id sid tid token lemma pos cord-254317-n2knqj4z 1 1 key key JJ cord-254317-n2knqj4z 1 2 : : : cord-254317-n2knqj4z 1 3 cord-254317-n2knqj4z cord-254317-n2knqj4z VBN cord-254317-n2knqj4z 1 4 authors author NNS cord-254317-n2knqj4z 1 5 : : : cord-254317-n2knqj4z 1 6 Su Su NNP cord-254317-n2knqj4z 1 7 , , , cord-254317-n2knqj4z 1 8 Yunfang Yunfang NNP cord-254317-n2knqj4z 1 9 ; ; : cord-254317-n2knqj4z 1 10 Hou Hou NNP cord-254317-n2knqj4z 1 11 , , , cord-254317-n2knqj4z 1 12 Yixuan Yixuan NNP cord-254317-n2knqj4z 1 13 ; ; : cord-254317-n2knqj4z 1 14 Wang Wang NNP cord-254317-n2knqj4z 1 15 , , , cord-254317-n2knqj4z 2 1 Qiuhong Qiuhong NNP cord-254317-n2knqj4z 2 2 title title NN cord-254317-n2knqj4z 2 3 : : : cord-254317-n2knqj4z 3 1 The the DT cord-254317-n2knqj4z 3 2 enhanced enhanced JJ cord-254317-n2knqj4z 3 3 replication replication NN cord-254317-n2knqj4z 3 4 of of IN cord-254317-n2knqj4z 3 5 an an DT cord-254317-n2knqj4z 3 6 S s NN cord-254317-n2knqj4z 3 7 - - HYPH cord-254317-n2knqj4z 3 8 intact intact JJ cord-254317-n2knqj4z 3 9 PEDV PEDV NNP cord-254317-n2knqj4z 3 10 during during IN cord-254317-n2knqj4z 3 11 coinfection coinfection NN cord-254317-n2knqj4z 3 12 with with IN cord-254317-n2knqj4z 3 13 an an DT cord-254317-n2knqj4z 3 14 S1 S1 NNP cord-254317-n2knqj4z 3 15 NTD NTD NNP cord-254317-n2knqj4z 3 16 - - HYPH cord-254317-n2knqj4z 3 17 del del NNP cord-254317-n2knqj4z 3 18 PEDV PEDV NNP cord-254317-n2knqj4z 3 19 in in IN cord-254317-n2knqj4z 3 20 piglets piglet NNS cord-254317-n2knqj4z 3 21 date date NN cord-254317-n2knqj4z 3 22 : : : cord-254317-n2knqj4z 3 23 2018 2018 CD cord-254317-n2knqj4z 3 24 - - HYPH cord-254317-n2knqj4z 3 25 11 11 CD cord-254317-n2knqj4z 3 26 - - SYM cord-254317-n2knqj4z 3 27 27 27 CD cord-254317-n2knqj4z 3 28 journal journal NN cord-254317-n2knqj4z 3 29 : : : cord-254317-n2knqj4z 4 1 Vet Vet NNP cord-254317-n2knqj4z 4 2 Microbiol Microbiol NNP cord-254317-n2knqj4z 4 3 DOI DOI NNP cord-254317-n2knqj4z 4 4 : : : cord-254317-n2knqj4z 4 5 10.1016/ 10.1016/ CD cord-254317-n2knqj4z 5 1 j.vetmic.2018.11.025 j.vetmic.2018.11.025 IN cord-254317-n2knqj4z 5 2 sha sha XX cord-254317-n2knqj4z 5 3 : : : cord-254317-n2knqj4z 6 1 30487cd3a38587e8854be79b70b7205d7dac54fb 30487cd3a38587e8854be79b70b7205d7dac54fb CD cord-254317-n2knqj4z 6 2 doc_id doc_id CD cord-254317-n2knqj4z 6 3 : : : cord-254317-n2knqj4z 6 4 254317 254317 CD cord-254317-n2knqj4z 6 5 cord_uid cord_uid NNS cord-254317-n2knqj4z 6 6 : : : cord-254317-n2knqj4z 7 1 n2knqj4z n2knqj4z NNP cord-254317-n2knqj4z 7 2 Porcine Porcine NNP cord-254317-n2knqj4z 7 3 epidemic epidemic NN cord-254317-n2knqj4z 7 4 diarrhea diarrhea NN cord-254317-n2knqj4z 7 5 virus virus NN cord-254317-n2knqj4z 7 6 ( ( -LRB- cord-254317-n2knqj4z 7 7 PEDV PEDV NNP cord-254317-n2knqj4z 7 8 ) ) -RRB- cord-254317-n2knqj4z 7 9 variants variant NNS cord-254317-n2knqj4z 7 10 having have VBG cord-254317-n2knqj4z 7 11 a a DT cord-254317-n2knqj4z 7 12 large large JJ cord-254317-n2knqj4z 7 13 deletion deletion NN cord-254317-n2knqj4z 7 14 in in IN cord-254317-n2knqj4z 7 15 the the DT cord-254317-n2knqj4z 7 16 N n CD cord-254317-n2knqj4z 7 17 - - HYPH cord-254317-n2knqj4z 7 18 terminal terminal NN cord-254317-n2knqj4z 7 19 domain domain NN cord-254317-n2knqj4z 7 20 of of IN cord-254317-n2knqj4z 7 21 the the DT cord-254317-n2knqj4z 7 22 S1 S1 NNP cord-254317-n2knqj4z 7 23 subunit subunit NN cord-254317-n2knqj4z 7 24 of of IN cord-254317-n2knqj4z 7 25 spike spike NN cord-254317-n2knqj4z 7 26 ( ( -LRB- cord-254317-n2knqj4z 7 27 S s NN cord-254317-n2knqj4z 7 28 ) ) -RRB- cord-254317-n2knqj4z 7 29 protein protein NN cord-254317-n2knqj4z 7 30 were be VBD cord-254317-n2knqj4z 7 31 designated designate VBN cord-254317-n2knqj4z 7 32 as as IN cord-254317-n2knqj4z 7 33 S1 S1 NNP cord-254317-n2knqj4z 7 34 NTD NTD NNP cord-254317-n2knqj4z 7 35 - - HYPH cord-254317-n2knqj4z 7 36 del del NNP cord-254317-n2knqj4z 7 37 PEDVs pedv NNS cord-254317-n2knqj4z 7 38 . . . cord-254317-n2knqj4z 8 1 They -PRON- PRP cord-254317-n2knqj4z 8 2 replicate replicate VBP cord-254317-n2knqj4z 8 3 well well RB cord-254317-n2knqj4z 8 4 in in IN cord-254317-n2knqj4z 8 5 experimentally experimentally RB cord-254317-n2knqj4z 8 6 infected infect VBN cord-254317-n2knqj4z 8 7 pigs pig NNS cord-254317-n2knqj4z 8 8 . . . cord-254317-n2knqj4z 9 1 However however RB cord-254317-n2knqj4z 9 2 , , , cord-254317-n2knqj4z 9 3 on on IN cord-254317-n2knqj4z 9 4 farms farm NNS cord-254317-n2knqj4z 9 5 they -PRON- PRP cord-254317-n2knqj4z 9 6 often often RB cord-254317-n2knqj4z 9 7 co co VBP cord-254317-n2knqj4z 9 8 - - VB cord-254317-n2knqj4z 9 9 infect infect VB cord-254317-n2knqj4z 9 10 pigs pig NNS cord-254317-n2knqj4z 9 11 with with IN cord-254317-n2knqj4z 9 12 the the DT cord-254317-n2knqj4z 9 13 PEDV PEDV NNP cord-254317-n2knqj4z 9 14 containing contain VBG cord-254317-n2knqj4z 9 15 an an DT cord-254317-n2knqj4z 9 16 intact intact JJ cord-254317-n2knqj4z 9 17 S s NN cord-254317-n2knqj4z 9 18 protein protein NN cord-254317-n2knqj4z 9 19 ( ( -LRB- cord-254317-n2knqj4z 9 20 S s NN cord-254317-n2knqj4z 9 21 - - HYPH cord-254317-n2knqj4z 9 22 intact intact JJ cord-254317-n2knqj4z 9 23 PEDV PEDV NNP cord-254317-n2knqj4z 9 24 ) ) -RRB- cord-254317-n2knqj4z 9 25 . . . cord-254317-n2knqj4z 10 1 We -PRON- PRP cord-254317-n2knqj4z 10 2 aimed aim VBD cord-254317-n2knqj4z 10 3 to to TO cord-254317-n2knqj4z 10 4 characterize characterize VB cord-254317-n2knqj4z 10 5 viral viral JJ cord-254317-n2knqj4z 10 6 replication replication NN cord-254317-n2knqj4z 10 7 and and CC cord-254317-n2knqj4z 10 8 pathogenesis pathogenesis NN cord-254317-n2knqj4z 10 9 in in IN cord-254317-n2knqj4z 10 10 neonatal neonatal JJ cord-254317-n2knqj4z 10 11 gnotobiotic gnotobiotic JJ cord-254317-n2knqj4z 10 12 pigs pig NNS cord-254317-n2knqj4z 10 13 infected infect VBN cord-254317-n2knqj4z 10 14 simultaneously simultaneously RB cord-254317-n2knqj4z 10 15 with with IN cord-254317-n2knqj4z 10 16 the the DT cord-254317-n2knqj4z 10 17 two two CD cord-254317-n2knqj4z 10 18 types type NNS cord-254317-n2knqj4z 10 19 of of IN cord-254317-n2knqj4z 10 20 PEDV PEDV NNP cord-254317-n2knqj4z 10 21 using use VBG cord-254317-n2knqj4z 10 22 two two CD cord-254317-n2knqj4z 10 23 recombinant recombinant JJ cord-254317-n2knqj4z 10 24 PEDVs pedv NNS cord-254317-n2knqj4z 10 25 : : : cord-254317-n2knqj4z 10 26 icPC22A icpc22a CD cord-254317-n2knqj4z 10 27 and and CC cord-254317-n2knqj4z 10 28 its -PRON- PRP$ cord-254317-n2knqj4z 10 29 S1 S1 NNP cord-254317-n2knqj4z 10 30 NTD NTD NNP cord-254317-n2knqj4z 10 31 - - HYPH cord-254317-n2knqj4z 10 32 del del NNP cord-254317-n2knqj4z 10 33 form form NN cord-254317-n2knqj4z 10 34 icPC22A icPC22A NNP cord-254317-n2knqj4z 10 35 - - HYPH cord-254317-n2knqj4z 10 36 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 10 37 . . . cord-254317-n2knqj4z 11 1 Additionally additionally RB cord-254317-n2knqj4z 11 2 , , , cord-254317-n2knqj4z 11 3 viral viral JJ cord-254317-n2knqj4z 11 4 replication replication NN cord-254317-n2knqj4z 11 5 was be VBD cord-254317-n2knqj4z 11 6 compared compare VBN cord-254317-n2knqj4z 11 7 in in IN cord-254317-n2knqj4z 11 8 Vero Vero NNP cord-254317-n2knqj4z 11 9 and and CC cord-254317-n2knqj4z 11 10 IPEC IPEC NNP cord-254317-n2knqj4z 11 11 - - HYPH cord-254317-n2knqj4z 11 12 DQ dq NN cord-254317-n2knqj4z 11 13 cells cell NNS cord-254317-n2knqj4z 11 14 at at IN cord-254317-n2knqj4z 11 15 the the DT cord-254317-n2knqj4z 11 16 presence presence NN cord-254317-n2knqj4z 11 17 of of IN cord-254317-n2knqj4z 11 18 bovine bovine JJ cord-254317-n2knqj4z 11 19 mucin mucin NN cord-254317-n2knqj4z 11 20 ( ( -LRB- cord-254317-n2knqj4z 11 21 BM BM NNP cord-254317-n2knqj4z 11 22 ) ) -RRB- cord-254317-n2knqj4z 11 23 , , , cord-254317-n2knqj4z 11 24 porcine porcine JJ cord-254317-n2knqj4z 11 25 gastric gastric JJ cord-254317-n2knqj4z 11 26 mucin mucin NN cord-254317-n2knqj4z 11 27 ( ( -LRB- cord-254317-n2knqj4z 11 28 PGM PGM NNP cord-254317-n2knqj4z 11 29 ) ) -RRB- cord-254317-n2knqj4z 11 30 , , , cord-254317-n2knqj4z 11 31 swine swine NN cord-254317-n2knqj4z 11 32 bile bile NN cord-254317-n2knqj4z 11 33 and and CC cord-254317-n2knqj4z 11 34 bile bile NN cord-254317-n2knqj4z 11 35 acids acid NNS cord-254317-n2knqj4z 11 36 during during IN cord-254317-n2knqj4z 11 37 inoculation inoculation NN cord-254317-n2knqj4z 11 38 . . . cord-254317-n2knqj4z 12 1 In in IN cord-254317-n2knqj4z 12 2 the the DT cord-254317-n2knqj4z 12 3 pigs pig NNS cord-254317-n2knqj4z 12 4 coinfected coinfecte VBD cord-254317-n2knqj4z 12 5 with with IN cord-254317-n2knqj4z 12 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 12 7 and and CC cord-254317-n2knqj4z 12 8 icPC22A icPC22A NNP cord-254317-n2knqj4z 12 9 - - HYPH cord-254317-n2knqj4z 12 10 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 12 11 , , , cord-254317-n2knqj4z 12 12 icPC22A icPC22A NNP cord-254317-n2knqj4z 12 13 replicated replicate VBD cord-254317-n2knqj4z 12 14 to to IN cord-254317-n2knqj4z 12 15 a a DT cord-254317-n2knqj4z 12 16 higher high JJR cord-254317-n2knqj4z 12 17 peak peak NN cord-254317-n2knqj4z 12 18 titer titer NN cord-254317-n2knqj4z 12 19 than than IN cord-254317-n2knqj4z 12 20 its -PRON- PRP$ cord-254317-n2knqj4z 12 21 infection infection NN cord-254317-n2knqj4z 12 22 of of IN cord-254317-n2knqj4z 12 23 pigs pig NNS cord-254317-n2knqj4z 12 24 without without IN cord-254317-n2knqj4z 12 25 the the DT cord-254317-n2knqj4z 12 26 presence presence NN cord-254317-n2knqj4z 12 27 of of IN cord-254317-n2knqj4z 12 28 icPC22A icPC22A NNP cord-254317-n2knqj4z 12 29 - - HYPH cord-254317-n2knqj4z 12 30 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 12 31 . . . cord-254317-n2knqj4z 13 1 The the DT cord-254317-n2knqj4z 13 2 severity severity NN cord-254317-n2knqj4z 13 3 of of IN cord-254317-n2knqj4z 13 4 diarrhea diarrhea NN cord-254317-n2knqj4z 13 5 and and CC cord-254317-n2knqj4z 13 6 intestinal intestinal JJ cord-254317-n2knqj4z 13 7 atrophy atrophy NN cord-254317-n2knqj4z 13 8 were be VBD cord-254317-n2knqj4z 13 9 similar similar JJ cord-254317-n2knqj4z 13 10 between between IN cord-254317-n2knqj4z 13 11 icPC22A icPC22A NNP cord-254317-n2knqj4z 13 12 and and CC cord-254317-n2knqj4z 13 13 the the DT cord-254317-n2knqj4z 13 14 coinfection coinfection NN cord-254317-n2knqj4z 13 15 groups group NNS cord-254317-n2knqj4z 13 16 , , , cord-254317-n2knqj4z 13 17 but but CC cord-254317-n2knqj4z 13 18 were be VBD cord-254317-n2knqj4z 13 19 significantly significantly RB cord-254317-n2knqj4z 13 20 higher high JJR cord-254317-n2knqj4z 13 21 than than IN cord-254317-n2knqj4z 13 22 icPC22A icPC22A NNP cord-254317-n2knqj4z 13 23 - - HYPH cord-254317-n2knqj4z 13 24 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 13 25 group group NN cord-254317-n2knqj4z 13 26 . . . cord-254317-n2knqj4z 14 1 In in IN cord-254317-n2knqj4z 14 2 Vero Vero NNP cord-254317-n2knqj4z 14 3 and and CC cord-254317-n2knqj4z 14 4 IPEC IPEC NNP cord-254317-n2knqj4z 14 5 - - HYPH cord-254317-n2knqj4z 14 6 DQ dq NN cord-254317-n2knqj4z 14 7 cells cell NNS cord-254317-n2knqj4z 14 8 , , , cord-254317-n2knqj4z 14 9 certain certain JJ cord-254317-n2knqj4z 14 10 concentrations concentration NNS cord-254317-n2knqj4z 14 11 of of IN cord-254317-n2knqj4z 14 12 BM BM NNP cord-254317-n2knqj4z 14 13 , , , cord-254317-n2knqj4z 14 14 PGM PGM NNP cord-254317-n2knqj4z 14 15 , , , cord-254317-n2knqj4z 14 16 bile bile NN cord-254317-n2knqj4z 14 17 and and CC cord-254317-n2knqj4z 14 18 bile bile NN cord-254317-n2knqj4z 14 19 acids acid NNS cord-254317-n2knqj4z 14 20 increased increase VBD cord-254317-n2knqj4z 14 21 significantly significantly RB cord-254317-n2knqj4z 14 22 the the DT cord-254317-n2knqj4z 14 23 infectivity infectivity NN cord-254317-n2knqj4z 14 24 of of IN cord-254317-n2knqj4z 14 25 icPC22A icPC22A NNP cord-254317-n2knqj4z 14 26 but but CC cord-254317-n2knqj4z 14 27 had have VBD cord-254317-n2knqj4z 14 28 no no DT cord-254317-n2knqj4z 14 29 or or CC cord-254317-n2knqj4z 14 30 negative negative JJ cord-254317-n2knqj4z 14 31 effects effect NNS cord-254317-n2knqj4z 14 32 on on IN cord-254317-n2knqj4z 14 33 icPC22A icPC22A NNP cord-254317-n2knqj4z 14 34 - - HYPH cord-254317-n2knqj4z 14 35 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 14 36 . . . cord-254317-n2knqj4z 15 1 These these DT cord-254317-n2knqj4z 15 2 results result NNS cord-254317-n2knqj4z 15 3 indicated indicate VBD cord-254317-n2knqj4z 15 4 that that IN cord-254317-n2knqj4z 15 5 the the DT cord-254317-n2knqj4z 15 6 replication replication NN cord-254317-n2knqj4z 15 7 of of IN cord-254317-n2knqj4z 15 8 the the DT cord-254317-n2knqj4z 15 9 S s NN cord-254317-n2knqj4z 15 10 - - HYPH cord-254317-n2knqj4z 15 11 intact intact JJ cord-254317-n2knqj4z 15 12 PEDV PEDV NNP cord-254317-n2knqj4z 15 13 was be VBD cord-254317-n2knqj4z 15 14 enhanced enhance VBN cord-254317-n2knqj4z 15 15 during during IN cord-254317-n2knqj4z 15 16 coinfection coinfection NN cord-254317-n2knqj4z 15 17 in in IN cord-254317-n2knqj4z 15 18 piglets piglet NNS cord-254317-n2knqj4z 15 19 . . . cord-254317-n2knqj4z 16 1 This this DT cord-254317-n2knqj4z 16 2 observation observation NN cord-254317-n2knqj4z 16 3 may may MD cord-254317-n2knqj4z 16 4 be be VB cord-254317-n2knqj4z 16 5 explained explain VBN cord-254317-n2knqj4z 16 6 partially partially RB cord-254317-n2knqj4z 16 7 by by IN cord-254317-n2knqj4z 16 8 the the DT cord-254317-n2knqj4z 16 9 fact fact NN cord-254317-n2knqj4z 16 10 that that IN cord-254317-n2knqj4z 16 11 mucin mucin NN cord-254317-n2knqj4z 16 12 , , , cord-254317-n2knqj4z 16 13 bile bile NN cord-254317-n2knqj4z 16 14 and and CC cord-254317-n2knqj4z 16 15 bile bile NN cord-254317-n2knqj4z 16 16 acids acid NNS cord-254317-n2knqj4z 16 17 in in IN cord-254317-n2knqj4z 16 18 gastrointestinal gastrointestinal JJ cord-254317-n2knqj4z 16 19 tract tract NN cord-254317-n2knqj4z 16 20 had have VBD cord-254317-n2knqj4z 16 21 facilitating facilitate VBG cord-254317-n2knqj4z 16 22 effects effect NNS cord-254317-n2knqj4z 16 23 on on IN cord-254317-n2knqj4z 16 24 the the DT cord-254317-n2knqj4z 16 25 infection infection NN cord-254317-n2knqj4z 16 26 of of IN cord-254317-n2knqj4z 16 27 S s NN cord-254317-n2knqj4z 16 28 - - HYPH cord-254317-n2knqj4z 16 29 intact intact JJ cord-254317-n2knqj4z 16 30 PEDV PEDV NNP cord-254317-n2knqj4z 16 31 , , , cord-254317-n2knqj4z 16 32 but but CC cord-254317-n2knqj4z 16 33 no no DT cord-254317-n2knqj4z 16 34 / / SYM cord-254317-n2knqj4z 16 35 inhibition inhibition NN cord-254317-n2knqj4z 16 36 effects effect NNS cord-254317-n2knqj4z 16 37 on on IN cord-254317-n2knqj4z 16 38 S1 S1 NNP cord-254317-n2knqj4z 16 39 NTD NTD NNP cord-254317-n2knqj4z 16 40 - - HYPH cord-254317-n2knqj4z 16 41 del del NNP cord-254317-n2knqj4z 16 42 PEDV PEDV NNP cord-254317-n2knqj4z 16 43 . . . cord-254317-n2knqj4z 17 1 Porcine porcine JJ cord-254317-n2knqj4z 17 2 epidemic epidemic NN cord-254317-n2knqj4z 17 3 diarrhea diarrhea NN cord-254317-n2knqj4z 17 4 virus virus NN cord-254317-n2knqj4z 17 5 ( ( -LRB- cord-254317-n2knqj4z 17 6 PEDV PEDV NNP cord-254317-n2knqj4z 17 7 ) ) -RRB- cord-254317-n2knqj4z 17 8 belongs belong VBZ cord-254317-n2knqj4z 17 9 to to IN cord-254317-n2knqj4z 17 10 the the DT cord-254317-n2knqj4z 17 11 genus genus NN cord-254317-n2knqj4z 17 12 Alphacoronavirus Alphacoronavirus NNP cord-254317-n2knqj4z 17 13 in in IN cord-254317-n2knqj4z 17 14 the the DT cord-254317-n2knqj4z 17 15 family family NN cord-254317-n2knqj4z 17 16 Coronaviridae Coronaviridae NNP cord-254317-n2knqj4z 17 17 . . . cord-254317-n2knqj4z 18 1 It -PRON- PRP cord-254317-n2knqj4z 18 2 causes cause VBZ cord-254317-n2knqj4z 18 3 severe severe JJ cord-254317-n2knqj4z 18 4 gastroenteritis gastroenteritis NN cord-254317-n2knqj4z 18 5 in in IN cord-254317-n2knqj4z 18 6 neonatal neonatal JJ cord-254317-n2knqj4z 18 7 pigs pig NNS cord-254317-n2knqj4z 18 8 worldwide worldwide RB cord-254317-n2knqj4z 18 9 . . . cord-254317-n2knqj4z 19 1 The the DT cord-254317-n2knqj4z 19 2 genome genome NN cord-254317-n2knqj4z 19 3 size size NN cord-254317-n2knqj4z 19 4 of of IN cord-254317-n2knqj4z 19 5 PEDV PEDV NNP cord-254317-n2knqj4z 19 6 is be VBZ cord-254317-n2knqj4z 19 7 28 28 CD cord-254317-n2knqj4z 19 8 kb kb NNP cord-254317-n2knqj4z 19 9 . . . cord-254317-n2knqj4z 20 1 It -PRON- PRP cord-254317-n2knqj4z 20 2 contains contain VBZ cord-254317-n2knqj4z 20 3 ORF1a ORF1a NNP cord-254317-n2knqj4z 20 4 and and CC cord-254317-n2knqj4z 20 5 ORF1b ORF1b NNP cord-254317-n2knqj4z 20 6 encoding encode VBG cord-254317-n2knqj4z 20 7 14 14 CD cord-254317-n2knqj4z 20 8 - - SYM cord-254317-n2knqj4z 20 9 16 16 CD cord-254317-n2knqj4z 20 10 non non JJ cord-254317-n2knqj4z 20 11 - - JJ cord-254317-n2knqj4z 20 12 structural structural JJ cord-254317-n2knqj4z 20 13 proteins protein NNS cord-254317-n2knqj4z 20 14 , , , cord-254317-n2knqj4z 20 15 an an DT cord-254317-n2knqj4z 20 16 ORF3 ORF3 NNP cord-254317-n2knqj4z 20 17 encoding encode VBG cord-254317-n2knqj4z 20 18 an an DT cord-254317-n2knqj4z 20 19 accessory accessory NN cord-254317-n2knqj4z 20 20 protein protein NN cord-254317-n2knqj4z 20 21 , , , cord-254317-n2knqj4z 20 22 and and CC cord-254317-n2knqj4z 20 23 four four CD cord-254317-n2knqj4z 20 24 ORFs orfs NN cord-254317-n2knqj4z 20 25 encoding encode VBG cord-254317-n2knqj4z 20 26 structural structural JJ cord-254317-n2knqj4z 20 27 proteins protein NNS cord-254317-n2knqj4z 20 28 : : : cord-254317-n2knqj4z 20 29 spike spike NN cord-254317-n2knqj4z 20 30 ( ( -LRB- cord-254317-n2knqj4z 20 31 S S NNP cord-254317-n2knqj4z 20 32 ) ) -RRB- cord-254317-n2knqj4z 20 33 , , , cord-254317-n2knqj4z 20 34 membrane membrane NN cord-254317-n2knqj4z 20 35 ( ( -LRB- cord-254317-n2knqj4z 20 36 M M NNP cord-254317-n2knqj4z 20 37 ) ) -RRB- cord-254317-n2knqj4z 20 38 , , , cord-254317-n2knqj4z 20 39 envelop envelop NNP cord-254317-n2knqj4z 20 40 ( ( -LRB- cord-254317-n2knqj4z 20 41 E E NNP cord-254317-n2knqj4z 20 42 ) ) -RRB- cord-254317-n2knqj4z 20 43 , , , cord-254317-n2knqj4z 20 44 and and CC cord-254317-n2knqj4z 20 45 nucleocapsid nucleocapsid NN cord-254317-n2knqj4z 20 46 ( ( -LRB- cord-254317-n2knqj4z 20 47 N N NNP cord-254317-n2knqj4z 20 48 ) ) -RRB- cord-254317-n2knqj4z 20 49 proteins protein NNS cord-254317-n2knqj4z 20 50 . . . cord-254317-n2knqj4z 21 1 PEDV PEDV NNP cord-254317-n2knqj4z 21 2 S S NNP cord-254317-n2knqj4z 21 3 protein protein NN cord-254317-n2knqj4z 21 4 mediates mediate VBZ cord-254317-n2knqj4z 21 5 the the DT cord-254317-n2knqj4z 21 6 essential essential JJ cord-254317-n2knqj4z 21 7 functions function NNS cord-254317-n2knqj4z 21 8 of of IN cord-254317-n2knqj4z 21 9 receptor receptor NN cord-254317-n2knqj4z 21 10 binding binding NN cord-254317-n2knqj4z 21 11 ( ( -LRB- cord-254317-n2knqj4z 21 12 via via IN cord-254317-n2knqj4z 21 13 S1 s1 NN cord-254317-n2knqj4z 21 14 subunit subunit NN cord-254317-n2knqj4z 21 15 ) ) -RRB- cord-254317-n2knqj4z 21 16 and and CC cord-254317-n2knqj4z 21 17 subsequent subsequent JJ cord-254317-n2knqj4z 21 18 fusion fusion NN cord-254317-n2knqj4z 21 19 of of IN cord-254317-n2knqj4z 21 20 the the DT cord-254317-n2knqj4z 21 21 viral viral JJ cord-254317-n2knqj4z 21 22 and and CC cord-254317-n2knqj4z 21 23 cellular cellular JJ cord-254317-n2knqj4z 21 24 membranes membrane NNS cord-254317-n2knqj4z 21 25 ( ( -LRB- cord-254317-n2knqj4z 21 26 via via IN cord-254317-n2knqj4z 21 27 S2 S2 NNP cord-254317-n2knqj4z 21 28 subunit subunit NN cord-254317-n2knqj4z 21 29 ) ) -RRB- cord-254317-n2knqj4z 22 1 ( ( -LRB- cord-254317-n2knqj4z 22 2 Li Li NNP cord-254317-n2knqj4z 22 3 , , , cord-254317-n2knqj4z 22 4 2016 2016 CD cord-254317-n2knqj4z 22 5 ) ) -RRB- cord-254317-n2knqj4z 22 6 . . . cord-254317-n2knqj4z 23 1 S1 s1 NN cord-254317-n2knqj4z 23 2 subunit subunit NN cord-254317-n2knqj4z 23 3 contains contain VBZ cord-254317-n2knqj4z 23 4 two two CD cord-254317-n2knqj4z 23 5 domains domain NNS cord-254317-n2knqj4z 23 6 , , , cord-254317-n2knqj4z 23 7 the the DT cord-254317-n2knqj4z 23 8 N n CD cord-254317-n2knqj4z 23 9 - - HYPH cord-254317-n2knqj4z 23 10 terminal terminal NN cord-254317-n2knqj4z 23 11 domain domain NN cord-254317-n2knqj4z 23 12 ( ( -LRB- cord-254317-n2knqj4z 23 13 S1 S1 NNP cord-254317-n2knqj4z 23 14 NTD NTD NNP cord-254317-n2knqj4z 23 15 , , , cord-254317-n2knqj4z 23 16 residues residue NNS cord-254317-n2knqj4z 23 17 21 21 CD cord-254317-n2knqj4z 23 18 - - SYM cord-254317-n2knqj4z 23 19 324 324 CD cord-254317-n2knqj4z 23 20 based base VBN cord-254317-n2knqj4z 23 21 on on IN cord-254317-n2knqj4z 23 22 PEDV PEDV NNP cord-254317-n2knqj4z 23 23 CV777 CV777 NNP cord-254317-n2knqj4z 23 24 ) ) -RRB- cord-254317-n2knqj4z 23 25 and and CC cord-254317-n2knqj4z 23 26 the the DT cord-254317-n2knqj4z 23 27 C C NNP cord-254317-n2knqj4z 23 28 - - HYPH cord-254317-n2knqj4z 23 29 terminal terminal NN cord-254317-n2knqj4z 23 30 domain domain NN cord-254317-n2knqj4z 23 31 ( ( -LRB- cord-254317-n2knqj4z 23 32 S1 S1 NNP cord-254317-n2knqj4z 23 33 CTD CTD NNP cord-254317-n2knqj4z 23 34 , , , cord-254317-n2knqj4z 23 35 residues residue VBZ cord-254317-n2knqj4z 23 36 253 253 CD cord-254317-n2knqj4z 23 37 - - HYPH cord-254317-n2knqj4z 23 38 638 638 CD cord-254317-n2knqj4z 23 39 ) ) -RRB- cord-254317-n2knqj4z 23 40 . . . cord-254317-n2knqj4z 24 1 However however RB cord-254317-n2knqj4z 24 2 , , , cord-254317-n2knqj4z 24 3 the the DT cord-254317-n2knqj4z 24 4 cellular cellular JJ cord-254317-n2knqj4z 24 5 receptor receptor NN cord-254317-n2knqj4z 24 6 of of IN cord-254317-n2knqj4z 24 7 PEDV PEDV NNP cord-254317-n2knqj4z 24 8 is be VBZ cord-254317-n2knqj4z 24 9 still still RB cord-254317-n2knqj4z 24 10 unknown unknown JJ cord-254317-n2knqj4z 24 11 ( ( -LRB- cord-254317-n2knqj4z 24 12 Li Li NNP cord-254317-n2knqj4z 24 13 et et NNP cord-254317-n2knqj4z 24 14 al al NNP cord-254317-n2knqj4z 24 15 . . NNP cord-254317-n2knqj4z 24 16 , , , cord-254317-n2knqj4z 24 17 2017b 2017b CD cord-254317-n2knqj4z 24 18 ; ; : cord-254317-n2knqj4z 25 1 Shirato Shirato NNP cord-254317-n2knqj4z 25 2 et et FW cord-254317-n2knqj4z 25 3 al al NNP cord-254317-n2knqj4z 25 4 . . NNP cord-254317-n2knqj4z 25 5 , , , cord-254317-n2knqj4z 25 6 2016 2016 CD cord-254317-n2knqj4z 25 7 ) ) -RRB- cord-254317-n2knqj4z 25 8 . . . cord-254317-n2knqj4z 26 1 Although although IN cord-254317-n2knqj4z 26 2 the the DT cord-254317-n2knqj4z 26 3 sialic sialic JJ cord-254317-n2knqj4z 26 4 acid acid NN cord-254317-n2knqj4z 26 5 binding bind VBG cord-254317-n2knqj4z 26 6 activity activity NN cord-254317-n2knqj4z 26 7 of of IN cord-254317-n2knqj4z 26 8 S1-NTD S1-NTD NNP cord-254317-n2knqj4z 26 9 was be VBD cord-254317-n2knqj4z 26 10 observed observe VBN cord-254317-n2knqj4z 26 11 in in IN cord-254317-n2knqj4z 26 12 many many JJ cord-254317-n2knqj4z 26 13 coronaviuses coronaviuse NNS cord-254317-n2knqj4z 26 14 and and CC cord-254317-n2knqj4z 26 15 facilitated facilitate VBN cord-254317-n2knqj4z 26 16 virus virus NN cord-254317-n2knqj4z 26 17 replication replication NN cord-254317-n2knqj4z 27 1 ( ( -LRB- cord-254317-n2knqj4z 27 2 Schwegmann Schwegmann NNP cord-254317-n2knqj4z 27 3 - - HYPH cord-254317-n2knqj4z 27 4 Wessels Wessels NNP cord-254317-n2knqj4z 27 5 et et NNP cord-254317-n2knqj4z 27 6 al al NNP cord-254317-n2knqj4z 27 7 . . . cord-254317-n2knqj4z 28 1 , , , cord-254317-n2knqj4z 28 2 2011 2011 CD cord-254317-n2knqj4z 28 3 ; ; : cord-254317-n2knqj4z 28 4 Li Li NNP cord-254317-n2knqj4z 28 5 et et NNP cord-254317-n2knqj4z 28 6 al al NNP cord-254317-n2knqj4z 28 7 . . . cord-254317-n2knqj4z 29 1 , , , cord-254317-n2knqj4z 29 2 2016 2016 CD cord-254317-n2knqj4z 29 3 ; ; : cord-254317-n2knqj4z 29 4 Desmarets Desmarets NNP cord-254317-n2knqj4z 29 5 et et NNP cord-254317-n2knqj4z 29 6 al al NNP cord-254317-n2knqj4z 29 7 . . NNP cord-254317-n2knqj4z 29 8 , , , cord-254317-n2knqj4z 29 9 2014 2014 CD cord-254317-n2knqj4z 29 10 ) ) -RRB- cord-254317-n2knqj4z 29 11 , , , cord-254317-n2knqj4z 29 12 S1-NTD S1-NTD NNP cord-254317-n2knqj4z 29 13 is be VBZ cord-254317-n2knqj4z 29 14 dispensable dispensable JJ cord-254317-n2knqj4z 29 15 for for IN cord-254317-n2knqj4z 29 16 some some DT cord-254317-n2knqj4z 29 17 mutants mutant NNS cord-254317-n2knqj4z 29 18 of of IN cord-254317-n2knqj4z 29 19 transmissible transmissible JJ cord-254317-n2knqj4z 29 20 gastroenteritis gastroenteritis NN cord-254317-n2knqj4z 29 21 coronavirus coronavirus NN cord-254317-n2knqj4z 29 22 ( ( -LRB- cord-254317-n2knqj4z 29 23 TGEV TGEV NNP cord-254317-n2knqj4z 29 24 ) ) -RRB- cord-254317-n2knqj4z 29 25 and and CC cord-254317-n2knqj4z 29 26 PEDV PEDV NNP cord-254317-n2knqj4z 29 27 ( ( -LRB- cord-254317-n2knqj4z 29 28 Schwegmann Schwegmann NNP cord-254317-n2knqj4z 29 29 - - HYPH cord-254317-n2knqj4z 29 30 Wessels Wessels NNP cord-254317-n2knqj4z 29 31 et et NNP cord-254317-n2knqj4z 29 32 al al NNP cord-254317-n2knqj4z 29 33 . . NNP cord-254317-n2knqj4z 29 34 , , , cord-254317-n2knqj4z 29 35 2011 2011 CD cord-254317-n2knqj4z 29 36 ; ; : cord-254317-n2knqj4z 30 1 Oka Oka NNP cord-254317-n2knqj4z 30 2 et et NNP cord-254317-n2knqj4z 30 3 al al NNP cord-254317-n2knqj4z 30 4 . . NNP cord-254317-n2knqj4z 30 5 , , , cord-254317-n2knqj4z 30 6 2014 2014 CD cord-254317-n2knqj4z 30 7 ; ; : cord-254317-n2knqj4z 30 8 Suzuki Suzuki NNP cord-254317-n2knqj4z 30 9 et et NNP cord-254317-n2knqj4z 30 10 al al NNP cord-254317-n2knqj4z 30 11 . . NNP cord-254317-n2knqj4z 30 12 , , , cord-254317-n2knqj4z 30 13 2016 2016 CD cord-254317-n2knqj4z 30 14 ; ; . cord-254317-n2knqj4z 31 1 Hou Hou NNP cord-254317-n2knqj4z 31 2 et et NNP cord-254317-n2knqj4z 31 3 al al NNP cord-254317-n2knqj4z 31 4 . . NNP cord-254317-n2knqj4z 31 5 , , , cord-254317-n2knqj4z 31 6 2017 2017 CD cord-254317-n2knqj4z 31 7 ) ) -RRB- cord-254317-n2knqj4z 31 8 . . . cord-254317-n2knqj4z 32 1 PEDV PEDV NNP cord-254317-n2knqj4z 32 2 variants variant NNS cord-254317-n2knqj4z 32 3 with with IN cord-254317-n2knqj4z 32 4 a a DT cord-254317-n2knqj4z 32 5 big big JJ cord-254317-n2knqj4z 32 6 deletion deletion NN cord-254317-n2knqj4z 32 7 in in IN cord-254317-n2knqj4z 32 8 the the DT cord-254317-n2knqj4z 32 9 S1-NTD S1-NTD NNP cord-254317-n2knqj4z 32 10 have have VBP cord-254317-n2knqj4z 32 11 been be VBN cord-254317-n2knqj4z 32 12 designated designate VBN cord-254317-n2knqj4z 32 13 as as IN cord-254317-n2knqj4z 32 14 S1 S1 NNP cord-254317-n2knqj4z 32 15 NTD NTD NNP cord-254317-n2knqj4z 32 16 - - HYPH cord-254317-n2knqj4z 32 17 del del NNP cord-254317-n2knqj4z 32 18 PEDVs pedv NNS cord-254317-n2knqj4z 32 19 ( ( -LRB- cord-254317-n2knqj4z 32 20 Hou Hou NNP cord-254317-n2knqj4z 32 21 et et NNP cord-254317-n2knqj4z 32 22 al al NNP cord-254317-n2knqj4z 32 23 . . NNP cord-254317-n2knqj4z 32 24 , , , cord-254317-n2knqj4z 32 25 2017 2017 CD cord-254317-n2knqj4z 32 26 ) ) -RRB- cord-254317-n2knqj4z 32 27 . . . cord-254317-n2knqj4z 33 1 They -PRON- PRP cord-254317-n2knqj4z 33 2 have have VBP cord-254317-n2knqj4z 33 3 been be VBN cord-254317-n2knqj4z 33 4 detected detect VBN cord-254317-n2knqj4z 33 5 in in IN cord-254317-n2knqj4z 33 6 field field NN cord-254317-n2knqj4z 33 7 pig pig NN cord-254317-n2knqj4z 33 8 samples sample NNS cord-254317-n2knqj4z 33 9 , , , cord-254317-n2knqj4z 33 10 indicating indicate VBG cord-254317-n2knqj4z 33 11 sufficient sufficient JJ cord-254317-n2knqj4z 33 12 replication replication NN cord-254317-n2knqj4z 33 13 of of IN cord-254317-n2knqj4z 33 14 these these DT cord-254317-n2knqj4z 33 15 S1 S1 NNP cord-254317-n2knqj4z 33 16 NTD NTD NNP cord-254317-n2knqj4z 33 17 - - HYPH cord-254317-n2knqj4z 33 18 del del NNP cord-254317-n2knqj4z 33 19 PEDVs pedv NNS cord-254317-n2knqj4z 33 20 in in IN cord-254317-n2knqj4z 33 21 vivo vivo NN cord-254317-n2knqj4z 34 1 ( ( -LRB- cord-254317-n2knqj4z 34 2 Suzuki Suzuki NNP cord-254317-n2knqj4z 34 3 et et FW cord-254317-n2knqj4z 34 4 al al NNP cord-254317-n2knqj4z 34 5 . . NNP cord-254317-n2knqj4z 34 6 , , , cord-254317-n2knqj4z 34 7 2015 2015 CD cord-254317-n2knqj4z 35 1 ; ; : cord-254317-n2knqj4z 35 2 Diep Diep NNP cord-254317-n2knqj4z 35 3 et et FW cord-254317-n2knqj4z 35 4 al al NNP cord-254317-n2knqj4z 35 5 . . NNP cord-254317-n2knqj4z 35 6 , , , cord-254317-n2knqj4z 35 7 2017 2017 CD cord-254317-n2knqj4z 35 8 ; ; : cord-254317-n2knqj4z 35 9 Zhang Zhang NNP cord-254317-n2knqj4z 35 10 et et NNP cord-254317-n2knqj4z 35 11 al al NNP cord-254317-n2knqj4z 35 12 . . . cord-254317-n2knqj4z 36 1 , , , cord-254317-n2knqj4z 36 2 2018a 2018a CD cord-254317-n2knqj4z 36 3 ; ; : cord-254317-n2knqj4z 36 4 Su Su NNP cord-254317-n2knqj4z 36 5 et et FW cord-254317-n2knqj4z 36 6 al al NNP cord-254317-n2knqj4z 36 7 . . NNP cord-254317-n2knqj4z 36 8 , , , cord-254317-n2knqj4z 36 9 2018 2018 CD cord-254317-n2knqj4z 36 10 ) ) -RRB- cord-254317-n2knqj4z 36 11 . . . cord-254317-n2knqj4z 37 1 Interestingly interestingly RB cord-254317-n2knqj4z 37 2 , , , cord-254317-n2knqj4z 37 3 most most JJS cord-254317-n2knqj4z 37 4 field field NN cord-254317-n2knqj4z 37 5 S1 S1 NNP cord-254317-n2knqj4z 37 6 NTD NTD NNP cord-254317-n2knqj4z 37 7 - - HYPH cord-254317-n2knqj4z 37 8 del del NNP cord-254317-n2knqj4z 37 9 PEDVs pedv NNS cord-254317-n2knqj4z 37 10 exist exist VBP cord-254317-n2knqj4z 37 11 as as IN cord-254317-n2knqj4z 37 12 a a DT cord-254317-n2knqj4z 37 13 member member NN cord-254317-n2knqj4z 37 14 of of IN cord-254317-n2knqj4z 37 15 coinfection coinfection NN cord-254317-n2knqj4z 37 16 of of IN cord-254317-n2knqj4z 37 17 pigs pig NNS cord-254317-n2knqj4z 37 18 with with IN cord-254317-n2knqj4z 37 19 the the DT cord-254317-n2knqj4z 37 20 S s NN cord-254317-n2knqj4z 37 21 - - HYPH cord-254317-n2knqj4z 37 22 intact intact JJ cord-254317-n2knqj4z 37 23 PEDV PEDV NNP cord-254317-n2knqj4z 38 1 ( ( -LRB- cord-254317-n2knqj4z 38 2 Diep Diep NNP cord-254317-n2knqj4z 38 3 et et FW cord-254317-n2knqj4z 38 4 al al NNP cord-254317-n2knqj4z 38 5 . . NNP cord-254317-n2knqj4z 38 6 , , , cord-254317-n2knqj4z 38 7 2017 2017 CD cord-254317-n2knqj4z 38 8 ; ; : cord-254317-n2knqj4z 38 9 Su Su NNP cord-254317-n2knqj4z 38 10 et et FW cord-254317-n2knqj4z 38 11 al al NNP cord-254317-n2knqj4z 38 12 . . NNP cord-254317-n2knqj4z 38 13 , , , cord-254317-n2knqj4z 38 14 2018 2018 CD cord-254317-n2knqj4z 38 15 ) ) -RRB- cord-254317-n2knqj4z 38 16 . . . cord-254317-n2knqj4z 39 1 However however RB cord-254317-n2knqj4z 39 2 , , , cord-254317-n2knqj4z 39 3 the the DT cord-254317-n2knqj4z 39 4 mechanisms mechanism NNS cord-254317-n2knqj4z 39 5 and and CC cord-254317-n2knqj4z 39 6 consequences consequence NNS cord-254317-n2knqj4z 39 7 of of IN cord-254317-n2knqj4z 39 8 the the DT cord-254317-n2knqj4z 39 9 coinfection coinfection NN cord-254317-n2knqj4z 39 10 have have VBP cord-254317-n2knqj4z 39 11 not not RB cord-254317-n2knqj4z 39 12 been be VBN cord-254317-n2knqj4z 39 13 investigated investigate VBN cord-254317-n2knqj4z 39 14 . . . cord-254317-n2knqj4z 40 1 Studies study NNS cord-254317-n2knqj4z 40 2 showed show VBD cord-254317-n2knqj4z 40 3 that that IN cord-254317-n2knqj4z 40 4 under under IN cord-254317-n2knqj4z 40 5 unfavorable unfavorable JJ cord-254317-n2knqj4z 40 6 conditions condition NNS cord-254317-n2knqj4z 40 7 as as IN cord-254317-n2knqj4z 40 8 encountered encounter VBN cord-254317-n2knqj4z 40 9 in in IN cord-254317-n2knqj4z 40 10 the the DT cord-254317-n2knqj4z 40 11 intestinal intestinal JJ cord-254317-n2knqj4z 40 12 tract tract NN cord-254317-n2knqj4z 40 13 , , , cord-254317-n2knqj4z 40 14 sialic sialic JJ cord-254317-n2knqj4z 40 15 acid acid NN cord-254317-n2knqj4z 40 16 - - HYPH cord-254317-n2knqj4z 40 17 binding binding NN cord-254317-n2knqj4z 40 18 of of IN cord-254317-n2knqj4z 40 19 TGEV TGEV NNP cord-254317-n2knqj4z 40 20 played play VBD cord-254317-n2knqj4z 40 21 an an DT cord-254317-n2knqj4z 40 22 important important JJ cord-254317-n2knqj4z 40 23 role role NN cord-254317-n2knqj4z 40 24 in in IN cord-254317-n2knqj4z 40 25 viral viral JJ cord-254317-n2knqj4z 40 26 replication replication NN cord-254317-n2knqj4z 40 27 . . . cord-254317-n2knqj4z 41 1 When when WRB cord-254317-n2knqj4z 41 2 absorption absorption NN cord-254317-n2knqj4z 41 3 time time NN cord-254317-n2knqj4z 41 4 was be VBD cord-254317-n2knqj4z 41 5 reduced reduce VBN cord-254317-n2knqj4z 41 6 , , , cord-254317-n2knqj4z 41 7 TGEV TGEV NNP cord-254317-n2knqj4z 41 8 infectivity infectivity NN cord-254317-n2knqj4z 41 9 was be VBD cord-254317-n2knqj4z 41 10 also also RB cord-254317-n2knqj4z 41 11 reduced reduce VBN cord-254317-n2knqj4z 41 12 in in IN cord-254317-n2knqj4z 41 13 the the DT cord-254317-n2knqj4z 41 14 cells cell NNS cord-254317-n2knqj4z 41 15 whose whose WP$ cord-254317-n2knqj4z 41 16 sialic sialic JJ cord-254317-n2knqj4z 41 17 acids acid NNS cord-254317-n2knqj4z 41 18 were be VBD cord-254317-n2knqj4z 41 19 removed remove VBN cord-254317-n2knqj4z 41 20 ( ( -LRB- cord-254317-n2knqj4z 41 21 Schwegmann Schwegmann NNP cord-254317-n2knqj4z 41 22 - - HYPH cord-254317-n2knqj4z 41 23 Wessels Wessels NNP cord-254317-n2knqj4z 41 24 et et NNP cord-254317-n2knqj4z 41 25 al al NNP cord-254317-n2knqj4z 41 26 . . NNP cord-254317-n2knqj4z 41 27 , , , cord-254317-n2knqj4z 41 28 2011 2011 CD cord-254317-n2knqj4z 41 29 ) ) -RRB- cord-254317-n2knqj4z 41 30 . . . cord-254317-n2knqj4z 42 1 Consequently consequently RB cord-254317-n2knqj4z 42 2 , , , cord-254317-n2knqj4z 42 3 sialic sialic JJ cord-254317-n2knqj4z 42 4 acid acid NN cord-254317-n2knqj4z 42 5 binding bind VBG cord-254317-n2knqj4z 42 6 activity activity NN cord-254317-n2knqj4z 42 7 may may MD cord-254317-n2knqj4z 42 8 facilitate facilitate VB cord-254317-n2knqj4z 42 9 the the DT cord-254317-n2knqj4z 42 10 infection infection NN cord-254317-n2knqj4z 42 11 of of IN cord-254317-n2knqj4z 42 12 TGEV TGEV NNP cord-254317-n2knqj4z 42 13 by by IN cord-254317-n2knqj4z 42 14 helping help VBG cord-254317-n2knqj4z 42 15 the the DT cord-254317-n2knqj4z 42 16 virus virus NN cord-254317-n2knqj4z 42 17 resist resist VB cord-254317-n2knqj4z 42 18 detergent detergent NN cord-254317-n2knqj4z 42 19 - - HYPH cord-254317-n2knqj4z 42 20 like like JJ cord-254317-n2knqj4z 42 21 substances substance NNS cord-254317-n2knqj4z 42 22 encountered encounter VBN cord-254317-n2knqj4z 42 23 during during IN cord-254317-n2knqj4z 42 24 passing pass VBG cord-254317-n2knqj4z 42 25 through through IN cord-254317-n2knqj4z 42 26 the the DT cord-254317-n2knqj4z 42 27 gastrointestinal gastrointestinal JJ cord-254317-n2knqj4z 42 28 tract tract NN cord-254317-n2knqj4z 42 29 ( ( -LRB- cord-254317-n2knqj4z 42 30 Krempl Krempl NNP cord-254317-n2knqj4z 42 31 et et FW cord-254317-n2knqj4z 42 32 al al NNP cord-254317-n2knqj4z 42 33 . . NNP cord-254317-n2knqj4z 42 34 , , , cord-254317-n2knqj4z 42 35 2000 2000 CD cord-254317-n2knqj4z 42 36 ) ) -RRB- cord-254317-n2knqj4z 42 37 . . . cord-254317-n2knqj4z 43 1 Therefore therefore RB cord-254317-n2knqj4z 43 2 , , , cord-254317-n2knqj4z 43 3 we -PRON- PRP cord-254317-n2knqj4z 43 4 hypothesized hypothesize VBD cord-254317-n2knqj4z 43 5 that that IN cord-254317-n2knqj4z 43 6 mucin mucin NN cord-254317-n2knqj4z 43 7 , , , cord-254317-n2knqj4z 43 8 rich rich JJ cord-254317-n2knqj4z 43 9 in in IN cord-254317-n2knqj4z 43 10 sialic sialic JJ cord-254317-n2knqj4z 43 11 acid acid NN cord-254317-n2knqj4z 43 12 , , , cord-254317-n2knqj4z 43 13 may may MD cord-254317-n2knqj4z 43 14 enhance enhance VB cord-254317-n2knqj4z 43 15 the the DT cord-254317-n2knqj4z 43 16 infection infection NN cord-254317-n2knqj4z 43 17 of of IN cord-254317-n2knqj4z 43 18 PEDV PEDV NNP cord-254317-n2knqj4z 43 19 . . . cord-254317-n2knqj4z 44 1 Interestingly interestingly RB cord-254317-n2knqj4z 44 2 , , , cord-254317-n2knqj4z 44 3 bile bile NN cord-254317-n2knqj4z 44 4 acids acid NNS cord-254317-n2knqj4z 44 5 can can MD cord-254317-n2knqj4z 44 6 induce induce VB cord-254317-n2knqj4z 44 7 or or CC cord-254317-n2knqj4z 44 8 promote promote VB cord-254317-n2knqj4z 44 9 the the DT cord-254317-n2knqj4z 44 10 replication replication NN cord-254317-n2knqj4z 44 11 of of IN cord-254317-n2knqj4z 44 12 some some DT cord-254317-n2knqj4z 44 13 enteric enteric JJ cord-254317-n2knqj4z 44 14 viruses virus NNS cord-254317-n2knqj4z 44 15 like like IN cord-254317-n2knqj4z 44 16 a a DT cord-254317-n2knqj4z 44 17 porcine porcine JJ cord-254317-n2knqj4z 44 18 sapovirus sapovirus FW cord-254317-n2knqj4z 44 19 ( ( -LRB- cord-254317-n2knqj4z 44 20 Chang Chang NNP cord-254317-n2knqj4z 44 21 et et NNP cord-254317-n2knqj4z 44 22 al al NNP cord-254317-n2knqj4z 44 23 . . NNP cord-254317-n2knqj4z 44 24 , , , cord-254317-n2knqj4z 44 25 2004 2004 CD cord-254317-n2knqj4z 44 26 ) ) -RRB- cord-254317-n2knqj4z 44 27 and and CC cord-254317-n2knqj4z 44 28 human human JJ cord-254317-n2knqj4z 44 29 noroviruses noroviruse NNS cord-254317-n2knqj4z 45 1 ( ( -LRB- cord-254317-n2knqj4z 45 2 Ettayebi Ettayebi NNP cord-254317-n2knqj4z 45 3 et et FW cord-254317-n2knqj4z 45 4 al al NNP cord-254317-n2knqj4z 45 5 . . NNP cord-254317-n2knqj4z 45 6 , , , cord-254317-n2knqj4z 45 7 2016 2016 CD cord-254317-n2knqj4z 45 8 ) ) -RRB- cord-254317-n2knqj4z 45 9 . . . cord-254317-n2knqj4z 46 1 Since since IN cord-254317-n2knqj4z 46 2 intestinal intestinal JJ cord-254317-n2knqj4z 46 3 epithelial epithelial JJ cord-254317-n2knqj4z 46 4 cells cell NNS cord-254317-n2knqj4z 46 5 are be VBP cord-254317-n2knqj4z 46 6 exposed expose VBN cord-254317-n2knqj4z 46 7 to to IN cord-254317-n2knqj4z 46 8 bile bile NN cord-254317-n2knqj4z 46 9 acids acid NNS cord-254317-n2knqj4z 46 10 , , , cord-254317-n2knqj4z 46 11 we -PRON- PRP cord-254317-n2knqj4z 46 12 hypothesized hypothesize VBD cord-254317-n2knqj4z 46 13 that that IN cord-254317-n2knqj4z 46 14 bile bile NN cord-254317-n2knqj4z 46 15 acids acid NNS cord-254317-n2knqj4z 46 16 promote promote VBP cord-254317-n2knqj4z 46 17 PEDV PEDV NNP cord-254317-n2knqj4z 46 18 infection infection NN cord-254317-n2knqj4z 46 19 . . . cord-254317-n2knqj4z 47 1 Previously previously RB cord-254317-n2knqj4z 47 2 , , , cord-254317-n2knqj4z 47 3 we -PRON- PRP cord-254317-n2knqj4z 47 4 generated generate VBD cord-254317-n2knqj4z 47 5 two two CD cord-254317-n2knqj4z 47 6 recombinant recombinant JJ cord-254317-n2knqj4z 47 7 PEDVs pedv NNS cord-254317-n2knqj4z 47 8 , , , cord-254317-n2knqj4z 47 9 PEDV PEDV NNP cord-254317-n2knqj4z 47 10 icPC22A icPC22A NNP cord-254317-n2knqj4z 47 11 and and CC cord-254317-n2knqj4z 47 12 icPC22A icPC22A NNP cord-254317-n2knqj4z 47 13 - - HYPH cord-254317-n2knqj4z 47 14 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 48 1 ( ( -LRB- cord-254317-n2knqj4z 48 2 Hou Hou NNP cord-254317-n2knqj4z 48 3 et et NNP cord-254317-n2knqj4z 48 4 al al NNP cord-254317-n2knqj4z 48 5 . . NNP cord-254317-n2knqj4z 48 6 , , , cord-254317-n2knqj4z 48 7 2017 2017 CD cord-254317-n2knqj4z 48 8 ) ) -RRB- cord-254317-n2knqj4z 48 9 . . . cord-254317-n2knqj4z 49 1 PEDV PEDV NNP cord-254317-n2knqj4z 49 2 icPC22A icPC22A NNP cord-254317-n2knqj4z 49 3 is be VBZ cord-254317-n2knqj4z 49 4 an an DT cord-254317-n2knqj4z 49 5 infectious infectious JJ cord-254317-n2knqj4z 49 6 cDNA cdna NN cord-254317-n2knqj4z 49 7 clone clone NN cord-254317-n2knqj4z 49 8 - - HYPH cord-254317-n2knqj4z 49 9 derived derive VBN cord-254317-n2knqj4z 49 10 virus virus NN cord-254317-n2knqj4z 49 11 of of IN cord-254317-n2knqj4z 49 12 the the DT cord-254317-n2knqj4z 49 13 emerging emerge VBG cord-254317-n2knqj4z 49 14 highly highly RB cord-254317-n2knqj4z 49 15 virulent virulent JJ cord-254317-n2knqj4z 49 16 PEDV PEDV NNP cord-254317-n2knqj4z 49 17 PC22A pc22a NN cord-254317-n2knqj4z 49 18 strain strain NN cord-254317-n2knqj4z 49 19 . . . cord-254317-n2knqj4z 50 1 On on IN cord-254317-n2knqj4z 50 2 the the DT cord-254317-n2knqj4z 50 3 other other JJ cord-254317-n2knqj4z 50 4 hand hand NN cord-254317-n2knqj4z 50 5 , , , cord-254317-n2knqj4z 50 6 PEDV PEDV NNP cord-254317-n2knqj4z 50 7 icPC22A icPC22A NNP cord-254317-n2knqj4z 50 8 - - HYPH cord-254317-n2knqj4z 50 9 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 50 10 is be VBZ cord-254317-n2knqj4z 50 11 a a DT cord-254317-n2knqj4z 50 12 mutant mutant JJ cord-254317-n2knqj4z 50 13 version version NN cord-254317-n2knqj4z 50 14 of of IN cord-254317-n2knqj4z 50 15 icPC22A icPC22A NNP cord-254317-n2knqj4z 50 16 bearing bear VBG cord-254317-n2knqj4z 50 17 a a DT cord-254317-n2knqj4z 50 18 197-aa 197-aa CD cord-254317-n2knqj4z 50 19 deletion deletion NN cord-254317-n2knqj4z 50 20 ( ( -LRB- cord-254317-n2knqj4z 50 21 residues residue NNS cord-254317-n2knqj4z 50 22 34 34 CD cord-254317-n2knqj4z 50 23 - - SYM cord-254317-n2knqj4z 50 24 230 230 CD cord-254317-n2knqj4z 50 25 ) ) -RRB- cord-254317-n2knqj4z 50 26 in in IN cord-254317-n2knqj4z 50 27 the the DT cord-254317-n2knqj4z 50 28 S1 S1 NNP cord-254317-n2knqj4z 50 29 NTD NTD NNP cord-254317-n2knqj4z 50 30 region region NN cord-254317-n2knqj4z 50 31 , , , cord-254317-n2knqj4z 50 32 corresponding correspond VBG cord-254317-n2knqj4z 50 33 to to IN cord-254317-n2knqj4z 50 34 the the DT cord-254317-n2knqj4z 50 35 S1 S1 NNP cord-254317-n2knqj4z 50 36 domain domain NN cord-254317-n2knqj4z 50 37 0 0 CD cord-254317-n2knqj4z 50 38 ( ( -LRB- cord-254317-n2knqj4z 50 39 S1 s1 NN cord-254317-n2knqj4z 50 40 ° ° NN cord-254317-n2knqj4z 50 41 ) ) -RRB- cord-254317-n2knqj4z 50 42 of of IN cord-254317-n2knqj4z 50 43 the the DT cord-254317-n2knqj4z 50 44 spike spike NN cord-254317-n2knqj4z 50 45 protein protein NN cord-254317-n2knqj4z 50 46 ( ( -LRB- cord-254317-n2knqj4z 50 47 Li Li NNP cord-254317-n2knqj4z 50 48 et et NNP cord-254317-n2knqj4z 50 49 al al NNP cord-254317-n2knqj4z 50 50 . . NNP cord-254317-n2knqj4z 50 51 , , , cord-254317-n2knqj4z 50 52 2017a 2017a CD cord-254317-n2knqj4z 50 53 ; ; : cord-254317-n2knqj4z 50 54 Hou Hou NNP cord-254317-n2knqj4z 50 55 et et NNP cord-254317-n2knqj4z 50 56 al al NNP cord-254317-n2knqj4z 50 57 . . NNP cord-254317-n2knqj4z 50 58 , , , cord-254317-n2knqj4z 50 59 2017 2017 CD cord-254317-n2knqj4z 50 60 ) ) -RRB- cord-254317-n2knqj4z 50 61 . . . cord-254317-n2knqj4z 51 1 In in IN cord-254317-n2knqj4z 51 2 this this DT cord-254317-n2knqj4z 51 3 study study NN cord-254317-n2knqj4z 51 4 , , , cord-254317-n2knqj4z 51 5 we -PRON- PRP cord-254317-n2knqj4z 51 6 investigated investigate VBD cord-254317-n2knqj4z 51 7 the the DT cord-254317-n2knqj4z 51 8 replication replication NN cord-254317-n2knqj4z 51 9 and and CC cord-254317-n2knqj4z 51 10 pathogenesis pathogenesis NN cord-254317-n2knqj4z 51 11 of of IN cord-254317-n2knqj4z 51 12 the the DT cord-254317-n2knqj4z 51 13 two two CD cord-254317-n2knqj4z 51 14 viruses virus NNS cord-254317-n2knqj4z 51 15 during during IN cord-254317-n2knqj4z 51 16 coinfection coinfection NN cord-254317-n2knqj4z 51 17 in in IN cord-254317-n2knqj4z 51 18 neonatal neonatal JJ cord-254317-n2knqj4z 51 19 gnotobiotic gnotobiotic JJ cord-254317-n2knqj4z 51 20 ( ( -LRB- cord-254317-n2knqj4z 51 21 Gn Gn NNP cord-254317-n2knqj4z 51 22 ) ) -RRB- cord-254317-n2knqj4z 51 23 piglets piglet NNS cord-254317-n2knqj4z 51 24 . . . cord-254317-n2knqj4z 52 1 Some some DT cord-254317-n2knqj4z 52 2 intestinal intestinal JJ cord-254317-n2knqj4z 52 3 substances substance NNS cord-254317-n2knqj4z 52 4 ( ( -LRB- cord-254317-n2knqj4z 52 5 mucin mucin NN cord-254317-n2knqj4z 52 6 , , , cord-254317-n2knqj4z 52 7 bile bile NN cord-254317-n2knqj4z 52 8 and and CC cord-254317-n2knqj4z 52 9 bile bile NN cord-254317-n2knqj4z 52 10 acids acid NNS cord-254317-n2knqj4z 52 11 ) ) -RRB- cord-254317-n2knqj4z 52 12 were be VBD cord-254317-n2knqj4z 52 13 tested test VBN cord-254317-n2knqj4z 52 14 for for IN cord-254317-n2knqj4z 52 15 their -PRON- PRP$ cord-254317-n2knqj4z 52 16 effects effect NNS cord-254317-n2knqj4z 52 17 on on IN cord-254317-n2knqj4z 52 18 the the DT cord-254317-n2knqj4z 52 19 infection infection NN cord-254317-n2knqj4z 52 20 of of IN cord-254317-n2knqj4z 52 21 the the DT cord-254317-n2knqj4z 52 22 individual individual JJ cord-254317-n2knqj4z 52 23 viruses virus NNS cord-254317-n2knqj4z 52 24 in in IN cord-254317-n2knqj4z 52 25 vitro vitro FW cord-254317-n2knqj4z 52 26 . . . cord-254317-n2knqj4z 53 1 We -PRON- PRP cord-254317-n2knqj4z 53 2 selected select VBD cord-254317-n2knqj4z 53 3 two two CD cord-254317-n2knqj4z 53 4 cell cell NN cord-254317-n2knqj4z 53 5 lines line NNS cord-254317-n2knqj4z 53 6 , , , cord-254317-n2knqj4z 53 7 Vero Vero NNP cord-254317-n2knqj4z 53 8 and and CC cord-254317-n2knqj4z 53 9 IPEC IPEC NNP cord-254317-n2knqj4z 53 10 - - HYPH cord-254317-n2knqj4z 53 11 DQ dq NN cord-254317-n2knqj4z 53 12 cells cell NNS cord-254317-n2knqj4z 53 13 . . . cord-254317-n2knqj4z 54 1 Vero Vero NNP cord-254317-n2knqj4z 54 2 cells cell NNS cord-254317-n2knqj4z 54 3 are be VBP cord-254317-n2knqj4z 54 4 the the DT cord-254317-n2knqj4z 54 5 most most RBS cord-254317-n2knqj4z 54 6 commonly commonly RB cord-254317-n2knqj4z 54 7 used use VBN cord-254317-n2knqj4z 54 8 cell cell NN cord-254317-n2knqj4z 54 9 line line NN cord-254317-n2knqj4z 54 10 for for IN cord-254317-n2knqj4z 54 11 PEDV PEDV NNP cord-254317-n2knqj4z 54 12 isolation isolation NN cord-254317-n2knqj4z 54 13 and and CC cord-254317-n2knqj4z 54 14 propagation propagation NN cord-254317-n2knqj4z 54 15 ( ( -LRB- cord-254317-n2knqj4z 54 16 Teeravechyan Teeravechyan NNP cord-254317-n2knqj4z 54 17 et et NNP cord-254317-n2knqj4z 54 18 al al NNP cord-254317-n2knqj4z 54 19 . . NNP cord-254317-n2knqj4z 54 20 , , , cord-254317-n2knqj4z 54 21 2016 2016 CD cord-254317-n2knqj4z 54 22 ) ) -RRB- cord-254317-n2knqj4z 54 23 . . . cord-254317-n2knqj4z 55 1 IPEC IPEC NNP cord-254317-n2knqj4z 55 2 - - HYPH cord-254317-n2knqj4z 55 3 DQ dq NN cord-254317-n2knqj4z 55 4 cell cell NN cord-254317-n2knqj4z 55 5 is be VBZ cord-254317-n2knqj4z 55 6 a a DT cord-254317-n2knqj4z 55 7 subclone subclone NN cord-254317-n2knqj4z 55 8 of of IN cord-254317-n2knqj4z 55 9 porcine porcine JJ cord-254317-n2knqj4z 55 10 small small JJ cord-254317-n2knqj4z 55 11 intestinal intestinal JJ cord-254317-n2knqj4z 55 12 cell cell NN cord-254317-n2knqj4z 55 13 line line NN cord-254317-n2knqj4z 55 14 IPEC IPEC NNP cord-254317-n2knqj4z 55 15 - - HYPH cord-254317-n2knqj4z 55 16 J2 J2 NNP cord-254317-n2knqj4z 56 1 ( ( -LRB- cord-254317-n2knqj4z 56 2 Zhang Zhang NNP cord-254317-n2knqj4z 56 3 et et NNP cord-254317-n2knqj4z 56 4 al al NNP cord-254317-n2knqj4z 56 5 . . NNP cord-254317-n2knqj4z 56 6 , , , cord-254317-n2knqj4z 56 7 2018b 2018b CD cord-254317-n2knqj4z 56 8 ) ) -RRB- cord-254317-n2knqj4z 56 9 . . . cord-254317-n2knqj4z 57 1 Although although IN cord-254317-n2knqj4z 57 2 PEDV PEDV NNP cord-254317-n2knqj4z 57 3 grows grow VBZ cord-254317-n2knqj4z 57 4 less less RBR cord-254317-n2knqj4z 57 5 efficiently efficiently RB cord-254317-n2knqj4z 57 6 in in IN cord-254317-n2knqj4z 57 7 IPEC IPEC NNP cord-254317-n2knqj4z 57 8 - - HYPH cord-254317-n2knqj4z 57 9 DQ dq NN cord-254317-n2knqj4z 57 10 cells cell NNS cord-254317-n2knqj4z 57 11 than than IN cord-254317-n2knqj4z 57 12 in in IN cord-254317-n2knqj4z 57 13 Vero Vero NNP cord-254317-n2knqj4z 57 14 cells cell NNS cord-254317-n2knqj4z 57 15 , , , cord-254317-n2knqj4z 57 16 PEDV PEDV NNP cord-254317-n2knqj4z 57 17 infection infection NN cord-254317-n2knqj4z 57 18 of of IN cord-254317-n2knqj4z 57 19 IPEC IPEC NNP cord-254317-n2knqj4z 57 20 - - HYPH cord-254317-n2knqj4z 57 21 DQ dq NN cord-254317-n2knqj4z 57 22 cells cell NNS cord-254317-n2knqj4z 57 23 is be VBZ cord-254317-n2knqj4z 57 24 more more RBR cord-254317-n2knqj4z 57 25 relevant relevant JJ cord-254317-n2knqj4z 57 26 physiologically physiologically RB cord-254317-n2knqj4z 57 27 to to IN cord-254317-n2knqj4z 57 28 PEDV PEDV NNP cord-254317-n2knqj4z 57 29 natural natural JJ cord-254317-n2knqj4z 57 30 infection infection NN cord-254317-n2knqj4z 57 31 in in IN cord-254317-n2knqj4z 57 32 the the DT cord-254317-n2knqj4z 57 33 intestines intestine NNS cord-254317-n2knqj4z 57 34 of of IN cord-254317-n2knqj4z 57 35 pigs pig NNS cord-254317-n2knqj4z 57 36 . . . cord-254317-n2knqj4z 58 1 Vero Vero NNP cord-254317-n2knqj4z 58 2 cells cell NNS cord-254317-n2knqj4z 58 3 ( ( -LRB- cord-254317-n2knqj4z 59 1 ATCC atcc JJ cord-254317-n2knqj4z 59 2 number number NN cord-254317-n2knqj4z 59 3 CCL81 CCL81 NNP cord-254317-n2knqj4z 59 4 ) ) -RRB- cord-254317-n2knqj4z 59 5 were be VBD cord-254317-n2knqj4z 59 6 cultured culture VBN cord-254317-n2knqj4z 59 7 in in IN cord-254317-n2knqj4z 59 8 Dulbecco Dulbecco NNP cord-254317-n2knqj4z 59 9 's 's POS cord-254317-n2knqj4z 59 10 modified modify VBN cord-254317-n2knqj4z 59 11 Eagle Eagle NNP cord-254317-n2knqj4z 59 12 's 's POS cord-254317-n2knqj4z 59 13 medium medium NN cord-254317-n2knqj4z 59 14 ( ( -LRB- cord-254317-n2knqj4z 59 15 DMEM DMEM NNP cord-254317-n2knqj4z 59 16 , , , cord-254317-n2knqj4z 59 17 Gibco Gibco NNP cord-254317-n2knqj4z 59 18 , , , cord-254317-n2knqj4z 59 19 Carlsbad Carlsbad NNP cord-254317-n2knqj4z 59 20 , , , cord-254317-n2knqj4z 59 21 CA CA NNP cord-254317-n2knqj4z 59 22 , , , cord-254317-n2knqj4z 59 23 USA USA NNP cord-254317-n2knqj4z 59 24 ) ) -RRB- cord-254317-n2knqj4z 59 25 supplemented supplement VBD cord-254317-n2knqj4z 59 26 with with IN cord-254317-n2knqj4z 59 27 5 5 CD cord-254317-n2knqj4z 59 28 % % NN cord-254317-n2knqj4z 59 29 fetal fetal JJ cord-254317-n2knqj4z 59 30 bovine bovine JJ cord-254317-n2knqj4z 59 31 serum serum NN cord-254317-n2knqj4z 59 32 ( ( -LRB- cord-254317-n2knqj4z 59 33 FBS FBS NNP cord-254317-n2knqj4z 59 34 , , , cord-254317-n2knqj4z 59 35 HyClone HyClone NNP cord-254317-n2knqj4z 59 36 , , , cord-254317-n2knqj4z 59 37 Logan Logan NNP cord-254317-n2knqj4z 59 38 , , , cord-254317-n2knqj4z 59 39 UT UT NNP cord-254317-n2knqj4z 59 40 , , , cord-254317-n2knqj4z 59 41 USA USA NNP cord-254317-n2knqj4z 59 42 ) ) -RRB- cord-254317-n2knqj4z 59 43 and and CC cord-254317-n2knqj4z 59 44 1 1 CD cord-254317-n2knqj4z 59 45 % % NN cord-254317-n2knqj4z 59 46 penicillin penicillin NN cord-254317-n2knqj4z 59 47 / / SYM cord-254317-n2knqj4z 59 48 streptomycin streptomycin NN cord-254317-n2knqj4z 59 49 ( ( -LRB- cord-254317-n2knqj4z 59 50 Gibco Gibco NNP cord-254317-n2knqj4z 59 51 ) ) -RRB- cord-254317-n2knqj4z 59 52 . . . cord-254317-n2knqj4z 60 1 For for IN cord-254317-n2knqj4z 60 2 virus virus NN cord-254317-n2knqj4z 60 3 propagation propagation NN cord-254317-n2knqj4z 60 4 in in IN cord-254317-n2knqj4z 60 5 Vero Vero NNP cord-254317-n2knqj4z 60 6 cells cell NNS cord-254317-n2knqj4z 60 7 , , , cord-254317-n2knqj4z 60 8 the the DT cord-254317-n2knqj4z 60 9 maintenance maintenance NN cord-254317-n2knqj4z 60 10 medium medium NN cord-254317-n2knqj4z 60 11 was be VBD cord-254317-n2knqj4z 60 12 DMEM DMEM NNP cord-254317-n2knqj4z 60 13 supplemented supplement VBN cord-254317-n2knqj4z 60 14 with with IN cord-254317-n2knqj4z 60 15 0.3 0.3 CD cord-254317-n2knqj4z 60 16 % % NN cord-254317-n2knqj4z 60 17 tryptose tryptose JJ cord-254317-n2knqj4z 60 18 phosphate phosphate NN cord-254317-n2knqj4z 60 19 broth broth NN cord-254317-n2knqj4z 60 20 solution solution NN cord-254317-n2knqj4z 60 21 ( ( -LRB- cord-254317-n2knqj4z 60 22 TPB TPB NNP cord-254317-n2knqj4z 60 23 , , , cord-254317-n2knqj4z 60 24 Sigma Sigma NNP cord-254317-n2knqj4z 60 25 , , , cord-254317-n2knqj4z 60 26 St. St. NNP cord-254317-n2knqj4z 60 27 Louis Louis NNP cord-254317-n2knqj4z 60 28 , , , cord-254317-n2knqj4z 60 29 MO MO NNP cord-254317-n2knqj4z 60 30 , , , cord-254317-n2knqj4z 60 31 USA USA NNP cord-254317-n2knqj4z 60 32 ) ) -RRB- cord-254317-n2knqj4z 60 33 , , , cord-254317-n2knqj4z 60 34 1 1 CD cord-254317-n2knqj4z 60 35 % % NN cord-254317-n2knqj4z 60 36 Penicillin Penicillin NNP cord-254317-n2knqj4z 60 37 / / SYM cord-254317-n2knqj4z 60 38 Streptomycin Streptomycin NNP cord-254317-n2knqj4z 60 39 ( ( -LRB- cord-254317-n2knqj4z 60 40 Gibco Gibco NNP cord-254317-n2knqj4z 60 41 ) ) -RRB- cord-254317-n2knqj4z 60 42 and and CC cord-254317-n2knqj4z 60 43 10 10 CD cord-254317-n2knqj4z 60 44 μg μg NN cord-254317-n2knqj4z 60 45 / / SYM cord-254317-n2knqj4z 60 46 mL ml NN cord-254317-n2knqj4z 60 47 trypsin trypsin NN cord-254317-n2knqj4z 60 48 ( ( -LRB- cord-254317-n2knqj4z 60 49 2.5 2.5 CD cord-254317-n2knqj4z 60 50 % % NN cord-254317-n2knqj4z 60 51 Trypsin Trypsin NNP cord-254317-n2knqj4z 60 52 , , , cord-254317-n2knqj4z 60 53 Gibco Gibco NNP cord-254317-n2knqj4z 60 54 ) ) -RRB- cord-254317-n2knqj4z 60 