id	sid	tid	token	lemma	pos
cord-304876-txaoz7oh	1	1	key	key	NN
cord-304876-txaoz7oh	1	2	:	:	:
cord-304876-txaoz7oh	2	1	cord-304876-txaoz7oh	cord-304876-txaoz7oh	NNP
cord-304876-txaoz7oh	2	2	authors	author	NNS
cord-304876-txaoz7oh	2	3	:	:	:
cord-304876-txaoz7oh	2	4	Jordan	Jordan	NNP
cord-304876-txaoz7oh	2	5	,	,	,
cord-304876-txaoz7oh	2	6	Paul	Paul	NNP
cord-304876-txaoz7oh	2	7	C	C	NNP
cord-304876-txaoz7oh	2	8	;	;	:
cord-304876-txaoz7oh	2	9	Stevens	Stevens	NNP
cord-304876-txaoz7oh	2	10	,	,	,
cord-304876-txaoz7oh	2	11	Sarah	Sarah	NNP
cord-304876-txaoz7oh	2	12	K	K	NNP
cord-304876-txaoz7oh	2	13	;	;	:
cord-304876-txaoz7oh	2	14	Deval	Deval	NNP
cord-304876-txaoz7oh	2	15	,	,	,
cord-304876-txaoz7oh	3	1	Jerome	Jerome	NNP
cord-304876-txaoz7oh	3	2	title	title	NN
cord-304876-txaoz7oh	3	3	:	:	:
cord-304876-txaoz7oh	3	4	Nucleosides	Nucleosides	NNP
cord-304876-txaoz7oh	3	5	for	for	IN
cord-304876-txaoz7oh	3	6	the	the	DT
cord-304876-txaoz7oh	3	7	treatment	treatment	NN
cord-304876-txaoz7oh	3	8	of	of	IN
cord-304876-txaoz7oh	3	9	respiratory	respiratory	JJ
cord-304876-txaoz7oh	3	10	RNA	RNA	NNP
cord-304876-txaoz7oh	3	11	virus	virus	NN
cord-304876-txaoz7oh	3	12	infections	infection	NNS
cord-304876-txaoz7oh	3	13	date	date	NN
cord-304876-txaoz7oh	3	14	:	:	:
cord-304876-txaoz7oh	3	15	2018	2018	CD
cord-304876-txaoz7oh	3	16	-	-	HYPH
cord-304876-txaoz7oh	3	17	03	03	CD
cord-304876-txaoz7oh	3	18	-	-	SYM
cord-304876-txaoz7oh	3	19	21	21	CD
cord-304876-txaoz7oh	3	20	journal	journal	NN
cord-304876-txaoz7oh	3	21	:	:	:
cord-304876-txaoz7oh	4	1	Antivir	Antivir	NNP
cord-304876-txaoz7oh	4	2	Chem	Chem	NNP
cord-304876-txaoz7oh	4	3	Chemother	Chemother	NNP
cord-304876-txaoz7oh	4	4	DOI	DOI	NNP
cord-304876-txaoz7oh	4	5	:	:	:
cord-304876-txaoz7oh	5	1	10.1177/2040206618764483	10.1177/2040206618764483	CD
cord-304876-txaoz7oh	5	2	sha	sha	NNP
cord-304876-txaoz7oh	5	3	:	:	:
cord-304876-txaoz7oh	6	1	097e78073b154805e74de8245008ee3f91c24af2	097e78073b154805e74de8245008ee3f91c24af2	NNP
cord-304876-txaoz7oh	6	2	doc_id	doc_id	CD
cord-304876-txaoz7oh	7	1	:	:	:
cord-304876-txaoz7oh	7	2	304876	304876	CD
cord-304876-txaoz7oh	7	3	cord_uid	cord_uid	NN
cord-304876-txaoz7oh	7	4	:	:	:
cord-304876-txaoz7oh	8	1	txaoz7oh	txaoz7oh	NNP
cord-304876-txaoz7oh	9	1	Influenza	influenza	NN
cord-304876-txaoz7oh	9	2	virus	virus	NN
cord-304876-txaoz7oh	9	3	,	,	,
cord-304876-txaoz7oh	9	4	respiratory	respiratory	JJ
cord-304876-txaoz7oh	9	5	syncytial	syncytial	JJ
cord-304876-txaoz7oh	9	6	virus	virus	NN
cord-304876-txaoz7oh	9	7	,	,	,
cord-304876-txaoz7oh	9	8	human	human	JJ
cord-304876-txaoz7oh	9	9	metapneumovirus	metapneumovirus	NNP
cord-304876-txaoz7oh	9	10	,	,	,
cord-304876-txaoz7oh	9	11	parainfluenza	parainfluenza	NNP
cord-304876-txaoz7oh	9	12	virus	virus	NNP
cord-304876-txaoz7oh	9	13	,	,	,
cord-304876-txaoz7oh	9	14	coronaviruses	coronaviruse	NNS
cord-304876-txaoz7oh	9	15	,	,	,
cord-304876-txaoz7oh	9	16	and	and	CC
cord-304876-txaoz7oh	9	17	rhinoviruses	rhinovirus	NNS
cord-304876-txaoz7oh	9	18	are	be	VBP
cord-304876-txaoz7oh	9	19	among	among	IN
cord-304876-txaoz7oh	9	20	the	the	DT
cord-304876-txaoz7oh	9	21	most	most	RBS
cord-304876-txaoz7oh	9	22	common	common	JJ
cord-304876-txaoz7oh	9	23	viruses	virus	NNS
cord-304876-txaoz7oh	9	24	causing	cause	VBG
cord-304876-txaoz7oh	9	25	mild	mild	JJ
cord-304876-txaoz7oh	9	26	seasonal	seasonal	JJ
cord-304876-txaoz7oh	9	27	colds	cold	NNS
cord-304876-txaoz7oh	9	28	.	.	.
cord-304876-txaoz7oh	10	1	These	these	DT
cord-304876-txaoz7oh	10	2	RNA	RNA	NNP
cord-304876-txaoz7oh	10	3	viruses	virus	NNS
cord-304876-txaoz7oh	10	4	can	can	MD
cord-304876-txaoz7oh	10	5	also	also	RB
cord-304876-txaoz7oh	10	6	cause	cause	VB
cord-304876-txaoz7oh	10	7	lower	low	JJR
cord-304876-txaoz7oh	10	8	respiratory	respiratory	JJ
cord-304876-txaoz7oh	10	9	tract	tract	NN
cord-304876-txaoz7oh	10	10	infections	infection	NNS
cord-304876-txaoz7oh	10	11	leading	lead	VBG
cord-304876-txaoz7oh	10	12	to	to	IN
cord-304876-txaoz7oh	10	13	bronchiolitis	bronchiolitis	NN
cord-304876-txaoz7oh	10	14	and	and	CC
cord-304876-txaoz7oh	10	15	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	10	16	.	.	.
cord-304876-txaoz7oh	11	1	Young	young	JJ
cord-304876-txaoz7oh	11	2	children	child	NNS
cord-304876-txaoz7oh	11	3	,	,	,
cord-304876-txaoz7oh	11	4	the	the	DT
cord-304876-txaoz7oh	11	5	elderly	elderly	JJ
cord-304876-txaoz7oh	11	6	,	,	,
cord-304876-txaoz7oh	11	7	and	and	CC
cord-304876-txaoz7oh	11	8	patients	patient	NNS
cord-304876-txaoz7oh	11	9	with	with	IN
cord-304876-txaoz7oh	11	10	compromised	compromised	JJ
cord-304876-txaoz7oh	11	11	cardiac	cardiac	JJ
cord-304876-txaoz7oh	11	12	,	,	,
cord-304876-txaoz7oh	11	13	pulmonary	pulmonary	JJ
cord-304876-txaoz7oh	11	14	,	,	,
cord-304876-txaoz7oh	11	15	or	or	CC
cord-304876-txaoz7oh	11	16	immune	immune	JJ
cord-304876-txaoz7oh	11	17	systems	system	NNS
cord-304876-txaoz7oh	11	18	are	be	VBP
cord-304876-txaoz7oh	11	19	at	at	IN
cord-304876-txaoz7oh	11	20	greatest	great	JJS
cord-304876-txaoz7oh	11	21	risk	risk	NN
cord-304876-txaoz7oh	11	22	for	for	IN
cord-304876-txaoz7oh	11	23	serious	serious	JJ
cord-304876-txaoz7oh	11	24	disease	disease	NN
cord-304876-txaoz7oh	11	25	associated	associate	VBN
cord-304876-txaoz7oh	11	26	with	with	IN
cord-304876-txaoz7oh	11	27	these	these	DT
cord-304876-txaoz7oh	11	28	RNA	RNA	NNP
cord-304876-txaoz7oh	11	29	virus	virus	NN
cord-304876-txaoz7oh	11	30	respiratory	respiratory	JJ
cord-304876-txaoz7oh	11	31	infections	infection	NNS
cord-304876-txaoz7oh	11	32	.	.	.
cord-304876-txaoz7oh	12	1	In	in	IN
cord-304876-txaoz7oh	12	2	addition	addition	NN
cord-304876-txaoz7oh	12	3	,	,	,
cord-304876-txaoz7oh	12	4	swine	swine	NN
cord-304876-txaoz7oh	12	5	and	and	CC
cord-304876-txaoz7oh	12	6	avian	avian	JJ
cord-304876-txaoz7oh	12	7	influenza	influenza	NN
cord-304876-txaoz7oh	12	8	viruses	virus	NNS
cord-304876-txaoz7oh	12	9	,	,	,
cord-304876-txaoz7oh	12	10	together	together	RB
cord-304876-txaoz7oh	12	11	with	with	IN
cord-304876-txaoz7oh	12	12	severe	severe	JJ
cord-304876-txaoz7oh	12	13	acute	acute	JJ
cord-304876-txaoz7oh	12	14	respiratory	respiratory	JJ
cord-304876-txaoz7oh	12	15	syndrome	syndrome	NN
cord-304876-txaoz7oh	12	16	-	-	HYPH
cord-304876-txaoz7oh	12	17	associated	associate	VBN
cord-304876-txaoz7oh	12	18	and	and	CC
cord-304876-txaoz7oh	12	19	Middle	middle	JJ
cord-304876-txaoz7oh	12	20	Eastern	eastern	JJ
cord-304876-txaoz7oh	12	21	respiratory	respiratory	JJ
cord-304876-txaoz7oh	12	22	syndrome	syndrome	NN
cord-304876-txaoz7oh	12	23	coronaviruses	coronaviruse	NNS
cord-304876-txaoz7oh	12	24	,	,	,
cord-304876-txaoz7oh	12	25	represent	represent	VBP
cord-304876-txaoz7oh	12	26	significant	significant	JJ
cord-304876-txaoz7oh	12	27	pandemic	pandemic	NN
cord-304876-txaoz7oh	12	28	threats	threat	NNS
cord-304876-txaoz7oh	12	29	to	to	IN
cord-304876-txaoz7oh	12	30	the	the	DT
cord-304876-txaoz7oh	12	31	general	general	JJ
cord-304876-txaoz7oh	12	32	population	population	NN
cord-304876-txaoz7oh	12	33	.	.	.
cord-304876-txaoz7oh	13	1	In	in	IN
cord-304876-txaoz7oh	13	2	this	this	DT
cord-304876-txaoz7oh	13	3	review	review	NN
cord-304876-txaoz7oh	13	4	,	,	,
cord-304876-txaoz7oh	13	5	we	-PRON-	PRP
cord-304876-txaoz7oh	13	6	describe	describe	VBP
cord-304876-txaoz7oh	13	7	the	the	DT
cord-304876-txaoz7oh	13	8	current	current	JJ
cord-304876-txaoz7oh	13	9	medical	medical	JJ
cord-304876-txaoz7oh	13	10	need	need	NN
cord-304876-txaoz7oh	13	11	resulting	result	VBG
cord-304876-txaoz7oh	13	12	from	from	IN
cord-304876-txaoz7oh	13	13	respiratory	respiratory	JJ
cord-304876-txaoz7oh	13	14	infections	infection	NNS
cord-304876-txaoz7oh	13	15	caused	cause	VBN
cord-304876-txaoz7oh	13	16	by	by	IN
cord-304876-txaoz7oh	13	17	RNA	RNA	NNP
cord-304876-txaoz7oh	13	18	viruses	virus	NNS
cord-304876-txaoz7oh	13	19	,	,	,
cord-304876-txaoz7oh	13	20	which	which	WDT
cord-304876-txaoz7oh	13	21	justifies	justify	VBZ
cord-304876-txaoz7oh	13	22	drug	drug	NN
cord-304876-txaoz7oh	13	23	discovery	discovery	NN
cord-304876-txaoz7oh	13	24	efforts	effort	NNS
cord-304876-txaoz7oh	13	25	to	to	TO
cord-304876-txaoz7oh	13	26	identify	identify	VB
cord-304876-txaoz7oh	13	27	new	new	JJ
cord-304876-txaoz7oh	13	28	therapeutic	therapeutic	JJ
cord-304876-txaoz7oh	13	29	agents	agent	NNS
cord-304876-txaoz7oh	13	30	.	.	.
cord-304876-txaoz7oh	14	1	The	the	DT
cord-304876-txaoz7oh	14	2	RNA	RNA	NNP
cord-304876-txaoz7oh	14	3	polymerase	polymerase	NN
cord-304876-txaoz7oh	14	4	of	of	IN
cord-304876-txaoz7oh	14	5	respiratory	respiratory	JJ
cord-304876-txaoz7oh	14	6	viruses	virus	NNS
cord-304876-txaoz7oh	14	7	represents	represent	VBZ
cord-304876-txaoz7oh	14	8	an	an	DT
cord-304876-txaoz7oh	14	9	attractive	attractive	JJ
cord-304876-txaoz7oh	14	10	target	target	NN
cord-304876-txaoz7oh	14	11	for	for	IN
cord-304876-txaoz7oh	14	12	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	14	13	and	and	CC
cord-304876-txaoz7oh	14	14	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	14	15	analogs	analog	NNS
cord-304876-txaoz7oh	14	16	acting	act	VBG
cord-304876-txaoz7oh	14	17	as	as	IN
cord-304876-txaoz7oh	14	18	inhibitors	inhibitor	NNS
cord-304876-txaoz7oh	14	19	of	of	IN
cord-304876-txaoz7oh	14	20	RNA	RNA	NNP
cord-304876-txaoz7oh	14	21	chain	chain	NN
cord-304876-txaoz7oh	14	22	synthesis	synthesis	NN
cord-304876-txaoz7oh	14	23	.	.	.
cord-304876-txaoz7oh	15	1	Here	here	RB
cord-304876-txaoz7oh	15	2	,	,	,
cord-304876-txaoz7oh	15	3	we	-PRON-	PRP
cord-304876-txaoz7oh	15	4	present	present	VBP
cord-304876-txaoz7oh	15	5	the	the	DT
cord-304876-txaoz7oh	15	6	molecular	molecular	JJ
cord-304876-txaoz7oh	15	7	,	,	,
cord-304876-txaoz7oh	15	8	biochemical	biochemical	JJ
cord-304876-txaoz7oh	15	9	,	,	,
cord-304876-txaoz7oh	15	10	and	and	CC
cord-304876-txaoz7oh	15	11	structural	structural	JJ
cord-304876-txaoz7oh	15	12	fundamentals	fundamental	NNS
cord-304876-txaoz7oh	15	13	of	of	IN
cord-304876-txaoz7oh	15	14	the	the	DT
cord-304876-txaoz7oh	15	15	polymerase	polymerase	NN
cord-304876-txaoz7oh	15	16	of	of	IN
cord-304876-txaoz7oh	15	17	the	the	DT
cord-304876-txaoz7oh	15	18	four	four	CD
cord-304876-txaoz7oh	15	19	major	major	JJ
cord-304876-txaoz7oh	15	20	families	family	NNS
cord-304876-txaoz7oh	15	21	of	of	IN
cord-304876-txaoz7oh	15	22	RNA	RNA	NNP
cord-304876-txaoz7oh	15	23	respiratory	respiratory	JJ
cord-304876-txaoz7oh	15	24	viruses	virus	NNS
cord-304876-txaoz7oh	15	25	:	:	:
cord-304876-txaoz7oh	16	1	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-304876-txaoz7oh	16	2	,	,	,
cord-304876-txaoz7oh	16	3	Pneumoviridae	Pneumoviridae	NNP
cord-304876-txaoz7oh	16	4	/	/	SYM
cord-304876-txaoz7oh	16	5	Paramyxoviridae	Paramyxoviridae	NNP
cord-304876-txaoz7oh	16	6	,	,	,
cord-304876-txaoz7oh	16	7	Coronaviridae	Coronaviridae	NNP
cord-304876-txaoz7oh	16	8	,	,	,
cord-304876-txaoz7oh	16	9	and	and	CC
cord-304876-txaoz7oh	16	10	Picornaviridae	Picornaviridae	NNP
cord-304876-txaoz7oh	16	11	.	.	.
cord-304876-txaoz7oh	17	1	We	-PRON-	PRP
cord-304876-txaoz7oh	17	2	summarize	summarize	VBP
cord-304876-txaoz7oh	17	3	past	past	JJ
cord-304876-txaoz7oh	17	4	and	and	CC
cord-304876-txaoz7oh	17	5	current	current	JJ
cord-304876-txaoz7oh	17	6	efforts	effort	NNS
cord-304876-txaoz7oh	17	7	to	to	TO
cord-304876-txaoz7oh	17	8	develop	develop	VB
cord-304876-txaoz7oh	17	9	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	17	10	and	and	CC
cord-304876-txaoz7oh	17	11	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	17	12	analogs	analog	NNS
cord-304876-txaoz7oh	17	13	as	as	IN
cord-304876-txaoz7oh	17	14	antiviral	antiviral	JJ
cord-304876-txaoz7oh	17	15	agents	agent	NNS
cord-304876-txaoz7oh	17	16	against	against	IN
cord-304876-txaoz7oh	17	17	respiratory	respiratory	JJ
cord-304876-txaoz7oh	17	18	virus	virus	NN
cord-304876-txaoz7oh	17	19	infections	infection	NNS
cord-304876-txaoz7oh	17	20	.	.	.
cord-304876-txaoz7oh	18	1	This	this	DT
cord-304876-txaoz7oh	18	2	includes	include	VBZ
cord-304876-txaoz7oh	18	3	molecules	molecule	NNS
cord-304876-txaoz7oh	18	4	with	with	IN
cord-304876-txaoz7oh	18	5	very	very	RB
cord-304876-txaoz7oh	18	6	broad	broad	JJ
cord-304876-txaoz7oh	18	7	antiviral	antiviral	JJ
cord-304876-txaoz7oh	18	8	spectrum	spectrum	NN
cord-304876-txaoz7oh	18	9	such	such	JJ
cord-304876-txaoz7oh	18	10	as	as	IN
cord-304876-txaoz7oh	18	11	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	18	12	and	and	CC
cord-304876-txaoz7oh	18	13	T-705	T-705	NNS
cord-304876-txaoz7oh	18	14	(	(	-LRB-
cord-304876-txaoz7oh	18	15	favipiravir	favipiravir	NNP
cord-304876-txaoz7oh	18	16	)	)	-RRB-
cord-304876-txaoz7oh	18	17	,	,	,
cord-304876-txaoz7oh	18	18	and	and	CC
cord-304876-txaoz7oh	18	19	others	other	NNS
cord-304876-txaoz7oh	18	20	targeting	target	VBG
cord-304876-txaoz7oh	18	21	more	more	JJR
cord-304876-txaoz7oh	18	22	specifically	specifically	RB
cord-304876-txaoz7oh	18	23	one	one	CD
cord-304876-txaoz7oh	18	24	or	or	CC
cord-304876-txaoz7oh	18	25	a	a	DT
cord-304876-txaoz7oh	18	26	few	few	JJ
cord-304876-txaoz7oh	18	27	virus	virus	NN
cord-304876-txaoz7oh	18	28	families	family	NNS
cord-304876-txaoz7oh	18	29	.	.	.
cord-304876-txaoz7oh	19	1	Recent	recent	JJ
cord-304876-txaoz7oh	19	2	advances	advance	NNS
cord-304876-txaoz7oh	19	3	in	in	IN
cord-304876-txaoz7oh	19	4	our	-PRON-	PRP$
cord-304876-txaoz7oh	19	5	understanding	understanding	NN
cord-304876-txaoz7oh	19	6	of	of	IN
cord-304876-txaoz7oh	19	7	the	the	DT
cord-304876-txaoz7oh	19	8	structure(s	structure(s	NN
cord-304876-txaoz7oh	19	9	)	)	-RRB-
cord-304876-txaoz7oh	19	10	and	and	CC
cord-304876-txaoz7oh	19	11	function(s	function(s	NNP
cord-304876-txaoz7oh	19	12	)	)	-RRB-
cord-304876-txaoz7oh	19	13	of	of	IN
cord-304876-txaoz7oh	19	14	respiratory	respiratory	JJ
cord-304876-txaoz7oh	19	15	virus	virus	NN
cord-304876-txaoz7oh	19	16	polymerases	polymerase	NNS
cord-304876-txaoz7oh	19	17	will	will	MD
cord-304876-txaoz7oh	19	18	likely	likely	RB
cord-304876-txaoz7oh	19	19	support	support	VB
cord-304876-txaoz7oh	19	20	the	the	DT
cord-304876-txaoz7oh	19	21	discovery	discovery	NN
cord-304876-txaoz7oh	19	22	and	and	CC
cord-304876-txaoz7oh	19	23	development	development	NN
cord-304876-txaoz7oh	19	24	of	of	IN
cord-304876-txaoz7oh	19	25	novel	novel	JJ
cord-304876-txaoz7oh	19	26	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	19	27	analogs	analog	NNS
cord-304876-txaoz7oh	19	28	.	.	.
cord-304876-txaoz7oh	20	1	Respiratory	respiratory	JJ
cord-304876-txaoz7oh	20	2	viral	viral	JJ
cord-304876-txaoz7oh	20	3	infections	infection	NNS
cord-304876-txaoz7oh	20	4	are	be	VBP
cord-304876-txaoz7oh	20	5	a	a	DT
cord-304876-txaoz7oh	20	6	global	global	JJ
cord-304876-txaoz7oh	20	7	health	health	NN
cord-304876-txaoz7oh	20	8	concern	concern	NN
cord-304876-txaoz7oh	20	9	caused	cause	VBN
cord-304876-txaoz7oh	20	10	by	by	IN
cord-304876-txaoz7oh	20	11	dozens	dozen	NNS
cord-304876-txaoz7oh	20	12	of	of	IN
cord-304876-txaoz7oh	20	13	different	different	JJ
cord-304876-txaoz7oh	20	14	types	type	NNS
cord-304876-txaoz7oh	20	15	of	of	IN
cord-304876-txaoz7oh	20	16	viruses	virus	NNS
cord-304876-txaoz7oh	20	17	.	.	.
cord-304876-txaoz7oh	21	1	The	the	DT
cord-304876-txaoz7oh	21	2	respiratory	respiratory	JJ
cord-304876-txaoz7oh	21	3	diseases	disease	NNS
cord-304876-txaoz7oh	21	4	resulting	result	VBG
cord-304876-txaoz7oh	21	5	from	from	IN
cord-304876-txaoz7oh	21	6	these	these	DT
cord-304876-txaoz7oh	21	7	viral	viral	JJ
cord-304876-txaoz7oh	21	8	infections	infection	NNS
cord-304876-txaoz7oh	21	9	represent	represent	VBP
cord-304876-txaoz7oh	21	10	one	one	CD
cord-304876-txaoz7oh	21	11	of	of	IN
cord-304876-txaoz7oh	21	12	the	the	DT
cord-304876-txaoz7oh	21	13	main	main	JJ
cord-304876-txaoz7oh	21	14	causes	cause	NNS
cord-304876-txaoz7oh	21	15	of	of	IN
cord-304876-txaoz7oh	21	16	death	death	NN
cord-304876-txaoz7oh	21	17	in	in	IN
cord-304876-txaoz7oh	21	18	developing	develop	VBG
cord-304876-txaoz7oh	21	19	countries	country	NNS
cord-304876-txaoz7oh	21	20	.	.	.
cord-304876-txaoz7oh	22	1	1	1	LS
cord-304876-txaoz7oh	23	1	A	a	DT
cord-304876-txaoz7oh	23	2	more	more	RBR
cord-304876-txaoz7oh	23	3	thorough	thorough	JJ
cord-304876-txaoz7oh	23	4	understanding	understanding	NN
cord-304876-txaoz7oh	23	5	of	of	IN
cord-304876-txaoz7oh	23	6	respiratory	respiratory	JJ
cord-304876-txaoz7oh	23	7	viruses	virus	NNS
cord-304876-txaoz7oh	23	8	,	,	,
cord-304876-txaoz7oh	23	9	their	-PRON-	PRP$
cord-304876-txaoz7oh	23	10	epidemiology	epidemiology	NN
cord-304876-txaoz7oh	23	11	,	,	,
cord-304876-txaoz7oh	23	12	as	as	RB
cord-304876-txaoz7oh	23	13	well	well	RB
cord-304876-txaoz7oh	23	14	as	as	IN
cord-304876-txaoz7oh	23	15	medical	medical	JJ
cord-304876-txaoz7oh	23	16	impact	impact	NN
cord-304876-txaoz7oh	23	17	on	on	IN
cord-304876-txaoz7oh	23	18	the	the	DT
cord-304876-txaoz7oh	23	19	communities	community	NNS
cord-304876-txaoz7oh	23	20	they	-PRON-	PRP
cord-304876-txaoz7oh	23	21	affect	affect	VBP
cord-304876-txaoz7oh	23	22	will	will	MD
cord-304876-txaoz7oh	23	23	delineate	delineate	VB
cord-304876-txaoz7oh	23	24	the	the	DT
cord-304876-txaoz7oh	23	25	path	path	NN
cord-304876-txaoz7oh	23	26	toward	toward	IN
cord-304876-txaoz7oh	23	27	eventual	eventual	JJ
cord-304876-txaoz7oh	23	28	treatments	treatment	NNS
cord-304876-txaoz7oh	23	29	and	and	CC
cord-304876-txaoz7oh	23	30	future	future	JJ
cord-304876-txaoz7oh	23	31	abatement	abatement	NN
cord-304876-txaoz7oh	23	32	of	of	IN
cord-304876-txaoz7oh	23	33	the	the	DT
cord-304876-txaoz7oh	23	34	illnesses	illness	NNS
cord-304876-txaoz7oh	23	35	.	.	.
cord-304876-txaoz7oh	24	1	While	while	IN
cord-304876-txaoz7oh	24	2	symptoms	symptom	NNS
cord-304876-txaoz7oh	24	3	of	of	IN
cord-304876-txaoz7oh	24	4	many	many	JJ
cord-304876-txaoz7oh	24	5	respiratory	respiratory	JJ
cord-304876-txaoz7oh	24	6	viruses	virus	NNS
cord-304876-txaoz7oh	24	7	are	be	VBP
cord-304876-txaoz7oh	24	8	similar	similar	JJ
cord-304876-txaoz7oh	24	9	,	,	,
cord-304876-txaoz7oh	24	10	the	the	DT
cord-304876-txaoz7oh	24	11	viruses	virus	NNS
cord-304876-txaoz7oh	24	12	themselves	-PRON-	PRP
cord-304876-txaoz7oh	24	13	are	be	VBP
cord-304876-txaoz7oh	24	14	characteristically	characteristically	RB
cord-304876-txaoz7oh	24	15	unique	unique	JJ
cord-304876-txaoz7oh	24	16	.	.	.
cord-304876-txaoz7oh	25	1	Categorically	categorically	RB
cord-304876-txaoz7oh	25	2	,	,	,
cord-304876-txaoz7oh	25	3	viruses	virus	NNS
cord-304876-txaoz7oh	25	4	are	be	VBP
cord-304876-txaoz7oh	25	5	grouped	group	VBN
cord-304876-txaoz7oh	25	6	based	base	VBN
cord-304876-txaoz7oh	25	7	on	on	IN
cord-304876-txaoz7oh	25	8	similarities	similarity	NNS
cord-304876-txaoz7oh	25	9	such	such	JJ
cord-304876-txaoz7oh	25	10	as	as	IN
cord-304876-txaoz7oh	25	11	the	the	DT
cord-304876-txaoz7oh	25	12	nature	nature	NN
cord-304876-txaoz7oh	25	13	of	of	IN
cord-304876-txaoz7oh	25	14	their	-PRON-	PRP$
cord-304876-txaoz7oh	25	15	nucleic	nucleic	JJ
cord-304876-txaoz7oh	25	16	acid	acid	NN
cord-304876-txaoz7oh	25	17	genome	genome	NN
cord-304876-txaoz7oh	25	18	,	,	,
cord-304876-txaoz7oh	25	19	envelope	envelope	NN
cord-304876-txaoz7oh	25	20	presence	presence	NN
cord-304876-txaoz7oh	25	21	,	,	,
cord-304876-txaoz7oh	25	22	overall	overall	JJ
cord-304876-txaoz7oh	25	23	size	size	NN
cord-304876-txaoz7oh	25	24	,	,	,
cord-304876-txaoz7oh	25	25	and	and	CC
cord-304876-txaoz7oh	25	26	even	even	RB
cord-304876-txaoz7oh	25	27	capsid	capsid	NN
cord-304876-txaoz7oh	25	28	uniformity	uniformity	NN
cord-304876-txaoz7oh	25	29	.	.	.
cord-304876-txaoz7oh	26	1	2	2	LS
cord-304876-txaoz7oh	27	1	This	this	DT
cord-304876-txaoz7oh	27	2	review	review	NN
cord-304876-txaoz7oh	27	3	focuses	focus	VBZ
cord-304876-txaoz7oh	27	4	on	on	IN
cord-304876-txaoz7oh	27	5	the	the	DT
cord-304876-txaoz7oh	27	6	following	follow	VBG
cord-304876-txaoz7oh	27	7	families	family	NNS
cord-304876-txaoz7oh	27	8	of	of	IN
cord-304876-txaoz7oh	27	9	RNA	RNA	NNP
cord-304876-txaoz7oh	27	10	viruses	virus	NNS
cord-304876-txaoz7oh	27	11	:	:	:
cord-304876-txaoz7oh	27	12	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-304876-txaoz7oh	27	13	,	,	,
cord-304876-txaoz7oh	27	14	Paramyxoviridae	Paramyxoviridae	NNP
cord-304876-txaoz7oh	27	15	and	and	CC
cord-304876-txaoz7oh	27	16	Pneumoviridae	Pneumoviridae	NNP
cord-304876-txaoz7oh	27	17	,	,	,
cord-304876-txaoz7oh	27	18	Picornaviridae	Picornaviridae	NNP
cord-304876-txaoz7oh	27	19	,	,	,
cord-304876-txaoz7oh	27	20	and	and	CC
cord-304876-txaoz7oh	27	21	Coronaviridae	Coronaviridae	NNP
cord-304876-txaoz7oh	27	22	.	.	.
cord-304876-txaoz7oh	28	1	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-304876-txaoz7oh	28	2	comprise	comprise	VBP
cord-304876-txaoz7oh	29	1	negative	negative	JJ
cord-304876-txaoz7oh	29	2	(	(	-LRB-
cord-304876-txaoz7oh	29	3	-	-	:
cord-304876-txaoz7oh	29	4	)	)	-RRB-
cord-304876-txaoz7oh	29	5	sense	sense	NN
cord-304876-txaoz7oh	29	6	singlestranded	singlestranded	NNP
cord-304876-txaoz7oh	29	7	(	(	-LRB-
cord-304876-txaoz7oh	29	8	ss	ss	NNP
cord-304876-txaoz7oh	29	9	)	)	-RRB-
cord-304876-txaoz7oh	29	10	RNA	RNA	NNP
cord-304876-txaoz7oh	29	11	viruses	virus	NNS
cord-304876-txaoz7oh	29	12	that	that	WDT
cord-304876-txaoz7oh	29	13	are	be	VBP
cord-304876-txaoz7oh	29	14	segmented	segmented	JJ
cord-304876-txaoz7oh	29	15	,	,	,
cord-304876-txaoz7oh	29	16	enveloped	envelop	VBN
cord-304876-txaoz7oh	29	17	,	,	,
cord-304876-txaoz7oh	29	18	and	and	CC
cord-304876-txaoz7oh	29	19	includes	include	VBZ
cord-304876-txaoz7oh	29	20	the	the	DT
cord-304876-txaoz7oh	29	21	influenza	influenza	NN
cord-304876-txaoz7oh	29	22	viruses	virus	NNS
cord-304876-txaoz7oh	29	23	(	(	-LRB-
cord-304876-txaoz7oh	29	24	see	see	VB
cord-304876-txaoz7oh	29	25	Table	table	NN
cord-304876-txaoz7oh	29	26	1	1	CD
cord-304876-txaoz7oh	29	27	)	)	-RRB-
cord-304876-txaoz7oh	29	28	.	.	.
cord-304876-txaoz7oh	30	1	Paramyxoviridae	Paramyxoviridae	NNP
cord-304876-txaoz7oh	30	2	and	and	CC
cord-304876-txaoz7oh	30	3	Pneumoviridae	Pneumoviridae	NNP
cord-304876-txaoz7oh	30	4	are	be	VBP
cord-304876-txaoz7oh	30	5	also	also	RB
cord-304876-txaoz7oh	30	6	(	(	-LRB-
cord-304876-txaoz7oh	30	7	-)ssRNA	-)ssRNA	NNS
cord-304876-txaoz7oh	30	8	viruses	virus	NNS
cord-304876-txaoz7oh	30	9	,	,	,
cord-304876-txaoz7oh	30	10	but	but	CC
cord-304876-txaoz7oh	30	11	are	be	VBP
cord-304876-txaoz7oh	30	12	non	non	JJ
cord-304876-txaoz7oh	30	13	-	-	JJ
cord-304876-txaoz7oh	30	14	segmented	segmented	JJ
cord-304876-txaoz7oh	30	15	and	and	CC
cord-304876-txaoz7oh	30	16	enveloped	envelop	VBN
cord-304876-txaoz7oh	30	17	,	,	,
cord-304876-txaoz7oh	30	18	and	and	CC
cord-304876-txaoz7oh	30	19	include	include	VBP
cord-304876-txaoz7oh	30	20	parainfluenza	parainfluenza	NNP
cord-304876-txaoz7oh	30	21	virus	virus	NNP
cord-304876-txaoz7oh	30	22	(	(	-LRB-
cord-304876-txaoz7oh	30	23	PIV	PIV	NNP
cord-304876-txaoz7oh	30	24	)	)	-RRB-
cord-304876-txaoz7oh	30	25	,	,	,
cord-304876-txaoz7oh	30	26	human	human	JJ
cord-304876-txaoz7oh	30	27	respiratory	respiratory	JJ
cord-304876-txaoz7oh	30	28	syncytial	syncytial	JJ
cord-304876-txaoz7oh	30	29	virus	virus	NN
cord-304876-txaoz7oh	30	30	(	(	-LRB-
cord-304876-txaoz7oh	30	31	RSV	RSV	NNP
cord-304876-txaoz7oh	30	32	)	)	-RRB-
cord-304876-txaoz7oh	30	33	,	,	,
cord-304876-txaoz7oh	30	34	and	and	CC
cord-304876-txaoz7oh	30	35	human	human	JJ
cord-304876-txaoz7oh	30	36	metapneumovirus	metapneumovirus	NNP
cord-304876-txaoz7oh	30	37	(	(	-LRB-
cord-304876-txaoz7oh	30	38	HMPV	HMPV	NNP
cord-304876-txaoz7oh	30	39	)	)	-RRB-
cord-304876-txaoz7oh	30	40	.	.	.
cord-304876-txaoz7oh	31	1	The	the	DT
cord-304876-txaoz7oh	31	2	Picornaviridae	Picornaviridae	NNP
cord-304876-txaoz7oh	31	3	family	family	NN
cord-304876-txaoz7oh	31	4	,	,	,
cord-304876-txaoz7oh	31	5	which	which	WDT
cord-304876-txaoz7oh	31	6	contains	contain	VBZ
cord-304876-txaoz7oh	31	7	positive	positive	JJ
cord-304876-txaoz7oh	31	8	(	(	-LRB-
cord-304876-txaoz7oh	31	9	þ)ssRNA	þ)ssrna	NN
cord-304876-txaoz7oh	31	10	viruses	virus	NNS
cord-304876-txaoz7oh	31	11	are	be	VBP
cord-304876-txaoz7oh	31	12	non	non	JJ
cord-304876-txaoz7oh	31	13	-	-	JJ
cord-304876-txaoz7oh	31	14	enveloped	enveloped	JJ
cord-304876-txaoz7oh	31	15	;	;	:
cord-304876-txaoz7oh	31	16	the	the	DT
cord-304876-txaoz7oh	31	17	key	key	JJ
cord-304876-txaoz7oh	31	18	members	member	NNS
cord-304876-txaoz7oh	31	19	include	include	VBP
cord-304876-txaoz7oh	31	20	the	the	DT
cord-304876-txaoz7oh	31	21	rhinoviruses	rhinovirus	NNS
cord-304876-txaoz7oh	31	22	and	and	CC
cord-304876-txaoz7oh	31	23	enteroviruses	enterovirus	NNS
cord-304876-txaoz7oh	31	24	.	.	.
cord-304876-txaoz7oh	32	1	Lastly	lastly	RB
cord-304876-txaoz7oh	32	2	,	,	,
cord-304876-txaoz7oh	32	3	the	the	DT
cord-304876-txaoz7oh	32	4	Coronaviridae	Coronaviridae	NNP
cord-304876-txaoz7oh	32	5	are	be	VBP
cord-304876-txaoz7oh	32	6	(	(	-LRB-
cord-304876-txaoz7oh	32	7	þ)ssRNA	þ)ssrna	NN
cord-304876-txaoz7oh	32	8	enveloped	envelop	VBD
cord-304876-txaoz7oh	32	9	viruses	virus	NNS
cord-304876-txaoz7oh	32	10	,	,	,
cord-304876-txaoz7oh	32	11	which	which	WDT
cord-304876-txaoz7oh	32	12	include	include	VBP
cord-304876-txaoz7oh	32	13	,	,	,
cord-304876-txaoz7oh	32	14	chiefly	chiefly	RB
cord-304876-txaoz7oh	32	15	,	,	,
cord-304876-txaoz7oh	32	16	human	human	JJ
cord-304876-txaoz7oh	32	17	coronavirus	coronavirus	NN
cord-304876-txaoz7oh	32	18	(	(	-LRB-
cord-304876-txaoz7oh	32	19	HCoV	HCoV	NNP
cord-304876-txaoz7oh	32	20	)	)	-RRB-
cord-304876-txaoz7oh	32	21	,	,	,
cord-304876-txaoz7oh	32	22	and	and	CC
cord-304876-txaoz7oh	32	23	severe	severe	JJ
cord-304876-txaoz7oh	32	24	acute	acute	JJ
cord-304876-txaoz7oh	32	25	respiratory	respiratory	JJ
cord-304876-txaoz7oh	32	26	syndrome	syndrome	NN
cord-304876-txaoz7oh	32	27	(	(	-LRB-
cord-304876-txaoz7oh	32	28	SARS)-associated	SARS)-associated	NNP
cord-304876-txaoz7oh	32	29	and	and	CC
cord-304876-txaoz7oh	32	30	Middle	middle	JJ
cord-304876-txaoz7oh	32	31	Eastern	eastern	JJ
cord-304876-txaoz7oh	32	32	respiratory	respiratory	JJ
cord-304876-txaoz7oh	32	33	syndrome	syndrome	NN
cord-304876-txaoz7oh	32	34	(	(	-LRB-
cord-304876-txaoz7oh	32	35	MERS	MERS	NNP
cord-304876-txaoz7oh	32	36	)	)	-RRB-
cord-304876-txaoz7oh	33	1	CoV.	CoV.	NNP
cord-304876-txaoz7oh	34	1	3	3	CD
cord-304876-txaoz7oh	34	2	Young	young	JJ
cord-304876-txaoz7oh	34	3	children	child	NNS
cord-304876-txaoz7oh	34	4	,	,	,
cord-304876-txaoz7oh	34	5	the	the	DT
cord-304876-txaoz7oh	34	6	elderly	elderly	JJ
cord-304876-txaoz7oh	34	7	,	,	,
cord-304876-txaoz7oh	34	8	and	and	CC
cord-304876-txaoz7oh	34	9	patients	patient	NNS
cord-304876-txaoz7oh	34	10	with	with	IN
cord-304876-txaoz7oh	34	11	compromised	compromised	JJ
cord-304876-txaoz7oh	34	12	cardiac	cardiac	JJ
cord-304876-txaoz7oh	34	13	,	,	,
cord-304876-txaoz7oh	34	14	pulmonary	pulmonary	JJ
cord-304876-txaoz7oh	34	15	,	,	,
cord-304876-txaoz7oh	34	16	or	or	CC
cord-304876-txaoz7oh	34	17	immune	immune	JJ
cord-304876-txaoz7oh	34	18	systems	system	NNS
cord-304876-txaoz7oh	34	19	are	be	VBP
cord-304876-txaoz7oh	34	20	at	at	IN
cord-304876-txaoz7oh	34	21	greatest	great	JJS
cord-304876-txaoz7oh	34	22	risk	risk	NN
cord-304876-txaoz7oh	34	23	for	for	IN
cord-304876-txaoz7oh	34	24	serious	serious	JJ
cord-304876-txaoz7oh	34	25	disease	disease	NN
cord-304876-txaoz7oh	34	26	associated	associate	VBN
cord-304876-txaoz7oh	34	27	with	with	IN
cord-304876-txaoz7oh	34	28	these	these	DT
cord-304876-txaoz7oh	34	29	RNA	RNA	NNP
cord-304876-txaoz7oh	34	30	virus	virus	NN
cord-304876-txaoz7oh	34	31	respiratory	respiratory	JJ
cord-304876-txaoz7oh	34	32	infections	infection	NNS
cord-304876-txaoz7oh	34	33	.	.	.
cord-304876-txaoz7oh	35	1	In	in	IN
cord-304876-txaoz7oh	35	2	a	a	DT
cord-304876-txaoz7oh	35	3	10-year	10-year	CD
cord-304876-txaoz7oh	35	4	study	study	NN
cord-304876-txaoz7oh	35	5	,	,	,
cord-304876-txaoz7oh	35	6	over	over	IN
cord-304876-txaoz7oh	35	7	85	85	CD
cord-304876-txaoz7oh	35	8	%	%	NN
cord-304876-txaoz7oh	35	9	of	of	IN
cord-304876-txaoz7oh	35	10	acute	acute	JJ
cord-304876-txaoz7oh	35	11	respiratory	respiratory	JJ
cord-304876-txaoz7oh	35	12	viral	viral	JJ
cord-304876-txaoz7oh	35	13	infections	infection	NNS
cord-304876-txaoz7oh	35	14	in	in	IN
cord-304876-txaoz7oh	35	15	critically	critically	RB
cord-304876-txaoz7oh	35	16	ill	ill	JJ
cord-304876-txaoz7oh	35	17	children	child	NNS
cord-304876-txaoz7oh	35	18	admitted	admit	VBN
cord-304876-txaoz7oh	35	19	to	to	IN
cord-304876-txaoz7oh	35	20	a	a	DT
cord-304876-txaoz7oh	35	21	pediatric	pediatric	JJ
cord-304876-txaoz7oh	35	22	intensive	intensive	JJ
cord-304876-txaoz7oh	35	23	care	care	NN
cord-304876-txaoz7oh	35	24	unit	unit	NN
cord-304876-txaoz7oh	35	25	were	be	VBD
cord-304876-txaoz7oh	35	26	caused	cause	VBN
cord-304876-txaoz7oh	35	27	by	by	IN
cord-304876-txaoz7oh	35	28	either	either	CC
cord-304876-txaoz7oh	35	29	a	a	DT
cord-304876-txaoz7oh	35	30	picornavirus	picornavirus	NN
cord-304876-txaoz7oh	35	31	,	,	,
cord-304876-txaoz7oh	35	32	RSV	RSV	NNP
cord-304876-txaoz7oh	35	33	,	,	,
cord-304876-txaoz7oh	35	34	PIV	PIV	NNP
cord-304876-txaoz7oh	35	35	,	,	,
cord-304876-txaoz7oh	35	36	or	or	CC
cord-304876-txaoz7oh	35	37	HMPV	HMPV	NNP
cord-304876-txaoz7oh	35	38	(	(	-LRB-
cord-304876-txaoz7oh	35	39	see	see	VB
cord-304876-txaoz7oh	35	40	Figure	figure	NN
cord-304876-txaoz7oh	35	41	1	1	CD
cord-304876-txaoz7oh	35	42	)	)	-RRB-
cord-304876-txaoz7oh	35	43	.	.	.
cord-304876-txaoz7oh	36	1	4	4	LS
cord-304876-txaoz7oh	37	1	Other	other	JJ
cord-304876-txaoz7oh	37	2	DNA	dna	NN
cord-304876-txaoz7oh	37	3	viruses	virus	NNS
cord-304876-txaoz7oh	37	4	such	such	JJ
cord-304876-txaoz7oh	37	5	as	as	IN
cord-304876-txaoz7oh	37	6	adenovirus	adenovirus	NN
cord-304876-txaoz7oh	37	7	can	can	MD
cord-304876-txaoz7oh	37	8	be	be	VB
cord-304876-txaoz7oh	37	9	the	the	DT
cord-304876-txaoz7oh	37	10	source	source	NN
cord-304876-txaoz7oh	37	11	of	of	IN
cord-304876-txaoz7oh	37	12	respiratory	respiratory	JJ
cord-304876-txaoz7oh	37	13	infections	infection	NNS
cord-304876-txaoz7oh	37	14	but	but	CC
cord-304876-txaoz7oh	37	15	will	will	MD
cord-304876-txaoz7oh	37	16	not	not	RB
cord-304876-txaoz7oh	37	17	be	be	VB
cord-304876-txaoz7oh	37	18	discussed	discuss	VBN
cord-304876-txaoz7oh	37	19	here	here	RB
cord-304876-txaoz7oh	37	20	.	.	.
cord-304876-txaoz7oh	38	1	In	in	IN
cord-304876-txaoz7oh	38	2	addition	addition	NN
cord-304876-txaoz7oh	38	3	to	to	IN
cord-304876-txaoz7oh	38	4	their	-PRON-	PRP$
cord-304876-txaoz7oh	38	5	wide	wide	JJ
cord-304876-txaoz7oh	38	6	variation	variation	NN
cord-304876-txaoz7oh	38	7	in	in	IN
cord-304876-txaoz7oh	38	8	viral	viral	JJ
cord-304876-txaoz7oh	38	9	characteristics	characteristic	NNS
cord-304876-txaoz7oh	38	10	,	,	,
cord-304876-txaoz7oh	38	11	respiratory	respiratory	JJ
cord-304876-txaoz7oh	38	12	RNA	RNA	NNP
cord-304876-txaoz7oh	38	13	viruses	virus	NNS
cord-304876-txaoz7oh	38	14	are	be	VBP
cord-304876-txaoz7oh	38	15	also	also	RB
cord-304876-txaoz7oh	38	16	remarkable	remarkable	JJ
cord-304876-txaoz7oh	38	17	in	in	IN
cord-304876-txaoz7oh	38	18	their	-PRON-	PRP$
cord-304876-txaoz7oh	38	19	epidemiological	epidemiological	JJ
cord-304876-txaoz7oh	38	20	variety	variety	NN
cord-304876-txaoz7oh	38	21	.	.	.
cord-304876-txaoz7oh	39	1	They	-PRON-	PRP
cord-304876-txaoz7oh	39	2	differ	differ	VBP
cord-304876-txaoz7oh	39	3	in	in	IN
cord-304876-txaoz7oh	39	4	(	(	-LRB-
cord-304876-txaoz7oh	39	5	1	1	CD
cord-304876-txaoz7oh	39	6	)	)	-RRB-
cord-304876-txaoz7oh	39	7	their	-PRON-	PRP$
cord-304876-txaoz7oh	39	8	outbreak	outbreak	NN
cord-304876-txaoz7oh	39	9	calendar	calendar	NN
cord-304876-txaoz7oh	39	10	,	,	,
cord-304876-txaoz7oh	39	11	where	where	WRB
cord-304876-txaoz7oh	39	12	some	some	DT
cord-304876-txaoz7oh	39	13	are	be	VBP
cord-304876-txaoz7oh	39	14	seasonal	seasonal	JJ
cord-304876-txaoz7oh	39	15	and	and	CC
cord-304876-txaoz7oh	39	16	others	other	NNS
cord-304876-txaoz7oh	39	17	are	be	VBP
cord-304876-txaoz7oh	39	18	year	year	NN
cord-304876-txaoz7oh	39	19	-	-	HYPH
cord-304876-txaoz7oh	39	20	round	round	NN
cord-304876-txaoz7oh	39	21	,	,	,
cord-304876-txaoz7oh	39	22	(	(	-LRB-
cord-304876-txaoz7oh	39	23	2	2	LS
cord-304876-txaoz7oh	39	24	)	)	-RRB-
cord-304876-txaoz7oh	39	25	their	-PRON-	PRP$
cord-304876-txaoz7oh	39	26	patient	patient	NN
cord-304876-txaoz7oh	39	27	profile	profile	NN
cord-304876-txaoz7oh	39	28	,	,	,
cord-304876-txaoz7oh	39	29	whether	whether	IN
cord-304876-txaoz7oh	39	30	infant	infant	NN
cord-304876-txaoz7oh	39	31	,	,	,
cord-304876-txaoz7oh	39	32	geriatric	geriatric	JJ
cord-304876-txaoz7oh	39	33	,	,	,
cord-304876-txaoz7oh	39	34	or	or	CC
cord-304876-txaoz7oh	39	35	otherwise	otherwise	RB
cord-304876-txaoz7oh	39	36	healthy	healthy	JJ
cord-304876-txaoz7oh	39	37	adults	adult	NNS
cord-304876-txaoz7oh	39	38	,	,	,
cord-304876-txaoz7oh	39	39	and	and	CC
cord-304876-txaoz7oh	39	40	(	(	-LRB-
cord-304876-txaoz7oh	39	41	3	3	LS
cord-304876-txaoz7oh	39	42	)	)	-RRB-
cord-304876-txaoz7oh	39	43	the	the	DT
cord-304876-txaoz7oh	39	44	morbidity	morbidity	NN
cord-304876-txaoz7oh	39	45	and/or	and/or	CC
cord-304876-txaoz7oh	39	46	mortality	mortality	NN
cord-304876-txaoz7oh	39	47	associated	associate	VBN
cord-304876-txaoz7oh	39	48	with	with	IN
cord-304876-txaoz7oh	39	49	infection	infection	NN
cord-304876-txaoz7oh	39	50	.	.	.
cord-304876-txaoz7oh	40	1	Influenza	influenza	NN
cord-304876-txaoz7oh	40	2	virus	virus	NN
cord-304876-txaoz7oh	40	3	is	be	VBZ
cord-304876-txaoz7oh	40	4	a	a	DT
cord-304876-txaoz7oh	40	5	(	(	-LRB-
cord-304876-txaoz7oh	40	6	-)ssRNA	-)ssRNA	NNP
cord-304876-txaoz7oh	40	7	virus	virus	NN
cord-304876-txaoz7oh	40	8	and	and	CC
cord-304876-txaoz7oh	40	9	a	a	DT
cord-304876-txaoz7oh	40	10	member	member	NN
cord-304876-txaoz7oh	40	11	of	of	IN
cord-304876-txaoz7oh	40	12	the	the	DT
cord-304876-txaoz7oh	40	13	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-304876-txaoz7oh	40	14	family	family	NN
cord-304876-txaoz7oh	40	15	.	.	.
cord-304876-txaoz7oh	41	1	5	5	LS
cord-304876-txaoz7oh	42	1	There	there	EX
cord-304876-txaoz7oh	42	2	are	be	VBP
cord-304876-txaoz7oh	42	3	four	four	CD
cord-304876-txaoz7oh	42	4	influenza	influenza	NN
cord-304876-txaoz7oh	42	5	genera	genus	NNS
cord-304876-txaoz7oh	42	6	within	within	IN
cord-304876-txaoz7oh	42	7	this	this	DT
cord-304876-txaoz7oh	42	8	family	family	NN
cord-304876-txaoz7oh	42	9	,	,	,
cord-304876-txaoz7oh	42	10	called	call	VBN
cord-304876-txaoz7oh	42	11	A	A	NNP
cord-304876-txaoz7oh	42	12	,	,	,
cord-304876-txaoz7oh	42	13	B	B	NNP
cord-304876-txaoz7oh	42	14	,	,	,
cord-304876-txaoz7oh	42	15	C	C	NNP
cord-304876-txaoz7oh	42	16	,	,	,
cord-304876-txaoz7oh	42	17	or	or	CC
cord-304876-txaoz7oh	42	18	D.	D.	NNP
cord-304876-txaoz7oh	42	19	Influenza	Influenza	NNP
cord-304876-txaoz7oh	42	20	A	A	NNP
cord-304876-txaoz7oh	42	21	and	and	CC
cord-304876-txaoz7oh	42	22	B	b	NN
cord-304876-txaoz7oh	43	1	contain	contain	VB
cord-304876-txaoz7oh	43	2	hemagglutinin	hemagglutinin	NN
cord-304876-txaoz7oh	43	3	and	and	CC
cord-304876-txaoz7oh	43	4	neuraminidase	neuraminidase	NN
cord-304876-txaoz7oh	43	5	envelope	envelope	NN
cord-304876-txaoz7oh	43	6	glycoproteins	glycoprotein	NNS
cord-304876-txaoz7oh	43	7	.	.	.
cord-304876-txaoz7oh	44	1	Influenza	Influenza	NNP
cord-304876-txaoz7oh	44	2	C	C	NNP
cord-304876-txaoz7oh	44	3	and	and	CC
cord-304876-txaoz7oh	44	4	D	D	NNP
cord-304876-txaoz7oh	44	5	have	have	VBP
cord-304876-txaoz7oh	44	6	a	a	DT
cord-304876-txaoz7oh	44	7	single	single	JJ
cord-304876-txaoz7oh	44	8	surface	surface	NN
cord-304876-txaoz7oh	44	9	glycoprotein	glycoprotein	NN
cord-304876-txaoz7oh	44	10	called	call	VBN
cord-304876-txaoz7oh	44	11	the	the	DT
cord-304876-txaoz7oh	44	12	hemagglutinin	hemagglutinin	NN
cord-304876-txaoz7oh	44	13	-	-	HYPH
cord-304876-txaoz7oh	44	14	esterase	esterase	NN
cord-304876-txaoz7oh	44	15	fusion	fusion	NN
cord-304876-txaoz7oh	44	16	protein	protein	NN
cord-304876-txaoz7oh	44	17	.	.	.
cord-304876-txaoz7oh	45	1	6	6	CD
cord-304876-txaoz7oh	45	2	,	,	,
cord-304876-txaoz7oh	45	3	7	7	CD
cord-304876-txaoz7oh	45	4	Antigenic	antigenic	JJ
cord-304876-txaoz7oh	45	5	variation	variation	NN
cord-304876-txaoz7oh	45	6	in	in	IN
cord-304876-txaoz7oh	45	7	these	these	DT
cord-304876-txaoz7oh	45	8	glycoproteins	glycoprotein	NNS
cord-304876-txaoz7oh	45	9	results	result	NNS
cord-304876-txaoz7oh	45	10	in	in	IN
cord-304876-txaoz7oh	45	11	limited	limited	JJ
cord-304876-txaoz7oh	45	12	vaccine	vaccine	NN
cord-304876-txaoz7oh	45	13	protection	protection	NN
cord-304876-txaoz7oh	45	14	.	.	.
cord-304876-txaoz7oh	46	1	Influenza	Influenza	NNP
cord-304876-txaoz7oh	46	2	,	,	,
cord-304876-txaoz7oh	46	3	or	or	CC
cord-304876-txaoz7oh	46	4	the	the	DT
cord-304876-txaoz7oh	46	5	flu	flu	NN
cord-304876-txaoz7oh	46	6	,	,	,
cord-304876-txaoz7oh	46	7	presents	present	VBZ
cord-304876-txaoz7oh	46	8	with	with	IN
cord-304876-txaoz7oh	46	9	symptoms	symptom	NNS
cord-304876-txaoz7oh	46	10	such	such	JJ
cord-304876-txaoz7oh	46	11	as	as	IN
cord-304876-txaoz7oh	46	12	headache	headache	NN
cord-304876-txaoz7oh	46	13	,	,	,
cord-304876-txaoz7oh	46	14	cough	cough	NN
cord-304876-txaoz7oh	46	15	,	,	,
cord-304876-txaoz7oh	46	16	fever	fever	NN
cord-304876-txaoz7oh	46	17	,	,	,
cord-304876-txaoz7oh	46	18	sore	sore	JJ
cord-304876-txaoz7oh	46	19	throat	throat	NN
cord-304876-txaoz7oh	46	20	,	,	,
cord-304876-txaoz7oh	46	21	malaise	malaise	NN
cord-304876-txaoz7oh	46	22	,	,	,
cord-304876-txaoz7oh	46	23	and	and	CC
cord-304876-txaoz7oh	46	24	chills	chill	NNS
cord-304876-txaoz7oh	46	25	.	.	.
cord-304876-txaoz7oh	47	1	8	8	CD
cord-304876-txaoz7oh	48	1	Generally	generally	RB
cord-304876-txaoz7oh	48	2	,	,	,
cord-304876-txaoz7oh	48	3	the	the	DT
cord-304876-txaoz7oh	48	4	flu	flu	NN
cord-304876-txaoz7oh	48	5	lasts	last	VBZ
cord-304876-txaoz7oh	48	6	from	from	IN
cord-304876-txaoz7oh	48	7	5	5	CD
cord-304876-txaoz7oh	48	8	days	day	NNS
cord-304876-txaoz7oh	48	9	to	to	IN
cord-304876-txaoz7oh	48	10	2	2	CD
cord-304876-txaoz7oh	48	11	weeks	week	NNS
cord-304876-txaoz7oh	48	12	and	and	CC
cord-304876-txaoz7oh	48	13	the	the	DT
cord-304876-txaoz7oh	48	14	severity	severity	NN
cord-304876-txaoz7oh	48	15	of	of	IN
cord-304876-txaoz7oh	48	16	infection	infection	NN
cord-304876-txaoz7oh	48	17	is	be	VBZ
cord-304876-txaoz7oh	48	18	determined	determine	VBN
cord-304876-txaoz7oh	48	19	by	by	IN
cord-304876-txaoz7oh	48	20	the	the	DT
cord-304876-txaoz7oh	48	21	host	host	NN
cord-304876-txaoz7oh	48	22	.	.	.
cord-304876-txaoz7oh	49	1	The	the	DT
cord-304876-txaoz7oh	49	2	highest	high	JJS
cord-304876-txaoz7oh	49	3	incidence	incidence	NN
cord-304876-txaoz7oh	49	4	of	of	IN
cord-304876-txaoz7oh	49	5	influenza	influenza	NN
cord-304876-txaoz7oh	49	6	infection	infection	NN
cord-304876-txaoz7oh	49	7	occurs	occur	VBZ
cord-304876-txaoz7oh	49	8	in	in	IN
cord-304876-txaoz7oh	49	9	younger	young	JJR
cord-304876-txaoz7oh	49	10	patients	patient	NNS
cord-304876-txaoz7oh	49	11	(	(	-LRB-
cord-304876-txaoz7oh	49	12	<	<	NNP
cord-304876-txaoz7oh	49	13	25	25	CD
cord-304876-txaoz7oh	49	14	years	year	NNS
cord-304876-txaoz7oh	49	15	old	old	JJ
cord-304876-txaoz7oh	49	16	)	)	-RRB-
cord-304876-txaoz7oh	49	17	where	where	WRB
cord-304876-txaoz7oh	49	18	a	a	DT
cord-304876-txaoz7oh	49	19	shorter	short	JJR
cord-304876-txaoz7oh	49	20	infection	infection	NN
cord-304876-txaoz7oh	49	21	is	be	VBZ
cord-304876-txaoz7oh	49	22	typical	typical	JJ
cord-304876-txaoz7oh	49	23	,	,	,
cord-304876-txaoz7oh	49	24	while	while	IN
cord-304876-txaoz7oh	49	25	those	those	DT
cord-304876-txaoz7oh	49	26	at	at	IN
cord-304876-txaoz7oh	49	27	risk	risk	NN
cord-304876-txaoz7oh	49	28	for	for	IN
cord-304876-txaoz7oh	49	29	longer	long	JJR
cord-304876-txaoz7oh	49	30	and	and	CC
cord-304876-txaoz7oh	49	31	more	more	RBR
cord-304876-txaoz7oh	49	32	severe	severe	JJ
cord-304876-txaoz7oh	49	33	illness	illness	NN
cord-304876-txaoz7oh	49	34	and	and	CC
cord-304876-txaoz7oh	49	35	complications	complication	NNS
cord-304876-txaoz7oh	49	36	associated	associate	VBN
cord-304876-txaoz7oh	49	37	with	with	IN
cord-304876-txaoz7oh	49	38	infection	infection	NN
cord-304876-txaoz7oh	49	39	are	be	VBP
cord-304876-txaoz7oh	49	40	the	the	DT
cord-304876-txaoz7oh	49	41	pediatric	pediatric	JJ
cord-304876-txaoz7oh	49	42	(	(	-LRB-
cord-304876-txaoz7oh	49	43	<	<	NNP
cord-304876-txaoz7oh	49	44	2	2	CD
cord-304876-txaoz7oh	49	45	years	year	NNS
cord-304876-txaoz7oh	49	46	old	old	JJ
cord-304876-txaoz7oh	49	47	)	)	-RRB-
cord-304876-txaoz7oh	49	48	and	and	CC
cord-304876-txaoz7oh	49	49	geriatric	geriatric	JJ
cord-304876-txaoz7oh	49	50	populations	population	NNS
cord-304876-txaoz7oh	49	51	(	(	-LRB-
cord-304876-txaoz7oh	49	52	>	>	NFP
cord-304876-txaoz7oh	49	53	65	65	CD
cord-304876-txaoz7oh	49	54	years	year	NNS
cord-304876-txaoz7oh	49	55	old	old	JJ
cord-304876-txaoz7oh	49	56	)	)	-RRB-
cord-304876-txaoz7oh	49	57	,	,	,
cord-304876-txaoz7oh	49	58	pregnant	pregnant	JJ
cord-304876-txaoz7oh	49	59	women	woman	NNS
cord-304876-txaoz7oh	49	60	,	,	,
cord-304876-txaoz7oh	49	61	and	and	CC
cord-304876-txaoz7oh	49	62	immunocompromised	immunocompromised	JJ
cord-304876-txaoz7oh	49	63	individuals	individual	NNS
cord-304876-txaoz7oh	49	64	.	.	.
cord-304876-txaoz7oh	50	1	9	9	CD
cord-304876-txaoz7oh	50	2	,	,	,
cord-304876-txaoz7oh	50	3	10	10	CD
cord-304876-txaoz7oh	51	1	It	-PRON-	PRP
cord-304876-txaoz7oh	51	2	is	be	VBZ
cord-304876-txaoz7oh	51	3	estimated	estimate	VBN
cord-304876-txaoz7oh	51	4	that	that	IN
cord-304876-txaoz7oh	51	5	3	3	CD
cord-304876-txaoz7oh	51	6	-	-	SYM
cord-304876-txaoz7oh	51	7	5	5	CD
cord-304876-txaoz7oh	51	8	million	million	CD
cord-304876-txaoz7oh	51	9	cases	case	NNS
cord-304876-txaoz7oh	51	10	of	of	IN
cord-304876-txaoz7oh	51	11	the	the	DT
cord-304876-txaoz7oh	51	12	flu	flu	NN
cord-304876-txaoz7oh	51	13	occur	occur	VBP
cord-304876-txaoz7oh	51	14	annually	annually	RB
cord-304876-txaoz7oh	51	15	around	around	IN
cord-304876-txaoz7oh	51	16	the	the	DT
cord-304876-txaoz7oh	51	17	globe	globe	NN
cord-304876-txaoz7oh	51	18	,	,	,
cord-304876-txaoz7oh	51	19	with	with	IN
cord-304876-txaoz7oh	51	20	a	a	DT
cord-304876-txaoz7oh	51	21	quarter	quarter	NN
cord-304876-txaoz7oh	51	22	to	to	IN
cord-304876-txaoz7oh	51	23	half	half	CD
cord-304876-txaoz7oh	51	24	million	million	CD
cord-304876-txaoz7oh	51	25	deaths	death	NNS
cord-304876-txaoz7oh	51	26	resulting	result	VBG
cord-304876-txaoz7oh	51	27	from	from	IN
cord-304876-txaoz7oh	51	28	these	these	DT
cord-304876-txaoz7oh	51	29	illnesses	illness	NNS
cord-304876-txaoz7oh	51	30	.	.	.
cord-304876-txaoz7oh	52	1	11	11	CD
cord-304876-txaoz7oh	52	2	PIV	PIV	NNP
cord-304876-txaoz7oh	52	3	(	(	-LRB-
cord-304876-txaoz7oh	52	4	Paramyxoviridae	Paramyxoviridae	NNP
cord-304876-txaoz7oh	52	5	family	family	NN
cord-304876-txaoz7oh	52	6	)	)	-RRB-
cord-304876-txaoz7oh	52	7	,	,	,
cord-304876-txaoz7oh	52	8	RSV	RSV	NNP
cord-304876-txaoz7oh	52	9	,	,	,
cord-304876-txaoz7oh	52	10	and	and	CC
cord-304876-txaoz7oh	52	11	HMPV	HMPV	NNP
cord-304876-txaoz7oh	52	12	(	(	-LRB-
cord-304876-txaoz7oh	52	13	Pneumoviridae	Pneumoviridae	NNP
cord-304876-txaoz7oh	52	14	family	family	NN
cord-304876-txaoz7oh	52	15	)	)	-RRB-
cord-304876-txaoz7oh	53	1	Until	until	IN
cord-304876-txaoz7oh	53	2	recently	recently	RB
cord-304876-txaoz7oh	53	3	,	,	,
cord-304876-txaoz7oh	53	4	PIV	PIV	NNP
cord-304876-txaoz7oh	53	5	,	,	,
cord-304876-txaoz7oh	53	6	HMPV	HMPV	NNP
cord-304876-txaoz7oh	53	7	,	,	,
cord-304876-txaoz7oh	53	8	and	and	CC
cord-304876-txaoz7oh	53	9	RSV	RSV	NNP
cord-304876-txaoz7oh	53	10	were	be	VBD
cord-304876-txaoz7oh	53	11	all	all	DT
cord-304876-txaoz7oh	53	12	categorized	categorize	VBN
cord-304876-txaoz7oh	53	13	in	in	IN
cord-304876-txaoz7oh	53	14	the	the	DT
cord-304876-txaoz7oh	53	15	Paramyxoviridae	Paramyxoviridae	NNP
cord-304876-txaoz7oh	53	16	family	family	NN
cord-304876-txaoz7oh	53	17	due	due	IN
cord-304876-txaoz7oh	53	18	to	to	IN
cord-304876-txaoz7oh	53	19	their	-PRON-	PRP$
cord-304876-txaoz7oh	53	20	phylogenetic	phylogenetic	JJ
cord-304876-txaoz7oh	53	21	proximity	proximity	NN
cord-304876-txaoz7oh	53	22	in	in	IN
cord-304876-txaoz7oh	53	23	the	the	DT
cord-304876-txaoz7oh	53	24	order	order	NN
cord-304876-txaoz7oh	53	25	Mononegavirales	Mononegavirales	NNP
cord-304876-txaoz7oh	53	26	,	,	,
cord-304876-txaoz7oh	53	27	the	the	DT
cord-304876-txaoz7oh	53	28	non	non	JJ
cord-304876-txaoz7oh	53	29	-	-	JJ
cord-304876-txaoz7oh	53	30	segmented	segmented	JJ
cord-304876-txaoz7oh	53	31	negative	negative	JJ
cord-304876-txaoz7oh	53	32	-	-	HYPH
cord-304876-txaoz7oh	53	33	strand	strand	NN
cord-304876-txaoz7oh	53	34	RNA	RNA	NNP
cord-304876-txaoz7oh	53	35	viruses	virus	NNS
cord-304876-txaoz7oh	53	36	.	.	.
cord-304876-txaoz7oh	54	1	More	more	RBR
cord-304876-txaoz7oh	54	2	recently	recently	RB
cord-304876-txaoz7oh	54	3	,	,	,
cord-304876-txaoz7oh	54	4	RSV	RSV	NNP
cord-304876-txaoz7oh	54	5	and	and	CC
cord-304876-txaoz7oh	54	6	HMPV	HMPV	NNP
cord-304876-txaoz7oh	54	7	have	have	VBP
cord-304876-txaoz7oh	54	8	been	be	VBN
cord-304876-txaoz7oh	54	9	assigned	assign	VBN
cord-304876-txaoz7oh	54	10	as	as	IN
cord-304876-txaoz7oh	54	11	members	member	NNS
cord-304876-txaoz7oh	54	12	of	of	IN
cord-304876-txaoz7oh	54	13	the	the	DT
cord-304876-txaoz7oh	54	14	newly	newly	RB
cord-304876-txaoz7oh	54	15	formed	form	VBN
cord-304876-txaoz7oh	54	16	Pneumoviridae	Pneumoviridae	NNP
cord-304876-txaoz7oh	54	17	family	family	NN
cord-304876-txaoz7oh	54	18	.	.	.
cord-304876-txaoz7oh	55	1	12	12	CD
cord-304876-txaoz7oh	56	1	While	while	IN
cord-304876-txaoz7oh	56	2	influenza	influenza	NN
cord-304876-txaoz7oh	56	3	outbreaks	outbreak	NNS
cord-304876-txaoz7oh	56	4	are	be	VBP
cord-304876-txaoz7oh	56	5	most	most	RBS
cord-304876-txaoz7oh	56	6	prevalent	prevalent	JJ
cord-304876-txaoz7oh	56	7	in	in	IN
cord-304876-txaoz7oh	56	8	the	the	DT
cord-304876-txaoz7oh	56	9	winter	winter	NN
cord-304876-txaoz7oh	56	10	,	,	,
cord-304876-txaoz7oh	56	11	some	some	DT
cord-304876-txaoz7oh	56	12	viruses	virus	NNS
cord-304876-txaoz7oh	56	13	such	such	JJ
cord-304876-txaoz7oh	56	14	as	as	IN
cord-304876-txaoz7oh	56	15	PIV	PIV	NNP
cord-304876-txaoz7oh	56	16	persist	persist	VBP
cord-304876-txaoz7oh	56	17	year	year	NN
cord-304876-txaoz7oh	56	18	-	-	HYPH
cord-304876-txaoz7oh	56	19	round	round	NN
cord-304876-txaoz7oh	56	20	.	.	.
cord-304876-txaoz7oh	57	1	Human	human	JJ
cord-304876-txaoz7oh	57	2	PIV	PIV	NNP
cord-304876-txaoz7oh	57	3	has	have	VBZ
cord-304876-txaoz7oh	57	4	four	four	CD
cord-304876-txaoz7oh	57	5	types	type	NNS
cord-304876-txaoz7oh	57	6	(	(	-LRB-
cord-304876-txaoz7oh	57	7	1	1	CD
cord-304876-txaoz7oh	57	8	to	to	IN
cord-304876-txaoz7oh	57	9	4	4	CD
cord-304876-txaoz7oh	57	10	)	)	-RRB-
cord-304876-txaoz7oh	57	11	and	and	CC
cord-304876-txaoz7oh	57	12	was	be	VBD
cord-304876-txaoz7oh	57	13	known	know	VBN
cord-304876-txaoz7oh	57	14	historically	historically	RB
cord-304876-txaoz7oh	57	15	to	to	TO
cord-304876-txaoz7oh	57	16	induce	induce	VB
cord-304876-txaoz7oh	57	17	respiratory	respiratory	JJ
cord-304876-txaoz7oh	57	18	complications	complication	NNS
cord-304876-txaoz7oh	57	19	mainly	mainly	RB
cord-304876-txaoz7oh	57	20	in	in	IN
cord-304876-txaoz7oh	57	21	children	child	NNS
cord-304876-txaoz7oh	57	22	and	and	CC
cord-304876-txaoz7oh	57	23	the	the	DT
cord-304876-txaoz7oh	57	24	immunocompromised	immunocompromised	JJ
cord-304876-txaoz7oh	57	25	;	;	:
cord-304876-txaoz7oh	57	26	however	however	RB
cord-304876-txaoz7oh	57	27	,	,	,
cord-304876-txaoz7oh	57	28	more	more	RBR
cord-304876-txaoz7oh	57	29	recently	recently	RB
cord-304876-txaoz7oh	57	30	,	,	,
cord-304876-txaoz7oh	57	31	it	-PRON-	PRP
cord-304876-txaoz7oh	57	32	has	have	VBZ
cord-304876-txaoz7oh	57	33	been	be	VBN
cord-304876-txaoz7oh	57	34	identified	identify	VBN
cord-304876-txaoz7oh	57	35	as	as	IN
cord-304876-txaoz7oh	57	36	a	a	DT
cord-304876-txaoz7oh	57	37	concern	concern	NN
cord-304876-txaoz7oh	57	38	in	in	IN
cord-304876-txaoz7oh	57	39	the	the	DT
cord-304876-txaoz7oh	57	40	adult	adult	NN
cord-304876-txaoz7oh	57	41	population	population	NN
cord-304876-txaoz7oh	57	42	as	as	RB
cord-304876-txaoz7oh	57	43	well	well	RB
cord-304876-txaoz7oh	57	44	.	.	.
cord-304876-txaoz7oh	58	1	13	13	CD
cord-304876-txaoz7oh	58	2	Symptoms	symptom	NNS
cord-304876-txaoz7oh	58	3	of	of	IN
cord-304876-txaoz7oh	58	4	PIV	PIV	NNP
cord-304876-txaoz7oh	58	5	include	include	VBP
cord-304876-txaoz7oh	58	6	upper	upper	JJ
cord-304876-txaoz7oh	58	7	and	and	CC
cord-304876-txaoz7oh	58	8	lower	low	JJR
cord-304876-txaoz7oh	58	9	respiratory	respiratory	JJ
cord-304876-txaoz7oh	58	10	tract	tract	NN
cord-304876-txaoz7oh	58	11	infection	infection	NN
cord-304876-txaoz7oh	58	12	,	,	,
cord-304876-txaoz7oh	58	13	middle	middle	JJ
cord-304876-txaoz7oh	58	14	ear	ear	NN
cord-304876-txaoz7oh	58	15	inflammation	inflammation	NN
cord-304876-txaoz7oh	58	16	,	,	,
cord-304876-txaoz7oh	58	17	bronchitis	bronchitis	NN
cord-304876-txaoz7oh	58	18	,	,	,
cord-304876-txaoz7oh	58	19	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	58	20	,	,	,
cord-304876-txaoz7oh	58	21	and	and	CC
cord-304876-txaoz7oh	58	22	croup	croup	NN
cord-304876-txaoz7oh	58	23	,	,	,
cord-304876-txaoz7oh	58	24	the	the	DT
cord-304876-txaoz7oh	58	25	last	last	JJ
cord-304876-txaoz7oh	58	26	of	of	IN
cord-304876-txaoz7oh	58	27	which	which	WDT
cord-304876-txaoz7oh	58	28	results	result	VBZ
cord-304876-txaoz7oh	58	29	in	in	IN
cord-304876-txaoz7oh	58	30	the	the	DT
cord-304876-txaoz7oh	58	31	most	most	JJS
cord-304876-txaoz7oh	58	32	hospitalizations	hospitalization	NNS
cord-304876-txaoz7oh	58	33	in	in	IN
cord-304876-txaoz7oh	58	34	the	the	DT
cord-304876-txaoz7oh	58	35	pediatric	pediatric	JJ
cord-304876-txaoz7oh	58	36	patients	patient	NNS
cord-304876-txaoz7oh	58	37	infected	infect	VBN
cord-304876-txaoz7oh	58	38	by	by	IN
cord-304876-txaoz7oh	58	39	this	this	DT
cord-304876-txaoz7oh	58	40	virus	virus	NN
cord-304876-txaoz7oh	58	41	.	.	.
cord-304876-txaoz7oh	59	1	14	14	CD
cord-304876-txaoz7oh	59	2	,	,	,
cord-304876-txaoz7oh	59	3	15	15	CD
cord-304876-txaoz7oh	59	4	Up	up	IN
cord-304876-txaoz7oh	59	5	to	to	IN
cord-304876-txaoz7oh	59	6	one	one	CD
cord-304876-txaoz7oh	59	7	-	-	HYPH
cord-304876-txaoz7oh	59	8	third	third	NN
cord-304876-txaoz7oh	59	9	of	of	IN
cord-304876-txaoz7oh	59	10	the	the	DT
cord-304876-txaoz7oh	59	11	nearly	nearly	RB
cord-304876-txaoz7oh	59	12	5	5	CD
cord-304876-txaoz7oh	59	13	million	million	CD
cord-304876-txaoz7oh	59	14	annual	annual	JJ
cord-304876-txaoz7oh	59	15	cases	case	NNS
cord-304876-txaoz7oh	59	16	of	of	IN
cord-304876-txaoz7oh	59	17	lower	low	JJR
cord-304876-txaoz7oh	59	18	respiratory	respiratory	JJ
cord-304876-txaoz7oh	59	19	tract	tract	NN
cord-304876-txaoz7oh	59	20	infection	infection	NN
cord-304876-txaoz7oh	59	21	in	in	IN
cord-304876-txaoz7oh	59	22	children	child	NNS
cord-304876-txaoz7oh	59	23	is	be	VBZ
cord-304876-txaoz7oh	59	24	at	at	IN
cord-304876-txaoz7oh	59	25	least	least	JJS
cord-304876-txaoz7oh	59	26	partially	partially	RB
cord-304876-txaoz7oh	59	27	due	due	JJ
cord-304876-txaoz7oh	59	28	to	to	IN
cord-304876-txaoz7oh	59	29	the	the	DT
cord-304876-txaoz7oh	59	30	presence	presence	NN
cord-304876-txaoz7oh	59	31	of	of	IN
cord-304876-txaoz7oh	59	32	PIVs	piv	NNS
cord-304876-txaoz7oh	59	33	.	.	.
cord-304876-txaoz7oh	60	1	16	16	CD
cord-304876-txaoz7oh	60	2	RSV	RSV	NNP
cord-304876-txaoz7oh	60	3	and	and	CC
cord-304876-txaoz7oh	60	4	PIV	PIV	NNP
cord-304876-txaoz7oh	60	5	infections	infection	NNS
cord-304876-txaoz7oh	60	6	are	be	VBP
cord-304876-txaoz7oh	60	7	among	among	IN
cord-304876-txaoz7oh	60	8	the	the	DT
cord-304876-txaoz7oh	60	9	most	most	RBS
cord-304876-txaoz7oh	60	10	common	common	JJ
cord-304876-txaoz7oh	60	11	reason	reason	NN
cord-304876-txaoz7oh	60	12	for	for	IN
cord-304876-txaoz7oh	60	13	hospitalization	hospitalization	NN
cord-304876-txaoz7oh	60	14	of	of	IN
cord-304876-txaoz7oh	60	15	young	young	JJ
cord-304876-txaoz7oh	60	16	children	child	NNS
cord-304876-txaoz7oh	60	17	.	.	.
cord-304876-txaoz7oh	61	1	17	17	CD
cord-304876-txaoz7oh	61	2	,	,	,
cord-304876-txaoz7oh	61	3	18	18	CD
cord-304876-txaoz7oh	62	1	The	the	DT
cord-304876-txaoz7oh	62	2	two	two	CD
cord-304876-txaoz7oh	62	3	strains	strain	NNS
cord-304876-txaoz7oh	62	4	of	of	IN
cord-304876-txaoz7oh	62	5	RSV	RSV	NNP
cord-304876-txaoz7oh	62	6	,	,	,
cord-304876-txaoz7oh	62	7	A	A	NNP
cord-304876-txaoz7oh	62	8	and	and	CC
cord-304876-txaoz7oh	62	9	B	b	NN
cord-304876-txaoz7oh	62	10	,	,	,
cord-304876-txaoz7oh	62	11	are	be	VBP
cord-304876-txaoz7oh	62	12	distinguished	distinguish	VBN
cord-304876-txaoz7oh	62	13	by	by	IN
cord-304876-txaoz7oh	62	14	genetic	genetic	JJ
cord-304876-txaoz7oh	62	15	variations	variation	NNS
cord-304876-txaoz7oh	62	16	in	in	IN
cord-304876-txaoz7oh	62	17	the	the	DT
cord-304876-txaoz7oh	62	18	G	g	NN
cord-304876-txaoz7oh	62	19	surface	surface	NN
cord-304876-txaoz7oh	62	20	glycoprotein	glycoprotein	NN
cord-304876-txaoz7oh	62	21	.	.	.
cord-304876-txaoz7oh	63	1	19	19	CD
cord-304876-txaoz7oh	63	2	Dissimilar	Dissimilar	NNP
cord-304876-txaoz7oh	63	3	to	to	IN
cord-304876-txaoz7oh	63	4	PIV	PIV	NNP
cord-304876-txaoz7oh	63	5	,	,	,
cord-304876-txaoz7oh	63	6	RSV	RSV	NNP
cord-304876-txaoz7oh	63	7	occurs	occur	VBZ
cord-304876-txaoz7oh	63	8	mostly	mostly	RB
cord-304876-txaoz7oh	63	9	in	in	IN
cord-304876-txaoz7oh	63	10	the	the	DT
cord-304876-txaoz7oh	63	11	winter	winter	NN
cord-304876-txaoz7oh	63	12	months	month	NNS
cord-304876-txaoz7oh	63	13	in	in	IN
cord-304876-txaoz7oh	63	14	its	-PRON-	PRP$
cord-304876-txaoz7oh	63	15	target	target	NN
cord-304876-txaoz7oh	63	16	pediatric	pediatric	JJ
cord-304876-txaoz7oh	63	17	population	population	NN
cord-304876-txaoz7oh	63	18	.	.	.
cord-304876-txaoz7oh	64	1	Symptoms	symptom	NNS
cord-304876-txaoz7oh	64	2	include	include	VBP
cord-304876-txaoz7oh	64	3	runny	runny	JJ
cord-304876-txaoz7oh	64	4	nose	nose	NN
cord-304876-txaoz7oh	64	5	,	,	,
cord-304876-txaoz7oh	64	6	nasal	nasal	NN
cord-304876-txaoz7oh	64	7	inflammation	inflammation	NN
cord-304876-txaoz7oh	64	8	,	,	,
cord-304876-txaoz7oh	64	9	cough	cough	NN
cord-304876-txaoz7oh	64	10	,	,	,
cord-304876-txaoz7oh	64	11	sore	sore	JJ
cord-304876-txaoz7oh	64	12	throat	throat	NN
cord-304876-txaoz7oh	64	13	,	,	,
cord-304876-txaoz7oh	64	14	low	low	JJ
cord-304876-txaoz7oh	64	15	-	-	HYPH
cord-304876-txaoz7oh	64	16	grade	grade	NN
cord-304876-txaoz7oh	64	17	fever	fever	NN
cord-304876-txaoz7oh	64	18	,	,	,
cord-304876-txaoz7oh	64	19	wheezing	wheeze	VBG
cord-304876-txaoz7oh	64	20	,	,	,
cord-304876-txaoz7oh	64	21	bronchiolitis	bronchiolitis	NN
cord-304876-txaoz7oh	64	22	,	,	,
cord-304876-txaoz7oh	64	23	and	and	CC
cord-304876-txaoz7oh	64	24	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	64	25	.	.	.
cord-304876-txaoz7oh	65	1	20	20	CD
cord-304876-txaoz7oh	65	2	Current	current	JJ
cord-304876-txaoz7oh	65	3	estimates	estimate	NNS
cord-304876-txaoz7oh	65	4	in	in	IN
cord-304876-txaoz7oh	65	5	developing	develop	VBG
cord-304876-txaoz7oh	65	6	and	and	CC
cord-304876-txaoz7oh	65	7	industrialized	industrialize	VBN
cord-304876-txaoz7oh	65	8	countries	country	NNS
cord-304876-txaoz7oh	65	9	suggest	suggest	VBP
cord-304876-txaoz7oh	65	10	as	as	RB
cord-304876-txaoz7oh	65	11	many	many	JJ
cord-304876-txaoz7oh	65	12	as	as	IN
cord-304876-txaoz7oh	65	13	33	33	CD
cord-304876-txaoz7oh	65	14	million	million	CD
cord-304876-txaoz7oh	65	15	cases	case	NNS
cord-304876-txaoz7oh	65	16	of	of	IN
cord-304876-txaoz7oh	65	17	RSV	RSV	NNP
cord-304876-txaoz7oh	65	18	worldwide	worldwide	RB
cord-304876-txaoz7oh	65	19	in	in	IN
cord-304876-txaoz7oh	65	20	the	the	DT
cord-304876-txaoz7oh	65	21	pediatric	pediatric	JJ
cord-304876-txaoz7oh	65	22	population	population	NN
cord-304876-txaoz7oh	65	23	less	less	JJR
cord-304876-txaoz7oh	65	24	than	than	IN
cord-304876-txaoz7oh	65	25	5	5	CD
cord-304876-txaoz7oh	65	26	years	year	NNS
cord-304876-txaoz7oh	65	27	old	old	JJ
cord-304876-txaoz7oh	65	28	,	,	,
cord-304876-txaoz7oh	65	29	10	10	CD
cord-304876-txaoz7oh	65	30	%	%	NN
cord-304876-txaoz7oh	65	31	of	of	IN
cord-304876-txaoz7oh	65	32	which	which	WDT
cord-304876-txaoz7oh	65	33	require	require	VBP
cord-304876-txaoz7oh	65	34	hospitalization	hospitalization	NN
cord-304876-txaoz7oh	65	35	,	,	,
cord-304876-txaoz7oh	65	36	and	and	CC
cord-304876-txaoz7oh	65	37	2	2	CD
cord-304876-txaoz7oh	65	38	%	%	NN
cord-304876-txaoz7oh	65	39	to	to	TO
cord-304876-txaoz7oh	65	40	18	18	CD
cord-304876-txaoz7oh	65	41	%	%	NN
cord-304876-txaoz7oh	65	42	of	of	IN
cord-304876-txaoz7oh	65	43	hospitalized	hospitalize	VBN
cord-304876-txaoz7oh	65	44	cases	case	NNS
cord-304876-txaoz7oh	65	45	result	result	VBP
cord-304876-txaoz7oh	65	46	in	in	IN
cord-304876-txaoz7oh	65	47	mortality	mortality	NN
cord-304876-txaoz7oh	65	48	.	.	.
cord-304876-txaoz7oh	66	1	This	this	DT
cord-304876-txaoz7oh	66	2	amounts	amount	VBZ
cord-304876-txaoz7oh	66	3	to	to	IN
cord-304876-txaoz7oh	66	4	between	between	IN
cord-304876-txaoz7oh	66	5	66,000	66,000	CD
cord-304876-txaoz7oh	66	6	and	and	CC
cord-304876-txaoz7oh	66	7	600,000	600,000	CD
cord-304876-txaoz7oh	66	8	deaths	death	NNS
cord-304876-txaoz7oh	66	9	in	in	IN
cord-304876-txaoz7oh	66	10	young	young	JJ
cord-304876-txaoz7oh	66	11	children	child	NNS
cord-304876-txaoz7oh	66	12	annually	annually	RB
cord-304876-txaoz7oh	66	13	.	.	.
cord-304876-txaoz7oh	67	1	18	18	CD
cord-304876-txaoz7oh	67	2	,	,	,
cord-304876-txaoz7oh	67	3	21	21	CD
cord-304876-txaoz7oh	67	4	HMPV	HMPV	NNP
cord-304876-txaoz7oh	67	5	,	,	,
cord-304876-txaoz7oh	67	6	like	like	IN
cord-304876-txaoz7oh	67	7	RSV	RSV	NNP
cord-304876-txaoz7oh	67	8	and	and	CC
cord-304876-txaoz7oh	67	9	influenza	influenza	NN
cord-304876-txaoz7oh	67	10	,	,	,
cord-304876-txaoz7oh	67	11	tends	tend	VBZ
cord-304876-txaoz7oh	67	12	to	to	TO
cord-304876-txaoz7oh	67	13	have	have	VB
cord-304876-txaoz7oh	67	14	greatest	great	JJS
cord-304876-txaoz7oh	67	15	prevalence	prevalence	NN
cord-304876-txaoz7oh	67	16	in	in	IN
cord-304876-txaoz7oh	67	17	the	the	DT
cord-304876-txaoz7oh	67	18	winter	winter	NN
cord-304876-txaoz7oh	67	19	and	and	CC
cord-304876-txaoz7oh	67	20	studies	study	NNS
cord-304876-txaoz7oh	67	21	have	have	VBP
cord-304876-txaoz7oh	67	22	shown	show	VBN
cord-304876-txaoz7oh	67	23	that	that	IN
cord-304876-txaoz7oh	67	24	by	by	IN
cord-304876-txaoz7oh	67	25	the	the	DT
cord-304876-txaoz7oh	67	26	age	age	NN
cord-304876-txaoz7oh	67	27	of	of	IN
cord-304876-txaoz7oh	67	28	5	5	CD
cord-304876-txaoz7oh	67	29	years	year	NNS
cord-304876-txaoz7oh	67	30	,	,	,
cord-304876-txaoz7oh	67	31	nearly	nearly	RB
cord-304876-txaoz7oh	67	32	all	all	DT
cord-304876-txaoz7oh	67	33	children	child	NNS
cord-304876-txaoz7oh	67	34	have	have	VBP
cord-304876-txaoz7oh	67	35	been	be	VBN
cord-304876-txaoz7oh	67	36	infected	infect	VBN
cord-304876-txaoz7oh	67	37	with	with	IN
cord-304876-txaoz7oh	67	38	this	this	DT
cord-304876-txaoz7oh	67	39	virus	virus	NN
cord-304876-txaoz7oh	67	40	.	.	.
cord-304876-txaoz7oh	68	1	22	22	CD
cord-304876-txaoz7oh	69	1	The	the	DT
cord-304876-txaoz7oh	69	2	clinical	clinical	JJ
cord-304876-txaoz7oh	69	3	manifestations	manifestation	NNS
cord-304876-txaoz7oh	69	4	of	of	IN
cord-304876-txaoz7oh	69	5	infection	infection	NN
cord-304876-txaoz7oh	69	6	with	with	IN
cord-304876-txaoz7oh	69	7	this	this	DT
cord-304876-txaoz7oh	69	8	virus	virus	NN
cord-304876-txaoz7oh	69	9	are	be	VBP
cord-304876-txaoz7oh	69	10	upper	upper	JJ
cord-304876-txaoz7oh	69	11	and	and	CC
cord-304876-txaoz7oh	69	12	lower	low	JJR
cord-304876-txaoz7oh	69	13	respiratory	respiratory	JJ
cord-304876-txaoz7oh	69	14	tract	tract	NN
cord-304876-txaoz7oh	69	15	infections	infection	NNS
cord-304876-txaoz7oh	69	16	,	,	,
cord-304876-txaoz7oh	69	17	bronchiolitis	bronchiolitis	NN
cord-304876-txaoz7oh	69	18	,	,	,
cord-304876-txaoz7oh	69	19	middle	middle	JJ
cord-304876-txaoz7oh	69	20	ear	ear	NN
cord-304876-txaoz7oh	69	21	inflammation	inflammation	NN
cord-304876-txaoz7oh	69	22	,	,	,
cord-304876-txaoz7oh	69	23	fever	fever	NN
cord-304876-txaoz7oh	69	24	,	,	,
cord-304876-txaoz7oh	69	25	chills	chill	NNS
cord-304876-txaoz7oh	69	26	,	,	,
cord-304876-txaoz7oh	69	27	pneumonitis	pneumonitis	NN
cord-304876-txaoz7oh	69	28	,	,	,
cord-304876-txaoz7oh	69	29	and	and	CC
cord-304876-txaoz7oh	69	30	wheezing	wheezing	NN
cord-304876-txaoz7oh	69	31	.	.	.
cord-304876-txaoz7oh	70	1	23	23	CD
cord-304876-txaoz7oh	71	1	Of	of	IN
cord-304876-txaoz7oh	71	2	note	note	NN
cord-304876-txaoz7oh	71	3	,	,	,
cord-304876-txaoz7oh	71	4	HMPV	HMPV	NNP
cord-304876-txaoz7oh	71	5	tends	tend	VBZ
cord-304876-txaoz7oh	71	6	to	to	TO
cord-304876-txaoz7oh	71	7	occur	occur	VB
cord-304876-txaoz7oh	71	8	in	in	IN
cord-304876-txaoz7oh	71	9	populations	population	NNS
cord-304876-txaoz7oh	71	10	with	with	IN
cord-304876-txaoz7oh	71	11	seasonal	seasonal	JJ
cord-304876-txaoz7oh	71	12	inconsistency	inconsistency	NN
cord-304876-txaoz7oh	71	13	as	as	IN
cord-304876-txaoz7oh	71	14	studies	study	NNS
cord-304876-txaoz7oh	71	15	done	do	VBN
cord-304876-txaoz7oh	71	16	on	on	IN
cord-304876-txaoz7oh	71	17	Italian	italian	JJ
cord-304876-txaoz7oh	71	18	populations	population	NNS
cord-304876-txaoz7oh	71	19	shortly	shortly	RB
cord-304876-txaoz7oh	71	20	after	after	IN
cord-304876-txaoz7oh	71	21	its	-PRON-	PRP$
cord-304876-txaoz7oh	71	22	discovery	discovery	NN
cord-304876-txaoz7oh	71	23	from	from	IN
cord-304876-txaoz7oh	71	24	2000	2000	CD
cord-304876-txaoz7oh	71	25	-	-	SYM
cord-304876-txaoz7oh	71	26	2002	2002	CD
cord-304876-txaoz7oh	71	27	,	,	,
cord-304876-txaoz7oh	71	28	showed	show	VBD
cord-304876-txaoz7oh	71	29	a	a	DT
cord-304876-txaoz7oh	71	30	range	range	NN
cord-304876-txaoz7oh	71	31	of	of	IN
cord-304876-txaoz7oh	71	32	infection	infection	NN
cord-304876-txaoz7oh	71	33	from	from	IN
cord-304876-txaoz7oh	71	34	7	7	CD
cord-304876-txaoz7oh	71	35	%	%	NN
cord-304876-txaoz7oh	71	36	to	to	IN
cord-304876-txaoz7oh	71	37	40	40	CD
cord-304876-txaoz7oh	71	38	%	%	NN
cord-304876-txaoz7oh	71	39	depending	depend	VBG
cord-304876-txaoz7oh	71	40	on	on	IN
cord-304876-txaoz7oh	71	41	the	the	DT
cord-304876-txaoz7oh	71	42	year	year	NN
cord-304876-txaoz7oh	71	43	.	.	.
cord-304876-txaoz7oh	72	1	Patterns	pattern	NNS
cord-304876-txaoz7oh	72	2	of	of	IN
cord-304876-txaoz7oh	72	3	seasonal	seasonal	JJ
cord-304876-txaoz7oh	72	4	irregularity	irregularity	NN
cord-304876-txaoz7oh	72	5	like	like	IN
cord-304876-txaoz7oh	72	6	this	this	DT
cord-304876-txaoz7oh	72	7	have	have	VBP
cord-304876-txaoz7oh	72	8	been	be	VBN
cord-304876-txaoz7oh	72	9	noted	note	VBN
cord-304876-txaoz7oh	72	10	with	with	IN
cord-304876-txaoz7oh	72	11	other	other	JJ
cord-304876-txaoz7oh	72	12	respiratory	respiratory	JJ
cord-304876-txaoz7oh	72	13	viruses	virus	NNS
cord-304876-txaoz7oh	72	14	,	,	,
cord-304876-txaoz7oh	72	15	particularly	particularly	RB
cord-304876-txaoz7oh	72	16	RSV	RSV	NNP
cord-304876-txaoz7oh	72	17	and	and	CC
cord-304876-txaoz7oh	72	18	influenza	influenza	NN
cord-304876-txaoz7oh	72	19	.	.	.
cord-304876-txaoz7oh	73	1	24	24	CD
cord-304876-txaoz7oh	73	2	 	 	_SP
cord-304876-txaoz7oh	73	3	Rhinoviruses	Rhinoviruses	NNP
cord-304876-txaoz7oh	73	4	are	be	VBP
cord-304876-txaoz7oh	73	5	thought	think	VBN
cord-304876-txaoz7oh	73	6	to	to	TO
cord-304876-txaoz7oh	73	7	be	be	VB
cord-304876-txaoz7oh	73	8	the	the	DT
cord-304876-txaoz7oh	73	9	cause	cause	NN
cord-304876-txaoz7oh	73	10	of	of	IN
cord-304876-txaoz7oh	73	11	up	up	IN
cord-304876-txaoz7oh	73	12	to	to	IN
cord-304876-txaoz7oh	73	13	twothirds	twothird	NNS
cord-304876-txaoz7oh	73	14	of	of	IN
cord-304876-txaoz7oh	73	15	what	what	WP
cord-304876-txaoz7oh	73	16	is	be	VBZ
cord-304876-txaoz7oh	73	17	termed	term	VBN
cord-304876-txaoz7oh	73	18	the	the	DT
cord-304876-txaoz7oh	73	19	common	common	JJ
cord-304876-txaoz7oh	73	20	cold	cold	NN
cord-304876-txaoz7oh	73	21	,	,	,
cord-304876-txaoz7oh	73	22	worldwide	worldwide	RB
cord-304876-txaoz7oh	73	23	.	.	.
cord-304876-txaoz7oh	74	1	Children	child	NNS
cord-304876-txaoz7oh	74	2	tend	tend	VBP
cord-304876-txaoz7oh	74	3	to	to	TO
cord-304876-txaoz7oh	74	4	experience	experience	VB
cord-304876-txaoz7oh	74	5	up	up	IN
cord-304876-txaoz7oh	74	6	to	to	TO
cord-304876-txaoz7oh	74	7	12	12	CD
cord-304876-txaoz7oh	74	8	of	of	IN
cord-304876-txaoz7oh	74	9	these	these	DT
cord-304876-txaoz7oh	74	10	infections	infection	NNS
cord-304876-txaoz7oh	74	11	,	,	,
cord-304876-txaoz7oh	74	12	or	or	CC
cord-304876-txaoz7oh	74	13	colds	cold	NNS
cord-304876-txaoz7oh	74	14	,	,	,
cord-304876-txaoz7oh	74	15	per	per	IN
cord-304876-txaoz7oh	74	16	year	year	NN
cord-304876-txaoz7oh	74	17	,	,	,
cord-304876-txaoz7oh	74	18	while	while	IN
cord-304876-txaoz7oh	74	19	this	this	DT
cord-304876-txaoz7oh	74	20	incidence	incidence	NN
cord-304876-txaoz7oh	74	21	drops	drop	VBZ
cord-304876-txaoz7oh	74	22	in	in	IN
cord-304876-txaoz7oh	74	23	adults	adult	NNS
cord-304876-txaoz7oh	74	24	to	to	IN
cord-304876-txaoz7oh	74	25	just	just	RB
cord-304876-txaoz7oh	74	26	2	2	CD
cord-304876-txaoz7oh	74	27	-	-	SYM
cord-304876-txaoz7oh	74	28	3	3	CD
cord-304876-txaoz7oh	74	29	per	per	IN
cord-304876-txaoz7oh	74	30	year	year	NN
cord-304876-txaoz7oh	74	31	.	.	.
cord-304876-txaoz7oh	75	1	25	25	CD
cord-304876-txaoz7oh	75	2	There	there	EX
cord-304876-txaoz7oh	75	3	are	be	VBP
cord-304876-txaoz7oh	75	4	three	three	CD
cord-304876-txaoz7oh	75	5	distinct	distinct	JJ
cord-304876-txaoz7oh	75	6	species	specie	NNS
cord-304876-txaoz7oh	75	7	of	of	IN
cord-304876-txaoz7oh	75	8	rhinovirus	rhinovirus	NN
cord-304876-txaoz7oh	75	9	,	,	,
cord-304876-txaoz7oh	75	10	RV	RV	NNP
cord-304876-txaoz7oh	75	11	-	-	HYPH
cord-304876-txaoz7oh	75	12	A	A	NNP
cord-304876-txaoz7oh	75	13	,	,	,
cord-304876-txaoz7oh	75	14	RV	rv	NN
cord-304876-txaoz7oh	75	15	-	-	HYPH
cord-304876-txaoz7oh	75	16	B	B	NNP
cord-304876-txaoz7oh	75	17	,	,	,
cord-304876-txaoz7oh	75	18	and	and	CC
cord-304876-txaoz7oh	75	19	RV	RV	NNP
cord-304876-txaoz7oh	75	20	-	-	HYPH
cord-304876-txaoz7oh	75	21	C	C	NNP
cord-304876-txaoz7oh	75	22	,	,	,
cord-304876-txaoz7oh	75	23	each	each	DT
cord-304876-txaoz7oh	75	24	of	of	IN
cord-304876-txaoz7oh	75	25	which	which	WDT
cord-304876-txaoz7oh	75	26	infects	infect	VBZ
cord-304876-txaoz7oh	75	27	humans	human	NNS
cord-304876-txaoz7oh	75	28	at	at	IN
cord-304876-txaoz7oh	75	29	different	different	JJ
cord-304876-txaoz7oh	75	30	periods	period	NNS
cord-304876-txaoz7oh	75	31	throughout	throughout	IN
cord-304876-txaoz7oh	75	32	the	the	DT
cord-304876-txaoz7oh	75	33	year	year	NN
cord-304876-txaoz7oh	75	34	.	.	.
