id sid tid token lemma pos cord-297469-26d8o1xk 1 1 key key NN cord-297469-26d8o1xk 1 2 : : : cord-297469-26d8o1xk 2 1 cord-297469 cord-297469 NNP cord-297469-26d8o1xk 2 2 - - HYPH cord-297469-26d8o1xk 2 3 26d8o1xk 26d8o1xk CD cord-297469-26d8o1xk 2 4 authors author NNS cord-297469-26d8o1xk 2 5 : : : cord-297469-26d8o1xk 2 6 Choi Choi NNP cord-297469-26d8o1xk 2 7 , , , cord-297469-26d8o1xk 2 8 Won Won NNP cord-297469-26d8o1xk 2 9 Hyung Hyung NNP cord-297469-26d8o1xk 2 10 ; ; : cord-297469-26d8o1xk 2 11 Lee Lee NNP cord-297469-26d8o1xk 2 12 , , , cord-297469-26d8o1xk 2 13 In in IN cord-297469-26d8o1xk 2 14 Ah Ah NNP cord-297469-26d8o1xk 2 15 title title NN cord-297469-26d8o1xk 2 16 : : : cord-297469-26d8o1xk 3 1 The the DT cord-297469-26d8o1xk 3 2 Mechanism Mechanism NNP cord-297469-26d8o1xk 3 3 of of IN cord-297469-26d8o1xk 3 4 Action Action NNP cord-297469-26d8o1xk 3 5 of of IN cord-297469-26d8o1xk 3 6 Ursolic Ursolic NNP cord-297469-26d8o1xk 3 7 Acid Acid NNP cord-297469-26d8o1xk 3 8 as as IN cord-297469-26d8o1xk 3 9 a a DT cord-297469-26d8o1xk 3 10 Potential potential JJ cord-297469-26d8o1xk 3 11 Anti Anti NNP cord-297469-26d8o1xk 3 12 - - JJ cord-297469-26d8o1xk 3 13 Toxoplasmosis Toxoplasmosis NNP cord-297469-26d8o1xk 3 14 Agent Agent NNP cord-297469-26d8o1xk 3 15 , , , cord-297469-26d8o1xk 3 16 and and CC cord-297469-26d8o1xk 3 17 Its -PRON- PRP$ cord-297469-26d8o1xk 3 18 Immunomodulatory Immunomodulatory NNP cord-297469-26d8o1xk 3 19 Effects effect NNS cord-297469-26d8o1xk 3 20 date date NN cord-297469-26d8o1xk 3 21 : : : cord-297469-26d8o1xk 3 22 2019 2019 CD cord-297469-26d8o1xk 3 23 - - HYPH cord-297469-26d8o1xk 3 24 05 05 CD cord-297469-26d8o1xk 3 25 - - HYPH cord-297469-26d8o1xk 3 26 09 09 CD cord-297469-26d8o1xk 3 27 journal journal NN cord-297469-26d8o1xk 3 28 : : : cord-297469-26d8o1xk 4 1 Pathogens pathogen NNS cord-297469-26d8o1xk 5 1 DOI DOI NNP cord-297469-26d8o1xk 5 2 : : : cord-297469-26d8o1xk 6 1 10.3390 10.3390 CD cord-297469-26d8o1xk 6 2 / / SYM cord-297469-26d8o1xk 6 3 pathogens8020061 pathogens8020061 NN cord-297469-26d8o1xk 7 1 sha sha NNP cord-297469-26d8o1xk 7 2 : : : cord-297469-26d8o1xk 8 1 b5b87074a3f33c0a1408a01218e1776ae85f5b31 b5b87074a3f33c0a1408a01218e1776ae85f5b31 NNP cord-297469-26d8o1xk 8 2 doc_id doc_id NNP cord-297469-26d8o1xk 8 3 : : : cord-297469-26d8o1xk 9 1 297469 297469 CD cord-297469-26d8o1xk 9 2 cord_uid cord_uid NNS cord-297469-26d8o1xk 9 3 : : : cord-297469-26d8o1xk 9 4 26d8o1xk 26d8o1xk CD cord-297469-26d8o1xk 10 1 This this DT cord-297469-26d8o1xk 10 2 study study NN cord-297469-26d8o1xk 10 3 was be VBD cord-297469-26d8o1xk 10 4 performed perform VBN cord-297469-26d8o1xk 10 5 to to TO cord-297469-26d8o1xk 10 6 investigate investigate VB cord-297469-26d8o1xk 10 7 the the DT cord-297469-26d8o1xk 10 8 mechanism mechanism NN cord-297469-26d8o1xk 10 9 of of IN cord-297469-26d8o1xk 10 10 action action NN cord-297469-26d8o1xk 10 11 of of IN cord-297469-26d8o1xk 10 12 ursolic ursolic JJ cord-297469-26d8o1xk 10 13 acid acid NN cord-297469-26d8o1xk 10 14 in in IN cord-297469-26d8o1xk 10 15 terms term NNS cord-297469-26d8o1xk 10 16 of of IN cord-297469-26d8o1xk 10 17 anti anti JJ cord-297469-26d8o1xk 10 18 - - JJ cord-297469-26d8o1xk 10 19 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 10 20 gondii gondii NN cord-297469-26d8o1xk 10 21 effects effect NNS cord-297469-26d8o1xk 10 22 , , , cord-297469-26d8o1xk 10 23 including include VBG cord-297469-26d8o1xk 10 24 immunomodulatory immunomodulatory JJ cord-297469-26d8o1xk 10 25 effects effect NNS cord-297469-26d8o1xk 10 26 . . . cord-297469-26d8o1xk 11 1 We -PRON- PRP cord-297469-26d8o1xk 11 2 evaluated evaluate VBD cord-297469-26d8o1xk 11 3 the the DT cord-297469-26d8o1xk 11 4 anti anti JJ cord-297469-26d8o1xk 11 5 - - JJ cord-297469-26d8o1xk 11 6 T. t. JJ cord-297469-26d8o1xk 11 7 gondii gondii NN cord-297469-26d8o1xk 11 8 effects effect NNS cord-297469-26d8o1xk 11 9 of of IN cord-297469-26d8o1xk 11 10 ursolic ursolic JJ cord-297469-26d8o1xk 11 11 acid acid NN cord-297469-26d8o1xk 11 12 , , , cord-297469-26d8o1xk 11 13 and and CC cord-297469-26d8o1xk 11 14 analyzed analyze VBD cord-297469-26d8o1xk 11 15 the the DT cord-297469-26d8o1xk 11 16 production production NN cord-297469-26d8o1xk 11 17 of of IN cord-297469-26d8o1xk 11 18 nitric nitric NN cord-297469-26d8o1xk 11 19 oxide oxide NN cord-297469-26d8o1xk 11 20 ( ( -LRB- cord-297469-26d8o1xk 11 21 NO no UH cord-297469-26d8o1xk 11 22 ) ) -RRB- cord-297469-26d8o1xk 11 23 , , , cord-297469-26d8o1xk 11 24 reactive reactive JJ cord-297469-26d8o1xk 11 25 oxygen oxygen NN cord-297469-26d8o1xk 11 26 species specie NNS cord-297469-26d8o1xk 11 27 ( ( -LRB- cord-297469-26d8o1xk 11 28 ROS ROS NNP cord-297469-26d8o1xk 11 29 ) ) -RRB- cord-297469-26d8o1xk 11 30 , , , cord-297469-26d8o1xk 11 31 and and CC cord-297469-26d8o1xk 11 32 cytokines cytokine NNS cord-297469-26d8o1xk 11 33 through through IN cord-297469-26d8o1xk 11 34 co co JJ cord-297469-26d8o1xk 11 35 - - JJ cord-297469-26d8o1xk 11 36 cultured cultured JJ cord-297469-26d8o1xk 11 37 immune immune JJ cord-297469-26d8o1xk 11 38 cells cell NNS cord-297469-26d8o1xk 11 39 , , , cord-297469-26d8o1xk 11 40 as as RB cord-297469-26d8o1xk 11 41 well well RB cord-297469-26d8o1xk 11 42 as as IN cord-297469-26d8o1xk 11 43 the the DT cord-297469-26d8o1xk 11 44 expression expression NN cord-297469-26d8o1xk 11 45 of of IN cord-297469-26d8o1xk 11 46 intracellular intracellular JJ cord-297469-26d8o1xk 11 47 organelles organelle NNS cord-297469-26d8o1xk 11 48 of of IN cord-297469-26d8o1xk 11 49 T. t. NN cord-297469-26d8o1xk 11 50 gondii gondii NN cord-297469-26d8o1xk 11 51 . . . cord-297469-26d8o1xk 12 1 The the DT cord-297469-26d8o1xk 12 2 subcellular subcellular JJ cord-297469-26d8o1xk 12 3 organelles organelle NNS cord-297469-26d8o1xk 12 4 and and CC cord-297469-26d8o1xk 12 5 granules granule NNS cord-297469-26d8o1xk 12 6 of of IN cord-297469-26d8o1xk 12 7 T. t. NN cord-297469-26d8o1xk 12 8 gondii gondii NN cord-297469-26d8o1xk 12 9 , , , cord-297469-26d8o1xk 12 10 particularly particularly RB cord-297469-26d8o1xk 12 11 rhoptry rhoptry NN cord-297469-26d8o1xk 12 12 protein protein NN cord-297469-26d8o1xk 12 13 18 18 CD cord-297469-26d8o1xk 12 14 , , , cord-297469-26d8o1xk 12 15 microneme microneme NNP cord-297469-26d8o1xk 12 16 protein protein NNP cord-297469-26d8o1xk 12 17 8 8 CD cord-297469-26d8o1xk 12 18 , , , cord-297469-26d8o1xk 12 19 and and CC cord-297469-26d8o1xk 12 20 inner inner JJ cord-297469-26d8o1xk 12 21 membrane membrane NN cord-297469-26d8o1xk 12 22 complex complex JJ cord-297469-26d8o1xk 12 23 sub sub JJ cord-297469-26d8o1xk 12 24 - - JJ cord-297469-26d8o1xk 12 25 compartment compartment JJ cord-297469-26d8o1xk 12 26 protein protein NN cord-297469-26d8o1xk 12 27 3 3 CD cord-297469-26d8o1xk 12 28 , , , cord-297469-26d8o1xk 12 29 were be VBD cord-297469-26d8o1xk 12 30 markedly markedly RB cord-297469-26d8o1xk 12 31 decreased decrease VBN cord-297469-26d8o1xk 12 32 when when WRB cord-297469-26d8o1xk 12 33 T. T. NNP cord-297469-26d8o1xk 12 34 gondii gondii NNP cord-297469-26d8o1xk 12 35 was be VBD cord-297469-26d8o1xk 12 36 treated treat VBN cord-297469-26d8o1xk 12 37 with with IN cord-297469-26d8o1xk 12 38 ursolic ursolic JJ cord-297469-26d8o1xk 12 39 acid acid NN cord-297469-26d8o1xk 12 40 , , , cord-297469-26d8o1xk 12 41 and and CC cord-297469-26d8o1xk 12 42 their -PRON- PRP$ cord-297469-26d8o1xk 12 43 expressions expression NNS cord-297469-26d8o1xk 12 44 were be VBD cord-297469-26d8o1xk 12 45 effectively effectively RB cord-297469-26d8o1xk 12 46 inhibited inhibit VBN cord-297469-26d8o1xk 12 47 . . . cord-297469-26d8o1xk 13 1 Furthermore furthermore RB cord-297469-26d8o1xk 13 2 , , , cord-297469-26d8o1xk 13 3 ursolic ursolic JJ cord-297469-26d8o1xk 13 4 acid acid NN cord-297469-26d8o1xk 13 5 effectively effectively RB cord-297469-26d8o1xk 13 6 increased increase VBD cord-297469-26d8o1xk 13 7 the the DT cord-297469-26d8o1xk 13 8 production production NN cord-297469-26d8o1xk 13 9 of of IN cord-297469-26d8o1xk 13 10 NO no NN cord-297469-26d8o1xk 13 11 , , , cord-297469-26d8o1xk 13 12 ROS ROS NNP cord-297469-26d8o1xk 13 13 , , , cord-297469-26d8o1xk 13 14 interleukin interleukin NN cord-297469-26d8o1xk 13 15 ( ( -LRB- cord-297469-26d8o1xk 13 16 IL)-10 il)-10 FW cord-297469-26d8o1xk 13 17 , , , cord-297469-26d8o1xk 13 18 IL-12 IL-12 NNP cord-297469-26d8o1xk 13 19 , , , cord-297469-26d8o1xk 13 20 granulocyte granulocyte NN cord-297469-26d8o1xk 13 21 macrophage macrophage NN cord-297469-26d8o1xk 13 22 colony colony NN cord-297469-26d8o1xk 13 23 stimulating stimulate VBG cord-297469-26d8o1xk 13 24 factor factor NN cord-297469-26d8o1xk 13 25 ( ( -LRB- cord-297469-26d8o1xk 13 26 GM GM NNP cord-297469-26d8o1xk 13 27 - - HYPH cord-297469-26d8o1xk 13 28 CSF CSF NNP cord-297469-26d8o1xk 13 29 ) ) -RRB- cord-297469-26d8o1xk 13 30 , , , cord-297469-26d8o1xk 13 31 and and CC cord-297469-26d8o1xk 13 32 interferon interferon NN cord-297469-26d8o1xk 13 33 - - HYPH cord-297469-26d8o1xk 13 34 β β XX cord-297469-26d8o1xk 13 35 , , , cord-297469-26d8o1xk 13 36 while while IN cord-297469-26d8o1xk 13 37 reducing reduce VBG cord-297469-26d8o1xk 13 38 the the DT cord-297469-26d8o1xk 13 39 expression expression NN cord-297469-26d8o1xk 13 40 of of IN cord-297469-26d8o1xk 13 41 IL-1β IL-1β NNP cord-297469-26d8o1xk 13 42 , , , cord-297469-26d8o1xk 13 43 IL-6 IL-6 NNP cord-297469-26d8o1xk 13 44 , , , cord-297469-26d8o1xk 13 45 tumor tumor NN cord-297469-26d8o1xk 13 46 necrosis necrosis NN cord-297469-26d8o1xk 13 47 factor factor NN cord-297469-26d8o1xk 13 48 alpha alpha NN cord-297469-26d8o1xk 13 49 ( ( -LRB- cord-297469-26d8o1xk 13 50 TNF TNF NNP cord-297469-26d8o1xk 13 51 - - HYPH cord-297469-26d8o1xk 13 52 α α NNP cord-297469-26d8o1xk 13 53 ) ) -RRB- cord-297469-26d8o1xk 13 54 , , , cord-297469-26d8o1xk 13 55 and and CC cord-297469-26d8o1xk 13 56 transforming transform VBG cord-297469-26d8o1xk 13 57 growth growth NN cord-297469-26d8o1xk 13 58 factor factor NN cord-297469-26d8o1xk 13 59 beta beta NN cord-297469-26d8o1xk 13 60 1 1 CD cord-297469-26d8o1xk 13 61 ( ( -LRB- cord-297469-26d8o1xk 13 62 TGF TGF NNP cord-297469-26d8o1xk 13 63 - - HYPH cord-297469-26d8o1xk 13 64 β1 β1 NNP cord-297469-26d8o1xk 13 65 ) ) -RRB- cord-297469-26d8o1xk 13 66 in in IN cord-297469-26d8o1xk 13 67 T. T. NNP cord-297469-26d8o1xk 13 68 gondii gondii NN cord-297469-26d8o1xk 13 69 - - HYPH cord-297469-26d8o1xk 13 70 infected infect VBN cord-297469-26d8o1xk 13 71 immune immune JJ cord-297469-26d8o1xk 13 72 cells cell NNS cord-297469-26d8o1xk 13 73 . . . cord-297469-26d8o1xk 14 1 These these DT cord-297469-26d8o1xk 14 2 results result NNS cord-297469-26d8o1xk 14 3 demonstrate demonstrate VBP cord-297469-26d8o1xk 14 4 that that IN cord-297469-26d8o1xk 14 5 ursolic ursolic JJ cord-297469-26d8o1xk 14 6 acid acid NN cord-297469-26d8o1xk 14 7 not not RB cord-297469-26d8o1xk 14 8 only only RB cord-297469-26d8o1xk 14 9 causes cause VBZ cord-297469-26d8o1xk 14 10 anti anti JJ cord-297469-26d8o1xk 14 11 - - JJ cord-297469-26d8o1xk 14 12 T. t. JJ cord-297469-26d8o1xk 14 13 gondii gondii NN cord-297469-26d8o1xk 14 14 activity activity NN cord-297469-26d8o1xk 14 15 / / SYM cord-297469-26d8o1xk 14 16 action action NN cord-297469-26d8o1xk 14 17 by by IN cord-297469-26d8o1xk 14 18 effectively effectively RB cord-297469-26d8o1xk 14 19 inhibiting inhibit VBG cord-297469-26d8o1xk 14 20 the the DT cord-297469-26d8o1xk 14 21 survival survival NN cord-297469-26d8o1xk 14 22 of of IN cord-297469-26d8o1xk 14 23 T. t. NN cord-297469-26d8o1xk 14 24 gondii gondii NNP cord-297469-26d8o1xk 14 25 and and CC cord-297469-26d8o1xk 14 26 the the DT cord-297469-26d8o1xk 14 27 subcellular subcellular JJ cord-297469-26d8o1xk 14 28 organelles organelle NNS cord-297469-26d8o1xk 14 29 of of IN cord-297469-26d8o1xk 14 30 T. t. NN cord-297469-26d8o1xk 14 31 gondii gondii NN cord-297469-26d8o1xk 14 32 , , , cord-297469-26d8o1xk 14 33 but but CC cord-297469-26d8o1xk 14 34 also also RB cord-297469-26d8o1xk 14 35 induces induce VBZ cord-297469-26d8o1xk 14 36 specific specific JJ cord-297469-26d8o1xk 14 37 immunomodulatory immunomodulatory JJ cord-297469-26d8o1xk 14 38 effects effect NNS cord-297469-26d8o1xk 14 39 in in IN cord-297469-26d8o1xk 14 40 T. T. NNP cord-297469-26d8o1xk 14 41 gondii gondii NN cord-297469-26d8o1xk 14 42 - - HYPH cord-297469-26d8o1xk 14 43 infected infect VBN cord-297469-26d8o1xk 14 44 immune immune JJ cord-297469-26d8o1xk 14 45 cells cell NNS cord-297469-26d8o1xk 14 46 . . . cord-297469-26d8o1xk 15 1 Therefore therefore RB cord-297469-26d8o1xk 15 2 , , , cord-297469-26d8o1xk 15 3 this this DT cord-297469-26d8o1xk 15 4 study study NN cord-297469-26d8o1xk 15 5 indicates indicate VBZ cord-297469-26d8o1xk 15 6 that that IN cord-297469-26d8o1xk 15 7 ursolic ursolic JJ cord-297469-26d8o1xk 15 8 acid acid NN cord-297469-26d8o1xk 15 9 can can MD cord-297469-26d8o1xk 15 10 be be VB cord-297469-26d8o1xk 15 11 effectively effectively RB cord-297469-26d8o1xk 15 12 utilized utilize VBN cord-297469-26d8o1xk 15 13 as as IN cord-297469-26d8o1xk 15 14 a a DT cord-297469-26d8o1xk 15 15 potential potential JJ cord-297469-26d8o1xk 15 16 candidate candidate NN cord-297469-26d8o1xk 15 17 agent agent NN cord-297469-26d8o1xk 15 18 for for IN cord-297469-26d8o1xk 15 19 developing develop VBG cord-297469-26d8o1xk 15 20 novel novel JJ cord-297469-26d8o1xk 15 21 anti anti JJ cord-297469-26d8o1xk 15 22 - - JJ cord-297469-26d8o1xk 15 23 toxoplasmosis toxoplasmosis JJ cord-297469-26d8o1xk 15 24 drugs drug NNS cord-297469-26d8o1xk 15 25 , , , cord-297469-26d8o1xk 15 26 and and CC cord-297469-26d8o1xk 15 27 has have VBZ cord-297469-26d8o1xk 15 28 immunomodulatory immunomodulatory JJ cord-297469-26d8o1xk 15 29 activity activity NN cord-297469-26d8o1xk 15 30 . . . cord-297469-26d8o1xk 16 1 Recently recently RB cord-297469-26d8o1xk 16 2 , , , cord-297469-26d8o1xk 16 3 zoonotic zoonotic JJ cord-297469-26d8o1xk 16 4 diseases disease NNS cord-297469-26d8o1xk 16 5 have have VBP cord-297469-26d8o1xk 16 6 been be VBN cord-297469-26d8o1xk 16 7 consistently consistently RB cord-297469-26d8o1xk 16 8 occurring occur VBG cord-297469-26d8o1xk 16 9 in in IN cord-297469-26d8o1xk 16 10 different different JJ cord-297469-26d8o1xk 16 11 countries country NNS cord-297469-26d8o1xk 16 12 worldwide worldwide RB cord-297469-26d8o1xk 16 13 , , , cord-297469-26d8o1xk 16 14 causing cause VBG cord-297469-26d8o1xk 16 15 serious serious JJ cord-297469-26d8o1xk 16 16 threats threat NNS cord-297469-26d8o1xk 16 17 in in IN cord-297469-26d8o1xk 16 18 many many JJ cord-297469-26d8o1xk 16 19 countries country NNS cord-297469-26d8o1xk 16 20 and and CC cord-297469-26d8o1xk 16 21 to to IN cord-297469-26d8o1xk 16 22 humans human NNS cord-297469-26d8o1xk 16 23 globally globally RB cord-297469-26d8o1xk 16 24 . . . cord-297469-26d8o1xk 17 1 In in IN cord-297469-26d8o1xk 17 2 this this DT cord-297469-26d8o1xk 17 3 respect respect NN cord-297469-26d8o1xk 17 4 , , , cord-297469-26d8o1xk 17 5 the the DT cord-297469-26d8o1xk 17 6 prevention prevention NN cord-297469-26d8o1xk 17 7 and and CC cord-297469-26d8o1xk 17 8 education education NN cord-297469-26d8o1xk 17 9 of of IN cord-297469-26d8o1xk 17 10 various various JJ cord-297469-26d8o1xk 17 11 zoonotic zoonotic JJ cord-297469-26d8o1xk 17 12 diseases disease NNS cord-297469-26d8o1xk 17 13 are be VBP cord-297469-26d8o1xk 17 14 becoming become VBG cord-297469-26d8o1xk 17 15 a a DT cord-297469-26d8o1xk 17 16 major major JJ cord-297469-26d8o1xk 17 17 issue issue NN cord-297469-26d8o1xk 17 18 . . . cord-297469-26d8o1xk 18 1 Toxoplasmosis toxoplasmosis NN cord-297469-26d8o1xk 18 2 is be VBZ cord-297469-26d8o1xk 18 3 a a DT cord-297469-26d8o1xk 18 4 parasitic parasitic JJ cord-297469-26d8o1xk 18 5 disease disease NN cord-297469-26d8o1xk 18 6 that that WDT cord-297469-26d8o1xk 18 7 is be VBZ cord-297469-26d8o1xk 18 8 induced induce VBN cord-297469-26d8o1xk 18 9 through through IN cord-297469-26d8o1xk 18 10 the the DT cord-297469-26d8o1xk 18 11 infection infection NN cord-297469-26d8o1xk 18 12 of of IN cord-297469-26d8o1xk 18 13 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 18 14 gondii gondii NN cord-297469-26d8o1xk 18 15 in in IN cord-297469-26d8o1xk 18 16 many many JJ cord-297469-26d8o1xk 18 17 countries country NNS cord-297469-26d8o1xk 18 18 worldwide worldwide RB cord-297469-26d8o1xk 18 19 as as IN cord-297469-26d8o1xk 18 20 a a DT cord-297469-26d8o1xk 18 21 zoonotic zoonotic JJ cord-297469-26d8o1xk 18 22 parasitosis parasitosis NN cord-297469-26d8o1xk 18 23 , , , cord-297469-26d8o1xk 18 24 causing cause VBG cord-297469-26d8o1xk 18 25 serious serious JJ cord-297469-26d8o1xk 18 26 diseases disease NNS cord-297469-26d8o1xk 18 27 and and CC cord-297469-26d8o1xk 18 28 chronic chronic JJ cord-297469-26d8o1xk 18 29 infection infection NN cord-297469-26d8o1xk 18 30 in in IN cord-297469-26d8o1xk 18 31 various various JJ cord-297469-26d8o1xk 18 32 sites site NNS cord-297469-26d8o1xk 18 33 of of IN cord-297469-26d8o1xk 18 34 the the DT cord-297469-26d8o1xk 18 35 human human JJ cord-297469-26d8o1xk 18 36 body body NN cord-297469-26d8o1xk 18 37 in in IN cord-297469-26d8o1xk 18 38 all all DT cord-297469-26d8o1xk 18 39 age age NN cord-297469-26d8o1xk 18 40 groups group NNS cord-297469-26d8o1xk 18 41 , , , cord-297469-26d8o1xk 18 42 including include VBG cord-297469-26d8o1xk 18 43 adults adult NNS cord-297469-26d8o1xk 18 44 and and CC cord-297469-26d8o1xk 18 45 young young JJ cord-297469-26d8o1xk 18 46 children child NNS cord-297469-26d8o1xk 18 47 as as RB cord-297469-26d8o1xk 18 48 well well RB cord-297469-26d8o1xk 18 49 as as IN cord-297469-26d8o1xk 18 50 pregnant pregnant JJ cord-297469-26d8o1xk 18 51 women woman NNS cord-297469-26d8o1xk 18 52 . . . cord-297469-26d8o1xk 19 1 In in IN cord-297469-26d8o1xk 19 2 particular particular JJ cord-297469-26d8o1xk 19 3 , , , cord-297469-26d8o1xk 19 4 because because IN cord-297469-26d8o1xk 19 5 toxoplasmosis toxoplasmosis NN cord-297469-26d8o1xk 19 6 is be VBZ cord-297469-26d8o1xk 19 7 a a DT cord-297469-26d8o1xk 19 8 zoonotic zoonotic JJ cord-297469-26d8o1xk 19 9 disease disease NN cord-297469-26d8o1xk 19 10 that that WDT cord-297469-26d8o1xk 19 11 infects infect VBZ cord-297469-26d8o1xk 19 12 humans human NNS cord-297469-26d8o1xk 19 13 through through IN cord-297469-26d8o1xk 19 14 cats cat NNS cord-297469-26d8o1xk 19 15 , , , cord-297469-26d8o1xk 19 16 many many JJ cord-297469-26d8o1xk 19 17 people people NNS cord-297469-26d8o1xk 19 18 that that WDT cord-297469-26d8o1xk 19 19 have have VBP cord-297469-26d8o1xk 19 20 cats cat NNS cord-297469-26d8o1xk 19 21 as as IN cord-297469-26d8o1xk 19 22 pets pet NNS cord-297469-26d8o1xk 19 23 , , , cord-297469-26d8o1xk 19 24 particularly particularly RB cord-297469-26d8o1xk 19 25 pregnant pregnant JJ cord-297469-26d8o1xk 19 26 women woman NNS cord-297469-26d8o1xk 19 27 , , , cord-297469-26d8o1xk 19 28 need need VBP cord-297469-26d8o1xk 19 29 to to TO cord-297469-26d8o1xk 19 30 take take VB cord-297469-26d8o1xk 19 31 caution caution NN cord-297469-26d8o1xk 19 32 in in IN cord-297469-26d8o1xk 19 33 this this DT cord-297469-26d8o1xk 19 34 regard regard NN cord-297469-26d8o1xk 19 35 . . . cord-297469-26d8o1xk 20 1 In in IN cord-297469-26d8o1xk 20 2 the the DT cord-297469-26d8o1xk 20 3 biological biological JJ cord-297469-26d8o1xk 20 4 aspect aspect NN cord-297469-26d8o1xk 20 5 , , , cord-297469-26d8o1xk 20 6 T. T. NNP cord-297469-26d8o1xk 20 7 gondii gondii NN cord-297469-26d8o1xk 20 8 not not RB cord-297469-26d8o1xk 20 9 only only RB cord-297469-26d8o1xk 20 10 has have VBZ cord-297469-26d8o1xk 20 11 intracellular intracellular JJ cord-297469-26d8o1xk 20 12 organelles organelle NNS cord-297469-26d8o1xk 20 13 such such JJ cord-297469-26d8o1xk 20 14 as as IN cord-297469-26d8o1xk 20 15 the the DT cord-297469-26d8o1xk 20 16 golgi golgi NN cord-297469-26d8o1xk 20 17 , , , cord-297469-26d8o1xk 20 18 endoplasmic endoplasmic NN cord-297469-26d8o1xk 20 19 reticulum reticulum NN cord-297469-26d8o1xk 20 20 , , , cord-297469-26d8o1xk 20 21 and and CC cord-297469-26d8o1xk 20 22 mitochondrion mitochondrion NN cord-297469-26d8o1xk 20 23 , , , cord-297469-26d8o1xk 20 24 but but CC cord-297469-26d8o1xk 20 25 also also RB cord-297469-26d8o1xk 20 26 unique unique JJ cord-297469-26d8o1xk 20 27 subcellular subcellular JJ cord-297469-26d8o1xk 20 28 organelles organelle NNS cord-297469-26d8o1xk 20 29 such such JJ cord-297469-26d8o1xk 20 30 as as IN cord-297469-26d8o1xk 20 31 the the DT cord-297469-26d8o1xk 20 32 conoid conoid NN cord-297469-26d8o1xk 20 33 , , , cord-297469-26d8o1xk 20 34 apicoplast apicoplast RB cord-297469-26d8o1xk 20 35 , , , cord-297469-26d8o1xk 20 36 surface surface NN cord-297469-26d8o1xk 20 37 antigens antigen NNS cord-297469-26d8o1xk 20 38 ( ( -LRB- cord-297469-26d8o1xk 20 39 SAGs SAGs NNP cord-297469-26d8o1xk 20 40 ) ) -RRB- cord-297469-26d8o1xk 20 41 , , , cord-297469-26d8o1xk 20 42 dense dense JJ cord-297469-26d8o1xk 20 43 granule granule NN cord-297469-26d8o1xk 20 44 proteins protein NNS cord-297469-26d8o1xk 20 45 ( ( -LRB- cord-297469-26d8o1xk 20 46 GRAs gra NNS cord-297469-26d8o1xk 20 47 ) ) -RRB- cord-297469-26d8o1xk 20 48 , , , cord-297469-26d8o1xk 20 49 rhoptries rhoptrie NNS cord-297469-26d8o1xk 20 50 , , , cord-297469-26d8o1xk 20 51 and and CC cord-297469-26d8o1xk 20 52 micronemes micronemes NNPS cord-297469-26d8o1xk 20 53 [ [ -LRB- cord-297469-26d8o1xk 20 54 1 1 CD cord-297469-26d8o1xk 20 55 ] ] -RRB- cord-297469-26d8o1xk 20 56 . . . cord-297469-26d8o1xk 21 1 T. T. NNP cord-297469-26d8o1xk 21 2 gondii gondii NNP cord-297469-26d8o1xk 21 3 has have VBZ cord-297469-26d8o1xk 21 4 an an DT cord-297469-26d8o1xk 21 5 inner inner JJ cord-297469-26d8o1xk 21 6 membrane membrane NN cord-297469-26d8o1xk 21 7 complex complex NN cord-297469-26d8o1xk 21 8 ( ( -LRB- cord-297469-26d8o1xk 21 9 IMC IMC NNP cord-297469-26d8o1xk 21 10 ) ) -RRB- cord-297469-26d8o1xk 21 11 involving involve VBG cord-297469-26d8o1xk 21 12 the the DT cord-297469-26d8o1xk 21 13 plasma plasma NN cord-297469-26d8o1xk 21 14 membrane membrane NN cord-297469-26d8o1xk 21 15 , , , cord-297469-26d8o1xk 21 16 consisting consist VBG cord-297469-26d8o1xk 21 17 of of IN cord-297469-26d8o1xk 21 18 a a DT cord-297469-26d8o1xk 21 19 unique unique JJ cord-297469-26d8o1xk 21 20 double double JJ cord-297469-26d8o1xk 21 21 membrane membrane NN cord-297469-26d8o1xk 21 22 structure structure NN cord-297469-26d8o1xk 21 23 which which WDT cord-297469-26d8o1xk 21 24 is be VBZ cord-297469-26d8o1xk 21 25 combined combine VBN cord-297469-26d8o1xk 21 26 with with IN cord-297469-26d8o1xk 21 27 a a DT cord-297469-26d8o1xk 21 28 cytoskeletal cytoskeletal JJ cord-297469-26d8o1xk 21 29 network network NN cord-297469-26d8o1xk 21 30 . . . cord-297469-26d8o1xk 22 1 The the DT cord-297469-26d8o1xk 22 2 IMC IMC NNP cord-297469-26d8o1xk 22 3 acts act VBZ cord-297469-26d8o1xk 22 4 as as IN cord-297469-26d8o1xk 22 5 a a DT cord-297469-26d8o1xk 22 6 major major JJ cord-297469-26d8o1xk 22 7 factor factor NN cord-297469-26d8o1xk 22 8 in in IN cord-297469-26d8o1xk 22 9 the the DT cord-297469-26d8o1xk 22 10 proliferation proliferation NN cord-297469-26d8o1xk 22 11 and and CC cord-297469-26d8o1xk 22 12 growth growth NN cord-297469-26d8o1xk 22 13 for for IN cord-297469-26d8o1xk 22 14 the the DT cord-297469-26d8o1xk 22 15 survival survival NN cord-297469-26d8o1xk 22 16 of of IN cord-297469-26d8o1xk 22 17 T. t. NN cord-297469-26d8o1xk 22 18 gondii gondii NN cord-297469-26d8o1xk 22 19 , , , cord-297469-26d8o1xk 22 20 as as RB cord-297469-26d8o1xk 22 21 well well RB cord-297469-26d8o1xk 22 22 as as IN cord-297469-26d8o1xk 22 23 in in IN cord-297469-26d8o1xk 22 24 motility motility NN cord-297469-26d8o1xk 22 25 and and CC cord-297469-26d8o1xk 22 26 cell cell NN cord-297469-26d8o1xk 22 27 division division NN cord-297469-26d8o1xk 22 28 , , , cord-297469-26d8o1xk 22 29 which which WDT cord-297469-26d8o1xk 22 30 has have VBZ cord-297469-26d8o1xk 22 31 been be VBN cord-297469-26d8o1xk 22 32 reported report VBN cord-297469-26d8o1xk 22 33 to to TO cord-297469-26d8o1xk 22 34 include include VB cord-297469-26d8o1xk 22 35 the the DT cord-297469-26d8o1xk 22 36 T. T. NNP cord-297469-26d8o1xk 22 37 gondii gondii NN cord-297469-26d8o1xk 22 38 - - HYPH cord-297469-26d8o1xk 22 39 infected infect VBN cord-297469-26d8o1xk 22 40 cells cell NNS cord-297469-26d8o1xk 22 41 treated treat VBN cord-297469-26d8o1xk 22 42 with with IN cord-297469-26d8o1xk 22 43 SF SF NNP cord-297469-26d8o1xk 22 44 ( ( -LRB- cord-297469-26d8o1xk 22 45 Figure figure NN cord-297469-26d8o1xk 22 46 2 2 CD cord-297469-26d8o1xk 22 47 ) ) -RRB- cord-297469-26d8o1xk 22 48 . . . cord-297469-26d8o1xk 23 1 Furthermore furthermore RB cord-297469-26d8o1xk 23 2 , , , cord-297469-26d8o1xk 23 3 it -PRON- PRP cord-297469-26d8o1xk 23 4 was be VBD cord-297469-26d8o1xk 23 5 clearly clearly RB cord-297469-26d8o1xk 23 6 shown show VBN cord-297469-26d8o1xk 23 7 that that IN cord-297469-26d8o1xk 23 8 there there EX cord-297469-26d8o1xk 23 9 were be VBD cord-297469-26d8o1xk 23 10 significant significant JJ cord-297469-26d8o1xk 23 11 differences difference NNS cord-297469-26d8o1xk 23 12 between between IN cord-297469-26d8o1xk 23 13 the the DT cord-297469-26d8o1xk 23 14 untreated untreated JJ cord-297469-26d8o1xk 23 15 T. t. NN cord-297469-26d8o1xk 23 16 gondii gondii NN cord-297469-26d8o1xk 23 17 - - HYPH cord-297469-26d8o1xk 23 18 group group NN cord-297469-26d8o1xk 23 19 and and CC cord-297469-26d8o1xk 23 20 the the DT cord-297469-26d8o1xk 23 21 experimental experimental JJ cord-297469-26d8o1xk 23 22 groups group NNS cord-297469-26d8o1xk 23 23 . . . cord-297469-26d8o1xk 24 1 In in IN cord-297469-26d8o1xk 24 2 these these DT cord-297469-26d8o1xk 24 3 aspects aspect NNS cord-297469-26d8o1xk 24 4 , , , cord-297469-26d8o1xk 24 5 it -PRON- PRP cord-297469-26d8o1xk 24 6 was be VBD cord-297469-26d8o1xk 24 7 demonstrated demonstrate VBN cord-297469-26d8o1xk 24 8 that that IN cord-297469-26d8o1xk 24 9 UA UA NNP cord-297469-26d8o1xk 24 10 effectively effectively RB cord-297469-26d8o1xk 24 11 induced induce VBD cord-297469-26d8o1xk 24 12 the the DT cord-297469-26d8o1xk 24 13 selective selective JJ cord-297469-26d8o1xk 24 14 anti anti JJ cord-297469-26d8o1xk 24 15 - - JJ cord-297469-26d8o1xk 24 16 parasitic parasitic JJ cord-297469-26d8o1xk 24 17 effect effect NN cord-297469-26d8o1xk 24 18 / / SYM cord-297469-26d8o1xk 24 19 action action NN cord-297469-26d8o1xk 24 20 compared compare VBN cord-297469-26d8o1xk 24 21 to to IN cord-297469-26d8o1xk 24 22 the the DT cord-297469-26d8o1xk 24 23 SF SF NNP cord-297469-26d8o1xk 24 24 - - HYPH cord-297469-26d8o1xk 24 25 treated treat VBN cord-297469-26d8o1xk 24 26 group group NN cord-297469-26d8o1xk 24 27 and and CC cord-297469-26d8o1xk 24 28 the the DT cord-297469-26d8o1xk 24 29 untreated untreated JJ cord-297469-26d8o1xk 24 30 group group NN cord-297469-26d8o1xk 24 31 through through IN cord-297469-26d8o1xk 24 32 a a DT cord-297469-26d8o1xk 24 33 direct direct JJ cord-297469-26d8o1xk 24 34 inhibitory inhibitory JJ cord-297469-26d8o1xk 24 35 effect effect NN cord-297469-26d8o1xk 24 36 on on IN cord-297469-26d8o1xk 24 37 the the DT cord-297469-26d8o1xk 24 38 viability viability NN cord-297469-26d8o1xk 24 39 of of IN cord-297469-26d8o1xk 24 40 T. t. NN cord-297469-26d8o1xk 24 41 gondii gondii NN cord-297469-26d8o1xk 24 42 . . . cord-297469-26d8o1xk 25 1 This this DT cord-297469-26d8o1xk 25 2 shows show VBZ cord-297469-26d8o1xk 25 3 that that IN cord-297469-26d8o1xk 25 4 UA UA NNP cord-297469-26d8o1xk 25 5 has have VBZ cord-297469-26d8o1xk 25 6 the the DT cord-297469-26d8o1xk 25 7 potential potential NN cord-297469-26d8o1xk 25 8 to to TO cord-297469-26d8o1xk 25 9 be be VB cord-297469-26d8o1xk 25 10 utilized utilize VBN cord-297469-26d8o1xk 25 11 as as IN cord-297469-26d8o1xk 25 12 an an DT cord-297469-26d8o1xk 25 13 anti anti JJ cord-297469-26d8o1xk 25 14 - - JJ cord-297469-26d8o1xk 25 15 T. t. JJ cord-297469-26d8o1xk 25 16 gondii gondii NN cord-297469-26d8o1xk 25 17 candidate candidate NN cord-297469-26d8o1xk 25 18 agent agent NN cord-297469-26d8o1xk 25 19 and/or and/or CC cord-297469-26d8o1xk 25 20 a a DT cord-297469-26d8o1xk 25 21 synergic synergic JJ cord-297469-26d8o1xk 25 22 compound compound NN cord-297469-26d8o1xk 25 23 with with IN cord-297469-26d8o1xk 25 24 the the DT cord-297469-26d8o1xk 25 25 existing exist VBG cord-297469-26d8o1xk 25 26 drugs drug NNS cord-297469-26d8o1xk 25 27 for for IN cord-297469-26d8o1xk 25 28 developing develop VBG cord-297469-26d8o1xk 25 29 novel novel JJ cord-297469-26d8o1xk 25 30 anti anti JJ cord-297469-26d8o1xk 25 31 - - JJ cord-297469-26d8o1xk 25 32 toxoplasmosis toxoplasmosis JJ cord-297469-26d8o1xk 25 33 agents agent NNS cord-297469-26d8o1xk 25 34 . . . cord-297469-26d8o1xk 26 1 Therefore therefore RB cord-297469-26d8o1xk 26 2 , , , cord-297469-26d8o1xk 26 3 these these DT cord-297469-26d8o1xk 26 4 results result NNS cord-297469-26d8o1xk 26 5 indicate indicate VBP cord-297469-26d8o1xk 26 6 that that IN cord-297469-26d8o1xk 26 7 UA UA NNP cord-297469-26d8o1xk 26 8 strongly strongly RB cord-297469-26d8o1xk 26 9 inhibits inhibit VBZ cord-297469-26d8o1xk 26 10 or or CC cord-297469-26d8o1xk 26 11 blocks block VBZ cord-297469-26d8o1xk 26 12 the the DT cord-297469-26d8o1xk 26 13 survival survival NN cord-297469-26d8o1xk 26 14 of of IN cord-297469-26d8o1xk 26 15 T. t. NN cord-297469-26d8o1xk 26 16 gondii gondii NNP cord-297469-26d8o1xk 26 17 by by IN cord-297469-26d8o1xk 26 18 effectively effectively RB cord-297469-26d8o1xk 26 19 inducing induce VBG cord-297469-26d8o1xk 26 20 anti anti JJ cord-297469-26d8o1xk 26 21 - - JJ cord-297469-26d8o1xk 26 22 T. t. JJ cord-297469-26d8o1xk 26 23 gondii gondii NN cord-297469-26d8o1xk 26 24 activity activity NN cord-297469-26d8o1xk 26 25 through through IN cord-297469-26d8o1xk 26 26 the the DT cord-297469-26d8o1xk 26 27 selective selective JJ cord-297469-26d8o1xk 26 28 inhibitory inhibitory JJ cord-297469-26d8o1xk 26 29 activity activity NN cord-297469-26d8o1xk 26 30 and/or and/or CC cord-297469-26d8o1xk 26 31 action action NN cord-297469-26d8o1xk 26 32 against against IN cord-297469-26d8o1xk 26 33 the the DT cord-297469-26d8o1xk 26 34 viability viability NN cord-297469-26d8o1xk 26 35 of of IN cord-297469-26d8o1xk 26 36 T. t. NN cord-297469-26d8o1xk 26 37 gondii gondii NN cord-297469-26d8o1xk 26 38 . . . cord-297469-26d8o1xk 27 1 the the DT cord-297469-26d8o1xk 27 2 T. T. NNP cord-297469-26d8o1xk 27 3 gondii gondii NN cord-297469-26d8o1xk 27 4 - - HYPH cord-297469-26d8o1xk 27 5 infected infect VBN cord-297469-26d8o1xk 27 6 cells cell NNS cord-297469-26d8o1xk 27 7 treated treat VBN cord-297469-26d8o1xk 27 8 with with IN cord-297469-26d8o1xk 27 9 SF SF NNP cord-297469-26d8o1xk 27 10 ( ( -LRB- cord-297469-26d8o1xk 27 11 Figure figure NN cord-297469-26d8o1xk 27 12 2 2 CD cord-297469-26d8o1xk 27 13 ) ) -RRB- cord-297469-26d8o1xk 27 14 . . . cord-297469-26d8o1xk 28 1 Furthermore furthermore RB cord-297469-26d8o1xk 28 2 , , , cord-297469-26d8o1xk 28 3 it -PRON- PRP cord-297469-26d8o1xk 28 4 was be VBD cord-297469-26d8o1xk 28 5 clearly clearly RB cord-297469-26d8o1xk 28 6 shown show VBN cord-297469-26d8o1xk 28 7 that that IN cord-297469-26d8o1xk 28 8 there there EX cord-297469-26d8o1xk 28 9 were be VBD cord-297469-26d8o1xk 28 10 significant significant JJ cord-297469-26d8o1xk 28 11 differences difference NNS cord-297469-26d8o1xk 28 12 between between IN cord-297469-26d8o1xk 28 13 the the DT cord-297469-26d8o1xk 28 14 untreated untreated JJ cord-297469-26d8o1xk 28 15 T. t. NN cord-297469-26d8o1xk 28 16 gondii gondii NN cord-297469-26d8o1xk 28 17 - - HYPH cord-297469-26d8o1xk 28 18 group group NN cord-297469-26d8o1xk 28 19 and and CC cord-297469-26d8o1xk 28 20 the the DT cord-297469-26d8o1xk 28 21 experimental experimental JJ cord-297469-26d8o1xk 28 22 groups group NNS cord-297469-26d8o1xk 28 23 . . . cord-297469-26d8o1xk 29 1 In in IN cord-297469-26d8o1xk 29 2 these these DT cord-297469-26d8o1xk 29 3 aspects aspect NNS cord-297469-26d8o1xk 29 4 , , , cord-297469-26d8o1xk 29 5 it -PRON- PRP cord-297469-26d8o1xk 29 6 was be VBD cord-297469-26d8o1xk 29 7 demonstrated demonstrate VBN cord-297469-26d8o1xk 29 8 that that IN cord-297469-26d8o1xk 29 9 UA UA NNP cord-297469-26d8o1xk 29 10 effectively effectively RB cord-297469-26d8o1xk 29 11 induced induce VBD cord-297469-26d8o1xk 29 12 the the DT cord-297469-26d8o1xk 29 13 selective selective JJ cord-297469-26d8o1xk 29 14 anti anti JJ cord-297469-26d8o1xk 29 15 - - JJ cord-297469-26d8o1xk 29 16 parasitic parasitic JJ cord-297469-26d8o1xk 29 17 effect effect NN cord-297469-26d8o1xk 29 18 / / SYM cord-297469-26d8o1xk 29 19 action action NN cord-297469-26d8o1xk 29 20 compared compare VBN cord-297469-26d8o1xk 29 21 to to IN cord-297469-26d8o1xk 29 22 the the DT cord-297469-26d8o1xk 29 23 SF SF NNP cord-297469-26d8o1xk 29 24 - - HYPH cord-297469-26d8o1xk 29 25 treated treat VBN cord-297469-26d8o1xk 29 26 group group NN cord-297469-26d8o1xk 29 27 and and CC cord-297469-26d8o1xk 29 28 the the DT cord-297469-26d8o1xk 29 29 untreated untreated JJ cord-297469-26d8o1xk 29 30 group group NN cord-297469-26d8o1xk 29 31 through through IN cord-297469-26d8o1xk 29 32 a a DT cord-297469-26d8o1xk 29 33 direct direct JJ cord-297469-26d8o1xk 29 34 inhibitory inhibitory JJ cord-297469-26d8o1xk 29 35 effect effect NN cord-297469-26d8o1xk 29 36 on on IN cord-297469-26d8o1xk 29 37 the the DT cord-297469-26d8o1xk 29 38 viability viability NN cord-297469-26d8o1xk 29 39 of of IN cord-297469-26d8o1xk 29 40 T. t. NN cord-297469-26d8o1xk 29 41 gondii gondii NN cord-297469-26d8o1xk 29 42 . . . cord-297469-26d8o1xk 30 1 This this DT cord-297469-26d8o1xk 30 2 shows show VBZ cord-297469-26d8o1xk 30 3 that that IN cord-297469-26d8o1xk 30 4 UA UA NNP cord-297469-26d8o1xk 30 5 has have VBZ cord-297469-26d8o1xk 30 6 the the DT cord-297469-26d8o1xk 30 7 potential potential NN cord-297469-26d8o1xk 30 8 to to TO cord-297469-26d8o1xk 30 9 be be VB cord-297469-26d8o1xk 30 10 utilized utilize VBN cord-297469-26d8o1xk 30 11 as as IN cord-297469-26d8o1xk 30 12 an an DT cord-297469-26d8o1xk 30 13 anti anti JJ cord-297469-26d8o1xk 30 14 - - JJ cord-297469-26d8o1xk 30 15 T. t. JJ cord-297469-26d8o1xk 30 16 gondii gondii NN cord-297469-26d8o1xk 30 17 candidate candidate NN cord-297469-26d8o1xk 30 18 agent agent NN cord-297469-26d8o1xk 30 19 and/or and/or CC cord-297469-26d8o1xk 30 20 a a DT cord-297469-26d8o1xk 30 21 synergic synergic JJ cord-297469-26d8o1xk 30 22 compound compound NN cord-297469-26d8o1xk 30 23 with with IN cord-297469-26d8o1xk 30 24 the the DT cord-297469-26d8o1xk 30 25 existing exist VBG cord-297469-26d8o1xk 30 26 drugs drug NNS cord-297469-26d8o1xk 30 27 for for IN cord-297469-26d8o1xk 30 28 developing develop VBG cord-297469-26d8o1xk 30 29 novel novel JJ cord-297469-26d8o1xk 30 30 anti anti JJ cord-297469-26d8o1xk 30 31 - - JJ cord-297469-26d8o1xk 30 32 toxoplasmosis toxoplasmosis JJ cord-297469-26d8o1xk 30 33 agents agent NNS cord-297469-26d8o1xk 30 34 . . . cord-297469-26d8o1xk 31 1 Therefore therefore RB cord-297469-26d8o1xk 31 2 , , , cord-297469-26d8o1xk 31 3 these these DT cord-297469-26d8o1xk 31 4 results result NNS cord-297469-26d8o1xk 31 5 indicate indicate VBP cord-297469-26d8o1xk 31 6 that that IN cord-297469-26d8o1xk 31 7 UA UA NNP cord-297469-26d8o1xk 31 8 strongly strongly RB cord-297469-26d8o1xk 31 9 inhibits inhibit VBZ cord-297469-26d8o1xk 31 10 or or CC cord-297469-26d8o1xk 31 11 blocks block VBZ cord-297469-26d8o1xk 31 12 the the DT cord-297469-26d8o1xk 31 13 survival survival NN cord-297469-26d8o1xk 31 14 of of IN cord-297469-26d8o1xk 31 15 T. t. NN cord-297469-26d8o1xk 31 16 gondii gondii NNP cord-297469-26d8o1xk 31 17 by by IN cord-297469-26d8o1xk 31 18 effectively effectively RB cord-297469-26d8o1xk 31 19 inducing induce VBG cord-297469-26d8o1xk 31 20 anti anti JJ cord-297469-26d8o1xk 31 21 - - JJ cord-297469-26d8o1xk 31 22 T. t. JJ cord-297469-26d8o1xk 31 23 gondii gondii NN cord-297469-26d8o1xk 31 24 activity activity NN cord-297469-26d8o1xk 31 25 through through IN cord-297469-26d8o1xk 31 26 the the DT cord-297469-26d8o1xk 31 27 selective selective JJ cord-297469-26d8o1xk 31 28 inhibitory inhibitory JJ cord-297469-26d8o1xk 31 29 activity activity NN cord-297469-26d8o1xk 31 30 and/or and/or CC cord-297469-26d8o1xk 31 31 action action NN cord-297469-26d8o1xk 31 32 against against IN cord-297469-26d8o1xk 31 33 the the DT cord-297469-26d8o1xk 31 34 viability viability NN cord-297469-26d8o1xk 31 35 of of IN cord-297469-26d8o1xk 31 36 T. t. NN cord-297469-26d8o1xk 31 37 gondii gondii NN cord-297469-26d8o1xk 31 38 . . . cord-297469-26d8o1xk 32 1 The the DT cord-297469-26d8o1xk 32 2 normal normal JJ cord-297469-26d8o1xk 32 3 lung lung NN cord-297469-26d8o1xk 32 4 cells cell NNS cord-297469-26d8o1xk 32 5 were be VBD cord-297469-26d8o1xk 32 6 infected infect VBN cord-297469-26d8o1xk 32 7 with with IN cord-297469-26d8o1xk 32 8 T. t. NN cord-297469-26d8o1xk 32 9 gondii gondii NNP cord-297469-26d8o1xk 32 10 ( ( -LRB- cord-297469-26d8o1xk 32 11 cells cell NNS cord-297469-26d8o1xk 32 12 : : : cord-297469-26d8o1xk 32 13 T. t. NN cord-297469-26d8o1xk 32 14 gondii gondii NNP cord-297469-26d8o1xk 32 15 = = SYM cord-297469-26d8o1xk 32 16 1:4 1:4 CD cord-297469-26d8o1xk 32 17 ) ) -RRB- cord-297469-26d8o1xk 32 18 , , , cord-297469-26d8o1xk 32 19 and and CC cord-297469-26d8o1xk 33 1 T. T. NNP cord-297469-26d8o1xk 33 2 gondii gondii NN cord-297469-26d8o1xk 33 3 - - HYPH cord-297469-26d8o1xk 33 4 infected infect VBN cord-297469-26d8o1xk 33 5 cells cell NNS cord-297469-26d8o1xk 33 6 were be VBD cord-297469-26d8o1xk 33 7 treated treat VBN cord-297469-26d8o1xk 33 8 with with IN cord-297469-26d8o1xk 33 9 different different JJ cord-297469-26d8o1xk 33 10 concentrations concentration NNS cord-297469-26d8o1xk 33 11 ( ( -LRB- cord-297469-26d8o1xk 33 12 12.5 12.5 CD cord-297469-26d8o1xk 33 13 - - SYM cord-297469-26d8o1xk 33 14 200 200 CD cord-297469-26d8o1xk 33 15 µg µg NN cord-297469-26d8o1xk 33 16 / / SYM cord-297469-26d8o1xk 33 17 mL mL NNP cord-297469-26d8o1xk 33 18 ) ) -RRB- cord-297469-26d8o1xk 33 19 of of IN cord-297469-26d8o1xk 33 20 ursolic ursolic JJ cord-297469-26d8o1xk 33 21 acid acid NNP cord-297469-26d8o1xk 33 22 ( ( -LRB- cord-297469-26d8o1xk 33 23 UA UA NNP cord-297469-26d8o1xk 33 24 ) ) -RRB- cord-297469-26d8o1xk 33 25 and and CC cord-297469-26d8o1xk 33 26 sulfadiazine sulfadiazine NNP cord-297469-26d8o1xk 33 27 ( ( -LRB- cord-297469-26d8o1xk 33 28 SF SF NNP cord-297469-26d8o1xk 33 29 ) ) -RRB- cord-297469-26d8o1xk 33 30 at at IN cord-297469-26d8o1xk 33 31 37 37 CD cord-297469-26d8o1xk 33 32 • • NN cord-297469-26d8o1xk 33 33 C C NNP cord-297469-26d8o1xk 33 34 for for IN cord-297469-26d8o1xk 33 35 24 24 CD cord-297469-26d8o1xk 33 36 h h NN cord-297469-26d8o1xk 33 37 , , , cord-297469-26d8o1xk 33 38 respectively respectively RB cord-297469-26d8o1xk 33 39 ; ; : cord-297469-26d8o1xk 33 40 their -PRON- PRP$ cord-297469-26d8o1xk 33 41 survival survival NN cord-297469-26d8o1xk 33 42 rates rate NNS cord-297469-26d8o1xk 33 43 were be VBD cord-297469-26d8o1xk 33 44 inhibited inhibit VBN cord-297469-26d8o1xk 33 45 a a DT cord-297469-26d8o1xk 33 46 dose dose NN cord-297469-26d8o1xk 33 47 - - HYPH cord-297469-26d8o1xk 33 48 dependent dependent JJ cord-297469-26d8o1xk 33 49 manner manner NN cord-297469-26d8o1xk 33 50 . . . cord-297469-26d8o1xk 34 1 The the DT cord-297469-26d8o1xk 34 2 results result NNS cord-297469-26d8o1xk 34 3 are be VBP cord-297469-26d8o1xk 34 4 presented present VBN cord-297469-26d8o1xk 34 5 as as IN cord-297469-26d8o1xk 34 6 a a DT cord-297469-26d8o1xk 34 7 percentage percentage NN cord-297469-26d8o1xk 34 8 of of IN cord-297469-26d8o1xk 34 9 the the DT cord-297469-26d8o1xk 34 10 untreated untreated JJ cord-297469-26d8o1xk 34 11 normal normal JJ cord-297469-26d8o1xk 34 12 group group NN cord-297469-26d8o1xk 34 13 . . . cord-297469-26d8o1xk 35 1 * * NFP cord-297469-26d8o1xk 35 2 p p XX cord-297469-26d8o1xk 35 3 < < XX cord-297469-26d8o1xk 35 4 0.05 0.05 CD cord-297469-26d8o1xk 35 5 was be VBD cord-297469-26d8o1xk 35 6 considered consider VBN cord-297469-26d8o1xk 35 7 to to TO cord-297469-26d8o1xk 35 8 be be VB cord-297469-26d8o1xk 35 9 significant significant JJ cord-297469-26d8o1xk 35 10 . . . cord-297469-26d8o1xk 36 1 T. T. NNP cord-297469-26d8o1xk 36 2 gondii gondii NNP cord-297469-26d8o1xk 36 3 causes cause VBZ cord-297469-26d8o1xk 36 4 unique unique JJ cord-297469-26d8o1xk 36 5 anti anti JJ cord-297469-26d8o1xk 36 6 - - JJ cord-297469-26d8o1xk 36 7 apoptotic apoptotic JJ cord-297469-26d8o1xk 36 8 features feature NNS cord-297469-26d8o1xk 36 9 and and CC cord-297469-26d8o1xk 36 10 parasitic parasitic JJ cord-297469-26d8o1xk 36 11 survival survival NN cord-297469-26d8o1xk 36 12 cycles cycle NNS cord-297469-26d8o1xk 36 13 or or CC cord-297469-26d8o1xk 36 14 stages stage NNS cord-297469-26d8o1xk 36 15 , , , cord-297469-26d8o1xk 36 16 such such JJ cord-297469-26d8o1xk 36 17 as as IN cord-297469-26d8o1xk 36 18 the the DT cord-297469-26d8o1xk 36 19 inactivation inactivation NN cord-297469-26d8o1xk 36 20 of of IN cord-297469-26d8o1xk 36 21 apoptotic apoptotic JJ cord-297469-26d8o1xk 36 22 proteins protein NNS cord-297469-26d8o1xk 36 23 during during IN cord-297469-26d8o1xk 36 24 the the DT cord-297469-26d8o1xk 36 25 parasitic parasitic JJ cord-297469-26d8o1xk 36 26 life life NN cord-297469-26d8o1xk 36 27 - - HYPH cord-297469-26d8o1xk 36 28 cycle cycle NN cord-297469-26d8o1xk 36 29 in in IN cord-297469-26d8o1xk 36 30 host host NN cord-297469-26d8o1xk 36 31 cells cell NNS cord-297469-26d8o1xk 36 32 after after IN cord-297469-26d8o1xk 36 33 infection infection NN cord-297469-26d8o1xk 36 34 , , , cord-297469-26d8o1xk 36 35 showing show VBG cord-297469-26d8o1xk 36 36 critical critical JJ cord-297469-26d8o1xk 36 37 roles role NNS cord-297469-26d8o1xk 36 38 during during IN cord-297469-26d8o1xk 36 39 the the DT cord-297469-26d8o1xk 36 40 proliferation proliferation NN cord-297469-26d8o1xk 36 41 and and CC cord-297469-26d8o1xk 36 42 survival survival NN cord-297469-26d8o1xk 36 43 of of IN cord-297469-26d8o1xk 36 44 T. t. NN cord-297469-26d8o1xk 36 45 gondii gondii NNP cord-297469-26d8o1xk 36 46 . . . cord-297469-26d8o1xk 37 1 In in IN cord-297469-26d8o1xk 37 2 particular particular JJ cord-297469-26d8o1xk 37 3 , , , cord-297469-26d8o1xk 37 4 the the DT cord-297469-26d8o1xk 37 5 PVM PVM NNP cord-297469-26d8o1xk 37 6 , , , cord-297469-26d8o1xk 37 7 that that WDT cord-297469-26d8o1xk 37 8 functions function VBZ cord-297469-26d8o1xk 37 9 as as IN cord-297469-26d8o1xk 37 10 a a DT cord-297469-26d8o1xk 37 11 critical critical JJ cord-297469-26d8o1xk 37 12 indicator indicator NN cord-297469-26d8o1xk 37 13 during during IN cord-297469-26d8o1xk 37 14 the the DT cord-297469-26d8o1xk 37 15 proliferation proliferation NN cord-297469-26d8o1xk 37 16 stage stage NN cord-297469-26d8o1xk 37 17 of of IN cord-297469-26d8o1xk 37 18 T. t. NN cord-297469-26d8o1xk 37 19 gondii gondii NN cord-297469-26d8o1xk 37 20 , , , cord-297469-26d8o1xk 37 