252230-s1qd3x1b	301	17	of	of	IN
cord-252230-s1qd3x1b	301	18	Avian	Avian	NNP
cord-252230-s1qd3x1b	301	19	Influenza	Influenza	NNP
cord-252230-s1qd3x1b	301	20	A	A	NNP
cord-252230-s1qd3x1b	301	21	Virus	virus	NN
cord-252230-s1qd3x1b	301	22	Replication	Replication	NNP
cord-252230-s1qd3x1b	301	23	in	in	IN
cord-252230-s1qd3x1b	301	24	Human	Human	NNP
cord-252230-s1qd3x1b	301	25	Cells	Cells	NNPS
cord-252230-s1qd3x1b	301	26	by	by	IN
cord-252230-s1qd3x1b	301	27	Host	Host	NNP
cord-252230-s1qd3x1b	301	28	Restriction	Restriction	NNP
cord-252230-s1qd3x1b	301	29	Factor	Factor	NNP
cord-252230-s1qd3x1b	301	30	TUFM	TUFM	NNP
cord-252230-s1qd3x1b	302	1	Is	be	VBZ
cord-252230-s1qd3x1b	302	2	Correlated	correlate	VBN
cord-252230-s1qd3x1b	302	3	with	with	IN
cord-252230-s1qd3x1b	302	4	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	302	5	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	302	6	pathway	pathway	NN
cord-252230-s1qd3x1b	302	7	intersects	intersect	VBZ
cord-252230-s1qd3x1b	302	8	with	with	IN
cord-252230-s1qd3x1b	302	9	HIV-1	HIV-1	NNP
cord-252230-s1qd3x1b	302	10	biosynthesis	biosynthesis	NN
cord-252230-s1qd3x1b	302	11	and	and	CC
cord-252230-s1qd3x1b	302	12	regulates	regulate	VBZ
cord-252230-s1qd3x1b	302	13	viral	viral	JJ
cord-252230-s1qd3x1b	302	14	yields	yield	NNS
cord-252230-s1qd3x1b	302	15	in	in	IN
cord-252230-s1qd3x1b	302	16	macrophages	macrophage	NNS
cord-252230-s1qd3x1b	302	17	Genetic	genetic	JJ
cord-252230-s1qd3x1b	302	18	control	control	NN
cord-252230-s1qd3x1b	302	19	of	of	IN
cord-252230-s1qd3x1b	302	20	autophagy	autophagy	NN
cord-252230-s1qd3x1b	302	21	underlies	underlie	VBZ
cord-252230-s1qd3x1b	302	22	pathogenesis	pathogenesis	NN
cord-252230-s1qd3x1b	302	23	of	of	IN
cord-252230-s1qd3x1b	302	24	inflammatory	inflammatory	JJ
cord-252230-s1qd3x1b	302	25	bowel	bowel	NN
cord-252230-s1qd3x1b	302	26	disease	disease	NN
cord-252230-s1qd3x1b	303	1	Atg16L1	Atg16L1	NNP
cord-252230-s1qd3x1b	303	2	T300A	T300A	NNP
cord-252230-s1qd3x1b	303	3	variant	variant	NN
cord-252230-s1qd3x1b	303	4	decreases	decrease	VBZ
cord-252230-s1qd3x1b	303	5	selective	selective	JJ
cord-252230-s1qd3x1b	303	6	autophagy	autophagy	NN
cord-252230-s1qd3x1b	303	7	resulting	result	VBG
cord-252230-s1qd3x1b	303	8	in	in	IN
cord-252230-s1qd3x1b	303	9	altered	altered	JJ
cord-252230-s1qd3x1b	303	10	cytokine	cytokine	NN
cord-252230-s1qd3x1b	303	11	signaling	signaling	NN
cord-252230-s1qd3x1b	303	12	and	and	CC
cord-252230-s1qd3x1b	303	13	decreased	decrease	VBD
cord-252230-s1qd3x1b	303	14	antibacterial	antibacterial	JJ
cord-252230-s1qd3x1b	303	15	defense	defense	NN
cord-252230-s1qd3x1b	304	1	The	the	DT
cord-252230-s1qd3x1b	304	2	mitochondrial	mitochondrial	JJ
cord-252230-s1qd3x1b	304	3	proteins	protein	NNS
cord-252230-s1qd3x1b	305	1	NLRX1	NLRX1	NNP
cord-252230-s1qd3x1b	306	1	and	and	CC
cord-252230-s1qd3x1b	306	2	TUFM	TUFM	NNP
cord-252230-s1qd3x1b	306	3	form	form	VBP
cord-252230-s1qd3x1b	306	4	a	a	DT
cord-252230-s1qd3x1b	306	5	complex	complex	NN
cord-252230-s1qd3x1b	306	6	that	that	WDT
cord-252230-s1qd3x1b	306	7	regulates	regulate	VBZ
cord-252230-s1qd3x1b	306	8	type	type	NN
cord-252230-s1qd3x1b	307	1	I	-PRON-	PRP
cord-252230-s1qd3x1b	307	2	interferon	interferon	VBD
cord-252230-s1qd3x1b	307	3	and	and	CC
cord-252230-s1qd3x1b	307	4	autophagy	autophagy	VBP
cord-252230-s1qd3x1b	307	5	Dengue	Dengue	NNP
cord-252230-s1qd3x1b	307	6	and	and	CC
cord-252230-s1qd3x1b	307	7	Zika	Zika	NNP
cord-252230-s1qd3x1b	307	8	viruses	virus	NNS
cord-252230-s1qd3x1b	307	9	subvert	subvert	VBP
cord-252230-s1qd3x1b	307	10	reticulophagy	reticulophagy	NNS
cord-252230-s1qd3x1b	307	11	by	by	IN
cord-252230-s1qd3x1b	307	12	NS2B3-mediated	ns2b3-mediated	JJ
cord-252230-s1qd3x1b	307	13	cleavage	cleavage	NN
cord-252230-s1qd3x1b	307	14	of	of	IN
cord-252230-s1qd3x1b	307	15	FAM134B	FAM134B	NNP
cord-252230-s1qd3x1b	307	16	Crosstalk	crosstalk	NN
cord-252230-s1qd3x1b	307	17	between	between	IN
cord-252230-s1qd3x1b	307	18	the	the	DT
cord-252230-s1qd3x1b	307	19	cGAS	cgas	JJ
cord-252230-s1qd3x1b	307	20	DNA	dna	NN
cord-252230-s1qd3x1b	307	21	sensor	sensor	NN
cord-252230-s1qd3x1b	307	22	and	and	CC
cord-252230-s1qd3x1b	307	23	Beclin-1	Beclin-1	NNP
cord-252230-s1qd3x1b	308	1	autophagy	autophagy	NN
cord-252230-s1qd3x1b	308	2	protein	protein	NN
cord-252230-s1qd3x1b	308	3	shapes	shape	NNS
cord-252230-s1qd3x1b	308	4	innate	innate	VBP
cord-252230-s1qd3x1b	308	5	antimicrobial	antimicrobial	JJ
cord-252230-s1qd3x1b	308	6	immune	immune	JJ
cord-252230-s1qd3x1b	308	7	responses	response	NNS
cord-252230-s1qd3x1b	309	1	Autophagydependent	Autophagydependent	NNP
cord-252230-s1qd3x1b	309	2	production	production	NN
cord-252230-s1qd3x1b	309	3	of	of	IN
