id	sid	tid	token	lemma	pos
cord-312001-8p7scli8	1	1	key	key	JJ
cord-312001-8p7scli8	2	1	:	:	:
cord-312001-8p7scli8	2	2	cord-312001	cord-312001	NNP
cord-312001-8p7scli8	2	3	-	-	HYPH
cord-312001-8p7scli8	2	4	8p7scli8	8p7scli8	CD
cord-312001-8p7scli8	2	5	authors	author	NNS
cord-312001-8p7scli8	2	6	:	:	:
cord-312001-8p7scli8	2	7	Majzoub	Majzoub	NNP
cord-312001-8p7scli8	2	8	,	,	,
cord-312001-8p7scli8	2	9	Karim	Karim	NNP
cord-312001-8p7scli8	2	10	;	;	:
cord-312001-8p7scli8	2	11	Wrensch	Wrensch	NNP
cord-312001-8p7scli8	2	12	,	,	,
cord-312001-8p7scli8	2	13	Florian	Florian	NNP
cord-312001-8p7scli8	2	14	;	;	:
cord-312001-8p7scli8	2	15	Baumert	Baumert	NNP
cord-312001-8p7scli8	2	16	,	,	,
cord-312001-8p7scli8	2	17	Thomas	Thomas	NNP
cord-312001-8p7scli8	2	18	F.	F.	NNP
cord-312001-8p7scli8	2	19	title	title	NN
cord-312001-8p7scli8	2	20	:	:	:
cord-312001-8p7scli8	3	1	The	the	DT
cord-312001-8p7scli8	3	2	Innate	Innate	NNP
cord-312001-8p7scli8	3	3	Antiviral	Antiviral	NNP
cord-312001-8p7scli8	3	4	Response	Response	NNP
cord-312001-8p7scli8	3	5	in	in	IN
cord-312001-8p7scli8	3	6	Animals	animal	NNS
cord-312001-8p7scli8	3	7	:	:	:
cord-312001-8p7scli8	4	1	An	an	DT
cord-312001-8p7scli8	4	2	Evolutionary	Evolutionary	NNP
cord-312001-8p7scli8	4	3	Perspective	perspective	NN
cord-312001-8p7scli8	4	4	from	from	IN
cord-312001-8p7scli8	4	5	Flagellates	Flagellates	NNPS
cord-312001-8p7scli8	4	6	to	to	IN
cord-312001-8p7scli8	4	7	Humans	human	NNS
cord-312001-8p7scli8	4	8	date	date	NN
cord-312001-8p7scli8	4	9	:	:	:
cord-312001-8p7scli8	4	10	2019	2019	CD
cord-312001-8p7scli8	4	11	-	-	HYPH
cord-312001-8p7scli8	4	12	08	08	CD
cord-312001-8p7scli8	4	13	-	-	SYM
cord-312001-8p7scli8	4	14	16	16	CD
cord-312001-8p7scli8	4	15	journal	journal	NN
cord-312001-8p7scli8	4	16	:	:	:
cord-312001-8p7scli8	5	1	Viruses	virus	NNS
cord-312001-8p7scli8	5	2	DOI	DOI	NNP
cord-312001-8p7scli8	5	3	:	:	:
cord-312001-8p7scli8	6	1	10.3390	10.3390	CD
cord-312001-8p7scli8	6	2	/	/	SYM
cord-312001-8p7scli8	6	3	v11080758	v11080758	NNP
cord-312001-8p7scli8	6	4	sha	sha	NNP
cord-312001-8p7scli8	6	5	:	:	:
cord-312001-8p7scli8	7	1	54458ee775b72a18830ed116a31336638b909fa7	54458ee775b72a18830ed116a31336638b909fa7	CD
cord-312001-8p7scli8	7	2	doc_id	doc_id	CD
cord-312001-8p7scli8	7	3	:	:	:
cord-312001-8p7scli8	7	4	312001	312001	CD
cord-312001-8p7scli8	7	5	cord_uid	cord_uid	FW
cord-312001-8p7scli8	7	6	:	:	:
cord-312001-8p7scli8	8	1	8p7scli8	8p7scli8	CD
cord-312001-8p7scli8	8	2	Animal	animal	NN
cord-312001-8p7scli8	8	3	cells	cell	NNS
cord-312001-8p7scli8	8	4	have	have	VBP
cord-312001-8p7scli8	8	5	evolved	evolve	VBN
cord-312001-8p7scli8	8	6	dedicated	dedicated	JJ
cord-312001-8p7scli8	8	7	molecular	molecular	JJ
cord-312001-8p7scli8	8	8	systems	system	NNS
cord-312001-8p7scli8	8	9	for	for	IN
cord-312001-8p7scli8	8	10	sensing	sensing	NN
cord-312001-8p7scli8	8	11	and	and	CC
cord-312001-8p7scli8	8	12	delivering	deliver	VBG
cord-312001-8p7scli8	8	13	a	a	DT
cord-312001-8p7scli8	8	14	coordinated	coordinated	JJ
cord-312001-8p7scli8	8	15	response	response	NN
cord-312001-8p7scli8	8	16	to	to	IN
cord-312001-8p7scli8	8	17	viral	viral	JJ
cord-312001-8p7scli8	8	18	threats	threat	NNS
cord-312001-8p7scli8	8	19	.	.	.
cord-312001-8p7scli8	9	1	Our	-PRON-	PRP$
cord-312001-8p7scli8	9	2	understanding	understanding	NN
cord-312001-8p7scli8	9	3	of	of	IN
cord-312001-8p7scli8	9	4	these	these	DT
cord-312001-8p7scli8	9	5	pathways	pathway	NNS
cord-312001-8p7scli8	9	6	is	be	VBZ
cord-312001-8p7scli8	9	7	almost	almost	RB
cord-312001-8p7scli8	9	8	entirely	entirely	RB
cord-312001-8p7scli8	9	9	defined	define	VBN
cord-312001-8p7scli8	9	10	by	by	IN
cord-312001-8p7scli8	9	11	studies	study	NNS
cord-312001-8p7scli8	9	12	in	in	IN
cord-312001-8p7scli8	9	13	humans	human	NNS
cord-312001-8p7scli8	9	14	or	or	CC
cord-312001-8p7scli8	9	15	model	model	NN
cord-312001-8p7scli8	9	16	organisms	organism	NNS
cord-312001-8p7scli8	9	17	like	like	IN
cord-312001-8p7scli8	9	18	mice	mouse	NNS
cord-312001-8p7scli8	9	19	,	,	,
cord-312001-8p7scli8	9	20	fruit	fruit	NN
cord-312001-8p7scli8	9	21	flies	fly	NNS
cord-312001-8p7scli8	9	22	and	and	CC
cord-312001-8p7scli8	9	23	worms	worm	NNS
cord-312001-8p7scli8	9	24	.	.	.
cord-312001-8p7scli8	10	1	However	however	RB
cord-312001-8p7scli8	10	2	,	,	,
cord-312001-8p7scli8	10	3	new	new	JJ
cord-312001-8p7scli8	10	4	genomic	genomic	JJ
cord-312001-8p7scli8	10	5	and	and	CC
cord-312001-8p7scli8	10	6	functional	functional	JJ
cord-312001-8p7scli8	10	7	data	datum	NNS
cord-312001-8p7scli8	10	8	from	from	IN
cord-312001-8p7scli8	10	9	organisms	organism	NNS
cord-312001-8p7scli8	10	10	such	such	JJ
cord-312001-8p7scli8	10	11	as	as	IN
cord-312001-8p7scli8	10	12	sponges	sponge	NNS
cord-312001-8p7scli8	10	13	,	,	,
cord-312001-8p7scli8	10	14	anemones	anemone	NNS
cord-312001-8p7scli8	10	15	and	and	CC
cord-312001-8p7scli8	10	16	mollusks	mollusk	NNS
cord-312001-8p7scli8	10	17	are	be	VBP
cord-312001-8p7scli8	10	18	helping	help	VBG
cord-312001-8p7scli8	10	19	redefine	redefine	VB
cord-312001-8p7scli8	10	20	our	-PRON-	PRP$
cord-312001-8p7scli8	10	21	understanding	understanding	NN
cord-312001-8p7scli8	10	22	of	of	IN
cord-312001-8p7scli8	10	23	these	these	DT
cord-312001-8p7scli8	10	24	immune	immune	JJ
cord-312001-8p7scli8	10	25	systems	system	NNS
cord-312001-8p7scli8	10	26	and	and	CC
cord-312001-8p7scli8	10	27	their	-PRON-	PRP$
cord-312001-8p7scli8	10	28	evolution	evolution	NN
cord-312001-8p7scli8	10	29	.	.	.
cord-312001-8p7scli8	11	1	In	in	IN
cord-312001-8p7scli8	11	2	this	this	DT
cord-312001-8p7scli8	11	3	review	review	NN
cord-312001-8p7scli8	11	4	,	,	,
cord-312001-8p7scli8	11	5	we	-PRON-	PRP
cord-312001-8p7scli8	11	6	will	will	MD
cord-312001-8p7scli8	11	7	discuss	discuss	VB
cord-312001-8p7scli8	11	8	our	-PRON-	PRP$
cord-312001-8p7scli8	11	9	current	current	JJ
cord-312001-8p7scli8	11	10	knowledge	knowledge	NN
cord-312001-8p7scli8	11	11	of	of	IN
cord-312001-8p7scli8	11	12	the	the	DT
cord-312001-8p7scli8	11	13	innate	innate	JJ
cord-312001-8p7scli8	11	14	immune	immune	JJ
cord-312001-8p7scli8	11	15	pathways	pathway	NNS
cord-312001-8p7scli8	11	16	involved	involve	VBN
cord-312001-8p7scli8	11	17	in	in	IN
cord-312001-8p7scli8	11	18	sensing	sensing	NN
cord-312001-8p7scli8	11	19	,	,	,
cord-312001-8p7scli8	11	20	signaling	signal	VBG
cord-312001-8p7scli8	11	21	and	and	CC
cord-312001-8p7scli8	11	22	inducing	induce	VBG
cord-312001-8p7scli8	11	23	genes	gene	NNS
cord-312001-8p7scli8	11	24	to	to	TO
cord-312001-8p7scli8	11	25	counter	counter	VB
cord-312001-8p7scli8	11	26	viral	viral	JJ
cord-312001-8p7scli8	11	27	infections	infection	NNS
cord-312001-8p7scli8	11	28	in	in	IN
cord-312001-8p7scli8	11	29	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	11	30	animals	animal	NNS
cord-312001-8p7scli8	11	31	.	.	.
cord-312001-8p7scli8	12	1	We	-PRON-	PRP
cord-312001-8p7scli8	12	2	will	will	MD
cord-312001-8p7scli8	12	3	then	then	RB
cord-312001-8p7scli8	12	4	focus	focus	VB
cord-312001-8p7scli8	12	5	on	on	IN
cord-312001-8p7scli8	12	6	some	some	DT
cord-312001-8p7scli8	12	7	central	central	JJ
cord-312001-8p7scli8	12	8	conserved	conserved	JJ
cord-312001-8p7scli8	12	9	players	player	NNS
cord-312001-8p7scli8	12	10	of	of	IN
cord-312001-8p7scli8	12	11	this	this	DT
cord-312001-8p7scli8	12	12	response	response	NN
cord-312001-8p7scli8	12	13	including	include	VBG
cord-312001-8p7scli8	12	14	Toll	toll	NN
cord-312001-8p7scli8	12	15	-	-	HYPH
cord-312001-8p7scli8	12	16	like	like	JJ
cord-312001-8p7scli8	12	17	receptors	receptor	NNS
cord-312001-8p7scli8	12	18	(	(	-LRB-
cord-312001-8p7scli8	12	19	TLRs	TLRs	NNP
cord-312001-8p7scli8	12	20	)	)	-RRB-
cord-312001-8p7scli8	12	21	,	,	,
cord-312001-8p7scli8	12	22	RIG	rig	NN
cord-312001-8p7scli8	12	23	-	-	HYPH
cord-312001-8p7scli8	12	24	I	-PRON-	PRP
cord-312001-8p7scli8	12	25	-	-	HYPH
cord-312001-8p7scli8	12	26	like	like	JJ
cord-312001-8p7scli8	12	27	receptors	receptor	NNS
cord-312001-8p7scli8	12	28	(	(	-LRB-
cord-312001-8p7scli8	12	29	RLRs	rlr	NNS
cord-312001-8p7scli8	12	30	)	)	-RRB-
cord-312001-8p7scli8	12	31	and	and	CC
cord-312001-8p7scli8	12	32	cGAS	cgas	NN
cord-312001-8p7scli8	12	33	-	-	HYPH
cord-312001-8p7scli8	12	34	STING	sting	NN
cord-312001-8p7scli8	12	35	,	,	,
cord-312001-8p7scli8	12	36	attempting	attempt	VBG
cord-312001-8p7scli8	12	37	to	to	TO
cord-312001-8p7scli8	12	38	put	put	VB
cord-312001-8p7scli8	12	39	their	-PRON-	PRP$
cord-312001-8p7scli8	12	40	evolution	evolution	NN
cord-312001-8p7scli8	12	41	into	into	IN
cord-312001-8p7scli8	12	42	perspective	perspective	NN
cord-312001-8p7scli8	12	43	.	.	.
cord-312001-8p7scli8	13	1	To	to	TO
cord-312001-8p7scli8	13	2	conclude	conclude	VB
cord-312001-8p7scli8	13	3	,	,	,
cord-312001-8p7scli8	13	4	we	-PRON-	PRP
cord-312001-8p7scli8	13	5	will	will	MD
cord-312001-8p7scli8	13	6	reflect	reflect	VB
cord-312001-8p7scli8	13	7	on	on	IN
cord-312001-8p7scli8	13	8	the	the	DT
cord-312001-8p7scli8	13	9	arms	arm	NNS
cord-312001-8p7scli8	13	10	race	race	NN
cord-312001-8p7scli8	13	11	that	that	WDT
cord-312001-8p7scli8	13	12	exists	exist	VBZ
cord-312001-8p7scli8	13	13	between	between	IN
cord-312001-8p7scli8	13	14	viruses	virus	NNS
cord-312001-8p7scli8	13	15	and	and	CC
cord-312001-8p7scli8	13	16	their	-PRON-	PRP$
cord-312001-8p7scli8	13	17	animal	animal	NN
cord-312001-8p7scli8	13	18	hosts	host	NNS
cord-312001-8p7scli8	13	19	,	,	,
cord-312001-8p7scli8	13	20	illustrated	illustrate	VBN
cord-312001-8p7scli8	13	21	by	by	IN
cord-312001-8p7scli8	13	22	the	the	DT
cord-312001-8p7scli8	13	23	dynamic	dynamic	JJ
cord-312001-8p7scli8	13	24	evolution	evolution	NN
cord-312001-8p7scli8	13	25	and	and	CC
cord-312001-8p7scli8	13	26	diversification	diversification	NN
cord-312001-8p7scli8	13	27	of	of	IN
cord-312001-8p7scli8	13	28	innate	innate	JJ
cord-312001-8p7scli8	13	29	immune	immune	JJ
cord-312001-8p7scli8	13	30	pathways	pathway	NNS
cord-312001-8p7scli8	13	31	.	.	.
cord-312001-8p7scli8	14	1	These	these	DT
cord-312001-8p7scli8	14	2	concepts	concept	NNS
cord-312001-8p7scli8	14	3	are	be	VBP
cord-312001-8p7scli8	14	4	not	not	RB
cord-312001-8p7scli8	14	5	only	only	RB
cord-312001-8p7scli8	14	6	important	important	JJ
cord-312001-8p7scli8	14	7	to	to	TO
cord-312001-8p7scli8	14	8	understand	understand	VB
cord-312001-8p7scli8	14	9	virus	virus	NN
cord-312001-8p7scli8	14	10	-	-	HYPH
cord-312001-8p7scli8	14	11	host	host	NN
cord-312001-8p7scli8	14	12	interactions	interaction	NNS
cord-312001-8p7scli8	14	13	in	in	IN
cord-312001-8p7scli8	14	14	general	general	JJ
cord-312001-8p7scli8	14	15	but	but	CC
cord-312001-8p7scli8	14	16	may	may	MD
cord-312001-8p7scli8	14	17	also	also	RB
cord-312001-8p7scli8	14	18	be	be	VB
cord-312001-8p7scli8	14	19	relevant	relevant	JJ
cord-312001-8p7scli8	14	20	for	for	IN
cord-312001-8p7scli8	14	21	the	the	DT
cord-312001-8p7scli8	14	22	development	development	NN
cord-312001-8p7scli8	14	23	of	of	IN
cord-312001-8p7scli8	14	24	novel	novel	JJ
cord-312001-8p7scli8	14	25	curative	curative	JJ
cord-312001-8p7scli8	14	26	approaches	approach	NNS
cord-312001-8p7scli8	14	27	against	against	IN
cord-312001-8p7scli8	14	28	human	human	JJ
cord-312001-8p7scli8	14	29	disease	disease	NN
cord-312001-8p7scli8	14	30	.	.	.
cord-312001-8p7scli8	15	1	The	the	DT
cord-312001-8p7scli8	15	2	animal	animal	NN
cord-312001-8p7scli8	15	3	kingdom	kingdom	NN
cord-312001-8p7scli8	15	4	,	,	,
cord-312001-8p7scli8	15	5	including	include	VBG
cord-312001-8p7scli8	15	6	humans	human	NNS
cord-312001-8p7scli8	15	7	,	,	,
cord-312001-8p7scli8	15	8	has	have	VBZ
cord-312001-8p7scli8	15	9	evolved	evolve	VBN
cord-312001-8p7scli8	15	10	while	while	IN
cord-312001-8p7scli8	15	11	facing	face	VBG
cord-312001-8p7scli8	15	12	constant	constant	JJ
cord-312001-8p7scli8	15	13	threats	threat	NNS
cord-312001-8p7scli8	15	14	from	from	IN
cord-312001-8p7scli8	15	15	viral	viral	JJ
cord-312001-8p7scli8	15	16	elements	element	NNS
cord-312001-8p7scli8	15	17	.	.	.
cord-312001-8p7scli8	16	1	Viruses	virus	NNS
cord-312001-8p7scli8	16	2	can	can	MD
cord-312001-8p7scli8	16	3	be	be	VB
cord-312001-8p7scli8	16	4	,	,	,
cord-312001-8p7scli8	16	5	in	in	IN
cord-312001-8p7scli8	16	6	some	some	DT
cord-312001-8p7scli8	16	7	cases	case	NNS
cord-312001-8p7scli8	16	8	,	,	,
cord-312001-8p7scli8	16	9	beneficial	beneficial	JJ
cord-312001-8p7scli8	16	10	for	for	IN
cord-312001-8p7scli8	16	11	a	a	DT
cord-312001-8p7scli8	16	12	given	give	VBN
cord-312001-8p7scli8	16	13	animal	animal	NN
cord-312001-8p7scli8	16	14	species	specie	NNS
cord-312001-8p7scli8	16	15	and	and	CC
cord-312001-8p7scli8	16	16	drive	drive	VB
cord-312001-8p7scli8	16	17	its	-PRON-	PRP$
cord-312001-8p7scli8	16	18	evolution	evolution	NN
cord-312001-8p7scli8	16	19	[	[	-LRB-
cord-312001-8p7scli8	16	20	1	1	CD
cord-312001-8p7scli8	16	21	]	]	-RRB-
cord-312001-8p7scli8	16	22	.	.	.
cord-312001-8p7scli8	17	1	However	however	RB
cord-312001-8p7scli8	17	2	,	,	,
cord-312001-8p7scli8	17	3	their	-PRON-	PRP$
cord-312001-8p7scli8	17	4	uncontrolled	uncontrolled	JJ
cord-312001-8p7scli8	17	5	replication	replication	NN
cord-312001-8p7scli8	17	6	may	may	MD
cord-312001-8p7scli8	17	7	cause	cause	VB
cord-312001-8p7scli8	17	8	disease	disease	NN
cord-312001-8p7scli8	17	9	and	and	CC
cord-312001-8p7scli8	17	10	prove	prove	VB
cord-312001-8p7scli8	17	11	fatal	fatal	JJ
cord-312001-8p7scli8	17	12	to	to	IN
cord-312001-8p7scli8	17	13	their	-PRON-	PRP$
cord-312001-8p7scli8	17	14	hosts	host	NNS
cord-312001-8p7scli8	17	15	.	.	.
cord-312001-8p7scli8	18	1	Consequently	consequently	RB
cord-312001-8p7scli8	18	2	,	,	,
cord-312001-8p7scli8	18	3	animal	animal	NN
cord-312001-8p7scli8	18	4	cells	cell	NNS
cord-312001-8p7scli8	18	5	have	have	VBP
cord-312001-8p7scli8	18	6	evolved	evolve	VBN
cord-312001-8p7scli8	18	7	devoted	devote	VBN
cord-312001-8p7scli8	18	8	pathways	pathway	NNS
cord-312001-8p7scli8	18	9	which	which	WDT
cord-312001-8p7scli8	18	10	(	(	-LRB-
cord-312001-8p7scli8	18	11	1	1	LS
cord-312001-8p7scli8	18	12	)	)	-RRB-
cord-312001-8p7scli8	18	13	sense	sense	NN
cord-312001-8p7scli8	18	14	and	and	CC
cord-312001-8p7scli8	18	15	recognize	recognize	VB
cord-312001-8p7scli8	18	16	pathogen	pathogen	NN
cord-312001-8p7scli8	18	17	-	-	HYPH
cord-312001-8p7scli8	18	18	associated	associate	VBN
cord-312001-8p7scli8	18	19	molecular	molecular	JJ
cord-312001-8p7scli8	18	20	patterns	pattern	NNS
cord-312001-8p7scli8	18	21	(	(	-LRB-
cord-312001-8p7scli8	18	22	PAMPs	PAMPs	NNP
cord-312001-8p7scli8	18	23	)	)	-RRB-
cord-312001-8p7scli8	18	24	and	and	CC
cord-312001-8p7scli8	18	25	,	,	,
cord-312001-8p7scli8	18	26	more	more	RBR
cord-312001-8p7scli8	18	27	particularly	particularly	RB
cord-312001-8p7scli8	18	28	,	,	,
cord-312001-8p7scli8	18	29	virus	virus	NN
cord-312001-8p7scli8	18	30	-	-	HYPH
cord-312001-8p7scli8	18	31	associated	associate	VBN
cord-312001-8p7scli8	18	32	molecular	molecular	JJ
cord-312001-8p7scli8	18	33	signatures	signature	NNS
cord-312001-8p7scli8	18	34	;	;	,
cord-312001-8p7scli8	18	35	(	(	-LRB-
cord-312001-8p7scli8	18	36	2	2	LS
cord-312001-8p7scli8	18	37	)	)	-RRB-
cord-312001-8p7scli8	18	38	initiate	initiate	VB
cord-312001-8p7scli8	18	39	signaling	signal	VBG
cord-312001-8p7scli8	18	40	cascades	cascade	NNS
cord-312001-8p7scli8	18	41	stemming	stem	VBG
cord-312001-8p7scli8	18	42	from	from	IN
cord-312001-8p7scli8	18	43	the	the	DT
cord-312001-8p7scli8	18	44	site	site	NN
cord-312001-8p7scli8	18	45	of	of	IN
cord-312001-8p7scli8	18	46	detection	detection	NN
cord-312001-8p7scli8	18	47	,	,	,
cord-312001-8p7scli8	18	48	translocating	translocate	VBG
cord-312001-8p7scli8	18	49	the	the	DT
cord-312001-8p7scli8	18	50	information	information	NN
cord-312001-8p7scli8	18	51	to	to	IN
cord-312001-8p7scli8	18	52	the	the	DT
cord-312001-8p7scli8	18	53	nucleus	nucleus	NN
cord-312001-8p7scli8	18	54	;	;	,
cord-312001-8p7scli8	18	55	and	and	CC
cord-312001-8p7scli8	18	56	(	(	-LRB-
cord-312001-8p7scli8	18	57	3	3	LS
cord-312001-8p7scli8	18	58	)	)	-RRB-
cord-312001-8p7scli8	18	59	induce	induce	VB
cord-312001-8p7scli8	18	60	a	a	DT
cord-312001-8p7scli8	18	61	transcriptional	transcriptional	JJ
cord-312001-8p7scli8	18	62	program	program	NN
cord-312001-8p7scli8	18	63	that	that	WDT
cord-312001-8p7scli8	18	64	confers	confer	VBZ
cord-312001-8p7scli8	18	65	an	an	DT
cord-312001-8p7scli8	18	66	antiviral	antiviral	JJ
cord-312001-8p7scli8	18	67	state	state	NN
cord-312001-8p7scli8	18	68	to	to	IN
cord-312001-8p7scli8	18	69	the	the	DT
cord-312001-8p7scli8	18	70	host	host	NN
cord-312001-8p7scli8	19	1	(	(	-LRB-
cord-312001-8p7scli8	19	2	Figure	figure	NN
cord-312001-8p7scli8	19	3	1	1	CD
cord-312001-8p7scli8	19	4	)	)	-RRB-
cord-312001-8p7scli8	19	5	.	.	.
cord-312001-8p7scli8	20	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	20	2	,	,	,
cord-312001-8p7scli8	20	3	a	a	DT
cord-312001-8p7scli8	20	4	closer	close	JJR
cord-312001-8p7scli8	20	5	examination	examination	NN
cord-312001-8p7scli8	20	6	of	of	IN
cord-312001-8p7scli8	20	7	individual	individual	JJ
cord-312001-8p7scli8	20	8	factors	factor	NNS
cord-312001-8p7scli8	20	9	constituting	constitute	VBG
cord-312001-8p7scli8	20	10	these	these	DT
cord-312001-8p7scli8	20	11	pathways	pathway	NNS
cord-312001-8p7scli8	20	12	shows	show	VBZ
cord-312001-8p7scli8	20	13	a	a	DT
cord-312001-8p7scli8	20	14	different	different	JJ
cord-312001-8p7scli8	20	15	conservation	conservation	NN
cord-312001-8p7scli8	20	16	status	status	NN
cord-312001-8p7scli8	20	17	between	between	IN
cord-312001-8p7scli8	20	18	different	different	JJ
cord-312001-8p7scli8	20	19	animal	animal	NN
cord-312001-8p7scli8	20	20	species	specie	NNS
cord-312001-8p7scli8	20	21	.	.	.
cord-312001-8p7scli8	21	1	While	while	IN
cord-312001-8p7scli8	21	2	genes	gene	NNS
cord-312001-8p7scli8	21	3	encoding	encode	VBG
cord-312001-8p7scli8	21	4	sensors	sensor	NNS
cord-312001-8p7scli8	21	5	and	and	CC
cord-312001-8p7scli8	21	6	signaling	signal	VBG
cord-312001-8p7scli8	21	7	platforms	platform	NNS
cord-312001-8p7scli8	21	8	are	be	VBP
cord-312001-8p7scli8	21	9	generally	generally	RB
cord-312001-8p7scli8	21	10	well	well	RB
cord-312001-8p7scli8	21	11	conserved	conserve	VBN
cord-312001-8p7scli8	21	12	amongst	amongst	IN
cord-312001-8p7scli8	21	13	animals	animal	NNS
cord-312001-8p7scli8	21	14	,	,	,
cord-312001-8p7scli8	21	15	virus	virus	NN
cord-312001-8p7scli8	21	16	-	-	HYPH
cord-312001-8p7scli8	21	17	stimulated	stimulate	VBN
cord-312001-8p7scli8	21	18	genes	gene	NNS
cord-312001-8p7scli8	21	19	(	(	-LRB-
cord-312001-8p7scli8	21	20	VSGs	vsg	NNS
cord-312001-8p7scli8	21	21	)	)	-RRB-
cord-312001-8p7scli8	21	22	are	be	VBP
cord-312001-8p7scli8	21	23	clearly	clearly	RB
cord-312001-8p7scli8	21	24	less	less	RBR
cord-312001-8p7scli8	21	25	so	so	RB
cord-312001-8p7scli8	21	26	and	and	CC
cord-312001-8p7scli8	21	27	are	be	VBP
cord-312001-8p7scli8	21	28	subject	subject	JJ
cord-312001-8p7scli8	21	29	to	to	IN
cord-312001-8p7scli8	21	30	faster	fast	JJR
cord-312001-8p7scli8	21	31	evolution	evolution	NN
cord-312001-8p7scli8	21	32	[	[	-LRB-
cord-312001-8p7scli8	21	33	2	2	CD
cord-312001-8p7scli8	21	34	,	,	,
cord-312001-8p7scli8	21	35	3	3	CD
cord-312001-8p7scli8	21	36	]	]	-RRB-
cord-312001-8p7scli8	21	37	.	.	.
cord-312001-8p7scli8	22	1	In	in	IN
cord-312001-8p7scli8	22	2	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	22	3	,	,	,
cord-312001-8p7scli8	22	4	one	one	CD
cord-312001-8p7scli8	22	5	such	such	JJ
cord-312001-8p7scli8	22	6	VSG	VSG	NNP
cord-312001-8p7scli8	22	7	is	be	VBZ
cord-312001-8p7scli8	22	8	the	the	DT
cord-312001-8p7scli8	22	9	secreted	secrete	VBN
cord-312001-8p7scli8	22	10	interferon	interferon	NN
cord-312001-8p7scli8	22	11	(	(	-LRB-
cord-312001-8p7scli8	22	12	IFN	IFN	NNP
cord-312001-8p7scli8	22	13	)	)	-RRB-
cord-312001-8p7scli8	22	14	cytokine	cytokine	NN
cord-312001-8p7scli8	22	15	,	,	,
cord-312001-8p7scli8	22	16	that	that	WDT
cord-312001-8p7scli8	22	17	signals	signal	VBZ
cord-312001-8p7scli8	22	18	in	in	IN
cord-312001-8p7scli8	22	19	an	an	DT
cord-312001-8p7scli8	22	20	autocrine	autocrine	JJ
cord-312001-8p7scli8	22	21	and	and	CC
cord-312001-8p7scli8	22	22	paracrine	paracrine	JJ
cord-312001-8p7scli8	22	23	fashion	fashion	NN
cord-312001-8p7scli8	22	24	.	.	.
cord-312001-8p7scli8	23	1	Secreted	secrete	VBN
cord-312001-8p7scli8	23	2	IFN	IFN	NNP
cord-312001-8p7scli8	23	3	molecules	molecule	NNS
cord-312001-8p7scli8	23	4	bind	bind	VBP
cord-312001-8p7scli8	23	5	to	to	IN
cord-312001-8p7scli8	23	6	cell	cell	NN
cord-312001-8p7scli8	23	7	-	-	HYPH
cord-312001-8p7scli8	23	8	surface	surface	NN
cord-312001-8p7scli8	23	9	receptors	receptor	NNS
cord-312001-8p7scli8	23	10	and	and	CC
cord-312001-8p7scli8	23	11	initiate	initiate	VB
cord-312001-8p7scli8	23	12	signal	signal	NN
cord-312001-8p7scli8	23	13	transduction	transduction	NN
cord-312001-8p7scli8	23	14	involving	involve	VBG
cord-312001-8p7scli8	23	15	the	the	DT
cord-312001-8p7scli8	23	16	Janus	Janus	NNP
cord-312001-8p7scli8	23	17	kinase	kinase	NN
cord-312001-8p7scli8	23	18	/	/	SYM
cord-312001-8p7scli8	23	19	signal	signal	NN
cord-312001-8p7scli8	23	20	transducer	transducer	NN
cord-312001-8p7scli8	23	21	and	and	CC
cord-312001-8p7scli8	23	22	activator	activator	NN
cord-312001-8p7scli8	23	23	of	of	IN
cord-312001-8p7scli8	23	24	transcription	transcription	NN
cord-312001-8p7scli8	23	25	(	(	-LRB-
cord-312001-8p7scli8	23	26	JAK	JAK	NNP
cord-312001-8p7scli8	23	27	-	-	HYPH
cord-312001-8p7scli8	23	28	STAT	STAT	NNP
cord-312001-8p7scli8	23	29	)	)	-RRB-
cord-312001-8p7scli8	23	30	pathway	pathway	NN
cord-312001-8p7scli8	23	31	.	.	.
cord-312001-8p7scli8	24	1	This	this	DT
cord-312001-8p7scli8	24	2	pathway	pathway	NN
cord-312001-8p7scli8	24	3	induces	induce	VBZ
cord-312001-8p7scli8	24	4	the	the	DT
cord-312001-8p7scli8	24	5	transcription	transcription	NN
cord-312001-8p7scli8	24	6	of	of	IN
cord-312001-8p7scli8	24	7	a	a	DT
cord-312001-8p7scli8	24	8	major	major	JJ
cord-312001-8p7scli8	24	9	antiviral	antiviral	JJ
cord-312001-8p7scli8	24	10	program	program	NN
cord-312001-8p7scli8	24	11	composed	compose	VBN
cord-312001-8p7scli8	24	12	of	of	IN
cord-312001-8p7scli8	24	13	hundreds	hundred	NNS
cord-312001-8p7scli8	24	14	of	of	IN
cord-312001-8p7scli8	24	15	so	so	RB
cord-312001-8p7scli8	24	16	-	-	HYPH
cord-312001-8p7scli8	24	17	called	call	VBN
cord-312001-8p7scli8	24	18	IFN	IFN	NNP
cord-312001-8p7scli8	24	19	-	-	HYPH
cord-312001-8p7scli8	24	20	stimulated	stimulate	VBN
cord-312001-8p7scli8	24	21	genes	gene	NNS
cord-312001-8p7scli8	24	22	(	(	-LRB-
cord-312001-8p7scli8	24	23	ISGs	ISGs	NNP
cord-312001-8p7scli8	24	24	)	)	-RRB-
cord-312001-8p7scli8	24	25	that	that	WDT
cord-312001-8p7scli8	24	26	comprise	comprise	VBP
cord-312001-8p7scli8	24	27	effectors	effector	NNS
cord-312001-8p7scli8	24	28	of	of	IN
cord-312001-8p7scli8	24	29	the	the	DT
cord-312001-8p7scli8	24	30	cell	cell	NN
cord-312001-8p7scli8	24	31	-	-	HYPH
cord-312001-8p7scli8	24	32	autonomous	autonomous	JJ
cord-312001-8p7scli8	24	33	antiviral	antiviral	JJ
cord-312001-8p7scli8	24	34	defense	defense	NN
cord-312001-8p7scli8	24	35	[	[	-LRB-
cord-312001-8p7scli8	24	36	4	4	CD
cord-312001-8p7scli8	24	37	]	]	-RRB-
cord-312001-8p7scli8	24	38	.	.	.
cord-312001-8p7scli8	25	1	A	a	DT
cord-312001-8p7scli8	25	2	lot	lot	NN
cord-312001-8p7scli8	25	3	of	of	IN
cord-312001-8p7scli8	25	4	our	-PRON-	PRP$
cord-312001-8p7scli8	25	5	understanding	understanding	NN
cord-312001-8p7scli8	25	6	of	of	IN
cord-312001-8p7scli8	25	7	the	the	DT
cord-312001-8p7scli8	25	8	innate	innate	JJ
cord-312001-8p7scli8	25	9	antiviral	antiviral	JJ
cord-312001-8p7scli8	25	10	immune	immune	JJ
cord-312001-8p7scli8	25	11	system	system	NN
cord-312001-8p7scli8	25	12	in	in	IN
cord-312001-8p7scli8	25	13	animals	animal	NNS
cord-312001-8p7scli8	25	14	is	be	VBZ
cord-312001-8p7scli8	25	15	a	a	DT
cord-312001-8p7scli8	25	16	result	result	NN
cord-312001-8p7scli8	25	17	of	of	IN
cord-312001-8p7scli8	25	18	studies	study	NNS
cord-312001-8p7scli8	25	19	conducted	conduct	VBN
cord-312001-8p7scli8	25	20	in	in	IN
cord-312001-8p7scli8	25	21	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	25	22	and	and	CC
cord-312001-8p7scli8	25	23	more	more	RBR
cord-312001-8p7scli8	25	24	particularly	particularly	RB
cord-312001-8p7scli8	25	25	in	in	IN
cord-312001-8p7scli8	25	26	mammalian	mammalian	JJ
cord-312001-8p7scli8	25	27	species	specie	NNS
cord-312001-8p7scli8	25	28	.	.	.
cord-312001-8p7scli8	26	1	Therefore	therefore	RB
cord-312001-8p7scli8	26	2	,	,	,
cord-312001-8p7scli8	26	3	the	the	DT
cord-312001-8p7scli8	26	4	IFN	IFN	NNP
cord-312001-8p7scli8	26	5	system	system	NN
cord-312001-8p7scli8	26	6	has	have	VBZ
cord-312001-8p7scli8	26	7	been	be	VBN
cord-312001-8p7scli8	26	8	heavily	heavily	RB
cord-312001-8p7scli8	26	9	studied	study	VBN
cord-312001-8p7scli8	26	10	over	over	IN
cord-312001-8p7scli8	26	11	the	the	DT
cord-312001-8p7scli8	26	12	last	last	JJ
cord-312001-8p7scli8	26	13	60	60	CD
cord-312001-8p7scli8	26	14	years	year	NNS
cord-312001-8p7scli8	26	15	.	.	.
cord-312001-8p7scli8	27	1	However	however	RB
cord-312001-8p7scli8	27	2	,	,	,
cord-312001-8p7scli8	27	3	during	during	IN
cord-312001-8p7scli8	27	4	the	the	DT
cord-312001-8p7scli8	27	5	last	last	JJ
cord-312001-8p7scli8	27	6	two	two	CD
cord-312001-8p7scli8	27	7	decades	decade	NNS
cord-312001-8p7scli8	27	8	,	,	,
cord-312001-8p7scli8	27	9	we	-PRON-	PRP
cord-312001-8p7scli8	27	10	came	come	VBD
cord-312001-8p7scli8	27	11	to	to	TO
cord-312001-8p7scli8	27	12	appreciate	appreciate	VB
cord-312001-8p7scli8	27	13	that	that	IN
cord-312001-8p7scli8	27	14	the	the	DT
cord-312001-8p7scli8	27	15	IFN	IFN	NNP
cord-312001-8p7scli8	27	16	system	system	NN
cord-312001-8p7scli8	27	17	,	,	,
cord-312001-8p7scli8	27	18	as	as	IN
cord-312001-8p7scli8	27	19	we	-PRON-	PRP
cord-312001-8p7scli8	27	20	know	know	VBP
cord-312001-8p7scli8	27	21	it	-PRON-	PRP
cord-312001-8p7scli8	27	22	,	,	,
cord-312001-8p7scli8	27	23	is	be	VBZ
cord-312001-8p7scli8	27	24	a	a	DT
cord-312001-8p7scli8	27	25	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	27	26	particularity	particularity	NN
cord-312001-8p7scli8	27	27	.	.	.
cord-312001-8p7scli8	28	1	Indeed	indeed	RB
cord-312001-8p7scli8	28	2	,	,	,
cord-312001-8p7scli8	28	3	while	while	IN
cord-312001-8p7scli8	28	4	some	some	DT
cord-312001-8p7scli8	28	5	animal	animal	NN
cord-312001-8p7scli8	28	6	species	specie	NNS
cord-312001-8p7scli8	28	7	like	like	IN
cord-312001-8p7scli8	28	8	insects	insect	NNS
cord-312001-8p7scli8	28	9	or	or	CC
cord-312001-8p7scli8	28	10	nematodes	nematode	NNS
cord-312001-8p7scli8	28	11	are	be	VBP
cord-312001-8p7scli8	28	12	devoid	devoid	JJ
cord-312001-8p7scli8	28	13	of	of	IN
cord-312001-8p7scli8	28	14	IFNs	ifn	NNS
cord-312001-8p7scli8	28	15	and	and	CC
cord-312001-8p7scli8	28	16	rely	rely	VB
cord-312001-8p7scli8	28	17	on	on	IN
cord-312001-8p7scli8	28	18	RNA	RNA	NNP
cord-312001-8p7scli8	28	19	interference	interference	NN
cord-312001-8p7scli8	28	20	(	(	-LRB-
cord-312001-8p7scli8	28	21	RNAi	RNAi	NNP
cord-312001-8p7scli8	28	22	)	)	-RRB-
cord-312001-8p7scli8	28	23	as	as	IN
cord-312001-8p7scli8	28	24	the	the	DT
cord-312001-8p7scli8	28	25	major	major	JJ
cord-312001-8p7scli8	28	26	antiviral	antiviral	JJ
cord-312001-8p7scli8	28	27	pathway	pathway	NN
cord-312001-8p7scli8	28	28	,	,	,
cord-312001-8p7scli8	28	29	some	some	DT
cord-312001-8p7scli8	28	30	others	other	NNS
cord-312001-8p7scli8	28	31	,	,	,
cord-312001-8p7scli8	28	32	like	like	IN
cord-312001-8p7scli8	28	33	mollusks	mollusk	NNS
cord-312001-8p7scli8	28	34	,	,	,
cord-312001-8p7scli8	28	35	have	have	VBP
cord-312001-8p7scli8	28	36	conserved	conserve	VBN
cord-312001-8p7scli8	28	37	all	all	PDT
cord-312001-8p7scli8	28	38	the	the	DT
cord-312001-8p7scli8	28	39	components	component	NNS
cord-312001-8p7scli8	28	40	that	that	WDT
cord-312001-8p7scli8	28	41	lead	lead	VBP
cord-312001-8p7scli8	28	42	to	to	IN
cord-312001-8p7scli8	28	43	IFN	IFN	NNP
cord-312001-8p7scli8	28	44	production	production	NN
cord-312001-8p7scli8	28	45	but	but	CC
cord-312001-8p7scli8	28	46	have	have	VBP
cord-312001-8p7scli8	28	47	no	no	DT
cord-312001-8p7scli8	28	48	obvious	obvious	JJ
cord-312001-8p7scli8	28	49	homologs	homolog	NNS
cord-312001-8p7scli8	28	50	of	of	IN
cord-312001-8p7scli8	28	51	type	type	NN
cord-312001-8p7scli8	29	1	I	-PRON-	PRP
cord-312001-8p7scli8	29	2	IFN	IFN	NNP
cord-312001-8p7scli8	29	3	cytokines	cytokine	NNS
cord-312001-8p7scli8	29	4	.	.	.
cord-312001-8p7scli8	30	1	Nevertheless	nevertheless	RB
cord-312001-8p7scli8	30	2	,	,	,
cord-312001-8p7scli8	30	3	these	these	DT
cord-312001-8p7scli8	30	4	are	be	VBP
cord-312001-8p7scli8	30	5	predicted	predict	VBN
cord-312001-8p7scli8	30	6	to	to	TO
cord-312001-8p7scli8	30	7	use	use	VB
cord-312001-8p7scli8	30	8	an	an	DT
cord-312001-8p7scli8	30	9	IFN	IFN	NNP
cord-312001-8p7scli8	30	10	-	-	HYPH
cord-312001-8p7scli8	30	11	like	like	JJ
cord-312001-8p7scli8	30	12	antiviral	antiviral	JJ
cord-312001-8p7scli8	30	13	cytokine	cytokine	NN
cord-312001-8p7scli8	30	14	[	[	-LRB-
cord-312001-8p7scli8	30	15	5	5	CD
cord-312001-8p7scli8	30	16	]	]	-RRB-
cord-312001-8p7scli8	30	17	.	.	.
cord-312001-8p7scli8	31	1	In	in	IN
cord-312001-8p7scli8	31	2	fact	fact	NN
cord-312001-8p7scli8	31	3	,	,	,
cord-312001-8p7scli8	31	4	the	the	DT
cord-312001-8p7scli8	31	5	IFN	IFN	NNP
cord-312001-8p7scli8	31	6	cytokine	cytokine	NN
cord-312001-8p7scli8	31	7	itself	-PRON-	PRP
cord-312001-8p7scli8	31	8	seems	seem	VBZ
cord-312001-8p7scli8	31	9	to	to	TO
cord-312001-8p7scli8	31	10	be	be	VB
cord-312001-8p7scli8	31	11	an	an	DT
cord-312001-8p7scli8	31	12	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	31	13	novelty	novelty	NN
cord-312001-8p7scli8	31	14	,	,	,
cord-312001-8p7scli8	31	15	however	however	RB
cord-312001-8p7scli8	31	16	,	,	,
cord-312001-8p7scli8	31	17	the	the	DT
cord-312001-8p7scli8	31	18	pathways	pathway	NNS
cord-312001-8p7scli8	31	19	dictating	dictate	VBG
cord-312001-8p7scli8	31	20	its	-PRON-	PRP$
cord-312001-8p7scli8	31	21	production	production	NN
cord-312001-8p7scli8	31	22	existed	exist	VBD
cord-312001-8p7scli8	31	23	early	early	RB
cord-312001-8p7scli8	31	24	in	in	IN
cord-312001-8p7scli8	31	25	metazoan	metazoan	JJ
cord-312001-8p7scli8	31	26	evolution	evolution	NN
cord-312001-8p7scli8	31	27	[	[	-LRB-
cord-312001-8p7scli8	31	28	3	3	CD
cord-312001-8p7scli8	31	29	,	,	,
cord-312001-8p7scli8	31	30	6	6	CD
cord-312001-8p7scli8	31	31	]	]	-RRB-
cord-312001-8p7scli8	32	1	(	(	-LRB-
cord-312001-8p7scli8	32	2	Figure	figure	NN
cord-312001-8p7scli8	32	3	2	2	CD
cord-312001-8p7scli8	32	4	)	)	-RRB-
cord-312001-8p7scli8	32	5	.	.	.
cord-312001-8p7scli8	33	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	33	2	,	,	,
cord-312001-8p7scli8	33	3	IFN	IFN	NNP
cord-312001-8p7scli8	33	4	is	be	VBZ
cord-312001-8p7scli8	33	5	not	not	RB
cord-312001-8p7scli8	33	6	the	the	DT
cord-312001-8p7scli8	33	7	only	only	JJ
cord-312001-8p7scli8	33	8	VSG	VSG	NNP
cord-312001-8p7scli8	33	9	induced	induce	VBN
cord-312001-8p7scli8	33	10	upon	upon	IN
cord-312001-8p7scli8	33	11	viral	viral	JJ
cord-312001-8p7scli8	33	12	detection	detection	NN
cord-312001-8p7scli8	33	13	in	in	IN
cord-312001-8p7scli8	33	14	mammals	mammal	NNS
cord-312001-8p7scli8	33	15	.	.	.
cord-312001-8p7scli8	34	1	Certain	certain	JJ
cord-312001-8p7scli8	34	2	ISGs	isg	NNS
cord-312001-8p7scli8	34	3	that	that	WDT
cord-312001-8p7scli8	34	4	directly	directly	RB
cord-312001-8p7scli8	34	5	interfere	interfere	VBP
cord-312001-8p7scli8	34	6	with	with	IN
cord-312001-8p7scli8	34	7	the	the	DT
cord-312001-8p7scli8	34	8	viral	viral	JJ
cord-312001-8p7scli8	34	9	life	life	NN
cord-312001-8p7scli8	34	10	cycle	cycle	NN
cord-312001-8p7scli8	34	11	like	like	IN
cord-312001-8p7scli8	34	12	Viperin	Viperin	NNP
cord-312001-8p7scli8	34	13	are	be	VBP
cord-312001-8p7scli8	34	14	also	also	RB
cord-312001-8p7scli8	34	15	immediately	immediately	RB
cord-312001-8p7scli8	34	16	induced	induce	VBN
cord-312001-8p7scli8	34	17	after	after	IN
cord-312001-8p7scli8	34	18	viral	viral	JJ
cord-312001-8p7scli8	34	19	infection	infection	NN
cord-312001-8p7scli8	34	20	in	in	IN
cord-312001-8p7scli8	34	21	an	an	DT
cord-312001-8p7scli8	34	22	IFN	IFN	NNP
cord-312001-8p7scli8	34	23	-	-	HYPH
cord-312001-8p7scli8	34	24	independent	independent	JJ
cord-312001-8p7scli8	34	25	fashion	fashion	NN
cord-312001-8p7scli8	34	26	[	[	-LRB-
cord-312001-8p7scli8	34	27	7	7	CD
cord-312001-8p7scli8	34	28	]	]	-RRB-
cord-312001-8p7scli8	34	29	[	[	-LRB-
cord-312001-8p7scli8	34	30	8	8	CD
cord-312001-8p7scli8	34	31	]	]	-RRB-
cord-312001-8p7scli8	34	32	[	[	-LRB-
cord-312001-8p7scli8	34	33	9	9	CD
cord-312001-8p7scli8	34	34	]	]	-RRB-
cord-312001-8p7scli8	34	35	.	.	.
cord-312001-8p7scli8	35	1	In	in	IN
cord-312001-8p7scli8	35	2	this	this	DT
cord-312001-8p7scli8	35	3	review	review	NN
cord-312001-8p7scli8	35	4	,	,	,
cord-312001-8p7scli8	35	5	we	-PRON-	PRP
cord-312001-8p7scli8	35	6	will	will	MD
cord-312001-8p7scli8	35	7	focus	focus	VB
cord-312001-8p7scli8	35	8	on	on	IN
cord-312001-8p7scli8	35	9	the	the	DT
cord-312001-8p7scli8	35	10	conserved	conserved	JJ
cord-312001-8p7scli8	35	11	pathways	pathway	NNS
cord-312001-8p7scli8	35	12	that	that	WDT
cord-312001-8p7scli8	35	13	are	be	VBP
cord-312001-8p7scli8	35	14	responsible	responsible	JJ
cord-312001-8p7scli8	35	15	for	for	IN
cord-312001-8p7scli8	35	16	sensing	sense	VBG
cord-312001-8p7scli8	35	17	viral	viral	JJ
cord-312001-8p7scli8	35	18	PAMPs	pamp	NNS
cord-312001-8p7scli8	35	19	,	,	,
cord-312001-8p7scli8	35	20	signaling	signal	VBG
cord-312001-8p7scli8	35	21	and	and	CC
cord-312001-8p7scli8	35	22	inducing	induce	VBG
cord-312001-8p7scli8	35	23	antiviral	antiviral	JJ
cord-312001-8p7scli8	35	24	genes	gene	NNS
cord-312001-8p7scli8	35	25	upon	upon	IN
cord-312001-8p7scli8	35	26	infection	infection	NN
cord-312001-8p7scli8	35	27	in	in	IN
cord-312001-8p7scli8	35	28	animals	animal	NNS
cord-312001-8p7scli8	35	29	.	.	.
cord-312001-8p7scli8	36	1	We	-PRON-	PRP
cord-312001-8p7scli8	36	2	will	will	MD
cord-312001-8p7scli8	36	3	start	start	VB
cord-312001-8p7scli8	36	4	by	by	IN
cord-312001-8p7scli8	36	5	describing	describe	VBG
cord-312001-8p7scli8	36	6	our	-PRON-	PRP$
cord-312001-8p7scli8	36	7	current	current	JJ
cord-312001-8p7scli8	36	8	view	view	NN
cord-312001-8p7scli8	36	9	on	on	IN
cord-312001-8p7scli8	36	10	the	the	DT
cord-312001-8p7scli8	36	11	immediate	immediate	JJ
cord-312001-8p7scli8	36	12	activation	activation	NN
cord-312001-8p7scli8	36	13	of	of	IN
cord-312001-8p7scli8	36	14	the	the	DT
cord-312001-8p7scli8	36	15	IFN	IFN	NNP
cord-312001-8p7scli8	36	16	and	and	CC
cord-312001-8p7scli8	36	17	NF	NF	NNP
cord-312001-8p7scli8	36	18	-	-	HYPH
cord-312001-8p7scli8	36	19	kB	kB	NNP
cord-312001-8p7scli8	36	20	pathways	pathway	NNS
cord-312001-8p7scli8	36	21	in	in	IN
cord-312001-8p7scli8	36	22	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	36	23	species	specie	NNS
cord-312001-8p7scli8	36	24	.	.	.
cord-312001-8p7scli8	37	1	We	-PRON-	PRP
cord-312001-8p7scli8	37	2	will	will	MD
cord-312001-8p7scli8	37	3	then	then	RB
cord-312001-8p7scli8	37	4	zoom	zoom	VB
cord-312001-8p7scli8	37	5	in	in	RP
cord-312001-8p7scli8	37	6	on	on	IN
cord-312001-8p7scli8	37	7	two	two	CD
cord-312001-8p7scli8	37	8	important	important	JJ
cord-312001-8p7scli8	37	9	viral	viral	JJ
cord-312001-8p7scli8	37	10	nucleic	nucleic	JJ
cord-312001-8p7scli8	37	11	acid	acid	NN
cord-312001-8p7scli8	37	12	receptor	receptor	NN
cord-312001-8p7scli8	37	13	families	family	NNS
cord-312001-8p7scli8	37	14	,	,	,
cord-312001-8p7scli8	37	15	Toll	toll	NN
cord-312001-8p7scli8	37	16	-	-	HYPH
cord-312001-8p7scli8	37	17	like	like	JJ
cord-312001-8p7scli8	37	18	receptors	receptor	NNS
cord-312001-8p7scli8	37	19	(	(	-LRB-
cord-312001-8p7scli8	37	20	TLRs	TLRs	NNP
cord-312001-8p7scli8	37	21	)	)	-RRB-
cord-312001-8p7scli8	37	22	and	and	CC
cord-312001-8p7scli8	37	23	RIG	rig	NN
cord-312001-8p7scli8	37	24	-	-	HYPH
cord-312001-8p7scli8	37	25	I	i	NN
cord-312001-8p7scli8	37	26	-	-	HYPH
cord-312001-8p7scli8	37	27	like	like	JJ
cord-312001-8p7scli8	37	28	receptors	receptor	NNS
cord-312001-8p7scli8	37	29	(	(	-LRB-
cord-312001-8p7scli8	37	30	RLRs	RLRs	NNP
cord-312001-8p7scli8	37	31	)	)	-RRB-
cord-312001-8p7scli8	37	32	,	,	,
cord-312001-8p7scli8	37	33	describe	describe	VBP
cord-312001-8p7scli8	37	34	their	-PRON-	PRP$
cord-312001-8p7scli8	37	35	function	function	NN
cord-312001-8p7scli8	37	36	in	in	IN
cord-312001-8p7scli8	37	37	viral	viral	JJ
cord-312001-8p7scli8	37	38	RNA	RNA	NNP
cord-312001-8p7scli8	37	39	detection	detection	NN
cord-312001-8p7scli8	37	40	and	and	CC
cord-312001-8p7scli8	37	41	their	-PRON-	PRP$
cord-312001-8p7scli8	37	42	conservation	conservation	NN
cord-312001-8p7scli8	37	43	across	across	IN
cord-312001-8p7scli8	37	44	animal	animal	NN
cord-312001-8p7scli8	37	45	species	specie	NNS
cord-312001-8p7scli8	37	46	.	.	.
cord-312001-8p7scli8	38	1	Next	next	RB
cord-312001-8p7scli8	38	2	,	,	,
cord-312001-8p7scli8	38	3	we	-PRON-	PRP
cord-312001-8p7scli8	38	4	will	will	MD
cord-312001-8p7scli8	38	5	focus	focus	VB
cord-312001-8p7scli8	38	6	on	on	IN
cord-312001-8p7scli8	38	7	a	a	DT
cord-312001-8p7scli8	38	8	central	central	JJ
cord-312001-8p7scli8	38	9	hub	hub	NN
cord-312001-8p7scli8	38	10	in	in	IN
cord-312001-8p7scli8	38	11	the	the	DT
cord-312001-8p7scli8	38	12	signaling	signal	VBG
cord-312001-8p7scli8	38	13	pathways	pathway	NNS
cord-312001-8p7scli8	38	14	induced	induce	VBN
cord-312001-8p7scli8	38	15	by	by	IN
cord-312001-8p7scli8	38	16	DNA	DNA	NNP
cord-312001-8p7scli8	38	17	viruses	virus	NNS
cord-312001-8p7scli8	38	18	,	,	,
cord-312001-8p7scli8	38	19	the	the	DT
cord-312001-8p7scli8	38	20	stimulator	stimulator	NN
cord-312001-8p7scli8	38	21	of	of	IN
cord-312001-8p7scli8	38	22	IFN	IFN	NNP
cord-312001-8p7scli8	38	23	genes	gene	NNS
cord-312001-8p7scli8	38	24	(	(	-LRB-
cord-312001-8p7scli8	38	25	STING	sting	NN
cord-312001-8p7scli8	38	26	)	)	-RRB-
cord-312001-8p7scli8	38	27	.	.	.
cord-312001-8p7scli8	39	1	We	-PRON-	PRP
cord-312001-8p7scli8	39	2	will	will	MD
cord-312001-8p7scli8	39	3	then	then	RB
cord-312001-8p7scli8	39	4	examine	examine	VB
cord-312001-8p7scli8	39	5	how	how	WRB
cord-312001-8p7scli8	39	6	the	the	DT
cord-312001-8p7scli8	39	7	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	39	8	conflicts	conflict	NNS
cord-312001-8p7scli8	39	9	between	between	IN
cord-312001-8p7scli8	39	10	viruses	virus	NNS
cord-312001-8p7scli8	39	11	and	and	CC
cord-312001-8p7scli8	39	12	host	host	NN
cord-312001-8p7scli8	39	13	immune	immune	JJ
cord-312001-8p7scli8	39	14	factors	factor	NNS
cord-312001-8p7scli8	39	15	are	be	VBP
cord-312001-8p7scli8	39	16	shaping	shape	VBG
cord-312001-8p7scli8	39	17	antiviral	antiviral	JJ
cord-312001-8p7scli8	39	18	immunity	immunity	NN
cord-312001-8p7scli8	39	19	in	in	IN
cord-312001-8p7scli8	39	20	animals	animal	NNS
cord-312001-8p7scli8	39	21	.	.	.
cord-312001-8p7scli8	40	1	Viruses	virus	NNS
cord-312001-8p7scli8	40	2	and	and	CC
cord-312001-8p7scli8	40	3	transposable	transposable	JJ
cord-312001-8p7scli8	40	4	elements	element	NNS
cord-312001-8p7scli8	40	5	are	be	VBP
cord-312001-8p7scli8	40	6	very	very	RB
cord-312001-8p7scli8	40	7	powerful	powerful	JJ
cord-312001-8p7scli8	40	8	drivers	driver	NNS
cord-312001-8p7scli8	40	9	of	of	IN
cord-312001-8p7scli8	40	10	evolution	evolution	NN
cord-312001-8p7scli8	40	11	[	[	-LRB-
cord-312001-8p7scli8	40	12	1	1	CD
cord-312001-8p7scli8	40	13	,	,	,
cord-312001-8p7scli8	40	14	19	19	CD
cord-312001-8p7scli8	40	15	]	]	-RRB-
cord-312001-8p7scli8	40	16	.	.	.
cord-312001-8p7scli8	41	1	However	however	RB
cord-312001-8p7scli8	41	2	,	,	,
cord-312001-8p7scli8	41	3	their	-PRON-	PRP$
cord-312001-8p7scli8	41	4	uncontrolled	uncontrolled	JJ
cord-312001-8p7scli8	41	5	replication	replication	NN
cord-312001-8p7scli8	41	6	and	and	CC
cord-312001-8p7scli8	41	7	spread	spread	NN
cord-312001-8p7scli8	41	8	can	can	MD
cord-312001-8p7scli8	41	9	be	be	VB
cord-312001-8p7scli8	41	10	catastrophic	catastrophic	JJ
cord-312001-8p7scli8	41	11	to	to	TO
cord-312001-8p7scli8	41	12	host	host	NN
cord-312001-8p7scli8	41	13	cells	cell	NNS
cord-312001-8p7scli8	41	14	.	.	.
cord-312001-8p7scli8	42	1	It	-PRON-	PRP
cord-312001-8p7scli8	42	2	is	be	VBZ
cord-312001-8p7scli8	42	3	therefore	therefore	RB
cord-312001-8p7scli8	42	4	not	not	RB
cord-312001-8p7scli8	42	5	surprising	surprising	JJ
cord-312001-8p7scli8	42	6	that	that	IN
cord-312001-8p7scli8	42	7	every	every	DT
cord-312001-8p7scli8	42	8	known	know	VBN
cord-312001-8p7scli8	42	9	living	live	VBG
cord-312001-8p7scli8	42	10	species	specie	NNS
cord-312001-8p7scli8	42	11	on	on	IN
cord-312001-8p7scli8	42	12	the	the	DT
cord-312001-8p7scli8	42	13	planet	planet	NN
cord-312001-8p7scli8	42	14	has	have	VBZ
cord-312001-8p7scli8	42	15	evolved	evolve	VBN
cord-312001-8p7scli8	42	16	measures	measure	NNS
cord-312001-8p7scli8	42	17	to	to	TO
cord-312001-8p7scli8	42	18	recognize	recognize	VB
cord-312001-8p7scli8	42	19	and	and	CC
cord-312001-8p7scli8	42	20	counteract	counteract	VB
cord-312001-8p7scli8	42	21	parasitic	parasitic	JJ
cord-312001-8p7scli8	42	22	genetic	genetic	JJ
cord-312001-8p7scli8	42	23	elements	element	NNS
cord-312001-8p7scli8	42	24	.	.	.
cord-312001-8p7scli8	43	1	It	-PRON-	PRP
cord-312001-8p7scli8	43	2	is	be	VBZ
cord-312001-8p7scli8	43	3	suggested	suggest	VBN
cord-312001-8p7scli8	43	4	that	that	IN
cord-312001-8p7scli8	43	5	anti	anti	JJ
cord-312001-8p7scli8	43	6	-	-	NN
cord-312001-8p7scli8	43	7	sense	sense	JJ
cord-312001-8p7scli8	43	8	mediated	mediate	VBN
cord-312001-8p7scli8	43	9	targeting	targeting	NN
cord-312001-8p7scli8	43	10	of	of	IN
cord-312001-8p7scli8	43	11	viral	viral	JJ
cord-312001-8p7scli8	43	12	nucleic	nucleic	JJ
cord-312001-8p7scli8	43	13	acids	acid	NNS
cord-312001-8p7scli8	43	14	was	be	VBD
cord-312001-8p7scli8	43	15	the	the	DT
cord-312001-8p7scli8	43	16	most	most	RBS
cord-312001-8p7scli8	43	17	primordial	primordial	JJ
cord-312001-8p7scli8	43	18	strategy	strategy	NN
cord-312001-8p7scli8	43	19	protocells	protocell	NNS
cord-312001-8p7scli8	43	20	used	use	VBD
cord-312001-8p7scli8	43	21	to	to	TO
cord-312001-8p7scli8	43	22	fend	fend	VB
cord-312001-8p7scli8	43	23	off	off	RP
cord-312001-8p7scli8	43	24	viral	viral	JJ
cord-312001-8p7scli8	43	25	threats	threat	NNS
cord-312001-8p7scli8	43	26	[	[	-LRB-
cord-312001-8p7scli8	43	27	18	18	CD
cord-312001-8p7scli8	43	28	]	]	-RRB-
cord-312001-8p7scli8	43	29	.	.	.
cord-312001-8p7scli8	44	1	This	this	DT
cord-312001-8p7scli8	44	2	is	be	VBZ
cord-312001-8p7scli8	44	3	illustrated	illustrate	VBN
cord-312001-8p7scli8	44	4	by	by	IN
cord-312001-8p7scli8	44	5	Argonaute	Argonaute	NNP
cord-312001-8p7scli8	44	6	and	and	CC
cord-312001-8p7scli8	44	7	CRISPR	CRISPR	NNP
cord-312001-8p7scli8	44	8	-	-	HYPH
cord-312001-8p7scli8	44	9	based	base	VBN
cord-312001-8p7scli8	44	10	defenses	defense	NNS
cord-312001-8p7scli8	44	11	in	in	IN
cord-312001-8p7scli8	44	12	bacteria	bacteria	NNS
cord-312001-8p7scli8	44	13	,	,	,
cord-312001-8p7scli8	44	14	archaea	archaea	NNS
cord-312001-8p7scli8	44	15	and	and	CC
cord-312001-8p7scli8	44	16	RNAi	RNAi	NNP
cord-312001-8p7scli8	44	17	systems	system	NNS
cord-312001-8p7scli8	44	18	in	in	IN
cord-312001-8p7scli8	44	19	plants	plant	NNS
cord-312001-8p7scli8	44	20	,	,	,
cord-312001-8p7scli8	44	21	all	all	DT
cord-312001-8p7scli8	44	22	of	of	IN
cord-312001-8p7scli8	44	23	which	which	WDT
cord-312001-8p7scli8	44	24	rely	rely	VBP
cord-312001-8p7scli8	44	25	on	on	IN
cord-312001-8p7scli8	44	26	anti	anti	JJ
cord-312001-8p7scli8	44	27	-	-	JJ
cord-312001-8p7scli8	44	28	sense	sense	JJ
cord-312001-8p7scli8	44	29	nucleic	nucleic	JJ
cord-312001-8p7scli8	44	30	acids	acid	NNS
cord-312001-8p7scli8	44	31	that	that	WDT
cord-312001-8p7scli8	44	32	program	program	VBP
cord-312001-8p7scli8	44	33	a	a	DT
cord-312001-8p7scli8	44	34	nuclease	nuclease	NN
cord-312001-8p7scli8	44	35	to	to	TO
cord-312001-8p7scli8	44	36	target	target	VB
cord-312001-8p7scli8	44	37	and	and	CC
cord-312001-8p7scli8	44	38	degrade	degrade	VB
cord-312001-8p7scli8	44	39	the	the	DT
cord-312001-8p7scli8	44	40	complementary	complementary	JJ
cord-312001-8p7scli8	44	41	invading	invade	VBG
cord-312001-8p7scli8	44	42	viral	viral	JJ
cord-312001-8p7scli8	44	43	genome	genome	NN
cord-312001-8p7scli8	44	44	[	[	-LRB-
cord-312001-8p7scli8	44	45	20	20	CD
cord-312001-8p7scli8	44	46	]	]	-RRB-
cord-312001-8p7scli8	44	47	[	[	-LRB-
cord-312001-8p7scli8	44	48	21	21	CD
cord-312001-8p7scli8	44	49	]	]	-RRB-
cord-312001-8p7scli8	44	50	[	[	-LRB-
cord-312001-8p7scli8	44	51	22	22	CD
cord-312001-8p7scli8	44	52	]	]	-RRB-
cord-312001-8p7scli8	44	53	.	.	.
cord-312001-8p7scli8	45	1	Because	because	IN
cord-312001-8p7scli8	45	2	many	many	JJ
cord-312001-8p7scli8	45	3	of	of	IN
cord-312001-8p7scli8	45	4	the	the	DT
cord-312001-8p7scli8	45	5	core	core	NN
cord-312001-8p7scli8	45	6	RNAi	RNAi	NNP
cord-312001-8p7scli8	45	7	machinery	machinery	NN
cord-312001-8p7scli8	45	8	components	component	NNS
cord-312001-8p7scli8	45	9	can	can	MD
cord-312001-8p7scli8	45	10	be	be	VB
cord-312001-8p7scli8	45	11	found	find	VBN
cord-312001-8p7scli8	45	12	in	in	IN
cord-312001-8p7scli8	45	13	all	all	DT
cord-312001-8p7scli8	45	14	eukaryotic	eukaryotic	JJ
cord-312001-8p7scli8	45	15	superkingdoms	superkingdom	NNS
cord-312001-8p7scli8	45	16	,	,	,
cord-312001-8p7scli8	45	17	it	-PRON-	PRP
cord-312001-8p7scli8	45	18	is	be	VBZ
cord-312001-8p7scli8	45	19	thought	think	VBN
cord-312001-8p7scli8	45	20	that	that	IN
cord-312001-8p7scli8	45	21	this	this	DT
cord-312001-8p7scli8	45	22	antiviral	antiviral	JJ
cord-312001-8p7scli8	45	23	defense	defense	NN
cord-312001-8p7scli8	45	24	mechanism	mechanism	NN
cord-312001-8p7scli8	45	25	predated	predate	VBD
cord-312001-8p7scli8	45	26	the	the	DT
cord-312001-8p7scli8	45	27	emergence	emergence	NN
cord-312001-8p7scli8	45	28	of	of	IN
cord-312001-8p7scli8	45	29	pattern	pattern	NN
cord-312001-8p7scli8	45	30	-	-	HYPH
cord-312001-8p7scli8	45	31	recognition	recognition	NN
cord-312001-8p7scli8	45	32	receptor	receptor	NN
cord-312001-8p7scli8	45	33	(	(	-LRB-
cord-312001-8p7scli8	45	34	PRR)-based	prr)-based	JJ
cord-312001-8p7scli8	45	35	immunity	immunity	NN
cord-312001-8p7scli8	45	36	(	(	-LRB-
cord-312001-8p7scli8	45	37	Figure	figure	NN
cord-312001-8p7scli8	45	38	2	2	CD
cord-312001-8p7scli8	45	39	)	)	-RRB-
cord-312001-8p7scli8	45	40	[	[	-LRB-
cord-312001-8p7scli8	45	41	23	23	CD
cord-312001-8p7scli8	45	42	]	]	-RRB-
cord-312001-8p7scli8	45	43	.	.	.
cord-312001-8p7scli8	46	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	46	2	,	,	,
cord-312001-8p7scli8	46	3	antiviral	antiviral	JJ
cord-312001-8p7scli8	46	4	defense	defense	NN
cord-312001-8p7scli8	46	5	in	in	IN
cord-312001-8p7scli8	46	6	eukaryotes	eukaryote	NNS
cord-312001-8p7scli8	46	7	has	have	VBZ
cord-312001-8p7scli8	46	8	diversified	diversify	VBN
cord-312001-8p7scli8	46	9	greatly	greatly	RB
cord-312001-8p7scli8	46	10	during	during	IN
cord-312001-8p7scli8	46	11	evolution	evolution	NN
cord-312001-8p7scli8	46	12	,	,	,
cord-312001-8p7scli8	46	13	with	with	IN
cord-312001-8p7scli8	46	14	some	some	DT
cord-312001-8p7scli8	46	15	species	specie	NNS
cord-312001-8p7scli8	46	16	maintaining	maintain	VBG
cord-312001-8p7scli8	46	17	RNAi	rnai	NN
cord-312001-8p7scli8	46	18	-	-	HYPH
cord-312001-8p7scli8	46	19	based	base	VBN
cord-312001-8p7scli8	46	20	defenses	defense	NNS
cord-312001-8p7scli8	46	21	[	[	-LRB-
cord-312001-8p7scli8	46	22	24	24	CD
cord-312001-8p7scli8	46	23	]	]	-RRB-
cord-312001-8p7scli8	46	24	and	and	CC
cord-312001-8p7scli8	46	25	others	other	NNS
cord-312001-8p7scli8	46	26	innovating	innovate	VBG
cord-312001-8p7scli8	46	27	and	and	CC
cord-312001-8p7scli8	46	28	adopting	adopt	VBG
cord-312001-8p7scli8	46	29	completely	completely	RB
cord-312001-8p7scli8	46	30	novel	novel	JJ
cord-312001-8p7scli8	46	31	antiviral	antiviral	JJ
cord-312001-8p7scli8	46	32	strategies	strategy	NNS
cord-312001-8p7scli8	46	33	.	.	.
cord-312001-8p7scli8	47	1	In	in	IN
cord-312001-8p7scli8	47	2	chordates	chordate	NNS
cord-312001-8p7scli8	47	3	and	and	CC
cord-312001-8p7scli8	47	4	more	more	RBR
cord-312001-8p7scli8	47	5	particularly	particularly	RB
cord-312001-8p7scli8	47	6	in	in	IN
cord-312001-8p7scli8	47	7	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	47	8	animals	animal	NNS
cord-312001-8p7scli8	47	9	,	,	,
cord-312001-8p7scli8	47	10	the	the	DT
cord-312001-8p7scli8	47	11	emergence	emergence	NN
cord-312001-8p7scli8	47	12	of	of	IN
cord-312001-8p7scli8	47	13	IFN	IFN	NNP
cord-312001-8p7scli8	47	14	-	-	HYPH
cord-312001-8p7scli8	47	15	I	I	NNP
cord-312001-8p7scli8	47	16	and	and	CC
cord-312001-8p7scli8	47	17	a	a	DT
cord-312001-8p7scli8	47	18	recombinational	recombinational	JJ
cord-312001-8p7scli8	47	19	adaptive	adaptive	JJ
cord-312001-8p7scli8	47	20	immune	immune	JJ
cord-312001-8p7scli8	47	21	system	system	NN
cord-312001-8p7scli8	47	22	seems	seem	VBZ
cord-312001-8p7scli8	47	23	to	to	TO
cord-312001-8p7scli8	47	24	coincide	coincide	VB
cord-312001-8p7scli8	47	25	with	with	IN
cord-312001-8p7scli8	47	26	the	the	DT
cord-312001-8p7scli8	47	27	loss	loss	NN
cord-312001-8p7scli8	47	28	of	of	IN
cord-312001-8p7scli8	47	29	RNAi	RNAi	NNS
cord-312001-8p7scli8	47	30	as	as	IN
cord-312001-8p7scli8	47	31	the	the	DT
cord-312001-8p7scli8	47	32	main	main	JJ
cord-312001-8p7scli8	47	33	antiviral	antiviral	JJ
cord-312001-8p7scli8	47	34	mechanism	mechanism	NN
cord-312001-8p7scli8	47	35	in	in	IN
cord-312001-8p7scli8	47	36	somatic	somatic	JJ
cord-312001-8p7scli8	47	37	cells	cell	NNS
cord-312001-8p7scli8	47	38	.	.	.
cord-312001-8p7scli8	48	1	There	there	EX
cord-312001-8p7scli8	48	2	is	be	VBZ
cord-312001-8p7scli8	48	3	strong	strong	JJ
cord-312001-8p7scli8	48	4	evidence	evidence	NN
cord-312001-8p7scli8	48	5	of	of	IN
cord-312001-8p7scli8	48	6	an	an	DT
cord-312001-8p7scli8	48	7	intrinsic	intrinsic	JJ
cord-312001-8p7scli8	48	8	incompatibility	incompatibility	NN
cord-312001-8p7scli8	48	9	between	between	IN
cord-312001-8p7scli8	48	10	an	an	DT
cord-312001-8p7scli8	48	11	antiviral	antiviral	JJ
cord-312001-8p7scli8	48	12	RNAi	RNAi	NNS
cord-312001-8p7scli8	48	13	and	and	CC
cord-312001-8p7scli8	48	14	the	the	DT
cord-312001-8p7scli8	48	15	PRR	PRR	NNP
cord-312001-8p7scli8	48	16	-	-	HYPH
cord-312001-8p7scli8	48	17	IFN	IFN	NNP
cord-312001-8p7scli8	48	18	system	system	NN
cord-312001-8p7scli8	48	19	.	.	.
cord-312001-8p7scli8	49	1	For	for	IN
cord-312001-8p7scli8	49	2	instance	instance	NN
cord-312001-8p7scli8	49	3	,	,	,
cord-312001-8p7scli8	49	4	while	while	IN
cord-312001-8p7scli8	49	5	long	long	JJ
cord-312001-8p7scli8	49	6	dsRNAs	dsRNAs	NNP
cord-312001-8p7scli8	49	7	can	can	MD
cord-312001-8p7scli8	49	8	produce	produce	VB
cord-312001-8p7scli8	49	9	functional	functional	JJ
cord-312001-8p7scli8	49	10	small	small	JJ
cord-312001-8p7scli8	49	11	interfering	interfere	VBG
cord-312001-8p7scli8	49	12	RNAs	rna	NNS
cord-312001-8p7scli8	49	13	(	(	-LRB-
cord-312001-8p7scli8	49	14	siRNAs	siRNAs	NNP
cord-312001-8p7scli8	49	15	)	)	-RRB-
cord-312001-8p7scli8	49	16	in	in	IN
cord-312001-8p7scli8	49	17	stem	stem	NN
cord-312001-8p7scli8	49	18	cells	cell	NNS
cord-312001-8p7scli8	49	19	in	in	IN
cord-312001-8p7scli8	49	20	the	the	DT
cord-312001-8p7scli8	49	21	absence	absence	NN
cord-312001-8p7scli8	49	22	of	of	IN
cord-312001-8p7scli8	49	23	IFN	IFN	NNP
cord-312001-8p7scli8	49	24	,	,	,
cord-312001-8p7scli8	49	25	the	the	DT
cord-312001-8p7scli8	49	26	same	same	JJ
cord-312001-8p7scli8	49	27	dsRNA	dsrna	NN
cord-312001-8p7scli8	49	28	molecule	molecule	NN
cord-312001-8p7scli8	49	29	is	be	VBZ
cord-312001-8p7scli8	49	30	not	not	RB
cord-312001-8p7scli8	49	31	processed	process	VBN
cord-312001-8p7scli8	49	32	onto	onto	IN
cord-312001-8p7scli8	49	33	siRNA	siRNA	NNP
cord-312001-8p7scli8	49	34	and	and	CC
cord-312001-8p7scli8	49	35	is	be	VBZ
cord-312001-8p7scli8	49	36	sensed	sense	VBN
cord-312001-8p7scli8	49	37	as	as	IN
cord-312001-8p7scli8	49	38	a	a	DT
cord-312001-8p7scli8	49	39	PAMP	pamp	NN
cord-312001-8p7scli8	49	40	in	in	IN
cord-312001-8p7scli8	49	41	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	49	42	somatic	somatic	JJ
cord-312001-8p7scli8	49	43	cells	cell	NNS
cord-312001-8p7scli8	49	44	[	[	-LRB-
cord-312001-8p7scli8	49	45	25	25	CD
cord-312001-8p7scli8	49	46	,	,	,
cord-312001-8p7scli8	49	47	26	26	CD
cord-312001-8p7scli8	49	48	]	]	-RRB-
cord-312001-8p7scli8	49	49	.	.	.
cord-312001-8p7scli8	50	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	50	2	,	,	,
cord-312001-8p7scli8	50	3	experimental	experimental	JJ
cord-312001-8p7scli8	50	4	evidence	evidence	NN
cord-312001-8p7scli8	50	5	of	of	IN
cord-312001-8p7scli8	50	6	antiviral	antiviral	JJ
cord-312001-8p7scli8	50	7	RNAi	RNAi	NNS
cord-312001-8p7scli8	50	8	in	in	IN
cord-312001-8p7scli8	50	9	mammals	mammal	NNS
cord-312001-8p7scli8	50	10	seems	seem	VBZ
cord-312001-8p7scli8	50	11	to	to	TO
cord-312001-8p7scli8	50	12	be	be	VB
cord-312001-8p7scli8	50	13	limited	limit	VBN
cord-312001-8p7scli8	50	14	to	to	IN
cord-312001-8p7scli8	50	15	specialized	specialized	JJ
cord-312001-8p7scli8	50	16	pluripotent	pluripotent	JJ
cord-312001-8p7scli8	50	17	cells	cell	NNS
cord-312001-8p7scli8	50	18	in	in	IN
cord-312001-8p7scli8	50	19	which	which	WDT
cord-312001-8p7scli8	50	20	the	the	DT
cord-312001-8p7scli8	50	21	PRR	PRR	NNP
cord-312001-8p7scli8	50	22	-	-	HYPH
cord-312001-8p7scli8	50	23	IFN	IFN	NNP
cord-312001-8p7scli8	50	24	system	system	NN
cord-312001-8p7scli8	50	25	is	be	VBZ
cord-312001-8p7scli8	50	26	not	not	RB
cord-312001-8p7scli8	50	27	fully	fully	RB
cord-312001-8p7scli8	50	28	deployed	deploy	VBN
cord-312001-8p7scli8	50	29	yet	yet	RB
cord-312001-8p7scli8	50	30	.	.	.
cord-312001-8p7scli8	51	1	The	the	DT
cord-312001-8p7scli8	51	2	emergence	emergence	NN
cord-312001-8p7scli8	51	3	of	of	IN
cord-312001-8p7scli8	51	4	both	both	CC
cord-312001-8p7scli8	51	5	the	the	DT
cord-312001-8p7scli8	51	6	IFN	IFN	NNP
cord-312001-8p7scli8	51	7	-	-	HYPH
cord-312001-8p7scli8	51	8	I	I	NNP
cord-312001-8p7scli8	51	9	(	(	-LRB-
cord-312001-8p7scli8	51	10	innate	innate	JJ
cord-312001-8p7scli8	51	11	)	)	-RRB-
cord-312001-8p7scli8	51	12	and	and	CC
cord-312001-8p7scli8	51	13	somatic	somatic	JJ
cord-312001-8p7scli8	51	14	DNA	dna	NN
cord-312001-8p7scli8	51	15	recombination	recombination	NN
cord-312001-8p7scli8	51	16	systems	system	NNS
cord-312001-8p7scli8	51	17	(	(	-LRB-
cord-312001-8p7scli8	51	18	adaptive	adaptive	JJ
cord-312001-8p7scli8	51	19	)	)	-RRB-
cord-312001-8p7scli8	51	20	in	in	IN
cord-312001-8p7scli8	51	21	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	51	22	constituted	constitute	VBD
cord-312001-8p7scli8	51	23	a	a	DT
cord-312001-8p7scli8	51	24	major	major	JJ
cord-312001-8p7scli8	51	25	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	51	26	event	event	NN
cord-312001-8p7scli8	51	27	that	that	WDT
cord-312001-8p7scli8	51	28	dispensed	dispense	VBD
cord-312001-8p7scli8	51	29	them	-PRON-	PRP
cord-312001-8p7scli8	51	30	from	from	IN
cord-312001-8p7scli8	51	31	using	use	VBG
cord-312001-8p7scli8	51	32	RNAi	RNAi	NNS
cord-312001-8p7scli8	51	33	for	for	IN
cord-312001-8p7scli8	51	34	antiviral	antiviral	JJ
cord-312001-8p7scli8	51	35	purposes	purpose	NNS
cord-312001-8p7scli8	51	36	.	.	.
cord-312001-8p7scli8	52	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	52	2	,	,	,
cord-312001-8p7scli8	52	3	retrotransposition	retrotransposition	NN
cord-312001-8p7scli8	52	4	and	and	CC
cord-312001-8p7scli8	52	5	selfish	selfish	JJ
cord-312001-8p7scli8	52	6	transposable	transposable	JJ
cord-312001-8p7scli8	52	7	elements	element	NNS
cord-312001-8p7scli8	52	8	were	be	VBD
cord-312001-8p7scli8	52	9	determinants	determinant	NNS
cord-312001-8p7scli8	52	10	in	in	IN
cord-312001-8p7scli8	52	11	the	the	DT
cord-312001-8p7scli8	52	12	acquisition	acquisition	NN
cord-312001-8p7scli8	52	13	of	of	IN
cord-312001-8p7scli8	52	14	these	these	DT
cord-312001-8p7scli8	52	15	two	two	CD
cord-312001-8p7scli8	52	16	systems	system	NNS
cord-312001-8p7scli8	52	17	[	[	-LRB-
cord-312001-8p7scli8	52	18	3	3	CD
cord-312001-8p7scli8	52	19	,	,	,
cord-312001-8p7scli8	52	20	[	[	-LRB-
cord-312001-8p7scli8	52	21	27	27	CD
cord-312001-8p7scli8	52	22	]	]	-RRB-
cord-312001-8p7scli8	52	23	[	[	-LRB-
cord-312001-8p7scli8	52	24	28	28	CD
cord-312001-8p7scli8	52	25	]	]	-RRB-
cord-312001-8p7scli8	52	26	[	[	-LRB-
cord-312001-8p7scli8	52	27	29	29	CD
cord-312001-8p7scli8	52	28	]	]	-RRB-
cord-312001-8p7scli8	52	29	.	.	.
cord-312001-8p7scli8	53	1	The	the	DT
cord-312001-8p7scli8	53	2	emergence	emergence	NN
cord-312001-8p7scli8	53	3	of	of	IN
cord-312001-8p7scli8	53	4	somatic	somatic	JJ
cord-312001-8p7scli8	53	5	DNA	dna	NN
cord-312001-8p7scli8	53	6	recombination	recombination	NN
cord-312001-8p7scli8	53	7	in	in	IN
cord-312001-8p7scli8	53	8	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	53	9	animals	animal	NNS
cord-312001-8p7scli8	53	10	was	be	VBD
cord-312001-8p7scli8	53	11	considered	consider	VBN
cord-312001-8p7scli8	53	12	an	an	DT
cord-312001-8p7scli8	53	13	"	"	``
cord-312001-8p7scli8	53	14	immunological	immunological	JJ
cord-312001-8p7scli8	53	15	Big	Big	NNP
cord-312001-8p7scli8	53	16	Bang	Bang	NNP
cord-312001-8p7scli8	53	17	"	"	''
cord-312001-8p7scli8	53	18	[	[	-LRB-
cord-312001-8p7scli8	53	19	28	28	CD
cord-312001-8p7scli8	53	20	,	,	,
cord-312001-8p7scli8	53	21	30	30	CD
cord-312001-8p7scli8	53	22	]	]	-RRB-
cord-312001-8p7scli8	53	23	.	.	.
cord-312001-8p7scli8	54	1	Indeed	indeed	RB
cord-312001-8p7scli8	54	2	,	,	,
cord-312001-8p7scli8	54	3	somatic	somatic	JJ
cord-312001-8p7scli8	54	4	DNA	dna	NN
cord-312001-8p7scli8	54	5	recombination	recombination	NN
cord-312001-8p7scli8	54	6	in	in	IN
cord-312001-8p7scli8	54	7	specialized	specialized	NNP
cord-312001-8p7scli8	54	8	B	B	NNP
cord-312001-8p7scli8	54	9	and	and	CC
cord-312001-8p7scli8	54	10	T	T	NNP
cord-312001-8p7scli8	54	11	cell	cell	NN
cord-312001-8p7scli8	54	12	lineages	lineage	NNS
cord-312001-8p7scli8	54	13	provided	provide	VBD
cord-312001-8p7scli8	54	14	jawed	jawed	JJ
cord-312001-8p7scli8	54	15	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	54	16	with	with	IN
cord-312001-8p7scli8	54	17	large	large	JJ
cord-312001-8p7scli8	54	18	repertoires	repertoire	NNS
cord-312001-8p7scli8	54	19	of	of	IN
cord-312001-8p7scli8	54	20	major	major	JJ
cord-312001-8p7scli8	54	21	histocompatibility	histocompatibility	NN
cord-312001-8p7scli8	54	22	complexes	complex	NNS
cord-312001-8p7scli8	54	23	(	(	-LRB-
cord-312001-8p7scli8	54	24	MHC	MHC	NNP
cord-312001-8p7scli8	54	25	)	)	-RRB-
cord-312001-8p7scli8	54	26	,	,	,
cord-312001-8p7scli8	54	27	T	t	NN
cord-312001-8p7scli8	54	28	-	-	HYPH
cord-312001-8p7scli8	54	29	cell	cell	NN
cord-312001-8p7scli8	54	30	receptors	receptor	NNS
cord-312001-8p7scli8	54	31	(	(	-LRB-
cord-312001-8p7scli8	54	32	TCRs	TCRs	NNP
cord-312001-8p7scli8	54	33	)	)	-RRB-
cord-312001-8p7scli8	54	34	and	and	CC
cord-312001-8p7scli8	54	35	immunoglobulins	immunoglobulin	NNS
cord-312001-8p7scli8	54	36	(	(	-LRB-
cord-312001-8p7scli8	54	37	Igs	Igs	NNP
cord-312001-8p7scli8	54	38	)	)	-RRB-
cord-312001-8p7scli8	54	39	.	.	.
cord-312001-8p7scli8	55	1	Until	until	IN
cord-312001-8p7scli8	55	2	relatively	relatively	RB
cord-312001-8p7scli8	55	3	recently	recently	RB
cord-312001-8p7scli8	55	4	,	,	,
cord-312001-8p7scli8	55	5	adaptive	adaptive	JJ
cord-312001-8p7scli8	55	6	immunity	immunity	NN
cord-312001-8p7scli8	55	7	was	be	VBD
cord-312001-8p7scli8	55	8	believed	believe	VBN
cord-312001-8p7scli8	55	9	to	to	TO
cord-312001-8p7scli8	55	10	be	be	VB
cord-312001-8p7scli8	55	11	exclusive	exclusive	JJ
cord-312001-8p7scli8	55	12	to	to	IN
cord-312001-8p7scli8	55	13	gnathostomes	gnathostome	NNS
cord-312001-8p7scli8	55	14	(	(	-LRB-
cord-312001-8p7scli8	55	15	jawed	jawed	JJ
cord-312001-8p7scli8	55	16	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	55	17	)	)	-RRB-
cord-312001-8p7scli8	55	18	.	.	.
cord-312001-8p7scli8	56	1	We	-PRON-	PRP
cord-312001-8p7scli8	56	2	now	now	RB
cord-312001-8p7scli8	56	3	know	know	VBP
cord-312001-8p7scli8	56	4	that	that	IN
cord-312001-8p7scli8	56	5	agnathans	agnathans	NNP
cord-312001-8p7scli8	56	6	(	(	-LRB-
cord-312001-8p7scli8	56	7	jawless	jawless	JJ
cord-312001-8p7scli8	56	8	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	56	9	)	)	-RRB-
cord-312001-8p7scli8	56	10	,	,	,
cord-312001-8p7scli8	56	11	including	include	VBG
cord-312001-8p7scli8	56	12	lampreys	lamprey	NNS
cord-312001-8p7scli8	56	13	and	and	CC
cord-312001-8p7scli8	56	14	hagfish	hagfish	NN
cord-312001-8p7scli8	56	15	,	,	,
cord-312001-8p7scli8	56	16	have	have	VBP
cord-312001-8p7scli8	56	17	also	also	RB
cord-312001-8p7scli8	56	18	evolved	evolve	VBN
cord-312001-8p7scli8	56	19	an	an	DT
cord-312001-8p7scli8	56	20	equivalent	equivalent	JJ
cord-312001-8p7scli8	56	21	adaptive	adaptive	JJ
cord-312001-8p7scli8	56	22	immune	immune	JJ
cord-312001-8p7scli8	56	23	system	system	NN
cord-312001-8p7scli8	56	24	with	with	IN
cord-312001-8p7scli8	56	25	specialized	specialized	JJ
cord-312001-8p7scli8	56	26	lymphocytes	lymphocyte	NNS
cord-312001-8p7scli8	56	27	termed	term	VBN
cord-312001-8p7scli8	56	28	,	,	,
cord-312001-8p7scli8	56	29	VLRA	VLRA	NNP
cord-312001-8p7scli8	56	30	,	,	,
cord-312001-8p7scli8	56	31	VLRB	VLRB	NNP
cord-312001-8p7scli8	56	32	and	and	CC
cord-312001-8p7scli8	56	33	VLRC	VLRC	NNP
cord-312001-8p7scli8	56	34	cells	cell	NNS
cord-312001-8p7scli8	56	35	,	,	,
cord-312001-8p7scli8	56	36	in	in	IN
cord-312001-8p7scli8	56	37	which	which	WDT
cord-312001-8p7scli8	56	38	specific	specific	JJ
cord-312001-8p7scli8	56	39	variable	variable	JJ
cord-312001-8p7scli8	56	40	lymphocyte	lymphocyte	NN
cord-312001-8p7scli8	56	41	receptors	receptor	NNS
cord-312001-8p7scli8	56	42	(	(	-LRB-
cord-312001-8p7scli8	56	43	VLRs	VLRs	NNP
cord-312001-8p7scli8	56	44	)	)	-RRB-
cord-312001-8p7scli8	56	45	are	be	VBP
cord-312001-8p7scli8	56	46	produced	produce	VBN
cord-312001-8p7scli8	56	47	through	through	IN
cord-312001-8p7scli8	56	48	somatic	somatic	JJ
cord-312001-8p7scli8	56	49	leucine	leucine	NN
cord-312001-8p7scli8	56	50	-	-	HYPH
cord-312001-8p7scli8	56	51	rich	rich	JJ
cord-312001-8p7scli8	56	52	repeat	repeat	NN
cord-312001-8p7scli8	56	53	(	(	-LRB-
cord-312001-8p7scli8	56	54	LRR	LRR	NNP
cord-312001-8p7scli8	56	55	)	)	-RRB-
cord-312001-8p7scli8	56	56	rearrangements	rearrangement	NNS
cord-312001-8p7scli8	56	57	[	[	-LRB-
cord-312001-8p7scli8	56	58	30	30	CD
cord-312001-8p7scli8	56	59	]	]	-RRB-
cord-312001-8p7scli8	56	60	.	.	.
cord-312001-8p7scli8	57	1	In	in	IN
cord-312001-8p7scli8	57	2	both	both	DT
cord-312001-8p7scli8	57	3	gnathostomes	gnathostome	NNS
cord-312001-8p7scli8	57	4	and	and	CC
cord-312001-8p7scli8	57	5	agnathans	agnathans	NNP
cord-312001-8p7scli8	57	6	,	,	,
cord-312001-8p7scli8	57	7	somatic	somatic	JJ
cord-312001-8p7scli8	57	8	recombination	recombination	NN
cord-312001-8p7scli8	57	9	events	event	NNS
cord-312001-8p7scli8	57	10	in	in	IN
cord-312001-8p7scli8	57	11	specialized	specialized	JJ
cord-312001-8p7scli8	57	12	cells	cell	NNS
cord-312001-8p7scli8	57	13	permitted	permit	VBD
cord-312001-8p7scli8	57	14	a	a	DT
cord-312001-8p7scli8	57	15	pathogen	pathogen	NN
cord-312001-8p7scli8	57	16	-	-	HYPH
cord-312001-8p7scli8	57	17	tailored	tailor	VBN
cord-312001-8p7scli8	57	18	response	response	NN
cord-312001-8p7scli8	57	19	and	and	CC
cord-312001-8p7scli8	57	20	endowed	endow	VBN
cord-312001-8p7scli8	57	21	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	57	22	species	specie	NNS
cord-312001-8p7scli8	57	23	with	with	IN
cord-312001-8p7scli8	57	24	an	an	DT
cord-312001-8p7scli8	57	25	immune	immune	JJ
cord-312001-8p7scli8	57	26	memory	memory	NN
cord-312001-8p7scli8	57	27	.	.	.
cord-312001-8p7scli8	58	1	Until	until	IN
cord-312001-8p7scli8	58	2	the	the	DT
cord-312001-8p7scli8	58	3	end	end	NN
cord-312001-8p7scli8	58	4	of	of	IN
cord-312001-8p7scli8	58	5	the	the	DT
cord-312001-8p7scli8	58	6	last	last	JJ
cord-312001-8p7scli8	58	7	century	century	NN
cord-312001-8p7scli8	58	8	,	,	,
cord-312001-8p7scli8	58	9	most	most	JJS
cord-312001-8p7scli8	58	10	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	58	11	immunologists	immunologist	NNS
cord-312001-8p7scli8	58	12	concentrated	concentrate	VBD
cord-312001-8p7scli8	58	13	their	-PRON-	PRP$
cord-312001-8p7scli8	58	14	efforts	effort	NNS
cord-312001-8p7scli8	58	15	on	on	IN
cord-312001-8p7scli8	58	16	studying	study	VBG
cord-312001-8p7scli8	58	17	the	the	DT
cord-312001-8p7scli8	58	18	adaptive	adaptive	JJ
cord-312001-8p7scli8	58	19	arm	arm	NN
cord-312001-8p7scli8	58	20	of	of	IN
cord-312001-8p7scli8	58	21	the	the	DT
cord-312001-8p7scli8	58	22	immune	immune	JJ
cord-312001-8p7scli8	58	23	system	system	NN
cord-312001-8p7scli8	58	24	.	.	.
