id sid tid token lemma pos cord-286607-5i406twr 1 1 key key JJ cord-286607-5i406twr 1 2 : : : cord-286607-5i406twr 1 3 cord-286607 cord-286607 NNP cord-286607-5i406twr 1 4 - - HYPH cord-286607-5i406twr 1 5 5i406twr 5i406twr CD cord-286607-5i406twr 1 6 authors author NNS cord-286607-5i406twr 1 7 : : : cord-286607-5i406twr 1 8 Esposito Esposito NNP cord-286607-5i406twr 1 9 , , , cord-286607-5i406twr 1 10 Susanna Susanna NNP cord-286607-5i406twr 1 11 ; ; : cord-286607-5i406twr 1 12 Polinori Polinori NNP cord-286607-5i406twr 1 13 , , , cord-286607-5i406twr 1 14 Ilaria Ilaria NNP cord-286607-5i406twr 1 15 ; ; : cord-286607-5i406twr 1 16 Rigante Rigante NNP cord-286607-5i406twr 1 17 , , , cord-286607-5i406twr 2 1 Donato Donato NNP cord-286607-5i406twr 2 2 title title NN cord-286607-5i406twr 2 3 : : : cord-286607-5i406twr 3 1 The the DT cord-286607-5i406twr 3 2 Gut Gut NNP cord-286607-5i406twr 3 3 Microbiota Microbiota NNP cord-286607-5i406twr 3 4 - - HYPH cord-286607-5i406twr 3 5 Host Host NNP cord-286607-5i406twr 3 6 Partnership Partnership NNP cord-286607-5i406twr 3 7 as as IN cord-286607-5i406twr 3 8 a a DT cord-286607-5i406twr 3 9 Potential Potential NNP cord-286607-5i406twr 3 10 Driver Driver NNP cord-286607-5i406twr 3 11 of of IN cord-286607-5i406twr 3 12 Kawasaki Kawasaki NNP cord-286607-5i406twr 3 13 Syndrome Syndrome NNP cord-286607-5i406twr 3 14 date date NN cord-286607-5i406twr 3 15 : : : cord-286607-5i406twr 3 16 2019 2019 CD cord-286607-5i406twr 3 17 - - HYPH cord-286607-5i406twr 3 18 04 04 CD cord-286607-5i406twr 3 19 - - HYPH cord-286607-5i406twr 3 20 05 05 CD cord-286607-5i406twr 3 21 journal journal NN cord-286607-5i406twr 3 22 : : : cord-286607-5i406twr 4 1 Front Front NNP cord-286607-5i406twr 4 2 Pediatr Pediatr NNP cord-286607-5i406twr 4 3 DOI DOI NNP cord-286607-5i406twr 4 4 : : : cord-286607-5i406twr 4 5 10.3389 10.3389 CD cord-286607-5i406twr 4 6 / / SYM cord-286607-5i406twr 4 7 fped.2019.00124 fped.2019.00124 CD cord-286607-5i406twr 4 8 sha sha NNP cord-286607-5i406twr 4 9 : : : cord-286607-5i406twr 4 10 c0713cd16ef0d30221483b314837bcf9e642a884 c0713cd16ef0d30221483b314837bcf9e642a884 . cord-286607-5i406twr 4 11 doc_id doc_id CD cord-286607-5i406twr 4 12 : : : cord-286607-5i406twr 4 13 286607 286607 CD cord-286607-5i406twr 4 14 cord_uid cord_uid NNS cord-286607-5i406twr 4 15 : : : cord-286607-5i406twr 5 1 5i406twr 5i406twr JJ cord-286607-5i406twr 5 2 Kawasaki Kawasaki NNP cord-286607-5i406twr 5 3 syndrome syndrome NN cord-286607-5i406twr 5 4 ( ( -LRB- cord-286607-5i406twr 5 5 KS KS NNP cord-286607-5i406twr 5 6 ) ) -RRB- cord-286607-5i406twr 5 7 is be VBZ cord-286607-5i406twr 5 8 a a DT cord-286607-5i406twr 5 9 necrotizing necrotize VBG cord-286607-5i406twr 5 10 vasculitis vasculitis NN cord-286607-5i406twr 5 11 of of IN cord-286607-5i406twr 5 12 small- small- JJ cord-286607-5i406twr 5 13 and and CC cord-286607-5i406twr 5 14 medium medium JJ cord-286607-5i406twr 5 15 - - HYPH cord-286607-5i406twr 5 16 sized sized JJ cord-286607-5i406twr 5 17 vessels vessel NNS cord-286607-5i406twr 5 18 mostly mostly RB cord-286607-5i406twr 5 19 affecting affect VBG cord-286607-5i406twr 5 20 children child NNS cord-286607-5i406twr 5 21 under under IN cord-286607-5i406twr 5 22 5 5 CD cord-286607-5i406twr 5 23 years year NNS cord-286607-5i406twr 5 24 of of IN cord-286607-5i406twr 5 25 age age NN cord-286607-5i406twr 5 26 ; ; : cord-286607-5i406twr 5 27 a a DT cord-286607-5i406twr 5 28 host host NN cord-286607-5i406twr 5 29 of of IN cord-286607-5i406twr 5 30 clinical clinical JJ cord-286607-5i406twr 5 31 and and CC cord-286607-5i406twr 5 32 epidemiological epidemiological JJ cord-286607-5i406twr 5 33 data data NN cord-286607-5i406twr 5 34 supports support VBZ cord-286607-5i406twr 5 35 the the DT cord-286607-5i406twr 5 36 notion notion NN cord-286607-5i406twr 5 37 that that IN cord-286607-5i406twr 5 38 KS KS NNP cord-286607-5i406twr 5 39 might may MD cord-286607-5i406twr 5 40 result result VB cord-286607-5i406twr 5 41 from from IN cord-286607-5i406twr 5 42 an an DT cord-286607-5i406twr 5 43 infectious infectious JJ cord-286607-5i406twr 5 44 disease disease NN cord-286607-5i406twr 5 45 . . . cord-286607-5i406twr 6 1 However however RB cord-286607-5i406twr 6 2 , , , cord-286607-5i406twr 6 3 many many JJ cord-286607-5i406twr 6 4 efforts effort NNS cord-286607-5i406twr 6 5 have have VBP cord-286607-5i406twr 6 6 failed fail VBN cord-286607-5i406twr 6 7 to to TO cord-286607-5i406twr 6 8 identify identify VB cord-286607-5i406twr 6 9 a a DT cord-286607-5i406twr 6 10 potentially potentially RB cord-286607-5i406twr 6 11 universal universal JJ cord-286607-5i406twr 6 12 trigger trigger NN cord-286607-5i406twr 6 13 of of IN cord-286607-5i406twr 6 14 KS KS NNP cord-286607-5i406twr 6 15 . . . cord-286607-5i406twr 7 1 The the DT cord-286607-5i406twr 7 2 contribution contribution NN cord-286607-5i406twr 7 3 of of IN cord-286607-5i406twr 7 4 the the DT cord-286607-5i406twr 7 5 intestinal intestinal JJ cord-286607-5i406twr 7 6 microbial microbial JJ cord-286607-5i406twr 7 7 community community NN cord-286607-5i406twr 7 8 — — : cord-286607-5i406twr 7 9 called call VBD cord-286607-5i406twr 7 10 the the DT cord-286607-5i406twr 7 11 “ " `` cord-286607-5i406twr 7 12 microbiota”—to microbiota”—to NNP cord-286607-5i406twr 7 13 KS KS NNP cord-286607-5i406twr 7 14 has have VBZ cord-286607-5i406twr 7 15 been be VBN cord-286607-5i406twr 7 16 evaluated evaluate VBN cord-286607-5i406twr 7 17 by by IN cord-286607-5i406twr 7 18 an an DT cord-286607-5i406twr 7 19 increasing increase VBG cord-286607-5i406twr 7 20 number number NN cord-286607-5i406twr 7 21 of of IN cord-286607-5i406twr 7 22 studies study NNS cord-286607-5i406twr 7 23 , , , cord-286607-5i406twr 7 24 though though IN cord-286607-5i406twr 7 25 limited limit VBN cord-286607-5i406twr 7 26 to to IN cord-286607-5i406twr 7 27 small small JJ cord-286607-5i406twr 7 28 cohorts cohort NNS cord-286607-5i406twr 7 29 of of IN cord-286607-5i406twr 7 30 patients patient NNS cord-286607-5i406twr 7 31 . . . cord-286607-5i406twr 8 1 Differences difference NNS cord-286607-5i406twr 8 2 in in IN cord-286607-5i406twr 8 3 the the DT cord-286607-5i406twr 8 4 microbiota microbiota NN cord-286607-5i406twr 8 5 composition composition NN cord-286607-5i406twr 8 6 were be VBD cord-286607-5i406twr 8 7 found find VBN cord-286607-5i406twr 8 8 in in IN cord-286607-5i406twr 8 9 children child NNS cord-286607-5i406twr 8 10 with with IN cord-286607-5i406twr 8 11 KS KS NNP cord-286607-5i406twr 8 12 , , , cord-286607-5i406twr 8 13 both both CC cord-286607-5i406twr 8 14 its -PRON- PRP$ cord-286607-5i406twr 8 15 acute acute JJ cord-286607-5i406twr 8 16 and and CC cord-286607-5i406twr 8 17 non non JJ cord-286607-5i406twr 8 18 - - JJ cord-286607-5i406twr 8 19 acute acute JJ cord-286607-5i406twr 8 20 phase phase NN cord-286607-5i406twr 8 21 , , , cord-286607-5i406twr 8 22 with with IN cord-286607-5i406twr 8 23 abnormal abnormal JJ cord-286607-5i406twr 8 24 colonization colonization NN cord-286607-5i406twr 8 25 by by IN cord-286607-5i406twr 8 26 Streptococcus Streptococcus NNP cord-286607-5i406twr 8 27 species specie NNS cord-286607-5i406twr 8 28 in in IN cord-286607-5i406twr 8 29 the the DT cord-286607-5i406twr 8 30 intestinal intestinal JJ cord-286607-5i406twr 8 31 tract tract NN cord-286607-5i406twr 8 32 and and CC cord-286607-5i406twr 8 33 a a DT cord-286607-5i406twr 8 34 wider wide JJR cord-286607-5i406twr 8 35 presence presence NN cord-286607-5i406twr 8 36 of of IN cord-286607-5i406twr 8 37 Gram gram NN cord-286607-5i406twr 8 38 - - HYPH cord-286607-5i406twr 8 39 positive positive JJ cord-286607-5i406twr 8 40 cocci coccus NNS cord-286607-5i406twr 8 41 in in IN cord-286607-5i406twr 8 42 jejunal jejunal JJ cord-286607-5i406twr 8 43 biopsies biopsy NNS cord-286607-5i406twr 8 44 . . . cord-286607-5i406twr 9 1 In in IN cord-286607-5i406twr 9 2 particular particular JJ cord-286607-5i406twr 9 3 , , , cord-286607-5i406twr 9 4 a a DT cord-286607-5i406twr 9 5 higher high JJR cord-286607-5i406twr 9 6 number number NN cord-286607-5i406twr 9 7 of of IN cord-286607-5i406twr 9 8 Gram gram NN cord-286607-5i406twr 9 9 - - HYPH cord-286607-5i406twr 9 10 positive positive JJ cord-286607-5i406twr 9 11 cocci coccus NNS cord-286607-5i406twr 9 12 ( ( -LRB- cord-286607-5i406twr 9 13 of of IN cord-286607-5i406twr 9 14 the the DT cord-286607-5i406twr 9 15 genera genera NNP cord-286607-5i406twr 9 16 Streptococcus Streptococcus NNP cord-286607-5i406twr 9 17 and and CC cord-286607-5i406twr 9 18 Staphylococcus Staphylococcus NNP cord-286607-5i406twr 9 19 ) ) -RRB- cord-286607-5i406twr 9 20 , , , cord-286607-5i406twr 9 21 Eubacterium Eubacterium NNP cord-286607-5i406twr 9 22 , , , cord-286607-5i406twr 9 23 Peptostreptococcus Peptostreptococcus NNP cord-286607-5i406twr 9 24 , , , cord-286607-5i406twr 9 25 and and CC cord-286607-5i406twr 9 26 HSP60-producing hsp60-produce VBG cord-286607-5i406twr 9 27 Gram gram NN cord-286607-5i406twr 9 28 - - HYPH cord-286607-5i406twr 9 29 negative negative JJ cord-286607-5i406twr 9 30 microbes microbe NNS cord-286607-5i406twr 9 31 have have VBP cord-286607-5i406twr 9 32 been be VBN cord-286607-5i406twr 9 33 found find VBN cord-286607-5i406twr 9 34 in in IN cord-286607-5i406twr 9 35 the the DT cord-286607-5i406twr 9 36 stools stool NNS cord-286607-5i406twr 9 37 of of IN cord-286607-5i406twr 9 38 KS KS NNP cord-286607-5i406twr 9 39 children child NNS cord-286607-5i406twr 9 40 , , , cord-286607-5i406twr 9 41 and and CC cord-286607-5i406twr 9 42 their -PRON- PRP$ cord-286607-5i406twr 9 43 effects effect NNS cord-286607-5i406twr 9 44 on on IN cord-286607-5i406twr 9 45 the the DT cord-286607-5i406twr 9 46 antigenic antigenic JJ cord-286607-5i406twr 9 47 repertoire repertoire NN cord-286607-5i406twr 9 48 of of IN cord-286607-5i406twr 9 49 specific specific JJ cord-286607-5i406twr 9 50 T t NN cord-286607-5i406twr 9 51 cells cell NNS cord-286607-5i406twr 9 52 and and CC cord-286607-5i406twr 9 53 Vβ2 Vβ2 VBD cord-286607-5i406twr 9 54 T T NNP cord-286607-5i406twr 9 55 cell cell NN cord-286607-5i406twr 9 56 expansion expansion NN cord-286607-5i406twr 9 57 have have VBP cord-286607-5i406twr 9 58 been be VBN cord-286607-5i406twr 9 59 assessed assess VBN cord-286607-5i406twr 9 60 . . . cord-286607-5i406twr 10 1 Conversely conversely RB cord-286607-5i406twr 10 2 , , , cord-286607-5i406twr 10 3 Lactobacilli Lactobacilli NNP cord-286607-5i406twr 10 4 were be VBD cord-286607-5i406twr 10 5 lacking lack VBG cord-286607-5i406twr 10 6 in in IN cord-286607-5i406twr 10 7 most most JJS cord-286607-5i406twr 10 8 children child NNS cord-286607-5i406twr 10 9 with with IN cord-286607-5i406twr 10 10 KS KS NNP cord-286607-5i406twr 10 11 compared compare VBN cord-286607-5i406twr 10 12 with with IN cord-286607-5i406twr 10 13 other other JJ cord-286607-5i406twr 10 14 febrile febrile JJ cord-286607-5i406twr 10 15 illnesses illness NNS cord-286607-5i406twr 10 16 and and CC cord-286607-5i406twr 10 17 healthy healthy JJ cord-286607-5i406twr 10 18 controls control NNS cord-286607-5i406twr 10 19 . . . cord-286607-5i406twr 11 1 All all DT cord-286607-5i406twr 11 2 studies study NNS cord-286607-5i406twr 11 3 available available JJ cord-286607-5i406twr 11 4 to to IN cord-286607-5i406twr 11 5 date date NN cord-286607-5i406twr 11 6 have have VBP cord-286607-5i406twr 11 7 confirmed confirm VBN cord-286607-5i406twr 11 8 that that IN cord-286607-5i406twr 11 9 an an DT cord-286607-5i406twr 11 10 imbalance imbalance NN cord-286607-5i406twr 11 11 in in IN cord-286607-5i406twr 11 12 the the DT cord-286607-5i406twr 11 13 gut gut NN cord-286607-5i406twr 11 14 microbiota microbiota NN cord-286607-5i406twr 11 15 might may MD cord-286607-5i406twr 11 16 indirectly indirectly RB cord-286607-5i406twr 11 17 interfere interfere VB cord-286607-5i406twr 11 18 with with IN cord-286607-5i406twr 11 19 the the DT cord-286607-5i406twr 11 20 normal normal JJ cord-286607-5i406twr 11 21 function function NN cord-286607-5i406twr 11 22 of of IN cord-286607-5i406twr 11 23 innate innate JJ cord-286607-5i406twr 11 24 and and CC cord-286607-5i406twr 11 25 adaptive adaptive JJ cord-286607-5i406twr 11 26 immunity immunity NN cord-286607-5i406twr 11 27 , , , cord-286607-5i406twr 11 28 and and CC cord-286607-5i406twr 11 29 that that IN cord-286607-5i406twr 11 30 variable variable JJ cord-286607-5i406twr 11 31 microbiota microbiota NN cord-286607-5i406twr 11 32 interactions interaction NNS cord-286607-5i406twr 11 33 with with IN cord-286607-5i406twr 11 34 environmental environmental JJ cord-286607-5i406twr 11 35 factors factor NNS cord-286607-5i406twr 11 36 , , , cord-286607-5i406twr 11 37 mainly mainly RB cord-286607-5i406twr 11 38 infectious infectious JJ cord-286607-5i406twr 11 39 agents agent NNS cord-286607-5i406twr 11 40 , , , cord-286607-5i406twr 11 41 might may MD cord-286607-5i406twr 11 42 selectively selectively RB cord-286607-5i406twr 11 43 drive drive VB cord-286607-5i406twr 11 44 the the DT cord-286607-5i406twr 11 45 development development NN cord-286607-5i406twr 11 46 of of IN cord-286607-5i406twr 11 47 KS KS NNP cord-286607-5i406twr 11 48 in in IN cord-286607-5i406twr 11 49 genetically genetically RB cord-286607-5i406twr 11 50 susceptible susceptible JJ cord-286607-5i406twr 11 51 children child NNS cord-286607-5i406twr 11 52 . . . cord-286607-5i406twr 12 1 Further further JJ cord-286607-5i406twr 12 2 investigations investigation NNS cord-286607-5i406twr 12 3 of of IN cord-286607-5i406twr 12 4 the the DT cord-286607-5i406twr 12 5 intestinal intestinal JJ cord-286607-5i406twr 12 6 microflora microflora NN cord-286607-5i406twr 12 7 in in IN cord-286607-5i406twr 12 8 larger large JJR cord-286607-5i406twr 12 9 cohorts cohort NNS cord-286607-5i406twr 12 10 of of IN cord-286607-5i406twr 12 11 KS KS NNP cord-286607-5i406twr 12 12 patients patient NNS cord-286607-5i406twr 12 13 will will MD cord-286607-5i406twr 12 14 provide provide VB cord-286607-5i406twr 12 15 clues clue NNS cord-286607-5i406twr 12 16 to to TO cord-286607-5i406twr 12 17 disentangle disentangle VB cord-286607-5i406twr 12 18 the the DT cord-286607-5i406twr 12 19 pathogenesis pathogenesis NN cord-286607-5i406twr 12 20 of of IN cord-286607-5i406twr 12 21 this this DT cord-286607-5i406twr 12 22 disease disease NN cord-286607-5i406twr 12 23 and and CC cord-286607-5i406twr 12 24 probably probably RB cord-286607-5i406twr 12 25 indicate indicate VBP cord-286607-5i406twr 12 26 disease disease NN cord-286607-5i406twr 12 27 - - HYPH cord-286607-5i406twr 12 28 modifying modify VBG cord-286607-5i406twr 12 29 agents agent NNS cord-286607-5i406twr 12 30 or or CC cord-286607-5i406twr 12 31 more more RBR cord-286607-5i406twr 12 32 rational rational JJ cord-286607-5i406twr 12 33 KS KS NNP cord-286607-5i406twr 12 34 - - HYPH cord-286607-5i406twr 12 35 specific specific JJ cord-286607-5i406twr 12 36 therapies therapy NNS cord-286607-5i406twr 12 37 . . . cord-286607-5i406twr 13 1 The the DT cord-286607-5i406twr 13 2 most most RBS cord-286607-5i406twr 13 3 insidious insidious JJ cord-286607-5i406twr 13 4 primary primary JJ cord-286607-5i406twr 13 5 vasculitis vasculitis NN cord-286607-5i406twr 13 6 in in IN cord-286607-5i406twr 13 7 childhood childhood NN cord-286607-5i406twr 13 8 is be VBZ cord-286607-5i406twr 13 9 Kawasaki Kawasaki NNP cord-286607-5i406twr 13 10 syndrome syndrome NN cord-286607-5i406twr 13 11 ( ( -LRB- cord-286607-5i406twr 13 12 KS KS NNP cord-286607-5i406twr 13 13 ) ) -RRB- cord-286607-5i406twr 13 14 , , , cord-286607-5i406twr 13 15 an an DT cord-286607-5i406twr 13 16 acute acute JJ cord-286607-5i406twr 13 17 multi multi JJ cord-286607-5i406twr 13 18 - - JJ cord-286607-5i406twr 13 19 systemic systemic JJ cord-286607-5i406twr 13 20 illness illness NN cord-286607-5i406twr 13 21 which which WDT cord-286607-5i406twr 13 22 predominantly predominantly RB cord-286607-5i406twr 13 23 affects affect VBZ cord-286607-5i406twr 13 24 children child NNS cord-286607-5i406twr 13 25 under under IN cord-286607-5i406twr 13 26 5 5 CD cord-286607-5i406twr 13 27 years year NNS cord-286607-5i406twr 13 28 of of IN cord-286607-5i406twr 13 29 age age NN cord-286607-5i406twr 13 30 ( ( -LRB- cord-286607-5i406twr 13 31 1 1 CD cord-286607-5i406twr 13 32 ) ) -RRB- cord-286607-5i406twr 13 33 . . . cord-286607-5i406twr 14 1 Currently currently RB cord-286607-5i406twr 14 2 , , , cord-286607-5i406twr 14 3 this this DT cord-286607-5i406twr 14 4 disorder disorder NN cord-286607-5i406twr 14 5 of of IN cord-286607-5i406twr 14 6 unknown unknown JJ cord-286607-5i406twr 14 7 etiology etiology NN cord-286607-5i406twr 14 8 remains remain VBZ cord-286607-5i406twr 14 9 the the DT cord-286607-5i406twr 14 10 main main JJ cord-286607-5i406twr 14 11 cause cause NN cord-286607-5i406twr 14 12 of of IN cord-286607-5i406twr 14 13 acquired acquire VBN cord-286607-5i406twr 14 14 heart heart NN cord-286607-5i406twr 14 15 disease disease NN cord-286607-5i406twr 14 16 among among IN cord-286607-5i406twr 14 17 children child NNS cord-286607-5i406twr 14 18 living live VBG cord-286607-5i406twr 14 19 in in IN cord-286607-5i406twr 14 20 developed develop VBN cord-286607-5i406twr 14 21 countries country NNS cord-286607-5i406twr 14 22 , , , cord-286607-5i406twr 14 23 where where WRB cord-286607-5i406twr 14 24 rheumatic rheumatic JJ cord-286607-5i406twr 14 25 fever fever NN cord-286607-5i406twr 14 26 has have VBZ cord-286607-5i406twr 14 27 been be VBN cord-286607-5i406twr 14 28 surpassed surpass VBN cord-286607-5i406twr 14 29 ( ( -LRB- cord-286607-5i406twr 14 30 2 2 CD cord-286607-5i406twr 14 31 , , , cord-286607-5i406twr 14 32 3 3 CD cord-286607-5i406twr 14 33 ) ) -RRB- cord-286607-5i406twr 14 34 . . . cord-286607-5i406twr 15 1 This this DT cord-286607-5i406twr 15 2 condition condition NN cord-286607-5i406twr 15 3 was be VBD cord-286607-5i406twr 15 4 originally originally RB cord-286607-5i406twr 15 5 called call VBN cord-286607-5i406twr 15 6 " " `` cord-286607-5i406twr 15 7 mucocutaneous mucocutaneous JJ cord-286607-5i406twr 15 8 lymph lymph NNP cord-286607-5i406twr 15 9 node node NN cord-286607-5i406twr 15 10 syndrome syndrome NN cord-286607-5i406twr 15 11 " " '' cord-286607-5i406twr 15 12 by by IN cord-286607-5i406twr 15 13 Dr. Dr. NNP cord-286607-5i406twr 15 14 Tomisaku Tomisaku NNP cord-286607-5i406twr 15 15 Kawasaki Kawasaki NNP cord-286607-5i406twr 15 16 , , , cord-286607-5i406twr 15 17 who who WP cord-286607-5i406twr 15 18 was be VBD cord-286607-5i406twr 15 19 its -PRON- PRP$ cord-286607-5i406twr 15 20 discoverer discoverer NN cord-286607-5i406twr 15 21 , , , cord-286607-5i406twr 15 22 and and CC cord-286607-5i406twr 15 23 was be VBD cord-286607-5i406twr 15 24 thought think VBN cord-286607-5i406twr 15 25 to to TO cord-286607-5i406twr 15 26 be be VB cord-286607-5i406twr 15 27 a a DT cord-286607-5i406twr 15 28 benign benign JJ cord-286607-5i406twr 15 29 children child NNS cord-286607-5i406twr 15 30 's 's POS cord-286607-5i406twr 15 31 disease disease NN cord-286607-5i406twr 15 32 ; ; : cord-286607-5i406twr 15 33 nowadays nowadays RB cord-286607-5i406twr 15 34 , , , cord-286607-5i406twr 15 35 the the DT cord-286607-5i406twr 15 36 illness illness NN cord-286607-5i406twr 15 37 has have VBZ cord-286607-5i406twr 15 38 been be VBN cord-286607-5i406twr 15 39 described describe VBN cord-286607-5i406twr 15 40 worldwide worldwide RB cord-286607-5i406twr 15 41 in in IN cord-286607-5i406twr 15 42 children child NNS cord-286607-5i406twr 15 43 of of IN cord-286607-5i406twr 15 44 every every DT cord-286607-5i406twr 15 45 ethnicity ethnicity NN cord-286607-5i406twr 15 46 following follow VBG cord-286607-5i406twr 15 47 the the DT cord-286607-5i406twr 15 48 presence presence NN cord-286607-5i406twr 15 49 of of IN cord-286607-5i406twr 15 50 fever fever NN cord-286607-5i406twr 15 51 persisting persist VBG cord-286607-5i406twr 15 52 ( ( -LRB- cord-286607-5i406twr 15 53 at at IN cord-286607-5i406twr 15 54 least least JJS cord-286607-5i406twr 15 55 ) ) -RRB- cord-286607-5i406twr 15 56 5 5 CD cord-286607-5i406twr 15 57 days day NNS cord-286607-5i406twr 15 58 together together RB cord-286607-5i406twr 15 59 with with IN cord-286607-5i406twr 15 60 ( ( -LRB- cord-286607-5i406twr 15 61 at at IN cord-286607-5i406twr 15 62 least least JJS cord-286607-5i406twr 15 63 ) ) -RRB- cord-286607-5i406twr 15 64 4 4 CD cord-286607-5i406twr 15 65 of of IN cord-286607-5i406twr 15 66 the the DT cord-286607-5i406twr 15 67 5 5 CD cord-286607-5i406twr 15 68 following following NN cord-286607-5i406twr 15 69 signs sign NNS cord-286607-5i406twr 15 70 : : : cord-286607-5i406twr 15 71 bilateral bilateral JJ cord-286607-5i406twr 15 72 conjunctival conjunctival NN cord-286607-5i406twr 15 73 injection injection NN cord-286607-5i406twr 15 74 , , , cord-286607-5i406twr 15 75 oropharyngeal oropharyngeal JJ cord-286607-5i406twr 15 76 inflammation inflammation NN cord-286607-5i406twr 15 77 , , , cord-286607-5i406twr 15 78 abnormalities abnormality NNS cord-286607-5i406twr 15 79 of of IN cord-286607-5i406twr 15 80 hands hand NNS cord-286607-5i406twr 15 81 and and CC cord-286607-5i406twr 15 82 feet foot NNS cord-286607-5i406twr 15 83 , , , cord-286607-5i406twr 15 84 polymorphous polymorphous JJ cord-286607-5i406twr 15 85 exanthema exanthema NN cord-286607-5i406twr 15 86 , , , cord-286607-5i406twr 15 87 and and CC cord-286607-5i406twr 15 88 non non JJ cord-286607-5i406twr 15 89 - - JJ cord-286607-5i406twr 15 90 purulent purulent JJ cord-286607-5i406twr 15 91 cervical cervical JJ cord-286607-5i406twr 15 92 lymphadenopathy lymphadenopathy NN cord-286607-5i406twr 15 93 , , , cord-286607-5i406twr 15 94 usually usually RB cord-286607-5i406twr 15 95 unilateral unilateral JJ cord-286607-5i406twr 15 96 ( ( -LRB- cord-286607-5i406twr 15 97 4 4 CD cord-286607-5i406twr 15 98 ) ) -RRB- cord-286607-5i406twr 15 99 . . . cord-286607-5i406twr 16 1 Several several JJ cord-286607-5i406twr 16 2 years year NNS cord-286607-5i406twr 16 3 after after IN cord-286607-5i406twr 16 4 the the DT cord-286607-5i406twr 16 5 first first JJ cord-286607-5i406twr 16 6 description description NN cord-286607-5i406twr 16 7 , , , cord-286607-5i406twr 16 8 fatalities fatality NNS cord-286607-5i406twr 16 9 occurred occur VBD cord-286607-5i406twr 16 10 among among IN cord-286607-5i406twr 16 11 children child NNS cord-286607-5i406twr 16 12 with with IN cord-286607-5i406twr 16 13 KS KS NNP cord-286607-5i406twr 16 14 younger young JJR cord-286607-5i406twr 16 15 than than IN cord-286607-5i406twr 16 16 2 2 CD cord-286607-5i406twr 16 17 years year NNS cord-286607-5i406twr 16 18 living live VBG cord-286607-5i406twr 16 19 in in IN cord-286607-5i406twr 16 20 Japan Japan NNP cord-286607-5i406twr 16 21 , , , cord-286607-5i406twr 16 22 prompting prompt VBG cord-286607-5i406twr 16 23 clinicians clinician NNS cord-286607-5i406twr 16 24 to to TO cord-286607-5i406twr 16 25 reconsider reconsider VB cord-286607-5i406twr 16 26 KS KS NNP cord-286607-5i406twr 16 27 's 's POS cord-286607-5i406twr 16 28 long long JJ cord-286607-5i406twr 16 29 - - HYPH cord-286607-5i406twr 16 30 term term NN cord-286607-5i406twr 16 31 risks risk NNS cord-286607-5i406twr 16 32 related relate VBN cord-286607-5i406twr 16 33 to to IN cord-286607-5i406twr 16 34 systemic systemic JJ cord-286607-5i406twr 16 35 and and CC cord-286607-5i406twr 16 36 necrotizing necrotize VBG cord-286607-5i406twr 16 37 effects effect NNS cord-286607-5i406twr 16 38 on on IN cord-286607-5i406twr 16 39 the the DT cord-286607-5i406twr 16 40 vascular vascular JJ cord-286607-5i406twr 16 41 endothelium endothelium NN cord-286607-5i406twr 16 42 of of IN cord-286607-5i406twr 16 43 small small JJ cord-286607-5i406twr 16 44 - - HYPH cord-286607-5i406twr 16 45 and and CC cord-286607-5i406twr 16 46 medium medium JJ cord-286607-5i406twr 16 47 - - HYPH cord-286607-5i406twr 16 48 sized sized JJ cord-286607-5i406twr 16 49 arteries artery NNS cord-286607-5i406twr 16 50 , , , cord-286607-5i406twr 16 51 which which WDT cord-286607-5i406twr 16 52 have have VBP cord-286607-5i406twr 16 53 been be VBN cord-286607-5i406twr 16 54 acknowledged acknowledge VBN cord-286607-5i406twr 16 55 in in IN cord-286607-5i406twr 16 56 all all DT cord-286607-5i406twr 16 57 guidelines guideline NNS cord-286607-5i406twr 16 58 related relate VBN cord-286607-5i406twr 16 59 to to IN cord-286607-5i406twr 16 60 the the DT cord-286607-5i406twr 16 61 management management NN cord-286607-5i406twr 16 62 of of IN cord-286607-5i406twr 16 63 KS KS NNP cord-286607-5i406twr 16 64 ( ( -LRB- cord-286607-5i406twr 16 65 5 5 CD cord-286607-5i406twr 16 66 , , , cord-286607-5i406twr 16 67 6 6 CD cord-286607-5i406twr 16 68 ) ) -RRB- cord-286607-5i406twr 16 69 . . . cord-286607-5i406twr 17 1 The the DT cord-286607-5i406twr 17 2 most most RBS cord-286607-5i406twr 17 3 relevant relevant JJ cord-286607-5i406twr 17 4 sequelae sequela NNS cord-286607-5i406twr 17 5 of of IN cord-286607-5i406twr 17 6 KS KS NNP cord-286607-5i406twr 17 7 include include VBP cord-286607-5i406twr 17 8 variable variable JJ cord-286607-5i406twr 17 9 degrees degree NNS cord-286607-5i406twr 17 10 of of IN cord-286607-5i406twr 17 11 damage damage NN cord-286607-5i406twr 17 12 within within IN cord-286607-5i406twr 17 13 coronary coronary JJ cord-286607-5i406twr 17 14 arteries artery NNS cord-286607-5i406twr 17 15 in in IN cord-286607-5i406twr 17 16 combination combination NN cord-286607-5i406twr 17 17 with with IN cord-286607-5i406twr 17 18 angina angina NN cord-286607-5i406twr 17 19 , , , cord-286607-5i406twr 17 20 myocardial myocardial JJ cord-286607-5i406twr 17 21 infarction infarction NN cord-286607-5i406twr 17 22 , , , cord-286607-5i406twr 17 23 ischemic ischemic JJ cord-286607-5i406twr 17 24 cardiomyopathy cardiomyopathy NN cord-286607-5i406twr 17 25 , , , cord-286607-5i406twr 17 26 and and CC cord-286607-5i406twr 17 27 sudden sudden JJ cord-286607-5i406twr 17 28 death death NN cord-286607-5i406twr 17 29 ; ; : cord-286607-5i406twr 17 30 these these DT cord-286607-5i406twr 17 31 complications complication NNS cord-286607-5i406twr 17 32 should should MD cord-286607-5i406twr 17 33 be be VB cord-286607-5i406twr 17 34 preventable preventable JJ cord-286607-5i406twr 17 35 with with IN cord-286607-5i406twr 17 36 a a DT cord-286607-5i406twr 17 37 timely timely JJ cord-286607-5i406twr 17 38 treatment treatment NN cord-286607-5i406twr 17 39 of of IN cord-286607-5i406twr 17 40 high high JJ cord-286607-5i406twr 17 41 - - HYPH cord-286607-5i406twr 17 42 dose dose NN cord-286607-5i406twr 17 43 intravenous intravenous JJ cord-286607-5i406twr 17 44 immunoglobulin immunoglobulin NN cord-286607-5i406twr 17 45 ( ( -LRB- cord-286607-5i406twr 17 46 IVIG IVIG NNP cord-286607-5i406twr 17 47 ) ) -RRB- cord-286607-5i406twr 17 48 , , , cord-286607-5i406twr 17 49 which which WDT cord-286607-5i406twr 17 50 is be VBZ cord-286607-5i406twr 17 51 the the DT cord-286607-5i406twr 17 52 recommended recommend VBN cord-286607-5i406twr 17 53 therapeutic therapeutic JJ cord-286607-5i406twr 17 54 strategy strategy NN cord-286607-5i406twr 17 55 in in IN cord-286607-5i406twr 17 56 KS KS NNP cord-286607-5i406twr 17 57 ( ( -LRB- cord-286607-5i406twr 17 58 7 7 CD cord-286607-5i406twr 17 59 ) ) -RRB- cord-286607-5i406twr 17 60 . . . cord-286607-5i406twr 18 1 Higher high JJR cord-286607-5i406twr 18 2 acute acute JJ cord-286607-5i406twr 18 3 phase phase NN cord-286607-5i406twr 18 4 reactants reactant NNS cord-286607-5i406twr 18 5 and and CC cord-286607-5i406twr 18 6 younger young JJR cord-286607-5i406twr 18 7 age age NN cord-286607-5i406twr 18 8 at at IN cord-286607-5i406twr 18 9 onset onset NN cord-286607-5i406twr 18 10 of of IN cord-286607-5i406twr 18 11 KS KS NNP cord-286607-5i406twr 18 12 are be VBP cord-286607-5i406twr 18 13 nodal nodal JJ cord-286607-5i406twr 18 14 points point NNS cord-286607-5i406twr 18 15 in in IN cord-286607-5i406twr 18 16 determining determine VBG cord-286607-5i406twr 18 17 , , , cord-286607-5i406twr 18 18 respectively respectively RB cord-286607-5i406twr 18 19 , , , cord-286607-5i406twr 18 20 a a DT cord-286607-5i406twr 18 21 failure failure NN cord-286607-5i406twr 18 22 in in IN cord-286607-5i406twr 18 23 the the DT cord-286607-5i406twr 18 24 response response NN cord-286607-5i406twr 18 25 to to IN cord-286607-5i406twr 18 26 IVIG IVIG NNP cord-286607-5i406twr 18 27 and and CC cord-286607-5i406twr 18 28 an an DT cord-286607-5i406twr 18 29 increased increase VBN cord-286607-5i406twr 18 30 occurrence occurrence NN cord-286607-5i406twr 18 31 of of IN cord-286607-5i406twr 18 32 coronary coronary JJ cord-286607-5i406twr 18 33 artery artery NN cord-286607-5i406twr 18 34 abnormalities abnormality NNS cord-286607-5i406twr 18 35 ( ( -LRB- cord-286607-5i406twr 18 36 8) 8) NNP cord-286607-5i406twr 18 37 . . . cord-286607-5i406twr 19 1 The the DT cord-286607-5i406twr 19 2 prediction prediction NN cord-286607-5i406twr 19 3 of of IN cord-286607-5i406twr 19 4 IVIG IVIG NNP cord-286607-5i406twr 19 5 resistance resistance NN cord-286607-5i406twr 19 6 is be VBZ cord-286607-5i406twr 19 7 also also RB cord-286607-5i406twr 19 8 crucial crucial JJ cord-286607-5i406twr 19 9 in in IN cord-286607-5i406twr 19 10 KS KS NNP cord-286607-5i406twr 19 11 patients patient NNS cord-286607-5i406twr 19 12 , , , cord-286607-5i406twr 19 13 as as IN cord-286607-5i406twr 19 14 recognizing recognize VBG cord-286607-5i406twr 19 15 these these DT cord-286607-5i406twr 19 16 high high JJ cord-286607-5i406twr 19 17 - - HYPH cord-286607-5i406twr 19 18 risk risk NN cord-286607-5i406twr 19 19 children child NNS cord-286607-5i406twr 19 20 should should MD cord-286607-5i406twr 19 21 consent consent VB cord-286607-5i406twr 19 22 to to TO cord-286607-5i406twr 19 23 start start VB cord-286607-5i406twr 19 24 an an DT cord-286607-5i406twr 19 25 intensified intensify VBN cord-286607-5i406twr 19 26 treatment treatment NN cord-286607-5i406twr 19 27 protocol protocol NN cord-286607-5i406twr 19 28 combined combine VBN cord-286607-5i406twr 19 29 with with IN cord-286607-5i406twr 19 30 IVIG IVIG NNP cord-286607-5i406twr 19 31 to to TO cord-286607-5i406twr 19 32 prevent prevent VB cord-286607-5i406twr 19 33 coronary coronary JJ cord-286607-5i406twr 19 34 injuries injury NNS cord-286607-5i406twr 19 35 ( ( -LRB- cord-286607-5i406twr 19 36 9 9 CD cord-286607-5i406twr 19 37 ) ) -RRB- cord-286607-5i406twr 19 38 . . . cord-286607-5i406twr 20 1 KS KS NNP cord-286607-5i406twr 20 2 incidence incidence NN cord-286607-5i406twr 20 3 varies vary VBZ cord-286607-5i406twr 20 4 widely widely RB cord-286607-5i406twr 20 5 among among IN cord-286607-5i406twr 20 6 different different JJ cord-286607-5i406twr 20 7 ethnic ethnic JJ cord-286607-5i406twr 20 8 groups group NNS cord-286607-5i406twr 20 9 ; ; : cord-286607-5i406twr 20 10 for for IN cord-286607-5i406twr 20 11 instance instance NN cord-286607-5i406twr 20 12 , , , cord-286607-5i406twr 20 13 in in IN cord-286607-5i406twr 20 14 the the DT cord-286607-5i406twr 20 15 United United NNP cord-286607-5i406twr 20 16 Kingdom Kingdom NNP cord-286607-5i406twr 20 17 it -PRON- PRP cord-286607-5i406twr 20 18 has have VBZ cord-286607-5i406twr 20 19 stabilized stabilize VBN cord-286607-5i406twr 20 20 and and CC cord-286607-5i406twr 20 21 remains remain VBZ cord-286607-5i406twr 20 22 low low JJ cord-286607-5i406twr 20 23 at at IN cord-286607-5i406twr 20 24 2.8 2.8 CD cord-286607-5i406twr 20 25 per per IN cord-286607-5i406twr 20 26 100,000 100,000 CD cord-286607-5i406twr 20 27 population population NN cord-286607-5i406twr 20 28 under under IN cord-286607-5i406twr 20 29 the the DT cord-286607-5i406twr 20 30 age age NN cord-286607-5i406twr 20 31 of of IN cord-286607-5i406twr 20 32 20 20 CD cord-286607-5i406twr 20 33 years year NNS cord-286607-5i406twr 20 34 . . . cord-286607-5i406twr 21 1 However however RB cord-286607-5i406twr 21 2 , , , cord-286607-5i406twr 21 3 general general JJ cord-286607-5i406twr 21 4 practitioners practitioner NNS cord-286607-5i406twr 21 5 should should MD cord-286607-5i406twr 21 6 be be VB cord-286607-5i406twr 21 7 aware aware JJ cord-286607-5i406twr 21 8 that that IN cord-286607-5i406twr 21 9 the the DT cord-286607-5i406twr 21 10 condition condition NN cord-286607-5i406twr 21 11 occurs occur VBZ cord-286607-5i406twr 21 12 throughout throughout IN cord-286607-5i406twr 21 13 childhood childhood NN cord-286607-5i406twr 21 14 and and CC cord-286607-5i406twr 21 15 across across IN cord-286607-5i406twr 21 16 the the DT cord-286607-5i406twr 21 17 seasons season NNS cord-286607-5i406twr 21 18 , , , cord-286607-5i406twr 21 19 and and CC cord-286607-5i406twr 21 20 - - HYPH cord-286607-5i406twr 21 21 given give VBN cord-286607-5i406twr 21 22 the the DT cord-286607-5i406twr 21 23 potential potential JJ cord-286607-5i406twr 21 24 cardiovascular cardiovascular JJ cord-286607-5i406twr 21 25 sequelae sequela NNS cord-286607-5i406twr 21 26 - - : cord-286607-5i406twr 21 27 KS KS NNP cord-286607-5i406twr 21 28 should should MD cord-286607-5i406twr 21 29 be be VB cord-286607-5i406twr 21 30 considered consider VBN cord-286607-5i406twr 21 31 in in IN cord-286607-5i406twr 21 32 all all DT cord-286607-5i406twr 21 33 children child NNS cord-286607-5i406twr 21 34 with with IN cord-286607-5i406twr 21 35 persistent persistent JJ cord-286607-5i406twr 21 36 fever fever NN cord-286607-5i406twr 21 37 , , , cord-286607-5i406twr 21 38 even even RB cord-286607-5i406twr 21 39 in in IN cord-286607-5i406twr 21 40 older old JJR cord-286607-5i406twr 21 41 children child NNS cord-286607-5i406twr 21 42 and and CC cord-286607-5i406twr 21 43 adolescents adolescent NNS cord-286607-5i406twr 21 44 ( ( -LRB- cord-286607-5i406twr 21 45 10 10 CD cord-286607-5i406twr 21 46 ) ) -RRB- cord-286607-5i406twr 21 47 . . . cord-286607-5i406twr 22 1 KS KS NNP cord-286607-5i406twr 22 2 is be VBZ cord-286607-5i406twr 22 3 most most RBS cord-286607-5i406twr 22 4 prominently prominently RB cord-286607-5i406twr 22 5 recognized recognize VBN cord-286607-5i406twr 22 6 in in IN cord-286607-5i406twr 22 7 Japan Japan NNP cord-286607-5i406twr 22 8 , , , cord-286607-5i406twr 22 9 Korea Korea NNP cord-286607-5i406twr 22 10 , , , cord-286607-5i406twr 22 11 and and CC cord-286607-5i406twr 22 12 Taiwan Taiwan NNP cord-286607-5i406twr 22 13 , , , cord-286607-5i406twr 22 14 reflecting reflect VBG cord-286607-5i406twr 22 15 increased increase VBN cord-286607-5i406twr 22 16 genetic genetic JJ cord-286607-5i406twr 22 17 susceptibility susceptibility NN cord-286607-5i406twr 22 18 among among IN cord-286607-5i406twr 22 19 Asian asian JJ cord-286607-5i406twr 22 20 populations population NNS cord-286607-5i406twr 22 21 . . . cord-286607-5i406twr 23 1 A a DT cord-286607-5i406twr 23 2 recent recent JJ cord-286607-5i406twr 23 3 study study NN cord-286607-5i406twr 23 4 reported report VBD cord-286607-5i406twr 23 5 an an DT cord-286607-5i406twr 23 6 incidence incidence NN cord-286607-5i406twr 23 7 of of IN cord-286607-5i406twr 23 8 ∼240 ∼240 NNP cord-286607-5i406twr 23 9 per per IN cord-286607-5i406twr 23 10 100,000 100,000 CD cord-286607-5i406twr 23 11 children child NNS cord-286607-5i406twr 23 12 under under IN cord-286607-5i406twr 23 13 4 4 CD cord-286607-5i406twr 23 14 years year NNS cord-286607-5i406twr 23 15 of of IN cord-286607-5i406twr 23 16 age age NN cord-286607-5i406twr 23 17 in in IN cord-286607-5i406twr 23 18 Japan Japan NNP cord-286607-5i406twr 23 19 ( ( -LRB- cord-286607-5i406twr 23 20 11 11 CD cord-286607-5i406twr 23 21 ) ) -RRB- cord-286607-5i406twr 23 22 . . . cord-286607-5i406twr 24 1 There there EX cord-286607-5i406twr 24 2 is be VBZ cord-286607-5i406twr 24 3 still still RB cord-286607-5i406twr 24 4 much much JJ cord-286607-5i406twr 24 5 controversy controversy NN cord-286607-5i406twr 24 6 about about IN cord-286607-5i406twr 24 7 the the DT cord-286607-5i406twr 24 8 etiology etiology NN cord-286607-5i406twr 24 9 of of IN cord-286607-5i406twr 24 10 KS KS NNP cord-286607-5i406twr 24 11 , , , cord-286607-5i406twr 24 12 though though IN cord-286607-5i406twr 24 13 epidemiologic epidemiologic JJ cord-286607-5i406twr 24 14 and and CC cord-286607-5i406twr 24 15 clinical clinical JJ cord-286607-5i406twr 24 16 data datum NNS cord-286607-5i406twr 24 17 suggest suggest VBP cord-286607-5i406twr 24 18 that that IN cord-286607-5i406twr 24 19 KS KS NNP cord-286607-5i406twr 24 20 might may MD cord-286607-5i406twr 24 21 originate originate VB cord-286607-5i406twr 24 22 from from IN cord-286607-5i406twr 24 23 an an DT cord-286607-5i406twr 24 24 abnormal abnormal JJ cord-286607-5i406twr 24 25 response response NN cord-286607-5i406twr 24 26 to to IN cord-286607-5i406twr 24 27 undisclosed undisclosed JJ cord-286607-5i406twr 24 28 infectious infectious JJ cord-286607-5i406twr 24 29 diseases disease NNS cord-286607-5i406twr 24 30 in in IN cord-286607-5i406twr 24 31 genetically genetically RB cord-286607-5i406twr 24 32 susceptible susceptible JJ cord-286607-5i406twr 24 33 children child NNS cord-286607-5i406twr 24 34 ( ( -LRB- cord-286607-5i406twr 24 35 12 12 CD cord-286607-5i406twr 24 36 ) ) -RRB- cord-286607-5i406twr 24 37 . . . cord-286607-5i406twr 25 1 There there EX cord-286607-5i406twr 25 2 is be VBZ cord-286607-5i406twr 25 3 no no DT cord-286607-5i406twr 25 4 agreement agreement NN cord-286607-5i406twr 25 5 whether whether IN cord-286607-5i406twr 25 6 KS KS NNP cord-286607-5i406twr 25 7 - - HYPH cord-286607-5i406twr 25 8 related relate VBN cord-286607-5i406twr 25 9 infectious infectious JJ cord-286607-5i406twr 25 10 agents agent NNS cord-286607-5i406twr 25 11 are be VBP cord-286607-5i406twr 25 12 of of IN cord-286607-5i406twr 25 13 viral viral JJ cord-286607-5i406twr 25 14 , , , cord-286607-5i406twr 25 15 bacterial bacterial JJ cord-286607-5i406twr 25 16 or or CC cord-286607-5i406twr 25 17 fungal fungal JJ cord-286607-5i406twr 25 18 origin origin NN cord-286607-5i406twr 25 19 ( ( -LRB- cord-286607-5i406twr 25 20 13 13 CD cord-286607-5i406twr 25 21 ) ) -RRB- cord-286607-5i406twr 25 22 , , , cord-286607-5i406twr 25 23 and and CC cord-286607-5i406twr 25 24 the the DT cord-286607-5i406twr 25 25 underlying underlying JJ cord-286607-5i406twr 25 26 immune immune JJ cord-286607-5i406twr 25 27 mechanisms mechanism NNS cord-286607-5i406twr 25 28 behind behind IN cord-286607-5i406twr 25 29 KS KS NNP cord-286607-5i406twr 25 30 have have