id	sid	tid	token	lemma	pos
cord-287853-cob7ur35	1	1	key	key	NN
cord-287853-cob7ur35	1	2	:	:	:
cord-287853-cob7ur35	2	1	cord-287853-cob7ur35	cord-287853-cob7ur35	NNP
cord-287853-cob7ur35	2	2	authors	author	NNS
cord-287853-cob7ur35	2	3	:	:	:
cord-287853-cob7ur35	2	4	Sharma	Sharma	NNP
cord-287853-cob7ur35	2	5	,	,	,
cord-287853-cob7ur35	2	6	Vaneet	Vaneet	NNP
cord-287853-cob7ur35	2	7	Kumar	Kumar	NNP
cord-287853-cob7ur35	2	8	;	;	:
cord-287853-cob7ur35	2	9	Sharma	Sharma	NNP
cord-287853-cob7ur35	2	10	,	,	,
cord-287853-cob7ur35	2	11	Ity	Ity	NNP
cord-287853-cob7ur35	2	12	;	;	:
cord-287853-cob7ur35	2	13	Glick	Glick	NNP
cord-287853-cob7ur35	2	14	,	,	,
cord-287853-cob7ur35	2	15	James	James	NNP
cord-287853-cob7ur35	2	16	title	title	NN
cord-287853-cob7ur35	2	17	:	:	:
cord-287853-cob7ur35	2	18	The	the	DT
cord-287853-cob7ur35	2	19	expanding	expand	VBG
cord-287853-cob7ur35	2	20	role	role	NN
cord-287853-cob7ur35	2	21	of	of	IN
cord-287853-cob7ur35	2	22	mass	mass	NN
cord-287853-cob7ur35	2	23	spectrometry	spectrometry	NN
cord-287853-cob7ur35	2	24	in	in	IN
cord-287853-cob7ur35	2	25	the	the	DT
cord-287853-cob7ur35	2	26	field	field	NN
cord-287853-cob7ur35	2	27	of	of	IN
cord-287853-cob7ur35	2	28	vaccine	vaccine	NN
cord-287853-cob7ur35	2	29	development	development	NN
cord-287853-cob7ur35	2	30	date	date	NN
cord-287853-cob7ur35	2	31	:	:	:
cord-287853-cob7ur35	2	32	2018	2018	CD
cord-287853-cob7ur35	2	33	-	-	HYPH
cord-287853-cob7ur35	2	34	05	05	CD
cord-287853-cob7ur35	2	35	-	-	HYPH
cord-287853-cob7ur35	2	36	31	31	CD
cord-287853-cob7ur35	2	37	journal	journal	NN
cord-287853-cob7ur35	2	38	:	:	:
cord-287853-cob7ur35	3	1	Mass	Mass	NNP
cord-287853-cob7ur35	3	2	Spectrom	Spectrom	NNP
cord-287853-cob7ur35	3	3	Rev	Rev	NNP
cord-287853-cob7ur35	3	4	DOI	DOI	NNP
cord-287853-cob7ur35	3	5	:	:	:
cord-287853-cob7ur35	3	6	10.1002	10.1002	CD
cord-287853-cob7ur35	3	7	/	/	SYM
cord-287853-cob7ur35	3	8	mas.21571	mas.21571	NN
cord-287853-cob7ur35	3	9	sha	sha	NNP
cord-287853-cob7ur35	3	10	:	:	:
cord-287853-cob7ur35	3	11	b4e276ce333eefee623e9d425f5c538c64b567cc	b4e276ce333eefee623e9d425f5c538c64b567cc	NNP
cord-287853-cob7ur35	3	12	doc_id	doc_id	CD
cord-287853-cob7ur35	3	13	:	:	:
cord-287853-cob7ur35	3	14	287853	287853	CD
cord-287853-cob7ur35	3	15	cord_uid	cord_uid	NNS
cord-287853-cob7ur35	3	16	:	:	:
cord-287853-cob7ur35	4	1	cob7ur35	cob7ur35	NNP
cord-287853-cob7ur35	5	1	Biological	biological	JJ
cord-287853-cob7ur35	5	2	mass	mass	NN
cord-287853-cob7ur35	5	3	spectrometry	spectrometry	NN
cord-287853-cob7ur35	5	4	has	have	VBZ
cord-287853-cob7ur35	5	5	evolved	evolve	VBN
cord-287853-cob7ur35	5	6	as	as	IN
cord-287853-cob7ur35	5	7	a	a	DT
cord-287853-cob7ur35	5	8	core	core	NN
cord-287853-cob7ur35	5	9	analytical	analytical	JJ
cord-287853-cob7ur35	5	10	technology	technology	NN
cord-287853-cob7ur35	5	11	in	in	IN
cord-287853-cob7ur35	5	12	the	the	DT
cord-287853-cob7ur35	5	13	last	last	JJ
cord-287853-cob7ur35	5	14	decade	decade	NN
cord-287853-cob7ur35	5	15	mainly	mainly	RB
cord-287853-cob7ur35	5	16	because	because	IN
cord-287853-cob7ur35	5	17	of	of	IN
cord-287853-cob7ur35	5	18	its	-PRON-	PRP$
cord-287853-cob7ur35	5	19	unparalleled	unparalleled	JJ
cord-287853-cob7ur35	5	20	ability	ability	NN
cord-287853-cob7ur35	5	21	to	to	TO
cord-287853-cob7ur35	5	22	perform	perform	VB
cord-287853-cob7ur35	5	23	qualitative	qualitative	JJ
cord-287853-cob7ur35	5	24	as	as	RB
cord-287853-cob7ur35	5	25	well	well	RB
cord-287853-cob7ur35	5	26	as	as	IN
cord-287853-cob7ur35	5	27	quantitative	quantitative	JJ
cord-287853-cob7ur35	5	28	profiling	profiling	NN
cord-287853-cob7ur35	5	29	of	of	IN
cord-287853-cob7ur35	5	30	enormously	enormously	RB
cord-287853-cob7ur35	5	31	complex	complex	JJ
cord-287853-cob7ur35	5	32	biological	biological	JJ
cord-287853-cob7ur35	5	33	samples	sample	NNS
cord-287853-cob7ur35	5	34	with	with	IN
cord-287853-cob7ur35	5	35	high	high	JJ
cord-287853-cob7ur35	5	36	mass	mass	NN
cord-287853-cob7ur35	5	37	accuracy	accuracy	NN
cord-287853-cob7ur35	5	38	,	,	,
cord-287853-cob7ur35	5	39	sensitivity	sensitivity	NN
cord-287853-cob7ur35	5	40	,	,	,
cord-287853-cob7ur35	5	41	selectivity	selectivity	NN
cord-287853-cob7ur35	5	42	and	and	CC
cord-287853-cob7ur35	5	43	specificity	specificity	NN
cord-287853-cob7ur35	5	44	.	.	.
cord-287853-cob7ur35	6	1	Mass	mass	JJ
cord-287853-cob7ur35	6	2	spectrometry‐based	spectrometry‐based	JJ
cord-287853-cob7ur35	6	3	techniques	technique	NNS
cord-287853-cob7ur35	6	4	are	be	VBP
cord-287853-cob7ur35	6	5	also	also	RB
cord-287853-cob7ur35	6	6	routinely	routinely	RB
cord-287853-cob7ur35	6	7	used	use	VBN
cord-287853-cob7ur35	6	8	to	to	TO
cord-287853-cob7ur35	6	9	assess	assess	VB
cord-287853-cob7ur35	6	10	glycosylation	glycosylation	NN
cord-287853-cob7ur35	6	11	and	and	CC
cord-287853-cob7ur35	6	12	other	other	JJ
cord-287853-cob7ur35	6	13	post‐translational	post‐translational	JJ
cord-287853-cob7ur35	6	14	modifications	modification	NNS
cord-287853-cob7ur35	6	15	,	,	,
cord-287853-cob7ur35	6	16	disulfide	disulfide	JJ
cord-287853-cob7ur35	6	17	bond	bond	NN
cord-287853-cob7ur35	6	18	linkage	linkage	NN
cord-287853-cob7ur35	6	19	,	,	,
cord-287853-cob7ur35	6	20	and	and	CC
cord-287853-cob7ur35	6	21	scrambling	scramble	VBG
cord-287853-cob7ur35	6	22	as	as	RB
cord-287853-cob7ur35	6	23	well	well	RB
cord-287853-cob7ur35	6	24	as	as	IN
cord-287853-cob7ur35	6	25	for	for	IN
cord-287853-cob7ur35	6	26	the	the	DT
cord-287853-cob7ur35	6	27	detection	detection	NN
cord-287853-cob7ur35	6	28	of	of	IN
cord-287853-cob7ur35	6	29	host	host	NN
cord-287853-cob7ur35	6	30	cell	cell	NN
cord-287853-cob7ur35	6	31	protein	protein	NN
cord-287853-cob7ur35	6	32	contaminants	contaminant	NNS
cord-287853-cob7ur35	6	33	in	in	IN
cord-287853-cob7ur35	6	34	the	the	DT
cord-287853-cob7ur35	6	35	field	field	NN
cord-287853-cob7ur35	6	36	of	of	IN
cord-287853-cob7ur35	6	37	biopharmaceuticals	biopharmaceutical	NNS
cord-287853-cob7ur35	6	38	.	.	.
cord-287853-cob7ur35	7	1	The	the	DT
cord-287853-cob7ur35	7	2	role	role	NN
cord-287853-cob7ur35	7	3	of	of	IN
cord-287853-cob7ur35	7	4	mass	mass	JJ
cord-287853-cob7ur35	7	5	spectrometry	spectrometry	NN
cord-287853-cob7ur35	7	6	in	in	IN
cord-287853-cob7ur35	7	7	vaccine	vaccine	NN
cord-287853-cob7ur35	7	8	development	development	NN
cord-287853-cob7ur35	7	9	has	have	VBZ
cord-287853-cob7ur35	7	10	been	be	VBN
cord-287853-cob7ur35	7	11	very	very	RB
cord-287853-cob7ur35	7	12	limited	limited	JJ
cord-287853-cob7ur35	7	13	but	but	CC
cord-287853-cob7ur35	7	14	is	be	VBZ
cord-287853-cob7ur35	7	15	now	now	RB
cord-287853-cob7ur35	7	16	expanding	expand	VBG
cord-287853-cob7ur35	7	17	as	as	IN
cord-287853-cob7ur35	7	18	the	the	DT
cord-287853-cob7ur35	7	19	landscape	landscape	NN
cord-287853-cob7ur35	7	20	of	of	IN
cord-287853-cob7ur35	7	21	global	global	JJ
cord-287853-cob7ur35	7	22	vaccine	vaccine	NN
cord-287853-cob7ur35	7	23	development	development	NN
cord-287853-cob7ur35	7	24	is	be	VBZ
cord-287853-cob7ur35	7	25	shifting	shift	VBG
cord-287853-cob7ur35	7	26	towards	towards	IN
cord-287853-cob7ur35	7	27	the	the	DT
cord-287853-cob7ur35	7	28	development	development	NN
cord-287853-cob7ur35	7	29	of	of	IN
cord-287853-cob7ur35	7	30	recombinant	recombinant	JJ
cord-287853-cob7ur35	7	31	vaccines	vaccine	NNS
cord-287853-cob7ur35	7	32	.	.	.
cord-287853-cob7ur35	8	1	In	in	IN
cord-287853-cob7ur35	8	2	this	this	DT
cord-287853-cob7ur35	8	3	review	review	NN
cord-287853-cob7ur35	8	4	,	,	,
cord-287853-cob7ur35	8	5	the	the	DT
cord-287853-cob7ur35	8	6	role	role	NN
cord-287853-cob7ur35	8	7	of	of	IN
cord-287853-cob7ur35	8	8	mass	mass	JJ
cord-287853-cob7ur35	8	9	spectrometry	spectrometry	NN
cord-287853-cob7ur35	8	10	in	in	IN
cord-287853-cob7ur35	8	11	vaccine	vaccine	NN
cord-287853-cob7ur35	8	12	development	development	NN
cord-287853-cob7ur35	8	13	is	be	VBZ
cord-287853-cob7ur35	8	14	presented	present	VBN
cord-287853-cob7ur35	8	15	,	,	,
cord-287853-cob7ur35	8	16	some	some	DT
cord-287853-cob7ur35	8	17	of	of	IN
cord-287853-cob7ur35	8	18	the	the	DT
cord-287853-cob7ur35	8	19	ongoing	ongoing	JJ
cord-287853-cob7ur35	8	20	efforts	effort	NNS
cord-287853-cob7ur35	8	21	to	to	TO
cord-287853-cob7ur35	8	22	develop	develop	VB
cord-287853-cob7ur35	8	23	vaccines	vaccine	NNS
cord-287853-cob7ur35	8	24	for	for	IN
cord-287853-cob7ur35	8	25	diseases	disease	NNS
cord-287853-cob7ur35	8	26	with	with	IN
cord-287853-cob7ur35	8	27	global	global	JJ
cord-287853-cob7ur35	8	28	unmet	unmet	JJ
cord-287853-cob7ur35	8	29	medical	medical	JJ
cord-287853-cob7ur35	8	30	need	need	NN
cord-287853-cob7ur35	8	31	are	be	VBP
cord-287853-cob7ur35	8	32	discussed	discuss	VBN
cord-287853-cob7ur35	8	33	and	and	CC
cord-287853-cob7ur35	8	34	the	the	DT
cord-287853-cob7ur35	8	35	regulatory	regulatory	JJ
cord-287853-cob7ur35	8	36	challenges	challenge	NNS
cord-287853-cob7ur35	8	37	of	of	IN
cord-287853-cob7ur35	8	38	implementing	implement	VBG
cord-287853-cob7ur35	8	39	mass	mass	NN
cord-287853-cob7ur35	8	40	spectrometry	spectrometry	NN
cord-287853-cob7ur35	8	41	techniques	technique	NNS
cord-287853-cob7ur35	8	42	in	in	IN
cord-287853-cob7ur35	8	43	a	a	DT
cord-287853-cob7ur35	8	44	quality	quality	NN
cord-287853-cob7ur35	8	45	control	control	NN
cord-287853-cob7ur35	8	46	laboratory	laboratory	NN
cord-287853-cob7ur35	8	47	setting	setting	NN
cord-287853-cob7ur35	8	48	are	be	VBP
cord-287853-cob7ur35	8	49	highlighted	highlight	VBN
cord-287853-cob7ur35	8	50	.	.	.
cord-287853-cob7ur35	9	1	As	as	IN
cord-287853-cob7ur35	9	2	the	the	DT
cord-287853-cob7ur35	9	3	target	target	NN
cord-287853-cob7ur35	9	4	populations	population	NNS
cord-287853-cob7ur35	9	5	for	for	IN
cord-287853-cob7ur35	9	6	the	the	DT
cord-287853-cob7ur35	9	7	vaccines	vaccine	NNS
cord-287853-cob7ur35	9	8	are	be	VBP
cord-287853-cob7ur35	9	9	healthy	healthy	JJ
cord-287853-cob7ur35	9	10	individuals	individual	NNS
cord-287853-cob7ur35	9	11	,	,	,
cord-287853-cob7ur35	9	12	pregnant	pregnant	JJ
cord-287853-cob7ur35	9	13	women	woman	NNS
cord-287853-cob7ur35	9	14	,	,	,
cord-287853-cob7ur35	9	15	or	or	CC
cord-287853-cob7ur35	9	16	infants	infant	NNS
cord-287853-cob7ur35	9	17	,	,	,
cord-287853-cob7ur35	9	18	vaccine	vaccine	NN
cord-287853-cob7ur35	9	19	safety	safety	NN
cord-287853-cob7ur35	9	20	is	be	VBZ
cord-287853-cob7ur35	9	21	of	of	IN
cord-287853-cob7ur35	9	22	paramount	paramount	JJ
cord-287853-cob7ur35	9	23	importance	importance	NN
cord-287853-cob7ur35	9	24	.	.	.
cord-287853-cob7ur35	10	1	Appropriately	appropriately	RB
cord-287853-cob7ur35	10	2	,	,	,
cord-287853-cob7ur35	10	3	the	the	DT
cord-287853-cob7ur35	10	4	vaccine	vaccine	NN
cord-287853-cob7ur35	10	5	landscape	landscape	NN
cord-287853-cob7ur35	10	6	is	be	VBZ
cord-287853-cob7ur35	10	7	changing	change	VBG
cord-287853-cob7ur35	10	8	from	from	IN
cord-287853-cob7ur35	10	9	traditional	traditional	JJ
cord-287853-cob7ur35	10	10	vaccine	vaccine	NN
cord-287853-cob7ur35	10	11	approaches	approach	VBZ
cord-287853-cob7ur35	10	12	to	to	TO
cord-287853-cob7ur35	10	13	cost	cost	VB
cord-287853-cob7ur35	10	14	-	-	HYPH
cord-287853-cob7ur35	10	15	effective	effective	JJ
cord-287853-cob7ur35	10	16	,	,	,
cord-287853-cob7ur35	10	17	highly	highly	RB
cord-287853-cob7ur35	10	18	scalable	scalable	JJ
cord-287853-cob7ur35	10	19	,	,	,
cord-287853-cob7ur35	10	20	and	and	CC
cord-287853-cob7ur35	10	21	safe	safe	JJ
cord-287853-cob7ur35	10	22	recombinant	recombinant	JJ
cord-287853-cob7ur35	10	23	vaccines	vaccine	NNS
cord-287853-cob7ur35	10	24	.	.	.
cord-287853-cob7ur35	11	1	9	9	CD
cord-287853-cob7ur35	11	2	,	,	,
cord-287853-cob7ur35	11	3	10	10	CD
cord-287853-cob7ur35	11	4	Using	use	VBG
cord-287853-cob7ur35	11	5	recombinant	recombinant	JJ
cord-287853-cob7ur35	11	6	DNA	dna	NN
cord-287853-cob7ur35	11	7	technology	technology	NN
cord-287853-cob7ur35	11	8	,	,	,
cord-287853-cob7ur35	11	9	antigens	antigen	NNS
cord-287853-cob7ur35	11	10	are	be	VBP
cord-287853-cob7ur35	11	11	expressed	express	VBN
cord-287853-cob7ur35	11	12	in	in	IN
cord-287853-cob7ur35	11	13	yeast	yeast	NN
cord-287853-cob7ur35	11	14	,	,	,
cord-287853-cob7ur35	11	15	Escherichia	Escherichia	NNP
cord-287853-cob7ur35	11	16	coli	coli	NNS
cord-287853-cob7ur35	11	17	,	,	,
cord-287853-cob7ur35	11	18	baculovirus	baculovirus	NNP
cord-287853-cob7ur35	11	19	expression	expression	NN
cord-287853-cob7ur35	11	20	vector	vector	NN
cord-287853-cob7ur35	11	21	system	system	NN
cord-287853-cob7ur35	11	22	(	(	-LRB-
cord-287853-cob7ur35	11	23	BEVS	BEVS	NNP
cord-287853-cob7ur35	11	24	)	)	-RRB-
cord-287853-cob7ur35	11	25	,	,	,
cord-287853-cob7ur35	11	26	or	or	CC
cord-287853-cob7ur35	11	27	mammalian	mammalian	JJ
cord-287853-cob7ur35	11	28	cell	cell	NN
cord-287853-cob7ur35	11	29	lines	line	NNS
cord-287853-cob7ur35	11	30	.	.	.
cord-287853-cob7ur35	12	1	[	[	-LRB-
cord-287853-cob7ur35	12	2	11	11	CD
cord-287853-cob7ur35	12	3	]	]	-RRB-
cord-287853-cob7ur35	12	4	[	[	-LRB-
cord-287853-cob7ur35	12	5	12	12	CD
cord-287853-cob7ur35	12	6	]	]	-RRB-
cord-287853-cob7ur35	12	7	[	[	-LRB-
cord-287853-cob7ur35	12	8	13	13	CD
cord-287853-cob7ur35	12	9	]	]	-RRB-
cord-287853-cob7ur35	13	1	Recombinant	recombinant	JJ
cord-287853-cob7ur35	13	2	antigens	antigen	NNS
cord-287853-cob7ur35	13	3	are	be	VBP
cord-287853-cob7ur35	13	4	engineered	engineer	VBN
cord-287853-cob7ur35	13	5	to	to	TO
cord-287853-cob7ur35	13	6	mimic	mimic	VB
cord-287853-cob7ur35	13	7	the	the	DT
cord-287853-cob7ur35	13	8	first	first	JJ
cord-287853-cob7ur35	13	9	step	step	NN
cord-287853-cob7ur35	13	10	of	of	IN
cord-287853-cob7ur35	13	11	virus	virus	NN
cord-287853-cob7ur35	13	12	attachment	attachment	NN
cord-287853-cob7ur35	13	13	to	to	IN
cord-287853-cob7ur35	13	14	the	the	DT
cord-287853-cob7ur35	13	15	cell	cell	NN
cord-287853-cob7ur35	13	16	surface	surface	NN
cord-287853-cob7ur35	13	17	which	which	WDT
cord-287853-cob7ur35	13	18	is	be	VBZ
cord-287853-cob7ur35	13	19	mediated	mediate	VBN
cord-287853-cob7ur35	13	20	by	by	IN
cord-287853-cob7ur35	13	21	specific	specific	JJ
cord-287853-cob7ur35	13	22	glycoproteins	glycoprotein	NNS
cord-287853-cob7ur35	13	23	.	.	.
cord-287853-cob7ur35	14	1	The	the	DT
cord-287853-cob7ur35	14	2	expressed	express	VBN
cord-287853-cob7ur35	14	3	recombinant	recombinant	JJ
cord-287853-cob7ur35	14	4	antigens	antigen	NNS
cord-287853-cob7ur35	14	5	undergo	undergo	VBP
cord-287853-cob7ur35	14	6	multiple	multiple	JJ
cord-287853-cob7ur35	14	7	purification	purification	NN
cord-287853-cob7ur35	14	8	cycles	cycle	NNS
cord-287853-cob7ur35	14	9	to	to	TO
cord-287853-cob7ur35	14	10	produce	produce	VB
cord-287853-cob7ur35	14	11	highly	highly	RB
cord-287853-cob7ur35	14	12	purified	purify	VBN
cord-287853-cob7ur35	14	13	vaccines	vaccine	NNS
cord-287853-cob7ur35	14	14	.	.	.
cord-287853-cob7ur35	15	1	14	14	CD
cord-287853-cob7ur35	15	2	,	,	,
cord-287853-cob7ur35	15	3	15	15	CD
cord-287853-cob7ur35	16	1	In	in	IN
cord-287853-cob7ur35	16	2	order	order	NN
cord-287853-cob7ur35	16	3	for	for	IN
cord-287853-cob7ur35	16	4	recombinant	recombinant	JJ
cord-287853-cob7ur35	16	5	vaccines	vaccine	NNS
cord-287853-cob7ur35	16	6	to	to	TO
cord-287853-cob7ur35	16	7	be	be	VB
cord-287853-cob7ur35	16	8	acceptable	acceptable	JJ
cord-287853-cob7ur35	16	9	to	to	IN
cord-287853-cob7ur35	16	10	regulatory	regulatory	JJ
cord-287853-cob7ur35	16	11	authorities	authority	NNS
cord-287853-cob7ur35	16	12	,	,	,
cord-287853-cob7ur35	16	13	in	in	IN
cord-287853-cob7ur35	16	14	-	-	HYPH
cord-287853-cob7ur35	16	15	depth	depth	NN
cord-287853-cob7ur35	16	16	analytical	analytical	JJ
cord-287853-cob7ur35	16	17	characterization	characterization	NN
cord-287853-cob7ur35	16	18	needs	need	VBZ
cord-287853-cob7ur35	16	19	to	to	TO
cord-287853-cob7ur35	16	20	be	be	VB
cord-287853-cob7ur35	16	21	performed	perform	VBN
cord-287853-cob7ur35	16	22	In	in	IN
cord-287853-cob7ur35	16	23	this	this	DT
cord-287853-cob7ur35	16	24	review	review	NN
cord-287853-cob7ur35	16	25	,	,	,
cord-287853-cob7ur35	16	26	we	-PRON-	PRP
cord-287853-cob7ur35	16	27	focus	focus	VBP
cord-287853-cob7ur35	16	28	on	on	IN
cord-287853-cob7ur35	16	29	the	the	DT
cord-287853-cob7ur35	16	30	expanding	expand	VBG
cord-287853-cob7ur35	16	31	role	role	NN
cord-287853-cob7ur35	16	32	of	of	IN
cord-287853-cob7ur35	16	33	mass	mass	JJ
cord-287853-cob7ur35	16	34	spectrometry	spectrometry	NN
cord-287853-cob7ur35	16	35	in	in	IN
cord-287853-cob7ur35	16	36	vaccine	vaccine	NN
cord-287853-cob7ur35	16	37	development	development	NN
cord-287853-cob7ur35	16	38	,	,	,
cord-287853-cob7ur35	16	39	irrespective	irrespective	RB
cord-287853-cob7ur35	16	40	of	of	IN
cord-287853-cob7ur35	16	41	the	the	DT
cord-287853-cob7ur35	16	42	route	route	NN
cord-287853-cob7ur35	16	43	of	of	IN
cord-287853-cob7ur35	16	44	production	production	NN
cord-287853-cob7ur35	16	45	.	.	.
cord-287853-cob7ur35	17	1	We	-PRON-	PRP
cord-287853-cob7ur35	17	2	also	also	RB
cord-287853-cob7ur35	17	3	highlight	highlight	VBP
cord-287853-cob7ur35	17	4	the	the	DT
cord-287853-cob7ur35	17	5	regulatory	regulatory	JJ
cord-287853-cob7ur35	17	6	challenges	challenge	NNS
cord-287853-cob7ur35	17	7	and	and	CC
cord-287853-cob7ur35	17	8	limitations	limitation	NNS
cord-287853-cob7ur35	17	9	of	of	IN
cord-287853-cob7ur35	17	10	mass	mass	NN
cord-287853-cob7ur35	17	11	spectrometry	spectrometry	NN
cord-287853-cob7ur35	17	12	-	-	HYPH
cord-287853-cob7ur35	17	13	based	base	VBN
cord-287853-cob7ur35	17	14	techniques	technique	NNS
cord-287853-cob7ur35	17	15	which	which	WDT
cord-287853-cob7ur35	17	16	constrain	constrain	VBP
cord-287853-cob7ur35	17	17	its	-PRON-	PRP$
cord-287853-cob7ur35	17	18	further	further	JJ
cord-287853-cob7ur35	17	19	implementation	implementation	NN
cord-287853-cob7ur35	17	20	as	as	IN
cord-287853-cob7ur35	17	21	a	a	DT
cord-287853-cob7ur35	17	22	quality	quality	NN
cord-287853-cob7ur35	17	23	control	control	NN
cord-287853-cob7ur35	17	24	batch	batch	NN
cord-287853-cob7ur35	17	25	release	release	NN
cord-287853-cob7ur35	17	26	assay	assay	NN
cord-287853-cob7ur35	17	27	in	in	IN
cord-287853-cob7ur35	17	28	cGMP	cGMP	NNP
cord-287853-cob7ur35	17	29	manufacturing	manufacturing	NN
cord-287853-cob7ur35	17	30	.	.	.
cord-287853-cob7ur35	18	1	The	the	DT
cord-287853-cob7ur35	18	2	role	role	NN
cord-287853-cob7ur35	18	3	of	of	IN
cord-287853-cob7ur35	18	4	mass	mass	NN
cord-287853-cob7ur35	18	5	spectrometry	spectrometry	NN
cord-287853-cob7ur35	18	6	(	(	-LRB-
cord-287853-cob7ur35	18	7	Alternatively	alternatively	RB
cord-287853-cob7ur35	18	8	,	,	,
cord-287853-cob7ur35	18	9	an	an	DT
cord-287853-cob7ur35	18	10	O	o	NN
cord-287853-cob7ur35	18	11	-	-	HYPH
cord-287853-cob7ur35	18	12	linked	link	VBN
cord-287853-cob7ur35	18	13	glycan	glycan	NN
cord-287853-cob7ur35	18	14	can	can	MD
cord-287853-cob7ur35	18	15	be	be	VB
cord-287853-cob7ur35	18	16	formed	form	VBN
cord-287853-cob7ur35	18	17	by	by	IN
cord-287853-cob7ur35	18	18	linking	link	VBG
cord-287853-cob7ur35	18	19	the	the	DT
cord-287853-cob7ur35	18	20	oligosaccharide	oligosaccharide	NN
cord-287853-cob7ur35	18	21	to	to	IN
cord-287853-cob7ur35	18	22	a	a	DT
cord-287853-cob7ur35	18	23	serine	serine	NN
cord-287853-cob7ur35	18	24	or	or	CC
cord-287853-cob7ur35	18	25	threonine	threonine	NN
cord-287853-cob7ur35	18	26	residue	residue	NN
cord-287853-cob7ur35	18	27	.	.	.
cord-287853-cob7ur35	19	1	Glycosylation	glycosylation	NN
cord-287853-cob7ur35	19	2	play	play	VBP
cord-287853-cob7ur35	19	3	a	a	DT
cord-287853-cob7ur35	19	4	fundamental	fundamental	JJ
cord-287853-cob7ur35	19	5	role	role	NN
cord-287853-cob7ur35	19	6	in	in	IN
cord-287853-cob7ur35	19	7	antigen	antigen	NN
cord-287853-cob7ur35	19	8	conformation	conformation	NN
cord-287853-cob7ur35	19	9	,	,	,
cord-287853-cob7ur35	19	10	folding	folding	NN
cord-287853-cob7ur35	19	11	,	,	,
cord-287853-cob7ur35	19	12	stability	stability	NN
cord-287853-cob7ur35	19	13	,	,	,
cord-287853-cob7ur35	19	14	solubility	solubility	NN
cord-287853-cob7ur35	19	15	,	,	,
cord-287853-cob7ur35	19	16	and	and	CC
cord-287853-cob7ur35	19	17	importantly	importantly	RB
cord-287853-cob7ur35	19	18	,	,	,
cord-287853-cob7ur35	19	19	immune	immune	JJ
cord-287853-cob7ur35	19	20	response	response	NN
cord-287853-cob7ur35	19	21	.	.	.
cord-287853-cob7ur35	20	1	16	16	CD
cord-287853-cob7ur35	20	2	,	,	,
cord-287853-cob7ur35	20	3	17	17	CD
cord-287853-cob7ur35	20	4	Plants	plant	NNS
cord-287853-cob7ur35	20	5	,	,	,
cord-287853-cob7ur35	20	6	yeasts	yeast	NNS
cord-287853-cob7ur35	20	7	,	,	,
cord-287853-cob7ur35	20	8	and	and	CC
cord-287853-cob7ur35	20	9	non	non	JJ
cord-287853-cob7ur35	20	10	-	-	JJ
cord-287853-cob7ur35	20	11	human	human	JJ
cord-287853-cob7ur35	20	12	cell	cell	NN
cord-287853-cob7ur35	20	13	lines	line	NNS
cord-287853-cob7ur35	20	14	generate	generate	VBP
cord-287853-cob7ur35	20	15	glycans	glycan	NNS
cord-287853-cob7ur35	20	16	that	that	WDT
cord-287853-cob7ur35	20	17	are	be	VBP
cord-287853-cob7ur35	20	18	not	not	RB
cord-287853-cob7ur35	20	19	compatible	compatible	JJ
cord-287853-cob7ur35	20	20	and	and	CC
cord-287853-cob7ur35	20	21	bioactive	bioactive	JJ
cord-287853-cob7ur35	20	22	within	within	IN
cord-287853-cob7ur35	20	23	human	human	JJ
cord-287853-cob7ur35	20	24	hosts	host	NNS
cord-287853-cob7ur35	20	25	.	.	.
cord-287853-cob7ur35	21	1	18	18	CD
cord-287853-cob7ur35	22	1	Thus	thus	RB
cord-287853-cob7ur35	22	2	,	,	,
cord-287853-cob7ur35	22	3	about	about	RB
cord-287853-cob7ur35	22	4	70	70	CD
cord-287853-cob7ur35	22	5	%	%	NN
cord-287853-cob7ur35	22	6	of	of	IN
cord-287853-cob7ur35	22	7	all	all	DT
cord-287853-cob7ur35	22	8	recombinant	recombinant	JJ
cord-287853-cob7ur35	22	9	glycoproteins	glycoprotein	NNS
cord-287853-cob7ur35	22	10	are	be	VBP
cord-287853-cob7ur35	22	11	produced	produce	VBN
cord-287853-cob7ur35	22	12	in	in	IN
cord-287853-cob7ur35	22	13	mammalian	mammalian	NN
cord-287853-cob7ur35	22	14	-	-	HYPH
cord-287853-cob7ur35	22	15	based	base	VBN
cord-287853-cob7ur35	22	16	expression	expression	NN
cord-287853-cob7ur35	22	17	systems	system	NNS
cord-287853-cob7ur35	22	18	such	such	JJ
cord-287853-cob7ur35	22	19	as	as	IN
cord-287853-cob7ur35	22	20	Chinese	chinese	JJ
cord-287853-cob7ur35	22	21	Hamster	Hamster	NNP
cord-287853-cob7ur35	22	22	Ovary	Ovary	NNP
cord-287853-cob7ur35	22	23	(	(	-LRB-
cord-287853-cob7ur35	22	24	CHO	CHO	NNP
cord-287853-cob7ur35	22	25	)	)	-RRB-
cord-287853-cob7ur35	22	26	cells	cell	NNS
cord-287853-cob7ur35	22	27	.	.	.