cord-312001-8p7scli8	59	1	Nearly	nearly	RB
cord-312001-8p7scli8	59	2	30	30	CD
cord-312001-8p7scli8	59	3	years	year	NNS
cord-312001-8p7scli8	59	4	ago	ago	RB
cord-312001-8p7scli8	59	5	,	,	,
cord-312001-8p7scli8	59	6	Charles	Charles	NNP
cord-312001-8p7scli8	59	7	Janeway	Janeway	NNP
cord-312001-8p7scli8	59	8	predicted	predict	VBD
cord-312001-8p7scli8	59	9	the	the	DT
cord-312001-8p7scli8	59	10	presence	presence	NN
cord-312001-8p7scli8	59	11	of	of	IN
cord-312001-8p7scli8	59	12	an	an	DT
cord-312001-8p7scli8	59	13	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	59	14	ancient	ancient	JJ
cord-312001-8p7scli8	59	15	immune	immune	JJ
cord-312001-8p7scli8	59	16	system	system	NN
cord-312001-8p7scli8	59	17	that	that	WDT
cord-312001-8p7scli8	59	18	detects	detect	VBZ
cord-312001-8p7scli8	59	19	conserved	conserve	VBN
cord-312001-8p7scli8	59	20	microbial	microbial	NN
cord-312001-8p7scli8	59	21	and	and	CC
cord-312001-8p7scli8	59	22	danger	danger	NN
cord-312001-8p7scli8	59	23	signals	signal	NNS
cord-312001-8p7scli8	59	24	,	,	,
cord-312001-8p7scli8	59	25	termed	term	VBD
cord-312001-8p7scli8	59	26	the	the	DT
cord-312001-8p7scli8	59	27	pathogen	pathogen	NN
cord-312001-8p7scli8	59	28	-	-	HYPH
cord-312001-8p7scli8	59	29	associated	associate	VBN
cord-312001-8p7scli8	59	30	molecular	molecular	JJ
cord-312001-8p7scli8	59	31	patterns	pattern	NNS
cord-312001-8p7scli8	59	32	(	(	-LRB-
cord-312001-8p7scli8	59	33	PAMPs	pamp	NNS
cord-312001-8p7scli8	59	34	)	)	-RRB-
cord-312001-8p7scli8	59	35	and	and	CC
cord-312001-8p7scli8	59	36	danger	danger	NN
cord-312001-8p7scli8	59	37	-	-	HYPH
cord-312001-8p7scli8	59	38	associated	associate	VBN
cord-312001-8p7scli8	59	39	molecular	molecular	JJ
cord-312001-8p7scli8	59	40	patterns	pattern	NNS
cord-312001-8p7scli8	59	41	(	(	-LRB-
cord-312001-8p7scli8	59	42	DAMPs	damp	NNS
cord-312001-8p7scli8	59	43	)	)	-RRB-
cord-312001-8p7scli8	59	44	,	,	,
cord-312001-8p7scli8	59	45	respectively	respectively	RB
cord-312001-8p7scli8	59	46	.	.	.
cord-312001-8p7scli8	60	1	Janeway	Janeway	NNP
cord-312001-8p7scli8	60	2	predicted	predict	VBD
cord-312001-8p7scli8	60	3	that	that	IN
cord-312001-8p7scli8	60	4	this	this	DT
cord-312001-8p7scli8	60	5	innate	innate	JJ
cord-312001-8p7scli8	60	6	immune	immune	JJ
cord-312001-8p7scli8	60	7	system	system	NN
cord-312001-8p7scli8	60	8	precedes	precede	VBZ
cord-312001-8p7scli8	60	9	and	and	CC
cord-312001-8p7scli8	60	10	instructs	instruct	VBZ
cord-312001-8p7scli8	60	11	the	the	DT
cord-312001-8p7scli8	60	12	adaptive	adaptive	JJ
cord-312001-8p7scli8	60	13	system	system	NN
cord-312001-8p7scli8	60	14	[	[	-LRB-
cord-312001-8p7scli8	60	15	31	31	CD
cord-312001-8p7scli8	60	16	,	,	,
cord-312001-8p7scli8	60	17	32	32	CD
cord-312001-8p7scli8	60	18	]	]	-RRB-
cord-312001-8p7scli8	60	19	and	and	CC
cord-312001-8p7scli8	60	20	posited	posit	VBD
cord-312001-8p7scli8	60	21	that	that	IN
cord-312001-8p7scli8	60	22	PAMPs	pamp	NNS
cord-312001-8p7scli8	60	23	and	and	CC
cord-312001-8p7scli8	60	24	DAMPs	damp	NNS
cord-312001-8p7scli8	60	25	must	must	MD
cord-312001-8p7scli8	60	26	be	be	VB
cord-312001-8p7scli8	60	27	sensed	sense	VBN
cord-312001-8p7scli8	60	28	by	by	IN
cord-312001-8p7scli8	60	29	germ	germ	NN
cord-312001-8p7scli8	60	30	-	-	HYPH
cord-312001-8p7scli8	60	31	line	line	NN
cord-312001-8p7scli8	60	32	encoded	encode	VBN
cord-312001-8p7scli8	60	33	PRRs	prr	NNS
cord-312001-8p7scli8	60	34	.	.	.
cord-312001-8p7scli8	61	1	At	at	IN
cord-312001-8p7scli8	61	2	that	that	DT
cord-312001-8p7scli8	61	3	time	time	NN
cord-312001-8p7scli8	61	4	,	,	,
cord-312001-8p7scli8	61	5	the	the	DT
cord-312001-8p7scli8	61	6	innate	innate	JJ
cord-312001-8p7scli8	61	7	immune	immune	JJ
cord-312001-8p7scli8	61	8	components	component	NNS
cord-312001-8p7scli8	61	9	were	be	VBD
cord-312001-8p7scli8	61	10	severely	severely	RB
cord-312001-8p7scli8	61	11	understudied	understudied	JJ
cord-312001-8p7scli8	61	12	and	and	CC
cord-312001-8p7scli8	61	13	TLRs	tlr	NNS
cord-312001-8p7scli8	61	14	,	,	,
cord-312001-8p7scli8	61	15	RLRs	rlr	NNS
cord-312001-8p7scli8	61	16	and	and	CC
cord-312001-8p7scli8	61	17	STING	STING	NNP
cord-312001-8p7scli8	61	18	's	's	POS
cord-312001-8p7scli8	61	19	respective	respective	JJ
cord-312001-8p7scli8	61	20	functions	function	NNS
cord-312001-8p7scli8	61	21	in	in	IN
cord-312001-8p7scli8	61	22	immunity	immunity	NN
cord-312001-8p7scli8	61	23	were	be	VBD
cord-312001-8p7scli8	61	24	completely	completely	RB
cord-312001-8p7scli8	61	25	unknown	unknown	JJ
cord-312001-8p7scli8	61	26	.	.	.
cord-312001-8p7scli8	62	1	This	this	DT
cord-312001-8p7scli8	62	2	illustrates	illustrate	VBZ
cord-312001-8p7scli8	62	3	the	the	DT
cord-312001-8p7scli8	62	4	immense	immense	JJ
cord-312001-8p7scli8	62	5	leap	leap	NN
cord-312001-8p7scli8	62	6	forward	forward	IN
cord-312001-8p7scli8	62	7	the	the	DT
cord-312001-8p7scli8	62	8	innate	innate	JJ
cord-312001-8p7scli8	62	9	immunity	immunity	NN
cord-312001-8p7scli8	62	10	field	field	NN
cord-312001-8p7scli8	62	11	has	have	VBZ
cord-312001-8p7scli8	62	12	experienced	experience	VBN
cord-312001-8p7scli8	62	13	in	in	IN
cord-312001-8p7scli8	62	14	the	the	DT
cord-312001-8p7scli8	62	15	last	last	JJ
cord-312001-8p7scli8	62	16	three	three	CD
cord-312001-8p7scli8	62	17	decades	decade	NNS
cord-312001-8p7scli8	62	18	.	.	.
cord-312001-8p7scli8	63	1	Today	today	NN
cord-312001-8p7scli8	63	2	,	,	,
cord-312001-8p7scli8	63	3	we	-PRON-	PRP
cord-312001-8p7scli8	63	4	know	know	VBP
cord-312001-8p7scli8	63	5	that	that	IN
cord-312001-8p7scli8	63	6	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	63	7	share	share	VBP
cord-312001-8p7scli8	63	8	with	with	IN
cord-312001-8p7scli8	63	9	other	other	JJ
cord-312001-8p7scli8	63	10	invertebrate	invertebrate	JJ
cord-312001-8p7scli8	63	11	animals	animal	NNS
cord-312001-8p7scli8	63	12	specialized	specialize	VBN
cord-312001-8p7scli8	63	13	phagocytic	phagocytic	JJ
cord-312001-8p7scli8	63	14	cells	cell	NNS
cord-312001-8p7scli8	63	15	that	that	WDT
cord-312001-8p7scli8	63	16	are	be	VBP
cord-312001-8p7scli8	63	17	able	able	JJ
cord-312001-8p7scli8	63	18	to	to	TO
cord-312001-8p7scli8	63	19	discriminate	discriminate	VB
cord-312001-8p7scli8	63	20	between	between	IN
cord-312001-8p7scli8	63	21	self	self	NN
cord-312001-8p7scli8	63	22	and	and	CC
cord-312001-8p7scli8	63	23	non	non	JJ
cord-312001-8p7scli8	63	24	-	-	JJ
cord-312001-8p7scli8	63	25	self	self	JJ
cord-312001-8p7scli8	63	26	.	.	.
cord-312001-8p7scli8	64	1	By	by	IN
cord-312001-8p7scli8	64	2	recognizing	recognize	VBG
cord-312001-8p7scli8	64	3	general	general	JJ
cord-312001-8p7scli8	64	4	pathogen	pathogen	NN
cord-312001-8p7scli8	64	5	molecular	molecular	JJ
cord-312001-8p7scli8	64	6	patterns	pattern	NNS
cord-312001-8p7scli8	64	7	(	(	-LRB-
cord-312001-8p7scli8	64	8	PAMPs	pamp	NNS
cord-312001-8p7scli8	64	9	,	,	,
cord-312001-8p7scli8	64	10	e.g.	e.g.	RB
cord-312001-8p7scli8	64	11	,	,	,
cord-312001-8p7scli8	64	12	viral	viral	JJ
cord-312001-8p7scli8	64	13	double	double	RB
cord-312001-8p7scli8	64	14	-	-	HYPH
cord-312001-8p7scli8	64	15	stranded	strand	VBN
cord-312001-8p7scli8	64	16	RNA	RNA	NNP
cord-312001-8p7scli8	64	17	)	)	-RRB-
cord-312001-8p7scli8	64	18	and	and	CC
cord-312001-8p7scli8	64	19	danger	danger	NN
cord-312001-8p7scli8	64	20	signals	signal	NNS
cord-312001-8p7scli8	64	21	(	(	-LRB-
cord-312001-8p7scli8	64	22	DAMPs	damp	NNS
cord-312001-8p7scli8	64	23	)	)	-RRB-
cord-312001-8p7scli8	64	24	,	,	,
cord-312001-8p7scli8	64	25	these	these	DT
cord-312001-8p7scli8	64	26	cells	cell	NNS
cord-312001-8p7scli8	64	27	establish	establish	VBP
cord-312001-8p7scli8	64	28	an	an	DT
cord-312001-8p7scli8	64	29	immediate	immediate	JJ
cord-312001-8p7scli8	64	30	and	and	CC
cord-312001-8p7scli8	64	31	general	general	JJ
cord-312001-8p7scli8	64	32	inflammatory	inflammatory	JJ
cord-312001-8p7scli8	64	33	response	response	NN
cord-312001-8p7scli8	64	34	translated	translate	VBN
cord-312001-8p7scli8	64	35	into	into	IN
cord-312001-8p7scli8	64	36	an	an	DT
cord-312001-8p7scli8	64	37	antimicrobial	antimicrobial	JJ
cord-312001-8p7scli8	64	38	and/or	and/or	CC
cord-312001-8p7scli8	64	39	antiviral	antiviral	JJ
cord-312001-8p7scli8	64	40	state	state	NN
cord-312001-8p7scli8	64	41	.	.	.
cord-312001-8p7scli8	65	1	Although	although	IN
cord-312001-8p7scli8	65	2	mainly	mainly	RB
cord-312001-8p7scli8	65	3	studied	study	VBN
cord-312001-8p7scli8	65	4	in	in	IN
cord-312001-8p7scli8	65	5	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	65	6	,	,	,
cord-312001-8p7scli8	65	7	the	the	DT
cord-312001-8p7scli8	65	8	machineries	machinery	NNS
cord-312001-8p7scli8	65	9	responsible	responsible	JJ
cord-312001-8p7scli8	65	10	for	for	IN
cord-312001-8p7scli8	65	11	these	these	DT
cord-312001-8p7scli8	65	12	responses	response	NNS
cord-312001-8p7scli8	65	13	transcend	transcend	VBP
cord-312001-8p7scli8	65	14	this	this	DT
cord-312001-8p7scli8	65	15	group	group	NN
cord-312001-8p7scli8	65	16	and	and	CC
cord-312001-8p7scli8	65	17	are	be	VBP
cord-312001-8p7scli8	65	18	fairly	fairly	RB
cord-312001-8p7scli8	65	19	conserved	conserve	VBN
cord-312001-8p7scli8	65	20	in	in	IN
cord-312001-8p7scli8	65	21	all	all	DT
cord-312001-8p7scli8	65	22	animals	animal	NNS
cord-312001-8p7scli8	65	23	.	.	.
cord-312001-8p7scli8	66	1	We	-PRON-	PRP
cord-312001-8p7scli8	66	2	will	will	MD
cord-312001-8p7scli8	66	3	describe	describe	VB
cord-312001-8p7scli8	66	4	a	a	DT
cord-312001-8p7scli8	66	5	particular	particular	JJ
cord-312001-8p7scli8	66	6	arm	arm	NN
cord-312001-8p7scli8	66	7	of	of	IN
cord-312001-8p7scli8	66	8	the	the	DT
cord-312001-8p7scli8	66	9	innate	innate	JJ
cord-312001-8p7scli8	66	10	immune	immune	JJ
cord-312001-8p7scli8	66	11	pathways	pathway	NNS
cord-312001-8p7scli8	66	12	,	,	,
cord-312001-8p7scli8	66	13	the	the	DT
cord-312001-8p7scli8	66	14	innate	innate	JJ
cord-312001-8p7scli8	66	15	antiviral	antiviral	JJ
cord-312001-8p7scli8	66	16	system	system	NN
cord-312001-8p7scli8	66	17	that	that	WDT
cord-312001-8p7scli8	66	18	is	be	VBZ
cord-312001-8p7scli8	66	19	best	well	RBS
cord-312001-8p7scli8	66	20	studied	study	VBN
cord-312001-8p7scli8	66	21	in	in	IN
cord-312001-8p7scli8	66	22	mammals	mammal	NNS
cord-312001-8p7scli8	66	23	.	.	.
cord-312001-8p7scli8	67	1	Unlike	unlike	IN
cord-312001-8p7scli8	67	2	bacteria	bacteria	NNS
cord-312001-8p7scli8	67	3	,	,	,
cord-312001-8p7scli8	67	4	viruses	virus	NNS
cord-312001-8p7scli8	67	5	represent	represent	VBP
cord-312001-8p7scli8	67	6	a	a	DT
cord-312001-8p7scli8	67	7	unique	unique	JJ
cord-312001-8p7scli8	67	8	challenge	challenge	NN
cord-312001-8p7scli8	67	9	for	for	IN
cord-312001-8p7scli8	67	10	PRRs	prr	NNS
cord-312001-8p7scli8	67	11	because	because	IN
cord-312001-8p7scli8	67	12	they	-PRON-	PRP
cord-312001-8p7scli8	67	13	possess	possess	VBP
cord-312001-8p7scli8	67	14	few	few	JJ
cord-312001-8p7scli8	67	15	unique	unique	JJ
cord-312001-8p7scli8	67	16	signatures	signature	NNS
cord-312001-8p7scli8	67	17	that	that	WDT
cord-312001-8p7scli8	67	18	could	could	MD
cord-312001-8p7scli8	67	19	serve	serve	VB
cord-312001-8p7scli8	67	20	as	as	IN
cord-312001-8p7scli8	67	21	PAMPs	pamp	NNS
cord-312001-8p7scli8	67	22	[	[	-LRB-
cord-312001-8p7scli8	67	23	33	33	CD
cord-312001-8p7scli8	67	24	]	]	-RRB-
cord-312001-8p7scli8	67	25	.	.	.
cord-312001-8p7scli8	68	1	However	however	RB
cord-312001-8p7scli8	68	2	,	,	,
cord-312001-8p7scli8	68	3	viral	viral	JJ
cord-312001-8p7scli8	68	4	nucleic	nucleic	JJ
cord-312001-8p7scli8	68	5	acids	acid	NNS
cord-312001-8p7scli8	68	6	(	(	-LRB-
cord-312001-8p7scli8	68	7	DNA	DNA	NNP
cord-312001-8p7scli8	68	8	or	or	CC
cord-312001-8p7scli8	68	9	RNA	RNA	NNP
cord-312001-8p7scli8	68	10	)	)	-RRB-
cord-312001-8p7scli8	68	11	could	could	MD
cord-312001-8p7scli8	68	12	have	have	VB
cord-312001-8p7scli8	68	13	peculiar	peculiar	JJ
cord-312001-8p7scli8	68	14	biochemical	biochemical	JJ
cord-312001-8p7scli8	68	15	features	feature	NNS
cord-312001-8p7scli8	68	16	that	that	WDT
cord-312001-8p7scli8	68	17	differentiate	differentiate	VBP
cord-312001-8p7scli8	68	18	them	-PRON-	PRP
cord-312001-8p7scli8	68	19	from	from	IN
cord-312001-8p7scli8	68	20	endogenous	endogenous	JJ
cord-312001-8p7scli8	68	21	host	host	NN
cord-312001-8p7scli8	68	22	RNA	RNA	NNP
cord-312001-8p7scli8	68	23	[	[	-LRB-
cord-312001-8p7scli8	68	24	34	34	CD
cord-312001-8p7scli8	68	25	]	]	-RRB-
cord-312001-8p7scli8	68	26	.	.	.
cord-312001-8p7scli8	69	1	In	in	IN
cord-312001-8p7scli8	69	2	RNA	RNA	NNP
cord-312001-8p7scli8	69	3	molecules	molecule	NNS
cord-312001-8p7scli8	69	4	,	,	,
cord-312001-8p7scli8	69	5	for	for	IN
cord-312001-8p7scli8	69	6	example	example	NN
cord-312001-8p7scli8	69	7	,	,	,
cord-312001-8p7scli8	69	8	the	the	DT
cord-312001-8p7scli8	69	9	lack	lack	NN
cord-312001-8p7scli8	69	10	of	of	IN
cord-312001-8p7scli8	69	11	a	a	DT
cord-312001-8p7scli8	69	12	7-methylguanosine	7-methylguanosine	CD
cord-312001-8p7scli8	69	13	cap	cap	NN
cord-312001-8p7scli8	69	14	structure	structure	NN
cord-312001-8p7scli8	69	15	,	,	,
cord-312001-8p7scli8	69	16	double	double	JJ
cord-312001-8p7scli8	69	17	strandedness	strandedness	NN
cord-312001-8p7scli8	69	18	or	or	CC
cord-312001-8p7scli8	69	19	the	the	DT
cord-312001-8p7scli8	69	20	trior	trior	JJ
cord-312001-8p7scli8	69	21	bi	bi	NN
cord-312001-8p7scli8	69	22	-	-	NN
cord-312001-8p7scli8	69	23	phosphorylation	phosphorylation	JJ
cord-312001-8p7scli8	69	24	at	at	IN
cord-312001-8p7scli8	69	25	their	-PRON-	PRP$
cord-312001-8p7scli8	69	26	ends	end	NNS
cord-312001-8p7scli8	69	27	are	be	VBP
cord-312001-8p7scli8	69	28	often	often	RB
cord-312001-8p7scli8	69	29	used	use	VBN
cord-312001-8p7scli8	69	30	by	by	IN
cord-312001-8p7scli8	69	31	PRRs	prr	NNS
cord-312001-8p7scli8	69	32	for	for	IN
cord-312001-8p7scli8	69	33	self	self	NN
cord-312001-8p7scli8	69	34	/	/	SYM
cord-312001-8p7scli8	69	35	non	non	JJ
cord-312001-8p7scli8	69	36	-	-	JJ
cord-312001-8p7scli8	69	37	self	self	JJ
cord-312001-8p7scli8	69	38	-	-	HYPH
cord-312001-8p7scli8	69	39	discrimination	discrimination	NN
cord-312001-8p7scli8	69	40	.	.	.
cord-312001-8p7scli8	70	1	PRRs	prr	NNS
cord-312001-8p7scli8	70	2	that	that	WDT
cord-312001-8p7scli8	70	3	detect	detect	VBP
cord-312001-8p7scli8	70	4	viral	viral	JJ
cord-312001-8p7scli8	70	5	infection	infection	NN
cord-312001-8p7scli8	70	6	can	can	MD
cord-312001-8p7scli8	70	7	be	be	VB
cord-312001-8p7scli8	70	8	classified	classify	VBN
cord-312001-8p7scli8	70	9	into	into	IN
cord-312001-8p7scli8	70	10	four	four	CD
cord-312001-8p7scli8	70	11	families	family	NNS
cord-312001-8p7scli8	70	12	:	:	:
cord-312001-8p7scli8	70	13	TLRs	TLRs	NNP
cord-312001-8p7scli8	70	14	,	,	,
cord-312001-8p7scli8	70	15	RLRs	RLRs	NNP
cord-312001-8p7scli8	70	16	,	,	,
cord-312001-8p7scli8	70	17	AIM2-like	aim2-like	IN
cord-312001-8p7scli8	70	18	receptors	receptor	NNS
cord-312001-8p7scli8	70	19	(	(	-LRB-
cord-312001-8p7scli8	70	20	ALRs	alr	NNS
cord-312001-8p7scli8	70	21	)	)	-RRB-
cord-312001-8p7scli8	70	22	and	and	CC
cord-312001-8p7scli8	70	23	the	the	DT
cord-312001-8p7scli8	70	24	cGAS	cgas	JJ
cord-312001-8p7scli8	70	25	-	-	HYPH
cord-312001-8p7scli8	70	26	STING	sting	NN
cord-312001-8p7scli8	70	27	sensors	sensor	NNS
cord-312001-8p7scli8	70	28	[	[	-LRB-
cord-312001-8p7scli8	70	29	35	35	CD
cord-312001-8p7scli8	70	30	]	]	-RRB-
cord-312001-8p7scli8	70	31	.	.	.
cord-312001-8p7scli8	71	1	After	after	IN
cord-312001-8p7scli8	71	2	viral	viral	JJ
cord-312001-8p7scli8	71	3	detection	detection	NN
cord-312001-8p7scli8	71	4	,	,	,
cord-312001-8p7scli8	71	5	PRR	PRR	NNP
cord-312001-8p7scli8	71	6	-	-	HYPH
cord-312001-8p7scli8	71	7	mediated	mediate	VBN
cord-312001-8p7scli8	71	8	signaling	signal	VBG
cord-312001-8p7scli8	71	9	directly	directly	RB
cord-312001-8p7scli8	71	10	or	or	CC
cord-312001-8p7scli8	71	11	indirectly	indirectly	RB
cord-312001-8p7scli8	71	12	induces	induce	VBZ
cord-312001-8p7scli8	71	13	transcription	transcription	NN
cord-312001-8p7scli8	71	14	factors	factor	NNS
cord-312001-8p7scli8	71	15	,	,	,
cord-312001-8p7scli8	71	16	including	include	VBG
cord-312001-8p7scli8	71	17	IFN	IFN	NNP
cord-312001-8p7scli8	71	18	-	-	HYPH
cord-312001-8p7scli8	71	19	regulatory	regulatory	JJ
cord-312001-8p7scli8	71	20	factors	factor	NNS
cord-312001-8p7scli8	71	21	(	(	-LRB-
cord-312001-8p7scli8	71	22	IRFs	IRFs	NNP
cord-312001-8p7scli8	71	23	)	)	-RRB-
cord-312001-8p7scli8	71	24	and	and	CC
cord-312001-8p7scli8	71	25	nuclear	nuclear	JJ
cord-312001-8p7scli8	71	26	factor	factor	NN
cord-312001-8p7scli8	71	27	k	k	NNP
cord-312001-8p7scli8	71	28	-	-	HYPH
cord-312001-8p7scli8	71	29	B	B	NNP
cord-312001-8p7scli8	72	1	(	(	-LRB-
cord-312001-8p7scli8	72	2	NF	NF	NNP
cord-312001-8p7scli8	72	3	-	-	HYPH
cord-312001-8p7scli8	72	4	kB	kB	NNP
cord-312001-8p7scli8	72	5	)	)	-RRB-
cord-312001-8p7scli8	73	1	to	to	TO
cord-312001-8p7scli8	73	2	upregulate	upregulate	VB
cord-312001-8p7scli8	73	3	expression	expression	NN
cord-312001-8p7scli8	73	4	of	of	IN
cord-312001-8p7scli8	73	5	VSGs	vsg	NNS
cord-312001-8p7scli8	73	6	including	include	VBG
cord-312001-8p7scli8	73	7	pro	pro	JJ
cord-312001-8p7scli8	73	8	-	-	JJ
cord-312001-8p7scli8	73	9	inflammatory	inflammatory	JJ
cord-312001-8p7scli8	73	10	cytokines	cytokine	NNS
cord-312001-8p7scli8	73	11	.	.	.
cord-312001-8p7scli8	74	1	Another	another	DT
cord-312001-8p7scli8	74	2	class	class	NN
cord-312001-8p7scli8	74	3	of	of	IN
cord-312001-8p7scli8	74	4	PRRs	prr	NNS
cord-312001-8p7scli8	74	5	such	such	JJ
cord-312001-8p7scli8	74	6	as	as	IN
cord-312001-8p7scli8	74	7	double	double	RB
cord-312001-8p7scli8	74	8	-	-	HYPH
cord-312001-8p7scli8	74	9	stranded	strand	VBN
cord-312001-8p7scli8	74	10	RNA	RNA	NNP
cord-312001-8p7scli8	74	11	(	(	-LRB-
cord-312001-8p7scli8	74	12	dsRNA	dsrna	NN
cord-312001-8p7scli8	74	13	)	)	-RRB-
cord-312001-8p7scli8	74	14	activated	activate	VBN
cord-312001-8p7scli8	74	15	protein	protein	NN
cord-312001-8p7scli8	74	16	kinase	kinase	NN
cord-312001-8p7scli8	74	17	R	r	NN
cord-312001-8p7scli8	74	18	(	(	-LRB-
cord-312001-8p7scli8	74	19	PKR	PKR	NNP
cord-312001-8p7scli8	74	20	;	;	:
cord-312001-8p7scli8	74	21	also	also	RB
cord-312001-8p7scli8	74	22	known	know	VBN
cord-312001-8p7scli8	74	23	as	as	IN
cord-312001-8p7scli8	74	24	eIF2AK2	eIF2AK2	NNP
cord-312001-8p7scli8	74	25	)	)	-RRB-
cord-312001-8p7scli8	74	26	,	,	,
cord-312001-8p7scli8	74	27	adenosine	adenosine	NN
cord-312001-8p7scli8	74	28	deaminase	deaminase	NN
cord-312001-8p7scli8	74	29	acting	act	VBG
cord-312001-8p7scli8	74	30	on	on	IN
cord-312001-8p7scli8	74	31	RNA	RNA	NNP
cord-312001-8p7scli8	74	32	1	1	CD
cord-312001-8p7scli8	74	33	(	(	-LRB-
cord-312001-8p7scli8	74	34	ADAR1	ADAR1	NNP
cord-312001-8p7scli8	74	35	)	)	-RRB-
cord-312001-8p7scli8	74	36	and	and	CC
cord-312001-8p7scli8	74	37	2	2	CD
cord-312001-8p7scli8	74	38	-5	-5	CD
cord-312001-8p7scli8	74	39	-oligoadenylate	-oligoadenylate	HYPH
cord-312001-8p7scli8	74	40	synthetase	synthetase	NN
cord-312001-8p7scli8	74	41	1	1	CD
cord-312001-8p7scli8	74	42	(	(	-LRB-
cord-312001-8p7scli8	74	43	OAS1	OAS1	NNP
cord-312001-8p7scli8	74	44	)	)	-RRB-
cord-312001-8p7scli8	74	45	also	also	RB
cord-312001-8p7scli8	74	46	contribute	contribute	VBP
cord-312001-8p7scli8	74	47	to	to	IN
cord-312001-8p7scli8	74	48	innate	innate	JJ
cord-312001-8p7scli8	74	49	immunity	immunity	NN
cord-312001-8p7scli8	74	50	[	[	-LRB-
cord-312001-8p7scli8	74	51	34	34	CD
cord-312001-8p7scli8	74	52	]	]	-RRB-
cord-312001-8p7scli8	74	53	.	.	.
cord-312001-8p7scli8	75	1	These	these	DT
cord-312001-8p7scli8	75	2	also	also	RB
cord-312001-8p7scli8	75	3	recognize	recognize	VBP
cord-312001-8p7scli8	75	4	viral	viral	JJ
cord-312001-8p7scli8	75	5	signatures	signature	NNS
cord-312001-8p7scli8	75	6	;	;	:
cord-312001-8p7scli8	75	7	however	however	RB
cord-312001-8p7scli8	75	8	,	,	,
cord-312001-8p7scli8	75	9	their	-PRON-	PRP$
cord-312001-8p7scli8	75	10	main	main	JJ
cord-312001-8p7scli8	75	11	function	function	NN
cord-312001-8p7scli8	75	12	is	be	VBZ
cord-312001-8p7scli8	75	13	not	not	RB
cord-312001-8p7scli8	75	14	necessarily	necessarily	RB
cord-312001-8p7scli8	75	15	to	to	TO
cord-312001-8p7scli8	75	16	induce	induce	VB
cord-312001-8p7scli8	75	17	a	a	DT
cord-312001-8p7scli8	75	18	transcriptional	transcriptional	JJ
cord-312001-8p7scli8	75	19	immune	immune	JJ
cord-312001-8p7scli8	75	20	response	response	NN
cord-312001-8p7scli8	75	21	,	,	,
cord-312001-8p7scli8	75	22	but	but	CC
cord-312001-8p7scli8	75	23	rather	rather	RB
cord-312001-8p7scli8	75	24	to	to	TO
cord-312001-8p7scli8	75	25	directly	directly	RB
cord-312001-8p7scli8	75	26	attack	attack	VB
cord-312001-8p7scli8	75	27	viral	viral	JJ
cord-312001-8p7scli8	75	28	RNA	rna	NN
cord-312001-8p7scli8	75	29	by	by	IN
cord-312001-8p7scli8	75	30	degrading	degrade	VBG
cord-312001-8p7scli8	75	31	it	-PRON-	PRP
cord-312001-8p7scli8	75	32	or	or	CC
cord-312001-8p7scli8	75	33	inhibiting	inhibit	VBG
cord-312001-8p7scli8	75	34	its	-PRON-	PRP$
cord-312001-8p7scli8	75	35	translation	translation	NN
cord-312001-8p7scli8	75	36	.	.	.
cord-312001-8p7scli8	76	1	For	for	IN
cord-312001-8p7scli8	76	2	this	this	DT
cord-312001-8p7scli8	76	3	reason	reason	NN
cord-312001-8p7scli8	76	4	,	,	,
cord-312001-8p7scli8	76	5	these	these	DT
cord-312001-8p7scli8	76	6	are	be	VBP
cord-312001-8p7scli8	76	7	not	not	RB
cord-312001-8p7scli8	76	8	usually	usually	RB
cord-312001-8p7scli8	76	9	considered	consider	VBN
cord-312001-8p7scli8	76	10	receptors	receptor	NNS
cord-312001-8p7scli8	76	11	.	.	.
cord-312001-8p7scli8	77	1	Viruses	virus	NNS
cord-312001-8p7scli8	77	2	are	be	VBP
cord-312001-8p7scli8	77	3	obligatory	obligatory	JJ
cord-312001-8p7scli8	77	4	intracellular	intracellular	JJ
cord-312001-8p7scli8	77	5	parasites	parasite	NNS
cord-312001-8p7scli8	77	6	,	,	,
cord-312001-8p7scli8	77	7	therefore	therefore	RB
cord-312001-8p7scli8	77	8	their	-PRON-	PRP$
cord-312001-8p7scli8	77	9	detection	detection	NN
cord-312001-8p7scli8	77	10	by	by	IN
cord-312001-8p7scli8	77	11	PRRs	prr	NNS
cord-312001-8p7scli8	77	12	most	most	RBS
cord-312001-8p7scli8	77	13	often	often	RB
cord-312001-8p7scli8	77	14	occurs	occur	VBZ
cord-312001-8p7scli8	77	15	in	in	IN
cord-312001-8p7scli8	77	16	the	the	DT
cord-312001-8p7scli8	77	17	intracellular	intracellular	JJ
cord-312001-8p7scli8	77	18	milieu	milieu	NN
cord-312001-8p7scli8	77	19	.	.	.
cord-312001-8p7scli8	78	1	Endosomal	Endosomal	NNP
cord-312001-8p7scli8	78	2	transmembrane	transmembrane	NN
cord-312001-8p7scli8	78	3	TLRs	tlr	NNS
cord-312001-8p7scli8	78	4	,	,	,
cord-312001-8p7scli8	78	5	including	include	VBG
cord-312001-8p7scli8	78	6	TLR3	TLR3	NNP
cord-312001-8p7scli8	78	7	,	,	,
cord-312001-8p7scli8	78	8	TLR7	TLR7	NNP
cord-312001-8p7scli8	78	9	and	and	CC
cord-312001-8p7scli8	78	10	TLR8	TLR8	NNP
cord-312001-8p7scli8	78	11	recognize	recognize	VB
cord-312001-8p7scli8	78	12	dsRNA	dsrna	NN
cord-312001-8p7scli8	78	13	in	in	IN
cord-312001-8p7scli8	78	14	the	the	DT
cord-312001-8p7scli8	78	15	endosome	endosome	NN
cord-312001-8p7scli8	78	16	lumen	lumen	NN
cord-312001-8p7scli8	78	17	[	[	-LRB-
cord-312001-8p7scli8	78	18	36	36	CD
cord-312001-8p7scli8	78	19	]	]	-RRB-
cord-312001-8p7scli8	79	1	[	[	-LRB-
cord-312001-8p7scli8	79	2	37	37	CD
cord-312001-8p7scli8	79	3	]	]	-RRB-
cord-312001-8p7scli8	79	4	[	[	-LRB-
cord-312001-8p7scli8	79	5	38	38	CD
cord-312001-8p7scli8	79	6	]	]	-RRB-
cord-312001-8p7scli8	79	7	.	.	.
cord-312001-8p7scli8	80	1	RLRs	RLRs	NNP
cord-312001-8p7scli8	80	2	including	include	VBG
cord-312001-8p7scli8	80	3	RIG-	RIG-	NNP
cord-312001-8p7scli8	81	1	I	-PRON-	PRP
cord-312001-8p7scli8	81	2	[	[	-LRB-
cord-312001-8p7scli8	81	3	39	39	CD
cord-312001-8p7scli8	81	4	]	]	-RRB-
cord-312001-8p7scli8	81	5	,	,	,
cord-312001-8p7scli8	81	6	melanoma	melanoma	NN
cord-312001-8p7scli8	81	7	differentiation	differentiation	NN
cord-312001-8p7scli8	81	8	associated	associate	VBD
cord-312001-8p7scli8	81	9	gene	gene	NN
cord-312001-8p7scli8	81	10	5	5	CD
cord-312001-8p7scli8	81	11	(	(	-LRB-
cord-312001-8p7scli8	81	12	MDA5	MDA5	NNP
cord-312001-8p7scli8	81	13	)	)	-RRB-
cord-312001-8p7scli8	81	14	[	[	-LRB-
cord-312001-8p7scli8	81	15	40	40	CD
cord-312001-8p7scli8	81	16	]	]	-RRB-
cord-312001-8p7scli8	81	17	,	,	,
cord-312001-8p7scli8	81	18	and	and	CC
cord-312001-8p7scli8	81	19	laboratory	laboratory	NN
cord-312001-8p7scli8	81	20	of	of	IN
cord-312001-8p7scli8	81	21	genetics	genetic	NNS
cord-312001-8p7scli8	81	22	and	and	CC
cord-312001-8p7scli8	81	23	physiology	physiology	NN
cord-312001-8p7scli8	81	24	2	2	CD
cord-312001-8p7scli8	81	25	(	(	-LRB-
cord-312001-8p7scli8	81	26	LGP2	LGP2	NNP
cord-312001-8p7scli8	81	27	)	)	-RRB-
cord-312001-8p7scli8	82	1	[	[	-LRB-
cord-312001-8p7scli8	82	2	41,42	41,42	CD
cord-312001-8p7scli8	82	3	]	]	-RRB-
cord-312001-8p7scli8	82	4	detect	detect	VB
cord-312001-8p7scli8	82	5	viral	viral	JJ
cord-312001-8p7scli8	82	6	RNAs	rna	NNS
cord-312001-8p7scli8	82	7	in	in	IN
cord-312001-8p7scli8	82	8	the	the	DT
cord-312001-8p7scli8	82	9	cytosol	cytosol	NN
cord-312001-8p7scli8	82	10	,	,	,
cord-312001-8p7scli8	82	11	whereas	whereas	IN
cord-312001-8p7scli8	82	12	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	82	13	viral	viral	JJ
cord-312001-8p7scli8	82	14	DNA	dna	NN
cord-312001-8p7scli8	82	15	is	be	VBZ
cord-312001-8p7scli8	82	16	mainly	mainly	RB
cord-312001-8p7scli8	82	17	recognized	recognize	VBN
cord-312001-8p7scli8	82	18	by	by	IN
cord-312001-8p7scli8	82	19	cyclic	cyclic	JJ
cord-312001-8p7scli8	82	20	-	-	HYPH
cord-312001-8p7scli8	82	21	GMP	GMP	NNP
cord-312001-8p7scli8	82	22	-	-	HYPH
cord-312001-8p7scli8	82	23	AMP	AMP	NNP
cord-312001-8p7scli8	82	24	(	(	-LRB-
cord-312001-8p7scli8	82	25	cGAMP	cGAMP	NNP
cord-312001-8p7scli8	82	26	)	)	-RRB-
cord-312001-8p7scli8	82	27	synthase	synthase	NN
cord-312001-8p7scli8	82	28	(	(	-LRB-
cord-312001-8p7scli8	82	29	cGAS	cga	VBG
cord-312001-8p7scli8	82	30	)	)	-RRB-
cord-312001-8p7scli8	82	31	[	[	-LRB-
cord-312001-8p7scli8	82	32	43	43	CD
cord-312001-8p7scli8	82	33	]	]	-RRB-
cord-312001-8p7scli8	82	34	.	.	.
cord-312001-8p7scli8	83	1	Therefore	therefore	RB
cord-312001-8p7scli8	83	2	,	,	,
cord-312001-8p7scli8	83	3	the	the	DT
cord-312001-8p7scli8	83	4	nature	nature	NN
cord-312001-8p7scli8	83	5	of	of	IN
cord-312001-8p7scli8	83	6	the	the	DT
cord-312001-8p7scli8	83	7	viral	viral	JJ
cord-312001-8p7scli8	83	8	particle	particle	NN
cord-312001-8p7scli8	83	9	(	(	-LRB-
cord-312001-8p7scli8	83	10	e.g.	e.g.	RB
cord-312001-8p7scli8	83	11	,	,	,
cord-312001-8p7scli8	83	12	enveloped	envelop	VBN
cord-312001-8p7scli8	83	13	vs.	vs.	IN
cord-312001-8p7scli8	83	14	non	non	JJ
cord-312001-8p7scli8	83	15	-	-	JJ
cord-312001-8p7scli8	83	16	enveloped	enveloped	JJ
cord-312001-8p7scli8	83	17	)	)	-RRB-
cord-312001-8p7scli8	83	18	and	and	CC
cord-312001-8p7scli8	83	19	the	the	DT
cord-312001-8p7scli8	83	20	viral	viral	JJ
cord-312001-8p7scli8	83	21	genome	genome	NN
cord-312001-8p7scli8	83	22	(	(	-LRB-
cord-312001-8p7scli8	83	23	e.g.	e.g.	RB
cord-312001-8p7scli8	83	24	,	,	,
cord-312001-8p7scli8	83	25	DNA	DNA	NNP
cord-312001-8p7scli8	83	26	vs.	vs.	FW
cord-312001-8p7scli8	83	27	RNA	RNA	NNP
cord-312001-8p7scli8	83	28	)	)	-RRB-
cord-312001-8p7scli8	83	29	dictates	dictate	VBZ
cord-312001-8p7scli8	83	30	which	which	WDT
cord-312001-8p7scli8	83	31	of	of	IN
cord-312001-8p7scli8	83	32	these	these	DT
cord-312001-8p7scli8	83	33	receptors	receptor	NNS
cord-312001-8p7scli8	83	34	recognizes	recognize	VBZ
cord-312001-8p7scli8	83	35	the	the	DT
cord-312001-8p7scli8	83	36	infection	infection	NN
cord-312001-8p7scli8	83	37	first	first	RB
cord-312001-8p7scli8	84	1	(	(	-LRB-
cord-312001-8p7scli8	84	2	Figure	figure	NN
cord-312001-8p7scli8	84	3	1	1	CD
cord-312001-8p7scli8	84	4	 	 	_SP
cord-312001-8p7scli8	84	5	Single	Single	NNP
cord-312001-8p7scli8	84	6	-	-	HYPH
cord-312001-8p7scli8	84	7	stranded	strand	VBN
cord-312001-8p7scli8	84	8	RNA	RNA	NNP
cord-312001-8p7scli8	84	9	(	(	-LRB-
cord-312001-8p7scli8	84	10	ssRNA	ssrna	NN
cord-312001-8p7scli8	84	11	)	)	-RRB-
cord-312001-8p7scli8	84	12	is	be	VBZ
cord-312001-8p7scli8	84	13	a	a	DT
cord-312001-8p7scli8	84	14	potent	potent	JJ
cord-312001-8p7scli8	84	15	TLR7	TLR7	NNP
cord-312001-8p7scli8	84	16	and	and	CC
cord-312001-8p7scli8	84	17	TLR8	TLR8	NNP
cord-312001-8p7scli8	84	18	ligand	ligand	NN
cord-312001-8p7scli8	84	19	,	,	,
cord-312001-8p7scli8	84	20	while	while	IN
cord-312001-8p7scli8	84	21	TLR3	TLR3	NNP
cord-312001-8p7scli8	84	22	is	be	VBZ
cord-312001-8p7scli8	84	23	specific	specific	JJ
cord-312001-8p7scli8	84	24	for	for	IN
cord-312001-8p7scli8	84	25	dsRNA	dsrna	NN
cord-312001-8p7scli8	84	26	.	.	.
cord-312001-8p7scli8	85	1	TLR3	TLR3	NNP
cord-312001-8p7scli8	85	2	,	,	,
cord-312001-8p7scli8	85	3	for	for	IN
cord-312001-8p7scli8	85	4	example	example	NN
cord-312001-8p7scli8	85	5	,	,	,
cord-312001-8p7scli8	85	6	recognizes	recognize	VBZ
cord-312001-8p7scli8	85	7	dsRNA	dsrna	NN
cord-312001-8p7scli8	85	8	viruses	virus	NNS
cord-312001-8p7scli8	85	9	from	from	IN
cord-312001-8p7scli8	85	10	Reoviruses	Reoviruses	NNP
cord-312001-8p7scli8	85	11	[	[	-LRB-
cord-312001-8p7scli8	85	12	36	36	CD
cord-312001-8p7scli8	85	13	]	]	-RRB-
cord-312001-8p7scli8	85	14	,	,	,
cord-312001-8p7scli8	85	15	but	but	CC
cord-312001-8p7scli8	85	16	can	can	MD
cord-312001-8p7scli8	85	17	probably	probably	RB
cord-312001-8p7scli8	85	18	also	also	RB
cord-312001-8p7scli8	85	19	recognize	recognize	VB
cord-312001-8p7scli8	85	20	dsRNA	dsrna	JJ
cord-312001-8p7scli8	85	21	intermediates	intermediate	NNS
cord-312001-8p7scli8	85	22	from	from	IN
cord-312001-8p7scli8	85	23	(	(	-LRB-
cord-312001-8p7scli8	85	24	+	+	CC
cord-312001-8p7scli8	85	25	)	)	-RRB-
cord-312001-8p7scli8	85	26	strand	strand	NN
cord-312001-8p7scli8	85	27	RNA	RNA	NNP
cord-312001-8p7scli8	85	28	viruses	virus	NNS
cord-312001-8p7scli8	85	29	like	like	IN
cord-312001-8p7scli8	86	1	coxsackievirus	coxsackievirus	NNP
cord-312001-8p7scli8	86	2	and	and	CC
cord-312001-8p7scli8	86	3	West	West	NNP
cord-312001-8p7scli8	86	4	Nile	Nile	NNP
cord-312001-8p7scli8	86	5	virus	virus	NN
cord-312001-8p7scli8	86	6	(	(	-LRB-
cord-312001-8p7scli8	86	7	WNV	WNV	NNP
cord-312001-8p7scli8	86	8	)	)	-RRB-
cord-312001-8p7scli8	86	9	and	and	CC
cord-312001-8p7scli8	87	1	(	(	-LRB-
cord-312001-8p7scli8	87	2	-	-	:
cord-312001-8p7scli8	87	3	)	)	-RRB-
cord-312001-8p7scli8	87	4	strand	strand	NN
cord-312001-8p7scli8	87	5	RNA	RNA	NNP
cord-312001-8p7scli8	87	6	viruses	virus	NNS
cord-312001-8p7scli8	87	7	like	like	IN
cord-312001-8p7scli8	87	8	the	the	DT
cord-312001-8p7scli8	87	9	human	human	JJ
cord-312001-8p7scli8	87	10	respiratory	respiratory	JJ
cord-312001-8p7scli8	87	11	syncytial	syncytial	JJ
cord-312001-8p7scli8	87	12	virus	virus	NN
cord-312001-8p7scli8	87	13	(	(	-LRB-
cord-312001-8p7scli8	87	14	HRSV	HRSV	NNP
cord-312001-8p7scli8	87	15	)	)	-RRB-
cord-312001-8p7scli8	88	1	[	[	-LRB-
cord-312001-8p7scli8	88	2	46	46	CD
cord-312001-8p7scli8	88	3	]	]	-RRB-
cord-312001-8p7scli8	88	4	.	.	.
cord-312001-8p7scli8	89	1	Indeed	indeed	RB
cord-312001-8p7scli8	89	2	,	,	,
cord-312001-8p7scli8	89	3	all	all	DT
cord-312001-8p7scli8	89	4	RNA	RNA	NNP
cord-312001-8p7scli8	89	5	viruses	virus	NNS
cord-312001-8p7scli8	89	6	are	be	VBP
cord-312001-8p7scli8	89	7	thought	think	VBN
cord-312001-8p7scli8	89	8	to	to	TO
cord-312001-8p7scli8	89	9	produce	produce	VB
cord-312001-8p7scli8	89	10	dsRNA	dsrna	NN
cord-312001-8p7scli8	89	11	intermediates	intermediate	NNS
cord-312001-8p7scli8	89	12	as	as	IN
cord-312001-8p7scli8	89	13	part	part	NN
cord-312001-8p7scli8	89	14	of	of	IN
cord-312001-8p7scli8	89	15	their	-PRON-	PRP$
cord-312001-8p7scli8	89	16	replication	replication	NN
cord-312001-8p7scli8	89	17	cycle	cycle	NN
cord-312001-8p7scli8	89	18	,	,	,
cord-312001-8p7scli8	89	19	so	so	RB
cord-312001-8p7scli8	89	20	both	both	DT
cord-312001-8p7scli8	89	21	ssRNA	ssRNA	.
cord-312001-8p7scli8	90	1	and	and	CC
cord-312001-8p7scli8	90	2	dsRNA	dsrna	NN
cord-312001-8p7scli8	90	3	viruses	virus	NNS
cord-312001-8p7scli8	90	4	have	have	VBP
cord-312001-8p7scli8	90	5	the	the	DT
cord-312001-8p7scli8	90	6	potential	potential	NN
cord-312001-8p7scli8	90	7	to	to	TO
cord-312001-8p7scli8	90	8	be	be	VB
cord-312001-8p7scli8	90	9	sensed	sense	VBN
cord-312001-8p7scli8	90	10	by	by	IN
cord-312001-8p7scli8	90	11	TLR3	TLR3	NNP
cord-312001-8p7scli8	90	12	.	.	.
cord-312001-8p7scli8	91	1	TLR7	TLR7	NNP
cord-312001-8p7scli8	91	2	and	and	CC
cord-312001-8p7scli8	91	3	8	8	CD
cord-312001-8p7scli8	91	4	,	,	,
cord-312001-8p7scli8	91	5	on	on	IN
cord-312001-8p7scli8	91	6	the	the	DT
cord-312001-8p7scli8	91	7	other	other	JJ
cord-312001-8p7scli8	91	8	hand	hand	NN
cord-312001-8p7scli8	91	9	,	,	,
cord-312001-8p7scli8	91	10	have	have	VBP
cord-312001-8p7scli8	91	11	been	be	VBN
cord-312001-8p7scli8	91	12	shown	show	VBN
cord-312001-8p7scli8	91	13	to	to	TO
cord-312001-8p7scli8	91	14	prefer	prefer	VB
cord-312001-8p7scli8	91	15	ssRNA	ssrna	NN
cord-312001-8p7scli8	91	16	ligands	ligand	NNS
cord-312001-8p7scli8	91	17	from	from	IN
cord-312001-8p7scli8	91	18	(	(	-LRB-
cord-312001-8p7scli8	92	1	-	-	:
cord-312001-8p7scli8	92	2	)	)	-RRB-
cord-312001-8p7scli8	92	3	strand	strand	NN
cord-312001-8p7scli8	92	4	RNA	RNA	NNP
cord-312001-8p7scli8	92	5	viruses	virus	NNS
cord-312001-8p7scli8	92	6	such	such	JJ
cord-312001-8p7scli8	92	7	as	as	IN
cord-312001-8p7scli8	92	8	vesicular	vesicular	JJ
cord-312001-8p7scli8	92	9	stomatitis	stomatitis	NN
cord-312001-8p7scli8	92	10	virus	virus	NN
cord-312001-8p7scli8	92	11	(	(	-LRB-
cord-312001-8p7scli8	92	12	VSV	VSV	NNP
cord-312001-8p7scli8	92	13	)	)	-RRB-
cord-312001-8p7scli8	92	14	and	and	CC
cord-312001-8p7scli8	92	15	influenza	influenza	NN
cord-312001-8p7scli8	92	16	A	a	DT
cord-312001-8p7scli8	92	17	virus	virus	NN
cord-312001-8p7scli8	92	18	(	(	-LRB-
cord-312001-8p7scli8	92	19	IAV	IAV	NNP
cord-312001-8p7scli8	92	20	)	)	-RRB-
cord-312001-8p7scli8	92	21	[	[	-LRB-
cord-312001-8p7scli8	92	22	37	37	CD
cord-312001-8p7scli8	92	23	,	,	,
cord-312001-8p7scli8	92	24	47	47	CD
cord-312001-8p7scli8	92	25	]	]	-RRB-
cord-312001-8p7scli8	92	26	.	.	.
cord-312001-8p7scli8	93	1	When	when	WRB
cord-312001-8p7scli8	93	2	it	-PRON-	PRP
cord-312001-8p7scli8	93	3	comes	come	VBZ
cord-312001-8p7scli8	93	4	to	to	IN
cord-312001-8p7scli8	93	5	RLRs	rlr	NNS
cord-312001-8p7scli8	93	6	,	,	,
cord-312001-8p7scli8	93	7	most	most	JJS
cord-312001-8p7scli8	93	8	RNA	RNA	NNP
cord-312001-8p7scli8	93	9	viruses	virus	NNS
cord-312001-8p7scli8	93	10	have	have	VBP
cord-312001-8p7scli8	93	11	been	be	VBN
cord-312001-8p7scli8	93	12	shown	show	VBN
cord-312001-8p7scli8	93	13	to	to	TO
cord-312001-8p7scli8	93	14	be	be	VB
cord-312001-8p7scli8	93	15	detected	detect	VBN
cord-312001-8p7scli8	93	16	by	by	IN
cord-312001-8p7scli8	93	17	RIG	rig	NN
cord-312001-8p7scli8	93	18	-	-	:
cord-312001-8p7scli8	93	19	I	I	NNP
cord-312001-8p7scli8	93	20	or	or	CC
cord-312001-8p7scli8	93	21	MDA5	MDA5	NNP
cord-312001-8p7scli8	93	22	,	,	,
cord-312001-8p7scli8	93	23	as	as	IN
cord-312001-8p7scli8	93	24	these	these	DT
cord-312001-8p7scli8	93	25	receptors	receptor	NNS
cord-312001-8p7scli8	93	26	have	have	VBP
cord-312001-8p7scli8	93	27	a	a	DT
cord-312001-8p7scli8	93	28	high	high	JJ
cord-312001-8p7scli8	93	29	affinity	affinity	NN
cord-312001-8p7scli8	93	30	to	to	IN
cord-312001-8p7scli8	93	31	dsRNAs	dsRNAs	NNP
cord-312001-8p7scli8	93	32	.	.	.
cord-312001-8p7scli8	94	1	While	while	IN
cord-312001-8p7scli8	94	2	RIG	rig	NN
cord-312001-8p7scli8	94	3	-	-	:
cord-312001-8p7scli8	94	4	I	-PRON-	PRP
cord-312001-8p7scli8	94	5	prefers	prefer	VBZ
cord-312001-8p7scli8	94	6	viral	viral	JJ
cord-312001-8p7scli8	94	7	RNAs	rna	NNS
cord-312001-8p7scli8	94	8	bearing	bear	VBG
cord-312001-8p7scli8	94	9	di	di	NNP
cord-312001-8p7scli8	94	10	-	-	,
cord-312001-8p7scli8	94	11	or	or	CC
cord-312001-8p7scli8	94	12	tri	tri	JJ
cord-312001-8p7scli8	94	13	-	-	JJ
cord-312001-8p7scli8	94	14	phosphate	phosphate	JJ
cord-312001-8p7scli8	94	15	groups	group	NNS
cord-312001-8p7scli8	94	16	at	at	IN
cord-312001-8p7scli8	94	17	their	-PRON-	PRP$
cord-312001-8p7scli8	94	18	5	5	CD
cord-312001-8p7scli8	94	19	 	 	_SP
cord-312001-8p7scli8	94	20	While	while	IN
cord-312001-8p7scli8	94	21	the	the	DT
cord-312001-8p7scli8	94	22	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	94	23	recognition	recognition	NN
cord-312001-8p7scli8	94	24	of	of	IN
cord-312001-8p7scli8	94	25	viral	viral	JJ
cord-312001-8p7scli8	94	26	RNA	RNA	NNP
cord-312001-8p7scli8	94	27	is	be	VBZ
cord-312001-8p7scli8	94	28	almost	almost	RB
cord-312001-8p7scli8	94	29	exclusively	exclusively	RB
cord-312001-8p7scli8	94	30	mediated	mediate	VBN
cord-312001-8p7scli8	94	31	by	by	IN
cord-312001-8p7scli8	94	32	RLRs	rlr	NNS
cord-312001-8p7scli8	94	33	,	,	,
cord-312001-8p7scli8	94	34	several	several	JJ
cord-312001-8p7scli8	94	35	proteins	protein	NNS
cord-312001-8p7scli8	94	36	have	have	VBP
cord-312001-8p7scli8	94	37	been	be	VBN
cord-312001-8p7scli8	94	38	proposed	propose	VBN
cord-312001-8p7scli8	94	39	to	to	TO
cord-312001-8p7scli8	94	40	play	play	VB
cord-312001-8p7scli8	94	41	a	a	DT
cord-312001-8p7scli8	94	42	role	role	NN
cord-312001-8p7scli8	94	43	in	in	IN
cord-312001-8p7scli8	94	44	DNA	dna	NN
cord-312001-8p7scli8	94	45	sensing	sensing	NN
cord-312001-8p7scli8	94	46	and	and	CC
cord-312001-8p7scli8	94	47	triggering	trigger	VBG
cord-312001-8p7scli8	94	48	innate	innate	JJ
cord-312001-8p7scli8	94	49	immune	immune	JJ
cord-312001-8p7scli8	94	50	responses	response	NNS
cord-312001-8p7scli8	94	51	,	,	,
cord-312001-8p7scli8	94	52	such	such	JJ
cord-312001-8p7scli8	94	53	as	as	IN
cord-312001-8p7scli8	94	54	the	the	DT
cord-312001-8p7scli8	94	55	DNA	dna	NN
cord-312001-8p7scli8	94	56	-	-	HYPH
cord-312001-8p7scli8	94	57	dependent	dependent	JJ
cord-312001-8p7scli8	94	58	activator	activator	NN
cord-312001-8p7scli8	94	59	of	of	IN
cord-312001-8p7scli8	94	60	IFN	IFN	NNP
cord-312001-8p7scli8	94	61	-	-	HYPH
cord-312001-8p7scli8	94	62	regulatory	regulatory	JJ
cord-312001-8p7scli8	94	63	factors	factor	NNS
cord-312001-8p7scli8	94	64	(	(	-LRB-
cord-312001-8p7scli8	94	65	DAI	DAI	NNP
cord-312001-8p7scli8	94	66	)	)	-RRB-
cord-312001-8p7scli8	94	67	,	,	,
cord-312001-8p7scli8	94	68	DDX41	DDX41	NNP
cord-312001-8p7scli8	94	69	,	,	,
cord-312001-8p7scli8	94	70	RNA	RNA	NNP
cord-312001-8p7scli8	94	71	polymerase	polymerase	NN
cord-312001-8p7scli8	94	72	III	III	NNP
cord-312001-8p7scli8	94	73	,	,	,
cord-312001-8p7scli8	94	74	IFI16	ifi16	NN
cord-312001-8p7scli8	94	75	and	and	CC
cord-312001-8p7scli8	94	76	DNA	DNA	NNP
cord-312001-8p7scli8	94	77	-	-	HYPH
cord-312001-8p7scli8	94	78	PK	pk	NN
cord-312001-8p7scli8	94	79	[	[	-LRB-
cord-312001-8p7scli8	94	80	62	62	CD
cord-312001-8p7scli8	94	81	]	]	-RRB-
cord-312001-8p7scli8	94	82	[	[	-LRB-
cord-312001-8p7scli8	94	83	63	63	CD
cord-312001-8p7scli8	94	84	]	]	-RRB-
cord-312001-8p7scli8	94	85	[	[	-LRB-
cord-312001-8p7scli8	94	86	64	64	CD
cord-312001-8p7scli8	94	87	]	]	-RRB-
cord-312001-8p7scli8	94	88	[	[	-LRB-
cord-312001-8p7scli8	94	89	65	65	CD
cord-312001-8p7scli8	94	90	]	]	-RRB-
cord-312001-8p7scli8	95	1	[	[	-LRB-
cord-312001-8p7scli8	95	2	66	66	CD
cord-312001-8p7scli8	95	3	]	]	-RRB-
cord-312001-8p7scli8	95	4	[	[	-LRB-
cord-312001-8p7scli8	95	5	67	67	CD
cord-312001-8p7scli8	95	6	]	]	-RRB-
cord-312001-8p7scli8	95	7	.	.	.
cord-312001-8p7scli8	96	1	However	however	RB
cord-312001-8p7scli8	96	2	,	,	,
cord-312001-8p7scli8	96	3	among	among	IN
cord-312001-8p7scli8	96	4	all	all	PDT
cord-312001-8p7scli8	96	5	the	the	DT
cord-312001-8p7scli8	96	6	proposed	propose	VBN
cord-312001-8p7scli8	96	7	sensors	sensor	NNS
cord-312001-8p7scli8	96	8	,	,	,
cord-312001-8p7scli8	96	9	only	only	RB
cord-312001-8p7scli8	96	10	cGAS	cgas	JJ
cord-312001-8p7scli8	96	11	knock	knock	NN
cord-312001-8p7scli8	96	12	-	-	HYPH
cord-312001-8p7scli8	96	13	outs	out	NNS
cord-312001-8p7scli8	96	14	can	can	MD
cord-312001-8p7scli8	96	15	completely	completely	RB
cord-312001-8p7scli8	96	16	shut	shut	VB
cord-312001-8p7scli8	96	17	down	down	RP
cord-312001-8p7scli8	96	18	IFN	IFN	NNP
cord-312001-8p7scli8	96	19	production	production	NN
cord-312001-8p7scli8	96	20	in	in	IN
cord-312001-8p7scli8	96	21	response	response	NN
cord-312001-8p7scli8	96	22	to	to	IN
cord-312001-8p7scli8	96	23	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	96	24	DNA	DNA	NNP
cord-312001-8p7scli8	96	25	[	[	-LRB-
cord-312001-8p7scli8	96	26	43	43	CD
cord-312001-8p7scli8	96	27	]	]	-RRB-
cord-312001-8p7scli8	96	28	.	.	.
cord-312001-8p7scli8	97	1	The	the	DT
cord-312001-8p7scli8	97	2	cGAS	cgas	JJ
cord-312001-8p7scli8	97	3	protein	protein	NN
cord-312001-8p7scli8	97	4	is	be	VBZ
cord-312001-8p7scli8	97	5	now	now	RB
cord-312001-8p7scli8	97	6	thought	think	VBN
cord-312001-8p7scli8	97	7	to	to	TO
cord-312001-8p7scli8	97	8	be	be	VB
cord-312001-8p7scli8	97	9	the	the	DT
cord-312001-8p7scli8	97	10	major	major	JJ
cord-312001-8p7scli8	97	11	viral	viral	JJ
cord-312001-8p7scli8	97	12	DNA	dna	NN
cord-312001-8p7scli8	97	13	sensor	sensor	NN
cord-312001-8p7scli8	97	14	and	and	CC
cord-312001-8p7scli8	97	15	has	have	VBZ
cord-312001-8p7scli8	97	16	been	be	VBN
cord-312001-8p7scli8	97	17	shown	show	VBN
cord-312001-8p7scli8	97	18	to	to	TO
cord-312001-8p7scli8	97	19	detect	detect	VB
cord-312001-8p7scli8	97	20	adenovirus	adenovirus	NN
cord-312001-8p7scli8	97	21	,	,	,
cord-312001-8p7scli8	97	22	human	human	JJ
cord-312001-8p7scli8	97	23	papillomavirus	papillomavirus	NN
cord-312001-8p7scli8	97	24	(	(	-LRB-
cord-312001-8p7scli8	97	25	HPV	HPV	NNP
cord-312001-8p7scli8	97	26	)	)	-RRB-
cord-312001-8p7scli8	97	27	,	,	,
cord-312001-8p7scli8	97	28	herpes	herpes	NN
cord-312001-8p7scli8	97	29	simplex	simplex	NN
cord-312001-8p7scli8	97	30	virus-1	virus-1	NN
cord-312001-8p7scli8	97	31	(	(	-LRB-
cord-312001-8p7scli8	97	32	HSV-1	hsv-1	NN
cord-312001-8p7scli8	97	33	)	)	-RRB-
cord-312001-8p7scli8	97	34	and	and	CC
cord-312001-8p7scli8	97	35	cytomegalovirus	cytomegalovirus	NNP
cord-312001-8p7scli8	97	36	(	(	-LRB-
cord-312001-8p7scli8	97	37	CMV	CMV	NNP
cord-312001-8p7scli8	97	38	)	)	-RRB-
cord-312001-8p7scli8	98	1	[	[	-LRB-
cord-312001-8p7scli8	98	2	43	43	CD
cord-312001-8p7scli8	98	3	,	,	,
cord-312001-8p7scli8	98	4	[	[	-LRB-
cord-312001-8p7scli8	98	5	68	68	CD
cord-312001-8p7scli8	98	6	]	]	-RRB-
cord-312001-8p7scli8	98	7	[	[	-LRB-
cord-312001-8p7scli8	98	8	69	69	CD
cord-312001-8p7scli8	98	9	]	]	-RRB-
cord-312001-8p7scli8	98	10	[	[	-LRB-
cord-312001-8p7scli8	98	11	70	70	CD
cord-312001-8p7scli8	98	12	]	]	-RRB-
cord-312001-8p7scli8	98	13	.	.	.
cord-312001-8p7scli8	99	1	AIM2	AIM2	NNP
cord-312001-8p7scli8	99	2	has	have	VBZ
cord-312001-8p7scli8	99	3	also	also	RB
cord-312001-8p7scli8	99	4	been	be	VBN
cord-312001-8p7scli8	99	5	shown	show	VBN
cord-312001-8p7scli8	99	6	to	to	TO
cord-312001-8p7scli8	99	7	activate	activate	VB
cord-312001-8p7scli8	99	8	the	the	DT
cord-312001-8p7scli8	99	9	inflammasome	inflammasome	NN
cord-312001-8p7scli8	99	10	upon	upon	IN
cord-312001-8p7scli8	99	11	DNA	dna	NN
cord-312001-8p7scli8	99	12	stimulation	stimulation	NN
cord-312001-8p7scli8	99	13	[	[	-LRB-
cord-312001-8p7scli8	99	14	71	71	CD
cord-312001-8p7scli8	99	15	]	]	-RRB-
cord-312001-8p7scli8	99	16	but	but	CC
cord-312001-8p7scli8	99	17	will	will	MD
cord-312001-8p7scli8	99	18	not	not	RB
cord-312001-8p7scli8	99	19	be	be	VB
cord-312001-8p7scli8	99	20	discussed	discuss	VBN
cord-312001-8p7scli8	99	21	in	in	IN
cord-312001-8p7scli8	99	22	this	this	DT
cord-312001-8p7scli8	99	23	review	review	NN
cord-312001-8p7scli8	99	24	.	.	.
cord-312001-8p7scli8	100	1	RNA	RNA	NNP
cord-312001-8p7scli8	100	2	ligands	ligand	NNS
cord-312001-8p7scli8	100	3	cause	cause	VBP
cord-312001-8p7scli8	100	4	the	the	DT
cord-312001-8p7scli8	100	5	endosomal	endosomal	NNP
cord-312001-8p7scli8	100	6	transmembrane	transmembrane	NN
cord-312001-8p7scli8	100	7	TLR3	TLR3	NNP
cord-312001-8p7scli8	100	8	,	,	,
cord-312001-8p7scli8	100	9	7	7	CD
cord-312001-8p7scli8	100	10	and	and	CC
cord-312001-8p7scli8	100	11	8	8	CD
cord-312001-8p7scli8	100	12	to	to	TO
cord-312001-8p7scli8	100	13	dimerize	dimerize	VB
cord-312001-8p7scli8	100	14	and	and	CC
cord-312001-8p7scli8	100	15	then	then	RB
cord-312001-8p7scli8	100	16	to	to	IN
cord-312001-8p7scli8	100	17	oligomerize	oligomerize	VB
cord-312001-8p7scli8	100	18	through	through	IN
cord-312001-8p7scli8	100	19	their	-PRON-	PRP$
cord-312001-8p7scli8	100	20	cytoplasmic	cytoplasmic	JJ
cord-312001-8p7scli8	100	21	TIR	tir	NN
cord-312001-8p7scli8	100	22	(	(	-LRB-
cord-312001-8p7scli8	100	23	Toll	Toll	NNP
cord-312001-8p7scli8	100	24	/	/	SYM
cord-312001-8p7scli8	100	25	IL-1	IL-1	NNP
cord-312001-8p7scli8	100	26	receptor	receptor	NN
cord-312001-8p7scli8	100	27	)	)	-RRB-
cord-312001-8p7scli8	100	28	domains	domain	NNS
cord-312001-8p7scli8	100	29	.	.	.
cord-312001-8p7scli8	101	1	This	this	DT
cord-312001-8p7scli8	101	2	allows	allow	VBZ
cord-312001-8p7scli8	101	3	TLRs	tlr	NNS
cord-312001-8p7scli8	101	4	to	to	TO
cord-312001-8p7scli8	101	5	recruit	recruit	VB
cord-312001-8p7scli8	101	6	signaling	signal	VBG
cord-312001-8p7scli8	101	7	adaptors	adaptor	NNS
cord-312001-8p7scli8	101	8	via	via	IN
cord-312001-8p7scli8	101	9	TIR	TIR	NNP
cord-312001-8p7scli8	101	10	-	-	HYPH
cord-312001-8p7scli8	101	11	TIR	TIR	NNP
cord-312001-8p7scli8	101	12	interactions	interaction	NNS
cord-312001-8p7scli8	101	13	[	[	-LRB-
cord-312001-8p7scli8	101	14	35	35	CD
cord-312001-8p7scli8	101	15	]	]	-RRB-
cord-312001-8p7scli8	101	16	.	.	.
cord-312001-8p7scli8	102	1	TLR3	TLR3	NNP
cord-312001-8p7scli8	102	2	recruits	recruit	VBZ
cord-312001-8p7scli8	102	3	the	the	DT
cord-312001-8p7scli8	102	4	adaptor	adaptor	NN
cord-312001-8p7scli8	102	5	protein	protein	NN
cord-312001-8p7scli8	102	6	TRIF	TRIF	NNP
cord-312001-8p7scli8	103	1	(	(	-LRB-
cord-312001-8p7scli8	103	2	TIR	TIR	NNP
cord-312001-8p7scli8	103	3	-	-	HYPH
cord-312001-8p7scli8	103	4	domain	domain	NN
cord-312001-8p7scli8	103	5	-	-	HYPH
cord-312001-8p7scli8	103	6	containing	contain	VBG
cord-312001-8p7scli8	103	7	adapter	adapter	NN
cord-312001-8p7scli8	103	8	-	-	HYPH
cord-312001-8p7scli8	103	9	inducing	induce	VBG
cord-312001-8p7scli8	103	10	IFN	IFN	NNP
cord-312001-8p7scli8	103	11	-	-	HYPH
cord-312001-8p7scli8	103	12	β	β	NNP
cord-312001-8p7scli8	103	13	)	)	-RRB-
cord-312001-8p7scli8	103	14	[	[	-LRB-
cord-312001-8p7scli8	103	15	72	72	CD
cord-312001-8p7scli8	103	16	,	,	,
cord-312001-8p7scli8	103	17	73	73	CD
cord-312001-8p7scli8	103	18	]	]	-RRB-
cord-312001-8p7scli8	103	19	.	.	.
cord-312001-8p7scli8	104	1	TRIF	TRIF	NNP
cord-312001-8p7scli8	104	2	is	be	VBZ
cord-312001-8p7scli8	104	3	able	able	JJ
cord-312001-8p7scli8	104	4	to	to	TO
cord-312001-8p7scli8	104	5	play	play	VB
cord-312001-8p7scli8	104	6	a	a	DT
cord-312001-8p7scli8	104	7	dual	dual	JJ
cord-312001-8p7scli8	104	8	role	role	NN
cord-312001-8p7scli8	104	9	by	by	IN
cord-312001-8p7scli8	104	10	inducing	induce	VBG
cord-312001-8p7scli8	104	11	the	the	DT
cord-312001-8p7scli8	104	12	IFN	IFN	NNP
cord-312001-8p7scli8	104	13	or	or	CC
cord-312001-8p7scli8	104	14	the	the	DT
cord-312001-8p7scli8	104	15	NF	NF	NNP
cord-312001-8p7scli8	104	16	-	-	HYPH
cord-312001-8p7scli8	104	17	kB	kB	NNP
cord-312001-8p7scli8	104	18	pathways	pathway	NNS
cord-312001-8p7scli8	104	19	.	.	.
cord-312001-8p7scli8	105	1	When	when	WRB
cord-312001-8p7scli8	105	2	it	-PRON-	PRP
cord-312001-8p7scli8	105	3	comes	come	VBZ
cord-312001-8p7scli8	105	4	to	to	IN
cord-312001-8p7scli8	105	5	IFN	IFN	NNP
cord-312001-8p7scli8	105	6	,	,	,
cord-312001-8p7scli8	105	7	after	after	IN
cord-312001-8p7scli8	105	8	activation	activation	NN
cord-312001-8p7scli8	105	9	,	,	,
cord-312001-8p7scli8	105	10	TRIF	TRIF	NNP
cord-312001-8p7scli8	105	11	recruits	recruit	VBZ
cord-312001-8p7scli8	105	12	the	the	DT
cord-312001-8p7scli8	105	13	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	105	14	ligase	ligase	NN
cord-312001-8p7scli8	106	1	TRAF3	TRAF3	NNP
cord-312001-8p7scli8	107	1	(	(	-LRB-
cord-312001-8p7scli8	107	2	tumor	tumor	NN
cord-312001-8p7scli8	107	3	necrosis	necrosis	NN
cord-312001-8p7scli8	107	4	factor	factor	NN
cord-312001-8p7scli8	107	5	receptor	receptor	NN
cord-312001-8p7scli8	107	6	-	-	HYPH
cord-312001-8p7scli8	107	7	associated	associate	VBN
cord-312001-8p7scli8	107	8	factor	factor	NN
cord-312001-8p7scli8	107	9	3	3	CD
cord-312001-8p7scli8	107	10	)	)	-RRB-
cord-312001-8p7scli8	107	11	through	through	IN
cord-312001-8p7scli8	107	12	an	an	DT
cord-312001-8p7scli8	107	13	ubiquitination	ubiquitination	NN
cord-312001-8p7scli8	107	14	mechanism	mechanism	NN
cord-312001-8p7scli8	107	15	which	which	WDT
cord-312001-8p7scli8	107	16	in	in	IN
cord-312001-8p7scli8	107	17	turn	turn	NN
cord-312001-8p7scli8	107	18	recruits	recruit	NNS
cord-312001-8p7scli8	108	1	TANK	tank	NN
cord-312001-8p7scli8	108	2	-	-	HYPH
cord-312001-8p7scli8	108	3	binding	bind	VBG
cord-312001-8p7scli8	108	4	kinase	kinase	NN
cord-312001-8p7scli8	108	5	1	1	CD
cord-312001-8p7scli8	108	6	(	(	-LRB-
cord-312001-8p7scli8	108	7	TBK1	TBK1	NNP
cord-312001-8p7scli8	108	8	)	)	-RRB-
cord-312001-8p7scli8	108	9	[	[	-LRB-
cord-312001-8p7scli8	108	10	74	74	CD
cord-312001-8p7scli8	108	11	,	,	,
cord-312001-8p7scli8	108	12	75	75	CD
cord-312001-8p7scli8	108	13	]	]	-RRB-
cord-312001-8p7scli8	108	14	.	.	.
cord-312001-8p7scli8	109	1	The	the	DT
cord-312001-8p7scli8	109	2	TRIF	TRIF	NNP
cord-312001-8p7scli8	109	3	/	/	SYM
cord-312001-8p7scli8	109	4	TBK1	TBK1	NNP
cord-312001-8p7scli8	109	5	complex	complex	NN
cord-312001-8p7scli8	109	6	is	be	VBZ
cord-312001-8p7scli8	109	7	then	then	RB
cord-312001-8p7scli8	109	8	able	able	JJ
cord-312001-8p7scli8	109	9	to	to	TO
cord-312001-8p7scli8	109	10	phosphorylate	phosphorylate	VB
cord-312001-8p7scli8	109	11	the	the	DT
cord-312001-8p7scli8	109	12	transcription	transcription	NN
cord-312001-8p7scli8	109	13	factor	factor	NN
cord-312001-8p7scli8	109	14	IRF3	IRF3	NNP
cord-312001-8p7scli8	109	15	,	,	,
cord-312001-8p7scli8	109	16	triggering	trigger	VBG
cord-312001-8p7scli8	109	17	its	-PRON-	PRP$
cord-312001-8p7scli8	109	18	dimerization	dimerization	NN
cord-312001-8p7scli8	109	19	and	and	CC
cord-312001-8p7scli8	109	20	nuclear	nuclear	JJ
cord-312001-8p7scli8	109	21	translocation	translocation	NN
cord-312001-8p7scli8	109	22	.	.	.
cord-312001-8p7scli8	110	1	Phosphorylated	Phosphorylated	NNP
cord-312001-8p7scli8	110	2	IRF3	IRF3	NNP
cord-312001-8p7scli8	110	3	dimers	dimer	NNS
cord-312001-8p7scli8	110	4	specifically	specifically	RB
cord-312001-8p7scli8	110	5	bind	bind	VB
cord-312001-8p7scli8	110	6	to	to	IN
cord-312001-8p7scli8	110	7	IFN	IFN	NNP
cord-312001-8p7scli8	110	8	-	-	HYPH
cord-312001-8p7scli8	110	9	stimulated	stimulate	VBN
cord-312001-8p7scli8	110	10	response	response	NN
cord-312001-8p7scli8	110	11	elements	element	NNS
cord-312001-8p7scli8	110	12	(	(	-LRB-
cord-312001-8p7scli8	110	13	ISREs	ISREs	NNP
cord-312001-8p7scli8	110	14	)	)	-RRB-
cord-312001-8p7scli8	110	15	present	present	JJ
cord-312001-8p7scli8	110	16	in	in	IN
cord-312001-8p7scli8	110	17	the	the	DT
cord-312001-8p7scli8	110	18	IFN	IFN	NNP
cord-312001-8p7scli8	110	19	-	-	HYPH
cord-312001-8p7scli8	110	20	β	β	NNP
cord-312001-8p7scli8	110	21	gene	gene	NN
cord-312001-8p7scli8	110	22	promoter	promoter	NN
cord-312001-8p7scli8	110	23	which	which	WDT
cord-312001-8p7scli8	110	24	leads	lead	VBZ
cord-312001-8p7scli8	110	25	to	to	IN
cord-312001-8p7scli8	110	26	the	the	DT
cord-312001-8p7scli8	110	27	transcription	transcription	NN
cord-312001-8p7scli8	110	28	of	of	IN
cord-312001-8p7scli8	110	29	this	this	DT
cord-312001-8p7scli8	110	30	cytokine	cytokine	NN
cord-312001-8p7scli8	110	31	[	[	-LRB-
cord-312001-8p7scli8	110	32	76	76	CD
cord-312001-8p7scli8	110	33	]	]	-RRB-
cord-312001-8p7scli8	110	34	.	.	.
cord-312001-8p7scli8	111	1	TRIF	TRIF	NNP
cord-312001-8p7scli8	111	2	can	can	MD
cord-312001-8p7scli8	111	3	also	also	RB
cord-312001-8p7scli8	111	4	recruit	recruit	VB
cord-312001-8p7scli8	111	5	RIPK1	RIPK1	NNP
cord-312001-8p7scli8	112	1	(	(	-LRB-
cord-312001-8p7scli8	112	2	receptor	receptor	NN
cord-312001-8p7scli8	112	3	-	-	HYPH
cord-312001-8p7scli8	112	4	interacting	interact	VBG
cord-312001-8p7scli8	112	5	serine	serine	NN
cord-312001-8p7scli8	112	6	/	/	SYM
cord-312001-8p7scli8	112	7	threonine	threonine	NN
cord-312001-8p7scli8	112	8	-	-	HYPH
cord-312001-8p7scli8	112	9	protein	protein	NN
cord-312001-8p7scli8	112	10	kinase	kinase	NN
cord-312001-8p7scli8	112	11	1	1	CD
cord-312001-8p7scli8	112	12	)	)	-RRB-
cord-312001-8p7scli8	112	13	that	that	WDT
cord-312001-8p7scli8	112	14	leads	lead	VBZ
cord-312001-8p7scli8	112	15	to	to	IN
cord-312001-8p7scli8	112	16	the	the	DT
cord-312001-8p7scli8	112	17	activation	activation	NN
cord-312001-8p7scli8	112	18	of	of	IN
cord-312001-8p7scli8	112	19	the	the	DT
cord-312001-8p7scli8	112	20	IKK	IKK	NNP
cord-312001-8p7scli8	112	21	complex	complex	NN
cord-312001-8p7scli8	112	22	,	,	,
cord-312001-8p7scli8	112	23	releasing	release	VBG
cord-312001-8p7scli8	112	24	the	the	DT
cord-312001-8p7scli8	112	25	NF	NF	NNP
cord-312001-8p7scli8	112	26	-	-	HYPH
cord-312001-8p7scli8	112	27	kB	kb	CD
cord-312001-8p7scli8	112	28	transcription	transcription	NN
cord-312001-8p7scli8	112	29	factor	factor	NN
cord-312001-8p7scli8	112	30	from	from	IN
cord-312001-8p7scli8	112	31	its	-PRON-	PRP$
cord-312001-8p7scli8	112	32	IkB	ikb	NN
cord-312001-8p7scli8	112	33	inhibitory	inhibitory	JJ
cord-312001-8p7scli8	112	34	subunit	subunit	NN
cord-312001-8p7scli8	112	35	and	and	CC
cord-312001-8p7scli8	112	36	resulting	result	VBG
cord-312001-8p7scli8	112	37	in	in	IN
cord-312001-8p7scli8	112	38	its	-PRON-	PRP$
cord-312001-8p7scli8	112	39	translocation	translocation	NN
cord-312001-8p7scli8	112	40	to	to	IN
cord-312001-8p7scli8	112	41	the	the	DT
cord-312001-8p7scli8	112	42	nucleus	nucleus	NN
cord-312001-8p7scli8	112	43	to	to	TO
cord-312001-8p7scli8	112	44	induce	induce	VB
cord-312001-8p7scli8	112	45	the	the	DT
cord-312001-8p7scli8	112	46	transcription	transcription	NN
cord-312001-8p7scli8	112	47	of	of	IN
cord-312001-8p7scli8	112	48	pro	pro	JJ
cord-312001-8p7scli8	112	49	-	-	JJ
cord-312001-8p7scli8	112	50	inflammatory	inflammatory	JJ
cord-312001-8p7scli8	112	51	cytokines	cytokine	NNS
cord-312001-8p7scli8	112	52	[	[	-LRB-
cord-312001-8p7scli8	112	53	17	17	CD
cord-312001-8p7scli8	112	54	]	]	-RRB-
cord-312001-8p7scli8	113	1	(	(	-LRB-
cord-312001-8p7scli8	113	2	Figure	figure	NN
cord-312001-8p7scli8	113	3	1	1	CD
cord-312001-8p7scli8	113	4	)	)	-RRB-
cord-312001-8p7scli8	113	5	.	.	.
cord-312001-8p7scli8	114	1	Unlike	unlike	IN
cord-312001-8p7scli8	114	2	TLR3	TLR3	NNP
cord-312001-8p7scli8	114	3	,	,	,
cord-312001-8p7scli8	114	4	the	the	DT
cord-312001-8p7scli8	114	5	activation	activation	NN
cord-312001-8p7scli8	114	6	of	of	IN
cord-312001-8p7scli8	114	7	TLR7	TLR7	NNP
cord-312001-8p7scli8	114	8	and	and	CC
cord-312001-8p7scli8	114	9	TLR8	TLR8	NNP
cord-312001-8p7scli8	114	10	recruits	recruit	NNS
cord-312001-8p7scli8	114	11	the	the	DT
cord-312001-8p7scli8	114	12	adaptor	adaptor	NN
cord-312001-8p7scli8	114	13	protein	protein	NN
cord-312001-8p7scli8	114	14	MyD88	MyD88	NNS
cord-312001-8p7scli8	114	15	(	(	-LRB-
cord-312001-8p7scli8	114	16	myeloid	myeloid	JJ
cord-312001-8p7scli8	114	17	differentiation	differentiation	NN
cord-312001-8p7scli8	114	18	primary	primary	JJ
cord-312001-8p7scli8	114	19	response	response	NN
cord-312001-8p7scli8	114	20	88	88	CD
cord-312001-8p7scli8	114	21	)	)	-RRB-
cord-312001-8p7scli8	114	22	through	through	IN
cord-312001-8p7scli8	114	23	TIR	TIR	NNP
cord-312001-8p7scli8	114	24	-	-	HYPH
cord-312001-8p7scli8	114	25	TIR	TIR	NNP
cord-312001-8p7scli8	114	26	domain	domain	NN
cord-312001-8p7scli8	114	27	interaction	interaction	NN
cord-312001-8p7scli8	114	28	.	.	.
cord-312001-8p7scli8	115	1	MyD88	myd88	JJ
cord-312001-8p7scli8	115	2	death	death	NN
cord-312001-8p7scli8	115	3	domains	domain	NNS
cord-312001-8p7scli8	115	4	oligomerize	oligomerize	NNP
cord-312001-8p7scli8	115	5	which	which	WDT
cord-312001-8p7scli8	115	6	triggers	trigger	VBZ
cord-312001-8p7scli8	115	7	the	the	DT
cord-312001-8p7scli8	115	8	formation	formation	NN
cord-312001-8p7scli8	115	9	of	of	IN
cord-312001-8p7scli8	115	10	the	the	DT
cord-312001-8p7scli8	115	11	Myddosome	Myddosome	NNP
cord-312001-8p7scli8	115	12	signaling	signal	VBG
cord-312001-8p7scli8	115	13	complex	complex	NN
cord-312001-8p7scli8	115	14	consisting	consisting	NN
cord-312001-8p7scli8	115	15	of	of	IN
cord-312001-8p7scli8	115	16	MyD88	MyD88	NNS
cord-312001-8p7scli8	115	17	and	and	CC
cord-312001-8p7scli8	115	18	the	the	DT
cord-312001-8p7scli8	115	19	IRAK	IRAK	NNP
cord-312001-8p7scli8	115	20	family	family	NN
cord-312001-8p7scli8	115	21	of	of	IN
cord-312001-8p7scli8	115	22	kinases	kinase	NNS
cord-312001-8p7scli8	115	23	(	(	-LRB-
cord-312001-8p7scli8	115	24	IL-1	IL-1	NNP
cord-312001-8p7scli8	115	25	receptor	receptor	NN
cord-312001-8p7scli8	115	26	-	-	HYPH
cord-312001-8p7scli8	115	27	associated	associate	VBN
cord-312001-8p7scli8	115	28	kinases	kinase	NNS
cord-312001-8p7scli8	115	29	)	)	-RRB-
cord-312001-8p7scli8	115	30	,	,	,
cord-312001-8p7scli8	115	31	IRAK	IRAK	NNP
cord-312001-8p7scli8	115	32	1	1	CD
cord-312001-8p7scli8	115	33	,	,	,
cord-312001-8p7scli8	115	34	2	2	CD
cord-312001-8p7scli8	115	35	and	and	CC
cord-312001-8p7scli8	115	36	4	4	CD
cord-312001-8p7scli8	115	37	.	.	.
cord-312001-8p7scli8	116	1	Through	through	IN
cord-312001-8p7scli8	116	2	a	a	DT
cord-312001-8p7scli8	116	3	series	series	NN
cord-312001-8p7scli8	116	4	of	of	IN
cord-312001-8p7scli8	116	5	phosphorylations	phosphorylation	NNS
cord-312001-8p7scli8	116	6	and	and	CC
cord-312001-8p7scli8	116	7	the	the	DT
cord-312001-8p7scli8	116	8	help	help	NN
cord-312001-8p7scli8	116	9	of	of	IN
cord-312001-8p7scli8	116	10	the	the	DT
cord-312001-8p7scli8	116	11	E3	E3	NNP
cord-312001-8p7scli8	116	12	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	116	13	ligase	ligase	NN
cord-312001-8p7scli8	116	14	TRAF6	traf6	NN
cord-312001-8p7scli8	116	15	,	,	,
cord-312001-8p7scli8	116	16	the	the	DT
cord-312001-8p7scli8	116	17	Myddosome	Myddosome	NNP
cord-312001-8p7scli8	116	18	is	be	VBZ
cord-312001-8p7scli8	116	19	able	able	JJ
cord-312001-8p7scli8	116	20	to	to	TO
cord-312001-8p7scli8	116	21	recruit	recruit	VB
cord-312001-8p7scli8	116	22	and	and	CC
cord-312001-8p7scli8	116	23	activate	activate	VB
cord-312001-8p7scli8	116	24	the	the	DT
cord-312001-8p7scli8	116	25	transcription	transcription	NN
cord-312001-8p7scli8	116	26	factors	factor	NNS
cord-312001-8p7scli8	116	27	IRF7	IRF7	NNP
cord-312001-8p7scli8	116	28	,	,	,
cord-312001-8p7scli8	116	29	IRF5	IRF5	NNP
cord-312001-8p7scli8	116	30	and	and	CC
cord-312001-8p7scli8	116	31	NF	NF	NNP
cord-312001-8p7scli8	116	32	-	-	HYPH
cord-312001-8p7scli8	116	33	kB	kB	NNP
cord-312001-8p7scli8	116	34	that	that	WDT
cord-312001-8p7scli8	116	35	translocate	translocate	VBP
cord-312001-8p7scli8	116	36	to	to	IN
cord-312001-8p7scli8	116	37	the	the	DT
cord-312001-8p7scli8	116	38	nucleus	nucleus	NN
cord-312001-8p7scli8	116	39	to	to	TO
cord-312001-8p7scli8	116	40	induce	induce	VB
cord-312001-8p7scli8	116	41	the	the	DT
cord-312001-8p7scli8	116	42	transcription	transcription	NN
cord-312001-8p7scli8	116	43	of	of	IN
cord-312001-8p7scli8	116	44	IFN	IFN	NNP
cord-312001-8p7scli8	116	45	-	-	HYPH
cord-312001-8p7scli8	116	46	α	α	NNP
cord-312001-8p7scli8	116	47	genes	gene	NNS
cord-312001-8p7scli8	116	48	and	and	CC
cord-312001-8p7scli8	116	49	other	other	JJ
cord-312001-8p7scli8	116	50	proinflammatory	proinflammatory	JJ
cord-312001-8p7scli8	116	51	cytokines	cytokine	NNS
cord-312001-8p7scli8	116	52	[	[	-LRB-
cord-312001-8p7scli8	116	53	77	77	CD
cord-312001-8p7scli8	116	54	]	]	-RRB-
cord-312001-8p7scli8	116	55	[	[	-LRB-
cord-312001-8p7scli8	116	56	78	78	CD
cord-312001-8p7scli8	116	57	]	]	-RRB-
cord-312001-8p7scli8	116	58	[	[	-LRB-
cord-312001-8p7scli8	116	59	79	79	CD
cord-312001-8p7scli8	116	60	]	]	-RRB-
cord-312001-8p7scli8	117	1	[	[	-LRB-
cord-312001-8p7scli8	117	2	80	80	CD
cord-312001-8p7scli8	117	3	]	]	-RRB-
cord-312001-8p7scli8	118	1	[	[	-LRB-
cord-312001-8p7scli8	118	2	81	81	CD
cord-312001-8p7scli8	118	3	]	]	-RRB-
cord-312001-8p7scli8	119	1	[	[	-LRB-
cord-312001-8p7scli8	119	2	82	82	CD
cord-312001-8p7scli8	119	3	]	]	-RRB-
cord-312001-8p7scli8	120	1	[	[	-LRB-
cord-312001-8p7scli8	120	2	83	83	CD
cord-312001-8p7scli8	120	3	]	]	-RRB-
cord-312001-8p7scli8	121	1	(	(	-LRB-
cord-312001-8p7scli8	121	2	Figure	figure	NN
cord-312001-8p7scli8	121	3	1	1	CD
cord-312001-8p7scli8	121	4	)	)	-RRB-
cord-312001-8p7scli8	121	5	.	.	.
cord-312001-8p7scli8	122	1	RLRs	RLRs	NNP
cord-312001-8p7scli8	122	2	(	(	-LRB-
cord-312001-8p7scli8	122	3	RIG	rig	NN
cord-312001-8p7scli8	122	4	-	-	HYPH
cord-312001-8p7scli8	122	5	I	I	NNP
cord-312001-8p7scli8	122	6	,	,	,
cord-312001-8p7scli8	122	7	MDA5	MDA5	NNP
cord-312001-8p7scli8	122	8	and	and	CC
cord-312001-8p7scli8	122	9	LGP2	LGP2	NNP
cord-312001-8p7scli8	122	10	)	)	-RRB-
cord-312001-8p7scli8	122	11	are	be	VBP
cord-312001-8p7scli8	122	12	characterized	characterize	VBN
cord-312001-8p7scli8	122	13	by	by	IN
cord-312001-8p7scli8	122	14	a	a	DT
cord-312001-8p7scli8	122	15	central	central	JJ
cord-312001-8p7scli8	122	16	DEAD	DEAD	NNP
cord-312001-8p7scli8	122	17	-	-	HYPH
cord-312001-8p7scli8	122	18	box	box	NN
cord-312001-8p7scli8	122	19	helicase	helicase	NNP
cord-312001-8p7scli8	122	20	/	/	SYM
cord-312001-8p7scli8	122	21	ATPase	ATPase	NNP
cord-312001-8p7scli8	122	22	domain	domain	NN
cord-312001-8p7scli8	122	23	and	and	CC
cord-312001-8p7scli8	122	24	a	a	DT
cord-312001-8p7scli8	122	25	C	c	NN
cord-312001-8p7scli8	122	26	-	-	HYPH
cord-312001-8p7scli8	122	27	terminal	terminal	NN
cord-312001-8p7scli8	122	28	regulatory	regulatory	JJ
cord-312001-8p7scli8	122	29	domain	domain	NN
cord-312001-8p7scli8	122	30	(	(	-LRB-
cord-312001-8p7scli8	122	31	CTD	CTD	NNP
cord-312001-8p7scli8	122	32	)	)	-RRB-
cord-312001-8p7scli8	122	33	essential	essential	JJ
cord-312001-8p7scli8	122	34	for	for	IN
cord-312001-8p7scli8	122	35	RNA	RNA	NNP
cord-312001-8p7scli8	122	36	recognition	recognition	NN
cord-312001-8p7scli8	122	37	and	and	CC
cord-312001-8p7scli8	122	38	autorepression	autorepression	NN
cord-312001-8p7scli8	122	39	in	in	IN
cord-312001-8p7scli8	122	40	the	the	DT
cord-312001-8p7scli8	122	41	absence	absence	NN
cord-312001-8p7scli8	122	42	of	of	IN
cord-312001-8p7scli8	122	43	RNA	RNA	NNP
cord-312001-8p7scli8	122	44	ligands	ligand	NNS
cord-312001-8p7scli8	122	45	.	.	.