cord-252230-s1qd3x1b	309	4	secreted	secrete	VBN
cord-252230-s1qd3x1b	309	5	factors	factor	NNS
cord-252230-s1qd3x1b	309	6	facilitates	facilitate	VBZ
cord-252230-s1qd3x1b	309	7	oncogenic	oncogenic	JJ
cord-252230-s1qd3x1b	309	8	RASdriven	rasdriven	JJ
cord-252230-s1qd3x1b	309	9	invasion	invasion	NN
cord-252230-s1qd3x1b	309	10	Homeostatic	Homeostatic	NNP
cord-252230-s1qd3x1b	309	11	Control	Control	NNP
cord-252230-s1qd3x1b	309	12	of	of	IN
cord-252230-s1qd3x1b	309	13	Innate	Innate	NNP
cord-252230-s1qd3x1b	309	14	Lung	Lung	NNP
cord-252230-s1qd3x1b	309	15	Inflammation	inflammation	NN
cord-252230-s1qd3x1b	309	16	by	by	IN
cord-252230-s1qd3x1b	309	17	Vici	Vici	NNP
cord-252230-s1qd3x1b	309	18	Syndrome	Syndrome	NNP
cord-252230-s1qd3x1b	309	19	Gene	Gene	NNP
cord-252230-s1qd3x1b	309	20	Epg5	Epg5	NNP
cord-252230-s1qd3x1b	309	21	and	and	CC
cord-252230-s1qd3x1b	309	22	Additional	Additional	NNP
cord-252230-s1qd3x1b	309	23	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	309	24	Genes	Genes	NNPS
cord-252230-s1qd3x1b	309	25	Promotes	promote	VBZ
cord-252230-s1qd3x1b	309	26	Influenza	Influenza	NNP
cord-252230-s1qd3x1b	309	27	Pathogenesis	Pathogenesis	NNP
cord-252230-s1qd3x1b	309	28	Unconventional	Unconventional	NNP
cord-252230-s1qd3x1b	309	29	protein	protein	NN
cord-252230-s1qd3x1b	309	30	secretion	secretion	NN
cord-252230-s1qd3x1b	309	31	:	:	:
cord-252230-s1qd3x1b	309	32	an	an	DT
cord-252230-s1qd3x1b	309	33	evolving	evolve	VBG
cord-252230-s1qd3x1b	309	34	mechanism	mechanism	NN
cord-252230-s1qd3x1b	309	35	Unconventional	unconventional	JJ
cord-252230-s1qd3x1b	309	36	secretion	secretion	NN
cord-252230-s1qd3x1b	309	37	of	of	IN
cord-252230-s1qd3x1b	309	38	Pichia	Pichia	NNP
cord-252230-s1qd3x1b	309	39	pastoris	pastoris	NN
cord-252230-s1qd3x1b	309	40	Acb1	Acb1	NNP
cord-252230-s1qd3x1b	309	41	is	be	VBZ
cord-252230-s1qd3x1b	309	42	dependent	dependent	JJ
cord-252230-s1qd3x1b	309	43	on	on	IN
cord-252230-s1qd3x1b	309	44	GRA	GRA	NNP
cord-252230-s1qd3x1b	309	45	SP	SP	NNP
cord-252230-s1qd3x1b	309	46	protein	protein	NN
cord-252230-s1qd3x1b	309	47	,	,	,
cord-252230-s1qd3x1b	309	48	peroxisomal	peroxisomal	JJ
cord-252230-s1qd3x1b	309	49	functions	function	NNS
cord-252230-s1qd3x1b	309	50	,	,	,
cord-252230-s1qd3x1b	309	51	and	and	CC
cord-252230-s1qd3x1b	309	52	autophagosome	autophagosome	JJ
cord-252230-s1qd3x1b	309	53	formation	formation	NN
cord-252230-s1qd3x1b	310	1	A	a	DT
cord-252230-s1qd3x1b	310	2	deficiency	deficiency	NN
cord-252230-s1qd3x1b	310	3	in	in	IN
cord-252230-s1qd3x1b	310	4	the	the	DT
cord-252230-s1qd3x1b	310	5	autophagy	autophagy	NN
cord-252230-s1qd3x1b	310	6	gene	gene	NN
cord-252230-s1qd3x1b	310	7	Atg16L1	Atg16L1	NNP
cord-252230-s1qd3x1b	310	8	enhances	enhance	VBZ
cord-252230-s1qd3x1b	310	9	resistance	resistance	NN
cord-252230-s1qd3x1b	310	10	to	to	IN
cord-252230-s1qd3x1b	310	11	enteric	enteric	JJ
cord-252230-s1qd3x1b	310	12	bacterial	bacterial	JJ
cord-252230-s1qd3x1b	310	13	infection	infection	NN
cord-252230-s1qd3x1b	310	14	Microtubule	Microtubule	NNP
cord-252230-s1qd3x1b	310	15	-	-	HYPH
cord-252230-s1qd3x1b	310	16	associated	associate	VBN
cord-252230-s1qd3x1b	310	17	protein	protein	NN
cord-252230-s1qd3x1b	310	18	1	1	CD
cord-252230-s1qd3x1b	310	19	light	light	NN
cord-252230-s1qd3x1b	310	20	chain	chain	NN
cord-252230-s1qd3x1b	310	21	3	3	CD
cord-252230-s1qd3x1b	310	22	alpha	alpha	NN
cord-252230-s1qd3x1b	310	23	(	(	-LRB-
cord-252230-s1qd3x1b	310	24	LC3)-associated	lc3)-associated	JJ
cord-252230-s1qd3x1b	310	25	phagocytosis	phagocytosis	NN
cord-252230-s1qd3x1b	310	26	is	be	VBZ
cord-252230-s1qd3x1b	310	27	required	require	VBN
cord-252230-s1qd3x1b	310	28	for	for	IN
cord-252230-s1qd3x1b	310	29	the	the	DT
cord-252230-s1qd3x1b	310	30	efficient	efficient	JJ
cord-252230-s1qd3x1b	310	31	clearance	clearance	NN
cord-252230-s1qd3x1b	310	32	of	of	IN
cord-252230-s1qd3x1b	310	33	dead	dead	JJ
cord-252230-s1qd3x1b	310	34	cells	cell	NNS
cord-252230-s1qd3x1b	311	1	Molecular	molecular	JJ
cord-252230-s1qd3x1b	311	2	characterization	characterization	NN
cord-252230-s1qd3x1b	311	3	of	of	IN
cord-252230-s1qd3x1b	311	4	LC3-associated	lc3-associate	VBN
cord-252230-s1qd3x1b	311	5	phagocytosis	phagocytosis	NN
cord-252230-s1qd3x1b	311	6	reveals	reveal	VBZ
cord-252230-s1qd3x1b	311	7	distinct	distinct	JJ
cord-252230-s1qd3x1b	311	8	roles	role	NNS
cord-252230-s1qd3x1b	311	9	for	for	IN
cord-252230-s1qd3x1b	311	10	Rubicon	Rubicon	NNP
cord-252230-s1qd3x1b	311	11	,	,	,
cord-252230-s1qd3x1b	311	12	NOX2	NOX2	NNP
cord-252230-s1qd3x1b	311	13	and	and	CC
cord-252230-s1qd3x1b	311	14	autophagy	autophagy	NN
cord-252230-s1qd3x1b	311	15	proteins	protein	NNS
cord-252230-s1qd3x1b	312	1	Noncanonical	noncanonical	JJ
cord-252230-s1qd3x1b	312	2	autophagy	autophagy	NN
cord-252230-s1qd3x1b	312	3	inhibits	inhibit	VBZ
cord-252230-s1qd3x1b	312	4	the	the	DT
cord-252230-s1qd3x1b	312	5	autoinflammatory	autoinflammatory	NN
cord-252230-s1qd3x1b	312	6	,	,	,
cord-252230-s1qd3x1b	312	7	lupus	lupus	NN
cord-252230-s1qd3x1b	312	8	-	-	HYPH
cord-252230-s1qd3x1b	312	9	like	like	JJ
cord-252230-s1qd3x1b	312	10	response	response	NN
cord-252230-s1qd3x1b	312	11	to	to	IN
cord-252230-s1qd3x1b	312	12	dying	die	VBG
cord-252230-s1qd3x1b	312	13	cells	cell	NNS
cord-252230-s1qd3x1b	313	1	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	313	2	protein	protein	NN
cord-252230-s1qd3x1b	314	1	ATG16L1	ATG16L1	NNP
cord-252230-s1qd3x1b	314	2	prevents	prevent	VBZ
cord-252230-s1qd3x1b	314	3	necroptosis	necroptosis	NN
cord-252230-s1qd3x1b	314	4	in	in	IN
cord-252230-s1qd3x1b	314	5	the	the	DT
cord-252230-s1qd3x1b	314	6	intestinal	intestinal	JJ
cord-252230-s1qd3x1b	314	7	epithelium	epithelium	NN
cord-252230-s1qd3x1b	315	1	An	an	DT
cord-252230-s1qd3x1b	315	2	siRNA	siRNA	NNP
cord-252230-s1qd3x1b	315	3	screen	screen	NN
cord-252230-s1qd3x1b	315	4	for	for	IN
cord-252230-s1qd3x1b	315	5	ATG	ATG	NNP
cord-252230-s1qd3x1b	315	6	protein	protein	NN
cord-252230-s1qd3x1b	315	7	depletion	depletion	NN
cord-252230-s1qd3x1b	315	8	reveals	reveal	VBZ
cord-252230-s1qd3x1b	315	9	the	the	DT
cord-252230-s1qd3x1b	315	10	extent	extent	NN
cord-252230-s1qd3x1b	315	11	of	of	IN
cord-252230-s1qd3x1b	315	12	the	the	DT
cord-252230-s1qd3x1b	315	13	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	315	14	functions	function	NNS
cord-252230-s1qd3x1b	315	15	of	of	IN
cord-252230-s1qd3x1b	315	16	the	the	DT
cord-252230-s1qd3x1b	315	17	autophagy	autophagy	NN
cord-252230-s1qd3x1b	315	18	proteome	proteome	NN
cord-252230-s1qd3x1b	315	19	in	in	IN
cord-252230-s1qd3x1b	315	20	virus	virus	NN
cord-252230-s1qd3x1b	315	21	replication	replication	NN
cord-252230-s1qd3x1b	315	22	PLE	PLE	NNP
cord-252230-s1qd3x1b	315	23	KHM1	KHM1	NNP
cord-252230-s1qd3x1b	315	24	regulates	regulate	VBZ
cord-252230-s1qd3x1b	315	25	autophagosome	autophagosome	NN
cord-252230-s1qd3x1b	315	26	-	-	HYPH
cord-252230-s1qd3x1b	315	27	lysosome	lysosome	NN
cord-252230-s1qd3x1b	315	28	fusion	fusion	NN
cord-252230-s1qd3x1b	315	29	through	through	IN
cord-252230-s1qd3x1b	315	30	HOPS	HOPS	NNP
cord-252230-s1qd3x1b	315	31	complex	complex	JJ
cord-252230-s1qd3x1b	315	32	and	and	CC
cord-252230-s1qd3x1b	316	1	LC3	LC3	NNP
cord-252230-s1qd3x1b	316	2	/	/	SYM
cord-252230-s1qd3x1b	316	3	GAB	GAB	NNP
cord-252230-s1qd3x1b	316	4	ARAP	ARAP	NNP
cord-252230-s1qd3x1b	316	5	proteins	protein	VBZ
cord-252230-s1qd3x1b	316	6	Caspase-11	caspase-11	VBP
cord-252230-s1qd3x1b	316	7	activation	activation	NN
cord-252230-s1qd3x1b	316	8	requires	require	VBZ
cord-252230-s1qd3x1b	316	9	lysis	lysis	NN
cord-252230-s1qd3x1b	316	10	of	of	IN
cord-252230-s1qd3x1b	316	11	pathogen	pathogen	NN
cord-252230-s1qd3x1b	316	12	-	-	HYPH
cord-252230-s1qd3x1b	316	13	containing	contain	VBG
cord-252230-s1qd3x1b	316	14	vacuoles	vacuole	NNS
cord-252230-s1qd3x1b	316	15	by	by	IN
cord-252230-s1qd3x1b	316	16	IFN	IFN	NNP
cord-252230-s1qd3x1b	316	17	-	-	HYPH
cord-252230-s1qd3x1b	316	18	induced	induce	VBN
cord-252230-s1qd3x1b	316	19	GTPases	GTPases	NNP
cord-252230-s1qd3x1b	316	20	Cardif	Cardif	NNP
cord-252230-s1qd3x1b	317	1	is	be	VBZ
cord-252230-s1qd3x1b	317	2	an	an	DT
cord-252230-s1qd3x1b	317	3	adaptor	adaptor	NN
cord-252230-s1qd3x1b	317	4	protein	protein	NN
cord-252230-s1qd3x1b	317	5	in	in	IN
cord-252230-s1qd3x1b	317	6	the	the	DT
cord-252230-s1qd3x1b	317	7	RIG	rig	NN
cord-252230-s1qd3x1b	317	8	-	-	:
cord-252230-s1qd3x1b	317	9	I	I	NNP
cord-252230-s1qd3x1b	317	10	antiviral	antiviral	JJ
cord-252230-s1qd3x1b	317	11	pathway	pathway	NN
cord-252230-s1qd3x1b	317	12	and	and	CC
cord-252230-s1qd3x1b	317	13	is	be	VBZ
cord-252230-s1qd3x1b	317	14	targeted	target	VBN
cord-252230-s1qd3x1b	317	15	by	by	IN
cord-252230-s1qd3x1b	317	16	hepatitis	hepatitis	NN
cord-252230-s1qd3x1b	317	17	C	C	NNP
cord-252230-s1qd3x1b	317	18	virus	virus	NN
cord-252230-s1qd3x1b	318	1	The	the	DT
cord-252230-s1qd3x1b	318	2	role	role	NN
cord-252230-s1qd3x1b	318	3	of	of	IN
cord-252230-s1qd3x1b	318	4	Atg	Atg	NNP
cord-252230-s1qd3x1b	318	5	proteins	protein	NNS
cord-252230-s1qd3x1b	318	6	in	in	IN
cord-252230-s1qd3x1b	318	7	autophagosome	autophagosome	JJ
cord-252230-s1qd3x1b	318	8	formation	formation	NN
cord-252230-s1qd3x1b	319	1	A	a	DT
cord-252230-s1qd3x1b	319	2	Crohn	Crohn	NNP
cord-252230-s1qd3x1b	319	3	's	's	POS
cord-252230-s1qd3x1b	319	4	disease	disease	NN
cord-252230-s1qd3x1b	319	5	variant	variant	NN
cord-252230-s1qd3x1b	319	6	in	in	IN
cord-252230-s1qd3x1b	319	7	Atg16l1	Atg16l1	NNP
cord-252230-s1qd3x1b	319	8	enhances	enhance	VBZ