21 is be VBZ cord-297469-26d8o1xk 37 22 activated activate VBN cord-297469-26d8o1xk 37 23 in in IN cord-297469-26d8o1xk 37 24 a a DT cord-297469-26d8o1xk 37 25 time time NN cord-297469-26d8o1xk 37 26 - - HYPH cord-297469-26d8o1xk 37 27 dependent dependent JJ cord-297469-26d8o1xk 37 28 manner manner NN cord-297469-26d8o1xk 37 29 after after IN cord-297469-26d8o1xk 37 30 cell cell NN cord-297469-26d8o1xk 37 31 invasion invasion NN cord-297469-26d8o1xk 37 32 of of IN cord-297469-26d8o1xk 37 33 T. t. NN cord-297469-26d8o1xk 37 34 gondii gondii NNP cord-297469-26d8o1xk 37 35 , , , cord-297469-26d8o1xk 37 36 which which WDT cord-297469-26d8o1xk 37 37 causes cause VBZ cord-297469-26d8o1xk 37 38 finally finally RB cord-297469-26d8o1xk 37 39 the the DT cord-297469-26d8o1xk 37 40 proliferation proliferation NN cord-297469-26d8o1xk 37 41 and and CC cord-297469-26d8o1xk 37 42 the the DT cord-297469-26d8o1xk 37 43 growth growth NN cord-297469-26d8o1xk 37 44 of of IN cord-297469-26d8o1xk 37 45 T. t. NN cord-297469-26d8o1xk 37 46 gondii gondii NNP cord-297469-26d8o1xk 37 47 . . . cord-297469-26d8o1xk 38 1 In in IN cord-297469-26d8o1xk 38 2 this this DT cord-297469-26d8o1xk 38 3 aspect aspect NN cord-297469-26d8o1xk 38 4 , , , cord-297469-26d8o1xk 38 5 we -PRON- PRP cord-297469-26d8o1xk 38 6 investigated investigate VBD cord-297469-26d8o1xk 38 7 the the DT cord-297469-26d8o1xk 38 8 inhibitory inhibitory JJ cord-297469-26d8o1xk 38 9 action action NN cord-297469-26d8o1xk 38 10 of of IN cord-297469-26d8o1xk 38 11 UA UA NNP cord-297469-26d8o1xk 38 12 against against IN cord-297469-26d8o1xk 38 13 subcellular subcellular JJ cord-297469-26d8o1xk 38 14 organelles organelle NNS cord-297469-26d8o1xk 38 15 such such JJ cord-297469-26d8o1xk 38 16 as as IN cord-297469-26d8o1xk 38 17 rhoptries rhoptrie NNS cord-297469-26d8o1xk 38 18 , , , cord-297469-26d8o1xk 38 19 micronemes micronemes NNP cord-297469-26d8o1xk 38 20 , , , cord-297469-26d8o1xk 38 21 and and CC cord-297469-26d8o1xk 38 22 inner inner JJ cord-297469-26d8o1xk 38 23 membrane membrane NN cord-297469-26d8o1xk 38 24 complex complex NN cord-297469-26d8o1xk 38 25 that that WDT cord-297469-26d8o1xk 38 26 form form VBP cord-297469-26d8o1xk 38 27 its -PRON- PRP$ cord-297469-26d8o1xk 38 28 intracellular intracellular JJ cord-297469-26d8o1xk 38 29 metabolic metabolic JJ cord-297469-26d8o1xk 38 30 network network NN cord-297469-26d8o1xk 38 31 as as RB cord-297469-26d8o1xk 38 32 well well RB cord-297469-26d8o1xk 38 33 as as IN cord-297469-26d8o1xk 38 34 the the DT cord-297469-26d8o1xk 38 35 homeostasis homeostasis NN cord-297469-26d8o1xk 38 36 of of IN cord-297469-26d8o1xk 38 37 T. t. NN cord-297469-26d8o1xk 38 38 gondii gondii NN cord-297469-26d8o1xk 38 39 . . . cord-297469-26d8o1xk 39 1 As as IN cord-297469-26d8o1xk 39 2 shown show VBN cord-297469-26d8o1xk 39 3 in in IN cord-297469-26d8o1xk 39 4 Figure Figure NNP cord-297469-26d8o1xk 39 5 3 3 CD cord-297469-26d8o1xk 39 6 , , , cord-297469-26d8o1xk 39 7 when when WRB cord-297469-26d8o1xk 39 8 T. T. NNP cord-297469-26d8o1xk 39 9 gondii gondii NNP cord-297469-26d8o1xk 39 10 was be VBD cord-297469-26d8o1xk 39 11 treated treat VBN cord-297469-26d8o1xk 39 12 with with IN cord-297469-26d8o1xk 39 13 different different JJ cord-297469-26d8o1xk 39 14 concentrations concentration NNS cord-297469-26d8o1xk 39 15 ( ( -LRB- cord-297469-26d8o1xk 39 16 50 50 CD cord-297469-26d8o1xk 39 17 and and CC cord-297469-26d8o1xk 39 18 100 100 CD cord-297469-26d8o1xk 39 19 µg µg NN cord-297469-26d8o1xk 39 20 / / SYM cord-297469-26d8o1xk 39 21 mL ml NN cord-297469-26d8o1xk 39 22 ) ) -RRB- cord-297469-26d8o1xk 39 23 of of IN cord-297469-26d8o1xk 39 24 UA UA NNP cord-297469-26d8o1xk 39 25 and and CC cord-297469-26d8o1xk 39 26 SF SF NNP cord-297469-26d8o1xk 39 27 , , , cord-297469-26d8o1xk 39 28 respectively respectively RB cord-297469-26d8o1xk 39 29 , , , cord-297469-26d8o1xk 39 30 the the DT cord-297469-26d8o1xk 39 31 intracellular intracellular JJ cord-297469-26d8o1xk 39 32 organelles organelle NNS cord-297469-26d8o1xk 39 33 ( ( -LRB- cord-297469-26d8o1xk 39 34 rhoptry rhoptry NN cord-297469-26d8o1xk 39 35 protein protein NN cord-297469-26d8o1xk 39 36 18 18 CD cord-297469-26d8o1xk 39 37 ( ( -LRB- cord-297469-26d8o1xk 39 38 ROP ROP NNP cord-297469-26d8o1xk 39 39 18 18 CD cord-297469-26d8o1xk 39 40 ) ) -RRB- cord-297469-26d8o1xk 39 41 , , , cord-297469-26d8o1xk 39 42 microneme microneme NNP cord-297469-26d8o1xk 39 43 protein protein NNP cord-297469-26d8o1xk 39 44 8 8 CD cord-297469-26d8o1xk 39 45 ( ( -LRB- cord-297469-26d8o1xk 39 46 MIC MIC NNP cord-297469-26d8o1xk 39 47 8) 8) NN cord-297469-26d8o1xk 39 48 , , , cord-297469-26d8o1xk 39 49 and and CC cord-297469-26d8o1xk 39 50 inner inner JJ cord-297469-26d8o1xk 39 51 membrane membrane NN cord-297469-26d8o1xk 39 52 complex complex JJ cord-297469-26d8o1xk 39 53 sub sub JJ cord-297469-26d8o1xk 39 54 - - JJ cord-297469-26d8o1xk 39 55 compartment compartment JJ cord-297469-26d8o1xk 39 56 protein protein NN cord-297469-26d8o1xk 39 57 3 3 CD cord-297469-26d8o1xk 39 58 ( ( -LRB- cord-297469-26d8o1xk 39 59 IMC IMC NNP cord-297469-26d8o1xk 39 60 sub-3 sub-3 NNP cord-297469-26d8o1xk 39 61 ) ) -RRB- cord-297469-26d8o1xk 39 62 ) ) -RRB- cord-297469-26d8o1xk 39 63 of of IN cord-297469-26d8o1xk 39 64 T. t. NN cord-297469-26d8o1xk 39 65 gondii gondii NNP cord-297469-26d8o1xk 39 66 were be VBD cord-297469-26d8o1xk 39 67 markedly markedly RB cord-297469-26d8o1xk 39 68 decreased decrease VBN cord-297469-26d8o1xk 39 69 in in IN cord-297469-26d8o1xk 39 70 a a DT cord-297469-26d8o1xk 39 71 dose dose NN cord-297469-26d8o1xk 39 72 - - HYPH cord-297469-26d8o1xk 39 73 dependent dependent JJ cord-297469-26d8o1xk 39 74 manner manner NN cord-297469-26d8o1xk 39 75 , , , cord-297469-26d8o1xk 39 76 and and CC cord-297469-26d8o1xk 39 77 their -PRON- PRP$ cord-297469-26d8o1xk 39 78 changes change NNS cord-297469-26d8o1xk 39 79 were be VBD cord-297469-26d8o1xk 39 80 clearly clearly RB cord-297469-26d8o1xk 39 81 observed observe VBN cord-297469-26d8o1xk 39 82 under under IN cord-297469-26d8o1xk 39 83 electrophoresis electrophoresis NN cord-297469-26d8o1xk 39 84 . . . cord-297469-26d8o1xk 40 1 In in IN cord-297469-26d8o1xk 40 2 particular particular JJ cord-297469-26d8o1xk 40 3 , , , cord-297469-26d8o1xk 40 4 it -PRON- PRP cord-297469-26d8o1xk 40 5 is be VBZ cord-297469-26d8o1xk 40 6 known know VBN cord-297469-26d8o1xk 40 7 that that IN cord-297469-26d8o1xk 40 8 rhoptry rhoptry NN cord-297469-26d8o1xk 40 9 plays play VBZ cord-297469-26d8o1xk 40 10 as as IN cord-297469-26d8o1xk 40 11 a a DT cord-297469-26d8o1xk 40 12 critical critical JJ cord-297469-26d8o1xk 40 13 factor factor NN cord-297469-26d8o1xk 40 14 when when WRB cord-297469-26d8o1xk 40 15 T. T. NNP cord-297469-26d8o1xk 40 16 gondii gondii NNP cord-297469-26d8o1xk 40 17 enters enter VBZ cord-297469-26d8o1xk 40 18 into into IN cord-297469-26d8o1xk 40 19 host host NN cord-297469-26d8o1xk 40 20 cells cell NNS cord-297469-26d8o1xk 40 21 during during IN cord-297469-26d8o1xk 40 22 invasion invasion NN cord-297469-26d8o1xk 40 23 stage stage NN cord-297469-26d8o1xk 40 24 [ [ -LRB- cord-297469-26d8o1xk 40 25 44 44 CD cord-297469-26d8o1xk 40 26 ] ] -RRB- cord-297469-26d8o1xk 40 27 [ [ -LRB- cord-297469-26d8o1xk 40 28 45 45 CD cord-297469-26d8o1xk 40 29 ] ] -RRB- cord-297469-26d8o1xk 41 1 [ [ -LRB- cord-297469-26d8o1xk 41 2 46 46 CD cord-297469-26d8o1xk 41 3 ] ] -RRB- cord-297469-26d8o1xk 41 4 [ [ -LRB- cord-297469-26d8o1xk 41 5 47 47 CD cord-297469-26d8o1xk 41 6 ] ] -RRB- cord-297469-26d8o1xk 41 7 [ [ -LRB- cord-297469-26d8o1xk 41 8 48 48 CD cord-297469-26d8o1xk 41 9 ] ] -RRB- cord-297469-26d8o1xk 41 10 . . . cord-297469-26d8o1xk 42 1 In in IN cord-297469-26d8o1xk 42 2 these these DT cord-297469-26d8o1xk 42 3 aspects aspect NNS cord-297469-26d8o1xk 42 4 , , , cord-297469-26d8o1xk 42 5 this this DT cord-297469-26d8o1xk 42 6 result result NN cord-297469-26d8o1xk 42 7 shows show VBZ cord-297469-26d8o1xk 42 8 clearly clearly RB cord-297469-26d8o1xk 42 9 that that IN cord-297469-26d8o1xk 42 10 UA UA NNP cord-297469-26d8o1xk 42 11 not not RB cord-297469-26d8o1xk 42 12 only only RB cord-297469-26d8o1xk 42 13 has have VBZ cord-297469-26d8o1xk 42 14 the the DT cord-297469-26d8o1xk 42 15 direct direct JJ cord-297469-26d8o1xk 42 16 inhibitory inhibitory JJ cord-297469-26d8o1xk 42 17 effect effect NN cord-297469-26d8o1xk 42 18 against against IN cord-297469-26d8o1xk 42 19 the the DT cord-297469-26d8o1xk 42 20 survival survival NN cord-297469-26d8o1xk 42 21 of of IN cord-297469-26d8o1xk 42 22 T. t. NN cord-297469-26d8o1xk 42 23 gondii gondii NN cord-297469-26d8o1xk 42 24 but but CC cord-297469-26d8o1xk 42 25 also also RB cord-297469-26d8o1xk 42 26 induces induce VBZ cord-297469-26d8o1xk 42 27 the the DT cord-297469-26d8o1xk 42 28 anti anti JJ cord-297469-26d8o1xk 42 29 - - JJ cord-297469-26d8o1xk 42 30 T. t. JJ cord-297469-26d8o1xk 42 31 gondii gondii NN cord-297469-26d8o1xk 42 32 effect effect NN cord-297469-26d8o1xk 42 33 by by IN cord-297469-26d8o1xk 42 34 strongly strongly RB cord-297469-26d8o1xk 42 35 blocking block VBG cord-297469-26d8o1xk 42 36 or or CC cord-297469-26d8o1xk 42 37 inhibiting inhibit VBG cord-297469-26d8o1xk 42 38 the the DT cord-297469-26d8o1xk 42 39 homeostasis homeostasis NN cord-297469-26d8o1xk 42 40 and and CC cord-297469-26d8o1xk 42 41 network network NN cord-297469-26d8o1xk 42 42 structure structure NN cord-297469-26d8o1xk 42 43 of of IN cord-297469-26d8o1xk 42 44 the the DT cord-297469-26d8o1xk 42 45 intracellular intracellular JJ cord-297469-26d8o1xk 42 46 organelles organelle NNS cord-297469-26d8o1xk 42 47 of of IN cord-297469-26d8o1xk 42 48 T. t. NN cord-297469-26d8o1xk 42 49 gondii gondii NN cord-297469-26d8o1xk 42 50 . . . cord-297469-26d8o1xk 43 1 Therefore therefore RB cord-297469-26d8o1xk 43 2 , , , cord-297469-26d8o1xk 43 3 these these DT cord-297469-26d8o1xk 43 4 results result NNS cord-297469-26d8o1xk 43 5 demonstrate demonstrate VBP cord-297469-26d8o1xk 43 6 substantial substantial JJ cord-297469-26d8o1xk 43 7 evidence evidence NN cord-297469-26d8o1xk 43 8 that that IN cord-297469-26d8o1xk 43 9 UA UA NNP cord-297469-26d8o1xk 43 10 consistently consistently RB cord-297469-26d8o1xk 43 11 causes cause VBZ cord-297469-26d8o1xk 43 12 anti anti JJ cord-297469-26d8o1xk 43 13 - - JJ cord-297469-26d8o1xk 43 14 T. t. JJ cord-297469-26d8o1xk 43 15 gondii gondii NN cord-297469-26d8o1xk 43 16 activity activity NN cord-297469-26d8o1xk 43 17 / / SYM cord-297469-26d8o1xk 43 18 action action NN cord-297469-26d8o1xk 43 19 by by IN cord-297469-26d8o1xk 43 20 effectively effectively RB cord-297469-26d8o1xk 43 21 inhibiting inhibit VBG cord-297469-26d8o1xk 43 22 the the DT cord-297469-26d8o1xk 43 23 intracellular intracellular JJ cord-297469-26d8o1xk 43 24 organelles organelle NNS cord-297469-26d8o1xk 43 25 of of IN cord-297469-26d8o1xk 43 26 T. t. NN cord-297469-26d8o1xk 43 27 gondii gondii NN cord-297469-26d8o1xk 43 28 . . . cord-297469-26d8o1xk 44 1 37 37 CD cord-297469-26d8o1xk 44 2 ° ° NN cord-297469-26d8o1xk 44 3 C c NN cord-297469-26d8o1xk 44 4 for for IN cord-297469-26d8o1xk 44 5 24 24 CD cord-297469-26d8o1xk 44 6 h h NN cord-297469-26d8o1xk 44 7 , , , cord-297469-26d8o1xk 44 8 respectively respectively RB cord-297469-26d8o1xk 44 9 ; ; : cord-297469-26d8o1xk 44 10 their -PRON- PRP$ cord-297469-26d8o1xk 44 11 survival survival NN cord-297469-26d8o1xk 44 12 rates rate NNS cord-297469-26d8o1xk 44 13 were be VBD cord-297469-26d8o1xk 44 14 inhibited inhibit VBN cord-297469-26d8o1xk 44 15 a a DT cord-297469-26d8o1xk 44 16 dose dose NN cord-297469-26d8o1xk 44 17 - - HYPH cord-297469-26d8o1xk 44 18 dependent dependent JJ cord-297469-26d8o1xk 44 19 manner manner NN cord-297469-26d8o1xk 44 20 . . . cord-297469-26d8o1xk 45 1 The the DT cord-297469-26d8o1xk 45 2 results result NNS cord-297469-26d8o1xk 45 3 are be VBP cord-297469-26d8o1xk 45 4 presented present VBN cord-297469-26d8o1xk 45 5 as as IN cord-297469-26d8o1xk 45 6 a a DT cord-297469-26d8o1xk 45 7 percentage percentage NN cord-297469-26d8o1xk 45 8 of of IN cord-297469-26d8o1xk 45 9 the the DT cord-297469-26d8o1xk 45 10 untreated untreated JJ cord-297469-26d8o1xk 45 11 normal normal JJ cord-297469-26d8o1xk 45 12 group group NN cord-297469-26d8o1xk 45 13 . . . cord-297469-26d8o1xk 46 1 * * NFP cord-297469-26d8o1xk 46 2 p p XX cord-297469-26d8o1xk 46 3 < < XX cord-297469-26d8o1xk 46 4 0.05 0.05 CD cord-297469-26d8o1xk 46 5 was be VBD cord-297469-26d8o1xk 46 6 considered consider VBN cord-297469-26d8o1xk 46 7 to to TO cord-297469-26d8o1xk 46 8 be be VB cord-297469-26d8o1xk 46 9 significant significant JJ cord-297469-26d8o1xk 46 10 . . . cord-297469-26d8o1xk 47 1 Organelles Organelles NNP cord-297469-26d8o1xk 47 2 of of IN cord-297469-26d8o1xk 47 3 T. T. NNP cord-297469-26d8o1xk 47 4 gondii gondii NNP cord-297469-26d8o1xk 47 5 _SP cord-297469-26d8o1xk 48 1 T. T. NNP cord-297469-26d8o1xk 48 2 gondii gondii NNP cord-297469-26d8o1xk 48 3 causes cause VBZ cord-297469-26d8o1xk 48 4 unique unique JJ cord-297469-26d8o1xk 48 5 anti anti JJ cord-297469-26d8o1xk 48 6 - - JJ cord-297469-26d8o1xk 48 7 apoptotic apoptotic JJ cord-297469-26d8o1xk 48 8 features feature NNS cord-297469-26d8o1xk 48 9 and and CC cord-297469-26d8o1xk 48 10 parasitic parasitic JJ cord-297469-26d8o1xk 48 11 survival survival NN cord-297469-26d8o1xk 48 12 cycles cycle NNS cord-297469-26d8o1xk 48 13 or or CC cord-297469-26d8o1xk 48 14 stages stage NNS cord-297469-26d8o1xk 48 15 , , , cord-297469-26d8o1xk 48 16 such such JJ cord-297469-26d8o1xk 48 17 as as IN cord-297469-26d8o1xk 48 18 the the DT cord-297469-26d8o1xk 48 19 _SP cord-297469-26d8o1xk 48 20 inactivation inactivation NN cord-297469-26d8o1xk 48 21 of of IN cord-297469-26d8o1xk 48 22 apoptotic apoptotic JJ cord-297469-26d8o1xk 48 23 proteins protein NNS cord-297469-26d8o1xk 48 24 during during IN cord-297469-26d8o1xk 48 25 the the DT cord-297469-26d8o1xk 48 26 parasitic parasitic JJ cord-297469-26d8o1xk 48 27 life life NN cord-297469-26d8o1xk 48 28 - - HYPH cord-297469-26d8o1xk 48 29 cycle cycle NN cord-297469-26d8o1xk 48 30 in in IN cord-297469-26d8o1xk 48 31 host host NN cord-297469-26d8o1xk 48 32 cells cell NNS cord-297469-26d8o1xk 48 33 after after IN cord-297469-26d8o1xk 48 34 infection infection NN cord-297469-26d8o1xk 48 35 , , , cord-297469-26d8o1xk 48 36 showing show VBG cord-297469-26d8o1xk 48 37 _SP cord-297469-26d8o1xk 48 38 critical critical JJ cord-297469-26d8o1xk 48 39 roles role NNS cord-297469-26d8o1xk 48 40 during during IN cord-297469-26d8o1xk 48 41 the the DT cord-297469-26d8o1xk 48 42 proliferation proliferation NN cord-297469-26d8o1xk 48 43 and and CC cord-297469-26d8o1xk 48 44 survival survival NN cord-297469-26d8o1xk 48 45 of of IN cord-297469-26d8o1xk 48 46 T. t. NN cord-297469-26d8o1xk 48 47 gondii gondii NNP cord-297469-26d8o1xk 48 48 . . . cord-297469-26d8o1xk 49 1 In in IN cord-297469-26d8o1xk 49 2 particular particular JJ cord-297469-26d8o1xk 49 3 , , , cord-297469-26d8o1xk 49 4 the the DT cord-297469-26d8o1xk 49 5 PVM PVM NNP cord-297469-26d8o1xk 49 6 , , , cord-297469-26d8o1xk 49 7 that that WDT cord-297469-26d8o1xk 49 8 functions function VBZ cord-297469-26d8o1xk 49 9 as as IN cord-297469-26d8o1xk 49 10 a a DT cord-297469-26d8o1xk 49 11 critical critical JJ cord-297469-26d8o1xk 49 12 indicator indicator NN cord-297469-26d8o1xk 49 13 during during IN cord-297469-26d8o1xk 49 14 the the DT cord-297469-26d8o1xk 49 15 proliferation proliferation NN cord-297469-26d8o1xk 49 16 stage stage NN cord-297469-26d8o1xk 49 17 of of IN cord-297469-26d8o1xk 49 18 T. t. NN cord-297469-26d8o1xk 49 19 gondii gondii NN cord-297469-26d8o1xk 49 20 , , , cord-297469-26d8o1xk 49 21 is be VBZ cord-297469-26d8o1xk 49 22 activated activate VBN cord-297469-26d8o1xk 49 23 in in IN cord-297469-26d8o1xk 49 24 a a DT cord-297469-26d8o1xk 49 25 time time NN cord-297469-26d8o1xk 49 26 - - HYPH cord-297469-26d8o1xk 49 27 dependent dependent JJ cord-297469-26d8o1xk 49 28 manner manner NN cord-297469-26d8o1xk 49 29 after after IN cord-297469-26d8o1xk 49 30 cell cell NN cord-297469-26d8o1xk 49 31 invasion invasion NN cord-297469-26d8o1xk 49 32 of of IN cord-297469-26d8o1xk 49 33 T. t. NN cord-297469-26d8o1xk 49 34 gondii gondii NNP cord-297469-26d8o1xk 49 35 , , , cord-297469-26d8o1xk 49 36 which which WDT cord-297469-26d8o1xk 49 37 causes cause VBZ cord-297469-26d8o1xk 49 38 finally finally RB cord-297469-26d8o1xk 49 39 the the DT cord-297469-26d8o1xk 49 40 proliferation proliferation NN cord-297469-26d8o1xk 49 41 and and CC cord-297469-26d8o1xk 49 42 the the DT cord-297469-26d8o1xk 49 43 growth growth NN cord-297469-26d8o1xk 49 44 of of IN cord-297469-26d8o1xk 49 45 T. t. NN cord-297469-26d8o1xk 49 46 gondii gondii NNP cord-297469-26d8o1xk 49 47 . . . cord-297469-26d8o1xk 50 1 In in IN cord-297469-26d8o1xk 50 2 this this DT cord-297469-26d8o1xk 50 3 aspect aspect NN cord-297469-26d8o1xk 50 4 , , , cord-297469-26d8o1xk 50 5 we -PRON- PRP cord-297469-26d8o1xk 50 6 investigated investigate VBD cord-297469-26d8o1xk 50 7 the the DT cord-297469-26d8o1xk 50 8 inhibitory inhibitory JJ cord-297469-26d8o1xk 50 9 action action NN cord-297469-26d8o1xk 50 10 of of IN cord-297469-26d8o1xk 50 11 UA UA NNP cord-297469-26d8o1xk 50 12 against against IN cord-297469-26d8o1xk 50 13 subcellular subcellular JJ cord-297469-26d8o1xk 50 14 organelles organelle NNS cord-297469-26d8o1xk 50 15 such such JJ cord-297469-26d8o1xk 50 16 as as IN cord-297469-26d8o1xk 50 17 rhoptries rhoptrie NNS cord-297469-26d8o1xk 50 18 , , , cord-297469-26d8o1xk 50 19 micronemes micronemes NNP cord-297469-26d8o1xk 50 20 , , , cord-297469-26d8o1xk 50 21 and and CC cord-297469-26d8o1xk 50 22 inner inner JJ cord-297469-26d8o1xk 50 23 membrane membrane NN cord-297469-26d8o1xk 50 24 complex complex NN cord-297469-26d8o1xk 50 25 that that WDT cord-297469-26d8o1xk 50 26 form form VBP cord-297469-26d8o1xk 50 27 its -PRON- PRP$ cord-297469-26d8o1xk 50 28 intracellular intracellular JJ cord-297469-26d8o1xk 50 29 metabolic metabolic JJ cord-297469-26d8o1xk 50 30 network network NN cord-297469-26d8o1xk 50 31 as as RB cord-297469-26d8o1xk 50 32 well well RB cord-297469-26d8o1xk 50 33 as as IN cord-297469-26d8o1xk 50 34 the the DT cord-297469-26d8o1xk 50 35 homeostasis homeostasis NN cord-297469-26d8o1xk 50 36 of of IN cord-297469-26d8o1xk 50 37 T. t. NN cord-297469-26d8o1xk 50 38 gondii gondii NN cord-297469-26d8o1xk 50 39 . . . cord-297469-26d8o1xk 51 1 As as IN cord-297469-26d8o1xk 51 2 shown show VBN cord-297469-26d8o1xk 51 3 in in IN cord-297469-26d8o1xk 51 4 Figure Figure NNP cord-297469-26d8o1xk 51 5 3 3 CD cord-297469-26d8o1xk 51 6 , , , cord-297469-26d8o1xk 51 7 when when WRB cord-297469-26d8o1xk 51 8 T. T. NNP cord-297469-26d8o1xk 51 9 gondii gondii NNP cord-297469-26d8o1xk 51 10 was be VBD cord-297469-26d8o1xk 51 11 treated treat VBN cord-297469-26d8o1xk 51 12 with with IN cord-297469-26d8o1xk 51 13 different different JJ cord-297469-26d8o1xk 51 14 concentrations concentration NNS cord-297469-26d8o1xk 51 15 ( ( -LRB- cord-297469-26d8o1xk 51 16 50 50 CD cord-297469-26d8o1xk 51 17 and and CC cord-297469-26d8o1xk 51 18 100 100 CD cord-297469-26d8o1xk 51 19 μg μg NN cord-297469-26d8o1xk 51 20 / / SYM cord-297469-26d8o1xk 51 21 mL mL NNP cord-297469-26d8o1xk 51 22 ) ) -RRB- cord-297469-26d8o1xk 51 23 of of IN cord-297469-26d8o1xk 51 24 UA UA NNP cord-297469-26d8o1xk 51 25 and and CC cord-297469-26d8o1xk 51 26 SF SF NNP cord-297469-26d8o1xk 51 27 , , , cord-297469-26d8o1xk 51 28 respectively respectively RB cord-297469-26d8o1xk 51 29 , , , cord-297469-26d8o1xk 51 30 the the DT cord-297469-26d8o1xk 51 31 intracellular intracellular JJ cord-297469-26d8o1xk 51 32 organelles organelle NNS cord-297469-26d8o1xk 51 33 ( ( -LRB- cord-297469-26d8o1xk 51 34 rhoptry rhoptry NN cord-297469-26d8o1xk 51 35 protein protein NN cord-297469-26d8o1xk 51 36 18 18 CD cord-297469-26d8o1xk 51 37 ( ( -LRB- cord-297469-26d8o1xk 51 38 ROP ROP NNP cord-297469-26d8o1xk 51 39 18 18 CD cord-297469-26d8o1xk 51 40 ) ) -RRB- cord-297469-26d8o1xk 51 41 , , , cord-297469-26d8o1xk 51 42 microneme microneme NNP cord-297469-26d8o1xk 51 43 protein protein NNP cord-297469-26d8o1xk 51 44 8 8 CD cord-297469-26d8o1xk 51 45 ( ( -LRB- cord-297469-26d8o1xk 51 46 MIC MIC NNP cord-297469-26d8o1xk 51 47 8) 8) NN cord-297469-26d8o1xk 51 48 , , , cord-297469-26d8o1xk 51 49 and and CC cord-297469-26d8o1xk 51 50 inner inner JJ cord-297469-26d8o1xk 51 51 membrane membrane NN cord-297469-26d8o1xk 51 52 complex complex JJ cord-297469-26d8o1xk 51 53 sub sub JJ cord-297469-26d8o1xk 51 54 - - JJ cord-297469-26d8o1xk 51 55 compartment compartment JJ cord-297469-26d8o1xk 51 56 protein protein NN cord-297469-26d8o1xk 51 57 3 3 CD cord-297469-26d8o1xk 51 58 ( ( -LRB- cord-297469-26d8o1xk 51 59 IMC IMC NNP cord-297469-26d8o1xk 51 60 sub-3 sub-3 NNP cord-297469-26d8o1xk 51 61 ) ) -RRB- cord-297469-26d8o1xk 51 62 ) ) -RRB- cord-297469-26d8o1xk 51 63 of of IN cord-297469-26d8o1xk 51 64 T. t. NN cord-297469-26d8o1xk 51 65 gondii gondii NNP cord-297469-26d8o1xk 51 66 were be VBD cord-297469-26d8o1xk 51 67 markedly markedly RB cord-297469-26d8o1xk 51 68 decreased decrease VBN cord-297469-26d8o1xk 51 69 in in IN cord-297469-26d8o1xk 51 70 a a DT cord-297469-26d8o1xk 51 71 dose dose NN cord-297469-26d8o1xk 51 72 - - HYPH cord-297469-26d8o1xk 51 73 dependent dependent JJ cord-297469-26d8o1xk 51 74 manner manner NN cord-297469-26d8o1xk 51 75 , , , cord-297469-26d8o1xk 51 76 and and CC cord-297469-26d8o1xk 51 77 their -PRON- PRP$ cord-297469-26d8o1xk 51 78 changes change NNS cord-297469-26d8o1xk 51 79 were be VBD cord-297469-26d8o1xk 51 80 clearly clearly RB cord-297469-26d8o1xk 51 81 observed observe VBN cord-297469-26d8o1xk 51 82 under under IN cord-297469-26d8o1xk 51 83 electrophoresis electrophoresis NN cord-297469-26d8o1xk 51 84 . . . cord-297469-26d8o1xk 52 1 In in IN cord-297469-26d8o1xk 52 2 particular particular JJ cord-297469-26d8o1xk 52 3 , , , cord-297469-26d8o1xk 52 4 it -PRON- PRP cord-297469-26d8o1xk 52 5 is be VBZ cord-297469-26d8o1xk 52 6 known know VBN cord-297469-26d8o1xk 52 7 that that IN cord-297469-26d8o1xk 52 8 rhoptry rhoptry NN cord-297469-26d8o1xk 52 9 plays play VBZ cord-297469-26d8o1xk 52 10 as as IN cord-297469-26d8o1xk 52 11 a a DT cord-297469-26d8o1xk 52 12 critical critical JJ cord-297469-26d8o1xk 52 13 factor factor NN cord-297469-26d8o1xk 52 14 when when WRB cord-297469-26d8o1xk 52 15 T. T. NNP cord-297469-26d8o1xk 52 16 gondii gondii NNP cord-297469-26d8o1xk 52 17 enters enter VBZ cord-297469-26d8o1xk 52 18 into into IN cord-297469-26d8o1xk 52 19 host host NN cord-297469-26d8o1xk 52 20 cells cell NNS cord-297469-26d8o1xk 52 21 during during IN cord-297469-26d8o1xk 52 22 invasion invasion NN cord-297469-26d8o1xk 52 23 stage stage NN cord-297469-26d8o1xk 52 24 [ [ -LRB- cord-297469-26d8o1xk 52 25 44 44 CD cord-297469-26d8o1xk 52 26 ] ] -RRB- cord-297469-26d8o1xk 52 27 [ [ -LRB- cord-297469-26d8o1xk 52 28 45 45 CD cord-297469-26d8o1xk 52 29 ] ] -RRB- cord-297469-26d8o1xk 53 1 [ [ -LRB- cord-297469-26d8o1xk 53 2 46 46 CD cord-297469-26d8o1xk 53 3 ] ] -RRB- cord-297469-26d8o1xk 53 4 [ [ -LRB- cord-297469-26d8o1xk 53 5 47 47 CD cord-297469-26d8o1xk 53 6 ] ] -RRB- cord-297469-26d8o1xk 53 7 [ [ -LRB- cord-297469-26d8o1xk 53 8 48 48 CD cord-297469-26d8o1xk 53 9 ] ] -RRB- cord-297469-26d8o1xk 53 10 . . . cord-297469-26d8o1xk 54 1 In in IN cord-297469-26d8o1xk 54 2 these these DT cord-297469-26d8o1xk 54 3 aspects aspect NNS cord-297469-26d8o1xk 54 4 , , , cord-297469-26d8o1xk 54 5 this this DT cord-297469-26d8o1xk 54 6 result result NN cord-297469-26d8o1xk 54 7 shows show VBZ cord-297469-26d8o1xk 54 8 clearly clearly RB cord-297469-26d8o1xk 54 9 that that IN cord-297469-26d8o1xk 54 10 UA UA NNP cord-297469-26d8o1xk 54 11 not not RB cord-297469-26d8o1xk 54 12 only only RB cord-297469-26d8o1xk 54 13 has have VBZ cord-297469-26d8o1xk 54 14 the the DT cord-297469-26d8o1xk 54 15 direct direct JJ cord-297469-26d8o1xk 54 16 inhibitory inhibitory JJ cord-297469-26d8o1xk 54 17 effect effect NN cord-297469-26d8o1xk 54 18 against against IN cord-297469-26d8o1xk 54 19 the the DT cord-297469-26d8o1xk 54 20 survival survival NN cord-297469-26d8o1xk 54 21 of of IN cord-297469-26d8o1xk 54 22 T. t. NN cord-297469-26d8o1xk 54 23 gondii gondii NN cord-297469-26d8o1xk 54 24 but but CC cord-297469-26d8o1xk 54 25 also also RB cord-297469-26d8o1xk 54 26 induces induce VBZ cord-297469-26d8o1xk 54 27 the the DT cord-297469-26d8o1xk 54 28 anti anti JJ cord-297469-26d8o1xk 54 29 - - JJ cord-297469-26d8o1xk 54 30 T. t. JJ cord-297469-26d8o1xk 54 31 gondii gondii NN cord-297469-26d8o1xk 54 32 effect effect NN cord-297469-26d8o1xk 54 33 by by IN cord-297469-26d8o1xk 54 34 strongly strongly RB cord-297469-26d8o1xk 54 35 blocking block VBG cord-297469-26d8o1xk 54 36 or or CC cord-297469-26d8o1xk 54 37 inhibiting inhibit VBG cord-297469-26d8o1xk 54 38 the the DT cord-297469-26d8o1xk 54 39 homeostasis homeostasis NN cord-297469-26d8o1xk 54 40 and and CC cord-297469-26d8o1xk 54 41 network network NN cord-297469-26d8o1xk 54 42 structure structure NN cord-297469-26d8o1xk 54 43 of of IN cord-297469-26d8o1xk 54 44 the the DT cord-297469-26d8o1xk 54 45 intracellular intracellular JJ cord-297469-26d8o1xk 54 46 organelles organelle NNS cord-297469-26d8o1xk 54 47 of of IN cord-297469-26d8o1xk 54 48 T. t. NN cord-297469-26d8o1xk 54 49 gondii gondii NN cord-297469-26d8o1xk 54 50 . . . cord-297469-26d8o1xk 55 1 Therefore therefore RB cord-297469-26d8o1xk 55 2 , , , cord-297469-26d8o1xk 55 3 these these DT cord-297469-26d8o1xk 55 4 results result NNS cord-297469-26d8o1xk 55 5 demonstrate demonstrate VBP cord-297469-26d8o1xk 55 6 substantial substantial JJ cord-297469-26d8o1xk 55 7 evidence evidence NN cord-297469-26d8o1xk 55 8 that that IN cord-297469-26d8o1xk 55 9 UA UA NNP cord-297469-26d8o1xk 55 10 consistently consistently RB cord-297469-26d8o1xk 55 11 causes cause VBZ cord-297469-26d8o1xk 55 12 anti anti JJ cord-297469-26d8o1xk 55 13 - - JJ cord-297469-26d8o1xk 55 14 T. t. JJ cord-297469-26d8o1xk 55 15 gondii gondii NN cord-297469-26d8o1xk 55 16 activity activity NN cord-297469-26d8o1xk 55 17 / / SYM cord-297469-26d8o1xk 55 18 action action NN cord-297469-26d8o1xk 55 19 by by IN cord-297469-26d8o1xk 55 20 effectively effectively RB cord-297469-26d8o1xk 55 21 inhibiting inhibit VBG cord-297469-26d8o1xk 55 22 the the DT cord-297469-26d8o1xk 55 23 intracellular intracellular JJ cord-297469-26d8o1xk 55 24 organelles organelle NNS cord-297469-26d8o1xk 55 25 of of IN cord-297469-26d8o1xk 55 26 T. t. NN cord-297469-26d8o1xk 55 27 gondii gondii NN cord-297469-26d8o1xk 55 28 . . . cord-297469-26d8o1xk 56 1 We -PRON- PRP cord-297469-26d8o1xk 56 2 evaluated evaluate VBD cord-297469-26d8o1xk 56 3 the the DT cord-297469-26d8o1xk 56 4 effect effect NN cord-297469-26d8o1xk 56 5 of of IN cord-297469-26d8o1xk 56 6 ROS ROS NNP cord-297469-26d8o1xk 56 7 and and CC cord-297469-26d8o1xk 56 8 NO no DT cord-297469-26d8o1xk 56 9 production production NN cord-297469-26d8o1xk 56 10 induced induce VBN cord-297469-26d8o1xk 56 11 by by IN cord-297469-26d8o1xk 56 12 ursolic ursolic JJ cord-297469-26d8o1xk 56 13 acid acid NN cord-297469-26d8o1xk 56 14 in in IN cord-297469-26d8o1xk 56 15 immune immune JJ cord-297469-26d8o1xk 56 16 cells cell NNS cord-297469-26d8o1xk 56 17 infected infect VBN cord-297469-26d8o1xk 56 18 with with IN cord-297469-26d8o1xk 56 19 T. t. NN cord-297469-26d8o1xk 56 20 gondii gondii NNP cord-297469-26d8o1xk 56 21 . . . cord-297469-26d8o1xk 57 1 The the DT cord-297469-26d8o1xk 57 2 production production NN cord-297469-26d8o1xk 57 3 of of IN cord-297469-26d8o1xk 57 4 NO no NN cord-297469-26d8o1xk 57 5 and and CC cord-297469-26d8o1xk 57 6 ROS ROS NNP cord-297469-26d8o1xk 57 7 was be VBD cord-297469-26d8o1xk 57 8 measured measure VBN cord-297469-26d8o1xk 57 9 in in IN cord-297469-26d8o1xk 57 10 a a DT cord-297469-26d8o1xk 57 11 dose dose NN cord-297469-26d8o1xk 57 12 - - HYPH cord-297469-26d8o1xk 57 13 dependent dependent JJ cord-297469-26d8o1xk 57 14 manner manner NN cord-297469-26d8o1xk 57 15 when when WRB cord-297469-26d8o1xk 57 16 T. T. NNP cord-297469-26d8o1xk 57 17 gondii gondii NNP cord-297469-26d8o1xk 57 18 - - HYPH cord-297469-26d8o1xk 57 19 infected infect VBN cord-297469-26d8o1xk 57 20 co co JJ cord-297469-26d8o1xk 57 21 - - JJ cord-297469-26d8o1xk 57 22 cultured cultured JJ cord-297469-26d8o1xk 57 23 immune immune JJ cord-297469-26d8o1xk 57 24 cells cell NNS cord-297469-26d8o1xk 57 25 were be VBD cord-297469-26d8o1xk 57 26 incubated incubate VBN cord-297469-26d8o1xk 57 27 with with IN cord-297469-26d8o1xk 57 28 various various JJ cord-297469-26d8o1xk 57 29 concentrations concentration NNS cord-297469-26d8o1xk 57 30 ( ( -LRB- cord-297469-26d8o1xk 57 31 25 25 CD cord-297469-26d8o1xk 57 32 - - SYM cord-297469-26d8o1xk 57 33 100 100 CD cord-297469-26d8o1xk 57 34 µg µg NN cord-297469-26d8o1xk 57 35 / / SYM cord-297469-26d8o1xk 57 36 mL ml NN cord-297469-26d8o1xk 57 37 ) ) -RRB- cord-297469-26d8o1xk 57 38 of of IN cord-297469-26d8o1xk 57 39 UA UA NNP cord-297469-26d8o1xk 57 40 and and CC cord-297469-26d8o1xk 57 41 SF SF NNP cord-297469-26d8o1xk 57 42 for for IN cord-297469-26d8o1xk 57 43 24 24 CD cord-297469-26d8o1xk 57 44 h h NNP cord-297469-26d8o1xk 57 45 , , , cord-297469-26d8o1xk 57 46 respectively respectively RB cord-297469-26d8o1xk 57 47 . . . cord-297469-26d8o1xk 58 1 In in IN cord-297469-26d8o1xk 58 2 particular particular JJ cord-297469-26d8o1xk 58 3 , , , cord-297469-26d8o1xk 58 4 the the DT cord-297469-26d8o1xk 58 5 production production NN cord-297469-26d8o1xk 58 6 of of IN cord-297469-26d8o1xk 58 7 ROS ROS NNP cord-297469-26d8o1xk 58 8 was be VBD cord-297469-26d8o1xk 58 9 increased increase VBN cord-297469-26d8o1xk 58 10 in in IN cord-297469-26d8o1xk 58 11 the the DT cord-297469-26d8o1xk 58 12 T. T. NNP cord-297469-26d8o1xk 58 13 gondii gondii NN cord-297469-26d8o1xk 58 14 - - HYPH cord-297469-26d8o1xk 58 15 infected infect VBN cord-297469-26d8o1xk 58 16 group group NN cord-297469-26d8o1xk 58 17 treated treat VBN cord-297469-26d8o1xk 58 18 with with IN cord-297469-26d8o1xk 58 19 UA UA NNP cord-297469-26d8o1xk 58 20 compared compare VBN cord-297469-26d8o1xk 58 21 with with IN cord-297469-26d8o1xk 58 22 T. T. NNP cord-297469-26d8o1xk 58 23 gondii gondii NN cord-297469-26d8o1xk 58 24 - - HYPH cord-297469-26d8o1xk 58 25 infected infect VBN cord-297469-26d8o1xk 58 26 group group NN cord-297469-26d8o1xk 58 27 . . . cord-297469-26d8o1xk 59 1 However however RB cord-297469-26d8o1xk 59 2 , , , cord-297469-26d8o1xk 59 3 in in IN cord-297469-26d8o1xk 59 4 100 100 CD cord-297469-26d8o1xk 59 5 µg µg NN cord-297469-26d8o1xk 59 6 / / SYM cord-297469-26d8o1xk 59 7 mL ml NN cord-297469-26d8o1xk 59 8 of of IN cord-297469-26d8o1xk 59 9 UA UA NNP cord-297469-26d8o1xk 59 10 , , , cord-297469-26d8o1xk 59 11 ROS ROS NNP cord-297469-26d8o1xk 59 12 activity activity NN cord-297469-26d8o1xk 59 13 gradually gradually RB cord-297469-26d8o1xk 59 14 indicated indicate VBD cord-297469-26d8o1xk 59 15 lower low JJR cord-297469-26d8o1xk 59 16 concentrations concentration NNS cord-297469-26d8o1xk 59 17 than than IN cord-297469-26d8o1xk 59 18 other other JJ cord-297469-26d8o1xk 59 19 UA UA NNP cord-297469-26d8o1xk 59 20 - - HYPH cord-297469-26d8o1xk 59 21 treated treat VBN cord-297469-26d8o1xk 59 22 groups group NNS cord-297469-26d8o1xk 59 23 ( ( -LRB- cord-297469-26d8o1xk 59 24 Figure Figure NNP cord-297469-26d8o1xk 59 25 4 4 CD cord-297469-26d8o1xk 59 26 ) ) -RRB- cord-297469-26d8o1xk 59 27 , , , cord-297469-26d8o1xk 59 28 and and CC cord-297469-26d8o1xk 59 29 these these DT cord-297469-26d8o1xk 59 30 changes change NNS cord-297469-26d8o1xk 59 31 of of IN cord-297469-26d8o1xk 59 32 ROS ROS NNP cord-297469-26d8o1xk 59 33 activity activity NN cord-297469-26d8o1xk 59 34 show show VBP cord-297469-26d8o1xk 59 35 that that IN cord-297469-26d8o1xk 59 36 UA UA NNP cord-297469-26d8o1xk 59 37 acts act VBZ cord-297469-26d8o1xk 59 38 as as IN cord-297469-26d8o1xk 59 39 a a DT cord-297469-26d8o1xk 59 40 modulator modulator NN cord-297469-26d8o1xk 59 41 which which WDT cord-297469-26d8o1xk 59 42 consistently consistently RB cord-297469-26d8o1xk 59 43 inhibits inhibit VBZ cord-297469-26d8o1xk 59 44 the the DT cord-297469-26d8o1xk 59 45 proliferation proliferation NN cord-297469-26d8o1xk 59 46 and and CC cord-297469-26d8o1xk 59 47 the the DT cord-297469-26d8o1xk 59 48 growth growth NN cord-297469-26d8o1xk 59 49 of of IN cord-297469-26d8o1xk 59 50 T. t. NN cord-297469-26d8o1xk 59 51 gondii gondii NN cord-297469-26d8o1xk 59 52 by by IN cord-297469-26d8o1xk 59 53 promoting promote VBG cord-297469-26d8o1xk 59 54 the the DT cord-297469-26d8o1xk 59 55 production production NN cord-297469-26d8o1xk 59 56 of of IN cord-297469-26d8o1xk 59 57 ROS ROS NNP cord-297469-26d8o1xk 59 58 in in IN cord-297469-26d8o1xk 59 59 immune immune JJ cord-297469-26d8o1xk 59 60 cells cell NNS cord-297469-26d8o1xk 59 61 after after IN cord-297469-26d8o1xk 59 62 the the DT cord-297469-26d8o1xk 59 63 parasite parasite NN cord-297469-26d8o1xk 59 64 infection infection NN cord-297469-26d8o1xk 59 65 . . . cord-297469-26d8o1xk 60 1 Even even RB cord-297469-26d8o1xk 60 2 though though IN cord-297469-26d8o1xk 60 3 SF SF NNP cord-297469-26d8o1xk 60 4 - - HYPH cord-297469-26d8o1xk 60 5 treated treat VBN cord-297469-26d8o1xk 60 6 groups group NNS cord-297469-26d8o1xk 60 7 significantly significantly RB cord-297469-26d8o1xk 60 8 increased increase VBD cord-297469-26d8o1xk 60 9 ROS ROS NNP cord-297469-26d8o1xk 60 10 production production NN cord-297469-26d8o1xk 60 11 compared compare VBN cord-297469-26d8o1xk 60 12 to to IN cord-297469-26d8o1xk 60 13 the the DT cord-297469-26d8o1xk 60 14 T. T. NNP cord-297469-26d8o1xk 60 15 gondii gondii NN cord-297469-26d8o1xk 60 16 - - HYPH cord-297469-26d8o1xk 60 17 infected infect VBN cord-297469-26d8o1xk 60 18 group group NN cord-297469-26d8o1xk 60 19 , , , cord-297469-26d8o1xk 60 20 there there EX cord-297469-26d8o1xk 60 21 were be VBD cord-297469-26d8o1xk 60 22 low low JJ cord-297469-26d8o1xk 60 23 ROS ROS NNP cord-297469-26d8o1xk 60 24 - - HYPH cord-297469-26d8o1xk 60 25 productive productive JJ cord-297469-26d8o1xk 60 26 rates rate NNS cord-297469-26d8o1xk 60 27 compared compare VBN cord-297469-26d8o1xk 60 28 to to IN cord-297469-26d8o1xk 60 29 UA UA NNP cord-297469-26d8o1xk 60 30 - - HYPH cord-297469-26d8o1xk 60 31 treated treat VBN cord-297469-26d8o1xk 60 32 groups group NNS cord-297469-26d8o1xk 60 33 . . . cord-297469-26d8o1xk 61 1 Furthermore furthermore RB cord-297469-26d8o1xk 61 2 , , , cord-297469-26d8o1xk 61 3 the the DT cord-297469-26d8o1xk 61 4 rate rate NN cord-297469-26d8o1xk 61 5 of of IN cord-297469-26d8o1xk 61 6 NO no DT cord-297469-26d8o1xk 61 7 production production NN cord-297469-26d8o1xk 61 8 was be VBD cord-297469-26d8o1xk 61 9 strongly strongly RB cord-297469-26d8o1xk 61 10 increased increase VBN cord-297469-26d8o1xk 61 11 in in IN cord-297469-26d8o1xk 61 12 T. T. NNP cord-297469-26d8o1xk 61 13 gondii gondii NNP cord-297469-26d8o1xk 61 14 - - HYPH cord-297469-26d8o1xk 61 15 infected infect VBN cord-297469-26d8o1xk 61 16 group group NN cord-297469-26d8o1xk 61 17 treated treat VBN cord-297469-26d8o1xk 61 18 with with IN cord-297469-26d8o1xk 61 19 UA UA NNP cord-297469-26d8o1xk 61 20 compared compare VBN cord-297469-26d8o1xk 61 21 with with IN cord-297469-26d8o1xk 61 22 normal normal JJ cord-297469-26d8o1xk 61 23 and and CC cord-297469-26d8o1xk 61 24 T. t. NN cord-297469-26d8o1xk 61 25 gondii gondii NN cord-297469-26d8o1xk 61 26 - - HYPH cord-297469-26d8o1xk 61 27 infected infect VBN cord-297469-26d8o1xk 61 28 groups group NNS cord-297469-26d8o1xk 61 29 , , , cord-297469-26d8o1xk 61 30 but but CC cord-297469-26d8o1xk 61 31 in in IN cord-297469-26d8o1xk 61 32 the the DT cord-297469-26d8o1xk 61 33 range range NN cord-297469-26d8o1xk 61 34 of of IN cord-297469-26d8o1xk 61 35 100 100 CD cord-297469-26d8o1xk 61 36 µg µg NN cord-297469-26d8o1xk 61 37 / / SYM cord-297469-26d8o1xk 61 38 mL ml NN cord-297469-26d8o1xk 61 39 of of IN cord-297469-26d8o1xk 61 40 UA UA NNP cord-297469-26d8o1xk 61 41 , , , cord-297469-26d8o1xk 61 42 the the DT cord-297469-26d8o1xk 61 43 rate rate NN cord-297469-26d8o1xk 61 44 of of IN cord-297469-26d8o1xk 61 45 NO no DT cord-297469-26d8o1xk 61 46 production production NN cord-297469-26d8o1xk 61 47 were be VBD cord-297469-26d8o1xk 61 48 low low JJ cord-297469-26d8o1xk 61 49 concentrations concentration NNS cord-297469-26d8o1xk 61 50 compared compare VBN cord-297469-26d8o1xk 61 51 with with IN cord-297469-26d8o1xk 61 52 other other JJ cord-297469-26d8o1xk 61 53 UA UA NNP cord-297469-26d8o1xk 61 54 - - HYPH cord-297469-26d8o1xk 61 55 treated treat VBN cord-297469-26d8o1xk 61 56 groups group NNS cord-297469-26d8o1xk 61 57 ( ( -LRB- cord-297469-26d8o1xk 61 58 Figure figure NN cord-297469-26d8o1xk 61 59 5 5 CD cord-297469-26d8o1xk 61 60 ) ) -RRB- cord-297469-26d8o1xk 61 61 . . . cord-297469-26d8o1xk 62 1 However however RB cord-297469-26d8o1xk 62 2 , , , cord-297469-26d8o1xk 62 3 the the DT cord-297469-26d8o1xk 62 4 activities activity NNS cord-297469-26d8o1xk 62 5 of of IN cord-297469-26d8o1xk 62 6 both both CC cord-297469-26d8o1xk 62 7 ROS ROS NNP cord-297469-26d8o1xk 62 8 and and CC cord-297469-26d8o1xk 62 9 NO no DT cord-297469-26d8o1xk 62 10 induced induce VBN cord-297469-26d8o1xk 62 11 by by IN cord-297469-26d8o1xk 62 12 UA UA NNP cord-297469-26d8o1xk 62 13 were be VBD cord-297469-26d8o1xk 62 14 significantly significantly RB cord-297469-26d8o1xk 62 15 increased increase VBN cord-297469-26d8o1xk 62 16 more more RBR cord-297469-26d8o1xk 62 17 than than IN cord-297469-26d8o1xk 62 18 normal normal JJ cord-297469-26d8o1xk 62 19 and and CC cord-297469-26d8o1xk 62 20 infection infection NN cord-297469-26d8o1xk 62 21 groups group NNS cord-297469-26d8o1xk 62 22 . . . cord-297469-26d8o1xk 63 1 Interestingly interestingly RB cord-297469-26d8o1xk 63 2 , , , cord-297469-26d8o1xk 63 3 the the DT cord-297469-26d8o1xk 63 4 activities activity NNS cord-297469-26d8o1xk 63 5 of of IN cord-297469-26d8o1xk 63 6 ROS ROS NNP cord-297469-26d8o1xk 63 7 and and CC cord-297469-26d8o1xk 63 8 NO no UH cord-297469-26d8o1xk 63 9 in in IN cord-297469-26d8o1xk 63 10 T. t. NN cord-297469-26d8o1xk 63 11 gondii gondii NN cord-297469-26d8o1xk 63 12 - - HYPH cord-297469-26d8o1xk 63 13 infected infect VBN cord-297469-26d8o1xk 63 14 cells cell NNS cord-297469-26d8o1xk 63 15 treated treat VBN cord-297469-26d8o1xk 63 16 with with IN cord-297469-26d8o1xk 63 17 SF SF NNP cord-297469-26d8o1xk 63 18 were be VBD cord-297469-26d8o1xk 63 19 lower low JJR cord-297469-26d8o1xk 63 20 than than IN cord-297469-26d8o1xk 63 21 T. T. NNP cord-297469-26d8o1xk 63 22 gondii gondii NN cord-297469-26d8o1xk 63 23 - - HYPH cord-297469-26d8o1xk 63 24 infected infect VBN cord-297469-26d8o1xk 63 25 groups group NNS cord-297469-26d8o1xk 63 26 treated treat VBN cord-297469-26d8o1xk 63 27 with with IN cord-297469-26d8o1xk 63 28 UA UA NNP cord-297469-26d8o1xk 63 29 . . . cord-297469-26d8o1xk 64 1 The the DT cord-297469-26d8o1xk 64 2 activities activity NNS cord-297469-26d8o1xk 64 3 of of IN cord-297469-26d8o1xk 64 4 ROS ROS NNP cord-297469-26d8o1xk 64 5 and and CC cord-297469-26d8o1xk 64 6 NO no DT cord-297469-26d8o1xk 64 7 were be VBD cord-297469-26d8o1xk 64 8 significantly significantly RB cord-297469-26d8o1xk 64 9 increased increase VBN cord-297469-26d8o1xk 64 10 in in IN cord-297469-26d8o1xk 64 11 T. T. NNP cord-297469-26d8o1xk 64 12 gondii gondii NN cord-297469-26d8o1xk 64 13 - - HYPH cord-297469-26d8o1xk 64 14 infected infect VBN cord-297469-26d8o1xk 64 15 groups group NNS cord-297469-26d8o1xk 64 16 treated treat VBN cord-297469-26d8o1xk 64 17 with with IN cord-297469-26d8o1xk 64 18 UA UA NNP cord-297469-26d8o1xk 64 19 and and CC cord-297469-26d8o1xk 64 20 SF SF NNP cord-297469-26d8o1xk 64 21 , , , cord-297469-26d8o1xk 64 22 respectively respectively RB cord-297469-26d8o1xk 64 23 , , , cord-297469-26d8o1xk 64 24 whereas whereas IN cord-297469-26d8o1xk 64 25 their -PRON- PRP$ cord-297469-26d8o1xk 64 26 activities activity NNS cord-297469-26d8o1xk 64 27 were be VBD cord-297469-26d8o1xk 64 28 gradually gradually RB cord-297469-26d8o1xk 64 29 reduced reduce VBN cord-297469-26d8o1xk 64 30 in in IN cord-297469-26d8o1xk 64 31 high high JJ cord-297469-26d8o1xk 64 32 concentrations concentration NNS cord-297469-26d8o1xk 64 33 . . . cord-297469-26d8o1xk 65 1 These these DT cord-297469-26d8o1xk 65 2 results result NNS cord-297469-26d8o1xk 65 3 show show VBP cord-297469-26d8o1xk 65 4 that that IN cord-297469-26d8o1xk 65 5 UA UA NNP cord-297469-26d8o1xk 65 6 not not RB cord-297469-26d8o1xk 65 7 only only RB cord-297469-26d8o1xk 65 8 consistently consistently RB cord-297469-26d8o1xk 65 9 induces induce VBZ cord-297469-26d8o1xk 65 10 the the DT cord-297469-26d8o1xk 65 11 production production NN cord-297469-26d8o1xk 65 12 of of IN cord-297469-26d8o1xk 65 13 ROS ROS NNP cord-297469-26d8o1xk 65 14 and and CC cord-297469-26d8o1xk 65 15 NO no UH cord-297469-26d8o1xk 65 16 through through IN cord-297469-26d8o1xk 65 17 the the DT cord-297469-26d8o1xk 65 18 interaction interaction NN cord-297469-26d8o1xk 65 19 between between IN cord-297469-26d8o1xk 65 20 it -PRON- PRP cord-297469-26d8o1xk 65 21 and and CC cord-297469-26d8o1xk 65 22 immune immune JJ cord-297469-26d8o1xk 65 23 cells cell NNS cord-297469-26d8o1xk 65 24 in in IN cord-297469-26d8o1xk 65 25 T. T. NNP cord-297469-26d8o1xk 65 26 gondii gondii NN cord-297469-26d8o1xk 65 27 - - HYPH cord-297469-26d8o1xk 65 28 infected infect VBN cord-297469-26d8o1xk 65 29 immune immune JJ cord-297469-26d8o1xk 65 30 cells cell NNS cord-297469-26d8o1xk 65 31 , , , cord-297469-26d8o1xk 65 32 but but CC cord-297469-26d8o1xk 65 33 may may MD cord-297469-26d8o1xk 65 34 also also RB cord-297469-26d8o1xk 65 35 be be VB cord-297469-26d8o1xk 65 36 used use VBN cord-297469-26d8o1xk 65 37 as as IN cord-297469-26d8o1xk 65 38 a a DT cord-297469-26d8o1xk 65 39 synergic synergic JJ cord-297469-26d8o1xk 65 40 compound compound NN cord-297469-26d8o1xk 65 41 for for IN cord-297469-26d8o1xk 65 42 the the DT cord-297469-26d8o1xk 65 43 immunomodulation immunomodulation NN cord-297469-26d8o1xk 65 44 after after IN cord-297469-26d8o1xk 65 45 parasitic parasitic JJ cord-297469-26d8o1xk 65 46 infection infection NN cord-297469-26d8o1xk 65 47 . . . cord-297469-26d8o1xk 66 1 We -PRON- PRP cord-297469-26d8o1xk 66 2 evaluated evaluate VBD cord-297469-26d8o1xk 66 3 the the DT cord-297469-26d8o1xk 66 4 effect effect NN cord-297469-26d8o1xk 66 5 of of IN cord-297469-26d8o1xk 66 6 ROS ROS NNP cord-297469-26d8o1xk 66 7 and and CC cord-297469-26d8o1xk 66 8 NO no DT cord-297469-26d8o1xk 66 9 production production NN cord-297469-26d8o1xk 66 10 induced induce VBN cord-297469-26d8o1xk 66 11 by by IN cord-297469-26d8o1xk 66 12 ursolic ursolic JJ cord-297469-26d8o1xk 66 13 acid acid NN cord-297469-26d8o1xk 66 14 in in IN cord-297469-26d8o1xk 66 15 immune immune JJ cord-297469-26d8o1xk 66 16 cells cell NNS cord-297469-26d8o1xk 66 17 infected infect VBN cord-297469-26d8o1xk 66 18 with with