cord-312001-8p7scli8	123	1	With	with	IN
cord-312001-8p7scli8	123	2	the	the	DT
cord-312001-8p7scli8	123	3	exception	exception	NN
cord-312001-8p7scli8	123	4	of	of	IN
cord-312001-8p7scli8	123	5	LGP2	LGP2	NNP
cord-312001-8p7scli8	123	6	,	,	,
cord-312001-8p7scli8	123	7	RLRs	RLRs	NNP
cord-312001-8p7scli8	123	8	also	also	RB
cord-312001-8p7scli8	123	9	possess	possess	VBP
cord-312001-8p7scli8	123	10	two	two	CD
cord-312001-8p7scli8	123	11	N	n	CD
cord-312001-8p7scli8	123	12	-	-	HYPH
cord-312001-8p7scli8	123	13	terminal	terminal	JJ
cord-312001-8p7scli8	123	14	caspase	caspase	NN
cord-312001-8p7scli8	123	15	activation	activation	NN
cord-312001-8p7scli8	123	16	and	and	CC
cord-312001-8p7scli8	123	17	recruitment	recruitment	NN
cord-312001-8p7scli8	123	18	domains	domain	NNS
cord-312001-8p7scli8	123	19	(	(	-LRB-
cord-312001-8p7scli8	123	20	CARDs	card	NNS
cord-312001-8p7scli8	123	21	)	)	-RRB-
cord-312001-8p7scli8	123	22	.	.	.
cord-312001-8p7scli8	124	1	Upon	upon	IN
cord-312001-8p7scli8	124	2	RNA	RNA	NNP
cord-312001-8p7scli8	124	3	binding	bind	VBG
cord-312001-8p7scli8	124	4	RIG	rig	NN
cord-312001-8p7scli8	124	5	-	-	:
cord-312001-8p7scli8	124	6	I	-PRON-	PRP
cord-312001-8p7scli8	124	7	is	be	VBZ
cord-312001-8p7scli8	124	8	remodeled	remodel	VBN
cord-312001-8p7scli8	124	9	into	into	IN
cord-312001-8p7scli8	124	10	an	an	DT
cord-312001-8p7scli8	124	11	active	active	JJ
cord-312001-8p7scli8	124	12	conformation	conformation	NN
cord-312001-8p7scli8	124	13	in	in	IN
cord-312001-8p7scli8	124	14	which	which	WDT
cord-312001-8p7scli8	124	15	the	the	DT
cord-312001-8p7scli8	124	16	CTD	CTD	NNP
cord-312001-8p7scli8	124	17	and	and	CC
cord-312001-8p7scli8	124	18	helicase	helicase	NN
cord-312001-8p7scli8	124	19	domains	domain	NNS
cord-312001-8p7scli8	124	20	organize	organize	VBP
cord-312001-8p7scli8	124	21	into	into	IN
cord-312001-8p7scli8	124	22	a	a	DT
cord-312001-8p7scli8	124	23	ring	ring	NN
cord-312001-8p7scli8	124	24	around	around	IN
cord-312001-8p7scli8	124	25	the	the	DT
cord-312001-8p7scli8	124	26	RNA	RNA	NNP
cord-312001-8p7scli8	124	27	ligand	ligand	NN
cord-312001-8p7scli8	124	28	and	and	CC
cord-312001-8p7scli8	124	29	the	the	DT
cord-312001-8p7scli8	124	30	CARD	card	NN
cord-312001-8p7scli8	124	31	domains	domain	NNS
cord-312001-8p7scli8	124	32	are	be	VBP
cord-312001-8p7scli8	124	33	exposed	expose	VBN
cord-312001-8p7scli8	124	34	[	[	-LRB-
cord-312001-8p7scli8	124	35	84	84	CD
cord-312001-8p7scli8	124	36	,	,	,
cord-312001-8p7scli8	124	37	85	85	CD
cord-312001-8p7scli8	124	38	]	]	-RRB-
cord-312001-8p7scli8	124	39	which	which	WDT
cord-312001-8p7scli8	124	40	facilitate	facilitate	VBP
cord-312001-8p7scli8	124	41	their	-PRON-	PRP$
cord-312001-8p7scli8	124	42	interactions	interaction	NNS
cord-312001-8p7scli8	124	43	with	with	IN
cord-312001-8p7scli8	124	44	other	other	JJ
cord-312001-8p7scli8	124	45	CARD	card	NN
cord-312001-8p7scli8	124	46	domains	domain	NNS
cord-312001-8p7scli8	124	47	resulting	result	VBG
cord-312001-8p7scli8	124	48	in	in	IN
cord-312001-8p7scli8	124	49	RIG	rig	NN
cord-312001-8p7scli8	124	50	-	-	:
cord-312001-8p7scli8	124	51	I	-PRON-	PRP
cord-312001-8p7scli8	124	52	tetramers	tetramer	NNS
cord-312001-8p7scli8	124	53	.	.	.
cord-312001-8p7scli8	125	1	Although	although	IN
cord-312001-8p7scli8	125	2	RIG	rig	NN
cord-312001-8p7scli8	125	3	-	-	:
cord-312001-8p7scli8	125	4	I	I	NNP
cord-312001-8p7scli8	125	5	and	and	CC
cord-312001-8p7scli8	125	6	MDA5	MDA5	NNP
cord-312001-8p7scli8	125	7	share	share	VBP
cord-312001-8p7scli8	125	8	similar	similar	JJ
cord-312001-8p7scli8	125	9	domain	domain	NN
cord-312001-8p7scli8	125	10	architectures	architecture	NNS
cord-312001-8p7scli8	125	11	,	,	,
cord-312001-8p7scli8	125	12	MDA5	MDA5	NNP
cord-312001-8p7scli8	125	13	seems	seem	VBZ
cord-312001-8p7scli8	125	14	to	to	TO
cord-312001-8p7scli8	125	15	prefer	prefer	VB
cord-312001-8p7scli8	125	16	longer	long	RBR
cord-312001-8p7scli8	125	17	dsRNA	dsRNA	NNS
cord-312001-8p7scli8	125	18	,	,	,
cord-312001-8p7scli8	125	19	assembling	assemble	VBG
cord-312001-8p7scli8	125	20	along	along	IN
cord-312001-8p7scli8	125	21	these	these	DT
cord-312001-8p7scli8	125	22	molecules	molecule	NNS
cord-312001-8p7scli8	125	23	to	to	TO
cord-312001-8p7scli8	125	24	form	form	VB
cord-312001-8p7scli8	125	25	helical	helical	JJ
cord-312001-8p7scli8	125	26	,	,	,
cord-312001-8p7scli8	125	27	filamentous	filamentous	JJ
cord-312001-8p7scli8	125	28	oligomers	oligomer	NNS
cord-312001-8p7scli8	125	29	[	[	-LRB-
cord-312001-8p7scli8	125	30	86	86	CD
cord-312001-8p7scli8	125	31	,	,	,
cord-312001-8p7scli8	125	32	87	87	CD
cord-312001-8p7scli8	125	33	]	]	-RRB-
cord-312001-8p7scli8	125	34	.	.	.
cord-312001-8p7scli8	126	1	A	a	DT
cord-312001-8p7scli8	126	2	poly	poly	JJ
cord-312001-8p7scli8	126	3	-	-	HYPH
cord-312001-8p7scli8	126	4	ubiquitination	ubiquitination	JJ
cord-312001-8p7scli8	126	5	reaction	reaction	NN
cord-312001-8p7scli8	126	6	by	by	IN
cord-312001-8p7scli8	126	7	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	126	8	ligases	ligase	NNS
cord-312001-8p7scli8	126	9	like	like	IN
cord-312001-8p7scli8	126	10	Riplet	Riplet	NNP
cord-312001-8p7scli8	126	11	and	and	CC
cord-312001-8p7scli8	126	12	TRIM25	TRIM25	NNP
cord-312001-8p7scli8	126	13	(	(	-LRB-
cord-312001-8p7scli8	126	14	tripartite	tripartite	JJ
cord-312001-8p7scli8	126	15	motif	motif	NN
cord-312001-8p7scli8	126	16	-	-	:
cord-312001-8p7scli8	126	17	containing	contain	VBG
cord-312001-8p7scli8	126	18	25	25	CD
cord-312001-8p7scli8	126	19	)	)	-RRB-
cord-312001-8p7scli8	126	20	,	,	,
cord-312001-8p7scli8	126	21	is	be	VBZ
cord-312001-8p7scli8	126	22	thought	think	VBN
cord-312001-8p7scli8	126	23	to	to	TO
cord-312001-8p7scli8	126	24	enhance	enhance	VB
cord-312001-8p7scli8	126	25	RIG	rig	NN
cord-312001-8p7scli8	126	26	-	-	:
cord-312001-8p7scli8	126	27	I	I	NNP
cord-312001-8p7scli8	126	28	and	and	CC
cord-312001-8p7scli8	126	29	MDA5	mda5	JJ
cord-312001-8p7scli8	126	30	oligomerization	oligomerization	NN
cord-312001-8p7scli8	126	31	and	and	CC
cord-312001-8p7scli8	126	32	activation	activation	NN
cord-312001-8p7scli8	126	33	[	[	-LRB-
cord-312001-8p7scli8	126	34	88	88	CD
cord-312001-8p7scli8	126	35	]	]	-RRB-
cord-312001-8p7scli8	127	1	[	[	-LRB-
cord-312001-8p7scli8	127	2	89	89	CD
cord-312001-8p7scli8	127	3	]	]	-RRB-
cord-312001-8p7scli8	127	4	[	[	-LRB-
cord-312001-8p7scli8	127	5	90	90	CD
cord-312001-8p7scli8	127	6	]	]	-RRB-
cord-312001-8p7scli8	127	7	[	[	-LRB-
cord-312001-8p7scli8	127	8	91	91	CD
cord-312001-8p7scli8	127	9	]	]	-RRB-
cord-312001-8p7scli8	127	10	.	.	.
cord-312001-8p7scli8	128	1	RIG	rig	NN
cord-312001-8p7scli8	128	2	-	-	:
cord-312001-8p7scli8	128	3	I	I	NNP
cord-312001-8p7scli8	128	4	and	and	CC
cord-312001-8p7scli8	128	5	MDA5	mda5	JJ
cord-312001-8p7scli8	128	6	oligomers	oligomer	NNS
cord-312001-8p7scli8	128	7	then	then	RB
cord-312001-8p7scli8	128	8	serve	serve	VBP
cord-312001-8p7scli8	128	9	as	as	IN
cord-312001-8p7scli8	128	10	a	a	DT
cord-312001-8p7scli8	128	11	scaffold	scaffold	NN
cord-312001-8p7scli8	128	12	for	for	IN
cord-312001-8p7scli8	128	13	binding	bind	VBG
cord-312001-8p7scli8	128	14	to	to	IN
cord-312001-8p7scli8	128	15	the	the	DT
cord-312001-8p7scli8	128	16	adaptor	adaptor	NN
cord-312001-8p7scli8	128	17	protein	protein	NN
cord-312001-8p7scli8	128	18	MAVS	MAVS	NNP
cord-312001-8p7scli8	128	19	(	(	-LRB-
cord-312001-8p7scli8	128	20	mitochondrial	mitochondrial	JJ
cord-312001-8p7scli8	128	21	antiviral	antiviral	JJ
cord-312001-8p7scli8	128	22	signaling	signal	VBG
cord-312001-8p7scli8	128	23	protein	protein	NN
cord-312001-8p7scli8	128	24	,	,	,
cord-312001-8p7scli8	128	25	also	also	RB
cord-312001-8p7scli8	128	26	known	know	VBN
cord-312001-8p7scli8	128	27	as	as	IN
cord-312001-8p7scli8	128	28	IPS-1	IPS-1	NNP
cord-312001-8p7scli8	128	29	,	,	,
cord-312001-8p7scli8	128	30	VISA	VISA	NNP
cord-312001-8p7scli8	128	31	,	,	,
cord-312001-8p7scli8	128	32	and	and	CC
cord-312001-8p7scli8	128	33	CARDIF	CARDIF	NNP
cord-312001-8p7scli8	128	34	)	)	-RRB-
cord-312001-8p7scli8	128	35	[	[	-LRB-
cord-312001-8p7scli8	128	36	92	92	CD
cord-312001-8p7scli8	128	37	]	]	-RRB-
cord-312001-8p7scli8	128	38	[	[	-LRB-
cord-312001-8p7scli8	128	39	93	93	CD
cord-312001-8p7scli8	128	40	]	]	-RRB-
cord-312001-8p7scli8	128	41	[	[	-LRB-
cord-312001-8p7scli8	128	42	94	94	CD
cord-312001-8p7scli8	128	43	]	]	-RRB-
cord-312001-8p7scli8	128	44	.	.	.
cord-312001-8p7scli8	129	1	MAVS	MAVS	NNP
cord-312001-8p7scli8	129	2	has	have	VBZ
cord-312001-8p7scli8	129	3	been	be	VBN
cord-312001-8p7scli8	129	4	shown	show	VBN
cord-312001-8p7scli8	129	5	to	to	TO
cord-312001-8p7scli8	129	6	be	be	VB
cord-312001-8p7scli8	129	7	critical	critical	JJ
cord-312001-8p7scli8	129	8	for	for	IN
cord-312001-8p7scli8	129	9	mounting	mount	VBG
cord-312001-8p7scli8	129	10	an	an	DT
cord-312001-8p7scli8	129	11	efficient	efficient	JJ
cord-312001-8p7scli8	129	12	immune	immune	JJ
cord-312001-8p7scli8	129	13	response	response	NN
cord-312001-8p7scli8	129	14	to	to	IN
cord-312001-8p7scli8	129	15	infection	infection	NN
cord-312001-8p7scli8	129	16	by	by	IN
cord-312001-8p7scli8	129	17	several	several	JJ
cord-312001-8p7scli8	129	18	RNA	RNA	NNP
cord-312001-8p7scli8	129	19	viruses	virus	NNS
cord-312001-8p7scli8	129	20	[	[	-LRB-
cord-312001-8p7scli8	129	21	95	95	CD
cord-312001-8p7scli8	129	22	]	]	-RRB-
cord-312001-8p7scli8	129	23	.	.	.
cord-312001-8p7scli8	130	1	Its	-PRON-	PRP$
cord-312001-8p7scli8	130	2	C	c	NN
cord-312001-8p7scli8	130	3	-	-	HYPH
cord-312001-8p7scli8	130	4	terminal	terminal	NN
cord-312001-8p7scli8	130	5	transmembrane	transmembrane	NN
cord-312001-8p7scli8	130	6	domain	domain	NN
cord-312001-8p7scli8	130	7	is	be	VBZ
cord-312001-8p7scli8	130	8	inserted	insert	VBN
cord-312001-8p7scli8	130	9	into	into	IN
cord-312001-8p7scli8	130	10	the	the	DT
cord-312001-8p7scli8	130	11	outer	outer	JJ
cord-312001-8p7scli8	130	12	mitochondrial	mitochondrial	NN
cord-312001-8p7scli8	130	13	membrane	membrane	NN
cord-312001-8p7scli8	130	14	[	[	-LRB-
cord-312001-8p7scli8	130	15	96	96	CD
cord-312001-8p7scli8	130	16	]	]	-RRB-
cord-312001-8p7scli8	130	17	,	,	,
cord-312001-8p7scli8	130	18	whereas	whereas	IN
cord-312001-8p7scli8	130	19	its	-PRON-	PRP$
cord-312001-8p7scli8	130	20	N	n	CD
cord-312001-8p7scli8	130	21	-	-	HYPH
cord-312001-8p7scli8	130	22	terminal	terminal	JJ
cord-312001-8p7scli8	130	23	CARD	card	NN
cord-312001-8p7scli8	130	24	domain	domain	NN
cord-312001-8p7scli8	130	25	mediates	mediate	VBZ
cord-312001-8p7scli8	130	26	its	-PRON-	PRP$
cord-312001-8p7scli8	130	27	aggregation	aggregation	NN
cord-312001-8p7scli8	130	28	on	on	IN
cord-312001-8p7scli8	130	29	the	the	DT
cord-312001-8p7scli8	130	30	mitochondrial	mitochondrial	NN
cord-312001-8p7scli8	130	31	surface	surface	NN
cord-312001-8p7scli8	130	32	by	by	IN
cord-312001-8p7scli8	130	33	interacting	interact	VBG
cord-312001-8p7scli8	130	34	with	with	IN
cord-312001-8p7scli8	130	35	the	the	DT
cord-312001-8p7scli8	130	36	tandem	tandem	NN
cord-312001-8p7scli8	130	37	CARDs	card	NNS
cord-312001-8p7scli8	130	38	of	of	IN
cord-312001-8p7scli8	130	39	RIG	rig	NN
cord-312001-8p7scli8	130	40	-	-	:
cord-312001-8p7scli8	130	41	I	I	NNP
cord-312001-8p7scli8	130	42	or	or	CC
cord-312001-8p7scli8	130	43	MDA5	mda5	JJ
cord-312001-8p7scli8	130	44	oligomers	oligomer	NNS
cord-312001-8p7scli8	130	45	[	[	-LRB-
cord-312001-8p7scli8	130	46	97	97	CD
cord-312001-8p7scli8	130	47	,	,	,
cord-312001-8p7scli8	130	48	98	98	CD
cord-312001-8p7scli8	130	49	]	]	-RRB-
cord-312001-8p7scli8	130	50	.	.	.
cord-312001-8p7scli8	131	1	MAVS	MAVS	NNP
cord-312001-8p7scli8	131	2	aggregates	aggregate	NNS
cord-312001-8p7scli8	131	3	then	then	RB
cord-312001-8p7scli8	131	4	recruit	recruit	VBP
cord-312001-8p7scli8	131	5	several	several	JJ
cord-312001-8p7scli8	131	6	E3	e3	NN
cord-312001-8p7scli8	131	7	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	131	8	ligases	ligase	NNS
cord-312001-8p7scli8	131	9	including	include	VBG
cord-312001-8p7scli8	131	10	TRAF2	TRAF2	NNP
cord-312001-8p7scli8	131	11	,	,	,
cord-312001-8p7scli8	131	12	TRAF5	TRAF5	NNP
cord-312001-8p7scli8	131	13	and	and	CC
cord-312001-8p7scli8	131	14	TRAF6	traf6	NN
cord-312001-8p7scli8	131	15	.	.	.
cord-312001-8p7scli8	132	1	Although	although	IN
cord-312001-8p7scli8	132	2	TRAF	TRAF	NNP
cord-312001-8p7scli8	132	3	-	-	HYPH
cord-312001-8p7scli8	132	4	mediated	mediate	VBN
cord-312001-8p7scli8	132	5	ubiquitination	ubiquitination	NN
cord-312001-8p7scli8	132	6	is	be	VBZ
cord-312001-8p7scli8	132	7	essential	essential	JJ
cord-312001-8p7scli8	132	8	to	to	TO
cord-312001-8p7scli8	132	9	activate	activate	VB
cord-312001-8p7scli8	132	10	MAVS	MAVS	NNP
cord-312001-8p7scli8	132	11	downstream	downstream	JJ
cord-312001-8p7scli8	132	12	signaling	signal	VBG
cord-312001-8p7scli8	132	13	,	,	,
cord-312001-8p7scli8	132	14	the	the	DT
cord-312001-8p7scli8	132	15	ubiquitination	ubiquitination	JJ
cord-312001-8p7scli8	132	16	targets	target	NNS
cord-312001-8p7scli8	132	17	of	of	IN
cord-312001-8p7scli8	132	18	TRAF	TRAF	NNP
cord-312001-8p7scli8	132	19	remain	remain	VBP
cord-312001-8p7scli8	132	20	unknown	unknown	JJ
cord-312001-8p7scli8	132	21	[	[	-LRB-
cord-312001-8p7scli8	132	22	99	99	CD
cord-312001-8p7scli8	132	23	]	]	-RRB-
cord-312001-8p7scli8	132	24	.	.	.
cord-312001-8p7scli8	133	1	Subsequently	subsequently	RB
cord-312001-8p7scli8	133	2	,	,	,
cord-312001-8p7scli8	133	3	the	the	DT
cord-312001-8p7scli8	133	4	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	133	5	sensor	sensor	NN
cord-312001-8p7scli8	133	6	NEMO	NEMO	NNP
cord-312001-8p7scli8	133	7	(	(	-LRB-
cord-312001-8p7scli8	133	8	NF	nf	NN
cord-312001-8p7scli8	133	9	-	-	HYPH
cord-312001-8p7scli8	133	10	κB	κb	CD
cord-312001-8p7scli8	133	11	essential	essential	JJ
cord-312001-8p7scli8	133	12	modulator	modulator	NN
cord-312001-8p7scli8	133	13	,	,	,
cord-312001-8p7scli8	133	14	also	also	RB
cord-312001-8p7scli8	133	15	known	know	VBN
cord-312001-8p7scli8	133	16	as	as	IN
cord-312001-8p7scli8	133	17	IKKγ	IKKγ	NNS
cord-312001-8p7scli8	133	18	)	)	-RRB-
cord-312001-8p7scli8	133	19	[	[	-LRB-
cord-312001-8p7scli8	133	20	100	100	CD
cord-312001-8p7scli8	133	21	,	,	,
cord-312001-8p7scli8	133	22	101	101	CD
cord-312001-8p7scli8	133	23	]	]	-RRB-
cord-312001-8p7scli8	133	24	is	be	VBZ
cord-312001-8p7scli8	133	25	then	then	RB
cord-312001-8p7scli8	133	26	recruited	recruit	VBN
cord-312001-8p7scli8	133	27	to	to	IN
cord-312001-8p7scli8	133	28	the	the	DT
cord-312001-8p7scli8	133	29	MAVS	MAVS	NNPS
cord-312001-8p7scli8	133	30	/	/	SYM
cord-312001-8p7scli8	133	31	TRAFs	TRAFs	NNP
cord-312001-8p7scli8	133	32	complex	complex	JJ
cord-312001-8p7scli8	133	33	,	,	,
cord-312001-8p7scli8	133	34	which	which	WDT
cord-312001-8p7scli8	133	35	in	in	IN
cord-312001-8p7scli8	133	36	turn	turn	NN
cord-312001-8p7scli8	133	37	recruits	recruit	VBZ
cord-312001-8p7scli8	133	38	IKK	IKK	NNP
cord-312001-8p7scli8	133	39	and	and	CC
cord-312001-8p7scli8	133	40	TBK1	TBK1	NNP
cord-312001-8p7scli8	133	41	to	to	IN
cord-312001-8p7scli8	133	42	the	the	DT
cord-312001-8p7scli8	133	43	MAVS	MAVS	NNP
cord-312001-8p7scli8	133	44	complex	complex	JJ
cord-312001-8p7scli8	133	45	leading	lead	VBG
cord-312001-8p7scli8	133	46	to	to	IN
cord-312001-8p7scli8	133	47	activation	activation	NN
cord-312001-8p7scli8	133	48	of	of	IN
cord-312001-8p7scli8	133	49	NF	NF	NNP
cord-312001-8p7scli8	133	50	-	-	HYPH
cord-312001-8p7scli8	133	51	kB	kB	NNP
cord-312001-8p7scli8	133	52	and	and	CC
cord-312001-8p7scli8	133	53	IRF3	IRF3	NNP
cord-312001-8p7scli8	133	54	and	and	CC
cord-312001-8p7scli8	133	55	their	-PRON-	PRP$
cord-312001-8p7scli8	133	56	translocation	translocation	NN
cord-312001-8p7scli8	133	57	to	to	IN
cord-312001-8p7scli8	133	58	the	the	DT
cord-312001-8p7scli8	133	59	nucleus	nucleus	NN
cord-312001-8p7scli8	133	60	to	to	TO
cord-312001-8p7scli8	133	61	induce	induce	VB
cord-312001-8p7scli8	133	62	the	the	DT
cord-312001-8p7scli8	133	63	transcription	transcription	NN
cord-312001-8p7scli8	133	64	of	of	IN
cord-312001-8p7scli8	133	65	antiviral	antiviral	JJ
cord-312001-8p7scli8	133	66	genes	gene	NNS
cord-312001-8p7scli8	133	67	[	[	-LRB-
cord-312001-8p7scli8	133	68	99	99	CD
cord-312001-8p7scli8	133	69	]	]	-RRB-
cord-312001-8p7scli8	133	70	[	[	-LRB-
cord-312001-8p7scli8	133	71	100	100	CD
cord-312001-8p7scli8	133	72	]	]	-RRB-
cord-312001-8p7scli8	133	73	[	[	-LRB-
cord-312001-8p7scli8	133	74	101	101	CD
cord-312001-8p7scli8	133	75	]	]	-RRB-
cord-312001-8p7scli8	133	76	[	[	-LRB-
cord-312001-8p7scli8	133	77	102	102	CD
cord-312001-8p7scli8	133	78	]	]	-RRB-
cord-312001-8p7scli8	133	79	(	(	-LRB-
cord-312001-8p7scli8	133	80	Figure	figure	NN
cord-312001-8p7scli8	133	81	1	1	CD
cord-312001-8p7scli8	133	82	)	)	-RRB-
cord-312001-8p7scli8	133	83	.	.	.
cord-312001-8p7scli8	134	1	After	after	IN
cord-312001-8p7scli8	134	2	TRIF	TRIF	NNP
cord-312001-8p7scli8	134	3	and	and	CC
cord-312001-8p7scli8	134	4	MAVS	MAVS	NNPS
cord-312001-8p7scli8	134	5	were	be	VBD
cord-312001-8p7scli8	134	6	discovered	discover	VBN
cord-312001-8p7scli8	134	7	,	,	,
cord-312001-8p7scli8	134	8	STING	STING	NNP
cord-312001-8p7scli8	134	9	was	be	VBD
cord-312001-8p7scli8	134	10	identified	identify	VBN
cord-312001-8p7scli8	134	11	as	as	IN
cord-312001-8p7scli8	134	12	a	a	DT
cord-312001-8p7scli8	134	13	third	third	JJ
cord-312001-8p7scli8	134	14	adaptor	adaptor	NN
cord-312001-8p7scli8	134	15	protein	protein	NN
cord-312001-8p7scli8	134	16	that	that	WDT
cord-312001-8p7scli8	134	17	is	be	VBZ
cord-312001-8p7scli8	134	18	also	also	RB
cord-312001-8p7scli8	134	19	able	able	JJ
cord-312001-8p7scli8	134	20	to	to	TO
cord-312001-8p7scli8	134	21	activate	activate	VB
cord-312001-8p7scli8	134	22	IRF3	IRF3	NNP
cord-312001-8p7scli8	134	23	and	and	CC
cord-312001-8p7scli8	134	24	IFN	IFN	NNP
cord-312001-8p7scli8	134	25	production	production	NN
cord-312001-8p7scli8	134	26	[	[	-LRB-
cord-312001-8p7scli8	134	27	103	103	CD
cord-312001-8p7scli8	134	28	,	,	,
cord-312001-8p7scli8	134	29	104	104	CD
cord-312001-8p7scli8	134	30	]	]	-RRB-
cord-312001-8p7scli8	134	31	.	.	.
cord-312001-8p7scli8	135	1	STING	STING	NNP
cord-312001-8p7scli8	135	2	is	be	VBZ
cord-312001-8p7scli8	135	3	an	an	DT
cord-312001-8p7scli8	135	4	endoplasmic	endoplasmic	NN
cord-312001-8p7scli8	135	5	reticulum	reticulum	NN
cord-312001-8p7scli8	135	6	(	(	-LRB-
cord-312001-8p7scli8	135	7	ER	ER	NNP
cord-312001-8p7scli8	135	8	)	)	-RRB-
cord-312001-8p7scli8	135	9	resident	resident	NN
cord-312001-8p7scli8	135	10	membrane	membrane	NN
cord-312001-8p7scli8	135	11	protein	protein	NN
cord-312001-8p7scli8	135	12	with	with	IN
cord-312001-8p7scli8	135	13	cytoplasmic	cytoplasmic	JJ
cord-312001-8p7scli8	135	14	C	C	NNP
cord-312001-8p7scli8	135	15	-	-	HYPH
cord-312001-8p7scli8	135	16	and	and	CC
cord-312001-8p7scli8	135	17	N	N	NNP
cord-312001-8p7scli8	135	18	-	-	HYPH
cord-312001-8p7scli8	135	19	termini	termini	NNP
cord-312001-8p7scli8	135	20	.	.	.
cord-312001-8p7scli8	136	1	STING	STING	NNP
cord-312001-8p7scli8	136	2	has	have	VBZ
cord-312001-8p7scli8	136	3	been	be	VBN
cord-312001-8p7scli8	136	4	shown	show	VBN
cord-312001-8p7scli8	136	5	to	to	TO
cord-312001-8p7scli8	136	6	be	be	VB
cord-312001-8p7scli8	136	7	essential	essential	JJ
cord-312001-8p7scli8	136	8	for	for	IN
cord-312001-8p7scli8	136	9	DNA	dna	NN
cord-312001-8p7scli8	136	10	-	-	HYPH
cord-312001-8p7scli8	136	11	mediated	mediate	VBN
cord-312001-8p7scli8	136	12	IFN	IFN	NNP
cord-312001-8p7scli8	136	13	production	production	NN
cord-312001-8p7scli8	136	14	in	in	IN
cord-312001-8p7scli8	136	15	different	different	JJ
cord-312001-8p7scli8	136	16	tissues	tissue	NNS
cord-312001-8p7scli8	136	17	,	,	,
cord-312001-8p7scli8	136	18	for	for	IN
cord-312001-8p7scli8	136	19	example	example	NN
cord-312001-8p7scli8	136	20	,	,	,
cord-312001-8p7scli8	136	21	it	-PRON-	PRP
cord-312001-8p7scli8	136	22	is	be	VBZ
cord-312001-8p7scli8	136	23	crucial	crucial	JJ
cord-312001-8p7scli8	136	24	for	for	IN
cord-312001-8p7scli8	136	25	host	host	NN
cord-312001-8p7scli8	136	26	defense	defense	NN
cord-312001-8p7scli8	136	27	against	against	IN
cord-312001-8p7scli8	136	28	the	the	DT
cord-312001-8p7scli8	136	29	DNA	dna	NN
cord-312001-8p7scli8	136	30	virus	virus	NN
cord-312001-8p7scli8	136	31	HSV-1	HSV-1	NNP
cord-312001-8p7scli8	136	32	[	[	-LRB-
cord-312001-8p7scli8	136	33	105	105	CD
cord-312001-8p7scli8	136	34	]	]	-RRB-
cord-312001-8p7scli8	136	35	.	.	.
cord-312001-8p7scli8	137	1	STING	STING	NNP
cord-312001-8p7scli8	137	2	has	have	VBZ
cord-312001-8p7scli8	137	3	also	also	RB
cord-312001-8p7scli8	137	4	been	be	VBN
cord-312001-8p7scli8	137	5	shown	show	VBN
cord-312001-8p7scli8	137	6	to	to	TO
cord-312001-8p7scli8	137	7	sense	sense	VB
cord-312001-8p7scli8	137	8	cyclic	cyclic	JJ
cord-312001-8p7scli8	137	9	dinucleotides	dinucleotide	NNS
cord-312001-8p7scli8	137	10	(	(	-LRB-
cord-312001-8p7scli8	137	11	CDNs	CDNs	NNP
cord-312001-8p7scli8	137	12	)	)	-RRB-
cord-312001-8p7scli8	137	13	,	,	,
cord-312001-8p7scli8	137	14	which	which	WDT
cord-312001-8p7scli8	137	15	are	be	VBP
cord-312001-8p7scli8	137	16	the	the	DT
cord-312001-8p7scli8	137	17	second	second	JJ
cord-312001-8p7scli8	137	18	messengers	messenger	NNS
cord-312001-8p7scli8	137	19	known	know	VBN
cord-312001-8p7scli8	137	20	to	to	TO
cord-312001-8p7scli8	137	21	be	be	VB
cord-312001-8p7scli8	137	22	produced	produce	VBN
cord-312001-8p7scli8	137	23	by	by	IN
cord-312001-8p7scli8	137	24	bacteria	bacteria	NNS
cord-312001-8p7scli8	137	25	such	such	JJ
cord-312001-8p7scli8	137	26	as	as	IN
cord-312001-8p7scli8	137	27	Listeria	Listeria	NNP
cord-312001-8p7scli8	137	28	monocytogenes	monocytogenes	NNP
cord-312001-8p7scli8	137	29	[	[	-LRB-
cord-312001-8p7scli8	137	30	106	106	CD
cord-312001-8p7scli8	137	31	]	]	-RRB-
cord-312001-8p7scli8	137	32	[	[	-LRB-
cord-312001-8p7scli8	137	33	107	107	CD
cord-312001-8p7scli8	137	34	]	]	-RRB-
cord-312001-8p7scli8	137	35	[	[	-LRB-
cord-312001-8p7scli8	137	36	108	108	CD
cord-312001-8p7scli8	137	37	]	]	-RRB-
cord-312001-8p7scli8	137	38	[	[	-LRB-
cord-312001-8p7scli8	137	39	109	109	CD
cord-312001-8p7scli8	137	40	]	]	-RRB-
cord-312001-8p7scli8	137	41	.	.	.
cord-312001-8p7scli8	138	1	Although	although	IN
cord-312001-8p7scli8	138	2	it	-PRON-	PRP
cord-312001-8p7scli8	138	3	can	can	MD
cord-312001-8p7scli8	138	4	bind	bind	VB
cord-312001-8p7scli8	138	5	bacterial	bacterial	JJ
cord-312001-8p7scli8	138	6	CDNs	cdn	NNS
cord-312001-8p7scli8	138	7	,	,	,
cord-312001-8p7scli8	138	8	STING	STING	NNP
cord-312001-8p7scli8	138	9	is	be	VBZ
cord-312001-8p7scli8	138	10	unable	unable	JJ
cord-312001-8p7scli8	138	11	to	to	TO
cord-312001-8p7scli8	138	12	bind	bind	VB
cord-312001-8p7scli8	138	13	DNA	DNA	NNP
cord-312001-8p7scli8	138	14	and	and	CC
cord-312001-8p7scli8	138	15	relies	rely	VBZ
cord-312001-8p7scli8	138	16	on	on	IN
cord-312001-8p7scli8	138	17	an	an	DT
cord-312001-8p7scli8	138	18	upstream	upstream	JJ
cord-312001-8p7scli8	138	19	sensor	sensor	NN
cord-312001-8p7scli8	138	20	,	,	,
cord-312001-8p7scli8	138	21	cGAS	cgas	JJ
cord-312001-8p7scli8	138	22	[	[	-LRB-
cord-312001-8p7scli8	138	23	43	43	CD
cord-312001-8p7scli8	138	24	]	]	-RRB-
cord-312001-8p7scli8	138	25	.	.	.
cord-312001-8p7scli8	139	1	cGAS	cGAS	NNP
cord-312001-8p7scli8	139	2	is	be	VBZ
cord-312001-8p7scli8	139	3	an	an	DT
cord-312001-8p7scli8	139	4	enzyme	enzyme	NN
cord-312001-8p7scli8	139	5	that	that	WDT
cord-312001-8p7scli8	139	6	contains	contain	VBZ
cord-312001-8p7scli8	139	7	a	a	DT
cord-312001-8p7scli8	139	8	nucleotidyltransferase	nucleotidyltransferase	NN
cord-312001-8p7scli8	139	9	(	(	-LRB-
cord-312001-8p7scli8	139	10	NTase	NTase	NNP
cord-312001-8p7scli8	139	11	)	)	-RRB-
cord-312001-8p7scli8	139	12	domain	domain	NN
cord-312001-8p7scli8	139	13	and	and	CC
cord-312001-8p7scli8	139	14	can	can	MD
cord-312001-8p7scli8	139	15	synthesize	synthesize	VB
cord-312001-8p7scli8	139	16	the	the	DT
cord-312001-8p7scli8	139	17	second	second	JJ
cord-312001-8p7scli8	139	18	messenger	messenger	NN
cord-312001-8p7scli8	139	19	2	2	CD
cord-312001-8p7scli8	139	20	3	3	CD
cord-312001-8p7scli8	139	21	-cyclic	-cyclic	NNP
cord-312001-8p7scli8	139	22	GMP	GMP	NNP
cord-312001-8p7scli8	139	23	-	-	HYPH
cord-312001-8p7scli8	139	24	AMP	AMP	NNP
cord-312001-8p7scli8	139	25	(	(	-LRB-
cord-312001-8p7scli8	139	26	cGAMP	cGAMP	NNP
cord-312001-8p7scli8	139	27	)	)	-RRB-
cord-312001-8p7scli8	139	28	from	from	IN
cord-312001-8p7scli8	139	29	ATP	ATP	NNP
cord-312001-8p7scli8	139	30	and	and	CC
cord-312001-8p7scli8	139	31	GTP	GTP	NNP
cord-312001-8p7scli8	139	32	upon	upon	IN
cord-312001-8p7scli8	139	33	DNA	dna	NN
cord-312001-8p7scli8	139	34	recognition	recognition	NN
cord-312001-8p7scli8	139	35	(	(	-LRB-
cord-312001-8p7scli8	139	36	Figure	figure	NN
cord-312001-8p7scli8	139	37	1	1	CD
cord-312001-8p7scli8	139	38	)	)	-RRB-
cord-312001-8p7scli8	139	39	.	.	.
cord-312001-8p7scli8	140	1	Loss	loss	NN
cord-312001-8p7scli8	140	2	of	of	IN
cord-312001-8p7scli8	140	3	cGAS	cgas	NN
cord-312001-8p7scli8	140	4	in	in	IN
cord-312001-8p7scli8	140	5	various	various	JJ
cord-312001-8p7scli8	140	6	cell	cell	NN
cord-312001-8p7scli8	140	7	lines	line	NNS
cord-312001-8p7scli8	140	8	and	and	CC
cord-312001-8p7scli8	140	9	also	also	RB
cord-312001-8p7scli8	140	10	in	in	IN
cord-312001-8p7scli8	140	11	vivo	vivo	NN
cord-312001-8p7scli8	140	12	results	result	NNS
cord-312001-8p7scli8	140	13	in	in	IN
cord-312001-8p7scli8	140	14	a	a	DT
cord-312001-8p7scli8	140	15	complete	complete	JJ
cord-312001-8p7scli8	140	16	loss	loss	NN
cord-312001-8p7scli8	140	17	of	of	IN
cord-312001-8p7scli8	140	18	type	type	NN
cord-312001-8p7scli8	141	1	I	-PRON-	PRP
cord-312001-8p7scli8	141	2	IFN	IFN	NNP
cord-312001-8p7scli8	141	3	induction	induction	NN
cord-312001-8p7scli8	141	4	upon	upon	IN
cord-312001-8p7scli8	141	5	DNA	dna	NN
cord-312001-8p7scli8	141	6	delivery	delivery	NN
cord-312001-8p7scli8	141	7	or	or	CC
cord-312001-8p7scli8	141	8	viral	viral	JJ
cord-312001-8p7scli8	141	9	infections	infection	NNS
cord-312001-8p7scli8	141	10	[	[	-LRB-
cord-312001-8p7scli8	141	11	110	110	CD
cord-312001-8p7scli8	141	12	,	,	,
cord-312001-8p7scli8	141	13	111	111	CD
cord-312001-8p7scli8	141	14	]	]	-RRB-
cord-312001-8p7scli8	141	15	.	.	.
cord-312001-8p7scli8	142	1	cGAS	cGAS	NNP
cord-312001-8p7scli8	142	2	preferentially	preferentially	RB
cord-312001-8p7scli8	142	3	binds	bind	VBZ
cord-312001-8p7scli8	142	4	longer	long	JJR
cord-312001-8p7scli8	142	5	DNA	dna	NN
cord-312001-8p7scli8	142	6	(	(	-LRB-
cord-312001-8p7scli8	142	7	>	>	NFP
cord-312001-8p7scli8	142	8	45	45	CD
cord-312001-8p7scli8	142	9	bp	bp	NNP
cord-312001-8p7scli8	142	10	)	)	-RRB-
cord-312001-8p7scli8	142	11	as	as	IN
cord-312001-8p7scli8	142	12	a	a	DT
cord-312001-8p7scli8	142	13	dimer	dimer	NN
cord-312001-8p7scli8	142	14	to	to	TO
cord-312001-8p7scli8	142	15	form	form	VB
cord-312001-8p7scli8	142	16	stable	stable	JJ
cord-312001-8p7scli8	142	17	protein	protein	NN
cord-312001-8p7scli8	142	18	-	-	HYPH
cord-312001-8p7scli8	142	19	DNA	dna	NN
cord-312001-8p7scli8	142	20	ladder	ladder	NN
cord-312001-8p7scli8	142	21	networks	network	NNS
cord-312001-8p7scli8	142	22	responsible	responsible	JJ
cord-312001-8p7scli8	142	23	for	for	IN
cord-312001-8p7scli8	142	24	strong	strong	JJ
cord-312001-8p7scli8	142	25	cGAMP	cGAMP	NNP
cord-312001-8p7scli8	142	26	production	production	NN
cord-312001-8p7scli8	142	27	[	[	-LRB-
cord-312001-8p7scli8	142	28	112	112	CD
cord-312001-8p7scli8	142	29	,	,	,
cord-312001-8p7scli8	142	30	113	113	CD
cord-312001-8p7scli8	142	31	]	]	-RRB-
cord-312001-8p7scli8	142	32	.	.	.
cord-312001-8p7scli8	143	1	A	a	DT
cord-312001-8p7scli8	143	2	unique	unique	JJ
cord-312001-8p7scli8	143	3	cGAMP	cGAMP	NNS
cord-312001-8p7scli8	143	4	isomer	isomer	NN
cord-312001-8p7scli8	143	5	termed	term	VBN
cord-312001-8p7scli8	143	6	2	2	CD
cord-312001-8p7scli8	143	7	3	3	CD
cord-312001-8p7scli8	143	8	-cGAMP	-cGAMP	NNPS
cord-312001-8p7scli8	143	9	with	with	IN
cord-312001-8p7scli8	143	10	particular	particular	JJ
cord-312001-8p7scli8	143	11	phosphodiester	phosphodiester	NN
cord-312001-8p7scli8	143	12	linkages	linkage	NNS
cord-312001-8p7scli8	144	1	is	be	VBZ
cord-312001-8p7scli8	144	2	produced	produce	VBN
cord-312001-8p7scli8	144	3	by	by	IN
cord-312001-8p7scli8	144	4	cGAS	cga	VBG
cord-312001-8p7scli8	144	5	[	[	-LRB-
cord-312001-8p7scli8	144	6	114	114	CD
cord-312001-8p7scli8	144	7	,	,	,
cord-312001-8p7scli8	144	8	115	115	CD
cord-312001-8p7scli8	144	9	]	]	-RRB-
cord-312001-8p7scli8	144	10	.	.	.
cord-312001-8p7scli8	145	1	2	2	CD
cord-312001-8p7scli8	145	2	3	3	CD
cord-312001-8p7scli8	145	3	-cGAMP	-cGAMP	NNPS
cord-312001-8p7scli8	145	4	is	be	VBZ
cord-312001-8p7scli8	145	5	a	a	DT
cord-312001-8p7scli8	145	6	potent	potent	JJ
cord-312001-8p7scli8	145	7	STING	sting	NN
cord-312001-8p7scli8	145	8	ligand	ligand	NN
cord-312001-8p7scli8	145	9	and	and	CC
cord-312001-8p7scli8	145	10	has	have	VBZ
cord-312001-8p7scli8	145	11	a	a	DT
cord-312001-8p7scli8	145	12	higher	high	JJR
cord-312001-8p7scli8	145	13	affinity	affinity	NN
cord-312001-8p7scli8	145	14	to	to	IN
cord-312001-8p7scli8	145	15	this	this	DT
cord-312001-8p7scli8	145	16	protein	protein	NN
cord-312001-8p7scli8	145	17	than	than	IN
cord-312001-8p7scli8	145	18	other	other	JJ
cord-312001-8p7scli8	145	19	cGAMP	cGAMP	NNS
cord-312001-8p7scli8	145	20	molecules	molecule	NNS
cord-312001-8p7scli8	145	21	containing	contain	VBG
cord-312001-8p7scli8	145	22	different	different	JJ
cord-312001-8p7scli8	145	23	phosphodiester	phosphodiester	NN
cord-312001-8p7scli8	145	24	linkages	linkage	NNS
cord-312001-8p7scli8	145	25	such	such	JJ
cord-312001-8p7scli8	145	26	as	as	IN
cord-312001-8p7scli8	145	27	2	2	CD
cord-312001-8p7scli8	145	28	2	2	CD
cord-312001-8p7scli8	145	29	-cGAMP	-cGAMP	NNPS
cord-312001-8p7scli8	145	30	,	,	,
cord-312001-8p7scli8	145	31	3	3	CD
cord-312001-8p7scli8	145	32	2	2	CD
cord-312001-8p7scli8	145	33	-cGAMP	-cGAMP	NNS
cord-312001-8p7scli8	145	34	or	or	CC
cord-312001-8p7scli8	145	35	bacterial	bacterial	JJ
cord-312001-8p7scli8	145	36	CDNs	cdns	XX
cord-312001-8p7scli8	145	37	[	[	-LRB-
cord-312001-8p7scli8	145	38	70	70	CD
cord-312001-8p7scli8	145	39	,	,	,
cord-312001-8p7scli8	145	40	115	115	CD
cord-312001-8p7scli8	145	41	]	]	-RRB-
cord-312001-8p7scli8	145	42	.	.	.
cord-312001-8p7scli8	146	1	Apart	apart	RB
cord-312001-8p7scli8	146	2	from	from	IN
cord-312001-8p7scli8	146	3	activating	activate	VBG
cord-312001-8p7scli8	146	4	STING	sting	NN
cord-312001-8p7scli8	146	5	in	in	IN
cord-312001-8p7scli8	146	6	the	the	DT
cord-312001-8p7scli8	146	7	cell	cell	NN
cord-312001-8p7scli8	146	8	where	where	WRB
cord-312001-8p7scli8	146	9	cGAS	cgas	NN
cord-312001-8p7scli8	146	10	initially	initially	RB
cord-312001-8p7scli8	146	11	detects	detect	VBZ
cord-312001-8p7scli8	146	12	viral	viral	JJ
cord-312001-8p7scli8	146	13	DNA	dna	NN
cord-312001-8p7scli8	146	14	,	,	,
cord-312001-8p7scli8	146	15	cGAMP	cGAMP	NNP
cord-312001-8p7scli8	146	16	second	second	JJ
cord-312001-8p7scli8	146	17	messengers	messenger	NNS
cord-312001-8p7scli8	146	18	can	can	MD
cord-312001-8p7scli8	146	19	also	also	RB
cord-312001-8p7scli8	146	20	travel	travel	VB
cord-312001-8p7scli8	146	21	to	to	IN
cord-312001-8p7scli8	146	22	neighboring	neighboring	NN
cord-312001-8p7scli8	146	23	cells	cell	NNS
cord-312001-8p7scli8	146	24	,	,	,
cord-312001-8p7scli8	146	25	through	through	IN
cord-312001-8p7scli8	146	26	gap	gap	NN
cord-312001-8p7scli8	146	27	-	-	HYPH
cord-312001-8p7scli8	146	28	junctions	junction	NNS
cord-312001-8p7scli8	146	29	[	[	-LRB-
cord-312001-8p7scli8	146	30	114	114	CD
cord-312001-8p7scli8	146	31	]	]	-RRB-
cord-312001-8p7scli8	146	32	or	or	CC
cord-312001-8p7scli8	146	33	after	after	IN
cord-312001-8p7scli8	146	34	being	be	VBG
cord-312001-8p7scli8	146	35	packaged	package	VBN
cord-312001-8p7scli8	146	36	in	in	IN
cord-312001-8p7scli8	146	37	newly	newly	RB
cord-312001-8p7scli8	146	38	formed	form	VBN
cord-312001-8p7scli8	146	39	virions	virion	NNS
cord-312001-8p7scli8	146	40	[	[	-LRB-
cord-312001-8p7scli8	146	41	116	116	CD
cord-312001-8p7scli8	146	42	,	,	,
cord-312001-8p7scli8	146	43	117	117	CD
cord-312001-8p7scli8	146	44	]	]	-RRB-
cord-312001-8p7scli8	146	45	.	.	.
cord-312001-8p7scli8	147	1	This	this	DT
cord-312001-8p7scli8	147	2	intercellular	intercellular	JJ
cord-312001-8p7scli8	147	3	transfer	transfer	NN
cord-312001-8p7scli8	147	4	of	of	IN
cord-312001-8p7scli8	147	5	free	free	JJ
cord-312001-8p7scli8	147	6	or	or	CC
cord-312001-8p7scli8	147	7	packaged	package	VBN
cord-312001-8p7scli8	147	8	cGAMP	cGAMP	NNS
cord-312001-8p7scli8	147	9	permits	permit	VBZ
cord-312001-8p7scli8	147	10	uninfected	uninfected	JJ
cord-312001-8p7scli8	147	11	cells	cell	NNS
cord-312001-8p7scli8	147	12	to	to	TO
cord-312001-8p7scli8	147	13	mount	mount	VB
cord-312001-8p7scli8	147	14	a	a	DT
cord-312001-8p7scli8	147	15	preventive	preventive	JJ
cord-312001-8p7scli8	147	16	IFN	IFN	NNP
cord-312001-8p7scli8	147	17	response	response	NN
cord-312001-8p7scli8	147	18	,	,	,
cord-312001-8p7scli8	147	19	protecting	protect	VBG
cord-312001-8p7scli8	147	20	them	-PRON-	PRP
cord-312001-8p7scli8	147	21	from	from	IN
cord-312001-8p7scli8	147	22	infection	infection	NN
cord-312001-8p7scli8	147	23	or	or	CC
cord-312001-8p7scli8	147	24	providing	provide	VBG
cord-312001-8p7scli8	147	25	a	a	DT
cord-312001-8p7scli8	147	26	faster	fast	JJR
cord-312001-8p7scli8	147	27	response	response	NN
cord-312001-8p7scli8	147	28	to	to	IN
cord-312001-8p7scli8	147	29	DNA	dna	NN
cord-312001-8p7scli8	147	30	viruses	virus	NNS
cord-312001-8p7scli8	147	31	that	that	WDT
cord-312001-8p7scli8	147	32	encode	encode	VBP
cord-312001-8p7scli8	147	33	cGAS	cgas	JJ
cord-312001-8p7scli8	147	34	antagonists	antagonist	NNS
cord-312001-8p7scli8	147	35	.	.	.
cord-312001-8p7scli8	148	1	Upon	upon	IN
cord-312001-8p7scli8	148	2	cGAMP	cGAMP	NNS
cord-312001-8p7scli8	148	3	binding	bind	VBG
cord-312001-8p7scli8	148	4	,	,	,
cord-312001-8p7scli8	148	5	STING	STING	NNP
cord-312001-8p7scli8	148	6	undergoes	undergo	VBZ
cord-312001-8p7scli8	148	7	a	a	DT
cord-312001-8p7scli8	148	8	conformational	conformational	JJ
cord-312001-8p7scli8	148	9	change	change	NN
cord-312001-8p7scli8	148	10	that	that	WDT
cord-312001-8p7scli8	148	11	results	result	VBZ
cord-312001-8p7scli8	148	12	in	in	IN
cord-312001-8p7scli8	148	13	the	the	DT
cord-312001-8p7scli8	148	14	release	release	NN
cord-312001-8p7scli8	148	15	of	of	IN
cord-312001-8p7scli8	148	16	its	-PRON-	PRP$
cord-312001-8p7scli8	148	17	C	c	NN
cord-312001-8p7scli8	148	18	-	-	HYPH
cord-312001-8p7scli8	148	19	terminal	terminal	NN
cord-312001-8p7scli8	148	20	tail	tail	NN
cord-312001-8p7scli8	148	21	(	(	-LRB-
cord-312001-8p7scli8	148	22	CTT	CTT	NNP
cord-312001-8p7scli8	148	23	)	)	-RRB-
cord-312001-8p7scli8	148	24	from	from	IN
cord-312001-8p7scli8	148	25	its	-PRON-	PRP$
cord-312001-8p7scli8	148	26	autoinhibitory	autoinhibitory	JJ
cord-312001-8p7scli8	148	27	state	state	NN
cord-312001-8p7scli8	148	28	and	and	CC
cord-312001-8p7scli8	148	29	in	in	IN
cord-312001-8p7scli8	148	30	the	the	DT
cord-312001-8p7scli8	148	31	formation	formation	NN
cord-312001-8p7scli8	148	32	of	of	IN
cord-312001-8p7scli8	148	33	STING	sting	NN
cord-312001-8p7scli8	148	34	homodimers	homodimer	NNS
cord-312001-8p7scli8	148	35	that	that	WDT
cord-312001-8p7scli8	148	36	translocate	translocate	VBP
cord-312001-8p7scli8	148	37	to	to	IN
cord-312001-8p7scli8	148	38	perinuclear	perinuclear	NN
cord-312001-8p7scli8	148	39	regions	region	NNS
cord-312001-8p7scli8	148	40	to	to	IN
cord-312001-8p7scli8	148	41	colocalize	colocalize	VB
cord-312001-8p7scli8	148	42	with	with	IN
cord-312001-8p7scli8	148	43	TBK1	TBK1	NNP
cord-312001-8p7scli8	148	44	[	[	-LRB-
cord-312001-8p7scli8	148	45	105	105	CD
cord-312001-8p7scli8	148	46	,	,	,
cord-312001-8p7scli8	148	47	118	118	CD
cord-312001-8p7scli8	148	48	,	,	,
cord-312001-8p7scli8	148	49	119	119	CD
cord-312001-8p7scli8	148	50	]	]	-RRB-
cord-312001-8p7scli8	148	51	.	.	.
cord-312001-8p7scli8	149	1	TBK1	TBK1	NNP
cord-312001-8p7scli8	149	2	recruitment	recruitment	NN
cord-312001-8p7scli8	149	3	results	result	NNS
cord-312001-8p7scli8	149	4	in	in	IN
cord-312001-8p7scli8	149	5	the	the	DT
cord-312001-8p7scli8	149	6	phosphorylation	phosphorylation	NN
cord-312001-8p7scli8	149	7	of	of	IN
cord-312001-8p7scli8	149	8	STING	sting	NN
cord-312001-8p7scli8	149	9	and	and	CC
cord-312001-8p7scli8	149	10	the	the	DT
cord-312001-8p7scli8	149	11	phosphorylated	phosphorylated	JJ
cord-312001-8p7scli8	149	12	site	site	NN
cord-312001-8p7scli8	149	13	serves	serve	VBZ
cord-312001-8p7scli8	149	14	as	as	IN
cord-312001-8p7scli8	149	15	a	a	DT
cord-312001-8p7scli8	149	16	platform	platform	NN
cord-312001-8p7scli8	149	17	for	for	IN
cord-312001-8p7scli8	149	18	IRF3	IRF3	NNP
cord-312001-8p7scli8	149	19	dimerization	dimerization	NN
cord-312001-8p7scli8	149	20	and	and	CC
cord-312001-8p7scli8	149	21	activation	activation	NN
cord-312001-8p7scli8	149	22	which	which	WDT
cord-312001-8p7scli8	149	23	ultimately	ultimately	RB
cord-312001-8p7scli8	149	24	results	result	VBZ
cord-312001-8p7scli8	149	25	in	in	IN
cord-312001-8p7scli8	149	26	IFN	IFN	NNP
cord-312001-8p7scli8	149	27	-	-	HYPH
cord-312001-8p7scli8	149	28	β	β	NN
cord-312001-8p7scli8	149	29	induction	induction	NN
cord-312001-8p7scli8	149	30	[	[	-LRB-
cord-312001-8p7scli8	149	31	120	120	CD
cord-312001-8p7scli8	149	32	]	]	-RRB-
cord-312001-8p7scli8	150	1	(	(	-LRB-
cord-312001-8p7scli8	150	2	Figure	figure	NN
cord-312001-8p7scli8	150	3	1	1	CD
cord-312001-8p7scli8	150	4	)	)	-RRB-
cord-312001-8p7scli8	150	5	.	.	.
cord-312001-8p7scli8	151	1	STING	STING	NNP
cord-312001-8p7scli8	151	2	has	have	VBZ
cord-312001-8p7scli8	151	3	also	also	RB
cord-312001-8p7scli8	151	4	been	be	VBN
cord-312001-8p7scli8	151	5	shown	show	VBN
cord-312001-8p7scli8	151	6	to	to	TO
cord-312001-8p7scli8	151	7	induce	induce	VB
cord-312001-8p7scli8	151	8	NF	NF	NNP
cord-312001-8p7scli8	151	9	-	-	HYPH
cord-312001-8p7scli8	151	10	kB	kB	NNP
cord-312001-8p7scli8	151	11	,	,	,
cord-312001-8p7scli8	151	12	MAP	MAP	NNP
cord-312001-8p7scli8	151	13	kinase	kinase	NN
cord-312001-8p7scli8	151	14	and	and	CC
cord-312001-8p7scli8	151	15	STAT6	stat6	NN
cord-312001-8p7scli8	151	16	activation	activation	NN
cord-312001-8p7scli8	151	17	,	,	,
cord-312001-8p7scli8	151	18	as	as	RB
cord-312001-8p7scli8	151	19	well	well	RB
cord-312001-8p7scli8	151	20	as	as	IN
cord-312001-8p7scli8	151	21	the	the	DT
cord-312001-8p7scli8	151	22	stimulation	stimulation	NN
cord-312001-8p7scli8	151	23	of	of	IN
cord-312001-8p7scli8	151	24	LC3	LC3	NNP
cord-312001-8p7scli8	151	25	puncta	puncta	NN
cord-312001-8p7scli8	151	26	formation	formation	NN
cord-312001-8p7scli8	151	27	,	,	,
cord-312001-8p7scli8	151	28	a	a	DT
cord-312001-8p7scli8	151	29	hallmark	hallmark	NN
cord-312001-8p7scli8	151	30	associated	associate	VBN
cord-312001-8p7scli8	151	31	with	with	IN
cord-312001-8p7scli8	151	32	autophagosome	autophagosome	JJ
cord-312001-8p7scli8	151	33	formation	formation	NN
cord-312001-8p7scli8	151	34	[	[	-LRB-
cord-312001-8p7scli8	151	35	119	119	CD
cord-312001-8p7scli8	151	36	,	,	,
cord-312001-8p7scli8	151	37	[	[	-LRB-
cord-312001-8p7scli8	151	38	121	121	CD
cord-312001-8p7scli8	151	39	]	]	-RRB-
cord-312001-8p7scli8	151	40	[	[	-LRB-
cord-312001-8p7scli8	151	41	122	122	CD
cord-312001-8p7scli8	151	42	]	]	-RRB-
cord-312001-8p7scli8	151	43	[	[	-LRB-
cord-312001-8p7scli8	151	44	123	123	CD
cord-312001-8p7scli8	151	45	]	]	-RRB-
cord-312001-8p7scli8	151	46	.	.	.
cord-312001-8p7scli8	152	1	However	however	RB
cord-312001-8p7scli8	152	2	,	,	,
cord-312001-8p7scli8	152	3	the	the	DT
cord-312001-8p7scli8	152	4	molecular	molecular	JJ
cord-312001-8p7scli8	152	5	mechanisms	mechanism	NNS
cord-312001-8p7scli8	152	6	by	by	IN
cord-312001-8p7scli8	152	7	which	which	WDT
cord-312001-8p7scli8	152	8	STING	sting	NN
cord-312001-8p7scli8	152	9	induces	induce	VBZ
cord-312001-8p7scli8	152	10	these	these	DT
cord-312001-8p7scli8	152	11	non	non	AFX
cord-312001-8p7scli8	152	12	-	-	JJ
cord-312001-8p7scli8	152	13	IFN	IFN	NNP
cord-312001-8p7scli8	152	14	responses	response	NNS
cord-312001-8p7scli8	152	15	remain	remain	VBP
cord-312001-8p7scli8	152	16	poorly	poorly	RB
cord-312001-8p7scli8	152	17	understood	understand	VBN
cord-312001-8p7scli8	152	18	.	.	.
cord-312001-8p7scli8	153	1	TLRs	TLRs	NNP
cord-312001-8p7scli8	153	2	comprise	comprise	VBP
cord-312001-8p7scli8	153	3	an	an	DT
cord-312001-8p7scli8	153	4	ancient	ancient	JJ
cord-312001-8p7scli8	153	5	family	family	NN
cord-312001-8p7scli8	153	6	of	of	IN
cord-312001-8p7scli8	153	7	membrane	membrane	NN
cord-312001-8p7scli8	153	8	-	-	HYPH
cord-312001-8p7scli8	153	9	spanning	span	VBG
cord-312001-8p7scli8	153	10	receptors	receptor	NNS
cord-312001-8p7scli8	153	11	that	that	WDT
cord-312001-8p7scli8	153	12	recognize	recognize	VBP
cord-312001-8p7scli8	153	13	ligands	ligand	NNS
cord-312001-8p7scli8	153	14	through	through	IN
cord-312001-8p7scli8	153	15	their	-PRON-	PRP$
cord-312001-8p7scli8	153	16	extracellular	extracellular	JJ
cord-312001-8p7scli8	153	17	domains	domain	NNS
cord-312001-8p7scli8	153	18	and	and	CC
cord-312001-8p7scli8	153	19	initiate	initiate	VB
cord-312001-8p7scli8	153	20	an	an	DT
cord-312001-8p7scli8	153	21	intracellular	intracellular	JJ
cord-312001-8p7scli8	153	22	response	response	NN
cord-312001-8p7scli8	153	23	upon	upon	IN
cord-312001-8p7scli8	153	24	stimulation	stimulation	NN
cord-312001-8p7scli8	153	25	(	(	-LRB-
cord-312001-8p7scli8	153	26	see	see	VB
cord-312001-8p7scli8	153	27	above	above	RB
cord-312001-8p7scli8	153	28	)	)	-RRB-
cord-312001-8p7scli8	153	29	.	.	.
cord-312001-8p7scli8	154	1	The	the	DT
cord-312001-8p7scli8	154	2	Toll	Toll	NNP
cord-312001-8p7scli8	154	3	gene	gene	NN
cord-312001-8p7scli8	154	4	was	be	VBD
cord-312001-8p7scli8	154	5	first	first	RB
cord-312001-8p7scli8	154	6	identified	identify	VBN
cord-312001-8p7scli8	154	7	as	as	IN
cord-312001-8p7scli8	154	8	a	a	DT
cord-312001-8p7scli8	154	9	developmentally	developmentally	RB
cord-312001-8p7scli8	154	10	important	important	JJ
cord-312001-8p7scli8	154	11	gene	gene	NN
cord-312001-8p7scli8	154	12	in	in	IN
cord-312001-8p7scli8	154	13	Drosophila	Drosophila	NNP
cord-312001-8p7scli8	154	14	in	in	IN
cord-312001-8p7scli8	154	15	1985	1985	CD
cord-312001-8p7scli8	154	16	[	[	-LRB-
cord-312001-8p7scli8	154	17	124	124	CD
cord-312001-8p7scli8	154	18	]	]	-RRB-
cord-312001-8p7scli8	154	19	.	.	.
cord-312001-8p7scli8	155	1	In	in	IN
cord-312001-8p7scli8	155	2	the	the	DT
cord-312001-8p7scli8	155	3	mid-1990s	mid-1990	NNS
cord-312001-8p7scli8	155	4	the	the	DT
cord-312001-8p7scli8	155	5	discovery	discovery	NN
cord-312001-8p7scli8	155	6	that	that	IN
cord-312001-8p7scli8	155	7	this	this	DT
cord-312001-8p7scli8	155	8	gene	gene	NN
cord-312001-8p7scli8	155	9	also	also	RB
cord-312001-8p7scli8	155	10	plays	play	VBZ
cord-312001-8p7scli8	155	11	an	an	DT
cord-312001-8p7scli8	155	12	essential	essential	JJ
cord-312001-8p7scli8	155	13	role	role	NN
cord-312001-8p7scli8	155	14	in	in	IN
cord-312001-8p7scli8	155	15	the	the	DT
cord-312001-8p7scli8	155	16	ability	ability	NN
cord-312001-8p7scli8	155	17	of	of	IN
cord-312001-8p7scli8	155	18	Drosophila	Drosophila	NNP
cord-312001-8p7scli8	155	19	to	to	TO
cord-312001-8p7scli8	155	20	resist	resist	VB
cord-312001-8p7scli8	155	21	fungal	fungal	JJ
cord-312001-8p7scli8	155	22	infections	infection	NNS
cord-312001-8p7scli8	155	23	connected	connect	VBN
cord-312001-8p7scli8	155	24	for	for	IN
cord-312001-8p7scli8	155	25	the	the	DT
cord-312001-8p7scli8	155	26	first	first	JJ
cord-312001-8p7scli8	155	27	time	time	NN
cord-312001-8p7scli8	155	28	Toll	toll	NN
cord-312001-8p7scli8	155	29	receptors	receptor	NNS
cord-312001-8p7scli8	155	30	to	to	TO
cord-312001-8p7scli8	155	31	innate	innate	VB
cord-312001-8p7scli8	155	32	immunity	immunity	NN
cord-312001-8p7scli8	155	33	[	[	-LRB-
cord-312001-8p7scli8	155	34	125	125	CD
cord-312001-8p7scli8	155	35	,	,	,
cord-312001-8p7scli8	155	36	126	126	CD
cord-312001-8p7scli8	155	37	]	]	-RRB-
cord-312001-8p7scli8	155	38	.	.	.
cord-312001-8p7scli8	156	1	Although	although	IN
cord-312001-8p7scli8	156	2	in	in	IN
cord-312001-8p7scli8	156	3	flies	fly	NNS
cord-312001-8p7scli8	156	4	Toll	toll	NN
cord-312001-8p7scli8	156	5	functions	function	NNS
cord-312001-8p7scli8	156	6	as	as	IN
cord-312001-8p7scli8	156	7	a	a	DT
cord-312001-8p7scli8	156	8	cytokine	cytokine	NN
cord-312001-8p7scli8	156	9	receptor	receptor	NN
cord-312001-8p7scli8	156	10	,	,	,
cord-312001-8p7scli8	156	11	a	a	DT
cord-312001-8p7scli8	156	12	human	human	JJ
cord-312001-8p7scli8	156	13	Toll	toll	NN
cord-312001-8p7scli8	156	14	receptor	receptor	NN
cord-312001-8p7scli8	156	15	(	(	-LRB-
cord-312001-8p7scli8	156	16	TLR4	TLR4	NNP
cord-312001-8p7scli8	156	17	)	)	-RRB-
cord-312001-8p7scli8	156	18	was	be	VBD
cord-312001-8p7scli8	156	19	rapidly	rapidly	RB
cord-312001-8p7scli8	156	20	identified	identify	VBN
cord-312001-8p7scli8	156	21	[	[	-LRB-
cord-312001-8p7scli8	156	22	127	127	CD
cord-312001-8p7scli8	156	23	,	,	,
cord-312001-8p7scli8	156	24	128	128	CD
cord-312001-8p7scli8	156	25	]	]	-RRB-
cord-312001-8p7scli8	156	26	and	and	CC
cord-312001-8p7scli8	156	27	shown	show	VBN
cord-312001-8p7scli8	156	28	to	to	TO
cord-312001-8p7scli8	156	29	induce	induce	VB
cord-312001-8p7scli8	156	30	an	an	DT
cord-312001-8p7scli8	156	31	immune	immune	JJ
cord-312001-8p7scli8	156	32	response	response	NN
cord-312001-8p7scli8	156	33	in	in	IN
cord-312001-8p7scli8	156	34	mice	mouse	NNS
cord-312001-8p7scli8	156	35	after	after	IN
cord-312001-8p7scli8	156	36	induction	induction	NN
cord-312001-8p7scli8	156	37	by	by	IN
cord-312001-8p7scli8	156	38	LPS	LPS	NNP
cord-312001-8p7scli8	156	39	[	[	-LRB-
cord-312001-8p7scli8	156	40	129	129	CD
cord-312001-8p7scli8	156	41	]	]	-RRB-
cord-312001-8p7scli8	156	42	.	.	.
cord-312001-8p7scli8	157	1	We	-PRON-	PRP
cord-312001-8p7scli8	157	2	now	now	RB
cord-312001-8p7scli8	157	3	know	know	VBP
cord-312001-8p7scli8	157	4	that	that	IN
cord-312001-8p7scli8	157	5	there	there	EX
cord-312001-8p7scli8	157	6	are	be	VBP
cord-312001-8p7scli8	157	7	ten	ten	CD
cord-312001-8p7scli8	157	8	TLRs	tlr	NNS
cord-312001-8p7scli8	157	9	in	in	IN
cord-312001-8p7scli8	157	10	humans	human	NNS
cord-312001-8p7scli8	157	11	that	that	WDT
cord-312001-8p7scli8	157	12	can	can	MD
cord-312001-8p7scli8	157	13	respond	respond	VB
cord-312001-8p7scli8	157	14	to	to	IN
cord-312001-8p7scli8	157	15	many	many	JJ
cord-312001-8p7scli8	157	16	bacterial	bacterial	JJ
cord-312001-8p7scli8	157	17	and	and	CC
cord-312001-8p7scli8	157	18	viral	viral	JJ
cord-312001-8p7scli8	157	19	PAMPs	pamp	NNS
cord-312001-8p7scli8	157	20	[	[	-LRB-
cord-312001-8p7scli8	157	21	130	130	CD
cord-312001-8p7scli8	157	22	]	]	-RRB-
cord-312001-8p7scli8	157	23	.	.	.
cord-312001-8p7scli8	158	1	Prototypical	Prototypical	NNP
cord-312001-8p7scli8	158	2	TLRs	tlr	NNS
cord-312001-8p7scli8	158	3	contain	contain	VBP
cord-312001-8p7scli8	158	4	three	three	CD
cord-312001-8p7scli8	158	5	structural	structural	JJ
cord-312001-8p7scli8	158	6	elements	element	NNS
cord-312001-8p7scli8	158	7	,	,	,
cord-312001-8p7scli8	158	8	a	a	DT
cord-312001-8p7scli8	158	9	hydrophobic	hydrophobic	JJ
cord-312001-8p7scli8	158	10	ectodomain	ectodomain	NN
cord-312001-8p7scli8	158	11	containing	contain	VBG
cord-312001-8p7scli8	158	12	a	a	DT
cord-312001-8p7scli8	158	13	variable	variable	JJ
cord-312001-8p7scli8	158	14	number	number	NN
cord-312001-8p7scli8	158	15	of	of	IN
cord-312001-8p7scli8	158	16	LRRs	lrr	NNS
cord-312001-8p7scli8	158	17	,	,	,
cord-312001-8p7scli8	158	18	a	a	DT
cord-312001-8p7scli8	158	19	transmembrane	transmembrane	NN
cord-312001-8p7scli8	158	20	domain	domain	NN
cord-312001-8p7scli8	158	21	and	and	CC
cord-312001-8p7scli8	158	22	a	a	DT
cord-312001-8p7scli8	158	23	TIR	TIR	NNP
cord-312001-8p7scli8	158	24	domain	domain	NN
cord-312001-8p7scli8	158	25	,	,	,
cord-312001-8p7scli8	158	26	which	which	WDT
cord-312001-8p7scli8	158	27	mediates	mediate	VBZ
cord-312001-8p7scli8	158	28	downstream	downstream	RB
cord-312001-8p7scli8	158	29	signaling	signal	VBG
cord-312001-8p7scli8	158	30	through	through	IN
cord-312001-8p7scli8	158	31	adaptor	adaptor	NN
cord-312001-8p7scli8	158	32	proteins	protein	NNS
cord-312001-8p7scli8	158	33	[	[	-LRB-
cord-312001-8p7scli8	158	34	131	131	CD
cord-312001-8p7scli8	158	35	]	]	-RRB-
cord-312001-8p7scli8	158	36	.	.	.
cord-312001-8p7scli8	159	1	TLRs	tlr	NNS
cord-312001-8p7scli8	159	2	are	be	VBP
cord-312001-8p7scli8	159	3	likely	likely	RB
cord-312001-8p7scli8	159	4	very	very	RB
cord-312001-8p7scli8	159	5	ancient	ancient	JJ
cord-312001-8p7scli8	159	6	immune	immune	JJ
cord-312001-8p7scli8	159	7	sentinels	sentinel	NNS
cord-312001-8p7scli8	159	8	since	since	IN
cord-312001-8p7scli8	159	9	two	two	CD
cord-312001-8p7scli8	159	10	of	of	IN
cord-312001-8p7scli8	159	11	their	-PRON-	PRP$
cord-312001-8p7scli8	159	12	characteristic	characteristic	JJ
cord-312001-8p7scli8	159	13	building	building	NN
cord-312001-8p7scli8	159	14	blocks	block	NNS
cord-312001-8p7scli8	159	15	(	(	-LRB-
cord-312001-8p7scli8	159	16	LRR	LRR	NNP
cord-312001-8p7scli8	159	17	and	and	CC
cord-312001-8p7scli8	159	18	TIR	TIR	NNP
cord-312001-8p7scli8	159	19	domains	domain	NNS
cord-312001-8p7scli8	159	20	)	)	-RRB-
cord-312001-8p7scli8	159	21	are	be	VBP
cord-312001-8p7scli8	159	22	observed	observe	VBN
cord-312001-8p7scli8	159	23	in	in	IN
cord-312001-8p7scli8	159	24	placozoans	placozoans	NNP
cord-312001-8p7scli8	159	25	(	(	-LRB-
cord-312001-8p7scli8	159	26	e.g.	e.g.	RB
cord-312001-8p7scli8	159	27	,	,	,
cord-312001-8p7scli8	159	28	Trichoplax	Trichoplax	NNP
cord-312001-8p7scli8	159	29	animals	animal	NNS
cord-312001-8p7scli8	159	30	)	)	-RRB-
cord-312001-8p7scli8	159	31	[	[	-LRB-
cord-312001-8p7scli8	159	32	132	132	CD
cord-312001-8p7scli8	159	33	]	]	-RRB-
cord-312001-8p7scli8	159	34	and	and	CC
cord-312001-8p7scli8	159	35	Porifera	Porifera	NNP
cord-312001-8p7scli8	159	36	(	(	-LRB-
cord-312001-8p7scli8	159	37	e.g.	e.g.	RB
cord-312001-8p7scli8	159	38	,	,	,
cord-312001-8p7scli8	159	39	Sponges	sponge	NNS
cord-312001-8p7scli8	159	40	)	)	-RRB-
cord-312001-8p7scli8	159	41	[	[	-LRB-
cord-312001-8p7scli8	159	42	131	131	CD
cord-312001-8p7scli8	159	43	]	]	-RRB-
cord-312001-8p7scli8	159	44	.	.	.
cord-312001-8p7scli8	160	1	Full	full	JJ
cord-312001-8p7scli8	160	2	TLRs	tlr	NNS
cord-312001-8p7scli8	160	3	were	be	VBD
cord-312001-8p7scli8	160	4	detected	detect	VBN
cord-312001-8p7scli8	160	5	in	in	IN
cord-312001-8p7scli8	160	6	Cnidarian	cnidarian	JJ
cord-312001-8p7scli8	160	7	species	specie	NNS
cord-312001-8p7scli8	160	8	,	,	,
cord-312001-8p7scli8	160	9	like	like	IN
cord-312001-8p7scli8	160	10	the	the	DT
cord-312001-8p7scli8	160	11	starlet	starlet	NN
cord-312001-8p7scli8	160	12	sea	sea	NN
cord-312001-8p7scli8	160	13	anemone	anemone	NN
cord-312001-8p7scli8	160	14	(	(	-LRB-
cord-312001-8p7scli8	160	15	Nematostella	Nematostella	NNP
cord-312001-8p7scli8	160	16	vectensis	vectensis	NN
cord-312001-8p7scli8	160	17	;	;	:
cord-312001-8p7scli8	160	18	one	one	CD
cord-312001-8p7scli8	160	19	single	single	JJ
cord-312001-8p7scli8	160	20	TLR	TLR	NNP
cord-312001-8p7scli8	160	21	)	)	-RRB-
cord-312001-8p7scli8	160	22	[	[	-LRB-
cord-312001-8p7scli8	160	23	133	133	CD
cord-312001-8p7scli8	160	24	,	,	,
cord-312001-8p7scli8	160	25	134	134	CD
cord-312001-8p7scli8	160	26	]	]	-RRB-
cord-312001-8p7scli8	160	27	and	and	CC
cord-312001-8p7scli8	160	28	the	the	DT
cord-312001-8p7scli8	160	29	acroporid	acroporid	NN
cord-312001-8p7scli8	160	30	corals	coral	NNS
cord-312001-8p7scli8	160	31	(	(	-LRB-
cord-312001-8p7scli8	160	32	Acropora	Acropora	NNP
cord-312001-8p7scli8	160	33	digitifera	digitifera	NN
cord-312001-8p7scli8	160	34	;	;	:
cord-312001-8p7scli8	160	35	four	four	CD
cord-312001-8p7scli8	160	36	TLRs	TLRs	NNPS
cord-312001-8p7scli8	160	37	)	)	-RRB-
cord-312001-8p7scli8	161	1	[	[	-LRB-
cord-312001-8p7scli8	161	2	135	135	CD
cord-312001-8p7scli8	161	3	]	]	-RRB-
cord-312001-8p7scli8	161	4	(	(	-LRB-
cord-312001-8p7scli8	161	5	Figure	figure	NN
cord-312001-8p7scli8	161	6	2	2	CD
cord-312001-8p7scli8	161	7	)	)	-RRB-
cord-312001-8p7scli8	161	8	.	.	.
cord-312001-8p7scli8	162	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	162	2	,	,	,
cord-312001-8p7scli8	162	3	both	both	CC
cord-312001-8p7scli8	162	4	developmental	developmental	JJ
cord-312001-8p7scli8	162	5	and	and	CC
cord-312001-8p7scli8	162	6	immunological	immunological	JJ
cord-312001-8p7scli8	162	7	roles	role	NNS
cord-312001-8p7scli8	162	8	of	of	IN
cord-312001-8p7scli8	162	9	TLRs	tlr	NNS
cord-312001-8p7scli8	162	10	have	have	VBP
cord-312001-8p7scli8	162	11	been	be	VBN
cord-312001-8p7scli8	162	12	described	describe	VBN
cord-312001-8p7scli8	162	13	in	in	IN
cord-312001-8p7scli8	162	14	Cnidarians	Cnidarians	NNPS
cord-312001-8p7scli8	162	15	.	.	.
cord-312001-8p7scli8	163	1	TLRs	tlr	NNS
cord-312001-8p7scli8	163	2	from	from	IN
cord-312001-8p7scli8	163	3	both	both	CC
cord-312001-8p7scli8	163	4	the	the	DT
cord-312001-8p7scli8	163	5	sea	sea	NN
cord-312001-8p7scli8	163	6	anemone	anemone	NN
cord-312001-8p7scli8	163	7	(	(	-LRB-
cord-312001-8p7scli8	163	8	Nematostella	Nematostella	NNP
cord-312001-8p7scli8	163	9	vectensis	vectensis	NN
cord-312001-8p7scli8	163	10	)	)	-RRB-
cord-312001-8p7scli8	163	11	and	and	CC
cord-312001-8p7scli8	163	12	the	the	DT
cord-312001-8p7scli8	163	13	mountainous	mountainous	JJ
cord-312001-8p7scli8	163	14	star	star	NN
cord-312001-8p7scli8	163	15	coral	coral	NN
cord-312001-8p7scli8	163	16	(	(	-LRB-
cord-312001-8p7scli8	163	17	Orbicella	Orbicella	NNP
cord-312001-8p7scli8	163	18	faveolata	faveolata	NN
cord-312001-8p7scli8	163	19	)	)	-RRB-
cord-312001-8p7scli8	163	20	have	have	VBP
cord-312001-8p7scli8	163	21	been	be	VBN
cord-312001-8p7scli8	163	22	shown	show	VBN
cord-312001-8p7scli8	163	23	to	to	TO
cord-312001-8p7scli8	163	24	signal	signal	VB
cord-312001-8p7scli8	163	25	via	via	IN
cord-312001-8p7scli8	163	26	MyD88	MyD88	NNS
cord-312001-8p7scli8	163	27	leading	lead	VBG
cord-312001-8p7scli8	163	28	to	to	IN
cord-312001-8p7scli8	163	29	NF	NF	NNP
cord-312001-8p7scli8	163	30	-	-	HYPH
cord-312001-8p7scli8	163	31	kB	kb	CD
cord-312001-8p7scli8	163	32	activation	activation	NN
cord-312001-8p7scli8	163	33	[	[	-LRB-
cord-312001-8p7scli8	163	34	133	133	CD
cord-312001-8p7scli8	163	35	,	,	,
cord-312001-8p7scli8	163	36	136	136	CD
cord-312001-8p7scli8	163	37	]	]	-RRB-
cord-312001-8p7scli8	163	38	.	.	.
cord-312001-8p7scli8	164	1	In	in	IN
cord-312001-8p7scli8	164	2	the	the	DT
cord-312001-8p7scli8	164	3	Bilateria	Bilateria	NNP
cord-312001-8p7scli8	164	4	phylum	phylum	NN
cord-312001-8p7scli8	164	5	,	,	,
cord-312001-8p7scli8	164	6	TLRs	TLRs	NNP
cord-312001-8p7scli8	164	7	can	can	MD
cord-312001-8p7scli8	164	8	be	be	VB
cord-312001-8p7scli8	164	9	found	find	VBN
cord-312001-8p7scli8	164	10	in	in	IN
cord-312001-8p7scli8	164	11	most	most	RBS
cord-312001-8p7scli8	164	12	studied	study	VBN
cord-312001-8p7scli8	164	13	species	specie	NNS
cord-312001-8p7scli8	164	14	,	,	,
cord-312001-8p7scli8	164	15	however	however	RB
cord-312001-8p7scli8	164	16	,	,	,
cord-312001-8p7scli8	164	17	their	-PRON-	PRP$
cord-312001-8p7scli8	164	18	numbers	number	NNS
cord-312001-8p7scli8	164	19	vary	vary	VBP
cord-312001-8p7scli8	164	20	greatly	greatly	RB
cord-312001-8p7scli8	164	21	among	among	IN
cord-312001-8p7scli8	164	22	species	specie	NNS
cord-312001-8p7scli8	164	23	,	,	,
cord-312001-8p7scli8	164	24	ranging	range	VBG
cord-312001-8p7scli8	164	25	from	from	IN
cord-312001-8p7scli8	164	26	a	a	DT
cord-312001-8p7scli8	164	27	single	single	JJ
cord-312001-8p7scli8	164	28	TLR	tlr	NN
cord-312001-8p7scli8	164	29	in	in	IN
cord-312001-8p7scli8	164	30	Nematodes	nematode	NNS
cord-312001-8p7scli8	164	31	like	like	IN
cord-312001-8p7scli8	164	32	Caenorhabditis	Caenorhabditis	NNP
cord-312001-8p7scli8	164	33	elegans	elegan	NNS
cord-312001-8p7scli8	164	34	,	,	,
cord-312001-8p7scli8	164	35	to	to	IN
cord-312001-8p7scli8	164	36	over	over	IN
cord-312001-8p7scli8	164	37	two	two	CD
cord-312001-8p7scli8	164	38	hundred	hundred	CD
cord-312001-8p7scli8	164	39	in	in	IN
cord-312001-8p7scli8	164	40	echinoderms	echinoderm	NNS
cord-312001-8p7scli8	164	41	like	like	IN
cord-312001-8p7scli8	164	42	the	the	DT
cord-312001-8p7scli8	164	43	pacific	pacific	NNP
cord-312001-8p7scli8	164	44	purple	purple	NNP
cord-312001-8p7scli8	164	45	sea	sea	NNP
cord-312001-8p7scli8	164	46	urchin	urchin	NN
cord-312001-8p7scli8	164	47	Strongylocentrotus	Strongylocentrotus	NNP
cord-312001-8p7scli8	164	48	purpuratus	purpuratus	NN
cord-312001-8p7scli8	164	49	(	(	-LRB-
cord-312001-8p7scli8	164	50	Figure	figure	NN
cord-312001-8p7scli8	164	51	2	2	CD
cord-312001-8p7scli8	164	52	)	)	-RRB-
cord-312001-8p7scli8	164	53	.	.	.
cord-312001-8p7scli8	165	1	The	the	DT
cord-312001-8p7scli8	165	2	expansion	expansion	NN
cord-312001-8p7scli8	165	3	of	of	IN
cord-312001-8p7scli8	165	4	the	the	DT
cord-312001-8p7scli8	165	5	TLR	TLR	NNP
cord-312001-8p7scli8	165	6	repertoire	repertoire	NN
cord-312001-8p7scli8	165	7	in	in	IN
cord-312001-8p7scli8	165	8	some	some	DT
cord-312001-8p7scli8	165	9	animals	animal	NNS
cord-312001-8p7scli8	165	10	like	like	IN
cord-312001-8p7scli8	165	11	the	the	DT
cord-312001-8p7scli8	165	12	sea	sea	NN
cord-312001-8p7scli8	165	13	urchin	urchin	NN
cord-312001-8p7scli8	165	14	,	,	,
cord-312001-8p7scli8	165	15	reflects	reflect	VBZ
cord-312001-8p7scli8	165	16	the	the	DT
cord-312001-8p7scli8	165	17	adaptation	adaptation	NN
cord-312001-8p7scli8	165	18	of	of	IN
cord-312001-8p7scli8	165	19	their	-PRON-	PRP$
cord-312001-8p7scli8	165	20	immune	immune	JJ
cord-312001-8p7scli8	165	21	arsenal	arsenal	NN
cord-312001-8p7scli8	165	22	to	to	TO
cord-312001-8p7scli8	165	23	rapidly	rapidly	RB
cord-312001-8p7scli8	165	24	changing	change	VBG
cord-312001-8p7scli8	165	25	environmental	environmental	JJ
cord-312001-8p7scli8	165	26	stressors	stressor	NNS
cord-312001-8p7scli8	165	27	[	[	-LRB-
cord-312001-8p7scli8	165	28	137	137	CD
cord-312001-8p7scli8	165	29	]	]	-RRB-
cord-312001-8p7scli8	165	30	.	.	.
cord-312001-8p7scli8	166	1	Amongst	amongst	IN
cord-312001-8p7scli8	166	2	a	a	DT
cord-312001-8p7scli8	166	3	multitude	multitude	NN
cord-312001-8p7scli8	166	4	of	of	IN
cord-312001-8p7scli8	166	5	other	other	JJ
cord-312001-8p7scli8	166	6	innate	innate	JJ
cord-312001-8p7scli8	166	7	immune	immune	JJ
cord-312001-8p7scli8	166	8	factors	factor	NNS
cord-312001-8p7scli8	166	9	in	in	IN
cord-312001-8p7scli8	166	10	this	this	DT
cord-312001-8p7scli8	166	11	species	species	NN
cord-312001-8p7scli8	166	12	,	,	,
cord-312001-8p7scli8	166	13	such	such	JJ
cord-312001-8p7scli8	166	14	as	as	IN
cord-312001-8p7scli8	166	15	NACHT	NACHT	NNP
cord-312001-8p7scli8	166	16	domain	domain	NN
cord-312001-8p7scli8	166	17	-	-	HYPH
cord-312001-8p7scli8	166	18	LRRs	lrr	NNS
cord-312001-8p7scli8	166	19	and	and	CC
cord-312001-8p7scli8	166	20	Scavenger	Scavenger	NNP
cord-312001-8p7scli8	166	21	receptors	receptor	NNS
cord-312001-8p7scli8	166	22	,	,	,
cord-312001-8p7scli8	166	23	sea	sea	NN
cord-312001-8p7scli8	166	24	urchin	urchin	NN
cord-312001-8p7scli8	166	25	genomes	genome	NNS
cord-312001-8p7scli8	166	26	encode	encode	VBP
cord-312001-8p7scli8	166	27	for	for	IN
cord-312001-8p7scli8	166	28	222	222	CD
cord-312001-8p7scli8	166	29	TLRs	tlr	NNS
cord-312001-8p7scli8	166	30	.	.	.
cord-312001-8p7scli8	167	1	Among	among	IN
cord-312001-8p7scli8	167	2	those	those	DT
cord-312001-8p7scli8	167	3	,	,	,
cord-312001-8p7scli8	167	4	211	211	CD
cord-312001-8p7scli8	167	5	TLRs	tlr	NNS
cord-312001-8p7scli8	167	6	belong	belong	VBP
cord-312001-8p7scli8	167	7	to	to	IN
cord-312001-8p7scli8	167	8	a	a	DT
cord-312001-8p7scli8	167	9	greatly	greatly	RB
cord-312001-8p7scli8	167	10	expanded	expand	VBN
cord-312001-8p7scli8	167	11	set	set	NN
cord-312001-8p7scli8	167	12	of	of	IN
cord-312001-8p7scli8	167	13	genes	gene	NNS
cord-312001-8p7scli8	167	14	with	with	IN
cord-312001-8p7scli8	167	15	vertebrate	vertebrate	NN
cord-312001-8p7scli8	167	16	like	like	IN
cord-312001-8p7scli8	167	17	features	feature	NNS
cord-312001-8p7scli8	167	18	,	,	,
cord-312001-8p7scli8	167	19	many	many	JJ
cord-312001-8p7scli8	167	20	of	of	IN
cord-312001-8p7scli8	167	21	which	which	WDT
cord-312001-8p7scli8	167	22	seem	seem	VBP
cord-312001-8p7scli8	167	23	to	to	TO
cord-312001-8p7scli8	167	24	have	have	VB
cord-312001-8p7scli8	167	25	duplicated	duplicate	VBN
cord-312001-8p7scli8	167	26	recently	recently	RB
cord-312001-8p7scli8	167	27	.	.	.
cord-312001-8p7scli8	168	1	The	the	DT
cord-312001-8p7scli8	168	2	high	high	JJ
cord-312001-8p7scli8	168	3	prevalence	prevalence	NN
cord-312001-8p7scli8	168	4	of	of	IN
cord-312001-8p7scli8	168	5	pseudogenes	pseudogene	NNS
cord-312001-8p7scli8	168	6	(	(	-LRB-
cord-312001-8p7scli8	168	7	25	25	CD
cord-312001-8p7scli8	168	8	%	%	NN
cord-312001-8p7scli8	168	9	to	to	TO
cord-312001-8p7scli8	168	10	30	30	CD
cord-312001-8p7scli8	168	11	%	%	NN
cord-312001-8p7scli8	168	12	)	)	-RRB-
cord-312001-8p7scli8	168	13	among	among	IN
cord-312001-8p7scli8	168	14	those	those	DT
cord-312001-8p7scli8	168	15	might	may	MD
cord-312001-8p7scli8	168	16	reflect	reflect	VB
cord-312001-8p7scli8	168	17	a	a	DT
cord-312001-8p7scli8	168	18	history	history	NN
cord-312001-8p7scli8	168	19	of	of	IN
cord-312001-8p7scli8	168	20	strong	strong	JJ
cord-312001-8p7scli8	168	21	positive	positive	JJ
cord-312001-8p7scli8	168	22	selective	selective	JJ
cord-312001-8p7scli8	168	23	pressures	pressure	NNS
cord-312001-8p7scli8	168	24	.	.	.
cord-312001-8p7scli8	169	1	Another	another	DT
cord-312001-8p7scli8	169	2	phylum	phylum	NN
cord-312001-8p7scli8	169	3	where	where	WRB
cord-312001-8p7scli8	169	4	TLRs	tlr	NNS
cord-312001-8p7scli8	169	5	have	have	VBP
cord-312001-8p7scli8	169	6	undergone	undergo	VBN
cord-312001-8p7scli8	169	7	a	a	DT
cord-312001-8p7scli8	169	8	significant	significant	JJ
cord-312001-8p7scli8	169	9	expansion	expansion	NN
cord-312001-8p7scli8	169	10	is	be	VBZ
cord-312001-8p7scli8	169	11	in	in	IN
cord-312001-8p7scli8	169	12	Mollusca	Mollusca	NNP
cord-312001-8p7scli8	169	13	[	[	-LRB-
cord-312001-8p7scli8	169	14	138	138	CD
cord-312001-8p7scli8	169	15	]	]	-RRB-
cord-312001-8p7scli8	169	16	,	,	,
cord-312001-8p7scli8	169	17	like	like	IN
cord-312001-8p7scli8	169	18	the	the	DT
cord-312001-8p7scli8	169	19	pacific	pacific	NNP
cord-312001-8p7scli8	169	20	oyster	oyster	NN
cord-312001-8p7scli8	169	21	Crassotrea	Crassotrea	NNP
cord-312001-8p7scli8	169	22	gigas	gigas	NNP
cord-312001-8p7scli8	169	23	[	[	-LRB-
cord-312001-8p7scli8	169	24	139	139	CD
cord-312001-8p7scli8	169	25	]	]	-RRB-
cord-312001-8p7scli8	170	1	(	(	-LRB-
cord-312001-8p7scli8	170	2	Figure	figure	NN
cord-312001-8p7scli8	170	3	2	2	CD
cord-312001-8p7scli8	170	4	)	)	-RRB-
cord-312001-8p7scli8	170	5	.	.	.
cord-312001-8p7scli8	171	1	The	the	DT
cord-312001-8p7scli8	171	2	Pacific	Pacific	NNP
cord-312001-8p7scli8	171	3	Oyster	Oyster	NNP
cord-312001-8p7scli8	171	4	encodes	encode	VBZ
cord-312001-8p7scli8	171	5	for	for	IN
cord-312001-8p7scli8	171	6	83	83	CD
cord-312001-8p7scli8	171	7	TLRs	tlr	NNS
cord-312001-8p7scli8	171	8	in	in	IN
cord-312001-8p7scli8	171	9	total	total	NN
cord-312001-8p7scli8	171	10	,	,	,
cord-312001-8p7scli8	171	11	potentially	potentially	RB
cord-312001-8p7scli8	171	12	reflecting	reflect	VBG
cord-312001-8p7scli8	171	13	a	a	DT
cord-312001-8p7scli8	171	14	highly	highly	RB
cord-312001-8p7scli8	171	15	specialized	specialized	JJ
cord-312001-8p7scli8	171	16	response	response	NN
cord-312001-8p7scli8	171	17	to	to	IN
cord-312001-8p7scli8	171	18	environmental	environmental	JJ
cord-312001-8p7scli8	171	19	challenges	challenge	NNS
cord-312001-8p7scli8	171	20	and	and	CC
cord-312001-8p7scli8	171	21	response	response	NN
cord-312001-8p7scli8	171	22	to	to	IN
cord-312001-8p7scli8	171	23	pathogens	pathogen	NNS
cord-312001-8p7scli8	171	24	.	.	.