55 . . . cord-254317-n2knqj4z 61 1 IPEC IPEC NNP cord-254317-n2knqj4z 61 2 - - HYPH cord-254317-n2knqj4z 61 3 DQ dq NN cord-254317-n2knqj4z 61 4 cell cell NN cord-254317-n2knqj4z 61 5 line line NN cord-254317-n2knqj4z 61 6 was be VBD cord-254317-n2knqj4z 61 7 a a DT cord-254317-n2knqj4z 61 8 gift gift NN cord-254317-n2knqj4z 61 9 from from IN cord-254317-n2knqj4z 61 10 Dr. Dr. NNP cord-254317-n2knqj4z 61 11 Dongwan Dongwan NNP cord-254317-n2knqj4z 61 12 Yoo Yoo NNP cord-254317-n2knqj4z 61 13 , , , cord-254317-n2knqj4z 61 14 University University NNP cord-254317-n2knqj4z 61 15 of of IN cord-254317-n2knqj4z 61 16 Illinois Illinois NNP cord-254317-n2knqj4z 61 17 at at IN cord-254317-n2knqj4z 61 18 Urbana Urbana NNP cord-254317-n2knqj4z 61 19 - - HYPH cord-254317-n2knqj4z 61 20 Champaign Champaign NNP cord-254317-n2knqj4z 61 21 , , , cord-254317-n2knqj4z 61 22 Urbana Urbana NNP cord-254317-n2knqj4z 61 23 IL IL NNP cord-254317-n2knqj4z 61 24 , , , cord-254317-n2knqj4z 61 25 USA USA NNP cord-254317-n2knqj4z 61 26 . . . cord-254317-n2knqj4z 62 1 It -PRON- PRP cord-254317-n2knqj4z 62 2 was be VBD cord-254317-n2knqj4z 62 3 a a DT cord-254317-n2knqj4z 62 4 subclone subclone NN cord-254317-n2knqj4z 62 5 of of IN cord-254317-n2knqj4z 62 6 IPEC IPEC NNP cord-254317-n2knqj4z 62 7 - - HYPH cord-254317-n2knqj4z 62 8 J2 J2 NNP cord-254317-n2knqj4z 62 9 cells cell NNS cord-254317-n2knqj4z 62 10 , , , cord-254317-n2knqj4z 62 11 a a DT cord-254317-n2knqj4z 62 12 porcine porcine JJ cord-254317-n2knqj4z 62 13 small small JJ cord-254317-n2knqj4z 62 14 intestinal intestinal JJ cord-254317-n2knqj4z 62 15 cell cell NN cord-254317-n2knqj4z 62 16 line line NN cord-254317-n2knqj4z 62 17 , , , cord-254317-n2knqj4z 62 18 and and CC cord-254317-n2knqj4z 62 19 maintained maintain VBD cord-254317-n2knqj4z 62 20 in in IN cord-254317-n2knqj4z 62 21 Roswell Roswell NNP cord-254317-n2knqj4z 62 22 Park Park NNP cord-254317-n2knqj4z 62 23 Memorial Memorial NNP cord-254317-n2knqj4z 62 24 Institute Institute NNP cord-254317-n2knqj4z 62 25 1640 1640 CD cord-254317-n2knqj4z 62 26 Medium Medium NNP cord-254317-n2knqj4z 62 27 ( ( -LRB- cord-254317-n2knqj4z 62 28 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 62 29 , , , cord-254317-n2knqj4z 62 30 Gibco Gibco NNP cord-254317-n2knqj4z 62 31 ) ) -RRB- cord-254317-n2knqj4z 62 32 supplemented supplement VBD cord-254317-n2knqj4z 62 33 with with IN cord-254317-n2knqj4z 62 34 10 10 CD cord-254317-n2knqj4z 62 35 % % NN cord-254317-n2knqj4z 62 36 FBS FBS NNP cord-254317-n2knqj4z 62 37 and and CC cord-254317-n2knqj4z 62 38 1 1 CD cord-254317-n2knqj4z 62 39 % % NN cord-254317-n2knqj4z 62 40 penicillin penicillin NN cord-254317-n2knqj4z 62 41 / / SYM cord-254317-n2knqj4z 62 42 streptomycin streptomycin NN cord-254317-n2knqj4z 62 43 ( ( -LRB- cord-254317-n2knqj4z 62 44 Zhang Zhang NNP cord-254317-n2knqj4z 62 45 et et NNP cord-254317-n2knqj4z 62 46 al al NNP cord-254317-n2knqj4z 62 47 . . NNP cord-254317-n2knqj4z 62 48 , , , cord-254317-n2knqj4z 62 49 2018b 2018b CD cord-254317-n2knqj4z 62 50 ) ) -RRB- cord-254317-n2knqj4z 62 51 . . . cord-254317-n2knqj4z 63 1 For for IN cord-254317-n2knqj4z 63 2 virus virus NN cord-254317-n2knqj4z 63 3 propagation propagation NN cord-254317-n2knqj4z 63 4 in in IN cord-254317-n2knqj4z 63 5 IPEC IPEC NNP cord-254317-n2knqj4z 63 6 - - HYPH cord-254317-n2knqj4z 63 7 DQ dq NN cord-254317-n2knqj4z 63 8 cells cell NNS cord-254317-n2knqj4z 63 9 , , , cord-254317-n2knqj4z 63 10 maintenance maintenance NN cord-254317-n2knqj4z 63 11 medium medium NN cord-254317-n2knqj4z 63 12 was be VBD cord-254317-n2knqj4z 63 13 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 63 14 containing contain VBG cord-254317-n2knqj4z 63 15 0.3 0.3 CD cord-254317-n2knqj4z 63 16 % % NN cord-254317-n2knqj4z 63 17 TPB TPB NNP cord-254317-n2knqj4z 63 18 , , , cord-254317-n2knqj4z 63 19 1 1 CD cord-254317-n2knqj4z 63 20 % % NN cord-254317-n2knqj4z 63 21 Penicillin Penicillin NNP cord-254317-n2knqj4z 63 22 / / SYM cord-254317-n2knqj4z 63 23 Streptomycin Streptomycin NNP cord-254317-n2knqj4z 63 24 and and CC cord-254317-n2knqj4z 63 25 1 1 CD cord-254317-n2knqj4z 63 26 μg μg NN cord-254317-n2knqj4z 63 27 / / SYM cord-254317-n2knqj4z 63 28 mL ml NN cord-254317-n2knqj4z 63 29 trypsin trypsin NN cord-254317-n2knqj4z 63 30 . . . cord-254317-n2knqj4z 64 1 Two two CD cord-254317-n2knqj4z 64 2 recombinant recombinant JJ cord-254317-n2knqj4z 64 3 PEDV PEDV NNP cord-254317-n2knqj4z 64 4 , , , cord-254317-n2knqj4z 64 5 icPC22A icPC22A NNP cord-254317-n2knqj4z 64 6 and and CC cord-254317-n2knqj4z 64 7 icPC22A icPC22A NNP cord-254317-n2knqj4z 64 8 - - HYPH cord-254317-n2knqj4z 64 9 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 64 10 , , , cord-254317-n2knqj4z 64 11 were be VBD cord-254317-n2knqj4z 64 12 generated generate VBN cord-254317-n2knqj4z 64 13 previously previously RB cord-254317-n2knqj4z 64 14 by by IN cord-254317-n2knqj4z 64 15 our -PRON- PRP$ cord-254317-n2knqj4z 64 16 lab lab NN cord-254317-n2knqj4z 64 17 using use VBG cord-254317-n2knqj4z 64 18 the the DT cord-254317-n2knqj4z 64 19 infectious infectious JJ cord-254317-n2knqj4z 64 20 clone clone NN cord-254317-n2knqj4z 64 21 of of IN cord-254317-n2knqj4z 64 22 PEDV PEDV NNP cord-254317-n2knqj4z 64 23 PC22A pc22a NN cord-254317-n2knqj4z 64 24 strain strain NN cord-254317-n2knqj4z 64 25 ( ( -LRB- cord-254317-n2knqj4z 64 26 Hou Hou NNP cord-254317-n2knqj4z 64 27 et et FW cord-254317-n2knqj4z 64 28 al al NNP cord-254317-n2knqj4z 64 29 . . NNP cord-254317-n2knqj4z 64 30 , , , cord-254317-n2knqj4z 64 31 2017 2017 CD cord-254317-n2knqj4z 64 32 ) ) -RRB- cord-254317-n2knqj4z 64 33 . . . cord-254317-n2knqj4z 65 1 Neuraminidase Neuraminidase NNP cord-254317-n2knqj4z 65 2 ( ( -LRB- cord-254317-n2knqj4z 65 3 NA NA NNP cord-254317-n2knqj4z 65 4 , , , cord-254317-n2knqj4z 65 5 from from IN cord-254317-n2knqj4z 65 6 Clostridium Clostridium NNP cord-254317-n2knqj4z 65 7 welchii welchii NNP cord-254317-n2knqj4z 65 8 ) ) -RRB- cord-254317-n2knqj4z 65 9 , , , cord-254317-n2knqj4z 65 10 porcine porcine JJ cord-254317-n2knqj4z 65 11 gastric gastric JJ cord-254317-n2knqj4z 65 12 mucin mucin NN cord-254317-n2knqj4z 65 13 ( ( -LRB- cord-254317-n2knqj4z 65 14 PGM PGM NNP cord-254317-n2knqj4z 65 15 ) ) -RRB- cord-254317-n2knqj4z 65 16 and and CC cord-254317-n2knqj4z 65 17 several several JJ cord-254317-n2knqj4z 65 18 bile bile NN cord-254317-n2knqj4z 65 19 acids acid NNS cord-254317-n2knqj4z 65 20 [ [ -LRB- cord-254317-n2knqj4z 65 21 ( ( -LRB- cord-254317-n2knqj4z 65 22 glycochenodeoxycholic glycochenodeoxycholic JJ cord-254317-n2knqj4z 65 23 acid acid NN cord-254317-n2knqj4z 65 24 ( ( -LRB- cord-254317-n2knqj4z 65 25 GCDCA GCDCA NNP cord-254317-n2knqj4z 65 26 ) ) -RRB- cord-254317-n2knqj4z 65 27 , , , cord-254317-n2knqj4z 65 28 chenodeoxycholic chenodeoxycholic JJ cord-254317-n2knqj4z 65 29 acid acid NNP cord-254317-n2knqj4z 65 30 ( ( -LRB- cord-254317-n2knqj4z 65 31 CDCA CDCA NNP cord-254317-n2knqj4z 65 32 ) ) -RRB- cord-254317-n2knqj4z 65 33 , , , cord-254317-n2knqj4z 65 34 deoxycholic deoxycholic JJ cord-254317-n2knqj4z 65 35 acid acid NNP cord-254317-n2knqj4z 65 36 ( ( -LRB- cord-254317-n2knqj4z 65 37 DCA DCA NNP cord-254317-n2knqj4z 65 38 ) ) -RRB- cord-254317-n2knqj4z 65 39 , , , cord-254317-n2knqj4z 65 40 and and CC cord-254317-n2knqj4z 65 41 ursodeoxycholic ursodeoxycholic JJ cord-254317-n2knqj4z 65 42 acid acid NN cord-254317-n2knqj4z 65 43 ( ( -LRB- cord-254317-n2knqj4z 65 44 UDCA UDCA NNP cord-254317-n2knqj4z 65 45 ) ) -RRB- cord-254317-n2knqj4z 65 46 ] ] -RRB- cord-254317-n2knqj4z 65 47 were be VBD cord-254317-n2knqj4z 65 48 all all DT cord-254317-n2knqj4z 65 49 purchased purchase VBN cord-254317-n2knqj4z 65 50 from from IN cord-254317-n2knqj4z 65 51 Sigma Sigma NNP cord-254317-n2knqj4z 65 52 . . . cord-254317-n2knqj4z 66 1 Bovine bovine JJ cord-254317-n2knqj4z 66 2 mucin mucin NN cord-254317-n2knqj4z 66 3 ( ( -LRB- cord-254317-n2knqj4z 66 4 BM BM NNP cord-254317-n2knqj4z 66 5 ) ) -RRB- cord-254317-n2knqj4z 66 6 was be VBD cord-254317-n2knqj4z 66 7 purchased purchase VBN cord-254317-n2knqj4z 66 8 from from IN cord-254317-n2knqj4z 66 9 Worthington Worthington NNP cord-254317-n2knqj4z 66 10 ( ( -LRB- cord-254317-n2knqj4z 66 11 Worthington Worthington NNP cord-254317-n2knqj4z 66 12 Biochemical Biochemical NNP cord-254317-n2knqj4z 66 13 Corp. Corp. NNP cord-254317-n2knqj4z 66 14 , , , cord-254317-n2knqj4z 66 15 Lakewood Lakewood NNP cord-254317-n2knqj4z 66 16 , , , cord-254317-n2knqj4z 66 17 NJ NJ NNP cord-254317-n2knqj4z 66 18 , , , cord-254317-n2knqj4z 66 19 USA USA NNP cord-254317-n2knqj4z 66 20 ) ) -RRB- cord-254317-n2knqj4z 66 21 . . . cord-254317-n2knqj4z 67 1 Swine swine NN cord-254317-n2knqj4z 67 2 bile bile NN cord-254317-n2knqj4z 67 3 was be VBD cord-254317-n2knqj4z 67 4 collected collect VBN cord-254317-n2knqj4z 67 5 from from IN cord-254317-n2knqj4z 67 6 a a DT cord-254317-n2knqj4z 67 7 pregnant pregnant JJ cord-254317-n2knqj4z 67 8 sow sow NN cord-254317-n2knqj4z 67 9 after after IN cord-254317-n2knqj4z 67 10 C c NN cord-254317-n2knqj4z 67 11 - - HYPH cord-254317-n2knqj4z 67 12 section section NN cord-254317-n2knqj4z 67 13 surgery surgery NN cord-254317-n2knqj4z 67 14 . . . cord-254317-n2knqj4z 68 1 The the DT cord-254317-n2knqj4z 68 2 mouse mouse NN cord-254317-n2knqj4z 68 3 monoclonal monoclonal JJ cord-254317-n2knqj4z 68 4 antibodies antibody NNS cord-254317-n2knqj4z 68 5 ( ( -LRB- cord-254317-n2knqj4z 68 6 MAb MAb NNS cord-254317-n2knqj4z 68 7 ) ) -RRB- cord-254317-n2knqj4z 68 8 56H4 56h4 CD cord-254317-n2knqj4z 68 9 , , , cord-254317-n2knqj4z 68 10 60F11 60f11 CD cord-254317-n2knqj4z 68 11 and and CC cord-254317-n2knqj4z 68 12 72 72 CD cord-254317-n2knqj4z 68 13 A8 a8 NN cord-254317-n2knqj4z 68 14 targeting target VBG cord-254317-n2knqj4z 68 15 the the DT cord-254317-n2knqj4z 68 16 S1 s1 NN cord-254317-n2knqj4z 68 17 ° ° NN cord-254317-n2knqj4z 68 18 domain domain NN cord-254317-n2knqj4z 68 19 of of IN cord-254317-n2knqj4z 68 20 PEDV PEDV NNP cord-254317-n2knqj4z 68 21 S S NNP cord-254317-n2knqj4z 68 22 protein protein NN cord-254317-n2knqj4z 68 23 ( ( -LRB- cord-254317-n2knqj4z 68 24 Fig fig NN cord-254317-n2knqj4z 68 25 . . . cord-254317-n2knqj4z 69 1 S1A S1A NNP cord-254317-n2knqj4z 69 2 ) ) -RRB- cord-254317-n2knqj4z 69 3 was be VBD cord-254317-n2knqj4z 69 4 provided provide VBN cord-254317-n2knqj4z 69 5 by by IN cord-254317-n2knqj4z 69 6 Dr. Dr. NNP cord-254317-n2knqj4z 69 7 Berend Berend NNP cord-254317-n2knqj4z 69 8 Jan Jan NNP cord-254317-n2knqj4z 69 9 Bosch Bosch NNP cord-254317-n2knqj4z 69 10 , , , cord-254317-n2knqj4z 69 11 Utrecht Utrecht NNP cord-254317-n2knqj4z 69 12 University University NNP cord-254317-n2knqj4z 69 13 , , , cord-254317-n2knqj4z 69 14 Utrecht Utrecht NNP cord-254317-n2knqj4z 69 15 , , , cord-254317-n2knqj4z 69 16 Netherlands Netherlands NNP cord-254317-n2knqj4z 69 17 ( ( -LRB- cord-254317-n2knqj4z 69 18 Li Li NNP cord-254317-n2knqj4z 69 19 et et NNP cord-254317-n2knqj4z 69 20 al al NNP cord-254317-n2knqj4z 69 21 . . NNP cord-254317-n2knqj4z 69 22 , , , cord-254317-n2knqj4z 69 23 2017a 2017a CD cord-254317-n2knqj4z 69 24 ) ) -RRB- cord-254317-n2knqj4z 69 25 . . . cord-254317-n2knqj4z 70 1 The the DT cord-254317-n2knqj4z 70 2 MAb MAb NNS cord-254317-n2knqj4z 70 3 SD6 sd6 JJ cord-254317-n2knqj4z 70 4 - - HYPH cord-254317-n2knqj4z 70 5 29 29 CD cord-254317-n2knqj4z 70 6 targeting target VBG cord-254317-n2knqj4z 70 7 PEDV PEDV NNP cord-254317-n2knqj4z 70 8 nucleocapsid nucleocapsid NN cord-254317-n2knqj4z 70 9 ( ( -LRB- cord-254317-n2knqj4z 70 10 N N NNP cord-254317-n2knqj4z 70 11 ) ) -RRB- cord-254317-n2knqj4z 70 12 protein protein NN cord-254317-n2knqj4z 70 13 was be VBD cord-254317-n2knqj4z 70 14 provided provide VBN cord-254317-n2knqj4z 70 15 by by IN cord-254317-n2knqj4z 70 16 Drs Drs NNP cord-254317-n2knqj4z 70 17 . . . cord-254317-n2knqj4z 71 1 Eric Eric NNP cord-254317-n2knqj4z 71 2 Nelson Nelson NNP cord-254317-n2knqj4z 71 3 and and CC cord-254317-n2knqj4z 71 4 Steven Steven NNP cord-254317-n2knqj4z 71 5 Lawson Lawson NNP cord-254317-n2knqj4z 71 6 , , , cord-254317-n2knqj4z 71 7 South South NNP cord-254317-n2knqj4z 71 8 Dakota Dakota NNP cord-254317-n2knqj4z 71 9 State State NNP cord-254317-n2knqj4z 71 10 University University NNP cord-254317-n2knqj4z 71 11 . . . cord-254317-n2knqj4z 72 1 The the DT cord-254317-n2knqj4z 72 2 guinea guinea NN cord-254317-n2knqj4z 72 3 pig pig NN cord-254317-n2knqj4z 72 4 polyclonal polyclonal JJ cord-254317-n2knqj4z 72 5 antibody antibody NN cord-254317-n2knqj4z 72 6 ( ( -LRB- cord-254317-n2knqj4z 72 7 PAb PAb NNS cord-254317-n2knqj4z 72 8 ) ) -RRB- cord-254317-n2knqj4z 73 1 GP17 GP17 NNS cord-254317-n2knqj4z 73 2 targeting target VBG cord-254317-n2knqj4z 73 3 the the DT cord-254317-n2knqj4z 73 4 S1 S1 NNP cord-254317-n2knqj4z 73 5 subunit subunit NN cord-254317-n2knqj4z 73 6 of of IN cord-254317-n2knqj4z 73 7 the the DT cord-254317-n2knqj4z 73 8 S S NNP cord-254317-n2knqj4z 73 9 protein protein NN cord-254317-n2knqj4z 73 10 of of IN cord-254317-n2knqj4z 73 11 PEDV PEDV NNP cord-254317-n2knqj4z 73 12 PC177 PC177 NNP cord-254317-n2knqj4z 73 13 strain strain NN cord-254317-n2knqj4z 73 14 ( ( -LRB- cord-254317-n2knqj4z 73 15 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 73 16 ) ) -RRB- cord-254317-n2knqj4z 73 17 ( ( -LRB- cord-254317-n2knqj4z 73 18 Fig Fig NNP cord-254317-n2knqj4z 73 19 . . . cord-254317-n2knqj4z 73 20 S1A s1a NN cord-254317-n2knqj4z 73 21 ) ) -RRB- cord-254317-n2knqj4z 73 22 , , , cord-254317-n2knqj4z 73 23 rabbit rabbit NN cord-254317-n2knqj4z 73 24 PAb PAb NNS cord-254317-n2knqj4z 73 25 RB9 RB9 NNP cord-254317-n2knqj4z 73 26 targeting target VBG cord-254317-n2knqj4z 73 27 PEDV PEDV NNP cord-254317-n2knqj4z 73 28 N N NNP cord-254317-n2knqj4z 73 29 protein protein NN cord-254317-n2knqj4z 73 30 and and CC cord-254317-n2knqj4z 73 31 swine swine NN cord-254317-n2knqj4z 73 32 PEDV PEDV NNP cord-254317-n2knqj4z 73 33 - - HYPH cord-254317-n2knqj4z 73 34 positive positive JJ cord-254317-n2knqj4z 73 35 serum serum NN cord-254317-n2knqj4z 73 36 ( ( -LRB- cord-254317-n2knqj4z 73 37 virus virus NN cord-254317-n2knqj4z 73 38 neutralization neutralization NN cord-254317-n2knqj4z 73 39 titer titer NN cord-254317-n2knqj4z 73 40 1:1024 1:1024 CD cord-254317-n2knqj4z 73 41 ) ) -RRB- cord-254317-n2knqj4z 73 42 were be VBD cord-254317-n2knqj4z 73 43 generated generate VBN cord-254317-n2knqj4z 73 44 by by IN cord-254317-n2knqj4z 73 45 our -PRON- PRP$ cord-254317-n2knqj4z 73 46 laboratory laboratory NN cord-254317-n2knqj4z 73 47 previously previously RB cord-254317-n2knqj4z 74 1 ( ( -LRB- cord-254317-n2knqj4z 74 2 Hou Hou NNP cord-254317-n2knqj4z 74 3 et et NNP cord-254317-n2knqj4z 74 4 al al NNP cord-254317-n2knqj4z 74 5 . . NNP cord-254317-n2knqj4z 74 6 , , , cord-254317-n2knqj4z 74 7 2019 2019 CD cord-254317-n2knqj4z 74 8 ) ) -RRB- cord-254317-n2knqj4z 74 9 . . . cord-254317-n2knqj4z 75 1 2.2 2.2 CD cord-254317-n2knqj4z 75 2 . . . cord-254317-n2knqj4z 76 1 Duplex Duplex NNP cord-254317-n2knqj4z 76 2 RT RT NNP cord-254317-n2knqj4z 76 3 - - HYPH cord-254317-n2knqj4z 76 4 qPCR qpcr NN cord-254317-n2knqj4z 76 5 method method NN cord-254317-n2knqj4z 76 6 for for IN cord-254317-n2knqj4z 76 7 the the DT cord-254317-n2knqj4z 76 8 detection detection NN cord-254317-n2knqj4z 76 9 and and CC cord-254317-n2knqj4z 76 10 differentiation differentiation NN cord-254317-n2knqj4z 76 11 of of IN cord-254317-n2knqj4z 76 12 PEDV PEDV NNP cord-254317-n2knqj4z 76 13 icPC22A icPC22A NNP cord-254317-n2knqj4z 76 14 and and CC cord-254317-n2knqj4z 76 15 icPC22A icPC22A NNP cord-254317-n2knqj4z 76 16 - - HYPH cord-254317-n2knqj4z 76 17 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 77 1 Based base VBN cord-254317-n2knqj4z 77 2 on on IN cord-254317-n2knqj4z 77 3 the the DT cord-254317-n2knqj4z 77 4 nucleotide nucleotide JJ cord-254317-n2knqj4z 77 5 sequence sequence NN cord-254317-n2knqj4z 77 6 differences difference NNS cord-254317-n2knqj4z 77 7 in in IN cord-254317-n2knqj4z 77 8 the the DT cord-254317-n2knqj4z 77 9 S1 S1 NNP cord-254317-n2knqj4z 77 10 NTD NTD NNP cord-254317-n2knqj4z 77 11 coding code VBG cord-254317-n2knqj4z 77 12 region region NN cord-254317-n2knqj4z 77 13 between between IN cord-254317-n2knqj4z 77 14 the the DT cord-254317-n2knqj4z 77 15 icPC22 icPC22 NNP cord-254317-n2knqj4z 77 16 A a NN cord-254317-n2knqj4z 77 17 and and CC cord-254317-n2knqj4z 77 18 icPC22 icpc22 NN cord-254317-n2knqj4z 78 1 A a LS cord-254317-n2knqj4z 78 2 - - HYPH cord-254317-n2knqj4z 78 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 78 4 , , , cord-254317-n2knqj4z 78 5 a a DT cord-254317-n2knqj4z 78 6 duplex duplex JJ cord-254317-n2knqj4z 78 7 TaqMan TaqMan NNP cord-254317-n2knqj4z 78 8 real real JJ cord-254317-n2knqj4z 78 9 - - HYPH cord-254317-n2knqj4z 78 10 time time NN cord-254317-n2knqj4z 78 11 reverse reverse NN cord-254317-n2knqj4z 78 12 - - HYPH cord-254317-n2knqj4z 78 13 transcription transcription NN cord-254317-n2knqj4z 78 14 quantitative quantitative JJ cord-254317-n2knqj4z 78 15 PCR PCR NNP cord-254317-n2knqj4z 78 16 ( ( -LRB- cord-254317-n2knqj4z 78 17 RT RT NNP cord-254317-n2knqj4z 78 18 - - HYPH cord-254317-n2knqj4z 78 19 qPCR qPCR NNP cord-254317-n2knqj4z 78 20 ) ) -RRB- cord-254317-n2knqj4z 78 21 was be VBD cord-254317-n2knqj4z 78 22 developed develop VBN cord-254317-n2knqj4z 78 23 . . . cord-254317-n2knqj4z 79 1 We -PRON- PRP cord-254317-n2knqj4z 79 2 designed design VBD cord-254317-n2knqj4z 79 3 the the DT cord-254317-n2knqj4z 79 4 primers primer NNS cord-254317-n2knqj4z 79 5 and and CC cord-254317-n2knqj4z 79 6 probes probe NNS cord-254317-n2knqj4z 79 7 ( ( -LRB- cord-254317-n2knqj4z 79 8 Table table NN cord-254317-n2knqj4z 79 9 1 1 CD cord-254317-n2knqj4z 79 10 , , , cord-254317-n2knqj4z 79 11 Fig Fig NNP cord-254317-n2knqj4z 79 12 . . . cord-254317-n2knqj4z 80 1 S1B s1b LS cord-254317-n2knqj4z 80 2 ) ) -RRB- cord-254317-n2knqj4z 81 1 and and CC cord-254317-n2knqj4z 81 2 had have VBD cord-254317-n2knqj4z 81 3 them -PRON- PRP cord-254317-n2knqj4z 81 4 synthesized synthesize VBN cord-254317-n2knqj4z 81 5 by by IN cord-254317-n2knqj4z 81 6 Integrated Integrated NNP cord-254317-n2knqj4z 81 7 DNA DNA NNP cord-254317-n2knqj4z 81 8 Technologies Technologies NNP cord-254317-n2knqj4z 81 9 ( ( -LRB- cord-254317-n2knqj4z 81 10 Skokie Skokie NNP cord-254317-n2knqj4z 81 11 , , , cord-254317-n2knqj4z 81 12 IL IL NNP cord-254317-n2knqj4z 81 13 , , , cord-254317-n2knqj4z 81 14 USA USA NNP cord-254317-n2knqj4z 81 15 ) ) -RRB- cord-254317-n2knqj4z 81 16 . . . cord-254317-n2knqj4z 82 1 The the DT cord-254317-n2knqj4z 82 2 RNA RNA NNP cord-254317-n2knqj4z 82 3 of of IN cord-254317-n2knqj4z 82 4 the the DT cord-254317-n2knqj4z 82 5 two two CD cord-254317-n2knqj4z 82 6 viruses virus NNS cord-254317-n2knqj4z 82 7 was be VBD cord-254317-n2knqj4z 82 8 extracted extract VBN cord-254317-n2knqj4z 82 9 using use VBG cord-254317-n2knqj4z 82 10 RNeasy RNeasy NNP cord-254317-n2knqj4z 82 11 Mini Mini NNP cord-254317-n2knqj4z 82 12 Kit kit NN cord-254317-n2knqj4z 82 13 ( ( -LRB- cord-254317-n2knqj4z 82 14 QIAGEN QIAGEN NNP cord-254317-n2knqj4z 82 15 , , , cord-254317-n2knqj4z 82 16 Valencia Valencia NNP cord-254317-n2knqj4z 82 17 , , , cord-254317-n2knqj4z 82 18 CA CA NNP cord-254317-n2knqj4z 82 19 , , , cord-254317-n2knqj4z 82 20 USA USA NNP cord-254317-n2knqj4z 82 21 ) ) -RRB- cord-254317-n2knqj4z 82 22 . . . cord-254317-n2knqj4z 83 1 To to TO cord-254317-n2knqj4z 83 2 generate generate VB cord-254317-n2knqj4z 83 3 a a DT cord-254317-n2knqj4z 83 4 standard standard JJ cord-254317-n2knqj4z 83 5 DNA dna NN cord-254317-n2knqj4z 83 6 , , , cord-254317-n2knqj4z 83 7 a a DT cord-254317-n2knqj4z 83 8 kit kit NN cord-254317-n2knqj4z 83 9 of of IN cord-254317-n2knqj4z 83 10 SuperScript SuperScript NNP cord-254317-n2knqj4z 83 11 ™ ™ NN cord-254317-n2knqj4z 83 12 III iii CD cord-254317-n2knqj4z 83 13 First First NNP cord-254317-n2knqj4z 83 14 - - HYPH cord-254317-n2knqj4z 83 15 Strand Strand NNP cord-254317-n2knqj4z 83 16 Synthesis Synthesis NNP cord-254317-n2knqj4z 83 17 SuperMix SuperMix NNP cord-254317-n2knqj4z 84 1 ( ( -LRB- cord-254317-n2knqj4z 84 2 Thermo Thermo NNP cord-254317-n2knqj4z 84 3 Fisher Fisher NNP cord-254317-n2knqj4z 84 4 Scientific Scientific NNP cord-254317-n2knqj4z 84 5 , , , cord-254317-n2knqj4z 84 6 Carlsbad Carlsbad NNP cord-254317-n2knqj4z 84 7 , , , cord-254317-n2knqj4z 84 8 CA CA NNP cord-254317-n2knqj4z 84 9 , , , cord-254317-n2knqj4z 84 10 USA USA NNP cord-254317-n2knqj4z 84 11 ) ) -RRB- cord-254317-n2knqj4z 84 12 was be VBD cord-254317-n2knqj4z 84 13 used use VBN cord-254317-n2knqj4z 84 14 for for IN cord-254317-n2knqj4z 84 15 cDNA cdna NN cord-254317-n2knqj4z 84 16 synthesis synthesis NN cord-254317-n2knqj4z 84 17 following follow VBG cord-254317-n2knqj4z 84 18 manufacturer manufacturer NN cord-254317-n2knqj4z 84 19 's 's POS cord-254317-n2knqj4z 84 20 instructions instruction NNS cord-254317-n2knqj4z 84 21 . . . cord-254317-n2knqj4z 85 1 Primer primer NN cord-254317-n2knqj4z 85 2 set set VBN cord-254317-n2knqj4z 85 3 PEDV-20320F PEDV-20320F NNP cord-254317-n2knqj4z 85 4 and and CC cord-254317-n2knqj4z 85 5 PEDV-21816R PEDV-21816R NNP cord-254317-n2knqj4z 86 1 ( ( -LRB- cord-254317-n2knqj4z 86 2 Oka Oka NNP cord-254317-n2knqj4z 86 3 et et NNP cord-254317-n2knqj4z 86 4 al al NNP cord-254317-n2knqj4z 86 5 . . . cord-254317-n2knqj4z 87 1 , , , cord-254317-n2knqj4z 87 2 2014 2014 CD cord-254317-n2knqj4z 87 3 ) ) -RRB- cord-254317-n2knqj4z 87 4 was be VBD cord-254317-n2knqj4z 87 5 used use VBN cord-254317-n2knqj4z 87 6 to to TO cord-254317-n2knqj4z 87 7 amplify amplify VB cord-254317-n2knqj4z 87 8 a a DT cord-254317-n2knqj4z 87 9 1.5 1.5 CD cord-254317-n2knqj4z 87 10 kb kb NNS cord-254317-n2knqj4z 87 11 or or CC cord-254317-n2knqj4z 87 12 a a DT cord-254317-n2knqj4z 87 13 0.9 0.9 CD cord-254317-n2knqj4z 87 14 kb kb NNP cord-254317-n2knqj4z 87 15 fragment fragment NN cord-254317-n2knqj4z 87 16 covering cover VBG cord-254317-n2knqj4z 87 17 PEDV PEDV NNP cord-254317-n2knqj4z 87 18 partial partial JJ cord-254317-n2knqj4z 87 19 nsp16 nsp16 NNS cord-254317-n2knqj4z 87 20 gene gene NN cord-254317-n2knqj4z 87 21 and and CC cord-254317-n2knqj4z 87 22 S1 s1 NN cord-254317-n2knqj4z 87 23 gene gene NN cord-254317-n2knqj4z 87 24 of of IN cord-254317-n2knqj4z 87 25 icPC22 icPC22 NNP cord-254317-n2knqj4z 87 26 A a NN cord-254317-n2knqj4z 87 27 and and CC cord-254317-n2knqj4z 87 28 icPC22 icpc22 NN cord-254317-n2knqj4z 88 1 A a LS cord-254317-n2knqj4z 88 2 - - HYPH cord-254317-n2knqj4z 88 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 88 4 , , , cord-254317-n2knqj4z 88 5 respectively respectively RB cord-254317-n2knqj4z 88 6 . . . cord-254317-n2knqj4z 89 1 The the DT cord-254317-n2knqj4z 89 2 PCR PCR NNP cord-254317-n2knqj4z 89 3 products product NNS cord-254317-n2knqj4z 89 4 were be VBD cord-254317-n2knqj4z 89 5 purified purify VBN cord-254317-n2knqj4z 89 6 using use VBG cord-254317-n2knqj4z 89 7 Gel Gel NNP cord-254317-n2knqj4z 89 8 Extraction Extraction NNP cord-254317-n2knqj4z 89 9 Kit kit NN cord-254317-n2knqj4z 89 10 ( ( -LRB- cord-254317-n2knqj4z 89 11 QIAGEN QIAGEN NNP cord-254317-n2knqj4z 89 12 ) ) -RRB- cord-254317-n2knqj4z 89 13 and and CC cord-254317-n2knqj4z 89 14 used use VBD cord-254317-n2knqj4z 89 15 as as IN cord-254317-n2knqj4z 89 16 standard standard JJ cord-254317-n2knqj4z 89 17 DNA dna NN cord-254317-n2knqj4z 89 18 . . . cord-254317-n2knqj4z 90 1 The the DT cord-254317-n2knqj4z 90 2 reaction reaction NN cord-254317-n2knqj4z 90 3 consisted consist VBD cord-254317-n2knqj4z 90 4 with with IN cord-254317-n2knqj4z 90 5 4 4 CD cord-254317-n2knqj4z 90 6 μL μl CD cord-254317-n2knqj4z 90 7 5 5 CD cord-254317-n2knqj4z 90 8 × × NN cord-254317-n2knqj4z 90 9 PCR PCR NNP cord-254317-n2knqj4z 90 10 Buffer Buffer NNP cord-254317-n2knqj4z 90 11 , , , cord-254317-n2knqj4z 90 12 0.8 0.8 CD cord-254317-n2knqj4z 90 13 μL μL . cord-254317-n2knqj4z 91 1 10 10 CD cord-254317-n2knqj4z 91 2 mM mm CD cord-254317-n2knqj4z 91 3 dNTPs dntps CD cord-254317-n2knqj4z 91 4 ( ( -LRB- cord-254317-n2knqj4z 91 5 QIAGEN QIAGEN NNP cord-254317-n2knqj4z 91 6 ) ) -RRB- cord-254317-n2knqj4z 91 7 , , . cord-254317-n2knqj4z 92 1 1.2 1.2 CD cord-254317-n2knqj4z 92 2 μL μL . cord-254317-n2knqj4z 93 1 each each DT cord-254317-n2knqj4z 93 2 primer primer NN cord-254317-n2knqj4z 93 3 ( ( -LRB- cord-254317-n2knqj4z 93 4 10 10 CD cord-254317-n2knqj4z 93 5 μM μM NNP cord-254317-n2knqj4z 93 6 ) ) -RRB- cord-254317-n2knqj4z 93 7 , , . cord-254317-n2knqj4z 94 1 0.4 0.4 CD cord-254317-n2knqj4z 94 2 μL μL . cord-254317-n2knqj4z 95 1 each each DT cord-254317-n2knqj4z 95 2 probe probe NN cord-254317-n2knqj4z 95 3 ( ( -LRB- cord-254317-n2knqj4z 95 4 5 5 CD cord-254317-n2knqj4z 95 5 μM μM NNP cord-254317-n2knqj4z 95 6 ) ) -RRB- cord-254317-n2knqj4z 95 7 , , , cord-254317-n2knqj4z 95 8 0.2 0.2 CD cord-254317-n2knqj4z 95 9 μL μl NN cord-254317-n2knqj4z 95 10 RNAsin rnasin XX cord-254317-n2knqj4z 96 1 ( ( -LRB- cord-254317-n2knqj4z 96 2 PROMEGA PROMEGA NNP cord-254317-n2knqj4z 96 3 , , , cord-254317-n2knqj4z 96 4 WI WI NNP cord-254317-n2knqj4z 96 5 , , , cord-254317-n2knqj4z 96 6 USA USA NNP cord-254317-n2knqj4z 96 7 ) ) -RRB- cord-254317-n2knqj4z 96 8 , , . cord-254317-n2knqj4z 97 1 0.8 0.8 CD cord-254317-n2knqj4z 97 2 μL μL . cord-254317-n2knqj4z 98 1 Enzyme Enzyme NNP cord-254317-n2knqj4z 98 2 Mix Mix NNP cord-254317-n2knqj4z 98 3 ( ( -LRB- cord-254317-n2knqj4z 98 4 QIAGEN QIAGEN NNP cord-254317-n2knqj4z 98 5 ) ) -RRB- cord-254317-n2knqj4z 98 6 , , , cord-254317-n2knqj4z 98 7 1.6 1.6 CD cord-254317-n2knqj4z 98 8 μL μL NFP cord-254317-n2knqj4z 98 9 each each DT cord-254317-n2knqj4z 98 10 DNA DNA NNP cord-254317-n2knqj4z 98 11 / / SYM cord-254317-n2knqj4z 98 12 RNA RNA NNP cord-254317-n2knqj4z 98 13 and and CC cord-254317-n2knqj4z 98 14 6.6 6.6 CD cord-254317-n2knqj4z 98 15 μL μl CD cord-254317-n2knqj4z 98 16 sterilized sterilize VBN cord-254317-n2knqj4z 98 17 water water NN cord-254317-n2knqj4z 98 18 . . . cord-254317-n2knqj4z 99 1 The the DT cord-254317-n2knqj4z 99 2 RT RT NNP cord-254317-n2knqj4z 99 3 - - HYPH cord-254317-n2knqj4z 99 4 qPCR qpcr NN cord-254317-n2knqj4z 99 5 procedure procedure NN cord-254317-n2knqj4z 99 6 was be VBD cord-254317-n2knqj4z 99 7 : : : cord-254317-n2knqj4z 99 8 50 50 CD cord-254317-n2knqj4z 99 9 ° ° NN cord-254317-n2knqj4z 99 10 C c NN cord-254317-n2knqj4z 99 11 for for IN cord-254317-n2knqj4z 99 12 30 30 CD cord-254317-n2knqj4z 99 13 min min NN cord-254317-n2knqj4z 99 14 , , , cord-254317-n2knqj4z 99 15 95 95 CD cord-254317-n2knqj4z 99 16 ° ° NN cord-254317-n2knqj4z 99 17 C c NN cord-254317-n2knqj4z 99 18 for for IN cord-254317-n2knqj4z 99 19 15 15 CD cord-254317-n2knqj4z 99 20 min min NN cord-254317-n2knqj4z 99 21 and and CC cord-254317-n2knqj4z 99 22 45 45 CD cord-254317-n2knqj4z 99 23 cycles cycle NNS cord-254317-n2knqj4z 99 24 of of IN cord-254317-n2knqj4z 99 25 95 95 CD cord-254317-n2knqj4z 99 26 ° ° NN cord-254317-n2knqj4z 99 27 C c NN cord-254317-n2knqj4z 99 28 for for IN cord-254317-n2knqj4z 99 29 15 15 CD cord-254317-n2knqj4z 99 30 s s NNS cord-254317-n2knqj4z 99 31 and and CC cord-254317-n2knqj4z 99 32 60 60 CD cord-254317-n2knqj4z 99 33 ° ° NN cord-254317-n2knqj4z 99 34 C c NN cord-254317-n2knqj4z 99 35 for for IN cord-254317-n2knqj4z 99 36 60 60 CD cord-254317-n2knqj4z 99 37 s. s. NN cord-254317-n2knqj4z 100 1 We -PRON- PRP cord-254317-n2knqj4z 100 2 generated generate VBD cord-254317-n2knqj4z 100 3 two two CD cord-254317-n2knqj4z 100 4 standard standard JJ cord-254317-n2knqj4z 100 5 curves curve NNS cord-254317-n2knqj4z 100 6 using use VBG cord-254317-n2knqj4z 101 1 Light Light NNP cord-254317-n2knqj4z 101 2 - - HYPH cord-254317-n2knqj4z 101 3 Cycler Cycler NNP cord-254317-n2knqj4z 101 4 ® ® . cord-254317-n2knqj4z 101 5 96 96 CD cord-254317-n2knqj4z 101 6 System system NN cord-254317-n2knqj4z 101 7 ( ( -LRB- cord-254317-n2knqj4z 101 8 Roche Roche NNP cord-254317-n2knqj4z 101 9 Life Life NNP cord-254317-n2knqj4z 101 10 Science Science NNP cord-254317-n2knqj4z 101 11 , , , cord-254317-n2knqj4z 101 12 Indianapolis Indianapolis NNP cord-254317-n2knqj4z 101 13 , , , cord-254317-n2knqj4z 101 14 IN IN NNP cord-254317-n2knqj4z 101 15 , , , cord-254317-n2knqj4z 101 16 USA USA NNP cord-254317-n2knqj4z 101 17 ) ) -RRB- cord-254317-n2knqj4z 101 18 . . . cord-254317-n2knqj4z 102 1 The the DT cord-254317-n2knqj4z 102 2 two two CD cord-254317-n2knqj4z 102 3 standard standard JJ cord-254317-n2knqj4z 102 4 curves curve NNS cord-254317-n2knqj4z 102 5 for for IN cord-254317-n2knqj4z 102 6 the the DT cord-254317-n2knqj4z 102 7 serially serially RB cord-254317-n2knqj4z 102 8 diluted dilute VBN cord-254317-n2knqj4z 102 9 DNA dna NN cord-254317-n2knqj4z 102 10 fragments fragment NNS cord-254317-n2knqj4z 102 11 of of IN cord-254317-n2knqj4z 102 12 icPC22A icPC22A NNP cord-254317-n2knqj4z 102 13 and and CC cord-254317-n2knqj4z 102 14 icPC22A icPC22A NNP cord-254317-n2knqj4z 102 15 - - HYPH cord-254317-n2knqj4z 102 16 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 102 17 showed show VBD cord-254317-n2knqj4z 102 18 regressions regression NNS cord-254317-n2knqj4z 102 19 with with IN cord-254317-n2knqj4z 102 20 coefficients coefficient NNS cord-254317-n2knqj4z 102 21 of of IN cord-254317-n2knqj4z 102 22 -0.2873 -0.2873 NN cord-254317-n2knqj4z 102 23 and and CC cord-254317-n2knqj4z 102 24 -3.009 -3.009 NNP cord-254317-n2knqj4z 102 25 , , , cord-254317-n2knqj4z 102 26 respectively respectively RB cord-254317-n2knqj4z 102 27 , , , cord-254317-n2knqj4z 102 28 and and CC cord-254317-n2knqj4z 102 29 the the DT cord-254317-n2knqj4z 102 30 corresponding correspond VBG cord-254317-n2knqj4z 102 31 correlation correlation NN cord-254317-n2knqj4z 102 32 coefficient coefficient NN cord-254317-n2knqj4z 102 33 ( ( -LRB- cord-254317-n2knqj4z 102 34 R R NNP cord-254317-n2knqj4z 102 35 2 2 CD cord-254317-n2knqj4z 102 36 ) ) -RRB- cord-254317-n2knqj4z 102 37 of of IN cord-254317-n2knqj4z 102 38 0.9987 0.9987 CD cord-254317-n2knqj4z 102 39 and and CC cord-254317-n2knqj4z 102 40 0.9963 0.9963 CD cord-254317-n2knqj4z 102 41 , , , cord-254317-n2knqj4z 102 42 respectively respectively RB cord-254317-n2knqj4z 102 43 . . . cord-254317-n2knqj4z 103 1 The the DT cord-254317-n2knqj4z 103 2 primers primer NNS cord-254317-n2knqj4z 103 3 and and CC cord-254317-n2knqj4z 103 4 probes probe NNS cord-254317-n2knqj4z 103 5 were be VBD cord-254317-n2knqj4z 103 6 further further RB cord-254317-n2knqj4z 103 7 tested test VBN cord-254317-n2knqj4z 103 8 using use VBG cord-254317-n2knqj4z 103 9 individual individual NN cord-254317-n2knqj4z 103 10 and and CC cord-254317-n2knqj4z 103 11 the the DT cord-254317-n2knqj4z 103 12 mixture mixture NN cord-254317-n2knqj4z 103 13 of of IN cord-254317-n2knqj4z 103 14 two two CD cord-254317-n2knqj4z 103 15 viruses virus NNS cord-254317-n2knqj4z 103 16 . . . cord-254317-n2knqj4z 104 1 We -PRON- PRP cord-254317-n2knqj4z 104 2 tested test VBD cord-254317-n2knqj4z 104 3 the the DT cord-254317-n2knqj4z 104 4 correlation correlation NN cord-254317-n2knqj4z 104 5 between between IN cord-254317-n2knqj4z 104 6 S S NNP cord-254317-n2knqj4z 104 7 gene gene NN cord-254317-n2knqj4z 104 8 titers titer NNS cord-254317-n2knqj4z 104 9 and and CC cord-254317-n2knqj4z 104 10 infectious infectious JJ cord-254317-n2knqj4z 104 11 titers titer NNS cord-254317-n2knqj4z 104 12 of of IN cord-254317-n2knqj4z 104 13 PEDV PEDV NNP cord-254317-n2knqj4z 104 14 icPC22 icpc22 NN cord-254317-n2knqj4z 105 1 A a NN cord-254317-n2knqj4z 105 2 and and CC cord-254317-n2knqj4z 105 3 icPC22 icpc22 NN cord-254317-n2knqj4z 106 1 A a LS cord-254317-n2knqj4z 106 2 - - HYPH cord-254317-n2knqj4z 106 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 106 4 using use VBG cord-254317-n2knqj4z 106 5 serially serially RB cord-254317-n2knqj4z 106 6 diluted dilute VBN cord-254317-n2knqj4z 106 7 , , , cord-254317-n2knqj4z 106 8 cell cell NN cord-254317-n2knqj4z 106 9 cultured cultured JJ cord-254317-n2knqj4z 106 10 viruses virus NNS cord-254317-n2knqj4z 106 11 ( ( -LRB- cord-254317-n2knqj4z 106 12 Table Table NNP cord-254317-n2knqj4z 106 13 S1 S1 NNP cord-254317-n2knqj4z 106 14 and and CC cord-254317-n2knqj4z 106 15 S2 S2 NNP cord-254317-n2knqj4z 106 16 ) ) -RRB- cord-254317-n2knqj4z 106 17 . . . cord-254317-n2knqj4z 107 1 For for IN cord-254317-n2knqj4z 107 2 the the DT cord-254317-n2knqj4z 107 3 samples sample NNS cord-254317-n2knqj4z 107 4 of of IN cord-254317-n2knqj4z 107 5 mixed mixed JJ cord-254317-n2knqj4z 107 6 viruses virus NNS cord-254317-n2knqj4z 107 7 , , , cord-254317-n2knqj4z 107 8 the the DT cord-254317-n2knqj4z 107 9 duplex duplex JJ cord-254317-n2knqj4z 107 10 RT RT NNP cord-254317-n2knqj4z 107 11 - - HYPH cord-254317-n2knqj4z 107 12 qPCR qPCR NNP cord-254317-n2knqj4z 107 13 was be VBD cord-254317-n2knqj4z 107 14 performed perform VBN cord-254317-n2knqj4z 107 15 to to TO cord-254317-n2knqj4z 107 16 differentiate differentiate VB cord-254317-n2knqj4z 107 17 the the DT cord-254317-n2knqj4z 107 18 S S NNP cord-254317-n2knqj4z 107 19 gene gene NN cord-254317-n2knqj4z 107 20 of of IN cord-254317-n2knqj4z 107 21 each each DT cord-254317-n2knqj4z 107 22 virus virus NN cord-254317-n2knqj4z 107 23 . . . cord-254317-n2knqj4z 108 1 The the DT cord-254317-n2knqj4z 108 2 detection detection NN cord-254317-n2knqj4z 108 3 limit limit NN cord-254317-n2knqj4z 108 4 was be VBD cord-254317-n2knqj4z 108 5 5 5 CD cord-254317-n2knqj4z 108 6 log log NN cord-254317-n2knqj4z 108 7 10 10 CD cord-254317-n2knqj4z 108 8 S s NN cord-254317-n2knqj4z 108 9 gene gene NN cord-254317-n2knqj4z 108 10 copies copy NNS cord-254317-n2knqj4z 108 11 / / SYM cord-254317-n2knqj4z 108 12 mL ml NN cord-254317-n2knqj4z 108 13 for for IN cord-254317-n2knqj4z 108 14 both both DT cord-254317-n2knqj4z 108 15 icPC22 icPC22 NNP cord-254317-n2knqj4z 108 16 A a NN cord-254317-n2knqj4z 108 17 and and CC cord-254317-n2knqj4z 108 18 icPC22 icpc22 NN cord-254317-n2knqj4z 109 1 A a LS cord-254317-n2knqj4z 109 2 - - HYPH cord-254317-n2knqj4z 109 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 109 4 . . . cord-254317-n2knqj4z 110 1 The the DT cord-254317-n2knqj4z 110 2 Gn Gn NNP cord-254317-n2knqj4z 110 3 piglets piglet NNS cord-254317-n2knqj4z 110 4 were be VBD cord-254317-n2knqj4z 110 5 derived derive VBN cord-254317-n2knqj4z 110 6 and and CC cord-254317-n2knqj4z 110 7 raised raise VBN cord-254317-n2knqj4z 110 8 as as IN cord-254317-n2knqj4z 110 9 described describe VBN cord-254317-n2knqj4z 110 10 previously previously RB cord-254317-n2knqj4z 110 11 ( ( -LRB- cord-254317-n2knqj4z 110 12 Saif Saif NNP cord-254317-n2knqj4z 110 13 et et FW cord-254317-n2knqj4z 110 14 al al NNP cord-254317-n2knqj4z 110 15 . . NNP cord-254317-n2knqj4z 110 16 , , , cord-254317-n2knqj4z 110 17 1996 1996 CD cord-254317-n2knqj4z 110 18 ) ) -RRB- cord-254317-n2knqj4z 110 19 . . . cord-254317-n2knqj4z 111 1 Thirty thirty CD cord-254317-n2knqj4z 111 2 - - HYPH cord-254317-n2knqj4z 111 3 one one CD cord-254317-n2knqj4z 111 4 Gn Gn NNP cord-254317-n2knqj4z 111 5 piglets piglet NNS cord-254317-n2knqj4z 111 6 were be VBD cord-254317-n2knqj4z 111 7 assigned assign VBN cord-254317-n2knqj4z 111 8 to to IN cord-254317-n2knqj4z 111 9 five five CD cord-254317-n2knqj4z 111 10 experimental experimental JJ cord-254317-n2knqj4z 111 11 groups group NNS cord-254317-n2knqj4z 111 12 : : : cord-254317-n2knqj4z 111 13 ( ( -LRB- cord-254317-n2knqj4z 111 14 1 1 LS cord-254317-n2knqj4z 111 15 ) ) -RRB- cord-254317-n2knqj4z 111 16 icPC22 icPC22 . cord-254317-n2knqj4z 112 1 A a DT cord-254317-n2knqj4z 112 2 ( ( -LRB- cord-254317-n2knqj4z 112 3 n n NN cord-254317-n2knqj4z 112 4 = = SYM cord-254317-n2knqj4z 112 5 14 14 CD cord-254317-n2knqj4z 112 6 ; ; : cord-254317-n2knqj4z 112 7 100 100 CD cord-254317-n2knqj4z 112 8 PFU pfu NN cord-254317-n2knqj4z 112 9 / / SYM cord-254317-n2knqj4z 112 10 pig pig NN cord-254317-n2knqj4z 112 11 ) ) -RRB- cord-254317-n2knqj4z 112 12 ; ; : cord-254317-n2knqj4z 112 13 ( ( -LRB- cord-254317-n2knqj4z 112 14 2 2 LS cord-254317-n2knqj4z 112 15 ) ) -RRB- cord-254317-n2knqj4z 112 16 icPC22A icPC22A NNP cord-254317-n2knqj4z 112 17 - - HYPH cord-254317-n2knqj4z 112 18 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 112 19 ( ( -LRB- cord-254317-n2knqj4z 112 20 n n NN cord-254317-n2knqj4z 112 21 = = SYM cord-254317-n2knqj4z 112 22 7 7 CD cord-254317-n2knqj4z 112 23 ; ; : cord-254317-n2knqj4z 112 24 100 100 CD cord-254317-n2knqj4z 112 25 PFU pfu NN cord-254317-n2knqj4z 112 26 / / SYM cord-254317-n2knqj4z 112 27 pig pig NN cord-254317-n2knqj4z 112 28 ) ) -RRB- cord-254317-n2knqj4z 112 29 ; ; : cord-254317-n2knqj4z 113 1 ( ( -LRB- cord-254317-n2knqj4z 113 2 3 3 LS cord-254317-n2knqj4z 113 3 ) ) -RRB- cord-254317-n2knqj4z 113 4 Coinfection Coinfection NNP cord-254317-n2knqj4z 113 5 of of IN cord-254317-n2knqj4z 113 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 113 7 and and CC cord-254317-n2knqj4z 113 8 icPC22 icpc22 NN cord-254317-n2knqj4z 114 1 A a LS cord-254317-n2knqj4z 114 2 - - HYPH cord-254317-n2knqj4z 114 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 114 4 ( ( -LRB- cord-254317-n2knqj4z 114 5 n n NN cord-254317-n2knqj4z 114 6 = = SYM cord-254317-n2knqj4z 114 7 7 7 CD cord-254317-n2knqj4z 114 8 ; ; : cord-254317-n2knqj4z 114 9 100 100 CD cord-254317-n2knqj4z 114 10 PFU pfu NN cord-254317-n2knqj4z 114 11 / / SYM cord-254317-n2knqj4z 114 12 pig pig NN cord-254317-n2knqj4z 114 13 of of IN cord-254317-n2knqj4z 114 14 each each DT cord-254317-n2knqj4z 114 15 virus virus NN cord-254317-n2knqj4z 114 16 ) ) -RRB- cord-254317-n2knqj4z 114 17 ; ; . cord-254317-n2knqj4z 115 1 ( ( -LRB- cord-254317-n2knqj4z 115 2 4 4 LS cord-254317-n2knqj4z 115 3 ) ) -RRB- cord-254317-n2knqj4z 115 4 Mock mock VB cord-254317-n2knqj4z 115 5 ( ( -LRB- cord-254317-n2knqj4z 115 6 n n NN cord-254317-n2knqj4z 115 7 = = SYM cord-254317-n2knqj4z 115 8 2 2 CD cord-254317-n2knqj4z 115 9 ; ; : cord-254317-n2knqj4z 115 10 PBS PBS NNP cord-254317-n2knqj4z 115 11 ) ) -RRB- cord-254317-n2knqj4z 115 12 ; ; : cord-254317-n2knqj4z 115 13 ( ( -LRB- cord-254317-n2knqj4z 115 14 5 5 LS cord-254317-n2knqj4z 115 15 ) ) -RRB- cord-254317-n2knqj4z 116 1 Second second JJ cord-254317-n2knqj4z 116 2 passage passage NN cord-254317-n2knqj4z 116 3 of of IN cord-254317-n2knqj4z 116 4 coinfection coinfection NN cord-254317-n2knqj4z 116 5 [ [ -LRB- cord-254317-n2knqj4z 116 6 n n NN cord-254317-n2knqj4z 116 7 = = SYM cord-254317-n2knqj4z 116 8 1 1 CD cord-254317-n2knqj4z 116 9 ; ; , cord-254317-n2knqj4z 116 10 small small JJ cord-254317-n2knqj4z 116 11 intestinal intestinal JJ cord-254317-n2knqj4z 116 12 contents content NNS cord-254317-n2knqj4z 116 13 ( ( -LRB- cord-254317-n2knqj4z 116 14 SIC sic NN cord-254317-n2knqj4z 116 15 ) ) -RRB- cord-254317-n2knqj4z 116 16 ( ( -LRB- cord-254317-n2knqj4z 116 17 sample sample NN cord-254317-n2knqj4z 116 18 # # NN cord-254317-n2knqj4z 116 19 PE1158 pe1158 NN cord-254317-n2knqj4z 116 20 ) ) -RRB- cord-254317-n2knqj4z 116 21 of of IN cord-254317-n2knqj4z 116 22 one one CD cord-254317-n2knqj4z 116 23 piglet piglet NN cord-254317-n2knqj4z 116 24 in in IN cord-254317-n2knqj4z 116 25 group group NN cord-254317-n2knqj4z 116 26 3 3 CD cord-254317-n2knqj4z 116 27 collected collect VBD cord-254317-n2knqj4z 116 28 at at IN cord-254317-n2knqj4z 116 29 2 2 CD cord-254317-n2knqj4z 116 30 day day NN cord-254317-n2knqj4z 116 31 post post NN cord-254317-n2knqj4z 116 32 inoculation inoculation NN cord-254317-n2knqj4z 116 33 ( ( -LRB- cord-254317-n2knqj4z 116 34 dpi dpi NNP cord-254317-n2knqj4z 116 35 ) ) -RRB- cord-254317-n2knqj4z 116 36 , , , cord-254317-n2knqj4z 116 37 at at IN cord-254317-n2knqj4z 116 38 a a DT cord-254317-n2knqj4z 116 39 dose dose NN cord-254317-n2knqj4z 116 40 of of IN cord-254317-n2knqj4z 116 41 10 10 CD cord-254317-n2knqj4z 116 42 log log NN cord-254317-n2knqj4z 116 43 10 10 CD cord-254317-n2knqj4z 116 44 copies copy NNS cord-254317-n2knqj4z 116 45 / / SYM cord-254317-n2knqj4z 116 46 mL ml NN cord-254317-n2knqj4z 116 47 based base VBN cord-254317-n2knqj4z 116 48 on on IN cord-254317-n2knqj4z 116 49 the the DT cord-254317-n2knqj4z 116 50 N n CD cord-254317-n2knqj4z 116 51 gene gene NN cord-254317-n2knqj4z 116 52 , , , cord-254317-n2knqj4z 116 53 9 9 CD cord-254317-n2knqj4z 116 54 log log NN cord-254317-n2knqj4z 117 1 10 10 CD cord-254317-n2knqj4z 117 2 copies copy NNS cord-254317-n2knqj4z 117 3 / / SYM cord-254317-n2knqj4z 117 4 mL ml NN cord-254317-n2knqj4z 117 5 and and CC cord-254317-n2knqj4z 117 6 7 7 CD cord-254317-n2knqj4z 117 7 log log VBP cord-254317-n2knqj4z 117 8 10 10 CD cord-254317-n2knqj4z 117 9 copies copy NNS cord-254317-n2knqj4z 117 10 / / SYM cord-254317-n2knqj4z 117 11 mL ml NN cord-254317-n2knqj4z 118 1 based base VBN cord-254317-n2knqj4z 118 2 on on IN cord-254317-n2knqj4z 118 3 the the DT cord-254317-n2knqj4z 118 4 icPC22A icPC22A NNP cord-254317-n2knqj4z 118 5 - - HYPH cord-254317-n2knqj4z 118 6 specific specific JJ cord-254317-n2knqj4z 118 7 S S NNP cord-254317-n2knqj4z 118 8 gene gene NN cord-254317-n2knqj4z 118 9 and and CC cord-254317-n2knqj4z 119 1 icPC22A icPC22A NNP cord-254317-n2knqj4z 119 2 - - HYPH cord-254317-n2knqj4z 119 3 S1Δ197-specific s1δ197-specific XX cord-254317-n2knqj4z 120 1 S s NN cord-254317-n2knqj4z 120 2 gene gene NN cord-254317-n2knqj4z 120 3 , , , cord-254317-n2knqj4z 120 4 respectively respectively RB cord-254317-n2knqj4z 120 5 , , , cord-254317-n2knqj4z 120 6 corresponding correspond VBG cord-254317-n2knqj4z 120 7 to to IN cord-254317-n2knqj4z 120 8 4 4 CD cord-254317-n2knqj4z 120 9 Table table NN cord-254317-n2knqj4z 120 10 1 1 CD cord-254317-n2knqj4z 120 11 Primers Primers NNPS cord-254317-n2knqj4z 120 12 and and CC cord-254317-n2knqj4z 120 13 probes probe NNS cord-254317-n2knqj4z 120 14 of of IN cord-254317-n2knqj4z 120 15 the the DT cord-254317-n2knqj4z 120 16 duplex duplex JJ cord-254317-n2knqj4z 120 17 RT rt NN cord-254317-n2knqj4z 120 18 - - HYPH cord-254317-n2knqj4z 120 19 qPCR qPCR NNP cord-254317-n2knqj4z 120 20 . . . cord-254317-n2knqj4z 121 1 log log VB cord-254317-n2knqj4z 121 2 10 10 CD cord-254317-n2knqj4z 122 1 PFU pfu NN cord-254317-n2knqj4z 122 2 / / SYM cord-254317-n2knqj4z 122 3 mL ml NN cord-254317-n2knqj4z 122 4 of of IN cord-254317-n2knqj4z 122 5 infectious infectious JJ cord-254317-n2knqj4z 122 6 PEDV PEDV NNP cord-254317-n2knqj4z 122 7 ] ] -RRB- cord-254317-n2knqj4z 122 8 . . . cord-254317-n2knqj4z 123 1 At at IN cord-254317-n2knqj4z 123 2 5 5 CD cord-254317-n2knqj4z 123 3 days day NNS cord-254317-n2knqj4z 123 4 of of IN cord-254317-n2knqj4z 123 5 age age NN cord-254317-n2knqj4z 123 6 , , , cord-254317-n2knqj4z 123 7 piglets piglet NNS cord-254317-n2knqj4z 123 8 in in IN cord-254317-n2knqj4z 123 9 groups group NNS cord-254317-n2knqj4z 123 10 1 1 CD cord-254317-n2knqj4z 123 11 - - SYM cord-254317-n2knqj4z 123 12 4 4 CD cord-254317-n2knqj4z 123 13 were be VBD cord-254317-n2knqj4z 123 14 orally orally RB cord-254317-n2knqj4z 123 15 inoculated inoculate VBN cord-254317-n2knqj4z 123 16 with with IN cord-254317-n2knqj4z 123 17 individual individual JJ cord-254317-n2knqj4z 123 18 or or CC cord-254317-n2knqj4z 123 19 the the DT cord-254317-n2knqj4z 123 20 mixture mixture NN cord-254317-n2knqj4z 123 21 of of IN cord-254317-n2knqj4z 123 22 the the DT cord-254317-n2knqj4z 123 23 viruses virus NNS cord-254317-n2knqj4z 123 24 . . . cord-254317-n2knqj4z 124 1 The the DT cord-254317-n2knqj4z 124 2 group group NN cord-254317-n2knqj4z 124 3 5 5 CD cord-254317-n2knqj4z 124 4 pig pig NN cord-254317-n2knqj4z 124 5 was be VBD cord-254317-n2knqj4z 124 6 inoculated inoculate VBN cord-254317-n2knqj4z 124 7 at at IN cord-254317-n2knqj4z 124 8 12 12 CD cord-254317-n2knqj4z 124 9 days day NNS cord-254317-n2knqj4z 124 10 of of IN cord-254317-n2knqj4z 124 11 age age NN cord-254317-n2knqj4z 124 12 and and CC cord-254317-n2knqj4z 124 13 was be VBD cord-254317-n2knqj4z 124 14 euthanized euthanize VBN cord-254317-n2knqj4z 124 15 at at IN cord-254317-n2knqj4z 124 16 1 1 CD cord-254317-n2knqj4z 124 17 dpi dpi NN cord-254317-n2knqj4z 124 18 . . . cord-254317-n2knqj4z 125 1 To to TO cord-254317-n2knqj4z 125 2 examine examine VB cord-254317-n2knqj4z 125 3 histopathological histopathological JJ cord-254317-n2knqj4z 125 4 changes change NNS cord-254317-n2knqj4z 125 5 , , , cord-254317-n2knqj4z 125 6 one one CD cord-254317-n2knqj4z 125 7 or or CC cord-254317-n2knqj4z 125 8 two two CD cord-254317-n2knqj4z 125 9 piglets piglet NNS cord-254317-n2knqj4z 125 10 of of IN cord-254317-n2knqj4z 125 11 groups group NNS cord-254317-n2knqj4z 125 12 1 1 CD cord-254317-n2knqj4z 125 13 - - SYM cord-254317-n2knqj4z 125 14 4 4 CD cord-254317-n2knqj4z 125 15 were be VBD cord-254317-n2knqj4z 125 16 euthanized euthanize VBN cord-254317-n2knqj4z 125 17 at at IN cord-254317-n2knqj4z 125 18 0.5 0.5 CD cord-254317-n2knqj4z 125 19 dpi dpi NN cord-254317-n2knqj4z 125 20 and and CC cord-254317-n2knqj4z 125 21 2 2 CD cord-254317-n2knqj4z 125 22 - - SYM cord-254317-n2knqj4z 125 23 3 3 CD cord-254317-n2knqj4z 125 24 dpi dpi NN cord-254317-n2knqj4z 125 25 , , , cord-254317-n2knqj4z 125 26 respectively respectively RB cord-254317-n2knqj4z 125 27 . . . cord-254317-n2knqj4z 126 1 After after IN cord-254317-n2knqj4z 126 2 inoculation inoculation NN cord-254317-n2knqj4z 126 3 , , , cord-254317-n2knqj4z 126 4 all all DT cord-254317-n2knqj4z 126 5 piglets piglet NNS cord-254317-n2knqj4z 126 6 were be VBD cord-254317-n2knqj4z 126 7 evaluated evaluate VBN cord-254317-n2knqj4z 126 8 daily daily RB cord-254317-n2knqj4z 126 9 for for IN cord-254317-n2knqj4z 126 10 clinical clinical JJ cord-254317-n2knqj4z 126 11 signs sign NNS cord-254317-n2knqj4z 126 12 , , , cord-254317-n2knqj4z 126 13 such such JJ cord-254317-n2knqj4z 126 14 as as IN cord-254317-n2knqj4z 126 15 diarrhea diarrhea NN cord-254317-n2knqj4z 126 16 , , , cord-254317-n2knqj4z 126 17 vomiting vomiting NN cord-254317-n2knqj4z 126 18 , , , cord-254317-n2knqj4z 126 19 anorexia anorexia NN cord-254317-n2knqj4z 126 20 , , , cord-254317-n2knqj4z 126 21 and and CC cord-254317-n2knqj4z 126 22 depression depression NN cord-254317-n2knqj4z 126 23 . . . cord-254317-n2knqj4z 127 1 Fecal fecal JJ cord-254317-n2knqj4z 127 2 consistency consistency NN cord-254317-n2knqj4z 127 3 was be VBD cord-254317-n2knqj4z 127 4 examined examine VBN cord-254317-n2knqj4z 127 5 by by IN cord-254317-n2knqj4z 127 6 collecting collect VBG cord-254317-n2knqj4z 127 7 rectal rectal JJ cord-254317-n2knqj4z 127 8 swabs swab NNS cord-254317-n2knqj4z 127 9 and and CC cord-254317-n2knqj4z 127 10 scored score VBD cord-254317-n2knqj4z 127 11 as as IN cord-254317-n2knqj4z 127 12 follows follow VBZ cord-254317-n2knqj4z 127 13 : : : cord-254317-n2knqj4z 127 14 0 0 NFP cord-254317-n2knqj4z 127 15 , , , cord-254317-n2knqj4z 127 16 solid solid JJ cord-254317-n2knqj4z 127 17 ; ; : cord-254317-n2knqj4z 127 18 1 1 CD cord-254317-n2knqj4z 127 19 , , , cord-254317-n2knqj4z 127 20 pasty pasty JJ cord-254317-n2knqj4z 127 21 ; ; : cord-254317-n2knqj4z 127 22 2 2 CD cord-254317-n2knqj4z 127 23 , , , cord-254317-n2knqj4z 127 24 semiliquid semiliquid NNP cord-254317-n2knqj4z 127 25 ( ( -LRB- cord-254317-n2knqj4z 127 26 mild mild JJ cord-254317-n2knqj4z 127 27 diarrhea diarrhea NN cord-254317-n2knqj4z 127 28 ) ) -RRB- cord-254317-n2knqj4z 127 29 ; ; : cord-254317-n2knqj4z 127 30 and and CC cord-254317-n2knqj4z 127 31 3 3 CD cord-254317-n2knqj4z 127 32 , , , cord-254317-n2knqj4z 127 33 liquid liquid JJ cord-254317-n2knqj4z 127 34 ( ( -LRB- cord-254317-n2knqj4z 127 35 severe severe JJ cord-254317-n2knqj4z 127 36 diarrhea diarrhea NN cord-254317-n2knqj4z 127 37 ) ) -RRB- cord-254317-n2knqj4z 127 38 . . . cord-254317-n2knqj4z 128 1 Total total JJ cord-254317-n2knqj4z 128 2 fecal fecal JJ cord-254317-n2knqj4z 128 3 RNA RNA NNP cord-254317-n2knqj4z 128 4 was be VBD cord-254317-n2knqj4z 128 5 extracted extract VBN cord-254317-n2knqj4z 128 6 using use VBG cord-254317-n2knqj4z 128 7 MagMAX-96 MagMAX-96 NNP cord-254317-n2knqj4z 128 8 RNA RNA NNP cord-254317-n2knqj4z 128 9 isolation isolation NN cord-254317-n2knqj4z 128 10 kit kit NN cord-254317-n2knqj4z 128 11 ( ( -LRB- cord-254317-n2knqj4z 128 12 Thermo Thermo NNP cord-254317-n2knqj4z 128 13 Fisher Fisher NNP cord-254317-n2knqj4z 128 14 Scientific Scientific NNP cord-254317-n2knqj4z 128 15 ) ) -RRB- cord-254317-n2knqj4z 128 16 , , , cord-254317-n2knqj4z 128 17 and and CC cord-254317-n2knqj4z 128 18 the the DT cord-254317-n2knqj4z 128 19 viral viral JJ cord-254317-n2knqj4z 128 20 RNA RNA NNP cord-254317-n2knqj4z 128 21 was be VBD cord-254317-n2knqj4z 128 22 titrated titrate VBN cord-254317-n2knqj4z 128 23 by by IN cord-254317-n2knqj4z 128 24 the the DT cord-254317-n2knqj4z 128 25 RT RT NNP cord-254317-n2knqj4z 128 26 - - HYPH cord-254317-n2knqj4z 128 27 qPCR qPCR NNP cord-254317-n2knqj4z 128 28 targeting target VBG cord-254317-n2knqj4z 128 29 the the DT cord-254317-n2knqj4z 128 30 N n CD cord-254317-n2knqj4z 128 31 gene gene NN cord-254317-n2knqj4z 128 32 and and CC cord-254317-n2knqj4z 129 1 the the DT cord-254317-n2knqj4z 129 2 duplex duplex JJ cord-254317-n2knqj4z 129 3 RT RT NNP cord-254317-n2knqj4z 129 4 - - HYPH cord-254317-n2knqj4z 129 5 qPCR qPCR NNP cord-254317-n2knqj4z 129 6 targeting target VBG cord-254317-n2knqj4z 129 7 the the DT cord-254317-n2knqj4z 129 8 S S NNP cord-254317-n2knqj4z 129 9 gene gene NN cord-254317-n2knqj4z 129 10 of of IN cord-254317-n2knqj4z 129 11 each each DT cord-254317-n2knqj4z 129 12 virus virus NN cord-254317-n2knqj4z 129 13 . . . cord-254317-n2knqj4z 130 1 Fecal fecal JJ cord-254317-n2knqj4z 130 2 infectious infectious JJ cord-254317-n2knqj4z 130 3 PEDV PEDV NNP cord-254317-n2knqj4z 130 4 shedding shed VBG cord-254317-n2knqj4z 130 5 titers titer NNS cord-254317-n2knqj4z 130 6 were be VBD cord-254317-n2knqj4z 130 7 tested test VBN cord-254317-n2knqj4z 130 8 using use VBG cord-254317-n2knqj4z 130 9 Vero Vero NNP cord-254317-n2knqj4z 130 10 cells cell NNS cord-254317-n2knqj4z 130 11 in in IN cord-254317-n2knqj4z 130 12 96-well 96-well CD cord-254317-n2knqj4z 130 13 plates plate NNS cord-254317-n2knqj4z 130 14 and and CC cord-254317-n2knqj4z 130 15 determined determine VBD cord-254317-n2knqj4z 130 16 as as IN cord-254317-n2knqj4z 130 17 50 50 CD cord-254317-n2knqj4z 130 18 % % NN cord-254317-n2knqj4z 130 19 tissue tissue NN cord-254317-n2knqj4z 130 20 culture culture NN cord-254317-n2knqj4z 130 21 infective infective JJ cord-254317-n2knqj4z 130 22 doses dose NNS cord-254317-n2knqj4z 130 23 ( ( -LRB- cord-254317-n2knqj4z 130 24 TCID TCID NNP cord-254317-n2knqj4z 130 25 50 50 CD cord-254317-n2knqj4z 130 26 ) ) -RRB- cord-254317-n2knqj4z 131 1 ( ( -LRB- cord-254317-n2knqj4z 131 2 Reed Reed NNP cord-254317-n2knqj4z 131 3 and and CC cord-254317-n2knqj4z 131 4 Muench Muench NNP cord-254317-n2knqj4z 131 5 , , , cord-254317-n2knqj4z 131 6 1938 1938 CD cord-254317-n2knqj4z 131 7 ) ) -RRB- cord-254317-n2knqj4z 131 8 . . . cord-254317-n2knqj4z 132 1 At at IN cord-254317-n2knqj4z 132 2 necropsy necropsy JJ cord-254317-n2knqj4z 132 3 , , , cord-254317-n2knqj4z 132 4 three three CD cord-254317-n2knqj4z 132 5 sections section NNS cord-254317-n2knqj4z 132 6 of of IN cord-254317-n2knqj4z 132 7 the the DT cord-254317-n2knqj4z 132 8 jejunum jejunum NNS cord-254317-n2knqj4z 132 9 ( ( -LRB- cord-254317-n2knqj4z 132 10 proximal proximal JJ cord-254317-n2knqj4z 132 11 , , , cord-254317-n2knqj4z 132 12 middle middle JJ cord-254317-n2knqj4z 132 13 , , , cord-254317-n2knqj4z 132 14 and and CC cord-254317-n2knqj4z 132 15 distal distal JJ cord-254317-n2knqj4z 132 16 ) ) -RRB- cord-254317-n2knqj4z 132 17 and and CC cord-254317-n2knqj4z 132 18 one one CD cord-254317-n2knqj4z 132 19 section section NN cord-254317-n2knqj4z 132 20 of of IN cord-254317-n2knqj4z 132 21 the the DT cord-254317-n2knqj4z 132 22 ileum ileum NN cord-254317-n2knqj4z 132 23 were be VBD cord-254317-n2knqj4z 132 24 collected collect VBN cord-254317-n2knqj4z 132 25 and and CC cord-254317-n2knqj4z 132 26 fixed fix VBN cord-254317-n2knqj4z 132 27 in in IN cord-254317-n2knqj4z 132 28 3.7 3.7 CD cord-254317-n2knqj4z 132 29 % % NN cord-254317-n2knqj4z 132 30 formalin formalin NN cord-254317-n2knqj4z 132 31 ( ( -LRB- cord-254317-n2knqj4z 132 32 Fisher Fisher NNP cord-254317-n2knqj4z 132 33 scientific scientific JJ cord-254317-n2knqj4z 132 34 co co NNP cord-254317-n2knqj4z 132 35 LLC LLC NNP cord-254317-n2knqj4z 132 36 , , , cord-254317-n2knqj4z 132 37 Florence Florence NNP cord-254317-n2knqj4z 132 38 , , , cord-254317-n2knqj4z 132 39 KY KY NNP cord-254317-n2knqj4z 132 40 , , , cord-254317-n2knqj4z 132 41 USA USA NNP cord-254317-n2knqj4z 132 42 ) ) -RRB- cord-254317-n2knqj4z 132 43 . . . cord-254317-n2knqj4z 133 1 All all DT cord-254317-n2knqj4z 133 2 tissues tissue NNS cord-254317-n2knqj4z 133 3 were be VBD cord-254317-n2knqj4z 133 4 trimmed trim VBN cord-254317-n2knqj4z 133 5 , , , cord-254317-n2knqj4z 133 6 processed process VBN cord-254317-n2knqj4z 133 7 , , , cord-254317-n2knqj4z 133 8 embedded embed VBN cord-254317-n2knqj4z 133 9 in in IN cord-254317-n2knqj4z 133 10 paraffin paraffin NN cord-254317-n2knqj4z 133 11 , , , cord-254317-n2knqj4z 133 12 and and CC cord-254317-n2knqj4z 133 13 sectioned section VBN cord-254317-n2knqj4z 133 14 using use VBG cord-254317-n2knqj4z 133 15 routine routine JJ cord-254317-n2knqj4z 133 16 procedures procedure NNS cord-254317-n2knqj4z 133 17 . . . cord-254317-n2knqj4z 134 1 To to TO cord-254317-n2knqj4z 134 2 compare compare VB cord-254317-n2knqj4z 134 3 the the DT cord-254317-n2knqj4z 134 4 PEDV PEDV NNP cord-254317-n2knqj4z 134 5 - - HYPH cord-254317-n2knqj4z 134 6 specific specific JJ cord-254317-n2knqj4z 134 7 histopathological histopathological JJ cord-254317-n2knqj4z 134 8 changes change NNS cord-254317-n2knqj4z 134 9 among among IN cord-254317-n2knqj4z 134 10 different different JJ cord-254317-n2knqj4z 134 11 groups group NNS cord-254317-n2knqj4z 134 12 of of IN cord-254317-n2knqj4z 134 13 pigs pig NNS cord-254317-n2knqj4z 134 14 , , , cord-254317-n2knqj4z 134 15 IHC IHC NNP cord-254317-n2knqj4z 134 16 staining staining NN cord-254317-n2knqj4z 134 17 was be VBD cord-254317-n2knqj4z 134 18 performed perform VBN cord-254317-n2knqj4z 134 19 as as IN cord-254317-n2knqj4z 134 20 described describe VBN cord-254317-n2knqj4z 134 21 previously previously RB cord-254317-n2knqj4z 134 22 for for IN cord-254317-n2knqj4z 134 23 the the DT cord-254317-n2knqj4z 134 24 detection detection NN cord-254317-n2knqj4z 134 25 of of IN cord-254317-n2knqj4z 134 26 PEDV PEDV NNP cord-254317-n2knqj4z 134 27 N n CD cord-254317-n2knqj4z 134 28 proteins protein NNS cord-254317-n2knqj4z 134 29 using use VBG cord-254317-n2knqj4z 134 30 MAb MAb JJR cord-254317-n2knqj4z 134 31 SD6 SD6 NNP cord-254317-n2knqj4z 134 32 - - HYPH cord-254317-n2knqj4z 134 33 29 29 CD cord-254317-n2knqj4z 134 34 as as IN cord-254317-n2knqj4z 134 35 the the DT cord-254317-n2knqj4z 134 36 primary primary JJ cord-254317-n2knqj4z 134 37 antibody antibody NN cord-254317-n2knqj4z 134 38 ( ( -LRB- cord-254317-n2knqj4z 134 39 Hou Hou NNP cord-254317-n2knqj4z 134 40 et et FW cord-254317-n2knqj4z 134 41 al al NNP cord-254317-n2knqj4z 134 42 . . NNP cord-254317-n2knqj4z 134 43 , , , cord-254317-n2knqj4z 134 44 2017 2017 CD cord-254317-n2knqj4z 134 45 ) ) -RRB- cord-254317-n2knqj4z 134 46 . . . cord-254317-n2knqj4z 135 1 The the DT cord-254317-n2knqj4z 135 2 IHC IHC NNP cord-254317-n2knqj4z 135 3 staining staining NN cord-254317-n2knqj4z 135 4 was be VBD cord-254317-n2knqj4z 135 5 carried carry VBN cord-254317-n2knqj4z 135 6 out out RP cord-254317-n2knqj4z 135 7 using use VBG cord-254317-n2knqj4z 135 8 a a DT cord-254317-n2knqj4z 135 9 nonbiotin nonbiotin NN cord-254317-n2knqj4z 135 10 polymerized polymerize VBN cord-254317-n2knqj4z 135 11 horseradish horseradish NN cord-254317-n2knqj4z 135 12 peroxidase peroxidase NN cord-254317-n2knqj4z 135 13 system system NN cord-254317-n2knqj4z 135 14 ( ( -LRB- cord-254317-n2knqj4z 135 15 BioGenex BioGenex NNP cord-254317-n2knqj4z 135 16 Laboratories Laboratories NNPS cord-254317-n2knqj4z 135 17 , , , cord-254317-n2knqj4z 135 18 San San NNP cord-254317-n2knqj4z 135 19 Ramon Ramon NNP cord-254317-n2knqj4z 135 20 , , , cord-254317-n2knqj4z 135 21 CA CA NNP cord-254317-n2knqj4z 135 22 , , , cord-254317-n2knqj4z 135 23 USA USA NNP cord-254317-n2knqj4z 135 24 ) ) -RRB- cord-254317-n2knqj4z 135 25 . . . cord-254317-n2knqj4z 136 1 Finally finally RB cord-254317-n2knqj4z 136 2 , , , cord-254317-n2knqj4z 136 3 tissues tissue NNS cord-254317-n2knqj4z 136 4 were be VBD cord-254317-n2knqj4z 136 5 counterstained counterstaine VBN cord-254317-n2knqj4z 136 6 with with IN cord-254317-n2knqj4z 136 7 hematoxylin hematoxylin NNP cord-254317-n2knqj4z 136 8 . . . cord-254317-n2knqj4z 137 1 Images image NNS cord-254317-n2knqj4z 137 2 of of IN cord-254317-n2knqj4z 137 3 tissues tissue NNS cord-254317-n2knqj4z 137 4 were be VBD cord-254317-n2knqj4z 137 5 observed observe VBN cord-254317-n2knqj4z 137 6 and and CC cord-254317-n2knqj4z 137 7 captured capture VBN cord-254317-n2knqj4z 137 8 by by IN cord-254317-n2knqj4z 137 9 Olympus Olympus NNP cord-254317-n2knqj4z 137 10 IX-70 IX-70 NNP cord-254317-n2knqj4z 137 11 fluorescent fluorescent NN cord-254317-n2knqj4z 137 12 microscope microscope NN cord-254317-n2knqj4z 137 13 ( ( -LRB- cord-254317-n2knqj4z 137 14 Center Center NNP cord-254317-n2knqj4z 137 15 Valley Valley NNP cord-254317-n2knqj4z 137 16 , , , cord-254317-n2knqj4z 137 17 PA PA NNP cord-254317-n2knqj4z 137 18 , , , cord-254317-n2knqj4z 137 19 USA USA NNP cord-254317-n2knqj4z 137 20 ) ) -RRB- cord-254317-n2knqj4z 137 21 . . . cord-254317-n2knqj4z 138 1 Ratios ratio NNS cord-254317-n2knqj4z 138 2 of of IN cord-254317-n2knqj4z 138 3 villous villous NNP cord-254317-n2knqj4z 138 4 height height NN cord-254317-n2knqj4z 138 5 to to IN cord-254317-n2knqj4z 138 6 crypt crypt NN cord-254317-n2knqj4z 138 7 depth depth NN cord-254317-n2knqj4z 138 8 ( ( -LRB- cord-254317-n2knqj4z 138 9 VH/ vh/ DT cord-254317-n2knqj4z 138 10 CD CD NNP cord-254317-n2knqj4z 138 11 ) ) -RRB- cord-254317-n2knqj4z 138 12 of of IN cord-254317-n2knqj4z 138 13 the the DT cord-254317-n2knqj4z 138 14 jejunum jejunum NNS cord-254317-n2knqj4z 138 15 and and CC cord-254317-n2knqj4z 138 16 ileum ileum NN cord-254317-n2knqj4z 138 17 of of IN cord-254317-n2knqj4z 138 18 individual individual JJ cord-254317-n2knqj4z 138 19 piglets piglet NNS cord-254317-n2knqj4z 138 20 were be VBD cord-254317-n2knqj4z 138 21 measured measure VBN cord-254317-n2knqj4z 138 22 using use VBG cord-254317-n2knqj4z 138 23 a a DT cord-254317-n2knqj4z 138 24 computerized computerized JJ cord-254317-n2knqj4z 138 25 imaging imaging NN cord-254317-n2knqj4z 138 26 system system NN cord-254317-n2knqj4z 138 27 ( ( -LRB- cord-254317-n2knqj4z 138 28 MetaMorph MetaMorph NNP cord-254317-n2knqj4z 138 29 , , , cord-254317-n2knqj4z 138 30 Olympus Olympus NNP cord-254317-n2knqj4z 138 31 , , , cord-254317-n2knqj4z 138 32 Japan Japan NNP cord-254317-n2knqj4z 138 33 ) ) -RRB- cord-254317-n2knqj4z 138 34 as as IN cord-254317-n2knqj4z 138 35 described describe VBN cord-254317-n2knqj4z 138 36 previously previously RB cord-254317-n2knqj4z 138 37 . . . cord-254317-n2knqj4z 139 1 For for IN cord-254317-n2knqj4z 139 2 each each DT cord-254317-n2knqj4z 139 3 intestinal intestinal JJ cord-254317-n2knqj4z 139 4 section section NN cord-254317-n2knqj4z 139 5 , , , cord-254317-n2knqj4z 139 6 10 10 CD cord-254317-n2knqj4z 139 7 villi villus NNS cord-254317-n2knqj4z 139 8 and and CC cord-254317-n2knqj4z 139 9 crypts crypt NNS cord-254317-n2knqj4z 139 10 were be VBD cord-254317-n2knqj4z 139 11 measured measure VBN cord-254317-n2knqj4z 139 12 . . . cord-254317-n2knqj4z 140 1 To to TO cord-254317-n2knqj4z 140 2 detect detect VB cord-254317-n2knqj4z 140 3 and and CC cord-254317-n2knqj4z 140 4 differentiate differentiate VB cord-254317-n2knqj4z 140 5 icPC22 icpc22 CD cord-254317-n2knqj4z 141 1 A a LS cord-254317-n2knqj4z 141 2 - - : cord-254317-n2knqj4z 141 3 and and CC cord-254317-n2knqj4z 141 4 icPC22 icPC22 NNP cord-254317-n2knqj4z 141 5 A A NNP cord-254317-n2knqj4z 141 6 - - HYPH cord-254317-n2knqj4z 141 7 S1Δ197-infected s1δ197-infected JJ cord-254317-n2knqj4z 141 8 cells cell NNS cord-254317-n2knqj4z 141 9 in in IN cord-254317-n2knqj4z 141 10 the the DT cord-254317-n2knqj4z 141 11 coinfected coinfected JJ cord-254317-n2knqj4z 141 12 pigs pig NNS cord-254317-n2knqj4z 141 13 , , , cord-254317-n2knqj4z 141 14 IF if IN cord-254317-n2knqj4z 141 15 staining staining NN cord-254317-n2knqj4z 141 16 was be VBD cord-254317-n2knqj4z 141 17 performed perform VBN cord-254317-n2knqj4z 141 18 . . . cord-254317-n2knqj4z 142 1 The the DT cord-254317-n2knqj4z 142 2 slide slide NN cord-254317-n2knqj4z 142 3 preparation preparation NN cord-254317-n2knqj4z 142 4 steps step NNS cord-254317-n2knqj4z 142 5 were be VBD cord-254317-n2knqj4z 142 6 as as RB cord-254317-n2knqj4z 142 7 same same JJ cord-254317-n2knqj4z 142 8 as as IN cord-254317-n2knqj4z 142 9 those those DT cord-254317-n2knqj4z 142 10 of of IN cord-254317-n2knqj4z 142 11 the the DT cord-254317-n2knqj4z 142 12 above above JJ cord-254317-n2knqj4z 142 13 IHC IHC NNP cord-254317-n2knqj4z 142 14 procedure procedure NN cord-254317-n2knqj4z 142 15 . . . cord-254317-n2knqj4z 143 1 The the DT cord-254317-n2knqj4z 143 2 mixture mixture NN cord-254317-n2knqj4z 143 3 of of IN cord-254317-n2knqj4z 143 4 mouse mouse NN cord-254317-n2knqj4z 143 5 MAbs MAbs NNP cord-254317-n2knqj4z 143 6 56H4 56h4 CD cord-254317-n2knqj4z 143 7 , , , cord-254317-n2knqj4z 143 8 60F11 60f11 CD cord-254317-n2knqj4z 143 9 and and CC cord-254317-n2knqj4z 143 10 72A8 72a8 CD cord-254317-n2knqj4z 143 11 ( ( -LRB- cord-254317-n2knqj4z 143 12 1 1 CD cord-254317-n2knqj4z 143 13 : : SYM cord-254317-n2knqj4z 143 14 100 100 CD cord-254317-n2knqj4z 143 15 in in IN cord-254317-n2knqj4z 143 16 PBS PBS NNP cord-254317-n2knqj4z 143 17 ) ) -RRB- cord-254317-n2knqj4z 143 18 ( ( -LRB- cord-254317-n2knqj4z 143 19 Li Li NNP cord-254317-n2knqj4z 143 20 et et NNP cord-254317-n2knqj4z 143 21 al al NNP cord-254317-n2knqj4z 143 22 . . NNP cord-254317-n2knqj4z 143 23 , , , cord-254317-n2knqj4z 143 24 2017a 2017a CD cord-254317-n2knqj4z 143 25 ) ) -RRB- cord-254317-n2knqj4z 143 26 targeting target VBG cord-254317-n2knqj4z 143 27 the the DT cord-254317-n2knqj4z 143 28 S1 s1 NN cord-254317-n2knqj4z 143 29 ° ° NN cord-254317-n2knqj4z 143 30 domain domain NN cord-254317-n2knqj4z 143 31 of of IN cord-254317-n2knqj4z 143 32 PEDV PEDV NNP cord-254317-n2knqj4z 143 33 S S NNP cord-254317-n2knqj4z 143 34 protein protein NN cord-254317-n2knqj4z 143 35 was be VBD cord-254317-n2knqj4z 143 36 used use VBN cord-254317-n2knqj4z 143 37 as as IN cord-254317-n2knqj4z 143 38 the the DT cord-254317-n2knqj4z 143 39 primary primary JJ cord-254317-n2knqj4z 143 40 antibody antibody NN cord-254317-n2knqj4z 143 41 for for IN cord-254317-n2knqj4z 143 42 the the DT cord-254317-n2knqj4z 143 43 staining staining NN cord-254317-n2knqj4z 143 44 of of IN cord-254317-n2knqj4z 143 45 icPC22 icPC22 NNP cord-254317-n2knqj4z 143 46 A a RB cord-254317-n2knqj4z 143 47 - - HYPH cord-254317-n2knqj4z 143 48 infected infect VBN cord-254317-n2knqj4z 143 49 cells cell NNS cord-254317-n2knqj4z 143 50 only only RB cord-254317-n2knqj4z 143 51 . . . cord-254317-n2knqj4z 144 1 Tissues tissue NNS cord-254317-n2knqj4z 144 2 were be VBD cord-254317-n2knqj4z 144 3 incubated incubate VBN cord-254317-n2knqj4z 144 4 at at IN cord-254317-n2knqj4z 144 5 4 4 CD cord-254317-n2knqj4z 144 6 ℃ ℃ NNS cord-254317-n2knqj4z 144 7 overnight overnight RB cord-254317-n2knqj4z 144 8 , , , cord-254317-n2knqj4z 144 9 after after IN cord-254317-n2knqj4z 144 10 three three CD cord-254317-n2knqj4z 144 11 washings washing NNS cord-254317-n2knqj4z 144 12 with with IN cord-254317-n2knqj4z 144 13 PBST PBST NNP cord-254317-n2knqj4z 144 14 ( ( -LRB- cord-254317-n2knqj4z 144 15 PBS PBS NNP cord-254317-n2knqj4z 144 16 with with IN cord-254317-n2knqj4z 144 17 0.1 0.1 CD cord-254317-n2knqj4z 144 18 % % NN cord-254317-n2knqj4z 144 19 tween20 tween20 NN cord-254317-n2knqj4z 144 20 ) ) -RRB- cord-254317-n2knqj4z 144 21 , , , cord-254317-n2knqj4z 144 22 Alexa Alexa NNP cord-254317-n2knqj4z 144 23 Fluor Fluor NNP cord-254317-n2knqj4z 145 1 594-conjugated 594-conjugated CD cord-254317-n2knqj4z 145 2 goat goat NNP cord-254317-n2knqj4z 145 3 antimouse antimouse NNP cord-254317-n2knqj4z 145 4 IgG IgG NNP cord-254317-n2knqj4z 145 5 ( ( -LRB- cord-254317-n2knqj4z 145 6 H H NNP cord-254317-n2knqj4z 145 7 + + CC cord-254317-n2knqj4z 145 8 L l NN cord-254317-n2knqj4z 145 9 ) ) -RRB- cord-254317-n2knqj4z 146 1 ( ( -LRB- cord-254317-n2knqj4z 146 2 Thermo Thermo NNP cord-254317-n2knqj4z 146 3 Fisher Fisher NNP cord-254317-n2knqj4z 146 4 Scientific Scientific NNP cord-254317-n2knqj4z 146 5 ) ) -RRB- cord-254317-n2knqj4z 146 6 ( ( -LRB- cord-254317-n2knqj4z 146 7 1 1 CD cord-254317-n2knqj4z 146 8 : : : cord-254317-n2knqj4z 146 9 500 500 CD cord-254317-n2knqj4z 146 10 diluted dilute VBN cord-254317-n2knqj4z 146 11 in in IN cord-254317-n2knqj4z 146 12 PBS PBS NNP cord-254317-n2knqj4z 146 13 ) ) -RRB- cord-254317-n2knqj4z 146 14 was be VBD cord-254317-n2knqj4z 146 15 used use VBN cord-254317-n2knqj4z 146 16 as as IN cord-254317-n2knqj4z 146 17 the the DT cord-254317-n2knqj4z 146 18 second second JJ cord-254317-n2knqj4z 146 19 antibody antibody NN cord-254317-n2knqj4z 146 20 and and CC cord-254317-n2knqj4z 146 21 tissues tissue NNS cord-254317-n2knqj4z 146 22 were be VBD cord-254317-n2knqj4z 146 23 incubated incubate VBN cord-254317-n2knqj4z 146 24 at at IN cord-254317-n2knqj4z 146 25 room room NN cord-254317-n2knqj4z 146 26 temperature temperature NN cord-254317-n2knqj4z 146 27 for for IN cord-254317-n2knqj4z 146 28 2 2 CD cord-254317-n2knqj4z 146 29 h. h. NN cord-254317-n2knqj4z 146 30 After after IN cord-254317-n2knqj4z 146 31 washing wash VBG cord-254317-n2knqj4z 146 32 with with IN cord-254317-n2knqj4z 146 33 PBST PBST NNP cord-254317-n2knqj4z 146 34 , , , cord-254317-n2knqj4z 146 35 guinea guinea NN cord-254317-n2knqj4z 146 36 pig pig NN cord-254317-n2knqj4z 146 37 PAb PAb NNS cord-254317-n2knqj4z 146 38 GP17 GP17 NNP cord-254317-n2knqj4z 146 39 ( ( -LRB- cord-254317-n2knqj4z 146 40 1 1 CD cord-254317-n2knqj4z 146 41 : : : cord-254317-n2knqj4z 146 42 200 200 CD cord-254317-n2knqj4z 146 43 diluted dilute VBN cord-254317-n2knqj4z 146 44 in in IN cord-254317-n2knqj4z 146 45 PBS PBS NNP cord-254317-n2knqj4z 146 46 ) ) -RRB- cord-254317-n2knqj4z 146 47 , , , cord-254317-n2knqj4z 146 48 targeting target VBG cord-254317-n2knqj4z 146 49 the the DT cord-254317-n2knqj4z 146 50 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 146 51 and and CC cord-254317-n2knqj4z 146 52 was be VBD cord-254317-n2knqj4z 146 53 for for IN cord-254317-n2knqj4z 146 54 the the DT cord-254317-n2knqj4z 146 55 staining staining NN cord-254317-n2knqj4z 146 56 of of IN cord-254317-n2knqj4z 146 57 both both DT cord-254317-n2knqj4z 146 58 viruses virus NNS cord-254317-n2knqj4z 146 59 , , , cord-254317-n2knqj4z 146 60 was be VBD cord-254317-n2knqj4z 146 61 added add VBN cord-254317-n2knqj4z 146 62 . . . cord-254317-n2knqj4z 147 1 Then then RB cord-254317-n2knqj4z 147 2 , , , cord-254317-n2knqj4z 147 3 the the DT cord-254317-n2knqj4z 147 4 slides slide NNS cord-254317-n2knqj4z 147 5 were be VBD cord-254317-n2knqj4z 147 6 incubated incubate VBN cord-254317-n2knqj4z 147 7 at at IN cord-254317-n2knqj4z 147 8 room room NN cord-254317-n2knqj4z 147 9 temperature temperature NN cord-254317-n2knqj4z 147 10 for for IN cord-254317-n2knqj4z 147 11 2 2 CD cord-254317-n2knqj4z 147 12 h. h. NN cord-254317-n2knqj4z 148 1 After after IN cord-254317-n2knqj4z 148 2 washing wash VBG cord-254317-n2knqj4z 148 3 three three CD cord-254317-n2knqj4z 148 4 times time NNS cord-254317-n2knqj4z 148 5 with with IN cord-254317-n2knqj4z 148 6 PBST PBST NNP cord-254317-n2knqj4z 148 7 , , , cord-254317-n2knqj4z 148 8 Alexa Alexa NNP cord-254317-n2knqj4z 148 9 Fluor Fluor NNP cord-254317-n2knqj4z 148 10 488-conjugated 488-conjugated CD cord-254317-n2knqj4z 148 11 goat goat NNP cord-254317-n2knqj4z 148 12 anti anti JJ cord-254317-n2knqj4z 148 13 - - JJ cord-254317-n2knqj4z 148 14 guinea guinea JJ cord-254317-n2knqj4z 148 15 pig pig NN cord-254317-n2knqj4z 148 16 IgG IgG NNP cord-254317-n2knqj4z 148 17 ( ( -LRB- cord-254317-n2knqj4z 148 18 H H NNP cord-254317-n2knqj4z 148 19 + + CC cord-254317-n2knqj4z 148 20 L l NN cord-254317-n2knqj4z 148 21 ) ) -RRB- cord-254317-n2knqj4z 149 1 ( ( -LRB- cord-254317-n2knqj4z 149 2 Thermo Thermo NNP cord-254317-n2knqj4z 149 3 Fisher Fisher NNP cord-254317-n2knqj4z 149 4 Scientific Scientific NNP cord-254317-n2knqj4z 149 5 ) ) -RRB- cord-254317-n2knqj4z 149 6 ( ( -LRB- cord-254317-n2knqj4z 149 7 1 1 CD cord-254317-n2knqj4z 149 8 : : : cord-254317-n2knqj4z 149 9 500 500 CD cord-254317-n2knqj4z 149 10 diluted dilute VBN cord-254317-n2knqj4z 149 11 in in IN cord-254317-n2knqj4z 149 12 PBS PBS NNP cord-254317-n2knqj4z 149 13 ) ) -RRB- cord-254317-n2knqj4z 149 14 was be VBD cord-254317-n2knqj4z 149 15 used use VBN cord-254317-n2knqj4z 149 16 as as IN cord-254317-n2knqj4z 149 17 the the DT cord-254317-n2knqj4z 149 18 2nd 2nd JJ cord-254317-n2knqj4z 149 19 antibody antibody NN cord-254317-n2knqj4z 149 20 and and CC cord-254317-n2knqj4z 149 21 the the DT cord-254317-n2knqj4z 149 22 slides slide NNS cord-254317-n2knqj4z 149 23 were be VBD cord-254317-n2knqj4z 149 24 incubated incubate VBN cord-254317-n2knqj4z 149 25 at at IN cord-254317-n2knqj4z 149 26 room room NN cord-254317-n2knqj4z 149 27 temperature temperature NN cord-254317-n2knqj4z 149 28 for for IN cord-254317-n2knqj4z 149 29 2 2 CD cord-254317-n2knqj4z 149 30 h. h. NN cord-254317-n2knqj4z 149 31 After after IN cord-254317-n2knqj4z 149 32 washing wash VBG cord-254317-n2knqj4z 149 33 with with IN cord-254317-n2knqj4z 149 34 PBST PBST NNP cord-254317-n2knqj4z 149 35 , , , cord-254317-n2knqj4z 149 36 1 1 CD cord-254317-n2knqj4z 149 37 mg mg NNP cord-254317-n2knqj4z 149 38 / / SYM cord-254317-n2knqj4z 149 39 mL ml NN cord-254317-n2knqj4z 149 40 DAPI DAPI NNP cord-254317-n2knqj4z 149 41 ( ( -LRB- cord-254317-n2knqj4z 149 42 4′,6-Diamidino-2-Phenylindole 4′,6-diamidino-2-phenylindole CD cord-254317-n2knqj4z 149 43 , , , cord-254317-n2knqj4z 149 44 Dihydrochloride Dihydrochloride NNP cord-254317-n2knqj4z 149 45 , , , cord-254317-n2knqj4z 149 46 Roche Roche NNP cord-254317-n2knqj4z 149 47 Life Life NNP cord-254317-n2knqj4z 149 48 Science Science NNP cord-254317-n2knqj4z 149 49 , , , cord-254317-n2knqj4z 149 50 Indianapolis Indianapolis NNP cord-254317-n2knqj4z 149 51 , , , cord-254317-n2knqj4z 149 52 IN IN NNP cord-254317-n2knqj4z 149 53 , , , cord-254317-n2knqj4z 149 54 USA USA NNP cord-254317-n2knqj4z 149 55 ) ) -RRB- cord-254317-n2knqj4z 149 56 was be VBD cord-254317-n2knqj4z 149 57 added add VBN cord-254317-n2knqj4z 149 58 for for IN cord-254317-n2knqj4z 149 59 nucleic nucleic JJ cord-254317-n2knqj4z 149 60 acid acid NN cord-254317-n2knqj4z 149 61 staining staining NN cord-254317-n2knqj4z 149 62 . . . cord-254317-n2knqj4z 150 1 Finally finally RB cord-254317-n2knqj4z 150 2 , , , cord-254317-n2knqj4z 150 3 an an DT cord-254317-n2knqj4z 150 4 autofluorescence autofluorescence NN cord-254317-n2knqj4z 150 5 quenching quenching NN cord-254317-n2knqj4z 150 6 kit kit NN cord-254317-n2knqj4z 150 7 ( ( -LRB- cord-254317-n2knqj4z 150 8 Vector vector NN cord-254317-n2knqj4z 150 9 ® ® . cord-254317-n2knqj4z 150 10 TrueVIEW TrueVIEW NNP cord-254317-n2knqj4z 150 11 ™ ™ NN cord-254317-n2knqj4z 150 12 , , , cord-254317-n2knqj4z 150 13 Burlingame Burlingame NNP cord-254317-n2knqj4z 150 14 , , , cord-254317-n2knqj4z 150 15 CA CA NNP cord-254317-n2knqj4z 150 16 , , , cord-254317-n2knqj4z 150 17 USA USA NNP cord-254317-n2knqj4z 150 18 ) ) -RRB- cord-254317-n2knqj4z 150 19 was be VBD cord-254317-n2knqj4z 150 20 used use VBN cord-254317-n2knqj4z 150 21 to to TO cord-254317-n2knqj4z 150 22 quench quench VB cord-254317-n2knqj4z 150 23 the the DT cord-254317-n2knqj4z 150 24 autofluorescence autofluorescence NNS cord-254317-n2knqj4z 150 25 of of IN cord-254317-n2knqj4z 150 26 the the DT cord-254317-n2knqj4z 150 27 tissues tissue NNS cord-254317-n2knqj4z 150 28 . . . cord-254317-n2knqj4z 151 1 Images image NNS cord-254317-n2knqj4z 151 2 of of IN cord-254317-n2knqj4z 151 3 stained stain VBN cord-254317-n2knqj4z 151 4 tissues tissue NNS cord-254317-n2knqj4z 151 5 were be VBD cord-254317-n2knqj4z 151 6 captured capture VBN cord-254317-n2knqj4z 151 7 by by IN cord-254317-n2knqj4z 151 8 Olympus Olympus NNP cord-254317-n2knqj4z 151 9 IX-70 IX-70 NNP cord-254317-n2knqj4z 151 10 fluorescent fluorescent JJ cord-254317-n2knqj4z 151 11 microscope microscope NN cord-254317-n2knqj4z 151 12 . . . cord-254317-n2knqj4z 152 1 Red red JJ cord-254317-n2knqj4z 152 2 , , , cord-254317-n2knqj4z 152 3 green green JJ cord-254317-n2knqj4z 152 4 and and CC cord-254317-n2knqj4z 152 5 blue blue JJ cord-254317-n2knqj4z 152 6 fluorescence fluorescence NN cord-254317-n2knqj4z 152 7 staining staining NN cord-254317-n2knqj4z 152 8 was be VBD cord-254317-n2knqj4z 152 9 merged merge VBN cord-254317-n2knqj4z 152 10 by by IN cord-254317-n2knqj4z 152 11 ImageJ imagej WDT cord-254317-n2knqj4z 152 12 software software NN cord-254317-n2knqj4z 152 13 ( ( -LRB- cord-254317-n2knqj4z 152 14 https://imagej.nih https://imagej.nih ADD cord-254317-n2knqj4z 152 15 . . . cord-254317-n2knqj4z 153 1 gov gov NNP cord-254317-n2knqj4z 153 2 ) ) -RRB- cord-254317-n2knqj4z 153 3 . . . cord-254317-n2knqj4z 154 1 2.5 2.5 CD cord-254317-n2knqj4z 154 2 . . . cord-254317-n2knqj4z 155 1 Isolation isolation NN cord-254317-n2knqj4z 155 2 of of IN cord-254317-n2knqj4z 155 3 the the DT cord-254317-n2knqj4z 155 4 pig pig NN cord-254317-n2knqj4z 155 5 - - HYPH cord-254317-n2knqj4z 155 6 passaged passage VBN cord-254317-n2knqj4z 155 7 icPC22 icpc22 NN cord-254317-n2knqj4z 156 1 A a NN cord-254317-n2knqj4z 156 2 and and CC cord-254317-n2knqj4z 156 3 icPC22 icpc22 NN cord-254317-n2knqj4z 157 1 A a LS cord-254317-n2knqj4z 157 2 - - HYPH cord-254317-n2knqj4z 157 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 157 4 from from IN cord-254317-n2knqj4z 157 5 the the DT cord-254317-n2knqj4z 157 6 SIC sic NN cord-254317-n2knqj4z 157 7 of of IN cord-254317-n2knqj4z 157 8 a a DT cord-254317-n2knqj4z 157 9 pig pig NN cord-254317-n2knqj4z 157 10 coinfected coinfecte VBN cord-254317-n2knqj4z 157 11 with with IN cord-254317-n2knqj4z 157 12 the the DT cord-254317-n2knqj4z 157 13 viruses virus NNS cord-254317-n2knqj4z 158 1 The the DT cord-254317-n2knqj4z 158 2 SIC sic NN cord-254317-n2knqj4z 158 3 ( ( -LRB- cord-254317-n2knqj4z 158 4 sample sample NN cord-254317-n2knqj4z 158 5 # # NN cord-254317-n2knqj4z 158 6 PE1158 pe1158 NN cord-254317-n2knqj4z 158 7 ) ) -RRB- cord-254317-n2knqj4z 158 8 of of IN cord-254317-n2knqj4z 158 9 a a DT cord-254317-n2knqj4z 158 10 coinfected coinfected JJ cord-254317-n2knqj4z 158 11 piglet piglet NN cord-254317-n2knqj4z 158 12 in in IN cord-254317-n2knqj4z 158 13 group group NN cord-254317-n2knqj4z 158 14 3 3 CD cord-254317-n2knqj4z 158 15 was be VBD cord-254317-n2knqj4z 158 16 positive positive JJ cord-254317-n2knqj4z 158 17 for for IN cord-254317-n2knqj4z 158 18 both both DT cord-254317-n2knqj4z 158 19 viruses virus NNS cord-254317-n2knqj4z 158 20 by by IN cord-254317-n2knqj4z 158 21 the the DT cord-254317-n2knqj4z 158 22 duplex duplex JJ cord-254317-n2knqj4z 158 23 RT rt NN cord-254317-n2knqj4z 158 24 - - HYPH cord-254317-n2knqj4z 158 25 qPCR qPCR NNP cord-254317-n2knqj4z 158 26 . . . cord-254317-n2knqj4z 159 1 Virus virus NN cord-254317-n2knqj4z 159 2 isolation isolation NN cord-254317-n2knqj4z 159 3 was be VBD cord-254317-n2knqj4z 159 4 performed perform VBN cord-254317-n2knqj4z 159 5 using use VBG cord-254317-n2knqj4z 159 6 plague plague NN cord-254317-n2knqj4z 159 7 assays assay NNS cord-254317-n2knqj4z 159 8 ( ( -LRB- cord-254317-n2knqj4z 159 9 Oka Oka NNP cord-254317-n2knqj4z 159 10 et et NNP cord-254317-n2knqj4z 159 11 al al NNP cord-254317-n2knqj4z 159 12 . . NNP cord-254317-n2knqj4z 159 13 , , , cord-254317-n2knqj4z 159 14 2014 2014 CD cord-254317-n2knqj4z 159 15 ) ) -RRB- cord-254317-n2knqj4z 159 16 . . . cord-254317-n2knqj4z 160 1 The the DT cord-254317-n2knqj4z 160 2 SIC sic NN cord-254317-n2knqj4z 160 3 was be VBD cord-254317-n2knqj4z 160 4 diluted dilute VBN cord-254317-n2knqj4z 160 5 in in IN cord-254317-n2knqj4z 160 6 DMEM DMEM NNP cord-254317-n2knqj4z 160 7 and and CC cord-254317-n2knqj4z 160 8 the the DT cord-254317-n2knqj4z 160 9 10 10 CD cord-254317-n2knqj4z 160 10 % % NN cord-254317-n2knqj4z 160 11 suspension suspension NN cord-254317-n2knqj4z 160 12 was be VBD cord-254317-n2knqj4z 160 13 vortexed vortexe VBN cord-254317-n2knqj4z 160 14 briefly briefly RB cord-254317-n2knqj4z 160 15 followed follow VBN cord-254317-n2knqj4z 160 16 by by IN cord-254317-n2knqj4z 160 17 centrifugation centrifugation NN cord-254317-n2knqj4z 160 18 at at IN cord-254317-n2knqj4z 160 19 15,000 15,000 CD cord-254317-n2knqj4z 160 20 ×g ×g NNS cord-254317-n2knqj4z 160 21 for for IN cord-254317-n2knqj4z 160 22 3 3 CD cord-254317-n2knqj4z 160 23 min min NN cord-254317-n2knqj4z 160 24 at at IN cord-254317-n2knqj4z 160 25 4 4 CD cord-254317-n2knqj4z 160 26 ℃ ℃ NNS cord-254317-n2knqj4z 160 27 . . . cord-254317-n2knqj4z 161 1 A a DT cord-254317-n2knqj4z 161 2 series series NN cord-254317-n2knqj4z 161 3 of of IN cord-254317-n2knqj4z 161 4 10-fold 10-fold JJ cord-254317-n2knqj4z 161 5 dilutions dilution NNS cord-254317-n2knqj4z 161 6 ( ( -LRB- cord-254317-n2knqj4z 161 7 10 10 CD cord-254317-n2knqj4z 161 8 −1 −1 NNP cord-254317-n2knqj4z 161 9 -10 -10 NNP cord-254317-n2knqj4z 161 10 −5 −5 NNP cord-254317-n2knqj4z 161 11 ) ) -RRB- cord-254317-n2knqj4z 161 12 of of IN cord-254317-n2knqj4z 161 13 the the DT cord-254317-n2knqj4z 161 14 supernatants supernatant NNS cord-254317-n2knqj4z 161 15 were be VBD cord-254317-n2knqj4z 161 16 prepared prepare VBN cord-254317-n2knqj4z 161 17 in in IN cord-254317-n2knqj4z 161 18 DMEM DMEM NNP cord-254317-n2knqj4z 161 19 ( ( -LRB- cord-254317-n2knqj4z 161 20 containing contain VBG cord-254317-n2knqj4z 161 21 7.5 7.5 CD cord-254317-n2knqj4z 161 22 μg μg NN cord-254317-n2knqj4z 161 23 / / SYM cord-254317-n2knqj4z 161 24 mL ml NN cord-254317-n2knqj4z 161 25 trypsin trypsin NN cord-254317-n2knqj4z 161 26 ) ) -RRB- cord-254317-n2knqj4z 161 27 and and CC cord-254317-n2knqj4z 161 28 were be VBD cord-254317-n2knqj4z 161 29 used use VBN cord-254317-n2knqj4z 161 30 immediately immediately RB cord-254317-n2knqj4z 161 31 for for IN cord-254317-n2knqj4z 161 32 inoculation inoculation NN cord-254317-n2knqj4z 161 33 of of IN cord-254317-n2knqj4z 161 34 Vero Vero NNP cord-254317-n2knqj4z 161 35 cell cell NN cord-254317-n2knqj4z 161 36 monolayers monolayer NNS cord-254317-n2knqj4z 161 37 in in IN cord-254317-n2knqj4z 161 38 6-well 6-well CD cord-254317-n2knqj4z 161 39 plates plate NNS cord-254317-n2knqj4z 161 40 ( ( -LRB- cord-254317-n2knqj4z 161 41 200 200 CD cord-254317-n2knqj4z 161 42 μL μL NFP cord-254317-n2knqj4z 161 43 per per FW cord-254317-n2knqj4z 161 44 well well RB cord-254317-n2knqj4z 161 45 ) ) -RRB- cord-254317-n2knqj4z 161 46 . . . cord-254317-n2knqj4z 162 1 After after IN cord-254317-n2knqj4z 162 2 incubating incubate VBG cord-254317-n2knqj4z 162 3 at at IN cord-254317-n2knqj4z 162 4 37 37 CD cord-254317-n2knqj4z 162 5 ℃ ℃ NNS cord-254317-n2knqj4z 162 6 for for IN cord-254317-n2knqj4z 162 7 1 1 CD cord-254317-n2knqj4z 162 8 h h NN cord-254317-n2knqj4z 162 9 , , , cord-254317-n2knqj4z 162 10 the the DT cord-254317-n2knqj4z 162 11 inoculum inoculum NN cord-254317-n2knqj4z 162 12 was be VBD cord-254317-n2knqj4z 162 13 removed remove VBN cord-254317-n2knqj4z 162 14 and and CC cord-254317-n2knqj4z 162 15 the the DT cord-254317-n2knqj4z 162 16 monolayers monolayer NNS cord-254317-n2knqj4z 162 17 were be VBD cord-254317-n2knqj4z 162 18 washed wash VBN cord-254317-n2knqj4z 162 19 once once RB cord-254317-n2knqj4z 162 20 with with IN cord-254317-n2knqj4z 162 21 PBS PBS NNP cord-254317-n2knqj4z 162 22 . . . cord-254317-n2knqj4z 163 1 Then then RB cord-254317-n2knqj4z 163 2 2 2 CD cord-254317-n2knqj4z 163 3 mL ml NN cord-254317-n2knqj4z 163 4 / / SYM cord-254317-n2knqj4z 163 5 well well RB cord-254317-n2knqj4z 163 6 of of IN cord-254317-n2knqj4z 163 7 agarose agarose JJ cord-254317-n2knqj4z 163 8 overlay overlay NN cord-254317-n2knqj4z 163 9 was be VBD cord-254317-n2knqj4z 163 10 added add VBN cord-254317-n2knqj4z 163 11 . . . cord-254317-n2knqj4z 164 1 The the DT cord-254317-n2knqj4z 164 2 plate plate NN cord-254317-n2knqj4z 164 3 was be VBD cord-254317-n2knqj4z 164 4 kept keep VBN cord-254317-n2knqj4z 164 5 for for IN cord-254317-n2knqj4z 164 6 3 3 CD cord-254317-n2knqj4z 164 7 days day NNS cord-254317-n2knqj4z 164 8 before before IN cord-254317-n2knqj4z 164 9 picking pick VBG cord-254317-n2knqj4z 164 10 up up RP cord-254317-n2knqj4z 164 11 clones clone NNS cord-254317-n2knqj4z 164 12 . . . cord-254317-n2knqj4z 165 1 For for IN cord-254317-n2knqj4z 165 2 propagating propagate VBG cord-254317-n2knqj4z 165 3 each each DT cord-254317-n2knqj4z 165 4 clone clone NN cord-254317-n2knqj4z 165 5 , , , cord-254317-n2knqj4z 165 6 Vero Vero NNP cord-254317-n2knqj4z 165 7 cell cell NN cord-254317-n2knqj4z 165 8 monolayers monolayer NNS cord-254317-n2knqj4z 165 9 in in IN cord-254317-n2knqj4z 165 10 96-well 96-well CD cord-254317-n2knqj4z 165 11 plates plate NNS cord-254317-n2knqj4z 165 12 were be VBD cord-254317-n2knqj4z 165 13 prepared prepared JJ cord-254317-n2knqj4z 165 14 and and CC cord-254317-n2knqj4z 165 15 individual individual JJ cord-254317-n2knqj4z 165 16 plagues plague NNS cord-254317-n2knqj4z 165 17 were be VBD cord-254317-n2knqj4z 165 18 picked pick VBN cord-254317-n2knqj4z 165 19 and and CC cord-254317-n2knqj4z 165 20 added add VBN cord-254317-n2knqj4z 165 21 into into IN cord-254317-n2knqj4z 165 22 individual individual JJ cord-254317-n2knqj4z 165 23 wells well NNS cord-254317-n2knqj4z 165 24 . . . cord-254317-n2knqj4z 166 1 At at IN cord-254317-n2knqj4z 166 2 3 3 CD cord-254317-n2knqj4z 166 3 dpi dpi NN cord-254317-n2knqj4z 166 4 , , , cord-254317-n2knqj4z 166 5 RNA RNA NNP cord-254317-n2knqj4z 166 6 was be VBD cord-254317-n2knqj4z 166 7 extracted extract VBN cord-254317-n2knqj4z 166 8 and and CC cord-254317-n2knqj4z 166 9 the the DT cord-254317-n2knqj4z 166 10 duplex duplex JJ cord-254317-n2knqj4z 166 11 RT rt NN cord-254317-n2knqj4z 166 12 - - HYPH cord-254317-n2knqj4z 166 13 qPCR qpcr NN cord-254317-n2knqj4z 166 14 method method NN cord-254317-n2knqj4z 166 15 specific specific JJ cord-254317-n2knqj4z 166 16 for for IN cord-254317-n2knqj4z 166 17 both both DT cord-254317-n2knqj4z 166 18 viruses virus NNS cord-254317-n2knqj4z 166 19 was be VBD cord-254317-n2knqj4z 166 20 performed perform VBN cord-254317-n2knqj4z 166 21 . . . cord-254317-n2knqj4z 167 1 2.6 2.6 CD cord-254317-n2knqj4z 167 2 . . . cord-254317-n2knqj4z 168 1 Multi multi JJ cord-254317-n2knqj4z 168 2 - - JJ cord-254317-n2knqj4z 168 3 step step JJ cord-254317-n2knqj4z 168 4 growth growth NN cord-254317-n2knqj4z 168 5 kinetics kinetic NNS cord-254317-n2knqj4z 168 6 and and CC cord-254317-n2knqj4z 168 7 IF if IN cord-254317-n2knqj4z 168 8 staining staining NN cord-254317-n2knqj4z 168 9 of of IN cord-254317-n2knqj4z 168 10 coinfection coinfection NN cord-254317-n2knqj4z 168 11 of of IN cord-254317-n2knqj4z 168 12 PEDV PEDV NNP cord-254317-n2knqj4z 168 13 icPC22A icPC22A NNP cord-254317-n2knqj4z 168 14 and and CC cord-254317-n2knqj4z 168 15 icPC22A icPC22A NNP cord-254317-n2knqj4z 168 16 - - HYPH cord-254317-n2knqj4z 168 17 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 168 18 in in IN cord-254317-n2knqj4z 168 19 Vero Vero NNP cord-254317-n2knqj4z 168 20 and and CC cord-254317-n2knqj4z 168 21 IPEC IPEC NNP cord-254317-n2knqj4z 168 22 - - HYPH cord-254317-n2knqj4z 168 23 DQ dq NN cord-254317-n2knqj4z 168 24 cells cell NNS cord-254317-n2knqj4z 169 1 The the DT cord-254317-n2knqj4z 169 2 growth growth NN cord-254317-n2knqj4z 169 3 kinetics kinetic NNS cord-254317-n2knqj4z 169 4 of of IN cord-254317-n2knqj4z 169 5 icPC22A icPC22A NNP cord-254317-n2knqj4z 169 6 - - HYPH cord-254317-n2knqj4z 169 7 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 169 8 and and CC cord-254317-n2knqj4z 169 9 icPC22A icPC22A NNP cord-254317-n2knqj4z 169 10 during during IN cord-254317-n2knqj4z 169 11 the the DT cord-254317-n2knqj4z 169 12 coinfection coinfection NN cord-254317-n2knqj4z 169 13 of of IN cord-254317-n2knqj4z 169 14 the the DT cord-254317-n2knqj4z 169 15 two two CD cord-254317-n2knqj4z 169 16 viruses virus NNS cord-254317-n2knqj4z 169 17 were be VBD cord-254317-n2knqj4z 169 18 investigated investigate VBN cord-254317-n2knqj4z 169 19 in in IN cord-254317-n2knqj4z 169 20 Vero Vero NNP cord-254317-n2knqj4z 169 21 and and CC cord-254317-n2knqj4z 169 22 IPEC IPEC NNP cord-254317-n2knqj4z 169 23 - - HYPH cord-254317-n2knqj4z 169 24 DQ dq NN cord-254317-n2knqj4z 169 25 cells cell NNS cord-254317-n2knqj4z 169 26 . . . cord-254317-n2knqj4z 170 1 Cell cell NN cord-254317-n2knqj4z 170 2 monolayers monolayer NNS cord-254317-n2knqj4z 170 3 on on IN cord-254317-n2knqj4z 170 4 96-well 96-well CD cord-254317-n2knqj4z 170 5 plates plate NNS cord-254317-n2knqj4z 170 6 were be VBD cord-254317-n2knqj4z 170 7 inoculated inoculate VBN cord-254317-n2knqj4z 170 8 with with IN cord-254317-n2knqj4z 170 9 one one CD cord-254317-n2knqj4z 170 10 of of IN cord-254317-n2knqj4z 170 11 the the DT cord-254317-n2knqj4z 170 12 three three CD cord-254317-n2knqj4z 170 13 inocula inocula NN cord-254317-n2knqj4z 170 14 : : : cord-254317-n2knqj4z 170 15 ( ( -LRB- cord-254317-n2knqj4z 170 16 1 1 CD cord-254317-n2knqj4z 170 17 ) ) -RRB- cord-254317-n2knqj4z 170 18 0.01 0.01 CD cord-254317-n2knqj4z 170 19 multiplicity multiplicity NN cord-254317-n2knqj4z 170 20 of of IN cord-254317-n2knqj4z 170 21 infection infection NN cord-254317-n2knqj4z 170 22 ( ( -LRB- cord-254317-n2knqj4z 170 23 MOI MOI NNP cord-254317-n2knqj4z 170 24 ) ) -RRB- cord-254317-n2knqj4z 170 25 of of IN cord-254317-n2knqj4z 170 26 icPC22A icPC22A NNP cord-254317-n2knqj4z 170 27 ; ; : cord-254317-n2knqj4z 170 28 ( ( -LRB- cord-254317-n2knqj4z 170 29 2 2 CD cord-254317-n2knqj4z 170 30 ) ) -RRB- cord-254317-n2knqj4z 170 31 0.01 0.01 CD cord-254317-n2knqj4z 170 32 MOI MOI NNP cord-254317-n2knqj4z 170 33 of of IN cord-254317-n2knqj4z 170 34 icPC22A icPC22A NNP cord-254317-n2knqj4z 170 35 - - HYPH cord-254317-n2knqj4z 170 36 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 170 37 ; ; : cord-254317-n2knqj4z 170 38 and and CC cord-254317-n2knqj4z 170 39 ( ( -LRB- cord-254317-n2knqj4z 170 40 3 3 CD cord-254317-n2knqj4z 170 41 ) ) -RRB- cord-254317-n2knqj4z 170 42 0.01 0.01 CD cord-254317-n2knqj4z 170 43 MOI MOI NNP cord-254317-n2knqj4z 170 44 of of IN cord-254317-n2knqj4z 170 45 icPC22A icPC22A NNP cord-254317-n2knqj4z 170 46 and and CC cord-254317-n2knqj4z 170 47 0.01 0.01 CD cord-254317-n2knqj4z 170 48 MOI MOI NNP cord-254317-n2knqj4z 170 49 of of IN cord-254317-n2knqj4z 170 50 icPC22 icpc22 NN cord-254317-n2knqj4z 171 1 A a LS cord-254317-n2knqj4z 171 2 - - HYPH cord-254317-n2knqj4z 171 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 171 4 . . . cord-254317-n2knqj4z 172 1 Viruses virus NNS cord-254317-n2knqj4z 172 2 were be VBD cord-254317-n2knqj4z 172 3 diluted dilute VBN cord-254317-n2knqj4z 172 4 in in IN cord-254317-n2knqj4z 172 5 DMEM DMEM NNP cord-254317-n2knqj4z 172 6 containing contain VBG cord-254317-n2knqj4z 172 7 10 10 CD cord-254317-n2knqj4z 173 1 μg μg NNP cord-254317-n2knqj4z 173 2 / / SYM cord-254317-n2knqj4z 173 3 mL ml NN cord-254317-n2knqj4z 173 4 trypsin trypsin NN cord-254317-n2knqj4z 173 5 and and CC cord-254317-n2knqj4z 173 6 were be VBD cord-254317-n2knqj4z 173 7 added add VBN cord-254317-n2knqj4z 173 8 to to IN cord-254317-n2knqj4z 173 9 cell cell NN cord-254317-n2knqj4z 173 10 monolayers monolayer NNS cord-254317-n2knqj4z 173 11 . . . cord-254317-n2knqj4z 174 1 After after IN cord-254317-n2knqj4z 174 2 incubating incubate VBG cord-254317-n2knqj4z 174 3 at at IN cord-254317-n2knqj4z 174 4 37 37 CD cord-254317-n2knqj4z 174 5 ℃ ℃ NNS cord-254317-n2knqj4z 174 6 for for IN cord-254317-n2knqj4z 174 7 2 2 CD cord-254317-n2knqj4z 174 8 h h NN cord-254317-n2knqj4z 174 9 , , , cord-254317-n2knqj4z 174 10 the the DT cord-254317-n2knqj4z 174 11 inoculum inoculum NN cord-254317-n2knqj4z 174 12 was be VBD cord-254317-n2knqj4z 174 13 removed remove VBN cord-254317-n2knqj4z 174 14 and and CC cord-254317-n2knqj4z 174 15 the the DT cord-254317-n2knqj4z 174 16 cell cell NN cord-254317-n2knqj4z 174 17 monolayers monolayer NNS cord-254317-n2knqj4z 174 18 were be VBD cord-254317-n2knqj4z 174 19 washed wash VBN cord-254317-n2knqj4z 174 20 for for IN cord-254317-n2knqj4z 174 21 three three CD cord-254317-n2knqj4z 174 22 times time NNS cord-254317-n2knqj4z 174 23 . . . cord-254317-n2knqj4z 175 1 Then then RB cord-254317-n2knqj4z 175 2 the the DT cord-254317-n2knqj4z 175 3 plates plate NNS cord-254317-n2knqj4z 175 4 were be VBD cord-254317-n2knqj4z 175 5 added add VBN cord-254317-n2knqj4z 175 6 with with IN cord-254317-n2knqj4z 175 7 the the DT cord-254317-n2knqj4z 175 8 maintenance maintenance NN cord-254317-n2knqj4z 175 9 medium medium NN cord-254317-n2knqj4z 175 10 and and CC cord-254317-n2knqj4z 175 11 incubated incubate VBN cord-254317-n2knqj4z 175 12 at at IN cord-254317-n2knqj4z 175 13 37 37 CD cord-254317-n2knqj4z 175 14 ℃ ℃ NNS cord-254317-n2knqj4z 175 15 . . . cord-254317-n2knqj4z 176 1 The the DT cord-254317-n2knqj4z 176 2 samples sample NNS cord-254317-n2knqj4z 176 3 were be VBD cord-254317-n2knqj4z 176 4 collected collect VBN cord-254317-n2knqj4z 176 5 at at IN cord-254317-n2knqj4z 176 6 different different JJ cord-254317-n2knqj4z 176 7 time time NN cord-254317-n2knqj4z 176 8 points point NNS cord-254317-n2knqj4z 176 9 ( ( -LRB- cord-254317-n2knqj4z 176 10 2 2 CD cord-254317-n2knqj4z 176 11 h h NNP cord-254317-n2knqj4z 176 12 , , , cord-254317-n2knqj4z 176 13 8 8 CD cord-254317-n2knqj4z 176 14 h h NN cord-254317-n2knqj4z 176 15 , , , cord-254317-n2knqj4z 176 16 12 12 CD cord-254317-n2knqj4z 176 17 h h NN cord-254317-n2knqj4z 176 18 , , , cord-254317-n2knqj4z 176 19 36 36 CD cord-254317-n2knqj4z 176 20 h h NN cord-254317-n2knqj4z 176 21 , , , cord-254317-n2knqj4z 176 22 48 48 CD cord-254317-n2knqj4z 176 23 h h NN cord-254317-n2knqj4z 176 24 ) ) -RRB- cord-254317-n2knqj4z 176 25 and and CC cord-254317-n2knqj4z 176 26 frozen freeze VBN cord-254317-n2knqj4z 176 27 ( ( -LRB- cord-254317-n2knqj4z 176 28 -80 -80 NNP cord-254317-n2knqj4z 176 29 ℃ ℃ NN cord-254317-n2knqj4z 176 30 ) ) -RRB- cord-254317-n2knqj4z 176 31 and and CC cord-254317-n2knqj4z 176 32 thawed thaw VBN cord-254317-n2knqj4z 176 33 once once RB cord-254317-n2knqj4z 176 34 before before IN cord-254317-n2knqj4z 176 35 testing testing NN cord-254317-n2knqj4z 176 36 . . . cord-254317-n2knqj4z 177 1 RNA RNA NNP cord-254317-n2knqj4z 177 2 was be VBD cord-254317-n2knqj4z 177 3 extracted extract VBN cord-254317-n2knqj4z 177 4 using use VBG cord-254317-n2knqj4z 177 5 the the DT cord-254317-n2knqj4z 177 6 MagMAX-96 MagMAX-96 NNP cord-254317-n2knqj4z 177 7 RNA RNA NNP cord-254317-n2knqj4z 177 8 isolation isolation NN cord-254317-n2knqj4z 177 9 kit kit NN cord-254317-n2knqj4z 177 10 ( ( -LRB- cord-254317-n2knqj4z 177 11 Thermo Thermo NNP cord-254317-n2knqj4z 177 12 Fisher Fisher NNP cord-254317-n2knqj4z 177 13 Scientific Scientific NNP cord-254317-n2knqj4z 177 14 ) ) -RRB- cord-254317-n2knqj4z 177 15 and and CC cord-254317-n2knqj4z 177 16 virus virus NN cord-254317-n2knqj4z 177 17 titers titer NNS cord-254317-n2knqj4z 177 18 were be VBD cord-254317-n2knqj4z 177 19 tested test VBN cord-254317-n2knqj4z 177 20 by by IN cord-254317-n2knqj4z 177 21 the the DT cord-254317-n2knqj4z 177 22 duplex duplex JJ cord-254317-n2knqj4z 177 23 RT RT NNP cord-254317-n2knqj4z 177 24 - - HYPH cord-254317-n2knqj4z 177 25 qPCR qpcr NN cord-254317-n2knqj4z 177 26 specific specific JJ cord-254317-n2knqj4z 177 27 for for IN cord-254317-n2knqj4z 177 28 both both DT cord-254317-n2knqj4z 177 29 viruses virus NNS cord-254317-n2knqj4z 177 30 . . . cord-254317-n2knqj4z 178 1 For for IN cord-254317-n2knqj4z 178 2 IF if IN cord-254317-n2knqj4z 178 3 staining staining NN cord-254317-n2knqj4z 178 4 of of IN cord-254317-n2knqj4z 178 5 S s NN cord-254317-n2knqj4z 178 6 proteins protein NNS cord-254317-n2knqj4z 178 7 at at IN cord-254317-n2knqj4z 178 8 8 8 CD cord-254317-n2knqj4z 178 9 h h NN cord-254317-n2knqj4z 178 10 post post NN cord-254317-n2knqj4z 178 11 infection infection NN cord-254317-n2knqj4z 178 12 ( ( -LRB- cord-254317-n2knqj4z 178 13 hpi hpi NNP cord-254317-n2knqj4z 178 14 ) ) -RRB- cord-254317-n2knqj4z 178 15 , , , cord-254317-n2knqj4z 178 16 the the DT cord-254317-n2knqj4z 178 17 procedure procedure NN cord-254317-n2knqj4z 178 18 in in IN cord-254317-n2knqj4z 178 19 2.4 2.4 CD cord-254317-n2knqj4z 178 20 section section NN cord-254317-n2knqj4z 178 21 was be VBD cord-254317-n2knqj4z 178 22 performed perform VBN cord-254317-n2knqj4z 178 23 . . . cord-254317-n2knqj4z 179 1 2.7 2.7 CD cord-254317-n2knqj4z 179 2 . . . cord-254317-n2knqj4z 180 1 Infection infection NN cord-254317-n2knqj4z 180 2 of of IN cord-254317-n2knqj4z 180 3 PEDV PEDV NNP cord-254317-n2knqj4z 180 4 icPC22A icPC22A NNP cord-254317-n2knqj4z 180 5 and and CC cord-254317-n2knqj4z 180 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 180 7 - - HYPH cord-254317-n2knqj4z 180 8 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 180 9 in in IN cord-254317-n2knqj4z 180 10 NA NA NNP cord-254317-n2knqj4z 180 11 - - HYPH cord-254317-n2knqj4z 180 12 treated treat VBN cord-254317-n2knqj4z 180 13 Vero Vero NNP cord-254317-n2knqj4z 180 14 and and CC cord-254317-n2knqj4z 180 15 IPEC IPEC NNP cord-254317-n2knqj4z 180 16 - - HYPH cord-254317-n2knqj4z 180 17 DQ dq NN cord-254317-n2knqj4z 180 18 cells cell NNS cord-254317-n2knqj4z 180 19 Vero Vero NNP cord-254317-n2knqj4z 180 20 / / SYM cord-254317-n2knqj4z 180 21 IPEC IPEC NNP cord-254317-n2knqj4z 180 22 - - HYPH cord-254317-n2knqj4z 180 23 DQ dq NN cord-254317-n2knqj4z 180 24 cell cell NN cord-254317-n2knqj4z 180 25 monolayers monolayer NNS cord-254317-n2knqj4z 180 26 in in IN cord-254317-n2knqj4z 180 27 96-well 96-well CD cord-254317-n2knqj4z 180 28 plates plate NNS cord-254317-n2knqj4z 180 29 were be VBD cord-254317-n2knqj4z 180 30 treated treat VBN cord-254317-n2knqj4z 180 31 with with IN cord-254317-n2knqj4z 180 32 250 250 CD cord-254317-n2knqj4z 180 33 mU mU NNP cord-254317-n2knqj4z 180 34 NA NA NNP cord-254317-n2knqj4z 180 35 in in IN cord-254317-n2knqj4z 180 36 DMEM DMEM NNP cord-254317-n2knqj4z 180 37 / / SYM cord-254317-n2knqj4z 180 38 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 180 39 or or CC cord-254317-n2knqj4z 180 40 mock mock VB cord-254317-n2knqj4z 180 41 DMEM DMEM NNP cord-254317-n2knqj4z 180 42 / / SYM cord-254317-n2knqj4z 180 43 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 180 44 at at IN cord-254317-n2knqj4z 180 45 37 37 CD cord-254317-n2knqj4z 180 46 ℃ ℃ NNS cord-254317-n2knqj4z 180 47 for for IN cord-254317-n2knqj4z 180 48 2 2 CD cord-254317-n2knqj4z 180 49 h. h. NN cord-254317-n2knqj4z 181 1 After after IN cord-254317-n2knqj4z 181 2 three three CD cord-254317-n2knqj4z 181 3 washings washing NNS cord-254317-n2knqj4z 181 4 with with IN cord-254317-n2knqj4z 181 5 DMEM DMEM NNP cord-254317-n2knqj4z 181 6 / / SYM cord-254317-n2knqj4z 181 7 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 181 8 , , , cord-254317-n2knqj4z 181 9 cells cell NNS cord-254317-n2knqj4z 181 10 were be VBD cord-254317-n2knqj4z 181 11 inoculated inoculate VBN cord-254317-n2knqj4z 181 12 with with IN cord-254317-n2knqj4z 181 13 icPC22 icpc22 NN cord-254317-n2knqj4z 182 1 A a NN cord-254317-n2knqj4z 182 2 or or CC cord-254317-n2knqj4z 182 3 icPC22 icpc22 NN cord-254317-n2knqj4z 183 1 A a LS cord-254317-n2knqj4z 183 2 - - HYPH cord-254317-n2knqj4z 183 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 183 4 at at IN cord-254317-n2knqj4z 183 5 a a DT cord-254317-n2knqj4z 183 6 MOI MOI NNP cord-254317-n2knqj4z 183 7 of of IN cord-254317-n2knqj4z 183 8 0.02 0.02 CD cord-254317-n2knqj4z 183 9 with with IN cord-254317-n2knqj4z 183 10 10 10 CD cord-254317-n2knqj4z 183 11 μg μg NN cord-254317-n2knqj4z 183 12 / / SYM cord-254317-n2knqj4z 183 13 mL ml NN cord-254317-n2knqj4z 183 14 trypsin trypsin NN cord-254317-n2knqj4z 183 15 for for IN cord-254317-n2knqj4z 183 16 2 2 CD cord-254317-n2knqj4z 183 17 h. h. NNP cord-254317-n2knqj4z 183 18 Next Next NNP cord-254317-n2knqj4z 183 19 , , , cord-254317-n2knqj4z 183 20 the the DT cord-254317-n2knqj4z 183 21 inoculum inoculum NN cord-254317-n2knqj4z 183 22 was be VBD cord-254317-n2knqj4z 183 23 removed remove VBN cord-254317-n2knqj4z 183 24 followed follow VBN cord-254317-n2knqj4z 183 25 by by IN cord-254317-n2knqj4z 183 26 three three CD cord-254317-n2knqj4z 183 27 washings washing NNS cord-254317-n2knqj4z 183 28 . . . cord-254317-n2knqj4z 184 1 DMEM DMEM NNP cord-254317-n2knqj4z 184 2 / / SYM cord-254317-n2knqj4z 184 3 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 184 4 containing contain VBG cord-254317-n2knqj4z 184 5 50 50 CD cord-254317-n2knqj4z 184 6 μg μg NNS cord-254317-n2knqj4z 184 7 / / SYM cord-254317-n2knqj4z 184 8 mL ml NN cord-254317-n2knqj4z 184 9 soybean soybean NN cord-254317-n2knqj4z 184 10 trypsin trypsin NN cord-254317-n2knqj4z 184 11 inhibitor inhibitor NN cord-254317-n2knqj4z 184 12 ( ( -LRB- cord-254317-n2knqj4z 184 13 SBTI SBTI NNP cord-254317-n2knqj4z 184 14 ) ) -RRB- cord-254317-n2knqj4z 184 15 and and CC cord-254317-n2knqj4z 184 16 swine swine VB cord-254317-n2knqj4z 184 17 PEDV PEDV NNP cord-254317-n2knqj4z 184 18 positive positive JJ cord-254317-n2knqj4z 184 19 serum serum NN cord-254317-n2knqj4z 184 20 ( ( -LRB- cord-254317-n2knqj4z 184 21 virus virus NN cord-254317-n2knqj4z 184 22 neutralization neutralization NN cord-254317-n2knqj4z 184 23 titer titer NN cord-254317-n2knqj4z 184 24 1:1024 1:1024 NNP cord-254317-n2knqj4z 184 25 , , , cord-254317-n2knqj4z 184 26 1:500 1:500 CD cord-254317-n2knqj4z 184 27 dilution dilution NN cord-254317-n2knqj4z 184 28 ) ) -RRB- cord-254317-n2knqj4z 184 29 was be VBD cord-254317-n2knqj4z 184 30 added add VBN cord-254317-n2knqj4z 184 31 to to TO cord-254317-n2knqj4z 184 32 prevent prevent VB cord-254317-n2knqj4z 184 33 virus virus NN cord-254317-n2knqj4z 184 34 spreading spread VBG cord-254317-n2knqj4z 184 35 . . . cord-254317-n2knqj4z 185 1 Cells cell NNS cord-254317-n2knqj4z 185 2 were be VBD cord-254317-n2knqj4z 185 3 fixed fix VBN cord-254317-n2knqj4z 185 4 with with IN cord-254317-n2knqj4z 185 5 acetone acetone NN cord-254317-n2knqj4z 185 6 - - HYPH cord-254317-n2knqj4z 185 7 methanol methanol NN cord-254317-n2knqj4z 185 8 ( ( -LRB- cord-254317-n2knqj4z 185 9 1:4 1:4 CD cord-254317-n2knqj4z 185 10 ) ) -RRB- cord-254317-n2knqj4z 185 11 at at IN cord-254317-n2knqj4z 185 12 6 6 CD cord-254317-n2knqj4z 185 13 hpi hpi NNP cord-254317-n2knqj4z 185 14 . . . cord-254317-n2knqj4z 186 1 The the DT cord-254317-n2knqj4z 186 2 numbers number NNS cord-254317-n2knqj4z 186 3 of of IN cord-254317-n2knqj4z 186 4 PEDV PEDV NNP cord-254317-n2knqj4z 186 5 - - HYPH cord-254317-n2knqj4z 186 6 infected infect VBN cord-254317-n2knqj4z 186 7 cell cell NN cord-254317-n2knqj4z 186 8 foci focus NNS cord-254317-n2knqj4z 186 9 were be VBD cord-254317-n2knqj4z 186 10 determined determine VBN cord-254317-n2knqj4z 186 11 by by IN cord-254317-n2knqj4z 186 12 IF if NN cord-254317-n2knqj4z 186 13 assays assay NNS cord-254317-n2knqj4z 186 14 as as IN cord-254317-n2knqj4z 186 15 described describe VBN cord-254317-n2knqj4z 186 16 for for IN cord-254317-n2knqj4z 186 17 the the DT cord-254317-n2knqj4z 186 18 staining staining NN cord-254317-n2knqj4z 186 19 of of IN cord-254317-n2knqj4z 186 20 PEDV PEDV NNP cord-254317-n2knqj4z 186 21 N n CD cord-254317-n2knqj4z 186 22 proteins protein NNS cord-254317-n2knqj4z 187 1 ( ( -LRB- cord-254317-n2knqj4z 187 2 Hou Hou NNP cord-254317-n2knqj4z 187 3 et et NNP cord-254317-n2knqj4z 187 4 al al NNP cord-254317-n2knqj4z 187 5 . . NNP cord-254317-n2knqj4z 187 6 , , , cord-254317-n2knqj4z 187 7 2017 2017 CD cord-254317-n2knqj4z 187 8 ) ) -RRB- cord-254317-n2knqj4z 187 9 . . . cord-254317-n2knqj4z 188 1 Briefly briefly RB cord-254317-n2knqj4z 188 2 , , , cord-254317-n2knqj4z 188 3 rabbit rabbit NN cord-254317-n2knqj4z 188 4 PAb PAb NNS cord-254317-n2knqj4z 188 5 RB9 RB9 NNP cord-254317-n2knqj4z 188 6 ( ( -LRB- cord-254317-n2knqj4z 188 7 1:1000 1:1000 NN cord-254317-n2knqj4z 188 8 ) ) -RRB- cord-254317-n2knqj4z 188 9 was be VBD cord-254317-n2knqj4z 188 10 used use VBN cord-254317-n2knqj4z 188 11 as as IN cord-254317-n2knqj4z 188 12 the the DT cord-254317-n2knqj4z 188 13 primary primary JJ cord-254317-n2knqj4z 188 14 antibody antibody NN cord-254317-n2knqj4z 188 15 . . . cord-254317-n2knqj4z 189 1 After after IN cord-254317-n2knqj4z 189 2 incubating incubate VBG cord-254317-n2knqj4z 189 3 at at IN cord-254317-n2knqj4z 189 4 4 4 CD cord-254317-n2knqj4z 189 5 ℃ ℃ NNS cord-254317-n2knqj4z 189 6 overnight overnight RB cord-254317-n2knqj4z 189 7 , , , cord-254317-n2knqj4z 189 8 cells cell NNS cord-254317-n2knqj4z 189 9 were be VBD cord-254317-n2knqj4z 189 10 washed wash VBN cord-254317-n2knqj4z 189 11 three three CD cord-254317-n2knqj4z 189 12 times time NNS cord-254317-n2knqj4z 189 13 . . . cord-254317-n2knqj4z 190 1 Then then RB cord-254317-n2knqj4z 190 2 Alexa Alexa NNP cord-254317-n2knqj4z 190 3 Fluor Fluor NNP cord-254317-n2knqj4z 190 4 488-conjugated 488-conjugated CD cord-254317-n2knqj4z 190 5 goat goat NNP cord-254317-n2knqj4z 190 6 anti anti JJ cord-254317-n2knqj4z 190 7 - - JJ cord-254317-n2knqj4z 190 8 rabbit rabbit JJ cord-254317-n2knqj4z 190 9 IgG igg NN cord-254317-n2knqj4z 190 10 ( ( -LRB- cord-254317-n2knqj4z 190 11 H H NNP cord-254317-n2knqj4z 190 12 + + CC cord-254317-n2knqj4z 190 13 L l NN cord-254317-n2knqj4z 190 14 ) ) -RRB- cord-254317-n2knqj4z 191 1 ( ( -LRB- cord-254317-n2knqj4z 191 2 Thermo Thermo NNP cord-254317-n2knqj4z 191 3 Fisher Fisher NNP cord-254317-n2knqj4z 191 4 Scientific Scientific NNP cord-254317-n2knqj4z 191 5 ) ) -RRB- cord-254317-n2knqj4z 191 6 ( ( -LRB- cord-254317-n2knqj4z 191 7 1:1000 1:1000 NN cord-254317-n2knqj4z 191 8 ) ) -RRB- cord-254317-n2knqj4z 191 9 was be VBD cord-254317-n2knqj4z 191 10 used use VBN cord-254317-n2knqj4z 191 11 as as IN cord-254317-n2knqj4z 191 12 the the DT cord-254317-n2knqj4z 191 13 2 2 CD cord-254317-n2knqj4z 191 14 nd nd NNP cord-254317-n2knqj4z 191 15 antibody antibody NN cord-254317-n2knqj4z 191 16 and and CC cord-254317-n2knqj4z 191 17 the the DT cord-254317-n2knqj4z 191 18 cells cell NNS cord-254317-n2knqj4z 191 19 were be VBD cord-254317-n2knqj4z 191 20 incubated incubate VBN cord-254317-n2knqj4z 191 21 at at IN cord-254317-n2knqj4z 191 22 room room NN cord-254317-n2knqj4z 191 23 temperature temperature NN cord-254317-n2knqj4z 191 24 for for IN cord-254317-n2knqj4z 191 25 1 1 CD cord-254317-n2knqj4z 191 26 h. h. NN cord-254317-n2knqj4z 191 27 After after IN cord-254317-n2knqj4z 191 28 washing wash VBG cord-254317-n2knqj4z 191 29 and and CC cord-254317-n2knqj4z 191 30 adding add VBG cord-254317-n2knqj4z 191 31 mounting mount VBG cord-254317-n2knqj4z 191 32 medium medium NN cord-254317-n2knqj4z 191 33 , , , cord-254317-n2knqj4z 191 34 cells cell NNS cord-254317-n2knqj4z 191 35 were be VBD cord-254317-n2knqj4z 191 36 observed observe VBN cord-254317-n2knqj4z 191 37 and and CC cord-254317-n2knqj4z 191 38 picture picture NN cord-254317-n2knqj4z 191 39 were be VBD cord-254317-n2knqj4z 191 40 captured capture VBN cord-254317-n2knqj4z 191 41 by by IN cord-254317-n2knqj4z 191 42 using use VBG cord-254317-n2knqj4z 191 43 Olympus Olympus NNP cord-254317-n2knqj4z 191 44 IX-70 IX-70 NNP cord-254317-n2knqj4z 191 45 fluorescent fluorescent JJ cord-254317-n2knqj4z 191 46 microscope microscope NN cord-254317-n2knqj4z 191 47 . . . cord-254317-n2knqj4z 192 1 The the DT cord-254317-n2knqj4z 192 2 numbers number NNS cord-254317-n2knqj4z 192 3 of of IN cord-254317-n2knqj4z 192 4 fluorescent fluorescent JJ cord-254317-n2knqj4z 192 5 focus focus NN cord-254317-n2knqj4z 192 6 units unit NNS cord-254317-n2knqj4z 192 7 ( ( -LRB- cord-254317-n2knqj4z 192 8 FFU FFU NNP cord-254317-n2knqj4z 192 9 ) ) -RRB- cord-254317-n2knqj4z 