cord-304876-txaoz7oh	76	1	26	26	CD
cord-304876-txaoz7oh	76	2	Symptoms	symptom	NNS
cord-304876-txaoz7oh	76	3	include	include	VBP
cord-304876-txaoz7oh	76	4	cough	cough	NN
cord-304876-txaoz7oh	76	5	,	,	,
cord-304876-txaoz7oh	76	6	fever	fever	NN
cord-304876-txaoz7oh	76	7	,	,	,
cord-304876-txaoz7oh	76	8	sneezing	sneezing	NN
cord-304876-txaoz7oh	76	9	,	,	,
cord-304876-txaoz7oh	76	10	nasal	nasal	NN
cord-304876-txaoz7oh	76	11	congestion	congestion	NN
cord-304876-txaoz7oh	76	12	,	,	,
cord-304876-txaoz7oh	76	13	sore	sore	JJ
cord-304876-txaoz7oh	76	14	throat	throat	NN
cord-304876-txaoz7oh	76	15	,	,	,
cord-304876-txaoz7oh	76	16	fever	fever	NN
cord-304876-txaoz7oh	76	17	,	,	,
cord-304876-txaoz7oh	76	18	and	and	CC
cord-304876-txaoz7oh	76	19	headache	headache	NN
cord-304876-txaoz7oh	76	20	and	and	CC
cord-304876-txaoz7oh	76	21	usually	usually	RB
cord-304876-txaoz7oh	76	22	last	last	JJ
cord-304876-txaoz7oh	76	23	7	7	CD
cord-304876-txaoz7oh	76	24	-	-	SYM
cord-304876-txaoz7oh	76	25	10	10	CD
cord-304876-txaoz7oh	76	26	days	day	NNS
cord-304876-txaoz7oh	76	27	after	after	IN
cord-304876-txaoz7oh	76	28	an	an	DT
cord-304876-txaoz7oh	76	29	initial	initial	JJ
cord-304876-txaoz7oh	76	30	48-h	48-h	CD
cord-304876-txaoz7oh	76	31	viral	viral	JJ
cord-304876-txaoz7oh	76	32	incubation	incubation	NN
cord-304876-txaoz7oh	76	33	.	.	.
cord-304876-txaoz7oh	77	1	27	27	CD
cord-304876-txaoz7oh	78	1	In	in	IN
cord-304876-txaoz7oh	78	2	addition	addition	NN
cord-304876-txaoz7oh	78	3	to	to	IN
cord-304876-txaoz7oh	78	4	the	the	DT
cord-304876-txaoz7oh	78	5	three	three	CD
cord-304876-txaoz7oh	78	6	rhinoviruses	rhinovirus	NNS
cord-304876-txaoz7oh	78	7	,	,	,
cord-304876-txaoz7oh	78	8	four	four	CD
cord-304876-txaoz7oh	78	9	enterovirus	enterovirus	NN
cord-304876-txaoz7oh	78	10	species	specie	NNS
cord-304876-txaoz7oh	78	11	result	result	VBP
cord-304876-txaoz7oh	78	12	in	in	IN
cord-304876-txaoz7oh	78	13	disease	disease	NN
cord-304876-txaoz7oh	78	14	in	in	IN
cord-304876-txaoz7oh	78	15	humans	human	NNS
cord-304876-txaoz7oh	78	16	,	,	,
cord-304876-txaoz7oh	78	17	EV	EV	NNP
cord-304876-txaoz7oh	78	18	-	-	HYPH
cord-304876-txaoz7oh	78	19	A	A	NNP
cord-304876-txaoz7oh	78	20	,	,	,
cord-304876-txaoz7oh	78	21	EV	ev	NN
cord-304876-txaoz7oh	78	22	-	-	HYPH
cord-304876-txaoz7oh	78	23	B	B	NNP
cord-304876-txaoz7oh	78	24	,	,	,
cord-304876-txaoz7oh	78	25	EV	EV	NNP
cord-304876-txaoz7oh	78	26	-	-	HYPH
cord-304876-txaoz7oh	78	27	C	C	NNP
cord-304876-txaoz7oh	78	28	,	,	,
cord-304876-txaoz7oh	78	29	and	and	CC
cord-304876-txaoz7oh	78	30	EV	ev	NN
cord-304876-txaoz7oh	78	31	-	-	HYPH
cord-304876-txaoz7oh	78	32	D	D	NNP
cord-304876-txaoz7oh	78	33	,	,	,
cord-304876-txaoz7oh	78	34	while	while	IN
cord-304876-txaoz7oh	78	35	EV	ev	NN
cord-304876-txaoz7oh	78	36	-	-	HYPH
cord-304876-txaoz7oh	78	37	E	e	NN
cord-304876-txaoz7oh	78	38	through	through	IN
cord-304876-txaoz7oh	78	39	EV	ev	NN
cord-304876-txaoz7oh	78	40	-	-	HYPH
cord-304876-txaoz7oh	78	41	H	H	NNP
cord-304876-txaoz7oh	78	42	,	,	,
cord-304876-txaoz7oh	78	43	and	and	CC
cord-304876-txaoz7oh	78	44	EV	EV	NNP
cord-304876-txaoz7oh	78	45	-	-	HYPH
cord-304876-txaoz7oh	78	46	J	J	NNP
cord-304876-txaoz7oh	78	47	affect	affect	VBP
cord-304876-txaoz7oh	78	48	non	non	JJ
cord-304876-txaoz7oh	78	49	-	-	JJ
cord-304876-txaoz7oh	78	50	human	human	JJ
cord-304876-txaoz7oh	78	51	hosts	host	NNS
cord-304876-txaoz7oh	78	52	.	.	.
cord-304876-txaoz7oh	79	1	28	28	CD
cord-304876-txaoz7oh	80	1	,	,	,
cord-304876-txaoz7oh	80	2	29	29	CD
cord-304876-txaoz7oh	80	3	Enteroviruses	enterovirus	NNS
cord-304876-txaoz7oh	80	4	differ	differ	VBP
cord-304876-txaoz7oh	80	5	from	from	IN
cord-304876-txaoz7oh	80	6	rhinoviruses	rhinovirus	NNS
cord-304876-txaoz7oh	80	7	in	in	IN
cord-304876-txaoz7oh	80	8	that	that	DT
cord-304876-txaoz7oh	80	9	while	while	IN
cord-304876-txaoz7oh	80	10	rhinoviruses	rhinovirus	NNS
cord-304876-txaoz7oh	80	11	are	be	VBP
cord-304876-txaoz7oh	80	12	limited	limit	VBN
cord-304876-txaoz7oh	80	13	to	to	IN
cord-304876-txaoz7oh	80	14	the	the	DT
cord-304876-txaoz7oh	80	15	respiratory	respiratory	JJ
cord-304876-txaoz7oh	80	16	airways	airway	NNS
cord-304876-txaoz7oh	80	17	,	,	,
cord-304876-txaoz7oh	80	18	enteroviruses	enterovirus	NNS
cord-304876-txaoz7oh	80	19	infect	infect	VBP
cord-304876-txaoz7oh	80	20	a	a	DT
cord-304876-txaoz7oh	80	21	wide	wide	JJ
cord-304876-txaoz7oh	80	22	range	range	NN
cord-304876-txaoz7oh	80	23	of	of	IN
cord-304876-txaoz7oh	80	24	cell	cell	NN
cord-304876-txaoz7oh	80	25	types	type	NNS
cord-304876-txaoz7oh	80	26	.	.	.
cord-304876-txaoz7oh	81	1	They	-PRON-	PRP
cord-304876-txaoz7oh	81	2	result	result	VBP
cord-304876-txaoz7oh	81	3	in	in	IN
cord-304876-txaoz7oh	81	4	a	a	DT
cord-304876-txaoz7oh	81	5	large	large	JJ
cord-304876-txaoz7oh	81	6	array	array	NN
cord-304876-txaoz7oh	81	7	of	of	IN
cord-304876-txaoz7oh	81	8	complications	complication	NNS
cord-304876-txaoz7oh	81	9	associated	associate	VBN
cord-304876-txaoz7oh	81	10	with	with	IN
cord-304876-txaoz7oh	81	11	the	the	DT
cord-304876-txaoz7oh	81	12	respiratory	respiratory	JJ
cord-304876-txaoz7oh	81	13	,	,	,
cord-304876-txaoz7oh	81	14	gastrointestinal	gastrointestinal	JJ
cord-304876-txaoz7oh	81	15	,	,	,
cord-304876-txaoz7oh	81	16	and	and	CC
cord-304876-txaoz7oh	81	17	central	central	JJ
cord-304876-txaoz7oh	81	18	nervous	nervous	JJ
cord-304876-txaoz7oh	81	19	systems	system	NNS
cord-304876-txaoz7oh	81	20	.	.	.
cord-304876-txaoz7oh	82	1	Manifestations	manifestation	NNS
cord-304876-txaoz7oh	82	2	of	of	IN
cord-304876-txaoz7oh	82	3	enterovirus	enterovirus	NN
cord-304876-txaoz7oh	82	4	infection	infection	NN
cord-304876-txaoz7oh	82	5	range	range	VBP
cord-304876-txaoz7oh	82	6	from	from	IN
cord-304876-txaoz7oh	82	7	a	a	DT
cord-304876-txaoz7oh	82	8	febrile	febrile	JJ
cord-304876-txaoz7oh	82	9	cold	cold	NN
cord-304876-txaoz7oh	82	10	to	to	IN
cord-304876-txaoz7oh	82	11	encephalitis	encephalitis	NN
cord-304876-txaoz7oh	82	12	,	,	,
cord-304876-txaoz7oh	82	13	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	82	14	,	,	,
cord-304876-txaoz7oh	82	15	viral	viral	JJ
cord-304876-txaoz7oh	82	16	meningitis	meningitis	NN
cord-304876-txaoz7oh	82	17	,	,	,
cord-304876-txaoz7oh	82	18	and	and	CC
cord-304876-txaoz7oh	82	19	even	even	RB
cord-304876-txaoz7oh	82	20	death	death	NN
cord-304876-txaoz7oh	82	21	.	.	.
cord-304876-txaoz7oh	83	1	30	30	CD
cord-304876-txaoz7oh	84	1	Although	although	IN
cord-304876-txaoz7oh	84	2	EV	EV	NNP
cord-304876-txaoz7oh	84	3	-	-	HYPH
cord-304876-txaoz7oh	84	4	C	C	NNP
cord-304876-txaoz7oh	84	5	and	and	CC
cord-304876-txaoz7oh	84	6	EV	ev	NN
cord-304876-txaoz7oh	84	7	-	-	HYPH
cord-304876-txaoz7oh	84	8	D	D	NNP
cord-304876-txaoz7oh	84	9	are	be	VBP
cord-304876-txaoz7oh	84	10	the	the	DT
cord-304876-txaoz7oh	84	11	principal	principal	JJ
cord-304876-txaoz7oh	84	12	enteroviruses	enterovirus	NNS
cord-304876-txaoz7oh	84	13	that	that	WDT
cord-304876-txaoz7oh	84	14	cause	cause	VBP
cord-304876-txaoz7oh	84	15	respiratory	respiratory	JJ
cord-304876-txaoz7oh	84	16	illness	illness	NN
cord-304876-txaoz7oh	84	17	,	,	,
cord-304876-txaoz7oh	84	18	EV	EV	NNP
cord-304876-txaoz7oh	84	19	-	-	HYPH
cord-304876-txaoz7oh	84	20	A	A	NNP
cord-304876-txaoz7oh	84	21	also	also	RB
cord-304876-txaoz7oh	84	22	includes	include	VBZ
cord-304876-txaoz7oh	84	23	EV71	EV71	NNP
cord-304876-txaoz7oh	84	24	.	.	.
cord-304876-txaoz7oh	85	1	EV71	EV71	NNP
cord-304876-txaoz7oh	85	2	causes	cause	VBZ
cord-304876-txaoz7oh	85	3	hand	hand	NN
cord-304876-txaoz7oh	85	4	-	-	HYPH
cord-304876-txaoz7oh	85	5	foot	foot	NN
cord-304876-txaoz7oh	85	6	-	-	HYPH
cord-304876-txaoz7oh	85	7	and	and	CC
cord-304876-txaoz7oh	85	8	-	-	HYPH
cord-304876-txaoz7oh	85	9	mouth	mouth	NN
cord-304876-txaoz7oh	85	10	disease	disease	NN
cord-304876-txaoz7oh	85	11	,	,	,
cord-304876-txaoz7oh	85	12	a	a	DT
cord-304876-txaoz7oh	85	13	highly	highly	RB
cord-304876-txaoz7oh	85	14	contagious	contagious	JJ
cord-304876-txaoz7oh	85	15	pathogen	pathogen	NN
cord-304876-txaoz7oh	85	16	in	in	IN
cord-304876-txaoz7oh	85	17	children	child	NNS
cord-304876-txaoz7oh	85	18	that	that	WDT
cord-304876-txaoz7oh	85	19	mainly	mainly	RB
cord-304876-txaoz7oh	85	20	results	result	VBZ
cord-304876-txaoz7oh	85	21	in	in	IN
cord-304876-txaoz7oh	85	22	a	a	DT
cord-304876-txaoz7oh	85	23	maculopapular	maculopapular	JJ
cord-304876-txaoz7oh	85	24	rash	rash	NN
cord-304876-txaoz7oh	85	25	,	,	,
cord-304876-txaoz7oh	85	26	blisters	blister	NNS
cord-304876-txaoz7oh	85	27	on	on	IN
cord-304876-txaoz7oh	85	28	the	the	DT
cord-304876-txaoz7oh	85	29	limbs	limb	NNS
cord-304876-txaoz7oh	85	30	,	,	,
cord-304876-txaoz7oh	85	31	and	and	CC
cord-304876-txaoz7oh	85	32	ulcers	ulcer	NNS
cord-304876-txaoz7oh	85	33	in	in	IN
cord-304876-txaoz7oh	85	34	the	the	DT
cord-304876-txaoz7oh	85	35	mouth	mouth	NN
cord-304876-txaoz7oh	85	36	.	.	.
cord-304876-txaoz7oh	86	1	31	31	CD
cord-304876-txaoz7oh	87	1	EV71	EV71	NNP
cord-304876-txaoz7oh	87	2	is	be	VBZ
cord-304876-txaoz7oh	87	3	most	most	RBS
cord-304876-txaoz7oh	87	4	prevalent	prevalent	JJ
cord-304876-txaoz7oh	87	5	in	in	IN
cord-304876-txaoz7oh	87	6	the	the	DT
cord-304876-txaoz7oh	87	7	summer	summer	NN
cord-304876-txaoz7oh	87	8	months	month	NNS
cord-304876-txaoz7oh	87	9	and	and	CC
cord-304876-txaoz7oh	87	10	tends	tend	VBZ
cord-304876-txaoz7oh	87	11	to	to	TO
cord-304876-txaoz7oh	87	12	be	be	VB
cord-304876-txaoz7oh	87	13	more	more	RBR
cord-304876-txaoz7oh	87	14	ubiquitous	ubiquitous	JJ
cord-304876-txaoz7oh	87	15	in	in	IN
cord-304876-txaoz7oh	87	16	tropical	tropical	JJ
cord-304876-txaoz7oh	87	17	zones	zone	NNS
cord-304876-txaoz7oh	87	18	of	of	IN
cord-304876-txaoz7oh	87	19	the	the	DT
cord-304876-txaoz7oh	87	20	globe	globe	NN
cord-304876-txaoz7oh	87	21	.	.	.
cord-304876-txaoz7oh	88	1	In	in	IN
cord-304876-txaoz7oh	88	2	rare	rare	JJ
cord-304876-txaoz7oh	88	3	cases	case	NNS
cord-304876-txaoz7oh	88	4	of	of	IN
cord-304876-txaoz7oh	88	5	severe	severe	JJ
cord-304876-txaoz7oh	88	6	EV71	EV71	NNP
cord-304876-txaoz7oh	88	7	infection	infection	NN
cord-304876-txaoz7oh	88	8	,	,	,
cord-304876-txaoz7oh	88	9	respiratory	respiratory	JJ
cord-304876-txaoz7oh	88	10	illness	illness	NN
cord-304876-txaoz7oh	88	11	can	can	MD
cord-304876-txaoz7oh	88	12	lead	lead	VB
cord-304876-txaoz7oh	88	13	to	to	IN
cord-304876-txaoz7oh	88	14	pulmonary	pulmonary	JJ
cord-304876-txaoz7oh	88	15	edema	edema	NN
cord-304876-txaoz7oh	88	16	,	,	,
cord-304876-txaoz7oh	88	17	hemorrhage	hemorrhage	NN
cord-304876-txaoz7oh	88	18	,	,	,
cord-304876-txaoz7oh	88	19	and	and	CC
cord-304876-txaoz7oh	88	20	lung	lung	NN
cord-304876-txaoz7oh	88	21	failure	failure	NN
cord-304876-txaoz7oh	88	22	.	.	.
cord-304876-txaoz7oh	89	1	32	32	CD
cord-304876-txaoz7oh	89	2	Presently	presently	RB
cord-304876-txaoz7oh	89	3	,	,	,
cord-304876-txaoz7oh	89	4	six	six	CD
cord-304876-txaoz7oh	89	5	HCoV	hcov	NN
cord-304876-txaoz7oh	89	6	are	be	VBP
cord-304876-txaoz7oh	89	7	recognized	recognize	VBN
cord-304876-txaoz7oh	89	8	:	:	:
cord-304876-txaoz7oh	89	9	HCoV-229E	HCoV-229E	NNP
cord-304876-txaoz7oh	89	10	,	,	,
cord-304876-txaoz7oh	89	11	HCoV	HCoV	NNP
cord-304876-txaoz7oh	89	12	-	-	HYPH
cord-304876-txaoz7oh	89	13	NL63	NL63	NNP
cord-304876-txaoz7oh	89	14	,	,	,
cord-304876-txaoz7oh	89	15	HCoV	HCoV	NNP
cord-304876-txaoz7oh	89	16	-	-	HYPH
cord-304876-txaoz7oh	89	17	OC43	OC43	NNP
cord-304876-txaoz7oh	89	18	,	,	,
cord-304876-txaoz7oh	89	19	HCoV	HCoV	NNP
cord-304876-txaoz7oh	89	20	-	-	HYPH
cord-304876-txaoz7oh	89	21	HKU1	HKU1	NNP
cord-304876-txaoz7oh	89	22	,	,	,
cord-304876-txaoz7oh	89	23	and	and	CC
cord-304876-txaoz7oh	89	24	the	the	DT
cord-304876-txaoz7oh	89	25	well	well	RB
cord-304876-txaoz7oh	89	26	-	-	HYPH
cord-304876-txaoz7oh	89	27	known	know	VBN
cord-304876-txaoz7oh	89	28	SARS	SARS	NNP
cord-304876-txaoz7oh	89	29	and	and	CC
cord-304876-txaoz7oh	89	30	MERS	MERS	NNP
cord-304876-txaoz7oh	90	1	CoV.	CoV.	NNP
cord-304876-txaoz7oh	90	2	33	33	CD
cord-304876-txaoz7oh	91	1	These	these	DT
cord-304876-txaoz7oh	91	2	CoV	cov	NN
cord-304876-txaoz7oh	91	3	can	can	MD
cord-304876-txaoz7oh	91	4	be	be	VB
cord-304876-txaoz7oh	91	5	further	further	RB
cord-304876-txaoz7oh	91	6	characterized	characterize	VBN
cord-304876-txaoz7oh	91	7	based	base	VBN
cord-304876-txaoz7oh	91	8	on	on	IN
cord-304876-txaoz7oh	91	9	genera	genus	NNS
cord-304876-txaoz7oh	91	10	of	of	IN
cord-304876-txaoz7oh	91	11	Alpha	alpha	NN
cord-304876-txaoz7oh	91	12	,	,	,
cord-304876-txaoz7oh	91	13	Beta	Beta	NNP
cord-304876-txaoz7oh	91	14	,	,	,
cord-304876-txaoz7oh	91	15	Gamma	Gamma	NNP
cord-304876-txaoz7oh	91	16	,	,	,
cord-304876-txaoz7oh	91	17	or	or	CC
cord-304876-txaoz7oh	91	18	Delta	Delta	NNP
cord-304876-txaoz7oh	91	19	;	;	:
cord-304876-txaoz7oh	91	20	the	the	DT
cord-304876-txaoz7oh	91	21	Alpha	alpha	NN
cord-304876-txaoz7oh	91	22	and	and	CC
cord-304876-txaoz7oh	91	23	Beta	Beta	NNP
cord-304876-txaoz7oh	91	24	CoV	cov	NN
cord-304876-txaoz7oh	91	25	comprise	comprise	VBP
cord-304876-txaoz7oh	91	26	the	the	DT
cord-304876-txaoz7oh	91	27	six	six	CD
cord-304876-txaoz7oh	91	28	viruses	virus	NNS
cord-304876-txaoz7oh	91	29	mentioned	mention	VBN
cord-304876-txaoz7oh	91	30	above	above	RB
cord-304876-txaoz7oh	91	31	,	,	,
cord-304876-txaoz7oh	91	32	and	and	CC
cord-304876-txaoz7oh	91	33	are	be	VBP
cord-304876-txaoz7oh	91	34	those	those	DT
cord-304876-txaoz7oh	91	35	that	that	WDT
cord-304876-txaoz7oh	91	36	infect	infect	VBP
cord-304876-txaoz7oh	91	37	humans	human	NNS
cord-304876-txaoz7oh	91	38	.	.	.
cord-304876-txaoz7oh	92	1	CoV	CoV	NNP
cord-304876-txaoz7oh	92	2	229E	229e	CD
cord-304876-txaoz7oh	92	3	and	and	CC
cord-304876-txaoz7oh	92	4	OC43	OC43	NNP
cord-304876-txaoz7oh	92	5	are	be	VBP
cord-304876-txaoz7oh	92	6	both	both	DT
cord-304876-txaoz7oh	92	7	pathogens	pathogen	NNS
cord-304876-txaoz7oh	92	8	associated	associate	VBN
cord-304876-txaoz7oh	92	9	with	with	IN
cord-304876-txaoz7oh	92	10	the	the	DT
cord-304876-txaoz7oh	92	11	common	common	JJ
cord-304876-txaoz7oh	92	12	cold	cold	NN
cord-304876-txaoz7oh	92	13	,	,	,
cord-304876-txaoz7oh	92	14	but	but	CC
cord-304876-txaoz7oh	92	15	can	can	MD
cord-304876-txaoz7oh	92	16	cause	cause	VB
cord-304876-txaoz7oh	92	17	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	92	18	as	as	RB
cord-304876-txaoz7oh	92	19	well	well	RB
cord-304876-txaoz7oh	92	20	.	.	.
cord-304876-txaoz7oh	93	1	34	34	CD
cord-304876-txaoz7oh	93	2	HCoV	HCoV	NNP
cord-304876-txaoz7oh	93	3	-	-	HYPH
cord-304876-txaoz7oh	93	4	NL63	NL63	NNP
cord-304876-txaoz7oh	93	5	and	and	CC
cord-304876-txaoz7oh	93	6	HCoV	HCoV	NNP
cord-304876-txaoz7oh	93	7	-	-	HYPH
cord-304876-txaoz7oh	93	8	HKU1	HKU1	NNP
cord-304876-txaoz7oh	93	9	infection	infection	NN
cord-304876-txaoz7oh	93	10	show	show	VBP
cord-304876-txaoz7oh	93	11	similar	similar	JJ
cord-304876-txaoz7oh	93	12	clinical	clinical	JJ
cord-304876-txaoz7oh	93	13	features	feature	NNS
cord-304876-txaoz7oh	93	14	to	to	IN
cord-304876-txaoz7oh	93	15	those	those	DT
cord-304876-txaoz7oh	93	16	in	in	IN
cord-304876-txaoz7oh	93	17	patients	patient	NNS
cord-304876-txaoz7oh	93	18	with	with	IN
cord-304876-txaoz7oh	93	19	229E	229e	CD
cord-304876-txaoz7oh	93	20	and	and	CC
cord-304876-txaoz7oh	93	21	OC43	OC43	NNP
cord-304876-txaoz7oh	93	22	,	,	,
cord-304876-txaoz7oh	93	23	but	but	CC
cord-304876-txaoz7oh	93	24	clinicians	clinician	NNS
cord-304876-txaoz7oh	93	25	have	have	VBP
cord-304876-txaoz7oh	93	26	also	also	RB
cord-304876-txaoz7oh	93	27	reported	report	VBN
cord-304876-txaoz7oh	93	28	bronchiolitis	bronchiolitis	NN
cord-304876-txaoz7oh	93	29	,	,	,
cord-304876-txaoz7oh	93	30	croup	croup	NN
cord-304876-txaoz7oh	93	31	,	,	,
cord-304876-txaoz7oh	93	32	and	and	CC
cord-304876-txaoz7oh	93	33	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	93	34	in	in	IN
cord-304876-txaoz7oh	93	35	infected	infected	JJ
cord-304876-txaoz7oh	93	36	individuals	individual	NNS
cord-304876-txaoz7oh	93	37	.	.	.
cord-304876-txaoz7oh	94	1	35	35	CD
cord-304876-txaoz7oh	94	2	,	,	,
cord-304876-txaoz7oh	94	3	36	36	CD
cord-304876-txaoz7oh	95	1	The	the	DT
cord-304876-txaoz7oh	95	2	first	first	JJ
cord-304876-txaoz7oh	95	3	CoV	cov	NN
cord-304876-txaoz7oh	95	4	recognized	recognize	VBN
cord-304876-txaoz7oh	95	5	as	as	IN
cord-304876-txaoz7oh	95	6	pandemic	pandemic	JJ
cord-304876-txaoz7oh	95	7	threat	threat	NN
cord-304876-txaoz7oh	95	8	is	be	VBZ
cord-304876-txaoz7oh	96	1	SARS	SARS	NNP
cord-304876-txaoz7oh	96	2	-	-	HYPH
cord-304876-txaoz7oh	96	3	CoV.	CoV.	NNP
cord-304876-txaoz7oh	96	4	SARS	SARS	NNP
cord-304876-txaoz7oh	96	5	was	be	VBD
cord-304876-txaoz7oh	96	6	discovered	discover	VBN
cord-304876-txaoz7oh	96	7	in	in	IN
cord-304876-txaoz7oh	96	8	2002	2002	CD
cord-304876-txaoz7oh	96	9	-	-	SYM
cord-304876-txaoz7oh	96	10	2003	2003	CD
cord-304876-txaoz7oh	96	11	after	after	IN
cord-304876-txaoz7oh	96	12	a	a	DT
cord-304876-txaoz7oh	96	13	perplexing	perplexing	JJ
cord-304876-txaoz7oh	96	14	epidemic	epidemic	NN
cord-304876-txaoz7oh	96	15	of	of	IN
cord-304876-txaoz7oh	96	16	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	96	17	among	among	IN
cord-304876-txaoz7oh	96	18	hospital	hospital	NN
cord-304876-txaoz7oh	96	19	workers	worker	NNS
cord-304876-txaoz7oh	96	20	in	in	IN
cord-304876-txaoz7oh	96	21	China	China	NNP
cord-304876-txaoz7oh	96	22	.	.	.
cord-304876-txaoz7oh	97	1	37	37	CD
cord-304876-txaoz7oh	98	1	By	by	IN
cord-304876-txaoz7oh	98	2	the	the	DT
cord-304876-txaoz7oh	98	3	end	end	NN
cord-304876-txaoz7oh	98	4	of	of	IN
cord-304876-txaoz7oh	98	5	its	-PRON-	PRP$
cord-304876-txaoz7oh	98	6	global	global	JJ
cord-304876-txaoz7oh	98	7	epidemic	epidemic	NN
cord-304876-txaoz7oh	98	8	,	,	,
cord-304876-txaoz7oh	98	9	SARS	SARS	NNP
cord-304876-txaoz7oh	98	10	disseminated	disseminate	VBD
cord-304876-txaoz7oh	98	11	to	to	IN
cord-304876-txaoz7oh	98	12	29	29	CD
cord-304876-txaoz7oh	98	13	countries	country	NNS
cord-304876-txaoz7oh	98	14	,	,	,
cord-304876-txaoz7oh	98	15	infecting	infect	VBG
cord-304876-txaoz7oh	98	16	over	over	IN
cord-304876-txaoz7oh	98	17	8000	8000	CD
cord-304876-txaoz7oh	98	18	individuals	individual	NNS
cord-304876-txaoz7oh	98	19	,	,	,
cord-304876-txaoz7oh	98	20	and	and	CC
cord-304876-txaoz7oh	98	21	killing	kill	VBG
cord-304876-txaoz7oh	98	22	roughly	roughly	RB
cord-304876-txaoz7oh	98	23	10	10	CD
cord-304876-txaoz7oh	98	24	%	%	NN
cord-304876-txaoz7oh	98	25	of	of	IN
cord-304876-txaoz7oh	98	26	those	those	DT
cord-304876-txaoz7oh	98	27	infected	infect	VBN
cord-304876-txaoz7oh	98	28	.	.	.
cord-304876-txaoz7oh	99	1	38	38	CD
cord-304876-txaoz7oh	99	2	Roughly	roughly	RB
cord-304876-txaoz7oh	99	3	a	a	DT
cord-304876-txaoz7oh	99	4	decade	decade	NN
cord-304876-txaoz7oh	99	5	later	later	RB
cord-304876-txaoz7oh	99	6	,	,	,
cord-304876-txaoz7oh	99	7	a	a	DT
cord-304876-txaoz7oh	99	8	similar	similar	JJ
cord-304876-txaoz7oh	99	9	pattern	pattern	NN
cord-304876-txaoz7oh	99	10	occurred	occur	VBD
cord-304876-txaoz7oh	99	11	with	with	IN
cord-304876-txaoz7oh	99	12	MERS	MERS	NNP
cord-304876-txaoz7oh	99	13	,	,	,
cord-304876-txaoz7oh	99	14	which	which	WDT
cord-304876-txaoz7oh	99	15	began	begin	VBD
cord-304876-txaoz7oh	99	16	in	in	IN
cord-304876-txaoz7oh	99	17	2012	2012	CD
cord-304876-txaoz7oh	99	18	in	in	IN
cord-304876-txaoz7oh	99	19	Jordan	Jordan	NNP
cord-304876-txaoz7oh	99	20	with	with	IN
cord-304876-txaoz7oh	99	21	an	an	DT
cord-304876-txaoz7oh	99	22	outbreak	outbreak	NN
cord-304876-txaoz7oh	99	23	of	of	IN
cord-304876-txaoz7oh	99	24	a	a	DT
cord-304876-txaoz7oh	99	25	respiratory	respiratory	JJ
cord-304876-txaoz7oh	99	26	illness	illness	NN
cord-304876-txaoz7oh	99	27	among	among	IN
cord-304876-txaoz7oh	99	28	hospital	hospital	NN
cord-304876-txaoz7oh	99	29	workers	worker	NNS
cord-304876-txaoz7oh	99	30	,	,	,
cord-304876-txaoz7oh	99	31	one	one	CD
cord-304876-txaoz7oh	99	32	of	of	IN
cord-304876-txaoz7oh	99	33	whom	whom	WP
cord-304876-txaoz7oh	99	34	died	die	VBD
cord-304876-txaoz7oh	99	35	of	of	IN
cord-304876-txaoz7oh	99	36	the	the	DT
cord-304876-txaoz7oh	99	37	infection	infection	NN
cord-304876-txaoz7oh	99	38	.	.	.
cord-304876-txaoz7oh	100	1	Later	later	RB
cord-304876-txaoz7oh	100	2	that	that	DT
cord-304876-txaoz7oh	100	3	year	year	NN
cord-304876-txaoz7oh	100	4	,	,	,
cord-304876-txaoz7oh	100	5	a	a	DT
cord-304876-txaoz7oh	100	6	man	man	NN
cord-304876-txaoz7oh	100	7	with	with	IN
cord-304876-txaoz7oh	100	8	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	100	9	and	and	CC
cord-304876-txaoz7oh	100	10	multiple	multiple	JJ
cord-304876-txaoz7oh	100	11	organ	organ	NN
cord-304876-txaoz7oh	100	12	failure	failure	NN
cord-304876-txaoz7oh	100	13	in	in	IN
cord-304876-txaoz7oh	100	14	Saudi	Saudi	NNP
cord-304876-txaoz7oh	100	15	Arabia	Arabia	NNP
cord-304876-txaoz7oh	100	16	was	be	VBD
cord-304876-txaoz7oh	100	17	found	find	VBN
cord-304876-txaoz7oh	100	18	to	to	TO
cord-304876-txaoz7oh	100	19	have	have	VB
cord-304876-txaoz7oh	100	20	the	the	DT
cord-304876-txaoz7oh	100	21	MERS	MERS	NNP
cord-304876-txaoz7oh	100	22	pathogen	pathogen	NN
cord-304876-txaoz7oh	100	23	.	.	.
cord-304876-txaoz7oh	101	1	39	39	CD
cord-304876-txaoz7oh	101	2	Adults	Adults	NNPS
cord-304876-txaoz7oh	101	3	are	be	VBP
cord-304876-txaoz7oh	101	4	the	the	DT
cord-304876-txaoz7oh	101	5	target	target	NN
cord-304876-txaoz7oh	101	6	population	population	NN
cord-304876-txaoz7oh	101	7	for	for	IN
cord-304876-txaoz7oh	101	8	both	both	CC
cord-304876-txaoz7oh	101	9	SARS	SARS	NNP
cord-304876-txaoz7oh	101	10	and	and	CC
cord-304876-txaoz7oh	101	11	MERS	MERS	NNPS
cord-304876-txaoz7oh	101	12	with	with	IN
cord-304876-txaoz7oh	101	13	a	a	DT
cord-304876-txaoz7oh	101	14	median	median	JJ
cord-304876-txaoz7oh	101	15	age	age	NN
cord-304876-txaoz7oh	101	16	range	range	NN
cord-304876-txaoz7oh	101	17	of	of	IN
cord-304876-txaoz7oh	101	18	39	39	CD
cord-304876-txaoz7oh	101	19	-	-	SYM
cord-304876-txaoz7oh	101	20	50	50	CD
cord-304876-txaoz7oh	101	21	years	year	NNS
cord-304876-txaoz7oh	101	22	;	;	:
cord-304876-txaoz7oh	101	23	MERS	MERS	NNP
cord-304876-txaoz7oh	101	24	occurs	occur	VBZ
cord-304876-txaoz7oh	101	25	predominantly	predominantly	RB
cord-304876-txaoz7oh	101	26	in	in	IN
cord-304876-txaoz7oh	101	27	men	man	NNS
cord-304876-txaoz7oh	101	28	whereas	whereas	IN
cord-304876-txaoz7oh	101	29	SARS	SARS	NNP
cord-304876-txaoz7oh	101	30	does	do	VBZ
cord-304876-txaoz7oh	101	31	not	not	RB
cord-304876-txaoz7oh	101	32	.	.	.
cord-304876-txaoz7oh	102	1	The	the	DT
cord-304876-txaoz7oh	102	2	clinical	clinical	JJ
cord-304876-txaoz7oh	102	3	features	feature	NNS
cord-304876-txaoz7oh	102	4	of	of	IN
cord-304876-txaoz7oh	102	5	both	both	DT
cord-304876-txaoz7oh	102	6	SARS	SARS	NNP
cord-304876-txaoz7oh	102	7	and	and	CC
cord-304876-txaoz7oh	102	8	MERS	MERS	NNP
cord-304876-txaoz7oh	102	9	range	range	VBP
cord-304876-txaoz7oh	102	10	from	from	IN
cord-304876-txaoz7oh	102	11	mild	mild	JJ
cord-304876-txaoz7oh	102	12	to	to	IN
cord-304876-txaoz7oh	102	13	severe	severe	JJ
cord-304876-txaoz7oh	102	14	respiratory	respiratory	JJ
cord-304876-txaoz7oh	102	15	illness	illness	NN
cord-304876-txaoz7oh	102	16	,	,	,
cord-304876-txaoz7oh	102	17	fever	fever	NN
cord-304876-txaoz7oh	102	18	,	,	,
cord-304876-txaoz7oh	102	19	chills	chill	NNS
cord-304876-txaoz7oh	102	20	,	,	,
cord-304876-txaoz7oh	102	21	cough	cough	NN
cord-304876-txaoz7oh	102	22	,	,	,
cord-304876-txaoz7oh	102	23	shortness	shortness	NN
cord-304876-txaoz7oh	102	24	of	of	IN
cord-304876-txaoz7oh	102	25	breath	breath	NN
cord-304876-txaoz7oh	102	26	,	,	,
cord-304876-txaoz7oh	102	27	vomiting	vomit	VBG
cord-304876-txaoz7oh	102	28	,	,	,
cord-304876-txaoz7oh	102	29	and	and	CC
cord-304876-txaoz7oh	102	30	diarrhea	diarrhea	NN
cord-304876-txaoz7oh	102	31	,	,	,
cord-304876-txaoz7oh	102	32	with	with	IN
cord-304876-txaoz7oh	102	33	the	the	DT
cord-304876-txaoz7oh	102	34	latter	latter	JJ
cord-304876-txaoz7oh	102	35	displaying	display	VBG
cord-304876-txaoz7oh	102	36	a	a	DT
cord-304876-txaoz7oh	102	37	more	more	RBR
cord-304876-txaoz7oh	102	38	lethal	lethal	JJ
cord-304876-txaoz7oh	102	39	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	102	40	and	and	CC
cord-304876-txaoz7oh	102	41	renal	renal	JJ
cord-304876-txaoz7oh	102	42	failure	failure	NN
cord-304876-txaoz7oh	102	43	.	.	.
cord-304876-txaoz7oh	103	1	40	40	CD
cord-304876-txaoz7oh	103	2	,	,	,
cord-304876-txaoz7oh	103	3	41	41	CD
cord-304876-txaoz7oh	104	1	Even	even	RB
cord-304876-txaoz7oh	104	2	worse	bad	JJR
cord-304876-txaoz7oh	104	3	than	than	IN
cord-304876-txaoz7oh	104	4	SARS	SARS	NNP
cord-304876-txaoz7oh	104	5	mortality	mortality	NN
cord-304876-txaoz7oh	104	6	,	,	,
cord-304876-txaoz7oh	104	7	retrospective	retrospective	JJ
cord-304876-txaoz7oh	104	8	analysis	analysis	NN
cord-304876-txaoz7oh	104	9	has	have	VBZ
cord-304876-txaoz7oh	104	10	shown	show	VBN
cord-304876-txaoz7oh	104	11	that	that	DT
cord-304876-txaoz7oh	104	12	of	of	IN
cord-304876-txaoz7oh	104	13	the	the	DT
cord-304876-txaoz7oh	104	14	2040	2040	CD
cord-304876-txaoz7oh	104	15	confirmed	confirm	VBD
cord-304876-txaoz7oh	104	16	cases	case	NNS
cord-304876-txaoz7oh	104	17	of	of	IN
cord-304876-txaoz7oh	104	18	MERS	MERS	NNP
cord-304876-txaoz7oh	104	19	,	,	,
cord-304876-txaoz7oh	104	20	35	35	CD
cord-304876-txaoz7oh	104	21	%	%	NN
cord-304876-txaoz7oh	104	22	were	be	VBD
cord-304876-txaoz7oh	104	23	fatal	fatal	JJ
cord-304876-txaoz7oh	104	24	.	.	.
cord-304876-txaoz7oh	105	1	42	42	CD
cord-304876-txaoz7oh	105	2	Viral	viral	JJ
cord-304876-txaoz7oh	105	3	polymerase	polymerase	NN
cord-304876-txaoz7oh	105	4	:	:	:
cord-304876-txaoz7oh	105	5	An	an	DT
cord-304876-txaoz7oh	105	6	important	important	JJ
cord-304876-txaoz7oh	105	7	molecular	molecular	JJ
cord-304876-txaoz7oh	105	8	target	target	NN
cord-304876-txaoz7oh	105	9	for	for	IN
cord-304876-txaoz7oh	105	10	antiviral	antiviral	JJ
cord-304876-txaoz7oh	105	11	therapy	therapy	NN
cord-304876-txaoz7oh	105	12	Nucleoside	Nucleoside	NNP
cord-304876-txaoz7oh	105	13	analogs	analog	NNS
cord-304876-txaoz7oh	105	14	represent	represent	VBP
cord-304876-txaoz7oh	105	15	one	one	CD
cord-304876-txaoz7oh	105	16	of	of	IN
cord-304876-txaoz7oh	105	17	the	the	DT
cord-304876-txaoz7oh	105	18	dominant	dominant	JJ
cord-304876-txaoz7oh	105	19	classes	class	NNS
cord-304876-txaoz7oh	105	20	of	of	IN
cord-304876-txaoz7oh	105	21	antiviral	antiviral	JJ
cord-304876-txaoz7oh	105	22	agents	agent	NNS
cord-304876-txaoz7oh	105	23	due	due	JJ
cord-304876-txaoz7oh	105	24	to	to	IN
cord-304876-txaoz7oh	105	25	their	-PRON-	PRP$
cord-304876-txaoz7oh	105	26	widespread	widespread	JJ
cord-304876-txaoz7oh	105	27	use	use	NN
cord-304876-txaoz7oh	105	28	against	against	IN
cord-304876-txaoz7oh	105	29	the	the	DT
cord-304876-txaoz7oh	105	30	common	common	JJ
cord-304876-txaoz7oh	105	31	chronic	chronic	JJ
cord-304876-txaoz7oh	105	32	infections	infection	NNS
cord-304876-txaoz7oh	105	33	caused	cause	VBN
cord-304876-txaoz7oh	105	34	by	by	IN
cord-304876-txaoz7oh	105	35	human	human	JJ
cord-304876-txaoz7oh	105	36	immunodeficiency	immunodeficiency	NN
cord-304876-txaoz7oh	105	37	virus	virus	NN
cord-304876-txaoz7oh	105	38	(	(	-LRB-
cord-304876-txaoz7oh	105	39	HIV	HIV	NNP
cord-304876-txaoz7oh	105	40	)	)	-RRB-
cord-304876-txaoz7oh	105	41	,	,	,
cord-304876-txaoz7oh	105	42	hepatitis	hepatitis	NNP
cord-304876-txaoz7oh	105	43	B	B	NNP
cord-304876-txaoz7oh	105	44	virus	virus	NN
cord-304876-txaoz7oh	105	45	,	,	,
cord-304876-txaoz7oh	105	46	and	and	CC
cord-304876-txaoz7oh	105	47	herpesviruses	herpesviruses	NNP
cord-304876-txaoz7oh	105	48	.	.	.
cord-304876-txaoz7oh	106	1	In	in	IN
cord-304876-txaoz7oh	106	2	the	the	DT
cord-304876-txaoz7oh	106	3	past	past	JJ
cord-304876-txaoz7oh	106	4	15	15	CD
cord-304876-txaoz7oh	106	5	years	year	NNS
cord-304876-txaoz7oh	106	6	,	,	,
cord-304876-txaoz7oh	106	7	multiple	multiple	JJ
cord-304876-txaoz7oh	106	8	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	106	9	and	and	CC
cord-304876-txaoz7oh	106	10	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	106	11	analogs	analog	NNS
cord-304876-txaoz7oh	106	12	have	have	VBP
cord-304876-txaoz7oh	106	13	been	be	VBN
cord-304876-txaoz7oh	106	14	developed	develop	VBN
cord-304876-txaoz7oh	106	15	as	as	IN
cord-304876-txaoz7oh	106	16	direct	direct	JJ
cord-304876-txaoz7oh	106	17	-	-	HYPH
cord-304876-txaoz7oh	106	18	acting	act	VBG
cord-304876-txaoz7oh	106	19	agents	agent	NNS
cord-304876-txaoz7oh	106	20	against	against	IN
cord-304876-txaoz7oh	106	21	RNA	RNA	NNP
cord-304876-txaoz7oh	106	22	virus	virus	NN
cord-304876-txaoz7oh	106	23	infections	infection	NNS
cord-304876-txaoz7oh	106	24	such	such	JJ
cord-304876-txaoz7oh	106	25	as	as	IN
cord-304876-txaoz7oh	106	26	hepatitis	hepatitis	NN
cord-304876-txaoz7oh	106	27	C	C	NNP
cord-304876-txaoz7oh	106	28	virus	virus	NN
cord-304876-txaoz7oh	106	29	(	(	-LRB-
cord-304876-txaoz7oh	106	30	HCV	HCV	NNP
cord-304876-txaoz7oh	106	31	)	)	-RRB-
cord-304876-txaoz7oh	106	32	,	,	,
cord-304876-txaoz7oh	106	33	but	but	CC
cord-304876-txaoz7oh	106	34	have	have	VBP
cord-304876-txaoz7oh	106	35	not	not	RB
cord-304876-txaoz7oh	106	36	yet	yet	RB
cord-304876-txaoz7oh	106	37	been	be	VBN
cord-304876-txaoz7oh	106	38	successfully	successfully	RB
cord-304876-txaoz7oh	106	39	applied	apply	VBN
cord-304876-txaoz7oh	106	40	to	to	IN
cord-304876-txaoz7oh	106	41	acute	acute	JJ
cord-304876-txaoz7oh	106	42	infections	infection	NNS
cord-304876-txaoz7oh	106	43	caused	cause	VBN
cord-304876-txaoz7oh	106	44	by	by	IN
cord-304876-txaoz7oh	106	45	respiratory	respiratory	JJ
cord-304876-txaoz7oh	106	46	viruses	virus	NNS
cord-304876-txaoz7oh	106	47	.	.	.
cord-304876-txaoz7oh	107	1	Only	only	RB
cord-304876-txaoz7oh	107	2	a	a	DT
cord-304876-txaoz7oh	107	3	handful	handful	NN
cord-304876-txaoz7oh	107	4	of	of	IN
cord-304876-txaoz7oh	107	5	nonnucleoside	nonnucleoside	JJ
cord-304876-txaoz7oh	107	6	drugs	drug	NNS
cord-304876-txaoz7oh	107	7	have	have	VBP
cord-304876-txaoz7oh	107	8	been	be	VBN
cord-304876-txaoz7oh	107	9	developed	develop	VBN
cord-304876-txaoz7oh	107	10	for	for	IN
cord-304876-txaoz7oh	107	11	the	the	DT
cord-304876-txaoz7oh	107	12	treatment	treatment	NN
cord-304876-txaoz7oh	107	13	and	and	CC
cord-304876-txaoz7oh	107	14	prevention	prevention	NN
cord-304876-txaoz7oh	107	15	of	of	IN
cord-304876-txaoz7oh	107	16	these	these	DT
cord-304876-txaoz7oh	107	17	viruses	virus	NNS
cord-304876-txaoz7oh	107	18	.	.	.
cord-304876-txaoz7oh	108	1	Such	such	JJ
cord-304876-txaoz7oh	108	2	drugs	drug	NNS
cord-304876-txaoz7oh	108	3	include	include	VBP
cord-304876-txaoz7oh	108	4	the	the	DT
cord-304876-txaoz7oh	108	5	FDA	FDA	NNP
cord-304876-txaoz7oh	108	6	approved	approve	VBD
cord-304876-txaoz7oh	108	7	oseltamivir	oseltamivir	NNP
cord-304876-txaoz7oh	108	8	,	,	,
cord-304876-txaoz7oh	108	9	zanamivir	zanamivir	NNP
cord-304876-txaoz7oh	108	10	,	,	,
cord-304876-txaoz7oh	108	11	and	and	CC
cord-304876-txaoz7oh	108	12	peramivir	peramivir	NNPS
cord-304876-txaoz7oh	108	13	for	for	IN
cord-304876-txaoz7oh	108	14	influenza	influenza	NN
cord-304876-txaoz7oh	108	15	virus	virus	NN
cord-304876-txaoz7oh	108	16	infection	infection	NN
cord-304876-txaoz7oh	108	17	,	,	,
cord-304876-txaoz7oh	108	18	palivizumab	palivizumab	NNS
cord-304876-txaoz7oh	108	19	for	for	IN
cord-304876-txaoz7oh	108	20	RSV	RSV	NNP
cord-304876-txaoz7oh	108	21	prevention	prevention	NN
cord-304876-txaoz7oh	108	22	,	,	,
cord-304876-txaoz7oh	108	23	as	as	RB
cord-304876-txaoz7oh	108	24	well	well	RB
cord-304876-txaoz7oh	108	25	as	as	IN
cord-304876-txaoz7oh	108	26	the	the	DT
cord-304876-txaoz7oh	108	27	two	two	CD
cord-304876-txaoz7oh	108	28	discontinued	discontinue	VBD
cord-304876-txaoz7oh	108	29	clinical	clinical	JJ
cord-304876-txaoz7oh	108	30	candidates	candidate	NNS
cord-304876-txaoz7oh	108	31	targeting	target	VBG
cord-304876-txaoz7oh	108	32	rhinovirus	rhinovirus	NN
cord-304876-txaoz7oh	108	33	,	,	,
cord-304876-txaoz7oh	108	34	pleconaril	pleconaril	NNP
cord-304876-txaoz7oh	108	35	and	and	CC
cord-304876-txaoz7oh	108	36	rupintrivir	rupintrivir	NNP
cord-304876-txaoz7oh	108	37	.	.	.
cord-304876-txaoz7oh	109	1	These	these	DT
cord-304876-txaoz7oh	109	2	molecules	molecule	NNS
cord-304876-txaoz7oh	109	3	possess	possess	VBP
cord-304876-txaoz7oh	109	4	limitations	limitation	NNS
cord-304876-txaoz7oh	109	5	preventing	prevent	VBG
cord-304876-txaoz7oh	109	6	their	-PRON-	PRP$
cord-304876-txaoz7oh	109	7	widespread	widespread	JJ
cord-304876-txaoz7oh	109	8	use	use	NN
cord-304876-txaoz7oh	109	9	,	,	,
cord-304876-txaoz7oh	109	10	such	such	JJ
cord-304876-txaoz7oh	109	11	as	as	IN
cord-304876-txaoz7oh	109	12	short	short	JJ
cord-304876-txaoz7oh	109	13	therapeutic	therapeutic	JJ
cord-304876-txaoz7oh	109	14	window	window	NN
cord-304876-txaoz7oh	109	15	and	and	CC
cord-304876-txaoz7oh	109	16	risk	risk	NN
cord-304876-txaoz7oh	109	17	of	of	IN
cord-304876-txaoz7oh	109	18	resistance	resistance	NN
cord-304876-txaoz7oh	109	19	selection	selection	NN
cord-304876-txaoz7oh	109	20	for	for	IN
cord-304876-txaoz7oh	109	21	the	the	DT
cord-304876-txaoz7oh	109	22	neuraminidase	neuraminidase	NN
cord-304876-txaoz7oh	109	23	inhibitors	inhibitor	NNS
cord-304876-txaoz7oh	109	24	,	,	,
cord-304876-txaoz7oh	109	25	and	and	CC
cord-304876-txaoz7oh	109	26	only	only	JJ
cord-304876-txaoz7oh	109	27	partial	partial	JJ
cord-304876-txaoz7oh	109	28	protection	protection	NN
cord-304876-txaoz7oh	109	29	associated	associate	VBN
cord-304876-txaoz7oh	109	30	with	with	IN
cord-304876-txaoz7oh	109	31	prophylactic	prophylactic	JJ
cord-304876-txaoz7oh	109	32	use	use	NN
cord-304876-txaoz7oh	109	33	for	for	IN
cord-304876-txaoz7oh	109	34	palivizumab	palivizumab	NNS
cord-304876-txaoz7oh	109	35	.	.	.
cord-304876-txaoz7oh	110	1	This	this	DT
cord-304876-txaoz7oh	110	2	has	have	VBZ
cord-304876-txaoz7oh	110	3	provided	provide	VBN
cord-304876-txaoz7oh	110	4	the	the	DT
cord-304876-txaoz7oh	110	5	impetus	impetus	NN
cord-304876-txaoz7oh	110	6	for	for	IN
cord-304876-txaoz7oh	110	7	the	the	DT
cord-304876-txaoz7oh	110	8	approval	approval	NN
cord-304876-txaoz7oh	110	9	of	of	IN
cord-304876-txaoz7oh	110	10	new	new	JJ
cord-304876-txaoz7oh	110	11	drugs	drug	NNS
cord-304876-txaoz7oh	110	12	with	with	IN
cord-304876-txaoz7oh	110	13	a	a	DT
cord-304876-txaoz7oh	110	14	broader	broader	RBR
cord-304876-txaoz7oh	110	15	therapeutic	therapeutic	JJ
cord-304876-txaoz7oh	110	16	use	use	NN
cord-304876-txaoz7oh	110	17	.	.	.
cord-304876-txaoz7oh	111	1	The	the	DT
cord-304876-txaoz7oh	111	2	recognized	recognize	VBN
cord-304876-txaoz7oh	111	3	advantages	advantage	NNS
cord-304876-txaoz7oh	111	4	of	of	IN
cord-304876-txaoz7oh	111	5	direct	direct	JJ
cord-304876-txaoz7oh	111	6	-	-	HYPH
cord-304876-txaoz7oh	111	7	acting	act	VBG
cord-304876-txaoz7oh	111	8	agent	agent	NN
cord-304876-txaoz7oh	111	9	nucleosides	nucleoside	VBZ
cord-304876-txaoz7oh	111	10	over	over	IN
cord-304876-txaoz7oh	111	11	other	other	JJ
cord-304876-txaoz7oh	111	12	classes	class	NNS
cord-304876-txaoz7oh	111	13	of	of	IN
cord-304876-txaoz7oh	111	14	antiviral	antiviral	JJ
cord-304876-txaoz7oh	111	15	agents	agent	NNS
cord-304876-txaoz7oh	111	16	are	be	VBP
cord-304876-txaoz7oh	111	17	(	(	-LRB-
cord-304876-txaoz7oh	111	18	1	1	LS
cord-304876-txaoz7oh	111	19	)	)	-RRB-
cord-304876-txaoz7oh	111	20	their	-PRON-	PRP$
cord-304876-txaoz7oh	111	21	propensity	propensity	NN
cord-304876-txaoz7oh	111	22	to	to	TO
cord-304876-txaoz7oh	111	23	cover	cover	VB
cord-304876-txaoz7oh	111	24	a	a	DT
cord-304876-txaoz7oh	111	25	broad	broad	JJ
cord-304876-txaoz7oh	111	26	-	-	HYPH
cord-304876-txaoz7oh	111	27	spectrum	spectrum	NN
cord-304876-txaoz7oh	111	28	of	of	IN
cord-304876-txaoz7oh	111	29	virus	virus	NN
cord-304876-txaoz7oh	111	30	strains	strain	NNS
cord-304876-txaoz7oh	111	31	and	and	CC
cord-304876-txaoz7oh	111	32	sometimes	sometimes	RB
cord-304876-txaoz7oh	111	33	species	specie	NNS
cord-304876-txaoz7oh	111	34	and	and	CC
cord-304876-txaoz7oh	111	35	(	(	-LRB-
cord-304876-txaoz7oh	111	36	2	2	LS
cord-304876-txaoz7oh	111	37	)	)	-RRB-
cord-304876-txaoz7oh	111	38	their	-PRON-	PRP$
cord-304876-txaoz7oh	111	39	high	high	JJ
cord-304876-txaoz7oh	111	40	barrier	barrier	NN
cord-304876-txaoz7oh	111	41	to	to	IN
cord-304876-txaoz7oh	111	42	antiviral	antiviral	JJ
cord-304876-txaoz7oh	111	43	resistance	resistance	NN
cord-304876-txaoz7oh	111	44	.	.	.
cord-304876-txaoz7oh	112	1	Both	both	DT
cord-304876-txaoz7oh	112	2	properties	property	NNS
cord-304876-txaoz7oh	112	3	are	be	VBP
cord-304876-txaoz7oh	112	4	best	best	RB
cord-304876-txaoz7oh	112	5	explained	explain	VBN
cord-304876-txaoz7oh	112	6	by	by	IN
cord-304876-txaoz7oh	112	7	the	the	DT
cord-304876-txaoz7oh	112	8	mechanism	mechanism	NN
cord-304876-txaoz7oh	112	9	of	of	IN
cord-304876-txaoz7oh	112	10	action	action	NN
cord-304876-txaoz7oh	112	11	common	common	JJ
cord-304876-txaoz7oh	112	12	to	to	IN
cord-304876-txaoz7oh	112	13	most	most	JJS
cord-304876-txaoz7oh	112	14	antiviral	antiviral	JJ
cord-304876-txaoz7oh	112	15	nucleosides	nucleoside	NNS
cord-304876-txaoz7oh	112	16	:	:	:
cord-304876-txaoz7oh	112	17	targeting	target	VBG
cord-304876-txaoz7oh	112	18	viral	viral	JJ
cord-304876-txaoz7oh	112	19	polymerases	polymerase	NNS
cord-304876-txaoz7oh	112	20	.	.	.
cord-304876-txaoz7oh	113	1	43	43	CD
cord-304876-txaoz7oh	113	2	After	after	IN
cord-304876-txaoz7oh	113	3	being	be	VBG
cord-304876-txaoz7oh	113	4	metabolized	metabolize	VBN
cord-304876-txaoz7oh	113	5	by	by	IN
cord-304876-txaoz7oh	113	6	host	host	NN
cord-304876-txaoz7oh	113	7	kinases	kinase	NNS
cord-304876-txaoz7oh	113	8	to	to	IN
cord-304876-txaoz7oh	113	9	their	-PRON-	PRP$
cord-304876-txaoz7oh	113	10	triphosphate	triphosphate	NN
cord-304876-txaoz7oh	113	11	form	form	NN
cord-304876-txaoz7oh	113	12	,	,	,
cord-304876-txaoz7oh	113	13	antiviral	antiviral	JJ
cord-304876-txaoz7oh	113	14	nucleotides	nucleotide	NNS
cord-304876-txaoz7oh	113	15	compete	compete	VBP
cord-304876-txaoz7oh	113	16	with	with	IN
cord-304876-txaoz7oh	113	17	natural	natural	JJ
cord-304876-txaoz7oh	113	18	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	113	19	triphosphates	triphosphate	NNS
cord-304876-txaoz7oh	113	20	(	(	-LRB-
cord-304876-txaoz7oh	113	21	NTPs	ntp	NNS
cord-304876-txaoz7oh	113	22	)	)	-RRB-
cord-304876-txaoz7oh	113	23	to	to	TO
cord-304876-txaoz7oh	113	24	bind	bind	VB
cord-304876-txaoz7oh	113	25	to	to	IN
cord-304876-txaoz7oh	113	26	the	the	DT
cord-304876-txaoz7oh	113	27	active	active	JJ
cord-304876-txaoz7oh	113	28	site	site	NN
cord-304876-txaoz7oh	113	29	of	of	IN
cord-304876-txaoz7oh	113	30	viral	viral	JJ
cord-304876-txaoz7oh	113	31	polymerases	polymerase	NNS
cord-304876-txaoz7oh	113	32	and	and	CC
cord-304876-txaoz7oh	113	33	alter	alter	VB
cord-304876-txaoz7oh	113	34	DNA	DNA	NNP
cord-304876-txaoz7oh	113	35	or	or	CC
cord-304876-txaoz7oh	113	36	RNA	RNA	NNP
cord-304876-txaoz7oh	113	37	synthesis	synthesis	NN
cord-304876-txaoz7oh	113	38	.	.	.
cord-304876-txaoz7oh	114	1	The	the	DT
cord-304876-txaoz7oh	114	2	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	114	3	binding	bind	VBG
cord-304876-txaoz7oh	114	4	site	site	NN
cord-304876-txaoz7oh	114	5	of	of	IN
cord-304876-txaoz7oh	114	6	these	these	DT
cord-304876-txaoz7oh	114	7	proteins	protein	NNS
cord-304876-txaoz7oh	114	8	is	be	VBZ
cord-304876-txaoz7oh	114	9	usually	usually	RB
cord-304876-txaoz7oh	114	10	well	well	RB
cord-304876-txaoz7oh	114	11	conserved	conserve	VBN
cord-304876-txaoz7oh	114	12	among	among	IN
cord-304876-txaoz7oh	114	13	virus	virus	NN
cord-304876-txaoz7oh	114	14	families	family	NNS
cord-304876-txaoz7oh	114	15	and	and	CC
cord-304876-txaoz7oh	114	16	any	any	DT
cord-304876-txaoz7oh	114	17	changes	change	NNS
cord-304876-txaoz7oh	114	18	in	in	IN
cord-304876-txaoz7oh	114	19	neighboring	neighbor	VBG
cord-304876-txaoz7oh	114	20	amino	amino	NN
cord-304876-txaoz7oh	114	21	acids	acid	NNS
cord-304876-txaoz7oh	115	1	often	often	RB
cord-304876-txaoz7oh	115	2	comes	come	VBZ
cord-304876-txaoz7oh	115	3	at	at	IN
cord-304876-txaoz7oh	115	4	a	a	DT
cord-304876-txaoz7oh	115	5	cost	cost	NN
cord-304876-txaoz7oh	115	6	for	for	IN
cord-304876-txaoz7oh	115	7	the	the	DT
cord-304876-txaoz7oh	115	8	enzyme	enzyme	NN
cord-304876-txaoz7oh	115	9	and	and	CC
cord-304876-txaoz7oh	115	10	the	the	DT
cord-304876-txaoz7oh	115	11	virus	virus	NN
cord-304876-txaoz7oh	115	12	.	.	.
cord-304876-txaoz7oh	116	1	The	the	DT
cord-304876-txaoz7oh	116	2	functional	functional	JJ
cord-304876-txaoz7oh	116	3	and	and	CC
cord-304876-txaoz7oh	116	4	structural	structural	JJ
cord-304876-txaoz7oh	116	5	features	feature	NNS
cord-304876-txaoz7oh	116	6	of	of	IN
cord-304876-txaoz7oh	116	7	RNA	RNA	NNP
cord-304876-txaoz7oh	116	8	polymerases	polymerase	NNS
cord-304876-txaoz7oh	116	9	of	of	IN
cord-304876-txaoz7oh	116	10	respiratory	respiratory	JJ
cord-304876-txaoz7oh	116	11	viruses	virus	NNS
cord-304876-txaoz7oh	116	12	targeted	target	VBN
cord-304876-txaoz7oh	116	13	by	by	IN
cord-304876-txaoz7oh	116	14	antiviral	antiviral	JJ
cord-304876-txaoz7oh	116	15	nucleosides	nucleoside	NNS
cord-304876-txaoz7oh	116	16	are	be	VBP
cord-304876-txaoz7oh	116	17	described	describe	VBN
cord-304876-txaoz7oh	116	18	in	in	IN
cord-304876-txaoz7oh	116	19	the	the	DT
cord-304876-txaoz7oh	116	20	following	following	JJ
cord-304876-txaoz7oh	116	21	paragraphs	paragraph	NNS
cord-304876-txaoz7oh	116	22	.	.	.
cord-304876-txaoz7oh	117	1	Influenza	influenza	NN
cord-304876-txaoz7oh	117	2	virus	virus	NN
cord-304876-txaoz7oh	117	3	is	be	VBZ
cord-304876-txaoz7oh	117	4	a	a	DT
cord-304876-txaoz7oh	117	5	(	(	-LRB-
cord-304876-txaoz7oh	117	6	-)ssRNA	-)ssRNA	NNP
cord-304876-txaoz7oh	117	7	virus	virus	NN
cord-304876-txaoz7oh	117	8	and	and	CC
cord-304876-txaoz7oh	117	9	a	a	DT
cord-304876-txaoz7oh	117	10	member	member	NN
cord-304876-txaoz7oh	117	11	of	of	IN
cord-304876-txaoz7oh	117	12	the	the	DT
cord-304876-txaoz7oh	117	13	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-304876-txaoz7oh	117	14	family	family	NN
cord-304876-txaoz7oh	117	15	.	.	.
cord-304876-txaoz7oh	118	1	5	5	LS
cord-304876-txaoz7oh	119	1	The	the	DT
cord-304876-txaoz7oh	119	2	viral	viral	JJ
cord-304876-txaoz7oh	119	3	genome	genome	NN
cord-304876-txaoz7oh	119	4	has	have	VBZ
cord-304876-txaoz7oh	119	5	eight	eight	CD
cord-304876-txaoz7oh	119	6	segments	segment	NNS
cord-304876-txaoz7oh	119	7	in	in	IN
cord-304876-txaoz7oh	119	8	influenza	influenza	NN
cord-304876-txaoz7oh	119	9	A	a	NN
cord-304876-txaoz7oh	119	10	and	and	CC
cord-304876-txaoz7oh	119	11	B	b	NN
cord-304876-txaoz7oh	119	12	and	and	CC
cord-304876-txaoz7oh	119	13	seven	seven	CD
cord-304876-txaoz7oh	119	14	segments	segment	NNS
cord-304876-txaoz7oh	119	15	in	in	IN
cord-304876-txaoz7oh	119	16	influenza	influenza	NN
cord-304876-txaoz7oh	119	17	C	C	NNP
cord-304876-txaoz7oh	119	18	and	and	CC
cord-304876-txaoz7oh	119	19	D.	D.	NNP
cord-304876-txaoz7oh	120	1	In	in	IN
cord-304876-txaoz7oh	120	2	influenza	influenza	NN
cord-304876-txaoz7oh	120	3	A	A	NNP
cord-304876-txaoz7oh	120	4	,	,	,
cord-304876-txaoz7oh	120	5	these	these	DT
cord-304876-txaoz7oh	120	6	encode	encode	VBP
cord-304876-txaoz7oh	120	7	for	for	IN
cord-304876-txaoz7oh	120	8	11	11	CD
cord-304876-txaoz7oh	120	9	or	or	CC
cord-304876-txaoz7oh	120	10	12	12	CD
cord-304876-txaoz7oh	120	11	proteins	protein	NNS
cord-304876-txaoz7oh	120	12	.	.	.
cord-304876-txaoz7oh	121	1	These	these	DT
cord-304876-txaoz7oh	121	2	are	be	VBP
cord-304876-txaoz7oh	121	3	non	non	JJ
cord-304876-txaoz7oh	121	4	-	-	JJ
cord-304876-txaoz7oh	121	5	structural	structural	JJ
cord-304876-txaoz7oh	121	6	protein	protein	NN
cord-304876-txaoz7oh	121	7	1	1	CD
cord-304876-txaoz7oh	121	8	(	(	-LRB-
cord-304876-txaoz7oh	121	9	NS1	ns1	CD
cord-304876-txaoz7oh	121	10	)	)	-RRB-
cord-304876-txaoz7oh	121	11	,	,	,
cord-304876-txaoz7oh	121	12	non	non	JJ
cord-304876-txaoz7oh	121	13	-	-	JJ
cord-304876-txaoz7oh	121	14	structural	structural	JJ
cord-304876-txaoz7oh	121	15	protein	protein	NN
cord-304876-txaoz7oh	121	16	2	2	CD
cord-304876-txaoz7oh	121	17	(	(	-LRB-
cord-304876-txaoz7oh	121	18	NS2	NS2	NNP
cord-304876-txaoz7oh	121	19	)	)	-RRB-
cord-304876-txaoz7oh	121	20	,	,	,
cord-304876-txaoz7oh	121	21	matrix	matrix	NN
cord-304876-txaoz7oh	121	22	protein	protein	NN
cord-304876-txaoz7oh	121	23	M1	M1	NNP
cord-304876-txaoz7oh	121	24	and	and	CC
cord-304876-txaoz7oh	121	25	ion	ion	NN
cord-304876-txaoz7oh	121	26	channel	channel	NNP
cord-304876-txaoz7oh	121	27	protein	protein	NN
cord-304876-txaoz7oh	121	28	M2	M2	NNP
cord-304876-txaoz7oh	121	29	,	,	,
cord-304876-txaoz7oh	121	30	polymerase	polymerase	VBP
cord-304876-txaoz7oh	121	31	acidic	acidic	JJ
cord-304876-txaoz7oh	121	32	(	(	-LRB-
cord-304876-txaoz7oh	121	33	PA	PA	NNP
cord-304876-txaoz7oh	121	34	)	)	-RRB-
cord-304876-txaoz7oh	121	35	protein	protein	NN
cord-304876-txaoz7oh	121	36	,	,	.
cord-304876-txaoz7oh	122	1	polymerase	polymerase	VB
cord-304876-txaoz7oh	122	2	basic	basic	JJ
cord-304876-txaoz7oh	122	3	protein	protein	NNP
cord-304876-txaoz7oh	122	4	(	(	-LRB-
cord-304876-txaoz7oh	122	5	PB1	PB1	NNP
cord-304876-txaoz7oh	122	6	)	)	-RRB-
cord-304876-txaoz7oh	122	7	,	,	.
cord-304876-txaoz7oh	123	1	polymerase	polymerase	NNP
cord-304876-txaoz7oh	123	2	basic	basic	JJ
cord-304876-txaoz7oh	123	3	protein	protein	NN
cord-304876-txaoz7oh	123	4	1-F2	1-f2	CD
cord-304876-txaoz7oh	123	5	,	,	,
cord-304876-txaoz7oh	123	6	polymerase	polymerase	VB
cord-304876-txaoz7oh	123	7	basic	basic	JJ
cord-304876-txaoz7oh	123	8	protein	protein	NN
cord-304876-txaoz7oh	123	9	2	2	CD
cord-304876-txaoz7oh	123	10	(	(	-LRB-
cord-304876-txaoz7oh	123	11	PB2	PB2	NNP
cord-304876-txaoz7oh	123	12	)	)	-RRB-
cord-304876-txaoz7oh	123	13	,	,	,
cord-304876-txaoz7oh	123	14	nucleoprotein	nucleoprotein	NNP
cord-304876-txaoz7oh	123	15	(	(	-LRB-
cord-304876-txaoz7oh	123	16	NP	NP	NNP
cord-304876-txaoz7oh	123	17	)	)	-RRB-
cord-304876-txaoz7oh	123	18	,	,	,
cord-304876-txaoz7oh	123	19	hemagglutinin	hemagglutinin	FW
cord-304876-txaoz7oh	123	20	(	(	-LRB-
cord-304876-txaoz7oh	123	21	HA	HA	NNP
cord-304876-txaoz7oh	123	22	)	)	-RRB-
cord-304876-txaoz7oh	123	23	,	,	,
cord-304876-txaoz7oh	123	24	and	and	CC
cord-304876-txaoz7oh	123	25	neuraminidase	neuraminidase	NN
cord-304876-txaoz7oh	123	26	(	(	-LRB-
cord-304876-txaoz7oh	123	27	NA	NA	NNP
cord-304876-txaoz7oh	123	28	)	)	-RRB-
cord-304876-txaoz7oh	123	29	.	.	.
cord-304876-txaoz7oh	124	1	44	44	CD
cord-304876-txaoz7oh	125	1	Some	some	DT
cord-304876-txaoz7oh	125	2	viruses	virus	NNS
cord-304876-txaoz7oh	125	3	express	express	VBP
cord-304876-txaoz7oh	125	4	the	the	DT
cord-304876-txaoz7oh	125	5	PB1-N40	PB1-N40	NNP
cord-304876-txaoz7oh	125	6	protein	protein	NN
cord-304876-txaoz7oh	125	7	.	.	.
cord-304876-txaoz7oh	126	1	All	all	DT
cord-304876-txaoz7oh	126	2	four	four	CD
cord-304876-txaoz7oh	126	3	species	specie	NNS
cord-304876-txaoz7oh	126	4	of	of	IN
cord-304876-txaoz7oh	126	5	influenza	influenza	NN
cord-304876-txaoz7oh	126	6	adopt	adopt	VB
cord-304876-txaoz7oh	126	7	similar	similar	JJ
cord-304876-txaoz7oh	126	8	arrangements	arrangement	NNS
cord-304876-txaoz7oh	126	9	with	with	IN
cord-304876-txaoz7oh	126	10	the	the	DT
cord-304876-txaoz7oh	126	11	viral	viral	JJ
cord-304876-txaoz7oh	126	12	genomic	genomic	JJ
cord-304876-txaoz7oh	126	13	segments	segment	NNS
cord-304876-txaoz7oh	126	14	forming	form	VBG
cord-304876-txaoz7oh	126	15	viral	viral	JJ
cord-304876-txaoz7oh	126	16	ribonucleoprotein	ribonucleoprotein	NN
cord-304876-txaoz7oh	126	17	complexes	complex	NNS
cord-304876-txaoz7oh	126	18	associated	associate	VBN
cord-304876-txaoz7oh	126	19	with	with	IN
cord-304876-txaoz7oh	126	20	one	one	CD
cord-304876-txaoz7oh	126	21	heterotrimeric	heterotrimeric	NN
cord-304876-txaoz7oh	126	22	polymerase	polymerase	NN
cord-304876-txaoz7oh	126	23	.	.	.
cord-304876-txaoz7oh	127	1	Influenza	Influenza	NNP
cord-304876-txaoz7oh	127	2	A	a	DT
cord-304876-txaoz7oh	127	3	polymerase	polymerase	NN
cord-304876-txaoz7oh	127	4	is	be	VBZ
cord-304876-txaoz7oh	127	5	composed	compose	VBN
cord-304876-txaoz7oh	127	6	of	of	IN
cord-304876-txaoz7oh	127	7	three	three	CD
cord-304876-txaoz7oh	127	8	subunits	subunit	NNS
cord-304876-txaoz7oh	127	9	that	that	WDT
cord-304876-txaoz7oh	127	10	yield	yield	VBP
cord-304876-txaoz7oh	127	11	a	a	DT
cord-304876-txaoz7oh	127	12	270	270	CD
cord-304876-txaoz7oh	127	13	kDa	kDa	NNP
cord-304876-txaoz7oh	127	14	heterotrimeric	heterotrimeric	NN
cord-304876-txaoz7oh	127	15	complex	complex	NN
cord-304876-txaoz7oh	127	16	.	.	.
cord-304876-txaoz7oh	128	1	The	the	DT
cord-304876-txaoz7oh	128	2	longest	long	JJS
cord-304876-txaoz7oh	128	3	viral	viral	JJ
cord-304876-txaoz7oh	128	4	RNA	rna	NN
cord-304876-txaoz7oh	128	5	segments	segment	NNS
cord-304876-txaoz7oh	128	6	encode	encode	VBP
cord-304876-txaoz7oh	128	7	for	for	IN
cord-304876-txaoz7oh	128	8	the	the	DT
cord-304876-txaoz7oh	128	9	PA	PA	NNP
cord-304876-txaoz7oh	128	10	protein	protein	NN
cord-304876-txaoz7oh	128	11	,	,	,
cord-304876-txaoz7oh	128	12	PB1	PB1	NNP
cord-304876-txaoz7oh	128	13	,	,	,
cord-304876-txaoz7oh	128	14	and	and	CC
cord-304876-txaoz7oh	128	15	PB2	PB2	NNP
cord-304876-txaoz7oh	128	16	,	,	,
cord-304876-txaoz7oh	128	17	which	which	WDT
cord-304876-txaoz7oh	128	18	assemble	assemble	VBP
cord-304876-txaoz7oh	128	19	to	to	TO
cord-304876-txaoz7oh	128	20	form	form	VB
cord-304876-txaoz7oh	128	21	the	the	DT
cord-304876-txaoz7oh	128	22	influenza	influenza	NN
cord-304876-txaoz7oh	128	23	polymerase	polymerase	NN
cord-304876-txaoz7oh	128	24	complex	complex	NN
cord-304876-txaoz7oh	128	25	(	(	-LRB-
cord-304876-txaoz7oh	128	26	see	see	VB
cord-304876-txaoz7oh	128	27	Figure	figure	NN
cord-304876-txaoz7oh	128	28	2	2	CD
cord-304876-txaoz7oh	128	29	)	)	-RRB-
cord-304876-txaoz7oh	128	30	.	.	.
cord-304876-txaoz7oh	129	1	45	45	CD
cord-304876-txaoz7oh	130	1	The	the	DT
cord-304876-txaoz7oh	130	2	three	three	CD
cord-304876-txaoz7oh	130	3	subunits	subunit	NNS
cord-304876-txaoz7oh	130	4	interact	interact	VBP
cord-304876-txaoz7oh	130	5	noncovalently	noncovalently	RB
cord-304876-txaoz7oh	130	6	to	to	TO
cord-304876-txaoz7oh	130	7	exert	exert	VB
cord-304876-txaoz7oh	130	8	their	-PRON-	PRP$
cord-304876-txaoz7oh	130	9	polymerase	polymerase	NN
cord-304876-txaoz7oh	130	10	activity	activity	NN
cord-304876-txaoz7oh	130	11	.	.	.
cord-304876-txaoz7oh	131	1	The	the	DT
cord-304876-txaoz7oh	131	2	polymerase	polymerase	NN
cord-304876-txaoz7oh	131	3	transcribes	transcribe	VBZ
cord-304876-txaoz7oh	131	4	viral	viral	JJ
cord-304876-txaoz7oh	131	5	RNA	RNA	NNP
cord-304876-txaoz7oh	131	6	into	into	IN
cord-304876-txaoz7oh	131	7	messenger	messenger	NN
cord-304876-txaoz7oh	131	8	RNA	RNA	NNP
cord-304876-txaoz7oh	131	9	(	(	-LRB-
cord-304876-txaoz7oh	131	10	mRNA	mRNA	NNP
cord-304876-txaoz7oh	131	11	)	)	-RRB-
cord-304876-txaoz7oh	131	12	and	and	CC
cord-304876-txaoz7oh	131	13	then	then	RB
cord-304876-txaoz7oh	131	14	replicates	replicate	VBZ
cord-304876-txaoz7oh	131	15	it	-PRON-	PRP
cord-304876-txaoz7oh	131	16	using	use	VBG
cord-304876-txaoz7oh	131	17	a	a	DT
cord-304876-txaoz7oh	131	18	complementary	complementary	JJ
cord-304876-txaoz7oh	131	19	RNA	RNA	NNP
cord-304876-txaoz7oh	131	20	intermediate	intermediate	JJ
cord-304876-txaoz7oh	131	21	.	.	.
cord-304876-txaoz7oh	132	1	5	5	LS
cord-304876-txaoz7oh	133	1	The	the	DT
cord-304876-txaoz7oh	133	2	process	process	NN
cord-304876-txaoz7oh	133	3	of	of	IN
cord-304876-txaoz7oh	133	4	transcription	transcription	NN
cord-304876-txaoz7oh	133	5	includes	include	VBZ
cord-304876-txaoz7oh	133	6	cap	cap	NN
cord-304876-txaoz7oh	133	7	snatching	snatching	NN
cord-304876-txaoz7oh	133	8	,	,	,
cord-304876-txaoz7oh	133	9	where	where	WRB
cord-304876-txaoz7oh	133	10	short	short	RB
cord-304876-txaoz7oh	133	11	-	-	HYPH
cord-304876-txaoz7oh	133	12	capped	cap	VBN
cord-304876-txaoz7oh	133	13	cellular	cellular	JJ
cord-304876-txaoz7oh	133	14	RNA	RNA	NNP
cord-304876-txaoz7oh	133	15	are	be	VBP
cord-304876-txaoz7oh	133	16	bound	bind	VBN
cord-304876-txaoz7oh	133	17	by	by	IN
cord-304876-txaoz7oh	133	18	the	the	DT
cord-304876-txaoz7oh	133	19	PB2	PB2	NNP
cord-304876-txaoz7oh	133	20	subunit	subunit	NN
cord-304876-txaoz7oh	133	21	,	,	,
cord-304876-txaoz7oh	133	22	cleaved	cleave	VBN
cord-304876-txaoz7oh	133	23	from	from	IN
cord-304876-txaoz7oh	133	24	the	the	DT
cord-304876-txaoz7oh	133	25	PA	PA	NNP
cord-304876-txaoz7oh	133	26	endonuclease	endonuclease	NN
cord-304876-txaoz7oh	133	27	domain	domain	NN
cord-304876-txaoz7oh	133	28	,	,	,
cord-304876-txaoz7oh	133	29	and	and	CC
cord-304876-txaoz7oh	133	30	then	then	RB
cord-304876-txaoz7oh	133	31	utilized	utilize	VBN
cord-304876-txaoz7oh	133	32	for	for	IN
cord-304876-txaoz7oh	133	33	priming	prime	VBG
cord-304876-txaoz7oh	133	34	mRNA	mRNA	NNP
cord-304876-txaoz7oh	133	35	synthesis	synthesis	NN
cord-304876-txaoz7oh	133	36	by	by	IN
cord-304876-txaoz7oh	133	37	the	the	DT
cord-304876-txaoz7oh	133	38	PB1	PB1	NNP
cord-304876-txaoz7oh	133	39	domain	domain	NN
cord-304876-txaoz7oh	133	40	.	.	.
cord-304876-txaoz7oh	134	1	[	[	-LRB-
cord-304876-txaoz7oh	134	2	46	46	CD
cord-304876-txaoz7oh	134	3	]	]	-RRB-
cord-304876-txaoz7oh	134	4	[	[	-LRB-
cord-304876-txaoz7oh	134	5	47	47	CD
cord-304876-txaoz7oh	134	6	]	]	-RRB-
cord-304876-txaoz7oh	135	1	[	[	-LRB-
cord-304876-txaoz7oh	135	2	48	48	CD
cord-304876-txaoz7oh	135	3	]	]	-RRB-
cord-304876-txaoz7oh	136	1	[	[	-LRB-
cord-304876-txaoz7oh	136	2	49	49	CD
cord-304876-txaoz7oh	136	3	]	]	-RRB-
cord-304876-txaoz7oh	136	4	[	[	-LRB-
cord-304876-txaoz7oh	136	5	50	50	CD
cord-304876-txaoz7oh	136	6	]	]	-RRB-
cord-304876-txaoz7oh	137	1	[	[	-LRB-
cord-304876-txaoz7oh	137	2	51	51	CD
cord-304876-txaoz7oh	137	3	]	]	-RRB-
cord-304876-txaoz7oh	138	1	The	the	DT
cord-304876-txaoz7oh	138	2	PB2	PB2	NNP
cord-304876-txaoz7oh	138	3	subunit	subunit	NN
cord-304876-txaoz7oh	138	4	has	have	VBZ
cord-304876-txaoz7oh	138	5	an	an	DT
cord-304876-txaoz7oh	138	6	N	n	CD
cord-304876-txaoz7oh	138	7	-	-	HYPH
cord-304876-txaoz7oh	138	8	terminal	terminal	NN
cord-304876-txaoz7oh	138	9	domain	domain	NN
cord-304876-txaoz7oh	138	10	(	(	-LRB-
cord-304876-txaoz7oh	138	11	PB2-N	PB2-N	NNP
cord-304876-txaoz7oh	138	12	)	)	-RRB-
cord-304876-txaoz7oh	138	13	from	from	IN
cord-304876-txaoz7oh	138	14	residues	residue	NNS
cord-304876-txaoz7oh	138	15	1	1	CD
cord-304876-txaoz7oh	138	16	to	to	IN
cord-304876-txaoz7oh	138	17	247	247	CD
cord-304876-txaoz7oh	138	18	and	and	CC
cord-304876-txaoz7oh	138	19	a	a	DT
cord-304876-txaoz7oh	138	20	C	c	NN
cord-304876-txaoz7oh	138	21	-	-	HYPH
cord-304876-txaoz7oh	138	22	terminal	terminal	NN
cord-304876-txaoz7oh	138	23	domain	domain	NN
cord-304876-txaoz7oh	138	24	(	(	-LRB-
cord-304876-txaoz7oh	138	25	PB2-C	PB2-C	NNP
cord-304876-txaoz7oh	138	26	)	)	-RRB-
cord-304876-txaoz7oh	138	27	from	from	IN
cord-304876-txaoz7oh	138	28	residues	residue	NNS
cord-304876-txaoz7oh	138	29	248	248	CD
cord-304876-txaoz7oh	138	30	to	to	IN
cord-304876-txaoz7oh	138	31	760	760	CD
cord-304876-txaoz7oh	138	32	.	.	.
cord-304876-txaoz7oh	139	1	52	52	CD
cord-304876-txaoz7oh	139	2	PB2-N	PB2-N	NNP
cord-304876-txaoz7oh	139	3	,	,	,
cord-304876-txaoz7oh	139	4	including	include	VBG
cord-304876-txaoz7oh	139	5	a	a	DT
cord-304876-txaoz7oh	139	6	lid	lid	NN
cord-304876-txaoz7oh	139	7	domain	domain	NN
cord-304876-txaoz7oh	139	8	,	,	,
cord-304876-txaoz7oh	139	9	interacts	interact	VBZ
cord-304876-txaoz7oh	139	10	with	with	IN
cord-304876-txaoz7oh	139	11	the	the	DT
cord-304876-txaoz7oh	139	12	C	C	NNP
cord-304876-txaoz7oh	139	13	-	-	HYPH
cord-304876-txaoz7oh	139	14	terminal	terminal	NN
cord-304876-txaoz7oh	139	15	extension	extension	NN
cord-304876-txaoz7oh	139	16	and	and	CC
cord-304876-txaoz7oh	139	17	thumb	thumb	NN
cord-304876-txaoz7oh	139	18	of	of	IN
cord-304876-txaoz7oh	139	19	PB1	PB1	NNP
cord-304876-txaoz7oh	139	20	.	.	.
cord-304876-txaoz7oh	140	1	52	52	CD
cord-304876-txaoz7oh	141	1	The	the	DT
cord-304876-txaoz7oh	141	2	PB2-C	PB2-C	NNP
cord-304876-txaoz7oh	141	3	includes	include	VBZ
cord-304876-txaoz7oh	141	4	several	several	JJ
cord-304876-txaoz7oh	141	5	notable	notable	JJ
cord-304876-txaoz7oh	141	6	structural	structural	JJ
cord-304876-txaoz7oh	141	7	features	feature	NNS
cord-304876-txaoz7oh	141	8	and	and	CC
cord-304876-txaoz7oh	141	9	subdomains	subdomain	NNS
cord-304876-txaoz7oh	141	10	such	such	JJ
cord-304876-txaoz7oh	141	11	as	as	IN
cord-304876-txaoz7oh	141	12	the	the	DT
cord-304876-txaoz7oh	141	13	C	C	NNP
cord-304876-txaoz7oh	141	14	-	-	HYPH
cord-304876-txaoz7oh	141	15	terminal	terminal	NN
cord-304876-txaoz7oh	141	16	nuclear	nuclear	JJ
cord-304876-txaoz7oh	141	17	localization	localization	NN
cord-304876-txaoz7oh	141	18	signal	signal	NN
cord-304876-txaoz7oh	141	19	,	,	,
cord-304876-txaoz7oh	141	20	the	the	DT
cord-304876-txaoz7oh	141	21	PB2	PB2	NNP
cord-304876-txaoz7oh	141	22	627-domain	627-domain	CD
cord-304876-txaoz7oh	141	23	,	,	,
cord-304876-txaoz7oh	141	24	the	the	DT
cord-304876-txaoz7oh	141	25	PB2	PB2	NNP
cord-304876-txaoz7oh	141	26	cap-627	cap-627	NNP
cord-304876-txaoz7oh	141	27	linker	linker	NN
cord-304876-txaoz7oh	141	28	,	,	,
cord-304876-txaoz7oh	141	29	the	the	DT
cord-304876-txaoz7oh	141	30	mid	mid	JJ
cord-304876-txaoz7oh	141	31	domain	domain	NN
cord-304876-txaoz7oh	141	32	,	,	,
cord-304876-txaoz7oh	141	33	and	and	CC
cord-304876-txaoz7oh	141	34	a	a	DT
cord-304876-txaoz7oh	141	35	cap	cap	NN
cord-304876-txaoz7oh	141	36	binding	bind	VBG
cord-304876-txaoz7oh	141	37	domain	domain	NN
cord-304876-txaoz7oh	141	38	.	.	.
cord-304876-txaoz7oh	142	1	46	46	CD
cord-304876-txaoz7oh	143	1	Based	base	VBN
cord-304876-txaoz7oh	143	2	on	on	IN
cord-304876-txaoz7oh	143	3	structural	structural	JJ
cord-304876-txaoz7oh	143	4	biology	biology	NN
cord-304876-txaoz7oh	143	5	,	,	,
cord-304876-txaoz7oh	143	6	the	the	DT
cord-304876-txaoz7oh	143	7	PB2	PB2	NNP
cord-304876-txaoz7oh	143	8	domain	domain	NN
cord-304876-txaoz7oh	143	9	has	have	VBZ
cord-304876-txaoz7oh	143	10	a	a	DT
cord-304876-txaoz7oh	143	11	key	key	JJ
cord-304876-txaoz7oh	143	12	exterior	exterior	NN
cord-304876-txaoz7oh	143	13	,	,	,
cord-304876-txaoz7oh	143	14	positively	positively	RB
cord-304876-txaoz7oh	143	15	charged	charge	VBN
cord-304876-txaoz7oh	143	16	residue	residue	NN
cord-304876-txaoz7oh	143	17	at	at	IN
cord-304876-txaoz7oh	143	18	the	the	DT
cord-304876-txaoz7oh	143	19	627	627	CD
cord-304876-txaoz7oh	143	20	position	position	NN
cord-304876-txaoz7oh	143	21	within	within	IN
cord-304876-txaoz7oh	143	22	a	a	DT
cord-304876-txaoz7oh	143	23	flexible	flexible	JJ
cord-304876-txaoz7oh	143	24	loop	loop	NN
cord-304876-txaoz7oh	143	25	that	that	WDT
cord-304876-txaoz7oh	143	26	partially	partially	RB
cord-304876-txaoz7oh	143	27	wraps	wrap	VBZ
cord-304876-txaoz7oh	143	28	around	around	IN
cord-304876-txaoz7oh	143	29	an	an	DT
cord-304876-txaoz7oh	143	30	alpha	alpha	NN
cord-304876-txaoz7oh	143	31	helix	helix	NN
cord-304876-txaoz7oh	143	32	to	to	TO
cord-304876-txaoz7oh	143	33	form	form	VB
cord-304876-txaoz7oh	143	34	what	what	WP
cord-304876-txaoz7oh	143	35	is	be	VBZ
cord-304876-txaoz7oh	143	36	known	know	VBN
cord-304876-txaoz7oh	143	37	as	as	IN
cord-304876-txaoz7oh	143	38	a	a	DT
cord-304876-txaoz7oh	143	39	phi	phi	NN
cord-304876-txaoz7oh	143	40	-	-	HYPH
cord-304876-txaoz7oh	143	41	loop	loop	NN
cord-304876-txaoz7oh	143	42	.	.	.
cord-304876-txaoz7oh	144	1	53	53	CD
cord-304876-txaoz7oh	145	1	Importantly	importantly	RB
cord-304876-txaoz7oh	145	2	,	,	,
cord-304876-txaoz7oh	145	3	this	this	DT
cord-304876-txaoz7oh	145	4	residue	residue	NN
cord-304876-txaoz7oh	145	5	is	be	VBZ
cord-304876-txaoz7oh	145	6	in	in	IN
cord-304876-txaoz7oh	145	7	the	the	DT
cord-304876-txaoz7oh	145	8	middle	middle	NN
cord-304876-txaoz7oh	145	9	of	of	IN
cord-304876-txaoz7oh	145	10	a	a	DT
cord-304876-txaoz7oh	145	11	set	set	NN
cord-304876-txaoz7oh	145	12	of	of	IN
cord-304876-txaoz7oh	145	13	highly	highly	RB
cord-304876-txaoz7oh	145	14	conserved	conserve	VBN
cord-304876-txaoz7oh	145	15	,	,	,
cord-304876-txaoz7oh	145	16	basic	basic	JJ
cord-304876-txaoz7oh	145	17	residues	residue	NNS
cord-304876-txaoz7oh	145	18	forming	form	VBG
cord-304876-txaoz7oh	145	19	a	a	DT
cord-304876-txaoz7oh	145	20	net	net	JJ
cord-304876-txaoz7oh	145	21	positive	positive	JJ
cord-304876-txaoz7oh	145	22	charge	charge	NN
cord-304876-txaoz7oh	145	23	.	.	.
cord-304876-txaoz7oh	146	1	A	a	DT
cord-304876-txaoz7oh	146	2	signature	signature	NN
cord-304876-txaoz7oh	146	3	structural	structural	JJ
cord-304876-txaoz7oh	146	4	element	element	NN
cord-304876-txaoz7oh	146	5	is	be	VBZ
cord-304876-txaoz7oh	146	6	the	the	DT
cord-304876-txaoz7oh	146	7	conserved	conserved	JJ
cord-304876-txaoz7oh	146	8	P[F	P[F	NNP
cord-304876-txaoz7oh	146	9	/	/	SYM
cord-304876-txaoz7oh	146	10	P]AAAPP	p]aaapp	JJ
cord-304876-txaoz7oh	146	11	motif	motif	NN
cord-304876-txaoz7oh	146	12	on	on	IN
cord-304876-txaoz7oh	146	13	the	the	DT
cord-304876-txaoz7oh	146	14	N	n	CD
cord-304876-txaoz7oh	146	15	-	-	HYPH
cord-304876-txaoz7oh	146	16	terminal	terminal	JJ
cord-304876-txaoz7oh	146	17	side	side	NN
cord-304876-txaoz7oh	146	18	of	of	IN
cord-304876-txaoz7oh	146	19	the	the	DT
cord-304876-txaoz7oh	146	20	627	627	CD
cord-304876-txaoz7oh	146	21	residue	residue	NN
cord-304876-txaoz7oh	146	22	that	that	WDT
cord-304876-txaoz7oh	146	23	is	be	VBZ
cord-304876-txaoz7oh	146	24	part	part	NN
cord-304876-txaoz7oh	146	25	of	of	IN
cord-304876-txaoz7oh	146	26	the	the	DT
cord-304876-txaoz7oh	146	27	alpha	alpha	NN
cord-304876-txaoz7oh	146	28	helix	helix	NN
cord-304876-txaoz7oh	146	29	previously	previously	RB
cord-304876-txaoz7oh	146	30	described	describe	VBN
cord-304876-txaoz7oh	146	31	.	.	.
cord-304876-txaoz7oh	147	1	53	53	CD
cord-304876-txaoz7oh	147	2	Mutation	mutation	NN
cord-304876-txaoz7oh	147	3	of	of	IN
cord-304876-txaoz7oh	147	4	the	the	DT
cord-304876-txaoz7oh	147	5	P620	P620	NNPS
cord-304876-txaoz7oh	147	6	or	or	CC
cord-304876-txaoz7oh	147	7	F621	F621	NNP
cord-304876-txaoz7oh	147	8	residue	residue	NN
cord-304876-txaoz7oh	147	9	significantly	significantly	RB
cord-304876-txaoz7oh	147	10	decreased	decrease	VBD
cord-304876-txaoz7oh	147	11	the	the	DT
cord-304876-txaoz7oh	147	12	ability	ability	NN
cord-304876-txaoz7oh	147	13	of	of	IN
cord-304876-txaoz7oh	147	14	the	the	DT
cord-304876-txaoz7oh	147	15	virus	virus	NN
cord-304876-txaoz7oh	147	16	to	to	TO
cord-304876-txaoz7oh	147	17	replicate	replicate	VB
cord-304876-txaoz7oh	147	18	,	,	,
cord-304876-txaoz7oh	147	19	presumably	presumably	RB
cord-304876-txaoz7oh	147	20	by	by	IN
cord-304876-txaoz7oh	147	21	causing	cause	VBG
cord-304876-txaoz7oh	147	22	a	a	DT
cord-304876-txaoz7oh	147	23	slight	slight	JJ
cord-304876-txaoz7oh	147	24	kink	kink	NN
cord-304876-txaoz7oh	147	25	in	in	IN
cord-304876-txaoz7oh	147	26	the	the	DT
cord-304876-txaoz7oh	147	27	alpha	alpha	NN
cord-304876-txaoz7oh	147	28	helix	helix	NN
cord-304876-txaoz7oh	147	29	that	that	WDT
cord-304876-txaoz7oh	147	30	alters	alter	VBZ
cord-304876-txaoz7oh	147	31	the	the	DT
cord-304876-txaoz7oh	147	32	polymerase	polymerase	NN
cord-304876-txaoz7oh	147	33	function	function	NN
cord-304876-txaoz7oh	147	34	.	.	.
cord-304876-txaoz7oh	148	1	The	the	DT
cord-304876-txaoz7oh	148	2	exact	exact	JJ
cord-304876-txaoz7oh	148	3	role	role	NN
cord-304876-txaoz7oh	148	4	of	of	IN
cord-304876-txaoz7oh	148	5	the	the	DT
cord-304876-txaoz7oh	148	6	PB2	PB2	NNP
cord-304876-txaoz7oh	148	7	627	627	CD
cord-304876-txaoz7oh	148	8	domain	domain	NN
cord-304876-txaoz7oh	148	9	remains	remain	VBZ
cord-304876-txaoz7oh	148	10	unclear	unclear	JJ
cord-304876-txaoz7oh	148	11	,	,	,
cord-304876-txaoz7oh	148	12	but	but	CC
cord-304876-txaoz7oh	148	13	recent	recent	JJ
cord-304876-txaoz7oh	148	14	evidence	evidence	NN
cord-304876-txaoz7oh	148	15	suggests	suggest	VBZ
cord-304876-txaoz7oh	148	16	it	-PRON-	PRP
cord-304876-txaoz7oh	148	17	is	be	VBZ
cord-304876-txaoz7oh	148	18	not	not	RB
cord-304876-txaoz7oh	148	19	necessary	necessary	JJ
cord-304876-txaoz7oh	148	20	for	for	IN
cord-304876-txaoz7oh	148	21	in	in	FW
cord-304876-txaoz7oh	148	22	vitro	vitro	FW
cord-304876-txaoz7oh	148	23	binding	binding	NN
cord-304876-txaoz7oh	148	24	and	and	CC
cord-304876-txaoz7oh	148	25	transcription	transcription	NN
cord-304876-txaoz7oh	148	26	of	of	IN
cord-304876-txaoz7oh	148	27	viral	viral	JJ
cord-304876-txaoz7oh	148	28	RNA	RNA	NNP
cord-304876-txaoz7oh	148	29	;	;	:
cord-304876-txaoz7oh	148	30	this	this	DT
cord-304876-txaoz7oh	148	31	has	have	VBZ
cord-304876-txaoz7oh	148	32	not	not	RB
cord-304876-txaoz7oh	148	33	been	be	VBN
cord-304876-txaoz7oh	148	34	proven	prove	VBN
cord-304876-txaoz7oh	148	35	true	true	JJ
cord-304876-txaoz7oh	148	36	in	in	IN
cord-304876-txaoz7oh	148	37	a	a	DT
cord-304876-txaoz7oh	148	38	cell	cell	NN
cord-304876-txaoz7oh	148	39	-	-	HYPH
cord-304876-txaoz7oh	148	40	based	base	VBN
cord-304876-txaoz7oh	148	41	format	format	NN
cord-304876-txaoz7oh	148	42	.	.	.
cord-304876-txaoz7oh	149	1	54	54	CD
cord-304876-txaoz7oh	150	1	The	the	DT
cord-304876-txaoz7oh	150	2	PB1	pb1	JJ
cord-304876-txaoz7oh	150	3	domain	domain	NN
cord-304876-txaoz7oh	150	4	is	be	VBZ
cord-304876-txaoz7oh	150	5	at	at	IN
cord-304876-txaoz7oh	150	6	the	the	DT
cord-304876-txaoz7oh	150	7	center	center	NN
cord-304876-txaoz7oh	150	8	of	of	IN
cord-304876-txaoz7oh	150	9	the	the	DT
cord-304876-txaoz7oh	150	10	polymerase	polymerase	NN
cord-304876-txaoz7oh	150	11	complex	complex	NN
cord-304876-txaoz7oh	150	12	and	and	CC
cord-304876-txaoz7oh	150	13	within	within	IN
cord-304876-txaoz7oh	150	14	its	-PRON-	PRP$
cord-304876-txaoz7oh	150	15	center	center	NN
cord-304876-txaoz7oh	150	16	is	be	VBZ
cord-304876-txaoz7oh	150	17	a	a	DT
cord-304876-txaoz7oh	150	18	classic	classic	JJ
cord-304876-txaoz7oh	150	19	right	right	RB
cord-304876-txaoz7oh	150	20	-	-	HYPH
cord-304876-txaoz7oh	150	21	handed	handed	JJ
cord-304876-txaoz7oh	150	22	shape	shape	NN
cord-304876-txaoz7oh	150	23	with	with	IN
cord-304876-txaoz7oh	150	24	the	the	DT
cord-304876-txaoz7oh	150	25	signature	signature	NN
cord-304876-txaoz7oh	150	26	fingers	finger	NNS
cord-304876-txaoz7oh	150	27	,	,	,
cord-304876-txaoz7oh	150	28	palm	palm	NN
cord-304876-txaoz7oh	150	29	,	,	,
cord-304876-txaoz7oh	150	30	and	and	CC
cord-304876-txaoz7oh	150	31	thumb	thumb	NN
cord-304876-txaoz7oh	150	32	subdomains	subdomain	NNS
cord-304876-txaoz7oh	150	33	(	(	-LRB-
cord-304876-txaoz7oh	150	34	see	see	VB
cord-304876-txaoz7oh	150	35	Figure	figure	NN
cord-304876-txaoz7oh	150	36	2	2	CD
cord-304876-txaoz7oh	150	37	)	)	-RRB-
cord-304876-txaoz7oh	150	38	.	.	.
cord-304876-txaoz7oh	151	1	5	5	LS
cord-304876-txaoz7oh	152	1	These	these	DT
cord-304876-txaoz7oh	152	2	subdomains	subdomain	NNS
cord-304876-txaoz7oh	152	3	are	be	VBP
cord-304876-txaoz7oh	152	4	described	describe	VBN
cord-304876-txaoz7oh	152	5	as	as	IN
cord-304876-txaoz7oh	152	6	conserved	conserve	VBN
cord-304876-txaoz7oh	152	7	RNA	RNA	NNP
cord-304876-txaoz7oh	152	8	-	-	HYPH
cord-304876-txaoz7oh	152	9	dependent	dependent	JJ
cord-304876-txaoz7oh	152	10	RNA	RNA	NNP
cord-304876-txaoz7oh	152	11	polymerase	polymerase	NN
cord-304876-txaoz7oh	152	12	(	(	-LRB-
cord-304876-txaoz7oh	152	13	RdRp	RdRp	NNP
cord-304876-txaoz7oh	152	14	)	)	-RRB-
cord-304876-txaoz7oh	152	15	motifs	motif	NNS
cord-304876-txaoz7oh	152	16	pre	pre	VBP
cord-304876-txaoz7oh	152	17	-	-	JJ
cord-304876-txaoz7oh	152	18	A	a	NN
cord-304876-txaoz7oh	152	19	/	/	SYM
cord-304876-txaoz7oh	152	20	F	f	NN
cord-304876-txaoz7oh	152	21	and	and	CC
cord-304876-txaoz7oh	152	22	A	A	NNP
cord-304876-txaoz7oh	152	23	-	-	HYPH
cord-304876-txaoz7oh	152	24	E.	E.	NNP
cord-304876-txaoz7oh	152	25	52	52	CD
cord-304876-txaoz7oh	153	1	The	the	DT
cord-304876-txaoz7oh	153	2	pre	pre	JJ
cord-304876-txaoz7oh	153	3	-	-	JJ
cord-304876-txaoz7oh	153	4	A	a	NN
cord-304876-txaoz7oh	153	5	/	/	SYM
cord-304876-txaoz7oh	153	6	F	f	NN
cord-304876-txaoz7oh	153	7	motif	motif	NN
cord-304876-txaoz7oh	153	8	describes	describe	VBZ
cord-304876-txaoz7oh	153	9	the	the	DT
cord-304876-txaoz7oh	153	10	fingertips	fingertip	NNS
cord-304876-txaoz7oh	153	11	and	and	CC
cord-304876-txaoz7oh	153	12	a	a	DT
cord-304876-txaoz7oh	153	13	small	small	JJ
cord-304876-txaoz7oh	153	14	loop	loop	NN
cord-304876-txaoz7oh	153	15	,	,	,
cord-304876-txaoz7oh	153	16	which	which	WDT
cord-304876-txaoz7oh	153	17	spreads	spread	VBZ
cord-304876-txaoz7oh	153	18	over	over	RP
cord-304876-txaoz7oh	153	19	to	to	IN
cord-304876-txaoz7oh	153	20	the	the	DT
cord-304876-txaoz7oh	153	21	thumb	thumb	NN
cord-304876-txaoz7oh	153	22	domain	domain	NN
cord-304876-txaoz7oh	153	23	;	;	:
cord-304876-txaoz7oh	153	24	the	the	DT
cord-304876-txaoz7oh	153	25	tip	tip	NN
cord-304876-txaoz7oh	153	26	of	of	IN
cord-304876-txaoz7oh	153	27	this	this	DT
cord-304876-txaoz7oh	153	28	loop	loop	NN
cord-304876-txaoz7oh	153	29	is	be	VBZ
cord-304876-txaoz7oh	153	30	stabilized	stabilize	VBN
cord-304876-txaoz7oh	153	31	by	by	IN
cord-304876-txaoz7oh	153	32	an	an	DT
cord-304876-txaoz7oh	153	33	alpha	alpha	NN
cord-304876-txaoz7oh	153	34	helix	helix	NN
cord-304876-txaoz7oh	153	35	within	within	IN
cord-304876-txaoz7oh	153	36	the	the	DT
cord-304876-txaoz7oh	153	37	PA	PA	NNP
cord-304876-txaoz7oh	153	38	domain	domain	NN
cord-304876-txaoz7oh	153	39	.	.	.