cord-287853-cob7ur35	23	1	19	19	CD
cord-287853-cob7ur35	23	2	Analytical	analytical	JJ
cord-287853-cob7ur35	23	3	characterization	characterization	NN
cord-287853-cob7ur35	23	4	of	of	IN
cord-287853-cob7ur35	23	5	a	a	DT
cord-287853-cob7ur35	23	6	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	23	7	is	be	VBZ
cord-287853-cob7ur35	23	8	challenging	challenging	JJ
cord-287853-cob7ur35	23	9	as	as	IN
cord-287853-cob7ur35	23	10	there	there	EX
cord-287853-cob7ur35	23	11	is	be	VBZ
cord-287853-cob7ur35	23	12	inherent	inherent	JJ
cord-287853-cob7ur35	23	13	unpredictability	unpredictability	NN
cord-287853-cob7ur35	23	14	associated	associate	VBN
cord-287853-cob7ur35	23	15	with	with	IN
cord-287853-cob7ur35	23	16	the	the	DT
cord-287853-cob7ur35	23	17	glycans	glycan	NNS
cord-287853-cob7ur35	23	18	;	;	:
cord-287853-cob7ur35	23	19	they	-PRON-	PRP
cord-287853-cob7ur35	23	20	are	be	VBP
cord-287853-cob7ur35	23	21	either	either	RB
cord-287853-cob7ur35	23	22	macroheterogeneous	macroheterogeneous	JJ
cord-287853-cob7ur35	23	23	(	(	-LRB-
cord-287853-cob7ur35	23	24	potential	potential	JJ
cord-287853-cob7ur35	23	25	glycan	glycan	NN
cord-287853-cob7ur35	23	26	site	site	NN
cord-287853-cob7ur35	23	27	in	in	IN
cord-287853-cob7ur35	23	28	the	the	DT
cord-287853-cob7ur35	23	29	protein	protein	NN
cord-287853-cob7ur35	23	30	not	not	RB
cord-287853-cob7ur35	23	31	glycosylated	glycosylate	VBN
cord-287853-cob7ur35	23	32	)	)	-RRB-
cord-287853-cob7ur35	23	33	or	or	CC
cord-287853-cob7ur35	23	34	microheterogeneous	microheterogeneous	JJ
cord-287853-cob7ur35	23	35	(	(	-LRB-
cord-287853-cob7ur35	23	36	different	different	JJ
cord-287853-cob7ur35	23	37	glycan	glycan	NN
cord-287853-cob7ur35	23	38	structures	structure	NNS
cord-287853-cob7ur35	23	39	found	find	VBN
cord-287853-cob7ur35	23	40	on	on	IN
cord-287853-cob7ur35	23	41	the	the	DT
cord-287853-cob7ur35	23	42	same	same	JJ
cord-287853-cob7ur35	23	43	site	site	NN
cord-287853-cob7ur35	23	44	in	in	IN
cord-287853-cob7ur35	23	45	the	the	DT
cord-287853-cob7ur35	23	46	expressed	express	VBN
cord-287853-cob7ur35	23	47	protein	protein	NN
cord-287853-cob7ur35	23	48	)	)	-RRB-
cord-287853-cob7ur35	23	49	.	.	.
cord-287853-cob7ur35	24	1	Glycosylation	glycosylation	NN
cord-287853-cob7ur35	24	2	analysis	analysis	NN
cord-287853-cob7ur35	24	3	is	be	VBZ
cord-287853-cob7ur35	24	4	performed	perform	VBN
cord-287853-cob7ur35	24	5	to	to	TO
cord-287853-cob7ur35	24	6	understand	understand	VB
cord-287853-cob7ur35	24	7	the	the	DT
cord-287853-cob7ur35	24	8	nature	nature	NN
cord-287853-cob7ur35	24	9	of	of	IN
cord-287853-cob7ur35	24	10	structural	structural	JJ
cord-287853-cob7ur35	24	11	heterogeneity	heterogeneity	NN
cord-287853-cob7ur35	24	12	of	of	IN
cord-287853-cob7ur35	24	13	glycans	glycan	NNS
cord-287853-cob7ur35	24	14	,	,	,
cord-287853-cob7ur35	24	15	quantify	quantify	VB
cord-287853-cob7ur35	24	16	them	-PRON-	PRP
cord-287853-cob7ur35	24	17	,	,	,
cord-287853-cob7ur35	24	18	and	and	CC
cord-287853-cob7ur35	24	19	more	more	RBR
cord-287853-cob7ur35	24	20	importantly	importantly	RB
cord-287853-cob7ur35	24	21	to	to	TO
cord-287853-cob7ur35	24	22	determine	determine	VB
cord-287853-cob7ur35	24	23	where	where	WRB
cord-287853-cob7ur35	24	24	glycosylation	glycosylation	NN
cord-287853-cob7ur35	24	25	occurs	occur	VBZ
cord-287853-cob7ur35	24	26	(	(	-LRB-
cord-287853-cob7ur35	24	27	site	site	NN
cord-287853-cob7ur35	24	28	specific	specific	JJ
cord-287853-cob7ur35	24	29	analysis	analysis	NN
cord-287853-cob7ur35	24	30	)	)	-RRB-
cord-287853-cob7ur35	24	31	.	.	.
cord-287853-cob7ur35	25	1	Mass	mass	NN
cord-287853-cob7ur35	25	2	spectrometry	spectrometry	NN
cord-287853-cob7ur35	25	3	based	base	VBN
cord-287853-cob7ur35	25	4	techniques	technique	NNS
cord-287853-cob7ur35	25	5	are	be	VBP
cord-287853-cob7ur35	25	6	valuable	valuable	JJ
cord-287853-cob7ur35	25	7	tool	tool	NN
cord-287853-cob7ur35	25	8	for	for	IN
cord-287853-cob7ur35	25	9	detecting	detect	VBG
cord-287853-cob7ur35	25	10	and	and	CC
cord-287853-cob7ur35	25	11	investigating	investigate	VBG
cord-287853-cob7ur35	25	12	glycosylation	glycosylation	NN
cord-287853-cob7ur35	25	13	(	(	-LRB-
cord-287853-cob7ur35	25	14	Figure	figure	NN
cord-287853-cob7ur35	25	15	2	2	CD
cord-287853-cob7ur35	25	16	)	)	-RRB-
cord-287853-cob7ur35	25	17	.	.	.
cord-287853-cob7ur35	26	1	Although	although	IN
cord-287853-cob7ur35	26	2	MS	MS	NNP
cord-287853-cob7ur35	26	3	-	-	HYPH
cord-287853-cob7ur35	26	4	based	base	VBN
cord-287853-cob7ur35	26	5	glycosylation	glycosylation	NN
cord-287853-cob7ur35	26	6	analysis	analysis	NN
cord-287853-cob7ur35	26	7	is	be	VBZ
cord-287853-cob7ur35	26	8	not	not	RB
cord-287853-cob7ur35	26	9	without	without	IN
cord-287853-cob7ur35	26	10	limitations	limitation	NNS
cord-287853-cob7ur35	26	11	,	,	,
cord-287853-cob7ur35	26	12	the	the	DT
cord-287853-cob7ur35	26	13	advances	advance	NNS
cord-287853-cob7ur35	26	14	in	in	IN
cord-287853-cob7ur35	26	15	MS	MS	NNP
cord-287853-cob7ur35	26	16	instrumentation	instrumentation	NN
cord-287853-cob7ur35	26	17	and	and	CC
cord-287853-cob7ur35	26	18	glycan	glycan	NN
cord-287853-cob7ur35	26	19	analysis	analysis	NN
cord-287853-cob7ur35	26	20	software	software	NN
cord-287853-cob7ur35	26	21	have	have	VBP
cord-287853-cob7ur35	26	22	led	lead	VBN
cord-287853-cob7ur35	26	23	to	to	IN
cord-287853-cob7ur35	26	24	increased	increase	VBN
cord-287853-cob7ur35	26	25	resolution	resolution	NN
cord-287853-cob7ur35	26	26	,	,	,
cord-287853-cob7ur35	26	27	automated	automate	VBN
cord-287853-cob7ur35	26	28	identification	identification	NN
cord-287853-cob7ur35	26	29	,	,	,
cord-287853-cob7ur35	26	30	quantitative	quantitative	JJ
cord-287853-cob7ur35	26	31	determination	determination	NN
cord-287853-cob7ur35	26	32	,	,	,
cord-287853-cob7ur35	26	33	and	and	CC
cord-287853-cob7ur35	26	34	accurate	accurate	JJ
cord-287853-cob7ur35	26	35	structural	structural	JJ
cord-287853-cob7ur35	26	36	characterization	characterization	NN
cord-287853-cob7ur35	26	37	.	.	.
cord-287853-cob7ur35	27	1	16	16	CD
cord-287853-cob7ur35	27	2	,	,	,
cord-287853-cob7ur35	27	3	20	20	CD
cord-287853-cob7ur35	27	4	,	,	,
cord-287853-cob7ur35	27	5	21	21	CD
cord-287853-cob7ur35	28	1	Another	another	DT
cord-287853-cob7ur35	28	2	critical	critical	JJ
cord-287853-cob7ur35	28	3	quality	quality	NN
cord-287853-cob7ur35	28	4	attribute	attribute	NN
cord-287853-cob7ur35	28	5	(	(	-LRB-
cord-287853-cob7ur35	28	6	CQA	CQA	NNP
cord-287853-cob7ur35	28	7	)	)	-RRB-
cord-287853-cob7ur35	28	8	of	of	IN
cord-287853-cob7ur35	28	9	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	28	10	is	be	VBZ
cord-287853-cob7ur35	28	11	intramolecular	intramolecular	JJ
cord-287853-cob7ur35	28	12	disulfide	disulfide	JJ
cord-287853-cob7ur35	28	13	bonds	bond	NNS
cord-287853-cob7ur35	28	14	(	(	-LRB-
cord-287853-cob7ur35	28	15	S	S	NNP
cord-287853-cob7ur35	28	16	-	-	HYPH
cord-287853-cob7ur35	28	17	S	S	NNP
cord-287853-cob7ur35	28	18	linkages	linkage	NNS
cord-287853-cob7ur35	28	19	)	)	-RRB-
cord-287853-cob7ur35	28	20	;	;	:
cord-287853-cob7ur35	28	21	they	-PRON-	PRP
cord-287853-cob7ur35	28	22	ensure	ensure	VBP
cord-287853-cob7ur35	28	23	correct	correct	JJ
cord-287853-cob7ur35	28	24	folding	folding	NN
cord-287853-cob7ur35	28	25	,	,	,
cord-287853-cob7ur35	28	26	functional	functional	JJ
cord-287853-cob7ur35	28	27	activity	activity	NN
cord-287853-cob7ur35	28	28	and	and	CC
cord-287853-cob7ur35	28	29	stability	stability	NN
cord-287853-cob7ur35	28	30	.	.	.
cord-287853-cob7ur35	29	1	Incorrect	incorrect	JJ
cord-287853-cob7ur35	29	2	formation	formation	NN
cord-287853-cob7ur35	29	3	of	of	IN
cord-287853-cob7ur35	29	4	disulfide	disulfide	JJ
cord-287853-cob7ur35	29	5	bonds	bond	NNS
cord-287853-cob7ur35	29	6	can	can	MD
cord-287853-cob7ur35	29	7	cause	cause	VB
cord-287853-cob7ur35	29	8	protein	protein	NN
cord-287853-cob7ur35	29	9	misfolding	misfolding	NN
cord-287853-cob7ur35	29	10	which	which	WDT
cord-287853-cob7ur35	29	11	tends	tend	VBZ
cord-287853-cob7ur35	29	12	to	to	TO
cord-287853-cob7ur35	29	13	promote	promote	VB
cord-287853-cob7ur35	29	14	aggregation	aggregation	NN
cord-287853-cob7ur35	29	15	which	which	WDT
cord-287853-cob7ur35	29	16	could	could	MD
cord-287853-cob7ur35	29	17	result	result	VB
cord-287853-cob7ur35	29	18	in	in	IN
cord-287853-cob7ur35	29	19	an	an	DT
cord-287853-cob7ur35	29	20	unwarranted	unwarranted	JJ
cord-287853-cob7ur35	29	21	immune	immune	JJ
cord-287853-cob7ur35	29	22	response	response	NN
cord-287853-cob7ur35	29	23	.	.	.
cord-287853-cob7ur35	30	1	Confirmation	confirmation	NN
cord-287853-cob7ur35	30	2	of	of	IN
cord-287853-cob7ur35	30	3	correct	correct	JJ
cord-287853-cob7ur35	30	4	disulfide	disulfide	JJ
cord-287853-cob7ur35	30	5	bond	bond	NN
cord-287853-cob7ur35	30	6	formation	formation	NN
cord-287853-cob7ur35	30	7	in	in	IN
cord-287853-cob7ur35	30	8	the	the	DT
cord-287853-cob7ur35	30	9	recombinant	recombinant	JJ
cord-287853-cob7ur35	30	10	First	First	NNP
cord-287853-cob7ur35	30	11	study	study	NN
cord-287853-cob7ur35	30	12	analyzing	analyze	VBG
cord-287853-cob7ur35	30	13	the	the	DT
cord-287853-cob7ur35	30	14	site	site	NN
cord-287853-cob7ur35	30	15	-	-	HYPH
cord-287853-cob7ur35	30	16	specific	specific	JJ
cord-287853-cob7ur35	30	17	Nglycosylation	Nglycosylation	NNP
cord-287853-cob7ur35	30	18	of	of	IN
cord-287853-cob7ur35	30	19	gp120	gp120	NNP
cord-287853-cob7ur35	30	20	.	.	.
cord-287853-cob7ur35	31	1	This	this	DT
cord-287853-cob7ur35	31	2	report	report	NN
cord-287853-cob7ur35	31	3	describes	describe	VBZ
cord-287853-cob7ur35	31	4	the	the	DT
cord-287853-cob7ur35	31	5	structural	structural	JJ
cord-287853-cob7ur35	31	6	characterization	characterization	NN
cord-287853-cob7ur35	31	7	of	of	IN
cord-287853-cob7ur35	31	8	the	the	DT
cord-287853-cob7ur35	31	9	expressed	express	VBN
cord-287853-cob7ur35	31	10	gp120	gp120	CD
cord-287853-cob7ur35	31	11	.	.	.
cord-287853-cob7ur35	32	1	Reversed	reversed	JJ
cord-287853-cob7ur35	32	2	phase	phase	NN
cord-287853-cob7ur35	32	3	HPLC	HPLC	NNP
cord-287853-cob7ur35	32	4	of	of	IN
cord-287853-cob7ur35	32	5	the	the	DT
cord-287853-cob7ur35	32	6	tryptic	tryptic	NNP
cord-287853-cob7ur35	32	7	digest	digest	NNP
cord-287853-cob7ur35	32	8	.	.	.
cord-287853-cob7ur35	33	1	Peptides	peptide	NNS
cord-287853-cob7ur35	33	2	collected	collect	VBN
cord-287853-cob7ur35	33	3	from	from	IN
cord-287853-cob7ur35	33	4	RP	RP	NNP
cord-287853-cob7ur35	33	5	-	-	HYPH
cord-287853-cob7ur35	33	6	HPLC	HPLC	NNP
cord-287853-cob7ur35	33	7	were	be	VBD
cord-287853-cob7ur35	33	8	further	further	RB
cord-287853-cob7ur35	33	9	identified	identify	VBN
cord-287853-cob7ur35	33	10	by	by	IN
cord-287853-cob7ur35	33	11	amino	amino	NN
cord-287853-cob7ur35	33	12	acid	acid	NN
cord-287853-cob7ur35	33	13	analysis	analysis	NN
cord-287853-cob7ur35	33	14	(	(	-LRB-
cord-287853-cob7ur35	33	15	AAA	AAA	NNP
cord-287853-cob7ur35	33	16	)	)	-RRB-
cord-287853-cob7ur35	33	17	or	or	CC
cord-287853-cob7ur35	33	18	Nterminal	Nterminal	NNP
cord-287853-cob7ur35	33	19	sequencing	sequencing	NN
cord-287853-cob7ur35	33	20	analysis	analysis	NN
cord-287853-cob7ur35	33	21	.	.	.
cord-287853-cob7ur35	34	1	Leonard	Leonard	NNP
cord-287853-cob7ur35	34	2	et	et	NNP
cord-287853-cob7ur35	34	3	al	al	NNP
cord-287853-cob7ur35	35	1	38	38	CD
cord-287853-cob7ur35	35	2	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	35	3	gp120	gp120	NNP
cord-287853-cob7ur35	35	4	Expressed	express	VBN
cord-287853-cob7ur35	35	5	in	in	IN
cord-287853-cob7ur35	35	6	CHO	CHO	NNP
cord-287853-cob7ur35	35	7	Cells	Cells	NNP
cord-287853-cob7ur35	35	8	.	.	.
cord-287853-cob7ur35	36	1	Mass	mass	JJ
cord-287853-cob7ur35	36	2	spectrometric	spectrometric	JJ
cord-287853-cob7ur35	36	3	characterization	characterization	NN
cord-287853-cob7ur35	36	4	of	of	IN
cord-287853-cob7ur35	36	5	the	the	DT
cord-287853-cob7ur35	36	6	glycosylation	glycosylation	NN
cord-287853-cob7ur35	36	7	pattern	pattern	NN
cord-287853-cob7ur35	36	8	.	.	.
cord-287853-cob7ur35	37	1	Of	of	IN
cord-287853-cob7ur35	37	2	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	37	3	gp120	gp120	NNP
cord-287853-cob7ur35	37	4	.	.	.
cord-287853-cob7ur35	38	1	MALDI	MALDI	NNP
cord-287853-cob7ur35	38	2	and	and	CC
cord-287853-cob7ur35	38	3	nanoESI	nanoESI	NNP
cord-287853-cob7ur35	38	4	-	-	HYPH
cord-287853-cob7ur35	38	5	LC	LC	NNP
cord-287853-cob7ur35	38	6	-	-	HYPH
cord-287853-cob7ur35	38	7	MS	MS	NNP
cord-287853-cob7ur35	38	8	/	/	SYM
cord-287853-cob7ur35	38	9	MS	MS	NNP
cord-287853-cob7ur35	38	10	using	use	VBG
cord-287853-cob7ur35	38	11	a	a	DT
cord-287853-cob7ur35	38	12	hybrid	hybrid	JJ
cord-287853-cob7ur35	38	13	quadrupole	quadrupole	JJ
cord-287853-cob7ur35	38	14	-	-	HYPH
cord-287853-cob7ur35	38	15	time	time	NN
cord-287853-cob7ur35	38	16	-	-	HYPH
cord-287853-cob7ur35	38	17	of	of	IN
cord-287853-cob7ur35	38	18	-	-	HYPH
cord-287853-cob7ur35	38	19	flight	flight	NN
cord-287853-cob7ur35	38	20	tandem	tandem	NN
cord-287853-cob7ur35	38	21	mass	mass	NN
cord-287853-cob7ur35	38	22	spectrometer	spectrometer	NN
cord-287853-cob7ur35	38	23	(	(	-LRB-
cord-287853-cob7ur35	38	24	Q	Q	NNP
cord-287853-cob7ur35	38	25	-	-	HYPH
cord-287853-cob7ur35	38	26	TOF	TOF	NNP
cord-287853-cob7ur35	38	27	)	)	-RRB-
cord-287853-cob7ur35	38	28	was	be	VBD
cord-287853-cob7ur35	38	29	used	use	VBN
cord-287853-cob7ur35	38	30	to	to	TO
cord-287853-cob7ur35	38	31	assign	assign	VB
cord-287853-cob7ur35	38	32	glycosylation	glycosylation	NN
cord-287853-cob7ur35	38	33	sites	site	NNS
cord-287853-cob7ur35	38	34	.	.	.
cord-287853-cob7ur35	39	1	Zhu	Zhu	NNP
cord-287853-cob7ur35	39	2	et	et	NNP
cord-287853-cob7ur35	39	3	al	al	NNP
cord-287853-cob7ur35	39	4	111	111	CD
cord-287853-cob7ur35	40	1	HIV	HIV	NNP
cord-287853-cob7ur35	40	2	gp140	gp140	NNP
cord-287853-cob7ur35	40	3	JR	JR	NNP
cord-287853-cob7ur35	40	4	-	-	HYPH
cord-287853-cob7ur35	40	5	FL	FL	NNP
cord-287853-cob7ur35	40	6	and	and	CC
cord-287853-cob7ur35	40	7	CON	CON	NNP
cord-287853-cob7ur35	40	8	-	-	HYPH
cord-287853-cob7ur35	40	9	S	S	NNP
cord-287853-cob7ur35	40	10	Env	Env	NNP
cord-287853-cob7ur35	40	11	expressed	express	VBD
cord-287853-cob7ur35	40	12	in	in	IN
cord-287853-cob7ur35	40	13	CHO	CHO	NNP
cord-287853-cob7ur35	40	14	and	and	CC
cord-287853-cob7ur35	40	15	HEK293	HEK293	NNP
cord-287853-cob7ur35	40	16	cells	cell	NNS
cord-287853-cob7ur35	40	17	.	.	.
cord-287853-cob7ur35	41	1	A	a	DT
cord-287853-cob7ur35	41	2	glycopeptide	glycopeptide	NN
cord-287853-cob7ur35	41	3	-	-	HYPH
cord-287853-cob7ur35	41	4	based	base	VBN
cord-287853-cob7ur35	41	5	mass	mass	NN
cord-287853-cob7ur35	41	6	mapping	mapping	NN
cord-287853-cob7ur35	41	7	approach	approach	NN
cord-287853-cob7ur35	41	8	was	be	VBD
cord-287853-cob7ur35	41	9	used	use	VBN
cord-287853-cob7ur35	41	10	to	to	TO
cord-287853-cob7ur35	41	11	characterize	characterize	VB
cord-287853-cob7ur35	41	12	the	the	DT
cord-287853-cob7ur35	41	13	glycosylation	glycosylation	NN
cord-287853-cob7ur35	41	14	of	of	IN
cord-287853-cob7ur35	41	15	two	two	CD
cord-287853-cob7ur35	41	16	Env	Env	NNP
cord-287853-cob7ur35	41	17	protein	protein	NN
cord-287853-cob7ur35	41	18	vaccine	vaccine	NN
cord-287853-cob7ur35	41	19	candidates	candidate	NNS
cord-287853-cob7ur35	41	20	in	in	IN
cord-287853-cob7ur35	41	21	a	a	DT
cord-287853-cob7ur35	41	22	glycosylation	glycosylation	NN
cord-287853-cob7ur35	41	23	site	site	NN
cord-287853-cob7ur35	41	24	-	-	HYPH
cord-287853-cob7ur35	41	25	specific	specific	JJ
cord-287853-cob7ur35	41	26	fashion	fashion	NN
cord-287853-cob7ur35	41	27	.	.	.
cord-287853-cob7ur35	42	1	Mass	mass	NN
cord-287853-cob7ur35	42	2	spectrometry	spectrometry	NN
cord-287853-cob7ur35	42	3	based	base	VBN
cord-287853-cob7ur35	42	4	approach	approach	NN
cord-287853-cob7ur35	42	5	was	be	VBD
cord-287853-cob7ur35	42	6	used	use	VBN
cord-287853-cob7ur35	42	7	to	to	TO
cord-287853-cob7ur35	42	8	map	map	VB
cord-287853-cob7ur35	42	9	the	the	DT
cord-287853-cob7ur35	42	10	complete	complete	JJ
cord-287853-cob7ur35	42	11	glycosylation	glycosylation	NN
cord-287853-cob7ur35	42	12	profile	profile	NN
cord-287853-cob7ur35	42	13	at	at	IN
cord-287853-cob7ur35	42	14	every	every	DT
cord-287853-cob7ur35	42	15	site	site	NN
cord-287853-cob7ur35	42	16	in	in	IN
cord-287853-cob7ur35	42	17	eleven	eleven	CD
cord-287853-cob7ur35	42	18	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	42	19	Env	Env	NNP
cord-287853-cob7ur35	42	20	trimers	trimer	NNS
cord-287853-cob7ur35	42	21	.	.	.
cord-287853-cob7ur35	43	1	High	high	JJ
cord-287853-cob7ur35	43	2	-	-	HYPH
cord-287853-cob7ur35	43	3	resolution	resolution	NN
cord-287853-cob7ur35	43	4	LC	LC	NNP
cord-287853-cob7ur35	43	5	-	-	HYPH
cord-287853-cob7ur35	43	6	MS	MS	NNP
cord-287853-cob7ur35	43	7	/	/	SYM
cord-287853-cob7ur35	43	8	MS	MS	NNP
cord-287853-cob7ur35	43	9	was	be	VBD
cord-287853-cob7ur35	43	10	performed	perform	VBN
cord-287853-cob7ur35	43	11	using	use	VBG
cord-287853-cob7ur35	43	12	an	an	DT
cord-287853-cob7ur35	43	13	Orbitrap	Orbitrap	NNP
cord-287853-cob7ur35	43	14	Velos	Velos	NNP
cord-287853-cob7ur35	43	15	Pro	pro	JJ
cord-287853-cob7ur35	43	16	hybrid	hybrid	JJ
cord-287853-cob7ur35	43	17	mass	mass	NN
cord-287853-cob7ur35	43	18	spectrometer	spectrometer	NN
cord-287853-cob7ur35	43	19	(	(	-LRB-
cord-287853-cob7ur35	43	20	Thermo	Thermo	NNP
cord-287853-cob7ur35	43	21	Scientific	Scientific	NNP
cord-287853-cob7ur35	43	22	)	)	-RRB-
cord-287853-cob7ur35	43	23	equipped	equip	VBN
cord-287853-cob7ur35	43	24	with	with	IN
cord-287853-cob7ur35	43	25	ETD	ETD	NNP
cord-287853-cob7ur35	43	26	and	and	CC
cord-287853-cob7ur35	43	27	coupled	couple	VBN
cord-287853-cob7ur35	43	28	to	to	IN
cord-287853-cob7ur35	43	29	an	an	DT
cord-287853-cob7ur35	43	30	Acquity	Acquity	NNP
cord-287853-cob7ur35	43	31	UPLC	UPLC	NNP
cord-287853-cob7ur35	43	32	system	system	NN
cord-287853-cob7ur35	43	33	(	(	-LRB-
cord-287853-cob7ur35	43	34	Waters	Waters	NNP
cord-287853-cob7ur35	43	35	)	)	-RRB-
cord-287853-cob7ur35	43	36	.	.	.
cord-287853-cob7ur35	44	1	Go	go	VB
cord-287853-cob7ur35	44	2	et	et	FW
cord-287853-cob7ur35	44	3	al	al	NNP
cord-287853-cob7ur35	44	4	49	49	CD
cord-287853-cob7ur35	44	5	HIV	HIV	NNP
cord-287853-cob7ur35	45	1	gp120	gp120	NNP
cord-287853-cob7ur35	45	2	Monomers	monomer	NNS
cord-287853-cob7ur35	45	3	of	of	IN
cord-287853-cob7ur35	45	4	the	the	DT
cord-287853-cob7ur35	45	5	BG505	bg505	NN
cord-287853-cob7ur35	45	6	.	.	.
cord-287853-cob7ur35	46	1	SOSIP	SOSIP	NNP
cord-287853-cob7ur35	46	2	.	.	.
cord-287853-cob7ur35	47	1	Global	Global	NNP
cord-287853-cob7ur35	47	2	N	n	CD
cord-287853-cob7ur35	47	3	-	-	HYPH
cord-287853-cob7ur35	47	4	Glycan	Glycan	NNP
cord-287853-cob7ur35	47	5	site	site	NN
cord-287853-cob7ur35	47	6	occupancy	occupancy	NN
cord-287853-cob7ur35	47	7	of	of	IN
cord-287853-cob7ur35	47	8	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	47	9	gp120	gp120	NNP
cord-287853-cob7ur35	47	10	by	by	IN
cord-287853-cob7ur35	47	11	metabolic	metabolic	JJ
cord-287853-cob7ur35	47	12	engineering	engineering	NN
cord-287853-cob7ur35	47	13	and	and	CC
cord-287853-cob7ur35	47	14	high	high	JJ
cord-287853-cob7ur35	47	15	-	-	HYPH
cord-287853-cob7ur35	47	16	resolution	resolution	NN
cord-287853-cob7ur35	48	1	intact	intact	JJ
cord-287853-cob7ur35	49	1	mass	mass	NNP
cord-287853-cob7ur35	49	2	spectrometry	spectrometry	NNP
cord-287853-cob7ur35	49	3	was	be	VBD
cord-287853-cob7ur35	49	4	performed	perform	VBN
cord-287853-cob7ur35	49	5	.	.	.
cord-287853-cob7ur35	50	1	Released	release	VBN
cord-287853-cob7ur35	50	2	N	n	CD
cord-287853-cob7ur35	50	3	-	-	HYPH
cord-287853-cob7ur35	50	4	glycan	glycan	NN
cord-287853-cob7ur35	50	5	analysis	analysis	NN
cord-287853-cob7ur35	50	6	was	be	VBD
cord-287853-cob7ur35	50	7	carried	carry	VBN
cord-287853-cob7ur35	50	8	out	out	RP
cord-287853-cob7ur35	50	9	using	use	VBG
cord-287853-cob7ur35	50	10	Synapt	Synapt	NNP
cord-287853-cob7ur35	50	11	G2Si	g2si	POS
cord-287853-cob7ur35	50	12	ion	ion	NN
cord-287853-cob7ur35	50	13	mobility	mobility	NN
cord-287853-cob7ur35	50	14	mass	mass	NN
cord-287853-cob7ur35	50	15	spectrometer	spectrometer	NN
cord-287853-cob7ur35	50	16	.	.	.
cord-287853-cob7ur35	51	1	Native	native	JJ
cord-287853-cob7ur35	51	2	highresolution	highresolution	NN
cord-287853-cob7ur35	51	3	mass	mass	NN
cord-287853-cob7ur35	51	4	spectrometry	spectrometry	NN
cord-287853-cob7ur35	51	5	was	be	VBD
cord-287853-cob7ur35	51	6	performed	perform	VBN
cord-287853-cob7ur35	51	7	on	on	IN
cord-287853-cob7ur35	51	8	Q	Q	NNP
cord-287853-cob7ur35	51	9	Exactive	Exactive	NNP
cord-287853-cob7ur35	51	10	hybrid	hybrid	NN
cord-287853-cob7ur35	51	11	Quadrupole	Quadrupole	NNP
cord-287853-cob7ur35	51	12	-	-	HYPH
cord-287853-cob7ur35	51	13	Orbitrap	Orbitrap	NNP
cord-287853-cob7ur35	51	14	mass	mass	NN
cord-287853-cob7ur35	51	15	spectrometer	spectrometer	NN
cord-287853-cob7ur35	51	16	.	.	.
cord-287853-cob7ur35	52	1	As	as	IN
cord-287853-cob7ur35	52	2	illustrated	illustrate	VBN
cord-287853-cob7ur35	52	3	in	in	IN
cord-287853-cob7ur35	52	4	the	the	DT
cord-287853-cob7ur35	52	5	following	follow	VBG
cord-287853-cob7ur35	52	6	section	section	NN
cord-287853-cob7ur35	52	7	and	and	CC
cord-287853-cob7ur35	52	8	in	in	IN
cord-287853-cob7ur35	52	9	Table	Table	NNP
cord-287853-cob7ur35	52	10	1	1	CD
cord-287853-cob7ur35	52	11	,	,	,
cord-287853-cob7ur35	52	12	mass	mass	NN
cord-287853-cob7ur35	52	13	spectrometry	spectrometry	NN
cord-287853-cob7ur35	52	14	-	-	HYPH
cord-287853-cob7ur35	52	15	based	base	VBN
cord-287853-cob7ur35	52	16	techniques	technique	NNS
cord-287853-cob7ur35	52	17	have	have	VBP
cord-287853-cob7ur35	52	18	been	be	VBN
cord-287853-cob7ur35	52	19	used	use	VBN
cord-287853-cob7ur35	52	20	to	to	TO
cord-287853-cob7ur35	52	21	perform	perform	VB
cord-287853-cob7ur35	52	22	the	the	DT
cord-287853-cob7ur35	52	23	structural	structural	JJ
cord-287853-cob7ur35	52	24	characterization	characterization	NN
cord-287853-cob7ur35	52	25	,	,	,
cord-287853-cob7ur35	52	26	glycosylation	glycosylation	NN
cord-287853-cob7ur35	52	27	profiling	profiling	NN
cord-287853-cob7ur35	52	28	and	and	CC
cord-287853-cob7ur35	52	29	antigen	antigen	NN
cord-287853-cob7ur35	52	30	quantitation	quantitation	NN
cord-287853-cob7ur35	52	31	during	during	IN
cord-287853-cob7ur35	52	32	the	the	DT
cord-287853-cob7ur35	52	33	development	development	NN
cord-287853-cob7ur35	52	34	of	of	IN
cord-287853-cob7ur35	52	35	the	the	DT
cord-287853-cob7ur35	52	36	HIV	HIV	NNP
cord-287853-cob7ur35	52	37	,	,	,
cord-287853-cob7ur35	52	38	influenza	influenza	NN
cord-287853-cob7ur35	52	39	,	,	,
cord-287853-cob7ur35	52	40	Dengue	Dengue	NNP
cord-287853-cob7ur35	52	41	,	,	,
cord-287853-cob7ur35	52	42	Ebola	Ebola	NNP
cord-287853-cob7ur35	52	43	,	,	,
cord-287853-cob7ur35	52	44	Meningococcal	Meningococcal	NNP
cord-287853-cob7ur35	52	45	,	,	,
cord-287853-cob7ur35	52	46	and	and	CC
cord-287853-cob7ur35	52	47	other	other	JJ
cord-287853-cob7ur35	52	48	vaccines	vaccine	NNS
cord-287853-cob7ur35	52	49	.	.	.