cord-312001-8p7scli8	172	1	The	the	DT
cord-312001-8p7scli8	172	2	spread	spread	NN
cord-312001-8p7scli8	172	3	of	of	IN
cord-312001-8p7scli8	172	4	pathogens	pathogen	NNS
cord-312001-8p7scli8	172	5	in	in	IN
cord-312001-8p7scli8	172	6	C.	C.	NNP
cord-312001-8p7scli8	172	7	gigas	gigas	NN
cord-312001-8p7scli8	172	8	natural	natural	JJ
cord-312001-8p7scli8	172	9	habitats	habitat	NNS
cord-312001-8p7scli8	172	10	occurs	occur	VBZ
cord-312001-8p7scli8	172	11	very	very	RB
cord-312001-8p7scli8	172	12	quickly	quickly	RB
cord-312001-8p7scli8	172	13	,	,	,
cord-312001-8p7scli8	172	14	which	which	WDT
cord-312001-8p7scli8	172	15	is	be	VBZ
cord-312001-8p7scli8	172	16	highlighted	highlight	VBN
cord-312001-8p7scli8	172	17	by	by	IN
cord-312001-8p7scli8	172	18	the	the	DT
cord-312001-8p7scli8	172	19	mass	mass	NNP
cord-312001-8p7scli8	172	20	mortality	mortality	NN
cord-312001-8p7scli8	172	21	events	event	VBZ
cord-312001-8p7scli8	172	22	the	the	DT
cord-312001-8p7scli8	172	23	Ostreid	Ostreid	NNP
cord-312001-8p7scli8	172	24	Herpesvirus	Herpesvirus	NNP
cord-312001-8p7scli8	172	25	1	1	CD
cord-312001-8p7scli8	172	26	(	(	-LRB-
cord-312001-8p7scli8	172	27	OsHV1	OsHV1	NNP
cord-312001-8p7scli8	172	28	)	)	-RRB-
cord-312001-8p7scli8	172	29	has	have	VBZ
cord-312001-8p7scli8	172	30	caused	cause	VBN
cord-312001-8p7scli8	172	31	in	in	IN
cord-312001-8p7scli8	172	32	many	many	JJ
cord-312001-8p7scli8	172	33	oyster	oyster	NN
cord-312001-8p7scli8	172	34	nurseries	nursery	NNS
cord-312001-8p7scli8	172	35	.	.	.
cord-312001-8p7scli8	173	1	TLR	TLR	NNP
cord-312001-8p7scli8	173	2	sensing	sensing	NN
cord-312001-8p7scli8	173	3	of	of	IN
cord-312001-8p7scli8	173	4	OSHV1	oshv1	NN
cord-312001-8p7scli8	173	5	results	result	NNS
cord-312001-8p7scli8	173	6	in	in	IN
cord-312001-8p7scli8	173	7	the	the	DT
cord-312001-8p7scli8	173	8	differential	differential	JJ
cord-312001-8p7scli8	173	9	regulation	regulation	NN
cord-312001-8p7scli8	173	10	of	of	IN
cord-312001-8p7scli8	173	11	more	more	JJR
cord-312001-8p7scli8	173	12	than	than	IN
cord-312001-8p7scli8	173	13	a	a	DT
cord-312001-8p7scli8	173	14	thousand	thousand	CD
cord-312001-8p7scli8	173	15	genes	gene	NNS
cord-312001-8p7scli8	173	16	,	,	,
cord-312001-8p7scli8	173	17	many	many	JJ
cord-312001-8p7scli8	173	18	of	of	IN
cord-312001-8p7scli8	173	19	which	which	WDT
cord-312001-8p7scli8	173	20	are	be	VBP
cord-312001-8p7scli8	173	21	related	relate	VBN
cord-312001-8p7scli8	173	22	to	to	IN
cord-312001-8p7scli8	173	23	viral	viral	JJ
cord-312001-8p7scli8	173	24	infection	infection	NN
cord-312001-8p7scli8	173	25	(	(	-LRB-
cord-312001-8p7scli8	173	26	e.g.	e.g.	RB
cord-312001-8p7scli8	173	27	,	,	,
cord-312001-8p7scli8	173	28	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	173	29	DNA	dna	NN
cord-312001-8p7scli8	173	30	sensing	sensing	NN
cord-312001-8p7scli8	173	31	and	and	CC
cord-312001-8p7scli8	173	32	DNA	dna	NN
cord-312001-8p7scli8	173	33	replication	replication	NN
cord-312001-8p7scli8	173	34	)	)	-RRB-
cord-312001-8p7scli8	173	35	[	[	-LRB-
cord-312001-8p7scli8	173	36	5	5	CD
cord-312001-8p7scli8	173	37	,	,	,
cord-312001-8p7scli8	173	38	139	139	CD
cord-312001-8p7scli8	173	39	]	]	-RRB-
cord-312001-8p7scli8	173	40	.	.	.
cord-312001-8p7scli8	174	1	In	in	IN
cord-312001-8p7scli8	174	2	contrast	contrast	NN
cord-312001-8p7scli8	174	3	to	to	IN
cord-312001-8p7scli8	174	4	the	the	DT
cord-312001-8p7scli8	174	5	very	very	RB
cord-312001-8p7scli8	174	6	diverse	diverse	JJ
cord-312001-8p7scli8	174	7	set	set	NN
cord-312001-8p7scli8	174	8	of	of	IN
cord-312001-8p7scli8	174	9	TLR	TLR	NNP
cord-312001-8p7scli8	174	10	repertoires	repertoire	NNS
cord-312001-8p7scli8	174	11	found	find	VBN
cord-312001-8p7scli8	174	12	in	in	IN
cord-312001-8p7scli8	174	13	other	other	JJ
cord-312001-8p7scli8	174	14	Bilateria	Bilateria	NNP
cord-312001-8p7scli8	174	15	species	specie	NNS
cord-312001-8p7scli8	174	16	(	(	-LRB-
cord-312001-8p7scli8	174	17	e.g.	e.g.	RB
cord-312001-8p7scli8	174	18	,	,	,
cord-312001-8p7scli8	174	19	Nematodes	nematode	NNS
cord-312001-8p7scli8	174	20	,	,	,
cord-312001-8p7scli8	174	21	sea	sea	NN
cord-312001-8p7scli8	174	22	urchins	urchin	NNS
cord-312001-8p7scli8	174	23	and	and	CC
cord-312001-8p7scli8	174	24	oysters	oyster	NNS
cord-312001-8p7scli8	174	25	)	)	-RRB-
cord-312001-8p7scli8	174	26	,	,	,
cord-312001-8p7scli8	174	27	chordates	chordate	NNS
cord-312001-8p7scli8	174	28	and	and	CC
cord-312001-8p7scli8	174	29	more	more	RBR
cord-312001-8p7scli8	174	30	particularly	particularly	RB
cord-312001-8p7scli8	174	31	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	174	32	contain	contain	VBP
cord-312001-8p7scli8	174	33	roughly	roughly	RB
cord-312001-8p7scli8	174	34	equal	equal	JJ
cord-312001-8p7scli8	174	35	numbers	number	NNS
cord-312001-8p7scli8	174	36	of	of	IN
cord-312001-8p7scli8	174	37	TLRs	tlr	NNS
cord-312001-8p7scli8	174	38	,	,	,
cord-312001-8p7scli8	174	39	reflecting	reflect	VBG
cord-312001-8p7scli8	174	40	the	the	DT
cord-312001-8p7scli8	174	41	reduced	reduce	VBN
cord-312001-8p7scli8	174	42	need	need	NN
cord-312001-8p7scli8	174	43	for	for	IN
cord-312001-8p7scli8	174	44	highly	highly	RB
cord-312001-8p7scli8	174	45	diversified	diversify	VBN
cord-312001-8p7scli8	174	46	pattern	pattern	NN
cord-312001-8p7scli8	174	47	recognition	recognition	NN
cord-312001-8p7scli8	174	48	due	due	IN
cord-312001-8p7scli8	174	49	to	to	IN
cord-312001-8p7scli8	174	50	the	the	DT
cord-312001-8p7scli8	174	51	acquisition	acquisition	NN
cord-312001-8p7scli8	174	52	of	of	IN
cord-312001-8p7scli8	174	53	adaptive	adaptive	JJ
cord-312001-8p7scli8	174	54	immune	immune	JJ
cord-312001-8p7scli8	174	55	components	component	NNS
cord-312001-8p7scli8	174	56	(	(	-LRB-
cord-312001-8p7scli8	174	57	Figure	figure	NN
cord-312001-8p7scli8	174	58	2	2	CD
cord-312001-8p7scli8	174	59	)	)	-RRB-
cord-312001-8p7scli8	174	60	.	.	.
cord-312001-8p7scli8	175	1	In	in	IN
cord-312001-8p7scli8	175	2	general	general	JJ
cord-312001-8p7scli8	175	3	,	,	,
cord-312001-8p7scli8	175	4	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	175	5	TLRs	tlr	NNS
cord-312001-8p7scli8	175	6	can	can	MD
cord-312001-8p7scli8	175	7	be	be	VB
cord-312001-8p7scli8	175	8	grouped	group	VBN
cord-312001-8p7scli8	175	9	into	into	IN
cord-312001-8p7scli8	175	10	six	six	CD
cord-312001-8p7scli8	175	11	major	major	JJ
cord-312001-8p7scli8	175	12	families	family	NNS
cord-312001-8p7scli8	175	13	[	[	-LRB-
cord-312001-8p7scli8	175	14	15	15	CD
cord-312001-8p7scli8	175	15	]	]	-RRB-
cord-312001-8p7scli8	175	16	.	.	.
cord-312001-8p7scli8	176	1	The	the	DT
cord-312001-8p7scli8	176	2	families	family	NNS
cord-312001-8p7scli8	176	3	responsible	responsible	JJ
cord-312001-8p7scli8	176	4	for	for	IN
cord-312001-8p7scli8	176	5	sensing	sensing	NN
cord-312001-8p7scli8	176	6	of	of	IN
cord-312001-8p7scli8	176	7	viral	viral	JJ
cord-312001-8p7scli8	176	8	PAMPs	pamp	NNS
cord-312001-8p7scli8	176	9	are	be	VBP
cord-312001-8p7scli8	176	10	the	the	DT
cord-312001-8p7scli8	176	11	TLR3	TLR3	NNP
cord-312001-8p7scli8	176	12	family	family	NN
cord-312001-8p7scli8	176	13	,	,	,
cord-312001-8p7scli8	176	14	which	which	WDT
cord-312001-8p7scli8	176	15	recognizes	recognize	VBZ
cord-312001-8p7scli8	176	16	dsRNA	dsrna	NN
cord-312001-8p7scli8	176	17	,	,	,
cord-312001-8p7scli8	176	18	the	the	DT
cord-312001-8p7scli8	176	19	TLR7	TLR7	NNP
cord-312001-8p7scli8	176	20	family	family	NN
cord-312001-8p7scli8	176	21	(	(	-LRB-
cord-312001-8p7scli8	176	22	including	include	VBG
cord-312001-8p7scli8	176	23	TLRs	TLRs	NNP
cord-312001-8p7scli8	176	24	7	7	CD
cord-312001-8p7scli8	176	25	,	,	,
cord-312001-8p7scli8	176	26	8	8	CD
cord-312001-8p7scli8	176	27	and	and	CC
cord-312001-8p7scli8	176	28	9	9	CD
cord-312001-8p7scli8	176	29	)	)	-RRB-
cord-312001-8p7scli8	176	30	which	which	WDT
cord-312001-8p7scli8	176	31	recognizes	recognize	VBZ
cord-312001-8p7scli8	176	32	nucleic	nucleic	JJ
cord-312001-8p7scli8	176	33	acid	acid	NN
cord-312001-8p7scli8	176	34	motifs	motif	NNS
cord-312001-8p7scli8	176	35	and	and	CC
cord-312001-8p7scli8	176	36	the	the	DT
cord-312001-8p7scli8	176	37	large	large	JJ
cord-312001-8p7scli8	176	38	TLR11	TLR11	NNP
cord-312001-8p7scli8	176	39	family	family	NN
cord-312001-8p7scli8	176	40	(	(	-LRB-
cord-312001-8p7scli8	176	41	TLR11	TLR11	NNP
cord-312001-8p7scli8	176	42	,	,	,
cord-312001-8p7scli8	176	43	12	12	CD
cord-312001-8p7scli8	176	44	,	,	,
cord-312001-8p7scli8	176	45	13	13	CD
cord-312001-8p7scli8	176	46	,	,	,
cord-312001-8p7scli8	176	47	19	19	CD
cord-312001-8p7scli8	176	48	,	,	,
cord-312001-8p7scli8	176	49	20	20	CD
cord-312001-8p7scli8	176	50	,	,	,
cord-312001-8p7scli8	176	51	21	21	CD
cord-312001-8p7scli8	176	52	,	,	,
cord-312001-8p7scli8	176	53	22	22	CD
cord-312001-8p7scli8	176	54	,	,	,
cord-312001-8p7scli8	176	55	23	23	CD
cord-312001-8p7scli8	176	56	and	and	CC
cord-312001-8p7scli8	176	57	26	26	CD
cord-312001-8p7scli8	176	58	)	)	-RRB-
cord-312001-8p7scli8	176	59	.	.	.
cord-312001-8p7scli8	177	1	The	the	DT
cord-312001-8p7scli8	177	2	reduced	reduced	JJ
cord-312001-8p7scli8	177	3	number	number	NN
cord-312001-8p7scli8	177	4	of	of	IN
cord-312001-8p7scli8	177	5	TLRs	tlr	NNS
cord-312001-8p7scli8	177	6	in	in	IN
cord-312001-8p7scli8	177	7	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	177	8	does	do	VBZ
cord-312001-8p7scli8	177	9	not	not	RB
cord-312001-8p7scli8	177	10	necessarily	necessarily	RB
cord-312001-8p7scli8	177	11	mean	mean	VB
cord-312001-8p7scli8	177	12	that	that	IN
cord-312001-8p7scli8	177	13	the	the	DT
cord-312001-8p7scli8	177	14	TLR	TLR	NNP
cord-312001-8p7scli8	177	15	-	-	HYPH
cord-312001-8p7scli8	177	16	response	response	NN
cord-312001-8p7scli8	177	17	in	in	IN
cord-312001-8p7scli8	177	18	those	those	DT
cord-312001-8p7scli8	177	19	species	specie	NNS
cord-312001-8p7scli8	177	20	can	can	MD
cord-312001-8p7scli8	177	21	not	not	RB
cord-312001-8p7scli8	177	22	be	be	VB
cord-312001-8p7scli8	177	23	tailored	tailor	VBN
cord-312001-8p7scli8	177	24	to	to	IN
cord-312001-8p7scli8	177	25	a	a	DT
cord-312001-8p7scli8	177	26	particular	particular	JJ
cord-312001-8p7scli8	177	27	environment	environment	NN
cord-312001-8p7scli8	177	28	.	.	.
cord-312001-8p7scli8	178	1	A	a	DT
cord-312001-8p7scli8	178	2	peculiar	peculiar	JJ
cord-312001-8p7scli8	178	3	example	example	NN
cord-312001-8p7scli8	178	4	is	be	VBZ
cord-312001-8p7scli8	178	5	TLR22	tlr22	NN
cord-312001-8p7scli8	178	6	,	,	,
cord-312001-8p7scli8	178	7	one	one	CD
cord-312001-8p7scli8	178	8	of	of	IN
cord-312001-8p7scli8	178	9	two	two	CD
cord-312001-8p7scli8	178	10	virus	virus	NN
cord-312001-8p7scli8	178	11	sensing	sensing	NN
cord-312001-8p7scli8	178	12	TLRs	TLRs	NNP
cord-312001-8p7scli8	178	13	present	present	JJ
cord-312001-8p7scli8	178	14	in	in	IN
cord-312001-8p7scli8	178	15	the	the	DT
cord-312001-8p7scli8	178	16	pufferfish	pufferfish	NN
cord-312001-8p7scli8	178	17	Takifugu	Takifugu	NNP
cord-312001-8p7scli8	178	18	rubripes	rubripe	VBZ
cord-312001-8p7scli8	178	19	.	.	.
cord-312001-8p7scli8	179	1	TLR22	tlr22	NN
cord-312001-8p7scli8	179	2	is	be	VBZ
cord-312001-8p7scli8	179	3	widely	widely	RB
cord-312001-8p7scli8	179	4	conserved	conserve	VBN
cord-312001-8p7scli8	179	5	among	among	IN
cord-312001-8p7scli8	179	6	teleosts	teleost	NNS
cord-312001-8p7scli8	179	7	and	and	CC
cord-312001-8p7scli8	179	8	amphibians	amphibian	NNS
cord-312001-8p7scli8	179	9	but	but	CC
cord-312001-8p7scli8	179	10	does	do	VBZ
cord-312001-8p7scli8	179	11	not	not	RB
cord-312001-8p7scli8	179	12	seem	seem	VB
cord-312001-8p7scli8	179	13	to	to	TO
cord-312001-8p7scli8	179	14	be	be	VB
cord-312001-8p7scli8	179	15	present	present	JJ
cord-312001-8p7scli8	179	16	in	in	IN
cord-312001-8p7scli8	179	17	avian	avian	JJ
cord-312001-8p7scli8	179	18	or	or	CC
cord-312001-8p7scli8	179	19	mammalian	mammalian	JJ
cord-312001-8p7scli8	179	20	animals	animal	NNS
cord-312001-8p7scli8	179	21	,	,	,
cord-312001-8p7scli8	179	22	which	which	WDT
cord-312001-8p7scli8	179	23	indicates	indicate	VBZ
cord-312001-8p7scli8	179	24	that	that	IN
cord-312001-8p7scli8	179	25	TLR22	TLR22	NNP
cord-312001-8p7scli8	179	26	might	may	MD
cord-312001-8p7scli8	179	27	be	be	VB
cord-312001-8p7scli8	179	28	required	require	VBN
cord-312001-8p7scli8	179	29	only	only	RB
cord-312001-8p7scli8	179	30	in	in	IN
cord-312001-8p7scli8	179	31	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	179	32	living	live	VBG
cord-312001-8p7scli8	179	33	in	in	IN
cord-312001-8p7scli8	179	34	water	water	NN
cord-312001-8p7scli8	179	35	[	[	-LRB-
cord-312001-8p7scli8	179	36	140	140	CD
cord-312001-8p7scli8	179	37	]	]	-RRB-
cord-312001-8p7scli8	179	38	.	.	.
cord-312001-8p7scli8	180	1	In	in	IN
cord-312001-8p7scli8	180	2	mammals	mammal	NNS
cord-312001-8p7scli8	180	3	,	,	,
cord-312001-8p7scli8	180	4	one	one	CD
cord-312001-8p7scli8	180	5	last	last	JJ
cord-312001-8p7scli8	180	6	case	case	NN
cord-312001-8p7scli8	180	7	of	of	IN
cord-312001-8p7scli8	180	8	TLR	TLR	NNP
cord-312001-8p7scli8	180	9	adaptation	adaptation	NN
cord-312001-8p7scli8	180	10	and	and	CC
cord-312001-8p7scli8	180	11	rapid	rapid	JJ
cord-312001-8p7scli8	180	12	evolution	evolution	NN
cord-312001-8p7scli8	180	13	that	that	WDT
cord-312001-8p7scli8	180	14	is	be	VBZ
cord-312001-8p7scli8	180	15	worth	worth	JJ
cord-312001-8p7scli8	180	16	mentioning	mention	VBG
cord-312001-8p7scli8	180	17	comes	come	VBZ
cord-312001-8p7scli8	180	18	from	from	IN
cord-312001-8p7scli8	180	19	bat	bat	NN
cord-312001-8p7scli8	180	20	species	specie	NNS
cord-312001-8p7scli8	180	21	.	.	.
cord-312001-8p7scli8	181	1	Analyses	analysis	NNS
cord-312001-8p7scli8	181	2	of	of	IN
cord-312001-8p7scli8	181	3	TLR	TLR	NNP
cord-312001-8p7scli8	181	4	evolution	evolution	NN
cord-312001-8p7scli8	181	5	in	in	IN
cord-312001-8p7scli8	181	6	bats	bat	NNS
cord-312001-8p7scli8	181	7	reveal	reveal	VBP
cord-312001-8p7scli8	181	8	adaptations	adaptation	NNS
cord-312001-8p7scli8	181	9	acquired	acquire	VBN
cord-312001-8p7scli8	181	10	by	by	IN
cord-312001-8p7scli8	181	11	TLRs	TLRs	NNP
cord-312001-8p7scli8	181	12	3	3	CD
cord-312001-8p7scli8	181	13	,	,	,
cord-312001-8p7scli8	181	14	7	7	CD
cord-312001-8p7scli8	181	15	,	,	,
cord-312001-8p7scli8	181	16	8	8	CD
cord-312001-8p7scli8	181	17	and	and	CC
cord-312001-8p7scli8	181	18	9	9	CD
cord-312001-8p7scli8	181	19	,	,	,
cord-312001-8p7scli8	181	20	with	with	IN
cord-312001-8p7scli8	181	21	unique	unique	JJ
cord-312001-8p7scli8	181	22	mutations	mutation	NNS
cord-312001-8p7scli8	181	23	fixed	fix	VBN
cord-312001-8p7scli8	181	24	in	in	IN
cord-312001-8p7scli8	181	25	ligand	ligand	NN
cord-312001-8p7scli8	181	26	-	-	HYPH
cord-312001-8p7scli8	181	27	binding	bind	VBG
cord-312001-8p7scli8	181	28	sites	site	NNS
cord-312001-8p7scli8	181	29	[	[	-LRB-
cord-312001-8p7scli8	181	30	141	141	CD
cord-312001-8p7scli8	181	31	,	,	,
cord-312001-8p7scli8	181	32	142	142	CD
cord-312001-8p7scli8	181	33	]	]	-RRB-
cord-312001-8p7scli8	181	34	.	.	.
cord-312001-8p7scli8	182	1	These	these	DT
cord-312001-8p7scli8	182	2	adaptations	adaptation	NNS
cord-312001-8p7scli8	182	3	are	be	VBP
cord-312001-8p7scli8	182	4	thought	think	VBN
cord-312001-8p7scli8	182	5	to	to	TO
cord-312001-8p7scli8	182	6	stem	stem	VB
cord-312001-8p7scli8	182	7	from	from	IN
cord-312001-8p7scli8	182	8	the	the	DT
cord-312001-8p7scli8	182	9	unique	unique	JJ
cord-312001-8p7scli8	182	10	lifestyle	lifestyle	NN
cord-312001-8p7scli8	182	11	of	of	IN
cord-312001-8p7scli8	182	12	bat	bat	NN
cord-312001-8p7scli8	182	13	species	specie	NNS
cord-312001-8p7scli8	182	14	,	,	,
cord-312001-8p7scli8	182	15	that	that	WDT
cord-312001-8p7scli8	182	16	are	be	VBP
cord-312001-8p7scli8	182	17	the	the	DT
cord-312001-8p7scli8	182	18	only	only	RB
cord-312001-8p7scli8	182	19	known	know	VBN
cord-312001-8p7scli8	182	20	flying	flying	NN
cord-312001-8p7scli8	182	21	mammals	mammal	NNS
cord-312001-8p7scli8	182	22	,	,	,
cord-312001-8p7scli8	182	23	and	and	CC
cord-312001-8p7scli8	182	24	that	that	WDT
cord-312001-8p7scli8	182	25	represent	represent	VBP
cord-312001-8p7scli8	182	26	important	important	JJ
cord-312001-8p7scli8	182	27	viral	viral	JJ
cord-312001-8p7scli8	182	28	reservoirs	reservoir	NNS
cord-312001-8p7scli8	182	29	[	[	-LRB-
cord-312001-8p7scli8	182	30	143	143	CD
cord-312001-8p7scli8	182	31	]	]	-RRB-
cord-312001-8p7scli8	182	32	.	.	.
cord-312001-8p7scli8	183	1	Evolutionary	evolutionary	JJ
cord-312001-8p7scli8	183	2	studies	study	NNS
cord-312001-8p7scli8	183	3	paint	paint	VBP
cord-312001-8p7scli8	183	4	a	a	DT
cord-312001-8p7scli8	183	5	complex	complex	JJ
cord-312001-8p7scli8	183	6	and	and	CC
cord-312001-8p7scli8	183	7	dynamic	dynamic	JJ
cord-312001-8p7scli8	183	8	picture	picture	NN
cord-312001-8p7scli8	183	9	of	of	IN
cord-312001-8p7scli8	183	10	the	the	DT
cord-312001-8p7scli8	183	11	emergence	emergence	NN
cord-312001-8p7scli8	183	12	and	and	CC
cord-312001-8p7scli8	183	13	functional	functional	JJ
cord-312001-8p7scli8	183	14	diversification	diversification	NN
cord-312001-8p7scli8	183	15	of	of	IN
cord-312001-8p7scli8	183	16	RLRs	rlr	NNS
cord-312001-8p7scli8	183	17	across	across	IN
cord-312001-8p7scli8	183	18	the	the	DT
cord-312001-8p7scli8	183	19	animal	animal	NN
cord-312001-8p7scli8	183	20	kingdom	kingdom	NN
cord-312001-8p7scli8	183	21	.	.	.
cord-312001-8p7scli8	184	1	Initially	initially	RB
cord-312001-8p7scli8	184	2	,	,	,
cord-312001-8p7scli8	184	3	several	several	JJ
cord-312001-8p7scli8	184	4	studies	study	NNS
cord-312001-8p7scli8	184	5	proposed	propose	VBD
cord-312001-8p7scli8	184	6	that	that	IN
cord-312001-8p7scli8	184	7	RIG	rig	NN
cord-312001-8p7scli8	184	8	-	-	:
cord-312001-8p7scli8	184	9	I	I	NNP
cord-312001-8p7scli8	184	10	and	and	CC
cord-312001-8p7scli8	184	11	MDA5	MDA5	NNP
cord-312001-8p7scli8	184	12	/	/	SYM
cord-312001-8p7scli8	184	13	LGP2	LGP2	NNP
cord-312001-8p7scli8	184	14	evolved	evolve	VBD
cord-312001-8p7scli8	184	15	in	in	IN
cord-312001-8p7scli8	184	16	animals	animal	NNS
cord-312001-8p7scli8	184	17	independently	independently	RB
cord-312001-8p7scli8	184	18	through	through	IN
cord-312001-8p7scli8	184	19	gene	gene	NN
cord-312001-8p7scli8	184	20	fusion	fusion	NN
cord-312001-8p7scli8	184	21	and	and	CC
cord-312001-8p7scli8	184	22	domain	domain	NN
cord-312001-8p7scli8	184	23	grafting	graft	VBG
cord-312001-8p7scli8	184	24	events	event	NNS
cord-312001-8p7scli8	184	25	[	[	-LRB-
cord-312001-8p7scli8	184	26	16	16	CD
cord-312001-8p7scli8	184	27	,	,	,
cord-312001-8p7scli8	184	28	144	144	CD
cord-312001-8p7scli8	184	29	]	]	-RRB-
cord-312001-8p7scli8	184	30	.	.	.
cord-312001-8p7scli8	185	1	For	for	IN
cord-312001-8p7scli8	185	2	instance	instance	NN
cord-312001-8p7scli8	185	3	,	,	,
cord-312001-8p7scli8	185	4	it	-PRON-	PRP
cord-312001-8p7scli8	185	5	has	have	VBZ
cord-312001-8p7scli8	185	6	been	be	VBN
cord-312001-8p7scli8	185	7	proposed	propose	VBN
cord-312001-8p7scli8	185	8	that	that	IN
cord-312001-8p7scli8	185	9	the	the	DT
cord-312001-8p7scli8	185	10	two	two	CD
cord-312001-8p7scli8	185	11	CARD	card	NN
cord-312001-8p7scli8	185	12	domains	domain	NNS
cord-312001-8p7scli8	185	13	have	have	VBP
cord-312001-8p7scli8	185	14	been	be	VBN
cord-312001-8p7scli8	185	15	acquired	acquire	VBN
cord-312001-8p7scli8	185	16	by	by	IN
cord-312001-8p7scli8	185	17	RIG	rig	NN
cord-312001-8p7scli8	185	18	-	-	:
cord-312001-8p7scli8	185	19	I	I	NNP
cord-312001-8p7scli8	185	20	and	and	CC
cord-312001-8p7scli8	185	21	MDA5	MDA5	NNP
cord-312001-8p7scli8	185	22	in	in	IN
cord-312001-8p7scli8	185	23	two	two	CD
cord-312001-8p7scli8	185	24	separate	separate	JJ
cord-312001-8p7scli8	185	25	events	event	NNS
cord-312001-8p7scli8	185	26	:	:	:
cord-312001-8p7scli8	185	27	The	the	DT
cord-312001-8p7scli8	185	28	first	first	JJ
cord-312001-8p7scli8	185	29	domain	domain	NN
cord-312001-8p7scli8	185	30	being	be	VBG
cord-312001-8p7scli8	185	31	gained	gain	VBN
cord-312001-8p7scli8	185	32	by	by	IN
cord-312001-8p7scli8	185	33	the	the	DT
cord-312001-8p7scli8	185	34	ancestor	ancestor	NN
cord-312001-8p7scli8	185	35	of	of	IN
cord-312001-8p7scli8	185	36	RIG	rig	NN
cord-312001-8p7scli8	185	37	-	-	:
cord-312001-8p7scli8	185	38	I	I	NNP
cord-312001-8p7scli8	185	39	and	and	CC
cord-312001-8p7scli8	185	40	MDA5	MDA5	NNP
cord-312001-8p7scli8	185	41	before	before	IN
cord-312001-8p7scli8	185	42	their	-PRON-	PRP$
cord-312001-8p7scli8	185	43	duplication	duplication	NN
cord-312001-8p7scli8	185	44	and	and	CC
cord-312001-8p7scli8	185	45	the	the	DT
cord-312001-8p7scli8	185	46	second	second	JJ
cord-312001-8p7scli8	185	47	acquired	acquire	VBN
cord-312001-8p7scli8	185	48	after	after	IN
cord-312001-8p7scli8	185	49	their	-PRON-	PRP$
cord-312001-8p7scli8	185	50	divergence	divergence	NN
cord-312001-8p7scli8	185	51	[	[	-LRB-
cord-312001-8p7scli8	185	52	16	16	CD
cord-312001-8p7scli8	185	53	]	]	-RRB-
cord-312001-8p7scli8	185	54	.	.	.
cord-312001-8p7scli8	186	1	These	these	DT
cord-312001-8p7scli8	186	2	studies	study	NNS
cord-312001-8p7scli8	186	3	suggested	suggest	VBD
cord-312001-8p7scli8	186	4	that	that	IN
cord-312001-8p7scli8	186	5	full	full	JJ
cord-312001-8p7scli8	186	6	-	-	HYPH
cord-312001-8p7scli8	186	7	length	length	NN
cord-312001-8p7scli8	186	8	RLRs	rlr	NNS
cord-312001-8p7scli8	186	9	are	be	VBP
cord-312001-8p7scli8	186	10	a	a	DT
cord-312001-8p7scli8	186	11	vertebrate	vertebrate	NN
cord-312001-8p7scli8	186	12	-	-	HYPH
cord-312001-8p7scli8	186	13	specific	specific	JJ
cord-312001-8p7scli8	186	14	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	186	15	novelty	novelty	NN
cord-312001-8p7scli8	186	16	,	,	,
cord-312001-8p7scli8	186	17	although	although	IN
cord-312001-8p7scli8	186	18	their	-PRON-	PRP$
cord-312001-8p7scli8	186	19	building	building	NN
cord-312001-8p7scli8	186	20	blocks	block	NNS
cord-312001-8p7scli8	186	21	may	may	MD
cord-312001-8p7scli8	186	22	have	have	VB
cord-312001-8p7scli8	186	23	been	be	VBN
cord-312001-8p7scli8	186	24	present	present	JJ
cord-312001-8p7scli8	186	25	in	in	IN
cord-312001-8p7scli8	186	26	closely	closely	RB
cord-312001-8p7scli8	186	27	related	relate	VBN
cord-312001-8p7scli8	186	28	invertebrate	invertebrate	JJ
cord-312001-8p7scli8	186	29	animals	animal	NNS
cord-312001-8p7scli8	186	30	[	[	-LRB-
cord-312001-8p7scli8	186	31	16	16	CD
cord-312001-8p7scli8	186	32	,	,	,
cord-312001-8p7scli8	186	33	144	144	CD
cord-312001-8p7scli8	186	34	]	]	-RRB-
cord-312001-8p7scli8	186	35	.	.	.
cord-312001-8p7scli8	187	1	A	a	DT
cord-312001-8p7scli8	187	2	more	more	RBR
cord-312001-8p7scli8	187	3	recent	recent	JJ
cord-312001-8p7scli8	187	4	study	study	NN
cord-312001-8p7scli8	187	5	challenges	challenge	VBZ
cord-312001-8p7scli8	187	6	this	this	DT
cord-312001-8p7scli8	187	7	view	view	NN
cord-312001-8p7scli8	187	8	and	and	CC
cord-312001-8p7scli8	187	9	finds	find	VBZ
cord-312001-8p7scli8	187	10	that	that	IN
cord-312001-8p7scli8	187	11	the	the	DT
cord-312001-8p7scli8	187	12	RLR	RLR	NNP
cord-312001-8p7scli8	187	13	-	-	HYPH
cord-312001-8p7scli8	187	14	based	base	VBN
cord-312001-8p7scli8	187	15	immunity	immunity	NN
cord-312001-8p7scli8	187	16	is	be	VBZ
cord-312001-8p7scli8	187	17	not	not	RB
cord-312001-8p7scli8	187	18	vertebrate	vertebrate	NN
cord-312001-8p7scli8	187	19	-	-	HYPH
cord-312001-8p7scli8	187	20	specific	specific	JJ
cord-312001-8p7scli8	187	21	but	but	CC
cord-312001-8p7scli8	187	22	originated	originate	VBD
cord-312001-8p7scli8	187	23	in	in	IN
cord-312001-8p7scli8	187	24	the	the	DT
cord-312001-8p7scli8	187	25	earliest	early	JJS
cord-312001-8p7scli8	187	26	multicellular	multicellular	JJ
cord-312001-8p7scli8	187	27	animals	animal	NNS
cord-312001-8p7scli8	187	28	[	[	-LRB-
cord-312001-8p7scli8	187	29	14	14	CD
cord-312001-8p7scli8	187	30	]	]	-RRB-
cord-312001-8p7scli8	188	1	(	(	-LRB-
cord-312001-8p7scli8	188	2	Figure	figure	NN
cord-312001-8p7scli8	188	3	2	2	CD
cord-312001-8p7scli8	188	4	)	)	-RRB-
cord-312001-8p7scli8	188	5	.	.	.
cord-312001-8p7scli8	189	1	In	in	IN
cord-312001-8p7scli8	189	2	this	this	DT
cord-312001-8p7scli8	189	3	study	study	NN
cord-312001-8p7scli8	189	4	,	,	,
cord-312001-8p7scli8	189	5	the	the	DT
cord-312001-8p7scli8	189	6	authors	author	NNS
cord-312001-8p7scli8	189	7	show	show	VBP
cord-312001-8p7scli8	189	8	that	that	IN
cord-312001-8p7scli8	189	9	RLRs	rlr	NNS
cord-312001-8p7scli8	189	10	functionally	functionally	RB
cord-312001-8p7scli8	189	11	diversified	diversify	VBN
cord-312001-8p7scli8	189	12	through	through	IN
cord-312001-8p7scli8	189	13	a	a	DT
cord-312001-8p7scli8	189	14	series	series	NN
cord-312001-8p7scli8	189	15	of	of	IN
cord-312001-8p7scli8	189	16	gene	gene	NN
cord-312001-8p7scli8	189	17	duplication	duplication	NN
cord-312001-8p7scli8	189	18	events	event	NNS
cord-312001-8p7scli8	189	19	,	,	,
cord-312001-8p7scli8	189	20	followed	follow	VBN
cord-312001-8p7scli8	189	21	by	by	IN
cord-312001-8p7scli8	189	22	protein	protein	NN
cord-312001-8p7scli8	189	23	-	-	HYPH
cord-312001-8p7scli8	189	24	coding	code	VBG
cord-312001-8p7scli8	189	25	changes	change	NNS
cord-312001-8p7scli8	189	26	that	that	WDT
cord-312001-8p7scli8	189	27	modulated	modulate	VBD
cord-312001-8p7scli8	189	28	their	-PRON-	PRP$
cord-312001-8p7scli8	189	29	RNA	RNA	NNP
cord-312001-8p7scli8	189	30	-	-	HYPH
cord-312001-8p7scli8	189	31	binding	bind	VBG
cord-312001-8p7scli8	189	32	properties	property	NNS
cord-312001-8p7scli8	189	33	.	.	.
cord-312001-8p7scli8	190	1	Using	use	VBG
cord-312001-8p7scli8	190	2	homology	homology	NN
cord-312001-8p7scli8	190	3	-	-	HYPH
cord-312001-8p7scli8	190	4	based	base	VBN
cord-312001-8p7scli8	190	5	gene	gene	NN
cord-312001-8p7scli8	190	6	prediction	prediction	NN
cord-312001-8p7scli8	190	7	based	base	VBN
cord-312001-8p7scli8	190	8	on	on	IN
cord-312001-8p7scli8	190	9	confirmed	confirm	VBN
cord-312001-8p7scli8	190	10	human	human	JJ
cord-312001-8p7scli8	190	11	RLRs	rlr	NNS
cord-312001-8p7scli8	190	12	the	the	DT
cord-312001-8p7scli8	190	13	authors	author	NNS
cord-312001-8p7scli8	190	14	were	be	VBD
cord-312001-8p7scli8	190	15	able	able	JJ
cord-312001-8p7scli8	190	16	to	to	TO
cord-312001-8p7scli8	190	17	identify	identify	VB
cord-312001-8p7scli8	190	18	full	full	JJ
cord-312001-8p7scli8	190	19	-	-	HYPH
cord-312001-8p7scli8	190	20	length	length	NN
cord-312001-8p7scli8	190	21	RLRs	rlr	NNS
cord-312001-8p7scli8	190	22	in	in	IN
cord-312001-8p7scli8	190	23	early	early	RB
cord-312001-8p7scli8	190	24	-	-	HYPH
cord-312001-8p7scli8	190	25	branching	branch	VBG
cord-312001-8p7scli8	190	26	animal	animal	NN
cord-312001-8p7scli8	190	27	genomes	genome	NNS
cord-312001-8p7scli8	190	28	,	,	,
cord-312001-8p7scli8	190	29	including	include	VBG
cord-312001-8p7scli8	190	30	Porifera	Porifera	NNP
cord-312001-8p7scli8	190	31	(	(	-LRB-
cord-312001-8p7scli8	190	32	e.g.	e.g.	RB
cord-312001-8p7scli8	190	33	,	,	,
cord-312001-8p7scli8	190	34	sponges	sponge	NNS
cord-312001-8p7scli8	190	35	)	)	-RRB-
cord-312001-8p7scli8	190	36	and	and	CC
cord-312001-8p7scli8	190	37	Cnidaria	Cnidaria	NNP
cord-312001-8p7scli8	190	38	(	(	-LRB-
cord-312001-8p7scli8	190	39	e.g.	e.g.	RB
cord-312001-8p7scli8	190	40	,	,	,
cord-312001-8p7scli8	190	41	jellyfish	jellyfish	NN
cord-312001-8p7scli8	190	42	)	)	-RRB-
cord-312001-8p7scli8	190	43	.	.	.
cord-312001-8p7scli8	191	1	However	however	RB
cord-312001-8p7scli8	191	2	,	,	,
cord-312001-8p7scli8	191	3	they	-PRON-	PRP
cord-312001-8p7scli8	191	4	were	be	VBD
cord-312001-8p7scli8	191	5	unable	unable	JJ
cord-312001-8p7scli8	191	6	to	to	TO
cord-312001-8p7scli8	191	7	identify	identify	VB
cord-312001-8p7scli8	191	8	RLRs	rlr	NNS
cord-312001-8p7scli8	191	9	in	in	IN
cord-312001-8p7scli8	191	10	non	non	JJ
cord-312001-8p7scli8	191	11	-	-	JJ
cord-312001-8p7scli8	191	12	metazoan	metazoan	JJ
cord-312001-8p7scli8	191	13	eukaryotes	eukaryote	NNS
cord-312001-8p7scli8	191	14	,	,	,
cord-312001-8p7scli8	191	15	including	include	VBG
cord-312001-8p7scli8	191	16	fungi	fungus	NNS
cord-312001-8p7scli8	191	17	and	and	CC
cord-312001-8p7scli8	191	18	choanoflagellates	choanoflagellate	NNS
cord-312001-8p7scli8	191	19	[	[	-LRB-
cord-312001-8p7scli8	191	20	14	14	CD
cord-312001-8p7scli8	191	21	]	]	-RRB-
cord-312001-8p7scli8	192	1	(	(	-LRB-
cord-312001-8p7scli8	192	2	Figure	figure	NN
cord-312001-8p7scli8	192	3	2	2	CD
cord-312001-8p7scli8	192	4	)	)	-RRB-
cord-312001-8p7scli8	192	5	.	.	.
cord-312001-8p7scli8	193	1	It	-PRON-	PRP
cord-312001-8p7scli8	193	2	is	be	VBZ
cord-312001-8p7scli8	193	3	therefore	therefore	RB
cord-312001-8p7scli8	193	4	proposed	propose	VBN
cord-312001-8p7scli8	193	5	that	that	IN
cord-312001-8p7scli8	193	6	the	the	DT
cord-312001-8p7scli8	193	7	ancestral	ancestral	JJ
cord-312001-8p7scli8	193	8	RLR	RLR	NNP
cord-312001-8p7scli8	193	9	(	(	-LRB-
cord-312001-8p7scli8	193	10	RIG	RIG	NNP
cord-312001-8p7scli8	193	11	-	-	HYPH
cord-312001-8p7scli8	193	12	I/	I/	NNP
cord-312001-8p7scli8	194	1	MDA5	MDA5	NNP
cord-312001-8p7scli8	195	1	/LGP2anc	/LGP2anc	NNP
cord-312001-8p7scli8	195	2	)	)	-RRB-
cord-312001-8p7scli8	195	3	duplicated	duplicate	VBN
cord-312001-8p7scli8	195	4	in	in	IN
cord-312001-8p7scli8	195	5	Bilateria	Bilateria	NNP
cord-312001-8p7scli8	195	6	to	to	TO
cord-312001-8p7scli8	195	7	give	give	VB
cord-312001-8p7scli8	195	8	rise	rise	NN
cord-312001-8p7scli8	195	9	to	to	IN
cord-312001-8p7scli8	195	10	RIG	rig	NN
cord-312001-8p7scli8	195	11	-	-	:
cord-312001-8p7scli8	195	12	I	I	NNP
cord-312001-8p7scli8	195	13	and	and	CC
cord-312001-8p7scli8	195	14	MDA5	MDA5	NNP
cord-312001-8p7scli8	195	15	/	/	SYM
cord-312001-8p7scli8	195	16	LGP2	LGP2	NNP
cord-312001-8p7scli8	195	17	lineages	lineage	NNS
cord-312001-8p7scli8	195	18	,	,	,
cord-312001-8p7scli8	195	19	followed	follow	VBN
cord-312001-8p7scli8	195	20	by	by	IN
cord-312001-8p7scli8	195	21	a	a	DT
cord-312001-8p7scli8	195	22	more	more	RBR
cord-312001-8p7scli8	195	23	recent	recent	JJ
cord-312001-8p7scli8	195	24	duplication	duplication	NN
cord-312001-8p7scli8	195	25	of	of	IN
cord-312001-8p7scli8	195	26	the	the	DT
cord-312001-8p7scli8	195	27	MDA5	MDA5	NNP
cord-312001-8p7scli8	195	28	/	/	SYM
cord-312001-8p7scli8	195	29	LGP2	LGP2	NNP
cord-312001-8p7scli8	195	30	ancestor	ancestor	NN
cord-312001-8p7scli8	195	31	,	,	,
cord-312001-8p7scli8	195	32	giving	give	VBG
cord-312001-8p7scli8	195	33	rise	rise	NN
cord-312001-8p7scli8	195	34	to	to	IN
cord-312001-8p7scli8	195	35	MDA5	MDA5	NNP
cord-312001-8p7scli8	195	36	and	and	CC
cord-312001-8p7scli8	195	37	LGP2	LGP2	NNP
cord-312001-8p7scli8	195	38	lineages	lineage	NNS
cord-312001-8p7scli8	195	39	in	in	IN
cord-312001-8p7scli8	195	40	jawed	jawed	JJ
cord-312001-8p7scli8	195	41	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	195	42	after	after	IN
cord-312001-8p7scli8	195	43	their	-PRON-	PRP$
cord-312001-8p7scli8	195	44	split	split	NN
cord-312001-8p7scli8	195	45	from	from	IN
cord-312001-8p7scli8	195	46	jawless	jawless	JJ
cord-312001-8p7scli8	195	47	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	195	48	[	[	-LRB-
cord-312001-8p7scli8	195	49	14	14	CD
cord-312001-8p7scli8	195	50	]	]	-RRB-
cord-312001-8p7scli8	195	51	.	.	.
cord-312001-8p7scli8	196	1	The	the	DT
cord-312001-8p7scli8	196	2	emergence	emergence	NN
cord-312001-8p7scli8	196	3	of	of	IN
cord-312001-8p7scli8	196	4	RLRs	rlr	NNS
cord-312001-8p7scli8	196	5	early	early	RB
cord-312001-8p7scli8	196	6	in	in	IN
cord-312001-8p7scli8	196	7	animal	animal	NN
cord-312001-8p7scli8	196	8	evolution	evolution	NN
cord-312001-8p7scli8	196	9	is	be	VBZ
cord-312001-8p7scli8	196	10	a	a	DT
cord-312001-8p7scli8	196	11	very	very	RB
cord-312001-8p7scli8	196	12	plausible	plausible	JJ
cord-312001-8p7scli8	196	13	scenario	scenario	NN
cord-312001-8p7scli8	196	14	,	,	,
cord-312001-8p7scli8	196	15	since	since	IN
cord-312001-8p7scli8	196	16	other	other	JJ
cord-312001-8p7scli8	196	17	components	component	NNS
cord-312001-8p7scli8	196	18	of	of	IN
cord-312001-8p7scli8	196	19	the	the	DT
cord-312001-8p7scli8	196	20	signaling	signal	VBG
cord-312001-8p7scli8	196	21	pathways	pathway	NNS
cord-312001-8p7scli8	196	22	downstream	downstream	RB
cord-312001-8p7scli8	196	23	of	of	IN
cord-312001-8p7scli8	196	24	RLRs	rlr	NNS
cord-312001-8p7scli8	196	25	,	,	,
cord-312001-8p7scli8	196	26	like	like	IN
cord-312001-8p7scli8	196	27	the	the	DT
cord-312001-8p7scli8	196	28	IRF	IRF	NNP
cord-312001-8p7scli8	196	29	genes	gene	NNS
cord-312001-8p7scli8	196	30	,	,	,
cord-312001-8p7scli8	196	31	are	be	VBP
cord-312001-8p7scli8	196	32	also	also	RB
cord-312001-8p7scli8	196	33	found	find	VBN
cord-312001-8p7scli8	196	34	in	in	IN
cord-312001-8p7scli8	196	35	early	early	JJ
cord-312001-8p7scli8	196	36	metazoans	metazoan	NNS
cord-312001-8p7scli8	196	37	[	[	-LRB-
cord-312001-8p7scli8	196	38	6	6	CD
cord-312001-8p7scli8	196	39	]	]	-RRB-
cord-312001-8p7scli8	197	1	(	(	-LRB-
cord-312001-8p7scli8	197	2	Figure	figure	NN
cord-312001-8p7scli8	197	3	2	2	CD
cord-312001-8p7scli8	197	4	)	)	-RRB-
cord-312001-8p7scli8	197	5	.	.	.
cord-312001-8p7scli8	198	1	Another	another	DT
cord-312001-8p7scli8	198	2	recent	recent	JJ
cord-312001-8p7scli8	198	3	evidence	evidence	NN
cord-312001-8p7scli8	198	4	suggesting	suggest	VBG
cord-312001-8p7scli8	198	5	that	that	IN
cord-312001-8p7scli8	198	6	RLRs	rlr	NNS
cord-312001-8p7scli8	198	7	predated	predate	VBD
cord-312001-8p7scli8	198	8	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	198	9	evolution	evolution	NN
cord-312001-8p7scli8	198	10	comes	come	VBZ
cord-312001-8p7scli8	198	11	from	from	IN
cord-312001-8p7scli8	198	12	studies	study	NNS
cord-312001-8p7scli8	198	13	performed	perform	VBN
cord-312001-8p7scli8	198	14	in	in	IN
cord-312001-8p7scli8	198	15	mollusks	mollusk	NNS
cord-312001-8p7scli8	198	16	(	(	-LRB-
cord-312001-8p7scli8	198	17	pacific	pacific	NNP
cord-312001-8p7scli8	198	18	oyster	oyster	NN
cord-312001-8p7scli8	198	19	;	;	:
cord-312001-8p7scli8	198	20	C.	C.	NNP
cord-312001-8p7scli8	198	21	gigas	gigas	NNP
cord-312001-8p7scli8	198	22	)	)	-RRB-
cord-312001-8p7scli8	198	23	.	.	.
cord-312001-8p7scli8	199	1	The	the	DT
cord-312001-8p7scli8	199	2	invertebrate	invertebrate	JJ
cord-312001-8p7scli8	199	3	C.	C.	NNP
cord-312001-8p7scli8	199	4	gigas	gigas	NN
cord-312001-8p7scli8	199	5	not	not	RB
cord-312001-8p7scli8	199	6	only	only	RB
cord-312001-8p7scli8	199	7	encodes	encode	VBZ
cord-312001-8p7scli8	199	8	up	up	IN
cord-312001-8p7scli8	199	9	to	to	TO
cord-312001-8p7scli8	199	10	12	12	CD
cord-312001-8p7scli8	199	11	RLRs	rlr	NNS
cord-312001-8p7scli8	199	12	,	,	,
cord-312001-8p7scli8	199	13	but	but	CC
cord-312001-8p7scli8	199	14	also	also	RB
cord-312001-8p7scli8	199	15	MAVS	MAVS	NNP
cord-312001-8p7scli8	199	16	,	,	,
cord-312001-8p7scli8	199	17	TRAF6	TRAF6	NNP
cord-312001-8p7scli8	199	18	,	,	,
cord-312001-8p7scli8	199	19	TBK1	TBK1	NNP
cord-312001-8p7scli8	199	20	and	and	CC
cord-312001-8p7scli8	199	21	IRF	IRF	NNP
cord-312001-8p7scli8	199	22	family	family	NN
cord-312001-8p7scli8	199	23	proteins	protein	NNS
cord-312001-8p7scli8	199	24	,	,	,
cord-312001-8p7scli8	199	25	which	which	WDT
cord-312001-8p7scli8	199	26	have	have	VBP
cord-312001-8p7scli8	199	27	been	be	VBN
cord-312001-8p7scli8	199	28	shown	show	VBN
cord-312001-8p7scli8	199	29	to	to	TO
cord-312001-8p7scli8	199	30	have	have	VB
cord-312001-8p7scli8	199	31	functional	functional	JJ
cord-312001-8p7scli8	199	32	antiviral	antiviral	JJ
cord-312001-8p7scli8	199	33	roles	role	NNS
cord-312001-8p7scli8	199	34	[	[	-LRB-
cord-312001-8p7scli8	199	35	5	5	CD
cord-312001-8p7scli8	199	36	,	,	,
cord-312001-8p7scli8	199	37	139	139	CD
cord-312001-8p7scli8	199	38	,	,	,
cord-312001-8p7scli8	199	39	145	145	CD
cord-312001-8p7scli8	199	40	]	]	-RRB-
cord-312001-8p7scli8	200	1	(	(	-LRB-
cord-312001-8p7scli8	200	2	Figure	figure	NN
cord-312001-8p7scli8	200	3	2	2	CD
cord-312001-8p7scli8	200	4	)	)	-RRB-
cord-312001-8p7scli8	200	5	.	.	.
cord-312001-8p7scli8	201	1	Even	even	RB
cord-312001-8p7scli8	201	2	though	though	IN
cord-312001-8p7scli8	201	3	there	there	EX
cord-312001-8p7scli8	201	4	is	be	VBZ
cord-312001-8p7scli8	201	5	no	no	DT
cord-312001-8p7scli8	201	6	consensus	consensus	NN
cord-312001-8p7scli8	201	7	on	on	IN
cord-312001-8p7scli8	201	8	the	the	DT
cord-312001-8p7scli8	201	9	exact	exact	JJ
cord-312001-8p7scli8	201	10	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	201	11	history	history	NN
cord-312001-8p7scli8	201	12	of	of	IN
cord-312001-8p7scli8	201	13	RLRs	rlr	NNS
cord-312001-8p7scli8	201	14	,	,	,
cord-312001-8p7scli8	201	15	it	-PRON-	PRP
cord-312001-8p7scli8	201	16	is	be	VBZ
cord-312001-8p7scli8	201	17	clear	clear	JJ
cord-312001-8p7scli8	201	18	that	that	IN
cord-312001-8p7scli8	201	19	these	these	DT
cord-312001-8p7scli8	201	20	receptors	receptor	NNS
cord-312001-8p7scli8	201	21	(	(	-LRB-
cord-312001-8p7scli8	201	22	and/or	and/or	CC
cord-312001-8p7scli8	201	23	their	-PRON-	PRP$
cord-312001-8p7scli8	201	24	building	building	NN
cord-312001-8p7scli8	201	25	blocks	block	NNS
cord-312001-8p7scli8	201	26	)	)	-RRB-
cord-312001-8p7scli8	201	27	existed	exist	VBD
cord-312001-8p7scli8	201	28	very	very	RB
cord-312001-8p7scli8	201	29	early	early	RB
cord-312001-8p7scli8	201	30	in	in	IN
cord-312001-8p7scli8	201	31	metazoan	metazoan	NN
cord-312001-8p7scli8	201	32	evolution	evolution	NN
cord-312001-8p7scli8	201	33	and	and	CC
cord-312001-8p7scli8	202	1	most	most	RBS
cord-312001-8p7scli8	202	2	importantly	importantly	RB
cord-312001-8p7scli8	202	3	,	,	,
cord-312001-8p7scli8	202	4	they	-PRON-	PRP
cord-312001-8p7scli8	202	5	are	be	VBP
cord-312001-8p7scli8	202	6	subject	subject	JJ
cord-312001-8p7scli8	202	7	to	to	IN
cord-312001-8p7scli8	202	8	a	a	DT
cord-312001-8p7scli8	202	9	very	very	RB
cord-312001-8p7scli8	202	10	dynamic	dynamic	JJ
cord-312001-8p7scli8	202	11	evolution	evolution	NN
cord-312001-8p7scli8	202	12	.	.	.
cord-312001-8p7scli8	203	1	This	this	DT
cord-312001-8p7scli8	203	2	is	be	VBZ
cord-312001-8p7scli8	203	3	illustrated	illustrate	VBN
cord-312001-8p7scli8	203	4	by	by	IN
cord-312001-8p7scli8	203	5	the	the	DT
cord-312001-8p7scli8	203	6	lineage	lineage	NN
cord-312001-8p7scli8	203	7	-	-	HYPH
cord-312001-8p7scli8	203	8	specific	specific	JJ
cord-312001-8p7scli8	203	9	loss	loss	NN
cord-312001-8p7scli8	203	10	of	of	IN
cord-312001-8p7scli8	203	11	RLR	RLR	NNP
cord-312001-8p7scli8	203	12	genes	gene	NNS
cord-312001-8p7scli8	203	13	in	in	IN
cord-312001-8p7scli8	203	14	many	many	JJ
cord-312001-8p7scli8	203	15	species	specie	NNS
cord-312001-8p7scli8	203	16	.	.	.
cord-312001-8p7scli8	204	1	For	for	IN
cord-312001-8p7scli8	204	2	example	example	NN
cord-312001-8p7scli8	204	3	,	,	,
cord-312001-8p7scli8	204	4	although	although	IN
cord-312001-8p7scli8	204	5	MDA5	MDA5	NNP
cord-312001-8p7scli8	204	6	and	and	CC
cord-312001-8p7scli8	204	7	LGP2	LGP2	NNP
cord-312001-8p7scli8	204	8	homologs	homolog	NNS
cord-312001-8p7scli8	204	9	were	be	VBD
cord-312001-8p7scli8	204	10	found	find	VBN
cord-312001-8p7scli8	204	11	in	in	IN
cord-312001-8p7scli8	204	12	many	many	JJ
cord-312001-8p7scli8	204	13	teleost	teleost	NN
cord-312001-8p7scli8	204	14	fish	fish	NN
cord-312001-8p7scli8	204	15	,	,	,
cord-312001-8p7scli8	204	16	RIG-	RIG-	NNP
cord-312001-8p7scli8	205	1	I	-PRON-	PRP
cord-312001-8p7scli8	205	2	homologs	homolog	NNS
cord-312001-8p7scli8	205	3	have	have	VBP
cord-312001-8p7scli8	205	4	only	only	RB
cord-312001-8p7scli8	205	5	been	be	VBN
cord-312001-8p7scli8	205	6	identified	identify	VBN
cord-312001-8p7scli8	205	7	in	in	IN
cord-312001-8p7scli8	205	8	some	some	DT
cord-312001-8p7scli8	205	9	fish	fish	NN
cord-312001-8p7scli8	205	10	species	specie	NNS
cord-312001-8p7scli8	205	11	like	like	IN
cord-312001-8p7scli8	205	12	salmon	salmon	NN
cord-312001-8p7scli8	205	13	and	and	CC
cord-312001-8p7scli8	205	14	carp	carp	VB
cord-312001-8p7scli8	205	15	[	[	-LRB-
cord-312001-8p7scli8	205	16	146	146	CD
cord-312001-8p7scli8	205	17	]	]	-RRB-
cord-312001-8p7scli8	205	18	.	.	.
cord-312001-8p7scli8	206	1	RIG	rig	NN
cord-312001-8p7scli8	206	2	-	-	:
cord-312001-8p7scli8	206	3	I	-PRON-	PRP
cord-312001-8p7scli8	206	4	is	be	VBZ
cord-312001-8p7scli8	206	5	absent	absent	JJ
cord-312001-8p7scli8	206	6	in	in	IN
cord-312001-8p7scli8	206	7	the	the	DT
cord-312001-8p7scli8	206	8	chicken	chicken	NN
cord-312001-8p7scli8	206	9	genome	genome	NN
cord-312001-8p7scli8	206	10	although	although	IN
cord-312001-8p7scli8	206	11	MDA5	MDA5	NNP
cord-312001-8p7scli8	206	12	and	and	CC
cord-312001-8p7scli8	206	13	LGP2	LGP2	NNP
cord-312001-8p7scli8	206	14	are	be	VBP
cord-312001-8p7scli8	206	15	both	both	DT
cord-312001-8p7scli8	206	16	present	present	JJ
cord-312001-8p7scli8	206	17	[	[	-LRB-
cord-312001-8p7scli8	206	18	147	147	CD
cord-312001-8p7scli8	206	19	,	,	,
cord-312001-8p7scli8	206	20	148	148	CD
cord-312001-8p7scli8	206	21	]	]	-RRB-
cord-312001-8p7scli8	206	22	.	.	.
cord-312001-8p7scli8	207	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	207	2	,	,	,
cord-312001-8p7scli8	207	3	chickens	chicken	NNS
cord-312001-8p7scli8	207	4	suffer	suffer	VBP
cord-312001-8p7scli8	207	5	severely	severely	RB
cord-312001-8p7scli8	207	6	from	from	IN
cord-312001-8p7scli8	207	7	avian	avian	JJ
cord-312001-8p7scli8	207	8	influenza	influenza	NN
cord-312001-8p7scli8	207	9	virus	virus	NN
cord-312001-8p7scli8	207	10	(	(	-LRB-
cord-312001-8p7scli8	207	11	AIV	AIV	NNP
cord-312001-8p7scli8	207	12	)	)	-RRB-
cord-312001-8p7scli8	207	13	infection	infection	NN
cord-312001-8p7scli8	207	14	compared	compare	VBN
cord-312001-8p7scli8	207	15	to	to	IN
cord-312001-8p7scli8	207	16	ducks	duck	NNS
cord-312001-8p7scli8	207	17	(	(	-LRB-
cord-312001-8p7scli8	207	18	that	that	WDT
cord-312001-8p7scli8	207	19	do	do	VBP
cord-312001-8p7scli8	207	20	possess	possess	VB
cord-312001-8p7scli8	207	21	the	the	DT
cord-312001-8p7scli8	207	22	RIG	rig	NN
cord-312001-8p7scli8	207	23	-	-	HYPH
cord-312001-8p7scli8	207	24	I	i	NN
cord-312001-8p7scli8	207	25	gene	gene	NN
cord-312001-8p7scli8	207	26	)	)	-RRB-
cord-312001-8p7scli8	207	27	which	which	WDT
cord-312001-8p7scli8	207	28	could	could	MD
cord-312001-8p7scli8	207	29	be	be	VB
cord-312001-8p7scli8	207	30	due	due	JJ
cord-312001-8p7scli8	207	31	to	to	IN
cord-312001-8p7scli8	207	32	the	the	DT
cord-312001-8p7scli8	207	33	loss	loss	NN
cord-312001-8p7scli8	207	34	of	of	IN
cord-312001-8p7scli8	207	35	RIG	rig	NN
cord-312001-8p7scli8	208	1	-I	-I	:
cord-312001-8p7scli8	208	2	affecting	affect	VBG
cord-312001-8p7scli8	208	3	their	-PRON-	PRP$
cord-312001-8p7scli8	208	4	first	first	JJ
cord-312001-8p7scli8	208	5	line	line	NN
cord-312001-8p7scli8	208	6	of	of	IN
cord-312001-8p7scli8	208	7	defense	defense	NN
cord-312001-8p7scli8	208	8	in	in	IN
cord-312001-8p7scli8	208	9	epithelial	epithelial	JJ
cord-312001-8p7scli8	208	10	cells	cell	NNS
cord-312001-8p7scli8	208	11	[	[	-LRB-
cord-312001-8p7scli8	208	12	148	148	CD
cord-312001-8p7scli8	208	13	]	]	-RRB-
cord-312001-8p7scli8	208	14	.	.	.
cord-312001-8p7scli8	209	1	Most	most	RBS
cord-312001-8p7scli8	209	2	studied	study	VBN
cord-312001-8p7scli8	209	3	mammals	mammal	NNS
cord-312001-8p7scli8	209	4	possess	possess	VBP
cord-312001-8p7scli8	209	5	RIG	rig	NN
cord-312001-8p7scli8	210	1	-I	-I	NNP
cord-312001-8p7scli8	210	2	,	,	,
cord-312001-8p7scli8	210	3	however	however	RB
cord-312001-8p7scli8	210	4	,	,	,
cord-312001-8p7scli8	210	5	it	-PRON-	PRP
cord-312001-8p7scli8	210	6	has	have	VBZ
cord-312001-8p7scli8	210	7	been	be	VBN
cord-312001-8p7scli8	210	8	lost	lose	VBN
cord-312001-8p7scli8	210	9	in	in	IN
cord-312001-8p7scli8	210	10	at	at	RB
cord-312001-8p7scli8	210	11	least	least	RBS
cord-312001-8p7scli8	210	12	one	one	CD
cord-312001-8p7scli8	210	13	mammalian	mammalian	JJ
cord-312001-8p7scli8	210	14	species	specie	NNS
cord-312001-8p7scli8	210	15	;	;	:
cord-312001-8p7scli8	210	16	the	the	DT
cord-312001-8p7scli8	210	17	Chinese	chinese	JJ
cord-312001-8p7scli8	210	18	tree	tree	NN
cord-312001-8p7scli8	210	19	shrew	shrew	NN
cord-312001-8p7scli8	210	20	[	[	-LRB-
cord-312001-8p7scli8	210	21	149	149	CD
cord-312001-8p7scli8	210	22	]	]	-RRB-
cord-312001-8p7scli8	210	23	.	.	.
cord-312001-8p7scli8	211	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	211	2	,	,	,
cord-312001-8p7scli8	211	3	with	with	IN
cord-312001-8p7scli8	211	4	the	the	DT
cord-312001-8p7scli8	211	5	loss	loss	NN
cord-312001-8p7scli8	211	6	of	of	IN
cord-312001-8p7scli8	211	7	RIG	rig	NN
cord-312001-8p7scli8	211	8	-	-	:
cord-312001-8p7scli8	211	9	I	I	NNP
cord-312001-8p7scli8	211	10	,	,	,
cord-312001-8p7scli8	211	11	both	both	CC
cord-312001-8p7scli8	211	12	MDA5	MDA5	NNP
cord-312001-8p7scli8	211	13	and	and	CC
cord-312001-8p7scli8	211	14	LGP2	LGP2	NNP
cord-312001-8p7scli8	211	15	have	have	VBP
cord-312001-8p7scli8	211	16	undergone	undergo	VBN
cord-312001-8p7scli8	211	17	strong	strong	JJ
cord-312001-8p7scli8	211	18	positive	positive	JJ
cord-312001-8p7scli8	211	19	selection	selection	NN
cord-312001-8p7scli8	211	20	in	in	IN
cord-312001-8p7scli8	211	21	Chinese	chinese	JJ
cord-312001-8p7scli8	211	22	tree	tree	NN
cord-312001-8p7scli8	211	23	shrews	shrew	NNS
cord-312001-8p7scli8	211	24	,	,	,
cord-312001-8p7scli8	211	25	and	and	CC
cord-312001-8p7scli8	211	26	positively	positively	RB
cord-312001-8p7scli8	211	27	selected	select	VBN
cord-312001-8p7scli8	211	28	sites	site	NNS
cord-312001-8p7scli8	211	29	in	in	IN
cord-312001-8p7scli8	211	30	MDA5	MDA5	NNP
cord-312001-8p7scli8	211	31	endowed	endow	VBD
cord-312001-8p7scli8	211	32	the	the	DT
cord-312001-8p7scli8	211	33	substitute	substitute	JJ
cord-312001-8p7scli8	211	34	function	function	NN
cord-312001-8p7scli8	211	35	for	for	IN
cord-312001-8p7scli8	211	36	the	the	DT
cord-312001-8p7scli8	211	37	lost	lose	VBN
cord-312001-8p7scli8	211	38	RIG	rig	NN
cord-312001-8p7scli8	211	39	-	-	:
cord-312001-8p7scli8	211	40	I	-PRON-	PRP
cord-312001-8p7scli8	211	41	[	[	-LRB-
cord-312001-8p7scli8	211	42	150	150	CD
cord-312001-8p7scli8	211	43	]	]	-RRB-
cord-312001-8p7scli8	211	44	.	.	.
cord-312001-8p7scli8	212	1	Another	another	DT
cord-312001-8p7scli8	212	2	eloquent	eloquent	JJ
cord-312001-8p7scli8	212	3	example	example	NN
cord-312001-8p7scli8	212	4	illustrating	illustrate	VBG
cord-312001-8p7scli8	212	5	the	the	DT
cord-312001-8p7scli8	212	6	dynamic	dynamic	JJ
cord-312001-8p7scli8	212	7	evolution	evolution	NN
cord-312001-8p7scli8	212	8	of	of	IN
cord-312001-8p7scli8	212	9	these	these	DT
cord-312001-8p7scli8	212	10	receptors	receptor	NNS
cord-312001-8p7scli8	212	11	is	be	VBZ
cord-312001-8p7scli8	212	12	the	the	DT
cord-312001-8p7scli8	212	13	loss	loss	NN
cord-312001-8p7scli8	212	14	of	of	IN
cord-312001-8p7scli8	212	15	all	all	DT
cord-312001-8p7scli8	212	16	RLR	RLR	NNP
cord-312001-8p7scli8	212	17	genes	gene	NNS
cord-312001-8p7scli8	212	18	(	(	-LRB-
cord-312001-8p7scli8	212	19	RIG	rig	NN
cord-312001-8p7scli8	212	20	-	-	HYPH
cord-312001-8p7scli8	212	21	I	I	NNP
cord-312001-8p7scli8	212	22	,	,	,
cord-312001-8p7scli8	212	23	MDA5	MDA5	NNP
cord-312001-8p7scli8	212	24	and	and	CC
cord-312001-8p7scli8	212	25	LGP2	LGP2	NNP
cord-312001-8p7scli8	212	26	)	)	-RRB-
cord-312001-8p7scli8	212	27	in	in	IN
cord-312001-8p7scli8	212	28	insects	insect	NNS
cord-312001-8p7scli8	212	29	(	(	-LRB-
cord-312001-8p7scli8	212	30	Figure	figure	NN
cord-312001-8p7scli8	212	31	2	2	CD
cord-312001-8p7scli8	212	32	)	)	-RRB-
cord-312001-8p7scli8	212	33	.	.	.
cord-312001-8p7scli8	213	1	In	in	IN
cord-312001-8p7scli8	213	2	Drosophila	Drosophila	NNP
cord-312001-8p7scli8	213	3	,	,	,
cord-312001-8p7scli8	213	4	for	for	IN
cord-312001-8p7scli8	213	5	example	example	NN
cord-312001-8p7scli8	213	6	,	,	,
cord-312001-8p7scli8	213	7	although	although	IN
cord-312001-8p7scli8	213	8	the	the	DT
cord-312001-8p7scli8	213	9	NF	NF	NNP
cord-312001-8p7scli8	213	10	-	-	HYPH
cord-312001-8p7scli8	213	11	kb	kb	NNP
cord-312001-8p7scli8	213	12	and	and	CC
cord-312001-8p7scli8	213	13	JAK	JAK	NNP
cord-312001-8p7scli8	213	14	/	/	SYM
cord-312001-8p7scli8	213	15	STAT	stat	NN
cord-312001-8p7scli8	213	16	pathways	pathway	NNS
cord-312001-8p7scli8	213	17	are	be	VBP
cord-312001-8p7scli8	213	18	present	present	JJ
cord-312001-8p7scli8	213	19	and	and	CC
cord-312001-8p7scli8	213	20	contribute	contribute	VB
cord-312001-8p7scli8	213	21	to	to	IN
cord-312001-8p7scli8	213	22	antiviral	antiviral	JJ
cord-312001-8p7scli8	213	23	defenses	defense	NNS
cord-312001-8p7scli8	213	24	[	[	-LRB-
cord-312001-8p7scli8	213	25	151	151	CD
cord-312001-8p7scli8	213	26	,	,	,
cord-312001-8p7scli8	213	27	152	152	CD
cord-312001-8p7scli8	213	28	]	]	-RRB-
cord-312001-8p7scli8	213	29	,	,	,
cord-312001-8p7scli8	213	30	all	all	DT
cord-312001-8p7scli8	213	31	components	component	NNS
cord-312001-8p7scli8	213	32	of	of	IN
cord-312001-8p7scli8	213	33	the	the	DT
cord-312001-8p7scli8	213	34	RLR	RLR	NNP
cord-312001-8p7scli8	213	35	-	-	HYPH
cord-312001-8p7scli8	213	36	MAVS	MAVS	NNP
cord-312001-8p7scli8	213	37	-	-	HYPH
cord-312001-8p7scli8	213	38	IRF	IRF	NNP
cord-312001-8p7scli8	213	39	-	-	HYPH
cord-312001-8p7scli8	213	40	axis	axis	NN
cord-312001-8p7scli8	213	41	have	have	VBP
cord-312001-8p7scli8	213	42	been	be	VBN
cord-312001-8p7scli8	213	43	lost	lose	VBN
cord-312001-8p7scli8	213	44	.	.	.
cord-312001-8p7scli8	214	1	Instead	instead	RB
cord-312001-8p7scli8	214	2	,	,	,
cord-312001-8p7scli8	214	3	Drosophila	Drosophila	NNP
cord-312001-8p7scli8	214	4	like	like	IN
cord-312001-8p7scli8	214	5	other	other	JJ
cord-312001-8p7scli8	214	6	insects	insect	NNS
cord-312001-8p7scli8	214	7	and	and	CC
cord-312001-8p7scli8	214	8	relies	rely	VBZ
cord-312001-8p7scli8	214	9	on	on	IN
cord-312001-8p7scli8	214	10	the	the	DT
cord-312001-8p7scli8	214	11	RNAi	RNAi	NNP
cord-312001-8p7scli8	214	12	mechanism	mechanism	NN
cord-312001-8p7scli8	214	13	as	as	IN
cord-312001-8p7scli8	214	14	the	the	DT
cord-312001-8p7scli8	214	15	major	major	JJ
cord-312001-8p7scli8	214	16	antiviral	antiviral	JJ
cord-312001-8p7scli8	214	17	system	system	NN
cord-312001-8p7scli8	214	18	protecting	protect	VBG
cord-312001-8p7scli8	214	19	it	-PRON-	PRP
cord-312001-8p7scli8	214	20	from	from	IN
cord-312001-8p7scli8	214	21	viral	viral	JJ
cord-312001-8p7scli8	214	22	infections	infection	NNS
cord-312001-8p7scli8	214	23	[	[	-LRB-
cord-312001-8p7scli8	214	24	24	24	CD
cord-312001-8p7scli8	214	25	,	,	,
cord-312001-8p7scli8	214	26	153	153	CD
cord-312001-8p7scli8	214	27	,	,	,
cord-312001-8p7scli8	214	28	154	154	CD
cord-312001-8p7scli8	214	29	]	]	-RRB-
cord-312001-8p7scli8	214	30	.	.	.
cord-312001-8p7scli8	215	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	215	2	the	the	DT
cord-312001-8p7scli8	215	3	RNase	RNase	NNP
cord-312001-8p7scli8	215	4	III	III	NNP
cord-312001-8p7scli8	215	5	Dicer-2	Dicer-2	NNP
cord-312001-8p7scli8	215	6	,	,	,
cord-312001-8p7scli8	215	7	a	a	DT
cord-312001-8p7scli8	215	8	central	central	JJ
cord-312001-8p7scli8	215	9	player	player	NN
cord-312001-8p7scli8	215	10	in	in	IN
cord-312001-8p7scli8	215	11	insect	insect	NN
cord-312001-8p7scli8	215	12	antiviral	antiviral	JJ
cord-312001-8p7scli8	215	13	immunity	immunity	NN
cord-312001-8p7scli8	215	14	,	,	,
cord-312001-8p7scli8	215	15	responsible	responsible	JJ
cord-312001-8p7scli8	215	16	for	for	IN
cord-312001-8p7scli8	215	17	generating	generate	VBG
cord-312001-8p7scli8	215	18	small	small	JJ
cord-312001-8p7scli8	215	19	interfering	interfere	VBG
cord-312001-8p7scli8	215	20	RNAs	rna	NNS
cord-312001-8p7scli8	215	21	(	(	-LRB-
cord-312001-8p7scli8	215	22	siRNAs	siRNAs	NNP
cord-312001-8p7scli8	215	23	)	)	-RRB-
cord-312001-8p7scli8	215	24	,	,	,
cord-312001-8p7scli8	215	25	also	also	RB
cord-312001-8p7scli8	215	26	contains	contain	VBZ
cord-312001-8p7scli8	215	27	an	an	DT
cord-312001-8p7scli8	215	28	N	n	CD
cord-312001-8p7scli8	215	29	-	-	HYPH
cord-312001-8p7scli8	215	30	terminal	terminal	NN
cord-312001-8p7scli8	215	31	DExD	DExD	NNS
cord-312001-8p7scli8	215	32	/	/	SYM
cord-312001-8p7scli8	215	33	H	H	NNP
cord-312001-8p7scli8	215	34	-	-	HYPH
cord-312001-8p7scli8	215	35	box	box	NN
cord-312001-8p7scli8	215	36	helicase	helicase	NN
cord-312001-8p7scli8	215	37	domain	domain	NN
cord-312001-8p7scli8	215	38	that	that	WDT
cord-312001-8p7scli8	215	39	is	be	VBZ
cord-312001-8p7scli8	215	40	highly	highly	RB
cord-312001-8p7scli8	215	41	homologous	homologous	JJ
cord-312001-8p7scli8	215	42	to	to	IN
cord-312001-8p7scli8	215	43	the	the	DT
cord-312001-8p7scli8	215	44	helicase	helicase	NN
cord-312001-8p7scli8	215	45	domains	domain	NNS
cord-312001-8p7scli8	215	46	of	of	IN
cord-312001-8p7scli8	215	47	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	215	48	RLRs	rlr	NNS
cord-312001-8p7scli8	215	49	[	[	-LRB-
cord-312001-8p7scli8	215	50	155	155	CD
cord-312001-8p7scli8	215	51	,	,	,
cord-312001-8p7scli8	215	52	156	156	CD
cord-312001-8p7scli8	215	53	]	]	-RRB-
cord-312001-8p7scli8	215	54	.	.	.
cord-312001-8p7scli8	216	1	Moreover	moreover	RB
cord-312001-8p7scli8	216	2	,	,	,
cord-312001-8p7scli8	216	3	Dicer-2	Dicer-2	NNP
cord-312001-8p7scli8	216	4	has	have	VBZ
cord-312001-8p7scli8	216	5	been	be	VBN
cord-312001-8p7scli8	216	6	shown	show	VBN
cord-312001-8p7scli8	216	7	to	to	TO
cord-312001-8p7scli8	216	8	be	be	VB
cord-312001-8p7scli8	216	9	responsible	responsible	JJ
cord-312001-8p7scli8	216	10	for	for	IN
cord-312001-8p7scli8	216	11	the	the	DT
cord-312001-8p7scli8	216	12	transcriptional	transcriptional	JJ
cord-312001-8p7scli8	216	13	upregulation	upregulation	NN
cord-312001-8p7scli8	216	14	of	of	IN
cord-312001-8p7scli8	216	15	an	an	DT
cord-312001-8p7scli8	216	16	antiviral	antiviral	JJ
cord-312001-8p7scli8	216	17	gene	gene	NN
cord-312001-8p7scli8	216	18	(	(	-LRB-
cord-312001-8p7scli8	216	19	Vago	Vago	NNP
cord-312001-8p7scli8	216	20	)	)	-RRB-
cord-312001-8p7scli8	216	21	that	that	WDT
cord-312001-8p7scli8	216	22	could	could	MD
cord-312001-8p7scli8	216	23	function	function	VB
cord-312001-8p7scli8	216	24	as	as	IN
cord-312001-8p7scli8	216	25	a	a	DT
cord-312001-8p7scli8	216	26	cytokine	cytokine	NN
cord-312001-8p7scli8	216	27	by	by	IN
cord-312001-8p7scli8	216	28	activating	activate	VBG
cord-312001-8p7scli8	216	29	the	the	DT
cord-312001-8p7scli8	216	30	JAK	JAK	NNP
cord-312001-8p7scli8	216	31	/	/	SYM
cord-312001-8p7scli8	216	32	STAT	stat	NN
cord-312001-8p7scli8	216	33	pathway	pathway	NN
cord-312001-8p7scli8	216	34	and	and	CC
cord-312001-8p7scli8	216	35	triggering	trigger	VBG
cord-312001-8p7scli8	216	36	systemic	systemic	JJ
cord-312001-8p7scli8	216	37	antiviral	antiviral	JJ
cord-312001-8p7scli8	216	38	immunity	immunity	NN
cord-312001-8p7scli8	216	39	in	in	IN
cord-312001-8p7scli8	216	40	various	various	JJ
cord-312001-8p7scli8	216	41	mosquito	mosquito	NN
cord-312001-8p7scli8	216	42	tissues	tissue	NNS
cord-312001-8p7scli8	216	43	[	[	-LRB-
cord-312001-8p7scli8	216	44	157	157	CD
cord-312001-8p7scli8	216	45	,	,	,
cord-312001-8p7scli8	216	46	158	158	CD
cord-312001-8p7scli8	216	47	]	]	-RRB-
cord-312001-8p7scli8	216	48	.	.	.
cord-312001-8p7scli8	217	1	Although	although	IN
cord-312001-8p7scli8	217	2	the	the	DT
cord-312001-8p7scli8	217	3	pathway	pathway	NN
cord-312001-8p7scli8	217	4	leading	lead	VBG
cord-312001-8p7scli8	217	5	to	to	IN
cord-312001-8p7scli8	217	6	the	the	DT
cord-312001-8p7scli8	217	7	transcriptional	transcriptional	JJ
cord-312001-8p7scli8	217	8	activation	activation	NN
cord-312001-8p7scli8	217	9	of	of	IN
cord-312001-8p7scli8	217	10	Vago	Vago	NNP
cord-312001-8p7scli8	217	11	is	be	VBZ
cord-312001-8p7scli8	217	12	still	still	RB
cord-312001-8p7scli8	217	13	poorly	poorly	RB
cord-312001-8p7scli8	217	14	understood	understand	VBN
cord-312001-8p7scli8	217	15	in	in	IN
cord-312001-8p7scli8	217	16	insects	insect	NNS
cord-312001-8p7scli8	217	17	,	,	,
cord-312001-8p7scli8	217	18	these	these	DT
cord-312001-8p7scli8	217	19	studies	study	NNS
cord-312001-8p7scli8	217	20	established	establish	VBD
cord-312001-8p7scli8	217	21	that	that	IN
cord-312001-8p7scli8	217	22	DExD	DExD	NNS
cord-312001-8p7scli8	217	23	/	/	SYM
cord-312001-8p7scli8	217	24	H	h	NN
cord-312001-8p7scli8	217	25	-	-	HYPH
cord-312001-8p7scli8	217	26	box	box	NN
cord-312001-8p7scli8	217	27	helicase	helicase	NN
cord-312001-8p7scli8	217	28	containing	contain	VBG
cord-312001-8p7scli8	217	29	proteins	protein	NNS
cord-312001-8p7scli8	217	30	,	,	,
cord-312001-8p7scli8	217	31	like	like	IN
cord-312001-8p7scli8	217	32	Dicer	Dicer	NNP
cord-312001-8p7scli8	217	33	and	and	CC
cord-312001-8p7scli8	217	34	RLRs	rlr	NNS
cord-312001-8p7scli8	217	35	,	,	,
cord-312001-8p7scli8	217	36	may	may	MD
cord-312001-8p7scli8	217	37	represent	represent	VB
cord-312001-8p7scli8	217	38	an	an	DT
cord-312001-8p7scli8	217	39	evolutionarily	evolutionarily	RB
cord-312001-8p7scli8	217	40	conserved	conserve	VBN
cord-312001-8p7scli8	217	41	set	set	NN
cord-312001-8p7scli8	217	42	of	of	IN
cord-312001-8p7scli8	217	43	viral	viral	JJ
cord-312001-8p7scli8	217	44	nucleic	nucleic	JJ
cord-312001-8p7scli8	217	45	acid	acid	NN
cord-312001-8p7scli8	217	46	sensors	sensor	NNS
cord-312001-8p7scli8	217	47	that	that	WDT
cord-312001-8p7scli8	217	48	direct	direct	JJ
cord-312001-8p7scli8	217	49	antiviral	antiviral	JJ
cord-312001-8p7scli8	217	50	responses	response	NNS
cord-312001-8p7scli8	217	51	in	in	IN
cord-312001-8p7scli8	217	52	animals	animal	NNS
cord-312001-8p7scli8	217	53	[	[	-LRB-
cord-312001-8p7scli8	217	54	159	159	CD
cord-312001-8p7scli8	217	55	]	]	-RRB-
cord-312001-8p7scli8	217	56	.	.	.
cord-312001-8p7scli8	218	1	One	one	CD
cord-312001-8p7scli8	218	2	last	last	JJ
cord-312001-8p7scli8	218	3	observation	observation	NN
cord-312001-8p7scli8	218	4	exemplifying	exemplify	VBG
cord-312001-8p7scli8	218	5	the	the	DT
cord-312001-8p7scli8	218	6	dynamic	dynamic	JJ
cord-312001-8p7scli8	218	7	and	and	CC
cord-312001-8p7scli8	218	8	rapid	rapid	JJ
cord-312001-8p7scli8	218	9	evolution	evolution	NN
cord-312001-8p7scli8	218	10	of	of	IN
cord-312001-8p7scli8	218	11	these	these	DT
cord-312001-8p7scli8	218	12	receptors	receptor	NNS
cord-312001-8p7scli8	218	13	comes	come	VBZ
cord-312001-8p7scli8	218	14	from	from	IN
cord-312001-8p7scli8	218	15	mammalian	mammalian	JJ
cord-312001-8p7scli8	218	16	species	specie	NNS
cord-312001-8p7scli8	218	17	.	.	.
cord-312001-8p7scli8	219	1	Indeed	indeed	RB
cord-312001-8p7scli8	219	2	,	,	,
cord-312001-8p7scli8	219	3	RLRs	rlr	NNS
cord-312001-8p7scli8	219	4	seem	seem	VBP
cord-312001-8p7scli8	219	5	to	to	TO
cord-312001-8p7scli8	219	6	be	be	VB
cord-312001-8p7scli8	219	7	experiencing	experience	VBG
cord-312001-8p7scli8	219	8	very	very	RB
cord-312001-8p7scli8	219	9	recent	recent	JJ
cord-312001-8p7scli8	219	10	adaptive	adaptive	JJ
cord-312001-8p7scli8	219	11	changes	change	NNS
cord-312001-8p7scli8	219	12	in	in	IN
cord-312001-8p7scli8	219	13	some	some	DT
cord-312001-8p7scli8	219	14	mammals	mammal	NNS
cord-312001-8p7scli8	219	15	.	.	.
cord-312001-8p7scli8	220	1	For	for	IN
cord-312001-8p7scli8	220	2	example	example	NN
cord-312001-8p7scli8	220	3	,	,	,
cord-312001-8p7scli8	220	4	RIG	rig	NN
cord-312001-8p7scli8	220	5	-	-	:
cord-312001-8p7scli8	220	6	I	-PRON-	PRP
cord-312001-8p7scli8	220	7	seems	seem	VBZ
cord-312001-8p7scli8	220	8	to	to	TO
cord-312001-8p7scli8	220	9	have	have	VB
cord-312001-8p7scli8	220	10	accumulated	accumulate	VBN
cord-312001-8p7scli8	220	11	adaptive	adaptive	JJ
cord-312001-8p7scli8	220	12	changes	change	NNS
cord-312001-8p7scli8	220	13	altering	alter	VBG
cord-312001-8p7scli8	220	14	its	-PRON-	PRP$
cord-312001-8p7scli8	220	15	RNA	RNA	NNP
cord-312001-8p7scli8	220	16	-	-	HYPH
cord-312001-8p7scli8	220	17	binding	bind	VBG
cord-312001-8p7scli8	220	18	properties	property	NNS
cord-312001-8p7scli8	220	19	throughout	throughout	IN
cord-312001-8p7scli8	220	20	mammalian	mammalian	JJ
cord-312001-8p7scli8	220	21	evolution	evolution	NN
cord-312001-8p7scli8	220	22	[	[	-LRB-
cord-312001-8p7scli8	220	23	160	160	CD
cord-312001-8p7scli8	220	24	]	]	-RRB-
cord-312001-8p7scli8	220	25	.	.	.
cord-312001-8p7scli8	221	1	Moreover	moreover	RB
cord-312001-8p7scli8	221	2	,	,	,
cord-312001-8p7scli8	221	3	in	in	IN
cord-312001-8p7scli8	221	4	humans	human	NNS
cord-312001-8p7scli8	221	5	,	,	,
cord-312001-8p7scli8	221	6	for	for	IN
cord-312001-8p7scli8	221	7	example	example	NN
cord-312001-8p7scli8	221	8	,	,	,
cord-312001-8p7scli8	221	9	a	a	DT
cord-312001-8p7scli8	221	10	number	number	NN
cord-312001-8p7scli8	221	11	of	of	IN
cord-312001-8p7scli8	221	12	protein	protein	NN
cord-312001-8p7scli8	221	13	-	-	HYPH
cord-312001-8p7scli8	221	14	coding	code	VBG
cord-312001-8p7scli8	221	15	polymorphisms	polymorphism	NNS
cord-312001-8p7scli8	221	16	have	have	VBP
cord-312001-8p7scli8	221	17	been	be	VBN
cord-312001-8p7scli8	221	18	identified	identify	VBN
cord-312001-8p7scli8	221	19	in	in	IN
cord-312001-8p7scli8	221	20	RIG	rig	NN
cord-312001-8p7scli8	221	21	-	-	:
cord-312001-8p7scli8	221	22	I	-PRON-	PRP
cord-312001-8p7scli8	221	23	which	which	WDT
cord-312001-8p7scli8	221	24	may	may	MD
cord-312001-8p7scli8	221	25	contribute	contribute	VB
cord-312001-8p7scli8	221	26	to	to	IN
cord-312001-8p7scli8	221	27	differences	difference	NNS
cord-312001-8p7scli8	221	28	in	in	IN
cord-312001-8p7scli8	221	29	viral	viral	JJ
cord-312001-8p7scli8	221	30	susceptibility	susceptibility	NN
cord-312001-8p7scli8	221	31	and	and	CC
cord-312001-8p7scli8	221	32	risk	risk	NN
cord-312001-8p7scli8	221	33	of	of	IN
cord-312001-8p7scli8	221	34	autoimmune	autoimmune	JJ
cord-312001-8p7scli8	221	35	diseases	disease	NNS
cord-312001-8p7scli8	221	36	[	[	-LRB-
cord-312001-8p7scli8	221	37	14	14	CD
cord-312001-8p7scli8	221	38	,	,	,
cord-312001-8p7scli8	221	39	161	161	CD
cord-312001-8p7scli8	221	40	,	,	,
cord-312001-8p7scli8	221	41	162	162	CD
cord-312001-8p7scli8	221	42	]	]	-RRB-
cord-312001-8p7scli8	221	43	.	.	.
cord-312001-8p7scli8	222	1	STING	sting	VB
cord-312001-8p7scli8	222	2	presence	presence	NN
cord-312001-8p7scli8	222	3	in	in	IN
cord-312001-8p7scli8	222	4	animal	animal	NN
cord-312001-8p7scli8	222	5	genomes	genome	NNS
cord-312001-8p7scli8	222	6	is	be	VBZ
cord-312001-8p7scli8	222	7	probably	probably	RB
cord-312001-8p7scli8	222	8	more	more	RBR
cord-312001-8p7scli8	222	9	ancient	ancient	JJ
cord-312001-8p7scli8	222	10	than	than	IN
cord-312001-8p7scli8	222	11	that	that	DT
cord-312001-8p7scli8	222	12	of	of	IN
cord-312001-8p7scli8	222	13	RLRs	rlr	NNS
cord-312001-8p7scli8	222	14	,	,	,
cord-312001-8p7scli8	222	15	since	since	IN
cord-312001-8p7scli8	222	16	STING	sting	NN
cord-312001-8p7scli8	222	17	homologs	homolog	NNS
cord-312001-8p7scli8	222	18	can	can	MD
cord-312001-8p7scli8	222	19	be	be	VB
cord-312001-8p7scli8	222	20	found	find	VBN
cord-312001-8p7scli8	222	21	in	in	IN
cord-312001-8p7scli8	222	22	most	most	JJS
cord-312001-8p7scli8	222	23	animal	animal	NN
cord-312001-8p7scli8	222	24	phyla	phylum	NNS
cord-312001-8p7scli8	222	25	including	include	VBG
cord-312001-8p7scli8	222	26	unicellular	unicellular	JJ
cord-312001-8p7scli8	222	27	choanoflagellates	choanoflagellate	NNS
cord-312001-8p7scli8	222	28	(	(	-LRB-
cord-312001-8p7scli8	222	29	Figure	figure	NN
cord-312001-8p7scli8	222	30	2	2	CD
cord-312001-8p7scli8	222	31	)	)	-RRB-
cord-312001-8p7scli8	222	32	[	[	-LRB-
cord-312001-8p7scli8	222	33	12	12	CD
cord-312001-8p7scli8	222	34	,	,	,
cord-312001-8p7scli8	222	35	163	163	CD
cord-312001-8p7scli8	222	36	]	]	-RRB-
cord-312001-8p7scli8	222	37	.	.	.
cord-312001-8p7scli8	223	1	Furthermore	furthermore	RB
cord-312001-8p7scli8	223	2	,	,	,
cord-312001-8p7scli8	223	3	the	the	DT
cord-312001-8p7scli8	223	4	ability	ability	NN
cord-312001-8p7scli8	223	5	of	of	IN
cord-312001-8p7scli8	223	6	STING	sting	NN
cord-312001-8p7scli8	223	7	to	to	TO
cord-312001-8p7scli8	223	8	bind	bind	VB
cord-312001-8p7scli8	223	9	CDNs	CDNs	NNP
cord-312001-8p7scli8	223	10	seems	seem	VBZ
cord-312001-8p7scli8	223	11	to	to	TO
cord-312001-8p7scli8	223	12	be	be	VB
cord-312001-8p7scli8	223	13	an	an	DT
cord-312001-8p7scli8	223	14	ancient	ancient	JJ
cord-312001-8p7scli8	223	15	property	property	NN
cord-312001-8p7scli8	223	16	.	.	.
cord-312001-8p7scli8	224	1	In	in	IN
cord-312001-8p7scli8	224	2	an	an	DT
cord-312001-8p7scli8	224	3	elegant	elegant	JJ
cord-312001-8p7scli8	224	4	study	study	NN
cord-312001-8p7scli8	224	5	,	,	,
cord-312001-8p7scli8	224	6	Kranzusch	Kranzusch	NNP
cord-312001-8p7scli8	224	7	and	and	CC
cord-312001-8p7scli8	224	8	colleagues	colleague	NNS
cord-312001-8p7scli8	224	9	show	show	VBP
cord-312001-8p7scli8	224	10	that	that	IN
cord-312001-8p7scli8	224	11	a	a	DT
cord-312001-8p7scli8	224	12	STING	sting	NN
cord-312001-8p7scli8	224	13	homolog	homolog	NN
cord-312001-8p7scli8	224	14	in	in	IN
cord-312001-8p7scli8	224	15	the	the	DT
cord-312001-8p7scli8	224	16	starlet	starlet	NN
cord-312001-8p7scli8	224	17	sea	sea	NN
cord-312001-8p7scli8	224	18	anemone	anemone	NN
cord-312001-8p7scli8	224	19	N.	N.	NNP
cord-312001-8p7scli8	224	20	vectensis	vectensis	NN
cord-312001-8p7scli8	224	21	(	(	-LRB-
cord-312001-8p7scli8	224	22	nvSTING	nvSTING	NNP
cord-312001-8p7scli8	224	23	)	)	-RRB-
cord-312001-8p7scli8	224	24	is	be	VBZ
cord-312001-8p7scli8	224	25	not	not	RB
cord-312001-8p7scli8	224	26	only	only	RB
cord-312001-8p7scli8	224	27	structurally	structurally	RB
cord-312001-8p7scli8	224	28	very	very	RB
cord-312001-8p7scli8	224	29	similar	similar	JJ
cord-312001-8p7scli8	224	30	to	to	IN
cord-312001-8p7scli8	224	31	that	that	DT
cord-312001-8p7scli8	224	32	of	of	IN
cord-312001-8p7scli8	224	33	human	human	JJ
cord-312001-8p7scli8	224	34	STING	sting	NN
cord-312001-8p7scli8	224	35	but	but	CC
cord-312001-8p7scli8	224	36	is	be	VBZ
cord-312001-8p7scli8	224	37	also	also	RB
cord-312001-8p7scli8	224	38	able	able	JJ
cord-312001-8p7scli8	224	39	to	to	TO
cord-312001-8p7scli8	224	40	bind	bind	VB
cord-312001-8p7scli8	224	41	2	2	CD
cord-312001-8p7scli8	224	42	3	3	CD
cord-312001-8p7scli8	224	43	cGAMP	cGAMP	NNS
cord-312001-8p7scli8	224	44	with	with	IN
cord-312001-8p7scli8	224	45	very	very	RB
cord-312001-8p7scli8	224	46	high	high	JJ
cord-312001-8p7scli8	224	47	affinity	affinity	NN
cord-312001-8p7scli8	224	48	[	[	-LRB-
cord-312001-8p7scli8	224	49	13	13	CD
cord-312001-8p7scli8	224	50	]	]	-RRB-
cord-312001-8p7scli8	224	51	.	.	.