cord-304876-txaoz7oh	154	1	Residues	residue	NNS
cord-304876-txaoz7oh	154	2	within	within	IN
cord-304876-txaoz7oh	154	3	the	the	DT
cord-304876-txaoz7oh	154	4	pre	pre	JJ
cord-304876-txaoz7oh	154	5	-	-	JJ
cord-304876-txaoz7oh	154	6	A	A	NNP
cord-304876-txaoz7oh	154	7	/	/	SYM
cord-304876-txaoz7oh	154	8	F	F	NNP
cord-304876-txaoz7oh	154	9	may	may	MD
cord-304876-txaoz7oh	154	10	guide	guide	VB
cord-304876-txaoz7oh	154	11	and	and	CC
cord-304876-txaoz7oh	154	12	bind	bind	VB
cord-304876-txaoz7oh	154	13	NTPs	ntp	NNS
cord-304876-txaoz7oh	154	14	and	and	CC
cord-304876-txaoz7oh	154	15	the	the	DT
cord-304876-txaoz7oh	154	16	incoming	incoming	JJ
cord-304876-txaoz7oh	154	17	template	template	NN
cord-304876-txaoz7oh	154	18	.	.	.
cord-304876-txaoz7oh	155	1	In	in	IN
cord-304876-txaoz7oh	155	2	addition	addition	NN
cord-304876-txaoz7oh	155	3	to	to	IN
cord-304876-txaoz7oh	155	4	these	these	DT
cord-304876-txaoz7oh	155	5	subdomains	subdomain	NNS
cord-304876-txaoz7oh	155	6	,	,	,
cord-304876-txaoz7oh	155	7	N	n	CD
cord-304876-txaoz7oh	155	8	-	-	HYPH
cord-304876-txaoz7oh	155	9	terminal	terminal	NN
cord-304876-txaoz7oh	155	10	and	and	CC
cord-304876-txaoz7oh	155	11	C	c	NN
cord-304876-txaoz7oh	155	12	-	-	HYPH
cord-304876-txaoz7oh	155	13	terminal	terminal	NN
cord-304876-txaoz7oh	155	14	extensions	extension	NNS
cord-304876-txaoz7oh	155	15	interact	interact	VBP
cord-304876-txaoz7oh	155	16	with	with	IN
cord-304876-txaoz7oh	155	17	PA	PA	NNP
cord-304876-txaoz7oh	155	18	and	and	CC
cord-304876-txaoz7oh	155	19	PB2	PB2	NNP
cord-304876-txaoz7oh	155	20	domains	domain	NNS
cord-304876-txaoz7oh	155	21	.	.	.
cord-304876-txaoz7oh	156	1	The	the	DT
cord-304876-txaoz7oh	156	2	fingers	finger	NNS
cord-304876-txaoz7oh	156	3	and	and	CC
cord-304876-txaoz7oh	156	4	palm	palm	NN
cord-304876-txaoz7oh	156	5	are	be	VBP
cord-304876-txaoz7oh	156	6	covered	cover	VBN
cord-304876-txaoz7oh	156	7	by	by	IN
cord-304876-txaoz7oh	156	8	a	a	DT
cord-304876-txaoz7oh	156	9	linker	linker	NN
cord-304876-txaoz7oh	156	10	connecting	connect	VBG
cord-304876-txaoz7oh	156	11	the	the	DT
cord-304876-txaoz7oh	156	12	two	two	CD
cord-304876-txaoz7oh	156	13	subdomains	subdomain	NNS
cord-304876-txaoz7oh	156	14	of	of	IN
cord-304876-txaoz7oh	156	15	PA	PA	NNP
cord-304876-txaoz7oh	156	16	.	.	.
cord-304876-txaoz7oh	157	1	The	the	DT
cord-304876-txaoz7oh	157	2	PB1	pb1	NN
cord-304876-txaoz7oh	157	3	possesses	possess	VBZ
cord-304876-txaoz7oh	157	4	a	a	DT
cord-304876-txaoz7oh	157	5	b	b	NN
cord-304876-txaoz7oh	157	6	-	-	HYPH
cord-304876-txaoz7oh	157	7	hairpin	hairpin	NN
cord-304876-txaoz7oh	157	8	loop	loop	NN
cord-304876-txaoz7oh	157	9	within	within	IN
cord-304876-txaoz7oh	157	10	motif	motif	NN
cord-304876-txaoz7oh	157	11	E	e	NN
cord-304876-txaoz7oh	157	12	from	from	IN
cord-304876-txaoz7oh	157	13	residues	residue	NNS
cord-304876-txaoz7oh	157	14	641	641	CD
cord-304876-txaoz7oh	157	15	to	to	IN
cord-304876-txaoz7oh	157	16	657	657	CD
cord-304876-txaoz7oh	157	17	in	in	IN
cord-304876-txaoz7oh	157	18	the	the	DT
cord-304876-txaoz7oh	157	19	thumb	thumb	NN
cord-304876-txaoz7oh	157	20	subdomain	subdomain	NN
cord-304876-txaoz7oh	157	21	of	of	IN
cord-304876-txaoz7oh	157	22	influenza	influenza	NN
cord-304876-txaoz7oh	157	23	A.	a.	NN
cord-304876-txaoz7oh	157	24	46	46	CD
cord-304876-txaoz7oh	158	1	In	in	IN
cord-304876-txaoz7oh	158	2	de	de	FW
cord-304876-txaoz7oh	158	3	novo	novo	NNP
cord-304876-txaoz7oh	158	4	initiation	initiation	NN
cord-304876-txaoz7oh	158	5	,	,	,
cord-304876-txaoz7oh	158	6	it	-PRON-	PRP
cord-304876-txaoz7oh	158	7	has	have	VBZ
cord-304876-txaoz7oh	158	8	been	be	VBN
cord-304876-txaoz7oh	158	9	shown	show	VBN
cord-304876-txaoz7oh	158	10	with	with	IN
cord-304876-txaoz7oh	158	11	other	other	JJ
cord-304876-txaoz7oh	158	12	related	related	JJ
cord-304876-txaoz7oh	158	13	polymerases	polymerase	NNS
cord-304876-txaoz7oh	158	14	that	that	IN
cord-304876-txaoz7oh	158	15	this	this	DT
cord-304876-txaoz7oh	158	16	priming	priming	NN
cord-304876-txaoz7oh	158	17	loop	loop	NN
cord-304876-txaoz7oh	158	18	may	may	MD
cord-304876-txaoz7oh	158	19	serve	serve	VB
cord-304876-txaoz7oh	158	20	as	as	IN
cord-304876-txaoz7oh	158	21	a	a	DT
cord-304876-txaoz7oh	158	22	platform	platform	NN
cord-304876-txaoz7oh	158	23	for	for	IN
cord-304876-txaoz7oh	158	24	the	the	DT
cord-304876-txaoz7oh	158	25	initial	initial	JJ
cord-304876-txaoz7oh	158	26	NTP	ntp	NN
cord-304876-txaoz7oh	158	27	on	on	IN
cord-304876-txaoz7oh	158	28	the	the	DT
cord-304876-txaoz7oh	158	29	3	3	CD
cord-304876-txaoz7oh	158	30	0	0	CD
cord-304876-txaoz7oh	158	31	end	end	NN
cord-304876-txaoz7oh	158	32	of	of	IN
cord-304876-txaoz7oh	158	33	the	the	DT
cord-304876-txaoz7oh	158	34	template	template	NN
cord-304876-txaoz7oh	158	35	and	and	CC
cord-304876-txaoz7oh	158	36	ensure	ensure	VB
cord-304876-txaoz7oh	158	37	against	against	IN
cord-304876-txaoz7oh	158	38	double	double	RB
cord-304876-txaoz7oh	158	39	-	-	HYPH
cord-304876-txaoz7oh	158	40	stranded	strand	VBN
cord-304876-txaoz7oh	158	41	RNA	RNA	NNP
cord-304876-txaoz7oh	158	42	.	.	.
cord-304876-txaoz7oh	159	1	Biochemical	biochemical	JJ
cord-304876-txaoz7oh	159	2	investigations	investigation	NNS
cord-304876-txaoz7oh	159	3	have	have	VBP
cord-304876-txaoz7oh	159	4	shown	show	VBN
cord-304876-txaoz7oh	159	5	that	that	IN
cord-304876-txaoz7oh	159	6	the	the	DT
cord-304876-txaoz7oh	159	7	proline	proline	NN
cord-304876-txaoz7oh	159	8	found	find	VBN
cord-304876-txaoz7oh	159	9	within	within	IN
cord-304876-txaoz7oh	159	10	the	the	DT
cord-304876-txaoz7oh	159	11	loop	loop	NN
cord-304876-txaoz7oh	159	12	tip	tip	NN
cord-304876-txaoz7oh	159	13	motif	motif	NN
cord-304876-txaoz7oh	159	14	of	of	IN
cord-304876-txaoz7oh	159	15	648-Ala	648-ala	CD
cord-304876-txaoz7oh	159	16	-	-	HYPH
cord-304876-txaoz7oh	159	17	His	His	NNP
cord-304876-txaoz7oh	159	18	-	-	HYPH
cord-304876-txaoz7oh	159	19	Gly	Gly	NNP
cord-304876-txaoz7oh	159	20	-	-	HYPH
cord-304876-txaoz7oh	159	21	Pro	Pro	NNP
cord-304876-txaoz7oh	159	22	is	be	VBZ
cord-304876-txaoz7oh	159	23	necessary	necessary	JJ
cord-304876-txaoz7oh	159	24	for	for	IN
cord-304876-txaoz7oh	159	25	in	in	FW
cord-304876-txaoz7oh	159	26	vitro	vitro	FW
cord-304876-txaoz7oh	159	27	and	and	CC
cord-304876-txaoz7oh	159	28	cell	cell	NN
cord-304876-txaoz7oh	159	29	-	-	HYPH
cord-304876-txaoz7oh	159	30	based	base	VBN
cord-304876-txaoz7oh	159	31	RNA	RNA	NNP
cord-304876-txaoz7oh	159	32	synthesis	synthesis	NN
cord-304876-txaoz7oh	159	33	.	.	.
cord-304876-txaoz7oh	160	1	This	this	DT
cord-304876-txaoz7oh	160	2	loop	loop	NN
cord-304876-txaoz7oh	160	3	may	may	MD
cord-304876-txaoz7oh	160	4	also	also	RB
cord-304876-txaoz7oh	160	5	be	be	VB
cord-304876-txaoz7oh	160	6	necessary	necessary	JJ
cord-304876-txaoz7oh	160	7	during	during	IN
cord-304876-txaoz7oh	160	8	replication	replication	NN
cord-304876-txaoz7oh	160	9	mode	mode	NN
cord-304876-txaoz7oh	160	10	for	for	IN
cord-304876-txaoz7oh	160	11	terminal	terminal	NN
cord-304876-txaoz7oh	160	12	de	de	FW
cord-304876-txaoz7oh	160	13	novo	novo	NNP
cord-304876-txaoz7oh	160	14	initiation	initiation	NN
cord-304876-txaoz7oh	160	15	but	but	CC
cord-304876-txaoz7oh	160	16	unnecessary	unnecessary	JJ
cord-304876-txaoz7oh	160	17	for	for	IN
cord-304876-txaoz7oh	160	18	internal	internal	JJ
cord-304876-txaoz7oh	160	19	initiation	initiation	NN
cord-304876-txaoz7oh	160	20	and	and	CC
cord-304876-txaoz7oh	160	21	transcription	transcription	NN
cord-304876-txaoz7oh	160	22	.	.	.
cord-304876-txaoz7oh	161	1	55	55	CD
cord-304876-txaoz7oh	162	1	The	the	DT
cord-304876-txaoz7oh	162	2	PA	PA	NNP
cord-304876-txaoz7oh	162	3	endonuclease	endonuclease	NN
cord-304876-txaoz7oh	162	4	domain	domain	NN
cord-304876-txaoz7oh	162	5	or	or	CC
cord-304876-txaoz7oh	162	6	the	the	DT
cord-304876-txaoz7oh	162	7	PA	PA	NNP
cord-304876-txaoz7oh	162	8	subunit	subunit	NN
cord-304876-txaoz7oh	162	9	,	,	,
cord-304876-txaoz7oh	162	10	as	as	IN
cord-304876-txaoz7oh	162	11	it	-PRON-	PRP
cord-304876-txaoz7oh	162	12	will	will	MD
cord-304876-txaoz7oh	162	13	be	be	VB
cord-304876-txaoz7oh	162	14	named	name	VBN
cord-304876-txaoz7oh	162	15	here	here	RB
cord-304876-txaoz7oh	162	16	,	,	,
cord-304876-txaoz7oh	162	17	has	have	VBZ
cord-304876-txaoz7oh	162	18	little	little	JJ
cord-304876-txaoz7oh	162	19	homology	homology	NN
cord-304876-txaoz7oh	162	20	to	to	IN
cord-304876-txaoz7oh	162	21	other	other	JJ
cord-304876-txaoz7oh	162	22	proteins	protein	NNS
cord-304876-txaoz7oh	162	23	and	and	CC
cord-304876-txaoz7oh	162	24	its	-PRON-	PRP$
cord-304876-txaoz7oh	162	25	exact	exact	JJ
cord-304876-txaoz7oh	162	26	enzymatic	enzymatic	JJ
cord-304876-txaoz7oh	162	27	function	function	NN
cord-304876-txaoz7oh	162	28	was	be	VBD
cord-304876-txaoz7oh	162	29	discovered	discover	VBN
cord-304876-txaoz7oh	162	30	only	only	RB
cord-304876-txaoz7oh	162	31	recently	recently	RB
cord-304876-txaoz7oh	162	32	.	.	.
cord-304876-txaoz7oh	163	1	The	the	DT
cord-304876-txaoz7oh	163	2	subunit	subunit	NN
cord-304876-txaoz7oh	163	3	was	be	VBD
cord-304876-txaoz7oh	163	4	expressed	express	VBN
cord-304876-txaoz7oh	163	5	in	in	IN
cord-304876-txaoz7oh	163	6	insect	insect	NN
cord-304876-txaoz7oh	163	7	cells	cell	NNS
cord-304876-txaoz7oh	163	8	to	to	TO
cord-304876-txaoz7oh	163	9	reveal	reveal	VB
cord-304876-txaoz7oh	163	10	an	an	DT
cord-304876-txaoz7oh	163	11	N	n	CD
cord-304876-txaoz7oh	163	12	-	-	HYPH
cord-304876-txaoz7oh	163	13	terminal	terminal	NN
cord-304876-txaoz7oh	163	14	third	third	JJ
cord-304876-txaoz7oh	163	15	(	(	-LRB-
cord-304876-txaoz7oh	163	16	PA	PA	NNP
cord-304876-txaoz7oh	163	17	-	-	HYPH
cord-304876-txaoz7oh	163	18	Nter	Nter	NNP
cord-304876-txaoz7oh	163	19	)	)	-RRB-
cord-304876-txaoz7oh	163	20	and	and	CC
cord-304876-txaoz7oh	163	21	a	a	DT
cord-304876-txaoz7oh	163	22	C	c	NN
cord-304876-txaoz7oh	163	23	-	-	HYPH
cord-304876-txaoz7oh	163	24	terminal	terminal	NN
cord-304876-txaoz7oh	163	25	two	two	CD
cord-304876-txaoz7oh	163	26	-	-	HYPH
cord-304876-txaoz7oh	163	27	thirds	third	NNS
cord-304876-txaoz7oh	163	28	(	(	-LRB-
cord-304876-txaoz7oh	163	29	PA	PA	NNP
cord-304876-txaoz7oh	163	30	-	-	HYPH
cord-304876-txaoz7oh	163	31	Cter	Cter	NNP
cord-304876-txaoz7oh	163	32	)	)	-RRB-
cord-304876-txaoz7oh	163	33	subdomains	subdomain	NNS
cord-304876-txaoz7oh	163	34	.	.	.
cord-304876-txaoz7oh	164	1	They	-PRON-	PRP
cord-304876-txaoz7oh	164	2	have	have	VBP
cord-304876-txaoz7oh	164	3	molecular	molecular	JJ
cord-304876-txaoz7oh	164	4	weights	weight	NNS
cord-304876-txaoz7oh	164	5	of	of	IN
cord-304876-txaoz7oh	164	6	25	25	CD
cord-304876-txaoz7oh	164	7	and	and	CC
cord-304876-txaoz7oh	164	8	55	55	CD
cord-304876-txaoz7oh	164	9	kDa	kDa	NNS
cord-304876-txaoz7oh	164	10	,	,	,
cord-304876-txaoz7oh	164	11	respectively	respectively	RB
cord-304876-txaoz7oh	164	12	.	.	.
cord-304876-txaoz7oh	165	1	These	these	DT
cord-304876-txaoz7oh	165	2	two	two	CD
cord-304876-txaoz7oh	165	3	subdomains	subdomain	NNS
cord-304876-txaoz7oh	165	4	are	be	VBP
cord-304876-txaoz7oh	165	5	connected	connect	VBN
cord-304876-txaoz7oh	165	6	by	by	IN
cord-304876-txaoz7oh	165	7	a	a	DT
cord-304876-txaoz7oh	165	8	flexible	flexible	JJ
cord-304876-txaoz7oh	165	9	linker	linker	NN
cord-304876-txaoz7oh	165	10	.	.	.
cord-304876-txaoz7oh	166	1	The	the	DT
cord-304876-txaoz7oh	166	2	endonuclease	endonuclease	NN
cord-304876-txaoz7oh	166	3	activity	activity	NN
cord-304876-txaoz7oh	166	4	was	be	VBD
cord-304876-txaoz7oh	166	5	originally	originally	RB
cord-304876-txaoz7oh	166	6	thought	think	VBN
cord-304876-txaoz7oh	166	7	to	to	TO
cord-304876-txaoz7oh	166	8	occur	occur	VB
cord-304876-txaoz7oh	166	9	through	through	IN
cord-304876-txaoz7oh	166	10	the	the	DT
cord-304876-txaoz7oh	166	11	PB1	PB1	NNP
cord-304876-txaoz7oh	166	12	or	or	CC
cord-304876-txaoz7oh	166	13	PB2	PB2	NNP
cord-304876-txaoz7oh	166	14	domains	domain	NNS
cord-304876-txaoz7oh	166	15	but	but	CC
cord-304876-txaoz7oh	166	16	the	the	DT
cord-304876-txaoz7oh	166	17	structure	structure	NN
cord-304876-txaoz7oh	166	18	of	of	IN
cord-304876-txaoz7oh	166	19	the	the	DT
cord-304876-txaoz7oh	166	20	PA	PA	NNP
cord-304876-txaoz7oh	166	21	-	-	HYPH
cord-304876-txaoz7oh	166	22	Nter	Nter	NNP
cord-304876-txaoz7oh	166	23	was	be	VBD
cord-304876-txaoz7oh	166	24	solved	solve	VBN
cord-304876-txaoz7oh	166	25	by	by	IN
cord-304876-txaoz7oh	166	26	two	two	CD
cord-304876-txaoz7oh	166	27	groups	group	NNS
cord-304876-txaoz7oh	166	28	to	to	TO
cord-304876-txaoz7oh	166	29	reveal	reveal	VB
cord-304876-txaoz7oh	166	30	that	that	IN
cord-304876-txaoz7oh	166	31	the	the	DT
cord-304876-txaoz7oh	166	32	catalytic	catalytic	JJ
cord-304876-txaoz7oh	166	33	residues	residue	NNS
cord-304876-txaoz7oh	166	34	for	for	IN
cord-304876-txaoz7oh	166	35	endonuclease	endonuclease	NN
cord-304876-txaoz7oh	166	36	activity	activity	NN
cord-304876-txaoz7oh	166	37	reside	reside	VBP
cord-304876-txaoz7oh	166	38	in	in	IN
cord-304876-txaoz7oh	166	39	the	the	DT
cord-304876-txaoz7oh	166	40	PA	PA	NNP
cord-304876-txaoz7oh	166	41	domain	domain	NN
cord-304876-txaoz7oh	166	42	,	,	,
cord-304876-txaoz7oh	166	43	not	not	RB
cord-304876-txaoz7oh	166	44	in	in	IN
cord-304876-txaoz7oh	166	45	the	the	DT
cord-304876-txaoz7oh	166	46	PB1	PB1	NNP
cord-304876-txaoz7oh	166	47	subunit	subunit	NN
cord-304876-txaoz7oh	166	48	as	as	RB
cord-304876-txaoz7oh	166	49	originally	originally	RB
cord-304876-txaoz7oh	166	50	thought	think	VBN
cord-304876-txaoz7oh	166	51	.	.	.
cord-304876-txaoz7oh	167	1	50	50	CD
cord-304876-txaoz7oh	167	2	,	,	,
cord-304876-txaoz7oh	167	3	51	51	CD
cord-304876-txaoz7oh	168	1	The	the	DT
cord-304876-txaoz7oh	168	2	PA	PA	NNP
cord-304876-txaoz7oh	168	3	endonuclease	endonuclease	NN
cord-304876-txaoz7oh	168	4	domain	domain	NN
cord-304876-txaoz7oh	168	5	contains	contain	VBZ
cord-304876-txaoz7oh	168	6	a	a	DT
cord-304876-txaoz7oh	168	7	signature	signature	NN
cord-304876-txaoz7oh	168	8	(	(	-LRB-
cord-304876-txaoz7oh	168	9	P)DXN(D	p)dxn(d	NN
cord-304876-txaoz7oh	168	10	/	/	SYM
cord-304876-txaoz7oh	168	11	E)XK	E)XK	NNP
cord-304876-txaoz7oh	168	12	motif	motif	NN
cord-304876-txaoz7oh	168	13	that	that	WDT
cord-304876-txaoz7oh	168	14	is	be	VBZ
cord-304876-txaoz7oh	168	15	conserved	conserve	VBN
cord-304876-txaoz7oh	168	16	among	among	IN
cord-304876-txaoz7oh	168	17	influenza	influenza	NN
cord-304876-txaoz7oh	168	18	viruses	virus	NNS
cord-304876-txaoz7oh	168	19	and	and	CC
cord-304876-txaoz7oh	168	20	coordinate	coordinate	VB
cord-304876-txaoz7oh	168	21	divalent	divalent	JJ
cord-304876-txaoz7oh	168	22	cations	cation	NNS
cord-304876-txaoz7oh	168	23	such	such	JJ
cord-304876-txaoz7oh	168	24	as	as	IN
cord-304876-txaoz7oh	168	25	magnesium	magnesium	NN
cord-304876-txaoz7oh	168	26	or	or	CC
cord-304876-txaoz7oh	168	27	manganese	manganese	NN
cord-304876-txaoz7oh	168	28	.	.	.
cord-304876-txaoz7oh	169	1	56	56	CD
cord-304876-txaoz7oh	170	1	Although	although	IN
cord-304876-txaoz7oh	170	2	the	the	DT
cord-304876-txaoz7oh	170	3	exact	exact	JJ
cord-304876-txaoz7oh	170	4	quantity	quantity	NN
cord-304876-txaoz7oh	170	5	and	and	CC
cord-304876-txaoz7oh	170	6	identity	identity	NN
cord-304876-txaoz7oh	170	7	of	of	IN
cord-304876-txaoz7oh	170	8	ions	ion	NNS
cord-304876-txaoz7oh	170	9	present	present	JJ
cord-304876-txaoz7oh	170	10	in	in	IN
cord-304876-txaoz7oh	170	11	the	the	DT
cord-304876-txaoz7oh	170	12	native	native	JJ
cord-304876-txaoz7oh	170	13	influenza	influenza	NN
cord-304876-txaoz7oh	170	14	enzyme	enzyme	NN
cord-304876-txaoz7oh	170	15	are	be	VBP
cord-304876-txaoz7oh	170	16	unclear	unclear	JJ
cord-304876-txaoz7oh	170	17	,	,	,
cord-304876-txaoz7oh	170	18	the	the	DT
cord-304876-txaoz7oh	170	19	endonuclease	endonuclease	NN
cord-304876-txaoz7oh	170	20	activity	activity	NN
cord-304876-txaoz7oh	170	21	is	be	VBZ
cord-304876-txaoz7oh	170	22	strongly	strongly	RB
cord-304876-txaoz7oh	170	23	activated	activate	VBN
cord-304876-txaoz7oh	170	24	by	by	IN
cord-304876-txaoz7oh	170	25	metal	metal	NN
cord-304876-txaoz7oh	170	26	ion	ion	NN
cord-304876-txaoz7oh	170	27	binding	bind	VBG
cord-304876-txaoz7oh	170	28	through	through	IN
cord-304876-txaoz7oh	170	29	hydrolysis	hydrolysis	NN
cord-304876-txaoz7oh	170	30	of	of	IN
cord-304876-txaoz7oh	170	31	ssDNA	ssdna	NN
cord-304876-txaoz7oh	170	32	and	and	CC
cord-304876-txaoz7oh	170	33	ssRNA	ssrna	NN
cord-304876-txaoz7oh	170	34	substrates	substrate	NNS
cord-304876-txaoz7oh	170	35	.	.	.
cord-304876-txaoz7oh	171	1	Human	human	JJ
cord-304876-txaoz7oh	171	2	metapneumovirus	metapneumovirus	NN
cord-304876-txaoz7oh	171	3	and	and	CC
cord-304876-txaoz7oh	171	4	human	human	JJ
cord-304876-txaoz7oh	171	5	RSV	RSV	NNP
cord-304876-txaoz7oh	171	6	are	be	VBP
cord-304876-txaoz7oh	171	7	nonsegmented	nonsegmente	VBN
cord-304876-txaoz7oh	171	8	,	,	,
cord-304876-txaoz7oh	171	9	negative	negative	JJ
cord-304876-txaoz7oh	171	10	strand	strand	NN
cord-304876-txaoz7oh	171	11	RNA	RNA	NNP
cord-304876-txaoz7oh	171	12	viruses	virus	NNS
cord-304876-txaoz7oh	171	13	from	from	IN
cord-304876-txaoz7oh	171	14	the	the	DT
cord-304876-txaoz7oh	171	15	Pneumoviridae	Pneumoviridae	NNP
cord-304876-txaoz7oh	171	16	family	family	NN
cord-304876-txaoz7oh	171	17	of	of	IN
cord-304876-txaoz7oh	171	18	the	the	DT
cord-304876-txaoz7oh	171	19	order	order	NN
cord-304876-txaoz7oh	171	20	Mononegavirales	Mononegavirales	NNP
cord-304876-txaoz7oh	171	21	.	.	.
cord-304876-txaoz7oh	172	1	The	the	DT
cord-304876-txaoz7oh	172	2	polymerases	polymerase	NNS
cord-304876-txaoz7oh	172	3	from	from	IN
cord-304876-txaoz7oh	172	4	this	this	DT
cord-304876-txaoz7oh	172	5	class	class	NN
cord-304876-txaoz7oh	172	6	of	of	IN
cord-304876-txaoz7oh	172	7	viruses	virus	NNS
cord-304876-txaoz7oh	172	8	are	be	VBP
cord-304876-txaoz7oh	172	9	multifaceted	multifacete	VBN
cord-304876-txaoz7oh	172	10	with	with	IN
cord-304876-txaoz7oh	172	11	multiple	multiple	JJ
cord-304876-txaoz7oh	172	12	enzymatic	enzymatic	JJ
cord-304876-txaoz7oh	172	13	functions	function	NNS
cord-304876-txaoz7oh	172	14	contained	contain	VBN
cord-304876-txaoz7oh	172	15	within	within	IN
cord-304876-txaoz7oh	172	16	a	a	DT
cord-304876-txaoz7oh	172	17	single	single	JJ
cord-304876-txaoz7oh	172	18	protein	protein	NN
cord-304876-txaoz7oh	172	19	.	.	.
cord-304876-txaoz7oh	173	1	It	-PRON-	PRP
cord-304876-txaoz7oh	173	2	exists	exist	VBZ
cord-304876-txaoz7oh	173	3	as	as	IN
cord-304876-txaoz7oh	173	4	part	part	NN
cord-304876-txaoz7oh	173	5	of	of	IN
cord-304876-txaoz7oh	173	6	a	a	DT
cord-304876-txaoz7oh	173	7	ribonucleoprotein	ribonucleoprotein	NN
cord-304876-txaoz7oh	173	8	complex	complex	NN
cord-304876-txaoz7oh	173	9	,	,	,
cord-304876-txaoz7oh	173	10	or	or	CC
cord-304876-txaoz7oh	173	11	replicase	replicase	NNP
cord-304876-txaoz7oh	173	12	,	,	,
cord-304876-txaoz7oh	173	13	composed	compose	VBN
cord-304876-txaoz7oh	173	14	of	of	IN
cord-304876-txaoz7oh	173	15	L	L	NNP
cord-304876-txaoz7oh	173	16	,	,	,
cord-304876-txaoz7oh	173	17	N	N	NNP
cord-304876-txaoz7oh	173	18	,	,	,
cord-304876-txaoz7oh	173	19	P	P	NNP
cord-304876-txaoz7oh	173	20	,	,	,
cord-304876-txaoz7oh	173	21	and	and	CC
cord-304876-txaoz7oh	173	22	M2	M2	NNP
cord-304876-txaoz7oh	173	23	-	-	HYPH
cord-304876-txaoz7oh	173	24	1	1	CD
cord-304876-txaoz7oh	173	25	proteins	protein	NNS
cord-304876-txaoz7oh	173	26	in	in	IN
cord-304876-txaoz7oh	173	27	complex	complex	NN
cord-304876-txaoz7oh	173	28	with	with	IN
cord-304876-txaoz7oh	173	29	RNA	RNA	NNP
cord-304876-txaoz7oh	173	30	.	.	.
cord-304876-txaoz7oh	174	1	These	these	DT
cord-304876-txaoz7oh	174	2	include	include	VBP
cord-304876-txaoz7oh	174	3	RNA	RNA	NNP
cord-304876-txaoz7oh	174	4	synthesis	synthesis	NN
cord-304876-txaoz7oh	174	5	activities	activity	NNS
cord-304876-txaoz7oh	174	6	carried	carry	VBN
cord-304876-txaoz7oh	174	7	out	out	RP
cord-304876-txaoz7oh	174	8	by	by	IN
cord-304876-txaoz7oh	174	9	an	an	DT
cord-304876-txaoz7oh	174	10	RdRp	RdRp	NNP
cord-304876-txaoz7oh	174	11	domain	domain	NN
cord-304876-txaoz7oh	174	12	but	but	CC
cord-304876-txaoz7oh	174	13	also	also	RB
cord-304876-txaoz7oh	174	14	include	include	VBP
cord-304876-txaoz7oh	174	15	capping	cap	VBG
cord-304876-txaoz7oh	174	16	and	and	CC
cord-304876-txaoz7oh	174	17	methylation	methylation	NN
cord-304876-txaoz7oh	174	18	functions	function	NNS
cord-304876-txaoz7oh	174	19	.	.	.
cord-304876-txaoz7oh	175	1	The	the	DT
cord-304876-txaoz7oh	175	2	RdRp	RdRp	NNP
cord-304876-txaoz7oh	175	3	carries	carry	VBZ
cord-304876-txaoz7oh	175	4	out	out	RP
cord-304876-txaoz7oh	175	5	transcription	transcription	NN
cord-304876-txaoz7oh	175	6	and	and	CC
cord-304876-txaoz7oh	175	7	replication	replication	NN
cord-304876-txaoz7oh	175	8	of	of	IN
cord-304876-txaoz7oh	175	9	its	-PRON-	PRP$
cord-304876-txaoz7oh	175	10	genome	genome	NN
cord-304876-txaoz7oh	175	11	in	in	IN
cord-304876-txaoz7oh	175	12	response	response	NN
cord-304876-txaoz7oh	175	13	to	to	IN
cord-304876-txaoz7oh	175	14	cis	cis	NNP
cord-304876-txaoz7oh	175	15	-	-	HYPH
cord-304876-txaoz7oh	175	16	acting	act	VBG
cord-304876-txaoz7oh	175	17	elements	element	NNS
cord-304876-txaoz7oh	175	18	within	within	IN
cord-304876-txaoz7oh	175	19	the	the	DT
cord-304876-txaoz7oh	175	20	genome	genome	NN
cord-304876-txaoz7oh	175	21	.	.	.
cord-304876-txaoz7oh	176	1	57	57	CD
cord-304876-txaoz7oh	177	1	The	the	DT
cord-304876-txaoz7oh	177	2	genome	genome	NN
cord-304876-txaoz7oh	177	3	of	of	IN
cord-304876-txaoz7oh	177	4	RSV	RSV	NNP
cord-304876-txaoz7oh	177	5	is	be	VBZ
cord-304876-txaoz7oh	177	6	approximately	approximately	RB
cord-304876-txaoz7oh	177	7	15	15	CD
cord-304876-txaoz7oh	177	8	kilobases	kilobase	NNS
cord-304876-txaoz7oh	177	9	long	long	RB
cord-304876-txaoz7oh	177	10	and	and	CC
cord-304876-txaoz7oh	177	11	is	be	VBZ
cord-304876-txaoz7oh	177	12	transcribed	transcribe	VBN
cord-304876-txaoz7oh	177	13	into	into	IN
cord-304876-txaoz7oh	177	14	capped	capped	JJ
cord-304876-txaoz7oh	177	15	and	and	CC
cord-304876-txaoz7oh	177	16	poly	poly	NN
cord-304876-txaoz7oh	177	17	-	-	HYPH
cord-304876-txaoz7oh	177	18	adenylated	adenylate	VBN
cord-304876-txaoz7oh	177	19	mRNAs	mRNAs	NNPS
cord-304876-txaoz7oh	177	20	.	.	.
cord-304876-txaoz7oh	178	1	58	58	CD
cord-304876-txaoz7oh	179	1	The	the	DT
cord-304876-txaoz7oh	179	2	HMPV	HMPV	NNP
cord-304876-txaoz7oh	179	3	genome	genome	NN
cord-304876-txaoz7oh	179	4	is	be	VBZ
cord-304876-txaoz7oh	179	5	13	13	CD
cord-304876-txaoz7oh	179	6	kilobases	kilobase	NNS
cord-304876-txaoz7oh	179	7	long	long	RB
cord-304876-txaoz7oh	179	8	.	.	.
cord-304876-txaoz7oh	180	1	Current	current	JJ
cord-304876-txaoz7oh	180	2	understanding	understanding	NN
cord-304876-txaoz7oh	180	3	of	of	IN
cord-304876-txaoz7oh	180	4	HMPV	hmpv	NN
cord-304876-txaoz7oh	180	5	transcription	transcription	NN
cord-304876-txaoz7oh	180	6	is	be	VBZ
cord-304876-txaoz7oh	180	7	based	base	VBN
cord-304876-txaoz7oh	180	8	on	on	IN
cord-304876-txaoz7oh	180	9	knowledge	knowledge	NN
cord-304876-txaoz7oh	180	10	gained	gain	VBN
cord-304876-txaoz7oh	180	11	from	from	IN
cord-304876-txaoz7oh	180	12	the	the	DT
cord-304876-txaoz7oh	180	13	more	more	RBR
cord-304876-txaoz7oh	180	14	extensive	extensive	JJ
cord-304876-txaoz7oh	180	15	characterization	characterization	NN
cord-304876-txaoz7oh	180	16	of	of	IN
cord-304876-txaoz7oh	180	17	RSV	RSV	NNP
cord-304876-txaoz7oh	180	18	transcription	transcription	NN
cord-304876-txaoz7oh	180	19	,	,	,
cord-304876-txaoz7oh	180	20	which	which	WDT
cord-304876-txaoz7oh	180	21	is	be	VBZ
cord-304876-txaoz7oh	180	22	the	the	DT
cord-304876-txaoz7oh	180	23	focus	focus	NN
cord-304876-txaoz7oh	180	24	here	here	RB
cord-304876-txaoz7oh	180	25	.	.	.
cord-304876-txaoz7oh	181	1	At	at	IN
cord-304876-txaoz7oh	181	2	the	the	DT
cord-304876-txaoz7oh	181	3	beginning	beginning	NN
cord-304876-txaoz7oh	181	4	and	and	CC
cord-304876-txaoz7oh	181	5	end	end	NN
cord-304876-txaoz7oh	181	6	of	of	IN
cord-304876-txaoz7oh	181	7	each	each	DT
cord-304876-txaoz7oh	181	8	viral	viral	JJ
cord-304876-txaoz7oh	181	9	gene	gene	NN
cord-304876-txaoz7oh	181	10	lies	lie	VBZ
cord-304876-txaoz7oh	181	11	a	a	DT
cord-304876-txaoz7oh	181	12	conserved	conserve	VBN
cord-304876-txaoz7oh	181	13	region	region	NN
cord-304876-txaoz7oh	181	14	(	(	-LRB-
cord-304876-txaoz7oh	181	15	CR	CR	NNP
cord-304876-txaoz7oh	181	16	)	)	-RRB-
cord-304876-txaoz7oh	181	17	of	of	IN
cord-304876-txaoz7oh	181	18	9	9	CD
cord-304876-txaoz7oh	181	19	-	-	SYM
cord-304876-txaoz7oh	181	20	10	10	CD
cord-304876-txaoz7oh	181	21	nucleotides	nucleotide	NNS
cord-304876-txaoz7oh	181	22	and	and	CC
cord-304876-txaoz7oh	181	23	12	12	CD
cord-304876-txaoz7oh	181	24	-	-	SYM
cord-304876-txaoz7oh	181	25	13	13	CD
cord-304876-txaoz7oh	181	26	nucleotides	nucleotide	NNS
cord-304876-txaoz7oh	181	27	,	,	,
cord-304876-txaoz7oh	181	28	respectively	respectively	RB
cord-304876-txaoz7oh	181	29	.	.	.
cord-304876-txaoz7oh	182	1	These	these	DT
cord-304876-txaoz7oh	182	2	are	be	VBP
cord-304876-txaoz7oh	182	3	termed	term	VBN
cord-304876-txaoz7oh	182	4	the	the	DT
cord-304876-txaoz7oh	182	5	gene	gene	NN
cord-304876-txaoz7oh	182	6	start	start	NN
cord-304876-txaoz7oh	182	7	(	(	-LRB-
cord-304876-txaoz7oh	182	8	gs	gs	NNP
cord-304876-txaoz7oh	182	9	)	)	-RRB-
cord-304876-txaoz7oh	182	10	and	and	CC
cord-304876-txaoz7oh	182	11	gene	gene	NN
cord-304876-txaoz7oh	182	12	end	end	NN
cord-304876-txaoz7oh	182	13	(	(	-LRB-
cord-304876-txaoz7oh	182	14	ge	ge	NNP
cord-304876-txaoz7oh	182	15	)	)	-RRB-
cord-304876-txaoz7oh	182	16	signals	signal	VBZ
cord-304876-txaoz7oh	182	17	with	with	IN
cord-304876-txaoz7oh	182	18	an	an	DT
cord-304876-txaoz7oh	182	19	intergenic	intergenic	JJ
cord-304876-txaoz7oh	182	20	,	,	,
cord-304876-txaoz7oh	182	21	non	non	JJ
cord-304876-txaoz7oh	182	22	-	-	JJ
cord-304876-txaoz7oh	182	23	transcribed	transcribe	VBN
cord-304876-txaoz7oh	182	24	region	region	NN
cord-304876-txaoz7oh	182	25	between	between	IN
cord-304876-txaoz7oh	182	26	these	these	DT
cord-304876-txaoz7oh	182	27	genes	gene	NNS
cord-304876-txaoz7oh	182	28	.	.	.
cord-304876-txaoz7oh	183	1	At	at	IN
cord-304876-txaoz7oh	183	2	the	the	DT
cord-304876-txaoz7oh	183	3	3	3	CD
cord-304876-txaoz7oh	183	4	0	0	CD
cord-304876-txaoz7oh	183	5	side	side	NN
cord-304876-txaoz7oh	183	6	of	of	IN
cord-304876-txaoz7oh	183	7	the	the	DT
cord-304876-txaoz7oh	183	8	genome	genome	NN
cord-304876-txaoz7oh	183	9	,	,	,
cord-304876-txaoz7oh	183	10	prior	prior	RB
cord-304876-txaoz7oh	183	11	to	to	IN
cord-304876-txaoz7oh	183	12	the	the	DT
cord-304876-txaoz7oh	183	13	first	first	JJ
cord-304876-txaoz7oh	183	14	gene	gene	NN
cord-304876-txaoz7oh	183	15	,	,	,
cord-304876-txaoz7oh	183	16	is	be	VBZ
cord-304876-txaoz7oh	183	17	the	the	DT
cord-304876-txaoz7oh	183	18	leader	leader	NN
cord-304876-txaoz7oh	183	19	(	(	-LRB-
cord-304876-txaoz7oh	183	20	le	le	NNP
cord-304876-txaoz7oh	183	21	)	)	-RRB-
cord-304876-txaoz7oh	183	22	extragenic	extragenic	NNP
cord-304876-txaoz7oh	183	23	region	region	NN
cord-304876-txaoz7oh	183	24	and	and	CC
cord-304876-txaoz7oh	183	25	at	at	IN
cord-304876-txaoz7oh	183	26	the	the	DT
cord-304876-txaoz7oh	183	27	5	5	CD
cord-304876-txaoz7oh	183	28	0	0	CD
cord-304876-txaoz7oh	183	29	end	end	NN
cord-304876-txaoz7oh	183	30	is	be	VBZ
cord-304876-txaoz7oh	183	31	the	the	DT
cord-304876-txaoz7oh	183	32	trailer	trailer	NN
cord-304876-txaoz7oh	183	33	(	(	-LRB-
cord-304876-txaoz7oh	183	34	tr	tr	NNP
cord-304876-txaoz7oh	183	35	)	)	-RRB-
cord-304876-txaoz7oh	183	36	extragenic	extragenic	NNP
cord-304876-txaoz7oh	183	37	region	region	NN
cord-304876-txaoz7oh	183	38	.	.	.
cord-304876-txaoz7oh	184	1	The	the	DT
cord-304876-txaoz7oh	184	2	lengths	length	NNS
cord-304876-txaoz7oh	184	3	of	of	IN
cord-304876-txaoz7oh	184	4	these	these	DT
cord-304876-txaoz7oh	184	5	extragenic	extragenic	JJ
cord-304876-txaoz7oh	184	6	regions	region	NNS
cord-304876-txaoz7oh	184	7	can	can	MD
cord-304876-txaoz7oh	184	8	vary	vary	VB
cord-304876-txaoz7oh	184	9	based	base	VBN
cord-304876-txaoz7oh	184	10	on	on	IN
cord-304876-txaoz7oh	184	11	the	the	DT
cord-304876-txaoz7oh	184	12	virus	virus	NN
cord-304876-txaoz7oh	184	13	but	but	CC
cord-304876-txaoz7oh	184	14	in	in	IN
cord-304876-txaoz7oh	184	15	RSV	RSV	NNP
cord-304876-txaoz7oh	184	16	the	the	DT
cord-304876-txaoz7oh	184	17	le	le	NNP
cord-304876-txaoz7oh	184	18	region	region	NN
cord-304876-txaoz7oh	184	19	is	be	VBZ
cord-304876-txaoz7oh	184	20	44	44	CD
cord-304876-txaoz7oh	184	21	nucleotides	nucleotide	NNS
cord-304876-txaoz7oh	184	22	long	long	JJ
cord-304876-txaoz7oh	184	23	.	.	.
cord-304876-txaoz7oh	185	1	To	to	TO
cord-304876-txaoz7oh	185	2	transcribe	transcribe	VB
cord-304876-txaoz7oh	185	3	its	-PRON-	PRP$
cord-304876-txaoz7oh	185	4	RNA	RNA	NNP
cord-304876-txaoz7oh	185	5	,	,	,
cord-304876-txaoz7oh	185	6	the	the	DT
cord-304876-txaoz7oh	185	7	polymerase	polymerase	NN
cord-304876-txaoz7oh	185	8	initiates	initiate	VBZ
cord-304876-txaoz7oh	185	9	at	at	IN
cord-304876-txaoz7oh	185	10	the	the	DT
cord-304876-txaoz7oh	185	11	third	third	JJ
cord-304876-txaoz7oh	185	12	nucleotide	nucleotide	NN
cord-304876-txaoz7oh	185	13	to	to	TO
cord-304876-txaoz7oh	185	14	transcribe	transcribe	VB
cord-304876-txaoz7oh	185	15	a	a	DT
cord-304876-txaoz7oh	185	16	short	short	JJ
cord-304876-txaoz7oh	185	17	uncapped	uncapped	JJ
cord-304876-txaoz7oh	185	18	transcript	transcript	NN
cord-304876-txaoz7oh	185	19	of	of	IN
cord-304876-txaoz7oh	185	20	about	about	RB
cord-304876-txaoz7oh	185	21	25	25	CD
cord-304876-txaoz7oh	185	22	nucleotides	nucleotide	NNS
cord-304876-txaoz7oh	185	23	.	.	.
cord-304876-txaoz7oh	186	1	59	59	CD
cord-304876-txaoz7oh	187	1	This	this	DT
cord-304876-txaoz7oh	187	2	RNA	RNA	NNP
cord-304876-txaoz7oh	187	3	is	be	VBZ
cord-304876-txaoz7oh	187	4	released	release	VBN
cord-304876-txaoz7oh	187	5	but	but	CC
cord-304876-txaoz7oh	187	6	the	the	DT
cord-304876-txaoz7oh	187	7	polymerase	polymerase	NN
cord-304876-txaoz7oh	187	8	remains	remain	VBZ
cord-304876-txaoz7oh	187	9	affixed	affix	VBN
cord-304876-txaoz7oh	187	10	to	to	IN
cord-304876-txaoz7oh	187	11	the	the	DT
cord-304876-txaoz7oh	187	12	template	template	NN
cord-304876-txaoz7oh	187	13	where	where	WRB
cord-304876-txaoz7oh	187	14	it	-PRON-	PRP
cord-304876-txaoz7oh	187	15	proceeds	proceed	VBZ
cord-304876-txaoz7oh	187	16	along	along	IN
cord-304876-txaoz7oh	187	17	until	until	IN
cord-304876-txaoz7oh	187	18	it	-PRON-	PRP
cord-304876-txaoz7oh	187	19	encounters	encounter	VBZ
cord-304876-txaoz7oh	187	20	the	the	DT
cord-304876-txaoz7oh	187	21	gs	gs	NNP
cord-304876-txaoz7oh	187	22	signal	signal	NN
cord-304876-txaoz7oh	187	23	for	for	IN
cord-304876-txaoz7oh	187	24	the	the	DT
cord-304876-txaoz7oh	187	25	first	first	JJ
cord-304876-txaoz7oh	187	26	gene	gene	NN
cord-304876-txaoz7oh	187	27	and	and	CC
cord-304876-txaoz7oh	187	28	subsequently	subsequently	RB
cord-304876-txaoz7oh	187	29	begins	begin	VBZ
cord-304876-txaoz7oh	187	30	RNA	RNA	NNP
cord-304876-txaoz7oh	187	31	synthesis	synthesis	NN
cord-304876-txaoz7oh	187	32	.	.	.
cord-304876-txaoz7oh	188	1	These	these	DT
cord-304876-txaoz7oh	188	2	mRNAs	mrna	NNS
cord-304876-txaoz7oh	188	3	are	be	VBP
cord-304876-txaoz7oh	188	4	modified	modify	VBN
cord-304876-txaoz7oh	188	5	with	with	IN
cord-304876-txaoz7oh	188	6	a	a	DT
cord-304876-txaoz7oh	188	7	5	5	CD
cord-304876-txaoz7oh	188	8	0	0	CD
cord-304876-txaoz7oh	188	9	methyl	methyl	NN
cord-304876-txaoz7oh	188	10	cap	cap	NN
cord-304876-txaoz7oh	188	11	and	and	CC
cord-304876-txaoz7oh	188	12	when	when	WRB
cord-304876-txaoz7oh	188	13	the	the	DT
cord-304876-txaoz7oh	188	14	ge	ge	NNP
cord-304876-txaoz7oh	188	15	signal	signal	NN
cord-304876-txaoz7oh	188	16	is	be	VBZ
cord-304876-txaoz7oh	188	17	reached	reach	VBN
cord-304876-txaoz7oh	188	18	,	,	,
cord-304876-txaoz7oh	188	19	a	a	DT
cord-304876-txaoz7oh	188	20	3	3	CD
cord-304876-txaoz7oh	188	21	0	0	CD
cord-304876-txaoz7oh	188	22	polyadenylated	polyadenylated	JJ
cord-304876-txaoz7oh	188	23	tail	tail	NN
cord-304876-txaoz7oh	188	24	is	be	VBZ
cord-304876-txaoz7oh	188	25	added	add	VBN
cord-304876-txaoz7oh	188	26	,	,	,
cord-304876-txaoz7oh	188	27	and	and	CC
cord-304876-txaoz7oh	188	28	the	the	DT
cord-304876-txaoz7oh	188	29	mRNA	mRNA	NNP
cord-304876-txaoz7oh	188	30	is	be	VBZ
cord-304876-txaoz7oh	188	31	released	release	VBN
cord-304876-txaoz7oh	188	32	.	.	.
cord-304876-txaoz7oh	189	1	The	the	DT
cord-304876-txaoz7oh	189	2	polymerase	polymerase	NN
cord-304876-txaoz7oh	189	3	then	then	RB
cord-304876-txaoz7oh	189	4	scans	scan	VBZ
cord-304876-txaoz7oh	189	5	for	for	IN
cord-304876-txaoz7oh	189	6	the	the	DT
cord-304876-txaoz7oh	189	7	next	next	JJ
cord-304876-txaoz7oh	189	8	gs	gs	NNP
cord-304876-txaoz7oh	189	9	region	region	NN
cord-304876-txaoz7oh	189	10	.	.	.
cord-304876-txaoz7oh	190	1	The	the	DT
cord-304876-txaoz7oh	190	2	genome	genome	NN
cord-304876-txaoz7oh	190	3	is	be	VBZ
cord-304876-txaoz7oh	190	4	replicated	replicate	VBN
cord-304876-txaoz7oh	190	5	starting	start	VBG
cord-304876-txaoz7oh	190	6	at	at	IN
cord-304876-txaoz7oh	190	7	the	the	DT
cord-304876-txaoz7oh	190	8	leader	leader	NN
cord-304876-txaoz7oh	190	9	promoter	promoter	NN
cord-304876-txaoz7oh	190	10	in	in	IN
cord-304876-txaoz7oh	190	11	a	a	DT
cord-304876-txaoz7oh	190	12	processive	processive	JJ
cord-304876-txaoz7oh	190	13	manner	manner	NN
cord-304876-txaoz7oh	190	14	to	to	TO
cord-304876-txaoz7oh	190	15	yield	yield	VB
cord-304876-txaoz7oh	190	16	a	a	DT
cord-304876-txaoz7oh	190	17	positive	positive	JJ
cord-304876-txaoz7oh	190	18	sense	sense	NN
cord-304876-txaoz7oh	190	19	antigenome	antigenome	NNP
cord-304876-txaoz7oh	190	20	RNA	RNA	NNP
cord-304876-txaoz7oh	190	21	.	.	.
cord-304876-txaoz7oh	191	1	The	the	DT
cord-304876-txaoz7oh	191	2	3	3	CD
cord-304876-txaoz7oh	191	3	0	0	CD
cord-304876-txaoz7oh	191	4	and	and	CC
cord-304876-txaoz7oh	191	5	5	5	CD
cord-304876-txaoz7oh	191	6	0	0	CD
cord-304876-txaoz7oh	191	7	ends	end	NNS
cord-304876-txaoz7oh	191	8	of	of	IN
cord-304876-txaoz7oh	191	9	the	the	DT
cord-304876-txaoz7oh	191	10	antigenome	antigenome	NN
cord-304876-txaoz7oh	191	11	contain	contain	VBP
cord-304876-txaoz7oh	191	12	the	the	DT
cord-304876-txaoz7oh	191	13	trailer	trailer	NN
cord-304876-txaoz7oh	191	14	and	and	CC
cord-304876-txaoz7oh	191	15	leader	leader	NN
cord-304876-txaoz7oh	191	16	complement	complement	NN
cord-304876-txaoz7oh	191	17	.	.	.
cord-304876-txaoz7oh	192	1	The	the	DT
cord-304876-txaoz7oh	192	2	trailer	trailer	NN
cord-304876-txaoz7oh	192	3	complement	complement	NN
cord-304876-txaoz7oh	192	4	ultimately	ultimately	RB
cord-304876-txaoz7oh	192	5	directs	direct	VBZ
cord-304876-txaoz7oh	192	6	genome	genome	NN
cord-304876-txaoz7oh	192	7	RNA	rna	NN
cord-304876-txaoz7oh	192	8	synthesis	synthesis	NN
cord-304876-txaoz7oh	192	9	.	.	.
cord-304876-txaoz7oh	193	1	The	the	DT
cord-304876-txaoz7oh	193	2	core	core	NN
cord-304876-txaoz7oh	193	3	RSV	rsv	NN
cord-304876-txaoz7oh	193	4	polymerase	polymerase	NN
cord-304876-txaoz7oh	193	5	consists	consist	VBZ
cord-304876-txaoz7oh	193	6	of	of	IN
cord-304876-txaoz7oh	193	7	a	a	DT
cord-304876-txaoz7oh	193	8	250	250	CD
cord-304876-txaoz7oh	193	9	kDa	kDa	NNPS
cord-304876-txaoz7oh	193	10	large	large	NN
cord-304876-txaoz7oh	193	11	(	(	-LRB-
cord-304876-txaoz7oh	193	12	L	l	NN
cord-304876-txaoz7oh	193	13	)	)	-RRB-
cord-304876-txaoz7oh	193	14	protein	protein	NN
cord-304876-txaoz7oh	193	15	of	of	IN
cord-304876-txaoz7oh	193	16	approximately	approximately	RB
cord-304876-txaoz7oh	193	17	2000	2000	CD
cord-304876-txaoz7oh	193	18	amino	amino	JJ
cord-304876-txaoz7oh	193	19	acids	acid	NNS
cord-304876-txaoz7oh	193	20	and	and	CC
cord-304876-txaoz7oh	193	21	a	a	DT
cord-304876-txaoz7oh	193	22	27	27	CD
cord-304876-txaoz7oh	193	23	kDa	kDa	NNS
cord-304876-txaoz7oh	193	24	phosphoprotein	phosphoprotein	NN
cord-304876-txaoz7oh	193	25	(	(	-LRB-
cord-304876-txaoz7oh	193	26	P	p	NN
cord-304876-txaoz7oh	193	27	)	)	-RRB-
cord-304876-txaoz7oh	193	28	that	that	WDT
cord-304876-txaoz7oh	193	29	synthesizes	synthesize	VBZ
cord-304876-txaoz7oh	193	30	an	an	DT
cord-304876-txaoz7oh	193	31	RNA	RNA	NNP
cord-304876-txaoz7oh	193	32	product	product	NN
cord-304876-txaoz7oh	193	33	upon	upon	IN
cord-304876-txaoz7oh	193	34	the	the	DT
cord-304876-txaoz7oh	193	35	addition	addition	NN
cord-304876-txaoz7oh	193	36	of	of	IN
cord-304876-txaoz7oh	193	37	an	an	DT
cord-304876-txaoz7oh	193	38	RNA	RNA	NNP
cord-304876-txaoz7oh	193	39	template	template	NN
cord-304876-txaoz7oh	193	40	.	.	.
cord-304876-txaoz7oh	194	1	[	[	-LRB-
cord-304876-txaoz7oh	194	2	59	59	CD
cord-304876-txaoz7oh	194	3	]	]	-RRB-
cord-304876-txaoz7oh	194	4	[	[	-LRB-
cord-304876-txaoz7oh	194	5	60	60	CD
cord-304876-txaoz7oh	194	6	]	]	-RRB-
cord-304876-txaoz7oh	194	7	[	[	-LRB-
cord-304876-txaoz7oh	194	8	61	61	CD
cord-304876-txaoz7oh	194	9	]	]	-RRB-
cord-304876-txaoz7oh	195	1	[	[	-LRB-
cord-304876-txaoz7oh	195	2	62	62	CD
cord-304876-txaoz7oh	195	3	]	]	-RRB-
cord-304876-txaoz7oh	196	1	The	the	DT
cord-304876-txaoz7oh	196	2	P	p	NN
cord-304876-txaoz7oh	196	3	protein	protein	NN
cord-304876-txaoz7oh	196	4	is	be	VBZ
cord-304876-txaoz7oh	196	5	thought	think	VBN
cord-304876-txaoz7oh	196	6	to	to	TO
cord-304876-txaoz7oh	196	7	act	act	VB
cord-304876-txaoz7oh	196	8	as	as	IN
cord-304876-txaoz7oh	196	9	a	a	DT
cord-304876-txaoz7oh	196	10	chaperone	chaperone	NN
cord-304876-txaoz7oh	196	11	to	to	TO
cord-304876-txaoz7oh	196	12	aid	aid	VB
cord-304876-txaoz7oh	196	13	in	in	IN
cord-304876-txaoz7oh	196	14	the	the	DT
cord-304876-txaoz7oh	196	15	stability	stability	NN
cord-304876-txaoz7oh	196	16	and	and	CC
cord-304876-txaoz7oh	196	17	expression	expression	NN
cord-304876-txaoz7oh	196	18	of	of	IN
cord-304876-txaoz7oh	196	19	the	the	DT
cord-304876-txaoz7oh	196	20	polymerase	polymerase	NN
cord-304876-txaoz7oh	196	21	.	.	.
cord-304876-txaoz7oh	197	1	During	during	IN
cord-304876-txaoz7oh	197	2	RNA	RNA	NNP
cord-304876-txaoz7oh	197	3	synthesis	synthesis	NN
cord-304876-txaoz7oh	197	4	,	,	,
cord-304876-txaoz7oh	197	5	the	the	DT
cord-304876-txaoz7oh	197	6	P	p	NN
cord-304876-txaoz7oh	197	7	protein	protein	NN
cord-304876-txaoz7oh	197	8	anchors	anchor	NNS
cord-304876-txaoz7oh	197	9	the	the	DT
cord-304876-txaoz7oh	197	10	L	L	NNP
cord-304876-txaoz7oh	197	11	protein	protein	NN
cord-304876-txaoz7oh	197	12	to	to	IN
cord-304876-txaoz7oh	197	13	the	the	DT
cord-304876-txaoz7oh	197	14	N	N	NNP
cord-304876-txaoz7oh	197	15	protein	protein	NN
cord-304876-txaoz7oh	197	16	and	and	CC
cord-304876-txaoz7oh	197	17	also	also	RB
cord-304876-txaoz7oh	197	18	binds	bind	VBZ
cord-304876-txaoz7oh	197	19	to	to	IN
cord-304876-txaoz7oh	197	20	the	the	DT
cord-304876-txaoz7oh	197	21	M2	M2	NNP
cord-304876-txaoz7oh	197	22	-	-	SYM
cord-304876-txaoz7oh	197	23	1	1	CD
cord-304876-txaoz7oh	197	24	transcription	transcription	NN
cord-304876-txaoz7oh	197	25	antitermination	antitermination	NN
cord-304876-txaoz7oh	197	26	factor	factor	NN
cord-304876-txaoz7oh	197	27	.	.	.
cord-304876-txaoz7oh	198	1	[	[	-LRB-
cord-304876-txaoz7oh	198	2	63	63	CD
cord-304876-txaoz7oh	198	3	]	]	-RRB-
cord-304876-txaoz7oh	198	4	[	[	-LRB-
cord-304876-txaoz7oh	198	5	64	64	CD
cord-304876-txaoz7oh	198	6	]	]	-RRB-
cord-304876-txaoz7oh	198	7	[	[	-LRB-
cord-304876-txaoz7oh	198	8	65	65	CD
cord-304876-txaoz7oh	198	9	]	]	-RRB-
cord-304876-txaoz7oh	199	1	[	[	-LRB-
cord-304876-txaoz7oh	199	2	66	66	CD
cord-304876-txaoz7oh	199	3	]	]	-RRB-
cord-304876-txaoz7oh	200	1	This	this	DT
cord-304876-txaoz7oh	200	2	matrix	matrix	NN
cord-304876-txaoz7oh	200	3	protein	protein	NN
cord-304876-txaoz7oh	200	4	,	,	,
cord-304876-txaoz7oh	200	5	M2	M2	NNP
cord-304876-txaoz7oh	200	6	-	-	HYPH
cord-304876-txaoz7oh	200	7	1	1	CD
cord-304876-txaoz7oh	200	8	,	,	,
cord-304876-txaoz7oh	200	9	serves	serve	VBZ
cord-304876-txaoz7oh	200	10	as	as	IN
cord-304876-txaoz7oh	200	11	an	an	DT
cord-304876-txaoz7oh	200	12	elongation	elongation	NN
cord-304876-txaoz7oh	200	13	factor	factor	NN
cord-304876-txaoz7oh	200	14	and	and	CC
cord-304876-txaoz7oh	200	15	is	be	VBZ
cord-304876-txaoz7oh	200	16	necessary	necessary	JJ
cord-304876-txaoz7oh	200	17	for	for	IN
cord-304876-txaoz7oh	200	18	the	the	DT
cord-304876-txaoz7oh	200	19	polymerase	polymerase	NN
cord-304876-txaoz7oh	200	20	to	to	TO
cord-304876-txaoz7oh	200	21	be	be	VB
cord-304876-txaoz7oh	200	22	fully	fully	RB
cord-304876-txaoz7oh	200	23	processive	processive	JJ
cord-304876-txaoz7oh	200	24	in	in	IN
cord-304876-txaoz7oh	200	25	producing	produce	VBG
cord-304876-txaoz7oh	200	26	long	long	JJ
cord-304876-txaoz7oh	200	27	mRNA	mRNA	NNP
cord-304876-txaoz7oh	200	28	products	product	NNS
cord-304876-txaoz7oh	200	29	.	.	.
cord-304876-txaoz7oh	201	1	67	67	CD
cord-304876-txaoz7oh	202	1	No	no	DT
cord-304876-txaoz7oh	202	2	structure	structure	NN
cord-304876-txaoz7oh	202	3	is	be	VBZ
cord-304876-txaoz7oh	202	4	available	available	JJ
cord-304876-txaoz7oh	202	5	for	for	IN
cord-304876-txaoz7oh	202	6	any	any	DT
cord-304876-txaoz7oh	202	7	L	L	NNP
cord-304876-txaoz7oh	202	8	protein	protein	NN
cord-304876-txaoz7oh	202	9	from	from	IN
cord-304876-txaoz7oh	202	10	the	the	DT
cord-304876-txaoz7oh	202	11	paramyxoviruses	paramyxovirus	NNS
cord-304876-txaoz7oh	202	12	and	and	CC
cord-304876-txaoz7oh	202	13	pneumoviruses	pneumoviruse	NNS
cord-304876-txaoz7oh	202	14	,	,	,
cord-304876-txaoz7oh	202	15	largely	largely	RB
cord-304876-txaoz7oh	202	16	due	due	JJ
cord-304876-txaoz7oh	202	17	to	to	IN
cord-304876-txaoz7oh	202	18	the	the	DT
cord-304876-txaoz7oh	202	19	size	size	NN
cord-304876-txaoz7oh	202	20	,	,	,
cord-304876-txaoz7oh	202	21	solubility	solubility	NN
cord-304876-txaoz7oh	202	22	,	,	,
cord-304876-txaoz7oh	202	23	and	and	CC
cord-304876-txaoz7oh	202	24	complexities	complexity	NNS
cord-304876-txaoz7oh	202	25	with	with	IN
cord-304876-txaoz7oh	202	26	yielding	yield	VBG
cord-304876-txaoz7oh	202	27	enough	enough	JJ
cord-304876-txaoz7oh	202	28	highly	highly	RB
cord-304876-txaoz7oh	202	29	pure	pure	JJ
cord-304876-txaoz7oh	202	30	protein	protein	NN
cord-304876-txaoz7oh	202	31	.	.	.
cord-304876-txaoz7oh	203	1	However	however	RB
cord-304876-txaoz7oh	203	2	,	,	,
cord-304876-txaoz7oh	203	3	the	the	DT
cord-304876-txaoz7oh	203	4	cryo	cryo	NN
cord-304876-txaoz7oh	203	5	-	-	HYPH
cord-304876-txaoz7oh	203	6	electron	electron	NN
cord-304876-txaoz7oh	203	7	microscopic	microscopic	NN
cord-304876-txaoz7oh	203	8	(	(	-LRB-
cord-304876-txaoz7oh	203	9	EM	EM	NNP
cord-304876-txaoz7oh	203	10	)	)	-RRB-
cord-304876-txaoz7oh	203	11	structure	structure	NN
cord-304876-txaoz7oh	203	12	of	of	IN
cord-304876-txaoz7oh	203	13	the	the	DT
cord-304876-txaoz7oh	203	14	L	L	NNP
cord-304876-txaoz7oh	203	15	-	-	HYPH
cord-304876-txaoz7oh	203	16	P	p	NN
cord-304876-txaoz7oh	203	17	complex	complex	NN
cord-304876-txaoz7oh	203	18	from	from	IN
cord-304876-txaoz7oh	203	19	a	a	DT
cord-304876-txaoz7oh	203	20	highly	highly	RB
cord-304876-txaoz7oh	203	21	similar	similar	JJ
cord-304876-txaoz7oh	203	22	virus	virus	NN
cord-304876-txaoz7oh	203	23	,	,	,
cord-304876-txaoz7oh	203	24	vesicular	vesicular	JJ
cord-304876-txaoz7oh	203	25	stomatitis	stomatitis	NN
cord-304876-txaoz7oh	203	26	virus	virus	NN
cord-304876-txaoz7oh	203	27	(	(	-LRB-
cord-304876-txaoz7oh	203	28	VSV	VSV	NNP
cord-304876-txaoz7oh	203	29	)	)	-RRB-
cord-304876-txaoz7oh	203	30	,	,	,
cord-304876-txaoz7oh	203	31	has	have	VBZ
cord-304876-txaoz7oh	203	32	recently	recently	RB
cord-304876-txaoz7oh	203	33	been	be	VBN
cord-304876-txaoz7oh	203	34	solved	solve	VBN
cord-304876-txaoz7oh	203	35	.	.	.
cord-304876-txaoz7oh	204	1	68	68	CD
cord-304876-txaoz7oh	204	2	VSV	VSV	NNP
cord-304876-txaoz7oh	204	3	is	be	VBZ
cord-304876-txaoz7oh	204	4	a	a	DT
cord-304876-txaoz7oh	204	5	non	non	JJ
cord-304876-txaoz7oh	204	6	-	-	JJ
cord-304876-txaoz7oh	204	7	segmented	segmented	JJ
cord-304876-txaoz7oh	204	8	,	,	,
cord-304876-txaoz7oh	204	9	negative	negative	JJ
cord-304876-txaoz7oh	204	10	strand	strand	NN
cord-304876-txaoz7oh	204	11	virus	virus	NN
cord-304876-txaoz7oh	204	12	from	from	IN
cord-304876-txaoz7oh	204	13	the	the	DT
cord-304876-txaoz7oh	204	14	Rhabdoviridae	Rhabdoviridae	NNP
cord-304876-txaoz7oh	204	15	family	family	NN
cord-304876-txaoz7oh	204	16	and	and	CC
cord-304876-txaoz7oh	204	17	given	give	VBN
cord-304876-txaoz7oh	204	18	the	the	DT
cord-304876-txaoz7oh	204	19	high	high	JJ
cord-304876-txaoz7oh	204	20	sequence	sequence	NN
cord-304876-txaoz7oh	204	21	conservation	conservation	NN
cord-304876-txaoz7oh	204	22	of	of	IN
cord-304876-txaoz7oh	204	23	the	the	DT
cord-304876-txaoz7oh	204	24	L	L	NNP
cord-304876-txaoz7oh	204	25	protein	protein	NN
cord-304876-txaoz7oh	204	26	,	,	,
cord-304876-txaoz7oh	204	27	the	the	DT
cord-304876-txaoz7oh	204	28	structure	structure	NN
cord-304876-txaoz7oh	204	29	of	of	IN
cord-304876-txaoz7oh	204	30	VSV	VSV	NNP
cord-304876-txaoz7oh	204	31	L	L	NNP
cord-304876-txaoz7oh	204	32	has	have	VBZ
cord-304876-txaoz7oh	204	33	provided	provide	VBN
cord-304876-txaoz7oh	204	34	important	important	JJ
cord-304876-txaoz7oh	204	35	structural	structural	JJ
cord-304876-txaoz7oh	204	36	insights	insight	NNS
cord-304876-txaoz7oh	204	37	.	.	.
cord-304876-txaoz7oh	205	1	The	the	DT
cord-304876-txaoz7oh	205	2	L	L	NNP
cord-304876-txaoz7oh	205	3	proteins	protein	NNS
cord-304876-txaoz7oh	205	4	of	of	IN
cord-304876-txaoz7oh	205	5	RSV	RSV	NNP
cord-304876-txaoz7oh	205	6	,	,	,
cord-304876-txaoz7oh	205	7	VSV	VSV	NNP
cord-304876-txaoz7oh	205	8	,	,	,
cord-304876-txaoz7oh	205	9	and	and	CC
cord-304876-txaoz7oh	205	10	other	other	JJ
cord-304876-txaoz7oh	205	11	related	related	JJ
cord-304876-txaoz7oh	205	12	negative	negative	JJ
cord-304876-txaoz7oh	205	13	sense	sense	NN
cord-304876-txaoz7oh	206	1	RNA	RNA	NNP
cord-304876-txaoz7oh	206	2	polymerases	polymerase	NNS
cord-304876-txaoz7oh	206	3	can	can	MD
cord-304876-txaoz7oh	206	4	be	be	VB
cord-304876-txaoz7oh	206	5	divided	divide	VBN
cord-304876-txaoz7oh	206	6	into	into	IN
cord-304876-txaoz7oh	206	7	six	six	CD
cord-304876-txaoz7oh	206	8	CR	cr	NN
cord-304876-txaoz7oh	206	9	.	.	.
cord-304876-txaoz7oh	207	1	69	69	CD
cord-304876-txaoz7oh	208	1	The	the	DT
cord-304876-txaoz7oh	208	2	first	first	JJ
cord-304876-txaoz7oh	208	3	three	three	CD
cord-304876-txaoz7oh	208	4	regions	region	NNS
cord-304876-txaoz7oh	208	5	(	(	-LRB-
cord-304876-txaoz7oh	208	6	CRI	CRI	NNP
cord-304876-txaoz7oh	208	7	-	-	HYPH
cord-304876-txaoz7oh	208	8	III	III	NNP
cord-304876-txaoz7oh	208	9	)	)	-RRB-
cord-304876-txaoz7oh	208	10	of	of	IN
cord-304876-txaoz7oh	208	11	VSV	VSV	NNP
cord-304876-txaoz7oh	208	12	generate	generate	VBP
cord-304876-txaoz7oh	208	13	a	a	DT
cord-304876-txaoz7oh	208	14	doughnut	doughnut	NN
cord-304876-txaoz7oh	208	15	-	-	HYPH
cord-304876-txaoz7oh	208	16	like	like	JJ
cord-304876-txaoz7oh	208	17	structure	structure	NN
cord-304876-txaoz7oh	208	18	in	in	IN
cord-304876-txaoz7oh	208	19	negative	negative	JJ
cord-304876-txaoz7oh	208	20	stain	stain	NN
cord-304876-txaoz7oh	208	21	EM	em	NN
cord-304876-txaoz7oh	208	22	and	and	CC
cord-304876-txaoz7oh	208	23	cryo	cryo	NN
cord-304876-txaoz7oh	208	24	-	-	HYPH
cord-304876-txaoz7oh	208	25	EM	em	NN
cord-304876-txaoz7oh	208	26	analysis	analysis	NN
cord-304876-txaoz7oh	208	27	.	.	.
cord-304876-txaoz7oh	209	1	68	68	CD
cord-304876-txaoz7oh	209	2	,	,	,
cord-304876-txaoz7oh	209	3	70	70	CD
cord-304876-txaoz7oh	210	1	The	the	DT
cord-304876-txaoz7oh	210	2	remaining	remain	VBG
cord-304876-txaoz7oh	210	3	CRs	CRs	NNPS
cord-304876-txaoz7oh	210	4	appear	appear	VBP
cord-304876-txaoz7oh	210	5	as	as	IN
cord-304876-txaoz7oh	210	6	globular	globular	JJ
cord-304876-txaoz7oh	210	7	appendages	appendage	NNS
cord-304876-txaoz7oh	210	8	on	on	IN
cord-304876-txaoz7oh	210	9	this	this	DT
cord-304876-txaoz7oh	210	10	doughnut	doughnut	NN
cord-304876-txaoz7oh	210	11	.	.	.
cord-304876-txaoz7oh	211	1	The	the	DT
cord-304876-txaoz7oh	211	2	doughnut	doughnut	NN
cord-304876-txaoz7oh	211	3	structure	structure	NN
cord-304876-txaoz7oh	211	4	adopts	adopt	VBZ
cord-304876-txaoz7oh	211	5	a	a	DT
cord-304876-txaoz7oh	211	6	classic	classic	JJ
cord-304876-txaoz7oh	211	7	right	right	RB
cord-304876-txaoz7oh	211	8	-	-	HYPH
cord-304876-txaoz7oh	211	9	handed	handed	JJ
cord-304876-txaoz7oh	211	10	configuration	configuration	NN
cord-304876-txaoz7oh	211	11	in	in	IN
cord-304876-txaoz7oh	211	12	the	the	DT
cord-304876-txaoz7oh	211	13	cryo	cryo	NN
cord-304876-txaoz7oh	211	14	-	-	HYPH
cord-304876-txaoz7oh	211	15	EM	EM	NNP
cord-304876-txaoz7oh	211	16	reconstruction	reconstruction	NN
cord-304876-txaoz7oh	211	17	composed	compose	VBN
cord-304876-txaoz7oh	211	18	of	of	IN
cord-304876-txaoz7oh	211	19	fingers	finger	NNS
cord-304876-txaoz7oh	211	20	,	,	,
cord-304876-txaoz7oh	211	21	palm	palm	NN
cord-304876-txaoz7oh	211	22	,	,	,
cord-304876-txaoz7oh	211	23	and	and	CC
cord-304876-txaoz7oh	211	24	thumb	thumb	NN
cord-304876-txaoz7oh	211	25	domains	domain	NNS
cord-304876-txaoz7oh	211	26	,	,	,
cord-304876-txaoz7oh	211	27	like	like	IN
cord-304876-txaoz7oh	211	28	other	other	JJ
cord-304876-txaoz7oh	211	29	polymerases	polymerase	NNS
cord-304876-txaoz7oh	211	30	(	(	-LRB-
cord-304876-txaoz7oh	211	31	see	see	VB
cord-304876-txaoz7oh	211	32	Figure	figure	NN
cord-304876-txaoz7oh	211	33	3	3	CD
cord-304876-txaoz7oh	211	34	)	)	-RRB-
cord-304876-txaoz7oh	211	35	.	.	.
cord-304876-txaoz7oh	212	1	The	the	DT
cord-304876-txaoz7oh	212	2	CRIV	CRIV	NNP
cord-304876-txaoz7oh	212	3	and	and	CC
cord-304876-txaoz7oh	212	4	CRV	CRV	NNP
cord-304876-txaoz7oh	212	5	contain	contain	VBP
cord-304876-txaoz7oh	212	6	conserved	conserved	JJ
cord-304876-txaoz7oh	212	7	residues	residue	NNS
cord-304876-txaoz7oh	212	8	and	and	CC
cord-304876-txaoz7oh	212	9	catalytic	catalytic	JJ
cord-304876-txaoz7oh	212	10	motifs	motif	NNS
cord-304876-txaoz7oh	212	11	necessary	necessary	JJ
cord-304876-txaoz7oh	212	12	for	for	IN
cord-304876-txaoz7oh	212	13	enzymatic	enzymatic	JJ
cord-304876-txaoz7oh	212	14	function	function	NN
cord-304876-txaoz7oh	212	15	.	.	.
cord-304876-txaoz7oh	213	1	Among	among	IN
cord-304876-txaoz7oh	213	2	these	these	DT
cord-304876-txaoz7oh	213	3	is	be	VBZ
cord-304876-txaoz7oh	213	4	the	the	DT
cord-304876-txaoz7oh	213	5	GxxT[n]HR	GxxT[n]HR	NNP
cord-304876-txaoz7oh	213	6	motif	motif	NN
cord-304876-txaoz7oh	213	7	,	,	,
cord-304876-txaoz7oh	213	8	a	a	DT
cord-304876-txaoz7oh	213	9	highly	highly	RB
cord-304876-txaoz7oh	213	10	conserved	conserve	VBN
cord-304876-txaoz7oh	213	11	set	set	NN
cord-304876-txaoz7oh	213	12	of	of	IN
cord-304876-txaoz7oh	213	13	residues	residue	NNS
cord-304876-txaoz7oh	213	14	necessary	necessary	JJ
cord-304876-txaoz7oh	213	15	for	for	IN
cord-304876-txaoz7oh	213	16	NTP	NTP	NNP
cord-304876-txaoz7oh	213	17	binding	binding	NN
cord-304876-txaoz7oh	213	18	and	and	CC
cord-304876-txaoz7oh	213	19	the	the	DT
cord-304876-txaoz7oh	213	20	HR	hr	NN
cord-304876-txaoz7oh	213	21	motif	motif	NN
cord-304876-txaoz7oh	213	22	,	,	,
cord-304876-txaoz7oh	213	23	which	which	WDT
cord-304876-txaoz7oh	213	24	forms	form	VBZ
cord-304876-txaoz7oh	213	25	covalent	covalent	JJ
cord-304876-txaoz7oh	213	26	histidine	histidine	NN
cord-304876-txaoz7oh	213	27	RNA	RNA	NNP
cord-304876-txaoz7oh	213	28	intermediate	intermediate	JJ
cord-304876-txaoz7oh	213	29	.	.	.
cord-304876-txaoz7oh	214	1	73	73	CD
cord-304876-txaoz7oh	215	1	Within	within	IN
cord-304876-txaoz7oh	215	2	CRVI	CRVI	NNP
cord-304876-txaoz7oh	215	3	there	there	EX
cord-304876-txaoz7oh	215	4	is	be	VBZ
cord-304876-txaoz7oh	215	5	a	a	DT
cord-304876-txaoz7oh	215	6	motif	motif	NN
cord-304876-txaoz7oh	215	7	with	with	IN
cord-304876-txaoz7oh	215	8	sequence	sequence	NN
cord-304876-txaoz7oh	215	9	similarity	similarity	NN
cord-304876-txaoz7oh	215	10	to	to	IN
cord-304876-txaoz7oh	215	11	the	the	DT
cord-304876-txaoz7oh	215	12	2	2	CD
cord-304876-txaoz7oh	215	13	0	0	CD
cord-304876-txaoz7oh	215	14	-O	-o	CD
cord-304876-txaoz7oh	215	15	-	-	HYPH
cord-304876-txaoz7oh	215	16	ribose	ribose	NN
cord-304876-txaoz7oh	215	17	methyltransferase	methyltransferase	NN
cord-304876-txaoz7oh	215	18	(	(	-LRB-
cord-304876-txaoz7oh	215	19	MTase	MTase	NNP
cord-304876-txaoz7oh	215	20	)	)	-RRB-
cord-304876-txaoz7oh	215	21	domain	domain	NN
cord-304876-txaoz7oh	215	22	,	,	,
cord-304876-txaoz7oh	215	23	which	which	WDT
cord-304876-txaoz7oh	215	24	has	have	VBZ
cord-304876-txaoz7oh	215	25	been	be	VBN
cord-304876-txaoz7oh	215	26	characterized	characterize	VBN
cord-304876-txaoz7oh	215	27	in	in	IN
cord-304876-txaoz7oh	215	28	the	the	DT
cord-304876-txaoz7oh	215	29	VSV	VSV	NNP
cord-304876-txaoz7oh	215	30	L	L	NNP
cord-304876-txaoz7oh	215	31	system	system	NN
cord-304876-txaoz7oh	215	32	.	.	.
cord-304876-txaoz7oh	216	1	74	74	CD
cord-304876-txaoz7oh	217	1	While	while	IN
cord-304876-txaoz7oh	217	2	it	-PRON-	PRP
cord-304876-txaoz7oh	217	3	is	be	VBZ
cord-304876-txaoz7oh	217	4	unknown	unknown	JJ
cord-304876-txaoz7oh	217	5	exactly	exactly	RB
cord-304876-txaoz7oh	217	6	how	how	WRB
cord-304876-txaoz7oh	217	7	similar	similar	JJ
cord-304876-txaoz7oh	217	8	the	the	DT
cord-304876-txaoz7oh	217	9	capping	cap	VBG
cord-304876-txaoz7oh	217	10	mechanism	mechanism	NN
cord-304876-txaoz7oh	217	11	of	of	IN
cord-304876-txaoz7oh	217	12	VSV	VSV	NNP
cord-304876-txaoz7oh	217	13	is	be	VBZ
cord-304876-txaoz7oh	217	14	to	to	IN
cord-304876-txaoz7oh	217	15	RSV	RSV	NNP
cord-304876-txaoz7oh	217	16	and	and	CC
cord-304876-txaoz7oh	217	17	HMPV	HMPV	NNP
cord-304876-txaoz7oh	217	18	,	,	,
cord-304876-txaoz7oh	217	19	the	the	DT
cord-304876-txaoz7oh	217	20	detailed	detailed	JJ
cord-304876-txaoz7oh	217	21	mechanism	mechanism	NN
cord-304876-txaoz7oh	217	22	of	of	IN
cord-304876-txaoz7oh	217	23	the	the	DT
cord-304876-txaoz7oh	217	24	VSV	VSV	NNP
cord-304876-txaoz7oh	217	25	capping	cap	VBG
cord-304876-txaoz7oh	217	26	biochemistry	biochemistry	NN
cord-304876-txaoz7oh	217	27	provides	provide	VBZ
cord-304876-txaoz7oh	217	28	insights	insight	NNS
cord-304876-txaoz7oh	217	29	.	.	.
cord-304876-txaoz7oh	218	1	The	the	DT
cord-304876-txaoz7oh	218	2	capping	capping	NN
cord-304876-txaoz7oh	218	3	of	of	IN
cord-304876-txaoz7oh	218	4	VSV	VSV	NNP
cord-304876-txaoz7oh	218	5	is	be	VBZ
cord-304876-txaoz7oh	218	6	unique	unique	JJ
cord-304876-txaoz7oh	218	7	in	in	IN
cord-304876-txaoz7oh	218	8	that	that	IN
cord-304876-txaoz7oh	218	9	it	-PRON-	PRP
cord-304876-txaoz7oh	218	10	is	be	VBZ
cord-304876-txaoz7oh	218	11	accomplished	accomplish	VBN
cord-304876-txaoz7oh	218	12	through	through	IN
cord-304876-txaoz7oh	218	13	an	an	DT
cord-304876-txaoz7oh	218	14	unconventional	unconventional	JJ
cord-304876-txaoz7oh	218	15	RNA	rna	NN
cord-304876-txaoz7oh	218	16	:	:	:
cord-304876-txaoz7oh	218	17	GDP	GDP	NNP
cord-304876-txaoz7oh	218	18	polyribonucleotidyltransferase	polyribonucleotidyltransferase	NN
cord-304876-txaoz7oh	218	19	(	(	-LRB-
cord-304876-txaoz7oh	218	20	PRNTase	prntase	NN
cord-304876-txaoz7oh	218	21	)	)	-RRB-
cord-304876-txaoz7oh	218	22	rather	rather	RB
cord-304876-txaoz7oh	218	23	than	than	IN
cord-304876-txaoz7oh	218	24	a	a	DT
cord-304876-txaoz7oh	218	25	guanyltransferase	guanyltransferase	NN
cord-304876-txaoz7oh	218	26	.	.	.
cord-304876-txaoz7oh	219	1	[	[	-LRB-
cord-304876-txaoz7oh	219	2	75	75	CD
cord-304876-txaoz7oh	219	3	]	]	-RRB-
cord-304876-txaoz7oh	219	4	[	[	-LRB-
cord-304876-txaoz7oh	219	5	76	76	CD
cord-304876-txaoz7oh	219	6	]	]	-RRB-
cord-304876-txaoz7oh	220	1	[	[	-LRB-
cord-304876-txaoz7oh	220	2	77	77	CD
cord-304876-txaoz7oh	220	3	]	]	-RRB-
cord-304876-txaoz7oh	221	1	The	the	DT
cord-304876-txaoz7oh	221	2	VSV	VSV	NNP
cord-304876-txaoz7oh	221	3	capping	capping	NN
cord-304876-txaoz7oh	221	4	occurs	occur	VBZ
cord-304876-txaoz7oh	221	5	in	in	IN
cord-304876-txaoz7oh	221	6	two	two	CD
cord-304876-txaoz7oh	221	7	parts	part	NNS
cord-304876-txaoz7oh	221	8	starting	start	VBG
cord-304876-txaoz7oh	221	9	with	with	IN
cord-304876-txaoz7oh	221	10	conversion	conversion	NN
cord-304876-txaoz7oh	221	11	of	of	IN
cord-304876-txaoz7oh	221	12	GTP	GTP	NNP
cord-304876-txaoz7oh	221	13	to	to	IN
cord-304876-txaoz7oh	221	14	GDP	GDP	NNP
cord-304876-txaoz7oh	221	15	through	through	IN
cord-304876-txaoz7oh	221	16	a	a	DT
cord-304876-txaoz7oh	221	17	GTPase	GTPase	NNP
cord-304876-txaoz7oh	221	18	followed	follow	VBN
cord-304876-txaoz7oh	221	19	by	by	IN
cord-304876-txaoz7oh	221	20	the	the	DT
cord-304876-txaoz7oh	221	21	covalent	covalent	JJ
cord-304876-txaoz7oh	221	22	attachment	attachment	NN
cord-304876-txaoz7oh	221	23	of	of	IN
cord-304876-txaoz7oh	221	24	a	a	DT
cord-304876-txaoz7oh	221	25	histidine	histidine	NN
cord-304876-txaoz7oh	221	26	to	to	IN
cord-304876-txaoz7oh	221	27	pRNA	prna	VB
cord-304876-txaoz7oh	221	28	to	to	TO
cord-304876-txaoz7oh	221	29	form	form	VB
cord-304876-txaoz7oh	221	30	a	a	DT
cord-304876-txaoz7oh	221	31	phosphamide	phosphamide	NN
cord-304876-txaoz7oh	221	32	bond	bond	NN
cord-304876-txaoz7oh	221	33	.	.	.
cord-304876-txaoz7oh	222	1	This	this	DT
cord-304876-txaoz7oh	222	2	GDP	GDP	NNP
cord-304876-txaoz7oh	222	3	then	then	RB
cord-304876-txaoz7oh	222	4	serves	serve	VBZ
cord-304876-txaoz7oh	222	5	as	as	IN
cord-304876-txaoz7oh	222	6	a	a	DT
cord-304876-txaoz7oh	222	7	nucleophile	nucleophile	NN
cord-304876-txaoz7oh	222	8	to	to	TO
cord-304876-txaoz7oh	222	9	attack	attack	VB
cord-304876-txaoz7oh	222	10	the	the	DT
cord-304876-txaoz7oh	222	11	pRNA	prna	NN
cord-304876-txaoz7oh	222	12	and	and	CC
cord-304876-txaoz7oh	222	13	results	result	NNS
cord-304876-txaoz7oh	222	14	in	in	IN
cord-304876-txaoz7oh	222	15	the	the	DT
cord-304876-txaoz7oh	222	16	release	release	NN
cord-304876-txaoz7oh	222	17	of	of	IN
cord-304876-txaoz7oh	222	18	the	the	DT
cord-304876-txaoz7oh	222	19	GpppRNA	GpppRNA	NNP
cord-304876-txaoz7oh	222	20	.	.	.
cord-304876-txaoz7oh	223	1	58	58	CD
cord-304876-txaoz7oh	224	1	The	the	DT
cord-304876-txaoz7oh	224	2	second	second	JJ
cord-304876-txaoz7oh	224	3	part	part	NN
cord-304876-txaoz7oh	224	4	of	of	IN
cord-304876-txaoz7oh	224	5	the	the	DT
cord-304876-txaoz7oh	224	6	reaction	reaction	NN
cord-304876-txaoz7oh	224	7	consists	consist	VBZ
cord-304876-txaoz7oh	224	8	of	of	IN
cord-304876-txaoz7oh	224	9	the	the	DT
cord-304876-txaoz7oh	224	10	MTase	MTase	NNP
cord-304876-txaoz7oh	224	11	reaction	reaction	NN
cord-304876-txaoz7oh	224	12	,	,	,
cord-304876-txaoz7oh	224	13	which	which	WDT
cord-304876-txaoz7oh	224	14	uses	use	VBZ
cord-304876-txaoz7oh	224	15	S	s	NN
cord-304876-txaoz7oh	224	16	-	-	HYPH
cord-304876-txaoz7oh	224	17	adenosylmethionine	adenosylmethionine	NN
cord-304876-txaoz7oh	224	18	to	to	TO
cord-304876-txaoz7oh	224	19	methylate	methylate	VB
cord-304876-txaoz7oh	224	20	nitrogen	nitrogen	NN
cord-304876-txaoz7oh	224	21	7	7	CD
cord-304876-txaoz7oh	224	22	and	and	CC
cord-304876-txaoz7oh	224	23	the	the	DT
cord-304876-txaoz7oh	224	24	2	2	CD
cord-304876-txaoz7oh	224	25	0	0	CD
cord-304876-txaoz7oh	224	26	-oxygen	-oxygen	NN
cord-304876-txaoz7oh	224	27	of	of	IN
cord-304876-txaoz7oh	224	28	the	the	DT
cord-304876-txaoz7oh	224	29	cap	cap	NN
cord-304876-txaoz7oh	224	30	.	.	.
cord-304876-txaoz7oh	225	1	A	a	DT
cord-304876-txaoz7oh	225	2	recent	recent	JJ
cord-304876-txaoz7oh	225	3	crystal	crystal	NN
cord-304876-txaoz7oh	225	4	structure	structure	NN
cord-304876-txaoz7oh	225	5	of	of	IN
cord-304876-txaoz7oh	225	6	the	the	DT
cord-304876-txaoz7oh	225	7	MTase	MTase	NNP
cord-304876-txaoz7oh	225	8	domain	domain	NN
cord-304876-txaoz7oh	225	9	from	from	IN
cord-304876-txaoz7oh	225	10	HMPV	HMPV	NNP
cord-304876-txaoz7oh	225	11	has	have	VBZ
cord-304876-txaoz7oh	225	12	provided	provide	VBN
cord-304876-txaoz7oh	225	13	additional	additional	JJ
cord-304876-txaoz7oh	225	14	clues	clue	NNS
cord-304876-txaoz7oh	225	15	into	into	IN
cord-304876-txaoz7oh	225	16	this	this	DT
cord-304876-txaoz7oh	225	17	reaction	reaction	NN
cord-304876-txaoz7oh	225	18	(	(	-LRB-
cord-304876-txaoz7oh	225	19	see	see	VB
cord-304876-txaoz7oh	225	20	Figure	figure	NN
cord-304876-txaoz7oh	225	21	3	3	CD
cord-304876-txaoz7oh	225	22	)	)	-RRB-
cord-304876-txaoz7oh	225	23	.	.	.
cord-304876-txaoz7oh	226	1	72	72	CD
cord-304876-txaoz7oh	227	1	A	a	DT
cord-304876-txaoz7oh	227	2	406-residue	406-residue	CD
cord-304876-txaoz7oh	227	3	fragment	fragment	NN
cord-304876-txaoz7oh	227	4	was	be	VBD
cord-304876-txaoz7oh	227	5	expressed	express	VBN
cord-304876-txaoz7oh	227	6	,	,	,
cord-304876-txaoz7oh	227	7	consisting	consist	VBG
cord-304876-txaoz7oh	227	8	of	of	IN
cord-304876-txaoz7oh	227	9	the	the	DT
cord-304876-txaoz7oh	227	10	CR	CR	NNP
cord-304876-txaoz7oh	227	11	-	-	HYPH
cord-304876-txaoz7oh	227	12	IV	IV	NNP
cord-304876-txaoz7oh	227	13	containing	contain	VBG
cord-304876-txaoz7oh	227	14	the	the	DT
cord-304876-txaoz7oh	227	15	putative	putative	JJ
cord-304876-txaoz7oh	227	16	MTase	mtase	NN
cord-304876-txaoz7oh	227	17	with	with	IN
cord-304876-txaoz7oh	227	18	an	an	DT
cord-304876-txaoz7oh	227	19	additional	additional	JJ
cord-304876-txaoz7oh	227	20	C	c	NN
cord-304876-txaoz7oh	227	21	-	-	HYPH
cord-304876-txaoz7oh	227	22	terminal	terminal	NN
cord-304876-txaoz7oh	227	23	K	K	NNP
cord-304876-txaoz7oh	227	24	-	-	HYPH
cord-304876-txaoz7oh	227	25	K	K	NNP
cord-304876-txaoz7oh	227	26	-	-	HYPH
cord-304876-txaoz7oh	227	27	G	g	NN
cord-304876-txaoz7oh	227	28	motif	motif	NN
cord-304876-txaoz7oh	227	29	(	(	-LRB-
cord-304876-txaoz7oh	227	30	termed	term	VBN
cord-304876-txaoz7oh	227	31	CR	cr	NN
cord-304876-txaoz7oh	227	32	-	-	HYPH
cord-304876-txaoz7oh	227	33	VIþ	VIþ	NNP
cord-304876-txaoz7oh	227	34	)	)	-RRB-
cord-304876-txaoz7oh	227	35	.	.	.
cord-304876-txaoz7oh	228	1	With	with	IN
cord-304876-txaoz7oh	228	2	the	the	DT
cord-304876-txaoz7oh	228	3	exception	exception	NN
cord-304876-txaoz7oh	228	4	of	of	IN
cord-304876-txaoz7oh	228	5	the	the	DT
cord-304876-txaoz7oh	228	6	K	K	NNP
cord-304876-txaoz7oh	228	7	-	-	HYPH
cord-304876-txaoz7oh	228	8	K	K	NNP
cord-304876-txaoz7oh	228	9	-	-	HYPH
cord-304876-txaoz7oh	228	10	G	g	NN
cord-304876-txaoz7oh	228	11	motif	motif	NN
cord-304876-txaoz7oh	228	12	,	,	,
cord-304876-txaoz7oh	228	13	the	the	DT
cord-304876-txaoz7oh	228	14	fold	fold	NN
cord-304876-txaoz7oh	228	15	of	of	IN
cord-304876-txaoz7oh	228	16	the	the	DT
cord-304876-txaoz7oh	228	17	HMPV	hmpv	NN
cord-304876-txaoz7oh	228	18	MTase	MTase	NNP
cord-304876-txaoz7oh	228	19	domain	domain	NN
cord-304876-txaoz7oh	228	20	indicates	indicate	VBZ
cord-304876-txaoz7oh	228	21	a	a	DT
cord-304876-txaoz7oh	228	22	conserved	conserve	VBN
cord-304876-txaoz7oh	228	23	fold	fold	NN
cord-304876-txaoz7oh	228	24	compared	compare	VBN
cord-304876-txaoz7oh	228	25	to	to	IN
cord-304876-txaoz7oh	228	26	VSV	VSV	NNP
cord-304876-txaoz7oh	228	27	.	.	.
cord-304876-txaoz7oh	229	1	72	72	CD
cord-304876-txaoz7oh	230	1	While	while	IN
cord-304876-txaoz7oh	230	2	the	the	DT
cord-304876-txaoz7oh	230	3	CR	cr	NN
cord-304876-txaoz7oh	230	4	-	-	HYPH
cord-304876-txaoz7oh	230	5	VIþ	VIþ	NNP
cord-304876-txaoz7oh	230	6	was	be	VBD
cord-304876-txaoz7oh	230	7	active	active	JJ
cord-304876-txaoz7oh	230	8	,	,	,
cord-304876-txaoz7oh	230	9	the	the	DT
cord-304876-txaoz7oh	230	10	reaction	reaction	NN
cord-304876-txaoz7oh	230	11	rate	rate	NN
cord-304876-txaoz7oh	230	12	was	be	VBD
cord-304876-txaoz7oh	231	1	very	very	RB
cord-304876-txaoz7oh	231	2	slow	slow	JJ
cord-304876-txaoz7oh	231	3	and	and	CC
cord-304876-txaoz7oh	231	4	structural	structural	JJ
cord-304876-txaoz7oh	231	5	and	and	CC
cord-304876-txaoz7oh	231	6	biochemical	biochemical	JJ
cord-304876-txaoz7oh	231	7	results	result	NNS
cord-304876-txaoz7oh	231	8	did	do	VBD
cord-304876-txaoz7oh	231	9	not	not	RB
cord-304876-txaoz7oh	231	10	clearly	clearly	RB
cord-304876-txaoz7oh	231	11	identify	identify	VB
cord-304876-txaoz7oh	231	12	active	active	JJ
cord-304876-txaoz7oh	231	13	site	site	NN
cord-304876-txaoz7oh	231	14	residues	residue	NNS
cord-304876-txaoz7oh	231	15	.	.	.
cord-304876-txaoz7oh	232	1	This	this	DT
cord-304876-txaoz7oh	232	2	suggests	suggest	VBZ
cord-304876-txaoz7oh	232	3	that	that	IN
cord-304876-txaoz7oh	232	4	MTase	MTase	NNP
cord-304876-txaoz7oh	232	5	requires	require	VBZ
cord-304876-txaoz7oh	232	6	other	other	JJ
cord-304876-txaoz7oh	232	7	co	co	NNS
cord-304876-txaoz7oh	232	8	-	-	NNS
cord-304876-txaoz7oh	232	9	factors	factor	NNS
cord-304876-txaoz7oh	232	10	or	or	CC
cord-304876-txaoz7oh	232	11	additional	additional	JJ
cord-304876-txaoz7oh	232	12	parts	part	NNS
cord-304876-txaoz7oh	232	13	of	of	IN
cord-304876-txaoz7oh	232	14	the	the	DT
cord-304876-txaoz7oh	232	15	L	L	NNP
cord-304876-txaoz7oh	232	16	protein	protein	NN
cord-304876-txaoz7oh	232	17	to	to	TO
cord-304876-txaoz7oh	232	18	be	be	VB
cord-304876-txaoz7oh	232	19	catalytic	catalytic	JJ
cord-304876-txaoz7oh	232	20	.	.	.
cord-304876-txaoz7oh	233	1	Human	human	JJ
cord-304876-txaoz7oh	233	2	rhinovirus	rhinovirus	NN
cord-304876-txaoz7oh	233	3	(	(	-LRB-
cord-304876-txaoz7oh	233	4	HRV	HRV	NNP
cord-304876-txaoz7oh	233	5	)	)	-RRB-
cord-304876-txaoz7oh	233	6	,	,	,
cord-304876-txaoz7oh	233	7	enterovirus	enterovirus	NN
cord-304876-txaoz7oh	233	8	71	71	CD
cord-304876-txaoz7oh	233	9	(	(	-LRB-
cord-304876-txaoz7oh	233	10	EV71	EV71	NNP
cord-304876-txaoz7oh	233	11	)	)	-RRB-
cord-304876-txaoz7oh	233	12	,	,	,
cord-304876-txaoz7oh	233	13	and	and	CC
cord-304876-txaoz7oh	233	14	poliovirus	poliovirus	NN
cord-304876-txaoz7oh	233	15	(	(	-LRB-
cord-304876-txaoz7oh	233	16	PV	PV	NNP
cord-304876-txaoz7oh	233	17	)	)	-RRB-
cord-304876-txaoz7oh	233	18	are	be	VBP
cord-304876-txaoz7oh	233	19	nonenveloped	nonenvelope	VBN
cord-304876-txaoz7oh	233	20	,	,	,
cord-304876-txaoz7oh	233	21	positive	positive	JJ
cord-304876-txaoz7oh	233	22	strand	strand	NN
cord-304876-txaoz7oh	233	23	RNA	RNA	NNP
cord-304876-txaoz7oh	233	24	viruses	virus	NNS
cord-304876-txaoz7oh	233	25	and	and	CC
cord-304876-txaoz7oh	233	26	are	be	VBP
cord-304876-txaoz7oh	233	27	all	all	DT
cord-304876-txaoz7oh	233	28	members	member	NNS
cord-304876-txaoz7oh	233	29	of	of	IN
cord-304876-txaoz7oh	233	30	the	the	DT
cord-304876-txaoz7oh	233	31	Picornaviridae	Picornaviridae	NNP
cord-304876-txaoz7oh	233	32	family	family	NN
cord-304876-txaoz7oh	233	33	.	.	.