cord-287853-cob7ur35	53	1	The	the	DT
cord-287853-cob7ur35	53	2	review	review	NN
cord-287853-cob7ur35	53	3	also	also	RB
cord-287853-cob7ur35	53	4	highlights	highlight	VBZ
cord-287853-cob7ur35	53	5	that	that	IN
cord-287853-cob7ur35	53	6	mass	mass	NN
cord-287853-cob7ur35	53	7	spectrometry	spectrometry	NN
cord-287853-cob7ur35	53	8	-	-	HYPH
cord-287853-cob7ur35	53	9	based	base	VBN
cord-287853-cob7ur35	53	10	methods	method	NNS
cord-287853-cob7ur35	53	11	such	such	JJ
cord-287853-cob7ur35	53	12	as	as	IN
cord-287853-cob7ur35	53	13	glycan	glycan	NN
cord-287853-cob7ur35	53	14	analysis	analysis	NN
cord-287853-cob7ur35	53	15	has	have	VBZ
cord-287853-cob7ur35	53	16	been	be	VBN
cord-287853-cob7ur35	53	17	used	use	VBN
cord-287853-cob7ur35	53	18	to	to	TO
cord-287853-cob7ur35	53	19	analyze	analyze	VB
cord-287853-cob7ur35	53	20	a	a	DT
cord-287853-cob7ur35	53	21	specific	specific	JJ
cord-287853-cob7ur35	53	22	envelope	envelope	NN
cord-287853-cob7ur35	53	23	glycoproteins	glycoprotein	NNS
cord-287853-cob7ur35	53	24	(	(	-LRB-
cord-287853-cob7ur35	53	25	Env	Env	NNP
cord-287853-cob7ur35	53	26	)	)	-RRB-
cord-287853-cob7ur35	53	27	and	and	CC
cord-287853-cob7ur35	53	28	has	have	VBZ
cord-287853-cob7ur35	53	29	broad	broad	JJ
cord-287853-cob7ur35	53	30	applicability	applicability	NN
cord-287853-cob7ur35	53	31	to	to	IN
cord-287853-cob7ur35	53	32	any	any	DT
cord-287853-cob7ur35	53	33	other	other	JJ
cord-287853-cob7ur35	53	34	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	53	35	-	-	HYPH
cord-287853-cob7ur35	53	36	based	base	VBN
cord-287853-cob7ur35	53	37	vaccines	vaccine	NNS
cord-287853-cob7ur35	53	38	.	.	.
cord-287853-cob7ur35	54	1	The	the	DT
cord-287853-cob7ur35	54	2	quest	quest	NN
cord-287853-cob7ur35	54	3	for	for	IN
cord-287853-cob7ur35	54	4	a	a	DT
cord-287853-cob7ur35	54	5	safe	safe	JJ
cord-287853-cob7ur35	54	6	and	and	CC
cord-287853-cob7ur35	54	7	effective	effective	JJ
cord-287853-cob7ur35	54	8	vaccine	vaccine	NN
cord-287853-cob7ur35	54	9	to	to	TO
cord-287853-cob7ur35	54	10	protect	protect	VB
cord-287853-cob7ur35	54	11	against	against	IN
cord-287853-cob7ur35	54	12	human	human	JJ
cord-287853-cob7ur35	54	13	One	one	CD
cord-287853-cob7ur35	54	14	of	of	IN
cord-287853-cob7ur35	54	15	the	the	DT
cord-287853-cob7ur35	54	16	hypotheses	hypothesis	NNS
cord-287853-cob7ur35	54	17	being	be	VBG
cord-287853-cob7ur35	54	18	explored	explore	VBN
cord-287853-cob7ur35	54	19	for	for	IN
cord-287853-cob7ur35	54	20	protective	protective	JJ
cord-287853-cob7ur35	54	21	immunity	immunity	NN
cord-287853-cob7ur35	54	22	against	against	IN
cord-287853-cob7ur35	54	23	HIV	HIV	NNP
cord-287853-cob7ur35	54	24	is	be	VBZ
cord-287853-cob7ur35	54	25	to	to	TO
cord-287853-cob7ur35	54	26	induce	induce	VB
cord-287853-cob7ur35	54	27	broadly	broadly	RB
cord-287853-cob7ur35	54	28	neutralizing	neutralize	VBG
cord-287853-cob7ur35	54	29	antibodies	antibody	NNS
cord-287853-cob7ur35	54	30	(	(	-LRB-
cord-287853-cob7ur35	54	31	bNAbs	bnabs	NN
cord-287853-cob7ur35	54	32	)	)	-RRB-
cord-287853-cob7ur35	54	33	that	that	WDT
cord-287853-cob7ur35	54	34	target	target	VBP
cord-287853-cob7ur35	54	35	the	the	DT
cord-287853-cob7ur35	54	36	highly	highly	RB
cord-287853-cob7ur35	54	37	glycosylated	glycosylated	JJ
cord-287853-cob7ur35	54	38	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	54	39	virion	virion	NN
cord-287853-cob7ur35	54	40	-	-	HYPH
cord-287853-cob7ur35	54	41	associated	associate	VBN
cord-287853-cob7ur35	54	42	Envelop	Envelop	NNP
cord-287853-cob7ur35	54	43	.	.	.
cord-287853-cob7ur35	55	1	33	33	CD
cord-287853-cob7ur35	56	1	A	a	DT
cord-287853-cob7ur35	56	2	number	number	NN
cord-287853-cob7ur35	56	3	of	of	IN
cord-287853-cob7ur35	56	4	approaches	approach	NNS
cord-287853-cob7ur35	56	5	are	be	VBP
cord-287853-cob7ur35	56	6	being	be	VBG
cord-287853-cob7ur35	56	7	pursued	pursue	VBN
cord-287853-cob7ur35	56	8	in	in	IN
cord-287853-cob7ur35	56	9	the	the	DT
cord-287853-cob7ur35	56	10	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	56	11	vaccine	vaccine	NN
cord-287853-cob7ur35	56	12	development	development	NN
cord-287853-cob7ur35	56	13	field	field	NN
cord-287853-cob7ur35	56	14	to	to	TO
cord-287853-cob7ur35	56	15	establish	establish	VB
cord-287853-cob7ur35	56	16	protective	protective	JJ
cord-287853-cob7ur35	56	17	immunity	immunity	NN
cord-287853-cob7ur35	56	18	,	,	,
cord-287853-cob7ur35	56	19	including	include	VBG
cord-287853-cob7ur35	56	20	monomeric	monomeric	JJ
cord-287853-cob7ur35	56	21	gp120	gp120	NNP
cord-287853-cob7ur35	56	22	subunits	subunit	NNS
cord-287853-cob7ur35	56	23	and	and	CC
cord-287853-cob7ur35	56	24	oligomeric	oligomeric	JJ
cord-287853-cob7ur35	56	25	gp140	gp140	DT
cord-287853-cob7ur35	56	26	and	and	CC
cord-287853-cob7ur35	56	27	trimeric	trimeric	NNP
cord-287853-cob7ur35	56	28	envelope	envelope	NN
cord-287853-cob7ur35	56	29	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	56	30	to	to	TO
cord-287853-cob7ur35	56	31	elicit	elicit	VB
cord-287853-cob7ur35	56	32	bNAbs	bnabs	NN
cord-287853-cob7ur35	56	33	.	.	.
cord-287853-cob7ur35	57	1	[	[	-LRB-
cord-287853-cob7ur35	57	2	34	34	CD
cord-287853-cob7ur35	57	3	]	]	-RRB-
cord-287853-cob7ur35	57	4	[	[	-LRB-
cord-287853-cob7ur35	57	5	35	35	CD
cord-287853-cob7ur35	57	6	]	]	-RRB-
cord-287853-cob7ur35	58	1	[	[	-LRB-
cord-287853-cob7ur35	58	2	36	36	CD
cord-287853-cob7ur35	58	3	]	]	-RRB-
cord-287853-cob7ur35	59	1	Each	each	DT
cord-287853-cob7ur35	59	2	of	of	IN
cord-287853-cob7ur35	59	3	these	these	DT
cord-287853-cob7ur35	59	4	Envelop	Envelop	NNP
cord-287853-cob7ur35	59	5	(	(	-LRB-
cord-287853-cob7ur35	59	6	Env	Env	NNP
cord-287853-cob7ur35	59	7	)	)	-RRB-
cord-287853-cob7ur35	59	8	immunogens	immunogen	NNS
cord-287853-cob7ur35	59	9	have	have	VBP
cord-287853-cob7ur35	59	10	multiple	multiple	JJ
cord-287853-cob7ur35	59	11	exposed	expose	VBN
cord-287853-cob7ur35	59	12	epitopes	epitope	NNS
cord-287853-cob7ur35	59	13	and	and	CC
cord-287853-cob7ur35	59	14	are	be	VBP
cord-287853-cob7ur35	59	15	heterogeneously	heterogeneously	RB
cord-287853-cob7ur35	59	16	glycosylated	glycosylate	VBN
cord-287853-cob7ur35	59	17	molecules	molecule	NNS
cord-287853-cob7ur35	59	18	,	,	,
cord-287853-cob7ur35	59	19	with	with	IN
cord-287853-cob7ur35	59	20	more	more	JJR
cord-287853-cob7ur35	59	21	than	than	IN
cord-287853-cob7ur35	59	22	50	50	CD
cord-287853-cob7ur35	59	23	%	%	NN
cord-287853-cob7ur35	59	24	of	of	IN
cord-287853-cob7ur35	59	25	their	-PRON-	PRP$
cord-287853-cob7ur35	59	26	mass	mass	NN
cord-287853-cob7ur35	59	27	consisting	consisting	NN
cord-287853-cob7ur35	59	28	of	of	IN
cord-287853-cob7ur35	59	29	glycans	glycan	NNS
cord-287853-cob7ur35	59	30	(	(	-LRB-
cord-287853-cob7ur35	59	31	∼28	∼28	NNP
cord-287853-cob7ur35	59	32	N	N	NNP
cord-287853-cob7ur35	59	33	-	-	HYPH
cord-287853-cob7ur35	59	34	linked	link	VBN
cord-287853-cob7ur35	59	35	glycans	glycan	NNS
cord-287853-cob7ur35	59	36	)	)	-RRB-
cord-287853-cob7ur35	59	37	.	.	.
cord-287853-cob7ur35	60	1	It	-PRON-	PRP
cord-287853-cob7ur35	60	2	is	be	VBZ
cord-287853-cob7ur35	60	3	critically	critically	RB
cord-287853-cob7ur35	60	4	important	important	JJ
cord-287853-cob7ur35	60	5	to	to	TO
cord-287853-cob7ur35	60	6	monitor	monitor	VB
cord-287853-cob7ur35	60	7	this	this	DT
cord-287853-cob7ur35	60	8	HIV	HIV	NNP
cord-287853-cob7ur35	60	9	Env	Env	NNP
cord-287853-cob7ur35	60	10	glycan	glycan	NN
cord-287853-cob7ur35	60	11	shield	shield	NN
cord-287853-cob7ur35	60	12	during	during	IN
cord-287853-cob7ur35	60	13	vaccine	vaccine	NN
cord-287853-cob7ur35	60	14	development	development	NN
cord-287853-cob7ur35	60	15	.	.	.
cord-287853-cob7ur35	61	1	37	37	CD
cord-287853-cob7ur35	61	2	Crispin	Crispin	NNP
cord-287853-cob7ur35	61	3	and	and	CC
cord-287853-cob7ur35	61	4	collaborators	collaborator	NNS
cord-287853-cob7ur35	61	5	also	also	RB
cord-287853-cob7ur35	61	6	extensively	extensively	RB
cord-287853-cob7ur35	61	7	investigated	investigate	VBD
cord-287853-cob7ur35	61	8	the	the	DT
cord-287853-cob7ur35	61	9	native	native	JJ
cord-287853-cob7ur35	61	10	glycosylation	glycosylation	NN
cord-287853-cob7ur35	61	11	profile	profile	NN
cord-287853-cob7ur35	61	12	of	of	IN
cord-287853-cob7ur35	61	13	Envs	Envs	NNP
cord-287853-cob7ur35	61	14	,	,	,
cord-287853-cob7ur35	61	15	in	in	IN
cord-287853-cob7ur35	61	16	particularly	particularly	RB
cord-287853-cob7ur35	61	17	,	,	,
cord-287853-cob7ur35	61	18	trimeric	trimeric	JJ
cord-287853-cob7ur35	61	19	immunogen	immunogen	NN
cord-287853-cob7ur35	61	20	BG505	BG505	NNP
cord-287853-cob7ur35	61	21	SOSIP.664	SOSIP.664	NNP
cord-287853-cob7ur35	61	22	.	.	.
cord-287853-cob7ur35	62	1	[	[	-LRB-
cord-287853-cob7ur35	62	2	50	50	CD
cord-287853-cob7ur35	62	3	]	]	-RRB-
cord-287853-cob7ur35	62	4	[	[	-LRB-
cord-287853-cob7ur35	62	5	51	51	CD
cord-287853-cob7ur35	62	6	]	]	-RRB-
cord-287853-cob7ur35	62	7	[	[	-LRB-
cord-287853-cob7ur35	62	8	52	52	CD
cord-287853-cob7ur35	62	9	]	]	-RRB-
cord-287853-cob7ur35	63	1	[	[	-LRB-
cord-287853-cob7ur35	63	2	53	53	CD
cord-287853-cob7ur35	63	3	]	]	-RRB-
cord-287853-cob7ur35	64	1	Their	-PRON-	PRP$
cord-287853-cob7ur35	64	2	studies	study	NNS
cord-287853-cob7ur35	64	3	led	lead	VBD
cord-287853-cob7ur35	64	4	to	to	IN
cord-287853-cob7ur35	64	5	an	an	DT
cord-287853-cob7ur35	64	6	increased	increase	VBN
cord-287853-cob7ur35	64	7	understanding	understanding	NN
cord-287853-cob7ur35	64	8	of	of	IN
cord-287853-cob7ur35	64	9	the	the	DT
cord-287853-cob7ur35	64	10	glycan	glycan	NN
cord-287853-cob7ur35	64	11	shield	shield	NN
cord-287853-cob7ur35	64	12	of	of	IN
cord-287853-cob7ur35	64	13	the	the	DT
cord-287853-cob7ur35	64	14	Env	Env	NNP
cord-287853-cob7ur35	64	15	and	and	CC
cord-287853-cob7ur35	64	16	it	-PRON-	PRP
cord-287853-cob7ur35	64	17	is	be	VBZ
cord-287853-cob7ur35	64	18	now	now	RB
cord-287853-cob7ur35	64	19	largely	largely	RB
cord-287853-cob7ur35	64	20	accepted	accept	VBN
cord-287853-cob7ur35	64	21	that	that	IN
cord-287853-cob7ur35	64	22	to	to	TO
cord-287853-cob7ur35	64	23	induce	induce	VB
cord-287853-cob7ur35	64	24	bNAbs	bnabs	NN
cord-287853-cob7ur35	65	1	,	,	,
cord-287853-cob7ur35	65	2	the	the	DT
cord-287853-cob7ur35	65	3	HIV	HIV	NNP
cord-287853-cob7ur35	65	4	vaccine	vaccine	NN
cord-287853-cob7ur35	65	5	candidate	candidate	NN
cord-287853-cob7ur35	65	6	should	should	MD
cord-287853-cob7ur35	65	7	have	have	VB
cord-287853-cob7ur35	65	8	a	a	DT
cord-287853-cob7ur35	65	9	glycan	glycan	NN
cord-287853-cob7ur35	65	10	profile	profile	NN
cord-287853-cob7ur35	65	11	similar	similar	JJ
cord-287853-cob7ur35	65	12	to	to	IN
cord-287853-cob7ur35	65	13	the	the	DT
cord-287853-cob7ur35	65	14	one	one	CD
cord-287853-cob7ur35	65	15	present	present	NN
cord-287853-cob7ur35	65	16	on	on	IN
cord-287853-cob7ur35	65	17	the	the	DT
cord-287853-cob7ur35	65	18	native	native	JJ
cord-287853-cob7ur35	65	19	Env	Env	NNP
cord-287853-cob7ur35	65	20	trimers	trimer	NNS
cord-287853-cob7ur35	65	21	.	.	.
cord-287853-cob7ur35	66	1	[	[	-LRB-
cord-287853-cob7ur35	66	2	54	54	CD
cord-287853-cob7ur35	66	3	]	]	-RRB-
cord-287853-cob7ur35	66	4	[	[	-LRB-
cord-287853-cob7ur35	66	5	55	55	CD
cord-287853-cob7ur35	66	6	]	]	-RRB-
cord-287853-cob7ur35	67	1	[	[	-LRB-
cord-287853-cob7ur35	67	2	56	56	CD
cord-287853-cob7ur35	67	3	]	]	-RRB-
cord-287853-cob7ur35	68	1	In	in	IN
cord-287853-cob7ur35	68	2	a	a	DT
cord-287853-cob7ur35	68	3	thorough	thorough	JJ
cord-287853-cob7ur35	68	4	study	study	NN
cord-287853-cob7ur35	68	5	on	on	IN
cord-287853-cob7ur35	68	6	trimeric	trimeric	NNP
cord-287853-cob7ur35	68	7	Env	Env	NNP
cord-287853-cob7ur35	68	8	glycosylation	glycosylation	NN
cord-287853-cob7ur35	68	9	,	,	,
cord-287853-cob7ur35	68	10	Behrens	Behrens	NNP
cord-287853-cob7ur35	68	11	et	et	NNP
cord-287853-cob7ur35	68	12	al	al	NNP
cord-287853-cob7ur35	68	13	51	51	CD
cord-287853-cob7ur35	68	14	 	 	_SP
cord-287853-cob7ur35	69	1	Influenza	influenza	NN
cord-287853-cob7ur35	69	2	virus	virus	NN
cord-287853-cob7ur35	69	3	is	be	VBZ
cord-287853-cob7ur35	69	4	a	a	DT
cord-287853-cob7ur35	69	5	segmented	segmented	JJ
cord-287853-cob7ur35	69	6	,	,	,
cord-287853-cob7ur35	69	7	enveloped	envelop	VBN
cord-287853-cob7ur35	69	8	RNA	RNA	NNP
cord-287853-cob7ur35	69	9	virus	virus	NN
cord-287853-cob7ur35	69	10	and	and	CC
cord-287853-cob7ur35	69	11	is	be	VBZ
cord-287853-cob7ur35	69	12	among	among	IN
cord-287853-cob7ur35	69	13	the	the	DT
cord-287853-cob7ur35	69	14	IC	IC	NNP
cord-287853-cob7ur35	69	15	-	-	HYPH
cord-287853-cob7ur35	69	16	IDMS	IDMS	NNP
cord-287853-cob7ur35	69	17	-	-	HYPH
cord-287853-cob7ur35	69	18	MRM	MRM	NNP
cord-287853-cob7ur35	69	19	method	method	NN
cord-287853-cob7ur35	69	20	is	be	VBZ
cord-287853-cob7ur35	69	21	truly	truly	RB
cord-287853-cob7ur35	69	22	an	an	DT
cord-287853-cob7ur35	69	23	alternative	alternative	NN
cord-287853-cob7ur35	69	24	to	to	IN
cord-287853-cob7ur35	69	25	the	the	DT
cord-287853-cob7ur35	69	26	approved	approve	VBN
cord-287853-cob7ur35	69	27	SRID	SRID	NNP
cord-287853-cob7ur35	69	28	method	method	NN
cord-287853-cob7ur35	69	29	as	as	IN
cord-287853-cob7ur35	69	30	it	-PRON-	PRP
cord-287853-cob7ur35	69	31	has	have	VBZ
cord-287853-cob7ur35	69	32	dual	dual	JJ
cord-287853-cob7ur35	69	33	purpose	purpose	NN
cord-287853-cob7ur35	69	34	"	"	``
cord-287853-cob7ur35	69	35	potency	potency	NN
cord-287853-cob7ur35	69	36	and	and	CC
cord-287853-cob7ur35	69	37	content	content	NN
cord-287853-cob7ur35	69	38	determination	determination	NN
cord-287853-cob7ur35	69	39	"	"	''
cord-287853-cob7ur35	69	40	,	,	,
cord-287853-cob7ur35	69	41	was	be	VBD
cord-287853-cob7ur35	69	42	found	find	VBN
cord-287853-cob7ur35	69	43	to	to	TO
cord-287853-cob7ur35	69	44	be	be	VB
cord-287853-cob7ur35	69	45	equivalent	equivalent	JJ
cord-287853-cob7ur35	69	46	to	to	IN
cord-287853-cob7ur35	69	47	the	the	DT
cord-287853-cob7ur35	69	48	SRID	SRID	NNP
cord-287853-cob7ur35	69	49	method	method	NN
cord-287853-cob7ur35	69	50	and	and	CC
cord-287853-cob7ur35	69	51	can	can	MD
cord-287853-cob7ur35	69	52	also	also	RB
cord-287853-cob7ur35	69	53	be	be	VB
cord-287853-cob7ur35	69	54	used	use	VBN
cord-287853-cob7ur35	69	55	in	in	IN
cord-287853-cob7ur35	69	56	response	response	NN
cord-287853-cob7ur35	69	57	to	to	IN
cord-287853-cob7ur35	69	58	a	a	DT
cord-287853-cob7ur35	69	59	pandemic	pandemic	NN
cord-287853-cob7ur35	69	60	influenza	influenza	NN
cord-287853-cob7ur35	69	61	threat	threat	NN
cord-287853-cob7ur35	69	62	.	.	.
cord-287853-cob7ur35	70	1	75	75	CD
cord-287853-cob7ur35	70	2	,	,	,
cord-287853-cob7ur35	70	3	76	76	CD
cord-287853-cob7ur35	70	4	Additionally	additionally	RB
cord-287853-cob7ur35	70	5	,	,	,
cord-287853-cob7ur35	70	6	a	a	DT
cord-287853-cob7ur35	70	7	direct	direct	JJ
cord-287853-cob7ur35	70	8	Ultra	Ultra	NNP
cord-287853-cob7ur35	70	9	-	-	HYPH
cord-287853-cob7ur35	70	10	Performance	Performance	NNP
cord-287853-cob7ur35	70	11	Liquid	Liquid	NNP
cord-287853-cob7ur35	70	12	Chromatography	Chromatography	NNP
cord-287853-cob7ur35	70	13	(	(	-LRB-
cord-287853-cob7ur35	70	14	UPLC)-IDMS	UPLC)-IDMS	NNP
cord-287853-cob7ur35	70	15	method	method	NN
cord-287853-cob7ur35	70	16	was	be	VBD
cord-287853-cob7ur35	70	17	reported	report	VBN
cord-287853-cob7ur35	70	18	for	for	IN
cord-287853-cob7ur35	70	19	the	the	DT
cord-287853-cob7ur35	70	20	rapid	rapid	JJ
cord-287853-cob7ur35	70	21	and	and	CC
cord-287853-cob7ur35	70	22	accurate	accurate	JJ
cord-287853-cob7ur35	70	23	quantification	quantification	NN
cord-287853-cob7ur35	70	24	of	of	IN
cord-287853-cob7ur35	70	25	influenza	influenza	NN
cord-287853-cob7ur35	70	26	NA	NA	NNP
cord-287853-cob7ur35	70	27	.	.	.
cord-287853-cob7ur35	71	1	77	77	CD
cord-287853-cob7ur35	71	2	Label	label	NN
cord-287853-cob7ur35	71	3	-	-	HYPH
cord-287853-cob7ur35	71	4	free	free	JJ
cord-287853-cob7ur35	71	5	MS	MS	NNP
cord-287853-cob7ur35	71	6	-	-	HYPH
cord-287853-cob7ur35	71	7	based	base	VBN
cord-287853-cob7ur35	71	8	methods	method	NNS
cord-287853-cob7ur35	71	9	have	have	VBP
cord-287853-cob7ur35	71	10	also	also	RB
cord-287853-cob7ur35	71	11	been	be	VBN
cord-287853-cob7ur35	71	12	reported	report	VBN
cord-287853-cob7ur35	71	13	for	for	IN
cord-287853-cob7ur35	71	14	the	the	DT
cord-287853-cob7ur35	71	15	simultaneous	simultaneous	JJ
cord-287853-cob7ur35	71	16	identification	identification	NN
cord-287853-cob7ur35	71	17	and	and	CC
cord-287853-cob7ur35	71	18	quantification	quantification	NN
cord-287853-cob7ur35	71	19	of	of	IN
cord-287853-cob7ur35	71	20	HA	HA	NNP
cord-287853-cob7ur35	71	21	and	and	CC
cord-287853-cob7ur35	71	22	NA	NA	NNP
cord-287853-cob7ur35	71	23	in	in	IN
cord-287853-cob7ur35	71	24	influenza	influenza	JJ
cord-287853-cob7ur35	71	25	vaccine	vaccine	NN
cord-287853-cob7ur35	71	26	with	with	IN
cord-287853-cob7ur35	71	27	samples	sample	NNS
cord-287853-cob7ur35	71	28	analyzed	analyze	VBN
cord-287853-cob7ur35	71	29	by	by	IN
cord-287853-cob7ur35	71	30	LC	LC	NNP
cord-287853-cob7ur35	71	31	-	-	HYPH
cord-287853-cob7ur35	71	32	MS	MS	NNP
cord-287853-cob7ur35	71	33	E	E	NNP
cord-287853-cob7ur35	71	34	on	on	IN
cord-287853-cob7ur35	71	35	a	a	DT
cord-287853-cob7ur35	71	36	Waters	water	NNS
cord-287853-cob7ur35	72	1	Synapt	Synapt	NNP
cord-287853-cob7ur35	72	2	G2	G2	NNP
cord-287853-cob7ur35	72	3	mass	mass	NN
cord-287853-cob7ur35	72	4	spectrometer	spectrometer	NN
cord-287853-cob7ur35	72	5	.	.	.
cord-287853-cob7ur35	73	1	78	78	CD
cord-287853-cob7ur35	73	2	Quantification	quantification	NN
cord-287853-cob7ur35	73	3	of	of	IN
cord-287853-cob7ur35	73	4	proteins	protein	NNS
cord-287853-cob7ur35	73	5	by	by	IN
cord-287853-cob7ur35	73	6	labelfree	labelfree	NNP
cord-287853-cob7ur35	73	7	LC	LC	NNP
cord-287853-cob7ur35	73	8	-	-	HYPH
cord-287853-cob7ur35	73	9	MS	MS	NNP
cord-287853-cob7ur35	73	10	E	E	NNP
cord-287853-cob7ur35	73	11	is	be	VBZ
cord-287853-cob7ur35	73	12	a	a	DT
cord-287853-cob7ur35	73	13	powerful	powerful	JJ
cord-287853-cob7ur35	73	14	tool	tool	NN
cord-287853-cob7ur35	73	15	,	,	,
cord-287853-cob7ur35	73	16	in	in	IN
cord-287853-cob7ur35	73	17	this	this	DT
cord-287853-cob7ur35	73	18	method	method	NN
cord-287853-cob7ur35	73	19	,	,	,
cord-287853-cob7ur35	73	20	alternating	alternate	VBG
cord-287853-cob7ur35	73	21	scans	scan	NNS
cord-287853-cob7ur35	73	22	of	of	IN
cord-287853-cob7ur35	73	23	low	low	JJ
cord-287853-cob7ur35	73	24	collision	collision	NN
cord-287853-cob7ur35	73	25	energy	energy	NN
cord-287853-cob7ur35	73	26	and	and	CC
cord-287853-cob7ur35	73	27	elevated	elevated	JJ
cord-287853-cob7ur35	73	28	collision	collision	NN
cord-287853-cob7ur35	73	29	energy	energy	NN
cord-287853-cob7ur35	73	30	during	during	IN
cord-287853-cob7ur35	73	31	LC	LC	NNP
cord-287853-cob7ur35	73	32	-	-	HYPH
cord-287853-cob7ur35	73	33	MS	MS	NNP
cord-287853-cob7ur35	73	34	analysis	analysis	NN
cord-287853-cob7ur35	73	35	to	to	TO
cord-287853-cob7ur35	73	36	obtain	obtain	VB
cord-287853-cob7ur35	73	37	both	both	DT
cord-287853-cob7ur35	73	38	protein	protein	NN
cord-287853-cob7ur35	73	39	identity	identity	NN
cord-287853-cob7ur35	73	40	and	and	CC
cord-287853-cob7ur35	73	41	quantity	quantity	NN
cord-287853-cob7ur35	73	42	in	in	IN
cord-287853-cob7ur35	73	43	a	a	DT
cord-287853-cob7ur35	73	44	single	single	JJ
cord-287853-cob7ur35	73	45	experiment	experiment	NN
cord-287853-cob7ur35	73	46	.	.	.
cord-287853-cob7ur35	74	1	Quantification	quantification	NN
cord-287853-cob7ur35	74	2	based	base	VBN
cord-287853-cob7ur35	74	3	on	on	IN
cord-287853-cob7ur35	74	4	the	the	DT
cord-287853-cob7ur35	74	5	experimental	experimental	JJ
cord-287853-cob7ur35	74	6	data	datum	NNS
cord-287853-cob7ur35	74	7	showed	show	VBD
cord-287853-cob7ur35	74	8	that	that	IN
cord-287853-cob7ur35	74	9	the	the	DT
cord-287853-cob7ur35	74	10	signal	signal	JJ
cord-287853-cob7ur35	74	11	intensity	intensity	NN
cord-287853-cob7ur35	74	12	was	be	VBD
cord-287853-cob7ur35	74	13	proportional	proportional	JJ
cord-287853-cob7ur35	74	14	to	to	IN
cord-287853-cob7ur35	74	15	concentration	concentration	NN
cord-287853-cob7ur35	74	16	which	which	WDT
cord-287853-cob7ur35	74	17	allowed	allow	VBD
cord-287853-cob7ur35	74	18	for	for	IN
cord-287853-cob7ur35	74	19	the	the	DT
cord-287853-cob7ur35	74	20	amount	amount	NN
cord-287853-cob7ur35	74	21	of	of	IN
cord-287853-cob7ur35	74	22	any	any	DT
cord-287853-cob7ur35	74	23	protein	protein	NN
cord-287853-cob7ur35	74	24	in	in	IN
cord-287853-cob7ur35	74	25	the	the	DT
cord-287853-cob7ur35	74	26	mixture	mixture	NN
cord-287853-cob7ur35	74	27	to	to	TO
cord-287853-cob7ur35	74	28	be	be	VB
cord-287853-cob7ur35	74	29	estimated	estimate	VBN
cord-287853-cob7ur35	74	30	.	.	.
cord-287853-cob7ur35	75	1	LC	LC	NNP
cord-287853-cob7ur35	75	2	-	-	HYPH
cord-287853-cob7ur35	75	3	MS	MS	NNP
cord-287853-cob7ur35	75	4	E	E	NNP
cord-287853-cob7ur35	75	5	utilizes	utilize	VBZ
cord-287853-cob7ur35	75	6	parallel	parallel	JJ
cord-287853-cob7ur35	75	7	,	,	,
cord-287853-cob7ur35	75	8	multiplex	multiplex	JJ
cord-287853-cob7ur35	75	9	fragmentation	fragmentation	NN
cord-287853-cob7ur35	75	10	where	where	WRB
cord-287853-cob7ur35	75	11	all	all	DT
cord-287853-cob7ur35	75	12	peptide	peptide	JJ
cord-287853-cob7ur35	75	13	precursors	precursor	NNS
cord-287853-cob7ur35	75	14	are	be	VBP
cord-287853-cob7ur35	75	15	simultaneously	simultaneously	RB
cord-287853-cob7ur35	75	16	fragmented	fragment	VBN
cord-287853-cob7ur35	75	17	throughout	throughout	IN
cord-287853-cob7ur35	75	18	the	the	DT
cord-287853-cob7ur35	75	19	chromatographic	chromatographic	JJ
cord-287853-cob7ur35	75	20	The	the	DT
cord-287853-cob7ur35	75	21	SRID	SRID	NNP
cord-287853-cob7ur35	75	22	assay	assay	NN
cord-287853-cob7ur35	75	23	has	have	VBZ
cord-287853-cob7ur35	75	24	been	be	VBN
cord-287853-cob7ur35	75	25	used	use	VBN
cord-287853-cob7ur35	75	26	for	for	IN
cord-287853-cob7ur35	75	27	over	over	IN
cord-287853-cob7ur35	75	28	40	40	CD
cord-287853-cob7ur35	75	29	years	year	NNS
cord-287853-cob7ur35	75	30	as	as	IN
cord-287853-cob7ur35	75	31	a	a	DT
cord-287853-cob7ur35	75	32	quantitative	quantitative	JJ
cord-287853-cob7ur35	75	33	and	and	CC
cord-287853-cob7ur35	75	34	potency	potency	NN
cord-287853-cob7ur35	75	35	method	method	NN
cord-287853-cob7ur35	75	36	throughout	throughout	IN
cord-287853-cob7ur35	75	37	the	the	DT
cord-287853-cob7ur35	75	38	world	world	NN
cord-287853-cob7ur35	75	39	despite	despite	IN
cord-287853-cob7ur35	75	40	issues	issue	NNS
cord-287853-cob7ur35	75	41	regarding	regard	VBG
cord-287853-cob7ur35	75	42	variability	variability	NN
cord-287853-cob7ur35	75	43	and	and	CC
cord-287853-cob7ur35	75	44	availability	availability	NN
cord-287853-cob7ur35	75	45	of	of	IN
cord-287853-cob7ur35	75	46	standard	standard	JJ
cord-287853-cob7ur35	75	47	reagents	reagent	NNS
cord-287853-cob7ur35	75	48	.	.	.