192 10 were be VBD cord-254317-n2knqj4z 192 11 counted count VBN cord-254317-n2knqj4z 192 12 by by IN cord-254317-n2knqj4z 192 13 ImageJ imagej DT cord-254317-n2knqj4z 192 14 software software NN cord-254317-n2knqj4z 192 15 . . . cord-254317-n2knqj4z 193 1 The the DT cord-254317-n2knqj4z 193 2 percentages percentage NNS cord-254317-n2knqj4z 193 3 of of IN cord-254317-n2knqj4z 193 4 FFU FFU NNP cord-254317-n2knqj4z 193 5 were be VBD cord-254317-n2knqj4z 193 6 calculated calculate VBN cord-254317-n2knqj4z 193 7 by by IN cord-254317-n2knqj4z 193 8 the the DT cord-254317-n2knqj4z 193 9 value value NN cord-254317-n2knqj4z 193 10 of of IN cord-254317-n2knqj4z 193 11 mock mock JJ cord-254317-n2knqj4z 193 12 group group NN cord-254317-n2knqj4z 193 13 as as IN cord-254317-n2knqj4z 193 14 100 100 CD cord-254317-n2knqj4z 193 15 % % NN cord-254317-n2knqj4z 193 16 . . . cord-254317-n2knqj4z 194 1 2.8 2.8 CD cord-254317-n2knqj4z 194 2 . . . cord-254317-n2knqj4z 195 1 Effect effect NN cord-254317-n2knqj4z 195 2 of of IN cord-254317-n2knqj4z 195 3 mucin mucin NN cord-254317-n2knqj4z 195 4 , , , cord-254317-n2knqj4z 195 5 bile bile NN cord-254317-n2knqj4z 195 6 and and CC cord-254317-n2knqj4z 195 7 bile bile NN cord-254317-n2knqj4z 195 8 acids acid NNS cord-254317-n2knqj4z 195 9 on on IN cord-254317-n2knqj4z 195 10 the the DT cord-254317-n2knqj4z 195 11 infection infection NN cord-254317-n2knqj4z 195 12 of of IN cord-254317-n2knqj4z 195 13 PEDV PEDV NNP cord-254317-n2knqj4z 195 14 icPC22A icPC22A NNP cord-254317-n2knqj4z 195 15 and and CC cord-254317-n2knqj4z 195 16 icPC22A icPC22A NNP cord-254317-n2knqj4z 195 17 - - HYPH cord-254317-n2knqj4z 195 18 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 195 19 in in IN cord-254317-n2knqj4z 195 20 Vero Vero NNP cord-254317-n2knqj4z 195 21 and and CC cord-254317-n2knqj4z 195 22 IPEC IPEC NNP cord-254317-n2knqj4z 195 23 - - HYPH cord-254317-n2knqj4z 195 24 DQ dq NN cord-254317-n2knqj4z 195 25 cells cell NNS cord-254317-n2knqj4z 196 1 Viruses virus NNS cord-254317-n2knqj4z 196 2 ( ( -LRB- cord-254317-n2knqj4z 196 3 icPC22A icPC22A NNP cord-254317-n2knqj4z 196 4 or or CC cord-254317-n2knqj4z 196 5 icPC22A icPC22A NNP cord-254317-n2knqj4z 196 6 - - HYPH cord-254317-n2knqj4z 196 7 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 196 8 ) ) -RRB- cord-254317-n2knqj4z 196 9 were be VBD cord-254317-n2knqj4z 196 10 mixed mix VBN cord-254317-n2knqj4z 196 11 with with IN cord-254317-n2knqj4z 196 12 different different JJ cord-254317-n2knqj4z 196 13 concentrations concentration NNS cord-254317-n2knqj4z 196 14 of of IN cord-254317-n2knqj4z 196 15 BM BM NNP cord-254317-n2knqj4z 196 16 ( ( -LRB- cord-254317-n2knqj4z 196 17 0 0 NFP cord-254317-n2knqj4z 196 18 , , , cord-254317-n2knqj4z 196 19 0.1 0.1 CD cord-254317-n2knqj4z 196 20 , , , cord-254317-n2knqj4z 196 21 0.3 0.3 CD cord-254317-n2knqj4z 196 22 , , , cord-254317-n2knqj4z 196 23 0.5 0.5 CD cord-254317-n2knqj4z 196 24 mg mg NNP cord-254317-n2knqj4z 196 25 / / SYM cord-254317-n2knqj4z 196 26 mL mL NNP cord-254317-n2knqj4z 196 27 ) ) -RRB- cord-254317-n2knqj4z 196 28 or or CC cord-254317-n2knqj4z 196 29 PGM PGM NNP cord-254317-n2knqj4z 196 30 ( ( -LRB- cord-254317-n2knqj4z 196 31 0 0 NFP cord-254317-n2knqj4z 196 32 , , , cord-254317-n2knqj4z 196 33 0.5 0.5 CD cord-254317-n2knqj4z 196 34 , , , cord-254317-n2knqj4z 196 35 1.0 1.0 CD cord-254317-n2knqj4z 196 36 , , , cord-254317-n2knqj4z 196 37 2.5 2.5 CD cord-254317-n2knqj4z 196 38 , , , cord-254317-n2knqj4z 196 39 5.0 5.0 CD cord-254317-n2knqj4z 196 40 mg mg NN cord-254317-n2knqj4z 196 41 / / SYM cord-254317-n2knqj4z 196 42 mL mL NNP cord-254317-n2knqj4z 196 43 ) ) -RRB- cord-254317-n2knqj4z 196 44 . . . cord-254317-n2knqj4z 197 1 Then then RB cord-254317-n2knqj4z 197 2 10 10 CD cord-254317-n2knqj4z 197 3 μg μg NN cord-254317-n2knqj4z 197 4 / / SYM cord-254317-n2knqj4z 197 5 mL ml NN cord-254317-n2knqj4z 197 6 trypsin trypsin NNS cord-254317-n2knqj4z 197 7 were be VBD cord-254317-n2knqj4z 197 8 added add VBN cord-254317-n2knqj4z 197 9 to to IN cord-254317-n2knqj4z 197 10 the the DT cord-254317-n2knqj4z 197 11 mixture mixture NN cord-254317-n2knqj4z 197 12 . . . cord-254317-n2knqj4z 198 1 Monolayer Monolayer NNP cord-254317-n2knqj4z 198 2 of of IN cord-254317-n2knqj4z 198 3 Vero Vero NNP cord-254317-n2knqj4z 198 4 / / SYM cord-254317-n2knqj4z 198 5 IPEC IPEC NNP cord-254317-n2knqj4z 198 6 - - HYPH cord-254317-n2knqj4z 198 7 DQ dq NN cord-254317-n2knqj4z 198 8 cells cell NNS cord-254317-n2knqj4z 198 9 in in IN cord-254317-n2knqj4z 198 10 96-well 96-well CD cord-254317-n2knqj4z 198 11 plates plate NNS cord-254317-n2knqj4z 198 12 were be VBD cord-254317-n2knqj4z 198 13 inoculated inoculate VBN cord-254317-n2knqj4z 198 14 with with IN cord-254317-n2knqj4z 198 15 each each DT cord-254317-n2knqj4z 198 16 virus virus NN cord-254317-n2knqj4z 198 17 mixture mixture NN cord-254317-n2knqj4z 198 18 at at IN cord-254317-n2knqj4z 198 19 a a DT cord-254317-n2knqj4z 198 20 MOI MOI NNP cord-254317-n2knqj4z 198 21 of of IN cord-254317-n2knqj4z 198 22 0.02 0.02 CD cord-254317-n2knqj4z 198 23 . . . cord-254317-n2knqj4z 199 1 The the DT cord-254317-n2knqj4z 199 2 plates plate NNS cord-254317-n2knqj4z 199 3 were be VBD cord-254317-n2knqj4z 199 4 incubated incubate VBN cord-254317-n2knqj4z 199 5 at at IN cord-254317-n2knqj4z 199 6 37 37 CD cord-254317-n2knqj4z 199 7 ℃ ℃ NNS cord-254317-n2knqj4z 199 8 for for IN cord-254317-n2knqj4z 199 9 2 2 CD cord-254317-n2knqj4z 199 10 h h NN cord-254317-n2knqj4z 199 11 , , , cord-254317-n2knqj4z 199 12 then then RB cord-254317-n2knqj4z 199 13 the the DT cord-254317-n2knqj4z 199 14 inoculum inoculum NN cord-254317-n2knqj4z 199 15 was be VBD cord-254317-n2knqj4z 199 16 removed remove VBN cord-254317-n2knqj4z 199 17 . . . cord-254317-n2knqj4z 200 1 After after IN cord-254317-n2knqj4z 200 2 three three CD cord-254317-n2knqj4z 200 3 washings washing NNS cord-254317-n2knqj4z 200 4 , , , cord-254317-n2knqj4z 200 5 DMEM DMEM NNP cord-254317-n2knqj4z 200 6 / / SYM cord-254317-n2knqj4z 200 7 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 200 8 containing contain VBG cord-254317-n2knqj4z 200 9 50 50 CD cord-254317-n2knqj4z 200 10 μg μg NNS cord-254317-n2knqj4z 200 11 / / SYM cord-254317-n2knqj4z 200 12 mL mL NNP cord-254317-n2knqj4z 200 13 SBTI SBTI NNP cord-254317-n2knqj4z 200 14 and and CC cord-254317-n2knqj4z 200 15 swine swine NN cord-254317-n2knqj4z 200 16 PEDV PEDV NNP cord-254317-n2knqj4z 200 17 positive positive JJ cord-254317-n2knqj4z 200 18 serum serum NN cord-254317-n2knqj4z 200 19 ( ( -LRB- cord-254317-n2knqj4z 200 20 1:500 1:500 CD cord-254317-n2knqj4z 200 21 dilution dilution NN cord-254317-n2knqj4z 200 22 ) ) -RRB- cord-254317-n2knqj4z 200 23 was be VBD cord-254317-n2knqj4z 200 24 added add VBN cord-254317-n2knqj4z 200 25 . . . cord-254317-n2knqj4z 201 1 Cells cell NNS cord-254317-n2knqj4z 201 2 were be VBD cord-254317-n2knqj4z 201 3 fixed fix VBN cord-254317-n2knqj4z 201 4 at at IN cord-254317-n2knqj4z 201 5 6 6 CD cord-254317-n2knqj4z 201 6 hpi hpi NNP cord-254317-n2knqj4z 201 7 . . . cord-254317-n2knqj4z 202 1 The the DT cord-254317-n2knqj4z 202 2 numbers number NNS cord-254317-n2knqj4z 202 3 of of IN cord-254317-n2knqj4z 202 4 FFU FFU NNP cord-254317-n2knqj4z 202 5 were be VBD cord-254317-n2knqj4z 202 6 determined determine VBN cord-254317-n2knqj4z 202 7 by by IN cord-254317-n2knqj4z 202 8 IF if IN cord-254317-n2knqj4z 202 9 assay assay NN cord-254317-n2knqj4z 202 10 for for IN cord-254317-n2knqj4z 202 11 the the DT cord-254317-n2knqj4z 202 12 staining staining NN cord-254317-n2knqj4z 202 13 of of IN cord-254317-n2knqj4z 202 14 PEDV PEDV NNP cord-254317-n2knqj4z 202 15 N n CD cord-254317-n2knqj4z 202 16 proteins protein NNS cord-254317-n2knqj4z 202 17 ( ( -LRB- cord-254317-n2knqj4z 202 18 see see VB cord-254317-n2knqj4z 202 19 section section NN cord-254317-n2knqj4z 202 20 2.7 2.7 CD cord-254317-n2knqj4z 202 21 ) ) -RRB- cord-254317-n2knqj4z 202 22 . . . cord-254317-n2knqj4z 203 1 The the DT cord-254317-n2knqj4z 203 2 percentages percentage NNS cord-254317-n2knqj4z 203 3 of of IN cord-254317-n2knqj4z 203 4 FFU FFU NNP cord-254317-n2knqj4z 203 5 were be VBD cord-254317-n2knqj4z 203 6 calculated calculate VBN cord-254317-n2knqj4z 203 7 by by IN cord-254317-n2knqj4z 203 8 the the DT cord-254317-n2knqj4z 203 9 value value NN cord-254317-n2knqj4z 203 10 of of IN cord-254317-n2knqj4z 203 11 mock mock JJ cord-254317-n2knqj4z 203 12 group group NN cord-254317-n2knqj4z 203 13 as as IN cord-254317-n2knqj4z 203 14 100 100 CD cord-254317-n2knqj4z 203 15 % % NN cord-254317-n2knqj4z 203 16 . . . cord-254317-n2knqj4z 204 1 Similarly similarly RB cord-254317-n2knqj4z 204 2 , , , cord-254317-n2knqj4z 204 3 different different JJ cord-254317-n2knqj4z 204 4 concentration concentration NN cord-254317-n2knqj4z 204 5 of of IN cord-254317-n2knqj4z 204 6 swine swine NN cord-254317-n2knqj4z 204 7 bile bile NN cord-254317-n2knqj4z 204 8 ( ( -LRB- cord-254317-n2knqj4z 204 9 0 0 CD cord-254317-n2knqj4z 204 10 , , , cord-254317-n2knqj4z 204 11 0.1 0.1 CD cord-254317-n2knqj4z 204 12 , , , cord-254317-n2knqj4z 204 13 0.3 0.3 CD cord-254317-n2knqj4z 204 14 , , , cord-254317-n2knqj4z 204 15 0.5 0.5 CD cord-254317-n2knqj4z 204 16 , , , cord-254317-n2knqj4z 204 17 1.0 1.0 CD cord-254317-n2knqj4z 204 18 % % NN cord-254317-n2knqj4z 204 19 ) ) -RRB- cord-254317-n2knqj4z 204 20 and and CC cord-254317-n2knqj4z 204 21 bile bile NN cord-254317-n2knqj4z 204 22 acids acid NNS cord-254317-n2knqj4z 204 23 ( ( -LRB- cord-254317-n2knqj4z 204 24 GCDCA GCDCA NNP cord-254317-n2knqj4z 204 25 , , , cord-254317-n2knqj4z 204 26 CDCA CDCA NNP cord-254317-n2knqj4z 204 27 , , , cord-254317-n2knqj4z 204 28 DCA DCA NNP cord-254317-n2knqj4z 204 29 , , , cord-254317-n2knqj4z 204 30 and and CC cord-254317-n2knqj4z 204 31 UDCA UDCA NNP cord-254317-n2knqj4z 204 32 ) ) -RRB- cord-254317-n2knqj4z 204 33 at at IN cord-254317-n2knqj4z 204 34 0 0 CD cord-254317-n2knqj4z 204 35 , , , cord-254317-n2knqj4z 204 36 25 25 CD cord-254317-n2knqj4z 204 37 , , , cord-254317-n2knqj4z 204 38 50 50 CD cord-254317-n2knqj4z 204 39 , , , cord-254317-n2knqj4z 204 40 100 100 CD cord-254317-n2knqj4z 204 41 , , , cord-254317-n2knqj4z 204 42 200 200 CD cord-254317-n2knqj4z 204 43 μM μm CD cord-254317-n2knqj4z 204 44 were be VBD cord-254317-n2knqj4z 204 45 tested test VBN cord-254317-n2knqj4z 204 46 . . . cord-254317-n2knqj4z 205 1 Statistical statistical JJ cord-254317-n2knqj4z 205 2 analysis analysis NN cord-254317-n2knqj4z 205 3 was be VBD cord-254317-n2knqj4z 205 4 performed perform VBN cord-254317-n2knqj4z 205 5 using use VBG cord-254317-n2knqj4z 205 6 GraphPad GraphPad NNP cord-254317-n2knqj4z 205 7 Prism Prism NNP cord-254317-n2knqj4z 205 8 7 7 CD cord-254317-n2knqj4z 205 9 software software NN cord-254317-n2knqj4z 205 10 ( ( -LRB- cord-254317-n2knqj4z 205 11 GraphPad GraphPad NNP cord-254317-n2knqj4z 205 12 Software Software NNP cord-254317-n2knqj4z 205 13 , , , cord-254317-n2knqj4z 205 14 La La NNP cord-254317-n2knqj4z 205 15 Jolla Jolla NNP cord-254317-n2knqj4z 205 16 , , , cord-254317-n2knqj4z 205 17 CA CA NNP cord-254317-n2knqj4z 205 18 , , , cord-254317-n2knqj4z 205 19 USA USA NNP cord-254317-n2knqj4z 205 20 ) ) -RRB- cord-254317-n2knqj4z 205 21 . . . cord-254317-n2knqj4z 206 1 The the DT cord-254317-n2knqj4z 206 2 experimental experimental JJ cord-254317-n2knqj4z 206 3 data datum NNS cord-254317-n2knqj4z 206 4 were be VBD cord-254317-n2knqj4z 206 5 analyzed analyze VBN cord-254317-n2knqj4z 206 6 by by IN cord-254317-n2knqj4z 206 7 one one CD cord-254317-n2knqj4z 206 8 - - HYPH cord-254317-n2knqj4z 206 9 way way NN cord-254317-n2knqj4z 206 10 ANOVA anova NN cord-254317-n2knqj4z 206 11 and and CC cord-254317-n2knqj4z 206 12 Student`s student`s VB cord-254317-n2knqj4z 206 13 t t NN cord-254317-n2knqj4z 206 14 - - HYPH cord-254317-n2knqj4z 206 15 test test NN cord-254317-n2knqj4z 206 16 . . . cord-254317-n2knqj4z 207 1 Data datum NNS cord-254317-n2knqj4z 207 2 are be VBP cord-254317-n2knqj4z 207 3 shown show VBN cord-254317-n2knqj4z 207 4 as as IN cord-254317-n2knqj4z 207 5 M M NNP cord-254317-n2knqj4z 207 6 ± ± NNP cord-254317-n2knqj4z 207 7 SD SD NNP cord-254317-n2knqj4z 207 8 , , , cord-254317-n2knqj4z 207 9 and and CC cord-254317-n2knqj4z 207 10 a a DT cord-254317-n2knqj4z 207 11 P p NN cord-254317-n2knqj4z 207 12 < < XX cord-254317-n2knqj4z 207 13 0.05 0.05 CD cord-254317-n2knqj4z 207 14 was be VBD cord-254317-n2knqj4z 207 15 considered consider VBN cord-254317-n2knqj4z 207 16 as as RB cord-254317-n2knqj4z 207 17 significant significant JJ cord-254317-n2knqj4z 207 18 . . . cord-254317-n2knqj4z 208 1 3.1 3.1 LS cord-254317-n2knqj4z 208 2 . . . cord-254317-n2knqj4z 209 1 The the DT cord-254317-n2knqj4z 209 2 replication replication NN cord-254317-n2knqj4z 209 3 of of IN cord-254317-n2knqj4z 209 4 icPC22A icPC22A NNP cord-254317-n2knqj4z 209 5 was be VBD cord-254317-n2knqj4z 209 6 eventually eventually RB cord-254317-n2knqj4z 209 7 enhanced enhance VBN cord-254317-n2knqj4z 209 8 during during IN cord-254317-n2knqj4z 209 9 coinfection coinfection NN cord-254317-n2knqj4z 209 10 with with IN cord-254317-n2knqj4z 209 11 icPC22A icPC22A NNP cord-254317-n2knqj4z 209 12 - - HYPH cord-254317-n2knqj4z 209 13 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 209 14 in in IN cord-254317-n2knqj4z 209 15 neonatal neonatal JJ cord-254317-n2knqj4z 209 16 Gn Gn NNP cord-254317-n2knqj4z 209 17 piglets piglet NNS cord-254317-n2knqj4z 210 1 As as IN cord-254317-n2knqj4z 210 2 shown show VBN cord-254317-n2knqj4z 210 3 in in IN cord-254317-n2knqj4z 210 4 Fig Fig NNP cord-254317-n2knqj4z 210 5 . . . cord-254317-n2knqj4z 211 1 1 1 CD cord-254317-n2knqj4z 211 2 , , , cord-254317-n2knqj4z 211 3 all all DT cord-254317-n2knqj4z 211 4 PEDV PEDV NNP cord-254317-n2knqj4z 211 5 - - HYPH cord-254317-n2knqj4z 211 6 inoculated inoculate VBN cord-254317-n2knqj4z 211 7 pigs pig NNS cord-254317-n2knqj4z 211 8 but but CC cord-254317-n2knqj4z 211 9 no no DT cord-254317-n2knqj4z 211 10 pigs pig NNS cord-254317-n2knqj4z 211 11 in in IN cord-254317-n2knqj4z 211 12 the the DT cord-254317-n2knqj4z 211 13 mock mock JJ cord-254317-n2knqj4z 211 14 group group NN cord-254317-n2knqj4z 211 15 had have VBD cord-254317-n2knqj4z 211 16 diarrhea diarrhea NN cord-254317-n2knqj4z 211 17 and and CC cord-254317-n2knqj4z 211 18 shed shed VB cord-254317-n2knqj4z 211 19 PEDV PEDV NNP cord-254317-n2knqj4z 211 20 . . . cord-254317-n2knqj4z 212 1 The the DT cord-254317-n2knqj4z 212 2 fecal fecal JJ cord-254317-n2knqj4z 212 3 consistency consistency NN cord-254317-n2knqj4z 212 4 scores score NNS cord-254317-n2knqj4z 212 5 and and CC cord-254317-n2knqj4z 212 6 peak peak NN cord-254317-n2knqj4z 212 7 fecal fecal JJ cord-254317-n2knqj4z 212 8 PEDV PEDV NNP cord-254317-n2knqj4z 212 9 N N NNP cord-254317-n2knqj4z 212 10 and and CC cord-254317-n2knqj4z 212 11 S S NNP cord-254317-n2knqj4z 212 12 RNA RNA NNP cord-254317-n2knqj4z 212 13 shedding shed VBG cord-254317-n2knqj4z 212 14 titers titer NNS cord-254317-n2knqj4z 212 15 of of IN cord-254317-n2knqj4z 212 16 piglets piglet NNS cord-254317-n2knqj4z 212 17 in in IN cord-254317-n2knqj4z 212 18 the the DT cord-254317-n2knqj4z 212 19 coinfection coinfection NN cord-254317-n2knqj4z 212 20 group group NN cord-254317-n2knqj4z 213 1 reached reach VBD cord-254317-n2knqj4z 213 2 the the DT cord-254317-n2knqj4z 213 3 peak peak NN cord-254317-n2knqj4z 213 4 at at IN cord-254317-n2knqj4z 213 5 1.5 1.5 CD cord-254317-n2knqj4z 213 6 dpi dpi NN cord-254317-n2knqj4z 213 7 , , , cord-254317-n2knqj4z 213 8 which which WDT cord-254317-n2knqj4z 213 9 was be VBD cord-254317-n2knqj4z 213 10 delayed delay VBN cord-254317-n2knqj4z 213 11 half half PDT cord-254317-n2knqj4z 213 12 a a DT cord-254317-n2knqj4z 213 13 day day NN cord-254317-n2knqj4z 213 14 compared compare VBN cord-254317-n2knqj4z 213 15 with with IN cord-254317-n2knqj4z 213 16 the the DT cord-254317-n2knqj4z 213 17 icPC22A icPC22A NNP cord-254317-n2knqj4z 213 18 group group NN cord-254317-n2knqj4z 213 19 ( ( -LRB- cord-254317-n2knqj4z 213 20 1 1 CD cord-254317-n2knqj4z 213 21 dpi dpi NN cord-254317-n2knqj4z 213 22 ) ) -RRB- cord-254317-n2knqj4z 213 23 but but CC cord-254317-n2knqj4z 213 24 earlier early RBR cord-254317-n2knqj4z 213 25 than than IN cord-254317-n2knqj4z 213 26 the the DT cord-254317-n2knqj4z 213 27 icPC22A icPC22A NNP cord-254317-n2knqj4z 213 28 - - HYPH cord-254317-n2knqj4z 213 29 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 213 30 group group NN cord-254317-n2knqj4z 213 31 ( ( -LRB- cord-254317-n2knqj4z 213 32 > > NFP cord-254317-n2knqj4z 213 33 4 4 CD cord-254317-n2knqj4z 213 34 dpi dpi NN cord-254317-n2knqj4z 213 35 ) ) -RRB- cord-254317-n2knqj4z 213 36 . . . cord-254317-n2knqj4z 214 1 By by IN cord-254317-n2knqj4z 214 2 4 4 CD cord-254317-n2knqj4z 214 3 dpi dpi NN cord-254317-n2knqj4z 214 4 , , , cord-254317-n2knqj4z 214 5 all all DT cord-254317-n2knqj4z 214 6 pigs pig NNS cord-254317-n2knqj4z 214 7 in in IN cord-254317-n2knqj4z 214 8 the the DT cord-254317-n2knqj4z 214 9 icPC22A icPC22A NNP cord-254317-n2knqj4z 214 10 and and CC cord-254317-n2knqj4z 214 11 coinfection coinfection NN cord-254317-n2knqj4z 214 12 groups group NNS cord-254317-n2knqj4z 214 13 but but CC cord-254317-n2knqj4z 214 14 no no DT cord-254317-n2knqj4z 214 15 pigs pig NNS cord-254317-n2knqj4z 214 16 in in IN cord-254317-n2knqj4z 214 17 the the DT cord-254317-n2knqj4z 214 18 icPC22A icPC22A NNP cord-254317-n2knqj4z 214 19 - - HYPH cord-254317-n2knqj4z 214 20 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 214 21 group group NN cord-254317-n2knqj4z 214 22 died die VBD cord-254317-n2knqj4z 214 23 or or CC cord-254317-n2knqj4z 214 24 showed show VBD cord-254317-n2knqj4z 214 25 moribund moribund JJ cord-254317-n2knqj4z 214 26 . . . cord-254317-n2knqj4z 215 1 Compared compare VBN cord-254317-n2knqj4z 215 2 with with IN cord-254317-n2knqj4z 215 3 the the DT cord-254317-n2knqj4z 215 4 peak peak NN cord-254317-n2knqj4z 215 5 fecal fecal JJ cord-254317-n2knqj4z 215 6 PEDV PEDV NNP cord-254317-n2knqj4z 215 7 N N NNP cord-254317-n2knqj4z 215 8 gene gene NN cord-254317-n2knqj4z 215 9 shedding shed VBG cord-254317-n2knqj4z 215 10 titer titer NN cord-254317-n2knqj4z 215 11 ( ( -LRB- cord-254317-n2knqj4z 215 12 11.6 11.6 CD cord-254317-n2knqj4z 215 13 ± ± NNP cord-254317-n2knqj4z 215 14 0.2 0.2 CD cord-254317-n2knqj4z 215 15 log log NN cord-254317-n2knqj4z 215 16 10 10 CD cord-254317-n2knqj4z 215 17 copies copy NNS cord-254317-n2knqj4z 215 18 / / SYM cord-254317-n2knqj4z 215 19 mL ml NN cord-254317-n2knqj4z 215 20 ) ) -RRB- cord-254317-n2knqj4z 215 21 of of IN cord-254317-n2knqj4z 215 22 piglets piglet NNS cord-254317-n2knqj4z 215 23 in in IN cord-254317-n2knqj4z 215 24 the the DT cord-254317-n2knqj4z 215 25 icPC22A icPC22A NNP cord-254317-n2knqj4z 215 26 group group NN cord-254317-n2knqj4z 215 27 ( ( -LRB- cord-254317-n2knqj4z 215 28 1 1 CD cord-254317-n2knqj4z 215 29 dpi dpi NN cord-254317-n2knqj4z 215 30 ) ) -RRB- cord-254317-n2knqj4z 215 31 , , , cord-254317-n2knqj4z 215 32 pigs pig NNS cord-254317-n2knqj4z 215 33 in in IN cord-254317-n2knqj4z 215 34 the the DT cord-254317-n2knqj4z 215 35 coinfection coinfection NN cord-254317-n2knqj4z 215 36 group group NN cord-254317-n2knqj4z 215 37 had have VBD cord-254317-n2knqj4z 215 38 a a DT cord-254317-n2knqj4z 215 39 significantly significantly RB cord-254317-n2knqj4z 215 40 higher high JJR cord-254317-n2knqj4z 215 41 peak peak NN cord-254317-n2knqj4z 215 42 titer titer NN cord-254317-n2knqj4z 215 43 ( ( -LRB- cord-254317-n2knqj4z 215 44 13.6 13.6 CD cord-254317-n2knqj4z 215 45 ± ± CD cord-254317-n2knqj4z 215 46 0.7 0.7 CD cord-254317-n2knqj4z 215 47 log log NN cord-254317-n2knqj4z 215 48 10 10 CD cord-254317-n2knqj4z 215 49 copies copy NNS cord-254317-n2knqj4z 215 50 / / SYM cord-254317-n2knqj4z 215 51 mL ml NN cord-254317-n2knqj4z 215 52 ) ) -RRB- cord-254317-n2knqj4z 215 53 ( ( -LRB- cord-254317-n2knqj4z 215 54 Fig Fig NNP cord-254317-n2knqj4z 215 55 . . . cord-254317-n2knqj4z 215 56 1B 1b CD cord-254317-n2knqj4z 215 57 and and CC cord-254317-n2knqj4z 215 58 Table Table NNP cord-254317-n2knqj4z 215 59 2 2 CD cord-254317-n2knqj4z 215 60 ) ) -RRB- cord-254317-n2knqj4z 215 61 at at IN cord-254317-n2knqj4z 215 62 a a DT cord-254317-n2knqj4z 215 63 delayed delay VBN cord-254317-n2knqj4z 215 64 time time NN cord-254317-n2knqj4z 215 65 point point NN cord-254317-n2knqj4z 215 66 ( ( -LRB- cord-254317-n2knqj4z 215 67 1.5 1.5 CD cord-254317-n2knqj4z 215 68 dpi dpi NN cord-254317-n2knqj4z 215 69 ) ) -RRB- cord-254317-n2knqj4z 215 70 . . . cord-254317-n2knqj4z 216 1 In in IN cord-254317-n2knqj4z 216 2 addition addition NN cord-254317-n2knqj4z 216 3 , , , cord-254317-n2knqj4z 216 4 the the DT cord-254317-n2knqj4z 216 5 peak peak NN cord-254317-n2knqj4z 216 6 fecal fecal JJ cord-254317-n2knqj4z 216 7 infectious infectious JJ cord-254317-n2knqj4z 216 8 PEDV PEDV NNP cord-254317-n2knqj4z 216 9 shedding shed VBG cord-254317-n2knqj4z 216 10 titer titer NN cord-254317-n2knqj4z 216 11 of of IN cord-254317-n2knqj4z 216 12 the the DT cord-254317-n2knqj4z 216 13 coinfection coinfection NN cord-254317-n2knqj4z 216 14 group group NN cord-254317-n2knqj4z 216 15 ( ( -LRB- cord-254317-n2knqj4z 216 16 5.8 5.8 CD cord-254317-n2knqj4z 216 17 ± ± CD cord-254317-n2knqj4z 216 18 0.4 0.4 CD cord-254317-n2knqj4z 216 19 log log NN cord-254317-n2knqj4z 216 20 10 10 CD cord-254317-n2knqj4z 216 21 TCID TCID NNP cord-254317-n2knqj4z 216 22 50 50 CD cord-254317-n2knqj4z 216 23 /mL /mL . cord-254317-n2knqj4z 216 24 ) ) -RRB- cord-254317-n2knqj4z 216 25 were be VBD cord-254317-n2knqj4z 216 26 significantly significantly RB cord-254317-n2knqj4z 216 27 higher high JJR cord-254317-n2knqj4z 216 28 than than IN cord-254317-n2knqj4z 216 29 that that DT cord-254317-n2knqj4z 216 30 of of IN cord-254317-n2knqj4z 216 31 the the DT cord-254317-n2knqj4z 216 32 single single JJ cord-254317-n2knqj4z 216 33 infection infection NN cord-254317-n2knqj4z 216 34 groups group NNS cord-254317-n2knqj4z 216 35 ( ( -LRB- cord-254317-n2knqj4z 216 36 4.9 4.9 CD cord-254317-n2knqj4z 216 37 ± ± CD cord-254317-n2knqj4z 216 38 0.1 0.1 CD cord-254317-n2knqj4z 216 39 and and CC cord-254317-n2knqj4z 216 40 1.8 1.8 CD cord-254317-n2knqj4z 216 41 ± ± CD cord-254317-n2knqj4z 216 42 1.8 1.8 CD cord-254317-n2knqj4z 216 43 log log NN cord-254317-n2knqj4z 216 44 10 10 CD cord-254317-n2knqj4z 216 45 TCID TCID NNP cord-254317-n2knqj4z 216 46 50 50 CD cord-254317-n2knqj4z 216 47 /mL /mL NFP cord-254317-n2knqj4z 216 48 of of IN cord-254317-n2knqj4z 216 49 icPC22 icpc22 NN cord-254317-n2knqj4z 216 50 A A NNP cord-254317-n2knqj4z 216 51 and and CC cord-254317-n2knqj4z 216 52 icPC22 icpc22 NN cord-254317-n2knqj4z 216 53 A a DT cord-254317-n2knqj4z 216 54 - - HYPH cord-254317-n2knqj4z 216 55 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 216 56 groups group NNS cord-254317-n2knqj4z 216 57 , , , cord-254317-n2knqj4z 216 58 respectively respectively RB cord-254317-n2knqj4z 216 59 ) ) -RRB- cord-254317-n2knqj4z 216 60 ( ( -LRB- cord-254317-n2knqj4z 216 61 Table table NN cord-254317-n2knqj4z 216 62 2 2 CD cord-254317-n2knqj4z 216 63 ) ) -RRB- cord-254317-n2knqj4z 216 64 . . . cord-254317-n2knqj4z 217 1 Interestingly interestingly RB cord-254317-n2knqj4z 217 2 , , , cord-254317-n2knqj4z 217 3 the the DT cord-254317-n2knqj4z 217 4 peak peak NN cord-254317-n2knqj4z 217 5 S S NNP cord-254317-n2knqj4z 217 6 gene gene NN cord-254317-n2knqj4z 217 7 shedding shed VBG cord-254317-n2knqj4z 217 8 titers titer NNS cord-254317-n2knqj4z 217 9 of of IN cord-254317-n2knqj4z 217 10 icPC22 icpc22 CD cord-254317-n2knqj4z 218 1 A a DT cord-254317-n2knqj4z 218 2 ( ( -LRB- cord-254317-n2knqj4z 218 3 11.4 11.4 CD cord-254317-n2knqj4z 218 4 ± ± CD cord-254317-n2knqj4z 218 5 0.5 0.5 CD cord-254317-n2knqj4z 218 6 log log NN cord-254317-n2knqj4z 218 7 10 10 CD cord-254317-n2knqj4z 218 8 copies copy NNS cord-254317-n2knqj4z 218 9 / / SYM cord-254317-n2knqj4z 218 10 mL ml NN cord-254317-n2knqj4z 218 11 ) ) -RRB- cord-254317-n2knqj4z 218 12 in in IN cord-254317-n2knqj4z 218 13 the the DT cord-254317-n2knqj4z 218 14 coinfection coinfection NN cord-254317-n2knqj4z 218 15 group group NN cord-254317-n2knqj4z 218 16 at at IN cord-254317-n2knqj4z 218 17 1.5 1.5 CD cord-254317-n2knqj4z 218 18 dpi dpi NN cord-254317-n2knqj4z 218 19 was be VBD cord-254317-n2knqj4z 218 20 significantly significantly RB cord-254317-n2knqj4z 218 21 higher high JJR cord-254317-n2knqj4z 218 22 than than IN cord-254317-n2knqj4z 218 23 that that DT cord-254317-n2knqj4z 218 24 of of IN cord-254317-n2knqj4z 218 25 icPC22 icpc22 NN cord-254317-n2knqj4z 219 1 A a DT cord-254317-n2knqj4z 219 2 group group NN cord-254317-n2knqj4z 219 3 ( ( -LRB- cord-254317-n2knqj4z 220 1 10.5 10.5 CD cord-254317-n2knqj4z 220 2 ± ± CD cord-254317-n2knqj4z 220 3 0.5 0.5 CD cord-254317-n2knqj4z 220 4 log log NN cord-254317-n2knqj4z 220 5 10 10 CD cord-254317-n2knqj4z 220 6 copies copy NNS cord-254317-n2knqj4z 220 7 / / SYM cord-254317-n2knqj4z 220 8 mL ml NN cord-254317-n2knqj4z 220 9 ) ) -RRB- cord-254317-n2knqj4z 220 10 at at IN cord-254317-n2knqj4z 220 11 1 1 CD cord-254317-n2knqj4z 220 12 dpi dpi NN cord-254317-n2knqj4z 221 1 ( ( -LRB- cord-254317-n2knqj4z 221 2 Fig Fig NNP cord-254317-n2knqj4z 221 3 . . . cord-254317-n2knqj4z 221 4 1C 1c NN cord-254317-n2knqj4z 221 5 , , , cord-254317-n2knqj4z 221 6 Table Table NNP cord-254317-n2knqj4z 221 7 2 2 CD cord-254317-n2knqj4z 221 8 ) ) -RRB- cord-254317-n2knqj4z 221 9 . . . cord-254317-n2knqj4z 222 1 However however RB cord-254317-n2knqj4z 222 2 , , , cord-254317-n2knqj4z 222 3 the the DT cord-254317-n2knqj4z 222 4 peak peak NN cord-254317-n2knqj4z 222 5 S S NNP cord-254317-n2knqj4z 222 6 gene gene NN cord-254317-n2knqj4z 222 7 shedding shed VBG cord-254317-n2knqj4z 222 8 titers titer NNS cord-254317-n2knqj4z 222 9 ( ( -LRB- cord-254317-n2knqj4z 222 10 5.8 5.8 CD cord-254317-n2knqj4z 222 11 ± ± CD cord-254317-n2knqj4z 222 12 1.2 1.2 CD cord-254317-n2knqj4z 222 13 log log NN cord-254317-n2knqj4z 222 14 10 10 CD cord-254317-n2knqj4z 222 15 copies copy NNS cord-254317-n2knqj4z 222 16 / / SYM cord-254317-n2knqj4z 222 17 mL ml NN cord-254317-n2knqj4z 222 18 ) ) -RRB- cord-254317-n2knqj4z 222 19 of of IN cord-254317-n2knqj4z 222 20 icPC22 icpc22 NN cord-254317-n2knqj4z 223 1 A a LS cord-254317-n2knqj4z 223 2 - - HYPH cord-254317-n2knqj4z 223 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 223 4 in in IN cord-254317-n2knqj4z 223 5 the the DT cord-254317-n2knqj4z 223 6 coinfection coinfection NN cord-254317-n2knqj4z 223 7 group group NN cord-254317-n2knqj4z 223 8 was be VBD cord-254317-n2knqj4z 223 9 significantly significantly RB cord-254317-n2knqj4z 223 10 lower low JJR cord-254317-n2knqj4z 223 11 than than IN cord-254317-n2knqj4z 223 12 that that DT cord-254317-n2knqj4z 223 13 of of IN cord-254317-n2knqj4z 223 14 the the DT cord-254317-n2knqj4z 223 15 icPC22 icPC22 NNP cord-254317-n2knqj4z 223 16 A A NNP cord-254317-n2knqj4z 223 17 - - HYPH cord-254317-n2knqj4z 223 18 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 223 19 group group NN cord-254317-n2knqj4z 223 20 ( ( -LRB- cord-254317-n2knqj4z 223 21 7.6 7.6 CD cord-254317-n2knqj4z 223 22 ± ± CD cord-254317-n2knqj4z 223 23 1.7 1.7 CD cord-254317-n2knqj4z 223 24 log log NN cord-254317-n2knqj4z 223 25 10 10 CD cord-254317-n2knqj4z 223 26 copies copy NNS cord-254317-n2knqj4z 223 27 / / SYM cord-254317-n2knqj4z 223 28 mL ml NN cord-254317-n2knqj4z 223 29 ) ) -RRB- cord-254317-n2knqj4z 223 30 ( ( -LRB- cord-254317-n2knqj4z 223 31 Fig fig NN cord-254317-n2knqj4z 223 32 . . . cord-254317-n2knqj4z 224 1 1C 1C NNP cord-254317-n2knqj4z 224 2 , , , cord-254317-n2knqj4z 224 3 Table Table NNP cord-254317-n2knqj4z 224 4 2 2 CD cord-254317-n2knqj4z 224 5 ) ) -RRB- cord-254317-n2knqj4z 224 6 . . . cord-254317-n2knqj4z 225 1 In in IN cord-254317-n2knqj4z 225 2 the the DT cord-254317-n2knqj4z 225 3 second second JJ cord-254317-n2knqj4z 225 4 passage passage NN cord-254317-n2knqj4z 225 5 of of IN cord-254317-n2knqj4z 225 6 coinfection coinfection NN cord-254317-n2knqj4z 225 7 , , , cord-254317-n2knqj4z 225 8 only only RB cord-254317-n2knqj4z 225 9 icPC22 icpc22 NN cord-254317-n2knqj4z 225 10 A a NN cord-254317-n2knqj4z 225 11 but but CC cord-254317-n2knqj4z 225 12 not not RB cord-254317-n2knqj4z 225 13 icPC22 icpc22 NN cord-254317-n2knqj4z 225 14 A A NNP cord-254317-n2knqj4z 225 15 - - HYPH cord-254317-n2knqj4z 225 16 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 225 17 S s NN cord-254317-n2knqj4z 225 18 gene gene NN cord-254317-n2knqj4z 225 19 was be VBD cord-254317-n2knqj4z 225 20 detected detect VBN cord-254317-n2knqj4z 225 21 in in IN cord-254317-n2knqj4z 225 22 the the DT cord-254317-n2knqj4z 225 23 large large JJ cord-254317-n2knqj4z 225 24 intestinal intestinal JJ cord-254317-n2knqj4z 225 25 contents content NNS cord-254317-n2knqj4z 225 26 ( ( -LRB- cord-254317-n2knqj4z 225 27 LIC LIC NNP cord-254317-n2knqj4z 225 28 ) ) -RRB- cord-254317-n2knqj4z 225 29 of of IN cord-254317-n2knqj4z 225 30 the the DT cord-254317-n2knqj4z 225 31 piglet piglet NN cord-254317-n2knqj4z 225 32 , , , cord-254317-n2knqj4z 225 33 which which WDT cord-254317-n2knqj4z 225 34 was be VBD cord-254317-n2knqj4z 225 35 orally orally RB cord-254317-n2knqj4z 225 36 inoculated inoculate VBN cord-254317-n2knqj4z 225 37 with with IN cord-254317-n2knqj4z 225 38 the the DT cord-254317-n2knqj4z 225 39 SIC sic NN cord-254317-n2knqj4z 225 40 ( ( -LRB- cord-254317-n2knqj4z 225 41 sample sample NN cord-254317-n2knqj4z 225 42 # # NN cord-254317-n2knqj4z 225 43 PE1158 pe1158 NN cord-254317-n2knqj4z 225 44 ) ) -RRB- cord-254317-n2knqj4z 225 45 of of IN cord-254317-n2knqj4z 225 46 one one CD cord-254317-n2knqj4z 225 47 pig pig NN cord-254317-n2knqj4z 225 48 in in IN cord-254317-n2knqj4z 225 49 the the DT cord-254317-n2knqj4z 225 50 coinfection coinfection NN cord-254317-n2knqj4z 225 51 group group NN cord-254317-n2knqj4z 225 52 and and CC cord-254317-n2knqj4z 225 53 was be VBD cord-254317-n2knqj4z 225 54 positive positive JJ cord-254317-n2knqj4z 225 55 for for IN cord-254317-n2knqj4z 225 56 both both DT cord-254317-n2knqj4z 225 57 viruses virus NNS cord-254317-n2knqj4z 225 58 . . . cord-254317-n2knqj4z 226 1 The the DT cord-254317-n2knqj4z 226 2 LIC LIC NNP cord-254317-n2knqj4z 226 3 had have VBD cord-254317-n2knqj4z 226 4 a a DT cord-254317-n2knqj4z 226 5 virus virus NN cord-254317-n2knqj4z 226 6 titer titer NN cord-254317-n2knqj4z 226 7 of of IN cord-254317-n2knqj4z 226 8 8.8 8.8 CD cord-254317-n2knqj4z 226 9 log log NN cord-254317-n2knqj4z 226 10 10 10 CD cord-254317-n2knqj4z 226 11 TCID TCID NNP cord-254317-n2knqj4z 226 12 50 50 CD cord-254317-n2knqj4z 226 13 /mL /mL : cord-254317-n2knqj4z 226 14 for for IN cord-254317-n2knqj4z 226 15 infectious infectious JJ cord-254317-n2knqj4z 226 16 PEDV PEDV NNP cord-254317-n2knqj4z 226 17 , , , cord-254317-n2knqj4z 226 18 12.3 12.3 CD cord-254317-n2knqj4z 226 19 log log NN cord-254317-n2knqj4z 226 20 10 10 CD cord-254317-n2knqj4z 226 21 S s NN cord-254317-n2knqj4z 226 22 gene gene NN cord-254317-n2knqj4z 226 23 copies copy NNS cord-254317-n2knqj4z 226 24 / / SYM cord-254317-n2knqj4z 226 25 mL ml NN cord-254317-n2knqj4z 226 26 and and CC cord-254317-n2knqj4z 226 27 14.6 14.6 CD cord-254317-n2knqj4z 226 28 log log NN cord-254317-n2knqj4z 226 29 10 10 CD cord-254317-n2knqj4z 226 30 N n NN cord-254317-n2knqj4z 227 1 gene gene NNP cord-254317-n2knqj4z 227 2 copies copy NNS cord-254317-n2knqj4z 227 3 / / SYM cord-254317-n2knqj4z 227 4 mL ml XX cord-254317-n2knqj4z 227 5 for for IN cord-254317-n2knqj4z 227 6 icPC22A. icPC22A. NNP cord-254317-n2knqj4z 227 7 Histopathological Histopathological NNP cord-254317-n2knqj4z 227 8 examination examination NN cord-254317-n2knqj4z 227 9 was be VBD cord-254317-n2knqj4z 227 10 performed perform VBN cord-254317-n2knqj4z 227 11 and and CC cord-254317-n2knqj4z 227 12 villous villous NNP cord-254317-n2knqj4z 227 13 atrophy atrophy NN cord-254317-n2knqj4z 227 14 was be VBD cord-254317-n2knqj4z 227 15 observed observe VBN cord-254317-n2knqj4z 227 16 in in IN cord-254317-n2knqj4z 227 17 the the DT cord-254317-n2knqj4z 227 18 jejunum jejunum NN cord-254317-n2knqj4z 227 19 and and CC cord-254317-n2knqj4z 227 20 ileum ileum NN cord-254317-n2knqj4z 227 21 of of IN cord-254317-n2knqj4z 227 22 piglets piglet NNS cord-254317-n2knqj4z 227 23 in in IN cord-254317-n2knqj4z 227 24 all all DT cord-254317-n2knqj4z 227 25 PEDV PEDV NNP cord-254317-n2knqj4z 227 26 - - HYPH cord-254317-n2knqj4z 227 27 inoculated inoculate VBN cord-254317-n2knqj4z 227 28 groups group NNS cord-254317-n2knqj4z 228 1 ( ( -LRB- cord-254317-n2knqj4z 228 2 Fig Fig NNP cord-254317-n2knqj4z 228 3 . . . cord-254317-n2knqj4z 228 4 2A 2a CD cord-254317-n2knqj4z 228 5 and and CC cord-254317-n2knqj4z 228 6 B B NNP cord-254317-n2knqj4z 228 7 ) ) -RRB- cord-254317-n2knqj4z 228 8 . . . cord-254317-n2knqj4z 229 1 The the DT cord-254317-n2knqj4z 229 2 small small JJ cord-254317-n2knqj4z 229 3 intestinal intestinal JJ cord-254317-n2knqj4z 229 4 villi villi NN cord-254317-n2knqj4z 229 5 in in IN cord-254317-n2knqj4z 229 6 the the DT cord-254317-n2knqj4z 229 7 icPC22A icPC22A NNP cord-254317-n2knqj4z 229 8 - - HYPH cord-254317-n2knqj4z 229 9 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 229 10 group group NN cord-254317-n2knqj4z 229 11 had have VBD cord-254317-n2knqj4z 229 12 a a DT cord-254317-n2knqj4z 229 13 milder mild JJR cord-254317-n2knqj4z 229 14 villous villous JJ cord-254317-n2knqj4z 229 15 atrophy atrophy NN cord-254317-n2knqj4z 229 16 than than IN cord-254317-n2knqj4z 229 17 those those DT cord-254317-n2knqj4z 229 18 in in IN cord-254317-n2knqj4z 229 19 the the DT cord-254317-n2knqj4z 229 20 icPC22A icPC22A NNP cord-254317-n2knqj4z 229 21 and and CC cord-254317-n2knqj4z 229 22 coinfection coinfection NN cord-254317-n2knqj4z 229 23 groups group NNS cord-254317-n2knqj4z 229 24 . . . cord-254317-n2knqj4z 230 1 The the DT cord-254317-n2knqj4z 230 2 VH VH NNP cord-254317-n2knqj4z 230 3 / / SYM cord-254317-n2knqj4z 230 4 CD cd NN cord-254317-n2knqj4z 230 5 ratios ratio NNS cord-254317-n2knqj4z 230 6 of of IN cord-254317-n2knqj4z 230 7 jejunum jejunum NNS cord-254317-n2knqj4z 230 8 and and CC cord-254317-n2knqj4z 230 9 ileum ileum NN cord-254317-n2knqj4z 230 10 of of IN cord-254317-n2knqj4z 230 11 all all PDT cord-254317-n2knqj4z 230 12 the the DT cord-254317-n2knqj4z 230 13 PEDV PEDV NNP cord-254317-n2knqj4z 230 14 - - HYPH cord-254317-n2knqj4z 230 15 inoculated inoculate VBN cord-254317-n2knqj4z 230 16 groups group NNS cord-254317-n2knqj4z 230 17 were be VBD cord-254317-n2knqj4z 230 18 significantly significantly RB cord-254317-n2knqj4z 230 19 lower low JJR cord-254317-n2knqj4z 230 20 than than IN cord-254317-n2knqj4z 230 21 those those DT cord-254317-n2knqj4z 230 22 of of IN cord-254317-n2knqj4z 230 23 the the DT cord-254317-n2knqj4z 230 24 mock mock JJ cord-254317-n2knqj4z 230 25 group group NN cord-254317-n2knqj4z 230 26 ( ( -LRB- cord-254317-n2knqj4z 230 27 Fig Fig NNP cord-254317-n2knqj4z 230 28 . . . cord-254317-n2knqj4z 230 29 2B 2b CD cord-254317-n2knqj4z 230 30 ) ) -RRB- cord-254317-n2knqj4z 230 31 . . . cord-254317-n2knqj4z 231 1 The the DT cord-254317-n2knqj4z 231 2 ratios ratio NNS cord-254317-n2knqj4z 231 3 of of IN cord-254317-n2knqj4z 231 4 the the DT cord-254317-n2knqj4z 231 5 icPC22 icPC22 NNP cord-254317-n2knqj4z 231 6 A A NNP cord-254317-n2knqj4z 231 7 and and CC cord-254317-n2knqj4z 231 8 coinfection coinfection NN cord-254317-n2knqj4z 231 9 groups group NNS cord-254317-n2knqj4z 231 10 were be VBD cord-254317-n2knqj4z 231 11 similar similar JJ cord-254317-n2knqj4z 231 12 and and CC cord-254317-n2knqj4z 231 13 were be VBD cord-254317-n2knqj4z 231 14 significantly significantly RB cord-254317-n2knqj4z 231 15 lower low JJR cord-254317-n2knqj4z 231 16 than than IN cord-254317-n2knqj4z 231 17 that that DT cord-254317-n2knqj4z 231 18 of of IN cord-254317-n2knqj4z 231 19 the the DT cord-254317-n2knqj4z 231 20 icPC22 icPC22 NNP cord-254317-n2knqj4z 231 21 A A NNP cord-254317-n2knqj4z 231 22 - - HYPH cord-254317-n2knqj4z 231 23 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 231 24 group group NN cord-254317-n2knqj4z 231 25 . . . cord-254317-n2knqj4z 232 1 IHC IHC NNP cord-254317-n2knqj4z 232 2 staining staining NN cord-254317-n2knqj4z 232 3 showed show VBD cord-254317-n2knqj4z 232 4 that that IN cord-254317-n2knqj4z 232 5 no no DT cord-254317-n2knqj4z 232 6 PEDV PEDV NNP cord-254317-n2knqj4z 232 7 - - HYPH cord-254317-n2knqj4z 232 8 positive positive JJ cord-254317-n2knqj4z 232 9 intestinal intestinal JJ cord-254317-n2knqj4z 232 10 epithelial epithelial JJ cord-254317-n2knqj4z 232 11 cells cell NNS cord-254317-n2knqj4z 232 12 were be VBD cord-254317-n2knqj4z 232 13 observed observe VBN cord-254317-n2knqj4z 232 14 in in IN cord-254317-n2knqj4z 232 15 all all DT cord-254317-n2knqj4z 232 16 PEDV PEDV NNP cord-254317-n2knqj4z 232 17 - - HYPH cord-254317-n2knqj4z 232 18 inoculated inoculate VBN cord-254317-n2knqj4z 232 19 pigs pig NNS cord-254317-n2knqj4z 232 20 Fig Fig NNP cord-254317-n2knqj4z 232 21 . . . cord-254317-n2knqj4z 233 1 1 1 LS cord-254317-n2knqj4z 233 2 . . . cord-254317-n2knqj4z 234 1 Evaluation evaluation NN cord-254317-n2knqj4z 234 2 of of IN cord-254317-n2knqj4z 234 3 the the DT cord-254317-n2knqj4z 234 4 replication replication NN cord-254317-n2knqj4z 234 5 of of IN cord-254317-n2knqj4z 234 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 234 7 and and CC cord-254317-n2knqj4z 234 8 icPC22A icPC22A NNP cord-254317-n2knqj4z 234 9 - - HYPH cord-254317-n2knqj4z 234 10 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 234 11 in in IN cord-254317-n2knqj4z 234 12 Gn Gn NNP cord-254317-n2knqj4z 234 13 pigs pig NNS cord-254317-n2knqj4z 234 14 infected infect VBN cord-254317-n2knqj4z 234 15 with with IN cord-254317-n2knqj4z 234 16 individual individual NN cord-254317-n2knqj4z 234 17 or or CC cord-254317-n2knqj4z 234 18 both both DT cord-254317-n2knqj4z 234 19 viruses virus NNS cord-254317-n2knqj4z 234 20 . . . cord-254317-n2knqj4z 235 1 ( ( -LRB- cord-254317-n2knqj4z 235 2 A a DT cord-254317-n2knqj4z 235 3 ) ) -RRB- cord-254317-n2knqj4z 235 4 Fecal fecal JJ cord-254317-n2knqj4z 235 5 consistency consistency NN cord-254317-n2knqj4z 235 6 scores score NNS cord-254317-n2knqj4z 235 7 of of IN cord-254317-n2knqj4z 235 8 individual individual JJ cord-254317-n2knqj4z 235 9 Gn Gn NNP cord-254317-n2knqj4z 235 10 piglets piglet NNS cord-254317-n2knqj4z 235 11 and and CC cord-254317-n2knqj4z 235 12 the the DT cord-254317-n2knqj4z 235 13 mean mean NN cord-254317-n2knqj4z 235 14 of of IN cord-254317-n2knqj4z 235 15 each each DT cord-254317-n2knqj4z 235 16 group group NN cord-254317-n2knqj4z 235 17 were be VBD cord-254317-n2knqj4z 235 18 shown show VBN cord-254317-n2knqj4z 235 19 . . . cord-254317-n2knqj4z 236 1 The the DT cord-254317-n2knqj4z 236 2 scores score NNS cord-254317-n2knqj4z 236 3 were be VBD cord-254317-n2knqj4z 236 4 named name VBN cord-254317-n2knqj4z 236 5 as as IN cord-254317-n2knqj4z 236 6 follows follow VBZ cord-254317-n2knqj4z 236 7 : : : cord-254317-n2knqj4z 236 8 0 0 NFP cord-254317-n2knqj4z 236 9 , , , cord-254317-n2knqj4z 236 10 solid solid JJ cord-254317-n2knqj4z 236 11 ( ( -LRB- cord-254317-n2knqj4z 236 12 normal normal JJ cord-254317-n2knqj4z 236 13 ) ) -RRB- cord-254317-n2knqj4z 236 14 ; ; : cord-254317-n2knqj4z 236 15 1 1 CD cord-254317-n2knqj4z 236 16 , , , cord-254317-n2knqj4z 236 17 pasty pasty JJ cord-254317-n2knqj4z 236 18 ( ( -LRB- cord-254317-n2knqj4z 236 19 normal normal JJ cord-254317-n2knqj4z 236 20 ) ) -RRB- cord-254317-n2knqj4z 236 21 ; ; : cord-254317-n2knqj4z 236 22 2 2 CD cord-254317-n2knqj4z 236 23 , , , cord-254317-n2knqj4z 236 24 semiliquid semiliquid NNP cord-254317-n2knqj4z 236 25 ( ( -LRB- cord-254317-n2knqj4z 236 26 mild mild JJ cord-254317-n2knqj4z 236 27 diarrhea diarrhea NN cord-254317-n2knqj4z 236 28 ) ) -RRB- cord-254317-n2knqj4z 236 29 ; ; : cord-254317-n2knqj4z 236 30 and and CC cord-254317-n2knqj4z 236 31 3 3 CD cord-254317-n2knqj4z 236 32 , , , cord-254317-n2knqj4z 236 33 liquid liquid JJ cord-254317-n2knqj4z 236 34 ( ( -LRB- cord-254317-n2knqj4z 236 35 severe severe JJ cord-254317-n2knqj4z 236 36 diarrhea diarrhea NN cord-254317-n2knqj4z 236 37 ) ) -RRB- cord-254317-n2knqj4z 236 38 . . . cord-254317-n2knqj4z 237 1 Two two CD cord-254317-n2knqj4z 237 2 piglets piglet NNS cord-254317-n2knqj4z 237 3 from from IN cord-254317-n2knqj4z 237 4 icPC22A icPC22A NNP cord-254317-n2knqj4z 237 5 , , , cord-254317-n2knqj4z 237 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 237 7 - - HYPH cord-254317-n2knqj4z 237 8 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 237 9 and and CC cord-254317-n2knqj4z 237 10 coinfection coinfection NN cord-254317-n2knqj4z 237 11 groups group NNS cord-254317-n2knqj4z 237 12 , , , cord-254317-n2knqj4z 237 13 and and CC cord-254317-n2knqj4z 237 14 one one CD cord-254317-n2knqj4z 237 15 pig pig NN cord-254317-n2knqj4z 237 16 from from IN cord-254317-n2knqj4z 237 17 mock mock JJ cord-254317-n2knqj4z 237 18 group group NN cord-254317-n2knqj4z 237 19 were be VBD cord-254317-n2knqj4z 237 20 euthanized euthanize VBN cord-254317-n2knqj4z 237 21 at at IN cord-254317-n2knqj4z 237 22 12 12 CD cord-254317-n2knqj4z 237 23 hpi hpi NNS cord-254317-n2knqj4z 237 24 and and CC cord-254317-n2knqj4z 237 25 2 2 CD cord-254317-n2knqj4z 237 26 - - SYM cord-254317-n2knqj4z 237 27 3 3 CD cord-254317-n2knqj4z 237 28 dpi dpi NN cord-254317-n2knqj4z 237 29 , , , cord-254317-n2knqj4z 237 30 respectively respectively RB cord-254317-n2knqj4z 237 31 , , , cord-254317-n2knqj4z 237 32 for for IN cord-254317-n2knqj4z 237 33 histopathological histopathological JJ cord-254317-n2knqj4z 237 34 examination examination NN cord-254317-n2knqj4z 237 35 . . . cord-254317-n2knqj4z 238 1 ( ( -LRB- cord-254317-n2knqj4z 238 2 B b NN cord-254317-n2knqj4z 238 3 ) ) -RRB- cord-254317-n2knqj4z 239 1 Fecal Fecal NNP cord-254317-n2knqj4z 239 2 PEDV PEDV NNP cord-254317-n2knqj4z 239 3 N N NNP cord-254317-n2knqj4z 240 1 gene gene NNP cord-254317-n2knqj4z 240 2 RNA RNA NNP cord-254317-n2knqj4z 240 3 shedding shed VBG cord-254317-n2knqj4z 240 4 titers titer NNS cord-254317-n2knqj4z 240 5 ( ( -LRB- cord-254317-n2knqj4z 240 6 for for IN cord-254317-n2knqj4z 240 7 both both DT cord-254317-n2knqj4z 240 8 icPC22A icPC22A NNP cord-254317-n2knqj4z 240 9 and and CC cord-254317-n2knqj4z 240 10 icPC22A icPC22A NNP cord-254317-n2knqj4z 240 11 - - HYPH cord-254317-n2knqj4z 240 12 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 240 13 ) ) -RRB- cord-254317-n2knqj4z 240 14 of of IN cord-254317-n2knqj4z 240 15 each each DT cord-254317-n2knqj4z 240 16 group group NN cord-254317-n2knqj4z 240 17 . . . cord-254317-n2knqj4z 241 1 Data datum NNS cord-254317-n2knqj4z 241 2 are be VBP cord-254317-n2knqj4z 241 3 shown show VBN cord-254317-n2knqj4z 241 4 as as IN cord-254317-n2knqj4z 241 5 mean mean JJ cord-254317-n2knqj4z 241 6 ( ( -LRB- cord-254317-n2knqj4z 241 7 M M NNP cord-254317-n2knqj4z 241 8 ) ) -RRB- cord-254317-n2knqj4z 241 9 ± ± CD cord-254317-n2knqj4z 241 10 standard standard JJ cord-254317-n2knqj4z 241 11 deviations deviation NNS cord-254317-n2knqj4z 241 12 ( ( -LRB- cord-254317-n2knqj4z 241 13 SD sd NN cord-254317-n2knqj4z 241 14 ) ) -RRB- cord-254317-n2knqj4z 241 15 of of IN cord-254317-n2knqj4z 241 16 pigs pig NNS cord-254317-n2knqj4z 241 17 in in IN cord-254317-n2knqj4z 241 18 each each DT cord-254317-n2knqj4z 241 19 group group NN cord-254317-n2knqj4z 241 20 . . . cord-254317-n2knqj4z 242 1 ( ( -LRB- cord-254317-n2knqj4z 242 2 C C NNP cord-254317-n2knqj4z 242 3 ) ) -RRB- cord-254317-n2knqj4z 242 4 Fecal Fecal NNP cord-254317-n2knqj4z 242 5 PEDV PEDV NNP cord-254317-n2knqj4z 242 6 S S NNP cord-254317-n2knqj4z 242 7 gene gene NN cord-254317-n2knqj4z 242 8 RNA RNA NNP cord-254317-n2knqj4z 242 9 shedding shed VBG cord-254317-n2knqj4z 242 10 titles title NNS cord-254317-n2knqj4z 242 11 of of IN cord-254317-n2knqj4z 242 12 each each DT cord-254317-n2knqj4z 242 13 virus virus NN cord-254317-n2knqj4z 242 14 . . . cord-254317-n2knqj4z 243 1 Data datum NNS cord-254317-n2knqj4z 243 2 are be VBP cord-254317-n2knqj4z 243 3 shown show VBN cord-254317-n2knqj4z 243 4 as as IN cord-254317-n2knqj4z 243 5 M M NNP cord-254317-n2knqj4z 243 6 ± ± NNP cord-254317-n2knqj4z 243 7 SD SD NNP cord-254317-n2knqj4z 243 8 . . . cord-254317-n2knqj4z 244 1 at at IN cord-254317-n2knqj4z 244 2 0.5 0.5 CD cord-254317-n2knqj4z 244 3 dpi dpi NN cord-254317-n2knqj4z 244 4 ( ( -LRB- cord-254317-n2knqj4z 244 5 data datum NNS cord-254317-n2knqj4z 244 6 not not RB cord-254317-n2knqj4z 244 7 shown show VBN cord-254317-n2knqj4z 244 8 ) ) -RRB- cord-254317-n2knqj4z 244 9 . . . cord-254317-n2knqj4z 245 1 At at IN cord-254317-n2knqj4z 245 2 2 2 CD cord-254317-n2knqj4z 245 3 - - SYM cord-254317-n2knqj4z 245 4 3 3 CD cord-254317-n2knqj4z 245 5 dpi dpi NN cord-254317-n2knqj4z 245 6 , , , cord-254317-n2knqj4z 245 7 a a DT cord-254317-n2knqj4z 245 8 few few JJ cord-254317-n2knqj4z 245 9 PEDV PEDV NNP cord-254317-n2knqj4z 245 10 N n CD cord-254317-n2knqj4z 245 11 antigens antigen NNS cord-254317-n2knqj4z 245 12 were be VBD cord-254317-n2knqj4z 245 13 observed observe VBN cord-254317-n2knqj4z 245 14 in in IN cord-254317-n2knqj4z 245 15 the the DT cord-254317-n2knqj4z 245 16 small small JJ cord-254317-n2knqj4z 245 17 intestine intestine NN cord-254317-n2knqj4z 245 18 of of IN cord-254317-n2knqj4z 245 19 the the DT cord-254317-n2knqj4z 245 20 icPC22A icPC22A NNP cord-254317-n2knqj4z 245 21 - - HYPH cord-254317-n2knqj4z 245 22 S1Δ197-infected s1δ197-infecte VBN cord-254317-n2knqj4z 245 23 piglets piglet NNS cord-254317-n2knqj4z 245 24 , , , cord-254317-n2knqj4z 245 25 while while IN cord-254317-n2knqj4z 245 26 extensive extensive JJ cord-254317-n2knqj4z 245 27 antigens antigen NNS cord-254317-n2knqj4z 245 28 were be VBD cord-254317-n2knqj4z 245 29 stained stain VBN cord-254317-n2knqj4z 245 30 in in IN cord-254317-n2knqj4z 245 31 those those DT cord-254317-n2knqj4z 245 32 of of IN cord-254317-n2knqj4z 245 33 the the DT cord-254317-n2knqj4z 245 34 icPC22A icPC22A NNP cord-254317-n2knqj4z 245 35 and and CC cord-254317-n2knqj4z 245 36 coinfection coinfection NN cord-254317-n2knqj4z 245 37 piglets piglet NNS cord-254317-n2knqj4z 245 38 ( ( -LRB- cord-254317-n2knqj4z 245 39 Fig Fig NNP cord-254317-n2knqj4z 245 40 . . . cord-254317-n2knqj4z 245 41 2A 2a CD cord-254317-n2knqj4z 245 42 ) ) -RRB- cord-254317-n2knqj4z 245 43 . . . cord-254317-n2knqj4z 246 1 By by IN cord-254317-n2knqj4z 246 2 IF if IN cord-254317-n2knqj4z 246 3 staining stain VBG cord-254317-n2knqj4z 246 4 for for IN cord-254317-n2knqj4z 246 5 the the DT cord-254317-n2knqj4z 246 6 PEDV PEDV NNP cord-254317-n2knqj4z 246 7 S1 S1 NNP cord-254317-n2knqj4z 246 8 proteins protein NNS cord-254317-n2knqj4z 246 9 , , , cord-254317-n2knqj4z 246 10 a a DT cord-254317-n2knqj4z 246 11 few few JJ cord-254317-n2knqj4z 246 12 PEDV PEDV NNP cord-254317-n2knqj4z 246 13 antigens antigen NNS cord-254317-n2knqj4z 246 14 were be VBD cord-254317-n2knqj4z 246 15 observed observe VBN cord-254317-n2knqj4z 246 16 in in IN cord-254317-n2knqj4z 246 17 the the DT cord-254317-n2knqj4z 246 18 jejunum jejunum NNS cord-254317-n2knqj4z 246 19 of of IN cord-254317-n2knqj4z 246 20 the the DT cord-254317-n2knqj4z 246 21 icPC22A icPC22A NNP cord-254317-n2knqj4z 246 22 - - HYPH cord-254317-n2knqj4z 246 23 S1Δ197-inoculated s1δ197-inoculate VBN cord-254317-n2knqj4z 246 24 piglets piglet NNS cord-254317-n2knqj4z 246 25 ( ( -LRB- cord-254317-n2knqj4z 246 26 green green JJ cord-254317-n2knqj4z 246 27 alone alone RB cord-254317-n2knqj4z 246 28 , , , cord-254317-n2knqj4z 246 29 positive positive JJ cord-254317-n2knqj4z 246 30 for for IN cord-254317-n2knqj4z 246 31 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 246 32 only only RB cord-254317-n2knqj4z 246 33 ) ) -RRB- cord-254317-n2knqj4z 246 34 , , , cord-254317-n2knqj4z 246 35 while while IN cord-254317-n2knqj4z 246 36 many many JJ cord-254317-n2knqj4z 246 37 antigens antigen NNS cord-254317-n2knqj4z 246 38 were be VBD cord-254317-n2knqj4z 246 39 observed observe VBN cord-254317-n2knqj4z 246 40 in in IN cord-254317-n2knqj4z 246 41 those those DT cord-254317-n2knqj4z 246 42 of of IN cord-254317-n2knqj4z 246 43 the the DT cord-254317-n2knqj4z 246 44 icPC22 icPC22 NNP cord-254317-n2knqj4z 246 45 A A NNP cord-254317-n2knqj4z 246 46 - - HYPH cord-254317-n2knqj4z 246 47 inoculated inoculate VBN cord-254317-n2knqj4z 246 48 piglets piglet NNS cord-254317-n2knqj4z 246 49 [ [ -LRB- cord-254317-n2knqj4z 246 50 yellow yellow JJ cord-254317-n2knqj4z 246 51 , , , cord-254317-n2knqj4z 246 52 representing represent VBG cord-254317-n2knqj4z 246 53 positive positive JJ cord-254317-n2knqj4z 246 54 for for IN cord-254317-n2knqj4z 246 55 both both DT cord-254317-n2knqj4z 246 56 S1Δ197 s1δ197 JJ cord-254317-n2knqj4z 246 57 ( ( -LRB- cord-254317-n2knqj4z 246 58 green green JJ cord-254317-n2knqj4z 246 59 ) ) -RRB- cord-254317-n2knqj4z 246 60 and and CC cord-254317-n2knqj4z 247 1 S1 S1 NNP cord-254317-n2knqj4z 247 2 ° ° NNP cord-254317-n2knqj4z 247 3 d d NNP cord-254317-n2knqj4z 247 4 omain omain NNP cord-254317-n2knqj4z 247 5 ( ( -LRB- cord-254317-n2knqj4z 247 6 red red NNP cord-254317-n2knqj4z 247 7 ) ) -RRB- cord-254317-n2knqj4z 247 8 ] ] -RRB- cord-254317-n2knqj4z 247 9 and and CC cord-254317-n2knqj4z 247 10 the the DT cord-254317-n2knqj4z 247 11 coinfection coinfection NN cord-254317-n2knqj4z 247 12 piglets piglet NNS cord-254317-n2knqj4z 247 13 ( ( -LRB- cord-254317-n2knqj4z 247 14 yellow yellow JJ cord-254317-n2knqj4z 247 15 ) ) -RRB- cord-254317-n2knqj4z 248 1 ( ( -LRB- cord-254317-n2knqj4z 248 2 Fig Fig NNP cord-254317-n2knqj4z 248 3 . . . cord-254317-n2knqj4z 248 4 2C 2C NNP cord-254317-n2knqj4z 248 5 ) ) -RRB- cord-254317-n2knqj4z 248 6 . . . cord-254317-n2knqj4z 249 1 3.2 3.2 CD cord-254317-n2knqj4z 249 2 . . . cord-254317-n2knqj4z 249 3 icPC22A icPC22A '' cord-254317-n2knqj4z 249 4 alone alone RB cord-254317-n2knqj4z 249 5 , , , cord-254317-n2knqj4z 249 6 but but CC cord-254317-n2knqj4z 249 7 not not RB cord-254317-n2knqj4z 249 8 icPC22A icPC22A NNP cord-254317-n2knqj4z 249 9 - - HYPH cord-254317-n2knqj4z 249 10 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 249 11 alone alone RB cord-254317-n2knqj4z 249 12 was be VBD cord-254317-n2knqj4z 249 13 isolated isolate VBN cord-254317-n2knqj4z 249 14 from from IN cord-254317-n2knqj4z 249 15 the the DT cord-254317-n2knqj4z 249 16 SIC sic NN cord-254317-n2knqj4z 249 17 of of IN cord-254317-n2knqj4z 249 18 one one CD cord-254317-n2knqj4z 249 19 of of IN cord-254317-n2knqj4z 249 20 the the DT cord-254317-n2knqj4z 249 21 pigs pig NNS cord-254317-n2knqj4z 249 22 infected infect VBN cord-254317-n2knqj4z 249 23 with with IN cord-254317-n2knqj4z 249 24 the the DT cord-254317-n2knqj4z 249 25 two two CD cord-254317-n2knqj4z 249 26 viruses virus NNS cord-254317-n2knqj4z 249 27 simultaneously simultaneously RB cord-254317-n2knqj4z 249 28 The the DT cord-254317-n2knqj4z 249 29 SIC sic NN cord-254317-n2knqj4z 249 30 of of IN cord-254317-n2knqj4z 249 31 the the DT cord-254317-n2knqj4z 249 32 one one CD cord-254317-n2knqj4z 249 33 piglet piglet NN cord-254317-n2knqj4z 249 34 in in IN cord-254317-n2knqj4z 249 35 the the DT cord-254317-n2knqj4z 249 36 coinfection coinfection NN cord-254317-n2knqj4z 249 37 group group NN cord-254317-n2knqj4z 249 38 , , , cord-254317-n2knqj4z 249 39 which which WDT cord-254317-n2knqj4z 249 40 was be VBD cord-254317-n2knqj4z 249 41 positive positive JJ cord-254317-n2knqj4z 249 42 for for IN cord-254317-n2knqj4z 249 43 both both DT cord-254317-n2knqj4z 249 44 viruses virus NNS cord-254317-n2knqj4z 249 45 by by IN cord-254317-n2knqj4z 249 46 the the DT cord-254317-n2knqj4z 249 47 duplex duplex JJ cord-254317-n2knqj4z 249 48 RT RT NNP cord-254317-n2knqj4z 249 49 - - HYPH cord-254317-n2knqj4z 249 50 qPCR qPCR NNP cord-254317-n2knqj4z 249 51 were be VBD cord-254317-n2knqj4z 249 52 used use VBN cord-254317-n2knqj4z 249 53 for for IN cord-254317-n2knqj4z 249 54 virus virus NN cord-254317-n2knqj4z 249 55 isolation isolation NN