cord-312001-8p7scli8	225	1	However	however	RB
cord-312001-8p7scli8	225	2	,	,	,
cord-312001-8p7scli8	225	3	STING	STING	NNP
cord-312001-8p7scli8	225	4	's	's	POS
cord-312001-8p7scli8	225	5	CTT	CTT	NNP
cord-312001-8p7scli8	225	6	domain	domain	NN
cord-312001-8p7scli8	225	7	,	,	,
cord-312001-8p7scli8	225	8	which	which	WDT
cord-312001-8p7scli8	225	9	is	be	VBZ
cord-312001-8p7scli8	225	10	crucial	crucial	JJ
cord-312001-8p7scli8	225	11	for	for	IN
cord-312001-8p7scli8	225	12	TBK1	TBK1	NNP
cord-312001-8p7scli8	225	13	recruitment	recruitment	NN
cord-312001-8p7scli8	225	14	and	and	CC
cord-312001-8p7scli8	225	15	downstream	downstream	JJ
cord-312001-8p7scli8	225	16	IFN	IFN	NNP
cord-312001-8p7scli8	225	17	induction	induction	NN
cord-312001-8p7scli8	225	18	,	,	,
cord-312001-8p7scli8	225	19	appeared	appear	VBD
cord-312001-8p7scli8	225	20	only	only	RB
cord-312001-8p7scli8	225	21	in	in	IN
cord-312001-8p7scli8	225	22	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	225	23	species	specie	NNS
cord-312001-8p7scli8	225	24	[	[	-LRB-
cord-312001-8p7scli8	225	25	164	164	CD
cord-312001-8p7scli8	225	26	]	]	-RRB-
cord-312001-8p7scli8	225	27	.	.	.
cord-312001-8p7scli8	226	1	Consequently	consequently	RB
cord-312001-8p7scli8	226	2	,	,	,
cord-312001-8p7scli8	226	3	nvSTING	nvsting	DT
cord-312001-8p7scli8	226	4	lacking	lack	VBG
cord-312001-8p7scli8	226	5	the	the	DT
cord-312001-8p7scli8	226	6	CTT	CTT	NNP
cord-312001-8p7scli8	226	7	is	be	VBZ
cord-312001-8p7scli8	226	8	unable	unable	JJ
cord-312001-8p7scli8	226	9	to	to	TO
cord-312001-8p7scli8	226	10	induce	induce	VB
cord-312001-8p7scli8	226	11	IFN	IFN	NNP
cord-312001-8p7scli8	226	12	-	-	HYPH
cord-312001-8p7scli8	226	13	β	β	NN
cord-312001-8p7scli8	226	14	production	production	NN
cord-312001-8p7scli8	226	15	in	in	IN
cord-312001-8p7scli8	226	16	response	response	NN
cord-312001-8p7scli8	226	17	to	to	IN
cord-312001-8p7scli8	226	18	CDNs	CDNs	NNP
cord-312001-8p7scli8	226	19	when	when	WRB
cord-312001-8p7scli8	226	20	transfected	transfecte	VBN
cord-312001-8p7scli8	226	21	in	in	IN
cord-312001-8p7scli8	226	22	mammalian	mammalian	JJ
cord-312001-8p7scli8	226	23	cells	cell	NNS
cord-312001-8p7scli8	226	24	[	[	-LRB-
cord-312001-8p7scli8	226	25	13	13	CD
cord-312001-8p7scli8	226	26	]	]	-RRB-
cord-312001-8p7scli8	226	27	.	.	.
cord-312001-8p7scli8	227	1	The	the	DT
cord-312001-8p7scli8	227	2	lack	lack	NN
cord-312001-8p7scli8	227	3	of	of	IN
cord-312001-8p7scli8	227	4	a	a	DT
cord-312001-8p7scli8	227	5	CTT	CTT	NNP
cord-312001-8p7scli8	227	6	domain	domain	NN
cord-312001-8p7scli8	227	7	in	in	IN
cord-312001-8p7scli8	227	8	invertebrates	invertebrate	NNS
cord-312001-8p7scli8	227	9	does	do	VBZ
cord-312001-8p7scli8	227	10	not	not	RB
cord-312001-8p7scli8	227	11	mean	mean	VB
cord-312001-8p7scli8	227	12	that	that	IN
cord-312001-8p7scli8	227	13	STING	sting	NN
cord-312001-8p7scli8	227	14	could	could	MD
cord-312001-8p7scli8	227	15	not	not	RB
cord-312001-8p7scli8	227	16	have	have	VB
cord-312001-8p7scli8	227	17	an	an	DT
cord-312001-8p7scli8	227	18	immune	immune	JJ
cord-312001-8p7scli8	227	19	function	function	NN
cord-312001-8p7scli8	227	20	in	in	IN
cord-312001-8p7scli8	227	21	these	these	DT
cord-312001-8p7scli8	227	22	animals	animal	NNS
cord-312001-8p7scli8	227	23	.	.	.
cord-312001-8p7scli8	228	1	A	a	DT
cord-312001-8p7scli8	228	2	first	first	JJ
cord-312001-8p7scli8	228	3	indication	indication	NN
cord-312001-8p7scli8	228	4	comes	come	VBZ
cord-312001-8p7scli8	228	5	from	from	IN
cord-312001-8p7scli8	228	6	invertebrate	invertebrate	JJ
cord-312001-8p7scli8	228	7	species	specie	NNS
cord-312001-8p7scli8	228	8	like	like	IN
cord-312001-8p7scli8	228	9	the	the	DT
cord-312001-8p7scli8	228	10	Lophotrochozoa	Lophotrochozoa	NNP
cord-312001-8p7scli8	228	11	phylum	phylum	NN
cord-312001-8p7scli8	228	12	that	that	WDT
cord-312001-8p7scli8	228	13	includes	include	VBZ
cord-312001-8p7scli8	228	14	the	the	DT
cord-312001-8p7scli8	228	15	pacific	pacific	NNP
cord-312001-8p7scli8	228	16	oyster	oyster	NN
cord-312001-8p7scli8	228	17	C.	C.	NNP
cord-312001-8p7scli8	228	18	gigas	gigas	NNP
cord-312001-8p7scli8	228	19	and	and	CC
cord-312001-8p7scli8	228	20	the	the	DT
cord-312001-8p7scli8	228	21	annelid	annelid	NN
cord-312001-8p7scli8	228	22	worm	worm	NN
cord-312001-8p7scli8	228	23	Capitella	Capitella	NNP
cord-312001-8p7scli8	228	24	teleta	teleta	RB
cord-312001-8p7scli8	228	25	.	.	.
cord-312001-8p7scli8	229	1	In	in	IN
cord-312001-8p7scli8	229	2	these	these	DT
cord-312001-8p7scli8	229	3	animals	animal	NNS
cord-312001-8p7scli8	229	4	,	,	,
cord-312001-8p7scli8	229	5	an	an	DT
cord-312001-8p7scli8	229	6	unusual	unusual	JJ
cord-312001-8p7scli8	229	7	STING	sting	NN
cord-312001-8p7scli8	229	8	architecture	architecture	NN
cord-312001-8p7scli8	229	9	can	can	MD
cord-312001-8p7scli8	229	10	be	be	VB
cord-312001-8p7scli8	229	11	found	find	VBN
cord-312001-8p7scli8	229	12	,	,	,
cord-312001-8p7scli8	229	13	where	where	WRB
cord-312001-8p7scli8	229	14	a	a	DT
cord-312001-8p7scli8	229	15	STING	sting	NN
cord-312001-8p7scli8	229	16	domain	domain	NN
cord-312001-8p7scli8	229	17	is	be	VBZ
cord-312001-8p7scli8	229	18	fused	fuse	VBN
cord-312001-8p7scli8	229	19	to	to	IN
cord-312001-8p7scli8	229	20	a	a	DT
cord-312001-8p7scli8	229	21	TIR	TIR	NNP
cord-312001-8p7scli8	229	22	domain	domain	NN
cord-312001-8p7scli8	229	23	,	,	,
cord-312001-8p7scli8	229	24	known	know	VBN
cord-312001-8p7scli8	229	25	to	to	TO
cord-312001-8p7scli8	229	26	be	be	VB
cord-312001-8p7scli8	229	27	involved	involve	VBN
cord-312001-8p7scli8	229	28	in	in	IN
cord-312001-8p7scli8	229	29	innate	innate	JJ
cord-312001-8p7scli8	229	30	immune	immune	NN
cord-312001-8p7scli8	229	31	signaling	signal	VBG
cord-312001-8p7scli8	229	32	[	[	-LRB-
cord-312001-8p7scli8	229	33	164	164	CD
cord-312001-8p7scli8	229	34	,	,	,
cord-312001-8p7scli8	229	35	165	165	CD
cord-312001-8p7scli8	229	36	]	]	-RRB-
cord-312001-8p7scli8	229	37	.	.	.
cord-312001-8p7scli8	230	1	The	the	DT
cord-312001-8p7scli8	230	2	second	second	JJ
cord-312001-8p7scli8	230	3	indication	indication	NN
cord-312001-8p7scli8	230	4	that	that	IN
cord-312001-8p7scli8	230	5	STING	sting	NN
cord-312001-8p7scli8	230	6	lacking	lack	VBG
cord-312001-8p7scli8	230	7	a	a	DT
cord-312001-8p7scli8	230	8	CTT	CTT	NNP
cord-312001-8p7scli8	230	9	could	could	MD
cord-312001-8p7scli8	230	10	function	function	VB
cord-312001-8p7scli8	230	11	in	in	IN
cord-312001-8p7scli8	230	12	immunity	immunity	NN
cord-312001-8p7scli8	230	13	comes	come	VBZ
cord-312001-8p7scli8	230	14	from	from	IN
cord-312001-8p7scli8	230	15	arthropods	arthropod	NNS
cord-312001-8p7scli8	230	16	.	.	.
cord-312001-8p7scli8	231	1	Recent	recent	JJ
cord-312001-8p7scli8	231	2	studies	study	NNS
cord-312001-8p7scli8	231	3	in	in	IN
cord-312001-8p7scli8	231	4	Drosophila	Drosophila	NNP
cord-312001-8p7scli8	231	5	,	,	,
cord-312001-8p7scli8	231	6	that	that	WDT
cord-312001-8p7scli8	231	7	lack	lack	VBP
cord-312001-8p7scli8	231	8	an	an	DT
cord-312001-8p7scli8	231	9	IFN	IFN	NNP
cord-312001-8p7scli8	231	10	system	system	NN
cord-312001-8p7scli8	231	11	,	,	,
cord-312001-8p7scli8	231	12	clearly	clearly	RB
cord-312001-8p7scli8	231	13	show	show	VBP
cord-312001-8p7scli8	231	14	that	that	IN
cord-312001-8p7scli8	231	15	STING	sting	NN
cord-312001-8p7scli8	231	16	is	be	VBZ
cord-312001-8p7scli8	231	17	important	important	JJ
cord-312001-8p7scli8	231	18	for	for	IN
cord-312001-8p7scli8	231	19	antimicrobial	antimicrobial	JJ
cord-312001-8p7scli8	231	20	and	and	CC
cord-312001-8p7scli8	231	21	antiviral	antiviral	JJ
cord-312001-8p7scli8	231	22	NF	NF	NNP
cord-312001-8p7scli8	231	23	-	-	HYPH
cord-312001-8p7scli8	231	24	kB	kb	CD
cord-312001-8p7scli8	231	25	activation	activation	NN
cord-312001-8p7scli8	231	26	in	in	IN
cord-312001-8p7scli8	231	27	this	this	DT
cord-312001-8p7scli8	231	28	model	model	NN
cord-312001-8p7scli8	231	29	[	[	-LRB-
cord-312001-8p7scli8	231	30	151	151	CD
cord-312001-8p7scli8	231	31	,	,	,
cord-312001-8p7scli8	231	32	166	166	CD
cord-312001-8p7scli8	231	33	]	]	-RRB-
cord-312001-8p7scli8	232	1	(	(	-LRB-
cord-312001-8p7scli8	232	2	Figure	figure	NN
cord-312001-8p7scli8	232	3	2	2	CD
cord-312001-8p7scli8	232	4	)	)	-RRB-
cord-312001-8p7scli8	232	5	.	.	.
cord-312001-8p7scli8	233	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	233	2	,	,	,
cord-312001-8p7scli8	233	3	the	the	DT
cord-312001-8p7scli8	233	4	emergence	emergence	NN
cord-312001-8p7scli8	233	5	of	of	IN
cord-312001-8p7scli8	233	6	the	the	DT
cord-312001-8p7scli8	233	7	CTT	CTT	NNP
cord-312001-8p7scli8	233	8	domain	domain	NN
cord-312001-8p7scli8	233	9	of	of	IN
cord-312001-8p7scli8	233	10	STING	sting	NN
cord-312001-8p7scli8	233	11	in	in	IN
cord-312001-8p7scli8	233	12	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	233	13	species	specie	NNS
cord-312001-8p7scli8	233	14	seems	seem	VBZ
cord-312001-8p7scli8	233	15	to	to	TO
cord-312001-8p7scli8	233	16	coincide	coincide	VB
cord-312001-8p7scli8	233	17	with	with	IN
cord-312001-8p7scli8	233	18	the	the	DT
cord-312001-8p7scli8	233	19	development	development	NN
cord-312001-8p7scli8	233	20	of	of	IN
cord-312001-8p7scli8	233	21	the	the	DT
cord-312001-8p7scli8	233	22	IFN	IFN	NNP
cord-312001-8p7scli8	233	23	system	system	NN
cord-312001-8p7scli8	233	24	.	.	.
cord-312001-8p7scli8	234	1	Nevertheless	nevertheless	RB
cord-312001-8p7scli8	234	2	,	,	,
cord-312001-8p7scli8	234	3	STING	STING	NNP
cord-312001-8p7scli8	234	4	CTT	CTT	NNP
cord-312001-8p7scli8	234	5	domain	domain	NN
cord-312001-8p7scli8	234	6	function	function	NN
cord-312001-8p7scli8	234	7	,	,	,
cord-312001-8p7scli8	234	8	which	which	WDT
cord-312001-8p7scli8	234	9	dictates	dictate	VBZ
cord-312001-8p7scli8	234	10	downstream	downstream	JJ
cord-312001-8p7scli8	234	11	signaling	signaling	NN
cord-312001-8p7scli8	234	12	,	,	,
cord-312001-8p7scli8	234	13	seems	seem	VBZ
cord-312001-8p7scli8	234	14	to	to	TO
cord-312001-8p7scli8	234	15	be	be	VB
cord-312001-8p7scli8	234	16	plastic	plastic	NN
cord-312001-8p7scli8	234	17	amongst	amongst	IN
cord-312001-8p7scli8	234	18	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	234	19	species	specie	NNS
cord-312001-8p7scli8	234	20	.	.	.
cord-312001-8p7scli8	235	1	In	in	IN
cord-312001-8p7scli8	235	2	a	a	DT
cord-312001-8p7scli8	235	3	recent	recent	JJ
cord-312001-8p7scli8	235	4	study	study	NN
cord-312001-8p7scli8	235	5	,	,	,
cord-312001-8p7scli8	235	6	authors	author	NNS
cord-312001-8p7scli8	235	7	show	show	VBP
cord-312001-8p7scli8	235	8	that	that	IN
cord-312001-8p7scli8	235	9	STING	STING	NNP
cord-312001-8p7scli8	235	10	CTT	CTT	NNP
cord-312001-8p7scli8	235	11	-	-	HYPH
cord-312001-8p7scli8	235	12	dependent	dependent	JJ
cord-312001-8p7scli8	235	13	activation	activation	NN
cord-312001-8p7scli8	235	14	of	of	IN
cord-312001-8p7scli8	235	15	IRF3	IRF3	NNP
cord-312001-8p7scli8	235	16	and	and	CC
cord-312001-8p7scli8	235	17	NF	NF	NNP
cord-312001-8p7scli8	235	18	-	-	HYPH
cord-312001-8p7scli8	235	19	kB	kB	NNP
cord-312001-8p7scli8	235	20	varies	vary	VBZ
cord-312001-8p7scli8	235	21	between	between	IN
cord-312001-8p7scli8	235	22	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	235	23	species	specie	NNS
cord-312001-8p7scli8	235	24	[	[	-LRB-
cord-312001-8p7scli8	235	25	167	167	CD
cord-312001-8p7scli8	235	26	]	]	-RRB-
cord-312001-8p7scli8	235	27	.	.	.
cord-312001-8p7scli8	236	1	While	while	IN
cord-312001-8p7scli8	236	2	STING	STING	NNP
cord-312001-8p7scli8	236	3	CTT	CTT	NNP
cord-312001-8p7scli8	236	4	from	from	IN
cord-312001-8p7scli8	236	5	mammalian	mammalian	JJ
cord-312001-8p7scli8	236	6	species	specie	NNS
cord-312001-8p7scli8	236	7	is	be	VBZ
cord-312001-8p7scli8	236	8	able	able	JJ
cord-312001-8p7scli8	236	9	to	to	TO
cord-312001-8p7scli8	236	10	induce	induce	VB
cord-312001-8p7scli8	236	11	a	a	DT
cord-312001-8p7scli8	236	12	strong	strong	JJ
cord-312001-8p7scli8	236	13	IFN	IFN	NNP
cord-312001-8p7scli8	236	14	-	-	HYPH
cord-312001-8p7scli8	236	15	β	β	NNP
cord-312001-8p7scli8	236	16	and	and	CC
cord-312001-8p7scli8	236	17	a	a	DT
cord-312001-8p7scli8	236	18	weaker	weak	JJR
cord-312001-8p7scli8	236	19	NF	nf	NN
cord-312001-8p7scli8	236	20	-	-	HYPH
cord-312001-8p7scli8	236	21	kB	kb	CD
cord-312001-8p7scli8	236	22	response	response	NN
cord-312001-8p7scli8	236	23	,	,	,
cord-312001-8p7scli8	236	24	an	an	DT
cord-312001-8p7scli8	236	25	extension	extension	NN
cord-312001-8p7scli8	236	26	of	of	IN
cord-312001-8p7scli8	236	27	this	this	DT
cord-312001-8p7scli8	236	28	domain	domain	NN
cord-312001-8p7scli8	236	29	in	in	IN
cord-312001-8p7scli8	236	30	ray	ray	NN
cord-312001-8p7scli8	236	31	-	-	HYPH
cord-312001-8p7scli8	236	32	finned	finned	JJ
cord-312001-8p7scli8	236	33	fish	fish	NN
cord-312001-8p7scli8	236	34	species	species	NN
cord-312001-8p7scli8	236	35	elicits	elicit	VBZ
cord-312001-8p7scli8	236	36	a	a	DT
cord-312001-8p7scli8	236	37	dramatic	dramatic	JJ
cord-312001-8p7scli8	236	38	enhancement	enhancement	NN
cord-312001-8p7scli8	236	39	of	of	IN
cord-312001-8p7scli8	236	40	NF	NF	NNP
cord-312001-8p7scli8	236	41	-	-	HYPH
cord-312001-8p7scli8	236	42	kB	kb	CD
cord-312001-8p7scli8	236	43	activation	activation	NN
cord-312001-8p7scli8	236	44	and	and	CC
cord-312001-8p7scli8	236	45	weaker	weak	JJR
cord-312001-8p7scli8	236	46	IRF3-IFN	IRF3-IFN	NNP
cord-312001-8p7scli8	236	47	signaling	signal	VBG
cord-312001-8p7scli8	236	48	[	[	-LRB-
cord-312001-8p7scli8	236	49	167	167	CD
cord-312001-8p7scli8	236	50	]	]	-RRB-
cord-312001-8p7scli8	236	51	.	.	.
cord-312001-8p7scli8	237	1	Another	another	DT
cord-312001-8p7scli8	237	2	indication	indication	NN
cord-312001-8p7scli8	237	3	of	of	IN
cord-312001-8p7scli8	237	4	STING	STING	NNP
cord-312001-8p7scli8	237	5	CTT	CTT	NNP
cord-312001-8p7scli8	237	6	structure	structure	NN
cord-312001-8p7scli8	237	7	-	-	HYPH
cord-312001-8p7scli8	237	8	function	function	NN
cord-312001-8p7scli8	237	9	plasticity	plasticity	NN
cord-312001-8p7scli8	237	10	comes	come	VBZ
cord-312001-8p7scli8	237	11	from	from	IN
cord-312001-8p7scli8	237	12	bat	bat	NN
cord-312001-8p7scli8	237	13	species	specie	NNS
cord-312001-8p7scli8	237	14	.	.	.
cord-312001-8p7scli8	238	1	A	a	DT
cord-312001-8p7scli8	238	2	highly	highly	RB
cord-312001-8p7scli8	238	3	conserved	conserved	JJ
cord-312001-8p7scli8	238	4	and	and	CC
cord-312001-8p7scli8	238	5	functionally	functionally	RB
cord-312001-8p7scli8	238	6	important	important	JJ
cord-312001-8p7scli8	238	7	serine	serine	NN
cord-312001-8p7scli8	238	8	residue	residue	NN
cord-312001-8p7scli8	238	9	(	(	-LRB-
cord-312001-8p7scli8	238	10	S358	S358	NNP
cord-312001-8p7scli8	238	11	)	)	-RRB-
cord-312001-8p7scli8	238	12	in	in	IN
cord-312001-8p7scli8	238	13	STING	STING	NNP
cord-312001-8p7scli8	238	14	's	's	POS
cord-312001-8p7scli8	238	15	CTT	CTT	NNP
cord-312001-8p7scli8	238	16	domain	domain	NN
cord-312001-8p7scli8	238	17	is	be	VBZ
cord-312001-8p7scli8	238	18	lost	lose	VBN
cord-312001-8p7scli8	238	19	in	in	IN
cord-312001-8p7scli8	238	20	bats	bat	NNS
cord-312001-8p7scli8	238	21	[	[	-LRB-
cord-312001-8p7scli8	238	22	168	168	CD
cord-312001-8p7scli8	238	23	]	]	-RRB-
cord-312001-8p7scli8	238	24	.	.	.
cord-312001-8p7scli8	239	1	The	the	DT
cord-312001-8p7scli8	239	2	replacement	replacement	NN
cord-312001-8p7scli8	239	3	of	of	IN
cord-312001-8p7scli8	239	4	this	this	DT
cord-312001-8p7scli8	239	5	critical	critical	JJ
cord-312001-8p7scli8	239	6	residue	residue	NN
cord-312001-8p7scli8	239	7	in	in	IN
cord-312001-8p7scli8	239	8	this	this	DT
cord-312001-8p7scli8	239	9	mammalian	mammalian	JJ
cord-312001-8p7scli8	239	10	species	specie	NNS
cord-312001-8p7scli8	239	11	significantly	significantly	RB
cord-312001-8p7scli8	239	12	dampens	dampen	VBZ
cord-312001-8p7scli8	239	13	STING	sting	NN
cord-312001-8p7scli8	239	14	-	-	HYPH
cord-312001-8p7scli8	239	15	dependent	dependent	JJ
cord-312001-8p7scli8	239	16	IFN	IFN	NNP
cord-312001-8p7scli8	239	17	activation	activation	NN
cord-312001-8p7scli8	239	18	.	.	.
cord-312001-8p7scli8	240	1	The	the	DT
cord-312001-8p7scli8	240	2	authors	author	NNS
cord-312001-8p7scli8	240	3	of	of	IN
cord-312001-8p7scli8	240	4	this	this	DT
cord-312001-8p7scli8	240	5	study	study	NN
cord-312001-8p7scli8	240	6	suggest	suggest	VBP
cord-312001-8p7scli8	240	7	that	that	IN
cord-312001-8p7scli8	240	8	the	the	DT
cord-312001-8p7scli8	240	9	lifestyle	lifestyle	NN
cord-312001-8p7scli8	240	10	of	of	IN
cord-312001-8p7scli8	240	11	bat	bat	NN
cord-312001-8p7scli8	240	12	species	specie	NNS
cord-312001-8p7scli8	240	13	(	(	-LRB-
cord-312001-8p7scli8	240	14	e.g.	e.g.	RB
cord-312001-8p7scli8	240	15	,	,	,
cord-312001-8p7scli8	240	16	flight	flight	NN
cord-312001-8p7scli8	240	17	induced	induce	VBN
cord-312001-8p7scli8	240	18	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	240	19	DNA	dna	NN
cord-312001-8p7scli8	240	20	,	,	,
cord-312001-8p7scli8	240	21	high	high	JJ
cord-312001-8p7scli8	240	22	viral	viral	JJ
cord-312001-8p7scli8	240	23	titers	titer	NNS
cord-312001-8p7scli8	240	24	)	)	-RRB-
cord-312001-8p7scli8	240	25	imposes	impose	VBZ
cord-312001-8p7scli8	240	26	a	a	DT
cord-312001-8p7scli8	240	27	strong	strong	JJ
cord-312001-8p7scli8	240	28	selective	selective	JJ
cord-312001-8p7scli8	240	29	pressure	pressure	NN
cord-312001-8p7scli8	240	30	on	on	IN
cord-312001-8p7scli8	240	31	STING	sting	NN
cord-312001-8p7scli8	240	32	.	.	.
cord-312001-8p7scli8	241	1	This	this	DT
cord-312001-8p7scli8	241	2	results	result	VBZ
cord-312001-8p7scli8	241	3	in	in	IN
cord-312001-8p7scli8	241	4	functionally	functionally	RB
cord-312001-8p7scli8	241	5	dampened	dampened	JJ
cord-312001-8p7scli8	241	6	sensing	sensing	NN
cord-312001-8p7scli8	241	7	and	and	CC
cord-312001-8p7scli8	241	8	signaling	signal	VBG
cord-312001-8p7scli8	241	9	mechanisms	mechanism	NNS
cord-312001-8p7scli8	241	10	to	to	TO
cord-312001-8p7scli8	241	11	avoid	avoid	VB
cord-312001-8p7scli8	241	12	IFN	IFN	NNP
cord-312001-8p7scli8	241	13	overactivation	overactivation	NN
cord-312001-8p7scli8	241	14	and	and	CC
cord-312001-8p7scli8	241	15	to	to	TO
cord-312001-8p7scli8	241	16	cope	cope	VB
cord-312001-8p7scli8	241	17	with	with	IN
cord-312001-8p7scli8	241	18	high	high	JJ
cord-312001-8p7scli8	241	19	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	241	20	DNA	dna	NN
cord-312001-8p7scli8	241	21	content	content	NN
cord-312001-8p7scli8	241	22	.	.	.
cord-312001-8p7scli8	242	1	Taken	take	VBN
cord-312001-8p7scli8	242	2	together	together	RB
cord-312001-8p7scli8	242	3	,	,	,
cord-312001-8p7scli8	242	4	present	present	JJ
cord-312001-8p7scli8	242	5	studies	study	NNS
cord-312001-8p7scli8	242	6	suggest	suggest	VBP
cord-312001-8p7scli8	242	7	an	an	DT
cord-312001-8p7scli8	242	8	evolutionarily	evolutionarily	RB
cord-312001-8p7scli8	242	9	ancient	ancient	JJ
cord-312001-8p7scli8	242	10	role	role	NN
cord-312001-8p7scli8	242	11	of	of	IN
cord-312001-8p7scli8	242	12	STING	sting	NN
cord-312001-8p7scli8	242	13	in	in	IN
cord-312001-8p7scli8	242	14	antiviral	antiviral	JJ
cord-312001-8p7scli8	242	15	immunity	immunity	NN
cord-312001-8p7scli8	242	16	and	and	CC
cord-312001-8p7scli8	242	17	modulation	modulation	NN
cord-312001-8p7scli8	242	18	of	of	IN
cord-312001-8p7scli8	242	19	its	-PRON-	PRP$
cord-312001-8p7scli8	242	20	structure	structure	NN
cord-312001-8p7scli8	242	21	and	and	CC
cord-312001-8p7scli8	242	22	function	function	NN
cord-312001-8p7scli8	242	23	to	to	TO
cord-312001-8p7scli8	242	24	accommodate	accommodate	VB
cord-312001-8p7scli8	242	25	species	species	NN
cord-312001-8p7scli8	242	26	-	-	HYPH
cord-312001-8p7scli8	242	27	specific	specific	JJ
cord-312001-8p7scli8	242	28	pathogen	pathogen	NN
cord-312001-8p7scli8	242	29	burdens	burden	NNS
cord-312001-8p7scli8	242	30	.	.	.
cord-312001-8p7scli8	243	1	The	the	DT
cord-312001-8p7scli8	243	2	picture	picture	NN
cord-312001-8p7scli8	243	3	is	be	VBZ
cord-312001-8p7scli8	243	4	less	less	RBR
cord-312001-8p7scli8	243	5	clear	clear	JJ
cord-312001-8p7scli8	243	6	for	for	IN
cord-312001-8p7scli8	243	7	the	the	DT
cord-312001-8p7scli8	243	8	cGAS	cgas	JJ
cord-312001-8p7scli8	243	9	enzyme	enzyme	NN
cord-312001-8p7scli8	243	10	when	when	WRB
cord-312001-8p7scli8	243	11	it	-PRON-	PRP
cord-312001-8p7scli8	243	12	comes	come	VBZ
cord-312001-8p7scli8	243	13	to	to	IN
cord-312001-8p7scli8	243	14	antiviral	antiviral	JJ
cord-312001-8p7scli8	243	15	immunity	immunity	NN
cord-312001-8p7scli8	243	16	.	.	.
cord-312001-8p7scli8	244	1	Although	although	IN
cord-312001-8p7scli8	244	2	cGAS	cgas	JJ
cord-312001-8p7scli8	244	3	homologs	homolog	NNS
cord-312001-8p7scli8	244	4	have	have	VBP
cord-312001-8p7scli8	244	5	been	be	VBN
cord-312001-8p7scli8	244	6	identified	identify	VBN
cord-312001-8p7scli8	244	7	in	in	IN
cord-312001-8p7scli8	244	8	a	a	DT
cord-312001-8p7scli8	244	9	variety	variety	NN
cord-312001-8p7scli8	244	10	of	of	IN
cord-312001-8p7scli8	244	11	ancient	ancient	JJ
cord-312001-8p7scli8	244	12	metazoan	metazoan	NN
cord-312001-8p7scli8	244	13	lineages	lineage	NNS
cord-312001-8p7scli8	244	14	[	[	-LRB-
cord-312001-8p7scli8	244	15	12	12	CD
cord-312001-8p7scli8	244	16	,	,	,
cord-312001-8p7scli8	244	17	163	163	CD
cord-312001-8p7scli8	244	18	]	]	-RRB-
cord-312001-8p7scli8	244	19	,	,	,
cord-312001-8p7scli8	244	20	it	-PRON-	PRP
cord-312001-8p7scli8	244	21	is	be	VBZ
cord-312001-8p7scli8	244	22	believed	believe	VBN
cord-312001-8p7scli8	244	23	that	that	IN
cord-312001-8p7scli8	244	24	the	the	DT
cord-312001-8p7scli8	244	25	ability	ability	NN
cord-312001-8p7scli8	244	26	of	of	IN
cord-312001-8p7scli8	244	27	cGAS	cgas	NN
cord-312001-8p7scli8	244	28	to	to	TO
cord-312001-8p7scli8	244	29	bind	bind	VB
cord-312001-8p7scli8	244	30	and	and	CC
cord-312001-8p7scli8	244	31	detect	detect	VB
cord-312001-8p7scli8	244	32	dsDNA	dsdna	RB
cord-312001-8p7scli8	244	33	emerged	emerge	VBN
cord-312001-8p7scli8	244	34	in	in	IN
cord-312001-8p7scli8	244	35	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	244	36	.	.	.
cord-312001-8p7scli8	245	1	Indeed	indeed	RB
cord-312001-8p7scli8	245	2	,	,	,
cord-312001-8p7scli8	245	3	cGAS	cga	VBG
cord-312001-8p7scli8	245	4	'	'	''
cord-312001-8p7scli8	245	5	zinc	zinc	NN
cord-312001-8p7scli8	245	6	-	-	HYPH
cord-312001-8p7scli8	245	7	ribbon	ribbon	NN
cord-312001-8p7scli8	245	8	domain	domain	NN
cord-312001-8p7scli8	245	9	,	,	,
cord-312001-8p7scli8	245	10	required	require	VBN
cord-312001-8p7scli8	245	11	for	for	IN
cord-312001-8p7scli8	245	12	DNA	dna	NN
cord-312001-8p7scli8	245	13	binding	binding	NN
cord-312001-8p7scli8	245	14	and	and	CC
cord-312001-8p7scli8	245	15	cGAMP	cGAMP	NNP
cord-312001-8p7scli8	245	16	synthesis	synthesis	NN
cord-312001-8p7scli8	245	17	in	in	IN
cord-312001-8p7scli8	245	18	response	response	NN
cord-312001-8p7scli8	245	19	to	to	IN
cord-312001-8p7scli8	245	20	DNA	DNA	NNP
cord-312001-8p7scli8	245	21	in	in	IN
cord-312001-8p7scli8	245	22	the	the	DT
cord-312001-8p7scli8	245	23	cytosol	cytosol	NN
cord-312001-8p7scli8	245	24	,	,	,
cord-312001-8p7scli8	245	25	seems	seem	VBZ
cord-312001-8p7scli8	245	26	to	to	TO
cord-312001-8p7scli8	245	27	be	be	VB
cord-312001-8p7scli8	245	28	a	a	DT
cord-312001-8p7scli8	245	29	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	245	30	innovation	innovation	NN
cord-312001-8p7scli8	245	31	[	[	-LRB-
cord-312001-8p7scli8	245	32	169	169	CD
cord-312001-8p7scli8	245	33	]	]	-RRB-
cord-312001-8p7scli8	245	34	[	[	-LRB-
cord-312001-8p7scli8	245	35	170	170	CD
cord-312001-8p7scli8	245	36	]	]	-RRB-
cord-312001-8p7scli8	245	37	[	[	-LRB-
cord-312001-8p7scli8	245	38	171	171	CD
cord-312001-8p7scli8	245	39	]	]	-RRB-
cord-312001-8p7scli8	245	40	.	.	.
cord-312001-8p7scli8	246	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	246	2	,	,	,
cord-312001-8p7scli8	246	3	primate	primate	JJ
cord-312001-8p7scli8	246	4	cGAS	cgas	NN
cord-312001-8p7scli8	246	5	seems	seem	VBZ
cord-312001-8p7scli8	246	6	to	to	TO
cord-312001-8p7scli8	246	7	have	have	VB
cord-312001-8p7scli8	246	8	undergone	undergo	VBN
cord-312001-8p7scli8	246	9	rapid	rapid	JJ
cord-312001-8p7scli8	246	10	evolution	evolution	NN
cord-312001-8p7scli8	246	11	in	in	IN
cord-312001-8p7scli8	246	12	this	this	DT
cord-312001-8p7scli8	246	13	lineage	lineage	NN
cord-312001-8p7scli8	246	14	,	,	,
cord-312001-8p7scli8	246	15	as	as	IN
cord-312001-8p7scli8	246	16	observed	observe	VBN
cord-312001-8p7scli8	246	17	by	by	IN
cord-312001-8p7scli8	246	18	the	the	DT
cord-312001-8p7scli8	246	19	positive	positive	JJ
cord-312001-8p7scli8	246	20	selection	selection	NN
cord-312001-8p7scli8	246	21	at	at	IN
cord-312001-8p7scli8	246	22	its	-PRON-	PRP$
cord-312001-8p7scli8	246	23	nucleic	nucleic	JJ
cord-312001-8p7scli8	246	24	acid	acid	NN
cord-312001-8p7scli8	246	25	binding	binding	NN
cord-312001-8p7scli8	246	26	interfaces	interface	NNS
cord-312001-8p7scli8	246	27	[	[	-LRB-
cord-312001-8p7scli8	246	28	172	172	CD
cord-312001-8p7scli8	246	29	]	]	-RRB-
cord-312001-8p7scli8	246	30	.	.	.
cord-312001-8p7scli8	247	1	These	these	DT
cord-312001-8p7scli8	247	2	studies	study	NNS
cord-312001-8p7scli8	247	3	argue	argue	VBP
cord-312001-8p7scli8	247	4	that	that	IN
cord-312001-8p7scli8	247	5	although	although	IN
cord-312001-8p7scli8	247	6	the	the	DT
cord-312001-8p7scli8	247	7	cGAS	cgas	JJ
cord-312001-8p7scli8	247	8	enzyme	enzyme	NN
cord-312001-8p7scli8	247	9	existed	exist	VBD
cord-312001-8p7scli8	247	10	early	early	RB
cord-312001-8p7scli8	247	11	in	in	IN
cord-312001-8p7scli8	247	12	metazoans	metazoans	NNP
cord-312001-8p7scli8	247	13	,	,	,
cord-312001-8p7scli8	247	14	its	-PRON-	PRP$
cord-312001-8p7scli8	247	15	function	function	NN
cord-312001-8p7scli8	247	16	has	have	VBZ
cord-312001-8p7scli8	247	17	been	be	VBN
cord-312001-8p7scli8	247	18	repurposed	repurpose	VBN
cord-312001-8p7scli8	247	19	for	for	IN
cord-312001-8p7scli8	247	20	DNA	dna	NN
cord-312001-8p7scli8	247	21	sensing	sensing	NN
cord-312001-8p7scli8	247	22	only	only	RB
cord-312001-8p7scli8	247	23	recently	recently	RB
cord-312001-8p7scli8	247	24	in	in	IN
cord-312001-8p7scli8	247	25	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	247	26	.	.	.
cord-312001-8p7scli8	248	1	Clearly	clearly	RB
cord-312001-8p7scli8	248	2	,	,	,
cord-312001-8p7scli8	248	3	cGAS	cgas	NN
cord-312001-8p7scli8	248	4	and	and	CC
cord-312001-8p7scli8	248	5	STING	sting	NN
cord-312001-8p7scli8	248	6	seem	seem	VB
cord-312001-8p7scli8	248	7	to	to	TO
cord-312001-8p7scli8	248	8	have	have	VB
cord-312001-8p7scli8	248	9	acquired	acquire	VBN
cord-312001-8p7scli8	248	10	novel	novel	NN
cord-312001-8p7scli8	248	11	features	feature	NNS
cord-312001-8p7scli8	248	12	throughout	throughout	IN
cord-312001-8p7scli8	248	13	evolution	evolution	NN
cord-312001-8p7scli8	248	14	.	.	.
cord-312001-8p7scli8	249	1	Specifically	specifically	RB
cord-312001-8p7scli8	249	2	in	in	IN
cord-312001-8p7scli8	249	3	vertebrates	vertebrate	NNS
cord-312001-8p7scli8	249	4	cGAS	cgas	JJ
cord-312001-8p7scli8	249	5	evolved	evolve	VBD
cord-312001-8p7scli8	249	6	the	the	DT
cord-312001-8p7scli8	249	7	zinc	zinc	NN
cord-312001-8p7scli8	249	8	ribbon	ribbon	NN
cord-312001-8p7scli8	249	9	motif	motif	NN
cord-312001-8p7scli8	249	10	to	to	TO
cord-312001-8p7scli8	249	11	detect	detect	VB
cord-312001-8p7scli8	249	12	DNA	dna	NN
cord-312001-8p7scli8	249	13	and	and	CC
cord-312001-8p7scli8	249	14	STING	sting	NN
cord-312001-8p7scli8	250	1	evolved	evolve	VBD
cord-312001-8p7scli8	250	2	the	the	DT
cord-312001-8p7scli8	250	3	CTT	CTT	NNP
cord-312001-8p7scli8	250	4	domain	domain	NN
cord-312001-8p7scli8	250	5	that	that	WDT
cord-312001-8p7scli8	250	6	expanded	expand	VBD
cord-312001-8p7scli8	250	7	its	-PRON-	PRP$
cord-312001-8p7scli8	250	8	signaling	signal	VBG
cord-312001-8p7scli8	250	9	potential	potential	NN
cord-312001-8p7scli8	250	10	.	.	.
cord-312001-8p7scli8	251	1	As	as	IN
cord-312001-8p7scli8	251	2	obligate	obligate	VB
cord-312001-8p7scli8	251	3	intracellular	intracellular	JJ
cord-312001-8p7scli8	251	4	parasites	parasite	NNS
cord-312001-8p7scli8	251	5	,	,	,
cord-312001-8p7scli8	251	6	viruses	virus	NNS
cord-312001-8p7scli8	251	7	have	have	VBP
cord-312001-8p7scli8	251	8	evolved	evolve	VBN
cord-312001-8p7scli8	251	9	an	an	DT
cord-312001-8p7scli8	251	10	array	array	NN
cord-312001-8p7scli8	251	11	of	of	IN
cord-312001-8p7scli8	251	12	evasion	evasion	NN
cord-312001-8p7scli8	251	13	mechanisms	mechanism	NNS
cord-312001-8p7scli8	251	14	to	to	TO
cord-312001-8p7scli8	251	15	escape	escape	VB
cord-312001-8p7scli8	251	16	their	-PRON-	PRP$
cord-312001-8p7scli8	251	17	elimination	elimination	NN
cord-312001-8p7scli8	251	18	by	by	IN
cord-312001-8p7scli8	251	19	the	the	DT
cord-312001-8p7scli8	251	20	host	host	NN
cord-312001-8p7scli8	251	21	's	's	POS
cord-312001-8p7scli8	251	22	immune	immune	JJ
cord-312001-8p7scli8	251	23	system	system	NN
cord-312001-8p7scli8	251	24	.	.	.
cord-312001-8p7scli8	252	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	252	2	,	,	,
cord-312001-8p7scli8	252	3	viral	viral	JJ
cord-312001-8p7scli8	252	4	antagonism	antagonism	NN
cord-312001-8p7scli8	252	5	is	be	VBZ
cord-312001-8p7scli8	252	6	a	a	DT
cord-312001-8p7scli8	252	7	general	general	JJ
cord-312001-8p7scli8	252	8	strategy	strategy	NN
cord-312001-8p7scli8	252	9	and	and	CC
cord-312001-8p7scli8	252	10	is	be	VBZ
cord-312001-8p7scli8	252	11	not	not	RB
cord-312001-8p7scli8	252	12	a	a	DT
cord-312001-8p7scli8	252	13	peculiarity	peculiarity	NN
cord-312001-8p7scli8	252	14	of	of	IN
cord-312001-8p7scli8	252	15	animal	animal	NN
cord-312001-8p7scli8	252	16	viruses	virus	NNS
cord-312001-8p7scli8	252	17	.	.	.
cord-312001-8p7scli8	253	1	Many	many	JJ
cord-312001-8p7scli8	253	2	bacteriophages	bacteriophage	NNS
cord-312001-8p7scli8	253	3	,	,	,
cord-312001-8p7scli8	253	4	for	for	IN
cord-312001-8p7scli8	253	5	instance	instance	NN
cord-312001-8p7scli8	253	6	,	,	,
cord-312001-8p7scli8	253	7	encode	encode	VB
cord-312001-8p7scli8	253	8	CRISPR	CRISPR	NNP
cord-312001-8p7scli8	253	9	-	-	HYPH
cord-312001-8p7scli8	253	10	Cas	Cas	NNP
cord-312001-8p7scli8	253	11	inhibitors	inhibitor	NNS
cord-312001-8p7scli8	253	12	,	,	,
cord-312001-8p7scli8	253	13	termed	term	VBD
cord-312001-8p7scli8	253	14	anti	anti	JJ
cord-312001-8p7scli8	253	15	-	-	JJ
cord-312001-8p7scli8	253	16	CRISPRs	CRISPRs	NNPS
cord-312001-8p7scli8	253	17	,	,	,
cord-312001-8p7scli8	253	18	to	to	TO
cord-312001-8p7scli8	253	19	counter	counter	VB
cord-312001-8p7scli8	253	20	prokaryotic	prokaryotic	JJ
cord-312001-8p7scli8	253	21	antiviral	antiviral	JJ
cord-312001-8p7scli8	253	22	systems	system	NNS
cord-312001-8p7scli8	253	23	[	[	-LRB-
cord-312001-8p7scli8	253	24	173	173	CD
cord-312001-8p7scli8	253	25	]	]	-RRB-
cord-312001-8p7scli8	253	26	.	.	.
cord-312001-8p7scli8	254	1	Plant	plant	NN
cord-312001-8p7scli8	254	2	viruses	virus	NNS
cord-312001-8p7scli8	254	3	also	also	RB
cord-312001-8p7scli8	254	4	encode	encode	VBP
cord-312001-8p7scli8	254	5	viral	viral	JJ
cord-312001-8p7scli8	254	6	suppressors	suppressor	NNS
cord-312001-8p7scli8	254	7	of	of	IN
cord-312001-8p7scli8	254	8	RNAi	RNAi	NNP
cord-312001-8p7scli8	254	9	(	(	-LRB-
cord-312001-8p7scli8	254	10	VSRs	VSRs	NNP
cord-312001-8p7scli8	254	11	)	)	-RRB-
cord-312001-8p7scli8	254	12	the	the	DT
cord-312001-8p7scli8	254	13	main	main	JJ
cord-312001-8p7scli8	254	14	antiviral	antiviral	JJ
cord-312001-8p7scli8	254	15	system	system	NN
cord-312001-8p7scli8	254	16	in	in	IN
cord-312001-8p7scli8	254	17	plant	plant	NN
cord-312001-8p7scli8	254	18	cells	cell	NNS
cord-312001-8p7scli8	254	19	[	[	-LRB-
cord-312001-8p7scli8	254	20	20	20	CD
cord-312001-8p7scli8	254	21	]	]	-RRB-
cord-312001-8p7scli8	254	22	.	.	.
cord-312001-8p7scli8	255	1	Likewise	likewise	RB
cord-312001-8p7scli8	255	2	,	,	,
cord-312001-8p7scli8	255	3	several	several	JJ
cord-312001-8p7scli8	255	4	evasion	evasion	NN
cord-312001-8p7scli8	255	5	strategies	strategy	NNS
cord-312001-8p7scli8	255	6	and	and	CC
cord-312001-8p7scli8	255	7	immune	immune	JJ
cord-312001-8p7scli8	255	8	antagonisms	antagonism	NNS
cord-312001-8p7scli8	255	9	by	by	IN
cord-312001-8p7scli8	255	10	animal	animal	NN
cord-312001-8p7scli8	255	11	viruses	virus	NNS
cord-312001-8p7scli8	255	12	have	have	VBP
cord-312001-8p7scli8	255	13	been	be	VBN
cord-312001-8p7scli8	255	14	described	describe	VBN
cord-312001-8p7scli8	255	15	[	[	-LRB-
cord-312001-8p7scli8	255	16	174	174	CD
cord-312001-8p7scli8	255	17	]	]	-RRB-
cord-312001-8p7scli8	255	18	[	[	-LRB-
cord-312001-8p7scli8	255	19	175	175	CD
cord-312001-8p7scli8	255	20	]	]	-RRB-
cord-312001-8p7scli8	255	21	[	[	-LRB-
cord-312001-8p7scli8	255	22	176	176	CD
cord-312001-8p7scli8	255	23	]	]	-RRB-
cord-312001-8p7scli8	255	24	[	[	-LRB-
cord-312001-8p7scli8	255	25	177	177	CD
cord-312001-8p7scli8	255	26	]	]	-RRB-
cord-312001-8p7scli8	255	27	[	[	-LRB-
cord-312001-8p7scli8	255	28	178	178	CD
cord-312001-8p7scli8	255	29	]	]	-RRB-
cord-312001-8p7scli8	255	30	.	.	.
cord-312001-8p7scli8	256	1	These	these	DT
cord-312001-8p7scli8	256	2	include	include	VBP
cord-312001-8p7scli8	256	3	hiding	hide	VBG
cord-312001-8p7scli8	256	4	the	the	DT
cord-312001-8p7scli8	256	5	viral	viral	JJ
cord-312001-8p7scli8	256	6	genome	genome	NN
cord-312001-8p7scli8	256	7	from	from	IN
cord-312001-8p7scli8	256	8	immune	immune	JJ
cord-312001-8p7scli8	256	9	detection	detection	NN
cord-312001-8p7scli8	256	10	,	,	,
cord-312001-8p7scli8	256	11	shutting	shut	VBG
cord-312001-8p7scli8	256	12	off	off	RP
cord-312001-8p7scli8	256	13	host	host	NN
cord-312001-8p7scli8	256	14	translation	translation	NN
cord-312001-8p7scli8	256	15	or	or	CC
cord-312001-8p7scli8	256	16	transcription	transcription	NN
cord-312001-8p7scli8	256	17	machineries	machinery	NNS
cord-312001-8p7scli8	256	18	,	,	,
cord-312001-8p7scli8	256	19	inhibiting	inhibit	VBG
cord-312001-8p7scli8	256	20	host	host	NN
cord-312001-8p7scli8	256	21	RNA	rna	NN
cord-312001-8p7scli8	256	22	processing	processing	NN
cord-312001-8p7scli8	256	23	and	and	CC
cord-312001-8p7scli8	256	24	trafficking	trafficking	NN
cord-312001-8p7scli8	256	25	and	and	CC
cord-312001-8p7scli8	256	26	interfering	interfere	VBG
cord-312001-8p7scli8	256	27	directly	directly	RB
cord-312001-8p7scli8	256	28	with	with	IN
cord-312001-8p7scli8	256	29	either	either	CC
cord-312001-8p7scli8	256	30	proteins	protein	NNS
cord-312001-8p7scli8	256	31	that	that	WDT
cord-312001-8p7scli8	256	32	sense	sense	VBP
cord-312001-8p7scli8	256	33	viral	viral	JJ
cord-312001-8p7scli8	256	34	presence	presence	NN
cord-312001-8p7scli8	256	35	,	,	,
cord-312001-8p7scli8	256	36	or	or	CC
cord-312001-8p7scli8	256	37	factors	factor	NNS
cord-312001-8p7scli8	256	38	that	that	WDT
cord-312001-8p7scli8	256	39	signal	signal	VBP
cord-312001-8p7scli8	256	40	the	the	DT
cord-312001-8p7scli8	256	41	information	information	NN
cord-312001-8p7scli8	256	42	to	to	IN
cord-312001-8p7scli8	256	43	the	the	DT
cord-312001-8p7scli8	256	44	nucleus	nucleus	NN
cord-312001-8p7scli8	256	45	.	.	.
cord-312001-8p7scli8	257	1	Since	since	IN
cord-312001-8p7scli8	257	2	interfering	interfere	VBG
cord-312001-8p7scli8	257	3	with	with	IN
cord-312001-8p7scli8	257	4	the	the	DT
cord-312001-8p7scli8	257	5	innate	innate	JJ
cord-312001-8p7scli8	257	6	immune	immune	JJ
cord-312001-8p7scli8	257	7	system	system	NN
cord-312001-8p7scli8	257	8	is	be	VBZ
cord-312001-8p7scli8	257	9	less	less	RBR
cord-312001-8p7scli8	257	10	damaging	damaging	JJ
cord-312001-8p7scli8	257	11	for	for	IN
cord-312001-8p7scli8	257	12	the	the	DT
cord-312001-8p7scli8	257	13	host	host	NN
cord-312001-8p7scli8	257	14	than	than	IN
cord-312001-8p7scli8	257	15	targeting	target	VBG
cord-312001-8p7scli8	257	16	vital	vital	JJ
cord-312001-8p7scli8	257	17	cellular	cellular	JJ
cord-312001-8p7scli8	257	18	machineries	machinery	NNS
cord-312001-8p7scli8	257	19	(	(	-LRB-
cord-312001-8p7scli8	257	20	e.g.	e.g.	RB
cord-312001-8p7scli8	257	21	,	,	,
cord-312001-8p7scli8	257	22	translation	translation	NN
cord-312001-8p7scli8	257	23	)	)	-RRB-
cord-312001-8p7scli8	257	24	,	,	,
cord-312001-8p7scli8	257	25	many	many	JJ
cord-312001-8p7scli8	257	26	studied	study	VBN
cord-312001-8p7scli8	257	27	viruses	virus	NNS
cord-312001-8p7scli8	257	28	seem	seem	VBP
cord-312001-8p7scli8	257	29	to	to	TO
cord-312001-8p7scli8	257	30	have	have	VB
cord-312001-8p7scli8	257	31	opted	opt	VBN
cord-312001-8p7scli8	257	32	for	for	IN
cord-312001-8p7scli8	257	33	this	this	DT
cord-312001-8p7scli8	257	34	strategy	strategy	NN
cord-312001-8p7scli8	257	35	.	.	.
cord-312001-8p7scli8	258	1	Several	several	JJ
cord-312001-8p7scli8	258	2	studies	study	NNS
cord-312001-8p7scli8	258	3	describe	describe	VBP
cord-312001-8p7scli8	258	4	viral	viral	JJ
cord-312001-8p7scli8	258	5	evasion	evasion	NN
cord-312001-8p7scli8	258	6	mechanisms	mechanism	NNS
cord-312001-8p7scli8	258	7	at	at	IN
cord-312001-8p7scli8	258	8	both	both	CC
cord-312001-8p7scli8	258	9	the	the	DT
cord-312001-8p7scli8	258	10	recognition	recognition	NN
cord-312001-8p7scli8	258	11	and	and	CC
cord-312001-8p7scli8	258	12	sensing	sensing	NN
cord-312001-8p7scli8	258	13	step	step	NN
cord-312001-8p7scli8	258	14	(	(	-LRB-
cord-312001-8p7scli8	258	15	TLRs	TLRs	NNP
cord-312001-8p7scli8	258	16	,	,	,
cord-312001-8p7scli8	258	17	RLRs	rlr	NNS
cord-312001-8p7scli8	258	18	and	and	CC
cord-312001-8p7scli8	258	19	cGAS	cgas	NN
cord-312001-8p7scli8	258	20	-	-	HYPH
cord-312001-8p7scli8	258	21	STING	sting	NN
cord-312001-8p7scli8	258	22	)	)	-RRB-
cord-312001-8p7scli8	258	23	or	or	CC
cord-312001-8p7scli8	258	24	at	at	IN
cord-312001-8p7scli8	258	25	the	the	DT
cord-312001-8p7scli8	258	26	downstream	downstream	JJ
cord-312001-8p7scli8	258	27	signaling	signal	VBG
cord-312001-8p7scli8	258	28	steps	step	NNS
cord-312001-8p7scli8	258	29	through	through	IN
cord-312001-8p7scli8	258	30	the	the	DT
cord-312001-8p7scli8	258	31	targeting	targeting	NN
cord-312001-8p7scli8	258	32	of	of	IN
cord-312001-8p7scli8	258	33	proteins	protein	NNS
cord-312001-8p7scli8	258	34	such	such	JJ
cord-312001-8p7scli8	258	35	as	as	IN
cord-312001-8p7scli8	258	36	MAVS	MAVS	NNP
cord-312001-8p7scli8	258	37	,	,	,
cord-312001-8p7scli8	258	38	TBK1	TBK1	NNP
cord-312001-8p7scli8	258	39	,	,	,
cord-312001-8p7scli8	258	40	IRF3	IRF3	NNP
cord-312001-8p7scli8	258	41	,	,	,
cord-312001-8p7scli8	258	42	IRF7	IRF7	NNP
cord-312001-8p7scli8	258	43	and	and	CC
cord-312001-8p7scli8	258	44	NF	nf	NN
cord-312001-8p7scli8	258	45	-	-	HYPH
cord-312001-8p7scli8	258	46	κB.	κb.	JJ
cord-312001-8p7scli8	258	47	Evasion	evasion	NN
cord-312001-8p7scli8	258	48	strategies	strategy	NNS
cord-312001-8p7scli8	258	49	and	and	CC
cord-312001-8p7scli8	258	50	immune	immune	JJ
cord-312001-8p7scli8	258	51	antagonisms	antagonism	NNS
cord-312001-8p7scli8	258	52	by	by	IN
cord-312001-8p7scli8	258	53	animal	animal	NN
cord-312001-8p7scli8	258	54	viruses	virus	NNS
cord-312001-8p7scli8	258	55	are	be	VBP
cord-312001-8p7scli8	258	56	a	a	DT
cord-312001-8p7scli8	258	57	very	very	RB
cord-312001-8p7scli8	258	58	active	active	JJ
cord-312001-8p7scli8	258	59	area	area	NN
cord-312001-8p7scli8	258	60	of	of	IN
cord-312001-8p7scli8	258	61	research	research	NN
cord-312001-8p7scli8	258	62	,	,	,
cord-312001-8p7scli8	258	63	that	that	WDT
cord-312001-8p7scli8	258	64	have	have	VBP
cord-312001-8p7scli8	258	65	yielded	yield	VBN
cord-312001-8p7scli8	258	66	a	a	DT
cord-312001-8p7scli8	258	67	rich	rich	JJ
cord-312001-8p7scli8	258	68	literature	literature	NN
cord-312001-8p7scli8	258	69	in	in	IN
cord-312001-8p7scli8	258	70	the	the	DT
cord-312001-8p7scli8	258	71	past	past	JJ
cord-312001-8p7scli8	258	72	few	few	JJ
cord-312001-8p7scli8	258	73	years	year	NNS
cord-312001-8p7scli8	258	74	.	.	.
cord-312001-8p7scli8	259	1	We	-PRON-	PRP
cord-312001-8p7scli8	259	2	will	will	MD
cord-312001-8p7scli8	259	3	here	here	RB
cord-312001-8p7scli8	259	4	just	just	RB
cord-312001-8p7scli8	259	5	give	give	VB
cord-312001-8p7scli8	259	6	some	some	DT
cord-312001-8p7scli8	259	7	select	select	JJ
cord-312001-8p7scli8	259	8	examples	example	NNS
cord-312001-8p7scli8	259	9	of	of	IN
cord-312001-8p7scli8	259	10	viral	viral	JJ
cord-312001-8p7scli8	259	11	strategies	strategy	NNS
cord-312001-8p7scli8	259	12	that	that	WDT
cord-312001-8p7scli8	259	13	curb	curb	VBP
cord-312001-8p7scli8	259	14	sensing	sensing	NN
cord-312001-8p7scli8	259	15	and	and	CC
cord-312001-8p7scli8	259	16	signaling	signal	VBG
cord-312001-8p7scli8	259	17	by	by	IN
cord-312001-8p7scli8	259	18	TLRs	tlr	NNS
cord-312001-8p7scli8	259	19	,	,	,
cord-312001-8p7scli8	259	20	RLRs	rlr	NNS
cord-312001-8p7scli8	259	21	and	and	CC
cord-312001-8p7scli8	259	22	cGAS	cgas	NN
cord-312001-8p7scli8	259	23	-	-	HYPH
cord-312001-8p7scli8	259	24	STING	sting	NN
cord-312001-8p7scli8	259	25	in	in	IN
cord-312001-8p7scli8	259	26	animals	animal	NNS
cord-312001-8p7scli8	259	27	,	,	,
cord-312001-8p7scli8	259	28	with	with	IN
cord-312001-8p7scli8	259	29	an	an	DT
cord-312001-8p7scli8	259	30	obvious	obvious	JJ
cord-312001-8p7scli8	259	31	bias	bias	NN
cord-312001-8p7scli8	259	32	towards	towards	IN
cord-312001-8p7scli8	259	33	viruses	virus	NNS
cord-312001-8p7scli8	259	34	infecting	infect	VBG
cord-312001-8p7scli8	259	35	humans	human	NNS
cord-312001-8p7scli8	259	36	.	.	.
cord-312001-8p7scli8	260	1	For	for	IN
cord-312001-8p7scli8	260	2	a	a	DT
cord-312001-8p7scli8	260	3	more	more	RBR
cord-312001-8p7scli8	260	4	complete	complete	JJ
cord-312001-8p7scli8	260	5	picture	picture	NN
cord-312001-8p7scli8	260	6	on	on	IN
cord-312001-8p7scli8	260	7	the	the	DT
cord-312001-8p7scli8	260	8	subject	subject	NN
cord-312001-8p7scli8	260	9	,	,	,
cord-312001-8p7scli8	260	10	readers	reader	NNS
cord-312001-8p7scli8	260	11	can	can	MD
cord-312001-8p7scli8	260	12	refer	refer	VB
cord-312001-8p7scli8	260	13	to	to	IN
cord-312001-8p7scli8	260	14	excellent	excellent	JJ
cord-312001-8p7scli8	260	15	reviews	review	NNS
cord-312001-8p7scli8	260	16	,	,	,
cord-312001-8p7scli8	260	17	published	publish	VBN
cord-312001-8p7scli8	260	18	recently	recently	RB
cord-312001-8p7scli8	260	19	,	,	,
cord-312001-8p7scli8	260	20	describing	describe	VBG
cord-312001-8p7scli8	260	21	those	those	DT
cord-312001-8p7scli8	260	22	strategies	strategy	NNS
cord-312001-8p7scli8	260	23	[	[	-LRB-
cord-312001-8p7scli8	260	24	174	174	CD
cord-312001-8p7scli8	260	25	]	]	-RRB-
cord-312001-8p7scli8	260	26	[	[	-LRB-
cord-312001-8p7scli8	260	27	175	175	CD
cord-312001-8p7scli8	260	28	]	]	-RRB-
cord-312001-8p7scli8	260	29	[	[	-LRB-
cord-312001-8p7scli8	260	30	176	176	CD
cord-312001-8p7scli8	260	31	]	]	-RRB-
cord-312001-8p7scli8	260	32	[	[	-LRB-
cord-312001-8p7scli8	260	33	177	177	CD
cord-312001-8p7scli8	260	34	]	]	-RRB-
cord-312001-8p7scli8	260	35	[	[	-LRB-
cord-312001-8p7scli8	260	36	178	178	CD
cord-312001-8p7scli8	260	37	]	]	-RRB-
cord-312001-8p7scli8	260	38	.	.	.
cord-312001-8p7scli8	261	1	TLR	TLR	NNP
cord-312001-8p7scli8	261	2	signaling	signaling	NN
cord-312001-8p7scli8	261	3	has	have	VBZ
cord-312001-8p7scli8	261	4	been	be	VBN
cord-312001-8p7scli8	261	5	shown	show	VBN
cord-312001-8p7scli8	261	6	to	to	TO
cord-312001-8p7scli8	261	7	be	be	VB
cord-312001-8p7scli8	261	8	inhibited	inhibit	VBN
cord-312001-8p7scli8	261	9	by	by	IN
cord-312001-8p7scli8	261	10	the	the	DT
cord-312001-8p7scli8	261	11	vaccinia	vaccinia	NN
cord-312001-8p7scli8	261	12	virus	virus	NN
cord-312001-8p7scli8	261	13	(	(	-LRB-
cord-312001-8p7scli8	261	14	VACV	VACV	NNP
cord-312001-8p7scli8	261	15	)	)	-RRB-
cord-312001-8p7scli8	261	16	protein	protein	NN
cord-312001-8p7scli8	261	17	A46R	A46R	NNS
cord-312001-8p7scli8	261	18	,	,	,
cord-312001-8p7scli8	261	19	that	that	WDT
cord-312001-8p7scli8	261	20	targets	target	VBZ
cord-312001-8p7scli8	261	21	specific	specific	JJ
cord-312001-8p7scli8	261	22	TIR	tir	NN
cord-312001-8p7scli8	261	23	-	-	HYPH
cord-312001-8p7scli8	261	24	domain	domain	NN
cord-312001-8p7scli8	261	25	-	-	HYPH
cord-312001-8p7scli8	261	26	containing	contain	VBG
cord-312001-8p7scli8	261	27	adaptor	adaptor	NN
cord-312001-8p7scli8	261	28	proteins	protein	NNS
cord-312001-8p7scli8	261	29	.	.	.
cord-312001-8p7scli8	262	1	A46R	A46R	NNPS
cord-312001-8p7scli8	262	2	itself	-PRON-	PRP
cord-312001-8p7scli8	262	3	contains	contain	VBZ
cord-312001-8p7scli8	262	4	a	a	DT
cord-312001-8p7scli8	262	5	TIR	TIR	NNP
cord-312001-8p7scli8	262	6	domain	domain	NN
cord-312001-8p7scli8	262	7	which	which	WDT
cord-312001-8p7scli8	262	8	allows	allow	VBZ
cord-312001-8p7scli8	262	9	it	-PRON-	PRP
cord-312001-8p7scli8	262	10	to	to	TO
cord-312001-8p7scli8	262	11	competitively	competitively	RB
cord-312001-8p7scli8	262	12	interact	interact	VB
cord-312001-8p7scli8	262	13	with	with	IN
cord-312001-8p7scli8	262	14	TIR	tir	NN
cord-312001-8p7scli8	262	15	-	-	HYPH
cord-312001-8p7scli8	262	16	domain	domain	NN
cord-312001-8p7scli8	262	17	-	-	HYPH
cord-312001-8p7scli8	262	18	containing	contain	VBG
cord-312001-8p7scli8	262	19	complexes	complex	NNS
cord-312001-8p7scli8	262	20	such	such	JJ
cord-312001-8p7scli8	262	21	as	as	IN
cord-312001-8p7scli8	262	22	Myd88	Myd88	NNP
cord-312001-8p7scli8	262	23	,	,	,
cord-312001-8p7scli8	262	24	TRIF	TRIF	NNP
cord-312001-8p7scli8	262	25	or	or	CC
cord-312001-8p7scli8	262	26	TRAM	TRAM	NNP
cord-312001-8p7scli8	262	27	,	,	,
cord-312001-8p7scli8	262	28	thereby	thereby	RB
cord-312001-8p7scli8	262	29	inhibiting	inhibit	VBG
cord-312001-8p7scli8	262	30	the	the	DT
cord-312001-8p7scli8	262	31	activation	activation	NN
cord-312001-8p7scli8	262	32	of	of	IN
cord-312001-8p7scli8	262	33	both	both	CC
cord-312001-8p7scli8	262	34	NFkB	NFkB	NNP
cord-312001-8p7scli8	262	35	and	and	CC
cord-312001-8p7scli8	262	36	IRFs	IRFs	NNP
cord-312001-8p7scli8	262	37	[	[	-LRB-
cord-312001-8p7scli8	262	38	179	179	CD
cord-312001-8p7scli8	262	39	,	,	,
cord-312001-8p7scli8	262	40	180	180	CD
cord-312001-8p7scli8	262	41	]	]	-RRB-
cord-312001-8p7scli8	262	42	.	.	.
cord-312001-8p7scli8	263	1	Human	human	JJ
cord-312001-8p7scli8	263	2	T	t	NN
cord-312001-8p7scli8	263	3	-	-	HYPH
cord-312001-8p7scli8	263	4	cell	cell	NN
cord-312001-8p7scli8	263	5	leukemia	leukemia	NN
cord-312001-8p7scli8	263	6	virus	virus	NN
cord-312001-8p7scli8	263	7	type-1	type-1	NN
cord-312001-8p7scli8	263	8	(	(	-LRB-
cord-312001-8p7scli8	263	9	HTLV-1	HTLV-1	NNP
cord-312001-8p7scli8	263	10	)	)	-RRB-
cord-312001-8p7scli8	263	11	is	be	VBZ
cord-312001-8p7scli8	263	12	also	also	RB
cord-312001-8p7scli8	263	13	able	able	JJ
cord-312001-8p7scli8	263	14	to	to	TO
cord-312001-8p7scli8	263	15	interfere	interfere	VB
cord-312001-8p7scli8	263	16	with	with	IN
cord-312001-8p7scli8	263	17	TLR4-dependent	tlr4-dependent	NN
cord-312001-8p7scli8	263	18	signaling	signaling	NN
cord-312001-8p7scli8	263	19	.	.	.
cord-312001-8p7scli8	264	1	The	the	DT
cord-312001-8p7scli8	264	2	HTLV-1	HTLV-1	NNP
cord-312001-8p7scli8	264	3	encoded	encode	VBD
cord-312001-8p7scli8	264	4	viral	viral	JJ
cord-312001-8p7scli8	264	5	protein	protein	NN
cord-312001-8p7scli8	264	6	p30	p30	NNP
cord-312001-8p7scli8	264	7	binds	bind	VBZ
cord-312001-8p7scli8	264	8	and	and	CC
cord-312001-8p7scli8	264	9	disables	disable	VBZ
cord-312001-8p7scli8	264	10	a	a	DT
cord-312001-8p7scli8	264	11	transcription	transcription	NN
cord-312001-8p7scli8	264	12	factor	factor	NN
cord-312001-8p7scli8	264	13	,	,	,
cord-312001-8p7scli8	264	14	PU.1	PU.1	NNP
cord-312001-8p7scli8	264	15	,	,	,
cord-312001-8p7scli8	264	16	required	require	VBN
cord-312001-8p7scli8	264	17	for	for	IN
cord-312001-8p7scli8	264	18	TLR4	TLR4	NNP
cord-312001-8p7scli8	264	19	surface	surface	NN
cord-312001-8p7scli8	264	20	expression	expression	NN
cord-312001-8p7scli8	264	21	[	[	-LRB-
cord-312001-8p7scli8	264	22	181	181	CD
cord-312001-8p7scli8	264	23	]	]	-RRB-
cord-312001-8p7scli8	264	24	.	.	.
cord-312001-8p7scli8	265	1	TRIF	TRIF	NNP
cord-312001-8p7scli8	265	2	,	,	,
cord-312001-8p7scli8	265	3	an	an	DT
cord-312001-8p7scli8	265	4	important	important	JJ
cord-312001-8p7scli8	265	5	player	player	NN
cord-312001-8p7scli8	265	6	in	in	IN
cord-312001-8p7scli8	265	7	the	the	DT
cord-312001-8p7scli8	265	8	TLR	TLR	NNP
cord-312001-8p7scli8	265	9	signaling	signal	VBG
cord-312001-8p7scli8	265	10	cascade	cascade	NN
cord-312001-8p7scli8	265	11	,	,	,
cord-312001-8p7scli8	265	12	is	be	VBZ
cord-312001-8p7scli8	265	13	a	a	DT
cord-312001-8p7scli8	265	14	target	target	NN
cord-312001-8p7scli8	265	15	of	of	IN
cord-312001-8p7scli8	265	16	choice	choice	NN
cord-312001-8p7scli8	265	17	of	of	IN
cord-312001-8p7scli8	265	18	many	many	JJ
cord-312001-8p7scli8	265	19	viruses	virus	NNS
cord-312001-8p7scli8	265	20	.	.	.
cord-312001-8p7scli8	266	1	The	the	DT
cord-312001-8p7scli8	266	2	NS3/4A	ns3/4a	JJ
cord-312001-8p7scli8	266	3	protease	protease	NN
cord-312001-8p7scli8	266	4	of	of	IN
cord-312001-8p7scli8	266	5	HCV	HCV	NNP
cord-312001-8p7scli8	266	6	and	and	CC
cord-312001-8p7scli8	266	7	the	the	DT
cord-312001-8p7scli8	266	8	3C	3c	NN
cord-312001-8p7scli8	266	9	proteases	protease	NNS
cord-312001-8p7scli8	266	10	of	of	IN
cord-312001-8p7scli8	266	11	several	several	JJ
cord-312001-8p7scli8	266	12	picornaviruses	picornavirus	NNS
cord-312001-8p7scli8	266	13	such	such	JJ
cord-312001-8p7scli8	266	14	as	as	IN
cord-312001-8p7scli8	266	15	coxsackievirus	coxsackievirus	NNP
cord-312001-8p7scli8	266	16	B	B	NNP
cord-312001-8p7scli8	266	17	,	,	,
cord-312001-8p7scli8	266	18	EV71	EV71	NNP
cord-312001-8p7scli8	266	19	and	and	CC
cord-312001-8p7scli8	266	20	hepatitis	hepatitis	NNP
cord-312001-8p7scli8	266	21	A	a	DT
cord-312001-8p7scli8	266	22	virus	virus	NN
cord-312001-8p7scli8	266	23	(	(	-LRB-
cord-312001-8p7scli8	266	24	HAV	HAV	NNP
cord-312001-8p7scli8	266	25	)	)	-RRB-
cord-312001-8p7scli8	266	26	,	,	,
cord-312001-8p7scli8	266	27	can	can	MD
cord-312001-8p7scli8	266	28	all	all	RB
cord-312001-8p7scli8	266	29	recognize	recognize	VB
cord-312001-8p7scli8	266	30	and	and	CC
cord-312001-8p7scli8	266	31	proteolytically	proteolytically	RB
cord-312001-8p7scli8	266	32	cleave	cleave	VB
cord-312001-8p7scli8	266	33	TRIF	TRIF	NNP
cord-312001-8p7scli8	266	34	,	,	,
cord-312001-8p7scli8	266	35	producing	produce	VBG
cord-312001-8p7scli8	266	36	TRIF	trif	NN
cord-312001-8p7scli8	266	37	fragments	fragment	NNS
cord-312001-8p7scli8	266	38	that	that	WDT
cord-312001-8p7scli8	266	39	are	be	VBP
cord-312001-8p7scli8	266	40	unable	unable	JJ
cord-312001-8p7scli8	266	41	to	to	TO
cord-312001-8p7scli8	266	42	signal	signal	VB
cord-312001-8p7scli8	266	43	[	[	-LRB-
cord-312001-8p7scli8	266	44	182	182	CD
cord-312001-8p7scli8	266	45	]	]	-RRB-
cord-312001-8p7scli8	267	1	[	[	-LRB-
cord-312001-8p7scli8	267	2	183	183	CD
cord-312001-8p7scli8	267	3	]	]	-RRB-
cord-312001-8p7scli8	267	4	[	[	-LRB-
cord-312001-8p7scli8	267	5	184	184	CD
cord-312001-8p7scli8	267	6	]	]	-RRB-
cord-312001-8p7scli8	267	7	[	[	-LRB-
cord-312001-8p7scli8	267	8	185	185	CD
cord-312001-8p7scli8	267	9	]	]	-RRB-
cord-312001-8p7scli8	267	10	[	[	-LRB-
cord-312001-8p7scli8	267	11	186	186	CD
cord-312001-8p7scli8	267	12	]	]	-RRB-
cord-312001-8p7scli8	267	13	.	.	.
cord-312001-8p7scli8	268	1	When	when	WRB
cord-312001-8p7scli8	268	2	it	-PRON-	PRP
cord-312001-8p7scli8	268	3	comes	come	VBZ
cord-312001-8p7scli8	268	4	to	to	IN
cord-312001-8p7scli8	268	5	RLRs	rlr	NNS
cord-312001-8p7scli8	268	6	,	,	,
cord-312001-8p7scli8	268	7	one	one	CD
cord-312001-8p7scli8	268	8	basic	basic	JJ
cord-312001-8p7scli8	268	9	strategy	strategy	NN
cord-312001-8p7scli8	268	10	used	use	VBN
cord-312001-8p7scli8	268	11	by	by	IN
cord-312001-8p7scli8	268	12	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	268	13	viruses	virus	NNS
cord-312001-8p7scli8	268	14	to	to	TO
cord-312001-8p7scli8	268	15	escape	escape	VB
cord-312001-8p7scli8	268	16	surveillance	surveillance	NN
cord-312001-8p7scli8	268	17	is	be	VBZ
cord-312001-8p7scli8	268	18	to	to	TO
cord-312001-8p7scli8	268	19	simply	simply	RB
cord-312001-8p7scli8	268	20	prevent	prevent	VB
cord-312001-8p7scli8	268	21	these	these	DT
cord-312001-8p7scli8	268	22	receptors	receptor	NNS
cord-312001-8p7scli8	268	23	from	from	IN
cord-312001-8p7scli8	268	24	accessing	access	VBG
cord-312001-8p7scli8	268	25	viral	viral	JJ
cord-312001-8p7scli8	268	26	genomes	genome	NNS
cord-312001-8p7scli8	268	27	.	.	.
cord-312001-8p7scli8	269	1	DENV	DENV	NNP
cord-312001-8p7scli8	269	2	,	,	,
cord-312001-8p7scli8	269	3	for	for	IN
cord-312001-8p7scli8	269	4	example	example	NN
cord-312001-8p7scli8	269	5	,	,	,
cord-312001-8p7scli8	269	6	replicates	replicate	VBZ
cord-312001-8p7scli8	269	7	in	in	IN
cord-312001-8p7scli8	269	8	convoluted	convoluted	JJ
cord-312001-8p7scli8	269	9	membranes	membrane	NNS
cord-312001-8p7scli8	269	10	of	of	IN
cord-312001-8p7scli8	269	11	the	the	DT
cord-312001-8p7scli8	269	12	ER	ER	NNP
cord-312001-8p7scli8	269	13	concealing	conceal	VBG
cord-312001-8p7scli8	269	14	its	-PRON-	PRP$
cord-312001-8p7scli8	269	15	dsRNA	dsrna	NN
cord-312001-8p7scli8	269	16	intermediates	intermediate	NNS
cord-312001-8p7scli8	269	17	from	from	IN
cord-312001-8p7scli8	269	18	the	the	DT
cord-312001-8p7scli8	269	19	cytosol	cytosol	NN
cord-312001-8p7scli8	269	20	and	and	CC
cord-312001-8p7scli8	269	21	thereby	thereby	RB
cord-312001-8p7scli8	269	22	prevents	prevent	VBZ
cord-312001-8p7scli8	269	23	the	the	DT
cord-312001-8p7scli8	269	24	activation	activation	NN
cord-312001-8p7scli8	269	25	of	of	IN
cord-312001-8p7scli8	269	26	RLRs	rlr	NNS
cord-312001-8p7scli8	269	27	[	[	-LRB-
cord-312001-8p7scli8	269	28	187	187	CD
cord-312001-8p7scli8	269	29	]	]	-RRB-
cord-312001-8p7scli8	269	30	.	.	.
cord-312001-8p7scli8	270	1	Other	other	JJ
cord-312001-8p7scli8	270	2	viruses	virus	NNS
cord-312001-8p7scli8	270	3	like	like	IN
cord-312001-8p7scli8	270	4	Ebola	Ebola	NNP
cord-312001-8p7scli8	270	5	virus	virus	NN
cord-312001-8p7scli8	270	6	(	(	-LRB-
cord-312001-8p7scli8	270	7	EBOV	EBOV	NNP
cord-312001-8p7scli8	270	8	)	)	-RRB-
cord-312001-8p7scli8	270	9	and	and	CC
cord-312001-8p7scli8	271	1	Marburg	Marburg	NNP
cord-312001-8p7scli8	271	2	viruses	virus	NNS
cord-312001-8p7scli8	271	3	encode	encode	VBP
cord-312001-8p7scli8	271	4	viral	viral	JJ
cord-312001-8p7scli8	271	5	protein	protein	NN
cord-312001-8p7scli8	271	6	35	35	CD
cord-312001-8p7scli8	271	7	(	(	-LRB-
cord-312001-8p7scli8	271	8	VP35	VP35	NNP
cord-312001-8p7scli8	271	9	)	)	-RRB-
cord-312001-8p7scli8	271	10	that	that	WDT
cord-312001-8p7scli8	271	11	tightly	tightly	RB
cord-312001-8p7scli8	271	12	binds	bind	VBZ
cord-312001-8p7scli8	271	13	and	and	CC
cord-312001-8p7scli8	271	14	'	'	``
cord-312001-8p7scli8	271	15	shields	shield	NNS
cord-312001-8p7scli8	271	16	'	'	POS
cord-312001-8p7scli8	271	17	the	the	DT
cord-312001-8p7scli8	271	18	viral	viral	JJ
cord-312001-8p7scli8	271	19	genome	genome	NN
cord-312001-8p7scli8	271	20	from	from	IN
cord-312001-8p7scli8	271	21	detection	detection	NN
cord-312001-8p7scli8	271	22	by	by	IN
cord-312001-8p7scli8	271	23	RIG-	RIG-	NNP
cord-312001-8p7scli8	272	1	I	-PRON-	PRP
cord-312001-8p7scli8	272	2	[	[	-LRB-
cord-312001-8p7scli8	272	3	188	188	CD
cord-312001-8p7scli8	272	4	,	,	,
cord-312001-8p7scli8	272	5	189	189	CD
cord-312001-8p7scli8	272	6	]	]	-RRB-
cord-312001-8p7scli8	272	7	.	.	.
cord-312001-8p7scli8	273	1	Another	another	DT
cord-312001-8p7scli8	273	2	strategy	strategy	NN
cord-312001-8p7scli8	273	3	used	use	VBN
cord-312001-8p7scli8	273	4	by	by	IN
cord-312001-8p7scli8	273	5	viruses	virus	NNS
cord-312001-8p7scli8	273	6	to	to	TO
cord-312001-8p7scli8	273	7	'	'	``
cord-312001-8p7scli8	273	8	hide	hide	VB
cord-312001-8p7scli8	273	9	'	'	''
cord-312001-8p7scli8	273	10	from	from	IN
cord-312001-8p7scli8	273	11	RLRs	rlr	NNS
cord-312001-8p7scli8	273	12	consists	consist	VBZ
cord-312001-8p7scli8	273	13	of	of	IN
cord-312001-8p7scli8	273	14	modifying	modify	VBG
cord-312001-8p7scli8	273	15	the	the	DT
cord-312001-8p7scli8	273	16	very	very	RB
cord-312001-8p7scli8	273	17	molecular	molecular	JJ
cord-312001-8p7scli8	273	18	features	feature	VBZ
cord-312001-8p7scli8	273	19	these	these	DT
cord-312001-8p7scli8	273	20	receptors	receptor	NNS
cord-312001-8p7scli8	273	21	rely	rely	VBP
cord-312001-8p7scli8	273	22	on	on	IN
cord-312001-8p7scli8	273	23	to	to	TO
cord-312001-8p7scli8	273	24	recognize	recognize	VB
cord-312001-8p7scli8	273	25	viral	viral	JJ
cord-312001-8p7scli8	273	26	genomes	genome	NNS
cord-312001-8p7scli8	273	27	.	.	.
cord-312001-8p7scli8	274	1	For	for	IN
cord-312001-8p7scli8	274	2	example	example	NN
cord-312001-8p7scli8	274	3	,	,	,
cord-312001-8p7scli8	274	4	both	both	DT
cord-312001-8p7scli8	274	5	,	,	,
cord-312001-8p7scli8	274	6	Hantaan	Hantaan	NNP
cord-312001-8p7scli8	274	7	viruses	virus	NNS
cord-312001-8p7scli8	274	8	from	from	IN
cord-312001-8p7scli8	274	9	the	the	DT
cord-312001-8p7scli8	274	10	Bunyaviridae	Bunyaviridae	NNP
cord-312001-8p7scli8	274	11	family	family	NN
cord-312001-8p7scli8	274	12	and	and	CC
cord-312001-8p7scli8	274	13	Borna	Borna	NNP
cord-312001-8p7scli8	274	14	disease	disease	NN
cord-312001-8p7scli8	274	15	virus	virus	NN
cord-312001-8p7scli8	274	16	(	(	-LRB-
cord-312001-8p7scli8	274	17	BDV	BDV	NNP
cord-312001-8p7scli8	274	18	)	)	-RRB-
cord-312001-8p7scli8	274	19	from	from	IN
cord-312001-8p7scli8	274	20	the	the	DT
cord-312001-8p7scli8	274	21	Bornaviridae	Bornaviridae	NNP
cord-312001-8p7scli8	274	22	family	family	NN
cord-312001-8p7scli8	274	23	,	,	,
cord-312001-8p7scli8	274	24	encode	encode	VB
cord-312001-8p7scli8	274	25	phosphatases	phosphatase	NNS
cord-312001-8p7scli8	274	26	that	that	WDT
cord-312001-8p7scli8	274	27	process	process	VBP
cord-312001-8p7scli8	274	28	the	the	DT
cord-312001-8p7scli8	274	29	triphosphate	triphosphate	NN
cord-312001-8p7scli8	274	30	group	group	NN
cord-312001-8p7scli8	274	31	at	at	IN
cord-312001-8p7scli8	274	32	their	-PRON-	PRP$
cord-312001-8p7scli8	274	33	5	5	CD
cord-312001-8p7scli8	274	34	genome	genome	NN
cord-312001-8p7scli8	274	35	termini	terminus	NNS
cord-312001-8p7scli8	274	36	,	,	,
cord-312001-8p7scli8	274	37	to	to	IN
cord-312001-8p7scli8	274	38	a	a	DT
cord-312001-8p7scli8	274	39	5	5	CD
cord-312001-8p7scli8	274	40	-monophosphate	-monophosphate	SYM
cord-312001-8p7scli8	274	41	to	to	TO
cord-312001-8p7scli8	274	42	escape	escape	VB
cord-312001-8p7scli8	274	43	RIG	rig	NN
cord-312001-8p7scli8	274	44	-	-	:
cord-312001-8p7scli8	274	45	I	-PRON-	PRP
cord-312001-8p7scli8	274	46	surveillance	surveillance	NN
cord-312001-8p7scli8	274	47	[	[	-LRB-
cord-312001-8p7scli8	274	48	190	190	CD
cord-312001-8p7scli8	274	49	,	,	,
cord-312001-8p7scli8	274	50	191	191	CD
cord-312001-8p7scli8	274	51	]	]	-RRB-
cord-312001-8p7scli8	274	52	.	.	.
cord-312001-8p7scli8	275	1	Lassa	Lassa	NNP
cord-312001-8p7scli8	275	2	Virus	Virus	NNP
cord-312001-8p7scli8	275	3	(	(	-LRB-
cord-312001-8p7scli8	275	4	LASV	LASV	NNP
cord-312001-8p7scli8	275	5	)	)	-RRB-
cord-312001-8p7scli8	275	6	from	from	IN
cord-312001-8p7scli8	275	7	the	the	DT
cord-312001-8p7scli8	275	8	Arenaviridae	Arenaviridae	NNP
cord-312001-8p7scli8	275	9	family	family	NN
cord-312001-8p7scli8	275	10	evolved	evolve	VBD
cord-312001-8p7scli8	275	11	a	a	DT
cord-312001-8p7scli8	275	12	unique	unique	JJ
cord-312001-8p7scli8	275	13	strategy	strategy	NN
cord-312001-8p7scli8	275	14	in	in	IN
cord-312001-8p7scli8	275	15	which	which	WDT
cord-312001-8p7scli8	275	16	its	-PRON-	PRP$
cord-312001-8p7scli8	275	17	nucleoprotein	nucleoprotein	NNP
cord-312001-8p7scli8	275	18	(	(	-LRB-
cord-312001-8p7scli8	275	19	NP	NP	NNP
cord-312001-8p7scli8	275	20	)	)	-RRB-
cord-312001-8p7scli8	275	21	acquired	acquire	VBD
cord-312001-8p7scli8	275	22	a	a	DT
cord-312001-8p7scli8	275	23	3	3	CD
cord-312001-8p7scli8	275	24	-5	-5	NN
cord-312001-8p7scli8	275	25	exonuclease	exonuclease	NN
cord-312001-8p7scli8	275	26	activity	activity	NN
cord-312001-8p7scli8	275	27	,	,	,
cord-312001-8p7scli8	275	28	that	that	WDT
cord-312001-8p7scli8	275	29	enables	enable	VBZ
cord-312001-8p7scli8	275	30	it	-PRON-	PRP
cord-312001-8p7scli8	275	31	to	to	TO
cord-312001-8p7scli8	275	32	digest	digest	VB
cord-312001-8p7scli8	275	33	free	free	JJ
cord-312001-8p7scli8	275	34	dsRNA	dsrna	NN
cord-312001-8p7scli8	275	35	,	,	,
cord-312001-8p7scli8	275	36	preventing	prevent	VBG
cord-312001-8p7scli8	275	37	the	the	DT
cord-312001-8p7scli8	275	38	activation	activation	NN
cord-312001-8p7scli8	275	39	of	of	IN
cord-312001-8p7scli8	275	40	RIG	rig	NN
cord-312001-8p7scli8	275	41	-	-	:
cord-312001-8p7scli8	275	42	I	-PRON-	PRP
cord-312001-8p7scli8	275	43	[	[	-LRB-
cord-312001-8p7scli8	275	44	192	192	CD
cord-312001-8p7scli8	275	45	]	]	-RRB-
cord-312001-8p7scli8	275	46	.	.	.
cord-312001-8p7scli8	276	1	However	however	RB
cord-312001-8p7scli8	276	2	,	,	,
cord-312001-8p7scli8	276	3	the	the	DT
cord-312001-8p7scli8	276	4	most	most	RBS
cord-312001-8p7scli8	276	5	direct	direct	JJ
cord-312001-8p7scli8	276	6	way	way	NN
cord-312001-8p7scli8	276	7	of	of	IN
cord-312001-8p7scli8	276	8	interfering	interfere	VBG
cord-312001-8p7scli8	276	9	with	with	IN
cord-312001-8p7scli8	276	10	RLR	RLR	NNP
cord-312001-8p7scli8	276	11	function	function	NN
cord-312001-8p7scli8	276	12	and	and	CC
cord-312001-8p7scli8	276	13	their	-PRON-	PRP$
cord-312001-8p7scli8	276	14	signaling	signal	VBG
cord-312001-8p7scli8	276	15	partners	partner	NNS
cord-312001-8p7scli8	276	16	is	be	VBZ
cord-312001-8p7scli8	276	17	to	to	IN
cord-312001-8p7scli8	276	18	either	either	CC
cord-312001-8p7scli8	276	19	directly	directly	RB
cord-312001-8p7scli8	276	20	target	target	VB
cord-312001-8p7scli8	276	21	them	-PRON-	PRP
cord-312001-8p7scli8	276	22	for	for	IN
cord-312001-8p7scli8	276	23	cleavage	cleavage	NN
cord-312001-8p7scli8	276	24	and	and	CC
cord-312001-8p7scli8	276	25	degradation	degradation	NN
cord-312001-8p7scli8	276	26	or	or	CC
cord-312001-8p7scli8	276	27	to	to	TO
cord-312001-8p7scli8	276	28	manipulate	manipulate	VB
cord-312001-8p7scli8	276	29	their	-PRON-	PRP$
cord-312001-8p7scli8	276	30	phosphorylation	phosphorylation	NN
cord-312001-8p7scli8	276	31	and	and	CC
cord-312001-8p7scli8	276	32	ubiquitination	ubiquitination	NN
cord-312001-8p7scli8	276	33	statuses	status	NNS
cord-312001-8p7scli8	276	34	,	,	,
cord-312001-8p7scli8	276	35	which	which	WDT
cord-312001-8p7scli8	276	36	are	be	VBP
cord-312001-8p7scli8	276	37	crucial	crucial	JJ
cord-312001-8p7scli8	276	38	for	for	IN
cord-312001-8p7scli8	276	39	their	-PRON-	PRP$
cord-312001-8p7scli8	276	40	activation	activation	NN
cord-312001-8p7scli8	276	41	.	.	.
cord-312001-8p7scli8	277	1	Indeed	indeed	RB
cord-312001-8p7scli8	277	2	,	,	,
cord-312001-8p7scli8	277	3	many	many	JJ
cord-312001-8p7scli8	277	4	viruses	virus	NNS
cord-312001-8p7scli8	277	5	encode	encode	VBP
cord-312001-8p7scli8	277	6	proteases	protease	NNS
cord-312001-8p7scli8	277	7	that	that	WDT
cord-312001-8p7scli8	277	8	directly	directly	RB
cord-312001-8p7scli8	277	9	cleave	cleave	VBP
cord-312001-8p7scli8	277	10	RLRs	rlr	NNS
cord-312001-8p7scli8	277	11	.	.	.
cord-312001-8p7scli8	278	1	While	while	IN
cord-312001-8p7scli8	278	2	the	the	DT
cord-312001-8p7scli8	278	3	3Cpro	3cpro	CD
cord-312001-8p7scli8	278	4	proteases	protease	NNS
cord-312001-8p7scli8	278	5	of	of	IN
cord-312001-8p7scli8	278	6	both	both	DT
cord-312001-8p7scli8	278	7	poliovirus	poliovirus	NN
cord-312001-8p7scli8	278	8	and	and	CC
cord-312001-8p7scli8	278	9	EV71	EV71	NNP
cord-312001-8p7scli8	278	10	cleave	cleave	VB
cord-312001-8p7scli8	278	11	RIG	rig	NN
cord-312001-8p7scli8	278	12	-	-	:
cord-312001-8p7scli8	278	13	I	I	NNP
cord-312001-8p7scli8	278	14	,	,	,
cord-312001-8p7scli8	278	15	the	the	DT
cord-312001-8p7scli8	278	16	2Apro	2apro	CD
cord-312001-8p7scli8	278	17	of	of	IN
cord-312001-8p7scli8	278	18	EV71	EV71	NNP
cord-312001-8p7scli8	278	19	cleaves	cleave	VBZ
cord-312001-8p7scli8	278	20	MDA5	MDA5	NNP
cord-312001-8p7scli8	278	21	[	[	-LRB-
cord-312001-8p7scli8	278	22	193	193	CD
cord-312001-8p7scli8	278	23	,	,	,
cord-312001-8p7scli8	278	24	194	194	CD
cord-312001-8p7scli8	278	25	]	]	-RRB-
cord-312001-8p7scli8	278	26	.	.	.