cord-287853-cob7ur35	76	1	Thus	thus	RB
cord-287853-cob7ur35	76	2	,	,	,
cord-287853-cob7ur35	76	3	even	even	RB
cord-287853-cob7ur35	76	4	though	though	IN
cord-287853-cob7ur35	76	5	new	new	JJ
cord-287853-cob7ur35	76	6	methods	method	NNS
cord-287853-cob7ur35	76	7	like	like	IN
cord-287853-cob7ur35	76	8	HPLC	HPLC	NNP
cord-287853-cob7ur35	76	9	and	and	CC
cord-287853-cob7ur35	76	10	mass	mass	NN
cord-287853-cob7ur35	76	11	spectrometry	spectrometry	NN
cord-287853-cob7ur35	76	12	are	be	VBP
cord-287853-cob7ur35	76	13	being	be	VBG
cord-287853-cob7ur35	76	14	developed	develop	VBN
cord-287853-cob7ur35	76	15	,	,	,
cord-287853-cob7ur35	76	16	it	-PRON-	PRP
cord-287853-cob7ur35	76	17	will	will	MD
cord-287853-cob7ur35	76	18	take	take	VB
cord-287853-cob7ur35	76	19	some	some	DT
cord-287853-cob7ur35	76	20	time	time	NN
cord-287853-cob7ur35	76	21	for	for	IN
cord-287853-cob7ur35	76	22	these	these	DT
cord-287853-cob7ur35	76	23	methods	method	NNS
cord-287853-cob7ur35	76	24	to	to	TO
cord-287853-cob7ur35	76	25	be	be	VB
cord-287853-cob7ur35	76	26	adopted	adopt	VBN
cord-287853-cob7ur35	76	27	worldwide	worldwide	RB
cord-287853-cob7ur35	76	28	.	.	.
cord-287853-cob7ur35	77	1	As	as	IN
cord-287853-cob7ur35	77	2	the	the	DT
cord-287853-cob7ur35	77	3	next	next	JJ
cord-287853-cob7ur35	77	4	influenza	influenza	NN
cord-287853-cob7ur35	77	5	pandemic	pandemic	NN
cord-287853-cob7ur35	77	6	can	can	MD
cord-287853-cob7ur35	77	7	not	not	RB
cord-287853-cob7ur35	77	8	be	be	VB
cord-287853-cob7ur35	77	9	predicted	predict	VBN
cord-287853-cob7ur35	77	10	,	,	,
cord-287853-cob7ur35	77	11	the	the	DT
cord-287853-cob7ur35	77	12	health	health	NN
cord-287853-cob7ur35	77	13	authorities	authority	NNS
cord-287853-cob7ur35	77	14	'	'	POS
cord-287853-cob7ur35	77	15	pandemic	pandemic	NN
cord-287853-cob7ur35	77	16	preparedness	preparedness	NN
cord-287853-cob7ur35	77	17	efforts	effort	NNS
cord-287853-cob7ur35	77	18	include	include	VBP
cord-287853-cob7ur35	77	19	efforts	effort	NNS
cord-287853-cob7ur35	77	20	to	to	TO
cord-287853-cob7ur35	77	21	ensure	ensure	VB
cord-287853-cob7ur35	77	22	expedited	expedited	JJ
cord-287853-cob7ur35	77	23	availability	availability	NN
cord-287853-cob7ur35	77	24	of	of	IN
cord-287853-cob7ur35	77	25	pandemic	pandemic	JJ
cord-287853-cob7ur35	77	26	vaccines	vaccine	NNS
cord-287853-cob7ur35	77	27	.	.	.
cord-287853-cob7ur35	78	1	Methods	method	NNS
cord-287853-cob7ur35	78	2	such	such	JJ
cord-287853-cob7ur35	78	3	as	as	IN
cord-287853-cob7ur35	78	4	HPLC	HPLC	NNP
cord-287853-cob7ur35	78	5	and	and	CC
cord-287853-cob7ur35	78	6	MS	MS	NNP
cord-287853-cob7ur35	78	7	,	,	,
cord-287853-cob7ur35	78	8	with	with	IN
cord-287853-cob7ur35	78	9	their	-PRON-	PRP$
cord-287853-cob7ur35	78	10	ability	ability	NN
cord-287853-cob7ur35	78	11	to	to	TO
cord-287853-cob7ur35	78	12	quantitate	quantitate	VB
cord-287853-cob7ur35	78	13	antigens	antigen	NNS
cord-287853-cob7ur35	78	14	without	without	IN
cord-287853-cob7ur35	78	15	standard	standard	JJ
cord-287853-cob7ur35	78	16	reference	reference	NN
cord-287853-cob7ur35	78	17	reagents	reagent	NNS
cord-287853-cob7ur35	78	18	,	,	,
cord-287853-cob7ur35	78	19	can	can	MD
cord-287853-cob7ur35	78	20	become	become	VB
cord-287853-cob7ur35	78	21	a	a	DT
cord-287853-cob7ur35	78	22	cornerstone	cornerstone	NN
cord-287853-cob7ur35	78	23	of	of	IN
cord-287853-cob7ur35	78	24	pandemic	pandemic	NNP
cord-287853-cob7ur35	78	25	influenza	influenza	NN
cord-287853-cob7ur35	78	26	preparedness	preparedness	NN
cord-287853-cob7ur35	78	27	.	.	.
cord-287853-cob7ur35	79	1	The	the	DT
cord-287853-cob7ur35	79	2	viral	viral	JJ
cord-287853-cob7ur35	79	3	genus	genus	NN
cord-287853-cob7ur35	79	4	Flavivirus	Flavivirus	NNP
cord-287853-cob7ur35	79	5	,	,	,
cord-287853-cob7ur35	79	6	includes	include	VBZ
cord-287853-cob7ur35	79	7	Dengue	dengue	NN
cord-287853-cob7ur35	79	8	virus	virus	NN
cord-287853-cob7ur35	79	9	,	,	,
cord-287853-cob7ur35	79	10	yellow	yellow	JJ
cord-287853-cob7ur35	79	11	fever	fever	NN
cord-287853-cob7ur35	79	12	virus	virus	NN
cord-287853-cob7ur35	79	13	,	,	,
cord-287853-cob7ur35	79	14	and	and	CC
cord-287853-cob7ur35	79	15	and	and	CC
cord-287853-cob7ur35	79	16	153	153	CD
cord-287853-cob7ur35	79	17	were	be	VBD
cord-287853-cob7ur35	79	18	glycosylated	glycosylate	VBN
cord-287853-cob7ur35	79	19	and	and	CC
cord-287853-cob7ur35	79	20	,	,	,
cord-287853-cob7ur35	79	21	predominately	predominately	RB
cord-287853-cob7ur35	79	22	,	,	,
cord-287853-cob7ur35	79	23	the	the	DT
cord-287853-cob7ur35	79	24	N	n	CD
cord-287853-cob7ur35	79	25	-	-	HYPH
cord-287853-cob7ur35	79	26	glycan	glycan	NN
cord-287853-cob7ur35	79	27	at	at	IN
cord-287853-cob7ur35	79	28	Asn67	Asn67	NNPS
cord-287853-cob7ur35	79	29	was	be	VBD
cord-287853-cob7ur35	79	30	a	a	DT
cord-287853-cob7ur35	79	31	high	high	JJ
cord-287853-cob7ur35	79	32	mannose	mannose	NN
cord-287853-cob7ur35	79	33	-	-	HYPH
cord-287853-cob7ur35	79	34	type	type	NN
cord-287853-cob7ur35	79	35	and	and	CC
cord-287853-cob7ur35	80	1	at	at	IN
cord-287853-cob7ur35	80	2	Asn153	asn153	CD
cord-287853-cob7ur35	80	3	was	be	VBD
cord-287853-cob7ur35	80	4	mainly	mainly	RB
cord-287853-cob7ur35	80	5	a	a	DT
cord-287853-cob7ur35	80	6	combination	combination	NN
cord-287853-cob7ur35	80	7	of	of	IN
cord-287853-cob7ur35	80	8	complex	complex	JJ
cord-287853-cob7ur35	80	9	-	-	HYPH
cord-287853-cob7ur35	80	10	and	and	CC
cord-287853-cob7ur35	80	11	hybrid	hybrid	JJ
cord-287853-cob7ur35	80	12	-	-	HYPH
cord-287853-cob7ur35	80	13	type	type	NN
cord-287853-cob7ur35	80	14	glycans	glycan	NNS
cord-287853-cob7ur35	80	15	.	.	.
cord-287853-cob7ur35	81	1	87	87	CD
cord-287853-cob7ur35	82	1	This	this	DT
cord-287853-cob7ur35	82	2	study	study	NN
cord-287853-cob7ur35	82	3	provided	provide	VBD
cord-287853-cob7ur35	82	4	important	important	JJ
cord-287853-cob7ur35	82	5	new	new	JJ
cord-287853-cob7ur35	82	6	insights	insight	NNS
cord-287853-cob7ur35	82	7	for	for	IN
cord-287853-cob7ur35	82	8	the	the	DT
cord-287853-cob7ur35	82	9	role	role	NN
cord-287853-cob7ur35	82	10	of	of	IN
cord-287853-cob7ur35	82	11	glycans	glycan	NNS
cord-287853-cob7ur35	82	12	in	in	IN
cord-287853-cob7ur35	82	13	the	the	DT
cord-287853-cob7ur35	82	14	dengue	dengue	NN
cord-287853-cob7ur35	82	15	virus	virus	NN
cord-287853-cob7ur35	82	16	-	-	HYPH
cord-287853-cob7ur35	82	17	host	host	NN
cord-287853-cob7ur35	82	18	cell	cell	NN
cord-287853-cob7ur35	82	19	interactions	interaction	NNS
cord-287853-cob7ur35	82	20	.	.	.
cord-287853-cob7ur35	83	1	In	in	IN
cord-287853-cob7ur35	83	2	a	a	DT
cord-287853-cob7ur35	83	3	separate	separate	JJ
cord-287853-cob7ur35	83	4	study	study	NN
cord-287853-cob7ur35	83	5	,	,	,
cord-287853-cob7ur35	83	6	accurate	accurate	JJ
cord-287853-cob7ur35	83	7	quantitation	quantitation	NN
cord-287853-cob7ur35	83	8	of	of	IN
cord-287853-cob7ur35	83	9	the	the	DT
cord-287853-cob7ur35	83	10	expressed	express	VBN
cord-287853-cob7ur35	83	11	four	four	CD
cord-287853-cob7ur35	83	12	viral	viral	JJ
cord-287853-cob7ur35	83	13	particles	particle	NNS
cord-287853-cob7ur35	83	14	in	in	IN
cord-287853-cob7ur35	83	15	the	the	DT
cord-287853-cob7ur35	83	16	tetravalent	tetravalent	NN
cord-287853-cob7ur35	83	17	dengue	dengue	NN
cord-287853-cob7ur35	83	18	vaccine	vaccine	NN
cord-287853-cob7ur35	83	19	(	(	-LRB-
cord-287853-cob7ur35	83	20	CYD	cyd	NN
cord-287853-cob7ur35	83	21	)	)	-RRB-
cord-287853-cob7ur35	83	22	was	be	VBD
cord-287853-cob7ur35	83	23	performed	perform	VBN
cord-287853-cob7ur35	83	24	using	use	VBG
cord-287853-cob7ur35	83	25	targeted	target	VBN
cord-287853-cob7ur35	83	26	MS	MS	NNP
cord-287853-cob7ur35	83	27	in	in	IN
cord-287853-cob7ur35	83	28	selected	select	VBN
cord-287853-cob7ur35	83	29	reaction	reaction	NN
cord-287853-cob7ur35	83	30	monitoring	monitoring	NN
cord-287853-cob7ur35	83	31	(	(	-LRB-
cord-287853-cob7ur35	83	32	SRM	SRM	NNP
cord-287853-cob7ur35	83	33	)	)	-RRB-
cord-287853-cob7ur35	83	34	mode	mode	NN
cord-287853-cob7ur35	83	35	.	.	.
cord-287853-cob7ur35	84	1	88	88	CD
cord-287853-cob7ur35	85	1	The	the	DT
cord-287853-cob7ur35	85	2	study	study	NN
cord-287853-cob7ur35	85	3	described	describe	VBD
cord-287853-cob7ur35	85	4	an	an	DT
cord-287853-cob7ur35	85	5	orthogonal	orthogonal	JJ
cord-287853-cob7ur35	85	6	quantitation	quantitation	NN
cord-287853-cob7ur35	85	7	strategy	strategy	NN
cord-287853-cob7ur35	85	8	(	(	-LRB-
cord-287853-cob7ur35	85	9	targeted	target	VBN
cord-287853-cob7ur35	85	10	MS	MS	NNP
cord-287853-cob7ur35	85	11	in	in	IN
cord-287853-cob7ur35	85	12	SRM	SRM	NNP
cord-287853-cob7ur35	85	13	mode	mode	NN
cord-287853-cob7ur35	85	14	)	)	-RRB-
cord-287853-cob7ur35	85	15	and	and	CC
cord-287853-cob7ur35	85	16	demonstrated	demonstrate	VBD
cord-287853-cob7ur35	85	17	that	that	IN
cord-287853-cob7ur35	85	18	the	the	DT
cord-287853-cob7ur35	85	19	variability	variability	NN
cord-287853-cob7ur35	85	20	of	of	IN
cord-287853-cob7ur35	85	21	the	the	DT
cord-287853-cob7ur35	85	22	MS	MS	NNP
cord-287853-cob7ur35	85	23	method	method	NN
cord-287853-cob7ur35	85	24	was	be	VBD
cord-287853-cob7ur35	85	25	low	low	JJ
cord-287853-cob7ur35	85	26	(	(	-LRB-
cord-287853-cob7ur35	85	27	between	between	IN
cord-287853-cob7ur35	85	28	8	8	CD
cord-287853-cob7ur35	85	29	%	%	NN
cord-287853-cob7ur35	85	30	and	and	CC
cord-287853-cob7ur35	85	31	17	17	CD
cord-287853-cob7ur35	85	32	%	%	NN
cord-287853-cob7ur35	85	33	)	)	-RRB-
cord-287853-cob7ur35	85	34	and	and	CC
cord-287853-cob7ur35	85	35	the	the	DT
cord-287853-cob7ur35	85	36	assay	assay	NN
cord-287853-cob7ur35	85	37	was	be	VBD
cord-287853-cob7ur35	85	38	linear	linear	JJ
cord-287853-cob7ur35	85	39	between	between	IN
cord-287853-cob7ur35	85	40	6.25	6.25	CD
cord-287853-cob7ur35	85	41	and	and	CC
cord-287853-cob7ur35	85	42	200	200	CD
cord-287853-cob7ur35	86	1	nmol	nmol	NNP
cord-287853-cob7ur35	86	2	/	/	SYM
cord-287853-cob7ur35	86	3	L.	L.	NNP
cord-287853-cob7ur35	86	4	Based	Based	NNP
cord-287853-cob7ur35	86	5	on	on	IN
cord-287853-cob7ur35	86	6	the	the	DT
cord-287853-cob7ur35	86	7	reported	report	VBN
cord-287853-cob7ur35	86	8	method	method	NN
cord-287853-cob7ur35	86	9	performance	performance	NN
cord-287853-cob7ur35	86	10	,	,	,
cord-287853-cob7ur35	86	11	it	-PRON-	PRP
cord-287853-cob7ur35	86	12	could	could	MD
cord-287853-cob7ur35	86	13	be	be	VB
cord-287853-cob7ur35	86	14	used	use	VBN
cord-287853-cob7ur35	86	15	to	to	TO
cord-287853-cob7ur35	86	16	release	release	VB
cord-287853-cob7ur35	86	17	future	future	JJ
cord-287853-cob7ur35	86	18	batches	batch	NNS
cord-287853-cob7ur35	86	19	of	of	IN
cord-287853-cob7ur35	86	20	the	the	DT
cord-287853-cob7ur35	86	21	tetravalent	tetravalent	NN
cord-287853-cob7ur35	86	22	dengue	dengue	NN
cord-287853-cob7ur35	86	23	vaccine	vaccine	NN
cord-287853-cob7ur35	86	24	.	.	.
cord-287853-cob7ur35	87	1	Ebola	Ebola	NNP
cord-287853-cob7ur35	88	1	The	the	DT
cord-287853-cob7ur35	88	2	data	datum	NNS
cord-287853-cob7ur35	88	3	presented	present	VBD
cord-287853-cob7ur35	88	4	demonstrated	demonstrate	VBD
cord-287853-cob7ur35	88	5	that	that	IN
cord-287853-cob7ur35	88	6	the	the	DT
cord-287853-cob7ur35	88	7	N	n	CD
cord-287853-cob7ur35	88	8	-	-	HYPH
cord-287853-cob7ur35	88	9	glycan	glycan	NN
cord-287853-cob7ur35	88	10	patterns	pattern	NNS
cord-287853-cob7ur35	88	11	were	be	VBD
cord-287853-cob7ur35	88	12	similar	similar	JJ
cord-287853-cob7ur35	88	13	between	between	IN
cord-287853-cob7ur35	88	14	GP	GP	NNP
cord-287853-cob7ur35	88	15	1,2	1,2	CD
cord-287853-cob7ur35	88	16	but	but	CC
cord-287853-cob7ur35	89	1	O	o	NN
cord-287853-cob7ur35	89	2	-	-	HYPH
cord-287853-cob7ur35	89	3	glycan	glycan	NN
cord-287853-cob7ur35	89	4	patterns	pattern	NNS
cord-287853-cob7ur35	89	5	were	be	VBD
cord-287853-cob7ur35	89	6	remarkably	remarkably	RB
cord-287853-cob7ur35	89	7	different	different	JJ
cord-287853-cob7ur35	89	8	on	on	IN
cord-287853-cob7ur35	89	9	GP	GP	NNP
cord-287853-cob7ur35	89	10	1,2	1,2	CD
cord-287853-cob7ur35	90	1	the	the	DT
cord-287853-cob7ur35	90	2	five	five	CD
cord-287853-cob7ur35	90	3	Ebola	Ebola	NNP
cord-287853-cob7ur35	90	4	viruses	virus	NNS
cord-287853-cob7ur35	90	5	.	.	.
cord-287853-cob7ur35	91	1	This	this	DT
cord-287853-cob7ur35	91	2	study	study	NN
cord-287853-cob7ur35	91	3	should	should	MD
cord-287853-cob7ur35	91	4	serve	serve	VB
cord-287853-cob7ur35	91	5	as	as	IN
cord-287853-cob7ur35	91	6	the	the	DT
cord-287853-cob7ur35	91	7	foundation	foundation	NN
cord-287853-cob7ur35	91	8	for	for	IN
cord-287853-cob7ur35	91	9	future	future	JJ
cord-287853-cob7ur35	91	10	Ebola	Ebola	NNP
cord-287853-cob7ur35	91	11	viral	viral	JJ
cord-287853-cob7ur35	91	12	entry	entry	NN
cord-287853-cob7ur35	91	13	and	and	CC
cord-287853-cob7ur35	91	14	immunogenicity	immunogenicity	NN
cord-287853-cob7ur35	91	15	studies	study	NNS
cord-287853-cob7ur35	91	16	.	.	.
cord-287853-cob7ur35	92	1	91	91	CD
cord-287853-cob7ur35	93	1	To	to	TO
cord-287853-cob7ur35	93	2	improve	improve	VB
cord-287853-cob7ur35	93	3	on	on	IN
cord-287853-cob7ur35	93	4	the	the	DT
cord-287853-cob7ur35	93	5	conventional	conventional	JJ
cord-287853-cob7ur35	93	6	approaches	approach	NNS
cord-287853-cob7ur35	93	7	for	for	IN
cord-287853-cob7ur35	93	8	absolute	absolute	JJ
cord-287853-cob7ur35	93	9	quantitation	quantitation	NN
cord-287853-cob7ur35	93	10	of	of	IN
cord-287853-cob7ur35	93	11	GP1	gp1	NN
cord-287853-cob7ur35	93	12	in	in	IN
cord-287853-cob7ur35	93	13	Ebola	Ebola	NNP
cord-287853-cob7ur35	93	14	virus	virus	NN
cord-287853-cob7ur35	93	15	-	-	HYPH
cord-287853-cob7ur35	93	16	like	like	JJ
cord-287853-cob7ur35	93	17	particles	particle	NNS
cord-287853-cob7ur35	93	18	(	(	-LRB-
cord-287853-cob7ur35	93	19	eVLPs	eVLPs	NNP
cord-287853-cob7ur35	93	20	)	)	-RRB-
cord-287853-cob7ur35	93	21	,	,	,
cord-287853-cob7ur35	93	22	an	an	DT
cord-287853-cob7ur35	93	23	isotope	isotope	NN
cord-287853-cob7ur35	93	24	dilution	dilution	NN
cord-287853-cob7ur35	93	25	full	full	JJ
cord-287853-cob7ur35	93	26	-	-	HYPH
cord-287853-cob7ur35	93	27	scan	scan	JJ
cord-287853-cob7ur35	93	28	liquid	liquid	JJ
cord-287853-cob7ur35	93	29	chromatography	chromatography	NN
cord-287853-cob7ur35	93	30	-	-	HYPH
cord-287853-cob7ur35	93	31	high	high	JJ
cord-287853-cob7ur35	93	32	-	-	HYPH
cord-287853-cob7ur35	93	33	resolution	resolution	NN
cord-287853-cob7ur35	93	34	mass	mass	NN
cord-287853-cob7ur35	93	35	spectrometry	spectrometry	NN
cord-287853-cob7ur35	93	36	method	method	NN
cord-287853-cob7ur35	93	37	was	be	VBD
cord-287853-cob7ur35	93	38	developed	develop	VBN
cord-287853-cob7ur35	93	39	using	use	VBG
cord-287853-cob7ur35	93	40	an	an	DT
cord-287853-cob7ur35	93	41	UltiMate	UltiMate	NNP
cord-287853-cob7ur35	93	42	3000	3000	CD
cord-287853-cob7ur35	93	43	HPLC	HPLC	NNP
cord-287853-cob7ur35	93	44	and	and	CC
cord-287853-cob7ur35	93	45	an	an	DT
cord-287853-cob7ur35	93	46	Orbitrap	Orbitrap	NNP
cord-287853-cob7ur35	93	47	Elite	Elite	NNP
cord-287853-cob7ur35	93	48	Hybrid	Hybrid	NNP
cord-287853-cob7ur35	93	49	Ion	Ion	NNP
cord-287853-cob7ur35	93	50	Trap	Trap	NNP
cord-287853-cob7ur35	93	51	-	-	HYPH
cord-287853-cob7ur35	93	52	Orbitrap	Orbitrap	NNP
cord-287853-cob7ur35	93	53	mass	mass	NN
cord-287853-cob7ur35	93	54	spectrometer	spectrometer	NN
cord-287853-cob7ur35	93	55	.	.	.
cord-287853-cob7ur35	94	1	92	92	CD
cord-287853-cob7ur35	95	1	The	the	DT
cord-287853-cob7ur35	95	2	reported	reported	JJ
cord-287853-cob7ur35	95	3	MS	MS	NNP
cord-287853-cob7ur35	95	4	quantitation	quantitation	NN
cord-287853-cob7ur35	95	5	method	method	NN
cord-287853-cob7ur35	95	6	provided	provide	VBN
cord-287853-cob7ur35	95	7	not	not	RB
cord-287853-cob7ur35	95	8	only	only	RB
cord-287853-cob7ur35	95	9	a	a	DT
cord-287853-cob7ur35	95	10	means	means	NN
cord-287853-cob7ur35	95	11	to	to	TO
cord-287853-cob7ur35	95	12	rapidly	rapidly	RB
cord-287853-cob7ur35	95	13	determine	determine	VB
cord-287853-cob7ur35	95	14	eVLP	evlp	JJ
cord-287853-cob7ur35	95	15	batch	batch	NN
cord-287853-cob7ur35	95	16	quality	quality	NN
cord-287853-cob7ur35	95	17	based	base	VBN
cord-287853-cob7ur35	95	18	upon	upon	IN
cord-287853-cob7ur35	95	19	quantitation	quantitation	NN
cord-287853-cob7ur35	95	20	of	of	IN
cord-287853-cob7ur35	95	21	antigenic	antigenic	JJ
cord-287853-cob7ur35	95	22	GP1	gp1	NN
cord-287853-cob7ur35	95	23	but	but	CC
cord-287853-cob7ur35	95	24	also	also	RB
cord-287853-cob7ur35	95	25	ensured	ensure	VBD
cord-287853-cob7ur35	95	26	adequate	adequate	JJ
cord-287853-cob7ur35	95	27	preclinical	preclinical	JJ
cord-287853-cob7ur35	95	28	/	/	SYM
cord-287853-cob7ur35	95	29	clinical	clinical	JJ
cord-287853-cob7ur35	95	30	dosing	dosing	NN
cord-287853-cob7ur35	95	31	.	.	.
cord-287853-cob7ur35	96	1	Chikungunya	chikungunya	NN
cord-287853-cob7ur35	96	2	is	be	VBZ
cord-287853-cob7ur35	96	3	a	a	DT
cord-287853-cob7ur35	96	4	mosquito	mosquito	NN
cord-287853-cob7ur35	96	5	-	-	HYPH
cord-287853-cob7ur35	96	6	borne	bear	VBN
cord-287853-cob7ur35	96	7	viral	viral	JJ
cord-287853-cob7ur35	96	8	disease	disease	NN
cord-287853-cob7ur35	96	9	,	,	,
cord-287853-cob7ur35	96	10	endemic	endemic	JJ
cord-287853-cob7ur35	96	11	in	in	IN
cord-287853-cob7ur35	96	12	Africa	Africa	NNP
cord-287853-cob7ur35	96	13	and	and	CC
cord-287853-cob7ur35	96	14	Southeast	Southeast	NNP
cord-287853-cob7ur35	96	15	Asia	Asia	NNP
cord-287853-cob7ur35	96	16	and	and	CC
cord-287853-cob7ur35	96	17	has	have	VBZ
cord-287853-cob7ur35	96	18	also	also	RB
cord-287853-cob7ur35	96	19	recently	recently	RB
cord-287853-cob7ur35	96	20	emerged	emerge	VBN
cord-287853-cob7ur35	96	21	in	in	IN
cord-287853-cob7ur35	96	22	the	the	DT
cord-287853-cob7ur35	96	23	Caribbean	Caribbean	NNP
cord-287853-cob7ur35	96	24	.	.	.
cord-287853-cob7ur35	97	1	Currently	currently	RB
cord-287853-cob7ur35	97	2	there	there	EX
cord-287853-cob7ur35	97	3	are	be	VBP
cord-287853-cob7ur35	97	4	no	no	DT
cord-287853-cob7ur35	97	5	drugs	drug	NNS
cord-287853-cob7ur35	97	6	or	or	CC
cord-287853-cob7ur35	97	7	vaccines	vaccine	NNS
cord-287853-cob7ur35	97	8	available	available	JJ
cord-287853-cob7ur35	97	9	for	for	IN
cord-287853-cob7ur35	97	10	treatment	treatment	NN
cord-287853-cob7ur35	97	11	or	or	CC
cord-287853-cob7ur35	97	12	prevention	prevention	NN
cord-287853-cob7ur35	97	13	.	.	.
cord-287853-cob7ur35	98	1	The	the	DT
cord-287853-cob7ur35	98	2	name	name	NN
cord-287853-cob7ur35	98	3	"	"	``
cord-287853-cob7ur35	98	4	Chikungunya	chikungunya	NN
cord-287853-cob7ur35	98	5	"	"	''
cord-287853-cob7ur35	98	6	derives	derive	VBZ
cord-287853-cob7ur35	98	7	from	from	IN
cord-287853-cob7ur35	98	8	a	a	DT
cord-287853-cob7ur35	98	9	Makonde	makonde	JJ
cord-287853-cob7ur35	98	10	word	word	NN
cord-287853-cob7ur35	98	11	meaning	meaning	NN
cord-287853-cob7ur35	98	12	"	"	``
cord-287853-cob7ur35	98	13	to	to	TO
cord-287853-cob7ur35	98	14	become	become	VB
cord-287853-cob7ur35	98	15	contorted	contorted	JJ
cord-287853-cob7ur35	98	16	,	,	,
cord-287853-cob7ur35	98	17	"	"	''
cord-287853-cob7ur35	98	18	and	and	CC
cord-287853-cob7ur35	98	19	describes	describe	VBZ
cord-287853-cob7ur35	98	20	the	the	DT
cord-287853-cob7ur35	98	21	stooped	stoop	VBN
cord-287853-cob7ur35	98	22	appearance	appearance	NN
cord-287853-cob7ur35	98	23	of	of	IN
cord-287853-cob7ur35	98	24	sufferers	sufferer	NNS
cord-287853-cob7ur35	98	25	with	with	IN
cord-287853-cob7ur35	98	26	joint	joint	JJ
cord-287853-cob7ur35	98	27	pain	pain	NN
cord-287853-cob7ur35	99	1	(	(	-LRB-
cord-287853-cob7ur35	99	2	arthralgia	arthralgia	NNP
cord-287853-cob7ur35	99	3	MS	MS	NNP
cord-287853-cob7ur35	99	4	-	-	HYPH
cord-287853-cob7ur35	99	5	based	base	VBN
cord-287853-cob7ur35	99	6	approaches	approach	NNS
cord-287853-cob7ur35	99	7	have	have	VBP
cord-287853-cob7ur35	99	8	been	be	VBN
cord-287853-cob7ur35	99	9	used	use	VBN
cord-287853-cob7ur35	99	10	to	to	TO
cord-287853-cob7ur35	99	11	perform	perform	VB
cord-287853-cob7ur35	99	12	the	the	DT
cord-287853-cob7ur35	99	13	physicochemical	physicochemical	JJ
cord-287853-cob7ur35	99	14	characterization	characterization	NN
cord-287853-cob7ur35	99	15	for	for	IN
cord-287853-cob7ur35	99	16	all	all	DT
cord-287853-cob7ur35	99	17	of	of	IN
cord-287853-cob7ur35	99	18	these	these	DT
cord-287853-cob7ur35	99	19	vaccines	vaccine	NNS
cord-287853-cob7ur35	99	20	.	.	.
cord-287853-cob7ur35	100	1	96	96	CD
cord-287853-cob7ur35	101	1	In	in	IN
cord-287853-cob7ur35	101	2	one	one	CD
cord-287853-cob7ur35	101	3	of	of	IN
cord-287853-cob7ur35	101	4	the	the	DT
cord-287853-cob7ur35	101	5	studies	study	NNS
cord-287853-cob7ur35	101	6	,	,	,
cord-287853-cob7ur35	101	7	researchers	researcher	NNS
cord-287853-cob7ur35	101	8	used	use	VBD
cord-287853-cob7ur35	101	9	LC	LC	NNP
cord-287853-cob7ur35	101	10	-	-	HYPH
cord-287853-cob7ur35	101	11	MS	MS	NNP
cord-287853-cob7ur35	101	12	to	to	TO
cord-287853-cob7ur35	101	13	characterize	characterize	VB
cord-287853-cob7ur35	101	14	glycosylated	glycosylated	JJ
cord-287853-cob7ur35	101	15	lysine	lysine	NN
cord-287853-cob7ur35	101	16	residues	residue	NNS
cord-287853-cob7ur35	101	17	in	in	IN
cord-287853-cob7ur35	102	1	Menveo	Menveo	NNP
cord-287853-cob7ur35	102	2	®	®	POS
cord-287853-cob7ur35	102	3	.	.	.
cord-287853-cob7ur35	102	4	97	97	CD
cord-287853-cob7ur35	103	1	In	in	IN
cord-287853-cob7ur35	103	2	another	another	DT
cord-287853-cob7ur35	103	3	study	study	NN
cord-287853-cob7ur35	103	4	a	a	DT
cord-287853-cob7ur35	103	5	LC	LC	NNP
cord-287853-cob7ur35	103	6	-	-	HYPH
cord-287853-cob7ur35	103	7	MS	MS	NNP
cord-287853-cob7ur35	103	8	method	method	NN
cord-287853-cob7ur35	103	9	was	be	VBD
cord-287853-cob7ur35	103	10	used	use	VBN
cord-287853-cob7ur35	103	11	to	to	TO
cord-287853-cob7ur35	103	12	determine	determine	VB
cord-287853-cob7ur35	103	13	the	the	DT
cord-287853-cob7ur35	103	14	relative	relative	JJ
cord-287853-cob7ur35	103	15	reactivity	reactivity	NN
cord-287853-cob7ur35	103	16	of	of	IN
cord-287853-cob7ur35	103	17	lysine	lysine	NN
cord-287853-cob7ur35	103	18	residues	residue	NNS
cord-287853-cob7ur35	103	19	in	in	IN
cord-287853-cob7ur35	103	20	CRM	CRM	NNP
cord-287853-cob7ur35	103	21	197	197	CD
cord-287853-cob7ur35	103	22	to	to	TO
cord-287853-cob7ur35	103	23	determine	determine	VB
cord-287853-cob7ur35	103	24	which	which	WDT
cord-287853-cob7ur35	103	25	of	of	IN
cord-287853-cob7ur35	103	26	these	these	DT
cord-287853-cob7ur35	103	27	amino	amino	NN
cord-287853-cob7ur35	103	28	acids	acid	NNS
cord-287853-cob7ur35	103	29	were	be	VBD
cord-287853-cob7ur35	103	30	more	more	RBR
cord-287853-cob7ur35	103	31	susceptible	susceptible	JJ
cord-287853-cob7ur35	103	32	to	to	IN
cord-287853-cob7ur35	103	33	conjugation	conjugation	NN
cord-287853-cob7ur35	103	34	.	.	.