cord-252230-s1qd3x1b	319	9	its	-PRON-	PRP$
cord-252230-s1qd3x1b	319	10	degradation	degradation	NN
cord-252230-s1qd3x1b	319	11	by	by	IN
cord-252230-s1qd3x1b	319	12	caspase	caspase	NN
cord-252230-s1qd3x1b	319	13	3	3	CD
cord-252230-s1qd3x1b	319	14	Spatial	spatial	JJ
cord-252230-s1qd3x1b	319	15	coupling	coupling	NN
cord-252230-s1qd3x1b	319	16	of	of	IN
cord-252230-s1qd3x1b	319	17	mTOR	mtor	NN
cord-252230-s1qd3x1b	319	18	and	and	CC
cord-252230-s1qd3x1b	319	19	autophagy	autophagy	NN
cord-252230-s1qd3x1b	319	20	augments	augment	VBZ
cord-252230-s1qd3x1b	319	21	secretory	secretory	JJ
cord-252230-s1qd3x1b	319	22	phenotypes	phenotype	NNS
cord-252230-s1qd3x1b	319	23	Macroautophagy	Macroautophagy	NNP
cord-252230-s1qd3x1b	319	24	Proteins	Proteins	NNPS
cord-252230-s1qd3x1b	319	25	Assist	assist	VBP
cord-252230-s1qd3x1b	319	26	Epstein	Epstein	NNP
cord-252230-s1qd3x1b	319	27	Barr	Barr	NNP
cord-252230-s1qd3x1b	319	28	Virus	Virus	NNP
cord-252230-s1qd3x1b	319	29	Production	Production	NNP
cord-252230-s1qd3x1b	319	30	and	and	CC
cord-252230-s1qd3x1b	319	31	Get	get	VB
cord-252230-s1qd3x1b	319	32	Incorporated	incorporate	VBN
cord-252230-s1qd3x1b	319	33	Into	into	IN
cord-252230-s1qd3x1b	319	34	the	the	DT
cord-252230-s1qd3x1b	319	35	Virus	virus	NN
cord-252230-s1qd3x1b	319	36	Particles	particle	NNS
cord-252230-s1qd3x1b	319	37	.	.	.
cord-252230-s1qd3x1b	320	1	EBioMedicine	EBioMedicine	NNP
cord-252230-s1qd3x1b	320	2	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	320	3	Genes	Genes	NNPS
cord-252230-s1qd3x1b	320	4	Enhance	enhance	VBP
cord-252230-s1qd3x1b	320	5	Murine	Murine	NNP
cord-252230-s1qd3x1b	320	6	Gammaherpesvirus	Gammaherpesvirus	NNP
cord-252230-s1qd3x1b	320	7	68	68	CD
cord-252230-s1qd3x1b	320	8	Reactivation	Reactivation	NNP
cord-252230-s1qd3x1b	320	9	from	from	IN
cord-252230-s1qd3x1b	320	10	Latency	Latency	NNP
cord-252230-s1qd3x1b	320	11	by	by	IN
cord-252230-s1qd3x1b	320	12	Preventing	prevent	VBG
cord-252230-s1qd3x1b	320	13	Virus	Virus	NNP
cord-252230-s1qd3x1b	320	14	-	-	HYPH
cord-252230-s1qd3x1b	320	15	Induced	induce	VBN
cord-252230-s1qd3x1b	320	16	Systemic	systemic	JJ
cord-252230-s1qd3x1b	320	17	Inflammation	inflammation	NN
cord-252230-s1qd3x1b	320	18	Targeting	target	VBG
cord-252230-s1qd3x1b	320	19	by	by	IN
cord-252230-s1qd3x1b	320	20	AutophaGy	AutophaGy	NNP
cord-252230-s1qd3x1b	320	21	proteins	protein	NNS
cord-252230-s1qd3x1b	320	22	(	(	-LRB-
cord-252230-s1qd3x1b	320	23	TAG	tag	NN
cord-252230-s1qd3x1b	320	24	)	)	-RRB-
cord-252230-s1qd3x1b	320	25	:	:	:
cord-252230-s1qd3x1b	321	1	Targeting	target	VBG
cord-252230-s1qd3x1b	321	2	of	of	IN
cord-252230-s1qd3x1b	321	3	IFNGinducible	ifnginducible	JJ
cord-252230-s1qd3x1b	321	4	GTPases	gtpase	NNS
cord-252230-s1qd3x1b	321	5	to	to	IN
cord-252230-s1qd3x1b	321	6	membranes	membrane	NNS
cord-252230-s1qd3x1b	321	7	by	by	IN
cord-252230-s1qd3x1b	321	8	the	the	DT
cord-252230-s1qd3x1b	321	9	LC3	lc3	JJ
cord-252230-s1qd3x1b	321	10	conjugation	conjugation	NN
cord-252230-s1qd3x1b	321	11	system	system	NN
cord-252230-s1qd3x1b	321	12	of	of	IN
cord-252230-s1qd3x1b	321	13	autophagy	autophagy	NN
cord-252230-s1qd3x1b	321	14	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	321	15	proteins	protein	NNS
cord-252230-s1qd3x1b	321	16	control	control	VBP
cord-252230-s1qd3x1b	321	17	goblet	goblet	NN
cord-252230-s1qd3x1b	321	18	cell	cell	NN
cord-252230-s1qd3x1b	321	19	function	function	NN
cord-252230-s1qd3x1b	321	20	by	by	IN
cord-252230-s1qd3x1b	321	21	potentiating	potentiate	VBG
cord-252230-s1qd3x1b	321	22	reactive	reactive	JJ
cord-252230-s1qd3x1b	321	23	oxygen	oxygen	NN
cord-252230-s1qd3x1b	321	24	species	specie	NNS
cord-252230-s1qd3x1b	321	25	production	production	NN
cord-252230-s1qd3x1b	321	26	Plasma	plasma	NN
cord-252230-s1qd3x1b	321	27	cells	cell	NNS
cord-252230-s1qd3x1b	321	28	require	require	VBP
cord-252230-s1qd3x1b	321	29	autophagy	autophagy	NN
cord-252230-s1qd3x1b	321	30	for	for	IN
cord-252230-s1qd3x1b	321	31	sustainable	sustainable	JJ
cord-252230-s1qd3x1b	321	32	immunoglobulin	immunoglobulin	NN
cord-252230-s1qd3x1b	321	33	production	production	NN
cord-252230-s1qd3x1b	321	34	Diversity	diversity	NN
cord-252230-s1qd3x1b	321	35	in	in	IN
cord-252230-s1qd3x1b	321	36	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	321	37	protein	protein	NN
cord-252230-s1qd3x1b	321	38	secretion	secretion	NN
cord-252230-s1qd3x1b	322	1	Coronaviruses	coronaviruse	NNS
cord-252230-s1qd3x1b	322	2	Hijack	hijack	VBP
cord-252230-s1qd3x1b	322	3	the	the	DT
cord-252230-s1qd3x1b	322	4	LC3-I	lc3-i	NN
cord-252230-s1qd3x1b	322	5	-	-	HYPH
cord-252230-s1qd3x1b	322	6	positive	positive	JJ
cord-252230-s1qd3x1b	322	7	EDEMosomes	edemosome	NNS
cord-252230-s1qd3x1b	322	8	,	,	,