IN cord-297469-26d8o1xk 66 19 T. t. NN cord-297469-26d8o1xk 66 20 gondii gondii NNP cord-297469-26d8o1xk 66 21 . . . cord-297469-26d8o1xk 67 1 The the DT cord-297469-26d8o1xk 67 2 production production NN cord-297469-26d8o1xk 67 3 of of IN cord-297469-26d8o1xk 67 4 NO no NN cord-297469-26d8o1xk 67 5 and and CC cord-297469-26d8o1xk 67 6 ROS ROS NNP cord-297469-26d8o1xk 67 7 was be VBD cord-297469-26d8o1xk 67 8 measured measure VBN cord-297469-26d8o1xk 67 9 in in IN cord-297469-26d8o1xk 67 10 a a DT cord-297469-26d8o1xk 67 11 dose dose NN cord-297469-26d8o1xk 67 12 - - HYPH cord-297469-26d8o1xk 67 13 dependent dependent JJ cord-297469-26d8o1xk 67 14 manner manner NN cord-297469-26d8o1xk 67 15 when when WRB cord-297469-26d8o1xk 67 16 T. T. NNP cord-297469-26d8o1xk 67 17 gondii gondii NNP cord-297469-26d8o1xk 67 18 - - HYPH cord-297469-26d8o1xk 67 19 infected infect VBN cord-297469-26d8o1xk 67 20 co co JJ cord-297469-26d8o1xk 67 21 - - JJ cord-297469-26d8o1xk 67 22 cultured cultured JJ cord-297469-26d8o1xk 67 23 immune immune JJ cord-297469-26d8o1xk 67 24 cells cell NNS cord-297469-26d8o1xk 67 25 were be VBD cord-297469-26d8o1xk 67 26 incubated incubate VBN cord-297469-26d8o1xk 67 27 with with IN cord-297469-26d8o1xk 67 28 various various JJ cord-297469-26d8o1xk 67 29 concentrations concentration NNS cord-297469-26d8o1xk 67 30 ( ( -LRB- cord-297469-26d8o1xk 67 31 25 25 CD cord-297469-26d8o1xk 67 32 - - SYM cord-297469-26d8o1xk 67 33 100 100 CD cord-297469-26d8o1xk 67 34 μg μg NNP cord-297469-26d8o1xk 67 35 / / SYM cord-297469-26d8o1xk 67 36 mL mL NNP cord-297469-26d8o1xk 67 37 ) ) -RRB- cord-297469-26d8o1xk 67 38 of of IN cord-297469-26d8o1xk 67 39 UA UA NNP cord-297469-26d8o1xk 67 40 and and CC cord-297469-26d8o1xk 67 41 SF SF NNP cord-297469-26d8o1xk 67 42 for for IN cord-297469-26d8o1xk 67 43 24 24 CD cord-297469-26d8o1xk 67 44 h h NNP cord-297469-26d8o1xk 67 45 , , , cord-297469-26d8o1xk 67 46 respectively respectively RB cord-297469-26d8o1xk 67 47 . . . cord-297469-26d8o1xk 68 1 In in IN cord-297469-26d8o1xk 68 2 particular particular JJ cord-297469-26d8o1xk 68 3 , , , cord-297469-26d8o1xk 68 4 the the DT cord-297469-26d8o1xk 68 5 production production NN cord-297469-26d8o1xk 68 6 of of IN cord-297469-26d8o1xk 68 7 ROS ROS NNP cord-297469-26d8o1xk 68 8 was be VBD cord-297469-26d8o1xk 68 9 increased increase VBN cord-297469-26d8o1xk 68 10 in in IN cord-297469-26d8o1xk 68 11 the the DT cord-297469-26d8o1xk 68 12 T. T. NNP cord-297469-26d8o1xk 68 13 gondii gondii NN cord-297469-26d8o1xk 68 14 - - HYPH cord-297469-26d8o1xk 68 15 infected infect VBN cord-297469-26d8o1xk 68 16 group group NN cord-297469-26d8o1xk 68 17 treated treat VBN cord-297469-26d8o1xk 68 18 with with IN cord-297469-26d8o1xk 68 19 UA UA NNP cord-297469-26d8o1xk 68 20 compared compare VBN cord-297469-26d8o1xk 68 21 with with IN cord-297469-26d8o1xk 68 22 T. T. NNP cord-297469-26d8o1xk 68 23 gondii gondii NN cord-297469-26d8o1xk 68 24 - - HYPH cord-297469-26d8o1xk 68 25 infected infect VBN cord-297469-26d8o1xk 68 26 group group NN cord-297469-26d8o1xk 68 27 . . . cord-297469-26d8o1xk 69 1 However however RB cord-297469-26d8o1xk 69 2 , , , cord-297469-26d8o1xk 69 3 in in IN cord-297469-26d8o1xk 69 4 100 100 CD cord-297469-26d8o1xk 69 5 μg μg NN cord-297469-26d8o1xk 69 6 / / SYM cord-297469-26d8o1xk 69 7 mL mL NNP cord-297469-26d8o1xk 69 8 of of IN cord-297469-26d8o1xk 69 9 UA UA NNP cord-297469-26d8o1xk 69 10 , , , cord-297469-26d8o1xk 69 11 ROS ROS NNP cord-297469-26d8o1xk 69 12 activity activity NN cord-297469-26d8o1xk 69 13 gradually gradually RB cord-297469-26d8o1xk 69 14 indicated indicate VBD cord-297469-26d8o1xk 69 15 lower low JJR cord-297469-26d8o1xk 69 16 concentrations concentration NNS cord-297469-26d8o1xk 69 17 than than IN cord-297469-26d8o1xk 69 18 other other JJ cord-297469-26d8o1xk 69 19 UA UA NNP cord-297469-26d8o1xk 69 20 - - HYPH cord-297469-26d8o1xk 69 21 treated treat VBN cord-297469-26d8o1xk 69 22 groups group NNS cord-297469-26d8o1xk 69 23 ( ( -LRB- cord-297469-26d8o1xk 69 24 Figure Figure NNP cord-297469-26d8o1xk 69 25 4 4 CD cord-297469-26d8o1xk 69 26 ) ) -RRB- cord-297469-26d8o1xk 69 27 , , , cord-297469-26d8o1xk 69 28 and and CC cord-297469-26d8o1xk 69 29 these these DT cord-297469-26d8o1xk 69 30 changes change NNS cord-297469-26d8o1xk 69 31 of of IN cord-297469-26d8o1xk 69 32 ROS ROS NNP cord-297469-26d8o1xk 69 33 activity activity NN cord-297469-26d8o1xk 69 34 show show VBP cord-297469-26d8o1xk 69 35 that that IN cord-297469-26d8o1xk 69 36 UA UA NNP cord-297469-26d8o1xk 69 37 acts act VBZ cord-297469-26d8o1xk 69 38 as as IN cord-297469-26d8o1xk 69 39 a a DT cord-297469-26d8o1xk 69 40 modulator modulator NN cord-297469-26d8o1xk 69 41 which which WDT cord-297469-26d8o1xk 69 42 consistently consistently RB cord-297469-26d8o1xk 69 43 inhibits inhibit VBZ cord-297469-26d8o1xk 69 44 the the DT cord-297469-26d8o1xk 69 45 proliferation proliferation NN cord-297469-26d8o1xk 69 46 and and CC cord-297469-26d8o1xk 69 47 the the DT cord-297469-26d8o1xk 69 48 growth growth NN cord-297469-26d8o1xk 69 49 of of IN cord-297469-26d8o1xk 69 50 T. t. NN cord-297469-26d8o1xk 69 51 gondii gondii NN cord-297469-26d8o1xk 69 52 by by IN cord-297469-26d8o1xk 69 53 promoting promote VBG cord-297469-26d8o1xk 69 54 the the DT cord-297469-26d8o1xk 69 55 production production NN cord-297469-26d8o1xk 69 56 of of IN cord-297469-26d8o1xk 69 57 ROS ROS NNP cord-297469-26d8o1xk 69 58 in in IN cord-297469-26d8o1xk 69 59 immune immune JJ cord-297469-26d8o1xk 69 60 cells cell NNS cord-297469-26d8o1xk 69 61 after after IN cord-297469-26d8o1xk 69 62 the the DT cord-297469-26d8o1xk 69 63 parasite parasite NN cord-297469-26d8o1xk 69 64 infection infection NN cord-297469-26d8o1xk 69 65 . . . cord-297469-26d8o1xk 70 1 Even even RB cord-297469-26d8o1xk 70 2 though though IN cord-297469-26d8o1xk 70 3 SF SF NNP cord-297469-26d8o1xk 70 4 - - HYPH cord-297469-26d8o1xk 70 5 treated treat VBN cord-297469-26d8o1xk 70 6 groups group NNS cord-297469-26d8o1xk 70 7 significantly significantly RB cord-297469-26d8o1xk 70 8 increased increase VBD cord-297469-26d8o1xk 70 9 ROS ROS NNP cord-297469-26d8o1xk 70 10 production production NN cord-297469-26d8o1xk 70 11 compared compare VBN cord-297469-26d8o1xk 70 12 to to IN cord-297469-26d8o1xk 70 13 the the DT cord-297469-26d8o1xk 70 14 T. T. NNP cord-297469-26d8o1xk 70 15 gondii gondii NN cord-297469-26d8o1xk 70 16 - - HYPH cord-297469-26d8o1xk 70 17 infected infect VBN cord-297469-26d8o1xk 70 18 group group NN cord-297469-26d8o1xk 70 19 , , , cord-297469-26d8o1xk 70 20 there there EX cord-297469-26d8o1xk 70 21 were be VBD cord-297469-26d8o1xk 70 22 low low JJ cord-297469-26d8o1xk 70 23 ROS ROS NNP cord-297469-26d8o1xk 70 24 - - HYPH cord-297469-26d8o1xk 70 25 productive productive JJ cord-297469-26d8o1xk 70 26 rates rate NNS cord-297469-26d8o1xk 70 27 compared compare VBN cord-297469-26d8o1xk 70 28 to to IN cord-297469-26d8o1xk 70 29 UA UA NNP cord-297469-26d8o1xk 70 30 - - HYPH cord-297469-26d8o1xk 70 31 treated treat VBN cord-297469-26d8o1xk 70 32 groups group NNS cord-297469-26d8o1xk 70 33 . . . cord-297469-26d8o1xk 71 1 Furthermore furthermore RB cord-297469-26d8o1xk 71 2 , , , cord-297469-26d8o1xk 71 3 the the DT cord-297469-26d8o1xk 71 4 rate rate NN cord-297469-26d8o1xk 71 5 of of IN cord-297469-26d8o1xk 71 6 NO no DT cord-297469-26d8o1xk 71 7 production production NN cord-297469-26d8o1xk 71 8 was be VBD cord-297469-26d8o1xk 71 9 strongly strongly RB cord-297469-26d8o1xk 71 10 increased increase VBN cord-297469-26d8o1xk 71 11 in in IN cord-297469-26d8o1xk 71 12 T. T. NNP cord-297469-26d8o1xk 71 13 gondii gondii NNP cord-297469-26d8o1xk 71 14 - - HYPH cord-297469-26d8o1xk 71 15 infected infect VBN cord-297469-26d8o1xk 71 16 group group NN cord-297469-26d8o1xk 71 17 treated treat VBN cord-297469-26d8o1xk 71 18 with with IN cord-297469-26d8o1xk 71 19 UA UA NNP cord-297469-26d8o1xk 71 20 compared compare VBN cord-297469-26d8o1xk 71 21 with with IN cord-297469-26d8o1xk 71 22 normal normal JJ cord-297469-26d8o1xk 71 23 and and CC cord-297469-26d8o1xk 71 24 T. t. NN cord-297469-26d8o1xk 71 25 gondii gondii NN cord-297469-26d8o1xk 71 26 - - HYPH cord-297469-26d8o1xk 71 27 infected infect VBN cord-297469-26d8o1xk 71 28 groups group NNS cord-297469-26d8o1xk 71 29 , , , cord-297469-26d8o1xk 71 30 but but CC cord-297469-26d8o1xk 71 31 in in IN cord-297469-26d8o1xk 71 32 the the DT cord-297469-26d8o1xk 71 33 range range NN cord-297469-26d8o1xk 71 34 of of IN cord-297469-26d8o1xk 71 35 100 100 CD cord-297469-26d8o1xk 71 36 μg μg NN cord-297469-26d8o1xk 71 37 / / SYM cord-297469-26d8o1xk 71 38 mL mL NNP cord-297469-26d8o1xk 71 39 of of IN cord-297469-26d8o1xk 71 40 UA UA NNP cord-297469-26d8o1xk 71 41 , , , cord-297469-26d8o1xk 71 42 the the DT cord-297469-26d8o1xk 71 43 rate rate NN cord-297469-26d8o1xk 71 44 of of IN cord-297469-26d8o1xk 71 45 NO no DT cord-297469-26d8o1xk 71 46 production production NN cord-297469-26d8o1xk 71 47 were be VBD cord-297469-26d8o1xk 71 48 low low JJ cord-297469-26d8o1xk 71 49 concentrations concentration NNS cord-297469-26d8o1xk 71 50 compared compare VBN cord-297469-26d8o1xk 71 51 with with IN cord-297469-26d8o1xk 71 52 other other JJ cord-297469-26d8o1xk 71 53 UA UA NNP cord-297469-26d8o1xk 71 54 - - HYPH cord-297469-26d8o1xk 71 55 treated treat VBN cord-297469-26d8o1xk 71 56 groups group NNS cord-297469-26d8o1xk 71 57 ( ( -LRB- cord-297469-26d8o1xk 71 58 Figure figure NN cord-297469-26d8o1xk 71 59 5 5 CD cord-297469-26d8o1xk 71 60 ) ) -RRB- cord-297469-26d8o1xk 71 61 . . . cord-297469-26d8o1xk 72 1 However however RB cord-297469-26d8o1xk 72 2 , , , cord-297469-26d8o1xk 72 3 the the DT cord-297469-26d8o1xk 72 4 activities activity NNS cord-297469-26d8o1xk 72 5 of of IN cord-297469-26d8o1xk 72 6 both both CC cord-297469-26d8o1xk 72 7 ROS ROS NNP cord-297469-26d8o1xk 72 8 and and CC cord-297469-26d8o1xk 72 9 NO no DT cord-297469-26d8o1xk 72 10 induced induce VBN cord-297469-26d8o1xk 72 11 by by IN cord-297469-26d8o1xk 72 12 UA UA NNP cord-297469-26d8o1xk 72 13 were be VBD cord-297469-26d8o1xk 72 14 significantly significantly RB cord-297469-26d8o1xk 72 15 increased increase VBN cord-297469-26d8o1xk 72 16 more more RBR cord-297469-26d8o1xk 72 17 than than IN cord-297469-26d8o1xk 72 18 normal normal JJ cord-297469-26d8o1xk 72 19 and and CC cord-297469-26d8o1xk 72 20 infection infection NN cord-297469-26d8o1xk 72 21 groups group NNS cord-297469-26d8o1xk 72 22 . . . cord-297469-26d8o1xk 73 1 Interestingly interestingly RB cord-297469-26d8o1xk 73 2 , , , cord-297469-26d8o1xk 73 3 the the DT cord-297469-26d8o1xk 73 4 activities activity NNS cord-297469-26d8o1xk 73 5 of of IN cord-297469-26d8o1xk 73 6 ROS ROS NNP cord-297469-26d8o1xk 73 7 and and CC cord-297469-26d8o1xk 73 8 NO no UH cord-297469-26d8o1xk 73 9 in in IN cord-297469-26d8o1xk 73 10 T. t. NN cord-297469-26d8o1xk 73 11 gondii gondii NN cord-297469-26d8o1xk 73 12 - - HYPH cord-297469-26d8o1xk 73 13 infected infect VBN cord-297469-26d8o1xk 73 14 cells cell NNS cord-297469-26d8o1xk 73 15 treated treat VBN cord-297469-26d8o1xk 73 16 with with IN cord-297469-26d8o1xk 73 17 SF SF NNP cord-297469-26d8o1xk 73 18 were be VBD cord-297469-26d8o1xk 73 19 lower low JJR cord-297469-26d8o1xk 73 20 than than IN cord-297469-26d8o1xk 73 21 T. T. NNP cord-297469-26d8o1xk 73 22 gondii gondii NN cord-297469-26d8o1xk 73 23 - - HYPH cord-297469-26d8o1xk 73 24 infected infect VBN cord-297469-26d8o1xk 73 25 groups group NNS cord-297469-26d8o1xk 73 26 treated treat VBN cord-297469-26d8o1xk 73 27 with with IN cord-297469-26d8o1xk 73 28 UA UA NNP cord-297469-26d8o1xk 73 29 . . . cord-297469-26d8o1xk 74 1 The the DT cord-297469-26d8o1xk 74 2 activities activity NNS cord-297469-26d8o1xk 74 3 of of IN cord-297469-26d8o1xk 74 4 ROS ROS NNP cord-297469-26d8o1xk 74 5 and and CC cord-297469-26d8o1xk 74 6 NO no DT cord-297469-26d8o1xk 74 7 were be VBD cord-297469-26d8o1xk 74 8 significantly significantly RB cord-297469-26d8o1xk 74 9 increased increase VBN cord-297469-26d8o1xk 74 10 in in IN cord-297469-26d8o1xk 74 11 T. T. NNP cord-297469-26d8o1xk 74 12 gondii gondii NN cord-297469-26d8o1xk 74 13 - - HYPH cord-297469-26d8o1xk 74 14 infected infect VBN cord-297469-26d8o1xk 74 15 groups group NNS cord-297469-26d8o1xk 74 16 treated treat VBN cord-297469-26d8o1xk 74 17 with with IN cord-297469-26d8o1xk 74 18 UA UA NNP cord-297469-26d8o1xk 74 19 and and CC cord-297469-26d8o1xk 74 20 SF SF NNP cord-297469-26d8o1xk 74 21 , , , cord-297469-26d8o1xk 74 22 respectively respectively RB cord-297469-26d8o1xk 74 23 , , , cord-297469-26d8o1xk 74 24 whereas whereas IN cord-297469-26d8o1xk 74 25 their -PRON- PRP$ cord-297469-26d8o1xk 74 26 activities activity NNS cord-297469-26d8o1xk 74 27 were be VBD cord-297469-26d8o1xk 74 28 gradually gradually RB cord-297469-26d8o1xk 74 29 reduced reduce VBN cord-297469-26d8o1xk 74 30 in in IN cord-297469-26d8o1xk 74 31 high high JJ cord-297469-26d8o1xk 74 32 concentrations concentration NNS cord-297469-26d8o1xk 74 33 . . . cord-297469-26d8o1xk 75 1 These these DT cord-297469-26d8o1xk 75 2 results result NNS cord-297469-26d8o1xk 75 3 show show VBP cord-297469-26d8o1xk 75 4 that that IN cord-297469-26d8o1xk 75 5 UA UA NNP cord-297469-26d8o1xk 75 6 not not RB cord-297469-26d8o1xk 75 7 only only RB cord-297469-26d8o1xk 75 8 consistently consistently RB cord-297469-26d8o1xk 75 9 induces induce VBZ cord-297469-26d8o1xk 75 10 the the DT cord-297469-26d8o1xk 75 11 production production NN cord-297469-26d8o1xk 75 12 of of IN cord-297469-26d8o1xk 75 13 ROS ROS NNP cord-297469-26d8o1xk 75 14 and and CC cord-297469-26d8o1xk 75 15 NO no UH cord-297469-26d8o1xk 75 16 through through IN cord-297469-26d8o1xk 75 17 the the DT cord-297469-26d8o1xk 75 18 interaction interaction NN cord-297469-26d8o1xk 75 19 between between IN cord-297469-26d8o1xk 75 20 it -PRON- PRP cord-297469-26d8o1xk 75 21 and and CC cord-297469-26d8o1xk 75 22 immune immune JJ cord-297469-26d8o1xk 75 23 cells cell NNS cord-297469-26d8o1xk 75 24 in in IN cord-297469-26d8o1xk 75 25 T. T. NNP cord-297469-26d8o1xk 75 26 gondii gondii NN cord-297469-26d8o1xk 75 27 - - HYPH cord-297469-26d8o1xk 75 28 infected infect VBN cord-297469-26d8o1xk 75 29 immune immune JJ cord-297469-26d8o1xk 75 30 cells cell NNS cord-297469-26d8o1xk 75 31 , , , cord-297469-26d8o1xk 75 32 but but CC cord-297469-26d8o1xk 75 33 may may MD cord-297469-26d8o1xk 75 34 also also RB cord-297469-26d8o1xk 75 35 be be VB cord-297469-26d8o1xk 75 36 used use VBN cord-297469-26d8o1xk 75 37 as as IN cord-297469-26d8o1xk 75 38 a a DT cord-297469-26d8o1xk 75 39 synergic synergic JJ cord-297469-26d8o1xk 75 40 compound compound NN cord-297469-26d8o1xk 75 41 for for IN cord-297469-26d8o1xk 75 42 the the DT cord-297469-26d8o1xk 75 43 immunomodulation immunomodulation NN cord-297469-26d8o1xk 75 44 after after IN cord-297469-26d8o1xk 75 45 parasitic parasitic JJ cord-297469-26d8o1xk 75 46 infection infection NN cord-297469-26d8o1xk 75 47 . . . cord-297469-26d8o1xk 75 48 _SP cord-297469-26d8o1xk 76 1 T. t. NN cord-297469-26d8o1xk 76 2 gondii gondii NN cord-297469-26d8o1xk 76 3 proliferates proliferate VBZ cord-297469-26d8o1xk 76 4 rapidly rapidly RB cord-297469-26d8o1xk 76 5 in in IN cord-297469-26d8o1xk 76 6 host host NN cord-297469-26d8o1xk 76 7 cells cell NNS cord-297469-26d8o1xk 76 8 through through IN cord-297469-26d8o1xk 76 9 parasitic parasitic JJ cord-297469-26d8o1xk 76 10 interactions interaction NNS cord-297469-26d8o1xk 76 11 and and CC cord-297469-26d8o1xk 76 12 signals signal NNS cord-297469-26d8o1xk 76 13 for for IN cord-297469-26d8o1xk 76 14 its -PRON- PRP$ cord-297469-26d8o1xk 76 15 survival survival NN cord-297469-26d8o1xk 76 16 after after IN cord-297469-26d8o1xk 76 17 cell cell NN cord-297469-26d8o1xk 76 18 invasion invasion NN cord-297469-26d8o1xk 76 19 , , , cord-297469-26d8o1xk 76 20 which which WDT cord-297469-26d8o1xk 76 21 finally finally RB cord-297469-26d8o1xk 76 22 induces induce VBZ cord-297469-26d8o1xk 76 23 destruction destruction NN cord-297469-26d8o1xk 76 24 of of IN cord-297469-26d8o1xk 76 25 host host NN cord-297469-26d8o1xk 76 26 cells cell NNS cord-297469-26d8o1xk 76 27 . . . cord-297469-26d8o1xk 77 1 We -PRON- PRP cord-297469-26d8o1xk 77 2 evaluated evaluate VBD cord-297469-26d8o1xk 77 3 the the DT cord-297469-26d8o1xk 77 4 synergic synergic JJ cord-297469-26d8o1xk 77 5 effect effect NN cord-297469-26d8o1xk 77 6 and and CC cord-297469-26d8o1xk 77 7 the the DT cord-297469-26d8o1xk 77 8 activation activation NN cord-297469-26d8o1xk 77 9 of of IN cord-297469-26d8o1xk 77 10 cytokines cytokine NNS cord-297469-26d8o1xk 77 11 caused cause VBN cord-297469-26d8o1xk 77 12 by by IN cord-297469-26d8o1xk 77 13 ursolic ursolic JJ cord-297469-26d8o1xk 77 14 acid acid NN cord-297469-26d8o1xk 77 15 in in IN cord-297469-26d8o1xk 77 16 co co JJ cord-297469-26d8o1xk 77 17 - - JJ cord-297469-26d8o1xk 77 18 cultured cultured JJ cord-297469-26d8o1xk 77 19 immune immune JJ cord-297469-26d8o1xk 77 20 cells cell NNS cord-297469-26d8o1xk 77 21 ( ( -LRB- cord-297469-26d8o1xk 77 22 macrophages macrophage NNS cord-297469-26d8o1xk 77 23 , , , cord-297469-26d8o1xk 77 24 T t NN cord-297469-26d8o1xk 77 25 cells cell NNS cord-297469-26d8o1xk 77 26 , , , cord-297469-26d8o1xk 77 27 B b NN cord-297469-26d8o1xk 77 28 cells cell NNS cord-297469-26d8o1xk 77 29 and and CC cord-297469-26d8o1xk 77 30 basophil basophil NNP cord-297469-26d8o1xk 77 31 cells cell NNS cord-297469-26d8o1xk 77 32 ) ) -RRB- cord-297469-26d8o1xk 77 33 infected infect VBN cord-297469-26d8o1xk 77 34 with with IN cord-297469-26d8o1xk 77 35 T. t. NN cord-297469-26d8o1xk 77 36 gondii gondii NNP cord-297469-26d8o1xk 77 37 . . . cord-297469-26d8o1xk 78 1 The the DT cord-297469-26d8o1xk 78 2 production production NN cord-297469-26d8o1xk 78 3 of of IN cord-297469-26d8o1xk 78 4 the the DT cord-297469-26d8o1xk 78 5 cytokines cytokine NNS cord-297469-26d8o1xk 78 6 ( ( -LRB- cord-297469-26d8o1xk 78 7 interferon interferon NN cord-297469-26d8o1xk 78 8 - - HYPH cord-297469-26d8o1xk 78 9 β β NNP cord-297469-26d8o1xk 78 10 , , , cord-297469-26d8o1xk 78 11 granulocyte granulocyte NNP cord-297469-26d8o1xk 78 12 macrophage macrophage NN cord-297469-26d8o1xk 78 13 colony colony NN cord-297469-26d8o1xk 78 14 stimulating stimulate VBG cord-297469-26d8o1xk 78 15 factor factor NN cord-297469-26d8o1xk 78 16 ( ( -LRB- cord-297469-26d8o1xk 78 17 GM GM NNP cord-297469-26d8o1xk 78 18 - - HYPH cord-297469-26d8o1xk 78 19 CSF CSF NNP cord-297469-26d8o1xk 78 20 ) ) -RRB- cord-297469-26d8o1xk 78 21 , , , cord-297469-26d8o1xk 78 22 transforming transform VBG cord-297469-26d8o1xk 78 23 growth growth NN cord-297469-26d8o1xk 78 24 factor factor NN cord-297469-26d8o1xk 78 25 beta beta NN cord-297469-26d8o1xk 78 26 1 1 CD cord-297469-26d8o1xk 78 27 ( ( -LRB- cord-297469-26d8o1xk 78 28 TGF TGF NNP cord-297469-26d8o1xk 78 29 - - HYPH cord-297469-26d8o1xk 78 30 β1 β1 NNP cord-297469-26d8o1xk 78 31 ) ) -RRB- cord-297469-26d8o1xk 78 32 , , , cord-297469-26d8o1xk 78 33 and and CC cord-297469-26d8o1xk 78 34 tumor tumor NN cord-297469-26d8o1xk 78 35 necrosis necrosis NN cord-297469-26d8o1xk 78 36 factor factor NN cord-297469-26d8o1xk 78 37 alpha alpha NN cord-297469-26d8o1xk 78 38 ( ( -LRB- cord-297469-26d8o1xk 78 39 TNF TNF NNP cord-297469-26d8o1xk 78 40 - - HYPH cord-297469-26d8o1xk 78 41 α α NNP cord-297469-26d8o1xk 78 42 ) ) -RRB- cord-297469-26d8o1xk 78 43 ) ) -RRB- cord-297469-26d8o1xk 78 44 in in IN cord-297469-26d8o1xk 78 45 T. T. NNP cord-297469-26d8o1xk 78 46 gondii gondii NN cord-297469-26d8o1xk 78 47 - - HYPH cord-297469-26d8o1xk 78 48 infected infect VBN cord-297469-26d8o1xk 78 49 immune immune JJ cord-297469-26d8o1xk 78 50 cells cell NNS cord-297469-26d8o1xk 78 51 was be VBD cord-297469-26d8o1xk 78 52 notably notably RB cord-297469-26d8o1xk 78 53 changed change VBN cord-297469-26d8o1xk 78 54 in in IN cord-297469-26d8o1xk 78 55 a a DT cord-297469-26d8o1xk 78 56 concentration concentration NN cord-297469-26d8o1xk 78 57 - - HYPH cord-297469-26d8o1xk 78 58 dependent dependent JJ cord-297469-26d8o1xk 78 59 manner manner NN cord-297469-26d8o1xk 78 60 when when WRB cord-297469-26d8o1xk 78 61 the the DT cord-297469-26d8o1xk 78 62 cells cell NNS cord-297469-26d8o1xk 78 63 were be VBD cord-297469-26d8o1xk 78 64 incubated incubate VBN cord-297469-26d8o1xk 78 65 with with IN cord-297469-26d8o1xk 78 66 different different JJ cord-297469-26d8o1xk 78 67 concentrations concentration NNS cord-297469-26d8o1xk 78 68 ( ( -LRB- cord-297469-26d8o1xk 78 69 25 25 CD cord-297469-26d8o1xk 78 70 - - SYM cord-297469-26d8o1xk 78 71 100 100 CD cord-297469-26d8o1xk 78 72 μg μg NNP cord-297469-26d8o1xk 78 73 / / SYM cord-297469-26d8o1xk 78 74 mL mL NNP cord-297469-26d8o1xk 78 75 ) ) -RRB- cord-297469-26d8o1xk 78 76 of of IN cord-297469-26d8o1xk 78 77 UA UA NNP cord-297469-26d8o1xk 78 78 , , , cord-297469-26d8o1xk 78 79 and and CC cord-297469-26d8o1xk 78 80 their -PRON- PRP$ cord-297469-26d8o1xk 78 81 changes change NNS cord-297469-26d8o1xk 78 82 were be VBD cord-297469-26d8o1xk 78 83 measured measure VBN cord-297469-26d8o1xk 78 84 under under IN cord-297469-26d8o1xk 78 85 an an DT cord-297469-26d8o1xk 78 86 ELISA ELISA NNP cord-297469-26d8o1xk 78 87 reader reader NN cord-297469-26d8o1xk 78 88 . . . cord-297469-26d8o1xk 79 1 In in IN cord-297469-26d8o1xk 79 2 particular particular JJ cord-297469-26d8o1xk 79 3 , , , cord-297469-26d8o1xk 79 4 the the DT cord-297469-26d8o1xk 79 5 production production NN cord-297469-26d8o1xk 79 6 of of IN cord-297469-26d8o1xk 79 7 interferon interferon NN cord-297469-26d8o1xk 79 8 - - HYPH cord-297469-26d8o1xk 79 9 β β NN cord-297469-26d8o1xk 79 10 and and CC cord-297469-26d8o1xk 79 11 GM GM NNP cord-297469-26d8o1xk 79 12 - - HYPH cord-297469-26d8o1xk 79 13 CSF CSF NNP cord-297469-26d8o1xk 79 14 was be VBD cord-297469-26d8o1xk 79 15 effectively effectively RB cord-297469-26d8o1xk 79 16 increased increase VBN cord-297469-26d8o1xk 79 17 in in IN cord-297469-26d8o1xk 79 18 T. T. NNP cord-297469-26d8o1xk 79 19 gondii gondii NN cord-297469-26d8o1xk 79 20 - - HYPH cord-297469-26d8o1xk 79 21 infected infect VBN cord-297469-26d8o1xk 79 22 cells cell NNS cord-297469-26d8o1xk 79 23 treated treat VBN cord-297469-26d8o1xk 79 24 with with IN cord-297469-26d8o1xk 79 25 UA UA NNP cord-297469-26d8o1xk 79 26 compared compare VBN cord-297469-26d8o1xk 79 27 with with IN cord-297469-26d8o1xk 79 28 T. T. NNP cord-297469-26d8o1xk 79 29 gondii gondii NN cord-297469-26d8o1xk 79 30 - - HYPH cord-297469-26d8o1xk 79 31 infected infect VBN cord-297469-26d8o1xk 79 32 cells cell NNS cord-297469-26d8o1xk 79 33 , , , cord-297469-26d8o1xk 79 34 and and CC cord-297469-26d8o1xk 79 35 these these DT cord-297469-26d8o1xk 79 36 changes change NNS cord-297469-26d8o1xk 79 37 show show VBP cord-297469-26d8o1xk 79 38 that that IN cord-297469-26d8o1xk 79 39 UA UA NNP cord-297469-26d8o1xk 79 40 accelerated accelerate VBD cord-297469-26d8o1xk 79 41 the the DT cord-297469-26d8o1xk 79 42 production production NN cord-297469-26d8o1xk 79 43 and and CC cord-297469-26d8o1xk 79 44 release release NN cord-297469-26d8o1xk 79 45 of of IN cord-297469-26d8o1xk 79 46 interferon interferon NN cord-297469-26d8o1xk 79 47 - - HYPH cord-297469-26d8o1xk 79 48 β β NN cord-297469-26d8o1xk 79 49 and and CC cord-297469-26d8o1xk 79 50 GM GM NNP cord-297469-26d8o1xk 79 51 - - HYPH cord-297469-26d8o1xk 79 52 CSF CSF NNP cord-297469-26d8o1xk 79 53 by by IN cord-297469-26d8o1xk 79 54 stimulating stimulate VBG cord-297469-26d8o1xk 79 55 the the DT cord-297469-26d8o1xk 79 56 macrophage macrophage NN cord-297469-26d8o1xk 79 57 , , , cord-297469-26d8o1xk 79 58 B b NN cord-297469-26d8o1xk 79 59 cells cell NNS cord-297469-26d8o1xk 79 60 , , , cord-297469-26d8o1xk 79 61 and and CC cord-297469-26d8o1xk 79 62 basophil basophil NNP cord-297469-26d8o1xk 79 63 cells cell NNS cord-297469-26d8o1xk 79 64 ( ( -LRB- cord-297469-26d8o1xk 79 65 Figure Figure NNP cord-297469-26d8o1xk 79 66 6 6 CD cord-297469-26d8o1xk 79 67 ) ) -RRB- cord-297469-26d8o1xk 79 68 . . . cord-297469-26d8o1xk 80 1 Moreover moreover RB cord-297469-26d8o1xk 80 2 , , , cord-297469-26d8o1xk 80 3 the the DT cord-297469-26d8o1xk 80 4 production production NN cord-297469-26d8o1xk 80 5 of of IN cord-297469-26d8o1xk 80 6 interferon interferon NN cord-297469-26d8o1xk 80 7 - - HYPH cord-297469-26d8o1xk 80 8 β β NNP cord-297469-26d8o1xk 80 9 was be VBD cord-297469-26d8o1xk 80 10 not not RB cord-297469-26d8o1xk 80 11 changed change VBN cord-297469-26d8o1xk 80 12 in in IN cord-297469-26d8o1xk 80 13 SF SF NNP cord-297469-26d8o1xk 80 14 - - HYPH cord-297469-26d8o1xk 80 15 treated treat VBN cord-297469-26d8o1xk 80 16 groups group NNS cord-297469-26d8o1xk 80 17 , , , cord-297469-26d8o1xk 80 18 and and CC cord-297469-26d8o1xk 80 19 the the DT cord-297469-26d8o1xk 80 20 production production NN cord-297469-26d8o1xk 80 21 of of IN cord-297469-26d8o1xk 80 22 GM GM NNP cord-297469-26d8o1xk 80 23 - - HYPH cord-297469-26d8o1xk 80 24 CSF CSF NNP cord-297469-26d8o1xk 80 25 was be VBD cord-297469-26d8o1xk 80 26 gradually gradually RB cord-297469-26d8o1xk 80 27 decreased decrease VBN cord-297469-26d8o1xk 80 28 . . . cord-297469-26d8o1xk 81 1 Furthermore furthermore RB cord-297469-26d8o1xk 81 2 , , , cord-297469-26d8o1xk 81 3 the the DT cord-297469-26d8o1xk 81 4 expression expression NN cord-297469-26d8o1xk 81 5 of of IN cord-297469-26d8o1xk 81 6 TGF TGF NNP cord-297469-26d8o1xk 81 7 - - HYPH cord-297469-26d8o1xk 81 8 β1 β1 NNP cord-297469-26d8o1xk 81 9 and and CC cord-297469-26d8o1xk 81 10 TNF TNF NNP cord-297469-26d8o1xk 81 11 - - HYPH cord-297469-26d8o1xk 81 12 α α NNP cord-297469-26d8o1xk 81 13 was be VBD cord-297469-26d8o1xk 81 14 markedly markedly RB cord-297469-26d8o1xk 81 15 reduced reduce VBN cord-297469-26d8o1xk 81 16 in in IN cord-297469-26d8o1xk 81 17 T. T. NNP cord-297469-26d8o1xk 81 18 gondii gondii NN cord-297469-26d8o1xk 81 19 - - HYPH cord-297469-26d8o1xk 81 20 infected infect VBN cord-297469-26d8o1xk 81 21 cells cell NNS cord-297469-26d8o1xk 81 22 treated treat VBN cord-297469-26d8o1xk 81 23 with with IN cord-297469-26d8o1xk 81 24 UA UA NNP cord-297469-26d8o1xk 81 25 , , , cord-297469-26d8o1xk 81 26 whereas whereas IN cord-297469-26d8o1xk 81 27 T. T. NNP cord-297469-26d8o1xk 81 28 gondii gondii NN cord-297469-26d8o1xk 81 29 - - HYPH cord-297469-26d8o1xk 81 30 infected infect VBN cord-297469-26d8o1xk 81 31 cells cell NNS cord-297469-26d8o1xk 81 32 treated treat VBN cord-297469-26d8o1xk 81 33 with with IN cord-297469-26d8o1xk 81 34 SF SF NNP cord-297469-26d8o1xk 81 35 did do VBD cord-297469-26d8o1xk 81 36 not not RB cord-297469-26d8o1xk 81 37 cause cause VB cord-297469-26d8o1xk 81 38 the the DT cord-297469-26d8o1xk 81 39 production production NN cord-297469-26d8o1xk 81 40 of of IN cord-297469-26d8o1xk 81 41 TGF TGF NNP cord-297469-26d8o1xk 81 42 - - HYPH cord-297469-26d8o1xk 81 43 β1 β1 NNP cord-297469-26d8o1xk 81 44 and and CC cord-297469-26d8o1xk 81 45 TNFα TNFα NNS cord-297469-26d8o1xk 81 46 compared compare VBN cord-297469-26d8o1xk 81 47 with with IN cord-297469-26d8o1xk 81 48 other other JJ cord-297469-26d8o1xk 81 49 groups group NNS cord-297469-26d8o1xk 81 50 ( ( -LRB- cord-297469-26d8o1xk 81 51 Figure Figure NNP cord-297469-26d8o1xk 81 52 7 7 CD cord-297469-26d8o1xk 81 53 ) ) -RRB- cord-297469-26d8o1xk 81 54 . . . cord-297469-26d8o1xk 82 1 Interestingly interestingly RB cord-297469-26d8o1xk 82 2 , , , cord-297469-26d8o1xk 82 3 T. T. NNP cord-297469-26d8o1xk 82 4 gondii gondii NN cord-297469-26d8o1xk 82 5 - - HYPH cord-297469-26d8o1xk 82 6 infected infect VBN cord-297469-26d8o1xk 82 7 cells cell NNS cord-297469-26d8o1xk 82 8 treated treat VBN cord-297469-26d8o1xk 82 9 with with IN cord-297469-26d8o1xk 82 10 SF SF NNP cord-297469-26d8o1xk 82 11 did do VBD cord-297469-26d8o1xk 82 12 not not RB cord-297469-26d8o1xk 82 13 significantly significantly RB cord-297469-26d8o1xk 82 14 produce produce VB cord-297469-26d8o1xk 82 15 the the DT cord-297469-26d8o1xk 82 16 expression expression NN cord-297469-26d8o1xk 82 17 of of IN cord-297469-26d8o1xk 82 18 Interferon Interferon NNP cord-297469-26d8o1xk 82 19 - - HYPH cord-297469-26d8o1xk 82 20 β β NNP cord-297469-26d8o1xk 82 21 , , , cord-297469-26d8o1xk 82 22 TGF TGF NNP cord-297469-26d8o1xk 82 23 - - HYPH cord-297469-26d8o1xk 82 24 β1 β1 NNP cord-297469-26d8o1xk 82 25 and and CC cord-297469-26d8o1xk 82 26 TNF TNF NNP cord-297469-26d8o1xk 82 27 - - HYPH cord-297469-26d8o1xk 82 28 α α NNP cord-297469-26d8o1xk 82 29 compared compare VBN cord-297469-26d8o1xk 82 30 to to IN cord-297469-26d8o1xk 82 31 the the DT cord-297469-26d8o1xk 82 32 infected infected JJ cord-297469-26d8o1xk 82 33 group group NN cord-297469-26d8o1xk 82 34 . . . cord-297469-26d8o1xk 83 1 This this DT cord-297469-26d8o1xk 83 2 shows show VBZ cord-297469-26d8o1xk 83 3 that that IN cord-297469-26d8o1xk 83 4 SF SF NNP cord-297469-26d8o1xk 83 5 is be VBZ cord-297469-26d8o1xk 83 6 not not RB cord-297469-26d8o1xk 83 7 involved involve VBN cord-297469-26d8o1xk 83 8 in in IN cord-297469-26d8o1xk 83 9 immune immune JJ cord-297469-26d8o1xk 83 10 response response NN cord-297469-26d8o1xk 83 11 for for IN cord-297469-26d8o1xk 83 12 expressing express VBG cord-297469-26d8o1xk 83 13 TNF TNF NNP cord-297469-26d8o1xk 83 14 - - HYPH cord-297469-26d8o1xk 83 15 α α NNP cord-297469-26d8o1xk 83 16 , , , cord-297469-26d8o1xk 83 17 TGF TGF NNP cord-297469-26d8o1xk 83 18 - - HYPH cord-297469-26d8o1xk 83 19 β1 β1 NNP cord-297469-26d8o1xk 83 20 , , , cord-297469-26d8o1xk 83 21 and and CC cord-297469-26d8o1xk 83 22 interferon interferon NN cord-297469-26d8o1xk 83 23 - - HYPH cord-297469-26d8o1xk 83 24 β β NN cord-297469-26d8o1xk 83 25 in in IN cord-297469-26d8o1xk 83 26 immune immune JJ cord-297469-26d8o1xk 83 27 cells cell NNS cord-297469-26d8o1xk 83 28 . . . cord-297469-26d8o1xk 84 1 Furthermore furthermore RB cord-297469-26d8o1xk 84 2 , , , cord-297469-26d8o1xk 84 3 the the DT cord-297469-26d8o1xk 84 4 production production NN cord-297469-26d8o1xk 84 5 of of IN cord-297469-26d8o1xk 84 6 TGF TGF NNP cord-297469-26d8o1xk 84 7 - - HYPH cord-297469-26d8o1xk 84 8 β1 β1 NNP cord-297469-26d8o1xk 84 9 was be VBD cord-297469-26d8o1xk 84 10 decreased decrease VBN cord-297469-26d8o1xk 84 11 in in IN cord-297469-26d8o1xk 84 12 T. T. NNP cord-297469-26d8o1xk 84 13 gondiiinfected gondiiinfecte VBN cord-297469-26d8o1xk 84 14 cells cell NNS cord-297469-26d8o1xk 84 15 treated treat VBN cord-297469-26d8o1xk 84 16 with with IN cord-297469-26d8o1xk 84 17 UA UA NNP cord-297469-26d8o1xk 84 18 , , , cord-297469-26d8o1xk 84 19 but but CC cord-297469-26d8o1xk 84 20 the the DT cord-297469-26d8o1xk 84 21 result result NN cord-297469-26d8o1xk 84 22 shows show VBZ cord-297469-26d8o1xk 84 23 that that IN cord-297469-26d8o1xk 84 24 UA UA NNP cord-297469-26d8o1xk 84 25 reduced reduce VBD cord-297469-26d8o1xk 84 26 the the DT cord-297469-26d8o1xk 84 27 expression expression NN cord-297469-26d8o1xk 84 28 of of IN cord-297469-26d8o1xk 84 29 TGF TGF NNP cord-297469-26d8o1xk 84 30 - - HYPH cord-297469-26d8o1xk 84 31 β1 β1 NNP cord-297469-26d8o1xk 84 32 in in IN cord-297469-26d8o1xk 84 33 immune immune JJ cord-297469-26d8o1xk 84 34 cells cell NNS cord-297469-26d8o1xk 84 35 by by IN cord-297469-26d8o1xk 84 36 directly directly RB cord-297469-26d8o1xk 84 37 inhibiting inhibit VBG cord-297469-26d8o1xk 84 38 T. t. NN cord-297469-26d8o1xk 84 39 gondii gondii NN cord-297469-26d8o1xk 84 40 . . . cord-297469-26d8o1xk 85 1 These these DT cord-297469-26d8o1xk 85 2 results result NNS cord-297469-26d8o1xk 85 3 demonstrate demonstrate VBP cord-297469-26d8o1xk 85 4 that that IN cord-297469-26d8o1xk 85 5 UA UA NNP cord-297469-26d8o1xk 85 6 not not RB cord-297469-26d8o1xk 85 7 only only RB cord-297469-26d8o1xk 85 8 promotes promote VBZ cord-297469-26d8o1xk 85 9 defense defense NN cord-297469-26d8o1xk 85 10 against against IN cord-297469-26d8o1xk 85 11 parasitic parasitic JJ cord-297469-26d8o1xk 85 12 infection infection NN cord-297469-26d8o1xk 85 13 by by IN cord-297469-26d8o1xk 85 14 effectively effectively RB cord-297469-26d8o1xk 85 15 inducing induce VBG cord-297469-26d8o1xk 85 16 the the DT cord-297469-26d8o1xk 85 17 production production NN cord-297469-26d8o1xk 85 18 of of IN cord-297469-26d8o1xk 85 19 Interferon Interferon NNP cord-297469-26d8o1xk 85 20 - - HYPH cord-297469-26d8o1xk 85 21 β β NNP cord-297469-26d8o1xk 85 22 and and CC cord-297469-26d8o1xk 85 23 GM GM NNP cord-297469-26d8o1xk 85 24 - - HYPH cord-297469-26d8o1xk 85 25 CSF CSF NNP cord-297469-26d8o1xk 85 26 from from IN cord-297469-26d8o1xk 85 27 immune immune JJ cord-297469-26d8o1xk 85 28 cells cell NNS cord-297469-26d8o1xk 85 29 when when WRB cord-297469-26d8o1xk 85 30 the the DT cord-297469-26d8o1xk 85 31 cells cell NNS cord-297469-26d8o1xk 85 32 are be VBP cord-297469-26d8o1xk 85 33 infected infect VBN cord-297469-26d8o1xk 85 34 with with IN cord-297469-26d8o1xk 85 35 T. t. NN cord-297469-26d8o1xk 85 36 gondii gondii NN cord-297469-26d8o1xk 85 37 , , , cord-297469-26d8o1xk 85 38 but but CC cord-297469-26d8o1xk 85 39 also also RB cord-297469-26d8o1xk 85 40 inhibits inhibit VBZ cord-297469-26d8o1xk 85 41 the the DT cord-297469-26d8o1xk 85 42 overexpression overexpression NN cord-297469-26d8o1xk 85 43 of of IN cord-297469-26d8o1xk 85 44 inflammatory inflammatory JJ cord-297469-26d8o1xk 85 45 cytokine cytokine NN cord-297469-26d8o1xk 85 46 by by IN cord-297469-26d8o1xk 85 47 reducing reduce VBG cord-297469-26d8o1xk 85 48 the the DT cord-297469-26d8o1xk 85 49 expression expression NN cord-297469-26d8o1xk 85 50 of of IN cord-297469-26d8o1xk 85 51 TNF TNF NNP cord-297469-26d8o1xk 85 52 - - HYPH cord-297469-26d8o1xk 85 53 α α NNP cord-297469-26d8o1xk 85 54 caused cause VBN cord-297469-26d8o1xk 85 55 by by IN cord-297469-26d8o1xk 85 56 infection infection NN cord-297469-26d8o1xk 85 57 . . . cord-297469-26d8o1xk 85 58 _SP cord-297469-26d8o1xk 86 1 T. t. NN cord-297469-26d8o1xk 86 2 gondii gondii NN cord-297469-26d8o1xk 86 3 proliferates proliferate VBZ cord-297469-26d8o1xk 86 4 rapidly rapidly RB cord-297469-26d8o1xk 86 5 in in IN cord-297469-26d8o1xk 86 6 host host NN cord-297469-26d8o1xk 86 7 cells cell NNS cord-297469-26d8o1xk 86 8 through through IN cord-297469-26d8o1xk 86 9 parasitic parasitic JJ cord-297469-26d8o1xk 86 10 interactions interaction NNS cord-297469-26d8o1xk 86 11 and and CC cord-297469-26d8o1xk 86 12 signals signal NNS cord-297469-26d8o1xk 86 13 for for IN cord-297469-26d8o1xk 86 14 its -PRON- PRP$ cord-297469-26d8o1xk 86 15 survival survival NN cord-297469-26d8o1xk 86 16 after after IN cord-297469-26d8o1xk 86 17 cell cell NN cord-297469-26d8o1xk 86 18 invasion invasion NN cord-297469-26d8o1xk 86 19 , , , cord-297469-26d8o1xk 86 20 which which WDT cord-297469-26d8o1xk 86 21 finally finally RB cord-297469-26d8o1xk 86 22 induces induce VBZ cord-297469-26d8o1xk 86 23 destruction destruction NN cord-297469-26d8o1xk 86 24 of of IN cord-297469-26d8o1xk 86 25 host host NN cord-297469-26d8o1xk 86 26 cells cell NNS cord-297469-26d8o1xk 86 27 . . . cord-297469-26d8o1xk 87 1 We -PRON- PRP cord-297469-26d8o1xk 87 2 evaluated evaluate VBD cord-297469-26d8o1xk 87 3 the the DT cord-297469-26d8o1xk 87 4 synergic synergic JJ cord-297469-26d8o1xk 87 5 effect effect NN cord-297469-26d8o1xk 87 6 and and CC cord-297469-26d8o1xk 87 7 the the DT cord-297469-26d8o1xk 87 8 activation activation NN cord-297469-26d8o1xk 87 9 of of IN cord-297469-26d8o1xk 87 10 cytokines cytokine NNS cord-297469-26d8o1xk 87 11 caused cause VBN cord-297469-26d8o1xk 87 12 by by IN cord-297469-26d8o1xk 87 13 ursolic ursolic JJ cord-297469-26d8o1xk 87 14 acid acid NN cord-297469-26d8o1xk 87 15 in in IN cord-297469-26d8o1xk 87 16 co co JJ cord-297469-26d8o1xk 87 17 - - JJ cord-297469-26d8o1xk 87 18 cultured cultured JJ cord-297469-26d8o1xk 87 19 immune immune JJ cord-297469-26d8o1xk 87 20 cells cell NNS cord-297469-26d8o1xk 87 21 ( ( -LRB- cord-297469-26d8o1xk 87 22 macrophages macrophage NNS cord-297469-26d8o1xk 87 23 , , , cord-297469-26d8o1xk 87 24 T t NN cord-297469-26d8o1xk 87 25 cells cell NNS cord-297469-26d8o1xk 87 26 , , , cord-297469-26d8o1xk 87 27 B b NN cord-297469-26d8o1xk 87 28 cells cell NNS cord-297469-26d8o1xk 87 29 and and CC cord-297469-26d8o1xk 87 30 basophil basophil NNP cord-297469-26d8o1xk 87 31 cells cell NNS cord-297469-26d8o1xk 87 32 ) ) -RRB- cord-297469-26d8o1xk 87 33 infected infect VBN cord-297469-26d8o1xk 87 34 with with IN cord-297469-26d8o1xk 87 35 T. t. NN cord-297469-26d8o1xk 87 36 gondii gondii NNP cord-297469-26d8o1xk 87 37 . . . cord-297469-26d8o1xk 88 1 The the DT cord-297469-26d8o1xk 88 2 production production NN cord-297469-26d8o1xk 88 3 of of IN cord-297469-26d8o1xk 88 4 the the DT cord-297469-26d8o1xk 88 5 cytokines cytokine NNS cord-297469-26d8o1xk 88 6 ( ( -LRB- cord-297469-26d8o1xk 88 7 interferon interferon NN cord-297469-26d8o1xk 88 8 - - HYPH cord-297469-26d8o1xk 88 9 β β NNP cord-297469-26d8o1xk 88 10 , , , cord-297469-26d8o1xk 88 11 granulocyte granulocyte NNP cord-297469-26d8o1xk 88 12 macrophage macrophage NN cord-297469-26d8o1xk 88 13 colony colony NN cord-297469-26d8o1xk 88 14 stimulating stimulate VBG cord-297469-26d8o1xk 88 15 factor factor NN cord-297469-26d8o1xk 88 16 ( ( -LRB- cord-297469-26d8o1xk 88 17 GM GM NNP cord-297469-26d8o1xk 88 18 - - HYPH cord-297469-26d8o1xk 88 19 CSF CSF NNP cord-297469-26d8o1xk 88 20 ) ) -RRB- cord-297469-26d8o1xk 88 21 , , , cord-297469-26d8o1xk 88 22 transforming transform VBG cord-297469-26d8o1xk 88 23 growth growth NN cord-297469-26d8o1xk 88 24 factor factor NN cord-297469-26d8o1xk 88 25 beta beta NN cord-297469-26d8o1xk 88 26 1 1 CD cord-297469-26d8o1xk 88 27 ( ( -LRB- cord-297469-26d8o1xk 88 28 TGF TGF NNP cord-297469-26d8o1xk 88 29 - - HYPH cord-297469-26d8o1xk 88 30 β1 β1 NNP cord-297469-26d8o1xk 88 31 ) ) -RRB- cord-297469-26d8o1xk 88 32 , , , cord-297469-26d8o1xk 88 33 and and CC cord-297469-26d8o1xk 88 34 tumor tumor NN cord-297469-26d8o1xk 88 35 necrosis necrosis NN cord-297469-26d8o1xk 88 36 factor factor NN cord-297469-26d8o1xk 88 37 alpha alpha NN cord-297469-26d8o1xk 88 38 ( ( -LRB- cord-297469-26d8o1xk 88 39 TNF TNF NNP cord-297469-26d8o1xk 88 40 - - HYPH cord-297469-26d8o1xk 88 41 α α NNP cord-297469-26d8o1xk 88 42 ) ) -RRB- cord-297469-26d8o1xk 88 43 ) ) -RRB- cord-297469-26d8o1xk 88 44 in in IN cord-297469-26d8o1xk 88 45 T. T. NNP cord-297469-26d8o1xk 88 46 gondii gondii NN cord-297469-26d8o1xk 88 47 - - HYPH cord-297469-26d8o1xk 88 48 infected infect VBN cord-297469-26d8o1xk 88 49 immune immune JJ cord-297469-26d8o1xk 88 50 cells cell NNS cord-297469-26d8o1xk 88 51 was be VBD cord-297469-26d8o1xk 88 52 notably notably RB cord-297469-26d8o1xk 88 53 changed change VBN cord-297469-26d8o1xk 88 54 in in IN cord-297469-26d8o1xk 88 55 a a DT cord-297469-26d8o1xk 88 56 concentration concentration NN cord-297469-26d8o1xk 88 57 - - HYPH cord-297469-26d8o1xk 88 58 dependent dependent JJ cord-297469-26d8o1xk 88 59 manner manner NN cord-297469-26d8o1xk 88 60 when when WRB cord-297469-26d8o1xk 88 61 the the DT cord-297469-26d8o1xk 88 62 cells cell NNS cord-297469-26d8o1xk 88 63 were be VBD cord-297469-26d8o1xk 88 64 incubated incubate VBN cord-297469-26d8o1xk 88 65 with with IN cord-297469-26d8o1xk 88 66 different different JJ cord-297469-26d8o1xk 88 67 concentrations concentration NNS cord-297469-26d8o1xk 88 68 ( ( -LRB- cord-297469-26d8o1xk 88 69 25 25 CD cord-297469-26d8o1xk 88 70 - - SYM cord-297469-26d8o1xk 88 71 100 100 CD cord-297469-26d8o1xk 88 72 µg µg NN cord-297469-26d8o1xk 88 73 / / SYM cord-297469-26d8o1xk 88 74 mL ml NN cord-297469-26d8o1xk 88 75 ) ) -RRB- cord-297469-26d8o1xk 88 76 of of IN cord-297469-26d8o1xk 88 77 UA UA NNP cord-297469-26d8o1xk 88 78 , , , cord-297469-26d8o1xk 88 79 and and CC cord-297469-26d8o1xk 88 80 their -PRON- PRP$ cord-297469-26d8o1xk 88 81 changes change NNS cord-297469-26d8o1xk 88 82 were be VBD cord-297469-26d8o1xk 88 83 measured measure VBN cord-297469-26d8o1xk 88 84 under under IN cord-297469-26d8o1xk 88 85 an an DT cord-297469-26d8o1xk 88 86 ELISA ELISA NNP cord-297469-26d8o1xk 88 87 reader reader NN cord-297469-26d8o1xk 88 88 . . . cord-297469-26d8o1xk 89 1 In in IN cord-297469-26d8o1xk 89 2 particular particular JJ cord-297469-26d8o1xk 89 3 , , , cord-297469-26d8o1xk 89 4 the the DT cord-297469-26d8o1xk 89 5 production production NN cord-297469-26d8o1xk 89 6 of of IN cord-297469-26d8o1xk 89 7 interferon interferon NN cord-297469-26d8o1xk 89 8 - - HYPH cord-297469-26d8o1xk 89 9 β β NN cord-297469-26d8o1xk 89 10 and and CC cord-297469-26d8o1xk 89 11 GM GM NNP cord-297469-26d8o1xk 89 12 - - HYPH cord-297469-26d8o1xk 89 13 CSF CSF NNP cord-297469-26d8o1xk 89 14 was be VBD cord-297469-26d8o1xk 89 15 effectively effectively RB cord-297469-26d8o1xk 89 16 increased increase VBN cord-297469-26d8o1xk 89 17 in in IN cord-297469-26d8o1xk 89 18 T. T. NNP cord-297469-26d8o1xk 89 19 gondii gondii NN cord-297469-26d8o1xk 89 20 - - HYPH cord-297469-26d8o1xk 89 21 infected infect VBN cord-297469-26d8o1xk 89 22 cells cell NNS cord-297469-26d8o1xk 89 23 treated treat VBN cord-297469-26d8o1xk 89 24 with with IN cord-297469-26d8o1xk 89 25 UA UA NNP cord-297469-26d8o1xk 89 26 compared compare VBN cord-297469-26d8o1xk 89 27 with with IN cord-297469-26d8o1xk 89 28 T. T. NNP cord-297469-26d8o1xk 89 29 gondii gondii NN cord-297469-26d8o1xk 89 30 - - HYPH cord-297469-26d8o1xk 89 31 infected infect VBN cord-297469-26d8o1xk 89 32 cells cell NNS cord-297469-26d8o1xk 89 33 , , , cord-297469-26d8o1xk 89 34 and and CC cord-297469-26d8o1xk 89 35 these these DT cord-297469-26d8o1xk 89 36 changes change NNS cord-297469-26d8o1xk 89 37 show show VBP cord-297469-26d8o1xk 89 38 that that IN cord-297469-26d8o1xk 89 39 UA UA NNP cord-297469-26d8o1xk 89 40 accelerated accelerate VBD cord-297469-26d8o1xk 89 41 the the DT cord-297469-26d8o1xk 89 42 production production NN cord-297469-26d8o1xk 89 43 and and CC cord-297469-26d8o1xk 89 44 release release NN cord-297469-26d8o1xk 89 45 of of IN cord-297469-26d8o1xk 89 46 interferon interferon NN cord-297469-26d8o1xk 89 47 - - HYPH cord-297469-26d8o1xk 89 48 β β NN cord-297469-26d8o1xk 89 49 and and CC cord-297469-26d8o1xk 89 50 GM GM NNP cord-297469-26d8o1xk 89 51 - - HYPH cord-297469-26d8o1xk 89 52 CSF CSF NNP cord-297469-26d8o1xk 89 53 by by IN cord-297469-26d8o1xk 89 54 stimulating stimulate VBG cord-297469-26d8o1xk 89 55 the the DT cord-297469-26d8o1xk 89 56 macrophage macrophage NN cord-297469-26d8o1xk 89 57 , , , cord-297469-26d8o1xk 89 58 B b NN cord-297469-26d8o1xk 89 59 cells cell NNS cord-297469-26d8o1xk 89 60 , , , cord-297469-26d8o1xk 89 61 and and CC cord-297469-26d8o1xk 89 62 basophil basophil NNP cord-297469-26d8o1xk 89 63 cells cell NNS cord-297469-26d8o1xk 89 64 ( ( -LRB- cord-297469-26d8o1xk 89 65 Figure Figure NNP cord-297469-26d8o1xk 89 66 6 6 CD cord-297469-26d8o1xk 89 67 ) ) -RRB- cord-297469-26d8o1xk 89 68 . . . cord-297469-26d8o1xk 90 1 Moreover moreover RB cord-297469-26d8o1xk 90 2 , , , cord-297469-26d8o1xk 90 3 the the DT cord-297469-26d8o1xk 90 4 production production NN cord-297469-26d8o1xk 90 5 of of IN cord-297469-26d8o1xk 90 6 interferon