cord-287853-cob7ur35	104	1	98	98	CD
cord-287853-cob7ur35	104	2	LC	LC	NNP
cord-287853-cob7ur35	104	3	-	-	HYPH
cord-287853-cob7ur35	104	4	MS	MS	NNP
cord-287853-cob7ur35	104	5	was	be	VBD
cord-287853-cob7ur35	104	6	also	also	RB
cord-287853-cob7ur35	104	7	used	use	VBN
cord-287853-cob7ur35	104	8	to	to	TO
cord-287853-cob7ur35	104	9	quantify	quantify	VB
cord-287853-cob7ur35	104	10	the	the	DT
cord-287853-cob7ur35	104	11	Bexsero	Bexsero	NNP
cord-287853-cob7ur35	104	12	®	®	POS
cord-287853-cob7ur35	104	13	vaccine	vaccine	NN
cord-287853-cob7ur35	104	14	which	which	WDT
cord-287853-cob7ur35	104	15	was	be	VBD
cord-287853-cob7ur35	104	16	the	the	DT
cord-287853-cob7ur35	104	17	first	first	JJ
cord-287853-cob7ur35	104	18	vaccine	vaccine	NN
cord-287853-cob7ur35	104	19	developed	develop	VBN
cord-287853-cob7ur35	104	20	by	by	IN
cord-287853-cob7ur35	104	21	reverse	reverse	JJ
cord-287853-cob7ur35	104	22	vaccinology	vaccinology	NN
cord-287853-cob7ur35	104	23	;	;	:
cord-287853-cob7ur35	104	24	a	a	DT
cord-287853-cob7ur35	104	25	genome	genome	NN
cord-287853-cob7ur35	104	26	-	-	HYPH
cord-287853-cob7ur35	104	27	based	base	VBN
cord-287853-cob7ur35	104	28	approach	approach	NN
cord-287853-cob7ur35	104	29	to	to	IN
cord-287853-cob7ur35	104	30	vaccine	vaccine	NN
cord-287853-cob7ur35	104	31	development	development	NN
cord-287853-cob7ur35	104	32	.	.	.
cord-287853-cob7ur35	105	1	99	99	CD
cord-287853-cob7ur35	105	2	in	in	IN
cord-287853-cob7ur35	105	3	the	the	DT
cord-287853-cob7ur35	105	4	field	field	NN
cord-287853-cob7ur35	105	5	of	of	IN
cord-287853-cob7ur35	105	6	vaccines	vaccine	NNS
cord-287853-cob7ur35	105	7	,	,	,
cord-287853-cob7ur35	105	8	Vera	Vera	NNP
cord-287853-cob7ur35	105	9	-	-	HYPH
cord-287853-cob7ur35	105	10	Velasco	Velasco	NNP
cord-287853-cob7ur35	105	11	et	et	NNP
cord-287853-cob7ur35	105	12	al	al	NNP
cord-287853-cob7ur35	105	13	not	not	RB
cord-287853-cob7ur35	105	14	only	only	RB
cord-287853-cob7ur35	105	15	quantified	quantify	VBD
cord-287853-cob7ur35	105	16	the	the	DT
cord-287853-cob7ur35	105	17	viral	viral	JJ
cord-287853-cob7ur35	105	18	F	f	NN
cord-287853-cob7ur35	105	19	,	,	,
cord-287853-cob7ur35	105	20	G	G	NNP
cord-287853-cob7ur35	105	21	and	and	CC
cord-287853-cob7ur35	105	22	M	M	NNP
cord-287853-cob7ur35	105	23	proteins	protein	NNS
cord-287853-cob7ur35	105	24	present	present	JJ
cord-287853-cob7ur35	105	25	in	in	IN
cord-287853-cob7ur35	105	26	the	the	DT
cord-287853-cob7ur35	105	27	viral	viral	JJ
cord-287853-cob7ur35	105	28	particles	particle	NNS
cord-287853-cob7ur35	105	29	but	but	CC
cord-287853-cob7ur35	105	30	also	also	RB
cord-287853-cob7ur35	105	31	analyzed	analyze	VBD
cord-287853-cob7ur35	105	32	the	the	DT
cord-287853-cob7ur35	105	33	cellular	cellular	JJ
cord-287853-cob7ur35	105	34	proteomic	proteomic	JJ
cord-287853-cob7ur35	105	35	composition	composition	NN
cord-287853-cob7ur35	105	36	in	in	IN
cord-287853-cob7ur35	105	37	the	the	DT
cord-287853-cob7ur35	105	38	NiV	niv	JJ
cord-287853-cob7ur35	105	39	vaccine	vaccine	NN
cord-287853-cob7ur35	105	40	candidate	candidate	NN
cord-287853-cob7ur35	105	41	.	.	.
cord-287853-cob7ur35	106	1	Traditionally	traditionally	RB
cord-287853-cob7ur35	106	2	,	,	,
cord-287853-cob7ur35	106	3	viral	viral	JJ
cord-287853-cob7ur35	106	4	particles	particle	NNS
cord-287853-cob7ur35	106	5	have	have	VBP
cord-287853-cob7ur35	106	6	been	be	VBN
cord-287853-cob7ur35	106	7	described	describe	VBN
cord-287853-cob7ur35	106	8	as	as	IN
cord-287853-cob7ur35	106	9	pure	pure	JJ
cord-287853-cob7ur35	106	10	entities	entity	NNS
cord-287853-cob7ur35	106	11	carrying	carry	VBG
cord-287853-cob7ur35	106	12	only	only	RB
cord-287853-cob7ur35	106	13	viral	viral	RB
cord-287853-cob7ur35	106	14	-	-	HYPH
cord-287853-cob7ur35	106	15	derived	derive	VBN
cord-287853-cob7ur35	106	16	proteins	protein	NNS
cord-287853-cob7ur35	106	17	but	but	CC
cord-287853-cob7ur35	106	18	the	the	DT
cord-287853-cob7ur35	106	19	authors	author	NNS
cord-287853-cob7ur35	106	20	successfully	successfully	RB
cord-287853-cob7ur35	106	21	analyzed	analyze	VBD
cord-287853-cob7ur35	106	22	the	the	DT
cord-287853-cob7ur35	106	23	ratio	ratio	NN
cord-287853-cob7ur35	106	24	between	between	IN
cord-287853-cob7ur35	106	25	cellular	cellular	JJ
cord-287853-cob7ur35	106	26	and	and	CC
cord-287853-cob7ur35	106	27	viral	viral	JJ
cord-287853-cob7ur35	106	28	proteins	protein	NNS
cord-287853-cob7ur35	106	29	in	in	IN
cord-287853-cob7ur35	106	30	the	the	DT
cord-287853-cob7ur35	106	31	NiV	niv	JJ
cord-287853-cob7ur35	106	32	vaccine	vaccine	NN
cord-287853-cob7ur35	106	33	candidate	candidate	NN
cord-287853-cob7ur35	106	34	using	use	VBG
cord-287853-cob7ur35	106	35	LC	LC	NNP
cord-287853-cob7ur35	106	36	-	-	HYPH
cord-287853-cob7ur35	106	37	MS	MS	NNP
cord-287853-cob7ur35	106	38	/	/	SYM
cord-287853-cob7ur35	106	39	MS	MS	NNP
cord-287853-cob7ur35	106	40	.	.	.
cord-287853-cob7ur35	107	1	108	108	CD
cord-287853-cob7ur35	107	2	West	West	NNP
cord-287853-cob7ur35	107	3	Nile	Nile	NNP
cord-287853-cob7ur35	107	4	fever	fever	NN
cord-287853-cob7ur35	107	5	is	be	VBZ
cord-287853-cob7ur35	107	6	a	a	DT
cord-287853-cob7ur35	107	7	flavivirus	flavivirus	NN
cord-287853-cob7ur35	107	8	that	that	WDT
cord-287853-cob7ur35	107	9	causes	cause	VBZ
cord-287853-cob7ur35	107	10	a	a	DT
cord-287853-cob7ur35	107	11	viral	viral	JJ
cord-287853-cob7ur35	107	12	infection	infection	NN
cord-287853-cob7ur35	107	13	typically	typically	RB
cord-287853-cob7ur35	107	14	spread	spread	VBN
cord-287853-cob7ur35	107	15	by	by	IN
cord-287853-cob7ur35	107	16	mosquitoes	mosquito	NNS
cord-287853-cob7ur35	107	17	.	.	.
cord-287853-cob7ur35	108	1	To	to	IN
cord-287853-cob7ur35	108	2	date	date	NN
cord-287853-cob7ur35	108	3	,	,	,
cord-287853-cob7ur35	108	4	no	no	DT
cord-287853-cob7ur35	108	5	vaccine	vaccine	NN
cord-287853-cob7ur35	108	6	is	be	VBZ
cord-287853-cob7ur35	108	7	available	available	JJ
cord-287853-cob7ur35	108	8	to	to	TO
cord-287853-cob7ur35	108	9	prevent	prevent	VB
cord-287853-cob7ur35	108	10	the	the	DT
cord-287853-cob7ur35	108	11	West	West	NNP
cord-287853-cob7ur35	108	12	Nile	Nile	NNP
cord-287853-cob7ur35	108	13	infection	infection	NN
cord-287853-cob7ur35	108	14	.	.	.
cord-287853-cob7ur35	109	1	Partially	partially	RB
cord-287853-cob7ur35	109	2	purified	purify	VBN
cord-287853-cob7ur35	109	3	virus	virus	NN
cord-287853-cob7ur35	109	4	-	-	HYPH
cord-287853-cob7ur35	109	5	like	like	JJ
cord-287853-cob7ur35	109	6	particles	particle	NNS
cord-287853-cob7ur35	109	7	were	be	VBD
cord-287853-cob7ur35	109	8	resolved	resolve	VBN
cord-287853-cob7ur35	109	9	by	by	IN
cord-287853-cob7ur35	109	10	SDS	SDS	NNP
cord-287853-cob7ur35	109	11	-	-	HYPH
cord-287853-cob7ur35	109	12	PAGE	PAGE	NNP
cord-287853-cob7ur35	109	13	,	,	,
cord-287853-cob7ur35	109	14	and	and	CC
cord-287853-cob7ur35	109	15	the	the	DT
cord-287853-cob7ur35	109	16	Coomassie	Coomassie	NNP
cord-287853-cob7ur35	109	17	blue	blue	JJ
cord-287853-cob7ur35	109	18	-	-	HYPH
cord-287853-cob7ur35	109	19	stained	stained	JJ
cord-287853-cob7ur35	109	20	band	band	NN
cord-287853-cob7ur35	109	21	corresponding	correspond	VBG
cord-287853-cob7ur35	109	22	to	to	IN
cord-287853-cob7ur35	109	23	Env	Env	NNP
cord-287853-cob7ur35	109	24	protein	protein	NN
cord-287853-cob7ur35	109	25	was	be	VBD
cord-287853-cob7ur35	109	26	excised	excise	VBN
cord-287853-cob7ur35	109	27	from	from	IN
cord-287853-cob7ur35	109	28	the	the	DT
cord-287853-cob7ur35	109	29	gel	gel	NN
cord-287853-cob7ur35	109	30	,	,	,
cord-287853-cob7ur35	109	31	destained	destain	VBN
cord-287853-cob7ur35	109	32	,	,	,
cord-287853-cob7ur35	109	33	and	and	CC
cord-287853-cob7ur35	109	34	analyzed	analyze	VBN
cord-287853-cob7ur35	109	35	by	by	IN
cord-287853-cob7ur35	109	36	MS	MS	NNP
cord-287853-cob7ur35	109	37	.	.	.
cord-287853-cob7ur35	110	1	Microcapillary	Microcapillary	NNP
cord-287853-cob7ur35	110	2	LC	LC	NNP
cord-287853-cob7ur35	110	3	-	-	HYPH
cord-287853-cob7ur35	110	4	MS	MS	NNP
cord-287853-cob7ur35	110	5	was	be	VBD
cord-287853-cob7ur35	110	6	performed	perform	VBN
cord-287853-cob7ur35	110	7	using	use	VBG
cord-287853-cob7ur35	110	8	a	a	DT
cord-287853-cob7ur35	110	9	LCQ	LCQ	NNP
cord-287853-cob7ur35	110	10	DECA	DECA	NNP
cord-287853-cob7ur35	110	11	ion	ion	NN
cord-287853-cob7ur35	110	12	-	-	HYPH
cord-287853-cob7ur35	110	13	trap	trap	NN
cord-287853-cob7ur35	110	14	mass	mass	NN
cord-287853-cob7ur35	110	15	spectrometer	spectrometer	NN
cord-287853-cob7ur35	110	16	(	(	-LRB-
cord-287853-cob7ur35	110	17	Thermo	Thermo	NNP
cord-287853-cob7ur35	110	18	Finnigan	Finnigan	NNP
cord-287853-cob7ur35	110	19	)	)	-RRB-
cord-287853-cob7ur35	110	20	to	to	TO
cord-287853-cob7ur35	110	21	identify	identify	VB
cord-287853-cob7ur35	110	22	the	the	DT
cord-287853-cob7ur35	110	23	presence	presence	NN
cord-287853-cob7ur35	110	24	of	of	IN
cord-287853-cob7ur35	110	25	Env	Env	NNP
cord-287853-cob7ur35	110	26	protein	protein	NN
cord-287853-cob7ur35	110	27	in	in	IN
cord-287853-cob7ur35	110	28	virus	virus	NN
cord-287853-cob7ur35	110	29	-	-	HYPH
cord-287853-cob7ur35	110	30	like	like	JJ
cord-287853-cob7ur35	110	31	particles	particle	NNS
cord-287853-cob7ur35	110	32	to	to	TO
cord-287853-cob7ur35	110	33	help	help	VB
cord-287853-cob7ur35	110	34	in	in	IN
cord-287853-cob7ur35	110	35	developing	develop	VBG
cord-287853-cob7ur35	110	36	a	a	DT
cord-287853-cob7ur35	110	37	potential	potential	JJ
cord-287853-cob7ur35	110	38	vaccine	vaccine	NN
cord-287853-cob7ur35	110	39	.	.	.
cord-287853-cob7ur35	111	1	109	109	CD
cord-287853-cob7ur35	112	1	In	in	IN
cord-287853-cob7ur35	112	2	should	should	MD
cord-287853-cob7ur35	112	3	be	be	VB
cord-287853-cob7ur35	112	4	a	a	DT
cord-287853-cob7ur35	112	5	supplemental	supplemental	JJ
cord-287853-cob7ur35	112	6	batch	batch	NN
cord-287853-cob7ur35	112	7	release	release	NN
cord-287853-cob7ur35	112	8	test	test	NN
cord-287853-cob7ur35	112	9	to	to	TO
cord-287853-cob7ur35	112	10	ensure	ensure	VB
cord-287853-cob7ur35	112	11	that	that	IN
cord-287853-cob7ur35	112	12	the	the	DT
cord-287853-cob7ur35	112	13	product	product	NN
cord-287853-cob7ur35	112	14	is	be	VBZ
cord-287853-cob7ur35	112	15	within	within	IN
cord-287853-cob7ur35	112	16	specifications	specification	NNS
cord-287853-cob7ur35	112	17	and	and	CC
cord-287853-cob7ur35	112	18	without	without	IN
cord-287853-cob7ur35	112	19	any	any	DT
cord-287853-cob7ur35	112	20	unwarranted	unwarranted	JJ
cord-287853-cob7ur35	112	21	modifications	modification	NNS
cord-287853-cob7ur35	112	22	.	.	.
cord-287853-cob7ur35	113	1	Using	use	VBG
cord-287853-cob7ur35	113	2	MS	MS	NNP
cord-287853-cob7ur35	113	3	techniques	technique	NNS
cord-287853-cob7ur35	113	4	will	will	MD
cord-287853-cob7ur35	113	5	ensure	ensure	VB
cord-287853-cob7ur35	113	6	improved	improved	JJ
cord-287853-cob7ur35	113	7	quality	quality	NN
cord-287853-cob7ur35	113	8	and	and	CC
cord-287853-cob7ur35	113	9	increased	increase	VBN
cord-287853-cob7ur35	113	10	safety	safety	NN
cord-287853-cob7ur35	113	11	for	for	IN
cord-287853-cob7ur35	113	12	clinical	clinical	JJ
cord-287853-cob7ur35	113	13	trial	trial	NN
cord-287853-cob7ur35	113	14	participants	participant	NNS
cord-287853-cob7ur35	113	15	.	.	.
cord-287853-cob7ur35	114	1	In	in	IN
cord-287853-cob7ur35	114	2	conclusion	conclusion	NN
cord-287853-cob7ur35	114	3	,	,	,
cord-287853-cob7ur35	114	4	the	the	DT
cord-287853-cob7ur35	114	5	evidence	evidence	NN
cord-287853-cob7ur35	114	6	suggests	suggest	VBZ
cord-287853-cob7ur35	114	7	that	that	IN
cord-287853-cob7ur35	114	8	the	the	DT
cord-287853-cob7ur35	114	9	emergence	emergence	NN
cord-287853-cob7ur35	114	10	of	of	IN
cord-287853-cob7ur35	114	11	MS	MS	NNP
cord-287853-cob7ur35	114	12	-	-	HYPH
cord-287853-cob7ur35	114	13	based	base	VBN
cord-287853-cob7ur35	114	14	techniques	technique	NNS
cord-287853-cob7ur35	114	15	has	have	VBZ
cord-287853-cob7ur35	114	16	advanced	advance	VBN
cord-287853-cob7ur35	114	17	the	the	DT
cord-287853-cob7ur35	114	18	field	field	NN
cord-287853-cob7ur35	114	19	of	of	IN
cord-287853-cob7ur35	114	20	vaccine	vaccine	NN
cord-287853-cob7ur35	114	21	development	development	NN
cord-287853-cob7ur35	114	22	.	.	.
cord-287853-cob7ur35	114	23	 	 	_SP
cord-287853-cob7ur35	115	1	History	history	NN
cord-287853-cob7ur35	115	2	of	of	IN
cord-287853-cob7ur35	115	3	vaccination	vaccination	NN
cord-287853-cob7ur35	115	4	Vaccines	vaccine	NNS
cord-287853-cob7ur35	115	5	,	,	,
cord-287853-cob7ur35	115	6	new	new	JJ
cord-287853-cob7ur35	115	7	opportunities	opportunity	NNS
cord-287853-cob7ur35	115	8	for	for	IN
cord-287853-cob7ur35	115	9	a	a	DT
cord-287853-cob7ur35	115	10	new	new	JJ
cord-287853-cob7ur35	115	11	society	society	NN
cord-287853-cob7ur35	115	12	Research	research	NN
cord-287853-cob7ur35	115	13	and	and	CC
cord-287853-cob7ur35	115	14	development	development	NN
cord-287853-cob7ur35	115	15	of	of	IN
cord-287853-cob7ur35	115	16	new	new	JJ
cord-287853-cob7ur35	115	17	vaccines	vaccine	NNS
cord-287853-cob7ur35	115	18	against	against	IN
cord-287853-cob7ur35	115	19	infectious	infectious	JJ
cord-287853-cob7ur35	115	20	diseases	disease	NNS
cord-287853-cob7ur35	115	21	Recombinant	recombinant	JJ
cord-287853-cob7ur35	115	22	and	and	CC
cord-287853-cob7ur35	115	23	epitope	epitope	NN
cord-287853-cob7ur35	115	24	-	-	HYPH
cord-287853-cob7ur35	115	25	based	base	VBN
cord-287853-cob7ur35	115	26	vaccines	vaccine	NNS
cord-287853-cob7ur35	115	27	on	on	IN
cord-287853-cob7ur35	115	28	the	the	DT
cord-287853-cob7ur35	115	29	road	road	NN
cord-287853-cob7ur35	115	30	to	to	IN
cord-287853-cob7ur35	115	31	the	the	DT
cord-287853-cob7ur35	115	32	market	market	NN
cord-287853-cob7ur35	115	33	and	and	CC
cord-287853-cob7ur35	115	34	implications	implication	NNS
cord-287853-cob7ur35	115	35	for	for	IN
cord-287853-cob7ur35	115	36	vaccine	vaccine	NN
cord-287853-cob7ur35	115	37	design	design	NN
cord-287853-cob7ur35	115	38	and	and	CC
cord-287853-cob7ur35	115	39	production	production	NN
cord-287853-cob7ur35	115	40	.	.	.
cord-287853-cob7ur35	116	1	Hum	Hum	NNP
cord-287853-cob7ur35	116	2	Vaccines	vaccine	NNS
cord-287853-cob7ur35	116	3	Immunother	Immunother	NNP
cord-287853-cob7ur35	117	1	The	the	DT
cord-287853-cob7ur35	117	2	challenge	challenge	NN
cord-287853-cob7ur35	117	3	of	of	IN
cord-287853-cob7ur35	117	4	emerging	emerge	VBG
cord-287853-cob7ur35	117	5	and	and	CC
cord-287853-cob7ur35	117	6	reemerging	reemerge	VBG
cord-287853-cob7ur35	117	7	infectious	infectious	JJ
cord-287853-cob7ur35	117	8	diseases	disease	NNS
cord-287853-cob7ur35	117	9	Emerging	emerge	VBG
cord-287853-cob7ur35	117	10	infectious	infectious	JJ
cord-287853-cob7ur35	117	11	diseases	disease	NNS
cord-287853-cob7ur35	117	12	:	:	:
cord-287853-cob7ur35	117	13	threats	threat	NNS
cord-287853-cob7ur35	117	14	to	to	IN
cord-287853-cob7ur35	117	15	human	human	JJ
cord-287853-cob7ur35	117	16	health	health	NN
cord-287853-cob7ur35	117	17	and	and	CC
cord-287853-cob7ur35	117	18	global	global	JJ
cord-287853-cob7ur35	117	19	stability	stability	NN
cord-287853-cob7ur35	117	20	Establishing	establish	VBG
cord-287853-cob7ur35	117	21	a	a	DT
cord-287853-cob7ur35	117	22	global	global	JJ
cord-287853-cob7ur35	117	23	vaccinedevelopment	vaccinedevelopment	NN
cord-287853-cob7ur35	117	24	fund	fund	NN
cord-287853-cob7ur35	118	1	New	new	JJ
cord-287853-cob7ur35	118	2	vaccines	vaccine	NNS
cord-287853-cob7ur35	118	3	against	against	IN
cord-287853-cob7ur35	118	4	epidemic	epidemic	NN
cord-287853-cob7ur35	118	5	infectious	infectious	JJ
cord-287853-cob7ur35	118	6	diseases	disease	NNS
cord-287853-cob7ur35	118	7	Recombinant	recombinant	JJ
cord-287853-cob7ur35	118	8	subunit	subunit	NN
cord-287853-cob7ur35	118	9	vaccines	vaccine	NNS
cord-287853-cob7ur35	118	10	:	:	:
cord-287853-cob7ur35	118	11	potentials	potential	NNS
cord-287853-cob7ur35	118	12	and	and	CC
cord-287853-cob7ur35	118	13	constraints	constraint	NNS
cord-287853-cob7ur35	119	1	Recombinant	recombinant	JJ
cord-287853-cob7ur35	119	2	therapeutic	therapeutic	JJ
cord-287853-cob7ur35	119	3	protein	protein	NN
cord-287853-cob7ur35	119	4	vaccines	vaccine	NNS
cord-287853-cob7ur35	119	5	Virus	virus	NN
cord-287853-cob7ur35	119	6	-	-	HYPH
cord-287853-cob7ur35	119	7	like	like	JJ
cord-287853-cob7ur35	119	8	particles	particle	NNS
cord-287853-cob7ur35	119	9	as	as	IN
cord-287853-cob7ur35	119	10	vaccine	vaccine	NN
cord-287853-cob7ur35	119	11	Viral	viral	JJ
cord-287853-cob7ur35	119	12	vaccines	vaccine	NNS
cord-287853-cob7ur35	119	13	and	and	CC
cord-287853-cob7ur35	119	14	their	-PRON-	PRP$
cord-287853-cob7ur35	119	15	manufacturing	manufacturing	NN
cord-287853-cob7ur35	119	16	cell	cell	NN
cord-287853-cob7ur35	119	17	substrates	substrate	NNS
cord-287853-cob7ur35	119	18	:	:	:
cord-287853-cob7ur35	119	19	New	new	JJ
cord-287853-cob7ur35	119	20	trends	trend	NNS
cord-287853-cob7ur35	119	21	and	and	CC
cord-287853-cob7ur35	119	22	designs	design	NNS
cord-287853-cob7ur35	119	23	in	in	IN
cord-287853-cob7ur35	119	24	modern	modern	JJ
cord-287853-cob7ur35	119	25	vaccinology	vaccinology	NN
cord-287853-cob7ur35	119	26	Cell	cell	NN
cord-287853-cob7ur35	119	27	culture	culture	NN
cord-287853-cob7ur35	119	28	technology	technology	NN
cord-287853-cob7ur35	119	29	Protein	Protein	NNP
cord-287853-cob7ur35	119	30	subunit	subunit	NN
cord-287853-cob7ur35	119	31	vaccine	vaccine	NN
cord-287853-cob7ur35	119	32	purification	purification	NN
cord-287853-cob7ur35	119	33	CGMP	CGMP	NNP
cord-287853-cob7ur35	119	34	production	production	NN
cord-287853-cob7ur35	119	35	and	and	CC
cord-287853-cob7ur35	119	36	analysis	analysis	NN
cord-287853-cob7ur35	119	37	of	of	IN
cord-287853-cob7ur35	119	38	BG505	BG505	NNP
cord-287853-cob7ur35	119	39	SOSIP	SOSIP	NNP
cord-287853-cob7ur35	119	40	.	.	.