cord-254317-n2knqj4z 249 56 in in IN cord-254317-n2knqj4z 249 57 Vero Vero NNP cord-254317-n2knqj4z 249 58 cells cell NNS cord-254317-n2knqj4z 249 59 using use VBG cord-254317-n2knqj4z 249 60 plague plague NN cord-254317-n2knqj4z 249 61 assays assay NNS cord-254317-n2knqj4z 249 62 . . . cord-254317-n2knqj4z 250 1 We -PRON- PRP cord-254317-n2knqj4z 250 2 picked pick VBD cord-254317-n2knqj4z 250 3 up up RP cord-254317-n2knqj4z 250 4 72 72 CD cord-254317-n2knqj4z 250 5 plagues plague NNS cord-254317-n2knqj4z 250 6 and and CC cord-254317-n2knqj4z 250 7 found find VBD cord-254317-n2knqj4z 250 8 that that IN cord-254317-n2knqj4z 250 9 55 55 CD cord-254317-n2knqj4z 250 10 plagues plague NNS cord-254317-n2knqj4z 250 11 were be VBD cord-254317-n2knqj4z 250 12 positive positive JJ cord-254317-n2knqj4z 250 13 for for IN cord-254317-n2knqj4z 250 14 icPC22A icPC22A NNP cord-254317-n2knqj4z 250 15 and and CC cord-254317-n2knqj4z 250 16 17 17 CD cord-254317-n2knqj4z 250 17 plagues plague NNS cord-254317-n2knqj4z 250 18 were be VBD cord-254317-n2knqj4z 250 19 positive positive JJ cord-254317-n2knqj4z 250 20 for for IN cord-254317-n2knqj4z 250 21 both both DT cord-254317-n2knqj4z 250 22 viruses virus NNS cord-254317-n2knqj4z 250 23 by by IN cord-254317-n2knqj4z 250 24 the the DT cord-254317-n2knqj4z 250 25 duplex duplex JJ cord-254317-n2knqj4z 250 26 RT rt NN cord-254317-n2knqj4z 250 27 - - HYPH cord-254317-n2knqj4z 250 28 qPCR qPCR NNP cord-254317-n2knqj4z 250 29 . . . cord-254317-n2knqj4z 251 1 No no DT cord-254317-n2knqj4z 251 2 plagues plague NNS cord-254317-n2knqj4z 251 3 were be VBD cord-254317-n2knqj4z 251 4 positive positive JJ cord-254317-n2knqj4z 251 5 for for IN cord-254317-n2knqj4z 251 6 S1 S1 NNP cord-254317-n2knqj4z 251 7 NTD NTD NNP cord-254317-n2knqj4z 251 8 - - HYPH cord-254317-n2knqj4z 251 9 del del NNP cord-254317-n2knqj4z 251 10 PEDV PEDV NNP cord-254317-n2knqj4z 251 11 alone alone RB cord-254317-n2knqj4z 251 12 . . . cord-254317-n2knqj4z 252 1 During during IN cord-254317-n2knqj4z 252 2 coinfection coinfection NN cord-254317-n2knqj4z 252 3 in in IN cord-254317-n2knqj4z 252 4 Vero Vero NNP cord-254317-n2knqj4z 252 5 cells cell NNS cord-254317-n2knqj4z 252 6 , , , cord-254317-n2knqj4z 252 7 icPC22A icPC22A NNP cord-254317-n2knqj4z 252 8 replicated replicate VBD cord-254317-n2knqj4z 252 9 to to IN cord-254317-n2knqj4z 252 10 a a DT cord-254317-n2knqj4z 252 11 titer titer NN cord-254317-n2knqj4z 252 12 of of IN cord-254317-n2knqj4z 252 13 10.10 10.10 CD cord-254317-n2knqj4z 252 14 ± ± CD cord-254317-n2knqj4z 252 15 0.05 0.05 CD cord-254317-n2knqj4z 252 16 log log NN cord-254317-n2knqj4z 253 1 10 10 CD cord-254317-n2knqj4z 253 2 copies copy NNS cord-254317-n2knqj4z 253 3 / / SYM cord-254317-n2knqj4z 253 4 mL ml NN cord-254317-n2knqj4z 253 5 at at IN cord-254317-n2knqj4z 253 6 72 72 CD cord-254317-n2knqj4z 253 7 hpi hpi NNP cord-254317-n2knqj4z 253 8 , , , cord-254317-n2knqj4z 253 9 which which WDT cord-254317-n2knqj4z 253 10 was be VBD cord-254317-n2knqj4z 253 11 similar similar JJ cord-254317-n2knqj4z 253 12 to to IN cord-254317-n2knqj4z 253 13 that that DT cord-254317-n2knqj4z 253 14 of of IN cord-254317-n2knqj4z 253 15 the the DT cord-254317-n2knqj4z 253 16 single single JJ cord-254317-n2knqj4z 253 17 infection infection NN cord-254317-n2knqj4z 253 18 ( ( -LRB- cord-254317-n2knqj4z 253 19 10.20 10.20 CD cord-254317-n2knqj4z 253 20 ± ± CD cord-254317-n2knqj4z 253 21 0.09 0.09 CD cord-254317-n2knqj4z 253 22 log log NN cord-254317-n2knqj4z 253 23 10 10 CD cord-254317-n2knqj4z 253 24 copies copy NNS cord-254317-n2knqj4z 253 25 / / SYM cord-254317-n2knqj4z 253 26 mL ml NN cord-254317-n2knqj4z 253 27 ) ) -RRB- cord-254317-n2knqj4z 254 1 ( ( -LRB- cord-254317-n2knqj4z 254 2 Fig Fig NNP cord-254317-n2knqj4z 254 3 . . . cord-254317-n2knqj4z 254 4 3A 3A NNP cord-254317-n2knqj4z 254 5 ) ) -RRB- cord-254317-n2knqj4z 254 6 . . . cord-254317-n2knqj4z 255 1 However however RB cord-254317-n2knqj4z 255 2 , , , cord-254317-n2knqj4z 255 3 icPC22A icPC22A NNP cord-254317-n2knqj4z 255 4 - - HYPH cord-254317-n2knqj4z 255 5 S1Δ197 S1Δ197 NNP cord-254317-n2knqj4z 255 6 S S NNP cord-254317-n2knqj4z 255 7 gene gene NN cord-254317-n2knqj4z 255 8 peak peak NN cord-254317-n2knqj4z 255 9 titer titer NN cord-254317-n2knqj4z 255 10 was be VBD cord-254317-n2knqj4z 255 11 9.80 9.80 CD cord-254317-n2knqj4z 255 12 ± ± CD cord-254317-n2knqj4z 255 13 0.03 0.03 CD cord-254317-n2knqj4z 255 14 log log NN cord-254317-n2knqj4z 256 1 10 10 CD cord-254317-n2knqj4z 256 2 copies/ copies/ NN cord-254317-n2knqj4z 256 3 mL ml NN cord-254317-n2knqj4z 256 4 , , , cord-254317-n2knqj4z 256 5 which which WDT cord-254317-n2knqj4z 256 6 was be VBD cord-254317-n2knqj4z 256 7 significantly significantly RB cord-254317-n2knqj4z 256 8 lower low JJR cord-254317-n2knqj4z 256 9 than than IN cord-254317-n2knqj4z 256 10 that that DT cord-254317-n2knqj4z 256 11 of of IN cord-254317-n2knqj4z 256 12 the the DT cord-254317-n2knqj4z 256 13 single single JJ cord-254317-n2knqj4z 256 14 infection infection NN cord-254317-n2knqj4z 256 15 ( ( -LRB- cord-254317-n2knqj4z 256 16 10.30 10.30 CD cord-254317-n2knqj4z 256 17 ± ± CD cord-254317-n2knqj4z 256 18 0.04 0.04 CD cord-254317-n2knqj4z 256 19 log log NN cord-254317-n2knqj4z 256 20 10 10 CD cord-254317-n2knqj4z 256 21 copies copy NNS cord-254317-n2knqj4z 256 22 / / SYM cord-254317-n2knqj4z 256 23 mL ml NN cord-254317-n2knqj4z 256 24 ) ) -RRB- cord-254317-n2knqj4z 256 25 . . . cord-254317-n2knqj4z 257 1 In in IN cord-254317-n2knqj4z 257 2 Vero Vero NNP cord-254317-n2knqj4z 257 3 cells cell NNS cord-254317-n2knqj4z 257 4 , , , cord-254317-n2knqj4z 257 5 icPC22A icPC22A NNP cord-254317-n2knqj4z 257 6 alone alone RB cord-254317-n2knqj4z 257 7 and and CC cord-254317-n2knqj4z 257 8 icPC22A icPC22A NNP cord-254317-n2knqj4z 257 9 - - HYPH cord-254317-n2knqj4z 257 10 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 257 11 alone alone RB cord-254317-n2knqj4z 257 12 replicated replicate VBD cord-254317-n2knqj4z 257 13 to to IN cord-254317-n2knqj4z 257 14 similar similar JJ cord-254317-n2knqj4z 257 15 titers titer NNS cord-254317-n2knqj4z 257 16 . . . cord-254317-n2knqj4z 258 1 Similarly similarly RB cord-254317-n2knqj4z 258 2 , , , cord-254317-n2knqj4z 258 3 during during IN cord-254317-n2knqj4z 258 4 coinfection coinfection NN cord-254317-n2knqj4z 258 5 in in IN cord-254317-n2knqj4z 258 6 IPEC IPEC NNP cord-254317-n2knqj4z 258 7 - - HYPH cord-254317-n2knqj4z 258 8 DQ dq NN cord-254317-n2knqj4z 258 9 cells cell NNS cord-254317-n2knqj4z 258 10 , , , cord-254317-n2knqj4z 258 11 icPC22A icPC22A NNP cord-254317-n2knqj4z 258 12 replicated replicate VBD cord-254317-n2knqj4z 258 13 to to IN cord-254317-n2knqj4z 258 14 a a DT cord-254317-n2knqj4z 258 15 similar similar JJ cord-254317-n2knqj4z 258 16 titer titer NN cord-254317-n2knqj4z 258 17 to to IN cord-254317-n2knqj4z 258 18 its -PRON- PRP$ cord-254317-n2knqj4z 258 19 single single JJ cord-254317-n2knqj4z 258 20 infection infection NN cord-254317-n2knqj4z 258 21 ( ( -LRB- cord-254317-n2knqj4z 258 22 8.60 8.60 CD cord-254317-n2knqj4z 258 23 ± ± CD cord-254317-n2knqj4z 258 24 0.18 0.18 CD cord-254317-n2knqj4z 258 25 vs. vs. NN cord-254317-n2knqj4z 258 26 8.70 8.70 CD cord-254317-n2knqj4z 258 27 ± ± CD cord-254317-n2knqj4z 258 28 0.11 0.11 CD cord-254317-n2knqj4z 258 29 log log NN cord-254317-n2knqj4z 259 1 10 10 CD cord-254317-n2knqj4z 259 2 copies copy NNS cord-254317-n2knqj4z 259 3 / / SYM cord-254317-n2knqj4z 259 4 mL ml NN cord-254317-n2knqj4z 259 5 at at IN cord-254317-n2knqj4z 259 6 48 48 CD cord-254317-n2knqj4z 259 7 hpi hpi NNP cord-254317-n2knqj4z 259 8 ( ( -LRB- cord-254317-n2knqj4z 259 9 Fig Fig NNP cord-254317-n2knqj4z 259 10 . . . cord-254317-n2knqj4z 259 11 3C 3C NNP cord-254317-n2knqj4z 259 12 ) ) -RRB- cord-254317-n2knqj4z 259 13 . . . cord-254317-n2knqj4z 260 1 icPC22A icpc22a CD cord-254317-n2knqj4z 260 2 - - HYPH cord-254317-n2knqj4z 260 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 260 4 S S NNP cord-254317-n2knqj4z 260 5 gene gene NN cord-254317-n2knqj4z 260 6 peak peak NN cord-254317-n2knqj4z 260 7 titer titer NN cord-254317-n2knqj4z 260 8 was be VBD cord-254317-n2knqj4z 260 9 7.03 7.03 CD cord-254317-n2knqj4z 260 10 ± ± NNP cord-254317-n2knqj4z 260 11 0.12 0.12 CD cord-254317-n2knqj4z 260 12 log log NN cord-254317-n2knqj4z 260 13 10 10 CD cord-254317-n2knqj4z 260 14 copies copy NNS cord-254317-n2knqj4z 260 15 / / SYM cord-254317-n2knqj4z 260 16 mL ml NN cord-254317-n2knqj4z 260 17 , , , cord-254317-n2knqj4z 260 18 which which WDT cord-254317-n2knqj4z 260 19 was be VBD cord-254317-n2knqj4z 260 20 significantly significantly RB cord-254317-n2knqj4z 260 21 lower low JJR cord-254317-n2knqj4z 260 22 than than IN cord-254317-n2knqj4z 260 23 that that DT cord-254317-n2knqj4z 260 24 of of IN cord-254317-n2knqj4z 260 25 the the DT cord-254317-n2knqj4z 260 26 single single JJ cord-254317-n2knqj4z 260 27 infection infection NN cord-254317-n2knqj4z 260 28 ( ( -LRB- cord-254317-n2knqj4z 260 29 7.49 7.49 CD cord-254317-n2knqj4z 260 30 ± ± CD cord-254317-n2knqj4z 260 31 0.25 0.25 CD cord-254317-n2knqj4z 260 32 log log NN cord-254317-n2knqj4z 260 33 10 10 CD cord-254317-n2knqj4z 260 34 copies copy NNS cord-254317-n2knqj4z 260 35 / / SYM cord-254317-n2knqj4z 260 36 mL ml NN cord-254317-n2knqj4z 260 37 ) ) -RRB- cord-254317-n2knqj4z 260 38 . . . cord-254317-n2knqj4z 261 1 In in IN cord-254317-n2knqj4z 261 2 contrast contrast NN cord-254317-n2knqj4z 261 3 to to IN cord-254317-n2knqj4z 261 4 those those DT cord-254317-n2knqj4z 261 5 results result NNS cord-254317-n2knqj4z 261 6 in in IN cord-254317-n2knqj4z 261 7 Vero Vero NNP cord-254317-n2knqj4z 261 8 cells cell NNS cord-254317-n2knqj4z 261 9 , , , cord-254317-n2knqj4z 261 10 icPC22A icPC22A NNP cord-254317-n2knqj4z 261 11 alone alone RB cord-254317-n2knqj4z 261 12 replicated replicate VBD cord-254317-n2knqj4z 261 13 to to IN cord-254317-n2knqj4z 261 14 significantly significantly RB cord-254317-n2knqj4z 261 15 higher high JJR cord-254317-n2knqj4z 261 16 titers titer NNS cord-254317-n2knqj4z 261 17 than than IN cord-254317-n2knqj4z 261 18 icPC22A icPC22A NNP cord-254317-n2knqj4z 261 19 - - HYPH cord-254317-n2knqj4z 261 20 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 261 21 alone alone RB cord-254317-n2knqj4z 261 22 in in IN cord-254317-n2knqj4z 261 23 IPEC IPEC NNP cord-254317-n2knqj4z 261 24 - - HYPH cord-254317-n2knqj4z 261 25 DQ dq NN cord-254317-n2knqj4z 261 26 cells cell NNS cord-254317-n2knqj4z 261 27 . . . cord-254317-n2knqj4z 262 1 By by IN cord-254317-n2knqj4z 262 2 IF if IN cord-254317-n2knqj4z 262 3 staining staining NN cord-254317-n2knqj4z 262 4 , , , cord-254317-n2knqj4z 262 5 more more JJR cord-254317-n2knqj4z 262 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 262 7 - - HYPH cord-254317-n2knqj4z 262 8 S1Δ197-infected s1δ197-infecte VBN cord-254317-n2knqj4z 262 9 cells cell NNS cord-254317-n2knqj4z 262 10 ( ( -LRB- cord-254317-n2knqj4z 262 11 green green JJ cord-254317-n2knqj4z 262 12 ) ) -RRB- cord-254317-n2knqj4z 262 13 were be VBD cord-254317-n2knqj4z 262 14 observed observe VBN cord-254317-n2knqj4z 262 15 in in IN cord-254317-n2knqj4z 262 16 Vero Vero NNP cord-254317-n2knqj4z 262 17 cells cell NNS cord-254317-n2knqj4z 262 18 than than IN cord-254317-n2knqj4z 262 19 in in IN cord-254317-n2knqj4z 262 20 IEPC IEPC NNP cord-254317-n2knqj4z 262 21 - - HYPH cord-254317-n2knqj4z 262 22 DQ DQ NNP cord-254317-n2knqj4z 262 23 cells cell NNS cord-254317-n2knqj4z 262 24 in in IN cord-254317-n2knqj4z 262 25 both both DT cord-254317-n2knqj4z 262 26 icPC22A icPC22A NNP cord-254317-n2knqj4z 262 27 - - HYPH cord-254317-n2knqj4z 262 28 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 262 29 alone alone RB cord-254317-n2knqj4z 262 30 and and CC cord-254317-n2knqj4z 262 31 co co NN cord-254317-n2knqj4z 262 32 - - NN cord-254317-n2knqj4z 262 33 infection infection JJ cord-254317-n2knqj4z 262 34 conditions condition NNS cord-254317-n2knqj4z 263 1 ( ( -LRB- cord-254317-n2knqj4z 263 2 Fig Fig NNP cord-254317-n2knqj4z 263 3 . . . cord-254317-n2knqj4z 263 4 3B 3B NNP cord-254317-n2knqj4z 263 5 and and CC cord-254317-n2knqj4z 263 6 D D NNP cord-254317-n2knqj4z 263 7 ) ) -RRB- cord-254317-n2knqj4z 263 8 . . . cord-254317-n2knqj4z 264 1 At at IN cord-254317-n2knqj4z 264 2 the the DT cord-254317-n2knqj4z 264 3 second second JJ cord-254317-n2knqj4z 264 4 passage passage NN cord-254317-n2knqj4z 264 5 of of IN cord-254317-n2knqj4z 264 6 the the DT cord-254317-n2knqj4z 264 7 coinfection coinfection NN cord-254317-n2knqj4z 264 8 , , , cord-254317-n2knqj4z 264 9 icPC22 icPC22 NNP cord-254317-n2knqj4z 264 10 A a DT cord-254317-n2knqj4z 264 11 RNA RNA NNP cord-254317-n2knqj4z 264 12 and and CC cord-254317-n2knqj4z 264 13 antigens antigen NNS cord-254317-n2knqj4z 264 14 were be VBD cord-254317-n2knqj4z 264 15 detected detect VBN cord-254317-n2knqj4z 264 16 in in IN cord-254317-n2knqj4z 264 17 both both DT cord-254317-n2knqj4z 264 18 cells cell NNS cord-254317-n2knqj4z 264 19 ; ; : cord-254317-n2knqj4z 264 20 however however RB cord-254317-n2knqj4z 264 21 , , , cord-254317-n2knqj4z 264 22 icPC22 icpc22 XX cord-254317-n2knqj4z 265 1 A a LS cord-254317-n2knqj4z 265 2 - - HYPH cord-254317-n2knqj4z 265 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 265 4 RNA rna NN cord-254317-n2knqj4z 265 5 and and CC cord-254317-n2knqj4z 265 6 antigens antigen NNS cord-254317-n2knqj4z 265 7 were be VBD cord-254317-n2knqj4z 265 8 detected detect VBN cord-254317-n2knqj4z 265 9 exclusively exclusively RB cord-254317-n2knqj4z 265 10 in in IN cord-254317-n2knqj4z 265 11 Vero Vero NNP cord-254317-n2knqj4z 265 12 cells cell NNS cord-254317-n2knqj4z 265 13 but but CC cord-254317-n2knqj4z 265 14 not not RB cord-254317-n2knqj4z 265 15 in in IN cord-254317-n2knqj4z 265 16 IPEC IPEC NNP cord-254317-n2knqj4z 265 17 - - HYPH cord-254317-n2knqj4z 265 18 DQ dq NN cord-254317-n2knqj4z 265 19 cells cell NNS cord-254317-n2knqj4z 265 20 ( ( -LRB- cord-254317-n2knqj4z 265 21 data datum NNS cord-254317-n2knqj4z 265 22 not not RB cord-254317-n2knqj4z 265 23 shown show VBN cord-254317-n2knqj4z 265 24 ) ) -RRB- cord-254317-n2knqj4z 265 25 . . . cord-254317-n2knqj4z 266 1 3.4 3.4 CD cord-254317-n2knqj4z 266 2 . . . cord-254317-n2knqj4z 267 1 The the DT cord-254317-n2knqj4z 267 2 percentage percentage NN cord-254317-n2knqj4z 267 3 of of IN cord-254317-n2knqj4z 267 4 infectivity infectivity NN cord-254317-n2knqj4z 267 5 of of IN cord-254317-n2knqj4z 267 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 267 7 was be VBD cord-254317-n2knqj4z 267 8 significantly significantly RB cord-254317-n2knqj4z 267 9 lower low JJR cord-254317-n2knqj4z 267 10 than than IN cord-254317-n2knqj4z 267 11 that that DT cord-254317-n2knqj4z 267 12 of of IN cord-254317-n2knqj4z 267 13 icPC22A icPC22A NNP cord-254317-n2knqj4z 267 14 - - HYPH cord-254317-n2knqj4z 267 15 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 267 16 in in IN cord-254317-n2knqj4z 267 17 NA NA NNP cord-254317-n2knqj4z 267 18 - - HYPH cord-254317-n2knqj4z 267 19 treated treat VBN cord-254317-n2knqj4z 267 20 Vero Vero NNP cord-254317-n2knqj4z 267 21 and and CC cord-254317-n2knqj4z 267 22 IPEC IPEC NNP cord-254317-n2knqj4z 267 23 - - HYPH cord-254317-n2knqj4z 267 24 DQ dq NN cord-254317-n2knqj4z 267 25 cells cell NNS cord-254317-n2knqj4z 267 26 After after IN cord-254317-n2knqj4z 267 27 removing remove VBG cord-254317-n2knqj4z 267 28 sialic sialic JJ cord-254317-n2knqj4z 267 29 acids acid NNS cord-254317-n2knqj4z 267 30 from from IN cord-254317-n2knqj4z 267 31 the the DT cord-254317-n2knqj4z 267 32 cell cell NN cord-254317-n2knqj4z 267 33 surface surface NN cord-254317-n2knqj4z 267 34 using use VBG cord-254317-n2knqj4z 267 35 250 250 CD cord-254317-n2knqj4z 267 36 mU mU NNP cord-254317-n2knqj4z 267 37 NA NA NNP cord-254317-n2knqj4z 267 38 in in IN cord-254317-n2knqj4z 267 39 Vero Vero NNP cord-254317-n2knqj4z 267 40 and and CC cord-254317-n2knqj4z 267 41 IPEC IPEC NNP cord-254317-n2knqj4z 267 42 - - HYPH cord-254317-n2knqj4z 267 43 DQ dq NN cord-254317-n2knqj4z 267 44 cells cell NNS cord-254317-n2knqj4z 267 45 , , , cord-254317-n2knqj4z 267 46 the the DT cord-254317-n2knqj4z 267 47 percentages percentage NNS cord-254317-n2knqj4z 267 48 of of IN cord-254317-n2knqj4z 267 49 infectivity infectivity NN cord-254317-n2knqj4z 267 50 of of IN cord-254317-n2knqj4z 267 51 icPC22A icPC22A NNP cord-254317-n2knqj4z 267 52 and and CC cord-254317-n2knqj4z 267 53 icPC22A icPC22A NNP cord-254317-n2knqj4z 267 54 - - HYPH cord-254317-n2knqj4z 267 55 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 267 56 were be VBD cord-254317-n2knqj4z 267 57 reduced reduce VBN cord-254317-n2knqj4z 267 58 significantly significantly RB cord-254317-n2knqj4z 267 59 ( ( -LRB- cord-254317-n2knqj4z 267 60 Fig Fig NNP cord-254317-n2knqj4z 267 61 . . . cord-254317-n2knqj4z 267 62 4 4 CD cord-254317-n2knqj4z 267 63 ) ) -RRB- cord-254317-n2knqj4z 267 64 . . . cord-254317-n2knqj4z 268 1 However however RB cord-254317-n2knqj4z 268 2 , , , cord-254317-n2knqj4z 268 3 in in IN cord-254317-n2knqj4z 268 4 both both DT cord-254317-n2knqj4z 268 5 cells cell NNS cord-254317-n2knqj4z 268 6 treated treat VBN cord-254317-n2knqj4z 268 7 with with IN cord-254317-n2knqj4z 268 8 NA NA NNP cord-254317-n2knqj4z 268 9 , , , cord-254317-n2knqj4z 268 10 the the DT cord-254317-n2knqj4z 268 11 percentages percentage NNS cord-254317-n2knqj4z 268 12 of of IN cord-254317-n2knqj4z 268 13 infectivity infectivity NN cord-254317-n2knqj4z 268 14 of of IN cord-254317-n2knqj4z 268 15 icPC22A icPC22A NNP cord-254317-n2knqj4z 268 16 were be VBD cord-254317-n2knqj4z 268 17 significantly significantly RB cord-254317-n2knqj4z 268 18 lower low JJR cord-254317-n2knqj4z 268 19 than than IN cord-254317-n2knqj4z 268 20 those those DT cord-254317-n2knqj4z 268 21 of of IN cord-254317-n2knqj4z 268 22 icPC22A icPC22A NNP cord-254317-n2knqj4z 268 23 - - HYPH cord-254317-n2knqj4z 268 24 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 268 25 . . . cord-254317-n2knqj4z 269 1 3.5 3.5 CD cord-254317-n2knqj4z 269 2 . . . cord-254317-n2knqj4z 270 1 Mucin mucin NN cord-254317-n2knqj4z 270 2 enhanced enhance VBD cord-254317-n2knqj4z 270 3 the the DT cord-254317-n2knqj4z 270 4 infectivity infectivity NN cord-254317-n2knqj4z 270 5 of of IN cord-254317-n2knqj4z 270 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 270 7 but but CC cord-254317-n2knqj4z 270 8 had have VBD cord-254317-n2knqj4z 270 9 no no DT cord-254317-n2knqj4z 270 10 or or CC cord-254317-n2knqj4z 270 11 inhibition inhibition NN cord-254317-n2knqj4z 270 12 effects effect NNS cord-254317-n2knqj4z 270 13 on on IN cord-254317-n2knqj4z 270 14 icPC22A icPC22A NNP cord-254317-n2knqj4z 270 15 - - HYPH cord-254317-n2knqj4z 270 16 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 270 17 in in IN cord-254317-n2knqj4z 270 18 both both CC cord-254317-n2knqj4z 270 19 Vero Vero NNP cord-254317-n2knqj4z 270 20 and and CC cord-254317-n2knqj4z 270 21 IPEC IPEC NNP cord-254317-n2knqj4z 270 22 - - HYPH cord-254317-n2knqj4z 270 23 DQ dq NN cord-254317-n2knqj4z 270 24 cells cell NNS cord-254317-n2knqj4z 270 25 In in IN cord-254317-n2knqj4z 270 26 Vero Vero NNP cord-254317-n2knqj4z 270 27 cells cell NNS cord-254317-n2knqj4z 270 28 , , , cord-254317-n2knqj4z 270 29 0.1 0.1 CD cord-254317-n2knqj4z 270 30 - - SYM cord-254317-n2knqj4z 270 31 0.3 0.3 CD cord-254317-n2knqj4z 270 32 , , , cord-254317-n2knqj4z 270 33 0.5 0.5 CD cord-254317-n2knqj4z 270 34 and and CC cord-254317-n2knqj4z 270 35 1.0 1.0 CD cord-254317-n2knqj4z 270 36 mg mg NN cord-254317-n2knqj4z 270 37 / / SYM cord-254317-n2knqj4z 270 38 mL ml NN cord-254317-n2knqj4z 270 39 BM bm NN cord-254317-n2knqj4z 271 1 increased increase VBN cord-254317-n2knqj4z 271 2 , , , cord-254317-n2knqj4z 271 3 had have VBD cord-254317-n2knqj4z 271 4 no no DT cord-254317-n2knqj4z 271 5 effects effect NNS cord-254317-n2knqj4z 271 6 and and CC cord-254317-n2knqj4z 271 7 decreased decrease VBD cord-254317-n2knqj4z 271 8 the the DT cord-254317-n2knqj4z 271 9 infectivity infectivity NN cord-254317-n2knqj4z 271 10 of of IN cord-254317-n2knqj4z 271 11 icPC22A icPC22A NNP cord-254317-n2knqj4z 271 12 , , , cord-254317-n2knqj4z 271 13 respectively respectively RB cord-254317-n2knqj4z 271 14 ( ( -LRB- cord-254317-n2knqj4z 271 15 Fig fig NN cord-254317-n2knqj4z 271 16 . . . cord-254317-n2knqj4z 271 17 5A 5a CD cord-254317-n2knqj4z 271 18 ) ) -RRB- cord-254317-n2knqj4z 271 19 . . . cord-254317-n2knqj4z 272 1 0.5 0.5 CD cord-254317-n2knqj4z 272 2 - - HYPH cord-254317-n2knqj4z 272 3 5.0 5.0 CD cord-254317-n2knqj4z 272 4 mg mg NN cord-254317-n2knqj4z 272 5 / / SYM cord-254317-n2knqj4z 272 6 mL mL NNP cord-254317-n2knqj4z 272 7 PGM PGM NNP cord-254317-n2knqj4z 272 8 increased increase VBD cord-254317-n2knqj4z 272 9 the the DT cord-254317-n2knqj4z 272 10 infectivity infectivity NN cord-254317-n2knqj4z 272 11 of of IN cord-254317-n2knqj4z 272 12 icPC22A icPC22A NNP cord-254317-n2knqj4z 272 13 1.7 1.7 CD cord-254317-n2knqj4z 272 14 - - SYM cord-254317-n2knqj4z 272 15 2.5 2.5 CD cord-254317-n2knqj4z 272 16 fold fold VBP cord-254317-n2knqj4z 272 17 ( ( -LRB- cord-254317-n2knqj4z 272 18 Fig fig NN cord-254317-n2knqj4z 272 19 . . . cord-254317-n2knqj4z 272 20 5B 5b CD cord-254317-n2knqj4z 272 21 ) ) -RRB- cord-254317-n2knqj4z 272 22 . . . cord-254317-n2knqj4z 273 1 However however RB cord-254317-n2knqj4z 273 2 , , , cord-254317-n2knqj4z 273 3 the the DT cord-254317-n2knqj4z 273 4 infectivity infectivity NN cord-254317-n2knqj4z 273 5 of of IN cord-254317-n2knqj4z 273 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 273 7 - - HYPH cord-254317-n2knqj4z 273 8 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 273 9 was be VBD cord-254317-n2knqj4z 273 10 unaffected unaffected JJ cord-254317-n2knqj4z 273 11 or or CC cord-254317-n2knqj4z 273 12 inhibited inhibit VBN cord-254317-n2knqj4z 273 13 significantly significantly RB cord-254317-n2knqj4z 273 14 by by IN cord-254317-n2knqj4z 273 15 BM BM NNP cord-254317-n2knqj4z 273 16 and and CC cord-254317-n2knqj4z 273 17 PGM PGM NNP cord-254317-n2knqj4z 273 18 at at IN cord-254317-n2knqj4z 273 19 the the DT cord-254317-n2knqj4z 273 20 tested test VBN cord-254317-n2knqj4z 273 21 concentration concentration NN cord-254317-n2knqj4z 273 22 ( ( -LRB- cord-254317-n2knqj4z 273 23 Fig Fig NNP cord-254317-n2knqj4z 273 24 . . . cord-254317-n2knqj4z 273 25 5A 5a NN cord-254317-n2knqj4z 273 26 and and CC cord-254317-n2knqj4z 273 27 5B 5b NN cord-254317-n2knqj4z 273 28 ) ) -RRB- cord-254317-n2knqj4z 273 29 . . . cord-254317-n2knqj4z 274 1 In in IN cord-254317-n2knqj4z 274 2 IPEC IPEC NNP cord-254317-n2knqj4z 274 3 - - HYPH cord-254317-n2knqj4z 274 4 DQ dq NN cord-254317-n2knqj4z 274 5 cells cell NNS cord-254317-n2knqj4z 274 6 , , , cord-254317-n2knqj4z 274 7 the the DT cord-254317-n2knqj4z 274 8 infectivity infectivity NN cord-254317-n2knqj4z 274 9 of of IN cord-254317-n2knqj4z 274 10 icPC22A icPC22A NNP cord-254317-n2knqj4z 274 11 was be VBD cord-254317-n2knqj4z 274 12 increased increase VBN cord-254317-n2knqj4z 274 13 1.7 1.7 CD cord-254317-n2knqj4z 274 14 - - SYM cord-254317-n2knqj4z 274 15 2.6 2.6 CD cord-254317-n2knqj4z 274 16 fold fold NN cord-254317-n2knqj4z 274 17 and and CC cord-254317-n2knqj4z 274 18 2.6 2.6 CD cord-254317-n2knqj4z 274 19 - - SYM cord-254317-n2knqj4z 274 20 3.8 3.8 CD cord-254317-n2knqj4z 274 21 fold fold NN cord-254317-n2knqj4z 274 22 by by IN cord-254317-n2knqj4z 274 23 BM BM NNP cord-254317-n2knqj4z 274 24 ( ( -LRB- cord-254317-n2knqj4z 274 25 0.1 0.1 CD cord-254317-n2knqj4z 274 26 - - SYM cord-254317-n2knqj4z 274 27 1.0 1.0 CD cord-254317-n2knqj4z 274 28 mg mg NNP cord-254317-n2knqj4z 274 29 / / SYM cord-254317-n2knqj4z 274 30 mL mL NNP cord-254317-n2knqj4z 274 31 ) ) -RRB- cord-254317-n2knqj4z 274 32 and and CC cord-254317-n2knqj4z 274 33 PGM PGM NNP cord-254317-n2knqj4z 274 34 ( ( -LRB- cord-254317-n2knqj4z 274 35 0.5 0.5 CD cord-254317-n2knqj4z 274 36 - - SYM cord-254317-n2knqj4z 274 37 2.5 2.5 CD cord-254317-n2knqj4z 274 38 mg/ mg/ NN cord-254317-n2knqj4z 274 39 mL ml NN cord-254317-n2knqj4z 274 40 ) ) -RRB- cord-254317-n2knqj4z 274 41 , , , cord-254317-n2knqj4z 274 42 respectively respectively RB cord-254317-n2knqj4z 274 43 . . . cord-254317-n2knqj4z 275 1 However however RB cord-254317-n2knqj4z 275 2 , , , cord-254317-n2knqj4z 275 3 there there EX cord-254317-n2knqj4z 275 4 was be VBD cord-254317-n2knqj4z 275 5 no no DT cord-254317-n2knqj4z 275 6 effects effect NNS cord-254317-n2knqj4z 275 7 at at IN cord-254317-n2knqj4z 275 8 the the DT cord-254317-n2knqj4z 275 9 highest high JJS cord-254317-n2knqj4z 275 10 PGM PGM NNP cord-254317-n2knqj4z 275 11 concentration concentration NN cord-254317-n2knqj4z 275 12 tested test VBD cord-254317-n2knqj4z 275 13 ( ( -LRB- cord-254317-n2knqj4z 275 14 5.0 5.0 CD cord-254317-n2knqj4z 275 15 mg mg NNP cord-254317-n2knqj4z 275 16 / / SYM cord-254317-n2knqj4z 275 17 mL mL NNP cord-254317-n2knqj4z 275 18 ) ) -RRB- cord-254317-n2knqj4z 275 19 . . . cord-254317-n2knqj4z 276 1 On on IN cord-254317-n2knqj4z 276 2 the the DT cord-254317-n2knqj4z 276 3 other other JJ cord-254317-n2knqj4z 276 4 hand hand NN cord-254317-n2knqj4z 276 5 , , , cord-254317-n2knqj4z 276 6 low low JJ cord-254317-n2knqj4z 276 7 to to IN cord-254317-n2knqj4z 276 8 medium medium JJ cord-254317-n2knqj4z 276 9 concentrations concentration NNS cord-254317-n2knqj4z 276 10 of of IN cord-254317-n2knqj4z 276 11 BM BM NNP cord-254317-n2knqj4z 276 12 ( ( -LRB- cord-254317-n2knqj4z 276 13 0.1 0.1 CD cord-254317-n2knqj4z 276 14 - - SYM cord-254317-n2knqj4z 276 15 0.5 0.5 CD cord-254317-n2knqj4z 276 16 mg mg NNP cord-254317-n2knqj4z 276 17 / / SYM cord-254317-n2knqj4z 276 18 mL mL NNP cord-254317-n2knqj4z 276 19 ) ) -RRB- cord-254317-n2knqj4z 276 20 and and CC cord-254317-n2knqj4z 276 21 PGM PGM NNP cord-254317-n2knqj4z 276 22 ( ( -LRB- cord-254317-n2knqj4z 276 23 0.5 0.5 CD cord-254317-n2knqj4z 276 24 - - SYM cord-254317-n2knqj4z 276 25 1.0 1.0 CD cord-254317-n2knqj4z 276 26 mg mg NNP cord-254317-n2knqj4z 276 27 / / SYM cord-254317-n2knqj4z 276 28 mL mL NNP cord-254317-n2knqj4z 276 29 ) ) -RRB- cord-254317-n2knqj4z 276 30 had have VBD cord-254317-n2knqj4z 276 31 no no DT cord-254317-n2knqj4z 276 32 effects effect NNS cord-254317-n2knqj4z 276 33 on on IN cord-254317-n2knqj4z 276 34 the the DT cord-254317-n2knqj4z 276 35 infectivity infectivity NN cord-254317-n2knqj4z 276 36 of of IN cord-254317-n2knqj4z 276 37 icPC22 icPC22 NNP cord-254317-n2knqj4z 276 38 A A NNP cord-254317-n2knqj4z 276 39 - - HYPH cord-254317-n2knqj4z 276 40 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 276 41 . . . cord-254317-n2knqj4z 277 1 Only only RB cord-254317-n2knqj4z 277 2 high high JJ cord-254317-n2knqj4z 277 3 concentrations concentration NNS cord-254317-n2knqj4z 277 4 of of IN cord-254317-n2knqj4z 277 5 BM BM NNP cord-254317-n2knqj4z 277 6 ( ( -LRB- cord-254317-n2knqj4z 277 7 1.0 1.0 CD cord-254317-n2knqj4z 277 8 mg mg NN cord-254317-n2knqj4z 277 9 / / SYM cord-254317-n2knqj4z 277 10 mL mL NNP cord-254317-n2knqj4z 277 11 ) ) -RRB- cord-254317-n2knqj4z 277 12 and and CC cord-254317-n2knqj4z 277 13 PGM PGM NNP cord-254317-n2knqj4z 277 14 ( ( -LRB- cord-254317-n2knqj4z 277 15 2.5 2.5 CD cord-254317-n2knqj4z 277 16 - - SYM cord-254317-n2knqj4z 277 17 5.0 5.0 CD cord-254317-n2knqj4z 277 18 mg mg NNP cord-254317-n2knqj4z 277 19 / / SYM cord-254317-n2knqj4z 277 20 mL mL NNP cord-254317-n2knqj4z 277 21 ) ) -RRB- cord-254317-n2knqj4z 277 22 reduced reduce VBD cord-254317-n2knqj4z 277 23 the the DT cord-254317-n2knqj4z 277 24 infectivity infectivity NN cord-254317-n2knqj4z 277 25 of of IN cord-254317-n2knqj4z 277 26 icPC22 icpc22 NN cord-254317-n2knqj4z 278 1 A a LS cord-254317-n2knqj4z 278 2 - - HYPH cord-254317-n2knqj4z 278 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 278 4 significantly significantly RB cord-254317-n2knqj4z 278 5 ( ( -LRB- cord-254317-n2knqj4z 278 6 Fig Fig NNP cord-254317-n2knqj4z 278 7 . . . cord-254317-n2knqj4z 278 8 5C 5C NNP cord-254317-n2knqj4z 278 9 and and CC cord-254317-n2knqj4z 278 10 5D 5D NNP cord-254317-n2knqj4z 278 11 ) ) -RRB- cord-254317-n2knqj4z 278 12 . . . cord-254317-n2knqj4z 279 1 3.6 3.6 CD cord-254317-n2knqj4z 279 2 . . . cord-254317-n2knqj4z 280 1 Bile bile NN cord-254317-n2knqj4z 280 2 and and CC cord-254317-n2knqj4z 280 3 bile bile NN cord-254317-n2knqj4z 280 4 acids acid NNS cord-254317-n2knqj4z 280 5 enhanced enhance VBD cord-254317-n2knqj4z 280 6 the the DT cord-254317-n2knqj4z 280 7 infectivity infectivity NN cord-254317-n2knqj4z 280 8 of of IN cord-254317-n2knqj4z 280 9 icPC22A icPC22A NNP cord-254317-n2knqj4z 280 10 but but CC cord-254317-n2knqj4z 280 11 had have VBD cord-254317-n2knqj4z 280 12 no no DT cord-254317-n2knqj4z 280 13 or or CC cord-254317-n2knqj4z 280 14 inhibition inhibition NN cord-254317-n2knqj4z 280 15 effects effect NNS cord-254317-n2knqj4z 280 16 on on IN cord-254317-n2knqj4z 280 17 icPC22A icPC22A NNP cord-254317-n2knqj4z 280 18 - - HYPH cord-254317-n2knqj4z 280 19 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 281 1 In in IN cord-254317-n2knqj4z 281 2 Vero Vero NNP cord-254317-n2knqj4z 281 3 cells cell NNS cord-254317-n2knqj4z 281 4 , , , cord-254317-n2knqj4z 281 5 low low JJ cord-254317-n2knqj4z 281 6 to to IN cord-254317-n2knqj4z 281 7 medium medium JJ cord-254317-n2knqj4z 281 8 concentrations concentration NNS cord-254317-n2knqj4z 281 9 of of IN cord-254317-n2knqj4z 281 10 swine swine NN cord-254317-n2knqj4z 281 11 bile bile NN cord-254317-n2knqj4z 281 12 ( ( -LRB- cord-254317-n2knqj4z 281 13 0.1 0.1 CD cord-254317-n2knqj4z 281 14 - - SYM cord-254317-n2knqj4z 281 15 0.5 0.5 CD cord-254317-n2knqj4z 281 16 % % NN cord-254317-n2knqj4z 281 17 ) ) -RRB- cord-254317-n2knqj4z 281 18 increased increase VBD cord-254317-n2knqj4z 281 19 2.4 2.4 CD cord-254317-n2knqj4z 281 20 - - SYM cord-254317-n2knqj4z 281 21 3.3 3.3 CD cord-254317-n2knqj4z 281 22 fold fold NN cord-254317-n2knqj4z 281 23 of of IN cord-254317-n2knqj4z 281 24 the the DT cord-254317-n2knqj4z 281 25 infectivity infectivity NN cord-254317-n2knqj4z 281 26 of of IN cord-254317-n2knqj4z 281 27 icPC22A icPC22A NNP cord-254317-n2knqj4z 281 28 ( ( -LRB- cord-254317-n2knqj4z 281 29 Fig Fig NNP cord-254317-n2knqj4z 281 30 . . . cord-254317-n2knqj4z 281 31 6A 6a CD cord-254317-n2knqj4z 281 32 ) ) -RRB- cord-254317-n2knqj4z 281 33 . . . cord-254317-n2knqj4z 282 1 ( ( -LRB- cord-254317-n2knqj4z 282 2 Fig Fig NNP cord-254317-n2knqj4z 282 3 . . . cord-254317-n2knqj4z 282 4 6B 6b CD cord-254317-n2knqj4z 282 5 - - HYPH cord-254317-n2knqj4z 282 6 E E NNP cord-254317-n2knqj4z 282 7 ) ) -RRB- cord-254317-n2knqj4z 282 8 . . . cord-254317-n2knqj4z 283 1 However however RB cord-254317-n2knqj4z 283 2 , , , cord-254317-n2knqj4z 283 3 the the DT cord-254317-n2knqj4z 283 4 infectivity infectivity NN cord-254317-n2knqj4z 283 5 of of IN cord-254317-n2knqj4z 283 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 283 7 - - HYPH cord-254317-n2knqj4z 283 8 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 283 9 was be VBD cord-254317-n2knqj4z 283 10 unaffected unaffected JJ cord-254317-n2knqj4z 283 11 ( ( -LRB- cord-254317-n2knqj4z 283 12 0.1 0.1 CD cord-254317-n2knqj4z 283 13 - - SYM cord-254317-n2knqj4z 283 14 0.3 0.3 CD cord-254317-n2knqj4z 283 15 % % NN cord-254317-n2knqj4z 283 16 ) ) -RRB- cord-254317-n2knqj4z 283 17 or or CC cord-254317-n2knqj4z 283 18 inhibited inhibit VBN cord-254317-n2knqj4z 283 19 significantly significantly RB cord-254317-n2knqj4z 283 20 by by IN cord-254317-n2knqj4z 283 21 bile bile NN cord-254317-n2knqj4z 283 22 ( ( -LRB- cord-254317-n2knqj4z 283 23 0.5 0.5 CD cord-254317-n2knqj4z 283 24 - - SYM cord-254317-n2knqj4z 283 25 1.0 1.0 CD cord-254317-n2knqj4z 283 26 % % NN cord-254317-n2knqj4z 283 27 ) ) -RRB- cord-254317-n2knqj4z 283 28 by by IN cord-254317-n2knqj4z 283 29 bile bile NN cord-254317-n2knqj4z 283 30 ( ( -LRB- cord-254317-n2knqj4z 283 31 Fig fig NN cord-254317-n2knqj4z 283 32 . . . cord-254317-n2knqj4z 283 33 6A 6a CD cord-254317-n2knqj4z 283 34 ) ) -RRB- cord-254317-n2knqj4z 283 35 . . . cord-254317-n2knqj4z 284 1 Bile bile NN cord-254317-n2knqj4z 284 2 acids acid NNS cord-254317-n2knqj4z 284 3 _SP cord-254317-n2knqj4z 285 1 a a DT cord-254317-n2knqj4z 285 2 Piglets Piglets NNP cord-254317-n2knqj4z 285 3 in in IN cord-254317-n2knqj4z 285 4 group group NN cord-254317-n2knqj4z 285 5 1 1 CD cord-254317-n2knqj4z 285 6 were be VBD cord-254317-n2knqj4z 285 7 inoculated inoculate VBN cord-254317-n2knqj4z 285 8 with with IN cord-254317-n2knqj4z 285 9 100 100 CD cord-254317-n2knqj4z 285 10 PFU pfu NN cord-254317-n2knqj4z 285 11 / / SYM cord-254317-n2knqj4z 285 12 pig pig NN cord-254317-n2knqj4z 285 13 of of IN cord-254317-n2knqj4z 285 14 icPC22 icPC22 NNP cord-254317-n2knqj4z 285 15 A a NN cord-254317-n2knqj4z 285 16 ; ; : cord-254317-n2knqj4z 285 17 Piglets piglet NNS cord-254317-n2knqj4z 285 18 in in IN cord-254317-n2knqj4z 285 19 group group NN cord-254317-n2knqj4z 285 20 2 2 CD cord-254317-n2knqj4z 285 21 were be VBD cord-254317-n2knqj4z 285 22 inoculated inoculate VBN cord-254317-n2knqj4z 285 23 with with IN cord-254317-n2knqj4z 285 24 100 100 CD cord-254317-n2knqj4z 285 25 PFU pfu NN cord-254317-n2knqj4z 285 26 / / SYM cord-254317-n2knqj4z 285 27 pig pig NN cord-254317-n2knqj4z 285 28 of of IN cord-254317-n2knqj4z 285 29 icPC22A icPC22A NNP cord-254317-n2knqj4z 285 30 - - HYPH cord-254317-n2knqj4z 285 31 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 285 32 ; ; : cord-254317-n2knqj4z 285 33 Piglets piglet NNS cord-254317-n2knqj4z 285 34 in in IN cord-254317-n2knqj4z 285 35 group group NN cord-254317-n2knqj4z 285 36 3 3 CD cord-254317-n2knqj4z 285 37 were be VBD cord-254317-n2knqj4z 285 38 inoculated inoculate VBN cord-254317-n2knqj4z 285 39 with with IN cord-254317-n2knqj4z 285 40 100 100 CD cord-254317-n2knqj4z 285 41 PFU pfu NN cord-254317-n2knqj4z 285 42 / / SYM cord-254317-n2knqj4z 285 43 pig pig NN cord-254317-n2knqj4z 285 44 of of IN cord-254317-n2knqj4z 285 45 each each DT cord-254317-n2knqj4z 285 46 virus virus NN cord-254317-n2knqj4z 285 47 ; ; : cord-254317-n2knqj4z 285 48 Piglets piglet NNS cord-254317-n2knqj4z 285 49 in in IN cord-254317-n2knqj4z 285 50 group group NN cord-254317-n2knqj4z 285 51 4 4 CD cord-254317-n2knqj4z 285 52 were be VBD cord-254317-n2knqj4z 285 53 inoculated inoculate VBN cord-254317-n2knqj4z 285 54 with with IN cord-254317-n2knqj4z 285 55 PBS PBS NNP cord-254317-n2knqj4z 285 56 ; ; : cord-254317-n2knqj4z 285 57 Piglets piglet NNS cord-254317-n2knqj4z 285 58 in in IN cord-254317-n2knqj4z 285 59 group group NN cord-254317-n2knqj4z 285 60 5 5 CD cord-254317-n2knqj4z 285 61 were be VBD cord-254317-n2knqj4z 285 62 inoculated inoculate VBN cord-254317-n2knqj4z 285 63 with with IN cord-254317-n2knqj4z 285 64 the the DT cord-254317-n2knqj4z 285 65 SIC sic NN cord-254317-n2knqj4z 285 66 of of IN cord-254317-n2knqj4z 285 67 piglet piglet NN cord-254317-n2knqj4z 285 68 in in IN cord-254317-n2knqj4z 285 69 group group NN cord-254317-n2knqj4z 285 70 3 3 CD cord-254317-n2knqj4z 285 71 with with IN cord-254317-n2knqj4z 285 72 a a DT cord-254317-n2knqj4z 285 73 dose dose NN cord-254317-n2knqj4z 285 74 of of IN cord-254317-n2knqj4z 285 75 4 4 CD cord-254317-n2knqj4z 285 76 log log NN cord-254317-n2knqj4z 285 77 10 10 CD cord-254317-n2knqj4z 286 1 PFU pfu NN cord-254317-n2knqj4z 286 2 / / SYM cord-254317-n2knqj4z 286 3 mL ml NN cord-254317-n2knqj4z 286 4 targeting target VBG cord-254317-n2knqj4z 286 5 N n CD cord-254317-n2knqj4z 286 6 gene gene NN cord-254317-n2knqj4z 286 7 of of IN cord-254317-n2knqj4z 286 8 PEDV PEDV NNP cord-254317-n2knqj4z 286 9 . . . cord-254317-n2knqj4z 287 1 b b LS cord-254317-n2knqj4z 287 2 Fecal fecal JJ cord-254317-n2knqj4z 287 3 consistency consistency NN cord-254317-n2knqj4z 287 4 ( ( -LRB- cord-254317-n2knqj4z 287 5 FC FC NNP cord-254317-n2knqj4z 287 6 ) ) -RRB- cord-254317-n2knqj4z 287 7 was be VBD cord-254317-n2knqj4z 287 8 scored score VBN cord-254317-n2knqj4z 287 9 as as IN cord-254317-n2knqj4z 287 10 follows follow VBZ cord-254317-n2knqj4z 287 11 : : : cord-254317-n2knqj4z 287 12 0 0 NFP cord-254317-n2knqj4z 287 13 , , , cord-254317-n2knqj4z 287 14 solid solid JJ cord-254317-n2knqj4z 287 15 , , , cord-254317-n2knqj4z 287 16 1 1 CD cord-254317-n2knqj4z 287 17 , , , cord-254317-n2knqj4z 287 18 pasty pasty JJ cord-254317-n2knqj4z 287 19 , , , cord-254317-n2knqj4z 287 20 2 2 CD cord-254317-n2knqj4z 287 21 , , , cord-254317-n2knqj4z 287 22 semiliquid semiliquid JJ cord-254317-n2knqj4z 287 23 ; ; : cord-254317-n2knqj4z 287 24 and and CC cord-254317-n2knqj4z 287 25 3 3 CD cord-254317-n2knqj4z 287 26 , , , cord-254317-n2knqj4z 287 27 liquid liquid JJ cord-254317-n2knqj4z 287 28 . . . cord-254317-n2knqj4z 288 1 An an DT cord-254317-n2knqj4z 288 2 FC FC NNP cord-254317-n2knqj4z 288 3 score score NN cord-254317-n2knqj4z 288 4 of of IN cord-254317-n2knqj4z 288 5 2 2 CD cord-254317-n2knqj4z 288 6 and and CC cord-254317-n2knqj4z 288 7 3 3 CD cord-254317-n2knqj4z 288 8 were be VBD cord-254317-n2knqj4z 288 9 considered consider VBN cord-254317-n2knqj4z 288 10 diarrhea diarrhea JJ cord-254317-n2knqj4z 288 11 and and CC cord-254317-n2knqj4z 288 12 severe severe JJ cord-254317-n2knqj4z 288 13 diarrhea diarrhea NN cord-254317-n2knqj4z 288 14 , , , cord-254317-n2knqj4z 288 15 respectively respectively RB cord-254317-n2knqj4z 288 16 . . . cord-254317-n2knqj4z 289 1 c c LS cord-254317-n2knqj4z 289 2 Values value NNS cord-254317-n2knqj4z 289 3 in in IN cord-254317-n2knqj4z 289 4 parentheses parenthesis NNS cord-254317-n2knqj4z 289 5 are be VBP cord-254317-n2knqj4z 289 6 the the DT cord-254317-n2knqj4z 289 7 number number NN cord-254317-n2knqj4z 289 8 of of IN cord-254317-n2knqj4z 289 9 positive positive JJ cord-254317-n2knqj4z 289 10 results result NNS cord-254317-n2knqj4z 289 11 / / SYM cord-254317-n2knqj4z 289 12 number number NN cord-254317-n2knqj4z 289 13 of of IN cord-254317-n2knqj4z 289 14 animals animal NNS cord-254317-n2knqj4z 289 15 tested test VBN cord-254317-n2knqj4z 289 16 . . . cord-254317-n2knqj4z 290 1 d d LS cord-254317-n2knqj4z 290 2 The the DT cord-254317-n2knqj4z 290 3 detection detection NN cord-254317-n2knqj4z 290 4 limit limit NN cord-254317-n2knqj4z 290 5 of of IN cord-254317-n2knqj4z 290 6 PEDV PEDV NNP cord-254317-n2knqj4z 290 7 RT RT NNP cord-254317-n2knqj4z 290 8 - - HYPH cord-254317-n2knqj4z 290 9 qPCR qPCR NNP cord-254317-n2knqj4z 290 10 targeting target VBG cord-254317-n2knqj4z 290 11 the the DT cord-254317-n2knqj4z 290 12 S S NNP cord-254317-n2knqj4z 290 13 gene gene NN cord-254317-n2knqj4z 290 14 of of IN cord-254317-n2knqj4z 290 15 icPC22A icPC22A NNP cord-254317-n2knqj4z 290 16 or or CC cord-254317-n2knqj4z 290 17 icPC22 icpc22 NN cord-254317-n2knqj4z 291 1 A a LS cord-254317-n2knqj4z 291 2 - - HYPH cord-254317-n2knqj4z 291 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 291 4 is be VBZ cord-254317-n2knqj4z 291 5 5 5 CD cord-254317-n2knqj4z 291 6 log log VBP cord-254317-n2knqj4z 291 7 10 10 CD cord-254317-n2knqj4z 291 8 copies copy NNS cord-254317-n2knqj4z 291 9 / / SYM cord-254317-n2knqj4z 291 10 mL. ml. NN cord-254317-n2knqj4z 291 11 e e NNP cord-254317-n2knqj4z 292 1 The the DT cord-254317-n2knqj4z 292 2 detection detection NN cord-254317-n2knqj4z 292 3 limit limit NN cord-254317-n2knqj4z 292 4 of of IN cord-254317-n2knqj4z 292 5 PEDV PEDV NNP cord-254317-n2knqj4z 292 6 RT RT NNP cord-254317-n2knqj4z 292 7 - - HYPH cord-254317-n2knqj4z 292 8 qPCR qPCR NNP cord-254317-n2knqj4z 292 9 targeting target VBG cord-254317-n2knqj4z 292 10 the the DT cord-254317-n2knqj4z 292 11 N n CD cord-254317-n2knqj4z 292 12 gene gene NN cord-254317-n2knqj4z 292 13 of of IN cord-254317-n2knqj4z 292 14 both both DT cord-254317-n2knqj4z 292 15 icPC22A icPC22A NNP cord-254317-n2knqj4z 292 16 and and CC cord-254317-n2knqj4z 292 17 icPC22 icpc22 NN cord-254317-n2knqj4z 293 1 A a LS cord-254317-n2knqj4z 293 2 - - HYPH cord-254317-n2knqj4z 293 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 293 4 is be VBZ cord-254317-n2knqj4z 293 5 4.8 4.8 CD cord-254317-n2knqj4z 293 6 log log NN cord-254317-n2knqj4z 294 1 10 10 CD cord-254317-n2knqj4z 294 2 copies copy NNS cord-254317-n2knqj4z 294 3 / / SYM cord-254317-n2knqj4z 294 4 mL ml NN cord-254317-n2knqj4z 294 5 . . . cord-254317-n2knqj4z 295 1 f f LS cord-254317-n2knqj4z 295 2 The the DT cord-254317-n2knqj4z 295 3 pig pig NN cord-254317-n2knqj4z 295 4 number number NN cord-254317-n2knqj4z 295 5 for for IN cord-254317-n2knqj4z 295 6 diarrhea diarrhea JJ cord-254317-n2knqj4z 295 7 observation observation NN cord-254317-n2knqj4z 295 8 is be VBZ cord-254317-n2knqj4z 295 9 1 1 CD cord-254317-n2knqj4z 295 10 or or CC cord-254317-n2knqj4z 295 11 2 2 CD cord-254317-n2knqj4z 295 12 less less JJR cord-254317-n2knqj4z 295 13 than than IN cord-254317-n2knqj4z 295 14 the the DT cord-254317-n2knqj4z 295 15 total total JJ cord-254317-n2knqj4z 295 16 pig pig NN cord-254317-n2knqj4z 295 17 number number NN cord-254317-n2knqj4z 295 18 because because IN cord-254317-n2knqj4z 295 19 1 1 CD cord-254317-n2knqj4z 295 20 or or CC cord-254317-n2knqj4z 295 21 2 2 CD cord-254317-n2knqj4z 295 22 pigs pig NNS cord-254317-n2knqj4z 295 23 of of IN cord-254317-n2knqj4z 295 24 each each DT cord-254317-n2knqj4z 295 25 group group NN cord-254317-n2knqj4z 295 26 were be VBD cord-254317-n2knqj4z 295 27 euthanized euthanize VBN cord-254317-n2knqj4z 295 28 at at IN cord-254317-n2knqj4z 295 29 12 12 CD cord-254317-n2knqj4z 295 30 hpi hpi NNP cord-254317-n2knqj4z 295 31 . . . cord-254317-n2knqj4z 296 1 g g NNP cord-254317-n2knqj4z 297 1 The the DT cord-254317-n2knqj4z 297 2 experimental experimental JJ cord-254317-n2knqj4z 297 3 data datum NNS cord-254317-n2knqj4z 297 4 were be VBD cord-254317-n2knqj4z 297 5 analyzed analyze VBN cord-254317-n2knqj4z 297 6 by by IN cord-254317-n2knqj4z 297 7 Student`s student`s NN cord-254317-n2knqj4z 297 8 t t NN cord-254317-n2knqj4z 297 9 - - HYPH cord-254317-n2knqj4z 297 10 test test NN cord-254317-n2knqj4z 297 11 . . . cord-254317-n2knqj4z 298 1 Letters letter NNS cord-254317-n2knqj4z 298 2 ' ' POS cord-254317-n2knqj4z 298 3 A A NNP cord-254317-n2knqj4z 298 4 , , , cord-254317-n2knqj4z 298 5 B B NNP cord-254317-n2knqj4z 298 6 and and CC cord-254317-n2knqj4z 298 7 C C NNP cord-254317-n2knqj4z 298 8 ' ' '' cord-254317-n2knqj4z 298 9 indicate indicate VBP cord-254317-n2knqj4z 298 10 a a DT cord-254317-n2knqj4z 298 11 mean mean JJ cord-254317-n2knqj4z 298 12 significant significant JJ cord-254317-n2knqj4z 298 13 difference difference NN cord-254317-n2knqj4z 298 14 between between IN cord-254317-n2knqj4z 298 15 groups group NNS cord-254317-n2knqj4z 298 16 ( ( -LRB- cord-254317-n2knqj4z 298 17 P p NN cord-254317-n2knqj4z 298 18 < < XX cord-254317-n2knqj4z 298 19 0.05 0.05 CD cord-254317-n2knqj4z 298 20 ) ) -RRB- cord-254317-n2knqj4z 298 21 . . . cord-254317-n2knqj4z 298 22 ' ' '' cord-254317-n2knqj4z 298 23 - - : cord-254317-n2knqj4z 298 24 ' ' '' cord-254317-n2knqj4z 298 25 , , , cord-254317-n2knqj4z 298 26 not not RB cord-254317-n2knqj4z 298 27 detected detect VBN cord-254317-n2knqj4z 298 28 . . . cord-254317-n2knqj4z 299 1 Y. Y. NNP cord-254317-n2knqj4z 299 2 Su Su NNP cord-254317-n2knqj4z 299 3 et et FW cord-254317-n2knqj4z 299 4 al al NNP cord-254317-n2knqj4z 299 5 . . . cord-254317-n2knqj4z 300 1 Veterinary Veterinary NNP cord-254317-n2knqj4z 300 2 Microbiology Microbiology NNP cord-254317-n2knqj4z 300 3 228 228 CD cord-254317-n2knqj4z 300 4 ( ( -LRB- cord-254317-n2knqj4z 300 5 2019 2019 CD cord-254317-n2knqj4z 300 6 ) ) -RRB- cord-254317-n2knqj4z 300 7 202 202 CD cord-254317-n2knqj4z 300 8 - - SYM cord-254317-n2knqj4z 300 9 212 212 CD cord-254317-n2knqj4z 300 10 at at IN cord-254317-n2knqj4z 300 11 the the DT cord-254317-n2knqj4z 300 12 tested test VBN cord-254317-n2knqj4z 300 13 concentrations concentration NNS cord-254317-n2knqj4z 300 14 had have VBD cord-254317-n2knqj4z 300 15 no no DT cord-254317-n2knqj4z 300 16 effects effect NNS cord-254317-n2knqj4z 300 17 on on IN cord-254317-n2knqj4z 300 18 the the DT cord-254317-n2knqj4z 300 19 infection infection NN cord-254317-n2knqj4z 300 20 of of IN cord-254317-n2knqj4z 300 21 icPC22 icpc22 NN cord-254317-n2knqj4z 301 1 A a LS cord-254317-n2knqj4z 301 2 - - HYPH cord-254317-n2knqj4z 301 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 301 4 ( ( -LRB- cord-254317-n2knqj4z 301 5 Fig Fig NNP cord-254317-n2knqj4z 301 6 . . . cord-254317-n2knqj4z 301 7 6B 6b CD cord-254317-n2knqj4z 301 8 - - HYPH cord-254317-n2knqj4z 301 9 E E NNP cord-254317-n2knqj4z 301 10 ) ) -RRB- cord-254317-n2knqj4z 301 11 . . . cord-254317-n2knqj4z 302 1 Similarly similarly RB cord-254317-n2knqj4z 302 2 , , , cord-254317-n2knqj4z 302 3 in in IN cord-254317-n2knqj4z 302 4 IPEC IPEC NNP cord-254317-n2knqj4z 302 5 - - HYPH cord-254317-n2knqj4z 302 6 DQ dq NN cord-254317-n2knqj4z 302 7 cells cell NNS cord-254317-n2knqj4z 302 8 , , , cord-254317-n2knqj4z 302 9 the the DT cord-254317-n2knqj4z 302 10 infectivity infectivity NN cord-254317-n2knqj4z 302 11 of of IN cord-254317-n2knqj4z 302 12 icPC22A icPC22A NNP cord-254317-n2knqj4z 302 13 was be VBD cord-254317-n2knqj4z 302 14 increased increase VBN cord-254317-n2knqj4z 302 15 significantly significantly RB cord-254317-n2knqj4z 302 16 by by IN cord-254317-n2knqj4z 302 17 0.1 0.1 CD cord-254317-n2knqj4z 302 18 - - HYPH cord-254317-n2knqj4z 302 19 0.3 0.3 CD cord-254317-n2knqj4z 302 20 % % NN cord-254317-n2knqj4z 302 21 bile bile NN cord-254317-n2knqj4z 302 22 but but CC cord-254317-n2knqj4z 302 23 was be VBD cord-254317-n2knqj4z 302 24 decreased decrease VBN cord-254317-n2knqj4z 302 25 significantly significantly RB cord-254317-n2knqj4z 302 26 by by IN cord-254317-n2knqj4z 302 27 the the DT cord-254317-n2knqj4z 302 28 concentration concentration NN cord-254317-n2knqj4z 302 29 of of IN cord-254317-n2knqj4z 302 30 1.0 1.0 CD cord-254317-n2knqj4z 302 31 % % NN cord-254317-n2knqj4z 302 32 ( ( -LRB- cord-254317-n2knqj4z 302 33 Fig Fig NNP cord-254317-n2knqj4z 302 34 . . . cord-254317-n2knqj4z 302 35 6F 6F NNP cord-254317-n2knqj4z 302 36 ) ) -RRB- cord-254317-n2knqj4z 302 37 . . . cord-254317-n2knqj4z 303 1 However however RB cord-254317-n2knqj4z 303 2 , , , cord-254317-n2knqj4z 303 3 0.1 0.1 CD cord-254317-n2knqj4z 303 4 - - SYM cord-254317-n2knqj4z 303 5 1.0 1.0 CD cord-254317-n2knqj4z 303 6 % % NN cord-254317-n2knqj4z 303 7 bile bile NN cord-254317-n2knqj4z 303 8 decreased decrease VBD cord-254317-n2knqj4z 303 9 the the DT cord-254317-n2knqj4z 303 10 infectivity infectivity NN cord-254317-n2knqj4z 303 11 of of IN cord-254317-n2knqj4z 303 12 icPC22A icPC22A NNP cord-254317-n2knqj4z 303 13 - - HYPH cord-254317-n2knqj4z 303 14 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 303 15 significantly significantly RB cord-254317-n2knqj4z 303 16 . . . cord-254317-n2knqj4z 304 1 Bile bile NN cord-254317-n2knqj4z 304 2 acids acid NNS cord-254317-n2knqj4z 304 3 GCDCA GCDCA NNP cord-254317-n2knqj4z 305 1 ( ( -LRB- cord-254317-n2knqj4z 305 2 Fig Fig NNP cord-254317-n2knqj4z 305 3 . . . cord-254317-n2knqj4z 305 4 6G 6G NNP cord-254317-n2knqj4z 305 5 - - HYPH cord-254317-n2knqj4z 305 6 J J NNP cord-254317-n2knqj4z 305 7 ) ) -RRB- cord-254317-n2knqj4z 305 8 . . . cord-254317-n2knqj4z 306 1 No no DT cord-254317-n2knqj4z 306 2 significant significant JJ cord-254317-n2knqj4z 306 3 effects effect NNS cord-254317-n2knqj4z 306 4 of of IN cord-254317-n2knqj4z 306 5 bile bile NN cord-254317-n2knqj4z 306 6 acids acid NNS cord-254317-n2knqj4z 306 7 on on IN cord-254317-n2knqj4z 306 8 icPC22A icPC22A NNP cord-254317-n2knqj4z 306 9 - - HYPH cord-254317-n2knqj4z 306 10 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 306 11 were be VBD cord-254317-n2knqj4z 306 12 observed observe VBN cord-254317-n2knqj4z 306 13 except except IN cord-254317-n2knqj4z 306 14 for for IN cord-254317-n2knqj4z 306 15 that that DT cord-254317-n2knqj4z 306 16 the the DT cord-254317-n2knqj4z 306 17 highest high JJS cord-254317-n2knqj4z 306 18 concentration concentration NN cord-254317-n2knqj4z 306 19 ( ( -LRB- cord-254317-n2knqj4z 306 20 200 200 CD cord-254317-n2knqj4z 306 21 μM μM NNP cord-254317-n2knqj4z 306 22 ) ) -RRB- cord-254317-n2knqj4z 306 23 of of IN cord-254317-n2knqj4z 306 24 GCDCA GCDCA NNP cord-254317-n2knqj4z 306 25 and and CC cord-254317-n2knqj4z 306 26 DCA DCA NNP cord-254317-n2knqj4z 306 27 decreased decrease VBD cord-254317-n2knqj4z 306 28 its -PRON- PRP$ cord-254317-n2knqj4z 306 29 infectivity infectivity NN cord-254317-n2knqj4z 306 30 significantly significantly RB cord-254317-n2knqj4z 306 31 ( ( -LRB- cord-254317-n2knqj4z 306 32 Fig Fig NNP cord-254317-n2knqj4z 306 33 . . . cord-254317-n2knqj4z 306 34 6G 6G NNP cord-254317-n2knqj4z 306 35 - - HYPH cord-254317-n2knqj4z 306 36 J J NNP cord-254317-n2knqj4z 306 37 ) ) -RRB- cord-254317-n2knqj4z 306 38 . . . cord-254317-n2knqj4z 307 1 Fig Fig NNP cord-254317-n2knqj4z 307 2 . . . cord-254317-n2knqj4z 308 1 2 2 LS cord-254317-n2knqj4z 308 2 . . . cord-254317-n2knqj4z 309 1 Histopathological Histopathological NNP cord-254317-n2knqj4z 309 2 examination examination NN cord-254317-n2knqj4z 309 3 of of IN cord-254317-n2knqj4z 309 4 the the DT cord-254317-n2knqj4z 309 5 Gn Gn NNP cord-254317-n2knqj4z 309 6 piglets piglet NNS cord-254317-n2knqj4z 309 7 infected infect VBN cord-254317-n2knqj4z 309 8 with with IN cord-254317-n2knqj4z 309 9 individual individual NN cord-254317-n2knqj4z 309 10 or or CC cord-254317-n2knqj4z 309 11 both both DT cord-254317-n2knqj4z 309 12 icPC22A icPC22A NNP cord-254317-n2knqj4z 309 13 and and CC cord-254317-n2knqj4z 309 14 icPC22A icPC22A NNP cord-254317-n2knqj4z 309 15 - - HYPH cord-254317-n2knqj4z 309 16 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 309 17 . . . cord-254317-n2knqj4z 310 1 ( ( -LRB- cord-254317-n2knqj4z 310 2 A a DT cord-254317-n2knqj4z 310 3 ) ) -RRB- cord-254317-n2knqj4z 310 4 IHC IHC NNP cord-254317-n2knqj4z 310 5 staining staining NN cord-254317-n2knqj4z 310 6 of of IN cord-254317-n2knqj4z 310 7 PEDV PEDV NNP cord-254317-n2knqj4z 310 8 N n CD cord-254317-n2knqj4z 310 9 proteins protein NNS cord-254317-n2knqj4z 310 10 in in IN cord-254317-n2knqj4z 310 11 the the DT cord-254317-n2knqj4z 310 12 jejunal jejunal JJ cord-254317-n2knqj4z 310 13 and and CC cord-254317-n2knqj4z 310 14 ileal ileal JJ cord-254317-n2knqj4z 310 15 sections section NNS cord-254317-n2knqj4z 310 16 of of IN cord-254317-n2knqj4z 310 17 piglets piglet NNS cord-254317-n2knqj4z 310 18 that that WDT cord-254317-n2knqj4z 310 19 died die VBD cord-254317-n2knqj4z 310 20 or or CC cord-254317-n2knqj4z 310 21 were be VBD cord-254317-n2knqj4z 310 22 euthanized euthanize VBN cord-254317-n2knqj4z 310 23 at at IN cord-254317-n2knqj4z 310 24 2 2 CD cord-254317-n2knqj4z 310 25 - - SYM cord-254317-n2knqj4z 310 26 3 3 CD cord-254317-n2knqj4z 310 27 dpi dpi NN cord-254317-n2knqj4z 310 28 ( ( -LRB- cord-254317-n2knqj4z 310 29 magnification magnification NN cord-254317-n2knqj4z 310 30 , , , cord-254317-n2knqj4z 310 31 200× 200× CD cord-254317-n2knqj4z 310 32 ) ) -RRB- cord-254317-n2knqj4z 310 33 . . . cord-254317-n2knqj4z 311 1 The the DT cord-254317-n2knqj4z 311 2 brown brown JJ cord-254317-n2knqj4z 311 3 signals signal NNS cord-254317-n2knqj4z 311 4 represented represent VBD cord-254317-n2knqj4z 311 5 the the DT cord-254317-n2knqj4z 311 6 PEDV PEDV NNP cord-254317-n2knqj4z 311 7 N N NNP cord-254317-n2knqj4z 311 8 antigens antigen NNS cord-254317-n2knqj4z 311 9 in in IN cord-254317-n2knqj4z 311 10 enterocytes enterocyte NNS cord-254317-n2knqj4z 311 11 . . . cord-254317-n2knqj4z 312 1 ( ( -LRB- cord-254317-n2knqj4z 312 2 B b NN cord-254317-n2knqj4z 312 3 ) ) -RRB- cord-254317-n2knqj4z 312 4 Villous Villous NNP cord-254317-n2knqj4z 312 5 height height NN cord-254317-n2knqj4z 312 6 to to IN cord-254317-n2knqj4z 312 7 crypt crypt NN cord-254317-n2knqj4z 312 8 depth depth NN cord-254317-n2knqj4z 313 1 ( ( -LRB- cord-254317-n2knqj4z 313 2 VH VH NNP cord-254317-n2knqj4z 313 3 / / SYM cord-254317-n2knqj4z 313 4 CD CD NNP cord-254317-n2knqj4z 313 5 ) ) -RRB- cord-254317-n2knqj4z 313 6 ratios ratio NNS cord-254317-n2knqj4z 313 7 of of IN cord-254317-n2knqj4z 313 8 jejunum jejunum NNS