VBP cord-286607-5i406twr 25 31 not not RB cord-286607-5i406twr 25 32 been be VBN cord-286607-5i406twr 25 33 completely completely RB cord-286607-5i406twr 25 34 highlighted highlight VBN cord-286607-5i406twr 25 35 , , , cord-286607-5i406twr 25 36 remaining remain VBG cord-286607-5i406twr 25 37 only only RB cord-286607-5i406twr 25 38 partially partially RB cord-286607-5i406twr 25 39 known know VBN cord-286607-5i406twr 25 40 . . . cord-286607-5i406twr 26 1 The the DT cord-286607-5i406twr 26 2 absence absence NN cord-286607-5i406twr 26 3 of of IN cord-286607-5i406twr 26 4 a a DT cord-286607-5i406twr 26 5 proven prove VBN cord-286607-5i406twr 26 6 unambiguous unambiguous JJ cord-286607-5i406twr 26 7 cause cause NN cord-286607-5i406twr 26 8 of of IN cord-286607-5i406twr 26 9 KS KS NNP cord-286607-5i406twr 26 10 has have VBZ cord-286607-5i406twr 26 11 induced induce VBN cord-286607-5i406twr 26 12 the the DT cord-286607-5i406twr 26 13 scientific scientific JJ cord-286607-5i406twr 26 14 community community NN cord-286607-5i406twr 26 15 to to TO cord-286607-5i406twr 26 16 pay pay VB cord-286607-5i406twr 26 17 attention attention NN cord-286607-5i406twr 26 18 to to IN cord-286607-5i406twr 26 19 other other JJ cord-286607-5i406twr 26 20 environmental environmental JJ cord-286607-5i406twr 26 21 hypothetical hypothetical JJ cord-286607-5i406twr 26 22 triggers trigger NNS cord-286607-5i406twr 26 23 , , , cord-286607-5i406twr 26 24 and and CC cord-286607-5i406twr 26 25 in in IN cord-286607-5i406twr 26 26 particular particular JJ cord-286607-5i406twr 26 27 the the DT cord-286607-5i406twr 26 28 composition composition NN cord-286607-5i406twr 26 29 of of IN cord-286607-5i406twr 26 30 the the DT cord-286607-5i406twr 26 31 resident resident JJ cord-286607-5i406twr 26 32 intestinal intestinal JJ cord-286607-5i406twr 26 33 flora flora NNS cord-286607-5i406twr 26 34 as as IN cord-286607-5i406twr 26 35 a a DT cord-286607-5i406twr 26 36 potential potential JJ cord-286607-5i406twr 26 37 contributor contributor NN cord-286607-5i406twr 26 38 to to IN cord-286607-5i406twr 26 39 KS KS NNP cord-286607-5i406twr 26 40 has have VBZ cord-286607-5i406twr 26 41 been be VBN cord-286607-5i406twr 26 42 evaluated evaluate VBN cord-286607-5i406twr 26 43 by by IN cord-286607-5i406twr 26 44 different different JJ cord-286607-5i406twr 26 45 research research NN cord-286607-5i406twr 26 46 groups group NNS cord-286607-5i406twr 26 47 . . . cord-286607-5i406twr 27 1 The the DT cord-286607-5i406twr 27 2 main main JJ cord-286607-5i406twr 27 3 aim aim NN cord-286607-5i406twr 27 4 of of IN cord-286607-5i406twr 27 5 this this DT cord-286607-5i406twr 27 6 review review NN cord-286607-5i406twr 27 7 was be VBD cord-286607-5i406twr 27 8 to to TO cord-286607-5i406twr 27 9 analyze analyze VB cord-286607-5i406twr 27 10 the the DT cord-286607-5i406twr 27 11 relationship relationship NN cord-286607-5i406twr 27 12 between between IN cord-286607-5i406twr 27 13 the the DT cord-286607-5i406twr 27 14 microbial microbial JJ cord-286607-5i406twr 27 15 community community NN cord-286607-5i406twr 27 16 , , , cord-286607-5i406twr 27 17 or or CC cord-286607-5i406twr 27 18 the the DT cord-286607-5i406twr 27 19 " " `` cord-286607-5i406twr 27 20 microbiota microbiota NN cord-286607-5i406twr 27 21 , , , cord-286607-5i406twr 27 22 " " '' cord-286607-5i406twr 27 23 and and CC cord-286607-5i406twr 27 24 the the DT cord-286607-5i406twr 27 25 overall overall JJ cord-286607-5i406twr 27 26 impact impact NN cord-286607-5i406twr 27 27 of of IN cord-286607-5i406twr 27 28 bacterial bacterial JJ cord-286607-5i406twr 27 29 or or CC cord-286607-5i406twr 27 30 viral viral JJ cord-286607-5i406twr 27 31 infections infection NNS cord-286607-5i406twr 27 32 in in IN cord-286607-5i406twr 27 33 the the DT cord-286607-5i406twr 27 34 potential potential JJ cord-286607-5i406twr 27 35 development development NN cord-286607-5i406twr 27 36 of of IN cord-286607-5i406twr 27 37 KS KS NNP cord-286607-5i406twr 27 38 . . . cord-286607-5i406twr 28 1 Scientific scientific JJ cord-286607-5i406twr 28 2 papers paper NNS cord-286607-5i406twr 28 3 have have VBP cord-286607-5i406twr 28 4 been be VBN cord-286607-5i406twr 28 5 searched search VBN cord-286607-5i406twr 28 6 from from IN cord-286607-5i406twr 28 7 the the DT cord-286607-5i406twr 28 8 electronic electronic JJ cord-286607-5i406twr 28 9 databases database NNS cord-286607-5i406twr 28 10 of of IN cord-286607-5i406twr 28 11 PubMed PubMed NNP cord-286607-5i406twr 28 12 until until IN cord-286607-5i406twr 28 13 January January NNP cord-286607-5i406twr 28 14 2019 2019 CD cord-286607-5i406twr 28 15 ; ; : cord-286607-5i406twr 28 16 the the DT cord-286607-5i406twr 28 17 retrieving retrieve VBG cord-286607-5i406twr 28 18 words word NNS cord-286607-5i406twr 28 19 were be VBD cord-286607-5i406twr 28 20 " " `` cord-286607-5i406twr 28 21 Kawasaki Kawasaki NNP cord-286607-5i406twr 28 22 disease disease NN cord-286607-5i406twr 28 23 , , , cord-286607-5i406twr 28 24 " " '' cord-286607-5i406twr 28 25 " " `` cord-286607-5i406twr 28 26 Kawasaki Kawasaki NNP cord-286607-5i406twr 28 27 syndrome syndrome NN cord-286607-5i406twr 28 28 , , , cord-286607-5i406twr 28 29 " " '' cord-286607-5i406twr 28 30 " " `` cord-286607-5i406twr 28 31 microbiota microbiota NN cord-286607-5i406twr 28 32 , , , cord-286607-5i406twr 28 33 " " '' cord-286607-5i406twr 28 34 and and CC cord-286607-5i406twr 28 35 " " `` cord-286607-5i406twr 28 36 microbiome microbiome NN cord-286607-5i406twr 28 37 " " '' cord-286607-5i406twr 28 38 ; ; , cord-286607-5i406twr 28 39 additional additional JJ cord-286607-5i406twr 28 40 reports report NNS cord-286607-5i406twr 28 41 were be VBD cord-286607-5i406twr 28 42 identified identify VBN cord-286607-5i406twr 28 43 and and CC cord-286607-5i406twr 28 44 analyzed analyze VBN cord-286607-5i406twr 28 45 through through IN cord-286607-5i406twr 28 46 the the DT cord-286607-5i406twr 28 47 specific specific JJ cord-286607-5i406twr 28 48 references reference NNS cord-286607-5i406twr 28 49 cited cite VBN cord-286607-5i406twr 28 50 in in IN cord-286607-5i406twr 28 51 the the DT cord-286607-5i406twr 28 52 retrieved retrieve VBN cord-286607-5i406twr 28 53 papers paper NNS cord-286607-5i406twr 28 54 . . . cord-286607-5i406twr 29 1 Only only JJ cord-286607-5i406twr 29 2 papers paper NNS cord-286607-5i406twr 29 3 published publish VBN cord-286607-5i406twr 29 4 in in IN cord-286607-5i406twr 29 5 English English NNP cord-286607-5i406twr 29 6 and and CC cord-286607-5i406twr 29 7 those those DT cord-286607-5i406twr 29 8 showing show VBG cord-286607-5i406twr 29 9 evidence evidence NN cord-286607-5i406twr 29 10 - - HYPH cord-286607-5i406twr 29 11 based base VBN cord-286607-5i406twr 29 12 data datum NNS cord-286607-5i406twr 29 13 were be VBD cord-286607-5i406twr 29 14 included include VBN cord-286607-5i406twr 29 15 in in IN cord-286607-5i406twr 29 16 our -PRON- PRP$ cord-286607-5i406twr 29 17 evaluation evaluation NN cord-286607-5i406twr 29 18 . . . cord-286607-5i406twr 30 1 The the DT cord-286607-5i406twr 30 2 microbiota microbiota NN cord-286607-5i406twr 30 3 , , , cord-286607-5i406twr 30 4 a a DT cord-286607-5i406twr 30 5 microbial microbial JJ cord-286607-5i406twr 30 6 community community NN cord-286607-5i406twr 30 7 of of IN cord-286607-5i406twr 30 8 trillions trillion NNS cord-286607-5i406twr 30 9 of of IN cord-286607-5i406twr 30 10 microorganisms microorganism NNS cord-286607-5i406twr 30 11 and and CC cord-286607-5i406twr 30 12 at at RB cord-286607-5i406twr 30 13 least least JJS cord-286607-5i406twr 30 14 1,000 1,000 CD cord-286607-5i406twr 30 15 different different JJ cord-286607-5i406twr 30 16 bacterial bacterial JJ cord-286607-5i406twr 30 17 species specie NNS cord-286607-5i406twr 30 18 , , , cord-286607-5i406twr 30 19 some some DT cord-286607-5i406twr 30 20 eukaryotic eukaryotic JJ cord-286607-5i406twr 30 21 fungi fungus NNS cord-286607-5i406twr 30 22 and and CC cord-286607-5i406twr 30 23 viruses virus NNS cord-286607-5i406twr 30 24 , , , cord-286607-5i406twr 30 25 and and CC cord-286607-5i406twr 30 26 which which WDT cord-286607-5i406twr 30 27 covers cover VBZ cord-286607-5i406twr 30 28 every every DT cord-286607-5i406twr 30 29 surface surface NN cord-286607-5i406twr 30 30 of of IN cord-286607-5i406twr 30 31 the the DT cord-286607-5i406twr 30 32 human human JJ cord-286607-5i406twr 30 33 body body NN cord-286607-5i406twr 30 34 , , , cord-286607-5i406twr 30 35 plays play VBZ cord-286607-5i406twr 30 36 a a DT cord-286607-5i406twr 30 37 contributory contributory JJ cord-286607-5i406twr 30 38 role role NN cord-286607-5i406twr 30 39 in in IN cord-286607-5i406twr 30 40 many many JJ cord-286607-5i406twr 30 41 infections infection NNS cord-286607-5i406twr 30 42 , , , cord-286607-5i406twr 30 43 immune immune NN cord-286607-5i406twr 30 44 - - HYPH cord-286607-5i406twr 30 45 mediated mediate VBN cord-286607-5i406twr 30 46 disorders disorder NNS cord-286607-5i406twr 30 47 , , , cord-286607-5i406twr 30 48 rheumatologic rheumatologic JJ cord-286607-5i406twr 30 49 diseases disease NNS cord-286607-5i406twr 30 50 , , , cord-286607-5i406twr 30 51 and and CC cord-286607-5i406twr 30 52 disorders disorder NNS cord-286607-5i406twr 30 53 of of IN cord-286607-5i406twr 30 54 the the DT cord-286607-5i406twr 30 55 nervous nervous JJ cord-286607-5i406twr 30 56 system system NN cord-286607-5i406twr 30 57 . . . cord-286607-5i406twr 31 1 The the DT cord-286607-5i406twr 31 2 microbiome microbiome NN cord-286607-5i406twr 31 3 , , , cord-286607-5i406twr 31 4 on on IN cord-286607-5i406twr 31 5 the the DT cord-286607-5i406twr 31 6 other other JJ cord-286607-5i406twr 31 7 hand hand NN cord-286607-5i406twr 31 8 , , , cord-286607-5i406twr 31 9 is be VBZ cord-286607-5i406twr 31 10 the the DT cord-286607-5i406twr 31 11 collection collection NN cord-286607-5i406twr 31 12 of of IN cord-286607-5i406twr 31 13 the the DT cord-286607-5i406twr 31 14 whole whole JJ cord-286607-5i406twr 31 15 genome genome NN cord-286607-5i406twr 31 16 sequences sequence NNS cord-286607-5i406twr 31 17 of of IN cord-286607-5i406twr 31 18 those those DT cord-286607-5i406twr 31 19 microorganisms microorganism NNS cord-286607-5i406twr 31 20 , , , cord-286607-5i406twr 31 21 consisting consist VBG cord-286607-5i406twr 31 22 of of IN cord-286607-5i406twr 31 23 more more JJR cord-286607-5i406twr 31 24 than than IN cord-286607-5i406twr 31 25 5,000,000 5,000,000 CD cord-286607-5i406twr 31 26 genes gene NNS cord-286607-5i406twr 31 27 ( ( -LRB- cord-286607-5i406twr 31 28 14 14 CD cord-286607-5i406twr 31 29 , , , cord-286607-5i406twr 31 30 15 15 CD cord-286607-5i406twr 31 31 ) ) -RRB- cord-286607-5i406twr 31 32 . . . cord-286607-5i406twr 32 1 In in IN cord-286607-5i406twr 32 2 particular particular JJ cord-286607-5i406twr 32 3 , , , cord-286607-5i406twr 32 4 the the DT cord-286607-5i406twr 32 5 gut gut NN cord-286607-5i406twr 32 6 microbiota microbiota NN cord-286607-5i406twr 32 7 is be VBZ cord-286607-5i406twr 32 8 strictly strictly RB cord-286607-5i406twr 32 9 linked link VBN cord-286607-5i406twr 32 10 to to IN cord-286607-5i406twr 32 11 the the DT cord-286607-5i406twr 32 12 chronological chronological JJ cord-286607-5i406twr 32 13 age age NN cord-286607-5i406twr 32 14 of of IN cord-286607-5i406twr 32 15 each each DT cord-286607-5i406twr 32 16 individual individual NN cord-286607-5i406twr 32 17 and and CC cord-286607-5i406twr 32 18 modulates modulate VBZ cord-286607-5i406twr 32 19 host host NN cord-286607-5i406twr 32 20 physiology physiology NN cord-286607-5i406twr 32 21 and and CC cord-286607-5i406twr 32 22 metabolism metabolism NN cord-286607-5i406twr 32 23 through through IN cord-286607-5i406twr 32 24 different different JJ cord-286607-5i406twr 32 25 mechanisms mechanism NNS cord-286607-5i406twr 32 26 . . . cord-286607-5i406twr 33 1 Each each DT cord-286607-5i406twr 33 2 stage stage NN cord-286607-5i406twr 33 3 of of IN cord-286607-5i406twr 33 4 human human JJ cord-286607-5i406twr 33 5 life life NN cord-286607-5i406twr 33 6 is be VBZ cord-286607-5i406twr 33 7 characterized characterize VBN cord-286607-5i406twr 33 8 by by IN cord-286607-5i406twr 33 9 a a DT cord-286607-5i406twr 33 10 specific specific JJ cord-286607-5i406twr 33 11 intestinal intestinal JJ cord-286607-5i406twr 33 12 microbial microbial JJ cord-286607-5i406twr 33 13 composition composition NN cord-286607-5i406twr 33 14 : : : cord-286607-5i406twr 33 15 the the DT cord-286607-5i406twr 33 16 microbiota microbiota NN cord-286607-5i406twr 33 17 that that WDT cord-286607-5i406twr 33 18 initially initially RB cord-286607-5i406twr 33 19 colonizes colonize VBZ cord-286607-5i406twr 33 20 the the DT cord-286607-5i406twr 33 21 fetus fetus NN cord-286607-5i406twr 33 22 ' ' `` cord-286607-5i406twr 33 23 intestinal intestinal JJ cord-286607-5i406twr 33 24 tube tube NN cord-286607-5i406twr 33 25 consists consist NNS cord-286607-5i406twr 33 26 of of IN cord-286607-5i406twr 33 27 aerobic aerobic JJ cord-286607-5i406twr 33 28 organisms organism NNS cord-286607-5i406twr 33 29 such such JJ cord-286607-5i406twr 33 30 as as IN cord-286607-5i406twr 33 31 Enterococcus Enterococcus NNP cord-286607-5i406twr 33 32 and and CC cord-286607-5i406twr 33 33 Streptococcus Streptococcus NNP cord-286607-5i406twr 33 34 , , , cord-286607-5i406twr 33 35 is be VBZ cord-286607-5i406twr 33 36 then then RB cord-286607-5i406twr 33 37 gradually gradually RB cord-286607-5i406twr 33 38 replaced replace VBN cord-286607-5i406twr 33 39 by by IN cord-286607-5i406twr 33 40 anaerobes anaerobe NNS cord-286607-5i406twr 33 41 such such JJ cord-286607-5i406twr 33 42 as as IN cord-286607-5i406twr 33 43 Bifidobacterium bifidobacterium NN cord-286607-5i406twr 33 44 and and CC cord-286607-5i406twr 33 45 Lactobacillus Lactobacillus NNP cord-286607-5i406twr 33 46 and and CC cord-286607-5i406twr 33 47 finally finally RB cord-286607-5i406twr 33 48 reaches reach VBZ cord-286607-5i406twr 33 49 the the DT cord-286607-5i406twr 33 50 adult adult NN cord-286607-5i406twr 33 51 composition composition NN cord-286607-5i406twr 33 52 dominated dominate VBN cord-286607-5i406twr 33 53 by by IN cord-286607-5i406twr 33 54 Bacteroides Bacteroides NNP cord-286607-5i406twr 33 55 and and CC cord-286607-5i406twr 33 56 Firmicutes Firmicutes NNPS cord-286607-5i406twr 33 57 ( ( -LRB- cord-286607-5i406twr 33 58 16 16 CD cord-286607-5i406twr 33 59 , , , cord-286607-5i406twr 33 60 17 17 CD cord-286607-5i406twr 33 61 ) ) -RRB- cord-286607-5i406twr 33 62 . . . cord-286607-5i406twr 34 1 The the DT cord-286607-5i406twr 34 2 fetal fetal JJ cord-286607-5i406twr 34 3 microbiota microbiota NN cord-286607-5i406twr 34 4 is be VBZ cord-286607-5i406twr 34 5 prone prone JJ cord-286607-5i406twr 34 6 to to TO cord-286607-5i406twr 34 7 be be VB cord-286607-5i406twr 34 8 conditioned condition VBN cord-286607-5i406twr 34 9 by by IN cord-286607-5i406twr 34 10 the the DT cord-286607-5i406twr 34 11 type type NN cord-286607-5i406twr 34 12 of of IN cord-286607-5i406twr 34 13 delivery delivery NN cord-286607-5i406twr 34 14 ; ; : cord-286607-5i406twr 34 15 the the DT cord-286607-5i406twr 34 16 mother mother NN cord-286607-5i406twr 34 17 's 's POS cord-286607-5i406twr 34 18 vaginal vaginal JJ cord-286607-5i406twr 34 19 flora flora NNS cord-286607-5i406twr 34 20 is be VBZ cord-286607-5i406twr 34 21 a a DT cord-286607-5i406twr 34 22 relevant relevant JJ cord-286607-5i406twr 34 23 source source NN cord-286607-5i406twr 34 24 of of IN cord-286607-5i406twr 34 25 Lactobacillus lactobacillus NN cord-286607-5i406twr 34 26 , , , cord-286607-5i406twr 34 27 Prevotella Prevotella NNP cord-286607-5i406twr 34 28 , , , cord-286607-5i406twr 34 29 and and CC cord-286607-5i406twr 34 30 Bifidobacterium bifidobacterium NN cord-286607-5i406twr 34 31 . . . cord-286607-5i406twr 35 1 Conversely conversely RB cord-286607-5i406twr 35 2 , , , cord-286607-5i406twr 35 3 a a DT cord-286607-5i406twr 35 4 cesarean cesarean NN cord-286607-5i406twr 35 5 delivery delivery NN cord-286607-5i406twr 35 6 delays delay NNS cord-286607-5i406twr 35 7 contact contact VBP cord-286607-5i406twr 35 8 with with IN cord-286607-5i406twr 35 9 these these DT cord-286607-5i406twr 35 10 species specie NNS cord-286607-5i406twr 35 11 , , , cord-286607-5i406twr 35 12 producing produce VBG cord-286607-5i406twr 35 13 a a DT cord-286607-5i406twr 35 14 similar similar JJ cord-286607-5i406twr 35 15 - - HYPH cord-286607-5i406twr 35 16 to to IN cord-286607-5i406twr 35 17 - - HYPH cord-286607-5i406twr 35 18 skin skin NN cord-286607-5i406twr 35 19 flora flora NNS cord-286607-5i406twr 35 20 , , , cord-286607-5i406twr 35 21 dominated dominate VBN cord-286607-5i406twr 35 22 by by IN cord-286607-5i406twr 35 23 Staphylococci Staphylococci NNP cord-286607-5i406twr 35 24 ( ( -LRB- cord-286607-5i406twr 35 25 18 18 CD cord-286607-5i406twr 35 26 ) ) -RRB- cord-286607-5i406twr 35 27 . . . cord-286607-5i406twr 36 1 The the DT cord-286607-5i406twr 36 2 feeding feed VBG cord-286607-5i406twr 36 3 regimens regimen NNS cord-286607-5i406twr 36 4 and and CC cord-286607-5i406twr 36 5 food food NN cord-286607-5i406twr 36 6 supplements supplement NNS cord-286607-5i406twr 36 7 also also RB cord-286607-5i406twr 36 8 play play VBP cord-286607-5i406twr 36 9 a a DT cord-286607-5i406twr 36 10 role role NN cord-286607-5i406twr 36 11 in in IN cord-286607-5i406twr 36 12 modifying modify VBG cord-286607-5i406twr 36 13 the the DT cord-286607-5i406twr 36 14 resident resident JJ cord-286607-5i406twr 36 15 flora flora NNS cord-286607-5i406twr 36 16 ; ; : cord-286607-5i406twr 36 17 a a DT cord-286607-5i406twr 36 18 greater great JJR cord-286607-5i406twr 36 19 complexity complexity NN cord-286607-5i406twr 36 20 is be VBZ cord-286607-5i406twr 36 21 normally normally RB cord-286607-5i406twr 36 22 seen see VBN cord-286607-5i406twr 36 23 in in IN cord-286607-5i406twr 36 24 infants infant NNS cord-286607-5i406twr 36 25 fed feed VBN cord-286607-5i406twr 36 26 with with IN cord-286607-5i406twr 36 27 formula formula NN cord-286607-5i406twr 36 28 , , , cord-286607-5i406twr 36 29 rather rather RB cord-286607-5i406twr 36 30 than than IN cord-286607-5i406twr 36 31 in in IN cord-286607-5i406twr 36 32 breastfed breastfed JJ cord-286607-5i406twr 36 33 babies baby NNS cord-286607-5i406twr 36 34 who who WP cord-286607-5i406twr 36 35 have have VBP cord-286607-5i406twr 36 36 an an DT cord-286607-5i406twr 36 37 " " `` cord-286607-5i406twr 36 38 adult adult NN cord-286607-5i406twr 36 39 - - HYPH cord-286607-5i406twr 36 40 like like JJ cord-286607-5i406twr 36 41 " " `` cord-286607-5i406twr 36 42 structured structured JJ cord-286607-5i406twr 36 43 microbiota microbiota NN cord-286607-5i406twr 36 44 with with IN cord-286607-5i406twr 36 45 a a DT cord-286607-5i406twr 36 46 population population NN cord-286607-5i406twr 36 47 rich rich JJ cord-286607-5i406twr 36 48 with with IN cord-286607-5i406twr 36 49 Bifidobacteria Bifidobacteria NNP cord-286607-5i406twr 36 50 , , , cord-286607-5i406twr 36 51 Lactobacilli Lactobacilli NNP cord-286607-5i406twr 36 52 , , , cord-286607-5i406twr 36 53 and and CC cord-286607-5i406twr 36 54 Bacteroides Bacteroides NNP cord-286607-5i406twr 36 55 ( ( -LRB- cord-286607-5i406twr 36 56 18 18 CD cord-286607-5i406twr 36 57 ) ) -RRB- cord-286607-5i406twr 36 58 . . . cord-286607-5i406twr 37 1 The the DT cord-286607-5i406twr 37 2 infant infant NN cord-286607-5i406twr 37 3 gut gut NN cord-286607-5i406twr 37 4 microbiota microbiota NN cord-286607-5i406twr 37 5 is be VBZ cord-286607-5i406twr 37 6 variable variable JJ cord-286607-5i406twr 37 7 in in IN cord-286607-5i406twr 37 8 composition composition NN cord-286607-5i406twr 37 9 over over IN cord-286607-5i406twr 37 10 time time NN cord-286607-5i406twr 37 11 and and CC cord-286607-5i406twr 37 12 highly highly RB cord-286607-5i406twr 37 13 changeable changeable JJ cord-286607-5i406twr 37 14 during during IN cord-286607-5i406twr 37 15 the the DT cord-286607-5i406twr 37 16 first first JJ cord-286607-5i406twr 37 17 year year NN cord-286607-5i406twr 37 18 of of IN cord-286607-5i406twr 37 19 life life NN cord-286607-5i406twr 37 20 , , , cord-286607-5i406twr 37 21 being be VBG cord-286607-5i406twr 37 22 influenced influence VBN cord-286607-5i406twr 37 23 by by IN cord-286607-5i406twr 37 24 specific specific JJ cord-286607-5i406twr 37 25 bacteria bacteria NNS cord-286607-5i406twr 37 26 to to TO cord-286607-5i406twr 37 27 which which WDT cord-286607-5i406twr 37 28 a a DT cord-286607-5i406twr 37 29 baby baby NN cord-286607-5i406twr 37 30 happens happen VBZ cord-286607-5i406twr 37 31 to to TO cord-286607-5i406twr 37 32 be be VB cord-286607-5i406twr 37 33 exposed expose VBN cord-286607-5i406twr 37 34 , , , cord-286607-5i406twr 37 35 as as IN cord-286607-5i406twr 37 36 shown show VBN cord-286607-5i406twr 37 37 by by IN cord-286607-5i406twr 37 38 the the DT cord-286607-5i406twr 37 39 resemblance resemblance NN cord-286607-5i406twr 37 40 of of IN cord-286607-5i406twr 37 41 infants infant NNS cord-286607-5i406twr 37 42 ' ' POS cord-286607-5i406twr 37 43 stool stool NN cord-286607-5i406twr 37 44 microbial microbial JJ cord-286607-5i406twr 37 45 community community NN cord-286607-5i406twr 37 46 with with IN cord-286607-5i406twr 37 47 mothers mother NNS cord-286607-5i406twr 37 48 ' ' POS cord-286607-5i406twr 37 49 milk milk NN cord-286607-5i406twr 37 50 and and CC cord-286607-5i406twr 37 51 vaginal vaginal JJ cord-286607-5i406twr 37 52 samples sample NNS cord-286607-5i406twr 37 53 ( ( -LRB- cord-286607-5i406twr 37 54 19 19 CD cord-286607-5i406twr 37 55 ) ) -RRB- cord-286607-5i406twr 37 56 . . . cord-286607-5i406twr 38 1 Thereafter thereafter RB cord-286607-5i406twr 38 2 , , , cord-286607-5i406twr 38 3 the the DT cord-286607-5i406twr 38 4 infant infant NN cord-286607-5i406twr 38 5 's 's POS cord-286607-5i406twr 38 6 intestinal intestinal JJ cord-286607-5i406twr 38 7 tract tract NN cord-286607-5i406twr 38 8 progresses progress VBZ cord-286607-5i406twr 38 9 toward toward IN cord-286607-5i406twr 38 10 an an DT cord-286607-5i406twr 38 11 extremely extremely RB cord-286607-5i406twr 38 12 dense dense JJ cord-286607-5i406twr 38 13 colonization colonization NN cord-286607-5i406twr 38 14 , , , cord-286607-5i406twr 38 15 ending end VBG cord-286607-5i406twr 38 16 with with IN cord-286607-5i406twr 38 17 a a DT cord-286607-5i406twr 38 18 mixture mixture NN cord-286607-5i406twr 38 19 of of IN cord-286607-5i406twr 38 20 microbes microbe NNS cord-286607-5i406twr 38 21 that that WDT cord-286607-5i406twr 38 22 is be VBZ cord-286607-5i406twr 38 23 broadly broadly RB cord-286607-5i406twr 38 24 very very RB cord-286607-5i406twr 38 25 similar similar JJ cord-286607-5i406twr 38 26 to to IN cord-286607-5i406twr 38 27 an an DT cord-286607-5i406twr 38 28 adult adult NN cord-286607-5i406twr 38 29 's 's POS cord-286607-5i406twr 38 30 intestine intestine NN cord-286607-5i406twr 38 31 . . . cord-286607-5i406twr 39 1 During during IN cord-286607-5i406twr 39 2 adulthood adulthood NN cord-286607-5i406twr 39 3 , , , cord-286607-5i406twr 39 4 the the DT cord-286607-5i406twr 39 5 gut gut NN cord-286607-5i406twr 39 6 microbiota microbiota NN cord-286607-5i406twr 39 7 becomes become VBZ cord-286607-5i406twr 39 8 stable stable JJ cord-286607-5i406twr 39 9 and and CC cord-286607-5i406twr 39 10 this this DT cord-286607-5i406twr 39 11 intestinal intestinal JJ cord-286607-5i406twr 39 12 homeostasis homeostasis NN cord-286607-5i406twr 39 13 remains remain VBZ cord-286607-5i406twr 39 14 in in IN cord-286607-5i406twr 39 15 equilibrium equilibrium NN cord-286607-5i406twr 39 16 with with IN cord-286607-5i406twr 39 17 the the DT cord-286607-5i406twr 39 18 host host NN cord-286607-5i406twr 39 19 . . . cord-286607-5i406twr 40 1 Food food NN cord-286607-5i406twr 40 2 habits habit NNS cord-286607-5i406twr 40 3 influence influence VBP cord-286607-5i406twr 40 4 the the DT cord-286607-5i406twr 40 5 composition composition NN cord-286607-5i406twr 40 6 of of IN cord-286607-5i406twr 40 7 the the DT cord-286607-5i406twr 40 8 whole whole JJ cord-286607-5i406twr 40 9 intestinal intestinal JJ cord-286607-5i406twr 40 10 microbiota microbiota NN cord-286607-5i406twr 40 11 , , , cord-286607-5i406twr 40 12 as as IN cord-286607-5i406twr 40 13 testified testify VBN cord-286607-5i406twr 40 14 by by IN cord-286607-5i406twr 40 15 the the DT cord-286607-5i406twr 40 16 lower low JJR cord-286607-5i406twr 40 17 prevalence prevalence NN cord-286607-5i406twr 40 18 of of IN cord-286607-5i406twr 40 19 Bacteroides Bacteroides NNP cord-286607-5i406twr 40 20 in in IN cord-286607-5i406twr 40 21 those those DT cord-286607-5i406twr 40 22 suffering suffer VBG cord-286607-5i406twr 40 23 from from IN cord-286607-5i406twr 40 24 malnutrition malnutrition NN cord-286607-5i406twr 40 25 and and CC cord-286607-5i406twr 40 26 by by IN cord-286607-5i406twr 40 27 different different JJ cord-286607-5i406twr 40 28 microbiota microbiota NN cord-286607-5i406twr 40 29 changes change NNS cord-286607-5i406twr 40 30 occurring occur VBG cord-286607-5i406twr 40 31 in in IN cord-286607-5i406twr 40 32 children child NNS cord-286607-5i406twr 40 33 with with IN cord-286607-5i406twr 40 34 diet diet NN cord-286607-5i406twr 40 35 - - HYPH cord-286607-5i406twr 40 36 related relate VBN cord-286607-5i406twr 40 37 diseases disease NNS cord-286607-5i406twr 40 38 , , , cord-286607-5i406twr 40 39 such such JJ cord-286607-5i406twr 40 40 as as IN cord-286607-5i406twr 40 41 allergies allergy NNS cord-286607-5i406twr 40 42 and and CC cord-286607-5i406twr 40 43 obesity obesity NN cord-286607-5i406twr 40 44 ( ( -LRB- cord-286607-5i406twr 40 45 19 19 CD cord-286607-5i406twr 40 46 ) ) -RRB- cord-286607-5i406twr 40 47 . . . cord-286607-5i406twr 41 1 Arumugam Arumugam NNP cord-286607-5i406twr 41 2 et et NNP cord-286607-5i406twr 41 3 al al NNP cord-286607-5i406twr 41 4 . . NNP cord-286607-5i406twr 41 5 identified identify VBD cord-286607-5i406twr 41 6 three three CD cord-286607-5i406twr 41 7 distinct distinct JJ cord-286607-5i406twr 41 8 enterotypes enterotype NNS cord-286607-5i406twr 41 9 , , , cord-286607-5i406twr 41 10 namely namely RB cord-286607-5i406twr 41 11 Bacteroides Bacteroides NNP cord-286607-5i406twr 41 12 , , , cord-286607-5i406twr 41 13 Prevotella Prevotella NNP cord-286607-5i406twr 41 14 , , , cord-286607-5i406twr 41 15 and and CC cord-286607-5i406twr 41 16 Ruminococcus Ruminococcus NNP cord-286607-5i406twr 41 17 , , , cord-286607-5i406twr 41 18 which which WDT cord-286607-5i406twr 41 19 reflect reflect VBP cord-286607-5i406twr 41 20 many many JJ cord-286607-5i406twr 41 21 individual individual JJ cord-286607-5i406twr 41 22 alimentary alimentary JJ cord-286607-5i406twr 41 23 profiles profile NNS cord-286607-5i406twr 41 24 : : : cord-286607-5i406twr 42 1 Bacteroides Bacteroides NNP cord-286607-5i406twr 42 2 correlates correlate VBZ cord-286607-5i406twr 42 3 to to IN cord-286607-5i406twr 42 4 a a DT cord-286607-5i406twr 42 5 highfat highfat JJ cord-286607-5i406twr 42 6 or or CC cord-286607-5i406twr 42 7 high high JJ cord-286607-5i406twr 42 8 - - HYPH cord-286607-5i406twr 42 9 protein protein NN cord-286607-5i406twr 42 10 regimen regimen NN cord-286607-5i406twr 42 11 , , , cord-286607-5i406twr 42 12 whereas whereas IN cord-286607-5i406twr 42 13 Prevotella Prevotella NNP cord-286607-5i406twr 42 14 is be VBZ cord-286607-5i406twr 42 15 associated associate VBN cord-286607-5i406twr 42 16 with with IN cord-286607-5i406twr 42 17 higher high JJR cord-286607-5i406twr 42 18 consumption consumption NN cord-286607-5i406twr 42 19 of of IN cord-286607-5i406twr 42 20 fibers fiber NNS cord-286607-5i406twr 42 21 and and CC cord-286607-5i406twr 42 22 simple simple JJ cord-286607-5i406twr 42 23 sugars sugar NNS cord-286607-5i406twr 42 24 ( ( -LRB- cord-286607-5i406twr 42 25 20 20 CD cord-286607-5i406twr 42 26 ) ) -RRB- cord-286607-5i406twr 42 27 . . . cord-286607-5i406twr 43 1 More More JJR cord-286607-5i406twr 43 2 recent recent JJ cord-286607-5i406twr 43 3 data datum NNS cord-286607-5i406twr 43 4 have have VBP cord-286607-5i406twr 43 5 consented consent VBN cord-286607-5i406twr 43 6 to to TO cord-286607-5i406twr 43 7 unify unify VB cord-286607-5i406twr 43 8 Bacteroides Bacteroides NNP cord-286607-5i406twr 43 9 and and CC cord-286607-5i406twr 43 10 Ruminococcus Ruminococcus NNP cord-286607-5i406twr 43 11 enterotypes enterotype NNS cord-286607-5i406twr 43 12 due due IN cord-286607-5i406twr 43 13 to to IN cord-286607-5i406twr 43 14 the the DT cord-286607-5i406twr 43 15 large large JJ cord-286607-5i406twr 43 16 similarity similarity NN cord-286607-5i406twr 43 17 between between IN cord-286607-5i406twr 43 18 the the DT cord-286607-5i406twr 43 19 two two CD cord-286607-5i406twr 43 20 ( ( -LRB- cord-286607-5i406twr 43 21 21 21 CD cord-286607-5i406twr 43 22 ) ) -RRB- cord-286607-5i406twr 43 23 . . . cord-286607-5i406twr 44 1 It -PRON- PRP cord-286607-5i406twr 44 2 is be VBZ cord-286607-5i406twr 44 3 well well RB cord-286607-5i406twr 44 4 - - HYPH cord-286607-5i406twr 44 5 established establish VBN cord-286607-5i406twr 44 6 that that IN cord-286607-5i406twr 44 7 early early JJ cord-286607-5i406twr 44 8 events event NNS cord-286607-5i406twr 44 9 of of IN cord-286607-5i406twr 44 10 birth birth NN cord-286607-5i406twr 44 11 , , , cord-286607-5i406twr 44 12 environmental environmental JJ cord-286607-5i406twr 44 13 factors factor NNS cord-286607-5i406twr 44 14 during during IN cord-286607-5i406twr 44 15 infancy infancy NN cord-286607-5i406twr 44 16 , , , cord-286607-5i406twr 44 17 sex sex NN cord-286607-5i406twr 44 18 hormones hormone NNS cord-286607-5i406twr 44 19 , , , cord-286607-5i406twr 44 20 diet diet NN cord-286607-5i406twr 44 21 , , , cord-286607-5i406twr 44 22 body body NN cord-286607-5i406twr 44 23 weight weight NN cord-286607-5i406twr 44 24 , , , cord-286607-5i406twr 44 25 and and CC cord-286607-5i406twr 44 26 use use NN cord-286607-5i406twr 44 27 of of IN cord-286607-5i406twr 44 28 antibiotics antibiotic NNS cord-286607-5i406twr 44 29 can can MD cord-286607-5i406twr 44 30 undoubtedly undoubtedly RB cord-286607-5i406twr 44 31 differentiate differentiate VB cord-286607-5i406twr 44 32 the the DT cord-286607-5i406twr 44 33 composition composition NN cord-286607-5i406twr 44 34 of of IN cord-286607-5i406twr 44 35 the the DT cord-286607-5i406twr 44 36 microbiota microbiota NN cord-286607-5i406twr 44 37 ( ( -LRB- cord-286607-5i406twr 44 38 22 22 CD cord-286607-5i406twr 44 39 , , , cord-286607-5i406twr 44 40 23 23 CD cord-286607-5i406twr 44 41 ) ) -RRB- cord-286607-5i406twr 44 42 . . . cord-286607-5i406twr 45 1 There there EX cord-286607-5i406twr 45 2 are be VBP cord-286607-5i406twr 45 3 no no DT cord-286607-5i406twr 45 4 ideal ideal JJ cord-286607-5i406twr 45 5 culture culture NN cord-286607-5i406twr 45 6 methods method NNS cord-286607-5i406twr 45 7 to to TO cord-286607-5i406twr 45 8 give give VB cord-286607-5i406twr 45 9 us -PRON- PRP cord-286607-5i406twr 45 10 a a DT cord-286607-5i406twr 45 11 real real JJ cord-286607-5i406twr 45 12 overview overview NN cord-286607-5i406twr 45 13 of of IN cord-286607-5i406twr 45 14 the the DT cord-286607-5i406twr 45 15 complete complete JJ cord-286607-5i406twr 45 16 intestinal intestinal JJ cord-286607-5i406twr 45 17 flora flora NNS cord-286607-5i406twr 45 18 , , , cord-286607-5i406twr 45 19 though though IN cord-286607-5i406twr 45 20 molecular molecular JJ cord-286607-5i406twr 45 21 methods method NNS cord-286607-5i406twr 45 22 , , , cord-286607-5i406twr 45 23 e.g. e.g. RB cord-286607-5i406twr 45 24 , , , cord-286607-5i406twr 45 25 DNA dna NN cord-286607-5i406twr 45 26 microarrays microarray NNS cord-286607-5i406twr 45 27 with with IN cord-286607-5i406twr 45 28 comprehensive comprehensive JJ cord-286607-5i406twr 45 29 coverage coverage NN cord-286607-5i406twr 45 30 of of IN cord-286607-5i406twr 45 31 most most JJS cord-286607-5i406twr 45 32 bacterial bacterial JJ cord-286607-5i406twr 45 33 taxa taxon NNS cord-286607-5i406twr 45 34 represented represent VBN cord-286607-5i406twr 45 35 in in IN cord-286607-5i406twr 45 36 the the DT cord-286607-5i406twr 45 37 available available JJ cord-286607-5i406twr 45 38 database database NN cord-286607-5i406twr 45 39 of of IN cord-286607-5i406twr 45 40 small small JJ cord-286607-5i406twr 45 41 subunit subunit NN cord-286607-5i406twr 45 42 ribosomal ribosomal VBG cord-286607-5i406twr 45 43 RNA RNA NNP cord-286607-5i406twr 45 44 gene gene NN cord-286607-5i406twr 45 45 sequences sequence NNS cord-286607-5i406twr 45 46 , , , cord-286607-5i406twr 45 47 should should MD cord-286607-5i406twr 45 48 allow allow VB cord-286607-5i406twr 45 49 the the DT cord-286607-5i406twr 45 50 characterization characterization NN cord-286607-5i406twr 45 51 of of IN cord-286607-5i406twr 45 52 most most JJS cord-286607-5i406twr 45 53 taxonomic taxonomic JJ cord-286607-5i406twr 45 54 groups group NNS cord-286607-5i406twr 45 55 of of IN cord-286607-5i406twr 45 56 the the DT cord-286607-5i406twr 45 57 intestinal intestinal JJ cord-286607-5i406twr 45 58 bacteria bacteria NNS cord-286607-5i406twr 45 59 ( ( -LRB- cord-286607-5i406twr 45 60 24 24 CD cord-286607-5i406twr 45 61 , , , cord-286607-5i406twr 45 62 25 25 CD cord-286607-5i406twr 45 63 ) ) -RRB- cord-286607-5i406twr 45 64 . . . cord-286607-5i406twr 46 1 The the DT cord-286607-5i406twr 46 2 ancient ancient JJ cord-286607-5i406twr 46 3 symbiosis symbiosis NN cord-286607-5i406twr 46 4 between between IN cord-286607-5i406twr 46 5 the the DT cord-286607-5i406twr 46 6 human human JJ cord-286607-5i406twr 46 7 gastrointestinal gastrointestinal JJ cord-286607-5i406twr 46 8 tract tract NN cord-286607-5i406twr 46 9 and and CC cord-286607-5i406twr 46 10 its -PRON- PRP$ cord-286607-5i406twr 46 11 resident resident JJ cord-286607-5i406twr 46 12 microbiota microbiota NN cord-286607-5i406twr 46 13 involves involve VBZ cord-286607-5i406twr 46 14 diverse diverse JJ cord-286607-5i406twr 46 15 reciprocal reciprocal JJ cord-286607-5i406twr 46 16 interactions interaction NNS cord-286607-5i406twr 46 17 between between IN cord-286607-5i406twr 46 18 the the DT cord-286607-5i406twr 46 19 microbiota microbiota NN cord-286607-5i406twr 46 20 itself -PRON- PRP cord-286607-5i406twr 46 21 and and CC cord-286607-5i406twr 46 22 the the DT cord-286607-5i406twr 46 23 host host NN cord-286607-5i406twr 46 24 , , , cord-286607-5i406twr 46 25 with with IN cord-286607-5i406twr 46 26 relevant relevant JJ cord-286607-5i406twr 46 27 consequences consequence NNS cord-286607-5i406twr 46 28 for for IN cord-286607-5i406twr 46 29 human human JJ cord-286607-5i406twr 46 30 health health NN cord-286607-5i406twr 46 31 and and CC cord-286607-5i406twr 46 32 physiology physiology NN cord-286607-5i406twr 46 33 . . . cord-286607-5i406twr 47 1 The the DT cord-286607-5i406twr 47 2 quality quality NN cord-286607-5i406twr 47 3 of of IN cord-286607-5i406twr 47 4 the the DT cord-286607-5i406twr 47 5 microbial microbial JJ cord-286607-5i406twr 47 6 flora flora NNP cord-286607-5i406twr 47 7 has have VBZ cord-286607-5i406twr 47 8 an an DT cord-286607-5i406twr 47 9 impact impact NN cord-286607-5i406twr 47 10 on on IN cord-286607-5i406twr 47 11 the the DT cord-286607-5i406twr 47 12 maintenance maintenance NN cord-286607-5i406twr 47 13 of of IN cord-286607-5i406twr 47 14 health health NN cord-286607-5i406twr 47 15 and and CC cord-286607-5i406twr 47 16 also also RB cord-286607-5i406twr 47 17 on on IN cord-286607-5i406twr 47 18 prevention prevention NN cord-286607-5i406twr 47 19 of of IN cord-286607-5i406twr 47 20 diseases disease NNS cord-286607-5i406twr 47 21 . . . cord-286607-5i406twr 48 1 Indeed indeed RB cord-286607-5i406twr 48 2 , , , cord-286607-5i406twr 48 3 there there EX cord-286607-5i406twr 48 4 are be VBP cord-286607-5i406twr 48 5 numerous numerous JJ cord-286607-5i406twr 48 6 roles role NNS cord-286607-5i406twr 48 7 carried carry VBN cord-286607-5i406twr 48 8 out out RP cord-286607-5i406twr 48 9 by by IN cord-286607-5i406twr 48 10 the the DT cord-286607-5i406twr 48 11 intestinal intestinal JJ cord-286607-5i406twr 48 12 ecosystem ecosystem NN cord-286607-5i406twr 48 13 , , , cord-286607-5i406twr 48 14 as as IN cord-286607-5i406twr 48 15 the the DT cord-286607-5i406twr 48 16 stimulation stimulation NN cord-286607-5i406twr 48 17 of of IN cord-286607-5i406twr 48 18 angiogenesis angiogenesis NN cord-286607-5i406twr 48 19 , , , cord-286607-5i406twr 48 20 control control NN cord-286607-5i406twr 48 21 of of IN cord-286607-5i406twr 48 22 host host NN cord-286607-5i406twr 48 23 fat fat JJ cord-286607-5i406twr 48 24 storage storage NN cord-286607-5i406twr 48 25 and and CC cord-286607-5i406twr 48 26 protection protection NN cord-286607-5i406twr 48 27 against against IN cord-286607-5i406twr 48 28 other other JJ cord-286607-5i406twr 48 29 pathogens pathogen NNS cord-286607-5i406twr 48 30 . . . cord-286607-5i406twr 49 1 In in IN cord-286607-5i406twr 49 2 particular particular JJ cord-286607-5i406twr 49 3 , , , cord-286607-5i406twr 49 4 the the DT cord-286607-5i406twr 49 5 microbiota microbiota NN cord-286607-5i406twr 49 6 influences influence VBZ cord-286607-5i406twr 49 7 the the DT cord-286607-5i406twr 49 8 formation formation NN cord-286607-5i406twr 49 9 and and CC cord-286607-5i406twr 49 10 progress progress NN cord-286607-5i406twr 49 11 of of IN cord-286607-5i406twr 49 12 regulation regulation NN cord-286607-5i406twr 49 13 of of IN cord-286607-5i406twr 49 14 both both DT cord-286607-5i406twr 49 15 innate innate JJ cord-286607-5i406twr 49 16 and and CC cord-286607-5i406twr 49 17 adaptive adaptive JJ cord-286607-5i406twr 49 18 immunity immunity NN cord-286607-5i406twr 49 19 in in IN cord-286607-5i406twr 49 20 close close JJ cord-286607-5i406twr 49 21 interaction interaction NN cord-286607-5i406twr 49 22 with with IN cord-286607-5i406twr 49 23 the the DT cord-286607-5i406twr 49 24 intestinal intestinal JJ cord-286607-5i406twr 49 25 mucosal mucosal JJ cord-286607-5i406twr 49 26 immune immune JJ cord-286607-5i406twr 49 27 system system NN cord-286607-5i406twr 49 28 . . . cord-286607-5i406twr 50 1 The the DT cord-286607-5i406twr 50 2 intestinal intestinal JJ cord-286607-5i406twr 50 3 mucosa mucosa NN cord-286607-5i406twr 50 4 may may MD cord-286607-5i406twr 50 5 be be VB cord-286607-5i406twr 50 6 considered consider VBN cord-286607-5i406twr 50 7 as as IN cord-286607-5i406twr 