cord-252230-s1qd3x1b	322	9	ER	ER	NNP
cord-252230-s1qd3x1b	322	10	-	-	HYPH
cord-252230-s1qd3x1b	322	11	derived	derive	VBN
cord-252230-s1qd3x1b	322	12	vesicles	vesicle	NNS
cord-252230-s1qd3x1b	322	13	exporting	export	VBG
cord-252230-s1qd3x1b	322	14	short	short	RB
cord-252230-s1qd3x1b	322	15	-	-	HYPH
cord-252230-s1qd3x1b	322	16	lived	live	VBN
cord-252230-s1qd3x1b	322	17	ERAD	ERAD	NNP
cord-252230-s1qd3x1b	322	18	regulators	regulator	NNS
cord-252230-s1qd3x1b	322	19	,	,	,
cord-252230-s1qd3x1b	322	20	for	for	IN
cord-252230-s1qd3x1b	322	21	replication	replication	NN
cord-252230-s1qd3x1b	322	22	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	322	23	proteins	protein	NNS
cord-252230-s1qd3x1b	322	24	stabilize	stabilize	VBP
cord-252230-s1qd3x1b	322	25	pathogen	pathogen	NN
cord-252230-s1qd3x1b	322	26	-	-	HYPH
cord-252230-s1qd3x1b	322	27	containing	contain	VBG
cord-252230-s1qd3x1b	322	28	phagosomes	phagosome	NNS
cord-252230-s1qd3x1b	322	29	for	for	IN
cord-252230-s1qd3x1b	322	30	prolonged	prolong	VBN
cord-252230-s1qd3x1b	322	31	MHC	MHC	NNP
cord-252230-s1qd3x1b	322	32	II	II	NNP
cord-252230-s1qd3x1b	322	33	antigen	antigen	NN
cord-252230-s1qd3x1b	322	34	processing	process	VBG
cord-252230-s1qd3x1b	322	35	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	322	36	-	-	HYPH
cord-252230-s1qd3x1b	322	37	Dependent	dependent	JJ
cord-252230-s1qd3x1b	322	38	Shuttling	shuttle	VBG
cord-252230-s1qd3x1b	322	39	of	of	IN
cord-252230-s1qd3x1b	322	40	TBC1D5	TBC1D5	NNP
cord-252230-s1qd3x1b	322	41	Controls	Controls	NNPS
cord-252230-s1qd3x1b	322	42	Plasma	Plasma	NNP
cord-252230-s1qd3x1b	322	43	Membrane	Membrane	NNP
cord-252230-s1qd3x1b	322	44	Translocation	Translocation	NNP
cord-252230-s1qd3x1b	322	45	of	of	IN
cord-252230-s1qd3x1b	322	46	GLUT1	GLUT1	NNP
cord-252230-s1qd3x1b	322	47	and	and	CC
cord-252230-s1qd3x1b	322	48	Glucose	Glucose	NNP
cord-252230-s1qd3x1b	322	49	Uptake	Uptake	NNP
cord-252230-s1qd3x1b	322	50	Loss	Loss	NNP
cord-252230-s1qd3x1b	322	51	of	of	IN
cord-252230-s1qd3x1b	322	52	the	the	DT
cord-252230-s1qd3x1b	322	53	autophagy	autophagy	NN
cord-252230-s1qd3x1b	322	54	protein	protein	NN
cord-252230-s1qd3x1b	323	1	Atg16L1	Atg16L1	NNP
cord-252230-s1qd3x1b	323	2	enhances	enhance	VBZ
cord-252230-s1qd3x1b	324	1	endotoxin	endotoxin	NN
cord-252230-s1qd3x1b	324	2	-	-	HYPH
cord-252230-s1qd3x1b	324	3	induced	induce	VBN
cord-252230-s1qd3x1b	324	4	IL-1beta	il-1beta	NN
cord-252230-s1qd3x1b	324	5	production	production	NN
cord-252230-s1qd3x1b	324	6	Atg9a	atg9a	NN
cord-252230-s1qd3x1b	324	7	controls	control	VBZ
cord-252230-s1qd3x1b	324	8	dsDNAdriven	dsdnadriven	JJ
cord-252230-s1qd3x1b	324	9	dynamic	dynamic	JJ
cord-252230-s1qd3x1b	324	10	translocation	translocation	NN
cord-252230-s1qd3x1b	324	11	of	of	IN
cord-252230-s1qd3x1b	324	12	STI	STI	NNP
cord-252230-s1qd3x1b	324	13	NG	NG	NNP
cord-252230-s1qd3x1b	324	14	and	and	CC
cord-252230-s1qd3x1b	324	15	the	the	DT
cord-252230-s1qd3x1b	324	16	innate	innate	JJ
cord-252230-s1qd3x1b	324	17	immune	immune	JJ
cord-252230-s1qd3x1b	324	18	response	response	NN
cord-252230-s1qd3x1b	324	19	Toll	Toll	NNP
cord-252230-s1qd3x1b	324	20	-	-	HYPH
cord-252230-s1qd3x1b	324	21	like	like	JJ
cord-252230-s1qd3x1b	324	22	receptor	receptor	NN
cord-252230-s1qd3x1b	324	23	signalling	signal	VBG
cord-252230-s1qd3x1b	324	24	in	in	IN
cord-252230-s1qd3x1b	324	25	macrophages	macrophage	NNS
cord-252230-s1qd3x1b	324	26	links	link	VBZ
cord-252230-s1qd3x1b	324	27	the	the	DT
cord-252230-s1qd3x1b	324	28	autophagy	autophagy	NN
cord-252230-s1qd3x1b	324	29	pathway	pathway	NN
cord-252230-s1qd3x1b	324	30	to	to	IN
cord-252230-s1qd3x1b	325	1	phagocytosis	phagocytosis	NN
cord-252230-s1qd3x1b	325	2	Essential	essential	JJ
cord-252230-s1qd3x1b	325	3	role	role	NN
cord-252230-s1qd3x1b	325	4	for	for	IN
cord-252230-s1qd3x1b	325	5	GAB	GAB	NNP
cord-252230-s1qd3x1b	325	6	ARAP	ARAP	NNP
cord-252230-s1qd3x1b	325	7	autophagy	autophagy	NN
cord-252230-s1qd3x1b	325	8	proteins	protein	NNS
cord-252230-s1qd3x1b	325	9	in	in	IN
cord-252230-s1qd3x1b	325	10	interferon	interferon	NN
cord-252230-s1qd3x1b	325	11	-	-	HYPH
cord-252230-s1qd3x1b	325	12	inducible	inducible	JJ
cord-252230-s1qd3x1b	325	13	GTPase	GTPase	NNP
cord-252230-s1qd3x1b	325	14	-	-	HYPH
cord-252230-s1qd3x1b	325	15	mediated	mediate	VBN
cord-252230-s1qd3x1b	325	16	host	host	NN
cord-252230-s1qd3x1b	325	17	defense	defense	NN
cord-252230-s1qd3x1b	325	18	Antigen	antigen	NN
cord-252230-s1qd3x1b	325	19	-	-	HYPH
cord-252230-s1qd3x1b	325	20	loading	loading	NN
cord-252230-s1qd3x1b	325	21	compartments	compartment	NNS
cord-252230-s1qd3x1b	325	22	for	for	IN
cord-252230-s1qd3x1b	325	23	major	major	JJ
cord-252230-s1qd3x1b	325	24	histocompatibility	histocompatibility	NN