cord-304876-txaoz7oh	234	1	Picornaviruses	Picornaviruses	NNP
cord-304876-txaoz7oh	234	2	replicate	replicate	VBP
cord-304876-txaoz7oh	234	3	their	-PRON-	PRP$
cord-304876-txaoz7oh	234	4	genome	genome	NN
cord-304876-txaoz7oh	234	5	using	use	VBG
cord-304876-txaoz7oh	234	6	an	an	DT
cord-304876-txaoz7oh	234	7	RdRp	RdRp	NNP
cord-304876-txaoz7oh	234	8	,	,	,
cord-304876-txaoz7oh	234	9	called	call	VBN
cord-304876-txaoz7oh	234	10	3D	3D	NNP
cord-304876-txaoz7oh	234	11	pol	pol	NN
cord-304876-txaoz7oh	234	12	.	.	.
cord-304876-txaoz7oh	235	1	78	78	CD
cord-304876-txaoz7oh	235	2	Replication	replication	NN
cord-304876-txaoz7oh	235	3	takes	take	VBZ
cord-304876-txaoz7oh	235	4	place	place	NN
cord-304876-txaoz7oh	235	5	in	in	IN
cord-304876-txaoz7oh	235	6	one	one	CD
cord-304876-txaoz7oh	235	7	of	of	IN
cord-304876-txaoz7oh	235	8	two	two	CD
cord-304876-txaoz7oh	235	9	forms	form	NNS
cord-304876-txaoz7oh	235	10	:	:	:
cord-304876-txaoz7oh	235	11	primer	primer	NN
cord-304876-txaoz7oh	235	12	-	-	HYPH
cord-304876-txaoz7oh	235	13	dependent	dependent	JJ
cord-304876-txaoz7oh	235	14	format	format	NN
cord-304876-txaoz7oh	235	15	or	or	CC
cord-304876-txaoz7oh	235	16	de	de	NNP
cord-304876-txaoz7oh	235	17	novo	novo	NNP
cord-304876-txaoz7oh	235	18	RNA	RNA	NNP
cord-304876-txaoz7oh	235	19	synthesis	synthesis	NN
cord-304876-txaoz7oh	235	20	.	.	.
cord-304876-txaoz7oh	236	1	79	79	CD
cord-304876-txaoz7oh	237	1	De	De	NNP
cord-304876-txaoz7oh	237	2	novo	novo	NNP
cord-304876-txaoz7oh	237	3	RNA	RNA	NNP
cord-304876-txaoz7oh	237	4	synthesis	synthesis	NN
cord-304876-txaoz7oh	237	5	,	,	,
cord-304876-txaoz7oh	237	6	which	which	WDT
cord-304876-txaoz7oh	237	7	uses	use	VBZ
cord-304876-txaoz7oh	237	8	a	a	DT
cord-304876-txaoz7oh	237	9	single	single	JJ
cord-304876-txaoz7oh	237	10	initiation	initiation	NN
cord-304876-txaoz7oh	237	11	nucleotide	nucleotide	NN
cord-304876-txaoz7oh	237	12	,	,	,
cord-304876-txaoz7oh	237	13	gives	give	VBZ
cord-304876-txaoz7oh	237	14	the	the	DT
cord-304876-txaoz7oh	237	15	3	3	CD
cord-304876-txaoz7oh	237	16	0	0	CD
cord-304876-txaoz7oh	237	17	-hydroxyl	-hydroxyl	CD
cord-304876-txaoz7oh	237	18	group	group	NN
cord-304876-txaoz7oh	237	19	for	for	IN
cord-304876-txaoz7oh	237	20	adding	add	VBG
cord-304876-txaoz7oh	237	21	the	the	DT
cord-304876-txaoz7oh	237	22	sequential	sequential	JJ
cord-304876-txaoz7oh	237	23	nucleotide	nucleotide	NN
cord-304876-txaoz7oh	237	24	whereas	whereas	IN
cord-304876-txaoz7oh	237	25	a	a	DT
cord-304876-txaoz7oh	237	26	primer	primer	NN
cord-304876-txaoz7oh	237	27	-	-	HYPH
cord-304876-txaoz7oh	237	28	dependent	dependent	JJ
cord-304876-txaoz7oh	237	29	format	format	NN
cord-304876-txaoz7oh	237	30	uses	use	VBZ
cord-304876-txaoz7oh	237	31	a	a	DT
cord-304876-txaoz7oh	237	32	protein	protein	NN
cord-304876-txaoz7oh	237	33	-	-	HYPH
cord-304876-txaoz7oh	237	34	based	base	VBN
cord-304876-txaoz7oh	237	35	primer	primer	NN
cord-304876-txaoz7oh	237	36	or	or	CC
cord-304876-txaoz7oh	237	37	an	an	DT
cord-304876-txaoz7oh	237	38	oligonucleotide	oligonucleotide	NN
cord-304876-txaoz7oh	237	39	for	for	IN
cord-304876-txaoz7oh	237	40	the	the	DT
cord-304876-txaoz7oh	237	41	hydroxyl	hydroxyl	NN
cord-304876-txaoz7oh	237	42	group	group	NN
cord-304876-txaoz7oh	237	43	donor	donor	NN
cord-304876-txaoz7oh	237	44	.	.	.
cord-304876-txaoz7oh	238	1	80	80	CD
cord-304876-txaoz7oh	239	1	The	the	DT
cord-304876-txaoz7oh	239	2	polymerases	polymerase	NNS
cord-304876-txaoz7oh	239	3	from	from	IN
cord-304876-txaoz7oh	239	4	the	the	DT
cord-304876-txaoz7oh	239	5	picornavirus	picornavirus	NNP
cord-304876-txaoz7oh	239	6	family	family	NN
cord-304876-txaoz7oh	239	7	only	only	RB
cord-304876-txaoz7oh	239	8	use	use	VBP
cord-304876-txaoz7oh	239	9	a	a	DT
cord-304876-txaoz7oh	239	10	protein	protein	NN
cord-304876-txaoz7oh	239	11	-	-	HYPH
cord-304876-txaoz7oh	239	12	primed	prime	VBN
cord-304876-txaoz7oh	239	13	mechanism	mechanism	NN
cord-304876-txaoz7oh	239	14	of	of	IN
cord-304876-txaoz7oh	239	15	initiation	initiation	NN
cord-304876-txaoz7oh	239	16	.	.	.
cord-304876-txaoz7oh	240	1	80	80	CD
cord-304876-txaoz7oh	240	2	,	,	,
cord-304876-txaoz7oh	240	3	81	81	CD
cord-304876-txaoz7oh	241	1	The	the	DT
cord-304876-txaoz7oh	241	2	3D	3d	JJ
cord-304876-txaoz7oh	241	3	pol	pol	NN
cord-304876-txaoz7oh	241	4	uses	use	VBZ
cord-304876-txaoz7oh	241	5	a	a	DT
cord-304876-txaoz7oh	241	6	small	small	JJ
cord-304876-txaoz7oh	241	7	viral	viral	JJ
cord-304876-txaoz7oh	241	8	peptide	peptide	NN
cord-304876-txaoz7oh	241	9	(	(	-LRB-
cord-304876-txaoz7oh	241	10	VPg	VPg	NNS
cord-304876-txaoz7oh	241	11	)	)	-RRB-
cord-304876-txaoz7oh	241	12	to	to	TO
cord-304876-txaoz7oh	241	13	initiate	initiate	VB
cord-304876-txaoz7oh	241	14	both	both	DT
cord-304876-txaoz7oh	241	15	plus	plus	NN
cord-304876-txaoz7oh	241	16	and	and	CC
cord-304876-txaoz7oh	241	17	minus	minus	CC
cord-304876-txaoz7oh	241	18	RNA	RNA	NNP
cord-304876-txaoz7oh	241	19	synthesis	synthesis	NN
cord-304876-txaoz7oh	241	20	in	in	IN
cord-304876-txaoz7oh	241	21	vivo	vivo	NN
cord-304876-txaoz7oh	241	22	,	,	,
cord-304876-txaoz7oh	241	23	making	make	VBG
cord-304876-txaoz7oh	241	24	Picornaviridae	Picornaviridae	NNP
cord-304876-txaoz7oh	241	25	unique	unique	JJ
cord-304876-txaoz7oh	241	26	in	in	IN
cord-304876-txaoz7oh	241	27	their	-PRON-	PRP$
cord-304876-txaoz7oh	241	28	initiation	initiation	NN
cord-304876-txaoz7oh	241	29	mechanism	mechanism	NN
cord-304876-txaoz7oh	241	30	.	.	.
cord-304876-txaoz7oh	242	1	78	78	CD
cord-304876-txaoz7oh	242	2	RNA	RNA	NNP
cord-304876-txaoz7oh	242	3	synthesis	synthesis	NN
cord-304876-txaoz7oh	242	4	is	be	VBZ
cord-304876-txaoz7oh	242	5	initiated	initiate	VBN
cord-304876-txaoz7oh	242	6	using	use	VBG
cord-304876-txaoz7oh	242	7	a	a	DT
cord-304876-txaoz7oh	242	8	highly	highly	RB
cord-304876-txaoz7oh	242	9	conserved	conserve	VBN
cord-304876-txaoz7oh	242	10	tyrosine	tyrosine	NN
cord-304876-txaoz7oh	242	11	residue	residue	NN
cord-304876-txaoz7oh	242	12	within	within	IN
cord-304876-txaoz7oh	242	13	VPg	VPg	NNS
cord-304876-txaoz7oh	242	14	using	use	VBG
cord-304876-txaoz7oh	242	15	cis	cis	NNP
cord-304876-txaoz7oh	242	16	-	-	HYPH
cord-304876-txaoz7oh	242	17	acting	act	VBG
cord-304876-txaoz7oh	242	18	replication	replication	NN
cord-304876-txaoz7oh	242	19	element	element	NN
cord-304876-txaoz7oh	242	20	as	as	IN
cord-304876-txaoz7oh	242	21	a	a	DT
cord-304876-txaoz7oh	242	22	template	template	NN
cord-304876-txaoz7oh	242	23	whose	whose	WP$
cord-304876-txaoz7oh	242	24	position	position	NN
cord-304876-txaoz7oh	242	25	varies	vary	VBZ
cord-304876-txaoz7oh	242	26	depending	depend	VBG
cord-304876-txaoz7oh	242	27	on	on	IN
cord-304876-txaoz7oh	242	28	the	the	DT
cord-304876-txaoz7oh	242	29	genus	genus	NN
cord-304876-txaoz7oh	242	30	.	.	.
cord-304876-txaoz7oh	243	1	78	78	CD
cord-304876-txaoz7oh	243	2	,	,	,
cord-304876-txaoz7oh	243	3	82	82	CD
cord-304876-txaoz7oh	244	1	The	the	DT
cord-304876-txaoz7oh	244	2	3D	3d	JJ
cord-304876-txaoz7oh	244	3	pol	pol	NN
cord-304876-txaoz7oh	244	4	aids	aids	NNP
cord-304876-txaoz7oh	244	5	in	in	IN
cord-304876-txaoz7oh	244	6	the	the	DT
cord-304876-txaoz7oh	244	7	binding	binding	NN
cord-304876-txaoz7oh	244	8	of	of	IN
cord-304876-txaoz7oh	244	9	two	two	CD
cord-304876-txaoz7oh	244	10	UMP	UMP	NNP
cord-304876-txaoz7oh	244	11	molecules	molecule	NNS
cord-304876-txaoz7oh	244	12	to	to	IN
cord-304876-txaoz7oh	244	13	the	the	DT
cord-304876-txaoz7oh	244	14	tyrosine	tyrosine	NN
cord-304876-txaoz7oh	244	15	hydroxyl	hydroxyl	NN
cord-304876-txaoz7oh	244	16	group	group	NN
cord-304876-txaoz7oh	244	17	of	of	IN
cord-304876-txaoz7oh	244	18	VPg	VPg	NNS
cord-304876-txaoz7oh	244	19	.	.	.
cord-304876-txaoz7oh	245	1	[	[	-LRB-
cord-304876-txaoz7oh	245	2	83	83	CD
cord-304876-txaoz7oh	245	3	]	]	-RRB-
cord-304876-txaoz7oh	245	4	[	[	-LRB-
cord-304876-txaoz7oh	245	5	84	84	CD
cord-304876-txaoz7oh	245	6	]	]	-RRB-
cord-304876-txaoz7oh	245	7	[	[	-LRB-
cord-304876-txaoz7oh	245	8	85	85	CD
cord-304876-txaoz7oh	245	9	]	]	-RRB-
cord-304876-txaoz7oh	246	1	The	the	DT
cord-304876-txaoz7oh	246	2	product	product	NN
cord-304876-txaoz7oh	246	3	of	of	IN
cord-304876-txaoz7oh	246	4	this	this	DT
cord-304876-txaoz7oh	246	5	reaction	reaction	NN
cord-304876-txaoz7oh	246	6	,	,	,
cord-304876-txaoz7oh	246	7	VPg	vpg	NN
cord-304876-txaoz7oh	246	8	-	-	HYPH
cord-304876-txaoz7oh	246	9	pU	pU	NNP
cord-304876-txaoz7oh	246	10	is	be	VBZ
cord-304876-txaoz7oh	246	11	then	then	RB
cord-304876-txaoz7oh	246	12	extended	extend	VBN
cord-304876-txaoz7oh	246	13	by	by	IN
cord-304876-txaoz7oh	246	14	an	an	DT
cord-304876-txaoz7oh	246	15	additional	additional	JJ
cord-304876-txaoz7oh	246	16	uridine	uridine	NN
cord-304876-txaoz7oh	246	17	to	to	TO
cord-304876-txaoz7oh	246	18	form	form	VB
cord-304876-txaoz7oh	246	19	VPg	VPg	NNS
cord-304876-txaoz7oh	246	20	-	-	:
cord-304876-txaoz7oh	246	21	pUpU.	pupu.	$
cord-304876-txaoz7oh	246	22	86	86	CD
cord-304876-txaoz7oh	247	1	The	the	DT
cord-304876-txaoz7oh	247	2	3D	3d	JJ
cord-304876-txaoz7oh	247	3	pol	pol	NN
cord-304876-txaoz7oh	247	4	is	be	VBZ
cord-304876-txaoz7oh	247	5	located	locate	VBN
cord-304876-txaoz7oh	247	6	at	at	IN
cord-304876-txaoz7oh	247	7	the	the	DT
cord-304876-txaoz7oh	247	8	C	C	NNP
cord-304876-txaoz7oh	247	9	-	-	HYPH
cord-304876-txaoz7oh	247	10	terminal	terminal	JJ
cord-304876-txaoz7oh	247	11	end	end	NN
cord-304876-txaoz7oh	247	12	of	of	IN
cord-304876-txaoz7oh	247	13	a	a	DT
cord-304876-txaoz7oh	247	14	longer	long	RBR
cord-304876-txaoz7oh	247	15	viral	viral	JJ
cord-304876-txaoz7oh	247	16	polyprotein	polyprotein	NN
cord-304876-txaoz7oh	247	17	of	of	IN
cord-304876-txaoz7oh	247	18	approximately	approximately	RB
cord-304876-txaoz7oh	247	19	250	250	CD
cord-304876-txaoz7oh	247	20	kDa	kDa	NNS
cord-304876-txaoz7oh	247	21	and	and	CC
cord-304876-txaoz7oh	247	22	the	the	DT
cord-304876-txaoz7oh	247	23	structures	structure	NNS
cord-304876-txaoz7oh	247	24	of	of	IN
cord-304876-txaoz7oh	247	25	3D	3D	NNP
cord-304876-txaoz7oh	247	26	pol	pol	NN
cord-304876-txaoz7oh	247	27	have	have	VBP
cord-304876-txaoz7oh	247	28	been	be	VBN
cord-304876-txaoz7oh	247	29	solved	solve	VBN
cord-304876-txaoz7oh	247	30	for	for	IN
cord-304876-txaoz7oh	247	31	EV71	EV71	NNP
cord-304876-txaoz7oh	247	32	,	,	,
cord-304876-txaoz7oh	247	33	HRV16	HRV16	NNP
cord-304876-txaoz7oh	247	34	,	,	,
cord-304876-txaoz7oh	247	35	and	and	CC
cord-304876-txaoz7oh	247	36	PV	PV	NNP
cord-304876-txaoz7oh	247	37	,	,	,
cord-304876-txaoz7oh	247	38	among	among	IN
cord-304876-txaoz7oh	247	39	many	many	JJ
cord-304876-txaoz7oh	247	40	others	other	NNS
cord-304876-txaoz7oh	247	41	.	.	.
cord-304876-txaoz7oh	248	1	[	[	-LRB-
cord-304876-txaoz7oh	248	2	86	86	CD
cord-304876-txaoz7oh	248	3	]	]	-RRB-
cord-304876-txaoz7oh	248	4	[	[	-LRB-
cord-304876-txaoz7oh	248	5	87	87	CD
cord-304876-txaoz7oh	248	6	]	]	-RRB-
cord-304876-txaoz7oh	248	7	[	[	-LRB-
cord-304876-txaoz7oh	248	8	88	88	CD
cord-304876-txaoz7oh	248	9	]	]	-RRB-
cord-304876-txaoz7oh	249	1	The	the	DT
cord-304876-txaoz7oh	249	2	structures	structure	NNS
cord-304876-txaoz7oh	249	3	of	of	IN
cord-304876-txaoz7oh	249	4	these	these	DT
cord-304876-txaoz7oh	249	5	polymerases	polymerase	NNS
cord-304876-txaoz7oh	249	6	are	be	VBP
cord-304876-txaoz7oh	249	7	largely	largely	RB
cord-304876-txaoz7oh	249	8	similar	similar	JJ
cord-304876-txaoz7oh	249	9	and	and	CC
cord-304876-txaoz7oh	249	10	have	have	VBP
cord-304876-txaoz7oh	249	11	sequence	sequence	NN
cord-304876-txaoz7oh	249	12	domains	domain	NNS
cord-304876-txaoz7oh	249	13	A	a	NN
cord-304876-txaoz7oh	249	14	-	-	HYPH
cord-304876-txaoz7oh	249	15	G	g	NN
cord-304876-txaoz7oh	249	16	indicating	indicate	VBG
cord-304876-txaoz7oh	249	17	this	this	DT
cord-304876-txaoz7oh	249	18	conservation	conservation	NN
cord-304876-txaoz7oh	249	19	.	.	.
cord-304876-txaoz7oh	250	1	89	89	CD
cord-304876-txaoz7oh	251	1	The	the	DT
cord-304876-txaoz7oh	251	2	460-residue	460-residue	CD
cord-304876-txaoz7oh	251	3	polymerase	polymerase	NN
cord-304876-txaoz7oh	251	4	domain	domain	NN
cord-304876-txaoz7oh	251	5	adopts	adopt	VBZ
cord-304876-txaoz7oh	251	6	a	a	DT
cord-304876-txaoz7oh	251	7	right	right	RB
cord-304876-txaoz7oh	251	8	-	-	HYPH
cord-304876-txaoz7oh	251	9	handed	handed	JJ
cord-304876-txaoz7oh	251	10	configuration	configuration	NN
cord-304876-txaoz7oh	251	11	with	with	IN
cord-304876-txaoz7oh	251	12	fingers	finger	NNS
cord-304876-txaoz7oh	251	13	,	,	,
cord-304876-txaoz7oh	251	14	palm	palm	NN
cord-304876-txaoz7oh	251	15	,	,	,
cord-304876-txaoz7oh	251	16	and	and	CC
cord-304876-txaoz7oh	251	17	thumb	thumb	NN
cord-304876-txaoz7oh	251	18	subdomains	subdomain	NNS
cord-304876-txaoz7oh	251	19	providing	provide	VBG
cord-304876-txaoz7oh	251	20	an	an	DT
cord-304876-txaoz7oh	251	21	optimal	optimal	JJ
cord-304876-txaoz7oh	251	22	arrangement	arrangement	NN
cord-304876-txaoz7oh	251	23	for	for	IN
cord-304876-txaoz7oh	251	24	substrate	substrate	NN
cord-304876-txaoz7oh	251	25	and	and	CC
cord-304876-txaoz7oh	251	26	metal	metal	NN
cord-304876-txaoz7oh	251	27	cation	cation	NN
cord-304876-txaoz7oh	251	28	access	access	NN
cord-304876-txaoz7oh	251	29	during	during	IN
cord-304876-txaoz7oh	251	30	the	the	DT
cord-304876-txaoz7oh	251	31	catalytic	catalytic	JJ
cord-304876-txaoz7oh	251	32	cycle	cycle	NN
cord-304876-txaoz7oh	251	33	.	.	.
cord-304876-txaoz7oh	252	1	The	the	DT
cord-304876-txaoz7oh	252	2	palm	palm	NN
cord-304876-txaoz7oh	252	3	,	,	,
cord-304876-txaoz7oh	252	4	fingers	finger	NNS
cord-304876-txaoz7oh	252	5	,	,	,
cord-304876-txaoz7oh	252	6	and	and	CC
cord-304876-txaoz7oh	252	7	thumb	thumb	NN
cord-304876-txaoz7oh	252	8	subdomains	subdomain	NNS
cord-304876-txaoz7oh	252	9	contain	contain	VBP
cord-304876-txaoz7oh	252	10	these	these	DT
cord-304876-txaoz7oh	252	11	sequence	sequence	NN
cord-304876-txaoz7oh	252	12	motifs	motif	NNS
cord-304876-txaoz7oh	252	13	(	(	-LRB-
cord-304876-txaoz7oh	252	14	motifs	motifs	VBP
cord-304876-txaoz7oh	252	15	A	a	NN
cord-304876-txaoz7oh	252	16	-	-	HYPH
cord-304876-txaoz7oh	252	17	E	e	NN
cord-304876-txaoz7oh	252	18	in	in	IN
cord-304876-txaoz7oh	252	19	the	the	DT
cord-304876-txaoz7oh	252	20	palm	palm	NN
cord-304876-txaoz7oh	252	21	subdomain	subdomain	NN
cord-304876-txaoz7oh	252	22	shown	show	VBN
cord-304876-txaoz7oh	252	23	in	in	IN
cord-304876-txaoz7oh	252	24	Figure	Figure	NNP
cord-304876-txaoz7oh	252	25	4	4	CD
cord-304876-txaoz7oh	252	26	)	)	-RRB-
cord-304876-txaoz7oh	252	27	.	.	.
cord-304876-txaoz7oh	253	1	90	90	CD
cord-304876-txaoz7oh	253	2	,	,	,
cord-304876-txaoz7oh	253	3	91	91	CD
cord-304876-txaoz7oh	254	1	These	these	DT
cord-304876-txaoz7oh	254	2	motifs	motif	NNS
cord-304876-txaoz7oh	254	3	have	have	VBP
cord-304876-txaoz7oh	254	4	specialized	specialize	VBN
cord-304876-txaoz7oh	254	5	roles	role	NNS
cord-304876-txaoz7oh	254	6	in	in	IN
cord-304876-txaoz7oh	254	7	catalysis	catalysis	NN
cord-304876-txaoz7oh	254	8	including	include	VBG
cord-304876-txaoz7oh	254	9	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	254	10	binding	binding	NN
cord-304876-txaoz7oh	254	11	and	and	CC
cord-304876-txaoz7oh	254	12	overall	overall	JJ
cord-304876-txaoz7oh	254	13	structural	structural	JJ
cord-304876-txaoz7oh	254	14	integrity	integrity	NN
cord-304876-txaoz7oh	254	15	of	of	IN
cord-304876-txaoz7oh	254	16	the	the	DT
cord-304876-txaoz7oh	254	17	active	active	JJ
cord-304876-txaoz7oh	254	18	site	site	NN
cord-304876-txaoz7oh	254	19	.	.	.
cord-304876-txaoz7oh	255	1	80	80	CD
cord-304876-txaoz7oh	256	1	The	the	DT
cord-304876-txaoz7oh	256	2	palm	palm	NN
cord-304876-txaoz7oh	256	3	contains	contain	VBZ
cord-304876-txaoz7oh	256	4	the	the	DT
cord-304876-txaoz7oh	256	5	active	active	JJ
cord-304876-txaoz7oh	256	6	site	site	NN
cord-304876-txaoz7oh	256	7	of	of	IN
cord-304876-txaoz7oh	256	8	all	all	PDT
cord-304876-txaoz7oh	256	9	the	the	DT
cord-304876-txaoz7oh	256	10	RdRps	RdRps	NNP
cord-304876-txaoz7oh	256	11	and	and	CC
cord-304876-txaoz7oh	256	12	its	-PRON-	PRP$
cord-304876-txaoz7oh	256	13	structure	structure	NN
cord-304876-txaoz7oh	256	14	consists	consist	VBZ
cord-304876-txaoz7oh	256	15	of	of	IN
cord-304876-txaoz7oh	256	16	an	an	DT
cord-304876-txaoz7oh	256	17	antiparallel	antiparallel	JJ
cord-304876-txaoz7oh	256	18	beta	beta	NN
cord-304876-txaoz7oh	256	19	-	-	HYPH
cord-304876-txaoz7oh	256	20	sheet	sheet	NN
cord-304876-txaoz7oh	256	21	surrounded	surround	VBN
cord-304876-txaoz7oh	256	22	by	by	IN
cord-304876-txaoz7oh	256	23	three	three	CD
cord-304876-txaoz7oh	256	24	alpha	alpha	NN
cord-304876-txaoz7oh	256	25	helices	helix	NNS
cord-304876-txaoz7oh	256	26	.	.	.
cord-304876-txaoz7oh	257	1	90	90	CD
cord-304876-txaoz7oh	257	2	Additional	additional	JJ
cord-304876-txaoz7oh	257	3	substructures	substructure	NNS
cord-304876-txaoz7oh	257	4	within	within	IN
cord-304876-txaoz7oh	257	5	the	the	DT
cord-304876-txaoz7oh	257	6	fingers	finger	NNS
cord-304876-txaoz7oh	257	7	domain	domain	NN
cord-304876-txaoz7oh	257	8	are	be	VBP
cord-304876-txaoz7oh	257	9	referred	refer	VBN
cord-304876-txaoz7oh	257	10	to	to	IN
cord-304876-txaoz7oh	257	11	as	as	IN
cord-304876-txaoz7oh	257	12	the	the	DT
cord-304876-txaoz7oh	257	13	index	index	NN
cord-304876-txaoz7oh	257	14	,	,	,
cord-304876-txaoz7oh	257	15	middle	middle	JJ
cord-304876-txaoz7oh	257	16	,	,	,
cord-304876-txaoz7oh	257	17	ring	ring	NN
cord-304876-txaoz7oh	257	18	,	,	,
cord-304876-txaoz7oh	257	19	and	and	CC
cord-304876-txaoz7oh	257	20	pinky	pinky	NNP
cord-304876-txaoz7oh	257	21	fingers	finger	NNS
cord-304876-txaoz7oh	257	22	.	.	.
cord-304876-txaoz7oh	258	1	82	82	CD
cord-304876-txaoz7oh	258	2	,	,	,
cord-304876-txaoz7oh	258	3	92	92	CD
cord-304876-txaoz7oh	259	1	All	all	DT
cord-304876-txaoz7oh	259	2	but	but	IN
cord-304876-txaoz7oh	259	3	the	the	DT
cord-304876-txaoz7oh	259	4	pinky	pinky	NNP
cord-304876-txaoz7oh	259	5	fingers	finger	NNS
cord-304876-txaoz7oh	259	6	build	build	VBP
cord-304876-txaoz7oh	259	7	an	an	DT
cord-304876-txaoz7oh	259	8	extended	extended	JJ
cord-304876-txaoz7oh	259	9	beta	beta	NN
cord-304876-txaoz7oh	259	10	-	-	HYPH
cord-304876-txaoz7oh	259	11	sheet	sheet	NN
cord-304876-txaoz7oh	259	12	that	that	WDT
cord-304876-txaoz7oh	259	13	seems	seem	VBZ
cord-304876-txaoz7oh	259	14	to	to	TO
cord-304876-txaoz7oh	259	15	be	be	VB
cord-304876-txaoz7oh	259	16	conserved	conserve	VBN
cord-304876-txaoz7oh	259	17	.	.	.
cord-304876-txaoz7oh	260	1	The	the	DT
cord-304876-txaoz7oh	260	2	index	index	NN
cord-304876-txaoz7oh	260	3	finger	finger	NN
cord-304876-txaoz7oh	260	4	within	within	IN
cord-304876-txaoz7oh	260	5	the	the	DT
cord-304876-txaoz7oh	260	6	fingers	finger	NNS
cord-304876-txaoz7oh	260	7	subdomain	subdomain	NN
cord-304876-txaoz7oh	260	8	makes	make	VBZ
cord-304876-txaoz7oh	260	9	an	an	DT
cord-304876-txaoz7oh	260	10	important	important	JJ
cord-304876-txaoz7oh	260	11	contact	contact	NN
cord-304876-txaoz7oh	260	12	with	with	IN
cord-304876-txaoz7oh	260	13	the	the	DT
cord-304876-txaoz7oh	260	14	thumb	thumb	NN
cord-304876-txaoz7oh	260	15	subdomain	subdomain	NN
cord-304876-txaoz7oh	260	16	and	and	CC
cord-304876-txaoz7oh	260	17	pushes	push	VBZ
cord-304876-txaoz7oh	260	18	the	the	DT
cord-304876-txaoz7oh	260	19	ring	ring	NN
cord-304876-txaoz7oh	260	20	finger	finger	NN
cord-304876-txaoz7oh	260	21	down	down	RP
cord-304876-txaoz7oh	260	22	to	to	TO
cord-304876-txaoz7oh	260	23	trap	trap	VB
cord-304876-txaoz7oh	260	24	it	-PRON-	PRP
cord-304876-txaoz7oh	260	25	.	.	.
cord-304876-txaoz7oh	261	1	This	this	DT
cord-304876-txaoz7oh	261	2	conformation	conformation	NN
cord-304876-txaoz7oh	261	3	results	result	VBZ
cord-304876-txaoz7oh	261	4	in	in	IN
cord-304876-txaoz7oh	261	5	the	the	DT
cord-304876-txaoz7oh	261	6	ring	ring	NN
cord-304876-txaoz7oh	261	7	finger	finger	NN
cord-304876-txaoz7oh	261	8	being	be	VBG
cord-304876-txaoz7oh	261	9	the	the	DT
cord-304876-txaoz7oh	261	10	roof	roof	NN
cord-304876-txaoz7oh	261	11	for	for	IN
cord-304876-txaoz7oh	261	12	NTP	NTP	NNP
cord-304876-txaoz7oh	261	13	entry	entry	NN
cord-304876-txaoz7oh	261	14	and	and	CC
cord-304876-txaoz7oh	261	15	making	make	VBG
cord-304876-txaoz7oh	261	16	important	important	JJ
cord-304876-txaoz7oh	261	17	interactions	interaction	NNS
cord-304876-txaoz7oh	261	18	with	with	IN
cord-304876-txaoz7oh	261	19	the	the	DT
cord-304876-txaoz7oh	261	20	triphosphate	triphosphate	NN
cord-304876-txaoz7oh	261	21	.	.	.
cord-304876-txaoz7oh	262	1	An	an	DT
cord-304876-txaoz7oh	262	2	additional	additional	JJ
cord-304876-txaoz7oh	262	3	structural	structural	JJ
cord-304876-txaoz7oh	262	4	feature	feature	NN
cord-304876-txaoz7oh	262	5	of	of	IN
cord-304876-txaoz7oh	262	6	motif	motif	NN
cord-304876-txaoz7oh	262	7	F	F	NNP
cord-304876-txaoz7oh	262	8	is	be	VBZ
cord-304876-txaoz7oh	262	9	a	a	DT
cord-304876-txaoz7oh	262	10	positively	positively	RB
cord-304876-txaoz7oh	262	11	charged	charge	VBN
cord-304876-txaoz7oh	262	12	tunnel	tunnel	NN
cord-304876-txaoz7oh	262	13	that	that	WDT
cord-304876-txaoz7oh	262	14	modulates	modulate	VBZ
cord-304876-txaoz7oh	262	15	the	the	DT
cord-304876-txaoz7oh	262	16	interactions	interaction	NNS
cord-304876-txaoz7oh	262	17	of	of	IN
cord-304876-txaoz7oh	262	18	NTP	NTP	NNP
cord-304876-txaoz7oh	262	19	.	.	.
cord-304876-txaoz7oh	263	1	93	93	CD
cord-304876-txaoz7oh	264	1	This	this	DT
cord-304876-txaoz7oh	264	2	tunnel	tunnel	NN
cord-304876-txaoz7oh	264	3	aides	aide	NNS
cord-304876-txaoz7oh	264	4	in	in	IN
cord-304876-txaoz7oh	264	5	the	the	DT
cord-304876-txaoz7oh	264	6	diffusion	diffusion	NN
cord-304876-txaoz7oh	264	7	of	of	IN
cord-304876-txaoz7oh	264	8	nucleotides	nucleotide	NNS
cord-304876-txaoz7oh	264	9	and	and	CC
cord-304876-txaoz7oh	264	10	is	be	VBZ
cord-304876-txaoz7oh	264	11	conserved	conserve	VBN
cord-304876-txaoz7oh	264	12	among	among	IN
cord-304876-txaoz7oh	264	13	this	this	DT
cord-304876-txaoz7oh	264	14	family	family	NN
cord-304876-txaoz7oh	264	15	of	of	IN
cord-304876-txaoz7oh	264	16	viruses	virus	NNS
cord-304876-txaoz7oh	264	17	.	.	.
cord-304876-txaoz7oh	265	1	Proteins	protein	NNS
cord-304876-txaoz7oh	265	2	and	and	CC
cord-304876-txaoz7oh	265	3	enzymes	enzyme	NNS
cord-304876-txaoz7oh	265	4	rarely	rarely	RB
cord-304876-txaoz7oh	265	5	exist	exist	VBP
cord-304876-txaoz7oh	265	6	in	in	IN
cord-304876-txaoz7oh	265	7	a	a	DT
cord-304876-txaoz7oh	265	8	monomeric	monomeric	JJ
cord-304876-txaoz7oh	265	9	state	state	NN
cord-304876-txaoz7oh	265	10	in	in	IN
cord-304876-txaoz7oh	265	11	nature	nature	NN
cord-304876-txaoz7oh	265	12	but	but	CC
cord-304876-txaoz7oh	265	13	are	be	VBP
cord-304876-txaoz7oh	265	14	energetically	energetically	RB
cord-304876-txaoz7oh	265	15	driven	drive	VBN
cord-304876-txaoz7oh	265	16	to	to	IN
cord-304876-txaoz7oh	265	17	higher	high	JJR
cord-304876-txaoz7oh	265	18	order	order	NN
cord-304876-txaoz7oh	265	19	,	,	,
cord-304876-txaoz7oh	265	20	oligomeric	oligomeric	JJ
cord-304876-txaoz7oh	265	21	states	state	NNS
cord-304876-txaoz7oh	265	22	through	through	IN
cord-304876-txaoz7oh	265	23	polar	polar	JJ
cord-304876-txaoz7oh	265	24	and	and	CC
cord-304876-txaoz7oh	265	25	hydrophobic	hydrophobic	JJ
cord-304876-txaoz7oh	265	26	interactions	interaction	NNS
cord-304876-txaoz7oh	265	27	and	and	CC
cord-304876-txaoz7oh	265	28	disulfide	disulfide	JJ
cord-304876-txaoz7oh	265	29	bond	bond	NN
cord-304876-txaoz7oh	265	30	formation	formation	NN
cord-304876-txaoz7oh	265	31	.	.	.
cord-304876-txaoz7oh	266	1	The	the	DT
cord-304876-txaoz7oh	266	2	development	development	NN
cord-304876-txaoz7oh	266	3	of	of	IN
cord-304876-txaoz7oh	266	4	increasingly	increasingly	RB
cord-304876-txaoz7oh	266	5	sophisticated	sophisticated	JJ
cord-304876-txaoz7oh	266	6	structural	structural	JJ
cord-304876-txaoz7oh	266	7	biology	biology	NN
cord-304876-txaoz7oh	266	8	techniques	technique	NNS
cord-304876-txaoz7oh	266	9	,	,	,
cord-304876-txaoz7oh	266	10	including	include	VBG
cord-304876-txaoz7oh	266	11	high	high	JJ
cord-304876-txaoz7oh	266	12	-	-	HYPH
cord-304876-txaoz7oh	266	13	resolution	resolution	NN
cord-304876-txaoz7oh	266	14	X	x	NN
cord-304876-txaoz7oh	266	15	-	-	NN
cord-304876-txaoz7oh	266	16	ray	ray	NN
cord-304876-txaoz7oh	266	17	crystal	crystal	NN
cord-304876-txaoz7oh	266	18	structures	structure	NNS
cord-304876-txaoz7oh	266	19	and	and	CC
cord-304876-txaoz7oh	266	20	cryo	cryo	NN
cord-304876-txaoz7oh	266	21	-	-	HYPH
cord-304876-txaoz7oh	266	22	EM	EM	NNP
cord-304876-txaoz7oh	266	23	,	,	,
cord-304876-txaoz7oh	266	24	has	have	VBZ
cord-304876-txaoz7oh	266	25	provided	provide	VBN
cord-304876-txaoz7oh	266	26	a	a	DT
cord-304876-txaoz7oh	266	27	snapshot	snapshot	NN
cord-304876-txaoz7oh	266	28	into	into	IN
cord-304876-txaoz7oh	266	29	how	how	WRB
cord-304876-txaoz7oh	266	30	polymerases	polymerase	NNS
cord-304876-txaoz7oh	266	31	may	may	MD
cord-304876-txaoz7oh	266	32	adopt	adopt	VB
cord-304876-txaoz7oh	266	33	such	such	JJ
cord-304876-txaoz7oh	266	34	oligomeric	oligomeric	JJ
cord-304876-txaoz7oh	266	35	states	state	NNS
cord-304876-txaoz7oh	266	36	.	.	.
cord-304876-txaoz7oh	267	1	The	the	DT
cord-304876-txaoz7oh	267	2	understanding	understanding	NN
cord-304876-txaoz7oh	267	3	and	and	CC
cord-304876-txaoz7oh	267	4	characterization	characterization	NN
cord-304876-txaoz7oh	267	5	of	of	IN
cord-304876-txaoz7oh	267	6	the	the	DT
cord-304876-txaoz7oh	267	7	oligomeric	oligomeric	JJ
cord-304876-txaoz7oh	267	8	states	state	NNS
cord-304876-txaoz7oh	267	9	place	place	VBP
cord-304876-txaoz7oh	267	10	these	these	DT
cord-304876-txaoz7oh	267	11	multifunctional	multifunctional	JJ
cord-304876-txaoz7oh	267	12	enzymes	enzyme	NNS
cord-304876-txaoz7oh	267	13	in	in	IN
cord-304876-txaoz7oh	267	14	a	a	DT
cord-304876-txaoz7oh	267	15	greater	great	JJR
cord-304876-txaoz7oh	267	16	biological	biological	JJ
cord-304876-txaoz7oh	267	17	context	context	NN
cord-304876-txaoz7oh	267	18	.	.	.
cord-304876-txaoz7oh	268	1	An	an	DT
cord-304876-txaoz7oh	268	2	example	example	NN
cord-304876-txaoz7oh	268	3	of	of	IN
cord-304876-txaoz7oh	268	4	such	such	JJ
cord-304876-txaoz7oh	268	5	oligomeric	oligomeric	JJ
cord-304876-txaoz7oh	268	6	states	state	NNS
cord-304876-txaoz7oh	268	7	and	and	CC
cord-304876-txaoz7oh	268	8	how	how	WRB
cord-304876-txaoz7oh	268	9	this	this	DT
cord-304876-txaoz7oh	268	10	impacts	impact	VBZ
cord-304876-txaoz7oh	268	11	the	the	DT
cord-304876-txaoz7oh	268	12	catalytic	catalytic	JJ
cord-304876-txaoz7oh	268	13	function	function	NN
cord-304876-txaoz7oh	268	14	is	be	VBZ
cord-304876-txaoz7oh	268	15	the	the	DT
cord-304876-txaoz7oh	268	16	polymerase	polymerase	NN
cord-304876-txaoz7oh	268	17	from	from	IN
cord-304876-txaoz7oh	268	18	PV	PV	NNP
cord-304876-txaoz7oh	268	19	.	.	.
cord-304876-txaoz7oh	269	1	PV	PV	NNP
cord-304876-txaoz7oh	269	2	RdRp	RdRp	NNP
cord-304876-txaoz7oh	269	3	is	be	VBZ
cord-304876-txaoz7oh	269	4	described	describe	VBN
cord-304876-txaoz7oh	269	5	as	as	IN
cord-304876-txaoz7oh	269	6	having	have	VBG
cord-304876-txaoz7oh	269	7	macromolecular	macromolecular	JJ
cord-304876-txaoz7oh	269	8	contacts	contact	NNS
cord-304876-txaoz7oh	269	9	at	at	IN
cord-304876-txaoz7oh	269	10	two	two	CD
cord-304876-txaoz7oh	269	11	polymerase	polymerase	NN
cord-304876-txaoz7oh	269	12	interfaces	interface	NNS
cord-304876-txaoz7oh	269	13	(	(	-LRB-
cord-304876-txaoz7oh	269	14	Interface	interface	NN
cord-304876-txaoz7oh	269	15	I	I	NNP
cord-304876-txaoz7oh	269	16	and	and	CC
cord-304876-txaoz7oh	269	17	Interface	Interface	NNP
cord-304876-txaoz7oh	269	18	II	II	NNP
cord-304876-txaoz7oh	269	19	)	)	-RRB-
cord-304876-txaoz7oh	269	20	.	.	.
cord-304876-txaoz7oh	270	1	94	94	CD
cord-304876-txaoz7oh	270	2	Interface	interface	NN
cord-304876-txaoz7oh	270	3	I	-PRON-	PRP
cord-304876-txaoz7oh	270	4	is	be	VBZ
cord-304876-txaoz7oh	270	5	defined	define	VBN
cord-304876-txaoz7oh	270	6	by	by	IN
cord-304876-txaoz7oh	270	7	the	the	DT
cord-304876-txaoz7oh	270	8	interaction	interaction	NN
cord-304876-txaoz7oh	270	9	of	of	IN
cord-304876-txaoz7oh	270	10	the	the	DT
cord-304876-txaoz7oh	270	11	thumb	thumb	NN
cord-304876-txaoz7oh	270	12	domain	domain	NN
cord-304876-txaoz7oh	270	13	from	from	IN
cord-304876-txaoz7oh	270	14	one	one	CD
cord-304876-txaoz7oh	270	15	polymerase	polymerase	NN
cord-304876-txaoz7oh	270	16	with	with	IN
cord-304876-txaoz7oh	270	17	the	the	DT
cord-304876-txaoz7oh	270	18	palm	palm	NN
cord-304876-txaoz7oh	270	19	of	of	IN
cord-304876-txaoz7oh	270	20	another	another	DT
cord-304876-txaoz7oh	270	21	polymerase	polymerase	NN
cord-304876-txaoz7oh	270	22	.	.	.
cord-304876-txaoz7oh	271	1	Interface	Interface	NNP
cord-304876-txaoz7oh	271	2	II	II	NNP
cord-304876-txaoz7oh	271	3	describes	describe	VBZ
cord-304876-txaoz7oh	271	4	interactions	interaction	NNS
cord-304876-txaoz7oh	271	5	of	of	IN
cord-304876-txaoz7oh	271	6	the	the	DT
cord-304876-txaoz7oh	271	7	N	n	CD
cord-304876-txaoz7oh	271	8	-	-	HYPH
cord-304876-txaoz7oh	271	9	terminus	terminus	NN
cord-304876-txaoz7oh	271	10	of	of	IN
cord-304876-txaoz7oh	271	11	one	one	CD
cord-304876-txaoz7oh	271	12	polymerase	polymerase	NN
cord-304876-txaoz7oh	271	13	with	with	IN
cord-304876-txaoz7oh	271	14	the	the	DT
cord-304876-txaoz7oh	271	15	thumb	thumb	NN
cord-304876-txaoz7oh	271	16	of	of	IN
cord-304876-txaoz7oh	271	17	a	a	DT
cord-304876-txaoz7oh	271	18	neighboring	neighboring	NN
cord-304876-txaoz7oh	271	19	polymerase	polymerase	NN
cord-304876-txaoz7oh	271	20	within	within	IN
cord-304876-txaoz7oh	271	21	the	the	DT
cord-304876-txaoz7oh	271	22	crystal	crystal	NN
cord-304876-txaoz7oh	271	23	lattice	lattice	NN
cord-304876-txaoz7oh	271	24	.	.	.
cord-304876-txaoz7oh	272	1	Additionally	additionally	RB
cord-304876-txaoz7oh	272	2	,	,	,
cord-304876-txaoz7oh	272	3	PV	PV	NNP
cord-304876-txaoz7oh	272	4	can	can	MD
cord-304876-txaoz7oh	272	5	form	form	VB
cord-304876-txaoz7oh	272	6	tube	tube	NN
cord-304876-txaoz7oh	272	7	-	-	HYPH
cord-304876-txaoz7oh	272	8	like	like	JJ
cord-304876-txaoz7oh	272	9	structures	structure	NNS
cord-304876-txaoz7oh	272	10	suggesting	suggest	VBG
cord-304876-txaoz7oh	272	11	it	-PRON-	PRP
cord-304876-txaoz7oh	272	12	is	be	VBZ
cord-304876-txaoz7oh	272	13	a	a	DT
cord-304876-txaoz7oh	272	14	highly	highly	RB
cord-304876-txaoz7oh	272	15	dynamic	dynamic	JJ
cord-304876-txaoz7oh	272	16	structure	structure	NN
cord-304876-txaoz7oh	272	17	able	able	JJ
cord-304876-txaoz7oh	272	18	to	to	TO
cord-304876-txaoz7oh	272	19	undergo	undergo	VB
cord-304876-txaoz7oh	272	20	and	and	CC
cord-304876-txaoz7oh	272	21	adopt	adopt	VB
cord-304876-txaoz7oh	272	22	multiple	multiple	JJ
cord-304876-txaoz7oh	272	23	conformational	conformational	JJ
cord-304876-txaoz7oh	272	24	arrangements	arrangement	NNS
cord-304876-txaoz7oh	272	25	.	.	.
cord-304876-txaoz7oh	273	1	95	95	CD
cord-304876-txaoz7oh	274	1	The	the	DT
cord-304876-txaoz7oh	274	2	oligomeric	oligomeric	JJ
cord-304876-txaoz7oh	274	3	state	state	NN
cord-304876-txaoz7oh	274	4	of	of	IN
cord-304876-txaoz7oh	274	5	PV	pv	NN
cord-304876-txaoz7oh	274	6	polymerase	polymerase	NN
cord-304876-txaoz7oh	274	7	is	be	VBZ
cord-304876-txaoz7oh	274	8	required	require	VBN
cord-304876-txaoz7oh	274	9	for	for	IN
cord-304876-txaoz7oh	274	10	membrane	membrane	NN
cord-304876-txaoz7oh	274	11	-	-	HYPH
cord-304876-txaoz7oh	274	12	associated	associate	VBN
cord-304876-txaoz7oh	274	13	RNA	RNA	NNP
cord-304876-txaoz7oh	274	14	replication	replication	NN
cord-304876-txaoz7oh	274	15	in	in	IN
cord-304876-txaoz7oh	274	16	infected	infected	JJ
cord-304876-txaoz7oh	274	17	cells	cell	NNS
cord-304876-txaoz7oh	274	18	,	,	,
cord-304876-txaoz7oh	274	19	as	as	IN
cord-304876-txaoz7oh	274	20	demonstrated	demonstrate	VBN
cord-304876-txaoz7oh	274	21	by	by	IN
cord-304876-txaoz7oh	274	22	mutating	mutate	VBG
cord-304876-txaoz7oh	274	23	residues	residue	NNS
cord-304876-txaoz7oh	274	24	involved	involve	VBN
cord-304876-txaoz7oh	274	25	in	in	IN
cord-304876-txaoz7oh	274	26	protein	protein	NN
cord-304876-txaoz7oh	274	27	-	-	HYPH
cord-304876-txaoz7oh	274	28	protein	protein	NN
cord-304876-txaoz7oh	274	29	interactions	interaction	NNS
cord-304876-txaoz7oh	274	30	.	.	.
cord-304876-txaoz7oh	275	1	96	96	CD
cord-304876-txaoz7oh	275	2	,	,	,
cord-304876-txaoz7oh	275	3	97	97	CD
cord-304876-txaoz7oh	276	1	The	the	DT
cord-304876-txaoz7oh	276	2	polymerase	polymerase	NN
cord-304876-txaoz7oh	276	3	of	of	IN
cord-304876-txaoz7oh	276	4	CoV	CoV	NNP
cord-304876-txaoz7oh	277	1	The	the	DT
cord-304876-txaoz7oh	277	2	CoV	cov	NN
cord-304876-txaoz7oh	277	3	are	be	VBP
cord-304876-txaoz7oh	277	4	part	part	NN
cord-304876-txaoz7oh	277	5	of	of	IN
cord-304876-txaoz7oh	277	6	the	the	DT
cord-304876-txaoz7oh	277	7	larger	large	JJR
cord-304876-txaoz7oh	277	8	nidovirus	nidovirus	NNP
cord-304876-txaoz7oh	277	9	family	family	NN
cord-304876-txaoz7oh	277	10	and	and	CC
cord-304876-txaoz7oh	277	11	have	have	VBP
cord-304876-txaoz7oh	277	12	exceptionally	exceptionally	RB
cord-304876-txaoz7oh	277	13	large	large	JJ
cord-304876-txaoz7oh	277	14	genomes	genome	NNS
cord-304876-txaoz7oh	277	15	of	of	IN
cord-304876-txaoz7oh	277	16	up	up	IN
cord-304876-txaoz7oh	277	17	to	to	TO
cord-304876-txaoz7oh	277	18	32	32	CD
cord-304876-txaoz7oh	277	19	kilobases	kilobase	NNS
cord-304876-txaoz7oh	277	20	in	in	IN
cord-304876-txaoz7oh	277	21	length	length	NN
cord-304876-txaoz7oh	277	22	.	.	.
cord-304876-txaoz7oh	278	1	98	98	CD
cord-304876-txaoz7oh	278	2	CoV	cov	NN
cord-304876-txaoz7oh	278	3	are	be	VBP
cord-304876-txaoz7oh	278	4	positive	positive	JJ
cord-304876-txaoz7oh	278	5	sense	sense	NN
cord-304876-txaoz7oh	279	1	RNA	RNA	NNP
cord-304876-txaoz7oh	279	2	viruses	virus	NNS
cord-304876-txaoz7oh	279	3	,	,	,
cord-304876-txaoz7oh	279	4	with	with	IN
cord-304876-txaoz7oh	279	5	a	a	DT
cord-304876-txaoz7oh	279	6	notable	notable	JJ
cord-304876-txaoz7oh	279	7	example	example	NN
cord-304876-txaoz7oh	279	8	being	be	VBG
cord-304876-txaoz7oh	279	9	SARS	SARS	NNP
cord-304876-txaoz7oh	279	10	as	as	IN
cord-304876-txaoz7oh	279	11	one	one	CD
cord-304876-txaoz7oh	279	12	of	of	IN
cord-304876-txaoz7oh	279	13	the	the	DT
cord-304876-txaoz7oh	279	14	most	most	RBS
cord-304876-txaoz7oh	279	15	pathogenic	pathogenic	JJ
cord-304876-txaoz7oh	279	16	member	member	NN
cord-304876-txaoz7oh	279	17	of	of	IN
cord-304876-txaoz7oh	279	18	this	this	DT
cord-304876-txaoz7oh	279	19	viral	viral	JJ
cord-304876-txaoz7oh	279	20	family	family	NN
cord-304876-txaoz7oh	279	21	.	.	.
cord-304876-txaoz7oh	280	1	99	99	CD
cord-304876-txaoz7oh	281	1	The	the	DT
cord-304876-txaoz7oh	281	2	CoV	cov	NN
cord-304876-txaoz7oh	281	3	genome	genome	NN
cord-304876-txaoz7oh	281	4	has	have	VBZ
cord-304876-txaoz7oh	281	5	a	a	DT
cord-304876-txaoz7oh	281	6	5	5	CD
cord-304876-txaoz7oh	281	7	0	0	CD
cord-304876-txaoz7oh	281	8	-cap	-cap	:
cord-304876-txaoz7oh	281	9	,	,	,
cord-304876-txaoz7oh	281	10	is	be	VBZ
cord-304876-txaoz7oh	281	11	polyadenylated	polyadenylate	VBN
cord-304876-txaoz7oh	281	12	on	on	IN
cord-304876-txaoz7oh	281	13	the	the	DT
cord-304876-txaoz7oh	281	14	3	3	CD
cord-304876-txaoz7oh	281	15	0	0	CD
cord-304876-txaoz7oh	281	16	end	end	NN
cord-304876-txaoz7oh	281	17	,	,	,
cord-304876-txaoz7oh	281	18	and	and	CC
cord-304876-txaoz7oh	281	19	generates	generate	VBZ
cord-304876-txaoz7oh	281	20	a	a	DT
cord-304876-txaoz7oh	281	21	total	total	NN
cord-304876-txaoz7oh	281	22	of	of	IN
cord-304876-txaoz7oh	281	23	16	16	CD
cord-304876-txaoz7oh	281	24	non	non	JJ
cord-304876-txaoz7oh	281	25	-	-	JJ
cord-304876-txaoz7oh	281	26	structural	structural	JJ
cord-304876-txaoz7oh	281	27	proteins	protein	NNS
cord-304876-txaoz7oh	281	28	(	(	-LRB-
cord-304876-txaoz7oh	281	29	nsp1	nsp1	NNS
cord-304876-txaoz7oh	281	30	to	to	IN
cord-304876-txaoz7oh	281	31	nsp16	nsp16	NNS
cord-304876-txaoz7oh	281	32	)	)	-RRB-
cord-304876-txaoz7oh	281	33	.	.	.
cord-304876-txaoz7oh	282	1	The	the	DT
cord-304876-txaoz7oh	282	2	5	5	CD
cord-304876-txaoz7oh	282	3	0	0	CD
cord-304876-txaoz7oh	282	4	two	two	CD
cord-304876-txaoz7oh	282	5	-	-	HYPH
cord-304876-txaoz7oh	282	6	thirds	third	NNS
cord-304876-txaoz7oh	282	7	of	of	IN
cord-304876-txaoz7oh	282	8	its	-PRON-	PRP$
cord-304876-txaoz7oh	282	9	genome	genome	NN
cord-304876-txaoz7oh	282	10	encodes	encode	VBZ
cord-304876-txaoz7oh	282	11	for	for	IN
cord-304876-txaoz7oh	282	12	non	non	JJ
cord-304876-txaoz7oh	282	13	-	-	JJ
cord-304876-txaoz7oh	282	14	structural	structural	JJ
cord-304876-txaoz7oh	282	15	proteins	protein	NNS
cord-304876-txaoz7oh	282	16	that	that	WDT
cord-304876-txaoz7oh	282	17	combine	combine	VBP
cord-304876-txaoz7oh	282	18	to	to	TO
cord-304876-txaoz7oh	282	19	form	form	VB
cord-304876-txaoz7oh	282	20	a	a	DT
cord-304876-txaoz7oh	282	21	replication	replication	NN
cord-304876-txaoz7oh	282	22	and	and	CC
cord-304876-txaoz7oh	282	23	transcription	transcription	NN
cord-304876-txaoz7oh	282	24	complex	complex	NN
cord-304876-txaoz7oh	282	25	that	that	WDT
cord-304876-txaoz7oh	282	26	completes	complete	VBZ
cord-304876-txaoz7oh	282	27	viral	viral	JJ
cord-304876-txaoz7oh	282	28	RNA	RNA	NNP
cord-304876-txaoz7oh	282	29	synthesis	synthesis	NN
cord-304876-txaoz7oh	282	30	.	.	.
cord-304876-txaoz7oh	283	1	100	100	CD
cord-304876-txaoz7oh	284	1	The	the	DT
cord-304876-txaoz7oh	284	2	Nsp12	Nsp12	NNP
cord-304876-txaoz7oh	284	3	protein	protein	NN
cord-304876-txaoz7oh	284	4	is	be	VBZ
cord-304876-txaoz7oh	284	5	the	the	DT
cord-304876-txaoz7oh	284	6	RdRp	RdRp	NNP
cord-304876-txaoz7oh	284	7	and	and	CC
cord-304876-txaoz7oh	284	8	is	be	VBZ
cord-304876-txaoz7oh	284	9	typically	typically	RB
cord-304876-txaoz7oh	284	10	composed	compose	VBN
cord-304876-txaoz7oh	284	11	of	of	IN
cord-304876-txaoz7oh	284	12	a	a	DT
cord-304876-txaoz7oh	284	13	N	n	CD
cord-304876-txaoz7oh	284	14	-	-	HYPH
cord-304876-txaoz7oh	284	15	terminal	terminal	NN
cord-304876-txaoz7oh	284	16	domain	domain	NN
cord-304876-txaoz7oh	284	17	composed	compose	VBN
cord-304876-txaoz7oh	284	18	of	of	IN
cord-304876-txaoz7oh	284	19	a	a	DT
cord-304876-txaoz7oh	284	20	nidovirusspecific	nidovirusspecific	NN
cord-304876-txaoz7oh	285	1	RdRp	RdRp	NNP
cord-304876-txaoz7oh	285	2	-	-	HYPH
cord-304876-txaoz7oh	285	3	associated	associate	VBN
cord-304876-txaoz7oh	285	4	nucleotidyltransferase	nucleotidyltransferase	NN
cord-304876-txaoz7oh	285	5	(	(	-LRB-
cord-304876-txaoz7oh	285	6	NiRAN	NiRAN	NNP
cord-304876-txaoz7oh	285	7	)	)	-RRB-
cord-304876-txaoz7oh	285	8	and	and	CC
cord-304876-txaoz7oh	285	9	a	a	DT
cord-304876-txaoz7oh	285	10	C	c	NN
cord-304876-txaoz7oh	285	11	-	-	HYPH
cord-304876-txaoz7oh	285	12	terminal	terminal	NN
cord-304876-txaoz7oh	285	13	containing	contain	VBG
cord-304876-txaoz7oh	285	14	the	the	DT
cord-304876-txaoz7oh	285	15	RdRp	RdRp	NNP
cord-304876-txaoz7oh	285	16	domain	domain	NN
cord-304876-txaoz7oh	285	17	,	,	,
cord-304876-txaoz7oh	285	18	which	which	WDT
cord-304876-txaoz7oh	285	19	contains	contain	VBZ
cord-304876-txaoz7oh	285	20	a	a	DT
cord-304876-txaoz7oh	285	21	set	set	NN
cord-304876-txaoz7oh	285	22	of	of	IN
cord-304876-txaoz7oh	285	23	six	six	CD
cord-304876-txaoz7oh	285	24	conserved	conserve	VBN
cord-304876-txaoz7oh	285	25	motifs	motif	NNS
cord-304876-txaoz7oh	285	26	(	(	-LRB-
cord-304876-txaoz7oh	285	27	motifs	motifs	VBP
cord-304876-txaoz7oh	285	28	A	a	NN
cord-304876-txaoz7oh	285	29	-	-	HYPH
cord-304876-txaoz7oh	285	30	F	F	NNP
cord-304876-txaoz7oh	285	31	)	)	-RRB-
cord-304876-txaoz7oh	285	32	responsible	responsible	JJ
cord-304876-txaoz7oh	285	33	for	for	IN
cord-304876-txaoz7oh	285	34	recognizing	recognize	VBG
cord-304876-txaoz7oh	285	35	substrates	substrate	NNS
cord-304876-txaoz7oh	285	36	and	and	CC
cord-304876-txaoz7oh	285	37	template	template	NN
cord-304876-txaoz7oh	285	38	.	.	.
cord-304876-txaoz7oh	286	1	98	98	CD
cord-304876-txaoz7oh	286	2	,	,	,
cord-304876-txaoz7oh	286	3	101	101	CD
cord-304876-txaoz7oh	287	1	The	the	DT
cord-304876-txaoz7oh	287	2	NiRAN	NiRAN	NNP
cord-304876-txaoz7oh	287	3	domain	domain	NN
cord-304876-txaoz7oh	287	4	has	have	VBZ
cord-304876-txaoz7oh	287	5	only	only	RB
cord-304876-txaoz7oh	287	6	been	be	VBN
cord-304876-txaoz7oh	287	7	identified	identify	VBN
cord-304876-txaoz7oh	287	8	in	in	IN
cord-304876-txaoz7oh	287	9	nidoviruses	nidoviruse	NNS
cord-304876-txaoz7oh	287	10	and	and	CC
cord-304876-txaoz7oh	287	11	is	be	VBZ
cord-304876-txaoz7oh	287	12	approximately	approximately	RB
cord-304876-txaoz7oh	287	13	300	300	CD
cord-304876-txaoz7oh	287	14	residues	residue	NNS
cord-304876-txaoz7oh	287	15	long	long	RB
cord-304876-txaoz7oh	287	16	in	in	IN
cord-304876-txaoz7oh	287	17	CoV.	CoV.	NNP
cord-304876-txaoz7oh	287	18	101	101	CD
cord-304876-txaoz7oh	288	1	In	in	IN
cord-304876-txaoz7oh	288	2	SARS	SARS	NNP
cord-304876-txaoz7oh	288	3	-	-	HYPH
cord-304876-txaoz7oh	288	4	CoV	CoV	NNP
cord-304876-txaoz7oh	288	5	,	,	,
cord-304876-txaoz7oh	288	6	a	a	DT
cord-304876-txaoz7oh	288	7	reverse	reverse	JJ
cord-304876-txaoz7oh	288	8	genetic	genetic	JJ
cord-304876-txaoz7oh	288	9	system	system	NN
cord-304876-txaoz7oh	288	10	identified	identify	VBD
cord-304876-txaoz7oh	288	11	this	this	DT
cord-304876-txaoz7oh	288	12	motif	motif	NN
cord-304876-txaoz7oh	288	13	as	as	IN
cord-304876-txaoz7oh	288	14	a	a	DT
cord-304876-txaoz7oh	288	15	requirement	requirement	NN
cord-304876-txaoz7oh	288	16	for	for	IN
cord-304876-txaoz7oh	288	17	replication	replication	NN
cord-304876-txaoz7oh	288	18	of	of	IN
cord-304876-txaoz7oh	288	19	its	-PRON-	PRP$
cord-304876-txaoz7oh	288	20	viral	viral	JJ
cord-304876-txaoz7oh	288	21	genome	genome	NN
cord-304876-txaoz7oh	288	22	.	.	.
cord-304876-txaoz7oh	289	1	While	while	IN
cord-304876-txaoz7oh	289	2	NiRAN	niran	JJ
cord-304876-txaoz7oh	289	3	activity	activity	NN
cord-304876-txaoz7oh	289	4	has	have	VBZ
cord-304876-txaoz7oh	289	5	not	not	RB
cord-304876-txaoz7oh	289	6	been	be	VBN
cord-304876-txaoz7oh	289	7	directly	directly	RB
cord-304876-txaoz7oh	289	8	observed	observe	VBN
cord-304876-txaoz7oh	289	9	outside	outside	RB
cord-304876-txaoz7oh	289	10	of	of	IN
cord-304876-txaoz7oh	289	11	a	a	DT
cord-304876-txaoz7oh	289	12	reverse	reverse	JJ
cord-304876-txaoz7oh	289	13	genetic	genetic	JJ
cord-304876-txaoz7oh	289	14	system	system	NN
cord-304876-txaoz7oh	289	15	for	for	IN
cord-304876-txaoz7oh	289	16	CoV	CoV	NNP
cord-304876-txaoz7oh	289	17	,	,	,
cord-304876-txaoz7oh	289	18	based	base	VBN
cord-304876-txaoz7oh	289	19	on	on	IN
cord-304876-txaoz7oh	289	20	the	the	DT
cord-304876-txaoz7oh	289	21	nucleotidylation	nucleotidylation	NN
cord-304876-txaoz7oh	289	22	activity	activity	NN
cord-304876-txaoz7oh	289	23	of	of	IN
cord-304876-txaoz7oh	289	24	EAV	EAV	NNP
cord-304876-txaoz7oh	289	25	nsp9	nsp9	NNP
cord-304876-txaoz7oh	289	26	,	,	,
cord-304876-txaoz7oh	289	27	the	the	DT
cord-304876-txaoz7oh	289	28	NiRAN	NiRAN	NNP
cord-304876-txaoz7oh	289	29	domain	domain	NN
cord-304876-txaoz7oh	289	30	is	be	VBZ
cord-304876-txaoz7oh	289	31	hypothesized	hypothesize	VBN
cord-304876-txaoz7oh	289	32	to	to	TO
cord-304876-txaoz7oh	289	33	play	play	VB
cord-304876-txaoz7oh	289	34	a	a	DT
cord-304876-txaoz7oh	289	35	role	role	NN
cord-304876-txaoz7oh	289	36	in	in	IN
cord-304876-txaoz7oh	289	37	protein	protein	NN
cord-304876-txaoz7oh	289	38	priming	priming	NN
cord-304876-txaoz7oh	289	39	,	,	,
cord-304876-txaoz7oh	289	40	capping	capping	NN
cord-304876-txaoz7oh	289	41	,	,	,
cord-304876-txaoz7oh	289	42	or	or	CC
cord-304876-txaoz7oh	289	43	as	as	IN
cord-304876-txaoz7oh	289	44	a	a	DT
cord-304876-txaoz7oh	289	45	potential	potential	JJ
cord-304876-txaoz7oh	289	46	universal	universal	JJ
cord-304876-txaoz7oh	289	47	ligation	ligation	NN
cord-304876-txaoz7oh	289	48	mechanism	mechanism	NN
cord-304876-txaoz7oh	289	49	.	.	.
cord-304876-txaoz7oh	290	1	98	98	CD
cord-304876-txaoz7oh	291	1	The	the	DT
cord-304876-txaoz7oh	291	2	active	active	JJ
cord-304876-txaoz7oh	291	3	site	site	NN
cord-304876-txaoz7oh	291	4	of	of	IN
cord-304876-txaoz7oh	291	5	the	the	DT
cord-304876-txaoz7oh	291	6	polymerase	polymerase	NN
cord-304876-txaoz7oh	291	7	is	be	VBZ
cord-304876-txaoz7oh	291	8	located	locate	VBN
cord-304876-txaoz7oh	291	9	within	within	IN
cord-304876-txaoz7oh	291	10	motif	motif	NN
cord-304876-txaoz7oh	291	11	C	c	NN
cord-304876-txaoz7oh	291	12	and	and	CC
cord-304876-txaoz7oh	291	13	is	be	VBZ
cord-304876-txaoz7oh	291	14	composed	compose	VBN
cord-304876-txaoz7oh	291	15	of	of	IN
cord-304876-txaoz7oh	291	16	conserved	conserve	VBN
cord-304876-txaoz7oh	291	17	(	(	-LRB-
cord-304876-txaoz7oh	291	18	within	within	IN
cord-304876-txaoz7oh	291	19	the	the	DT
cord-304876-txaoz7oh	291	20	Nidovirus	Nidovirus	NNP
cord-304876-txaoz7oh	291	21	family	family	NN
cord-304876-txaoz7oh	291	22	)	)	-RRB-
cord-304876-txaoz7oh	292	1	ser	ser	NNP
cord-304876-txaoz7oh	292	2	-	-	HYPH
cord-304876-txaoz7oh	292	3	asp	asp	NNP
cord-304876-txaoz7oh	292	4	-	-	HYPH
cord-304876-txaoz7oh	292	5	asp	asp	NN
cord-304876-txaoz7oh	292	6	residues	residue	NNS
cord-304876-txaoz7oh	292	7	.	.	.
cord-304876-txaoz7oh	293	1	Importantly	importantly	RB
cord-304876-txaoz7oh	293	2	,	,	,
cord-304876-txaoz7oh	293	3	conserved	conserved	JJ
cord-304876-txaoz7oh	293	4	aspartates	aspartate	NNS
cord-304876-txaoz7oh	293	5	found	find	VBN
cord-304876-txaoz7oh	293	6	in	in	IN
cord-304876-txaoz7oh	294	1	motif	motif	NNP
cord-304876-txaoz7oh	294	2	A	a	DT
cord-304876-txaoz7oh	294	3	of	of	IN
cord-304876-txaoz7oh	294	4	SARS	SARS	NNP
cord-304876-txaoz7oh	294	5	-	-	HYPH
cord-304876-txaoz7oh	294	6	CoV	CoV	NNP
cord-304876-txaoz7oh	294	7	,	,	,
cord-304876-txaoz7oh	294	8	which	which	WDT
cord-304876-txaoz7oh	294	9	combined	combine	VBD
cord-304876-txaoz7oh	294	10	with	with	IN
cord-304876-txaoz7oh	294	11	those	those	DT
cord-304876-txaoz7oh	294	12	found	find	VBN
cord-304876-txaoz7oh	294	13	in	in	IN
cord-304876-txaoz7oh	294	14	motif	motif	NN
cord-304876-txaoz7oh	294	15	C	C	NNP
cord-304876-txaoz7oh	294	16	,	,	,
cord-304876-txaoz7oh	294	17	contribute	contribute	VB
cord-304876-txaoz7oh	294	18	to	to	IN
cord-304876-txaoz7oh	294	19	the	the	DT
cord-304876-txaoz7oh	294	20	polymerase	polymerase	NN
cord-304876-txaoz7oh	294	21	and	and	CC
cord-304876-txaoz7oh	294	22	RNA	RNA	NNP
cord-304876-txaoz7oh	294	23	synthesis	synthesis	NN
cord-304876-txaoz7oh	294	24	activities	activity	NNS
cord-304876-txaoz7oh	294	25	.	.	.
cord-304876-txaoz7oh	295	1	This	this	DT
cord-304876-txaoz7oh	295	2	is	be	VBZ
cord-304876-txaoz7oh	295	3	different	different	JJ
cord-304876-txaoz7oh	295	4	from	from	IN
cord-304876-txaoz7oh	295	5	other	other	JJ
cord-304876-txaoz7oh	295	6	positive	positive	JJ
cord-304876-txaoz7oh	295	7	strand	strand	NN
cord-304876-txaoz7oh	295	8	RNA	RNA	NNP
cord-304876-txaoz7oh	295	9	viruses	virus	NNS
cord-304876-txaoz7oh	295	10	which	which	WDT
cord-304876-txaoz7oh	295	11	contain	contain	VBP
cord-304876-txaoz7oh	295	12	a	a	DT
cord-304876-txaoz7oh	295	13	GDD	GDD	NNP
cord-304876-txaoz7oh	295	14	active	active	JJ
cord-304876-txaoz7oh	295	15	site	site	NN
cord-304876-txaoz7oh	295	16	.	.	.
cord-304876-txaoz7oh	296	1	Motif	motif	VB
cord-304876-txaoz7oh	296	2	A	a	NN
cord-304876-txaoz7oh	296	3	along	along	IN
cord-304876-txaoz7oh	296	4	with	with	IN
cord-304876-txaoz7oh	296	5	motif	motif	NN
cord-304876-txaoz7oh	296	6	C	c	NN
cord-304876-txaoz7oh	296	7	aid	aid	NN
cord-304876-txaoz7oh	296	8	in	in	IN
cord-304876-txaoz7oh	296	9	coordinating	coordinate	VBG
cord-304876-txaoz7oh	296	10	the	the	DT
cord-304876-txaoz7oh	296	11	metal	metal	NN
cord-304876-txaoz7oh	296	12	ions	ion	NNS
cord-304876-txaoz7oh	296	13	necessary	necessary	JJ
cord-304876-txaoz7oh	296	14	for	for	IN
cord-304876-txaoz7oh	296	15	catalysis	catalysis	NN
cord-304876-txaoz7oh	296	16	.	.	.
cord-304876-txaoz7oh	297	1	The	the	DT
cord-304876-txaoz7oh	297	2	SARS	SARS	NNP
cord-304876-txaoz7oh	297	3	-	-	HYPH
cord-304876-txaoz7oh	297	4	CoV	CoV	NNP
cord-304876-txaoz7oh	297	5	harbors	harbor	VBZ
cord-304876-txaoz7oh	297	6	a	a	DT
cord-304876-txaoz7oh	297	7	signature	signature	NN
cord-304876-txaoz7oh	297	8	sequence	sequence	NN
cord-304876-txaoz7oh	297	9	in	in	IN
cord-304876-txaoz7oh	297	10	motif	motif	NN
cord-304876-txaoz7oh	297	11	G	g	NN
cord-304876-txaoz7oh	297	12	necessary	necessary	JJ
cord-304876-txaoz7oh	297	13	for	for	IN
cord-304876-txaoz7oh	297	14	primer	primer	NN
cord-304876-txaoz7oh	297	15	-	-	HYPH
cord-304876-txaoz7oh	297	16	dependent	dependent	JJ
cord-304876-txaoz7oh	297	17	RNA	RNA	NNP
cord-304876-txaoz7oh	297	18	synthesis	synthesis	NN
cord-304876-txaoz7oh	297	19	.	.	.
cord-304876-txaoz7oh	298	1	102	102	CD
cord-304876-txaoz7oh	298	2	,	,	,
cord-304876-txaoz7oh	298	3	103	103	CD
cord-304876-txaoz7oh	298	4	Due	due	IN
cord-304876-txaoz7oh	298	5	to	to	IN
cord-304876-txaoz7oh	298	6	difficulties	difficulty	NNS
cord-304876-txaoz7oh	298	7	in	in	IN
cord-304876-txaoz7oh	298	8	obtaining	obtain	VBG
cord-304876-txaoz7oh	298	9	large	large	JJ
cord-304876-txaoz7oh	298	10	enough	enough	JJ
cord-304876-txaoz7oh	298	11	amounts	amount	NNS
cord-304876-txaoz7oh	298	12	of	of	IN
cord-304876-txaoz7oh	298	13	highly	highly	RB
cord-304876-txaoz7oh	298	14	pure	pure	JJ
cord-304876-txaoz7oh	298	15	protein	protein	NN
cord-304876-txaoz7oh	298	16	,	,	,
cord-304876-txaoz7oh	298	17	the	the	DT
cord-304876-txaoz7oh	298	18	structures	structure	NNS
cord-304876-txaoz7oh	298	19	of	of	IN
cord-304876-txaoz7oh	298	20	CoV	CoV	NNP
cord-304876-txaoz7oh	298	21	nsp12	nsp12	CD
cord-304876-txaoz7oh	298	22	have	have	VBP
cord-304876-txaoz7oh	298	23	not	not	RB
cord-304876-txaoz7oh	298	24	been	be	VBN
cord-304876-txaoz7oh	298	25	solved	solve	VBN
cord-304876-txaoz7oh	298	26	either	either	CC
cord-304876-txaoz7oh	298	27	by	by	IN
cord-304876-txaoz7oh	298	28	X	x	NN
cord-304876-txaoz7oh	298	29	-	-	NN
cord-304876-txaoz7oh	298	30	ray	ray	JJ
cord-304876-txaoz7oh	298	31	crystallography	crystallography	NN
cord-304876-txaoz7oh	298	32	or	or	CC
cord-304876-txaoz7oh	298	33	cryo	cryo	NN
cord-304876-txaoz7oh	298	34	-	-	HYPH
cord-304876-txaoz7oh	298	35	EM	em	NN
cord-304876-txaoz7oh	298	36	.	.	.
cord-304876-txaoz7oh	299	1	Therefore	therefore	RB
cord-304876-txaoz7oh	299	2	,	,	,
cord-304876-txaoz7oh	299	3	the	the	DT
cord-304876-txaoz7oh	299	4	structural	structural	JJ
cord-304876-txaoz7oh	299	5	information	information	NN
cord-304876-txaoz7oh	299	6	currently	currently	RB
cord-304876-txaoz7oh	299	7	available	available	JJ
cord-304876-txaoz7oh	299	8	is	be	VBZ
cord-304876-txaoz7oh	299	9	based	base	VBN
cord-304876-txaoz7oh	299	10	solely	solely	RB
cord-304876-txaoz7oh	299	11	on	on	IN
cord-304876-txaoz7oh	299	12	structural	structural	JJ
cord-304876-txaoz7oh	299	13	models	model	NNS
cord-304876-txaoz7oh	299	14	obtained	obtain	VBN
cord-304876-txaoz7oh	299	15	via	via	IN
cord-304876-txaoz7oh	299	16	sequence	sequence	NN
cord-304876-txaoz7oh	299	17	alignment	alignment	NN
cord-304876-txaoz7oh	299	18	and	and	CC
cord-304876-txaoz7oh	299	19	homology	homology	NN
cord-304876-txaoz7oh	299	20	modeling	modeling	NN
cord-304876-txaoz7oh	299	21	techniques	technique	NNS
cord-304876-txaoz7oh	299	22	.	.	.
cord-304876-txaoz7oh	300	1	These	these	DT
cord-304876-txaoz7oh	300	2	models	model	NNS
cord-304876-txaoz7oh	300	3	indicate	indicate	VBP
cord-304876-txaoz7oh	300	4	a	a	DT
cord-304876-txaoz7oh	300	5	right	right	RB
cord-304876-txaoz7oh	300	6	-	-	HYPH
cord-304876-txaoz7oh	300	7	handed	handed	JJ
cord-304876-txaoz7oh	300	8	fold	fold	NN
cord-304876-txaoz7oh	300	9	composed	compose	VBN
cord-304876-txaoz7oh	300	10	of	of	IN
cord-304876-txaoz7oh	300	11	fingers	finger	NNS
cord-304876-txaoz7oh	300	12	,	,	,
cord-304876-txaoz7oh	300	13	palm	palm	NN
cord-304876-txaoz7oh	300	14	,	,	,
cord-304876-txaoz7oh	300	15	and	and	CC
cord-304876-txaoz7oh	300	16	thumb	thumb	NN
cord-304876-txaoz7oh	300	17	subdomains	subdomain	NNS
cord-304876-txaoz7oh	300	18	with	with	IN
cord-304876-txaoz7oh	300	19	clearly	clearly	RB
cord-304876-txaoz7oh	300	20	defined	define	VBN
cord-304876-txaoz7oh	300	21	entry	entry	NN
cord-304876-txaoz7oh	300	22	and	and	CC
cord-304876-txaoz7oh	300	23	exit	exit	NN
cord-304876-txaoz7oh	300	24	channels	channel	NNS
cord-304876-txaoz7oh	300	25	,	,	,
cord-304876-txaoz7oh	300	26	consistent	consistent	JJ
cord-304876-txaoz7oh	300	27	with	with	IN
cord-304876-txaoz7oh	300	28	RdRp	RdRp	NNP
cord-304876-txaoz7oh	300	29	domains	domain	NNS
cord-304876-txaoz7oh	300	30	for	for	IN
cord-304876-txaoz7oh	300	31	other	other	JJ
cord-304876-txaoz7oh	300	32	structurally	structurally	RB
cord-304876-txaoz7oh	300	33	characterized	characterize	VBN
cord-304876-txaoz7oh	300	34	positive	positive	JJ
cord-304876-txaoz7oh	300	35	sense	sense	NN
cord-304876-txaoz7oh	300	36	RNA	rna	NN
cord-304876-txaoz7oh	300	37	polymerases	polymerase	NNS
cord-304876-txaoz7oh	300	38	(	(	-LRB-
cord-304876-txaoz7oh	300	39	for	for	IN
cord-304876-txaoz7oh	300	40	example	example	NN
cord-304876-txaoz7oh	300	41	,	,	,
cord-304876-txaoz7oh	300	42	foot	foot	NN
cord-304876-txaoz7oh	300	43	-	-	HYPH
cord-304876-txaoz7oh	300	44	and	and	CC
cord-304876-txaoz7oh	300	45	-	-	HYPH
cord-304876-txaoz7oh	300	46	mouth	mouth	NN
cord-304876-txaoz7oh	300	47	disease	disease	NN
cord-304876-txaoz7oh	300	48	virus	virus	NN
cord-304876-txaoz7oh	300	49	)	)	-RRB-
cord-304876-txaoz7oh	300	50	but	but	CC
cord-304876-txaoz7oh	300	51	clearly	clearly	RB
cord-304876-txaoz7oh	300	52	distinct	distinct	JJ
cord-304876-txaoz7oh	300	53	from	from	IN
cord-304876-txaoz7oh	300	54	the	the	DT
cord-304876-txaoz7oh	300	55	known	know	VBN
cord-304876-txaoz7oh	300	56	molecular	molecular	JJ
cord-304876-txaoz7oh	300	57	topology	topology	NN
cord-304876-txaoz7oh	300	58	of	of	IN
cord-304876-txaoz7oh	300	59	negative	negative	JJ
cord-304876-txaoz7oh	300	60	-	-	HYPH
cord-304876-txaoz7oh	300	61	stranded	strand	VBN
cord-304876-txaoz7oh	300	62	RdRps	RdRps	NNP
cord-304876-txaoz7oh	300	63	.	.	.
cord-304876-txaoz7oh	301	1	No	no	DT
cord-304876-txaoz7oh	301	2	structural	structural	JJ
cord-304876-txaoz7oh	301	3	models	model	NNS
cord-304876-txaoz7oh	301	4	predict	predict	VBP
cord-304876-txaoz7oh	301	5	the	the	DT
cord-304876-txaoz7oh	301	6	presence	presence	NN
cord-304876-txaoz7oh	301	7	of	of	IN
cord-304876-txaoz7oh	301	8	a	a	DT
cord-304876-txaoz7oh	301	9	priming	priming	NN
cord-304876-txaoz7oh	301	10	loop	loop	NN
cord-304876-txaoz7oh	301	11	.	.	.
cord-304876-txaoz7oh	302	1	These	these	DT
cord-304876-txaoz7oh	302	2	data	datum	NNS
cord-304876-txaoz7oh	302	3	combined	combine	VBN
cord-304876-txaoz7oh	302	4	with	with	IN
cord-304876-txaoz7oh	302	5	biochemical	biochemical	JJ
cord-304876-txaoz7oh	302	6	data	datum	NNS
cord-304876-txaoz7oh	302	7	indicating	indicate	VBG
cord-304876-txaoz7oh	302	8	no	no	DT
cord-304876-txaoz7oh	302	9	de	de	FW
cord-304876-txaoz7oh	302	10	novo	novo	NN
cord-304876-txaoz7oh	302	11	initiation	initiation	NN
cord-304876-txaoz7oh	302	12	of	of	IN
cord-304876-txaoz7oh	302	13	RNA	RNA	NNP
cord-304876-txaoz7oh	302	14	synthesis	synthesis	NN
cord-304876-txaoz7oh	302	15	may	may	MD
cord-304876-txaoz7oh	302	16	account	account	VB
cord-304876-txaoz7oh	302	17	for	for	IN
cord-304876-txaoz7oh	302	18	the	the	DT
cord-304876-txaoz7oh	302	19	functionality	functionality	NN
cord-304876-txaoz7oh	302	20	of	of	IN
cord-304876-txaoz7oh	302	21	motif	motif	NN
cord-304876-txaoz7oh	302	22	G.	G.	NNP
cord-304876-txaoz7oh	302	23	A	a	DT
cord-304876-txaoz7oh	302	24	complete	complete	JJ
cord-304876-txaoz7oh	302	25	characterization	characterization	NN
cord-304876-txaoz7oh	302	26	of	of	IN
cord-304876-txaoz7oh	302	27	the	the	DT
cord-304876-txaoz7oh	302	28	in	in	FW
cord-304876-txaoz7oh	302	29	vitro	vitro	FW
cord-304876-txaoz7oh	302	30	nsp12	nsp12	CD
cord-304876-txaoz7oh	302	31	RdRp	RdRp	NNP
cord-304876-txaoz7oh	302	32	activity	activity	NN
cord-304876-txaoz7oh	302	33	has	have	VBZ
cord-304876-txaoz7oh	302	34	demonstrated	demonstrate	VBN
cord-304876-txaoz7oh	302	35	overall	overall	JJ
cord-304876-txaoz7oh	302	36	weak	weak	JJ
cord-304876-txaoz7oh	302	37	activity	activity	NN
cord-304876-txaoz7oh	302	38	.	.	.
cord-304876-txaoz7oh	303	1	Initial	initial	JJ
cord-304876-txaoz7oh	303	2	evidence	evidence	NN
cord-304876-txaoz7oh	303	3	suggested	suggest	VBD
cord-304876-txaoz7oh	303	4	that	that	IN
cord-304876-txaoz7oh	303	5	a	a	DT
cord-304876-txaoz7oh	303	6	previously	previously	RB
cord-304876-txaoz7oh	303	7	uncharacterized	uncharacterized	JJ
cord-304876-txaoz7oh	303	8	N	n	CD
cord-304876-txaoz7oh	303	9	-	-	HYPH
cord-304876-txaoz7oh	303	10	terminal	terminal	NN
cord-304876-txaoz7oh	303	11	domain	domain	NN
cord-304876-txaoz7oh	303	12	may	may	MD
cord-304876-txaoz7oh	303	13	have	have	VB
cord-304876-txaoz7oh	303	14	been	be	VBN
cord-304876-txaoz7oh	303	15	required	require	VBN
cord-304876-txaoz7oh	303	16	for	for	IN
cord-304876-txaoz7oh	303	17	polymerase	polymerase	NN
cord-304876-txaoz7oh	303	18	activity	activity	NN
cord-304876-txaoz7oh	303	19	.	.	.
cord-304876-txaoz7oh	304	1	104	104	CD
cord-304876-txaoz7oh	305	1	However	however	RB
cord-304876-txaoz7oh	305	2	,	,	,
cord-304876-txaoz7oh	305	3	the	the	DT
cord-304876-txaoz7oh	305	4	addition	addition	NN
cord-304876-txaoz7oh	305	5	of	of	IN
cord-304876-txaoz7oh	305	6	this	this	DT
cord-304876-txaoz7oh	305	7	domain	domain	NN
cord-304876-txaoz7oh	305	8	using	use	VBG
cord-304876-txaoz7oh	305	9	a	a	DT
cord-304876-txaoz7oh	305	10	C	c	NN
cord-304876-txaoz7oh	305	11	-	-	HYPH
cord-304876-txaoz7oh	305	12	terminally	terminally	RB
cord-304876-txaoz7oh	305	13	tagged	tag	VBN
cord-304876-txaoz7oh	305	14	protein	protein	NN
cord-304876-txaoz7oh	305	15	still	still	RB
cord-304876-txaoz7oh	305	16	yielded	yield	VBD
cord-304876-txaoz7oh	305	17	protein	protein	NN
cord-304876-txaoz7oh	305	18	with	with	IN
cord-304876-txaoz7oh	305	19	poor	poor	JJ
cord-304876-txaoz7oh	305	20	activity	activity	NN
cord-304876-txaoz7oh	305	21	and	and	CC
cord-304876-txaoz7oh	305	22	processivity	processivity	NN
cord-304876-txaoz7oh	305	23	.	.	.
cord-304876-txaoz7oh	306	1	Based	base	VBN
cord-304876-txaoz7oh	306	2	on	on	IN
cord-304876-txaoz7oh	306	3	these	these	DT
cord-304876-txaoz7oh	306	4	results	result	NNS
cord-304876-txaoz7oh	306	5	and	and	CC
cord-304876-txaoz7oh	306	6	to	to	TO
cord-304876-txaoz7oh	306	7	increase	increase	VB
cord-304876-txaoz7oh	306	8	the	the	DT
cord-304876-txaoz7oh	306	9	in	in	FW
cord-304876-txaoz7oh	306	10	vitro	vitro	FW
cord-304876-txaoz7oh	306	11	activity	activity	NN
cord-304876-txaoz7oh	306	12	of	of	IN
cord-304876-txaoz7oh	306	13	the	the	DT
cord-304876-txaoz7oh	306	14	nsp12	nsp12	CD
cord-304876-txaoz7oh	306	15	,	,	,
cord-304876-txaoz7oh	306	16	two	two	CD
cord-304876-txaoz7oh	306	17	other	other	JJ
cord-304876-txaoz7oh	306	18	non	non	JJ
cord-304876-txaoz7oh	306	19	-	-	JJ
cord-304876-txaoz7oh	306	20	structural	structural	JJ
cord-304876-txaoz7oh	306	21	proteins	protein	NNS
cord-304876-txaoz7oh	306	22	,	,	,
cord-304876-txaoz7oh	306	23	nsp7	nsp7	NN
cord-304876-txaoz7oh	306	24	and	and	CC
cord-304876-txaoz7oh	306	25	nsp8	nsp8	NN
cord-304876-txaoz7oh	306	26	,	,	,
cord-304876-txaoz7oh	306	27	were	be	VBD
cord-304876-txaoz7oh	306	28	added	add	VBN
cord-304876-txaoz7oh	306	29	to	to	IN
cord-304876-txaoz7oh	306	30	the	the	DT
cord-304876-txaoz7oh	306	31	nsp12	nsp12	CD
cord-304876-txaoz7oh	306	32	protein	protein	NN
cord-304876-txaoz7oh	306	33	in	in	IN
cord-304876-txaoz7oh	306	34	a	a	DT
cord-304876-txaoz7oh	306	35	primer	primer	NN
cord-304876-txaoz7oh	306	36	extension	extension	NN
cord-304876-txaoz7oh	306	37	mode	mode	NN
cord-304876-txaoz7oh	306	38	.	.	.
cord-304876-txaoz7oh	307	1	100	100	CD
cord-304876-txaoz7oh	308	1	The	the	DT
cord-304876-txaoz7oh	308	2	addition	addition	NN
cord-304876-txaoz7oh	308	3	of	of	IN
cord-304876-txaoz7oh	308	4	nsp7	nsp7	NN
cord-304876-txaoz7oh	308	5	and	and	CC
cord-304876-txaoz7oh	308	6	nsp8	nsp8	NN
cord-304876-txaoz7oh	308	7	to	to	TO
cord-304876-txaoz7oh	308	8	nsp12	nsp12	NNS
cord-304876-txaoz7oh	308	9	appear	appear	VB
cord-304876-txaoz7oh	308	10	to	to	TO
cord-304876-txaoz7oh	308	11	activate	activate	VB
cord-304876-txaoz7oh	308	12	and	and	CC
cord-304876-txaoz7oh	308	13	increase	increase	VB
cord-304876-txaoz7oh	308	14	the	the	DT
cord-304876-txaoz7oh	308	15	processivity	processivity	NN
cord-304876-txaoz7oh	308	16	of	of	IN
cord-304876-txaoz7oh	308	17	the	the	DT
cord-304876-txaoz7oh	308	18	polymerase	polymerase	NN
cord-304876-txaoz7oh	308	19	allowing	allow	VBG
cord-304876-txaoz7oh	308	20	it	-PRON-	PRP
cord-304876-txaoz7oh	308	21	to	to	TO
cord-304876-txaoz7oh	308	22	produce	produce	VB
cord-304876-txaoz7oh	308	23	an	an	DT
cord-304876-txaoz7oh	308	24	RNA	RNA	NNP
cord-304876-txaoz7oh	308	25	synthesis	synthesis	NN
cord-304876-txaoz7oh	308	26	product	product	NN
cord-304876-txaoz7oh	308	27	of	of	IN
cord-304876-txaoz7oh	308	28	340	340	CD
cord-304876-txaoz7oh	308	29	nucleotides	nucleotide	NNS
cord-304876-txaoz7oh	308	30	in	in	IN
cord-304876-txaoz7oh	308	31	the	the	DT
cord-304876-txaoz7oh	308	32	presence	presence	NN
cord-304876-txaoz7oh	308	33	of	of	IN
cord-304876-txaoz7oh	308	34	Mg	Mg	NNP
cord-304876-txaoz7oh	308	35	2þ	2þ	NNS
cord-304876-txaoz7oh	308	36	.	.	.
cord-304876-txaoz7oh	309	1	Linking	link	VBG
cord-304876-txaoz7oh	309	2	the	the	DT
cord-304876-txaoz7oh	309	3	nsp7	nsp7	JJ
cord-304876-txaoz7oh	309	4	and	and	CC
cord-304876-txaoz7oh	309	5	nsp8	nsp8	JJ
cord-304876-txaoz7oh	309	6	subunits	subunit	NNS
cord-304876-txaoz7oh	309	7	together	together	RB
cord-304876-txaoz7oh	309	8	also	also	RB
cord-304876-txaoz7oh	309	9	increased	increase	VBD
cord-304876-txaoz7oh	309	10	the	the	DT
cord-304876-txaoz7oh	309	11	polymerase	polymerase	NN
cord-304876-txaoz7oh	309	12	reaction	reaction	NN
cord-304876-txaoz7oh	309	13	efficiency	efficiency	NN
cord-304876-txaoz7oh	309	14	suggesting	suggest	VBG
cord-304876-txaoz7oh	309	15	that	that	IN
cord-304876-txaoz7oh	309	16	nsp7-nsp8	nsp7-nsp8	DT
cord-304876-txaoz7oh	309	17	complex	complex	JJ
cord-304876-txaoz7oh	309	18	formation	formation	NN
cord-304876-txaoz7oh	309	19	may	may	MD
cord-304876-txaoz7oh	309	20	influence	influence	VB
cord-304876-txaoz7oh	309	21	the	the	DT
cord-304876-txaoz7oh	309	22	reaction	reaction	NN
cord-304876-txaoz7oh	309	23	rate	rate	NN
cord-304876-txaoz7oh	309	24	.	.	.
cord-304876-txaoz7oh	310	1	Importantly	importantly	RB
cord-304876-txaoz7oh	310	2	,	,	,
cord-304876-txaoz7oh	310	3	nsp14	nsp14	ADD
cord-304876-txaoz7oh	310	4	can	can	MD
cord-304876-txaoz7oh	310	5	interact	interact	VB
cord-304876-txaoz7oh	310	6	with	with	IN
cord-304876-txaoz7oh	310	7	an	an	DT
cord-304876-txaoz7oh	310	8	nsp7-nsp8-nsp12	nsp7-nsp8-nsp12	UH
cord-304876-txaoz7oh	310	9	complex	complex	NN
cord-304876-txaoz7oh	310	10	without	without	IN
cord-304876-txaoz7oh	310	11	influencing	influence	VBG
cord-304876-txaoz7oh	310	12	RNA	RNA	NNP
cord-304876-txaoz7oh	310	13	synthesis	synthesis	NN
cord-304876-txaoz7oh	310	14	activities	activity	NNS
cord-304876-txaoz7oh	310	15	.	.	.
cord-304876-txaoz7oh	311	1	100	100	CD
cord-304876-txaoz7oh	311	2	Nsp14	Nsp14	NNP
cord-304876-txaoz7oh	311	3	contains	contain	VBZ
cord-304876-txaoz7oh	311	4	an	an	DT
cord-304876-txaoz7oh	311	5	exoribonuclease	exoribonuclease	NN
cord-304876-txaoz7oh	311	6	domain	domain	NN
cord-304876-txaoz7oh	311	7	that	that	WDT
cord-304876-txaoz7oh	311	8	has	have	VBZ
cord-304876-txaoz7oh	311	9	been	be	VBN
cord-304876-txaoz7oh	311	10	shown	show	VBN
cord-304876-txaoz7oh	311	11	to	to	TO
cord-304876-txaoz7oh	311	12	decrease	decrease	VB
cord-304876-txaoz7oh	311	13	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	311	14	mismatch	mismatch	NN
cord-304876-txaoz7oh	311	15	,	,	,
cord-304876-txaoz7oh	311	16	in	in	IN
cord-304876-txaoz7oh	311	17	many	many	JJ
cord-304876-txaoz7oh	311	18	ways	way	NNS
cord-304876-txaoz7oh	311	19	similar	similar	JJ
cord-304876-txaoz7oh	311	20	to	to	IN
cord-304876-txaoz7oh	311	21	the	the	DT
cord-304876-txaoz7oh	311	22	proofreading	proofread	VBG
cord-304876-txaoz7oh	311	23	exoribonuclease	exoribonuclease	NN
cord-304876-txaoz7oh	311	24	activities	activity	NNS
cord-304876-txaoz7oh	311	25	correlated	correlate	VBN
cord-304876-txaoz7oh	311	26	with	with	IN
cord-304876-txaoz7oh	311	27	a	a	DT
cord-304876-txaoz7oh	311	28	polymerase	polymerase	NN
cord-304876-txaoz7oh	311	29	.	.	.
cord-304876-txaoz7oh	312	1	105	105	CD
cord-304876-txaoz7oh	312	2	 	 	_SP
cord-304876-txaoz7oh	313	1	In	in	IN
cord-304876-txaoz7oh	313	2	this	this	DT
cord-304876-txaoz7oh	313	3	section	section	NN
cord-304876-txaoz7oh	313	4	,	,	,
cord-304876-txaoz7oh	313	5	we	-PRON-	PRP
cord-304876-txaoz7oh	313	6	aim	aim	VBP
cord-304876-txaoz7oh	313	7	to	to	TO
cord-304876-txaoz7oh	313	8	answer	answer	VB
cord-304876-txaoz7oh	313	9	the	the	DT
cord-304876-txaoz7oh	313	10	following	follow	VBG
cord-304876-txaoz7oh	313	11	questions	question	NNS
cord-304876-txaoz7oh	313	12	that	that	WDT
cord-304876-txaoz7oh	313	13	are	be	VBP
cord-304876-txaoz7oh	313	14	important	important	JJ
cord-304876-txaoz7oh	313	15	to	to	IN
cord-304876-txaoz7oh	313	16	medicinal	medicinal	JJ
cord-304876-txaoz7oh	313	17	chemists	chemist	NNS
cord-304876-txaoz7oh	313	18	,	,	,
cord-304876-txaoz7oh	313	19	biologists	biologist	NNS
cord-304876-txaoz7oh	313	20	,	,	,
cord-304876-txaoz7oh	313	21	and	and	CC
cord-304876-txaoz7oh	313	22	drug	drug	NN
cord-304876-txaoz7oh	313	23	developers	developer	NNS
cord-304876-txaoz7oh	313	24	working	work	VBG
cord-304876-txaoz7oh	313	25	in	in	IN
cord-304876-txaoz7oh	313	26	the	the	DT
cord-304876-txaoz7oh	313	27	field	field	NN
cord-304876-txaoz7oh	313	28	of	of	IN
cord-304876-txaoz7oh	313	29	Virology	Virology	NNP
cord-304876-txaoz7oh	313	30	.	.	.
cord-304876-txaoz7oh	314	1	Are	be	VBP
cord-304876-txaoz7oh	314	2	there	there	EX
cord-304876-txaoz7oh	314	3	clinically	clinically	RB
cord-304876-txaoz7oh	314	4	relevant	relevant	JJ
cord-304876-txaoz7oh	314	5	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	314	6	analogs	analog	NNS
cord-304876-txaoz7oh	314	7	that	that	WDT
cord-304876-txaoz7oh	314	8	are	be	VBP
cord-304876-txaoz7oh	314	9	potent	potent	JJ
cord-304876-txaoz7oh	314	10	against	against	IN
cord-304876-txaoz7oh	314	11	one	one	CD
cord-304876-txaoz7oh	314	12	or	or	CC
cord-304876-txaoz7oh	314	13	multiple	multiple	JJ
cord-304876-txaoz7oh	314	14	respiratory	respiratory	JJ
cord-304876-txaoz7oh	314	15	viruses	virus	NNS
cord-304876-txaoz7oh	314	16	?	?	.
cord-304876-txaoz7oh	315	1	How	how	WRB
cord-304876-txaoz7oh	315	2	were	be	VBD
cord-304876-txaoz7oh	315	3	these	these	DT
cord-304876-txaoz7oh	315	4	molecules	molecule	NNS
cord-304876-txaoz7oh	315	5	first	first	RB
cord-304876-txaoz7oh	315	6	identified	identify	VBN
cord-304876-txaoz7oh	315	7	,	,	,
cord-304876-txaoz7oh	315	8	and	and	CC
cord-304876-txaoz7oh	315	9	which	which	WDT
cord-304876-txaoz7oh	315	10	ones	one	NNS
cord-304876-txaoz7oh	315	11	have	have	VBP
cord-304876-txaoz7oh	315	12	been	be	VBN
cord-304876-txaoz7oh	315	13	approved	approve	VBN
cord-304876-txaoz7oh	315	14	for	for	IN
cord-304876-txaoz7oh	315	15	commercial	commercial	JJ
cord-304876-txaoz7oh	315	16	use	use	NN
cord-304876-txaoz7oh	315	17	?	?	.
cord-304876-txaoz7oh	316	1	Why	why	WRB
cord-304876-txaoz7oh	316	2	are	be	VBP
cord-304876-txaoz7oh	316	3	n't	not	RB
cord-304876-txaoz7oh	316	4	molecules	molecule	NNS
cord-304876-txaoz7oh	316	5	like	like	IN
cord-304876-txaoz7oh	316	6	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	316	7	and	and	CC
cord-304876-txaoz7oh	316	8	its	-PRON-	PRP$
cord-304876-txaoz7oh	316	9	analogs	analog	NNS
cord-304876-txaoz7oh	316	10	more	more	RBR
cord-304876-txaoz7oh	316	11	widely	widely	RB
cord-304876-txaoz7oh	316	12	used	use	VBN
cord-304876-txaoz7oh	316	13	to	to	TO
cord-304876-txaoz7oh	316	14	treat	treat	VB
cord-304876-txaoz7oh	316	15	respiratory	respiratory	JJ
cord-304876-txaoz7oh	316	16	viral	viral	JJ
cord-304876-txaoz7oh	316	17	infections	infection	NNS
cord-304876-txaoz7oh	316	18	?	?	.
cord-304876-txaoz7oh	317	1	What	what	WP
cord-304876-txaoz7oh	317	2	are	be	VBP
cord-304876-txaoz7oh	317	3	the	the	DT
cord-304876-txaoz7oh	317	4	current	current	JJ
cord-304876-txaoz7oh	317	5	approaches	approach	NNS
cord-304876-txaoz7oh	317	6	to	to	TO
cord-304876-txaoz7oh	317	7	develop	develop	VB
cord-304876-txaoz7oh	317	8	new	new	JJ
cord-304876-txaoz7oh	317	9	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	317	10	analogs	analog	NNS
cord-304876-txaoz7oh	317	11	against	against	IN
cord-304876-txaoz7oh	317	12	respiratory	respiratory	JJ
cord-304876-txaoz7oh	317	13	RNA	RNA	NNP
cord-304876-txaoz7oh	317	14	viruses	virus	NNS
cord-304876-txaoz7oh	317	15	?	?	.