50 8 an an DT cord-286607-5i406twr 50 9 immunological immunological JJ cord-286607-5i406twr 50 10 niche niche NN cord-286607-5i406twr 50 11 as as IN cord-286607-5i406twr 50 12 it -PRON- PRP cord-286607-5i406twr 50 13 hosts host VBZ cord-286607-5i406twr 50 14 a a DT cord-286607-5i406twr 50 15 complex complex JJ cord-286607-5i406twr 50 16 immune immune JJ cord-286607-5i406twr 50 17 - - HYPH cord-286607-5i406twr 50 18 functional functional JJ cord-286607-5i406twr 50 19 organ organ NN cord-286607-5i406twr 50 20 comprised comprise VBN cord-286607-5i406twr 50 21 by by IN cord-286607-5i406twr 50 22 T T NNP cord-286607-5i406twr 50 23 cell cell NN cord-286607-5i406twr 50 24 subpopulations subpopulation NNS cord-286607-5i406twr 50 25 , , , cord-286607-5i406twr 50 26 neutrophils neutrophil NNS cord-286607-5i406twr 50 27 , , , cord-286607-5i406twr 50 28 macrophage macrophage NN cord-286607-5i406twr 50 29 - - HYPH cord-286607-5i406twr 50 30 dendritic dendritic JJ cord-286607-5i406twr 50 31 cells cell NNS cord-286607-5i406twr 50 32 , , , cord-286607-5i406twr 50 33 enterocytes enterocytes NNP cord-286607-5i406twr 50 34 ( ( -LRB- cord-286607-5i406twr 50 35 that that WDT cord-286607-5i406twr 50 36 possess possess VBP cord-286607-5i406twr 50 37 tight tight JJ cord-286607-5i406twr 50 38 intercellular intercellular JJ cord-286607-5i406twr 50 39 junctions junction NNS cord-286607-5i406twr 50 40 ) ) -RRB- cord-286607-5i406twr 50 41 and and CC cord-286607-5i406twr 50 42 their -PRON- PRP$ cord-286607-5i406twr 50 43 related relate VBN cord-286607-5i406twr 50 44 anti anti JJ cord-286607-5i406twr 50 45 - - JJ cord-286607-5i406twr 50 46 and and CC cord-286607-5i406twr 50 47 pro pro JJ cord-286607-5i406twr 50 48 - - JJ cord-286607-5i406twr 50 49 inflammatory inflammatory JJ cord-286607-5i406twr 50 50 cytokines cytokine NNS cord-286607-5i406twr 50 51 as as RB cord-286607-5i406twr 50 52 well well RB cord-286607-5i406twr 50 53 as as IN cord-286607-5i406twr 50 54 several several JJ cord-286607-5i406twr 50 55 other other JJ cord-286607-5i406twr 50 56 mediators mediator NNS cord-286607-5i406twr 50 57 of of IN cord-286607-5i406twr 50 58 inflammation inflammation NN cord-286607-5i406twr 50 59 or or CC cord-286607-5i406twr 50 60 antimicrobial antimicrobial JJ cord-286607-5i406twr 50 61 peptides peptide NNS cord-286607-5i406twr 50 62 , , , cord-286607-5i406twr 50 63 defensins defensin NNS cord-286607-5i406twr 50 64 , , , cord-286607-5i406twr 50 65 and and CC cord-286607-5i406twr 50 66 secretory secretory JJ cord-286607-5i406twr 50 67 immunoglobulin immunoglobulin NN cord-286607-5i406twr 50 68 A a NN cord-286607-5i406twr 50 69 ( ( -LRB- cord-286607-5i406twr 50 70 IgA IgA NNP cord-286607-5i406twr 50 71 ) ) -RRB- cord-286607-5i406twr 50 72 ( ( -LRB- cord-286607-5i406twr 50 73 26 26 CD cord-286607-5i406twr 50 74 ) ) -RRB- cord-286607-5i406twr 50 75 . . . cord-286607-5i406twr 51 1 The the DT cord-286607-5i406twr 51 2 intestinal intestinal JJ cord-286607-5i406twr 51 3 microbiota microbiota NN cord-286607-5i406twr 51 4 may may MD cord-286607-5i406twr 51 5 also also RB cord-286607-5i406twr 51 6 have have VB cord-286607-5i406twr 51 7 direct direct JJ cord-286607-5i406twr 51 8 or or CC cord-286607-5i406twr 51 9 indirect indirect JJ cord-286607-5i406twr 51 10 effects effect NNS cord-286607-5i406twr 51 11 on on IN cord-286607-5i406twr 51 12 the the DT cord-286607-5i406twr 51 13 natural natural JJ cord-286607-5i406twr 51 14 course course NN cord-286607-5i406twr 51 15 of of IN cord-286607-5i406twr 51 16 viral viral JJ cord-286607-5i406twr 51 17 infections infection NNS cord-286607-5i406twr 51 18 , , , cord-286607-5i406twr 51 19 interacting interact VBG cord-286607-5i406twr 51 20 with with IN cord-286607-5i406twr 51 21 viral viral JJ cord-286607-5i406twr 51 22 particles particle NNS cord-286607-5i406twr 51 23 and and CC cord-286607-5i406twr 51 24 leading lead VBG cord-286607-5i406twr 51 25 to to IN cord-286607-5i406twr 51 26 differences difference NNS cord-286607-5i406twr 51 27 in in IN cord-286607-5i406twr 51 28 either either DT cord-286607-5i406twr 51 29 pathogenicity pathogenicity NN cord-286607-5i406twr 51 30 or or CC cord-286607-5i406twr 51 31 anti anti JJ cord-286607-5i406twr 51 32 - - JJ cord-286607-5i406twr 51 33 viral viral JJ cord-286607-5i406twr 51 34 immune immune JJ cord-286607-5i406twr 51 35 response response NN cord-286607-5i406twr 51 36 through through IN cord-286607-5i406twr 51 37 recruitment recruitment NN cord-286607-5i406twr 51 38 and and CC cord-286607-5i406twr 51 39 activation activation NN cord-286607-5i406twr 51 40 of of IN cord-286607-5i406twr 51 41 several several JJ cord-286607-5i406twr 51 42 T t NN cord-286607-5i406twr 51 43 cell cell NN cord-286607-5i406twr 51 44 subpopulations subpopulation NNS cord-286607-5i406twr 51 45 ( ( -LRB- cord-286607-5i406twr 51 46 18 18 CD cord-286607-5i406twr 51 47 ) ) -RRB- cord-286607-5i406twr 51 48 . . . cord-286607-5i406twr 52 1 A a DT cord-286607-5i406twr 52 2 large large JJ cord-286607-5i406twr 52 3 amount amount NN cord-286607-5i406twr 52 4 of of IN cord-286607-5i406twr 52 5 data datum NNS cord-286607-5i406twr 52 6 has have VBZ cord-286607-5i406twr 52 7 also also RB cord-286607-5i406twr 52 8 depicted depict VBN cord-286607-5i406twr 52 9 the the DT cord-286607-5i406twr 52 10 relevance relevance NN cord-286607-5i406twr 52 11 of of IN cord-286607-5i406twr 52 12 gut gut NN cord-286607-5i406twr 52 13 microbiota microbiota NN cord-286607-5i406twr 52 14 - - HYPH cord-286607-5i406twr 52 15 immune immune JJ cord-286607-5i406twr 52 16 system system NN cord-286607-5i406twr 52 17 cross cross NN cord-286607-5i406twr 52 18 - - NN cord-286607-5i406twr 52 19 talk talk NN cord-286607-5i406twr 52 20 in in IN cord-286607-5i406twr 52 21 several several JJ cord-286607-5i406twr 52 22 diseases disease NNS cord-286607-5i406twr 52 23 , , , cord-286607-5i406twr 52 24 and and CC cord-286607-5i406twr 52 25 indeed indeed RB cord-286607-5i406twr 52 26 an an DT cord-286607-5i406twr 52 27 " " `` cord-286607-5i406twr 52 28 imbalance imbalance NN cord-286607-5i406twr 52 29 " " '' cord-286607-5i406twr 52 30 of of IN cord-286607-5i406twr 52 31 the the DT cord-286607-5i406twr 52 32 intestinal intestinal JJ cord-286607-5i406twr 52 33 flora flora NNS cord-286607-5i406twr 52 34 has have VBZ cord-286607-5i406twr 52 35 been be VBN cord-286607-5i406twr 52 36 shown show VBN cord-286607-5i406twr 52 37 in in IN cord-286607-5i406twr 52 38 patients patient NNS cord-286607-5i406twr 52 39 with with IN cord-286607-5i406twr 52 40 atopic atopic JJ cord-286607-5i406twr 52 41 diseases disease NNS cord-286607-5i406twr 52 42 and and CC cord-286607-5i406twr 52 43 various various JJ cord-286607-5i406twr 52 44 noninfectious noninfectious JJ cord-286607-5i406twr 52 45 diseases disease NNS cord-286607-5i406twr 52 46 , , , cord-286607-5i406twr 52 47 including include VBG cord-286607-5i406twr 52 48 metabolic metabolic JJ cord-286607-5i406twr 52 49 disorders disorder NNS cord-286607-5i406twr 52 50 , , , cord-286607-5i406twr 52 51 chronic chronic JJ cord-286607-5i406twr 52 52 inflammatory inflammatory JJ cord-286607-5i406twr 52 53 bowel bowel NN cord-286607-5i406twr 52 54 disease disease NN cord-286607-5i406twr 52 55 ( ( -LRB- cord-286607-5i406twr 52 56 IBD IBD NNP cord-286607-5i406twr 52 57 ) ) -RRB- cord-286607-5i406twr 52 58 , , , cord-286607-5i406twr 52 59 irritable irritable JJ cord-286607-5i406twr 52 60 bowel bowel NN cord-286607-5i406twr 52 61 syndrome syndrome NN cord-286607-5i406twr 52 62 , , , cord-286607-5i406twr 52 63 pancreatic pancreatic JJ cord-286607-5i406twr 52 64 diseases disease NNS cord-286607-5i406twr 52 65 , , , cord-286607-5i406twr 52 66 atherosclerosis atherosclerosis NN cord-286607-5i406twr 52 67 , , , cord-286607-5i406twr 52 68 and and CC cord-286607-5i406twr 52 69 rheumatoid rheumatoid NN cord-286607-5i406twr 52 70 arthritis arthritis NN cord-286607-5i406twr 52 71 ( ( -LRB- cord-286607-5i406twr 52 72 27 27 CD cord-286607-5i406twr 52 73 , , , cord-286607-5i406twr 52 74 28 28 CD cord-286607-5i406twr 52 75 ) ) -RRB- cord-286607-5i406twr 52 76 . . . cord-286607-5i406twr 53 1 Furthermore furthermore RB cord-286607-5i406twr 53 2 , , , cord-286607-5i406twr 53 3 the the DT cord-286607-5i406twr 53 4 gut gut NN cord-286607-5i406twr 53 5 microbiota microbiota NN cord-286607-5i406twr 53 6 , , , cord-286607-5i406twr 53 7 interacting interact VBG cord-286607-5i406twr 53 8 with with IN cord-286607-5i406twr 53 9 pattern pattern NN cord-286607-5i406twr 53 10 recognition recognition NN cord-286607-5i406twr 53 11 receptors receptor NNS cord-286607-5i406twr 53 12 ( ( -LRB- cord-286607-5i406twr 53 13 PRRs PRRs NNP cord-286607-5i406twr 53 14 ) ) -RRB- cord-286607-5i406twr 53 15 , , , cord-286607-5i406twr 53 16 signaling signal VBG cord-286607-5i406twr 53 17 receptors receptor NNS cord-286607-5i406twr 53 18 that that WDT cord-286607-5i406twr 53 19 can can MD cord-286607-5i406twr 53 20 recognize recognize VB cord-286607-5i406twr 53 21 molecular molecular JJ cord-286607-5i406twr 53 22 structures structure NNS cord-286607-5i406twr 53 23 of of IN cord-286607-5i406twr 53 24 pathogens pathogen NNS cord-286607-5i406twr 53 25 and and CC cord-286607-5i406twr 53 26 activate activate VBP cord-286607-5i406twr 53 27 the the DT cord-286607-5i406twr 53 28 cascade cascade NN cord-286607-5i406twr 53 29 of of IN cord-286607-5i406twr 53 30 innate innate JJ cord-286607-5i406twr 53 31 immunity immunity NN cord-286607-5i406twr 53 32 , , , cord-286607-5i406twr 53 33 plays play VBZ cord-286607-5i406twr 53 34 a a DT cord-286607-5i406twr 53 35 crucial crucial JJ cord-286607-5i406twr 53 36 role role NN cord-286607-5i406twr 53 37 in in IN cord-286607-5i406twr 53 38 maintaining maintain VBG cord-286607-5i406twr 53 39 the the DT cord-286607-5i406twr 53 40 homeostasis homeostasis NN cord-286607-5i406twr 53 41 of of IN cord-286607-5i406twr 53 42 the the DT cord-286607-5i406twr 53 43 innate innate JJ cord-286607-5i406twr 53 44 immunity immunity NN cord-286607-5i406twr 53 45 responses response NNS cord-286607-5i406twr 53 46 in in IN cord-286607-5i406twr 53 47 the the DT cord-286607-5i406twr 53 48 gut gut NN cord-286607-5i406twr 53 49 , , , cord-286607-5i406twr 53 50 and and CC cord-286607-5i406twr 53 51 leaks leak NNS cord-286607-5i406twr 53 52 in in IN cord-286607-5i406twr 53 53 the the DT cord-286607-5i406twr 53 54 intestinal intestinal JJ cord-286607-5i406twr 53 55 mucosal mucosal JJ cord-286607-5i406twr 53 56 barrier barrier NN cord-286607-5i406twr 53 57 lead lead NN cord-286607-5i406twr 53 58 to to IN cord-286607-5i406twr 53 59 the the DT cord-286607-5i406twr 53 60 translocation translocation NN cord-286607-5i406twr 53 61 of of IN cord-286607-5i406twr 53 62 bacterial bacterial JJ cord-286607-5i406twr 53 63 products product NNS cord-286607-5i406twr 53 64 into into IN cord-286607-5i406twr 53 65 portal portal JJ cord-286607-5i406twr 53 66 circulation circulation NN cord-286607-5i406twr 53 67 which which WDT cord-286607-5i406twr 53 68 promotes promote VBZ cord-286607-5i406twr 53 69 systemic systemic JJ cord-286607-5i406twr 53 70 inflammation inflammation NN cord-286607-5i406twr 53 71 ( ( -LRB- cord-286607-5i406twr 53 72 29 29 CD cord-286607-5i406twr 53 73 ) ) -RRB- cord-286607-5i406twr 53 74 . . . cord-286607-5i406twr 54 1 In in IN cord-286607-5i406twr 54 2 addition addition NN cord-286607-5i406twr 54 3 , , , cord-286607-5i406twr 54 4 the the DT cord-286607-5i406twr 54 5 microbiota microbiota NN cord-286607-5i406twr 54 6 can can MD cord-286607-5i406twr 54 7 maintain maintain VB cord-286607-5i406twr 54 8 a a DT cord-286607-5i406twr 54 9 segregation segregation NN cord-286607-5i406twr 54 10 between between IN cord-286607-5i406twr 54 11 intestinal intestinal JJ cord-286607-5i406twr 54 12 mucosa mucosa NN cord-286607-5i406twr 54 13 and and CC cord-286607-5i406twr 54 14 bacteria bacteria NNS cord-286607-5i406twr 54 15 via via IN cord-286607-5i406twr 54 16 PRRs prr NNS cord-286607-5i406twr 54 17 , , , cord-286607-5i406twr 54 18 though though IN cord-286607-5i406twr 54 19 pathogens pathogen NNS cord-286607-5i406twr 54 20 might may MD cord-286607-5i406twr 54 21 usurp usurp VB cord-286607-5i406twr 54 22 innate innate JJ cord-286607-5i406twr 54 23 signals signal NNS cord-286607-5i406twr 54 24 to to IN cord-286607-5i406twr 54 25 their -PRON- PRP$ cord-286607-5i406twr 54 26 advantage advantage NN cord-286607-5i406twr 54 27 ( ( -LRB- cord-286607-5i406twr 54 28 30 30 CD cord-286607-5i406twr 54 29 ) ) -RRB- cord-286607-5i406twr 54 30 . . . cord-286607-5i406twr 55 1 Several several JJ cord-286607-5i406twr 55 2 immunologic immunologic JJ cord-286607-5i406twr 55 3 , , , cord-286607-5i406twr 55 4 metabolic metabolic JJ cord-286607-5i406twr 55 5 and and CC cord-286607-5i406twr 55 6 nutritional nutritional JJ cord-286607-5i406twr 55 7 processes process NNS cord-286607-5i406twr 55 8 are be VBP cord-286607-5i406twr 55 9 normally normally RB cord-286607-5i406twr 55 10 controlled control VBN cord-286607-5i406twr 55 11 by by IN cord-286607-5i406twr 55 12 the the DT cord-286607-5i406twr 55 13 intestinal intestinal JJ cord-286607-5i406twr 55 14 microbiota microbiota NN cord-286607-5i406twr 55 15 , , , cord-286607-5i406twr 55 16 and and CC cord-286607-5i406twr 55 17 changes change NNS cord-286607-5i406twr 55 18 in in IN cord-286607-5i406twr 55 19 the the DT cord-286607-5i406twr 55 20 local local JJ cord-286607-5i406twr 55 21 microbial microbial JJ cord-286607-5i406twr 55 22 communities community NNS cord-286607-5i406twr 55 23 have have VBP cord-286607-5i406twr 55 24 been be VBN cord-286607-5i406twr 55 25 linked link VBN cord-286607-5i406twr 55 26 to to IN cord-286607-5i406twr 55 27 chronic chronic JJ cord-286607-5i406twr 55 28 low low JJ cord-286607-5i406twr 55 29 - - HYPH cord-286607-5i406twr 55 30 grade grade NN cord-286607-5i406twr 55 31 inflammation inflammation NN cord-286607-5i406twr 55 32 ( ( -LRB- cord-286607-5i406twr 55 33 31 31 CD cord-286607-5i406twr 55 34 ) ) -RRB- cord-286607-5i406twr 55 35 . . . cord-286607-5i406twr 56 1 Alexander Alexander NNP cord-286607-5i406twr 56 2 et et NNP cord-286607-5i406twr 56 3 al al NNP cord-286607-5i406twr 56 4 . . NNP cord-286607-5i406twr 56 5 demonstrated demonstrate VBD cord-286607-5i406twr 56 6 that that IN cord-286607-5i406twr 56 7 the the DT cord-286607-5i406twr 56 8 microbiota microbiota NN cord-286607-5i406twr 56 9 has have VBZ cord-286607-5i406twr 56 10 specific specific JJ cord-286607-5i406twr 56 11 effects effect NNS cord-286607-5i406twr 56 12 on on IN cord-286607-5i406twr 56 13 adaptive adaptive JJ cord-286607-5i406twr 56 14 immunity immunity NN cord-286607-5i406twr 56 15 , , , cord-286607-5i406twr 56 16 such such JJ cord-286607-5i406twr 56 17 as as IN cord-286607-5i406twr 56 18 the the DT cord-286607-5i406twr 56 19 induction induction NN cord-286607-5i406twr 56 20 of of IN cord-286607-5i406twr 56 21 regulatory regulatory JJ cord-286607-5i406twr 56 22 effector effector NN cord-286607-5i406twr 56 23 CD4 CD4 NNP cord-286607-5i406twr 56 24 + + CC cord-286607-5i406twr 56 25 cells cell NNS cord-286607-5i406twr 56 26 and and CC cord-286607-5i406twr 56 27 production production NN cord-286607-5i406twr 56 28 of of IN cord-286607-5i406twr 56 29 cytokines cytokine NNS cord-286607-5i406twr 56 30 and and CC cord-286607-5i406twr 56 31 antimicrobial antimicrobial JJ cord-286607-5i406twr 56 32 factors factor NNS cord-286607-5i406twr 56 33 , , , cord-286607-5i406twr 56 34 influencing influence VBG cord-286607-5i406twr 56 35 the the DT cord-286607-5i406twr 56 36 individual individual JJ cord-286607-5i406twr 56 37 response response NN cord-286607-5i406twr 56 38 to to IN cord-286607-5i406twr 56 39 various various JJ cord-286607-5i406twr 56 40 environmental environmental JJ cord-286607-5i406twr 56 41 stimuli stimulus NNS cord-286607-5i406twr 56 42 , , , cord-286607-5i406twr 56 43 as as IN cord-286607-5i406twr 56 44 seen see VBN cord-286607-5i406twr 56 45 in in IN cord-286607-5i406twr 56 46 IBD IBD NNP cord-286607-5i406twr 56 47 , , , cord-286607-5i406twr 56 48 Crohn Crohn NNP cord-286607-5i406twr 56 49 's 's POS cord-286607-5i406twr 56 50 disease disease NN cord-286607-5i406twr 56 51 and and CC cord-286607-5i406twr 56 52 ulcerative ulcerative JJ cord-286607-5i406twr 56 53 colitis colitis NN cord-286607-5i406twr 56 54 ( ( -LRB- cord-286607-5i406twr 56 55 32 32 CD cord-286607-5i406twr 56 56 ) ) -RRB- cord-286607-5i406twr 56 57 . . . cord-286607-5i406twr 57 1 In in IN cord-286607-5i406twr 57 2 a a DT cord-286607-5i406twr 57 3 recent recent JJ cord-286607-5i406twr 57 4 work work NN cord-286607-5i406twr 57 5 , , , cord-286607-5i406twr 57 6 Schwiertz Schwiertz NNP cord-286607-5i406twr 57 7 et et NNP cord-286607-5i406twr 57 8 al al NNP cord-286607-5i406twr 57 9 . . NNP cord-286607-5i406twr 57 10 have have VBP cord-286607-5i406twr 57 11 shown show VBN cord-286607-5i406twr 57 12 microbiota microbiota NN cord-286607-5i406twr 57 13 changes change NNS cord-286607-5i406twr 57 14 characterized characterize VBN cord-286607-5i406twr 57 15 by by IN cord-286607-5i406twr 57 16 decreased decrease VBN cord-286607-5i406twr 57 17 numbers number NNS cord-286607-5i406twr 57 18 of of IN cord-286607-5i406twr 57 19 Faecalibacterium Faecalibacterium NNP cord-286607-5i406twr 57 20 praunsitzii praunsitzii NN cord-286607-5i406twr 57 21 and and CC cord-286607-5i406twr 57 22 increased increase VBN cord-286607-5i406twr 57 23 numbers number NNS cord-286607-5i406twr 57 24 of of IN cord-286607-5i406twr 57 25 Escherichia Escherichia NNP cord-286607-5i406twr 57 26 coli coli NNS cord-286607-5i406twr 57 27 in in IN cord-286607-5i406twr 57 28 IBD IBD NNP cord-286607-5i406twr 57 29 ( ( -LRB- cord-286607-5i406twr 57 30 33 33 CD cord-286607-5i406twr 57 31 ) ) -RRB- cord-286607-5i406twr 57 32 . . . cord-286607-5i406twr 58 1 Additionally additionally RB cord-286607-5i406twr 58 2 , , , cord-286607-5i406twr 58 3 in in IN cord-286607-5i406twr 58 4 celiac celiac JJ cord-286607-5i406twr 58 5 disease disease NN cord-286607-5i406twr 58 6 De De NNP cord-286607-5i406twr 58 7 Palma Palma NNP cord-286607-5i406twr 58 8 et et NNP cord-286607-5i406twr 58 9 al al NNP cord-286607-5i406twr 58 10 . . NNP cord-286607-5i406twr 58 11 have have VBP cord-286607-5i406twr 58 12 described describe VBN cord-286607-5i406twr 58 13 a a DT cord-286607-5i406twr 58 14 difference difference NN cord-286607-5i406twr 58 15 in in IN cord-286607-5i406twr 58 16 the the DT cord-286607-5i406twr 58 17 microbiota microbiota NN cord-286607-5i406twr 58 18 composition composition NN cord-286607-5i406twr 58 19 with with IN cord-286607-5i406twr 58 20 a a DT cord-286607-5i406twr 58 21 reduction reduction NN cord-286607-5i406twr 58 22 of of IN cord-286607-5i406twr 58 23 Bifidobacterium bifidobacterium NN cord-286607-5i406twr 58 24 , , , cord-286607-5i406twr 58 25 Clostridium Clostridium NNP cord-286607-5i406twr 58 26 histolyticum histolyticum NN cord-286607-5i406twr 58 27 , , , cord-286607-5i406twr 58 28 Clostridium clostridium NN cord-286607-5i406twr 58 29 lituseburense lituseburense NN cord-286607-5i406twr 58 30 , , , cord-286607-5i406twr 58 31 Faecalibacterium Faecalibacterium NNP cord-286607-5i406twr 58 32 prausnitzii prausnitzii NN cord-286607-5i406twr 58 33 , , , cord-286607-5i406twr 58 34 and and CC cord-286607-5i406twr 58 35 an an DT cord-286607-5i406twr 58 36 abundance abundance NN cord-286607-5i406twr 58 37 of of IN cord-286607-5i406twr 58 38 Bacteroides Bacteroides NNP cord-286607-5i406twr 58 39 and and CC cord-286607-5i406twr 58 40 Prevotella Prevotella NNP cord-286607-5i406twr 58 41 strains strain NNS cord-286607-5i406twr 58 42 ( ( -LRB- cord-286607-5i406twr 58 43 34 34 CD cord-286607-5i406twr 58 44 ) ) -RRB- cord-286607-5i406twr 58 45 . . . cord-286607-5i406twr 59 1 A a DT cord-286607-5i406twr 59 2 significantly significantly RB cord-286607-5i406twr 59 3 higher high JJR cord-286607-5i406twr 59 4 biodiversity biodiversity NN cord-286607-5i406twr 59 5 in in IN cord-286607-5i406twr 59 6 coeliac coeliac JJ cord-286607-5i406twr 59 7 children child NNS cord-286607-5i406twr 59 8 's 's POS cord-286607-5i406twr 59 9 duodenal duodenal JJ cord-286607-5i406twr 59 10 mucosa mucosa NN cord-286607-5i406twr 59 11 was be VBD cord-286607-5i406twr 59 12 demonstrated demonstrate VBN cord-286607-5i406twr 59 13 by by IN cord-286607-5i406twr 59 14 Schippa Schippa NNP cord-286607-5i406twr 59 15 et et FW cord-286607-5i406twr 59 16 al al NNP cord-286607-5i406twr 59 17 . . . cord-286607-5i406twr 60 1 who who WP cord-286607-5i406twr 60 2 also also RB cord-286607-5i406twr 60 3 highlighted highlight VBD cord-286607-5i406twr 60 4 that that IN cord-286607-5i406twr 60 5 the the DT cord-286607-5i406twr 60 6 possible possible JJ cord-286607-5i406twr 60 7 pathophysiological pathophysiological JJ cord-286607-5i406twr 60 8 role role NN cord-286607-5i406twr 60 9 of of IN cord-286607-5i406twr 60 10 such such JJ cord-286607-5i406twr 60 11 microbial microbial JJ cord-286607-5i406twr 60 12 differences difference NNS cord-286607-5i406twr 60 13 needs need VBZ cord-286607-5i406twr 60 14 further further JJ cord-286607-5i406twr 60 15 characterization characterization NN cord-286607-5i406twr 60 16 ( ( -LRB- cord-286607-5i406twr 60 17 35 35 CD cord-286607-5i406twr 60 18 ) ) -RRB- cord-286607-5i406twr 60 19 . . . cord-286607-5i406twr 61 1 In in IN cord-286607-5i406twr 61 2 addition addition NN cord-286607-5i406twr 61 3 , , , cord-286607-5i406twr 61 4 many many JJ cord-286607-5i406twr 61 5 immune immune JJ cord-286607-5i406twr 61 6 phenomena phenomenon NNS cord-286607-5i406twr 61 7 were be VBD cord-286607-5i406twr 61 8 shown show VBN cord-286607-5i406twr 61 9 to to TO cord-286607-5i406twr 61 10 deteriorate deteriorate VB cord-286607-5i406twr 61 11 under under IN cord-286607-5i406twr 61 12 the the DT cord-286607-5i406twr 61 13 effect effect NN cord-286607-5i406twr 61 14 of of IN cord-286607-5i406twr 61 15 changes change NNS cord-286607-5i406twr 61 16 in in IN cord-286607-5i406twr 61 17 the the DT cord-286607-5i406twr 61 18 microbiota microbiota NN cord-286607-5i406twr 61 19 , , , cord-286607-5i406twr 61 20 as as IN cord-286607-5i406twr 61 21 revealed reveal VBN cord-286607-5i406twr 61 22 by by IN cord-286607-5i406twr 61 23 the the DT cord-286607-5i406twr 61 24 correlation correlation NN cord-286607-5i406twr 61 25 among among IN cord-286607-5i406twr 61 26 intestinal intestinal JJ cord-286607-5i406twr 61 27 bacterial bacterial JJ cord-286607-5i406twr 61 28 overgrowth overgrowth NN cord-286607-5i406twr 61 29 , , , cord-286607-5i406twr 61 30 increased increase VBN cord-286607-5i406twr 61 31 permeability permeability NN cord-286607-5i406twr 61 32 , , , cord-286607-5i406twr 61 33 and and CC cord-286607-5i406twr 61 34 development development NN cord-286607-5i406twr 61 35 of of IN cord-286607-5i406twr 61 36 non non JJ cord-286607-5i406twr 61 37 - - JJ cord-286607-5i406twr 61 38 alcoholic alcoholic JJ cord-286607-5i406twr 61 39 steatohepatitis steatohepatitis NN cord-286607-5i406twr 61 40 ( ( -LRB- cord-286607-5i406twr 61 41 36 36 CD cord-286607-5i406twr 61 42 ) ) -RRB- cord-286607-5i406twr 61 43 . . . cord-286607-5i406twr 62 1 Much much JJ cord-286607-5i406twr 62 2 interest interest NN cord-286607-5i406twr 62 3 has have VBZ cord-286607-5i406twr 62 4 also also RB cord-286607-5i406twr 62 5 been be VBN cord-286607-5i406twr 62 6 paid pay VBN cord-286607-5i406twr 62 7 to to IN cord-286607-5i406twr 62 8 the the DT cord-286607-5i406twr 62 9 role role NN cord-286607-5i406twr 62 10 of of IN cord-286607-5i406twr 62 11 the the DT cord-286607-5i406twr 62 12 microbiome microbiome NN cord-286607-5i406twr 62 13 in in IN cord-286607-5i406twr 62 14 the the DT cord-286607-5i406twr 62 15 development development NN cord-286607-5i406twr 62 16 of of IN cord-286607-5i406twr 62 17 " " `` cord-286607-5i406twr 62 18 sterile sterile JJ cord-286607-5i406twr 62 19 " " '' cord-286607-5i406twr 62 20 inflammation inflammation NN cord-286607-5i406twr 62 21 , , , cord-286607-5i406twr 62 22 and and CC cord-286607-5i406twr 62 23 recent recent JJ cord-286607-5i406twr 62 24 studies study NNS cord-286607-5i406twr 62 25 have have VBP cord-286607-5i406twr 62 26 proved prove VBN cord-286607-5i406twr 62 27 that that IN cord-286607-5i406twr 62 28 either either DT cord-286607-5i406twr 62 29 depletion depletion NN cord-286607-5i406twr 62 30 of of IN cord-286607-5i406twr 62 31 the the DT cord-286607-5i406twr 62 32 microbiota microbiota NN cord-286607-5i406twr 62 33 or or CC cord-286607-5i406twr 62 34 changes change NNS cord-286607-5i406twr 62 35 in in IN cord-286607-5i406twr 62 36 the the DT cord-286607-5i406twr 62 37 diet diet NN cord-286607-5i406twr 62 38 and and CC cord-286607-5i406twr 62 39 in in IN cord-286607-5i406twr 62 40 the the DT cord-286607-5i406twr 62 41 gut gut NN cord-286607-5i406twr 62 42 microbiome microbiome NN cord-286607-5i406twr 62 43 might may MD cord-286607-5i406twr 62 44 lead lead VB cord-286607-5i406twr 62 45 to to IN cord-286607-5i406twr 62 46 the the DT cord-286607-5i406twr 62 47 improvement improvement NN cord-286607-5i406twr 62 48 of of IN cord-286607-5i406twr 62 49 inflammasome inflammasome NN cord-286607-5i406twr 62 50 - - HYPH cord-286607-5i406twr 62 51 mediated mediate VBN cord-286607-5i406twr 62 52 manifestations manifestation NNS cord-286607-5i406twr 62 53 of of IN cord-286607-5i406twr 62 54 autoinflammatory autoinflammatory JJ cord-286607-5i406twr 62 55 disorders disorder NNS cord-286607-5i406twr 62 56 , , , cord-286607-5i406twr 62 57 which which WDT cord-286607-5i406twr 62 58 are be VBP cord-286607-5i406twr 62 59 caused cause VBN cord-286607-5i406twr 62 60 by by IN cord-286607-5i406twr 62 61 dysregulation dysregulation NN cord-286607-5i406twr 62 62 of of IN cord-286607-5i406twr 62 63 specific specific JJ cord-286607-5i406twr 62 64 components component NNS cord-286607-5i406twr 62 65 of of IN cord-286607-5i406twr 62 66 innate innate JJ cord-286607-5i406twr 62 67 immunity immunity NN cord-286607-5i406twr 62 68 ( ( -LRB- cord-286607-5i406twr 62 69 37 37 CD cord-286607-5i406twr 62 70 ) ) -RRB- cord-286607-5i406twr 62 71 . . . cord-286607-5i406twr 63 1 These these DT cord-286607-5i406twr 63 2 diseases disease NNS cord-286607-5i406twr 63 3 can can MD cord-286607-5i406twr 63 4 be be VB cord-286607-5i406twr 63 5 subdivided subdivide VBN cord-286607-5i406twr 63 6 into into IN cord-286607-5i406twr 63 7 monogenic monogenic NNP cord-286607-5i406twr 63 8 and and CC cord-286607-5i406twr 63 9 multifactorial multifactorial JJ cord-286607-5i406twr 63 10 disorders disorder NNS cord-286607-5i406twr 63 11 , , , cord-286607-5i406twr 63 12 with with IN cord-286607-5i406twr 63 13 the the DT cord-286607-5i406twr 63 14 former former JJ cord-286607-5i406twr 63 15 being being NN cord-286607-5i406twr 63 16 caused cause VBN cord-286607-5i406twr 63 17 by by IN cord-286607-5i406twr 63 18 mutations mutation NNS cord-286607-5i406twr 63 19 of of IN cord-286607-5i406twr 63 20 genes gene NNS cord-286607-5i406twr 63 21 involved involve VBN cord-286607-5i406twr 63 22 in in IN cord-286607-5i406twr 63 23 the the DT cord-286607-5i406twr 63 24 regulation regulation NN cord-286607-5i406twr 63 25 of of IN cord-286607-5i406twr 63 26 the the DT cord-286607-5i406twr 63 27 innate innate JJ cord-286607-5i406twr 63 28 immune immune JJ cord-286607-5i406twr 63 29 system system NN cord-286607-5i406twr 63 30 and and CC cord-286607-5i406twr 63 31 the the DT cord-286607-5i406twr 63 32 latter latter JJ cord-286607-5i406twr 63 33 by by IN cord-286607-5i406twr 63 34 a a DT cord-286607-5i406twr 63 35 combination combination NN cord-286607-5i406twr 63 36 of of IN cord-286607-5i406twr 63 37 genetic genetic JJ cord-286607-5i406twr 63 38 background background NN cord-286607-5i406twr 63 39 and and CC cord-286607-5i406twr 63 40 environmental environmental JJ cord-286607-5i406twr 63 41 factors factor NNS cord-286607-5i406twr 63 42 ( ( -LRB- cord-286607-5i406twr 63 43 38 38 CD cord-286607-5i406twr 63 44 ) ) -RRB- cord-286607-5i406twr 63 45 ( ( -LRB- cord-286607-5i406twr 63 46 39 39 CD cord-286607-5i406twr 63 47 ) ) -RRB- cord-286607-5i406twr 63 48 ( ( -LRB- cord-286607-5i406twr 63 49 40 40 CD cord-286607-5i406twr 63 50 ) ) -RRB- cord-286607-5i406twr 63 51 . . . cord-286607-5i406twr 64 1 Given give VBN cord-286607-5i406twr 64 2 the the DT cord-286607-5i406twr 64 3 evidence evidence NN cord-286607-5i406twr 64 4 for for IN cord-286607-5i406twr 64 5 the the DT cord-286607-5i406twr 64 6 role role NN cord-286607-5i406twr 64 7 of of IN cord-286607-5i406twr 64 8 the the DT cord-286607-5i406twr 64 9 intestinal intestinal JJ cord-286607-5i406twr 64 10 microbiota microbiota NN cord-286607-5i406twr 64 11 in in IN cord-286607-5i406twr 64 12 the the DT cord-286607-5i406twr 64 13 inflammatory inflammatory JJ cord-286607-5i406twr 64 14 state state NN cord-286607-5i406twr 64 15 of of IN cord-286607-5i406twr 64 16 IBD IBD NNP cord-286607-5i406twr 64 17 , , , cord-286607-5i406twr 64 18 atopic atopic JJ cord-286607-5i406twr 64 19 diseases disease NNS cord-286607-5i406twr 64 20 and and CC cord-286607-5i406twr 64 21 numerous numerous JJ cord-286607-5i406twr 64 22 non non JJ cord-286607-5i406twr 64 23 - - JJ cord-286607-5i406twr 64 24 infectious infectious JJ cord-286607-5i406twr 64 25 diseases disease NNS cord-286607-5i406twr 64 26 , , , cord-286607-5i406twr 64 27 it -PRON- PRP cord-286607-5i406twr 64 28 has have VBZ cord-286607-5i406twr 64 29 been be VBN cord-286607-5i406twr 64 30 speculated speculate VBN cord-286607-5i406twr 64 31 that that IN cord-286607-5i406twr 64 32 intestinal intestinal JJ cord-286607-5i406twr 64 33 microbial microbial JJ cord-286607-5i406twr 64 34 agents agent NNS cord-286607-5i406twr 64 35 might may MD cord-286607-5i406twr 64 36 also also RB cord-286607-5i406twr 64 37 play play VB cord-286607-5i406twr 64 38 a a DT cord-286607-5i406twr 64 39 trigger trigger NN cord-286607-5i406twr 64 40 role role NN cord-286607-5i406twr 64 41 in in IN cord-286607-5i406twr 64 42 the the DT cord-286607-5i406twr 64 43 development development NN cord-286607-5i406twr 64 44 of of IN cord-286607-5i406twr 64 45 other other JJ cord-286607-5i406twr 64 46 inflammatory inflammatory JJ cord-286607-5i406twr 64 47 disorders disorder NNS cord-286607-5i406twr 64 48 which which WDT cord-286607-5i406twr 64 49 do do VBP cord-286607-5i406twr 64 50 not not RB cord-286607-5i406twr 64 51 have have VB cord-286607-5i406twr 64 52 a a DT cord-286607-5i406twr 64 53 clearly clearly RB cord-286607-5i406twr 64 54 defined define VBN cord-286607-5i406twr 64 55 etiology etiology NN cord-286607-5i406twr 64 56 , , , cord-286607-5i406twr 64 57 such such JJ cord-286607-5i406twr 64 58 as as IN cord-286607-5i406twr 64 59 KS KS NNP cord-286607-5i406twr 64 60 . . . cord-286607-5i406twr 65 1 The the DT cord-286607-5i406twr 65 2 etiology etiology NN cord-286607-5i406twr 65 3 of of IN cord-286607-5i406twr 65 4 KS KS NNP cord-286607-5i406twr 65 5 remains remain VBZ cord-286607-5i406twr 65 6 obscure obscure JJ cord-286607-5i406twr 65 7 , , , cord-286607-5i406twr 65 8 although although IN cord-286607-5i406twr 65 9 clinical clinical JJ cord-286607-5i406twr 65 10 and and CC cord-286607-5i406twr 65 11 epidemiological epidemiological JJ cord-286607-5i406twr 65 12 features feature NNS cord-286607-5i406twr 65 13 suggest suggest VBP cord-286607-5i406twr 65 14 a a DT cord-286607-5i406twr 65 15 primary primary JJ cord-286607-5i406twr 65 16 infectious infectious JJ cord-286607-5i406twr 65 17 cause cause NN cord-286607-5i406twr 65 18 . . . cord-286607-5i406twr 66 1 Indeed indeed RB cord-286607-5i406twr 66 2 , , , cord-286607-5i406twr 66 3 a a DT cord-286607-5i406twr 66 4 self self NN cord-286607-5i406twr 66 5 - - HYPH cord-286607-5i406twr 66 6 limited limit VBN cord-286607-5i406twr 66 7 and and CC cord-286607-5i406twr 66 8 generally generally RB cord-286607-5i406twr 66 9 nonrecurring nonrecurre VBG cord-286607-5i406twr 66 10 illness illness NN cord-286607-5i406twr 66 11 that that WDT cord-286607-5i406twr 66 12 manifests manifest VBZ cord-286607-5i406twr 66 13 itself -PRON- PRP cord-286607-5i406twr 66 14 by by IN cord-286607-5i406twr 66 15 fever fever NN cord-286607-5i406twr 66 16 , , , cord-286607-5i406twr 66 17 rash rash JJ cord-286607-5i406twr 66 18 , , , cord-286607-5i406twr 66 19 mucositis mucositis NNP cord-286607-5i406twr 66 20 , , , cord-286607-5i406twr 66 21 conjunctival conjunctival NN cord-286607-5i406twr 66 22 injection injection NN cord-286607-5i406twr 66 23 , , , cord-286607-5i406twr 66 24 and and CC cord-286607-5i406twr 66 25 cervical cervical JJ cord-286607-5i406twr 66 26 adenopathy adenopathy NN cord-286607-5i406twr 66 27 fits fit VBZ cord-286607-5i406twr 66 28 well well RB cord-286607-5i406twr 66 29 with with IN cord-286607-5i406twr 66 30 an an DT cord-286607-5i406twr 66 31 infection infection NN cord-286607-5i406twr 66 32 . . . cord-286607-5i406twr 67 1 More more RBR cord-286607-5i406twr 67 2 precisely precisely RB cord-286607-5i406twr 67 3 , , , cord-286607-5i406twr 67 4 clinical clinical JJ cord-286607-5i406twr 67 5 features feature NNS cord-286607-5i406twr 67 6 of of IN cord-286607-5i406twr 67 7 KS KS NNP cord-286607-5i406twr 67 8 resemble resemble VB cord-286607-5i406twr 67 9 some some DT cord-286607-5i406twr 67 10 peculiar peculiar JJ cord-286607-5i406twr 67 11 infectious infectious JJ cord-286607-5i406twr 67 12 diseases disease NNS cord-286607-5i406twr 67 13 , , , cord-286607-5i406twr 67 14 such such JJ cord-286607-5i406twr 67 15 as as IN cord-286607-5i406twr 67 16 streptococcal streptococcal JJ cord-286607-5i406twr 67 17 infections infection NNS cord-286607-5i406twr 67 18 , , , cord-286607-5i406twr 67 19 staphylococcal staphylococcal JJ cord-286607-5i406twr 67 20 toxic toxic JJ cord-286607-5i406twr 67 21 shock shock NN cord-286607-5i406twr 67 22 syndrome syndrome NN cord-286607-5i406twr 67 23 , , , cord-286607-5i406twr 67 24 and and CC cord-286607-5i406twr 67 25 atypical atypical JJ cord-286607-5i406twr 67 26 measles measle NNS cord-286607-5i406twr 67 27 ( ( -LRB- cord-286607-5i406twr 67 28 12 12 CD cord-286607-5i406twr 67 29 , , , cord-286607-5i406twr 67 30 13 13 CD cord-286607-5i406twr 67 31 ) ) -RRB- cord-286607-5i406twr 67 32 . . . cord-286607-5i406twr 68 1 Additionally additionally RB cord-286607-5i406twr 68 2 , , , cord-286607-5i406twr 68 3 age age NN cord-286607-5i406twr 68 4 distribution distribution NN cord-286607-5i406twr 68 5 , , , cord-286607-5i406twr 68 6 winter winter NN cord-286607-5i406twr 68 7 - - HYPH cord-286607-5i406twr 68 8 spring spring NN cord-286607-5i406twr 68 9 seasonality seasonality NN cord-286607-5i406twr 68 10 , , , cord-286607-5i406twr 68 11 high high JJ cord-286607-5i406twr 68 12 rates rate NNS cord-286607-5i406twr 68 13 of of IN cord-286607-5i406twr 68 14 KS KS NNP cord-286607-5i406twr 68 15 in in IN cord-286607-5i406twr 68 16 siblings sibling NNS cord-286607-5i406twr 68 17 , , , cord-286607-5i406twr 68 18 and and CC cord-286607-5i406twr 68 19 occurrence occurrence NN cord-286607-5i406twr 68 20 of of IN cord-286607-5i406twr 68 21 community community NN cord-286607-5i406twr 68 22 outbreaks outbreak NNS cord-286607-5i406twr 68 23 are be VBP cord-286607-5i406twr 68 24 suggestive suggestive JJ cord-286607-5i406twr 68 25 of of IN cord-286607-5i406twr 68 26 a a DT cord-286607-5i406twr 68 27 transmissible transmissible JJ cord-286607-5i406twr 68 28 childhood childhood NN cord-286607-5i406twr 68 29 disease disease NN cord-286607-5i406twr 68 30 , , , cord-286607-5i406twr 68 31 though though IN cord-286607-5i406twr 68 32 many many JJ cord-286607-5i406twr 68 33 efforts effort NNS cord-286607-5i406twr 68 34 with with IN cord-286607-5i406twr 68 35 conventional conventional JJ cord-286607-5i406twr 68 36 bacterial bacterial JJ cord-286607-5i406twr 68 37 and and CC cord-286607-5i406twr 68 38 viral viral JJ cord-286607-5i406twr 68 39 cultures culture NNS cord-286607-5i406twr 68 40 and and CC cord-286607-5i406twr 68 41 serological serological JJ cord-286607-5i406twr 68 42 methods method NNS cord-286607-5i406twr 68 43 as as RB cord-286607-5i406twr 68 44 well well RB cord-286607-5i406twr 68 45 as as IN cord-286607-5i406twr 68 46 animal animal NN cord-286607-5i406twr 68 47 inoculation inoculation NN cord-286607-5i406twr 68 48 studies study NNS cord-286607-5i406twr 68 49 have have VBP cord-286607-5i406twr 68 50 failed fail VBN cord-286607-5i406twr 68 51 to to TO cord-286607-5i406twr 68 52 identify identify VB cord-286607-5i406twr 68 53 a a DT cord-286607-5i406twr 68 54 final final JJ cord-286607-5i406twr 68 55 unique unique JJ cord-286607-5i406twr 68 56 infectious infectious JJ cord-286607-5i406twr 68 57 agent agent NN cord-286607-5i406twr 68 58 of of IN cord-286607-5i406twr 68 59 KS KS NNP cord-286607-5i406twr 68 60 ( ( -LRB- cord-286607-5i406twr 68 61 41 41 CD cord-286607-5i406twr 68 62 ) ) -RRB- cord-286607-5i406twr 68 63 . . . cord-286607-5i406twr 69 1 Reported report VBN cord-286607-5i406twr 69 2 non non JJ cord-286607-5i406twr 69 3 - - JJ cord-286607-5i406twr 69 4 infectious infectious JJ cord-286607-5i406twr 69 5 factors factor NNS cord-286607-5i406twr 69 6 associated associate VBN cord-286607-5i406twr 69 7 with with IN cord-286607-5i406twr 69 8 KS KS NNP cord-286607-5i406twr 69 9 include include VBP cord-286607-5i406twr 69 10 carpet carpet NN cord-286607-5i406twr 69 11 shampoo shampoo NN cord-286607-5i406twr 69 12 , , , cord-286607-5i406twr 69 13 preexisting preexisting JJ cord-286607-5i406twr 69 14 eczema eczema NN cord-286607-5i406twr 69 15 , , , cord-286607-5i406twr 69 16 environmental environmental JJ cord-286607-5i406twr 69 17 pollution pollution NN cord-286607-5i406twr 69 18 , , , cord-286607-5i406twr 69 19 and and CC cord-286607-5i406twr 69 20 house house NN cord-286607-5i406twr 69 21 dust dust NN cord-286607-5i406twr 69 22 mites mites NNPS cord-286607-5i406twr 69 23 ( ( -LRB- cord-286607-5i406twr 69 24 42 42 CD cord-286607-5i406twr 69 25 ) ) -RRB- cord-286607-5i406twr 69 26 . . . cord-286607-5i406twr 70 1 The the DT cord-286607-5i406twr 70 2 higher high JJR cord-286607-5i406twr 70 3 incidence incidence NN cord-286607-5i406twr 70 4 of of IN cord-286607-5i406twr 70 5 KS KS NNP cord-286607-5i406twr 70 6 in in IN cord-286607-5i406twr 70 7 Asian asian JJ cord-286607-5i406twr 70 8 populations population NNS cord-286607-5i406twr 70 9 , , , cord-286607-5i406twr 70 10 presence