cord-252230-s1qd3x1b	325	25	complex	complex	JJ
cord-252230-s1qd3x1b	325	26	class	class	NN
cord-252230-s1qd3x1b	325	27	II	ii	CD
cord-252230-s1qd3x1b	325	28	molecules	molecule	NNS
cord-252230-s1qd3x1b	325	29	continuously	continuously	RB
cord-252230-s1qd3x1b	325	30	receive	receive	VBP
cord-252230-s1qd3x1b	325	31	input	input	NN
cord-252230-s1qd3x1b	325	32	from	from	IN
cord-252230-s1qd3x1b	325	33	autophagosomes	autophagosomes	NNP
cord-252230-s1qd3x1b	325	34	Identification	Identification	NNP
cord-252230-s1qd3x1b	325	35	and	and	CC
cord-252230-s1qd3x1b	325	36	characterization	characterization	NN
cord-252230-s1qd3x1b	325	37	of	of	IN
cord-252230-s1qd3x1b	325	38	MAVS	MAVS	NNPS
cord-252230-s1qd3x1b	325	39	,	,	,
cord-252230-s1qd3x1b	325	40	a	a	DT
cord-252230-s1qd3x1b	325	41	mitochondrial	mitochondrial	JJ
cord-252230-s1qd3x1b	325	42	antiviral	antiviral	JJ
cord-252230-s1qd3x1b	325	43	signaling	signal	VBG
cord-252230-s1qd3x1b	325	44	protein	protein	NN
cord-252230-s1qd3x1b	325	45	that	that	WDT
cord-252230-s1qd3x1b	325	46	activates	activate	VBZ
cord-252230-s1qd3x1b	325	47	NF	NF	NNP
cord-252230-s1qd3x1b	325	48	-	-	HYPH
cord-252230-s1qd3x1b	325	49	kappaB	kappaB	NNP
cord-252230-s1qd3x1b	325	50	and	and	CC
cord-252230-s1qd3x1b	325	51	IRF	IRF	NNP
cord-252230-s1qd3x1b	325	52	3	3	CD
cord-252230-s1qd3x1b	326	1	The	the	DT
cord-252230-s1qd3x1b	326	2	cell	cell	NN
cord-252230-s1qd3x1b	326	3	biology	biology	NN
cord-252230-s1qd3x1b	326	4	of	of	IN
cord-252230-s1qd3x1b	326	5	inflammasomes	inflammasome	NNS
cord-252230-s1qd3x1b	326	6	:	:	:
cord-252230-s1qd3x1b	326	7	Mechanisms	mechanism	NNS
cord-252230-s1qd3x1b	326	8	of	of	IN
cord-252230-s1qd3x1b	326	9	inflammasome	inflammasome	NN
cord-252230-s1qd3x1b	326	10	activation	activation	NN
cord-252230-s1qd3x1b	326	11	and	and	CC
cord-252230-s1qd3x1b	326	12	regulation	regulation	NN
cord-252230-s1qd3x1b	327	1	Selective	selective	JJ
cord-252230-s1qd3x1b	327	2	subversion	subversion	NN
cord-252230-s1qd3x1b	327	3	of	of	IN
cord-252230-s1qd3x1b	327	4	autophagy	autophagy	NN
cord-252230-s1qd3x1b	327	5	complexes	complex	NNS
cord-252230-s1qd3x1b	327	6	facilitates	facilitate	VBZ
cord-252230-s1qd3x1b	327	7	completion	completion	NN
cord-252230-s1qd3x1b	327	8	of	of	IN
cord-252230-s1qd3x1b	327	9	the	the	DT
cord-252230-s1qd3x1b	327	10	Brucella	Brucella	NNP
cord-252230-s1qd3x1b	327	11	intracellular	intracellular	JJ
cord-252230-s1qd3x1b	327	12	cycle	cycle	NN
cord-252230-s1qd3x1b	327	13	A	a	DT
cord-252230-s1qd3x1b	327	14	global	global	JJ
cord-252230-s1qd3x1b	327	15	analysis	analysis	NN
cord-252230-s1qd3x1b	327	16	of	of	IN
cord-252230-s1qd3x1b	327	17	SNX27-retromer	snx27-retromer	CD
cord-252230-s1qd3x1b	327	18	assembly	assembly	NN
cord-252230-s1qd3x1b	327	19	and	and	CC
cord-252230-s1qd3x1b	327	20	cargo	cargo	NN
cord-252230-s1qd3x1b	327	21	specificity	specificity	NN
cord-252230-s1qd3x1b	327	22	reveals	reveal	VBZ
cord-252230-s1qd3x1b	327	23	a	a	DT
cord-252230-s1qd3x1b	327	24	function	function	NN
cord-252230-s1qd3x1b	327	25	in	in	IN
cord-252230-s1qd3x1b	327	26	glucose	glucose	NN
cord-252230-s1qd3x1b	327	27	and	and	CC
cord-252230-s1qd3x1b	327	28	metal	metal	NN
cord-252230-s1qd3x1b	327	29	ion	ion	NN
cord-252230-s1qd3x1b	327	30	transport	transport	NN
cord-252230-s1qd3x1b	327	31	Cargo	cargo	NN
cord-252230-s1qd3x1b	327	32	recognition	recognition	NN
cord-252230-s1qd3x1b	327	33	and	and	CC
cord-252230-s1qd3x1b	327	34	trafficking	trafficking	NN
cord-252230-s1qd3x1b	327	35	in	in	IN
cord-252230-s1qd3x1b	327	36	selective	selective	JJ
cord-252230-s1qd3x1b	327	37	autophagy	autophagy	NN
cord-252230-s1qd3x1b	327	38	Non	non	JJ
cord-252230-s1qd3x1b	327	39	-	-	JJ
cord-252230-s1qd3x1b	327	40	autophagic	autophagic	JJ
cord-252230-s1qd3x1b	327	41	roles	role	NNS
cord-252230-s1qd3x1b	327	42	of	of	IN
cord-252230-s1qd3x1b	327	43	autophagyrelated	autophagyrelated	JJ
cord-252230-s1qd3x1b	327	44	proteins	protein	NNS
cord-252230-s1qd3x1b	328	1	Cyclic	cyclic	JJ
cord-252230-s1qd3x1b	328	2	GMP	GMP	NNP
cord-252230-s1qd3x1b	328	3	-	-	HYPH
cord-252230-s1qd3x1b	328	4	AMP	AMP	NNP
cord-252230-s1qd3x1b	328	5	synthase	synthase	NN
cord-252230-s1qd3x1b	328	6	is	be	VBZ
cord-252230-s1qd3x1b	328	7	a	a	DT
cord-252230-s1qd3x1b	328	8	cytosolic	cytosolic	JJ
cord-252230-s1qd3x1b	328	9	DNA	dna	NN
cord-252230-s1qd3x1b	328	10	sensor	sensor	NN
cord-252230-s1qd3x1b	328	11	that	that	WDT
cord-252230-s1qd3x1b	328	12	activates	activate	VBZ
cord-252230-s1qd3x1b	328	13	the	the	DT
cord-252230-s1qd3x1b	328	14	type	type	NN
cord-252230-s1qd3x1b	328	15	I	-PRON-	PRP
cord-252230-s1qd3x1b	328	16	interferon	interferon	VBD
cord-252230-s1qd3x1b	328	17	pathway	pathway	NN
cord-252230-s1qd3x1b	328	18	Autophagy	Autophagy	NNP