cord-312001-8p7scli8	279	1	MAVS	MAVS	NNP
cord-312001-8p7scli8	279	2	,	,	,
cord-312001-8p7scli8	279	3	a	a	DT
cord-312001-8p7scli8	279	4	crucial	crucial	JJ
cord-312001-8p7scli8	279	5	hub	hub	NN
cord-312001-8p7scli8	279	6	for	for	IN
cord-312001-8p7scli8	279	7	both	both	CC
cord-312001-8p7scli8	279	8	RIG-	RIG-	NNP
cord-312001-8p7scli8	280	1	I	-PRON-	PRP
cord-312001-8p7scli8	280	2	and	and	CC
cord-312001-8p7scli8	280	3	MDA5-mediated	MDA5-mediated	NNP
cord-312001-8p7scli8	280	4	signaling	signaling	NN
cord-312001-8p7scli8	280	5	is	be	VBZ
cord-312001-8p7scli8	280	6	also	also	RB
cord-312001-8p7scli8	280	7	frequently	frequently	RB
cord-312001-8p7scli8	280	8	targeted	target	VBN
cord-312001-8p7scli8	280	9	and	and	CC
cord-312001-8p7scli8	280	10	cleaved	cleave	VBN
cord-312001-8p7scli8	280	11	by	by	IN
cord-312001-8p7scli8	280	12	numerous	numerous	JJ
cord-312001-8p7scli8	280	13	viral	viral	JJ
cord-312001-8p7scli8	280	14	proteases	protease	NNS
cord-312001-8p7scli8	280	15	,	,	,
cord-312001-8p7scli8	280	16	such	such	JJ
cord-312001-8p7scli8	280	17	as	as	IN
cord-312001-8p7scli8	280	18	3Cpro	3cpro	CD
cord-312001-8p7scli8	280	19	from	from	IN
cord-312001-8p7scli8	280	20	HAV	HAV	NNP
cord-312001-8p7scli8	280	21	,	,	,
cord-312001-8p7scli8	280	22	2Apro	2apro	CD
cord-312001-8p7scli8	280	23	from	from	IN
cord-312001-8p7scli8	280	24	EV71	EV71	NNP
cord-312001-8p7scli8	280	25	,	,	,
cord-312001-8p7scli8	280	26	NS3-NS4A	NS3-NS4A	NNP
cord-312001-8p7scli8	280	27	from	from	IN
cord-312001-8p7scli8	280	28	HCV	HCV	NNP
cord-312001-8p7scli8	280	29	,	,	,
cord-312001-8p7scli8	280	30	2Apro	2Apro	NNP
cord-312001-8p7scli8	280	31	and	and	CC
cord-312001-8p7scli8	280	32	3Cpro	3cpro	CD
cord-312001-8p7scli8	280	33	from	from	IN
cord-312001-8p7scli8	280	34	rhinovirus	rhinovirus	NN
cord-312001-8p7scli8	280	35	and	and	CC
cord-312001-8p7scli8	280	36	3Cpro	3cpro	CD
cord-312001-8p7scli8	280	37	from	from	IN
cord-312001-8p7scli8	280	38	coxsackievirus	coxsackievirus	NNP
cord-312001-8p7scli8	280	39	B3	B3	NNP
cord-312001-8p7scli8	280	40	(	(	-LRB-
cord-312001-8p7scli8	280	41	CVB3	CVB3	NNP
cord-312001-8p7scli8	280	42	)	)	-RRB-
cord-312001-8p7scli8	280	43	[	[	-LRB-
cord-312001-8p7scli8	280	44	184	184	CD
cord-312001-8p7scli8	280	45	,	,	,
cord-312001-8p7scli8	280	46	185	185	CD
cord-312001-8p7scli8	280	47	,	,	,
cord-312001-8p7scli8	280	48	[	[	-LRB-
cord-312001-8p7scli8	280	49	194	194	CD
cord-312001-8p7scli8	280	50	]	]	-RRB-
cord-312001-8p7scli8	280	51	[	[	-LRB-
cord-312001-8p7scli8	280	52	195	195	CD
cord-312001-8p7scli8	280	53	]	]	-RRB-
cord-312001-8p7scli8	280	54	[	[	-LRB-
cord-312001-8p7scli8	280	55	196	196	CD
cord-312001-8p7scli8	280	56	]	]	-RRB-
cord-312001-8p7scli8	280	57	.	.	.
cord-312001-8p7scli8	281	1	MAVS	MAVS	NNP
cord-312001-8p7scli8	281	2	can	can	MD
cord-312001-8p7scli8	281	3	also	also	RB
cord-312001-8p7scli8	281	4	be	be	VB
cord-312001-8p7scli8	281	5	indirectly	indirectly	RB
cord-312001-8p7scli8	281	6	degraded	degrade	VBN
cord-312001-8p7scli8	281	7	by	by	IN
cord-312001-8p7scli8	281	8	particular	particular	JJ
cord-312001-8p7scli8	281	9	viruses	virus	NNS
cord-312001-8p7scli8	281	10	.	.	.
cord-312001-8p7scli8	282	1	For	for	IN
cord-312001-8p7scli8	282	2	instance	instance	NN
cord-312001-8p7scli8	282	3	,	,	,
cord-312001-8p7scli8	282	4	measles	measles	NN
cord-312001-8p7scli8	282	5	virus	virus	NN
cord-312001-8p7scli8	282	6	(	(	-LRB-
cord-312001-8p7scli8	282	7	MeV	MeV	NNP
cord-312001-8p7scli8	282	8	)	)	-RRB-
cord-312001-8p7scli8	282	9	can	can	MD
cord-312001-8p7scli8	282	10	trigger	trigger	VB
cord-312001-8p7scli8	282	11	a	a	DT
cord-312001-8p7scli8	282	12	selective	selective	JJ
cord-312001-8p7scli8	282	13	form	form	NN
cord-312001-8p7scli8	282	14	of	of	IN
cord-312001-8p7scli8	282	15	autophagy	autophagy	NN
cord-312001-8p7scli8	282	16	,	,	,
cord-312001-8p7scli8	282	17	called	call	VBN
cord-312001-8p7scli8	282	18	mitophagy	mitophagy	NNP
cord-312001-8p7scli8	282	19	,	,	,
cord-312001-8p7scli8	282	20	responsible	responsible	JJ
cord-312001-8p7scli8	282	21	for	for	IN
cord-312001-8p7scli8	282	22	the	the	DT
cord-312001-8p7scli8	282	23	degradation	degradation	NN
cord-312001-8p7scli8	282	24	of	of	IN
cord-312001-8p7scli8	282	25	mitochondria	mitochondrion	NNS
cord-312001-8p7scli8	282	26	,	,	,
cord-312001-8p7scli8	282	27	which	which	WDT
cord-312001-8p7scli8	282	28	leads	lead	VBZ
cord-312001-8p7scli8	282	29	to	to	IN
cord-312001-8p7scli8	282	30	a	a	DT
cord-312001-8p7scli8	282	31	decrease	decrease	NN
cord-312001-8p7scli8	282	32	of	of	IN
cord-312001-8p7scli8	282	33	MAVS	MAVS	NNP
cord-312001-8p7scli8	282	34	abundance	abundance	VBZ
cord-312001-8p7scli8	282	35	[	[	-LRB-
cord-312001-8p7scli8	282	36	197	197	CD
cord-312001-8p7scli8	282	37	]	]	-RRB-
cord-312001-8p7scli8	282	38	.	.	.
cord-312001-8p7scli8	283	1	Another	another	DT
cord-312001-8p7scli8	283	2	example	example	NN
cord-312001-8p7scli8	283	3	of	of	IN
cord-312001-8p7scli8	283	4	indirect	indirect	JJ
cord-312001-8p7scli8	283	5	MAVS	MAVS	NNP
cord-312001-8p7scli8	283	6	degradation	degradation	NN
cord-312001-8p7scli8	283	7	comes	come	VBZ
cord-312001-8p7scli8	283	8	from	from	IN
cord-312001-8p7scli8	283	9	studies	study	NNS
cord-312001-8p7scli8	283	10	with	with	IN
cord-312001-8p7scli8	283	11	severe	severe	JJ
cord-312001-8p7scli8	283	12	acute	acute	JJ
cord-312001-8p7scli8	283	13	respiratory	respiratory	JJ
cord-312001-8p7scli8	283	14	syndrome	syndrome	NN
cord-312001-8p7scli8	283	15	(	(	-LRB-
cord-312001-8p7scli8	283	16	SARS)-associated	sars)-associated	CD
cord-312001-8p7scli8	283	17	coronavirus	coronavirus	NN
cord-312001-8p7scli8	283	18	(	(	-LRB-
cord-312001-8p7scli8	283	19	SARS	SARS	NNP
cord-312001-8p7scli8	283	20	-	-	HYPH
cord-312001-8p7scli8	283	21	CoV	CoV	NNP
cord-312001-8p7scli8	283	22	)	)	-RRB-
cord-312001-8p7scli8	283	23	.	.	.
cord-312001-8p7scli8	284	1	This	this	DT
cord-312001-8p7scli8	284	2	virus	virus	NN
cord-312001-8p7scli8	284	3	has	have	VBZ
cord-312001-8p7scli8	284	4	evolved	evolve	VBN
cord-312001-8p7scli8	284	5	a	a	DT
cord-312001-8p7scli8	284	6	strategy	strategy	NN
cord-312001-8p7scli8	284	7	in	in	IN
cord-312001-8p7scli8	284	8	which	which	WDT
cord-312001-8p7scli8	284	9	its	-PRON-	PRP$
cord-312001-8p7scli8	284	10	9b	9b	NNS
cord-312001-8p7scli8	284	11	protein	protein	NN
cord-312001-8p7scli8	284	12	localizes	localize	VBZ
cord-312001-8p7scli8	284	13	to	to	IN
cord-312001-8p7scli8	284	14	mitochondria	mitochondrion	NNS
cord-312001-8p7scli8	284	15	and	and	CC
cord-312001-8p7scli8	284	16	subverts	subvert	VBZ
cord-312001-8p7scli8	284	17	the	the	DT
cord-312001-8p7scli8	284	18	cellular	cellular	JJ
cord-312001-8p7scli8	284	19	E3	e3	NN
cord-312001-8p7scli8	284	20	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	284	21	ligase	ligase	NN
cord-312001-8p7scli8	284	22	atrophin-1-interacting	atrophin-1-interacte	VBG
cord-312001-8p7scli8	284	23	protein	protein	NN
cord-312001-8p7scli8	284	24	4	4	CD
cord-312001-8p7scli8	284	25	(	(	-LRB-
cord-312001-8p7scli8	284	26	AIP4	AIP4	NNP
cord-312001-8p7scli8	284	27	)	)	-RRB-
cord-312001-8p7scli8	284	28	to	to	TO
cord-312001-8p7scli8	284	29	degrade	degrade	VB
cord-312001-8p7scli8	284	30	MAVS	MAVS	NNP
cord-312001-8p7scli8	284	31	[	[	-LRB-
cord-312001-8p7scli8	284	32	198	198	CD
cord-312001-8p7scli8	284	33	]	]	-RRB-
cord-312001-8p7scli8	284	34	.	.	.
cord-312001-8p7scli8	285	1	Post	post	JJ
cord-312001-8p7scli8	285	2	-	-	JJ
cord-312001-8p7scli8	285	3	translational	translational	JJ
cord-312001-8p7scli8	285	4	modifications	modification	NNS
cord-312001-8p7scli8	285	5	of	of	IN
cord-312001-8p7scli8	285	6	both	both	DT
cord-312001-8p7scli8	285	7	MAVS	MAVS	NNPS
cord-312001-8p7scli8	285	8	and	and	CC
cord-312001-8p7scli8	285	9	RLRs	rlr	NNS
cord-312001-8p7scli8	285	10	have	have	VBP
cord-312001-8p7scli8	285	11	also	also	RB
cord-312001-8p7scli8	285	12	been	be	VBN
cord-312001-8p7scli8	285	13	shown	show	VBN
cord-312001-8p7scli8	285	14	to	to	TO
cord-312001-8p7scli8	285	15	be	be	VB
cord-312001-8p7scli8	285	16	subverted	subvert	VBN
cord-312001-8p7scli8	285	17	by	by	IN
cord-312001-8p7scli8	285	18	viruses	virus	NNS
cord-312001-8p7scli8	285	19	to	to	TO
cord-312001-8p7scli8	285	20	inhibit	inhibit	VB
cord-312001-8p7scli8	285	21	their	-PRON-	PRP$
cord-312001-8p7scli8	285	22	downstream	downstream	JJ
cord-312001-8p7scli8	285	23	signaling	signaling	NN
cord-312001-8p7scli8	285	24	.	.	.
cord-312001-8p7scli8	286	1	NS1	ns1	NN
cord-312001-8p7scli8	286	2	proteins	protein	NNS
cord-312001-8p7scli8	286	3	from	from	IN
cord-312001-8p7scli8	286	4	many	many	JJ
cord-312001-8p7scli8	286	5	influenza	influenza	NN
cord-312001-8p7scli8	286	6	A	a	DT
cord-312001-8p7scli8	286	7	virus	virus	NN
cord-312001-8p7scli8	286	8	strains	strain	NNS
cord-312001-8p7scli8	286	9	(	(	-LRB-
cord-312001-8p7scli8	286	10	IAV	IAV	NNP
cord-312001-8p7scli8	286	11	)	)	-RRB-
cord-312001-8p7scli8	286	12	interact	interact	VB
cord-312001-8p7scli8	286	13	with	with	IN
cord-312001-8p7scli8	286	14	the	the	DT
cord-312001-8p7scli8	286	15	host	host	NN
cord-312001-8p7scli8	286	16	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	286	17	ligase	ligase	NN
cord-312001-8p7scli8	286	18	TRIM25	TRIM25	NNP
cord-312001-8p7scli8	286	19	and	and	CC
cord-312001-8p7scli8	286	20	inhibit	inhibit	VB
cord-312001-8p7scli8	286	21	its	-PRON-	PRP$
cord-312001-8p7scli8	286	22	oligomerization	oligomerization	NN
cord-312001-8p7scli8	286	23	,	,	,
cord-312001-8p7scli8	286	24	a	a	DT
cord-312001-8p7scli8	286	25	crucial	crucial	JJ
cord-312001-8p7scli8	286	26	step	step	NN
cord-312001-8p7scli8	286	27	for	for	IN
cord-312001-8p7scli8	286	28	its	-PRON-	PRP$
cord-312001-8p7scli8	286	29	enzymatic	enzymatic	JJ
cord-312001-8p7scli8	286	30	activity	activity	NN
cord-312001-8p7scli8	286	31	of	of	IN
cord-312001-8p7scli8	286	32	attaching	attach	VBG
cord-312001-8p7scli8	286	33	Lys63-linked	lys63-linked	IN
cord-312001-8p7scli8	286	34	polyubiquitin	polyubiquitin	NNS
cord-312001-8p7scli8	286	35	to	to	IN
cord-312001-8p7scli8	286	36	the	the	DT
cord-312001-8p7scli8	286	37	CARD	card	NN
cord-312001-8p7scli8	286	38	domains	domain	NNS
cord-312001-8p7scli8	286	39	of	of	IN
cord-312001-8p7scli8	286	40	RIG-	rig-	NN
cord-312001-8p7scli8	287	1	I	-PRON-	PRP
cord-312001-8p7scli8	287	2	[	[	-LRB-
cord-312001-8p7scli8	287	3	24	24	CD
cord-312001-8p7scli8	287	4	,	,	,
cord-312001-8p7scli8	287	5	199	199	CD
cord-312001-8p7scli8	287	6	]	]	-RRB-
cord-312001-8p7scli8	287	7	.	.	.
cord-312001-8p7scli8	288	1	Other	other	JJ
cord-312001-8p7scli8	288	2	viruses	virus	NNS
cord-312001-8p7scli8	288	3	encode	encode	VBP
cord-312001-8p7scli8	288	4	deubiquitinating	deubiquitinating	NN
cord-312001-8p7scli8	288	5	enzymes	enzyme	NNS
cord-312001-8p7scli8	288	6	(	(	-LRB-
cord-312001-8p7scli8	288	7	DUBs	dub	NNS
cord-312001-8p7scli8	288	8	)	)	-RRB-
cord-312001-8p7scli8	288	9	to	to	TO
cord-312001-8p7scli8	288	10	remove	remove	VB
cord-312001-8p7scli8	288	11	the	the	DT
cord-312001-8p7scli8	288	12	Lys63-linked	lys63-linked	NN
cord-312001-8p7scli8	288	13	ubiquitination	ubiquitination	NN
cord-312001-8p7scli8	288	14	off	off	IN
cord-312001-8p7scli8	288	15	RIG	rig	NN
cord-312001-8p7scli8	288	16	-	-	HYPH
cord-312001-8p7scli8	288	17	I.	i.	NN
cord-312001-8p7scli8	288	18	ORF64	ORF64	NNP
cord-312001-8p7scli8	288	19	from	from	IN
cord-312001-8p7scli8	288	20	Kaposi	Kaposi	NNP
cord-312001-8p7scli8	288	21	's	's	POS
cord-312001-8p7scli8	288	22	sarcoma	sarcoma	NN
cord-312001-8p7scli8	288	23	herpesvirus	herpesvirus	NN
cord-312001-8p7scli8	288	24	(	(	-LRB-
cord-312001-8p7scli8	288	25	KSHV	KSHV	NNP
cord-312001-8p7scli8	288	26	)	)	-RRB-
cord-312001-8p7scli8	288	27	,	,	,
cord-312001-8p7scli8	288	28	papain	papain	NN
cord-312001-8p7scli8	288	29	-	-	HYPH
cord-312001-8p7scli8	288	30	like	like	JJ
cord-312001-8p7scli8	288	31	protease	protease	NN
cord-312001-8p7scli8	288	32	(	(	-LRB-
cord-312001-8p7scli8	288	33	PLP	PLP	NNP
cord-312001-8p7scli8	288	34	)	)	-RRB-
cord-312001-8p7scli8	288	35	from	from	IN
cord-312001-8p7scli8	288	36	SARS	SARS	NNP
cord-312001-8p7scli8	288	37	-	-	HYPH
cord-312001-8p7scli8	288	38	CoV	CoV	NNP
cord-312001-8p7scli8	288	39	,	,	,
cord-312001-8p7scli8	288	40	leader	leader	NN
cord-312001-8p7scli8	288	41	proteinase	proteinase	NN
cord-312001-8p7scli8	288	42	(	(	-LRB-
cord-312001-8p7scli8	288	43	Lpro	Lpro	NNP
cord-312001-8p7scli8	288	44	)	)	-RRB-
cord-312001-8p7scli8	288	45	from	from	IN
cord-312001-8p7scli8	288	46	foot	foot	NN
cord-312001-8p7scli8	288	47	-	-	HYPH
cord-312001-8p7scli8	288	48	and	and	CC
cord-312001-8p7scli8	288	49	-	-	HYPH
cord-312001-8p7scli8	288	50	mouth	mouth	NN
cord-312001-8p7scli8	288	51	disease	disease	NN
cord-312001-8p7scli8	288	52	virus	virus	NN
cord-312001-8p7scli8	288	53	(	(	-LRB-
cord-312001-8p7scli8	288	54	FMDV	FMDV	NNP
cord-312001-8p7scli8	288	55	)	)	-RRB-
cord-312001-8p7scli8	288	56	and	and	CC
cord-312001-8p7scli8	288	57	the	the	DT
cord-312001-8p7scli8	288	58	ovarian	ovarian	JJ
cord-312001-8p7scli8	288	59	tumor	tumor	NN
cord-312001-8p7scli8	288	60	(	(	-LRB-
cord-312001-8p7scli8	288	61	OTU)-type	otu)-type	NN
cord-312001-8p7scli8	288	62	proteins	protein	NNS
cord-312001-8p7scli8	288	63	of	of	IN
cord-312001-8p7scli8	288	64	arteriviruses	arteriviruse	NNS
cord-312001-8p7scli8	288	65	and	and	CC
cord-312001-8p7scli8	288	66	nairoviruses	nairoviruses	NNPS
cord-312001-8p7scli8	288	67	have	have	VBP
cord-312001-8p7scli8	288	68	all	all	DT
cord-312001-8p7scli8	288	69	been	be	VBN
cord-312001-8p7scli8	288	70	shown	show	VBN
cord-312001-8p7scli8	288	71	to	to	TO
cord-312001-8p7scli8	288	72	possess	possess	VB
cord-312001-8p7scli8	288	73	a	a	DT
cord-312001-8p7scli8	288	74	deubiquitination	deubiquitination	NN
cord-312001-8p7scli8	288	75	activity	activity	NN
cord-312001-8p7scli8	288	76	and	and	CC
cord-312001-8p7scli8	288	77	interfere	interfere	VB
cord-312001-8p7scli8	288	78	with	with	IN
cord-312001-8p7scli8	288	79	RIG	rig	NN
cord-312001-8p7scli8	289	1	-I	-i	DT
cord-312001-8p7scli8	289	2	mediated	mediate	VBN
cord-312001-8p7scli8	289	3	signaling	signal	VBG
cord-312001-8p7scli8	289	4	[	[	-LRB-
cord-312001-8p7scli8	289	5	177	177	CD
cord-312001-8p7scli8	289	6	,	,	,
cord-312001-8p7scli8	289	7	[	[	-LRB-
cord-312001-8p7scli8	289	8	200	200	CD
cord-312001-8p7scli8	289	9	]	]	-RRB-
cord-312001-8p7scli8	289	10	[	[	-LRB-
cord-312001-8p7scli8	289	11	201	201	CD
cord-312001-8p7scli8	289	12	]	]	-RRB-
cord-312001-8p7scli8	289	13	[	[	-LRB-
cord-312001-8p7scli8	289	14	202	202	CD
cord-312001-8p7scli8	289	15	]	]	-RRB-
cord-312001-8p7scli8	289	16	.	.	.
cord-312001-8p7scli8	290	1	RIG	rig	NN
cord-312001-8p7scli8	290	2	-	-	:
cord-312001-8p7scli8	290	3	I	I	NNP
cord-312001-8p7scli8	290	4	and	and	CC
cord-312001-8p7scli8	290	5	MDA5	mda5	JJ
cord-312001-8p7scli8	290	6	phosphorylation	phosphorylation	NN
cord-312001-8p7scli8	290	7	status	status	NN
cord-312001-8p7scli8	290	8	can	can	MD
cord-312001-8p7scli8	290	9	also	also	RB
cord-312001-8p7scli8	290	10	be	be	VB
cord-312001-8p7scli8	290	11	subverted	subvert	VBN
cord-312001-8p7scli8	290	12	by	by	IN
cord-312001-8p7scli8	290	13	viruses	virus	NNS
cord-312001-8p7scli8	290	14	.	.	.
cord-312001-8p7scli8	291	1	In	in	IN
cord-312001-8p7scli8	291	2	normal	normal	JJ
cord-312001-8p7scli8	291	3	conditions	condition	NNS
cord-312001-8p7scli8	291	4	,	,	,
cord-312001-8p7scli8	291	5	phosphorylation	phosphorylation	NN
cord-312001-8p7scli8	291	6	of	of	IN
cord-312001-8p7scli8	291	7	serine	serine	NN
cord-312001-8p7scli8	291	8	or	or	CC
cord-312001-8p7scli8	291	9	threonine	threonine	NN
cord-312001-8p7scli8	291	10	residues	residue	NNS
cord-312001-8p7scli8	291	11	keeps	keep	VBZ
cord-312001-8p7scli8	291	12	RIG	rig	NN
cord-312001-8p7scli8	291	13	-	-	:
cord-312001-8p7scli8	291	14	I	I	NNP
cord-312001-8p7scli8	291	15	and	and	CC
cord-312001-8p7scli8	291	16	MDA5	MDA5	NNP
cord-312001-8p7scli8	291	17	in	in	IN
cord-312001-8p7scli8	291	18	an	an	DT
cord-312001-8p7scli8	291	19	inactive	inactive	JJ
cord-312001-8p7scli8	291	20	state	state	NN
cord-312001-8p7scli8	291	21	.	.	.
cord-312001-8p7scli8	292	1	Upon	upon	IN
cord-312001-8p7scli8	292	2	viral	viral	JJ
cord-312001-8p7scli8	292	3	infection	infection	NN
cord-312001-8p7scli8	292	4	,	,	,
cord-312001-8p7scli8	292	5	PP1	PP1	NNP
cord-312001-8p7scli8	292	6	phosphatases	phosphatase	NNS
cord-312001-8p7scli8	292	7	are	be	VBP
cord-312001-8p7scli8	292	8	recruited	recruit	VBN
cord-312001-8p7scli8	292	9	to	to	TO
cord-312001-8p7scli8	292	10	dephosphorylate	dephosphorylate	VB
cord-312001-8p7scli8	292	11	specific	specific	JJ
cord-312001-8p7scli8	292	12	marks	mark	NNS
cord-312001-8p7scli8	292	13	on	on	IN
cord-312001-8p7scli8	292	14	those	those	DT
cord-312001-8p7scli8	292	15	receptors	receptor	NNS
cord-312001-8p7scli8	292	16	and	and	CC
cord-312001-8p7scli8	292	17	activate	activate	VB
cord-312001-8p7scli8	292	18	them	-PRON-	PRP
cord-312001-8p7scli8	292	19	.	.	.
cord-312001-8p7scli8	293	1	V	v	LS
cord-312001-8p7scli8	293	2	proteins	protein	NNS
cord-312001-8p7scli8	293	3	from	from	IN
cord-312001-8p7scli8	293	4	Measles	Measles	NNP
cord-312001-8p7scli8	293	5	and	and	CC
cord-312001-8p7scli8	293	6	Nipah	Nipah	NNP
cord-312001-8p7scli8	293	7	viruses	virus	NNS
cord-312001-8p7scli8	293	8	(	(	-LRB-
cord-312001-8p7scli8	293	9	MeV	MeV	NNP
cord-312001-8p7scli8	293	10	and	and	CC
cord-312001-8p7scli8	293	11	NiV	NiV	NNP
cord-312001-8p7scli8	293	12	)	)	-RRB-
cord-312001-8p7scli8	293	13	act	act	VBP
cord-312001-8p7scli8	293	14	as	as	IN
cord-312001-8p7scli8	293	15	decoys	decoy	NNS
cord-312001-8p7scli8	293	16	and	and	CC
cord-312001-8p7scli8	293	17	have	have	VBP
cord-312001-8p7scli8	293	18	been	be	VBN
cord-312001-8p7scli8	293	19	shown	show	VBN
cord-312001-8p7scli8	293	20	to	to	TO
cord-312001-8p7scli8	293	21	bind	bind	VB
cord-312001-8p7scli8	293	22	PP1-α	PP1-α	NNP
cord-312001-8p7scli8	293	23	and	and	CC
cord-312001-8p7scli8	293	24	PP1-γ	PP1-γ	NNP
cord-312001-8p7scli8	293	25	,	,	,
cord-312001-8p7scli8	293	26	sequestering	sequester	VBG
cord-312001-8p7scli8	293	27	them	-PRON-	PRP
cord-312001-8p7scli8	293	28	away	away	RB
cord-312001-8p7scli8	293	29	from	from	IN
cord-312001-8p7scli8	293	30	MDA5	MDA5	NNP
cord-312001-8p7scli8	293	31	and	and	CC
cord-312001-8p7scli8	293	32	RIG	rig	NN
cord-312001-8p7scli8	294	1	-I	-I	NFP
cord-312001-8p7scli8	294	2	[	[	-LRB-
cord-312001-8p7scli8	294	3	203	203	CD
cord-312001-8p7scli8	294	4	,	,	,
cord-312001-8p7scli8	294	5	204	204	CD
cord-312001-8p7scli8	294	6	]	]	-RRB-
cord-312001-8p7scli8	294	7	.	.	.
cord-312001-8p7scli8	295	1	Similar	similar	JJ
cord-312001-8p7scli8	295	2	to	to	IN
cord-312001-8p7scli8	295	3	evasion	evasion	NN
cord-312001-8p7scli8	295	4	strategies	strategy	NNS
cord-312001-8p7scli8	295	5	that	that	WDT
cord-312001-8p7scli8	295	6	counter	counter	VBP
cord-312001-8p7scli8	295	7	the	the	DT
cord-312001-8p7scli8	295	8	RNA	RNA	NNP
cord-312001-8p7scli8	295	9	sensing	sensing	NN
cord-312001-8p7scli8	295	10	machinery	machinery	NN
cord-312001-8p7scli8	295	11	described	describe	VBN
cord-312001-8p7scli8	295	12	earlier	early	RBR
cord-312001-8p7scli8	295	13	,	,	,
cord-312001-8p7scli8	295	14	DNA	dna	NN
cord-312001-8p7scli8	295	15	viruses	virus	NNS
cord-312001-8p7scli8	295	16	use	use	VBP
cord-312001-8p7scli8	295	17	numerous	numerous	JJ
cord-312001-8p7scli8	295	18	strategies	strategy	NNS
cord-312001-8p7scli8	295	19	to	to	TO
cord-312001-8p7scli8	295	20	escape	escape	VB
cord-312001-8p7scli8	295	21	cGAS	cgas	JJ
cord-312001-8p7scli8	295	22	-	-	HYPH
cord-312001-8p7scli8	295	23	STING	sting	NN
cord-312001-8p7scli8	295	24	-	-	HYPH
cord-312001-8p7scli8	295	25	dependent	dependent	JJ
cord-312001-8p7scli8	295	26	detection	detection	NN
cord-312001-8p7scli8	295	27	and	and	CC
cord-312001-8p7scli8	295	28	signaling	signaling	NN
cord-312001-8p7scli8	295	29	.	.	.
cord-312001-8p7scli8	296	1	They	-PRON-	PRP
cord-312001-8p7scli8	296	2	could	could	MD
cord-312001-8p7scli8	296	3	either	either	CC
cord-312001-8p7scli8	296	4	hide	hide	VB
cord-312001-8p7scli8	296	5	their	-PRON-	PRP$
cord-312001-8p7scli8	296	6	viral	viral	JJ
cord-312001-8p7scli8	296	7	genomes	genome	NNS
cord-312001-8p7scli8	296	8	or	or	CC
cord-312001-8p7scli8	296	9	cleave	cleave	VBP
cord-312001-8p7scli8	296	10	,	,	,
cord-312001-8p7scli8	296	11	degrade	degrade	VB
cord-312001-8p7scli8	296	12	,	,	,
cord-312001-8p7scli8	296	13	post	post	VB
cord-312001-8p7scli8	296	14	-	-	NN
cord-312001-8p7scli8	296	15	translationally	translationally	RB
cord-312001-8p7scli8	296	16	modify	modify	VB
cord-312001-8p7scli8	296	17	or	or	CC
cord-312001-8p7scli8	296	18	even	even	RB
cord-312001-8p7scli8	296	19	relocalize	relocalize	NNP
cord-312001-8p7scli8	296	20	DNA	dna	NN
cord-312001-8p7scli8	296	21	sensing	sensing	NN
cord-312001-8p7scli8	296	22	and	and	CC
cord-312001-8p7scli8	296	23	signaling	signal	VBG
cord-312001-8p7scli8	296	24	factors	factor	NNS
cord-312001-8p7scli8	296	25	[	[	-LRB-
cord-312001-8p7scli8	296	26	205	205	CD
cord-312001-8p7scli8	296	27	]	]	-RRB-
cord-312001-8p7scli8	296	28	.	.	.
cord-312001-8p7scli8	297	1	Hepatitis	Hepatitis	NNP
cord-312001-8p7scli8	297	2	B	B	NNP
cord-312001-8p7scli8	297	3	Virus	Virus	NNP
cord-312001-8p7scli8	297	4	(	(	-LRB-
cord-312001-8p7scli8	297	5	HBV	HBV	NNP
cord-312001-8p7scli8	297	6	)	)	-RRB-
cord-312001-8p7scli8	297	7	,	,	,
cord-312001-8p7scli8	297	8	that	that	WDT
cord-312001-8p7scli8	297	9	causes	cause	VBZ
cord-312001-8p7scli8	297	10	chronic	chronic	JJ
cord-312001-8p7scli8	297	11	hepatitis	hepatitis	NN
cord-312001-8p7scli8	297	12	and	and	CC
cord-312001-8p7scli8	297	13	increases	increase	VBZ
cord-312001-8p7scli8	297	14	the	the	DT
cord-312001-8p7scli8	297	15	risk	risk	NN
cord-312001-8p7scli8	297	16	of	of	IN
cord-312001-8p7scli8	297	17	developing	develop	VBG
cord-312001-8p7scli8	297	18	liver	liver	NN
cord-312001-8p7scli8	297	19	cirrhosis	cirrhosis	NN
cord-312001-8p7scli8	297	20	and	and	CC
cord-312001-8p7scli8	297	21	hepatocellular	hepatocellular	JJ
cord-312001-8p7scli8	297	22	carcinoma	carcinoma	NN
cord-312001-8p7scli8	297	23	,	,	,
cord-312001-8p7scli8	297	24	has	have	VBZ
cord-312001-8p7scli8	297	25	developed	develop	VBN
cord-312001-8p7scli8	297	26	an	an	DT
cord-312001-8p7scli8	297	27	array	array	NN
cord-312001-8p7scli8	297	28	of	of	IN
cord-312001-8p7scli8	297	29	mechanisms	mechanism	NNS
cord-312001-8p7scli8	297	30	to	to	TO
cord-312001-8p7scli8	297	31	inhibit	inhibit	VB
cord-312001-8p7scli8	297	32	the	the	DT
cord-312001-8p7scli8	297	33	host	host	NN
cord-312001-8p7scli8	297	34	's	's	POS
cord-312001-8p7scli8	297	35	immune	immune	JJ
cord-312001-8p7scli8	297	36	systems	system	NNS
cord-312001-8p7scli8	297	37	(	(	-LRB-
cord-312001-8p7scli8	297	38	reviewed	review	VBN
cord-312001-8p7scli8	297	39	in	in	IN
cord-312001-8p7scli8	297	40	[	[	-LRB-
cord-312001-8p7scli8	297	41	206	206	CD
cord-312001-8p7scli8	297	42	]	]	-RRB-
cord-312001-8p7scli8	297	43	)	)	-RRB-
cord-312001-8p7scli8	297	44	.	.	.
cord-312001-8p7scli8	298	1	Notably	notably	RB
cord-312001-8p7scli8	298	2	,	,	,
cord-312001-8p7scli8	298	3	the	the	DT
cord-312001-8p7scli8	298	4	HBV	HBV	NNP
cord-312001-8p7scli8	298	5	polymerase	polymerase	NN
cord-312001-8p7scli8	298	6	can	can	MD
cord-312001-8p7scli8	298	7	bind	bind	VB
cord-312001-8p7scli8	298	8	to	to	TO
cord-312001-8p7scli8	298	9	STING	sting	VB
cord-312001-8p7scli8	298	10	to	to	TO
cord-312001-8p7scli8	298	11	block	block	VB
cord-312001-8p7scli8	298	12	its	-PRON-	PRP$
cord-312001-8p7scli8	298	13	Lys63-linked	lys63-linked	NN
cord-312001-8p7scli8	298	14	ubiquitination	ubiquitination	NN
cord-312001-8p7scli8	298	15	,	,	,
cord-312001-8p7scli8	298	16	inhibiting	inhibit	VBG
cord-312001-8p7scli8	298	17	the	the	DT
cord-312001-8p7scli8	298	18	production	production	NN
cord-312001-8p7scli8	298	19	of	of	IN
cord-312001-8p7scli8	298	20	IFN	IFN	NNP
cord-312001-8p7scli8	298	21	-	-	HYPH
cord-312001-8p7scli8	298	22	β	β	NNP
cord-312001-8p7scli8	298	23	[	[	-LRB-
cord-312001-8p7scli8	298	24	207	207	CD
cord-312001-8p7scli8	298	25	]	]	-RRB-
cord-312001-8p7scli8	298	26	.	.	.
cord-312001-8p7scli8	299	1	Moreover	moreover	RB
cord-312001-8p7scli8	299	2	,	,	,
cord-312001-8p7scli8	299	3	even	even	RB
cord-312001-8p7scli8	299	4	though	though	IN
cord-312001-8p7scli8	299	5	cGAS	cgas	NN
cord-312001-8p7scli8	299	6	is	be	VBZ
cord-312001-8p7scli8	299	7	expressed	express	VBN
cord-312001-8p7scli8	299	8	in	in	IN
cord-312001-8p7scli8	299	9	human	human	JJ
cord-312001-8p7scli8	299	10	hepatocytes	hepatocyte	NNS
cord-312001-8p7scli8	299	11	and	and	CC
cord-312001-8p7scli8	299	12	is	be	VBZ
cord-312001-8p7scli8	299	13	able	able	JJ
cord-312001-8p7scli8	299	14	to	to	TO
cord-312001-8p7scli8	299	15	sense	sense	VB
cord-312001-8p7scli8	299	16	and	and	CC
cord-312001-8p7scli8	299	17	signal	signal	NN
cord-312001-8p7scli8	299	18	upon	upon	IN
cord-312001-8p7scli8	299	19	transfection	transfection	NN
cord-312001-8p7scli8	299	20	of	of	IN
cord-312001-8p7scli8	299	21	naked	naked	JJ
cord-312001-8p7scli8	299	22	relaxed	relaxed	JJ
cord-312001-8p7scli8	299	23	-	-	HYPH
cord-312001-8p7scli8	299	24	circular	circular	JJ
cord-312001-8p7scli8	299	25	HBV	HBV	NNP
cord-312001-8p7scli8	299	26	DNA	DNA	NNP
cord-312001-8p7scli8	299	27	;	;	:
cord-312001-8p7scli8	299	28	during	during	IN
cord-312001-8p7scli8	299	29	a	a	DT
cord-312001-8p7scli8	299	30	natural	natural	JJ
cord-312001-8p7scli8	299	31	infection	infection	NN
cord-312001-8p7scli8	299	32	,	,	,
cord-312001-8p7scli8	299	33	HBV	HBV	NNP
cord-312001-8p7scli8	299	34	DNA	DNA	NNP
cord-312001-8p7scli8	299	35	seems	seem	VBZ
cord-312001-8p7scli8	299	36	to	to	TO
cord-312001-8p7scli8	299	37	escape	escape	VB
cord-312001-8p7scli8	299	38	cGAS	cgas	JJ
cord-312001-8p7scli8	299	39	detection	detection	NN
cord-312001-8p7scli8	299	40	,	,	,
cord-312001-8p7scli8	299	41	likely	likely	RB
cord-312001-8p7scli8	299	42	due	due	IN
cord-312001-8p7scli8	299	43	to	to	IN
cord-312001-8p7scli8	299	44	packaging	packaging	NN
cord-312001-8p7scli8	299	45	of	of	IN
cord-312001-8p7scli8	299	46	the	the	DT
cord-312001-8p7scli8	299	47	genome	genome	NN
cord-312001-8p7scli8	299	48	into	into	IN
cord-312001-8p7scli8	299	49	the	the	DT
cord-312001-8p7scli8	299	50	viral	viral	JJ
cord-312001-8p7scli8	299	51	capsid	capsid	NN
cord-312001-8p7scli8	299	52	[	[	-LRB-
cord-312001-8p7scli8	299	53	208	208	CD
cord-312001-8p7scli8	299	54	]	]	-RRB-
cord-312001-8p7scli8	299	55	.	.	.
cord-312001-8p7scli8	300	1	KSHV	KSHV	NNP
cord-312001-8p7scli8	300	2	,	,	,
cord-312001-8p7scli8	300	3	another	another	DT
cord-312001-8p7scli8	300	4	DNA	dna	NN
cord-312001-8p7scli8	300	5	virus	virus	NN
cord-312001-8p7scli8	300	6	has	have	VBZ
cord-312001-8p7scli8	300	7	been	be	VBN
cord-312001-8p7scli8	300	8	shown	show	VBN
cord-312001-8p7scli8	300	9	to	to	TO
cord-312001-8p7scli8	300	10	act	act	VB
cord-312001-8p7scli8	300	11	on	on	IN
cord-312001-8p7scli8	300	12	both	both	CC
cord-312001-8p7scli8	300	13	cGAS	cgas	JJ
cord-312001-8p7scli8	300	14	and	and	CC
cord-312001-8p7scli8	300	15	STING	sting	NN
cord-312001-8p7scli8	300	16	.	.	.
cord-312001-8p7scli8	301	1	Several	several	JJ
cord-312001-8p7scli8	301	2	KSHV	KSHV	NNP
cord-312001-8p7scli8	301	3	proteins	protein	NNS
cord-312001-8p7scli8	301	4	(	(	-LRB-
cord-312001-8p7scli8	301	5	e.g.	e.g.	RB
cord-312001-8p7scli8	301	6	,	,	,
cord-312001-8p7scli8	301	7	ORF52	ORF52	NNP
cord-312001-8p7scli8	301	8	and	and	CC
cord-312001-8p7scli8	301	9	LANA	LANA	NNP
cord-312001-8p7scli8	301	10	)	)	-RRB-
cord-312001-8p7scli8	302	1	can	can	MD
cord-312001-8p7scli8	302	2	either	either	CC
cord-312001-8p7scli8	302	3	sequestrate	sequestrate	VB
cord-312001-8p7scli8	302	4	stimulatory	stimulatory	JJ
cord-312001-8p7scli8	302	5	DNA	dna	NN
cord-312001-8p7scli8	302	6	or	or	CC
cord-312001-8p7scli8	302	7	directly	directly	RB
cord-312001-8p7scli8	302	8	bind	bind	VB
cord-312001-8p7scli8	302	9	to	to	IN
cord-312001-8p7scli8	302	10	cGAS	cgas	VB
cord-312001-8p7scli8	302	11	inhibiting	inhibit	VBG
cord-312001-8p7scli8	302	12	its	-PRON-	PRP$
cord-312001-8p7scli8	302	13	enzymatic	enzymatic	JJ
cord-312001-8p7scli8	302	14	activity	activity	NN
cord-312001-8p7scli8	302	15	[	[	-LRB-
cord-312001-8p7scli8	302	16	209	209	CD
cord-312001-8p7scli8	302	17	,	,	,
cord-312001-8p7scli8	302	18	210	210	CD
cord-312001-8p7scli8	302	19	]	]	-RRB-
cord-312001-8p7scli8	302	20	.	.	.
cord-312001-8p7scli8	303	1	KSHV	KSHV	NNP
cord-312001-8p7scli8	303	2	has	have	VBZ
cord-312001-8p7scli8	303	3	been	be	VBN
cord-312001-8p7scli8	303	4	also	also	RB
cord-312001-8p7scli8	303	5	shown	show	VBN
cord-312001-8p7scli8	303	6	to	to	TO
cord-312001-8p7scli8	303	7	encode	encode	VB
cord-312001-8p7scli8	303	8	a	a	DT
cord-312001-8p7scli8	303	9	viral	viral	JJ
cord-312001-8p7scli8	303	10	interferon	interferon	NN
cord-312001-8p7scli8	303	11	regulatory	regulatory	JJ
cord-312001-8p7scli8	303	12	factor	factor	NN
cord-312001-8p7scli8	303	13	(	(	-LRB-
cord-312001-8p7scli8	303	14	vIRF1	vIRF1	NNP
cord-312001-8p7scli8	303	15	)	)	-RRB-
cord-312001-8p7scli8	303	16	that	that	WDT
cord-312001-8p7scli8	303	17	interacts	interact	VBZ
cord-312001-8p7scli8	303	18	with	with	IN
cord-312001-8p7scli8	303	19	STING	sting	NN
cord-312001-8p7scli8	303	20	thereby	thereby	RB
cord-312001-8p7scli8	303	21	preventing	prevent	VBG
cord-312001-8p7scli8	303	22	TBK1	TBK1	NNP
cord-312001-8p7scli8	303	23	binding	binding	NN
cord-312001-8p7scli8	303	24	and	and	CC
cord-312001-8p7scli8	303	25	STING	sting	NN
cord-312001-8p7scli8	303	26	activation	activation	NN
cord-312001-8p7scli8	303	27	by	by	IN
cord-312001-8p7scli8	303	28	TBK1-dependent	TBK1-dependent	NNP
cord-312001-8p7scli8	303	29	phosphorylation	phosphorylation	NN
cord-312001-8p7scli8	303	30	[	[	-LRB-
cord-312001-8p7scli8	303	31	211	211	CD
cord-312001-8p7scli8	303	32	]	]	-RRB-
cord-312001-8p7scli8	303	33	.	.	.
cord-312001-8p7scli8	304	1	The	the	DT
cord-312001-8p7scli8	304	2	NS3	ns3	JJ
cord-312001-8p7scli8	304	3	protease	protease	NN
cord-312001-8p7scli8	304	4	of	of	IN
cord-312001-8p7scli8	304	5	DENV	DENV	NNP
cord-312001-8p7scli8	304	6	,	,	,
cord-312001-8p7scli8	304	7	together	together	RB
cord-312001-8p7scli8	304	8	with	with	IN
cord-312001-8p7scli8	304	9	its	-PRON-	PRP$
cord-312001-8p7scli8	304	10	NS2B	NS2B	NNP
cord-312001-8p7scli8	304	11	co	co	NN
cord-312001-8p7scli8	304	12	-	-	NN
cord-312001-8p7scli8	304	13	factor	factor	NN
cord-312001-8p7scli8	304	14	,	,	,
cord-312001-8p7scli8	304	15	has	have	VBZ
cord-312001-8p7scli8	304	16	been	be	VBN
cord-312001-8p7scli8	304	17	shown	show	VBN
cord-312001-8p7scli8	304	18	to	to	TO
cord-312001-8p7scli8	304	19	target	target	VB
cord-312001-8p7scli8	304	20	the	the	DT
cord-312001-8p7scli8	304	21	residues	residue	NNS
cord-312001-8p7scli8	304	22	93	93	CD
cord-312001-8p7scli8	304	23	-	-	HYPH
cord-312001-8p7scli8	304	24	96	96	CD
cord-312001-8p7scli8	304	25	(	(	-LRB-
cord-312001-8p7scli8	304	26	LRRG	LRRG	NNP
cord-312001-8p7scli8	304	27	)	)	-RRB-
cord-312001-8p7scli8	304	28	of	of	IN
cord-312001-8p7scli8	304	29	human	human	JJ
cord-312001-8p7scli8	304	30	STING	sting	NN
cord-312001-8p7scli8	304	31	,	,	,
cord-312001-8p7scli8	304	32	leading	lead	VBG
cord-312001-8p7scli8	304	33	to	to	IN
cord-312001-8p7scli8	304	34	its	-PRON-	PRP$
cord-312001-8p7scli8	304	35	cleavage	cleavage	NN
cord-312001-8p7scli8	304	36	and	and	CC
cord-312001-8p7scli8	304	37	degradation	degradation	NN
cord-312001-8p7scli8	304	38	[	[	-LRB-
cord-312001-8p7scli8	304	39	212	212	CD
cord-312001-8p7scli8	304	40	,	,	,
cord-312001-8p7scli8	304	41	213	213	CD
cord-312001-8p7scli8	304	42	]	]	-RRB-
cord-312001-8p7scli8	304	43	.	.	.
cord-312001-8p7scli8	305	1	Interestingly	interestingly	RB
cord-312001-8p7scli8	305	2	,	,	,
cord-312001-8p7scli8	305	3	mouse	mouse	NN
cord-312001-8p7scli8	305	4	STING	sting	NN
cord-312001-8p7scli8	305	5	lacks	lack	VBZ
cord-312001-8p7scli8	305	6	these	these	DT
cord-312001-8p7scli8	305	7	LRRG	LRRG	NNP
cord-312001-8p7scli8	305	8	residues	residue	NNS
cord-312001-8p7scli8	305	9	,	,	,
cord-312001-8p7scli8	305	10	and	and	CC
cord-312001-8p7scli8	305	11	NS2B	NS2B	NNP
cord-312001-8p7scli8	305	12	/	/	SYM
cord-312001-8p7scli8	305	13	NS3	ns3	RB
cord-312001-8p7scli8	305	14	of	of	IN
cord-312001-8p7scli8	305	15	DENV	DENV	NNP
cord-312001-8p7scli8	305	16	is	be	VBZ
cord-312001-8p7scli8	305	17	neither	neither	CC
cord-312001-8p7scli8	305	18	able	able	JJ
cord-312001-8p7scli8	305	19	to	to	TO
cord-312001-8p7scli8	305	20	cleave	cleave	VB
cord-312001-8p7scli8	305	21	the	the	DT
cord-312001-8p7scli8	305	22	murine	murine	JJ
cord-312001-8p7scli8	305	23	STING	sting	NN
cord-312001-8p7scli8	305	24	,	,	,
cord-312001-8p7scli8	305	25	nor	nor	CC
cord-312001-8p7scli8	305	26	to	to	TO
cord-312001-8p7scli8	305	27	block	block	VB
cord-312001-8p7scli8	305	28	murine	murine	JJ
cord-312001-8p7scli8	305	29	IFN	IFN	NNP
cord-312001-8p7scli8	305	30	-	-	HYPH
cord-312001-8p7scli8	305	31	β	β	NNP
cord-312001-8p7scli8	305	32	production	production	NN
cord-312001-8p7scli8	305	33	.	.	.
cord-312001-8p7scli8	306	1	Therefore	therefore	RB
cord-312001-8p7scli8	306	2	,	,	,
cord-312001-8p7scli8	306	3	it	-PRON-	PRP
cord-312001-8p7scli8	306	4	has	have	VBZ
cord-312001-8p7scli8	306	5	been	be	VBN
cord-312001-8p7scli8	306	6	proposed	propose	VBN
cord-312001-8p7scli8	306	7	that	that	IN
cord-312001-8p7scli8	306	8	the	the	DT
cord-312001-8p7scli8	306	9	inability	inability	NN
cord-312001-8p7scli8	306	10	of	of	IN
cord-312001-8p7scli8	306	11	DENV	DENV	NNP
cord-312001-8p7scli8	306	12	to	to	TO
cord-312001-8p7scli8	306	13	cleave	cleave	VB
cord-312001-8p7scli8	306	14	mouse	mouse	NN
cord-312001-8p7scli8	306	15	STING	sting	NN
cord-312001-8p7scli8	306	16	might	may	MD
cord-312001-8p7scli8	306	17	explain	explain	VB
cord-312001-8p7scli8	306	18	its	-PRON-	PRP$
cord-312001-8p7scli8	306	19	host	host	NN
cord-312001-8p7scli8	306	20	tropism	tropism	NN
cord-312001-8p7scli8	306	21	,	,	,
cord-312001-8p7scli8	306	22	as	as	IN
cord-312001-8p7scli8	306	23	murine	murine	JJ
cord-312001-8p7scli8	306	24	cells	cell	NNS
cord-312001-8p7scli8	306	25	are	be	VBP
cord-312001-8p7scli8	306	26	not	not	RB
cord-312001-8p7scli8	306	27	very	very	RB
cord-312001-8p7scli8	306	28	susceptible	susceptible	JJ
cord-312001-8p7scli8	306	29	to	to	IN
cord-312001-8p7scli8	306	30	DENV	DENV	NNP
cord-312001-8p7scli8	306	31	infection	infection	NN
cord-312001-8p7scli8	306	32	[	[	-LRB-
cord-312001-8p7scli8	306	33	212	212	CD
cord-312001-8p7scli8	306	34	,	,	,
cord-312001-8p7scli8	306	35	213	213	CD
cord-312001-8p7scli8	306	36	]	]	-RRB-
cord-312001-8p7scli8	306	37	.	.	.
cord-312001-8p7scli8	307	1	In	in	IN
cord-312001-8p7scli8	307	2	animals	animal	NNS
cord-312001-8p7scli8	307	3	,	,	,
cord-312001-8p7scli8	307	4	PRRs	prr	NNS
cord-312001-8p7scli8	307	5	and	and	CC
cord-312001-8p7scli8	307	6	their	-PRON-	PRP$
cord-312001-8p7scli8	307	7	associated	associate	VBN
cord-312001-8p7scli8	307	8	signaling	signal	VBG
cord-312001-8p7scli8	307	9	pathways	pathway	NNS
cord-312001-8p7scli8	307	10	are	be	VBP
cord-312001-8p7scli8	307	11	early	early	JJ
cord-312001-8p7scli8	307	12	and	and	CC
cord-312001-8p7scli8	307	13	potent	potent	JJ
cord-312001-8p7scli8	307	14	cellular	cellular	JJ
cord-312001-8p7scli8	307	15	sensors	sensor	NNS
cord-312001-8p7scli8	307	16	of	of	IN
cord-312001-8p7scli8	307	17	viral	viral	JJ
cord-312001-8p7scli8	307	18	elements	element	NNS
cord-312001-8p7scli8	307	19	,	,	,
cord-312001-8p7scli8	307	20	that	that	WDT
cord-312001-8p7scli8	307	21	mobilize	mobilize	VBP
cord-312001-8p7scli8	307	22	the	the	DT
cord-312001-8p7scli8	307	23	organism	organism	NN
cord-312001-8p7scli8	307	24	's	's	POS
cord-312001-8p7scli8	307	25	defenses	defense	NNS
cord-312001-8p7scli8	307	26	by	by	IN
cord-312001-8p7scli8	307	27	inducing	induce	VBG
cord-312001-8p7scli8	307	28	an	an	DT
cord-312001-8p7scli8	307	29	antiviral	antiviral	JJ
cord-312001-8p7scli8	307	30	state	state	NN
cord-312001-8p7scli8	307	31	.	.	.
cord-312001-8p7scli8	308	1	Major	major	JJ
cord-312001-8p7scli8	308	2	advances	advance	NNS
cord-312001-8p7scli8	308	3	have	have	VBP
cord-312001-8p7scli8	308	4	been	be	VBN
cord-312001-8p7scli8	308	5	made	make	VBN
cord-312001-8p7scli8	308	6	in	in	IN
cord-312001-8p7scli8	308	7	the	the	DT
cord-312001-8p7scli8	308	8	last	last	JJ
cord-312001-8p7scli8	308	9	two	two	CD
cord-312001-8p7scli8	308	10	decades	decade	NNS
cord-312001-8p7scli8	308	11	in	in	IN
cord-312001-8p7scli8	308	12	the	the	DT
cord-312001-8p7scli8	308	13	understanding	understanding	NN
cord-312001-8p7scli8	308	14	of	of	IN
cord-312001-8p7scli8	308	15	their	-PRON-	PRP$
cord-312001-8p7scli8	308	16	function	function	NN
cord-312001-8p7scli8	308	17	in	in	IN
cord-312001-8p7scli8	308	18	mammalian	mammalian	JJ
cord-312001-8p7scli8	308	19	immunity	immunity	NN
cord-312001-8p7scli8	308	20	.	.	.
cord-312001-8p7scli8	309	1	New	new	JJ
cord-312001-8p7scli8	309	2	genomics	genomic	NNS
cord-312001-8p7scli8	309	3	data	datum	NNS
cord-312001-8p7scli8	309	4	and	and	CC
cord-312001-8p7scli8	309	5	gene	gene	NN
cord-312001-8p7scli8	309	6	editing	editing	NN
cord-312001-8p7scli8	309	7	tools	tool	NNS
cord-312001-8p7scli8	309	8	can	can	MD
cord-312001-8p7scli8	309	9	now	now	RB
cord-312001-8p7scli8	309	10	let	let	VB
cord-312001-8p7scli8	309	11	us	-PRON-	PRP
cord-312001-8p7scli8	309	12	interrogate	interrogate	VB
cord-312001-8p7scli8	309	13	PRR	PRR	NNP
cord-312001-8p7scli8	309	14	-	-	HYPH
cord-312001-8p7scli8	309	15	like	like	JJ
cord-312001-8p7scli8	309	16	pathways	pathway	NNS
cord-312001-8p7scli8	309	17	in	in	IN
cord-312001-8p7scli8	309	18	poorly	poorly	RB
cord-312001-8p7scli8	309	19	studied	study	VBN
cord-312001-8p7scli8	309	20	animal	animal	NN
cord-312001-8p7scli8	309	21	species	specie	NNS
cord-312001-8p7scli8	309	22	and	and	CC
cord-312001-8p7scli8	309	23	define	define	VB
cord-312001-8p7scli8	309	24	their	-PRON-	PRP$
cord-312001-8p7scli8	309	25	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	309	26	trajectories	trajectory	NNS
cord-312001-8p7scli8	309	27	.	.	.
cord-312001-8p7scli8	310	1	Studying	study	VBG
cord-312001-8p7scli8	310	2	the	the	DT
cord-312001-8p7scli8	310	3	evolution	evolution	NN
cord-312001-8p7scli8	310	4	of	of	IN
cord-312001-8p7scli8	310	5	immune	immune	JJ
cord-312001-8p7scli8	310	6	components	component	NNS
cord-312001-8p7scli8	310	7	and	and	CC
cord-312001-8p7scli8	310	8	their	-PRON-	PRP$
cord-312001-8p7scli8	310	9	interplay	interplay	NN
cord-312001-8p7scli8	310	10	with	with	IN
cord-312001-8p7scli8	310	11	viral	viral	JJ
cord-312001-8p7scli8	310	12	pathogens	pathogen	NNS
cord-312001-8p7scli8	310	13	is	be	VBZ
cord-312001-8p7scli8	310	14	extremely	extremely	RB
cord-312001-8p7scli8	310	15	important	important	JJ
cord-312001-8p7scli8	310	16	since	since	IN
cord-312001-8p7scli8	310	17	our	-PRON-	PRP$
cord-312001-8p7scli8	310	18	immune	immune	JJ
cord-312001-8p7scli8	310	19	responses	response	NNS
cord-312001-8p7scli8	310	20	to	to	IN
cord-312001-8p7scli8	310	21	contemporary	contemporary	JJ
cord-312001-8p7scli8	310	22	viruses	virus	NNS
cord-312001-8p7scli8	310	23	have	have	VBP
cord-312001-8p7scli8	310	24	been	be	VBN
cord-312001-8p7scli8	310	25	shaped	shape	VBN
cord-312001-8p7scli8	310	26	by	by	IN
cord-312001-8p7scli8	310	27	our	-PRON-	PRP$
cord-312001-8p7scli8	310	28	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	310	29	responses	response	NNS
cord-312001-8p7scli8	310	30	to	to	IN
cord-312001-8p7scli8	310	31	previous	previous	JJ
cord-312001-8p7scli8	310	32	infections	infection	NNS
cord-312001-8p7scli8	310	33	.	.	.
cord-312001-8p7scli8	311	1	The	the	DT
cord-312001-8p7scli8	311	2	modern	modern	JJ
cord-312001-8p7scli8	311	3	innate	innate	JJ
cord-312001-8p7scli8	311	4	immune	immune	JJ
cord-312001-8p7scli8	311	5	system	system	NN
cord-312001-8p7scli8	311	6	is	be	VBZ
cord-312001-8p7scli8	311	7	generally	generally	RB
cord-312001-8p7scli8	311	8	not	not	RB
cord-312001-8p7scli8	311	9	yet	yet	RB
cord-312001-8p7scli8	311	10	optimized	optimize	VBN
cord-312001-8p7scli8	311	11	against	against	IN
cord-312001-8p7scli8	311	12	modern	modern	JJ
cord-312001-8p7scli8	311	13	viruses	virus	NNS
cord-312001-8p7scli8	311	14	but	but	CC
cord-312001-8p7scli8	311	15	rather	rather	RB
cord-312001-8p7scli8	311	16	was	be	VBD
cord-312001-8p7scli8	311	17	selected	select	VBN
cord-312001-8p7scli8	311	18	for	for	IN
cord-312001-8p7scli8	311	19	by	by	IN
cord-312001-8p7scli8	311	20	previous	previous	JJ
cord-312001-8p7scli8	311	21	rounds	round	NNS
cord-312001-8p7scli8	311	22	of	of	IN
cord-312001-8p7scli8	311	23	co	co	NN
cord-312001-8p7scli8	311	24	-	-	NN
cord-312001-8p7scli8	311	25	evolution	evolution	NN
cord-312001-8p7scli8	311	26	with	with	IN
cord-312001-8p7scli8	311	27	ancient	ancient	JJ
cord-312001-8p7scli8	311	28	viruses	virus	NNS
cord-312001-8p7scli8	311	29	[	[	-LRB-
cord-312001-8p7scli8	311	30	214	214	CD
cord-312001-8p7scli8	311	31	]	]	-RRB-
cord-312001-8p7scli8	311	32	.	.	.
cord-312001-8p7scli8	312	1	Studying	study	VBG
cord-312001-8p7scli8	312	2	the	the	DT
cord-312001-8p7scli8	312	3	biological	biological	JJ
cord-312001-8p7scli8	312	4	arms	arm	NNS
cord-312001-8p7scli8	312	5	race	race	NN
cord-312001-8p7scli8	312	6	between	between	IN
cord-312001-8p7scli8	312	7	host	host	NN
cord-312001-8p7scli8	312	8	and	and	CC
cord-312001-8p7scli8	312	9	virus	virus	NN
cord-312001-8p7scli8	312	10	,	,	,
cord-312001-8p7scli8	312	11	referred	refer	VBD
cord-312001-8p7scli8	312	12	to	to	IN
cord-312001-8p7scli8	312	13	as	as	IN
cord-312001-8p7scli8	312	14	the	the	DT
cord-312001-8p7scli8	312	15	"	"	``
cord-312001-8p7scli8	312	16	Red	Red	NNP
cord-312001-8p7scli8	312	17	Queen	Queen	NNP
cord-312001-8p7scli8	312	18	hypothesis	hypothesis	NN
cord-312001-8p7scli8	312	19	"	"	''
cord-312001-8p7scli8	312	20	[	[	-LRB-
cord-312001-8p7scli8	312	21	215	215	CD
cord-312001-8p7scli8	312	22	]	]	-RRB-
cord-312001-8p7scli8	312	23	,	,	,
cord-312001-8p7scli8	312	24	in	in	IN
cord-312001-8p7scli8	312	25	which	which	WDT
cord-312001-8p7scli8	312	26	each	each	DT
cord-312001-8p7scli8	312	27	entity	entity	NN
cord-312001-8p7scli8	312	28	maintains	maintain	VBZ
cord-312001-8p7scli8	312	29	a	a	DT
cord-312001-8p7scli8	312	30	relatively	relatively	RB
cord-312001-8p7scli8	312	31	constant	constant	JJ
cord-312001-8p7scli8	312	32	fitness	fitness	NN
cord-312001-8p7scli8	312	33	cost	cost	NN
cord-312001-8p7scli8	312	34	,	,	,
cord-312001-8p7scli8	312	35	will	will	MD
cord-312001-8p7scli8	312	36	be	be	VB
cord-312001-8p7scli8	312	37	instrumental	instrumental	JJ
cord-312001-8p7scli8	312	38	in	in	IN
cord-312001-8p7scli8	312	39	the	the	DT
cord-312001-8p7scli8	312	40	fight	fight	NN
cord-312001-8p7scli8	312	41	against	against	IN
cord-312001-8p7scli8	312	42	future	future	JJ
cord-312001-8p7scli8	312	43	infections	infection	NNS
cord-312001-8p7scli8	312	44	.	.	.
cord-312001-8p7scli8	313	1	Such	such	JJ
cord-312001-8p7scli8	313	2	studies	study	NNS
cord-312001-8p7scli8	313	3	will	will	MD
cord-312001-8p7scli8	313	4	help	help	VB
cord-312001-8p7scli8	313	5	us	-PRON-	PRP
cord-312001-8p7scli8	313	6	understand	understand	VB
cord-312001-8p7scli8	313	7	many	many	JJ
cord-312001-8p7scli8	313	8	aspects	aspect	NNS
cord-312001-8p7scli8	313	9	of	of	IN
cord-312001-8p7scli8	313	10	viral	viral	JJ
cord-312001-8p7scli8	313	11	infections	infection	NNS
cord-312001-8p7scli8	313	12	including	include	VBG
cord-312001-8p7scli8	313	13	viral	viral	JJ
cord-312001-8p7scli8	313	14	zoonoses	zoonosis	NNS
cord-312001-8p7scli8	313	15	,	,	,
cord-312001-8p7scli8	313	16	tropism	tropism	NN
cord-312001-8p7scli8	313	17	,	,	,
cord-312001-8p7scli8	313	18	global	global	JJ
cord-312001-8p7scli8	313	19	epidemics	epidemic	NNS
cord-312001-8p7scli8	313	20	and	and	CC
cord-312001-8p7scli8	313	21	disease	disease	NN
cord-312001-8p7scli8	313	22	progression	progression	NN
cord-312001-8p7scli8	313	23	.	.	.
cord-312001-8p7scli8	314	1	Furthermore	furthermore	RB
cord-312001-8p7scli8	314	2	,	,	,
cord-312001-8p7scli8	314	3	exploring	explore	VBG
cord-312001-8p7scli8	314	4	these	these	DT
cord-312001-8p7scli8	314	5	pathways	pathway	NNS
cord-312001-8p7scli8	314	6	and	and	CC
cord-312001-8p7scli8	314	7	mechanisms	mechanism	NNS
cord-312001-8p7scli8	314	8	for	for	IN
cord-312001-8p7scli8	314	9	therapeutic	therapeutic	JJ
cord-312001-8p7scli8	314	10	purposes	purpose	NNS
cord-312001-8p7scli8	314	11	may	may	MD
cord-312001-8p7scli8	314	12	offer	offer	VB
cord-312001-8p7scli8	314	13	novel	novel	JJ
cord-312001-8p7scli8	314	14	strategies	strategy	NNS
cord-312001-8p7scli8	314	15	to	to	TO
cord-312001-8p7scli8	314	16	cure	cure	VB
cord-312001-8p7scli8	314	17	human	human	JJ
cord-312001-8p7scli8	314	18	disease	disease	NN
cord-312001-8p7scli8	314	19	.	.	.
cord-312001-8p7scli8	315	1	Indeed	indeed	RB
cord-312001-8p7scli8	315	2	,	,	,
cord-312001-8p7scli8	315	3	modulating	modulate	VBG
cord-312001-8p7scli8	315	4	the	the	DT
cord-312001-8p7scli8	315	5	action	action	NN
cord-312001-8p7scli8	315	6	of	of	IN
cord-312001-8p7scli8	315	7	the	the	DT
cord-312001-8p7scli8	315	8	aforementioned	aforementioned	JJ
cord-312001-8p7scli8	315	9	immune	immune	JJ
cord-312001-8p7scli8	315	10	sensors	sensor	NNS
cord-312001-8p7scli8	315	11	is	be	VBZ
cord-312001-8p7scli8	315	12	proving	prove	VBG
cord-312001-8p7scli8	315	13	to	to	TO
cord-312001-8p7scli8	315	14	be	be	VB
cord-312001-8p7scli8	315	15	an	an	DT
cord-312001-8p7scli8	315	16	effective	effective	JJ
cord-312001-8p7scli8	315	17	strategy	strategy	NN
cord-312001-8p7scli8	315	18	to	to	TO
cord-312001-8p7scli8	315	19	develop	develop	VB
cord-312001-8p7scli8	315	20	vaccines	vaccine	NNS
cord-312001-8p7scli8	315	21	and	and	CC
cord-312001-8p7scli8	315	22	vaccine	vaccine	NN
cord-312001-8p7scli8	315	23	adjuvants	adjuvant	NNS
cord-312001-8p7scli8	315	24	[	[	-LRB-
cord-312001-8p7scli8	315	25	216	216	CD
cord-312001-8p7scli8	315	26	]	]	-RRB-
cord-312001-8p7scli8	315	27	[	[	-LRB-
cord-312001-8p7scli8	315	28	217	217	CD
cord-312001-8p7scli8	315	29	]	]	-RRB-
cord-312001-8p7scli8	315	30	[	[	-LRB-
cord-312001-8p7scli8	315	31	218	218	CD
cord-312001-8p7scli8	315	32	]	]	-RRB-
cord-312001-8p7scli8	315	33	[	[	-LRB-
cord-312001-8p7scli8	315	34	219	219	CD
cord-312001-8p7scli8	315	35	]	]	-RRB-
cord-312001-8p7scli8	315	36	[	[	-LRB-
cord-312001-8p7scli8	315	37	220	220	CD
cord-312001-8p7scli8	315	38	]	]	-RRB-
cord-312001-8p7scli8	315	39	or	or	CC
cord-312001-8p7scli8	315	40	to	to	TO
cord-312001-8p7scli8	315	41	treat	treat	VB
cord-312001-8p7scli8	315	42	viral	viral	JJ
cord-312001-8p7scli8	315	43	infections	infection	NNS
cord-312001-8p7scli8	315	44	[	[	-LRB-
cord-312001-8p7scli8	315	45	221	221	CD
cord-312001-8p7scli8	315	46	]	]	-RRB-
cord-312001-8p7scli8	315	47	[	[	-LRB-
cord-312001-8p7scli8	315	48	222	222	CD
cord-312001-8p7scli8	315	49	]	]	-RRB-
cord-312001-8p7scli8	315	50	[	[	-LRB-
cord-312001-8p7scli8	315	51	223	223	CD
cord-312001-8p7scli8	315	52	]	]	-RRB-
cord-312001-8p7scli8	315	53	[	[	-LRB-
cord-312001-8p7scli8	315	54	224	224	CD
cord-312001-8p7scli8	315	55	]	]	-RRB-
cord-312001-8p7scli8	315	56	[	[	-LRB-
cord-312001-8p7scli8	315	57	225	225	CD
cord-312001-8p7scli8	315	58	]	]	-RRB-
cord-312001-8p7scli8	315	59	[	[	-LRB-
cord-312001-8p7scli8	315	60	226	226	CD
cord-312001-8p7scli8	315	61	]	]	-RRB-
cord-312001-8p7scli8	315	62	.	.	.
cord-312001-8p7scli8	316	1	Finally	finally	RB
cord-312001-8p7scli8	316	2	,	,	,
cord-312001-8p7scli8	316	3	the	the	DT
cord-312001-8p7scli8	316	4	use	use	NN
cord-312001-8p7scli8	316	5	of	of	IN
cord-312001-8p7scli8	316	6	TLR	TLR	NNP
cord-312001-8p7scli8	316	7	,	,	,
cord-312001-8p7scli8	316	8	RLR	RLR	NNP
cord-312001-8p7scli8	316	9	and	and	CC
cord-312001-8p7scli8	316	10	STING	sting	NN
cord-312001-8p7scli8	316	11	modulators	modulator	NNS
cord-312001-8p7scli8	316	12	,	,	,
cord-312001-8p7scli8	316	13	to	to	TO
cord-312001-8p7scli8	316	14	treat	treat	VB
cord-312001-8p7scli8	316	15	inflammation	inflammation	NN
cord-312001-8p7scli8	316	16	,	,	,
cord-312001-8p7scli8	316	17	auto	auto	NN
cord-312001-8p7scli8	316	18	-	-	HYPH
cord-312001-8p7scli8	316	19	immune	immune	JJ
cord-312001-8p7scli8	316	20	disease	disease	NN
cord-312001-8p7scli8	316	21	[	[	-LRB-
cord-312001-8p7scli8	316	22	227	227	CD
cord-312001-8p7scli8	316	23	,	,	,
cord-312001-8p7scli8	316	24	228	228	CD
cord-312001-8p7scli8	316	25	]	]	-RRB-
cord-312001-8p7scli8	316	26	and	and	CC
cord-312001-8p7scli8	316	27	also	also	RB
cord-312001-8p7scli8	316	28	in	in	IN
cord-312001-8p7scli8	316	29	cancer	cancer	NN
cord-312001-8p7scli8	316	30	immunotherapy	immunotherapy	NN
cord-312001-8p7scli8	316	31	[	[	-LRB-
cord-312001-8p7scli8	316	32	229	229	CD
cord-312001-8p7scli8	316	33	]	]	-RRB-
cord-312001-8p7scli8	317	1	[	[	-LRB-
cord-312001-8p7scli8	317	2	230	230	CD
cord-312001-8p7scli8	317	3	]	]	-RRB-
cord-312001-8p7scli8	317	4	[	[	-LRB-
cord-312001-8p7scli8	317	5	231	231	CD
cord-312001-8p7scli8	317	6	]	]	-RRB-
cord-312001-8p7scli8	317	7	[	[	-LRB-
cord-312001-8p7scli8	317	8	232	232	CD
cord-312001-8p7scli8	317	9	]	]	-RRB-
cord-312001-8p7scli8	318	1	[	[	-LRB-
cord-312001-8p7scli8	318	2	233	233	CD
cord-312001-8p7scli8	318	3	]	]	-RRB-
cord-312001-8p7scli8	319	1	[	[	-LRB-
cord-312001-8p7scli8	319	2	234	234	CD
cord-312001-8p7scli8	319	3	]	]	-RRB-
cord-312001-8p7scli8	320	1	[	[	-LRB-
cord-312001-8p7scli8	320	2	235	235	CD
cord-312001-8p7scli8	320	3	]	]	-RRB-
cord-312001-8p7scli8	320	4	[	[	-LRB-
cord-312001-8p7scli8	320	5	236	236	CD
cord-312001-8p7scli8	320	6	]	]	-RRB-
cord-312001-8p7scli8	320	7	provides	provide	VBZ
cord-312001-8p7scli8	320	8	an	an	DT
cord-312001-8p7scli8	320	9	eloquent	eloquent	JJ
cord-312001-8p7scli8	320	10	incentive	incentive	NN
cord-312001-8p7scli8	320	11	to	to	TO
cord-312001-8p7scli8	320	12	continue	continue	VB
cord-312001-8p7scli8	320	13	studying	study	VBG
cord-312001-8p7scli8	320	14	these	these	DT
cord-312001-8p7scli8	320	15	pathways	pathway	NNS
cord-312001-8p7scli8	320	16	and	and	CC
cord-312001-8p7scli8	320	17	to	to	TO
cord-312001-8p7scli8	320	18	look	look	VB
cord-312001-8p7scli8	320	19	ahead	ahead	RB
cord-312001-8p7scli8	320	20	with	with	IN
cord-312001-8p7scli8	320	21	great	great	JJ
cord-312001-8p7scli8	320	22	optimism	optimism	NN
cord-312001-8p7scli8	320	23	.	.	.
cord-312001-8p7scli8	320	24	 	 	_SP
cord-312001-8p7scli8	321	1	A	a	DT
cord-312001-8p7scli8	321	2	virocentric	virocentric	JJ
cord-312001-8p7scli8	321	3	perspective	perspective	NN
cord-312001-8p7scli8	321	4	on	on	IN
cord-312001-8p7scli8	321	5	the	the	DT
cord-312001-8p7scli8	321	6	evolution	evolution	NN
cord-312001-8p7scli8	321	7	of	of	IN
cord-312001-8p7scli8	321	8	life	life	NN
cord-312001-8p7scli8	321	9	Evolution	evolution	NN
cord-312001-8p7scli8	321	10	of	of	IN
cord-312001-8p7scli8	321	11	innate	innate	JJ
cord-312001-8p7scli8	321	12	immunity	immunity	NN
cord-312001-8p7scli8	322	1	:	:	:
cord-312001-8p7scli8	322	2	Clues	clue	NNS
cord-312001-8p7scli8	322	3	from	from	IN
cord-312001-8p7scli8	322	4	invertebrates	invertebrate	NNS
cord-312001-8p7scli8	322	5	via	via	IN
cord-312001-8p7scli8	322	6	fish	fish	NN
cord-312001-8p7scli8	322	7	to	to	IN
cord-312001-8p7scli8	322	8	mammals	mammal	NNS
cord-312001-8p7scli8	322	9	Evolution	evolution	NN
cord-312001-8p7scli8	322	10	of	of	IN
cord-312001-8p7scli8	322	11	interferons	interferon	NNS
cord-312001-8p7scli8	322	12	and	and	CC
cord-312001-8p7scli8	322	13	interferon	interferon	NN
cord-312001-8p7scli8	322	14	receptors	receptor	NNS
cord-312001-8p7scli8	322	15	Transcriptional	Transcriptional	NNP
cord-312001-8p7scli8	322	16	regulation	regulation	NN
cord-312001-8p7scli8	322	17	of	of	IN
cord-312001-8p7scli8	322	18	antiviral	antiviral	JJ
cord-312001-8p7scli8	322	19	interferon	interferon	NN
cord-312001-8p7scli8	322	20	-	-	HYPH
cord-312001-8p7scli8	322	21	stimulated	stimulate	VBN
cord-312001-8p7scli8	322	22	genes	gene	NNS
cord-312001-8p7scli8	322	23	Antiviral	antiviral	JJ
cord-312001-8p7scli8	322	24	defense	defense	NN
cord-312001-8p7scli8	322	25	and	and	CC
cord-312001-8p7scli8	322	26	innate	innate	JJ
cord-312001-8p7scli8	322	27	immune	immune	JJ
cord-312001-8p7scli8	322	28	memory	memory	NN
cord-312001-8p7scli8	322	29	in	in	IN
cord-312001-8p7scli8	322	30	the	the	DT
cord-312001-8p7scli8	322	31	oyster	oyster	NN
cord-312001-8p7scli8	322	32	Dynamic	dynamic	JJ
cord-312001-8p7scli8	322	33	evolution	evolution	NN
cord-312001-8p7scli8	322	34	of	of	IN
cord-312001-8p7scli8	322	35	immune	immune	JJ
cord-312001-8p7scli8	322	36	system	system	NN
cord-312001-8p7scli8	322	37	regulators	regulator	NNS
cord-312001-8p7scli8	322	38	:	:	:
cord-312001-8p7scli8	323	1	The	the	DT
cord-312001-8p7scli8	323	2	history	history	NN
cord-312001-8p7scli8	323	3	of	of	IN
cord-312001-8p7scli8	323	4	the	the	DT
cord-312001-8p7scli8	323	5	interferon	interferon	NN
cord-312001-8p7scli8	323	6	regulatory	regulatory	JJ
cord-312001-8p7scli8	323	7	factor	factor	NN
cord-312001-8p7scli8	323	8	family	family	NN
cord-312001-8p7scli8	323	9	IFN	IFN	NNP
cord-312001-8p7scli8	323	10	regulatory	regulatory	JJ
cord-312001-8p7scli8	323	11	factor-1	factor-1	NNP
cord-312001-8p7scli8	323	12	bypasses	bypass	VBZ
cord-312001-8p7scli8	323	13	IFN	IFN	NNP
cord-312001-8p7scli8	323	14	-	-	HYPH
cord-312001-8p7scli8	323	15	mediated	mediate	VBN
cord-312001-8p7scli8	323	16	antiviral	antiviral	JJ
cord-312001-8p7scli8	323	17	effects	effect	NNS
cord-312001-8p7scli8	323	18	through	through	IN
cord-312001-8p7scli8	323	19	viperin	viperin	NNP
cord-312001-8p7scli8	323	20	gene	gene	NN
cord-312001-8p7scli8	323	21	induction	induction	NN
cord-312001-8p7scli8	323	22	Constitutive	constitutive	JJ
cord-312001-8p7scli8	323	23	expression	expression	NN
cord-312001-8p7scli8	323	24	of	of	IN
cord-312001-8p7scli8	323	25	an	an	DT
cord-312001-8p7scli8	323	26	ISGF2	ISGF2	NNP
cord-312001-8p7scli8	323	27	/	/	SYM
cord-312001-8p7scli8	323	28	IRF1	IRF1	NNP
cord-312001-8p7scli8	323	29	transgene	transgene	NN
cord-312001-8p7scli8	323	30	leads	lead	VBZ
cord-312001-8p7scli8	323	31	to	to	IN
cord-312001-8p7scli8	323	32	interferon	interferon	NN
cord-312001-8p7scli8	323	33	-	-	HYPH
cord-312001-8p7scli8	323	34	independent	independent	JJ
cord-312001-8p7scli8	323	35	activation	activation	NN
cord-312001-8p7scli8	323	36	of	of	IN
cord-312001-8p7scli8	323	37	interferon	interferon	NN
cord-312001-8p7scli8	323	38	-	-	HYPH
cord-312001-8p7scli8	323	39	inducible	inducible	JJ
cord-312001-8p7scli8	323	40	genes	gene	NNS
cord-312001-8p7scli8	323	41	and	and	CC
cord-312001-8p7scli8	323	42	resistance	resistance	NN
cord-312001-8p7scli8	323	43	to	to	IN
cord-312001-8p7scli8	323	44	virus	virus	NN
cord-312001-8p7scli8	323	45	infection	infection	NN
cord-312001-8p7scli8	323	46	Transcriptional	Transcriptional	NNP
cord-312001-8p7scli8	323	47	profiling	profiling	NN
cord-312001-8p7scli8	323	48	of	of	IN
cord-312001-8p7scli8	323	49	interferon	interferon	NN
cord-312001-8p7scli8	323	50	regulatory	regulatory	JJ
cord-312001-8p7scli8	323	51	factor	factor	NN
cord-312001-8p7scli8	323	52	3	3	CD
cord-312001-8p7scli8	323	53	target	target	NN
cord-312001-8p7scli8	323	54	genes	gene	NNS
cord-312001-8p7scli8	323	55	:	:	:
cord-312001-8p7scli8	324	1	Direct	direct	JJ
cord-312001-8p7scli8	324	2	involvement	involvement	NN
cord-312001-8p7scli8	324	3	in	in	IN
cord-312001-8p7scli8	324	4	the	the	DT
cord-312001-8p7scli8	324	5	regulation	regulation	NN
cord-312001-8p7scli8	324	6	of	of	IN
cord-312001-8p7scli8	324	7	interferon	interferon	NN
cord-312001-8p7scli8	324	8	-	-	HYPH
cord-312001-8p7scli8	324	9	stimulated	stimulate	VBN
cord-312001-8p7scli8	324	10	genes	gene	NNS
cord-312001-8p7scli8	324	11	Phylogenetic	Phylogenetic	NNP
cord-312001-8p7scli8	324	12	analysis	analysis	NN
cord-312001-8p7scli8	324	13	of	of	IN
cord-312001-8p7scli8	324	14	the	the	DT
cord-312001-8p7scli8	324	15	endoribonuclease	endoribonuclease	NNP
cord-312001-8p7scli8	324	16	Dicer	Dicer	NNP
cord-312001-8p7scli8	324	17	family	family	NN
cord-312001-8p7scli8	325	1	Early	early	JJ
cord-312001-8p7scli8	325	2	origins	origin	NNS
cord-312001-8p7scli8	325	3	and	and	CC
cord-312001-8p7scli8	325	4	evolution	evolution	NN
cord-312001-8p7scli8	325	5	of	of	IN
cord-312001-8p7scli8	325	6	microRNAs	microRNAs	NNPS
cord-312001-8p7scli8	325	7	and	and	CC
cord-312001-8p7scli8	325	8	Piwi	piwi	NN
cord-312001-8p7scli8	325	9	-	-	HYPH
cord-312001-8p7scli8	325	10	interacting	interact	VBG
cord-312001-8p7scli8	325	11	RNAs	rna	NNS
cord-312001-8p7scli8	325	12	in	in	IN
cord-312001-8p7scli8	325	13	animals	animal	NNS
cord-312001-8p7scli8	326	1	Molecular	molecular	JJ
cord-312001-8p7scli8	326	2	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	326	3	and	and	CC
cord-312001-8p7scli8	326	4	structural	structural	JJ
cord-312001-8p7scli8	326	5	analysis	analysis	NN
cord-312001-8p7scli8	326	6	of	of	IN
cord-312001-8p7scli8	326	7	the	the	DT
cord-312001-8p7scli8	326	8	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	326	9	DNA	dna	NN
cord-312001-8p7scli8	326	10	sensor	sensor	NN
cord-312001-8p7scli8	326	11	cGAS	cgas	NN
cord-312001-8p7scli8	326	12	and	and	CC
cord-312001-8p7scli8	326	13	STING	sting	VB
cord-312001-8p7scli8	326	14	Ancient	ancient	JJ
cord-312001-8p7scli8	326	15	origin	origin	NN
cord-312001-8p7scli8	326	16	of	of	IN
cord-312001-8p7scli8	326	17	cGAS	cgas	JJ
cord-312001-8p7scli8	326	18	-	-	HYPH
cord-312001-8p7scli8	326	19	STING	sting	NN
cord-312001-8p7scli8	326	20	reveals	reveal	VBZ
cord-312001-8p7scli8	326	21	mechanism	mechanism	NN
cord-312001-8p7scli8	326	22	of	of	IN
cord-312001-8p7scli8	326	23	universal	universal	JJ
cord-312001-8p7scli8	326	24	2	2	CD
cord-312001-8p7scli8	326	25	,	,	,
cord-312001-8p7scli8	326	26	3	3	CD
cord-312001-8p7scli8	326	27	cGAMP	cgamp	NN
cord-312001-8p7scli8	326	28	signaling	signal	VBG
cord-312001-8p7scli8	326	29	Ancient	ancient	JJ
cord-312001-8p7scli8	326	30	origins	origin	NNS
cord-312001-8p7scli8	326	31	of	of	IN
cord-312001-8p7scli8	326	32	vertebrate	vertebrate	NN
cord-312001-8p7scli8	326	33	-	-	HYPH
cord-312001-8p7scli8	326	34	specific	specific	JJ
cord-312001-8p7scli8	326	35	innate	innate	JJ
cord-312001-8p7scli8	326	36	antiviral	antiviral	JJ
cord-312001-8p7scli8	326	37	immunity	immunity	NN
cord-312001-8p7scli8	327	1	The	the	DT
cord-312001-8p7scli8	327	2	evolution	evolution	NN
cord-312001-8p7scli8	327	3	of	of	IN
cord-312001-8p7scli8	327	4	vertebrate	vertebrate	JJ
cord-312001-8p7scli8	327	5	Toll	toll	NN
cord-312001-8p7scli8	327	6	-	-	HYPH
cord-312001-8p7scli8	327	7	like	like	JJ
cord-312001-8p7scli8	327	8	receptors	receptor	NNS
cord-312001-8p7scli8	327	9	Evolution	evolution	NN
cord-312001-8p7scli8	327	10	of	of	IN
cord-312001-8p7scli8	327	11	MDA-5	MDA-5	NNP
cord-312001-8p7scli8	327	12	/	/	SYM
cord-312001-8p7scli8	327	13	RIG	rig	NN
cord-312001-8p7scli8	327	14	-	-	HYPH
cord-312001-8p7scli8	327	15	I	i	NN
cord-312001-8p7scli8	327	16	-	-	HYPH
cord-312001-8p7scli8	327	17	dependent	dependent	JJ
cord-312001-8p7scli8	327	18	innate	innate	JJ
cord-312001-8p7scli8	327	19	immunity	immunity	NN
cord-312001-8p7scli8	327	20	:	:	:
cord-312001-8p7scli8	327	21	Independent	independent	JJ
cord-312001-8p7scli8	327	22	evolution	evolution	NN
cord-312001-8p7scli8	327	23	by	by	IN
cord-312001-8p7scli8	327	24	domain	domain	NN
cord-312001-8p7scli8	327	25	grafting	graft	VBG
cord-312001-8p7scli8	327	26	NF	nf	NN
cord-312001-8p7scli8	327	27	-	-	HYPH
cord-312001-8p7scli8	327	28	kappaB	kappaB	NNP
cord-312001-8p7scli8	327	29	signaling	signal	VBG
cord-312001-8p7scli8	327	30	pathways	pathway	NNS
cord-312001-8p7scli8	327	31	in	in	IN
cord-312001-8p7scli8	327	32	mammalian	mammalian	JJ
cord-312001-8p7scli8	327	33	and	and	CC
cord-312001-8p7scli8	327	34	insect	insect	NN
cord-312001-8p7scli8	327	35	innate	innate	JJ
cord-312001-8p7scli8	327	36	immunity	immunity	NN
cord-312001-8p7scli8	328	1	The	the	DT
cord-312001-8p7scli8	328	2	evolution	evolution	NN
cord-312001-8p7scli8	328	3	of	of	IN
cord-312001-8p7scli8	328	4	antiviral	antiviral	JJ
cord-312001-8p7scli8	328	5	defense	defense	NN
cord-312001-8p7scli8	328	6	systems	system	NNS
cord-312001-8p7scli8	329	1	The	the	DT
cord-312001-8p7scli8	329	2	frustrated	frustrated	JJ
cord-312001-8p7scli8	329	3	gene	gene	NN
cord-312001-8p7scli8	329	4	:	:	:
cord-312001-8p7scli8	329	5	Origins	origin	NNS
cord-312001-8p7scli8	329	6	of	of	IN
cord-312001-8p7scli8	329	7	eukaryotic	eukaryotic	JJ
cord-312001-8p7scli8	329	8	gene	gene	NN
cord-312001-8p7scli8	329	9	expression	expression	NN
cord-312001-8p7scli8	329	10	Antiviral	antiviral	JJ
cord-312001-8p7scli8	329	11	immunity	immunity	NN
cord-312001-8p7scli8	329	12	directed	direct	VBN
cord-312001-8p7scli8	329	13	by	by	IN
cord-312001-8p7scli8	329	14	small	small	JJ
cord-312001-8p7scli8	329	15	RNAs	rna	NNS
cord-312001-8p7scli8	329	16	CRISPR	CRISPR	NNP
cord-312001-8p7scli8	329	17	-	-	HYPH
cord-312001-8p7scli8	329	18	Cas	Cas	NNP
cord-312001-8p7scli8	329	19	immunity	immunity	NN
cord-312001-8p7scli8	329	20	in	in	IN
cord-312001-8p7scli8	329	21	prokaryotes	prokaryote	NNS
cord-312001-8p7scli8	330	1	The	the	DT
cord-312001-8p7scli8	330	2	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	330	3	journey	journey	NN
cord-312001-8p7scli8	330	4	of	of	IN
cord-312001-8p7scli8	330	5	Argonaute	Argonaute	NNP
cord-312001-8p7scli8	330	6	proteins	protein	NNS
cord-312001-8p7scli8	330	7	On	on	IN
cord-312001-8p7scli8	330	8	the	the	DT
cord-312001-8p7scli8	330	9	origin	origin	NN
cord-312001-8p7scli8	330	10	and	and	CC
cord-312001-8p7scli8	330	11	functions	function	NNS
cord-312001-8p7scli8	330	12	of	of	IN
cord-312001-8p7scli8	330	13	RNA	rna	NN
cord-312001-8p7scli8	330	14	-	-	HYPH
cord-312001-8p7scli8	330	15	mediated	mediate	VBN
cord-312001-8p7scli8	330	16	silencing	silencing	NN
cord-312001-8p7scli8	330	17	:	:	:
cord-312001-8p7scli8	330	18	From	from	IN
cord-312001-8p7scli8	330	19	protists	protist	NNS
cord-312001-8p7scli8	330	20	to	to	TO
cord-312001-8p7scli8	330	21	man	man	VB
cord-312001-8p7scli8	330	22	RNA	RNA	NNP
cord-312001-8p7scli8	330	23	interference	interference	NN
cord-312001-8p7scli8	330	24	to	to	TO
cord-312001-8p7scli8	330	25	treat	treat	VB
cord-312001-8p7scli8	330	26	virus	virus	NN
cord-312001-8p7scli8	330	27	infections	infection	NNS
cord-312001-8p7scli8	330	28	Specific	specific	JJ
cord-312001-8p7scli8	330	29	interference	interference	NN
cord-312001-8p7scli8	330	30	with	with	IN
cord-312001-8p7scli8	330	31	gene	gene	NN
cord-312001-8p7scli8	330	32	expression	expression	NN
cord-312001-8p7scli8	330	33	induced	induce	VBN
cord-312001-8p7scli8	330	34	by	by	IN
cord-312001-8p7scli8	330	35	long	long	JJ
cord-312001-8p7scli8	330	36	,	,	,
cord-312001-8p7scli8	330	37	double	double	RB
cord-312001-8p7scli8	330	38	-	-	HYPH
cord-312001-8p7scli8	330	39	stranded	strand	VBN
cord-312001-8p7scli8	330	40	RNA	RNA	NNP
cord-312001-8p7scli8	330	41	in	in	IN
cord-312001-8p7scli8	330	42	mouse	mouse	NN
cord-312001-8p7scli8	330	43	embryonal	embryonal	NNP
cord-312001-8p7scli8	330	44	teratocarcinoma	teratocarcinoma	NNP
cord-312001-8p7scli8	330	45	cell	cell	NN
cord-312001-8p7scli8	330	46	lines	line	NNS
cord-312001-8p7scli8	330	47	Antiviral	Antiviral	NNP
cord-312001-8p7scli8	330	48	RNA	RNA	NNP
cord-312001-8p7scli8	330	49	interference	interference	NN
cord-312001-8p7scli8	330	50	in	in	IN
cord-312001-8p7scli8	330	51	mammalian	mammalian	JJ
cord-312001-8p7scli8	330	52	cells	cell	NNS
cord-312001-8p7scli8	330	53	Transposition	transposition	NN
cord-312001-8p7scli8	330	54	mediated	mediate	VBN
cord-312001-8p7scli8	330	55	by	by	IN
cord-312001-8p7scli8	330	56	RAG1	RAG1	NNP
cord-312001-8p7scli8	330	57	and	and	CC
cord-312001-8p7scli8	330	58	RAG2	RAG2	NNP
cord-312001-8p7scli8	330	59	and	and	CC
cord-312001-8p7scli8	330	60	its	-PRON-	PRP$
cord-312001-8p7scli8	330	61	implications	implication	NNS
cord-312001-8p7scli8	330	62	for	for	IN
cord-312001-8p7scli8	330	63	the	the	DT
cord-312001-8p7scli8	330	64	evolution	evolution	NN
cord-312001-8p7scli8	330	65	of	of	IN
cord-312001-8p7scli8	330	66	the	the	DT
cord-312001-8p7scli8	330	67	immune	immune	JJ
cord-312001-8p7scli8	330	68	system	system	NN
cord-312001-8p7scli8	330	69	Primordial	primordial	JJ
cord-312001-8p7scli8	330	70	emergence	emergence	NN
cord-312001-8p7scli8	330	71	of	of	IN
cord-312001-8p7scli8	330	72	the	the	DT
cord-312001-8p7scli8	330	73	recombination	recombination	NN
cord-312001-8p7scli8	330	74	activating	activate	VBG
cord-312001-8p7scli8	330	75	gene	gene	NN
cord-312001-8p7scli8	330	76	1	1	CD
cord-312001-8p7scli8	330	77	(	(	-LRB-
cord-312001-8p7scli8	330	78	RAG1	RAG1	NNP
cord-312001-8p7scli8	330	79	)	)	-RRB-
cord-312001-8p7scli8	330	80	:	:	:
cord-312001-8p7scli8	330	81	Sequence	sequence	NN
cord-312001-8p7scli8	330	82	of	of	IN
cord-312001-8p7scli8	330	83	the	the	DT
cord-312001-8p7scli8	330	84	complete	complete	JJ
cord-312001-8p7scli8	330	85	shark	shark	NN
cord-312001-8p7scli8	330	86	gene	gene	NN
cord-312001-8p7scli8	330	87	indicates	indicate	VBZ
cord-312001-8p7scli8	330	88	homology	homology	NN
cord-312001-8p7scli8	330	89	to	to	IN
cord-312001-8p7scli8	330	90	microbial	microbial	JJ
cord-312001-8p7scli8	330	91	integrases	integrase	NNS
cord-312001-8p7scli8	330	92	Evolution	Evolution	NNP
cord-312001-8p7scli8	330	93	of	of	IN
cord-312001-8p7scli8	330	94	immune	immune	JJ
cord-312001-8p7scli8	330	95	systems	system	NNS
cord-312001-8p7scli8	330	96	from	from	IN
cord-312001-8p7scli8	330	97	viruses	virus	NNS
cord-312001-8p7scli8	330	98	and	and	CC
cord-312001-8p7scli8	330	99	transposable	transposable	JJ
cord-312001-8p7scli8	330	100	elements	element	NNS
cord-312001-8p7scli8	331	1	Re	re	NN
cord-312001-8p7scli8	331	2	-	-	NN
cord-312001-8p7scli8	331	3	evaluation	evaluation	NN
cord-312001-8p7scli8	331	4	of	of	IN
cord-312001-8p7scli8	331	5	the	the	DT
cord-312001-8p7scli8	331	6	immunological	immunological	JJ
cord-312001-8p7scli8	331	7	Big	Big	NNP
cord-312001-8p7scli8	331	8	Bang	Bang	NNP
cord-312001-8p7scli8	331	9	Pattern	Pattern	NNP
cord-312001-8p7scli8	331	10	recognition	recognition	NN
cord-312001-8p7scli8	331	11	receptors	receptor	NNS
cord-312001-8p7scli8	331	12	and	and	CC
cord-312001-8p7scli8	331	13	control	control	NN
cord-312001-8p7scli8	331	14	of	of	IN
cord-312001-8p7scli8	331	15	adaptive	adaptive	JJ
cord-312001-8p7scli8	331	16	immunity	immunity	NN
cord-312001-8p7scli8	331	17	Approaching	approach	VBG
cord-312001-8p7scli8	331	18	the	the	DT
cord-312001-8p7scli8	331	19	asymptote	asymptote	NN
cord-312001-8p7scli8	331	20	?	?	.