presence NN cord-286607-5i406twr 70 11 of of IN cord-286607-5i406twr 70 12 familial familial JJ cord-286607-5i406twr 70 13 clustering clustering NN cord-286607-5i406twr 70 14 , , , cord-286607-5i406twr 70 15 and and CC cord-286607-5i406twr 70 16 elevated elevated JJ cord-286607-5i406twr 70 17 risk risk NN cord-286607-5i406twr 70 18 of of IN cord-286607-5i406twr 70 19 recurrence recurrence NN cord-286607-5i406twr 70 20 vs. vs. IN cord-286607-5i406twr 70 21 the the DT cord-286607-5i406twr 70 22 risk risk NN cord-286607-5i406twr 70 23 of of IN cord-286607-5i406twr 70 24 a a DT cord-286607-5i406twr 70 25 first first JJ cord-286607-5i406twr 70 26 episode episode NN cord-286607-5i406twr 70 27 in in IN cord-286607-5i406twr 70 28 KS KS NNP cord-286607-5i406twr 70 29 - - HYPH cord-286607-5i406twr 70 30 naïve naïve JJ cord-286607-5i406twr 70 31 children child NNS cord-286607-5i406twr 70 32 are be VBP cord-286607-5i406twr 70 33 all all DT cord-286607-5i406twr 70 34 strong strong JJ cord-286607-5i406twr 70 35 evidence evidence NN cord-286607-5i406twr 70 36 of of IN cord-286607-5i406twr 70 37 a a DT cord-286607-5i406twr 70 38 genetic genetic JJ cord-286607-5i406twr 70 39 contribution contribution NN cord-286607-5i406twr 70 40 to to IN cord-286607-5i406twr 70 41 KS KS NNP cord-286607-5i406twr 70 42 susceptibility susceptibility NN cord-286607-5i406twr 70 43 , , , cord-286607-5i406twr 70 44 probably probably RB cord-286607-5i406twr 70 45 in in IN cord-286607-5i406twr 70 46 association association NN cord-286607-5i406twr 70 47 with with IN cord-286607-5i406twr 70 48 an an DT cord-286607-5i406twr 70 49 infectious infectious JJ cord-286607-5i406twr 70 50 trigger trigger NN cord-286607-5i406twr 70 51 ( ( -LRB- cord-286607-5i406twr 70 52 43 43 CD cord-286607-5i406twr 70 53 , , , cord-286607-5i406twr 70 54 44 44 CD cord-286607-5i406twr 70 55 ) ) -RRB- cord-286607-5i406twr 70 56 . . . cord-286607-5i406twr 71 1 However however RB cord-286607-5i406twr 71 2 , , , cord-286607-5i406twr 71 3 KS KS NNP cord-286607-5i406twr 71 4 does do VBZ cord-286607-5i406twr 71 5 not not RB cord-286607-5i406twr 71 6 appear appear VB cord-286607-5i406twr 71 7 easily easily RB cord-286607-5i406twr 71 8 transmittable transmittable JJ cord-286607-5i406twr 71 9 and and CC cord-286607-5i406twr 71 10 does do VBZ cord-286607-5i406twr 71 11 not not RB cord-286607-5i406twr 71 12 respond respond VB cord-286607-5i406twr 71 13 to to IN cord-286607-5i406twr 71 14 any any DT cord-286607-5i406twr 71 15 antibiotics antibiotic NNS cord-286607-5i406twr 71 16 : : : cord-286607-5i406twr 71 17 these these DT cord-286607-5i406twr 71 18 characteristics characteristic NNS cord-286607-5i406twr 71 19 should should MD cord-286607-5i406twr 71 20 contradict contradict VB cord-286607-5i406twr 71 21 a a DT cord-286607-5i406twr 71 22 primitively primitively RB cord-286607-5i406twr 71 23 infectious infectious JJ cord-286607-5i406twr 71 24 pathogenesis pathogenesis NN cord-286607-5i406twr 71 25 of of IN cord-286607-5i406twr 71 26 the the DT cord-286607-5i406twr 71 27 illness illness NN cord-286607-5i406twr 71 28 . . . cord-286607-5i406twr 72 1 The the DT cord-286607-5i406twr 72 2 most most RBS cord-286607-5i406twr 72 3 current current JJ cord-286607-5i406twr 72 4 theory theory NN cord-286607-5i406twr 72 5 about about IN cord-286607-5i406twr 72 6 the the DT cord-286607-5i406twr 72 7 pathogenesis pathogenesis NN cord-286607-5i406twr 72 8 of of IN cord-286607-5i406twr 72 9 KS KS NNP cord-286607-5i406twr 72 10 is be VBZ cord-286607-5i406twr 72 11 that that IN cord-286607-5i406twr 72 12 the the DT cord-286607-5i406twr 72 13 disease disease NN cord-286607-5i406twr 72 14 results result VBZ cord-286607-5i406twr 72 15 from from IN cord-286607-5i406twr 72 16 an an DT cord-286607-5i406twr 72 17 exaggerated exaggerated JJ cord-286607-5i406twr 72 18 immune immune JJ cord-286607-5i406twr 72 19 response response NN cord-286607-5i406twr 72 20 toward toward IN cord-286607-5i406twr 72 21 environmental environmental JJ cord-286607-5i406twr 72 22 stimuli stimulus NNS cord-286607-5i406twr 72 23 occurring occur VBG cord-286607-5i406twr 72 24 in in IN cord-286607-5i406twr 72 25 a a DT cord-286607-5i406twr 72 26 genetically genetically RB cord-286607-5i406twr 72 27 susceptible susceptible JJ cord-286607-5i406twr 72 28 child child NN cord-286607-5i406twr 72 29 ( ( -LRB- cord-286607-5i406twr 72 30 13 13 CD cord-286607-5i406twr 72 31 ) ) -RRB- cord-286607-5i406twr 72 32 . . . cord-286607-5i406twr 73 1 The the DT cord-286607-5i406twr 73 2 prominent prominent JJ cord-286607-5i406twr 73 3 role role NN cord-286607-5i406twr 73 4 played play VBN cord-286607-5i406twr 73 5 by by IN cord-286607-5i406twr 73 6 the the DT cord-286607-5i406twr 73 7 immune immune JJ cord-286607-5i406twr 73 8 system system NN cord-286607-5i406twr 73 9 in in IN cord-286607-5i406twr 73 10 KS KS NNP cord-286607-5i406twr 73 11 is be VBZ cord-286607-5i406twr 73 12 confirmed confirm VBN cord-286607-5i406twr 73 13 by by IN cord-286607-5i406twr 73 14 the the DT cord-286607-5i406twr 73 15 high high JJ cord-286607-5i406twr 73 16 number number NN cord-286607-5i406twr 73 17 of of IN cord-286607-5i406twr 73 18 studies study NNS cord-286607-5i406twr 73 19 revealing reveal VBG cord-286607-5i406twr 73 20 the the DT cord-286607-5i406twr 73 21 activation activation NN cord-286607-5i406twr 73 22 of of IN cord-286607-5i406twr 73 23 neutrophils neutrophil NNS cord-286607-5i406twr 73 24 and and CC cord-286607-5i406twr 73 25 multiple multiple JJ cord-286607-5i406twr 73 26 immune immune JJ cord-286607-5i406twr 73 27 cells cell NNS cord-286607-5i406twr 73 28 with with IN cord-286607-5i406twr 73 29 overproduction overproduction NN cord-286607-5i406twr 73 30 of of IN cord-286607-5i406twr 73 31 pro pro JJ cord-286607-5i406twr 73 32 - - JJ cord-286607-5i406twr 73 33 inflammatory inflammatory JJ cord-286607-5i406twr 73 34 cytokines cytokine NNS cord-286607-5i406twr 73 35 , , , cord-286607-5i406twr 73 36 including include VBG cord-286607-5i406twr 73 37 tumor tumor NN cord-286607-5i406twr 73 38 necrosis necrosis NN cord-286607-5i406twr 73 39 factor factor NN cord-286607-5i406twr 73 40 ( ( -LRB- cord-286607-5i406twr 73 41 TNF)-α TNF)-α NNP cord-286607-5i406twr 73 42 ( ( -LRB- cord-286607-5i406twr 73 43 45 45 CD cord-286607-5i406twr 73 44 , , , cord-286607-5i406twr 73 45 46 46 CD cord-286607-5i406twr 73 46 ) ) -RRB- cord-286607-5i406twr 73 47 . . . cord-286607-5i406twr 74 1 Manlhiot Manlhiot NNP cord-286607-5i406twr 74 2 et et NNP cord-286607-5i406twr 74 3 al al NNP cord-286607-5i406twr 74 4 . . . cord-286607-5i406twr 75 1 have have VBP cord-286607-5i406twr 75 2 very very RB cord-286607-5i406twr 75 3 recently recently RB cord-286607-5i406twr 75 4 proposed propose VBN cord-286607-5i406twr 75 5 a a DT cord-286607-5i406twr 75 6 new new JJ cord-286607-5i406twr 75 7 pathogenetic pathogenetic JJ cord-286607-5i406twr 75 8 model model NN cord-286607-5i406twr 75 9 of of IN cord-286607-5i406twr 75 10 KS KS NNP cord-286607-5i406twr 75 11 in in IN cord-286607-5i406twr 75 12 which which WDT cord-286607-5i406twr 75 13 the the DT cord-286607-5i406twr 75 14 disease disease NN cord-286607-5i406twr 75 15 risk risk NN cord-286607-5i406twr 75 16 is be VBZ cord-286607-5i406twr 75 17 determined determine VBN cord-286607-5i406twr 75 18 by by IN cord-286607-5i406twr 75 19 concurrent concurrent JJ cord-286607-5i406twr 75 20 interacting interact VBG cord-286607-5i406twr 75 21 processes process NNS cord-286607-5i406twr 75 22 : : : cord-286607-5i406twr 75 23 genetic genetic JJ cord-286607-5i406twr 75 24 susceptibility susceptibility NN cord-286607-5i406twr 75 25 , , , cord-286607-5i406twr 75 26 habitual habitual JJ cord-286607-5i406twr 75 27 exposure exposure NN cord-286607-5i406twr 75 28 to to IN cord-286607-5i406twr 75 29 allergens allergen NNS cord-286607-5i406twr 75 30 , , , cord-286607-5i406twr 75 31 atmospheric atmospheric JJ cord-286607-5i406twr 75 32 biological biological JJ cord-286607-5i406twr 75 33 particles particle NNS cord-286607-5i406twr 75 34 , , , cord-286607-5i406twr 75 35 and and CC cord-286607-5i406twr 75 36 infectious infectious JJ cord-286607-5i406twr 75 37 agents agent NNS cord-286607-5i406twr 75 38 ( ( -LRB- cord-286607-5i406twr 75 39 47 47 CD cord-286607-5i406twr 75 40 ) ) -RRB- cord-286607-5i406twr 75 41 . . . cord-286607-5i406twr 76 1 A a DT cord-286607-5i406twr 76 2 study study NN cord-286607-5i406twr 76 3 exploring explore VBG cord-286607-5i406twr 76 4 the the DT cord-286607-5i406twr 76 5 immune immune JJ cord-286607-5i406twr 76 6 responses response NNS cord-286607-5i406twr 76 7 during during IN cord-286607-5i406twr 76 8 the the DT cord-286607-5i406twr 76 9 acute acute JJ cord-286607-5i406twr 76 10 phase phase NN cord-286607-5i406twr 76 11 of of IN cord-286607-5i406twr 76 12 KS KS NNP cord-286607-5i406twr 76 13 showed show VBD cord-286607-5i406twr 76 14 increased increase VBN cord-286607-5i406twr 76 15 levels level NNS cord-286607-5i406twr 76 16 of of IN cord-286607-5i406twr 76 17 lipopolysaccharide lipopolysaccharide NN cord-286607-5i406twr 76 18 ( ( -LRB- cord-286607-5i406twr 76 19 LPS LPS NNP cord-286607-5i406twr 76 20 ) ) -RRB- cord-286607-5i406twr 76 21 bound bind VBN cord-286607-5i406twr 76 22 to to IN cord-286607-5i406twr 76 23 the the DT cord-286607-5i406twr 76 24 surfaces surface NNS cord-286607-5i406twr 76 25 of of IN cord-286607-5i406twr 76 26 circulating circulate VBG cord-286607-5i406twr 76 27 neutrophils neutrophil NNS cord-286607-5i406twr 76 28 via via IN cord-286607-5i406twr 76 29 CD14 CD14 NNP cord-286607-5i406twr 76 30 receptor receptor NN cord-286607-5i406twr 76 31 and and CC cord-286607-5i406twr 76 32 found find VBD cord-286607-5i406twr 76 33 markedly markedly RB cord-286607-5i406twr 76 34 increased increase VBN cord-286607-5i406twr 76 35 levels level NNS cord-286607-5i406twr 76 36 of of IN cord-286607-5i406twr 76 37 the the DT cord-286607-5i406twr 76 38 soluble soluble JJ cord-286607-5i406twr 76 39 CD14 CD14 NNP cord-286607-5i406twr 76 40 in in IN cord-286607-5i406twr 76 41 the the DT cord-286607-5i406twr 76 42 plasma plasma NN cord-286607-5i406twr 76 43 ( ( -LRB- cord-286607-5i406twr 76 44 48 48 CD cord-286607-5i406twr 76 45 ) ) -RRB- cord-286607-5i406twr 76 46 . . . cord-286607-5i406twr 77 1 Furthermore furthermore RB cord-286607-5i406twr 77 2 , , , cord-286607-5i406twr 77 3 Chen Chen NNP cord-286607-5i406twr 77 4 et et NNP cord-286607-5i406twr 77 5 al al NNP cord-286607-5i406twr 77 6 . . . cord-286607-5i406twr 78 1 ( ( -LRB- cord-286607-5i406twr 78 2 49 49 CD cord-286607-5i406twr 78 3 ) ) -RRB- cord-286607-5i406twr 78 4 demonstrated demonstrate VBD cord-286607-5i406twr 78 5 that that IN cord-286607-5i406twr 78 6 NLRP3 NLRP3 NNP cord-286607-5i406twr 78 7 inflammasome inflammasome NNP cord-286607-5i406twr 78 8 activation activation NN cord-286607-5i406twr 78 9 is be VBZ cord-286607-5i406twr 78 10 associated associate VBN cord-286607-5i406twr 78 11 with with IN cord-286607-5i406twr 78 12 the the DT cord-286607-5i406twr 78 13 development development NN cord-286607-5i406twr 78 14 of of IN cord-286607-5i406twr 78 15 coronary coronary JJ cord-286607-5i406twr 78 16 arteritis arteritis NN cord-286607-5i406twr 78 17 in in IN cord-286607-5i406twr 78 18 a a DT cord-286607-5i406twr 78 19 mouse mouse NN cord-286607-5i406twr 78 20 model model NN cord-286607-5i406twr 78 21 of of IN cord-286607-5i406twr 78 22 KS KS NNP cord-286607-5i406twr 78 23 , , , cord-286607-5i406twr 78 24 and and CC cord-286607-5i406twr 78 25 that that DT cord-286607-5i406twr 78 26 infusion infusion NN cord-286607-5i406twr 78 27 of of IN cord-286607-5i406twr 78 28 visfatin visfatin NNP cord-286607-5i406twr 78 29 , , , cord-286607-5i406twr 78 30 a a DT cord-286607-5i406twr 78 31 major major JJ cord-286607-5i406twr 78 32 injurious injurious JJ cord-286607-5i406twr 78 33 adipokine adipokine NN cord-286607-5i406twr 78 34 , , , cord-286607-5i406twr 78 35 can can MD cord-286607-5i406twr 78 36 activate activate VB cord-286607-5i406twr 78 37 NLRP3 NLRP3 NNP cord-286607-5i406twr 78 38 inflammasome inflammasome NN cord-286607-5i406twr 78 39 and and CC cord-286607-5i406twr 78 40 increase increase VB cord-286607-5i406twr 78 41 interleukin interleukin NN cord-286607-5i406twr 78 42 ( ( -LRB- cord-286607-5i406twr 78 43 IL)-1 IL)-1 `` cord-286607-5i406twr 78 44 production production NN cord-286607-5i406twr 78 45 , , , cord-286607-5i406twr 78 46 leading lead VBG cord-286607-5i406twr 78 47 to to IN cord-286607-5i406twr 78 48 enhanced enhanced JJ cord-286607-5i406twr 78 49 endothelial endothelial JJ cord-286607-5i406twr 78 50 dysfunction dysfunction NN cord-286607-5i406twr 78 51 . . . cord-286607-5i406twr 79 1 These these DT cord-286607-5i406twr 79 2 novel novel JJ cord-286607-5i406twr 79 3 molecular molecular JJ cord-286607-5i406twr 79 4 mechanisms mechanism NNS cord-286607-5i406twr 79 5 of of IN cord-286607-5i406twr 79 6 vasculitis vasculitis NN cord-286607-5i406twr 79 7 mediated mediate VBN cord-286607-5i406twr 79 8 by by IN cord-286607-5i406twr 79 9 inflammasome inflammasome NNP cord-286607-5i406twr 79 10 activation activation NN cord-286607-5i406twr 79 11 open open JJ cord-286607-5i406twr 79 12 more more RBR cord-286607-5i406twr 79 13 specifically specifically RB cord-286607-5i406twr 79 14 the the DT cord-286607-5i406twr 79 15 road road NN cord-286607-5i406twr 79 16 to to TO cord-286607-5i406twr 79 17 innate innate JJ cord-286607-5i406twr 79 18 immunity immunity NN cord-286607-5i406twr 79 19 pathways pathway NNS cord-286607-5i406twr 79 20 in in IN cord-286607-5i406twr 79 21 the the DT cord-286607-5i406twr 79 22 interpretation interpretation NN cord-286607-5i406twr 79 23 of of IN cord-286607-5i406twr 79 24 KS KS NNP cord-286607-5i406twr 79 25 ( ( -LRB- cord-286607-5i406twr 79 26 49 49 CD cord-286607-5i406twr 79 27 , , , cord-286607-5i406twr 79 28 50 50 CD cord-286607-5i406twr 79 29 ) ) -RRB- cord-286607-5i406twr 79 30 . . . cord-286607-5i406twr 80 1 Unchallengeable unchallengeable JJ cord-286607-5i406twr 80 2 proof proof NN cord-286607-5i406twr 80 3 that that IN cord-286607-5i406twr 80 4 an an DT cord-286607-5i406twr 80 5 infection infection NN cord-286607-5i406twr 80 6 is be VBZ cord-286607-5i406twr 80 7 the the DT cord-286607-5i406twr 80 8 starting starting NN cord-286607-5i406twr 80 9 point point NN cord-286607-5i406twr 80 10 of of IN cord-286607-5i406twr 80 11 KS KS NNP cord-286607-5i406twr 80 12 is be VBZ cord-286607-5i406twr 80 13 not not RB cord-286607-5i406twr 80 14 available available JJ cord-286607-5i406twr 80 15 . . . cord-286607-5i406twr 81 1 Different different JJ cord-286607-5i406twr 81 2 epidemiologic epidemiologic JJ cord-286607-5i406twr 81 3 studies study NNS cord-286607-5i406twr 81 4 have have VBP cord-286607-5i406twr 81 5 supported support VBN cord-286607-5i406twr 81 6 this this DT cord-286607-5i406twr 81 7 hypothesis hypothesis NN cord-286607-5i406twr 81 8 , , , cord-286607-5i406twr 81 9 based base VBN cord-286607-5i406twr 81 10 on on IN cord-286607-5i406twr 81 11 documented document VBN cord-286607-5i406twr 81 12 infections infection NNS cord-286607-5i406twr 81 13 by by IN cord-286607-5i406twr 81 14 various various JJ cord-286607-5i406twr 81 15 microorganisms microorganism NNS cord-286607-5i406twr 81 16 in in IN cord-286607-5i406twr 81 17 many many JJ cord-286607-5i406twr 81 18 cases case NNS cord-286607-5i406twr 81 19 of of IN cord-286607-5i406twr 81 20 KS KS NNP cord-286607-5i406twr 81 21 . . . cord-286607-5i406twr 82 1 Further further JJ cord-286607-5i406twr 82 2 clues clue NNS cord-286607-5i406twr 82 3 are be VBP cord-286607-5i406twr 82 4 the the DT cord-286607-5i406twr 82 5 occurrence occurrence NN cord-286607-5i406twr 82 6 of of IN cord-286607-5i406twr 82 7 KS KS NNP cord-286607-5i406twr 82 8 in in IN cord-286607-5i406twr 82 9 epidemics epidemic NNS cord-286607-5i406twr 82 10 , , , cord-286607-5i406twr 82 11 higher high JJR cord-286607-5i406twr 82 12 incidence incidence NN cord-286607-5i406twr 82 13 during during IN cord-286607-5i406twr 82 14 spring spring NN cord-286607-5i406twr 82 15 and and CC cord-286607-5i406twr 82 16 winter winter NN cord-286607-5i406twr 82 17 and and CC cord-286607-5i406twr 82 18 early early JJ cord-286607-5i406twr 82 19 age age NN cord-286607-5i406twr 82 20 at at IN cord-286607-5i406twr 82 21 which which WDT cord-286607-5i406twr 82 22 the the DT cord-286607-5i406twr 82 23 disease disease NN cord-286607-5i406twr 82 24 might may MD cord-286607-5i406twr 82 25 be be VB cord-286607-5i406twr 82 26 acquired acquire VBN cord-286607-5i406twr 82 27 , , , cord-286607-5i406twr 82 28 that that RB cord-286607-5i406twr 82 29 is is RB cord-286607-5i406twr 82 30 6 6 CD cord-286607-5i406twr 82 31 months month NNS cord-286607-5i406twr 82 32 to to IN cord-286607-5i406twr 82 33 5 5 CD cord-286607-5i406twr 82 34 years year NNS cord-286607-5i406twr 82 35 ( ( -LRB- cord-286607-5i406twr 82 36 5 5 CD cord-286607-5i406twr 82 37 ) ) -RRB- cord-286607-5i406twr 82 38 . . . cord-286607-5i406twr 83 1 Striking striking JJ cord-286607-5i406twr 83 2 perturbations perturbation NNS cord-286607-5i406twr 83 3 of of IN cord-286607-5i406twr 83 4 many many JJ cord-286607-5i406twr 83 5 immune immune JJ cord-286607-5i406twr 83 6 pathways pathway NNS cord-286607-5i406twr 83 7 occur occur VBP cord-286607-5i406twr 83 8 during during IN cord-286607-5i406twr 83 9 the the DT cord-286607-5i406twr 83 10 acute acute JJ cord-286607-5i406twr 83 11 phase phase NN cord-286607-5i406twr 83 12 of of IN cord-286607-5i406twr 83 13 KS KS NNP cord-286607-5i406twr 83 14 , , , cord-286607-5i406twr 83 15 which which WDT cord-286607-5i406twr 83 16 determines determine VBZ cord-286607-5i406twr 83 17 a a DT cord-286607-5i406twr 83 18 multi multi JJ cord-286607-5i406twr 83 19 - - JJ cord-286607-5i406twr 83 20 cytokine cytokine JJ cord-286607-5i406twr 83 21 cascade cascade NN cord-286607-5i406twr 83 22 in in IN cord-286607-5i406twr 83 23 the the DT cord-286607-5i406twr 83 24 vascular vascular JJ cord-286607-5i406twr 83 25 endothelium endothelium NN cord-286607-5i406twr 83 26 with with IN cord-286607-5i406twr 83 27 focal focal JJ cord-286607-5i406twr 83 28 disruption disruption NN cord-286607-5i406twr 83 29 of of IN cord-286607-5i406twr 83 30 small small JJ cord-286607-5i406twr 83 31 - - HYPH cord-286607-5i406twr 83 32 and and CC cord-286607-5i406twr 83 33 mediumsized mediumsized JJ cord-286607-5i406twr 83 34 vessels vessel NNS cord-286607-5i406twr 83 35 . . . cord-286607-5i406twr 84 1 However however RB cord-286607-5i406twr 84 2 , , , cord-286607-5i406twr 84 3 the the DT cord-286607-5i406twr 84 4 exact exact JJ cord-286607-5i406twr 84 5 key key JJ cord-286607-5i406twr 84 6 steps step NNS cord-286607-5i406twr 84 7 leading lead VBG cord-286607-5i406twr 84 8 to to IN cord-286607-5i406twr 84 9 coronary coronary JJ cord-286607-5i406twr 84 10 arteritis arteritis NN cord-286607-5i406twr 84 11 are be VBP cord-286607-5i406twr 84 12 still still RB cord-286607-5i406twr 84 13 far far RB cord-286607-5i406twr 84 14 from from IN cord-286607-5i406twr 84 15 being be VBG cord-286607-5i406twr 84 16 clarified clarify VBN cord-286607-5i406twr 84 17 , , , cord-286607-5i406twr 84 18 though though IN cord-286607-5i406twr 84 19 endothelial endothelial JJ cord-286607-5i406twr 84 20 cell cell NN cord-286607-5i406twr 84 21 activation activation NN cord-286607-5i406twr 84 22 ; ; : cord-286607-5i406twr 84 23 prolonged prolonged JJ cord-286607-5i406twr 84 24 start start NN cord-286607-5i406twr 84 25 - - HYPH cord-286607-5i406twr 84 26 up up NN cord-286607-5i406twr 84 27 of of IN cord-286607-5i406twr 84 28 neutrophils neutrophil NNS cord-286607-5i406twr 84 29 , , , cord-286607-5i406twr 84 30 CD68 CD68 NNP cord-286607-5i406twr 84 31 + + CC cord-286607-5i406twr 84 32 monocyte monocyte NNP cord-286607-5i406twr 84 33 / / SYM cord-286607-5i406twr 84 34 macrophages macrophage NNS cord-286607-5i406twr 84 35 and and CC cord-286607-5i406twr 84 36 CD8 CD8 NNP cord-286607-5i406twr 84 37 + + CC cord-286607-5i406twr 84 38 lymphocytes lymphocyte NNS cord-286607-5i406twr 84 39 ; ; : cord-286607-5i406twr 84 40 production production NN cord-286607-5i406twr 84 41 of of IN cord-286607-5i406twr 84 42 oxygen oxygen NN cord-286607-5i406twr 84 43 intermediates intermediate NNS cord-286607-5i406twr 84 44 and and CC cord-286607-5i406twr 84 45 lysosomal lysosomal JJ cord-286607-5i406twr 84 46 enzymes enzyme NNS cord-286607-5i406twr 84 47 ; ; : cord-286607-5i406twr 84 48 and and CC cord-286607-5i406twr 84 49 oligoclonal oligoclonal NNP cord-286607-5i406twr 84 50 IgA IgA NNP cord-286607-5i406twr 84 51 response response NN cord-286607-5i406twr 84 52 by by IN cord-286607-5i406twr 84 53 plasma plasma NN cord-286607-5i406twr 84 54 cells cell NNS cord-286607-5i406twr 84 55 all all DT cord-286607-5i406twr 84 56 appear appear VBP cord-286607-5i406twr 84 57 to to TO cord-286607-5i406twr 84 58 be be VB cord-286607-5i406twr 84 59 involved involve VBN cord-286607-5i406twr 84 60 ( ( -LRB- cord-286607-5i406twr 84 61 45 45 CD cord-286607-5i406twr 84 62 , , , cord-286607-5i406twr 84 63 46 46 CD cord-286607-5i406twr 84 64 , , , cord-286607-5i406twr 84 65 ( ( -LRB- cord-286607-5i406twr 84 66 51 51 CD cord-286607-5i406twr 84 67 ) ) -RRB- cord-286607-5i406twr 84 68 ( ( -LRB- cord-286607-5i406twr 84 69 52 52 CD cord-286607-5i406twr 84 70 ) ) -RRB- cord-286607-5i406twr 84 71 ( ( -LRB- cord-286607-5i406twr 84 72 53 53 CD cord-286607-5i406twr 84 73 ) ) -RRB- cord-286607-5i406twr 84 74 . . . cord-286607-5i406twr 85 1 The the DT cord-286607-5i406twr 85 2 contribution contribution NN cord-286607-5i406twr 85 3 of of IN cord-286607-5i406twr 85 4 viruses virus NNS cord-286607-5i406twr 85 5 to to IN cord-286607-5i406twr 85 6 KS KS NNP cord-286607-5i406twr 85 7 has have VBZ cord-286607-5i406twr 85 8 been be VBN cord-286607-5i406twr 85 9 suggested suggest VBN cord-286607-5i406twr 85 10 by by IN cord-286607-5i406twr 85 11 ultrastructural ultrastructural JJ cord-286607-5i406twr 85 12 studies study NNS cord-286607-5i406twr 85 13 which which WDT cord-286607-5i406twr 85 14 found find VBD cord-286607-5i406twr 85 15 cytoplasmic cytoplasmic JJ cord-286607-5i406twr 85 16 inclusion inclusion NN cord-286607-5i406twr 85 17 bodies body NNS cord-286607-5i406twr 85 18 containing contain VBG cord-286607-5i406twr 85 19 RNA RNA NNP cord-286607-5i406twr 85 20 of of IN cord-286607-5i406twr 85 21 viral viral JJ cord-286607-5i406twr 85 22 origin origin NN cord-286607-5i406twr 85 23 in in IN cord-286607-5i406twr 85 24 the the DT cord-286607-5i406twr 85 25 bronchial bronchial JJ cord-286607-5i406twr 85 26 epithelia epithelium NNS cord-286607-5i406twr 85 27 ( ( -LRB- cord-286607-5i406twr 85 28 54 54 CD cord-286607-5i406twr 85 29 ) ) -RRB- cord-286607-5i406twr 85 30 as as RB cord-286607-5i406twr 85 31 well well RB cord-286607-5i406twr 85 32 as as IN cord-286607-5i406twr 85 33 by by IN cord-286607-5i406twr 85 34 studies study NNS cord-286607-5i406twr 85 35 revealing reveal VBG cord-286607-5i406twr 85 36 the the DT cord-286607-5i406twr 85 37 detection detection NN cord-286607-5i406twr 85 38 of of IN cord-286607-5i406twr 85 39 intracytoplasmic intracytoplasmic JJ cord-286607-5i406twr 85 40 inclusion inclusion NN cord-286607-5i406twr 85 41 bodies body NNS cord-286607-5i406twr 85 42 containing contain VBG cord-286607-5i406twr 85 43 viral viral JJ cord-286607-5i406twr 85 44 proteins protein NNS cord-286607-5i406twr 85 45 and and CC cord-286607-5i406twr 85 46 nucleic nucleic JJ cord-286607-5i406twr 85 47 acid acid NN cord-286607-5i406twr 85 48 aggregates aggregate NNS cord-286607-5i406twr 85 49 ( ( -LRB- cord-286607-5i406twr 85 50 55 55 CD cord-286607-5i406twr 85 51 , , , cord-286607-5i406twr 85 52 56 56 CD cord-286607-5i406twr 85 53 ) ) -RRB- cord-286607-5i406twr 85 54 . . . cord-286607-5i406twr 86 1 Recent recent JJ cord-286607-5i406twr 86 2 investigations investigation NNS cord-286607-5i406twr 86 3 have have VBP cord-286607-5i406twr 86 4 supported support VBN cord-286607-5i406twr 86 5 the the DT cord-286607-5i406twr 86 6 hypothesis hypothesis NN cord-286607-5i406twr 86 7 that that IN cord-286607-5i406twr 86 8 immune immune JJ cord-286607-5i406twr 86 9 responses response NNS cord-286607-5i406twr 86 10 in in IN cord-286607-5i406twr 86 11 KS KS NNP cord-286607-5i406twr 86 12 are be VBP cord-286607-5i406twr 86 13 oligoclonal oligoclonal JJ cord-286607-5i406twr 86 14 rather rather RB cord-286607-5i406twr 86 15 than than IN cord-286607-5i406twr 86 16 polyclonal polyclonal JJ cord-286607-5i406twr 86 17 ( ( -LRB- cord-286607-5i406twr 86 18 as as IN cord-286607-5i406twr 86 19 found find VBN cord-286607-5i406twr 86 20 typically typically RB cord-286607-5i406twr 86 21 in in IN cord-286607-5i406twr 86 22 superantigen superantigen NN cord-286607-5i406twr 86 23 - - HYPH cord-286607-5i406twr 86 24 driven drive VBN cord-286607-5i406twr 86 25 responses response NNS cord-286607-5i406twr 86 26 ) ) -RRB- cord-286607-5i406twr 86 27 , , , cord-286607-5i406twr 86 28 and and CC cord-286607-5i406twr 86 29 that that IN cord-286607-5i406twr 86 30 IgA IgA NNP cord-286607-5i406twr 86 31 plasma plasma NN cord-286607-5i406twr 86 32 cells cell NNS cord-286607-5i406twr 86 33 play play VBP cord-286607-5i406twr 86 34 a a DT cord-286607-5i406twr 86 35 crucial crucial JJ cord-286607-5i406twr 86 36 role role NN cord-286607-5i406twr 86 37 . . . cord-286607-5i406twr 87 1 Indeed indeed RB cord-286607-5i406twr 87 2 , , , cord-286607-5i406twr 87 3 higher high JJR cord-286607-5i406twr 87 4 levels level NNS cord-286607-5i406twr 87 5 of of IN cord-286607-5i406twr 87 6 IgA IgA NNP cord-286607-5i406twr 87 7 have have VBP cord-286607-5i406twr 87 8 been be VBN cord-286607-5i406twr 87 9 found find VBN cord-286607-5i406twr 87 10 in in IN cord-286607-5i406twr 87 11 the the DT cord-286607-5i406twr 87 12 vasculature vasculature NN cord-286607-5i406twr 87 13 of of IN cord-286607-5i406twr 87 14 patients patient NNS cord-286607-5i406twr 87 15 with with IN cord-286607-5i406twr 87 16 previous previous JJ cord-286607-5i406twr 87 17 KS KS NNP cord-286607-5i406twr 87 18 , , , cord-286607-5i406twr 87 19 indicating indicate VBG cord-286607-5i406twr 87 20 an an DT cord-286607-5i406twr 87 21 antigen antigen NN cord-286607-5i406twr 87 22 - - HYPH cord-286607-5i406twr 87 23 driven drive VBN cord-286607-5i406twr 87 24 response response NN cord-286607-5i406twr 87 25 against against IN cord-286607-5i406twr 87 26 an an DT cord-286607-5i406twr 87 27 etiologic etiologic JJ cord-286607-5i406twr 87 28 agent agent NN cord-286607-5i406twr 87 29 which which WDT cord-286607-5i406twr 87 30 might may MD cord-286607-5i406twr 87 31 have have VB cord-286607-5i406twr 87 32 a a DT cord-286607-5i406twr 87 33 respiratory respiratory JJ cord-286607-5i406twr 87 34 or or CC cord-286607-5i406twr 87 35 gastrointestinal gastrointestinal JJ cord-286607-5i406twr 87 36 portal portal NN cord-286607-5i406twr 87 37 of of IN cord-286607-5i406twr 87 38 entry entry NN cord-286607-5i406twr 87 39 ( ( -LRB- cord-286607-5i406twr 87 40 57 57 CD cord-286607-5i406twr 87 41 ) ) -RRB- cord-286607-5i406twr 87 42 . . . cord-286607-5i406twr 88 1 About about RB cord-286607-5i406twr 88 2 half half NN cord-286607-5i406twr 88 3 of of IN cord-286607-5i406twr 88 4 all all DT cord-286607-5i406twr 88 5 KS KS NNP cord-286607-5i406twr 88 6 patients patient NNS cord-286607-5i406twr 88 7 might may MD cord-286607-5i406twr 88 8 have have VB cord-286607-5i406twr 88 9 one one CD cord-286607-5i406twr 88 10 or or CC cord-286607-5i406twr 88 11 more more JJR cord-286607-5i406twr 88 12 respiratory respiratory JJ cord-286607-5i406twr 88 13 viruses virus NNS cord-286607-5i406twr 88 14 detected detect VBN cord-286607-5i406twr 88 15 by by IN cord-286607-5i406twr 88 16 polymerase polymerase NN cord-286607-5i406twr 88 17 chain chain NN cord-286607-5i406twr 88 18 reaction reaction NN cord-286607-5i406twr 88 19 , , , cord-286607-5i406twr 88 20 without without IN cord-286607-5i406twr 88 21 any any DT cord-286607-5i406twr 88 22 particular particular JJ cord-286607-5i406twr 88 23 predominance predominance NN cord-286607-5i406twr 88 24 , , , cord-286607-5i406twr 88 25 but but CC cord-286607-5i406twr 88 26 a a DT cord-286607-5i406twr 88 27 positive positive JJ cord-286607-5i406twr 88 28 respiratory respiratory JJ cord-286607-5i406twr 88 29 viral viral JJ cord-286607-5i406twr 88 30 test test NN cord-286607-5i406twr 88 31 or or CC cord-286607-5i406twr 88 32 presence presence NN cord-286607-5i406twr 88 33 of of IN cord-286607-5i406twr 88 34 respiratory respiratory JJ cord-286607-5i406twr 88 35 symptoms symptom NNS cord-286607-5i406twr 88 36 at at IN cord-286607-5i406twr 88 37 the the DT cord-286607-5i406twr 88 38 time time NN cord-286607-5i406twr 88 39 of of IN cord-286607-5i406twr 88 40 presentation presentation NN cord-286607-5i406twr 88 41 should should MD cord-286607-5i406twr 88 42 not not RB cord-286607-5i406twr 88 43 be be VB cord-286607-5i406twr 88 44 used use VBN cord-286607-5i406twr 88 45 to to TO cord-286607-5i406twr 88 46 exclude exclude VB cord-286607-5i406twr 88 47 the the DT cord-286607-5i406twr 88 48 diagnosis diagnosis NN cord-286607-5i406twr 88 49 of of IN cord-286607-5i406twr 88 50 KS KS NNP cord-286607-5i406twr 88 51 ( ( -LRB- cord-286607-5i406twr 88 52 58 58 CD cord-286607-5i406twr 88 53 ) ) -RRB- cord-286607-5i406twr 88 54 . . . cord-286607-5i406twr 89 1 Other other JJ cord-286607-5i406twr 89 2 studies study NNS cord-286607-5i406twr 89 3 have have VBP cord-286607-5i406twr 89 4 investigated investigate VBN cord-286607-5i406twr 89 5 a a DT cord-286607-5i406twr 89 6 potential potential JJ cord-286607-5i406twr 89 7 relationship relationship NN cord-286607-5i406twr 89 8 of of IN cord-286607-5i406twr 89 9 KS KS NNP cord-286607-5i406twr 89 10 with with IN cord-286607-5i406twr 89 11 coronaviruses coronaviruse NNS cord-286607-5i406twr 89 12 , , , cord-286607-5i406twr 89 13 though though IN cord-286607-5i406twr 89 14 without without IN cord-286607-5i406twr 89 15 finding find VBG cord-286607-5i406twr 89 16 definite definite JJ cord-286607-5i406twr 89 17 proof proof NN cord-286607-5i406twr 89 18 of of IN cord-286607-5i406twr 89 19 cause cause NN cord-286607-5i406twr 89 20 and and CC cord-286607-5i406twr 89 21 effect effect NN cord-286607-5i406twr 89 22 ( ( -LRB- cord-286607-5i406twr 89 23 59 59 CD cord-286607-5i406twr 89 24 , , , cord-286607-5i406twr 89 25 60 60 CD cord-286607-5i406twr 89 26 ) ) -RRB- cord-286607-5i406twr 89 27 . . . cord-286607-5i406twr 90 1 Many many JJ cord-286607-5i406twr 90 2 viruses virus NNS cord-286607-5i406twr 90 3 have have VBP cord-286607-5i406twr 90 4 been be VBN cord-286607-5i406twr 90 5 suggested suggest VBN cord-286607-5i406twr 90 6 to to TO cord-286607-5i406twr 90 7 be be VB cord-286607-5i406twr 90 8 implicated implicate VBN cord-286607-5i406twr 90 9 in in IN cord-286607-5i406twr 90 10 the the DT cord-286607-5i406twr 90 11 pathogenesis pathogenesis NN cord-286607-5i406twr 90 12 of of IN cord-286607-5i406twr 90 13 KS KS NNP cord-286607-5i406twr 90 14 , , , cord-286607-5i406twr 90 15 such such JJ cord-286607-5i406twr 90 16 as as IN cord-286607-5i406twr 90 17 adenovirus adenovirus NN cord-286607-5i406twr 90 18 , , , cord-286607-5i406twr 90 19 parvovirus parvovirus NN cord-286607-5i406twr 90 20 B19 B19 NNP cord-286607-5i406twr 90 21 , , , cord-286607-5i406twr 90 22 rotavirus rotavirus NN cord-286607-5i406twr 90 23 , , . cord-286607-5i406twr 91 1 H1N1 H1N1 NNP cord-286607-5i406twr 91 2 influenza influenza NN cord-286607-5i406twr 91 3 virus virus NN cord-286607-5i406twr 91 4 , , , cord-286607-5i406twr 91 5 Epstein Epstein NNP cord-286607-5i406twr 91 6 - - HYPH cord-286607-5i406twr 91 7 Barr Barr NNP cord-286607-5i406twr 91 8 virus virus NN cord-286607-5i406twr 91 9 , , , cord-286607-5i406twr 91 10 herpesvirus herpesvirus NNP cord-286607-5i406twr 91 11 6 6 CD cord-286607-5i406twr 91 12 , , , cord-286607-5i406twr 91 13 coxsackie coxsackie NNP cord-286607-5i406twr 91 14 B3 B3 NNP cord-286607-5i406twr 91 15 virus virus NN cord-286607-5i406twr 91 16 , , , cord-286607-5i406twr 91 17 parainfluenza parainfluenza NNP cord-286607-5i406twr 91 18 virus virus NNP cord-286607-5i406twr 91 19 type type NNP cord-286607-5i406twr 91 20 3 3 CD cord-286607-5i406twr 91 21 , , , cord-286607-5i406twr 91 22 measles measles NN cord-286607-5i406twr 91 23 virus virus NN cord-286607-5i406twr 91 24 , , , cord-286607-5i406twr 91 25 dengue dengue NN cord-286607-5i406twr 91 26 virus virus NN cord-286607-5i406twr 91 27 , , , cord-286607-5i406twr 91 28 human human JJ cord-286607-5i406twr 91 29 immunodeficiency immunodeficiency NN cord-286607-5i406twr 91 30 virus virus NN cord-286607-5i406twr 91 31 , , , cord-286607-5i406twr 91 32 and and CC cord-286607-5i406twr 91 33 varicella varicella NN cord-286607-5i406twr 91 34 - - HYPH cord-286607-5i406twr 91 35 zoster zoster NN cord-286607-5i406twr 91 36 virus virus NN cord-286607-5i406twr 91 37 , , , cord-286607-5i406twr 91 38 but but CC cord-286607-5i406twr 91 39 no no DT cord-286607-5i406twr 91 40 significant significant JJ cord-286607-5i406twr 91 41 differences difference NNS cord-286607-5i406twr 91 42 emerged emerge VBD cord-286607-5i406twr 91 43 from from IN cord-286607-5i406twr 91 44 case case NN cord-286607-5i406twr 91 45 - - HYPH cord-286607-5i406twr 91 46 controlled control VBN cord-286607-5i406twr 91 47 studies study NNS cord-286607-5i406twr 91 48 ( ( -LRB- cord-286607-5i406twr 91 49 61 61 CD cord-286607-5i406twr 91 50 ) ) -RRB- cord-286607-5i406twr 91 51 ( ( -LRB- cord-286607-5i406twr 91 52 62 62 CD cord-286607-5i406twr 91 53 ) ) -RRB- cord-286607-5i406twr 91 54 ( ( -LRB- cord-286607-5i406twr 91 55 63 63 CD cord-286607-5i406twr 91 56 ) ) -RRB- cord-286607-5i406twr 91 57 ( ( -LRB- cord-286607-5i406twr 91 58 64 64 CD cord-286607-5i406twr 91 59 ) ) -RRB- cord-286607-5i406twr 91 60 ( ( -LRB- cord-286607-5i406twr 91 61 65 65 CD cord-286607-5i406twr 91 62 ) ) -RRB- cord-286607-5i406twr 91 63 ( ( -LRB- cord-286607-5i406twr 91 64 66 66 CD cord-286607-5i406twr 91 65 ) ) -RRB- cord-286607-5i406twr 91 66 ( ( -LRB- cord-286607-5i406twr 91 67 67 67 CD cord-286607-5i406twr 91 68 ) ) -RRB- cord-286607-5i406twr 91 69 ( ( -LRB- cord-286607-5i406twr 91 70 68 68 CD cord-286607-5i406twr 91 71 ) ) -RRB- cord-286607-5i406twr 91 72 ( ( -LRB- cord-286607-5i406twr 91 73 69 69 CD cord-286607-5i406twr 91 74 ) ) -RRB- cord-286607-5i406twr 91 75 . . . cord-286607-5i406twr 92 1 One one CD cord-286607-5i406twr 92 2 of of IN cord-286607-5i406twr 92 3 the the DT cord-286607-5i406twr 92 4 most most RBS cord-286607-5i406twr 92 5 difficult difficult JJ cord-286607-5i406twr 92 6 infections infection NNS cord-286607-5i406twr 92 7 that that WDT cord-286607-5i406twr 92 8 are be VBP cord-286607-5i406twr 92 9 harder hard JJR cord-286607-5i406twr 92 10 to to TO cord-286607-5i406twr 92 11 distinguish distinguish VB cord-286607-5i406twr 92 12 from from IN cord-286607-5i406twr 92 13 KS KS NNP cord-286607-5i406twr 92 14 is be VBZ cord-286607-5i406twr 92 15 caused cause VBN cord-286607-5i406twr 92 16 by by IN cord-286607-5i406twr 92 17 adenovirus adenovirus NN cord-286607-5i406twr 92 18 , , , cord-286607-5i406twr 92 19 due due IN cord-286607-5i406twr 92 20 to to IN cord-286607-5i406twr 92 21 its -PRON- PRP$ cord-286607-5i406twr 92 22 frequent frequent JJ cord-286607-5i406twr 92 23 incidental incidental JJ cord-286607-5i406twr 92 24 detection detection NN cord-286607-5i406twr 92 25 in in IN cord-286607-5i406twr 92 26 KS KS NNP cord-286607-5i406twr 92 27 patients patient NNS cord-286607-5i406twr 92 28 and and CC cord-286607-5i406twr 92 29 frequent frequent JJ cord-286607-5i406twr 92 30 laboratory laboratory NN cord-286607-5i406twr 92 31 finding finding NN cord-286607-5i406twr 92 32 of of IN cord-286607-5i406twr 92 33 increased increase VBN cord-286607-5i406twr 92 34 inflammatory inflammatory JJ cord-286607-5i406twr 92 35 markers marker NNS cord-286607-5i406twr 92 36 ( ( -LRB- cord-286607-5i406twr 92 37 70 70 CD cord-286607-5i406twr 92 38 ) ) -RRB- cord-286607-5i406twr 92 39 . . . cord-286607-5i406twr 93 1 In in IN cord-286607-5i406twr 93 2 particular particular JJ cord-286607-5i406twr 93 3 , , , cord-286607-5i406twr 93 4 adenovirus adenovirus NN cord-286607-5i406twr 93 5 has have VBZ cord-286607-5i406twr 93 6 been be VBN cord-286607-5i406twr 93 7 detected detect VBN cord-286607-5i406twr 93 8 in in IN cord-286607-5i406twr 93 9 8.8 8.8 CD cord-286607-5i406twr 93 10 and and CC cord-286607-5i406twr 93 11 25 25 CD cord-286607-5i406twr 93 12 % % NN cord-286607-5i406twr 93 13 of of IN cord-286607-5i406twr 93 14 cases case NNS cord-286607-5i406twr 93 15 with with IN cord-286607-5i406twr 93 16 complete complete JJ cord-286607-5i406twr 93 17 and and CC cord-286607-5i406twr 93 18 incomplete incomplete JJ cord-286607-5i406twr 93 19 KS KS NNP cord-286607-5i406twr 93 20 , , , cord-286607-5i406twr 93 21 respectively respectively RB cord-286607-5i406twr 93 22 , , , cord-286607-5i406twr 93 23 by by IN cord-286607-5i406twr 93 24 Jaggi Jaggi NNP cord-286607-5i406twr 93 25 et et NNP cord-286607-5i406twr 93 26 al al NNP cord-286607-5i406twr 93 27 . . . cord-286607-5i406twr 94 1 ( ( -LRB- cord-286607-5i406twr 94 2 71 71 CD cord-286607-5i406twr 94 3 ) ) -RRB- cord-286607-5i406twr 94 4 . . . cord-286607-5i406twr 95 1 There there EX cord-286607-5i406twr 95 2 are be VBP cord-286607-5i406twr 95 3 reports report NNS cord-286607-5i406twr 95 4 that that WDT cord-286607-5i406twr 95 5 have have VBP cord-286607-5i406twr 95 6 emphasized emphasize VBN cord-286607-5i406twr 95 7 the the DT cord-286607-5i406twr 95 8 possible possible JJ cord-286607-5i406twr 95 9 relationship relationship NN cord-286607-5i406twr 95 10 of of IN cord-286607-5i406twr 95 11 cytomegalovirus cytomegalovirus NNP cord-286607-5i406twr 95 12 ( ( -LRB- cord-286607-5i406twr 95 13 in in IN cord-286607-5i406twr 95 14 one one CD cord-286607-5i406twr 95 15 child child NN cord-286607-5i406twr 95 16 from from IN cord-286607-5i406twr 95 17 Turkey Turkey NNP cord-286607-5i406twr 95 18 ) ) -RRB- cord-286607-5i406twr 95 19 and and CC cord-286607-5i406twr 95 20 human human JJ cord-286607-5i406twr 95 21 bocavirus bocavirus NNP cord-286607-5i406twr 95 22 1 1 CD cord-286607-5i406twr 95 23 ( ( -LRB- cord-286607-5i406twr 95 24 in in IN cord-286607-5i406twr 95 25 a a DT cord-286607-5i406twr 95 26 French french JJ cord-286607-5i406twr 95 27 cohort cohort NN cord-286607-5i406twr 95 28 of of IN cord-286607-5i406twr 95 29 32 32 CD cord-286607-5i406twr 95 30 patients patient NNS cord-286607-5i406twr 95 31 ) ) -RRB- cord-286607-5i406twr 95 32 with with IN cord-286607-5i406twr 95 33 KS KS NNP cord-286607-5i406twr 95 34 through through IN cord-286607-5i406twr 95 35 serologic serologic JJ cord-286607-5i406twr 95 36 tests test NNS cord-286607-5i406twr 95 37 and and CC cord-286607-5i406twr 95 38 molecular molecular JJ cord-286607-5i406twr 95 39 techniques technique NNS cord-286607-5i406twr 95 40 , , , cord-286607-5i406twr 95 41 but but CC cord-286607-5i406twr 95 42 this this DT cord-286607-5i406twr 95 43 link link NN cord-286607-5i406twr 95 44 might may MD cord-286607-5i406twr 95 45 be be VB cord-286607-5i406twr 95 46 only only RB cord-286607-5i406twr 95 47 casual casual JJ cord-286607-5i406twr 95 48 and and CC cord-286607-5i406twr 95 49 misleading misleading JJ cord-286607-5i406twr 95 50 ( ( -LRB- cord-286607-5i406twr 95 51 72 72 CD cord-286607-5i406twr 95 52 , , , cord-286607-5i406twr 95 53 73 73 CD cord-286607-5i406twr 95 54 ) ) -RRB- cord-286607-5i406twr 95 55 . . . cord-286607-5i406twr 96 1 Regarding regard VBG cord-286607-5i406twr 96 2 the the DT cord-286607-5i406twr 96 3 bacterial bacterial JJ cord-286607-5i406twr 96 4 origin origin NN cord-286607-5i406twr 96 5 of of IN cord-286607-5i406twr 96 6 KS KS NNP cord-286607-5i406twr 96 7 , , , cord-286607-5i406twr 96 8 it -PRON- PRP cord-286607-5i406twr 96 9 is be VBZ cord-286607-5i406twr 96 10 debated debate VBN cord-286607-5i406twr 96 11 if if IN cord-286607-5i406twr 96 12 the the DT cord-286607-5i406twr 96 13 infectious infectious JJ cord-286607-5i406twr 96 14 agents agent NNS cord-286607-5i406twr 96 15 might may MD cord-286607-5i406twr 96 16 be be VB cord-286607-5i406twr 96 17 conventional conventional JJ cord-286607-5i406twr 96 18 bacteria bacteria NNS cord-286607-5i406twr 96 19 or or CC cord-286607-5i406twr 96 20 bacteria bacteria NNS cord-286607-5i406twr 96 21 with with IN cord-286607-5i406twr 96 22 superantigen superantigen NN cord-286607-5i406twr 96 23 activity activity NN cord-286607-5i406twr 96 24 . . . cord-286607-5i406twr 97 1 Superantigens Superantigens NNP cord-286607-5i406twr 97 2 ( ( -LRB- cord-286607-5i406twr 97 3 SAgs SAgs NNP cord-286607-5i406twr 97 4 ) ) -RRB- cord-286607-5i406twr 97 5 are be VBP cord-286607-5i406twr 97 6 the the DT cord-286607-5i406twr 97 7 most most RBS cord-286607-5i406twr 97 8 powerful powerful JJ cord-286607-5i406twr 97 9 T t NN cord-286607-5i406twr 97 10 cell cell NN cord-286607-5i406twr 97 11 mitogens mitogen VBN cord-286607-5i406twr 97 12 ever ever RB cord-286607-5i406twr 97 13 discovered discover VBN cord-286607-5i406twr 97 14 , , , cord-286607-5i406twr 97 15 with with IN cord-286607-5i406twr 97 16 potent potent JJ cord-286607-5i406twr 97 17 immunostimulatory immunostimulatory JJ cord-286607-5i406twr 97 18 actions action NNS cord-286607-5i406twr 97 19 that that WDT cord-286607-5i406twr 97 20 simultaneously simultaneously RB cord-286607-5i406twr 97 21 activate activate VBP cord-286607-5i406twr 97 22 the the DT cord-286607-5i406twr 97 23 major major JJ cord-286607-5i406twr 97 24 histocompatibility histocompatibility NN cord-286607-5i406twr 97 25 complex complex JJ cord-286607-5i406twr 97 26 class class NN cord-286607-5i406twr 97 27 II ii CD cord-286607-5i406twr 97 28 molecules molecule NNS cord-286607-5i406twr 97 29 and and CC cord-286607-5i406twr 97 30 T T NNP cord-286607-5i406twr 97 31 cell cell NN cord-286607-5i406twr 97 32 receptors receptor NNS cord-286607-5i406twr 97 33 , , , cord-286607-5i406twr 97 34 leading lead VBG cord-286607-5i406twr 97 35 to to IN cord-286607-5i406twr 97 36 massive massive JJ cord-286607-5i406twr 97 37 activation activation NN cord-286607-5i406twr 97 38 of of IN cord-286607-5i406twr 97 39 various various JJ cord-286607-5i406twr 97 40 immune immune JJ cord-286607-5i406twr 97 41 cells cell NNS cord-286607-5i406twr 97 42 . . . cord-286607-5i406twr 98 1 Matsubara Matsubara NNP cord-286607-5i406twr 98 2 et et NNP cord-286607-5i406twr 98 3 al al NNP cord-286607-5i406twr 98 4 . . NNP cord-286607-5i406twr 98 5 conducted conduct VBD cord-286607-5i406twr 98 6 a a DT cord-286607-5i406twr 98 7 case case NN cord-286607-5i406twr 98 8 - - HYPH cord-286607-5i406twr 98 9 control control NN cord-286607-5i406twr 98 10 study study NN cord-286607-5i406twr 98 11 with with IN cord-286607-5i406twr 98 12 a a DT cord-286607-5i406twr 98 13 serological serological JJ cord-286607-5i406twr 98 14 approach approach NN cord-286607-5i406twr 98 15 based base VBN cord-286607-5i406twr 98 16 on on IN cord-286607-5i406twr 98 17 enzyme enzyme NN cord-286607-5i406twr 98 18 - - HYPH cord-286607-5i406twr 98 19 linked link VBN cord-286607-5i406twr 98 20 immunosorbent immunosorbent JJ cord-286607-5i406twr 98 21 assay assay NN cord-286607-5i406twr 98 22 and and CC cord-286607-5i406twr 98 23 measured measure VBN cord-286607-5i406twr 98 24 serum serum NN cord-286607-5i406twr 98 25 antibodies antibody NNS cord-286607-5i406twr 98 26 against against IN cord-286607-5i406twr 98 27 staphylococcal staphylococcal JJ cord-286607-5i406twr 98 28 enterotoxins enterotoxin NNS cord-286607-5i406twr 98 29 , , , cord-286607-5i406twr 98 30 including include VBG cord-286607-5i406twr 98 31 TSST-1 TSST-1 NNP cord-286607-5i406twr 98 32 , , , cord-286607-5i406twr 98 33 and and CC cord-286607-5i406twr 98 34 streptococcal streptococcal JJ cord-286607-5i406twr 98 35 pyrogenic pyrogenic JJ cord-286607-5i406twr 98 36 exotoxin exotoxin NN cord-286607-5i406twr 98 37 ( ( -LRB- cord-286607-5i406twr 98 38 SPE SPE NNP cord-286607-5i406twr 98 39 ) ) -RRB- cord-286607-5i406twr 98 40 , , , cord-286607-5i406twr 98 41 such such JJ cord-286607-5i406twr 98 42 as as IN cord-286607-5i406twr 99 1 SPE SPE NNP cord-286607-5i406twr 99 2 - - HYPH cord-286607-5i406twr 99 3 A. A. NNP cord-286607-5i406twr 99 4 They -PRON- PRP cord-286607-5i406twr 99 5 showed show VBD cord-286607-5i406twr 99 6 that that IN cord-286607-5i406twr 99 7 KS KS NNP cord-286607-5i406twr 99 8 patients patient NNS cord-286607-5i406twr 99 9 had have VBD cord-286607-5i406twr 99 10 significant significant JJ cord-286607-5i406twr 99 11 elevation elevation NN cord-286607-5i406twr 99 12 of of IN cord-286607-5i406twr 99 13 IgM IgM NNP cord-286607-5i406twr 99 14 antibodies antibody NNS cord-286607-5i406twr 99 15 against against IN cord-286607-5i406twr 99 16 one one CD cord-286607-5i406twr 99 17 or or CC cord-286607-5i406twr 99 18 more more JJR cord-286607-5i406twr 99 19 of of IN cord-286607-5i406twr 99 20 five five CD cord-286607-5i406twr 99 21 SAgs SAgs NNP cord-286607-5i406twr 99 22 throughout throughout IN cord-286607-5i406twr 99 23 the the DT cord-286607-5i406twr 99 24 first first JJ cord-286607-5i406twr 99 25 to to IN cord-286607-5i406twr 99 26 the the DT cord-286607-5i406twr 99 27 fourth fourth JJ cord-286607-5i406twr 99 28 disease disease NN cord-286607-5i406twr 99 29 week week NN cord-286607-5i406twr 99 30 ( ( -LRB- cord-286607-5i406twr 99 31 76 76 CD cord-286607-5i406twr 99 32 ) ) -RRB- cord-286607-5i406twr 99 33 . . . cord-286607-5i406twr 100 1 In in IN cord-286607-5i406twr 100 2 a a DT cord-286607-5i406twr 100 3 further further JJ cord-286607-5i406twr 100 4 paper paper NN cord-286607-5i406twr 100 5 the the DT cord-286607-5i406twr 100 6 same same JJ cord-286607-5i406twr 100 7 authors author NNS cord-286607-5i406twr 100 8 analyzed analyze VBD cord-286607-5i406twr 100 9 the the DT cord-286607-5i406twr 100 10 studies study NNS cord-286607-5i406twr 100 11 regarding regard VBG cord-286607-5i406twr 100 12 the the DT cord-286607-5i406twr 100 13 role role NN cord-286607-5i406twr 100 14 of of IN cord-286607-5i406twr 100 15 SAgs SAgs NNP cord-286607-5i406twr 100 16 produced produce VBN cord-286607-5i406twr 100 17 by by IN cord-286607-5i406twr 100 18 Staphylococcus Staphylococcus NNP cord-286607-5i406twr 100 19 aureus aureus NN cord-286607-5i406twr 100 20 and and CC cord-286607-5i406twr 100 21 Streptococcus streptococcus NN cord-286607-5i406twr 100 22 pyogenes pyogene NNS cord-286607-5i406twr 100 23 in in IN cord-286607-5i406twr 100 24 the the DT cord-286607-5i406twr 100 25 pathogenesis pathogenesis NN cord-286607-5i406twr 100 26 of of IN cord-286607-5i406twr 100 27 KS KS NNP cord-286607-5i406twr 100 28 , , , cord-286607-5i406twr 100 29 finding find VBG cord-286607-5i406twr 100 30 numerous numerous JJ cord-286607-5i406twr 100 31 SAgs SAgs NNP cord-286607-5i406twr 100 32 implicated implicate VBN cord-286607-5i406twr 100 33 , , , cord-286607-5i406twr 100 34 which which WDT cord-286607-5i406twr 100 35 brought bring VBD cord-286607-5i406twr 100 36 the the DT cord-286607-5i406twr 100 37 total total JJ cord-286607-5i406twr 100 38 number number NN cord-286607-5i406twr 100 39 of of IN cord-286607-5i406twr 100 40 the the DT cord-286607-5i406twr 100 41 known know VBN cord-286607-5i406twr 100 42 staphylococcal staphylococcal JJ cord-286607-5i406twr 100 43 SAgs SAgs NNP cord-286607-5i406twr 100 44 to to IN cord-286607-5i406twr 100 45 over over IN cord-286607-5i406twr 100 46 20 20 CD cord-286607-5i406twr 100 47 and and CC cord-286607-5i406twr 100 48 streptococcal streptococcal JJ cord-286607-5i406twr 100 49 SAgs SAgs NNP cord-286607-5i406twr 100 50 to to IN cord-286607-5i406twr 100 51 12 12 CD cord-286607-5i406twr 100 52 ( ( -LRB- cord-286607-5i406twr 100 53 77 77 CD cord-286607-5i406twr 100 54 ) ) -RRB- cord-286607-5i406twr 100 55 . . . cord-286607-5i406twr 101 1 The the DT cord-286607-5i406twr 101 2 most most RBS cord-286607-5i406twr 101 3 recent recent JJ cord-286607-5i406twr 101 4 work work NN cord-286607-5i406twr 101 5 that that WDT cord-286607-5i406twr 101 6 analyzed analyze VBD cord-286607-5i406twr 101 7 the the DT cord-286607-5i406twr 101 8 relationship relationship NN cord-286607-5i406twr 101 9 between between IN cord-286607-5i406twr 101 10 SAgs SAgs NNP cord-286607-5i406twr 101 11 and and CC cord-286607-5i406twr 101 12 KS KS NNP cord-286607-5i406twr 101 13 examined examine VBD cord-286607-5i406twr 101 14 different different JJ cord-286607-5i406twr 101 15 SAg SAg NNS cord-286607-5i406twr 101 16 derived derive VBN cord-286607-5i406twr 101 17 from from IN cord-286607-5i406twr 101 18 Streptococcus streptococcus NN cord-286607-5i406twr 101 19 pyogenes pyogene NNS cord-286607-5i406twr 101 20 in in IN cord-286607-5i406twr 101 21 the the DT cord-286607-5i406twr 101 22 stools stool NNS cord-286607-5i406twr 101 23 of of IN cord-286607-5i406twr 101 24 patients patient NNS cord-286607-5i406twr 101 25 with with IN cord-286607-5i406twr 101 26 KS KS NNP cord-286607-5i406twr 101 27 . . . cord-286607-5i406twr 102 1 Stool stool NN cord-286607-5i406twr 102 2 specimens specimen NNS cord-286607-5i406twr 102 3 were be VBD cord-286607-5i406twr 102 4 obtained obtain VBN cord-286607-5i406twr 102 5 from from IN cord-286607-5i406twr 102 6 36 36 CD cord-286607-5i406twr 102 7 patients patient NNS cord-286607-5i406twr 102 8 with with IN cord-286607-5i406twr 102 9 KS KS NNP cord-286607-5i406twr 102 10 during during IN cord-286607-5i406twr 102 11 the the DT cord-286607-5i406twr 102 12 acute acute JJ cord-286607-5i406twr 102 13 phase phase NN cord-286607-5i406twr 102 14 and and CC cord-286607-5i406twr 102 15 26 26 CD cord-286607-5i406twr 102 16 age age NN cord-286607-5i406twr 102 17 - - HYPH cord-286607-5i406twr 102 18 matched match VBN cord-286607-5i406twr 102 19 healthy healthy JJ cord-286607-5i406twr 102 20 children child NNS cord-286607-5i406twr 102 21 . . . cord-286607-5i406twr 103 1 The the DT cord-286607-5i406twr 103 2 authors author NNS cord-286607-5i406twr 103 3 examined examine VBD cord-286607-5i406twr 103 4 genes gene NNS cord-286607-5i406twr 103 5 related relate VBN cord-286607-5i406twr 103 6 to to IN cord-286607-5i406twr 103 7 five five CD cord-286607-5i406twr 103 8 Sags sag NNS cord-286607-5i406twr 103 9 - - HYPH cord-286607-5i406twr 103 10 SPE spe NN cord-286607-5i406twr 103 11 - - HYPH cord-286607-5i406twr 103 12 A A NNP cord-286607-5i406twr 103 13 , , , cord-286607-5i406twr 103 14 SPE SPE NNP cord-286607-5i406twr 103 15 - - HYPH cord-286607-5i406twr 103 16 C C NNP cord-286607-5i406twr 103 17 , , , cord-286607-5i406twr 103 18 SPE SPE NNP cord-286607-5i406twr 103 19 - - HYPH cord-286607-5i406twr 103 20 G G NNP cord-286607-5i406twr 103 21 , , , cord-286607-5i406twr 103 22 SPE SPE NNP cord-286607-5i406twr 103 23 - - HYPH cord-286607-5i406twr 103 24 J J NNP cord-286607-5i406twr 103 25 , , , cord-286607-5i406twr 103 26 and and CC cord-286607-5i406twr 103 27 TSST-1using tsst-1using NN cord-286607-5i406twr 103 28 polymerase polymerase NN cord-286607-5i406twr 103 29 chain chain NN cord-286607-5i406twr 103 30 reaction reaction NN cord-286607-5i406twr 103 31 ; ; : cord-286607-5i406twr 103 32 throat throat NN cord-286607-5i406twr 103 33 and and CC cord-286607-5i406twr 103 34 stool stool NN cord-286607-5i406twr 103 35 cultures culture NNS cord-286607-5i406twr 103 36 were be VBD cord-286607-5i406twr 103 37 assessed assess VBN cord-286607-5i406twr 103 38 to to TO cord-286607-5i406twr 103 39 evaluate evaluate VB cord-286607-5i406twr 103 40 the the DT cord-286607-5i406twr 103 41 presence presence NN cord-286607-5i406twr 103 42 of of IN cord-286607-5i406twr 103 43 Streptococcus streptococcus NN cord-286607-5i406twr 103 44 pyogenes pyogene NNS cord-286607-5i406twr 103 45 and and CC cord-286607-5i406twr 103 46 Staphylococcus Staphylococcus NNP cord-286607-5i406twr 103 47 aureus aureus NN cord-286607-5i406twr 103 48 in in IN cord-286607-5i406twr 103 49 KS KS NNP cord-286607-5i406twr 103 50 patients patient NNS cord-286607-5i406twr 103 51 . . . cord-286607-5i406twr 104 1 They -PRON- PRP cord-286607-5i406twr 104 2 reported report VBD cord-286607-5i406twr 104 3 that that IN cord-286607-5i406twr 104 4 at at RB cord-286607-5i406twr 104 5 least least RBS cord-286607-5i406twr 104 6 one one CD cord-286607-5i406twr 104 7 of of IN cord-286607-5i406twr 104 8 the the DT cord-286607-5i406twr 104 9 SAg SAg NNS cord-286607-5i406twr 104 10 - - HYPH cord-286607-5i406twr 104 11 related relate VBN cord-286607-5i406twr 104 12 genes gene NNS cord-286607-5i406twr 104 13 was be VBD cord-286607-5i406twr 104 14 detected detect VBN cord-286607-5i406twr 104 15 more more RBR cord-286607-5i406twr 104 16 frequently frequently RB cord-286607-5i406twr 104 17 in in IN cord-286607-5i406twr 104 18 the the DT cord-286607-5i406twr 104 19 stools stool NNS cord-286607-5i406twr 104 20 of of IN cord-286607-5i406twr 104 21 children child NNS cord-286607-5i406twr 104 22 with with IN cord-286607-5i406twr 104 23 KS KS NNP cord-286607-5i406twr 104 24 ( ( -LRB- cord-286607-5i406twr 104 25 78 78 CD cord-286607-5i406twr 104 26 ) ) -RRB- cord-286607-5i406twr 104 27 . . . cord-286607-5i406twr 105 1 Furthermore furthermore RB cord-286607-5i406twr 105 2 , , , cord-286607-5i406twr 105 3 among among IN cord-286607-5i406twr 105 4 358 358 CD cord-286607-5i406twr 105 5 patients patient NNS cord-286607-5i406twr 105 6 with with IN cord-286607-5i406twr 105 7 KS KS NNP cord-286607-5i406twr 105 8 , , , cord-286607-5i406twr 105 9 54 54 CD cord-286607-5i406twr 105 10 developed develop VBN cord-286607-5i406twr 105 11 concurrent concurrent JJ cord-286607-5i406twr 105 12 pneumonia pneumonia NN cord-286607-5i406twr 105 13 and and CC cord-286607-5i406twr 105 14 12 12 CD cord-286607-5i406twr 105 15 of of IN cord-286607-5i406twr 105 16 these these DT cord-286607-5i406twr 105 17 ( ( -LRB- cord-286607-5i406twr 105 18 22.2 22.2 CD cord-286607-5i406twr 105 19 % % NN cord-286607-5i406twr 105 20 ) ) -RRB- cord-286607-5i406twr 105 21 had have VBD cord-286607-5i406twr 105 22 high high JJ cord-286607-5i406twr 105 23 titers titer NNS cord-286607-5i406twr 105 24 of of IN cord-286607-5i406twr 105 25 anti anti JJ cord-286607-5i406twr 105 26 - - JJ cord-286607-5i406twr 105 27 Mycoplasma mycoplasma JJ cord-286607-5i406twr 105 28 pneumoniae pneumoniae NN cord-286607-5i406twr 105 29 antibody antibody NN cord-286607-5i406twr 105 30 ( ( -LRB- cord-286607-5i406twr 105 31 > > NFP cord-286607-5i406twr 105 32 1:640 1:640 CD cord-286607-5i406twr 105 33 ) ) -RRB- cord-286607-5i406twr 105 34 , , , cord-286607-5i406twr 105 35 suggesting suggest VBG cord-286607-5i406twr 105 36 a a DT cord-286607-5i406twr 105 37 potential potential JJ cord-286607-5i406twr 105 38 role role NN cord-286607-5i406twr 105 39 of of IN cord-286607-5i406twr 105 40 Mycoplasma Mycoplasma NNP cord-286607-5i406twr 105 41 pneumoniae pneumoniae NN cord-286607-5i406twr 105 42 in in IN cord-286607-5i406twr 105 43 KS KS NNP cord-286607-5i406twr 105 44 and and CC cord-286607-5i406twr 105 45 the the DT cord-286607-5i406twr 105 46 importance importance NN cord-286607-5i406twr 105 47 of of IN cord-286607-5i406twr 105 48 anti anti JJ cord-286607-5i406twr 105 49 - - JJ cord-286607-5i406twr 105 50 Mycoplasma mycoplasma JJ cord-286607-5i406twr 105 51 treatment treatment NN cord-286607-5i406twr 105 52 ( ( -LRB- cord-286607-5i406twr 105 53 79 79 CD cord-286607-5i406twr 105 54 ) ) -RRB- cord-286607-5i406twr 105 55 . . . cord-286607-5i406twr 106 1 Another another DT cord-286607-5i406twr 106 2 study study NN cord-286607-5i406twr 106 3 has have VBZ cord-286607-5i406twr 106 4 reported report VBN cord-286607-5i406twr 106 5 a a DT cord-286607-5i406twr 106 6 possible possible JJ cord-286607-5i406twr 106 7 role role NN cord-286607-5i406twr 106 8 of of IN cord-286607-5i406twr 106 9 fungal fungal JJ cord-286607-5i406twr 106 10 infections infection NNS cord-286607-5i406twr 106 11 in in IN cord-286607-5i406twr 106 12 the the DT cord-286607-5i406twr 106 13 development development NN cord-286607-5i406twr 106 14 of of IN cord-286607-5i406twr 106 15 KS KS NNP cord-286607-5i406twr 106 16 in in IN cord-286607-5i406twr 106 17 Japan Japan NNP cord-286607-5i406twr 106 18 , , , cord-286607-5i406twr 106 19 San San NNP cord-286607-5i406twr 106 20 Diego Diego NNP cord-286607-5i406twr 106 21 , , , cord-286607-5i406twr 106 22 and and CC cord-286607-5i406twr 106 23 the the DT cord-286607-5i406twr 106 24 island island NN cord-286607-5i406twr 106 25 of of IN cord-286607-5i406twr 106 26 Hawaii Hawaii NNP cord-286607-5i406twr 106 27 through through IN cord-286607-5i406twr 106 28 an an DT cord-286607-5i406twr 106 29 active active JJ cord-286607-5i406twr 106 30 role role NN cord-286607-5i406twr 106 31 of of IN cord-286607-5i406twr 106 32 tropospheric tropospheric JJ cord-286607-5i406twr 106 33 wind wind NN cord-286607-5i406twr 106 34 patterns pattern NNS cord-286607-5i406twr 106 35 leaving leave VBG cord-286607-5i406twr 106 36 from from IN cord-286607-5i406twr 106 37 Central Central NNP cord-286607-5i406twr 106 38 Asia Asia NNP cord-286607-5i406twr 106 39 , , , cord-286607-5i406twr 106 40 in in IN cord-286607-5i406twr 106 41 which which WDT cord-286607-5i406twr 106 42 toxins toxin NNS cord-286607-5i406twr 106 43 of of IN cord-286607-5i406twr 106 44 Candida Candida NNP cord-286607-5i406twr 106 45 species specie NNS cord-286607-5i406twr 106 46 are be VBP cord-286607-5i406twr 106 47 aerosolized aerosolize VBN cord-286607-5i406twr 106 48 ( ( -LRB- cord-286607-5i406twr 106 49 80 80 CD cord-286607-5i406twr 106 50 ) ) -RRB- cord-286607-5i406twr 106 51 . . . cord-286607-5i406twr 107 1 In in IN cord-286607-5i406twr 107 2 addition addition NN cord-286607-5i406twr 107 3 , , , cord-286607-5i406twr 107 4 due due IN cord-286607-5i406twr 107 5 to to IN cord-286607-5i406twr 107 6 the the DT cord-286607-5i406twr 107 7 observation observation NN cord-286607-5i406twr 107 8 that that IN cord-286607-5i406twr 107 9 Candida Candida NNP cord-286607-5i406twr 107 10 albicans albican NNS cord-286607-5i406twr 107 11 - - HYPH cord-286607-5i406twr 107 12 derived derive VBN cord-286607-5i406twr 107 13 substances substance NNS cord-286607-5i406twr 107 14 , , , cord-286607-5i406twr 107 15 such such JJ cord-286607-5i406twr 107 16 as as IN cord-286607-5i406twr 107 17 Candida Candida NNP cord-286607-5i406twr 107 18 albicans albican NNS cord-286607-5i406twr 107 19 watersoluble watersoluble JJ cord-286607-5i406twr 107 20 fraction fraction NN cord-286607-5i406twr 107 21 ( ( -LRB- cord-286607-5i406twr 107 22 CAWS CAWS NNP cord-286607-5i406twr 107 23 ) ) -RRB- cord-286607-5i406twr 107 24 , , , cord-286607-5i406twr 107 25 induce induce VB cord-286607-5i406twr 107 26 a a DT cord-286607-5i406twr 107 27 coronary coronary JJ cord-286607-5i406twr 107 28 arteritis arteritis NN cord-286607-5i406twr 107 29 in in IN cord-286607-5i406twr 107 30 mice mouse NNS cord-286607-5i406twr 107 31 similar similar JJ cord-286607-5i406twr 107 32 to to IN cord-286607-5i406twr 107 33 that that DT cord-286607-5i406twr 107 34 observed observe VBN cord-286607-5i406twr 107 35 in in IN cord-286607-5i406twr 107 36 KS KS NNP cord-286607-5i406twr 107 37 , , , cord-286607-5i406twr 107 38 Sato Sato NNP cord-286607-5i406twr 107 39 et et FW cord-286607-5i406twr 107 40 al al NNP cord-286607-5i406twr 107 41 . . NNP cord-286607-5i406twr 107 42 evaluated evaluate VBD cord-286607-5i406twr 107 43 the the DT cord-286607-5i406twr 107 44 role role NN cord-286607-5i406twr 107 45 of of IN cord-286607-5i406twr 107 46 a a DT cord-286607-5i406twr 107 47 free free JJ cord-286607-5i406twr 107 48 - - HYPH cord-286607-5i406twr 107 49 β β NN cord-286607-5i406twr 107 50 - - HYPH cord-286607-5i406twr 107 51 glucan glucan NN cord-286607-5i406twr 107 52 diet diet NN cord-286607-5i406twr 107 53 on on IN cord-286607-5i406twr 107 54 CAWS CAWS NNP cord-286607-5i406twr 107 55 - - HYPH cord-286607-5i406twr 107 56 induced induce VBN cord-286607-5i406twr 107 57 vasculitis vasculitis NN cord-286607-5i406twr 107 58 and and CC cord-286607-5i406twr 107 59 found find VBD cord-286607-5i406twr 107 60 that that IN cord-286607-5i406twr 107 61 quality quality NN cord-286607-5i406twr 107 62 of of IN cord-286607-5i406twr 107 63 diet diet NN cord-286607-5i406twr 107 64 might may MD cord-286607-5i406twr 107 65 affect affect VB cord-286607-5i406twr 107 66 the the DT cord-286607-5i406twr 107 67 progression progression NN cord-286607-5i406twr 107 68 of of IN cord-286607-5i406twr 107 69 systemic systemic JJ cord-286607-5i406twr 107 70 vasculitis vasculitis NN cord-286607-5i406twr 107 71 ( ( -LRB- cord-286607-5i406twr 107 72 81 81 CD cord-286607-5i406twr 107 73 ) ) -RRB- cord-286607-5i406twr 107 74 . . . cord-286607-5i406twr 108 1 CAWS CAWS NNP cord-286607-5i406twr 108 2 should should MD cord-286607-5i406twr 108 3 act act VB cord-286607-5i406twr 108 4 as as IN cord-286607-5i406twr 108 5 a a DT cord-286607-5i406twr 108 6 pathogen pathogen NN cord-286607-5i406twr 108 7 - - HYPH cord-286607-5i406twr 108 8 associated associate VBN cord-286607-5i406twr 108 9 molecular molecular JJ cord-286607-5i406twr 108 10 pattern pattern NN cord-286607-5i406twr 108 11 in in IN cord-286607-5i406twr 108 12 mice mouse NNS cord-286607-5i406twr 108 13 and and CC cord-286607-5i406twr 108 14 activate activate VB cord-286607-5i406twr 108 15 lectin lectin NN cord-286607-5i406twr 108 16 pathway pathway NN cord-286607-5i406twr 108 17 of of IN cord-286607-5i406twr 108 18 complement complement NN cord-286607-5i406twr 108 19 by by IN cord-286607-5i406twr 108 20 binding bind VBG cord-286607-5i406twr 108 21 to to IN cord-286607-5i406twr 108 22 mannose mannose NN cord-286607-5i406twr 108 23 - - HYPH cord-286607-5i406twr 108 24 binding bind VBG cord-286607-5i406twr 108 25 lectin lectin NN cord-286607-5i406twr 108 26 and and CC cord-286607-5i406twr 108 27 inducing induce VBG cord-286607-5i406twr 108 28 an an DT cord-286607-5i406twr 108 29 acute acute JJ cord-286607-5i406twr 108 30 inflammatory inflammatory JJ cord-286607-5i406twr 108 31 reaction reaction NN cord-286607-5i406twr 108 32 in in IN cord-286607-5i406twr 108 33 the the DT cord-286607-5i406twr 108 34 vascular vascular JJ cord-286607-5i406twr 108 35 system system NN cord-286607-5i406twr 108 36 ( ( -LRB- cord-286607-5i406twr 108 37 82 82 CD cord-286607-5i406twr 108 38 , , , cord-286607-5i406twr 108 39 83 83 CD cord-286607-5i406twr 108 40 ) ) -RRB- cord-286607-5i406twr 108 41 . . . cord-286607-5i406twr 109 1 There there EX cord-286607-5i406twr 109 2 are be VBP cord-286607-5i406twr 109 3 three three CD cord-286607-5i406twr 109 4 main main JJ cord-286607-5i406twr 109 5 reasons reason NNS cord-286607-5i406twr 109 6 that that WDT cord-286607-5i406twr 109 7 led lead VBD cord-286607-5i406twr 109 8 us -PRON- PRP cord-286607-5i406twr 109 9 to to TO cord-286607-5i406twr 109 10 postulate postulate VB cord-286607-5i406twr 109 11 a a DT cord-286607-5i406twr 109 12 role role NN cord-286607-5i406twr 109 13 of of IN cord-286607-5i406twr 109 14 the the DT cord-286607-5i406twr 109 15 microbiota microbiota NN cord-286607-5i406twr 109 16 in in IN cord-286607-5i406twr 109 17 KS KS NNP cord-286607-5i406twr 109 18 . . . cord-286607-5i406twr 110 1 The the DT cord-286607-5i406twr 110 2 first first JJ cord-286607-5i406twr 110 3 is be VBZ cord-286607-5i406twr 110 4 the the DT cord-286607-5i406twr 110 5 unsatisfactory unsatisfactory JJ cord-286607-5i406twr 110 6 microbiological microbiological JJ cord-286607-5i406twr 110 7 data datum NNS cord-286607-5i406twr 110 8 that that WDT cord-286607-5i406twr 110 9 limited limit VBD cord-286607-5i406twr 110 10 the the DT cord-286607-5i406twr 110 11 association association NN cord-286607-5i406twr 110 12 between between IN cord-286607-5i406twr 110 13 infections infection NNS cord-286607-5i406twr 110 14 and and CC cord-286607-5i406twr 110 15 KS KS NNP cord-286607-5i406twr 110 16 and and CC cord-286607-5i406twr 110 17 a a DT cord-286607-5i406twr 110 18 lack lack NN cord-286607-5i406twr 110 19 of of IN cord-286607-5i406twr 110 20 evidence evidence NN cord-286607-5i406twr 110 21 of of IN cord-286607-5i406twr 110 22 any any DT cord-286607-5i406twr 110 23 clear clear JJ cord-286607-5i406twr 110 24 relationship relationship NN cord-286607-5i406twr 110 25 between between IN cord-286607-5i406twr 110 26 one one CD cord-286607-5i406twr 110 27 or or CC cord-286607-5i406twr 110 28 more more JJR cord-286607-5i406twr 110 29 pathogens pathogen NNS cord-286607-5i406twr 110 30 with with IN cord-286607-5i406twr 110 31 this this DT cord-286607-5i406twr 110 32 illness illness NN cord-286607-5i406twr 110 33 . . . cord-286607-5i406twr 111 1 Second second RB cord-286607-5i406twr 111 2 , , , cord-286607-5i406twr 111 3 the the DT cord-286607-5i406twr 111 4 most most RBS cord-286607-5i406twr 111 5 frequent frequent JJ cord-286607-5i406twr 111 6 bacteria bacteria NNS cord-286607-5i406twr 111 7 or or CC cord-286607-5i406twr 111 8 viruses virus NNS cord-286607-5i406twr 111 9 associated associate VBN cord-286607-5i406twr 111 10 with with IN cord-286607-5i406twr 111 11 KS KS NNP cord-286607-5i406twr 111 12 have have VBP cord-286607-5i406twr 111 13 a a DT cord-286607-5i406twr 111 14 higher high JJR cord-286607-5i406twr 111 15 prevalence prevalence NN cord-286607-5i406twr 111 16 in in IN cord-286607-5i406twr 111 17 the the DT cord-286607-5i406twr 111 18 overall overall JJ cord-286607-5i406twr 111 19 pediatric pediatric JJ cord-286607-5i406twr 111 20 population population NN cord-286607-5i406twr 111 21 , , , cord-286607-5i406twr 111 22 but but CC cord-286607-5i406twr 111 23 only only RB cord-286607-5i406twr 111 24 a a DT cord-286607-5i406twr 111 25 limited limited JJ cord-286607-5i406twr 111 26 number number NN cord-286607-5i406twr 111 27 of of IN cord-286607-5i406twr 111 28 children child NNS cord-286607-5i406twr 111 29 will will MD cord-286607-5i406twr 111 30 develop develop VB cord-286607-5i406twr 111 31 the the DT cord-286607-5i406twr 111 32 disease disease NN cord-286607-5i406twr 111 33 . . . cord-286607-5i406twr 112 1 Third third RB cord-286607-5i406twr 112 2 , , , cord-286607-5i406twr 112 3 the the DT cord-286607-5i406twr 112 4 association association NN cord-286607-5i406twr 112 5 of of IN cord-286607-5i406twr 112 6 genetic genetic JJ cord-286607-5i406twr 112 7 predisposition predisposition NN cord-286607-5i406twr 112 8 and and CC cord-286607-5i406twr 112 9 environmental environmental JJ cord-286607-5i406twr 112 10 factors factor NNS cord-286607-5i406twr 112 11 in in IN cord-286607-5i406twr 112 12 the the DT cord-286607-5i406twr 112 13 pathogenetic pathogenetic JJ cord-286607-5i406twr 112 14 process process NN cord-286607-5i406twr 112 15 of of IN cord-286607-5i406twr 112 16 KS KS NNP cord-286607-5i406twr 112 17 makes make VBZ cord-286607-5i406twr 112 18 KS KS NNP cord-286607-5i406twr 112 19 itself -PRON- PRP cord-286607-5i406twr 112 20 similar similar JJ cord-286607-5i406twr 112 21 to to IN cord-286607-5i406twr 112 22 other other JJ cord-286607-5i406twr 112 23 multifactorial multifactorial JJ cord-286607-5i406twr 112 24 diseases disease NNS cord-286607-5i406twr 112 25 . . . cord-286607-5i406twr 113 1 Currently currently RB cord-286607-5i406twr 113 2 , , , cord-286607-5i406twr 113 3 the the DT cord-286607-5i406twr 113 4 majority majority NN cord-286607-5i406twr 113 5 of of IN cord-286607-5i406twr 113 6 data datum NNS cord-286607-5i406twr 113 7 has have VBZ cord-286607-5i406twr 113 8 found find VBN cord-286607-5i406twr 113 9 that that IN cord-286607-5i406twr 113 10 the the DT cord-286607-5i406twr 113 11 composition composition NN cord-286607-5i406twr 113 12 of of IN cord-286607-5i406twr 113 13 the the DT cord-286607-5i406twr 113 14 gut gut NN cord-286607-5i406twr 113 15 microbiota microbiota NN cord-286607-5i406twr 113 16 in in IN cord-286607-5i406twr 113 17 KS KS NNP cord-286607-5i406twr 113 18 patients patient NNS cord-286607-5i406twr 113 19 differs differ VBZ cord-286607-5i406twr 113 20 from from IN cord-286607-5i406twr 113 21 healthy healthy JJ cord-286607-5i406twr 113 22 subjects subject NNS cord-286607-5i406twr 113 23 . . . cord-286607-5i406twr 114 1 Lee Lee NNP cord-286607-5i406twr 114 2 et et NNP cord-286607-5i406twr 114 3 al al NNP cord-286607-5i406twr 114 4 . . NNP cord-286607-5i406twr 114 5 have have VBP cord-286607-5i406twr 114 6 postulated postulate VBN cord-286607-5i406twr 114 7 that that IN cord-286607-5i406twr 114 8 the the DT cord-286607-5i406twr 114 9 immune immune JJ cord-286607-5i406twr 114 10 system system NN cord-286607-5i406twr 114 11 should should MD cord-286607-5i406twr 114 12 lose lose VB cord-286607-5i406twr 114 13 tolerance tolerance NN cord-286607-5i406twr 114 14 toward toward IN cord-286607-5i406twr 114 15 a a DT cord-286607-5i406twr 114 16 part part NN cord-286607-5i406twr 114 17 of of IN cord-286607-5i406twr 114 18 the the DT cord-286607-5i406twr 114 19 resident resident JJ cord-286607-5i406twr 114 20 intestinal intestinal JJ cord-286607-5i406twr 114 21 flora flora NNS cord-286607-5i406twr 114 22 and and CC cord-286607-5i406twr 114 23 that that IN cord-286607-5i406twr 114 24 environmental environmental JJ cord-286607-5i406twr 114 25 factors factor NNS cord-286607-5i406twr 114 26 , , , cord-286607-5i406twr 114 27 i.e. i.e. FW cord-286607-5i406twr 114 28 , , , cord-286607-5i406twr 114 29 a a DT cord-286607-5i406twr 114 30 Western western JJ cord-286607-5i406twr 114 31 lifestyle lifestyle NN cord-286607-5i406twr 114 32 or or CC cord-286607-5i406twr 114 33 improved improve VBN cord-286607-5i406twr 114 34 public public JJ cord-286607-5i406twr 114 35 hygiene hygiene NN cord-286607-5i406twr 114 36 systems system NNS cord-286607-5i406twr 114 37 , , , cord-286607-5i406twr 114 38 could could MD cord-286607-5i406twr 114 39 transform transform VB cord-286607-5i406twr 114 40 the the DT cord-286607-5i406twr 114 41 commensal commensal JJ cord-286607-5i406twr 114 42 flora flora NNS cord-286607-5i406twr 114 43 into into IN cord-286607-5i406twr 114 44 a a DT cord-286607-5i406twr 114 45 pathogen pathogen NN cord-286607-5i406twr 114 46 one one NN cord-286607-5i406twr 114 47 , , , cord-286607-5i406twr 114 48 as as IN cord-286607-5i406twr 114 49 observed observe VBN cord-286607-5i406twr 114 50 in in IN cord-286607-5i406twr 114 51 different different JJ cord-286607-5i406twr 114 52 gastrointestinal gastrointestinal JJ cord-286607-5i406twr 114 53 disorders disorder NNS cord-286607-5i406twr 114 54 ( ( -LRB- cord-286607-5i406twr 114 55 84 84 CD cord-286607-5i406twr 114 56 ) ) -RRB- cord-286607-5i406twr 114 57 . . . cord-286607-5i406twr 115 1 A a DT cord-286607-5i406twr 115 2 recent recent JJ cord-286607-5i406twr 115 3 study study NN cord-286607-5i406twr 115 4 about about IN cord-286607-5i406twr 115 5 the the DT cord-286607-5i406twr 115 6 resident resident JJ cord-286607-5i406twr 115 7 flora flora NNS cord-286607-5i406twr 115 8 and and CC cord-286607-5i406twr 115 9 KS KS NNP cord-286607-5i406twr 115 10 was be VBD cord-286607-5i406twr 115 11 focused focus VBN cord-286607-5i406twr 115 12 on on IN cord-286607-5i406twr 115 13 throat throat NN cord-286607-5i406twr 115 14 flora flora NNS cord-286607-5i406twr 115 15 . . . cord-286607-5i406twr 116 1 Horita Horita NNP cord-286607-5i406twr 116 2 et et NNP cord-286607-5i406twr 116 3 al al NNP cord-286607-5i406twr 116 4 . . . cord-286607-5i406twr 117 1 ( ( -LRB- cord-286607-5i406twr 117 2 85 85 CD cord-286607-5i406twr 117 3 ) ) -RRB- cord-286607-5i406twr 117 4 assumed assume VBD cord-286607-5i406twr 117 5 that that IN cord-286607-5i406twr 117 6 throat throat NN cord-286607-5i406twr 117 7 flora flora NNS cord-286607-5i406twr 117 8 could could MD cord-286607-5i406twr 117 9 be be VB cord-286607-5i406twr 117 10 a a DT cord-286607-5i406twr 117 11 reservoir reservoir NN cord-286607-5i406twr 117 12 of of IN cord-286607-5i406twr 117 13 microorganisms microorganism NNS cord-286607-5i406twr 117 14 triggering trigger VBG cord-286607-5i406twr 117 15 KS KS NNP cord-286607-5i406twr 117 16 and and CC cord-286607-5i406twr 117 17 , , , cord-286607-5i406twr 117 18 following follow VBG cord-286607-5i406twr 117 19 this this DT cord-286607-5i406twr 117 20 hypothesis hypothesis NN cord-286607-5i406twr 117 21 , , , cord-286607-5i406twr 117 22 they -PRON- PRP cord-286607-5i406twr 117 23 investigated investigate VBD cord-286607-5i406twr 117 24 throat throat NN cord-286607-5i406twr 117 25 microorganisms microorganism NNS cord-286607-5i406twr 117 26 of of IN cord-286607-5i406twr 117 27 KS KS NNP cord-286607-5i406twr 117 28 patients patient NNS cord-286607-5i406twr 117 29 for for IN cord-286607-5i406twr 117 30 their -PRON- PRP$ cord-286607-5i406twr 117 31 content content NN cord-286607-5i406twr 117 32 and and CC cord-286607-5i406twr 117 33 individual individual JJ cord-286607-5i406twr 117 34 SAg SAg NNS cord-286607-5i406twr 117 35 activity activity NN cord-286607-5i406twr 117 36 . . . cord-286607-5i406twr 118 1 In in IN cord-286607-5i406twr 118 2 particular particular JJ cord-286607-5i406twr 118 3 , , , cord-286607-5i406twr 118 4 they -PRON- PRP cord-286607-5i406twr 118 5 collected collect VBD cord-286607-5i406twr 118 6 throat throat NN cord-286607-5i406twr 118 7 swabs swab NNS cord-286607-5i406twr 118 8 at at IN cord-286607-5i406twr 118 9 the the DT cord-286607-5i406twr 118 10 start start NN cord-286607-5i406twr 118 11 of of IN cord-286607-5i406twr 118 12 IVIG IVIG NNP cord-286607-5i406twr 118 13 infusion infusion NN cord-286607-5i406twr 118 14 in in IN cord-286607-5i406twr 118 15 21 21 CD cord-286607-5i406twr 118 16 KS KS NNP cord-286607-5i406twr 118 17 patients patient NNS cord-286607-5i406twr 118 18 and and CC cord-286607-5i406twr 118 19 compared compare VBD cord-286607-5i406twr 118 20 them -PRON- PRP cord-286607-5i406twr 118 21 with with IN cord-286607-5i406twr 118 22 non non JJ cord-286607-5i406twr 118 23 - - JJ cord-286607-5i406twr 118 24 KS KS NNP cord-286607-5i406twr 118 25 controls control NNS cord-286607-5i406twr 118 26 ( ( -LRB- cord-286607-5i406twr 118 27 displaying display VBG cord-286607-5i406twr 118 28 other other JJ cord-286607-5i406twr 118 29 febrile febrile JJ cord-286607-5i406twr 118 30 illnesses illness NNS cord-286607-5i406twr 118 31 ) ) -RRB- cord-286607-5i406twr 118 32 . . . cord-286607-5i406twr 119 1 The the DT cord-286607-5i406twr 119 2 results result NNS cord-286607-5i406twr 119 3 showed show VBD cord-286607-5i406twr 119 4 no no DT cord-286607-5i406twr 119 5 difference difference NN cord-286607-5i406twr 119 6 in in IN cord-286607-5i406twr 119 7 the the DT cord-286607-5i406twr 119 8 throat throat NN cord-286607-5i406twr 119 9 flora flora NNS cord-286607-5i406twr 119 10 between between IN cord-286607-5i406twr 119 11 KS KS NNP cord-286607-5i406twr 119 12 and and CC cord-286607-5i406twr 119 13 febrile febrile JJ cord-286607-5i406twr 119 14 controls control NNS cord-286607-5i406twr 119 15 even even RB cord-286607-5i406twr 119 16 in in IN cord-286607-5i406twr 119 17 the the DT cord-286607-5i406twr 119 18 mean mean JJ cord-286607-5i406twr 119 19 mitogenic mitogenic JJ cord-286607-5i406twr 119 20 activity activity NN cord-286607-5i406twr 119 21 of of IN cord-286607-5i406twr 119 22 bacteria bacteria NNS cord-286607-5i406twr 119 23 isolated isolate VBN cord-286607-5i406twr 119 24 ( ( -LRB- cord-286607-5i406twr 119 25 85 85 CD cord-286607-5i406twr 119 26 ) ) -RRB- cord-286607-5i406twr 119 27 . . . cord-286607-5i406twr 120 1 The the DT cord-286607-5i406twr 120 2 gastrointestinal gastrointestinal JJ cord-286607-5i406twr 120 3 tract tract NN cord-286607-5i406twr 120 4 could could MD cord-286607-5i406twr 120 5 be be VB cord-286607-5i406twr 120 6 one one CD cord-286607-5i406twr 120 7 of of IN cord-286607-5i406twr 120 8 the the DT cord-286607-5i406twr 120 9 primary primary JJ cord-286607-5i406twr 120 10 sites site NNS cord-286607-5i406twr 120 11 of of IN cord-286607-5i406twr 120 12 entry entry NN cord-286607-5i406twr 120 13 of of IN cord-286607-5i406twr 120 14 bacterial bacterial JJ cord-286607-5i406twr 120 15 toxins toxin NNS cord-286607-5i406twr 120 16 in in IN cord-286607-5i406twr 120 17 children child NNS cord-286607-5i406twr 120 18 with with IN cord-286607-5i406twr 120 19 KS KS NNP cord-286607-5i406twr 120 20 , , , cord-286607-5i406twr 120 21 and and CC cord-286607-5i406twr 120 22 a a DT cord-286607-5i406twr 120 23 perturbation perturbation NN cord-286607-5i406twr 120 24 in in IN cord-286607-5i406twr 120 25 the the DT cord-286607-5i406twr 120 26 intestinal intestinal JJ cord-286607-5i406twr 120 27 microbiota microbiota NN cord-286607-5i406twr 120 28 has have VBZ cord-286607-5i406twr 120 29 been be VBN cord-286607-5i406twr 120 30 linked link VBN cord-286607-5i406twr 120 31 to to IN cord-286607-5i406twr 120 