cord-304876-txaoz7oh	318	1	The	the	DT
cord-304876-txaoz7oh	318	2	broad	broad	JJ
cord-304876-txaoz7oh	318	3	-	-	HYPH
cord-304876-txaoz7oh	318	4	spectrum	spectrum	NN
cord-304876-txaoz7oh	318	5	antiviral	antiviral	JJ
cord-304876-txaoz7oh	318	6	effect	effect	NN
cord-304876-txaoz7oh	318	7	of	of	IN
cord-304876-txaoz7oh	318	8	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	318	9	,	,	,
cord-304876-txaoz7oh	318	10	a	a	DT
cord-304876-txaoz7oh	318	11	guanosine	guanosine	NN
cord-304876-txaoz7oh	318	12	analog	analog	NN
cord-304876-txaoz7oh	318	13	,	,	,
cord-304876-txaoz7oh	318	14	was	be	VBD
cord-304876-txaoz7oh	318	15	first	first	RB
cord-304876-txaoz7oh	318	16	reported	report	VBN
cord-304876-txaoz7oh	318	17	in	in	IN
cord-304876-txaoz7oh	318	18	the	the	DT
cord-304876-txaoz7oh	318	19	1970s	1970	NNS
cord-304876-txaoz7oh	318	20	.	.	.
cord-304876-txaoz7oh	319	1	106	106	CD
cord-304876-txaoz7oh	319	2	,	,	,
cord-304876-txaoz7oh	319	3	107	107	CD
cord-304876-txaoz7oh	319	4	It	-PRON-	PRP
cord-304876-txaoz7oh	319	5	was	be	VBD
cord-304876-txaoz7oh	319	6	found	find	VBN
cord-304876-txaoz7oh	319	7	at	at	IN
cord-304876-txaoz7oh	319	8	the	the	DT
cord-304876-txaoz7oh	319	9	time	time	NN
cord-304876-txaoz7oh	319	10	that	that	WDT
cord-304876-txaoz7oh	319	11	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	319	12	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	319	13	16	16	CD
cord-304876-txaoz7oh	319	14	DNA	DNA	NNP
cord-304876-txaoz7oh	319	15	and	and	CC
cord-304876-txaoz7oh	319	16	RNA	RNA	NNP
cord-304876-txaoz7oh	319	17	viruses	virus	NNS
cord-304876-txaoz7oh	319	18	,	,	,
cord-304876-txaoz7oh	319	19	including	include	VBG
cord-304876-txaoz7oh	319	20	herpesviruses	herpesviruse	NNS
cord-304876-txaoz7oh	319	21	,	,	,
cord-304876-txaoz7oh	319	22	vaccinia	vaccinia	NN
cord-304876-txaoz7oh	319	23	,	,	,
cord-304876-txaoz7oh	319	24	VSV	VSV	NNP
cord-304876-txaoz7oh	319	25	,	,	,
cord-304876-txaoz7oh	319	26	as	as	RB
cord-304876-txaoz7oh	319	27	well	well	RB
cord-304876-txaoz7oh	319	28	as	as	IN
cord-304876-txaoz7oh	319	29	respiratory	respiratory	JJ
cord-304876-txaoz7oh	319	30	infections	infection	NNS
cord-304876-txaoz7oh	319	31	caused	cause	VBN
cord-304876-txaoz7oh	319	32	by	by	IN
cord-304876-txaoz7oh	319	33	influenza	influenza	NN
cord-304876-txaoz7oh	319	34	A	a	NN
cord-304876-txaoz7oh	319	35	and	and	CC
cord-304876-txaoz7oh	319	36	B	b	NN
cord-304876-txaoz7oh	319	37	viruses	virus	NNS
cord-304876-txaoz7oh	319	38	and	and	CC
cord-304876-txaoz7oh	319	39	parainfluenza	parainfluenza	NNP
cord-304876-txaoz7oh	319	40	1	1	CD
cord-304876-txaoz7oh	319	41	virus	virus	NN
cord-304876-txaoz7oh	319	42	.	.	.
cord-304876-txaoz7oh	320	1	Ribavirin	Ribavirin	NNP
cord-304876-txaoz7oh	320	2	is	be	VBZ
cord-304876-txaoz7oh	320	3	currently	currently	RB
cord-304876-txaoz7oh	320	4	approved	approve	VBN
cord-304876-txaoz7oh	320	5	for	for	IN
cord-304876-txaoz7oh	320	6	the	the	DT
cord-304876-txaoz7oh	320	7	treatment	treatment	NN
cord-304876-txaoz7oh	320	8	of	of	IN
cord-304876-txaoz7oh	320	9	chronic	chronic	JJ
cord-304876-txaoz7oh	320	10	HCV	HCV	NNP
cord-304876-txaoz7oh	320	11	infection	infection	NN
cord-304876-txaoz7oh	320	12	in	in	IN
cord-304876-txaoz7oh	320	13	combination	combination	NN
cord-304876-txaoz7oh	320	14	therapy	therapy	NN
cord-304876-txaoz7oh	320	15	and	and	CC
cord-304876-txaoz7oh	320	16	against	against	IN
cord-304876-txaoz7oh	320	17	severe	severe	JJ
cord-304876-txaoz7oh	320	18	RSV	RSV	NNP
cord-304876-txaoz7oh	320	19	infection	infection	NN
cord-304876-txaoz7oh	320	20	in	in	IN
cord-304876-txaoz7oh	320	21	monotherapy	monotherapy	NN
cord-304876-txaoz7oh	320	22	.	.	.
cord-304876-txaoz7oh	321	1	In	in	IN
cord-304876-txaoz7oh	321	2	the	the	DT
cord-304876-txaoz7oh	321	3	case	case	NN
cord-304876-txaoz7oh	321	4	of	of	IN
cord-304876-txaoz7oh	321	5	RSV	RSV	NNP
cord-304876-txaoz7oh	321	6	infection	infection	NN
cord-304876-txaoz7oh	321	7	,	,	,
cord-304876-txaoz7oh	321	8	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	321	9	is	be	VBZ
cord-304876-txaoz7oh	321	10	administered	administer	VBN
cord-304876-txaoz7oh	321	11	as	as	IN
cord-304876-txaoz7oh	321	12	a	a	DT
cord-304876-txaoz7oh	321	13	small	small	JJ
cord-304876-txaoz7oh	321	14	-	-	HYPH
cord-304876-txaoz7oh	321	15	particle	particle	NN
cord-304876-txaoz7oh	321	16	aerosol	aerosol	NN
cord-304876-txaoz7oh	321	17	that	that	WDT
cord-304876-txaoz7oh	321	18	requires	require	VBZ
cord-304876-txaoz7oh	321	19	use	use	NN
cord-304876-txaoz7oh	321	20	of	of	IN
cord-304876-txaoz7oh	321	21	a	a	DT
cord-304876-txaoz7oh	321	22	mask	mask	NN
cord-304876-txaoz7oh	321	23	and	and	CC
cord-304876-txaoz7oh	321	24	a	a	DT
cord-304876-txaoz7oh	321	25	tent	tent	NN
cord-304876-txaoz7oh	321	26	.	.	.
cord-304876-txaoz7oh	322	1	Ribavirin	Ribavirin	NNP
cord-304876-txaoz7oh	322	2	was	be	VBD
cord-304876-txaoz7oh	322	3	originally	originally	RB
cord-304876-txaoz7oh	322	4	developed	develop	VBN
cord-304876-txaoz7oh	322	5	against	against	IN
cord-304876-txaoz7oh	322	6	influenza	influenza	NN
cord-304876-txaoz7oh	322	7	based	base	VBN
cord-304876-txaoz7oh	322	8	on	on	IN
cord-304876-txaoz7oh	322	9	its	-PRON-	PRP$
cord-304876-txaoz7oh	322	10	efficacy	efficacy	NN
cord-304876-txaoz7oh	322	11	in	in	IN
cord-304876-txaoz7oh	322	12	a	a	DT
cord-304876-txaoz7oh	322	13	mouse	mouse	NN
cord-304876-txaoz7oh	322	14	model	model	NN
cord-304876-txaoz7oh	322	15	of	of	IN
cord-304876-txaoz7oh	322	16	influenza	influenza	NN
cord-304876-txaoz7oh	322	17	,	,	,
cord-304876-txaoz7oh	322	18	108,109	108,109	CD
cord-304876-txaoz7oh	322	19	but	but	CC
cord-304876-txaoz7oh	322	20	its	-PRON-	PRP$
cord-304876-txaoz7oh	322	21	effect	effect	NN
cord-304876-txaoz7oh	322	22	in	in	IN
cord-304876-txaoz7oh	322	23	human	human	JJ
cord-304876-txaoz7oh	322	24	clinical	clinical	JJ
cord-304876-txaoz7oh	322	25	trials	trial	NNS
cord-304876-txaoz7oh	322	26	was	be	VBD
cord-304876-txaoz7oh	322	27	less	less	RBR
cord-304876-txaoz7oh	322	28	clear	clear	JJ
cord-304876-txaoz7oh	322	29	,	,	,
cord-304876-txaoz7oh	322	30	so	so	CC
cord-304876-txaoz7oh	322	31	it	-PRON-	PRP
cord-304876-txaoz7oh	322	32	was	be	VBD
cord-304876-txaoz7oh	322	33	not	not	RB
cord-304876-txaoz7oh	322	34	approved	approve	VBN
cord-304876-txaoz7oh	322	35	for	for	IN
cord-304876-txaoz7oh	322	36	the	the	DT
cord-304876-txaoz7oh	322	37	treatment	treatment	NN
cord-304876-txaoz7oh	322	38	of	of	IN
cord-304876-txaoz7oh	322	39	influenza	influenza	NN
cord-304876-txaoz7oh	322	40	.	.	.
cord-304876-txaoz7oh	323	1	110	110	CD
cord-304876-txaoz7oh	324	1	Its	-PRON-	PRP$
cord-304876-txaoz7oh	324	2	clinical	clinical	JJ
cord-304876-txaoz7oh	324	3	use	use	NN
cord-304876-txaoz7oh	324	4	for	for	IN
cord-304876-txaoz7oh	324	5	the	the	DT
cord-304876-txaoz7oh	324	6	treatment	treatment	NN
cord-304876-txaoz7oh	324	7	of	of	IN
cord-304876-txaoz7oh	324	8	RSV	RSV	NNP
cord-304876-txaoz7oh	324	9	infection	infection	NN
cord-304876-txaoz7oh	324	10	via	via	IN
cord-304876-txaoz7oh	324	11	aerosol	aerosol	NN
cord-304876-txaoz7oh	324	12	delivery	delivery	NN
cord-304876-txaoz7oh	324	13	remains	remain	VBZ
cord-304876-txaoz7oh	324	14	limited	limit	VBN
cord-304876-txaoz7oh	324	15	due	due	IN
cord-304876-txaoz7oh	324	16	the	the	DT
cord-304876-txaoz7oh	324	17	inconvenient	inconvenient	JJ
cord-304876-txaoz7oh	324	18	route	route	NN
cord-304876-txaoz7oh	324	19	of	of	IN
cord-304876-txaoz7oh	324	20	administration	administration	NN
cord-304876-txaoz7oh	324	21	,	,	,
cord-304876-txaoz7oh	324	22	lack	lack	NN
cord-304876-txaoz7oh	324	23	of	of	IN
cord-304876-txaoz7oh	324	24	clear	clear	JJ
cord-304876-txaoz7oh	324	25	evidence	evidence	NN
cord-304876-txaoz7oh	324	26	for	for	IN
cord-304876-txaoz7oh	324	27	efficacy	efficacy	NN
cord-304876-txaoz7oh	324	28	,	,	,
cord-304876-txaoz7oh	324	29	and	and	CC
cord-304876-txaoz7oh	324	30	safety	safety	NN
cord-304876-txaoz7oh	324	31	concerns	concern	NNS
cord-304876-txaoz7oh	324	32	associated	associate	VBN
cord-304876-txaoz7oh	324	33	with	with	IN
cord-304876-txaoz7oh	324	34	anemia	anemia	NN
cord-304876-txaoz7oh	324	35	and	and	CC
cord-304876-txaoz7oh	324	36	risk	risk	NN
cord-304876-txaoz7oh	324	37	of	of	IN
cord-304876-txaoz7oh	324	38	teratogenicity	teratogenicity	NN
cord-304876-txaoz7oh	324	39	.	.	.
cord-304876-txaoz7oh	325	1	Studies	study	NNS
cord-304876-txaoz7oh	325	2	evaluating	evaluate	VBG
cord-304876-txaoz7oh	325	3	the	the	DT
cord-304876-txaoz7oh	325	4	mechanism	mechanism	NN
cord-304876-txaoz7oh	325	5	of	of	IN
cord-304876-txaoz7oh	325	6	action	action	NN
cord-304876-txaoz7oh	325	7	of	of	IN
cord-304876-txaoz7oh	325	8	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	325	9	have	have	VBP
cord-304876-txaoz7oh	325	10	produced	produce	VBN
cord-304876-txaoz7oh	325	11	contradictory	contradictory	JJ
cord-304876-txaoz7oh	325	12	results	result	NNS
cord-304876-txaoz7oh	325	13	.	.	.
cord-304876-txaoz7oh	326	1	It	-PRON-	PRP
cord-304876-txaoz7oh	326	2	is	be	VBZ
cord-304876-txaoz7oh	326	3	usually	usually	RB
cord-304876-txaoz7oh	326	4	acknowledged	acknowledge	VBN
cord-304876-txaoz7oh	326	5	that	that	IN
cord-304876-txaoz7oh	326	6	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	326	7	exerts	exert	VBZ
cord-304876-txaoz7oh	326	8	its	-PRON-	PRP$
cord-304876-txaoz7oh	326	9	main	main	JJ
cord-304876-txaoz7oh	326	10	effect	effect	NN
cord-304876-txaoz7oh	326	11	through	through	IN
cord-304876-txaoz7oh	326	12	its	-PRON-	PRP$
cord-304876-txaoz7oh	326	13	monophosphate	monophosphate	NN
cord-304876-txaoz7oh	326	14	metabolite	metabolite	NN
cord-304876-txaoz7oh	326	15	by	by	IN
cord-304876-txaoz7oh	326	16	inhibiting	inhibit	VBG
cord-304876-txaoz7oh	326	17	the	the	DT
cord-304876-txaoz7oh	326	18	host	host	NN
cord-304876-txaoz7oh	326	19	inosine	inosine	NN
cord-304876-txaoz7oh	326	20	monophosphate	monophosphate	NN
cord-304876-txaoz7oh	326	21	dehydrogenase	dehydrogenase	NN
cord-304876-txaoz7oh	326	22	(	(	-LRB-
cord-304876-txaoz7oh	326	23	IMPDH	IMPDH	NNP
cord-304876-txaoz7oh	326	24	)	)	-RRB-
cord-304876-txaoz7oh	326	25	enzyme	enzyme	NN
cord-304876-txaoz7oh	326	26	,	,	,
cord-304876-txaoz7oh	326	27	leading	lead	VBG
cord-304876-txaoz7oh	326	28	to	to	IN
cord-304876-txaoz7oh	326	29	depletion	depletion	NN
cord-304876-txaoz7oh	326	30	of	of	IN
cord-304876-txaoz7oh	326	31	intracellular	intracellular	JJ
cord-304876-txaoz7oh	326	32	GTP	GTP	NNP
cord-304876-txaoz7oh	326	33	pools	pool	NNS
cord-304876-txaoz7oh	326	34	,	,	,
cord-304876-txaoz7oh	326	35	which	which	WDT
cord-304876-txaoz7oh	326	36	results	result	VBZ
cord-304876-txaoz7oh	326	37	in	in	IN
cord-304876-txaoz7oh	326	38	indirect	indirect	JJ
cord-304876-txaoz7oh	326	39	inhibition	inhibition	NN
cord-304876-txaoz7oh	326	40	of	of	IN
cord-304876-txaoz7oh	326	41	RNA	RNA	NNP
cord-304876-txaoz7oh	326	42	synthesis	synthesis	NN
cord-304876-txaoz7oh	326	43	during	during	IN
cord-304876-txaoz7oh	326	44	viral	viral	JJ
cord-304876-txaoz7oh	326	45	replication	replication	NN
cord-304876-txaoz7oh	326	46	(	(	-LRB-
cord-304876-txaoz7oh	326	47	for	for	IN
cord-304876-txaoz7oh	326	48	review	review	NN
cord-304876-txaoz7oh	326	49	111	111	CD
cord-304876-txaoz7oh	326	50	)	)	-RRB-
cord-304876-txaoz7oh	326	51	.	.	.
cord-304876-txaoz7oh	327	1	The	the	DT
cord-304876-txaoz7oh	327	2	nucleoside	nucleoside	JJ
cord-304876-txaoz7oh	327	3	form	form	NN
cord-304876-txaoz7oh	327	4	of	of	IN
cord-304876-txaoz7oh	327	5	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	327	6	is	be	VBZ
cord-304876-txaoz7oh	327	7	also	also	RB
cord-304876-txaoz7oh	327	8	believed	believe	VBN
cord-304876-txaoz7oh	327	9	to	to	TO
cord-304876-txaoz7oh	327	10	enhance	enhance	VB
cord-304876-txaoz7oh	327	11	T	t	NN
cord-304876-txaoz7oh	327	12	-	-	HYPH
cord-304876-txaoz7oh	327	13	cell	cell	NN
cord-304876-txaoz7oh	327	14	-	-	HYPH
cord-304876-txaoz7oh	327	15	mediated	mediate	VBN
cord-304876-txaoz7oh	327	16	immune	immune	JJ
cord-304876-txaoz7oh	327	17	response	response	NN
cord-304876-txaoz7oh	327	18	through	through	IN
cord-304876-txaoz7oh	327	19	increased	increase	VBN
cord-304876-txaoz7oh	327	20	expression	expression	NN
cord-304876-txaoz7oh	327	21	of	of	IN
cord-304876-txaoz7oh	327	22	interferon	interferon	NN
cord-304876-txaoz7oh	327	23	-	-	HYPH
cord-304876-txaoz7oh	327	24	gamma	gamma	NN
cord-304876-txaoz7oh	327	25	and	and	CC
cord-304876-txaoz7oh	327	26	tumor	tumor	NN
cord-304876-txaoz7oh	327	27	necrosis	necrosis	NN
cord-304876-txaoz7oh	327	28	factor	factor	NN
cord-304876-txaoz7oh	327	29	-	-	HYPH
cord-304876-txaoz7oh	327	30	alpha	alpha	NN
cord-304876-txaoz7oh	327	31	.	.	.
cord-304876-txaoz7oh	327	32	111	111	CD
cord-304876-txaoz7oh	328	1	In	in	IN
cord-304876-txaoz7oh	328	2	addition	addition	NN
cord-304876-txaoz7oh	328	3	,	,	,
cord-304876-txaoz7oh	328	4	it	-PRON-	PRP
cord-304876-txaoz7oh	328	5	has	have	VBZ
cord-304876-txaoz7oh	328	6	been	be	VBN
cord-304876-txaoz7oh	328	7	proposed	propose	VBN
cord-304876-txaoz7oh	328	8	that	that	IN
cord-304876-txaoz7oh	328	9	prolonged	prolong	VBN
cord-304876-txaoz7oh	328	10	replication	replication	NN
cord-304876-txaoz7oh	328	11	of	of	IN
cord-304876-txaoz7oh	328	12	PV	pv	NN
cord-304876-txaoz7oh	328	13	in	in	IN
cord-304876-txaoz7oh	328	14	the	the	DT
cord-304876-txaoz7oh	328	15	presence	presence	NN
cord-304876-txaoz7oh	328	16	of	of	IN
cord-304876-txaoz7oh	328	17	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	328	18	increases	increase	VBZ
cord-304876-txaoz7oh	328	19	the	the	DT
cord-304876-txaoz7oh	328	20	viral	viral	JJ
cord-304876-txaoz7oh	328	21	mutation	mutation	NN
cord-304876-txaoz7oh	328	22	frequency	frequency	NN
cord-304876-txaoz7oh	328	23	and	and	CC
cord-304876-txaoz7oh	328	24	decreases	decrease	VBZ
cord-304876-txaoz7oh	328	25	infectivity	infectivity	NN
cord-304876-txaoz7oh	328	26	.	.	.
cord-304876-txaoz7oh	329	1	112	112	CD
cord-304876-txaoz7oh	330	1	One	one	CD
cord-304876-txaoz7oh	330	2	hypothesis	hypothesis	NN
cord-304876-txaoz7oh	330	3	is	be	VBZ
cord-304876-txaoz7oh	330	4	that	that	IN
cord-304876-txaoz7oh	330	5	the	the	DT
cord-304876-txaoz7oh	330	6	mutagenic	mutagenic	JJ
cord-304876-txaoz7oh	330	7	effect	effect	NN
cord-304876-txaoz7oh	330	8	of	of	IN
cord-304876-txaoz7oh	330	9	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	330	10	is	be	VBZ
cord-304876-txaoz7oh	330	11	caused	cause	VBN
cord-304876-txaoz7oh	330	12	by	by	IN
cord-304876-txaoz7oh	330	13	its	-PRON-	PRP$
cord-304876-txaoz7oh	330	14	triphosphate	triphosphate	NN
cord-304876-txaoz7oh	330	15	form	form	NN
cord-304876-txaoz7oh	330	16	that	that	WDT
cord-304876-txaoz7oh	330	17	is	be	VBZ
cord-304876-txaoz7oh	330	18	recognized	recognize	VBN
cord-304876-txaoz7oh	330	19	by	by	IN
cord-304876-txaoz7oh	330	20	the	the	DT
cord-304876-txaoz7oh	330	21	viral	viral	JJ
cord-304876-txaoz7oh	330	22	RNA	RNA	NNP
cord-304876-txaoz7oh	330	23	polymerase	polymerase	NN
cord-304876-txaoz7oh	330	24	.	.	.
cord-304876-txaoz7oh	331	1	112	112	CD
cord-304876-txaoz7oh	332	1	Once	once	RB
cord-304876-txaoz7oh	332	2	incorporated	incorporate	VBN
cord-304876-txaoz7oh	332	3	into	into	IN
cord-304876-txaoz7oh	332	4	the	the	DT
cord-304876-txaoz7oh	332	5	viral	viral	JJ
cord-304876-txaoz7oh	332	6	genome	genome	NN
cord-304876-txaoz7oh	332	7	,	,	,
cord-304876-txaoz7oh	332	8	ribavirin	ribavirin	FW
cord-304876-txaoz7oh	332	9	monophosphate	monophosphate	NN
cord-304876-txaoz7oh	332	10	could	could	MD
cord-304876-txaoz7oh	332	11	equally	equally	RB
cord-304876-txaoz7oh	332	12	base	base	JJ
cord-304876-txaoz7oh	332	13	pair	pair	NN
cord-304876-txaoz7oh	332	14	with	with	IN
cord-304876-txaoz7oh	332	15	cytidine	cytidine	NNP
cord-304876-txaoz7oh	332	16	and	and	CC
cord-304876-txaoz7oh	332	17	uridine	uridine	NN
cord-304876-txaoz7oh	332	18	,	,	,
cord-304876-txaoz7oh	332	19	therefore	therefore	RB
cord-304876-txaoz7oh	332	20	causing	cause	VBG
cord-304876-txaoz7oh	332	21	random	random	JJ
cord-304876-txaoz7oh	332	22	mutations	mutation	NNS
cord-304876-txaoz7oh	332	23	throughout	throughout	IN
cord-304876-txaoz7oh	332	24	the	the	DT
cord-304876-txaoz7oh	332	25	viral	viral	JJ
cord-304876-txaoz7oh	332	26	genome	genome	NN
cord-304876-txaoz7oh	332	27	.	.	.
cord-304876-txaoz7oh	333	1	Ribo	ribo	NN
cord-304876-txaoz7oh	333	2	-	-	HYPH
cord-304876-txaoz7oh	333	3	cytidine	cytidine	NN
cord-304876-txaoz7oh	333	4	and	and	CC
cord-304876-txaoz7oh	333	5	adenosine	adenosine	NN
cord-304876-txaoz7oh	333	6	analogs	analog	NNS
cord-304876-txaoz7oh	333	7	containing	contain	VBG
cord-304876-txaoz7oh	333	8	a	a	DT
cord-304876-txaoz7oh	333	9	methyl	methyl	NN
cord-304876-txaoz7oh	333	10	group	group	NN
cord-304876-txaoz7oh	333	11	at	at	IN
cord-304876-txaoz7oh	333	12	the	the	DT
cord-304876-txaoz7oh	333	13	2	2	CD
cord-304876-txaoz7oh	333	14	0	0	CD
cord-304876-txaoz7oh	333	15	-position	-position	NN
cord-304876-txaoz7oh	333	16	on	on	IN
cord-304876-txaoz7oh	333	17	the	the	DT
cord-304876-txaoz7oh	333	18	ribose	ribose	NN
cord-304876-txaoz7oh	333	19	are	be	VBP
cord-304876-txaoz7oh	333	20	known	know	VBN
cord-304876-txaoz7oh	333	21	inhibitors	inhibitor	NNS
cord-304876-txaoz7oh	333	22	of	of	IN
cord-304876-txaoz7oh	333	23	HCV	HCV	NNP
cord-304876-txaoz7oh	333	24	and	and	CC
cord-304876-txaoz7oh	333	25	other	other	JJ
cord-304876-txaoz7oh	333	26	related	related	JJ
cord-304876-txaoz7oh	333	27	members	member	NNS
cord-304876-txaoz7oh	333	28	of	of	IN
cord-304876-txaoz7oh	333	29	the	the	DT
cord-304876-txaoz7oh	333	30	Flaviviridae	Flaviviridae	NNP
cord-304876-txaoz7oh	333	31	family	family	NN
cord-304876-txaoz7oh	333	32	.	.	.
cord-304876-txaoz7oh	334	1	[	[	-LRB-
cord-304876-txaoz7oh	334	2	113	113	CD
cord-304876-txaoz7oh	334	3	]	]	-RRB-
cord-304876-txaoz7oh	334	4	[	[	-LRB-
cord-304876-txaoz7oh	334	5	114	114	CD
cord-304876-txaoz7oh	334	6	]	]	-RRB-
cord-304876-txaoz7oh	334	7	[	[	-LRB-
cord-304876-txaoz7oh	334	8	115	115	CD
cord-304876-txaoz7oh	334	9	]	]	-RRB-
cord-304876-txaoz7oh	334	10	[	[	-LRB-
cord-304876-txaoz7oh	334	11	116	116	CD
cord-304876-txaoz7oh	334	12	]	]	-RRB-
cord-304876-txaoz7oh	334	13	[	[	-LRB-
cord-304876-txaoz7oh	334	14	117	117	CD
cord-304876-txaoz7oh	334	15	]	]	-RRB-
cord-304876-txaoz7oh	334	16	[	[	-LRB-
cord-304876-txaoz7oh	334	17	118	118	CD
cord-304876-txaoz7oh	334	18	]	]	-RRB-
cord-304876-txaoz7oh	334	19	[	[	-LRB-
cord-304876-txaoz7oh	334	20	119	119	CD
cord-304876-txaoz7oh	334	21	]	]	-RRB-
cord-304876-txaoz7oh	334	22	One	one	CD
cord-304876-txaoz7oh	334	23	of	of	IN
cord-304876-txaoz7oh	334	24	the	the	DT
cord-304876-txaoz7oh	334	25	most	most	RBS
cord-304876-txaoz7oh	334	26	potent	potent	JJ
cord-304876-txaoz7oh	334	27	molecules	molecule	NNS
cord-304876-txaoz7oh	334	28	of	of	IN
cord-304876-txaoz7oh	334	29	this	this	DT
cord-304876-txaoz7oh	334	30	series	series	NN
cord-304876-txaoz7oh	334	31	,	,	,
cord-304876-txaoz7oh	334	32	7-deaza-2	7-deaza-2	CD
cord-304876-txaoz7oh	334	33	0	0	CD
cord-304876-txaoz7oh	335	1	-C	-C	:
cord-304876-txaoz7oh	335	2	-	-	HYPH
cord-304876-txaoz7oh	335	3	methyladenosine	methyladenosine	NNP
cord-304876-txaoz7oh	335	4	(	(	-LRB-
cord-304876-txaoz7oh	335	5	7DMA	7DMA	NNP
cord-304876-txaoz7oh	335	6	,	,	,
cord-304876-txaoz7oh	335	7	MK-0608	MK-0608	NNP
cord-304876-txaoz7oh	335	8	)	)	-RRB-
cord-304876-txaoz7oh	335	9	,	,	,
cord-304876-txaoz7oh	335	10	was	be	VBD
cord-304876-txaoz7oh	335	11	once	once	RB
cord-304876-txaoz7oh	335	12	a	a	DT
cord-304876-txaoz7oh	335	13	development	development	NN
cord-304876-txaoz7oh	335	14	candidate	candidate	NN
cord-304876-txaoz7oh	335	15	for	for	IN
cord-304876-txaoz7oh	335	16	the	the	DT
cord-304876-txaoz7oh	335	17	treatment	treatment	NN
cord-304876-txaoz7oh	335	18	of	of	IN
cord-304876-txaoz7oh	335	19	HCV	HCV	NNP
cord-304876-txaoz7oh	335	20	infection	infection	NN
cord-304876-txaoz7oh	335	21	(	(	-LRB-
cord-304876-txaoz7oh	335	22	Figure	figure	NN
cord-304876-txaoz7oh	335	23	5	5	CD
cord-304876-txaoz7oh	335	24	)	)	-RRB-
cord-304876-txaoz7oh	335	25	.	.	.
cord-304876-txaoz7oh	336	1	117	117	CD
cord-304876-txaoz7oh	337	1	,	,	,
cord-304876-txaoz7oh	337	2	120	120	CD
cord-304876-txaoz7oh	338	1	The	the	DT
cord-304876-txaoz7oh	338	2	adenosine	adenosine	NN
cord-304876-txaoz7oh	338	3	analog	analog	NN
cord-304876-txaoz7oh	338	4	7DMA	7dma	XX
cord-304876-txaoz7oh	338	5	also	also	RB
cord-304876-txaoz7oh	338	6	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	338	7	HRV	HRV	NNP
cord-304876-txaoz7oh	338	8	type	type	NN
cord-304876-txaoz7oh	338	9	A	a	DT
cord-304876-txaoz7oh	338	10	infection	infection	NN
cord-304876-txaoz7oh	338	11	in	in	IN
cord-304876-txaoz7oh	338	12	vitro	vitro	FW
cord-304876-txaoz7oh	338	13	,	,	,
cord-304876-txaoz7oh	338	14	with	with	IN
cord-304876-txaoz7oh	338	15	EC	EC	NNP
cord-304876-txaoz7oh	338	16	50	50	CD
cord-304876-txaoz7oh	338	17	values	value	NNS
cord-304876-txaoz7oh	338	18	ranging	range	VBG
cord-304876-txaoz7oh	338	19	from	from	IN
cord-304876-txaoz7oh	338	20	2	2	CD
cord-304876-txaoz7oh	338	21	to	to	TO
cord-304876-txaoz7oh	338	22	12	12	CD
cord-304876-txaoz7oh	338	23	mM.	mM.	NNS
cord-304876-txaoz7oh	338	24	121	121	CD
cord-304876-txaoz7oh	339	1	A	a	DT
cord-304876-txaoz7oh	339	2	subgenomic	subgenomic	JJ
cord-304876-txaoz7oh	339	3	replicon	replicon	NN
cord-304876-txaoz7oh	339	4	assay	assay	NN
cord-304876-txaoz7oh	339	5	was	be	VBD
cord-304876-txaoz7oh	339	6	used	use	VBN
cord-304876-txaoz7oh	339	7	in	in	IN
cord-304876-txaoz7oh	339	8	transient	transient	JJ
cord-304876-txaoz7oh	339	9	transfection	transfection	NN
cord-304876-txaoz7oh	339	10	experiments	experiment	NNS
cord-304876-txaoz7oh	339	11	to	to	TO
cord-304876-txaoz7oh	339	12	demonstrate	demonstrate	VB
cord-304876-txaoz7oh	339	13	that	that	IN
cord-304876-txaoz7oh	339	14	7DMA	7DMA	NNP
cord-304876-txaoz7oh	339	15	is	be	VBZ
cord-304876-txaoz7oh	339	16	equipotent	equipotent	JJ
cord-304876-txaoz7oh	339	17	against	against	IN
cord-304876-txaoz7oh	339	18	multiple	multiple	JJ
cord-304876-txaoz7oh	339	19	strains	strain	NNS
cord-304876-txaoz7oh	339	20	of	of	IN
cord-304876-txaoz7oh	340	1	HRV	HRV	NNP
cord-304876-txaoz7oh	340	2	type	type	NN
cord-304876-txaoz7oh	340	3	C.	C.	NNP
cord-304876-txaoz7oh	340	4	This	this	DT
cord-304876-txaoz7oh	340	5	important	important	JJ
cord-304876-txaoz7oh	340	6	proof	proof	NN
cord-304876-txaoz7oh	340	7	-	-	HYPH
cord-304876-txaoz7oh	340	8	of	of	IN
cord-304876-txaoz7oh	340	9	-	-	HYPH
cord-304876-txaoz7oh	340	10	concept	concept	NN
cord-304876-txaoz7oh	340	11	experiment	experiment	NN
cord-304876-txaoz7oh	340	12	demonstrated	demonstrate	VBD
cord-304876-txaoz7oh	340	13	that	that	IN
cord-304876-txaoz7oh	340	14	2	2	CD
cord-304876-txaoz7oh	340	15	0	0	NFP
cord-304876-txaoz7oh	340	16	-methyl	-methyl	NNP
cord-304876-txaoz7oh	340	17	nucleosides	nucleoside	NNS
cord-304876-txaoz7oh	340	18	prevent	prevent	VBP
cord-304876-txaoz7oh	340	19	picornavirus	picornavirus	NN
cord-304876-txaoz7oh	340	20	replication	replication	NN
cord-304876-txaoz7oh	340	21	,	,	,
cord-304876-txaoz7oh	340	22	most	most	RBS
cord-304876-txaoz7oh	340	23	likely	likely	RB
cord-304876-txaoz7oh	340	24	by	by	IN
cord-304876-txaoz7oh	340	25	inhibiting	inhibit	VBG
cord-304876-txaoz7oh	340	26	the	the	DT
cord-304876-txaoz7oh	340	27	viral	viral	JJ
cord-304876-txaoz7oh	340	28	RNA	RNA	NNP
cord-304876-txaoz7oh	340	29	polymerase	polymerase	NN
cord-304876-txaoz7oh	340	30	function	function	NN
cord-304876-txaoz7oh	340	31	.	.	.
cord-304876-txaoz7oh	341	1	This	this	DT
cord-304876-txaoz7oh	341	2	class	class	NN
cord-304876-txaoz7oh	341	3	effect	effect	NN
cord-304876-txaoz7oh	341	4	was	be	VBD
cord-304876-txaoz7oh	341	5	confirmed	confirm	VBN
cord-304876-txaoz7oh	341	6	with	with	IN
cord-304876-txaoz7oh	341	7	NITD008	NITD008	NNP
cord-304876-txaoz7oh	341	8	,	,	,
cord-304876-txaoz7oh	341	9	another	another	DT
cord-304876-txaoz7oh	341	10	adenosine	adenosine	NN
cord-304876-txaoz7oh	341	11	analog	analog	NN
cord-304876-txaoz7oh	341	12	containing	contain	VBG
cord-304876-txaoz7oh	341	13	a	a	DT
cord-304876-txaoz7oh	341	14	2	2	CD
cord-304876-txaoz7oh	341	15	0	0	CD
cord-304876-txaoz7oh	341	16	-C	-c	ADD
cord-304876-txaoz7oh	341	17	-	-	HYPH
cord-304876-txaoz7oh	341	18	ethynyl	ethynyl	NN
cord-304876-txaoz7oh	341	19	on	on	IN
cord-304876-txaoz7oh	341	20	its	-PRON-	PRP$
cord-304876-txaoz7oh	341	21	2	2	CD
cord-304876-txaoz7oh	341	22	0	0	CD
cord-304876-txaoz7oh	341	23	-ribose	-ribose	:
cord-304876-txaoz7oh	341	24	(	(	-LRB-
cord-304876-txaoz7oh	341	25	Figure	figure	NN
cord-304876-txaoz7oh	341	26	5	5	CD
cord-304876-txaoz7oh	341	27	)	)	-RRB-
cord-304876-txaoz7oh	341	28	.	.	.
cord-304876-txaoz7oh	342	1	Just	just	RB
cord-304876-txaoz7oh	342	2	like	like	IN
cord-304876-txaoz7oh	342	3	7DMA	7dma	CD
cord-304876-txaoz7oh	342	4	,	,	,
cord-304876-txaoz7oh	342	5	NITD008	NITD008	NNP
cord-304876-txaoz7oh	342	6	was	be	VBD
cord-304876-txaoz7oh	342	7	previously	previously	RB
cord-304876-txaoz7oh	342	8	known	know	VBN
cord-304876-txaoz7oh	342	9	to	to	TO
cord-304876-txaoz7oh	342	10	inhibit	inhibit	VB
cord-304876-txaoz7oh	342	11	Flaviviruses	Flaviviruses	NNP
cord-304876-txaoz7oh	342	12	,	,	,
cord-304876-txaoz7oh	342	13	and	and	CC
cord-304876-txaoz7oh	342	14	was	be	VBD
cord-304876-txaoz7oh	342	15	once	once	RB
cord-304876-txaoz7oh	342	16	a	a	DT
cord-304876-txaoz7oh	342	17	development	development	NN
cord-304876-txaoz7oh	342	18	candidate	candidate	NN
cord-304876-txaoz7oh	342	19	for	for	IN
cord-304876-txaoz7oh	342	20	the	the	DT
cord-304876-txaoz7oh	342	21	treatment	treatment	NN
cord-304876-txaoz7oh	342	22	of	of	IN
cord-304876-txaoz7oh	342	23	dengue	dengue	NN
cord-304876-txaoz7oh	342	24	infection	infection	NN
cord-304876-txaoz7oh	342	25	.	.	.
cord-304876-txaoz7oh	343	1	122	122	CD
cord-304876-txaoz7oh	344	1	NITD008	NITD008	NNP
cord-304876-txaoz7oh	344	2	blocks	block	VBZ
cord-304876-txaoz7oh	344	3	the	the	DT
cord-304876-txaoz7oh	344	4	replication	replication	NN
cord-304876-txaoz7oh	344	5	of	of	IN
cord-304876-txaoz7oh	344	6	dengue	dengue	NN
cord-304876-txaoz7oh	344	7	virus	virus	NN
cord-304876-txaoz7oh	344	8	in	in	IN
cord-304876-txaoz7oh	344	9	cell	cell	NN
cord-304876-txaoz7oh	344	10	culture	culture	NN
cord-304876-txaoz7oh	344	11	and	and	CC
cord-304876-txaoz7oh	344	12	in	in	IN
cord-304876-txaoz7oh	344	13	mice	mouse	NNS
cord-304876-txaoz7oh	344	14	by	by	IN
cord-304876-txaoz7oh	344	15	inhibiting	inhibit	VBG
cord-304876-txaoz7oh	344	16	the	the	DT
cord-304876-txaoz7oh	344	17	RdRp	RdRp	NNP
cord-304876-txaoz7oh	344	18	activity	activity	NN
cord-304876-txaoz7oh	344	19	of	of	IN
cord-304876-txaoz7oh	344	20	the	the	DT
cord-304876-txaoz7oh	344	21	NS5	ns5	JJ
cord-304876-txaoz7oh	344	22	protein	protein	NN
cord-304876-txaoz7oh	344	23	.	.	.
cord-304876-txaoz7oh	345	1	122	122	CD
cord-304876-txaoz7oh	345	2	,	,	,
cord-304876-txaoz7oh	345	3	123	123	CD
cord-304876-txaoz7oh	346	1	Therefore	therefore	RB
cord-304876-txaoz7oh	346	2	,	,	,
cord-304876-txaoz7oh	346	3	the	the	DT
cord-304876-txaoz7oh	346	4	possibility	possibility	NN
cord-304876-txaoz7oh	346	5	that	that	IN
cord-304876-txaoz7oh	346	6	NITD008	NITD008	NNP
cord-304876-txaoz7oh	346	7	would	would	MD
cord-304876-txaoz7oh	346	8	inhibit	inhibit	VB
cord-304876-txaoz7oh	346	9	other	other	JJ
cord-304876-txaoz7oh	346	10	(	(	-LRB-
cord-304876-txaoz7oh	347	1	þ)ssRNA	þ)ssRNA	NNP
cord-304876-txaoz7oh	347	2	viruses	virus	NNS
cord-304876-txaoz7oh	347	3	is	be	VBZ
cord-304876-txaoz7oh	347	4	not	not	RB
cord-304876-txaoz7oh	347	5	unexpected	unexpected	JJ
cord-304876-txaoz7oh	347	6	.	.	.
cord-304876-txaoz7oh	348	1	Indeed	indeed	RB
cord-304876-txaoz7oh	348	2	,	,	,
cord-304876-txaoz7oh	348	3	NITD008	NITD008	NNP
cord-304876-txaoz7oh	348	4	blocks	block	VBZ
cord-304876-txaoz7oh	348	5	the	the	DT
cord-304876-txaoz7oh	348	6	replication	replication	NN
cord-304876-txaoz7oh	348	7	of	of	IN
cord-304876-txaoz7oh	348	8	EV71	EV71	NNP
cord-304876-txaoz7oh	348	9	,	,	,
cord-304876-txaoz7oh	348	10	another	another	DT
cord-304876-txaoz7oh	348	11	enterovirus	enterovirus	NN
cord-304876-txaoz7oh	348	12	-	-	HYPH
cord-304876-txaoz7oh	348	13	related	relate	VBN
cord-304876-txaoz7oh	348	14	to	to	IN
cord-304876-txaoz7oh	348	15	rhinovirus	rhinovirus	NN
cord-304876-txaoz7oh	348	16	.	.	.
cord-304876-txaoz7oh	349	1	124	124	CD
cord-304876-txaoz7oh	350	1	This	this	DT
cord-304876-txaoz7oh	350	2	in	in	IN
cord-304876-txaoz7oh	350	3	vitro	vitro	FW
cord-304876-txaoz7oh	350	4	antiviral	antiviral	JJ
cord-304876-txaoz7oh	350	5	effect	effect	NN
cord-304876-txaoz7oh	350	6	was	be	VBD
cord-304876-txaoz7oh	350	7	confirmed	confirm	VBN
cord-304876-txaoz7oh	350	8	in	in	IN
cord-304876-txaoz7oh	350	9	a	a	DT
cord-304876-txaoz7oh	350	10	separate	separate	JJ
cord-304876-txaoz7oh	350	11	study	study	NN
cord-304876-txaoz7oh	350	12	that	that	WDT
cord-304876-txaoz7oh	350	13	also	also	RB
cord-304876-txaoz7oh	350	14	demonstrated	demonstrate	VBD
cord-304876-txaoz7oh	350	15	in	in	IN
cord-304876-txaoz7oh	350	16	vivo	vivo	NN
cord-304876-txaoz7oh	350	17	efficacy	efficacy	NN
cord-304876-txaoz7oh	350	18	.	.	.
cord-304876-txaoz7oh	351	1	125	125	CD
cord-304876-txaoz7oh	351	2	Investigators	investigator	NNS
cord-304876-txaoz7oh	351	3	in	in	IN
cord-304876-txaoz7oh	351	4	the	the	DT
cord-304876-txaoz7oh	351	5	latter	latter	JJ
cord-304876-txaoz7oh	351	6	study	study	NN
cord-304876-txaoz7oh	351	7	infected	infect	VBD
cord-304876-txaoz7oh	351	8	2-week	2-week	CD
cord-304876-txaoz7oh	351	9	-	-	HYPH
cord-304876-txaoz7oh	351	10	old	old	JJ
cord-304876-txaoz7oh	351	11	AG129	AG129	NNS
cord-304876-txaoz7oh	351	12	immunocompromised	immunocompromised	JJ
cord-304876-txaoz7oh	351	13	mice	mouse	NNS
cord-304876-txaoz7oh	351	14	with	with	IN
cord-304876-txaoz7oh	351	15	EV71	EV71	NNP
cord-304876-txaoz7oh	351	16	by	by	IN
cord-304876-txaoz7oh	351	17	intraperitoneal	intraperitoneal	JJ
cord-304876-txaoz7oh	351	18	inoculation	inoculation	NN
cord-304876-txaoz7oh	351	19	.	.	.
cord-304876-txaoz7oh	352	1	Treatment	treatment	NN
cord-304876-txaoz7oh	352	2	of	of	IN
cord-304876-txaoz7oh	352	3	the	the	DT
cord-304876-txaoz7oh	352	4	infected	infected	JJ
cord-304876-txaoz7oh	352	5	animals	animal	NNS
cord-304876-txaoz7oh	352	6	with	with	IN
cord-304876-txaoz7oh	352	7	NITD008	NITD008	NNP
cord-304876-txaoz7oh	352	8	given	give	VBN
cord-304876-txaoz7oh	352	9	orally	orally	RB
cord-304876-txaoz7oh	352	10	at	at	IN
cord-304876-txaoz7oh	352	11	5	5	CD
cord-304876-txaoz7oh	352	12	mg	mg	NNP
cord-304876-txaoz7oh	352	13	/	/	SYM
cord-304876-txaoz7oh	352	14	kg	kg	NNS
cord-304876-txaoz7oh	352	15	twice	twice	PDT
cord-304876-txaoz7oh	352	16	a	a	DT
cord-304876-txaoz7oh	352	17	day	day	NN
cord-304876-txaoz7oh	352	18	for	for	IN
cord-304876-txaoz7oh	352	19	4	4	CD
cord-304876-txaoz7oh	352	20	days	day	NNS
cord-304876-txaoz7oh	353	1	resulted	result	VBD
cord-304876-txaoz7oh	353	2	in	in	IN
cord-304876-txaoz7oh	353	3	100	100	CD
cord-304876-txaoz7oh	353	4	%	%	NN
cord-304876-txaoz7oh	353	5	survival	survival	NN
cord-304876-txaoz7oh	353	6	at	at	IN
cord-304876-txaoz7oh	353	7	the	the	DT
cord-304876-txaoz7oh	353	8	end	end	NN
cord-304876-txaoz7oh	353	9	of	of	IN
cord-304876-txaoz7oh	353	10	the	the	DT
cord-304876-txaoz7oh	353	11	study	study	NN
cord-304876-txaoz7oh	353	12	,	,	,
cord-304876-txaoz7oh	353	13	compared	compare	VBN
cord-304876-txaoz7oh	353	14	to	to	IN
cord-304876-txaoz7oh	353	15	0	0	CD
cord-304876-txaoz7oh	353	16	%	%	NN
cord-304876-txaoz7oh	353	17	survival	survival	NN
cord-304876-txaoz7oh	353	18	for	for	IN
cord-304876-txaoz7oh	353	19	the	the	DT
cord-304876-txaoz7oh	353	20	vehicle	vehicle	NN
cord-304876-txaoz7oh	353	21	control	control	NN
cord-304876-txaoz7oh	353	22	group	group	NN
cord-304876-txaoz7oh	353	23	.	.	.
cord-304876-txaoz7oh	354	1	NITD008	NITD008	NNP
cord-304876-txaoz7oh	354	2	can	can	MD
cord-304876-txaoz7oh	354	3	not	not	RB
cord-304876-txaoz7oh	354	4	be	be	VB
cord-304876-txaoz7oh	354	5	developed	develop	VBN
cord-304876-txaoz7oh	354	6	in	in	IN
cord-304876-txaoz7oh	354	7	the	the	DT
cord-304876-txaoz7oh	354	8	clinic	clinic	NN
cord-304876-txaoz7oh	354	9	due	due	IN
cord-304876-txaoz7oh	354	10	to	to	IN
cord-304876-txaoz7oh	354	11	severe	severe	JJ
cord-304876-txaoz7oh	354	12	toxicity	toxicity	NN
cord-304876-txaoz7oh	354	13	seen	see	VBN
cord-304876-txaoz7oh	354	14	in	in	IN
cord-304876-txaoz7oh	354	15	14-day	14-day	CD
cord-304876-txaoz7oh	354	16	studies	study	NNS
cord-304876-txaoz7oh	354	17	in	in	IN
cord-304876-txaoz7oh	354	18	rats	rat	NNS
cord-304876-txaoz7oh	354	19	and	and	CC
cord-304876-txaoz7oh	354	20	dogs	dog	NNS
cord-304876-txaoz7oh	354	21	.	.	.
cord-304876-txaoz7oh	355	1	122	122	CD
cord-304876-txaoz7oh	356	1	However	however	RB
cord-304876-txaoz7oh	356	2	,	,	,
cord-304876-txaoz7oh	356	3	the	the	DT
cord-304876-txaoz7oh	356	4	results	result	NNS
cord-304876-txaoz7oh	356	5	summarized	summarize	VBN
cord-304876-txaoz7oh	356	6	here	here	RB
cord-304876-txaoz7oh	356	7	indicate	indicate	VBP
cord-304876-txaoz7oh	356	8	that	that	IN
cord-304876-txaoz7oh	356	9	nucleoside	nucleoside	JJ
cord-304876-txaoz7oh	356	10	analogs	analog	NNS
cord-304876-txaoz7oh	356	11	targeting	target	VBG
cord-304876-txaoz7oh	356	12	the	the	DT
cord-304876-txaoz7oh	356	13	viral	viral	JJ
cord-304876-txaoz7oh	356	14	RNA	RNA	NNP
cord-304876-txaoz7oh	356	15	polymerase	polymerase	NN
cord-304876-txaoz7oh	356	16	of	of	IN
cord-304876-txaoz7oh	356	17	rhinovirus	rhinovirus	NN
cord-304876-txaoz7oh	356	18	,	,	,
cord-304876-txaoz7oh	356	19	EV71	EV71	NNP
cord-304876-txaoz7oh	356	20	,	,	,
cord-304876-txaoz7oh	356	21	and	and	CC
cord-304876-txaoz7oh	356	22	other	other	JJ
cord-304876-txaoz7oh	356	23	enteroviruses	enterovirus	NNS
cord-304876-txaoz7oh	356	24	have	have	VBP
cord-304876-txaoz7oh	356	25	the	the	DT
cord-304876-txaoz7oh	356	26	potential	potential	NN
cord-304876-txaoz7oh	356	27	to	to	TO
cord-304876-txaoz7oh	356	28	be	be	VB
cord-304876-txaoz7oh	356	29	efficacious	efficacious	JJ
cord-304876-txaoz7oh	356	30	in	in	IN
cord-304876-txaoz7oh	356	31	preclinical	preclinical	JJ
cord-304876-txaoz7oh	356	32	animal	animal	NN
cord-304876-txaoz7oh	356	33	models	model	NNS
cord-304876-txaoz7oh	356	34	,	,	,
cord-304876-txaoz7oh	356	35	providing	provide	VBG
cord-304876-txaoz7oh	356	36	a	a	DT
cord-304876-txaoz7oh	356	37	rationale	rationale	NN
cord-304876-txaoz7oh	356	38	to	to	TO
cord-304876-txaoz7oh	356	39	conduct	conduct	VB
cord-304876-txaoz7oh	356	40	human	human	JJ
cord-304876-txaoz7oh	356	41	studies	study	NNS
cord-304876-txaoz7oh	356	42	with	with	IN
cord-304876-txaoz7oh	356	43	safer	safe	JJR
cord-304876-txaoz7oh	356	44	molecules	molecule	NNS
cord-304876-txaoz7oh	356	45	sharing	share	VBG
cord-304876-txaoz7oh	356	46	the	the	DT
cord-304876-txaoz7oh	356	47	same	same	JJ
cord-304876-txaoz7oh	356	48	mode	mode	NN
cord-304876-txaoz7oh	356	49	of	of	IN
cord-304876-txaoz7oh	356	50	action	action	NN
cord-304876-txaoz7oh	356	51	.	.	.
cord-304876-txaoz7oh	357	1	2	2	LS
cord-304876-txaoz7oh	357	2	0	0	CD
cord-304876-txaoz7oh	358	1	-Deoxy-2	-Deoxy-2	VBD
cord-304876-txaoz7oh	358	2	0	0	CD
cord-304876-txaoz7oh	358	3	-fluoro	-fluoro	NNS
cord-304876-txaoz7oh	358	4	nucleosides	nucleoside	NNS
cord-304876-txaoz7oh	358	5	for	for	IN
cord-304876-txaoz7oh	358	6	influenza	influenza	NN
cord-304876-txaoz7oh	358	7	Fluorinated	fluorinate	VBN
cord-304876-txaoz7oh	358	8	nucleosides	nucleoside	NNS
cord-304876-txaoz7oh	358	9	are	be	VBP
cord-304876-txaoz7oh	358	10	well	well	RB
cord-304876-txaoz7oh	358	11	known	know	VBN
cord-304876-txaoz7oh	358	12	for	for	IN
cord-304876-txaoz7oh	358	13	their	-PRON-	PRP$
cord-304876-txaoz7oh	358	14	antiviral	antiviral	JJ
cord-304876-txaoz7oh	358	15	and	and	CC
cord-304876-txaoz7oh	358	16	anticancer	anticancer	JJ
cord-304876-txaoz7oh	358	17	properties	property	NNS
cord-304876-txaoz7oh	358	18	(	(	-LRB-
cord-304876-txaoz7oh	358	19	for	for	IN
cord-304876-txaoz7oh	358	20	review	review	NN
cord-304876-txaoz7oh	358	21	126	126	CD
cord-304876-txaoz7oh	358	22	)	)	-RRB-
cord-304876-txaoz7oh	358	23	.	.	.
cord-304876-txaoz7oh	359	1	In	in	IN
cord-304876-txaoz7oh	359	2	particular	particular	JJ
cord-304876-txaoz7oh	359	3	,	,	,
cord-304876-txaoz7oh	359	4	2	2	CD
cord-304876-txaoz7oh	359	5	0	0	CD
cord-304876-txaoz7oh	359	6	-deoxy-2	-deoxy-2	ADD
cord-304876-txaoz7oh	359	7	0	0	CD
cord-304876-txaoz7oh	359	8	-fluoro	-fluoro	NN
cord-304876-txaoz7oh	359	9	guanosine	guanosine	NN
cord-304876-txaoz7oh	359	10	(	(	-LRB-
cord-304876-txaoz7oh	359	11	2	2	CD
cord-304876-txaoz7oh	359	12	0	0	CD
cord-304876-txaoz7oh	359	13	FdG	fdg	NN
cord-304876-txaoz7oh	359	14	)	)	-RRB-
cord-304876-txaoz7oh	359	15	was	be	VBD
cord-304876-txaoz7oh	359	16	at	at	IN
cord-304876-txaoz7oh	359	17	one	one	CD
cord-304876-txaoz7oh	359	18	time	time	NN
cord-304876-txaoz7oh	359	19	considered	consider	VBD
cord-304876-txaoz7oh	359	20	a	a	DT
cord-304876-txaoz7oh	359	21	potential	potential	JJ
cord-304876-txaoz7oh	359	22	candidate	candidate	NN
cord-304876-txaoz7oh	359	23	for	for	IN
cord-304876-txaoz7oh	359	24	influenza	influenza	NN
cord-304876-txaoz7oh	359	25	treatment	treatment	NN
cord-304876-txaoz7oh	359	26	(	(	-LRB-
cord-304876-txaoz7oh	359	27	Figure	figure	NN
cord-304876-txaoz7oh	359	28	5	5	CD
cord-304876-txaoz7oh	359	29	)	)	-RRB-
cord-304876-txaoz7oh	359	30	.	.	.
cord-304876-txaoz7oh	360	1	In	in	IN
cord-304876-txaoz7oh	360	2	vitro	vitro	FW
cord-304876-txaoz7oh	360	3	,	,	,
cord-304876-txaoz7oh	360	4	2	2	CD
cord-304876-txaoz7oh	360	5	0	0	CD
cord-304876-txaoz7oh	360	6	FdG	fdg	NN
cord-304876-txaoz7oh	360	7	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	360	8	influenza	influenza	NN
cord-304876-txaoz7oh	360	9	A	a	DT
cord-304876-txaoz7oh	360	10	virus	virus	NN
cord-304876-txaoz7oh	360	11	replication	replication	NN
cord-304876-txaoz7oh	360	12	with	with	IN
cord-304876-txaoz7oh	360	13	an	an	DT
cord-304876-txaoz7oh	360	14	EC	EC	NNP
cord-304876-txaoz7oh	360	15	50	50	CD
cord-304876-txaoz7oh	360	16	of	of	IN
cord-304876-txaoz7oh	360	17	about	about	RB
cord-304876-txaoz7oh	360	18	20	20	CD
cord-304876-txaoz7oh	360	19	mM	mm	CD
cord-304876-txaoz7oh	360	20	,	,	,
cord-304876-txaoz7oh	360	21	without	without	IN
cord-304876-txaoz7oh	360	22	causing	cause	VBG
cord-304876-txaoz7oh	360	23	apparent	apparent	JJ
cord-304876-txaoz7oh	360	24	cell	cell	NN
cord-304876-txaoz7oh	360	25	toxicity	toxicity	NN
cord-304876-txaoz7oh	360	26	.	.	.
cord-304876-txaoz7oh	361	1	127	127	CD
cord-304876-txaoz7oh	362	1	In	in	IN
cord-304876-txaoz7oh	362	2	ferrets	ferret	NNS
cord-304876-txaoz7oh	362	3	,	,	,
cord-304876-txaoz7oh	362	4	treatment	treatment	NN
cord-304876-txaoz7oh	362	5	with	with	IN
cord-304876-txaoz7oh	362	6	2	2	CD
cord-304876-txaoz7oh	362	7	0	0	CD
cord-304876-txaoz7oh	362	8	FdG	fdg	NN
cord-304876-txaoz7oh	362	9	at	at	IN
cord-304876-txaoz7oh	362	10	20	20	CD
cord-304876-txaoz7oh	362	11	mg	mg	NNP
cord-304876-txaoz7oh	362	12	/	/	SYM
cord-304876-txaoz7oh	362	13	kg	kg	NN
cord-304876-txaoz7oh	362	14	starting	start	VBG
cord-304876-txaoz7oh	363	1	1	1	LS
cord-304876-txaoz7oh	363	2	h	h	NN
cord-304876-txaoz7oh	363	3	postinfection	postinfection	NN
cord-304876-txaoz7oh	363	4	significantly	significantly	RB
cord-304876-txaoz7oh	363	5	reduced	reduce	VBD
cord-304876-txaoz7oh	363	6	H3N2	H3N2	NNP
cord-304876-txaoz7oh	363	7	influenza	influenza	NN
cord-304876-txaoz7oh	363	8	A	a	DT
cord-304876-txaoz7oh	363	9	virus	virus	NN
cord-304876-txaoz7oh	363	10	titers	titer	NNS
cord-304876-txaoz7oh	363	11	in	in	IN
cord-304876-txaoz7oh	363	12	nasal	nasal	NN
cord-304876-txaoz7oh	363	13	washes	wash	NNS
cord-304876-txaoz7oh	363	14	,	,	,
cord-304876-txaoz7oh	363	15	associated	associate	VBN
cord-304876-txaoz7oh	363	16	with	with	IN
cord-304876-txaoz7oh	363	17	reduction	reduction	NN
cord-304876-txaoz7oh	363	18	in	in	IN
cord-304876-txaoz7oh	363	19	fever	fever	NN
cord-304876-txaoz7oh	363	20	and	and	CC
cord-304876-txaoz7oh	363	21	inflammation	inflammation	NN
cord-304876-txaoz7oh	363	22	.	.	.
cord-304876-txaoz7oh	364	1	128	128	CD
cord-304876-txaoz7oh	365	1	Although	although	IN
cord-304876-txaoz7oh	365	2	time	time	NN
cord-304876-txaoz7oh	365	3	-	-	HYPH
cord-304876-txaoz7oh	365	4	of	of	IN
cord-304876-txaoz7oh	365	5	-	-	HYPH
cord-304876-txaoz7oh	365	6	addition	addition	NN
cord-304876-txaoz7oh	365	7	experiments	experiment	NNS
cord-304876-txaoz7oh	365	8	suggested	suggest	VBD
cord-304876-txaoz7oh	365	9	that	that	IN
cord-304876-txaoz7oh	365	10	the	the	DT
cord-304876-txaoz7oh	365	11	molecule	molecule	NN
cord-304876-txaoz7oh	365	12	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	365	13	an	an	DT
cord-304876-txaoz7oh	365	14	early	early	JJ
cord-304876-txaoz7oh	365	15	step	step	NN
cord-304876-txaoz7oh	365	16	of	of	IN
cord-304876-txaoz7oh	365	17	virus	virus	NN
cord-304876-txaoz7oh	365	18	replication	replication	NN
cord-304876-txaoz7oh	365	19	,	,	,
cord-304876-txaoz7oh	365	20	more	more	RBR
cord-304876-txaoz7oh	365	21	direct	direct	JJ
cord-304876-txaoz7oh	365	22	evidence	evidence	NN
cord-304876-txaoz7oh	365	23	for	for	IN
cord-304876-txaoz7oh	365	24	the	the	DT
cord-304876-txaoz7oh	365	25	mechanism	mechanism	NN
cord-304876-txaoz7oh	365	26	of	of	IN
cord-304876-txaoz7oh	365	27	action	action	NN
cord-304876-txaoz7oh	365	28	came	come	VBD
cord-304876-txaoz7oh	365	29	from	from	IN
cord-304876-txaoz7oh	365	30	enzyme	enzyme	NN
cord-304876-txaoz7oh	365	31	inhibition	inhibition	NN
cord-304876-txaoz7oh	365	32	studies	study	NNS
cord-304876-txaoz7oh	365	33	.	.	.
cord-304876-txaoz7oh	366	1	129	129	CD
cord-304876-txaoz7oh	367	1	In	in	IN
cord-304876-txaoz7oh	367	2	cell	cell	NN
cord-304876-txaoz7oh	367	3	-	-	HYPH
cord-304876-txaoz7oh	367	4	free	free	JJ
cord-304876-txaoz7oh	367	5	transcription	transcription	NN
cord-304876-txaoz7oh	367	6	experiments	experiment	NNS
cord-304876-txaoz7oh	367	7	,	,	,
cord-304876-txaoz7oh	367	8	2	2	CD
cord-304876-txaoz7oh	367	9	0	0	CD
cord-304876-txaoz7oh	367	10	FdG	fdg	NN
cord-304876-txaoz7oh	367	11	triphosphate	triphosphate	NN
cord-304876-txaoz7oh	367	12	inhibited	inhibit	VBN
cord-304876-txaoz7oh	367	13	influenza	influenza	NN
cord-304876-txaoz7oh	367	14	A	a	DT
cord-304876-txaoz7oh	367	15	virus	virus	NN
cord-304876-txaoz7oh	367	16	RNA	rna	NN
cord-304876-txaoz7oh	367	17	polymerase	polymerase	NN
cord-304876-txaoz7oh	367	18	activity	activity	NN
cord-304876-txaoz7oh	367	19	by	by	IN
cord-304876-txaoz7oh	367	20	competing	compete	VBG
cord-304876-txaoz7oh	367	21	with	with	IN
cord-304876-txaoz7oh	367	22	natural	natural	JJ
cord-304876-txaoz7oh	367	23	GTP	GTP	NNP
cord-304876-txaoz7oh	367	24	.	.	.
cord-304876-txaoz7oh	368	1	The	the	DT
cord-304876-txaoz7oh	368	2	inhibition	inhibition	NN
cord-304876-txaoz7oh	368	3	of	of	IN
cord-304876-txaoz7oh	368	4	the	the	DT
cord-304876-txaoz7oh	368	5	enzyme	enzyme	NN
cord-304876-txaoz7oh	368	6	was	be	VBD
cord-304876-txaoz7oh	368	7	caused	cause	VBN
cord-304876-txaoz7oh	368	8	by	by	IN
cord-304876-txaoz7oh	368	9	the	the	DT
cord-304876-txaoz7oh	368	10	incorporation	incorporation	NN
cord-304876-txaoz7oh	368	11	of	of	IN
cord-304876-txaoz7oh	368	12	2	2	CD
cord-304876-txaoz7oh	368	13	0	0	CD
cord-304876-txaoz7oh	368	14	FdG	fdg	NN
cord-304876-txaoz7oh	368	15	monophosphate	monophosphate	NN
cord-304876-txaoz7oh	368	16	into	into	IN
cord-304876-txaoz7oh	368	17	the	the	DT
cord-304876-txaoz7oh	368	18	viral	viral	JJ
cord-304876-txaoz7oh	368	19	RNA	RNA	NNP
cord-304876-txaoz7oh	368	20	.	.	.
cord-304876-txaoz7oh	369	1	129	129	CD
cord-304876-txaoz7oh	369	2	More	more	RBR
cord-304876-txaoz7oh	369	3	recently	recently	RB
cord-304876-txaoz7oh	369	4	,	,	,
cord-304876-txaoz7oh	369	5	the	the	DT
cord-304876-txaoz7oh	369	6	related	related	JJ
cord-304876-txaoz7oh	369	7	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	369	8	analog	analog	NN
cord-304876-txaoz7oh	369	9	2	2	CD
cord-304876-txaoz7oh	369	10	0	0	CD
cord-304876-txaoz7oh	369	11	-deoxy-2	-deoxy-2	CD
cord-304876-txaoz7oh	369	12	0	0	CD
cord-304876-txaoz7oh	370	1	-fluoro	-fluoro	:
cord-304876-txaoz7oh	370	2	cytidine	cytidine	NNP
cord-304876-txaoz7oh	370	3	(	(	-LRB-
cord-304876-txaoz7oh	370	4	2	2	CD
cord-304876-txaoz7oh	370	5	0	0	CD
cord-304876-txaoz7oh	370	6	FdC	fdc	NN
cord-304876-txaoz7oh	370	7	)	)	-RRB-
cord-304876-txaoz7oh	370	8	was	be	VBD
cord-304876-txaoz7oh	370	9	evaluated	evaluate	VBN
cord-304876-txaoz7oh	370	10	against	against	IN
cord-304876-txaoz7oh	370	11	the	the	DT
cord-304876-txaoz7oh	370	12	highly	highly	RB
cord-304876-txaoz7oh	370	13	pathogenic	pathogenic	JJ
cord-304876-txaoz7oh	370	14	H5N1	H5N1	NNP
cord-304876-txaoz7oh	370	15	and	and	CC
cord-304876-txaoz7oh	370	16	the	the	DT
cord-304876-txaoz7oh	370	17	pandemic	pandemic	NN
cord-304876-txaoz7oh	370	18	H1N1	H1N1	NNP
cord-304876-txaoz7oh	370	19	strains	strain	NNS
cord-304876-txaoz7oh	370	20	.	.	.
cord-304876-txaoz7oh	371	1	130	130	CD
cord-304876-txaoz7oh	372	1	When	when	WRB
cord-304876-txaoz7oh	372	2	administered	administer	VBN
cord-304876-txaoz7oh	372	3	intraperitoneally	intraperitoneally	RB
cord-304876-txaoz7oh	372	4	,	,	,
cord-304876-txaoz7oh	372	5	2	2	CD
cord-304876-txaoz7oh	372	6	0	0	CD
cord-304876-txaoz7oh	372	7	FdC	fdc	NN
cord-304876-txaoz7oh	372	8	significantly	significantly	RB
cord-304876-txaoz7oh	372	9	enhanced	enhance	VBN
cord-304876-txaoz7oh	372	10	survival	survival	NN
cord-304876-txaoz7oh	372	11	of	of	IN
cord-304876-txaoz7oh	372	12	BALB	BALB	NNP
cord-304876-txaoz7oh	372	13	/	/	SYM
cord-304876-txaoz7oh	372	14	c	c	NN
cord-304876-txaoz7oh	372	15	mice	mouse	NNS
cord-304876-txaoz7oh	372	16	infected	infect	VBN
cord-304876-txaoz7oh	372	17	with	with	IN
cord-304876-txaoz7oh	372	18	a	a	DT
cord-304876-txaoz7oh	372	19	lethal	lethal	JJ
cord-304876-txaoz7oh	372	20	dose	dose	NN
cord-304876-txaoz7oh	372	21	of	of	IN
cord-304876-txaoz7oh	372	22	either	either	DT
cord-304876-txaoz7oh	372	23	H5N1	H5N1	NNP
cord-304876-txaoz7oh	372	24	or	or	CC
cord-304876-txaoz7oh	372	25	H1N1	H1N1	NNP
cord-304876-txaoz7oh	372	26	viruses	virus	NNS
cord-304876-txaoz7oh	372	27	.	.	.
cord-304876-txaoz7oh	373	1	Although	although	IN
cord-304876-txaoz7oh	373	2	these	these	DT
cord-304876-txaoz7oh	373	3	studies	study	NNS
cord-304876-txaoz7oh	373	4	show	show	VBP
cord-304876-txaoz7oh	373	5	compelling	compelling	JJ
cord-304876-txaoz7oh	373	6	evidence	evidence	NN
cord-304876-txaoz7oh	373	7	of	of	IN
cord-304876-txaoz7oh	373	8	in	in	IN
cord-304876-txaoz7oh	373	9	vivo	vivo	NN
cord-304876-txaoz7oh	373	10	efficacy	efficacy	NN
cord-304876-txaoz7oh	373	11	in	in	IN
cord-304876-txaoz7oh	373	12	preclinical	preclinical	JJ
cord-304876-txaoz7oh	373	13	species	specie	NNS
cord-304876-txaoz7oh	373	14	,	,	,
cord-304876-txaoz7oh	373	15	2	2	CD
cord-304876-txaoz7oh	373	16	0	0	CD
cord-304876-txaoz7oh	373	17	FdG	fdg	NN
cord-304876-txaoz7oh	373	18	and	and	CC
cord-304876-txaoz7oh	373	19	2	2	CD
cord-304876-txaoz7oh	373	20	0	0	CD
cord-304876-txaoz7oh	373	21	FdC	fdc	NN
cord-304876-txaoz7oh	373	22	are	be	VBP
cord-304876-txaoz7oh	373	23	not	not	RB
cord-304876-txaoz7oh	373	24	suitable	suitable	JJ
cord-304876-txaoz7oh	373	25	candidates	candidate	NNS
cord-304876-txaoz7oh	373	26	for	for	IN
cord-304876-txaoz7oh	373	27	clinical	clinical	JJ
cord-304876-txaoz7oh	373	28	development	development	NN
cord-304876-txaoz7oh	373	29	.	.	.
cord-304876-txaoz7oh	374	1	One	one	CD
cord-304876-txaoz7oh	374	2	of	of	IN
cord-304876-txaoz7oh	374	3	the	the	DT
cord-304876-txaoz7oh	374	4	main	main	JJ
cord-304876-txaoz7oh	374	5	limitations	limitation	NNS
cord-304876-txaoz7oh	374	6	of	of	IN
cord-304876-txaoz7oh	374	7	these	these	DT
cord-304876-txaoz7oh	374	8	molecules	molecule	NNS
cord-304876-txaoz7oh	374	9	is	be	VBZ
cord-304876-txaoz7oh	374	10	their	-PRON-	PRP$
cord-304876-txaoz7oh	374	11	lack	lack	NN
cord-304876-txaoz7oh	374	12	of	of	IN
cord-304876-txaoz7oh	374	13	specificity	specificity	NN
cord-304876-txaoz7oh	374	14	for	for	IN
cord-304876-txaoz7oh	374	15	influenza	influenza	NN
cord-304876-txaoz7oh	374	16	virus	virus	NN
cord-304876-txaoz7oh	374	17	polymerase	polymerase	NN
cord-304876-txaoz7oh	374	18	.	.	.
cord-304876-txaoz7oh	375	1	The	the	DT
cord-304876-txaoz7oh	375	2	ability	ability	NN
cord-304876-txaoz7oh	375	3	of	of	IN
cord-304876-txaoz7oh	375	4	a	a	DT
cord-304876-txaoz7oh	375	5	nucleotide	nucleotide	NN
cord-304876-txaoz7oh	375	6	to	to	TO
cord-304876-txaoz7oh	375	7	inhibit	inhibit	VB
cord-304876-txaoz7oh	375	8	distant	distant	JJ
cord-304876-txaoz7oh	375	9	molecular	molecular	JJ
cord-304876-txaoz7oh	375	10	targets	target	NNS
cord-304876-txaoz7oh	375	11	is	be	VBZ
cord-304876-txaoz7oh	375	12	not	not	RB
cord-304876-txaoz7oh	375	13	detrimental	detrimental	JJ
cord-304876-txaoz7oh	375	14	per	per	FW
cord-304876-txaoz7oh	375	15	se	se	FW
cord-304876-txaoz7oh	375	16	.	.	.
cord-304876-txaoz7oh	376	1	As	as	IN
cord-304876-txaoz7oh	376	2	such	such	JJ
cord-304876-txaoz7oh	376	3	,	,	,
cord-304876-txaoz7oh	376	4	2	2	CD
cord-304876-txaoz7oh	376	5	0	0	CD
cord-304876-txaoz7oh	376	6	-deoxy-2	-deoxy-2	ADD
cord-304876-txaoz7oh	376	7	0	0	CD
cord-304876-txaoz7oh	376	8	-fluoro	-fluoro	NNS
cord-304876-txaoz7oh	376	9	nucleotides	nucleotide	NNS
cord-304876-txaoz7oh	376	10	and	and	CC
cord-304876-txaoz7oh	376	11	their	-PRON-	PRP$
cord-304876-txaoz7oh	376	12	derivatives	derivative	NNS
cord-304876-txaoz7oh	376	13	interact	interact	VBP
cord-304876-txaoz7oh	376	14	with	with	IN
cord-304876-txaoz7oh	376	15	the	the	DT
cord-304876-txaoz7oh	376	16	RNA	RNA	NNP
cord-304876-txaoz7oh	376	17	polymerase	polymerase	NN
cord-304876-txaoz7oh	376	18	of	of	IN
cord-304876-txaoz7oh	376	19	HCV	HCV	NNP
cord-304876-txaoz7oh	376	20	.	.	.
cord-304876-txaoz7oh	377	1	[	[	-LRB-
cord-304876-txaoz7oh	377	2	131	131	CD
cord-304876-txaoz7oh	377	3	]	]	-RRB-
cord-304876-txaoz7oh	377	4	[	[	-LRB-
cord-304876-txaoz7oh	377	5	132	132	CD
cord-304876-txaoz7oh	377	6	]	]	-RRB-
cord-304876-txaoz7oh	378	1	[	[	-LRB-
cord-304876-txaoz7oh	378	2	133	133	CD
cord-304876-txaoz7oh	378	3	]	]	-RRB-
cord-304876-txaoz7oh	378	4	[	[	-LRB-
cord-304876-txaoz7oh	378	5	134	134	CD
cord-304876-txaoz7oh	378	6	]	]	-RRB-
cord-304876-txaoz7oh	379	1	But	but	CC
cord-304876-txaoz7oh	379	2	the	the	DT
cord-304876-txaoz7oh	379	3	substitution	substitution	NN
cord-304876-txaoz7oh	379	4	of	of	IN
cord-304876-txaoz7oh	379	5	the	the	DT
cord-304876-txaoz7oh	379	6	2	2	CD
cord-304876-txaoz7oh	379	7	0	0	CD
cord-304876-txaoz7oh	379	8	-hydroxy	-hydroxy	:
cord-304876-txaoz7oh	379	9	by	by	IN
cord-304876-txaoz7oh	379	10	a	a	DT
cord-304876-txaoz7oh	379	11	fluoro	fluoro	NNP
cord-304876-txaoz7oh	379	12	group	group	NN
cord-304876-txaoz7oh	379	13	also	also	RB
cord-304876-txaoz7oh	379	14	makes	make	VBZ
cord-304876-txaoz7oh	379	15	the	the	DT
cord-304876-txaoz7oh	379	16	resulting	result	VBG
cord-304876-txaoz7oh	379	17	nucleotides	nucleotide	NNS
cord-304876-txaoz7oh	379	18	broad	broad	JJ
cord-304876-txaoz7oh	379	19	substrates	substrate	NNS
cord-304876-txaoz7oh	379	20	for	for	IN
cord-304876-txaoz7oh	379	21	viral	viral	JJ
cord-304876-txaoz7oh	379	22	135	135	CD
cord-304876-txaoz7oh	379	23	and	and	CC
cord-304876-txaoz7oh	379	24	human	human	JJ
cord-304876-txaoz7oh	379	25	136	136	CD
cord-304876-txaoz7oh	379	26	DNA	dna	NN
cord-304876-txaoz7oh	379	27	polymerases	polymerase	NNS
cord-304876-txaoz7oh	379	28	.	.	.
cord-304876-txaoz7oh	380	1	In	in	IN
cord-304876-txaoz7oh	380	2	the	the	DT
cord-304876-txaoz7oh	380	3	latter	latter	JJ
cord-304876-txaoz7oh	380	4	study	study	NN
cord-304876-txaoz7oh	380	5	,	,	,
cord-304876-txaoz7oh	380	6	the	the	DT
cord-304876-txaoz7oh	380	7	authors	author	NNS
cord-304876-txaoz7oh	380	8	have	have	VBP
cord-304876-txaoz7oh	380	9	shown	show	VBN
cord-304876-txaoz7oh	380	10	that	that	IN
cord-304876-txaoz7oh	380	11	the	the	DT
cord-304876-txaoz7oh	380	12	monophosphate	monophosphate	NN
cord-304876-txaoz7oh	380	13	form	form	NN
cord-304876-txaoz7oh	380	14	of	of	IN
cord-304876-txaoz7oh	380	15	both	both	DT
cord-304876-txaoz7oh	380	16	2	2	CD
cord-304876-txaoz7oh	380	17	0	0	CD
cord-304876-txaoz7oh	380	18	FdC	fdc	NN
cord-304876-txaoz7oh	380	19	and	and	CC
cord-304876-txaoz7oh	380	20	2	2	CD
cord-304876-txaoz7oh	380	21	0	0	CD
cord-304876-txaoz7oh	380	22	FdG	fdg	NN
cord-304876-txaoz7oh	380	23	can	can	MD
cord-304876-txaoz7oh	380	24	be	be	VB
cord-304876-txaoz7oh	380	25	incorporated	incorporate	VBN
cord-304876-txaoz7oh	380	26	into	into	IN
cord-304876-txaoz7oh	380	27	DNA	DNA	NNP
cord-304876-txaoz7oh	380	28	by	by	IN
cord-304876-txaoz7oh	380	29	human	human	JJ
cord-304876-txaoz7oh	380	30	DNA	dna	NN
cord-304876-txaoz7oh	380	31	polymerase	polymerase	NN
cord-304876-txaoz7oh	380	32	alpha	alpha	NN
cord-304876-txaoz7oh	380	33	and	and	CC
cord-304876-txaoz7oh	380	34	gamma	gamma	NN
cord-304876-txaoz7oh	380	35	.	.	.
cord-304876-txaoz7oh	381	1	This	this	DT
cord-304876-txaoz7oh	381	2	might	may	MD
cord-304876-txaoz7oh	381	3	explain	explain	VB
cord-304876-txaoz7oh	381	4	the	the	DT
cord-304876-txaoz7oh	381	5	changes	change	NNS
cord-304876-txaoz7oh	381	6	in	in	IN
cord-304876-txaoz7oh	381	7	cell	cell	NN
cord-304876-txaoz7oh	381	8	cycle	cycle	NN
cord-304876-txaoz7oh	381	9	distribution	distribution	NN
cord-304876-txaoz7oh	381	10	and	and	CC
cord-304876-txaoz7oh	381	11	cytostatic	cytostatic	JJ
cord-304876-txaoz7oh	381	12	effect	effect	NN
cord-304876-txaoz7oh	381	13	caused	cause	VBN
cord-304876-txaoz7oh	381	14	by	by	IN
cord-304876-txaoz7oh	381	15	prolonged	prolong	VBN
cord-304876-txaoz7oh	381	16	in	in	IN
cord-304876-txaoz7oh	381	17	vitro	vitro	FW
cord-304876-txaoz7oh	381	18	incubation	incubation	NN
cord-304876-txaoz7oh	381	19	with	with	IN
cord-304876-txaoz7oh	381	20	2	2	CD
cord-304876-txaoz7oh	381	21	0	0	CD
cord-304876-txaoz7oh	381	22	FdC.	FdC.	NNP
cord-304876-txaoz7oh	381	23	133	133	CD
cord-304876-txaoz7oh	382	1	Paradoxically	paradoxically	RB
cord-304876-txaoz7oh	382	2	,	,	,
cord-304876-txaoz7oh	382	3	the	the	DT
cord-304876-txaoz7oh	382	4	same	same	JJ
cord-304876-txaoz7oh	382	5	molecule	molecule	NN
cord-304876-txaoz7oh	382	6	was	be	VBD
cord-304876-txaoz7oh	382	7	well	well	RB
cord-304876-txaoz7oh	382	8	tolerated	tolerate	VBN
cord-304876-txaoz7oh	382	9	when	when	WRB
cord-304876-txaoz7oh	382	10	administered	administer	VBN
cord-304876-txaoz7oh	382	11	intravenously	intravenously	RB
cord-304876-txaoz7oh	382	12	to	to	IN
cord-304876-txaoz7oh	382	13	rats	rat	NNS
cord-304876-txaoz7oh	382	14	and	and	CC
cord-304876-txaoz7oh	382	15	woodchucks	woodchuck	NNS
cord-304876-txaoz7oh	382	16	for	for	IN
cord-304876-txaoz7oh	382	17	up	up	IN
cord-304876-txaoz7oh	382	18	to	to	TO
cord-304876-txaoz7oh	382	19	90	90	CD
cord-304876-txaoz7oh	382	20	days	day	NNS
cord-304876-txaoz7oh	382	21	.	.	.
cord-304876-txaoz7oh	383	1	137	137	CD
cord-304876-txaoz7oh	384	1	One	one	CD
cord-304876-txaoz7oh	384	2	hypothesis	hypothesis	NN
cord-304876-txaoz7oh	384	3	for	for	IN
cord-304876-txaoz7oh	384	4	this	this	DT
cord-304876-txaoz7oh	384	5	discrepancy	discrepancy	NN
cord-304876-txaoz7oh	384	6	is	be	VBZ
cord-304876-txaoz7oh	384	7	that	that	IN
cord-304876-txaoz7oh	384	8	a	a	DT
cord-304876-txaoz7oh	384	9	low	low	JJ
cord-304876-txaoz7oh	384	10	organ	organ	NN
cord-304876-txaoz7oh	384	11	exposure	exposure	NN
cord-304876-txaoz7oh	384	12	of	of	IN
cord-304876-txaoz7oh	384	13	the	the	DT
cord-304876-txaoz7oh	384	14	phosphorylated	phosphorylated	JJ
cord-304876-txaoz7oh	384	15	metabolite(s	metabolite(s	NN
cord-304876-txaoz7oh	384	16	)	)	-RRB-
cord-304876-txaoz7oh	384	17	of	of	IN
cord-304876-txaoz7oh	384	18	2	2	CD
cord-304876-txaoz7oh	384	19	0	0	CD
cord-304876-txaoz7oh	384	20	FdC	fdc	NN
cord-304876-txaoz7oh	384	21	could	could	MD
cord-304876-txaoz7oh	384	22	limit	limit	VB
cord-304876-txaoz7oh	384	23	the	the	DT
cord-304876-txaoz7oh	384	24	toxic	toxic	JJ
cord-304876-txaoz7oh	384	25	effect	effect	NN
cord-304876-txaoz7oh	384	26	on	on	IN
cord-304876-txaoz7oh	384	27	dividing	divide	VBG
cord-304876-txaoz7oh	384	28	cells	cell	NNS
cord-304876-txaoz7oh	384	29	in	in	IN
cord-304876-txaoz7oh	384	30	these	these	DT
cord-304876-txaoz7oh	384	31	animals	animal	NNS
cord-304876-txaoz7oh	384	32	.	.	.
cord-304876-txaoz7oh	385	1	The	the	DT
cord-304876-txaoz7oh	385	2	antiviral	antiviral	JJ
cord-304876-txaoz7oh	385	3	6-fluoro-3-hydroxy-2-pyrazinecarboxamide	6-fluoro-3-hydroxy-2-pyrazinecarboxamide	CD
cord-304876-txaoz7oh	385	4	(	(	-LRB-
cord-304876-txaoz7oh	385	5	T-705	T-705	NNS
cord-304876-txaoz7oh	385	6	,	,	,
cord-304876-txaoz7oh	385	7	favipiravir	favipiravir	NNP
cord-304876-txaoz7oh	385	8	,	,	,
cord-304876-txaoz7oh	385	9	AVIGAN	AVIGAN	NNP
cord-304876-txaoz7oh	385	10	)	)	-RRB-
cord-304876-txaoz7oh	385	11	has	have	VBZ
cord-304876-txaoz7oh	385	12	been	be	VBN
cord-304876-txaoz7oh	385	13	approved	approve	VBN
cord-304876-txaoz7oh	385	14	in	in	IN
cord-304876-txaoz7oh	385	15	Japan	Japan	NNP
cord-304876-txaoz7oh	385	16	for	for	IN
cord-304876-txaoz7oh	385	17	the	the	DT
cord-304876-txaoz7oh	385	18	treatment	treatment	NN
cord-304876-txaoz7oh	385	19	of	of	IN
cord-304876-txaoz7oh	385	20	influenza	influenza	NN
cord-304876-txaoz7oh	385	21	infection	infection	NN
cord-304876-txaoz7oh	385	22	since	since	IN
cord-304876-txaoz7oh	385	23	2014	2014	CD
cord-304876-txaoz7oh	385	24	.	.	.
cord-304876-txaoz7oh	386	1	T-705	T-705	NNP
cord-304876-txaoz7oh	386	2	is	be	VBZ
cord-304876-txaoz7oh	386	3	a	a	DT
cord-304876-txaoz7oh	386	4	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	386	5	precursor	precursor	NN
cord-304876-txaoz7oh	386	6	inhibiting	inhibit	VBG
cord-304876-txaoz7oh	386	7	influenza	influenza	NN
cord-304876-txaoz7oh	386	8	virus	virus	NN
cord-304876-txaoz7oh	386	9	with	with	IN
cord-304876-txaoz7oh	386	10	broad	broad	JJ
cord-304876-txaoz7oh	386	11	-	-	HYPH
cord-304876-txaoz7oh	386	12	strain	strain	NN
cord-304876-txaoz7oh	386	13	coverage	coverage	NN
cord-304876-txaoz7oh	386	14	137,139	137,139	CD
cord-304876-txaoz7oh	386	15	(	(	-LRB-
cord-304876-txaoz7oh	386	16	Figure	figure	NN
cord-304876-txaoz7oh	386	17	5	5	CD
cord-304876-txaoz7oh	386	18	)	)	-RRB-
cord-304876-txaoz7oh	386	19	.	.	.
cord-304876-txaoz7oh	387	1	It	-PRON-	PRP
cord-304876-txaoz7oh	387	2	is	be	VBZ
cord-304876-txaoz7oh	387	3	often	often	RB
cord-304876-txaoz7oh	387	4	proposed	propose	VBN
cord-304876-txaoz7oh	387	5	that	that	IN
cord-304876-txaoz7oh	387	6	T-705	t-705	NN
cord-304876-txaoz7oh	387	7	exerts	exert	VBZ
cord-304876-txaoz7oh	387	8	its	-PRON-	PRP$
cord-304876-txaoz7oh	387	9	antiviral	antiviral	JJ
cord-304876-txaoz7oh	387	10	activity	activity	NN
cord-304876-txaoz7oh	387	11	through	through	IN
cord-304876-txaoz7oh	387	12	its	-PRON-	PRP$
cord-304876-txaoz7oh	387	13	NTP	NTP	NNP
cord-304876-txaoz7oh	387	14	form	form	NN
cord-304876-txaoz7oh	387	15	(	(	-LRB-
cord-304876-txaoz7oh	387	16	T-705	t-705	NN
cord-304876-txaoz7oh	387	17	RTP	RTP	NNP
cord-304876-txaoz7oh	387	18	)	)	-RRB-
cord-304876-txaoz7oh	387	19	by	by	IN
cord-304876-txaoz7oh	387	20	directly	directly	RB
cord-304876-txaoz7oh	387	21	inhibiting	inhibit	VBG
cord-304876-txaoz7oh	387	22	the	the	DT
cord-304876-txaoz7oh	387	23	RdRp	RdRp	NNP
cord-304876-txaoz7oh	387	24	activity	activity	NN
cord-304876-txaoz7oh	387	25	of	of	IN
cord-304876-txaoz7oh	387	26	influenza	influenza	NN
cord-304876-txaoz7oh	387	27	A	a	DT
cord-304876-txaoz7oh	387	28	virus	virus	NN
cord-304876-txaoz7oh	387	29	polymerase	polymerase	NN
cord-304876-txaoz7oh	387	30	,	,	,
cord-304876-txaoz7oh	387	31	140	140	CD
cord-304876-txaoz7oh	387	32	but	but	CC
cord-304876-txaoz7oh	387	33	the	the	DT
cord-304876-txaoz7oh	387	34	exact	exact	JJ
cord-304876-txaoz7oh	387	35	mode	mode	NN
cord-304876-txaoz7oh	387	36	of	of	IN
cord-304876-txaoz7oh	387	37	action	action	NN
cord-304876-txaoz7oh	387	38	and	and	CC
cord-304876-txaoz7oh	387	39	precise	precise	JJ
cord-304876-txaoz7oh	387	40	molecular	molecular	JJ
cord-304876-txaoz7oh	387	41	interaction	interaction	NN
cord-304876-txaoz7oh	387	42	between	between	IN
cord-304876-txaoz7oh	387	43	the	the	DT
cord-304876-txaoz7oh	387	44	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	387	45	and	and	CC
cord-304876-txaoz7oh	387	46	the	the	DT
cord-304876-txaoz7oh	387	47	viral	viral	JJ
cord-304876-txaoz7oh	387	48	polymerase	polymerase	NN
cord-304876-txaoz7oh	387	49	has	have	VBZ
cord-304876-txaoz7oh	387	50	been	be	VBN
cord-304876-txaoz7oh	387	51	elusive	elusive	JJ
cord-304876-txaoz7oh	387	52	.	.	.
cord-304876-txaoz7oh	388	1	In	in	IN
cord-304876-txaoz7oh	388	2	vitro	vitro	FW
cord-304876-txaoz7oh	388	3	,	,	,
cord-304876-txaoz7oh	388	4	T-705	t-705	NN
cord-304876-txaoz7oh	388	5	is	be	VBZ
cord-304876-txaoz7oh	388	6	efficiently	efficiently	RB
cord-304876-txaoz7oh	388	7	converted	convert	VBN
cord-304876-txaoz7oh	388	8	to	to	IN
cord-304876-txaoz7oh	388	9	its	-PRON-	PRP$
cord-304876-txaoz7oh	388	10	ribofuranosyl	ribofuranosyl	NN
cord-304876-txaoz7oh	388	11	5	5	CD
cord-304876-txaoz7oh	388	12	0	0	CD
cord-304876-txaoz7oh	388	13	-triphosphate	-triphosphate	NN
cord-304876-txaoz7oh	388	14	(	(	-LRB-
cord-304876-txaoz7oh	388	15	T-705	T-705	VBZ
cord-304876-txaoz7oh	388	16	RTP	RTP	NNP
cord-304876-txaoz7oh	388	17	)	)	-RRB-
cord-304876-txaoz7oh	388	18	form	form	NN
cord-304876-txaoz7oh	388	19	by	by	IN
cord-304876-txaoz7oh	388	20	cellular	cellular	JJ
cord-304876-txaoz7oh	388	21	enzymes	enzyme	NNS
cord-304876-txaoz7oh	388	22	.	.	.
cord-304876-txaoz7oh	389	1	141	141	CD
cord-304876-txaoz7oh	389	2	Treatment	treatment	NN
cord-304876-txaoz7oh	389	3	of	of	IN
cord-304876-txaoz7oh	389	4	influenza	influenza	NN
cord-304876-txaoz7oh	389	5	A	a	DT
cord-304876-txaoz7oh	389	6	virus	virus	NN
cord-304876-txaoz7oh	389	7	-	-	HYPH
cord-304876-txaoz7oh	389	8	infected	infect	VBN
cord-304876-txaoz7oh	389	9	cells	cell	NNS
cord-304876-txaoz7oh	389	10	with	with	IN
cord-304876-txaoz7oh	389	11	T-705	t-705	NN
cord-304876-txaoz7oh	389	12	results	result	NNS
cord-304876-txaoz7oh	389	13	in	in	IN
cord-304876-txaoz7oh	389	14	a	a	DT
cord-304876-txaoz7oh	389	15	significant	significant	JJ
cord-304876-txaoz7oh	389	16	increase	increase	NN
cord-304876-txaoz7oh	389	17	of	of	IN
cord-304876-txaoz7oh	389	18	lethal	lethal	JJ
cord-304876-txaoz7oh	389	19	mutations	mutation	NNS
cord-304876-txaoz7oh	389	20	within	within	IN
cord-304876-txaoz7oh	389	21	the	the	DT
cord-304876-txaoz7oh	389	22	viral	viral	JJ
cord-304876-txaoz7oh	389	23	genome	genome	NN
cord-304876-txaoz7oh	389	24	,	,	,
cord-304876-txaoz7oh	389	25	a	a	DT
cord-304876-txaoz7oh	389	26	phenomenon	phenomenon	NN
cord-304876-txaoz7oh	389	27	also	also	RB
cord-304876-txaoz7oh	389	28	described	describe	VBN
cord-304876-txaoz7oh	389	29	as	as	IN
cord-304876-txaoz7oh	389	30	error	error	NN
cord-304876-txaoz7oh	389	31	catastrophe	catastrophe	NN
cord-304876-txaoz7oh	389	32	.	.	.
cord-304876-txaoz7oh	390	1	142	142	CD
cord-304876-txaoz7oh	391	1	The	the	DT
cord-304876-txaoz7oh	391	2	lethal	lethal	JJ
cord-304876-txaoz7oh	391	3	mutagenesis	mutagenesis	NN
cord-304876-txaoz7oh	391	4	hypothesis	hypothesis	NN
cord-304876-txaoz7oh	391	5	is	be	VBZ
cord-304876-txaoz7oh	391	6	supported	support	VBN
cord-304876-txaoz7oh	391	7	by	by	IN
cord-304876-txaoz7oh	391	8	enzymatic	enzymatic	JJ
cord-304876-txaoz7oh	391	9	assays	assay	NNS
cord-304876-txaoz7oh	391	10	showing	show	VBG
cord-304876-txaoz7oh	391	11	that	that	IN
cord-304876-txaoz7oh	391	12	T-705	T-705	VBZ
cord-304876-txaoz7oh	391	13	RTP	RTP	NNP
cord-304876-txaoz7oh	391	14	is	be	VBZ
cord-304876-txaoz7oh	391	15	efficiently	efficiently	RB
cord-304876-txaoz7oh	391	16	recognized	recognize	VBN
cord-304876-txaoz7oh	391	17	by	by	IN
cord-304876-txaoz7oh	392	1	influenza	influenza	NN
cord-304876-txaoz7oh	392	2	A	a	DT
cord-304876-txaoz7oh	392	3	virus	virus	NN
cord-304876-txaoz7oh	392	4	polymerase	polymerase	NN
cord-304876-txaoz7oh	392	5	both	both	CC
cord-304876-txaoz7oh	392	6	as	as	IN
cord-304876-txaoz7oh	392	7	a	a	DT
cord-304876-txaoz7oh	392	8	guanosine	guanosine	NN
cord-304876-txaoz7oh	392	9	and	and	CC
cord-304876-txaoz7oh	392	10	an	an	DT
cord-304876-txaoz7oh	392	11	adenosine	adenosine	NN
cord-304876-txaoz7oh	392	12	analog	analog	NN
cord-304876-txaoz7oh	392	13	.	.	.
cord-304876-txaoz7oh	393	1	143	143	CD
cord-304876-txaoz7oh	394	1	In	in	IN
cord-304876-txaoz7oh	394	2	addition	addition	NN
cord-304876-txaoz7oh	394	3	,	,	,
cord-304876-txaoz7oh	394	4	single	single	JJ
cord-304876-txaoz7oh	394	5	events	event	NNS
cord-304876-txaoz7oh	394	6	of	of	IN
cord-304876-txaoz7oh	394	7	T-705	t-705	NN
cord-304876-txaoz7oh	394	8	RMP	RMP	NNP
cord-304876-txaoz7oh	394	9	incorporation	incorporation	NN
cord-304876-txaoz7oh	394	10	into	into	IN
cord-304876-txaoz7oh	394	11	RNA	RNA	NNP
cord-304876-txaoz7oh	394	12	by	by	IN
cord-304876-txaoz7oh	394	13	influenza	influenza	NN
cord-304876-txaoz7oh	394	14	A	a	DT
cord-304876-txaoz7oh	394	15	virus	virus	NN
cord-304876-txaoz7oh	394	16	polymerase	polymerase	NN
cord-304876-txaoz7oh	394	17	delayed	delay	VBN
cord-304876-txaoz7oh	394	18	but	but	CC
cord-304876-txaoz7oh	394	19	did	do	VBD
cord-304876-txaoz7oh	394	20	not	not	RB
cord-304876-txaoz7oh	394	21	block	block	VB
cord-304876-txaoz7oh	394	22	the	the	DT
cord-304876-txaoz7oh	394	23	extension	extension	NN
cord-304876-txaoz7oh	394	24	of	of	IN
cord-304876-txaoz7oh	394	25	the	the	DT
cord-304876-txaoz7oh	394	26	RNA	RNA	NNP
cord-304876-txaoz7oh	394	27	primer	primer	NN
cord-304876-txaoz7oh	394	28	strand	strand	NN
cord-304876-txaoz7oh	394	29	.	.	.
cord-304876-txaoz7oh	395	1	The	the	DT
cord-304876-txaoz7oh	395	2	antiviral	antiviral	JJ
cord-304876-txaoz7oh	395	3	potency	potency	NN
cord-304876-txaoz7oh	395	4	of	of	IN
cord-304876-txaoz7oh	395	5	T-705	t-705	NN
cord-304876-txaoz7oh	395	6	covers	cover	VBZ
cord-304876-txaoz7oh	395	7	other	other	JJ
cord-304876-txaoz7oh	395	8	virus	virus	NN
cord-304876-txaoz7oh	395	9	families	family	NNS
cord-304876-txaoz7oh	395	10	well	well	RB
cord-304876-txaoz7oh	395	11	beyond	beyond	IN
cord-304876-txaoz7oh	395	12	orthomyxoviruses	orthomyxovirus	NNS
cord-304876-txaoz7oh	395	13	.	.	.
cord-304876-txaoz7oh	396	1	T-705	T-705	NNP
cord-304876-txaoz7oh	396	2	has	have	VBZ
cord-304876-txaoz7oh	396	3	been	be	VBN
cord-304876-txaoz7oh	396	4	shown	show	VBN
cord-304876-txaoz7oh	396	5	to	to	TO
cord-304876-txaoz7oh	396	6	inhibit	inhibit	VB
cord-304876-txaoz7oh	396	7	a	a	DT
cord-304876-txaoz7oh	396	8	number	number	NN
cord-304876-txaoz7oh	396	9	of	of	IN
cord-304876-txaoz7oh	396	10	diverse	diverse	JJ
cord-304876-txaoz7oh	396	11	RNA	RNA	NNP
cord-304876-txaoz7oh	396	12	viruses	virus	NNS
cord-304876-txaoz7oh	396	13	unrelated	unrelated	JJ
cord-304876-txaoz7oh	396	14	to	to	IN
cord-304876-txaoz7oh	396	15	influenza	influenza	NN
cord-304876-txaoz7oh	396	16	,	,	,
cord-304876-txaoz7oh	396	17	including	include	VBG
cord-304876-txaoz7oh	396	18	representatives	representative	NNS
cord-304876-txaoz7oh	396	19	of	of	IN
cord-304876-txaoz7oh	396	20	noroviruses	noroviruses	NNP
cord-304876-txaoz7oh	396	21	,	,	,
cord-304876-txaoz7oh	396	22	bunyaviruses	bunyaviruses	NNP
cord-304876-txaoz7oh	396	23	,	,	,
cord-304876-txaoz7oh	396	24	arenaviruses	arenaviruses	NNP
cord-304876-txaoz7oh	396	25	,	,	,
cord-304876-txaoz7oh	396	26	flaviviruses	flavivirus	NNS
cord-304876-txaoz7oh	396	27	,	,	,
cord-304876-txaoz7oh	396	28	and	and	CC
cord-304876-txaoz7oh	396	29	filoviruses	filovirus	NNS
cord-304876-txaoz7oh	396	30	.	.	.
cord-304876-txaoz7oh	397	1	[	[	-LRB-
cord-304876-txaoz7oh	397	2	144	144	CD
cord-304876-txaoz7oh	397	3	]	]	-RRB-
cord-304876-txaoz7oh	397	4	[	[	-LRB-
cord-304876-txaoz7oh	397	5	145	145	CD
cord-304876-txaoz7oh	397	6	]	]	-RRB-
cord-304876-txaoz7oh	397	7	[	[	-LRB-
cord-304876-txaoz7oh	397	8	146	146	CD
cord-304876-txaoz7oh	397	9	]	]	-RRB-
cord-304876-txaoz7oh	397	10	[	[	-LRB-
cord-304876-txaoz7oh	397	11	147	147	CD
cord-304876-txaoz7oh	397	12	]	]	-RRB-
cord-304876-txaoz7oh	397	13	[	[	-LRB-
cord-304876-txaoz7oh	397	14	148	148	CD
cord-304876-txaoz7oh	397	15	]	]	-RRB-
cord-304876-txaoz7oh	397	16	[	[	-LRB-
cord-304876-txaoz7oh	397	17	149	149	CD
cord-304876-txaoz7oh	397	18	]	]	-RRB-
cord-304876-txaoz7oh	397	19	[	[	-LRB-
cord-304876-txaoz7oh	397	20	150	150	CD
cord-304876-txaoz7oh	397	21	]	]	-RRB-
cord-304876-txaoz7oh	398	1	[	[	-LRB-
cord-304876-txaoz7oh	398	2	151	151	CD
cord-304876-txaoz7oh	398	3	]	]	-RRB-
cord-304876-txaoz7oh	399	1	[	[	-LRB-
cord-304876-txaoz7oh	399	2	152	152	CD
cord-304876-txaoz7oh	399	3	]	]	-RRB-
cord-304876-txaoz7oh	400	1	It	-PRON-	PRP
cord-304876-txaoz7oh	400	2	is	be	VBZ
cord-304876-txaoz7oh	400	3	interesting	interesting	JJ
cord-304876-txaoz7oh	400	4	to	to	TO
cord-304876-txaoz7oh	400	5	point	point	VB
cord-304876-txaoz7oh	400	6	out	out	RP
cord-304876-txaoz7oh	400	7	that	that	IN
cord-304876-txaoz7oh	400	8	the	the	DT
cord-304876-txaoz7oh	400	9	mutagenic	mutagenic	JJ
cord-304876-txaoz7oh	400	10	effect	effect	NN
cord-304876-txaoz7oh	400	11	of	of	IN
cord-304876-txaoz7oh	400	12	T-705	t-705	NN
cord-304876-txaoz7oh	400	13	has	have	VBZ
cord-304876-txaoz7oh	400	14	also	also	RB
cord-304876-txaoz7oh	400	15	been	be	VBN
cord-304876-txaoz7oh	400	16	documented	document	VBN
cord-304876-txaoz7oh	400	17	for	for	IN
cord-304876-txaoz7oh	400	18	HCV	HCV	NNP
cord-304876-txaoz7oh	400	19	.	.	.