cord-254317-n2knqj4z 313 9 and and CC cord-254317-n2knqj4z 313 10 ileum ileum NN cord-254317-n2knqj4z 313 11 of of IN cord-254317-n2knqj4z 313 12 the the DT cord-254317-n2knqj4z 313 13 Gn Gn NNP cord-254317-n2knqj4z 313 14 piglets piglet NNS cord-254317-n2knqj4z 313 15 euthanized euthanize VBN cord-254317-n2knqj4z 313 16 at at IN cord-254317-n2knqj4z 313 17 2 2 CD cord-254317-n2knqj4z 313 18 - - SYM cord-254317-n2knqj4z 313 19 3 3 CD cord-254317-n2knqj4z 313 20 dpi dpi NN cord-254317-n2knqj4z 313 21 . . . cord-254317-n2knqj4z 314 1 For for IN cord-254317-n2knqj4z 314 2 each each DT cord-254317-n2knqj4z 314 3 intestinal intestinal JJ cord-254317-n2knqj4z 314 4 section section NN cord-254317-n2knqj4z 314 5 , , , cord-254317-n2knqj4z 314 6 10 10 CD cord-254317-n2knqj4z 314 7 villi villus NNS cord-254317-n2knqj4z 314 8 and and CC cord-254317-n2knqj4z 314 9 crypts crypt NNS cord-254317-n2knqj4z 314 10 were be VBD cord-254317-n2knqj4z 314 11 measured measure VBN cord-254317-n2knqj4z 314 12 . . . cord-254317-n2knqj4z 315 1 Data datum NNS cord-254317-n2knqj4z 315 2 are be VBP cord-254317-n2knqj4z 315 3 shown show VBN cord-254317-n2knqj4z 315 4 as as IN cord-254317-n2knqj4z 315 5 the the DT cord-254317-n2knqj4z 315 6 M M NNP cord-254317-n2knqj4z 315 7 ± ± NNP cord-254317-n2knqj4z 315 8 SD SD NNP cord-254317-n2knqj4z 315 9 . . . cord-254317-n2knqj4z 316 1 Number number NN cord-254317-n2knqj4z 316 2 of of IN cord-254317-n2knqj4z 316 3 asterisks asterisk NNS cord-254317-n2knqj4z 316 4 indicate indicate VBP cord-254317-n2knqj4z 316 5 significant significant JJ cord-254317-n2knqj4z 316 6 difference difference NN cord-254317-n2knqj4z 316 7 between between IN cord-254317-n2knqj4z 316 8 groups group NNS cord-254317-n2knqj4z 316 9 ( ( -LRB- cord-254317-n2knqj4z 316 10 * * NFP cord-254317-n2knqj4z 316 11 , , , cord-254317-n2knqj4z 316 12 p p NN cord-254317-n2knqj4z 316 13 < < XX cord-254317-n2knqj4z 316 14 0.05 0.05 CD cord-254317-n2knqj4z 316 15 ; ; : cord-254317-n2knqj4z 317 1 * * NFP cord-254317-n2knqj4z 317 2 * * NFP cord-254317-n2knqj4z 317 3 , , , cord-254317-n2knqj4z 317 4 P p NN cord-254317-n2knqj4z 317 5 < < XX cord-254317-n2knqj4z 317 6 0.01 0.01 CD cord-254317-n2knqj4z 317 7 ; ; : cord-254317-n2knqj4z 318 1 * * NFP cord-254317-n2knqj4z 318 2 * * NFP cord-254317-n2knqj4z 318 3 * * NFP cord-254317-n2knqj4z 318 4 , , , cord-254317-n2knqj4z 318 5 P p NN cord-254317-n2knqj4z 318 6 < < XX cord-254317-n2knqj4z 318 7 0.001 0.001 CD cord-254317-n2knqj4z 318 8 ) ) -RRB- cord-254317-n2knqj4z 318 9 . . . cord-254317-n2knqj4z 318 10 ' ' '' cord-254317-n2knqj4z 318 11 ns ns IN cord-254317-n2knqj4z 318 12 ' ' '' cord-254317-n2knqj4z 318 13 , , , cord-254317-n2knqj4z 318 14 not not RB cord-254317-n2knqj4z 318 15 significant significant JJ cord-254317-n2knqj4z 318 16 . . . cord-254317-n2knqj4z 319 1 ( ( -LRB- cord-254317-n2knqj4z 319 2 C C NNP cord-254317-n2knqj4z 319 3 ) ) -RRB- cord-254317-n2knqj4z 319 4 IF if IN cord-254317-n2knqj4z 319 5 staining staining NN cord-254317-n2knqj4z 319 6 of of IN cord-254317-n2knqj4z 319 7 PEDV PEDV NNP cord-254317-n2knqj4z 319 8 S S NNP cord-254317-n2knqj4z 319 9 proteins protein NNS cord-254317-n2knqj4z 319 10 in in IN cord-254317-n2knqj4z 319 11 the the DT cord-254317-n2knqj4z 319 12 jejunal jejunal JJ cord-254317-n2knqj4z 319 13 sections section NNS cord-254317-n2knqj4z 319 14 of of IN cord-254317-n2knqj4z 319 15 piglets piglet NNS cord-254317-n2knqj4z 319 16 that that WDT cord-254317-n2knqj4z 319 17 died die VBD cord-254317-n2knqj4z 319 18 or or CC cord-254317-n2knqj4z 319 19 were be VBD cord-254317-n2knqj4z 319 20 euthanized euthanize VBN cord-254317-n2knqj4z 319 21 at at IN cord-254317-n2knqj4z 319 22 2 2 CD cord-254317-n2knqj4z 319 23 - - SYM cord-254317-n2knqj4z 319 24 3 3 CD cord-254317-n2knqj4z 319 25 dpi dpi NN cord-254317-n2knqj4z 319 26 ( ( -LRB- cord-254317-n2knqj4z 319 27 magnification magnification NN cord-254317-n2knqj4z 319 28 , , , cord-254317-n2knqj4z 319 29 200 200 CD cord-254317-n2knqj4z 319 30 x x SYM cord-254317-n2knqj4z 319 31 ) ) -RRB- cord-254317-n2knqj4z 319 32 . . . cord-254317-n2knqj4z 320 1 Tissue tissue NN cord-254317-n2knqj4z 320 2 sections section NNS cord-254317-n2knqj4z 320 3 were be VBD cord-254317-n2knqj4z 320 4 stained stain VBN cord-254317-n2knqj4z 320 5 for for IN cord-254317-n2knqj4z 320 6 the the DT cord-254317-n2knqj4z 320 7 detection detection NN cord-254317-n2knqj4z 320 8 of of IN cord-254317-n2knqj4z 320 9 icPC22A icPC22A NNP cord-254317-n2knqj4z 320 10 and and CC cord-254317-n2knqj4z 320 11 icPC22A icPC22A NNP cord-254317-n2knqj4z 320 12 - - HYPH cord-254317-n2knqj4z 320 13 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 320 14 antigens antigen NNS cord-254317-n2knqj4z 320 15 targeting target VBG cord-254317-n2knqj4z 320 16 the the DT cord-254317-n2knqj4z 320 17 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 320 18 protein protein NN cord-254317-n2knqj4z 320 19 ( ( -LRB- cord-254317-n2knqj4z 320 20 green green NNP cord-254317-n2knqj4z 320 21 ) ) -RRB- cord-254317-n2knqj4z 320 22 , , , cord-254317-n2knqj4z 320 23 and and CC cord-254317-n2knqj4z 320 24 for for IN cord-254317-n2knqj4z 320 25 icPC22A icPC22A NNP cord-254317-n2knqj4z 320 26 antigens antigen NNS cord-254317-n2knqj4z 320 27 targeting target VBG cord-254317-n2knqj4z 320 28 the the DT cord-254317-n2knqj4z 320 29 S1 s1 NN cord-254317-n2knqj4z 320 30 ° ° NN cord-254317-n2knqj4z 320 31 domain domain NN cord-254317-n2knqj4z 320 32 ( ( -LRB- cord-254317-n2knqj4z 320 33 red red NNP cord-254317-n2knqj4z 320 34 ) ) -RRB- cord-254317-n2knqj4z 320 35 , , , cord-254317-n2knqj4z 320 36 and and CC cord-254317-n2knqj4z 320 37 counterstained counterstaine VBN cord-254317-n2knqj4z 320 38 for for IN cord-254317-n2knqj4z 320 39 cell cell NN cord-254317-n2knqj4z 320 40 nuclei nucleus NNS cord-254317-n2knqj4z 320 41 ( ( -LRB- cord-254317-n2knqj4z 320 42 blue blue JJ cord-254317-n2knqj4z 320 43 ) ) -RRB- cord-254317-n2knqj4z 320 44 . . . cord-254317-n2knqj4z 321 1 In in IN cord-254317-n2knqj4z 321 2 the the DT cord-254317-n2knqj4z 321 3 merged merge VBN cord-254317-n2knqj4z 321 4 images image NNS cord-254317-n2knqj4z 321 5 , , , cord-254317-n2knqj4z 321 6 yellow yellow JJ cord-254317-n2knqj4z 321 7 dots dot NNS cord-254317-n2knqj4z 321 8 represented represent VBD cord-254317-n2knqj4z 321 9 icPC22A icPC22A NNP cord-254317-n2knqj4z 321 10 - - HYPH cord-254317-n2knqj4z 321 11 infected infect VBN cord-254317-n2knqj4z 321 12 ( ( -LRB- cord-254317-n2knqj4z 321 13 or or CC cord-254317-n2knqj4z 321 14 co co JJ cord-254317-n2knqj4z 321 15 - - JJ cord-254317-n2knqj4z 321 16 infected infect VBN cord-254317-n2knqj4z 321 17 in in IN cord-254317-n2knqj4z 321 18 coinfection coinfection NN cord-254317-n2knqj4z 321 19 group group NN cord-254317-n2knqj4z 321 20 ) ) -RRB- cord-254317-n2knqj4z 321 21 cells cell NNS cord-254317-n2knqj4z 321 22 ( ( -LRB- cord-254317-n2knqj4z 321 23 merged merge VBN cord-254317-n2knqj4z 321 24 from from IN cord-254317-n2knqj4z 321 25 red red JJ cord-254317-n2knqj4z 321 26 and and CC cord-254317-n2knqj4z 321 27 green green JJ cord-254317-n2knqj4z 321 28 ) ) -RRB- cord-254317-n2knqj4z 321 29 and and CC cord-254317-n2knqj4z 321 30 the the DT cord-254317-n2knqj4z 321 31 green green JJ cord-254317-n2knqj4z 321 32 dots dot NNS cord-254317-n2knqj4z 321 33 represented represent VBD cord-254317-n2knqj4z 321 34 icPC22A icPC22A NNP cord-254317-n2knqj4z 321 35 - - HYPH cord-254317-n2knqj4z 321 36 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 321 37 infection infection NN cord-254317-n2knqj4z 321 38 alone alone RB cord-254317-n2knqj4z 321 39 . . . cord-254317-n2knqj4z 322 1 ( ( -LRB- cord-254317-n2knqj4z 322 2 magnification magnification NN cord-254317-n2knqj4z 322 3 , , , cord-254317-n2knqj4z 322 4 200 200 CD cord-254317-n2knqj4z 322 5 x x SYM cord-254317-n2knqj4z 322 6 ) ) -RRB- cord-254317-n2knqj4z 322 7 . . . cord-254317-n2knqj4z 323 1 Cells cell NNS cord-254317-n2knqj4z 323 2 were be VBD cord-254317-n2knqj4z 323 3 stained stain VBN cord-254317-n2knqj4z 323 4 for for IN cord-254317-n2knqj4z 323 5 the the DT cord-254317-n2knqj4z 323 6 detection detection NN cord-254317-n2knqj4z 323 7 of of IN cord-254317-n2knqj4z 323 8 icPC22A icPC22A NNP cord-254317-n2knqj4z 323 9 and and CC cord-254317-n2knqj4z 323 10 icPC22 icpc22 NN cord-254317-n2knqj4z 324 1 A a LS cord-254317-n2knqj4z 324 2 - - HYPH cord-254317-n2knqj4z 324 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 324 4 antigens antigen NNS cord-254317-n2knqj4z 324 5 targeting target VBG cord-254317-n2knqj4z 324 6 the the DT cord-254317-n2knqj4z 324 7 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 324 8 protein protein NN cord-254317-n2knqj4z 324 9 ( ( -LRB- cord-254317-n2knqj4z 324 10 green green NNP cord-254317-n2knqj4z 324 11 ) ) -RRB- cord-254317-n2knqj4z 324 12 , , , cord-254317-n2knqj4z 324 13 and and CC cord-254317-n2knqj4z 324 14 for for IN cord-254317-n2knqj4z 324 15 icPC22A icPC22A NNP cord-254317-n2knqj4z 324 16 antigens antigen NNS cord-254317-n2knqj4z 324 17 targeting target VBG cord-254317-n2knqj4z 324 18 the the DT cord-254317-n2knqj4z 324 19 S1 s1 NN cord-254317-n2knqj4z 324 20 ° ° NN cord-254317-n2knqj4z 324 21 domain domain NN cord-254317-n2knqj4z 324 22 ( ( -LRB- cord-254317-n2knqj4z 324 23 red red NNP cord-254317-n2knqj4z 324 24 ) ) -RRB- cord-254317-n2knqj4z 324 25 , , , cord-254317-n2knqj4z 324 26 and and CC cord-254317-n2knqj4z 324 27 counterstained counterstaine VBN cord-254317-n2knqj4z 324 28 for for IN cord-254317-n2knqj4z 324 29 cell cell NN cord-254317-n2knqj4z 324 30 nuclei nucleus NNS cord-254317-n2knqj4z 324 31 ( ( -LRB- cord-254317-n2knqj4z 324 32 blue blue JJ cord-254317-n2knqj4z 324 33 ) ) -RRB- cord-254317-n2knqj4z 324 34 . . . cord-254317-n2knqj4z 325 1 In in IN cord-254317-n2knqj4z 325 2 the the DT cord-254317-n2knqj4z 325 3 merged merge VBN cord-254317-n2knqj4z 325 4 images image NNS cord-254317-n2knqj4z 325 5 , , , cord-254317-n2knqj4z 325 6 yellow yellow JJ cord-254317-n2knqj4z 325 7 dots dot NNS cord-254317-n2knqj4z 325 8 represented represent VBN cord-254317-n2knqj4z 326 1 icPC22A icpc22a PRP cord-254317-n2knqj4z 326 2 - - HYPH cord-254317-n2knqj4z 326 3 infected infect VBN cord-254317-n2knqj4z 326 4 ( ( -LRB- cord-254317-n2knqj4z 326 5 or or CC cord-254317-n2knqj4z 326 6 co co JJ cord-254317-n2knqj4z 326 7 - - JJ cord-254317-n2knqj4z 326 8 infected infect VBN cord-254317-n2knqj4z 326 9 in in IN cord-254317-n2knqj4z 326 10 coinfection coinfection NN cord-254317-n2knqj4z 326 11 condition condition NN cord-254317-n2knqj4z 326 12 ) ) -RRB- cord-254317-n2knqj4z 326 13 cells cell NNS cord-254317-n2knqj4z 326 14 and and CC cord-254317-n2knqj4z 326 15 the the DT cord-254317-n2knqj4z 326 16 green green JJ cord-254317-n2knqj4z 326 17 dots dot NNS cord-254317-n2knqj4z 326 18 represented represent VBD cord-254317-n2knqj4z 326 19 icPC22A icPC22A NNP cord-254317-n2knqj4z 326 20 - - HYPH cord-254317-n2knqj4z 326 21 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 326 22 infection infection NN cord-254317-n2knqj4z 326 23 alone alone RB cord-254317-n2knqj4z 326 24 . . . cord-254317-n2knqj4z 327 1 The the DT cord-254317-n2knqj4z 327 2 experimental experimental JJ cord-254317-n2knqj4z 327 3 data datum NNS cord-254317-n2knqj4z 327 4 were be VBD cord-254317-n2knqj4z 327 5 analyzed analyze VBN cord-254317-n2knqj4z 327 6 by by IN cord-254317-n2knqj4z 327 7 Student`s student`s NN cord-254317-n2knqj4z 327 8 t t NN cord-254317-n2knqj4z 327 9 - - HYPH cord-254317-n2knqj4z 327 10 test test NN cord-254317-n2knqj4z 327 11 . . . cord-254317-n2knqj4z 328 1 Letters letter NNS cord-254317-n2knqj4z 328 2 ' ' POS cord-254317-n2knqj4z 328 3 A A NNP cord-254317-n2knqj4z 328 4 , , , cord-254317-n2knqj4z 328 5 B B NNP cord-254317-n2knqj4z 328 6 and and CC cord-254317-n2knqj4z 328 7 C C NNP cord-254317-n2knqj4z 328 8 ' ' '' cord-254317-n2knqj4z 328 9 indicate indicate VBP cord-254317-n2knqj4z 328 10 a a DT cord-254317-n2knqj4z 328 11 mean mean JJ cord-254317-n2knqj4z 328 12 significant significant JJ cord-254317-n2knqj4z 328 13 difference difference NN cord-254317-n2knqj4z 328 14 between between IN cord-254317-n2knqj4z 328 15 groups group NNS cord-254317-n2knqj4z 328 16 ( ( -LRB- cord-254317-n2knqj4z 328 17 P p NN cord-254317-n2knqj4z 328 18 < < XX cord-254317-n2knqj4z 328 19 0.05 0.05 CD cord-254317-n2knqj4z 328 20 ) ) -RRB- cord-254317-n2knqj4z 328 21 . . . cord-254317-n2knqj4z 329 1 Previously previously RB cord-254317-n2knqj4z 329 2 , , , cord-254317-n2knqj4z 329 3 our -PRON- PRP$ cord-254317-n2knqj4z 329 4 laboratory laboratory NN cord-254317-n2knqj4z 329 5 isolated isolate VBD cord-254317-n2knqj4z 329 6 the the DT cord-254317-n2knqj4z 329 7 first first JJ cord-254317-n2knqj4z 329 8 S1 S1 NNP cord-254317-n2knqj4z 329 9 NTD NTD NNP cord-254317-n2knqj4z 329 10 - - HYPH cord-254317-n2knqj4z 329 11 del del NNP cord-254317-n2knqj4z 329 12 PEDV PEDV NNP cord-254317-n2knqj4z 329 13 strain strain NN cord-254317-n2knqj4z 329 14 , , , cord-254317-n2knqj4z 329 15 PC177 pc177 CD cord-254317-n2knqj4z 329 16 , , , cord-254317-n2knqj4z 329 17 from from IN cord-254317-n2knqj4z 329 18 Vero Vero NNP cord-254317-n2knqj4z 329 19 cell cell NN cord-254317-n2knqj4z 329 20 culture culture NN cord-254317-n2knqj4z 330 1 ( ( -LRB- cord-254317-n2knqj4z 330 2 Oka Oka NNP cord-254317-n2knqj4z 330 3 et et NNP cord-254317-n2knqj4z 330 4 al al NNP cord-254317-n2knqj4z 330 5 . . NNP cord-254317-n2knqj4z 330 6 , , , cord-254317-n2knqj4z 330 7 2014 2014 CD cord-254317-n2knqj4z 330 8 ) ) -RRB- cord-254317-n2knqj4z 330 9 . . . cord-254317-n2knqj4z 331 1 Recent recent JJ cord-254317-n2knqj4z 331 2 studies study NNS cord-254317-n2knqj4z 331 3 revealed reveal VBD cord-254317-n2knqj4z 331 4 that that IN cord-254317-n2knqj4z 331 5 S1 S1 NNP cord-254317-n2knqj4z 331 6 NTD NTD NNP cord-254317-n2knqj4z 331 7 - - HYPH cord-254317-n2knqj4z 331 8 del del NNP cord-254317-n2knqj4z 331 9 PEDVs pedv NNS cord-254317-n2knqj4z 331 10 naturally naturally RB cord-254317-n2knqj4z 331 11 evolved evolve VBD cord-254317-n2knqj4z 331 12 in in IN cord-254317-n2knqj4z 331 13 the the DT cord-254317-n2knqj4z 331 14 field field NN cord-254317-n2knqj4z 331 15 and and CC cord-254317-n2knqj4z 331 16 often often RB cord-254317-n2knqj4z 331 17 coinfected coinfecte VBD cord-254317-n2knqj4z 331 18 pigs pig NNS cord-254317-n2knqj4z 331 19 with with IN cord-254317-n2knqj4z 331 20 the the DT cord-254317-n2knqj4z 331 21 S s NN cord-254317-n2knqj4z 331 22 - - HYPH cord-254317-n2knqj4z 331 23 intact intact JJ cord-254317-n2knqj4z 331 24 PEDV PEDV NNP cord-254317-n2knqj4z 331 25 ( ( -LRB- cord-254317-n2knqj4z 331 26 Suzuki Suzuki NNP cord-254317-n2knqj4z 331 27 et et FW cord-254317-n2knqj4z 331 28 al al NNP cord-254317-n2knqj4z 331 29 . . NNP cord-254317-n2knqj4z 331 30 , , , cord-254317-n2knqj4z 331 31 2015 2015 CD cord-254317-n2knqj4z 331 32 ; ; : cord-254317-n2knqj4z 331 33 Diep Diep NNP cord-254317-n2knqj4z 331 34 et et FW cord-254317-n2knqj4z 331 35 al al NNP cord-254317-n2knqj4z 331 36 . . NNP cord-254317-n2knqj4z 331 37 , , , cord-254317-n2knqj4z 331 38 2017 2017 CD cord-254317-n2knqj4z 331 39 ; ; : cord-254317-n2knqj4z 331 40 Zhang Zhang NNP cord-254317-n2knqj4z 331 41 et et NNP cord-254317-n2knqj4z 331 42 al al NNP cord-254317-n2knqj4z 331 43 . . . cord-254317-n2knqj4z 332 1 , , , cord-254317-n2knqj4z 332 2 2018a 2018a CD cord-254317-n2knqj4z 332 3 ; ; : cord-254317-n2knqj4z 332 4 Su Su NNP cord-254317-n2knqj4z 332 5 et et FW cord-254317-n2knqj4z 332 6 al al NNP cord-254317-n2knqj4z 332 7 . . NNP cord-254317-n2knqj4z 332 8 , , , cord-254317-n2knqj4z 332 9 2018 2018 CD cord-254317-n2knqj4z 332 10 ) ) -RRB- cord-254317-n2knqj4z 332 11 . . . cord-254317-n2knqj4z 333 1 The the DT cord-254317-n2knqj4z 333 2 S1 S1 NNP cord-254317-n2knqj4z 333 3 NTD NTD NNP cord-254317-n2knqj4z 333 4 - - HYPH cord-254317-n2knqj4z 333 5 del del NNP cord-254317-n2knqj4z 333 6 PEDV PEDV NNP cord-254317-n2knqj4z 333 7 had have VBD cord-254317-n2knqj4z 333 8 no no DT cord-254317-n2knqj4z 333 9 tissue tissue NN cord-254317-n2knqj4z 333 10 tropism tropism NN cord-254317-n2knqj4z 333 11 change change NN cord-254317-n2knqj4z 333 12 compared compare VBN cord-254317-n2knqj4z 333 13 with with IN cord-254317-n2knqj4z 333 14 the the DT cord-254317-n2knqj4z 333 15 S s NN cord-254317-n2knqj4z 333 16 - - HYPH cord-254317-n2knqj4z 333 17 intact intact JJ cord-254317-n2knqj4z 333 18 PEDV PEDV NNP cord-254317-n2knqj4z 333 19 ( ( -LRB- cord-254317-n2knqj4z 333 20 Suzuki Suzuki NNP cord-254317-n2knqj4z 333 21 et et FW cord-254317-n2knqj4z 333 22 al al NNP cord-254317-n2knqj4z 333 23 . . NNP cord-254317-n2knqj4z 333 24 , , , cord-254317-n2knqj4z 333 25 2016 2016 CD cord-254317-n2knqj4z 333 26 ; ; : cord-254317-n2knqj4z 333 27 Hou Hou NNP cord-254317-n2knqj4z 333 28 et et NNP cord-254317-n2knqj4z 333 29 al al NNP cord-254317-n2knqj4z 333 30 . . NNP cord-254317-n2knqj4z 333 31 , , , cord-254317-n2knqj4z 333 32 2017 2017 CD cord-254317-n2knqj4z 333 33 ) ) -RRB- cord-254317-n2knqj4z 333 34 . . . cord-254317-n2knqj4z 334 1 This this DT cord-254317-n2knqj4z 334 2 differs differ VBZ cord-254317-n2knqj4z 334 3 from from IN cord-254317-n2knqj4z 334 4 porcine porcine JJ cord-254317-n2knqj4z 334 5 respiratory respiratory JJ cord-254317-n2knqj4z 334 6 coronavirus coronavirus NN cord-254317-n2knqj4z 334 7 ( ( -LRB- cord-254317-n2knqj4z 334 8 PRCV PRCV NNP cord-254317-n2knqj4z 334 9 ) ) -RRB- cord-254317-n2knqj4z 334 10 that that WDT cord-254317-n2knqj4z 334 11 is be VBZ cord-254317-n2knqj4z 334 12 a a DT cord-254317-n2knqj4z 334 13 S1 S1 NNP cord-254317-n2knqj4z 334 14 NTD NTD NNP cord-254317-n2knqj4z 334 15 - - HYPH cord-254317-n2knqj4z 334 16 del del NNP cord-254317-n2knqj4z 334 17 version version NN cord-254317-n2knqj4z 334 18 of of IN cord-254317-n2knqj4z 334 19 TGEV TGEV NNP cord-254317-n2knqj4z 334 20 and and CC cord-254317-n2knqj4z 334 21 changes change VBZ cord-254317-n2knqj4z 334 22 the the DT cord-254317-n2knqj4z 334 23 major major JJ cord-254317-n2knqj4z 334 24 tissue tissue NN cord-254317-n2knqj4z 334 25 tropism tropism NN cord-254317-n2knqj4z 334 26 from from IN cord-254317-n2knqj4z 334 27 intestines intestine NNS cord-254317-n2knqj4z 334 28 to to IN cord-254317-n2knqj4z 334 29 respiratory respiratory JJ cord-254317-n2knqj4z 334 30 tract tract NN cord-254317-n2knqj4z 334 31 ( ( -LRB- cord-254317-n2knqj4z 334 32 Zhang Zhang NNP cord-254317-n2knqj4z 334 33 et et NNP cord-254317-n2knqj4z 334 34 al al NNP cord-254317-n2knqj4z 334 35 . . NNP cord-254317-n2knqj4z 334 36 , , , cord-254317-n2knqj4z 334 37 2007 2007 CD cord-254317-n2knqj4z 334 38 ) ) -RRB- cord-254317-n2knqj4z 334 39 . . . cord-254317-n2knqj4z 335 1 In in IN cord-254317-n2knqj4z 335 2 this this DT cord-254317-n2knqj4z 335 3 study study NN cord-254317-n2knqj4z 335 4 , , , cord-254317-n2knqj4z 335 5 we -PRON- PRP cord-254317-n2knqj4z 335 6 investigated investigate VBD cord-254317-n2knqj4z 335 7 the the DT cord-254317-n2knqj4z 335 8 replication replication NN cord-254317-n2knqj4z 335 9 of of IN cord-254317-n2knqj4z 335 10 S1 S1 NNP cord-254317-n2knqj4z 335 11 NTD- NTD- NNP cord-254317-n2knqj4z 335 12 Fig Fig NNP cord-254317-n2knqj4z 335 13 . . . cord-254317-n2knqj4z 336 1 4 4 LS cord-254317-n2knqj4z 336 2 . . . cord-254317-n2knqj4z 337 1 Infection infection NN cord-254317-n2knqj4z 337 2 of of IN cord-254317-n2knqj4z 337 3 PEDV PEDV NNP cord-254317-n2knqj4z 337 4 icPC22A icPC22A NNP cord-254317-n2knqj4z 337 5 and and CC cord-254317-n2knqj4z 337 6 icPC22A icPC22A NNP cord-254317-n2knqj4z 337 7 - - HYPH cord-254317-n2knqj4z 337 8 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 338 1 in in IN cord-254317-n2knqj4z 338 2 neuraminidase neuraminidase NN cord-254317-n2knqj4z 338 3 ( ( -LRB- cord-254317-n2knqj4z 338 4 NA)-treated na)-treated CD cord-254317-n2knqj4z 338 5 Vero Vero NNP cord-254317-n2knqj4z 338 6 and and CC cord-254317-n2knqj4z 338 7 IPEC IPEC NNP cord-254317-n2knqj4z 338 8 - - HYPH cord-254317-n2knqj4z 338 9 DQ dq NN cord-254317-n2knqj4z 338 10 cells cell NNS cord-254317-n2knqj4z 338 11 . . . cord-254317-n2knqj4z 339 1 Vero Vero NNP cord-254317-n2knqj4z 339 2 or or CC cord-254317-n2knqj4z 339 3 IPEC IPEC NNP cord-254317-n2knqj4z 339 4 - - HYPH cord-254317-n2knqj4z 339 5 DQ dq NN cord-254317-n2knqj4z 339 6 cell cell NN cord-254317-n2knqj4z 339 7 monolayers monolayer NNS cord-254317-n2knqj4z 339 8 in in IN cord-254317-n2knqj4z 339 9 96-well 96-well CD cord-254317-n2knqj4z 339 10 plates plate NNS cord-254317-n2knqj4z 339 11 were be VBD cord-254317-n2knqj4z 339 12 treated treat VBN cord-254317-n2knqj4z 339 13 with with IN cord-254317-n2knqj4z 339 14 250 250 CD cord-254317-n2knqj4z 339 15 mU mU NNP cord-254317-n2knqj4z 339 16 NA NA NNP cord-254317-n2knqj4z 339 17 or or CC cord-254317-n2knqj4z 339 18 mock mock VB cord-254317-n2knqj4z 339 19 at at IN cord-254317-n2knqj4z 339 20 37 37 CD cord-254317-n2knqj4z 339 21 ℃ ℃ NNS cord-254317-n2knqj4z 339 22 for for IN cord-254317-n2knqj4z 339 23 2 2 CD cord-254317-n2knqj4z 339 24 h. h. NN cord-254317-n2knqj4z 340 1 After after IN cord-254317-n2knqj4z 340 2 three three CD cord-254317-n2knqj4z 340 3 washings washing NNS cord-254317-n2knqj4z 340 4 with with IN cord-254317-n2knqj4z 340 5 DMEM DMEM NNP cord-254317-n2knqj4z 340 6 / / SYM cord-254317-n2knqj4z 340 7 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 340 8 , , , cord-254317-n2knqj4z 340 9 cells cell NNS cord-254317-n2knqj4z 340 10 were be VBD cord-254317-n2knqj4z 340 11 inoculated inoculate VBN cord-254317-n2knqj4z 340 12 with with IN cord-254317-n2knqj4z 340 13 equal equal JJ cord-254317-n2knqj4z 340 14 amounts amount NNS cord-254317-n2knqj4z 340 15 of of IN cord-254317-n2knqj4z 340 16 virus virus NN cord-254317-n2knqj4z 340 17 at at IN cord-254317-n2knqj4z 340 18 a a DT cord-254317-n2knqj4z 340 19 MOI MOI NNP cord-254317-n2knqj4z 340 20 of of IN cord-254317-n2knqj4z 340 21 0.02 0.02 CD cord-254317-n2knqj4z 340 22 diluted dilute VBN cord-254317-n2knqj4z 340 23 in in IN cord-254317-n2knqj4z 340 24 the the DT cord-254317-n2knqj4z 340 25 medium medium NN cord-254317-n2knqj4z 340 26 containing contain VBG cord-254317-n2knqj4z 340 27 10 10 CD cord-254317-n2knqj4z 340 28 μg μg NN cord-254317-n2knqj4z 340 29 / / SYM cord-254317-n2knqj4z 340 30 mL ml NN cord-254317-n2knqj4z 340 31 trypsin trypsin NN cord-254317-n2knqj4z 340 32 . . . cord-254317-n2knqj4z 341 1 After after IN cord-254317-n2knqj4z 341 2 incubation incubation NN cord-254317-n2knqj4z 341 3 at at IN cord-254317-n2knqj4z 341 4 37 37 CD cord-254317-n2knqj4z 341 5 ℃ ℃ NNS cord-254317-n2knqj4z 341 6 for for IN cord-254317-n2knqj4z 341 7 2 2 CD cord-254317-n2knqj4z 341 8 h h NN cord-254317-n2knqj4z 341 9 , , , cord-254317-n2knqj4z 341 10 the the DT cord-254317-n2knqj4z 341 11 inoculum inoculum NN cord-254317-n2knqj4z 341 12 was be VBD cord-254317-n2knqj4z 341 13 removed remove VBN cord-254317-n2knqj4z 341 14 followed follow VBN cord-254317-n2knqj4z 341 15 by by IN cord-254317-n2knqj4z 341 16 three three CD cord-254317-n2knqj4z 341 17 washings washing NNS cord-254317-n2knqj4z 341 18 . . . cord-254317-n2knqj4z 342 1 DMEM DMEM NNP cord-254317-n2knqj4z 342 2 / / SYM cord-254317-n2knqj4z 342 3 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 342 4 containing contain VBG cord-254317-n2knqj4z 342 5 50 50 CD cord-254317-n2knqj4z 342 6 μg μg NNS cord-254317-n2knqj4z 342 7 / / SYM cord-254317-n2knqj4z 342 8 mL ml NN cord-254317-n2knqj4z 342 9 soybean soybean NN cord-254317-n2knqj4z 342 10 trypsin trypsin NN cord-254317-n2knqj4z 342 11 inhibitor inhibitor NN cord-254317-n2knqj4z 342 12 ( ( -LRB- cord-254317-n2knqj4z 342 13 SBTI SBTI NNP cord-254317-n2knqj4z 342 14 ) ) -RRB- cord-254317-n2knqj4z 342 15 and and CC cord-254317-n2knqj4z 342 16 swine swine VB cord-254317-n2knqj4z 342 17 PEDV PEDV NNP cord-254317-n2knqj4z 342 18 positive positive JJ cord-254317-n2knqj4z 342 19 serum serum NN cord-254317-n2knqj4z 342 20 ( ( -LRB- cord-254317-n2knqj4z 342 21 virus virus NN cord-254317-n2knqj4z 342 22 neutralization neutralization NN cord-254317-n2knqj4z 342 23 titer titer NN cord-254317-n2knqj4z 342 24 1:1024 1:1024 NNP cord-254317-n2knqj4z 342 25 , , , cord-254317-n2knqj4z 342 26 1:500 1:500 CD cord-254317-n2knqj4z 342 27 dilution dilution NN cord-254317-n2knqj4z 342 28 ) ) -RRB- cord-254317-n2knqj4z 342 29 was be VBD cord-254317-n2knqj4z 342 30 added add VBN cord-254317-n2knqj4z 342 31 . . . cord-254317-n2knqj4z 343 1 At at IN cord-254317-n2knqj4z 343 2 8 8 CD cord-254317-n2knqj4z 343 3 hpi hpi NNP cord-254317-n2knqj4z 343 4 , , , cord-254317-n2knqj4z 343 5 cells cell NNS cord-254317-n2knqj4z 343 6 were be VBD cord-254317-n2knqj4z 343 7 fixed fix VBN cord-254317-n2knqj4z 343 8 with with IN cord-254317-n2knqj4z 343 9 acetone acetone NN cord-254317-n2knqj4z 343 10 - - HYPH cord-254317-n2knqj4z 343 11 methanol methanol NN cord-254317-n2knqj4z 343 12 ( ( -LRB- cord-254317-n2knqj4z 343 13 1:4 1:4 CD cord-254317-n2knqj4z 343 14 ) ) -RRB- cord-254317-n2knqj4z 343 15 and and CC cord-254317-n2knqj4z 343 16 infectivity infectivity NN cord-254317-n2knqj4z 343 17 was be VBD cord-254317-n2knqj4z 343 18 tested test VBN cord-254317-n2knqj4z 343 19 by by IN cord-254317-n2knqj4z 343 20 IF IF NNP cord-254317-n2knqj4z 343 21 assay assay NN cord-254317-n2knqj4z 343 22 . . . cord-254317-n2knqj4z 344 1 Each each DT cord-254317-n2knqj4z 344 2 Experiment experiment NN cord-254317-n2knqj4z 344 3 was be VBD cord-254317-n2knqj4z 344 4 performed perform VBN cord-254317-n2knqj4z 344 5 three three CD cord-254317-n2knqj4z 344 6 times time NNS cord-254317-n2knqj4z 344 7 . . . cord-254317-n2knqj4z 345 1 Data datum NNS cord-254317-n2knqj4z 345 2 are be VBP cord-254317-n2knqj4z 345 3 shown show VBN cord-254317-n2knqj4z 345 4 as as IN cord-254317-n2knqj4z 345 5 the the DT cord-254317-n2knqj4z 345 6 M M NNP cord-254317-n2knqj4z 345 7 ± ± NNP cord-254317-n2knqj4z 345 8 SD SD NNP cord-254317-n2knqj4z 345 9 , , , cord-254317-n2knqj4z 345 10 and and CC cord-254317-n2knqj4z 345 11 number number NN cord-254317-n2knqj4z 345 12 of of IN cord-254317-n2knqj4z 345 13 asterisks asterisk NNS cord-254317-n2knqj4z 345 14 indicate indicate VBP cord-254317-n2knqj4z 345 15 significant significant JJ cord-254317-n2knqj4z 345 16 difference difference NN cord-254317-n2knqj4z 345 17 between between IN cord-254317-n2knqj4z 345 18 groups group NNS cord-254317-n2knqj4z 345 19 ( ( -LRB- cord-254317-n2knqj4z 345 20 * * NFP cord-254317-n2knqj4z 345 21 , , , cord-254317-n2knqj4z 345 22 p p NN cord-254317-n2knqj4z 345 23 < < XX cord-254317-n2knqj4z 345 24 0.05 0.05 CD cord-254317-n2knqj4z 345 25 ; ; : cord-254317-n2knqj4z 346 1 * * NFP cord-254317-n2knqj4z 346 2 * * NFP cord-254317-n2knqj4z 346 3 , , , cord-254317-n2knqj4z 346 4 P p NN cord-254317-n2knqj4z 346 5 < < XX cord-254317-n2knqj4z 346 6 0.01 0.01 CD cord-254317-n2knqj4z 346 7 ; ; : cord-254317-n2knqj4z 347 1 * * NFP cord-254317-n2knqj4z 347 2 * * NFP cord-254317-n2knqj4z 347 3 * * NFP cord-254317-n2knqj4z 347 4 , , , cord-254317-n2knqj4z 347 5 P p NN cord-254317-n2knqj4z 347 6 < < XX cord-254317-n2knqj4z 347 7 0.001 0.001 CD cord-254317-n2knqj4z 347 8 ) ) -RRB- cord-254317-n2knqj4z 347 9 . . . cord-254317-n2knqj4z 348 1 Fig Fig NNP cord-254317-n2knqj4z 348 2 . . . cord-254317-n2knqj4z 349 1 5 5 LS cord-254317-n2knqj4z 349 2 . . . cord-254317-n2knqj4z 350 1 Effect effect NN cord-254317-n2knqj4z 350 2 of of IN cord-254317-n2knqj4z 350 3 bovine bovine JJ cord-254317-n2knqj4z 350 4 mucin mucin NN cord-254317-n2knqj4z 350 5 ( ( -LRB- cord-254317-n2knqj4z 350 6 BM BM NNP cord-254317-n2knqj4z 350 7 ) ) -RRB- cord-254317-n2knqj4z 350 8 and and CC cord-254317-n2knqj4z 350 9 porcine porcine JJ cord-254317-n2knqj4z 350 10 gastric gastric JJ cord-254317-n2knqj4z 350 11 mucin mucin NN cord-254317-n2knqj4z 350 12 ( ( -LRB- cord-254317-n2knqj4z 350 13 PGM PGM NNP cord-254317-n2knqj4z 350 14 ) ) -RRB- cord-254317-n2knqj4z 350 15 on on IN cord-254317-n2knqj4z 350 16 the the DT cord-254317-n2knqj4z 350 17 infection infection NN cord-254317-n2knqj4z 350 18 of of IN cord-254317-n2knqj4z 350 19 PEDV PEDV NNP cord-254317-n2knqj4z 350 20 icPC22A icPC22A NNP cord-254317-n2knqj4z 350 21 and and CC cord-254317-n2knqj4z 350 22 icPC22A icPC22A NNP cord-254317-n2knqj4z 350 23 - - HYPH cord-254317-n2knqj4z 350 24 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 350 25 in in IN cord-254317-n2knqj4z 350 26 Vero Vero NNP cord-254317-n2knqj4z 350 27 ( ( -LRB- cord-254317-n2knqj4z 350 28 A a NN cord-254317-n2knqj4z 350 29 and and CC cord-254317-n2knqj4z 350 30 B b NN cord-254317-n2knqj4z 350 31 ) ) -RRB- cord-254317-n2knqj4z 350 32 and and CC cord-254317-n2knqj4z 350 33 IPEC IPEC NNP cord-254317-n2knqj4z 350 34 - - HYPH cord-254317-n2knqj4z 350 35 DQ dq NN cord-254317-n2knqj4z 350 36 cells cell NNS cord-254317-n2knqj4z 350 37 ( ( -LRB- cord-254317-n2knqj4z 350 38 C c NN cord-254317-n2knqj4z 350 39 and and CC cord-254317-n2knqj4z 350 40 D D NNP cord-254317-n2knqj4z 350 41 ) ) -RRB- cord-254317-n2knqj4z 350 42 . . . cord-254317-n2knqj4z 351 1 Monolayers Monolayers NNP cord-254317-n2knqj4z 351 2 of of IN cord-254317-n2knqj4z 351 3 Vero Vero NNP cord-254317-n2knqj4z 351 4 or or CC cord-254317-n2knqj4z 351 5 IPEC IPEC NNP cord-254317-n2knqj4z 351 6 - - HYPH cord-254317-n2knqj4z 351 7 DQ dq NN cord-254317-n2knqj4z 351 8 cells cell NNS cord-254317-n2knqj4z 351 9 in in IN cord-254317-n2knqj4z 351 10 96-well 96-well CD cord-254317-n2knqj4z 351 11 plates plate NNS cord-254317-n2knqj4z 351 12 were be VBD cord-254317-n2knqj4z 351 13 inoculated inoculate VBN cord-254317-n2knqj4z 351 14 with with IN cord-254317-n2knqj4z 351 15 a a DT cord-254317-n2knqj4z 351 16 MOI MOI NNP cord-254317-n2knqj4z 351 17 of of IN cord-254317-n2knqj4z 351 18 0.02 0.02 CD cord-254317-n2knqj4z 351 19 icPC22A icPC22A NNP cord-254317-n2knqj4z 351 20 or or CC cord-254317-n2knqj4z 351 21 icPC22A icPC22A NNP cord-254317-n2knqj4z 351 22 - - HYPH cord-254317-n2knqj4z 351 23 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 351 24 in in IN cord-254317-n2knqj4z 351 25 medium medium NN cord-254317-n2knqj4z 351 26 containing contain VBG cord-254317-n2knqj4z 351 27 10 10 CD cord-254317-n2knqj4z 352 1 μg μg NNP cord-254317-n2knqj4z 352 2 / / SYM cord-254317-n2knqj4z 352 3 mL ml NN cord-254317-n2knqj4z 352 4 trypsin trypsin NN cord-254317-n2knqj4z 352 5 and and CC cord-254317-n2knqj4z 352 6 different different JJ cord-254317-n2knqj4z 352 7 concentrations concentration NNS cord-254317-n2knqj4z 352 8 of of IN cord-254317-n2knqj4z 352 9 BM BM NNP cord-254317-n2knqj4z 352 10 or or CC cord-254317-n2knqj4z 352 11 PGM PGM NNP cord-254317-n2knqj4z 352 12 . . . cord-254317-n2knqj4z 353 1 After after IN cord-254317-n2knqj4z 353 2 incubation incubation NN cord-254317-n2knqj4z 353 3 at at IN cord-254317-n2knqj4z 353 4 37 37 CD cord-254317-n2knqj4z 353 5 ℃ ℃ NNS cord-254317-n2knqj4z 353 6 for for IN cord-254317-n2knqj4z 353 7 2 2 CD cord-254317-n2knqj4z 353 8 h h NN cord-254317-n2knqj4z 353 9 , , , cord-254317-n2knqj4z 353 10 the the DT cord-254317-n2knqj4z 353 11 inoculum inoculum NN cord-254317-n2knqj4z 353 12 was be VBD cord-254317-n2knqj4z 353 13 removed remove VBN cord-254317-n2knqj4z 353 14 followed follow VBN cord-254317-n2knqj4z 353 15 by by IN cord-254317-n2knqj4z 353 16 three three CD cord-254317-n2knqj4z 353 17 washings washing NNS cord-254317-n2knqj4z 353 18 . . . cord-254317-n2knqj4z 354 1 DMEM DMEM NNP cord-254317-n2knqj4z 354 2 / / SYM cord-254317-n2knqj4z 354 3 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 354 4 containing contain VBG cord-254317-n2knqj4z 354 5 50 50 CD cord-254317-n2knqj4z 354 6 μg μg NNS cord-254317-n2knqj4z 354 7 / / SYM cord-254317-n2knqj4z 354 8 mL ml NN cord-254317-n2knqj4z 354 9 soybean soybean NN cord-254317-n2knqj4z 354 10 trypsin trypsin NN cord-254317-n2knqj4z 354 11 inhibitor inhibitor NN cord-254317-n2knqj4z 354 12 ( ( -LRB- cord-254317-n2knqj4z 354 13 SBTI SBTI NNP cord-254317-n2knqj4z 354 14 ) ) -RRB- cord-254317-n2knqj4z 354 15 and and CC cord-254317-n2knqj4z 354 16 swine swine VB cord-254317-n2knqj4z 354 17 PEDV PEDV NNP cord-254317-n2knqj4z 354 18 positive positive JJ cord-254317-n2knqj4z 354 19 serum serum NN cord-254317-n2knqj4z 354 20 ( ( -LRB- cord-254317-n2knqj4z 354 21 virus virus NN cord-254317-n2knqj4z 354 22 neutralization neutralization NN cord-254317-n2knqj4z 354 23 titer titer NN cord-254317-n2knqj4z 354 24 1:1024 1:1024 NNP cord-254317-n2knqj4z 354 25 , , , cord-254317-n2knqj4z 354 26 1:500 1:500 CD cord-254317-n2knqj4z 354 27 dilution dilution NN cord-254317-n2knqj4z 354 28 ) ) -RRB- cord-254317-n2knqj4z 354 29 was be VBD cord-254317-n2knqj4z 354 30 added add VBN cord-254317-n2knqj4z 354 31 . . . cord-254317-n2knqj4z 355 1 At at IN cord-254317-n2knqj4z 355 2 8 8 CD cord-254317-n2knqj4z 355 3 hpi hpi NNP cord-254317-n2knqj4z 355 4 , , , cord-254317-n2knqj4z 355 5 cells cell NNS cord-254317-n2knqj4z 355 6 were be VBD cord-254317-n2knqj4z 355 7 fixed fix VBN cord-254317-n2knqj4z 355 8 with with IN cord-254317-n2knqj4z 355 9 acetone acetone NN cord-254317-n2knqj4z 355 10 - - HYPH cord-254317-n2knqj4z 355 11 methanol methanol NN cord-254317-n2knqj4z 355 12 ( ( -LRB- cord-254317-n2knqj4z 355 13 1:4 1:4 CD cord-254317-n2knqj4z 355 14 ) ) -RRB- cord-254317-n2knqj4z 355 15 and and CC cord-254317-n2knqj4z 355 16 infectivity infectivity NN cord-254317-n2knqj4z 355 17 was be VBD cord-254317-n2knqj4z 355 18 tested test VBN cord-254317-n2knqj4z 355 19 by by IN cord-254317-n2knqj4z 355 20 IF IF NNP cord-254317-n2knqj4z 355 21 assay assay NN cord-254317-n2knqj4z 355 22 . . . cord-254317-n2knqj4z 356 1 Each each DT cord-254317-n2knqj4z 356 2 Experiment experiment NN cord-254317-n2knqj4z 356 3 was be VBD cord-254317-n2knqj4z 356 4 performed perform VBN cord-254317-n2knqj4z 356 5 three three CD cord-254317-n2knqj4z 356 6 times time NNS cord-254317-n2knqj4z 356 7 . . . cord-254317-n2knqj4z 357 1 Data datum NNS cord-254317-n2knqj4z 357 2 are be VBP cord-254317-n2knqj4z 357 3 shown show VBN cord-254317-n2knqj4z 357 4 as as IN cord-254317-n2knqj4z 357 5 M M NNP cord-254317-n2knqj4z 357 6 ± ± NNP cord-254317-n2knqj4z 357 7 SD SD NNP cord-254317-n2knqj4z 357 8 , , , cord-254317-n2knqj4z 357 9 and and CC cord-254317-n2knqj4z 357 10 number number NN cord-254317-n2knqj4z 357 11 of of IN cord-254317-n2knqj4z 357 12 asterisks asterisk NNS cord-254317-n2knqj4z 357 13 indicate indicate VBP cord-254317-n2knqj4z 357 14 significant significant JJ cord-254317-n2knqj4z 357 15 difference difference NN cord-254317-n2knqj4z 357 16 between between IN cord-254317-n2knqj4z 357 17 groups group NNS cord-254317-n2knqj4z 357 18 ( ( -LRB- cord-254317-n2knqj4z 357 19 * * NFP cord-254317-n2knqj4z 357 20 , , , cord-254317-n2knqj4z 357 21 p p NN cord-254317-n2knqj4z 357 22 < < XX cord-254317-n2knqj4z 357 23 0.05 0.05 CD cord-254317-n2knqj4z 357 24 ; ; : cord-254317-n2knqj4z 358 1 * * NFP cord-254317-n2knqj4z 358 2 * * NFP cord-254317-n2knqj4z 358 3 , , , cord-254317-n2knqj4z 358 4 P p NN cord-254317-n2knqj4z 358 5 < < XX cord-254317-n2knqj4z 358 6 0.01 0.01 CD cord-254317-n2knqj4z 358 7 ; ; : cord-254317-n2knqj4z 359 1 * * NFP cord-254317-n2knqj4z 359 2 * * NFP cord-254317-n2knqj4z 359 3 * * NFP cord-254317-n2knqj4z 359 4 , , , cord-254317-n2knqj4z 359 5 P p NN cord-254317-n2knqj4z 359 6 < < XX cord-254317-n2knqj4z 359 7 0.001 0.001 CD cord-254317-n2knqj4z 359 8 ) ) -RRB- cord-254317-n2knqj4z 359 9 . . . cord-254317-n2knqj4z 360 1 del del NNP cord-254317-n2knqj4z 360 2 and and CC cord-254317-n2knqj4z 360 3 S S NNP cord-254317-n2knqj4z 360 4 - - HYPH cord-254317-n2knqj4z 360 5 intact intact JJ cord-254317-n2knqj4z 360 6 PEDVs pedv NNS cord-254317-n2knqj4z 360 7 during during IN cord-254317-n2knqj4z 360 8 coinfection coinfection NN cord-254317-n2knqj4z 360 9 in in IN cord-254317-n2knqj4z 360 10 pigs pig NNS cord-254317-n2knqj4z 360 11 . . . cord-254317-n2knqj4z 361 1 We -PRON- PRP cord-254317-n2knqj4z 361 2 developed develop VBD cord-254317-n2knqj4z 361 3 a a DT cord-254317-n2knqj4z 361 4 duplex duplex JJ cord-254317-n2knqj4z 361 5 RT rt NN cord-254317-n2knqj4z 361 6 - - HYPH cord-254317-n2knqj4z 361 7 qPCR qPCR NNP cord-254317-n2knqj4z 361 8 targeting target VBG cord-254317-n2knqj4z 361 9 the the DT cord-254317-n2knqj4z 361 10 S S NNP cord-254317-n2knqj4z 361 11 gene gene NN cord-254317-n2knqj4z 361 12 of of IN cord-254317-n2knqj4z 361 13 PEDV PEDV NNP cord-254317-n2knqj4z 361 14 to to TO cord-254317-n2knqj4z 361 15 differentiate differentiate VB cord-254317-n2knqj4z 361 16 the the DT cord-254317-n2knqj4z 361 17 two two CD cord-254317-n2knqj4z 361 18 viruses virus NNS cord-254317-n2knqj4z 361 19 . . . cord-254317-n2knqj4z 362 1 We -PRON- PRP cord-254317-n2knqj4z 362 2 found find VBD cord-254317-n2knqj4z 362 3 that that IN cord-254317-n2knqj4z 362 4 the the DT cord-254317-n2knqj4z 362 5 duplex duplex JJ cord-254317-n2knqj4z 362 6 RT rt NN cord-254317-n2knqj4z 362 7 - - HYPH cord-254317-n2knqj4z 362 8 qPCR qpcr NN cord-254317-n2knqj4z 362 9 assay assay NN cord-254317-n2knqj4z 362 10 had have VBD cord-254317-n2knqj4z 362 11 different different JJ cord-254317-n2knqj4z 362 12 sensitivities sensitivity NNS cord-254317-n2knqj4z 362 13 for for IN cord-254317-n2knqj4z 362 14 the the DT cord-254317-n2knqj4z 362 15 detection detection NN cord-254317-n2knqj4z 362 16 of of IN cord-254317-n2knqj4z 362 17 infectious infectious JJ cord-254317-n2knqj4z 362 18 icPC22 icpc22 NN cord-254317-n2knqj4z 362 19 A a NN cord-254317-n2knqj4z 362 20 and and CC cord-254317-n2knqj4z 362 21 icPC22 icpc22 NN cord-254317-n2knqj4z 363 1 A a LS cord-254317-n2knqj4z 363 2 - - HYPH cord-254317-n2knqj4z 363 3 S1Δ197 s1δ197 JJ cord-254317-n2knqj4z 363 4 ( ( -LRB- cord-254317-n2knqj4z 363 5 Table Table NNP cord-254317-n2knqj4z 363 6 S1 S1 NNP cord-254317-n2knqj4z 363 7 ) ) -RRB- cord-254317-n2knqj4z 363 8 although although IN cord-254317-n2knqj4z 363 9 it -PRON- PRP cord-254317-n2knqj4z 363 10 had have VBD cord-254317-n2knqj4z 363 11 a a DT cord-254317-n2knqj4z 363 12 similar similar JJ cord-254317-n2knqj4z 363 13 detection detection NN cord-254317-n2knqj4z 363 14 limit limit NN cord-254317-n2knqj4z 363 15 ( ( -LRB- cord-254317-n2knqj4z 363 16 5 5 CD cord-254317-n2knqj4z 363 17 log log NN cord-254317-n2knqj4z 363 18 10 10 CD cord-254317-n2knqj4z 363 19 copies copy NNS cord-254317-n2knqj4z 363 20 / / SYM cord-254317-n2knqj4z 363 21 mL ml NN cord-254317-n2knqj4z 363 22 ) ) -RRB- cord-254317-n2knqj4z 363 23 for for IN cord-254317-n2knqj4z 363 24 both both DT cord-254317-n2knqj4z 363 25 viruses virus NNS cord-254317-n2knqj4z 363 26 . . . cord-254317-n2knqj4z 364 1 For for IN cord-254317-n2knqj4z 364 2 example example NN cord-254317-n2knqj4z 364 3 , , , cord-254317-n2knqj4z 364 4 9 9 CD cord-254317-n2knqj4z 364 5 log log NN cord-254317-n2knqj4z 365 1 10 10 CD cord-254317-n2knqj4z 365 2 S s NN cord-254317-n2knqj4z 365 3 gene gene NN cord-254317-n2knqj4z 365 4 copies/ copies/ CD cord-254317-n2knqj4z 365 5 mL ml NN cord-254317-n2knqj4z 365 6 corresponded correspond VBD cord-254317-n2knqj4z 365 7 to to IN cord-254317-n2knqj4z 365 8 6.2 6.2 CD cord-254317-n2knqj4z 365 9 and and CC cord-254317-n2knqj4z 365 10 4.2 4.2 CD cord-254317-n2knqj4z 365 11 log log VB cord-254317-n2knqj4z 365 12 10 10 CD cord-254317-n2knqj4z 365 13 FFU FFU NNP cord-254317-n2knqj4z 365 14 / / SYM cord-254317-n2knqj4z 365 15 mL ml NN cord-254317-n2knqj4z 365 16 for for IN cord-254317-n2knqj4z 365 17 icPC22A icPC22A NNP cord-254317-n2knqj4z 365 18 and and CC cord-254317-n2knqj4z 365 19 icPC22A icPC22A NNP cord-254317-n2knqj4z 365 20 - - HYPH cord-254317-n2knqj4z 365 21 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 365 22 , , , cord-254317-n2knqj4z 365 23 respectively respectively RB cord-254317-n2knqj4z 365 24 . . . cord-254317-n2knqj4z 366 1 It -PRON- PRP cord-254317-n2knqj4z 366 2 may may MD cord-254317-n2knqj4z 366 3 reflect reflect VB cord-254317-n2knqj4z 366 4 the the DT cord-254317-n2knqj4z 366 5 fact fact NN cord-254317-n2knqj4z 366 6 that that IN cord-254317-n2knqj4z 366 7 icPC22A icPC22A NNP cord-254317-n2knqj4z 366 8 - - HYPH cord-254317-n2knqj4z 366 9 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 366 10 replicates replicate NNS cord-254317-n2knqj4z 366 11 to to TO cord-254317-n2knqj4z 366 12 lower lower VB cord-254317-n2knqj4z 366 13 peak peak NN cord-254317-n2knqj4z 366 14 infectious infectious JJ cord-254317-n2knqj4z 366 15 titers titer NNS cord-254317-n2knqj4z 367 1 ( ( -LRB- cord-254317-n2knqj4z 367 2 ∼5.0 ∼5.0 NNP cord-254317-n2knqj4z 367 3 log log VB cord-254317-n2knqj4z 367 4 10 10 CD cord-254317-n2knqj4z 367 5 FFU FFU NNP cord-254317-n2knqj4z 367 6 / / SYM cord-254317-n2knqj4z 367 7 mL ml NN cord-254317-n2knqj4z 367 8 ) ) -RRB- cord-254317-n2knqj4z 367 9 than than IN cord-254317-n2knqj4z 367 10 that that DT cord-254317-n2knqj4z 368 1 ( ( -LRB- cord-254317-n2knqj4z 368 2 ∼7.0 ∼7.0 UH cord-254317-n2knqj4z 368 3 log log VB cord-254317-n2knqj4z 368 4 10 10 CD cord-254317-n2knqj4z 368 5 FFU FFU NNP cord-254317-n2knqj4z 368 6 / / SYM cord-254317-n2knqj4z 368 7 mL ml NN cord-254317-n2knqj4z 368 8 ) ) -RRB- cord-254317-n2knqj4z 368 9 of of IN cord-254317-n2knqj4z 368 10 icPC22A icPC22A NNP cord-254317-n2knqj4z 368 11 in in IN cord-254317-n2knqj4z 368 12 Vero Vero NNP cord-254317-n2knqj4z 368 13 cells cell NNS cord-254317-n2knqj4z 368 14 although although IN cord-254317-n2knqj4z 368 15 both both DT cord-254317-n2knqj4z 368 16 viruses virus NNS cord-254317-n2knqj4z 368 17 replicated replicate VBN cord-254317-n2knqj4z 368 18 to to IN cord-254317-n2knqj4z 368 19 similar similar JJ cord-254317-n2knqj4z 368 20 peak peak NN cord-254317-n2knqj4z 368 21 titers titer NNS cord-254317-n2knqj4z 368 22 based base VBN cord-254317-n2knqj4z 368 23 on on IN cord-254317-n2knqj4z 368 24 the the DT cord-254317-n2knqj4z 368 25 S S NNP cord-254317-n2knqj4z 368 26 gene gene NN cord-254317-n2knqj4z 368 27 ( ( -LRB- cord-254317-n2knqj4z 368 28 ∼10.0 ∼10.0 NNP cord-254317-n2knqj4z 368 29 log log VB cord-254317-n2knqj4z 368 30 10 10 CD cord-254317-n2knqj4z 368 31 copies copy NNS cord-254317-n2knqj4z 368 32 / / SYM cord-254317-n2knqj4z 368 33 mL ml NN cord-254317-n2knqj4z 368 34 ) ) -RRB- cord-254317-n2knqj4z 368 35 ( ( -LRB- cord-254317-n2knqj4z 368 36 Fig Fig NNP cord-254317-n2knqj4z 368 37 . . . cord-254317-n2knqj4z 368 38 3A 3A NNP cord-254317-n2knqj4z 368 39 ) ) -RRB- cord-254317-n2knqj4z 368 40 . . . cord-254317-n2knqj4z 369 1 In in IN cord-254317-n2knqj4z 369 2 the the DT cord-254317-n2knqj4z 369 3 mixture mixture NN cord-254317-n2knqj4z 369 4 of of IN cord-254317-n2knqj4z 369 5 two two CD cord-254317-n2knqj4z 369 6 viruses virus NNS cord-254317-n2knqj4z 369 7 , , , cord-254317-n2knqj4z 369 8 the the DT cord-254317-n2knqj4z 369 9 detection detection NN cord-254317-n2knqj4z 369 10 Fig Fig NNP cord-254317-n2knqj4z 369 11 . . . cord-254317-n2knqj4z 369 12 6 6 CD cord-254317-n2knqj4z 369 13 . . . cord-254317-n2knqj4z 370 1 Effect effect NN cord-254317-n2knqj4z 370 2 of of IN cord-254317-n2knqj4z 370 3 bile bile NN cord-254317-n2knqj4z 370 4 and and CC cord-254317-n2knqj4z 370 5 bile bile NN cord-254317-n2knqj4z 370 6 acids acid NNS cord-254317-n2knqj4z 370 7 on on IN cord-254317-n2knqj4z 370 8 the the DT cord-254317-n2knqj4z 370 9 infection infection NN cord-254317-n2knqj4z 370 10 of of IN cord-254317-n2knqj4z 370 11 PEDV PEDV NNP cord-254317-n2knqj4z 370 12 icPC22A icPC22A NNP cord-254317-n2knqj4z 370 13 and and CC cord-254317-n2knqj4z 370 14 icPC22A icPC22A NNP cord-254317-n2knqj4z 370 15 - - HYPH cord-254317-n2knqj4z 370 16 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 370 17 in in IN cord-254317-n2knqj4z 370 18 Vero Vero NNP cord-254317-n2knqj4z 370 19 ( ( -LRB- cord-254317-n2knqj4z 370 20 A A NNP cord-254317-n2knqj4z 370 21 - - HYPH cord-254317-n2knqj4z 370 22 E e NN cord-254317-n2knqj4z 370 23 ) ) -RRB- cord-254317-n2knqj4z 370 24 and and CC cord-254317-n2knqj4z 370 25 IPEC IPEC NNP cord-254317-n2knqj4z 370 26 - - HYPH cord-254317-n2knqj4z 370 27 DQ dq NN cord-254317-n2knqj4z 370 28 cells cell NNS cord-254317-n2knqj4z 370 29 ( ( -LRB- cord-254317-n2knqj4z 370 30 F F NNP cord-254317-n2knqj4z 370 31 - - HYPH cord-254317-n2knqj4z 370 32 J J NNP cord-254317-n2knqj4z 370 33 ) ) -RRB- cord-254317-n2knqj4z 370 34 . . . cord-254317-n2knqj4z 371 1 Monolayers Monolayers NNP cord-254317-n2knqj4z 371 2 of of IN cord-254317-n2knqj4z 371 3 Vero Vero NNP cord-254317-n2knqj4z 371 4 or or CC cord-254317-n2knqj4z 371 5 IPEC IPEC NNP cord-254317-n2knqj4z 371 6 - - HYPH cord-254317-n2knqj4z 371 7 DQ dq NN cord-254317-n2knqj4z 371 8 cells cell NNS cord-254317-n2knqj4z 371 9 in in IN cord-254317-n2knqj4z 371 10 96-well 96-well CD cord-254317-n2knqj4z 371 11 plates plate NNS cord-254317-n2knqj4z 371 12 were be VBD cord-254317-n2knqj4z 371 13 inoculated inoculate VBN cord-254317-n2knqj4z 371 14 with with IN cord-254317-n2knqj4z 371 15 a a DT cord-254317-n2knqj4z 371 16 MOI MOI NNP cord-254317-n2knqj4z 371 17 of of IN cord-254317-n2knqj4z 371 18 0.02 0.02 CD cord-254317-n2knqj4z 371 19 icPC22 icpc22 NN cord-254317-n2knqj4z 372 1 A a NN cord-254317-n2knqj4z 372 2 or or CC cord-254317-n2knqj4z 372 3 icPC22 icpc22 NN cord-254317-n2knqj4z 373 1 A a LS cord-254317-n2knqj4z 373 2 - - HYPH cord-254317-n2knqj4z 373 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 373 4 in in IN cord-254317-n2knqj4z 373 5 medium medium NN cord-254317-n2knqj4z 373 6 containing contain VBG cord-254317-n2knqj4z 373 7 10 10 CD cord-254317-n2knqj4z 374 1 μg μg NNP cord-254317-n2knqj4z 374 2 / / SYM cord-254317-n2knqj4z 374 3 mL ml NN cord-254317-n2knqj4z 374 4 trypsin trypsin NN cord-254317-n2knqj4z 374 5 and and CC cord-254317-n2knqj4z 374 6 different different JJ cord-254317-n2knqj4z 374 7 concentrations concentration NNS cord-254317-n2knqj4z 374 8 of of IN cord-254317-n2knqj4z 374 9 bile bile NN cord-254317-n2knqj4z 374 10 or or CC cord-254317-n2knqj4z 374 11 bile bile NN cord-254317-n2knqj4z 374 12 acids acid NNS cord-254317-n2knqj4z 374 13 . . . cord-254317-n2knqj4z 375 1 After after IN cord-254317-n2knqj4z 375 2 incubation incubation NN cord-254317-n2knqj4z 375 3 at at IN cord-254317-n2knqj4z 375 4 37 37 CD cord-254317-n2knqj4z 375 5 ℃ ℃ NNS cord-254317-n2knqj4z 375 6 for for IN cord-254317-n2knqj4z 375 7 2 2 CD cord-254317-n2knqj4z 375 8 h h NN cord-254317-n2knqj4z 375 9 , , , cord-254317-n2knqj4z 375 10 the the DT cord-254317-n2knqj4z 375 11 inoculum inoculum NN cord-254317-n2knqj4z 375 12 was be VBD cord-254317-n2knqj4z 375 13 removed remove VBN cord-254317-n2knqj4z 375 14 followed follow VBN cord-254317-n2knqj4z 375 15 by by IN cord-254317-n2knqj4z 375 16 three three CD cord-254317-n2knqj4z 375 17 washings washing NNS cord-254317-n2knqj4z 375 18 . . . cord-254317-n2knqj4z 376 1 DMEM DMEM NNP cord-254317-n2knqj4z 376 2 / / SYM cord-254317-n2knqj4z 376 3 RPMI-1640 RPMI-1640 NNP cord-254317-n2knqj4z 376 4 containing contain VBG cord-254317-n2knqj4z 376 5 50 50 CD cord-254317-n2knqj4z 376 6 μg μg NNS cord-254317-n2knqj4z 376 7 / / SYM cord-254317-n2knqj4z 376 8 mL mL NNP cord-254317-n2knqj4z 376 9 SBTI SBTI NNP cord-254317-n2knqj4z 376 10 and and CC cord-254317-n2knqj4z 376 11 swine swine NN cord-254317-n2knqj4z 376 12 PEDV PEDV NNP cord-254317-n2knqj4z 376 13 positive positive JJ cord-254317-n2knqj4z 376 14 serum serum NN cord-254317-n2knqj4z 377 1 ( ( -LRB- cord-254317-n2knqj4z 377 2 virus virus NN cord-254317-n2knqj4z 377 3 neutralization neutralization NN cord-254317-n2knqj4z 377 4 titer titer NN cord-254317-n2knqj4z 377 5 1:1024 1:1024 NNP cord-254317-n2knqj4z 377 6 , , , cord-254317-n2knqj4z 377 7 1:500 1:500 CD cord-254317-n2knqj4z 377 8 dilution dilution NN cord-254317-n2knqj4z 377 9 ) ) -RRB- cord-254317-n2knqj4z 377 10 was be VBD cord-254317-n2knqj4z 377 11 added add VBN cord-254317-n2knqj4z 377 12 . . . cord-254317-n2knqj4z 378 1 At at IN cord-254317-n2knqj4z 378 2 8 8 CD cord-254317-n2knqj4z 378 3 hpi hpi NNP cord-254317-n2knqj4z 378 4 , , , cord-254317-n2knqj4z 378 5 cells cell NNS cord-254317-n2knqj4z 378 6 were be VBD cord-254317-n2knqj4z 378 7 fixed fix VBN cord-254317-n2knqj4z 378 8 with with IN cord-254317-n2knqj4z 378 9 acetone acetone NN cord-254317-n2knqj4z 378 10 - - HYPH cord-254317-n2knqj4z 378 11 methanol methanol NN cord-254317-n2knqj4z 378 12 ( ( -LRB- cord-254317-n2knqj4z 378 13 1:4 1:4 CD cord-254317-n2knqj4z 378 14 ) ) -RRB- cord-254317-n2knqj4z 378 15 and and CC cord-254317-n2knqj4z 378 16 infectivity infectivity NN cord-254317-n2knqj4z 378 17 was be VBD cord-254317-n2knqj4z 378 18 tested test VBN cord-254317-n2knqj4z 378 19 by by IN cord-254317-n2knqj4z 378 20 IF IF NNP cord-254317-n2knqj4z 378 21 assay assay NN cord-254317-n2knqj4z 378 22 . . . cord-254317-n2knqj4z 379 1 Each each DT cord-254317-n2knqj4z 379 2 Experiment experiment NN cord-254317-n2knqj4z 379 3 was be VBD cord-254317-n2knqj4z 379 4 performed perform VBN cord-254317-n2knqj4z 379 5 three three CD cord-254317-n2knqj4z 379 6 times time NNS cord-254317-n2knqj4z 379 7 . . . cord-254317-n2knqj4z 380 1 Data datum NNS cord-254317-n2knqj4z 380 2 are be VBP cord-254317-n2knqj4z 380 3 shown show VBN cord-254317-n2knqj4z 380 4 as as IN cord-254317-n2knqj4z 380 5 M M NNP cord-254317-n2knqj4z 380 6 ± ± NNP cord-254317-n2knqj4z 380 7 SD SD NNP cord-254317-n2knqj4z 380 8 , , , cord-254317-n2knqj4z 380 9 and and CC cord-254317-n2knqj4z 380 10 number number NN cord-254317-n2knqj4z 380 11 of of IN cord-254317-n2knqj4z 380 12 asterisks asterisk NNS cord-254317-n2knqj4z 380 13 indicate indicate VBP cord-254317-n2knqj4z 380 14 significant significant JJ cord-254317-n2knqj4z 380 15 difference difference NN cord-254317-n2knqj4z 380 16 between between IN cord-254317-n2knqj4z 380 17 groups group NNS cord-254317-n2knqj4z 380 18 ( ( -LRB- cord-254317-n2knqj4z 380 19 * * NFP cord-254317-n2knqj4z 380 20 , , , cord-254317-n2knqj4z 380 21 p p NN cord-254317-n2knqj4z 380 22 < < XX cord-254317-n2knqj4z 380 23 0.05 0.05 CD cord-254317-n2knqj4z 380 24 ; ; : cord-254317-n2knqj4z 381 1 * * NFP cord-254317-n2knqj4z 381 2 * * NFP cord-254317-n2knqj4z 381 3 , , , cord-254317-n2knqj4z 381 4 P p NN cord-254317-n2knqj4z 381 5 < < XX cord-254317-n2knqj4z 381 6 0.01 0.01 CD cord-254317-n2knqj4z 381 7 ; ; : cord-254317-n2knqj4z 382 1 * * NFP cord-254317-n2knqj4z 382 2 * * NFP cord-254317-n2knqj4z 382 3 * * NFP cord-254317-n2knqj4z 382 4 , , , cord-254317-n2knqj4z 382 5 P p NN cord-254317-n2knqj4z 382 6 < < XX cord-254317-n2knqj4z 382 7 0.001 0.001 CD cord-254317-n2knqj4z 382 8 ) ) -RRB- cord-254317-n2knqj4z 382 9 . . . cord-254317-n2knqj4z 383 1 sensitivity sensitivity NN cord-254317-n2knqj4z 383 2 of of IN cord-254317-n2knqj4z 383 3 each each DT cord-254317-n2knqj4z 383 4 virus virus NN cord-254317-n2knqj4z 383 5 differed differ VBD cord-254317-n2knqj4z 383 6 significantly significantly RB cord-254317-n2knqj4z 383 7 ( ( -LRB- cord-254317-n2knqj4z 383 8 Tables Tables NNP cord-254317-n2knqj4z 383 9 S2 S2 NNP cord-254317-n2knqj4z 383 10 ) ) -RRB- cord-254317-n2knqj4z 383 11 . . . cord-254317-n2knqj4z 384 1 For for IN cord-254317-n2knqj4z 384 2 the the DT cord-254317-n2knqj4z 384 3 detection detection NN cord-254317-n2knqj4z 384 4 of of IN cord-254317-n2knqj4z 384 5 icPC22 icpc22 NN cord-254317-n2knqj4z 385 1 A a DT cord-254317-n2knqj4z 385 2 at at IN cord-254317-n2knqj4z 385 3 high high JJ cord-254317-n2knqj4z 385 4 titers titer NNS cord-254317-n2knqj4z 385 5 ( ( -LRB- cord-254317-n2knqj4z 385 6 6.2 6.2 CD cord-254317-n2knqj4z 385 7 log log NN cord-254317-n2knqj4z 385 8 10 10 CD cord-254317-n2knqj4z 385 9 FFU FFU NNP cord-254317-n2knqj4z 385 10 / / SYM cord-254317-n2knqj4z 385 11 mL ml NN cord-254317-n2knqj4z 385 12 ) ) -RRB- cord-254317-n2knqj4z 385 13 and and CC cord-254317-n2knqj4z 385 14 as as IN cord-254317-n2knqj4z 385 15 the the DT cord-254317-n2knqj4z 385 16 predominant predominant JJ cord-254317-n2knqj4z 385 17 virus virus NN cord-254317-n2knqj4z 385 18 in in IN cord-254317-n2knqj4z 385 19 the the DT cord-254317-n2knqj4z 385 20 mixture mixture NN cord-254317-n2knqj4z 385 21 of of IN cord-254317-n2knqj4z 385 22 two two CD cord-254317-n2knqj4z 385 23 viruses virus NNS cord-254317-n2knqj4z 385 24 ( ( -LRB- cord-254317-n2knqj4z 385 25 icPC22A icpc22a CD cord-254317-n2knqj4z 385 26 : : : cord-254317-n2knqj4z 385 27 icPC22 icPC22 . cord-254317-n2knqj4z 