32 the the DT cord-286607-5i406twr 120 33 disease disease NN cord-286607-5i406twr 120 34 's 's POS cord-286607-5i406twr 120 35 pathophysiology pathophysiology NN cord-286607-5i406twr 120 36 in in IN cord-286607-5i406twr 120 37 another another DT cord-286607-5i406twr 120 38 study study NN cord-286607-5i406twr 120 39 by by IN cord-286607-5i406twr 120 40 Yamashiro Yamashiro NNP cord-286607-5i406twr 120 41 et et FW cord-286607-5i406twr 120 42 al al NNP cord-286607-5i406twr 120 43 . . . cord-286607-5i406twr 121 1 ( ( -LRB- cord-286607-5i406twr 121 2 86 86 CD cord-286607-5i406twr 121 3 ) ) -RRB- cord-286607-5i406twr 121 4 who who WP cord-286607-5i406twr 121 5 investigated investigate VBD cord-286607-5i406twr 121 6 the the DT cord-286607-5i406twr 121 7 microflora microflora NN cord-286607-5i406twr 121 8 of of IN cord-286607-5i406twr 121 9 the the DT cord-286607-5i406twr 121 10 small small JJ cord-286607-5i406twr 121 11 intestine intestine NN cord-286607-5i406twr 121 12 in in IN cord-286607-5i406twr 121 13 15 15 CD cord-286607-5i406twr 121 14 Japanese japanese JJ cord-286607-5i406twr 121 15 patients patient NNS cord-286607-5i406twr 121 16 with with IN cord-286607-5i406twr 121 17 KS KS NNP cord-286607-5i406twr 121 18 . . . cord-286607-5i406twr 122 1 The the DT cord-286607-5i406twr 122 2 range range NN cord-286607-5i406twr 122 3 of of IN cord-286607-5i406twr 122 4 bacterial bacterial JJ cord-286607-5i406twr 122 5 species specie NNS cord-286607-5i406twr 122 6 isolated isolate VBN cord-286607-5i406twr 122 7 from from IN cord-286607-5i406twr 122 8 jejunal jejunal JJ cord-286607-5i406twr 122 9 biopsies biopsy NNS cord-286607-5i406twr 122 10 was be VBD cord-286607-5i406twr 122 11 characterized characterize VBN cord-286607-5i406twr 122 12 by by IN cord-286607-5i406twr 122 13 a a DT cord-286607-5i406twr 122 14 wider wide JJR cord-286607-5i406twr 122 15 variety variety NN cord-286607-5i406twr 122 16 of of IN cord-286607-5i406twr 122 17 Gram gram NN cord-286607-5i406twr 122 18 - - HYPH cord-286607-5i406twr 122 19 positive positive JJ cord-286607-5i406twr 122 20 cocci coccus NNS cord-286607-5i406twr 122 21 in in IN cord-286607-5i406twr 122 22 the the DT cord-286607-5i406twr 122 23 acute acute JJ cord-286607-5i406twr 122 24 phase phase NN cord-286607-5i406twr 122 25 of of IN cord-286607-5i406twr 122 26 KS KS NNP cord-286607-5i406twr 122 27 . . . cord-286607-5i406twr 123 1 Notably notably RB cord-286607-5i406twr 123 2 , , , cord-286607-5i406twr 123 3 5 5 CD cord-286607-5i406twr 123 4 kinds kind NNS cord-286607-5i406twr 123 5 of of IN cord-286607-5i406twr 123 6 streptococci streptococcus NNS cord-286607-5i406twr 123 7 ( ( -LRB- cord-286607-5i406twr 123 8 Streptococcus streptococcus NN cord-286607-5i406twr 123 9 salivarius salivarius NN cord-286607-5i406twr 123 10 , , , cord-286607-5i406twr 123 11 Streptococcus Streptococcus NNP cord-286607-5i406twr 123 12 mitis mitis NN cord-286607-5i406twr 123 13 , , , cord-286607-5i406twr 123 14 Streptococcus Streptococcus NNP cord-286607-5i406twr 123 15 oralis oralis NNP cord-286607-5i406twr 123 16 , , , cord-286607-5i406twr 123 17 Streptococcus Streptococcus NNP cord-286607-5i406twr 123 18 sangius sangius NN cord-286607-5i406twr 123 19 , , , cord-286607-5i406twr 123 20 and and CC cord-286607-5i406twr 123 21 Gemella Gemella NNP cord-286607-5i406twr 123 22 haemolysans haemolysans NNPS cord-286607-5i406twr 123 23 ) ) -RRB- cord-286607-5i406twr 123 24 and and CC cord-286607-5i406twr 123 25 2 2 CD cord-286607-5i406twr 123 26 kinds kind NNS cord-286607-5i406twr 123 27 of of IN cord-286607-5i406twr 123 28 staphylococci staphylococcus NNS cord-286607-5i406twr 123 29 ( ( -LRB- cord-286607-5i406twr 123 30 Staphylococcus Staphylococcus NNP cord-286607-5i406twr 123 31 capitis capitis NN cord-286607-5i406twr 123 32 and and CC cord-286607-5i406twr 123 33 Staphylococcus Staphylococcus NNP cord-286607-5i406twr 123 34 hyicus hyicus NNP cord-286607-5i406twr 123 35 ) ) -RRB- cord-286607-5i406twr 123 36 were be VBD cord-286607-5i406twr 123 37 isolated isolate VBN cord-286607-5i406twr 123 38 only only RB cord-286607-5i406twr 123 39 from from IN cord-286607-5i406twr 123 40 KS KS NNP cord-286607-5i406twr 123 41 patients patient NNS cord-286607-5i406twr 123 42 , , , cord-286607-5i406twr 123 43 suggesting suggest VBG cord-286607-5i406twr 123 44 that that IN cord-286607-5i406twr 123 45 some some DT cord-286607-5i406twr 123 46 antigens antigen NNS cord-286607-5i406twr 123 47 inducing induce VBG cord-286607-5i406twr 123 48 a a DT cord-286607-5i406twr 123 49 delayed delay VBN cord-286607-5i406twr 123 50 - - HYPH cord-286607-5i406twr 123 51 type type NN cord-286607-5i406twr 123 52 hypersensitivity hypersensitivity NN cord-286607-5i406twr 123 53 reaction reaction NN cord-286607-5i406twr 123 54 in in IN cord-286607-5i406twr 123 55 the the DT cord-286607-5i406twr 123 56 mucosa mucosa NN cord-286607-5i406twr 123 57 might may MD cord-286607-5i406twr 123 58 inundate inundate VB cord-286607-5i406twr 123 59 the the DT cord-286607-5i406twr 123 60 body body NN cord-286607-5i406twr 123 61 by by IN cord-286607-5i406twr 123 62 breaching breach VBG cord-286607-5i406twr 123 63 the the DT cord-286607-5i406twr 123 64 barrier barrier NN cord-286607-5i406twr 123 65 of of IN cord-286607-5i406twr 123 66 the the DT cord-286607-5i406twr 123 67 small small JJ cord-286607-5i406twr 123 68 intestinal intestinal JJ cord-286607-5i406twr 123 69 mucosa mucosa NN cord-286607-5i406twr 123 70 of of IN cord-286607-5i406twr 123 71 KS KS NNP cord-286607-5i406twr 123 72 patients patient NNS cord-286607-5i406twr 123 73 ( ( -LRB- cord-286607-5i406twr 123 74 86 86 CD cord-286607-5i406twr 123 75 ) ) -RRB- cord-286607-5i406twr 123 76 . . . cord-286607-5i406twr 124 1 In in IN cord-286607-5i406twr 124 2 fact fact NN cord-286607-5i406twr 124 3 , , , cord-286607-5i406twr 124 4 Nagata Nagata NNP cord-286607-5i406twr 124 5 et et NNP cord-286607-5i406twr 124 6 al al NNP cord-286607-5i406twr 124 7 . . . cord-286607-5i406twr 125 1 ( ( -LRB- cord-286607-5i406twr 125 2 87 87 CD cord-286607-5i406twr 125 3 ) ) -RRB- cord-286607-5i406twr 125 4 investigated investigate VBN cord-286607-5i406twr 125 5 cell cell NN cord-286607-5i406twr 125 6 surface surface NN cord-286607-5i406twr 125 7 phenotypes phenotype NNS cord-286607-5i406twr 125 8 of of IN cord-286607-5i406twr 125 9 mononuclear mononuclear JJ cord-286607-5i406twr 125 10 cells cell NNS cord-286607-5i406twr 125 11 and and CC cord-286607-5i406twr 125 12 enterocytes enterocyte NNS cord-286607-5i406twr 125 13 in in IN cord-286607-5i406twr 125 14 the the DT cord-286607-5i406twr 125 15 jejunal jejunal JJ cord-286607-5i406twr 125 16 mucosa mucosa NN cord-286607-5i406twr 125 17 of of IN cord-286607-5i406twr 125 18 16 16 CD cord-286607-5i406twr 125 19 Japanese japanese JJ cord-286607-5i406twr 125 20 patients patient NNS cord-286607-5i406twr 125 21 with with IN cord-286607-5i406twr 125 22 KS KS NNP cord-286607-5i406twr 125 23 and and CC cord-286607-5i406twr 125 24 in in IN cord-286607-5i406twr 125 25 10 10 CD cord-286607-5i406twr 125 26 patients patient NNS cord-286607-5i406twr 125 27 with with IN cord-286607-5i406twr 125 28 diarrhea diarrhea NN cord-286607-5i406twr 125 29 due due IN cord-286607-5i406twr 125 30 to to IN cord-286607-5i406twr 125 31 cow cow NN cord-286607-5i406twr 125 32 's 's POS cord-286607-5i406twr 125 33 milk milk NN cord-286607-5i406twr 125 34 protein protein NN cord-286607-5i406twr 125 35 intolerance intolerance NN cord-286607-5i406twr 125 36 . . . cord-286607-5i406twr 126 1 Both both DT cord-286607-5i406twr 126 2 HLA HLA NNP cord-286607-5i406twr 126 3 - - HYPH cord-286607-5i406twr 126 4 DR+CD3 dr+cd3 NN cord-286607-5i406twr 126 5 + + CC cord-286607-5i406twr 126 6 and and CC cord-286607-5i406twr 126 7 DR+CD4 DR+CD4 NNS cord-286607-5i406twr 126 8 + + CC cord-286607-5i406twr 126 9 cells cell NNS cord-286607-5i406twr 126 10 were be VBD cord-286607-5i406twr 126 11 significantly significantly RB cord-286607-5i406twr 126 12 increased increase VBN cord-286607-5i406twr 126 13 , , , cord-286607-5i406twr 126 14 and and CC cord-286607-5i406twr 126 15 CD8 CD8 NNP cord-286607-5i406twr 126 16 + + CC cord-286607-5i406twr 126 17 cells cell NNS cord-286607-5i406twr 126 18 significantly significantly RB cord-286607-5i406twr 126 19 reduced reduce VBN cord-286607-5i406twr 126 20 in in IN cord-286607-5i406twr 126 21 the the DT cord-286607-5i406twr 126 22 lamina lamina JJ cord-286607-5i406twr 126 23 propria propria NN cord-286607-5i406twr 126 24 of of IN cord-286607-5i406twr 126 25 KS KS NNP cord-286607-5i406twr 126 26 patients patient NNS cord-286607-5i406twr 126 27 during during IN cord-286607-5i406twr 126 28 the the DT cord-286607-5i406twr 126 29 acute acute JJ cord-286607-5i406twr 126 30 phase phase NN cord-286607-5i406twr 126 31 compared compare VBN cord-286607-5i406twr 126 32 with with IN cord-286607-5i406twr 126 33 patients patient NNS cord-286607-5i406twr 126 34 with with IN cord-286607-5i406twr 126 35 cow cow NN cord-286607-5i406twr 126 36 's 's POS cord-286607-5i406twr 126 37 milk milk NN cord-286607-5i406twr 126 38 protein protein NN cord-286607-5i406twr 126 39 intolerance intolerance NN cord-286607-5i406twr 126 40 . . . cord-286607-5i406twr 127 1 These these DT cord-286607-5i406twr 127 2 cell cell NN cord-286607-5i406twr 127 3 patterns pattern NNS cord-286607-5i406twr 127 4 returned return VBD cord-286607-5i406twr 127 5 to to IN cord-286607-5i406twr 127 6 normal normal JJ cord-286607-5i406twr 127 7 in in IN cord-286607-5i406twr 127 8 the the DT cord-286607-5i406twr 127 9 convalescent convalescent JJ cord-286607-5i406twr 127 10 phase phase NN cord-286607-5i406twr 127 11 of of IN cord-286607-5i406twr 127 12 KS KS NNP cord-286607-5i406twr 127 13 . . . cord-286607-5i406twr 128 1 The the DT cord-286607-5i406twr 128 2 authors author NNS cord-286607-5i406twr 128 3 concluded conclude VBD cord-286607-5i406twr 128 4 that that IN cord-286607-5i406twr 128 5 a a DT cord-286607-5i406twr 128 6 delayed delay VBN cord-286607-5i406twr 128 7 - - HYPH cord-286607-5i406twr 128 8 type type NN cord-286607-5i406twr 128 9 hypersensitivity hypersensitivity NN cord-286607-5i406twr 128 10 reaction reaction NN cord-286607-5i406twr 128 11 was be VBD cord-286607-5i406twr 128 12 indeed indeed RB cord-286607-5i406twr 128 13 present present JJ cord-286607-5i406twr 128 14 in in IN cord-286607-5i406twr 128 15 the the DT cord-286607-5i406twr 128 16 small small JJ cord-286607-5i406twr 128 17 intestinal intestinal JJ cord-286607-5i406twr 128 18 mucosa mucosa NN cord-286607-5i406twr 128 19 of of IN cord-286607-5i406twr 128 20 KS KS NNP cord-286607-5i406twr 128 21 patients patient NNS cord-286607-5i406twr 128 22 ( ( -LRB- cord-286607-5i406twr 128 23 87 87 CD cord-286607-5i406twr 128 24 ) ) -RRB- cord-286607-5i406twr 128 25 . . . cord-286607-5i406twr 129 1 Due due IN cord-286607-5i406twr 129 2 to to IN cord-286607-5i406twr 129 3 the the DT cord-286607-5i406twr 129 4 fact fact NN cord-286607-5i406twr 129 5 that that IN cord-286607-5i406twr 129 6 the the DT cord-286607-5i406twr 129 7 gastrointestinal gastrointestinal JJ cord-286607-5i406twr 129 8 tract tract NN cord-286607-5i406twr 129 9 is be VBZ cord-286607-5i406twr 129 10 the the DT cord-286607-5i406twr 129 11 largest large JJS cord-286607-5i406twr 129 12 interface interface NN cord-286607-5i406twr 129 13 between between IN cord-286607-5i406twr 129 14 microbial microbial JJ cord-286607-5i406twr 129 15 factors factor NNS cord-286607-5i406twr 129 16 and and CC cord-286607-5i406twr 129 17 their -PRON- PRP$ cord-286607-5i406twr 129 18 host host NN cord-286607-5i406twr 129 19 , , , cord-286607-5i406twr 129 20 containing contain VBG cord-286607-5i406twr 129 21 the the DT cord-286607-5i406twr 129 22 largest large JJS cord-286607-5i406twr 129 23 proportion proportion NN cord-286607-5i406twr 129 24 of of IN cord-286607-5i406twr 129 25 bacteria bacteria NNS cord-286607-5i406twr 129 26 and and CC cord-286607-5i406twr 129 27 the the DT cord-286607-5i406twr 129 28 largest large JJS cord-286607-5i406twr 129 29 amount amount NN cord-286607-5i406twr 129 30 of of IN cord-286607-5i406twr 129 31 lymphoid lymphoid JJ cord-286607-5i406twr 129 32 tissue tissue NN cord-286607-5i406twr 129 33 in in IN cord-286607-5i406twr 129 34 the the DT cord-286607-5i406twr 129 35 body body NN cord-286607-5i406twr 129 36 , , , cord-286607-5i406twr 129 37 it -PRON- PRP cord-286607-5i406twr 129 38 was be VBD cord-286607-5i406twr 129 39 hypothesized hypothesize VBN cord-286607-5i406twr 129 40 by by IN cord-286607-5i406twr 129 41 Eladawy Eladawy NNP cord-286607-5i406twr 129 42 et et NNP cord-286607-5i406twr 129 43 al al NNP cord-286607-5i406twr 129 44 . . . cord-286607-5i406twr 130 1 that that IN cord-286607-5i406twr 130 2 the the DT cord-286607-5i406twr 130 3 intestinal intestinal JJ cord-286607-5i406twr 130 4 milieu milieu NN cord-286607-5i406twr 130 5 could could MD cord-286607-5i406twr 130 6 be be VB cord-286607-5i406twr 130 7 altered alter VBN cord-286607-5i406twr 130 8 in in IN cord-286607-5i406twr 130 9 children child NNS cord-286607-5i406twr 130 10 with with IN cord-286607-5i406twr 130 11 KS KS NNP cord-286607-5i406twr 130 12 , , , cord-286607-5i406twr 130 13 and and CC cord-286607-5i406twr 130 14 indeed indeed RB cord-286607-5i406twr 130 15 KS KS NNP cord-286607-5i406twr 130 16 patients patient NNS cord-286607-5i406twr 130 17 have have VBP cord-286607-5i406twr 130 18 a a DT cord-286607-5i406twr 130 19 higher high JJR cord-286607-5i406twr 130 20 incidence incidence NN cord-286607-5i406twr 130 21 of of IN cord-286607-5i406twr 130 22 gastrointestinal gastrointestinal JJ cord-286607-5i406twr 130 23 symptoms symptom NNS cord-286607-5i406twr 130 24 and and CC cord-286607-5i406twr 130 25 complications complication NNS cord-286607-5i406twr 130 26 ( ( -LRB- cord-286607-5i406twr 130 27 88 88 CD cord-286607-5i406twr 130 28 ) ) -RRB- cord-286607-5i406twr 130 29 . . . cord-286607-5i406twr 131 1 Specifically specifically RB cord-286607-5i406twr 131 2 , , , cord-286607-5i406twr 131 3 Takeshita Takeshita NNP cord-286607-5i406twr 131 4 et et NNP cord-286607-5i406twr 131 5 al al NNP cord-286607-5i406twr 131 6 . . . cord-286607-5i406twr 132 1 ( ( -LRB- cord-286607-5i406twr 132 2 89 89 CD cord-286607-5i406twr 132 3 ) ) -RRB- cord-286607-5i406twr 132 4 evaluated evaluate VBD cord-286607-5i406twr 132 5 20 20 CD cord-286607-5i406twr 132 6 patients patient NNS cord-286607-5i406twr 132 7 with with IN cord-286607-5i406twr 132 8 KS KS NNP cord-286607-5i406twr 132 9 , , , cord-286607-5i406twr 132 10 20 20 CD cord-286607-5i406twr 132 11 patients patient NNS cord-286607-5i406twr 132 12 with with IN cord-286607-5i406twr 132 13 acute acute JJ cord-286607-5i406twr 132 14 febrile febrile JJ cord-286607-5i406twr 132 15 diseases disease NNS cord-286607-5i406twr 132 16 and and CC cord-286607-5i406twr 132 17 20 20 CD cord-286607-5i406twr 132 18 healthy healthy JJ cord-286607-5i406twr 132 19 children child NNS cord-286607-5i406twr 132 20 , , , cord-286607-5i406twr 132 21 finding find VBG cord-286607-5i406twr 132 22 that that IN cord-286607-5i406twr 132 23 the the DT cord-286607-5i406twr 132 24 incidence incidence NN cord-286607-5i406twr 132 25 of of IN cord-286607-5i406twr 132 26 Lactobacilli Lactobacilli NNP cord-286607-5i406twr 132 27 isolated isolate VBN cord-286607-5i406twr 132 28 from from IN cord-286607-5i406twr 132 29 KS KS NNP cord-286607-5i406twr 132 30 patients patient NNS cord-286607-5i406twr 132 31 ( ( -LRB- cord-286607-5i406twr 132 32 2/20 2/20 CD cord-286607-5i406twr 132 33 , , , cord-286607-5i406twr 132 34 10 10 CD cord-286607-5i406twr 132 35 % % NN cord-286607-5i406twr 132 36 ) ) -RRB- cord-286607-5i406twr 132 37 was be VBD cord-286607-5i406twr 132 38 significantly significantly RB cord-286607-5i406twr 132 39 lower low JJR cord-286607-5i406twr 132 40 ( ( -LRB- cord-286607-5i406twr 132 41 p p NN cord-286607-5i406twr 132 42 < < XX cord-286607-5i406twr 132 43 0.001 0.001 CD cord-286607-5i406twr 132 44 ) ) -RRB- cord-286607-5i406twr 132 45 than than IN cord-286607-5i406twr 132 46 in in IN cord-286607-5i406twr 132 47 the the DT cord-286607-5i406twr 132 48 other other JJ cord-286607-5i406twr 132 49 cohorts cohort NNS cord-286607-5i406twr 132 50 . . . cord-286607-5i406twr 133 1 Moreover moreover RB cord-286607-5i406twr 133 2 , , , cord-286607-5i406twr 133 3 no no DT cord-286607-5i406twr 133 4 significant significant JJ cord-286607-5i406twr 133 5 differences difference NNS cord-286607-5i406twr 133 6 in in IN cord-286607-5i406twr 133 7 the the DT cord-286607-5i406twr 133 8 presence presence NN cord-286607-5i406twr 133 9 of of IN cord-286607-5i406twr 133 10 Staphylococcus Staphylococcus NNP cord-286607-5i406twr 133 11 , , , cord-286607-5i406twr 133 12 Streptococcus Streptococcus NNP cord-286607-5i406twr 133 13 , , , cord-286607-5i406twr 133 14 Enterococcus Enterococcus NNP cord-286607-5i406twr 133 15 , , , cord-286607-5i406twr 133 16 Enterobacteriaceae Enterobacteriaceae NNP cord-286607-5i406twr 133 17 , , , cord-286607-5i406twr 133 18 Bifidobacterium bifidobacterium NN cord-286607-5i406twr 133 19 , , , cord-286607-5i406twr 133 20 Clostridium Clostridium NNP cord-286607-5i406twr 133 21 , , , cord-286607-5i406twr 133 22 Veillonella Veillonella NNP cord-286607-5i406twr 133 23 , , , cord-286607-5i406twr 133 24 or or CC cord-286607-5i406twr 133 25 Bacteroides Bacteroides NNP cord-286607-5i406twr 133 26 were be VBD cord-286607-5i406twr 133 27 found find VBN cord-286607-5i406twr 133 28 among among IN cord-286607-5i406twr 133 29 the the DT cord-286607-5i406twr 133 30 three three CD cord-286607-5i406twr 133 31 groups group NNS cord-286607-5i406twr 133 32 . . . cord-286607-5i406twr 134 1 Conversely conversely RB cord-286607-5i406twr 134 2 , , , cord-286607-5i406twr 134 3 the the DT cord-286607-5i406twr 134 4 presence presence NN cord-286607-5i406twr 134 5 of of IN cord-286607-5i406twr 134 6 Eubacterium Eubacterium NNP cord-286607-5i406twr 134 7 and and CC cord-286607-5i406twr 134 8 Peptostreptococcus Peptostreptococcus NNP cord-286607-5i406twr 134 9 was be VBD cord-286607-5i406twr 134 10 significantly significantly RB cord-286607-5i406twr 134 11 higher high JJR cord-286607-5i406twr 134 12 in in IN cord-286607-5i406twr 134 13 KS KS NNP cord-286607-5i406twr 134 14 patients patient NNS cord-286607-5i406twr 134 15 than than IN cord-286607-5i406twr 134 16 in in IN cord-286607-5i406twr 134 17 patients patient NNS cord-286607-5i406twr 134 18 with with IN cord-286607-5i406twr 134 19 other other JJ cord-286607-5i406twr 134 20 febrile febrile JJ cord-286607-5i406twr 134 21 diseases disease NNS cord-286607-5i406twr 134 22 ( ( -LRB- cord-286607-5i406twr 134 23 p p NN cord-286607-5i406twr 134 24 < < XX cord-286607-5i406twr 134 25 0.01 0.01 CD cord-286607-5i406twr 134 26 and and CC cord-286607-5i406twr 134 27 p p NN cord-286607-5i406twr 134 28 < < XX cord-286607-5i406twr 134 29 0.05 0.05 CD cord-286607-5i406twr 134 30 , , , cord-286607-5i406twr 134 31 respectively respectively RB cord-286607-5i406twr 134 32 ) ) -RRB- cord-286607-5i406twr 134 33 , , , cord-286607-5i406twr 134 34 though though IN cord-286607-5i406twr 134 35 no no DT cord-286607-5i406twr 134 36 significant significant JJ cord-286607-5i406twr 134 37 differences difference NNS cord-286607-5i406twr 134 38 were be VBD cord-286607-5i406twr 134 39 observed observe VBN cord-286607-5i406twr 134 40 between between IN cord-286607-5i406twr 134 41 KS KS NNP cord-286607-5i406twr 134 42 patients patient NNS cord-286607-5i406twr 134 43 and and CC cord-286607-5i406twr 134 44 healthy healthy JJ cord-286607-5i406twr 134 45 children child NNS cord-286607-5i406twr 134 46 ( ( -LRB- cord-286607-5i406twr 134 47 89 89 CD cord-286607-5i406twr 134 48 ) ) -RRB- cord-286607-5i406twr 134 49 . . . cord-286607-5i406twr 135 1 This this DT cord-286607-5i406twr 135 2 observation observation NN cord-286607-5i406twr 135 3 confirmed confirm VBD cord-286607-5i406twr 135 4 that that IN cord-286607-5i406twr 135 5 the the DT cord-286607-5i406twr 135 6 majority majority NN cord-286607-5i406twr 135 7 of of IN cord-286607-5i406twr 135 8 Lactobacillus lactobacillus NN cord-286607-5i406twr 135 9 species specie NNS cord-286607-5i406twr 135 10 are be VBP cord-286607-5i406twr 135 11 anti anti JJ cord-286607-5i406twr 135 12 - - JJ cord-286607-5i406twr 135 13 inflammatory inflammatory JJ cord-286607-5i406twr 135 14 and and CC cord-286607-5i406twr 135 15 beneficial beneficial JJ cord-286607-5i406twr 135 16 for for IN cord-286607-5i406twr 135 17 health health NN cord-286607-5i406twr 135 18 , , , cord-286607-5i406twr 135 19 particularly particularly RB cord-286607-5i406twr 135 20 during during IN cord-286607-5i406twr 135 21 the the DT cord-286607-5i406twr 135 22 first first JJ cord-286607-5i406twr 135 23 years year NNS cord-286607-5i406twr 135 24 of of IN cord-286607-5i406twr 135 25 life life NN cord-286607-5i406twr 135 26 , , , cord-286607-5i406twr 135 27 due due IN cord-286607-5i406twr 135 28 to to IN cord-286607-5i406twr 135 29 their -PRON- PRP$ cord-286607-5i406twr 135 30 action action NN cord-286607-5i406twr 135 31 in in IN cord-286607-5i406twr 135 32 protecting protect VBG cord-286607-5i406twr 135 33 against against IN cord-286607-5i406twr 135 34 colitis colitis NN cord-286607-5i406twr 135 35 , , , cord-286607-5i406twr 135 36 reducing reduce VBG cord-286607-5i406twr 135 37 pro pro JJ cord-286607-5i406twr 135 38 - - JJ cord-286607-5i406twr 135 39 inflammatory inflammatory JJ cord-286607-5i406twr 135 40 cytokines cytokine NNS cord-286607-5i406twr 135 41 such such JJ cord-286607-5i406twr 135 42 as as IN cord-286607-5i406twr 135 43 TNF TNF NNP cord-286607-5i406twr 135 44 - - HYPH cord-286607-5i406twr 135 45 α α NNP cord-286607-5i406twr 135 46 , , , cord-286607-5i406twr 135 47 IL-1 IL-1 NNP cord-286607-5i406twr 135 48 , , , cord-286607-5i406twr 135 49 or or CC cord-286607-5i406twr 135 50 IL-6 IL-6 NNP cord-286607-5i406twr 135 51 , , , cord-286607-5i406twr 135 52 and and CC cord-286607-5i406twr 135 53 increasing increase VBG cord-286607-5i406twr 135 54 the the DT cord-286607-5i406twr 135 55 subsets subset NNS cord-286607-5i406twr 135 56 of of IN cord-286607-5i406twr 135 57 regulatory regulatory JJ cord-286607-5i406twr 135 58 T t NN cord-286607-5i406twr 135 59 cells cell NNS cord-286607-5i406twr 135 60 ( ( -LRB- cord-286607-5i406twr 135 61 90 90 CD cord-286607-5i406twr 135 62 ) ) -RRB- cord-286607-5i406twr 135 63 . . . cord-286607-5i406twr 136 1 In in IN cord-286607-5i406twr 136 2 fact fact NN cord-286607-5i406twr 136 3 , , , cord-286607-5i406twr 136 4 several several JJ cord-286607-5i406twr 136 5 studies study NNS cord-286607-5i406twr 136 6 have have VBP cord-286607-5i406twr 136 7 largely largely RB cord-286607-5i406twr 136 8 described describe VBN cord-286607-5i406twr 136 9 the the DT cord-286607-5i406twr 136 10 specific specific JJ cord-286607-5i406twr 136 11 action action NN cord-286607-5i406twr 136 12 of of IN cord-286607-5i406twr 136 13 Lactobacilli Lactobacilli NNP cord-286607-5i406twr 136 14 in in IN cord-286607-5i406twr 136 15 maintaining maintain VBG cord-286607-5i406twr 136 16 the the DT cord-286607-5i406twr 136 17 epithelial epithelial JJ cord-286607-5i406twr 136 18 homeostasis homeostasis NN cord-286607-5i406twr 136 19 of of IN cord-286607-5i406twr 136 20 the the DT cord-286607-5i406twr 136 21 gut gut NN cord-286607-5i406twr 136 22 and and CC cord-286607-5i406twr 136 23 their -PRON- PRP$ cord-286607-5i406twr 136 24 striking striking JJ cord-286607-5i406twr 136 25 anti anti JJ cord-286607-5i406twr 136 26 - - JJ cord-286607-5i406twr 136 27 inflammatory inflammatory JJ cord-286607-5i406twr 136 28 potential potential NN cord-286607-5i406twr 136 29 ( ( -LRB- cord-286607-5i406twr 136 30 91 91 CD cord-286607-5i406twr 136 31 , , , cord-286607-5i406twr 136 32 92 92 CD cord-286607-5i406twr 136 33 ) ) -RRB- cord-286607-5i406twr 136 34 . . . cord-286607-5i406twr 137 1 Nagata Nagata NNP cord-286607-5i406twr 137 2 et et NNP cord-286607-5i406twr 137 3 al al NNP cord-286607-5i406twr 137 4 . . . cord-286607-5i406twr 138 1 ( ( -LRB- cord-286607-5i406twr 138 2 93 93 CD cord-286607-5i406twr 138 3 ) ) -RRB- cord-286607-5i406twr 138 4 also also RB cord-286607-5i406twr 138 5 studied study VBD cord-286607-5i406twr 138 6 the the DT cord-286607-5i406twr 138 7 role role NN cord-286607-5i406twr 138 8 of of IN cord-286607-5i406twr 138 9 the the DT cord-286607-5i406twr 138 10 gut gut NN cord-286607-5i406twr 138 11 microbiota microbiota NN cord-286607-5i406twr 138 12 in in IN cord-286607-5i406twr 138 13 KS KS NNP cord-286607-5i406twr 138 14 pathogenesis pathogenesis NN cord-286607-5i406twr 138 15 via via IN cord-286607-5i406twr 138 16 SAgs SAgs NNP cord-286607-5i406twr 138 17 and and CC cord-286607-5i406twr 138 18 heat heat NN cord-286607-5i406twr 138 19 shock shock NN cord-286607-5i406twr 138 20 proteins protein NNS cord-286607-5i406twr 139 1 ( ( -LRB- cord-286607-5i406twr 139 2 Hsps Hsps NNP cord-286607-5i406twr 139 3 ) ) -RRB- cord-286607-5i406twr 139 4 produced produce VBN cord-286607-5i406twr 139 5 by by IN cord-286607-5i406twr 139 6 gut gut NN cord-286607-5i406twr 139 7 bacteria bacteria NNS cord-286607-5i406twr 139 8 : : : cord-286607-5i406twr 140 1 the the DT cord-286607-5i406twr 140 2 authors author NNS cord-286607-5i406twr 140 3 evaluated evaluate VBD cord-286607-5i406twr 140 4 Sags Sags NNP cord-286607-5i406twr 140 5 and and CC cord-286607-5i406twr 140 6 Hsps Hsps NNP cord-286607-5i406twr 140 7 released release VBN cord-286607-5i406twr 140 8 by by IN cord-286607-5i406twr 140 9 microorganisms microorganism NNS cord-286607-5i406twr 140 10 isolated isolate VBN cord-286607-5i406twr 140 11 from from IN cord-286607-5i406twr 140 12 the the DT cord-286607-5i406twr 140 13 jejunal jejunal JJ cord-286607-5i406twr 140 14 mucosa mucosa NN cord-286607-5i406twr 140 15 of of IN cord-286607-5i406twr 140 16 19 19 CD cord-286607-5i406twr 140 17 children child NNS cord-286607-5i406twr 140 18 with with IN cord-286607-5i406twr 140 19 KS KS NNP cord-286607-5i406twr 140 20 compared compare VBN cord-286607-5i406twr 140 21 with with IN cord-286607-5i406twr 140 22 15 15 CD cord-286607-5i406twr 140 23 age age NN cord-286607-5i406twr 140 24 - - HYPH cord-286607-5i406twr 140 25 matched match VBN cord-286607-5i406twr 140 26 healthy healthy JJ cord-286607-5i406twr 140 27 controls control NNS cord-286607-5i406twr 140 28 , , , cord-286607-5i406twr 140 29 identifying identify VBG cord-286607-5i406twr 140 30 13 13 CD cord-286607-5i406twr 140 31 strains strain NNS cord-286607-5i406twr 140 32 of of IN cord-286607-5i406twr 140 33 Gram gram NN cord-286607-5i406twr 140 34 - - HYPH cord-286607-5i406twr 140 35 negative negative JJ cord-286607-5i406twr 140 36 microbes microbe NNS cord-286607-5i406twr 140 37 from from IN cord-286607-5i406twr 140 38 patients patient NNS cord-286607-5i406twr 140 39 with with IN cord-286607-5i406twr 140 40 KS KS NNP cord-286607-5i406twr 140 41 , , , cord-286607-5i406twr 140 42 which which WDT cord-286607-5i406twr 140 43 produced produce VBD cord-286607-5i406twr 140 44 a a DT cord-286607-5i406twr 140 45 large large JJ cord-286607-5i406twr 140 46 amount amount NN cord-286607-5i406twr 140 47 of of IN cord-286607-5i406twr 140 48 Hsp60 Hsp60 NNP cord-286607-5i406twr 140 49 , , , cord-286607-5i406twr 140 50 having have VBG cord-286607-5i406twr 140 51 the the DT cord-286607-5i406twr 140 52 power power NN cord-286607-5i406twr 140 53 to to TO cord-286607-5i406twr 140 54 induce induce VB cord-286607-5i406twr 140 55 an an DT cord-286607-5i406twr 140 56 over over IN cord-286607-5i406twr 140 57 - - HYPH cord-286607-5i406twr 140 58 secretion secretion NN cord-286607-5i406twr 140 59 of of IN cord-286607-5i406twr 140 60 proinflammatory proinflammatory JJ cord-286607-5i406twr 140 61 cytokines cytokine NNS cord-286607-5i406twr 140 62 . . . cord-286607-5i406twr 141 1 They -PRON- PRP cord-286607-5i406twr 141 2 also also RB cord-286607-5i406twr 141 3 identified identify VBD cord-286607-5i406twr 141 4 18 18 CD cord-286607-5i406twr 141 5 strains strain NNS cord-286607-5i406twr 141 6 of of IN cord-286607-5i406twr 141 7 Grampositive Grampositive NNP cord-286607-5i406twr 141 8 cocci coccus NNS cord-286607-5i406twr 141 9 with with IN cord-286607-5i406twr 141 10 SAg SAg NNS cord-286607-5i406twr 141 11 properties property NNS cord-286607-5i406twr 141 12 which which WDT cord-286607-5i406twr 141 13 induced induce VBD cord-286607-5i406twr 141 14 the the DT cord-286607-5i406twr 141 15 expansion expansion NN cord-286607-5i406twr 141 16 of of IN cord-286607-5i406twr 141 17 Vβ2 Vβ2 NNP cord-286607-5i406twr 141 18 T T NNP cord-286607-5i406twr 141 19 cells cell NNS cord-286607-5i406twr 141 20 in in IN cord-286607-5i406twr 141 21 vitro vitro FW cord-286607-5i406twr 141 22 ( ( -LRB- cord-286607-5i406twr 141 23 93 93 CD cord-286607-5i406twr 141 24 ) ) -RRB- cord-286607-5i406twr 141 25 . . . cord-286607-5i406twr 142 1 This this DT cord-286607-5i406twr 142 2 microbiological microbiological JJ cord-286607-5i406twr 142 3 analysis analysis NN cord-286607-5i406twr 142 4 disclosed disclose VBD cord-286607-5i406twr 142 5 different different JJ cord-286607-5i406twr 142 6 causative causative JJ cord-286607-5i406twr 142 7 bacteria bacteria NNS cord-286607-5i406twr 142 8 with with IN cord-286607-5i406twr 142 9 a a DT cord-286607-5i406twr 142 10 final final JJ cord-286607-5i406twr 142 11 common common JJ cord-286607-5i406twr 142 12 pathway pathway NN cord-286607-5i406twr 142 13 of of IN cord-286607-5i406twr 142 14 immune immune JJ cord-286607-5i406twr 142 15 activation activation NN cord-286607-5i406twr 142 16 , , , cord-286607-5i406twr 142 17 which which WDT cord-286607-5i406twr 142 18 might may MD cord-286607-5i406twr 142 19 contribute contribute VB cord-286607-5i406twr 142 20 to to IN cord-286607-5i406twr 142 21 the the DT cord-286607-5i406twr 142 22 final final JJ cord-286607-5i406twr 142 23 development development NN cord-286607-5i406twr 142 24 of of IN cord-286607-5i406twr 142 25 KS KS NNP cord-286607-5i406twr 142 26 . . . cord-286607-5i406twr 143 1 In in IN cord-286607-5i406twr 143 2 order order NN cord-286607-5i406twr 143 3 to to TO cord-286607-5i406twr 143 4 evaluate evaluate VB cord-286607-5i406twr 143 5 the the DT cord-286607-5i406twr 143 6 differential differential JJ cord-286607-5i406twr 143 7 microbiota microbiota NN cord-286607-5i406twr 143 8 composition composition NN cord-286607-5i406twr 143 9 of of IN cord-286607-5i406twr 143 10 KS KS NNP cord-286607-5i406twr 143 11 patients patient NNS cord-286607-5i406twr 143 12 , , , cord-286607-5i406twr 143 13 Kinumaki Kinumaki NNP cord-286607-5i406twr 143 14 et et NNP cord-286607-5i406twr 143 15 al al NNP cord-286607-5i406twr 143 16 . . . cord-286607-5i406twr 144 1 ( ( -LRB- cord-286607-5i406twr 144 2 94 94 CD cord-286607-5i406twr 144 3 ) ) -RRB- cord-286607-5i406twr 144 4 performed perform VBD cord-286607-5i406twr 144 5 a a DT cord-286607-5i406twr 144 6 metagenomic metagenomic NN cord-286607-5i406twr 144 7 analysis analysis NN cord-286607-5i406twr 144 8 using use VBG cord-286607-5i406twr 144 9 non non JJ cord-286607-5i406twr 144 10 - - JJ cord-286607-5i406twr 144 11 culture culture NN cord-286607-5i406twr 144 12 - - HYPH cord-286607-5i406twr 144 13 based base VBN cord-286607-5i406twr 144 14 methods method NNS cord-286607-5i406twr 144 15 on on IN cord-286607-5i406twr 144 16 feces fece NNS cord-286607-5i406twr 144 17 . . . cord-286607-5i406twr 145 1 Their -PRON- PRP$ cord-286607-5i406twr 145 2 study study NN cord-286607-5i406twr 145 3 included include VBD cord-286607-5i406twr 145 4 28 28 CD cord-286607-5i406twr 145 5 KS KS NNP cord-286607-5i406twr 145 6 patients patient NNS cord-286607-5i406twr 145 7 ( ( -LRB- cord-286607-5i406twr 145 8 15 15 CD cord-286607-5i406twr 145 9 males male NNS cord-286607-5i406twr 145 10 and and CC cord-286607-5i406twr 145 11 13 13 CD cord-286607-5i406twr 145 12 females female NNS cord-286607-5i406twr 145 13 , , , cord-286607-5i406twr 145 14 aged aged JJ cord-286607-5i406twr 145 15 1 1 CD cord-286607-5i406twr 145 16 - - SYM cord-286607-5i406twr 145 17 114 114 CD cord-286607-5i406twr 145 18 months month NNS cord-286607-5i406twr 145 19 , , , cord-286607-5i406twr 145 20 with with IN cord-286607-5i406twr 145 21 a a DT cord-286607-5i406twr 145 22 median median JJ cord-286607-5i406twr 145 23 age age NN cord-286607-5i406twr 145 24 of of IN cord-286607-5i406twr 145 25 25 25 CD cord-286607-5i406twr 145 26 months month NNS cord-286607-5i406twr 145 27 ) ) -RRB- cord-286607-5i406twr 145 28 ; ; : cord-286607-5i406twr 145 29 the the DT cord-286607-5i406twr 145 30 time time NN cord-286607-5i406twr 145 31 of of IN cord-286607-5i406twr 145 32 admission admission NN cord-286607-5i406twr 145 33 to to IN cord-286607-5i406twr 145 34 the the DT cord-286607-5i406twr 145 35 study study NN cord-286607-5i406twr 145 36 was be VBD cord-286607-5i406twr 145 37 defined define VBN cord-286607-5i406twr 145 38 as as IN cord-286607-5i406twr 145 39 the the DT cord-286607-5i406twr 145 40 acute acute JJ cord-286607-5i406twr 145 41 phase phase NN cord-286607-5i406twr 145 42 , , , cord-286607-5i406twr 145 43 while while IN cord-286607-5i406twr 145 44 4 4 CD cord-286607-5i406twr 145 45 - - SYM cord-286607-5i406twr 145 46 6 6 CD cord-286607-5i406twr 145 47 months month NNS cord-286607-5i406twr 145 48 after after IN cord-286607-5i406twr 145 49 the the DT cord-286607-5i406twr 145 50 onset onset NN cord-286607-5i406twr 145 51 of of IN cord-286607-5i406twr 145 52 KS KS NNP cord-286607-5i406twr 145 53 was be VBD cord-286607-5i406twr 145 54 considered consider VBN cord-286607-5i406twr 145 55 as as IN cord-286607-5i406twr 145 56 the the DT cord-286607-5i406twr 145 57 nonacute nonacute NNP cord-286607-5i406twr 145 58 phase phase NN cord-286607-5i406twr 145 59 . . . cord-286607-5i406twr 146 1 The the DT cord-286607-5i406twr 146 2 authors author NNS cord-286607-5i406twr 146 3 collected collect VBD cord-286607-5i406twr 146 4 a a DT cord-286607-5i406twr 146 5 total total NN cord-286607-5i406twr 146 6 of of IN cord-286607-5i406twr 146 7 56 56 CD cord-286607-5i406twr 146 8 samples−28 samples−28 JJ cord-286607-5i406twr 146 9 samples sample NNS cord-286607-5i406twr 146 10 each each DT cord-286607-5i406twr 146 11 for for IN cord-286607-5i406twr 146 12 both both CC cord-286607-5i406twr 146 13 acute acute JJ cord-286607-5i406twr 146 14 and and CC cord-286607-5i406twr 146 15 non non JJ cord-286607-5i406twr 146 16 - - JJ cord-286607-5i406twr 146 17 acute acute JJ cord-286607-5i406twr 146 18 phases phase NNS cord-286607-5i406twr 146 19 . . . cord-286607-5i406twr 147 1 It -PRON- PRP cord-286607-5i406twr 147 2 was be VBD cord-286607-5i406twr 147 3 demonstrated demonstrate VBN cord-286607-5i406twr 147 4 that that IN cord-286607-5i406twr 147 5 the the DT cord-286607-5i406twr 147 6 genera genera NNP cord-286607-5i406twr 147 7 Ruminococcus Ruminococcus NNP cord-286607-5i406twr 147 8 , , , cord-286607-5i406twr 147 9 Roseburia Roseburia NNP cord-286607-5i406twr 147 10 , , , cord-286607-5i406twr 147 11 and and CC cord-286607-5i406twr 147 12 Faecalibacterium Faecalibacterium NNP cord-286607-5i406twr 147 13 were be VBD cord-286607-5i406twr 147 14 mostly mostly RB cord-286607-5i406twr 147 15 predominant predominant JJ cord-286607-5i406twr 147 16 during during IN cord-286607-5i406twr 147 17 the the DT cord-286607-5i406twr 147 18 nonacute nonacute NNP cord-286607-5i406twr 147 19 phase phase NN cord-286607-5i406twr 147 20 , , , cord-286607-5i406twr 147 21 while while IN cord-286607-5i406twr 147 22 a a DT cord-286607-5i406twr 147 23 higher high JJR cord-286607-5i406twr 147 24 presence presence NN cord-286607-5i406twr 147 25 of of IN cord-286607-5i406twr 147 26 Streptococcus Streptococcus NNP cord-286607-5i406twr 147 27 spp spp NNS cord-286607-5i406twr 147 28 . . . cord-286607-5i406twr 148 1 , , , cord-286607-5i406twr 148 2 including include VBG cord-286607-5i406twr 148 3 Streptococcus streptococcus NN cord-286607-5i406twr 148 4 pneumoniae pneumoniae NN cord-286607-5i406twr 148 5 , , , cord-286607-5i406twr 148 6 pseudopneumoniae pseudopneumoniae NNP cord-286607-5i406twr 148 7 , , , cord-286607-5i406twr 148 8 mitis mitis NNP cord-286607-5i406twr 148 9 , , , cord-286607-5i406twr 148 10 oralis oralis NNP cord-286607-5i406twr 148 11 , , , cord-286607-5i406twr 148 12 gordonii gordonii NNP cord-286607-5i406twr 148 13 , , , cord-286607-5i406twr 148 14 and and CC cord-286607-5i406twr 148 15 sanguinis sanguinis NNP cord-286607-5i406twr 148 16 , , , cord-286607-5i406twr 148 17 was be VBD cord-286607-5i406twr 148 18 detected detect VBN cord-286607-5i406twr 148 19 in in IN cord-286607-5i406twr 148 20 the the DT cord-286607-5i406twr 148 21 fecal fecal JJ cord-286607-5i406twr 148 22 samples sample NNS cord-286607-5i406twr 148 23 during during IN cord-286607-5i406twr 148 24 the the DT cord-286607-5i406twr 148 25 acute acute JJ cord-286607-5i406twr 148 26 phase phase NN cord-286607-5i406twr 148 27 ( ( -LRB- cord-286607-5i406twr 148 28 94 94 CD cord-286607-5i406twr 148 29 ) ) -RRB- cord-286607-5i406twr 148 30 . . . cord-286607-5i406twr 149 1 This this DT cord-286607-5i406twr 149 2 novel novel JJ cord-286607-5i406twr 149 3 interpretation interpretation NN cord-286607-5i406twr 149 4 of of IN cord-286607-5i406twr 149 5 a a DT cord-286607-5i406twr 149 6 disease disease NN cord-286607-5i406twr 149 7 can can MD cord-286607-5i406twr 149 8 be be VB cord-286607-5i406twr 149 9 shared share VBN cord-286607-5i406twr 149 10 by by IN cord-286607-5i406twr 149 11 other other JJ cord-286607-5i406twr 149 12 conditions condition NNS cord-286607-5i406twr 149 13 , , , cord-286607-5i406twr 149 14 as as IN cord-286607-5i406twr 149 15 liver liver NN cord-286607-5i406twr 149 16 cirrhosis cirrhosis NN cord-286607-5i406twr 149 17 and and CC cord-286607-5i406twr 149 18 Sjögren Sjögren NNP cord-286607-5i406twr 149 19 syndrome syndrome NN cord-286607-5i406twr 149 20 , , , cord-286607-5i406twr 149 21 in in IN cord-286607-5i406twr 149 22 which which WDT cord-286607-5i406twr 149 23 major major JJ cord-286607-5i406twr 149 24 changes change NNS cord-286607-5i406twr 149 25 of of IN cord-286607-5i406twr 149 26 gut gut NN cord-286607-5i406twr 149 27 microbiota microbiota NN cord-286607-5i406twr 149 28 with with IN cord-286607-5i406twr 149 29 higher high JJR