interferon NN cord-297469-26d8o1xk 90 7 - - HYPH cord-297469-26d8o1xk 90 8 β β NNP cord-297469-26d8o1xk 90 9 was be VBD cord-297469-26d8o1xk 90 10 not not RB cord-297469-26d8o1xk 90 11 changed change VBN cord-297469-26d8o1xk 90 12 in in IN cord-297469-26d8o1xk 90 13 SF SF NNP cord-297469-26d8o1xk 90 14 - - HYPH cord-297469-26d8o1xk 90 15 treated treat VBN cord-297469-26d8o1xk 90 16 groups group NNS cord-297469-26d8o1xk 90 17 , , , cord-297469-26d8o1xk 90 18 and and CC cord-297469-26d8o1xk 90 19 the the DT cord-297469-26d8o1xk 90 20 production production NN cord-297469-26d8o1xk 90 21 of of IN cord-297469-26d8o1xk 90 22 GM GM NNP cord-297469-26d8o1xk 90 23 - - HYPH cord-297469-26d8o1xk 90 24 CSF CSF NNP cord-297469-26d8o1xk 90 25 was be VBD cord-297469-26d8o1xk 90 26 gradually gradually RB cord-297469-26d8o1xk 90 27 decreased decrease VBN cord-297469-26d8o1xk 90 28 . . . cord-297469-26d8o1xk 91 1 Furthermore furthermore RB cord-297469-26d8o1xk 91 2 , , , cord-297469-26d8o1xk 91 3 the the DT cord-297469-26d8o1xk 91 4 expression expression NN cord-297469-26d8o1xk 91 5 of of IN cord-297469-26d8o1xk 91 6 TGF TGF NNP cord-297469-26d8o1xk 91 7 - - HYPH cord-297469-26d8o1xk 91 8 β1 β1 NNP cord-297469-26d8o1xk 91 9 and and CC cord-297469-26d8o1xk 91 10 TNF TNF NNP cord-297469-26d8o1xk 91 11 - - HYPH cord-297469-26d8o1xk 91 12 α α NNP cord-297469-26d8o1xk 91 13 was be VBD cord-297469-26d8o1xk 91 14 markedly markedly RB cord-297469-26d8o1xk 91 15 reduced reduce VBN cord-297469-26d8o1xk 91 16 in in IN cord-297469-26d8o1xk 91 17 T. T. NNP cord-297469-26d8o1xk 91 18 gondii gondii NN cord-297469-26d8o1xk 91 19 - - HYPH cord-297469-26d8o1xk 91 20 infected infect VBN cord-297469-26d8o1xk 91 21 cells cell NNS cord-297469-26d8o1xk 91 22 treated treat VBN cord-297469-26d8o1xk 91 23 with with IN cord-297469-26d8o1xk 91 24 UA UA NNP cord-297469-26d8o1xk 91 25 , , , cord-297469-26d8o1xk 91 26 whereas whereas IN cord-297469-26d8o1xk 91 27 T. T. NNP cord-297469-26d8o1xk 91 28 gondii gondii NN cord-297469-26d8o1xk 91 29 - - HYPH cord-297469-26d8o1xk 91 30 infected infect VBN cord-297469-26d8o1xk 91 31 cells cell NNS cord-297469-26d8o1xk 91 32 treated treat VBN cord-297469-26d8o1xk 91 33 with with IN cord-297469-26d8o1xk 91 34 SF SF NNP cord-297469-26d8o1xk 91 35 did do VBD cord-297469-26d8o1xk 91 36 not not RB cord-297469-26d8o1xk 91 37 cause cause VB cord-297469-26d8o1xk 91 38 the the DT cord-297469-26d8o1xk 91 39 production production NN cord-297469-26d8o1xk 91 40 of of IN cord-297469-26d8o1xk 91 41 TGF TGF NNP cord-297469-26d8o1xk 91 42 - - HYPH cord-297469-26d8o1xk 91 43 β1 β1 NNP cord-297469-26d8o1xk 91 44 and and CC cord-297469-26d8o1xk 91 45 TNF TNF NNP cord-297469-26d8o1xk 91 46 - - HYPH cord-297469-26d8o1xk 91 47 α α NN cord-297469-26d8o1xk 91 48 compared compare VBN cord-297469-26d8o1xk 91 49 with with IN cord-297469-26d8o1xk 91 50 other other JJ cord-297469-26d8o1xk 91 51 groups group NNS cord-297469-26d8o1xk 91 52 ( ( -LRB- cord-297469-26d8o1xk 91 53 Figure Figure NNP cord-297469-26d8o1xk 91 54 7 7 CD cord-297469-26d8o1xk 91 55 ) ) -RRB- cord-297469-26d8o1xk 91 56 . . . cord-297469-26d8o1xk 92 1 Interestingly interestingly RB cord-297469-26d8o1xk 92 2 , , , cord-297469-26d8o1xk 92 3 T. T. NNP cord-297469-26d8o1xk 92 4 gondii gondii NN cord-297469-26d8o1xk 92 5 - - HYPH cord-297469-26d8o1xk 92 6 infected infect VBN cord-297469-26d8o1xk 92 7 cells cell NNS cord-297469-26d8o1xk 92 8 treated treat VBN cord-297469-26d8o1xk 92 9 with with IN cord-297469-26d8o1xk 92 10 SF SF NNP cord-297469-26d8o1xk 92 11 did do VBD cord-297469-26d8o1xk 92 12 not not RB cord-297469-26d8o1xk 92 13 significantly significantly RB cord-297469-26d8o1xk 92 14 produce produce VB cord-297469-26d8o1xk 92 15 the the DT cord-297469-26d8o1xk 92 16 expression expression NN cord-297469-26d8o1xk 92 17 of of IN cord-297469-26d8o1xk 92 18 Interferon Interferon NNP cord-297469-26d8o1xk 92 19 - - HYPH cord-297469-26d8o1xk 92 20 β β NNP cord-297469-26d8o1xk 92 21 , , , cord-297469-26d8o1xk 92 22 TGF TGF NNP cord-297469-26d8o1xk 92 23 - - HYPH cord-297469-26d8o1xk 92 24 β1 β1 NNP cord-297469-26d8o1xk 92 25 and and CC cord-297469-26d8o1xk 92 26 TNF TNF NNP cord-297469-26d8o1xk 92 27 - - HYPH cord-297469-26d8o1xk 92 28 α α NNP cord-297469-26d8o1xk 92 29 compared compare VBN cord-297469-26d8o1xk 92 30 to to IN cord-297469-26d8o1xk 92 31 the the DT cord-297469-26d8o1xk 92 32 infected infected JJ cord-297469-26d8o1xk 92 33 group group NN cord-297469-26d8o1xk 92 34 . . . cord-297469-26d8o1xk 93 1 This this DT cord-297469-26d8o1xk 93 2 shows show VBZ cord-297469-26d8o1xk 93 3 that that IN cord-297469-26d8o1xk 93 4 SF SF NNP cord-297469-26d8o1xk 93 5 is be VBZ cord-297469-26d8o1xk 93 6 not not RB cord-297469-26d8o1xk 93 7 involved involve VBN cord-297469-26d8o1xk 93 8 in in IN cord-297469-26d8o1xk 93 9 immune immune JJ cord-297469-26d8o1xk 93 10 response response NN cord-297469-26d8o1xk 93 11 for for IN cord-297469-26d8o1xk 93 12 expressing express VBG cord-297469-26d8o1xk 93 13 TNF TNF NNP cord-297469-26d8o1xk 93 14 - - HYPH cord-297469-26d8o1xk 93 15 α α NNP cord-297469-26d8o1xk 93 16 , , , cord-297469-26d8o1xk 93 17 TGF TGF NNP cord-297469-26d8o1xk 93 18 - - HYPH cord-297469-26d8o1xk 93 19 β1 β1 NNP cord-297469-26d8o1xk 93 20 , , , cord-297469-26d8o1xk 93 21 and and CC cord-297469-26d8o1xk 93 22 interferon interferon NN cord-297469-26d8o1xk 93 23 - - HYPH cord-297469-26d8o1xk 93 24 β β NN cord-297469-26d8o1xk 93 25 in in IN cord-297469-26d8o1xk 93 26 immune immune JJ cord-297469-26d8o1xk 93 27 cells cell NNS cord-297469-26d8o1xk 93 28 . . . cord-297469-26d8o1xk 94 1 Furthermore furthermore RB cord-297469-26d8o1xk 94 2 , , , cord-297469-26d8o1xk 94 3 the the DT cord-297469-26d8o1xk 94 4 production production NN cord-297469-26d8o1xk 94 5 of of IN cord-297469-26d8o1xk 94 6 TGF TGF NNP cord-297469-26d8o1xk 94 7 - - HYPH cord-297469-26d8o1xk 94 8 β1 β1 NNP cord-297469-26d8o1xk 94 9 was be VBD cord-297469-26d8o1xk 94 10 decreased decrease VBN cord-297469-26d8o1xk 94 11 in in IN cord-297469-26d8o1xk 94 12 T. T. NNP cord-297469-26d8o1xk 94 13 gondii gondii NN cord-297469-26d8o1xk 94 14 - - HYPH cord-297469-26d8o1xk 94 15 infected infect VBN cord-297469-26d8o1xk 94 16 cells cell NNS cord-297469-26d8o1xk 94 17 treated treat VBN cord-297469-26d8o1xk 94 18 with with IN cord-297469-26d8o1xk 94 19 UA UA NNP cord-297469-26d8o1xk 94 20 , , , cord-297469-26d8o1xk 94 21 but but CC cord-297469-26d8o1xk 94 22 the the DT cord-297469-26d8o1xk 94 23 result result NN cord-297469-26d8o1xk 94 24 shows show VBZ cord-297469-26d8o1xk 94 25 that that IN cord-297469-26d8o1xk 94 26 UA UA NNP cord-297469-26d8o1xk 94 27 reduced reduce VBD cord-297469-26d8o1xk 94 28 the the DT cord-297469-26d8o1xk 94 29 expression expression NN cord-297469-26d8o1xk 94 30 of of IN cord-297469-26d8o1xk 94 31 TGF TGF NNP cord-297469-26d8o1xk 94 32 - - HYPH cord-297469-26d8o1xk 94 33 β1 β1 NNP cord-297469-26d8o1xk 94 34 in in IN cord-297469-26d8o1xk 94 35 immune immune JJ cord-297469-26d8o1xk 94 36 cells cell NNS cord-297469-26d8o1xk 94 37 by by IN cord-297469-26d8o1xk 94 38 directly directly RB cord-297469-26d8o1xk 94 39 inhibiting inhibit VBG cord-297469-26d8o1xk 94 40 T. t. NN cord-297469-26d8o1xk 94 41 gondii gondii NN cord-297469-26d8o1xk 94 42 . . . cord-297469-26d8o1xk 95 1 These these DT cord-297469-26d8o1xk 95 2 results result NNS cord-297469-26d8o1xk 95 3 demonstrate demonstrate VBP cord-297469-26d8o1xk 95 4 that that IN cord-297469-26d8o1xk 95 5 UA UA NNP cord-297469-26d8o1xk 95 6 not not RB cord-297469-26d8o1xk 95 7 only only RB cord-297469-26d8o1xk 95 8 promotes promote VBZ cord-297469-26d8o1xk 95 9 defense defense NN cord-297469-26d8o1xk 95 10 against against IN cord-297469-26d8o1xk 95 11 parasitic parasitic JJ cord-297469-26d8o1xk 95 12 infection infection NN cord-297469-26d8o1xk 95 13 by by IN cord-297469-26d8o1xk 95 14 effectively effectively RB cord-297469-26d8o1xk 95 15 inducing induce VBG cord-297469-26d8o1xk 95 16 the the DT cord-297469-26d8o1xk 95 17 production production NN cord-297469-26d8o1xk 95 18 of of IN cord-297469-26d8o1xk 95 19 Interferon Interferon NNP cord-297469-26d8o1xk 95 20 - - HYPH cord-297469-26d8o1xk 95 21 β β NNP cord-297469-26d8o1xk 95 22 and and CC cord-297469-26d8o1xk 95 23 GM GM NNP cord-297469-26d8o1xk 95 24 - - HYPH cord-297469-26d8o1xk 95 25 CSF CSF NNP cord-297469-26d8o1xk 95 26 from from IN cord-297469-26d8o1xk 95 27 immune immune JJ cord-297469-26d8o1xk 95 28 cells cell NNS cord-297469-26d8o1xk 95 29 when when WRB cord-297469-26d8o1xk 95 30 the the DT cord-297469-26d8o1xk 95 31 cells cell NNS cord-297469-26d8o1xk 95 32 are be VBP cord-297469-26d8o1xk 95 33 infected infect VBN cord-297469-26d8o1xk 95 34 with with IN cord-297469-26d8o1xk 95 35 T. t. NN cord-297469-26d8o1xk 95 36 gondii gondii NN cord-297469-26d8o1xk 95 37 , , , cord-297469-26d8o1xk 95 38 but but CC cord-297469-26d8o1xk 95 39 also also RB cord-297469-26d8o1xk 95 40 inhibits inhibit VBZ cord-297469-26d8o1xk 95 41 the the DT cord-297469-26d8o1xk 95 42 overexpression overexpression NN cord-297469-26d8o1xk 95 43 of of IN cord-297469-26d8o1xk 95 44 inflammatory inflammatory JJ cord-297469-26d8o1xk 95 45 cytokine cytokine NN cord-297469-26d8o1xk 95 46 by by IN cord-297469-26d8o1xk 95 47 reducing reduce VBG cord-297469-26d8o1xk 95 48 the the DT cord-297469-26d8o1xk 95 49 expression expression NN cord-297469-26d8o1xk 95 50 of of IN cord-297469-26d8o1xk 95 51 TNF TNF NNP cord-297469-26d8o1xk 95 52 - - HYPH cord-297469-26d8o1xk 95 53 α α NNP cord-297469-26d8o1xk 95 54 caused cause VBN cord-297469-26d8o1xk 95 55 by by IN cord-297469-26d8o1xk 95 56 infection infection NN cord-297469-26d8o1xk 95 57 . . . cord-297469-26d8o1xk 95 58 _SP cord-297469-26d8o1xk 96 1 We -PRON- PRP cord-297469-26d8o1xk 96 2 evaluated evaluate VBD cord-297469-26d8o1xk 96 3 the the DT cord-297469-26d8o1xk 96 4 activation activation NN cord-297469-26d8o1xk 96 5 and and CC cord-297469-26d8o1xk 96 6 interaction interaction NN cord-297469-26d8o1xk 96 7 of of IN cord-297469-26d8o1xk 96 8 various various JJ cord-297469-26d8o1xk 96 9 cytokines cytokine NNS cord-297469-26d8o1xk 96 10 induced induce VBN cord-297469-26d8o1xk 96 11 by by IN cord-297469-26d8o1xk 96 12 ursolic ursolic JJ cord-297469-26d8o1xk 96 13 acid acid NNP cord-297469-26d8o1xk 96 14 through through IN cord-297469-26d8o1xk 96 15 co co JJ cord-297469-26d8o1xk 96 16 - - JJ cord-297469-26d8o1xk 96 17 cultured cultured JJ cord-297469-26d8o1xk 96 18 immune immune JJ cord-297469-26d8o1xk 96 19 cells cell NNS cord-297469-26d8o1xk 96 20 ( ( -LRB- cord-297469-26d8o1xk 96 21 macrophage macrophage NN cord-297469-26d8o1xk 96 22 , , , cord-297469-26d8o1xk 96 23 T t NN cord-297469-26d8o1xk 96 24 cells cell NNS cord-297469-26d8o1xk 96 25 , , , cord-297469-26d8o1xk 96 26 B b NN cord-297469-26d8o1xk 96 27 cells cell NNS cord-297469-26d8o1xk 96 28 and and CC cord-297469-26d8o1xk 96 29 basophil basophil NNP cord-297469-26d8o1xk 96 30 cells cell NNS cord-297469-26d8o1xk 96 31 ) ) -RRB- cord-297469-26d8o1xk 96 32 infected infect VBN cord-297469-26d8o1xk 96 33 with with IN cord-297469-26d8o1xk 96 34 T. t. NN cord-297469-26d8o1xk 96 35 gondii gondii NNP cord-297469-26d8o1xk 96 36 . . . cord-297469-26d8o1xk 97 1 The the DT cord-297469-26d8o1xk 97 2 changes change NNS cord-297469-26d8o1xk 97 3 of of IN cord-297469-26d8o1xk 97 4 the the DT cord-297469-26d8o1xk 97 5 cytokines cytokine NNS cord-297469-26d8o1xk 97 6 ( ( -LRB- cord-297469-26d8o1xk 97 7 interleukin interleukin NN cord-297469-26d8o1xk 97 8 ( ( -LRB- cord-297469-26d8o1xk 97 9 IL)-1β IL)-1β NNP cord-297469-26d8o1xk 97 10 , , , cord-297469-26d8o1xk 97 11 IL-6 IL-6 NNP cord-297469-26d8o1xk 97 12 , , , cord-297469-26d8o1xk 97 13 IL-10 IL-10 NNP cord-297469-26d8o1xk 97 14 , , , cord-297469-26d8o1xk 97 15 and and CC cord-297469-26d8o1xk 97 16 IL-12 IL-12 NNP cord-297469-26d8o1xk 97 17 ) ) -RRB- cord-297469-26d8o1xk 97 18 in in IN cord-297469-26d8o1xk 97 19 T. T. NNP cord-297469-26d8o1xk 97 20 gondii gondii NN cord-297469-26d8o1xk 97 21 - - HYPH cord-297469-26d8o1xk 97 22 infected infect VBN cord-297469-26d8o1xk 97 23 immune immune JJ cord-297469-26d8o1xk 97 24 cells cell NNS cord-297469-26d8o1xk 97 25 were be VBD cord-297469-26d8o1xk 97 26 measured measure VBN cord-297469-26d8o1xk 97 27 in in IN cord-297469-26d8o1xk 97 28 a a DT cord-297469-26d8o1xk 97 29 dose dose NN cord-297469-26d8o1xk 97 30 - - HYPH cord-297469-26d8o1xk 97 31 dependent dependent JJ cord-297469-26d8o1xk 97 32 manner manner NN cord-297469-26d8o1xk 97 33 when when WRB cord-297469-26d8o1xk 97 34 the the DT cord-297469-26d8o1xk 97 35 cells cell NNS cord-297469-26d8o1xk 97 36 were be VBD cord-297469-26d8o1xk 97 37 incubated incubate VBN cord-297469-26d8o1xk 97 38 with with IN cord-297469-26d8o1xk 97 39 different different JJ cord-297469-26d8o1xk 97 40 concentrations concentration NNS cord-297469-26d8o1xk 97 41 ( ( -LRB- cord-297469-26d8o1xk 97 42 25 25 CD cord-297469-26d8o1xk 97 43 - - SYM cord-297469-26d8o1xk 97 44 100 100 CD cord-297469-26d8o1xk 97 45 μg μg NNP cord-297469-26d8o1xk 97 46 / / SYM cord-297469-26d8o1xk 97 47 mL mL NNP cord-297469-26d8o1xk 97 48 ) ) -RRB- cord-297469-26d8o1xk 97 49 of of IN cord-297469-26d8o1xk 97 50 UA UA NNP cord-297469-26d8o1xk 97 51 , , , cord-297469-26d8o1xk 97 52 and and CC cord-297469-26d8o1xk 97 53 their -PRON- PRP$ cord-297469-26d8o1xk 97 54 changes change NNS cord-297469-26d8o1xk 97 55 were be VBD cord-297469-26d8o1xk 97 56 evaluated evaluate VBN cord-297469-26d8o1xk 97 57 under under IN cord-297469-26d8o1xk 97 58 an an DT cord-297469-26d8o1xk 97 59 ELISA ELISA NNP cord-297469-26d8o1xk 97 60 reader reader NN cord-297469-26d8o1xk 97 61 . . . cord-297469-26d8o1xk 98 1 In in IN cord-297469-26d8o1xk 98 2 particular particular JJ cord-297469-26d8o1xk 98 3 , , , cord-297469-26d8o1xk 98 4 the the DT cord-297469-26d8o1xk 98 5 production production NN cord-297469-26d8o1xk 98 6 of of IN cord-297469-26d8o1xk 98 7 IL-1β IL-1β NNP cord-297469-26d8o1xk 98 8 and and CC cord-297469-26d8o1xk 98 9 IL-6 IL-6 NNP cord-297469-26d8o1xk 98 10 was be VBD cord-297469-26d8o1xk 98 11 reduced reduce VBN cord-297469-26d8o1xk 98 12 in in IN cord-297469-26d8o1xk 98 13 the the DT cord-297469-26d8o1xk 98 14 groups group NNS cord-297469-26d8o1xk 98 15 treated treat VBN cord-297469-26d8o1xk 98 16 with with IN cord-297469-26d8o1xk 98 17 UA UA NNP cord-297469-26d8o1xk 98 18 compared compare VBN cord-297469-26d8o1xk 98 19 with with IN cord-297469-26d8o1xk 98 20 the the DT cord-297469-26d8o1xk 98 21 infection infection NN cord-297469-26d8o1xk 98 22 group group NN cord-297469-26d8o1xk 98 23 , , , cord-297469-26d8o1xk 98 24 and and CC cord-297469-26d8o1xk 98 25 the the DT cord-297469-26d8o1xk 98 26 expression expression NN cord-297469-26d8o1xk 98 27 of of IN cord-297469-26d8o1xk 98 28 IL-10 IL-10 NNP cord-297469-26d8o1xk 98 29 and and CC cord-297469-26d8o1xk 98 30 IL-12 IL-12 NNP cord-297469-26d8o1xk 98 31 was be VBD cord-297469-26d8o1xk 98 32 significantly significantly RB cord-297469-26d8o1xk 98 33 increased increase VBN cord-297469-26d8o1xk 98 34 in in IN cord-297469-26d8o1xk 98 35 T. T. NNP cord-297469-26d8o1xk 98 36 _SP cord-297469-26d8o1xk 99 1 The the DT cord-297469-26d8o1xk 99 2 changes change NNS cord-297469-26d8o1xk 99 3 of of IN cord-297469-26d8o1xk 99 4 the the DT cord-297469-26d8o1xk 99 5 cytokines cytokine NNS cord-297469-26d8o1xk 99 6 ( ( -LRB- cord-297469-26d8o1xk 99 7 interleukin interleukin NN cord-297469-26d8o1xk 99 8 ( ( -LRB- cord-297469-26d8o1xk 99 9 IL)-1β IL)-1β NNP cord-297469-26d8o1xk 99 10 , , , cord-297469-26d8o1xk 99 11 IL-6 IL-6 NNP cord-297469-26d8o1xk 99 12 , , , cord-297469-26d8o1xk 99 13 IL-10 IL-10 NNP cord-297469-26d8o1xk 99 14 , , , cord-297469-26d8o1xk 99 15 and and CC cord-297469-26d8o1xk 99 16 IL-12 IL-12 NNP cord-297469-26d8o1xk 99 17 ) ) -RRB- cord-297469-26d8o1xk 99 18 in in IN cord-297469-26d8o1xk 99 19 T. T. NNP cord-297469-26d8o1xk 99 20 gondii gondii NN cord-297469-26d8o1xk 99 21 - - HYPH cord-297469-26d8o1xk 99 22 infected infect VBN cord-297469-26d8o1xk 99 23 immune immune JJ cord-297469-26d8o1xk 99 24 cells cell NNS cord-297469-26d8o1xk 99 25 were be VBD cord-297469-26d8o1xk 99 26 measured measure VBN cord-297469-26d8o1xk 99 27 in in IN cord-297469-26d8o1xk 99 28 a a DT cord-297469-26d8o1xk 99 29 dose dose NN cord-297469-26d8o1xk 99 30 - - HYPH cord-297469-26d8o1xk 99 31 dependent dependent JJ cord-297469-26d8o1xk 99 32 manner manner NN cord-297469-26d8o1xk 99 33 when when WRB cord-297469-26d8o1xk 99 34 the the DT cord-297469-26d8o1xk 99 35 cells cell NNS cord-297469-26d8o1xk 99 36 were be VBD cord-297469-26d8o1xk 99 37 incubated incubate VBN cord-297469-26d8o1xk 99 38 with with IN cord-297469-26d8o1xk 99 39 different different JJ cord-297469-26d8o1xk 99 40 concentrations concentration NNS cord-297469-26d8o1xk 99 41 ( ( -LRB- cord-297469-26d8o1xk 99 42 25 25 CD cord-297469-26d8o1xk 99 43 - - SYM cord-297469-26d8o1xk 99 44 100 100 CD cord-297469-26d8o1xk 99 45 µg µg NN cord-297469-26d8o1xk 99 46 / / SYM cord-297469-26d8o1xk 99 47 mL ml NN cord-297469-26d8o1xk 99 48 ) ) -RRB- cord-297469-26d8o1xk 99 49 of of IN cord-297469-26d8o1xk 99 50 UA UA NNP cord-297469-26d8o1xk 99 51 , , , cord-297469-26d8o1xk 99 52 and and CC cord-297469-26d8o1xk 99 53 their -PRON- PRP$ cord-297469-26d8o1xk 99 54 changes change NNS cord-297469-26d8o1xk 99 55 were be VBD cord-297469-26d8o1xk 99 56 evaluated evaluate VBN cord-297469-26d8o1xk 99 57 under under IN cord-297469-26d8o1xk 99 58 an an DT cord-297469-26d8o1xk 99 59 ELISA ELISA NNP cord-297469-26d8o1xk 99 60 reader reader NN cord-297469-26d8o1xk 99 61 . . . cord-297469-26d8o1xk 100 1 In in IN cord-297469-26d8o1xk 100 2 particular particular JJ cord-297469-26d8o1xk 100 3 , , , cord-297469-26d8o1xk 100 4 the the DT cord-297469-26d8o1xk 100 5 production production NN cord-297469-26d8o1xk 100 6 of of IN cord-297469-26d8o1xk 100 7 IL-1β IL-1β NNP cord-297469-26d8o1xk 100 8 and and CC cord-297469-26d8o1xk 100 9 IL-6 IL-6 NNP cord-297469-26d8o1xk 100 10 was be VBD cord-297469-26d8o1xk 100 11 reduced reduce VBN cord-297469-26d8o1xk 100 12 in in IN cord-297469-26d8o1xk 100 13 the the DT cord-297469-26d8o1xk 100 14 groups group NNS cord-297469-26d8o1xk 100 15 treated treat VBN cord-297469-26d8o1xk 100 16 with with IN cord-297469-26d8o1xk 100 17 UA UA NNP cord-297469-26d8o1xk 100 18 compared compare VBN cord-297469-26d8o1xk 100 19 with with IN cord-297469-26d8o1xk 100 20 the the DT cord-297469-26d8o1xk 100 21 infection infection NN cord-297469-26d8o1xk 100 22 group group NN cord-297469-26d8o1xk 100 23 , , , cord-297469-26d8o1xk 100 24 and and CC cord-297469-26d8o1xk 100 25 the the DT cord-297469-26d8o1xk 100 26 expression expression NN cord-297469-26d8o1xk 100 27 of of IN cord-297469-26d8o1xk 100 28 IL-10 IL-10 NNP cord-297469-26d8o1xk 100 29 and and CC cord-297469-26d8o1xk 100 30 IL-12 IL-12 NNP cord-297469-26d8o1xk 100 31 was be VBD cord-297469-26d8o1xk 100 32 significantly significantly RB cord-297469-26d8o1xk 100 33 increased increase VBN cord-297469-26d8o1xk 100 34 in in IN cord-297469-26d8o1xk 100 35 T. T. NNP cord-297469-26d8o1xk 100 36 gondii gondii NN cord-297469-26d8o1xk 100 37 - - HYPH cord-297469-26d8o1xk 100 38 infected infect VBN cord-297469-26d8o1xk 100 39 cells cell NNS cord-297469-26d8o1xk 100 40 treated treat VBN cord-297469-26d8o1xk 100 41 with with IN cord-297469-26d8o1xk 100 42 UA UA NNP cord-297469-26d8o1xk 100 43 ( ( -LRB- cord-297469-26d8o1xk 100 44 Figures figure NNS cord-297469-26d8o1xk 100 45 8 8 CD cord-297469-26d8o1xk 100 46 and and CC cord-297469-26d8o1xk 100 47 9 9 CD cord-297469-26d8o1xk 100 48 ) ) -RRB- cord-297469-26d8o1xk 100 49 . . . cord-297469-26d8o1xk 101 1 These these DT cord-297469-26d8o1xk 101 2 changes change NNS cord-297469-26d8o1xk 101 3 demonstrate demonstrate VBP cord-297469-26d8o1xk 101 4 that that IN cord-297469-26d8o1xk 101 5 UA UA NNP cord-297469-26d8o1xk 101 6 promotes promote VBZ cord-297469-26d8o1xk 101 7 the the DT cord-297469-26d8o1xk 101 8 production production NN cord-297469-26d8o1xk 101 9 and and CC cord-297469-26d8o1xk 101 10 the the DT cord-297469-26d8o1xk 101 11 expression expression NN cord-297469-26d8o1xk 101 12 of of IN cord-297469-26d8o1xk 101 13 IL-10 IL-10 NNP cord-297469-26d8o1xk 101 14 and and CC cord-297469-26d8o1xk 101 15 IL-12 IL-12 NNP cord-297469-26d8o1xk 101 16 by by IN cord-297469-26d8o1xk 101 17 consistently consistently RB cord-297469-26d8o1xk 101 18 stimulating stimulate VBG cord-297469-26d8o1xk 101 19 the the DT cord-297469-26d8o1xk 101 20 immune immune JJ cord-297469-26d8o1xk 101 21 cells cell NNS cord-297469-26d8o1xk 101 22 as as RB cord-297469-26d8o1xk 101 23 well well RB cord-297469-26d8o1xk 101 24 as as IN cord-297469-26d8o1xk 101 25 inhibit inhibit VB cord-297469-26d8o1xk 101 26 the the DT cord-297469-26d8o1xk 101 27 expressions expression NNS cord-297469-26d8o1xk 101 28 of of IN cord-297469-26d8o1xk 101 29 IL-1β IL-1β NNP cord-297469-26d8o1xk 101 30 and and CC cord-297469-26d8o1xk 101 31 IL-6 IL-6 NNP cord-297469-26d8o1xk 101 32 induced induce VBN cord-297469-26d8o1xk 101 33 by by IN cord-297469-26d8o1xk 101 34 T. T. NNP cord-297469-26d8o1xk 101 35 gondii gondii NNP cord-297469-26d8o1xk 101 36 infection infection NN cord-297469-26d8o1xk 101 37 . . . cord-297469-26d8o1xk 102 1 Interestingly interestingly RB cord-297469-26d8o1xk 102 2 , , , cord-297469-26d8o1xk 102 3 the the DT cord-297469-26d8o1xk 102 4 production production NN cord-297469-26d8o1xk 102 5 of of IN cord-297469-26d8o1xk 102 6 IL-1β il-1β NN cord-297469-26d8o1xk 102 7 in in IN cord-297469-26d8o1xk 102 8 T. T. NNP cord-297469-26d8o1xk 102 9 gondii gondii NN cord-297469-26d8o1xk 102 10 - - HYPH cord-297469-26d8o1xk 102 11 infected infect VBN cord-297469-26d8o1xk 102 12 cells cell NNS cord-297469-26d8o1xk 102 13 treated treat VBN cord-297469-26d8o1xk 102 14 with with IN cord-297469-26d8o1xk 102 15 SF SF NNP cord-297469-26d8o1xk 102 16 was be VBD cord-297469-26d8o1xk 102 17 significantly significantly RB cord-297469-26d8o1xk 102 18 increased increase VBN cord-297469-26d8o1xk 102 19 and and CC cord-297469-26d8o1xk 102 20 the the DT cord-297469-26d8o1xk 102 21 expression expression NN cord-297469-26d8o1xk 102 22 of of IN cord-297469-26d8o1xk 102 23 IL-10 IL-10 NNP cord-297469-26d8o1xk 102 24 was be VBD cord-297469-26d8o1xk 102 25 gradually gradually RB cord-297469-26d8o1xk 102 26 decreased decrease VBN cord-297469-26d8o1xk 102 27 compared compare VBN cord-297469-26d8o1xk 102 28 with with IN cord-297469-26d8o1xk 102 29 the the DT cord-297469-26d8o1xk 102 30 infection infection NN cord-297469-26d8o1xk 102 31 group group NN cord-297469-26d8o1xk 102 32 . . . cord-297469-26d8o1xk 103 1 However however RB cord-297469-26d8o1xk 103 2 , , , cord-297469-26d8o1xk 103 3 there there EX cord-297469-26d8o1xk 103 4 were be VBD cord-297469-26d8o1xk 103 5 no no DT cord-297469-26d8o1xk 103 6 significant significant JJ cord-297469-26d8o1xk 103 7 changes change NNS cord-297469-26d8o1xk 103 8 of of IN cord-297469-26d8o1xk 103 9 the the DT cord-297469-26d8o1xk 103 10 production production NN cord-297469-26d8o1xk 103 11 of of IN cord-297469-26d8o1xk 103 12 IL-6 IL-6 NNP cord-297469-26d8o1xk 103 13 and and CC cord-297469-26d8o1xk 103 14 IL-12 IL-12 NNP cord-297469-26d8o1xk 103 15 in in IN cord-297469-26d8o1xk 103 16 T. T. NNP cord-297469-26d8o1xk 103 17 gondii gondii NN cord-297469-26d8o1xk 103 18 - - HYPH cord-297469-26d8o1xk 103 19 infected infect VBN cord-297469-26d8o1xk 103 20 cells cell NNS cord-297469-26d8o1xk 103 21 treated treat VBN cord-297469-26d8o1xk 103 22 with with IN cord-297469-26d8o1xk 103 23 SF SF NNP cord-297469-26d8o1xk 103 24 . . . cord-297469-26d8o1xk 104 1 In in IN cord-297469-26d8o1xk 104 2 particular particular JJ cord-297469-26d8o1xk 104 3 , , , cord-297469-26d8o1xk 104 4 significant significant JJ cord-297469-26d8o1xk 104 5 differences difference NNS cord-297469-26d8o1xk 104 6 in in IN cord-297469-26d8o1xk 104 7 the the DT cord-297469-26d8o1xk 104 8 cytokines cytokine NNS cord-297469-26d8o1xk 104 9 were be VBD cord-297469-26d8o1xk 104 10 clearly clearly RB cord-297469-26d8o1xk 104 11 measured measure VBN cord-297469-26d8o1xk 104 12 between between IN cord-297469-26d8o1xk 104 13 the the DT cord-297469-26d8o1xk 104 14 T. T. NNP cord-297469-26d8o1xk 104 15 gondii gondii NN cord-297469-26d8o1xk 104 16 - - HYPH cord-297469-26d8o1xk 104 17 infected infect VBN cord-297469-26d8o1xk 104 18 group group NN cord-297469-26d8o1xk 104 19 and and CC cord-297469-26d8o1xk 104 20 UA UA NNP cord-297469-26d8o1xk 104 21 - - HYPH cord-297469-26d8o1xk 104 22 treated treat VBN cord-297469-26d8o1xk 104 23 group group NN cord-297469-26d8o1xk 104 24 , , , cord-297469-26d8o1xk 104 25 and and CC cord-297469-26d8o1xk 104 26 these these DT cord-297469-26d8o1xk 104 27 changes change NNS cord-297469-26d8o1xk 104 28 of of IN cord-297469-26d8o1xk 104 29 cytokines cytokine NNS cord-297469-26d8o1xk 104 30 were be VBD cord-297469-26d8o1xk 104 31 confirmed confirm VBN cord-297469-26d8o1xk 104 32 in in IN cord-297469-26d8o1xk 104 33 all all PDT cord-297469-26d8o1xk 104 34 the the DT cord-297469-26d8o1xk 104 35 groups group NNS cord-297469-26d8o1xk 104 36 . . . cord-297469-26d8o1xk 105 1 Furthermore furthermore RB cord-297469-26d8o1xk 105 2 , , , cord-297469-26d8o1xk 105 3 the the DT cord-297469-26d8o1xk 105 4 results result NNS cord-297469-26d8o1xk 105 5 show show VBP cord-297469-26d8o1xk 105 6 that that IN cord-297469-26d8o1xk 105 7 this this DT cord-297469-26d8o1xk 105 8 co co NN cord-297469-26d8o1xk 105 9 - - NN cord-297469-26d8o1xk 105 10 culture culture JJ cord-297469-26d8o1xk 105 11 system system NN cord-297469-26d8o1xk 105 12 through through IN cord-297469-26d8o1xk 105 13 immune immune JJ cord-297469-26d8o1xk 105 14 cells cell NNS cord-297469-26d8o1xk 105 15 can can MD cord-297469-26d8o1xk 105 16 be be VB cord-297469-26d8o1xk 105 17 usefully usefully RB cord-297469-26d8o1xk 105 18 utilized utilize VBN cord-297469-26d8o1xk 105 19 as as IN cord-297469-26d8o1xk 105 20 a a DT cord-297469-26d8o1xk 105 21 co co NN cord-297469-26d8o1xk 105 22 - - NN cord-297469-26d8o1xk 105 23 culture culture JJ cord-297469-26d8o1xk 105 24 method method NN cord-297469-26d8o1xk 105 25 for for IN cord-297469-26d8o1xk 105 26 measuring measure VBG cord-297469-26d8o1xk 105 27 various various JJ cord-297469-26d8o1xk 105 28 cytokines cytokine NNS cord-297469-26d8o1xk 105 29 , , , cord-297469-26d8o1xk 105 30 and and CC cord-297469-26d8o1xk 105 31 as as IN cord-297469-26d8o1xk 105 32 an an DT cord-297469-26d8o1xk 105 33 effective effective JJ cord-297469-26d8o1xk 105 34 alternative alternative NN cord-297469-26d8o1xk 105 35 to to IN cord-297469-26d8o1xk 105 36 in in IN cord-297469-26d8o1xk 105 37 vivo vivo NN cord-297469-26d8o1xk 105 38 experiments experiment NNS cord-297469-26d8o1xk 105 39 . . . cord-297469-26d8o1xk 106 1 These these DT cord-297469-26d8o1xk 106 2 results result NNS cord-297469-26d8o1xk 106 3 indicate indicate VBP cord-297469-26d8o1xk 106 4 that that IN cord-297469-26d8o1xk 106 5 UA UA NNP cord-297469-26d8o1xk 106 6 not not RB cord-297469-26d8o1xk 106 7 only only RB cord-297469-26d8o1xk 106 8 effectively effectively RB cord-297469-26d8o1xk 106 9 induces induce VBZ cord-297469-26d8o1xk 106 10 the the DT cord-297469-26d8o1xk 106 11 production production NN cord-297469-26d8o1xk 106 12 of of IN cord-297469-26d8o1xk 106 13 cytokines cytokine NNS cord-297469-26d8o1xk 106 14 between between IN cord-297469-26d8o1xk 106 15 the the DT cord-297469-26d8o1xk 106 16 immune immune JJ cord-297469-26d8o1xk 106 17 cells cell NNS cord-297469-26d8o1xk 106 18 by by IN cord-297469-26d8o1xk 106 19 increasing increase VBG cord-297469-26d8o1xk 106 20 the the DT cord-297469-26d8o1xk 106 21 expression expression NN cord-297469-26d8o1xk 106 22 of of IN cord-297469-26d8o1xk 106 23 IL-10 IL-10 NNP cord-297469-26d8o1xk 106 24 and and CC cord-297469-26d8o1xk 106 25 IL-12 IL-12 NNP cord-297469-26d8o1xk 106 26 in in IN cord-297469-26d8o1xk 106 27 macrophage macrophage NN cord-297469-26d8o1xk 106 28 and and CC cord-297469-26d8o1xk 106 29 B b NN cord-297469-26d8o1xk 106 30 cells cell NNS cord-297469-26d8o1xk 106 31 after after IN cord-297469-26d8o1xk 106 32 T. t. NN cord-297469-26d8o1xk 106 33 gondii gondii NN cord-297469-26d8o1xk 106 34 infection infection NN cord-297469-26d8o1xk 106 35 , , , cord-297469-26d8o1xk 106 36 but but CC cord-297469-26d8o1xk 106 37 also also RB cord-297469-26d8o1xk 106 38 suppresses suppress VBZ cord-297469-26d8o1xk 106 39 or or CC cord-297469-26d8o1xk 106 40 strongly strongly RB cord-297469-26d8o1xk 106 41 reduces reduce VBZ cord-297469-26d8o1xk 106 42 the the DT cord-297469-26d8o1xk 106 43 expression expression NN cord-297469-26d8o1xk 106 44 of of IN cord-297469-26d8o1xk 106 45 the the DT cord-297469-26d8o1xk 106 46 inflammatory inflammatory JJ cord-297469-26d8o1xk 106 47 cytokines cytokine NNS cord-297469-26d8o1xk 106 48 from from IN cord-297469-26d8o1xk 106 49 the the DT cord-297469-26d8o1xk 106 50 immune immune JJ cord-297469-26d8o1xk 106 51 cells cell NNS cord-297469-26d8o1xk 106 52 . . . cord-297469-26d8o1xk 107 1 gondii gondii NNP cord-297469-26d8o1xk 107 2 - - HYPH cord-297469-26d8o1xk 107 3 infected infect VBN cord-297469-26d8o1xk 107 4 cells cell NNS cord-297469-26d8o1xk 107 5 treated treat VBN cord-297469-26d8o1xk 107 6 with with IN cord-297469-26d8o1xk 107 7 UA UA NNP cord-297469-26d8o1xk 107 8 ( ( -LRB- cord-297469-26d8o1xk 107 9 Figure Figure NNP cord-297469-26d8o1xk 107 10 8 8 CD cord-297469-26d8o1xk 107 11 and and CC cord-297469-26d8o1xk 107 12 9 9 CD cord-297469-26d8o1xk 107 13 ) ) -RRB- cord-297469-26d8o1xk 107 14 . . . cord-297469-26d8o1xk 108 1 These these DT cord-297469-26d8o1xk 108 2 changes change NNS cord-297469-26d8o1xk 108 3 demonstrate demonstrate VBP cord-297469-26d8o1xk 108 4 that that IN cord-297469-26d8o1xk 108 5 UA UA NNP cord-297469-26d8o1xk 108 6 promotes promote VBZ cord-297469-26d8o1xk 108 7 the the DT cord-297469-26d8o1xk 108 8 production production NN cord-297469-26d8o1xk 108 9 and and CC cord-297469-26d8o1xk 108 10 the the DT cord-297469-26d8o1xk 108 11 expression expression NN cord-297469-26d8o1xk 108 12 of of IN cord-297469-26d8o1xk 108 13 IL-10 IL-10 NNP cord-297469-26d8o1xk 108 14 and and CC cord-297469-26d8o1xk 108 15 IL-12 IL-12 NNP cord-297469-26d8o1xk 108 16 by by IN cord-297469-26d8o1xk 108 17 consistently consistently RB cord-297469-26d8o1xk 108 18 stimulating stimulate VBG cord-297469-26d8o1xk 108 19 the the DT cord-297469-26d8o1xk 108 20 immune immune JJ cord-297469-26d8o1xk 108 21 cells cell NNS cord-297469-26d8o1xk 108 22 as as RB cord-297469-26d8o1xk 108 23 well well RB cord-297469-26d8o1xk 108 24 as as IN cord-297469-26d8o1xk 108 25 inhibit inhibit VB cord-297469-26d8o1xk 108 26 the the DT cord-297469-26d8o1xk 108 27 expressions expression NNS cord-297469-26d8o1xk 108 28 of of IN cord-297469-26d8o1xk 108 29 IL-1β IL-1β NNP cord-297469-26d8o1xk 108 30 and and CC cord-297469-26d8o1xk 108 31 IL-6 IL-6 NNP cord-297469-26d8o1xk 108 32 induced induce VBN cord-297469-26d8o1xk 108 33 by by IN cord-297469-26d8o1xk 108 34 T. T. NNP cord-297469-26d8o1xk 108 35 gondii gondii NNP cord-297469-26d8o1xk 108 36 infection infection NN cord-297469-26d8o1xk 108 37 . . . cord-297469-26d8o1xk 109 1 Interestingly interestingly RB cord-297469-26d8o1xk 109 2 , , , cord-297469-26d8o1xk 109 3 the the DT cord-297469-26d8o1xk 109 4 production production NN cord-297469-26d8o1xk 109 5 of of IN cord-297469-26d8o1xk 109 6 IL-1β il-1β NN cord-297469-26d8o1xk 109 7 in in IN cord-297469-26d8o1xk 109 8 T. T. NNP cord-297469-26d8o1xk 109 9 gondii gondii NN cord-297469-26d8o1xk 109 10 - - HYPH cord-297469-26d8o1xk 109 11 infected infect VBN cord-297469-26d8o1xk 109 12 cells cell NNS cord-297469-26d8o1xk 109 13 treated treat VBN cord-297469-26d8o1xk 109 14 with with IN cord-297469-26d8o1xk 109 15 SF SF NNP cord-297469-26d8o1xk 109 16 was be VBD cord-297469-26d8o1xk 109 17 significantly significantly RB cord-297469-26d8o1xk 109 18 increased increase VBN cord-297469-26d8o1xk 109 19 and and CC cord-297469-26d8o1xk 109 20 the the DT cord-297469-26d8o1xk 109 21 expression expression NN cord-297469-26d8o1xk 109 22 of of IN cord-297469-26d8o1xk 109 23 IL-10 IL-10 NNP cord-297469-26d8o1xk 109 24 was be VBD cord-297469-26d8o1xk 109 25 gradually gradually RB cord-297469-26d8o1xk 109 26 decreased decrease VBN cord-297469-26d8o1xk 109 27 compared compare VBN cord-297469-26d8o1xk 109 28 with with IN cord-297469-26d8o1xk 109 29 the the DT cord-297469-26d8o1xk 109 30 infection infection NN cord-297469-26d8o1xk 109 31 group group NN cord-297469-26d8o1xk 109 32 . . . cord-297469-26d8o1xk 110 1 However however RB cord-297469-26d8o1xk 110 2 , , , cord-297469-26d8o1xk 110 3 there there EX cord-297469-26d8o1xk 110 4 were be VBD cord-297469-26d8o1xk 110 5 no no DT cord-297469-26d8o1xk 110 6 significant significant JJ cord-297469-26d8o1xk 110 7 changes change NNS cord-297469-26d8o1xk 110 8 of of IN cord-297469-26d8o1xk 110 9 the the DT cord-297469-26d8o1xk 110 10 production production NN cord-297469-26d8o1xk 110 11 of of IN cord-297469-26d8o1xk 110 12 IL-6 IL-6 NNP cord-297469-26d8o1xk 110 13 and and CC cord-297469-26d8o1xk 110 14 IL-12 IL-12 NNP cord-297469-26d8o1xk 110 15 in in IN cord-297469-26d8o1xk 110 16 T. T. NNP cord-297469-26d8o1xk 110 17 gondii gondii NN cord-297469-26d8o1xk 110 18 - - HYPH cord-297469-26d8o1xk 110 19 infected infect VBN cord-297469-26d8o1xk 110 20 cells cell NNS cord-297469-26d8o1xk 110 21 treated treat VBN cord-297469-26d8o1xk 110 22 with with IN cord-297469-26d8o1xk 110 23 SF SF NNP cord-297469-26d8o1xk 110 24 . . . cord-297469-26d8o1xk 111 1 In in IN cord-297469-26d8o1xk 111 2 particular particular JJ cord-297469-26d8o1xk 111 3 , , , cord-297469-26d8o1xk 111 4 significant significant JJ cord-297469-26d8o1xk 111 5 differences difference NNS cord-297469-26d8o1xk 111 6 in in IN cord-297469-26d8o1xk 111 7 the the DT cord-297469-26d8o1xk 111 8 cytokines cytokine NNS cord-297469-26d8o1xk 111 9 were be VBD cord-297469-26d8o1xk 111 10 clearly clearly RB cord-297469-26d8o1xk 111 11 measured measure VBN cord-297469-26d8o1xk 111 12 between between IN cord-297469-26d8o1xk 111 13 the the DT cord-297469-26d8o1xk 111 14 T. T. NNP cord-297469-26d8o1xk 111 15 gondiiinfected gondiiinfected NNP cord-297469-26d8o1xk 111 16 group group NN cord-297469-26d8o1xk 111 17 and and CC cord-297469-26d8o1xk 111 18 UA UA NNP cord-297469-26d8o1xk 111 19 - - HYPH cord-297469-26d8o1xk 111 20 treated treat VBN cord-297469-26d8o1xk 111 21 group group NN cord-297469-26d8o1xk 111 22 , , , cord-297469-26d8o1xk 111 23 and and CC cord-297469-26d8o1xk 111 24 these these DT cord-297469-26d8o1xk 111 25 changes change NNS cord-297469-26d8o1xk 111 26 of of IN cord-297469-26d8o1xk 111 27 cytokines cytokine NNS cord-297469-26d8o1xk 111 28 were be VBD cord-297469-26d8o1xk 111 29 confirmed confirm VBN cord-297469-26d8o1xk 111 30 in in IN cord-297469-26d8o1xk 111 31 all all PDT cord-297469-26d8o1xk 111 32 the the DT cord-297469-26d8o1xk 111 33 groups group NNS cord-297469-26d8o1xk 111 34 . . . cord-297469-26d8o1xk 112 1 Furthermore furthermore RB cord-297469-26d8o1xk 112 2 , , , cord-297469-26d8o1xk 112 3 the the DT cord-297469-26d8o1xk 112 4 results result NNS cord-297469-26d8o1xk 112 5 show show VBP cord-297469-26d8o1xk 112 6 that that IN cord-297469-26d8o1xk 112 7 this this DT cord-297469-26d8o1xk 112 8 co co NN cord-297469-26d8o1xk 112 9 - - NN cord-297469-26d8o1xk 112 10 culture culture JJ cord-297469-26d8o1xk 112 11 system system NN cord-297469-26d8o1xk 112 12 through through IN cord-297469-26d8o1xk 112 13 immune immune JJ cord-297469-26d8o1xk 112 14 cells cell NNS cord-297469-26d8o1xk 112 15 can can MD cord-297469-26d8o1xk 112 16 be be VB cord-297469-26d8o1xk 112 17 usefully usefully RB cord-297469-26d8o1xk 112 18 utilized utilize VBN cord-297469-26d8o1xk 112 19 as as IN cord-297469-26d8o1xk 112 20 a a DT cord-297469-26d8o1xk 112 21 co co NN cord-297469-26d8o1xk 112 22 - - NN cord-297469-26d8o1xk 112 23 culture culture JJ cord-297469-26d8o1xk 112 24 method method NN cord-297469-26d8o1xk 112 25 for for IN cord-297469-26d8o1xk 112 26 measuring measure VBG cord-297469-26d8o1xk 112 27 various various JJ cord-297469-26d8o1xk 112 28 cytokines cytokine NNS cord-297469-26d8o1xk 112 29 , , , cord-297469-26d8o1xk 112 30 and and CC cord-297469-26d8o1xk 112 31 as as IN cord-297469-26d8o1xk 112 32 an an DT cord-297469-26d8o1xk 112 33 effective effective JJ cord-297469-26d8o1xk 112 34 alternative alternative NN cord-297469-26d8o1xk 112 35 to to IN cord-297469-26d8o1xk 112 36 in in IN cord-297469-26d8o1xk 112 37 vivo vivo NN cord-297469-26d8o1xk 112 38 experiments experiment NNS cord-297469-26d8o1xk 112 39 . . . cord-297469-26d8o1xk 113 1 These these DT cord-297469-26d8o1xk 113 2 results result NNS cord-297469-26d8o1xk 113 3 indicate indicate VBP cord-297469-26d8o1xk 113 4 that that IN cord-297469-26d8o1xk 113 5 UA UA NNP cord-297469-26d8o1xk 113 6 not not RB cord-297469-26d8o1xk 113 7 only only RB cord-297469-26d8o1xk 113 8 effectively effectively RB cord-297469-26d8o1xk 113 9 induces induce VBZ cord-297469-26d8o1xk 113 10 the the DT cord-297469-26d8o1xk 113 11 production production NN cord-297469-26d8o1xk 113 12 of of IN cord-297469-26d8o1xk 113 13 cytokines cytokine NNS cord-297469-26d8o1xk 113 14 between between IN cord-297469-26d8o1xk 113 15 the the DT cord-297469-26d8o1xk 113 16 immune immune JJ cord-297469-26d8o1xk 113 17 cells cell NNS cord-297469-26d8o1xk 113 18 by by IN cord-297469-26d8o1xk 113 19 increasing increase VBG cord-297469-26d8o1xk 113 20 the the DT cord-297469-26d8o1xk 113 21 expression expression NN cord-297469-26d8o1xk 113 22 of of IN cord-297469-26d8o1xk 113 23 IL-10 IL-10 NNP cord-297469-26d8o1xk 113 24 and and CC cord-297469-26d8o1xk 113 25 IL-12 IL-12 NNP cord-297469-26d8o1xk 113 26 in in IN cord-297469-26d8o1xk 113 27 macrophage macrophage NN cord-297469-26d8o1xk 113 28 and and CC cord-297469-26d8o1xk 113 29 B b NN cord-297469-26d8o1xk 113 30 cells cell NNS cord-297469-26d8o1xk 113 31 after after IN cord-297469-26d8o1xk 113 32 T. t. NN cord-297469-26d8o1xk 113 33 gondii gondii NN cord-297469-26d8o1xk 113 34 infection infection NN cord-297469-26d8o1xk 113 35 , , , cord-297469-26d8o1xk 113 36 but but CC cord-297469-26d8o1xk 113 37 also also RB cord-297469-26d8o1xk 113 38 suppresses suppress VBZ cord-297469-26d8o1xk 113 39 or or CC cord-297469-26d8o1xk 113 40 strongly strongly RB cord-297469-26d8o1xk 113 41 reduces reduce VBZ cord-297469-26d8o1xk 113 42 the the DT cord-297469-26d8o1xk 113 43 expression expression NN cord-297469-26d8o1xk 113 44 of of IN cord-297469-26d8o1xk 113 45 the the DT cord-297469-26d8o1xk 113 46 inflammatory inflammatory JJ cord-297469-26d8o1xk 113 47 cytokines cytokine NNS cord-297469-26d8o1xk 113 48 from from IN cord-297469-26d8o1xk 113 49 the the DT cord-297469-26d8o1xk 113 50 immune immune JJ cord-297469-26d8o1xk 113 51 cells cell NNS cord-297469-26d8o1xk 113 52 . . . cord-297469-26d8o1xk 113 53 _SP cord-297469-26d8o1xk 114 1 In in IN cord-297469-26d8o1xk 114 2 spite spite NN cord-297469-26d8o1xk 114 3 of of IN cord-297469-26d8o1xk 114 4 constant constant JJ cord-297469-26d8o1xk 114 5 public public JJ cord-297469-26d8o1xk 114 6 health health NN cord-297469-26d8o1xk 114 7 efforts effort NNS cord-297469-26d8o1xk 114 8 worldwide worldwide RB cord-297469-26d8o1xk 114 9 for for IN cord-297469-26d8o1xk 114 10 the the DT cord-297469-26d8o1xk 114 11 past past JJ cord-297469-26d8o1xk 114 12 decades decade NNS cord-297469-26d8o1xk 114 13 , , , cord-297469-26d8o1xk 114 14 infectious infectious JJ cord-297469-26d8o1xk 114 15 diseases disease NNS cord-297469-26d8o1xk 114 16 such such JJ cord-297469-26d8o1xk 114 17 as as IN cord-297469-26d8o1xk 114 18 malaria malaria NN cord-297469-26d8o1xk 114 19 , , , cord-297469-26d8o1xk 114 20 influenza influenza NN cord-297469-26d8o1xk 114 21 , , , cord-297469-26d8o1xk 114 22 cholera cholera NN cord-297469-26d8o1xk 114 23 , , , cord-297469-26d8o1xk 114 24 yellow yellow JJ cord-297469-26d8o1xk 114 25 fever fever NN cord-297469-26d8o1xk 114 26 , , , cord-297469-26d8o1xk 114 27 MERS MERS NNP cord-297469-26d8o1xk 114 28 , , , cord-297469-26d8o1xk 114 29 SARS SARS NNP cord-297469-26d8o1xk 114 30 , , , cord-297469-26d8o1xk 114 31 and and CC cord-297469-26d8o1xk 114 32 tuberculosis tuberculosis NN cord-297469-26d8o1xk 114 33 have have VBP cord-297469-26d8o1xk 114 34 been be VBN cord-297469-26d8o1xk 114 35 consistently consistently RB cord-297469-26d8o1xk 114 36 causing cause VBG cord-297469-26d8o1xk 114 37 crises crisis NNS cord-297469-26d8o1xk 114 38 in in IN cord-297469-26d8o1xk 114 39 public public JJ cord-297469-26d8o1xk 114 40 health health NN cord-297469-26d8o1xk 114 41 as as RB cord-297469-26d8o1xk 114 42 well well RB cord-297469-26d8o1xk 114 43 as as IN cord-297469-26d8o1xk 114 44 global global JJ cord-297469-26d8o1xk 114 45 concerns concern NNS cord-297469-26d8o1xk 114 46 due due IN cord-297469-26d8o1xk 114 47 to to IN cord-297469-26d8o1xk 114 48 their -PRON- PRP$ cord-297469-26d8o1xk 114 49 pandemic pandemic NN cord-297469-26d8o1xk 114 50 potential potential NN cord-297469-26d8o1xk 114 51 . . . cord-297469-26d8o1xk 115 1 These these DT cord-297469-26d8o1xk 115 2 serious serious JJ cord-297469-26d8o1xk 115 3 infectious infectious JJ cord-297469-26d8o1xk 115 4 pathogens pathogen NNS cord-297469-26d8o1xk 115 5 have have VBP cord-297469-26d8o1xk 115 6 enhanced enhance VBN cord-297469-26d8o1xk 115 7 adaptability adaptability NN cord-297469-26d8o1xk 115 8 to to IN cord-297469-26d8o1xk 115 9 environmental environmental JJ cord-297469-26d8o1xk 115 10 variation variation NN cord-297469-26d8o1xk 115 11 and and CC cord-297469-26d8o1xk 115 12 infectivity infectivity NN cord-297469-26d8o1xk 115 13 to to TO cord-297469-26d8o1xk 115 14 host host VB cord-297469-26d8o1xk 115 15 as as RB cord-297469-26d8o1xk 115 16 well well RB cord-297469-26d8o1xk 115 17 as as IN cord-297469-26d8o1xk 115 18 resistance resistance NN cord-297469-26d8o1xk 115 19 to to IN cord-297469-26d8o1xk 115 20 existing exist VBG cord-297469-26d8o1xk 115 21 drugs drug NNS cord-297469-26d8o1xk 115 22 for for IN cord-297469-26d8o1xk 115 23 their -PRON- PRP$ cord-297469-26d8o1xk 115 24 viability viability NN cord-297469-26d8o1xk 115 25 , , , cord-297469-26d8o1xk 115 26 evolving evolve VBG cord-297469-26d8o1xk 115 27 in in IN cord-297469-26d8o1xk 115 28 a a DT cord-297469-26d8o1xk 115 29 time time NN cord-297469-26d8o1xk 115 30 - - HYPH cord-297469-26d8o1xk 115 31 dependent dependent JJ cord-297469-26d8o1xk 115 32 manner manner NN cord-297469-26d8o1xk 115 33 . . . cord-297469-26d8o1xk 116 1 In in IN cord-297469-26d8o1xk 116 2 these these DT cord-297469-26d8o1xk 116 3 aspects aspect NNS cord-297469-26d8o1xk 116 4 , , , cord-297469-26d8o1xk 116 5 global global JJ cord-297469-26d8o1xk 116 6 nonprofit nonprofit JJ cord-297469-26d8o1xk 116 7 organizations organization NNS cord-297469-26d8o1xk 116 8 and/or and/or CC cord-297469-26d8o1xk 116 9 profit profit NN cord-297469-26d8o1xk 116 10 companies company NNS cord-297469-26d8o1xk 116 11 such such JJ cord-297469-26d8o1xk 116 12 as as