386 1 A a LS cord-254317-n2knqj4z 386 2 - - HYPH cord-254317-n2knqj4z 386 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 386 4 = = SYM cord-254317-n2knqj4z 386 5 10 10 CD cord-254317-n2knqj4z 386 6 2 2 CD cord-254317-n2knqj4z 386 7 -10 -10 SYM cord-254317-n2knqj4z 386 8 5 5 CD cord-254317-n2knqj4z 386 9 : : SYM cord-254317-n2knqj4z 386 10 1 1 CD cord-254317-n2knqj4z 386 11 ) ) -RRB- cord-254317-n2knqj4z 386 12 , , , cord-254317-n2knqj4z 386 13 the the DT cord-254317-n2knqj4z 386 14 S S NNP cord-254317-n2knqj4z 386 15 gene gene NN cord-254317-n2knqj4z 386 16 titers titer NNS cord-254317-n2knqj4z 386 17 ( ( -LRB- cord-254317-n2knqj4z 386 18 ∼8.8 ∼8.8 NNP cord-254317-n2knqj4z 386 19 - - HYPH cord-254317-n2knqj4z 386 20 9.1 9.1 CD cord-254317-n2knqj4z 386 21 log log NN cord-254317-n2knqj4z 386 22 10 10 CD cord-254317-n2knqj4z 386 23 S s NN cord-254317-n2knqj4z 386 24 gene gene NN cord-254317-n2knqj4z 386 25 copies/ copies/ CD cord-254317-n2knqj4z 386 26 mL ml NN cord-254317-n2knqj4z 386 27 ) ) -RRB- cord-254317-n2knqj4z 386 28 ( ( -LRB- cord-254317-n2knqj4z 386 29 Table Table NNP cord-254317-n2knqj4z 386 30 S2 s2 NN cord-254317-n2knqj4z 386 31 ) ) -RRB- cord-254317-n2knqj4z 386 32 were be VBD cord-254317-n2knqj4z 386 33 similar similar JJ cord-254317-n2knqj4z 386 34 to to IN cord-254317-n2knqj4z 386 35 that that DT cord-254317-n2knqj4z 386 36 ( ( -LRB- cord-254317-n2knqj4z 386 37 ∼9.0 ∼9.0 TO cord-254317-n2knqj4z 386 38 log log VB cord-254317-n2knqj4z 386 39 10 10 CD cord-254317-n2knqj4z 386 40 S s NN cord-254317-n2knqj4z 386 41 gene gene NN cord-254317-n2knqj4z 386 42 copies copy NNS cord-254317-n2knqj4z 386 43 / / SYM cord-254317-n2knqj4z 386 44 mL mL NNP cord-254317-n2knqj4z 386 45 ) ) -RRB- cord-254317-n2knqj4z 386 46 in in IN cord-254317-n2knqj4z 386 47 the the DT cord-254317-n2knqj4z 386 48 single single JJ cord-254317-n2knqj4z 386 49 virus virus NN cord-254317-n2knqj4z 386 50 alone alone JJ cord-254317-n2knqj4z 386 51 ( ( -LRB- cord-254317-n2knqj4z 386 52 Table Table NNP cord-254317-n2knqj4z 386 53 S1 S1 NNP cord-254317-n2knqj4z 386 54 ) ) -RRB- cord-254317-n2knqj4z 386 55 . . . cord-254317-n2knqj4z 387 1 Because because IN cord-254317-n2knqj4z 387 2 icPC22 icpc22 NN cord-254317-n2knqj4z 388 1 A a DT cord-254317-n2knqj4z 388 2 replicated replicate VBN cord-254317-n2knqj4z 388 3 to to IN cord-254317-n2knqj4z 388 4 high high JJ cord-254317-n2knqj4z 388 5 titers titer NNS cord-254317-n2knqj4z 388 6 and and CC cord-254317-n2knqj4z 388 7 was be VBD cord-254317-n2knqj4z 388 8 the the DT cord-254317-n2knqj4z 388 9 predominant predominant JJ cord-254317-n2knqj4z 388 10 virus virus NN cord-254317-n2knqj4z 388 11 during during IN cord-254317-n2knqj4z 388 12 the the DT cord-254317-n2knqj4z 388 13 coinfection coinfection NN cord-254317-n2knqj4z 388 14 in in IN cord-254317-n2knqj4z 388 15 pigs pig NNS cord-254317-n2knqj4z 388 16 , , , cord-254317-n2knqj4z 388 17 we -PRON- PRP cord-254317-n2knqj4z 388 18 can can MD cord-254317-n2knqj4z 388 19 predict predict VB cord-254317-n2knqj4z 388 20 that that IN cord-254317-n2knqj4z 388 21 the the DT cord-254317-n2knqj4z 388 22 peak peak NN cord-254317-n2knqj4z 388 23 infectious infectious JJ cord-254317-n2knqj4z 388 24 titer titer NN cord-254317-n2knqj4z 388 25 of of IN cord-254317-n2knqj4z 388 26 icPC22A icPC22A NNP cord-254317-n2knqj4z 388 27 in in IN cord-254317-n2knqj4z 388 28 coinfection coinfection NN cord-254317-n2knqj4z 388 29 was be VBD cord-254317-n2knqj4z 388 30 ∼1.0 ∼1.0 TO cord-254317-n2knqj4z 388 31 log log VB cord-254317-n2knqj4z 388 32 10 10 CD cord-254317-n2knqj4z 388 33 -higher -higher NN cord-254317-n2knqj4z 388 34 than than IN cord-254317-n2knqj4z 388 35 that that DT cord-254317-n2knqj4z 388 36 in in IN cord-254317-n2knqj4z 388 37 its -PRON- PRP$ cord-254317-n2knqj4z 388 38 single single JJ cord-254317-n2knqj4z 388 39 infection infection NN cord-254317-n2knqj4z 388 40 based base VBN cord-254317-n2knqj4z 388 41 on on IN cord-254317-n2knqj4z 388 42 the the DT cord-254317-n2knqj4z 388 43 duplex duplex JJ cord-254317-n2knqj4z 388 44 RT rt NN cord-254317-n2knqj4z 388 45 - - HYPH cord-254317-n2knqj4z 388 46 qPCR qpcr NN cord-254317-n2knqj4z 388 47 results result NNS cord-254317-n2knqj4z 388 48 ( ( -LRB- cord-254317-n2knqj4z 388 49 ∼11.4 ∼11.4 NNP cord-254317-n2knqj4z 388 50 vs vs IN cord-254317-n2knqj4z 388 51 ∼10.5 ∼10.5 NNP cord-254317-n2knqj4z 388 52 log log VBP cord-254317-n2knqj4z 388 53 10 10 CD cord-254317-n2knqj4z 388 54 S s NN cord-254317-n2knqj4z 388 55 gene gene NN cord-254317-n2knqj4z 388 56 copies copy NNS cord-254317-n2knqj4z 388 57 / / SYM cord-254317-n2knqj4z 388 58 mL ml NN cord-254317-n2knqj4z 388 59 ) ) -RRB- cord-254317-n2knqj4z 388 60 ( ( -LRB- cord-254317-n2knqj4z 388 61 Table table NN cord-254317-n2knqj4z 388 62 2 2 CD cord-254317-n2knqj4z 388 63 ) ) -RRB- cord-254317-n2knqj4z 388 64 . . . cord-254317-n2knqj4z 389 1 So so RB cord-254317-n2knqj4z 389 2 , , , cord-254317-n2knqj4z 389 3 we -PRON- PRP cord-254317-n2knqj4z 389 4 conclude conclude VBP cord-254317-n2knqj4z 389 5 that that IN cord-254317-n2knqj4z 389 6 the the DT cord-254317-n2knqj4z 389 7 replication replication NN cord-254317-n2knqj4z 389 8 of of IN cord-254317-n2knqj4z 389 9 icPC22A icPC22A NNP cord-254317-n2knqj4z 389 10 was be VBD cord-254317-n2knqj4z 389 11 interfered interfere VBN cord-254317-n2knqj4z 389 12 at at IN cord-254317-n2knqj4z 389 13 the the DT cord-254317-n2knqj4z 389 14 beginning beginning NN cord-254317-n2knqj4z 389 15 based base VBN cord-254317-n2knqj4z 389 16 on on IN cord-254317-n2knqj4z 389 17 delayed delayed JJ cord-254317-n2knqj4z 389 18 timing timing NN cord-254317-n2knqj4z 389 19 ( ( -LRB- cord-254317-n2knqj4z 389 20 1.5 1.5 CD cord-254317-n2knqj4z 389 21 vs vs IN cord-254317-n2knqj4z 389 22 1.0 1.0 CD cord-254317-n2knqj4z 389 23 dpi dpi NN cord-254317-n2knqj4z 389 24 ) ) -RRB- cord-254317-n2knqj4z 389 25 to to TO cord-254317-n2knqj4z 389 26 reach reach VB cord-254317-n2knqj4z 389 27 peak peak NN cord-254317-n2knqj4z 389 28 titers titer NNS cord-254317-n2knqj4z 389 29 but but CC cord-254317-n2knqj4z 389 30 enhanced enhance VBN cord-254317-n2knqj4z 389 31 eventually eventually RB cord-254317-n2knqj4z 389 32 in in IN cord-254317-n2knqj4z 389 33 coinfection coinfection NN cord-254317-n2knqj4z 389 34 compared compare VBN cord-254317-n2knqj4z 389 35 with with IN cord-254317-n2knqj4z 389 36 its -PRON- PRP$ cord-254317-n2knqj4z 389 37 single single JJ cord-254317-n2knqj4z 389 38 infection infection NN cord-254317-n2knqj4z 389 39 in in IN cord-254317-n2knqj4z 389 40 pigs pig NNS cord-254317-n2knqj4z 389 41 . . . cord-254317-n2knqj4z 390 1 On on IN cord-254317-n2knqj4z 390 2 the the DT cord-254317-n2knqj4z 390 3 other other JJ cord-254317-n2knqj4z 390 4 hand hand NN cord-254317-n2knqj4z 390 5 , , , cord-254317-n2knqj4z 390 6 the the DT cord-254317-n2knqj4z 390 7 sensitivity sensitivity NN cord-254317-n2knqj4z 390 8 for for IN cord-254317-n2knqj4z 390 9 the the DT cord-254317-n2knqj4z 390 10 detection detection NN cord-254317-n2knqj4z 390 11 of of IN cord-254317-n2knqj4z 390 12 icPC22A icPC22A NNP cord-254317-n2knqj4z 390 13 - - HYPH cord-254317-n2knqj4z 390 14 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 390 15 decreased decrease VBD cord-254317-n2knqj4z 390 16 significantly significantly RB cord-254317-n2knqj4z 390 17 and and CC cord-254317-n2knqj4z 390 18 icPC22A icPC22A NNP cord-254317-n2knqj4z 390 19 - - HYPH cord-254317-n2knqj4z 390 20 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 390 21 became become VBD cord-254317-n2knqj4z 390 22 undetectable undetectable JJ cord-254317-n2knqj4z 390 23 when when WRB cord-254317-n2knqj4z 390 24 icPC22A icPC22A NNP cord-254317-n2knqj4z 390 25 was be VBD cord-254317-n2knqj4z 390 26 high high JJ cord-254317-n2knqj4z 390 27 ( ( -LRB- cord-254317-n2knqj4z 390 28 6.2 6.2 CD cord-254317-n2knqj4z 390 29 log log NN cord-254317-n2knqj4z 390 30 10 10 CD cord-254317-n2knqj4z 390 31 FFU FFU NNP cord-254317-n2knqj4z 390 32 / / SYM cord-254317-n2knqj4z 390 33 mL ml NN cord-254317-n2knqj4z 390 34 ) ) -RRB- cord-254317-n2knqj4z 390 35 and and CC cord-254317-n2knqj4z 390 36 icPC22 icpc22 NN cord-254317-n2knqj4z 391 1 A a LS cord-254317-n2knqj4z 391 2 - - HYPH cord-254317-n2knqj4z 391 3 S1Δ197 s1δ197 JJ cord-254317-n2knqj4z 391 4 infectious infectious JJ cord-254317-n2knqj4z 391 5 titers titer NNS cord-254317-n2knqj4z 391 6 were be VBD cord-254317-n2knqj4z 391 7 lower low JJR cord-254317-n2knqj4z 391 8 than than IN cord-254317-n2knqj4z 391 9 3.2 3.2 CD cord-254317-n2knqj4z 391 10 log log NN cord-254317-n2knqj4z 392 1 10 10 CD cord-254317-n2knqj4z 392 2 FFU FFU NNP cord-254317-n2knqj4z 392 3 / / SYM cord-254317-n2knqj4z 392 4 mL ml NN cord-254317-n2knqj4z 392 5 in in IN cord-254317-n2knqj4z 392 6 the the DT cord-254317-n2knqj4z 392 7 mixture mixture NN cord-254317-n2knqj4z 392 8 of of IN cord-254317-n2knqj4z 392 9 two two CD cord-254317-n2knqj4z 392 10 viruses virus NNS cord-254317-n2knqj4z 392 11 ( ( -LRB- cord-254317-n2knqj4z 392 12 Table Table NNP cord-254317-n2knqj4z 392 13 S2 S2 NNP cord-254317-n2knqj4z 392 14 ) ) -RRB- cord-254317-n2knqj4z 392 15 . . . cord-254317-n2knqj4z 393 1 Therefore therefore RB cord-254317-n2knqj4z 393 2 , , , cord-254317-n2knqj4z 393 3 the the DT cord-254317-n2knqj4z 393 4 decreased decreased JJ cord-254317-n2knqj4z 393 5 peak peak NN cord-254317-n2knqj4z 393 6 S S NNP cord-254317-n2knqj4z 393 7 gene gene NN cord-254317-n2knqj4z 393 8 titer titer NN cord-254317-n2knqj4z 393 9 ( ( -LRB- cord-254317-n2knqj4z 393 10 ∼5.8 ∼5.8 NNP cord-254317-n2knqj4z 393 11 log log VB cord-254317-n2knqj4z 393 12 10 10 CD cord-254317-n2knqj4z 393 13 copies copy NNS cord-254317-n2knqj4z 393 14 / / SYM cord-254317-n2knqj4z 393 15 mL ml NN cord-254317-n2knqj4z 393 16 ) ) -RRB- cord-254317-n2knqj4z 393 17 of of IN cord-254317-n2knqj4z 393 18 icPC22A icPC22A NNP cord-254317-n2knqj4z 393 19 - - HYPH cord-254317-n2knqj4z 393 20 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 393 21 in in IN cord-254317-n2knqj4z 393 22 coinfection coinfection NN cord-254317-n2knqj4z 393 23 of of IN cord-254317-n2knqj4z 393 24 pigs pig NNS cord-254317-n2knqj4z 393 25 compared compare VBN cord-254317-n2knqj4z 393 26 with with IN cord-254317-n2knqj4z 393 27 that that DT cord-254317-n2knqj4z 394 1 ( ( -LRB- cord-254317-n2knqj4z 394 2 ∼7.6 ∼7.6 TO cord-254317-n2knqj4z 394 3 log log VB cord-254317-n2knqj4z 394 4 10 10 CD cord-254317-n2knqj4z 394 5 copies copy NNS cord-254317-n2knqj4z 394 6 / / SYM cord-254317-n2knqj4z 394 7 mL ml NN cord-254317-n2knqj4z 394 8 ) ) -RRB- cord-254317-n2knqj4z 394 9 in in IN cord-254317-n2knqj4z 394 10 its -PRON- PRP$ cord-254317-n2knqj4z 394 11 single single JJ cord-254317-n2knqj4z 394 12 infection infection NN cord-254317-n2knqj4z 394 13 may may MD cord-254317-n2knqj4z 394 14 be be VB cord-254317-n2knqj4z 394 15 due due JJ cord-254317-n2knqj4z 394 16 to to IN cord-254317-n2knqj4z 394 17 inhibition inhibition NN cord-254317-n2knqj4z 394 18 of of IN cord-254317-n2knqj4z 394 19 replication replication NN cord-254317-n2knqj4z 394 20 or or CC cord-254317-n2knqj4z 394 21 the the DT cord-254317-n2knqj4z 394 22 decreased decrease VBN cord-254317-n2knqj4z 394 23 detection detection NN cord-254317-n2knqj4z 394 24 sensitivity sensitivity NN cord-254317-n2knqj4z 394 25 of of IN cord-254317-n2knqj4z 394 26 the the DT cord-254317-n2knqj4z 394 27 duplex duplex JJ cord-254317-n2knqj4z 394 28 RT rt NN cord-254317-n2knqj4z 394 29 - - HYPH cord-254317-n2knqj4z 394 30 qPCR qPCR NNP cord-254317-n2knqj4z 394 31 for for IN cord-254317-n2knqj4z 394 32 the the DT cord-254317-n2knqj4z 394 33 detection detection NN cord-254317-n2knqj4z 394 34 of of IN cord-254317-n2knqj4z 394 35 icPC22A icPC22A NNP cord-254317-n2knqj4z 394 36 - - HYPH cord-254317-n2knqj4z 394 37 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 394 38 during during IN cord-254317-n2knqj4z 394 39 coinfection coinfection NN cord-254317-n2knqj4z 394 40 ( ( -LRB- cord-254317-n2knqj4z 394 41 Table table NN cord-254317-n2knqj4z 394 42 2 2 CD cord-254317-n2knqj4z 394 43 ) ) -RRB- cord-254317-n2knqj4z 394 44 . . . cord-254317-n2knqj4z 395 1 In in IN cord-254317-n2knqj4z 395 2 the the DT cord-254317-n2knqj4z 395 3 first first JJ cord-254317-n2knqj4z 395 4 passage passage NN cord-254317-n2knqj4z 395 5 of of IN cord-254317-n2knqj4z 395 6 coinfection coinfection NN cord-254317-n2knqj4z 395 7 , , , cord-254317-n2knqj4z 395 8 we -PRON- PRP cord-254317-n2knqj4z 395 9 observed observe VBD cord-254317-n2knqj4z 395 10 much much RB cord-254317-n2knqj4z 395 11 lower low JJR cord-254317-n2knqj4z 395 12 numbers number NNS cord-254317-n2knqj4z 395 13 of of IN cord-254317-n2knqj4z 395 14 S1 S1 NNP cord-254317-n2knqj4z 395 15 NTD NTD NNP cord-254317-n2knqj4z 395 16 - - HYPH cord-254317-n2knqj4z 395 17 del del NNP cord-254317-n2knqj4z 395 18 PEDV PEDV NNP cord-254317-n2knqj4z 395 19 - - HYPH cord-254317-n2knqj4z 395 20 infected infect VBN cord-254317-n2knqj4z 395 21 cells cell NNS cord-254317-n2knqj4z 395 22 than than IN cord-254317-n2knqj4z 395 23 the the DT cord-254317-n2knqj4z 395 24 S s NN cord-254317-n2knqj4z 395 25 - - HYPH cord-254317-n2knqj4z 395 26 intact intact JJ cord-254317-n2knqj4z 395 27 PEDV PEDV NNP cord-254317-n2knqj4z 395 28 - - HYPH cord-254317-n2knqj4z 395 29 infected infect VBN cord-254317-n2knqj4z 395 30 cells cell NNS cord-254317-n2knqj4z 395 31 in in IN cord-254317-n2knqj4z 395 32 the the DT cord-254317-n2knqj4z 395 33 small small JJ cord-254317-n2knqj4z 395 34 intestines intestine NNS cord-254317-n2knqj4z 395 35 of of IN cord-254317-n2knqj4z 395 36 pigs pig NNS cord-254317-n2knqj4z 395 37 infected infect VBN cord-254317-n2knqj4z 395 38 with with IN cord-254317-n2knqj4z 395 39 the the DT cord-254317-n2knqj4z 395 40 same same JJ cord-254317-n2knqj4z 395 41 dose dose NN cord-254317-n2knqj4z 395 42 of of IN cord-254317-n2knqj4z 395 43 both both DT cord-254317-n2knqj4z 395 44 viruses virus NNS cord-254317-n2knqj4z 395 45 simultaneously simultaneously RB cord-254317-n2knqj4z 395 46 . . . cord-254317-n2knqj4z 396 1 In in IN cord-254317-n2knqj4z 396 2 addition addition NN cord-254317-n2knqj4z 396 3 , , , cord-254317-n2knqj4z 396 4 plaque plaque NN cord-254317-n2knqj4z 396 5 assays assay NNS cord-254317-n2knqj4z 396 6 were be VBD cord-254317-n2knqj4z 396 7 performed perform VBN cord-254317-n2knqj4z 396 8 to to TO cord-254317-n2knqj4z 396 9 isolate isolate VB cord-254317-n2knqj4z 396 10 and and CC cord-254317-n2knqj4z 396 11 purify purify VB cord-254317-n2knqj4z 396 12 individual individual JJ cord-254317-n2knqj4z 396 13 viruses virus NNS cord-254317-n2knqj4z 396 14 from from IN cord-254317-n2knqj4z 396 15 the the DT cord-254317-n2knqj4z 396 16 SIC sic NN cord-254317-n2knqj4z 396 17 of of IN cord-254317-n2knqj4z 396 18 one one CD cord-254317-n2knqj4z 396 19 of of IN cord-254317-n2knqj4z 396 20 the the DT cord-254317-n2knqj4z 396 21 coinfection coinfection NN cord-254317-n2knqj4z 396 22 pigs pig NNS cord-254317-n2knqj4z 396 23 . . . cord-254317-n2knqj4z 397 1 However however RB cord-254317-n2knqj4z 397 2 , , , cord-254317-n2knqj4z 397 3 only only RB cord-254317-n2knqj4z 397 4 S s NN cord-254317-n2knqj4z 397 5 - - HYPH cord-254317-n2knqj4z 397 6 intact intact JJ cord-254317-n2knqj4z 397 7 PEDV PEDV NNP cord-254317-n2knqj4z 397 8 was be VBD cord-254317-n2knqj4z 397 9 isolated isolate VBN cord-254317-n2knqj4z 397 10 alone alone RB cord-254317-n2knqj4z 397 11 . . . cord-254317-n2knqj4z 398 1 In in IN cord-254317-n2knqj4z 398 2 contrast contrast NN cord-254317-n2knqj4z 398 3 , , , cord-254317-n2knqj4z 398 4 S1 S1 NNP cord-254317-n2knqj4z 398 5 NTD NTD NNP cord-254317-n2knqj4z 398 6 - - HYPH cord-254317-n2knqj4z 398 7 del del NNP cord-254317-n2knqj4z 398 8 PEDV PEDV NNP cord-254317-n2knqj4z 398 9 was be VBD cord-254317-n2knqj4z 398 10 exclusively exclusively RB cord-254317-n2knqj4z 398 11 detected detect VBN cord-254317-n2knqj4z 398 12 together together RB cord-254317-n2knqj4z 398 13 with with IN cord-254317-n2knqj4z 398 14 the the DT cord-254317-n2knqj4z 398 15 Sintact Sintact NNP cord-254317-n2knqj4z 398 16 PEDV PEDV NNP cord-254317-n2knqj4z 398 17 from from IN cord-254317-n2knqj4z 398 18 the the DT cord-254317-n2knqj4z 398 19 plagues plague NNS cord-254317-n2knqj4z 398 20 . . . cord-254317-n2knqj4z 399 1 In in IN cord-254317-n2knqj4z 399 2 the the DT cord-254317-n2knqj4z 399 3 second second JJ cord-254317-n2knqj4z 399 4 passage passage NN cord-254317-n2knqj4z 399 5 of of IN cord-254317-n2knqj4z 399 6 the the DT cord-254317-n2knqj4z 399 7 coinfection coinfection NN cord-254317-n2knqj4z 399 8 in in IN cord-254317-n2knqj4z 399 9 pigs pig NNS cord-254317-n2knqj4z 399 10 , , , cord-254317-n2knqj4z 399 11 S s NN cord-254317-n2knqj4z 399 12 - - HYPH cord-254317-n2knqj4z 399 13 intact intact JJ cord-254317-n2knqj4z 399 14 PEDV PEDV NNP cord-254317-n2knqj4z 400 1 but but CC cord-254317-n2knqj4z 400 2 not not RB cord-254317-n2knqj4z 400 3 S1 s1 NN cord-254317-n2knqj4z 401 1 NTD NTD NNP cord-254317-n2knqj4z 401 2 - - HYPH cord-254317-n2knqj4z 401 3 del del NNP cord-254317-n2knqj4z 401 4 PEDV PEDV NNP cord-254317-n2knqj4z 401 5 RNA RNA NNP cord-254317-n2knqj4z 401 6 was be VBD cord-254317-n2knqj4z 401 7 detected detect VBN cord-254317-n2knqj4z 401 8 in in IN cord-254317-n2knqj4z 401 9 the the DT cord-254317-n2knqj4z 401 10 LIC LIC NNP cord-254317-n2knqj4z 401 11 of of IN cord-254317-n2knqj4z 401 12 the the DT cord-254317-n2knqj4z 401 13 pig pig NN cord-254317-n2knqj4z 401 14 inoculated inoculate VBN cord-254317-n2knqj4z 401 15 with with IN cord-254317-n2knqj4z 401 16 the the DT cord-254317-n2knqj4z 401 17 SIC sic NN cord-254317-n2knqj4z 401 18 of of IN cord-254317-n2knqj4z 401 19 the the DT cord-254317-n2knqj4z 401 20 pig pig NN cord-254317-n2knqj4z 401 21 inoculated inoculate VBN cord-254317-n2knqj4z 401 22 with with IN cord-254317-n2knqj4z 401 23 both both DT cord-254317-n2knqj4z 401 24 viruses virus NNS cord-254317-n2knqj4z 401 25 . . . cord-254317-n2knqj4z 402 1 This this DT cord-254317-n2knqj4z 402 2 finding finding NN cord-254317-n2knqj4z 402 3 suggests suggest VBZ cord-254317-n2knqj4z 402 4 that that IN cord-254317-n2knqj4z 402 5 S1 S1 NNP cord-254317-n2knqj4z 402 6 NTD NTD NNP cord-254317-n2knqj4z 402 7 - - HYPH cord-254317-n2knqj4z 402 8 del del NNP cord-254317-n2knqj4z 402 9 PEDV PEDV NNP cord-254317-n2knqj4z 402 10 had have VBD cord-254317-n2knqj4z 402 11 no no DT cord-254317-n2knqj4z 402 12 replication replication NN cord-254317-n2knqj4z 402 13 advantage advantage NN cord-254317-n2knqj4z 402 14 and and CC cord-254317-n2knqj4z 402 15 was be VBD cord-254317-n2knqj4z 402 16 either either CC cord-254317-n2knqj4z 402 17 outcompeted outcompete VBN cord-254317-n2knqj4z 402 18 or or CC cord-254317-n2knqj4z 402 19 coexisted coexist VBN cord-254317-n2knqj4z 402 20 with with IN cord-254317-n2knqj4z 402 21 Sintact Sintact NNP cord-254317-n2knqj4z 402 22 PEDV PEDV NNP cord-254317-n2knqj4z 402 23 in in IN cord-254317-n2knqj4z 402 24 pigs pig NNS cord-254317-n2knqj4z 402 25 . . . cord-254317-n2knqj4z 403 1 This this DT cord-254317-n2knqj4z 403 2 conclusion conclusion NN cord-254317-n2knqj4z 403 3 is be VBZ cord-254317-n2knqj4z 403 4 in in IN cord-254317-n2knqj4z 403 5 agreement agreement NN cord-254317-n2knqj4z 403 6 with with IN cord-254317-n2knqj4z 403 7 what what WP cord-254317-n2knqj4z 403 8 were be VBD cord-254317-n2knqj4z 403 9 observed observe VBN cord-254317-n2knqj4z 403 10 in in IN cord-254317-n2knqj4z 403 11 the the DT cord-254317-n2knqj4z 403 12 field field NN cord-254317-n2knqj4z 404 1 ( ( -LRB- cord-254317-n2knqj4z 404 2 Diep Diep NNP cord-254317-n2knqj4z 404 3 et et FW cord-254317-n2knqj4z 404 4 al al NNP cord-254317-n2knqj4z 404 5 . . NNP cord-254317-n2knqj4z 404 6 , , , cord-254317-n2knqj4z 404 7 2017 2017 CD cord-254317-n2knqj4z 404 8 ; ; . cord-254317-n2knqj4z 405 1 Su Su NNP cord-254317-n2knqj4z 405 2 et et FW cord-254317-n2knqj4z 405 3 al al NNP cord-254317-n2knqj4z 405 4 . . NNP cord-254317-n2knqj4z 405 5 , , , cord-254317-n2knqj4z 405 6 2018 2018 CD cord-254317-n2knqj4z 405 7 ) ) -RRB- cord-254317-n2knqj4z 405 8 . . . cord-254317-n2knqj4z 406 1 S1 S1 NNP cord-254317-n2knqj4z 406 2 NTD NTD NNP cord-254317-n2knqj4z 406 3 - - HYPH cord-254317-n2knqj4z 406 4 del del NNP cord-254317-n2knqj4z 406 5 PEDV PEDV NNP cord-254317-n2knqj4z 406 6 replicated replicate VBD cord-254317-n2knqj4z 406 7 to to IN cord-254317-n2knqj4z 406 8 a a DT cord-254317-n2knqj4z 406 9 lower low JJR cord-254317-n2knqj4z 406 10 peak peak NN cord-254317-n2knqj4z 406 11 titer titer NN cord-254317-n2knqj4z 406 12 in in IN cord-254317-n2knqj4z 406 13 coinfection coinfection NN cord-254317-n2knqj4z 406 14 than than IN cord-254317-n2knqj4z 406 15 that that DT cord-254317-n2knqj4z 406 16 in in IN cord-254317-n2knqj4z 406 17 single single JJ cord-254317-n2knqj4z 406 18 virus virus NN cord-254317-n2knqj4z 406 19 infection infection NN cord-254317-n2knqj4z 406 20 in in IN cord-254317-n2knqj4z 406 21 both both CC cord-254317-n2knqj4z 406 22 Vero Vero NNP cord-254317-n2knqj4z 406 23 cells cell NNS cord-254317-n2knqj4z 406 24 and and CC cord-254317-n2knqj4z 406 25 IPEC IPEC NNP cord-254317-n2knqj4z 406 26 - - HYPH cord-254317-n2knqj4z 406 27 DQ dq NN cord-254317-n2knqj4z 406 28 cells cell NNS cord-254317-n2knqj4z 406 29 . . . cord-254317-n2knqj4z 407 1 These these DT cord-254317-n2knqj4z 407 2 in in IN cord-254317-n2knqj4z 407 3 vitro vitro FW cord-254317-n2knqj4z 407 4 results result NNS cord-254317-n2knqj4z 407 5 were be VBD cord-254317-n2knqj4z 407 6 similar similar JJ cord-254317-n2knqj4z 407 7 to to IN cord-254317-n2knqj4z 407 8 those those DT cord-254317-n2knqj4z 407 9 in in IN cord-254317-n2knqj4z 407 10 the the DT cord-254317-n2knqj4z 407 11 pig pig NN cord-254317-n2knqj4z 407 12 studies study NNS cord-254317-n2knqj4z 407 13 . . . cord-254317-n2knqj4z 408 1 In in IN cord-254317-n2knqj4z 408 2 the the DT cord-254317-n2knqj4z 408 3 second second JJ cord-254317-n2knqj4z 408 4 passage passage NN cord-254317-n2knqj4z 408 5 of of IN cord-254317-n2knqj4z 408 6 coinfection coinfection NN cord-254317-n2knqj4z 408 7 , , , cord-254317-n2knqj4z 408 8 S1 S1 NNP cord-254317-n2knqj4z 408 9 NTD NTD NNP cord-254317-n2knqj4z 408 10 - - HYPH cord-254317-n2knqj4z 408 11 del del NNP cord-254317-n2knqj4z 408 12 PEDV PEDV NNP cord-254317-n2knqj4z 408 13 RNA RNA NNP cord-254317-n2knqj4z 408 14 was be VBD cord-254317-n2knqj4z 408 15 detected detect VBN cord-254317-n2knqj4z 408 16 in in IN cord-254317-n2knqj4z 408 17 Vero Vero NNP cord-254317-n2knqj4z 408 18 cells cell NNS cord-254317-n2knqj4z 408 19 but but CC cord-254317-n2knqj4z 408 20 not not RB cord-254317-n2knqj4z 408 21 in in IN cord-254317-n2knqj4z 408 22 IPEC IPEC NNP cord-254317-n2knqj4z 408 23 - - HYPH cord-254317-n2knqj4z 408 24 DQ dq NN cord-254317-n2knqj4z 408 25 cells cell NNS cord-254317-n2knqj4z 408 26 , , , cord-254317-n2knqj4z 408 27 probably probably RB cord-254317-n2knqj4z 408 28 due due IN cord-254317-n2knqj4z 408 29 to to IN cord-254317-n2knqj4z 408 30 the the DT cord-254317-n2knqj4z 408 31 lower low JJR cord-254317-n2knqj4z 408 32 replication replication NN cord-254317-n2knqj4z 408 33 efficiency efficiency NN cord-254317-n2knqj4z 408 34 of of IN cord-254317-n2knqj4z 408 35 the the DT cord-254317-n2knqj4z 408 36 S1 S1 NNP cord-254317-n2knqj4z 408 37 NTD NTD NNP cord-254317-n2knqj4z 408 38 - - HYPH cord-254317-n2knqj4z 408 39 del del NNP cord-254317-n2knqj4z 408 40 PEDV PEDV NNP cord-254317-n2knqj4z 408 41 in in IN cord-254317-n2knqj4z 408 42 IPEC IPEC NNP cord-254317-n2knqj4z 408 43 - - HYPH cord-254317-n2knqj4z 408 44 DQ dq NN cord-254317-n2knqj4z 408 45 cells cell NNS cord-254317-n2knqj4z 408 46 than than IN cord-254317-n2knqj4z 408 47 in in IN cord-254317-n2knqj4z 408 48 Vero Vero NNP cord-254317-n2knqj4z 408 49 cells cell NNS cord-254317-n2knqj4z 408 50 ( ( -LRB- cord-254317-n2knqj4z 408 51 Fig Fig NNP cord-254317-n2knqj4z 408 52 . . . cord-254317-n2knqj4z 408 53 3A 3A NNP cord-254317-n2knqj4z 408 54 and and CC cord-254317-n2knqj4z 408 55 C C NNP cord-254317-n2knqj4z 408 56 ) ) -RRB- cord-254317-n2knqj4z 408 57 . . . cord-254317-n2knqj4z 409 1 Similar similar JJ cord-254317-n2knqj4z 409 2 to to IN cord-254317-n2knqj4z 409 3 other other JJ cord-254317-n2knqj4z 409 4 sialic sialic JJ cord-254317-n2knqj4z 409 5 acid acid NN cord-254317-n2knqj4z 409 6 - - HYPH cord-254317-n2knqj4z 409 7 binding bind VBG cord-254317-n2knqj4z 409 8 coronaviruses coronaviruse NNS cord-254317-n2knqj4z 409 9 , , , cord-254317-n2knqj4z 409 10 the the DT cord-254317-n2knqj4z 409 11 S1 S1 NNP cord-254317-n2knqj4z 409 12 NTD NTD NNP cord-254317-n2knqj4z 409 13 of of IN cord-254317-n2knqj4z 409 14 PEDV PEDV NNP cord-254317-n2knqj4z 409 15 has have VBZ cord-254317-n2knqj4z 409 16 a a DT cord-254317-n2knqj4z 409 17 sialic sialic JJ cord-254317-n2knqj4z 409 18 acid acid NN cord-254317-n2knqj4z 409 19 binding binding NN cord-254317-n2knqj4z 409 20 activity activity NN cord-254317-n2knqj4z 409 21 , , , cord-254317-n2knqj4z 409 22 and and CC cord-254317-n2knqj4z 409 23 the the DT cord-254317-n2knqj4z 409 24 sugar sugar NN cord-254317-n2knqj4z 409 25 - - HYPH cord-254317-n2knqj4z 409 26 binding bind VBG cord-254317-n2knqj4z 409 27 activities activity NNS cord-254317-n2knqj4z 409 28 of of IN cord-254317-n2knqj4z 409 29 a a DT cord-254317-n2knqj4z 409 30 field field NN cord-254317-n2knqj4z 409 31 isolate isolate VBP cord-254317-n2knqj4z 409 32 PEDV PEDV NNP cord-254317-n2knqj4z 409 33 variant variant NN cord-254317-n2knqj4z 409 34 CHGD-01 CHGD-01 NNPS cord-254317-n2knqj4z 409 35 was be VBD cord-254317-n2knqj4z 409 36 stronger strong JJR cord-254317-n2knqj4z 409 37 than than IN cord-254317-n2knqj4z 409 38 that that DT cord-254317-n2knqj4z 409 39 of of IN cord-254317-n2knqj4z 409 40 the the DT cord-254317-n2knqj4z 409 41 prototype prototype NN cord-254317-n2knqj4z 409 42 strain strain NN cord-254317-n2knqj4z 409 43 PEDV PEDV NNP cord-254317-n2knqj4z 409 44 CV777 CV777 NNP cord-254317-n2knqj4z 409 45 using use VBG cord-254317-n2knqj4z 409 46 BM BM NNP cord-254317-n2knqj4z 409 47 ( ( -LRB- cord-254317-n2knqj4z 409 48 Deng Deng NNP cord-254317-n2knqj4z 409 49 et et FW cord-254317-n2knqj4z 409 50 al al NNP cord-254317-n2knqj4z 409 51 . . NNP cord-254317-n2knqj4z 409 52 , , , cord-254317-n2knqj4z 409 53 2016 2016 CD cord-254317-n2knqj4z 409 54 ) ) -RRB- cord-254317-n2knqj4z 409 55 . . . cord-254317-n2knqj4z 410 1 The the DT cord-254317-n2knqj4z 410 2 sialic sialic JJ cord-254317-n2knqj4z 410 3 acid acid NN cord-254317-n2knqj4z 410 4 binding bind VBG cord-254317-n2knqj4z 410 5 activity activity NN cord-254317-n2knqj4z 410 6 occurred occur VBD cord-254317-n2knqj4z 410 7 within within IN cord-254317-n2knqj4z 410 8 the the DT cord-254317-n2knqj4z 410 9 N n CD cord-254317-n2knqj4z 410 10 - - HYPH cord-254317-n2knqj4z 410 11 terminal terminal JJ cord-254317-n2knqj4z 410 12 249 249 CD cord-254317-n2knqj4z 410 13 residues residue NNS cord-254317-n2knqj4z 410 14 and and CC cord-254317-n2knqj4z 410 15 the the DT cord-254317-n2knqj4z 410 16 capacity capacity NN cord-254317-n2knqj4z 410 17 of of IN cord-254317-n2knqj4z 410 18 sialic sialic JJ cord-254317-n2knqj4z 410 19 acid acid NN cord-254317-n2knqj4z 410 20 binding binding NN cord-254317-n2knqj4z 410 21 differs differ VBZ cord-254317-n2knqj4z 410 22 among among IN cord-254317-n2knqj4z 410 23 PEDV PEDV NNP cord-254317-n2knqj4z 410 24 strains strain NNS cord-254317-n2knqj4z 410 25 using use VBG cord-254317-n2knqj4z 410 26 an an DT cord-254317-n2knqj4z 410 27 hemagglutination hemagglutination NN cord-254317-n2knqj4z 410 28 assay assay NN cord-254317-n2knqj4z 410 29 . . . cord-254317-n2knqj4z 411 1 The the DT cord-254317-n2knqj4z 411 2 recombinant recombinant JJ cord-254317-n2knqj4z 411 3 virus virus NN cord-254317-n2knqj4z 411 4 used use VBN cord-254317-n2knqj4z 411 5 in in IN cord-254317-n2knqj4z 411 6 this this DT cord-254317-n2knqj4z 411 7 study study NN cord-254317-n2knqj4z 411 8 , , , cord-254317-n2knqj4z 411 9 PEDV PEDV NNP cord-254317-n2knqj4z 411 10 icPC22 icpc22 NN cord-254317-n2knqj4z 412 1 A a LS cord-254317-n2knqj4z 412 2 - - HYPH cord-254317-n2knqj4z 412 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 412 4 , , , cord-254317-n2knqj4z 412 5 is be VBZ cord-254317-n2knqj4z 412 6 a a DT cord-254317-n2knqj4z 412 7 S1 S1 NNP cord-254317-n2knqj4z 412 8 NTD NTD NNP cord-254317-n2knqj4z 412 9 - - HYPH cord-254317-n2knqj4z 412 10 del del NNP cord-254317-n2knqj4z 412 11 version version NN cord-254317-n2knqj4z 412 12 of of IN cord-254317-n2knqj4z 412 13 icPC22A. icPC22A. NNP cord-254317-n2knqj4z 413 1 It -PRON- PRP cord-254317-n2knqj4z 413 2 lost lose VBD cord-254317-n2knqj4z 413 3 most most JJS cord-254317-n2knqj4z 413 4 sialic sialic JJ cord-254317-n2knqj4z 413 5 acid acid NN cord-254317-n2knqj4z 413 6 binding bind VBG cord-254317-n2knqj4z 413 7 activity activity NN cord-254317-n2knqj4z 413 8 tested test VBN cord-254317-n2knqj4z 413 9 in in IN cord-254317-n2knqj4z 413 10 Vero Vero NNP cord-254317-n2knqj4z 413 11 cells cell NNS cord-254317-n2knqj4z 413 12 ( ( -LRB- cord-254317-n2knqj4z 414 1 Hou Hou NNP cord-254317-n2knqj4z 414 2 et et NNP cord-254317-n2knqj4z 414 3 al al NNP cord-254317-n2knqj4z 414 4 . . NNP cord-254317-n2knqj4z 414 5 , , , cord-254317-n2knqj4z 414 6 2017 2017 CD cord-254317-n2knqj4z 414 7 ) ) -RRB- cord-254317-n2knqj4z 414 8 . . . cord-254317-n2knqj4z 415 1 In in IN cord-254317-n2knqj4z 415 2 this this DT cord-254317-n2knqj4z 415 3 study study NN cord-254317-n2knqj4z 415 4 , , , cord-254317-n2knqj4z 415 5 we -PRON- PRP cord-254317-n2knqj4z 415 6 comparatively comparatively RB cord-254317-n2knqj4z 415 7 tested test VBD cord-254317-n2knqj4z 415 8 icPC22 icpc22 CD cord-254317-n2knqj4z 416 1 A a LS cord-254317-n2knqj4z 416 2 - - HYPH cord-254317-n2knqj4z 416 3 S1Δ197 s1δ197 NN cord-254317-n2knqj4z 416 4 and and CC cord-254317-n2knqj4z 416 5 icPC22 icpc22 NN cord-254317-n2knqj4z 417 1 A a DT cord-254317-n2knqj4z 417 2 in in IN cord-254317-n2knqj4z 417 3 Vero Vero NNP cord-254317-n2knqj4z 417 4 and and CC cord-254317-n2knqj4z 417 5 IPEC IPEC NNP cord-254317-n2knqj4z 417 6 - - HYPH cord-254317-n2knqj4z 417 7 DQ dq NN cord-254317-n2knqj4z 417 8 cells cell NNS cord-254317-n2knqj4z 417 9 treated treat VBN cord-254317-n2knqj4z 417 10 with with IN cord-254317-n2knqj4z 417 11 NA NA NNP cord-254317-n2knqj4z 417 12 . . . cord-254317-n2knqj4z 418 1 Similar similar JJ cord-254317-n2knqj4z 418 2 to to IN cord-254317-n2knqj4z 418 3 the the DT cord-254317-n2knqj4z 418 4 previous previous JJ cord-254317-n2knqj4z 418 5 reports report NNS cord-254317-n2knqj4z 418 6 , , , cord-254317-n2knqj4z 418 7 our -PRON- PRP$ cord-254317-n2knqj4z 418 8 results result NNS cord-254317-n2knqj4z 418 9 confirmed confirm VBD cord-254317-n2knqj4z 418 10 that that IN cord-254317-n2knqj4z 418 11 the the DT cord-254317-n2knqj4z 418 12 binding binding NN cord-254317-n2knqj4z 418 13 of of IN cord-254317-n2knqj4z 418 14 S1 S1 NNP cord-254317-n2knqj4z 418 15 NTD NTD NNP cord-254317-n2knqj4z 418 16 of of IN cord-254317-n2knqj4z 418 17 PEDV PEDV NNP cord-254317-n2knqj4z 418 18 to to IN cord-254317-n2knqj4z 418 19 sialic sialic JJ cord-254317-n2knqj4z 418 20 acids acid NNS cord-254317-n2knqj4z 418 21 on on IN cord-254317-n2knqj4z 418 22 cell cell NN cord-254317-n2knqj4z 418 23 surface surface NN cord-254317-n2knqj4z 418 24 enhanced enhance VBN cord-254317-n2knqj4z 418 25 virus virus NN cord-254317-n2knqj4z 418 26 infectivity infectivity NN cord-254317-n2knqj4z 418 27 . . . cord-254317-n2knqj4z 419 1 BM BM NNP cord-254317-n2knqj4z 419 2 is be VBZ cord-254317-n2knqj4z 419 3 a a DT cord-254317-n2knqj4z 419 4 mixture mixture NN cord-254317-n2knqj4z 419 5 of of IN cord-254317-n2knqj4z 419 6 highly highly RB cord-254317-n2knqj4z 419 7 glycosylated glycosylated JJ cord-254317-n2knqj4z 419 8 proteins protein NNS cord-254317-n2knqj4z 419 9 containing contain VBG cord-254317-n2knqj4z 419 10 sugar sugar NN cord-254317-n2knqj4z 419 11 moieties moiety NNS cord-254317-n2knqj4z 419 12 , , , cord-254317-n2knqj4z 419 13 such such JJ cord-254317-n2knqj4z 419 14 as as IN cord-254317-n2knqj4z 419 15 5-N 5-n CD cord-254317-n2knqj4z 419 16 - - HYPH cord-254317-n2knqj4z 419 17 acetyl-9-O acetyl-9-o NN cord-254317-n2knqj4z 419 18 - - HYPH cord-254317-n2knqj4z 419 19 acetylneuraminic acetylneuraminic JJ cord-254317-n2knqj4z 419 20 acid acid NN cord-254317-n2knqj4z 419 21 ( ( -LRB- cord-254317-n2knqj4z 419 22 Neu5,9Ac2 Neu5,9Ac2 NNP cord-254317-n2knqj4z 419 23 ) ) -RRB- cord-254317-n2knqj4z 419 24 , , , cord-254317-n2knqj4z 419 25 5-N 5-n CD cord-254317-n2knqj4z 419 26 - - HYPH cord-254317-n2knqj4z 419 27 glycolylneuraminic glycolylneuraminic NN cord-254317-n2knqj4z 419 28 acid acid NN cord-254317-n2knqj4z 419 29 ( ( -LRB- cord-254317-n2knqj4z 419 30 Neu5Gc Neu5Gc NNP cord-254317-n2knqj4z 419 31 ) ) -RRB- cord-254317-n2knqj4z 419 32 , , , cord-254317-n2knqj4z 419 33 and and CC cord-254317-n2knqj4z 419 34 5-N 5-n CD cord-254317-n2knqj4z 419 35 - - HYPH cord-254317-n2knqj4z 419 36 acetylneuraminic acetylneuraminic JJ cord-254317-n2knqj4z 419 37 acid acid NN cord-254317-n2knqj4z 419 38 ( ( -LRB- cord-254317-n2knqj4z 419 39 Neu5Ac Neu5Ac NNP cord-254317-n2knqj4z 419 40 ) ) -RRB- cord-254317-n2knqj4z 419 41 . . . cord-254317-n2knqj4z 420 1 Among among IN cord-254317-n2knqj4z 420 2 them -PRON- PRP cord-254317-n2knqj4z 420 3 , , , cord-254317-n2knqj4z 420 4 Neu5Gc Neu5Gc NNPS cord-254317-n2knqj4z 420 5 and and CC cord-254317-n2knqj4z 420 6 Neu5Ac Neu5Ac NNP cord-254317-n2knqj4z 420 7 can can MD cord-254317-n2knqj4z 420 8 serve serve VB cord-254317-n2knqj4z 420 9 as as IN cord-254317-n2knqj4z 420 10 receptors receptor NNS cord-254317-n2knqj4z 420 11 or or CC cord-254317-n2knqj4z 420 12 co co NNS cord-254317-n2knqj4z 420 13 - - NNS cord-254317-n2knqj4z 420 14 receptors receptor NNS cord-254317-n2knqj4z 420 15 for for IN cord-254317-n2knqj4z 420 16 some some DT cord-254317-n2knqj4z 420 17 alphacoronaviruses alphacoronaviruse NNS cord-254317-n2knqj4z 420 18 ( ( -LRB- cord-254317-n2knqj4z 420 19 e.g. e.g. RB cord-254317-n2knqj4z 420 20 , , , cord-254317-n2knqj4z 420 21 TGEV TGEV NNP cord-254317-n2knqj4z 420 22 ) ) -RRB- cord-254317-n2knqj4z 420 23 and and CC cord-254317-n2knqj4z 420 24 gammacoronaviruses gammacoronaviruse NNS cord-254317-n2knqj4z 420 25 [ [ -LRB- cord-254317-n2knqj4z 420 26 e.g. e.g. RB cord-254317-n2knqj4z 420 27 , , , cord-254317-n2knqj4z 420 28 infectious infectious JJ cord-254317-n2knqj4z 420 29 bronchitis bronchitis NN cord-254317-n2knqj4z 420 30 virus virus NN cord-254317-n2knqj4z 420 31 ( ( -LRB- cord-254317-n2knqj4z 420 32 IBV IBV NNP cord-254317-n2knqj4z 420 33 ) ) -RRB- cord-254317-n2knqj4z 420 34 ] ] -RRB- cord-254317-n2knqj4z 421 1 ( ( -LRB- cord-254317-n2knqj4z 421 2 Cavanagh Cavanagh NNP cord-254317-n2knqj4z 421 3 and and CC cord-254317-n2knqj4z 421 4 Davis Davis NNP cord-254317-n2knqj4z 421 5 , , , cord-254317-n2knqj4z 421 6 1986 1986 CD cord-254317-n2knqj4z 421 7 ; ; : cord-254317-n2knqj4z 421 8 Krempl Krempl NNP cord-254317-n2knqj4z 421 9 et et NNP cord-254317-n2knqj4z 421 10 al al NNP cord-254317-n2knqj4z 421 11 . . NNP cord-254317-n2knqj4z 421 12 , , , cord-254317-n2knqj4z 421 13 1997 1997 CD cord-254317-n2knqj4z 421 14 ) ) -RRB- cord-254317-n2knqj4z 421 15 . . . cord-254317-n2knqj4z 422 1 Similar similar JJ cord-254317-n2knqj4z 422 2 to to IN cord-254317-n2knqj4z 422 3 TGEV TGEV NNP cord-254317-n2knqj4z 422 4 , , , cord-254317-n2knqj4z 422 5 which which WDT cord-254317-n2knqj4z 422 6 uses use VBZ cord-254317-n2knqj4z 422 7 Neu5Gc Neu5Gc NNP cord-254317-n2knqj4z 422 8 and and CC cord-254317-n2knqj4z 422 9 Neu5 Neu5 NNP cord-254317-n2knqj4z 422 10 Ac Ac NNP cord-254317-n2knqj4z 422 11 as as IN cord-254317-n2knqj4z 422 12 co co NNS cord-254317-n2knqj4z 422 13 - - NNS cord-254317-n2knqj4z 422 14 receptors receptor NNS cord-254317-n2knqj4z 422 15 ( ( -LRB- cord-254317-n2knqj4z 422 16 Krempl Krempl NNP cord-254317-n2knqj4z 422 17 et et FW cord-254317-n2knqj4z 422 18 al al NNP cord-254317-n2knqj4z 422 19 . . NNP cord-254317-n2knqj4z 422 20 , , , cord-254317-n2knqj4z 422 21 1997 1997 CD cord-254317-n2knqj4z 422 22 ; ; . cord-254317-n2knqj4z 423 1 Schultze Schultze NNP cord-254317-n2knqj4z 423 2 et et NNP cord-254317-n2knqj4z 423 3 al al NNP cord-254317-n2knqj4z 423 4 . . NNP cord-254317-n2knqj4z 423 5 , , , cord-254317-n2knqj4z 423 6 1996 1996 CD cord-254317-n2knqj4z 423 7 ; ; : cord-254317-n2knqj4z 423 8 Schwegmann Schwegmann NNP cord-254317-n2knqj4z 423 9 - - HYPH cord-254317-n2knqj4z 423 10 Wessels Wessels NNP cord-254317-n2knqj4z 423 11 and and CC cord-254317-n2knqj4z 423 12 Herrler Herrler NNP cord-254317-n2knqj4z 423 13 , , , cord-254317-n2knqj4z 423 14 2006 2006 CD cord-254317-n2knqj4z 423 15 ) ) -RRB- cord-254317-n2knqj4z 424 1 , , , cord-254317-n2knqj4z 424 2 the the DT cord-254317-n2knqj4z 424 3 S1 S1 NNP cord-254317-n2knqj4z 424 4 NTD NTD NNP cord-254317-n2knqj4z 424 5 of of IN cord-254317-n2knqj4z 424 6 PEDV PEDV NNP cord-254317-n2knqj4z 424 7 interacted interact VBD cord-254317-n2knqj4z 424 8 with with IN cord-254317-n2knqj4z 424 9 sugar sugar NN cord-254317-n2knqj4z 424 10 ( ( -LRB- cord-254317-n2knqj4z 425 1 Deng Deng NNP cord-254317-n2knqj4z 425 2 et et NNP cord-254317-n2knqj4z 425 3 al al NNP cord-254317-n2knqj4z 425 4 . . NNP cord-254317-n2knqj4z 425 5 , , , cord-254317-n2knqj4z 425 6 2016 2016 CD cord-254317-n2knqj4z 425 7 ) ) -RRB- cord-254317-n2knqj4z 425 8 . . . cord-254317-n2knqj4z 426 1 PGM PGM NNP cord-254317-n2knqj4z 426 2 contains contain VBZ cord-254317-n2knqj4z 426 3 0.5 0.5 CD cord-254317-n2knqj4z 426 4 - - SYM cord-254317-n2knqj4z 426 5 1.5 1.5 CD cord-254317-n2knqj4z 426 6 % % NN cord-254317-n2knqj4z 426 7 N n CD cord-254317-n2knqj4z 426 8 - - HYPH cord-254317-n2knqj4z 426 9 Acetylneuraminic Acetylneuraminic NNP cord-254317-n2knqj4z 426 10 acid acid NN cord-254317-n2knqj4z 426 11 ( ( -LRB- cord-254317-n2knqj4z 426 12 NeuAc NeuAc NNP cord-254317-n2knqj4z 426 13 ) ) -RRB- cord-254317-n2knqj4z 426 14 . . . cord-254317-n2knqj4z 427 1 Our -PRON- PRP$ cord-254317-n2knqj4z 427 2 data datum NNS cord-254317-n2knqj4z 427 3 indicated indicate VBD cord-254317-n2knqj4z 427 4 that that IN cord-254317-n2knqj4z 427 5 low low JJ cord-254317-n2knqj4z 427 6 - - HYPH cord-254317-n2knqj4z 427 7 medium medium NN cord-254317-n2knqj4z 427 8 concentrations concentration NNS cord-254317-n2knqj4z 427 9 of of IN cord-254317-n2knqj4z 427 10 BM BM NNP cord-254317-n2knqj4z 427 11 or or CC cord-254317-n2knqj4z 427 12 PGM PGM NNP cord-254317-n2knqj4z 427 13 enhanced enhance VBD cord-254317-n2knqj4z 427 14 the the DT cord-254317-n2knqj4z 427 15 infectivity infectivity NN cord-254317-n2knqj4z 427 16 of of IN cord-254317-n2knqj4z 427 17 S s NN cord-254317-n2knqj4z 427 18 - - HYPH cord-254317-n2knqj4z 427 19 intact intact JJ cord-254317-n2knqj4z 427 20 PEDV PEDV NNP cord-254317-n2knqj4z 427 21 in in IN cord-254317-n2knqj4z 427 22 both both CC cord-254317-n2knqj4z 427 23 Vero Vero NNP cord-254317-n2knqj4z 427 24 and and CC cord-254317-n2knqj4z 427 25 IPEC IPEC NNP cord-254317-n2knqj4z 427 26 - - HYPH cord-254317-n2knqj4z 427 27 DQ dq NN cord-254317-n2knqj4z 427 28 cells cell NNS cord-254317-n2knqj4z 427 29 . . . cord-254317-n2knqj4z 428 1 In in IN cord-254317-n2knqj4z 428 2 contrast contrast NN cord-254317-n2knqj4z 428 3 , , , cord-254317-n2knqj4z 428 4 the the DT cord-254317-n2knqj4z 428 5 S1 S1 NNP cord-254317-n2knqj4z 428 6 NTD NTD NNP cord-254317-n2knqj4z 428 7 - - HYPH cord-254317-n2knqj4z 428 8 del del NNP cord-254317-n2knqj4z 428 9 PEDV PEDV NNP cord-254317-n2knqj4z 428 10 was be VBD cord-254317-n2knqj4z 428 11 not not RB cord-254317-n2knqj4z 428 12 affected affect VBN cord-254317-n2knqj4z 428 13 or or CC cord-254317-n2knqj4z 428 14 inhibited inhibit VBN cord-254317-n2knqj4z 428 15 , , , cord-254317-n2knqj4z 428 16 probably probably RB cord-254317-n2knqj4z 428 17 due due IN cord-254317-n2knqj4z 428 18 to to IN cord-254317-n2knqj4z 428 19 the the DT cord-254317-n2knqj4z 428 20 covered covered JJ cord-254317-n2knqj4z 428 21 mucin mucin NN cord-254317-n2knqj4z 428 22 that that WDT cord-254317-n2knqj4z 428 23 blocked block VBD cord-254317-n2knqj4z 428 24 virus virus NN cord-254317-n2knqj4z 428 25 binding bind VBG cord-254317-n2knqj4z 428 26 to to IN cord-254317-n2knqj4z 428 27 the the DT cord-254317-n2knqj4z 428 28 receptors receptor NNS cord-254317-n2knqj4z 428 29 . . . cord-254317-n2knqj4z 429 1 The the DT cord-254317-n2knqj4z 429 2 intestinal intestinal JJ cord-254317-n2knqj4z 429 3 epithelial epithelial JJ cord-254317-n2knqj4z 429 4 cells cell NNS cord-254317-n2knqj4z 429 5 are be VBP cord-254317-n2knqj4z 429 6 covered cover VBN cord-254317-n2knqj4z 429 7 by by IN cord-254317-n2knqj4z 429 8 a a DT cord-254317-n2knqj4z 429 9 layer layer NN cord-254317-n2knqj4z 429 10 of of IN cord-254317-n2knqj4z 429 11 mucus mucus NN cord-254317-n2knqj4z 429 12 that that WDT cord-254317-n2knqj4z 429 13 is be VBZ cord-254317-n2knqj4z 429 14 rich rich JJ cord-254317-n2knqj4z 429 15 in in IN cord-254317-n2knqj4z 429 16 sialic sialic JJ cord-254317-n2knqj4z 429 17 acids acid NNS cord-254317-n2knqj4z 429 18 . . . cord-254317-n2knqj4z 430 1 These these DT cord-254317-n2knqj4z 430 2 results result NNS cord-254317-n2knqj4z 430 3 suggest suggest VBP cord-254317-n2knqj4z 430 4 that that IN cord-254317-n2knqj4z 430 5 low low JJ cord-254317-n2knqj4z 430 6 - - HYPH cord-254317-n2knqj4z 430 7 medium medium NN cord-254317-n2knqj4z 430 8 amount amount NN cord-254317-n2knqj4z 430 9 of of IN cord-254317-n2knqj4z 430 10 mucin mucin NN cord-254317-n2knqj4z 430 11 binding bind VBG cord-254317-n2knqj4z 430 12 to to IN cord-254317-n2knqj4z 430 13 S s NN cord-254317-n2knqj4z 430 14 - - HYPH cord-254317-n2knqj4z 430 15 intact intact JJ cord-254317-n2knqj4z 430 16 PEDV PEDV NNP cord-254317-n2knqj4z 430 17 may may MD cord-254317-n2knqj4z 430 18 help help VB cord-254317-n2knqj4z 430 19 the the DT cord-254317-n2knqj4z 430 20 virus virus NN cord-254317-n2knqj4z 430 21 particles particle NNS cord-254317-n2knqj4z 430 22 approach approach VBP cord-254317-n2knqj4z 430 23 the the DT cord-254317-n2knqj4z 430 24 receptors receptor NNS cord-254317-n2knqj4z 430 25 via via IN cord-254317-n2knqj4z 430 26 sticking stick VBG cord-254317-n2knqj4z 430 27 to to IN cord-254317-n2knqj4z 430 28 the the DT cord-254317-n2knqj4z 430 29 sialic sialic JJ cord-254317-n2knqj4z 430 30 acids acid NNS cord-254317-n2knqj4z 430 31 on on IN cord-254317-n2knqj4z 430 32 the the DT cord-254317-n2knqj4z 430 33 cell cell NN cord-254317-n2knqj4z 430 34 surface surface NN cord-254317-n2knqj4z 430 35 . . . cord-254317-n2knqj4z 431 1 However however RB cord-254317-n2knqj4z 431 2 , , , cord-254317-n2knqj4z 431 3 the the DT cord-254317-n2knqj4z 431 4 receptor receptor NN cord-254317-n2knqj4z 431 5 binding bind VBG cord-254317-n2knqj4z 431 6 domain domain NN cord-254317-n2knqj4z 431 7 ( ( -LRB- cord-254317-n2knqj4z 431 8 RBD RBD NNP cord-254317-n2knqj4z 431 9 ) ) -RRB- cord-254317-n2knqj4z 431 10 on on IN cord-254317-n2knqj4z 431 11 the the DT cord-254317-n2knqj4z 431 12 S S NNP cord-254317-n2knqj4z 431 13 protein protein NN cord-254317-n2knqj4z 431 14 of of IN cord-254317-n2knqj4z 431 15 S1 S1 NNP cord-254317-n2knqj4z 431 16 NTD NTD NNP cord-254317-n2knqj4z 431 17 - - HYPH cord-254317-n2knqj4z 431 18 del del NNP cord-254317-n2knqj4z 431 19 PEDV PEDV NNP cord-254317-n2knqj4z 431 20 , , , cord-254317-n2knqj4z 431 21 which which WDT cord-254317-n2knqj4z 431 22 lacks lack VBZ cord-254317-n2knqj4z 431 23 most most JJS cord-254317-n2knqj4z 431 24 sialic sialic JJ cord-254317-n2knqj4z 431 25 acid acid NN cord-254317-n2knqj4z 431 26 binding bind VBG cord-254317-n2knqj4z 431 27 activity activity NN cord-254317-n2knqj4z 431 28 , , , cord-254317-n2knqj4z 431 29 is be VBZ cord-254317-n2knqj4z 431 30 probably probably RB cord-254317-n2knqj4z 431 31 covered cover VBN cord-254317-n2knqj4z 431 32 with with IN cord-254317-n2knqj4z 431 33 mucin mucin NN cord-254317-n2knqj4z 431 34 and and CC cord-254317-n2knqj4z 431 35 blocked block VBD cord-254317-n2knqj4z 431 36 its -PRON- PRP$ cord-254317-n2knqj4z 431 37 binding binding NN cord-254317-n2knqj4z 431 38 to to IN cord-254317-n2knqj4z 431 39 the the DT cord-254317-n2knqj4z 431 40 receptors receptor NNS cord-254317-n2knqj4z 431 41 . . . cord-254317-n2knqj4z 432 1 When when WRB cord-254317-n2knqj4z 432 2 high high JJ cord-254317-n2knqj4z 432 3 concentration concentration NN cord-254317-n2knqj4z 432 4 of of IN cord-254317-n2knqj4z 432 5 mucin mucin NN cord-254317-n2knqj4z 432 6 saturates saturate VBZ cord-254317-n2knqj4z 432 7 the the DT cord-254317-n2knqj4z 432 8 S1 S1 NNP cord-254317-n2knqj4z 432 9 NTD NTD NNP cord-254317-n2knqj4z 432 10 of of IN cord-254317-n2knqj4z 432 11 S S NNP cord-254317-n2knqj4z 432 12 - - HYPH cord-254317-n2knqj4z 432 13 intact intact JJ cord-254317-n2knqj4z 432 14 PEDV PEDV NNP cord-254317-n2knqj4z 432 15 , , , cord-254317-n2knqj4z 432 16 it -PRON- PRP cord-254317-n2knqj4z 432 17 can can MD cord-254317-n2knqj4z 432 18 also also RB cord-254317-n2knqj4z 432 19 cover cover VB cord-254317-n2knqj4z 432 20 viral viral JJ cord-254317-n2knqj4z 432 21 RBD rbd NN cord-254317-n2knqj4z 432 22 and and CC cord-254317-n2knqj4z 432 23 block block VB cord-254317-n2knqj4z 432 24 its -PRON- PRP$ cord-254317-n2knqj4z 432 25 binding binding NN cord-254317-n2knqj4z 432 26 to to IN cord-254317-n2knqj4z 432 27 the the DT cord-254317-n2knqj4z 432 28 receptors receptor NNS cord-254317-n2knqj4z 432 29 , , , cord-254317-n2knqj4z 432 30 resulting result VBG cord-254317-n2knqj4z 432 31 in in IN cord-254317-n2knqj4z 432 32 decreased decrease VBN cord-254317-n2knqj4z 432 33 infectivity infectivity NN cord-254317-n2knqj4z 432 34 as as IN cord-254317-n2knqj4z 432 35 observed observe VBN cord-254317-n2knqj4z 432 36 in in IN cord-254317-n2knqj4z 432 37 1.0 1.0 CD cord-254317-n2knqj4z 432 38 mg mg NNP cord-254317-n2knqj4z 432 39 / / SYM cord-254317-n2knqj4z 432 40 mL ml NN cord-254317-n2knqj4z 432 41 BM bm NN cord-254317-n2knqj4z 432 42 effects effect NNS cord-254317-n2knqj4z 432 43 on on IN cord-254317-n2knqj4z 432 44 S s NN cord-254317-n2knqj4z 432 45 - - HYPH cord-254317-n2knqj4z 432 46 intact intact JJ cord-254317-n2knqj4z 432 47 PEDV PEDV NNP cord-254317-n2knqj4z 432 48 in in IN cord-254317-n2knqj4z 432 49 Vero Vero NNP cord-254317-n2knqj4z 432 50 cells cell NNS cord-254317-n2knqj4z 432 51 ( ( -LRB- cord-254317-n2knqj4z 432 52 Fig Fig NNP cord-254317-n2knqj4z 432 53 . . . cord-254317-n2knqj4z 432 54 5A 5a CD cord-254317-n2knqj4z 432 55 ) ) -RRB- cord-254317-n2knqj4z 432 56 . . . cord-254317-n2knqj4z 433 1 The the DT cord-254317-n2knqj4z 433 2 major major JJ cord-254317-n2knqj4z 433 3 components component NNS cord-254317-n2knqj4z 433 4 of of IN cord-254317-n2knqj4z 433 5 bile bile NN cord-254317-n2knqj4z 433 6 include include VBP cord-254317-n2knqj4z 433 7 bile bile NN cord-254317-n2knqj4z 433 8 acids acid NNS cord-254317-n2knqj4z 433 9 , , , cord-254317-n2knqj4z 433 10 cholesterol cholesterol NN cord-254317-n2knqj4z 433 11 , , , cord-254317-n2knqj4z 433 12 lipids lipid NNS cord-254317-n2knqj4z 433 13 , , , cord-254317-n2knqj4z 433 14 bilirubin bilirubin NN cord-254317-n2knqj4z 433 15 , , , cord-254317-n2knqj4z 433 16 proteins protein NNS cord-254317-n2knqj4z 433 17 and and CC cord-254317-n2knqj4z 433 18 carbohydrates carbohydrate NNS cord-254317-n2knqj4z 433 19 . . . cord-254317-n2knqj4z 434 1 The the DT cord-254317-n2knqj4z 434 2 bile bile NN cord-254317-n2knqj4z 434 3 acids acid NNS cord-254317-n2knqj4z 434 4 are be VBP cord-254317-n2knqj4z 434 5 stored store VBN cord-254317-n2knqj4z 434 6 in in IN cord-254317-n2knqj4z 434 7 the the DT cord-254317-n2knqj4z 434 8 gall gall NN cord-254317-n2knqj4z 434 9 bladder bladder NN cord-254317-n2knqj4z 434 10 ( ( -LRB- cord-254317-n2knqj4z 434 11 at at IN cord-254317-n2knqj4z 434 12 ∼300 ∼300 NNP cord-254317-n2knqj4z 434 13 mM mM NNP cord-254317-n2knqj4z 434 14 ) ) -RRB- cord-254317-n2knqj4z 434 15 and and CC cord-254317-n2knqj4z 434 16 released release VBN cord-254317-n2knqj4z 434 17 into into IN cord-254317-n2knqj4z 434 18 the the DT cord-254317-n2knqj4z 434 19 small small JJ cord-254317-n2knqj4z 434 20 intestine intestine NN cord-254317-n2knqj4z 434 21 ( ( -LRB- cord-254317-n2knqj4z 434 22 McLeod McLeod NNP cord-254317-n2knqj4z 434 23 and and CC cord-254317-n2knqj4z 434 24 Wiggins Wiggins NNP cord-254317-n2knqj4z 434 25 , , , cord-254317-n2knqj4z 434 26 1968 1968 CD cord-254317-n2knqj4z 434 27 ) ) -RRB- cord-254317-n2knqj4z 434 28 . . . cord-254317-n2knqj4z 435 1 In in IN cord-254317-n2knqj4z 435 2 the the DT cord-254317-n2knqj4z 435 3 small small JJ cord-254317-n2knqj4z 435 4 intestine intestine NN cord-254317-n2knqj4z 435 5 , , , cord-254317-n2knqj4z 435 6 the the DT cord-254317-n2knqj4z 435 7 total total JJ cord-254317-n2knqj4z 435 8 bile bile NN cord-254317-n2knqj4z 435 9 acids acid NNS cord-254317-n2knqj4z 435 10 have have VBP cord-254317-n2knqj4z 435 11 a a DT cord-254317-n2knqj4z 435 12 concentration concentration NN cord-254317-n2knqj4z 435 13 of of IN cord-254317-n2knqj4z 435 14 2 2 CD cord-254317-n2knqj4z 435 15 - - SYM cord-254317-n2knqj4z 435 16 30 30 CD cord-254317-n2knqj4z 435 17 mM mm NN cord-254317-n2knqj4z 435 18 ( ( -LRB- cord-254317-n2knqj4z 435 19 Dowling Dowling NNP cord-254317-n2knqj4z 435 20 , , , cord-254317-n2knqj4z 435 21 1973 1973 CD cord-254317-n2knqj4z 435 22 ) ) -RRB- cord-254317-n2knqj4z 435 23 . . . cord-254317-n2knqj4z 436 1 We -PRON- PRP cord-254317-n2knqj4z 436 2 selected select VBD cord-254317-n2knqj4z 436 3 two two CD cord-254317-n2knqj4z 436 4 primary primary JJ cord-254317-n2knqj4z 436 5 bile bile NN cord-254317-n2knqj4z 436 6 acids acid NNS cord-254317-n2knqj4z 436 7 ( ( -LRB- cord-254317-n2knqj4z 436 8 GCDCA GCDCA NNP cord-254317-n2knqj4z 436 9 and and CC cord-254317-n2knqj4z 436 10 CDCA CDCA NNP cord-254317-n2knqj4z 436 11 ) ) -RRB- cord-254317-n2knqj4z 436 12 and and CC cord-254317-n2knqj4z 436 13 two two CD cord-254317-n2knqj4z 436 14 secondary secondary JJ cord-254317-n2knqj4z 436 15 bile bile NN cord-254317-n2knqj4z 436 16 acids acid NNS cord-254317-n2knqj4z 436 17 ( ( -LRB- cord-254317-n2knqj4z 436 18 DCA DCA NNP cord-254317-n2knqj4z 436 19 and and CC cord-254317-n2knqj4z 436 20 UDCA UDCA NNP cord-254317-n2knqj4z 436 21 ) ) -RRB- cord-254317-n2knqj4z 437 1 to to TO cord-254317-n2knqj4z 437 2 test test VB cord-254317-n2knqj4z 437 3 the the DT cord-254317-n2knqj4z 437 4 effects effect NNS cord-254317-n2knqj4z 437 5 of of IN cord-254317-n2knqj4z 437 6 bile bile NN cord-254317-n2knqj4z 437 7 acids acid NNS cord-254317-n2knqj4z 437 8 on on IN cord-254317-n2knqj4z 437 9 PEDV PEDV NNP cord-254317-n2knqj4z 437 10 infection infection NN cord-254317-n2knqj4z 437 11 . . . cord-254317-n2knqj4z 438 1 The the DT cord-254317-n2knqj4z 438 2 secondary secondary JJ cord-254317-n2knqj4z 438 3 bile bile NN cord-254317-n2knqj4z 438 4 acids acid NNS cord-254317-n2knqj4z 438 5 are be VBP cord-254317-n2knqj4z 438 6 dehydroxylated dehydroxylate VBN cord-254317-n2knqj4z 438 7 ones one NNS cord-254317-n2knqj4z 438 8 from from IN cord-254317-n2knqj4z 438 9 the the DT cord-254317-n2knqj4z 438 10 primary primary JJ cord-254317-n2knqj4z 438 11 bile bile NN cord-254317-n2knqj4z 438 12 acids acid NNS cord-254317-n2knqj4z 438 13 by by IN cord-254317-n2knqj4z 438 14 intestinal intestinal JJ cord-254317-n2knqj4z 438 15 bacteria bacteria NNS cord-254317-n2knqj4z 438 16 ( ( -LRB- cord-254317-n2knqj4z 438 17 Björkhem Björkhem NNP cord-254317-n2knqj4z 438 18 , , , cord-254317-n2knqj4z 438 19 1985 1985 CD cord-254317-n2knqj4z 438 20 ) ) -RRB- cord-254317-n2knqj4z 438 21 . . . cord-254317-n2knqj4z 439 1 Our -PRON- PRP$ cord-254317-n2knqj4z 439 2 data datum NNS cord-254317-n2knqj4z 439 3 indicated indicate VBD cord-254317-n2knqj4z 439 4 that that IN cord-254317-n2knqj4z 439 5 a a DT cord-254317-n2knqj4z 439 6 broad broad JJ cord-254317-n2knqj4z 439 7 range range NN cord-254317-n2knqj4z 439 8 of of IN cord-254317-n2knqj4z 439 9 concentrations concentration NNS cord-254317-n2knqj4z 439 10 of of IN cord-254317-n2knqj4z 439 11 bile bile NN cord-254317-n2knqj4z 439 12 and and CC cord-254317-n2knqj4z 439 13 bile bile NN cord-254317-n2knqj4z 439 14 acids acid NNS cord-254317-n2knqj4z 439 