cord-286607-5i406twr 149 30 proportions proportion NNS cord-286607-5i406twr 149 31 of of IN cord-286607-5i406twr 149 32 Streptococcus streptococcus NN cord-286607-5i406twr 149 33 spp spp NNS cord-286607-5i406twr 149 34 . . . cord-286607-5i406twr 150 1 have have VBP cord-286607-5i406twr 150 2 been be VBN cord-286607-5i406twr 150 3 demonstrated demonstrate VBN cord-286607-5i406twr 150 4 ( ( -LRB- cord-286607-5i406twr 150 5 95 95 CD cord-286607-5i406twr 150 6 , , , cord-286607-5i406twr 150 7 96 96 CD cord-286607-5i406twr 150 8 ) ) -RRB- cord-286607-5i406twr 150 9 . . . cord-286607-5i406twr 151 1 These these DT cord-286607-5i406twr 151 2 findings finding NNS cord-286607-5i406twr 151 3 taken take VBN cord-286607-5i406twr 151 4 as as IN cord-286607-5i406twr 151 5 a a DT cord-286607-5i406twr 151 6 whole whole NN cord-286607-5i406twr 151 7 suggest suggest VBP cord-286607-5i406twr 151 8 that that IN cord-286607-5i406twr 151 9 many many JJ cord-286607-5i406twr 151 10 other other JJ cord-286607-5i406twr 151 11 immune immune NN cord-286607-5i406twr 151 12 - - HYPH cord-286607-5i406twr 151 13 mediated mediate VBN cord-286607-5i406twr 151 14 disorders disorder NNS cord-286607-5i406twr 151 15 are be VBP cord-286607-5i406twr 151 16 likely likely JJ cord-286607-5i406twr 151 17 to to TO cord-286607-5i406twr 151 18 be be VB cord-286607-5i406twr 151 19 connected connect VBN cord-286607-5i406twr 151 20 to to IN cord-286607-5i406twr 151 21 an an DT cord-286607-5i406twr 151 22 abnormal abnormal JJ cord-286607-5i406twr 151 23 bacterial bacterial JJ cord-286607-5i406twr 151 24 colonization colonization NN cord-286607-5i406twr 151 25 of of IN cord-286607-5i406twr 151 26 the the DT cord-286607-5i406twr 151 27 intestinal intestinal JJ cord-286607-5i406twr 151 28 tract tract NN cord-286607-5i406twr 151 29 , , , cord-286607-5i406twr 151 30 with with IN cord-286607-5i406twr 151 31 a a DT cord-286607-5i406twr 151 32 main main JJ cord-286607-5i406twr 151 33 role role NN cord-286607-5i406twr 151 34 for for IN cord-286607-5i406twr 151 35 Streptococcus Streptococcus NNP cord-286607-5i406twr 151 36 spp spp NNS cord-286607-5i406twr 151 37 . . . cord-286607-5i406twr 152 1 , , , cord-286607-5i406twr 152 2 and and CC cord-286607-5i406twr 152 3 that that IN cord-286607-5i406twr 152 4 changes change NNS cord-286607-5i406twr 152 5 in in IN cord-286607-5i406twr 152 6 the the DT cord-286607-5i406twr 152 7 gut gut NN cord-286607-5i406twr 152 8 microflora microflora NN cord-286607-5i406twr 152 9 composition composition NN cord-286607-5i406twr 152 10 might may MD cord-286607-5i406twr 152 11 promote promote VB cord-286607-5i406twr 152 12 systemic systemic JJ cord-286607-5i406twr 152 13 and and CC cord-286607-5i406twr 152 14 extra extra JJ cord-286607-5i406twr 152 15 - - JJ cord-286607-5i406twr 152 16 intestinal intestinal JJ cord-286607-5i406twr 152 17 inflammation inflammation NN cord-286607-5i406twr 152 18 . . . cord-286607-5i406twr 153 1 Therefore therefore RB cord-286607-5i406twr 153 2 , , , cord-286607-5i406twr 153 3 all all DT cord-286607-5i406twr 153 4 presented present VBN cord-286607-5i406twr 153 5 studies study NNS cord-286607-5i406twr 153 6 confirm confirm VBP cord-286607-5i406twr 153 7 the the DT cord-286607-5i406twr 153 8 concept concept NN cord-286607-5i406twr 153 9 that that IN cord-286607-5i406twr 153 10 an an DT cord-286607-5i406twr 153 11 imbalance imbalance NN cord-286607-5i406twr 153 12 in in IN cord-286607-5i406twr 153 13 the the DT cord-286607-5i406twr 153 14 gut gut NN cord-286607-5i406twr 153 15 microbiota microbiota NN cord-286607-5i406twr 153 16 might may MD cord-286607-5i406twr 153 17 directly directly RB cord-286607-5i406twr 153 18 or or CC cord-286607-5i406twr 153 19 indirectly indirectly RB cord-286607-5i406twr 153 20 interfere interfere VB cord-286607-5i406twr 153 21 with with IN cord-286607-5i406twr 153 22 the the DT cord-286607-5i406twr 153 23 normal normal JJ cord-286607-5i406twr 153 24 functions function NNS cord-286607-5i406twr 153 25 of of IN cord-286607-5i406twr 153 26 the the DT cord-286607-5i406twr 153 27 immune immune JJ cord-286607-5i406twr 153 28 system system NN cord-286607-5i406twr 153 29 , , , cord-286607-5i406twr 153 30 and and CC cord-286607-5i406twr 153 31 that that IN cord-286607-5i406twr 153 32 the the DT cord-286607-5i406twr 153 33 interaction interaction NN cord-286607-5i406twr 153 34 with with IN cord-286607-5i406twr 153 35 other other JJ cord-286607-5i406twr 153 36 environmental environmental JJ cord-286607-5i406twr 153 37 factors factor NNS cord-286607-5i406twr 153 38 , , , cord-286607-5i406twr 153 39 mainly mainly RB cord-286607-5i406twr 153 40 infectious infectious JJ cord-286607-5i406twr 153 41 agents agent NNS cord-286607-5i406twr 153 42 , , , cord-286607-5i406twr 153 43 might may MD cord-286607-5i406twr 153 44 lead lead VB cord-286607-5i406twr 153 45 to to IN cord-286607-5i406twr 153 46 the the DT cord-286607-5i406twr 153 47 final final JJ cord-286607-5i406twr 153 48 development development NN cord-286607-5i406twr 153 49 of of IN cord-286607-5i406twr 153 50 KS KS NNP cord-286607-5i406twr 153 51 . . . cord-286607-5i406twr 154 1 Table table NN cord-286607-5i406twr 154 2 1 1 CD cord-286607-5i406twr 154 3 shows show VBZ cord-286607-5i406twr 154 4 the the DT cord-286607-5i406twr 154 5 characteristics characteristic NNS cord-286607-5i406twr 154 6 of of IN cord-286607-5i406twr 154 7 the the DT cord-286607-5i406twr 154 8 microbiota microbiota NN cord-286607-5i406twr 154 9 in in IN cord-286607-5i406twr 154 10 children child NNS cord-286607-5i406twr 154 11 with with IN cord-286607-5i406twr 154 12 KS KS NNP cord-286607-5i406twr 154 13 , , , cord-286607-5i406twr 154 14 as as IN cord-286607-5i406twr 154 15 emerging emerge VBG cord-286607-5i406twr 154 16 by by IN cord-286607-5i406twr 154 17 the the DT cord-286607-5i406twr 154 18 most most RBS cord-286607-5i406twr 154 19 relevant relevant JJ cord-286607-5i406twr 154 20 studies study NNS cord-286607-5i406twr 154 21 dedicated dedicate VBN cord-286607-5i406twr 154 22 to to IN cord-286607-5i406twr 154 23 this this DT cord-286607-5i406twr 154 24 issue issue NN cord-286607-5i406twr 154 25 . . . cord-286607-5i406twr 155 1 As as IN cord-286607-5i406twr 155 2 no no DT cord-286607-5i406twr 155 3 etiologic etiologic JJ cord-286607-5i406twr 155 4 agent agent NN cord-286607-5i406twr 155 5 has have VBZ cord-286607-5i406twr 155 6 ever ever RB cord-286607-5i406twr 155 7 been be VBN cord-286607-5i406twr 155 8 accused accuse VBN cord-286607-5i406twr 155 9 of of IN cord-286607-5i406twr 155 10 being be VBG cord-286607-5i406twr 155 11 directly directly RB cord-286607-5i406twr 155 12 involved involve VBN cord-286607-5i406twr 155 13 in in IN cord-286607-5i406twr 155 14 the the DT cord-286607-5i406twr 155 15 etiology etiology NN cord-286607-5i406twr 155 16 of of IN cord-286607-5i406twr 155 17 KS KS NNP cord-286607-5i406twr 155 18 , , , cord-286607-5i406twr 155 19 basic basic JJ cord-286607-5i406twr 155 20 research research NN cord-286607-5i406twr 155 21 evaluating evaluate VBG cord-286607-5i406twr 155 22 the the DT cord-286607-5i406twr 155 23 pathogenic pathogenic JJ cord-286607-5i406twr 155 24 mechanisms mechanism NNS cord-286607-5i406twr 155 25 of of IN cord-286607-5i406twr 155 26 this this DT cord-286607-5i406twr 155 27 disease disease NN cord-286607-5i406twr 155 28 will will MD cord-286607-5i406twr 155 29 probably probably RB cord-286607-5i406twr 155 30 provide provide VB cord-286607-5i406twr 155 31 better well JJR cord-286607-5i406twr 155 32 therapies therapy NNS cord-286607-5i406twr 155 33 and and CC cord-286607-5i406twr 155 34 probably probably RB cord-286607-5i406twr 155 35 consent consent VBP cord-286607-5i406twr 155 36 to to TO cord-286607-5i406twr 155 37 identify identify VB cord-286607-5i406twr 155 38 the the DT cord-286607-5i406twr 155 39 most most RBS cord-286607-5i406twr 155 40 vulnerable vulnerable JJ cord-286607-5i406twr 155 41 hosts host NNS cord-286607-5i406twr 155 42 and and CC cord-286607-5i406twr 155 43 protect protect VB cord-286607-5i406twr 155 44 them -PRON- PRP cord-286607-5i406twr 155 45 . . . cord-286607-5i406twr 156 1 A a DT cord-286607-5i406twr 156 2 potential potential JJ cord-286607-5i406twr 156 3 relationship relationship NN cord-286607-5i406twr 156 4 between between IN cord-286607-5i406twr 156 5 eubiosis eubiosis NN cord-286607-5i406twr 156 6 and and CC cord-286607-5i406twr 156 7 the the DT cord-286607-5i406twr 156 8 protean protean JJ cord-286607-5i406twr 156 9 functions function NNS cord-286607-5i406twr 156 10 of of IN cord-286607-5i406twr 156 11 immunity immunity NN cord-286607-5i406twr 156 12 has have VBZ cord-286607-5i406twr 156 13 been be VBN cord-286607-5i406twr 156 14 contemplated contemplate VBN cord-286607-5i406twr 156 15 by by IN cord-286607-5i406twr 156 16 different different JJ cord-286607-5i406twr 156 17 studies study NNS cord-286607-5i406twr 156 18 , , , cord-286607-5i406twr 156 19 and and CC cord-286607-5i406twr 156 20 conversely conversely RB cord-286607-5i406twr 156 21 a a DT cord-286607-5i406twr 156 22 relationship relationship NN cord-286607-5i406twr 156 23 should should MD cord-286607-5i406twr 156 24 exist exist VB cord-286607-5i406twr 156 25 between between IN cord-286607-5i406twr 156 26 dysbiosis dysbiosis NN cord-286607-5i406twr 156 27 and and CC cord-286607-5i406twr 156 28 immunity immunity NN cord-286607-5i406twr 156 29 dysfunction dysfunction NN cord-286607-5i406twr 156 30 shown show VBN cord-286607-5i406twr 156 31 by by IN cord-286607-5i406twr 156 32 various various JJ cord-286607-5i406twr 156 33 diseases disease NNS cord-286607-5i406twr 156 34 ( ( -LRB- cord-286607-5i406twr 156 35 97 97 CD cord-286607-5i406twr 156 36 ) ) -RRB- cord-286607-5i406twr 156 37 . . . cord-286607-5i406twr 157 1 It -PRON- PRP cord-286607-5i406twr 157 2 is be VBZ cord-286607-5i406twr 157 3 strengthened strengthen VBN cord-286607-5i406twr 157 4 that that IN cord-286607-5i406twr 157 5 heterogeneity heterogeneity NN cord-286607-5i406twr 157 6 and and CC cord-286607-5i406twr 157 7 abnormalities abnormality NNS cord-286607-5i406twr 157 8 in in IN cord-286607-5i406twr 157 9 the the DT cord-286607-5i406twr 157 10 intestinal intestinal JJ cord-286607-5i406twr 157 11 microflora microflora NN cord-286607-5i406twr 157 12 composition composition NN cord-286607-5i406twr 157 13 may may MD cord-286607-5i406twr 157 14 trigger trigger VB cord-286607-5i406twr 157 15 or or CC cord-286607-5i406twr 157 16 contribute contribute VB cord-286607-5i406twr 157 17 to to IN cord-286607-5i406twr 157 18 the the DT cord-286607-5i406twr 157 19 development development NN cord-286607-5i406twr 157 20 of of IN cord-286607-5i406twr 157 21 specific specific JJ cord-286607-5i406twr 157 22 diseases disease NNS cord-286607-5i406twr 157 23 , , , cord-286607-5i406twr 157 24 and and CC cord-286607-5i406twr 157 25 an an DT cord-286607-5i406twr 157 26 increasing increase VBG cord-286607-5i406twr 157 27 amount amount NN cord-286607-5i406twr 157 28 of of IN cord-286607-5i406twr 157 29 research research NN cord-286607-5i406twr 157 30 and and CC cord-286607-5i406twr 157 31 microbiologic microbiologic JJ cord-286607-5i406twr 157 32 observations observation NNS cord-286607-5i406twr 157 33 have have VBP cord-286607-5i406twr 157 34 led lead VBN cord-286607-5i406twr 157 35 to to IN cord-286607-5i406twr 157 36 a a DT cord-286607-5i406twr 157 37 role role NN cord-286607-5i406twr 157 38 of of IN cord-286607-5i406twr 157 39 the the DT cord-286607-5i406twr 157 40 intestinal intestinal JJ cord-286607-5i406twr 157 41 microbiota microbiota NN cord-286607-5i406twr 157 42 for for IN cord-286607-5i406twr 157 43 KS KS NNP cord-286607-5i406twr 157 44 to to TO cord-286607-5i406twr 157 45 be be VB cord-286607-5i406twr 157 46 postulated postulate VBN cord-286607-5i406twr 157 47 . . . cord-286607-5i406twr 158 1 While while IN cord-286607-5i406twr 158 2 we -PRON- PRP cord-286607-5i406twr 158 3 are be VBP cord-286607-5i406twr 158 4 becoming become VBG cord-286607-5i406twr 158 5 convinced convinced JJ cord-286607-5i406twr 158 6 that that IN cord-286607-5i406twr 158 7 a a DT cord-286607-5i406twr 158 8 role role NN cord-286607-5i406twr 158 9 of of IN cord-286607-5i406twr 158 10 the the DT cord-286607-5i406twr 158 11 microbiota microbiota NN cord-286607-5i406twr 158 12 is be VBZ cord-286607-5i406twr 158 13 likely likely JJ cord-286607-5i406twr 158 14 , , , cord-286607-5i406twr 158 15 we -PRON- PRP cord-286607-5i406twr 158 16 do do VBP cord-286607-5i406twr 158 17 not not RB cord-286607-5i406twr 158 18 know know VB cord-286607-5i406twr 158 19 exactly exactly RB cord-286607-5i406twr 158 20 the the DT cord-286607-5i406twr 158 21 basic basic JJ cord-286607-5i406twr 158 22 mechanism mechanism NN cord-286607-5i406twr 158 23 of of IN cord-286607-5i406twr 158 24 how how WRB cord-286607-5i406twr 158 25 the the DT cord-286607-5i406twr 158 26 microbiota microbiota NN cord-286607-5i406twr 158 27 should should MD cord-286607-5i406twr 158 28 act act VB cord-286607-5i406twr 158 29 . . . cord-286607-5i406twr 159 1 The the DT cord-286607-5i406twr 159 2 principal principal JJ cord-286607-5i406twr 159 3 obstacle obstacle NN cord-286607-5i406twr 159 4 of of IN cord-286607-5i406twr 159 5 today today NN cord-286607-5i406twr 159 6 's 's POS cord-286607-5i406twr 159 7 medical medical JJ cord-286607-5i406twr 159 8 literature literature NN cord-286607-5i406twr 159 9 is be VBZ cord-286607-5i406twr 159 10 to to TO cord-286607-5i406twr 159 11 understand understand VB cord-286607-5i406twr 159 12 if if IN cord-286607-5i406twr 159 13 the the DT cord-286607-5i406twr 159 14 microbiota microbiota NN cord-286607-5i406twr 159 15 modification modification NN cord-286607-5i406twr 159 16 during during IN cord-286607-5i406twr 159 17 KS KS NNP cord-286607-5i406twr 159 18 can can MD cord-286607-5i406twr 159 19 cause cause VB cord-286607-5i406twr 159 20 the the DT cord-286607-5i406twr 159 21 disease disease NN cord-286607-5i406twr 159 22 or or CC cord-286607-5i406twr 159 23 if if IN cord-286607-5i406twr 159 24 it -PRON- PRP cord-286607-5i406twr 159 25 is be VBZ cord-286607-5i406twr 159 26 a a DT cord-286607-5i406twr 159 27 mark mark NN cord-286607-5i406twr 159 28 and and CC cord-286607-5i406twr 159 29 a a DT cord-286607-5i406twr 159 30 consequence consequence NN cord-286607-5i406twr 159 31 of of IN cord-286607-5i406twr 159 32 the the DT cord-286607-5i406twr 159 33 disease disease NN cord-286607-5i406twr 159 34 itself -PRON- PRP cord-286607-5i406twr 159 35 , , , cord-286607-5i406twr 159 36 and and CC cord-286607-5i406twr 159 37 if if IN cord-286607-5i406twr 159 38 modulating modulate VBG cord-286607-5i406twr 159 39 the the DT cord-286607-5i406twr 159 40 microbiota microbiota NN cord-286607-5i406twr 159 41 / / SYM cord-286607-5i406twr 159 42 microbiome microbiome NN cord-286607-5i406twr 159 43 might may MD cord-286607-5i406twr 159 44 represent represent VB cord-286607-5i406twr 159 45 a a DT cord-286607-5i406twr 159 46 future future JJ cord-286607-5i406twr 159 47 target target NN cord-286607-5i406twr 159 48 of of IN cord-286607-5i406twr 159 49 therapy therapy NN cord-286607-5i406twr 159 50 in in IN cord-286607-5i406twr 159 51 KS KS NNP cord-286607-5i406twr 159 52 . . . cord-286607-5i406twr 160 1 This this DT cord-286607-5i406twr 160 2 raises raise VBZ cord-286607-5i406twr 160 3 the the DT cord-286607-5i406twr 160 4 hypothesis hypothesis NN cord-286607-5i406twr 160 5 of of IN cord-286607-5i406twr 160 6 targeting target VBG cord-286607-5i406twr 160 7 intestinal intestinal JJ cord-286607-5i406twr 160 8 microflora microflora NN cord-286607-5i406twr 160 9 in in IN cord-286607-5i406twr 160 10 order order NN cord-286607-5i406twr 160 11 to to TO cord-286607-5i406twr 160 12 restore restore VB cord-286607-5i406twr 160 13 eubiosis eubiosis NN cord-286607-5i406twr 160 14 through through IN cord-286607-5i406twr 160 15 the the DT cord-286607-5i406twr 160 16 rational rational JJ cord-286607-5i406twr 160 17 use use NN cord-286607-5i406twr 160 18 of of IN cord-286607-5i406twr 160 19 antibiotics antibiotic NNS cord-286607-5i406twr 160 20 , , , cord-286607-5i406twr 160 21 xenobiotics xenobiotic NNS cord-286607-5i406twr 160 22 , , , cord-286607-5i406twr 160 23 probiotics probiotic NNS cord-286607-5i406twr 160 24 and and CC cord-286607-5i406twr 160 25 nutrients nutrient NNS cord-286607-5i406twr 160 26 . . . cord-286607-5i406twr 161 1 While while IN cord-286607-5i406twr 161 2 multicenter multicenter JJ cord-286607-5i406twr 161 3 trials trial NNS cord-286607-5i406twr 161 4 and and CC cord-286607-5i406twr 161 5 registries registry NNS cord-286607-5i406twr 161 6 may may MD cord-286607-5i406twr 161 7 allow allow VB cord-286607-5i406twr 161 8 us -PRON- PRP cord-286607-5i406twr 161 9 to to TO cord-286607-5i406twr 161 10 improve improve VB cord-286607-5i406twr 161 11 the the DT cord-286607-5i406twr 161 12 general general JJ cord-286607-5i406twr 161 13 outcome outcome NN cord-286607-5i406twr 161 14 of of IN cord-286607-5i406twr 161 15 KS KS NNP cord-286607-5i406twr 161 16 , , , cord-286607-5i406twr 161 17 further far RBR cord-286607-5i406twr 161 18 in in IN cord-286607-5i406twr 161 19 - - HYPH cord-286607-5i406twr 161 20 depth depth NN cord-286607-5i406twr 161 21 analysis analysis NN cord-286607-5i406twr 161 22 in in IN cord-286607-5i406twr 161 23 larger large JJR cord-286607-5i406twr 161 24 cohorts cohort NNS cord-286607-5i406twr 161 25 of of IN cord-286607-5i406twr 161 26 affected affected JJ cord-286607-5i406twr 161 27 children child NNS cord-286607-5i406twr 161 28 will will MD cord-286607-5i406twr 161 29 probably probably RB cord-286607-5i406twr 161 30 unravel unravel VB cord-286607-5i406twr 161 31 the the DT cord-286607-5i406twr 161 32 tangled tangled JJ cord-286607-5i406twr 161 33 pathogenesis pathogenesis NN cord-286607-5i406twr 161 34 of of IN cord-286607-5i406twr 161 35 this this DT cord-286607-5i406twr 161 36 mysterious mysterious JJ cord-286607-5i406twr 161 37 disorder disorder NN cord-286607-5i406twr 161 38 and and CC cord-286607-5i406twr 161 39 find find VB cord-286607-5i406twr 161 40 new new JJ cord-286607-5i406twr 161 41 targets target NNS cord-286607-5i406twr 161 42 for for IN cord-286607-5i406twr 161 43 identifying identify VBG cord-286607-5i406twr 161 44 disease disease NN cord-286607-5i406twr 161 45 - - HYPH cord-286607-5i406twr 161 46 modifying modify VBG cord-286607-5i406twr 161 47 agents agent NNS cord-286607-5i406twr 161 48 or or CC cord-286607-5i406twr 161 49 more more RBR cord-286607-5i406twr 161 50 specific specific JJ cord-286607-5i406twr 161 51 therapies therapy NNS cord-286607-5i406twr 161 52 . . . cord-286607-5i406twr 162 1 SE SE NNP cord-286607-5i406twr 162 2 , , , cord-286607-5i406twr 162 3 IP IP NNP cord-286607-5i406twr 162 4 , , , cord-286607-5i406twr 162 5 and and CC cord-286607-5i406twr 162 6 DR DR NNP cord-286607-5i406twr 162 7 contributed contribute VBD cord-286607-5i406twr 162 8 to to IN cord-286607-5i406twr 162 9 all all DT cord-286607-5i406twr 162 10 stages stage NNS cord-286607-5i406twr 162 11 of of IN cord-286607-5i406twr 162 12 the the DT cord-286607-5i406twr 162 13 preparation preparation NN cord-286607-5i406twr 162 14 of of IN cord-286607-5i406twr 162 15 this this DT cord-286607-5i406twr 162 16 manuscript manuscript NN cord-286607-5i406twr 162 17 , , , cord-286607-5i406twr 162 18 including include VBG cord-286607-5i406twr 162 19 conception conception NN cord-286607-5i406twr 162 20 and and CC cord-286607-5i406twr 162 21 writing writing NN cord-286607-5i406twr 162 22 . . . cord-286607-5i406twr 163 1 All all DT cord-286607-5i406twr 163 2 authors author NNS cord-286607-5i406twr 163 3 approved approve VBD cord-286607-5i406twr 163 4 the the DT cord-286607-5i406twr 163 5 final final JJ cord-286607-5i406twr 163 6 submitted submit VBN cord-286607-5i406twr 163 7 version version NN cord-286607-5i406twr 163 8 of of IN cord-286607-5i406twr 163 9 the the DT cord-286607-5i406twr 163 10 manuscript manuscript NN cord-286607-5i406twr 163 11 . . . cord-286607-5i406twr 164 1 Viral viral JJ cord-286607-5i406twr 164 2 infections infection NNS cord-286607-5i406twr 164 3 associated associate VBN cord-286607-5i406twr 164 4 with with IN cord-286607-5i406twr 164 5 Kawasaki Kawasaki NNP cord-286607-5i406twr 164 6 disease disease NN cord-286607-5i406twr 164 7 Epidemiology epidemiology NN cord-286607-5i406twr 164 8 , , , cord-286607-5i406twr 164 9 clinical clinical JJ cord-286607-5i406twr 164 10 presentation presentation NN cord-286607-5i406twr 164 11 , , , cord-286607-5i406twr 164 12 and and CC cord-286607-5i406twr 164 13 outcomes outcome NNS cord-286607-5i406twr 164 14 of of IN cord-286607-5i406twr 164 15 Kawasaki Kawasaki NNP cord-286607-5i406twr 164 16 disease disease NN cord-286607-5i406twr 164 17 among among IN cord-286607-5i406twr 164 18 hospitalized hospitalize VBN cord-286607-5i406twr 164 19 children child NNS cord-286607-5i406twr 164 20 in in IN cord-286607-5i406twr 164 21 an an DT cord-286607-5i406twr 164 22 inner inner JJ cord-286607-5i406twr 164 23 city city NN cord-286607-5i406twr 164 24 hospital hospital NN cord-286607-5i406twr 164 25 before before RB cord-286607-5i406twr 164 26 and and CC cord-286607-5i406twr 164 27 after after IN cord-286607-5i406twr 164 28 publication publication NN cord-286607-5i406twr 164 29 of of IN cord-286607-5i406twr 164 30 the the DT cord-286607-5i406twr 164 31 American American NNP cord-286607-5i406twr 164 32 Academy Academy NNP cord-286607-5i406twr 164 33 of of IN cord-286607-5i406twr 164 34 Pediatrics Pediatrics NNP cord-286607-5i406twr 164 35 / / SYM cord-286607-5i406twr 164 36 American American NNP cord-286607-5i406twr 164 37 Heart Heart NNP cord-286607-5i406twr 164 38 Association Association NNP cord-286607-5i406twr 164 39 Guidelines Guidelines NNPS cord-286607-5i406twr 164 40 for for IN cord-286607-5i406twr 164 41 treatment treatment NN cord-286607-5i406twr 164 42 of of IN cord-286607-5i406twr 164 43 Kawasaki Kawasaki NNP cord-286607-5i406twr 164 44 disease disease NN cord-286607-5i406twr 164 45 : : : cord-286607-5i406twr 164 46 an an DT cord-286607-5i406twr 164 47 11-year 11-year JJ cord-286607-5i406twr 164 48 period period NN cord-286607-5i406twr 164 49 A a DT cord-286607-5i406twr 164 50 new new JJ cord-286607-5i406twr 164 51 infantile infantile JJ cord-286607-5i406twr 164 52 acute acute JJ cord-286607-5i406twr 164 53 febrile febrile JJ cord-286607-5i406twr 164 54 mucocutaneous mucocutaneous JJ cord-286607-5i406twr 164 55 lymph lymph NN cord-286607-5i406twr 164 56 node node NN cord-286607-5i406twr 164 57 syndrome syndrome NN cord-286607-5i406twr 164 58 ( ( -LRB- cord-286607-5i406twr 164 59 MLNS MLNS NNP cord-286607-5i406twr 164 60 ) ) -RRB- cord-286607-5i406twr 164 61 prevailing prevail VBG cord-286607-5i406twr 164 62 in in IN cord-286607-5i406twr 164 63 Japan Japan NNP cord-286607-5i406twr 164 64 Kawasaki Kawasaki NNP cord-286607-5i406twr 164 65 disease disease NN cord-286607-5i406twr 164 66 : : : cord-286607-5i406twr 164 67 guidelines guideline NNS cord-286607-5i406twr 164 68 of of IN cord-286607-5i406twr 164 69 the the DT cord-286607-5i406twr 164 70 Italian Italian NNP cord-286607-5i406twr 164 71 Society Society NNP cord-286607-5i406twr 164 72 of of IN cord-286607-5i406twr 164 73 Pediatrics Pediatrics NNP cord-286607-5i406twr 164 74 , , , cord-286607-5i406twr 164 75 part part NN cord-286607-5i406twr 164 76 I i NN cord-286607-5i406twr 164 77 - - HYPH cord-286607-5i406twr 164 78 definition definition NN cord-286607-5i406twr 164 79 , , , cord-286607-5i406twr 164 80 epidemiology epidemiology NN cord-286607-5i406twr 164 81 , , , cord-286607-5i406twr 164 82 etiopathogenesis etiopathogenesis NN cord-286607-5i406twr 164 83 , , , cord-286607-5i406twr 164 84 clinical clinical JJ cord-286607-5i406twr 164 85 expression expression NN cord-286607-5i406twr 164 86 and and CC cord-286607-5i406twr 164 87 management management NN cord-286607-5i406twr 164 88 of of IN cord-286607-5i406twr 164 89 the the DT cord-286607-5i406twr 164 90 acute acute JJ cord-286607-5i406twr 164 91 phase phase NN cord-286607-5i406twr 164 92 Kawasaki Kawasaki NNP cord-286607-5i406twr 164 93 disease disease NN cord-286607-5i406twr 164 94 : : : cord-286607-5i406twr 164 95 guidelines guideline NNS cord-286607-5i406twr 164 96 of of IN cord-286607-5i406twr 164 97 Italian Italian NNP cord-286607-5i406twr 164 98 Society Society NNP cord-286607-5i406twr 164 99 of of IN cord-286607-5i406twr 164 100 Pediatrics Pediatrics NNP cord-286607-5i406twr 164 101 , , , cord-286607-5i406twr 164 102 part part NN cord-286607-5i406twr 164 103 II II NNP cord-286607-5i406twr 164 104 -treatment -treatment , cord-286607-5i406twr 164 105 of of IN cord-286607-5i406twr 164 106 resistant resistant JJ cord-286607-5i406twr 164 107 forms form NNS cord-286607-5i406twr 164 108 and and CC cord-286607-5i406twr 164 109 cardiovascular cardiovascular JJ cord-286607-5i406twr 164 110 complications complication NNS cord-286607-5i406twr 164 111 , , , cord-286607-5i406twr 164 112 follow follow NN cord-286607-5i406twr 164 113 - - HYPH cord-286607-5i406twr 164 114 up up NN cord-286607-5i406twr 164 115 , , , cord-286607-5i406twr 164 116 lifestyle lifestyle NN cord-286607-5i406twr 164 117 and and CC cord-286607-5i406twr 164 118 prevention prevention NN cord-286607-5i406twr 164 119 of of IN cord-286607-5i406twr 164 120 cardiovascular cardiovascular JJ cord-286607-5i406twr 164 121 risks risk NNS cord-286607-5i406twr 165 1 Current current JJ cord-286607-5i406twr 165 2 recommendations recommendation NNS cord-286607-5i406twr 165 3 for for IN cord-286607-5i406twr 165 4 the the DT cord-286607-5i406twr 165 5 pharmacologic pharmacologic JJ cord-286607-5i406twr 165 6 therapy therapy NN cord-286607-5i406twr 165 7 in in IN cord-286607-5i406twr 165 8 Kawasaki Kawasaki NNP cord-286607-5i406twr 165 9 syndrome syndrome NN cord-286607-5i406twr 165 10 and and CC cord-286607-5i406twr 165 11 management management NN cord-286607-5i406twr 165 12 of of IN cord-286607-5i406twr 165 13 its -PRON- PRP$ cord-286607-5i406twr 165 14 cardiovascular cardiovascular JJ cord-286607-5i406twr 165 15 complications complication NNS cord-286607-5i406twr 165 16 Responsiveness Responsiveness NNP cord-286607-5i406twr 165 17 to to IN cord-286607-5i406twr 165 18 intravenous intravenous JJ cord-286607-5i406twr 165 19 immunoglobulins immunoglobulin NNS cord-286607-5i406twr 165 20 and and CC cord-286607-5i406twr 165 21 occurrence occurrence NN cord-286607-5i406twr 165 22 of of IN cord-286607-5i406twr 165 23 coronary coronary JJ cord-286607-5i406twr 165 24 artery artery NN cord-286607-5i406twr 165 25 abnormalities abnormality NNS cord-286607-5i406twr 165 26 in in IN cord-286607-5i406twr 165 27 a a DT cord-286607-5i406twr 165 28 single single JJ cord-286607-5i406twr 165 29 - - HYPH cord-286607-5i406twr 165 30 center center NN cord-286607-5i406twr 165 31 cohort cohort NN cord-286607-5i406twr 165 32 of of IN cord-286607-5i406twr 165 33 Italian italian JJ cord-286607-5i406twr 165 34 patients patient NNS cord-286607-5i406twr 165 35 with with IN cord-286607-5i406twr 165 36 Kawasaki Kawasaki NNP cord-286607-5i406twr 165 37 syndrome syndrome NN cord-286607-5i406twr 165 38 Critical critical JJ cord-286607-5i406twr 165 39 overview overview NN cord-286607-5i406twr 165 40 of of IN cord-286607-5i406twr 165 41 the the DT cord-286607-5i406twr 165 42 risk risk NN cord-286607-5i406twr 165 43 scoring score VBG cord-286607-5i406twr 165 44 systems system NNS cord-286607-5i406twr 165 45 to to TO cord-286607-5i406twr 165 46 predict predict VB cord-286607-5i406twr 165 47 non non JJ cord-286607-5i406twr 165 48 - - JJ cord-286607-5i406twr 165 49 responsiveness responsiveness NN cord-286607-5i406twr 165 50 to to IN cord-286607-5i406twr 165 51 intravenous intravenous JJ cord-286607-5i406twr 165 52 immunoglobulin immunoglobulin NN cord-286607-5i406twr 165 53 in in IN cord-286607-5i406twr 165 54 Kawasaki Kawasaki NNP cord-286607-5i406twr 165 55 syndrome syndrome NN cord-286607-5i406twr 165 56 Kawasaki Kawasaki NNP cord-286607-5i406twr 165 57 disease disease NN cord-286607-5i406twr 165 58 incidence incidence NN cord-286607-5i406twr 165 59 in in IN cord-286607-5i406twr 165 60 children child NNS cord-286607-5i406twr 165 61 and and CC cord-286607-5i406twr 165 62 adolescents adolescent NNS cord-286607-5i406twr 165 63 : : : cord-286607-5i406twr 165 64 an an DT cord-286607-5i406twr 165 65 observational observational JJ cord-286607-5i406twr 165 66 study study NN cord-286607-5i406twr 165 67 in in IN cord-286607-5i406twr 165 68 primary primary JJ cord-286607-5i406twr 165 69 care care NN cord-286607-5i406twr 165 70 Epidemiologic epidemiologic JJ cord-286607-5i406twr 165 71 features feature NNS cord-286607-5i406twr 165 72 of of IN cord-286607-5i406twr 165 73 Kawasaki Kawasaki NNP cord-286607-5i406twr 165 74 disease disease NN cord-286607-5i406twr 165 75 in in IN cord-286607-5i406twr 165 76 Japan Japan NNP cord-286607-5i406twr 165 77 : : : cord-286607-5i406twr 165 78 results result NNS cord-286607-5i406twr 165 79 of of IN cord-286607-5i406twr 165 80 the the DT cord-286607-5i406twr 165 81 2009 2009 CD cord-286607-5i406twr 165 82 - - SYM cord-286607-5i406twr 165 83 10 10 CD cord-286607-5i406twr 165 84 nationwide nationwide JJ cord-286607-5i406twr 165 85 survey survey NN cord-286607-5i406twr 165 86 Kawasaki Kawasaki NNP cord-286607-5i406twr 165 87 disease disease NN cord-286607-5i406twr 165 88 : : : cord-286607-5i406twr 165 89 what what WP cord-286607-5i406twr 165 90 is be VBZ cord-286607-5i406twr 165 91 the the DT cord-286607-5i406twr 165 92 epidemiology epidemiology NN cord-286607-5i406twr 165 93 telling tell VBG cord-286607-5i406twr 165 94 us -PRON- PRP cord-286607-5i406twr 165 95 about about IN cord-286607-5i406twr 165 96 the the DT cord-286607-5i406twr 165 97 aetiology aetiology NN cord-286607-5i406twr 165 98 ? ? . cord-286607-5i406twr 166 1 The the DT cord-286607-5i406twr 166 2 role role NN cord-286607-5i406twr 166 3 of of IN cord-286607-5i406twr 166 4 infection infection NN cord-286607-5i406twr 166 5 in in IN cord-286607-5i406twr 166 6 Kawasaki Kawasaki NNP cord-286607-5i406twr 166 7 syndrome syndrome NN cord-286607-5i406twr 166 8 Viruses virus NNS cord-286607-5i406twr 166 9 and and CC cord-286607-5i406twr 166 10 the the DT cord-286607-5i406twr 166 11 microbiota microbiota NN cord-286607-5i406twr 166 12 Nationwide Nationwide NNP cord-286607-5i406twr 166 13 surveys survey NNS cord-286607-5i406twr 166 14 show show VBP cord-286607-5i406twr 166 15 that that IN cord-286607-5i406twr 166 16 the the DT cord-286607-5i406twr 166 17 incidence incidence NN cord-286607-5i406twr 166 18 of of IN cord-286607-5i406twr 166 19 recurrent recurrent JJ cord-286607-5i406twr 166 20 Kawasaki Kawasaki NNP cord-286607-5i406twr 166 21 disease disease NN cord-286607-5i406twr 166 22 in in IN cord-286607-5i406twr 166 23 Japan Japan NNP cord-286607-5i406twr 166 24 has have VBZ cord-286607-5i406twr 166 25 hardly hardly RB cord-286607-5i406twr 166 26 changed change VBN cord-286607-5i406twr 166 27 over over IN cord-286607-5i406twr 166 28 the the DT cord-286607-5i406twr 166 29 last last JJ cord-286607-5i406twr 166 30 30 30 CD cord-286607-5i406twr 166 31 years year NNS cord-286607-5i406twr 166 32 Dynamics dynamic NNS cord-286607-5i406twr 166 33 and and CC cord-286607-5i406twr 166 34 stabilization stabilization NN cord-286607-5i406twr 166 35 of of IN cord-286607-5i406twr 166 36 the the DT cord-286607-5i406twr 166 37 human human JJ cord-286607-5i406twr 166 38 gut gut NN cord-286607-5i406twr 166 39 microbiome microbiome NN cord-286607-5i406twr 166 40 during during IN cord-286607-5i406twr 166 41 the the DT cord-286607-5i406twr 166 42 first first JJ cord-286607-5i406twr 166 43 year year NN cord-286607-5i406twr 166 44 of of IN cord-286607-5i406twr 166 45 life life NN cord-286607-5i406twr 166 46 Succession Succession NNP cord-286607-5i406twr 166 47 of of IN cord-286607-5i406twr 166 48 microbial microbial JJ cord-286607-5i406twr 166 49 consortia consortium NNS cord-286607-5i406twr 166 50 in in IN cord-286607-5i406twr 166 51 the the DT cord-286607-5i406twr 166 52 developing develop VBG cord-286607-5i406twr 166 53 infant infant NN cord-286607-5i406twr 166 54 gut gut NN cord-286607-5i406twr 166 55 microbiome microbiome NN cord-286607-5i406twr 166 56 Functions function NNS cord-286607-5i406twr 166 57 of of IN cord-286607-5i406twr 166 58 intestinal intestinal JJ cord-286607-5i406twr 166 59 microflora microflora NN cord-286607-5i406twr 166 60 in in IN cord-286607-5i406twr 166 61 children child NNS cord-286607-5i406twr 166 62 Development Development NNP cord-286607-5i406twr 166 63 of of IN cord-286607-5i406twr 166 64 the the DT cord-286607-5i406twr 166 65 human human JJ cord-286607-5i406twr 166 66 infant infant NN cord-286607-5i406twr 166 67 intestinal intestinal JJ cord-286607-5i406twr 166 68 microbiota microbiota NNP cord-286607-5i406twr 166 69 Enterotypes Enterotypes NNP cord-286607-5i406twr 166 70 of of IN cord-286607-5i406twr 166 71 the the DT cord-286607-5i406twr 166 72 human human JJ cord-286607-5i406twr 166 73 gut gut NN cord-286607-5i406twr 166 74 microbiome microbiome NN cord-286607-5i406twr 167 1 Linking link VBG cord-286607-5i406twr 167 2 long long JJ cord-286607-5i406twr 167 3 - - HYPH cord-286607-5i406twr 167 4 term term NN cord-286607-5i406twr 167 5 dietary dietary JJ cord-286607-5i406twr 167 6 patterns pattern NNS cord-286607-5i406twr 167 7 with with IN cord-286607-5i406twr 167 8 gut gut NN cord-286607-5i406twr 167 9 microbial microbial JJ cord-286607-5i406twr 167 10 enterotypes enterotypes NNP cord-286607-5i406twr 167 11 Impact Impact NNP cord-286607-5i406twr 167 12 of of IN cord-286607-5i406twr 167 13 demographics demographic NNS cord-286607-5i406twr 167 14 on on IN cord-286607-5i406twr 167 15 human human JJ cord-286607-5i406twr 167 16 gut gut NN cord-286607-5i406twr 167 17 microbial microbial JJ cord-286607-5i406twr 167 18 diversity diversity NN cord-286607-5i406twr 167 19 in in IN cord-286607-5i406twr 167 20 a a DT cord-286607-5i406twr 167 21 US US NNP cord-286607-5i406twr 167 22 Midwest Midwest NNP cord-286607-5i406twr 167 23 population population NN cord-286607-5i406twr 168 1 A a DT cord-286607-5i406twr 168 2 core core NN cord-286607-5i406twr 168 3 gut gut NN cord-286607-5i406twr 168 4 microbiome microbiome NN cord-286607-5i406twr 168 5 in in IN cord-286607-5i406twr 168 6 obese obese JJ cord-286607-5i406twr 168 7 and and CC cord-286607-5i406twr 168 8 lean lean JJ cord-286607-5i406twr 168 9 twins twin NNS cord-286607-5i406twr 168 10 Detection detection NN cord-286607-5i406twr 168 11 of of IN cord-286607-5i406twr 168 12 potentially potentially RB cord-286607-5i406twr 168 13 novel novel JJ cord-286607-5i406twr 168 14 bacterial bacterial JJ cord-286607-5i406twr 168 15 components component NNS cord-286607-5i406twr 168 16 of of IN cord-286607-5i406twr 168 17 the the DT cord-286607-5i406twr 168 18 human human JJ cord-286607-5i406twr 168 19 skin skin NN cord-286607-5i406twr 168 20 microbiota microbiota NN cord-286607-5i406twr 168 21 using use VBG cord-286607-5i406twr 168 22 culture culture NN cord-286607-5i406twr 168 23 - - HYPH cord-286607-5i406twr 168 24 independent independent JJ cord-286607-5i406twr 168 25 molecular molecular JJ cord-286607-5i406twr 168 26 profiling profiling NN cord-286607-5i406twr 168 27 Culture culture NN cord-286607-5i406twr 168 28 - - HYPH cord-286607-5i406twr 168 29 independent independent JJ cord-286607-5i406twr 168 30 analysis analysis NN cord-286607-5i406twr 168 31 of of IN cord-286607-5i406twr 168 32 fecal fecal JJ cord-286607-5i406twr 168 33 microbiota microbiota NN cord-286607-5i406twr 168 34 in in IN cord-286607-5i406twr 168 35 infants infant NNS cord-286607-5i406twr 168 36 , , , cord-286607-5i406twr 168 37 with with IN cord-286607-5i406twr 168 38 special special JJ cord-286607-5i406twr 168 39 reference reference NN cord-286607-5i406twr 168 40 to to IN cord-286607-5i406twr 168 41 Bifidobacterium bifidobacterium NN cord-286607-5i406twr 168 42 species specie NNS cord-286607-5i406twr 169 1 Has have VBZ cord-286607-5i406twr 169 2 the the DT cord-286607-5i406twr 169 3 microbiota microbiota NN cord-286607-5i406twr 169 4 played play VBN cord-286607-5i406twr 169 5 a a DT cord-286607-5i406twr 169 6 critical critical JJ cord-286607-5i406twr 169 7 role role NN cord-286607-5i406twr 169 8 in in IN cord-286607-5i406twr 169 9 the the DT cord-286607-5i406twr 169 10 evolution evolution NN cord-286607-5i406twr 169 11 of of IN cord-286607-5i406twr 169 12 the the DT cord-286607-5i406twr 169 13 adaptive adaptive JJ cord-286607-5i406twr 169 14 immune immune JJ cord-286607-5i406twr 169 15 system system NN cord-286607-5i406twr 169 16 ? ? . cord-286607-5i406twr 170 1 Unbalance unbalance NN cord-286607-5i406twr 170 2 of of IN cord-286607-5i406twr 170 3 intestinal intestinal JJ cord-286607-5i406twr 170 4 microbiota microbiota NN cord-286607-5i406twr 170 5 in in IN cord-286607-5i406twr 170 6 atopic atopic JJ cord-286607-5i406twr 170 7 children child NNS cord-286607-5i406twr 170 8 Altered alter VBD cord-286607-5i406twr 170 9 early early JJ cord-286607-5i406twr 170 10 infant infant NN cord-286607-5i406twr 170 11 gut gut NN cord-286607-5i406twr 170 12 microbiota microbiota NN cord-286607-5i406twr 170 13 in in IN cord-286607-5i406twr 170 14 children child NNS cord-286607-5i406twr 170 15 developing develop VBG cord-286607-5i406twr 170 16 allergy allergy NN cord-286607-5i406twr 170 17 up up IN cord-286607-5i406twr 170 18 to to TO cord-286607-5i406twr 170 19 5 5 CD cord-286607-5i406twr 170 20 years year NNS cord-286607-5i406twr 170 21 of of IN cord-286607-5i406twr 170 22 age age NN cord-286607-5i406twr 170 23 Antibiotic Antibiotic NNP cord-286607-5i406twr 170 24 - - HYPH cord-286607-5i406twr 170 25 induced induce VBN cord-286607-5i406twr 170 26 dysbiosis dysbiosis NN cord-286607-5i406twr 171 1 alters alter VBZ cord-286607-5i406twr 171 2 host host NN cord-286607-5i406twr 171 3 - - HYPH cord-286607-5i406twr 171 4 bacterial bacterial JJ cord-286607-5i406twr 171 5 interactions interaction NNS cord-286607-5i406twr 171 6 and and CC cord-286607-5i406twr 171 7 leads lead VBZ cord-286607-5i406twr 171 8 to to IN cord-286607-5i406twr 171 9 colonic colonic JJ cord-286607-5i406twr 171 10 sensory sensory JJ cord-286607-5i406twr 171 11 and and CC cord-286607-5i406twr 171 12 motor motor NN cord-286607-5i406twr 171 13 changes change NNS cord-286607-5i406twr 171 14 in in IN cord-286607-5i406twr 171 15 mice mouse NNS cord-286607-5i406twr 171 16 Host Host NNP cord-286607-5i406twr 171 17 microbe microbe NN cord-286607-5i406twr 171 18 interactions interaction NNS cord-286607-5i406twr 171 19 in in IN cord-286607-5i406twr 171 20 the the DT cord-286607-5i406twr 171 21 small small JJ cord-286607-5i406twr 171 22 bowel bowel NN cord-286607-5i406twr 171 23 Human Human NNP cord-286607-5i406twr 171 24 Microbiome Microbiome NNP cord-286607-5i406twr 171 25 Project Project NNP cord-286607-5i406twr 171 26 Consortium Consortium NNP cord-286607-5i406twr 171 27 . . . cord-286607-5i406twr 172 1 Structure structure NN cord-286607-5i406twr 172 2 , , , cord-286607-5i406twr 172 3 function function NN cord-286607-5i406twr 172 4 and and CC cord-286607-5i406twr 172 5 diversity diversity NN cord-286607-5i406twr 172 6 of of IN cord-286607-5i406twr 172 7 the the DT cord-286607-5i406twr 172 8 healthy healthy JJ cord-286607-5i406twr 172 9 human human JJ cord-286607-5i406twr 172 10 microbiome microbiome NN cord-286607-5i406twr 172 11 Microbiota Microbiota NNP cord-286607-5i406twr 172 12 activation activation NN cord-286607-5i406twr 172 13 and and CC cord-286607-5i406twr 172 14 regulation regulation NN cord-286607-5i406twr 172 15 of of IN cord-286607-5i406twr 172 16 innate innate JJ cord-286607-5i406twr 172 17 and and CC cord-286607-5i406twr 172 18 adaptative adaptative JJ cord-286607-5i406twr 172 19 immunity immunity NN cord-286607-5i406twr 172 20 Microbiota Microbiota NNP cord-286607-5i406twr 172 21 in in IN cord-286607-5i406twr 172 22 pediatric pediatric JJ cord-286607-5i406twr 172 23 inflammatory inflammatory JJ cord-286607-5i406twr 172 24 bowel bowel NN cord-286607-5i406twr 172 25 disease disease NN cord-286607-5i406twr 172 26 Intestinal intestinal JJ cord-286607-5i406twr 172 27 dysbiosis dysbiosis NN cord-286607-5i406twr 172 28 and and CC cord-286607-5i406twr 172 29 reduced reduce VBN cord-286607-5i406twr 172 30 immunoglobulin immunoglobulin NN cord-286607-5i406twr 172 31 - - HYPH cord-286607-5i406twr 172 32 coated coat VBN cord-286607-5i406twr 172 33 bacteria bacteria NNS cord-286607-5i406twr 172 34 associated associate VBN cord-286607-5i406twr 172 35 with with IN cord-286607-5i406twr 172 36 coeliac coeliac JJ cord-286607-5i406twr 172 37 disease disease NN cord-286607-5i406twr 172 38 in in IN cord-286607-5i406twr 172 39 children child NNS cord-286607-5i406twr 172 40 A a DT cord-286607-5i406twr 172 41 distinctive distinctive JJ cord-286607-5i406twr 172 42 ' ' `` cord-286607-5i406twr 172 43 microbial microbial JJ cord-286607-5i406twr 172 44 signature signature NN cord-286607-5i406twr 172 45 ' ' '' cord-286607-5i406twr 172 46 in in IN cord-286607-5i406twr 172 47 celiac celiac JJ cord-286607-5i406twr 172 48 pediatric pediatric JJ cord-286607-5i406twr 172 49 patients patient NNS cord-286607-5i406twr 173 1 The the DT cord-286607-5i406twr 173 2 role role NN cord-286607-5i406twr 173 3 of of IN cord-286607-5i406twr 173 4 small small JJ cord-286607-5i406twr 173 5 intestinal intestinal JJ cord-286607-5i406twr 173 6 bacterial bacterial JJ cord-286607-5i406twr 173 7 overgrowth overgrowth NN cord-286607-5i406twr 173 8 , , , cord-286607-5i406twr 173 9 intestinal intestinal JJ cord-286607-5i406twr 173 10 permeability permeability NN cord-286607-5i406twr 173 11 , , , cord-286607-5i406twr 173 12 endotoxaemia endotoxaemia NN cord-286607-5i406twr 173 13 , , , cord-286607-5i406twr 173 14 and and CC cord-286607-5i406twr 173 15 tumour tumour NN cord-286607-5i406twr 173 16 necrosis necrosis NN cord-286607-5i406twr 173 17 factor factor NN cord-286607-5i406twr 173 18 alpha alpha NN cord-286607-5i406twr 173 19 in in IN cord-286607-5i406twr 173 20 the the DT cord-286607-5i406twr 173 21 pathogenesis pathogenesis NN cord-286607-5i406twr 173 22 of of IN cord-286607-5i406twr 173 23 non non JJ cord-286607-5i406twr 173 24 - - JJ cord-286607-5i406twr 173 25 alcoholic alcoholic JJ cord-286607-5i406twr 173 26 steatohepatitis steatohepatitis NN cord-286607-5i406twr 173 27 Autoinflammatory Autoinflammatory NNP cord-286607-5i406twr 173 28 diseases disease NNS cord-286607-5i406twr 174 1 A a DT cord-286607-5i406twr 174 2 systematic systematic JJ cord-286607-5i406twr 174 3 approach approach NN cord-286607-5i406twr 174 4 to to IN cord-286607-5i406twr 174 5 autoinflammatory autoinflammatory NNP cord-286607-5i406twr 174 6 syndromes syndrome NNS cord-286607-5i406twr 174 7 : : : cord-286607-5i406twr 174 8 a a DT cord-286607-5i406twr 174 9 spelling spelling NN cord-286607-5i406twr 174 10 booklet booklet NN cord-286607-5i406twr 174 11 for for IN cord-286607-5i406twr 174 12 the the DT cord-286607-5i406twr 174 13 beginner beginner JJ cord-286607-5i406twr 174 14 A a DT cord-286607-5i406twr 174 15 developing develop VBG cord-286607-5i406twr 174 16 portrait portrait NN cord-286607-5i406twr 174 17 of of IN cord-286607-5i406twr 174 18 hereditary hereditary JJ cord-286607-5i406twr 174 19 periodic periodic JJ cord-286607-5i406twr 174 20 fevers fever NNS cord-286607-5i406twr 174 21 in in IN cord-286607-5i406twr 174 22 childhood childhood NN cord-286607-5i406twr 175 1 The the DT cord-286607-5i406twr 175 2 broad broad RB cord-286607-5i406twr 175 3 - - HYPH cord-286607-5i406twr 175 4 ranging range VBG cord-286607-5i406twr 175 5 panorama panorama NN cord-286607-5i406twr 175 6 of of IN cord-286607-5i406twr 175 7 systemic systemic JJ cord-286607-5i406twr 175 8 autoinflammatory autoinflammatory JJ cord-286607-5i406twr 175 9 disorders disorder NNS cord-286607-5i406twr 175 10 with with IN cord-286607-5i406twr 175 11 specific specific JJ cord-286607-5i406twr 175 12 focus focus NN cord-286607-5i406twr 175 13 on on IN cord-286607-5i406twr 175 14 acute acute JJ cord-286607-5i406twr 175 15 painful painful JJ cord-286607-5i406twr 175 16 symptoms symptom NNS cord-286607-5i406twr 175 17 and and CC cord-286607-5i406twr 175 18 hematologic hematologic JJ cord-286607-5i406twr 175 19 manifestations manifestation NNS cord-286607-5i406twr 175 20 in in IN cord-286607-5i406twr 175 21 children child NNS cord-286607-5i406twr 175 22 Kawasaki Kawasaki NNP cord-286607-5i406twr 175 23 syndrome syndrome NN cord-286607-5i406twr 175 24 : : : cord-286607-5i406twr 175 25 an an DT cord-286607-5i406twr 175 26 intriguing intriguing JJ cord-286607-5i406twr 175 27 disease disease NN cord-286607-5i406twr 175 28 with with IN cord-286607-5i406twr 175 29 numerous numerous JJ cord-286607-5i406twr 175 30 unsolved unsolved JJ cord-286607-5i406twr 175 31 dilemmas dilemma NNS cord-286607-5i406twr 175 32 Non non JJ cord-286607-5i406twr 175 33 - - JJ cord-286607-5i406twr 175 34 infectious infectious JJ cord-286607-5i406twr 175 35 makers maker NNS cord-286607-5i406twr 175 36 of of IN cord-286607-5i406twr 175 37 Kawasaki Kawasaki NNP cord-286607-5i406twr 175 38 syndrome syndrome NN cord-286607-5i406twr 175 39 : : : cord-286607-5i406twr 175 40 tangible tangible JJ cord-286607-5i406twr 175 41 or or CC cord-286607-5i406twr 175 42 elusive elusive JJ cord-286607-5i406twr 175 43 triggers trigger NNS cord-286607-5i406twr 175 44 ? ? . cord-286607-5i406twr 176 1 Is be VBZ cord-286607-5i406twr 176 2 Kawasaki Kawasaki NNP cord-286607-5i406twr 176 3 disease disease NN cord-286607-5i406twr 176 4 an an DT cord-286607-5i406twr 176 5 infectious infectious JJ cord-286607-5i406twr 176 6 disorder disorder NN cord-286607-5i406twr 176 7 ? ? . cord-286607-5i406twr 177 1 Kawasaki Kawasaki NNP cord-286607-5i406twr 177 2 disease disease NN cord-286607-5i406twr 177 3 : : : cord-286607-5i406twr 177 4 epidemiology epidemiology NN cord-286607-5i406twr 177 5 and and CC cord-286607-5i406twr 177 6 the the DT cord-286607-5i406twr 177 7 lessons lesson NNS cord-286607-5i406twr 177 8 from from IN cord-286607-5i406twr 177 9 it -PRON- PRP cord-286607-5i406twr 178 1 Kawasaki Kawasaki NNP cord-286607-5i406twr 178 2 syndrome syndrome NN cord-286607-5i406twr 179 1 A a DT cord-286607-5i406twr 179 2 master master NN cord-286607-5i406twr 179 3 role role NN cord-286607-5i406twr 179 4 for for IN cord-286607-5i406twr 179 5 neutrophils neutrophil NNS cord-286607-5i406twr 179 6 in in IN cord-286607-5i406twr 179 7 Kawasaki Kawasaki NNP cord-286607-5i406twr 179 8 syndrome syndrome NN cord-286607-5i406twr 179 9 Environmental environmental JJ cord-286607-5i406twr 179 10 epidemiology epidemiology NN cord-286607-5i406twr 179 11 of of IN cord-286607-5i406twr 179 12 Kawasaki Kawasaki NNP cord-286607-5i406twr 179 13 disease disease NN cord-286607-5i406twr 179 14 : : : cord-286607-5i406twr 179 15 linking link VBG cord-286607-5i406twr 179 16 disease disease NN cord-286607-5i406twr 179 17 etiology etiology NN cord-286607-5i406twr 179 18 , , , cord-286607-5i406twr 179 19 pathogenesis pathogenesis NN cord-286607-5i406twr 179 20 and and CC cord-286607-5i406twr 179 21 global global JJ cord-286607-5i406twr 179 22 distribution distribution NN cord-286607-5i406twr 179 23 Increased increase VBN cord-286607-5i406twr 179 24 levels level NNS cord-286607-5i406twr 179 25 of of IN cord-286607-5i406twr 179 26 lipopolysaccharide lipopolysaccharide NN cord-286607-5i406twr 179 27 binding bind VBG cord-286607-5i406twr 179 28 protein protein NN cord-286607-5i406twr 179 29 in in IN cord-286607-5i406twr 179 30 plasma plasma NN cord-286607-5i406twr 179 31 in in IN cord-286607-5i406twr 179 32 children child NNS cord-286607-5i406twr 179 33 with with IN cord-286607-5i406twr 179 34 Kawasaki Kawasaki NNP cord-286607-5i406twr 179 35 disease disease NN cord-286607-5i406twr 180 1 Endothelial endothelial JJ cord-286607-5i406twr 180 2 NLRP3 nlrp3 XX cord-286607-5i406twr 181 1 inflammasome inflammasome NNP cord-286607-5i406twr 181 2 activation activation NN cord-286607-5i406twr 181 3 associated associate VBN cord-286607-5i406twr 181 4 with with IN cord-286607-5i406twr 181 5 lysosomal lysosomal JJ cord-286607-5i406twr 181 6 destabilization destabilization NN cord-286607-5i406twr 181 7 during during IN cord-286607-5i406twr 181 8 coronary coronary JJ cord-286607-5i406twr 181 9 arteritis arteritis NN cord-286607-5i406twr 181 10 Endothelial Endothelial NNP cord-286607-5i406twr 181 11 NLRP3 NLRP3 NNP cord-286607-5i406twr 181 12 inflammasome inflammasome NN cord-286607-5i406twr 181 13 activation activation NN cord-286607-5i406twr 181 14 and and CC cord-286607-5i406twr 181 15 enhanced enhance VBN cord-286607-5i406twr 181 16 neointima neointima NNP cord-286607-5i406twr 181 17 formation formation NN cord-286607-5i406twr 181 18 in in IN cord-286607-5i406twr 181 19 mice mouse NNS cord-286607-5i406twr 181 20 by by IN cord-286607-5i406twr 181 21 adipokine adipokine NNP cord-286607-5i406twr 181 22 visfatin visfatin NNP cord-286607-5i406twr 182 1 Clonal clonal JJ cord-286607-5i406twr 182 2 expansion expansion NN cord-286607-5i406twr 182 3 of of IN cord-286607-5i406twr 182 4 CD8 CD8 NNP cord-286607-5i406twr 182 5 + + CC cord-286607-5i406twr 182 6 T T NNP cord-286607-5i406twr 182 7 cells cell NNS cord-286607-5i406twr 182 8 in in IN cord-286607-5i406twr 182 9 Kawasaki Kawasaki NNP cord-286607-5i406twr 182 10 disease disease NN cord-286607-5i406twr 183 1 The the DT cord-286607-5i406twr 183 2 transcriptional transcriptional JJ cord-286607-5i406twr 183 3 profile profile NN cord-286607-5i406twr 183 4 of of IN cord-286607-5i406twr 183 5 coronary coronary JJ cord-286607-5i406twr 183 6 arteritis arteritis NN cord-286607-5i406twr 183 7 in in IN cord-286607-5i406twr 183 8 Kawasaki Kawasaki NNP cord-286607-5i406twr 183 9 disease disease NN cord-286607-5i406twr 183 10 Kawasaki Kawasaki NNP cord-286607-5i406twr 183 11 disease disease NN cord-286607-5i406twr 183 12 : : : cord-286607-5i406twr 183 13 current current JJ cord-286607-5i406twr 183 14 aspects aspect NNS cord-286607-5i406twr 183 15 on on IN cord-286607-5i406twr 183 16 aetiopathogenesis aetiopathogenesis NNP cord-286607-5i406twr 183 17 and and CC cord-286607-5i406twr 183 18 therapeutic therapeutic JJ cord-286607-5i406twr 183 19 management management NN cord-286607-5i406twr 183 20 Ultrastructural Ultrastructural NNP cord-286607-5i406twr 183 21 , , , cord-286607-5i406twr 183 22 immunofluorescence immunofluorescence NN cord-286607-5i406twr 183 23 , , , cord-286607-5i406twr 183 24 and and CC cord-286607-5i406twr 183 25 RNA RNA NNP cord-286607-5i406twr 183 26 evidence evidence NN cord-286607-5i406twr 183 27 support support VBP cord-286607-5i406twr 183 28 the the DT cord-286607-5i406twr 183 29 hypothesis hypothesis NN cord-286607-5i406twr 183 30 of of IN cord-286607-5i406twr 183 31 a a DT cord-286607-5i406twr 183 32 " " `` cord-286607-5i406twr 183 33 new new JJ cord-286607-5i406twr 183 34 " " '' cord-286607-5i406twr 183 35 virus virus NN cord-286607-5i406twr 183 36 associated associate VBN cord-286607-5i406twr 183 37 with with IN cord-286607-5i406twr 183 38 Kawasaki Kawasaki NNP cord-286607-5i406twr 183 39 disease disease NN cord-286607-5i406twr 183 40 RNA RNA NNP cord-286607-5i406twr 183 41 - - HYPH cord-286607-5i406twr 183 42 containing contain VBG cord-286607-5i406twr 183 43 cytoplasmic cytoplasmic JJ cord-286607-5i406twr 183 44 inclusion inclusion NN cord-286607-5i406twr 183 45 bodies body NNS cord-286607-5i406twr 183 46 in in IN cord-286607-5i406twr 183 47 ciliated ciliated JJ cord-286607-5i406twr 183 48 bronchial bronchial JJ cord-286607-5i406twr 183 49 epithelium epithelium NN cord-286607-5i406twr 183 50 months month NNS cord-286607-5i406twr 183 51 to to IN cord-286607-5i406twr 183 52 years year NNS cord-286607-5i406twr 183 53 after after IN cord-286607-5i406twr 183 54 acute acute JJ cord-286607-5i406twr 183 55 Kawasaki Kawasaki NNP cord-286607-5i406twr 183 56 disease disease NN cord-286607-5i406twr 183 57 Cytoplasmic Cytoplasmic NNP cord-286607-5i406twr 183 58 inclusion inclusion NN cord-286607-5i406twr 183 59 bodies body NNS cord-286607-5i406twr 183 60 are be VBP cord-286607-5i406twr 183 61 detected detect VBN cord-286607-5i406twr 183 62 by by IN cord-286607-5i406twr 183 63 synthetic synthetic JJ cord-286607-5i406twr 183 64 antibody antibody NN cord-286607-5i406twr 183 65 in in IN cord-286607-5i406twr 183 66 ciliated ciliated JJ cord-286607-5i406twr 183 67 bronchial bronchial JJ cord-286607-5i406twr 183 68 epithelium epithelium NN cord-286607-5i406twr 183 69 during during IN cord-286607-5i406twr 183 70 acute acute JJ cord-286607-5i406twr 183 71 Kawasaki Kawasaki NNP cord-286607-5i406twr 183 72 disease disease NN cord-286607-5i406twr 183 73 IgA IgA NNP cord-286607-5i406twr 183 74 plasma plasma NN cord-286607-5i406twr 183 75 cells cell NNS cord-286607-5i406twr 183 76 in in IN cord-286607-5i406twr 183 77 vascular vascular JJ cord-286607-5i406twr 183 78 tissue tissue NN cord-286607-5i406twr 183 79 of of IN cord-286607-5i406twr 183 80 patients patient NNS cord-286607-5i406twr 183 81 with with IN cord-286607-5i406twr 183 82 Kawasaki Kawasaki NNP cord-286607-5i406twr 183 83 syndrome syndrome NN cord-286607-5i406twr 184 1 Concurrent concurrent JJ cord-286607-5i406twr 184 2 respiratory respiratory JJ cord-286607-5i406twr 184 3 viruses virus NNS cord-286607-5i406twr 184 4 and and CC cord-286607-5i406twr 184 5 Kawasaki Kawasaki NNP cord-286607-5i406twr 184 6 disease disease NN cord-286607-5i406twr 184 7 Association Association NNP cord-286607-5i406twr 184 8 between between IN cord-286607-5i406twr 184 9 a a DT cord-286607-5i406twr 184 10 novel novel JJ cord-286607-5i406twr 184 11 human human JJ cord-286607-5i406twr 184 12 coronavirus coronavirus NN cord-286607-5i406twr 184 13 and and CC cord-286607-5i406twr 184 14 Kawasaki Kawasaki NNP cord-286607-5i406twr 184 15 disease disease NN cord-286607-5i406twr 184 16 Human human JJ cord-286607-5i406twr 184 17 coronavirus coronavirus NN cord-286607-5i406twr 185 1 NL63 NL63 NNP cord-286607-5i406twr 185 2 is be VBZ cord-286607-5i406twr 185 3 not not RB cord-286607-5i406twr 185 4 detected detect VBN cord-286607-5i406twr 185 5 in in IN cord-286607-5i406twr 185 6 the the DT cord-286607-5i406twr 185 7 respiratory respiratory JJ cord-286607-5i406twr 185 8 tracts tract NNS cord-286607-5i406twr 185 9 of of IN cord-286607-5i406twr 185 10 children child NNS cord-286607-5i406twr 185 11 with with IN cord-286607-5i406twr 185 12 acute acute JJ cord-286607-5i406twr 185 13 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 14 disease disease NN cord-286607-5i406twr 185 15 Lack Lack NNP cord-286607-5i406twr 185 16 of of IN cord-286607-5i406twr 185 17 association association NN cord-286607-5i406twr 185 18 between between IN cord-286607-5i406twr 185 19 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 20 syndrome syndrome NN cord-286607-5i406twr 185 21 and and CC cord-286607-5i406twr 185 22 infection infection NN cord-286607-5i406twr 185 23 with with IN cord-286607-5i406twr 185 24 parvovirus parvovirus NN cord-286607-5i406twr 185 25 B19 B19 NNP cord-286607-5i406twr 185 26 , , , cord-286607-5i406twr 185 27 human human JJ cord-286607-5i406twr 185 28 herpes herpes NN cord-286607-5i406twr 185 29 - - HYPH cord-286607-5i406twr 185 30 virus virus NN cord-286607-5i406twr 185 31 8 8 CD cord-286607-5i406twr 185 32 , , , cord-286607-5i406twr 185 33 TT TT NNP cord-286607-5i406twr 185 34 virus virus NN cord-286607-5i406twr 185 35 , , , cord-286607-5i406twr 185 36 GB GB NNP cord-286607-5i406twr 185 37 virus virus NN cord-286607-5i406twr 185 38 C c NN cord-286607-5i406twr 185 39 / / SYM cord-286607-5i406twr 185 40 hepatitis hepatitis NN cord-286607-5i406twr 185 41 G g NN cord-286607-5i406twr 185 42 virus virus NN cord-286607-5i406twr 185 43 or or CC cord-286607-5i406twr 185 44 Chlamydia Chlamydia NNP cord-286607-5i406twr 185 45 pneumoniae pneumoniae NN cord-286607-5i406twr 185 46 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 47 disease disease NN cord-286607-5i406twr 185 48 with with IN cord-286607-5i406twr 185 49 a a DT cord-286607-5i406twr 185 50 concomitant concomitant JJ cord-286607-5i406twr 185 51 primary primary JJ cord-286607-5i406twr 185 52 Epstein Epstein NNP cord-286607-5i406twr 185 53 - - HYPH cord-286607-5i406twr 185 54 Barr Barr NNP cord-286607-5i406twr 185 55 virus virus NN cord-286607-5i406twr 185 56 infection infection NN cord-286607-5i406twr 185 57 Adenovirus Adenovirus NNP cord-286607-5i406twr 185 58 type type NN cord-286607-5i406twr 185 59 2 2 CD cord-286607-5i406twr 185 60 isolated isolate VBN cord-286607-5i406twr 185 61 from from IN cord-286607-5i406twr 185 62 a a DT cord-286607-5i406twr 185 63 patient patient NN cord-286607-5i406twr 185 64 with with IN cord-286607-5i406twr 185 65 fatal fatal JJ cord-286607-5i406twr 185 66 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 67 disease disease NN cord-286607-5i406twr 185 68 Isolation isolation NN cord-286607-5i406twr 185 69 of of IN cord-286607-5i406twr 185 70 human human JJ cord-286607-5i406twr 185 71 herpesvirus-6 herpesvirus-6 NNP cord-286607-5i406twr 185 72 from from IN cord-286607-5i406twr 185 73 an an DT cord-286607-5i406twr 185 74 infant infant NN cord-286607-5i406twr 185 75 with with IN cord-286607-5i406twr 185 76 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 77 disease disease NN cord-286607-5i406twr 185 78 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 79 disease disease NN cord-286607-5i406twr 185 80 associated associate VBN cord-286607-5i406twr 185 81 with with IN cord-286607-5i406twr 185 82 measles measle NNS cord-286607-5i406twr 185 83 virus virus NN cord-286607-5i406twr 185 84 infection infection NN cord-286607-5i406twr 185 85 in in IN cord-286607-5i406twr 185 86 a a DT cord-286607-5i406twr 185 87 monozygotic monozygotic JJ cord-286607-5i406twr 185 88 twin twin JJ cord-286607-5i406twr 185 89 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 90 disease disease NN cord-286607-5i406twr 185 91 associated associate VBN cord-286607-5i406twr 185 92 with with IN cord-286607-5i406twr 185 93 Klebsiella Klebsiella NNP cord-286607-5i406twr 185 94 pneumoniae pneumoniae NN cord-286607-5i406twr 185 95 bacteremia bacteremia NN cord-286607-5i406twr 185 96 and and CC cord-286607-5i406twr 185 97 parainfluenza parainfluenza NNP cord-286607-5i406twr 185 98 type type NNP cord-286607-5i406twr 185 99 3 3 CD cord-286607-5i406twr 185 100 virus virus NN cord-286607-5i406twr 185 101 infection infection NN cord-286607-5i406twr 185 102 Concomitant concomitant JJ cord-286607-5i406twr 185 103 dengue dengue NN cord-286607-5i406twr 185 104 hemorrhagic hemorrhagic JJ cord-286607-5i406twr 185 105 fever fever NN cord-286607-5i406twr 185 106 with with IN cord-286607-5i406twr 185 107 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 108 disease disease NN cord-286607-5i406twr 185 109 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 110 disease disease NN cord-286607-5i406twr 185 111 coincident coincident JJ cord-286607-5i406twr 185 112 with with IN cord-286607-5i406twr 185 113 influenza influenza NN cord-286607-5i406twr 185 114 A a DT cord-286607-5i406twr 185 115 H1N1/09 h1n1/09 JJ cord-286607-5i406twr 185 116 infection infection NN cord-286607-5i406twr 185 117 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 118 syndrome syndrome NN cord-286607-5i406twr 185 119 and and CC cord-286607-5i406twr 185 120 concurrent concurrent JJ cord-286607-5i406twr 185 121 Coxsackie Coxsackie NNP cord-286607-5i406twr 185 122 - - HYPH cord-286607-5i406twr 185 123 virus virus NN cord-286607-5i406twr 185 124 B3 b3 NN cord-286607-5i406twr 185 125 infection infection NN cord-286607-5i406twr 185 126 Clinical clinical JJ cord-286607-5i406twr 185 127 and and CC cord-286607-5i406twr 185 128 virologic virologic JJ cord-286607-5i406twr 185 129 characteristics characteristic NNS cord-286607-5i406twr 185 130 may may MD cord-286607-5i406twr 185 131 aid aid VB cord-286607-5i406twr 185 132 distinction distinction NN cord-286607-5i406twr 185 133 of of IN cord-286607-5i406twr 185 134 acute acute JJ cord-286607-5i406twr 185 135 adenovirus adenovirus NN cord-286607-5i406twr 185 136 disease disease NN cord-286607-5i406twr 185 137 from from IN cord-286607-5i406twr 185 138 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 139 disease disease NN cord-286607-5i406twr 185 140 with with IN cord-286607-5i406twr 185 141 incidental incidental JJ cord-286607-5i406twr 185 142 adenovirus adenovirus NN cord-286607-5i406twr 185 143 detection detection NN cord-286607-5i406twr 185 144 Human human JJ cord-286607-5i406twr 185 145 adenovirus adenovirus NN cord-286607-5i406twr 185 146 infection infection NN cord-286607-5i406twr 185 147 in in IN cord-286607-5i406twr 185 148 Kawasaki Kawasaki NNP cord-286607-5i406twr 185 149 disease disease NN cord-286607-5i406twr 185 150 : : : cord-286607-5i406twr 185 151 a a DT cord-286607-5i406twr 185 152 confounding confound VBG cord-286607-5i406twr 185 153 bystander bystander NN cord-286607-5i406twr 185 154 ? ? . cord-286607-5i406twr 186 1 Cytomegalovirus Cytomegalovirus NNP cord-286607-5i406twr 186 2 infection infection NN cord-286607-5i406twr 186 3 in in IN cord-286607-5i406twr 186 4 a a DT cord-286607-5i406twr 186 5 patient patient NN cord-286607-5i406twr 186 6 with with IN cord-286607-5i406twr 186 7 atypical atypical JJ cord-286607-5i406twr 186 8 Kawasaki Kawasaki NNP cord-286607-5i406twr 186 9 disease disease NN cord-286607-5i406twr 186 10 Markers marker NNS cord-286607-5i406twr 186 11 of of IN cord-286607-5i406twr 186 12 a a DT cord-286607-5i406twr 186 13 recent recent JJ cord-286607-5i406twr 186 14 bocavirus bocavirus NN cord-286607-5i406twr 186 15 infection infection NN cord-286607-5i406twr 186 16 in in IN cord-286607-5i406twr 186 17 children child NNS cord-286607-5i406twr 186 18 with with IN cord-286607-5i406twr 186 19 Kawasaki Kawasaki NNP cord-286607-5i406twr 186 20 disease disease NN cord-286607-5i406twr 186 21 Polyclonal Polyclonal NNP cord-286607-5i406twr 186 22 expansion expansion NN cord-286607-5i406twr 186 23 of of IN cord-286607-5i406twr 186 24 TCRBV2-and TCRBV2-and NNP cord-286607-5i406twr 186 25 TCRBV6-bearing TCRBV6-bearing NNP cord-286607-5i406twr 186 26 T t NN cord-286607-5i406twr 186 27 cells cell NNS cord-286607-5i406twr 186 28 in in IN cord-286607-5i406twr 186 29 patients patient NNS cord-286607-5i406twr 186 30 with with IN cord-286607-5i406twr 186 31 Kawasaki Kawasaki NNP cord-286607-5i406twr 186 32 disease disease NN cord-286607-5i406twr 186 33 Prevalence prevalence NN cord-286607-5i406twr 186 34 of of IN cord-286607-5i406twr 186 35 superantigen superantigen NN cord-286607-5i406twr 186 36 - - HYPH cord-286607-5i406twr 186 37 secreting secrete VBG cord-286607-5i406twr 186 38 bacteria bacteria NNS cord-286607-5i406twr 186 39 in in IN cord-286607-5i406twr 186 40 patients patient NNS cord-286607-5i406twr 186 41 with with IN cord-286607-5i406twr 186 42 Kawasaki Kawasaki NNP cord-286607-5i406twr 186 43 disease disease NN cord-286607-5i406twr 186 44 Development Development NNP cord-286607-5i406twr 186 45 of of IN cord-286607-5i406twr 186 46 serum serum NNP cord-286607-5i406twr 186 47 IgM IgM NNP cord-286607-5i406twr 186 48 antibodies antibody NNS cord-286607-5i406twr 186 49 against against IN cord-286607-5i406twr 186 50 superantigens superantigen NNS cord-286607-5i406twr 186 51 of of IN cord-286607-5i406twr 186 52 Staphylococcus Staphylococcus NNP cord-286607-5i406twr 186 53 aureus aureus NN cord-286607-5i406twr 186 54 and and CC cord-286607-5i406twr 186 55 Streptococcus streptococcus NN cord-286607-5i406twr 186 56 pyogenes pyogene NNS cord-286607-5i406twr 186 57 in in IN cord-286607-5i406twr 186 58 Kawasaki Kawasaki NNP cord-286607-5i406twr 186 59 disease disease NN cord-286607-5i406twr 187 1 The the DT cord-286607-5i406twr 187 2 role role NN cord-286607-5i406twr 187 3 of of IN cord-286607-5i406twr 187 4 superantigens superantigen NNS cord-286607-5i406twr 187 5 of of IN cord-286607-5i406twr 187 6 group group NN cord-286607-5i406twr 187 7 A a DT cord-286607-5i406twr 187 8 Streptococcus Streptococcus NNP cord-286607-5i406twr 187 9 and and CC cord-286607-5i406twr 187 10 Staphylococcus Staphylococcus NNP cord-286607-5i406twr 187 11 aureus aureus NN cord-286607-5i406twr 187 12 in in IN cord-286607-5i406twr 187 13 Kawasaki Kawasaki NNP cord-286607-5i406twr 187 14 disease disease NN cord-286607-5i406twr 187 15 Detection detection NN cord-286607-5i406twr 187 16 of of IN cord-286607-5i406twr 187 17 multiple multiple JJ cord-286607-5i406twr 187 18 superantigen superantigen NN cord-286607-5i406twr 187 19 genes gene NNS cord-286607-5i406twr 187 20 in in IN cord-286607-5i406twr 187 21 stools stool NNS cord-286607-5i406twr 187 22 of of IN cord-286607-5i406twr 187 23 patients patient NNS cord-286607-5i406twr 187 24 with with IN cord-286607-5i406twr 187 25 Kawasaki Kawasaki NNP cord-286607-5i406twr 187 26 disease disease NN cord-286607-5i406twr 187 27 Mycoplasma Mycoplasma NNP cord-286607-5i406twr 187 28 pneumoniae pneumoniae NN cord-286607-5i406twr 187 29 infection infection NN cord-286607-5i406twr 187 30 in in IN cord-286607-5i406twr 187 31 patients patient NNS cord-286607-5i406twr 187 32 with with IN cord-286607-5i406twr 187 33 Kawasaki Kawasaki NNP cord-286607-5i406twr 187 34 disease disease NN cord-286607-5i406twr 187 35 Tropospheric Tropospheric NNP cord-286607-5i406twr 187 36 winds wind VBZ cord-286607-5i406twr 187 37 from from IN cord-286607-5i406twr 187 38 northeastern northeastern JJ cord-286607-5i406twr 187 39 China China NNP cord-286607-5i406twr 187 40 carry carry VBP cord-286607-5i406twr 187 41 the the DT cord-286607-5i406twr 187 42 etiologic etiologic JJ cord-286607-5i406twr 187 43 agent agent NN cord-286607-5i406twr 187 44 of of IN cord-286607-5i406twr 187 45 Kawasaki Kawasaki NNP cord-286607-5i406twr 187 46 disease disease NN cord-286607-5i406twr 187 47 from from IN cord-286607-5i406twr 187 48 its -PRON- PRP$ cord-286607-5i406twr 187 49 source source NN cord-286607-5i406twr 187 50 to to IN cord-286607-5i406twr 187 51 Japan Japan NNP cord-286607-5i406twr 187 52 Effects effect NNS cord-286607-5i406twr 187 53 of of IN cord-286607-5i406twr 187 54 natural natural JJ cord-286607-5i406twr 187 55 and and CC cord-286607-5i406twr 187 56 chemically chemically RB cord-286607-5i406twr 187 57 defined define VBN cord-286607-5i406twr 187 58 nutrients nutrient NNS cord-286607-5i406twr 187 59 on on IN cord-286607-5i406twr 187 60 Candida Candida NNP cord-286607-5i406twr 187 61 albicans albican NNS cord-286607-5i406twr 187 62 water water NN cord-286607-5i406twr 187 63 - - HYPH cord-286607-5i406twr 187 64 soluble soluble JJ cord-286607-5i406twr 187 65 fraction fraction NN cord-286607-5i406twr 187 66 ( ( -LRB- cord-286607-5i406twr 187 67 CAWS CAWS NNP cord-286607-5i406twr 187 68 ) ) -RRB- cord-286607-5i406twr 187 69 vasculitis vasculitis NN cord-286607-5i406twr 187 70 in in IN cord-286607-5i406twr 187 71 mice mouse NNS cord-286607-5i406twr 188 1 Neutrophil Neutrophil NNP cord-286607-5i406twr 188 2 activation activation NN cord-286607-5i406twr 188 3 and and CC cord-286607-5i406twr 188 4 arteritis arteritis NN cord-286607-5i406twr 188 5 induced induce VBN cord-286607-5i406twr 188 6 by by IN cord-286607-5i406twr 189 1 C. C. NNP cord-286607-5i406twr 189 2 albicans albican NNS cord-286607-5i406twr 189 3 water water NN cord-286607-5i406twr 189 4 - - HYPH cord-286607-5i406twr 189 5 soluble soluble JJ cord-286607-5i406twr 189 6 mannoprotein mannoprotein JJ cord-286607-5i406twr 189 7 - - HYPH cord-286607-5i406twr 189 8 beta beta NN cord-286607-5i406twr 189 9 - - HYPH cord-286607-5i406twr 189 10 glucan glucan NN cord-286607-5i406twr 189 11 complex complex NN cord-286607-5i406twr 189 12 ( ( -LRB- cord-286607-5i406twr 189 13 CAWS CAWS NNP cord-286607-5i406twr 189 14 ) ) -RRB- cord-286607-5i406twr 189 15 Induction induction NN cord-286607-5i406twr 189 16 of of IN cord-286607-5i406twr 189 17 coronary coronary JJ cord-286607-5i406twr 189 18 arteritis arteritis NN cord-286607-5i406twr 189 19 with with IN cord-286607-5i406twr 189 20 administration administration NN cord-286607-5i406twr 189 21 of of IN cord-286607-5i406twr 189 22 CAWS CAWS NNP cord-286607-5i406twr 190 1 ( ( -LRB- cord-286607-5i406twr 190 2 Candida candida NN cord-286607-5i406twr 190 3 albicans albican NNS cord-286607-5i406twr 190 4 water water NN cord-286607-5i406twr 190 5 - - HYPH cord-286607-5i406twr 190 6 soluble soluble JJ cord-286607-5i406twr 190 7 fraction fraction NN cord-286607-5i406twr 190 8 ) ) -RRB- cord-286607-5i406twr 191 1 depending depend VBG cord-286607-5i406twr 191 2 on on IN cord-286607-5i406twr 191 3 mouse mouse NN cord-286607-5i406twr 191 4 strains strain VBZ cord-286607-5i406twr 191 5 Kawasaki Kawasaki NNP cord-286607-5i406twr 191 6 disease disease NN cord-286607-5i406twr 191 7 may may MD cord-286607-5i406twr 191 8 be be VB cord-286607-5i406twr 191 9 a a DT cord-286607-5i406twr 191 10 hyperimmune hyperimmune JJ cord-286607-5i406twr 191 11 reaction reaction NN cord-286607-5i406twr 191 12 of of IN cord-286607-5i406twr 191 13 genetically genetically RB cord-286607-5i406twr 191 14 susceptible susceptible JJ cord-286607-5i406twr 191 15 children child NNS cord-286607-5i406twr 191 16 to to IN cord-286607-5i406twr 191 17 variants variant NNS cord-286607-5i406twr 191 18 of of IN cord-286607-5i406twr 191 19 normal normal JJ cord-286607-5i406twr 191 20 environmental environmental JJ cord-286607-5i406twr 191 21 flora flora NNS cord-286607-5i406twr 192 1 The the DT cord-286607-5i406twr 192 2 throat throat NN cord-286607-5i406twr 192 3 flora flora NNS cord-286607-5i406twr 192 4 and and CC cord-286607-5i406twr 192 5 its -PRON- PRP$ cord-286607-5i406twr 192 6 mitogenic mitogenic JJ cord-286607-5i406twr 192 7 activity activity NN cord-286607-5i406twr 192 8 in in IN cord-286607-5i406twr 192 9 patients patient NNS cord-286607-5i406twr 192 10 with with IN cord-286607-5i406twr 192 11 Kawasaki Kawasaki NNP cord-286607-5i406twr 192 12 disease disease NN cord-286607-5i406twr 192 13 Microbiologic Microbiologic NNP cord-286607-5i406twr 192 14 studies study NNS cord-286607-5i406twr 192 15 on on IN cord-286607-5i406twr 192 16 the the DT cord-286607-5i406twr 192 17 small small JJ cord-286607-5i406twr 192 18 intestine intestine NN cord-286607-5i406twr 192 19 in in IN cord-286607-5i406twr 192 20 Kawasaki Kawasaki NNP cord-286607-5i406twr 192 21 disease disease NN cord-286607-5i406twr 193 1 Immunohistochemical Immunohistochemical NNP cord-286607-5i406twr 193 2 studies study NNS cord-286607-5i406twr 193 3 on on IN cord-286607-5i406twr 193 4 small small JJ cord-286607-5i406twr 193 5 intestinal intestinal JJ cord-286607-5i406twr 193 6 mucosa mucosa NN cord-286607-5i406twr 193 7 in in IN cord-286607-5i406twr 193 8 Kawasakidisease Kawasakidisease NNP cord-286607-5i406twr 193 9 Kawasaki Kawasaki NNP cord-286607-5i406twr 193 10 disease disease NN cord-286607-5i406twr 193 11 and and CC cord-286607-5i406twr 193 12 the the DT cord-286607-5i406twr 193 13 pediatric pediatric JJ cord-286607-5i406twr 193 14 gastroenterologist gastroenterologist NN cord-286607-5i406twr 193 15 : : : cord-286607-5i406twr 193 16 a a DT cord-286607-5i406twr 193 17 diagnostic diagnostic JJ cord-286607-5i406twr 193 18 challenge challenge NN cord-286607-5i406twr 193 19 Characteristic characteristic JJ cord-286607-5i406twr 193 20 role role NN cord-286607-5i406twr 193 21 of of IN cord-286607-5i406twr 193 22 intestinal intestinal JJ cord-286607-5i406twr 193 23 microflora microflora NN cord-286607-5i406twr 193 24 in in IN cord-286607-5i406twr 193 25 Kawasaki Kawasaki NNP cord-286607-5i406twr 193 26 disease disease NN cord-286607-5i406twr 194 1 The the DT cord-286607-5i406twr 194 2 starting starting NN cord-286607-5i406twr 194 3 lineup lineup NN cord-286607-5i406twr 194 4 : : : cord-286607-5i406twr 195 1 key key JJ cord-286607-5i406twr 195 2 microbial microbial JJ cord-286607-5i406twr 195 3 players player NNS cord-286607-5i406twr 195 4 in in IN cord-286607-5i406twr 195 5 intestinal intestinal JJ cord-286607-5i406twr 195 6 immunity immunity NN cord-286607-5i406twr 195 7 and and CC cord-286607-5i406twr 195 8 homeostasis homeostasis NN cord-286607-5i406twr 195 9 Anti anti JJ cord-286607-5i406twr 195 10 - - JJ cord-286607-5i406twr 195 11 inflammatory inflammatory JJ cord-286607-5i406twr 195 12 capacity capacity NN cord-286607-5i406twr 195 13 of of IN cord-286607-5i406twr 195 14 selected select VBN cord-286607-5i406twr 195 15 lactobacilli lactobacillus NNS cord-286607-5i406twr 195 16 in in IN cord-286607-5i406twr 195 17 experimental experimental JJ cord-286607-5i406twr 195 18 colitis colitis NN cord-286607-5i406twr 195 19 is be VBZ cord-286607-5i406twr 195 20 driven drive VBN cord-286607-5i406twr 195 21 by by IN cord-286607-5i406twr 195 22 NOD2-mediated nod2-mediated JJ cord-286607-5i406twr 195 23 recognition recognition NN cord-286607-5i406twr 195 24 of of IN cord-286607-5i406twr 195 25 a a DT cord-286607-5i406twr 195 26 specific specific JJ cord-286607-5i406twr 195 27 peptidoglycan peptidoglycan NN cord-286607-5i406twr 195 28 - - HYPH cord-286607-5i406twr 195 29 derived derive VBN cord-286607-5i406twr 195 30 muropeptide muropeptide NNP cord-286607-5i406twr 195 31 Anti anti JJ cord-286607-5i406twr 195 32 - - JJ cord-286607-5i406twr 195 33 inflammatory inflammatory JJ cord-286607-5i406twr 195 34 effect effect NN cord-286607-5i406twr 195 35 of of IN cord-286607-5i406twr 195 36 Lactobacillus lactobacillus NN cord-286607-5i406twr 195 37 casei casei NN cord-286607-5i406twr 195 38 on on IN cord-286607-5i406twr 195 39 Shigellainfected Shigellainfected NNP cord-286607-5i406twr 195 40 human human JJ cord-286607-5i406twr 195 41 intestinal intestinal JJ cord-286607-5i406twr 195 42 epithelial epithelial JJ cord-286607-5i406twr 195 43 cells cell NNS cord-286607-5i406twr 195 44 Heat heat VBP cord-286607-5i406twr 195 45 shock shock NN cord-286607-5i406twr 195 46 proteins protein NNS cord-286607-5i406twr 195 47 and and CC cord-286607-5i406twr 195 48 superantigenic superantigenic JJ cord-286607-5i406twr 195 49 properties property NNS cord-286607-5i406twr 195 50 of of IN cord-286607-5i406twr 195 51 bacteria bacteria NNS cord-286607-5i406twr 195 52 from from IN cord-286607-5i406twr 195 53 the the DT cord-286607-5i406twr 195 54 gastrointestinal gastrointestinal JJ cord-286607-5i406twr 195 55 tract tract NN cord-286607-5i406twr 195 56 of of IN cord-286607-5i406twr 195 57 patients patient NNS cord-286607-5i406twr 195 58 with with IN cord-286607-5i406twr 195 59 Kawasaki Kawasaki NNP cord-286607-5i406twr 195 60 disease disease NN cord-286607-5i406twr 195 61 Characterization characterization NN cord-286607-5i406twr 195 62 of of IN cord-286607-5i406twr 195 63 the the DT cord-286607-5i406twr 195 64 gut gut NN cord-286607-5i406twr 195 65 microbiota microbiota NN cord-286607-5i406twr 195 66 of of IN cord-286607-5i406twr 195 67 Kawasaki Kawasaki NNP cord-286607-5i406twr 195 68 disease disease NN cord-286607-5i406twr 195 69 patients patient NNS cord-286607-5i406twr 195 70 by by IN cord-286607-5i406twr 195 71 metagenomic metagenomic NNP cord-286607-5i406twr 195 72 analysis analysis NNP cord-286607-5i406twr 196 1 Altered altered JJ cord-286607-5i406twr 196 2 mucosal mucosal JJ cord-286607-5i406twr 196 3 microbiome microbiome NN cord-286607-5i406twr 196 4 diversity diversity NN cord-286607-5i406twr 196 5 and and CC cord-286607-5i406twr 196 6 disease disease NN cord-286607-5i406twr 196 7 severity severity NN cord-286607-5i406twr 196 8 in in IN cord-286607-5i406twr 196 9 Sjögren Sjögren NNP cord-286607-5i406twr 196 10 syndrome syndrome NN cord-286607-5i406twr 196 11 Alterations alteration NNS cord-286607-5i406twr 196 12 of of IN cord-286607-5i406twr 196 13 the the DT cord-286607-5i406twr 196 14 human human JJ cord-286607-5i406twr 196 15 gut gut NN cord-286607-5i406twr 196 16 microbiome microbiome NN cord-286607-5i406twr 196 17 in in IN cord-286607-5i406twr 196 18 liver liver NN cord-286607-5i406twr 196 19 cirrhosis cirrhosis NN cord-286607-5i406twr 196 20 Eubiosis Eubiosis NNP cord-286607-5i406twr 196 21 and and CC cord-286607-5i406twr 196 22 dysbiosis dysbiosis NN cord-286607-5i406twr 196 23 : : : cord-286607-5i406twr 196 24 the the DT cord-286607-5i406twr 196 25 two two CD cord-286607-5i406twr 196 26 sides side NNS cord-286607-5i406twr 196 27 of of IN cord-286607-5i406twr 196 28 the the DT cord-286607-5i406twr 196 29 microbiota microbiota NN