cord-287853-cob7ur35	120	1	664	664	CD
cord-287853-cob7ur35	120	2	,	,	,
cord-287853-cob7ur35	120	3	an	an	DT
cord-287853-cob7ur35	120	4	extensively	extensively	RB
cord-287853-cob7ur35	120	5	glycosylated	glycosylate	VBN
cord-287853-cob7ur35	120	6	,	,	,
cord-287853-cob7ur35	120	7	trimeric	trimeric	NNP
cord-287853-cob7ur35	120	8	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	120	9	envelope	envelope	NN
cord-287853-cob7ur35	120	10	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	120	11	vaccine	vaccine	NN
cord-287853-cob7ur35	120	12	candidate	candidate	NN
cord-287853-cob7ur35	120	13	A	a	DT
cord-287853-cob7ur35	120	14	systematic	systematic	JJ
cord-287853-cob7ur35	120	15	approach	approach	NN
cord-287853-cob7ur35	120	16	to	to	IN
cord-287853-cob7ur35	120	17	protein	protein	NN
cord-287853-cob7ur35	120	18	glycosylation	glycosylation	NN
cord-287853-cob7ur35	120	19	analysis	analysis	NN
cord-287853-cob7ur35	120	20	:	:	:
cord-287853-cob7ur35	120	21	a	a	DT
cord-287853-cob7ur35	120	22	path	path	NN
cord-287853-cob7ur35	120	23	through	through	IN
cord-287853-cob7ur35	120	24	the	the	DT
cord-287853-cob7ur35	120	25	maze	maze	NN
cord-287853-cob7ur35	120	26	Structural	structural	JJ
cord-287853-cob7ur35	120	27	mass	mass	NN
cord-287853-cob7ur35	120	28	spectrometry	spectrometry	NN
cord-287853-cob7ur35	120	29	in	in	IN
cord-287853-cob7ur35	120	30	biologics	biologic	NNS
cord-287853-cob7ur35	120	31	discovery	discovery	NN
cord-287853-cob7ur35	120	32	:	:	:
cord-287853-cob7ur35	120	33	advances	advance	NNS
cord-287853-cob7ur35	120	34	and	and	CC
cord-287853-cob7ur35	120	35	future	future	JJ
cord-287853-cob7ur35	120	36	trends	trend	NNS
cord-287853-cob7ur35	120	37	Impact	Impact	NNP
cord-287853-cob7ur35	120	38	of	of	IN
cord-287853-cob7ur35	120	39	host	host	NN
cord-287853-cob7ur35	120	40	cell	cell	NN
cord-287853-cob7ur35	120	41	line	line	NN
cord-287853-cob7ur35	120	42	choice	choice	NN
cord-287853-cob7ur35	120	43	on	on	IN
cord-287853-cob7ur35	120	44	glycan	glycan	NN
cord-287853-cob7ur35	120	45	profile	profile	NN
cord-287853-cob7ur35	120	46	Therapeutic	therapeutic	JJ
cord-287853-cob7ur35	120	47	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	120	48	production	production	NN
cord-287853-cob7ur35	120	49	in	in	IN
cord-287853-cob7ur35	120	50	mammalian	mammalian	JJ
cord-287853-cob7ur35	120	51	cells	cell	NNS
cord-287853-cob7ur35	120	52	Analysis	Analysis	NNP
cord-287853-cob7ur35	120	53	of	of	IN
cord-287853-cob7ur35	120	54	protein	protein	NN
cord-287853-cob7ur35	120	55	glycosylation	glycosylation	NN
cord-287853-cob7ur35	120	56	by	by	IN
cord-287853-cob7ur35	120	57	mass	mass	NN
cord-287853-cob7ur35	120	58	spectrometry	spectrometry	NN
cord-287853-cob7ur35	120	59	Carbohydrates	carbohydrate	NNS
cord-287853-cob7ur35	120	60	on	on	IN
cord-287853-cob7ur35	120	61	proteins	protein	NNS
cord-287853-cob7ur35	120	62	:	:	:
cord-287853-cob7ur35	120	63	site	site	NN
cord-287853-cob7ur35	120	64	-	-	HYPH
cord-287853-cob7ur35	120	65	specific	specific	JJ
cord-287853-cob7ur35	120	66	glycosylation	glycosylation	NN
cord-287853-cob7ur35	120	67	analysis	analysis	NN
cord-287853-cob7ur35	120	68	by	by	IN
cord-287853-cob7ur35	120	69	mass	mass	NN
cord-287853-cob7ur35	120	70	spectrometry	spectrometry	NNP
cord-287853-cob7ur35	120	71	Recent	recent	JJ
cord-287853-cob7ur35	120	72	mass	mass	NN
cord-287853-cob7ur35	120	73	spectrometry	spectrometry	NN
cord-287853-cob7ur35	120	74	-	-	HYPH
cord-287853-cob7ur35	120	75	based	base	VBN
cord-287853-cob7ur35	120	76	techniques	technique	NNS
cord-287853-cob7ur35	120	77	and	and	CC
cord-287853-cob7ur35	120	78	considerations	consideration	NNS
cord-287853-cob7ur35	120	79	for	for	IN
cord-287853-cob7ur35	120	80	disulfide	disulfide	JJ
cord-287853-cob7ur35	120	81	bond	bond	NN
cord-287853-cob7ur35	120	82	characterization	characterization	NN
cord-287853-cob7ur35	120	83	in	in	IN
cord-287853-cob7ur35	120	84	proteins	protein	NNS
cord-287853-cob7ur35	121	1	Comprehensive	comprehensive	JJ
cord-287853-cob7ur35	121	2	tracking	tracking	NN
cord-287853-cob7ur35	121	3	of	of	IN
cord-287853-cob7ur35	121	4	host	host	NN
cord-287853-cob7ur35	121	5	cell	cell	NN
cord-287853-cob7ur35	121	6	proteins	protein	NNS
cord-287853-cob7ur35	121	7	during	during	IN
cord-287853-cob7ur35	121	8	monoclonal	monoclonal	JJ
cord-287853-cob7ur35	121	9	antibody	antibody	NN
cord-287853-cob7ur35	121	10	purifications	purification	NNS
cord-287853-cob7ur35	121	11	using	use	VBG
cord-287853-cob7ur35	121	12	mass	mass	NN
cord-287853-cob7ur35	121	13	spectrometry	spectrometry	NN
cord-287853-cob7ur35	122	1	The	the	DT
cord-287853-cob7ur35	122	2	quest	quest	NN
cord-287853-cob7ur35	122	3	for	for	IN
cord-287853-cob7ur35	122	4	an	an	DT
cord-287853-cob7ur35	122	5	antibody	antibody	NN
cord-287853-cob7ur35	122	6	-	-	HYPH
cord-287853-cob7ur35	122	7	based	base	VBN
cord-287853-cob7ur35	122	8	HIV	HIV	NNP
cord-287853-cob7ur35	122	9	vaccine	vaccine	NN
cord-287853-cob7ur35	122	10	Developing	develop	VBG
cord-287853-cob7ur35	122	11	an	an	DT
cord-287853-cob7ur35	122	12	HIV	HIV	NNP
cord-287853-cob7ur35	122	13	vaccine	vaccine	NN
cord-287853-cob7ur35	122	14	Vaccination	vaccination	NN
cord-287853-cob7ur35	122	15	with	with	IN
cord-287853-cob7ur35	122	16	ALVAC	ALVAC	NNP
cord-287853-cob7ur35	122	17	and	and	CC
cord-287853-cob7ur35	122	18	AIDSVAX	AIDSVAX	NNP
cord-287853-cob7ur35	122	19	to	to	TO
cord-287853-cob7ur35	122	20	prevent	prevent	VB
cord-287853-cob7ur35	122	21	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	122	22	infection	infection	NN
cord-287853-cob7ur35	122	23	in	in	IN
cord-287853-cob7ur35	122	24	Thailand	Thailand	NNP
cord-287853-cob7ur35	122	25	New	New	NNP
cord-287853-cob7ur35	122	26	approaches	approach	NNS
cord-287853-cob7ur35	122	27	to	to	IN
cord-287853-cob7ur35	122	28	HIV	HIV	NNP
cord-287853-cob7ur35	122	29	vaccine	vaccine	NN
cord-287853-cob7ur35	122	30	development	development	NN
cord-287853-cob7ur35	122	31	Antigenicity	Antigenicity	NNP
cord-287853-cob7ur35	122	32	and	and	CC
cord-287853-cob7ur35	122	33	immunogenicity	immunogenicity	NN
cord-287853-cob7ur35	122	34	of	of	IN
cord-287853-cob7ur35	122	35	RV144	rv144	JJ
cord-287853-cob7ur35	122	36	vaccine	vaccine	NN
cord-287853-cob7ur35	122	37	AIDSVAX	AIDSVAX	NNP
cord-287853-cob7ur35	122	38	clade	clade	NN
cord-287853-cob7ur35	122	39	E	e	NN
cord-287853-cob7ur35	122	40	envelope	envelope	NN
cord-287853-cob7ur35	122	41	immunogen	immunogen	NN
cord-287853-cob7ur35	122	42	is	be	VBZ
cord-287853-cob7ur35	122	43	enhanced	enhance	VBN
cord-287853-cob7ur35	122	44	by	by	IN
cord-287853-cob7ur35	122	45	a	a	DT
cord-287853-cob7ur35	122	46	gp120	gp120	NNP
cord-287853-cob7ur35	122	47	N	n	CD
cord-287853-cob7ur35	122	48	-	-	HYPH
cord-287853-cob7ur35	122	49	terminal	terminal	NN
cord-287853-cob7ur35	122	50	deletion	deletion	NN
cord-287853-cob7ur35	122	51	Comparable	comparable	JJ
cord-287853-cob7ur35	122	52	antigenicity	antigenicity	NN
cord-287853-cob7ur35	122	53	and	and	CC
cord-287853-cob7ur35	122	54	immunogenicity	immunogenicity	NN
cord-287853-cob7ur35	122	55	of	of	IN
cord-287853-cob7ur35	122	56	oligomeric	oligomeric	JJ
cord-287853-cob7ur35	122	57	forms	form	NNS
cord-287853-cob7ur35	122	58	of	of	IN
cord-287853-cob7ur35	122	59	a	a	DT
cord-287853-cob7ur35	122	60	novel	novel	NN
cord-287853-cob7ur35	122	61	,	,	,
cord-287853-cob7ur35	122	62	acute	acute	JJ
cord-287853-cob7ur35	122	63	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	122	64	subtype	subtype	NN
cord-287853-cob7ur35	122	65	C	c	NN
cord-287853-cob7ur35	122	66	gp145	gp145	CC
cord-287853-cob7ur35	122	67	envelope	envelope	NN
cord-287853-cob7ur35	122	68	for	for	IN
cord-287853-cob7ur35	122	69	use	use	NN
cord-287853-cob7ur35	122	70	in	in	IN
cord-287853-cob7ur35	122	71	preclinical	preclinical	JJ
cord-287853-cob7ur35	122	72	and	and	CC
cord-287853-cob7ur35	122	73	clinical	clinical	JJ
cord-287853-cob7ur35	122	74	vaccine	vaccine	NN
cord-287853-cob7ur35	122	75	research	research	NN
cord-287853-cob7ur35	122	76	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	122	77	envelope	envelope	NN
cord-287853-cob7ur35	122	78	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	122	79	immunogens	immunogen	VBZ
cord-287853-cob7ur35	122	80	to	to	TO
cord-287853-cob7ur35	122	81	induce	induce	VB
cord-287853-cob7ur35	122	82	broadly	broadly	RB
cord-287853-cob7ur35	122	83	neutralizing	neutralize	VBG
cord-287853-cob7ur35	122	84	antibodies	antibody	NNS
cord-287853-cob7ur35	122	85	The	the	DT
cord-287853-cob7ur35	122	86	HIV	HIV	NNP
cord-287853-cob7ur35	122	87	glycan	glycan	NN
cord-287853-cob7ur35	122	88	shield	shield	NN
cord-287853-cob7ur35	122	89	as	as	IN
cord-287853-cob7ur35	122	90	a	a	DT
cord-287853-cob7ur35	122	91	target	target	NN
cord-287853-cob7ur35	122	92	for	for	IN
cord-287853-cob7ur35	122	93	broadly	broadly	RB
cord-287853-cob7ur35	122	94	neutralizing	neutralize	VBG
cord-287853-cob7ur35	122	95	antibodies	antibody	NNS
cord-287853-cob7ur35	122	96	Assignment	Assignment	NNP
cord-287853-cob7ur35	122	97	of	of	IN
cord-287853-cob7ur35	122	98	intrachain	intrachain	NNP
cord-287853-cob7ur35	122	99	disulfide	disulfide	NN
cord-287853-cob7ur35	122	100	bonds	bond	NNS
cord-287853-cob7ur35	122	101	and	and	CC
cord-287853-cob7ur35	122	102	characterization	characterization	NN
cord-287853-cob7ur35	122	103	of	of	IN
cord-287853-cob7ur35	122	104	potential	potential	JJ
cord-287853-cob7ur35	122	105	glycosylation	glycosylation	NN
cord-287853-cob7ur35	122	106	sites	site	NNS
cord-287853-cob7ur35	122	107	of	of	IN
cord-287853-cob7ur35	122	108	the	the	DT
cord-287853-cob7ur35	122	109	type	type	NN
cord-287853-cob7ur35	122	110	1	1	CD
cord-287853-cob7ur35	122	111	recombinant	recombinant	JJ
cord-287853-cob7ur35	122	112	human	human	JJ
cord-287853-cob7ur35	122	113	immunodeficiency	immunodeficiency	NN
cord-287853-cob7ur35	122	114	virus	virus	NN
cord-287853-cob7ur35	122	115	envelope	envelope	NN
cord-287853-cob7ur35	122	116	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	122	117	(	(	-LRB-
cord-287853-cob7ur35	122	118	gp120	gp120	NNP
cord-287853-cob7ur35	122	119	)	)	-RRB-
cord-287853-cob7ur35	122	120	expressed	express	VBN
cord-287853-cob7ur35	122	121	in	in	IN
cord-287853-cob7ur35	122	122	Chinese	chinese	JJ
cord-287853-cob7ur35	122	123	hamster	hamster	NN
cord-287853-cob7ur35	122	124	ovary	ovary	NN
cord-287853-cob7ur35	122	125	cells	cell	VBZ
cord-287853-cob7ur35	122	126	Comparison	comparison	NN
cord-287853-cob7ur35	122	127	of	of	IN
cord-287853-cob7ur35	122	128	HPLC	HPLC	NNP
cord-287853-cob7ur35	122	129	/	/	SYM
cord-287853-cob7ur35	122	130	ESI	ESI	NNP
cord-287853-cob7ur35	122	131	-	-	HYPH
cord-287853-cob7ur35	122	132	FTICR	FTICR	NNP
cord-287853-cob7ur35	122	133	MS	MS	NNP
cord-287853-cob7ur35	122	134	versus	versus	IN
cord-287853-cob7ur35	122	135	MALDI	MALDI	NNP
cord-287853-cob7ur35	122	136	-	-	HYPH
cord-287853-cob7ur35	122	137	TOF	TOF	NNP
cord-287853-cob7ur35	122	138	/	/	SYM
cord-287853-cob7ur35	122	139	TOF	TOF	NNP
cord-287853-cob7ur35	122	140	MS	MS	NNP
cord-287853-cob7ur35	122	141	for	for	IN
cord-287853-cob7ur35	122	142	glycopeptide	glycopeptide	NNP
cord-287853-cob7ur35	122	143	analysis	analysis	NN
cord-287853-cob7ur35	122	144	of	of	IN
cord-287853-cob7ur35	122	145	a	a	DT
cord-287853-cob7ur35	122	146	highly	highly	RB
cord-287853-cob7ur35	122	147	glycosylated	glycosylated	JJ
cord-287853-cob7ur35	122	148	HIV	HIV	NNP
cord-287853-cob7ur35	122	149	envelope	envelope	NN
cord-287853-cob7ur35	122	150	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	122	151	Glycosylation	Glycosylation	NNP
cord-287853-cob7ur35	122	152	site	site	NN
cord-287853-cob7ur35	122	153	-	-	HYPH
cord-287853-cob7ur35	122	154	specific	specific	JJ
cord-287853-cob7ur35	122	155	analysis	analysis	NN
cord-287853-cob7ur35	122	156	of	of	IN
cord-287853-cob7ur35	122	157	HIV	HIV	NNP
cord-287853-cob7ur35	122	158	envelope	envelope	NN
cord-287853-cob7ur35	122	159	proteins	protein	NNS
cord-287853-cob7ur35	122	160	(	(	-LRB-
cord-287853-cob7ur35	122	161	JR	JR	NNP
cord-287853-cob7ur35	122	162	-	-	HYPH
cord-287853-cob7ur35	122	163	FL	FL	NNP
cord-287853-cob7ur35	122	164	and	and	CC
cord-287853-cob7ur35	122	165	CON	CON	NNP
cord-287853-cob7ur35	122	166	-	-	HYPH
cord-287853-cob7ur35	122	167	S	S	NNP
cord-287853-cob7ur35	122	168	)	)	-RRB-
cord-287853-cob7ur35	122	169	reveals	reveal	VBZ
cord-287853-cob7ur35	122	170	major	major	JJ
cord-287853-cob7ur35	122	171	differences	difference	NNS
cord-287853-cob7ur35	122	172	in	in	IN
cord-287853-cob7ur35	122	173	glycosylation	glycosylation	NN
cord-287853-cob7ur35	122	174	site	site	NN
cord-287853-cob7ur35	122	175	occupancy	occupancy	NN
cord-287853-cob7ur35	122	176	,	,	,
cord-287853-cob7ur35	122	177	glycoform	glycoform	NNP
cord-287853-cob7ur35	122	178	profiles	profile	NNS
cord-287853-cob7ur35	122	179	,	,	,
cord-287853-cob7ur35	122	180	and	and	CC
cord-287853-cob7ur35	122	181	antigenic	antigenic	JJ
cord-287853-cob7ur35	122	182	epitopesʼ	epitopesʼ	NN
cord-287853-cob7ur35	122	183	accessibility	accessibility	NN
cord-287853-cob7ur35	122	184	Glycosylation	Glycosylation	NNP
cord-287853-cob7ur35	122	185	site	site	NN
cord-287853-cob7ur35	122	186	-	-	HYPH
cord-287853-cob7ur35	122	187	specific	specific	JJ
cord-287853-cob7ur35	122	188	analysis	analysis	NN
cord-287853-cob7ur35	122	189	of	of	IN
cord-287853-cob7ur35	122	190	clade	clade	NN
cord-287853-cob7ur35	122	191	C	C	NNP
cord-287853-cob7ur35	122	192	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	122	193	envelope	envelope	NN
cord-287853-cob7ur35	122	194	proteins	protein	NNS
cord-287853-cob7ur35	122	195	Characterization	characterization	NN
cord-287853-cob7ur35	122	196	of	of	IN
cord-287853-cob7ur35	122	197	glycosylation	glycosylation	NN
cord-287853-cob7ur35	122	198	profiles	profile	NNS
cord-287853-cob7ur35	122	199	of	of	IN
cord-287853-cob7ur35	122	200	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	122	201	transmitted	transmit	VBD
cord-287853-cob7ur35	122	202	/	/	SYM
cord-287853-cob7ur35	122	203	founder	founder	NN
cord-287853-cob7ur35	122	204	envelopes	envelope	NNS
cord-287853-cob7ur35	122	205	by	by	IN
cord-287853-cob7ur35	122	206	mass	mass	NN
cord-287853-cob7ur35	122	207	spectrometry	spectrometry	NN
cord-287853-cob7ur35	122	208	Methods	method	NNS
cord-287853-cob7ur35	122	209	development	development	NN
cord-287853-cob7ur35	122	210	for	for	IN
cord-287853-cob7ur35	122	211	analysis	analysis	NN
cord-287853-cob7ur35	122	212	of	of	IN
cord-287853-cob7ur35	122	213	partially	partially	RB
cord-287853-cob7ur35	122	214	deglycosylated	deglycosylate	VBN
cord-287853-cob7ur35	122	215	proteins	protein	NNS
cord-287853-cob7ur35	122	216	and	and	CC
cord-287853-cob7ur35	122	217	application	application	NN
cord-287853-cob7ur35	122	218	to	to	IN
cord-287853-cob7ur35	122	219	an	an	DT
cord-287853-cob7ur35	122	220	HIV	HIV	NNP
cord-287853-cob7ur35	122	221	envelope	envelope	NN
cord-287853-cob7ur35	122	222	protein	protein	NN
cord-287853-cob7ur35	122	223	vaccine	vaccine	NN
cord-287853-cob7ur35	122	224	candidate	candidate	NN
cord-287853-cob7ur35	122	225	Analysis	Analysis	NNP
cord-287853-cob7ur35	122	226	of	of	IN
cord-287853-cob7ur35	122	227	the	the	DT
cord-287853-cob7ur35	122	228	disulfide	disulfide	JJ
cord-287853-cob7ur35	122	229	bond	bond	NN
cord-287853-cob7ur35	122	230	arrangement	arrangement	NN
cord-287853-cob7ur35	122	231	of	of	IN
cord-287853-cob7ur35	122	232	the	the	DT
cord-287853-cob7ur35	122	233	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	122	234	envelope	envelope	NN
cord-287853-cob7ur35	122	235	protein	protein	NN
cord-287853-cob7ur35	122	236	CON	con	NN
cord-287853-cob7ur35	122	237	-	-	HYPH
cord-287853-cob7ur35	122	238	S	S	NNP
cord-287853-cob7ur35	122	239	gp140	gp140	NN
cord-287853-cob7ur35	123	1	ΔCFI	ΔCFI	NNP
cord-287853-cob7ur35	123	2	shows	show	VBZ
cord-287853-cob7ur35	123	3	variability	variability	NN
cord-287853-cob7ur35	123	4	in	in	IN
cord-287853-cob7ur35	123	5	the	the	DT
cord-287853-cob7ur35	123	6	V1	v1	NN
cord-287853-cob7ur35	123	7	and	and	CC
cord-287853-cob7ur35	123	8	V2	v2	NN
cord-287853-cob7ur35	123	9	regions	region	NNS
cord-287853-cob7ur35	123	10	Characterization	characterization	NN
cord-287853-cob7ur35	123	11	of	of	IN
cord-287853-cob7ur35	123	12	host	host	NN
cord-287853-cob7ur35	123	13	-	-	HYPH
cord-287853-cob7ur35	123	14	cell	cell	NN
cord-287853-cob7ur35	123	15	line	line	NN
cord-287853-cob7ur35	123	16	specific	specific	JJ
cord-287853-cob7ur35	123	17	glycosylation	glycosylation	NN
cord-287853-cob7ur35	123	18	profiles	profile	NNS
cord-287853-cob7ur35	123	19	of	of	IN
cord-287853-cob7ur35	123	20	early	early	RB
cord-287853-cob7ur35	123	21	transmitted	transmit	VBN
cord-287853-cob7ur35	123	22	/	/	SYM
cord-287853-cob7ur35	123	23	founder	founder	NN
cord-287853-cob7ur35	123	24	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	123	25	gp120	gp120	NNP
cord-287853-cob7ur35	123	26	envelope	envelope	NN
cord-287853-cob7ur35	123	27	proteins	protein	NNS
cord-287853-cob7ur35	124	1	Glycosylation	glycosylation	NN
cord-287853-cob7ur35	124	2	and	and	CC
cord-287853-cob7ur35	124	3	disulfide	disulfide	JJ
cord-287853-cob7ur35	124	4	bond	bond	NN
cord-287853-cob7ur35	124	5	analysis	analysis	NN
cord-287853-cob7ur35	124	6	of	of	IN
cord-287853-cob7ur35	124	7	transiently	transiently	RB
cord-287853-cob7ur35	124	8	and	and	CC
cord-287853-cob7ur35	124	9	stably	stably	RB
cord-287853-cob7ur35	124	10	expressed	express	VBD
cord-287853-cob7ur35	124	11	clade	clade	NN
cord-287853-cob7ur35	124	12	C	C	NNP
cord-287853-cob7ur35	124	13	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	124	14	gp140	gp140	DT
cord-287853-cob7ur35	124	15	trimers	trimer	NNS
cord-287853-cob7ur35	124	16	in	in	IN
cord-287853-cob7ur35	124	17	293	293	CD
cord-287853-cob7ur35	124	18	T	T	NNP
cord-287853-cob7ur35	124	19	cells	cell	NNS
cord-287853-cob7ur35	124	20	identifies	identify	VBZ
cord-287853-cob7ur35	124	21	disulfide	disulfide	JJ
cord-287853-cob7ur35	124	22	heterogeneity	heterogeneity	NN
cord-287853-cob7ur35	124	23	present	present	JJ
cord-287853-cob7ur35	124	24	in	in	IN
cord-287853-cob7ur35	124	25	both	both	DT
cord-287853-cob7ur35	124	26	proteins	protein	NNS
cord-287853-cob7ur35	124	27	and	and	CC
cord-287853-cob7ur35	124	28	differences	difference	NNS
cord-287853-cob7ur35	124	29	in	in	IN
cord-287853-cob7ur35	124	30	O	o	NN
cord-287853-cob7ur35	124	31	-	-	HYPH
cord-287853-cob7ur35	124	32	linked	link	VBN
cord-287853-cob7ur35	124	33	glycosylation	glycosylation	NN
cord-287853-cob7ur35	124	34	Influences	influence	NNS
cord-287853-cob7ur35	124	35	on	on	IN
cord-287853-cob7ur35	124	36	the	the	DT
cord-287853-cob7ur35	124	37	design	design	NN
cord-287853-cob7ur35	124	38	and	and	CC
cord-287853-cob7ur35	124	39	purification	purification	NN
cord-287853-cob7ur35	124	40	of	of	IN
cord-287853-cob7ur35	124	41	soluble	soluble	JJ
cord-287853-cob7ur35	124	42	,	,	,
cord-287853-cob7ur35	124	43	recombinant	recombinant	JJ
cord-287853-cob7ur35	124	44	native	native	JJ
cord-287853-cob7ur35	124	45	-	-	HYPH
cord-287853-cob7ur35	124	46	like	like	JJ
cord-287853-cob7ur35	124	47	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	124	48	envelope	envelope	NN
cord-287853-cob7ur35	124	49	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	124	50	trimers	trimer	VBZ
cord-287853-cob7ur35	124	51	Generation	Generation	NNP
cord-287853-cob7ur35	124	52	and	and	CC
cord-287853-cob7ur35	124	53	characterization	characterization	NN
cord-287853-cob7ur35	124	54	of	of	IN
cord-287853-cob7ur35	124	55	a	a	DT
cord-287853-cob7ur35	124	56	bivalent	bivalent	JJ
cord-287853-cob7ur35	124	57	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	124	58	subtype	subtype	NN
cord-287853-cob7ur35	124	59	C	C	NNP
cord-287853-cob7ur35	124	60	gp120	gp120	NNP
cord-287853-cob7ur35	124	61	protein	protein	NN
cord-287853-cob7ur35	124	62	boost	boost	NN
cord-287853-cob7ur35	124	63	for	for	IN
cord-287853-cob7ur35	124	64	proof	proof	NN
cord-287853-cob7ur35	124	65	-	-	HYPH
cord-287853-cob7ur35	124	66	ofconcept	ofconcept	JJ
cord-287853-cob7ur35	124	67	HIV	HIV	NNP
cord-287853-cob7ur35	124	68	vaccine	vaccine	NN
cord-287853-cob7ur35	124	69	efficacy	efficacy	NN
cord-287853-cob7ur35	124	70	trials	trial	NNS
cord-287853-cob7ur35	124	71	in	in	IN
cord-287853-cob7ur35	124	72	Southern	Southern	NNP
cord-287853-cob7ur35	124	73	Africa	Africa	NNP
cord-287853-cob7ur35	124	74	Glycosylation	Glycosylation	NNP
cord-287853-cob7ur35	124	75	benchmark	benchmark	NN
cord-287853-cob7ur35	124	76	profile	profile	NN
cord-287853-cob7ur35	124	77	for	for	IN
cord-287853-cob7ur35	124	78	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	124	79	envelope	envelope	NN
cord-287853-cob7ur35	124	80	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	124	81	production	production	NN
cord-287853-cob7ur35	124	82	based	base	VBN
cord-287853-cob7ur35	124	83	on	on	IN
cord-287853-cob7ur35	124	84	eleven	eleven	CD
cord-287853-cob7ur35	124	85	Env	Env	NNP
cord-287853-cob7ur35	124	86	trimers	trimers	NNP
cord-287853-cob7ur35	124	87	Cell	cell	NN
cord-287853-cob7ur35	124	88	-	-	,
cord-287853-cob7ur35	124	89	and	and	CC
cord-287853-cob7ur35	124	90	protein	protein	NN
cord-287853-cob7ur35	124	91	-	-	HYPH
cord-287853-cob7ur35	124	92	directed	direct	VBN
cord-287853-cob7ur35	124	93	glycosylation	glycosylation	NN
cord-287853-cob7ur35	124	94	of	of	IN
cord-287853-cob7ur35	124	95	native	native	JJ
cord-287853-cob7ur35	124	96	cleaved	cleave	VBD
cord-287853-cob7ur35	124	97	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	124	98	envelope	envelope	NN
cord-287853-cob7ur35	124	99	Composition	composition	NN
cord-287853-cob7ur35	124	100	and	and	CC
cord-287853-cob7ur35	124	101	antigenic	antigenic	JJ
cord-287853-cob7ur35	124	102	effects	effect	NNS
cord-287853-cob7ur35	124	103	of	of	IN
cord-287853-cob7ur35	124	104	individual	individual	JJ
cord-287853-cob7ur35	124	105	glycan	glycan	NN
cord-287853-cob7ur35	124	106	sites	site	NNS
cord-287853-cob7ur35	124	107	of	of	IN
cord-287853-cob7ur35	124	108	a	a	DT
cord-287853-cob7ur35	124	109	trimeric	trimeric	NNP
cord-287853-cob7ur35	124	110	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	124	111	envelope	envelope	NN
cord-287853-cob7ur35	124	112	glycoprotein	glycoprotein	VBG
cord-287853-cob7ur35	124	113	Molecular	molecular	JJ
cord-287853-cob7ur35	124	114	architecture	architecture	NN
cord-287853-cob7ur35	124	115	of	of	IN
cord-287853-cob7ur35	124	116	the	the	DT
cord-287853-cob7ur35	124	117	cleavage	cleavage	NN
cord-287853-cob7ur35	124	118	-	-	HYPH
cord-287853-cob7ur35	124	119	dependent	dependent	JJ
cord-287853-cob7ur35	124	120	mannose	mannose	NN
cord-287853-cob7ur35	124	121	patch	patch	NN
cord-287853-cob7ur35	124	122	on	on	IN
cord-287853-cob7ur35	124	123	a	a	DT
cord-287853-cob7ur35	124	124	soluble	soluble	JJ
cord-287853-cob7ur35	124	125	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	124	126	envelope	envelope	NN
cord-287853-cob7ur35	124	127	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	124	128	trimer	trimer	NN
cord-287853-cob7ur35	124	129	Glycosylation	Glycosylation	NNP
cord-287853-cob7ur35	124	130	profiling	profile	VBG
cord-287853-cob7ur35	124	131	to	to	TO
cord-287853-cob7ur35	124	132	evaluate	evaluate	VB
cord-287853-cob7ur35	124	133	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	124	134	immunogens	immunogen	NNS
cord-287853-cob7ur35	124	135	against	against	IN
cord-287853-cob7ur35	124	136	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	124	137	Envelope	Envelope	NNP
cord-287853-cob7ur35	124	138	glycans	glycan	NNS
cord-287853-cob7ur35	124	139	of	of	IN
cord-287853-cob7ur35	124	140	immunodeficiency	immunodeficiency	NN
cord-287853-cob7ur35	124	141	virions	virion	NNS
cord-287853-cob7ur35	124	142	are	be	VBP
cord-287853-cob7ur35	124	143	almost	almost	RB
cord-287853-cob7ur35	124	144	entirely	entirely	RB
cord-287853-cob7ur35	124	145	oligomannose	oligomannose	NN
cord-287853-cob7ur35	124	146	antigens	antigen	NNS
cord-287853-cob7ur35	124	147	The	the	DT
cord-287853-cob7ur35	124	148	glycan	glycan	NN
cord-287853-cob7ur35	124	149	shield	shield	NN
cord-287853-cob7ur35	124	150	of	of	IN
cord-287853-cob7ur35	124	151	HIV	HIV	NNP
cord-287853-cob7ur35	124	152	is	be	VBZ
cord-287853-cob7ur35	124	153	predominantly	predominantly	RB
cord-287853-cob7ur35	124	154	oligomannose	oligomannose	JJ
cord-287853-cob7ur35	124	155	independently	independently	RB
cord-287853-cob7ur35	124	156	of	of	IN
cord-287853-cob7ur35	124	157	production	production	NN
cord-287853-cob7ur35	124	158	system	system	NN
cord-287853-cob7ur35	124	159	or	or	CC
cord-287853-cob7ur35	124	160	viral	viral	JJ
cord-287853-cob7ur35	124	161	clade	clade	NN
cord-287853-cob7ur35	125	1	Structural	structural	JJ
cord-287853-cob7ur35	125	2	constraints	constraint	NNS
cord-287853-cob7ur35	125	3	determine	determine	VBP
cord-287853-cob7ur35	125	4	the	the	DT
cord-287853-cob7ur35	125	5	glycosylation	glycosylation	NN
cord-287853-cob7ur35	125	6	of	of	IN
cord-287853-cob7ur35	125	7	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	125	8	envelope	envelope	NN
cord-287853-cob7ur35	125	9	trimers	trimer	NNS
cord-287853-cob7ur35	125	10	Ion	ion	IN
cord-287853-cob7ur35	125	11	mobility	mobility	NN
cord-287853-cob7ur35	125	12	mass	mass	NN
cord-287853-cob7ur35	125	13	spectrometry	spectrometry	NN
cord-287853-cob7ur35	125	14	for	for	IN
cord-287853-cob7ur35	125	15	extracting	extract	VBG
cord-287853-cob7ur35	125	16	spectra	spectrum	NNS
cord-287853-cob7ur35	125	17	of	of	IN
cord-287853-cob7ur35	125	18	N	n	NN
cord-287853-cob7ur35	125	19	-	-	HYPH
cord-287853-cob7ur35	125	20	glycans	glycan	NNS
cord-287853-cob7ur35	125	21	directly	directly	RB
cord-287853-cob7ur35	125	22	from	from	IN
cord-287853-cob7ur35	125	23	incubation	incubation	NN
cord-287853-cob7ur35	125	24	mixtures	mixture	NNS
cord-287853-cob7ur35	125	25	following	follow	VBG
cord-287853-cob7ur35	125	26	glycan	glycan	NN
cord-287853-cob7ur35	125	27	release	release	NN
cord-287853-cob7ur35	125	28	:	:	:
cord-287853-cob7ur35	125	29	application	application	NN
cord-287853-cob7ur35	125	30	to	to	IN
cord-287853-cob7ur35	125	31	glycans	glycan	NNS
cord-287853-cob7ur35	125	32	from	from	IN
cord-287853-cob7ur35	125	33	engineered	engineer	VBN
cord-287853-cob7ur35	125	34	glycoforms	glycoform	NNS
cord-287853-cob7ur35	125	35	of	of	IN
cord-287853-cob7ur35	125	36	intact	intact	JJ
cord-287853-cob7ur35	125	37	,	,	,
cord-287853-cob7ur35	125	38	folded	fold	VBD
cord-287853-cob7ur35	125	39	HIV	HIV	NNP
cord-287853-cob7ur35	126	1	gp120	gp120	NNP
cord-287853-cob7ur35	126	2	MALDI	MALDI	NNP
cord-287853-cob7ur35	126	3	-	-	HYPH
cord-287853-cob7ur35	126	4	MS	MS	NNP
cord-287853-cob7ur35	126	5	/	/	SYM
cord-287853-cob7ur35	126	6	MS	MS	NNP
cord-287853-cob7ur35	126	7	with	with	IN
cord-287853-cob7ur35	126	8	traveling	travel	VBG
cord-287853-cob7ur35	126	9	wave	wave	NN
cord-287853-cob7ur35	126	10	ion	ion	NN
cord-287853-cob7ur35	126	11	mobility	mobility	NN
cord-287853-cob7ur35	126	12	for	for	IN
cord-287853-cob7ur35	126	13	the	the	DT
cord-287853-cob7ur35	126	14	structural	structural	JJ
cord-287853-cob7ur35	126	15	analysis	analysis	NN
cord-287853-cob7ur35	126	16	of	of	IN
cord-287853-cob7ur35	126	17	N	n	NN
cord-287853-cob7ur35	126	18	-	-	HYPH
cord-287853-cob7ur35	126	19	linked	link	VBN
cord-287853-cob7ur35	126	20	glycans	glycan	NNS
cord-287853-cob7ur35	126	21	Ion	ion	IN
cord-287853-cob7ur35	126	22	mobility	mobility	NN
cord-287853-cob7ur35	126	23	mass	mass	NN
cord-287853-cob7ur35	126	24	spectrometry	spectrometry	NN
cord-287853-cob7ur35	126	25	for	for	IN
cord-287853-cob7ur35	126	26	ion	ion	NN
cord-287853-cob7ur35	126	27	recovery	recovery	NN
cord-287853-cob7ur35	126	28	and	and	CC
cord-287853-cob7ur35	126	29	clean	clean	JJ
cord-287853-cob7ur35	126	30	-	-	HYPH
cord-287853-cob7ur35	126	31	up	up	NN
cord-287853-cob7ur35	126	32	of	of	IN
cord-287853-cob7ur35	126	33	MS	MS	NNP
cord-287853-cob7ur35	126	34	and	and	CC
cord-287853-cob7ur35	126	35	MS	MS	NNP
cord-287853-cob7ur35	126	36	/	/	SYM
cord-287853-cob7ur35	126	37	MS	MS	NNP
cord-287853-cob7ur35	126	38	spectra	spectra	NNP
cord-287853-cob7ur35	126	39	obtained	obtain	VBN
cord-287853-cob7ur35	126	40	from	from	IN
cord-287853-cob7ur35	126	41	low	low	JJ
cord-287853-cob7ur35	126	42	abundance	abundance	NN
cord-287853-cob7ur35	126	43	viral	viral	JJ
cord-287853-cob7ur35	126	44	samples	sample	NNS
cord-287853-cob7ur35	126	45	Global	Global	NNP
cord-287853-cob7ur35	126	46	Nglycan	nglycan	JJ
cord-287853-cob7ur35	126	47	site	site	NN
cord-287853-cob7ur35	126	48	occupancy	occupancy	NN
cord-287853-cob7ur35	126	49	of	of	IN
cord-287853-cob7ur35	126	50	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	126	51	gp120	gp120	NNP
cord-287853-cob7ur35	126	52	by	by	IN
cord-287853-cob7ur35	126	53	metabolic	metabolic	JJ
cord-287853-cob7ur35	126	54	engineering	engineering	NN
cord-287853-cob7ur35	126	55	and	and	CC
cord-287853-cob7ur35	126	56	high	high	JJ
cord-287853-cob7ur35	126	57	-	-	HYPH
cord-287853-cob7ur35	126	58	resolution	resolution	NN
cord-287853-cob7ur35	127	1	intact	intact	JJ
cord-287853-cob7ur35	127	2	mass	mass	NN
cord-287853-cob7ur35	127	3	spectrometry	spectrometry	NN
cord-287853-cob7ur35	127	4	Structural	structural	JJ
cord-287853-cob7ur35	127	5	principles	principle	NNS
cord-287853-cob7ur35	127	6	controlling	control	VBG
cord-287853-cob7ur35	127	7	HIV	HIV	NNP
cord-287853-cob7ur35	127	8	envelope	envelope	NN
cord-287853-cob7ur35	127	9	glycosylation	glycosylation	NN
cord-287853-cob7ur35	127	10	Global	global	JJ
cord-287853-cob7ur35	127	11	site	site	NN
cord-287853-cob7ur35	127	12	-	-	HYPH
cord-287853-cob7ur35	127	13	specific	specific	JJ
cord-287853-cob7ur35	127	14	Nglycosylation	Nglycosylation	NNP
cord-287853-cob7ur35	127	15	analysis	analysis	NN
cord-287853-cob7ur35	127	16	of	of	IN
cord-287853-cob7ur35	127	17	HIV	HIV	NNP
cord-287853-cob7ur35	127	18	envelope	envelope	NN
cord-287853-cob7ur35	127	19	glycoprotein	glycoprotein	VBG
cord-287853-cob7ur35	127	20	Comprehensive	comprehensive	JJ
cord-287853-cob7ur35	127	21	characterization	characterization	NN
cord-287853-cob7ur35	127	22	of	of	IN
cord-287853-cob7ur35	127	23	reference	reference	NN
cord-287853-cob7ur35	127	24	standard	standard	JJ
cord-287853-cob7ur35	127	25	lots	lot	NNS
cord-287853-cob7ur35	127	26	of	of	IN