IN cord-297469-26d8o1xk 116 13 WHO WHO NNP cord-297469-26d8o1xk 116 14 and and CC cord-297469-26d8o1xk 116 15 the the DT cord-297469-26d8o1xk 116 16 Bill Bill NNP cord-297469-26d8o1xk 116 17 & & CC cord-297469-26d8o1xk 116 18 Melinda Melinda NNP cord-297469-26d8o1xk 116 19 Gates Gates NNP cord-297469-26d8o1xk 116 20 Foundation Foundation NNP cord-297469-26d8o1xk 116 21 as as RB cord-297469-26d8o1xk 116 22 well well RB cord-297469-26d8o1xk 116 23 as as IN cord-297469-26d8o1xk 116 24 various various JJ cord-297469-26d8o1xk 116 25 global global JJ cord-297469-26d8o1xk 116 26 leading leading JJ cord-297469-26d8o1xk 116 27 pharmaceutical pharmaceutical JJ cord-297469-26d8o1xk 116 28 companies company NNS cord-297469-26d8o1xk 116 29 have have VBP cord-297469-26d8o1xk 116 30 continuously continuously RB cord-297469-26d8o1xk 116 31 supported support VBN cord-297469-26d8o1xk 116 32 the the DT cord-297469-26d8o1xk 116 33 study study NN cord-297469-26d8o1xk 116 34 for for IN cord-297469-26d8o1xk 116 35 blocking block VBG cord-297469-26d8o1xk 116 36 or or CC cord-297469-26d8o1xk 116 37 treating treat VBG cord-297469-26d8o1xk 116 38 chronic chronic JJ cord-297469-26d8o1xk 116 39 infectious infectious JJ cord-297469-26d8o1xk 116 40 diseases disease NNS cord-297469-26d8o1xk 116 41 such such JJ cord-297469-26d8o1xk 116 42 as as IN cord-297469-26d8o1xk 116 43 Zika Zika NNP cord-297469-26d8o1xk 116 44 , , , cord-297469-26d8o1xk 116 45 AIDS AIDS NNP cord-297469-26d8o1xk 116 46 , , , cord-297469-26d8o1xk 116 47 and and CC cord-297469-26d8o1xk 116 48 tuberculosis tuberculosis NN cord-297469-26d8o1xk 116 49 as as RB cord-297469-26d8o1xk 116 50 well well RB cord-297469-26d8o1xk 116 51 as as IN cord-297469-26d8o1xk 116 52 acute acute JJ cord-297469-26d8o1xk 116 53 infectious infectious JJ cord-297469-26d8o1xk 116 54 diseases disease NNS cord-297469-26d8o1xk 116 55 including include VBG cord-297469-26d8o1xk 116 56 influenza influenza NN cord-297469-26d8o1xk 116 57 , , , cord-297469-26d8o1xk 116 58 malaria malaria NN cord-297469-26d8o1xk 116 59 , , , cord-297469-26d8o1xk 116 60 cholera cholera NN cord-297469-26d8o1xk 116 61 , , , cord-297469-26d8o1xk 116 62 yellow yellow JJ cord-297469-26d8o1xk 116 63 fever fever NN cord-297469-26d8o1xk 116 64 , , , cord-297469-26d8o1xk 116 65 and and CC cord-297469-26d8o1xk 116 66 Ebola Ebola NNP cord-297469-26d8o1xk 116 67 , , , cord-297469-26d8o1xk 116 68 focusing focus VBG cord-297469-26d8o1xk 116 69 on on IN cord-297469-26d8o1xk 116 70 the the DT cord-297469-26d8o1xk 116 71 development development NN cord-297469-26d8o1xk 116 72 of of IN cord-297469-26d8o1xk 116 73 novel novel JJ cord-297469-26d8o1xk 116 74 drugs drug NNS cord-297469-26d8o1xk 116 75 and and CC cord-297469-26d8o1xk 116 76 effective effective JJ cord-297469-26d8o1xk 116 77 vaccine vaccine NN cord-297469-26d8o1xk 116 78 against against IN cord-297469-26d8o1xk 116 79 pathogens pathogen NNS cord-297469-26d8o1xk 116 80 . . . cord-297469-26d8o1xk 117 1 Furthermore furthermore RB cord-297469-26d8o1xk 117 2 , , , cord-297469-26d8o1xk 117 3 in in IN cord-297469-26d8o1xk 117 4 spite spite NN cord-297469-26d8o1xk 117 5 of of IN cord-297469-26d8o1xk 117 6 various various JJ cord-297469-26d8o1xk 117 7 efforts effort NNS cord-297469-26d8o1xk 117 8 for for IN cord-297469-26d8o1xk 117 9 developing develop VBG cord-297469-26d8o1xk 117 10 anti anti JJ cord-297469-26d8o1xk 117 11 - - JJ cord-297469-26d8o1xk 117 12 parasitic parasitic JJ cord-297469-26d8o1xk 117 13 drugs drug NNS cord-297469-26d8o1xk 117 14 against against IN cord-297469-26d8o1xk 117 15 zoonotic zoonotic JJ cord-297469-26d8o1xk 117 16 parasitosis parasitosis NN cord-297469-26d8o1xk 117 17 , , , cord-297469-26d8o1xk 117 18 effective effective JJ cord-297469-26d8o1xk 117 19 novel novel JJ cord-297469-26d8o1xk 117 20 drugs drug NNS cord-297469-26d8o1xk 117 21 such such JJ cord-297469-26d8o1xk 117 22 as as IN cord-297469-26d8o1xk 117 23 anti anti JJ cord-297469-26d8o1xk 117 24 - - JJ cord-297469-26d8o1xk 117 25 malaria malaria JJ cord-297469-26d8o1xk 117 26 drugs drug NNS cord-297469-26d8o1xk 117 27 have have VBP cord-297469-26d8o1xk 117 28 not not RB cord-297469-26d8o1xk 117 29 yet yet RB cord-297469-26d8o1xk 117 30 been be VBN cord-297469-26d8o1xk 117 31 developed develop VBN cord-297469-26d8o1xk 117 32 or or CC cord-297469-26d8o1xk 117 33 launched launch VBN cord-297469-26d8o1xk 117 34 . . . cord-297469-26d8o1xk 118 1 Many many JJ cord-297469-26d8o1xk 118 2 people people NNS cord-297469-26d8o1xk 118 3 are be VBP cord-297469-26d8o1xk 118 4 living live VBG cord-297469-26d8o1xk 118 5 with with IN cord-297469-26d8o1xk 118 6 animals animal NNS cord-297469-26d8o1xk 118 7 such such JJ cord-297469-26d8o1xk 118 8 as as IN cord-297469-26d8o1xk 118 9 cats cat NNS cord-297469-26d8o1xk 118 10 and and CC cord-297469-26d8o1xk 118 11 dogs dog NNS cord-297469-26d8o1xk 118 12 . . . cord-297469-26d8o1xk 119 1 In in IN cord-297469-26d8o1xk 119 2 particular particular JJ cord-297469-26d8o1xk 119 3 , , , cord-297469-26d8o1xk 119 4 toxoplasmosis toxoplasmosis NN cord-297469-26d8o1xk 119 5 , , , cord-297469-26d8o1xk 119 6 a a DT cord-297469-26d8o1xk 119 7 zoonotic zoonotic JJ cord-297469-26d8o1xk 119 8 parasitosis parasitosis NN cord-297469-26d8o1xk 119 9 , , , cord-297469-26d8o1xk 119 10 is be VBZ cord-297469-26d8o1xk 119 11 transmitted transmit VBN cord-297469-26d8o1xk 119 12 via via IN cord-297469-26d8o1xk 119 13 physical physical JJ cord-297469-26d8o1xk 119 14 contact contact NN cord-297469-26d8o1xk 119 15 with with IN cord-297469-26d8o1xk 119 16 pets pet NNS cord-297469-26d8o1xk 119 17 and and CC cord-297469-26d8o1xk 119 18 companion companion NN cord-297469-26d8o1xk 119 19 animals animal NNS cord-297469-26d8o1xk 119 20 , , , cord-297469-26d8o1xk 119 21 including include VBG cord-297469-26d8o1xk 119 22 cat cat NN cord-297469-26d8o1xk 119 23 and and CC cord-297469-26d8o1xk 119 24 dogs dog NNS cord-297469-26d8o1xk 119 25 . . . cord-297469-26d8o1xk 120 1 With with IN cord-297469-26d8o1xk 120 2 respect respect NN cord-297469-26d8o1xk 120 3 to to IN cord-297469-26d8o1xk 120 4 these these DT cord-297469-26d8o1xk 120 5 aspects aspect NNS cord-297469-26d8o1xk 120 6 , , , cord-297469-26d8o1xk 120 7 we -PRON- PRP cord-297469-26d8o1xk 120 8 carefully carefully RB cord-297469-26d8o1xk 120 9 focused focus VBD cord-297469-26d8o1xk 120 10 on on IN cord-297469-26d8o1xk 120 11 the the DT cord-297469-26d8o1xk 120 12 parasitic parasitic JJ cord-297469-26d8o1xk 120 13 infectious infectious JJ cord-297469-26d8o1xk 120 14 diseases disease NNS cord-297469-26d8o1xk 120 15 that that WDT cord-297469-26d8o1xk 120 16 are be VBP cord-297469-26d8o1xk 120 17 consistently consistently RB cord-297469-26d8o1xk 120 18 caused cause VBN cord-297469-26d8o1xk 120 19 through through IN cord-297469-26d8o1xk 120 20 various various JJ cord-297469-26d8o1xk 120 21 infection infection NN cord-297469-26d8o1xk 120 22 pathways pathway NNS cord-297469-26d8o1xk 120 23 and and CC cord-297469-26d8o1xk 120 24 factors factor NNS cord-297469-26d8o1xk 120 25 . . . cord-297469-26d8o1xk 121 1 Among among IN cord-297469-26d8o1xk 121 2 various various JJ cord-297469-26d8o1xk 121 3 parasites parasite NNS cord-297469-26d8o1xk 121 4 , , , cord-297469-26d8o1xk 121 5 T. T. NNP cord-297469-26d8o1xk 121 6 gondii gondii NNP cord-297469-26d8o1xk 121 7 induces induce VBZ cord-297469-26d8o1xk 121 8 serious serious JJ cord-297469-26d8o1xk 121 9 symptoms symptom NNS cord-297469-26d8o1xk 121 10 such such JJ cord-297469-26d8o1xk 121 11 as as IN cord-297469-26d8o1xk 121 12 cerebral cerebral JJ cord-297469-26d8o1xk 121 13 calcification calcification NN cord-297469-26d8o1xk 121 14 and and CC cord-297469-26d8o1xk 121 15 meningoencephalitis meningoencephalitis NN cord-297469-26d8o1xk 121 16 in in IN cord-297469-26d8o1xk 121 17 the the DT cord-297469-26d8o1xk 121 18 brain brain NN cord-297469-26d8o1xk 121 19 , , , cord-297469-26d8o1xk 121 20 while while IN cord-297469-26d8o1xk 121 21 causing cause VBG cord-297469-26d8o1xk 121 22 fetal fetal JJ cord-297469-26d8o1xk 121 23 infection infection NN cord-297469-26d8o1xk 121 24 through through IN cord-297469-26d8o1xk 121 25 mother mother NN cord-297469-26d8o1xk 121 26 during during IN cord-297469-26d8o1xk 121 27 pregnancy pregnancy NN cord-297469-26d8o1xk 121 28 , , , cord-297469-26d8o1xk 121 29 as as IN cord-297469-26d8o1xk 121 30 it -PRON- PRP cord-297469-26d8o1xk 121 31 is be VBZ cord-297469-26d8o1xk 121 32 a a DT cord-297469-26d8o1xk 121 33 zoonotic zoonotic JJ cord-297469-26d8o1xk 121 34 parasite parasite NN cord-297469-26d8o1xk 121 35 which which WDT cord-297469-26d8o1xk 121 36 affects affect VBZ cord-297469-26d8o1xk 121 37 both both DT cord-297469-26d8o1xk 121 38 humans human NNS cord-297469-26d8o1xk 121 39 and and CC cord-297469-26d8o1xk 121 40 animals animal NNS cord-297469-26d8o1xk 121 41 , , , cord-297469-26d8o1xk 121 42 resulting result VBG cord-297469-26d8o1xk 121 43 in in IN cord-297469-26d8o1xk 121 44 parasitic parasitic JJ cord-297469-26d8o1xk 121 45 diseases disease NNS cord-297469-26d8o1xk 121 46 such such JJ cord-297469-26d8o1xk 121 47 as as IN cord-297469-26d8o1xk 121 48 toxoplasmosis toxoplasmosi NNS cord-297469-26d8o1xk 121 49 [ [ -LRB- cord-297469-26d8o1xk 121 50 49 49 CD cord-297469-26d8o1xk 121 51 , , , cord-297469-26d8o1xk 121 52 50 50 CD cord-297469-26d8o1xk 121 53 ] ] -RRB- cord-297469-26d8o1xk 121 54 . . . cord-297469-26d8o1xk 121 55 _SP cord-297469-26d8o1xk 122 1 In in IN cord-297469-26d8o1xk 122 2 spite spite NN cord-297469-26d8o1xk 122 3 of of IN cord-297469-26d8o1xk 122 4 constant constant JJ cord-297469-26d8o1xk 122 5 public public JJ cord-297469-26d8o1xk 122 6 health health NN cord-297469-26d8o1xk 122 7 efforts effort NNS cord-297469-26d8o1xk 122 8 worldwide worldwide RB cord-297469-26d8o1xk 122 9 for for IN cord-297469-26d8o1xk 122 10 the the DT cord-297469-26d8o1xk 122 11 past past JJ cord-297469-26d8o1xk 122 12 decades decade NNS cord-297469-26d8o1xk 122 13 , , , cord-297469-26d8o1xk 122 14 infectious infectious JJ cord-297469-26d8o1xk 122 15 diseases disease NNS cord-297469-26d8o1xk 122 16 such such JJ cord-297469-26d8o1xk 122 17 as as IN cord-297469-26d8o1xk 122 18 malaria malaria NN cord-297469-26d8o1xk 122 19 , , , cord-297469-26d8o1xk 122 20 influenza influenza NN cord-297469-26d8o1xk 122 21 , , , cord-297469-26d8o1xk 122 22 cholera cholera NN cord-297469-26d8o1xk 122 23 , , , cord-297469-26d8o1xk 122 24 yellow yellow JJ cord-297469-26d8o1xk 122 25 fever fever NN cord-297469-26d8o1xk 122 26 , , , cord-297469-26d8o1xk 122 27 MERS MERS NNP cord-297469-26d8o1xk 122 28 , , , cord-297469-26d8o1xk 122 29 SARS SARS NNP cord-297469-26d8o1xk 122 30 , , , cord-297469-26d8o1xk 122 31 and and CC cord-297469-26d8o1xk 122 32 tuberculosis tuberculosis NN cord-297469-26d8o1xk 122 33 have have VBP cord-297469-26d8o1xk 122 34 been be VBN cord-297469-26d8o1xk 122 35 consistently consistently RB cord-297469-26d8o1xk 122 36 causing cause VBG cord-297469-26d8o1xk 122 37 crises crisis NNS cord-297469-26d8o1xk 122 38 in in IN cord-297469-26d8o1xk 122 39 public public JJ cord-297469-26d8o1xk 122 40 health health NN cord-297469-26d8o1xk 122 41 as as RB cord-297469-26d8o1xk 122 42 well well RB cord-297469-26d8o1xk 122 43 as as IN cord-297469-26d8o1xk 122 44 global global JJ cord-297469-26d8o1xk 122 45 concerns concern NNS cord-297469-26d8o1xk 122 46 due due IN cord-297469-26d8o1xk 122 47 to to IN cord-297469-26d8o1xk 122 48 their -PRON- PRP$ cord-297469-26d8o1xk 122 49 pandemic pandemic NN cord-297469-26d8o1xk 122 50 potential potential NN cord-297469-26d8o1xk 122 51 . . . cord-297469-26d8o1xk 123 1 These these DT cord-297469-26d8o1xk 123 2 serious serious JJ cord-297469-26d8o1xk 123 3 infectious infectious JJ cord-297469-26d8o1xk 123 4 pathogens pathogen NNS cord-297469-26d8o1xk 123 5 have have VBP cord-297469-26d8o1xk 123 6 enhanced enhance VBN cord-297469-26d8o1xk 123 7 adaptability adaptability NN cord-297469-26d8o1xk 123 8 to to IN cord-297469-26d8o1xk 123 9 environmental environmental JJ cord-297469-26d8o1xk 123 10 variation variation NN cord-297469-26d8o1xk 123 11 and and CC cord-297469-26d8o1xk 123 12 infectivity infectivity NN cord-297469-26d8o1xk 123 13 to to TO cord-297469-26d8o1xk 123 14 host host VB cord-297469-26d8o1xk 123 15 as as RB cord-297469-26d8o1xk 123 16 well well RB cord-297469-26d8o1xk 123 17 as as IN cord-297469-26d8o1xk 123 18 resistance resistance NN cord-297469-26d8o1xk 123 19 to to IN cord-297469-26d8o1xk 123 20 existing exist VBG cord-297469-26d8o1xk 123 21 drugs drug NNS cord-297469-26d8o1xk 123 22 for for IN cord-297469-26d8o1xk 123 23 their -PRON- PRP$ cord-297469-26d8o1xk 123 24 viability viability NN cord-297469-26d8o1xk 123 25 , , , cord-297469-26d8o1xk 123 26 evolving evolve VBG cord-297469-26d8o1xk 123 27 in in IN cord-297469-26d8o1xk 123 28 a a DT cord-297469-26d8o1xk 123 29 time time NN cord-297469-26d8o1xk 123 30 - - HYPH cord-297469-26d8o1xk 123 31 dependent dependent JJ cord-297469-26d8o1xk 123 32 manner manner NN cord-297469-26d8o1xk 123 33 . . . cord-297469-26d8o1xk 124 1 In in IN cord-297469-26d8o1xk 124 2 these these DT cord-297469-26d8o1xk 124 3 aspects aspect NNS cord-297469-26d8o1xk 124 4 , , , cord-297469-26d8o1xk 124 5 global global JJ cord-297469-26d8o1xk 124 6 nonprofit nonprofit JJ cord-297469-26d8o1xk 124 7 organizations organization NNS cord-297469-26d8o1xk 124 8 and/or and/or CC cord-297469-26d8o1xk 124 9 profit profit NN cord-297469-26d8o1xk 124 10 companies company NNS cord-297469-26d8o1xk 124 11 such such JJ cord-297469-26d8o1xk 124 12 as as IN cord-297469-26d8o1xk 124 13 WHO WHO NNP cord-297469-26d8o1xk 124 14 and and CC cord-297469-26d8o1xk 124 15 the the DT cord-297469-26d8o1xk 124 16 Bill Bill NNP cord-297469-26d8o1xk 124 17 & & CC cord-297469-26d8o1xk 124 18 Melinda Melinda NNP cord-297469-26d8o1xk 124 19 Gates Gates NNP cord-297469-26d8o1xk 124 20 Foundation Foundation NNP cord-297469-26d8o1xk 124 21 as as RB cord-297469-26d8o1xk 124 22 well well RB cord-297469-26d8o1xk 124 23 as as IN cord-297469-26d8o1xk 124 24 various various JJ cord-297469-26d8o1xk 124 25 global global JJ cord-297469-26d8o1xk 124 26 leading leading JJ cord-297469-26d8o1xk 124 27 pharmaceutical pharmaceutical JJ cord-297469-26d8o1xk 124 28 companies company NNS cord-297469-26d8o1xk 124 29 have have VBP cord-297469-26d8o1xk 124 30 continuously continuously RB cord-297469-26d8o1xk 124 31 supported support VBN cord-297469-26d8o1xk 124 32 the the DT cord-297469-26d8o1xk 124 33 study study NN cord-297469-26d8o1xk 124 34 for for IN cord-297469-26d8o1xk 124 35 blocking block VBG cord-297469-26d8o1xk 124 36 or or CC cord-297469-26d8o1xk 124 37 treating treat VBG cord-297469-26d8o1xk 124 38 chronic chronic JJ cord-297469-26d8o1xk 124 39 infectious infectious JJ cord-297469-26d8o1xk 124 40 diseases disease NNS cord-297469-26d8o1xk 124 41 such such JJ cord-297469-26d8o1xk 124 42 as as IN cord-297469-26d8o1xk 124 43 Zika Zika NNP cord-297469-26d8o1xk 124 44 , , , cord-297469-26d8o1xk 124 45 AIDS AIDS NNP cord-297469-26d8o1xk 124 46 , , , cord-297469-26d8o1xk 124 47 and and CC cord-297469-26d8o1xk 124 48 tuberculosis tuberculosis NN cord-297469-26d8o1xk 124 49 as as RB cord-297469-26d8o1xk 124 50 well well RB cord-297469-26d8o1xk 124 51 as as IN cord-297469-26d8o1xk 124 52 acute acute JJ cord-297469-26d8o1xk 124 53 infectious infectious JJ cord-297469-26d8o1xk 124 54 diseases disease NNS cord-297469-26d8o1xk 124 55 including include VBG cord-297469-26d8o1xk 124 56 influenza influenza NN cord-297469-26d8o1xk 124 57 , , , cord-297469-26d8o1xk 124 58 malaria malaria NN cord-297469-26d8o1xk 124 59 , , , cord-297469-26d8o1xk 124 60 cholera cholera NN cord-297469-26d8o1xk 124 61 , , , cord-297469-26d8o1xk 124 62 yellow yellow JJ cord-297469-26d8o1xk 124 63 fever fever NN cord-297469-26d8o1xk 124 64 , , , cord-297469-26d8o1xk 124 65 and and CC cord-297469-26d8o1xk 124 66 Ebola Ebola NNP cord-297469-26d8o1xk 124 67 , , , cord-297469-26d8o1xk 124 68 focusing focus VBG cord-297469-26d8o1xk 124 69 on on IN cord-297469-26d8o1xk 124 70 the the DT cord-297469-26d8o1xk 124 71 development development NN cord-297469-26d8o1xk 124 72 of of IN cord-297469-26d8o1xk 124 73 novel novel JJ cord-297469-26d8o1xk 124 74 drugs drug NNS cord-297469-26d8o1xk 124 75 and and CC cord-297469-26d8o1xk 124 76 effective effective JJ cord-297469-26d8o1xk 124 77 vaccine vaccine NN cord-297469-26d8o1xk 124 78 against against IN cord-297469-26d8o1xk 124 79 pathogens pathogen NNS cord-297469-26d8o1xk 124 80 . . . cord-297469-26d8o1xk 125 1 Furthermore furthermore RB cord-297469-26d8o1xk 125 2 , , , cord-297469-26d8o1xk 125 3 in in IN cord-297469-26d8o1xk 125 4 spite spite NN cord-297469-26d8o1xk 125 5 of of IN cord-297469-26d8o1xk 125 6 various various JJ cord-297469-26d8o1xk 125 7 efforts effort NNS cord-297469-26d8o1xk 125 8 for for IN cord-297469-26d8o1xk 125 9 developing develop VBG cord-297469-26d8o1xk 125 10 anti anti JJ cord-297469-26d8o1xk 125 11 - - JJ cord-297469-26d8o1xk 125 12 parasitic parasitic JJ cord-297469-26d8o1xk 125 13 drugs drug NNS cord-297469-26d8o1xk 125 14 against against IN cord-297469-26d8o1xk 125 15 zoonotic zoonotic JJ cord-297469-26d8o1xk 125 16 parasitosis parasitosis NN cord-297469-26d8o1xk 125 17 , , , cord-297469-26d8o1xk 125 18 effective effective JJ cord-297469-26d8o1xk 125 19 novel novel JJ cord-297469-26d8o1xk 125 20 drugs drug NNS cord-297469-26d8o1xk 125 21 such such JJ cord-297469-26d8o1xk 125 22 as as IN cord-297469-26d8o1xk 125 23 anti anti JJ cord-297469-26d8o1xk 125 24 - - JJ cord-297469-26d8o1xk 125 25 malaria malaria JJ cord-297469-26d8o1xk 125 26 drugs drug NNS cord-297469-26d8o1xk 125 27 have have VBP cord-297469-26d8o1xk 125 28 not not RB cord-297469-26d8o1xk 125 29 yet yet RB cord-297469-26d8o1xk 125 30 been be VBN cord-297469-26d8o1xk 125 31 developed develop VBN cord-297469-26d8o1xk 125 32 or or CC cord-297469-26d8o1xk 125 33 launched launch VBN cord-297469-26d8o1xk 125 34 . . . cord-297469-26d8o1xk 126 1 Many many JJ cord-297469-26d8o1xk 126 2 people people NNS cord-297469-26d8o1xk 126 3 are be VBP cord-297469-26d8o1xk 126 4 living live VBG cord-297469-26d8o1xk 126 5 with with IN cord-297469-26d8o1xk 126 6 animals animal NNS cord-297469-26d8o1xk 126 7 such such JJ cord-297469-26d8o1xk 126 8 as as IN cord-297469-26d8o1xk 126 9 cats cat NNS cord-297469-26d8o1xk 126 10 and and CC cord-297469-26d8o1xk 126 11 dogs dog NNS cord-297469-26d8o1xk 126 12 . . . cord-297469-26d8o1xk 127 1 In in IN cord-297469-26d8o1xk 127 2 particular particular JJ cord-297469-26d8o1xk 127 3 , , , cord-297469-26d8o1xk 127 4 toxoplasmosis toxoplasmosis NN cord-297469-26d8o1xk 127 5 , , , cord-297469-26d8o1xk 127 6 a a DT cord-297469-26d8o1xk 127 7 zoonotic zoonotic JJ cord-297469-26d8o1xk 127 8 parasitosis parasitosis NN cord-297469-26d8o1xk 127 9 , , , cord-297469-26d8o1xk 127 10 is be VBZ cord-297469-26d8o1xk 127 11 transmitted transmit VBN cord-297469-26d8o1xk 127 12 via via IN cord-297469-26d8o1xk 127 13 physical physical JJ cord-297469-26d8o1xk 127 14 contact contact NN cord-297469-26d8o1xk 127 15 with with IN cord-297469-26d8o1xk 127 16 pets pet NNS cord-297469-26d8o1xk 127 17 and and CC cord-297469-26d8o1xk 127 18 companion companion NN cord-297469-26d8o1xk 127 19 animals animal NNS cord-297469-26d8o1xk 127 20 , , , cord-297469-26d8o1xk 127 21 including include VBG cord-297469-26d8o1xk 127 22 cat cat NN cord-297469-26d8o1xk 127 23 and and CC cord-297469-26d8o1xk 127 24 dogs dog NNS cord-297469-26d8o1xk 127 25 . . . cord-297469-26d8o1xk 128 1 With with IN cord-297469-26d8o1xk 128 2 respect respect NN cord-297469-26d8o1xk 128 3 to to IN cord-297469-26d8o1xk 128 4 these these DT cord-297469-26d8o1xk 128 5 aspects aspect NNS cord-297469-26d8o1xk 128 6 , , , cord-297469-26d8o1xk 128 7 we -PRON- PRP cord-297469-26d8o1xk 128 8 carefully carefully RB cord-297469-26d8o1xk 128 9 focused focus VBD cord-297469-26d8o1xk 128 10 on on IN cord-297469-26d8o1xk 128 11 the the DT cord-297469-26d8o1xk 128 12 parasitic parasitic JJ cord-297469-26d8o1xk 128 13 infectious infectious JJ cord-297469-26d8o1xk 128 14 diseases disease NNS cord-297469-26d8o1xk 128 15 that that WDT cord-297469-26d8o1xk 128 16 are be VBP cord-297469-26d8o1xk 128 17 consistently consistently RB cord-297469-26d8o1xk 128 18 caused cause VBN cord-297469-26d8o1xk 128 19 through through IN cord-297469-26d8o1xk 128 20 various various JJ cord-297469-26d8o1xk 128 21 infection infection NN cord-297469-26d8o1xk 128 22 pathways pathway NNS cord-297469-26d8o1xk 128 23 and and CC cord-297469-26d8o1xk 128 24 factors factor NNS cord-297469-26d8o1xk 128 25 . . . cord-297469-26d8o1xk 129 1 Among among IN cord-297469-26d8o1xk 129 2 various various JJ cord-297469-26d8o1xk 129 3 parasites parasite NNS cord-297469-26d8o1xk 129 4 , , , cord-297469-26d8o1xk 129 5 T. T. NNP cord-297469-26d8o1xk 129 6 gondii gondii NNP cord-297469-26d8o1xk 129 7 induces induce VBZ cord-297469-26d8o1xk 129 8 serious serious JJ cord-297469-26d8o1xk 129 9 symptoms symptom NNS cord-297469-26d8o1xk 129 10 such such JJ cord-297469-26d8o1xk 129 11 as as IN cord-297469-26d8o1xk 129 12 cerebral cerebral JJ cord-297469-26d8o1xk 129 13 calcification calcification NN cord-297469-26d8o1xk 129 14 and and CC cord-297469-26d8o1xk 129 15 meningoencephalitis meningoencephalitis NN cord-297469-26d8o1xk 129 16 in in IN cord-297469-26d8o1xk 129 17 the the DT cord-297469-26d8o1xk 129 18 brain brain NN cord-297469-26d8o1xk 129 19 , , , cord-297469-26d8o1xk 129 20 while while IN cord-297469-26d8o1xk 129 21 causing cause VBG cord-297469-26d8o1xk 129 22 fetal fetal JJ cord-297469-26d8o1xk 129 23 infection infection NN cord-297469-26d8o1xk 129 24 through through IN cord-297469-26d8o1xk 129 25 mother mother NN cord-297469-26d8o1xk 129 26 during during IN cord-297469-26d8o1xk 129 27 pregnancy pregnancy NN cord-297469-26d8o1xk 129 28 , , , cord-297469-26d8o1xk 129 29 as as IN cord-297469-26d8o1xk 129 30 it -PRON- PRP cord-297469-26d8o1xk 129 31 is be VBZ cord-297469-26d8o1xk 129 32 a a DT cord-297469-26d8o1xk 129 33 zoonotic zoonotic JJ cord-297469-26d8o1xk 129 34 parasite parasite NN cord-297469-26d8o1xk 129 35 which which WDT cord-297469-26d8o1xk 129 36 affects affect VBZ cord-297469-26d8o1xk 129 37 both both DT cord-297469-26d8o1xk 129 38 humans human NNS cord-297469-26d8o1xk 129 39 and and CC cord-297469-26d8o1xk 129 40 animals animal NNS cord-297469-26d8o1xk 129 41 , , , cord-297469-26d8o1xk 129 42 resulting result VBG cord-297469-26d8o1xk 129 43 in in IN cord-297469-26d8o1xk 129 44 parasitic parasitic JJ cord-297469-26d8o1xk 129 45 diseases disease NNS cord-297469-26d8o1xk 129 46 such such JJ cord-297469-26d8o1xk 129 47 as as IN cord-297469-26d8o1xk 129 48 toxoplasmosis toxoplasmosi NNS cord-297469-26d8o1xk 129 49 [ [ -LRB- cord-297469-26d8o1xk 129 50 49 49 CD cord-297469-26d8o1xk 129 51 , , , cord-297469-26d8o1xk 129 52 50 50 CD cord-297469-26d8o1xk 129 53 ] ] -RRB- cord-297469-26d8o1xk 129 54 . . . cord-297469-26d8o1xk 130 1 Furthermore furthermore RB cord-297469-26d8o1xk 130 2 , , , cord-297469-26d8o1xk 130 3 it -PRON- PRP cord-297469-26d8o1xk 130 4 induces induce VBZ cord-297469-26d8o1xk 130 5 serious serious JJ cord-297469-26d8o1xk 130 6 complications complication NNS cord-297469-26d8o1xk 130 7 in in IN cord-297469-26d8o1xk 130 8 immune immune NN cord-297469-26d8o1xk 130 9 - - HYPH cord-297469-26d8o1xk 130 10 deficient deficient JJ cord-297469-26d8o1xk 130 11 patients patient NNS cord-297469-26d8o1xk 130 12 and and CC cord-297469-26d8o1xk 130 13 HIV HIV NNP cord-297469-26d8o1xk 130 14 patients patient NNS cord-297469-26d8o1xk 130 15 , , , cord-297469-26d8o1xk 130 16 which which WDT cord-297469-26d8o1xk 130 17 attenuates attenuate VBZ cord-297469-26d8o1xk 130 18 the the DT cord-297469-26d8o1xk 130 19 interaction interaction NN cord-297469-26d8o1xk 130 20 of of IN cord-297469-26d8o1xk 130 21 the the DT cord-297469-26d8o1xk 130 22 immune immune JJ cord-297469-26d8o1xk 130 23 system system NN cord-297469-26d8o1xk 130 24 that that WDT cord-297469-26d8o1xk 130 25 specifically specifically RB cord-297469-26d8o1xk 130 26 responds respond VBZ cord-297469-26d8o1xk 130 27 to to IN cord-297469-26d8o1xk 130 28 pathogens pathogen NNS cord-297469-26d8o1xk 130 29 in in IN cord-297469-26d8o1xk 130 30 the the DT cord-297469-26d8o1xk 130 31 host host NN cord-297469-26d8o1xk 130 32 [ [ -LRB- cord-297469-26d8o1xk 130 33 51 51 CD cord-297469-26d8o1xk 130 34 , , , cord-297469-26d8o1xk 130 35 52 52 CD cord-297469-26d8o1xk 130 36 ] ] -RRB- cord-297469-26d8o1xk 130 37 . . . cord-297469-26d8o1xk 131 1 T. T. NNP cord-297469-26d8o1xk 131 2 gondii gondii NNP cord-297469-26d8o1xk 131 3 inhibits inhibit VBZ cord-297469-26d8o1xk 131 4 the the DT cord-297469-26d8o1xk 131 5 interaction interaction NN cord-297469-26d8o1xk 131 6 of of IN cord-297469-26d8o1xk 131 7 cytokines cytokine NNS cord-297469-26d8o1xk 131 8 such such JJ cord-297469-26d8o1xk 131 9 as as IN cord-297469-26d8o1xk 131 10 IL-4 IL-4 NNP cord-297469-26d8o1xk 131 11 and and CC cord-297469-26d8o1xk 131 12 IFN IFN NNP cord-297469-26d8o1xk 131 13 - - HYPH cord-297469-26d8o1xk 131 14 γ γ NNP cord-297469-26d8o1xk 131 15 that that WDT cord-297469-26d8o1xk 131 16 are be VBP cord-297469-26d8o1xk 131 17 activated activate VBN cord-297469-26d8o1xk 131 18 through through IN cord-297469-26d8o1xk 131 19 the the DT cord-297469-26d8o1xk 131 20 immune immune JJ cord-297469-26d8o1xk 131 21 system system NN cord-297469-26d8o1xk 131 22 , , , cord-297469-26d8o1xk 131 23 attenuating attenuate VBG cord-297469-26d8o1xk 131 24 the the DT cord-297469-26d8o1xk 131 25 production production NN cord-297469-26d8o1xk 131 26 of of IN cord-297469-26d8o1xk 131 27 cytokines cytokine NNS cord-297469-26d8o1xk 131 28 from from IN cord-297469-26d8o1xk 131 29 host host NN cord-297469-26d8o1xk 131 30 cells cell NNS cord-297469-26d8o1xk 131 31 . . . cord-297469-26d8o1xk 132 1 In in IN cord-297469-26d8o1xk 132 2 addition addition NN cord-297469-26d8o1xk 132 3 , , , cord-297469-26d8o1xk 132 4 it -PRON- PRP cord-297469-26d8o1xk 132 5 is be VBZ cord-297469-26d8o1xk 132 6 known know VBN cord-297469-26d8o1xk 132 7 that that IN cord-297469-26d8o1xk 132 8 T. t. NN cord-297469-26d8o1xk 132 9 gondii gondii NN cord-297469-26d8o1xk 132 10 blocks block VBZ cord-297469-26d8o1xk 132 11 parasitic parasitic JJ cord-297469-26d8o1xk 132 12 inhibitory inhibitory JJ cord-297469-26d8o1xk 132 13 system system NN cord-297469-26d8o1xk 132 14 while while IN cord-297469-26d8o1xk 132 15 inhibiting inhibit VBG cord-297469-26d8o1xk 132 16 the the DT cord-297469-26d8o1xk 132 17 signal signal JJ cord-297469-26d8o1xk 132 18 pathways pathway NNS cord-297469-26d8o1xk 132 19 of of IN cord-297469-26d8o1xk 132 20 cell cell NN cord-297469-26d8o1xk 132 21 cycle cycle NN cord-297469-26d8o1xk 132 22 initiators initiator NNS cord-297469-26d8o1xk 132 23 or or CC cord-297469-26d8o1xk 132 24 apoptotic apoptotic JJ cord-297469-26d8o1xk 132 25 mediators mediator NNS cord-297469-26d8o1xk 132 26 for for IN cord-297469-26d8o1xk 132 27 the the DT cord-297469-26d8o1xk 132 28 apoptotic apoptotic JJ cord-297469-26d8o1xk 132 29 stage stage NN cord-297469-26d8o1xk 132 30 in in IN cord-297469-26d8o1xk 132 31 host host NN cord-297469-26d8o1xk 132 32 cells cell NNS cord-297469-26d8o1xk 132 33 after after IN cord-297469-26d8o1xk 132 34 invasion invasion NN cord-297469-26d8o1xk 132 35 [ [ -LRB- cord-297469-26d8o1xk 132 36 53 53 CD cord-297469-26d8o1xk 132 37 , , , cord-297469-26d8o1xk 132 38 54 54 CD cord-297469-26d8o1xk 132 39 ] ] -RRB- cord-297469-26d8o1xk 132 40 . . . cord-297469-26d8o1xk 133 1 T. t. XX cord-297469-26d8o1xk 133 2 gondii gondii NNP cord-297469-26d8o1xk 133 3 infection infection NN cord-297469-26d8o1xk 133 4 induces induce VBZ cord-297469-26d8o1xk 133 5 an an DT cord-297469-26d8o1xk 133 6 imbalance imbalance NN cord-297469-26d8o1xk 133 7 of of IN cord-297469-26d8o1xk 133 8 immune immune JJ cord-297469-26d8o1xk 133 9 response response NN cord-297469-26d8o1xk 133 10 by by IN cord-297469-26d8o1xk 133 11 causing cause VBG cord-297469-26d8o1xk 133 12 changes change NNS cord-297469-26d8o1xk 133 13 in in IN cord-297469-26d8o1xk 133 14 cytokines cytokine NNS cord-297469-26d8o1xk 133 15 such such JJ cord-297469-26d8o1xk 133 16 as as IN cord-297469-26d8o1xk 133 17 TNF TNF NNP cord-297469-26d8o1xk 133 18 - - HYPH cord-297469-26d8o1xk 133 19 α α NNP cord-297469-26d8o1xk 133 20 and and CC cord-297469-26d8o1xk 133 21 TGF TGF NNP cord-297469-26d8o1xk 133 22 - - HYPH cord-297469-26d8o1xk 133 23 β1 β1 NNP cord-297469-26d8o1xk 133 24 in in IN cord-297469-26d8o1xk 133 25 the the DT cord-297469-26d8o1xk 133 26 host host NN cord-297469-26d8o1xk 133 27 , , , cord-297469-26d8o1xk 133 28 resulting result VBG cord-297469-26d8o1xk 133 29 in in IN cord-297469-26d8o1xk 133 30 immune immune JJ cord-297469-26d8o1xk 133 31 deficiency deficiency NN cord-297469-26d8o1xk 133 32 by by IN cord-297469-26d8o1xk 133 33 breaking break VBG cord-297469-26d8o1xk 133 34 homeostasis homeostasis NN cord-297469-26d8o1xk 133 35 and and CC cord-297469-26d8o1xk 133 36 interaction interaction NN cord-297469-26d8o1xk 133 37 of of IN cord-297469-26d8o1xk 133 38 the the DT cord-297469-26d8o1xk 133 39 immune immune JJ cord-297469-26d8o1xk 133 40 system system NN cord-297469-26d8o1xk 133 41 in in IN cord-297469-26d8o1xk 133 42 the the DT cord-297469-26d8o1xk 133 43 host host NN cord-297469-26d8o1xk 133 44 . . . cord-297469-26d8o1xk 134 1 Moreover moreover RB cord-297469-26d8o1xk 134 2 , , , cord-297469-26d8o1xk 134 3 T. T. NNP cord-297469-26d8o1xk 134 4 gondii gondii NNP cord-297469-26d8o1xk 134 5 induces induce VBZ cord-297469-26d8o1xk 134 6 the the DT cord-297469-26d8o1xk 134 7 proliferative proliferative JJ cord-297469-26d8o1xk 134 8 and and CC cord-297469-26d8o1xk 134 9 growth growth NN cord-297469-26d8o1xk 134 10 cycle cycle NN cord-297469-26d8o1xk 134 11 of of IN cord-297469-26d8o1xk 134 12 T. t. NN cord-297469-26d8o1xk 134 13 gondii gondii NN cord-297469-26d8o1xk 134 14 by by IN cord-297469-26d8o1xk 134 15 rapidly rapidly RB cord-297469-26d8o1xk 134 16 forming form VBG cord-297469-26d8o1xk 134 17 PVM PVM NNP cord-297469-26d8o1xk 134 18 and and CC cord-297469-26d8o1xk 134 19 by by IN cord-297469-26d8o1xk 134 20 regulating regulate VBG cord-297469-26d8o1xk 134 21 cell cell NN cord-297469-26d8o1xk 134 22 cycle cycle NN cord-297469-26d8o1xk 134 23 factors factor NNS cord-297469-26d8o1xk 134 24 for for IN cord-297469-26d8o1xk 134 25 its -PRON- PRP$ cord-297469-26d8o1xk 134 26 survival survival NN cord-297469-26d8o1xk 134 27 in in IN cord-297469-26d8o1xk 134 28 host host NN cord-297469-26d8o1xk 134 29 cells cell NNS cord-297469-26d8o1xk 134 30 , , , cord-297469-26d8o1xk 134 31 maintaining maintain VBG cord-297469-26d8o1xk 134 32 the the DT cord-297469-26d8o1xk 134 33 survival survival NN cord-297469-26d8o1xk 134 34 by by IN cord-297469-26d8o1xk 134 35 accelerating accelerate VBG cord-297469-26d8o1xk 134 36 the the DT cord-297469-26d8o1xk 134 37 proliferation proliferation NN cord-297469-26d8o1xk 134 38 of of IN cord-297469-26d8o1xk 134 39 T. t. NN cord-297469-26d8o1xk 134 40 gondii gondii NN cord-297469-26d8o1xk 134 41 in in IN cord-297469-26d8o1xk 134 42 host host NN cord-297469-26d8o1xk 134 43 [ [ -LRB- cord-297469-26d8o1xk 134 44 55 55 CD cord-297469-26d8o1xk 134 45 , , , cord-297469-26d8o1xk 134 46 56 56 CD cord-297469-26d8o1xk 134 47 ] ] -RRB- cord-297469-26d8o1xk 134 48 . . . cord-297469-26d8o1xk 135 1 The the DT cord-297469-26d8o1xk 135 2 subcellular subcellular JJ cord-297469-26d8o1xk 135 3 organelles organelle NNS cord-297469-26d8o1xk 135 4 and and CC cord-297469-26d8o1xk 135 5 granules granule NNS cord-297469-26d8o1xk 135 6 of of IN cord-297469-26d8o1xk 135 7 T. t. NN cord-297469-26d8o1xk 135 8 gondii gondii NN cord-297469-26d8o1xk 135 9 , , , cord-297469-26d8o1xk 135 10 such such JJ cord-297469-26d8o1xk 135 11 as as IN cord-297469-26d8o1xk 135 12 the the DT cord-297469-26d8o1xk 135 13 conoid conoid NN cord-297469-26d8o1xk 135 14 , , , cord-297469-26d8o1xk 135 15 GRAs gra NNS cord-297469-26d8o1xk 135 16 , , , cord-297469-26d8o1xk 135 17 SAGs sag NNS cord-297469-26d8o1xk 135 18 , , , cord-297469-26d8o1xk 135 19 the the DT cord-297469-26d8o1xk 135 20 rhoptry rhoptry NN cord-297469-26d8o1xk 135 21 , , , cord-297469-26d8o1xk 135 22 microneme microneme NN cord-297469-26d8o1xk 135 23 proteins protein NNS cord-297469-26d8o1xk 135 24 , , , cord-297469-26d8o1xk 135 25 and and CC cord-297469-26d8o1xk 135 26 the the DT cord-297469-26d8o1xk 135 27 inner inner JJ cord-297469-26d8o1xk 135 28 membrane membrane NN cord-297469-26d8o1xk 135 29 complex complex NN cord-297469-26d8o1xk 135 30 , , , cord-297469-26d8o1xk 135 31 were be VBD cord-297469-26d8o1xk 135 32 focused focus VBN cord-297469-26d8o1xk 135 33 upon upon IN cord-297469-26d8o1xk 135 34 as as IN cord-297469-26d8o1xk 135 35 major major JJ cord-297469-26d8o1xk 135 36 targets target NNS cord-297469-26d8o1xk 135 37 for for IN cord-297469-26d8o1xk 135 38 blocking block VBG cord-297469-26d8o1xk 135 39 T. t. NN cord-297469-26d8o1xk 135 40 gondii gondii NN cord-297469-26d8o1xk 135 41 infection infection NN cord-297469-26d8o1xk 135 42 , , , cord-297469-26d8o1xk 135 43 which which WDT cord-297469-26d8o1xk 135 44 was be VBD cord-297469-26d8o1xk 135 45 used use VBN cord-297469-26d8o1xk 135 46 as as IN cord-297469-26d8o1xk 135 47 major major JJ cord-297469-26d8o1xk 135 48 recombinant recombinant JJ cord-297469-26d8o1xk 135 49 proteins protein NNS cord-297469-26d8o1xk 135 50 or or CC cord-297469-26d8o1xk 135 51 factors factor NNS cord-297469-26d8o1xk 135 52 for for IN cord-297469-26d8o1xk 135 53 protective protective JJ cord-297469-26d8o1xk 135 54 immunity immunity NN cord-297469-26d8o1xk 135 55 including include VBG cord-297469-26d8o1xk 135 56 vaccination vaccination NN cord-297469-26d8o1xk 135 57 [ [ -LRB- cord-297469-26d8o1xk 135 58 57 57 CD cord-297469-26d8o1xk 135 59 ] ] -RRB- cord-297469-26d8o1xk 135 60 [ [ -LRB- cord-297469-26d8o1xk 135 61 58 58 CD cord-297469-26d8o1xk 135 62 ] ] -RRB- cord-297469-26d8o1xk 135 63 [ [ -LRB- cord-297469-26d8o1xk 135 64 59 59 CD cord-297469-26d8o1xk 135 65 ] ] -RRB- cord-297469-26d8o1xk 135 66 [ [ -LRB- cord-297469-26d8o1xk 135 67 60 60 CD cord-297469-26d8o1xk 135 68 ] ] -RRB- cord-297469-26d8o1xk 135 69 . . . cord-297469-26d8o1xk 136 1 For for IN cord-297469-26d8o1xk 136 2 these these DT cord-297469-26d8o1xk 136 3 reasons reason NNS cord-297469-26d8o1xk 136 4 , , , cord-297469-26d8o1xk 136 5 in in IN cord-297469-26d8o1xk 136 6 this this DT cord-297469-26d8o1xk 136 7 study study NN cord-297469-26d8o1xk 136 8 we -PRON- PRP cord-297469-26d8o1xk 136 9 not not RB cord-297469-26d8o1xk 136 10 only only RB cord-297469-26d8o1xk 136 11 evaluated evaluate VBD cord-297469-26d8o1xk 136 12 the the DT cord-297469-26d8o1xk 136 13 anti anti JJ cord-297469-26d8o1xk 136 14 - - JJ cord-297469-26d8o1xk 136 15 parasitic parasitic JJ cord-297469-26d8o1xk 136 16 effect effect NN cord-297469-26d8o1xk 136 17 of of IN cord-297469-26d8o1xk 136 18 UA UA NNP cord-297469-26d8o1xk 136 19 which which WDT cord-297469-26d8o1xk 136 20 inhibits inhibit VBZ cord-297469-26d8o1xk 136 21 the the DT cord-297469-26d8o1xk 136 22 survival survival NN cord-297469-26d8o1xk 136 23 of of IN cord-297469-26d8o1xk 136 24 parasite parasite NN cord-297469-26d8o1xk 136 25 after after IN cord-297469-26d8o1xk 136 26 T. t. NN cord-297469-26d8o1xk 136 27 gondii gondii NN cord-297469-26d8o1xk 136 28 infection infection NN cord-297469-26d8o1xk 136 29 through through IN cord-297469-26d8o1xk 136 30 a a DT cord-297469-26d8o1xk 136 31 T. T. NNP cord-297469-26d8o1xk 136 32 gondii gondii NN cord-297469-26d8o1xk 136 33 - - HYPH cord-297469-26d8o1xk 136 34 infected infect VBN cord-297469-26d8o1xk 136 35 co co JJ cord-297469-26d8o1xk 136 36 - - JJ cord-297469-26d8o1xk 136 37 cultured cultured JJ cord-297469-26d8o1xk 136 38 immune immune JJ cord-297469-26d8o1xk 136 39 system system NN cord-297469-26d8o1xk 136 40 , , , cord-297469-26d8o1xk 136 41 but but CC cord-297469-26d8o1xk 136 42 also also RB cord-297469-26d8o1xk 136 43 confirmed confirm VBD cord-297469-26d8o1xk 136 44 its -PRON- PRP$ cord-297469-26d8o1xk 136 45 mechanism mechanism NN cord-297469-26d8o1xk 136 46 of of IN cord-297469-26d8o1xk 136 47 action action NN cord-297469-26d8o1xk 136 48 with with IN cord-297469-26d8o1xk 136 49 respect respect NN cord-297469-26d8o1xk 136 50 to to IN cord-297469-26d8o1xk 136 51 anti anti JJ cord-297469-26d8o1xk 136 52 - - JJ cord-297469-26d8o1xk 136 53 T. t. JJ cord-297469-26d8o1xk 136 54 gondii gondii NN cord-297469-26d8o1xk 136 55 effects effect NNS cord-297469-26d8o1xk 136 56 and and CC cord-297469-26d8o1xk 136 57 immunomodulatory immunomodulatory JJ cord-297469-26d8o1xk 136 58 activity activity NN cord-297469-26d8o1xk 136 59 . . . cord-297469-26d8o1xk 137 1 In in IN cord-297469-26d8o1xk 137 2 the the DT cord-297469-26d8o1xk 137 3 present present JJ cord-297469-26d8o1xk 137 4 study study NN cord-297469-26d8o1xk 137 5 , , , cord-297469-26d8o1xk 137 6 the the DT cord-297469-26d8o1xk 137 7 survival survival NN cord-297469-26d8o1xk 137 8 rates rate NNS cord-297469-26d8o1xk 137 9 of of IN cord-297469-26d8o1xk 137 10 T. t. NN cord-297469-26d8o1xk 137 11 gondii gondii NNS cord-297469-26d8o1xk 137 12 were be VBD cord-297469-26d8o1xk 137 13 markedly markedly RB cord-297469-26d8o1xk 137 14 inhibited inhibit VBN cord-297469-26d8o1xk 137 15 when when WRB cord-297469-26d8o1xk 137 16 the the DT cord-297469-26d8o1xk 137 17 parasites parasite NNS cord-297469-26d8o1xk 137 18 were be VBD cord-297469-26d8o1xk 137 19 treated treat VBN cord-297469-26d8o1xk 137 20 with with IN cord-297469-26d8o1xk 137 21 UA UA NNP cord-297469-26d8o1xk 137 22 and and CC cord-297469-26d8o1xk 137 23 SF SF NNP cord-297469-26d8o1xk 137 24 compared compare VBN cord-297469-26d8o1xk 137 25 with with IN cord-297469-26d8o1xk 137 26 the the DT cord-297469-26d8o1xk 137 27 non non JJ cord-297469-26d8o1xk 137 28 - - JJ cord-297469-26d8o1xk 137 29 treated treat VBN cord-297469-26d8o1xk 137 30 T. t. NN cord-297469-26d8o1xk 137 31 gondii gondii NNP cord-297469-26d8o1xk 137 32 group group NN cord-297469-26d8o1xk 137 33 , , , cord-297469-26d8o1xk 137 34 and and CC cord-297469-26d8o1xk 137 35 the the DT cord-297469-26d8o1xk 137 36 expression expression NN cord-297469-26d8o1xk 137 37 of of IN cord-297469-26d8o1xk 137 38 subcellular subcellular JJ cord-297469-26d8o1xk 137 39 organelles organelle NNS cord-297469-26d8o1xk 137 40 and and CC cord-297469-26d8o1xk 137 41 granules granule NNS cord-297469-26d8o1xk 137 42 of of IN cord-297469-26d8o1xk 137 43 T. t. NN cord-297469-26d8o1xk 137 44 gondii gondii NN cord-297469-26d8o1xk 137 45 in in IN cord-297469-26d8o1xk 137 46 the the DT cord-297469-26d8o1xk 137 47 infected infected JJ cord-297469-26d8o1xk 137 48 cells cell NNS cord-297469-26d8o1xk 137 49 was be VBD cord-297469-26d8o1xk 137 50 effectively effectively RB cord-297469-26d8o1xk 137 51 decreased decrease VBN cord-297469-26d8o1xk 137 52 in in IN cord-297469-26d8o1xk 137 53 T. T. NNP cord-297469-26d8o1xk 137 54 gondii gondii NN cord-297469-26d8o1xk 137 55 - - HYPH cord-297469-26d8o1xk 137 56 infected infect VBN cord-297469-26d8o1xk 137 57 group group NN cord-297469-26d8o1xk 137 58 treated treat VBN cord-297469-26d8o1xk 137 59 with with IN cord-297469-26d8o1xk 137 60 UA UA NNP cord-297469-26d8o1xk 137 61 compared compare VBN cord-297469-26d8o1xk 137 62 with with IN cord-297469-26d8o1xk 137 63 other other JJ cord-297469-26d8o1xk 137 64 groups group NNS cord-297469-26d8o1xk 137 65 . . . cord-297469-26d8o1xk 138 1 Furthermore furthermore RB cord-297469-26d8o1xk 138 2 , , , cord-297469-26d8o1xk 138 3 the the DT cord-297469-26d8o1xk 138 4 production production NN cord-297469-26d8o1xk 138 5 of of IN cord-297469-26d8o1xk 138 6 ROS ROS NNP cord-297469-26d8o1xk 138 7 and and CC cord-297469-26d8o1xk 138 8 NO no UH cord-297469-26d8o1xk 138 9 was be VBD cord-297469-26d8o1xk 138 10 significantly significantly RB cord-297469-26d8o1xk 138 11 increased increase VBN cord-297469-26d8o1xk 138 12 in in IN cord-297469-26d8o1xk 138 13 the the DT cord-297469-26d8o1xk 138 14 T. T. NNP cord-297469-26d8o1xk 138 15 gondii gondii NN cord-297469-26d8o1xk 138 16 - - HYPH cord-297469-26d8o1xk 138 17 infected infect VBN cord-297469-26d8o1xk 138 18 group group NN cord-297469-26d8o1xk 138 19 treated treat VBN cord-297469-26d8o1xk 138 20 with with IN cord-297469-26d8o1xk 138 21 UA UA NNP cord-297469-26d8o1xk 138 22 compared compare VBN cord-297469-26d8o1xk 138 23 with with IN cord-297469-26d8o1xk 138 24 both both DT cord-297469-26d8o1xk 138 25 SF SF NNP cord-297469-26d8o1xk 138 26 - - HYPH cord-297469-26d8o1xk 138 27 treated treat VBN cord-297469-26d8o1xk 138 28 and and CC cord-297469-26d8o1xk 138 29 infection infection NN cord-297469-26d8o1xk 138 30 groups group NNS cord-297469-26d8o1xk 138 31 . . . cord-297469-26d8o1xk 139 1 Interestingly interestingly RB cord-297469-26d8o1xk 139 2 , , , cord-297469-26d8o1xk 139 3 although although IN cord-297469-26d8o1xk 139 4 ROS ROS NNP cord-297469-26d8o1xk 139 5 production production NN cord-297469-26d8o1xk 139 6 was be VBD cord-297469-26d8o1xk 139 7 activated activate VBN cord-297469-26d8o1xk 139 8 in in IN cord-297469-26d8o1xk 139 9 both both CC cord-297469-26d8o1xk 139 10 T. T. NNP cord-297469-26d8o1xk 139 11 gondii gondii NN cord-297469-26d8o1xk 139 12 - - HYPH cord-297469-26d8o1xk 139 13 infected infect VBN cord-297469-26d8o1xk 139 14 cells cell NNS cord-297469-26d8o1xk 139 15 treated treat VBN cord-297469-26d8o1xk 139 16 with with IN cord-297469-26d8o1xk 139 17 UA UA NNP cord-297469-26d8o1xk 139 18 and and CC cord-297469-26d8o1xk 139 19 SF SF NNP cord-297469-26d8o1xk 139 20 , , , cord-297469-26d8o1xk 139 21 its -PRON- PRP$ cord-297469-26d8o1xk 139 22 rate rate NN cord-297469-26d8o1xk 139 23 was be VBD cord-297469-26d8o1xk 139 24 gradually gradually RB cord-297469-26d8o1xk 139 25 decreased decrease VBN cord-297469-26d8o1xk 139 26 in in IN cord-297469-26d8o1xk 139 27 the the DT cord-297469-26d8o1xk 139 28 range range NN cord-297469-26d8o1xk 139 29 of of IN cord-297469-26d8o1xk 139 30 high high JJ cord-297469-26d8o1xk 139 31 concentrations concentration NNS cord-297469-26d8o1xk 139 32 of of IN cord-297469-26d8o1xk 139 33 the the DT cord-297469-26d8o1xk 139 34 compounds compound NNS cord-297469-26d8o1xk 139 35 . . . cord-297469-26d8o1xk 140 1 In in IN cord-297469-26d8o1xk 140 2 these these DT cord-297469-26d8o1xk 140 3 aspects aspect NNS cord-297469-26d8o1xk 140 4 , , , cord-297469-26d8o1xk 140 5 NO NO NNP cord-297469-26d8o1xk 140 6 and and CC cord-297469-26d8o1xk 140 7 ROS ROS NNP cord-297469-26d8o1xk 140 8 production production NN cord-297469-26d8o1xk 140 9 not not RB cord-297469-26d8o1xk 140 10 only only RB cord-297469-26d8o1xk 140 11 activates activate VBZ cord-297469-26d8o1xk 140 12 immune immune JJ cord-297469-26d8o1xk 140 13 defense defense NN cord-297469-26d8o1xk 140 14 systems system NNS cord-297469-26d8o1xk 140 15 against against IN cord-297469-26d8o1xk 140 16 various various JJ cord-297469-26d8o1xk 140 17 pathogens pathogen NNS cord-297469-26d8o1xk 140 18 such such JJ cord-297469-26d8o1xk 140 