cord-304876-txaoz7oh	401	1	153	153	CD
cord-304876-txaoz7oh	402	1	At	at	IN
cord-304876-txaoz7oh	402	2	the	the	DT
cord-304876-txaoz7oh	402	3	biochemical	biochemical	JJ
cord-304876-txaoz7oh	402	4	level	level	NN
cord-304876-txaoz7oh	402	5	,	,	,
cord-304876-txaoz7oh	402	6	we	-PRON-	PRP
cord-304876-txaoz7oh	402	7	showed	show	VBD
cord-304876-txaoz7oh	402	8	that	that	IN
cord-304876-txaoz7oh	402	9	T-705	t-705	NN
cord-304876-txaoz7oh	402	10	is	be	VBZ
cord-304876-txaoz7oh	402	11	recognized	recognize	VBN
cord-304876-txaoz7oh	402	12	as	as	IN
cord-304876-txaoz7oh	402	13	substrate	substrate	NN
cord-304876-txaoz7oh	402	14	for	for	IN
cord-304876-txaoz7oh	402	15	RNA	RNA	NNP
cord-304876-txaoz7oh	402	16	synthesis	synthesis	NN
cord-304876-txaoz7oh	402	17	not	not	RB
cord-304876-txaoz7oh	402	18	only	only	RB
cord-304876-txaoz7oh	402	19	by	by	IN
cord-304876-txaoz7oh	402	20	viral	viral	JJ
cord-304876-txaoz7oh	402	21	polymerases	polymerase	NNS
cord-304876-txaoz7oh	402	22	,	,	,
cord-304876-txaoz7oh	402	23	but	but	CC
cord-304876-txaoz7oh	402	24	also	also	RB
cord-304876-txaoz7oh	402	25	by	by	IN
cord-304876-txaoz7oh	402	26	human	human	JJ
cord-304876-txaoz7oh	402	27	mitochondrial	mitochondrial	NN
cord-304876-txaoz7oh	402	28	RNA	RNA	NNP
cord-304876-txaoz7oh	402	29	polymerase	polymerase	NN
cord-304876-txaoz7oh	402	30	.	.	.
cord-304876-txaoz7oh	403	1	154	154	CD
cord-304876-txaoz7oh	403	2	,	,	,
cord-304876-txaoz7oh	403	3	155	155	CD
cord-304876-txaoz7oh	404	1	This	this	DT
cord-304876-txaoz7oh	404	2	host	host	NN
cord-304876-txaoz7oh	404	3	-	-	HYPH
cord-304876-txaoz7oh	404	4	based	base	VBN
cord-304876-txaoz7oh	404	5	interaction	interaction	NN
cord-304876-txaoz7oh	404	6	did	do	VBD
cord-304876-txaoz7oh	404	7	not	not	RB
cord-304876-txaoz7oh	404	8	result	result	VB
cord-304876-txaoz7oh	404	9	in	in	IN
cord-304876-txaoz7oh	404	10	any	any	DT
cord-304876-txaoz7oh	404	11	measurable	measurable	JJ
cord-304876-txaoz7oh	404	12	in	in	IN
cord-304876-txaoz7oh	404	13	vitro	vitro	FW
cord-304876-txaoz7oh	404	14	mitochondrial	mitochondrial	JJ
cord-304876-txaoz7oh	404	15	toxicity	toxicity	NN
cord-304876-txaoz7oh	404	16	,	,	,
cord-304876-txaoz7oh	404	17	but	but	CC
cord-304876-txaoz7oh	404	18	it	-PRON-	PRP
cord-304876-txaoz7oh	404	19	raised	raise	VBD
cord-304876-txaoz7oh	404	20	more	more	JJR
cord-304876-txaoz7oh	404	21	questions	question	NNS
cord-304876-txaoz7oh	404	22	about	about	IN
cord-304876-txaoz7oh	404	23	the	the	DT
cord-304876-txaoz7oh	404	24	mechanism	mechanism	NN
cord-304876-txaoz7oh	404	25	of	of	IN
cord-304876-txaoz7oh	404	26	action	action	NN
cord-304876-txaoz7oh	404	27	of	of	IN
cord-304876-txaoz7oh	404	28	the	the	DT
cord-304876-txaoz7oh	404	29	compound	compound	NN
cord-304876-txaoz7oh	404	30	.	.	.
cord-304876-txaoz7oh	405	1	Recently	recently	RB
cord-304876-txaoz7oh	405	2	,	,	,
cord-304876-txaoz7oh	405	3	the	the	DT
cord-304876-txaoz7oh	405	4	possibility	possibility	NN
cord-304876-txaoz7oh	405	5	that	that	IN
cord-304876-txaoz7oh	405	6	T-705	t-705	NN
cord-304876-txaoz7oh	405	7	exerts	exert	VBZ
cord-304876-txaoz7oh	405	8	its	-PRON-	PRP$
cord-304876-txaoz7oh	405	9	main	main	JJ
cord-304876-txaoz7oh	405	10	antiviral	antiviral	JJ
cord-304876-txaoz7oh	405	11	effect	effect	NN
cord-304876-txaoz7oh	405	12	without	without	IN
cord-304876-txaoz7oh	405	13	converting	convert	VBG
cord-304876-txaoz7oh	405	14	to	to	IN
cord-304876-txaoz7oh	405	15	its	-PRON-	PRP$
cord-304876-txaoz7oh	405	16	triphosphate	triphosphate	NN
cord-304876-txaoz7oh	405	17	form	form	NN
cord-304876-txaoz7oh	405	18	came	come	VBD
cord-304876-txaoz7oh	405	19	from	from	IN
cord-304876-txaoz7oh	405	20	the	the	DT
cord-304876-txaoz7oh	405	21	observation	observation	NN
cord-304876-txaoz7oh	405	22	that	that	WDT
cord-304876-txaoz7oh	405	23	T-705	T-705	VBZ
cord-304876-txaoz7oh	405	24	ribonucleoside	ribonucleoside	NN
cord-304876-txaoz7oh	405	25	is	be	VBZ
cord-304876-txaoz7oh	405	26	chemically	chemically	RB
cord-304876-txaoz7oh	405	27	unstable	unstable	JJ
cord-304876-txaoz7oh	405	28	under	under	IN
cord-304876-txaoz7oh	405	29	biological	biological	JJ
cord-304876-txaoz7oh	405	30	conditions	condition	NNS
cord-304876-txaoz7oh	405	31	.	.	.
cord-304876-txaoz7oh	406	1	156	156	CD
cord-304876-txaoz7oh	407	1	Even	even	RB
cord-304876-txaoz7oh	407	2	though	though	IN
cord-304876-txaoz7oh	407	3	T-705	t-705	NN
cord-304876-txaoz7oh	407	4	does	do	VBZ
cord-304876-txaoz7oh	407	5	not	not	RB
cord-304876-txaoz7oh	407	6	seem	seem	VB
cord-304876-txaoz7oh	407	7	to	to	TO
cord-304876-txaoz7oh	407	8	potently	potently	RB
cord-304876-txaoz7oh	407	9	inhibit	inhibit	VB
cord-304876-txaoz7oh	407	10	the	the	DT
cord-304876-txaoz7oh	407	11	human	human	JJ
cord-304876-txaoz7oh	407	12	IMPDH	IMPDH	NNP
cord-304876-txaoz7oh	407	13	enzyme	enzyme	NN
cord-304876-txaoz7oh	407	14	,	,	,
cord-304876-txaoz7oh	407	15	157	157	CD
cord-304876-txaoz7oh	407	16	its	-PRON-	PRP$
cord-304876-txaoz7oh	407	17	very	very	RB
cord-304876-txaoz7oh	407	18	broad	broad	JJ
cord-304876-txaoz7oh	407	19	antiviral	antiviral	JJ
cord-304876-txaoz7oh	407	20	spectrum	spectrum	NN
cord-304876-txaoz7oh	407	21	and	and	CC
cord-304876-txaoz7oh	407	22	its	-PRON-	PRP$
cord-304876-txaoz7oh	407	23	capacity	capacity	NN
cord-304876-txaoz7oh	407	24	to	to	TO
cord-304876-txaoz7oh	407	25	induce	induce	VB
cord-304876-txaoz7oh	407	26	lethal	lethal	JJ
cord-304876-txaoz7oh	407	27	mutagenesis	mutagenesis	NN
cord-304876-txaoz7oh	407	28	are	be	VBP
cord-304876-txaoz7oh	407	29	somewhat	somewhat	RB
cord-304876-txaoz7oh	407	30	reminiscent	reminiscent	JJ
cord-304876-txaoz7oh	407	31	of	of	IN
cord-304876-txaoz7oh	407	32	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	407	33	,	,	,
cord-304876-txaoz7oh	407	34	another	another	DT
cord-304876-txaoz7oh	407	35	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	407	36	that	that	WDT
cord-304876-txaoz7oh	407	37	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	407	38	HCV	HCV	NNP
cord-304876-txaoz7oh	407	39	replication	replication	NN
cord-304876-txaoz7oh	407	40	through	through	IN
cord-304876-txaoz7oh	407	41	host	host	NN
cord-304876-txaoz7oh	407	42	-	-	HYPH
cord-304876-txaoz7oh	407	43	based	base	VBN
cord-304876-txaoz7oh	407	44	mechanisms	mechanism	NNS
cord-304876-txaoz7oh	407	45	.	.	.
cord-304876-txaoz7oh	408	1	Therefore	therefore	RB
cord-304876-txaoz7oh	408	2	,	,	,
cord-304876-txaoz7oh	408	3	the	the	DT
cord-304876-txaoz7oh	408	4	possibility	possibility	NN
cord-304876-txaoz7oh	408	5	that	that	IN
cord-304876-txaoz7oh	408	6	T-705	t-705	NN
cord-304876-txaoz7oh	408	7	exerts	exert	VBZ
cord-304876-txaoz7oh	408	8	its	-PRON-	PRP$
cord-304876-txaoz7oh	408	9	inhibition	inhibition	NN
cord-304876-txaoz7oh	408	10	through	through	IN
cord-304876-txaoz7oh	408	11	interactions	interaction	NNS
cord-304876-txaoz7oh	408	12	with	with	IN
cord-304876-txaoz7oh	408	13	host	host	NN
cord-304876-txaoz7oh	408	14	proteins	protein	NNS
cord-304876-txaoz7oh	408	15	can	can	MD
cord-304876-txaoz7oh	408	16	not	not	RB
cord-304876-txaoz7oh	408	17	be	be	VB
cord-304876-txaoz7oh	408	18	ruled	rule	VBN
cord-304876-txaoz7oh	408	19	out	out	RP
cord-304876-txaoz7oh	408	20	and	and	CC
cord-304876-txaoz7oh	408	21	remains	remain	VBZ
cord-304876-txaoz7oh	408	22	to	to	TO
cord-304876-txaoz7oh	408	23	be	be	VB
cord-304876-txaoz7oh	408	24	further	further	RB
cord-304876-txaoz7oh	408	25	explored	explore	VBN
cord-304876-txaoz7oh	408	26	.	.	.
cord-304876-txaoz7oh	409	1	Considering	consider	VBG
cord-304876-txaoz7oh	409	2	its	-PRON-	PRP$
cord-304876-txaoz7oh	409	3	similarities	similarity	NNS
cord-304876-txaoz7oh	409	4	with	with	IN
cord-304876-txaoz7oh	409	5	ribavirin	ribavirin	NNS
cord-304876-txaoz7oh	409	6	in	in	IN
cord-304876-txaoz7oh	409	7	terms	term	NNS
cord-304876-txaoz7oh	409	8	of	of	IN
cord-304876-txaoz7oh	409	9	antiviral	antiviral	JJ
cord-304876-txaoz7oh	409	10	spectrum	spectrum	NN
cord-304876-txaoz7oh	409	11	and	and	CC
cord-304876-txaoz7oh	409	12	mode	mode	NN
cord-304876-txaoz7oh	409	13	of	of	IN
cord-304876-txaoz7oh	409	14	action	action	NN
cord-304876-txaoz7oh	409	15	,	,	,
cord-304876-txaoz7oh	409	16	it	-PRON-	PRP
cord-304876-txaoz7oh	409	17	will	will	MD
cord-304876-txaoz7oh	409	18	be	be	VB
cord-304876-txaoz7oh	409	19	interesting	interesting	JJ
cord-304876-txaoz7oh	409	20	to	to	TO
cord-304876-txaoz7oh	409	21	see	see	VB
cord-304876-txaoz7oh	410	1	if	if	IN
cord-304876-txaoz7oh	410	2	T-705	T-705	NNS
cord-304876-txaoz7oh	410	3	becomes	become	VBZ
cord-304876-txaoz7oh	410	4	more	more	RBR
cord-304876-txaoz7oh	410	5	widely	widely	RB
cord-304876-txaoz7oh	410	6	used	use	VBN
cord-304876-txaoz7oh	410	7	in	in	IN
cord-304876-txaoz7oh	410	8	patients	patient	NNS
cord-304876-txaoz7oh	410	9	suffering	suffer	VBG
cord-304876-txaoz7oh	410	10	from	from	IN
cord-304876-txaoz7oh	410	11	respiratory	respiratory	JJ
cord-304876-txaoz7oh	410	12	viral	viral	JJ
cord-304876-txaoz7oh	410	13	infections	infection	NNS
cord-304876-txaoz7oh	410	14	,	,	,
cord-304876-txaoz7oh	410	15	or	or	CC
cord-304876-txaoz7oh	410	16	if	if	IN
cord-304876-txaoz7oh	410	17	it	-PRON-	PRP
cord-304876-txaoz7oh	410	18	will	will	MD
cord-304876-txaoz7oh	410	19	remain	remain	VB
cord-304876-txaoz7oh	410	20	limited	limited	JJ
cord-304876-txaoz7oh	410	21	to	to	IN
cord-304876-txaoz7oh	410	22	stockpiling	stockpile	VBG
cord-304876-txaoz7oh	410	23	for	for	IN
cord-304876-txaoz7oh	410	24	potential	potential	JJ
cord-304876-txaoz7oh	410	25	influenza	influenza	NN
cord-304876-txaoz7oh	410	26	pandemic	pandemic	NN
cord-304876-txaoz7oh	410	27	in	in	IN
cord-304876-txaoz7oh	410	28	Japan	Japan	NNP
cord-304876-txaoz7oh	410	29	.	.	.
cord-304876-txaoz7oh	411	1	The	the	DT
cord-304876-txaoz7oh	411	2	discovery	discovery	NN
cord-304876-txaoz7oh	411	3	of	of	IN
cord-304876-txaoz7oh	411	4	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	411	5	,	,	,
cord-304876-txaoz7oh	411	6	the	the	DT
cord-304876-txaoz7oh	411	7	parent	parent	NN
cord-304876-txaoz7oh	411	8	molecule	molecule	NN
cord-304876-txaoz7oh	411	9	of	of	IN
cord-304876-txaoz7oh	411	10	the	the	DT
cord-304876-txaoz7oh	411	11	prodrug	prodrug	NN
cord-304876-txaoz7oh	411	12	ALS-8176	ALS-8176	NNPS
cord-304876-txaoz7oh	411	13	(	(	-LRB-
cord-304876-txaoz7oh	411	14	lumicitabine	lumicitabine	NNP
cord-304876-txaoz7oh	411	15	)	)	-RRB-
cord-304876-txaoz7oh	411	16	,	,	,
cord-304876-txaoz7oh	411	17	was	be	VBD
cord-304876-txaoz7oh	411	18	the	the	DT
cord-304876-txaoz7oh	411	19	result	result	NN
cord-304876-txaoz7oh	411	20	of	of	IN
cord-304876-txaoz7oh	411	21	a	a	DT
cord-304876-txaoz7oh	411	22	screening	screening	NN
cord-304876-txaoz7oh	411	23	campaign	campaign	NN
cord-304876-txaoz7oh	411	24	using	use	VBG
cord-304876-txaoz7oh	411	25	a	a	DT
cord-304876-txaoz7oh	411	26	focused	focused	JJ
cord-304876-txaoz7oh	411	27	library	library	NN
cord-304876-txaoz7oh	411	28	of	of	IN
cord-304876-txaoz7oh	411	29	structurally	structurally	RB
cord-304876-txaoz7oh	411	30	diverse	diverse	JJ
cord-304876-txaoz7oh	411	31	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	411	32	and	and	CC
cord-304876-txaoz7oh	411	33	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	411	34	analogs	analog	NNS
cord-304876-txaoz7oh	411	35	tested	test	VBN
cord-304876-txaoz7oh	411	36	against	against	IN
cord-304876-txaoz7oh	411	37	RSV	RSV	NNP
cord-304876-txaoz7oh	411	38	in	in	IN
cord-304876-txaoz7oh	411	39	an	an	DT
cord-304876-txaoz7oh	411	40	in	in	FW
cord-304876-txaoz7oh	411	41	vitro	vitro	FW
cord-304876-txaoz7oh	411	42	infectious	infectious	JJ
cord-304876-txaoz7oh	411	43	assay	assay	NN
cord-304876-txaoz7oh	411	44	.	.	.
cord-304876-txaoz7oh	412	1	158	158	CD
cord-304876-txaoz7oh	413	1	The	the	DT
cord-304876-txaoz7oh	413	2	main	main	JJ
cord-304876-txaoz7oh	413	3	scaffold	scaffold	NN
cord-304876-txaoz7oh	413	4	identified	identify	VBN
cord-304876-txaoz7oh	413	5	from	from	IN
cord-304876-txaoz7oh	413	6	this	this	DT
cord-304876-txaoz7oh	413	7	screen	screen	NN
cord-304876-txaoz7oh	413	8	was	be	VBD
cord-304876-txaoz7oh	413	9	2	2	CD
cord-304876-txaoz7oh	413	10	0	0	CD
cord-304876-txaoz7oh	413	11	difluoro-4	difluoro-4	XX
cord-304876-txaoz7oh	413	12	0	0	CD
cord-304876-txaoz7oh	413	13	azido	azido	NNP
cord-304876-txaoz7oh	413	14	-	-	HYPH
cord-304876-txaoz7oh	413	15	cytidine	cytidine	NNP
cord-304876-txaoz7oh	413	16	.	.	.
cord-304876-txaoz7oh	414	1	Further	further	JJ
cord-304876-txaoz7oh	414	2	modifications	modification	NNS
cord-304876-txaoz7oh	414	3	at	at	IN
cord-304876-txaoz7oh	414	4	the	the	DT
cord-304876-txaoz7oh	414	5	2	2	CD
cord-304876-txaoz7oh	414	6	0	0	CD
cord-304876-txaoz7oh	414	7	-and	-and	CD
cord-304876-txaoz7oh	414	8	4	4	CD
cord-304876-txaoz7oh	414	9	0	0	CD
cord-304876-txaoz7oh	414	10	-positions	-position	NNS
cord-304876-txaoz7oh	414	11	to	to	TO
cord-304876-txaoz7oh	414	12	improve	improve	VB
cord-304876-txaoz7oh	414	13	anti	anti	JJ
cord-304876-txaoz7oh	414	14	-	-	JJ
cord-304876-txaoz7oh	414	15	RSV	rsv	JJ
cord-304876-txaoz7oh	414	16	potency	potency	NN
cord-304876-txaoz7oh	414	17	and	and	CC
cord-304876-txaoz7oh	414	18	selectivity	selectivity	NN
cord-304876-txaoz7oh	414	19	,	,	,
cord-304876-txaoz7oh	414	20	led	lead	VBD
cord-304876-txaoz7oh	414	21	to	to	IN
cord-304876-txaoz7oh	414	22	the	the	DT
cord-304876-txaoz7oh	414	23	identification	identification	NN
cord-304876-txaoz7oh	414	24	of	of	IN
cord-304876-txaoz7oh	414	25	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	414	26	(	(	-LRB-
cord-304876-txaoz7oh	414	27	2	2	CD
cord-304876-txaoz7oh	414	28	0	0	CD
cord-304876-txaoz7oh	414	29	fluoro-4	fluoro-4	NN
cord-304876-txaoz7oh	414	30	0	0	CD
cord-304876-txaoz7oh	414	31	chloromethyl	chloromethyl	NN
cord-304876-txaoz7oh	414	32	-	-	HYPH
cord-304876-txaoz7oh	414	33	cytidine	cytidine	NN
cord-304876-txaoz7oh	414	34	)	)	-RRB-
cord-304876-txaoz7oh	415	1	(	(	-LRB-
cord-304876-txaoz7oh	415	2	Figure	figure	NN
cord-304876-txaoz7oh	415	3	5	5	CD
cord-304876-txaoz7oh	415	4	)	)	-RRB-
cord-304876-txaoz7oh	415	5	.	.	.
cord-304876-txaoz7oh	416	1	In	in	IN
cord-304876-txaoz7oh	416	2	vitro	vitro	FW
cord-304876-txaoz7oh	416	3	,	,	,
cord-304876-txaoz7oh	416	4	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	416	5	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	416	6	a	a	DT
cord-304876-txaoz7oh	416	7	broad	broad	JJ
cord-304876-txaoz7oh	416	8	panel	panel	NN
cord-304876-txaoz7oh	416	9	of	of	IN
cord-304876-txaoz7oh	416	10	RSV	RSV	NNP
cord-304876-txaoz7oh	416	11	A	A	NNP
cord-304876-txaoz7oh	416	12	and	and	CC
cord-304876-txaoz7oh	416	13	B	b	NN
cord-304876-txaoz7oh	416	14	subtypes	subtype	NNS
cord-304876-txaoz7oh	416	15	,	,	,
cord-304876-txaoz7oh	416	16	as	as	RB
cord-304876-txaoz7oh	416	17	well	well	RB
cord-304876-txaoz7oh	416	18	as	as	IN
cord-304876-txaoz7oh	416	19	related	related	JJ
cord-304876-txaoz7oh	416	20	pneumo-	pneumo-	NN
cord-304876-txaoz7oh	416	21	,	,	,
cord-304876-txaoz7oh	416	22	paramyxo-	paramyxo-	NN
cord-304876-txaoz7oh	416	23	,	,	,
cord-304876-txaoz7oh	416	24	and	and	CC
cord-304876-txaoz7oh	416	25	rhabdoviruses	rhabdovirus	NNS
cord-304876-txaoz7oh	416	26	.	.	.
cord-304876-txaoz7oh	417	1	159	159	CD
cord-304876-txaoz7oh	418	1	In	in	IN
cord-304876-txaoz7oh	418	2	particular	particular	JJ
cord-304876-txaoz7oh	418	3	,	,	,
cord-304876-txaoz7oh	418	4	we	-PRON-	PRP
cord-304876-txaoz7oh	418	5	recently	recently	RB
cord-304876-txaoz7oh	418	6	reported	report	VBD
cord-304876-txaoz7oh	418	7	that	that	IN
cord-304876-txaoz7oh	418	8	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	418	9	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	418	10	RSV	RSV	NNP
cord-304876-txaoz7oh	418	11	and	and	CC
cord-304876-txaoz7oh	418	12	HMPV	HMPV	NNP
cord-304876-txaoz7oh	418	13	with	with	IN
cord-304876-txaoz7oh	418	14	similar	similar	JJ
cord-304876-txaoz7oh	418	15	in	in	IN
cord-304876-txaoz7oh	418	16	vitro	vitro	FW
cord-304876-txaoz7oh	418	17	potency	potency	NN
cord-304876-txaoz7oh	418	18	.	.	.
cord-304876-txaoz7oh	419	1	160	160	CD
cord-304876-txaoz7oh	420	1	The	the	DT
cord-304876-txaoz7oh	420	2	molecular	molecular	JJ
cord-304876-txaoz7oh	420	3	target	target	NN
cord-304876-txaoz7oh	420	4	of	of	IN
cord-304876-txaoz7oh	420	5	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	420	6	was	be	VBD
cord-304876-txaoz7oh	420	7	determined	determine	VBN
cord-304876-txaoz7oh	420	8	by	by	IN
cord-304876-txaoz7oh	420	9	two	two	CD
cord-304876-txaoz7oh	420	10	independent	independent	JJ
cord-304876-txaoz7oh	420	11	methods	method	NNS
cord-304876-txaoz7oh	420	12	.	.	.
cord-304876-txaoz7oh	421	1	The	the	DT
cord-304876-txaoz7oh	421	2	polymerization	polymerization	NN
cord-304876-txaoz7oh	421	3	function	function	NN
cord-304876-txaoz7oh	421	4	of	of	IN
cord-304876-txaoz7oh	421	5	the	the	DT
cord-304876-txaoz7oh	421	6	RSV	RSV	NNP
cord-304876-txaoz7oh	421	7	L	L	NNP
cord-304876-txaoz7oh	421	8	protein	protein	NN
cord-304876-txaoz7oh	421	9	was	be	VBD
cord-304876-txaoz7oh	421	10	identified	identify	VBN
cord-304876-txaoz7oh	421	11	as	as	IN
cord-304876-txaoz7oh	421	12	the	the	DT
cord-304876-txaoz7oh	421	13	target	target	NN
cord-304876-txaoz7oh	421	14	of	of	IN
cord-304876-txaoz7oh	421	15	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	421	16	inhibition	inhibition	NN
cord-304876-txaoz7oh	421	17	,	,	,
cord-304876-txaoz7oh	421	18	first	first	RB
cord-304876-txaoz7oh	421	19	,	,	,
cord-304876-txaoz7oh	421	20	by	by	IN
cord-304876-txaoz7oh	421	21	selecting	select	VBG
cord-304876-txaoz7oh	421	22	and	and	CC
cord-304876-txaoz7oh	421	23	characterizing	characterize	VBG
cord-304876-txaoz7oh	421	24	drug	drug	NN
cord-304876-txaoz7oh	421	25	resistanceassociated	resistanceassociated	JJ
cord-304876-txaoz7oh	421	26	mutations	mutation	NNS
cord-304876-txaoz7oh	421	27	located	locate	VBN
cord-304876-txaoz7oh	421	28	in	in	IN
cord-304876-txaoz7oh	421	29	the	the	DT
cord-304876-txaoz7oh	421	30	L	L	NNP
cord-304876-txaoz7oh	421	31	gene	gene	NN
cord-304876-txaoz7oh	421	32	.	.	.
cord-304876-txaoz7oh	422	1	When	when	WRB
cord-304876-txaoz7oh	422	2	introduced	introduce	VBN
cord-304876-txaoz7oh	422	3	into	into	IN
cord-304876-txaoz7oh	422	4	a	a	DT
cord-304876-txaoz7oh	422	5	wild	wild	JJ
cord-304876-txaoz7oh	422	6	-	-	HYPH
cord-304876-txaoz7oh	422	7	type	type	NN
cord-304876-txaoz7oh	422	8	RSV	RSV	NNP
cord-304876-txaoz7oh	422	9	genome	genome	NN
cord-304876-txaoz7oh	422	10	,	,	,
cord-304876-txaoz7oh	422	11	four	four	CD
cord-304876-txaoz7oh	422	12	amino	amino	NN
cord-304876-txaoz7oh	422	13	acid	acid	NN
cord-304876-txaoz7oh	422	14	mutations	mutation	NNS
cord-304876-txaoz7oh	423	1	(	(	-LRB-
cord-304876-txaoz7oh	423	2	M628L	M628L	NNS
cord-304876-txaoz7oh	423	3	,	,	,
cord-304876-txaoz7oh	423	4	A789V	A789V	NNP
cord-304876-txaoz7oh	423	5	,	,	,
cord-304876-txaoz7oh	423	6	L795I	L795I	NNP
cord-304876-txaoz7oh	423	7	,	,	,
cord-304876-txaoz7oh	423	8	and	and	CC
cord-304876-txaoz7oh	423	9	I796V	i796v	NN
cord-304876-txaoz7oh	423	10	)	)	-RRB-
cord-304876-txaoz7oh	423	11	were	be	VBD
cord-304876-txaoz7oh	423	12	phenotypically	phenotypically	RB
cord-304876-txaoz7oh	423	13	associated	associate	VBN
cord-304876-txaoz7oh	423	14	with	with	IN
cord-304876-txaoz7oh	423	15	resistance	resistance	NN
cord-304876-txaoz7oh	423	16	to	to	IN
cord-304876-txaoz7oh	423	17	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	423	18	.	.	.
cord-304876-txaoz7oh	424	1	159	159	CD
cord-304876-txaoz7oh	424	2	Enzymatic	enzymatic	JJ
cord-304876-txaoz7oh	424	3	assays	assay	NNS
cord-304876-txaoz7oh	424	4	using	use	VBG
cord-304876-txaoz7oh	424	5	purified	purify	VBN
cord-304876-txaoz7oh	424	6	recombinant	recombinant	JJ
cord-304876-txaoz7oh	424	7	RSV	RSV	NNP
cord-304876-txaoz7oh	424	8	polymerase	polymerase	NN
cord-304876-txaoz7oh	424	9	were	be	VBD
cord-304876-txaoz7oh	424	10	critical	critical	JJ
cord-304876-txaoz7oh	424	11	to	to	TO
cord-304876-txaoz7oh	424	12	validate	validate	VB
cord-304876-txaoz7oh	424	13	the	the	DT
cord-304876-txaoz7oh	424	14	mode	mode	NN
cord-304876-txaoz7oh	424	15	of	of	IN
cord-304876-txaoz7oh	424	16	action	action	NN
cord-304876-txaoz7oh	424	17	of	of	IN
cord-304876-txaoz7oh	424	18	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	424	19	.	.	.
cord-304876-txaoz7oh	425	1	In	in	IN
cord-304876-txaoz7oh	425	2	these	these	DT
cord-304876-txaoz7oh	425	3	assays	assay	NNS
cord-304876-txaoz7oh	425	4	,	,	,
cord-304876-txaoz7oh	425	5	the	the	DT
cord-304876-txaoz7oh	425	6	5	5	CD
cord-304876-txaoz7oh	425	7	0	0	CD
cord-304876-txaoz7oh	425	8	-triphosphate	-triphosphate	NN
cord-304876-txaoz7oh	425	9	form	form	NN
cord-304876-txaoz7oh	425	10	of	of	IN
cord-304876-txaoz7oh	425	11	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	425	12	(	(	-LRB-
cord-304876-txaoz7oh	425	13	ALS-8112-TP	ALS-8112-TP	NNP
cord-304876-txaoz7oh	425	14	)	)	-RRB-
cord-304876-txaoz7oh	425	15	caused	cause	VBD
cord-304876-txaoz7oh	425	16	immediate	immediate	JJ
cord-304876-txaoz7oh	425	17	chain	chain	NN
cord-304876-txaoz7oh	425	18	termination	termination	NN
cord-304876-txaoz7oh	425	19	of	of	IN
cord-304876-txaoz7oh	425	20	RNA	RNA	NNP
cord-304876-txaoz7oh	425	21	synthesis	synthesis	NN
cord-304876-txaoz7oh	425	22	and	and	CC
cord-304876-txaoz7oh	425	23	inhibition	inhibition	NN
cord-304876-txaoz7oh	425	24	of	of	IN
cord-304876-txaoz7oh	425	25	the	the	DT
cord-304876-txaoz7oh	425	26	viral	viral	JJ
cord-304876-txaoz7oh	425	27	polymerization	polymerization	NN
cord-304876-txaoz7oh	425	28	activity	activity	NN
cord-304876-txaoz7oh	425	29	.	.	.
cord-304876-txaoz7oh	426	1	This	this	DT
cord-304876-txaoz7oh	426	2	inhibitory	inhibitory	JJ
cord-304876-txaoz7oh	426	3	effect	effect	NN
cord-304876-txaoz7oh	426	4	was	be	VBD
cord-304876-txaoz7oh	426	5	specific	specific	JJ
cord-304876-txaoz7oh	426	6	to	to	IN
cord-304876-txaoz7oh	426	7	RSV	RSV	NNP
cord-304876-txaoz7oh	426	8	polymerase	polymerase	NN
cord-304876-txaoz7oh	426	9	,	,	,
cord-304876-txaoz7oh	426	10	since	since	IN
cord-304876-txaoz7oh	426	11	ALS-8112-TP	ALS-8112-TP	NNP
cord-304876-txaoz7oh	426	12	did	do	VBD
cord-304876-txaoz7oh	426	13	not	not	RB
cord-304876-txaoz7oh	426	14	inhibit	inhibit	VB
cord-304876-txaoz7oh	426	15	polymerases	polymerase	NNS
cord-304876-txaoz7oh	426	16	from	from	IN
cord-304876-txaoz7oh	426	17	host	host	NN
cord-304876-txaoz7oh	426	18	or	or	CC
cord-304876-txaoz7oh	426	19	viruses	virus	NNS
cord-304876-txaoz7oh	426	20	unrelated	unrelated	JJ
cord-304876-txaoz7oh	426	21	to	to	IN
cord-304876-txaoz7oh	426	22	RSV	RSV	NNP
cord-304876-txaoz7oh	426	23	such	such	JJ
cord-304876-txaoz7oh	426	24	as	as	IN
cord-304876-txaoz7oh	426	25	HCV	HCV	NNP
cord-304876-txaoz7oh	426	26	.	.	.
cord-304876-txaoz7oh	427	1	The	the	DT
cord-304876-txaoz7oh	427	2	lack	lack	NN
cord-304876-txaoz7oh	427	3	of	of	IN
cord-304876-txaoz7oh	427	4	inhibition	inhibition	NN
cord-304876-txaoz7oh	427	5	against	against	IN
cord-304876-txaoz7oh	427	6	HCV	HCV	NNP
cord-304876-txaoz7oh	427	7	was	be	VBD
cord-304876-txaoz7oh	427	8	rationalized	rationalize	VBN
cord-304876-txaoz7oh	427	9	by	by	IN
cord-304876-txaoz7oh	427	10	molecular	molecular	JJ
cord-304876-txaoz7oh	427	11	modeling	modeling	NN
cord-304876-txaoz7oh	427	12	,	,	,
cord-304876-txaoz7oh	427	13	predicting	predict	VBG
cord-304876-txaoz7oh	427	14	steric	steric	JJ
cord-304876-txaoz7oh	427	15	clashing	clashing	NN
cord-304876-txaoz7oh	427	16	of	of	IN
cord-304876-txaoz7oh	427	17	ALS-8112-TP	als-8112-tp	NN
cord-304876-txaoz7oh	427	18	inside	inside	IN
cord-304876-txaoz7oh	427	19	the	the	DT
cord-304876-txaoz7oh	427	20	active	active	JJ
cord-304876-txaoz7oh	427	21	site	site	NN
cord-304876-txaoz7oh	427	22	of	of	IN
cord-304876-txaoz7oh	427	23	HCV	HCV	NNP
cord-304876-txaoz7oh	427	24	polymerase	polymerase	NN
cord-304876-txaoz7oh	427	25	.	.	.
cord-304876-txaoz7oh	428	1	Because	because	IN
cord-304876-txaoz7oh	428	2	of	of	IN
cord-304876-txaoz7oh	428	3	the	the	DT
cord-304876-txaoz7oh	428	4	low	low	JJ
cord-304876-txaoz7oh	428	5	oral	oral	JJ
cord-304876-txaoz7oh	428	6	bioavailability	bioavailability	NN
cord-304876-txaoz7oh	428	7	of	of	IN
cord-304876-txaoz7oh	428	8	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	428	9	,	,	,
cord-304876-txaoz7oh	428	10	a	a	DT
cord-304876-txaoz7oh	428	11	series	series	NN
cord-304876-txaoz7oh	428	12	of	of	IN
cord-304876-txaoz7oh	428	13	2	2	CD
cord-304876-txaoz7oh	428	14	0	0	CD
cord-304876-txaoz7oh	428	15	,	,	,
cord-304876-txaoz7oh	428	16	3	3	CD
cord-304876-txaoz7oh	428	17	0	0	CD
cord-304876-txaoz7oh	429	1	-diester	-diester	NFP
cord-304876-txaoz7oh	429	2	prodrugs	prodrug	NNS
cord-304876-txaoz7oh	429	3	was	be	VBD
cord-304876-txaoz7oh	429	4	evaluated	evaluate	VBN
cord-304876-txaoz7oh	429	5	for	for	IN
cord-304876-txaoz7oh	429	6	improved	improve	VBN
cord-304876-txaoz7oh	429	7	pharmacokinetic	pharmacokinetic	JJ
cord-304876-txaoz7oh	429	8	properties	property	NNS
cord-304876-txaoz7oh	429	9	.	.	.
cord-304876-txaoz7oh	430	1	One	one	CD
cord-304876-txaoz7oh	430	2	prodrug	prodrug	NN
cord-304876-txaoz7oh	430	3	,	,	,
cord-304876-txaoz7oh	430	4	ALS-8176	ALS-8176	NNPS
cord-304876-txaoz7oh	430	5	,	,	,
cord-304876-txaoz7oh	430	6	formed	form	VBD
cord-304876-txaoz7oh	430	7	high	high	JJ
cord-304876-txaoz7oh	430	8	levels	level	NNS
cord-304876-txaoz7oh	430	9	of	of	IN
cord-304876-txaoz7oh	430	10	monophosphate	monophosphate	NN
cord-304876-txaoz7oh	430	11	and	and	CC
cord-304876-txaoz7oh	430	12	triphosphate	triphosphate	NN
cord-304876-txaoz7oh	430	13	in	in	IN
cord-304876-txaoz7oh	430	14	the	the	DT
cord-304876-txaoz7oh	430	15	lungs	lung	NNS
cord-304876-txaoz7oh	430	16	when	when	WRB
cord-304876-txaoz7oh	430	17	administered	administer	VBN
cord-304876-txaoz7oh	430	18	orally	orally	RB
cord-304876-txaoz7oh	430	19	to	to	IN
cord-304876-txaoz7oh	430	20	nonhuman	nonhuman	NN
cord-304876-txaoz7oh	430	21	primates	primate	NNS
cord-304876-txaoz7oh	430	22	.	.	.
cord-304876-txaoz7oh	431	1	Because	because	IN
cord-304876-txaoz7oh	431	2	of	of	IN
cord-304876-txaoz7oh	431	3	its	-PRON-	PRP$
cord-304876-txaoz7oh	431	4	high	high	JJ
cord-304876-txaoz7oh	431	5	oral	oral	JJ
cord-304876-txaoz7oh	431	6	bioavailability	bioavailability	NN
cord-304876-txaoz7oh	431	7	,	,	,
cord-304876-txaoz7oh	431	8	ALS-8176	ALS-8176	NNPS
cord-304876-txaoz7oh	431	9	was	be	VBD
cord-304876-txaoz7oh	431	10	evaluated	evaluate	VBN
cord-304876-txaoz7oh	431	11	for	for	IN
cord-304876-txaoz7oh	431	12	in	in	IN
cord-304876-txaoz7oh	431	13	vivo	vivo	NN
cord-304876-txaoz7oh	431	14	efficacy	efficacy	NN
cord-304876-txaoz7oh	431	15	in	in	IN
cord-304876-txaoz7oh	431	16	African	african	JJ
cord-304876-txaoz7oh	431	17	green	green	JJ
cord-304876-txaoz7oh	431	18	monkeys	monkey	NNS
cord-304876-txaoz7oh	431	19	infected	infect	VBN
cord-304876-txaoz7oh	431	20	with	with	IN
cord-304876-txaoz7oh	431	21	RSV	RSV	NNP
cord-304876-txaoz7oh	431	22	.	.	.
cord-304876-txaoz7oh	432	1	At	at	IN
cord-304876-txaoz7oh	432	2	the	the	DT
cord-304876-txaoz7oh	432	3	end	end	NN
cord-304876-txaoz7oh	432	4	of	of	IN
cord-304876-txaoz7oh	432	5	treatment	treatment	NN
cord-304876-txaoz7oh	432	6	,	,	,
cord-304876-txaoz7oh	432	7	RSV	RSV	NNP
cord-304876-txaoz7oh	432	8	RNA	RNA	NNP
cord-304876-txaoz7oh	432	9	was	be	VBD
cord-304876-txaoz7oh	432	10	undetectable	undetectable	JJ
cord-304876-txaoz7oh	432	11	in	in	IN
cord-304876-txaoz7oh	432	12	bronchoalveolar	bronchoalveolar	JJ
cord-304876-txaoz7oh	432	13	lavage	lavage	NN
cord-304876-txaoz7oh	432	14	samples	sample	NNS
cord-304876-txaoz7oh	432	15	from	from	IN
cord-304876-txaoz7oh	432	16	all	all	DT
cord-304876-txaoz7oh	432	17	four	four	CD
cord-304876-txaoz7oh	432	18	ALS-8176-treated	als-8176-treate	VBN
cord-304876-txaoz7oh	432	19	animals	animal	NNS
cord-304876-txaoz7oh	432	20	.	.	.
cord-304876-txaoz7oh	433	1	159	159	CD
cord-304876-txaoz7oh	434	1	Subsequently	subsequently	RB
cord-304876-txaoz7oh	434	2	,	,	,
cord-304876-txaoz7oh	434	3	a	a	DT
cord-304876-txaoz7oh	434	4	randomized	randomized	JJ
cord-304876-txaoz7oh	434	5	,	,	,
cord-304876-txaoz7oh	434	6	double	double	JJ
cord-304876-txaoz7oh	434	7	-	-	HYPH
cord-304876-txaoz7oh	434	8	blind	blind	JJ
cord-304876-txaoz7oh	434	9	,	,	,
cord-304876-txaoz7oh	434	10	clinical	clinical	JJ
cord-304876-txaoz7oh	434	11	trial	trial	NN
cord-304876-txaoz7oh	434	12	evaluated	evaluate	VBD
cord-304876-txaoz7oh	434	13	ALS-8176	ALS-8176	NNP
cord-304876-txaoz7oh	434	14	given	give	VBN
cord-304876-txaoz7oh	434	15	for	for	IN
cord-304876-txaoz7oh	434	16	5	5	CD
cord-304876-txaoz7oh	434	17	days	day	NNS
cord-304876-txaoz7oh	434	18	to	to	IN
cord-304876-txaoz7oh	434	19	healthy	healthy	JJ
cord-304876-txaoz7oh	434	20	adults	adult	NNS
cord-304876-txaoz7oh	434	21	inoculated	inoculate	VBN
cord-304876-txaoz7oh	434	22	with	with	IN
cord-304876-txaoz7oh	434	23	RSV	RSV	NNP
cord-304876-txaoz7oh	434	24	.	.	.
cord-304876-txaoz7oh	435	1	161	161	CD
cord-304876-txaoz7oh	436	1	The	the	DT
cord-304876-txaoz7oh	436	2	reduction	reduction	NN
cord-304876-txaoz7oh	436	3	in	in	IN
cord-304876-txaoz7oh	436	4	viral	viral	JJ
cord-304876-txaoz7oh	436	5	load	load	NN
cord-304876-txaoz7oh	436	6	in	in	IN
cord-304876-txaoz7oh	436	7	nasal	nasal	NN
cord-304876-txaoz7oh	436	8	washes	wash	NNS
cord-304876-txaoz7oh	436	9	associated	associate	VBN
cord-304876-txaoz7oh	436	10	with	with	IN
cord-304876-txaoz7oh	436	11	ALS-8176	als-8176	JJ
cord-304876-txaoz7oh	436	12	treatment	treatment	NN
cord-304876-txaoz7oh	436	13	varied	vary	VBN
cord-304876-txaoz7oh	436	14	from	from	IN
cord-304876-txaoz7oh	436	15	73	73	CD
cord-304876-txaoz7oh	436	16	%	%	NN
cord-304876-txaoz7oh	436	17	to	to	TO
cord-304876-txaoz7oh	436	18	88	88	CD
cord-304876-txaoz7oh	436	19	%	%	NN
cord-304876-txaoz7oh	436	20	depending	depend	VBG
cord-304876-txaoz7oh	436	21	on	on	IN
cord-304876-txaoz7oh	436	22	the	the	DT
cord-304876-txaoz7oh	436	23	dose	dose	JJ
cord-304876-txaoz7oh	436	24	regimen	regimen	NN
cord-304876-txaoz7oh	436	25	.	.	.
cord-304876-txaoz7oh	437	1	RSV	RSV	NNP
cord-304876-txaoz7oh	437	2	RNA	RNA	NNP
cord-304876-txaoz7oh	437	3	was	be	VBD
cord-304876-txaoz7oh	437	4	undetectable	undetectable	JJ
cord-304876-txaoz7oh	437	5	1.3	1.3	CD
cord-304876-txaoz7oh	437	6	to	to	TO
cord-304876-txaoz7oh	437	7	2.3	2.3	CD
cord-304876-txaoz7oh	437	8	days	day	NNS
cord-304876-txaoz7oh	437	9	after	after	IN
cord-304876-txaoz7oh	437	10	the	the	DT
cord-304876-txaoz7oh	437	11	start	start	NN
cord-304876-txaoz7oh	437	12	of	of	IN
cord-304876-txaoz7oh	437	13	ALS-8176	als-8176	JJ
cord-304876-txaoz7oh	437	14	treatment	treatment	NN
cord-304876-txaoz7oh	437	15	compared	compare	VBN
cord-304876-txaoz7oh	437	16	with	with	IN
cord-304876-txaoz7oh	437	17	7.2	7.2	CD
cord-304876-txaoz7oh	437	18	days	day	NNS
cord-304876-txaoz7oh	437	19	for	for	IN
cord-304876-txaoz7oh	437	20	placebo	placebo	NN
cord-304876-txaoz7oh	437	21	.	.	.
cord-304876-txaoz7oh	438	1	Assessment	assessment	NN
cord-304876-txaoz7oh	438	2	of	of	IN
cord-304876-txaoz7oh	438	3	symptom	symptom	NN
cord-304876-txaoz7oh	438	4	scores	score	NNS
cord-304876-txaoz7oh	438	5	and	and	CC
cord-304876-txaoz7oh	438	6	quantity	quantity	NN
cord-304876-txaoz7oh	438	7	of	of	IN
cord-304876-txaoz7oh	438	8	mucus	mucus	NN
cord-304876-txaoz7oh	438	9	produced	produce	VBN
cord-304876-txaoz7oh	438	10	also	also	RB
cord-304876-txaoz7oh	438	11	showed	show	VBD
cord-304876-txaoz7oh	438	12	a	a	DT
cord-304876-txaoz7oh	438	13	clear	clear	JJ
cord-304876-txaoz7oh	438	14	effect	effect	NN
cord-304876-txaoz7oh	438	15	on	on	IN
cord-304876-txaoz7oh	438	16	RSV	RSV	NNP
cord-304876-txaoz7oh	438	17	-	-	HYPH
cord-304876-txaoz7oh	438	18	induced	induce	VBN
cord-304876-txaoz7oh	438	19	disease	disease	NN
cord-304876-txaoz7oh	438	20	.	.	.
cord-304876-txaoz7oh	439	1	This	this	DT
cord-304876-txaoz7oh	439	2	important	important	JJ
cord-304876-txaoz7oh	439	3	result	result	NN
cord-304876-txaoz7oh	439	4	represents	represent	VBZ
cord-304876-txaoz7oh	439	5	the	the	DT
cord-304876-txaoz7oh	439	6	first	first	JJ
cord-304876-txaoz7oh	439	7	proofof	proofof	JJ
cord-304876-txaoz7oh	439	8	-	-	HYPH
cord-304876-txaoz7oh	439	9	concept	concept	NN
cord-304876-txaoz7oh	439	10	validation	validation	NN
cord-304876-txaoz7oh	439	11	that	that	IN
cord-304876-txaoz7oh	439	12	an	an	DT
cord-304876-txaoz7oh	439	13	RSV	RSV	NNP
cord-304876-txaoz7oh	439	14	replication	replication	NN
cord-304876-txaoz7oh	439	15	inhibitor	inhibitor	NN
cord-304876-txaoz7oh	439	16	can	can	MD
cord-304876-txaoz7oh	439	17	be	be	VB
cord-304876-txaoz7oh	439	18	efficacious	efficacious	JJ
cord-304876-txaoz7oh	439	19	in	in	IN
cord-304876-txaoz7oh	439	20	humans	human	NNS
cord-304876-txaoz7oh	439	21	.	.	.
cord-304876-txaoz7oh	440	1	ALS-8176	ALS-8176	NNS
cord-304876-txaoz7oh	440	2	is	be	VBZ
cord-304876-txaoz7oh	440	3	currently	currently	RB
cord-304876-txaoz7oh	440	4	in	in	IN
cord-304876-txaoz7oh	440	5	clinical	clinical	JJ
cord-304876-txaoz7oh	440	6	development	development	NN
cord-304876-txaoz7oh	440	7	for	for	IN
cord-304876-txaoz7oh	440	8	the	the	DT
cord-304876-txaoz7oh	440	9	treatment	treatment	NN
cord-304876-txaoz7oh	440	10	of	of	IN
cord-304876-txaoz7oh	440	11	RSV	RSV	NNP
cord-304876-txaoz7oh	440	12	infection	infection	NN
cord-304876-txaoz7oh	440	13	in	in	IN
cord-304876-txaoz7oh	440	14	hospitalized	hospitalize	VBN
cord-304876-txaoz7oh	440	15	infants	infant	NNS
cord-304876-txaoz7oh	440	16	and	and	CC
cord-304876-txaoz7oh	440	17	adults	adult	NNS
cord-304876-txaoz7oh	440	18	(	(	-LRB-
cord-304876-txaoz7oh	440	19	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-304876-txaoz7oh	440	20	identifier	identifier	NN
cord-304876-txaoz7oh	440	21	:	:	:
cord-304876-txaoz7oh	440	22	NCT02202356	NCT02202356	NNP
cord-304876-txaoz7oh	440	23	,	,	,
cord-304876-txaoz7oh	440	24	NCT02935673	NCT02935673	NNP
cord-304876-txaoz7oh	440	25	)	)	-RRB-
cord-304876-txaoz7oh	440	26	.	.	.
cord-304876-txaoz7oh	441	1	The	the	DT
cord-304876-txaoz7oh	441	2	recent	recent	JJ
cord-304876-txaoz7oh	441	3	Ebola	Ebola	NNP
cord-304876-txaoz7oh	441	4	virus	virus	NN
cord-304876-txaoz7oh	441	5	outbreak	outbreak	NN
cord-304876-txaoz7oh	441	6	of	of	IN
cord-304876-txaoz7oh	441	7	2013	2013	CD
cord-304876-txaoz7oh	441	8	-	-	SYM
cord-304876-txaoz7oh	441	9	2016	2016	CD
cord-304876-txaoz7oh	441	10	in	in	IN
cord-304876-txaoz7oh	441	11	West	West	NNP
cord-304876-txaoz7oh	441	12	Africa	Africa	NNP
cord-304876-txaoz7oh	441	13	triggered	trigger	VBD
cord-304876-txaoz7oh	441	14	increased	increase	VBN
cord-304876-txaoz7oh	441	15	efforts	effort	NNS
cord-304876-txaoz7oh	441	16	to	to	TO
cord-304876-txaoz7oh	441	17	identify	identify	VB
cord-304876-txaoz7oh	441	18	new	new	JJ
cord-304876-txaoz7oh	441	19	antivirals	antiviral	NNS
cord-304876-txaoz7oh	441	20	targeting	target	VBG
cord-304876-txaoz7oh	441	21	filoviruses	filovirus	NNS
cord-304876-txaoz7oh	441	22	.	.	.
cord-304876-txaoz7oh	442	1	As	as	IN
cord-304876-txaoz7oh	442	2	a	a	DT
cord-304876-txaoz7oh	442	3	result	result	NN
cord-304876-txaoz7oh	442	4	,	,	,
cord-304876-txaoz7oh	442	5	the	the	DT
cord-304876-txaoz7oh	442	6	development	development	NN
cord-304876-txaoz7oh	442	7	of	of	IN
cord-304876-txaoz7oh	442	8	a	a	DT
cord-304876-txaoz7oh	442	9	new	new	JJ
cord-304876-txaoz7oh	442	10	series	series	NN
cord-304876-txaoz7oh	442	11	of	of	IN
cord-304876-txaoz7oh	442	12	C	C	NNP
cord-304876-txaoz7oh	442	13	-	-	HYPH
cord-304876-txaoz7oh	442	14	linked	link	VBN
cord-304876-txaoz7oh	442	15	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	442	16	analogs	analog	NNS
cord-304876-txaoz7oh	442	17	with	with	IN
cord-304876-txaoz7oh	442	18	anti	anti	JJ
cord-304876-txaoz7oh	442	19	-	-	JJ
cord-304876-txaoz7oh	442	20	Ebola	Ebola	NNP
cord-304876-txaoz7oh	442	21	properties	property	NNS
cord-304876-txaoz7oh	442	22	was	be	VBD
cord-304876-txaoz7oh	442	23	soon	soon	RB
cord-304876-txaoz7oh	442	24	reported	report	VBN
cord-304876-txaoz7oh	442	25	.	.	.
cord-304876-txaoz7oh	443	1	162	162	CD
cord-304876-txaoz7oh	444	1	In	in	IN
cord-304876-txaoz7oh	444	2	a	a	DT
cord-304876-txaoz7oh	444	3	cellbased	cellbased	JJ
cord-304876-txaoz7oh	444	4	infectious	infectious	JJ
cord-304876-txaoz7oh	444	5	assay	assay	NN
cord-304876-txaoz7oh	444	6	,	,	,
cord-304876-txaoz7oh	444	7	the	the	DT
cord-304876-txaoz7oh	444	8	1	1	CD
cord-304876-txaoz7oh	444	9	0	0	CD
cord-304876-txaoz7oh	444	10	-cyano	-cyano	NNP
cord-304876-txaoz7oh	444	11	C	c	NN
cord-304876-txaoz7oh	444	12	-	-	HYPH
cord-304876-txaoz7oh	444	13	linked	link	VBN
cord-304876-txaoz7oh	444	14	adenosine	adenosine	NN
cord-304876-txaoz7oh	444	15	derivative	derivative	NN
cord-304876-txaoz7oh	444	16	(	(	-LRB-
cord-304876-txaoz7oh	444	17	GS-441524	GS-441524	NNP
cord-304876-txaoz7oh	444	18	,	,	,
cord-304876-txaoz7oh	444	19	or	or	CC
cord-304876-txaoz7oh	444	20	compound	compound	NN
cord-304876-txaoz7oh	444	21	4	4	CD
cord-304876-txaoz7oh	444	22	)	)	-RRB-
cord-304876-txaoz7oh	444	23	was	be	VBD
cord-304876-txaoz7oh	444	24	moderately	moderately	RB
cord-304876-txaoz7oh	444	25	active	active	JJ
cord-304876-txaoz7oh	444	26	against	against	IN
cord-304876-txaoz7oh	444	27	Ebola	Ebola	NNP
cord-304876-txaoz7oh	444	28	replication	replication	NN
cord-304876-txaoz7oh	444	29	with	with	IN
cord-304876-txaoz7oh	444	30	EC	EC	NNP
cord-304876-txaoz7oh	444	31	50	50	CD
cord-304876-txaoz7oh	444	32	values	value	NNS
cord-304876-txaoz7oh	444	33	around	around	IN
cord-304876-txaoz7oh	444	34	1.5	1.5	CD
cord-304876-txaoz7oh	444	35	mM	mm	CD
cord-304876-txaoz7oh	444	36	,	,	,
cord-304876-txaoz7oh	444	37	whereas	whereas	IN
cord-304876-txaoz7oh	444	38	the	the	DT
cord-304876-txaoz7oh	444	39	1	1	CD
cord-304876-txaoz7oh	444	40	0	0	CD
cord-304876-txaoz7oh	444	41	-methyl	-methyl	NN
cord-304876-txaoz7oh	444	42	and	and	CC
cord-304876-txaoz7oh	444	43	-ethynyl	-ethynyl	CD
cord-304876-txaoz7oh	444	44	counterparts	counterpart	NNS
cord-304876-txaoz7oh	444	45	were	be	VBD
cord-304876-txaoz7oh	444	46	completely	completely	RB
cord-304876-txaoz7oh	444	47	inactive	inactive	JJ
cord-304876-txaoz7oh	444	48	.	.	.
cord-304876-txaoz7oh	445	1	GS-441524	GS-441524	NNP
cord-304876-txaoz7oh	445	2	is	be	VBZ
cord-304876-txaoz7oh	445	3	also	also	RB
cord-304876-txaoz7oh	445	4	a	a	DT
cord-304876-txaoz7oh	445	5	broad	broad	JJ
cord-304876-txaoz7oh	445	6	-	-	HYPH
cord-304876-txaoz7oh	445	7	spectrum	spectrum	NN
cord-304876-txaoz7oh	445	8	inhibitor	inhibitor	NN
cord-304876-txaoz7oh	445	9	of	of	IN
cord-304876-txaoz7oh	445	10	a	a	DT
cord-304876-txaoz7oh	445	11	variety	variety	NN
cord-304876-txaoz7oh	445	12	of	of	IN
cord-304876-txaoz7oh	445	13	RNA	RNA	NNP
cord-304876-txaoz7oh	445	14	viruses	virus	NNS
cord-304876-txaoz7oh	445	15	from	from	IN
cord-304876-txaoz7oh	445	16	four	four	CD
cord-304876-txaoz7oh	445	17	families	family	NNS
cord-304876-txaoz7oh	445	18	(	(	-LRB-
cord-304876-txaoz7oh	445	19	Filoviridae	Filoviridae	NNP
cord-304876-txaoz7oh	445	20	,	,	,
cord-304876-txaoz7oh	445	21	Flaviviridae	Flaviviridae	NNP
cord-304876-txaoz7oh	445	22	,	,	,
cord-304876-txaoz7oh	445	23	Paramyxoviridae	Paramyxoviridae	NNP
cord-304876-txaoz7oh	445	24	,	,	,
cord-304876-txaoz7oh	445	25	and	and	CC
cord-304876-txaoz7oh	445	26	Pneumoviridae	Pneumoviridae	NNP
cord-304876-txaoz7oh	445	27	)	)	-RRB-
cord-304876-txaoz7oh	445	28	,	,	,
cord-304876-txaoz7oh	445	29	including	include	VBG
cord-304876-txaoz7oh	445	30	HCV	HCV	NNP
cord-304876-txaoz7oh	445	31	and	and	CC
cord-304876-txaoz7oh	445	32	RSV	RSV	NNP
cord-304876-txaoz7oh	445	33	.	.	.
cord-304876-txaoz7oh	445	34	163	163	CD
cord-304876-txaoz7oh	445	35	,	,	,
cord-304876-txaoz7oh	445	36	164	164	CD
cord-304876-txaoz7oh	445	37	However	however	RB
cord-304876-txaoz7oh	445	38	,	,	,
cord-304876-txaoz7oh	445	39	the	the	DT
cord-304876-txaoz7oh	445	40	addition	addition	NN
cord-304876-txaoz7oh	445	41	of	of	IN
cord-304876-txaoz7oh	445	42	a	a	DT
cord-304876-txaoz7oh	445	43	2	2	CD
cord-304876-txaoz7oh	445	44	0	0	CD
cord-304876-txaoz7oh	445	45	-C	-c	ADD
cord-304876-txaoz7oh	445	46	-	-	HYPH
cord-304876-txaoz7oh	445	47	methyl	methyl	NN
cord-304876-txaoz7oh	445	48	group	group	NN
cord-304876-txaoz7oh	445	49	,	,	,
cord-304876-txaoz7oh	445	50	as	as	IN
cord-304876-txaoz7oh	445	51	in	in	IN
cord-304876-txaoz7oh	445	52	the	the	DT
cord-304876-txaoz7oh	445	53	case	case	NN
cord-304876-txaoz7oh	445	54	of	of	IN
cord-304876-txaoz7oh	445	55	the	the	DT
cord-304876-txaoz7oh	445	56	GS-6620	gs-6620	NN
cord-304876-txaoz7oh	445	57	,	,	,
cord-304876-txaoz7oh	445	58	165	165	CD
cord-304876-txaoz7oh	445	59	,	,	,
cord-304876-txaoz7oh	445	60	166	166	CD
cord-304876-txaoz7oh	445	61	significantly	significantly	RB
cord-304876-txaoz7oh	445	62	reduces	reduce	VBZ
cord-304876-txaoz7oh	445	63	the	the	DT
cord-304876-txaoz7oh	445	64	antiviral	antiviral	JJ
cord-304876-txaoz7oh	445	65	spectrum	spectrum	NN
cord-304876-txaoz7oh	445	66	to	to	IN
cord-304876-txaoz7oh	445	67	HCV	HCV	NNP
cord-304876-txaoz7oh	445	68	only	only	RB
cord-304876-txaoz7oh	445	69	.	.	.
cord-304876-txaoz7oh	446	1	The	the	DT
cord-304876-txaoz7oh	446	2	relatively	relatively	RB
cord-304876-txaoz7oh	446	3	weak	weak	JJ
cord-304876-txaoz7oh	446	4	antiviral	antiviral	JJ
cord-304876-txaoz7oh	446	5	activity	activity	NN
cord-304876-txaoz7oh	446	6	of	of	IN
cord-304876-txaoz7oh	446	7	GS-441524	GS-441524	NNS
cord-304876-txaoz7oh	446	8	across	across	IN
cord-304876-txaoz7oh	446	9	all	all	DT
cord-304876-txaoz7oh	446	10	viruses	virus	NNS
cord-304876-txaoz7oh	446	11	(	(	-LRB-
cord-304876-txaoz7oh	446	12	0.5	0.5	CD
cord-304876-txaoz7oh	446	13	-	-	SYM
cord-304876-txaoz7oh	446	14	50	50	CD
cord-304876-txaoz7oh	447	1	mM	mm	CD
cord-304876-txaoz7oh	447	2	EC	EC	NNP
cord-304876-txaoz7oh	447	3	50	50	CD
cord-304876-txaoz7oh	447	4	)	)	-RRB-
cord-304876-txaoz7oh	447	5	was	be	VBD
cord-304876-txaoz7oh	447	6	attributed	attribute	VBN
cord-304876-txaoz7oh	447	7	to	to	IN
cord-304876-txaoz7oh	447	8	its	-PRON-	PRP$
cord-304876-txaoz7oh	447	9	inefficient	inefficient	JJ
cord-304876-txaoz7oh	447	10	intracellular	intracellular	JJ
cord-304876-txaoz7oh	447	11	phosphorylation	phosphorylation	NN
cord-304876-txaoz7oh	447	12	,	,	,
cord-304876-txaoz7oh	447	13	which	which	WDT
cord-304876-txaoz7oh	447	14	could	could	MD
cord-304876-txaoz7oh	447	15	be	be	VB
cord-304876-txaoz7oh	447	16	improved	improve	VBN
cord-304876-txaoz7oh	447	17	by	by	IN
cord-304876-txaoz7oh	447	18	adding	add	VBG
cord-304876-txaoz7oh	447	19	a	a	DT
cord-304876-txaoz7oh	447	20	monophosphate	monophosphate	NN
cord-304876-txaoz7oh	447	21	prodrug	prodrug	NN
cord-304876-txaoz7oh	447	22	to	to	IN
cord-304876-txaoz7oh	447	23	the	the	DT
cord-304876-txaoz7oh	447	24	parent	parent	NN
cord-304876-txaoz7oh	447	25	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	447	26	.	.	.
cord-304876-txaoz7oh	448	1	The	the	DT
cord-304876-txaoz7oh	448	2	resulting	result	VBG
cord-304876-txaoz7oh	448	3	compound	compound	NN
cord-304876-txaoz7oh	448	4	,	,	,
cord-304876-txaoz7oh	448	5	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	448	6	(	(	-LRB-
cord-304876-txaoz7oh	448	7	Figure	figure	NN
cord-304876-txaoz7oh	448	8	5	5	CD
cord-304876-txaoz7oh	448	9	)	)	-RRB-
cord-304876-txaoz7oh	448	10	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	448	11	the	the	DT
cord-304876-txaoz7oh	448	12	Zaire	Zaire	NNP
cord-304876-txaoz7oh	448	13	and	and	CC
cord-304876-txaoz7oh	448	14	Sudan	Sudan	NNP
cord-304876-txaoz7oh	448	15	species	specie	NNS
cord-304876-txaoz7oh	448	16	of	of	IN
cord-304876-txaoz7oh	448	17	Ebola	Ebola	NNP
cord-304876-txaoz7oh	448	18	virus	virus	NN
cord-304876-txaoz7oh	448	19	and	and	CC
cord-304876-txaoz7oh	448	20	Marburg	Marburg	NNP
cord-304876-txaoz7oh	448	21	virus	virus	NN
cord-304876-txaoz7oh	448	22	with	with	IN
cord-304876-txaoz7oh	448	23	EC	EC	NNP
cord-304876-txaoz7oh	448	24	50	50	CD
cord-304876-txaoz7oh	448	25	values	value	NNS
cord-304876-txaoz7oh	448	26	ranging	range	VBG
cord-304876-txaoz7oh	448	27	from	from	IN
cord-304876-txaoz7oh	448	28	0.01	0.01	CD
cord-304876-txaoz7oh	448	29	to	to	IN
cord-304876-txaoz7oh	448	30	0.20	0.20	CD
cord-304876-txaoz7oh	448	31	mM	mm	CD
cord-304876-txaoz7oh	448	32	,	,	,
cord-304876-txaoz7oh	448	33	and	and	CC
cord-304876-txaoz7oh	448	34	exhibits	exhibit	VBZ
cord-304876-txaoz7oh	448	35	moderate	moderate	JJ
cord-304876-txaoz7oh	448	36	cytotoxicity	cytotoxicity	NN
cord-304876-txaoz7oh	448	37	(	(	-LRB-
cord-304876-txaoz7oh	448	38	CC	cc	NN
cord-304876-txaoz7oh	448	39	50	50	CD
cord-304876-txaoz7oh	448	40	¼	¼	CD
cord-304876-txaoz7oh	448	41	2	2	CD
cord-304876-txaoz7oh	448	42	to	to	IN
cord-304876-txaoz7oh	448	43	>	>	XX
cord-304876-txaoz7oh	448	44	20	20	CD
cord-304876-txaoz7oh	448	45	mM	mm	CD
cord-304876-txaoz7oh	448	46	)	)	-RRB-
cord-304876-txaoz7oh	448	47	in	in	IN
cord-304876-txaoz7oh	448	48	multiple	multiple	JJ
cord-304876-txaoz7oh	448	49	human	human	JJ
cord-304876-txaoz7oh	448	50	cell	cell	NN
cord-304876-txaoz7oh	448	51	types	type	NNS
cord-304876-txaoz7oh	448	52	.	.	.
cord-304876-txaoz7oh	449	1	GS-5734	GS-5734	NNP
cord-304876-txaoz7oh	449	2	exhibits	exhibit	VBZ
cord-304876-txaoz7oh	449	3	the	the	DT
cord-304876-txaoz7oh	449	4	same	same	JJ
cord-304876-txaoz7oh	449	5	broad	broad	JJ
cord-304876-txaoz7oh	449	6	antiviral	antiviral	JJ
cord-304876-txaoz7oh	449	7	spectrum	spectrum	NN
cord-304876-txaoz7oh	449	8	as	as	IN
cord-304876-txaoz7oh	449	9	its	-PRON-	PRP$
cord-304876-txaoz7oh	449	10	parent	parent	NN
cord-304876-txaoz7oh	449	11	molecule	molecule	NN
cord-304876-txaoz7oh	449	12	.	.	.
cord-304876-txaoz7oh	450	1	163	163	CD
cord-304876-txaoz7oh	451	1	The	the	DT
cord-304876-txaoz7oh	451	2	triphosphate	triphosphate	NN
cord-304876-txaoz7oh	451	3	form	form	NN
cord-304876-txaoz7oh	451	4	of	of	IN
cord-304876-txaoz7oh	451	5	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	451	6	is	be	VBZ
cord-304876-txaoz7oh	451	7	recognized	recognize	VBN
cord-304876-txaoz7oh	451	8	as	as	IN
cord-304876-txaoz7oh	451	9	substrate	substrate	NN
cord-304876-txaoz7oh	451	10	by	by	IN
cord-304876-txaoz7oh	451	11	RSV	RSV	NNP
cord-304876-txaoz7oh	451	12	polymerase	polymerase	NN
cord-304876-txaoz7oh	451	13	,	,	,
cord-304876-txaoz7oh	451	14	but	but	CC
cord-304876-txaoz7oh	451	15	its	-PRON-	PRP$
cord-304876-txaoz7oh	451	16	incorporation	incorporation	NN
cord-304876-txaoz7oh	451	17	into	into	IN
cord-304876-txaoz7oh	451	18	RNA	RNA	NNP
cord-304876-txaoz7oh	451	19	does	do	VBZ
cord-304876-txaoz7oh	451	20	not	not	RB
cord-304876-txaoz7oh	451	21	lead	lead	VB
cord-304876-txaoz7oh	451	22	to	to	IN
cord-304876-txaoz7oh	451	23	immediate	immediate	JJ
cord-304876-txaoz7oh	451	24	chain	chain	NN
cord-304876-txaoz7oh	451	25	termination	termination	NN
cord-304876-txaoz7oh	451	26	.	.	.
cord-304876-txaoz7oh	452	1	162	162	CD
cord-304876-txaoz7oh	453	1	The	the	DT
cord-304876-txaoz7oh	453	2	favorable	favorable	JJ
cord-304876-txaoz7oh	453	3	in	in	FW
cord-304876-txaoz7oh	453	4	vitro	vitro	FW
cord-304876-txaoz7oh	453	5	data	datum	NNS
cord-304876-txaoz7oh	453	6	led	lead	VBD
cord-304876-txaoz7oh	453	7	to	to	IN
cord-304876-txaoz7oh	453	8	further	further	JJ
cord-304876-txaoz7oh	453	9	evaluation	evaluation	NN
cord-304876-txaoz7oh	453	10	of	of	IN
cord-304876-txaoz7oh	453	11	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	453	12	in	in	IN
cord-304876-txaoz7oh	453	13	a	a	DT
cord-304876-txaoz7oh	453	14	macaque	macaque	JJ
cord-304876-txaoz7oh	453	15	lethal	lethal	JJ
cord-304876-txaoz7oh	453	16	model	model	NN
cord-304876-txaoz7oh	453	17	of	of	IN
cord-304876-txaoz7oh	453	18	Ebola	Ebola	NNP
cord-304876-txaoz7oh	453	19	virus	virus	NN
cord-304876-txaoz7oh	453	20	disease	disease	NN
cord-304876-txaoz7oh	453	21	.	.	.
cord-304876-txaoz7oh	454	1	Complete	complete	JJ
cord-304876-txaoz7oh	454	2	protection	protection	NN
cord-304876-txaoz7oh	454	3	was	be	VBD
cord-304876-txaoz7oh	454	4	achieved	achieve	VBN
cord-304876-txaoz7oh	454	5	when	when	WRB
cord-304876-txaoz7oh	454	6	GS-5734	GS-5734	NNP
cord-304876-txaoz7oh	454	7	was	be	VBD
cord-304876-txaoz7oh	454	8	administered	administer	VBN
cord-304876-txaoz7oh	454	9	at	at	IN
cord-304876-txaoz7oh	454	10	a	a	DT
cord-304876-txaoz7oh	454	11	daily	daily	JJ
cord-304876-txaoz7oh	454	12	intravenous	intravenous	JJ
cord-304876-txaoz7oh	454	13	dose	dose	NN
cord-304876-txaoz7oh	454	14	of	of	IN
cord-304876-txaoz7oh	454	15	10	10	CD
cord-304876-txaoz7oh	454	16	mg	mg	NNP
cord-304876-txaoz7oh	454	17	/	/	SYM
cord-304876-txaoz7oh	454	18	kg	kg	NNP
cord-304876-txaoz7oh	454	19	,	,	,
cord-304876-txaoz7oh	454	20	beginning	begin	VBG
cord-304876-txaoz7oh	454	21	on	on	IN
cord-304876-txaoz7oh	454	22	Day	day	NN
cord-304876-txaoz7oh	454	23	3	3	CD
cord-304876-txaoz7oh	454	24	post	post	NN
cord-304876-txaoz7oh	454	25	-	-	NN
cord-304876-txaoz7oh	454	26	infection	infection	NN
cord-304876-txaoz7oh	454	27	.	.	.
cord-304876-txaoz7oh	455	1	162	162	CD
cord-304876-txaoz7oh	456	1	Following	follow	VBG
cord-304876-txaoz7oh	456	2	Phase	phase	NN
cord-304876-txaoz7oh	457	1	I	-PRON-	PRP
cord-304876-txaoz7oh	457	2	safety	safety	NN
cord-304876-txaoz7oh	457	3	testing	testing	NN
cord-304876-txaoz7oh	457	4	in	in	IN
cord-304876-txaoz7oh	457	5	healthy	healthy	JJ
cord-304876-txaoz7oh	457	6	human	human	JJ
cord-304876-txaoz7oh	457	7	volunteers	volunteer	NNS
cord-304876-txaoz7oh	457	8	,	,	,
cord-304876-txaoz7oh	457	9	GS-5724	GS-5724	NNS
cord-304876-txaoz7oh	457	10	was	be	VBD
cord-304876-txaoz7oh	457	11	first	first	RB
cord-304876-txaoz7oh	457	12	given	give	VBN
cord-304876-txaoz7oh	457	13	as	as	IN
cord-304876-txaoz7oh	457	14	a	a	DT
cord-304876-txaoz7oh	457	15	14-day	14-day	CD
cord-304876-txaoz7oh	457	16	course	course	NN
cord-304876-txaoz7oh	457	17	for	for	IN
cord-304876-txaoz7oh	457	18	compassionate	compassionate	JJ
cord-304876-txaoz7oh	457	19	use	use	NN
cord-304876-txaoz7oh	457	20	to	to	IN
cord-304876-txaoz7oh	457	21	an	an	DT
cord-304876-txaoz7oh	457	22	Ebola	Ebola	NNP
cord-304876-txaoz7oh	457	23	-	-	HYPH
cord-304876-txaoz7oh	457	24	infected	infect	VBN
cord-304876-txaoz7oh	457	25	nurse	nurse	NN
cord-304876-txaoz7oh	457	26	who	who	WP
cord-304876-txaoz7oh	457	27	had	have	VBD
cord-304876-txaoz7oh	457	28	survived	survive	VBN
cord-304876-txaoz7oh	457	29	the	the	DT
cord-304876-txaoz7oh	457	30	disease	disease	NN
cord-304876-txaoz7oh	457	31	and	and	CC
cord-304876-txaoz7oh	457	32	developed	develop	VBD
cord-304876-txaoz7oh	457	33	a	a	DT
cord-304876-txaoz7oh	457	34	recurrence	recurrence	NN
cord-304876-txaoz7oh	457	35	in	in	IN
cord-304876-txaoz7oh	457	36	the	the	DT
cord-304876-txaoz7oh	457	37	central	central	JJ
cord-304876-txaoz7oh	457	38	nervous	nervous	JJ
cord-304876-txaoz7oh	457	39	system	system	NN
cord-304876-txaoz7oh	457	40	.	.	.
cord-304876-txaoz7oh	458	1	167	167	CD
cord-304876-txaoz7oh	459	1	Soon	soon	RB
cord-304876-txaoz7oh	459	2	after	after	RB
cord-304876-txaoz7oh	459	3	,	,	,
cord-304876-txaoz7oh	459	4	a	a	DT
cord-304876-txaoz7oh	459	5	neonate	neonate	NN
cord-304876-txaoz7oh	459	6	who	who	WP
cord-304876-txaoz7oh	459	7	had	have	VBD
cord-304876-txaoz7oh	459	8	congenital	congenital	JJ
cord-304876-txaoz7oh	459	9	Ebola	Ebola	NNP
cord-304876-txaoz7oh	459	10	virus	virus	NN
cord-304876-txaoz7oh	459	11	infection	infection	NN
cord-304876-txaoz7oh	459	12	received	receive	VBD
cord-304876-txaoz7oh	459	13	three	three	CD
cord-304876-txaoz7oh	459	14	different	different	JJ
cord-304876-txaoz7oh	459	15	experimental	experimental	JJ
cord-304876-txaoz7oh	459	16	therapies	therapy	NNS
cord-304876-txaoz7oh	459	17	,	,	,
cord-304876-txaoz7oh	459	18	including	include	VBG
cord-304876-txaoz7oh	459	19	a	a	DT
cord-304876-txaoz7oh	459	20	12-day	12-day	CD
cord-304876-txaoz7oh	459	21	treatment	treatment	NN
cord-304876-txaoz7oh	459	22	with	with	IN
cord-304876-txaoz7oh	459	23	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	459	24	.	.	.
cord-304876-txaoz7oh	460	1	168	168	CD
cord-304876-txaoz7oh	461	1	In	in	IN
cord-304876-txaoz7oh	461	2	both	both	DT
cord-304876-txaoz7oh	461	3	cases	case	NNS
cord-304876-txaoz7oh	461	4	,	,	,
cord-304876-txaoz7oh	461	5	patients	patient	NNS
cord-304876-txaoz7oh	461	6	cleared	clear	VBD
cord-304876-txaoz7oh	461	7	the	the	DT
cord-304876-txaoz7oh	461	8	virus	virus	NN
cord-304876-txaoz7oh	461	9	and	and	CC
cord-304876-txaoz7oh	461	10	survived	survive	VBD
cord-304876-txaoz7oh	461	11	the	the	DT
cord-304876-txaoz7oh	461	12	infection	infection	NN
cord-304876-txaoz7oh	461	13	.	.	.
cord-304876-txaoz7oh	462	1	The	the	DT
cord-304876-txaoz7oh	462	2	characterization	characterization	NN
cord-304876-txaoz7oh	462	3	of	of	IN
cord-304876-txaoz7oh	462	4	the	the	DT
cord-304876-txaoz7oh	462	5	broad	broad	JJ
cord-304876-txaoz7oh	462	6	antiviral	antiviral	JJ
cord-304876-txaoz7oh	462	7	spectrum	spectrum	NN
cord-304876-txaoz7oh	462	8	of	of	IN
cord-304876-txaoz7oh	462	9	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	462	10	was	be	VBD
cord-304876-txaoz7oh	462	11	further	further	RB
cord-304876-txaoz7oh	462	12	expanded	expand	VBN
cord-304876-txaoz7oh	462	13	to	to	IN
cord-304876-txaoz7oh	462	14	another	another	DT
cord-304876-txaoz7oh	462	15	(	(	-LRB-
cord-304876-txaoz7oh	462	16	þ	þ	NN
cord-304876-txaoz7oh	462	17	)	)	-RRB-
cord-304876-txaoz7oh	462	18	ssRNA	ssRNA	-RRB-
cord-304876-txaoz7oh	462	19	virus	virus	NN
cord-304876-txaoz7oh	462	20	family	family	NN
cord-304876-txaoz7oh	462	21	:	:	:
cord-304876-txaoz7oh	462	22	Coronaviridae	Coronaviridae	NNP
cord-304876-txaoz7oh	462	23	.	.	.
cord-304876-txaoz7oh	463	1	It	-PRON-	PRP
cord-304876-txaoz7oh	463	2	was	be	VBD
cord-304876-txaoz7oh	463	3	shown	show	VBN
cord-304876-txaoz7oh	463	4	that	that	IN
cord-304876-txaoz7oh	463	5	GS-5734	GS-5734	NNP
cord-304876-txaoz7oh	463	6	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	463	7	SARS	SARS	NNP
cord-304876-txaoz7oh	463	8	-	-	HYPH
cord-304876-txaoz7oh	463	9	CoV	CoV	NNP
cord-304876-txaoz7oh	463	10	and	and	CC
cord-304876-txaoz7oh	463	11	MERS	MERS	NNP
cord-304876-txaoz7oh	463	12	-	-	HYPH
cord-304876-txaoz7oh	463	13	CoV	cov	NN
cord-304876-txaoz7oh	463	14	replication	replication	NN
cord-304876-txaoz7oh	463	15	in	in	IN
cord-304876-txaoz7oh	463	16	multiple	multiple	NN
cord-304876-txaoz7oh	463	17	in	in	IN
cord-304876-txaoz7oh	463	18	vitro	vitro	FW
cord-304876-txaoz7oh	463	19	systems	system	NNS
cord-304876-txaoz7oh	463	20	,	,	,
cord-304876-txaoz7oh	463	21	including	include	VBG
cord-304876-txaoz7oh	463	22	primary	primary	JJ
cord-304876-txaoz7oh	463	23	human	human	JJ
cord-304876-txaoz7oh	463	24	airway	airway	NN
cord-304876-txaoz7oh	463	25	epithelial	epithelial	JJ
cord-304876-txaoz7oh	463	26	cell	cell	NN
cord-304876-txaoz7oh	463	27	cultures	culture	NNS
cord-304876-txaoz7oh	463	28	with	with	IN
cord-304876-txaoz7oh	463	29	sub	sub	JJ
cord-304876-txaoz7oh	463	30	-	-	JJ
cord-304876-txaoz7oh	463	31	micromolar	micromolar	JJ
cord-304876-txaoz7oh	463	32	EC	EC	NNP
cord-304876-txaoz7oh	463	33	50	50	CD
cord-304876-txaoz7oh	463	34	values	value	NNS
cord-304876-txaoz7oh	463	35	.	.	.
cord-304876-txaoz7oh	464	1	169	169	CD
cord-304876-txaoz7oh	464	2	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	464	3	was	be	VBD
cord-304876-txaoz7oh	464	4	also	also	RB
cord-304876-txaoz7oh	464	5	effective	effective	JJ
cord-304876-txaoz7oh	464	6	against	against	IN
cord-304876-txaoz7oh	464	7	other	other	JJ
cord-304876-txaoz7oh	464	8	human	human	NN
cord-304876-txaoz7oh	464	9	and	and	CC
cord-304876-txaoz7oh	464	10	bat	bat	NN
cord-304876-txaoz7oh	465	1	CoV.	CoV.	NNP
cord-304876-txaoz7oh	466	1	In	in	IN
cord-304876-txaoz7oh	466	2	a	a	DT
cord-304876-txaoz7oh	466	3	mouse	mouse	NN
cord-304876-txaoz7oh	466	4	model	model	NN
cord-304876-txaoz7oh	466	5	of	of	IN
cord-304876-txaoz7oh	466	6	SARS	SARS	NNP
cord-304876-txaoz7oh	466	7	-	-	HYPH
cord-304876-txaoz7oh	466	8	CoV	CoV	NNP
cord-304876-txaoz7oh	466	9	infection	infection	NN
cord-304876-txaoz7oh	466	10	,	,	,
cord-304876-txaoz7oh	466	11	prophylactic	prophylactic	JJ
cord-304876-txaoz7oh	466	12	and	and	CC
cord-304876-txaoz7oh	466	13	early	early	JJ
cord-304876-txaoz7oh	466	14	therapeutic	therapeutic	JJ
cord-304876-txaoz7oh	466	15	administration	administration	NN
cord-304876-txaoz7oh	466	16	of	of	IN
cord-304876-txaoz7oh	466	17	GS-5734	GS-5734	NNP
cord-304876-txaoz7oh	466	18	reduced	reduce	VBN
cord-304876-txaoz7oh	466	19	lung	lung	NN
cord-304876-txaoz7oh	466	20	viral	viral	JJ
cord-304876-txaoz7oh	466	21	load	load	NN
cord-304876-txaoz7oh	466	22	and	and	CC
cord-304876-txaoz7oh	466	23	improved	improve	VBN
cord-304876-txaoz7oh	466	24	clinical	clinical	JJ
cord-304876-txaoz7oh	466	25	signs	sign	NNS
cord-304876-txaoz7oh	466	26	of	of	IN
cord-304876-txaoz7oh	466	27	disease	disease	NN
cord-304876-txaoz7oh	466	28	as	as	RB
cord-304876-txaoz7oh	466	29	well	well	RB
cord-304876-txaoz7oh	466	30	as	as	IN
cord-304876-txaoz7oh	466	31	respiratory	respiratory	JJ
cord-304876-txaoz7oh	466	32	function	function	NN
cord-304876-txaoz7oh	466	33	.	.	.
cord-304876-txaoz7oh	467	1	Although	although	IN
cord-304876-txaoz7oh	467	2	there	there	EX
cord-304876-txaoz7oh	467	3	is	be	VBZ
cord-304876-txaoz7oh	467	4	limited	limited	JJ
cord-304876-txaoz7oh	467	5	data	datum	NNS
cord-304876-txaoz7oh	467	6	to	to	TO
cord-304876-txaoz7oh	467	7	confirm	confirm	VB
cord-304876-txaoz7oh	467	8	the	the	DT
cord-304876-txaoz7oh	467	9	proposed	propose	VBN
cord-304876-txaoz7oh	467	10	mechanism	mechanism	NN
cord-304876-txaoz7oh	467	11	of	of	IN
cord-304876-txaoz7oh	467	12	action	action	NN
cord-304876-txaoz7oh	467	13	of	of	IN
cord-304876-txaoz7oh	467	14	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	467	15	against	against	IN
cord-304876-txaoz7oh	467	16	each	each	DT
cord-304876-txaoz7oh	467	17	virus	virus	NN
cord-304876-txaoz7oh	467	18	,	,	,
cord-304876-txaoz7oh	467	19	it	-PRON-	PRP
cord-304876-txaoz7oh	467	20	is	be	VBZ
cord-304876-txaoz7oh	467	21	generally	generally	RB
cord-304876-txaoz7oh	467	22	assumed	assume	VBN
cord-304876-txaoz7oh	467	23	that	that	IN
cord-304876-txaoz7oh	467	24	the	the	DT
cord-304876-txaoz7oh	467	25	molecule	molecule	NN
cord-304876-txaoz7oh	467	26	targets	target	VBZ
cord-304876-txaoz7oh	467	27	the	the	DT
cord-304876-txaoz7oh	467	28	RdRp	RdRp	NNP
cord-304876-txaoz7oh	467	29	function	function	NN
cord-304876-txaoz7oh	467	30	of	of	IN
cord-304876-txaoz7oh	467	31	the	the	DT
cord-304876-txaoz7oh	467	32	viral	viral	JJ
cord-304876-txaoz7oh	467	33	polymerase	polymerase	NN
cord-304876-txaoz7oh	467	34	.	.	.
cord-304876-txaoz7oh	468	1	In	in	IN
cord-304876-txaoz7oh	468	2	the	the	DT
cord-304876-txaoz7oh	468	3	case	case	NN
cord-304876-txaoz7oh	468	4	of	of	IN
cord-304876-txaoz7oh	468	5	CoV	CoV	NNP
cord-304876-txaoz7oh	468	6	,	,	,
cord-304876-txaoz7oh	468	7	this	this	DT
cord-304876-txaoz7oh	468	8	is	be	VBZ
cord-304876-txaoz7oh	468	9	supported	support	VBN
cord-304876-txaoz7oh	468	10	by	by	IN
cord-304876-txaoz7oh	468	11	the	the	DT
cord-304876-txaoz7oh	468	12	identification	identification	NN
cord-304876-txaoz7oh	468	13	of	of	IN
cord-304876-txaoz7oh	468	14	two	two	CD
cord-304876-txaoz7oh	468	15	mutations	mutation	NNS
cord-304876-txaoz7oh	468	16	(	(	-LRB-
cord-304876-txaoz7oh	468	17	F476L	F476L	NNP
cord-304876-txaoz7oh	468	18	and	and	CC
cord-304876-txaoz7oh	468	19	V553L	V553L	NNP
cord-304876-txaoz7oh	468	20	)	)	-RRB-
cord-304876-txaoz7oh	468	21	within	within	IN
cord-304876-txaoz7oh	468	22	the	the	DT
cord-304876-txaoz7oh	468	23	predicted	predict	VBN
cord-304876-txaoz7oh	468	24	fingers	finger	NNS
cord-304876-txaoz7oh	468	25	subdomain	subdomain	NN
cord-304876-txaoz7oh	468	26	of	of	IN
cord-304876-txaoz7oh	468	27	the	the	DT
cord-304876-txaoz7oh	468	28	RdRp	RdRp	NNP
cord-304876-txaoz7oh	468	29	protein	protein	NN
cord-304876-txaoz7oh	468	30	nsp12	nsp12	CD
cord-304876-txaoz7oh	468	31	from	from	IN
cord-304876-txaoz7oh	468	32	murine	murine	JJ
cord-304876-txaoz7oh	468	33	hepatitis	hepatitis	NN
cord-304876-txaoz7oh	468	34	virus	virus	NN
cord-304876-txaoz7oh	468	35	.	.	.
cord-304876-txaoz7oh	469	1	170	170	CD
cord-304876-txaoz7oh	470	1	These	these	DT
cord-304876-txaoz7oh	470	2	mutations	mutation	NNS
cord-304876-txaoz7oh	470	3	emerged	emerge	VBD
cord-304876-txaoz7oh	470	4	over	over	IN
cord-304876-txaoz7oh	470	5	23	23	CD
cord-304876-txaoz7oh	470	6	passages	passage	NNS
cord-304876-txaoz7oh	470	7	and	and	CC
cord-304876-txaoz7oh	470	8	confer	confer	VB
cord-304876-txaoz7oh	470	9	4-to	4-to	CD
cord-304876-txaoz7oh	470	10	6-fold	6-fold	CD
cord-304876-txaoz7oh	470	11	resistance	resistance	NN
cord-304876-txaoz7oh	470	12	to	to	IN
cord-304876-txaoz7oh	470	13	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	470	14	,	,	,
cord-304876-txaoz7oh	470	15	combined	combine	VBN
cord-304876-txaoz7oh	470	16	with	with	IN
cord-304876-txaoz7oh	470	17	overall	overall	JJ
cord-304876-txaoz7oh	470	18	reduced	reduce	VBN
cord-304876-txaoz7oh	470	19	replication	replication	NN
cord-304876-txaoz7oh	470	20	fitness	fitness	NN
cord-304876-txaoz7oh	470	21	.	.	.
cord-304876-txaoz7oh	471	1	At	at	IN
cord-304876-txaoz7oh	471	2	this	this	DT
cord-304876-txaoz7oh	471	3	point	point	NN
cord-304876-txaoz7oh	471	4	,	,	,
cord-304876-txaoz7oh	471	5	the	the	DT
cord-304876-txaoz7oh	471	6	precise	precise	JJ
cord-304876-txaoz7oh	471	7	mechanism	mechanism	NN
cord-304876-txaoz7oh	471	8	of	of	IN
cord-304876-txaoz7oh	471	9	action	action	NN
cord-304876-txaoz7oh	471	10	of	of	IN
cord-304876-txaoz7oh	471	11	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	471	12	against	against	IN
cord-304876-txaoz7oh	471	13	CoV	CoV	NNP
cord-304876-txaoz7oh	471	14	remains	remain	VBZ
cord-304876-txaoz7oh	471	15	elusive	elusive	JJ
cord-304876-txaoz7oh	471	16	.	.	.
cord-304876-txaoz7oh	472	1	It	-PRON-	PRP
cord-304876-txaoz7oh	472	2	is	be	VBZ
cord-304876-txaoz7oh	472	3	possible	possible	JJ
cord-304876-txaoz7oh	472	4	that	that	IN
cord-304876-txaoz7oh	472	5	GS-5734	GS-5734	NNP
cord-304876-txaoz7oh	472	6	triphosphate	triphosphate	NN
cord-304876-txaoz7oh	472	7	is	be	VBZ
cord-304876-txaoz7oh	472	8	not	not	RB
cord-304876-txaoz7oh	472	9	excised	excise	VBN
cord-304876-txaoz7oh	472	10	by	by	IN
cord-304876-txaoz7oh	472	11	the	the	DT
cord-304876-txaoz7oh	472	12	proofreading	proofreading	NN
cord-304876-txaoz7oh	472	13	activity	activity	NN
cord-304876-txaoz7oh	472	14	of	of	IN
cord-304876-txaoz7oh	472	15	nsp14	nsp14	DT
cord-304876-txaoz7oh	472	16	because	because	IN
cord-304876-txaoz7oh	472	17	of	of	IN
cord-304876-txaoz7oh	472	18	lack	lack	NN
cord-304876-txaoz7oh	472	19	of	of	IN
cord-304876-txaoz7oh	472	20	immediate	immediate	JJ
cord-304876-txaoz7oh	472	21	chain	chain	NN
cord-304876-txaoz7oh	472	22	termination	termination	NN
cord-304876-txaoz7oh	472	23	,	,	,
cord-304876-txaoz7oh	472	24	as	as	IN
cord-304876-txaoz7oh	472	25	observed	observe	VBN
cord-304876-txaoz7oh	472	26	for	for	IN
cord-304876-txaoz7oh	472	27	RSV	RSV	NNP
cord-304876-txaoz7oh	472	28	polymerase	polymerase	NN
cord-304876-txaoz7oh	472	29	.	.	.
cord-304876-txaoz7oh	473	1	In	in	IN
cord-304876-txaoz7oh	473	2	this	this	DT
cord-304876-txaoz7oh	473	3	case	case	NN
cord-304876-txaoz7oh	473	4	,	,	,
cord-304876-txaoz7oh	473	5	could	could	MD
cord-304876-txaoz7oh	473	6	the	the	DT
cord-304876-txaoz7oh	473	7	resistance	resistance	NN
cord-304876-txaoz7oh	473	8	mutations	mutation	NNS
cord-304876-txaoz7oh	473	9	identified	identify	VBN
cord-304876-txaoz7oh	473	10	in	in	IN
cord-304876-txaoz7oh	473	11	nsp12	nsp12	CD
cord-304876-txaoz7oh	473	12	alter	alter	VB
cord-304876-txaoz7oh	473	13	the	the	DT
cord-304876-txaoz7oh	473	14	chain	chain	NN
cord-304876-txaoz7oh	473	15	termination	termination	NN
cord-304876-txaoz7oh	473	16	profile	profile	NN
cord-304876-txaoz7oh	473	17	of	of	IN
cord-304876-txaoz7oh	473	18	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	473	19	,	,	,
cord-304876-txaoz7oh	473	20	and	and	CC
cord-304876-txaoz7oh	473	21	make	make	VB
cord-304876-txaoz7oh	473	22	it	-PRON-	PRP
cord-304876-txaoz7oh	473	23	more	more	RBR
cord-304876-txaoz7oh	473	24	susceptible	susceptible	JJ
cord-304876-txaoz7oh	473	25	to	to	IN
cord-304876-txaoz7oh	473	26	excision	excision	NN
cord-304876-txaoz7oh	473	27	?	?	.
cord-304876-txaoz7oh	474	1	Such	such	JJ
cord-304876-txaoz7oh	474	2	studies	study	NNS
cord-304876-txaoz7oh	474	3	are	be	VBP
cord-304876-txaoz7oh	474	4	needed	need	VBN
cord-304876-txaoz7oh	474	5	,	,	,
cord-304876-txaoz7oh	474	6	not	not	RB
cord-304876-txaoz7oh	474	7	only	only	RB
cord-304876-txaoz7oh	474	8	to	to	TO
cord-304876-txaoz7oh	474	9	understand	understand	VB
cord-304876-txaoz7oh	474	10	how	how	WRB
cord-304876-txaoz7oh	474	11	GS-5734	GS-5734	NNP
cord-304876-txaoz7oh	474	12	works	work	VBZ
cord-304876-txaoz7oh	474	13	but	but	CC
cord-304876-txaoz7oh	474	14	also	also	RB
cord-304876-txaoz7oh	474	15	to	to	TO
cord-304876-txaoz7oh	474	16	design	design	VB
cord-304876-txaoz7oh	474	17	new	new	JJ
cord-304876-txaoz7oh	474	18	molecules	molecule	NNS
cord-304876-txaoz7oh	474	19	against	against	IN
cord-304876-txaoz7oh	474	20	CoV	cov	NN
cord-304876-txaoz7oh	474	21	polymerases	polymerase	NNS
cord-304876-txaoz7oh	474	22	.	.	.
cord-304876-txaoz7oh	475	1	In	in	IN
cord-304876-txaoz7oh	475	2	this	this	DT
cord-304876-txaoz7oh	475	3	review	review	NN
cord-304876-txaoz7oh	475	4	,	,	,
cord-304876-txaoz7oh	475	5	we	-PRON-	PRP
cord-304876-txaoz7oh	475	6	summarized	summarize	VBD
cord-304876-txaoz7oh	475	7	the	the	DT
cord-304876-txaoz7oh	475	8	exciting	exciting	JJ
cord-304876-txaoz7oh	475	9	advances	advance	NNS
cord-304876-txaoz7oh	475	10	in	in	IN
cord-304876-txaoz7oh	475	11	discovery	discovery	NN
cord-304876-txaoz7oh	475	12	and	and	CC
cord-304876-txaoz7oh	475	13	development	development	NN
cord-304876-txaoz7oh	475	14	of	of	IN
cord-304876-txaoz7oh	475	15	novel	novel	JJ
cord-304876-txaoz7oh	475	16	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	475	17	analogs	analog	NNS
cord-304876-txaoz7oh	475	18	as	as	IN
cord-304876-txaoz7oh	475	19	potential	potential	JJ
cord-304876-txaoz7oh	475	20	new	new	JJ
cord-304876-txaoz7oh	475	21	treatments	treatment	NNS
cord-304876-txaoz7oh	475	22	for	for	IN
cord-304876-txaoz7oh	475	23	respiratory	respiratory	JJ
cord-304876-txaoz7oh	475	24	RNA	RNA	NNP
cord-304876-txaoz7oh	475	25	virus	virus	NN
cord-304876-txaoz7oh	475	26	infections	infection	NNS
cord-304876-txaoz7oh	475	27	.	.	.
cord-304876-txaoz7oh	476	1	The	the	DT
cord-304876-txaoz7oh	476	2	medical	medical	JJ
cord-304876-txaoz7oh	476	3	need	need	NN
cord-304876-txaoz7oh	476	4	is	be	VBZ
cord-304876-txaoz7oh	476	5	high	high	JJ
cord-304876-txaoz7oh	476	6	because	because	IN
cord-304876-txaoz7oh	476	7	very	very	RB
cord-304876-txaoz7oh	476	8	few	few	JJ
cord-304876-txaoz7oh	476	9	drugs	drug	NNS
cord-304876-txaoz7oh	476	10	have	have	VBP
cord-304876-txaoz7oh	476	11	been	be	VBN
cord-304876-txaoz7oh	476	12	approved	approve	VBN
cord-304876-txaoz7oh	476	13	for	for	IN
cord-304876-txaoz7oh	476	14	the	the	DT
cord-304876-txaoz7oh	476	15	treatment	treatment	NN
cord-304876-txaoz7oh	476	16	of	of	IN
cord-304876-txaoz7oh	476	17	respiratory	respiratory	JJ
cord-304876-txaoz7oh	476	18	viral	viral	JJ
cord-304876-txaoz7oh	476	19	infections	infection	NNS
cord-304876-txaoz7oh	476	20	despite	despite	IN
cord-304876-txaoz7oh	476	21	worldwide	worldwide	JJ
cord-304876-txaoz7oh	476	22	health	health	NN
cord-304876-txaoz7oh	476	23	impacts	impact	NNS
cord-304876-txaoz7oh	476	24	attributed	attribute	VBN
cord-304876-txaoz7oh	476	25	to	to	IN
cord-304876-txaoz7oh	476	26	them	-PRON-	PRP
cord-304876-txaoz7oh	476	27	.	.	.
cord-304876-txaoz7oh	477	1	The	the	DT
cord-304876-txaoz7oh	477	2	approved	approve	VBN
cord-304876-txaoz7oh	477	3	drugs	drug	NNS
cord-304876-txaoz7oh	477	4	include	include	VBP
cord-304876-txaoz7oh	477	5	zanamivir	zanamivir	NNP
cord-304876-txaoz7oh	477	6	,	,	,
cord-304876-txaoz7oh	477	7	oseltamivir	oseltamivir	FW
cord-304876-txaoz7oh	477	8	,	,	,
cord-304876-txaoz7oh	477	9	peramivir	peramivir	NNP
cord-304876-txaoz7oh	477	10	,	,	,
cord-304876-txaoz7oh	477	11	and	and	CC
cord-304876-txaoz7oh	477	12	favipiravir	favipiravir	NNP
cord-304876-txaoz7oh	477	13	(	(	-LRB-
cord-304876-txaoz7oh	477	14	Japan	Japan	NNP
cord-304876-txaoz7oh	477	15	only	only	RB
cord-304876-txaoz7oh	477	16	)	)	-RRB-
cord-304876-txaoz7oh	477	17	for	for	IN
cord-304876-txaoz7oh	477	18	influenza	influenza	NN
cord-304876-txaoz7oh	477	19	virus	virus	NN
cord-304876-txaoz7oh	477	20	and	and	CC
cord-304876-txaoz7oh	477	21	palivizumab	palivizumab	NNS
cord-304876-txaoz7oh	477	22	for	for	IN
cord-304876-txaoz7oh	477	23	RSV	RSV	NNP
cord-304876-txaoz7oh	477	24	,	,	,
cord-304876-txaoz7oh	477	25	all	all	DT
cord-304876-txaoz7oh	477	26	of	of	IN
cord-304876-txaoz7oh	477	27	which	which	WDT
cord-304876-txaoz7oh	477	28	have	have	VBP
cord-304876-txaoz7oh	477	29	limitations	limitation	NNS
cord-304876-txaoz7oh	477	30	that	that	WDT
cord-304876-txaoz7oh	477	31	prevent	prevent	VBP
cord-304876-txaoz7oh	477	32	their	-PRON-	PRP$
cord-304876-txaoz7oh	477	33	widespread	widespread	JJ
cord-304876-txaoz7oh	477	34	use	use	NN
cord-304876-txaoz7oh	477	35	in	in	IN
cord-304876-txaoz7oh	477	36	a	a	DT
cord-304876-txaoz7oh	477	37	therapeutic	therapeutic	JJ
cord-304876-txaoz7oh	477	38	setting	setting	NN
cord-304876-txaoz7oh	477	39	.	.	.