cord-287853-cob7ur35	127	27	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	127	28	subtype	subtype	NN
cord-287853-cob7ur35	127	29	C	c	NN
cord-287853-cob7ur35	127	30	Gp120	gp120	NN
cord-287853-cob7ur35	127	31	proteins	protein	NNS
cord-287853-cob7ur35	127	32	for	for	IN
cord-287853-cob7ur35	127	33	clinical	clinical	JJ
cord-287853-cob7ur35	127	34	trials	trial	NNS
cord-287853-cob7ur35	127	35	in	in	IN
cord-287853-cob7ur35	127	36	Southern	southern	JJ
cord-287853-cob7ur35	127	37	African	african	JJ
cord-287853-cob7ur35	127	38	regions	region	NNS
cord-287853-cob7ur35	127	39	Cell	cell	NN
cord-287853-cob7ur35	127	40	culture	culture	NN
cord-287853-cob7ur35	127	41	as	as	IN
cord-287853-cob7ur35	127	42	a	a	DT
cord-287853-cob7ur35	127	43	substrate	substrate	NN
cord-287853-cob7ur35	127	44	for	for	IN
cord-287853-cob7ur35	127	45	the	the	DT
cord-287853-cob7ur35	127	46	production	production	NN
cord-287853-cob7ur35	127	47	of	of	IN
cord-287853-cob7ur35	127	48	influenza	influenza	NN
cord-287853-cob7ur35	127	49	vaccines	vaccine	NNS
cord-287853-cob7ur35	128	1	:	:	:
cord-287853-cob7ur35	128	2	memorandum	memorandum	NN
cord-287853-cob7ur35	128	3	from	from	IN
cord-287853-cob7ur35	128	4	a	a	DT
cord-287853-cob7ur35	128	5	WHO	WHO	NNP
cord-287853-cob7ur35	128	6	meeting	meeting	NN
cord-287853-cob7ur35	128	7	Current	current	JJ
cord-287853-cob7ur35	128	8	and	and	CC
cord-287853-cob7ur35	128	9	emerging	emerge	VBG
cord-287853-cob7ur35	128	10	cell	cell	NN
cord-287853-cob7ur35	128	11	culture	culture	NN
cord-287853-cob7ur35	128	12	manufacturing	manufacturing	NN
cord-287853-cob7ur35	128	13	technologies	technology	NNS
cord-287853-cob7ur35	128	14	for	for	IN
cord-287853-cob7ur35	128	15	influenza	influenza	NN
cord-287853-cob7ur35	128	16	vaccines	vaccine	NNS
cord-287853-cob7ur35	128	17	Critical	critical	JJ
cord-287853-cob7ur35	128	18	review	review	NN
cord-287853-cob7ur35	128	19	of	of	IN
cord-287853-cob7ur35	128	20	current	current	JJ
cord-287853-cob7ur35	128	21	and	and	CC
cord-287853-cob7ur35	128	22	emerging	emerge	VBG
cord-287853-cob7ur35	128	23	quantification	quantification	NN
cord-287853-cob7ur35	128	24	methods	method	NNS
cord-287853-cob7ur35	128	25	for	for	IN
cord-287853-cob7ur35	128	26	the	the	DT
cord-287853-cob7ur35	128	27	development	development	NN
cord-287853-cob7ur35	128	28	of	of	IN
cord-287853-cob7ur35	128	29	influenza	influenza	NN
cord-287853-cob7ur35	128	30	vaccine	vaccine	NN
cord-287853-cob7ur35	128	31	candidates	candidate	NNS
cord-287853-cob7ur35	128	32	Influenza	Influenza	NNP
cord-287853-cob7ur35	128	33	vaccine	vaccine	NN
cord-287853-cob7ur35	128	34	:	:	:
cord-287853-cob7ur35	128	35	the	the	DT
cord-287853-cob7ur35	128	36	challenge	challenge	NN
cord-287853-cob7ur35	128	37	of	of	IN
cord-287853-cob7ur35	128	38	antigenic	antigenic	JJ
cord-287853-cob7ur35	128	39	drift	drift	NN
cord-287853-cob7ur35	128	40	Confronting	confront	VBG
cord-287853-cob7ur35	128	41	the	the	DT
cord-287853-cob7ur35	128	42	next	next	JJ
cord-287853-cob7ur35	128	43	pandemic	pandemic	NN
cord-287853-cob7ur35	128	44	-	-	HYPH
cord-287853-cob7ur35	128	45	workshop	workshop	NN
cord-287853-cob7ur35	128	46	on	on	IN
cord-287853-cob7ur35	128	47	lessons	lesson	NNS
cord-287853-cob7ur35	128	48	learned	learn	VBN
cord-287853-cob7ur35	128	49	from	from	IN
cord-287853-cob7ur35	128	50	potency	potency	NN
cord-287853-cob7ur35	128	51	testing	testing	NN
cord-287853-cob7ur35	128	52	of	of	IN
cord-287853-cob7ur35	128	53	pandemic	pandemic	NN
cord-287853-cob7ur35	128	54	(	(	-LRB-
cord-287853-cob7ur35	128	55	H1N1	H1N1	NNP
cord-287853-cob7ur35	128	56	)	)	-RRB-
cord-287853-cob7ur35	129	1	2009	2009	CD
cord-287853-cob7ur35	129	2	influenza	influenza	NN
cord-287853-cob7ur35	129	3	vaccines	vaccine	NNS
cord-287853-cob7ur35	129	4	and	and	CC
cord-287853-cob7ur35	129	5	considerations	consideration	NNS
cord-287853-cob7ur35	129	6	for	for	IN
cord-287853-cob7ur35	129	7	future	future	JJ
cord-287853-cob7ur35	129	8	potency	potency	NN
cord-287853-cob7ur35	129	9	tests	test	NNS
cord-287853-cob7ur35	129	10	Application	Application	NNP
cord-287853-cob7ur35	129	11	of	of	IN
cord-287853-cob7ur35	129	12	deglycosylation	deglycosylation	NN
cord-287853-cob7ur35	129	13	and	and	CC
cord-287853-cob7ur35	129	14	electrophoresis	electrophoresis	NN
cord-287853-cob7ur35	129	15	to	to	IN
cord-287853-cob7ur35	129	16	the	the	DT
cord-287853-cob7ur35	129	17	quantification	quantification	NN
cord-287853-cob7ur35	129	18	of	of	IN
cord-287853-cob7ur35	129	19	influenza	influenza	JJ
cord-287853-cob7ur35	129	20	viral	viral	JJ
cord-287853-cob7ur35	129	21	hemagglutinins	hemagglutinin	NNS
cord-287853-cob7ur35	129	22	facilitating	facilitate	VBG
cord-287853-cob7ur35	129	23	the	the	DT
cord-287853-cob7ur35	129	24	production	production	NN
cord-287853-cob7ur35	129	25	of	of	IN
cord-287853-cob7ur35	129	26	2009	2009	CD
cord-287853-cob7ur35	129	27	pandemic	pandemic	NN
cord-287853-cob7ur35	129	28	influenza	influenza	NN
cord-287853-cob7ur35	129	29	(	(	-LRB-
cord-287853-cob7ur35	129	30	H1N1	H1N1	NNP
cord-287853-cob7ur35	129	31	)	)	-RRB-
cord-287853-cob7ur35	129	32	vaccines	vaccine	NNS
cord-287853-cob7ur35	129	33	at	at	IN
cord-287853-cob7ur35	129	34	multiple	multiple	JJ
cord-287853-cob7ur35	129	35	manufacturing	manufacturing	NN
cord-287853-cob7ur35	129	36	sites	site	NNS
cord-287853-cob7ur35	129	37	in	in	IN
cord-287853-cob7ur35	129	38	China	China	NNP
cord-287853-cob7ur35	129	39	Quantification	Quantification	NNP
cord-287853-cob7ur35	129	40	of	of	IN
cord-287853-cob7ur35	129	41	influenza	influenza	NN
cord-287853-cob7ur35	129	42	virus	virus	NN
cord-287853-cob7ur35	130	1	hemagglutinins	hemagglutinins	NNP
cord-287853-cob7ur35	130	2	in	in	IN
cord-287853-cob7ur35	130	3	complex	complex	JJ
cord-287853-cob7ur35	130	4	mixtures	mixture	NNS
cord-287853-cob7ur35	130	5	using	use	VBG
cord-287853-cob7ur35	130	6	isotope	isotope	NN
cord-287853-cob7ur35	130	7	dilution	dilution	NN
cord-287853-cob7ur35	130	8	tandem	tandem	NN
cord-287853-cob7ur35	130	9	mass	mass	NN
cord-287853-cob7ur35	130	10	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	11	Optimization	optimization	NN
cord-287853-cob7ur35	130	12	of	of	IN
cord-287853-cob7ur35	130	13	digestion	digestion	NN
cord-287853-cob7ur35	130	14	parameters	parameter	NNS
cord-287853-cob7ur35	130	15	for	for	IN
cord-287853-cob7ur35	130	16	protein	protein	NN
cord-287853-cob7ur35	130	17	quantification	quantification	NN
cord-287853-cob7ur35	130	18	Simultaneous	simultaneous	JJ
cord-287853-cob7ur35	130	19	quantification	quantification	NN
cord-287853-cob7ur35	130	20	of	of	IN
cord-287853-cob7ur35	130	21	hemagglutinin	hemagglutinin	NN
cord-287853-cob7ur35	130	22	and	and	CC
cord-287853-cob7ur35	130	23	neuraminidase	neuraminidase	NN
cord-287853-cob7ur35	130	24	of	of	IN
cord-287853-cob7ur35	130	25	influenza	influenza	NN
cord-287853-cob7ur35	130	26	virus	virus	NN
cord-287853-cob7ur35	130	27	using	use	VBG
cord-287853-cob7ur35	130	28	isotope	isotope	NN
cord-287853-cob7ur35	130	29	dilution	dilution	NN
cord-287853-cob7ur35	130	30	mass	mass	NN
cord-287853-cob7ur35	130	31	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	32	Quantification	quantification	NN
cord-287853-cob7ur35	130	33	of	of	IN
cord-287853-cob7ur35	130	34	viral	viral	JJ
cord-287853-cob7ur35	130	35	proteins	protein	NNS
cord-287853-cob7ur35	130	36	of	of	IN
cord-287853-cob7ur35	130	37	the	the	DT
cord-287853-cob7ur35	130	38	avian	avian	JJ
cord-287853-cob7ur35	130	39	H7	H7	NNP
cord-287853-cob7ur35	130	40	subtype	subtype	NN
cord-287853-cob7ur35	130	41	of	of	IN
cord-287853-cob7ur35	130	42	influenza	influenza	NN
cord-287853-cob7ur35	130	43	virus	virus	NN
cord-287853-cob7ur35	130	44	:	:	:
cord-287853-cob7ur35	130	45	an	an	DT
cord-287853-cob7ur35	130	46	isotope	isotope	NN
cord-287853-cob7ur35	130	47	dilution	dilution	NN
cord-287853-cob7ur35	130	48	mass	mass	NN
cord-287853-cob7ur35	130	49	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	50	method	method	NN
cord-287853-cob7ur35	130	51	applicable	applicable	JJ
cord-287853-cob7ur35	130	52	for	for	IN
cord-287853-cob7ur35	130	53	producing	produce	VBG
cord-287853-cob7ur35	130	54	more	more	RBR
cord-287853-cob7ur35	130	55	rapid	rapid	JJ
cord-287853-cob7ur35	130	56	vaccines	vaccine	NNS
cord-287853-cob7ur35	130	57	in	in	IN
cord-287853-cob7ur35	130	58	the	the	DT
cord-287853-cob7ur35	130	59	case	case	NN
cord-287853-cob7ur35	130	60	of	of	IN
cord-287853-cob7ur35	130	61	an	an	DT
cord-287853-cob7ur35	130	62	influenza	influenza	NN
cord-287853-cob7ur35	130	63	pandemic	pandemic	NN
cord-287853-cob7ur35	130	64	Development	Development	NNP
cord-287853-cob7ur35	130	65	of	of	IN
cord-287853-cob7ur35	130	66	influenza	influenza	NN
cord-287853-cob7ur35	130	67	A	a	NN
cord-287853-cob7ur35	130	68	(	(	-LRB-
cord-287853-cob7ur35	130	69	H7N9	H7N9	NNP
cord-287853-cob7ur35	130	70	)	)	-RRB-
cord-287853-cob7ur35	130	71	candidate	candidate	NN
cord-287853-cob7ur35	130	72	vaccine	vaccine	NN
cord-287853-cob7ur35	130	73	viruses	virus	NNS
cord-287853-cob7ur35	130	74	with	with	IN
cord-287853-cob7ur35	130	75	improved	improve	VBN
cord-287853-cob7ur35	130	76	hemagglutinin	hemagglutinin	NN
cord-287853-cob7ur35	130	77	antigen	antigen	NN
cord-287853-cob7ur35	130	78	yield	yield	NN
cord-287853-cob7ur35	130	79	in	in	IN
cord-287853-cob7ur35	130	80	eggs	egg	NNS
cord-287853-cob7ur35	130	81	Quantification	quantification	NN
cord-287853-cob7ur35	130	82	of	of	IN
cord-287853-cob7ur35	130	83	immunoreactive	immunoreactive	JJ
cord-287853-cob7ur35	130	84	viral	viral	JJ
cord-287853-cob7ur35	130	85	influenza	influenza	NN
cord-287853-cob7ur35	130	86	proteins	protein	NNS
cord-287853-cob7ur35	130	87	by	by	IN
cord-287853-cob7ur35	130	88	immunoaffinity	immunoaffinity	NN
cord-287853-cob7ur35	130	89	capture	capture	NN
cord-287853-cob7ur35	130	90	and	and	CC
cord-287853-cob7ur35	130	91	isotope	isotope	NN
cord-287853-cob7ur35	130	92	-	-	HYPH
cord-287853-cob7ur35	130	93	dilution	dilution	NN
cord-287853-cob7ur35	130	94	liquid	liquid	NN
cord-287853-cob7ur35	130	95	chromatography	chromatography	NN
cord-287853-cob7ur35	130	96	-	-	HYPH
cord-287853-cob7ur35	130	97	tandem	tandem	NN
cord-287853-cob7ur35	130	98	mass	mass	NN
cord-287853-cob7ur35	130	99	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	100	Immunocapture	Immunocapture	NNP
cord-287853-cob7ur35	130	101	isotope	isotope	NN
cord-287853-cob7ur35	130	102	dilution	dilution	NN
cord-287853-cob7ur35	130	103	mass	mass	NN
cord-287853-cob7ur35	130	104	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	105	in	in	IN
cord-287853-cob7ur35	130	106	response	response	NN
cord-287853-cob7ur35	130	107	to	to	IN
cord-287853-cob7ur35	130	108	a	a	DT
cord-287853-cob7ur35	130	109	pandemic	pandemic	NN
cord-287853-cob7ur35	130	110	influenza	influenza	NN
cord-287853-cob7ur35	130	111	threat	threat	NN
cord-287853-cob7ur35	130	112	Quantification	quantification	NN
cord-287853-cob7ur35	130	113	of	of	IN
cord-287853-cob7ur35	130	114	influenza	influenza	NN
cord-287853-cob7ur35	130	115	neuraminidase	neuraminidase	FW
cord-287853-cob7ur35	130	116	activity	activity	NN
cord-287853-cob7ur35	130	117	by	by	IN
cord-287853-cob7ur35	130	118	ultra	ultra	JJ
cord-287853-cob7ur35	130	119	-	-	JJ
cord-287853-cob7ur35	130	120	high	high	JJ
cord-287853-cob7ur35	130	121	performance	performance	NN
cord-287853-cob7ur35	130	122	liquid	liquid	NN
cord-287853-cob7ur35	130	123	chromatography	chromatography	NN
cord-287853-cob7ur35	130	124	and	and	CC
cord-287853-cob7ur35	130	125	isotope	isotope	NN
cord-287853-cob7ur35	130	126	dilution	dilution	NN
cord-287853-cob7ur35	130	127	mass	mass	NN
cord-287853-cob7ur35	130	128	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	129	Label	label	NN
cord-287853-cob7ur35	130	130	-	-	HYPH
cord-287853-cob7ur35	130	131	free	free	JJ
cord-287853-cob7ur35	130	132	mass	mass	NN
cord-287853-cob7ur35	130	133	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	134	-	-	HYPH
cord-287853-cob7ur35	130	135	based	base	VBN
cord-287853-cob7ur35	130	136	quantification	quantification	NN
cord-287853-cob7ur35	130	137	of	of	IN
cord-287853-cob7ur35	130	138	hemagglutinin	hemagglutinin	NN
cord-287853-cob7ur35	130	139	and	and	CC
cord-287853-cob7ur35	130	140	neuraminidase	neuraminidase	NN
cord-287853-cob7ur35	130	141	in	in	IN
cord-287853-cob7ur35	130	142	influenza	influenza	NN
cord-287853-cob7ur35	130	143	virus	virus	NN
cord-287853-cob7ur35	130	144	preparations	preparation	NNS
cord-287853-cob7ur35	130	145	and	and	CC
cord-287853-cob7ur35	130	146	vaccines	vaccine	NNS
cord-287853-cob7ur35	130	147	Quantification	quantification	NN
cord-287853-cob7ur35	130	148	of	of	IN
cord-287853-cob7ur35	130	149	proteins	protein	NNS
cord-287853-cob7ur35	130	150	by	by	IN
cord-287853-cob7ur35	130	151	label	label	NN
cord-287853-cob7ur35	130	152	-	-	HYPH
cord-287853-cob7ur35	130	153	free	free	JJ
cord-287853-cob7ur35	130	154	LC	LC	NNP
cord-287853-cob7ur35	130	155	-	-	HYPH
cord-287853-cob7ur35	130	156	MSE	MSE	NNP
cord-287853-cob7ur35	130	157	Absolute	absolute	JJ
cord-287853-cob7ur35	130	158	quantification	quantification	NN
cord-287853-cob7ur35	130	159	of	of	IN
cord-287853-cob7ur35	130	160	proteins	protein	NNS
cord-287853-cob7ur35	130	161	by	by	IN
cord-287853-cob7ur35	130	162	LCMS	LCMS	NNP
cord-287853-cob7ur35	130	163	E	E	NNP
cord-287853-cob7ur35	130	164	a	a	DT
cord-287853-cob7ur35	130	165	virtue	virtue	NN
cord-287853-cob7ur35	130	166	of	of	IN
cord-287853-cob7ur35	130	167	parallel	parallel	JJ
cord-287853-cob7ur35	130	168	MS	MS	NNP
cord-287853-cob7ur35	130	169	acquisition	acquisition	NN
cord-287853-cob7ur35	130	170	Selective	selective	JJ
cord-287853-cob7ur35	130	171	and	and	CC
cord-287853-cob7ur35	130	172	quantitative	quantitative	JJ
cord-287853-cob7ur35	130	173	detection	detection	NN
cord-287853-cob7ur35	130	174	of	of	IN
cord-287853-cob7ur35	130	175	influenza	influenza	NN
cord-287853-cob7ur35	130	176	virus	virus	NN
cord-287853-cob7ur35	130	177	proteins	protein	NNS
cord-287853-cob7ur35	130	178	in	in	IN
cord-287853-cob7ur35	130	179	commercial	commercial	JJ
cord-287853-cob7ur35	130	180	vaccines	vaccine	NNS
cord-287853-cob7ur35	130	181	using	use	VBG
cord-287853-cob7ur35	130	182	two	two	CD
cord-287853-cob7ur35	130	183	-	-	HYPH
cord-287853-cob7ur35	130	184	dimensional	dimensional	JJ
cord-287853-cob7ur35	130	185	high	high	JJ
cord-287853-cob7ur35	130	186	-	-	HYPH
cord-287853-cob7ur35	130	187	performance	performance	NN
cord-287853-cob7ur35	130	188	liquid	liquid	NN
cord-287853-cob7ur35	130	189	chromatography	chromatography	NN
cord-287853-cob7ur35	130	190	and	and	CC
cord-287853-cob7ur35	130	191	fluorescence	fluorescence	NN
cord-287853-cob7ur35	130	192	detection	detection	NN
cord-287853-cob7ur35	130	193	Approach	Approach	NNP
cord-287853-cob7ur35	130	194	to	to	IN
cord-287853-cob7ur35	130	195	the	the	DT
cord-287853-cob7ur35	130	196	profiling	profiling	NN
cord-287853-cob7ur35	130	197	and	and	CC
cord-287853-cob7ur35	130	198	characterization	characterization	NN
cord-287853-cob7ur35	130	199	of	of	IN
cord-287853-cob7ur35	130	200	influenza	influenza	NN
cord-287853-cob7ur35	130	201	vaccine	vaccine	NN
cord-287853-cob7ur35	130	202	constituents	constituent	NNS
cord-287853-cob7ur35	130	203	by	by	IN
cord-287853-cob7ur35	130	204	the	the	DT
cord-287853-cob7ur35	130	205	combined	combine	VBN
cord-287853-cob7ur35	130	206	use	use	NN
cord-287853-cob7ur35	130	207	of	of	IN
cord-287853-cob7ur35	130	208	size	size	NN
cord-287853-cob7ur35	130	209	-	-	HYPH
cord-287853-cob7ur35	130	210	exclusion	exclusion	NN
cord-287853-cob7ur35	130	211	chromatography	chromatography	NN
cord-287853-cob7ur35	130	212	,	,	,
cord-287853-cob7ur35	130	213	gel	gel	NN
cord-287853-cob7ur35	130	214	electrophoresis	electrophoresis	NN
cord-287853-cob7ur35	130	215	and	and	CC
cord-287853-cob7ur35	130	216	mass	mass	NN
cord-287853-cob7ur35	130	217	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	218	Strain	strain	NN
cord-287853-cob7ur35	130	219	identification	identification	NN
cord-287853-cob7ur35	130	220	of	of	IN
cord-287853-cob7ur35	130	221	commercial	commercial	JJ
cord-287853-cob7ur35	130	222	influenza	influenza	NN
cord-287853-cob7ur35	130	223	vaccines	vaccine	NNS
cord-287853-cob7ur35	130	224	by	by	IN
cord-287853-cob7ur35	130	225	mass	mass	NN
cord-287853-cob7ur35	130	226	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	227	Simultaneous	simultaneous	JJ
cord-287853-cob7ur35	130	228	quantification	quantification	NN
cord-287853-cob7ur35	130	229	of	of	IN
cord-287853-cob7ur35	130	230	the	the	DT
cord-287853-cob7ur35	130	231	viral	viral	JJ
cord-287853-cob7ur35	130	232	antigens	antigen	NNS
cord-287853-cob7ur35	130	233	hemagglutinin	hemagglutinin	NN
cord-287853-cob7ur35	130	234	and	and	CC
cord-287853-cob7ur35	130	235	neuraminidase	neuraminidase	NN
cord-287853-cob7ur35	130	236	in	in	IN
cord-287853-cob7ur35	130	237	influenza	influenza	NN
cord-287853-cob7ur35	130	238	vaccines	vaccine	NNS
cord-287853-cob7ur35	130	239	by	by	IN
cord-287853-cob7ur35	130	240	LC	LC	NNP
cord-287853-cob7ur35	130	241	-	-	HYPH
cord-287853-cob7ur35	130	242	MS	MS	NNP
cord-287853-cob7ur35	130	243	E	E	NNP
cord-287853-cob7ur35	130	244	Fast	Fast	NNP
cord-287853-cob7ur35	130	245	and	and	CC
cord-287853-cob7ur35	130	246	highly	highly	RB
cord-287853-cob7ur35	130	247	selective	selective	JJ
cord-287853-cob7ur35	130	248	determination	determination	NN
cord-287853-cob7ur35	130	249	of	of	IN
cord-287853-cob7ur35	130	250	hemagglutinin	hemagglutinin	NN
cord-287853-cob7ur35	130	251	content	content	NN
cord-287853-cob7ur35	130	252	in	in	IN
cord-287853-cob7ur35	130	253	quadrivalent	quadrivalent	NNP
cord-287853-cob7ur35	130	254	influenza	influenza	NN
cord-287853-cob7ur35	130	255	vaccine	vaccine	NN
cord-287853-cob7ur35	130	256	by	by	IN
cord-287853-cob7ur35	130	257	reversed	reverse	VBN
cord-287853-cob7ur35	130	258	-	-	HYPH
cord-287853-cob7ur35	130	259	phase	phase	NN
cord-287853-cob7ur35	130	260	high	high	JJ
cord-287853-cob7ur35	130	261	-	-	HYPH
cord-287853-cob7ur35	130	262	performance	performance	NN
cord-287853-cob7ur35	130	263	liquid	liquid	NN
cord-287853-cob7ur35	130	264	chromatography	chromatography	NN
cord-287853-cob7ur35	130	265	method	method	NN
cord-287853-cob7ur35	130	266	Advancing	advance	VBG
cord-287853-cob7ur35	130	267	dengue	dengue	NN
cord-287853-cob7ur35	130	268	vaccine	vaccine	NN
cord-287853-cob7ur35	130	269	development	development	NN
cord-287853-cob7ur35	130	270	Site	site	NN
cord-287853-cob7ur35	130	271	-	-	HYPH
cord-287853-cob7ur35	130	272	specific	specific	JJ
cord-287853-cob7ur35	130	273	characterization	characterization	NN
cord-287853-cob7ur35	130	274	of	of	IN
cord-287853-cob7ur35	130	275	envelope	envelope	NN
cord-287853-cob7ur35	130	276	protein	protein	NN
cord-287853-cob7ur35	130	277	N	n	NN
cord-287853-cob7ur35	130	278	-	-	HYPH
cord-287853-cob7ur35	130	279	glycosylation	glycosylation	NN
cord-287853-cob7ur35	130	280	on	on	IN
cord-287853-cob7ur35	130	281	Sanofi	Sanofi	NNP
cord-287853-cob7ur35	130	282	Pasteur	Pasteur	NNP
cord-287853-cob7ur35	130	283	's	's	POS
cord-287853-cob7ur35	130	284	tetravalent	tetravalent	NN
cord-287853-cob7ur35	130	285	CYD	cyd	NN
cord-287853-cob7ur35	130	286	dengue	dengue	NN
cord-287853-cob7ur35	130	287	vaccine	vaccine	NN
cord-287853-cob7ur35	130	288	Absolute	absolute	JJ
cord-287853-cob7ur35	130	289	quantification	quantification	NN
cord-287853-cob7ur35	130	290	of	of	IN
cord-287853-cob7ur35	130	291	dengue	dengue	NN
cord-287853-cob7ur35	130	292	virus	virus	NN
cord-287853-cob7ur35	130	293	serotype	serotype	NN
cord-287853-cob7ur35	130	294	4	4	CD
cord-287853-cob7ur35	130	295	chimera	chimera	NN
cord-287853-cob7ur35	130	296	vaccine	vaccine	NN
cord-287853-cob7ur35	130	297	candidate	candidate	NN
cord-287853-cob7ur35	130	298	in	in	IN
cord-287853-cob7ur35	130	299	Vero	Vero	NNP
cord-287853-cob7ur35	130	300	cell	cell	NN
cord-287853-cob7ur35	130	301	culture	culture	NN
cord-287853-cob7ur35	130	302	by	by	IN
cord-287853-cob7ur35	130	303	targeted	target	VBN
cord-287853-cob7ur35	130	304	mass	mass	NN
cord-287853-cob7ur35	130	305	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	306	After	after	IN
cord-287853-cob7ur35	130	307	Ebola	Ebola	NNP
cord-287853-cob7ur35	130	308	in	in	IN
cord-287853-cob7ur35	130	309	West	West	NNP
cord-287853-cob7ur35	130	310	Africaunpredictable	Africaunpredictable	NNP
cord-287853-cob7ur35	130	311	risks	risk	NNS
cord-287853-cob7ur35	130	312	,	,	,
cord-287853-cob7ur35	130	313	preventable	preventable	JJ
cord-287853-cob7ur35	130	314	epidemics	epidemic	NNS
cord-287853-cob7ur35	130	315	Identification	Identification	NNP
cord-287853-cob7ur35	130	316	of	of	IN
cord-287853-cob7ur35	130	317	N	n	NN
cord-287853-cob7ur35	130	318	-	-	HYPH
cord-287853-cob7ur35	130	319	glycans	glycan	NNS
cord-287853-cob7ur35	130	320	from	from	IN
cord-287853-cob7ur35	130	321	Ebola	Ebola	NNP
cord-287853-cob7ur35	130	322	virus	virus	NN
cord-287853-cob7ur35	130	323	glycoproteins	glycoprotein	NNS
cord-287853-cob7ur35	130	324	by	by	IN
cord-287853-cob7ur35	130	325	matrix	matrix	NN
cord-287853-cob7ur35	130	326	-	-	HYPH
cord-287853-cob7ur35	130	327	assisted	assist	VBN
cord-287853-cob7ur35	130	328	laser	laser	NN
cord-287853-cob7ur35	130	329	desorption/	desorption/	CD
cord-287853-cob7ur35	130	330	ionisation	ionisation	NN
cord-287853-cob7ur35	130	331	time	time	NN
cord-287853-cob7ur35	130	332	-	-	HYPH
cord-287853-cob7ur35	130	333	of	of	IN
cord-287853-cob7ur35	130	334	-	-	HYPH
cord-287853-cob7ur35	130	335	flight	flight	NN
cord-287853-cob7ur35	130	336	and	and	CC
cord-287853-cob7ur35	130	337	negative	negative	JJ
cord-287853-cob7ur35	130	338	ion	ion	NN
cord-287853-cob7ur35	130	339	electrospray	electrospray	JJ
cord-287853-cob7ur35	130	340	tandem	tandem	JJ
cord-287853-cob7ur35	130	341	mass	mass	NN
cord-287853-cob7ur35	130	342	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	343	Comparison	Comparison	NNP
cord-287853-cob7ur35	130	344	of	of	IN
cord-287853-cob7ur35	130	345	N	N	NNP
cord-287853-cob7ur35	130	346	-	-	:
cord-287853-cob7ur35	130	347	and	and	CC
cord-287853-cob7ur35	130	348	O	o	NN
cord-287853-cob7ur35	130	349	-	-	HYPH
cord-287853-cob7ur35	130	350	linked	link	VBN
cord-287853-cob7ur35	130	351	glycosylation	glycosylation	NN
cord-287853-cob7ur35	130	352	patterns	pattern	NNS
cord-287853-cob7ur35	130	353	of	of	IN
cord-287853-cob7ur35	130	354	ebolavirus	ebolavirus	NN
cord-287853-cob7ur35	130	355	glycoproteins	glycoprotein	NNS
cord-287853-cob7ur35	130	356	Development	Development	NNP
cord-287853-cob7ur35	130	357	of	of	IN
cord-287853-cob7ur35	130	358	a	a	DT
cord-287853-cob7ur35	130	359	liquid	liquid	JJ
cord-287853-cob7ur35	130	360	chromatography	chromatography	NN
cord-287853-cob7ur35	130	361	high	high	JJ
cord-287853-cob7ur35	130	362	resolution	resolution	NN
cord-287853-cob7ur35	130	363	mass	mass	NN
cord-287853-cob7ur35	130	364	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	365	method	method	NN
cord-287853-cob7ur35	130	366	for	for	IN
cord-287853-cob7ur35	130	367	the	the	DT
cord-287853-cob7ur35	130	368	quantitation	quantitation	NN
cord-287853-cob7ur35	130	369	of	of	IN
cord-287853-cob7ur35	130	370	viral	viral	JJ
cord-287853-cob7ur35	130	371	envelope	envelope	NN
cord-287853-cob7ur35	130	372	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	130	373	in	in	IN
cord-287853-cob7ur35	130	374	Ebola	Ebola	NNP
cord-287853-cob7ur35	130	375	virus	virus	NN
cord-287853-cob7ur35	130	376	-	-	HYPH
cord-287853-cob7ur35	130	377	like	like	JJ
cord-287853-cob7ur35	130	378	particle	particle	NN
cord-287853-cob7ur35	130	379	vaccine	vaccine	NN
cord-287853-cob7ur35	130	380	preparations	preparation	NNS
cord-287853-cob7ur35	130	381	Chikungunya	Chikungunya	NNP
cord-287853-cob7ur35	130	382	virus	virus	NN
cord-287853-cob7ur35	130	383	:	:	:
cord-287853-cob7ur35	130	384	pathophysiology	pathophysiology	NN
cord-287853-cob7ur35	130	385	,	,	,
cord-287853-cob7ur35	130	386	mechanism	mechanism	NN
cord-287853-cob7ur35	130	387	,	,	,
cord-287853-cob7ur35	130	388	and	and	CC
cord-287853-cob7ur35	130	389	modeling	model	VBG
cord-287853-cob7ur35	130	390	Development	development	NN
cord-287853-cob7ur35	130	391	and	and	CC
cord-287853-cob7ur35	130	392	application	application	NN
cord-287853-cob7ur35	130	393	of	of	IN
cord-287853-cob7ur35	130	394	a	a	DT
cord-287853-cob7ur35	130	395	reversed	reverse	VBN
cord-287853-cob7ur35	130	396	-	-	HYPH
cord-287853-cob7ur35	130	397	phase	phase	NN
cord-287853-cob7ur35	130	398	high	high	JJ
cord-287853-cob7ur35	130	399	-	-	HYPH
cord-287853-cob7ur35	130	400	performance	performance	NN
cord-287853-cob7ur35	130	401	liquid	liquid	NN
cord-287853-cob7ur35	130	402	chromatographic	chromatographic	JJ
cord-287853-cob7ur35	130	403	method	method	NN
cord-287853-cob7ur35	130	404	for	for	IN
cord-287853-cob7ur35	130	405	quantitation	quantitation	NN
cord-287853-cob7ur35	130	406	and	and	CC
cord-287853-cob7ur35	130	407	characterization	characterization	NN
cord-287853-cob7ur35	130	408	of	of	IN
cord-287853-cob7ur35	130	409	a	a	DT
cord-287853-cob7ur35	130	410	Chikungunya	Chikungunya	NNP
cord-287853-cob7ur35	130	411	virus	virus	NN
cord-287853-cob7ur35	130	412	-	-	:
cord-287853-cob7ur35	130	413	like	like	JJ
cord-287853-cob7ur35	130	414	particle	particle	NN
cord-287853-cob7ur35	130	415	vaccine	vaccine	NN
cord-287853-cob7ur35	130	416	Characterization	characterization	NN
cord-287853-cob7ur35	130	417	of	of	IN
cord-287853-cob7ur35	130	418	Nglycosylation	Nglycosylation	NNP
cord-287853-cob7ur35	130	419	profiles	profile	NNS
cord-287853-cob7ur35	130	420	from	from	IN
cord-287853-cob7ur35	130	421	mammalian	mammalian	JJ
cord-287853-cob7ur35	130	422	and	and	CC
cord-287853-cob7ur35	130	423	insect	insect	NN
cord-287853-cob7ur35	130	424	cell	cell	NN
cord-287853-cob7ur35	130	425	derived	derive	VBD
cord-287853-cob7ur35	130	426	chikungunya	chikungunya	NN
cord-287853-cob7ur35	130	427	VLP	VLP	NNP
cord-287853-cob7ur35	130	428	Label	Label	NNP
cord-287853-cob7ur35	130	429	-	-	HYPH
cord-287853-cob7ur35	130	430	free	free	JJ
cord-287853-cob7ur35	130	431	quantitative	quantitative	JJ
cord-287853-cob7ur35	130	432	mass	mass	NN
cord-287853-cob7ur35	130	433	spectrometry	spectrometry	NN
cord-287853-cob7ur35	130	434	for	for	IN
cord-287853-cob7ur35	130	435	analysis	analysis	NN
cord-287853-cob7ur35	130	436	of	of	IN
cord-287853-cob7ur35	130	437	protein	protein	NN
cord-287853-cob7ur35	130	438	antigens	antigen	NNS
cord-287853-cob7ur35	130	439	in	in	IN
cord-287853-cob7ur35	130	440	a	a	DT
cord-287853-cob7ur35	130	441	meningococcal	meningococcal	JJ
cord-287853-cob7ur35	130	442	group	group	NN
cord-287853-cob7ur35	130	443	B	b	NN
cord-287853-cob7ur35	130	444	outer	outer	JJ
cord-287853-cob7ur35	130	445	membrane	membrane	NN
cord-287853-cob7ur35	130	446	vesicle	vesicle	NN
cord-287853-cob7ur35	130	447	vaccine	vaccine	NN
cord-287853-cob7ur35	130	448	Physicochemical	Physicochemical	NNP
cord-287853-cob7ur35	130	449	characterisation	characterisation	NN
cord-287853-cob7ur35	130	450	of	of	IN
cord-287853-cob7ur35	130	451	glycoconjugate	glycoconjugate	JJ
cord-287853-cob7ur35	130	452	vaccines	vaccine	NNS
cord-287853-cob7ur35	130	453	for	for	IN
cord-287853-cob7ur35	130	454	prevention	prevention	NN
cord-287853-cob7ur35	130	455	of	of	IN
cord-287853-cob7ur35	130	456	meningococcal	meningococcal	JJ
cord-287853-cob7ur35	130	457	diseases	disease	NNS
cord-287853-cob7ur35	131	1	Defined	define	VBN
cord-287853-cob7ur35	131	2	conjugation	conjugation	NN
cord-287853-cob7ur35	131	3	of	of	IN
cord-287853-cob7ur35	131	4	glycans	glycan	NNS
cord-287853-cob7ur35	131	5	to	to	IN
cord-287853-cob7ur35	131	6	the	the	DT
cord-287853-cob7ur35	131	7	lysines	lysine	NNS
cord-287853-cob7ur35	131	8	of	of	IN
cord-287853-cob7ur35	131	9	CRM	CRM	NNP
cord-287853-cob7ur35	131	10	197	197	CD
cord-287853-cob7ur35	131	11	guided	guide	VBN
cord-287853-cob7ur35	131	12	by	by	IN
cord-287853-cob7ur35	131	13	their	-PRON-	PRP$
cord-287853-cob7ur35	131	14	reactivity	reactivity	NN
cord-287853-cob7ur35	131	15	mapping	mapping	NN
cord-287853-cob7ur35	131	16	Quantification	quantification	NN
cord-287853-cob7ur35	131	17	by	by	IN
cord-287853-cob7ur35	131	18	LC	LC	NNP
cord-287853-cob7ur35	131	19	-	-	HYPH
cord-287853-cob7ur35	131	20	MS	MS	NNP
cord-287853-cob7ur35	131	21	E	E	NNP
cord-287853-cob7ur35	131	22	of	of	IN
cord-287853-cob7ur35	131	23	outer	outer	JJ
cord-287853-cob7ur35	131	24	membrane	membrane	NN
cord-287853-cob7ur35	131	25	vesicle	vesicle	NN
cord-287853-cob7ur35	131	26	proteins	protein	NNS
cord-287853-cob7ur35	131	27	of	of	IN
cord-287853-cob7ur35	131	28	the	the	DT
cord-287853-cob7ur35	131	29	Bexsero	Bexsero	NNP
cord-287853-cob7ur35	131	30	®	®	POS
cord-287853-cob7ur35	131	31	vaccine	vaccine	NN
cord-287853-cob7ur35	132	1	The	the	DT
cord-287853-cob7ur35	132	2	dual	dual	JJ
cord-287853-cob7ur35	132	3	role	role	NN
cord-287853-cob7ur35	132	4	of	of	IN
cord-287853-cob7ur35	132	5	lipids	lipid	NNS
cord-287853-cob7ur35	132	6	of	of	IN
cord-287853-cob7ur35	132	7	the	the	DT
cord-287853-cob7ur35	132	8	lipoproteins	lipoprotein	NNS
cord-287853-cob7ur35	132	9	in	in	IN
cord-287853-cob7ur35	132	10	Trumenba	Trumenba	NNP
cord-287853-cob7ur35	132	11	,	,	,
cord-287853-cob7ur35	132	12	a	a	DT
cord-287853-cob7ur35	132	13	self	self	NN
cord-287853-cob7ur35	132	14	-	-	HYPH
cord-287853-cob7ur35	132	15	adjuvanting	adjuvante	VBG
cord-287853-cob7ur35	132	16	vaccine	vaccine	NN
cord-287853-cob7ur35	132	17	against	against	IN
cord-287853-cob7ur35	132	18	meningococcal	meningococcal	JJ
cord-287853-cob7ur35	132	19	meningitis	meningitis	NN
cord-287853-cob7ur35	132	20	B	B	NNP
cord-287853-cob7ur35	132	21	disease	disease	NN
cord-287853-cob7ur35	132	22	Robust	robust	JJ
cord-287853-cob7ur35	132	23	manufacturing	manufacturing	NN
cord-287853-cob7ur35	132	24	and	and	CC
cord-287853-cob7ur35	132	25	comprehensive	comprehensive	JJ
cord-287853-cob7ur35	132	26	characterization	characterization	NN
cord-287853-cob7ur35	132	27	of	of	IN
cord-287853-cob7ur35	132	28	recombinant	recombinant	JJ
cord-287853-cob7ur35	132	29	hepatitis	hepatitis	NN
cord-287853-cob7ur35	132	30	E	e	NN
cord-287853-cob7ur35	132	31	viruslike	viruslike	JJ
cord-287853-cob7ur35	132	32	particles	particle	NNS
cord-287853-cob7ur35	132	33	in	in	IN
cord-287853-cob7ur35	132	34	Hecolin	Hecolin	NNP
cord-287853-cob7ur35	133	1	®	®	.