cord-312001-8p7scli8	332	1	Evolution	evolution	NN
cord-312001-8p7scli8	332	2	and	and	CC
cord-312001-8p7scli8	332	3	revolution	revolution	NN
cord-312001-8p7scli8	332	4	in	in	IN
cord-312001-8p7scli8	332	5	immunology	immunology	NN
cord-312001-8p7scli8	332	6	Crosstalk	crosstalk	NN
cord-312001-8p7scli8	332	7	between	between	IN
cord-312001-8p7scli8	332	8	cytoplasmic	cytoplasmic	JJ
cord-312001-8p7scli8	332	9	RIG	rig	NN
cord-312001-8p7scli8	332	10	-	-	:
cord-312001-8p7scli8	332	11	I	-PRON-	PRP
cord-312001-8p7scli8	332	12	and	and	CC
cord-312001-8p7scli8	332	13	STING	sting	VB
cord-312001-8p7scli8	332	14	sensing	sense	VBG
cord-312001-8p7scli8	332	15	pathways	pathway	NNS
cord-312001-8p7scli8	332	16	Discriminating	discriminate	VBG
cord-312001-8p7scli8	332	17	self	self	NN
cord-312001-8p7scli8	332	18	from	from	IN
cord-312001-8p7scli8	332	19	non	non	JJ
cord-312001-8p7scli8	332	20	-	-	JJ
cord-312001-8p7scli8	332	21	self	self	JJ
cord-312001-8p7scli8	332	22	in	in	IN
cord-312001-8p7scli8	332	23	nucleic	nucleic	JJ
cord-312001-8p7scli8	332	24	acid	acid	NN
cord-312001-8p7scli8	332	25	sensing	sensing	NN
cord-312001-8p7scli8	332	26	Innate	innate	JJ
cord-312001-8p7scli8	332	27	immune	immune	JJ
cord-312001-8p7scli8	332	28	pattern	pattern	NN
cord-312001-8p7scli8	332	29	recognition	recognition	NN
cord-312001-8p7scli8	333	1	:	:	:
cord-312001-8p7scli8	333	2	A	a	DT
cord-312001-8p7scli8	333	3	cell	cell	NN
cord-312001-8p7scli8	333	4	biological	biological	NN
cord-312001-8p7scli8	333	5	perspective	perspective	NN
cord-312001-8p7scli8	333	6	Recognition	Recognition	NNP
cord-312001-8p7scli8	333	7	of	of	IN
cord-312001-8p7scli8	333	8	double	double	RB
cord-312001-8p7scli8	333	9	-	-	HYPH
cord-312001-8p7scli8	333	10	stranded	strand	VBN
cord-312001-8p7scli8	333	11	RNA	RNA	NNP
cord-312001-8p7scli8	333	12	and	and	CC
cord-312001-8p7scli8	333	13	activation	activation	NN
cord-312001-8p7scli8	333	14	of	of	IN
cord-312001-8p7scli8	333	15	NF	NF	NNP
cord-312001-8p7scli8	333	16	-	-	HYPH
cord-312001-8p7scli8	333	17	kappaB	kappaB	NNP
cord-312001-8p7scli8	333	18	by	by	IN
cord-312001-8p7scli8	333	19	Toll	Toll	NNP
cord-312001-8p7scli8	333	20	-	-	HYPH
cord-312001-8p7scli8	333	21	like	like	JJ
cord-312001-8p7scli8	333	22	receptor	receptor	NN
cord-312001-8p7scli8	333	23	3	3	CD
cord-312001-8p7scli8	333	24	Recognition	recognition	NN
cord-312001-8p7scli8	333	25	of	of	IN
cord-312001-8p7scli8	333	26	single	single	RB
cord-312001-8p7scli8	333	27	-	-	HYPH
cord-312001-8p7scli8	333	28	stranded	strand	VBN
cord-312001-8p7scli8	333	29	RNA	RNA	NNP
cord-312001-8p7scli8	333	30	viruses	virus	NNS
cord-312001-8p7scli8	333	31	by	by	IN
cord-312001-8p7scli8	333	32	Toll	toll	NN
cord-312001-8p7scli8	333	33	-	-	HYPH
cord-312001-8p7scli8	333	34	like	like	JJ
cord-312001-8p7scli8	333	35	receptor	receptor	NN
cord-312001-8p7scli8	333	36	7	7	CD
cord-312001-8p7scli8	333	37	Human	Human	NNP
cord-312001-8p7scli8	333	38	TLR-7-	TLR-7-	NNP
cord-312001-8p7scli8	333	39	,	,	,
cord-312001-8p7scli8	333	40	-8-	-8-	:
cord-312001-8p7scli8	333	41	,	,	,
cord-312001-8p7scli8	333	42	and	and	CC
cord-312001-8p7scli8	333	43	-9-mediated	-9-mediated	JJ
cord-312001-8p7scli8	333	44	induction	induction	NN
cord-312001-8p7scli8	333	45	of	of	IN
cord-312001-8p7scli8	333	46	IFN	IFN	NNP
cord-312001-8p7scli8	333	47	-	-	HYPH
cord-312001-8p7scli8	333	48	alpha	alpha	NN
cord-312001-8p7scli8	333	49	/	/	SYM
cord-312001-8p7scli8	333	50	beta	beta	NN
cord-312001-8p7scli8	333	51	and	and	CC
cord-312001-8p7scli8	333	52	-lambda	-lambda	NN
cord-312001-8p7scli8	333	53	Is	be	VBZ
cord-312001-8p7scli8	333	54	IRAK-4	irak-4	NN
cord-312001-8p7scli8	333	55	dependent	dependent	JJ
cord-312001-8p7scli8	333	56	and	and	CC
cord-312001-8p7scli8	333	57	redundant	redundant	JJ
cord-312001-8p7scli8	333	58	for	for	IN
cord-312001-8p7scli8	333	59	protective	protective	JJ
cord-312001-8p7scli8	333	60	immunity	immunity	NN
cord-312001-8p7scli8	333	61	to	to	IN
cord-312001-8p7scli8	333	62	viruses	virus	NNS
cord-312001-8p7scli8	334	1	The	the	DT
cord-312001-8p7scli8	334	2	RNA	RNA	NNP
cord-312001-8p7scli8	334	3	helicase	helicase	NN
cord-312001-8p7scli8	334	4	RIG	rig	NN
cord-312001-8p7scli8	334	5	-	-	:
cord-312001-8p7scli8	334	6	I	-PRON-	PRP
cord-312001-8p7scli8	334	7	has	have	VBZ
cord-312001-8p7scli8	334	8	an	an	DT
cord-312001-8p7scli8	334	9	essential	essential	JJ
cord-312001-8p7scli8	334	10	function	function	NN
cord-312001-8p7scli8	334	11	in	in	IN
cord-312001-8p7scli8	334	12	double	double	RB
cord-312001-8p7scli8	334	13	-	-	HYPH
cord-312001-8p7scli8	334	14	stranded	strand	VBN
cord-312001-8p7scli8	334	15	RNA	rna	NN
cord-312001-8p7scli8	334	16	-	-	HYPH
cord-312001-8p7scli8	334	17	induced	induce	VBN
cord-312001-8p7scli8	334	18	innate	innate	JJ
cord-312001-8p7scli8	334	19	antiviral	antiviral	JJ
cord-312001-8p7scli8	334	20	responses	response	NNS
cord-312001-8p7scli8	335	1	Inhibition	inhibition	NN
cord-312001-8p7scli8	335	2	of	of	IN
cord-312001-8p7scli8	335	3	the	the	DT
cord-312001-8p7scli8	335	4	RNA	RNA	NNP
cord-312001-8p7scli8	335	5	polymerase	polymerase	NN
cord-312001-8p7scli8	335	6	III	III	NNP
cord-312001-8p7scli8	335	7	-	-	HYPH
cord-312001-8p7scli8	335	8	mediated	mediate	VBN
cord-312001-8p7scli8	335	9	dsDNA	dsdna	RB
cord-312001-8p7scli8	335	10	-	-	HYPH
cord-312001-8p7scli8	335	11	sensing	sense	VBG
cord-312001-8p7scli8	335	12	pathway	pathway	NN
cord-312001-8p7scli8	335	13	of	of	IN
cord-312001-8p7scli8	335	14	innate	innate	JJ
cord-312001-8p7scli8	335	15	immunity	immunity	NN
cord-312001-8p7scli8	335	16	by	by	IN
cord-312001-8p7scli8	335	17	vaccinia	vaccinia	NN
cord-312001-8p7scli8	335	18	virus	virus	NN
cord-312001-8p7scli8	335	19	protein	protein	NN
cord-312001-8p7scli8	335	20	E3	E3	NNP
cord-312001-8p7scli8	335	21	RNA	RNA	NNP
cord-312001-8p7scli8	335	22	polymerase	polymerase	NN
cord-312001-8p7scli8	335	23	III	III	NNP
cord-312001-8p7scli8	335	24	detects	detect	VBZ
cord-312001-8p7scli8	335	25	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	335	26	DNA	dna	NN
cord-312001-8p7scli8	335	27	and	and	CC
cord-312001-8p7scli8	335	28	induces	induce	VBZ
cord-312001-8p7scli8	335	29	type	type	NN
cord-312001-8p7scli8	335	30	I	-PRON-	PRP
cord-312001-8p7scli8	335	31	interferons	interferon	NNS
cord-312001-8p7scli8	335	32	through	through	IN
cord-312001-8p7scli8	335	33	the	the	DT
cord-312001-8p7scli8	335	34	RIG	rig	NN
cord-312001-8p7scli8	335	35	-	-	:
cord-312001-8p7scli8	335	36	I	-PRON-	PRP
cord-312001-8p7scli8	335	37	pathway	pathway	NN
cord-312001-8p7scli8	335	38	RIG	rig	NN
cord-312001-8p7scli8	335	39	-	-	HYPH
cord-312001-8p7scli8	335	40	I	i	NN
cord-312001-8p7scli8	335	41	-	-	HYPH
cord-312001-8p7scli8	335	42	dependent	dependent	JJ
cord-312001-8p7scli8	335	43	sensing	sensing	NN
cord-312001-8p7scli8	335	44	of	of	IN
cord-312001-8p7scli8	335	45	poly(dA	poly(dA	NNP
cord-312001-8p7scli8	335	46	:	:	:
cord-312001-8p7scli8	335	47	dT	dT	NNP
cord-312001-8p7scli8	335	48	)	)	-RRB-
cord-312001-8p7scli8	335	49	through	through	IN
cord-312001-8p7scli8	335	50	the	the	DT
cord-312001-8p7scli8	335	51	induction	induction	NN
cord-312001-8p7scli8	335	52	of	of	IN
cord-312001-8p7scli8	335	53	an	an	DT
cord-312001-8p7scli8	335	54	RNA	RNA	NNP
cord-312001-8p7scli8	335	55	polymerase	polymerase	NN
cord-312001-8p7scli8	335	56	III	III	NNP
cord-312001-8p7scli8	335	57	-	-	HYPH
cord-312001-8p7scli8	335	58	transcribed	transcribe	VBN
cord-312001-8p7scli8	335	59	RNA	RNA	NNP
cord-312001-8p7scli8	335	60	intermediate	intermediate	JJ
cord-312001-8p7scli8	335	61	DNA	DNA	NNP
cord-312001-8p7scli8	335	62	-	-	HYPH
cord-312001-8p7scli8	335	63	PK	PK	NNP
cord-312001-8p7scli8	335	64	is	be	VBZ
cord-312001-8p7scli8	335	65	a	a	DT
cord-312001-8p7scli8	335	66	DNA	dna	NN
cord-312001-8p7scli8	335	67	sensor	sensor	NN
cord-312001-8p7scli8	335	68	for	for	IN
cord-312001-8p7scli8	335	69	IRF-3-dependent	irf-3-dependent	JJ
cord-312001-8p7scli8	335	70	innate	innate	JJ
cord-312001-8p7scli8	335	71	immunity	immunity	NN
cord-312001-8p7scli8	336	1	DLM-1	DLM-1	NNP
cord-312001-8p7scli8	336	2	/	/	SYM
cord-312001-8p7scli8	336	3	ZBP1	ZBP1	NNP
cord-312001-8p7scli8	336	4	)	)	-RRB-
cord-312001-8p7scli8	336	5	is	be	VBZ
cord-312001-8p7scli8	336	6	a	a	DT
cord-312001-8p7scli8	336	7	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	336	8	DNA	dna	NN
cord-312001-8p7scli8	336	9	sensor	sensor	NN
cord-312001-8p7scli8	336	10	and	and	CC
cord-312001-8p7scli8	336	11	an	an	DT
cord-312001-8p7scli8	336	12	activator	activator	NN
cord-312001-8p7scli8	336	13	of	of	IN
cord-312001-8p7scli8	336	14	innate	innate	JJ
cord-312001-8p7scli8	336	15	immune	immune	JJ
cord-312001-8p7scli8	336	16	response	response	NN
cord-312001-8p7scli8	337	1	The	the	DT
cord-312001-8p7scli8	337	2	interferon	interferon	NN
cord-312001-8p7scli8	337	3	response	response	NN
cord-312001-8p7scli8	337	4	to	to	IN
cord-312001-8p7scli8	337	5	intracellular	intracellular	JJ
cord-312001-8p7scli8	337	6	DNA	dna	NN
cord-312001-8p7scli8	337	7	:	:	:
cord-312001-8p7scli8	337	8	Why	why	WRB
cord-312001-8p7scli8	337	9	so	so	RB
cord-312001-8p7scli8	337	10	many	many	JJ
cord-312001-8p7scli8	337	11	receptors	receptor	NNS
cord-312001-8p7scli8	337	12	?	?	.
cord-312001-8p7scli8	338	1	Immunobiology	Immunobiology	NNP
cord-312001-8p7scli8	338	2	IFI16	IFI16	NNP
cord-312001-8p7scli8	338	3	is	be	VBZ
cord-312001-8p7scli8	338	4	an	an	DT
cord-312001-8p7scli8	338	5	innate	innate	JJ
cord-312001-8p7scli8	338	6	immune	immune	JJ
cord-312001-8p7scli8	338	7	sensor	sensor	NN
cord-312001-8p7scli8	338	8	for	for	IN
cord-312001-8p7scli8	338	9	intracellular	intracellular	JJ
cord-312001-8p7scli8	338	10	DNA	dna	NN
cord-312001-8p7scli8	339	1	The	the	DT
cord-312001-8p7scli8	339	2	helicase	helicase	NN
cord-312001-8p7scli8	339	3	DDX41	ddx41	VBP
cord-312001-8p7scli8	339	4	senses	sense	NNS
cord-312001-8p7scli8	339	5	intracellular	intracellular	JJ
cord-312001-8p7scli8	339	6	DNA	dna	NN
cord-312001-8p7scli8	339	7	mediated	mediate	VBN
cord-312001-8p7scli8	339	8	by	by	IN
cord-312001-8p7scli8	339	9	the	the	DT
cord-312001-8p7scli8	339	10	adaptor	adaptor	NN
cord-312001-8p7scli8	339	11	STING	sting	NN
cord-312001-8p7scli8	339	12	in	in	IN
cord-312001-8p7scli8	339	13	dendritic	dendritic	JJ
cord-312001-8p7scli8	339	14	cells	cell	NNS
cord-312001-8p7scli8	339	15	Adenovirus	Adenovirus	NNP
cord-312001-8p7scli8	339	16	detection	detection	NN
cord-312001-8p7scli8	339	17	by	by	IN
cord-312001-8p7scli8	339	18	the	the	DT
cord-312001-8p7scli8	339	19	cGAS	cgas	NN
cord-312001-8p7scli8	339	20	/	/	SYM
cord-312001-8p7scli8	339	21	STING	sting	NN
cord-312001-8p7scli8	339	22	/	/	SYM
cord-312001-8p7scli8	339	23	TBK1	TBK1	NNP
cord-312001-8p7scli8	339	24	DNA	dna	NN
cord-312001-8p7scli8	339	25	sensing	sensing	NN
cord-312001-8p7scli8	339	26	cascade	cascade	NN
cord-312001-8p7scli8	339	27	Pan	pan	JJ
cord-312001-8p7scli8	339	28	-	-	JJ
cord-312001-8p7scli8	339	29	viral	viral	JJ
cord-312001-8p7scli8	339	30	specificity	specificity	NN
cord-312001-8p7scli8	339	31	of	of	IN
cord-312001-8p7scli8	339	32	IFN	IFN	NNP
cord-312001-8p7scli8	339	33	-	-	HYPH
cord-312001-8p7scli8	339	34	induced	induce	VBN
cord-312001-8p7scli8	339	35	genes	gene	NNS
cord-312001-8p7scli8	340	1	reveals	reveal	VBZ
cord-312001-8p7scli8	340	2	new	new	JJ
cord-312001-8p7scli8	340	3	roles	role	NNS
cord-312001-8p7scli8	340	4	for	for	IN
cord-312001-8p7scli8	340	5	cGAS	cgas	NN
cord-312001-8p7scli8	340	6	in	in	IN
cord-312001-8p7scli8	340	7	innate	innate	JJ
cord-312001-8p7scli8	340	8	immunity	immunity	NN
cord-312001-8p7scli8	341	1	Cyclic	cyclic	JJ
cord-312001-8p7scli8	341	2	GMP	GMP	NNP
cord-312001-8p7scli8	341	3	-	-	HYPH
cord-312001-8p7scli8	341	4	AMP	AMP	NNP
cord-312001-8p7scli8	341	5	is	be	VBZ
cord-312001-8p7scli8	341	6	an	an	DT
cord-312001-8p7scli8	341	7	endogenous	endogenous	JJ
cord-312001-8p7scli8	341	8	second	second	JJ
cord-312001-8p7scli8	341	9	messenger	messenger	NN
cord-312001-8p7scli8	341	10	in	in	IN
cord-312001-8p7scli8	341	11	innate	innate	JJ
cord-312001-8p7scli8	341	12	immune	immune	JJ
cord-312001-8p7scli8	341	13	signaling	signaling	NN
cord-312001-8p7scli8	341	14	by	by	IN
cord-312001-8p7scli8	341	15	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	341	16	DNA	DNA	NNP
cord-312001-8p7scli8	341	17	AIM2	AIM2	NNP
cord-312001-8p7scli8	341	18	recognizes	recognize	VBZ
cord-312001-8p7scli8	341	19	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	341	20	dsDNA	dsdna	RB
cord-312001-8p7scli8	341	21	and	and	CC
cord-312001-8p7scli8	341	22	forms	form	VBZ
cord-312001-8p7scli8	341	23	a	a	DT
cord-312001-8p7scli8	341	24	caspase-1-activating	caspase-1-activate	VBG
cord-312001-8p7scli8	341	25	inflammasome	inflammasome	NN
cord-312001-8p7scli8	341	26	with	with	IN
cord-312001-8p7scli8	341	27	ASC	ASC	NNP
cord-312001-8p7scli8	341	28	TICAM-1	TICAM-1	NNP
cord-312001-8p7scli8	341	29	,	,	,
cord-312001-8p7scli8	341	30	an	an	DT
cord-312001-8p7scli8	341	31	adaptor	adaptor	NN
cord-312001-8p7scli8	341	32	molecule	molecule	NN
cord-312001-8p7scli8	341	33	that	that	WDT
cord-312001-8p7scli8	341	34	participates	participate	VBZ
cord-312001-8p7scli8	341	35	in	in	IN
cord-312001-8p7scli8	341	36	Toll	Toll	NNP
cord-312001-8p7scli8	341	37	-	-	HYPH
cord-312001-8p7scli8	341	38	like	like	JJ
cord-312001-8p7scli8	341	39	receptor	receptor	NN
cord-312001-8p7scli8	341	40	3-mediated	3-mediated	CD
cord-312001-8p7scli8	341	41	interferon	interferon	NN
cord-312001-8p7scli8	341	42	-	-	HYPH
cord-312001-8p7scli8	341	43	beta	beta	NN
cord-312001-8p7scli8	341	44	induction	induction	NN
cord-312001-8p7scli8	341	45	Role	role	NN
cord-312001-8p7scli8	341	46	of	of	IN
cord-312001-8p7scli8	341	47	adaptor	adaptor	NN
cord-312001-8p7scli8	341	48	TRIF	TRIF	NNP
cord-312001-8p7scli8	341	49	in	in	IN
cord-312001-8p7scli8	341	50	the	the	DT
cord-312001-8p7scli8	341	51	MyD88-independent	MyD88-independent	NNP
cord-312001-8p7scli8	341	52	toll	toll	NN
cord-312001-8p7scli8	341	53	-	-	HYPH
cord-312001-8p7scli8	341	54	like	like	JJ
cord-312001-8p7scli8	341	55	receptor	receptor	NN
cord-312001-8p7scli8	341	56	signaling	signal	VBG
cord-312001-8p7scli8	341	57	pathway	pathway	NN
cord-312001-8p7scli8	341	58	Specificity	Specificity	NNP
cord-312001-8p7scli8	341	59	in	in	IN
cord-312001-8p7scli8	341	60	Toll	Toll	NNP
cord-312001-8p7scli8	341	61	-	-	HYPH
cord-312001-8p7scli8	341	62	like	like	JJ
cord-312001-8p7scli8	341	63	receptor	receptor	NN
cord-312001-8p7scli8	341	64	signalling	signal	VBG
cord-312001-8p7scli8	341	65	through	through	IN
cord-312001-8p7scli8	341	66	distinct	distinct	JJ
cord-312001-8p7scli8	341	67	effector	effector	NN
cord-312001-8p7scli8	341	68	functions	function	NNS
cord-312001-8p7scli8	341	69	of	of	IN
cord-312001-8p7scli8	341	70	TRAF3	traf3	NN
cord-312001-8p7scli8	341	71	and	and	CC
cord-312001-8p7scli8	341	72	TRAF6	TRAF6	NNP
cord-312001-8p7scli8	341	73	Critical	critical	JJ
cord-312001-8p7scli8	341	74	role	role	NN
cord-312001-8p7scli8	341	75	of	of	IN
cord-312001-8p7scli8	341	76	TRAF3	traf3	NN
cord-312001-8p7scli8	341	77	in	in	IN
cord-312001-8p7scli8	341	78	the	the	DT
cord-312001-8p7scli8	341	79	Toll	Toll	NNP
cord-312001-8p7scli8	341	80	-	-	HYPH
cord-312001-8p7scli8	341	81	like	like	JJ
cord-312001-8p7scli8	341	82	receptor	receptor	NN
cord-312001-8p7scli8	341	83	-	-	HYPH
cord-312001-8p7scli8	341	84	dependent	dependent	JJ
cord-312001-8p7scli8	341	85	and	and	CC
cord-312001-8p7scli8	341	86	-independent	-independent	JJ
cord-312001-8p7scli8	342	1	antiviral	antiviral	JJ
cord-312001-8p7scli8	342	2	response	response	NN
cord-312001-8p7scli8	342	3	Type	type	NN
cord-312001-8p7scli8	343	1	I	-PRON-	PRP
cord-312001-8p7scli8	343	2	interferon	interferon	VBP
cord-312001-8p7scli8	343	3	[	[	-LRB-
cord-312001-8p7scli8	343	4	corrected	correct	VBD
cord-312001-8p7scli8	343	5	]	]	-RRB-
cord-312001-8p7scli8	343	6	gene	gene	NN
cord-312001-8p7scli8	343	7	induction	induction	NN
cord-312001-8p7scli8	343	8	by	by	IN
cord-312001-8p7scli8	343	9	the	the	DT
cord-312001-8p7scli8	343	10	interferon	interferon	NN
cord-312001-8p7scli8	343	11	regulatory	regulatory	JJ
cord-312001-8p7scli8	343	12	factor	factor	NN
cord-312001-8p7scli8	343	13	family	family	NN
cord-312001-8p7scli8	343	14	of	of	IN
cord-312001-8p7scli8	343	15	transcription	transcription	NN
cord-312001-8p7scli8	343	16	factors	factor	NNS
cord-312001-8p7scli8	344	1	Cutting	cut	VBG
cord-312001-8p7scli8	344	2	edge	edge	NN
cord-312001-8p7scli8	344	3	:	:	:
cord-312001-8p7scli8	344	4	TNFR	TNFR	NNP
cord-312001-8p7scli8	344	5	-	-	HYPH
cord-312001-8p7scli8	344	6	associated	associate	VBN
cord-312001-8p7scli8	344	7	factor	factor	NN
cord-312001-8p7scli8	344	8	(	(	-LRB-
cord-312001-8p7scli8	344	9	TRAF	TRAF	NNP
cord-312001-8p7scli8	344	10	)	)	-RRB-
cord-312001-8p7scli8	344	11	6	6	CD
cord-312001-8p7scli8	344	12	is	be	VBZ
cord-312001-8p7scli8	344	13	essential	essential	JJ
cord-312001-8p7scli8	344	14	for	for	IN
cord-312001-8p7scli8	344	15	MyD88-dependent	MyD88-dependent	NNP
cord-312001-8p7scli8	344	16	pathway	pathway	NN
cord-312001-8p7scli8	344	17	but	but	CC
cord-312001-8p7scli8	345	1	not	not	RB
cord-312001-8p7scli8	345	2	toll/	toll/	CD
cord-312001-8p7scli8	346	1	IL-1	IL-1	NNP
cord-312001-8p7scli8	346	2	receptor	receptor	NN
cord-312001-8p7scli8	346	3	domain	domain	NN
cord-312001-8p7scli8	346	4	-	-	HYPH
cord-312001-8p7scli8	346	5	containing	contain	VBG
cord-312001-8p7scli8	346	6	adaptor	adaptor	NN
cord-312001-8p7scli8	346	7	-	-	HYPH
cord-312001-8p7scli8	346	8	inducing	induce	VBG
cord-312001-8p7scli8	346	9	IFN	IFN	NNP
cord-312001-8p7scli8	346	10	-	-	HYPH
cord-312001-8p7scli8	346	11	beta	beta	NN
cord-312001-8p7scli8	346	12	(	(	-LRB-
cord-312001-8p7scli8	346	13	TRIF)-dependent	trif)-dependent	CD
cord-312001-8p7scli8	346	14	pathway	pathway	NN
cord-312001-8p7scli8	346	15	in	in	IN
cord-312001-8p7scli8	346	16	TLR	TLR	NNP
cord-312001-8p7scli8	346	17	signaling	signal	VBG
cord-312001-8p7scli8	346	18	Interferon	Interferon	NNP
cord-312001-8p7scli8	346	19	-	-	HYPH
cord-312001-8p7scli8	346	20	alpha	alpha	NN
cord-312001-8p7scli8	346	21	induction	induction	NN
cord-312001-8p7scli8	346	22	through	through	IN
cord-312001-8p7scli8	346	23	Toll	Toll	NNP
cord-312001-8p7scli8	346	24	-	-	HYPH
cord-312001-8p7scli8	346	25	like	like	JJ
cord-312001-8p7scli8	346	26	receptors	receptor	NNS
cord-312001-8p7scli8	347	1	involves	involve	VBZ
cord-312001-8p7scli8	347	2	a	a	DT
cord-312001-8p7scli8	347	3	direct	direct	JJ
cord-312001-8p7scli8	347	4	interaction	interaction	NN
cord-312001-8p7scli8	347	5	of	of	IN
cord-312001-8p7scli8	347	6	IRF7	IRF7	NNP
cord-312001-8p7scli8	347	7	with	with	IN
cord-312001-8p7scli8	347	8	MyD88	MyD88	NNP
cord-312001-8p7scli8	347	9	and	and	CC
cord-312001-8p7scli8	347	10	TRAF6	TRAF6	NNP
cord-312001-8p7scli8	347	11	Helical	Helical	NNP
cord-312001-8p7scli8	347	12	assembly	assembly	NN
cord-312001-8p7scli8	347	13	in	in	IN
cord-312001-8p7scli8	347	14	the	the	DT
cord-312001-8p7scli8	347	15	MyD88-IRAK4-IRAK2	MyD88-IRAK4-IRAK2	NNP
cord-312001-8p7scli8	347	16	complex	complex	NN
cord-312001-8p7scli8	347	17	in	in	IN
cord-312001-8p7scli8	347	18	TLR	TLR	NNP
cord-312001-8p7scli8	347	19	/	/	SYM
cord-312001-8p7scli8	347	20	IL-1R	IL-1R	NNP
cord-312001-8p7scli8	347	21	signalling	signal	VBG
cord-312001-8p7scli8	347	22	Protein	Protein	NNP
cord-312001-8p7scli8	347	23	kinase	kinase	NN
cord-312001-8p7scli8	347	24	IKKbeta	ikkbeta	NN
cord-312001-8p7scli8	347	25	-	-	HYPH
cord-312001-8p7scli8	347	26	catalyzed	catalyze	VBN
cord-312001-8p7scli8	347	27	phosphorylation	phosphorylation	NN
cord-312001-8p7scli8	347	28	of	of	IN
cord-312001-8p7scli8	347	29	IRF5	IRF5	NNP
cord-312001-8p7scli8	347	30	at	at	IN
cord-312001-8p7scli8	347	31	Ser462	ser462	CD
cord-312001-8p7scli8	348	1	induces	induce	VBZ
cord-312001-8p7scli8	348	2	its	-PRON-	PRP$
cord-312001-8p7scli8	348	3	dimerization	dimerization	NN
cord-312001-8p7scli8	348	4	and	and	CC
cord-312001-8p7scli8	348	5	nuclear	nuclear	JJ
cord-312001-8p7scli8	348	6	translocation	translocation	NN
cord-312001-8p7scli8	348	7	in	in	IN
cord-312001-8p7scli8	348	8	myeloid	myeloid	JJ
cord-312001-8p7scli8	348	9	cells	cell	NNS
cord-312001-8p7scli8	349	1	An	an	DT
cord-312001-8p7scli8	349	2	oligomeric	oligomeric	JJ
cord-312001-8p7scli8	349	3	signaling	signal	VBG
cord-312001-8p7scli8	349	4	platform	platform	NN
cord-312001-8p7scli8	349	5	formed	form	VBN
cord-312001-8p7scli8	349	6	by	by	IN
cord-312001-8p7scli8	349	7	the	the	DT
cord-312001-8p7scli8	349	8	Toll	Toll	NNP
cord-312001-8p7scli8	349	9	-	-	HYPH
cord-312001-8p7scli8	349	10	like	like	JJ
cord-312001-8p7scli8	349	11	receptor	receptor	NN
cord-312001-8p7scli8	349	12	signal	signal	NN
cord-312001-8p7scli8	349	13	transducers	transducer	NNS
cord-312001-8p7scli8	349	14	MyD88	MyD88	NNS
cord-312001-8p7scli8	349	15	and	and	CC
cord-312001-8p7scli8	349	16	IRAK-4	irak-4	JJ
cord-312001-8p7scli8	349	17	IKKbeta	ikkbeta	NN
cord-312001-8p7scli8	349	18	is	be	VBZ
cord-312001-8p7scli8	349	19	an	an	DT
cord-312001-8p7scli8	349	20	IRF5	IRF5	NNP
cord-312001-8p7scli8	349	21	kinase	kinase	NN
cord-312001-8p7scli8	349	22	that	that	WDT
cord-312001-8p7scli8	349	23	instigates	instigate	VBZ
cord-312001-8p7scli8	349	24	inflammation	inflammation	NN
cord-312001-8p7scli8	349	25	Interleukin-1	Interleukin-1	NNP
cord-312001-8p7scli8	349	26	receptor	receptor	NN
cord-312001-8p7scli8	349	27	-	-	HYPH
cord-312001-8p7scli8	349	28	associated	associate	VBN
cord-312001-8p7scli8	349	29	kinase-1	kinase-1	NNP
cord-312001-8p7scli8	350	1	plays	play	VBZ
cord-312001-8p7scli8	350	2	an	an	DT
cord-312001-8p7scli8	350	3	essential	essential	JJ
cord-312001-8p7scli8	350	4	role	role	NN
cord-312001-8p7scli8	350	5	for	for	IN
cord-312001-8p7scli8	350	6	Toll	toll	NN
cord-312001-8p7scli8	350	7	-	-	HYPH
cord-312001-8p7scli8	350	8	like	like	JJ
cord-312001-8p7scli8	350	9	receptor	receptor	NN
cord-312001-8p7scli8	350	10	(	(	-LRB-
cord-312001-8p7scli8	350	11	TLR)7-and	tlr)7-and	JJ
cord-312001-8p7scli8	350	12	TLR9-mediated	tlr9-mediated	JJ
cord-312001-8p7scli8	350	13	interferon-{alpha	interferon-{alpha	NN
cord-312001-8p7scli8	350	14	}	}	-RRB-
cord-312001-8p7scli8	350	15	induction	induction	NN
cord-312001-8p7scli8	350	16	Structural	structural	JJ
cord-312001-8p7scli8	350	17	basis	basis	NN
cord-312001-8p7scli8	350	18	of	of	IN
cord-312001-8p7scli8	350	19	RNA	RNA	NNP
cord-312001-8p7scli8	350	20	recognition	recognition	NN
cord-312001-8p7scli8	350	21	and	and	CC
cord-312001-8p7scli8	350	22	activation	activation	NN
cord-312001-8p7scli8	350	23	by	by	IN
cord-312001-8p7scli8	350	24	innate	innate	JJ
cord-312001-8p7scli8	350	25	immune	immune	JJ
cord-312001-8p7scli8	350	26	receptor	receptor	NN
cord-312001-8p7scli8	350	27	RIG	rig	NN
cord-312001-8p7scli8	350	28	-	-	:
cord-312001-8p7scli8	350	29	I	I	NNP
cord-312001-8p7scli8	350	30	Structural	structural	JJ
cord-312001-8p7scli8	350	31	basis	basis	NN
cord-312001-8p7scli8	350	32	for	for	IN
cord-312001-8p7scli8	350	33	the	the	DT
cord-312001-8p7scli8	350	34	activation	activation	NN
cord-312001-8p7scli8	350	35	of	of	IN
cord-312001-8p7scli8	350	36	innate	innate	JJ
cord-312001-8p7scli8	350	37	immune	immune	JJ
cord-312001-8p7scli8	350	38	pattern	pattern	NN
cord-312001-8p7scli8	350	39	-	-	HYPH
cord-312001-8p7scli8	350	40	recognition	recognition	NN
cord-312001-8p7scli8	350	41	receptor	receptor	NN
cord-312001-8p7scli8	350	42	RIG	rig	NN
cord-312001-8p7scli8	351	1	-I	-I	NFP
cord-312001-8p7scli8	351	2	by	by	IN
cord-312001-8p7scli8	351	3	viral	viral	JJ
cord-312001-8p7scli8	351	4	RNA	RNA	NNP
cord-312001-8p7scli8	351	5	MDA5	MDA5	NNP
cord-312001-8p7scli8	351	6	assembles	assemble	VBZ
cord-312001-8p7scli8	351	7	into	into	IN
cord-312001-8p7scli8	351	8	a	a	DT
cord-312001-8p7scli8	351	9	polar	polar	JJ
cord-312001-8p7scli8	351	10	helical	helical	JJ
cord-312001-8p7scli8	351	11	filament	filament	NN
cord-312001-8p7scli8	351	12	on	on	IN
cord-312001-8p7scli8	351	13	dsRNA	dsrna	NN
cord-312001-8p7scli8	352	1	Cooperative	cooperative	JJ
cord-312001-8p7scli8	352	2	assembly	assembly	NN
cord-312001-8p7scli8	352	3	and	and	CC
cord-312001-8p7scli8	352	4	dynamic	dynamic	JJ
cord-312001-8p7scli8	352	5	disassembly	disassembly	NN
cord-312001-8p7scli8	352	6	of	of	IN
cord-312001-8p7scli8	352	7	MDA5	mda5	JJ
cord-312001-8p7scli8	352	8	filaments	filament	NNS
cord-312001-8p7scli8	352	9	for	for	IN
cord-312001-8p7scli8	352	10	viral	viral	JJ
cord-312001-8p7scli8	352	11	dsRNA	dsrna	NN
cord-312001-8p7scli8	352	12	recognition	recognition	NN
cord-312001-8p7scli8	352	13	TRIM25	TRIM25	NNP
cord-312001-8p7scli8	352	14	RING	ring	NN
cord-312001-8p7scli8	352	15	-	-	HYPH
cord-312001-8p7scli8	352	16	finger	finger	NN
cord-312001-8p7scli8	352	17	E3	e3	NN
cord-312001-8p7scli8	352	18	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	352	19	ligase	ligase	NN
cord-312001-8p7scli8	352	20	is	be	VBZ
cord-312001-8p7scli8	352	21	essential	essential	JJ
cord-312001-8p7scli8	352	22	for	for	IN
cord-312001-8p7scli8	352	23	RIG	rig	NN
cord-312001-8p7scli8	352	24	-	-	HYPH
cord-312001-8p7scli8	352	25	I	i	NN
cord-312001-8p7scli8	352	26	-	-	HYPH
cord-312001-8p7scli8	352	27	mediated	mediate	VBN
cord-312001-8p7scli8	352	28	antiviral	antiviral	JJ
cord-312001-8p7scli8	352	29	activity	activity	NN
cord-312001-8p7scli8	352	30	Ubiquitin	Ubiquitin	NNP
cord-312001-8p7scli8	352	31	-	-	HYPH
cord-312001-8p7scli8	352	32	induced	induce	VBN
cord-312001-8p7scli8	352	33	oligomerization	oligomerization	NN
cord-312001-8p7scli8	352	34	of	of	IN
cord-312001-8p7scli8	352	35	the	the	DT
cord-312001-8p7scli8	352	36	RNA	RNA	NNP
cord-312001-8p7scli8	352	37	sensors	sensor	NNS
cord-312001-8p7scli8	352	38	RIG	rig	NN
cord-312001-8p7scli8	352	39	-	-	:
cord-312001-8p7scli8	352	40	I	I	NNP
cord-312001-8p7scli8	352	41	and	and	CC
cord-312001-8p7scli8	352	42	MDA5	MDA5	NNP
cord-312001-8p7scli8	352	43	activates	activate	VBZ
cord-312001-8p7scli8	352	44	antiviral	antiviral	JJ
cord-312001-8p7scli8	352	45	innate	innate	JJ
cord-312001-8p7scli8	352	46	immune	immune	JJ
cord-312001-8p7scli8	352	47	response	response	NN
cord-312001-8p7scli8	353	1	Riplet	Riplet	NNP
cord-312001-8p7scli8	353	2	/	/	SYM
cord-312001-8p7scli8	353	3	RNF135	RNF135	NNS
cord-312001-8p7scli8	353	4	,	,	,
cord-312001-8p7scli8	353	5	a	a	DT
cord-312001-8p7scli8	353	6	RING	ring	NN
cord-312001-8p7scli8	353	7	finger	finger	NN
cord-312001-8p7scli8	353	8	protein	protein	NN
cord-312001-8p7scli8	353	9	,	,	,
cord-312001-8p7scli8	353	10	ubiquitinates	ubiquitinates	NNP
cord-312001-8p7scli8	353	11	RIG	RIG	NNP
cord-312001-8p7scli8	353	12	-	-	:
cord-312001-8p7scli8	353	13	I	I	NNP
cord-312001-8p7scli8	354	1	to	to	TO
cord-312001-8p7scli8	354	2	promote	promote	VB
cord-312001-8p7scli8	354	3	interferon	interferon	NN
cord-312001-8p7scli8	354	4	-	-	HYPH
cord-312001-8p7scli8	354	5	beta	beta	NN
cord-312001-8p7scli8	354	6	induction	induction	NN
cord-312001-8p7scli8	354	7	during	during	IN
cord-312001-8p7scli8	354	8	the	the	DT
cord-312001-8p7scli8	354	9	early	early	JJ
cord-312001-8p7scli8	354	10	phase	phase	NN
cord-312001-8p7scli8	354	11	of	of	IN
cord-312001-8p7scli8	354	12	viral	viral	JJ
cord-312001-8p7scli8	354	13	infection	infection	NN
cord-312001-8p7scli8	355	1	The	the	DT
cord-312001-8p7scli8	355	2	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	355	3	ligase	ligase	NN
cord-312001-8p7scli8	355	4	Riplet	Riplet	NNP
cord-312001-8p7scli8	355	5	is	be	VBZ
cord-312001-8p7scli8	355	6	essential	essential	JJ
cord-312001-8p7scli8	355	7	for	for	IN
cord-312001-8p7scli8	355	8	RIG	rig	NN
cord-312001-8p7scli8	355	9	-	-	HYPH
cord-312001-8p7scli8	355	10	I	i	NN
cord-312001-8p7scli8	355	11	-	-	HYPH
cord-312001-8p7scli8	355	12	dependent	dependent	JJ
cord-312001-8p7scli8	355	13	innate	innate	JJ
cord-312001-8p7scli8	355	14	immune	immune	JJ
cord-312001-8p7scli8	355	15	responses	response	NNS
cord-312001-8p7scli8	355	16	to	to	IN
cord-312001-8p7scli8	355	17	RNA	RNA	NNP
cord-312001-8p7scli8	355	18	virus	virus	NN
cord-312001-8p7scli8	355	19	infection	infection	NN
cord-312001-8p7scli8	355	20	IPS-1	IPS-1	NNP
cord-312001-8p7scli8	355	21	,	,	,
cord-312001-8p7scli8	355	22	an	an	DT
cord-312001-8p7scli8	355	23	adaptor	adaptor	NN
cord-312001-8p7scli8	355	24	triggering	trigger	VBG
cord-312001-8p7scli8	355	25	RIG	rig	NN
cord-312001-8p7scli8	355	26	-	-	HYPH
cord-312001-8p7scli8	355	27	I	i	NN
cord-312001-8p7scli8	355	28	-	-	HYPH
cord-312001-8p7scli8	355	29	and	and	CC
cord-312001-8p7scli8	355	30	Mda5-mediated	Mda5-mediated	NNP
cord-312001-8p7scli8	356	1	type	type	NN
cord-312001-8p7scli8	357	1	I	-PRON-	PRP
cord-312001-8p7scli8	358	1	interferon	interferon	NNP
cord-312001-8p7scli8	358	2	induction	induction	NN
cord-312001-8p7scli8	358	3	Cardif	Cardif	NNP
cord-312001-8p7scli8	358	4	is	be	VBZ
cord-312001-8p7scli8	358	5	an	an	DT
cord-312001-8p7scli8	358	6	adaptor	adaptor	NN
cord-312001-8p7scli8	358	7	protein	protein	NN
cord-312001-8p7scli8	358	8	in	in	IN
cord-312001-8p7scli8	358	9	the	the	DT
cord-312001-8p7scli8	358	10	RIG	rig	NN
cord-312001-8p7scli8	358	11	-	-	:
cord-312001-8p7scli8	358	12	I	I	NNP
cord-312001-8p7scli8	358	13	antiviral	antiviral	JJ
cord-312001-8p7scli8	358	14	pathway	pathway	NN
cord-312001-8p7scli8	358	15	and	and	CC
cord-312001-8p7scli8	358	16	is	be	VBZ
cord-312001-8p7scli8	358	17	targeted	target	VBN
cord-312001-8p7scli8	358	18	by	by	IN
cord-312001-8p7scli8	358	19	hepatitis	hepatitis	NN
cord-312001-8p7scli8	358	20	C	C	NNP
cord-312001-8p7scli8	358	21	virus	virus	NN
cord-312001-8p7scli8	358	22	Identification	identification	NN
cord-312001-8p7scli8	358	23	and	and	CC
cord-312001-8p7scli8	358	24	characterization	characterization	NN
cord-312001-8p7scli8	358	25	of	of	IN
cord-312001-8p7scli8	358	26	MAVS	MAVS	NNPS
cord-312001-8p7scli8	358	27	,	,	,
cord-312001-8p7scli8	358	28	a	a	DT
cord-312001-8p7scli8	358	29	mitochondrial	mitochondrial	JJ
cord-312001-8p7scli8	358	30	antiviral	antiviral	JJ
cord-312001-8p7scli8	358	31	signaling	signal	VBG
cord-312001-8p7scli8	358	32	protein	protein	NN
cord-312001-8p7scli8	358	33	that	that	WDT
cord-312001-8p7scli8	358	34	activates	activate	VBZ
cord-312001-8p7scli8	358	35	NF	NF	NNP
cord-312001-8p7scli8	358	36	-	-	HYPH
cord-312001-8p7scli8	358	37	kappaB	kappaB	NNP
cord-312001-8p7scli8	358	38	and	and	CC
cord-312001-8p7scli8	358	39	IRF	IRF	NNP
cord-312001-8p7scli8	358	40	3	3	CD
cord-312001-8p7scli8	358	41	Essential	essential	JJ
cord-312001-8p7scli8	358	42	role	role	NN
cord-312001-8p7scli8	358	43	of	of	IN
cord-312001-8p7scli8	358	44	IPS-1	IPS-1	NNP
cord-312001-8p7scli8	358	45	in	in	IN
cord-312001-8p7scli8	358	46	innate	innate	JJ
cord-312001-8p7scli8	358	47	immune	immune	JJ
cord-312001-8p7scli8	358	48	responses	response	NNS
cord-312001-8p7scli8	358	49	against	against	IN
cord-312001-8p7scli8	358	50	RNA	RNA	NNP
cord-312001-8p7scli8	358	51	viruses	virus	NNS
cord-312001-8p7scli8	359	1	An	an	DT
cord-312001-8p7scli8	359	2	autoinhibitory	autoinhibitory	JJ
cord-312001-8p7scli8	359	3	mechanism	mechanism	NN
cord-312001-8p7scli8	359	4	modulates	modulate	VBZ
cord-312001-8p7scli8	359	5	MAVS	MAVS	NNP
cord-312001-8p7scli8	359	6	activity	activity	NN
cord-312001-8p7scli8	359	7	in	in	IN
cord-312001-8p7scli8	359	8	antiviral	antiviral	JJ
cord-312001-8p7scli8	359	9	innate	innate	JJ
cord-312001-8p7scli8	359	10	immune	immune	JJ
cord-312001-8p7scli8	359	11	response	response	NN
cord-312001-8p7scli8	360	1	MAVS	MAVS	NNP
cord-312001-8p7scli8	360	2	forms	form	VBZ
cord-312001-8p7scli8	360	3	functional	functional	JJ
cord-312001-8p7scli8	360	4	prion	prion	NN
cord-312001-8p7scli8	360	5	-	-	HYPH
cord-312001-8p7scli8	360	6	like	like	JJ
cord-312001-8p7scli8	360	7	aggregates	aggregate	NNS
cord-312001-8p7scli8	360	8	to	to	TO
cord-312001-8p7scli8	360	9	activate	activate	VB
cord-312001-8p7scli8	360	10	and	and	CC
cord-312001-8p7scli8	360	11	propagate	propagate	VB
cord-312001-8p7scli8	360	12	antiviral	antiviral	JJ
cord-312001-8p7scli8	360	13	innate	innate	JJ
cord-312001-8p7scli8	360	14	immune	immune	JJ
cord-312001-8p7scli8	360	15	response	response	NN
cord-312001-8p7scli8	361	1	Structural	structural	JJ
cord-312001-8p7scli8	361	2	basis	basis	NN
cord-312001-8p7scli8	361	3	for	for	IN
cord-312001-8p7scli8	361	4	the	the	DT
cord-312001-8p7scli8	361	5	prion	prion	NN
cord-312001-8p7scli8	361	6	-	-	HYPH
cord-312001-8p7scli8	361	7	like	like	IN
cord-312001-8p7scli8	361	8	MAVS	MAVS	NNP
cord-312001-8p7scli8	361	9	filaments	filament	NNS
cord-312001-8p7scli8	361	10	in	in	IN
cord-312001-8p7scli8	361	11	antiviral	antiviral	JJ
cord-312001-8p7scli8	361	12	innate	innate	JJ
cord-312001-8p7scli8	361	13	immunity	immunity	NN
cord-312001-8p7scli8	361	14	MAVS	MAVS	NNPS
cord-312001-8p7scli8	361	15	recruits	recruit	VBZ
cord-312001-8p7scli8	361	16	multiple	multiple	JJ
cord-312001-8p7scli8	361	17	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	361	18	E3	e3	NN
cord-312001-8p7scli8	361	19	ligases	ligase	NNS
cord-312001-8p7scli8	361	20	to	to	TO
cord-312001-8p7scli8	361	21	activate	activate	VB
cord-312001-8p7scli8	361	22	antiviral	antiviral	JJ
cord-312001-8p7scli8	361	23	signaling	signaling	NN
cord-312001-8p7scli8	361	24	cascades	cascade	NNS
cord-312001-8p7scli8	361	25	Activation	Activation	NNP
cord-312001-8p7scli8	361	26	of	of	IN
cord-312001-8p7scli8	361	27	IKK	IKK	NNP
cord-312001-8p7scli8	361	28	by	by	IN
cord-312001-8p7scli8	361	29	TNFalpha	TNFalpha	NNP
cord-312001-8p7scli8	361	30	requires	require	VBZ
cord-312001-8p7scli8	361	31	site	site	NN
cord-312001-8p7scli8	361	32	-	-	HYPH
cord-312001-8p7scli8	361	33	specific	specific	JJ
cord-312001-8p7scli8	361	34	ubiquitination	ubiquitination	NN
cord-312001-8p7scli8	361	35	of	of	IN
cord-312001-8p7scli8	361	36	RIP1	RIP1	NNP
cord-312001-8p7scli8	361	37	and	and	CC
cord-312001-8p7scli8	361	38	polyubiquitin	polyubiquitin	NNP
cord-312001-8p7scli8	361	39	binding	bind	VBG
cord-312001-8p7scli8	361	40	by	by	IN
cord-312001-8p7scli8	361	41	NEMO	NEMO	NNP
cord-312001-8p7scli8	361	42	Sensing	Sensing	NNP
cord-312001-8p7scli8	361	43	of	of	IN
cord-312001-8p7scli8	361	44	Lys	Lys	NNP
cord-312001-8p7scli8	362	1	63-linked	63-linked	CD
cord-312001-8p7scli8	362	2	polyubiquitination	polyubiquitination	NN
cord-312001-8p7scli8	362	3	by	by	IN
cord-312001-8p7scli8	362	4	NEMO	NEMO	NNP
cord-312001-8p7scli8	362	5	is	be	VBZ
cord-312001-8p7scli8	362	6	a	a	DT
cord-312001-8p7scli8	362	7	key	key	JJ
cord-312001-8p7scli8	362	8	event	event	NN
cord-312001-8p7scli8	362	9	in	in	IN
cord-312001-8p7scli8	362	10	NF	NF	NNP
cord-312001-8p7scli8	362	11	-	-	HYPH
cord-312001-8p7scli8	362	12	kappaB	kappaB	NNP
cord-312001-8p7scli8	362	13	activation	activation	NN
cord-312001-8p7scli8	362	14	Key	key	JJ
cord-312001-8p7scli8	362	15	role	role	NN
cord-312001-8p7scli8	362	16	of	of	IN
cord-312001-8p7scli8	362	17	Ubc5	Ubc5	NNP
cord-312001-8p7scli8	362	18	and	and	CC
cord-312001-8p7scli8	362	19	lysine-63	lysine-63	NNP
cord-312001-8p7scli8	362	20	polyubiquitination	polyubiquitination	NN
cord-312001-8p7scli8	362	21	in	in	IN
cord-312001-8p7scli8	362	22	viral	viral	JJ
cord-312001-8p7scli8	362	23	activation	activation	NN
cord-312001-8p7scli8	362	24	of	of	IN
cord-312001-8p7scli8	362	25	IRF3	IRF3	NNP
cord-312001-8p7scli8	362	26	STING	sting	NN
cord-312001-8p7scli8	362	27	is	be	VBZ
cord-312001-8p7scli8	362	28	an	an	DT
cord-312001-8p7scli8	362	29	endoplasmic	endoplasmic	NN
cord-312001-8p7scli8	362	30	reticulum	reticulum	NN
cord-312001-8p7scli8	362	31	adaptor	adaptor	NN
cord-312001-8p7scli8	362	32	that	that	WDT
cord-312001-8p7scli8	362	33	facilitates	facilitate	VBZ
cord-312001-8p7scli8	362	34	innate	innate	JJ
cord-312001-8p7scli8	362	35	immune	immune	NN
cord-312001-8p7scli8	362	36	signalling	signal	VBG
cord-312001-8p7scli8	362	37	The	the	DT
cord-312001-8p7scli8	362	38	adaptor	adaptor	NN
cord-312001-8p7scli8	362	39	protein	protein	NN
cord-312001-8p7scli8	362	40	MITA	MITA	NNP
cord-312001-8p7scli8	362	41	links	link	VBZ
cord-312001-8p7scli8	362	42	virus	virus	NN
cord-312001-8p7scli8	362	43	-	-	HYPH
cord-312001-8p7scli8	362	44	sensing	sense	VBG
cord-312001-8p7scli8	362	45	receptors	receptor	NNS
cord-312001-8p7scli8	362	46	to	to	IN
cord-312001-8p7scli8	362	47	IRF3	IRF3	NNP
cord-312001-8p7scli8	362	48	transcription	transcription	NN
cord-312001-8p7scli8	362	49	factor	factor	NN
cord-312001-8p7scli8	362	50	activation	activation	NN
cord-312001-8p7scli8	362	51	STING	sting	NN
cord-312001-8p7scli8	362	52	regulates	regulate	VBZ
cord-312001-8p7scli8	363	1	intracellular	intracellular	JJ
cord-312001-8p7scli8	363	2	DNA	dna	NN
cord-312001-8p7scli8	363	3	-	-	HYPH
cord-312001-8p7scli8	363	4	mediated	mediate	VBN
cord-312001-8p7scli8	363	5	,	,	,
cord-312001-8p7scli8	364	1	type	type	NN
cord-312001-8p7scli8	364	2	I	-PRON-	PRP
cord-312001-8p7scli8	364	3	interferon	interferon	NN
cord-312001-8p7scli8	364	4	-	-	HYPH
cord-312001-8p7scli8	364	5	dependent	dependent	JJ
cord-312001-8p7scli8	364	6	innate	innate	JJ
cord-312001-8p7scli8	364	7	immunity	immunity	NN
cord-312001-8p7scli8	364	8	STING	sting	NN
cord-312001-8p7scli8	364	9	is	be	VBZ
cord-312001-8p7scli8	364	10	a	a	DT
cord-312001-8p7scli8	364	11	direct	direct	JJ
cord-312001-8p7scli8	364	12	innate	innate	JJ
cord-312001-8p7scli8	364	13	immune	immune	JJ
cord-312001-8p7scli8	364	14	sensor	sensor	NN
cord-312001-8p7scli8	364	15	of	of	IN
cord-312001-8p7scli8	364	16	cyclic	cyclic	JJ
cord-312001-8p7scli8	364	17	di	di	FW
cord-312001-8p7scli8	364	18	-	-	HYPH
cord-312001-8p7scli8	364	19	GMP	GMP	NNP
cord-312001-8p7scli8	364	20	Coordinated	Coordinated	NNP
cord-312001-8p7scli8	364	21	regulation	regulation	NN
cord-312001-8p7scli8	364	22	of	of	IN
cord-312001-8p7scli8	364	23	accessory	accessory	JJ
cord-312001-8p7scli8	364	24	genetic	genetic	JJ
cord-312001-8p7scli8	364	25	elements	element	NNS
cord-312001-8p7scli8	364	26	produces	produce	VBZ
cord-312001-8p7scli8	364	27	cyclic	cyclic	JJ
cord-312001-8p7scli8	364	28	di	di	NN
cord-312001-8p7scli8	364	29	-	-	HYPH
cord-312001-8p7scli8	364	30	nucleotides	nucleotide	NNS
cord-312001-8p7scli8	364	31	for	for	IN
cord-312001-8p7scli8	364	32	V.	V.	NNP
cord-312001-8p7scli8	364	33	cholerae	cholerae	NN
cord-312001-8p7scli8	364	34	virulence	virulence	NN
cord-312001-8p7scli8	364	35	MPYS	MPYS	NNP
cord-312001-8p7scli8	364	36	is	be	VBZ
cord-312001-8p7scli8	364	37	required	require	VBN
cord-312001-8p7scli8	364	38	for	for	IN
cord-312001-8p7scli8	364	39	IFN	IFN	NNP
cord-312001-8p7scli8	364	40	response	response	NN
cord-312001-8p7scli8	364	41	factor	factor	NN
cord-312001-8p7scli8	364	42	3	3	CD
cord-312001-8p7scli8	364	43	activation	activation	NN
cord-312001-8p7scli8	364	44	and	and	CC
cord-312001-8p7scli8	364	45	type	type	NN
cord-312001-8p7scli8	364	46	I	-PRON-	PRP
cord-312001-8p7scli8	364	47	IFN	IFN	NNP
cord-312001-8p7scli8	364	48	production	production	NN
cord-312001-8p7scli8	364	49	in	in	IN
cord-312001-8p7scli8	364	50	the	the	DT
cord-312001-8p7scli8	364	51	response	response	NN
cord-312001-8p7scli8	364	52	of	of	IN
cord-312001-8p7scli8	364	53	cultured	cultured	JJ
cord-312001-8p7scli8	364	54	phagocytes	phagocyte	NNS
cord-312001-8p7scli8	364	55	to	to	TO
cord-312001-8p7scli8	364	56	bacterial	bacterial	JJ
cord-312001-8p7scli8	364	57	second	second	JJ
cord-312001-8p7scli8	364	58	messengers	messenger	NNS
cord-312001-8p7scli8	364	59	cyclic	cyclic	JJ
cord-312001-8p7scli8	364	60	-	-	HYPH
cord-312001-8p7scli8	364	61	di	di	FW
cord-312001-8p7scli8	364	62	-	-	HYPH
cord-312001-8p7scli8	364	63	AMP	amp	NN
cord-312001-8p7scli8	364	64	and	and	CC
cord-312001-8p7scli8	364	65	cyclic	cyclic	JJ
cord-312001-8p7scli8	364	66	-	-	HYPH
cord-312001-8p7scli8	364	67	di	di	FW
cord-312001-8p7scli8	364	68	-	-	HYPH
cord-312001-8p7scli8	364	69	GMP	GMP	NNP
cord-312001-8p7scli8	365	1	The	the	DT
cord-312001-8p7scli8	365	2	N	N	NNP
cord-312001-8p7scli8	365	3	-	-	HYPH
cord-312001-8p7scli8	365	4	ethyl	ethyl	NNP
cord-312001-8p7scli8	365	5	-	-	HYPH
cord-312001-8p7scli8	365	6	N	N	NNP
cord-312001-8p7scli8	365	7	-	-	HYPH
cord-312001-8p7scli8	365	8	nitrosourea	nitrosourea	NN
cord-312001-8p7scli8	365	9	-	-	HYPH
cord-312001-8p7scli8	365	10	induced	induce	VBN
cord-312001-8p7scli8	365	11	Goldenticket	Goldenticket	NNP
cord-312001-8p7scli8	365	12	mouse	mouse	NN
cord-312001-8p7scli8	365	13	mutant	mutant	NN
cord-312001-8p7scli8	365	14	reveals	reveal	VBZ
cord-312001-8p7scli8	365	15	an	an	DT
cord-312001-8p7scli8	365	16	essential	essential	JJ
cord-312001-8p7scli8	365	17	function	function	NN
cord-312001-8p7scli8	365	18	of	of	IN
cord-312001-8p7scli8	365	19	Sting	Sting	NNP
cord-312001-8p7scli8	365	20	in	in	IN
cord-312001-8p7scli8	365	21	the	the	DT
cord-312001-8p7scli8	365	22	in	in	IN
cord-312001-8p7scli8	365	23	vivo	vivo	FW
cord-312001-8p7scli8	365	24	interferon	interferon	NN
cord-312001-8p7scli8	365	25	response	response	NN
cord-312001-8p7scli8	365	26	to	to	IN
cord-312001-8p7scli8	365	27	Listeria	Listeria	NNP
cord-312001-8p7scli8	365	28	monocytogenes	monocytogenes	NNP
cord-312001-8p7scli8	365	29	and	and	CC
cord-312001-8p7scli8	365	30	cyclic	cyclic	JJ
cord-312001-8p7scli8	365	31	dinucleotides	dinucleotide	NNS
cord-312001-8p7scli8	366	1	Cyclic	cyclic	JJ
cord-312001-8p7scli8	366	2	GMP	GMP	NNP
cord-312001-8p7scli8	366	3	-	-	HYPH
cord-312001-8p7scli8	366	4	AMP	AMP	NNP
cord-312001-8p7scli8	366	5	synthase	synthase	NN
cord-312001-8p7scli8	366	6	is	be	VBZ
cord-312001-8p7scli8	366	7	an	an	DT
cord-312001-8p7scli8	366	8	innate	innate	JJ
cord-312001-8p7scli8	366	9	immune	immune	JJ
cord-312001-8p7scli8	366	10	sensor	sensor	NN
cord-312001-8p7scli8	366	11	of	of	IN
cord-312001-8p7scli8	366	12	HIV	HIV	NNP
cord-312001-8p7scli8	366	13	and	and	CC
cord-312001-8p7scli8	366	14	other	other	JJ
cord-312001-8p7scli8	366	15	retroviruses	retrovirus	NNS
cord-312001-8p7scli8	367	1	Pivotal	pivotal	JJ
cord-312001-8p7scli8	367	2	roles	role	NNS
cord-312001-8p7scli8	367	3	of	of	IN
cord-312001-8p7scli8	367	4	cGAS	cgas	NN
cord-312001-8p7scli8	367	5	-	-	HYPH
cord-312001-8p7scli8	367	6	cGAMP	cgamp	NN
cord-312001-8p7scli8	367	7	signaling	signal	VBG
cord-312001-8p7scli8	367	8	in	in	IN
cord-312001-8p7scli8	367	9	antiviral	antiviral	JJ
cord-312001-8p7scli8	367	10	defense	defense	NN
cord-312001-8p7scli8	367	11	and	and	CC
cord-312001-8p7scli8	367	12	immune	immune	JJ
cord-312001-8p7scli8	367	13	adjuvant	adjuvant	JJ
cord-312001-8p7scli8	367	14	effects	effect	NNS
cord-312001-8p7scli8	367	15	cGAS	cgas	NN
cord-312001-8p7scli8	367	16	senses	sense	NNS
cord-312001-8p7scli8	367	17	long	long	RB
cord-312001-8p7scli8	367	18	and	and	CC
cord-312001-8p7scli8	367	19	HMGB	HMGB	NNP
cord-312001-8p7scli8	367	20	/	/	SYM
cord-312001-8p7scli8	367	21	TFAM	TFAM	NNP
cord-312001-8p7scli8	367	22	-	-	HYPH
cord-312001-8p7scli8	367	23	bound	bind	VBN
cord-312001-8p7scli8	367	24	U	u	NN
cord-312001-8p7scli8	367	25	-	-	HYPH
cord-312001-8p7scli8	367	26	turn	turn	NN
cord-312001-8p7scli8	367	27	DNA	dna	NN
cord-312001-8p7scli8	367	28	by	by	IN
cord-312001-8p7scli8	367	29	forming	form	VBG
cord-312001-8p7scli8	367	30	protein	protein	NN
cord-312001-8p7scli8	367	31	-	-	HYPH
cord-312001-8p7scli8	367	32	DNA	dna	NN
cord-312001-8p7scli8	367	33	ladders	ladder	NNS
cord-312001-8p7scli8	368	1	Cyclic	cyclic	JJ
cord-312001-8p7scli8	369	1	GMP	GMP	NNP
cord-312001-8p7scli8	369	2	-	-	HYPH
cord-312001-8p7scli8	369	3	AMP	AMP	NNP
cord-312001-8p7scli8	369	4	synthase	synthase	NN
cord-312001-8p7scli8	369	5	is	be	VBZ
cord-312001-8p7scli8	369	6	activated	activate	VBN
cord-312001-8p7scli8	369	7	by	by	IN
cord-312001-8p7scli8	369	8	double	double	RB
cord-312001-8p7scli8	369	9	-	-	HYPH
cord-312001-8p7scli8	369	10	stranded	strand	VBN
cord-312001-8p7scli8	369	11	DNA	dna	NN
cord-312001-8p7scli8	369	12	-	-	HYPH
cord-312001-8p7scli8	369	13	induced	induce	VBN
cord-312001-8p7scli8	369	14	oligomerization	oligomerization	NN
cord-312001-8p7scli8	369	15	cGAS	cgas	NN
cord-312001-8p7scli8	369	16	produces	produce	VBZ
cord-312001-8p7scli8	369	17	a	a	DT
cord-312001-8p7scli8	369	18	2	2	CD
cord-312001-8p7scli8	369	19	-5	-5	CD
cord-312001-8p7scli8	369	20	-linked	-linked	JJ
cord-312001-8p7scli8	369	21	cyclic	cyclic	JJ
cord-312001-8p7scli8	369	22	dinucleotide	dinucleotide	NN
cord-312001-8p7scli8	369	23	second	second	JJ
cord-312001-8p7scli8	369	24	messenger	messenger	NN
cord-312001-8p7scli8	369	25	that	that	WDT
cord-312001-8p7scli8	369	26	activates	activate	VBZ
cord-312001-8p7scli8	369	27	STING	STING	NNP
cord-312001-8p7scli8	369	28	Cyclic	cyclic	JJ
cord-312001-8p7scli8	369	29	GMP	GMP	NNP
cord-312001-8p7scli8	369	30	-	-	HYPH
cord-312001-8p7scli8	369	31	AMP	AMP	NNP
cord-312001-8p7scli8	369	32	containing	contain	VBG
cord-312001-8p7scli8	369	33	mixed	mixed	JJ
cord-312001-8p7scli8	369	34	phosphodiester	phosphodiester	NN
cord-312001-8p7scli8	369	35	linkages	linkage	NNS
cord-312001-8p7scli8	370	1	is	be	VBZ
cord-312001-8p7scli8	370	2	an	an	DT
cord-312001-8p7scli8	370	3	endogenous	endogenous	JJ
cord-312001-8p7scli8	370	4	high	high	JJ
cord-312001-8p7scli8	370	5	-	-	HYPH
cord-312001-8p7scli8	370	6	affinity	affinity	NN
cord-312001-8p7scli8	370	7	ligand	ligand	NN
cord-312001-8p7scli8	370	8	for	for	IN
cord-312001-8p7scli8	370	9	STING	sting	NN
cord-312001-8p7scli8	370	10	Viruses	virus	NNS
cord-312001-8p7scli8	370	11	transfer	transfer	VBP
cord-312001-8p7scli8	370	12	the	the	DT
cord-312001-8p7scli8	370	13	antiviral	antiviral	JJ
cord-312001-8p7scli8	370	14	second	second	JJ
cord-312001-8p7scli8	370	15	messenger	messenger	NN
cord-312001-8p7scli8	370	16	cGAMP	cGAMP	NNP
cord-312001-8p7scli8	370	17	between	between	IN
cord-312001-8p7scli8	370	18	cells	cell	NNS
cord-312001-8p7scli8	370	19	Transmission	transmission	NN
cord-312001-8p7scli8	370	20	of	of	IN
cord-312001-8p7scli8	370	21	innate	innate	JJ
cord-312001-8p7scli8	370	22	immune	immune	JJ
cord-312001-8p7scli8	370	23	signaling	signaling	NN
cord-312001-8p7scli8	370	24	by	by	IN
cord-312001-8p7scli8	370	25	packaging	packaging	NN
cord-312001-8p7scli8	370	26	of	of	IN
cord-312001-8p7scli8	370	27	cGAMP	cGAMP	NNS
cord-312001-8p7scli8	370	28	in	in	IN
cord-312001-8p7scli8	370	29	viral	viral	JJ
cord-312001-8p7scli8	370	30	particles	particle	NNS
cord-312001-8p7scli8	370	31	Structure	structure	NN
cord-312001-8p7scli8	370	32	-	-	HYPH
cord-312001-8p7scli8	370	33	function	function	NN
cord-312001-8p7scli8	370	34	analysis	analysis	NN
cord-312001-8p7scli8	370	35	of	of	IN
cord-312001-8p7scli8	370	36	STING	sting	NN
cord-312001-8p7scli8	370	37	activation	activation	NN
cord-312001-8p7scli8	370	38	by	by	IN
cord-312001-8p7scli8	370	39	c[G(2	c[G(2	NNP
cord-312001-8p7scli8	370	40	,	,	,
cord-312001-8p7scli8	370	41	5	5	CD
cord-312001-8p7scli8	370	42	)	)	-RRB-
cord-312001-8p7scli8	370	43	pA(3	pA(3	NNP
cord-312001-8p7scli8	370	44	,	,	,
cord-312001-8p7scli8	370	45	5	5	CD
cord-312001-8p7scli8	370	46	)	)	-RRB-
cord-312001-8p7scli8	370	47	p	p	NN
cord-312001-8p7scli8	370	48	]	]	-RRB-
cord-312001-8p7scli8	370	49	and	and	CC
cord-312001-8p7scli8	370	50	targeting	target	VBG
cord-312001-8p7scli8	370	51	by	by	IN
cord-312001-8p7scli8	370	52	antiviral	antiviral	JJ
cord-312001-8p7scli8	370	53	DMXAA	DMXAA	NNP
cord-312001-8p7scli8	370	54	Atg9a	Atg9a	NNP
cord-312001-8p7scli8	370	55	controls	control	VBZ
cord-312001-8p7scli8	370	56	dsDNA	dsdna	RB
cord-312001-8p7scli8	370	57	-	-	HYPH
cord-312001-8p7scli8	370	58	driven	drive	VBN
cord-312001-8p7scli8	370	59	dynamic	dynamic	JJ
cord-312001-8p7scli8	370	60	translocation	translocation	NN
cord-312001-8p7scli8	370	61	of	of	IN
cord-312001-8p7scli8	370	62	STING	sting	NN
cord-312001-8p7scli8	370	63	and	and	CC
cord-312001-8p7scli8	370	64	the	the	DT
cord-312001-8p7scli8	370	65	innate	innate	JJ
cord-312001-8p7scli8	370	66	immune	immune	JJ
cord-312001-8p7scli8	370	67	response	response	NN
cord-312001-8p7scli8	371	1	Phosphorylation	phosphorylation	NN
cord-312001-8p7scli8	371	2	of	of	IN
cord-312001-8p7scli8	371	3	innate	innate	JJ
cord-312001-8p7scli8	371	4	immune	immune	JJ
cord-312001-8p7scli8	371	5	adaptor	adaptor	NN
cord-312001-8p7scli8	371	6	proteins	protein	NNS
cord-312001-8p7scli8	371	7	MAVS	mavs	RB
cord-312001-8p7scli8	371	8	,	,	,
cord-312001-8p7scli8	371	9	STING	sting	NN
cord-312001-8p7scli8	371	10	,	,	,
cord-312001-8p7scli8	371	11	and	and	CC
cord-312001-8p7scli8	371	12	TRIF	TRIF	NNP
cord-312001-8p7scli8	371	13	induces	induce	VBZ
cord-312001-8p7scli8	371	14	IRF3	IRF3	NNP
cord-312001-8p7scli8	371	15	activation	activation	NN
cord-312001-8p7scli8	371	16	Activation	activation	NN
cord-312001-8p7scli8	371	17	of	of	IN
cord-312001-8p7scli8	371	18	STAT6	stat6	NN
cord-312001-8p7scli8	371	19	by	by	IN
cord-312001-8p7scli8	371	20	STING	STING	NNP
cord-312001-8p7scli8	371	21	is	be	VBZ
cord-312001-8p7scli8	371	22	critical	critical	JJ
cord-312001-8p7scli8	371	23	for	for	IN
cord-312001-8p7scli8	371	24	antiviral	antiviral	JJ
cord-312001-8p7scli8	371	25	innate	innate	JJ
cord-312001-8p7scli8	371	26	immunity	immunity	NN
cord-312001-8p7scli8	372	1	Cytosolic	Cytosolic	NNP
cord-312001-8p7scli8	372	2	-	-	HYPH
cord-312001-8p7scli8	372	3	DNA	dna	NN
cord-312001-8p7scli8	372	4	-	-	HYPH
cord-312001-8p7scli8	372	5	mediated	mediate	VBN
cord-312001-8p7scli8	372	6	,	,	,
cord-312001-8p7scli8	372	7	STING	sting	NN
cord-312001-8p7scli8	372	8	-	-	HYPH
cord-312001-8p7scli8	372	9	dependent	dependent	JJ
cord-312001-8p7scli8	372	10	proinflammatory	proinflammatory	JJ
cord-312001-8p7scli8	372	11	gene	gene	NN
cord-312001-8p7scli8	372	12	induction	induction	NN
cord-312001-8p7scli8	372	13	necessitates	necessitate	VBZ
cord-312001-8p7scli8	372	14	canonical	canonical	JJ
cord-312001-8p7scli8	372	15	NF	NF	NNP
cord-312001-8p7scli8	372	16	-	-	HYPH
cord-312001-8p7scli8	372	17	kappaB	kappaB	NNP
cord-312001-8p7scli8	372	18	activation	activation	NN
cord-312001-8p7scli8	372	19	through	through	IN
cord-312001-8p7scli8	372	20	TBK1	TBK1	NNP
cord-312001-8p7scli8	372	21	Activation	Activation	NNP
cord-312001-8p7scli8	372	22	of	of	IN
cord-312001-8p7scli8	372	23	autophagy	autophagy	NN
cord-312001-8p7scli8	372	24	by	by	IN
cord-312001-8p7scli8	372	25	alpha	alpha	NN
cord-312001-8p7scli8	372	26	-	-	HYPH
cord-312001-8p7scli8	372	27	herpesviruses	herpesviruse	NNS
cord-312001-8p7scli8	372	28	in	in	IN
cord-312001-8p7scli8	372	29	myeloid	myeloid	JJ
cord-312001-8p7scli8	372	30	cells	cell	NNS
cord-312001-8p7scli8	372	31	is	be	VBZ
cord-312001-8p7scli8	372	32	mediated	mediate	VBN
cord-312001-8p7scli8	372	33	by	by	IN
cord-312001-8p7scli8	372	34	cytoplasmic	cytoplasmic	JJ
cord-312001-8p7scli8	372	35	viral	viral	JJ
cord-312001-8p7scli8	372	36	DNA	dna	NN
cord-312001-8p7scli8	372	37	through	through	IN
cord-312001-8p7scli8	372	38	a	a	DT
cord-312001-8p7scli8	372	39	mechanism	mechanism	NN
cord-312001-8p7scli8	372	40	dependent	dependent	JJ
cord-312001-8p7scli8	372	41	on	on	IN
cord-312001-8p7scli8	372	42	stimulator	stimulator	NN
cord-312001-8p7scli8	372	43	of	of	IN
cord-312001-8p7scli8	372	44	IFN	IFN	NNP
cord-312001-8p7scli8	372	45	genes	genes	NNPS
cord-312001-8p7scli8	372	46	Establishment	Establishment	NNP
cord-312001-8p7scli8	372	47	of	of	IN
cord-312001-8p7scli8	372	48	dorsal	dorsal	JJ
cord-312001-8p7scli8	372	49	-	-	HYPH
cord-312001-8p7scli8	372	50	ventral	ventral	JJ
cord-312001-8p7scli8	372	51	polarity	polarity	NN
cord-312001-8p7scli8	372	52	in	in	IN
cord-312001-8p7scli8	372	53	the	the	DT
cord-312001-8p7scli8	372	54	Drosophila	drosophila	JJ
cord-312001-8p7scli8	372	55	embryo	embryo	NN
cord-312001-8p7scli8	372	56	:	:	:
cord-312001-8p7scli8	373	1	The	the	DT
cord-312001-8p7scli8	373	2	induction	induction	NN
cord-312001-8p7scli8	373	3	of	of	IN
cord-312001-8p7scli8	373	4	polarity	polarity	NN
cord-312001-8p7scli8	373	5	by	by	IN
cord-312001-8p7scli8	373	6	the	the	DT
cord-312001-8p7scli8	373	7	Toll	Toll	NNP
cord-312001-8p7scli8	373	8	gene	gene	NN
cord-312001-8p7scli8	373	9	product	product	NN
cord-312001-8p7scli8	373	10	Signals	signal	NNS
cord-312001-8p7scli8	373	11	from	from	IN
cord-312001-8p7scli8	373	12	the	the	DT
cord-312001-8p7scli8	373	13	IL-1	IL-1	NNP
cord-312001-8p7scli8	373	14	receptor	receptor	NN
cord-312001-8p7scli8	373	15	homolog	homolog	NN
cord-312001-8p7scli8	373	16	,	,	,
cord-312001-8p7scli8	373	17	Toll	Toll	NNP
cord-312001-8p7scli8	373	18	,	,	,
cord-312001-8p7scli8	373	19	can	can	MD
cord-312001-8p7scli8	373	20	activate	activate	VB
cord-312001-8p7scli8	373	21	an	an	DT
cord-312001-8p7scli8	373	22	immune	immune	JJ
cord-312001-8p7scli8	373	23	response	response	NN
cord-312001-8p7scli8	373	24	in	in	IN
cord-312001-8p7scli8	373	25	a	a	DT
cord-312001-8p7scli8	373	26	Drosophila	Drosophila	NNP
cord-312001-8p7scli8	373	27	hemocyte	hemocyte	NN
cord-312001-8p7scli8	373	28	cell	cell	NN
cord-312001-8p7scli8	373	29	line	line	NN
cord-312001-8p7scli8	374	1	The	the	DT
cord-312001-8p7scli8	374	2	dorsoventral	dorsoventral	JJ
cord-312001-8p7scli8	374	3	regulatory	regulatory	JJ
cord-312001-8p7scli8	374	4	gene	gene	NN
cord-312001-8p7scli8	374	5	cassette	cassette	NN
cord-312001-8p7scli8	374	6	spatzle	spatzle	NNP
cord-312001-8p7scli8	374	7	/	/	SYM
cord-312001-8p7scli8	374	8	Toll	toll	NN
cord-312001-8p7scli8	374	9	/	/	SYM
cord-312001-8p7scli8	374	10	cactus	cactus	NN
cord-312001-8p7scli8	374	11	controls	control	VBZ
cord-312001-8p7scli8	374	12	the	the	DT
cord-312001-8p7scli8	374	13	potent	potent	JJ
cord-312001-8p7scli8	374	14	antifungal	antifungal	JJ
cord-312001-8p7scli8	374	15	response	response	NN
cord-312001-8p7scli8	374	16	in	in	IN
cord-312001-8p7scli8	374	17	Drosophila	drosophila	JJ
cord-312001-8p7scli8	374	18	adults	adult	NNS
cord-312001-8p7scli8	374	19	Chromosomal	chromosomal	JJ
cord-312001-8p7scli8	374	20	localization	localization	NN
cord-312001-8p7scli8	374	21	of	of	IN
cord-312001-8p7scli8	374	22	TIL	TIL	NNP
cord-312001-8p7scli8	374	23	,	,	,
cord-312001-8p7scli8	374	24	a	a	DT
cord-312001-8p7scli8	374	25	gene	gene	NN
cord-312001-8p7scli8	374	26	encoding	encode	VBG
cord-312001-8p7scli8	374	27	a	a	DT
cord-312001-8p7scli8	374	28	protein	protein	NN
cord-312001-8p7scli8	374	29	related	relate	VBN
cord-312001-8p7scli8	374	30	to	to	IN
cord-312001-8p7scli8	374	31	the	the	DT
cord-312001-8p7scli8	374	32	Drosophila	drosophila	JJ
cord-312001-8p7scli8	374	33	transmembrane	transmembrane	NN
cord-312001-8p7scli8	374	34	receptor	receptor	NN
cord-312001-8p7scli8	374	35	Toll	Toll	NNP
cord-312001-8p7scli8	374	36	,	,	,
cord-312001-8p7scli8	374	37	to	to	IN
cord-312001-8p7scli8	374	38	human	human	JJ
cord-312001-8p7scli8	374	39	chromosome	chromosome	NN
cord-312001-8p7scli8	375	1	4p14	4p14	CD
cord-312001-8p7scli8	375	2	Prediction	Prediction	NNP
cord-312001-8p7scli8	375	3	of	of	IN
cord-312001-8p7scli8	375	4	the	the	DT
cord-312001-8p7scli8	375	5	coding	coding	NN
cord-312001-8p7scli8	375	6	sequences	sequence	NNS
cord-312001-8p7scli8	375	7	of	of	IN
cord-312001-8p7scli8	375	8	unidentified	unidentified	JJ
cord-312001-8p7scli8	375	9	human	human	JJ
cord-312001-8p7scli8	375	10	genes	gene	NNS
cord-312001-8p7scli8	375	11	.	.	.