15 enhanced enhance VBD cord-254317-n2knqj4z 439 16 the the DT cord-254317-n2knqj4z 439 17 infectivity infectivity NN cord-254317-n2knqj4z 439 18 of of IN cord-254317-n2knqj4z 439 19 S s NN cord-254317-n2knqj4z 439 20 - - HYPH cord-254317-n2knqj4z 439 21 intact intact JJ cord-254317-n2knqj4z 439 22 PEDV PEDV NNP cord-254317-n2knqj4z 439 23 in in IN cord-254317-n2knqj4z 439 24 both both CC cord-254317-n2knqj4z 439 25 Vero Vero NNP cord-254317-n2knqj4z 439 26 and and CC cord-254317-n2knqj4z 439 27 IPEC IPEC NNP cord-254317-n2knqj4z 439 28 - - HYPH cord-254317-n2knqj4z 439 29 DQ dq NN cord-254317-n2knqj4z 439 30 cells cell NNS cord-254317-n2knqj4z 439 31 . . . cord-254317-n2knqj4z 440 1 However however RB cord-254317-n2knqj4z 440 2 , , , cord-254317-n2knqj4z 440 3 bile bile NN cord-254317-n2knqj4z 440 4 and and CC cord-254317-n2knqj4z 440 5 bile bile NN cord-254317-n2knqj4z 440 6 acids acid NNS cord-254317-n2knqj4z 440 7 can can MD cord-254317-n2knqj4z 440 8 not not RB cord-254317-n2knqj4z 440 9 increase increase VB cord-254317-n2knqj4z 440 10 the the DT cord-254317-n2knqj4z 440 11 infectivity infectivity NN cord-254317-n2knqj4z 440 12 of of IN cord-254317-n2knqj4z 440 13 S1 S1 NNP cord-254317-n2knqj4z 440 14 NTD NTD NNP cord-254317-n2knqj4z 440 15 - - HYPH cord-254317-n2knqj4z 440 16 del del NNP cord-254317-n2knqj4z 440 17 PEDV PEDV NNP cord-254317-n2knqj4z 440 18 . . . cord-254317-n2knqj4z 441 1 These these DT cord-254317-n2knqj4z 441 2 results result NNS cord-254317-n2knqj4z 441 3 suggest suggest VBP cord-254317-n2knqj4z 441 4 that that IN cord-254317-n2knqj4z 441 5 the the DT cord-254317-n2knqj4z 441 6 bile bile NN cord-254317-n2knqj4z 441 7 - - HYPH cord-254317-n2knqj4z 441 8 and and CC cord-254317-n2knqj4z 441 9 bile bile NN cord-254317-n2knqj4z 441 10 acid acid NN cord-254317-n2knqj4z 441 11 - - HYPH cord-254317-n2knqj4z 441 12 mediated mediate VBN cord-254317-n2knqj4z 441 13 promotion promotion NN cord-254317-n2knqj4z 441 14 of of IN cord-254317-n2knqj4z 441 15 PEDV PEDV NNP cord-254317-n2knqj4z 441 16 infection infection NN cord-254317-n2knqj4z 441 17 is be VBZ cord-254317-n2knqj4z 441 18 related relate VBN cord-254317-n2knqj4z 441 19 to to IN cord-254317-n2knqj4z 441 20 the the DT cord-254317-n2knqj4z 441 21 S1 S1 NNP cord-254317-n2knqj4z 441 22 NTD NTD NNP cord-254317-n2knqj4z 441 23 . . . cord-254317-n2knqj4z 442 1 It -PRON- PRP cord-254317-n2knqj4z 442 2 was be VBD cord-254317-n2knqj4z 442 3 reported report VBN cord-254317-n2knqj4z 442 4 that that IN cord-254317-n2knqj4z 442 5 GCDCA GCDCA NNP cord-254317-n2knqj4z 442 6 may may MD cord-254317-n2knqj4z 442 7 facilitate facilitate VB cord-254317-n2knqj4z 442 8 the the DT cord-254317-n2knqj4z 442 9 adaptation adaptation NN cord-254317-n2knqj4z 442 10 of of IN cord-254317-n2knqj4z 442 11 a a DT cord-254317-n2knqj4z 442 12 S s NN cord-254317-n2knqj4z 442 13 - - HYPH cord-254317-n2knqj4z 442 14 intact intact JJ cord-254317-n2knqj4z 442 15 PEDV PEDV NNP cord-254317-n2knqj4z 442 16 to to IN cord-254317-n2knqj4z 442 17 trypsin trypsin NN cord-254317-n2knqj4z 442 18 - - HYPH cord-254317-n2knqj4z 442 19 free free JJ cord-254317-n2knqj4z 442 20 growth growth NN cord-254317-n2knqj4z 442 21 in in IN cord-254317-n2knqj4z 442 22 Vero Vero NNP cord-254317-n2knqj4z 442 23 cells cell NNS cord-254317-n2knqj4z 442 24 at at IN cord-254317-n2knqj4z 442 25 the the DT cord-254317-n2knqj4z 442 26 early early JJ cord-254317-n2knqj4z 442 27 passages passage NNS cord-254317-n2knqj4z 442 28 ( ( -LRB- cord-254317-n2knqj4z 442 29 < < NNP cord-254317-n2knqj4z 442 30 P10 P10 NNP cord-254317-n2knqj4z 442 31 ) ) -RRB- cord-254317-n2knqj4z 442 32 ( ( -LRB- cord-254317-n2knqj4z 442 33 Kim Kim NNP cord-254317-n2knqj4z 442 34 et et NNP cord-254317-n2knqj4z 442 35 al al NNP cord-254317-n2knqj4z 442 36 . . NNP cord-254317-n2knqj4z 442 37 , , , cord-254317-n2knqj4z 442 38 2017 2017 CD cord-254317-n2knqj4z 442 39 ) ) -RRB- cord-254317-n2knqj4z 442 40 . . . cord-254317-n2knqj4z 443 1 However however RB cord-254317-n2knqj4z 443 2 , , , cord-254317-n2knqj4z 443 3 the the DT cord-254317-n2knqj4z 443 4 mechanisms mechanism NNS cord-254317-n2knqj4z 443 5 of of IN cord-254317-n2knqj4z 443 6 the the DT cord-254317-n2knqj4z 443 7 bile bile NN cord-254317-n2knqj4z 443 8 acid acid NN cord-254317-n2knqj4z 443 9 function function NN cord-254317-n2knqj4z 443 10 on on IN cord-254317-n2knqj4z 443 11 the the DT cord-254317-n2knqj4z 443 12 PEDV PEDV NNP cord-254317-n2knqj4z 443 13 infection infection NN cord-254317-n2knqj4z 443 14 is be VBZ cord-254317-n2knqj4z 443 15 unknown unknown JJ cord-254317-n2knqj4z 443 16 and and CC cord-254317-n2knqj4z 443 17 consequently consequently RB cord-254317-n2knqj4z 443 18 need need VBP cord-254317-n2knqj4z 443 19 to to TO cord-254317-n2knqj4z 443 20 be be VB cord-254317-n2knqj4z 443 21 further further RB cord-254317-n2knqj4z 443 22 investigated investigate VBN cord-254317-n2knqj4z 443 23 . . . cord-254317-n2knqj4z 444 1 The the DT cord-254317-n2knqj4z 444 2 inability inability NN cord-254317-n2knqj4z 444 3 of of IN cord-254317-n2knqj4z 444 4 the the DT cord-254317-n2knqj4z 444 5 S1 S1 NNP cord-254317-n2knqj4z 444 6 NTD NTD NNP cord-254317-n2knqj4z 444 7 - - HYPH cord-254317-n2knqj4z 444 8 del del NNP cord-254317-n2knqj4z 444 9 PEDV PEDV NNP cord-254317-n2knqj4z 444 10 to to TO cord-254317-n2knqj4z 444 11 outcompete outcompete VB cord-254317-n2knqj4z 444 12 the the DT cord-254317-n2knqj4z 444 13 S s NN cord-254317-n2knqj4z 444 14 - - HYPH cord-254317-n2knqj4z 444 15 intact intact JJ cord-254317-n2knqj4z 444 16 PEDV PEDV NNP cord-254317-n2knqj4z 444 17 may may MD cord-254317-n2knqj4z 444 18 account account VB cord-254317-n2knqj4z 444 19 for for IN cord-254317-n2knqj4z 444 20 the the DT cord-254317-n2knqj4z 444 21 fact fact NN cord-254317-n2knqj4z 444 22 that that IN cord-254317-n2knqj4z 444 23 S1 S1 NNP cord-254317-n2knqj4z 444 24 NTD NTD NNP cord-254317-n2knqj4z 444 25 - - HYPH cord-254317-n2knqj4z 444 26 del del NNP cord-254317-n2knqj4z 444 27 PEDVs pedv NNS cord-254317-n2knqj4z 444 28 were be VBD cord-254317-n2knqj4z 444 29 exclusively exclusively RB cord-254317-n2knqj4z 444 30 detected detect VBN cord-254317-n2knqj4z 444 31 from from IN cord-254317-n2knqj4z 444 32 coinfection coinfection NN cord-254317-n2knqj4z 444 33 with with IN cord-254317-n2knqj4z 444 34 the the DT cord-254317-n2knqj4z 444 35 S s NN cord-254317-n2knqj4z 444 36 - - HYPH cord-254317-n2knqj4z 444 37 intact intact JJ cord-254317-n2knqj4z 444 38 PEDV PEDV NNP cord-254317-n2knqj4z 445 1 ( ( -LRB- cord-254317-n2knqj4z 445 2 Diep Diep NNP cord-254317-n2knqj4z 445 3 et et FW cord-254317-n2knqj4z 445 4 al al NNP cord-254317-n2knqj4z 445 5 . . NNP cord-254317-n2knqj4z 445 6 , , , cord-254317-n2knqj4z 445 7 2017 2017 CD cord-254317-n2knqj4z 445 8 ; ; : cord-254317-n2knqj4z 445 9 Su Su NNP cord-254317-n2knqj4z 445 10 et et FW cord-254317-n2knqj4z 445 11 al al NNP cord-254317-n2knqj4z 445 12 . . NNP cord-254317-n2knqj4z 445 13 , , , cord-254317-n2knqj4z 445 14 2018 2018 CD cord-254317-n2knqj4z 445 15 ) ) -RRB- cord-254317-n2knqj4z 445 16 . . . cord-254317-n2knqj4z 446 1 Consequently consequently RB cord-254317-n2knqj4z 446 2 , , , cord-254317-n2knqj4z 446 3 the the DT cord-254317-n2knqj4z 446 4 disease disease NN cord-254317-n2knqj4z 446 5 caused cause VBN cord-254317-n2knqj4z 446 6 by by IN cord-254317-n2knqj4z 446 7 the the DT cord-254317-n2knqj4z 446 8 coinfection coinfection NN cord-254317-n2knqj4z 446 9 was be VBD cord-254317-n2knqj4z 446 10 as as RB cord-254317-n2knqj4z 446 11 severe severe JJ cord-254317-n2knqj4z 446 12 as as IN cord-254317-n2knqj4z 446 13 that that DT cord-254317-n2knqj4z 446 14 by by IN cord-254317-n2knqj4z 446 15 the the DT cord-254317-n2knqj4z 446 16 highly highly RB cord-254317-n2knqj4z 446 17 virulent virulent JJ cord-254317-n2knqj4z 446 18 S s NN cord-254317-n2knqj4z 446 19 - - HYPH cord-254317-n2knqj4z 446 20 intact intact JJ cord-254317-n2knqj4z 446 21 PEDV PEDV NNP cord-254317-n2knqj4z 446 22 alone alone RB cord-254317-n2knqj4z 446 23 . . . cord-254317-n2knqj4z 447 1 This this DT cord-254317-n2knqj4z 447 2 situation situation NN cord-254317-n2knqj4z 447 3 is be VBZ cord-254317-n2knqj4z 447 4 quite quite RB cord-254317-n2knqj4z 447 5 different different JJ cord-254317-n2knqj4z 447 6 from from IN cord-254317-n2knqj4z 447 7 what what WP cord-254317-n2knqj4z 447 8 occurred occur VBD cord-254317-n2knqj4z 447 9 for for IN cord-254317-n2knqj4z 447 10 PRCV PRCV NNP cord-254317-n2knqj4z 447 11 and and CC cord-254317-n2knqj4z 447 12 TGEV TGEV NNP cord-254317-n2knqj4z 447 13 : : : cord-254317-n2knqj4z 447 14 the the DT cord-254317-n2knqj4z 447 15 wild wild JJ cord-254317-n2knqj4z 447 16 spread spread NN cord-254317-n2knqj4z 447 17 of of IN cord-254317-n2knqj4z 447 18 clinically clinically RB cord-254317-n2knqj4z 447 19 mild mild JJ cord-254317-n2knqj4z 447 20 PRCV PRCV NNS cord-254317-n2knqj4z 447 21 , , , cord-254317-n2knqj4z 447 22 which which WDT cord-254317-n2knqj4z 447 23 often often RB cord-254317-n2knqj4z 447 24 infects infect VBZ cord-254317-n2knqj4z 447 25 pigs pig NNS cord-254317-n2knqj4z 447 26 asymptomatically asymptomatically RB cord-254317-n2knqj4z 447 27 and and CC cord-254317-n2knqj4z 447 28 repeatedly repeatedly RB cord-254317-n2knqj4z 447 29 , , , cord-254317-n2knqj4z 447 30 inducing induce VBG cord-254317-n2knqj4z 447 31 protective protective JJ cord-254317-n2knqj4z 447 32 herd herd NN cord-254317-n2knqj4z 447 33 immunity immunity NN cord-254317-n2knqj4z 447 34 against against IN cord-254317-n2knqj4z 447 35 TGEV TGEV NNP cord-254317-n2knqj4z 447 36 outbreaks outbreak NNS cord-254317-n2knqj4z 448 1 ( ( -LRB- cord-254317-n2knqj4z 448 2 VanCott VanCott NNP cord-254317-n2knqj4z 448 3 et et FW cord-254317-n2knqj4z 448 4 al al NNP cord-254317-n2knqj4z 448 5 . . . cord-254317-n2knqj4z 449 1 , , , cord-254317-n2knqj4z 449 2 1994 1994 CD cord-254317-n2knqj4z 449 3 ; ; : cord-254317-n2knqj4z 449 4 Brim Brim NNP cord-254317-n2knqj4z 449 5 et et FW cord-254317-n2knqj4z 449 6 al al NNP cord-254317-n2knqj4z 449 7 . . NNP cord-254317-n2knqj4z 449 8 , , , cord-254317-n2knqj4z 449 9 1995 1995 CD cord-254317-n2knqj4z 449 10 ) ) -RRB- cord-254317-n2knqj4z 449 11 . . . cord-254317-n2knqj4z 450 1 PRCV PRCV NNP cord-254317-n2knqj4z 450 2 functions function NNS cord-254317-n2knqj4z 450 3 as as IN cord-254317-n2knqj4z 450 4 a a DT cord-254317-n2knqj4z 450 5 natural natural JJ cord-254317-n2knqj4z 450 6 effective effective JJ cord-254317-n2knqj4z 450 7 vaccine vaccine NN cord-254317-n2knqj4z 450 8 against against IN cord-254317-n2knqj4z 450 9 TGEV TGEV NNP cord-254317-n2knqj4z 450 10 . . . cord-254317-n2knqj4z 451 1 However however RB cord-254317-n2knqj4z 451 2 , , , cord-254317-n2knqj4z 451 3 for for IN cord-254317-n2knqj4z 451 4 PEDV PEDV NNP cord-254317-n2knqj4z 451 5 , , , cord-254317-n2knqj4z 451 6 the the DT cord-254317-n2knqj4z 451 7 clinically clinically RB cord-254317-n2knqj4z 451 8 mild mild JJ cord-254317-n2knqj4z 451 9 S1 S1 NNP cord-254317-n2knqj4z 451 10 NTD NTD NNP cord-254317-n2knqj4z 451 11 - - HYPH cord-254317-n2knqj4z 451 12 del del NNP cord-254317-n2knqj4z 451 13 PEDV PEDV NNP cord-254317-n2knqj4z 451 14 variants variant NNS cord-254317-n2knqj4z 451 15 do do VBP cord-254317-n2knqj4z 451 16 not not RB cord-254317-n2knqj4z 451 17 infect infect VB cord-254317-n2knqj4z 451 18 pigs pig NNS cord-254317-n2knqj4z 451 19 alone alone JJ cord-254317-n2knqj4z 451 20 . . . cord-254317-n2knqj4z 452 1 Therefore therefore RB cord-254317-n2knqj4z 452 2 , , , cord-254317-n2knqj4z 452 3 safe safe JJ cord-254317-n2knqj4z 452 4 and and CC cord-254317-n2knqj4z 452 5 effective effective JJ cord-254317-n2knqj4z 452 6 vaccines vaccine NNS cord-254317-n2knqj4z 452 7 are be VBP cord-254317-n2knqj4z 452 8 still still RB cord-254317-n2knqj4z 452 9 desired desire VBN cord-254317-n2knqj4z 452 10 to to TO cord-254317-n2knqj4z 452 11 control control VB cord-254317-n2knqj4z 452 12 the the DT cord-254317-n2knqj4z 452 13 deadly deadly JJ cord-254317-n2knqj4z 452 14 PEDV PEDV NNP cord-254317-n2knqj4z 452 15 infection infection NN cord-254317-n2knqj4z 452 16 in in IN cord-254317-n2knqj4z 452 17 neonatal neonatal JJ cord-254317-n2knqj4z 452 18 piglets piglet NNS cord-254317-n2knqj4z 452 19 . . . cord-254317-n2knqj4z 453 1 Due due IN cord-254317-n2knqj4z 453 2 to to IN cord-254317-n2knqj4z 453 3 the the DT cord-254317-n2knqj4z 453 4 100 100 CD cord-254317-n2knqj4z 453 5 % % NN cord-254317-n2knqj4z 453 6 mortality mortality NN cord-254317-n2knqj4z 453 7 rates rate NNS cord-254317-n2knqj4z 453 8 of of IN cord-254317-n2knqj4z 453 9 piglets piglet NNS cord-254317-n2knqj4z 453 10 in in IN cord-254317-n2knqj4z 453 11 the the DT cord-254317-n2knqj4z 453 12 icPC22 icPC22 NNP cord-254317-n2knqj4z 453 13 A a RB cord-254317-n2knqj4z 453 14 - - HYPH cord-254317-n2knqj4z 453 15 infected infect VBN cord-254317-n2knqj4z 453 16 pigs pig NNS cord-254317-n2knqj4z 454 1 ( ( -LRB- cord-254317-n2knqj4z 454 2 Hou Hou NNP cord-254317-n2knqj4z 454 3 et et NNP cord-254317-n2knqj4z 454 4 al al NNP cord-254317-n2knqj4z 454 5 . . NNP cord-254317-n2knqj4z 454 6 , , , cord-254317-n2knqj4z 454 7 2017 2017 CD cord-254317-n2knqj4z 454 8 ) ) -RRB- cord-254317-n2knqj4z 454 9 and and CC cord-254317-n2knqj4z 455 1 coinfection coinfection NN cord-254317-n2knqj4z 455 2 groups group NNS cord-254317-n2knqj4z 455 3 , , , cord-254317-n2knqj4z 455 4 we -PRON- PRP cord-254317-n2knqj4z 455 5 currently currently RB cord-254317-n2knqj4z 455 6 can can MD cord-254317-n2knqj4z 455 7 not not RB cord-254317-n2knqj4z 455 8 determine determine VB cord-254317-n2knqj4z 455 9 whether whether IN cord-254317-n2knqj4z 455 10 the the DT cord-254317-n2knqj4z 455 11 pathogenicity pathogenicity NN cord-254317-n2knqj4z 455 12 of of IN cord-254317-n2knqj4z 455 13 PEDV PEDV NNP cord-254317-n2knqj4z 455 14 icPC22 icPC22 NNP cord-254317-n2knqj4z 455 15 A A NNP cord-254317-n2knqj4z 455 16 is be VBZ cord-254317-n2knqj4z 455 17 enhanced enhance VBN cord-254317-n2knqj4z 455 18 during during IN cord-254317-n2knqj4z 455 19 the the DT cord-254317-n2knqj4z 455 20 coinfection coinfection NN cord-254317-n2knqj4z 455 21 . . . cord-254317-n2knqj4z 456 1 That that DT cord-254317-n2knqj4z 456 2 should should MD cord-254317-n2knqj4z 456 3 be be VB cord-254317-n2knqj4z 456 4 investigated investigate VBN cord-254317-n2knqj4z 456 5 in in IN cord-254317-n2knqj4z 456 6 older old JJR cord-254317-n2knqj4z 456 7 pigs pig NNS cord-254317-n2knqj4z 456 8 ( ( -LRB- cord-254317-n2knqj4z 456 9 weaned wean VBN cord-254317-n2knqj4z 456 10 pigs pig NNS cord-254317-n2knqj4z 456 11 , , , cord-254317-n2knqj4z 456 12 sows sow NNS cord-254317-n2knqj4z 456 13 and and CC cord-254317-n2knqj4z 456 14 boars boar NNS cord-254317-n2knqj4z 456 15 ) ) -RRB- cord-254317-n2knqj4z 456 16 which which WDT cord-254317-n2knqj4z 456 17 are be VBP cord-254317-n2knqj4z 456 18 more more RBR cord-254317-n2knqj4z 456 19 resistant resistant JJ cord-254317-n2knqj4z 456 20 to to IN cord-254317-n2knqj4z 456 21 PEDV PEDV NNP cord-254317-n2knqj4z 456 22 infection infection NN cord-254317-n2knqj4z 456 23 and and CC cord-254317-n2knqj4z 456 24 diseases disease NNS cord-254317-n2knqj4z 456 25 ( ( -LRB- cord-254317-n2knqj4z 456 26 Niederwerder Niederwerder NNP cord-254317-n2knqj4z 456 27 and and CC cord-254317-n2knqj4z 456 28 Hesse Hesse NNP cord-254317-n2knqj4z 456 29 , , , cord-254317-n2knqj4z 456 30 2018 2018 CD cord-254317-n2knqj4z 456 31 ) ) -RRB- cord-254317-n2knqj4z 456 32 . . . cord-254317-n2knqj4z 457 1 In in IN cord-254317-n2knqj4z 457 2 addition addition NN cord-254317-n2knqj4z 457 3 , , , cord-254317-n2knqj4z 457 4 the the DT cord-254317-n2knqj4z 457 5 emergence emergence NN cord-254317-n2knqj4z 457 6 of of IN cord-254317-n2knqj4z 457 7 S1 S1 NNP cord-254317-n2knqj4z 457 8 NTD NTD NNP cord-254317-n2knqj4z 457 9 - - HYPH cord-254317-n2knqj4z 457 10 del del NNP cord-254317-n2knqj4z 457 11 PEDV PEDV NNP cord-254317-n2knqj4z 457 12 variants variant NNS cord-254317-n2knqj4z 457 13 may may MD cord-254317-n2knqj4z 457 14 complicate complicate VB cord-254317-n2knqj4z 457 15 PEDV PEDV NNP cord-254317-n2knqj4z 457 16 disease disease NN cord-254317-n2knqj4z 457 17 pattern pattern NN cord-254317-n2knqj4z 457 18 on on IN cord-254317-n2knqj4z 457 19 farms farm NNS cord-254317-n2knqj4z 457 20 , , , cord-254317-n2knqj4z 457 21 which which WDT cord-254317-n2knqj4z 457 22 needs need VBZ cord-254317-n2knqj4z 457 23 to to TO cord-254317-n2knqj4z 457 24 be be VB cord-254317-n2knqj4z 457 25 further further RB cord-254317-n2knqj4z 457 26 investigated investigate VBN cord-254317-n2knqj4z 457 27 . . . cord-254317-n2knqj4z 458 1 In in IN cord-254317-n2knqj4z 458 2 this this DT cord-254317-n2knqj4z 458 3 study study NN cord-254317-n2knqj4z 458 4 , , , cord-254317-n2knqj4z 458 5 we -PRON- PRP cord-254317-n2knqj4z 458 6 showed show VBD cord-254317-n2knqj4z 458 7 that that IN cord-254317-n2knqj4z 458 8 the the DT cord-254317-n2knqj4z 458 9 replication replication NN cord-254317-n2knqj4z 458 10 of of IN cord-254317-n2knqj4z 458 11 the the DT cord-254317-n2knqj4z 458 12 S s NN cord-254317-n2knqj4z 458 13 - - HYPH cord-254317-n2knqj4z 458 14 intact intact JJ cord-254317-n2knqj4z 458 15 PEDV PEDV NNP cord-254317-n2knqj4z 458 16 was be VBD cord-254317-n2knqj4z 458 17 enhanced enhance VBN cord-254317-n2knqj4z 458 18 during during IN cord-254317-n2knqj4z 458 19 coinfection coinfection NN cord-254317-n2knqj4z 458 20 with with IN cord-254317-n2knqj4z 458 21 an an DT cord-254317-n2knqj4z 458 22 S1 S1 NNP cord-254317-n2knqj4z 458 23 NTD NTD NNP cord-254317-n2knqj4z 458 24 - - HYPH cord-254317-n2knqj4z 458 25 del del NNP cord-254317-n2knqj4z 458 26 PEDV PEDV NNP cord-254317-n2knqj4z 458 27 in in IN cord-254317-n2knqj4z 458 28 pigs pig NNS cord-254317-n2knqj4z 458 29 . . . cord-254317-n2knqj4z 459 1 We -PRON- PRP cord-254317-n2knqj4z 459 2 found find VBD cord-254317-n2knqj4z 459 3 that that DT cord-254317-n2knqj4z 459 4 mucin mucin NN cord-254317-n2knqj4z 459 5 , , , cord-254317-n2knqj4z 459 6 bile bile NN cord-254317-n2knqj4z 459 7 and and CC cord-254317-n2knqj4z 459 8 bile bile NN cord-254317-n2knqj4z 459 9 acids acid NNS cord-254317-n2knqj4z 459 10 can can MD cord-254317-n2knqj4z 459 11 all all DT cord-254317-n2knqj4z 459 12 increase increase VB cord-254317-n2knqj4z 459 13 the the DT cord-254317-n2knqj4z 459 14 infection infection NN cord-254317-n2knqj4z 459 15 of of IN cord-254317-n2knqj4z 459 16 Sintact Sintact NNP cord-254317-n2knqj4z 459 17 PEDV PEDV NNP cord-254317-n2knqj4z 459 18 but but CC cord-254317-n2knqj4z 459 19 not not RB cord-254317-n2knqj4z 459 20 the the DT cord-254317-n2knqj4z 459 21 S1 S1 NNP cord-254317-n2knqj4z 459 22 NTD NTD NNP cord-254317-n2knqj4z 459 23 - - HYPH cord-254317-n2knqj4z 459 24 del del NNP cord-254317-n2knqj4z 459 25 PEDV PEDV NNP cord-254317-n2knqj4z 459 26 . . . cord-254317-n2knqj4z 460 1 This this DT cord-254317-n2knqj4z 460 2 feature feature NN cord-254317-n2knqj4z 460 3 may may MD cord-254317-n2knqj4z 460 4 help help VB cord-254317-n2knqj4z 460 5 explain explain VB cord-254317-n2knqj4z 460 6 why why WRB cord-254317-n2knqj4z 460 7 S s NN cord-254317-n2knqj4z 460 8 - - HYPH cord-254317-n2knqj4z 460 9 intact intact JJ cord-254317-n2knqj4z 460 10 PEDV PEDV NNP cord-254317-n2knqj4z 460 11 outcompetes outcompete VBZ cord-254317-n2knqj4z 460 12 S1 S1 NNP cord-254317-n2knqj4z 460 13 NTD NTD NNP cord-254317-n2knqj4z 460 14 - - HYPH cord-254317-n2knqj4z 460 15 del del NNP cord-254317-n2knqj4z 460 16 PEDV PEDV NNP cord-254317-n2knqj4z 460 17 in in IN cord-254317-n2knqj4z 460 18 vivo vivo NN cord-254317-n2knqj4z 460 19 . . . cord-254317-n2knqj4z 461 1 Further further JJ cord-254317-n2knqj4z 461 2 studies study NNS cord-254317-n2knqj4z 461 3 are be VBP cord-254317-n2knqj4z 461 4 needed need VBN cord-254317-n2knqj4z 461 5 to to TO cord-254317-n2knqj4z 461 6 understand understand VB cord-254317-n2knqj4z 461 7 the the DT cord-254317-n2knqj4z 461 8 mechanisms mechanism NNS cord-254317-n2knqj4z 461 9 of of IN cord-254317-n2knqj4z 461 10 mucin- mucin- NN cord-254317-n2knqj4z 461 11 , , , cord-254317-n2knqj4z 461 12 bile bile NN cord-254317-n2knqj4z 461 13 - - HYPH cord-254317-n2knqj4z 461 14 and and CC cord-254317-n2knqj4z 461 15 bile bile NN cord-254317-n2knqj4z 461 16 acid acid NN cord-254317-n2knqj4z 461 17 - - HYPH cord-254317-n2knqj4z 461 18 mediated mediate VBN cord-254317-n2knqj4z 461 19 enhancement enhancement NN cord-254317-n2knqj4z 461 20 or or CC cord-254317-n2knqj4z 461 21 inhibition inhibition NN cord-254317-n2knqj4z 461 22 effects effect NNS cord-254317-n2knqj4z 461 23 on on IN cord-254317-n2knqj4z 461 24 the the DT cord-254317-n2knqj4z 461 25 infection infection NN cord-254317-n2knqj4z 461 26 of of IN cord-254317-n2knqj4z 461 27 different different JJ cord-254317-n2knqj4z 461 28 PEDV PEDV NNP cord-254317-n2knqj4z 461 29 variants variant NNS cord-254317-n2knqj4z 461 30 . . . cord-254317-n2knqj4z 462 1 All all DT cord-254317-n2knqj4z 462 2 animal animal NN cord-254317-n2knqj4z 462 3 experiments experiment NNS cord-254317-n2knqj4z 462 4 were be VBD cord-254317-n2knqj4z 462 5 performed perform VBN cord-254317-n2knqj4z 462 6 according accord VBG cord-254317-n2knqj4z 462 7 to to IN cord-254317-n2knqj4z 462 8 the the DT cord-254317-n2knqj4z 462 9 protocols protocol NNS cord-254317-n2knqj4z 462 10 approved approve VBN cord-254317-n2knqj4z 462 11 by by IN cord-254317-n2knqj4z 462 12 Institutional Institutional NNP cord-254317-n2knqj4z 462 13 Animal Animal NNP cord-254317-n2knqj4z 462 14 Care Care NNP cord-254317-n2knqj4z 462 15 and and CC cord-254317-n2knqj4z 462 16 Use Use NNP cord-254317-n2knqj4z 462 17 Committee Committee NNP cord-254317-n2knqj4z 462 18 ( ( -LRB- cord-254317-n2knqj4z 462 19 IACUC IACUC NNP cord-254317-n2knqj4z 462 20 ) ) -RRB- cord-254317-n2knqj4z 462 21 of of IN cord-254317-n2knqj4z 462 22 the the DT cord-254317-n2knqj4z 462 23 Ohio Ohio NNP cord-254317-n2knqj4z 462 24 State State NNP cord-254317-n2knqj4z 462 25 University University NNP cord-254317-n2knqj4z 462 26 ( ( -LRB- cord-254317-n2knqj4z 462 27 OSU OSU NNP cord-254317-n2knqj4z 462 28 ) ) -RRB- cord-254317-n2knqj4z 462 29 . . . cord-254317-n2knqj4z 463 1 Mechanism mechanism NN cord-254317-n2knqj4z 463 2 of of IN cord-254317-n2knqj4z 463 3 bile bile NN cord-254317-n2knqj4z 463 4 acid acid NN cord-254317-n2knqj4z 463 5 biosynthesis biosynthesis NN cord-254317-n2knqj4z 463 6 in in IN cord-254317-n2knqj4z 463 7 mammalian mammalian JJ cord-254317-n2knqj4z 463 8 liver liver NN cord-254317-n2knqj4z 463 9 Cellular cellular JJ cord-254317-n2knqj4z 463 10 immune immune JJ cord-254317-n2knqj4z 463 11 responses response NNS cord-254317-n2knqj4z 463 12 of of IN cord-254317-n2knqj4z 463 13 pigs pig NNS cord-254317-n2knqj4z 463 14 after after IN cord-254317-n2knqj4z 463 15 primary primary JJ cord-254317-n2knqj4z 463 16 inoculation inoculation NN cord-254317-n2knqj4z 463 17 with with IN cord-254317-n2knqj4z 463 18 porcine porcine JJ cord-254317-n2knqj4z 463 19 respiratory respiratory JJ cord-254317-n2knqj4z 463 20 coronavirus coronavirus NN cord-254317-n2knqj4z 463 21 or or CC cord-254317-n2knqj4z 463 22 transmissible transmissible JJ cord-254317-n2knqj4z 463 23 gastroenteritis gastroenteritis NN cord-254317-n2knqj4z 463 24 virus virus NN cord-254317-n2knqj4z 463 25 and and CC cord-254317-n2knqj4z 463 26 challenge challenge NN cord-254317-n2knqj4z 463 27 with with IN cord-254317-n2knqj4z 463 28 transmissible transmissible JJ cord-254317-n2knqj4z 463 29 gastroenteritis gastroenteritis NN cord-254317-n2knqj4z 463 30 virus virus NN cord-254317-n2knqj4z 463 31 Coronavirus Coronavirus NNP cord-254317-n2knqj4z 463 32 IBV IBV NNP cord-254317-n2knqj4z 463 33 : : : cord-254317-n2knqj4z 464 1 removal removal NN cord-254317-n2knqj4z 464 2 of of IN cord-254317-n2knqj4z 464 3 spike spike NN cord-254317-n2knqj4z 464 4 glycopolypeptide glycopolypeptide NN cord-254317-n2knqj4z 464 5 S1 s1 NN cord-254317-n2knqj4z 464 6 by by IN cord-254317-n2knqj4z 464 7 urea urea NN cord-254317-n2knqj4z 464 8 abolishes abolish VBZ cord-254317-n2knqj4z 464 9 infectivity infectivity NN cord-254317-n2knqj4z 464 10 and and CC cord-254317-n2knqj4z 464 11 haemagglutination haemagglutination NN cord-254317-n2knqj4z 464 12 but but CC cord-254317-n2knqj4z 464 13 not not RB cord-254317-n2knqj4z 464 14 attachment attachment NN cord-254317-n2knqj4z 464 15 to to TO cord-254317-n2knqj4z 464 16 cells cells VB cord-254317-n2knqj4z 464 17 Bile bile NN cord-254317-n2knqj4z 464 18 acids acid NNS cord-254317-n2knqj4z 464 19 are be VBP cord-254317-n2knqj4z 464 20 essential essential JJ cord-254317-n2knqj4z 464 21 for for IN cord-254317-n2knqj4z 464 22 porcine porcine JJ cord-254317-n2knqj4z 464 23 enteric enteric JJ cord-254317-n2knqj4z 464 24 calicivirus calicivirus NN cord-254317-n2knqj4z 464 25 replication replication NN cord-254317-n2knqj4z 464 26 in in IN cord-254317-n2knqj4z 464 27 association association NN cord-254317-n2knqj4z 464 28 with with IN cord-254317-n2knqj4z 464 29 downregulation downregulation NN cord-254317-n2knqj4z 464 30 of of IN cord-254317-n2knqj4z 464 31 signal signal NN cord-254317-n2knqj4z 464 32 transducer transducer NN cord-254317-n2knqj4z 464 33 and and CC cord-254317-n2knqj4z 464 34 activator activator NN cord-254317-n2knqj4z 464 35 of of IN cord-254317-n2knqj4z 464 36 transcription transcription NN cord-254317-n2knqj4z 464 37 1 1 CD cord-254317-n2knqj4z 464 38 Identification identification NN cord-254317-n2knqj4z 464 39 and and CC cord-254317-n2knqj4z 464 40 comparison comparison NN cord-254317-n2knqj4z 464 41 of of IN cord-254317-n2knqj4z 464 42 receptor receptor NN cord-254317-n2knqj4z 464 43 binding bind VBG cord-254317-n2knqj4z 464 44 characteristics characteristic NNS cord-254317-n2knqj4z 464 45 of of IN cord-254317-n2knqj4z 464 46 the the DT cord-254317-n2knqj4z 464 47 spike spike NN cord-254317-n2knqj4z 464 48 protein protein NN cord-254317-n2knqj4z 464 49 of of IN cord-254317-n2knqj4z 464 50 two two CD cord-254317-n2knqj4z 464 51 porcine porcine JJ cord-254317-n2knqj4z 464 52 epidemic epidemic NN cord-254317-n2knqj4z 464 53 diarrhea diarrhea NN cord-254317-n2knqj4z 464 54 virus virus NN cord-254317-n2knqj4z 464 55 strains strain VBZ cord-254317-n2knqj4z 464 56 Role role NN cord-254317-n2knqj4z 464 57 of of IN cord-254317-n2knqj4z 464 58 sialic sialic JJ cord-254317-n2knqj4z 464 59 acids acid NNS cord-254317-n2knqj4z 464 60 in in IN cord-254317-n2knqj4z 464 61 feline feline JJ cord-254317-n2knqj4z 464 62 enteric enteric JJ cord-254317-n2knqj4z 464 63 coronavirus coronavirus NN cord-254317-n2knqj4z 464 64 infections infection NNS cord-254317-n2knqj4z 464 65 Novel Novel NNP cord-254317-n2knqj4z 464 66 porcine porcine JJ cord-254317-n2knqj4z 464 67 epidemic epidemic NN cord-254317-n2knqj4z 464 68 diarrhea diarrhea NN cord-254317-n2knqj4z 464 69 virus virus NN cord-254317-n2knqj4z 464 70 ( ( -LRB- cord-254317-n2knqj4z 464 71 PEDV PEDV NNP cord-254317-n2knqj4z 464 72 ) ) -RRB- cord-254317-n2knqj4z 464 73 variants variant NNS cord-254317-n2knqj4z 464 74 with with IN cord-254317-n2knqj4z 464 75 large large JJ cord-254317-n2knqj4z 464 76 deletions deletion NNS cord-254317-n2knqj4z 464 77 in in IN cord-254317-n2knqj4z 464 78 the the DT cord-254317-n2knqj4z 464 79 spike spike NN cord-254317-n2knqj4z 464 80 ( ( -LRB- cord-254317-n2knqj4z 464 81 S s NN cord-254317-n2knqj4z 464 82 ) ) -RRB- cord-254317-n2knqj4z 464 83 gene gene NN cord-254317-n2knqj4z 464 84 coexist coexist VBP cord-254317-n2knqj4z 464 85 with with IN cord-254317-n2knqj4z 464 86 PEDV PEDV NNP cord-254317-n2knqj4z 464 87 strains strain NNS cord-254317-n2knqj4z 464 88 possessing possess VBG cord-254317-n2knqj4z 464 89 an an DT cord-254317-n2knqj4z 464 90 intact intact JJ cord-254317-n2knqj4z 464 91 S s NN cord-254317-n2knqj4z 464 92 gene gene NN cord-254317-n2knqj4z 464 93 in in IN cord-254317-n2knqj4z 464 94 domestic domestic JJ cord-254317-n2knqj4z 464 95 pigs pig NNS cord-254317-n2knqj4z 464 96 in in IN cord-254317-n2knqj4z 464 97 Japan Japan NNP cord-254317-n2knqj4z 464 98 : : : cord-254317-n2knqj4z 464 99 a a DT cord-254317-n2knqj4z 464 100 new new JJ cord-254317-n2knqj4z 464 101 disease disease NN cord-254317-n2knqj4z 464 102 situation situation NN cord-254317-n2knqj4z 465 1 The the DT cord-254317-n2knqj4z 465 2 enterohepatic enterohepatic JJ cord-254317-n2knqj4z 465 3 circulation circulation NN cord-254317-n2knqj4z 465 4 of of IN cord-254317-n2knqj4z 465 5 bile bile NN cord-254317-n2knqj4z 465 6 acids acid NNS cord-254317-n2knqj4z 465 7 as as IN cord-254317-n2knqj4z 465 8 they -PRON- PRP cord-254317-n2knqj4z 465 9 relate relate VBP cord-254317-n2knqj4z 465 10 to to IN cord-254317-n2knqj4z 465 11 lipid lipid NN cord-254317-n2knqj4z 465 12 disorders disorder NNS cord-254317-n2knqj4z 465 13 Replication replication NN cord-254317-n2knqj4z 465 14 of of IN cord-254317-n2knqj4z 465 15 human human JJ cord-254317-n2knqj4z 465 16 noroviruses noroviruse NNS cord-254317-n2knqj4z 465 17 in in IN cord-254317-n2knqj4z 465 18 stem stem NN cord-254317-n2knqj4z 465 19 cell cell NN cord-254317-n2knqj4z 465 20 - - HYPH cord-254317-n2knqj4z 465 21 derived derive VBN cord-254317-n2knqj4z 465 22 human human JJ cord-254317-n2knqj4z 465 23 enteroids enteroid NNS cord-254317-n2knqj4z 465 24 Deletion deletion NN cord-254317-n2knqj4z 465 25 of of IN cord-254317-n2knqj4z 465 26 a a DT cord-254317-n2knqj4z 465 27 197-Amino 197-amino CD cord-254317-n2knqj4z 465 28 - - HYPH cord-254317-n2knqj4z 465 29 Acid acid NN cord-254317-n2knqj4z 465 30 region region NN cord-254317-n2knqj4z 465 31 in in IN cord-254317-n2knqj4z 465 32 the the DT cord-254317-n2knqj4z 465 33 N N NNP cord-254317-n2knqj4z 465 34 - - HYPH cord-254317-n2knqj4z 465 35 Terminal Terminal NNP cord-254317-n2knqj4z 465 36 domain domain NN cord-254317-n2knqj4z 465 37 of of IN cord-254317-n2knqj4z 465 38 spike spike NN cord-254317-n2knqj4z 465 39 protein protein NN cord-254317-n2knqj4z 465 40 attenuates attenuate VBZ cord-254317-n2knqj4z 465 41 porcine porcine JJ cord-254317-n2knqj4z 465 42 epidemic epidemic NN cord-254317-n2knqj4z 465 43 diarrhea diarrhea NN cord-254317-n2knqj4z 465 44 virus virus NN cord-254317-n2knqj4z 465 45 in in IN cord-254317-n2knqj4z 465 46 piglets piglet NNS cord-254317-n2knqj4z 466 1 The the DT cord-254317-n2knqj4z 466 2 deletion deletion NN cord-254317-n2knqj4z 466 3 of of IN cord-254317-n2knqj4z 466 4 both both DT cord-254317-n2knqj4z 466 5 tyrosinebased tyrosinebase VBN cord-254317-n2knqj4z 466 6 endocytosis endocytosis NN cord-254317-n2knqj4z 466 7 signal signal NN cord-254317-n2knqj4z 466 8 and and CC cord-254317-n2knqj4z 466 9 endoplasmic endoplasmic NN cord-254317-n2knqj4z 466 10 reticulum reticulum NN cord-254317-n2knqj4z 466 11 - - HYPH cord-254317-n2knqj4z 466 12 retrieval retrieval NN cord-254317-n2knqj4z 466 13 signal signal NN cord-254317-n2knqj4z 466 14 in in IN cord-254317-n2knqj4z 466 15 the the DT cord-254317-n2knqj4z 466 16 cytoplasmic cytoplasmic JJ cord-254317-n2knqj4z 466 17 tail tail NN cord-254317-n2knqj4z 466 18 of of IN cord-254317-n2knqj4z 466 19 spike spike NN cord-254317-n2knqj4z 466 20 protein protein NN cord-254317-n2knqj4z 466 21 attenuates attenuate VBZ cord-254317-n2knqj4z 466 22 PEDV PEDV NNP cord-254317-n2knqj4z 466 23 in in IN cord-254317-n2knqj4z 466 24 pigs pig NNS cord-254317-n2knqj4z 466 25 Pathology Pathology NNP cord-254317-n2knqj4z 466 26 of of IN cord-254317-n2knqj4z 466 27 US US NNP cord-254317-n2knqj4z 466 28 porcine porcine JJ cord-254317-n2knqj4z 466 29 epidemic epidemic NN cord-254317-n2knqj4z 466 30 diarrhea diarrhea NN cord-254317-n2knqj4z 466 31 virus virus NN cord-254317-n2knqj4z 467 1 strain strain NN cord-254317-n2knqj4z 467 2 PC21A pc21a JJ cord-254317-n2knqj4z 467 3 in in IN cord-254317-n2knqj4z 467 4 gnotobiotic gnotobiotic JJ cord-254317-n2knqj4z 467 5 pigs pig NNS cord-254317-n2knqj4z 468 1 Trypsin Trypsin NNP cord-254317-n2knqj4z 468 2 - - HYPH cord-254317-n2knqj4z 468 3 independent independent JJ cord-254317-n2knqj4z 468 4 porcine porcine JJ cord-254317-n2knqj4z 468 5 epidemic epidemic NN cord-254317-n2knqj4z 468 6 diarrhea diarrhea NN cord-254317-n2knqj4z 468 7 virus virus NN cord-254317-n2knqj4z 468 8 US US NNP cord-254317-n2knqj4z 468 9 strain strain VB cord-254317-n2knqj4z 468 10 with with IN cord-254317-n2knqj4z 468 11 altered alter VBN cord-254317-n2knqj4z 468 12 virus virus NN cord-254317-n2knqj4z 468 13 entry entry NN cord-254317-n2knqj4z 468 14 mechanism mechanism NN cord-254317-n2knqj4z 468 15 Point point NN cord-254317-n2knqj4z 468 16 mutations mutation NNS cord-254317-n2knqj4z 468 17 in in IN cord-254317-n2knqj4z 468 18 the the DT cord-254317-n2knqj4z 468 19 S S NNP cord-254317-n2knqj4z 468 20 protein protein NN cord-254317-n2knqj4z 468 21 connect connect VBP cord-254317-n2knqj4z 468 22 the the DT cord-254317-n2knqj4z 468 23 sialic sialic JJ cord-254317-n2knqj4z 468 24 acid acid NN cord-254317-n2knqj4z 468 25 binding bind VBG cord-254317-n2knqj4z 468 26 activity activity NN cord-254317-n2knqj4z 468 27 with with IN cord-254317-n2knqj4z 468 28 the the DT cord-254317-n2knqj4z 468 29 enteropathogenicity enteropathogenicity NN cord-254317-n2knqj4z 468 30 of of IN cord-254317-n2knqj4z 468 31 transmissible transmissible JJ cord-254317-n2knqj4z 468 32 gastroenteritis gastroenteritis NN cord-254317-n2knqj4z 468 33 coronavirus coronavirus NN cord-254317-n2knqj4z 468 34 Characterization characterization NN cord-254317-n2knqj4z 468 35 of of IN cord-254317-n2knqj4z 468 36 the the DT cord-254317-n2knqj4z 468 37 sialic sialic JJ cord-254317-n2knqj4z 468 38 acid acid NN cord-254317-n2knqj4z 468 39 binding bind VBG cord-254317-n2knqj4z 468 40 activity activity NN cord-254317-n2knqj4z 468 41 of of IN cord-254317-n2knqj4z 468 42 transmissible transmissible JJ cord-254317-n2knqj4z 468 43 gastroenteritis gastroenteritis NN cord-254317-n2knqj4z 468 44 coronavirus coronavirus NN cord-254317-n2knqj4z 468 45 by by IN cord-254317-n2knqj4z 468 46 analysis analysis NN cord-254317-n2knqj4z 468 47 of of IN cord-254317-n2knqj4z 468 48 haemagglutination haemagglutination NN cord-254317-n2knqj4z 468 49 - - HYPH cord-254317-n2knqj4z 468 50 deficient deficient JJ cord-254317-n2knqj4z 468 51 mutants mutant NNS cord-254317-n2knqj4z 468 52 Structure Structure NNP cord-254317-n2knqj4z 468 53 , , , cord-254317-n2knqj4z 468 54 function function NN cord-254317-n2knqj4z 468 55 , , , cord-254317-n2knqj4z 468 56 and and CC cord-254317-n2knqj4z 468 57 evolution evolution NN cord-254317-n2knqj4z 468 58 of of IN cord-254317-n2knqj4z 468 59 coronavirus coronavirus NN cord-254317-n2knqj4z 468 60 spike spike NN cord-254317-n2knqj4z 468 61 proteins protein NNS cord-254317-n2knqj4z 469 1 Cellular cellular JJ cord-254317-n2knqj4z 469 2 entry entry NN cord-254317-n2knqj4z 469 3 of of IN cord-254317-n2knqj4z 469 4 the the DT cord-254317-n2knqj4z 469 5 porcine porcine JJ cord-254317-n2knqj4z 469 6 epidemic epidemic NN cord-254317-n2knqj4z 469 7 diarrhea diarrhea NN cord-254317-n2knqj4z 469 8 virus virus NN cord-254317-n2knqj4z 469 9 Cell cell NN cord-254317-n2knqj4z 469 10 attachment attachment NN cord-254317-n2knqj4z 469 11 domains domain NNS cord-254317-n2knqj4z 469 12 of of IN cord-254317-n2knqj4z 469 13 the the DT cord-254317-n2knqj4z 469 14 porcine porcine JJ cord-254317-n2knqj4z 469 15 epidemic epidemic NN cord-254317-n2knqj4z 469 16 diarrhea diarrhea NN cord-254317-n2knqj4z 469 17 virus virus NN cord-254317-n2knqj4z 469 18 spike spike NN cord-254317-n2knqj4z 469 19 protein protein NN cord-254317-n2knqj4z 469 20 are be VBP cord-254317-n2knqj4z 469 21 key key JJ cord-254317-n2knqj4z 469 22 targets target NNS cord-254317-n2knqj4z 469 23 of of IN cord-254317-n2knqj4z 469 24 neutralizing neutralize VBG cord-254317-n2knqj4z 469 25 antibodies antibody NNS cord-254317-n2knqj4z 470 1 Aminopeptidase Aminopeptidase NNP cord-254317-n2knqj4z 470 2 N N NNP cord-254317-n2knqj4z 470 3 is be VBZ cord-254317-n2knqj4z 470 4 not not RB cord-254317-n2knqj4z 470 5 required require VBN cord-254317-n2knqj4z 470 6 for for IN cord-254317-n2knqj4z 470 7 porcine porcine JJ cord-254317-n2knqj4z 470 8 epidemic epidemic NN cord-254317-n2knqj4z 470 9 diarrhea diarrhea NN cord-254317-n2knqj4z 470 10 virus virus NN cord-254317-n2knqj4z 470 11 cell cell NN cord-254317-n2knqj4z 470 12 entry entry NN cord-254317-n2knqj4z 470 13 Bile bile NN cord-254317-n2knqj4z 470 14 - - HYPH cord-254317-n2knqj4z 470 15 salts salt NNS cord-254317-n2knqj4z 470 16 in in IN cord-254317-n2knqj4z 470 17 small small JJ cord-254317-n2knqj4z 470 18 intestinal intestinal JJ cord-254317-n2knqj4z 470 19 contents content NNS cord-254317-n2knqj4z 470 20 after after IN cord-254317-n2knqj4z 470 21 ileal ileal JJ cord-254317-n2knqj4z 470 22 resection resection NN cord-254317-n2knqj4z 470 23 and and CC cord-254317-n2knqj4z 470 24 in in IN cord-254317-n2knqj4z 470 25 other other JJ cord-254317-n2knqj4z 470 26 malabsorption malabsorption NN cord-254317-n2knqj4z 470 27 syndromes syndrome VBZ cord-254317-n2knqj4z 470 28 Swine swine JJ cord-254317-n2knqj4z 470 29 enteric enteric JJ cord-254317-n2knqj4z 470 30 coronavirus coronavirus NN cord-254317-n2knqj4z 470 31 disease disease NN cord-254317-n2knqj4z 470 32 : : : cord-254317-n2knqj4z 470 33 A a DT cord-254317-n2knqj4z 470 34 review review NN cord-254317-n2knqj4z 470 35 of of IN cord-254317-n2knqj4z 470 36 4 4 CD cord-254317-n2knqj4z 470 37 years year NNS cord-254317-n2knqj4z 470 38 with with IN cord-254317-n2knqj4z 470 39 porcine porcine JJ cord-254317-n2knqj4z 470 40 epidemic epidemic NN cord-254317-n2knqj4z 470 41 diarrhoea diarrhoea NN cord-254317-n2knqj4z 470 42 virus virus NN cord-254317-n2knqj4z 470 43 and and CC cord-254317-n2knqj4z 470 44 porcine porcine JJ cord-254317-n2knqj4z 470 45 deltacoronavirus deltacoronavirus NN cord-254317-n2knqj4z 470 46 in in IN cord-254317-n2knqj4z 470 47 the the DT cord-254317-n2knqj4z 470 48 United United NNP cord-254317-n2knqj4z 470 49 States States NNP cord-254317-n2knqj4z 470 50 and and CC cord-254317-n2knqj4z 470 51 Canada Canada NNP cord-254317-n2knqj4z 470 52 Cell Cell NNP cord-254317-n2knqj4z 470 53 culture culture NN cord-254317-n2knqj4z 470 54 isolation isolation NN cord-254317-n2knqj4z 470 55 and and CC cord-254317-n2knqj4z 470 56 sequence sequence NN cord-254317-n2knqj4z 470 57 analysis analysis NN cord-254317-n2knqj4z 470 58 of of IN cord-254317-n2knqj4z 470 59 genetically genetically RB cord-254317-n2knqj4z 470 60 diverse diverse JJ cord-254317-n2knqj4z 470 61 US US NNP cord-254317-n2knqj4z 470 62 porcine porcine JJ cord-254317-n2knqj4z 470 63 epidemic epidemic NN cord-254317-n2knqj4z 470 64 diarrhea diarrhea NN cord-254317-n2knqj4z 470 65 virus virus NN cord-254317-n2knqj4z 470 66 strains strain VBZ cord-254317-n2knqj4z 470 67 including include VBG cord-254317-n2knqj4z 470 68 a a DT cord-254317-n2knqj4z 470 69 novel novel JJ cord-254317-n2knqj4z 470 70 strain strain NN cord-254317-n2knqj4z 470 71 with with IN cord-254317-n2knqj4z 470 72 a a DT cord-254317-n2knqj4z 470 73 large large JJ cord-254317-n2knqj4z 470 74 deletion deletion NN cord-254317-n2knqj4z 470 75 in in IN cord-254317-n2knqj4z 470 76 the the DT cord-254317-n2knqj4z 470 77 spike spike NN cord-254317-n2knqj4z 470 78 gene gene NN cord-254317-n2knqj4z 470 79 A a DT cord-254317-n2knqj4z 470 80 simple simple JJ cord-254317-n2knqj4z 470 81 method method NN cord-254317-n2knqj4z 470 82 of of IN cord-254317-n2knqj4z 470 83 estimating estimate VBG cord-254317-n2knqj4z 470 84 fifty fifty CD cord-254317-n2knqj4z 470 85 percent percent NN cord-254317-n2knqj4z 470 86 endpoints endpoint NNS cord-254317-n2knqj4z 471 1 The the DT cord-254317-n2knqj4z 471 2 gnotobiotic gnotobiotic JJ cord-254317-n2knqj4z 471 3 piglet piglet NN cord-254317-n2knqj4z 471 4 as as IN cord-254317-n2knqj4z 471 5 a a DT cord-254317-n2knqj4z 471 6 model model NN cord-254317-n2knqj4z 471 7 for for IN cord-254317-n2knqj4z 471 8 studies study NNS cord-254317-n2knqj4z 471 9 of of IN cord-254317-n2knqj4z 471 10 disease disease NN cord-254317-n2knqj4z 471 11 pathogenesis pathogenesis NN cord-254317-n2knqj4z 471 12 and and CC cord-254317-n2knqj4z 471 13 immunity immunity NN cord-254317-n2knqj4z 471 14 to to IN cord-254317-n2knqj4z 471 15 human human JJ cord-254317-n2knqj4z 471 16 rotaviruses rotavirus NNS cord-254317-n2knqj4z 471 17 Transmissible transmissible JJ cord-254317-n2knqj4z 471 18 gastroenteritis gastroenteritis NN cord-254317-n2knqj4z 471 19 coronavirus coronavirus NN cord-254317-n2knqj4z 471 20 , , , cord-254317-n2knqj4z 471 21 but but CC cord-254317-n2knqj4z 471 22 not not RB cord-254317-n2knqj4z 471 23 the the DT cord-254317-n2knqj4z 471 24 related related JJ cord-254317-n2knqj4z 471 25 porcine porcine JJ cord-254317-n2knqj4z 471 26 respiratory respiratory JJ cord-254317-n2knqj4z 471 27 coronavirus coronavirus NN cord-254317-n2knqj4z 471 28 , , , cord-254317-n2knqj4z 471 29 has have VBZ cord-254317-n2knqj4z 471 30 a a DT cord-254317-n2knqj4z 471 31 sialic sialic JJ cord-254317-n2knqj4z 471 32 acid acid NN cord-254317-n2knqj4z 471 33 ( ( -LRB- cord-254317-n2knqj4z 471 34 N N NNP cord-254317-n2knqj4z 471 35 - - HYPH cord-254317-n2knqj4z 471 36 glycolylneuraminic glycolylneuraminic NN cord-254317-n2knqj4z 471 37 acid acid NN cord-254317-n2knqj4z 471 38 ) ) -RRB- cord-254317-n2knqj4z 471 39 binding bind VBG cord-254317-n2knqj4z 471 40 activity activity NN cord-254317-n2knqj4z 472 1 Sialic Sialic NNP cord-254317-n2knqj4z 472 2 acids acid NNS cord-254317-n2knqj4z 472 3 as as IN cord-254317-n2knqj4z 472 4 receptor receptor NN cord-254317-n2knqj4z 472 5 determinants determinant NNS cord-254317-n2knqj4z 472 6 for for IN cord-254317-n2knqj4z 472 7 coronaviruses coronaviruse NNS cord-254317-n2knqj4z 473 1 The the DT cord-254317-n2knqj4z 473 2 sialic sialic JJ cord-254317-n2knqj4z 473 3 acid acid NN cord-254317-n2knqj4z 473 4 binding bind VBG cord-254317-n2knqj4z 473 5 activity activity NN cord-254317-n2knqj4z 473 6 of of IN cord-254317-n2knqj4z 473 7 the the DT cord-254317-n2knqj4z 473 8 S S NNP cord-254317-n2knqj4z 473 9 protein protein NN cord-254317-n2knqj4z 473 10 facilitates facilitate VBZ cord-254317-n2knqj4z 473 11 infection infection NN cord-254317-n2knqj4z 473 12 by by IN cord-254317-n2knqj4z 473 13 porcine porcine JJ cord-254317-n2knqj4z 473 14 transmissible transmissible JJ cord-254317-n2knqj4z 473 15 gastroenteritis gastroenteritis NN cord-254317-n2knqj4z 473 16 coronavirus coronavirus NN cord-254317-n2knqj4z 473 17 Porcine porcine JJ cord-254317-n2knqj4z 473 18 aminopeptidase aminopeptidase NN cord-254317-n2knqj4z 474 1 N N NNP cord-254317-n2knqj4z 474 2 is be VBZ cord-254317-n2knqj4z 474 3 not not RB cord-254317-n2knqj4z 474 4 a a DT cord-254317-n2knqj4z 474 5 cellular cellular JJ cord-254317-n2knqj4z 474 6 receptor receptor NN cord-254317-n2knqj4z 474 7 of of IN cord-254317-n2knqj4z 474 8 porcine porcine JJ cord-254317-n2knqj4z 474 9 epidemic epidemic NN cord-254317-n2knqj4z 474 10 diarrhea diarrhea NN cord-254317-n2knqj4z 474 11 virus virus NN cord-254317-n2knqj4z 474 12 , , , cord-254317-n2knqj4z 474 13 but but CC cord-254317-n2knqj4z 474 14 promotes promote VBZ cord-254317-n2knqj4z 474 15 its -PRON- PRP$ cord-254317-n2knqj4z 474 16 infectivity infectivity NN cord-254317-n2knqj4z 474 17 via via IN cord-254317-n2knqj4z 474 18 aminopeptidase aminopeptidase NN cord-254317-n2knqj4z 474 19 activity activity NN cord-254317-n2knqj4z 474 20 New new JJ cord-254317-n2knqj4z 474 21 variants variant NNS cord-254317-n2knqj4z 474 22 of of IN cord-254317-n2knqj4z 474 23 porcine porcine JJ cord-254317-n2knqj4z 474 24 epidemic epidemic NN cord-254317-n2knqj4z 474 25 diarrhea diarrhea NN cord-254317-n2knqj4z 474 26 virus virus NN cord-254317-n2knqj4z 474 27 with with IN cord-254317-n2knqj4z 474 28 large large JJ cord-254317-n2knqj4z 474 29 deletions deletion NNS cord-254317-n2knqj4z 474 30 in in IN cord-254317-n2knqj4z 474 31 the the DT cord-254317-n2knqj4z 474 32 spike spike NN cord-254317-n2knqj4z 474 33 protein protein NN cord-254317-n2knqj4z 474 34 , , , cord-254317-n2knqj4z 474 35 identified identify VBN cord-254317-n2knqj4z 474 36 in in IN cord-254317-n2knqj4z 474 37 the the DT cord-254317-n2knqj4z 474 38 United United NNP cord-254317-n2knqj4z 474 39 States States NNP cord-254317-n2knqj4z 474 40 Molecular Molecular NNP cord-254317-n2knqj4z 474 41 characterization characterization NN cord-254317-n2knqj4z 474 42 of of IN cord-254317-n2knqj4z 474 43 pig pig NN cord-254317-n2knqj4z 474 44 epidemic epidemic NN cord-254317-n2knqj4z 474 45 diarrhoea diarrhoea NN cord-254317-n2knqj4z 474 46 viruses virus NNS cord-254317-n2knqj4z 474 47 isolated isolate VBN cord-254317-n2knqj4z 474 48 in in IN cord-254317-n2knqj4z 474 49 Japan Japan NNP cord-254317-n2knqj4z 474 50 from from IN cord-254317-n2knqj4z 474 51 Pig Pig NNP cord-254317-n2knqj4z 474 52 epidemic epidemic NN cord-254317-n2knqj4z 474 53 diarrhoea diarrhoea NN cord-254317-n2knqj4z 474 54 virus virus NN cord-254317-n2knqj4z 474 55 S s NN cord-254317-n2knqj4z 474 56 gene gene NN cord-254317-n2knqj4z 474 57 variant variant NN cord-254317-n2knqj4z 474 58 with with IN cord-254317-n2knqj4z 474 59 a a DT cord-254317-n2knqj4z 474 60 large large JJ cord-254317-n2knqj4z 474 61 deletion deletion NN cord-254317-n2knqj4z 474 62 non non JJ cord-254317-n2knqj4z 474 63 - - JJ cord-254317-n2knqj4z 474 64 lethal lethal JJ cord-254317-n2knqj4z 474 65 to to IN cord-254317-n2knqj4z 474 66 colostrum colostrum NN cord-254317-n2knqj4z 474 67 - - HYPH cord-254317-n2knqj4z 474 68 deprived deprive VBN cord-254317-n2knqj4z 474 69 newborn newborn JJ cord-254317-n2knqj4z 474 70 piglets piglet NNS cord-254317-n2knqj4z 474 71 Deciphering decipher VBG cord-254317-n2knqj4z 474 72 the the DT cord-254317-n2knqj4z 474 73 biology biology NN cord-254317-n2knqj4z 474 74 of of IN cord-254317-n2knqj4z 474 75 porcine porcine JJ cord-254317-n2knqj4z 474 76 epidemic epidemic NN cord-254317-n2knqj4z 474 77 diarrhea diarrhea NN cord-254317-n2knqj4z 474 78 virus virus NN cord-254317-n2knqj4z 474 79 in in IN cord-254317-n2knqj4z 474 80 the the DT cord-254317-n2knqj4z 474 81 era era NN cord-254317-n2knqj4z 474 82 of of IN cord-254317-n2knqj4z 474 83 reverse reverse JJ cord-254317-n2knqj4z 474 84 genetics genetics NN cord-254317-n2knqj4z 474 85 Contribution Contribution NNP cord-254317-n2knqj4z 474 86 of of IN cord-254317-n2knqj4z 474 87 antibody antibody NN cord-254317-n2knqj4z 474 88 - - HYPH cord-254317-n2knqj4z 474 89 secreting secrete VBG cord-254317-n2knqj4z 474 90 cells cell NNS cord-254317-n2knqj4z 474 91 induced induce VBN cord-254317-n2knqj4z 474 92 in in IN cord-254317-n2knqj4z 474 93 mucosal mucosal JJ cord-254317-n2knqj4z 474 94 lymphoid lymphoid JJ cord-254317-n2knqj4z 474 95 tissues tissue NNS cord-254317-n2knqj4z 474 96 of of IN cord-254317-n2knqj4z 474 97 pigs pig NNS cord-254317-n2knqj4z 474 98 inoculated inoculate VBN cord-254317-n2knqj4z 474 99 with with IN cord-254317-n2knqj4z 474 100 respiratory respiratory JJ cord-254317-n2knqj4z 474 101 or or CC cord-254317-n2knqj4z 474 102 enteric enteric JJ cord-254317-n2knqj4z 474 103 strains strain NNS cord-254317-n2knqj4z 474 104 of of IN cord-254317-n2knqj4z 474 105 coronavirus coronavirus NN cord-254317-n2knqj4z 474 106 to to IN cord-254317-n2knqj4z 474 107 immunity immunity NN cord-254317-n2knqj4z 474 108 against against IN cord-254317-n2knqj4z 474 109 enteric enteric JJ cord-254317-n2knqj4z 474 110 coronavirus coronavirus NN cord-254317-n2knqj4z 474 111 challenge challenge NN cord-254317-n2knqj4z 474 112 Complete complete JJ cord-254317-n2knqj4z 474 113 genomic genomic JJ cord-254317-n2knqj4z 474 114 sequences sequence NNS cord-254317-n2knqj4z 474 115 , , , cord-254317-n2knqj4z 474 116 a a DT cord-254317-n2knqj4z 474 117 key key JJ cord-254317-n2knqj4z 474 118 residue residue NN cord-254317-n2knqj4z 474 119 in in IN cord-254317-n2knqj4z 474 120 the the DT cord-254317-n2knqj4z 474 121 spike spike NN cord-254317-n2knqj4z 474 122 protein protein NN cord-254317-n2knqj4z 474 123 and and CC cord-254317-n2knqj4z 474 124 deletions deletion NNS cord-254317-n2knqj4z 474 125 in in IN cord-254317-n2knqj4z 474 126 nonstructural nonstructural JJ cord-254317-n2knqj4z 474 127 protein protein NN cord-254317-n2knqj4z 474 128 3b 3b CD cord-254317-n2knqj4z 474 129 of of IN cord-254317-n2knqj4z 474 130 US US NNP cord-254317-n2knqj4z 474 131 strains strain NNS cord-254317-n2knqj4z 474 132 of of IN cord-254317-n2knqj4z 474 133 the the DT cord-254317-n2knqj4z 474 134 virulent virulent JJ cord-254317-n2knqj4z 474 135 and and CC cord-254317-n2knqj4z 474 136 attenuated attenuated JJ cord-254317-n2knqj4z 474 137 coronaviruses coronaviruse NNS cord-254317-n2knqj4z 474 138 , , , cord-254317-n2knqj4z 474 139 transmissible transmissible JJ cord-254317-n2knqj4z 474 140 gastroenteritis gastroenteritis NN cord-254317-n2knqj4z 474 141 virus virus NN cord-254317-n2knqj4z 474 142 and and CC cord-254317-n2knqj4z 474 143 porcine porcine JJ cord-254317-n2knqj4z 474 144 respiratory respiratory JJ cord-254317-n2knqj4z 474 145 coronavirus coronavirus NN cord-254317-n2knqj4z 474 146 Identification identification NN cord-254317-n2knqj4z 474 147 of of IN cord-254317-n2knqj4z 474 148 porcine porcine JJ cord-254317-n2knqj4z 474 149 epidemic epidemic NN cord-254317-n2knqj4z 474 150 diarrhea diarrhea NN cord-254317-n2knqj4z 474 151 virus virus NN cord-254317-n2knqj4z 474 152 variant variant NN cord-254317-n2knqj4z 474 153 with with IN cord-254317-n2knqj4z 474 154 a a DT cord-254317-n2knqj4z 474 155 large large JJ cord-254317-n2knqj4z 474 156 spike spike NN cord-254317-n2knqj4z 474 157 gene gene NN cord-254317-n2knqj4z 474 158 deletion deletion NN cord-254317-n2knqj4z 474 159 from from IN cord-254317-n2knqj4z 474 160 a a DT cord-254317-n2knqj4z 474 161 clinical clinical JJ cord-254317-n2knqj4z 474 162 swine swine NN cord-254317-n2knqj4z 474 163 sample sample NN cord-254317-n2knqj4z 474 164 in in IN cord-254317-n2knqj4z 474 165 the the DT cord-254317-n2knqj4z 474 166 United United NNP cord-254317-n2knqj4z 474 167 States States NNP cord-254317-n2knqj4z 474 168 Type Type NNP cord-254317-n2knqj4z 474 169 III III NNP cord-254317-n2knqj4z 475 1 interferon interferon NN cord-254317-n2knqj4z 475 2 restriction restriction NN cord-254317-n2knqj4z 475 3 by by IN cord-254317-n2knqj4z 475 4 porcine porcine JJ cord-254317-n2knqj4z 475 5 epidemic epidemic NN cord-254317-n2knqj4z 475 6 diarrhea diarrhea NN cord-254317-n2knqj4z 475 7 virus virus NN cord-254317-n2knqj4z 475 8 and and CC cord-254317-n2knqj4z 475 9 the the DT cord-254317-n2knqj4z 475 10 role role NN cord-254317-n2knqj4z 475 11 of of IN cord-254317-n2knqj4z 475 12 viral viral JJ cord-254317-n2knqj4z 475 13 protein protein NN cord-254317-n2knqj4z 475 14 nsp1 nsp1 NNS cord-254317-n2knqj4z 475 15 in in IN cord-254317-n2knqj4z 475 16 IRF1 IRF1 NNP cord-254317-n2knqj4z 475 17 signaling signal VBG cord-254317-n2knqj4z 475 18 The the DT cord-254317-n2knqj4z 475 19 authors author NNS cord-254317-n2knqj4z 475 20 declare declare VBP cord-254317-n2knqj4z 475 21 no no DT cord-254317-n2knqj4z 475 22 conflict conflict NN cord-254317-n2knqj4z 475 23 of of IN cord-254317-n2knqj4z 475 24 interest interest NN cord-254317-n2knqj4z 475 25 . . . cord-254317-n2knqj4z 476 1 None none NN cord-254317-n2knqj4z 476 2 . . . cord-254317-n2knqj4z 477 1 Supplementary supplementary JJ cord-254317-n2knqj4z 477 2 material material NN cord-254317-n2knqj4z 477 3 related relate VBN cord-254317-n2knqj4z 477 4 to to IN cord-254317-n2knqj4z 477 5 this this DT cord-254317-n2knqj4z 477 6 article article NN cord-254317-n2knqj4z 477 7 can can MD cord-254317-n2knqj4z 477 8 be be VB cord-254317-n2knqj4z 477 9 found find VBN cord-254317-n2knqj4z 477 10 , , , cord-254317-n2knqj4z 477 11 in in IN cord-254317-n2knqj4z 477 12 the the DT cord-254317-n2knqj4z 477 13 online online JJ cord-254317-n2knqj4z 477 14 version version NN cord-254317-n2knqj4z 477 15 , , , cord-254317-n2knqj4z 477 16 at at IN cord-254317-n2knqj4z 477 17 doi doi NNP cord-254317-n2knqj4z 477 18 : : : cord-254317-n2knqj4z 477 19 https://doi.org/10.1016 https://doi.org/10.1016 NNP cord-254317-n2knqj4z 477 20 / / SYM cord-254317-n2knqj4z 477 21 j.vetmic.2018.11.025 j.vetmic.2018.11.025 NNP cord-254317-n2knqj4z 477 22 . . .