19 as as IN cord-297469-26d8o1xk 140 20 bacteria bacteria NNS cord-297469-26d8o1xk 140 21 and and CC cord-297469-26d8o1xk 140 22 viruses virus NNS cord-297469-26d8o1xk 140 23 but but CC cord-297469-26d8o1xk 140 24 also also RB cord-297469-26d8o1xk 140 25 maintains maintain VBZ cord-297469-26d8o1xk 140 26 effectively effectively RB cord-297469-26d8o1xk 140 27 the the DT cord-297469-26d8o1xk 140 28 changes change NNS cord-297469-26d8o1xk 140 29 of of IN cord-297469-26d8o1xk 140 30 the the DT cord-297469-26d8o1xk 140 31 homeostasis homeostasis NN cord-297469-26d8o1xk 140 32 in in IN cord-297469-26d8o1xk 140 33 the the DT cord-297469-26d8o1xk 140 34 organism organism NN cord-297469-26d8o1xk 140 35 , , , cord-297469-26d8o1xk 140 36 promoting promote VBG cord-297469-26d8o1xk 140 37 the the DT cord-297469-26d8o1xk 140 38 production production NN cord-297469-26d8o1xk 140 39 of of IN cord-297469-26d8o1xk 140 40 cytokines cytokine NNS cord-297469-26d8o1xk 140 41 induced induce VBN cord-297469-26d8o1xk 140 42 by by IN cord-297469-26d8o1xk 140 43 the the DT cord-297469-26d8o1xk 140 44 interaction interaction NN cord-297469-26d8o1xk 140 45 of of IN cord-297469-26d8o1xk 140 46 immune immune JJ cord-297469-26d8o1xk 140 47 cells cell NNS cord-297469-26d8o1xk 140 48 . . . cord-297469-26d8o1xk 141 1 Cytokines cytokine NNS cord-297469-26d8o1xk 141 2 such such JJ cord-297469-26d8o1xk 141 3 as as IN cord-297469-26d8o1xk 141 4 IL-1β IL-1β NNP cord-297469-26d8o1xk 141 5 , , , cord-297469-26d8o1xk 141 6 IL-6 IL-6 NNP cord-297469-26d8o1xk 141 7 , , , cord-297469-26d8o1xk 141 8 and and CC cord-297469-26d8o1xk 141 9 TNF TNF NNP cord-297469-26d8o1xk 141 10 - - HYPH cord-297469-26d8o1xk 141 11 α α NNP cord-297469-26d8o1xk 141 12 were be VBD cord-297469-26d8o1xk 141 13 increased increase VBN cord-297469-26d8o1xk 141 14 in in IN cord-297469-26d8o1xk 141 15 the the DT cord-297469-26d8o1xk 141 16 infected infected JJ cord-297469-26d8o1xk 141 17 cells cell NNS cord-297469-26d8o1xk 141 18 after after IN cord-297469-26d8o1xk 141 19 T. t. NN cord-297469-26d8o1xk 141 20 gondii gondii NN cord-297469-26d8o1xk 141 21 infection infection NN cord-297469-26d8o1xk 141 22 , , , cord-297469-26d8o1xk 141 23 and and CC cord-297469-26d8o1xk 141 24 their -PRON- PRP$ cord-297469-26d8o1xk 141 25 production production NN cord-297469-26d8o1xk 141 26 was be VBD cord-297469-26d8o1xk 141 27 significantly significantly RB cord-297469-26d8o1xk 141 28 suppressed suppress VBN cord-297469-26d8o1xk 141 29 after after IN cord-297469-26d8o1xk 141 30 UA UA NNP cord-297469-26d8o1xk 141 31 treatment treatment NN cord-297469-26d8o1xk 141 32 . . . cord-297469-26d8o1xk 142 1 In in IN cord-297469-26d8o1xk 142 2 particular particular JJ cord-297469-26d8o1xk 142 3 , , , cord-297469-26d8o1xk 142 4 although although IN cord-297469-26d8o1xk 142 5 the the DT cord-297469-26d8o1xk 142 6 production production NN cord-297469-26d8o1xk 142 7 of of IN cord-297469-26d8o1xk 142 8 TGF TGF NNP cord-297469-26d8o1xk 142 9 - - HYPH cord-297469-26d8o1xk 142 10 β1 β1 NNP cord-297469-26d8o1xk 142 11 was be VBD cord-297469-26d8o1xk 142 12 reduced reduce VBN cord-297469-26d8o1xk 142 13 in in IN cord-297469-26d8o1xk 142 14 T. T. NNP cord-297469-26d8o1xk 142 15 gondii gondii NN cord-297469-26d8o1xk 142 16 - - HYPH cord-297469-26d8o1xk 142 17 infected infect VBN cord-297469-26d8o1xk 142 18 immune immune JJ cord-297469-26d8o1xk 142 19 cells cell NNS cord-297469-26d8o1xk 142 20 treated treat VBN cord-297469-26d8o1xk 142 21 with with IN cord-297469-26d8o1xk 142 22 UA UA NNP cord-297469-26d8o1xk 142 23 , , , cord-297469-26d8o1xk 142 24 it -PRON- PRP cord-297469-26d8o1xk 142 25 was be VBD cord-297469-26d8o1xk 142 26 shown show VBN cord-297469-26d8o1xk 142 27 that that IN cord-297469-26d8o1xk 142 28 UA UA NNP cord-297469-26d8o1xk 142 29 suppressed suppress VBD cord-297469-26d8o1xk 142 30 the the DT cord-297469-26d8o1xk 142 31 expression expression NN cord-297469-26d8o1xk 142 32 of of IN cord-297469-26d8o1xk 142 33 TGF TGF NNP cord-297469-26d8o1xk 142 34 - - HYPH cord-297469-26d8o1xk 142 35 β1 β1 NNP cord-297469-26d8o1xk 142 36 in in IN cord-297469-26d8o1xk 142 37 immune immune JJ cord-297469-26d8o1xk 142 38 cells cell NNS cord-297469-26d8o1xk 142 39 by by IN cord-297469-26d8o1xk 142 40 inhibiting inhibit VBG cord-297469-26d8o1xk 142 41 the the DT cord-297469-26d8o1xk 142 42 survival survival NN cord-297469-26d8o1xk 142 43 of of IN cord-297469-26d8o1xk 142 44 T. t. NN cord-297469-26d8o1xk 142 45 gondii gondii NNP cord-297469-26d8o1xk 142 46 . . . cord-297469-26d8o1xk 143 1 In in IN cord-297469-26d8o1xk 143 2 addition addition NN cord-297469-26d8o1xk 143 3 , , , cord-297469-26d8o1xk 143 4 UA UA NNP cord-297469-26d8o1xk 143 5 not not RB cord-297469-26d8o1xk 143 6 only only RB cord-297469-26d8o1xk 143 7 effectively effectively RB cord-297469-26d8o1xk 143 8 increased increase VBD cord-297469-26d8o1xk 143 9 the the DT cord-297469-26d8o1xk 143 10 production production NN cord-297469-26d8o1xk 143 11 of of IN cord-297469-26d8o1xk 143 12 anti anti JJ cord-297469-26d8o1xk 143 13 - - JJ cord-297469-26d8o1xk 143 14 inflammatory inflammatory JJ cord-297469-26d8o1xk 143 15 cytokines cytokine NNS cord-297469-26d8o1xk 143 16 such such JJ cord-297469-26d8o1xk 143 17 as as IN cord-297469-26d8o1xk 143 18 IL-10 IL-10 NNP cord-297469-26d8o1xk 143 19 and and CC cord-297469-26d8o1xk 143 20 interferon interferon NN cord-297469-26d8o1xk 143 21 - - HYPH cord-297469-26d8o1xk 143 22 β β NN cord-297469-26d8o1xk 143 23 in in IN cord-297469-26d8o1xk 143 24 T. T. NNP cord-297469-26d8o1xk 143 25 gondii gondii NN cord-297469-26d8o1xk 143 26 - - HYPH cord-297469-26d8o1xk 143 27 infected infect VBN cord-297469-26d8o1xk 143 28 cells cell NNS cord-297469-26d8o1xk 143 29 but but CC cord-297469-26d8o1xk 143 30 also also RB cord-297469-26d8o1xk 143 31 activated activate VBD cord-297469-26d8o1xk 143 32 the the DT cord-297469-26d8o1xk 143 33 expression expression NN cord-297469-26d8o1xk 143 34 of of IN cord-297469-26d8o1xk 143 35 IL-12 IL-12 NNP cord-297469-26d8o1xk 143 36 and and CC cord-297469-26d8o1xk 143 37 GM GM NNP cord-297469-26d8o1xk 143 38 - - HYPH cord-297469-26d8o1xk 143 39 CSF CSF NNP cord-297469-26d8o1xk 143 40 , , , cord-297469-26d8o1xk 143 41 promoting promote VBG cord-297469-26d8o1xk 143 42 the the DT cord-297469-26d8o1xk 143 43 development development NN cord-297469-26d8o1xk 143 44 of of IN cord-297469-26d8o1xk 143 45 Th1 th1 NN cord-297469-26d8o1xk 143 46 cells cell NNS cord-297469-26d8o1xk 143 47 and and CC cord-297469-26d8o1xk 143 48 the the DT cord-297469-26d8o1xk 143 49 production production NN cord-297469-26d8o1xk 143 50 of of IN cord-297469-26d8o1xk 143 51 interferon interferon NN cord-297469-26d8o1xk 143 52 - - HYPH cord-297469-26d8o1xk 143 53 γ γ NN cord-297469-26d8o1xk 143 54 that that WDT cord-297469-26d8o1xk 143 55 is be VBZ cord-297469-26d8o1xk 143 56 induced induce VBN cord-297469-26d8o1xk 143 57 by by IN cord-297469-26d8o1xk 143 58 NK NK NNP cord-297469-26d8o1xk 143 59 cells cell NNS cord-297469-26d8o1xk 143 60 . . . cord-297469-26d8o1xk 144 1 Taken take VBN cord-297469-26d8o1xk 144 2 together together RB cord-297469-26d8o1xk 144 3 , , , cord-297469-26d8o1xk 144 4 the the DT cord-297469-26d8o1xk 144 5 results result NNS cord-297469-26d8o1xk 144 6 of of IN cord-297469-26d8o1xk 144 7 this this DT cord-297469-26d8o1xk 144 8 study study NN cord-297469-26d8o1xk 144 9 showed show VBD cord-297469-26d8o1xk 144 10 the the DT cord-297469-26d8o1xk 144 11 anti anti JJ cord-297469-26d8o1xk 144 12 - - JJ cord-297469-26d8o1xk 144 13 parasitic parasitic JJ cord-297469-26d8o1xk 144 14 effects effect NNS cord-297469-26d8o1xk 144 15 of of IN cord-297469-26d8o1xk 144 16 UA UA NNP cord-297469-26d8o1xk 144 17 against against IN cord-297469-26d8o1xk 144 18 the the DT cord-297469-26d8o1xk 144 19 survival survival NN cord-297469-26d8o1xk 144 20 of of IN cord-297469-26d8o1xk 144 21 T. t. NN cord-297469-26d8o1xk 144 22 gondii gondii NNP cord-297469-26d8o1xk 144 23 as as RB cord-297469-26d8o1xk 144 24 well well RB cord-297469-26d8o1xk 144 25 as as IN cord-297469-26d8o1xk 144 26 demonstrated demonstrate VBN cord-297469-26d8o1xk 144 27 its -PRON- PRP$ cord-297469-26d8o1xk 144 28 mechanism mechanism NN cord-297469-26d8o1xk 144 29 of of IN cord-297469-26d8o1xk 144 30 action action NN cord-297469-26d8o1xk 144 31 causing cause VBG cord-297469-26d8o1xk 144 32 anti anti JJ cord-297469-26d8o1xk 144 33 - - JJ cord-297469-26d8o1xk 144 34 T. t. JJ cord-297469-26d8o1xk 144 35 gondii gondii NN cord-297469-26d8o1xk 144 36 effect effect NN cord-297469-26d8o1xk 144 37 in in IN cord-297469-26d8o1xk 144 38 T. T. NNP cord-297469-26d8o1xk 144 39 gondii gondii NNP cord-297469-26d8o1xk 144 40 - - HYPH cord-297469-26d8o1xk 144 41 infected infect VBN cord-297469-26d8o1xk 144 42 co co JJ cord-297469-26d8o1xk 144 43 - - JJ cord-297469-26d8o1xk 144 44 cultured cultured JJ cord-297469-26d8o1xk 144 45 cells cell NNS cord-297469-26d8o1xk 144 46 . . . cord-297469-26d8o1xk 145 1 Furthermore furthermore RB cord-297469-26d8o1xk 145 2 , , , cord-297469-26d8o1xk 145 3 these these DT cord-297469-26d8o1xk 145 4 results result NNS cord-297469-26d8o1xk 145 5 indicated indicate VBD cord-297469-26d8o1xk 145 6 that that IN cord-297469-26d8o1xk 145 7 the the DT cord-297469-26d8o1xk 145 8 expression expression NN cord-297469-26d8o1xk 145 9 of of IN cord-297469-26d8o1xk 145 10 subcellular subcellular JJ cord-297469-26d8o1xk 145 11 organelles organelle NNS cord-297469-26d8o1xk 145 12 and and CC cord-297469-26d8o1xk 145 13 granules granule NNS cord-297469-26d8o1xk 145 14 of of IN cord-297469-26d8o1xk 145 15 T. t. NN cord-297469-26d8o1xk 145 16 gondii gondii NNP cord-297469-26d8o1xk 145 17 was be VBD cord-297469-26d8o1xk 145 18 specifically specifically RB cord-297469-26d8o1xk 145 19 inhibited inhibit VBN cord-297469-26d8o1xk 145 20 or or CC cord-297469-26d8o1xk 145 21 blocked block VBN cord-297469-26d8o1xk 145 22 in in IN cord-297469-26d8o1xk 145 23 a a DT cord-297469-26d8o1xk 145 24 concentration concentration NN cord-297469-26d8o1xk 145 25 - - HYPH cord-297469-26d8o1xk 145 26 dependent dependent JJ cord-297469-26d8o1xk 145 27 manner manner NN cord-297469-26d8o1xk 145 28 after after IN cord-297469-26d8o1xk 145 29 treatment treatment NN cord-297469-26d8o1xk 145 30 with with IN cord-297469-26d8o1xk 145 31 UA UA NNP cord-297469-26d8o1xk 145 32 . . . cord-297469-26d8o1xk 146 1 This this DT cord-297469-26d8o1xk 146 2 study study NN cord-297469-26d8o1xk 146 3 provides provide VBZ cord-297469-26d8o1xk 146 4 evidence evidence NN cord-297469-26d8o1xk 146 5 that that IN cord-297469-26d8o1xk 146 6 UA UA NNP cord-297469-26d8o1xk 146 7 not not RB cord-297469-26d8o1xk 146 8 only only RB cord-297469-26d8o1xk 146 9 decreases decrease VBZ cord-297469-26d8o1xk 146 10 the the DT cord-297469-26d8o1xk 146 11 inflammatory inflammatory JJ cord-297469-26d8o1xk 146 12 cytokines cytokine NNS cord-297469-26d8o1xk 146 13 ( ( -LRB- cord-297469-26d8o1xk 146 14 IL-1β IL-1β NNP cord-297469-26d8o1xk 146 15 , , , cord-297469-26d8o1xk 146 16 IL-6 IL-6 NNP cord-297469-26d8o1xk 146 17 and and CC cord-297469-26d8o1xk 146 18 TNF TNF NNP cord-297469-26d8o1xk 146 19 - - HYPH cord-297469-26d8o1xk 146 20 α α NNP cord-297469-26d8o1xk 146 21 ) ) -RRB- cord-297469-26d8o1xk 146 22 expressed express VBD cord-297469-26d8o1xk 146 23 from from IN cord-297469-26d8o1xk 146 24 the the DT cord-297469-26d8o1xk 146 25 immune immune JJ cord-297469-26d8o1xk 146 26 cells cell NNS cord-297469-26d8o1xk 146 27 after after IN cord-297469-26d8o1xk 146 28 T. t. NN cord-297469-26d8o1xk 146 29 gondii gondii NN cord-297469-26d8o1xk 146 30 infection infection NN cord-297469-26d8o1xk 146 31 , , , cord-297469-26d8o1xk 146 32 but but CC cord-297469-26d8o1xk 146 33 also also RB cord-297469-26d8o1xk 146 34 effectively effectively RB cord-297469-26d8o1xk 146 35 increases increase VBZ cord-297469-26d8o1xk 146 36 the the DT cord-297469-26d8o1xk 146 37 production production NN cord-297469-26d8o1xk 146 38 of of IN cord-297469-26d8o1xk 146 39 anti anti JJ cord-297469-26d8o1xk 146 40 - - JJ cord-297469-26d8o1xk 146 41 inflammatory inflammatory JJ cord-297469-26d8o1xk 146 42 mediators mediator NNS cord-297469-26d8o1xk 146 43 such such JJ cord-297469-26d8o1xk 146 44 as as IN cord-297469-26d8o1xk 146 45 IL-10 IL-10 NNP cord-297469-26d8o1xk 146 46 , , , cord-297469-26d8o1xk 146 47 IL-12 IL-12 NNP cord-297469-26d8o1xk 146 48 , , , cord-297469-26d8o1xk 146 49 GM GM NNP cord-297469-26d8o1xk 146 50 - - HYPH cord-297469-26d8o1xk 146 51 CSF CSF NNP cord-297469-26d8o1xk 146 52 , , , cord-297469-26d8o1xk 146 53 and and CC cord-297469-26d8o1xk 146 54 interferon interferon NN cord-297469-26d8o1xk 146 55 - - HYPH cord-297469-26d8o1xk 146 56 β β XX cord-297469-26d8o1xk 146 57 , , , cord-297469-26d8o1xk 146 58 including include VBG cord-297469-26d8o1xk 146 59 the the DT cord-297469-26d8o1xk 146 60 activation activation NN cord-297469-26d8o1xk 146 61 of of IN cord-297469-26d8o1xk 146 62 ROS ROS NNP cord-297469-26d8o1xk 146 63 and and CC cord-297469-26d8o1xk 146 64 NO no DT cord-297469-26d8o1xk 146 65 production production NN cord-297469-26d8o1xk 146 66 . . . cord-297469-26d8o1xk 147 1 Interestingly interestingly RB cord-297469-26d8o1xk 147 2 , , , cord-297469-26d8o1xk 147 3 it -PRON- PRP cord-297469-26d8o1xk 147 4 was be VBD cord-297469-26d8o1xk 147 5 confirmed confirm VBN cord-297469-26d8o1xk 147 6 in in IN cord-297469-26d8o1xk 147 7 this this DT cord-297469-26d8o1xk 147 8 study study NN cord-297469-26d8o1xk 147 9 that that DT cord-297469-26d8o1xk 147 10 macrophage macrophage NN cord-297469-26d8o1xk 147 11 and and CC cord-297469-26d8o1xk 147 12 other other JJ cord-297469-26d8o1xk 147 13 immune immune JJ cord-297469-26d8o1xk 147 14 cells cell NNS cord-297469-26d8o1xk 147 15 did do VBD cord-297469-26d8o1xk 147 16 not not RB cord-297469-26d8o1xk 147 17 directly directly RB cord-297469-26d8o1xk 147 18 inhibit inhibit VB cord-297469-26d8o1xk 147 19 or or CC cord-297469-26d8o1xk 147 20 rapidly rapidly RB cord-297469-26d8o1xk 147 21 decrease decrease VB cord-297469-26d8o1xk 147 22 the the DT cord-297469-26d8o1xk 147 23 survival survival NN cord-297469-26d8o1xk 147 24 of of IN cord-297469-26d8o1xk 147 25 parasite parasite NN cord-297469-26d8o1xk 147 26 as as RB cord-297469-26d8o1xk 147 27 well well RB cord-297469-26d8o1xk 147 28 as as IN cord-297469-26d8o1xk 147 29 the the DT cord-297469-26d8o1xk 147 30 proliferation proliferation NN cord-297469-26d8o1xk 147 31 of of IN cord-297469-26d8o1xk 147 32 T. t. NN cord-297469-26d8o1xk 147 33 gondii gondii NN cord-297469-26d8o1xk 147 34 through through IN cord-297469-26d8o1xk 147 35 the the DT cord-297469-26d8o1xk 147 36 bactericidal bactericidal JJ cord-297469-26d8o1xk 147 37 action action NN cord-297469-26d8o1xk 147 38 such such JJ cord-297469-26d8o1xk 147 39 as as IN cord-297469-26d8o1xk 147 40 phagocytosis phagocytosis NN cord-297469-26d8o1xk 147 41 of of IN cord-297469-26d8o1xk 147 42 macrophage macrophage NN cord-297469-26d8o1xk 147 43 after after IN cord-297469-26d8o1xk 147 44 T. T. NNP cord-297469-26d8o1xk 147 45 gondii gondii NNP cord-297469-26d8o1xk 147 46 infection infection NN cord-297469-26d8o1xk 147 47 . . . cord-297469-26d8o1xk 148 1 This this DT cord-297469-26d8o1xk 148 2 may may MD cord-297469-26d8o1xk 148 3 be be VB cord-297469-26d8o1xk 148 4 the the DT cord-297469-26d8o1xk 148 5 result result NN cord-297469-26d8o1xk 148 6 of of IN cord-297469-26d8o1xk 148 7 the the DT cord-297469-26d8o1xk 148 8 differences difference NNS cord-297469-26d8o1xk 148 9 between between IN cord-297469-26d8o1xk 148 10 the the DT cord-297469-26d8o1xk 148 11 in in FW cord-297469-26d8o1xk 148 12 vitro vitro FW cord-297469-26d8o1xk 148 13 system system NN cord-297469-26d8o1xk 148 14 and and CC cord-297469-26d8o1xk 148 15 the the DT cord-297469-26d8o1xk 148 16 in in IN cord-297469-26d8o1xk 148 17 vivo vivo NN cord-297469-26d8o1xk 148 18 experiment experiment NN cord-297469-26d8o1xk 148 19 including include VBG cord-297469-26d8o1xk 148 20 rats rat NNS cord-297469-26d8o1xk 148 21 and and CC cord-297469-26d8o1xk 148 22 mice mouse NNS cord-297469-26d8o1xk 148 23 . . . cord-297469-26d8o1xk 149 1 However however RB cord-297469-26d8o1xk 149 2 , , , cord-297469-26d8o1xk 149 3 the the DT cord-297469-26d8o1xk 149 4 parasite parasite NN cord-297469-26d8o1xk 149 5 may may MD cord-297469-26d8o1xk 149 6 not not RB cord-297469-26d8o1xk 149 7 be be VB cord-297469-26d8o1xk 149 8 eliminated eliminate VBN cord-297469-26d8o1xk 149 9 by by IN cord-297469-26d8o1xk 149 10 the the DT cord-297469-26d8o1xk 149 11 bactericidal bactericidal JJ cord-297469-26d8o1xk 149 12 action action NN cord-297469-26d8o1xk 149 13 of of IN cord-297469-26d8o1xk 149 14 macrophages macrophage NNS cord-297469-26d8o1xk 149 15 and and CC cord-297469-26d8o1xk 149 16 other other JJ cord-297469-26d8o1xk 149 17 immune immune JJ cord-297469-26d8o1xk 149 18 cells cell NNS cord-297469-26d8o1xk 149 19 in in IN cord-297469-26d8o1xk 149 20 the the DT cord-297469-26d8o1xk 149 21 infected infected JJ cord-297469-26d8o1xk 149 22 body body NN cord-297469-26d8o1xk 149 23 because because IN cord-297469-26d8o1xk 149 24 T. T. NNP cord-297469-26d8o1xk 149 25 gondii gondii NNP cord-297469-26d8o1xk 149 26 is be VBZ cord-297469-26d8o1xk 149 27 found find VBN cord-297469-26d8o1xk 149 28 in in IN cord-297469-26d8o1xk 149 29 various various JJ cord-297469-26d8o1xk 149 30 body body NN cord-297469-26d8o1xk 149 31 sites site NNS cord-297469-26d8o1xk 149 32 of of IN cord-297469-26d8o1xk 149 33 patients patient NNS cord-297469-26d8o1xk 149 34 in in IN cord-297469-26d8o1xk 149 35 the the DT cord-297469-26d8o1xk 149 36 clinic clinic NN cord-297469-26d8o1xk 149 37 . . . cord-297469-26d8o1xk 150 1 Moreover moreover RB cord-297469-26d8o1xk 150 2 , , , cord-297469-26d8o1xk 150 3 it -PRON- PRP cord-297469-26d8o1xk 150 4 may may MD cord-297469-26d8o1xk 150 5 be be VB cord-297469-26d8o1xk 150 6 changed change VBN cord-297469-26d8o1xk 150 7 or or CC cord-297469-26d8o1xk 150 8 maintained maintain VBN cord-297469-26d8o1xk 150 9 to to IN cord-297469-26d8o1xk 150 10 the the DT cord-297469-26d8o1xk 150 11 parasite parasite NN cord-297469-26d8o1xk 150 12 type type NN cord-297469-26d8o1xk 150 13 that that WDT cord-297469-26d8o1xk 150 14 indicates indicate VBZ cord-297469-26d8o1xk 150 15 characteristics characteristic NNS cord-297469-26d8o1xk 150 16 of of IN cord-297469-26d8o1xk 150 17 hibernation hibernation NN cord-297469-26d8o1xk 150 18 like like IN cord-297469-26d8o1xk 150 19 T. t. NN cord-297469-26d8o1xk 150 20 gondii gondii NNP cord-297469-26d8o1xk 150 21 ME49 ME49 NNP cord-297469-26d8o1xk 150 22 strain strain NN cord-297469-26d8o1xk 150 23 ( ( -LRB- cord-297469-26d8o1xk 150 24 type type NN cord-297469-26d8o1xk 150 25 II II NNP cord-297469-26d8o1xk 150 26 ) ) -RRB- cord-297469-26d8o1xk 150 27 in in IN cord-297469-26d8o1xk 150 28 the the DT cord-297469-26d8o1xk 150 29 body body NN cord-297469-26d8o1xk 150 30 . . . cord-297469-26d8o1xk 151 1 In in IN cord-297469-26d8o1xk 151 2 summary summary NN cord-297469-26d8o1xk 151 3 , , , cord-297469-26d8o1xk 151 4 the the DT cord-297469-26d8o1xk 151 5 results result NNS cord-297469-26d8o1xk 151 6 of of IN cord-297469-26d8o1xk 151 7 this this DT cord-297469-26d8o1xk 151 8 study study NN cord-297469-26d8o1xk 151 9 demonstrate demonstrate VBP cord-297469-26d8o1xk 151 10 that that IN cord-297469-26d8o1xk 151 11 UA UA NNP cord-297469-26d8o1xk 151 12 induces induce VBZ cord-297469-26d8o1xk 151 13 anti anti JJ cord-297469-26d8o1xk 151 14 - - JJ cord-297469-26d8o1xk 151 15 T. t. JJ cord-297469-26d8o1xk 151 16 gondii gondii NN cord-297469-26d8o1xk 151 17 effects effect NNS cord-297469-26d8o1xk 151 18 / / SYM cord-297469-26d8o1xk 151 19 action action NN cord-297469-26d8o1xk 151 20 by by IN cord-297469-26d8o1xk 151 21 effectively effectively RB cord-297469-26d8o1xk 151 22 blocking block VBG cord-297469-26d8o1xk 151 23 or or CC cord-297469-26d8o1xk 151 24 inhibiting inhibit VBG cord-297469-26d8o1xk 151 25 the the DT cord-297469-26d8o1xk 151 26 survival survival NN cord-297469-26d8o1xk 151 27 of of IN cord-297469-26d8o1xk 151 28 T. t. NN cord-297469-26d8o1xk 151 29 gondii gondii NN cord-297469-26d8o1xk 151 30 , , , cord-297469-26d8o1xk 151 31 and and CC cord-297469-26d8o1xk 151 32 also also RB cord-297469-26d8o1xk 151 33 has have VBZ cord-297469-26d8o1xk 151 34 anti anti JJ cord-297469-26d8o1xk 151 35 - - JJ cord-297469-26d8o1xk 151 36 parasitic parasitic JJ cord-297469-26d8o1xk 151 37 activity activity NN cord-297469-26d8o1xk 151 38 that that WDT cord-297469-26d8o1xk 151 39 consistently consistently RB cord-297469-26d8o1xk 151 40 inhibits inhibit VBZ cord-297469-26d8o1xk 151 41 the the DT cord-297469-26d8o1xk 151 42 proliferation proliferation NN cord-297469-26d8o1xk 151 43 / / SYM cord-297469-26d8o1xk 151 44 growth growth NN cord-297469-26d8o1xk 151 45 of of IN cord-297469-26d8o1xk 151 46 T. t. NN cord-297469-26d8o1xk 151 47 gondii gondii NN cord-297469-26d8o1xk 151 48 by by IN cord-297469-26d8o1xk 151 49 strongly strongly RB cord-297469-26d8o1xk 151 50 inhibiting inhibit VBG cord-297469-26d8o1xk 151 51 the the DT cord-297469-26d8o1xk 151 52 expression expression NN cord-297469-26d8o1xk 151 53 of of IN cord-297469-26d8o1xk 151 54 subcellular subcellular JJ cord-297469-26d8o1xk 151 55 organelles organelle NNS cord-297469-26d8o1xk 151 56 and and CC cord-297469-26d8o1xk 151 57 granules granule NNS cord-297469-26d8o1xk 151 58 of of IN cord-297469-26d8o1xk 151 59 T. t. NN cord-297469-26d8o1xk 151 60 gondii gondii NN cord-297469-26d8o1xk 151 61 , , , cord-297469-26d8o1xk 151 62 such such JJ cord-297469-26d8o1xk 151 63 as as IN cord-297469-26d8o1xk 151 64 ROP ROP NNP cord-297469-26d8o1xk 151 65 18 18 CD cord-297469-26d8o1xk 151 66 , , , cord-297469-26d8o1xk 151 67 MIC MIC NNP cord-297469-26d8o1xk 151 68 8 8 CD cord-297469-26d8o1xk 151 69 , , , cord-297469-26d8o1xk 151 70 and and CC cord-297469-26d8o1xk 151 71 IMC IMC NNP cord-297469-26d8o1xk 151 72 sub sub NNP cord-297469-26d8o1xk 151 73 3 3 CD cord-297469-26d8o1xk 151 74 in in IN cord-297469-26d8o1xk 151 75 T. T. NNP cord-297469-26d8o1xk 151 76 gondii gondii NN cord-297469-26d8o1xk 151 77 - - HYPH cord-297469-26d8o1xk 151 78 infected infect VBN cord-297469-26d8o1xk 151 79 cells cell NNS cord-297469-26d8o1xk 151 80 . . . cord-297469-26d8o1xk 152 1 In in IN cord-297469-26d8o1xk 152 2 addition addition NN cord-297469-26d8o1xk 152 3 , , , cord-297469-26d8o1xk 152 4 these these DT cord-297469-26d8o1xk 152 5 results result NNS cord-297469-26d8o1xk 152 6 show show VBP cord-297469-26d8o1xk 152 7 clearly clearly RB cord-297469-26d8o1xk 152 8 that that IN cord-297469-26d8o1xk 152 9 UA UA NNP cord-297469-26d8o1xk 152 10 has have VBZ cord-297469-26d8o1xk 152 11 the the DT cord-297469-26d8o1xk 152 12 immunomodulatory immunomodulatory JJ cord-297469-26d8o1xk 152 13 action action NN cord-297469-26d8o1xk 152 14 / / SYM cord-297469-26d8o1xk 152 15 activity activity NN cord-297469-26d8o1xk 152 16 which which WDT cord-297469-26d8o1xk 152 17 causes cause VBZ cord-297469-26d8o1xk 152 18 the the DT cord-297469-26d8o1xk 152 19 change change NN cord-297469-26d8o1xk 152 20 of of IN cord-297469-26d8o1xk 152 21 cytokines cytokine NNS cord-297469-26d8o1xk 152 22 in in IN cord-297469-26d8o1xk 152 23 immune immune JJ cord-297469-26d8o1xk 152 24 cells cell NNS cord-297469-26d8o1xk 152 25 by by IN cord-297469-26d8o1xk 152 26 decreasing decrease VBG cord-297469-26d8o1xk 152 27 the the DT cord-297469-26d8o1xk 152 28 inflammatory inflammatory JJ cord-297469-26d8o1xk 152 29 cytokines cytokine NNS cord-297469-26d8o1xk 152 30 ( ( -LRB- cord-297469-26d8o1xk 152 31 IL-1β IL-1β NNP cord-297469-26d8o1xk 152 32 , , , cord-297469-26d8o1xk 152 33 IL-6 IL-6 NNP cord-297469-26d8o1xk 152 34 , , , cord-297469-26d8o1xk 152 35 and and CC cord-297469-26d8o1xk 152 36 TNF TNF NNP cord-297469-26d8o1xk 152 37 - - HYPH cord-297469-26d8o1xk 152 38 α α NNP cord-297469-26d8o1xk 152 39 ) ) -RRB- cord-297469-26d8o1xk 152 40 and/or and/or CC cord-297469-26d8o1xk 152 41 by by IN cord-297469-26d8o1xk 152 42 activating activate VBG cord-297469-26d8o1xk 152 43 anti anti JJ cord-297469-26d8o1xk 152 44 - - JJ cord-297469-26d8o1xk 152 45 inflammatory inflammatory JJ cord-297469-26d8o1xk 152 46 cytokines cytokine NNS cord-297469-26d8o1xk 152 47 including include VBG cord-297469-26d8o1xk 152 48 IL-10 IL-10 NNP cord-297469-26d8o1xk 152 49 , , , cord-297469-26d8o1xk 152 50 IL-12 IL-12 NNP cord-297469-26d8o1xk 152 51 , , , cord-297469-26d8o1xk 152 52 GM GM NNP cord-297469-26d8o1xk 152 53 - - HYPH cord-297469-26d8o1xk 152 54 CSF CSF NNP cord-297469-26d8o1xk 152 55 , , , cord-297469-26d8o1xk 152 56 or or CC cord-297469-26d8o1xk 152 57 interferon interferon NN cord-297469-26d8o1xk 152 58 - - : cord-297469-26d8o1xk 152 59 β β NN cord-297469-26d8o1xk 152 60 through through IN cord-297469-26d8o1xk 152 61 the the DT cord-297469-26d8o1xk 152 62 interaction interaction NN cord-297469-26d8o1xk 152 63 between between IN cord-297469-26d8o1xk 152 64 UA UA NNP cord-297469-26d8o1xk 152 65 and and CC cord-297469-26d8o1xk 152 66 immune immune JJ cord-297469-26d8o1xk 152 67 cells cell NNS cord-297469-26d8o1xk 152 68 . . . cord-297469-26d8o1xk 153 1 Furthermore furthermore RB cord-297469-26d8o1xk 153 2 , , , cord-297469-26d8o1xk 153 3 the the DT cord-297469-26d8o1xk 153 4 results result NNS cord-297469-26d8o1xk 153 5 indicate indicate VBP cord-297469-26d8o1xk 153 6 that that IN cord-297469-26d8o1xk 153 7 UA UA NNP cord-297469-26d8o1xk 153 8 induces induce VBZ cord-297469-26d8o1xk 153 9 the the DT cord-297469-26d8o1xk 153 10 death death NN cord-297469-26d8o1xk 153 11 of of IN cord-297469-26d8o1xk 153 12 T. t. NN cord-297469-26d8o1xk 153 13 gondii gondii NNP cord-297469-26d8o1xk 153 14 by by IN cord-297469-26d8o1xk 153 15 promoting promote VBG cord-297469-26d8o1xk 153 16 the the DT cord-297469-26d8o1xk 153 17 production production NN cord-297469-26d8o1xk 153 18 of of IN cord-297469-26d8o1xk 153 19 ROS ROS NNP cord-297469-26d8o1xk 153 20 and and CC cord-297469-26d8o1xk 153 21 NO no UH cord-297469-26d8o1xk 153 22 , , , cord-297469-26d8o1xk 153 23 such such JJ cord-297469-26d8o1xk 153 24 as as IN cord-297469-26d8o1xk 153 25 super super JJ cord-297469-26d8o1xk 153 26 oxides oxide NNS cord-297469-26d8o1xk 153 27 and and CC cord-297469-26d8o1xk 153 28 hydroxyl hydroxyl NN cord-297469-26d8o1xk 153 29 radicals radical NNS cord-297469-26d8o1xk 153 30 in in IN cord-297469-26d8o1xk 153 31 T. T. NNP cord-297469-26d8o1xk 153 32 gondii gondii NN cord-297469-26d8o1xk 153 33 - - HYPH cord-297469-26d8o1xk 153 34 infected infect VBN cord-297469-26d8o1xk 153 35 immune immune JJ cord-297469-26d8o1xk 153 36 cells cell NNS cord-297469-26d8o1xk 153 37 . . . cord-297469-26d8o1xk 154 1 Therefore therefore RB cord-297469-26d8o1xk 154 2 , , , cord-297469-26d8o1xk 154 3 this this DT cord-297469-26d8o1xk 154 4 study study NN cord-297469-26d8o1xk 154 5 indicates indicate VBZ cord-297469-26d8o1xk 154 6 that that IN cord-297469-26d8o1xk 154 7 UA UA NNP cord-297469-26d8o1xk 154 8 can can MD cord-297469-26d8o1xk 154 9 be be VB cord-297469-26d8o1xk 154 10 used use VBN cord-297469-26d8o1xk 154 11 effectively effectively RB cord-297469-26d8o1xk 154 12 as as IN cord-297469-26d8o1xk 154 13 a a DT cord-297469-26d8o1xk 154 14 potent potent JJ cord-297469-26d8o1xk 154 15 candidate candidate NN cord-297469-26d8o1xk 154 16 agent agent NN cord-297469-26d8o1xk 154 17 or or CC cord-297469-26d8o1xk 154 18 a a DT cord-297469-26d8o1xk 154 19 synergic synergic JJ cord-297469-26d8o1xk 154 20 compound compound NN cord-297469-26d8o1xk 154 21 with with IN cord-297469-26d8o1xk 154 22 existing exist VBG cord-297469-26d8o1xk 154 23 drugs drug NNS cord-297469-26d8o1xk 154 24 in in IN cord-297469-26d8o1xk 154 25 the the DT cord-297469-26d8o1xk 154 26 development development NN cord-297469-26d8o1xk 154 27 of of IN cord-297469-26d8o1xk 154 28 novel novel JJ cord-297469-26d8o1xk 154 29 anti anti JJ cord-297469-26d8o1xk 154 30 - - JJ cord-297469-26d8o1xk 154 31 T. t. JJ cord-297469-26d8o1xk 154 32 gondii gondii NN cord-297469-26d8o1xk 154 33 drugs drug NNS cord-297469-26d8o1xk 154 34 of of IN cord-297469-26d8o1xk 154 35 the the DT cord-297469-26d8o1xk 154 36 next next JJ cord-297469-26d8o1xk 154 37 generation generation NN cord-297469-26d8o1xk 154 38 against against IN cord-297469-26d8o1xk 154 39 toxoplasmosis toxoplasmosis NN cord-297469-26d8o1xk 154 40 , , , cord-297469-26d8o1xk 154 41 with with IN cord-297469-26d8o1xk 154 42 potential potential NN cord-297469-26d8o1xk 154 43 as as IN cord-297469-26d8o1xk 154 44 a a DT cord-297469-26d8o1xk 154 45 modulatory modulatory JJ cord-297469-26d8o1xk 154 46 substance substance NN cord-297469-26d8o1xk 154 47 against against IN cord-297469-26d8o1xk 154 48 the the DT cord-297469-26d8o1xk 154 49 immune immune JJ cord-297469-26d8o1xk 154 50 response response NN cord-297469-26d8o1xk 154 51 of of IN cord-297469-26d8o1xk 154 52 the the DT cord-297469-26d8o1xk 154 53 parasite parasite NN cord-297469-26d8o1xk 154 54 in in IN cord-297469-26d8o1xk 154 55 parasite parasite NN cord-297469-26d8o1xk 154 56 - - HYPH cord-297469-26d8o1xk 154 57 infected infect VBN cord-297469-26d8o1xk 154 58 immune immune JJ cord-297469-26d8o1xk 154 59 cells cell NNS cord-297469-26d8o1xk 154 60 . . . cord-297469-26d8o1xk 155 1 Moreover moreover RB cord-297469-26d8o1xk 155 2 , , , cord-297469-26d8o1xk 155 3 UA UA NNP cord-297469-26d8o1xk 155 4 requires require VBZ cord-297469-26d8o1xk 155 5 further further JJ cord-297469-26d8o1xk 155 6 study study NN cord-297469-26d8o1xk 155 7 for for IN cord-297469-26d8o1xk 155 8 efficacy efficacy NN cord-297469-26d8o1xk 155 9 and and CC cord-297469-26d8o1xk 155 10 safety safety NN cord-297469-26d8o1xk 155 11 against against IN cord-297469-26d8o1xk 155 12 toxoplasmosis toxoplasmosis NN cord-297469-26d8o1xk 155 13 in in IN cord-297469-26d8o1xk 155 14 preclinical preclinical JJ cord-297469-26d8o1xk 155 15 stages stage NNS cord-297469-26d8o1xk 155 16 through through IN cord-297469-26d8o1xk 155 17 in in IN cord-297469-26d8o1xk 155 18 vivo vivo NN cord-297469-26d8o1xk 155 19 animal animal NN cord-297469-26d8o1xk 155 20 models model NNS cord-297469-26d8o1xk 155 21 in in IN cord-297469-26d8o1xk 155 22 the the DT cord-297469-26d8o1xk 155 23 near near JJ cord-297469-26d8o1xk 155 24 future future NN cord-297469-26d8o1xk 155 25 . . . cord-297469-26d8o1xk 155 26 _SP cord-297469-26d8o1xk 156 1 The the DT cord-297469-26d8o1xk 156 2 anti anti JJ cord-297469-26d8o1xk 156 3 - - JJ cord-297469-26d8o1xk 156 4 toxoplasmosis toxoplasmosis JJ cord-297469-26d8o1xk 156 5 drug drug NN cord-297469-26d8o1xk 156 6 , , , cord-297469-26d8o1xk 156 7 sulfadiazine sulfadiazine NNP cord-297469-26d8o1xk 156 8 ( ( -LRB- cord-297469-26d8o1xk 156 9 SF SF NNP cord-297469-26d8o1xk 156 10 ) ) -RRB- cord-297469-26d8o1xk 156 11 , , , cord-297469-26d8o1xk 156 12 was be VBD cord-297469-26d8o1xk 156 13 dissolved dissolve VBN cord-297469-26d8o1xk 156 14 in in IN cord-297469-26d8o1xk 156 15 DMSO DMSO NNP cord-297469-26d8o1xk 156 16 , , , cord-297469-26d8o1xk 156 17 and and CC cord-297469-26d8o1xk 156 18 ursolic ursolic JJ cord-297469-26d8o1xk 156 19 acid acid NNP cord-297469-26d8o1xk 156 20 ( ( -LRB- cord-297469-26d8o1xk 156 21 UA UA NNP cord-297469-26d8o1xk 156 22 ) ) -RRB- cord-297469-26d8o1xk 156 23 was be VBD cord-297469-26d8o1xk 156 24 also also RB cord-297469-26d8o1xk 156 25 dissolved dissolve VBN cord-297469-26d8o1xk 156 26 in in IN cord-297469-26d8o1xk 156 27 DMSO DMSO NNP cord-297469-26d8o1xk 156 28 to to IN cord-297469-26d8o1xk 156 29 a a DT cord-297469-26d8o1xk 156 30 concentration concentration NN cord-297469-26d8o1xk 156 31 of of IN cord-297469-26d8o1xk 156 32 50 50 CD cord-297469-26d8o1xk 156 33 mg mg NNP cord-297469-26d8o1xk 156 34 / / SYM cord-297469-26d8o1xk 156 35 mL ml NN cord-297469-26d8o1xk 156 36 according accord VBG cord-297469-26d8o1xk 156 37 to to IN cord-297469-26d8o1xk 156 38 the the DT cord-297469-26d8o1xk 156 39 manufacturer manufacturer NN cord-297469-26d8o1xk 156 40 's 's POS cord-297469-26d8o1xk 156 41 instructions instruction NNS cord-297469-26d8o1xk 156 42 . . . cord-297469-26d8o1xk 157 1 Sulfadiazine Sulfadiazine NNP cord-297469-26d8o1xk 157 2 was be VBD cord-297469-26d8o1xk 157 3 used use VBN cord-297469-26d8o1xk 157 4 as as IN cord-297469-26d8o1xk 157 5 a a DT cord-297469-26d8o1xk 157 6 standard standard JJ cord-297469-26d8o1xk 157 7 drug drug NN cord-297469-26d8o1xk 157 8 to to TO cord-297469-26d8o1xk 157 9 evaluate evaluate VB cord-297469-26d8o1xk 157 10 whether whether IN cord-297469-26d8o1xk 157 11 or or CC cord-297469-26d8o1xk 157 12 not not RB cord-297469-26d8o1xk 157 13 ursolic ursolic JJ cord-297469-26d8o1xk 157 14 acid acid NN cord-297469-26d8o1xk 157 15 has have VBZ cord-297469-26d8o1xk 157 16 an an DT cord-297469-26d8o1xk 157 17 anti anti JJ cord-297469-26d8o1xk 157 18 - - JJ cord-297469-26d8o1xk 157 19 parasitic parasitic JJ cord-297469-26d8o1xk 157 20 effect effect NN cord-297469-26d8o1xk 157 21 and and CC cord-297469-26d8o1xk 157 22 activity activity NN cord-297469-26d8o1xk 157 23 against against IN cord-297469-26d8o1xk 157 24 T. t. NN cord-297469-26d8o1xk 157 25 gondii gondii NNP cord-297469-26d8o1xk 157 26 . . . cord-297469-26d8o1xk 158 1 The the DT cord-297469-26d8o1xk 158 2 compounds compound NNS cord-297469-26d8o1xk 158 3 were be VBD cord-297469-26d8o1xk 158 4 filtered filter VBN cord-297469-26d8o1xk 158 5 using use VBG cord-297469-26d8o1xk 158 6 0.2-µm 0.2-µm CD cord-297469-26d8o1xk 158 7 membrane membrane NN cord-297469-26d8o1xk 158 8 syringe syringe NN cord-297469-26d8o1xk 158 9 filters filter NNS cord-297469-26d8o1xk 158 10 ( ( -LRB- cord-297469-26d8o1xk 158 11 Roshi Roshi NNP cord-297469-26d8o1xk 158 12 Kaisha Kaisha NNP cord-297469-26d8o1xk 158 13 , , , cord-297469-26d8o1xk 158 14 Ltd. Ltd. NNP cord-297469-26d8o1xk 158 15 , , , cord-297469-26d8o1xk 158 16 Tokyo Tokyo NNP cord-297469-26d8o1xk 158 17 , , , cord-297469-26d8o1xk 158 18 Japan Japan NNP cord-297469-26d8o1xk 158 19 ) ) -RRB- cord-297469-26d8o1xk 158 20 before before IN cord-297469-26d8o1xk 158 21 use use NN cord-297469-26d8o1xk 158 22 , , , cord-297469-26d8o1xk 158 23 and and CC cord-297469-26d8o1xk 158 24 were be VBD cord-297469-26d8o1xk 158 25 stored store VBN cord-297469-26d8o1xk 158 26 at at IN cord-297469-26d8o1xk 158 27 −80 −80 NNP cord-297469-26d8o1xk 159 1 • • NNP cord-297469-26d8o1xk 160 1 C C NNP cord-297469-26d8o1xk 160 2 deep deep JJ cord-297469-26d8o1xk 160 3 - - HYPH cord-297469-26d8o1xk 160 4 freezer freezer NN cord-297469-26d8o1xk 160 5 until until IN cord-297469-26d8o1xk 160 6 use use NN cord-297469-26d8o1xk 160 7 . . . cord-297469-26d8o1xk 161 1 Macrophages macrophage NNS cord-297469-26d8o1xk 161 2 ( ( -LRB- cord-297469-26d8o1xk 161 3 Raw Raw NNP cord-297469-26d8o1xk 161 4 264.7 264.7 CD cord-297469-26d8o1xk 161 5 ) ) -RRB- cord-297469-26d8o1xk 161 6 , , , cord-297469-26d8o1xk 161 7 T t NN cord-297469-26d8o1xk 161 8 cells cell NNS cord-297469-26d8o1xk 161 9 ( ( -LRB- cord-297469-26d8o1xk 161 10 EL4 EL4 NNP cord-297469-26d8o1xk 161 11 ) ) -RRB- cord-297469-26d8o1xk 161 12 , , , cord-297469-26d8o1xk 161 13 B b NN cord-297469-26d8o1xk 161 14 cells cell NNS cord-297469-26d8o1xk 161 15 ( ( -LRB- cord-297469-26d8o1xk 161 16 FB2 FB2 NNP cord-297469-26d8o1xk 161 17 ) ) -RRB- cord-297469-26d8o1xk 161 18 , , , cord-297469-26d8o1xk 161 19 basophil basophil NNP cord-297469-26d8o1xk 161 20 cells cell NNS cord-297469-26d8o1xk 161 21 ( ( -LRB- cord-297469-26d8o1xk 161 22 RBL-2H3 rbl-2h3 NN cord-297469-26d8o1xk 161 23 ) ) -RRB- cord-297469-26d8o1xk 161 24 , , , cord-297469-26d8o1xk 161 25 and and CC cord-297469-26d8o1xk 161 26 normal normal JJ cord-297469-26d8o1xk 161 27 lung lung NN cord-297469-26d8o1xk 161 28 epithelial epithelial NN cord-297469-26d8o1xk 161 29 cells cell NNS cord-297469-26d8o1xk 161 30 ( ( -LRB- cord-297469-26d8o1xk 161 31 L2 L2 NNP cord-297469-26d8o1xk 161 32 ) ) -RRB- cord-297469-26d8o1xk 161 33 were be VBD cord-297469-26d8o1xk 161 34 purchased purchase VBN cord-297469-26d8o1xk 161 35 from from IN cord-297469-26d8o1xk 161 36 Korean Korean NNP cord-297469-26d8o1xk 161 37 Cell Cell NNP cord-297469-26d8o1xk 161 38 Line Line NNP cord-297469-26d8o1xk 161 39 Bank Bank NNP cord-297469-26d8o1xk 161 40 at at IN cord-297469-26d8o1xk 161 41 Seoul Seoul NNP cord-297469-26d8o1xk 161 42 National National NNP cord-297469-26d8o1xk 161 43 University University NNP cord-297469-26d8o1xk 161 44 and and CC cord-297469-26d8o1xk 161 45 American American NNP cord-297469-26d8o1xk 161 46 Type Type NNP cord-297469-26d8o1xk 161 47 Culture Culture NNP cord-297469-26d8o1xk 161 48 Collection Collection NNP cord-297469-26d8o1xk 162 1 ( ( -LRB- cord-297469-26d8o1xk 162 2 Manassas Manassas NNP cord-297469-26d8o1xk 162 3 , , , cord-297469-26d8o1xk 162 4 VA VA NNP cord-297469-26d8o1xk 162 5 , , , cord-297469-26d8o1xk 162 6 USA USA NNP cord-297469-26d8o1xk 162 7 ) ) -RRB- cord-297469-26d8o1xk 162 8 . . . cord-297469-26d8o1xk 163 1 The the DT cord-297469-26d8o1xk 163 2 cells cell NNS cord-297469-26d8o1xk 163 3 were be VBD cord-297469-26d8o1xk 163 4 cultured culture VBN cord-297469-26d8o1xk 163 5 in in IN cord-297469-26d8o1xk 163 6 RPMI RPMI NNP cord-297469-26d8o1xk 163 7 medium medium NN cord-297469-26d8o1xk 163 8 1640 1640 CD cord-297469-26d8o1xk 163 9 and and CC cord-297469-26d8o1xk 163 10 DMEM DMEM NNP cord-297469-26d8o1xk 163 11 containing contain VBG cord-297469-26d8o1xk 163 12 2 2 CD cord-297469-26d8o1xk 163 13 mM mm CD cord-297469-26d8o1xk 163 14 L l NN cord-297469-26d8o1xk 163 15 - - HYPH cord-297469-26d8o1xk 163 16 glutamine glutamine NN cord-297469-26d8o1xk 163 17 , , , cord-297469-26d8o1xk 163 18 supplemented supplement VBN cord-297469-26d8o1xk 163 19 with with IN cord-297469-26d8o1xk 163 20 15 15 CD cord-297469-26d8o1xk 163 21 % % NN cord-297469-26d8o1xk 163 22 decomplemented decomplemented JJ cord-297469-26d8o1xk 163 23 fetal fetal JJ cord-297469-26d8o1xk 163 24 bovine bovine NN cord-297469-26d8o1xk 163 25 serum serum NN cord-297469-26d8o1xk 163 26 ( ( -LRB- cord-297469-26d8o1xk 163 27 FBS FBS NNP cord-297469-26d8o1xk 163 28 ) ) -RRB- cord-297469-26d8o1xk 163 29 , , , cord-297469-26d8o1xk 163 30 penicillin penicillin NN cord-297469-26d8o1xk 163 31 ( ( -LRB- cord-297469-26d8o1xk 163 32 100 100 CD cord-297469-26d8o1xk 163 33 units unit NNS cord-297469-26d8o1xk 163 34 / / SYM cord-297469-26d8o1xk 163 35 mL mL NNP cord-297469-26d8o1xk 163 36 ) ) -RRB- cord-297469-26d8o1xk 163 37 , , , cord-297469-26d8o1xk 163 38 and and CC cord-297469-26d8o1xk 163 39 streptomycin streptomycin NNS cord-297469-26d8o1xk 163 40 ( ( -LRB- cord-297469-26d8o1xk 163 41 100 100 CD cord-297469-26d8o1xk 163 42 µg µg NN cord-297469-26d8o1xk 163 43 / / SYM cord-297469-26d8o1xk 163 44 mL mL NNP cord-297469-26d8o1xk 163 45 ) ) -RRB- cord-297469-26d8o1xk 163 46 in in IN cord-297469-26d8o1xk 163 47 a a DT cord-297469-26d8o1xk 163 48 humidified humidified JJ cord-297469-26d8o1xk 163 49 atmosphere atmosphere NN cord-297469-26d8o1xk 163 50 containing contain VBG cord-297469-26d8o1xk 163 51 5 5 CD cord-297469-26d8o1xk 163 52 % % NN cord-297469-26d8o1xk 163 53 CO co NN cord-297469-26d8o1xk 163 54 2 2 CD cord-297469-26d8o1xk 163 55 in in IN cord-297469-26d8o1xk 163 56 air air NN cord-297469-26d8o1xk 163 57 at at IN cord-297469-26d8o1xk 163 58 37 37 CD cord-297469-26d8o1xk 163 59 • • NN cord-297469-26d8o1xk 163 60 C. c. NN cord-297469-26d8o1xk 164 1 The the DT cord-297469-26d8o1xk 164 2 T. T. NNP cord-297469-26d8o1xk 164 3 gondii gondii NNP cord-297469-26d8o1xk 164 4 RH RH NNP cord-297469-26d8o1xk 164 5 was be VBD cord-297469-26d8o1xk 164 6 suspended suspend VBN cord-297469-26d8o1xk 164 7 with with IN cord-297469-26d8o1xk 164 8 1 1 CD cord-297469-26d8o1xk 164 9 × × NNP cord-297469-26d8o1xk 164 10 PBS PBS NNP cord-297469-26d8o1xk 164 11 , , , cord-297469-26d8o1xk 164 12 which which WDT cord-297469-26d8o1xk 164 13 was be VBD cord-297469-26d8o1xk 164 14 injected inject VBN cord-297469-26d8o1xk 164 15 in in IN cord-297469-26d8o1xk 164 16 the the DT cord-297469-26d8o1xk 164 17 abdominal abdominal JJ cord-297469-26d8o1xk 164 18 cavity cavity NN cord-297469-26d8o1xk 164 19 of of IN cord-297469-26d8o1xk 164 20 each each DT cord-297469-26d8o1xk 164 21 BALB BALB NNP cord-297469-26d8o1xk 164 22 - - HYPH cord-297469-26d8o1xk 164 23 c c NNP cord-297469-26d8o1xk 164 24 / / SYM cord-297469-26d8o1xk 164 25 mouse mouse NN cord-297469-26d8o1xk 164 26 . . . cord-297469-26d8o1xk 165 1 Five five CD cord-297469-26d8o1xk 165 2 days day NNS cord-297469-26d8o1xk 165 3 after after IN cord-297469-26d8o1xk 165 4 the the DT cord-297469-26d8o1xk 165 5 injection injection NN cord-297469-26d8o1xk 165 6 , , , cord-297469-26d8o1xk 165 7 T. T. NNP cord-297469-26d8o1xk 165 8 gondii gondii NNP cord-297469-26d8o1xk 165 9 was be VBD cord-297469-26d8o1xk 165 10 collected collect VBN cord-297469-26d8o1xk 165 11 from from IN cord-297469-26d8o1xk 165 12 the the DT cord-297469-26d8o1xk 165 13 peritoneal peritoneal JJ cord-297469-26d8o1xk 165 14 fluids fluid NNS cord-297469-26d8o1xk 165 15 of of IN cord-297469-26d8o1xk 165 16 mouse mouse NN cord-297469-26d8o1xk 165 17 kept keep VBN cord-297469-26d8o1xk 165 18 in in IN cord-297469-26d8o1xk 165 19 the the DT cord-297469-26d8o1xk 165 20 abdominal abdominal JJ cord-297469-26d8o1xk 165 21 cavities cavity NNS cord-297469-26d8o1xk 165 22 of of IN cord-297469-26d8o1xk 165 23 the the DT cord-297469-26d8o1xk 165 24 mice mouse NNS cord-297469-26d8o1xk 165 25 before before IN cord-297469-26d8o1xk 165 26 use use NN cord-297469-26d8o1xk 165 27 . . . cord-297469-26d8o1xk 166 1 In in IN cord-297469-26d8o1xk 166 2 the the DT cord-297469-26d8o1xk 166 3 in in FW cord-297469-26d8o1xk 166 4 vitro vitro FW cord-297469-26d8o1xk 166 5 study study NN cord-297469-26d8o1xk 166 6 , , , cord-297469-26d8o1xk 166 7 host host NN cord-297469-26d8o1xk 166 8 cells cell NNS cord-297469-26d8o1xk 166 9 were be VBD cord-297469-26d8o1xk 166 10 infected infect VBN cord-297469-26d8o1xk 166 11 with with IN cord-297469-26d8o1xk 166 12 tachyzoite tachyzoite NNP cord-297469-26d8o1xk 166 13 of of IN cord-297469-26d8o1xk 166 14 T. T. NNP cord-297469-26d8o1xk 166 15 gondii gondii NNP cord-297469-26d8o1xk 166 16 at at IN cord-297469-26d8o1xk 166 17 a a DT cord-297469-26d8o1xk 166 18 cell cell NN cord-297469-26d8o1xk 166 19 - - HYPH cord-297469-26d8o1xk 166 20 to to IN cord-297469-26d8o1xk 166 21 - - HYPH cord-297469-26d8o1xk 166 22 parasite parasite NN cord-297469-26d8o1xk 166 23 ratio ratio NN cord-297469-26d8o1xk 166 24 of of IN cord-297469-26d8o1xk 166 25 1:4 1:4 CD cord-297469-26d8o1xk 166 26 . . . cord-297469-26d8o1xk 167 1 The the DT cord-297469-26d8o1xk 167 2 inhibitory inhibitory JJ cord-297469-26d8o1xk 167 3 effect effect NN cord-297469-26d8o1xk 167 4 of of IN cord-297469-26d8o1xk 167 5 ursolic ursolic JJ cord-297469-26d8o1xk 167 6 acid acid NN cord-297469-26d8o1xk 167 7 against against IN cord-297469-26d8o1xk 167 8 T. T. NNP cord-297469-26d8o1xk 167 9 gondii gondii NNP cord-297469-26d8o1xk 167 10 was be VBD cord-297469-26d8o1xk 167 11 confirmed confirm VBN cord-297469-26d8o1xk 167 12 by by IN cord-297469-26d8o1xk 167 13 directly directly RB cord-297469-26d8o1xk 167 14 evaluating evaluate VBG cord-297469-26d8o1xk 167 15 the the DT cord-297469-26d8o1xk 167 16 viability viability NN cord-297469-26d8o1xk 167 17 of of IN cord-297469-26d8o1xk 167 18 T. t. NN cord-297469-26d8o1xk 167 19 gondii gondii NNP cord-297469-26d8o1xk 167 20 exposed expose VBN cord-297469-26d8o1xk 167 21 to to IN cord-297469-26d8o1xk 167 22 UA UA NNP cord-297469-26d8o1xk 167 23 and and CC cord-297469-26d8o1xk 167 24 SF SF NNP cord-297469-26d8o1xk 167 25 through through IN cord-297469-26d8o1xk 167 26 the the DT cord-297469-26d8o1xk 167 27 MTT MTT NNP cord-297469-26d8o1xk 167 28 assay assay NN cord-297469-26d8o1xk 167 29 . . . cord-297469-26d8o1xk 168 1 Briefly briefly RB cord-297469-26d8o1xk 168 2 , , , cord-297469-26d8o1xk 168 3 after after IN cord-297469-26d8o1xk 168 4 T. T. NNP cord-297469-26d8o1xk 168 5 gondii gondii NNP cord-297469-26d8o1xk 168 6 was be VBD cord-297469-26d8o1xk 168 7 seeded seed VBN cord-297469-26d8o1xk 168 8 in in IN cord-297469-26d8o1xk 168 9 a a DT cord-297469-26d8o1xk 168 10 24-well 24-well CD cord-297469-26d8o1xk 168 11 plate plate NN cord-297469-26d8o1xk 168 12 ( ( -LRB- cord-297469-26d8o1xk 168 13 8 8 CD cord-297469-26d8o1xk 168 14 × × NN cord-297469-26d8o1xk 168 15 10 10 CD cord-297469-26d8o1xk 168 16 6 6 CD cord-297469-26d8o1xk 168 17 /well /well , cord-297469-26d8o1xk 168 18 ) ) -RRB- cord-297469-26d8o1xk 168 19 , , , cord-297469-26d8o1xk 168 20 T. T. NNP cord-297469-26d8o1xk 168 21 gondii gondii NNP cord-297469-26d8o1xk 168 22 was be VBD cord-297469-26d8o1xk 168 23 incubated incubate VBN cord-297469-26d8o1xk 168 24 with with IN cord-297469-26d8o1xk 168 25 different different JJ cord-297469-26d8o1xk 168 26 concentrations concentration NNS cord-297469-26d8o1xk 168 27 ( ( -LRB- cord-297469-26d8o1xk 168 28 12.5 12.5 CD cord-297469-26d8o1xk 168 29 - - SYM cord-297469-26d8o1xk 168 30 400 400 CD cord-297469-26d8o1xk 168 31 µg µg NN cord-297469-26d8o1xk 168 32 / / SYM cord-297469-26d8o1xk 168 33 mL ml NN cord-297469-26d8o1xk 168 34 ) ) -RRB- cord-297469-26d8o1xk 168 35 of of IN cord-297469-26d8o1xk 168 36 UA UA NNP cord-297469-26d8o1xk 168 37 and and CC cord-297469-26d8o1xk 168 38 SF SF NNP cord-297469-26d8o1xk 168 39 for for IN cord-297469-26d8o1xk 168 40 24 24 CD cord-297469-26d8o1xk 168 41 h h NNP cord-297469-26d8o1xk 168 42 , , , cord-297469-26d8o1xk 168 43 respectively respectively RB cord-297469-26d8o1xk 168 44 . . . cord-297469-26d8o1xk 169 1 The the DT cord-297469-26d8o1xk 169 2 normal normal JJ cord-297469-26d8o1xk 169 3 lung lung NN cord-297469-26d8o1xk 169 4 cells cell NNS cord-297469-26d8o1xk 169 5 were be VBD cord-297469-26d8o1xk 169 6 infected infect VBN cord-297469-26d8o1xk 169 7 with with IN cord-297469-26d8o1xk 169 8 T. t. NN cord-297469-26d8o1xk 169 9 gondii gondii NNP cord-297469-26d8o1xk 169 10 ( ( -LRB- cord-297469-26d8o1xk 169 11 cells cell NNS cord-297469-26d8o1xk 169 12 : : : cord-297469-26d8o1xk 169 13 T. t. NN cord-297469-26d8o1xk 169 14 gondii gondii NNP cord-297469-26d8o1xk 169 15 = = SYM cord-297469-26d8o1xk 169 16 1:4 1:4 CD cord-297469-26d8o1xk 169 17 ) ) -RRB- cord-297469-26d8o1xk 169 18 , , , cord-297469-26d8o1xk 169 19 and and CC cord-297469-26d8o1xk 170 1 T. T. NNP cord-297469-26d8o1xk 170 2 gondii gondii NN cord-297469-26d8o1xk 170 3 - - HYPH cord-297469-26d8o1xk 170 4 infected infect VBN cord-297469-26d8o1xk 170 5 cells cell NNS cord-297469-26d8o1xk 170 6 were be VBD cord-297469-26d8o1xk 170 7 treated treat VBN cord-297469-26d8o1xk 170 8 with with IN cord-297469-26d8o1xk 170 9 different different JJ cord-297469-26d8o1xk 170 10 concentrations concentration NNS cord-297469-26d8o1xk 170 11 ( ( -LRB- cord-297469-26d8o1xk 170 12 12.5 12.5 CD cord-297469-26d8o1xk 170 13 - - SYM cord-297469-26d8o1xk 170 14 200 200 CD cord-297469-26d8o1xk 170 15 µg µg NN cord-297469-26d8o1xk 170 16 / / SYM cord-297469-26d8o1xk 170 17 mL mL NNP cord-297469-26d8o1xk 170 18 ) ) -RRB- cord-297469-26d8o1xk 170 19 of of IN cord-297469-26d8o1xk 170 20 ursolic ursolic JJ cord-297469-26d8o1xk 170 21 acid acid NNP cord-297469-26d8o1xk 170 22 ( ( -LRB- cord-297469-26d8o1xk 170 23 UA UA NNP cord-297469-26d8o1xk 170 24 ) ) -RRB- cord-297469-26d8o1xk 170 25 and and CC cord-297469-26d8o1xk 170 26 sulfadiazine sulfadiazine NNP cord-297469-26d8o1xk 170 27 ( ( -LRB- cord-297469-26d8o1xk 170 28 SF SF NNP cord-297469-26d8o1xk 170 29 ) ) -RRB- cord-297469-26d8o1xk 170 30 at at IN cord-297469-26d8o1xk 170 31 37 37 CD cord-297469-26d8o1xk 170 32 • • NN cord-297469-26d8o1xk 170 33 C C NNP cord-297469-26d8o1xk 170 34 for for IN cord-297469-26d8o1xk 170 35 24 24 CD cord-297469-26d8o1xk 170 36 h h NN cord-297469-26d8o1xk 170 37 , , , cord-297469-26d8o1xk 170 38 respectively respectively RB cord-297469-26d8o1xk 170 39 ; ; : cord-297469-26d8o1xk 170 40 then then RB cord-297469-26d8o1xk 170 41 their -PRON- PRP$ cord-297469-26d8o1xk 170 42 viabilities viability NNS cord-297469-26d8o1xk 170 43 were be VBD cord-297469-26d8o1xk 170 44 evaluated evaluate VBN cord-297469-26d8o1xk 170 45 by by IN cord-297469-26d8o1xk 170 46 MTT MTT NNP cord-297469-26d8o1xk 170 47 assay assay NN cord-297469-26d8o1xk 170 48 . . . cord-297469-26d8o1xk 171 1 It -PRON- PRP cord-297469-26d8o1xk 171 2 was be VBD cord-297469-26d8o1xk 171 3 to to TO cord-297469-26d8o1xk 171 4 be be VB cord-297469-26d8o1xk 171 5 determined determine VBN cord-297469-26d8o1xk 171 6 whether whether IN cord-297469-26d8o1xk 171 7 or or CC cord-297469-26d8o1xk 171 8 not not RB cord-297469-26d8o1xk 171 9 UA UA NNP cord-297469-26d8o1xk 171 10 has have VBZ cord-297469-26d8o1xk 171 11 anti anti JJ cord-297469-26d8o1xk 171 12 - - JJ cord-297469-26d8o1xk 171 13 parasitic parasitic JJ cord-297469-26d8o1xk 171 14 activity activity NN cord-297469-26d8o1xk 171 15 and/or and/or CC cord-297469-26d8o1xk 171 16 effect effect NN cord-297469-26d8o1xk 171 17 against against IN cord-297469-26d8o1xk 171 18 T. t. NN cord-297469-26d8o1xk 171 19 gondii gondii NNP cord-297469-26d8o1xk 171 20 . . . cord-297469-26d8o1xk 172 1 The the DT cord-297469-26d8o1xk 172 2 cells cell NNS cord-297469-26d8o1xk 172 3 were be VBD cord-297469-26d8o1xk 172 4 divided divide VBN cord-297469-26d8o1xk 172 5 into into IN cord-297469-26d8o1xk 172 6 normal normal JJ cord-297469-26d8o1xk 172 7 and and CC cord-297469-26d8o1xk 172 8 experimental experimental JJ cord-297469-26d8o1xk 172 9 groups group NNS cord-297469-26d8o1xk 172 10 , , , cord-297469-26d8o1xk 172 11 and and CC cord-297469-26d8o1xk 172 12 the the DT cord-297469-26d8o1xk 172 13 survival survival NN cord-297469-26d8o1xk 172 14 rate rate NN cord-297469-26d8o1xk 172 15 ( ( -LRB- cord-297469-26d8o1xk 172 16 SR SR NNP cord-297469-26d8o1xk 172 17 ) ) -RRB- cord-297469-26d8o1xk 172 18 of of IN cord-297469-26d8o1xk 172 19 T. T. NNP cord-297469-26d8o1xk 172 20 gondii gondii NNP cord-297469-26d8o1xk 172 21 was be VBD cord-297469-26d8o1xk 172 22 calculated calculate VBN cord-297469-26d8o1xk 172 23 as as IN cord-297469-26d8o1xk 172 24 follows follow VBZ cord-297469-26d8o1xk 172 25 : : : cord-297469-26d8o1xk 172 26 % % NN cord-297469-26d8o1xk 172 27 of of IN cord-297469-26d8o1xk 172 28 SR SR NNP cord-297469-26d8o1xk 172 29 = = NFP cord-297469-26d8o1xk 173 1 ( ( -LRB- cord-297469-26d8o1xk 173 2 OD OD NNP cord-297469-26d8o1xk 173 3 drug drug NN cord-297469-26d8o1xk 173 4 - - HYPH cord-297469-26d8o1xk 173 5 tested test VBN cord-297469-26d8o1xk 173 6 wells well NNS cord-297469-26d8o1xk 173 7 − − NNP cord-297469-26d8o1xk 173 8 OD OD NNP cord-297469-26d8o1xk 173 9 blank blank NN cord-297469-26d8o1xk 173 10 ) ) -RRB- cord-297469-26d8o1xk 173 11 /(OD /(OD . cord-297469-26d8o1xk 174 1 control control NNP cord-297469-26d8o1xk 174 2 − − NNP cord-297469-26d8o1xk 174 3 OD OD NNP cord-297469-26d8o1xk 174 4 blank blank NN cord-297469-26d8o1xk 174 5 ) ) -RRB- cord-297469-26d8o1xk 175 1 × × NNP cord-297469-26d8o1xk 175 2 100 100 CD cord-297469-26d8o1xk 175 3 . . . cord-297469-26d8o1xk 176 1 The the DT cord-297469-26d8o1xk 176 2 optical optical JJ cord-297469-26d8o1xk 176 3 density density NN cord-297469-26d8o1xk 176 4 ( ( -LRB- cord-297469-26d8o1xk 176 5 OD OD NNP cord-297469-26d8o1xk 176 6 ) ) -RRB- cord-297469-26d8o1xk 176 7 was be VBD cord-297469-26d8o1xk 176 8 measured measure VBN cord-297469-26d8o1xk 176 9 at at IN cord-297469-26d8o1xk 176 10 a a DT cord-297469-26d8o1xk 176 11 wavelength wavelength NN cord-297469-26d8o1xk 176 12 of of IN cord-297469-26d8o1xk 176 13 570 570 CD cord-297469-26d8o1xk 176 14 nm nm NN cord-297469-26d8o1xk 176 15 using use VBG cord-297469-26d8o1xk 176 16 an an DT cord-297469-26d8o1xk 176 17 ELISA ELISA NNP cord-297469-26d8o1xk 176 18 leader leader NN cord-297469-26d8o1xk 176 19 . . . cord-297469-26d8o1xk 177 1 The the DT cord-297469-26d8o1xk 177 2 inhibitory inhibitory JJ cord-297469-26d8o1xk 177 3 effect effect NN cord-297469-26d8o1xk 177 4 of of IN cord-297469-26d8o1xk 177 5 ursolic ursolic JJ cord-297469-26d8o1xk 177 6 acid acid NN cord-297469-26d8o1xk 177 7 against against IN cord-297469-26d8o1xk 177 8 the the DT cord-297469-26d8o1xk 177 9 viability viability NN cord-297469-26d8o1xk 177 10 of of IN cord-297469-26d8o1xk 177 11 T. t. NN cord-297469-26d8o1xk 177 12 gondii gondii NNP cord-297469-26d8o1xk 177 13 was be VBD cord-297469-26d8o1xk 177 14 evaluated evaluate VBN cord-297469-26d8o1xk 177 15 by by IN cord-297469-26d8o1xk 177 16 measuring measure VBG cord-297469-26d8o1xk 177 17 the the DT cord-297469-26d8o1xk 177 18 expression expression NN cord-297469-26d8o1xk 177 19 of of IN cord-297469-26d8o1xk 177 20 subcellular subcellular JJ cord-297469-26d8o1xk 177 21 organelles organelle NNS cord-297469-26d8o1xk 177 22 of of IN cord-297469-26d8o1xk 177 23 T. t. NN cord-297469-26d8o1xk 177 24 gondii gondii NN cord-297469-26d8o1xk 177 25 in in IN cord-297469-26d8o1xk 177 26 T. T. NNP cord-297469-26d8o1xk 177 27 gondii gondii NN cord-297469-26d8o1xk 177 28 - - HYPH cord-297469-26d8o1xk 177 29 infected infect VBN cord-297469-26d8o1xk 177 30 cells cell NNS cord-297469-26d8o1xk 177 31 exposed expose VBN cord-297469-26d8o1xk 177 32 to to IN cord-297469-26d8o1xk 177 33 UA UA NNP cord-297469-26d8o1xk 177 34 and and CC cord-297469-26d8o1xk 177 35 SF SF NNP cord-297469-26d8o1xk 177 36 . . . cord-297469-26d8o1xk 178 1 After after IN cord-297469-26d8o1xk 178 2 normal normal JJ cord-297469-26d8o1xk 178 3 lung lung NN cord-297469-26d8o1xk 178 4 cells cell NNS cord-297469-26d8o1xk 178 5 were be VBD cord-297469-26d8o1xk 178 6 seeded seed VBN cord-297469-26d8o1xk 178 7 in in IN cord-297469-26d8o1xk 178 8 a a DT cord-297469-26d8o1xk 178 9 6-well 6-well CD cord-297469-26d8o1xk 178 10 plate plate NN cord-297469-26d8o1xk 178 11 ( ( -LRB- cord-297469-26d8o1xk 178 12 4 4 CD cord-297469-26d8o1xk 178 13 × × NN cord-297469-26d8o1xk 178 14 10 10 CD cord-297469-26d8o1xk 178 15 5 5 CD cord-297469-26d8o1xk 178 16 /well /well , cord-297469-26d8o1xk 178 17 ) ) -RRB- cord-297469-26d8o1xk 178 18 , , , cord-297469-26d8o1xk 178 19 the the DT cord-297469-26d8o1xk 178 20 cells cell NNS cord-297469-26d8o1xk 178 21 were be VBD cord-297469-26d8o1xk 178 22 infected infect VBN cord-297469-26d8o1xk 178 23 with with IN cord-297469-26d8o1xk 178 24 T. t. NN cord-297469-26d8o1xk 178 25 gondii gondii NNP cord-297469-26d8o1xk 178 26 ( ( -LRB- cord-297469-26d8o1xk 178 27 1:4 1:4 CD cord-297469-26d8o1xk 178 28 , , , cord-297469-26d8o1xk 178 29 cells cell NNS cord-297469-26d8o1xk 178 30 / / SYM cord-297469-26d8o1xk 178 31 parasite parasite NN cord-297469-26d8o1xk 178 32 ratio ratio NN cord-297469-26d8o1xk 178 33 ) ) -RRB- cord-297469-26d8o1xk 178 34 , , , cord-297469-26d8o1xk 178 35 which which WDT cord-297469-26d8o1xk 178 36 was be VBD cord-297469-26d8o1xk 178 37 incubated incubate VBN cord-297469-26d8o1xk 178 38 with with IN cord-297469-26d8o1xk 178 39 different different JJ cord-297469-26d8o1xk 178 40 concentrations concentration NNS cord-297469-26d8o1xk 178 41 ( ( -LRB- cord-297469-26d8o1xk 178 42 50 50 CD cord-297469-26d8o1xk 178 43 - - SYM cord-297469-26d8o1xk 178 44 100 100 CD cord-297469-26d8o1xk 178 45 µg µg NN cord-297469-26d8o1xk 178 46 / / SYM cord-297469-26d8o1xk 178 47 mL ml NN cord-297469-26d8o1xk 178 48 ) ) -RRB- cord-297469-26d8o1xk 178 49 of of IN cord-297469-26d8o1xk 178 50 UA UA NNP cord-297469-26d8o1xk 178 51 and and CC cord-297469-26d8o1xk 178 52 SF SF NNP cord-297469-26d8o1xk 178 53 for for IN cord-297469-26d8o1xk 178 54 24 24 CD cord-297469-26d8o1xk 178 55 h h NNP cord-297469-26d8o1xk 178 56 respectively respectively RB cord-297469-26d8o1xk 178 57 , , , cord-297469-26d8o1xk 178 58 and and CC cord-297469-26d8o1xk 179 1 their -PRON- PRP$ cord-297469-26d8o1xk 179 2 total total JJ cord-297469-26d8o1xk 179 3 RNA RNA NNP cord-297469-26d8o1xk 179 4 was be VBD cord-297469-26d8o1xk 179 5 isolated isolate VBN cord-297469-26d8o1xk 179 6 from from IN cord-297469-26d8o1xk 179 7 T. T. NNP cord-297469-26d8o1xk 179 8 gondii gondii NNP cord-297469-26d8o1xk 179 9 strain strain NN cord-297469-26d8o1xk 179 10 using use VBG cord-297469-26d8o1xk 179 11 RNeasy RNeasy NNP cord-297469-26d8o1xk 179 12 Mini Mini NNP cord-297469-26d8o1xk 179 13 Kit kit NN cord-297469-26d8o1xk 179 14 ( ( -LRB- cord-297469-26d8o1xk 179 15 Qiagen Qiagen NNP cord-297469-26d8o1xk 179 16 , , , cord-297469-26d8o1xk 179 17 Hilden Hilden NNP cord-297469-26d8o1xk 179 18 , , , cord-297469-26d8o1xk 179 19 Germany Germany NNP cord-297469-26d8o1xk 179 20 ) ) -RRB- cord-297469-26d8o1xk 179 21 . . . cord-297469-26d8o1xk 180 1 Total Total NNP cord-297469-26d8o1xk 180 2 RNA RNA NNP cord-297469-26d8o1xk 180 3 was be VBD cord-297469-26d8o1xk 180 4 obtained obtain VBN cord-297469-26d8o1xk 180 5 from from IN cord-297469-26d8o1xk 180 6 untreated untreated JJ cord-297469-26d8o1xk 180 7 control control NN cord-297469-26d8o1xk 180 8 and and CC cord-297469-26d8o1xk 180 9 treated treat VBN cord-297469-26d8o1xk 180 10 groups group NNS cord-297469-26d8o1xk 180 11 following follow VBG cord-297469-26d8o1xk 180 12 the the DT cord-297469-26d8o1xk 180 13 manufacturer manufacturer NN cord-297469-26d8o1xk 180 14 's 's POS cord-297469-26d8o1xk 180 15 recommended recommend VBN cord-297469-26d8o1xk 180 16 procedure procedure NN cord-297469-26d8o1xk 180 17 , , , cord-297469-26d8o1xk 180 18 and and CC cord-297469-26d8o1xk 180 19 the the DT cord-297469-26d8o1xk 180 20 total total JJ cord-297469-26d8o1xk 180 21 RNA RNA NNP cord-297469-26d8o1xk 180 22 was be VBD cord-297469-26d8o1xk 180 23 quantified quantify VBN cord-297469-26d8o1xk 180 24 in in IN cord-297469-26d8o1xk 180 25 an an DT cord-297469-26d8o1xk 180 26 Eppendorf Eppendorf NNP cord-297469-26d8o1xk 180 27 BioSpectrometer BioSpectrometer NNP cord-297469-26d8o1xk 180 28 ( ( -LRB- cord-297469-26d8o1xk 180 29 Eppendorf Eppendorf NNP cord-297469-26d8o1xk 180 30 , , , cord-297469-26d8o1xk 180 31 Seoul Seoul NNP cord-297469-26d8o1xk 180 32 , , , cord-297469-26d8o1xk 180 33 Korea Korea NNP cord-297469-26d8o1xk 180 34 ) ) -RRB- cord-297469-26d8o1xk 180 35 . . . cord-297469-26d8o1xk 181 1 One one CD cord-297469-26d8o1xk 181 2 pair pair NN cord-297469-26d8o1xk 181 3 of of IN cord-297469-26d8o1xk 181 4 primers primer NNS cord-297469-26d8o1xk 181 5 was be VBD cord-297469-26d8o1xk 181 6 designed design VBN cord-297469-26d8o1xk 181 7 using use VBG cord-297469-26d8o1xk 181 8 the the DT cord-297469-26d8o1xk 181 9 Primer Primer NNP cord-297469-26d8o1xk 181 10 3 3 CD cord-297469-26d8o1xk 181 11 ( ( -LRB- cord-297469-26d8o1xk 181 12 version version NN cord-297469-26d8o1xk 181 13 4.1 4.1 CD cord-297469-26d8o1xk 181 14 ) ) -RRB- cord-297469-26d8o1xk 181 15 and and CC cord-297469-26d8o1xk 181 16 NCBI NCBI NNP cord-297469-26d8o1xk 181 17 primer primer NN cord-297469-26d8o1xk 181 18 - - HYPH cord-297469-26d8o1xk 181 19 blast blast NN cord-297469-26d8o1xk 181 20 according accord VBG cord-297469-26d8o1xk 181 21 to to IN cord-297469-26d8o1xk 181 22 the the DT cord-297469-26d8o1xk 181 23 sequence sequence NN cord-297469-26d8o1xk 181 24 of of IN cord-297469-26d8o1xk 181 25 the the DT cord-297469-26d8o1xk 181 26 selected select VBN cord-297469-26d8o1xk 181 27 specific specific JJ cord-297469-26d8o1xk 181 28 gene gene NN cord-297469-26d8o1xk 181 29 in in IN cord-297469-26d8o1xk 181 30 NCBI NCBI NNP cord-297469-26d8o1xk 181 31 GenBank GenBank NNP cord-297469-26d8o1xk 181 32 as as IN cord-297469-26d8o1xk 181 33 follows follow VBZ cord-297469-26d8o1xk 181 34 : : : cord-297469-26d8o1xk 182 1 T. T. NNP cord-297469-26d8o1xk 182 2 gondii gondii NNP cord-297469-26d8o1xk 182 3 MIC MIC NNP cord-297469-26d8o1xk 182 4 8 8 CD cord-297469-26d8o1xk 183 1 ( ( -LRB- cord-297469-26d8o1xk 183 2 accession accession NN cord-297469-26d8o1xk 183 3 number number NN cord-297469-26d8o1xk 183 4 : : : cord-297469-26d8o1xk 184 1 AF353165 AF353165 NNP cord-297469-26d8o1xk 184 2 , , , cord-297469-26d8o1xk 184 3 2055 2055 CD cord-297469-26d8o1xk 184 4 bp bp NNP cord-297469-26d8o1xk 184 5 ) ) -RRB- cord-297469-26d8o1xk 184 6 , , , cord-297469-26d8o1xk 184 7 ROP ROP NNP cord-297469-26d8o1xk 184 8 18 18 CD cord-297469-26d8o1xk 184 9 ( ( -LRB- cord-297469-26d8o1xk 184 10 accession accession NN cord-297469-26d8o1xk 184 11 number number NN cord-297469-26d8o1xk 184 12 : : : cord-297469-26d8o1xk 184 13 AM075204 AM075204 NNP cord-297469-26d8o1xk 184 14 , , , cord-297469-26d8o1xk 184 15 1665 1665 CD cord-297469-26d8o1xk 184 16 bp bp NNP cord-297469-26d8o1xk 184 17 ) ) -RRB- cord-297469-26d8o1xk 184 18 , , , cord-297469-26d8o1xk 184 19 IMC IMC NNP cord-297469-26d8o1xk 184 20 sub-3 sub-3 NNP cord-297469-26d8o1xk 184 21 ( ( -LRB- cord-297469-26d8o1xk 184 22 accession accession NN cord-297469-26d8o1xk 184 23 number number NN cord-297469-26d8o1xk 184 24 : : : cord-297469-26d8o1xk 184 25 HQ012579 hq012579 CD cord-297469-26d8o1xk 184 26 , , , cord-297469-26d8o1xk 184 27 495 495 CD cord-297469-26d8o1xk 184 28 bp bp NNP cord-297469-26d8o1xk 184 29 ) ) -RRB- cord-297469-26d8o1xk 184 30 , , , cord-297469-26d8o1xk 184 31 and and CC cord-297469-26d8o1xk 184 32 β β NN cord-297469-26d8o1xk 184 33 - - HYPH cord-297469-26d8o1xk 184 34 actin actin NNP cord-297469-26d8o1xk 184 35 ( ( -LRB- cord-297469-26d8o1xk 184 36 accession accession NN cord-297469-26d8o1xk 184 37 number number NN cord-297469-26d8o1xk 184 38 : : : cord-297469-26d8o1xk 184 39 NM031144 nm031144 NN cord-297469-26d8o1xk 184 40 , , , cord-297469-26d8o1xk 184 41 1128 1128 CD cord-297469-26d8o1xk 184 42 bp bp NNP cord-297469-26d8o1xk 184 43 ) ) -RRB- cord-297469-26d8o1xk 184 44 . . . cord-297469-26d8o1xk 185 1 The the DT cord-297469-26d8o1xk 185 2 specific specific JJ cord-297469-26d8o1xk 185 3 genes gene NNS cord-297469-26d8o1xk 185 4 of of IN cord-297469-26d8o1xk 185 5 T. t. NN cord-297469-26d8o1xk 185 6 gondii gondii NNP cord-297469-26d8o1xk 185 7 were be VBD cord-297469-26d8o1xk 185 8 synthesized synthesize VBN cord-297469-26d8o1xk 185 9 to to IN cord-297469-26d8o1xk 185 10 complementary complementary JJ cord-297469-26d8o1xk 185 11 DNA DNA NNP cord-297469-26d8o1xk 185 12 ( ( -LRB- cord-297469-26d8o1xk 185 13 cDNA cDNA NNP cord-297469-26d8o1xk 185 14 ) ) -RRB- cord-297469-26d8o1xk 185 15 through through IN cord-297469-26d8o1xk 185 16 one one CD cord-297469-26d8o1xk 185 17 - - HYPH cord-297469-26d8o1xk 185 18 step step NN cord-297469-26d8o1xk 185 19 RT RT NNP cord-297469-26d8o1xk 185 20 - - HYPH cord-297469-26d8o1xk 185 21 PCR PCR NNP cord-297469-26d8o1xk 185 22 kit kit NN cord-297469-26d8o1xk 185 23 ( ( -LRB- cord-297469-26d8o1xk 185 24 Bioneer Bioneer NNP cord-297469-26d8o1xk 185 25 , , , cord-297469-26d8o1xk 185 26 Daejeon Daejeon NNP cord-297469-26d8o1xk 185 27 , , , cord-297469-26d8o1xk 185 28 Korea Korea NNP cord-297469-26d8o1xk 185 29 ) ) -RRB- cord-297469-26d8o1xk 185 30 . . . cord-297469-26d8o1xk 186 1 The the DT cord-297469-26d8o1xk 186 2 cDNA cdna NN cord-297469-26d8o1xk 186 3 was be VBD cord-297469-26d8o1xk 186 4 analyzed analyze VBN cord-297469-26d8o1xk 186 5 by by IN cord-297469-26d8o1xk 186 6 electrophoresis electrophoresis NN cord-297469-26d8o1xk 186 7 in in IN cord-297469-26d8o1xk 186 8 a a DT cord-297469-26d8o1xk 186 9 1.2 1.2 CD cord-297469-26d8o1xk 186 10 % % NN cord-297469-26d8o1xk 186 11 ( ( -LRB- cord-297469-26d8o1xk 186 12 w w NN cord-297469-26d8o1xk 186 13 / / SYM cord-297469-26d8o1xk 186 14 v v NN cord-297469-26d8o1xk 186 15 ) ) -RRB- cord-297469-26d8o1xk 186 16 agarose agarose VBN cord-297469-26d8o1xk 186 17 gel gel NN cord-297469-26d8o1xk 186 18 containing contain VBG cord-297469-26d8o1xk 186 19 10 10 CD cord-297469-26d8o1xk 187 1 µg µg NNP cord-297469-26d8o1xk 187 2 / / SYM cord-297469-26d8o1xk 187 3 mL ml NN cord-297469-26d8o1xk 187 4 ethidium ethidium NN cord-297469-26d8o1xk 187 5 bromide bromide NN cord-297469-26d8o1xk 187 6 at at IN cord-297469-26d8o1xk 187 7 120 120 CD cord-297469-26d8o1xk 187 8 V v NN cord-297469-26d8o1xk 187 9 for for IN cord-297469-26d8o1xk 187 10 1 1 CD cord-297469-26d8o1xk 187 11 h h NN cord-297469-26d8o1xk 187 12 , , , cord-297469-26d8o1xk 187 13 which which WDT cord-297469-26d8o1xk 187 14 was be VBD cord-297469-26d8o1xk 187 15 visualized visualize VBN cord-297469-26d8o1xk 187 16 under under IN cord-297469-26d8o1xk 187 17 ultraviolet ultraviolet JJ cord-297469-26d8o1xk 187 18 illumination illumination NN cord-297469-26d8o1xk 187 19 . . . cord-297469-26d8o1xk 188 1 The the DT cord-297469-26d8o1xk 188 2 β β NN cord-297469-26d8o1xk 188 3 - - HYPH cord-297469-26d8o1xk 188 4 actin actin NNP cord-297469-26d8o1xk 188 5 was be VBD cord-297469-26d8o1xk 188 6 used use VBN cord-297469-26d8o1xk 188 7 as as IN cord-297469-26d8o1xk 188 8 an an DT cord-297469-26d8o1xk 188 9 internal internal JJ cord-297469-26d8o1xk 188 10 standard standard NN cord-297469-26d8o1xk 188 11 for for IN cord-297469-26d8o1xk 188 12 the the DT cord-297469-26d8o1xk 188 13 amount amount NN cord-297469-26d8o1xk 188 14 of of IN cord-297469-26d8o1xk 188 15 the the DT cord-297469-26d8o1xk 188 16 expression expression NN cord-297469-26d8o1xk 188 17 of of IN cord-297469-26d8o1xk 188 18 cDNA cdna NN cord-297469-26d8o1xk 188 19 present present JJ cord-297469-26d8o1xk 188 20 in in IN cord-297469-26d8o1xk 188 21 each each DT cord-297469-26d8o1xk 188 22 sample sample NN cord-297469-26d8o1xk 188 23 . . . cord-297469-26d8o1xk 189 1 The the DT cord-297469-26d8o1xk 189 2 groups group NNS cord-297469-26d8o1xk 189 3 were be VBD cord-297469-26d8o1xk 189 4 divided divide VBN cord-297469-26d8o1xk 189 5 into into IN cord-297469-26d8o1xk 189 6 the the DT cord-297469-26d8o1xk 189 7 untreated untreated JJ cord-297469-26d8o1xk 189 8 positive positive JJ cord-297469-26d8o1xk 189 9 group group NN cord-297469-26d8o1xk 189 10 ( ( -LRB- cord-297469-26d8o1xk 189 11 T. T. NNP cord-297469-26d8o1xk 189 12 gondii gondii NN cord-297469-26d8o1xk 189 13 - - HYPH cord-297469-26d8o1xk 189 14 infected infect VBN cord-297469-26d8o1xk 189 15 group group NN cord-297469-26d8o1xk 189 16 ) ) -RRB- cord-297469-26d8o1xk 189 17 and and CC cord-297469-26d8o1xk 189 18 experimental experimental JJ cord-297469-26d8o1xk 189 19 groups group NNS cord-297469-26d8o1xk 189 20 ( ( -LRB- cord-297469-26d8o1xk 189 21 UA UA NNP cord-297469-26d8o1xk 189 22 and and CC cord-297469-26d8o1xk 189 23 SF SF NNP cord-297469-26d8o1xk 189 24 - - HYPH cord-297469-26d8o1xk 189 25 treated treat VBN cord-297469-26d8o1xk 189 26 groups group NNS cord-297469-26d8o1xk 189 27 ) ) -RRB- cord-297469-26d8o1xk 189 28 . . . cord-297469-26d8o1xk 190 1 The the DT cord-297469-26d8o1xk 190 2 effect effect NN cord-297469-26d8o1xk 190 3 of of IN cord-297469-26d8o1xk 190 4 nitric nitric NN cord-297469-26d8o1xk 190 5 oxide oxide NN cord-297469-26d8o1xk 190 6 ( ( -LRB- cord-297469-26d8o1xk 190 7 NO no UH cord-297469-26d8o1xk 190 8 ) ) -RRB- cord-297469-26d8o1xk 190 9 and and CC cord-297469-26d8o1xk 190 10 reactive reactive JJ cord-297469-26d8o1xk 190 11 oxygen oxygen NN cord-297469-26d8o1xk 190 12 species specie NNS cord-297469-26d8o1xk 190 13 ( ( -LRB- cord-297469-26d8o1xk 190 14 ROS ROS NNP cord-297469-26d8o1xk 190 15 ) ) -RRB- cord-297469-26d8o1xk 190 16 production production NN cord-297469-26d8o1xk 190 17 of of IN cord-297469-26d8o1xk 190 18 ursolic ursolic JJ cord-297469-26d8o1xk 190 19 acid acid NN cord-297469-26d8o1xk 190 20 was be VBD cord-297469-26d8o1xk 190 21 confirmed confirm VBN cord-297469-26d8o1xk 190 22 by by IN cord-297469-26d8o1xk 190 23 measuring measure VBG cord-297469-26d8o1xk 190 24 NO NO NNP cord-297469-26d8o1xk 190 25 and and CC cord-297469-26d8o1xk 190 26 ROS ROS NNP cord-297469-26d8o1xk 190 27 production production NN cord-297469-26d8o1xk 190 28 in in IN cord-297469-26d8o1xk 190 29 T. T. NNP cord-297469-26d8o1xk 190 30 gondii gondii NNP cord-297469-26d8o1xk 190 31 - - HYPH cord-297469-26d8o1xk 190 32 infected infect VBN cord-297469-26d8o1xk 190 33 co co JJ cord-297469-26d8o1xk 190 34 - - JJ cord-297469-26d8o1xk 190 35 cultured cultured JJ cord-297469-26d8o1xk 190 36 cells cell NNS cord-297469-26d8o1xk 190 37 ( ( -LRB- cord-297469-26d8o1xk 190 38 macrophage macrophage NN cord-297469-26d8o1xk 190 39 and and CC cord-297469-26d8o1xk 190 40 basophil basophil NNP cord-297469-26d8o1xk 190 41 cells cell NNS cord-297469-26d8o1xk 190 42 ) ) -RRB- cord-297469-26d8o1xk 190 43 exposed expose VBN cord-297469-26d8o1xk 190 44 to to IN cord-297469-26d8o1xk 190 45 the the DT cord-297469-26d8o1xk 190 46 compounds compound NNS cord-297469-26d8o1xk 190 47 . . . cord-297469-26d8o1xk 191 1 The the DT cord-297469-26d8o1xk 191 2 cells cell NNS cord-297469-26d8o1xk 191 3 were be VBD cord-297469-26d8o1xk 191 4 divided divide VBN cord-297469-26d8o1xk 191 5 into into IN cord-297469-26d8o1xk 191 6 normal normal JJ cord-297469-26d8o1xk 191 7 and and CC cord-297469-26d8o1xk 191 8 experimental experimental JJ cord-297469-26d8o1xk 191 9 groups group NNS cord-297469-26d8o1xk 191 10 as as IN cord-297469-26d8o1xk 191 11 described describe VBN cord-297469-26d8o1xk 191 12 above above RB cord-297469-26d8o1xk 191 13 . . . cord-297469-26d8o1xk 192 1 Briefly briefly RB cord-297469-26d8o1xk 192 2 , , , cord-297469-26d8o1xk 192 3 after after IN cord-297469-26d8o1xk 192 4 the the DT cord-297469-26d8o1xk 192 5 co co NN cord-297469-26d8o1xk 192 6 - - NN cord-297469-26d8o1xk 192 7 culture culture NN cord-297469-26d8o1xk 192 8 cells cell NNS cord-297469-26d8o1xk 192 9 were be VBD cord-297469-26d8o1xk 192 10 seeded seed VBN cord-297469-26d8o1xk 192 11 in in IN cord-297469-26d8o1xk 192 12 a a DT cord-297469-26d8o1xk 192 13 96-well 96-well CD cord-297469-26d8o1xk 192 14 plate plate NN cord-297469-26d8o1xk 192 15 ( ( -LRB- cord-297469-26d8o1xk 192 16 1 1 CD cord-297469-26d8o1xk 192 17 × × NN cord-297469-26d8o1xk 192 18 10 10 CD cord-297469-26d8o1xk 192 19 5 5 CD cord-297469-26d8o1xk 192 20 /well /well , cord-297469-26d8o1xk 192 21 ) ) -RRB- cord-297469-26d8o1xk 192 22 , , , cord-297469-26d8o1xk 192 23 the the DT cord-297469-26d8o1xk 192 24 cells cell NNS cord-297469-26d8o1xk 192 25 were be VBD cord-297469-26d8o1xk 192 26 infected infect VBN cord-297469-26d8o1xk 192 27 with with IN cord-297469-26d8o1xk 192 28 T. t. NN cord-297469-26d8o1xk 192 29 gondii gondii NNP cord-297469-26d8o1xk 192 30 ( ( -LRB- cord-297469-26d8o1xk 192 31 1:4 1:4 CD cord-297469-26d8o1xk 192 32 , , , cord-297469-26d8o1xk 192 33 cells cell NNS cord-297469-26d8o1xk 192 34 / / SYM cord-297469-26d8o1xk 192 35 parasite parasite NN cord-297469-26d8o1xk 192 36 ratio ratio NN cord-297469-26d8o1xk 192 37 ) ) -RRB- cord-297469-26d8o1xk 192 38 , , , cord-297469-26d8o1xk 192 39 which which WDT cord-297469-26d8o1xk 192 40 was be VBD cord-297469-26d8o1xk 192 41 incubated incubate VBN cord-297469-26d8o1xk 192 42 with with IN cord-297469-26d8o1xk 192 43 different different JJ cord-297469-26d8o1xk 192 44 concentrations concentration NNS cord-297469-26d8o1xk 192 45 ( ( -LRB- cord-297469-26d8o1xk 192 46 25 25 CD cord-297469-26d8o1xk 192 47 - - SYM cord-297469-26d8o1xk 192 48 100 100 CD cord-297469-26d8o1xk 192 49 µg µg NN cord-297469-26d8o1xk 192 50 / / SYM cord-297469-26d8o1xk 192 51 mL ml NN cord-297469-26d8o1xk 192 52 ) ) -RRB- cord-297469-26d8o1xk 192 53 of of IN cord-297469-26d8o1xk 192 54 UA UA NNP cord-297469-26d8o1xk 192 55 and and CC cord-297469-26d8o1xk 192 56 SF SF NNP cord-297469-26d8o1xk 192 57 for for IN cord-297469-26d8o1xk 192 58 24 24 CD cord-297469-26d8o1xk 192 59 h h NNP cord-297469-26d8o1xk 192 60 , , , cord-297469-26d8o1xk 192 61 respectively respectively RB cord-297469-26d8o1xk 192 62 . . . cord-297469-26d8o1xk 193 1 The the DT cord-297469-26d8o1xk 193 2 NO no NN cord-297469-26d8o1xk 193 3 and and CC cord-297469-26d8o1xk 193 4 ROS ROS NNP cord-297469-26d8o1xk 193 5 production production NN cord-297469-26d8o1xk 193 6 were be VBD cord-297469-26d8o1xk 193 7 measured measure VBN cord-297469-26d8o1xk 193 8 in in IN cord-297469-26d8o1xk 193 9 the the DT cord-297469-26d8o1xk 193 10 control control NN cord-297469-26d8o1xk 193 11 and and CC cord-297469-26d8o1xk 193 12 treated treat VBN cord-297469-26d8o1xk 193 13 groups group NNS cord-297469-26d8o1xk 193 14 according accord VBG cord-297469-26d8o1xk 193 15 to to IN cord-297469-26d8o1xk 193 16 the the DT cord-297469-26d8o1xk 193 17 manufacturer manufacturer NN cord-297469-26d8o1xk 193 18 's 's POS cord-297469-26d8o1xk 193 19 instructions instruction NNS cord-297469-26d8o1xk 193 20 through through IN cord-297469-26d8o1xk 193 21 NO no NN cord-297469-26d8o1xk 193 22 and and CC cord-297469-26d8o1xk 193 23 ROS ROS NNP cord-297469-26d8o1xk 193 24 production production NN cord-297469-26d8o1xk 193 25 kits kit NNS cord-297469-26d8o1xk 193 26 ( ( -LRB- cord-297469-26d8o1xk 193 27 Cell Cell NNP cord-297469-26d8o1xk 193 28 Biolabs Biolabs NNP cord-297469-26d8o1xk 193 29 , , , cord-297469-26d8o1xk 194 1 Inc. Inc. NNP cord-297469-26d8o1xk 194 2 San San NNP cord-297469-26d8o1xk 194 3 Diego Diego NNP cord-297469-26d8o1xk 194 4 , , , cord-297469-26d8o1xk 194 5 CA CA NNP cord-297469-26d8o1xk 194 6 , , , cord-297469-26d8o1xk 194 7 USA USA NNP cord-297469-26d8o1xk 194 8 ) ) -RRB- cord-297469-26d8o1xk 194 9 respectively respectively RB cord-297469-26d8o1xk 194 10 . . . cord-297469-26d8o1xk 195 1 The the DT cord-297469-26d8o1xk 195 2 rates rate NNS cord-297469-26d8o1xk 195 3 of of IN cord-297469-26d8o1xk 195 4 NO no NN cord-297469-26d8o1xk 195 5 and and CC cord-297469-26d8o1xk 195 6 ROS ROS NNP cord-297469-26d8o1xk 195 7 production production NN cord-297469-26d8o1xk 195 8 were be VBD cord-297469-26d8o1xk 195 9 measured measure VBN cord-297469-26d8o1xk 195 10 using use VBG cord-297469-26d8o1xk 195 11 an an DT cord-297469-26d8o1xk 195 12 ELISA ELISA NNP cord-297469-26d8o1xk 195 13 microplate microplate NN cord-297469-26d8o1xk 195 14 leader leader NN cord-297469-26d8o1xk 195 15 ( ( -LRB- cord-297469-26d8o1xk 195 16 BioTek BioTek NNP cord-297469-26d8o1xk 195 17 Instruments Instruments NNP cord-297469-26d8o1xk 195 18 , , , cord-297469-26d8o1xk 195 19 Inc. Inc. NNP cord-297469-26d8o1xk 195 20 , , , cord-297469-26d8o1xk 195 21 Winooski Winooski NNP cord-297469-26d8o1xk 195 22 , , , cord-297469-26d8o1xk 195 23 VT VT NNP cord-297469-26d8o1xk 195 24 , , , cord-297469-26d8o1xk 195 25 USA USA NNP cord-297469-26d8o1xk 195 26 ) ) -RRB- cord-297469-26d8o1xk 195 27 . . . cord-297469-26d8o1xk 196 1 The the DT cord-297469-26d8o1xk 196 2 effect effect NN cord-297469-26d8o1xk 196 3 of of IN cord-297469-26d8o1xk 196 4 ursolic ursolic JJ cord-297469-26d8o1xk 196 5 acid acid NNP cord-297469-26d8o1xk 196 6 regarding regard VBG cord-297469-26d8o1xk 196 7 immunomodulatory immunomodulatory JJ cord-297469-26d8o1xk 196 8 action action NN cord-297469-26d8o1xk 196 9 was be VBD cord-297469-26d8o1xk 196 10 evaluated evaluate VBN cord-297469-26d8o1xk 196 11 by by IN cord-297469-26d8o1xk 196 12 measuring measure VBG cord-297469-26d8o1xk 196 13 the the DT cord-297469-26d8o1xk 196 14 expression expression NN cord-297469-26d8o1xk 196 15 of of IN cord-297469-26d8o1xk 196 16 cytokines cytokine NNS cord-297469-26d8o1xk 196 17 in in IN cord-297469-26d8o1xk 196 18 T. T. NNP cord-297469-26d8o1xk 196 19 gondii gondii NN cord-297469-26d8o1xk 196 20 - - HYPH cord-297469-26d8o1xk 196 21 infected infect VBN cord-297469-26d8o1xk 196 22 co co NN cord-297469-26d8o1xk 196 23 - - NN cord-297469-26d8o1xk 196 24 culture culture JJ cord-297469-26d8o1xk 196 25 immune immune JJ cord-297469-26d8o1xk 196 26 cells cell NNS cord-297469-26d8o1xk 196 27 ( ( -LRB- cord-297469-26d8o1xk 196 28 macrophage macrophage NN cord-297469-26d8o1xk 196 29 , , , cord-297469-26d8o1xk 196 30 T t NN cord-297469-26d8o1xk 196 31 cells cell NNS cord-297469-26d8o1xk 196 32 , , , cord-297469-26d8o1xk 196 33 B b NN cord-297469-26d8o1xk 196 34 cells cell NNS cord-297469-26d8o1xk 196 35 , , , cord-297469-26d8o1xk 196 36 and and CC cord-297469-26d8o1xk 196 37 basophil basophil NNP cord-297469-26d8o1xk 196 38 cells cell NNS cord-297469-26d8o1xk 196 39 ) ) -RRB- cord-297469-26d8o1xk 196 40 exposed expose VBN cord-297469-26d8o1xk 196 41 to to IN cord-297469-26d8o1xk 196 42 UA UA NNP cord-297469-26d8o1xk 196 43 and and CC cord-297469-26d8o1xk 196 44 SF SF NNP cord-297469-26d8o1xk 196 45 , , , cord-297469-26d8o1xk 196 46 respectively respectively RB cord-297469-26d8o1xk 196 47 . . . cord-297469-26d8o1xk 197 1 The the DT cord-297469-26d8o1xk 197 2 cells cell NNS cord-297469-26d8o1xk 197 3 were be VBD cord-297469-26d8o1xk 197 4 divided divide VBN cord-297469-26d8o1xk 197 5 into into IN cord-297469-26d8o1xk 197 6 normal normal JJ cord-297469-26d8o1xk 197 7 and and CC cord-297469-26d8o1xk 197 8 experimental experimental JJ cord-297469-26d8o1xk 197 9 groups group NNS cord-297469-26d8o1xk 197 10 . . . cord-297469-26d8o1xk 198 1 First first RB cord-297469-26d8o1xk 198 2 , , , cord-297469-26d8o1xk 198 3 the the DT cord-297469-26d8o1xk 198 4 macrophage macrophage NN cord-297469-26d8o1xk 198 5 and and CC cord-297469-26d8o1xk 198 6 basophil basophil NNP cord-297469-26d8o1xk 198 7 cells cell NNS cord-297469-26d8o1xk 198 8 were be VBD cord-297469-26d8o1xk 198 9 sequentially sequentially RB cord-297469-26d8o1xk 198 10 seeded seed VBN cord-297469-26d8o1xk 198 11 in in IN cord-297469-26d8o1xk 198 12 a a DT cord-297469-26d8o1xk 198 13 6-well 6-well CD cord-297469-26d8o1xk 198 14 plate plate NN cord-297469-26d8o1xk 198 15 ( ( -LRB- cord-297469-26d8o1xk 198 16 1 1 CD cord-297469-26d8o1xk 198 17 × × NN cord-297469-26d8o1xk 198 18 10 10 CD cord-297469-26d8o1xk 198 19 5 5 CD cord-297469-26d8o1xk 198 20 /well /well , cord-297469-26d8o1xk 198 21 ) ) -RRB- cord-297469-26d8o1xk 198 22 in in IN cord-297469-26d8o1xk 198 23 a a DT cord-297469-26d8o1xk 198 24 humidified humidified JJ cord-297469-26d8o1xk 198 25 atmosphere atmosphere NN cord-297469-26d8o1xk 198 26 containing contain VBG cord-297469-26d8o1xk 198 27 5 5 CD cord-297469-26d8o1xk 198 28 % % NN cord-297469-26d8o1xk 198 29 CO co NN cord-297469-26d8o1xk 198 30 2 2 CD cord-297469-26d8o1xk 198 31 in in IN cord-297469-26d8o1xk 198 32 air air NN cord-297469-26d8o1xk 198 33 at at IN cord-297469-26d8o1xk 198 34 37 37 CD cord-297469-26d8o1xk 198 35 • • NNS cord-297469-26d8o1xk 199 1 C. C. NNP cord-297469-26d8o1xk 199 2 Second Second NNP cord-297469-26d8o1xk 199 3 , , , cord-297469-26d8o1xk 199 4 T T NNP cord-297469-26d8o1xk 199 5 cells cell NNS cord-297469-26d8o1xk 199 6 and and CC cord-297469-26d8o1xk 199 7 B b NN cord-297469-26d8o1xk 199 8 cells cell NNS cord-297469-26d8o1xk 199 9 were be VBD cord-297469-26d8o1xk 199 10 additionally additionally RB cord-297469-26d8o1xk 199 11 seeded seed VBN cord-297469-26d8o1xk 199 12 in in IN cord-297469-26d8o1xk 199 13 the the DT cord-297469-26d8o1xk 199 14 plate plate NN cord-297469-26d8o1xk 199 15 ( ( -LRB- cord-297469-26d8o1xk 199 16 1 1 CD cord-297469-26d8o1xk 199 17 × × NN cord-297469-26d8o1xk 199 18 10 10 CD cord-297469-26d8o1xk 199 19 5 5 CD cord-297469-26d8o1xk 199 20 /well /well , cord-297469-26d8o1xk 199 21 ) ) -RRB- cord-297469-26d8o1xk 200 1 after after IN cord-297469-26d8o1xk 200 2 24 24 CD cord-297469-26d8o1xk 200 3 h. h. NN cord-297469-26d8o1xk 201 1 Namely namely RB cord-297469-26d8o1xk 201 2 , , , cord-297469-26d8o1xk 201 3 the the DT cord-297469-26d8o1xk 201 4 co co JJ cord-297469-26d8o1xk 201 5 - - JJ cord-297469-26d8o1xk 201 6 cultured cultured JJ cord-297469-26d8o1xk 201 7 immune immune JJ cord-297469-26d8o1xk 201 8 cells cell NNS cord-297469-26d8o1xk 201 9 were be VBD cord-297469-26d8o1xk 201 10 seeded seed VBN cord-297469-26d8o1xk 201 11 in in IN cord-297469-26d8o1xk 201 12 a a DT cord-297469-26d8o1xk 201 13 6-well 6-well CD cord-297469-26d8o1xk 201 14 plate plate NN cord-297469-26d8o1xk 201 15 ( ( -LRB- cord-297469-26d8o1xk 201 16 4 4 CD cord-297469-26d8o1xk 201 17 × × NN cord-297469-26d8o1xk 201 18 10 10 CD cord-297469-26d8o1xk 201 19 5 5 CD cord-297469-26d8o1xk 201 20 /well /well , cord-297469-26d8o1xk 201 21 ) ) -RRB- cord-297469-26d8o1xk 201 22 and and CC cord-297469-26d8o1xk 201 23 the the DT cord-297469-26d8o1xk 201 24 cells cell NNS cord-297469-26d8o1xk 201 25 were be VBD cord-297469-26d8o1xk 201 26 finally finally RB cord-297469-26d8o1xk 201 27 infected infect VBN cord-297469-26d8o1xk 201 28 with with IN cord-297469-26d8o1xk 201 29 T. t. NN cord-297469-26d8o1xk 201 30 gondii gondii NNP cord-297469-26d8o1xk 201 31 ( ( -LRB- cord-297469-26d8o1xk 201 32 1:4 1:4 CD cord-297469-26d8o1xk 201 33 , , , cord-297469-26d8o1xk 201 34 cells cell NNS cord-297469-26d8o1xk 201 35 / / SYM cord-297469-26d8o1xk 201 36 parasite parasite NN cord-297469-26d8o1xk 201 37 ratio ratio NN cord-297469-26d8o1xk 201 38 ) ) -RRB- cord-297469-26d8o1xk 201 39 after after IN cord-297469-26d8o1xk 201 40 24 24 CD cord-297469-26d8o1xk 201 41 h h NN cord-297469-26d8o1xk 201 42 , , , cord-297469-26d8o1xk 201 43 and and CC cord-297469-26d8o1xk 201 44 incubated incubate VBN cord-297469-26d8o1xk 201 45 with with IN cord-297469-26d8o1xk 201 46 different different JJ cord-297469-26d8o1xk 201 47 concentrations concentration NNS cord-297469-26d8o1xk 201 48 ( ( -LRB- cord-297469-26d8o1xk 201 49 25 25 CD cord-297469-26d8o1xk 201 50 - - SYM cord-297469-26d8o1xk 201 51 100 100 CD cord-297469-26d8o1xk 201 52 µg µg NN cord-297469-26d8o1xk 201 53 / / SYM cord-297469-26d8o1xk 201 54 mL ml NN cord-297469-26d8o1xk 201 55 ) ) -RRB- cord-297469-26d8o1xk 201 56 of of IN cord-297469-26d8o1xk 201 57 UA UA NNP cord-297469-26d8o1xk 201 58 and and CC cord-297469-26d8o1xk 201 59 SF SF NNP cord-297469-26d8o1xk 201 60 for for IN cord-297469-26d8o1xk 201 61 24 24 CD cord-297469-26d8o1xk 201 62 h h NNP cord-297469-26d8o1xk 201 63 , , , cord-297469-26d8o1xk 201 64 respectively respectively RB cord-297469-26d8o1xk 201 65 . . . cord-297469-26d8o1xk 202 1 The the DT cord-297469-26d8o1xk 202 2 cytokines cytokine NNS cord-297469-26d8o1xk 202 3 ( ( -LRB- cord-297469-26d8o1xk 202 4 TNF TNF NNP cord-297469-26d8o1xk 202 5 - - HYPH cord-297469-26d8o1xk 202 6 α α NNP cord-297469-26d8o1xk 202 7 , , , cord-297469-26d8o1xk 202 8 TGF TGF NNP cord-297469-26d8o1xk 202 9 - - HYPH cord-297469-26d8o1xk 202 10 β1 β1 NNP cord-297469-26d8o1xk 202 11 , , , cord-297469-26d8o1xk 202 12 interferon interferon NN cord-297469-26d8o1xk 202 13 - - HYPH cord-297469-26d8o1xk 202 14 β β NN cord-297469-26d8o1xk 202 15 , , , cord-297469-26d8o1xk 202 16 GM GM NNP cord-297469-26d8o1xk 202 17 - - HYPH cord-297469-26d8o1xk 202 18 CSF CSF NNP cord-297469-26d8o1xk 202 19 , , , cord-297469-26d8o1xk 202 20 IL-1β IL-1β NNP cord-297469-26d8o1xk 202 21 , , , cord-297469-26d8o1xk 202 22 IL-6 IL-6 NNP cord-297469-26d8o1xk 202 23 , , , cord-297469-26d8o1xk 202 24 IL-10 IL-10 NNP cord-297469-26d8o1xk 202 25 , , , cord-297469-26d8o1xk 202 26 and and CC cord-297469-26d8o1xk 202 27 IL-12 IL-12 NNP cord-297469-26d8o1xk 202 28 ) ) -RRB- cord-297469-26d8o1xk 202 29 were be VBD cord-297469-26d8o1xk 202 30 respectively respectively RB cord-297469-26d8o1xk 202 31 measured measure VBN cord-297469-26d8o1xk 202 32 in in IN cord-297469-26d8o1xk 202 33 normal normal JJ cord-297469-26d8o1xk 202 34 , , , cord-297469-26d8o1xk 202 35 infected infected JJ cord-297469-26d8o1xk 202 36 , , , cord-297469-26d8o1xk 202 37 and and CC cord-297469-26d8o1xk 202 38 treated treat VBN cord-297469-26d8o1xk 202 39 groups group NNS cord-297469-26d8o1xk 202 40 according accord VBG cord-297469-26d8o1xk 202 41 to to IN cord-297469-26d8o1xk 202 42 the the DT cord-297469-26d8o1xk 202 43 manufacturer manufacturer NN cord-297469-26d8o1xk 202 44 's 's POS cord-297469-26d8o1xk 202 45 instruction instruction NN cord-297469-26d8o1xk 202 46 through through IN cord-297469-26d8o1xk 202 47 cytokine cytokine NN cord-297469-26d8o1xk 202 48 ELISA ELISA NNP cord-297469-26d8o1xk 202 49 kits kit NNS cord-297469-26d8o1xk 202 50 ( ( -LRB- cord-297469-26d8o1xk 202 51 ThermoFisher ThermoFisher NNP cord-297469-26d8o1xk 202 52 Scientific Scientific NNP cord-297469-26d8o1xk 202 53 , , , cord-297469-26d8o1xk 202 54 San San NNP cord-297469-26d8o1xk 202 55 Diego Diego NNP cord-297469-26d8o1xk 202 56 , , , cord-297469-26d8o1xk 202 57 CA CA NNP cord-297469-26d8o1xk 202 58 , , , cord-297469-26d8o1xk 202 59 USA USA NNP cord-297469-26d8o1xk 202 60 ) ) -RRB- cord-297469-26d8o1xk 202 61 and and CC cord-297469-26d8o1xk 202 62 inflammatory inflammatory JJ cord-297469-26d8o1xk 202 63 multi multi JJ cord-297469-26d8o1xk 202 64 - - JJ cord-297469-26d8o1xk 202 65 cytokine cytokine JJ cord-297469-26d8o1xk 202 66 kits kit NNS cord-297469-26d8o1xk 202 67 ( ( -LRB- cord-297469-26d8o1xk 202 68 Qiagen Qiagen NNP cord-297469-26d8o1xk 202 69 , , , cord-297469-26d8o1xk 202 70 Hilden Hilden NNP cord-297469-26d8o1xk 202 71 , , , cord-297469-26d8o1xk 202 72 Germany Germany NNP cord-297469-26d8o1xk 202 73 ) ) -RRB- cord-297469-26d8o1xk 202 74 , , , cord-297469-26d8o1xk 202 75 and and CC cord-297469-26d8o1xk 202 76 the the DT cord-297469-26d8o1xk 202 77 untreated untreated JJ cord-297469-26d8o1xk 202 78 T. t. NN cord-297469-26d8o1xk 202 79 gondii gondii NN cord-297469-26d8o1xk 202 80 - - HYPH cord-297469-26d8o1xk 202 81 infected infect VBN cord-297469-26d8o1xk 202 82 cells cell NNS cord-297469-26d8o1xk 202 83 were be VBD cord-297469-26d8o1xk 202 84 used use VBN cord-297469-26d8o1xk 202 85 as as IN cord-297469-26d8o1xk 202 86 an an DT cord-297469-26d8o1xk 202 87 positive positive JJ cord-297469-26d8o1xk 202 88 group group NN cord-297469-26d8o1xk 202 89 . . . cord-297469-26d8o1xk 203 1 All all PDT cord-297469-26d8o1xk 203 2 the the DT cord-297469-26d8o1xk 203 3 results result NNS cord-297469-26d8o1xk 203 4 were be VBD cord-297469-26d8o1xk 203 5 expressed express VBN cord-297469-26d8o1xk 203 6 as as IN cord-297469-26d8o1xk 203 7 mean mean JJ cord-297469-26d8o1xk 203 8 ± ± NNP cord-297469-26d8o1xk 203 9 standard standard JJ cord-297469-26d8o1xk 203 10 deviation deviation NN cord-297469-26d8o1xk 203 11 ( ( -LRB- cord-297469-26d8o1xk 203 12 SD sd NN cord-297469-26d8o1xk 203 13 ) ) -RRB- cord-297469-26d8o1xk 203 14 of of IN cord-297469-26d8o1xk 203 15 three three CD cord-297469-26d8o1xk 203 16 independent independent JJ cord-297469-26d8o1xk 203 17 experiments experiment NNS cord-297469-26d8o1xk 203 18 . . . cord-297469-26d8o1xk 204 1 Statistical statistical JJ cord-297469-26d8o1xk 204 2 analysis analysis NN cord-297469-26d8o1xk 204 3 of of IN cord-297469-26d8o1xk 204 4 the the DT cord-297469-26d8o1xk 204 5 data datum NNS cord-297469-26d8o1xk 204 6 was be VBD cord-297469-26d8o1xk 204 7 performed perform VBN cord-297469-26d8o1xk 204 8 using use VBG