cord-252230-s1qd3x1b	328	19	in	in	IN
cord-252230-s1qd3x1b	328	20	yeast	yeast	NN
cord-252230-s1qd3x1b	328	21	demonstrated	demonstrate	VBN
cord-252230-s1qd3x1b	328	22	with	with	IN
cord-252230-s1qd3x1b	328	23	proteinase	proteinase	NN
cord-252230-s1qd3x1b	328	24	-	-	HYPH
cord-252230-s1qd3x1b	328	25	deficient	deficient	JJ
cord-252230-s1qd3x1b	328	26	mutants	mutant	NNS
cord-252230-s1qd3x1b	328	27	and	and	CC
cord-252230-s1qd3x1b	328	28	conditions	condition	NNS
cord-252230-s1qd3x1b	328	29	for	for	IN
cord-252230-s1qd3x1b	328	30	its	-PRON-	PRP$
cord-252230-s1qd3x1b	328	31	induction	induction	NN
cord-252230-s1qd3x1b	329	1	Absence	absence	NN
cord-252230-s1qd3x1b	329	2	of	of	IN
cord-252230-s1qd3x1b	329	3	autophagy	autophagy	NN
cord-252230-s1qd3x1b	329	4	results	result	NNS
cord-252230-s1qd3x1b	329	5	in	in	IN
cord-252230-s1qd3x1b	329	6	reactive	reactive	JJ
cord-252230-s1qd3x1b	329	7	oxygen	oxygen	NN
cord-252230-s1qd3x1b	329	8	species	specie	NNS
cord-252230-s1qd3x1b	329	9	-	-	HYPH
cord-252230-s1qd3x1b	329	10	dependent	dependent	JJ
cord-252230-s1qd3x1b	329	11	amplification	amplification	NN
cord-252230-s1qd3x1b	329	12	of	of	IN
cord-252230-s1qd3x1b	329	13	RLR	RLR	NNP
cord-252230-s1qd3x1b	329	14	signaling	signal	VBG
cord-252230-s1qd3x1b	329	15	Role	role	NN
cord-252230-s1qd3x1b	329	16	of	of	IN
cord-252230-s1qd3x1b	329	17	microtubules	microtubule	NNS
cord-252230-s1qd3x1b	329	18	in	in	IN
cord-252230-s1qd3x1b	329	19	extracellular	extracellular	JJ
cord-252230-s1qd3x1b	329	20	release	release	NN
cord-252230-s1qd3x1b	329	21	of	of	IN
cord-252230-s1qd3x1b	329	22	poliovirus	poliovirus	NN
cord-252230-s1qd3x1b	329	23	Isolation	isolation	NN
cord-252230-s1qd3x1b	329	24	of	of	IN
cord-252230-s1qd3x1b	329	25	autophagocytosis	autophagocytosis	NN
cord-252230-s1qd3x1b	329	26	mutants	mutant	NNS
cord-252230-s1qd3x1b	329	27	of	of	IN
cord-252230-s1qd3x1b	329	28	Saccharomyces	saccharomyce	NNS
cord-252230-s1qd3x1b	329	29	cerevisiae	cerevisiae	VBZ
cord-252230-s1qd3x1b	329	30	Defective	defective	JJ
cord-252230-s1qd3x1b	329	31	ATG16L1-mediated	atg16l1-mediated	JJ
cord-252230-s1qd3x1b	329	32	removal	removal	NN
cord-252230-s1qd3x1b	329	33	of	of	IN
cord-252230-s1qd3x1b	329	34	IRE1α	IRE1α	NNS
cord-252230-s1qd3x1b	330	1	drives	drive	VBZ
cord-252230-s1qd3x1b	330	2	Crohn	Crohn	NNP
cord-252230-s1qd3x1b	330	3	's	's	POS
cord-252230-s1qd3x1b	330	4	disease	disease	NN
cord-252230-s1qd3x1b	330	5	-	-	HYPH
cord-252230-s1qd3x1b	330	6	like	like	JJ
cord-252230-s1qd3x1b	330	7	ileitis	ileitis	NNP
cord-252230-s1qd3x1b	331	1	The	the	DT
cord-252230-s1qd3x1b	331	2	ATG	ATG	NNP
cord-252230-s1qd3x1b	331	3	conjugation	conjugation	NN
cord-252230-s1qd3x1b	331	4	systems	system	NNS
cord-252230-s1qd3x1b	331	5	are	be	VBP
cord-252230-s1qd3x1b	331	6	important	important	JJ
cord-252230-s1qd3x1b	331	7	for	for	IN
cord-252230-s1qd3x1b	331	8	degradation	degradation	NN
cord-252230-s1qd3x1b	331	9	of	of	IN
cord-252230-s1qd3x1b	331	10	the	the	DT
cord-252230-s1qd3x1b	331	11	inner	inner	JJ
cord-252230-s1qd3x1b	331	12	autophagosomal	autophagosomal	NN
cord-252230-s1qd3x1b	331	13	membrane	membrane	NN
cord-252230-s1qd3x1b	331	14	Isolation	isolation	NN
cord-252230-s1qd3x1b	331	15	and	and	CC
cord-252230-s1qd3x1b	331	16	characterization	characterization	NN
cord-252230-s1qd3x1b	331	17	of	of	IN
cord-252230-s1qd3x1b	331	18	autophagydefective	autophagydefective	JJ
cord-252230-s1qd3x1b	331	19	mutants	mutant	NNS
cord-252230-s1qd3x1b	331	20	of	of	IN
cord-252230-s1qd3x1b	331	21	Saccharomyces	saccharomyce	NNS
cord-252230-s1qd3x1b	331	22	cerevisiae	cerevisiae	NNS
cord-252230-s1qd3x1b	331	23	B	b	NN
cord-252230-s1qd3x1b	331	24	cell	cell	NN
cord-252230-s1qd3x1b	331	25	autophagy	autophagy	NN
cord-252230-s1qd3x1b	331	26	mediates	mediate	VBZ
cord-252230-s1qd3x1b	331	27	TLR7-dependent	tlr7-dependent	NN
cord-252230-s1qd3x1b	331	28	autoimmunity	autoimmunity	NN
cord-252230-s1qd3x1b	331	29	and	and	CC
cord-252230-s1qd3x1b	331	30	inflammation	inflammation	NN
cord-252230-s1qd3x1b	332	1	Autophagosome	Autophagosome	NNP
cord-252230-s1qd3x1b	332	2	supports	support	VBZ
cord-252230-s1qd3x1b	332	3	coxsackievirus	coxsackievirus	NNP
cord-252230-s1qd3x1b	332	4	B3	b3	NN
cord-252230-s1qd3x1b	332	5	replication	replication	NN
cord-252230-s1qd3x1b	332	6	in	in	IN
cord-252230-s1qd3x1b	332	7	host	host	NN
cord-252230-s1qd3x1b	332	8	cells	cell	NNS
cord-252230-s1qd3x1b	333	1	Cyclic	cyclic	JJ
cord-252230-s1qd3x1b	333	2	GMP	GMP	NNP
cord-252230-s1qd3x1b	333	3	-	-	HYPH
cord-252230-s1qd3x1b	333	4	AMP	AMP	NNP
cord-252230-s1qd3x1b	333	5	is	be	VBZ
cord-252230-s1qd3x1b	333	6	an	an	DT
cord-252230-s1qd3x1b	333	7	endogenous	endogenous	JJ
cord-252230-s1qd3x1b	333	8	second	second	JJ