cord-304876-txaoz7oh	478	1	Drug	drug	NN
cord-304876-txaoz7oh	478	2	candidates	candidate	NNS
cord-304876-txaoz7oh	478	3	intended	intend	VBN
cord-304876-txaoz7oh	478	4	for	for	IN
cord-304876-txaoz7oh	478	5	use	use	NN
cord-304876-txaoz7oh	478	6	against	against	IN
cord-304876-txaoz7oh	478	7	rhinovirus	rhinovirus	NN
cord-304876-txaoz7oh	478	8	infections	infection	NNS
cord-304876-txaoz7oh	478	9	,	,	,
cord-304876-txaoz7oh	478	10	such	such	JJ
cord-304876-txaoz7oh	478	11	as	as	IN
cord-304876-txaoz7oh	478	12	the	the	DT
cord-304876-txaoz7oh	478	13	capsid	capsid	JJ
cord-304876-txaoz7oh	478	14	inhibitor	inhibitor	NN
cord-304876-txaoz7oh	478	15	pleconaril	pleconaril	NN
cord-304876-txaoz7oh	478	16	and	and	CC
cord-304876-txaoz7oh	478	17	the	the	DT
cord-304876-txaoz7oh	478	18	protease	protease	NN
cord-304876-txaoz7oh	478	19	inhibitor	inhibitor	NN
cord-304876-txaoz7oh	478	20	rupintrivir	rupintrivir	NNS
cord-304876-txaoz7oh	478	21	,	,	,
cord-304876-txaoz7oh	478	22	have	have	VBP
cord-304876-txaoz7oh	478	23	been	be	VBN
cord-304876-txaoz7oh	478	24	tested	test	VBN
cord-304876-txaoz7oh	478	25	in	in	IN
cord-304876-txaoz7oh	478	26	the	the	DT
cord-304876-txaoz7oh	478	27	clinic	clinic	NN
cord-304876-txaoz7oh	478	28	without	without	IN
cord-304876-txaoz7oh	478	29	success	success	NN
cord-304876-txaoz7oh	478	30	.	.	.
cord-304876-txaoz7oh	479	1	The	the	DT
cord-304876-txaoz7oh	479	2	first	first	JJ
cord-304876-txaoz7oh	479	3	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	479	4	analog	analog	NN
cord-304876-txaoz7oh	479	5	developed	develop	VBN
cord-304876-txaoz7oh	479	6	for	for	IN
cord-304876-txaoz7oh	479	7	respiratory	respiratory	JJ
cord-304876-txaoz7oh	479	8	viral	viral	JJ
cord-304876-txaoz7oh	479	9	infection	infection	NN
cord-304876-txaoz7oh	479	10	was	be	VBD
cord-304876-txaoz7oh	479	11	ribavirin	ribavirin	JJ
cord-304876-txaoz7oh	479	12	,	,	,
cord-304876-txaoz7oh	479	13	but	but	CC
cord-304876-txaoz7oh	479	14	despite	despite	IN
cord-304876-txaoz7oh	479	15	its	-PRON-	PRP$
cord-304876-txaoz7oh	479	16	approval	approval	NN
cord-304876-txaoz7oh	479	17	for	for	IN
cord-304876-txaoz7oh	479	18	use	use	NN
cord-304876-txaoz7oh	479	19	in	in	IN
cord-304876-txaoz7oh	479	20	RSV	RSV	NNP
cord-304876-txaoz7oh	479	21	,	,	,
cord-304876-txaoz7oh	479	22	its	-PRON-	PRP$
cord-304876-txaoz7oh	479	23	utility	utility	NN
cord-304876-txaoz7oh	479	24	for	for	IN
cord-304876-txaoz7oh	479	25	treating	treat	VBG
cord-304876-txaoz7oh	479	26	severe	severe	JJ
cord-304876-txaoz7oh	479	27	viral	viral	JJ
cord-304876-txaoz7oh	479	28	infections	infection	NNS
cord-304876-txaoz7oh	479	29	remains	remain	VBZ
cord-304876-txaoz7oh	479	30	low	low	JJ
cord-304876-txaoz7oh	479	31	.	.	.
cord-304876-txaoz7oh	480	1	Therefore	therefore	RB
cord-304876-txaoz7oh	480	2	,	,	,
cord-304876-txaoz7oh	480	3	the	the	DT
cord-304876-txaoz7oh	480	4	concept	concept	NN
cord-304876-txaoz7oh	480	5	of	of	IN
cord-304876-txaoz7oh	480	6	nucleoside	nucleoside	JJ
cord-304876-txaoz7oh	480	7	analogs	analog	NNS
cord-304876-txaoz7oh	480	8	against	against	IN
cord-304876-txaoz7oh	480	9	respiratory	respiratory	JJ
cord-304876-txaoz7oh	480	10	viruses	virus	NNS
cord-304876-txaoz7oh	480	11	remains	remain	VBZ
cord-304876-txaoz7oh	480	12	relatively	relatively	RB
cord-304876-txaoz7oh	480	13	new	new	JJ
cord-304876-txaoz7oh	480	14	and	and	CC
cord-304876-txaoz7oh	480	15	needs	need	VBZ
cord-304876-txaoz7oh	480	16	to	to	TO
cord-304876-txaoz7oh	480	17	be	be	VB
cord-304876-txaoz7oh	480	18	further	further	RB
cord-304876-txaoz7oh	480	19	explored	explore	VBN
cord-304876-txaoz7oh	480	20	.	.	.
cord-304876-txaoz7oh	481	1	What	what	WP
cord-304876-txaoz7oh	481	2	are	be	VBP
cord-304876-txaoz7oh	481	3	the	the	DT
cord-304876-txaoz7oh	481	4	molecular	molecular	JJ
cord-304876-txaoz7oh	481	5	determinants	determinant	NNS
cord-304876-txaoz7oh	481	6	of	of	IN
cord-304876-txaoz7oh	481	7	polymerase	polymerase	NN
cord-304876-txaoz7oh	481	8	selectivity	selectivity	NN
cord-304876-txaoz7oh	481	9	against	against	IN
cord-304876-txaoz7oh	481	10	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	481	11	analogs	analog	NNS
cord-304876-txaoz7oh	481	12	?	?	.
cord-304876-txaoz7oh	482	1	We	-PRON-	PRP
cord-304876-txaoz7oh	482	2	currently	currently	RB
cord-304876-txaoz7oh	482	3	do	do	VBP
cord-304876-txaoz7oh	482	4	not	not	RB
cord-304876-txaoz7oh	482	5	understand	understand	VB
cord-304876-txaoz7oh	482	6	well	well	RB
cord-304876-txaoz7oh	482	7	how	how	WRB
cord-304876-txaoz7oh	482	8	specific	specific	JJ
cord-304876-txaoz7oh	482	9	changes	change	NNS
cord-304876-txaoz7oh	482	10	made	make	VBN
cord-304876-txaoz7oh	482	11	in	in	IN
cord-304876-txaoz7oh	482	12	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	482	13	analogs	analog	NNS
cord-304876-txaoz7oh	482	14	alter	alter	VBP
cord-304876-txaoz7oh	482	15	their	-PRON-	PRP$
cord-304876-txaoz7oh	482	16	recognition	recognition	NN
cord-304876-txaoz7oh	482	17	as	as	IN
cord-304876-txaoz7oh	482	18	substrates	substrate	NNS
cord-304876-txaoz7oh	482	19	for	for	IN
cord-304876-txaoz7oh	482	20	RNA	RNA	NNP
cord-304876-txaoz7oh	482	21	synthesis	synthesis	NN
cord-304876-txaoz7oh	482	22	,	,	,
cord-304876-txaoz7oh	482	23	and	and	CC
cord-304876-txaoz7oh	482	24	how	how	WRB
cord-304876-txaoz7oh	482	25	substrate	substrate	NN
cord-304876-txaoz7oh	482	26	selectivity	selectivity	NN
cord-304876-txaoz7oh	482	27	differs	differ	VBZ
cord-304876-txaoz7oh	482	28	among	among	IN
cord-304876-txaoz7oh	482	29	positive	positive	JJ
cord-304876-txaoz7oh	482	30	and	and	CC
cord-304876-txaoz7oh	482	31	negative	negative	JJ
cord-304876-txaoz7oh	482	32	strand	strand	NN
cord-304876-txaoz7oh	482	33	RNA	RNA	NNP
cord-304876-txaoz7oh	482	34	virus	virus	NN
cord-304876-txaoz7oh	482	35	polymerases	polymerase	NNS
cord-304876-txaoz7oh	482	36	.	.	.
cord-304876-txaoz7oh	483	1	For	for	IN
cord-304876-txaoz7oh	483	2	example	example	NN
cord-304876-txaoz7oh	483	3	,	,	,
cord-304876-txaoz7oh	483	4	many	many	JJ
cord-304876-txaoz7oh	483	5	2	2	CD
cord-304876-txaoz7oh	483	6	0	0	CD
cord-304876-txaoz7oh	483	7	-modified	-modifie	VBN
cord-304876-txaoz7oh	483	8	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	483	9	analogs	analog	NNS
cord-304876-txaoz7oh	483	10	are	be	VBP
cord-304876-txaoz7oh	483	11	known	know	VBN
cord-304876-txaoz7oh	483	12	to	to	TO
cord-304876-txaoz7oh	483	13	inhibit	inhibit	VB
cord-304876-txaoz7oh	483	14	HCV	HCV	NNP
cord-304876-txaoz7oh	483	15	polymerase	polymerase	NN
cord-304876-txaoz7oh	483	16	,	,	,
cord-304876-txaoz7oh	483	17	often	often	RB
cord-304876-txaoz7oh	483	18	with	with	IN
cord-304876-txaoz7oh	483	19	an	an	DT
cord-304876-txaoz7oh	483	20	antiviral	antiviral	JJ
cord-304876-txaoz7oh	483	21	spectrum	spectrum	NN
cord-304876-txaoz7oh	483	22	extended	extend	VBN
cord-304876-txaoz7oh	483	23	to	to	IN
cord-304876-txaoz7oh	483	24	flaviviruses	flavivirus	NNS
cord-304876-txaoz7oh	483	25	and	and	CC
cord-304876-txaoz7oh	483	26	picornaviruses	picornavirus	NNS
cord-304876-txaoz7oh	483	27	.	.	.
cord-304876-txaoz7oh	484	1	However	however	RB
cord-304876-txaoz7oh	484	2	,	,	,
cord-304876-txaoz7oh	484	3	there	there	EX
cord-304876-txaoz7oh	484	4	is	be	VBZ
cord-304876-txaoz7oh	484	5	no	no	DT
cord-304876-txaoz7oh	484	6	clear	clear	JJ
cord-304876-txaoz7oh	484	7	mechanistic	mechanistic	JJ
cord-304876-txaoz7oh	484	8	basis	basis	NN
cord-304876-txaoz7oh	484	9	to	to	TO
cord-304876-txaoz7oh	484	10	explain	explain	VB
cord-304876-txaoz7oh	484	11	why	why	WRB
cord-304876-txaoz7oh	484	12	none	none	NN
cord-304876-txaoz7oh	484	13	of	of	IN
cord-304876-txaoz7oh	484	14	these	these	DT
cord-304876-txaoz7oh	484	15	compounds	compound	NNS
cord-304876-txaoz7oh	484	16	inhibit	inhibit	VBP
cord-304876-txaoz7oh	484	17	(	(	-LRB-
cord-304876-txaoz7oh	484	18	-)ssRNA	-)ssRNA	NNS
cord-304876-txaoz7oh	484	19	viruses	virus	NNS
cord-304876-txaoz7oh	484	20	,	,	,
cord-304876-txaoz7oh	484	21	or	or	CC
cord-304876-txaoz7oh	484	22	even	even	RB
cord-304876-txaoz7oh	484	23	other	other	JJ
cord-304876-txaoz7oh	484	24	(	(	-LRB-
cord-304876-txaoz7oh	484	25	þ)ssRNA	þ)ssrna	NN
cord-304876-txaoz7oh	484	26	viruses	virus	NNS
cord-304876-txaoz7oh	484	27	such	such	JJ
cord-304876-txaoz7oh	484	28	as	as	IN
cord-304876-txaoz7oh	484	29	CoV.	CoV.	NNP
cord-304876-txaoz7oh	485	1	Could	Could	MD
cord-304876-txaoz7oh	485	2	the	the	DT
cord-304876-txaoz7oh	485	3	exonuclease	exonuclease	NN
cord-304876-txaoz7oh	485	4	/	/	SYM
cord-304876-txaoz7oh	485	5	proofreading	proofreading	NN
cord-304876-txaoz7oh	485	6	activity	activity	NN
cord-304876-txaoz7oh	485	7	of	of	IN
cord-304876-txaoz7oh	485	8	CoV	cov	NN
cord-304876-txaoz7oh	485	9	polymerases	polymerase	NNS
cord-304876-txaoz7oh	485	10	excise	excise	VBP
cord-304876-txaoz7oh	485	11	chain	chain	NN
cord-304876-txaoz7oh	485	12	terminators	terminator	NNS
cord-304876-txaoz7oh	485	13	and	and	CC
cord-304876-txaoz7oh	485	14	resume	resume	VB
cord-304876-txaoz7oh	485	15	RNA	RNA	NNP
cord-304876-txaoz7oh	485	16	synthesis	synthesis	NN
cord-304876-txaoz7oh	485	17	?	?	.
cord-304876-txaoz7oh	486	1	Are	be	VBP
cord-304876-txaoz7oh	486	2	there	there	EX
cord-304876-txaoz7oh	486	3	specific	specific	JJ
cord-304876-txaoz7oh	486	4	amino	amino	NN
cord-304876-txaoz7oh	486	5	acid	acid	NN
cord-304876-txaoz7oh	486	6	within	within	IN
cord-304876-txaoz7oh	486	7	the	the	DT
cord-304876-txaoz7oh	486	8	active	active	JJ
cord-304876-txaoz7oh	486	9	site	site	NN
cord-304876-txaoz7oh	486	10	of	of	IN
cord-304876-txaoz7oh	486	11	(	(	-LRB-
cord-304876-txaoz7oh	486	12	-)ssRNA	-)ssRNA	NNP
cord-304876-txaoz7oh	486	13	virus	virus	NN
cord-304876-txaoz7oh	486	14	polymerases	polymerase	NNS
cord-304876-txaoz7oh	486	15	responsible	responsible	JJ
cord-304876-txaoz7oh	486	16	for	for	IN
cord-304876-txaoz7oh	486	17	the	the	DT
cord-304876-txaoz7oh	486	18	discrimination	discrimination	NN
cord-304876-txaoz7oh	486	19	of	of	IN
cord-304876-txaoz7oh	486	20	2	2	CD
cord-304876-txaoz7oh	486	21	0	0	CD
cord-304876-txaoz7oh	486	22	-C	-c	ADD
cord-304876-txaoz7oh	486	23	-	-	:
cord-304876-txaoz7oh	486	24	methyl	methyl	NN
cord-304876-txaoz7oh	486	25	nucleotides	nucleotide	NNS
cord-304876-txaoz7oh	486	26	?	?	.
cord-304876-txaoz7oh	487	1	These	these	DT
cord-304876-txaoz7oh	487	2	hypotheses	hypothesis	NNS
cord-304876-txaoz7oh	487	3	have	have	VBP
cord-304876-txaoz7oh	487	4	not	not	RB
cord-304876-txaoz7oh	487	5	been	be	VBN
cord-304876-txaoz7oh	487	6	tested	test	VBN
cord-304876-txaoz7oh	487	7	,	,	,
cord-304876-txaoz7oh	487	8	in	in	IN
cord-304876-txaoz7oh	487	9	part	part	NN
cord-304876-txaoz7oh	487	10	,	,	,
cord-304876-txaoz7oh	487	11	due	due	IN
cord-304876-txaoz7oh	487	12	to	to	IN
cord-304876-txaoz7oh	487	13	the	the	DT
cord-304876-txaoz7oh	487	14	difficulty	difficulty	NN
cord-304876-txaoz7oh	487	15	to	to	TO
cord-304876-txaoz7oh	487	16	conduct	conduct	VB
cord-304876-txaoz7oh	487	17	biochemical	biochemical	JJ
cord-304876-txaoz7oh	487	18	and	and	CC
cord-304876-txaoz7oh	487	19	structural	structural	JJ
cord-304876-txaoz7oh	487	20	studies	study	NNS
cord-304876-txaoz7oh	487	21	on	on	IN
cord-304876-txaoz7oh	487	22	viral	viral	JJ
cord-304876-txaoz7oh	487	23	polymerases	polymerase	NNS
cord-304876-txaoz7oh	487	24	from	from	IN
cord-304876-txaoz7oh	487	25	respiratory	respiratory	JJ
cord-304876-txaoz7oh	487	26	viruses	virus	NNS
cord-304876-txaoz7oh	487	27	.	.	.
cord-304876-txaoz7oh	488	1	Until	until	IN
cord-304876-txaoz7oh	488	2	recently	recently	RB
cord-304876-txaoz7oh	488	3	,	,	,
cord-304876-txaoz7oh	488	4	the	the	DT
cord-304876-txaoz7oh	488	5	production	production	NN
cord-304876-txaoz7oh	488	6	of	of	IN
cord-304876-txaoz7oh	488	7	soluble	soluble	JJ
cord-304876-txaoz7oh	488	8	,	,	,
cord-304876-txaoz7oh	488	9	pure	pure	JJ
cord-304876-txaoz7oh	488	10	viral	viral	JJ
cord-304876-txaoz7oh	488	11	protein	protein	NN
cord-304876-txaoz7oh	488	12	targets	target	NNS
cord-304876-txaoz7oh	488	13	has	have	VBZ
cord-304876-txaoz7oh	488	14	been	be	VBN
cord-304876-txaoz7oh	488	15	limiting	limit	VBG
cord-304876-txaoz7oh	488	16	,	,	,
cord-304876-txaoz7oh	488	17	especially	especially	RB
cord-304876-txaoz7oh	488	18	in	in	IN
cord-304876-txaoz7oh	488	19	the	the	DT
cord-304876-txaoz7oh	488	20	case	case	NN
cord-304876-txaoz7oh	488	21	of	of	IN
cord-304876-txaoz7oh	488	22	large	large	JJ
cord-304876-txaoz7oh	488	23	protein	protein	NN
cord-304876-txaoz7oh	488	24	complexes	complex	NNS
cord-304876-txaoz7oh	488	25	.	.	.
cord-304876-txaoz7oh	489	1	As	as	IN
cord-304876-txaoz7oh	489	2	mentioned	mention	VBN
cord-304876-txaoz7oh	489	3	earlier	early	RBR
cord-304876-txaoz7oh	489	4	in	in	IN
cord-304876-txaoz7oh	489	5	this	this	DT
cord-304876-txaoz7oh	489	6	review	review	NN
cord-304876-txaoz7oh	489	7	,	,	,
cord-304876-txaoz7oh	489	8	the	the	DT
cord-304876-txaoz7oh	489	9	development	development	NN
cord-304876-txaoz7oh	489	10	of	of	IN
cord-304876-txaoz7oh	489	11	robust	robust	JJ
cord-304876-txaoz7oh	489	12	expression	expression	NN
cord-304876-txaoz7oh	489	13	systems	system	NNS
cord-304876-txaoz7oh	489	14	for	for	IN
cord-304876-txaoz7oh	489	15	influenza	influenza	NN
cord-304876-txaoz7oh	489	16	polymerase	polymerase	NN
cord-304876-txaoz7oh	489	17	trimer	trimer	NN
cord-304876-txaoz7oh	489	18	,	,	,
cord-304876-txaoz7oh	489	19	as	as	IN
cord-304876-txaoz7oh	489	20	an	an	DT
cord-304876-txaoz7oh	489	21	example	example	NN
cord-304876-txaoz7oh	489	22	,	,	,
cord-304876-txaoz7oh	489	23	have	have	VBP
cord-304876-txaoz7oh	489	24	made	make	VBN
cord-304876-txaoz7oh	489	25	it	-PRON-	PRP
cord-304876-txaoz7oh	489	26	possible	possible	JJ
cord-304876-txaoz7oh	489	27	to	to	TO
cord-304876-txaoz7oh	489	28	use	use	VB
cord-304876-txaoz7oh	489	29	X	x	NN
cord-304876-txaoz7oh	489	30	-	-	NN
cord-304876-txaoz7oh	489	31	ray	ray	NN
cord-304876-txaoz7oh	489	32	crystallography	crystallography	NN
cord-304876-txaoz7oh	489	33	and	and	CC
cord-304876-txaoz7oh	489	34	potentially	potentially	RB
cord-304876-txaoz7oh	489	35	cryo	cryo	NN
cord-304876-txaoz7oh	489	36	-	-	HYPH
cord-304876-txaoz7oh	489	37	electron	electron	NN
cord-304876-txaoz7oh	489	38	microscopy	microscopy	NN
cord-304876-txaoz7oh	489	39	to	to	TO
cord-304876-txaoz7oh	489	40	provide	provide	VB
cord-304876-txaoz7oh	489	41	molecular	molecular	JJ
cord-304876-txaoz7oh	489	42	visualization	visualization	NN
cord-304876-txaoz7oh	489	43	of	of	IN
cord-304876-txaoz7oh	489	44	binding	bind	VBG
cord-304876-txaoz7oh	489	45	pockets	pocket	NNS
cord-304876-txaoz7oh	489	46	for	for	IN
cord-304876-txaoz7oh	489	47	small	small	JJ
cord-304876-txaoz7oh	489	48	molecule	molecule	NN
cord-304876-txaoz7oh	489	49	inhibitors	inhibitor	NNS
cord-304876-txaoz7oh	489	50	,	,	,
cord-304876-txaoz7oh	489	51	entry	entry	NN
cord-304876-txaoz7oh	489	52	and	and	CC
cord-304876-txaoz7oh	489	53	exit	exit	NN
cord-304876-txaoz7oh	489	54	channels	channel	NNS
cord-304876-txaoz7oh	489	55	for	for	IN
cord-304876-txaoz7oh	489	56	substrate(s	substrate(s	NNP
cord-304876-txaoz7oh	489	57	)	)	-RRB-
cord-304876-txaoz7oh	489	58	,	,	,
cord-304876-txaoz7oh	489	59	and	and	CC
cord-304876-txaoz7oh	489	60	potential	potential	JJ
cord-304876-txaoz7oh	489	61	new	new	JJ
cord-304876-txaoz7oh	489	62	ways	way	NNS
cord-304876-txaoz7oh	489	63	to	to	TO
cord-304876-txaoz7oh	489	64	disrupt	disrupt	VB
cord-304876-txaoz7oh	489	65	domain	domain	NN
cord-304876-txaoz7oh	489	66	interactions	interaction	NNS
cord-304876-txaoz7oh	489	67	.	.	.
cord-304876-txaoz7oh	490	1	These	these	DT
cord-304876-txaoz7oh	490	2	structural	structural	JJ
cord-304876-txaoz7oh	490	3	insights	insight	NNS
cord-304876-txaoz7oh	490	4	will	will	MD
cord-304876-txaoz7oh	490	5	tremendously	tremendously	RB
cord-304876-txaoz7oh	490	6	aid	aid	VB
cord-304876-txaoz7oh	490	7	the	the	DT
cord-304876-txaoz7oh	490	8	development	development	NN
cord-304876-txaoz7oh	490	9	of	of	IN
cord-304876-txaoz7oh	490	10	new	new	JJ
cord-304876-txaoz7oh	490	11	drugs	drug	NNS
cord-304876-txaoz7oh	490	12	as	as	RB
cord-304876-txaoz7oh	490	13	well	well	RB
cord-304876-txaoz7oh	490	14	as	as	IN
cord-304876-txaoz7oh	490	15	to	to	TO
cord-304876-txaoz7oh	490	16	further	further	RB
cord-304876-txaoz7oh	490	17	elucidate	elucidate	VB
cord-304876-txaoz7oh	490	18	the	the	DT
cord-304876-txaoz7oh	490	19	mechanisms	mechanism	NNS
cord-304876-txaoz7oh	490	20	of	of	IN
cord-304876-txaoz7oh	490	21	action	action	NN
cord-304876-txaoz7oh	490	22	and	and	CC
cord-304876-txaoz7oh	490	23	binding	binding	NN
cord-304876-txaoz7oh	490	24	of	of	IN
cord-304876-txaoz7oh	490	25	existing	exist	VBG
cord-304876-txaoz7oh	490	26	drugs	drug	NNS
cord-304876-txaoz7oh	490	27	to	to	IN
cord-304876-txaoz7oh	490	28	their	-PRON-	PRP$
cord-304876-txaoz7oh	490	29	protein	protein	NN
cord-304876-txaoz7oh	490	30	targets	target	NNS
cord-304876-txaoz7oh	490	31	.	.	.
cord-304876-txaoz7oh	491	1	Molecular	molecular	JJ
cord-304876-txaoz7oh	491	2	modeling	modeling	NN
cord-304876-txaoz7oh	491	3	is	be	VBZ
cord-304876-txaoz7oh	491	4	also	also	RB
cord-304876-txaoz7oh	491	5	a	a	DT
cord-304876-txaoz7oh	491	6	useful	useful	JJ
cord-304876-txaoz7oh	491	7	approach	approach	NN
cord-304876-txaoz7oh	491	8	that	that	IN
cord-304876-txaoz7oh	491	9	we	-PRON-	PRP
cord-304876-txaoz7oh	491	10	and	and	CC
cord-304876-txaoz7oh	491	11	others	other	NNS
cord-304876-txaoz7oh	491	12	have	have	VBP
cord-304876-txaoz7oh	491	13	used	use	VBN
cord-304876-txaoz7oh	491	14	to	to	TO
cord-304876-txaoz7oh	491	15	rationalize	rationalize	VB
cord-304876-txaoz7oh	491	16	the	the	DT
cord-304876-txaoz7oh	491	17	differences	difference	NNS
cord-304876-txaoz7oh	491	18	in	in	IN
cord-304876-txaoz7oh	491	19	selectivity	selectivity	NN
cord-304876-txaoz7oh	491	20	of	of	IN
cord-304876-txaoz7oh	491	21	lumicitabine	lumicitabine	NN
cord-304876-txaoz7oh	491	22	against	against	IN
cord-304876-txaoz7oh	491	23	RSV	RSV	NNP
cord-304876-txaoz7oh	491	24	and	and	CC
cord-304876-txaoz7oh	491	25	HCV	HCV	NNP
cord-304876-txaoz7oh	491	26	polymerase	polymerase	NN
cord-304876-txaoz7oh	491	27	.	.	.
cord-304876-txaoz7oh	492	1	159	159	CD
cord-304876-txaoz7oh	492	2	More	More	JJR
cord-304876-txaoz7oh	492	3	studies	study	NNS
cord-304876-txaoz7oh	492	4	such	such	JJ
cord-304876-txaoz7oh	492	5	as	as	IN
cord-304876-txaoz7oh	492	6	these	these	DT
cord-304876-txaoz7oh	492	7	ones	one	NNS
cord-304876-txaoz7oh	492	8	will	will	MD
cord-304876-txaoz7oh	492	9	be	be	VB
cord-304876-txaoz7oh	492	10	needed	need	VBN
cord-304876-txaoz7oh	492	11	to	to	TO
cord-304876-txaoz7oh	492	12	rationally	rationally	RB
cord-304876-txaoz7oh	492	13	design	design	VB
cord-304876-txaoz7oh	492	14	new	new	JJ
cord-304876-txaoz7oh	492	15	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	492	16	analogs	analog	NNS
cord-304876-txaoz7oh	492	17	targeting	target	VBG
cord-304876-txaoz7oh	492	18	respiratory	respiratory	JJ
cord-304876-txaoz7oh	492	19	virus	virus	NN
cord-304876-txaoz7oh	492	20	polymerases	polymerase	NNS
cord-304876-txaoz7oh	492	21	.	.	.
cord-304876-txaoz7oh	493	1	In	in	IN
cord-304876-txaoz7oh	493	2	the	the	DT
cord-304876-txaoz7oh	493	3	past	past	NN
cord-304876-txaoz7oh	493	4	,	,	,
cord-304876-txaoz7oh	493	5	many	many	JJ
cord-304876-txaoz7oh	493	6	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	493	7	analogs	analog	NNS
cord-304876-txaoz7oh	493	8	failed	fail	VBD
cord-304876-txaoz7oh	493	9	during	during	IN
cord-304876-txaoz7oh	493	10	development	development	NN
cord-304876-txaoz7oh	493	11	for	for	IN
cord-304876-txaoz7oh	493	12	safety	safety	NN
cord-304876-txaoz7oh	493	13	/	/	SYM
cord-304876-txaoz7oh	493	14	toxicity	toxicity	NN
cord-304876-txaoz7oh	493	15	reasons	reason	NNS
cord-304876-txaoz7oh	493	16	,	,	,
cord-304876-txaoz7oh	493	17	especially	especially	RB
cord-304876-txaoz7oh	493	18	molecules	molecule	NNS
cord-304876-txaoz7oh	493	19	with	with	IN
cord-304876-txaoz7oh	493	20	suboptimal	suboptimal	JJ
cord-304876-txaoz7oh	493	21	specificity	specificity	NN
cord-304876-txaoz7oh	493	22	for	for	IN
cord-304876-txaoz7oh	493	23	their	-PRON-	PRP$
cord-304876-txaoz7oh	493	24	viral	viral	JJ
cord-304876-txaoz7oh	493	25	polymerase	polymerase	NN
cord-304876-txaoz7oh	493	26	target	target	NN
cord-304876-txaoz7oh	493	27	and	and	CC
cord-304876-txaoz7oh	493	28	those	those	DT
cord-304876-txaoz7oh	493	29	used	use	VBN
cord-304876-txaoz7oh	493	30	for	for	IN
cord-304876-txaoz7oh	493	31	chronic	chronic	JJ
cord-304876-txaoz7oh	493	32	treatment	treatment	NN
cord-304876-txaoz7oh	493	33	of	of	IN
cord-304876-txaoz7oh	493	34	infections	infection	NNS
cord-304876-txaoz7oh	493	35	such	such	JJ
cord-304876-txaoz7oh	493	36	as	as	IN
cord-304876-txaoz7oh	493	37	HIV	HIV	NNP
cord-304876-txaoz7oh	493	38	and	and	CC
cord-304876-txaoz7oh	493	39	HCV	HCV	NNP
cord-304876-txaoz7oh	493	40	.	.	.
cord-304876-txaoz7oh	494	1	In	in	IN
cord-304876-txaoz7oh	494	2	the	the	DT
cord-304876-txaoz7oh	494	3	context	context	NN
cord-304876-txaoz7oh	494	4	of	of	IN
cord-304876-txaoz7oh	494	5	acute	acute	JJ
cord-304876-txaoz7oh	494	6	respiratory	respiratory	JJ
cord-304876-txaoz7oh	494	7	infections	infection	NNS
cord-304876-txaoz7oh	494	8	,	,	,
cord-304876-txaoz7oh	494	9	evaluation	evaluation	NN
cord-304876-txaoz7oh	494	10	of	of	IN
cord-304876-txaoz7oh	494	11	safety	safety	NN
cord-304876-txaoz7oh	494	12	must	must	MD
cord-304876-txaoz7oh	494	13	be	be	VB
cord-304876-txaoz7oh	494	14	based	base	VBN
cord-304876-txaoz7oh	494	15	on	on	IN
cord-304876-txaoz7oh	494	16	both	both	CC
cord-304876-txaoz7oh	494	17	the	the	DT
cord-304876-txaoz7oh	494	18	intended	intended	JJ
cord-304876-txaoz7oh	494	19	duration	duration	NN
cord-304876-txaoz7oh	494	20	of	of	IN
cord-304876-txaoz7oh	494	21	treatment	treatment	NN
cord-304876-txaoz7oh	494	22	and	and	CC
cord-304876-txaoz7oh	494	23	the	the	DT
cord-304876-txaoz7oh	494	24	targeted	target	VBN
cord-304876-txaoz7oh	494	25	patients	patient	NNS
cord-304876-txaoz7oh	494	26	,	,	,
cord-304876-txaoz7oh	494	27	which	which	WDT
cord-304876-txaoz7oh	494	28	sometimes	sometimes	RB
cord-304876-txaoz7oh	494	29	include	include	VBP
cord-304876-txaoz7oh	494	30	vulnerable	vulnerable	JJ
cord-304876-txaoz7oh	494	31	populations	population	NNS
cord-304876-txaoz7oh	494	32	such	such	JJ
cord-304876-txaoz7oh	494	33	as	as	IN
cord-304876-txaoz7oh	494	34	children	child	NNS
cord-304876-txaoz7oh	494	35	and	and	CC
cord-304876-txaoz7oh	494	36	the	the	DT
cord-304876-txaoz7oh	494	37	elderly	elderly	JJ
cord-304876-txaoz7oh	494	38	.	.	.
cord-304876-txaoz7oh	495	1	Other	other	JJ
cord-304876-txaoz7oh	495	2	considerations	consideration	NNS
cord-304876-txaoz7oh	495	3	to	to	TO
cord-304876-txaoz7oh	495	4	ensure	ensure	VB
cord-304876-txaoz7oh	495	5	successful	successful	JJ
cord-304876-txaoz7oh	495	6	future	future	JJ
cord-304876-txaoz7oh	495	7	development	development	NN
cord-304876-txaoz7oh	495	8	of	of	IN
cord-304876-txaoz7oh	495	9	nucleoside	nucleoside	JJ
cord-304876-txaoz7oh	495	10	analogs	analog	NNS
cord-304876-txaoz7oh	495	11	directed	direct	VBN
cord-304876-txaoz7oh	495	12	against	against	IN
cord-304876-txaoz7oh	495	13	respiratory	respiratory	JJ
cord-304876-txaoz7oh	495	14	infections	infection	NNS
cord-304876-txaoz7oh	495	15	will	will	MD
cord-304876-txaoz7oh	495	16	be	be	VB
cord-304876-txaoz7oh	495	17	to	to	TO
cord-304876-txaoz7oh	495	18	optimize	optimize	VB
cord-304876-txaoz7oh	495	19	delivery	delivery	NN
cord-304876-txaoz7oh	495	20	to	to	IN
cord-304876-txaoz7oh	495	21	the	the	DT
cord-304876-txaoz7oh	495	22	lung	lung	NN
cord-304876-txaoz7oh	495	23	by	by	IN
cord-304876-txaoz7oh	495	24	evaluating	evaluate	VBG
cord-304876-txaoz7oh	495	25	different	different	JJ
cord-304876-txaoz7oh	495	26	routes	route	NNS
cord-304876-txaoz7oh	495	27	of	of	IN
cord-304876-txaoz7oh	495	28	administrations	administration	NNS
cord-304876-txaoz7oh	495	29	,	,	,
cord-304876-txaoz7oh	495	30	including	include	VBG
cord-304876-txaoz7oh	495	31	aerosol	aerosol	NN
cord-304876-txaoz7oh	495	32	formulations	formulation	NNS
cord-304876-txaoz7oh	495	33	,	,	,
cord-304876-txaoz7oh	495	34	and	and	CC
cord-304876-txaoz7oh	495	35	developing	develop	VBG
cord-304876-txaoz7oh	495	36	lung	lung	NN
cord-304876-txaoz7oh	495	37	-	-	HYPH
cord-304876-txaoz7oh	495	38	targeting	target	VBG
cord-304876-txaoz7oh	495	39	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	495	40	prodrugs	prodrug	NNS
cord-304876-txaoz7oh	495	41	.	.	.
cord-304876-txaoz7oh	496	1	Despite	despite	IN
cord-304876-txaoz7oh	496	2	these	these	DT
cord-304876-txaoz7oh	496	3	challenges	challenge	NNS
cord-304876-txaoz7oh	496	4	,	,	,
cord-304876-txaoz7oh	496	5	the	the	DT
cord-304876-txaoz7oh	496	6	prospect	prospect	NN
cord-304876-txaoz7oh	496	7	of	of	IN
cord-304876-txaoz7oh	496	8	developing	develop	VBG
cord-304876-txaoz7oh	496	9	nucleoside	nucleoside	JJ
cord-304876-txaoz7oh	496	10	analogs	analog	NNS
cord-304876-txaoz7oh	496	11	directed	direct	VBN
cord-304876-txaoz7oh	496	12	against	against	IN
cord-304876-txaoz7oh	496	13	respiratory	respiratory	JJ
cord-304876-txaoz7oh	496	14	RNA	RNA	NNP
cord-304876-txaoz7oh	496	15	virus	virus	NN
cord-304876-txaoz7oh	496	16	infections	infection	NNS
cord-304876-txaoz7oh	496	17	represents	represent	VBZ
cord-304876-txaoz7oh	496	18	an	an	DT
cord-304876-txaoz7oh	496	19	exciting	exciting	JJ
cord-304876-txaoz7oh	496	20	new	new	JJ
cord-304876-txaoz7oh	496	21	avenue	avenue	NN
cord-304876-txaoz7oh	496	22	in	in	IN
cord-304876-txaoz7oh	496	23	antiviral	antiviral	JJ
cord-304876-txaoz7oh	496	24	research	research	NN
cord-304876-txaoz7oh	496	25	.	.	.
cord-304876-txaoz7oh	497	1	The	the	DT
cord-304876-txaoz7oh	497	2	global	global	JJ
cord-304876-txaoz7oh	497	3	burden	burden	NN
cord-304876-txaoz7oh	497	4	of	of	IN
cord-304876-txaoz7oh	497	5	respiratory	respiratory	JJ
cord-304876-txaoz7oh	497	6	disease	disease	NN
cord-304876-txaoz7oh	497	7	Structure	Structure	NNP
cord-304876-txaoz7oh	497	8	and	and	CC
cord-304876-txaoz7oh	497	9	classification	classification	NN
cord-304876-txaoz7oh	497	10	of	of	IN
cord-304876-txaoz7oh	497	11	viruses	virus	NNS
cord-304876-txaoz7oh	498	1	The	the	DT
cord-304876-txaoz7oh	498	2	classification	classification	NN
cord-304876-txaoz7oh	498	3	of	of	IN
cord-304876-txaoz7oh	498	4	viruses	virus	NNS
cord-304876-txaoz7oh	498	5	infecting	infect	VBG
cord-304876-txaoz7oh	498	6	the	the	DT
cord-304876-txaoz7oh	498	7	respiratory	respiratory	JJ
cord-304876-txaoz7oh	498	8	tract	tract	NN
cord-304876-txaoz7oh	498	9	Virus	virus	NN
cord-304876-txaoz7oh	498	10	detection	detection	NN
cord-304876-txaoz7oh	498	11	in	in	IN
cord-304876-txaoz7oh	498	12	critically	critically	RB
cord-304876-txaoz7oh	498	13	ill	ill	JJ
cord-304876-txaoz7oh	498	14	children	child	NNS
cord-304876-txaoz7oh	498	15	with	with	IN
cord-304876-txaoz7oh	498	16	acute	acute	JJ
cord-304876-txaoz7oh	498	17	respiratory	respiratory	JJ
cord-304876-txaoz7oh	498	18	disease	disease	NN
cord-304876-txaoz7oh	498	19	:	:	:
cord-304876-txaoz7oh	498	20	a	a	DT
cord-304876-txaoz7oh	498	21	new	new	JJ
cord-304876-txaoz7oh	498	22	profile	profile	NN
cord-304876-txaoz7oh	498	23	in	in	IN
cord-304876-txaoz7oh	498	24	view	view	NN
cord-304876-txaoz7oh	498	25	of	of	IN
cord-304876-txaoz7oh	498	26	new	new	JJ
cord-304876-txaoz7oh	498	27	technology	technology	NN
cord-304876-txaoz7oh	498	28	Influenza	Influenza	NNP
cord-304876-txaoz7oh	498	29	virus	virus	NN
cord-304876-txaoz7oh	498	30	RNA	rna	NN
cord-304876-txaoz7oh	498	31	polymerase	polymerase	NN
cord-304876-txaoz7oh	498	32	:	:	:
cord-304876-txaoz7oh	498	33	insights	insight	NNS
cord-304876-txaoz7oh	498	34	into	into	IN
cord-304876-txaoz7oh	498	35	the	the	DT
cord-304876-txaoz7oh	498	36	mechanisms	mechanism	NNS
cord-304876-txaoz7oh	498	37	of	of	IN
cord-304876-txaoz7oh	498	38	viral	viral	JJ
cord-304876-txaoz7oh	498	39	RNA	RNA	NNP
cord-304876-txaoz7oh	498	40	synthesis	synthesis	NN
cord-304876-txaoz7oh	498	41	Selective	selective	JJ
cord-304876-txaoz7oh	498	42	inactivation	inactivation	NN
cord-304876-txaoz7oh	498	43	of	of	IN
cord-304876-txaoz7oh	498	44	influenza	influenza	NN
cord-304876-txaoz7oh	498	45	C	C	NNP
cord-304876-txaoz7oh	498	46	esterase	esterase	NN
cord-304876-txaoz7oh	498	47	:	:	:
cord-304876-txaoz7oh	498	48	a	a	DT
cord-304876-txaoz7oh	498	49	probe	probe	NN
cord-304876-txaoz7oh	498	50	for	for	IN
cord-304876-txaoz7oh	498	51	detecting	detect	VBG
cord-304876-txaoz7oh	498	52	9-O	9-o	CD
cord-304876-txaoz7oh	498	53	-	-	HYPH
cord-304876-txaoz7oh	498	54	acetylated	acetylated	JJ
cord-304876-txaoz7oh	498	55	sialic	sialic	NN
cord-304876-txaoz7oh	498	56	acids	acid	NNS
cord-304876-txaoz7oh	499	1	An	an	DT
cord-304876-txaoz7oh	499	2	open	open	JJ
cord-304876-txaoz7oh	499	3	receptor	receptor	NN
cord-304876-txaoz7oh	499	4	-	-	HYPH
cord-304876-txaoz7oh	499	5	binding	bind	VBG
cord-304876-txaoz7oh	499	6	cavity	cavity	NN
cord-304876-txaoz7oh	499	7	of	of	IN
cord-304876-txaoz7oh	499	8	hemagglutinin	hemagglutinin	NN
cord-304876-txaoz7oh	499	9	-	-	HYPH
cord-304876-txaoz7oh	499	10	esterase	esterase	NN
cord-304876-txaoz7oh	499	11	-	-	HYPH
cord-304876-txaoz7oh	499	12	fusion	fusion	NN
cord-304876-txaoz7oh	499	13	glycoprotein	glycoprotein	NN
cord-304876-txaoz7oh	499	14	from	from	IN
cord-304876-txaoz7oh	499	15	newly	newly	RB
cord-304876-txaoz7oh	499	16	-	-	HYPH
cord-304876-txaoz7oh	499	17	identified	identify	VBN
cord-304876-txaoz7oh	499	18	influenza	influenza	NN
cord-304876-txaoz7oh	499	19	D	d	NN
cord-304876-txaoz7oh	499	20	virus	virus	NN
cord-304876-txaoz7oh	499	21	:	:	:
cord-304876-txaoz7oh	499	22	Basis	basis	NN
cord-304876-txaoz7oh	499	23	for	for	IN
cord-304876-txaoz7oh	499	24	its	-PRON-	PRP$
cord-304876-txaoz7oh	499	25	broad	broad	JJ
cord-304876-txaoz7oh	499	26	cell	cell	NN
cord-304876-txaoz7oh	499	27	tropism	tropism	NN
cord-304876-txaoz7oh	499	28	Clinical	clinical	JJ
cord-304876-txaoz7oh	499	29	review	review	NN
cord-304876-txaoz7oh	499	30	:	:	:
cord-304876-txaoz7oh	499	31	Primary	primary	JJ
cord-304876-txaoz7oh	499	32	influenza	influenza	NN
cord-304876-txaoz7oh	499	33	viral	viral	JJ
cord-304876-txaoz7oh	499	34	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	500	1	A	a	DT
cord-304876-txaoz7oh	500	2	narrative	narrative	NN
cord-304876-txaoz7oh	500	3	review	review	NN
cord-304876-txaoz7oh	500	4	of	of	IN
cord-304876-txaoz7oh	500	5	influenza	influenza	NN
cord-304876-txaoz7oh	500	6	:	:	:
cord-304876-txaoz7oh	500	7	A	a	DT
cord-304876-txaoz7oh	500	8	seasonal	seasonal	JJ
cord-304876-txaoz7oh	500	9	and	and	CC
cord-304876-txaoz7oh	500	10	pandemic	pandemic	NN
cord-304876-txaoz7oh	500	11	disease	disease	NN
cord-304876-txaoz7oh	500	12	Incidence	incidence	NN
cord-304876-txaoz7oh	500	13	of	of	IN
cord-304876-txaoz7oh	500	14	medically	medically	RB
cord-304876-txaoz7oh	500	15	attended	attend	VBN
cord-304876-txaoz7oh	500	16	influenza	influenza	NN
cord-304876-txaoz7oh	500	17	during	during	IN
cord-304876-txaoz7oh	500	18	pandemic	pandemic	NN
cord-304876-txaoz7oh	500	19	and	and	CC
cord-304876-txaoz7oh	500	20	postpandemic	postpandemic	NNP
cord-304876-txaoz7oh	500	21	seasons	season	NNS
cord-304876-txaoz7oh	500	22	through	through	IN
cord-304876-txaoz7oh	500	23	the	the	DT
cord-304876-txaoz7oh	500	24	Influenza	Influenza	NNP
cord-304876-txaoz7oh	500	25	Incidence	Incidence	NNP
cord-304876-txaoz7oh	500	26	Surveillance	Surveillance	NNP
cord-304876-txaoz7oh	500	27	Project	Project	NNP
cord-304876-txaoz7oh	501	1	A	a	DT
cord-304876-txaoz7oh	501	2	review	review	NN
cord-304876-txaoz7oh	501	3	of	of	IN
cord-304876-txaoz7oh	501	4	vaccine	vaccine	NN
cord-304876-txaoz7oh	501	5	research	research	NN
cord-304876-txaoz7oh	501	6	and	and	CC
cord-304876-txaoz7oh	501	7	development	development	NN
cord-304876-txaoz7oh	501	8	:	:	:
cord-304876-txaoz7oh	502	1	Human	human	JJ
cord-304876-txaoz7oh	502	2	acute	acute	JJ
cord-304876-txaoz7oh	502	3	respiratory	respiratory	JJ
cord-304876-txaoz7oh	502	4	infections	infection	NNS
cord-304876-txaoz7oh	502	5	Taxonomy	Taxonomy	NNP
cord-304876-txaoz7oh	502	6	of	of	IN
cord-304876-txaoz7oh	502	7	the	the	DT
cord-304876-txaoz7oh	502	8	order	order	NN
cord-304876-txaoz7oh	502	9	Mononegavirales	Mononegavirales	NNP
cord-304876-txaoz7oh	502	10	:	:	:
cord-304876-txaoz7oh	502	11	update	update	VB
cord-304876-txaoz7oh	502	12	2016	2016	CD
cord-304876-txaoz7oh	502	13	Respiratory	respiratory	JJ
cord-304876-txaoz7oh	502	14	syncytial	syncytial	JJ
cord-304876-txaoz7oh	502	15	virus	virus	NN
cord-304876-txaoz7oh	502	16	and	and	CC
cord-304876-txaoz7oh	502	17	parainfluenza	parainfluenza	NNP
cord-304876-txaoz7oh	502	18	virus	virus	NN
cord-304876-txaoz7oh	502	19	Pediatric	pediatric	JJ
cord-304876-txaoz7oh	502	20	hospitalizations	hospitalization	NNS
cord-304876-txaoz7oh	502	21	for	for	IN
cord-304876-txaoz7oh	502	22	croup	croup	NN
cord-304876-txaoz7oh	502	23	(	(	-LRB-
cord-304876-txaoz7oh	502	24	laryngotracheobronchitis	laryngotracheobronchitis	NNP
cord-304876-txaoz7oh	502	25	)	)	-RRB-
cord-304876-txaoz7oh	502	26	:	:	:
cord-304876-txaoz7oh	502	27	Biennial	biennial	JJ
cord-304876-txaoz7oh	502	28	increases	increase	NNS
cord-304876-txaoz7oh	502	29	associated	associate	VBN
cord-304876-txaoz7oh	502	30	with	with	IN
cord-304876-txaoz7oh	502	31	human	human	JJ
cord-304876-txaoz7oh	502	32	parainfluenza	parainfluenza	NNP
cord-304876-txaoz7oh	502	33	virus	virus	NN
cord-304876-txaoz7oh	502	34	1	1	CD
cord-304876-txaoz7oh	502	35	epidemics	epidemic	NNS
cord-304876-txaoz7oh	502	36	Glide	glide	VBP
cord-304876-txaoz7oh	502	37	:	:	:
cord-304876-txaoz7oh	502	38	a	a	DT
cord-304876-txaoz7oh	502	39	new	new	JJ
cord-304876-txaoz7oh	502	40	approach	approach	NN
cord-304876-txaoz7oh	502	41	for	for	IN
cord-304876-txaoz7oh	502	42	rapid	rapid	JJ
cord-304876-txaoz7oh	502	43	,	,	,
cord-304876-txaoz7oh	502	44	accurate	accurate	JJ
cord-304876-txaoz7oh	502	45	docking	docking	NN
cord-304876-txaoz7oh	502	46	and	and	CC
cord-304876-txaoz7oh	502	47	scoring	scoring	NN
cord-304876-txaoz7oh	502	48	.	.	.
cord-304876-txaoz7oh	503	1	1	1	LS
cord-304876-txaoz7oh	503	2	.	.	.
cord-304876-txaoz7oh	504	1	Method	method	NN
cord-304876-txaoz7oh	504	2	and	and	CC
cord-304876-txaoz7oh	504	3	assessment	assessment	NN
cord-304876-txaoz7oh	504	4	of	of	IN
cord-304876-txaoz7oh	504	5	docking	docking	NN
cord-304876-txaoz7oh	504	6	accuracy	accuracy	NN
cord-304876-txaoz7oh	504	7	Epidemiology	epidemiology	NN
cord-304876-txaoz7oh	504	8	and	and	CC
cord-304876-txaoz7oh	504	9	clinical	clinical	JJ
cord-304876-txaoz7oh	504	10	presentation	presentation	NN
cord-304876-txaoz7oh	504	11	of	of	IN
cord-304876-txaoz7oh	504	12	the	the	DT
cord-304876-txaoz7oh	504	13	four	four	CD
cord-304876-txaoz7oh	504	14	human	human	JJ
cord-304876-txaoz7oh	504	15	parainfluenza	parainfluenza	NNP
cord-304876-txaoz7oh	504	16	virus	virus	NN
cord-304876-txaoz7oh	504	17	types	types	NNP
cord-304876-txaoz7oh	504	18	Population	population	NN
cord-304876-txaoz7oh	504	19	-	-	HYPH
cord-304876-txaoz7oh	504	20	based	base	VBN
cord-304876-txaoz7oh	504	21	surveillance	surveillance	NN
cord-304876-txaoz7oh	504	22	for	for	IN
cord-304876-txaoz7oh	504	23	hospitalizations	hospitalization	NNS
cord-304876-txaoz7oh	504	24	associated	associate	VBN
cord-304876-txaoz7oh	504	25	with	with	IN
cord-304876-txaoz7oh	504	26	respiratory	respiratory	JJ
cord-304876-txaoz7oh	504	27	syncytial	syncytial	JJ
cord-304876-txaoz7oh	504	28	virus	virus	NN
cord-304876-txaoz7oh	504	29	,	,	,
cord-304876-txaoz7oh	504	30	influenza	influenza	NN
cord-304876-txaoz7oh	504	31	virus	virus	NN
cord-304876-txaoz7oh	504	32	,	,	,
cord-304876-txaoz7oh	504	33	and	and	CC
cord-304876-txaoz7oh	504	34	parainfluenza	parainfluenza	NN
cord-304876-txaoz7oh	504	35	viruses	virus	NNS
cord-304876-txaoz7oh	504	36	among	among	IN
cord-304876-txaoz7oh	504	37	young	young	JJ
cord-304876-txaoz7oh	504	38	children	child	NNS
cord-304876-txaoz7oh	504	39	Global	global	JJ
cord-304876-txaoz7oh	504	40	burden	burden	NN
cord-304876-txaoz7oh	504	41	of	of	IN
cord-304876-txaoz7oh	504	42	acute	acute	JJ
cord-304876-txaoz7oh	504	43	lower	low	JJR
cord-304876-txaoz7oh	504	44	respiratory	respiratory	JJ
cord-304876-txaoz7oh	504	45	infections	infection	NNS
cord-304876-txaoz7oh	504	46	due	due	JJ
cord-304876-txaoz7oh	504	47	to	to	IN
cord-304876-txaoz7oh	504	48	respiratory	respiratory	JJ
cord-304876-txaoz7oh	504	49	syncytial	syncytial	JJ
cord-304876-txaoz7oh	504	50	virus	virus	NN
cord-304876-txaoz7oh	504	51	in	in	IN
cord-304876-txaoz7oh	504	52	young	young	JJ
cord-304876-txaoz7oh	504	53	children	child	NNS
cord-304876-txaoz7oh	504	54	:	:	:
cord-304876-txaoz7oh	504	55	a	a	DT
cord-304876-txaoz7oh	504	56	systematic	systematic	JJ
cord-304876-txaoz7oh	504	57	review	review	NN
cord-304876-txaoz7oh	504	58	and	and	CC
cord-304876-txaoz7oh	504	59	meta	meta	NNP
cord-304876-txaoz7oh	504	60	-	-	HYPH
cord-304876-txaoz7oh	504	61	analysis	analysis	NN
cord-304876-txaoz7oh	504	62	Respiratory	respiratory	JJ
cord-304876-txaoz7oh	504	63	syncytial	syncytial	JJ
cord-304876-txaoz7oh	504	64	virus	virus	NN
cord-304876-txaoz7oh	504	65	,	,	,
cord-304876-txaoz7oh	504	66	an	an	DT
cord-304876-txaoz7oh	504	67	ongoing	ongoing	JJ
cord-304876-txaoz7oh	504	68	medical	medical	JJ
cord-304876-txaoz7oh	504	69	dilemma	dilemma	NN
cord-304876-txaoz7oh	504	70	:	:	:
cord-304876-txaoz7oh	504	71	an	an	DT
cord-304876-txaoz7oh	504	72	expert	expert	JJ
cord-304876-txaoz7oh	504	73	commentary	commentary	NN
cord-304876-txaoz7oh	504	74	on	on	IN
cord-304876-txaoz7oh	504	75	respiratory	respiratory	JJ
cord-304876-txaoz7oh	504	76	syncytial	syncytial	JJ
cord-304876-txaoz7oh	504	77	virus	virus	NN
cord-304876-txaoz7oh	504	78	prophylactic	prophylactic	JJ
cord-304876-txaoz7oh	504	79	and	and	CC
cord-304876-txaoz7oh	504	80	therapeutic	therapeutic	JJ
cord-304876-txaoz7oh	504	81	pharmaceuticals	pharmaceutical	NNS
cord-304876-txaoz7oh	504	82	currently	currently	RB
cord-304876-txaoz7oh	504	83	in	in	IN
cord-304876-txaoz7oh	504	84	clinical	clinical	JJ
cord-304876-txaoz7oh	504	85	trials	trial	NNS
cord-304876-txaoz7oh	505	1	The	the	DT
cord-304876-txaoz7oh	505	2	pathogenesis	pathogenesis	NN
cord-304876-txaoz7oh	505	3	of	of	IN
cord-304876-txaoz7oh	505	4	respiratory	respiratory	JJ
cord-304876-txaoz7oh	505	5	syncytial	syncytial	JJ
cord-304876-txaoz7oh	505	6	virus	virus	NN
cord-304876-txaoz7oh	505	7	disease	disease	NN
cord-304876-txaoz7oh	505	8	in	in	IN
cord-304876-txaoz7oh	505	9	childhood	childhood	NN
cord-304876-txaoz7oh	505	10	Respiratory	respiratory	JJ
cord-304876-txaoz7oh	505	11	syncytial	syncytial	JJ
cord-304876-txaoz7oh	505	12	virus	virus	NN
cord-304876-txaoz7oh	505	13	disease	disease	NN
cord-304876-txaoz7oh	505	14	:	:	:
cord-304876-txaoz7oh	505	15	update	update	VB
cord-304876-txaoz7oh	505	16	on	on	IN
cord-304876-txaoz7oh	505	17	treatment	treatment	NN
cord-304876-txaoz7oh	505	18	and	and	CC
cord-304876-txaoz7oh	505	19	prevention	prevention	NN
cord-304876-txaoz7oh	505	20	Human	Human	NNP
cord-304876-txaoz7oh	505	21	metapneumovirus	metapneumovirus	JJ
cord-304876-txaoz7oh	505	22	infection	infection	NN
cord-304876-txaoz7oh	505	23	in	in	IN
cord-304876-txaoz7oh	505	24	adults	adult	NNS
cord-304876-txaoz7oh	506	1	Human	Human	NNP
cord-304876-txaoz7oh	506	2	metapneumovirus	metapneumovirus	NNP
cord-304876-txaoz7oh	506	3	:	:	:
cord-304876-txaoz7oh	506	4	A	a	DT
cord-304876-txaoz7oh	506	5	new	new	JJ
cord-304876-txaoz7oh	506	6	player	player	NN
cord-304876-txaoz7oh	506	7	among	among	IN
cord-304876-txaoz7oh	506	8	respiratory	respiratory	JJ
cord-304876-txaoz7oh	506	9	viruses	virus	NNS
cord-304876-txaoz7oh	506	10	Human	human	JJ
cord-304876-txaoz7oh	506	11	metapneumovirus	metapneumovirus	NN
cord-304876-txaoz7oh	506	12	associated	associate	VBN
cord-304876-txaoz7oh	506	13	with	with	IN
cord-304876-txaoz7oh	506	14	respiratory	respiratory	JJ
cord-304876-txaoz7oh	506	15	tract	tract	NN
cord-304876-txaoz7oh	506	16	infections	infection	NNS
cord-304876-txaoz7oh	506	17	in	in	IN
cord-304876-txaoz7oh	506	18	a	a	DT
cord-304876-txaoz7oh	506	19	3-year	3-year	CD
cord-304876-txaoz7oh	506	20	study	study	NN
cord-304876-txaoz7oh	506	21	of	of	IN
cord-304876-txaoz7oh	506	22	nasal	nasal	NN
cord-304876-txaoz7oh	506	23	swabs	swab	NNS
cord-304876-txaoz7oh	506	24	from	from	IN
cord-304876-txaoz7oh	506	25	infants	infant	NNS
cord-304876-txaoz7oh	506	26	in	in	IN
cord-304876-txaoz7oh	506	27	Italy	Italy	NNP
cord-304876-txaoz7oh	506	28	Epidemiology	Epidemiology	NNP
cord-304876-txaoz7oh	506	29	,	,	,
cord-304876-txaoz7oh	506	30	pathogenesis	pathogenesis	NN
cord-304876-txaoz7oh	506	31	,	,	,
cord-304876-txaoz7oh	506	32	and	and	CC
cord-304876-txaoz7oh	506	33	treatment	treatment	NN
cord-304876-txaoz7oh	506	34	of	of	IN
cord-304876-txaoz7oh	506	35	the	the	DT
cord-304876-txaoz7oh	506	36	common	common	JJ
cord-304876-txaoz7oh	506	37	cold	cold	JJ
cord-304876-txaoz7oh	506	38	Picornavirus	Picornavirus	NNP
cord-304876-txaoz7oh	506	39	and	and	CC
cord-304876-txaoz7oh	506	40	enterovirus	enterovirus	NN
cord-304876-txaoz7oh	506	41	diversity	diversity	NN
cord-304876-txaoz7oh	506	42	with	with	IN
cord-304876-txaoz7oh	506	43	associated	associated	JJ
cord-304876-txaoz7oh	506	44	human	human	JJ
cord-304876-txaoz7oh	506	45	diseases	disease	NNS
cord-304876-txaoz7oh	506	46	Symptom	symptom	NN
cord-304876-txaoz7oh	506	47	profile	profile	NN
cord-304876-txaoz7oh	506	48	of	of	IN
cord-304876-txaoz7oh	506	49	common	common	JJ
cord-304876-txaoz7oh	506	50	colds	cold	NNS
cord-304876-txaoz7oh	506	51	in	in	IN
cord-304876-txaoz7oh	506	52	school	school	NN
cord-304876-txaoz7oh	506	53	-	-	HYPH
cord-304876-txaoz7oh	506	54	aged	age	VBN
cord-304876-txaoz7oh	506	55	children	child	NNS
cord-304876-txaoz7oh	506	56	Enterovirus	enteroviru	NNS
cord-304876-txaoz7oh	506	57	and	and	CC
cord-304876-txaoz7oh	506	58	parechovirus	parechovirus	JJ
cord-304876-txaoz7oh	506	59	infection	infection	NN
cord-304876-txaoz7oh	506	60	in	in	IN
cord-304876-txaoz7oh	506	61	children	child	NNS
cord-304876-txaoz7oh	506	62	:	:	:
cord-304876-txaoz7oh	506	63	a	a	DT
cord-304876-txaoz7oh	506	64	brief	brief	JJ
cord-304876-txaoz7oh	506	65	overview	overview	NN
cord-304876-txaoz7oh	506	66	Recombination	recombination	NN
cord-304876-txaoz7oh	506	67	in	in	IN
cord-304876-txaoz7oh	506	68	the	the	DT
cord-304876-txaoz7oh	506	69	evolution	evolution	NN
cord-304876-txaoz7oh	506	70	of	of	IN
cord-304876-txaoz7oh	506	71	enterovirus	enterovirus	NN
cord-304876-txaoz7oh	506	72	C	c	NN
cord-304876-txaoz7oh	506	73	species	species	NN
cord-304876-txaoz7oh	506	74	sub	sub	NN
cord-304876-txaoz7oh	506	75	-	-	JJ
cord-304876-txaoz7oh	506	76	group	group	NN
cord-304876-txaoz7oh	506	77	that	that	WDT
cord-304876-txaoz7oh	506	78	contains	contain	VBZ
cord-304876-txaoz7oh	506	79	types	type	NNS
cord-304876-txaoz7oh	506	80	CVA-21	CVA-21	NNP
cord-304876-txaoz7oh	506	81	Rhinoviruses	Rhinoviruses	NNP
cord-304876-txaoz7oh	506	82	and	and	CC
cord-304876-txaoz7oh	506	83	respiratory	respiratory	JJ
cord-304876-txaoz7oh	506	84	enteroviruses	enterovirus	NNS
cord-304876-txaoz7oh	506	85	:	:	:
cord-304876-txaoz7oh	507	1	Not	not	RB
cord-304876-txaoz7oh	507	2	as	as	RB
cord-304876-txaoz7oh	507	3	simple	simple	JJ
cord-304876-txaoz7oh	507	4	as	as	IN
cord-304876-txaoz7oh	507	5	ABC	ABC	NNP
cord-304876-txaoz7oh	507	6	Enterovirus	Enterovirus	NNP
cord-304876-txaoz7oh	507	7	71	71	CD
cord-304876-txaoz7oh	507	8	infection	infection	NN
cord-304876-txaoz7oh	507	9	and	and	CC
cord-304876-txaoz7oh	507	10	vaccines	vaccine	NNS
cord-304876-txaoz7oh	507	11	Enterovirus	Enterovirus	NNP
cord-304876-txaoz7oh	507	12	71	71	CD
cord-304876-txaoz7oh	507	13	infection	infection	NN
cord-304876-txaoz7oh	507	14	and	and	CC
cord-304876-txaoz7oh	507	15	neurological	neurological	JJ
cord-304876-txaoz7oh	507	16	complications	complication	NNS
cord-304876-txaoz7oh	507	17	Human	human	JJ
cord-304876-txaoz7oh	507	18	coronaviruses	coronaviruse	NNS
cord-304876-txaoz7oh	507	19	:	:	:
cord-304876-txaoz7oh	507	20	A	a	DT
cord-304876-txaoz7oh	507	21	review	review	NN
cord-304876-txaoz7oh	507	22	of	of	IN
cord-304876-txaoz7oh	507	23	virus	virus	NN
cord-304876-txaoz7oh	507	24	-	-	HYPH
cord-304876-txaoz7oh	507	25	host	host	NN
cord-304876-txaoz7oh	507	26	interactions	interaction	NNS
cord-304876-txaoz7oh	507	27	Coronavirus	Coronavirus	NNP
cord-304876-txaoz7oh	507	28	229E	229e	CD
cord-304876-txaoz7oh	507	29	-	-	HYPH
cord-304876-txaoz7oh	507	30	related	relate	VBN
cord-304876-txaoz7oh	507	31	pneumonia	pneumonia	NN
cord-304876-txaoz7oh	507	32	in	in	IN
cord-304876-txaoz7oh	507	33	immunocompromised	immunocompromised	JJ
cord-304876-txaoz7oh	507	34	patients	patient	NNS
cord-304876-txaoz7oh	507	35	Understanding	understand	VBG
cord-304876-txaoz7oh	507	36	human	human	JJ
cord-304876-txaoz7oh	507	37	coronavirus	coronavirus	NN
cord-304876-txaoz7oh	507	38	HCoV	HCoV	NNP
cord-304876-txaoz7oh	507	39	-	-	:
cord-304876-txaoz7oh	507	40	NL63	NL63	NNP
cord-304876-txaoz7oh	507	41	Coronavirus	Coronavirus	NNP
cord-304876-txaoz7oh	507	42	HKU1	HKU1	NNP
cord-304876-txaoz7oh	507	43	Infection	Infection	NNP
cord-304876-txaoz7oh	507	44	in	in	IN
cord-304876-txaoz7oh	507	45	the	the	DT
cord-304876-txaoz7oh	507	46	United	United	NNP
cord-304876-txaoz7oh	507	47	States	States	NNP
cord-304876-txaoz7oh	507	48	Description	Description	NNP
cord-304876-txaoz7oh	507	49	and	and	CC
cord-304876-txaoz7oh	507	50	clinical	clinical	JJ
cord-304876-txaoz7oh	507	51	treatment	treatment	NN
cord-304876-txaoz7oh	507	52	of	of	IN
cord-304876-txaoz7oh	507	53	an	an	DT
cord-304876-txaoz7oh	507	54	early	early	JJ
cord-304876-txaoz7oh	507	55	outbreak	outbreak	NN
cord-304876-txaoz7oh	507	56	of	of	IN
cord-304876-txaoz7oh	507	57	severe	severe	JJ
cord-304876-txaoz7oh	507	58	acute	acute	JJ
cord-304876-txaoz7oh	507	59	respiratory	respiratory	JJ
cord-304876-txaoz7oh	507	60	syndrome	syndrome	NN
cord-304876-txaoz7oh	507	61	(	(	-LRB-
cord-304876-txaoz7oh	507	62	SARS	SARS	NNP
cord-304876-txaoz7oh	507	63	)	)	-RRB-
cord-304876-txaoz7oh	507	64	in	in	IN
cord-304876-txaoz7oh	507	65	Guangzhou	Guangzhou	NNP
cord-304876-txaoz7oh	507	66	,	,	,
cord-304876-txaoz7oh	507	67	PR	PR	NNP
cord-304876-txaoz7oh	507	68	China	China	NNP
cord-304876-txaoz7oh	507	69	Severe	severe	JJ
cord-304876-txaoz7oh	507	70	acute	acute	JJ
cord-304876-txaoz7oh	507	71	respiratory	respiratory	JJ
cord-304876-txaoz7oh	507	72	syndrome	syndrome	NN
cord-304876-txaoz7oh	507	73	coronavirus	coronavirus	NN
cord-304876-txaoz7oh	507	74	as	as	IN
cord-304876-txaoz7oh	507	75	an	an	DT
cord-304876-txaoz7oh	507	76	agent	agent	NN
cord-304876-txaoz7oh	507	77	of	of	IN
cord-304876-txaoz7oh	507	78	emerging	emerge	VBG
cord-304876-txaoz7oh	507	79	and	and	CC
cord-304876-txaoz7oh	507	80	reemerging	reemerge	VBG
cord-304876-txaoz7oh	507	81	infection	infection	NN
cord-304876-txaoz7oh	507	82	epidemiological	epidemiological	JJ
cord-304876-txaoz7oh	507	83	findings	finding	NNS
cord-304876-txaoz7oh	507	84	from	from	IN
cord-304876-txaoz7oh	507	85	a	a	DT
cord-304876-txaoz7oh	507	86	retrospective	retrospective	JJ
cord-304876-txaoz7oh	507	87	investigation	investigation	NN
cord-304876-txaoz7oh	507	88	Middle	Middle	NNP
cord-304876-txaoz7oh	507	89	east	east	NNP
cord-304876-txaoz7oh	507	90	respiratory	respiratory	JJ
cord-304876-txaoz7oh	507	91	syndrome	syndrome	NN
cord-304876-txaoz7oh	507	92	Coronavirusesdrug	Coronavirusesdrug	NNP
cord-304876-txaoz7oh	507	93	discovery	discovery	NN
cord-304876-txaoz7oh	507	94	and	and	CC
cord-304876-txaoz7oh	507	95	therapeutic	therapeutic	JJ
cord-304876-txaoz7oh	507	96	options	option	NNS
cord-304876-txaoz7oh	507	97	Infection	infection	NN
cord-304876-txaoz7oh	507	98	with	with	IN
cord-304876-txaoz7oh	507	99	Middle	Middle	NNP
cord-304876-txaoz7oh	507	100	East	East	NNP
cord-304876-txaoz7oh	507	101	respiratory	respiratory	JJ
cord-304876-txaoz7oh	507	102	syndrome	syndrome	NN
cord-304876-txaoz7oh	507	103	coronavirus	coronavirus	NN
cord-304876-txaoz7oh	507	104	Antimicrobial	Antimicrobial	NNP
cord-304876-txaoz7oh	507	105	strategies	strategy	NNS
cord-304876-txaoz7oh	507	106	:	:	:
cord-304876-txaoz7oh	507	107	inhibition	inhibition	NN
cord-304876-txaoz7oh	507	108	of	of	IN
cord-304876-txaoz7oh	507	109	viral	viral	JJ
cord-304876-txaoz7oh	507	110	polymerases	polymerase	NNS
cord-304876-txaoz7oh	507	111	by	by	IN
cord-304876-txaoz7oh	507	112	3'-hydroxyl	3'-hydroxyl	CD
cord-304876-txaoz7oh	507	113	nucleosides	nucleoside	NNS
cord-304876-txaoz7oh	508	1	Influenza	Influenza	NNP
cord-304876-txaoz7oh	508	2	A	a	DT
cord-304876-txaoz7oh	508	3	viruses	virus	NNS
cord-304876-txaoz7oh	508	4	:	:	:
cord-304876-txaoz7oh	508	5	new	new	JJ
cord-304876-txaoz7oh	508	6	research	research	NN
cord-304876-txaoz7oh	508	7	developments	development	NNS
cord-304876-txaoz7oh	509	1	The	the	DT
cord-304876-txaoz7oh	509	2	RNA	RNA	NNP
cord-304876-txaoz7oh	509	3	polymerase	polymerase	NN
cord-304876-txaoz7oh	509	4	of	of	IN
cord-304876-txaoz7oh	509	5	influenza	influenza	NN
cord-304876-txaoz7oh	509	6	a	a	DT
cord-304876-txaoz7oh	509	7	virus	virus	NN
cord-304876-txaoz7oh	509	8	:	:	:
cord-304876-txaoz7oh	509	9	mechanisms	mechanism	NNS
cord-304876-txaoz7oh	509	10	of	of	IN
cord-304876-txaoz7oh	509	11	viral	viral	JJ
cord-304876-txaoz7oh	509	12	transcription	transcription	NN
cord-304876-txaoz7oh	509	13	and	and	CC
cord-304876-txaoz7oh	509	14	replication	replication	NN
cord-304876-txaoz7oh	510	1	Structural	structural	JJ
cord-304876-txaoz7oh	510	2	insight	insight	NN
cord-304876-txaoz7oh	510	3	into	into	IN
cord-304876-txaoz7oh	510	4	cap	cap	NN
cord-304876-txaoz7oh	510	5	-	-	HYPH
cord-304876-txaoz7oh	510	6	snatching	snatching	NN
cord-304876-txaoz7oh	510	7	and	and	CC
cord-304876-txaoz7oh	510	8	RNA	RNA	NNP
cord-304876-txaoz7oh	510	9	synthesis	synthesis	NN
cord-304876-txaoz7oh	510	10	by	by	IN
cord-304876-txaoz7oh	510	11	influenza	influenza	NN
cord-304876-txaoz7oh	510	12	polymerase	polymerase	NN
cord-304876-txaoz7oh	510	13	Role	role	NN
cord-304876-txaoz7oh	510	14	of	of	IN
cord-304876-txaoz7oh	510	15	two	two	CD
cord-304876-txaoz7oh	510	16	of	of	IN
cord-304876-txaoz7oh	510	17	the	the	DT
cord-304876-txaoz7oh	510	18	influenza	influenza	NN
cord-304876-txaoz7oh	510	19	virus	virus	NN
cord-304876-txaoz7oh	510	20	core	core	NN
cord-304876-txaoz7oh	510	21	P	p	NN
cord-304876-txaoz7oh	510	22	proteins	protein	NNS
cord-304876-txaoz7oh	510	23	in	in	IN
cord-304876-txaoz7oh	510	24	recognizing	recognize	VBG
cord-304876-txaoz7oh	510	25	cap	cap	NN
cord-304876-txaoz7oh	510	26	1	1	CD
cord-304876-txaoz7oh	510	27	structures	structure	NNS
cord-304876-txaoz7oh	510	28	(	(	-LRB-
cord-304876-txaoz7oh	510	29	m7GpppNm	m7GpppNm	NNP
cord-304876-txaoz7oh	510	30	)	)	-RRB-
cord-304876-txaoz7oh	510	31	on	on	IN
cord-304876-txaoz7oh	510	32	RNAs	rna	NNS
cord-304876-txaoz7oh	510	33	and	and	CC
cord-304876-txaoz7oh	510	34	in	in	IN
cord-304876-txaoz7oh	510	35	initiating	initiate	VBG
cord-304876-txaoz7oh	510	36	viral	viral	JJ
cord-304876-txaoz7oh	510	37	RNA	RNA	NNP
cord-304876-txaoz7oh	510	38	transcription	transcription	NN
cord-304876-txaoz7oh	510	39	Identification	identification	NN
cord-304876-txaoz7oh	510	40	of	of	IN
cord-304876-txaoz7oh	510	41	the	the	DT
cord-304876-txaoz7oh	510	42	cap	cap	NN
cord-304876-txaoz7oh	510	43	binding	bind	VBG
cord-304876-txaoz7oh	510	44	protein	protein	NN
cord-304876-txaoz7oh	510	45	of	of	IN
cord-304876-txaoz7oh	510	46	influenza	influenza	NN
cord-304876-txaoz7oh	510	47	virus	virus	NN
cord-304876-txaoz7oh	511	1	The	the	DT
cord-304876-txaoz7oh	511	2	structural	structural	JJ
cord-304876-txaoz7oh	511	3	basis	basis	NN
cord-304876-txaoz7oh	511	4	for	for	IN
cord-304876-txaoz7oh	511	5	cap	cap	NN
cord-304876-txaoz7oh	511	6	binding	binding	NN
cord-304876-txaoz7oh	511	7	by	by	IN
cord-304876-txaoz7oh	511	8	influenza	influenza	NN
cord-304876-txaoz7oh	511	9	virus	virus	NN
cord-304876-txaoz7oh	511	10	polymerase	polymerase	NN
cord-304876-txaoz7oh	511	11	subunit	subunit	NN
cord-304876-txaoz7oh	511	12	PB2	PB2	NNP
cord-304876-txaoz7oh	512	1	The	the	DT
cord-304876-txaoz7oh	512	2	cap	cap	NN
cord-304876-txaoz7oh	512	3	-	-	HYPH
cord-304876-txaoz7oh	512	4	snatching	snatch	VBG
cord-304876-txaoz7oh	512	5	endonuclease	endonuclease	NN
cord-304876-txaoz7oh	512	6	of	of	IN
cord-304876-txaoz7oh	512	7	influenza	influenza	NN
cord-304876-txaoz7oh	512	8	virus	virus	NN
cord-304876-txaoz7oh	512	9	polymerase	polymerase	NN
cord-304876-txaoz7oh	512	10	resides	reside	VBZ
cord-304876-txaoz7oh	512	11	in	in	IN
cord-304876-txaoz7oh	512	12	the	the	DT
cord-304876-txaoz7oh	512	13	PA	PA	NNP
cord-304876-txaoz7oh	512	14	subunit	subunit	NN
cord-304876-txaoz7oh	512	15	Crystal	Crystal	NNP
cord-304876-txaoz7oh	512	16	structure	structure	NN
cord-304876-txaoz7oh	512	17	of	of	IN
cord-304876-txaoz7oh	512	18	an	an	DT
cord-304876-txaoz7oh	512	19	avian	avian	JJ
cord-304876-txaoz7oh	512	20	influenza	influenza	NN
cord-304876-txaoz7oh	512	21	polymerase	polymerase	NN
cord-304876-txaoz7oh	513	1	PA	PA	NNP
cord-304876-txaoz7oh	513	2	N	N	NNP
cord-304876-txaoz7oh	513	3	reveals	reveal	VBZ
cord-304876-txaoz7oh	513	4	an	an	DT
cord-304876-txaoz7oh	513	5	endonuclease	endonuclease	NN
cord-304876-txaoz7oh	513	6	active	active	JJ
cord-304876-txaoz7oh	513	7	site	site	NN
cord-304876-txaoz7oh	513	8	Structure	structure	NN
cord-304876-txaoz7oh	513	9	of	of	IN
cord-304876-txaoz7oh	513	10	influenza	influenza	NN
cord-304876-txaoz7oh	513	11	A	a	DT
cord-304876-txaoz7oh	513	12	polymerase	polymerase	NN
cord-304876-txaoz7oh	513	13	bound	bind	VBN
cord-304876-txaoz7oh	513	14	to	to	IN
cord-304876-txaoz7oh	513	15	the	the	DT
cord-304876-txaoz7oh	513	16	viral	viral	JJ
cord-304876-txaoz7oh	513	17	RNA	RNA	NNP
cord-304876-txaoz7oh	513	18	promoter	promoter	NN
cord-304876-txaoz7oh	513	19	Conserved	conserved	JJ
cord-304876-txaoz7oh	513	20	features	feature	NNS
cord-304876-txaoz7oh	513	21	of	of	IN
cord-304876-txaoz7oh	513	22	the	the	DT
cord-304876-txaoz7oh	513	23	PB2	PB2	NNP
cord-304876-txaoz7oh	513	24	627	627	CD
cord-304876-txaoz7oh	513	25	domain	domain	NN
cord-304876-txaoz7oh	513	26	impact	impact	NN
cord-304876-txaoz7oh	513	27	influenza	influenza	NN
cord-304876-txaoz7oh	513	28	virus	virus	NN
cord-304876-txaoz7oh	513	29	polymerase	polymerase	NN
cord-304876-txaoz7oh	513	30	function	function	NN
cord-304876-txaoz7oh	513	31	and	and	CC
cord-304876-txaoz7oh	513	32	replication	replication	NN
cord-304876-txaoz7oh	513	33	Role	role	NN
cord-304876-txaoz7oh	513	34	of	of	IN
cord-304876-txaoz7oh	513	35	the	the	DT
cord-304876-txaoz7oh	513	36	PB2	PB2	NNP
cord-304876-txaoz7oh	513	37	627	627	CD
cord-304876-txaoz7oh	513	38	domain	domain	NN
cord-304876-txaoz7oh	513	39	in	in	IN
cord-304876-txaoz7oh	513	40	influenza	influenza	NN
cord-304876-txaoz7oh	513	41	A	a	DT
cord-304876-txaoz7oh	513	42	virus	virus	NN
cord-304876-txaoz7oh	513	43	polymerase	polymerase	NN
cord-304876-txaoz7oh	513	44	function	function	NN
cord-304876-txaoz7oh	513	45	The	the	DT
cord-304876-txaoz7oh	513	46	role	role	NN
cord-304876-txaoz7oh	513	47	of	of	IN
cord-304876-txaoz7oh	513	48	the	the	DT
cord-304876-txaoz7oh	513	49	priming	priming	NN
cord-304876-txaoz7oh	513	50	loop	loop	NN
cord-304876-txaoz7oh	513	51	in	in	IN
cord-304876-txaoz7oh	513	52	influenza	influenza	NN
cord-304876-txaoz7oh	513	53	A	a	DT
cord-304876-txaoz7oh	513	54	virus	virus	NN
cord-304876-txaoz7oh	514	1	RNA	RNA	NNP
cord-304876-txaoz7oh	514	2	synthesis	synthesis	NN
cord-304876-txaoz7oh	515	1	The	the	DT
cord-304876-txaoz7oh	515	2	influenza	influenza	NN
cord-304876-txaoz7oh	515	3	virus	virus	NN
cord-304876-txaoz7oh	515	4	polymerase	polymerase	NN
cord-304876-txaoz7oh	515	5	complex	complex	NN
cord-304876-txaoz7oh	515	6	:	:	:
cord-304876-txaoz7oh	516	1	An	an	DT
cord-304876-txaoz7oh	516	2	update	update	NN
cord-304876-txaoz7oh	516	3	on	on	IN
cord-304876-txaoz7oh	516	4	its	-PRON-	PRP$
cord-304876-txaoz7oh	516	5	structure	structure	NN
cord-304876-txaoz7oh	516	6	,	,	,
cord-304876-txaoz7oh	516	7	functions	function	NNS
cord-304876-txaoz7oh	516	8	,	,	,
cord-304876-txaoz7oh	516	9	and	and	CC
cord-304876-txaoz7oh	516	10	significance	significance	NN
cord-304876-txaoz7oh	516	11	for	for	IN
cord-304876-txaoz7oh	516	12	antiviral	antiviral	JJ
cord-304876-txaoz7oh	516	13	drug	drug	NN
cord-304876-txaoz7oh	516	14	design	design	NN
cord-304876-txaoz7oh	516	15	Initiation	initiation	NN
cord-304876-txaoz7oh	516	16	and	and	CC
cord-304876-txaoz7oh	516	17	regulation	regulation	NN
cord-304876-txaoz7oh	516	18	of	of	IN
cord-304876-txaoz7oh	516	19	paramyxovirus	paramyxovirus	JJ
cord-304876-txaoz7oh	516	20	transcription	transcription	NN
cord-304876-txaoz7oh	516	21	and	and	CC
cord-304876-txaoz7oh	516	22	replication	replication	NN
cord-304876-txaoz7oh	516	23	Polymerases	Polymerases	NNPS
cord-304876-txaoz7oh	516	24	of	of	IN
cord-304876-txaoz7oh	516	25	paramyxoviruses	paramyxovirus	NNS
cord-304876-txaoz7oh	516	26	and	and	CC
cord-304876-txaoz7oh	516	27	pneumoviruses	pneumoviruses	NNP
cord-304876-txaoz7oh	516	28	New	new	JJ
cord-304876-txaoz7oh	516	29	antiviral	antiviral	JJ
cord-304876-txaoz7oh	516	30	approaches	approach	NNS
cord-304876-txaoz7oh	516	31	for	for	IN
cord-304876-txaoz7oh	516	32	respiratory	respiratory	JJ
cord-304876-txaoz7oh	516	33	syncytial	syncytial	JJ
cord-304876-txaoz7oh	516	34	virus	virus	NN
cord-304876-txaoz7oh	516	35	and	and	CC
cord-304876-txaoz7oh	516	36	other	other	JJ
cord-304876-txaoz7oh	516	37	mononegaviruses	mononegaviruse	NNS
cord-304876-txaoz7oh	516	38	:	:	:
cord-304876-txaoz7oh	516	39	Inhibiting	inhibit	VBG
cord-304876-txaoz7oh	516	40	the	the	DT
cord-304876-txaoz7oh	516	41	RNA	RNA	NNP
cord-304876-txaoz7oh	516	42	polymerase	polymerase	NN
cord-304876-txaoz7oh	516	43	Transcription	transcription	NN
cord-304876-txaoz7oh	516	44	elongation	elongation	NN
cord-304876-txaoz7oh	516	45	factor	factor	NN
cord-304876-txaoz7oh	516	46	of	of	IN
cord-304876-txaoz7oh	516	47	respiratory	respiratory	JJ
cord-304876-txaoz7oh	516	48	syncytial	syncytial	JJ
cord-304876-txaoz7oh	516	49	virus	virus	NN
cord-304876-txaoz7oh	516	50	,	,	,
cord-304876-txaoz7oh	516	51	a	a	DT
cord-304876-txaoz7oh	516	52	nonsegmented	nonsegmente	VBN
cord-304876-txaoz7oh	516	53	negative	negative	JJ
cord-304876-txaoz7oh	516	54	-	-	HYPH
cord-304876-txaoz7oh	516	55	strand	strand	NN
cord-304876-txaoz7oh	516	56	RNA	RNA	NNP
cord-304876-txaoz7oh	516	57	virus	virus	NN
cord-304876-txaoz7oh	516	58	Production	production	NN
cord-304876-txaoz7oh	516	59	of	of	IN
cord-304876-txaoz7oh	516	60	infectious	infectious	JJ
cord-304876-txaoz7oh	516	61	human	human	JJ
cord-304876-txaoz7oh	516	62	respiratory	respiratory	JJ
cord-304876-txaoz7oh	516	63	syncytial	syncytial	JJ
cord-304876-txaoz7oh	516	64	virus	virus	NN
cord-304876-txaoz7oh	516	65	from	from	IN
cord-304876-txaoz7oh	516	66	cloned	clone	VBN
cord-304876-txaoz7oh	516	67	cDNA	cdna	NN
cord-304876-txaoz7oh	516	68	confirms	confirm	VBZ
cord-304876-txaoz7oh	516	69	an	an	DT
cord-304876-txaoz7oh	516	70	essential	essential	JJ
cord-304876-txaoz7oh	516	71	role	role	NN
cord-304876-txaoz7oh	516	72	for	for	IN
cord-304876-txaoz7oh	516	73	the	the	DT
cord-304876-txaoz7oh	516	74	transcription	transcription	NN
cord-304876-txaoz7oh	516	75	elongation	elongation	NN
cord-304876-txaoz7oh	516	76	factor	factor	NN
cord-304876-txaoz7oh	516	77	from	from	IN
cord-304876-txaoz7oh	516	78	the	the	DT
cord-304876-txaoz7oh	516	79	5	5	CD
cord-304876-txaoz7oh	516	80	'	'	``
cord-304876-txaoz7oh	516	81	proximal	proximal	JJ
cord-304876-txaoz7oh	516	82	open	open	JJ
cord-304876-txaoz7oh	516	83	reading	reading	NN
cord-304876-txaoz7oh	516	84	frame	frame	NN
cord-304876-txaoz7oh	516	85	of	of	IN
cord-304876-txaoz7oh	516	86	the	the	DT
cord-304876-txaoz7oh	516	87	M2	M2	NNP
cord-304876-txaoz7oh	516	88	mRNA	mrna	NN
cord-304876-txaoz7oh	516	89	in	in	IN
cord-304876-txaoz7oh	516	90	gene	gene	NN
cord-304876-txaoz7oh	516	91	expression	expression	NN
cord-304876-txaoz7oh	516	92	and	and	CC
cord-304876-txaoz7oh	516	93	provides	provide	VBZ
cord-304876-txaoz7oh	516	94	a	a	DT
cord-304876-txaoz7oh	516	95	capability	capability	NN
cord-304876-txaoz7oh	516	96	for	for	IN
cord-304876-txaoz7oh	516	97	vaccine	vaccine	NN
cord-304876-txaoz7oh	516	98	development	development	NN
cord-304876-txaoz7oh	516	99	Bacterial	bacterial	JJ
cord-304876-txaoz7oh	516	100	expression	expression	NN
cord-304876-txaoz7oh	516	101	of	of	IN
cord-304876-txaoz7oh	516	102	human	human	JJ
cord-304876-txaoz7oh	516	103	respiratory	respiratory	JJ
cord-304876-txaoz7oh	516	104	syncytial	syncytial	JJ
cord-304876-txaoz7oh	516	105	viral	viral	JJ
cord-304876-txaoz7oh	516	106	phosphoprotein	phosphoprotein	NN
cord-304876-txaoz7oh	516	107	P	p	NN
cord-304876-txaoz7oh	516	108	and	and	CC
cord-304876-txaoz7oh	516	109	identification	identification	NN
cord-304876-txaoz7oh	516	110	of	of	IN
cord-304876-txaoz7oh	516	111	Ser237	ser237	CD
cord-304876-txaoz7oh	516	112	as	as	IN
cord-304876-txaoz7oh	516	113	the	the	DT
cord-304876-txaoz7oh	516	114	site	site	NN
cord-304876-txaoz7oh	516	115	of	of	IN
cord-304876-txaoz7oh	516	116	phosphorylation	phosphorylation	NN
cord-304876-txaoz7oh	516	117	by	by	IN
cord-304876-txaoz7oh	516	118	cellular	cellular	JJ
cord-304876-txaoz7oh	516	119	casein	casein	NN
cord-304876-txaoz7oh	516	120	kinase	kinase	NN
cord-304876-txaoz7oh	516	121	II	II	NNP
cord-304876-txaoz7oh	516	122	New	new	JJ
cord-304876-txaoz7oh	516	123	insights	insight	NNS
cord-304876-txaoz7oh	516	124	into	into	IN
cord-304876-txaoz7oh	516	125	structural	structural	JJ
cord-304876-txaoz7oh	516	126	disorder	disorder	NN
cord-304876-txaoz7oh	516	127	in	in	IN
cord-304876-txaoz7oh	516	128	human	human	JJ
cord-304876-txaoz7oh	516	129	respiratory	respiratory	JJ
cord-304876-txaoz7oh	516	130	syncytial	syncytial	JJ
cord-304876-txaoz7oh	516	131	virus	virus	NN
cord-304876-txaoz7oh	516	132	phosphoprotein	phosphoprotein	NN
cord-304876-txaoz7oh	516	133	and	and	CC
cord-304876-txaoz7oh	516	134	implications	implication	NNS
cord-304876-txaoz7oh	516	135	for	for	IN
cord-304876-txaoz7oh	516	136	binding	bind	VBG
cord-304876-txaoz7oh	516	137	of	of	IN
cord-304876-txaoz7oh	516	138	protein	protein	NN
cord-304876-txaoz7oh	516	139	partners	partner	NNS
cord-304876-txaoz7oh	516	140	Interaction	Interaction	NNP
cord-304876-txaoz7oh	516	141	between	between	IN
cord-304876-txaoz7oh	516	142	human	human	JJ
cord-304876-txaoz7oh	516	143	respiratory	respiratory	JJ
cord-304876-txaoz7oh	516	144	syncytial	syncytial	JJ
cord-304876-txaoz7oh	516	145	virus	virus	NN
cord-304876-txaoz7oh	516	146	(	(	-LRB-
cord-304876-txaoz7oh	516	147	RSV	RSV	NNP
cord-304876-txaoz7oh	516	148	)	)	-RRB-
cord-304876-txaoz7oh	516	149	M2	M2	NNP
cord-304876-txaoz7oh	516	150	-	-	SYM
cord-304876-txaoz7oh	516	151	1	1	CD
cord-304876-txaoz7oh	516	152	and	and	CC
cord-304876-txaoz7oh	516	153	P	p	NN
cord-304876-txaoz7oh	516	154	proteins	protein	NNS
cord-304876-txaoz7oh	516	155	is	be	VBZ
cord-304876-txaoz7oh	516	156	required	require	VBN
cord-304876-txaoz7oh	516	157	for	for	IN
cord-304876-txaoz7oh	516	158	reconstitution	reconstitution	NN
cord-304876-txaoz7oh	516	159	of	of	IN
cord-304876-txaoz7oh	516	160	M2	M2	NNP
cord-304876-txaoz7oh	516	161	-	-	HYPH
cord-304876-txaoz7oh	516	162	1-dependent	1-dependent	CD
cord-304876-txaoz7oh	516	163	RSV	RSV	NNP
cord-304876-txaoz7oh	516	164	minigenome	minigenome	NNP
cord-304876-txaoz7oh	516	165	activity	activity	NN
cord-304876-txaoz7oh	516	166	Structure	Structure	NNP
cord-304876-txaoz7oh	516	167	and	and	CC
cord-304876-txaoz7oh	516	168	functional	functional	JJ
cord-304876-txaoz7oh	516	169	analysis	analysis	NN
cord-304876-txaoz7oh	516	170	of	of	IN
cord-304876-txaoz7oh	516	171	the	the	DT
cord-304876-txaoz7oh	516	172	RNA	RNA	NNP
cord-304876-txaoz7oh	516	173	-	-	,
cord-304876-txaoz7oh	516	174	and	and	CC
cord-304876-txaoz7oh	516	175	viral	viral	JJ
cord-304876-txaoz7oh	516	176	phosphoprotein	phosphoprotein	NN
cord-304876-txaoz7oh	516	177	-	-	HYPH
cord-304876-txaoz7oh	516	178	binding	bind	VBG
cord-304876-txaoz7oh	516	179	domain	domain	NN
cord-304876-txaoz7oh	516	180	of	of	IN
cord-304876-txaoz7oh	516	181	respiratory	respiratory	JJ
cord-304876-txaoz7oh	516	182	syncytial	syncytial	JJ
cord-304876-txaoz7oh	516	183	virus	virus	NN
cord-304876-txaoz7oh	516	184	M2	M2	NNP
cord-304876-txaoz7oh	516	185	-	-	SYM
cord-304876-txaoz7oh	516	186	1	1	CD
cord-304876-txaoz7oh	516	187	protein	protein	NN
cord-304876-txaoz7oh	516	188	Characterization	characterization	NN
cord-304876-txaoz7oh	516	189	of	of	IN
cord-304876-txaoz7oh	516	190	a	a	DT
cord-304876-txaoz7oh	516	191	viral	viral	JJ
cord-304876-txaoz7oh	516	192	phosphoprotein	phosphoprotein	NN
cord-304876-txaoz7oh	516	193	binding	bind	VBG
cord-304876-txaoz7oh	516	194	site	site	NN
cord-304876-txaoz7oh	516	195	on	on	IN
cord-304876-txaoz7oh	516	196	the	the	DT
cord-304876-txaoz7oh	516	197	surface	surface	NN
cord-304876-txaoz7oh	516	198	of	of	IN
cord-304876-txaoz7oh	516	199	the	the	DT
cord-304876-txaoz7oh	516	200	respiratory	respiratory	JJ
cord-304876-txaoz7oh	516	201	syncytial	syncytial	JJ
cord-304876-txaoz7oh	516	202	nucleoprotein	nucleoprotein	JJ
cord-304876-txaoz7oh	516	203	Central	central	JJ
cord-304876-txaoz7oh	516	204	role	role	NN
cord-304876-txaoz7oh	516	205	of	of	IN
cord-304876-txaoz7oh	516	206	the	the	DT
cord-304876-txaoz7oh	516	207	respiratory	respiratory	JJ
cord-304876-txaoz7oh	516	208	syncytial	syncytial	JJ
cord-304876-txaoz7oh	516	209	virus	virus	NN
cord-304876-txaoz7oh	516	210	matrix	matrix	NN
cord-304876-txaoz7oh	516	211	protein	protein	NN
cord-304876-txaoz7oh	516	212	in	in	IN
cord-304876-txaoz7oh	516	213	infection	infection	NN
cord-304876-txaoz7oh	516	214	Structure	Structure	NNP
cord-304876-txaoz7oh	516	215	of	of	IN
cord-304876-txaoz7oh	516	216	the	the	DT
cord-304876-txaoz7oh	516	217	L	L	NNP
cord-304876-txaoz7oh	516	218	protein	protein	NN
cord-304876-txaoz7oh	516	219	of	of	IN
cord-304876-txaoz7oh	516	220	vesicular	vesicular	JJ
cord-304876-txaoz7oh	516	221	stomatitis	stomatitis	NN
cord-304876-txaoz7oh	516	222	virus	virus	NN
cord-304876-txaoz7oh	516	223	from	from	IN
cord-304876-txaoz7oh	516	224	electron	electron	NN
cord-304876-txaoz7oh	516	225	cryomicroscopy	cryomicroscopy	NNP
cord-304876-txaoz7oh	516	226	Sequence	sequence	NN
cord-304876-txaoz7oh	516	227	comparison	comparison	NN
cord-304876-txaoz7oh	516	228	of	of	IN
cord-304876-txaoz7oh	516	229	five	five	CD
cord-304876-txaoz7oh	516	230	polymerases	polymerase	NNS
cord-304876-txaoz7oh	516	231	(	(	-LRB-
cord-304876-txaoz7oh	516	232	L	l	NN
cord-304876-txaoz7oh	516	233	proteins	protein	NNS
cord-304876-txaoz7oh	516	234	)	)	-RRB-
cord-304876-txaoz7oh	516	235	of	of	IN
cord-304876-txaoz7oh	516	236	unsegmented	unsegmented	JJ
cord-304876-txaoz7oh	516	237	negative	negative	JJ
cord-304876-txaoz7oh	516	238	-	-	HYPH
cord-304876-txaoz7oh	516	239	strand	strand	NN
cord-304876-txaoz7oh	516	240	RNA	RNA	NNP
cord-304876-txaoz7oh	516	241	viruses	virus	NNS
cord-304876-txaoz7oh	516	242	:	:	:
cord-304876-txaoz7oh	516	243	theoretical	theoretical	JJ
cord-304876-txaoz7oh	516	244	assignment	assignment	NN
cord-304876-txaoz7oh	516	245	of	of	IN
cord-304876-txaoz7oh	516	246	functional	functional	JJ
cord-304876-txaoz7oh	516	247	domains	domain	NNS
cord-304876-txaoz7oh	516	248	Molecular	molecular	JJ
cord-304876-txaoz7oh	516	249	architecture	architecture	NN
cord-304876-txaoz7oh	516	250	of	of	IN
cord-304876-txaoz7oh	516	251	the	the	DT
cord-304876-txaoz7oh	516	252	vesicular	vesicular	JJ
cord-304876-txaoz7oh	516	253	stomatitis	stomatitis	NN
cord-304876-txaoz7oh	516	254	virus	virus	NN
cord-304876-txaoz7oh	516	255	RNA	rna	NN
cord-304876-txaoz7oh	516	256	polymerase	polymerase	NN
cord-304876-txaoz7oh	516	257	Template	template	NN
cord-304876-txaoz7oh	516	258	-	-	HYPH
cord-304876-txaoz7oh	516	259	based	base	VBN
cord-304876-txaoz7oh	516	260	protein	protein	NN
cord-304876-txaoz7oh	516	261	structure	structure	NN
cord-304876-txaoz7oh	516	262	modeling	modeling	NN
cord-304876-txaoz7oh	516	263	using	use	VBG
cord-304876-txaoz7oh	516	264	the	the	DT
cord-304876-txaoz7oh	516	265	RaptorX	raptorx	NN
cord-304876-txaoz7oh	516	266	web	web	NN
cord-304876-txaoz7oh	516	267	server	server	NN
cord-304876-txaoz7oh	516	268	X	x	NN
cord-304876-txaoz7oh	516	269	-	-	NN
cord-304876-txaoz7oh	516	270	ray	ray	JJ
cord-304876-txaoz7oh	516	271	structure	structure	NN
cord-304876-txaoz7oh	516	272	and	and	CC
cord-304876-txaoz7oh	516	273	activities	activity	NNS
cord-304876-txaoz7oh	516	274	of	of	IN
cord-304876-txaoz7oh	516	275	an	an	DT
cord-304876-txaoz7oh	516	276	essential	essential	JJ
cord-304876-txaoz7oh	516	277	mononegavirales	mononegavirale	NNS
cord-304876-txaoz7oh	516	278	L	l	NN
cord-304876-txaoz7oh	516	279	-	-	HYPH
cord-304876-txaoz7oh	516	280	protein	protein	NN
cord-304876-txaoz7oh	516	281	domain	domain	NN
cord-304876-txaoz7oh	516	282	A	a	DT
cord-304876-txaoz7oh	516	283	conserved	conserved	JJ
cord-304876-txaoz7oh	516	284	motif	motif	NN
cord-304876-txaoz7oh	516	285	in	in	IN
cord-304876-txaoz7oh	516	286	region	region	NN
cord-304876-txaoz7oh	516	287	v	v	NN
cord-304876-txaoz7oh	516	288	of	of	IN
cord-304876-txaoz7oh	516	289	the	the	DT
cord-304876-txaoz7oh	516	290	large	large	JJ
cord-304876-txaoz7oh	516	291	polymerase	polymerase	NN
cord-304876-txaoz7oh	516	292	proteins	protein	NNS
cord-304876-txaoz7oh	516	293	of	of	IN
cord-304876-txaoz7oh	516	294	nonsegmented	nonsegmente	VBN
cord-304876-txaoz7oh	516	295	negative	negative	JJ
cord-304876-txaoz7oh	516	296	-	-	HYPH
cord-304876-txaoz7oh	516	297	sense	sense	NN
cord-304876-txaoz7oh	516	298	RNA	RNA	NNP
cord-304876-txaoz7oh	516	299	viruses	virus	NNS
cord-304876-txaoz7oh	516	300	that	that	WDT
cord-304876-txaoz7oh	516	301	is	be	VBZ
cord-304876-txaoz7oh	516	302	essential	essential	JJ
cord-304876-txaoz7oh	516	303	for	for	IN
cord-304876-txaoz7oh	516	304	mRNA	mrna	NN
cord-304876-txaoz7oh	516	305	capping	cap	VBG
cord-304876-txaoz7oh	516	306	In	in	IN
cord-304876-txaoz7oh	516	307	silico	silico	NN
cord-304876-txaoz7oh	516	308	identification	identification	NN
cord-304876-txaoz7oh	516	309	,	,	,
cord-304876-txaoz7oh	516	310	structure	structure	NN
cord-304876-txaoz7oh	516	311	prediction	prediction	NN
cord-304876-txaoz7oh	516	312	and	and	CC
cord-304876-txaoz7oh	516	313	phylogenetic	phylogenetic	JJ
cord-304876-txaoz7oh	516	314	analysis	analysis	NN
cord-304876-txaoz7oh	516	315	of	of	IN