cord-297469-26d8o1xk 204 9 Student Student NNP cord-297469-26d8o1xk 204 10 's 's POS cord-297469-26d8o1xk 204 11 t t NN cord-297469-26d8o1xk 204 12 - - HYPH cord-297469-26d8o1xk 204 13 test test NN cord-297469-26d8o1xk 204 14 and and CC cord-297469-26d8o1xk 204 15 analysis analysis NN cord-297469-26d8o1xk 204 16 of of IN cord-297469-26d8o1xk 204 17 variance variance NN cord-297469-26d8o1xk 204 18 ( ( -LRB- cord-297469-26d8o1xk 204 19 ANOVA ANOVA NNP cord-297469-26d8o1xk 204 20 ) ) -RRB- cord-297469-26d8o1xk 204 21 . . . cord-297469-26d8o1xk 205 1 A a DT cord-297469-26d8o1xk 205 2 value value NN cord-297469-26d8o1xk 205 3 of of IN cord-297469-26d8o1xk 205 4 * * NFP cord-297469-26d8o1xk 205 5 p p XX cord-297469-26d8o1xk 205 6 < < XX cord-297469-26d8o1xk 205 7 0.05 0.05 CD cord-297469-26d8o1xk 205 8 was be VBD cord-297469-26d8o1xk 205 9 considered consider VBN cord-297469-26d8o1xk 205 10 to to TO cord-297469-26d8o1xk 205 11 be be VB cord-297469-26d8o1xk 205 12 statistically statistically RB cord-297469-26d8o1xk 205 13 significant significant JJ cord-297469-26d8o1xk 205 14 . . . cord-297469-26d8o1xk 205 15 _SP cord-297469-26d8o1xk 206 1 The the DT cord-297469-26d8o1xk 206 2 authors author NNS cord-297469-26d8o1xk 206 3 declare declare VBP cord-297469-26d8o1xk 206 4 no no DT cord-297469-26d8o1xk 206 5 conflict conflict NN cord-297469-26d8o1xk 206 6 of of IN cord-297469-26d8o1xk 206 7 interest interest NN cord-297469-26d8o1xk 206 8 . . . cord-297469-26d8o1xk 207 1 The the DT cord-297469-26d8o1xk 207 2 following following JJ cord-297469-26d8o1xk 207 3 abbreviations abbreviation NNS cord-297469-26d8o1xk 207 4 are be VBP cord-297469-26d8o1xk 207 5 used use VBN cord-297469-26d8o1xk 207 6 in in IN cord-297469-26d8o1xk 207 7 this this DT cord-297469-26d8o1xk 207 8 manuscript manuscript NN cord-297469-26d8o1xk 207 9 : : : cord-297469-26d8o1xk 207 10 _SP cord-297469-26d8o1xk 207 11 Secretory secretory JJ cord-297469-26d8o1xk 207 12 traffic traffic NN cord-297469-26d8o1xk 207 13 in in IN cord-297469-26d8o1xk 207 14 the the DT cord-297469-26d8o1xk 207 15 eukaryotic eukaryotic JJ cord-297469-26d8o1xk 207 16 parasite parasite NN cord-297469-26d8o1xk 207 17 Toxoplasma toxoplasma NN cord-297469-26d8o1xk 207 18 gondii gondii NN cord-297469-26d8o1xk 207 19 : : : cord-297469-26d8o1xk 208 1 Less Less JJR cord-297469-26d8o1xk 208 2 is be VBZ cord-297469-26d8o1xk 208 3 more more RBR cord-297469-26d8o1xk 208 4 A a DT cord-297469-26d8o1xk 208 5 novel novel JJ cord-297469-26d8o1xk 208 6 family family NN cord-297469-26d8o1xk 208 7 of of IN cord-297469-26d8o1xk 208 8 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 208 9 IMC IMC NNP cord-297469-26d8o1xk 208 10 proteins protein NNS cord-297469-26d8o1xk 208 11 displays display VBZ cord-297469-26d8o1xk 208 12 a a DT cord-297469-26d8o1xk 208 13 hierarchical hierarchical JJ cord-297469-26d8o1xk 208 14 organization organization NN cord-297469-26d8o1xk 208 15 and and CC cord-297469-26d8o1xk 208 16 functions function NNS cord-297469-26d8o1xk 208 17 in in IN cord-297469-26d8o1xk 208 18 coordinating coordinate VBG cord-297469-26d8o1xk 208 19 parasite parasite NN cord-297469-26d8o1xk 208 20 division division NN cord-297469-26d8o1xk 209 1 The the DT cord-297469-26d8o1xk 209 2 inner inner JJ cord-297469-26d8o1xk 209 3 membrane membrane NN cord-297469-26d8o1xk 209 4 complex complex NN cord-297469-26d8o1xk 209 5 through through IN cord-297469-26d8o1xk 209 6 development development NN cord-297469-26d8o1xk 209 7 of of IN cord-297469-26d8o1xk 209 8 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 209 9 gondii gondii NNP cord-297469-26d8o1xk 209 10 and and CC cord-297469-26d8o1xk 209 11 Plasmodium Plasmodium NNP cord-297469-26d8o1xk 209 12 Differential Differential NNP cord-297469-26d8o1xk 209 13 Roles Roles NNP cord-297469-26d8o1xk 209 14 for for IN cord-297469-26d8o1xk 209 15 Inner inner JJ cord-297469-26d8o1xk 209 16 Membrane membrane NN cord-297469-26d8o1xk 209 17 Complex Complex NNP cord-297469-26d8o1xk 209 18 Proteins protein NNS cord-297469-26d8o1xk 209 19 across across IN cord-297469-26d8o1xk 209 20 Toxoplasma toxoplasma NN cord-297469-26d8o1xk 209 21 gondii gondii NN cord-297469-26d8o1xk 209 22 and and CC cord-297469-26d8o1xk 209 23 Sarcocystis Sarcocystis NNP cord-297469-26d8o1xk 209 24 neurona neurona NNP cord-297469-26d8o1xk 209 25 Development Development NNP cord-297469-26d8o1xk 210 1 TgTKL1 TgTKL1 NNP cord-297469-26d8o1xk 210 2 Is be VBZ cord-297469-26d8o1xk 210 3 a a DT cord-297469-26d8o1xk 210 4 Unique Unique NNP cord-297469-26d8o1xk 210 5 Plant Plant NNP cord-297469-26d8o1xk 210 6 - - HYPH cord-297469-26d8o1xk 210 7 Like Like NNP cord-297469-26d8o1xk 210 8 Nuclear Nuclear NNP cord-297469-26d8o1xk 210 9 Kinase Kinase NNP cord-297469-26d8o1xk 210 10 That that WDT cord-297469-26d8o1xk 210 11 Plays play VBZ cord-297469-26d8o1xk 210 12 an an DT cord-297469-26d8o1xk 210 13 Essential essential JJ cord-297469-26d8o1xk 210 14 Role role NN cord-297469-26d8o1xk 210 15 in in IN cord-297469-26d8o1xk 210 16 Acute acute JJ cord-297469-26d8o1xk 210 17 Toxoplasmosis toxoplasmosis NN cord-297469-26d8o1xk 210 18 Toxoplasma toxoplasma NN cord-297469-26d8o1xk 210 19 gondii gondii NN cord-297469-26d8o1xk 210 20 chromosomal chromosomal JJ cord-297469-26d8o1xk 210 21 passenger passenger NN cord-297469-26d8o1xk 210 22 complex complex NN cord-297469-26d8o1xk 211 1 is be VBZ cord-297469-26d8o1xk 211 2 essential essential JJ cord-297469-26d8o1xk 211 3 for for IN cord-297469-26d8o1xk 211 4 the the DT cord-297469-26d8o1xk 211 5 organization organization NN cord-297469-26d8o1xk 211 6 of of IN cord-297469-26d8o1xk 211 7 a a DT cord-297469-26d8o1xk 211 8 functional functional JJ cord-297469-26d8o1xk 211 9 mitotic mitotic JJ cord-297469-26d8o1xk 211 10 spindle spindle NN cord-297469-26d8o1xk 211 11 : : : cord-297469-26d8o1xk 212 1 A a DT cord-297469-26d8o1xk 212 2 prerequisite prerequisite NN cord-297469-26d8o1xk 212 3 for for IN cord-297469-26d8o1xk 212 4 productive productive JJ cord-297469-26d8o1xk 212 5 endodyogeny endodyogeny NN cord-297469-26d8o1xk 213 1 Signaling signal VBG cord-297469-26d8o1xk 213 2 during during IN cord-297469-26d8o1xk 213 3 the the DT cord-297469-26d8o1xk 213 4 invasion invasion NN cord-297469-26d8o1xk 213 5 of of IN cord-297469-26d8o1xk 213 6 host host NN cord-297469-26d8o1xk 213 7 cells cell NNS cord-297469-26d8o1xk 213 8 by by IN cord-297469-26d8o1xk 213 9 Toxoplasma toxoplasma NN cord-297469-26d8o1xk 213 10 gondii gondii NNP cord-297469-26d8o1xk 213 11 Intervacuolar Intervacuolar NNP cord-297469-26d8o1xk 213 12 Transport Transport NNP cord-297469-26d8o1xk 213 13 and and CC cord-297469-26d8o1xk 213 14 Unique Unique NNP cord-297469-26d8o1xk 213 15 Topology topology NN cord-297469-26d8o1xk 213 16 of of IN cord-297469-26d8o1xk 213 17 GRA14 GRA14 NNS cord-297469-26d8o1xk 213 18 , , , cord-297469-26d8o1xk 213 19 a a DT cord-297469-26d8o1xk 213 20 Novel Novel NNP cord-297469-26d8o1xk 213 21 Dense Dense NNP cord-297469-26d8o1xk 213 22 Granule Granule NNP cord-297469-26d8o1xk 213 23 Protein Protein NNP cord-297469-26d8o1xk 213 24 in in IN cord-297469-26d8o1xk 213 25 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 213 26 gondii gondii NNP cord-297469-26d8o1xk 213 27 Evaluation Evaluation NNP cord-297469-26d8o1xk 213 28 of of IN cord-297469-26d8o1xk 213 29 Anti anti JJ cord-297469-26d8o1xk 213 30 - - JJ cord-297469-26d8o1xk 213 31 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 213 32 gondii gondii NN cord-297469-26d8o1xk 213 33 Effect effect NN cord-297469-26d8o1xk 213 34 of of IN cord-297469-26d8o1xk 213 35 Ursolic Ursolic NNP cord-297469-26d8o1xk 213 36 Acid Acid NNP cord-297469-26d8o1xk 213 37 as as IN cord-297469-26d8o1xk 213 38 a a DT cord-297469-26d8o1xk 213 39 In in FW cord-297469-26d8o1xk 213 40 vitro vitro FW cord-297469-26d8o1xk 213 41 anti anti JJ cord-297469-26d8o1xk 213 42 - - JJ cord-297469-26d8o1xk 213 43 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 213 44 gondii gondii NN cord-297469-26d8o1xk 213 45 activity activity NN cord-297469-26d8o1xk 213 46 of of IN cord-297469-26d8o1xk 213 47 root root NN cord-297469-26d8o1xk 213 48 extract extract NN cord-297469-26d8o1xk 213 49 / / SYM cord-297469-26d8o1xk 213 50 fractions fraction NNS cord-297469-26d8o1xk 213 51 of of IN cord-297469-26d8o1xk 213 52 Eurycoma Eurycoma NNP cord-297469-26d8o1xk 213 53 longifolia longifolia NN cord-297469-26d8o1xk 213 54 Jack Jack NNP cord-297469-26d8o1xk 213 55 Imidazo[1,2-b]pyridazines Imidazo[1,2-b]pyridazines NNPS cord-297469-26d8o1xk 213 56 targeting target VBG cord-297469-26d8o1xk 213 57 Toxoplasma toxoplasma NN cord-297469-26d8o1xk 213 58 gondii gondii NN cord-297469-26d8o1xk 213 59 calcium calcium NN cord-297469-26d8o1xk 213 60 - - HYPH cord-297469-26d8o1xk 213 61 dependent dependent JJ cord-297469-26d8o1xk 213 62 protein protein NN cord-297469-26d8o1xk 213 63 kinase kinase VBD cord-297469-26d8o1xk 213 64 1 1 CD cord-297469-26d8o1xk 213 65 decrease decrease VBP cord-297469-26d8o1xk 213 66 the the DT cord-297469-26d8o1xk 213 67 parasite parasite NN cord-297469-26d8o1xk 213 68 burden burden NN cord-297469-26d8o1xk 213 69 in in IN cord-297469-26d8o1xk 213 70 mice mouse NNS cord-297469-26d8o1xk 213 71 with with IN cord-297469-26d8o1xk 213 72 acute acute JJ cord-297469-26d8o1xk 213 73 toxoplasmosis toxoplasmosis NN cord-297469-26d8o1xk 214 1 Licochalcone Licochalcone NNP cord-297469-26d8o1xk 214 2 A A NNP cord-297469-26d8o1xk 214 3 : : : cord-297469-26d8o1xk 214 4 An an DT cord-297469-26d8o1xk 214 5 effective effective JJ cord-297469-26d8o1xk 214 6 and and CC cord-297469-26d8o1xk 214 7 low low JJ cord-297469-26d8o1xk 214 8 - - HYPH cord-297469-26d8o1xk 214 9 toxicity toxicity NN cord-297469-26d8o1xk 214 10 compound compound NN cord-297469-26d8o1xk 214 11 against against IN cord-297469-26d8o1xk 214 12 Toxoplasma toxoplasma NN cord-297469-26d8o1xk 214 13 gondii gondii NN cord-297469-26d8o1xk 214 14 in in IN cord-297469-26d8o1xk 214 15 vitro vitro FW cord-297469-26d8o1xk 214 16 and and CC cord-297469-26d8o1xk 214 17 in in IN cord-297469-26d8o1xk 214 18 vivo vivo NNP cord-297469-26d8o1xk 214 19 Evaluation Evaluation NNP cord-297469-26d8o1xk 214 20 of of IN cord-297469-26d8o1xk 214 21 ATM ATM NNP cord-297469-26d8o1xk 215 1 Kinase Kinase NNP cord-297469-26d8o1xk 215 2 Inhibitor Inhibitor NNP cord-297469-26d8o1xk 215 3 KU-55933 ku-55933 RB cord-297469-26d8o1xk 215 4 as as IN cord-297469-26d8o1xk 215 5 Potential potential JJ cord-297469-26d8o1xk 215 6 Anti anti JJ cord-297469-26d8o1xk 215 7 - - JJ cord-297469-26d8o1xk 215 8 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 215 9 gondii gondii NN cord-297469-26d8o1xk 215 10 Agent Agent NNP cord-297469-26d8o1xk 216 1 In in IN cord-297469-26d8o1xk 216 2 vitro vitro FW cord-297469-26d8o1xk 216 3 evaluation evaluation NN cord-297469-26d8o1xk 216 4 of of IN cord-297469-26d8o1xk 216 5 b b NN cord-297469-26d8o1xk 216 6 - - HYPH cord-297469-26d8o1xk 216 7 carboline carboline NN cord-297469-26d8o1xk 216 8 alkaloids alkaloid NNS cord-297469-26d8o1xk 216 9 as as IN cord-297469-26d8o1xk 216 10 potential potential JJ cord-297469-26d8o1xk 216 11 anti anti JJ cord-297469-26d8o1xk 216 12 - - JJ cord-297469-26d8o1xk 216 13 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 216 14 agents agent NNS cord-297469-26d8o1xk 216 15 Identification identification NN cord-297469-26d8o1xk 216 16 of of IN cord-297469-26d8o1xk 216 17 small small JJ cord-297469-26d8o1xk 216 18 - - HYPH cord-297469-26d8o1xk 216 19 molecule molecule NN cord-297469-26d8o1xk 216 20 inhibitors inhibitor NNS cord-297469-26d8o1xk 216 21 of of IN cord-297469-26d8o1xk 216 22 Zika Zika NNP cord-297469-26d8o1xk 216 23 virus virus NN cord-297469-26d8o1xk 216 24 infection infection NN cord-297469-26d8o1xk 216 25 and and CC cord-297469-26d8o1xk 216 26 induced induce VBN cord-297469-26d8o1xk 216 27 neural neural JJ cord-297469-26d8o1xk 216 28 cell cell NN cord-297469-26d8o1xk 216 29 death death NN cord-297469-26d8o1xk 216 30 via via IN cord-297469-26d8o1xk 216 31 a a DT cord-297469-26d8o1xk 216 32 drug drug NN cord-297469-26d8o1xk 216 33 repurposing repurpose VBG cord-297469-26d8o1xk 216 34 screen screen NN cord-297469-26d8o1xk 216 35 Novel Novel NNP cord-297469-26d8o1xk 216 36 pharmacological pharmacological JJ cord-297469-26d8o1xk 216 37 activity activity NN cord-297469-26d8o1xk 216 38 of of IN cord-297469-26d8o1xk 216 39 artesunate artesunate NN cord-297469-26d8o1xk 216 40 and and CC cord-297469-26d8o1xk 216 41 artemisinin artemisinin NN cord-297469-26d8o1xk 216 42 : : : cord-297469-26d8o1xk 216 43 Their -PRON- PRP$ cord-297469-26d8o1xk 216 44 potential potential NN cord-297469-26d8o1xk 216 45 as as IN cord-297469-26d8o1xk 216 46 anti anti JJ cord-297469-26d8o1xk 216 47 - - JJ cord-297469-26d8o1xk 216 48 tubercular tubercular JJ cord-297469-26d8o1xk 216 49 agents agent NNS cord-297469-26d8o1xk 216 50 In in IN cord-297469-26d8o1xk 216 51 vitro vitro FW cord-297469-26d8o1xk 216 52 and and CC cord-297469-26d8o1xk 216 53 in in IN cord-297469-26d8o1xk 216 54 vivo vivo NN cord-297469-26d8o1xk 216 55 activities activity NNS cord-297469-26d8o1xk 216 56 of of IN cord-297469-26d8o1xk 216 57 the the DT cord-297469-26d8o1xk 216 58 nitroimidazole nitroimidazole NNP cord-297469-26d8o1xk 217 1 TBA-354 TBA-354 NNP cord-297469-26d8o1xk 217 2 against against IN cord-297469-26d8o1xk 217 3 Mycobacterium Mycobacterium NNP cord-297469-26d8o1xk 217 4 tuberculosis tuberculosis NN cord-297469-26d8o1xk 217 5 Evaluation Evaluation NNP cord-297469-26d8o1xk 217 6 of of IN cord-297469-26d8o1xk 217 7 anti anti JJ cord-297469-26d8o1xk 217 8 - - JJ cord-297469-26d8o1xk 217 9 tubercular tubercular JJ cord-297469-26d8o1xk 217 10 activity activity NN cord-297469-26d8o1xk 217 11 of of IN cord-297469-26d8o1xk 217 12 linolenic linolenic JJ cord-297469-26d8o1xk 217 13 acid acid NN cord-297469-26d8o1xk 217 14 and and CC cord-297469-26d8o1xk 217 15 conjugated conjugate VBN cord-297469-26d8o1xk 217 16 - - HYPH cord-297469-26d8o1xk 217 17 linoleic linoleic NN cord-297469-26d8o1xk 217 18 acid acid NN cord-297469-26d8o1xk 217 19 as as IN cord-297469-26d8o1xk 217 20 effective effective JJ cord-297469-26d8o1xk 217 21 inhibitors inhibitor NNS cord-297469-26d8o1xk 217 22 against against IN cord-297469-26d8o1xk 217 23 Mycobacterium Mycobacterium NNP cord-297469-26d8o1xk 217 24 tuberculosis tuberculosis NN cord-297469-26d8o1xk 217 25 . . . cord-297469-26d8o1xk 218 1 Asian Asian NNP cord-297469-26d8o1xk 218 2 Pac Pac NNP cord-297469-26d8o1xk 219 1 In in IN cord-297469-26d8o1xk 219 2 vitro vitro FW cord-297469-26d8o1xk 219 3 antileishmanial antileishmanial JJ cord-297469-26d8o1xk 219 4 activity activity NN cord-297469-26d8o1xk 219 5 of of IN cord-297469-26d8o1xk 219 6 Mexican mexican JJ cord-297469-26d8o1xk 219 7 medicinal medicinal JJ cord-297469-26d8o1xk 219 8 plants plant NNS cord-297469-26d8o1xk 219 9 Avian avian JJ cord-297469-26d8o1xk 219 10 coronavirus coronavirus NN cord-297469-26d8o1xk 219 11 infectious infectious JJ cord-297469-26d8o1xk 219 12 bronchitis bronchitis NN cord-297469-26d8o1xk 219 13 virus virus NN cord-297469-26d8o1xk 219 14 susceptibility susceptibility NN cord-297469-26d8o1xk 219 15 to to IN cord-297469-26d8o1xk 219 16 botanical botanical JJ cord-297469-26d8o1xk 219 17 oleoresins oleoresin NNS cord-297469-26d8o1xk 219 18 and and CC cord-297469-26d8o1xk 219 19 essential essential JJ cord-297469-26d8o1xk 219 20 oils oil NNS cord-297469-26d8o1xk 219 21 in in IN cord-297469-26d8o1xk 219 22 vitro vitro FW cord-297469-26d8o1xk 219 23 and and CC cord-297469-26d8o1xk 219 24 in in IN cord-297469-26d8o1xk 219 25 vivo vivo NNP cord-297469-26d8o1xk 219 26 New new JJ cord-297469-26d8o1xk 219 27 hybrid hybrid JJ cord-297469-26d8o1xk 219 28 trifluoromethylquinolines trifluoromethylquinoline NNS cord-297469-26d8o1xk 219 29 as as IN cord-297469-26d8o1xk 219 30 antiplasmo antiplasmo NN cord-297469-26d8o1xk 219 31 dium dium NNP cord-297469-26d8o1xk 219 32 agents agent NNS cord-297469-26d8o1xk 219 33 Agave Agave NNP cord-297469-26d8o1xk 219 34 sisalana sisalana NNS cord-297469-26d8o1xk 219 35 extract extract NN cord-297469-26d8o1xk 219 36 induces induce VBZ cord-297469-26d8o1xk 219 37 cell cell NN cord-297469-26d8o1xk 219 38 death death NN cord-297469-26d8o1xk 219 39 in in IN cord-297469-26d8o1xk 219 40 Aedes Aedes NNP cord-297469-26d8o1xk 219 41 aegypti aegypti NN cord-297469-26d8o1xk 219 42 hemocytes hemocyte VBZ cord-297469-26d8o1xk 219 43 increasing increase VBG cord-297469-26d8o1xk 219 44 nitric nitric JJ cord-297469-26d8o1xk 219 45 oxide oxide NN cord-297469-26d8o1xk 219 46 production production NN cord-297469-26d8o1xk 219 47 Ursolic Ursolic NNP cord-297469-26d8o1xk 219 48 acid acid NN cord-297469-26d8o1xk 219 49 improves improve VBZ cord-297469-26d8o1xk 219 50 diabetic diabetic JJ cord-297469-26d8o1xk 219 51 nephropathy nephropathy NN cord-297469-26d8o1xk 219 52 via via IN cord-297469-26d8o1xk 219 53 suppression suppression NN cord-297469-26d8o1xk 219 54 of of IN cord-297469-26d8o1xk 219 55 oxidative oxidative JJ cord-297469-26d8o1xk 219 56 stress stress NN cord-297469-26d8o1xk 219 57 and and CC cord-297469-26d8o1xk 219 58 inflammation inflammation NN cord-297469-26d8o1xk 219 59 in in IN cord-297469-26d8o1xk 219 60 streptozotocin streptozotocin NN cord-297469-26d8o1xk 219 61 - - HYPH cord-297469-26d8o1xk 219 62 induced induce VBN cord-297469-26d8o1xk 219 63 rats rat NNS cord-297469-26d8o1xk 219 64 Ursolic Ursolic NNP cord-297469-26d8o1xk 219 65 acid acid NN cord-297469-26d8o1xk 219 66 alleviates alleviate VBZ cord-297469-26d8o1xk 219 67 inflammation inflammation NN cord-297469-26d8o1xk 219 68 and and CC cord-297469-26d8o1xk 219 69 against against IN cord-297469-26d8o1xk 219 70 diabetes diabetes NN cord-297469-26d8o1xk 219 71 - - HYPH cord-297469-26d8o1xk 219 72 induced induce VBN cord-297469-26d8o1xk 219 73 nephropathy nephropathy NN cord-297469-26d8o1xk 219 74 through through IN cord-297469-26d8o1xk 219 75 TLR4-mediated tlr4-mediated JJ cord-297469-26d8o1xk 219 76 inflammatory inflammatory JJ cord-297469-26d8o1xk 219 77 pathway pathway NN cord-297469-26d8o1xk 219 78 Oral oral JJ cord-297469-26d8o1xk 219 79 supplementation supplementation NN cord-297469-26d8o1xk 219 80 with with IN cord-297469-26d8o1xk 219 81 ursolic ursolic JJ cord-297469-26d8o1xk 219 82 acid acid NN cord-297469-26d8o1xk 219 83 ameliorates ameliorate VBZ cord-297469-26d8o1xk 219 84 sepsis sepsis NN cord-297469-26d8o1xk 219 85 - - HYPH cord-297469-26d8o1xk 219 86 induced induce VBN cord-297469-26d8o1xk 219 87 acute acute JJ cord-297469-26d8o1xk 219 88 kidney kidney NN cord-297469-26d8o1xk 219 89 injury injury NN cord-297469-26d8o1xk 219 90 in in IN cord-297469-26d8o1xk 219 91 a a DT cord-297469-26d8o1xk 219 92 mouse mouse NN cord-297469-26d8o1xk 219 93 model model NN cord-297469-26d8o1xk 219 94 by by IN cord-297469-26d8o1xk 219 95 inhibiting inhibit VBG cord-297469-26d8o1xk 219 96 oxidative oxidative JJ cord-297469-26d8o1xk 219 97 stress stress NN cord-297469-26d8o1xk 219 98 and and CC cord-297469-26d8o1xk 219 99 inflammatory inflammatory JJ cord-297469-26d8o1xk 219 100 responses response NNS cord-297469-26d8o1xk 220 1 Pharmacokinetics Pharmacokinetics NNP cord-297469-26d8o1xk 220 2 and and CC cord-297469-26d8o1xk 220 3 Pharmacodynamics Pharmacodynamics NNPS cord-297469-26d8o1xk 220 4 of of IN cord-297469-26d8o1xk 220 5 the the DT cord-297469-26d8o1xk 220 6 Triterpenoid Triterpenoid NNP cord-297469-26d8o1xk 220 7 Ursolic Ursolic NNP cord-297469-26d8o1xk 220 8 Acid Acid NNP cord-297469-26d8o1xk 220 9 in in IN cord-297469-26d8o1xk 220 10 Regulating regulate VBG cord-297469-26d8o1xk 220 11 the the DT cord-297469-26d8o1xk 220 12 Antioxidant Antioxidant NNP cord-297469-26d8o1xk 220 13 , , , cord-297469-26d8o1xk 220 14 Anti anti JJ cord-297469-26d8o1xk 220 15 - - JJ cord-297469-26d8o1xk 220 16 inflammatory inflammatory JJ cord-297469-26d8o1xk 220 17 , , , cord-297469-26d8o1xk 220 18 and and CC cord-297469-26d8o1xk 220 19 Epigenetic epigenetic JJ cord-297469-26d8o1xk 220 20 Gene Gene NNP cord-297469-26d8o1xk 220 21 Responses Responses NNPS cord-297469-26d8o1xk 220 22 in in IN cord-297469-26d8o1xk 220 23 Rat Rat NNP cord-297469-26d8o1xk 220 24 Leukocytes Leukocytes NNP cord-297469-26d8o1xk 220 25 Ursolic Ursolic NNP cord-297469-26d8o1xk 220 26 Acid Acid NNP cord-297469-26d8o1xk 220 27 Induces induce VBZ cord-297469-26d8o1xk 220 28 Apoptosis Apoptosis NNP cord-297469-26d8o1xk 220 29 in in IN cord-297469-26d8o1xk 220 30 Colorectal Colorectal NNP cord-297469-26d8o1xk 220 31 Cancer Cancer NNP cord-297469-26d8o1xk 220 32 Cells cell NNS cord-297469-26d8o1xk 221 1 Partially partially RB cord-297469-26d8o1xk 221 2 via via IN cord-297469-26d8o1xk 221 3 Upregulation Upregulation NNP cord-297469-26d8o1xk 221 4 of of IN cord-297469-26d8o1xk 221 5 MicroRNA-4500 MicroRNA-4500 NNP cord-297469-26d8o1xk 221 6 and and CC cord-297469-26d8o1xk 221 7 Inhibition Inhibition NNP cord-297469-26d8o1xk 221 8 of of IN cord-297469-26d8o1xk 221 9 JAK2 JAK2 NNP cord-297469-26d8o1xk 222 1 /STAT3 /STAT3 . cord-297469-26d8o1xk 223 1 Phosphorylation Phosphorylation NNP cord-297469-26d8o1xk 223 2 Ursolic Ursolic NNP cord-297469-26d8o1xk 223 3 Acid Acid NNP cord-297469-26d8o1xk 223 4 Promotes promote VBZ cord-297469-26d8o1xk 223 5 the the DT cord-297469-26d8o1xk 223 6 Sensitization Sensitization NNP cord-297469-26d8o1xk 223 7 of of IN cord-297469-26d8o1xk 223 8 rhTRAIL rhTRAIL NNP cord-297469-26d8o1xk 223 9 - - HYPH cord-297469-26d8o1xk 223 10 resistant resistant JJ cord-297469-26d8o1xk 223 11 Triple triple JJ cord-297469-26d8o1xk 223 12 - - HYPH cord-297469-26d8o1xk 223 13 negative negative JJ cord-297469-26d8o1xk 223 14 Breast Breast NNP cord-297469-26d8o1xk 223 15 Cancer Cancer NNP cord-297469-26d8o1xk 223 16 Ursolic Ursolic NNP cord-297469-26d8o1xk 223 17 acid acid NN cord-297469-26d8o1xk 224 1 elicits elicit VBZ cord-297469-26d8o1xk 224 2 intrinsic intrinsic JJ cord-297469-26d8o1xk 224 3 apoptotic apoptotic JJ cord-297469-26d8o1xk 224 4 machinery machinery NN cord-297469-26d8o1xk 224 5 by by IN cord-297469-26d8o1xk 224 6 downregulating downregulate VBG cord-297469-26d8o1xk 224 7 the the DT cord-297469-26d8o1xk 224 8 phosphorylation phosphorylation NN cord-297469-26d8o1xk 224 9 of of IN cord-297469-26d8o1xk 224 10 AKT AKT NNP cord-297469-26d8o1xk 224 11 / / SYM cord-297469-26d8o1xk 224 12 BAD bad JJ cord-297469-26d8o1xk 224 13 signaling signal VBG cord-297469-26d8o1xk 224 14 in in IN cord-297469-26d8o1xk 224 15 human human JJ cord-297469-26d8o1xk 224 16 cisplatin cisplatin NN cord-297469-26d8o1xk 224 17 - - HYPH cord-297469-26d8o1xk 224 18 resistant resistant JJ cord-297469-26d8o1xk 224 19 oral oral JJ cord-297469-26d8o1xk 224 20 cancer cancer NN cord-297469-26d8o1xk 224 21 CAR car NN cord-297469-26d8o1xk 224 22 cells cell NNS cord-297469-26d8o1xk 225 1 Ursolic Ursolic NNP cord-297469-26d8o1xk 225 2 acid acid NN cord-297469-26d8o1xk 225 3 activates activate VBZ cord-297469-26d8o1xk 225 4 the the DT cord-297469-26d8o1xk 225 5 apoptosis apoptosis NN cord-297469-26d8o1xk 225 6 of of IN cord-297469-26d8o1xk 225 7 prostate prostate NN cord-297469-26d8o1xk 225 8 cancer cancer NN cord-297469-26d8o1xk 225 9 via via IN cord-297469-26d8o1xk 225 10 ROCK ROCK NNP cord-297469-26d8o1xk 225 11 / / SYM cord-297469-26d8o1xk 225 12 PTEN PTEN NNP cord-297469-26d8o1xk 225 13 mediated mediate VBD cord-297469-26d8o1xk 225 14 mitochondrial mitochondrial JJ cord-297469-26d8o1xk 225 15 translocation translocation NN cord-297469-26d8o1xk 225 16 of of IN cord-297469-26d8o1xk 225 17 cofilin-1 cofilin-1 NNP cord-297469-26d8o1xk 226 1 The the DT cord-297469-26d8o1xk 226 2 Pleiotropic Pleiotropic NNP cord-297469-26d8o1xk 226 3 Antibacterial Antibacterial NNP cord-297469-26d8o1xk 226 4 Mechanisms Mechanisms NNPS cord-297469-26d8o1xk 226 5 of of IN cord-297469-26d8o1xk 226 6 Ursolic Ursolic NNP cord-297469-26d8o1xk 226 7 Acid Acid NNP cord-297469-26d8o1xk 226 8 against against IN cord-297469-26d8o1xk 226 9 Methicillin Methicillin NNP cord-297469-26d8o1xk 226 10 - - HYPH cord-297469-26d8o1xk 226 11 Resistant resistant JJ cord-297469-26d8o1xk 226 12 Staphylococcus Staphylococcus NNP cord-297469-26d8o1xk 226 13 aureus aureus NN cord-297469-26d8o1xk 226 14 ( ( -LRB- cord-297469-26d8o1xk 227 1 MRSA MRSA NNP cord-297469-26d8o1xk 227 2 ) ) -RRB- cord-297469-26d8o1xk 227 3 Ursolic Ursolic NNP cord-297469-26d8o1xk 227 4 and and CC cord-297469-26d8o1xk 227 5 oleanolic oleanolic NN cord-297469-26d8o1xk 227 6 acids acid NNS cord-297469-26d8o1xk 227 7 as as IN cord-297469-26d8o1xk 227 8 antimicrobial antimicrobial JJ cord-297469-26d8o1xk 227 9 and and CC cord-297469-26d8o1xk 227 10 immunomodulatory immunomodulatory JJ cord-297469-26d8o1xk 227 11 compounds compound NNS cord-297469-26d8o1xk 227 12 for for IN cord-297469-26d8o1xk 227 13 tuberculosis tuberculosis NN cord-297469-26d8o1xk 227 14 treatment treatment NN cord-297469-26d8o1xk 227 15 Antibacterial Antibacterial NNP cord-297469-26d8o1xk 227 16 and and CC cord-297469-26d8o1xk 227 17 Synergistic Synergistic NNP cord-297469-26d8o1xk 227 18 Activity Activity NNP cord-297469-26d8o1xk 227 19 of of IN cord-297469-26d8o1xk 227 20 Pentacyclic Pentacyclic NNP cord-297469-26d8o1xk 227 21 Triterpenoids Triterpenoids NNP cord-297469-26d8o1xk 227 22 Isolated isolate VBN cord-297469-26d8o1xk 227 23 from from IN cord-297469-26d8o1xk 227 24 Alstonia Alstonia NNP cord-297469-26d8o1xk 227 25 scholaris scholaris JJ cord-297469-26d8o1xk 227 26 Therapeutic therapeutic JJ cord-297469-26d8o1xk 227 27 effect effect NN cord-297469-26d8o1xk 227 28 of of IN cord-297469-26d8o1xk 227 29 ursolic ursolic JJ cord-297469-26d8o1xk 227 30 acid acid NN cord-297469-26d8o1xk 227 31 in in IN cord-297469-26d8o1xk 227 32 experimental experimental JJ cord-297469-26d8o1xk 227 33 visceral visceral JJ cord-297469-26d8o1xk 227 34 leishmaniasis leishmaniasis NN cord-297469-26d8o1xk 227 35 Anti Anti NNP cord-297469-26d8o1xk 227 36 - - NNP cord-297469-26d8o1xk 227 37 Trichomonas Trichomonas NNP cord-297469-26d8o1xk 227 38 vaginalis vaginalis NN cord-297469-26d8o1xk 227 39 activity activity NN cord-297469-26d8o1xk 227 40 of of IN cord-297469-26d8o1xk 227 41 ursolic ursolic JJ cord-297469-26d8o1xk 227 42 acid acid NN cord-297469-26d8o1xk 227 43 derivative derivative NN cord-297469-26d8o1xk 227 44 : : : cord-297469-26d8o1xk 227 45 A a DT cord-297469-26d8o1xk 227 46 promising promising JJ cord-297469-26d8o1xk 227 47 alternative alternative NN cord-297469-26d8o1xk 228 1 Azithromycin azithromycin NN cord-297469-26d8o1xk 228 2 and and CC cord-297469-26d8o1xk 228 3 spiramycin spiramycin NNS cord-297469-26d8o1xk 228 4 induce induce VBP cord-297469-26d8o1xk 228 5 anti anti JJ cord-297469-26d8o1xk 228 6 - - JJ cord-297469-26d8o1xk 228 7 inflammatory inflammatory JJ cord-297469-26d8o1xk 228 8 response response NN cord-297469-26d8o1xk 228 9 in in IN cord-297469-26d8o1xk 228 10 human human JJ cord-297469-26d8o1xk 228 11 trophoblastic trophoblastic NNP cord-297469-26d8o1xk 228 12 ( ( -LRB- cord-297469-26d8o1xk 228 13 BeWo BeWo NNP cord-297469-26d8o1xk 228 14 ) ) -RRB- cord-297469-26d8o1xk 228 15 cells cell NNS cord-297469-26d8o1xk 228 16 infected infect VBN cord-297469-26d8o1xk 228 17 by by IN cord-297469-26d8o1xk 228 18 Toxoplasma toxoplasma NN cord-297469-26d8o1xk 228 19 gondii gondii NNS cord-297469-26d8o1xk 228 20 but but CC cord-297469-26d8o1xk 228 21 are be VBP cord-297469-26d8o1xk 228 22 able able JJ cord-297469-26d8o1xk 228 23 to to TO cord-297469-26d8o1xk 228 24 control control VB cord-297469-26d8o1xk 228 25 infection infection NN cord-297469-26d8o1xk 228 26 Anti anti JJ cord-297469-26d8o1xk 228 27 - - JJ cord-297469-26d8o1xk 228 28 parasitic parasitic JJ cord-297469-26d8o1xk 228 29 effect effect NN cord-297469-26d8o1xk 228 30 on on IN cord-297469-26d8o1xk 228 31 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 228 32 gondii gondii NN cord-297469-26d8o1xk 228 33 induced induce VBN cord-297469-26d8o1xk 228 34 by by IN cord-297469-26d8o1xk 228 35 BnSP-7 BnSP-7 NNP cord-297469-26d8o1xk 228 36 , , , cord-297469-26d8o1xk 228 37 a a DT cord-297469-26d8o1xk 228 38 Lys49-phospholipase lys49-phospholipase NN cord-297469-26d8o1xk 228 39 A2 A2 NNP cord-297469-26d8o1xk 228 40 homologue homologue NN cord-297469-26d8o1xk 228 41 from from IN cord-297469-26d8o1xk 228 42 Bothrops Bothrops NNP cord-297469-26d8o1xk 228 43 pauloensis pauloensis NN cord-297469-26d8o1xk 228 44 venom venom NN cord-297469-26d8o1xk 228 45 Sterculic Sterculic NNP cord-297469-26d8o1xk 228 46 Acid Acid NNP cord-297469-26d8o1xk 228 47 and and CC cord-297469-26d8o1xk 228 48 Its -PRON- PRP$ cord-297469-26d8o1xk 228 49 Analogues analogue NNS cord-297469-26d8o1xk 229 1 Are be VBP cord-297469-26d8o1xk 229 2 Potent potent JJ cord-297469-26d8o1xk 229 3 Inhibitors Inhibitors NNPS cord-297469-26d8o1xk 229 4 of of IN cord-297469-26d8o1xk 229 5 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 229 6 gondii gondii NNP cord-297469-26d8o1xk 229 7 Modulation modulation NN cord-297469-26d8o1xk 229 8 of of IN cord-297469-26d8o1xk 229 9 host host NN cord-297469-26d8o1xk 229 10 HIF-1α hif-1α NN cord-297469-26d8o1xk 229 11 activity activity NN cord-297469-26d8o1xk 229 12 and and CC cord-297469-26d8o1xk 230 1 the the DT cord-297469-26d8o1xk 230 2 tryptophan tryptophan NN cord-297469-26d8o1xk 230 3 pathway pathway NN cord-297469-26d8o1xk 230 4 contributes contribute VBZ cord-297469-26d8o1xk 230 5 to to IN cord-297469-26d8o1xk 230 6 the the DT cord-297469-26d8o1xk 230 7 anti anti JJ cord-297469-26d8o1xk 230 8 - - JJ cord-297469-26d8o1xk 230 9 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 230 10 gondii gondii NN cord-297469-26d8o1xk 230 11 potential potential NN cord-297469-26d8o1xk 230 12 of of IN cord-297469-26d8o1xk 230 13 nanoparticles nanoparticle NNS cord-297469-26d8o1xk 231 1 Pravastatin pravastatin NN cord-297469-26d8o1xk 231 2 and and CC cord-297469-26d8o1xk 231 3 simvastatin simvastatin NN cord-297469-26d8o1xk 231 4 inhibit inhibit VBP cord-297469-26d8o1xk 231 5 the the DT cord-297469-26d8o1xk 231 6 adhesion adhesion NN cord-297469-26d8o1xk 231 7 , , , cord-297469-26d8o1xk 231 8 replication replication NN cord-297469-26d8o1xk 231 9 and and CC cord-297469-26d8o1xk 231 10 proliferation proliferation NN cord-297469-26d8o1xk 231 11 of of IN cord-297469-26d8o1xk 231 12 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 231 13 gondii gondii NN cord-297469-26d8o1xk 231 14 ( ( -LRB- cord-297469-26d8o1xk 231 15 RH RH NNP cord-297469-26d8o1xk 231 16 strain strain NN cord-297469-26d8o1xk 231 17 ) ) -RRB- cord-297469-26d8o1xk 231 18 in in IN cord-297469-26d8o1xk 232 1 HeLa HeLa NNP cord-297469-26d8o1xk 232 2 cells cell NNS cord-297469-26d8o1xk 232 3 Extracts Extracts NNPS cord-297469-26d8o1xk 232 4 of of IN cord-297469-26d8o1xk 232 5 Tectona Tectona NNP cord-297469-26d8o1xk 232 6 grandis grandis NN cord-297469-26d8o1xk 232 7 and and CC cord-297469-26d8o1xk 232 8 Vernonia Vernonia NNP cord-297469-26d8o1xk 232 9 amygdalina amygdalina NNP cord-297469-26d8o1xk 232 10 have have VBP cord-297469-26d8o1xk 232 11 anti anti JJ cord-297469-26d8o1xk 232 12 - - JJ cord-297469-26d8o1xk 232 13 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 233 1 and and CC cord-297469-26d8o1xk 233 2 pro pro JJ cord-297469-26d8o1xk 233 3 - - JJ cord-297469-26d8o1xk 233 4 inflammatory inflammatory JJ cord-297469-26d8o1xk 233 5 properties property NNS cord-297469-26d8o1xk 233 6 in in IN cord-297469-26d8o1xk 233 7 vitro vitro FW cord-297469-26d8o1xk 233 8 Synthesis synthesis NN cord-297469-26d8o1xk 233 9 and and CC cord-297469-26d8o1xk 233 10 evaluation evaluation NN cord-297469-26d8o1xk 233 11 of of IN cord-297469-26d8o1xk 233 12 novel novel JJ cord-297469-26d8o1xk 233 13 arctigenin arctigenin NNP cord-297469-26d8o1xk 233 14 derivatives derivative NNS cord-297469-26d8o1xk 233 15 as as IN cord-297469-26d8o1xk 233 16 potential potential JJ cord-297469-26d8o1xk 233 17 anti anti JJ cord-297469-26d8o1xk 233 18 - - JJ cord-297469-26d8o1xk 233 19 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 233 20 gondii gondii NN cord-297469-26d8o1xk 233 21 agents agent NNS cord-297469-26d8o1xk 233 22 Rhoptries Rhoptries NNP cord-297469-26d8o1xk 233 23 are be VBP cord-297469-26d8o1xk 233 24 major major JJ cord-297469-26d8o1xk 233 25 players player NNS cord-297469-26d8o1xk 233 26 in in IN cord-297469-26d8o1xk 233 27 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 233 28 gondii gondii NNP cord-297469-26d8o1xk 233 29 invasion invasion NN cord-297469-26d8o1xk 233 30 and and CC cord-297469-26d8o1xk 233 31 host host NN cord-297469-26d8o1xk 233 32 cell cell NN cord-297469-26d8o1xk 233 33 interaction interaction NN cord-297469-26d8o1xk 233 34 Export Export NNP cord-297469-26d8o1xk 233 35 of of IN cord-297469-26d8o1xk 233 36 a a DT cord-297469-26d8o1xk 233 37 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 233 38 gondii gondii NNP cord-297469-26d8o1xk 233 39 rhoptry rhoptry NN cord-297469-26d8o1xk 233 40 neck neck NN cord-297469-26d8o1xk 233 41 protein protein NN cord-297469-26d8o1xk 233 42 complex complex NN cord-297469-26d8o1xk 233 43 at at IN cord-297469-26d8o1xk 233 44 the the DT cord-297469-26d8o1xk 233 45 host host NN cord-297469-26d8o1xk 233 46 cell cell NN cord-297469-26d8o1xk 233 47 membrane membrane NN cord-297469-26d8o1xk 233 48 to to TO cord-297469-26d8o1xk 233 49 form form VB cord-297469-26d8o1xk 233 50 the the DT cord-297469-26d8o1xk 233 51 moving move VBG cord-297469-26d8o1xk 233 52 junction junction NN cord-297469-26d8o1xk 233 53 during during IN cord-297469-26d8o1xk 233 54 invasion invasion NN cord-297469-26d8o1xk 233 55 Host host NN cord-297469-26d8o1xk 233 56 - - HYPH cord-297469-26d8o1xk 233 57 parasite parasite NN cord-297469-26d8o1xk 233 58 interactions interaction NNS cord-297469-26d8o1xk 233 59 : : : cord-297469-26d8o1xk 234 1 An an DT cord-297469-26d8o1xk 234 2 intimate intimate JJ cord-297469-26d8o1xk 234 3 epigenetic epigenetic JJ cord-297469-26d8o1xk 234 4 relationship relationship NN cord-297469-26d8o1xk 235 1 Efficient efficient JJ cord-297469-26d8o1xk 235 2 invasion invasion NN cord-297469-26d8o1xk 235 3 by by IN cord-297469-26d8o1xk 235 4 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 235 5 depends depend VBZ cord-297469-26d8o1xk 235 6 on on IN cord-297469-26d8o1xk 235 7 the the DT cord-297469-26d8o1xk 235 8 subversion subversion NN cord-297469-26d8o1xk 235 9 of of IN cord-297469-26d8o1xk 235 10 host host NN cord-297469-26d8o1xk 235 11 protein protein NN cord-297469-26d8o1xk 235 12 networks network NNS cord-297469-26d8o1xk 235 13 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 235 14 gondii gondii NNP cord-297469-26d8o1xk 235 15 RON4 RON4 NNP cord-297469-26d8o1xk 235 16 binds bind VBZ cord-297469-26d8o1xk 235 17 to to IN cord-297469-26d8o1xk 235 18 heparan heparan NN cord-297469-26d8o1xk 235 19 sulfate sulfate NN cord-297469-26d8o1xk 235 20 on on IN cord-297469-26d8o1xk 235 21 the the DT cord-297469-26d8o1xk 235 22 host host NN cord-297469-26d8o1xk 235 23 cell cell NN cord-297469-26d8o1xk 235 24 surface surface NN cord-297469-26d8o1xk 235 25 Toxoplasmosis toxoplasmosis NN cord-297469-26d8o1xk 235 26 in in IN cord-297469-26d8o1xk 235 27 pregnancy pregnancy NN cord-297469-26d8o1xk 235 28 : : : cord-297469-26d8o1xk 235 29 Prevention prevention NN cord-297469-26d8o1xk 235 30 , , , cord-297469-26d8o1xk 235 31 screening screening NN cord-297469-26d8o1xk 235 32 , , , cord-297469-26d8o1xk 235 33 and and CC cord-297469-26d8o1xk 235 34 treatment treatment NN cord-297469-26d8o1xk 235 35 Fetomaternal Fetomaternal NNP cord-297469-26d8o1xk 235 36 and and CC cord-297469-26d8o1xk 235 37 Pediatric Pediatric NNP cord-297469-26d8o1xk 235 38 Toxoplasmosis Toxoplasmosis NNP cord-297469-26d8o1xk 235 39 Encephalitis Encephalitis NNP cord-297469-26d8o1xk 235 40 is be VBZ cord-297469-26d8o1xk 235 41 mediated mediate VBN cord-297469-26d8o1xk 235 42 by by IN cord-297469-26d8o1xk 235 43 ROP18 ROP18 NNPS cord-297469-26d8o1xk 235 44 of of IN cord-297469-26d8o1xk 235 45 Toxoplasma toxoplasma JJ cord-297469-26d8o1xk 235 46 gondii gondii NN cord-297469-26d8o1xk 235 47 , , , cord-297469-26d8o1xk 235 48 a a DT cord-297469-26d8o1xk 235 49 severe severe JJ cord-297469-26d8o1xk 235 50 pathogen pathogen NN cord-297469-26d8o1xk 235 51 in in IN cord-297469-26d8o1xk 235 52 AIDS AIDS NNP cord-297469-26d8o1xk 235 53 patients patient NNS cord-297469-26d8o1xk 236 1 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 236 2 gondii gondii NNP cord-297469-26d8o1xk 236 3 IgG igg NN cord-297469-26d8o1xk 236 4 Seroprevalence Seroprevalence NNP cord-297469-26d8o1xk 236 5 in in IN cord-297469-26d8o1xk 236 6 Patients Patients NNP cord-297469-26d8o1xk 236 7 with with IN cord-297469-26d8o1xk 236 8 HIV HIV NNP cord-297469-26d8o1xk 236 9 / / SYM cord-297469-26d8o1xk 236 10 AIDS AIDS NNP cord-297469-26d8o1xk 236 11 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 236 12 gondii gondii NN cord-297469-26d8o1xk 236 13 - - HYPH cord-297469-26d8o1xk 236 14 induced induce VBN cord-297469-26d8o1xk 236 15 activation activation NN cord-297469-26d8o1xk 236 16 of of IN cord-297469-26d8o1xk 236 17 EGFR EGFR NNP cord-297469-26d8o1xk 236 18 prevents prevent VBZ cord-297469-26d8o1xk 236 19 autophagy autophagy NN cord-297469-26d8o1xk 236 20 protein protein NN cord-297469-26d8o1xk 236 21 - - HYPH cord-297469-26d8o1xk 236 22 mediated mediate VBN cord-297469-26d8o1xk 236 23 killing killing NN cord-297469-26d8o1xk 236 24 of of IN cord-297469-26d8o1xk 236 25 the the DT cord-297469-26d8o1xk 236 26 parasite parasite NN cord-297469-26d8o1xk 236 27 Toxoplasma toxoplasma NN cord-297469-26d8o1xk 236 28 gondii gondii NN cord-297469-26d8o1xk 236 29 infection infection NN cord-297469-26d8o1xk 236 30 confers confer VBZ cord-297469-26d8o1xk 236 31 resistance resistance NN cord-297469-26d8o1xk 236 32 against against IN cord-297469-26d8o1xk 236 33 BimS BimS NNP cord-297469-26d8o1xk 236 34 - - HYPH cord-297469-26d8o1xk 236 35 induced induce VBN cord-297469-26d8o1xk 236 36 apoptosis apoptosis NN cord-297469-26d8o1xk 236 37 by by IN cord-297469-26d8o1xk 236 38 preventing prevent VBG cord-297469-26d8o1xk 236 39 the the DT cord-297469-26d8o1xk 236 40 activation activation NN cord-297469-26d8o1xk 236 41 and and CC cord-297469-26d8o1xk 236 42 mitochondrial mitochondrial NN cord-297469-26d8o1xk 236 43 targeting targeting NN cord-297469-26d8o1xk 236 44 of of IN cord-297469-26d8o1xk 236 45 pro pro JJ cord-297469-26d8o1xk 236 46 - - JJ cord-297469-26d8o1xk 236 47 apoptotic apoptotic JJ cord-297469-26d8o1xk 236 48 Bax Bax NNP cord-297469-26d8o1xk 236 49 Lytic Lytic NNP cord-297469-26d8o1xk 236 50 Cycle Cycle NNP cord-297469-26d8o1xk 236 51 of of IN cord-297469-26d8o1xk 236 52 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 236 53 gondii gondii NN cord-297469-26d8o1xk 236 54 : : : cord-297469-26d8o1xk 236 55 15 15 CD cord-297469-26d8o1xk 236 56 Years year NNS cord-297469-26d8o1xk 236 57 Later later RB cord-297469-26d8o1xk 236 58 The the DT cord-297469-26d8o1xk 236 59 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 236 60 Centrocone Centrocone NNP cord-297469-26d8o1xk 236 61 Houses Houses NNPS cord-297469-26d8o1xk 236 62 Cell Cell NNP cord-297469-26d8o1xk 236 63 Cycle Cycle NNP cord-297469-26d8o1xk 236 64 Regulatory Regulatory NNP cord-297469-26d8o1xk 236 65 Factors Factors NNP cord-297469-26d8o1xk 236 66 Vaccination Vaccination NNP cord-297469-26d8o1xk 236 67 with with IN cord-297469-26d8o1xk 236 68 Toxoplasma toxoplasma NN cord-297469-26d8o1xk 236 69 gondii gondii NN cord-297469-26d8o1xk 236 70 SAG-1 sag-1 IN cord-297469-26d8o1xk 236 71 protein protein NN cord-297469-26d8o1xk 236 72 isprotective isprotective FW cord-297469-26d8o1xk 236 73 against against IN cord-297469-26d8o1xk 236 74 congenital congenital JJ cord-297469-26d8o1xk 236 75 toxoplasmosis toxoplasmosi NNS cord-297469-26d8o1xk 236 76 in in IN cord-297469-26d8o1xk 236 77 BALB BALB NNP cord-297469-26d8o1xk 236 78 / / SYM cord-297469-26d8o1xk 236 79 c c NN cord-297469-26d8o1xk 236 80 mice mouse NNS cord-297469-26d8o1xk 236 81 but but CC cord-297469-26d8o1xk 236 82 not not RB cord-297469-26d8o1xk 236 83 in in IN cord-297469-26d8o1xk 236 84 CBA CBA NNP cord-297469-26d8o1xk 236 85 / / SYM cord-297469-26d8o1xk 236 86 J J NNP cord-297469-26d8o1xk 236 87 mice mouse NNS cord-297469-26d8o1xk 236 88 Unique unique JJ cord-297469-26d8o1xk 236 89 secretory secretory JJ cord-297469-26d8o1xk 236 90 organelles organelle NNS cord-297469-26d8o1xk 236 91 andsource andsource NN cord-297469-26d8o1xk 236 92 of of IN cord-297469-26d8o1xk 236 93 promising promising JJ cord-297469-26d8o1xk 236 94 vaccine vaccine NN cord-297469-26d8o1xk 236 95 proteins protein NNS cord-297469-26d8o1xk 236 96 for for IN cord-297469-26d8o1xk 236 97 immunoprevention immunoprevention NN cord-297469-26d8o1xk 236 98 of of IN cord-297469-26d8o1xk 236 99 toxoplasmosis toxoplasmosis NNP cord-297469-26d8o1xk 236 100 Research Research NNP cord-297469-26d8o1xk 236 101 progress progress NN cord-297469-26d8o1xk 236 102 on on IN cord-297469-26d8o1xk 236 103 surface surface NN cord-297469-26d8o1xk 236 104 antigen antigen NN cord-297469-26d8o1xk 236 105 1 1 CD cord-297469-26d8o1xk 236 106 ( ( -LRB- cord-297469-26d8o1xk 236 107 SAG1 SAG1 NNP cord-297469-26d8o1xk 236 108 ) ) -RRB- cord-297469-26d8o1xk 236 109 of of IN cord-297469-26d8o1xk 236 110 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 236 111 gondii gondii NNP cord-297469-26d8o1xk 236 112 Targeted target VBN cord-297469-26d8o1xk 236 113 Delivery Delivery NNP cord-297469-26d8o1xk 236 114 of of IN cord-297469-26d8o1xk 236 115 Toxoplasma Toxoplasma NNP cord-297469-26d8o1xk 236 116 gondii gondii NN cord-297469-26d8o1xk 236 117 Antigens antigen NNS cord-297469-26d8o1xk 236 118 to to IN cord-297469-26d8o1xk 236 119 Dendritic Dendritic NNP cord-297469-26d8o1xk 236 120 Cells cell NNS cord-297469-26d8o1xk 237 1 Promote promote VB cord-297469-26d8o1xk 237 2 Immunogenicity Immunogenicity NNP cord-297469-26d8o1xk 237 3 and and CC cord-297469-26d8o1xk 237 4 Protective Protective NNP cord-297469-26d8o1xk 237 5 Efficiency Efficiency NNP cord-297469-26d8o1xk 237 6 against against IN cord-297469-26d8o1xk 237 7 This this DT cord-297469-26d8o1xk 237 8 article article NN cord-297469-26d8o1xk 237 9 is be VBZ cord-297469-26d8o1xk 237 10 an an DT cord-297469-26d8o1xk 237 11 open open JJ cord-297469-26d8o1xk 237 12 access access NN cord-297469-26d8o1xk 237 13 article article NN cord-297469-26d8o1xk 237 14 distributed distribute VBN cord-297469-26d8o1xk 237 15 under under IN cord-297469-26d8o1xk 237 16 the the DT cord-297469-26d8o1xk 237 17 terms term NNS cord-297469-26d8o1xk 237 18 and and CC cord-297469-26d8o1xk 237 19 conditions condition NNS cord-297469-26d8o1xk 237 20 of of IN cord-297469-26d8o1xk 237 21 the the DT cord-297469-26d8o1xk 237 22 Creative Creative NNP cord-297469-26d8o1xk 237 23 Commons Commons NNP cord-297469-26d8o1xk 237 24 Attribution Attribution NNP cord-297469-26d8o1xk 237 25 ( ( -LRB- cord-297469-26d8o1xk 237 26 CC CC NNP cord-297469-26d8o1xk 237 27 BY by IN cord-297469-26d8o1xk 237 28 ) ) -RRB- cord-297469-26d8o1xk 237 29 license license NN