cord-252230-s1qd3x1b	333	9	messenger	messenger	NN
cord-252230-s1qd3x1b	333	10	in	in	IN
cord-252230-s1qd3x1b	333	11	innate	innate	JJ
cord-252230-s1qd3x1b	333	12	immune	immune	JJ
cord-252230-s1qd3x1b	333	13	signaling	signaling	NN
cord-252230-s1qd3x1b	333	14	by	by	IN
cord-252230-s1qd3x1b	333	15	cytosolic	cytosolic	JJ
cord-252230-s1qd3x1b	333	16	DNA	dna	NN
cord-252230-s1qd3x1b	334	1	The	the	DT
cord-252230-s1qd3x1b	334	2	RNA	RNA	NNP
cord-252230-s1qd3x1b	334	3	helicase	helicase	NN
cord-252230-s1qd3x1b	334	4	RIG	rig	NN
cord-252230-s1qd3x1b	334	5	-	-	:
cord-252230-s1qd3x1b	334	6	I	-PRON-	PRP
cord-252230-s1qd3x1b	334	7	has	have	VBZ
cord-252230-s1qd3x1b	334	8	an	an	DT
cord-252230-s1qd3x1b	334	9	essential	essential	JJ
cord-252230-s1qd3x1b	334	10	function	function	NN
cord-252230-s1qd3x1b	334	11	in	in	IN
cord-252230-s1qd3x1b	334	12	double	double	RB
cord-252230-s1qd3x1b	334	13	-	-	HYPH
cord-252230-s1qd3x1b	334	14	stranded	strand	VBN
cord-252230-s1qd3x1b	334	15	RNA	rna	NN
cord-252230-s1qd3x1b	334	16	-	-	HYPH
cord-252230-s1qd3x1b	334	17	induced	induce	VBN
cord-252230-s1qd3x1b	334	18	innate	innate	JJ
cord-252230-s1qd3x1b	334	19	antiviral	antiviral	JJ
cord-252230-s1qd3x1b	334	20	responses	response	NNS
cord-252230-s1qd3x1b	334	21	Unconventional	unconventional	JJ
cord-252230-s1qd3x1b	334	22	secretion	secretion	NN
cord-252230-s1qd3x1b	334	23	,	,	,
cord-252230-s1qd3x1b	334	24	unconventional	unconventional	JJ
cord-252230-s1qd3x1b	334	25	solutions	solution	NNS
cord-252230-s1qd3x1b	334	26	Translocation	Translocation	NNP
cord-252230-s1qd3x1b	334	27	of	of	IN
cord-252230-s1qd3x1b	334	28	interleukin-1β	interleukin-1β	NNP
cord-252230-s1qd3x1b	334	29	into	into	IN
cord-252230-s1qd3x1b	334	30	a	a	DT
cord-252230-s1qd3x1b	334	31	vesicle	vesicle	NN
cord-252230-s1qd3x1b	334	32	intermediate	intermediate	JJ
cord-252230-s1qd3x1b	334	33	in	in	IN
cord-252230-s1qd3x1b	334	34	autophagy	autophagy	NN
cord-252230-s1qd3x1b	334	35	-	-	HYPH
cord-252230-s1qd3x1b	334	36	mediated	mediate	VBN
cord-252230-s1qd3x1b	334	37	secretion	secretion	NN
cord-252230-s1qd3x1b	334	38	COX5B	COX5B	.
cord-252230-s1qd3x1b	335	1	regulates	regulate	VBZ
cord-252230-s1qd3x1b	335	2	MAVS	MAVS	NNP
cord-252230-s1qd3x1b	335	3	-	-	HYPH
cord-252230-s1qd3x1b	335	4	mediated	mediate	VBN
cord-252230-s1qd3x1b	335	5	antiviral	antiviral	JJ
cord-252230-s1qd3x1b	335	6	signaling	signal	VBG
cord-252230-s1qd3x1b	335	7	through	through	IN
cord-252230-s1qd3x1b	335	8	interaction	interaction	NN
cord-252230-s1qd3x1b	335	9	with	with	IN
cord-252230-s1qd3x1b	335	10	ATG5	ATG5	NNP
cord-252230-s1qd3x1b	335	11	and	and	CC
cord-252230-s1qd3x1b	335	12	repressing	repress	VBG
cord-252230-s1qd3x1b	336	1	ROS	ROS	NNP
cord-252230-s1qd3x1b	336	2	production	production	NN
cord-252230-s1qd3x1b	336	3	NF	nf	NN
cord-252230-s1qd3x1b	336	4	-	-	HYPH
cord-252230-s1qd3x1b	336	5	κB	κB	NNP
cord-252230-s1qd3x1b	336	6	Restricts	restrict	VBZ
cord-252230-s1qd3x1b	336	7	Inflammasome	Inflammasome	NNP
cord-252230-s1qd3x1b	336	8	Activation	Activation	NNP
cord-252230-s1qd3x1b	336	9	via	via	IN
cord-252230-s1qd3x1b	336	10	Elimination	elimination	NN
cord-252230-s1qd3x1b	336	11	of	of	IN
cord-252230-s1qd3x1b	336	12	Damaged	Damaged	NNP
cord-252230-s1qd3x1b	336	13	Mitochondria	Mitochondria	NNPS
cord-252230-s1qd3x1b	336	14	Grant	Grant	NNP
cord-252230-s1qd3x1b	336	15	support	support	NN
cord-252230-s1qd3x1b	336	16	includes	include	VBZ
cord-252230-s1qd3x1b	336	17	the	the	DT
cord-252230-s1qd3x1b	336	18	National	National	NNP
cord-252230-s1qd3x1b	336	19	Institutes	Institutes	NNPS
cord-252230-s1qd3x1b	336	20	of	of	IN
cord-252230-s1qd3x1b	336	21	Health	Health	NNP
cord-252230-s1qd3x1b	336	22	(	(	-LRB-
cord-252230-s1qd3x1b	336	23	CA126792	CA126792	NNP
cord-252230-s1qd3x1b	336	24	,	,	,
cord-252230-s1qd3x1b	336	25	CA201849	CA201849	NNP
cord-252230-s1qd3x1b	336	26	,	,	,
cord-252230-s1qd3x1b	336	27	CA188404	CA188404	NNP
cord-252230-s1qd3x1b	336	28	,	,	,
cord-252230-s1qd3x1b	336	29	and	and	CC
cord-252230-s1qd3x1b	336	30	AG057462	AG057462	NNS
cord-252230-s1qd3x1b	336	31	to	to	IN
cord-252230-s1qd3x1b	336	32	J.	J.	NNP
cord-252230-s1qd3x1b	336	33	Debnath	Debnath	NNP
cord-252230-s1qd3x1b	336	34	,	,	,
cord-252230-s1qd3x1b	336	35	and	and	CC
cord-252230-s1qd3x1b	336	36	HL123340	HL123340	NNP
cord-252230-s1qd3x1b	336	37	,	,	,
cord-252230-s1qd3x1b	336	38	DK093668	dk093668	UH
cord-252230-s1qd3x1b	336	39	,	,	,
cord-252230-s1qd3x1b	336	40	DK103788	DK103788	NNP
cord-252230-s1qd3x1b	336	41	,	,	,
cord-252230-s1qd3x1b	336	42	and	and	CC
cord-252230-s1qd3x1b	336	43	AI121244	ai121244	NN
cord-252230-s1qd3x1b	336	44	to	to	IN
cord-252230-s1qd3x1b	336	45	K.	K.	NNP
cord-252230-s1qd3x1b	336	46	Cadwell	Cadwell	NNP
cord-252230-s1qd3x1b	336	47	 	 	_SP