cord-304876-txaoz7oh	516	316	the	the	DT
cord-304876-txaoz7oh	516	317	2	2	CD
cord-304876-txaoz7oh	516	318	0	0	CD
cord-304876-txaoz7oh	516	319	-O	-o	CD
cord-304876-txaoz7oh	516	320	-	-	HYPH
cord-304876-txaoz7oh	516	321	ribose	ribose	NN
cord-304876-txaoz7oh	516	322	(	(	-LRB-
cord-304876-txaoz7oh	516	323	cap	cap	NN
cord-304876-txaoz7oh	516	324	1	1	CD
cord-304876-txaoz7oh	516	325	)	)	-RRB-
cord-304876-txaoz7oh	516	326	methyltransferase	methyltransferase	NN
cord-304876-txaoz7oh	516	327	domain	domain	NN
cord-304876-txaoz7oh	516	328	in	in	IN
cord-304876-txaoz7oh	516	329	the	the	DT
cord-304876-txaoz7oh	516	330	large	large	JJ
cord-304876-txaoz7oh	516	331	structural	structural	JJ
cord-304876-txaoz7oh	516	332	protein	protein	NN
cord-304876-txaoz7oh	516	333	of	of	IN
cord-304876-txaoz7oh	516	334	ssRNA	ssRNA	``
cord-304876-txaoz7oh	516	335	negative	negative	JJ
cord-304876-txaoz7oh	516	336	-	-	HYPH
cord-304876-txaoz7oh	516	337	strand	strand	NN
cord-304876-txaoz7oh	516	338	viruses	virus	NNS
cord-304876-txaoz7oh	516	339	Unconventional	unconventional	JJ
cord-304876-txaoz7oh	516	340	mechanism	mechanism	NN
cord-304876-txaoz7oh	516	341	of	of	IN
cord-304876-txaoz7oh	516	342	mRNA	mrna	NN
cord-304876-txaoz7oh	516	343	capping	cap	VBG
cord-304876-txaoz7oh	516	344	by	by	IN
cord-304876-txaoz7oh	516	345	the	the	DT
cord-304876-txaoz7oh	516	346	RNA	RNA	NNP
cord-304876-txaoz7oh	516	347	-	-	HYPH
cord-304876-txaoz7oh	516	348	dependent	dependent	JJ
cord-304876-txaoz7oh	516	349	RNA	RNA	NNP
cord-304876-txaoz7oh	516	350	polymerase	polymerase	NN
cord-304876-txaoz7oh	516	351	of	of	IN
cord-304876-txaoz7oh	516	352	vesicular	vesicular	JJ
cord-304876-txaoz7oh	516	353	stomatitis	stomatitis	NN
cord-304876-txaoz7oh	516	354	virus	virus	NN
cord-304876-txaoz7oh	517	1	In	in	IN
cord-304876-txaoz7oh	517	2	vitro	vitro	FW
cord-304876-txaoz7oh	517	3	capping	capping	NN
cord-304876-txaoz7oh	517	4	and	and	CC
cord-304876-txaoz7oh	517	5	transcription	transcription	NN
cord-304876-txaoz7oh	517	6	of	of	IN
cord-304876-txaoz7oh	517	7	rhabdoviruses	rhabdovirus	NNS
cord-304876-txaoz7oh	517	8	Conventional	Conventional	NNP
cord-304876-txaoz7oh	517	9	and	and	CC
cord-304876-txaoz7oh	517	10	unconventional	unconventional	JJ
cord-304876-txaoz7oh	517	11	mechanisms	mechanism	NNS
cord-304876-txaoz7oh	517	12	for	for	IN
cord-304876-txaoz7oh	517	13	capping	cap	VBG
cord-304876-txaoz7oh	517	14	viral	viral	JJ
cord-304876-txaoz7oh	517	15	mRNA	mRNA	NNP
cord-304876-txaoz7oh	517	16	RNAdependent	RNAdependent	NNP
cord-304876-txaoz7oh	517	17	RNA	RNA	NNP
cord-304876-txaoz7oh	517	18	polymerases	polymerase	NNS
cord-304876-txaoz7oh	517	19	of	of	IN
cord-304876-txaoz7oh	517	20	picornaviruses	picornavirus	NNS
cord-304876-txaoz7oh	517	21	:	:	:
cord-304876-txaoz7oh	517	22	from	from	IN
cord-304876-txaoz7oh	517	23	the	the	DT
cord-304876-txaoz7oh	517	24	structure	structure	NN
cord-304876-txaoz7oh	517	25	to	to	IN
cord-304876-txaoz7oh	517	26	regulatory	regulatory	JJ
cord-304876-txaoz7oh	517	27	mechanisms	mechanism	NNS
cord-304876-txaoz7oh	517	28	Initiation	Initiation	NNP
cord-304876-txaoz7oh	517	29	of	of	IN
cord-304876-txaoz7oh	517	30	viral	viral	JJ
cord-304876-txaoz7oh	517	31	RNA	RNA	NNP
cord-304876-txaoz7oh	517	32	-	-	HYPH
cord-304876-txaoz7oh	517	33	dependent	dependent	JJ
cord-304876-txaoz7oh	517	34	RNA	RNA	NNP
cord-304876-txaoz7oh	517	35	polymerization	polymerization	NN
cord-304876-txaoz7oh	518	1	A	a	DT
cord-304876-txaoz7oh	518	2	comparison	comparison	NN
cord-304876-txaoz7oh	518	3	of	of	IN
cord-304876-txaoz7oh	518	4	viral	viral	JJ
cord-304876-txaoz7oh	518	5	RNA	RNA	NNP
cord-304876-txaoz7oh	518	6	-	-	HYPH
cord-304876-txaoz7oh	518	7	dependent	dependent	JJ
cord-304876-txaoz7oh	518	8	RNA	RNA	NNP
cord-304876-txaoz7oh	518	9	polymerases	polymerases	VBP
cord-304876-txaoz7oh	518	10	Possible	possible	JJ
cord-304876-txaoz7oh	518	11	unifying	unifying	JJ
cord-304876-txaoz7oh	518	12	mechanism	mechanism	NN
cord-304876-txaoz7oh	518	13	of	of	IN
cord-304876-txaoz7oh	518	14	picornavirus	picornavirus	NNP
cord-304876-txaoz7oh	518	15	genome	genome	NN
cord-304876-txaoz7oh	518	16	replication	replication	NN
cord-304876-txaoz7oh	518	17	Picornaviral	Picornaviral	NNP
cord-304876-txaoz7oh	518	18	polymerase	polymerase	NN
cord-304876-txaoz7oh	518	19	structure	structure	NN
cord-304876-txaoz7oh	518	20	,	,	,
cord-304876-txaoz7oh	518	21	function	function	NN
cord-304876-txaoz7oh	518	22	,	,	,
cord-304876-txaoz7oh	518	23	and	and	CC
cord-304876-txaoz7oh	518	24	fidelity	fidelity	NN
cord-304876-txaoz7oh	518	25	modulation	modulation	NN
cord-304876-txaoz7oh	518	26	Biochemical	biochemical	JJ
cord-304876-txaoz7oh	518	27	and	and	CC
cord-304876-txaoz7oh	518	28	genetic	genetic	JJ
cord-304876-txaoz7oh	518	29	studies	study	NNS
cord-304876-txaoz7oh	518	30	of	of	IN
cord-304876-txaoz7oh	518	31	the	the	DT
cord-304876-txaoz7oh	518	32	VPg	VPg	NNP
cord-304876-txaoz7oh	518	33	uridylylation	uridylylation	NNP
cord-304876-txaoz7oh	518	34	reaction	reaction	NN
cord-304876-txaoz7oh	518	35	catalyzed	catalyze	VBN
cord-304876-txaoz7oh	518	36	by	by	IN
cord-304876-txaoz7oh	518	37	the	the	DT
cord-304876-txaoz7oh	518	38	RNA	RNA	NNP
cord-304876-txaoz7oh	518	39	polymerase	polymerase	NN
cord-304876-txaoz7oh	518	40	of	of	IN
cord-304876-txaoz7oh	518	41	poliovirus	poliovirus	NN
cord-304876-txaoz7oh	518	42	A	a	DT
cord-304876-txaoz7oh	518	43	"	"	``
cord-304876-txaoz7oh	518	44	slide	slide	NN
cord-304876-txaoz7oh	518	45	-	-	HYPH
cord-304876-txaoz7oh	518	46	back	back	NN
cord-304876-txaoz7oh	518	47	"	"	''
cord-304876-txaoz7oh	518	48	mechanism	mechanism	NN
cord-304876-txaoz7oh	518	49	for	for	IN
cord-304876-txaoz7oh	518	50	the	the	DT
cord-304876-txaoz7oh	518	51	initiation	initiation	NN
cord-304876-txaoz7oh	518	52	of	of	IN
cord-304876-txaoz7oh	518	53	protein	protein	NN
cord-304876-txaoz7oh	518	54	-	-	HYPH
cord-304876-txaoz7oh	518	55	primed	prime	VBN
cord-304876-txaoz7oh	518	56	RNA	RNA	NNP
cord-304876-txaoz7oh	518	57	synthesis	synthesis	NN
cord-304876-txaoz7oh	518	58	by	by	IN
cord-304876-txaoz7oh	518	59	the	the	DT
cord-304876-txaoz7oh	518	60	RNA	RNA	NNP
cord-304876-txaoz7oh	518	61	polymerase	polymerase	NN
cord-304876-txaoz7oh	518	62	of	of	IN
cord-304876-txaoz7oh	518	63	poliovirus	poliovirus	NN
cord-304876-txaoz7oh	518	64	Genetic	genetic	JJ
cord-304876-txaoz7oh	518	65	and	and	CC
cord-304876-txaoz7oh	518	66	biochemical	biochemical	JJ
cord-304876-txaoz7oh	518	67	studies	study	NNS
cord-304876-txaoz7oh	518	68	of	of	IN
cord-304876-txaoz7oh	518	69	polioviruscis	polioviruscis	NN
cord-304876-txaoz7oh	518	70	-	-	HYPH
cord-304876-txaoz7oh	518	71	acting	act	VBG
cord-304876-txaoz7oh	518	72	replication	replication	NN
cord-304876-txaoz7oh	518	73	element	element	NN
cord-304876-txaoz7oh	518	74	cre	cre	NN
cord-304876-txaoz7oh	518	75	in	in	IN
cord-304876-txaoz7oh	518	76	relation	relation	NN
cord-304876-txaoz7oh	518	77	to	to	IN
cord-304876-txaoz7oh	518	78	VPg	VPg	NNP
cord-304876-txaoz7oh	518	79	uridylylation	uridylylation	NNP
cord-304876-txaoz7oh	518	80	Crystal	Crystal	NNP
cord-304876-txaoz7oh	518	81	structure	structure	NN
cord-304876-txaoz7oh	518	82	of	of	IN
cord-304876-txaoz7oh	518	83	complete	complete	JJ
cord-304876-txaoz7oh	518	84	rhinovirus	rhinovirus	NN
cord-304876-txaoz7oh	518	85	RNA	rna	NN
cord-304876-txaoz7oh	518	86	polymerase	polymerase	NN
cord-304876-txaoz7oh	518	87	suggests	suggest	VBZ
cord-304876-txaoz7oh	518	88	front	front	JJ
cord-304876-txaoz7oh	518	89	loading	loading	NN
cord-304876-txaoz7oh	518	90	of	of	IN
cord-304876-txaoz7oh	518	91	protein	protein	NN
cord-304876-txaoz7oh	518	92	primer	primer	NN
cord-304876-txaoz7oh	518	93	Crystal	Crystal	NNP
cord-304876-txaoz7oh	518	94	structure	structure	NN
cord-304876-txaoz7oh	518	95	of	of	IN
cord-304876-txaoz7oh	518	96	enterovirus	enterovirus	NN
cord-304876-txaoz7oh	518	97	71	71	CD
cord-304876-txaoz7oh	518	98	RNA	RNA	NNP
cord-304876-txaoz7oh	518	99	-	-	HYPH
cord-304876-txaoz7oh	518	100	dependent	dependent	JJ
cord-304876-txaoz7oh	518	101	RNA	RNA	NNP
cord-304876-txaoz7oh	518	102	polymerase	polymerase	NN
cord-304876-txaoz7oh	518	103	complexed	complexe	VBN
cord-304876-txaoz7oh	518	104	with	with	IN
cord-304876-txaoz7oh	518	105	its	-PRON-	PRP$
cord-304876-txaoz7oh	518	106	protein	protein	NN
cord-304876-txaoz7oh	518	107	primer	primer	NN
cord-304876-txaoz7oh	518	108	VPg	VPg	NNS
cord-304876-txaoz7oh	518	109	:	:	:
cord-304876-txaoz7oh	518	110	implication	implication	NN
cord-304876-txaoz7oh	518	111	for	for	IN
cord-304876-txaoz7oh	518	112	a	a	DT
cord-304876-txaoz7oh	518	113	trans	trans	JJ
cord-304876-txaoz7oh	518	114	mechanism	mechanism	NN
cord-304876-txaoz7oh	518	115	of	of	IN
cord-304876-txaoz7oh	518	116	VPg	VPg	NNP
cord-304876-txaoz7oh	518	117	uridylylation	uridylylation	NNP
cord-304876-txaoz7oh	519	1	Structural	structural	JJ
cord-304876-txaoz7oh	519	2	basis	basis	NN
cord-304876-txaoz7oh	519	3	for	for	IN
cord-304876-txaoz7oh	519	4	active	active	JJ
cord-304876-txaoz7oh	519	5	site	site	NN
cord-304876-txaoz7oh	519	6	closure	closure	NN
cord-304876-txaoz7oh	519	7	by	by	IN
cord-304876-txaoz7oh	519	8	the	the	DT
cord-304876-txaoz7oh	519	9	poliovirus	poliovirus	NN
cord-304876-txaoz7oh	519	10	RNA	rna	NN
cord-304876-txaoz7oh	519	11	-	-	HYPH
cord-304876-txaoz7oh	519	12	dependent	dependent	JJ
cord-304876-txaoz7oh	519	13	RNA	RNA	NNP
cord-304876-txaoz7oh	519	14	polymerase	polymerase	NN
cord-304876-txaoz7oh	519	15	Evolution	evolution	NN
cord-304876-txaoz7oh	519	16	of	of	IN
cord-304876-txaoz7oh	519	17	tertiary	tertiary	JJ
cord-304876-txaoz7oh	519	18	structure	structure	NN
cord-304876-txaoz7oh	519	19	of	of	IN
cord-304876-txaoz7oh	519	20	viral	viral	JJ
cord-304876-txaoz7oh	519	21	RNA	RNA	NNP
cord-304876-txaoz7oh	519	22	dependent	dependent	JJ
cord-304876-txaoz7oh	519	23	polymerases	polymerases	VBP
cord-304876-txaoz7oh	519	24	Structure	Structure	NNP
cord-304876-txaoz7oh	519	25	of	of	IN
cord-304876-txaoz7oh	519	26	the	the	DT
cord-304876-txaoz7oh	519	27	RNA	RNA	NNP
cord-304876-txaoz7oh	519	28	-	-	HYPH
cord-304876-txaoz7oh	519	29	dependent	dependent	JJ
cord-304876-txaoz7oh	519	30	RNA	RNA	NNP
cord-304876-txaoz7oh	519	31	polymerase	polymerase	NN
cord-304876-txaoz7oh	519	32	of	of	IN
cord-304876-txaoz7oh	519	33	poliovirus	poliovirus	NN
cord-304876-txaoz7oh	519	34	Identification	identification	NN
cord-304876-txaoz7oh	519	35	of	of	IN
cord-304876-txaoz7oh	519	36	four	four	CD
cord-304876-txaoz7oh	519	37	conserved	conserved	JJ
cord-304876-txaoz7oh	519	38	motifs	motif	NNS
cord-304876-txaoz7oh	519	39	among	among	IN
cord-304876-txaoz7oh	519	40	the	the	DT
cord-304876-txaoz7oh	519	41	RNA	rna	NN
cord-304876-txaoz7oh	519	42	-	-	HYPH
cord-304876-txaoz7oh	519	43	dependent	dependent	JJ
cord-304876-txaoz7oh	519	44	polymerase	polymerase	NN
cord-304876-txaoz7oh	519	45	encoding	encode	VBG
cord-304876-txaoz7oh	519	46	elements	element	NNS
cord-304876-txaoz7oh	519	47	Structural	structural	JJ
cord-304876-txaoz7oh	519	48	basis	basis	NN
cord-304876-txaoz7oh	519	49	for	for	IN
cord-304876-txaoz7oh	519	50	proteolysis	proteolysis	NN
cord-304876-txaoz7oh	519	51	-	-	HYPH
cord-304876-txaoz7oh	519	52	dependent	dependent	JJ
cord-304876-txaoz7oh	519	53	activation	activation	NN
cord-304876-txaoz7oh	519	54	of	of	IN
cord-304876-txaoz7oh	519	55	the	the	DT
cord-304876-txaoz7oh	519	56	poliovirus	poliovirus	NN
cord-304876-txaoz7oh	519	57	RNA	rna	NN
cord-304876-txaoz7oh	519	58	-	-	HYPH
cord-304876-txaoz7oh	519	59	dependent	dependent	JJ
cord-304876-txaoz7oh	519	60	RNA	RNA	NNP
cord-304876-txaoz7oh	519	61	polymerase	polymerase	NN
cord-304876-txaoz7oh	519	62	Poliovirus	Poliovirus	NNP
cord-304876-txaoz7oh	519	63	RNA	RNA	NNP
cord-304876-txaoz7oh	519	64	-	-	HYPH
cord-304876-txaoz7oh	519	65	dependent	dependent	JJ
cord-304876-txaoz7oh	519	66	RNA	RNA	NNP
cord-304876-txaoz7oh	519	67	polymerase	polymerase	NN
cord-304876-txaoz7oh	519	68	(	(	-LRB-
cord-304876-txaoz7oh	519	69	3Dpol	3dpol	NN
cord-304876-txaoz7oh	519	70	)	)	-RRB-
cord-304876-txaoz7oh	520	1	:	:	:
cord-304876-txaoz7oh	520	2	Structural	structural	JJ
cord-304876-txaoz7oh	520	3	,	,	,
cord-304876-txaoz7oh	520	4	biochemical	biochemical	JJ
cord-304876-txaoz7oh	520	5	,	,	,
cord-304876-txaoz7oh	520	6	and	and	CC
cord-304876-txaoz7oh	520	7	biological	biological	JJ
cord-304876-txaoz7oh	520	8	analysis	analysis	NN
cord-304876-txaoz7oh	520	9	of	of	IN
cord-304876-txaoz7oh	520	10	conserved	conserved	JJ
cord-304876-txaoz7oh	520	11	structural	structural	JJ
cord-304876-txaoz7oh	520	12	motifs	motif	NNS
cord-304876-txaoz7oh	520	13	A	a	NN
cord-304876-txaoz7oh	520	14	and	and	CC
cord-304876-txaoz7oh	520	15	B	B	NNP
cord-304876-txaoz7oh	520	16	Visualization	visualization	NN
cord-304876-txaoz7oh	520	17	and	and	CC
cord-304876-txaoz7oh	520	18	functional	functional	JJ
cord-304876-txaoz7oh	520	19	analysis	analysis	NN
cord-304876-txaoz7oh	520	20	of	of	IN
cord-304876-txaoz7oh	520	21	RNA	RNA	NNP
cord-304876-txaoz7oh	520	22	-	-	HYPH
cord-304876-txaoz7oh	520	23	dependent	dependent	JJ
cord-304876-txaoz7oh	520	24	RNA	RNA	NNP
cord-304876-txaoz7oh	520	25	polymerase	polymerase	NN
cord-304876-txaoz7oh	520	26	lattices	lattice	NNS
cord-304876-txaoz7oh	520	27	Surface	surface	VBP
cord-304876-txaoz7oh	520	28	for	for	IN
cord-304876-txaoz7oh	520	29	catalysis	catalysis	NN
cord-304876-txaoz7oh	520	30	by	by	IN
cord-304876-txaoz7oh	520	31	poliovirus	poliovirus	NN
cord-304876-txaoz7oh	520	32	RNA	RNA	NNP
cord-304876-txaoz7oh	520	33	-	-	HYPH
cord-304876-txaoz7oh	520	34	dependent	dependent	JJ
cord-304876-txaoz7oh	520	35	RNA	RNA	NNP
cord-304876-txaoz7oh	520	36	polymerase	polymerase	NN
cord-304876-txaoz7oh	520	37	Oligomeric	oligomeric	JJ
cord-304876-txaoz7oh	520	38	structures	structure	NNS
cord-304876-txaoz7oh	520	39	of	of	IN
cord-304876-txaoz7oh	520	40	poliovirus	poliovirus	NN
cord-304876-txaoz7oh	520	41	polymerase	polymerase	NN
cord-304876-txaoz7oh	520	42	are	be	VBP
cord-304876-txaoz7oh	520	43	important	important	JJ
cord-304876-txaoz7oh	520	44	for	for	IN
cord-304876-txaoz7oh	520	45	function	function	NN
cord-304876-txaoz7oh	521	1	Structurefunction	Structurefunction	NNP
cord-304876-txaoz7oh	521	2	relationships	relationship	NNS
cord-304876-txaoz7oh	521	3	of	of	IN
cord-304876-txaoz7oh	521	4	the	the	DT
cord-304876-txaoz7oh	521	5	RNA	RNA	NNP
cord-304876-txaoz7oh	521	6	-	-	HYPH
cord-304876-txaoz7oh	521	7	dependent	dependent	JJ
cord-304876-txaoz7oh	521	8	RNA	RNA	NNP
cord-304876-txaoz7oh	521	9	polymerase	polymerase	NN
cord-304876-txaoz7oh	521	10	from	from	IN
cord-304876-txaoz7oh	521	11	poliovirus	poliovirus	NN
cord-304876-txaoz7oh	521	12	(	(	-LRB-
cord-304876-txaoz7oh	521	13	3Dpol	3dpol	NN
cord-304876-txaoz7oh	521	14	)	)	-RRB-
cord-304876-txaoz7oh	522	1	A	a	DT
cord-304876-txaoz7oh	522	2	surface	surface	NN
cord-304876-txaoz7oh	522	3	of	of	IN
cord-304876-txaoz7oh	522	4	the	the	DT
cord-304876-txaoz7oh	522	5	primary	primary	JJ
cord-304876-txaoz7oh	522	6	oligomerization	oligomerization	NN
cord-304876-txaoz7oh	522	7	domain	domain	NN
cord-304876-txaoz7oh	522	8	functions	function	NNS
cord-304876-txaoz7oh	522	9	in	in	IN
cord-304876-txaoz7oh	522	10	capsid	capsid	JJ
cord-304876-txaoz7oh	522	11	precursor	precursor	NN
cord-304876-txaoz7oh	522	12	processing	processing	NN
cord-304876-txaoz7oh	522	13	and	and	CC
cord-304876-txaoz7oh	522	14	VPg	VPg	NNP
cord-304876-txaoz7oh	522	15	uridylylation	uridylylation	NN
cord-304876-txaoz7oh	523	1	Nidovirus	Nidovirus	NNP
cord-304876-txaoz7oh	523	2	RNA	RNA	NNP
cord-304876-txaoz7oh	523	3	polymerases	polymerase	NNS
cord-304876-txaoz7oh	523	4	:	:	:
cord-304876-txaoz7oh	524	1	Complex	complex	JJ
cord-304876-txaoz7oh	524	2	enzymes	enzyme	NNS
cord-304876-txaoz7oh	524	3	handling	handle	VBG
cord-304876-txaoz7oh	524	4	exceptional	exceptional	JJ
cord-304876-txaoz7oh	524	5	RNA	RNA	NNP
cord-304876-txaoz7oh	524	6	genomes	genome	NNS
cord-304876-txaoz7oh	524	7	Coronaviruses	Coronaviruses	NNP
cord-304876-txaoz7oh	524	8	post	post	NN
cord-304876-txaoz7oh	524	9	-	-	JJ
cord-304876-txaoz7oh	524	10	SARS	SARS	NNP
cord-304876-txaoz7oh	524	11	:	:	:
cord-304876-txaoz7oh	524	12	Update	update	VB
cord-304876-txaoz7oh	524	13	on	on	IN
cord-304876-txaoz7oh	524	14	replication	replication	NN
cord-304876-txaoz7oh	524	15	and	and	CC
cord-304876-txaoz7oh	524	16	pathogenesis	pathogenesis	NN
cord-304876-txaoz7oh	525	1	One	one	CD
cord-304876-txaoz7oh	525	2	severe	severe	JJ
cord-304876-txaoz7oh	525	3	acute	acute	JJ
cord-304876-txaoz7oh	525	4	respiratory	respiratory	JJ
cord-304876-txaoz7oh	525	5	syndrome	syndrome	NN
cord-304876-txaoz7oh	525	6	coronavirus	coronavirus	NN
cord-304876-txaoz7oh	525	7	protein	protein	NN
cord-304876-txaoz7oh	525	8	complex	complex	NN
cord-304876-txaoz7oh	525	9	integrates	integrate	VBZ
cord-304876-txaoz7oh	525	10	processive	processive	JJ
cord-304876-txaoz7oh	525	11	RNA	RNA	NNP
cord-304876-txaoz7oh	525	12	polymerase	polymerase	NN
cord-304876-txaoz7oh	525	13	and	and	CC
cord-304876-txaoz7oh	525	14	exonuclease	exonuclease	NN
cord-304876-txaoz7oh	525	15	activities	activity	NNS
cord-304876-txaoz7oh	525	16	Discovery	Discovery	NNP
cord-304876-txaoz7oh	525	17	of	of	IN
cord-304876-txaoz7oh	525	18	an	an	DT
cord-304876-txaoz7oh	525	19	essential	essential	JJ
cord-304876-txaoz7oh	525	20	nucleotidylating	nucleotidylate	VBG
cord-304876-txaoz7oh	525	21	activity	activity	NN
cord-304876-txaoz7oh	525	22	associated	associate	VBN
cord-304876-txaoz7oh	525	23	with	with	IN
cord-304876-txaoz7oh	525	24	a	a	DT
cord-304876-txaoz7oh	525	25	newly	newly	RB
cord-304876-txaoz7oh	525	26	delineated	delineate	VBN
cord-304876-txaoz7oh	525	27	conserved	conserved	JJ
cord-304876-txaoz7oh	525	28	domain	domain	NN
cord-304876-txaoz7oh	525	29	in	in	IN
cord-304876-txaoz7oh	525	30	the	the	DT
cord-304876-txaoz7oh	525	31	RNA	RNA	NNP
cord-304876-txaoz7oh	525	32	polymerase	polymerase	NN
cord-304876-txaoz7oh	525	33	-	-	HYPH
cord-304876-txaoz7oh	525	34	containing	contain	VBG
cord-304876-txaoz7oh	525	35	protein	protein	NN
cord-304876-txaoz7oh	525	36	of	of	IN
cord-304876-txaoz7oh	525	37	all	all	DT
cord-304876-txaoz7oh	525	38	nidoviruses	nidoviruses	NNP
cord-304876-txaoz7oh	525	39	Molecular	Molecular	NNP
cord-304876-txaoz7oh	525	40	model	model	NN
cord-304876-txaoz7oh	525	41	of	of	IN
cord-304876-txaoz7oh	525	42	SARS	SARS	NNP
cord-304876-txaoz7oh	525	43	coronavirus	coronavirus	NN
cord-304876-txaoz7oh	525	44	polymerase	polymerase	NN
cord-304876-txaoz7oh	525	45	:	:	:
cord-304876-txaoz7oh	525	46	implications	implication	NNS
cord-304876-txaoz7oh	525	47	for	for	IN
cord-304876-txaoz7oh	525	48	biochemical	biochemical	JJ
cord-304876-txaoz7oh	525	49	functions	function	NNS
cord-304876-txaoz7oh	525	50	and	and	CC
cord-304876-txaoz7oh	525	51	drug	drug	NN
cord-304876-txaoz7oh	525	52	design	design	NN
cord-304876-txaoz7oh	526	1	The	the	DT
cord-304876-txaoz7oh	526	2	palm	palm	NN
cord-304876-txaoz7oh	526	3	subdomain	subdomain	NN
cord-304876-txaoz7oh	526	4	-	-	HYPH
cord-304876-txaoz7oh	526	5	based	base	VBN
cord-304876-txaoz7oh	526	6	active	active	JJ
cord-304876-txaoz7oh	526	7	site	site	NN
cord-304876-txaoz7oh	526	8	is	be	VBZ
cord-304876-txaoz7oh	526	9	internally	internally	RB
cord-304876-txaoz7oh	526	10	permuted	permute	VBN
cord-304876-txaoz7oh	526	11	in	in	IN
cord-304876-txaoz7oh	526	12	viral	viral	JJ
cord-304876-txaoz7oh	526	13	RNA	RNA	NNP
cord-304876-txaoz7oh	526	14	-	-	HYPH
cord-304876-txaoz7oh	526	15	dependent	dependent	JJ
cord-304876-txaoz7oh	526	16	RNA	RNA	NNP
cord-304876-txaoz7oh	526	17	polymerases	polymerase	NNS
cord-304876-txaoz7oh	526	18	of	of	IN
cord-304876-txaoz7oh	526	19	an	an	DT
cord-304876-txaoz7oh	526	20	ancient	ancient	JJ
cord-304876-txaoz7oh	526	21	lineage	lineage	NN
cord-304876-txaoz7oh	526	22	Expression	expression	NN
cord-304876-txaoz7oh	526	23	,	,	,
cord-304876-txaoz7oh	526	24	purification	purification	NN
cord-304876-txaoz7oh	526	25	,	,	,
cord-304876-txaoz7oh	526	26	and	and	CC
cord-304876-txaoz7oh	526	27	characterization	characterization	NN
cord-304876-txaoz7oh	526	28	of	of	IN
cord-304876-txaoz7oh	526	29	SARS	SARS	NNP
cord-304876-txaoz7oh	526	30	coronavirus	coronavirus	NN
cord-304876-txaoz7oh	526	31	RNA	RNA	NNP
cord-304876-txaoz7oh	526	32	polymerase	polymerase	NN
cord-304876-txaoz7oh	526	33	Structural	structural	JJ
cord-304876-txaoz7oh	526	34	basis	basis	NN
cord-304876-txaoz7oh	526	35	and	and	CC
cord-304876-txaoz7oh	526	36	functional	functional	JJ
cord-304876-txaoz7oh	526	37	analysis	analysis	NN
cord-304876-txaoz7oh	526	38	of	of	IN
cord-304876-txaoz7oh	526	39	the	the	DT
cord-304876-txaoz7oh	526	40	SARS	SARS	NNP
cord-304876-txaoz7oh	526	41	coronavirus	coronavirus	NN
cord-304876-txaoz7oh	526	42	nsp14-nsp10	nsp14-nsp10	JJ
cord-304876-txaoz7oh	526	43	complex	complex	JJ
cord-304876-txaoz7oh	526	44	Design	design	NN
cord-304876-txaoz7oh	526	45	,	,	,
cord-304876-txaoz7oh	526	46	synthesis	synthesis	NN
cord-304876-txaoz7oh	526	47	,	,	,
cord-304876-txaoz7oh	526	48	and	and	CC
cord-304876-txaoz7oh	526	49	broad	broad	JJ
cord-304876-txaoz7oh	526	50	spectrum	spectrum	JJ
cord-304876-txaoz7oh	526	51	antiviral	antiviral	JJ
cord-304876-txaoz7oh	526	52	activity	activity	NN
cord-304876-txaoz7oh	526	53	of	of	IN
cord-304876-txaoz7oh	526	54	1-b	1-b	CD
cord-304876-txaoz7oh	526	55	-	-	HYPH
cord-304876-txaoz7oh	526	56	D	d	NN
cord-304876-txaoz7oh	526	57	-	-	HYPH
cord-304876-txaoz7oh	526	58	ribofuranosyl-1,2,4-triazole-3-carboxamide	ribofuranosyl-1,2,4-triazole-3-carboxamide	JJ
cord-304876-txaoz7oh	526	59	and	and	CC
cord-304876-txaoz7oh	526	60	related	related	JJ
cord-304876-txaoz7oh	526	61	nucleosides	nucleosides	NNP
cord-304876-txaoz7oh	526	62	Broad	Broad	NNP
cord-304876-txaoz7oh	526	63	-	-	HYPH
cord-304876-txaoz7oh	526	64	spectrum	spectrum	NN
cord-304876-txaoz7oh	526	65	antiviral	antiviral	JJ
cord-304876-txaoz7oh	526	66	activity	activity	NN
cord-304876-txaoz7oh	526	67	of	of	IN
cord-304876-txaoz7oh	526	68	Virazole	Virazole	NNP
cord-304876-txaoz7oh	526	69	:	:	:
cord-304876-txaoz7oh	526	70	1-beta	1-beta	CD
cord-304876-txaoz7oh	526	71	-	-	HYPH
cord-304876-txaoz7oh	526	72	D	d	NN
cord-304876-txaoz7oh	526	73	-	-	HYPH
cord-304876-txaoz7oh	526	74	ribofuranosyl-1,2,4-triazole-3-carboxamide	ribofuranosyl-1,2,4-triazole-3-carboxamide	JJ
cord-304876-txaoz7oh	526	75	Amantadine	Amantadine	NNP
cord-304876-txaoz7oh	526	76	and	and	CC
cord-304876-txaoz7oh	526	77	ribavirin	ribavirin	JJ
cord-304876-txaoz7oh	526	78	aerosol	aerosol	NN
cord-304876-txaoz7oh	526	79	treatment	treatment	NN
cord-304876-txaoz7oh	526	80	of	of	IN
cord-304876-txaoz7oh	526	81	influenza	influenza	NN
cord-304876-txaoz7oh	526	82	A	a	NN
cord-304876-txaoz7oh	526	83	and	and	CC
cord-304876-txaoz7oh	526	84	B	b	NN
cord-304876-txaoz7oh	526	85	infection	infection	NN
cord-304876-txaoz7oh	526	86	in	in	IN
cord-304876-txaoz7oh	526	87	mice	mouse	NNS
cord-304876-txaoz7oh	526	88	Protection	Protection	NNP
cord-304876-txaoz7oh	526	89	of	of	IN
cord-304876-txaoz7oh	526	90	mice	mouse	NNS
cord-304876-txaoz7oh	526	91	from	from	IN
cord-304876-txaoz7oh	526	92	lethal	lethal	JJ
cord-304876-txaoz7oh	526	93	influenza	influenza	NN
cord-304876-txaoz7oh	526	94	virus	virus	NN
cord-304876-txaoz7oh	526	95	infection	infection	NN
cord-304876-txaoz7oh	526	96	with	with	IN
cord-304876-txaoz7oh	526	97	high	high	JJ
cord-304876-txaoz7oh	526	98	dose	dose	NN
cord-304876-txaoz7oh	526	99	-	-	HYPH
cord-304876-txaoz7oh	526	100	short	short	JJ
cord-304876-txaoz7oh	526	101	duration	duration	NN
cord-304876-txaoz7oh	527	1	ribavirin	ribavirin	NNP
cord-304876-txaoz7oh	527	2	aerosol	aerosol	NNP
cord-304876-txaoz7oh	527	3	Ribavirin	ribavirin	NN
cord-304876-txaoz7oh	527	4	-	-	HYPH
cord-304876-txaoz7oh	527	5	current	current	JJ
cord-304876-txaoz7oh	527	6	status	status	NN
cord-304876-txaoz7oh	527	7	of	of	IN
cord-304876-txaoz7oh	527	8	a	a	DT
cord-304876-txaoz7oh	527	9	broad	broad	JJ
cord-304876-txaoz7oh	527	10	spectrum	spectrum	JJ
cord-304876-txaoz7oh	527	11	antiviral	antiviral	JJ
cord-304876-txaoz7oh	527	12	agent	agent	NN
cord-304876-txaoz7oh	527	13	Mechanism	Mechanism	NNP
cord-304876-txaoz7oh	527	14	of	of	IN
cord-304876-txaoz7oh	527	15	action	action	NN
cord-304876-txaoz7oh	527	16	of	of	IN
cord-304876-txaoz7oh	527	17	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	527	18	in	in	IN
cord-304876-txaoz7oh	527	19	the	the	DT
cord-304876-txaoz7oh	527	20	combination	combination	NN
cord-304876-txaoz7oh	527	21	treatment	treatment	NN
cord-304876-txaoz7oh	527	22	of	of	IN
cord-304876-txaoz7oh	527	23	chronic	chronic	JJ
cord-304876-txaoz7oh	527	24	HCV	HCV	NNP
cord-304876-txaoz7oh	527	25	infection	infection	NN
cord-304876-txaoz7oh	528	1	The	the	DT
cord-304876-txaoz7oh	528	2	broad	broad	JJ
cord-304876-txaoz7oh	528	3	-	-	HYPH
cord-304876-txaoz7oh	528	4	spectrum	spectrum	NN
cord-304876-txaoz7oh	528	5	antiviral	antiviral	JJ
cord-304876-txaoz7oh	528	6	ribonucleoside	ribonucleoside	NN
cord-304876-txaoz7oh	528	7	ribavirin	ribavirin	RB
cord-304876-txaoz7oh	528	8	is	be	VBZ
cord-304876-txaoz7oh	528	9	an	an	DT
cord-304876-txaoz7oh	528	10	RNA	RNA	NNP
cord-304876-txaoz7oh	528	11	virus	virus	NN
cord-304876-txaoz7oh	528	12	mutagen	mutagen	NN
cord-304876-txaoz7oh	528	13	2'-C	2'-c	CD
cord-304876-txaoz7oh	528	14	-	-	:
cord-304876-txaoz7oh	528	15	Methyl	methyl	NN
cord-304876-txaoz7oh	528	16	branched	branch	VBD
cord-304876-txaoz7oh	528	17	pyrimidine	pyrimidine	JJ
cord-304876-txaoz7oh	528	18	ribonucleoside	ribonucleoside	JJ
cord-304876-txaoz7oh	528	19	analogues	analogue	NNS
cord-304876-txaoz7oh	528	20	:	:	:
cord-304876-txaoz7oh	528	21	potent	potent	JJ
cord-304876-txaoz7oh	528	22	inhibitors	inhibitor	NNS
cord-304876-txaoz7oh	528	23	of	of	IN
cord-304876-txaoz7oh	528	24	RNA	RNA	NNP
cord-304876-txaoz7oh	528	25	virus	virus	NN
cord-304876-txaoz7oh	528	26	replication	replication	NN
cord-304876-txaoz7oh	528	27	Inhibition	inhibition	NN
cord-304876-txaoz7oh	528	28	of	of	IN
cord-304876-txaoz7oh	528	29	hepatitis	hepatitis	NN
cord-304876-txaoz7oh	528	30	C	C	NNP
cord-304876-txaoz7oh	528	31	virus	virus	NN
cord-304876-txaoz7oh	528	32	RNA	RNA	NNP
cord-304876-txaoz7oh	528	33	replication	replication	NN
cord-304876-txaoz7oh	528	34	by	by	IN
cord-304876-txaoz7oh	528	35	2'-modified	2'-modified	CD
cord-304876-txaoz7oh	528	36	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	528	37	analogs	analogs	NNP
cord-304876-txaoz7oh	528	38	Structure	structure	NN
cord-304876-txaoz7oh	528	39	-	-	HYPH
cord-304876-txaoz7oh	528	40	activity	activity	NN
cord-304876-txaoz7oh	528	41	relationship	relationship	NN
cord-304876-txaoz7oh	528	42	of	of	IN
cord-304876-txaoz7oh	528	43	heterobase	heterobase	NN
cord-304876-txaoz7oh	528	44	-	-	HYPH
cord-304876-txaoz7oh	528	45	modified	modify	VBN
cord-304876-txaoz7oh	528	46	2'-C	2'-c	CD
cord-304876-txaoz7oh	528	47	-	-	HYPH
cord-304876-txaoz7oh	528	48	methyl	methyl	NN
cord-304876-txaoz7oh	528	49	ribonucleosides	ribonucleoside	NNS
cord-304876-txaoz7oh	528	50	as	as	IN
cord-304876-txaoz7oh	528	51	inhibitors	inhibitor	NNS
cord-304876-txaoz7oh	528	52	of	of	IN
cord-304876-txaoz7oh	528	53	hepatitis	hepatitis	NNP
cord-304876-txaoz7oh	528	54	C	C	NNP
cord-304876-txaoz7oh	528	55	virus	virus	NN
cord-304876-txaoz7oh	528	56	RNA	RNA	NNP
cord-304876-txaoz7oh	528	57	replication	replication	NN
cord-304876-txaoz7oh	528	58	Efficacy	Efficacy	NNP
cord-304876-txaoz7oh	528	59	of	of	IN
cord-304876-txaoz7oh	528	60	2'-C	2'-c	CD
cord-304876-txaoz7oh	528	61	-	-	HYPH
cord-304876-txaoz7oh	528	62	methylcytidine	methylcytidine	NN
cord-304876-txaoz7oh	528	63	against	against	IN
cord-304876-txaoz7oh	528	64	yellow	yellow	JJ
cord-304876-txaoz7oh	528	65	fever	fever	NN
cord-304876-txaoz7oh	528	66	virus	virus	NN
cord-304876-txaoz7oh	528	67	in	in	IN
cord-304876-txaoz7oh	528	68	cell	cell	NN
cord-304876-txaoz7oh	528	69	culture	culture	NN
cord-304876-txaoz7oh	528	70	and	and	CC
cord-304876-txaoz7oh	528	71	in	in	IN
cord-304876-txaoz7oh	528	72	a	a	DT
cord-304876-txaoz7oh	528	73	hamster	hamster	NN
cord-304876-txaoz7oh	528	74	model	model	NN
cord-304876-txaoz7oh	528	75	A	a	DT
cord-304876-txaoz7oh	528	76	7-deazaadenosine	7-deazaadenosine	CD
cord-304876-txaoz7oh	528	77	analog	analog	NN
cord-304876-txaoz7oh	528	78	is	be	VBZ
cord-304876-txaoz7oh	528	79	a	a	DT
cord-304876-txaoz7oh	528	80	potent	potent	JJ
cord-304876-txaoz7oh	528	81	and	and	CC
cord-304876-txaoz7oh	528	82	selective	selective	JJ
cord-304876-txaoz7oh	528	83	inhibitor	inhibitor	NN
cord-304876-txaoz7oh	528	84	of	of	IN
cord-304876-txaoz7oh	528	85	hepatitis	hepatitis	NN
cord-304876-txaoz7oh	528	86	C	C	NNP
cord-304876-txaoz7oh	528	87	virus	virus	NN
cord-304876-txaoz7oh	528	88	replication	replication	NN
cord-304876-txaoz7oh	528	89	with	with	IN
cord-304876-txaoz7oh	528	90	excellent	excellent	JJ
cord-304876-txaoz7oh	528	91	pharmacokinetic	pharmacokinetic	JJ
cord-304876-txaoz7oh	528	92	properties	property	NNS
cord-304876-txaoz7oh	529	1	A	a	DT
cord-304876-txaoz7oh	529	2	dengue	dengue	NN
cord-304876-txaoz7oh	529	3	fever	fever	NN
cord-304876-txaoz7oh	529	4	viremia	viremia	NN
cord-304876-txaoz7oh	529	5	model	model	NN
cord-304876-txaoz7oh	529	6	in	in	IN
cord-304876-txaoz7oh	529	7	mice	mouse	NNS
cord-304876-txaoz7oh	529	8	shows	show	VBZ
cord-304876-txaoz7oh	529	9	reduction	reduction	NN
cord-304876-txaoz7oh	529	10	in	in	IN
cord-304876-txaoz7oh	529	11	viral	viral	JJ
cord-304876-txaoz7oh	529	12	replication	replication	NN
cord-304876-txaoz7oh	529	13	and	and	CC
cord-304876-txaoz7oh	529	14	suppression	suppression	NN
cord-304876-txaoz7oh	529	15	of	of	IN
cord-304876-txaoz7oh	529	16	the	the	DT
cord-304876-txaoz7oh	529	17	inflammatory	inflammatory	JJ
cord-304876-txaoz7oh	529	18	response	response	NN
cord-304876-txaoz7oh	529	19	after	after	IN
cord-304876-txaoz7oh	529	20	treatment	treatment	NN
cord-304876-txaoz7oh	529	21	with	with	IN
cord-304876-txaoz7oh	529	22	antiviral	antiviral	JJ
cord-304876-txaoz7oh	529	23	drugs	drug	NNS
cord-304876-txaoz7oh	529	24	Synthesis	Synthesis	NNP
cord-304876-txaoz7oh	529	25	and	and	CC
cord-304876-txaoz7oh	529	26	pharmacokinetics	pharmacokinetic	NNS
cord-304876-txaoz7oh	529	27	of	of	IN
cord-304876-txaoz7oh	529	28	valopicitabine	valopicitabine	NNP
cord-304876-txaoz7oh	529	29	(	(	-LRB-
cord-304876-txaoz7oh	529	30	NM283	NM283	NNP
cord-304876-txaoz7oh	529	31	)	)	-RRB-
cord-304876-txaoz7oh	529	32	,	,	,
cord-304876-txaoz7oh	529	33	an	an	DT
cord-304876-txaoz7oh	529	34	efficient	efficient	JJ
cord-304876-txaoz7oh	529	35	prodrug	prodrug	NN
cord-304876-txaoz7oh	529	36	of	of	IN
cord-304876-txaoz7oh	529	37	the	the	DT
cord-304876-txaoz7oh	529	38	potent	potent	JJ
cord-304876-txaoz7oh	529	39	anti	anti	JJ
cord-304876-txaoz7oh	529	40	-	-	JJ
cord-304876-txaoz7oh	529	41	HCV	HCV	NNP
cord-304876-txaoz7oh	529	42	agent	agent	NN
cord-304876-txaoz7oh	529	43	2	2	CD
cord-304876-txaoz7oh	529	44	0	0	CD
cord-304876-txaoz7oh	529	45	-C	-C	:
cord-304876-txaoz7oh	529	46	-	-	HYPH
cord-304876-txaoz7oh	529	47	methylcytidine	methylcytidine	NN
cord-304876-txaoz7oh	529	48	Robust	robust	JJ
cord-304876-txaoz7oh	529	49	antiviral	antiviral	JJ
cord-304876-txaoz7oh	529	50	efficacy	efficacy	NN
cord-304876-txaoz7oh	529	51	upon	upon	IN
cord-304876-txaoz7oh	529	52	administration	administration	NN
cord-304876-txaoz7oh	529	53	of	of	IN
cord-304876-txaoz7oh	529	54	a	a	DT
cord-304876-txaoz7oh	529	55	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	529	56	analog	analog	NN
cord-304876-txaoz7oh	529	57	to	to	IN
cord-304876-txaoz7oh	529	58	hepatitis	hepatitis	NN
cord-304876-txaoz7oh	529	59	C	C	NNP
cord-304876-txaoz7oh	529	60	virus	virus	NN
cord-304876-txaoz7oh	529	61	-	-	HYPH
cord-304876-txaoz7oh	529	62	infected	infect	VBN
cord-304876-txaoz7oh	529	63	chimpanzees	chimpanzee	NNS
cord-304876-txaoz7oh	530	1	Multiple	multiple	JJ
cord-304876-txaoz7oh	530	2	classes	class	NNS
cord-304876-txaoz7oh	530	3	of	of	IN
cord-304876-txaoz7oh	530	4	antiviral	antiviral	JJ
cord-304876-txaoz7oh	530	5	agents	agent	NNS
cord-304876-txaoz7oh	530	6	exhibit	exhibit	VBP
cord-304876-txaoz7oh	530	7	in	in	IN
cord-304876-txaoz7oh	530	8	vitro	vitro	FW
cord-304876-txaoz7oh	530	9	activity	activity	NN
cord-304876-txaoz7oh	530	10	against	against	IN
cord-304876-txaoz7oh	530	11	human	human	JJ
cord-304876-txaoz7oh	530	12	rhinovirus	rhinovirus	NN
cord-304876-txaoz7oh	530	13	type	type	NN
cord-304876-txaoz7oh	530	14	C	C	NNP
cord-304876-txaoz7oh	530	15	An	An	NNP
cord-304876-txaoz7oh	530	16	adenosine	adenosine	NN
cord-304876-txaoz7oh	530	17	nucleoside	nucleoside	JJ
cord-304876-txaoz7oh	530	18	inhibitor	inhibitor	NN
cord-304876-txaoz7oh	530	19	of	of	IN
cord-304876-txaoz7oh	530	20	dengue	dengue	NN
cord-304876-txaoz7oh	530	21	virus	virus	NN
cord-304876-txaoz7oh	530	22	Biochemical	biochemical	JJ
cord-304876-txaoz7oh	530	23	characterization	characterization	NN
cord-304876-txaoz7oh	530	24	of	of	IN
cord-304876-txaoz7oh	530	25	the	the	DT
cord-304876-txaoz7oh	530	26	inhibition	inhibition	NN
cord-304876-txaoz7oh	530	27	of	of	IN
cord-304876-txaoz7oh	530	28	the	the	DT
cord-304876-txaoz7oh	530	29	dengue	dengue	NN
cord-304876-txaoz7oh	530	30	virus	virus	NN
cord-304876-txaoz7oh	530	31	RNA	rna	NN
cord-304876-txaoz7oh	530	32	polymerase	polymerase	NN
cord-304876-txaoz7oh	530	33	by	by	IN
cord-304876-txaoz7oh	530	34	beta	beta	NN
cord-304876-txaoz7oh	530	35	-	-	HYPH
cord-304876-txaoz7oh	530	36	D-2'-ethynyl-7-deazaadenosine	d-2'-ethynyl-7-deazaadenosine	JJ
cord-304876-txaoz7oh	530	37	triphosphate	triphosphate	NN
cord-304876-txaoz7oh	531	1	An	an	DT
cord-304876-txaoz7oh	531	2	adenosine	adenosine	NN
cord-304876-txaoz7oh	531	3	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	531	4	analogue	analogue	NN
cord-304876-txaoz7oh	531	5	NITD008	NITD008	NNP
cord-304876-txaoz7oh	531	6	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	531	7	EV71	EV71	NNP
cord-304876-txaoz7oh	531	8	proliferation	proliferation	NN
cord-304876-txaoz7oh	531	9	Inhibition	inhibition	NN
cord-304876-txaoz7oh	531	10	of	of	IN
cord-304876-txaoz7oh	531	11	enterovirus	enterovirus	NN
cord-304876-txaoz7oh	531	12	71	71	CD
cord-304876-txaoz7oh	531	13	by	by	IN
cord-304876-txaoz7oh	531	14	adenosine	adenosine	NN
cord-304876-txaoz7oh	531	15	analog	analog	NN
cord-304876-txaoz7oh	532	1	NITD008	NITD008	NNP
cord-304876-txaoz7oh	533	1	Fluorinated	fluorinated	JJ
cord-304876-txaoz7oh	533	2	nucleosides	nucleoside	NNS
cord-304876-txaoz7oh	533	3	as	as	IN
cord-304876-txaoz7oh	533	4	antiviral	antiviral	JJ
cord-304876-txaoz7oh	533	5	and	and	CC
cord-304876-txaoz7oh	533	6	antitumor	antitumor	JJ
cord-304876-txaoz7oh	533	7	agents	agent	NNS
cord-304876-txaoz7oh	533	8	Purine	Purine	NNP
cord-304876-txaoz7oh	533	9	2'-deoxy-2'-fluororibosides	2'-deoxy-2'-fluororibosides	CD
cord-304876-txaoz7oh	534	1	as	as	IN
cord-304876-txaoz7oh	534	2	antiinfluenza	antiinfluenza	NNP
cord-304876-txaoz7oh	534	3	virus	virus	NN
cord-304876-txaoz7oh	534	4	agents	agent	NNS
cord-304876-txaoz7oh	534	5	Efficacy	Efficacy	NNP
cord-304876-txaoz7oh	534	6	of	of	IN
cord-304876-txaoz7oh	534	7	2'-deoxy-2'-fluororibosides	2'-deoxy-2'-fluororibosides	CD
cord-304876-txaoz7oh	534	8	against	against	IN
cord-304876-txaoz7oh	534	9	influenza	influenza	NN
cord-304876-txaoz7oh	534	10	A	a	NN
cord-304876-txaoz7oh	534	11	and	and	CC
cord-304876-txaoz7oh	534	12	B	b	NN
cord-304876-txaoz7oh	534	13	viruses	virus	NNS
cord-304876-txaoz7oh	534	14	in	in	IN
cord-304876-txaoz7oh	534	15	ferrets	ferret	NNS
cord-304876-txaoz7oh	534	16	Inhibition	inhibition	NN
cord-304876-txaoz7oh	534	17	of	of	IN
cord-304876-txaoz7oh	534	18	influenza	influenza	NN
cord-304876-txaoz7oh	534	19	virus	virus	NN
cord-304876-txaoz7oh	534	20	transcription	transcription	NN
cord-304876-txaoz7oh	534	21	by	by	IN
cord-304876-txaoz7oh	534	22	2'-deoxy-2'-fluoroguanosine	2'-deoxy-2'-fluoroguanosine	CD
cord-304876-txaoz7oh	535	1	In	in	IN
cord-304876-txaoz7oh	535	2	vitro	vitro	FW
cord-304876-txaoz7oh	535	3	and	and	CC
cord-304876-txaoz7oh	535	4	in	in	IN
cord-304876-txaoz7oh	535	5	vivo	vivo	NNP
cord-304876-txaoz7oh	535	6	efficacy	efficacy	NN
cord-304876-txaoz7oh	535	7	of	of	IN
cord-304876-txaoz7oh	535	8	fluorodeoxycytidine	fluorodeoxycytidine	JJ
cord-304876-txaoz7oh	535	9	analogs	analog	NNS
cord-304876-txaoz7oh	535	10	against	against	IN
cord-304876-txaoz7oh	535	11	highly	highly	RB
cord-304876-txaoz7oh	535	12	pathogenic	pathogenic	JJ
cord-304876-txaoz7oh	535	13	avian	avian	JJ
cord-304876-txaoz7oh	535	14	influenza	influenza	NN
cord-304876-txaoz7oh	535	15	H5N1	H5N1	NNP
cord-304876-txaoz7oh	535	16	,	,	,
cord-304876-txaoz7oh	535	17	seasonal	seasonal	JJ
cord-304876-txaoz7oh	535	18	,	,	,
cord-304876-txaoz7oh	535	19	and	and	CC
cord-304876-txaoz7oh	535	20	pandemic	pandemic	NN
cord-304876-txaoz7oh	535	21	H1N1	H1N1	NNP
cord-304876-txaoz7oh	535	22	virus	virus	NN
cord-304876-txaoz7oh	535	23	infections	infection	NNS
cord-304876-txaoz7oh	535	24	Phosphorylation	Phosphorylation	NNP
cord-304876-txaoz7oh	535	25	of	of	IN
cord-304876-txaoz7oh	535	26	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	535	27	and	and	CC
cord-304876-txaoz7oh	535	28	viramidine	viramidine	NN
cord-304876-txaoz7oh	535	29	by	by	IN
cord-304876-txaoz7oh	535	30	adenosine	adenosine	NN
cord-304876-txaoz7oh	535	31	kinase	kinase	NN
cord-304876-txaoz7oh	535	32	and	and	CC
cord-304876-txaoz7oh	535	33	cytosolic	cytosolic	JJ
cord-304876-txaoz7oh	535	34	5'-nucleotidase	5'-nucleotidase	CD
cord-304876-txaoz7oh	535	35	II	ii	NN
cord-304876-txaoz7oh	535	36	:	:	:
cord-304876-txaoz7oh	535	37	Implications	implication	NNS
cord-304876-txaoz7oh	535	38	for	for	IN
cord-304876-txaoz7oh	535	39	ribavirin	ribavirin	JJ
cord-304876-txaoz7oh	535	40	metabolism	metabolism	NN
cord-304876-txaoz7oh	535	41	in	in	IN
cord-304876-txaoz7oh	535	42	erythrocytes	erythrocyte	NNS
cord-304876-txaoz7oh	535	43	Synthesis	synthesis	NN
cord-304876-txaoz7oh	535	44	and	and	CC
cord-304876-txaoz7oh	535	45	anti	anti	JJ
cord-304876-txaoz7oh	535	46	-	-	JJ
cord-304876-txaoz7oh	535	47	viral	viral	JJ
cord-304876-txaoz7oh	535	48	activity	activity	NN
cord-304876-txaoz7oh	535	49	of	of	IN
cord-304876-txaoz7oh	535	50	a	a	DT
cord-304876-txaoz7oh	535	51	series	series	NN
cord-304876-txaoz7oh	535	52	of	of	IN
cord-304876-txaoz7oh	535	53	D	D	NNP
cord-304876-txaoz7oh	535	54	-	-	:
cord-304876-txaoz7oh	535	55	and	and	CC
cord-304876-txaoz7oh	535	56	L-2'-deoxy-2'-fluororibonucleosides	l-2'-deoxy-2'-fluororibonucleoside	NNS
cord-304876-txaoz7oh	535	57	in	in	IN
cord-304876-txaoz7oh	535	58	the	the	DT
cord-304876-txaoz7oh	535	59	subgenomic	subgenomic	JJ
cord-304876-txaoz7oh	535	60	HCV	HCV	NNP
cord-304876-txaoz7oh	535	61	replicon	replicon	NN
cord-304876-txaoz7oh	535	62	system	system	NN
cord-304876-txaoz7oh	535	63	Inhibition	Inhibition	NNP
cord-304876-txaoz7oh	535	64	of	of	IN
cord-304876-txaoz7oh	535	65	the	the	DT
cord-304876-txaoz7oh	535	66	subgenomic	subgenomic	NNP
cord-304876-txaoz7oh	535	67	hepatitis	hepatitis	NNP
cord-304876-txaoz7oh	535	68	C	C	NNP
cord-304876-txaoz7oh	535	69	virus	virus	NN
cord-304876-txaoz7oh	535	70	replicon	replicon	NN
cord-304876-txaoz7oh	535	71	in	in	IN
cord-304876-txaoz7oh	535	72	huh-7	huh-7	NNP
cord-304876-txaoz7oh	535	73	cells	cell	NNS
cord-304876-txaoz7oh	535	74	by	by	IN
cord-304876-txaoz7oh	535	75	2'-deoxy-2'-fluorocytidine	2'-deoxy-2'-fluorocytidine	CD
cord-304876-txaoz7oh	535	76	Efficiency	Efficiency	NNP
cord-304876-txaoz7oh	535	77	of	of	IN
cord-304876-txaoz7oh	535	78	incorporation	incorporation	NN
cord-304876-txaoz7oh	535	79	and	and	CC
cord-304876-txaoz7oh	535	80	chain	chain	NN
cord-304876-txaoz7oh	535	81	termination	termination	NN
cord-304876-txaoz7oh	535	82	determines	determine	VBZ
cord-304876-txaoz7oh	535	83	the	the	DT
cord-304876-txaoz7oh	535	84	inhibition	inhibition	NN
cord-304876-txaoz7oh	535	85	potency	potency	NN
cord-304876-txaoz7oh	535	86	of	of	IN
cord-304876-txaoz7oh	535	87	2'-modified	2'-modified	CD
cord-304876-txaoz7oh	535	88	nucleotide	nucleotide	JJ
cord-304876-txaoz7oh	535	89	analogs	analog	NNS
cord-304876-txaoz7oh	535	90	against	against	IN
cord-304876-txaoz7oh	535	91	hepatitis	hepatitis	NN
cord-304876-txaoz7oh	535	92	C	C	NNP
cord-304876-txaoz7oh	535	93	virus	virus	NN
cord-304876-txaoz7oh	535	94	polymerase	polymerase	NN
cord-304876-txaoz7oh	536	1	The	the	DT
cord-304876-txaoz7oh	536	2	effect	effect	NN
cord-304876-txaoz7oh	536	3	of	of	IN
cord-304876-txaoz7oh	536	4	2'-fluoro-2'-deoxycytidine	2'-fluoro-2'-deoxycytidine	CD
cord-304876-txaoz7oh	536	5	on	on	IN
cord-304876-txaoz7oh	536	6	herpes	herpes	NN
cord-304876-txaoz7oh	536	7	virus	virus	NN
cord-304876-txaoz7oh	536	8	growth	growth	NN
cord-304876-txaoz7oh	536	9	Polymerization	Polymerization	NNP
cord-304876-txaoz7oh	536	10	of	of	IN
cord-304876-txaoz7oh	536	11	2'-fluoro	2'-fluoro	CD
cord-304876-txaoz7oh	536	12	-	-	:
cord-304876-txaoz7oh	536	13	and	and	CC
cord-304876-txaoz7oh	536	14	2'-O	2'-o	CD
cord-304876-txaoz7oh	536	15	-	-	HYPH
cord-304876-txaoz7oh	536	16	methyl	methyl	NN
cord-304876-txaoz7oh	536	17	-	-	HYPH
cord-304876-txaoz7oh	536	18	dNTPs	dNTPs	NNP
cord-304876-txaoz7oh	536	19	by	by	IN
cord-304876-txaoz7oh	536	20	human	human	JJ
cord-304876-txaoz7oh	536	21	DNA	dna	NN
cord-304876-txaoz7oh	536	22	polymerase	polymerase	NN
cord-304876-txaoz7oh	536	23	alpha	alpha	NN
cord-304876-txaoz7oh	536	24	,	,	,
cord-304876-txaoz7oh	536	25	polymerase	polymerase	NN
cord-304876-txaoz7oh	536	26	gamma	gamma	NN
cord-304876-txaoz7oh	536	27	,	,	,
cord-304876-txaoz7oh	536	28	and	and	CC
cord-304876-txaoz7oh	536	29	primase	primase	VB
cord-304876-txaoz7oh	536	30	An	an	DT
cord-304876-txaoz7oh	536	31	evaluation	evaluation	NN
cord-304876-txaoz7oh	536	32	of	of	IN
cord-304876-txaoz7oh	536	33	the	the	DT
cord-304876-txaoz7oh	536	34	toxicities	toxicity	NNS
cord-304876-txaoz7oh	536	35	of	of	IN
cord-304876-txaoz7oh	536	36	2'-fluorouridine	2'-fluorouridine	CD
cord-304876-txaoz7oh	536	37	and	and	CC
cord-304876-txaoz7oh	536	38	2'-fluorocytidine	2'-fluorocytidine	CD
cord-304876-txaoz7oh	536	39	-	-	HYPH
cord-304876-txaoz7oh	536	40	HCl	hcl	NN
cord-304876-txaoz7oh	536	41	in	in	IN
cord-304876-txaoz7oh	536	42	F344	F344	NNS
cord-304876-txaoz7oh	536	43	rats	rat	NNS
cord-304876-txaoz7oh	536	44	and	and	CC
cord-304876-txaoz7oh	536	45	woodchucks	woodchuck	NNS
cord-304876-txaoz7oh	536	46	(	(	-LRB-
cord-304876-txaoz7oh	536	47	Marmota	Marmota	NNP
cord-304876-txaoz7oh	536	48	monax	monax	NNP
cord-304876-txaoz7oh	536	49	)	)	-RRB-
cord-304876-txaoz7oh	537	1	In	in	IN
cord-304876-txaoz7oh	537	2	vitro	vitro	FW
cord-304876-txaoz7oh	537	3	and	and	CC
cord-304876-txaoz7oh	537	4	in	in	IN
cord-304876-txaoz7oh	537	5	vivo	vivo	NN
cord-304876-txaoz7oh	537	6	activities	activity	NNS
cord-304876-txaoz7oh	537	7	of	of	IN
cord-304876-txaoz7oh	537	8	anti	anti	JJ
cord-304876-txaoz7oh	537	9	-	-	JJ
cord-304876-txaoz7oh	537	10	influenza	influenza	JJ
cord-304876-txaoz7oh	537	11	virus	virus	NN
cord-304876-txaoz7oh	537	12	compound	compound	NN
cord-304876-txaoz7oh	537	13	T-705	t-705	NN
cord-304876-txaoz7oh	537	14	Efficacy	Efficacy	NNP
cord-304876-txaoz7oh	537	15	of	of	IN
cord-304876-txaoz7oh	537	16	orally	orally	RB
cord-304876-txaoz7oh	537	17	administered	administer	VBN
cord-304876-txaoz7oh	537	18	T-705	t-705	NN
cord-304876-txaoz7oh	537	19	on	on	IN
cord-304876-txaoz7oh	537	20	lethal	lethal	JJ
cord-304876-txaoz7oh	537	21	avian	avian	JJ
cord-304876-txaoz7oh	537	22	influenza	influenza	NN
cord-304876-txaoz7oh	537	23	A	a	NN
cord-304876-txaoz7oh	537	24	(	(	-LRB-
cord-304876-txaoz7oh	537	25	H5N1	H5N1	NNP
cord-304876-txaoz7oh	537	26	)	)	-RRB-
cord-304876-txaoz7oh	537	27	virus	virus	NN
cord-304876-txaoz7oh	537	28	infections	infection	NNS
cord-304876-txaoz7oh	537	29	in	in	IN
cord-304876-txaoz7oh	537	30	mice	mouse	NNS
cord-304876-txaoz7oh	537	31	Mechanism	Mechanism	NNP
cord-304876-txaoz7oh	537	32	of	of	IN
cord-304876-txaoz7oh	537	33	action	action	NN
cord-304876-txaoz7oh	537	34	of	of	IN
cord-304876-txaoz7oh	537	35	T-705	t-705	NN
cord-304876-txaoz7oh	537	36	against	against	IN
cord-304876-txaoz7oh	537	37	influenza	influenza	NNP
cord-304876-txaoz7oh	537	38	virus	virus	NNP
cord-304876-txaoz7oh	537	39	T-705	T-705	NNP
cord-304876-txaoz7oh	537	40	(	(	-LRB-
cord-304876-txaoz7oh	537	41	favipiravir	favipiravir	NNP
cord-304876-txaoz7oh	537	42	)	)	-RRB-
cord-304876-txaoz7oh	537	43	and	and	CC
cord-304876-txaoz7oh	537	44	related	related	JJ
cord-304876-txaoz7oh	537	45	compounds	compound	NNS
cord-304876-txaoz7oh	537	46	:	:	:
cord-304876-txaoz7oh	537	47	Novel	novel	JJ
cord-304876-txaoz7oh	537	48	broad	broad	JJ
cord-304876-txaoz7oh	537	49	-	-	HYPH
cord-304876-txaoz7oh	537	50	spectrum	spectrum	NN
cord-304876-txaoz7oh	537	51	inhibitors	inhibitor	NNS
cord-304876-txaoz7oh	537	52	of	of	IN
cord-304876-txaoz7oh	537	53	RNA	RNA	NNP
cord-304876-txaoz7oh	537	54	viral	viral	JJ
cord-304876-txaoz7oh	537	55	infections	infection	NNS
cord-304876-txaoz7oh	537	56	T-705	T-705	NNS
cord-304876-txaoz7oh	537	57	(	(	-LRB-
cord-304876-txaoz7oh	537	58	Favipiravir	Favipiravir	NNP
cord-304876-txaoz7oh	537	59	)	)	-RRB-
cord-304876-txaoz7oh	537	60	induces	induce	VBZ
cord-304876-txaoz7oh	537	61	lethal	lethal	JJ
cord-304876-txaoz7oh	537	62	mutagenesis	mutagenesis	NN
cord-304876-txaoz7oh	537	63	in	in	IN
cord-304876-txaoz7oh	537	64	influenza	influenza	NN
cord-304876-txaoz7oh	537	65	A	a	DT
cord-304876-txaoz7oh	537	66	H1N1	H1N1	NNP
cord-304876-txaoz7oh	537	67	viruses	virus	NNS
cord-304876-txaoz7oh	537	68	in	in	IN
cord-304876-txaoz7oh	537	69	vitro	vitro	FW
cord-304876-txaoz7oh	537	70	The	the	DT
cord-304876-txaoz7oh	537	71	ambiguous	ambiguous	JJ
cord-304876-txaoz7oh	537	72	base	base	NN
cord-304876-txaoz7oh	537	73	-	-	HYPH
cord-304876-txaoz7oh	537	74	pairing	pair	VBG
cord-304876-txaoz7oh	537	75	and	and	CC
cord-304876-txaoz7oh	537	76	high	high	JJ
cord-304876-txaoz7oh	537	77	substrate	substrate	NN
cord-304876-txaoz7oh	537	78	efficiency	efficiency	NN
cord-304876-txaoz7oh	537	79	of	of	IN
cord-304876-txaoz7oh	538	1	T-705	T-705	NNP
cord-304876-txaoz7oh	538	2	(	(	-LRB-
cord-304876-txaoz7oh	538	3	Favipiravir	Favipiravir	NNP
cord-304876-txaoz7oh	538	4	)	)	-RRB-
cord-304876-txaoz7oh	538	5	Ribofuranosyl	Ribofuranosyl	NNP
cord-304876-txaoz7oh	539	1	5'-triphosphate	5'-triphosphate	JJ
cord-304876-txaoz7oh	539	2	towards	towards	IN
cord-304876-txaoz7oh	539	3	influenza	influenza	NN
cord-304876-txaoz7oh	539	4	A	a	DT
cord-304876-txaoz7oh	539	5	virus	virus	NN
cord-304876-txaoz7oh	539	6	polymerase	polymerase	NN
cord-304876-txaoz7oh	539	7	Successful	successful	JJ
cord-304876-txaoz7oh	539	8	treatment	treatment	NN
cord-304876-txaoz7oh	539	9	of	of	IN
cord-304876-txaoz7oh	539	10	advanced	advanced	JJ
cord-304876-txaoz7oh	539	11	Ebola	Ebola	NNP
cord-304876-txaoz7oh	539	12	virus	virus	NN
cord-304876-txaoz7oh	539	13	infection	infection	NN
cord-304876-txaoz7oh	539	14	with	with	IN
cord-304876-txaoz7oh	539	15	T-705	T-705	NNS
cord-304876-txaoz7oh	539	16	(	(	-LRB-
cord-304876-txaoz7oh	539	17	favipiravir	favipiravir	NNP
cord-304876-txaoz7oh	539	18	)	)	-RRB-
cord-304876-txaoz7oh	539	19	in	in	IN
cord-304876-txaoz7oh	539	20	a	a	DT
cord-304876-txaoz7oh	539	21	small	small	JJ
cord-304876-txaoz7oh	539	22	animal	animal	NN
cord-304876-txaoz7oh	539	23	model	model	NN
cord-304876-txaoz7oh	539	24	Post	post	NN
cord-304876-txaoz7oh	539	25	-	-	JJ
cord-304876-txaoz7oh	539	26	exposure	exposure	JJ
cord-304876-txaoz7oh	539	27	efficacy	efficacy	NN
cord-304876-txaoz7oh	539	28	of	of	IN
cord-304876-txaoz7oh	539	29	Oral	oral	JJ
cord-304876-txaoz7oh	539	30	T-705	T-705	NNS
cord-304876-txaoz7oh	539	31	(	(	-LRB-
cord-304876-txaoz7oh	539	32	Favipiravir	Favipiravir	NNP
cord-304876-txaoz7oh	539	33	)	)	-RRB-
cord-304876-txaoz7oh	539	34	against	against	IN
cord-304876-txaoz7oh	539	35	inhalational	inhalational	JJ
cord-304876-txaoz7oh	539	36	Ebola	Ebola	NNP
cord-304876-txaoz7oh	539	37	virus	virus	NN
cord-304876-txaoz7oh	539	38	infection	infection	NN
cord-304876-txaoz7oh	539	39	in	in	IN
cord-304876-txaoz7oh	539	40	a	a	DT
cord-304876-txaoz7oh	539	41	mouse	mouse	NN
cord-304876-txaoz7oh	539	42	model	model	NN
cord-304876-txaoz7oh	539	43	Treatment	treatment	NN
cord-304876-txaoz7oh	539	44	of	of	IN
cord-304876-txaoz7oh	539	45	late	late	JJ
cord-304876-txaoz7oh	539	46	stage	stage	NN
cord-304876-txaoz7oh	539	47	disease	disease	NN
cord-304876-txaoz7oh	539	48	in	in	IN
cord-304876-txaoz7oh	539	49	a	a	DT
cord-304876-txaoz7oh	539	50	model	model	NN
cord-304876-txaoz7oh	539	51	of	of	IN
cord-304876-txaoz7oh	539	52	arenaviral	arenaviral	JJ
cord-304876-txaoz7oh	539	53	hemorrhagic	hemorrhagic	JJ
cord-304876-txaoz7oh	539	54	fever	fever	NN
cord-304876-txaoz7oh	539	55	:	:	:
cord-304876-txaoz7oh	539	56	T-705	t-705	NN
cord-304876-txaoz7oh	539	57	efficacy	efficacy	NN
cord-304876-txaoz7oh	539	58	and	and	CC
cord-304876-txaoz7oh	539	59	reduced	reduce	VBN
cord-304876-txaoz7oh	539	60	toxicity	toxicity	NN
cord-304876-txaoz7oh	539	61	suggests	suggest	VBZ
cord-304876-txaoz7oh	539	62	an	an	DT
cord-304876-txaoz7oh	539	63	alternative	alternative	NN
cord-304876-txaoz7oh	539	64	to	to	IN
cord-304876-txaoz7oh	539	65	ribavirin	ribavirin	NN
cord-304876-txaoz7oh	540	1	In	in	IN
cord-304876-txaoz7oh	540	2	vitro	vitro	FW
cord-304876-txaoz7oh	540	3	and	and	CC
cord-304876-txaoz7oh	540	4	in	in	IN
cord-304876-txaoz7oh	540	5	vivo	vivo	NN
cord-304876-txaoz7oh	540	6	activities	activity	NNS
cord-304876-txaoz7oh	540	7	of	of	IN
cord-304876-txaoz7oh	540	8	T-705	t-705	NN
cord-304876-txaoz7oh	540	9	against	against	IN
cord-304876-txaoz7oh	540	10	arenavirus	arenavirus	NNP
cord-304876-txaoz7oh	540	11	and	and	CC
cord-304876-txaoz7oh	540	12	bunyavirus	bunyavirus	NNP
cord-304876-txaoz7oh	540	13	infections	infection	NNS
cord-304876-txaoz7oh	540	14	Efficacy	Efficacy	NNP
cord-304876-txaoz7oh	540	15	of	of	IN
cord-304876-txaoz7oh	540	16	favipiravir	favipiravir	NNS
cord-304876-txaoz7oh	540	17	(	(	-LRB-
cord-304876-txaoz7oh	540	18	T-705	t-705	NN
cord-304876-txaoz7oh	540	19	)	)	-RRB-
cord-304876-txaoz7oh	540	20	and	and	CC
cord-304876-txaoz7oh	540	21	T-1106	t-1106	CD
cord-304876-txaoz7oh	540	22	pyrazine	pyrazine	JJ
cord-304876-txaoz7oh	540	23	derivatives	derivative	NNS
cord-304876-txaoz7oh	540	24	in	in	IN
cord-304876-txaoz7oh	540	25	phlebovirus	phlebovirus	NNP
cord-304876-txaoz7oh	540	26	disease	disease	NN
cord-304876-txaoz7oh	540	27	models	model	NNS
cord-304876-txaoz7oh	540	28	Activity	Activity	NNP
cord-304876-txaoz7oh	540	29	of	of	IN
cord-304876-txaoz7oh	540	30	T-705	t-705	NN
cord-304876-txaoz7oh	540	31	in	in	IN
cord-304876-txaoz7oh	540	32	a	a	DT
cord-304876-txaoz7oh	540	33	hamster	hamster	NN
cord-304876-txaoz7oh	540	34	model	model	NN
cord-304876-txaoz7oh	540	35	of	of	IN
cord-304876-txaoz7oh	540	36	yellow	yellow	JJ
cord-304876-txaoz7oh	540	37	fever	fever	NN
cord-304876-txaoz7oh	540	38	virus	virus	NN
cord-304876-txaoz7oh	540	39	infection	infection	NN
cord-304876-txaoz7oh	540	40	in	in	IN
cord-304876-txaoz7oh	540	41	comparison	comparison	NN
cord-304876-txaoz7oh	540	42	with	with	IN
cord-304876-txaoz7oh	540	43	that	that	DT
cord-304876-txaoz7oh	540	44	of	of	IN
cord-304876-txaoz7oh	540	45	a	a	DT
cord-304876-txaoz7oh	540	46	chemically	chemically	RB
cord-304876-txaoz7oh	540	47	related	relate	VBN
cord-304876-txaoz7oh	540	48	compound	compound	NN
cord-304876-txaoz7oh	540	49	,	,	,
cord-304876-txaoz7oh	541	1	T-1106	T-1106	NNP
cord-304876-txaoz7oh	541	2	Effect	effect	NN
cord-304876-txaoz7oh	541	3	of	of	IN
cord-304876-txaoz7oh	541	4	T-705	t-705	NN
cord-304876-txaoz7oh	541	5	treatment	treatment	NN
cord-304876-txaoz7oh	541	6	on	on	IN
cord-304876-txaoz7oh	541	7	western	western	JJ
cord-304876-txaoz7oh	541	8	equine	equine	NN
cord-304876-txaoz7oh	541	9	encephalitis	encephalitis	RB
cord-304876-txaoz7oh	541	10	in	in	IN
cord-304876-txaoz7oh	541	11	a	a	DT
cord-304876-txaoz7oh	541	12	mouse	mouse	NN
cord-304876-txaoz7oh	541	13	model	model	NN
cord-304876-txaoz7oh	541	14	T-705	T-705	NNS
cord-304876-txaoz7oh	541	15	(	(	-LRB-
cord-304876-txaoz7oh	541	16	favipiravir	favipiravir	NNP
cord-304876-txaoz7oh	541	17	)	)	-RRB-
cord-304876-txaoz7oh	541	18	inhibition	inhibition	NN
cord-304876-txaoz7oh	541	19	of	of	IN
cord-304876-txaoz7oh	541	20	arenavirus	arenavirus	NNP
cord-304876-txaoz7oh	541	21	replication	replication	NN
cord-304876-txaoz7oh	541	22	in	in	IN
cord-304876-txaoz7oh	541	23	cell	cell	NN
cord-304876-txaoz7oh	541	24	culture	culture	NN
cord-304876-txaoz7oh	541	25	T-705	t-705	NN
cord-304876-txaoz7oh	541	26	)	)	-RRB-
cord-304876-txaoz7oh	541	27	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	541	28	in	in	IN
cord-304876-txaoz7oh	541	29	vitro	vitro	FW
cord-304876-txaoz7oh	541	30	norovirus	norovirus	NN
cord-304876-txaoz7oh	541	31	replication	replication	NN
cord-304876-txaoz7oh	541	32	Lethal	lethal	JJ
cord-304876-txaoz7oh	541	33	mutagenesis	mutagenesis	NN
cord-304876-txaoz7oh	541	34	of	of	IN
cord-304876-txaoz7oh	541	35	hepatitis	hepatitis	NN
cord-304876-txaoz7oh	541	36	C	C	NNP
cord-304876-txaoz7oh	541	37	virus	virus	NN
cord-304876-txaoz7oh	541	38	induced	induce	VBN
cord-304876-txaoz7oh	541	39	by	by	IN
cord-304876-txaoz7oh	541	40	favipiravir	favipiravir	NNP
cord-304876-txaoz7oh	541	41	Structure	Structure	NNP
cord-304876-txaoz7oh	541	42	-	-	HYPH
cord-304876-txaoz7oh	541	43	activity	activity	NN
cord-304876-txaoz7oh	541	44	relationship	relationship	NN
cord-304876-txaoz7oh	541	45	analysis	analysis	NN
cord-304876-txaoz7oh	541	46	of	of	IN
cord-304876-txaoz7oh	541	47	mitochondrial	mitochondrial	JJ
cord-304876-txaoz7oh	541	48	toxicity	toxicity	NN
cord-304876-txaoz7oh	541	49	caused	cause	VBN
cord-304876-txaoz7oh	541	50	by	by	IN
cord-304876-txaoz7oh	541	51	antiviral	antiviral	JJ
cord-304876-txaoz7oh	541	52	ribonucleoside	ribonucleoside	NN
cord-304876-txaoz7oh	541	53	analogs	analog	NNS
cord-304876-txaoz7oh	541	54	Biochemical	biochemical	JJ
cord-304876-txaoz7oh	541	55	evaluation	evaluation	NN
cord-304876-txaoz7oh	541	56	of	of	IN
cord-304876-txaoz7oh	541	57	the	the	DT
cord-304876-txaoz7oh	541	58	inhibition	inhibition	NN
cord-304876-txaoz7oh	541	59	properties	property	NNS
cord-304876-txaoz7oh	541	60	of	of	IN
cord-304876-txaoz7oh	541	61	favipiravir	favipiravir	NNS
cord-304876-txaoz7oh	541	62	and	and	CC
cord-304876-txaoz7oh	541	63	2'-C	2'-c	CD
cord-304876-txaoz7oh	541	64	-	-	HYPH
cord-304876-txaoz7oh	541	65	methylcytidine	methylcytidine	NN
cord-304876-txaoz7oh	541	66	triphosphates	triphosphate	NNS
cord-304876-txaoz7oh	541	67	against	against	IN
cord-304876-txaoz7oh	541	68	human	human	NN
cord-304876-txaoz7oh	541	69	and	and	CC
cord-304876-txaoz7oh	541	70	mouse	mouse	NN
cord-304876-txaoz7oh	541	71	norovirus	norovirus	NN
cord-304876-txaoz7oh	541	72	RNA	RNA	NNP
cord-304876-txaoz7oh	541	73	polymerases	polymerases	NNP
cord-304876-txaoz7oh	541	74	Synthesis	Synthesis	NNP
cord-304876-txaoz7oh	541	75	of	of	IN
cord-304876-txaoz7oh	541	76	T-705-ribonucleoside	T-705-ribonucleoside	NNP
cord-304876-txaoz7oh	541	77	and	and	CC
cord-304876-txaoz7oh	541	78	T-705-ribonucleotide	T-705-ribonucleotide	NNP
cord-304876-txaoz7oh	541	79	and	and	CC
cord-304876-txaoz7oh	541	80	studies	study	NNS
cord-304876-txaoz7oh	541	81	of	of	IN
cord-304876-txaoz7oh	541	82	chemical	chemical	NN
cord-304876-txaoz7oh	541	83	stability	stability	NN
cord-304876-txaoz7oh	542	1	Distinct	distinct	JJ
cord-304876-txaoz7oh	542	2	effects	effect	NNS
cord-304876-txaoz7oh	542	3	of	of	IN
cord-304876-txaoz7oh	542	4	T-705	t-705	NN
cord-304876-txaoz7oh	542	5	(	(	-LRB-
cord-304876-txaoz7oh	542	6	favipiravir	favipiravir	NNP
cord-304876-txaoz7oh	542	7	)	)	-RRB-
cord-304876-txaoz7oh	542	8	and	and	CC
cord-304876-txaoz7oh	542	9	ribavirin	ribavirin	RB
cord-304876-txaoz7oh	542	10	on	on	IN
cord-304876-txaoz7oh	542	11	influenza	influenza	NN
cord-304876-txaoz7oh	542	12	virus	virus	NN
cord-304876-txaoz7oh	542	13	replication	replication	NN
cord-304876-txaoz7oh	542	14	and	and	CC
cord-304876-txaoz7oh	542	15	viral	viral	JJ
cord-304876-txaoz7oh	542	16	RNA	RNA	NNP
cord-304876-txaoz7oh	542	17	synthesis	synthesis	NN
cord-304876-txaoz7oh	542	18	Discovery	Discovery	NNP
cord-304876-txaoz7oh	542	19	of	of	IN
cord-304876-txaoz7oh	542	20	4'-chloromethyl-2'-deoxy-3',5'-di	4'-chloromethyl-2'-deoxy-3',5'-di	CD
cord-304876-txaoz7oh	542	21	-	-	HYPH
cord-304876-txaoz7oh	542	22	O	o	NN
cord-304876-txaoz7oh	542	23	-	-	HYPH
cord-304876-txaoz7oh	542	24	isobutyryl-2'-fluorocytidine	isobutyryl-2'-fluorocytidine	NN
cord-304876-txaoz7oh	542	25	(	(	-LRB-
cord-304876-txaoz7oh	542	26	ALS-8176	ALS-8176	NNP
cord-304876-txaoz7oh	542	27	)	)	-RRB-
cord-304876-txaoz7oh	542	28	,	,	,
cord-304876-txaoz7oh	542	29	a	a	DT
cord-304876-txaoz7oh	542	30	first	first	JJ
cord-304876-txaoz7oh	542	31	-	-	HYPH
cord-304876-txaoz7oh	542	32	in	in	IN
cord-304876-txaoz7oh	542	33	-	-	HYPH
cord-304876-txaoz7oh	542	34	class	class	NN
cord-304876-txaoz7oh	542	35	RSV	rsv	NN
cord-304876-txaoz7oh	542	36	polymerase	polymerase	NN
cord-304876-txaoz7oh	542	37	inhibitor	inhibitor	NN
cord-304876-txaoz7oh	542	38	for	for	IN
cord-304876-txaoz7oh	542	39	treatment	treatment	NN
cord-304876-txaoz7oh	542	40	of	of	IN
cord-304876-txaoz7oh	542	41	human	human	JJ
cord-304876-txaoz7oh	542	42	respiratory	respiratory	JJ
cord-304876-txaoz7oh	542	43	syncytial	syncytial	JJ
cord-304876-txaoz7oh	542	44	virus	virus	NN
cord-304876-txaoz7oh	542	45	infection	infection	NN
cord-304876-txaoz7oh	542	46	Molecular	molecular	JJ
cord-304876-txaoz7oh	542	47	basis	basis	NN
cord-304876-txaoz7oh	542	48	for	for	IN
cord-304876-txaoz7oh	542	49	the	the	DT
cord-304876-txaoz7oh	542	50	selective	selective	JJ
cord-304876-txaoz7oh	542	51	inhibition	inhibition	NN
cord-304876-txaoz7oh	542	52	of	of	IN
cord-304876-txaoz7oh	542	53	respiratory	respiratory	JJ
cord-304876-txaoz7oh	542	54	syncytial	syncytial	JJ
cord-304876-txaoz7oh	542	55	virus	virus	NN
cord-304876-txaoz7oh	542	56	RNA	rna	NN
cord-304876-txaoz7oh	542	57	polymerase	polymerase	NN
cord-304876-txaoz7oh	542	58	by	by	IN
cord-304876-txaoz7oh	542	59	2'-fluoro-4'-chloromethyl	2'-fluoro-4'-chloromethyl	CD
cord-304876-txaoz7oh	542	60	-	-	HYPH
cord-304876-txaoz7oh	542	61	cytidine	cytidine	NN
cord-304876-txaoz7oh	542	62	triphosphate	triphosphate	NN
cord-304876-txaoz7oh	542	63	Development	Development	NNP
cord-304876-txaoz7oh	542	64	of	of	IN
cord-304876-txaoz7oh	542	65	ALS-8112	ALS-8112	NNP
cord-304876-txaoz7oh	542	66	/	/	SYM
cord-304876-txaoz7oh	542	67	ALS-8176	ALS-8176	NNPS
cord-304876-txaoz7oh	542	68	as	as	IN
cord-304876-txaoz7oh	542	69	an	an	DT
cord-304876-txaoz7oh	542	70	effective	effective	JJ
cord-304876-txaoz7oh	542	71	replication	replication	NN
cord-304876-txaoz7oh	542	72	inhibitor	inhibitor	NN
cord-304876-txaoz7oh	542	73	of	of	IN
cord-304876-txaoz7oh	542	74	human	human	JJ
cord-304876-txaoz7oh	542	75	metapneumovirus	metapneumovirus	NNP
cord-304876-txaoz7oh	542	76	Activity	Activity	NNP
cord-304876-txaoz7oh	542	77	of	of	IN
cord-304876-txaoz7oh	542	78	oral	oral	JJ
cord-304876-txaoz7oh	542	79	ALS-008176	als-008176	NN
cord-304876-txaoz7oh	542	80	in	in	IN
cord-304876-txaoz7oh	542	81	a	a	DT
cord-304876-txaoz7oh	542	82	respiratory	respiratory	JJ
cord-304876-txaoz7oh	542	83	syncytial	syncytial	JJ
cord-304876-txaoz7oh	542	84	virus	virus	NN
cord-304876-txaoz7oh	542	85	challenge	challenge	NN
cord-304876-txaoz7oh	542	86	study	study	NN
cord-304876-txaoz7oh	542	87	Therapeutic	therapeutic	JJ
cord-304876-txaoz7oh	542	88	efficacy	efficacy	NN
cord-304876-txaoz7oh	542	89	of	of	IN
cord-304876-txaoz7oh	542	90	the	the	DT
cord-304876-txaoz7oh	542	91	small	small	JJ
cord-304876-txaoz7oh	542	92	molecule	molecule	NN
cord-304876-txaoz7oh	542	93	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	542	94	against	against	IN
cord-304876-txaoz7oh	542	95	Ebola	Ebola	NNP
cord-304876-txaoz7oh	542	96	virus	virus	NN
cord-304876-txaoz7oh	542	97	in	in	IN
cord-304876-txaoz7oh	542	98	rhesus	rhesu	NNS
cord-304876-txaoz7oh	542	99	monkeys	monkey	NNS
cord-304876-txaoz7oh	542	100	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	542	101	and	and	CC
cord-304876-txaoz7oh	542	102	its	-PRON-	PRP$
cord-304876-txaoz7oh	542	103	parent	parent	NN
cord-304876-txaoz7oh	542	104	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	542	105	analog	analog	NN
cord-304876-txaoz7oh	542	106	inhibit	inhibit	VBP
cord-304876-txaoz7oh	542	107	filo-	filo-	RB
cord-304876-txaoz7oh	542	108	,	,	,
cord-304876-txaoz7oh	542	109	pneumo-	pneumo-	NN
cord-304876-txaoz7oh	542	110	,	,	,
cord-304876-txaoz7oh	542	111	and	and	CC
cord-304876-txaoz7oh	542	112	paramyxoviruses	paramyxoviruses	NNP
cord-304876-txaoz7oh	542	113	Discovery	Discovery	NNP
cord-304876-txaoz7oh	542	114	and	and	CC
cord-304876-txaoz7oh	542	115	synthesis	synthesis	NN
cord-304876-txaoz7oh	542	116	of	of	IN
cord-304876-txaoz7oh	542	117	a	a	DT
cord-304876-txaoz7oh	542	118	phosphoramidate	phosphoramidate	JJ
cord-304876-txaoz7oh	542	119	prodrug	prodrug	NN
cord-304876-txaoz7oh	542	120	of	of	IN
cord-304876-txaoz7oh	542	121	a	a	DT
cord-304876-txaoz7oh	542	122	pyrrolo	pyrrolo	NN
cord-304876-txaoz7oh	542	123	[	[	-LRB-
cord-304876-txaoz7oh	542	124	2,1-f][triazin-4-amino	2,1-f][triazin-4-amino	CD
cord-304876-txaoz7oh	542	125	]	]	-RRB-
cord-304876-txaoz7oh	542	126	adenine	adenine	NN
cord-304876-txaoz7oh	542	127	C	c	NN
cord-304876-txaoz7oh	542	128	-	-	HYPH
cord-304876-txaoz7oh	542	129	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	542	130	(	(	-LRB-
cord-304876-txaoz7oh	542	131	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	542	132	)	)	-RRB-
cord-304876-txaoz7oh	542	133	for	for	IN
cord-304876-txaoz7oh	542	134	the	the	DT
cord-304876-txaoz7oh	542	135	treatment	treatment	NN
cord-304876-txaoz7oh	542	136	of	of	IN
cord-304876-txaoz7oh	542	137	Ebola	Ebola	NNP
cord-304876-txaoz7oh	542	138	and	and	CC
cord-304876-txaoz7oh	542	139	emerging	emerge	VBG
cord-304876-txaoz7oh	542	140	viruses	virus	NNS
cord-304876-txaoz7oh	543	1	Inhibition	inhibition	NN
cord-304876-txaoz7oh	543	2	of	of	IN
cord-304876-txaoz7oh	543	3	hepatitis	hepatitis	NN
cord-304876-txaoz7oh	543	4	C	c	NN
cord-304876-txaoz7oh	543	5	virus	virus	NN
cord-304876-txaoz7oh	543	6	replication	replication	NN
cord-304876-txaoz7oh	543	7	by	by	IN
cord-304876-txaoz7oh	543	8	GS-6620	GS-6620	NNP
cord-304876-txaoz7oh	543	9	,	,	,
cord-304876-txaoz7oh	543	10	a	a	DT
cord-304876-txaoz7oh	543	11	potent	potent	JJ
cord-304876-txaoz7oh	543	12	C	c	NN
cord-304876-txaoz7oh	543	13	-	-	HYPH
cord-304876-txaoz7oh	543	14	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	543	15	monophosphate	monophosphate	NN
cord-304876-txaoz7oh	543	16	prodrug	prodrug	NN
cord-304876-txaoz7oh	543	17	Discovery	Discovery	NNP
cord-304876-txaoz7oh	543	18	of	of	IN
cord-304876-txaoz7oh	543	19	the	the	DT
cord-304876-txaoz7oh	543	20	first	first	JJ
cord-304876-txaoz7oh	543	21	C	c	NN
cord-304876-txaoz7oh	543	22	-	-	HYPH
cord-304876-txaoz7oh	543	23	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	543	24	HCV	HCV	NNP
cord-304876-txaoz7oh	543	25	polymerase	polymerase	NN
cord-304876-txaoz7oh	543	26	inhibitor	inhibitor	NN
cord-304876-txaoz7oh	543	27	(	(	-LRB-
cord-304876-txaoz7oh	543	28	GS-6620	GS-6620	NNP
cord-304876-txaoz7oh	543	29	)	)	-RRB-
cord-304876-txaoz7oh	543	30	with	with	IN
cord-304876-txaoz7oh	543	31	demonstrated	demonstrate	VBN
cord-304876-txaoz7oh	543	32	antiviral	antiviral	JJ
cord-304876-txaoz7oh	543	33	response	response	NN
cord-304876-txaoz7oh	543	34	in	in	IN
cord-304876-txaoz7oh	543	35	HCV	HCV	NNP
cord-304876-txaoz7oh	543	36	infected	infect	VBN
cord-304876-txaoz7oh	543	37	patients	patient	NNS
cord-304876-txaoz7oh	544	1	Late	late	JJ
cord-304876-txaoz7oh	544	2	Ebola	Ebola	NNP
cord-304876-txaoz7oh	544	3	virus	virus	NN
cord-304876-txaoz7oh	544	4	relapse	relapse	NN
cord-304876-txaoz7oh	544	5	causing	cause	VBG
cord-304876-txaoz7oh	544	6	meningoencephalitis	meningoencephalitis	NNP
cord-304876-txaoz7oh	544	7	:	:	:
cord-304876-txaoz7oh	544	8	a	a	DT
cord-304876-txaoz7oh	544	9	case	case	NN
cord-304876-txaoz7oh	544	10	report	report	NN
cord-304876-txaoz7oh	544	11	First	first	JJ
cord-304876-txaoz7oh	544	12	newborn	newborn	JJ
cord-304876-txaoz7oh	544	13	baby	baby	NN
cord-304876-txaoz7oh	544	14	to	to	TO
cord-304876-txaoz7oh	544	15	receive	receive	VB
cord-304876-txaoz7oh	544	16	experimental	experimental	JJ
cord-304876-txaoz7oh	544	17	therapies	therapy	NNS
cord-304876-txaoz7oh	544	18	survives	survive	VBZ
cord-304876-txaoz7oh	544	19	Ebola	Ebola	NNP
cord-304876-txaoz7oh	544	20	virus	virus	NN
cord-304876-txaoz7oh	544	21	disease	disease	NN
cord-304876-txaoz7oh	544	22	Broad	Broad	NNP
cord-304876-txaoz7oh	544	23	-	-	HYPH
cord-304876-txaoz7oh	544	24	spectrum	spectrum	NN
cord-304876-txaoz7oh	544	25	antiviral	antiviral	JJ
cord-304876-txaoz7oh	544	26	GS-5734	GS-5734	NNS
cord-304876-txaoz7oh	544	27	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	544	28	both	both	DT
cord-304876-txaoz7oh	544	29	epidemic	epidemic	NN
cord-304876-txaoz7oh	544	30	and	and	CC
cord-304876-txaoz7oh	544	31	zoonotic	zoonotic	JJ
cord-304876-txaoz7oh	544	32	coronaviruses	coronaviruse	NNS
cord-304876-txaoz7oh	545	1	The	the	DT
cord-304876-txaoz7oh	545	2	nucleoside	nucleoside	NN
cord-304876-txaoz7oh	545	3	prodrug	prodrug	NN
cord-304876-txaoz7oh	545	4	GS-5734	GS-5734	NNP
cord-304876-txaoz7oh	545	5	inhibits	inhibit	VBZ
cord-304876-txaoz7oh	545	6	multiple	multiple	JJ
cord-304876-txaoz7oh	545	7	coronaviruses	coronaviruse	NNS
cord-304876-txaoz7oh	545	8	and	and	CC
cord-304876-txaoz7oh	545	9	selects	select	VBZ
cord-304876-txaoz7oh	545	10	for	for	IN
cord-304876-txaoz7oh	545	11	resistance	resistance	NN
cord-304876-txaoz7oh	545	12	mutations	mutation	NNS
cord-304876-txaoz7oh	545	13	in	in	IN
cord-304876-txaoz7oh	545	14	the	the	DT
cord-304876-txaoz7oh	545	15	RNA	RNA	NNP
cord-304876-txaoz7oh	545	16	-	-	HYPH
cord-304876-txaoz7oh	545	17	dependent	dependent	JJ
cord-304876-txaoz7oh	545	18	RNA	RNA	NNP
cord-304876-txaoz7oh	545	19	polymerase	polymerase	NN
cord-304876-txaoz7oh	545	20	that	that	WDT
cord-304876-txaoz7oh	545	21	are	be	VBP
cord-304876-txaoz7oh	545	22	associated	associate	VBN
cord-304876-txaoz7oh	545	23	with	with	IN
cord-304876-txaoz7oh	545	24	a	a	DT
cord-304876-txaoz7oh	545	25	decrease	decrease	NN
cord-304876-txaoz7oh	545	26	in	in	IN
cord-304876-txaoz7oh	545	27	viral	viral	JJ
cord-304876-txaoz7oh	545	28	replication	replication	NN
cord-304876-txaoz7oh	545	29	fitness	fitness	NN
cord-304876-txaoz7oh	545	30	We	-PRON-	PRP
cord-304876-txaoz7oh	545	31	wish	wish	VBP
cord-304876-txaoz7oh	545	32	to	to	TO
cord-304876-txaoz7oh	545	33	thank	thank	VB
cord-304876-txaoz7oh	545	34	Leo	Leo	NNP
cord-304876-txaoz7oh	545	35	Beigelman	Beigelman	NNP
cord-304876-txaoz7oh	545	36	,	,	,
cord-304876-txaoz7oh	545	37	Julian	Julian	NNP
cord-304876-txaoz7oh	545	38	Symons	Symons	NNP
cord-304876-txaoz7oh	545	39	,	,	,
cord-304876-txaoz7oh	545	40	Andreas	Andreas	NNP
cord-304876-txaoz7oh	545	41	Jekle	Jekle	NNP
cord-304876-txaoz7oh	545	42	,	,	,
cord-304876-txaoz7oh	545	43	and	and	CC
cord-304876-txaoz7oh	545	44	Peggy	Peggy	NNP
cord-304876-txaoz7oh	545	45	Korn	Korn	NNP
cord-304876-txaoz7oh	545	46	for	for	IN
cord-304876-txaoz7oh	545	47	their	-PRON-	PRP$
cord-304876-txaoz7oh	545	48	review	review	NN
cord-304876-txaoz7oh	545	49	of	of	IN
cord-304876-txaoz7oh	545	50	the	the	DT
cord-304876-txaoz7oh	545	51	manuscript	manuscript	NN
cord-304876-txaoz7oh	545	52	.	.	.
cord-304876-txaoz7oh	546	1	The	the	DT
cord-304876-txaoz7oh	546	2	author(s	author(s	NNP
cord-304876-txaoz7oh	546	3	)	)	-RRB-
cord-304876-txaoz7oh	546	4	declared	declare	VBD
cord-304876-txaoz7oh	546	5	no	no	DT
cord-304876-txaoz7oh	546	6	potential	potential	JJ
cord-304876-txaoz7oh	546	7	conflicts	conflict	NNS
cord-304876-txaoz7oh	546	8	of	of	IN
cord-304876-txaoz7oh	546	9	interest	interest	NN
cord-304876-txaoz7oh	546	10	with	with	IN
cord-304876-txaoz7oh	546	11	respect	respect	NN
cord-304876-txaoz7oh	546	12	to	to	IN
cord-304876-txaoz7oh	546	13	the	the	DT
cord-304876-txaoz7oh	546	14	research	research	NN
cord-304876-txaoz7oh	546	15	,	,	,
cord-304876-txaoz7oh	546	16	authorship	authorship	NN
cord-304876-txaoz7oh	546	17	,	,	,
cord-304876-txaoz7oh	546	18	and/or	and/or	CC
cord-304876-txaoz7oh	546	19	publication	publication	NN
cord-304876-txaoz7oh	546	20	of	of	IN
cord-304876-txaoz7oh	546	21	this	this	DT
cord-304876-txaoz7oh	546	22	article	article	NN
cord-304876-txaoz7oh	546	23	.	.	.
cord-304876-txaoz7oh	547	1	Janssen	Janssen	NNP
cord-304876-txaoz7oh	547	2	Research	Research	NNP
cord-304876-txaoz7oh	547	3	&	&	CC
cord-304876-txaoz7oh	547	4	Development	Development	NNP
cord-304876-txaoz7oh	547	5	provided	provide	VBD
cord-304876-txaoz7oh	547	6	support	support	NN
cord-304876-txaoz7oh	547	7	in	in	IN
cord-304876-txaoz7oh	547	8	the	the	DT
cord-304876-txaoz7oh	547	9	form	form	NN
cord-304876-txaoz7oh	547	10	of	of	IN
cord-304876-txaoz7oh	547	11	salaries	salary	NNS
cord-304876-txaoz7oh	547	12	for	for	IN
cord-304876-txaoz7oh	547	13	all	all	DT
cord-304876-txaoz7oh	547	14	authors	author	NNS
cord-304876-txaoz7oh	547	15	but	but	CC
cord-304876-txaoz7oh	547	16	did	do	VBD
cord-304876-txaoz7oh	547	17	not	not	RB
cord-304876-txaoz7oh	547	18	have	have	VB
cord-304876-txaoz7oh	547	19	any	any	DT
cord-304876-txaoz7oh	547	20	additional	additional	JJ
cord-304876-txaoz7oh	547	21	role	role	NN
cord-304876-txaoz7oh	547	22	in	in	IN
cord-304876-txaoz7oh	547	23	the	the	DT
cord-304876-txaoz7oh	547	24	study	study	NN
cord-304876-txaoz7oh	547	25	design	design	NN
cord-304876-txaoz7oh	547	26	,	,	,
cord-304876-txaoz7oh	547	27	data	datum	NNS
cord-304876-txaoz7oh	547	28	collection	collection	NN
cord-304876-txaoz7oh	547	29	and	and	CC
cord-304876-txaoz7oh	547	30	analysis	analysis	NN
cord-304876-txaoz7oh	547	31	,	,	,
cord-304876-txaoz7oh	547	32	decision	decision	NN
cord-304876-txaoz7oh	547	33	to	to	TO
cord-304876-txaoz7oh	547	34	publish	publish	VB
cord-304876-txaoz7oh	547	35	,	,	,
cord-304876-txaoz7oh	547	36	or	or	CC
cord-304876-txaoz7oh	547	37	preparation	preparation	NN
cord-304876-txaoz7oh	547	38	of	of	IN
cord-304876-txaoz7oh	547	39	the	the	DT
cord-304876-txaoz7oh	547	40	manuscript	manuscript	NN
cord-304876-txaoz7oh	547	41	.	.	.