cord-287853-cob7ur35	134	1	Hepatitis	hepatitis	NN
cord-287853-cob7ur35	134	2	E	e	NN
cord-287853-cob7ur35	134	3	virus	virus	NN
cord-287853-cob7ur35	134	4	:	:	:
cord-287853-cob7ur35	134	5	a	a	DT
cord-287853-cob7ur35	134	6	renewed	renew	VBN
cord-287853-cob7ur35	134	7	hope	hope	NN
cord-287853-cob7ur35	134	8	with	with	IN
cord-287853-cob7ur35	134	9	Hecolin	Hecolin	NNP
cord-287853-cob7ur35	134	10	Molecular	Molecular	NNP
cord-287853-cob7ur35	134	11	and	and	CC
cord-287853-cob7ur35	134	12	structural	structural	JJ
cord-287853-cob7ur35	134	13	characterization	characterization	NN
cord-287853-cob7ur35	134	14	of	of	IN
cord-287853-cob7ur35	134	15	the	the	DT
cord-287853-cob7ur35	134	16	L1	L1	NNP
cord-287853-cob7ur35	134	17	virus	virus	NN
cord-287853-cob7ur35	134	18	-	-	HYPH
cord-287853-cob7ur35	134	19	like	like	JJ
cord-287853-cob7ur35	134	20	particles	particle	NNS
cord-287853-cob7ur35	134	21	that	that	WDT
cord-287853-cob7ur35	134	22	are	be	VBP
cord-287853-cob7ur35	134	23	used	use	VBN
cord-287853-cob7ur35	134	24	as	as	IN
cord-287853-cob7ur35	134	25	vaccine	vaccine	NN
cord-287853-cob7ur35	134	26	antigens	antigen	NNS
cord-287853-cob7ur35	134	27	in	in	IN
cord-287853-cob7ur35	134	28	Cervarix	Cervarix	NNP
cord-287853-cob7ur35	134	29	™	™	CD
cord-287853-cob7ur35	134	30	,	,	,
cord-287853-cob7ur35	134	31	the	the	DT
cord-287853-cob7ur35	134	32	AS04-adjuvanted	AS04-adjuvanted	NNP
cord-287853-cob7ur35	134	33	HPV-16	HPV-16	NNP
cord-287853-cob7ur35	134	34	and-18	and-18	NN
cord-287853-cob7ur35	134	35	cervical	cervical	JJ
cord-287853-cob7ur35	134	36	cancer	cancer	NN
cord-287853-cob7ur35	134	37	vaccine	vaccine	NN
cord-287853-cob7ur35	134	38	Viruslike	Viruslike	NNP
cord-287853-cob7ur35	134	39	particles	particle	NNS
cord-287853-cob7ur35	134	40	in	in	IN
cord-287853-cob7ur35	134	41	vaccine	vaccine	NN
cord-287853-cob7ur35	134	42	development	development	NN
cord-287853-cob7ur35	134	43	Virus	Virus	NNP
cord-287853-cob7ur35	134	44	-	-	HYPH
cord-287853-cob7ur35	134	45	like	like	JJ
cord-287853-cob7ur35	134	46	particle	particle	NN
cord-287853-cob7ur35	134	47	-	-	HYPH
cord-287853-cob7ur35	134	48	based	base	VBN
cord-287853-cob7ur35	134	49	human	human	JJ
cord-287853-cob7ur35	134	50	vaccines	vaccine	NNS
cord-287853-cob7ur35	134	51	:	:	:
cord-287853-cob7ur35	134	52	quality	quality	NN
cord-287853-cob7ur35	134	53	assessment	assessment	NN
cord-287853-cob7ur35	134	54	based	base	VBN
cord-287853-cob7ur35	134	55	on	on	IN
cord-287853-cob7ur35	134	56	structural	structural	JJ
cord-287853-cob7ur35	134	57	and	and	CC
cord-287853-cob7ur35	134	58	functional	functional	JJ
cord-287853-cob7ur35	134	59	properties	property	NNS
cord-287853-cob7ur35	134	60	Status	status	NN
cord-287853-cob7ur35	134	61	of	of	IN
cord-287853-cob7ur35	134	62	vaccine	vaccine	NN
cord-287853-cob7ur35	134	63	research	research	NN
cord-287853-cob7ur35	134	64	and	and	CC
cord-287853-cob7ur35	134	65	development	development	NN
cord-287853-cob7ur35	134	66	of	of	IN
cord-287853-cob7ur35	134	67	vaccines	vaccine	NNS
cord-287853-cob7ur35	134	68	for	for	IN
cord-287853-cob7ur35	134	69	Nipah	Nipah	NNP
cord-287853-cob7ur35	134	70	virus	virus	NN
cord-287853-cob7ur35	134	71	Proteomic	Proteomic	NNP
cord-287853-cob7ur35	134	72	composition	composition	NN
cord-287853-cob7ur35	134	73	of	of	IN
cord-287853-cob7ur35	134	74	Nipah	Nipah	NNP
cord-287853-cob7ur35	134	75	virus	virus	NN
cord-287853-cob7ur35	134	76	-	-	HYPH
cord-287853-cob7ur35	134	77	like	like	JJ
cord-287853-cob7ur35	134	78	particles	particle	NNS
cord-287853-cob7ur35	134	79	Production	production	NN
cord-287853-cob7ur35	134	80	of	of	IN
cord-287853-cob7ur35	134	81	immunogenic	immunogenic	JJ
cord-287853-cob7ur35	134	82	West	West	NNP
cord-287853-cob7ur35	134	83	Nile	Nile	NNP
cord-287853-cob7ur35	134	84	virus	virus	NN
cord-287853-cob7ur35	134	85	-	-	HYPH
cord-287853-cob7ur35	134	86	like	like	JJ
cord-287853-cob7ur35	134	87	particles	particle	NNS
cord-287853-cob7ur35	134	88	using	use	VBG
cord-287853-cob7ur35	134	89	a	a	DT
cord-287853-cob7ur35	134	90	herpes	herpes	NN
cord-287853-cob7ur35	134	91	simplex	simplex	NN
cord-287853-cob7ur35	134	92	virus	virus	NN
cord-287853-cob7ur35	134	93	1	1	CD
cord-287853-cob7ur35	134	94	recombinant	recombinant	NN
cord-287853-cob7ur35	134	95	vector	vector	NN
cord-287853-cob7ur35	134	96	Characterization	characterization	NN
cord-287853-cob7ur35	134	97	of	of	IN
cord-287853-cob7ur35	134	98	human	human	JJ
cord-287853-cob7ur35	134	99	enterovirus71	enterovirus71	NNS
cord-287853-cob7ur35	134	100	virus	virus	NN
cord-287853-cob7ur35	134	101	-	-	HYPH
cord-287853-cob7ur35	134	102	like	like	JJ
cord-287853-cob7ur35	134	103	particles	particle	NNS
cord-287853-cob7ur35	134	104	used	use	VBN
cord-287853-cob7ur35	134	105	for	for	IN
cord-287853-cob7ur35	134	106	vaccine	vaccine	NN
cord-287853-cob7ur35	134	107	antigens	antigen	NNS
cord-287853-cob7ur35	134	108	Mass	Mass	NNP
cord-287853-cob7ur35	134	109	spectrometric	spectrometric	JJ
cord-287853-cob7ur35	134	110	characterization	characterization	NN
cord-287853-cob7ur35	134	111	of	of	IN
cord-287853-cob7ur35	134	112	the	the	DT
cord-287853-cob7ur35	134	113	glycosylation	glycosylation	NN
cord-287853-cob7ur35	134	114	pattern	pattern	NN
cord-287853-cob7ur35	134	115	of	of	IN
cord-287853-cob7ur35	134	116	HIV	HIV	NNP
cord-287853-cob7ur35	134	117	-	-	HYPH
cord-287853-cob7ur35	134	118	gp120	gp120	NNP
cord-287853-cob7ur35	134	119	expressed	express	VBN
cord-287853-cob7ur35	134	120	in	in	IN
cord-287853-cob7ur35	134	121	CHO	CHO	NNP
cord-287853-cob7ur35	134	122	cells	cell	NNS
cord-287853-cob7ur35	135	1	Glycan	glycan	JJ
cord-287853-cob7ur35	135	2	profiles	profile	NNS
cord-287853-cob7ur35	135	3	of	of	IN
cord-287853-cob7ur35	135	4	the	the	DT
cord-287853-cob7ur35	135	5	27	27	CD
cord-287853-cob7ur35	135	6	N	n	CD
cord-287853-cob7ur35	135	7	-	-	HYPH
cord-287853-cob7ur35	135	8	glycosylation	glycosylation	NN
cord-287853-cob7ur35	135	9	sites	site	NNS
cord-287853-cob7ur35	135	10	of	of	IN
cord-287853-cob7ur35	135	11	the	the	DT
cord-287853-cob7ur35	135	12	HIV	HIV	NNP
cord-287853-cob7ur35	135	13	envelope	envelope	NN
cord-287853-cob7ur35	135	14	protein	protein	NN
cord-287853-cob7ur35	135	15	CN54gp140	CN54gp140	NNP
cord-287853-cob7ur35	135	16	Comparative	Comparative	NNP
cord-287853-cob7ur35	135	17	analysis	analysis	NN
cord-287853-cob7ur35	135	18	of	of	IN
cord-287853-cob7ur35	135	19	the	the	DT
cord-287853-cob7ur35	135	20	glycosylation	glycosylation	NN
cord-287853-cob7ur35	135	21	profiles	profile	NNS
cord-287853-cob7ur35	135	22	of	of	IN
cord-287853-cob7ur35	135	23	membrane	membrane	NN
cord-287853-cob7ur35	135	24	-	-	HYPH
cord-287853-cob7ur35	135	25	anchored	anchor	VBN
cord-287853-cob7ur35	135	26	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	135	27	envelope	envelope	NN
cord-287853-cob7ur35	135	28	glycoprotein	glycoprotein	NN
cord-287853-cob7ur35	135	29	trimers	trimer	NNS
cord-287853-cob7ur35	135	30	and	and	CC
cord-287853-cob7ur35	135	31	soluble	soluble	JJ
cord-287853-cob7ur35	135	32	gp140	gp140	CD
cord-287853-cob7ur35	136	1	Mapping	map	VBG
cord-287853-cob7ur35	136	2	the	the	DT
cord-287853-cob7ur35	136	3	complete	complete	JJ
cord-287853-cob7ur35	136	4	glycoproteome	glycoproteome	NN
cord-287853-cob7ur35	136	5	of	of	IN
cord-287853-cob7ur35	136	6	virion	virion	NN
cord-287853-cob7ur35	136	7	-	-	HYPH
cord-287853-cob7ur35	136	8	derived	derive	VBN
cord-287853-cob7ur35	136	9	HIV-1	HIV-1	NNP
cord-287853-cob7ur35	136	10	gp120	gp120	NNP
cord-287853-cob7ur35	136	11	provides	provide	VBZ
cord-287853-cob7ur35	136	12	insights	insight	NNS
cord-287853-cob7ur35	136	13	into	into	IN
cord-287853-cob7ur35	136	14	broadly	broadly	RB
cord-287853-cob7ur35	136	15	neutralizing	neutralize	VBG
cord-287853-cob7ur35	136	16	antibody	antibody	NN
cord-287853-cob7ur35	136	17	binding	bind	VBG
cord-287853-cob7ur35	136	18	Haemagglutinin	Haemagglutinin	NNP
cord-287853-cob7ur35	136	19	quantification	quantification	NN
cord-287853-cob7ur35	136	20	and	and	CC
cord-287853-cob7ur35	136	21	identification	identification	NN
cord-287853-cob7ur35	136	22	of	of	IN
cord-287853-cob7ur35	136	23	influenza	influenza	NN
cord-287853-cob7ur35	136	24	A&B	A&B	NNP
cord-287853-cob7ur35	136	25	strains	strain	NNS
cord-287853-cob7ur35	136	26	propagated	propagate	VBN
cord-287853-cob7ur35	136	27	in	in	IN
cord-287853-cob7ur35	136	28	PER	per	NN
cord-287853-cob7ur35	136	29	.	.	.
cord-287853-cob7ur35	137	1	C6	C6	NNP
cord-287853-cob7ur35	138	1	®	®	NNP
cord-287853-cob7ur35	138	2	cells	cell	NNS
cord-287853-cob7ur35	138	3	:	:	:
cord-287853-cob7ur35	138	4	a	a	DT
cord-287853-cob7ur35	138	5	novel	novel	JJ
cord-287853-cob7ur35	138	6	RP	rp	NN
cord-287853-cob7ur35	138	7	-	-	HYPH
cord-287853-cob7ur35	138	8	HPLC	HPLC	NNP
cord-287853-cob7ur35	138	9	method	method	NN
cord-287853-cob7ur35	138	10	HPLC	HPLC	NNP
cord-287853-cob7ur35	138	11	-	-	HYPH
cord-287853-cob7ur35	138	12	based	base	VBN
cord-287853-cob7ur35	138	13	quantification	quantification	NN
cord-287853-cob7ur35	138	14	of	of	IN
cord-287853-cob7ur35	138	15	haemagglutinin	haemagglutinin	NNP
cord-287853-cob7ur35	138	16	in	in	IN
cord-287853-cob7ur35	138	17	the	the	DT
cord-287853-cob7ur35	138	18	production	production	NN
cord-287853-cob7ur35	138	19	of	of	IN
cord-287853-cob7ur35	138	20	egg	egg	NN
cord-287853-cob7ur35	138	21	-	-	:
cord-287853-cob7ur35	138	22	and	and	CC
cord-287853-cob7ur35	138	23	MDCK	MDCK	NNP
cord-287853-cob7ur35	138	24	cell	cell	NN
cord-287853-cob7ur35	138	25	-	-	HYPH
cord-287853-cob7ur35	138	26	derived	derive	VBN
cord-287853-cob7ur35	138	27	influenza	influenza	NN
cord-287853-cob7ur35	138	28	virus	virus	NN
cord-287853-cob7ur35	138	29	seasonal	seasonal	JJ
cord-287853-cob7ur35	138	30	and	and	CC
cord-287853-cob7ur35	138	31	pandemic	pandemic	JJ
cord-287853-cob7ur35	138	32	vaccines	vaccine	NNS
cord-287853-cob7ur35	138	33	Optimization	optimization	NN
cord-287853-cob7ur35	138	34	and	and	CC
cord-287853-cob7ur35	138	35	qualification	qualification	NN
cord-287853-cob7ur35	138	36	of	of	IN
cord-287853-cob7ur35	138	37	a	a	DT
cord-287853-cob7ur35	138	38	quantitative	quantitative	JJ
cord-287853-cob7ur35	138	39	reversed	reverse	VBN
cord-287853-cob7ur35	138	40	-	-	HYPH
cord-287853-cob7ur35	138	41	phase	phase	NN
cord-287853-cob7ur35	138	42	HPLC	HPLC	NNP
cord-287853-cob7ur35	138	43	method	method	NN
cord-287853-cob7ur35	138	44	for	for	IN
cord-287853-cob7ur35	138	45	hemagglutinin	hemagglutinin	NN
cord-287853-cob7ur35	138	46	in	in	IN
cord-287853-cob7ur35	138	47	influenza	influenza	NN
cord-287853-cob7ur35	138	48	preparations	preparation	NNS
cord-287853-cob7ur35	138	49	and	and	CC
cord-287853-cob7ur35	138	50	its	-PRON-	PRP$
cord-287853-cob7ur35	138	51	comparative	comparative	JJ
cord-287853-cob7ur35	138	52	evaluation	evaluation	NN
cord-287853-cob7ur35	138	53	with	with	IN
cord-287853-cob7ur35	138	54	biochemical	biochemical	JJ
cord-287853-cob7ur35	138	55	assays	assay	NNS
cord-287853-cob7ur35	138	56	Characterization	characterization	NN
cord-287853-cob7ur35	138	57	of	of	IN
cord-287853-cob7ur35	138	58	a	a	DT
cord-287853-cob7ur35	138	59	recombinant	recombinant	JJ
cord-287853-cob7ur35	138	60	influenza	influenza	NN
cord-287853-cob7ur35	138	61	vaccine	vaccine	NN
cord-287853-cob7ur35	138	62	candidate	candidate	NN
cord-287853-cob7ur35	138	63	using	use	VBG
cord-287853-cob7ur35	138	64	complementary	complementary	JJ
cord-287853-cob7ur35	138	65	LC	LC	NNP
cord-287853-cob7ur35	138	66	-	-	HYPH
cord-287853-cob7ur35	138	67	MS	MS	NNP
cord-287853-cob7ur35	138	68	methods	method	NNS
cord-287853-cob7ur35	138	69	Comparative	Comparative	NNP
cord-287853-cob7ur35	138	70	glycomics	glycomic	NNS
cord-287853-cob7ur35	138	71	analysis	analysis	NN
cord-287853-cob7ur35	138	72	of	of	IN
cord-287853-cob7ur35	138	73	influenza	influenza	NN
cord-287853-cob7ur35	138	74	hemagglutinin	hemagglutinin	NNP
cord-287853-cob7ur35	138	75	(	(	-LRB-
cord-287853-cob7ur35	138	76	H5N1	H5N1	NNP
cord-287853-cob7ur35	138	77	)	)	-RRB-
cord-287853-cob7ur35	138	78	produced	produce	VBN
cord-287853-cob7ur35	138	79	in	in	IN
cord-287853-cob7ur35	138	80	vaccine	vaccine	NN
cord-287853-cob7ur35	138	81	relevant	relevant	JJ
cord-287853-cob7ur35	138	82	cell	cell	NN
cord-287853-cob7ur35	138	83	platforms	platform	NNS
cord-287853-cob7ur35	138	84	Glycosylation	Glycosylation	NNP
cord-287853-cob7ur35	138	85	analysis	analysis	NN
cord-287853-cob7ur35	138	86	of	of	IN
cord-287853-cob7ur35	138	87	engineered	engineer	VBN
cord-287853-cob7ur35	138	88	H3N2	H3N2	NNP
cord-287853-cob7ur35	138	89	influenza	influenza	NN
cord-287853-cob7ur35	138	90	A	a	DT
cord-287853-cob7ur35	138	91	virus	virus	NN
cord-287853-cob7ur35	138	92	hemagglutinins	hemagglutinin	VBZ
cord-287853-cob7ur35	138	93	with	with	IN
cord-287853-cob7ur35	138	94	sequentially	sequentially	RB
cord-287853-cob7ur35	138	95	added	add	VBN
cord-287853-cob7ur35	138	96	historically	historically	RB
cord-287853-cob7ur35	138	97	relevant	relevant	JJ
cord-287853-cob7ur35	138	98	glycosylation	glycosylation	NN
cord-287853-cob7ur35	138	99	sites	site	NNS
cord-287853-cob7ur35	138	100	Particle	particle	NN
cord-287853-cob7ur35	138	101	quantification	quantification	NN
cord-287853-cob7ur35	138	102	of	of	IN
cord-287853-cob7ur35	138	103	influenza	influenza	NN
cord-287853-cob7ur35	138	104	viruses	virus	NNS
cord-287853-cob7ur35	138	105	by	by	IN
cord-287853-cob7ur35	138	106	high	high	JJ
cord-287853-cob7ur35	138	107	performance	performance	NN
cord-287853-cob7ur35	138	108	liquid	liquid	NN
cord-287853-cob7ur35	138	109	chromatography	chromatography	NN
cord-287853-cob7ur35	138	110	Design	design	NN
cord-287853-cob7ur35	138	111	and	and	CC
cord-287853-cob7ur35	138	112	expression	expression	NN
cord-287853-cob7ur35	138	113	of	of	IN
cord-287853-cob7ur35	138	114	a	a	DT
cord-287853-cob7ur35	138	115	QconCAT	QconCAT	NNP
cord-287853-cob7ur35	138	116	protein	protein	NN
cord-287853-cob7ur35	138	117	to	to	TO
cord-287853-cob7ur35	138	118	validate	validate	VB
cord-287853-cob7ur35	138	119	Hi3	hi3	CD
cord-287853-cob7ur35	138	120	protein	protein	NN
cord-287853-cob7ur35	138	121	quantification	quantification	NN
cord-287853-cob7ur35	138	122	of	of	IN
cord-287853-cob7ur35	138	123	influenza	influenza	JJ
cord-287853-cob7ur35	138	124	vaccine	vaccine	NN
cord-287853-cob7ur35	138	125	antigens	antigen	NNS
cord-287853-cob7ur35	138	126	Evaluation	Evaluation	NNP
cord-287853-cob7ur35	138	127	of	of	IN
cord-287853-cob7ur35	138	128	haemagglutinin	haemagglutinin	NNP
cord-287853-cob7ur35	138	129	content	content	NN
cord-287853-cob7ur35	138	130	by	by	IN
cord-287853-cob7ur35	138	131	RP	RP	NNP
cord-287853-cob7ur35	138	132	-	-	HYPH
cord-287853-cob7ur35	138	133	HPLC	HPLC	NNP
cord-287853-cob7ur35	138	134	to	to	TO
cord-287853-cob7ur35	138	135	generate	generate	VB
cord-287853-cob7ur35	138	136	pandemic	pandemic	NN
cord-287853-cob7ur35	138	137	influenza	influenza	NN
cord-287853-cob7ur35	138	138	vaccine	vaccine	NN
cord-287853-cob7ur35	138	139	Topological	Topological	NNP
cord-287853-cob7ur35	138	140	N	n	NN
cord-287853-cob7ur35	138	141	-	-	HYPH
cord-287853-cob7ur35	138	142	glycosylation	glycosylation	NN
cord-287853-cob7ur35	138	143	and	and	CC
cord-287853-cob7ur35	138	144	site	site	NN
cord-287853-cob7ur35	138	145	-	-	HYPH
cord-287853-cob7ur35	138	146	specific	specific	JJ
cord-287853-cob7ur35	138	147	N	n	CD
cord-287853-cob7ur35	138	148	-	-	HYPH
cord-287853-cob7ur35	138	149	glycan	glycan	NN
cord-287853-cob7ur35	138	150	sulfation	sulfation	NN
cord-287853-cob7ur35	138	151	of	of	IN
cord-287853-cob7ur35	138	152	influenza	influenza	NN
cord-287853-cob7ur35	138	153	proteins	protein	NNS
cord-287853-cob7ur35	138	154	in	in	IN
cord-287853-cob7ur35	138	155	the	the	DT
cord-287853-cob7ur35	138	156	highly	highly	RB
cord-287853-cob7ur35	138	157	expressed	express	VBN
cord-287853-cob7ur35	138	158	H1N1	H1N1	NNP
cord-287853-cob7ur35	138	159	candidate	candidate	NN
cord-287853-cob7ur35	138	160	vaccines	vaccine	NNS
cord-287853-cob7ur35	138	161	Glycosylation	Glycosylation	NNP
cord-287853-cob7ur35	138	162	characterization	characterization	NN
cord-287853-cob7ur35	138	163	of	of	IN
cord-287853-cob7ur35	138	164	an	an	DT
cord-287853-cob7ur35	138	165	influenza	influenza	NN
cord-287853-cob7ur35	138	166	h5n7	h5n7	VBG
cord-287853-cob7ur35	138	167	hemagglutinin	hemagglutinin	NN
cord-287853-cob7ur35	138	168	series	series	NN
cord-287853-cob7ur35	138	169	with	with	IN
cord-287853-cob7ur35	138	170	engineered	engineer	VBN
cord-287853-cob7ur35	138	171	glycosylation	glycosylation	NN
cord-287853-cob7ur35	138	172	patterns	pattern	NNS
cord-287853-cob7ur35	138	173	:	:	:
cord-287853-cob7ur35	138	174	implications	implication	NNS
cord-287853-cob7ur35	138	175	for	for	IN
cord-287853-cob7ur35	138	176	structurefunction	structurefunction	NN
cord-287853-cob7ur35	138	177	relationships	relationship	NNS
cord-287853-cob7ur35	139	1	Cross	Cross	NNP
cord-287853-cob7ur35	139	2	Reactive	Reactive	NNP
cord-287853-cob7ur35	139	3	Material	Material	NNP
cord-287853-cob7ur35	139	4	197	197	CD
cord-287853-cob7ur35	139	5	glycoconjugate	glycoconjugate	NN
cord-287853-cob7ur35	139	6	vaccines	vaccine	NNS
cord-287853-cob7ur35	139	7	contain	contain	VBP
cord-287853-cob7ur35	139	8	privileged	privileged	JJ
cord-287853-cob7ur35	139	9	conjugation	conjugation	NN
cord-287853-cob7ur35	139	10	sites	site	NNS
cord-287853-cob7ur35	139	11	Quality	quality	NN
cord-287853-cob7ur35	139	12	by	by	IN
cord-287853-cob7ur35	139	13	design	design	NN
cord-287853-cob7ur35	139	14	approach	approach	NN
cord-287853-cob7ur35	139	15	in	in	IN
cord-287853-cob7ur35	139	16	the	the	DT
cord-287853-cob7ur35	139	17	development	development	NN
cord-287853-cob7ur35	139	18	of	of	IN
cord-287853-cob7ur35	139	19	an	an	DT
cord-287853-cob7ur35	139	20	ultra	ultra	JJ
cord-287853-cob7ur35	139	21	-	-	JJ
cord-287853-cob7ur35	139	22	high	high	JJ
cord-287853-cob7ur35	139	23	-	-	HYPH
cord-287853-cob7ur35	139	24	performance	performance	NN
cord-287853-cob7ur35	139	25	liquid	liquid	NN
cord-287853-cob7ur35	139	26	chromatography	chromatography	NN
cord-287853-cob7ur35	139	27	method	method	NN
cord-287853-cob7ur35	139	28	for	for	IN
cord-287853-cob7ur35	139	29	Bexsero	Bexsero	NNP
cord-287853-cob7ur35	139	30	meningococcal	meningococcal	JJ
cord-287853-cob7ur35	139	31	group	group	NN
cord-287853-cob7ur35	139	32	B	B	NNP
cord-287853-cob7ur35	139	33	vaccine	vaccine	NN
cord-287853-cob7ur35	139	34	Proteomics	Proteomics	NNP
cord-287853-cob7ur35	139	35	-	-	HYPH
cord-287853-cob7ur35	139	36	driven	drive	VBN
cord-287853-cob7ur35	139	37	antigen	antigen	NN
cord-287853-cob7ur35	139	38	discovery	discovery	NN
cord-287853-cob7ur35	139	39	for	for	IN
cord-287853-cob7ur35	139	40	development	development	NN
cord-287853-cob7ur35	139	41	of	of	IN
cord-287853-cob7ur35	139	42	vaccines	vaccine	NNS
cord-287853-cob7ur35	139	43	against	against	IN
cord-287853-cob7ur35	139	44	gonorrhea	gonorrhea	NN
cord-287853-cob7ur35	139	45	Production	production	NN
cord-287853-cob7ur35	139	46	and	and	CC
cord-287853-cob7ur35	139	47	purification	purification	NN
cord-287853-cob7ur35	139	48	of	of	IN
cord-287853-cob7ur35	139	49	filovirus	filovirus	NN
cord-287853-cob7ur35	139	50	glycoproteins	glycoprotein	NNS
cord-287853-cob7ur35	139	51	in	in	IN
cord-287853-cob7ur35	139	52	insect	insect	NN
cord-287853-cob7ur35	139	53	and	and	CC
cord-287853-cob7ur35	139	54	mammalian	mammalian	JJ
cord-287853-cob7ur35	139	55	cell	cell	NN
cord-287853-cob7ur35	139	56	lines	line	NNS