cord-312001-8p7scli8	376	1	I.	I.	NNP
cord-312001-8p7scli8	377	1	The	the	DT
cord-312001-8p7scli8	377	2	coding	code	VBG
cord-312001-8p7scli8	377	3	sequences	sequence	NNS
cord-312001-8p7scli8	377	4	of	of	IN
cord-312001-8p7scli8	377	5	40	40	CD
cord-312001-8p7scli8	377	6	new	new	JJ
cord-312001-8p7scli8	377	7	genes	gene	NNS
cord-312001-8p7scli8	377	8	(	(	-LRB-
cord-312001-8p7scli8	377	9	KIAA0001-KIAA0040	KIAA0001-KIAA0040	NNP
cord-312001-8p7scli8	377	10	)	)	-RRB-
cord-312001-8p7scli8	377	11	deduced	deduce	VBN
cord-312001-8p7scli8	377	12	by	by	IN
cord-312001-8p7scli8	377	13	analysis	analysis	NN
cord-312001-8p7scli8	377	14	of	of	IN
cord-312001-8p7scli8	377	15	randomly	randomly	RB
cord-312001-8p7scli8	377	16	sampled	sample	VBN
cord-312001-8p7scli8	377	17	cDNA	cdna	NN
cord-312001-8p7scli8	377	18	clones	clone	NNS
cord-312001-8p7scli8	377	19	from	from	IN
cord-312001-8p7scli8	377	20	human	human	JJ
cord-312001-8p7scli8	377	21	immature	immature	JJ
cord-312001-8p7scli8	377	22	myeloid	myeloid	JJ
cord-312001-8p7scli8	377	23	cell	cell	NN
cord-312001-8p7scli8	377	24	line	line	NN
cord-312001-8p7scli8	377	25	KG-1	KG-1	NNP
cord-312001-8p7scli8	377	26	Defective	defective	JJ
cord-312001-8p7scli8	377	27	LPS	lp	NNS
cord-312001-8p7scli8	377	28	signaling	signal	VBG
cord-312001-8p7scli8	377	29	in	in	IN
cord-312001-8p7scli8	377	30	C3H	c3h	NN
cord-312001-8p7scli8	377	31	/	/	SYM
cord-312001-8p7scli8	377	32	HeJ	hej	NN
cord-312001-8p7scli8	377	33	and	and	CC
cord-312001-8p7scli8	377	34	C57BL/10ScCr	c57bl/10sccr	JJ
cord-312001-8p7scli8	377	35	mice	mouse	NNS
cord-312001-8p7scli8	377	36	:	:	:
cord-312001-8p7scli8	378	1	Mutations	mutation	NNS
cord-312001-8p7scli8	378	2	in	in	IN
cord-312001-8p7scli8	378	3	Tlr4	Tlr4	NNP
cord-312001-8p7scli8	378	4	gene	gene	NN
cord-312001-8p7scli8	379	1	The	the	DT
cord-312001-8p7scli8	379	2	role	role	NN
cord-312001-8p7scli8	379	3	of	of	IN
cord-312001-8p7scli8	379	4	pattern	pattern	NN
cord-312001-8p7scli8	379	5	-	-	HYPH
cord-312001-8p7scli8	379	6	recognition	recognition	NN
cord-312001-8p7scli8	379	7	receptors	receptor	NNS
cord-312001-8p7scli8	379	8	in	in	IN
cord-312001-8p7scli8	379	9	innate	innate	JJ
cord-312001-8p7scli8	379	10	immunity	immunity	NN
cord-312001-8p7scli8	379	11	:	:	:
cord-312001-8p7scli8	379	12	Update	update	NN
cord-312001-8p7scli8	379	13	on	on	IN
cord-312001-8p7scli8	379	14	Toll	Toll	NNP
cord-312001-8p7scli8	379	15	-	-	HYPH
cord-312001-8p7scli8	379	16	like	like	JJ
cord-312001-8p7scli8	379	17	receptors	receptor	NNS
cord-312001-8p7scli8	379	18	Evolutionary	evolutionary	JJ
cord-312001-8p7scli8	379	19	origins	origin	NNS
cord-312001-8p7scli8	379	20	of	of	IN
cord-312001-8p7scli8	379	21	Toll	toll	NN
cord-312001-8p7scli8	379	22	-	-	HYPH
cord-312001-8p7scli8	379	23	like	like	JJ
cord-312001-8p7scli8	379	24	receptor	receptor	NN
cord-312001-8p7scli8	379	25	signaling	signal	VBG
cord-312001-8p7scli8	379	26	Innate	innate	JJ
cord-312001-8p7scli8	379	27	immunity	immunity	NN
cord-312001-8p7scli8	379	28	in	in	IN
cord-312001-8p7scli8	379	29	the	the	DT
cord-312001-8p7scli8	379	30	simplest	simple	JJS
cord-312001-8p7scli8	379	31	animals	animal	NNS
cord-312001-8p7scli8	379	32	-	-	:
cord-312001-8p7scli8	379	33	Placozoans	Placozoans	NNPS
cord-312001-8p7scli8	379	34	Sea	Sea	NNP
cord-312001-8p7scli8	379	35	anemone	anemone	NN
cord-312001-8p7scli8	379	36	model	model	NN
cord-312001-8p7scli8	379	37	has	have	VBZ
cord-312001-8p7scli8	379	38	a	a	DT
cord-312001-8p7scli8	379	39	single	single	JJ
cord-312001-8p7scli8	379	40	Toll	toll	NN
cord-312001-8p7scli8	379	41	-	-	HYPH
cord-312001-8p7scli8	379	42	like	like	JJ
cord-312001-8p7scli8	379	43	receptor	receptor	NN
cord-312001-8p7scli8	379	44	that	that	WDT
cord-312001-8p7scli8	379	45	can	can	MD
cord-312001-8p7scli8	379	46	function	function	VB
cord-312001-8p7scli8	379	47	in	in	IN
cord-312001-8p7scli8	379	48	pathogen	pathogen	NN
cord-312001-8p7scli8	379	49	detection	detection	NN
cord-312001-8p7scli8	379	50	,	,	,
cord-312001-8p7scli8	379	51	NF	NF	NNP
cord-312001-8p7scli8	379	52	-	-	HYPH
cord-312001-8p7scli8	379	53	kappaB	kappaB	NNP
cord-312001-8p7scli8	379	54	signal	signal	NN
cord-312001-8p7scli8	379	55	transduction	transduction	NN
cord-312001-8p7scli8	379	56	,	,	,
cord-312001-8p7scli8	379	57	and	and	CC
cord-312001-8p7scli8	379	58	development	development	NN
cord-312001-8p7scli8	380	1	The	the	DT
cord-312001-8p7scli8	380	2	innate	innate	JJ
cord-312001-8p7scli8	380	3	immune	immune	JJ
cord-312001-8p7scli8	380	4	repertoire	repertoire	NN
cord-312001-8p7scli8	380	5	in	in	IN
cord-312001-8p7scli8	380	6	cnidaria	cnidaria	NNP
cord-312001-8p7scli8	380	7	-	-	:
cord-312001-8p7scli8	380	8	Ancestral	ancestral	JJ
cord-312001-8p7scli8	380	9	complexity	complexity	NN
cord-312001-8p7scli8	380	10	and	and	CC
cord-312001-8p7scli8	380	11	stochastic	stochastic	JJ
cord-312001-8p7scli8	380	12	gene	gene	NN
cord-312001-8p7scli8	380	13	loss	loss	NN
cord-312001-8p7scli8	380	14	Differential	Differential	NNP
cord-312001-8p7scli8	380	15	and	and	CC
cord-312001-8p7scli8	380	16	convergent	convergent	JJ
cord-312001-8p7scli8	380	17	utilization	utilization	NN
cord-312001-8p7scli8	380	18	of	of	IN
cord-312001-8p7scli8	380	19	autophagy	autophagy	NN
cord-312001-8p7scli8	380	20	components	component	NNS
cord-312001-8p7scli8	380	21	by	by	IN
cord-312001-8p7scli8	380	22	positive	positive	JJ
cord-312001-8p7scli8	380	23	-	-	HYPH
cord-312001-8p7scli8	380	24	strand	strand	NN
cord-312001-8p7scli8	380	25	RNA	RNA	NNP
cord-312001-8p7scli8	380	26	viruses	virus	NNS
cord-312001-8p7scli8	381	1	A	a	DT
cord-312001-8p7scli8	381	2	conserved	conserve	VBN
cord-312001-8p7scli8	381	3	Toll	toll	NN
cord-312001-8p7scli8	381	4	-	-	HYPH
cord-312001-8p7scli8	381	5	like	like	JJ
cord-312001-8p7scli8	381	6	receptor	receptor	NN
cord-312001-8p7scli8	381	7	-	-	HYPH
cord-312001-8p7scli8	381	8	to	to	IN
cord-312001-8p7scli8	381	9	-	-	HYPH
cord-312001-8p7scli8	381	10	NF	nf	NN
cord-312001-8p7scli8	381	11	-	-	HYPH
cord-312001-8p7scli8	381	12	kappaB	kappaB	NNP
cord-312001-8p7scli8	381	13	signaling	signal	VBG
cord-312001-8p7scli8	381	14	pathway	pathway	NN
cord-312001-8p7scli8	381	15	in	in	IN
cord-312001-8p7scli8	381	16	the	the	DT
cord-312001-8p7scli8	381	17	endangered	endanger	VBN
cord-312001-8p7scli8	381	18	coral	coral	NN
cord-312001-8p7scli8	381	19	Orbicella	Orbicella	NNP
cord-312001-8p7scli8	381	20	faveolata	faveolata	NN
cord-312001-8p7scli8	381	21	Genomic	genomic	JJ
cord-312001-8p7scli8	381	22	insights	insight	NNS
cord-312001-8p7scli8	381	23	into	into	IN
cord-312001-8p7scli8	381	24	the	the	DT
cord-312001-8p7scli8	381	25	immune	immune	JJ
cord-312001-8p7scli8	381	26	system	system	NN
cord-312001-8p7scli8	381	27	of	of	IN
cord-312001-8p7scli8	381	28	the	the	DT
cord-312001-8p7scli8	381	29	sea	sea	NN
cord-312001-8p7scli8	381	30	urchin	urchin	NN
cord-312001-8p7scli8	381	31	Massively	massively	RB
cord-312001-8p7scli8	381	32	parallel	parallel	JJ
cord-312001-8p7scli8	381	33	RNA	RNA	NNP
cord-312001-8p7scli8	381	34	sequencing	sequencing	NN
cord-312001-8p7scli8	381	35	identifies	identify	VBZ
cord-312001-8p7scli8	381	36	a	a	DT
cord-312001-8p7scli8	381	37	complex	complex	JJ
cord-312001-8p7scli8	381	38	immune	immune	JJ
cord-312001-8p7scli8	381	39	gene	gene	NN
cord-312001-8p7scli8	381	40	repertoire	repertoire	NN
cord-312001-8p7scli8	381	41	in	in	IN
cord-312001-8p7scli8	381	42	the	the	DT
cord-312001-8p7scli8	381	43	lophotrochozoan	lophotrochozoan	NNP
cord-312001-8p7scli8	381	44	Mytilus	Mytilus	NNP
cord-312001-8p7scli8	381	45	edulis	edulis	NN
cord-312001-8p7scli8	381	46	Massive	massive	JJ
cord-312001-8p7scli8	381	47	expansion	expansion	NN
cord-312001-8p7scli8	381	48	and	and	CC
cord-312001-8p7scli8	381	49	functional	functional	JJ
cord-312001-8p7scli8	381	50	divergence	divergence	NN
cord-312001-8p7scli8	381	51	of	of	IN
cord-312001-8p7scli8	381	52	innate	innate	JJ
cord-312001-8p7scli8	381	53	immune	immune	JJ
cord-312001-8p7scli8	381	54	genes	gene	NNS
cord-312001-8p7scli8	381	55	in	in	IN
cord-312001-8p7scli8	381	56	a	a	DT
cord-312001-8p7scli8	381	57	protostome	protostome	NN
cord-312001-8p7scli8	382	1	Teleost	Teleost	NNP
cord-312001-8p7scli8	382	2	TLR22	TLR22	NNP
cord-312001-8p7scli8	382	3	recognizes	recognize	VBZ
cord-312001-8p7scli8	382	4	RNA	RNA	NNP
cord-312001-8p7scli8	382	5	duplex	duplex	NN
cord-312001-8p7scli8	382	6	to	to	TO
cord-312001-8p7scli8	382	7	induce	induce	VB
cord-312001-8p7scli8	382	8	IFN	IFN	NNP
cord-312001-8p7scli8	382	9	and	and	CC
cord-312001-8p7scli8	382	10	protect	protect	VB
cord-312001-8p7scli8	382	11	cells	cell	NNS
cord-312001-8p7scli8	382	12	from	from	IN
cord-312001-8p7scli8	382	13	birnaviruses	birnaviruse	NNS
cord-312001-8p7scli8	383	1	Adaptive	adaptive	JJ
cord-312001-8p7scli8	383	2	evolution	evolution	NN
cord-312001-8p7scli8	383	3	of	of	IN
cord-312001-8p7scli8	383	4	virus	virus	NN
cord-312001-8p7scli8	383	5	-	-	HYPH
cord-312001-8p7scli8	383	6	sensing	sense	VBG
cord-312001-8p7scli8	383	7	toll	toll	NN
cord-312001-8p7scli8	383	8	-	-	HYPH
cord-312001-8p7scli8	383	9	like	like	JJ
cord-312001-8p7scli8	383	10	receptor	receptor	NN
cord-312001-8p7scli8	383	11	8	8	CD
cord-312001-8p7scli8	383	12	in	in	IN
cord-312001-8p7scli8	383	13	bats	bat	NNS
cord-312001-8p7scli8	384	1	The	the	DT
cord-312001-8p7scli8	384	2	evolution	evolution	NN
cord-312001-8p7scli8	384	3	of	of	IN
cord-312001-8p7scli8	384	4	bat	bat	NN
cord-312001-8p7scli8	384	5	nucleic	nucleic	JJ
cord-312001-8p7scli8	384	6	acid	acid	NN
cord-312001-8p7scli8	384	7	-	-	HYPH
cord-312001-8p7scli8	384	8	sensing	sense	VBG
cord-312001-8p7scli8	384	9	Toll	toll	NN
cord-312001-8p7scli8	384	10	-	-	HYPH
cord-312001-8p7scli8	384	11	like	like	JJ
cord-312001-8p7scli8	384	12	receptors	receptor	NNS
cord-312001-8p7scli8	384	13	Immune	immune	VBP
cord-312001-8p7scli8	384	14	system	system	NN
cord-312001-8p7scli8	384	15	modulation	modulation	NN
cord-312001-8p7scli8	384	16	and	and	CC
cord-312001-8p7scli8	384	17	viral	viral	JJ
cord-312001-8p7scli8	384	18	persistence	persistence	NN
cord-312001-8p7scli8	384	19	in	in	IN
cord-312001-8p7scli8	384	20	bats	bat	NNS
cord-312001-8p7scli8	384	21	:	:	:
cord-312001-8p7scli8	385	1	Understanding	understand	VBG
cord-312001-8p7scli8	385	2	viral	viral	JJ
cord-312001-8p7scli8	385	3	spillover	spillover	NN
cord-312001-8p7scli8	385	4	Origin	origin	NN
cord-312001-8p7scli8	385	5	and	and	CC
cord-312001-8p7scli8	385	6	evolution	evolution	NN
cord-312001-8p7scli8	385	7	of	of	IN
cord-312001-8p7scli8	385	8	the	the	DT
cord-312001-8p7scli8	385	9	RIG	rig	NN
cord-312001-8p7scli8	386	1	-I	-I	NFP
cord-312001-8p7scli8	386	2	like	like	IN
cord-312001-8p7scli8	386	3	RNA	RNA	NNP
cord-312001-8p7scli8	386	4	helicase	helicase	NN
cord-312001-8p7scli8	386	5	gene	gene	NN
cord-312001-8p7scli8	386	6	family	family	NN
cord-312001-8p7scli8	386	7	Characterization	characterization	NN
cord-312001-8p7scli8	386	8	of	of	IN
cord-312001-8p7scli8	386	9	the	the	DT
cord-312001-8p7scli8	386	10	mollusc	mollusc	NNP
cord-312001-8p7scli8	386	11	RIG	RIG	NNP
cord-312001-8p7scli8	386	12	-	-	:
cord-312001-8p7scli8	386	13	I	I	NNP
cord-312001-8p7scli8	386	14	/	/	SYM
cord-312001-8p7scli8	386	15	MAVS	MAVS	NNP
cord-312001-8p7scli8	386	16	pathway	pathway	NNP
cord-312001-8p7scli8	387	1	reveals	reveal	VBZ
cord-312001-8p7scli8	387	2	an	an	DT
cord-312001-8p7scli8	387	3	archaic	archaic	JJ
cord-312001-8p7scli8	387	4	antiviral	antiviral	JJ
cord-312001-8p7scli8	387	5	signalling	signalling	NN
cord-312001-8p7scli8	387	6	framework	framework	NN
cord-312001-8p7scli8	387	7	in	in	IN
cord-312001-8p7scli8	387	8	invertebrates	invertebrate	NNS
cord-312001-8p7scli8	387	9	Retinoic	retinoic	JJ
cord-312001-8p7scli8	387	10	acid	acid	NN
cord-312001-8p7scli8	387	11	-	-	HYPH
cord-312001-8p7scli8	387	12	inducible	inducible	JJ
cord-312001-8p7scli8	387	13	gene	gene	NN
cord-312001-8p7scli8	387	14	I	i	NN
cord-312001-8p7scli8	387	15	(	(	-LRB-
cord-312001-8p7scli8	387	16	RIG	RIG	NNP
cord-312001-8p7scli8	387	17	-	-	HYPH
cord-312001-8p7scli8	387	18	I)-like	I)-like	NNP
cord-312001-8p7scli8	387	19	receptors	receptor	NNS
cord-312001-8p7scli8	387	20	(	(	-LRB-
cord-312001-8p7scli8	387	21	RLRs	rlr	NNS
cord-312001-8p7scli8	387	22	)	)	-RRB-
cord-312001-8p7scli8	387	23	in	in	IN
cord-312001-8p7scli8	387	24	fish	fish	NN
cord-312001-8p7scli8	387	25	:	:	:
cord-312001-8p7scli8	387	26	Current	current	JJ
cord-312001-8p7scli8	387	27	knowledge	knowledge	NN
cord-312001-8p7scli8	387	28	and	and	CC
cord-312001-8p7scli8	387	29	future	future	JJ
cord-312001-8p7scli8	387	30	perspectives	perspective	NNS
cord-312001-8p7scli8	388	1	Chicken	chicken	NN
cord-312001-8p7scli8	388	2	cells	cell	NNS
cord-312001-8p7scli8	388	3	sense	sense	VBP
cord-312001-8p7scli8	388	4	influenza	influenza	NN
cord-312001-8p7scli8	388	5	A	a	DT
cord-312001-8p7scli8	388	6	virus	virus	NN
cord-312001-8p7scli8	388	7	infection	infection	NN
cord-312001-8p7scli8	388	8	through	through	IN
cord-312001-8p7scli8	388	9	MDA5	MDA5	NNP
cord-312001-8p7scli8	388	10	and	and	CC
cord-312001-8p7scli8	388	11	CARDIF	CARDIF	NNP
cord-312001-8p7scli8	388	12	signaling	signal	VBG
cord-312001-8p7scli8	388	13	involving	involve	VBG
cord-312001-8p7scli8	388	14	LGP2	LGP2	NNP
cord-312001-8p7scli8	388	15	Association	Association	NNP
cord-312001-8p7scli8	388	16	of	of	IN
cord-312001-8p7scli8	388	17	RIG	RIG	NNP
cord-312001-8p7scli8	388	18	-	-	:
cord-312001-8p7scli8	388	19	I	-PRON-	PRP
cord-312001-8p7scli8	388	20	with	with	IN
cord-312001-8p7scli8	388	21	innate	innate	JJ
cord-312001-8p7scli8	388	22	immunity	immunity	NN
cord-312001-8p7scli8	388	23	of	of	IN
cord-312001-8p7scli8	388	24	ducks	duck	NNS
cord-312001-8p7scli8	388	25	to	to	IN
cord-312001-8p7scli8	388	26	influenza	influenza	NN
cord-312001-8p7scli8	388	27	Genome	Genome	NNP
cord-312001-8p7scli8	388	28	of	of	IN
cord-312001-8p7scli8	388	29	the	the	DT
cord-312001-8p7scli8	388	30	Chinese	chinese	JJ
cord-312001-8p7scli8	388	31	tree	tree	NN
cord-312001-8p7scli8	388	32	shrew	shrew	NN
cord-312001-8p7scli8	388	33	Loss	loss	NN
cord-312001-8p7scli8	388	34	of	of	IN
cord-312001-8p7scli8	388	35	RIG	rig	NN
cord-312001-8p7scli8	389	1	-I	-i	WDT
cord-312001-8p7scli8	389	2	leads	lead	VBZ
cord-312001-8p7scli8	389	3	to	to	IN
cord-312001-8p7scli8	389	4	a	a	DT
cord-312001-8p7scli8	389	5	functional	functional	JJ
cord-312001-8p7scli8	389	6	replacement	replacement	NN
cord-312001-8p7scli8	389	7	with	with	IN
cord-312001-8p7scli8	389	8	MDA5	MDA5	NNP
cord-312001-8p7scli8	389	9	in	in	IN
cord-312001-8p7scli8	389	10	the	the	DT
cord-312001-8p7scli8	389	11	Chinese	chinese	JJ
cord-312001-8p7scli8	389	12	tree	tree	NN
cord-312001-8p7scli8	389	13	shrew	shrew	NN
cord-312001-8p7scli8	390	1	The	the	DT
cord-312001-8p7scli8	390	2	kinase	kinase	NN
cord-312001-8p7scli8	390	3	IKKbeta	ikkbeta	NN
cord-312001-8p7scli8	390	4	regulates	regulate	VBZ
cord-312001-8p7scli8	390	5	a	a	DT
cord-312001-8p7scli8	390	6	STING	sting	NN
cord-312001-8p7scli8	390	7	-	-	HYPH
cord-312001-8p7scli8	390	8	and	and	CC
cord-312001-8p7scli8	390	9	NF	nf	NN
cord-312001-8p7scli8	390	10	-	-	HYPH
cord-312001-8p7scli8	390	11	kappaB	kappaB	NNP
cord-312001-8p7scli8	390	12	-	-	HYPH
cord-312001-8p7scli8	390	13	dependent	dependent	JJ
cord-312001-8p7scli8	390	14	antiviral	antiviral	JJ
cord-312001-8p7scli8	390	15	response	response	NN
cord-312001-8p7scli8	390	16	pathway	pathway	NN
cord-312001-8p7scli8	390	17	in	in	IN
cord-312001-8p7scli8	390	18	Drosophila	Drosophila	NNP
cord-312001-8p7scli8	391	1	The	the	DT
cord-312001-8p7scli8	391	2	Jak	Jak	NNP
cord-312001-8p7scli8	391	3	-	-	HYPH
cord-312001-8p7scli8	391	4	STAT	STAT	NNP
cord-312001-8p7scli8	391	5	signaling	signal	VBG
cord-312001-8p7scli8	391	6	pathway	pathway	NN
cord-312001-8p7scli8	391	7	is	be	VBZ
cord-312001-8p7scli8	391	8	required	require	VBN
cord-312001-8p7scli8	391	9	but	but	CC
cord-312001-8p7scli8	391	10	not	not	RB
cord-312001-8p7scli8	391	11	sufficient	sufficient	JJ
cord-312001-8p7scli8	391	12	for	for	IN
cord-312001-8p7scli8	391	13	the	the	DT
cord-312001-8p7scli8	391	14	antiviral	antiviral	JJ
cord-312001-8p7scli8	391	15	response	response	NN
cord-312001-8p7scli8	391	16	of	of	IN
cord-312001-8p7scli8	391	17	drosophila	drosophila	NN
cord-312001-8p7scli8	391	18	The	the	DT
cord-312001-8p7scli8	391	19	RNA	RNA	NNP
cord-312001-8p7scli8	391	20	silencing	silencing	NN
cord-312001-8p7scli8	391	21	endonuclease	endonuclease	NN
cord-312001-8p7scli8	391	22	Argonaute	Argonaute	NNP
cord-312001-8p7scli8	391	23	2	2	CD
cord-312001-8p7scli8	392	1	mediates	mediate	VBZ
cord-312001-8p7scli8	392	2	specific	specific	JJ
cord-312001-8p7scli8	392	3	antiviral	antiviral	JJ
cord-312001-8p7scli8	392	4	immunity	immunity	NN
cord-312001-8p7scli8	392	5	in	in	IN
cord-312001-8p7scli8	392	6	Drosophila	Drosophila	NNP
cord-312001-8p7scli8	392	7	melanogaster	melanogaster	NN
cord-312001-8p7scli8	392	8	Essential	essential	JJ
cord-312001-8p7scli8	392	9	function	function	NN
cord-312001-8p7scli8	392	10	in	in	IN
cord-312001-8p7scli8	392	11	vivo	vivo	NN
cord-312001-8p7scli8	392	12	for	for	IN
cord-312001-8p7scli8	392	13	Dicer-2	Dicer-2	NNP
cord-312001-8p7scli8	392	14	in	in	IN
cord-312001-8p7scli8	392	15	host	host	NN
cord-312001-8p7scli8	392	16	defense	defense	NN
cord-312001-8p7scli8	392	17	against	against	IN
cord-312001-8p7scli8	392	18	RNA	RNA	NNP
cord-312001-8p7scli8	392	19	viruses	virus	NNS
cord-312001-8p7scli8	392	20	in	in	IN
cord-312001-8p7scli8	392	21	drosophila	drosophila	NN
cord-312001-8p7scli8	392	22	Sensing	Sensing	NNP
cord-312001-8p7scli8	392	23	viral	viral	JJ
cord-312001-8p7scli8	392	24	RNAs	rna	NNS
cord-312001-8p7scli8	392	25	by	by	IN
cord-312001-8p7scli8	392	26	Dicer	Dicer	NNP
cord-312001-8p7scli8	392	27	/	/	SYM
cord-312001-8p7scli8	392	28	RIG	rig	NN
cord-312001-8p7scli8	393	1	-I	-I	NFP
cord-312001-8p7scli8	393	2	like	like	IN
cord-312001-8p7scli8	393	3	ATPases	atpase	NNS
cord-312001-8p7scli8	394	1	across	across	IN
cord-312001-8p7scli8	394	2	species	specie	NNS
cord-312001-8p7scli8	395	1	The	the	DT
cord-312001-8p7scli8	395	2	DExD	DExD	NNS
cord-312001-8p7scli8	395	3	/	/	SYM
cord-312001-8p7scli8	395	4	H	h	NN
cord-312001-8p7scli8	395	5	-	-	HYPH
cord-312001-8p7scli8	395	6	box	box	NN
cord-312001-8p7scli8	395	7	helicase	helicase	NN
cord-312001-8p7scli8	395	8	Dicer-2	Dicer-2	NNP
cord-312001-8p7scli8	395	9	mediates	mediate	VBZ
cord-312001-8p7scli8	395	10	the	the	DT
cord-312001-8p7scli8	395	11	induction	induction	NN
cord-312001-8p7scli8	395	12	of	of	IN
cord-312001-8p7scli8	395	13	antiviral	antiviral	JJ
cord-312001-8p7scli8	395	14	activity	activity	NN
cord-312001-8p7scli8	395	15	in	in	IN
cord-312001-8p7scli8	395	16	drosophila	drosophila	NN
cord-312001-8p7scli8	395	17	Secreted	secrete	VBN
cord-312001-8p7scli8	395	18	Vago	Vago	NNP
cord-312001-8p7scli8	395	19	restricts	restrict	VBZ
cord-312001-8p7scli8	395	20	West	West	NNP
cord-312001-8p7scli8	395	21	Nile	Nile	NNP
cord-312001-8p7scli8	395	22	virus	virus	NN
cord-312001-8p7scli8	395	23	infection	infection	NN
cord-312001-8p7scli8	395	24	in	in	IN
cord-312001-8p7scli8	395	25	Culex	Culex	NNP
cord-312001-8p7scli8	395	26	mosquito	mosquito	NN
cord-312001-8p7scli8	395	27	cells	cell	NNS
cord-312001-8p7scli8	395	28	by	by	IN
cord-312001-8p7scli8	395	29	activating	activate	VBG
cord-312001-8p7scli8	395	30	the	the	DT
cord-312001-8p7scli8	395	31	Jak	Jak	NNP
cord-312001-8p7scli8	395	32	-	-	HYPH
cord-312001-8p7scli8	395	33	STAT	STAT	NNP
cord-312001-8p7scli8	395	34	pathway	pathway	NN
cord-312001-8p7scli8	395	35	Dicer-2-dependent	Dicer-2-dependent	NNP
cord-312001-8p7scli8	395	36	activation	activation	NN
cord-312001-8p7scli8	395	37	of	of	IN
cord-312001-8p7scli8	395	38	Culex	Culex	NNP
cord-312001-8p7scli8	395	39	Vago	Vago	NNP
cord-312001-8p7scli8	395	40	occurs	occur	VBZ
cord-312001-8p7scli8	395	41	via	via	IN
cord-312001-8p7scli8	395	42	the	the	DT
cord-312001-8p7scli8	395	43	TRAF	TRAF	NNP
cord-312001-8p7scli8	395	44	-	-	HYPH
cord-312001-8p7scli8	395	45	Rel2	Rel2	NNP
cord-312001-8p7scli8	395	46	signaling	signal	VBG
cord-312001-8p7scli8	395	47	pathway	pathway	NN
cord-312001-8p7scli8	395	48	Nucleic	nucleic	CD
cord-312001-8p7scli8	395	49	acid	acid	NN
cord-312001-8p7scli8	395	50	sensing	sensing	NN
cord-312001-8p7scli8	395	51	in	in	IN
cord-312001-8p7scli8	395	52	invertebrate	invertebrate	JJ
cord-312001-8p7scli8	395	53	antiviral	antiviral	JJ
cord-312001-8p7scli8	395	54	immunity	immunity	NN
cord-312001-8p7scli8	396	1	The	the	DT
cord-312001-8p7scli8	396	2	RIG	rig	NN
cord-312001-8p7scli8	396	3	-	-	:
cord-312001-8p7scli8	396	4	I	-PRON-	PRP
cord-312001-8p7scli8	396	5	ATPase	ATPase	NNP
cord-312001-8p7scli8	396	6	core	core	NN
cord-312001-8p7scli8	396	7	has	have	VBZ
cord-312001-8p7scli8	396	8	evolved	evolve	VBN
cord-312001-8p7scli8	396	9	a	a	DT
cord-312001-8p7scli8	396	10	functional	functional	JJ
cord-312001-8p7scli8	396	11	requirement	requirement	NN
cord-312001-8p7scli8	396	12	for	for	IN
cord-312001-8p7scli8	396	13	allosteric	allosteric	JJ
cord-312001-8p7scli8	396	14	stabilization	stabilization	NN
cord-312001-8p7scli8	396	15	by	by	IN
cord-312001-8p7scli8	396	16	the	the	DT
cord-312001-8p7scli8	396	17	Pincer	Pincer	NNP
cord-312001-8p7scli8	396	18	domain	domain	NN
cord-312001-8p7scli8	397	1	The	the	DT
cord-312001-8p7scli8	397	2	selective	selective	JJ
cord-312001-8p7scli8	397	3	footprints	footprint	NNS
cord-312001-8p7scli8	397	4	of	of	IN
cord-312001-8p7scli8	397	5	viral	viral	JJ
cord-312001-8p7scli8	397	6	pressures	pressure	NNS
cord-312001-8p7scli8	397	7	at	at	IN
cord-312001-8p7scli8	397	8	the	the	DT
cord-312001-8p7scli8	397	9	human	human	JJ
cord-312001-8p7scli8	397	10	RIG	rig	NN
cord-312001-8p7scli8	397	11	-	-	HYPH
cord-312001-8p7scli8	397	12	I	I	NNP
cord-312001-8p7scli8	397	13	-	-	HYPH
cord-312001-8p7scli8	397	14	like	like	JJ
cord-312001-8p7scli8	397	15	receptor	receptor	NN
cord-312001-8p7scli8	397	16	family	family	NN
cord-312001-8p7scli8	397	17	Evolution	evolution	NN
cord-312001-8p7scli8	397	18	and	and	CC
cord-312001-8p7scli8	397	19	functional	functional	JJ
cord-312001-8p7scli8	397	20	impact	impact	NN
cord-312001-8p7scli8	397	21	of	of	IN
cord-312001-8p7scli8	397	22	rare	rare	JJ
cord-312001-8p7scli8	397	23	coding	coding	NN
cord-312001-8p7scli8	397	24	variation	variation	NN
cord-312001-8p7scli8	397	25	from	from	IN
cord-312001-8p7scli8	397	26	deep	deep	JJ
cord-312001-8p7scli8	397	27	sequencing	sequencing	NN
cord-312001-8p7scli8	397	28	of	of	IN
cord-312001-8p7scli8	397	29	human	human	JJ
cord-312001-8p7scli8	397	30	exomes	exome	NNS
cord-312001-8p7scli8	398	1	Cyclic	cyclic	JJ
cord-312001-8p7scli8	398	2	di	di	NN
cord-312001-8p7scli8	398	3	-	-	HYPH
cord-312001-8p7scli8	398	4	nucleotide	nucleotide	JJ
cord-312001-8p7scli8	398	5	signaling	signaling	NN
cord-312001-8p7scli8	398	6	enters	enter	VBZ
cord-312001-8p7scli8	398	7	the	the	DT
cord-312001-8p7scli8	398	8	eukaryote	eukaryote	NN
cord-312001-8p7scli8	398	9	domain	domain	NN
cord-312001-8p7scli8	398	10	Evolutionary	evolutionary	JJ
cord-312001-8p7scli8	398	11	origins	origin	NNS
cord-312001-8p7scli8	398	12	of	of	IN
cord-312001-8p7scli8	398	13	cGAS	cgas	NN
cord-312001-8p7scli8	398	14	-	-	HYPH
cord-312001-8p7scli8	398	15	STING	sting	NN
cord-312001-8p7scli8	398	16	signaling	signal	VBG
cord-312001-8p7scli8	398	17	Toll	toll	NN
cord-312001-8p7scli8	399	1	signaling	signal	VBG
cord-312001-8p7scli8	399	2	:	:	:
cord-312001-8p7scli8	400	1	The	the	DT
cord-312001-8p7scli8	400	2	TIReless	TIReless	NNP
cord-312001-8p7scli8	400	3	quest	quest	VBP
cord-312001-8p7scli8	400	4	for	for	IN
cord-312001-8p7scli8	400	5	specificity	specificity	NN
cord-312001-8p7scli8	400	6	Analysis	Analysis	NNP
cord-312001-8p7scli8	400	7	of	of	IN
cord-312001-8p7scli8	400	8	Drosophila	drosophila	JJ
cord-312001-8p7scli8	400	9	STING	STING	NNP
cord-312001-8p7scli8	400	10	reveals	reveal	VBZ
cord-312001-8p7scli8	400	11	an	an	DT
cord-312001-8p7scli8	400	12	evolutionarily	evolutionarily	RB
cord-312001-8p7scli8	400	13	conserved	conserve	VBN
cord-312001-8p7scli8	400	14	antimicrobial	antimicrobial	JJ
cord-312001-8p7scli8	400	15	function	function	NN
cord-312001-8p7scli8	400	16	Modular	modular	JJ
cord-312001-8p7scli8	400	17	architecture	architecture	NN
cord-312001-8p7scli8	400	18	of	of	IN
cord-312001-8p7scli8	400	19	the	the	DT
cord-312001-8p7scli8	400	20	STING	STING	NNP
cord-312001-8p7scli8	400	21	C	c	NN
cord-312001-8p7scli8	400	22	-	-	HYPH
cord-312001-8p7scli8	400	23	terminal	terminal	NN
cord-312001-8p7scli8	400	24	tail	tail	NN
cord-312001-8p7scli8	400	25	allows	allow	VBZ
cord-312001-8p7scli8	400	26	interferon	interferon	NN
cord-312001-8p7scli8	400	27	and	and	CC
cord-312001-8p7scli8	400	28	NF	NF	NNP
cord-312001-8p7scli8	400	29	-	-	HYPH
cord-312001-8p7scli8	400	30	kappaB	kappaB	NNP
cord-312001-8p7scli8	400	31	signaling	signal	VBG
cord-312001-8p7scli8	400	32	adaptation	adaptation	NN
cord-312001-8p7scli8	401	1	Dampened	dampened	JJ
cord-312001-8p7scli8	401	2	STING	sting	NN
cord-312001-8p7scli8	401	3	-	-	HYPH
cord-312001-8p7scli8	401	4	dependent	dependent	JJ
cord-312001-8p7scli8	401	5	interferon	interferon	NN
cord-312001-8p7scli8	401	6	activation	activation	NN
cord-312001-8p7scli8	401	7	in	in	IN
cord-312001-8p7scli8	401	8	bats	bat	NNS
cord-312001-8p7scli8	401	9	Structure	Structure	NNP
cord-312001-8p7scli8	401	10	of	of	IN
cord-312001-8p7scli8	401	11	human	human	JJ
cord-312001-8p7scli8	401	12	cGAS	cgas	NN
cord-312001-8p7scli8	401	13	reveals	reveal	VBZ
cord-312001-8p7scli8	401	14	a	a	DT
cord-312001-8p7scli8	401	15	conserved	conserved	JJ
cord-312001-8p7scli8	401	16	family	family	NN
cord-312001-8p7scli8	401	17	of	of	IN
cord-312001-8p7scli8	401	18	second	second	JJ
cord-312001-8p7scli8	401	19	-	-	HYPH
cord-312001-8p7scli8	401	20	messenger	messenger	NN
cord-312001-8p7scli8	401	21	enzymes	enzyme	NNS
cord-312001-8p7scli8	401	22	in	in	IN
cord-312001-8p7scli8	401	23	innate	innate	JJ
cord-312001-8p7scli8	401	24	immunity	immunity	NN
cord-312001-8p7scli8	401	25	]	]	-RRB-
cord-312001-8p7scli8	401	26	is	be	VBZ
cord-312001-8p7scli8	401	27	the	the	DT
cord-312001-8p7scli8	401	28	metazoan	metazoan	NN
cord-312001-8p7scli8	401	29	second	second	JJ
cord-312001-8p7scli8	401	30	messenger	messenger	NN
cord-312001-8p7scli8	401	31	produced	produce	VBN
cord-312001-8p7scli8	401	32	by	by	IN
cord-312001-8p7scli8	401	33	DNA	DNA	NNP
cord-312001-8p7scli8	401	34	-	-	HYPH
cord-312001-8p7scli8	401	35	activated	activate	VBN
cord-312001-8p7scli8	401	36	cyclic	cyclic	JJ
cord-312001-8p7scli8	401	37	GMP	GMP	NNP
cord-312001-8p7scli8	401	38	-	-	HYPH
cord-312001-8p7scli8	401	39	AMP	AMP	NNP
cord-312001-8p7scli8	401	40	synthase	synthase	NN
cord-312001-8p7scli8	401	41	Structural	structural	JJ
cord-312001-8p7scli8	401	42	mechanism	mechanism	NN
cord-312001-8p7scli8	401	43	of	of	IN
cord-312001-8p7scli8	401	44	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	401	45	DNA	dna	NN
cord-312001-8p7scli8	401	46	sensing	sensing	NN
cord-312001-8p7scli8	401	47	by	by	IN
cord-312001-8p7scli8	401	48	cGAS	cga	VBG
cord-312001-8p7scli8	401	49	Overlapping	overlapping	JJ
cord-312001-8p7scli8	401	50	patterns	pattern	NNS
cord-312001-8p7scli8	401	51	of	of	IN
cord-312001-8p7scli8	401	52	rapid	rapid	JJ
cord-312001-8p7scli8	401	53	evolution	evolution	NN
cord-312001-8p7scli8	401	54	in	in	IN
cord-312001-8p7scli8	401	55	the	the	DT
cord-312001-8p7scli8	401	56	nucleic	nucleic	JJ
cord-312001-8p7scli8	401	57	acid	acid	NN
cord-312001-8p7scli8	401	58	sensors	sensor	NNS
cord-312001-8p7scli8	401	59	cGAS	cgas	NN
cord-312001-8p7scli8	401	60	and	and	CC
cord-312001-8p7scli8	401	61	OAS1	OAS1	NNP
cord-312001-8p7scli8	401	62	suggest	suggest	VBP
cord-312001-8p7scli8	401	63	a	a	DT
cord-312001-8p7scli8	401	64	common	common	JJ
cord-312001-8p7scli8	401	65	mechanism	mechanism	NN
cord-312001-8p7scli8	401	66	of	of	IN
cord-312001-8p7scli8	401	67	pathogen	pathogen	NN
cord-312001-8p7scli8	401	68	antagonism	antagonism	NN
cord-312001-8p7scli8	401	69	and	and	CC
cord-312001-8p7scli8	401	70	escape	escape	VB
cord-312001-8p7scli8	401	71	The	the	DT
cord-312001-8p7scli8	401	72	discovery	discovery	NN
cord-312001-8p7scli8	401	73	,	,	,
cord-312001-8p7scli8	401	74	mechanisms	mechanism	NNS
cord-312001-8p7scli8	401	75	,	,	,
cord-312001-8p7scli8	401	76	and	and	CC
cord-312001-8p7scli8	401	77	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	401	78	impact	impact	NN
cord-312001-8p7scli8	401	79	of	of	IN
cord-312001-8p7scli8	401	80	anti	anti	JJ
cord-312001-8p7scli8	401	81	-	-	JJ
cord-312001-8p7scli8	401	82	CRISPRs	crisprs	JJ
cord-312001-8p7scli8	401	83	Decoding	Decoding	NNP
cord-312001-8p7scli8	401	84	type	type	NN
cord-312001-8p7scli8	401	85	I	-PRON-	PRP
cord-312001-8p7scli8	401	86	and	and	CC
cord-312001-8p7scli8	401	87	III	III	NNP
cord-312001-8p7scli8	401	88	interferon	interferon	NN
cord-312001-8p7scli8	401	89	signalling	signal	VBG
cord-312001-8p7scli8	401	90	during	during	IN
cord-312001-8p7scli8	401	91	viral	viral	JJ
cord-312001-8p7scli8	401	92	infection	infection	NN
cord-312001-8p7scli8	401	93	Viral	viral	JJ
cord-312001-8p7scli8	401	94	evasion	evasion	NN
cord-312001-8p7scli8	401	95	of	of	IN
cord-312001-8p7scli8	401	96	DNA	dna	NN
cord-312001-8p7scli8	401	97	-	-	HYPH
cord-312001-8p7scli8	401	98	stimulated	stimulate	VBN
cord-312001-8p7scli8	401	99	innate	innate	JJ
cord-312001-8p7scli8	401	100	immune	immune	JJ
cord-312001-8p7scli8	401	101	responses	response	NNS
cord-312001-8p7scli8	401	102	Ten	ten	CD
cord-312001-8p7scli8	401	103	strategies	strategy	NNS
cord-312001-8p7scli8	401	104	of	of	IN
cord-312001-8p7scli8	401	105	interferon	interferon	NN
cord-312001-8p7scli8	401	106	evasion	evasion	NN
cord-312001-8p7scli8	401	107	by	by	IN
cord-312001-8p7scli8	401	108	viruses	virus	NNS
cord-312001-8p7scli8	401	109	Viral	viral	JJ
cord-312001-8p7scli8	401	110	evasion	evasion	NN
cord-312001-8p7scli8	401	111	of	of	IN
cord-312001-8p7scli8	401	112	intracellular	intracellular	JJ
cord-312001-8p7scli8	401	113	DNA	DNA	NNP
cord-312001-8p7scli8	401	114	and	and	CC
cord-312001-8p7scli8	401	115	RNA	RNA	NNP
cord-312001-8p7scli8	401	116	sensing	sense	VBG
cord-312001-8p7scli8	401	117	Viral	viral	JJ
cord-312001-8p7scli8	401	118	evasion	evasion	NN
cord-312001-8p7scli8	401	119	and	and	CC
cord-312001-8p7scli8	401	120	subversion	subversion	NN
cord-312001-8p7scli8	401	121	of	of	IN
cord-312001-8p7scli8	401	122	pattern	pattern	NN
cord-312001-8p7scli8	401	123	-	-	HYPH
cord-312001-8p7scli8	401	124	recognition	recognition	NN
cord-312001-8p7scli8	401	125	receptor	receptor	NN
cord-312001-8p7scli8	401	126	signalling	signal	VBG
cord-312001-8p7scli8	401	127	A46R	A46R	NNPS
cord-312001-8p7scli8	401	128	and	and	CC
cord-312001-8p7scli8	401	129	A52R	a52r	NN
cord-312001-8p7scli8	401	130	from	from	IN
cord-312001-8p7scli8	401	131	vaccinia	vaccinia	NN
cord-312001-8p7scli8	401	132	virus	virus	NN
cord-312001-8p7scli8	401	133	are	be	VBP
cord-312001-8p7scli8	401	134	antagonists	antagonist	NNS
cord-312001-8p7scli8	401	135	of	of	IN
cord-312001-8p7scli8	401	136	host	host	NN
cord-312001-8p7scli8	401	137	IL-1	IL-1	NNP
cord-312001-8p7scli8	401	138	and	and	CC
cord-312001-8p7scli8	401	139	toll	toll	NN
cord-312001-8p7scli8	401	140	-	-	HYPH
cord-312001-8p7scli8	401	141	like	like	JJ
cord-312001-8p7scli8	401	142	receptor	receptor	NN
cord-312001-8p7scli8	401	143	signaling	signal	VBG
cord-312001-8p7scli8	401	144	Vaccinia	Vaccinia	NNP
cord-312001-8p7scli8	401	145	virus	virus	NN
cord-312001-8p7scli8	401	146	protein	protein	NN
cord-312001-8p7scli8	401	147	A46R	A46R	NNPS
cord-312001-8p7scli8	401	148	targets	target	VBZ
cord-312001-8p7scli8	401	149	multiple	multiple	JJ
cord-312001-8p7scli8	401	150	Toll	toll	NN
cord-312001-8p7scli8	401	151	-	-	HYPH
cord-312001-8p7scli8	401	152	like	like	IN
cord-312001-8p7scli8	401	153	-	-	HYPH
cord-312001-8p7scli8	401	154	interleukin-1	interleukin-1	NN
cord-312001-8p7scli8	401	155	receptor	receptor	NN
cord-312001-8p7scli8	401	156	adaptors	adaptor	NNS
cord-312001-8p7scli8	401	157	and	and	CC
cord-312001-8p7scli8	401	158	contributes	contribute	VBZ
cord-312001-8p7scli8	401	159	to	to	IN
cord-312001-8p7scli8	401	160	virulence	virulence	NN
cord-312001-8p7scli8	402	1	The	the	DT
cord-312001-8p7scli8	402	2	HTLV-	HTLV-	NNS
cord-312001-8p7scli8	403	1	I	-PRON-	PRP
cord-312001-8p7scli8	403	2	p30	p30	NNP
cord-312001-8p7scli8	403	3	interferes	interfere	VBZ
cord-312001-8p7scli8	403	4	with	with	IN
cord-312001-8p7scli8	403	5	TLR4	TLR4	NNP
cord-312001-8p7scli8	403	6	signaling	signaling	NN
cord-312001-8p7scli8	403	7	and	and	CC
cord-312001-8p7scli8	403	8	modulates	modulate	VBZ
cord-312001-8p7scli8	403	9	the	the	DT
cord-312001-8p7scli8	403	10	release	release	NN
cord-312001-8p7scli8	403	11	of	of	IN
cord-312001-8p7scli8	403	12	pro	pro	JJ
cord-312001-8p7scli8	403	13	-	-	JJ
cord-312001-8p7scli8	403	14	and	and	CC
cord-312001-8p7scli8	403	15	anti	anti	JJ
cord-312001-8p7scli8	403	16	-	-	JJ
cord-312001-8p7scli8	403	17	inflammatory	inflammatory	JJ
cord-312001-8p7scli8	403	18	cytokines	cytokine	NNS
cord-312001-8p7scli8	403	19	from	from	IN
cord-312001-8p7scli8	403	20	human	human	JJ
cord-312001-8p7scli8	403	21	macrophages	macrophage	NNS
cord-312001-8p7scli8	403	22	Innate	innate	JJ
cord-312001-8p7scli8	403	23	immunity	immunity	NN
cord-312001-8p7scli8	403	24	evasion	evasion	NN
cord-312001-8p7scli8	403	25	by	by	IN
cord-312001-8p7scli8	403	26	enteroviruses	enterovirus	NNS
cord-312001-8p7scli8	403	27	:	:	:
cord-312001-8p7scli8	403	28	Insights	insight	NNS
cord-312001-8p7scli8	403	29	into	into	IN
cord-312001-8p7scli8	403	30	virus	virus	NN
cord-312001-8p7scli8	403	31	-	-	HYPH
cord-312001-8p7scli8	403	32	host	host	NN
cord-312001-8p7scli8	403	33	interaction	interaction	NN
cord-312001-8p7scli8	403	34	Toll	toll	NN
cord-312001-8p7scli8	403	35	-	-	HYPH
cord-312001-8p7scli8	403	36	like	like	JJ
cord-312001-8p7scli8	403	37	receptors	receptor	NNS
cord-312001-8p7scli8	403	38	in	in	IN
cord-312001-8p7scli8	403	39	antiviral	antiviral	JJ
cord-312001-8p7scli8	403	40	innate	innate	JJ
cord-312001-8p7scli8	403	41	immunity	immunity	NN
cord-312001-8p7scli8	404	1	Hepatitis	Hepatitis	NNP
cord-312001-8p7scli8	404	2	C	C	NNP
cord-312001-8p7scli8	404	3	virus	virus	NN
cord-312001-8p7scli8	404	4	protease	protease	NN
cord-312001-8p7scli8	404	5	NS3/4A	ns3/4a	PRP
cord-312001-8p7scli8	404	6	cleaves	cleave	VBZ
cord-312001-8p7scli8	404	7	mitochondrial	mitochondrial	JJ
cord-312001-8p7scli8	404	8	antiviral	antiviral	JJ
cord-312001-8p7scli8	404	9	signaling	signal	VBG
cord-312001-8p7scli8	404	10	protein	protein	NN
cord-312001-8p7scli8	404	11	off	off	IN
cord-312001-8p7scli8	404	12	the	the	DT
cord-312001-8p7scli8	404	13	mitochondria	mitochondrion	NNS
cord-312001-8p7scli8	404	14	to	to	TO
cord-312001-8p7scli8	404	15	evade	evade	VB
cord-312001-8p7scli8	404	16	innate	innate	JJ
cord-312001-8p7scli8	404	17	immunity	immunity	NN
cord-312001-8p7scli8	404	18	The	the	DT
cord-312001-8p7scli8	404	19	coxsackievirus	coxsackievirus	NN
cord-312001-8p7scli8	404	20	B	B	NNP
cord-312001-8p7scli8	404	21	3C	3C	NNP
cord-312001-8p7scli8	404	22	protease	protease	NN
cord-312001-8p7scli8	404	23	cleaves	cleave	VBZ
cord-312001-8p7scli8	404	24	MAVS	MAVS	NNP
cord-312001-8p7scli8	404	25	and	and	CC
cord-312001-8p7scli8	404	26	TRIF	TRIF	NNP
cord-312001-8p7scli8	404	27	to	to	TO
cord-312001-8p7scli8	404	28	attenuate	attenuate	VB
cord-312001-8p7scli8	404	29	host	host	NN
cord-312001-8p7scli8	404	30	type	type	NN
cord-312001-8p7scli8	405	1	I	-PRON-	PRP
cord-312001-8p7scli8	405	2	interferon	interferon	VBD
cord-312001-8p7scli8	405	3	and	and	CC
cord-312001-8p7scli8	405	4	apoptotic	apoptotic	JJ
cord-312001-8p7scli8	405	5	signaling	signal	VBG
cord-312001-8p7scli8	405	6	Disruption	disruption	NN
cord-312001-8p7scli8	405	7	of	of	IN
cord-312001-8p7scli8	405	8	TLR3	TLR3	NNP
cord-312001-8p7scli8	405	9	signaling	signal	VBG
cord-312001-8p7scli8	405	10	due	due	JJ
cord-312001-8p7scli8	405	11	to	to	IN
cord-312001-8p7scli8	405	12	cleavage	cleavage	NN
cord-312001-8p7scli8	405	13	of	of	IN
cord-312001-8p7scli8	405	14	TRIF	TRIF	NNP
cord-312001-8p7scli8	405	15	by	by	IN
cord-312001-8p7scli8	405	16	the	the	DT
cord-312001-8p7scli8	405	17	hepatitis	hepatitis	NN
cord-312001-8p7scli8	405	18	A	A	NNP
cord-312001-8p7scli8	405	19	virus	virus	NN
cord-312001-8p7scli8	405	20	protease	protease	NN
cord-312001-8p7scli8	405	21	-	-	HYPH
cord-312001-8p7scli8	405	22	polymerase	polymerase	NN
cord-312001-8p7scli8	405	23	processing	processing	NN
cord-312001-8p7scli8	405	24	intermediate	intermediate	JJ
cord-312001-8p7scli8	406	1	The	the	DT
cord-312001-8p7scli8	406	2	dengue	dengue	NN
cord-312001-8p7scli8	406	3	virus	virus	NN
cord-312001-8p7scli8	406	4	conceals	conceal	VBZ
cord-312001-8p7scli8	406	5	double	double	RB
cord-312001-8p7scli8	406	6	-	-	HYPH
cord-312001-8p7scli8	406	7	stranded	strand	VBN
cord-312001-8p7scli8	406	8	RNA	RNA	NNP
cord-312001-8p7scli8	406	9	in	in	IN
cord-312001-8p7scli8	406	10	the	the	DT
cord-312001-8p7scli8	406	11	intracellular	intracellular	JJ
cord-312001-8p7scli8	406	12	membrane	membrane	NN
cord-312001-8p7scli8	406	13	to	to	TO
cord-312001-8p7scli8	406	14	escape	escape	VB
cord-312001-8p7scli8	406	15	from	from	IN
cord-312001-8p7scli8	406	16	an	an	DT
cord-312001-8p7scli8	406	17	interferon	interferon	NN
cord-312001-8p7scli8	406	18	response	response	NN
cord-312001-8p7scli8	407	1	Ebola	Ebola	NNP
cord-312001-8p7scli8	407	2	virus	virus	NN
cord-312001-8p7scli8	407	3	VP35	VP35	NNP
cord-312001-8p7scli8	407	4	protein	protein	NN
cord-312001-8p7scli8	407	5	binds	bind	VBZ
cord-312001-8p7scli8	407	6	double	double	RB
cord-312001-8p7scli8	407	7	-	-	HYPH
cord-312001-8p7scli8	407	8	stranded	strand	VBN
cord-312001-8p7scli8	407	9	RNA	RNA	NNP
cord-312001-8p7scli8	407	10	and	and	CC
cord-312001-8p7scli8	407	11	inhibits	inhibit	VBZ
cord-312001-8p7scli8	407	12	alpha	alpha	NN
cord-312001-8p7scli8	407	13	/	/	SYM
cord-312001-8p7scli8	407	14	beta	beta	NN
cord-312001-8p7scli8	407	15	interferon	interferon	NN
cord-312001-8p7scli8	407	16	production	production	NN
cord-312001-8p7scli8	407	17	induced	induce	VBN
cord-312001-8p7scli8	407	18	by	by	IN
cord-312001-8p7scli8	407	19	RIG	rig	NN
cord-312001-8p7scli8	408	1	-I	-i	DT
cord-312001-8p7scli8	408	2	signaling	signal	VBG
cord-312001-8p7scli8	408	3	Structural	structural	JJ
cord-312001-8p7scli8	408	4	basis	basis	NN
cord-312001-8p7scli8	408	5	for	for	IN
cord-312001-8p7scli8	408	6	Marburg	Marburg	NNP
cord-312001-8p7scli8	408	7	virus	virus	NN
cord-312001-8p7scli8	408	8	VP35-mediated	vp35-mediated	CD
cord-312001-8p7scli8	408	9	immune	immune	JJ
cord-312001-8p7scli8	408	10	evasion	evasion	NN
cord-312001-8p7scli8	408	11	mechanisms	mechanism	NNS
cord-312001-8p7scli8	409	1	Sequestration	sequestration	NN
cord-312001-8p7scli8	409	2	by	by	IN
cord-312001-8p7scli8	409	3	IFIT1	ifit1	JJ
cord-312001-8p7scli8	409	4	impairs	impair	VBZ
cord-312001-8p7scli8	409	5	translation	translation	NN
cord-312001-8p7scli8	409	6	of	of	IN
cord-312001-8p7scli8	409	7	2	2	CD
cord-312001-8p7scli8	409	8	O	o	NN
cord-312001-8p7scli8	409	9	-	-	HYPH
cord-312001-8p7scli8	409	10	unmethylated	unmethylate	VBN
cord-312001-8p7scli8	409	11	capped	cap	VBN
cord-312001-8p7scli8	409	12	RNA	RNA	NNP
cord-312001-8p7scli8	409	13	Old	Old	NNP
cord-312001-8p7scli8	409	14	World	World	NNP
cord-312001-8p7scli8	409	15	hantaviruses	hantaviruse	NNS
cord-312001-8p7scli8	409	16	do	do	VBP
cord-312001-8p7scli8	409	17	not	not	RB
cord-312001-8p7scli8	409	18	produce	produce	VB
cord-312001-8p7scli8	409	19	detectable	detectable	JJ
cord-312001-8p7scli8	409	20	amounts	amount	NNS
cord-312001-8p7scli8	409	21	of	of	IN
cord-312001-8p7scli8	409	22	dsRNA	dsrna	NN
cord-312001-8p7scli8	409	23	in	in	IN
cord-312001-8p7scli8	409	24	infected	infected	JJ
cord-312001-8p7scli8	409	25	cells	cell	NNS
cord-312001-8p7scli8	409	26	and	and	CC
cord-312001-8p7scli8	409	27	the	the	DT
cord-312001-8p7scli8	409	28	5	5	CD
cord-312001-8p7scli8	409	29	termini	terminus	NNS
cord-312001-8p7scli8	409	30	of	of	IN
cord-312001-8p7scli8	409	31	their	-PRON-	PRP$
cord-312001-8p7scli8	409	32	genomic	genomic	JJ
cord-312001-8p7scli8	409	33	RNAs	rna	NNS
cord-312001-8p7scli8	409	34	are	be	VBP
cord-312001-8p7scli8	409	35	monophosphorylated	monophosphorylate	VBN
cord-312001-8p7scli8	409	36	Structure	Structure	NNP
cord-312001-8p7scli8	409	37	of	of	IN
cord-312001-8p7scli8	409	38	the	the	DT
cord-312001-8p7scli8	409	39	Lassa	Lassa	NNP
cord-312001-8p7scli8	409	40	virus	virus	NN
cord-312001-8p7scli8	409	41	nucleoprotein	nucleoprotein	NNP
cord-312001-8p7scli8	409	42	reveals	reveal	VBZ
cord-312001-8p7scli8	409	43	a	a	DT
cord-312001-8p7scli8	409	44	dsRNA	dsrna	JJ
cord-312001-8p7scli8	409	45	-	-	HYPH
cord-312001-8p7scli8	409	46	specific	specific	JJ
cord-312001-8p7scli8	409	47	3	3	CD
cord-312001-8p7scli8	409	48	to	to	TO
cord-312001-8p7scli8	409	49	5	5	CD
cord-312001-8p7scli8	409	50	exonuclease	exonuclease	NN
cord-312001-8p7scli8	409	51	activity	activity	NN
cord-312001-8p7scli8	409	52	essential	essential	JJ
cord-312001-8p7scli8	409	53	for	for	IN
cord-312001-8p7scli8	409	54	immune	immune	JJ
cord-312001-8p7scli8	409	55	suppression	suppression	NN
cord-312001-8p7scli8	409	56	RIG	rig	NN
cord-312001-8p7scli8	410	1	-I	-I	NNP
cord-312001-8p7scli8	410	2	is	be	VBZ
cord-312001-8p7scli8	410	3	cleaved	cleave	VBN
cord-312001-8p7scli8	410	4	during	during	IN
cord-312001-8p7scli8	410	5	picornavirus	picornavirus	NNP
cord-312001-8p7scli8	410	6	infection	infection	NN
cord-312001-8p7scli8	410	7	Enterovirus	Enterovirus	NNP
cord-312001-8p7scli8	410	8	2Apro	2apro	CD
cord-312001-8p7scli8	410	9	targets	target	VBZ
cord-312001-8p7scli8	410	10	MDA5	MDA5	NNP
cord-312001-8p7scli8	410	11	and	and	CC
cord-312001-8p7scli8	410	12	MAVS	MAVS	NNPS
cord-312001-8p7scli8	410	13	in	in	IN
cord-312001-8p7scli8	410	14	infected	infected	JJ
cord-312001-8p7scli8	410	15	cells	cell	NNS
cord-312001-8p7scli8	410	16	Cleavage	cleavage	NN
cord-312001-8p7scli8	410	17	of	of	IN
cord-312001-8p7scli8	410	18	IPS-1	IPS-1	NNP
cord-312001-8p7scli8	410	19	in	in	IN
cord-312001-8p7scli8	410	20	cells	cell	NNS
cord-312001-8p7scli8	410	21	infected	infect	VBN
cord-312001-8p7scli8	410	22	with	with	IN
cord-312001-8p7scli8	410	23	human	human	JJ
cord-312001-8p7scli8	410	24	rhinovirus	rhinovirus	NN
cord-312001-8p7scli8	410	25	Disruption	disruption	NN
cord-312001-8p7scli8	410	26	of	of	IN
cord-312001-8p7scli8	410	27	innate	innate	JJ
cord-312001-8p7scli8	410	28	immunity	immunity	NN
cord-312001-8p7scli8	410	29	due	due	IN
cord-312001-8p7scli8	410	30	to	to	IN
cord-312001-8p7scli8	410	31	mitochondrial	mitochondrial	JJ
cord-312001-8p7scli8	410	32	targeting	targeting	NN
cord-312001-8p7scli8	410	33	of	of	IN
cord-312001-8p7scli8	410	34	a	a	DT
cord-312001-8p7scli8	410	35	picornaviral	picornaviral	JJ
cord-312001-8p7scli8	410	36	protease	protease	NN
cord-312001-8p7scli8	410	37	precursor	precursor	NN
cord-312001-8p7scli8	410	38	Mitophagy	Mitophagy	NNP
cord-312001-8p7scli8	410	39	enhances	enhance	VBZ
cord-312001-8p7scli8	410	40	oncolytic	oncolytic	JJ
cord-312001-8p7scli8	410	41	measles	measles	NN
cord-312001-8p7scli8	410	42	virus	virus	NN
cord-312001-8p7scli8	410	43	replication	replication	NN
cord-312001-8p7scli8	410	44	by	by	IN
cord-312001-8p7scli8	410	45	mitigating	mitigate	VBG
cord-312001-8p7scli8	410	46	DDX58	DDX58	NNP
cord-312001-8p7scli8	410	47	/	/	SYM
cord-312001-8p7scli8	410	48	RIG	rig	NN
cord-312001-8p7scli8	410	49	-	-	HYPH
cord-312001-8p7scli8	410	50	I	-PRON-	PRP
cord-312001-8p7scli8	410	51	-	-	HYPH
cord-312001-8p7scli8	410	52	like	like	JJ
cord-312001-8p7scli8	410	53	receptor	receptor	NN
cord-312001-8p7scli8	410	54	signaling	signal	VBG
cord-312001-8p7scli8	410	55	SARS	SARS	NNP
cord-312001-8p7scli8	410	56	-	-	HYPH
cord-312001-8p7scli8	410	57	coronavirus	coronavirus	NN
cord-312001-8p7scli8	410	58	open	open	JJ
cord-312001-8p7scli8	410	59	reading	reading	NN
cord-312001-8p7scli8	411	1	frame-9b	frame-9b	NNP
cord-312001-8p7scli8	411	2	suppresses	suppress	VBZ
cord-312001-8p7scli8	411	3	innate	innate	JJ
cord-312001-8p7scli8	411	4	immunity	immunity	NN
cord-312001-8p7scli8	411	5	by	by	IN
cord-312001-8p7scli8	411	6	targeting	target	VBG
cord-312001-8p7scli8	411	7	mitochondria	mitochondrion	NNS
cord-312001-8p7scli8	411	8	and	and	CC
cord-312001-8p7scli8	411	9	the	the	DT
cord-312001-8p7scli8	411	10	MAVS	MAVS	NNPS
cord-312001-8p7scli8	411	11	/	/	SYM
cord-312001-8p7scli8	411	12	TRAF3	TRAF3	NNP
cord-312001-8p7scli8	411	13	/	/	SYM
cord-312001-8p7scli8	411	14	TRAF6	TRAF6	NNP
cord-312001-8p7scli8	411	15	signalosome	signalosome	NNP
cord-312001-8p7scli8	412	1	Influenza	Influenza	NNP
cord-312001-8p7scli8	412	2	A	a	DT
cord-312001-8p7scli8	412	3	virus	virus	NN
cord-312001-8p7scli8	412	4	NS1	ns1	CD
cord-312001-8p7scli8	412	5	targets	target	VBZ
cord-312001-8p7scli8	412	6	the	the	DT
cord-312001-8p7scli8	412	7	ubiquitin	ubiquitin	NN
cord-312001-8p7scli8	412	8	ligase	ligase	NN
cord-312001-8p7scli8	412	9	TRIM25	TRIM25	NNP
cord-312001-8p7scli8	412	10	to	to	TO
cord-312001-8p7scli8	412	11	evade	evade	VB
cord-312001-8p7scli8	412	12	recognition	recognition	NN
cord-312001-8p7scli8	412	13	by	by	IN
cord-312001-8p7scli8	412	14	the	the	DT
cord-312001-8p7scli8	412	15	host	host	NN
cord-312001-8p7scli8	412	16	viral	viral	JJ
cord-312001-8p7scli8	412	17	RNA	RNA	NNP
cord-312001-8p7scli8	412	18	sensor	sensor	NN
cord-312001-8p7scli8	412	19	RIG	rig	NN
cord-312001-8p7scli8	412	20	-	-	:
cord-312001-8p7scli8	412	21	I	I	NNP
cord-312001-8p7scli8	412	22	Deubiquitinating	Deubiquitinating	NNP
cord-312001-8p7scli8	412	23	and	and	CC
cord-312001-8p7scli8	412	24	interferon	interferon	NN
cord-312001-8p7scli8	412	25	antagonism	antagonism	NN
cord-312001-8p7scli8	412	26	activities	activity	NNS
cord-312001-8p7scli8	412	27	of	of	IN
cord-312001-8p7scli8	412	28	coronavirus	coronavirus	NN
cord-312001-8p7scli8	412	29	papain	papain	NN
cord-312001-8p7scli8	412	30	-	-	HYPH
cord-312001-8p7scli8	412	31	like	like	JJ
cord-312001-8p7scli8	412	32	proteases	protease	NNS
cord-312001-8p7scli8	412	33	Inhibition	inhibition	NN
cord-312001-8p7scli8	412	34	of	of	IN
cord-312001-8p7scli8	412	35	RIG	rig	NN
cord-312001-8p7scli8	413	1	-I	-i	RBS
cord-312001-8p7scli8	413	2	-	-	HYPH
cord-312001-8p7scli8	413	3	mediated	mediate	VBN
cord-312001-8p7scli8	413	4	signaling	signaling	NN
cord-312001-8p7scli8	413	5	by	by	IN
cord-312001-8p7scli8	413	6	Kaposi	Kaposi	NNP
cord-312001-8p7scli8	413	7	's	's	POS
cord-312001-8p7scli8	413	8	sarcoma	sarcoma	NN
cord-312001-8p7scli8	413	9	-	-	HYPH
cord-312001-8p7scli8	413	10	associated	associate	VBN
cord-312001-8p7scli8	413	11	herpesvirus	herpesvirus	NN
cord-312001-8p7scli8	413	12	-	-	HYPH
cord-312001-8p7scli8	413	13	encoded	encode	VBN
cord-312001-8p7scli8	413	14	deubiquitinase	deubiquitinase	NN
cord-312001-8p7scli8	413	15	ORF64	ORF64	NNP
cord-312001-8p7scli8	413	16	Deubiquitinase	Deubiquitinase	NNP
cord-312001-8p7scli8	413	17	function	function	NN
cord-312001-8p7scli8	413	18	of	of	IN
cord-312001-8p7scli8	413	19	arterivirus	arterivirus	NNP
cord-312001-8p7scli8	413	20	papain	papain	NN
cord-312001-8p7scli8	413	21	-	-	HYPH
cord-312001-8p7scli8	413	22	like	like	JJ
cord-312001-8p7scli8	413	23	protease	protease	NN
cord-312001-8p7scli8	413	24	2	2	CD
cord-312001-8p7scli8	413	25	suppresses	suppress	VBZ
cord-312001-8p7scli8	413	26	the	the	DT
cord-312001-8p7scli8	413	27	innate	innate	JJ
cord-312001-8p7scli8	413	28	immune	immune	JJ
cord-312001-8p7scli8	413	29	response	response	NN
cord-312001-8p7scli8	413	30	in	in	IN
cord-312001-8p7scli8	413	31	infected	infected	JJ
cord-312001-8p7scli8	413	32	host	host	NN
cord-312001-8p7scli8	413	33	cells	cell	NNS
cord-312001-8p7scli8	413	34	Antagonism	antagonism	NN
cord-312001-8p7scli8	413	35	of	of	IN
cord-312001-8p7scli8	413	36	the	the	DT
cord-312001-8p7scli8	413	37	phosphatase	phosphatase	NN
cord-312001-8p7scli8	413	38	PP1	PP1	NNP
cord-312001-8p7scli8	413	39	by	by	IN
cord-312001-8p7scli8	413	40	the	the	DT
cord-312001-8p7scli8	413	41	measles	measle	NNS
cord-312001-8p7scli8	413	42	virus	virus	NN
cord-312001-8p7scli8	413	43	V	v	NN
cord-312001-8p7scli8	413	44	protein	protein	NN
cord-312001-8p7scli8	413	45	is	be	VBZ
cord-312001-8p7scli8	413	46	required	require	VBN
cord-312001-8p7scli8	413	47	for	for	IN
cord-312001-8p7scli8	413	48	innate	innate	JJ
cord-312001-8p7scli8	413	49	immune	immune	JJ
cord-312001-8p7scli8	413	50	escape	escape	NN
cord-312001-8p7scli8	413	51	of	of	IN
cord-312001-8p7scli8	413	52	MDA5	MDA5	NNP
cord-312001-8p7scli8	413	53	Measles	Measles	NNP
cord-312001-8p7scli8	413	54	virus	virus	NN
cord-312001-8p7scli8	414	1	suppresses	suppress	VBZ
cord-312001-8p7scli8	414	2	RIG	rig	NN
cord-312001-8p7scli8	414	3	-	-	HYPH
cord-312001-8p7scli8	414	4	I	i	NN
cord-312001-8p7scli8	414	5	-	-	HYPH
cord-312001-8p7scli8	414	6	like	like	JJ
cord-312001-8p7scli8	414	7	receptor	receptor	NN
cord-312001-8p7scli8	414	8	activation	activation	NN
cord-312001-8p7scli8	414	9	in	in	IN
cord-312001-8p7scli8	414	10	dendritic	dendritic	JJ
cord-312001-8p7scli8	414	11	cells	cell	NNS
cord-312001-8p7scli8	414	12	via	via	IN
cord-312001-8p7scli8	414	13	DC	DC	NNP
cord-312001-8p7scli8	414	14	-	-	HYPH
cord-312001-8p7scli8	414	15	SIGN	sign	NN
cord-312001-8p7scli8	414	16	-	-	HYPH
cord-312001-8p7scli8	414	17	mediated	mediate	VBN
cord-312001-8p7scli8	414	18	inhibition	inhibition	NN
cord-312001-8p7scli8	414	19	of	of	IN
cord-312001-8p7scli8	414	20	PP1	PP1	NNP
cord-312001-8p7scli8	414	21	phosphatases	phosphatase	NNS
cord-312001-8p7scli8	415	1	The	the	DT
cord-312001-8p7scli8	415	2	cGAS	cgas	JJ
cord-312001-8p7scli8	415	3	-	-	HYPH
cord-312001-8p7scli8	415	4	STING	sting	NN
cord-312001-8p7scli8	415	5	defense	defense	NN
cord-312001-8p7scli8	415	6	pathway	pathway	NN
cord-312001-8p7scli8	415	7	and	and	CC
cord-312001-8p7scli8	415	8	its	-PRON-	PRP$
cord-312001-8p7scli8	415	9	counteraction	counteraction	NN
cord-312001-8p7scli8	415	10	by	by	IN
cord-312001-8p7scli8	415	11	viruses	virus	NNS
cord-312001-8p7scli8	416	1	Immune	immune	JJ
cord-312001-8p7scli8	416	2	evasion	evasion	NN
cord-312001-8p7scli8	416	3	strategies	strategy	NNS
cord-312001-8p7scli8	416	4	during	during	IN
cord-312001-8p7scli8	416	5	chronic	chronic	JJ
cord-312001-8p7scli8	416	6	hepatitis	hepatitis	NN
cord-312001-8p7scli8	416	7	B	B	NNP
cord-312001-8p7scli8	416	8	and	and	CC
cord-312001-8p7scli8	416	9	C	C	NNP
cord-312001-8p7scli8	416	10	virus	virus	NN
cord-312001-8p7scli8	416	11	infection	infection	NN
cord-312001-8p7scli8	416	12	.	.	.
cord-312001-8p7scli8	417	1	Vaccines	vaccine	NNS
cord-312001-8p7scli8	417	2	(	(	-LRB-
cord-312001-8p7scli8	417	3	Basel	Basel	NNP
cord-312001-8p7scli8	417	4	)	)	-RRB-
cord-312001-8p7scli8	417	5	2017	2017	CD
cord-312001-8p7scli8	417	6	,	,	,
cord-312001-8p7scli8	417	7	5	5	CD
cord-312001-8p7scli8	417	8	,	,	,
cord-312001-8p7scli8	417	9	24	24	CD
cord-312001-8p7scli8	417	10	Hepatitis	Hepatitis	NNP
cord-312001-8p7scli8	417	11	B	B	NNP
cord-312001-8p7scli8	417	12	virus	virus	NN
cord-312001-8p7scli8	417	13	polymerase	polymerase	NN
cord-312001-8p7scli8	417	14	disrupts	disrupt	VBZ
cord-312001-8p7scli8	417	15	K63-linked	k63-linke	VBN
cord-312001-8p7scli8	417	16	ubiquitination	ubiquitination	NN
cord-312001-8p7scli8	417	17	of	of	IN
cord-312001-8p7scli8	417	18	STING	sting	NN
cord-312001-8p7scli8	417	19	to	to	TO
cord-312001-8p7scli8	417	20	block	block	VB
cord-312001-8p7scli8	417	21	innate	innate	JJ
cord-312001-8p7scli8	417	22	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	417	23	DNA	dna	NN
cord-312001-8p7scli8	417	24	-	-	HYPH
cord-312001-8p7scli8	417	25	sensing	sense	VBG
cord-312001-8p7scli8	417	26	pathways	pathway	NNS
cord-312001-8p7scli8	417	27	Hepatitis	Hepatitis	NNP
cord-312001-8p7scli8	417	28	B	B	NNP
cord-312001-8p7scli8	417	29	virus	virus	NN
cord-312001-8p7scli8	417	30	evasion	evasion	NN
cord-312001-8p7scli8	417	31	from	from	IN
cord-312001-8p7scli8	417	32	cyclic	cyclic	JJ
cord-312001-8p7scli8	417	33	guanosine	guanosine	NN
cord-312001-8p7scli8	417	34	monophosphate	monophosphate	NN
cord-312001-8p7scli8	417	35	-	-	HYPH
cord-312001-8p7scli8	417	36	adenosine	adenosine	NN
cord-312001-8p7scli8	417	37	monophosphate	monophosphate	NN
cord-312001-8p7scli8	417	38	synthase	synthase	NN
cord-312001-8p7scli8	417	39	sensing	sensing	NN
cord-312001-8p7scli8	417	40	in	in	IN
cord-312001-8p7scli8	417	41	human	human	JJ
cord-312001-8p7scli8	417	42	hepatocytes	hepatocyte	NNS
cord-312001-8p7scli8	417	43	Inhibition	Inhibition	NNP
cord-312001-8p7scli8	417	44	of	of	IN
cord-312001-8p7scli8	417	45	cGAS	cgas	JJ
cord-312001-8p7scli8	417	46	DNA	dna	NN
cord-312001-8p7scli8	417	47	sensing	sensing	NN
cord-312001-8p7scli8	417	48	by	by	IN
cord-312001-8p7scli8	417	49	a	a	DT
cord-312001-8p7scli8	417	50	herpesvirus	herpesvirus	NN
cord-312001-8p7scli8	417	51	virion	virion	NN
cord-312001-8p7scli8	417	52	protein	protein	NN
cord-312001-8p7scli8	417	53	Cytoplasmic	Cytoplasmic	NNP
cord-312001-8p7scli8	417	54	isoforms	isoform	NNS
cord-312001-8p7scli8	417	55	of	of	IN
cord-312001-8p7scli8	417	56	Kaposi	Kaposi	NNP
cord-312001-8p7scli8	417	57	sarcoma	sarcoma	NN
cord-312001-8p7scli8	417	58	herpesvirus	herpesvirus	NN
cord-312001-8p7scli8	417	59	LANA	LANA	NNP
cord-312001-8p7scli8	417	60	recruit	recruit	VB
cord-312001-8p7scli8	417	61	and	and	CC
cord-312001-8p7scli8	417	62	antagonize	antagonize	VB
cord-312001-8p7scli8	417	63	the	the	DT
cord-312001-8p7scli8	417	64	innate	innate	JJ
cord-312001-8p7scli8	417	65	immune	immune	JJ
cord-312001-8p7scli8	417	66	DNA	dna	NN
cord-312001-8p7scli8	417	67	sensor	sensor	NN
cord-312001-8p7scli8	417	68	cGAS	cga	VBG
cord-312001-8p7scli8	417	69	Modulation	modulation	NN
cord-312001-8p7scli8	417	70	of	of	IN
cord-312001-8p7scli8	417	71	the	the	DT
cord-312001-8p7scli8	417	72	cGAS	cgas	JJ
cord-312001-8p7scli8	417	73	-	-	HYPH
cord-312001-8p7scli8	417	74	STING	sting	NN
cord-312001-8p7scli8	417	75	DNA	dna	NN
cord-312001-8p7scli8	417	76	sensing	sensing	NN
cord-312001-8p7scli8	417	77	pathway	pathway	NN
cord-312001-8p7scli8	417	78	by	by	IN
cord-312001-8p7scli8	417	79	gammaherpesviruses	gammaherpesviruses	NNP
cord-312001-8p7scli8	417	80	DENV	DENV	NNP
cord-312001-8p7scli8	418	1	inhibits	inhibit	VBZ
cord-312001-8p7scli8	418	2	type	type	NN
cord-312001-8p7scli8	419	1	I	-PRON-	PRP
cord-312001-8p7scli8	419	2	IFN	IFN	NNP
cord-312001-8p7scli8	419	3	production	production	NN
cord-312001-8p7scli8	419	4	in	in	IN
cord-312001-8p7scli8	419	5	infected	infected	JJ
cord-312001-8p7scli8	419	6	cells	cell	NNS
cord-312001-8p7scli8	419	7	by	by	IN
cord-312001-8p7scli8	419	8	cleaving	cleave	VBG
cord-312001-8p7scli8	419	9	human	human	JJ
cord-312001-8p7scli8	419	10	STING	STING	NNP
cord-312001-8p7scli8	419	11	Dengue	Dengue	NNP
cord-312001-8p7scli8	419	12	virus	virus	NN
cord-312001-8p7scli8	419	13	targets	target	VBZ
cord-312001-8p7scli8	419	14	the	the	DT
cord-312001-8p7scli8	419	15	adaptor	adaptor	NN
cord-312001-8p7scli8	419	16	protein	protein	NN
cord-312001-8p7scli8	419	17	MITA	MITA	NNP
cord-312001-8p7scli8	419	18	to	to	TO
cord-312001-8p7scli8	419	19	subvert	subvert	VB
cord-312001-8p7scli8	419	20	host	host	NN
cord-312001-8p7scli8	419	21	innate	innate	JJ
cord-312001-8p7scli8	419	22	immunity	immunity	NN
cord-312001-8p7scli8	419	23	Evolutionary	evolutionary	JJ
cord-312001-8p7scli8	419	24	conflicts	conflict	NNS
cord-312001-8p7scli8	419	25	between	between	IN
cord-312001-8p7scli8	419	26	viruses	virus	NNS
cord-312001-8p7scli8	419	27	and	and	CC
cord-312001-8p7scli8	419	28	restriction	restriction	NN
cord-312001-8p7scli8	419	29	factors	factor	NNS
cord-312001-8p7scli8	419	30	shape	shape	VBP
cord-312001-8p7scli8	419	31	immunity	immunity	NN
cord-312001-8p7scli8	420	1	The	the	DT
cord-312001-8p7scli8	420	2	evolutionary	evolutionary	JJ
cord-312001-8p7scli8	420	3	conundrum	conundrum	NN
cord-312001-8p7scli8	420	4	of	of	IN
cord-312001-8p7scli8	420	5	pathogen	pathogen	NN
cord-312001-8p7scli8	420	6	mimicry	mimicry	NN
cord-312001-8p7scli8	420	7	Enhanced	enhance	VBN
cord-312001-8p7scli8	420	8	influenza	influenza	NN
cord-312001-8p7scli8	420	9	virus	virus	NN
cord-312001-8p7scli8	420	10	-	-	HYPH
cord-312001-8p7scli8	420	11	like	like	JJ
cord-312001-8p7scli8	420	12	particle	particle	NN
cord-312001-8p7scli8	420	13	vaccination	vaccination	NN
cord-312001-8p7scli8	420	14	with	with	IN
cord-312001-8p7scli8	420	15	a	a	DT
cord-312001-8p7scli8	420	16	structurally	structurally	RB
cord-312001-8p7scli8	420	17	optimized	optimize	VBN
cord-312001-8p7scli8	420	18	RIG	rig	NN
cord-312001-8p7scli8	420	19	-	-	:
cord-312001-8p7scli8	420	20	I	-PRON-	PRP
cord-312001-8p7scli8	420	21	agonist	agonist	NN
cord-312001-8p7scli8	420	22	as	as	IN
cord-312001-8p7scli8	420	23	adjuvant	adjuvant	NN
cord-312001-8p7scli8	420	24	PIKA	PIKA	NNP
cord-312001-8p7scli8	420	25	as	as	IN
cord-312001-8p7scli8	420	26	an	an	DT
cord-312001-8p7scli8	420	27	adjuvant	adjuvant	NN
cord-312001-8p7scli8	420	28	enhances	enhance	VBZ
cord-312001-8p7scli8	420	29	specific	specific	JJ
cord-312001-8p7scli8	420	30	humoral	humoral	JJ
cord-312001-8p7scli8	420	31	and	and	CC
cord-312001-8p7scli8	420	32	cellular	cellular	JJ
cord-312001-8p7scli8	420	33	immune	immune	JJ
cord-312001-8p7scli8	420	34	responses	response	NNS
cord-312001-8p7scli8	420	35	following	follow	VBG
cord-312001-8p7scli8	420	36	the	the	DT
cord-312001-8p7scli8	420	37	vaccination	vaccination	NN
cord-312001-8p7scli8	420	38	of	of	IN
cord-312001-8p7scli8	420	39	mice	mouse	NNS
cord-312001-8p7scli8	420	40	with	with	IN
cord-312001-8p7scli8	420	41	HBsAg	HBsAg	NNP
cord-312001-8p7scli8	420	42	plus	plus	CC
cord-312001-8p7scli8	420	43	PIKA	PIKA	NNP
cord-312001-8p7scli8	420	44	A	A	NNP
cord-312001-8p7scli8	420	45	TLR3	TLR3	NNP
cord-312001-8p7scli8	420	46	ligand	ligand	NN
cord-312001-8p7scli8	420	47	that	that	WDT
cord-312001-8p7scli8	420	48	exhibits	exhibit	VBZ
cord-312001-8p7scli8	420	49	potent	potent	JJ
cord-312001-8p7scli8	420	50	inhibition	inhibition	NN
cord-312001-8p7scli8	420	51	of	of	IN
cord-312001-8p7scli8	420	52	influenza	influenza	NN
cord-312001-8p7scli8	420	53	virus	virus	NN
cord-312001-8p7scli8	420	54	replication	replication	NN
cord-312001-8p7scli8	420	55	and	and	CC
cord-312001-8p7scli8	420	56	has	have	VBZ
cord-312001-8p7scli8	420	57	strong	strong	JJ
cord-312001-8p7scli8	420	58	adjuvant	adjuvant	JJ
cord-312001-8p7scli8	420	59	activity	activity	NN
cord-312001-8p7scli8	420	60	has	have	VBZ
cord-312001-8p7scli8	420	61	the	the	DT
cord-312001-8p7scli8	420	62	potential	potential	NN
cord-312001-8p7scli8	420	63	for	for	IN
cord-312001-8p7scli8	420	64	dual	dual	JJ
cord-312001-8p7scli8	420	65	applications	application	NNS
cord-312001-8p7scli8	420	66	in	in	IN
cord-312001-8p7scli8	420	67	an	an	DT
cord-312001-8p7scli8	420	68	influenza	influenza	NN
cord-312001-8p7scli8	420	69	pandemic	pandemic	NN
cord-312001-8p7scli8	420	70	AS04	AS04	NNP
cord-312001-8p7scli8	420	71	,	,	,
cord-312001-8p7scli8	420	72	an	an	DT
cord-312001-8p7scli8	420	73	aluminum	aluminum	NN
cord-312001-8p7scli8	420	74	salt	salt	NN
cord-312001-8p7scli8	420	75	-	-	:
cord-312001-8p7scli8	420	76	and	and	CC
cord-312001-8p7scli8	420	77	TLR4	TLR4	NNP
cord-312001-8p7scli8	420	78	agonist	agonist	NN
cord-312001-8p7scli8	420	79	-	-	HYPH
cord-312001-8p7scli8	420	80	based	base	VBN
cord-312001-8p7scli8	420	81	adjuvant	adjuvant	NN
cord-312001-8p7scli8	420	82	system	system	NN
cord-312001-8p7scli8	420	83	,	,	,
cord-312001-8p7scli8	420	84	induces	induce	VBZ
cord-312001-8p7scli8	420	85	a	a	DT
cord-312001-8p7scli8	420	86	transient	transient	JJ
cord-312001-8p7scli8	420	87	localized	localize	VBN
cord-312001-8p7scli8	420	88	innate	innate	JJ
cord-312001-8p7scli8	420	89	immune	immune	JJ
cord-312001-8p7scli8	420	90	response	response	NN
cord-312001-8p7scli8	420	91	leading	lead	VBG
cord-312001-8p7scli8	420	92	to	to	IN
cord-312001-8p7scli8	420	93	enhanced	enhanced	JJ
cord-312001-8p7scli8	420	94	adaptive	adaptive	JJ
cord-312001-8p7scli8	420	95	immunity	immunity	NN
cord-312001-8p7scli8	421	1	The	the	DT
cord-312001-8p7scli8	421	2	TLR4	TLR4	NNP
cord-312001-8p7scli8	421	3	agonist	agonist	NN
cord-312001-8p7scli8	421	4	,	,	,
cord-312001-8p7scli8	421	5	monophosphoryl	monophosphoryl	NNP
cord-312001-8p7scli8	421	6	lipid	lipid	VBG
cord-312001-8p7scli8	421	7	A	A	NNP
cord-312001-8p7scli8	421	8	,	,	,
cord-312001-8p7scli8	421	9	attenuates	attenuate	VBZ
cord-312001-8p7scli8	421	10	the	the	DT
cord-312001-8p7scli8	421	11	cytokine	cytokine	NN
cord-312001-8p7scli8	421	12	storm	storm	NN
cord-312001-8p7scli8	421	13	associated	associate	VBN
cord-312001-8p7scli8	421	14	with	with	IN
cord-312001-8p7scli8	421	15	respiratory	respiratory	JJ
cord-312001-8p7scli8	421	16	syncytial	syncytial	JJ
cord-312001-8p7scli8	421	17	virus	virus	NN
cord-312001-8p7scli8	421	18	vaccine	vaccine	NN
cord-312001-8p7scli8	421	19	-	-	HYPH
cord-312001-8p7scli8	421	20	enhanced	enhance	VBN
cord-312001-8p7scli8	421	21	disease	disease	NN
cord-312001-8p7scli8	421	22	STING	sting	NN
cord-312001-8p7scli8	421	23	agonists	agonist	NNS
cord-312001-8p7scli8	421	24	enable	enable	VBP
cord-312001-8p7scli8	421	25	antiviral	antiviral	JJ
cord-312001-8p7scli8	421	26	cross	cross	NN
cord-312001-8p7scli8	421	27	-	-	NN
cord-312001-8p7scli8	421	28	talk	talk	NN
cord-312001-8p7scli8	421	29	between	between	IN
cord-312001-8p7scli8	421	30	human	human	JJ
cord-312001-8p7scli8	421	31	cells	cell	NNS
cord-312001-8p7scli8	421	32	and	and	CC
cord-312001-8p7scli8	421	33	confer	confer	VB
cord-312001-8p7scli8	421	34	protection	protection	NN
cord-312001-8p7scli8	421	35	against	against	IN
cord-312001-8p7scli8	421	36	genital	genital	JJ
cord-312001-8p7scli8	421	37	herpes	herpe	NNS
cord-312001-8p7scli8	421	38	in	in	IN
cord-312001-8p7scli8	421	39	mice	mouse	NNS
cord-312001-8p7scli8	422	1	The	the	DT
cord-312001-8p7scli8	422	2	TLR4	TLR4	NNP
cord-312001-8p7scli8	422	3	antagonist	antagonist	NN
cord-312001-8p7scli8	422	4	Eritoran	Eritoran	NNP
cord-312001-8p7scli8	422	5	protects	protect	VBZ
cord-312001-8p7scli8	422	6	mice	mouse	NNS
cord-312001-8p7scli8	422	7	from	from	IN
cord-312001-8p7scli8	422	8	lethal	lethal	JJ
cord-312001-8p7scli8	422	9	influenza	influenza	NN
cord-312001-8p7scli8	422	10	infection	infection	NN
cord-312001-8p7scli8	422	11	Targeting	target	VBG
cord-312001-8p7scli8	422	12	innate	innate	JJ
cord-312001-8p7scli8	422	13	immunity	immunity	NN
cord-312001-8p7scli8	422	14	for	for	IN
cord-312001-8p7scli8	422	15	antiviral	antiviral	JJ
cord-312001-8p7scli8	422	16	therapy	therapy	NN
cord-312001-8p7scli8	422	17	through	through	IN
cord-312001-8p7scli8	422	18	small	small	JJ
cord-312001-8p7scli8	422	19	molecule	molecule	NN
cord-312001-8p7scli8	422	20	agonists	agonist	NNS
cord-312001-8p7scli8	422	21	of	of	IN
cord-312001-8p7scli8	422	22	the	the	DT
cord-312001-8p7scli8	422	23	RLR	RLR	NNP
cord-312001-8p7scli8	422	24	pathway	pathway	NN
cord-312001-8p7scli8	422	25	Direct	direct	JJ
cord-312001-8p7scli8	422	26	antiviral	antiviral	JJ
cord-312001-8p7scli8	422	27	properties	property	NNS
cord-312001-8p7scli8	422	28	of	of	IN
cord-312001-8p7scli8	422	29	TLR	TLR	NNP
cord-312001-8p7scli8	422	30	ligands	ligand	NNS
cord-312001-8p7scli8	422	31	against	against	IN
cord-312001-8p7scli8	422	32	HBV	HBV	NNP
cord-312001-8p7scli8	422	33	replication	replication	NN
cord-312001-8p7scli8	422	34	in	in	IN
cord-312001-8p7scli8	422	35	immune	immune	JJ
cord-312001-8p7scli8	422	36	-	-	HYPH
cord-312001-8p7scli8	422	37	competent	competent	JJ
cord-312001-8p7scli8	422	38	hepatocytes	hepatocyte	NNS
cord-312001-8p7scli8	422	39	Safety	Safety	NNP
cord-312001-8p7scli8	422	40	,	,	,
cord-312001-8p7scli8	422	41	efficacy	efficacy	NN
cord-312001-8p7scli8	422	42	and	and	CC
cord-312001-8p7scli8	422	43	pharmacodynamics	pharmacodynamic	NNS
cord-312001-8p7scli8	422	44	of	of	IN
cord-312001-8p7scli8	422	45	vesatolimod	vesatolimod	NNP
cord-312001-8p7scli8	422	46	(	(	-LRB-
cord-312001-8p7scli8	422	47	GS-9620	GS-9620	NNP
cord-312001-8p7scli8	422	48	)	)	-RRB-
cord-312001-8p7scli8	422	49	in	in	IN
cord-312001-8p7scli8	422	50	virally	virally	RB
cord-312001-8p7scli8	422	51	suppressed	suppress	VBN
cord-312001-8p7scli8	422	52	patients	patient	NNS
cord-312001-8p7scli8	422	53	with	with	IN
cord-312001-8p7scli8	422	54	chronic	chronic	JJ
cord-312001-8p7scli8	422	55	hepatitis	hepatitis	NN
cord-312001-8p7scli8	422	56	B	B	NNP
cord-312001-8p7scli8	422	57	Antibody	Antibody	NNP
cord-312001-8p7scli8	422	58	and	and	CC
cord-312001-8p7scli8	422	59	TLR7	TLR7	NNP
cord-312001-8p7scli8	422	60	agonist	agonist	NN
cord-312001-8p7scli8	422	61	delay	delay	NN
cord-312001-8p7scli8	422	62	viral	viral	JJ
cord-312001-8p7scli8	422	63	rebound	rebound	NN
cord-312001-8p7scli8	422	64	in	in	IN
cord-312001-8p7scli8	422	65	SHIV	SHIV	NNP
cord-312001-8p7scli8	422	66	-	-	HYPH
cord-312001-8p7scli8	422	67	infected	infect	VBN
cord-312001-8p7scli8	422	68	monkeys	monkey	NNS
cord-312001-8p7scli8	422	69	Therapeutic	therapeutic	JJ
cord-312001-8p7scli8	422	70	effects	effect	NNS
cord-312001-8p7scli8	422	71	of	of	IN
cord-312001-8p7scli8	422	72	the	the	DT
cord-312001-8p7scli8	422	73	artemisinin	artemisinin	NN
cord-312001-8p7scli8	422	74	analog	analog	NN
cord-312001-8p7scli8	423	1	SM934	sm934	NN
cord-312001-8p7scli8	423	2	on	on	IN
cord-312001-8p7scli8	423	3	lupus	lupus	NN
cord-312001-8p7scli8	423	4	-	-	HYPH
cord-312001-8p7scli8	423	5	prone	prone	JJ
cord-312001-8p7scli8	423	6	MRL	MRL	NNP
cord-312001-8p7scli8	423	7	/	/	SYM
cord-312001-8p7scli8	423	8	lpr	lpr	NN
cord-312001-8p7scli8	423	9	mice	mouse	NNS
cord-312001-8p7scli8	424	1	via	via	IN
cord-312001-8p7scli8	424	2	inhibition	inhibition	NN
cord-312001-8p7scli8	424	3	of	of	IN
cord-312001-8p7scli8	424	4	TLR	TLR	NNP
cord-312001-8p7scli8	424	5	-	-	HYPH
cord-312001-8p7scli8	424	6	triggered	trigger	VBN
cord-312001-8p7scli8	424	7	B	b	NN
cord-312001-8p7scli8	424	8	-	-	HYPH
cord-312001-8p7scli8	424	9	cell	cell	NN
cord-312001-8p7scli8	424	10	activation	activation	NN
cord-312001-8p7scli8	424	11	and	and	CC
cord-312001-8p7scli8	424	12	plasma	plasma	NN
cord-312001-8p7scli8	424	13	cell	cell	NN
cord-312001-8p7scli8	424	14	formation	formation	NN
cord-312001-8p7scli8	424	15	TAK-242	TAK-242	NNP
cord-312001-8p7scli8	424	16	(	(	-LRB-
cord-312001-8p7scli8	424	17	resatorvid	resatorvid	NNP
cord-312001-8p7scli8	424	18	)	)	-RRB-
cord-312001-8p7scli8	424	19	,	,	,
cord-312001-8p7scli8	424	20	a	a	DT
cord-312001-8p7scli8	424	21	small	small	JJ
cord-312001-8p7scli8	424	22	-	-	HYPH
cord-312001-8p7scli8	424	23	molecule	molecule	NN
cord-312001-8p7scli8	424	24	inhibitor	inhibitor	NN
cord-312001-8p7scli8	424	25	of	of	IN
cord-312001-8p7scli8	424	26	Toll	Toll	NNP
cord-312001-8p7scli8	424	27	-	-	HYPH
cord-312001-8p7scli8	424	28	like	like	JJ
cord-312001-8p7scli8	424	29	receptor	receptor	NN
cord-312001-8p7scli8	424	30	(	(	-LRB-
cord-312001-8p7scli8	424	31	TLR	TLR	NNP
cord-312001-8p7scli8	424	32	)	)	-RRB-
cord-312001-8p7scli8	425	1	4	4	LS
cord-312001-8p7scli8	425	2	signaling	signal	VBG
cord-312001-8p7scli8	425	3	,	,	,
cord-312001-8p7scli8	425	4	binds	bind	VBZ
cord-312001-8p7scli8	425	5	selectively	selectively	RB
cord-312001-8p7scli8	425	6	to	to	IN
cord-312001-8p7scli8	425	7	TLR4	TLR4	NNP
cord-312001-8p7scli8	425	8	and	and	CC
cord-312001-8p7scli8	425	9	interferes	interfere	VBZ
cord-312001-8p7scli8	425	10	with	with	IN
cord-312001-8p7scli8	425	11	interactions	interaction	NNS
cord-312001-8p7scli8	425	12	between	between	IN
cord-312001-8p7scli8	425	13	TLR4	TLR4	NNP
cord-312001-8p7scli8	425	14	and	and	CC
cord-312001-8p7scli8	425	15	its	-PRON-	PRP$
cord-312001-8p7scli8	425	16	adaptor	adaptor	NN
cord-312001-8p7scli8	425	17	molecules	molecule	NNS
cord-312001-8p7scli8	425	18	essential	essential	JJ
cord-312001-8p7scli8	425	19	for	for	IN
cord-312001-8p7scli8	425	20	the	the	DT
cord-312001-8p7scli8	425	21	antitumor	antitumor	JJ
cord-312001-8p7scli8	425	22	effect	effect	NN
cord-312001-8p7scli8	425	23	of	of	IN
cord-312001-8p7scli8	425	24	immune	immune	JJ
cord-312001-8p7scli8	425	25	checkpoint	checkpoint	NN
cord-312001-8p7scli8	425	26	blockade	blockade	NN
cord-312001-8p7scli8	425	27	SA-4	SA-4	NNP
cord-312001-8p7scli8	425	28	-	-	HYPH
cord-312001-8p7scli8	425	29	1BBL	1BBL	NNP
cord-312001-8p7scli8	425	30	and	and	CC
cord-312001-8p7scli8	425	31	monophosphoryl	monophosphoryl	NNP
cord-312001-8p7scli8	426	1	lipid	lipid	NNP
cord-312001-8p7scli8	426	2	A	a	DT
cord-312001-8p7scli8	426	3	constitute	constitute	VBP
cord-312001-8p7scli8	426	4	an	an	DT
cord-312001-8p7scli8	426	5	efficacious	efficacious	JJ
cord-312001-8p7scli8	426	6	combination	combination	NN
cord-312001-8p7scli8	426	7	adjuvant	adjuvant	NN
cord-312001-8p7scli8	426	8	for	for	IN
cord-312001-8p7scli8	426	9	cancer	cancer	NN
cord-312001-8p7scli8	426	10	vaccines	vaccine	NNS
cord-312001-8p7scli8	427	1	Magnitude	magnitude	NN
cord-312001-8p7scli8	427	2	of	of	IN
cord-312001-8p7scli8	427	3	Therapeutic	therapeutic	JJ
cord-312001-8p7scli8	427	4	STING	sting	NN
cord-312001-8p7scli8	427	5	Activation	activation	NN
cord-312001-8p7scli8	427	6	Determines	determine	VBZ
cord-312001-8p7scli8	427	7	CD8(+	CD8(+	NNP
cord-312001-8p7scli8	427	8	)	)	-RRB-
cord-312001-8p7scli8	428	1	T	T	NNP
cord-312001-8p7scli8	428	2	Cell	Cell	NNP
cord-312001-8p7scli8	428	3	-	-	HYPH
cord-312001-8p7scli8	428	4	Mediated	mediate	VBN
cord-312001-8p7scli8	428	5	Anti	anti	JJ
cord-312001-8p7scli8	428	6	-	-	JJ
cord-312001-8p7scli8	428	7	tumor	tumor	JJ
cord-312001-8p7scli8	428	8	Immunity	Immunity	NNP
cord-312001-8p7scli8	428	9	Immunogene	Immunogene	NNP
cord-312001-8p7scli8	428	10	therapy	therapy	NN
cord-312001-8p7scli8	428	11	using	use	VBG
cord-312001-8p7scli8	428	12	immunomodulating	immunomodulate	VBG
cord-312001-8p7scli8	428	13	HVJ	hvj	NN
cord-312001-8p7scli8	428	14	-	-	HYPH
cord-312001-8p7scli8	428	15	E	e	NN
cord-312001-8p7scli8	428	16	vector	vector	NN
cord-312001-8p7scli8	428	17	augments	augment	VBZ
cord-312001-8p7scli8	428	18	anti	anti	JJ
cord-312001-8p7scli8	428	19	-	-	JJ
cord-312001-8p7scli8	428	20	tumor	tumor	JJ
cord-312001-8p7scli8	428	21	effects	effect	NNS
cord-312001-8p7scli8	428	22	in	in	IN
cord-312001-8p7scli8	428	23	murine	murine	JJ
cord-312001-8p7scli8	428	24	malignant	malignant	JJ
cord-312001-8p7scli8	428	25	glioma	glioma	NN
cord-312001-8p7scli8	428	26	Promising	promise	VBG
cord-312001-8p7scli8	428	27	targets	target	NNS
cord-312001-8p7scli8	428	28	for	for	IN
cord-312001-8p7scli8	428	29	cancer	cancer	NN
cord-312001-8p7scli8	428	30	immunotherapy	immunotherapy	NN
cord-312001-8p7scli8	428	31	:	:	:
cord-312001-8p7scli8	428	32	TLRs	TLRs	NNP
cord-312001-8p7scli8	428	33	,	,	,
cord-312001-8p7scli8	428	34	RLRs	rlr	NNS
cord-312001-8p7scli8	428	35	,	,	,
cord-312001-8p7scli8	428	36	and	and	CC
cord-312001-8p7scli8	428	37	STING	sting	NN
cord-312001-8p7scli8	428	38	-	-	HYPH
cord-312001-8p7scli8	428	39	mediated	mediate	VBN
cord-312001-8p7scli8	428	40	innate	innate	JJ
cord-312001-8p7scli8	428	41	immune	immune	JJ
cord-312001-8p7scli8	428	42	pathways	pathway	NNS
cord-312001-8p7scli8	428	43	Immunogenic	immunogenic	JJ
cord-312001-8p7scli8	428	44	cell	cell	NN
cord-312001-8p7scli8	428	45	death	death	NN
cord-312001-8p7scli8	428	46	of	of	IN
cord-312001-8p7scli8	428	47	human	human	JJ
cord-312001-8p7scli8	428	48	ovarian	ovarian	JJ
cord-312001-8p7scli8	428	49	cancer	cancer	NN
cord-312001-8p7scli8	428	50	cells	cell	NNS
cord-312001-8p7scli8	428	51	induced	induce	VBN
cord-312001-8p7scli8	428	52	by	by	IN
cord-312001-8p7scli8	428	53	cytosolic	cytosolic	JJ
cord-312001-8p7scli8	428	54	poly(I	poly(I	NNP
cord-312001-8p7scli8	428	55	:	:	:
cord-312001-8p7scli8	428	56	C	C	NNP
cord-312001-8p7scli8	428	57	)	)	-RRB-
cord-312001-8p7scli8	428	58	leads	lead	VBZ
cord-312001-8p7scli8	428	59	to	to	IN
cord-312001-8p7scli8	428	60	myeloid	myeloid	JJ
cord-312001-8p7scli8	428	61	cell	cell	NN
cord-312001-8p7scli8	428	62	maturation	maturation	NN
cord-312001-8p7scli8	428	63	and	and	CC
cord-312001-8p7scli8	428	64	activates	activate	VBZ
cord-312001-8p7scli8	428	65	NK	NK	NNP
cord-312001-8p7scli8	428	66	cells	cell	NNS
cord-312001-8p7scli8	428	67	STING	sting	NN
cord-312001-8p7scli8	428	68	-	-	HYPH
cord-312001-8p7scli8	428	69	mediated	mediate	VBN
cord-312001-8p7scli8	428	70	DNA	dna	NN
cord-312001-8p7scli8	428	71	sensing	sensing	NN
cord-312001-8p7scli8	428	72	promotes	promote	VBZ
cord-312001-8p7scli8	428	73	antitumor	antitumor	JJ
cord-312001-8p7scli8	428	74	and	and	CC
cord-312001-8p7scli8	428	75	autoimmune	autoimmune	JJ
cord-312001-8p7scli8	428	76	responses	response	NNS
cord-312001-8p7scli8	428	77	to	to	IN
cord-312001-8p7scli8	428	78	dying	die	VBG
cord-312001-8p7scli8	428	79	cells	cell	NNS
cord-312001-8p7scli8	428	80	STING	sting	VB
cord-312001-8p7scli8	428	81	agonist	agonist	NN
cord-312001-8p7scli8	429	1	formulated	formulate	VBN
cord-312001-8p7scli8	429	2	cancer	cancer	NN
cord-312001-8p7scli8	429	3	vaccines	vaccine	NNS
cord-312001-8p7scli8	429	4	can	can	MD
cord-312001-8p7scli8	429	5	cure	cure	VB
cord-312001-8p7scli8	429	6	established	establish	VBN
cord-312001-8p7scli8	429	7	tumors	tumor	NNS
cord-312001-8p7scli8	429	8	resistant	resistant	JJ
cord-312001-8p7scli8	429	9	to	to	IN
cord-312001-8p7scli8	429	10	PD-1	PD-1	NNP
cord-312001-8p7scli8	429	11	blockade	blockade	NN
cord-312001-8p7scli8	430	1	This	this	DT
cord-312001-8p7scli8	430	2	article	article	NN
cord-312001-8p7scli8	430	3	is	be	VBZ
cord-312001-8p7scli8	430	4	an	an	DT
cord-312001-8p7scli8	430	5	open	open	JJ
cord-312001-8p7scli8	430	6	access	access	NN
cord-312001-8p7scli8	430	7	article	article	NN
cord-312001-8p7scli8	430	8	distributed	distribute	VBN
cord-312001-8p7scli8	430	9	under	under	IN
cord-312001-8p7scli8	430	10	the	the	DT
cord-312001-8p7scli8	430	11	terms	term	NNS
cord-312001-8p7scli8	430	12	and	and	CC
cord-312001-8p7scli8	430	13	conditions	condition	NNS
cord-312001-8p7scli8	430	14	of	of	IN
cord-312001-8p7scli8	430	15	the	the	DT
cord-312001-8p7scli8	430	16	Creative	Creative	NNP
cord-312001-8p7scli8	430	17	Commons	Commons	NNP
cord-312001-8p7scli8	430	18	Attribution	Attribution	NNP
cord-312001-8p7scli8	430	19	(	(	-LRB-
cord-312001-8p7scli8	430	20	CC	CC	NNP
cord-312001-8p7scli8	430	21	BY	by	IN
cord-312001-8p7scli8	430	22	)	)	-RRB-
cord-312001-8p7scli8	430	23	license	license	NN
cord-312001-8p7scli8	430	24	Funding	funding	NN
cord-312001-8p7scli8	430	25	:	:	:
cord-312001-8p7scli8	431	1	This	this	DT
cord-312001-8p7scli8	431	2	work	work	NN
cord-312001-8p7scli8	431	3	has	have	VBZ
cord-312001-8p7scli8	431	4	been	be	VBN
cord-312001-8p7scli8	431	5	supported	support	VBN
cord-312001-8p7scli8	431	6	by	by	IN
cord-312001-8p7scli8	431	7	the	the	DT
cord-312001-8p7scli8	431	8	H2020	H2020	NNP
cord-312001-8p7scli8	431	9	Marie	Marie	NNP
cord-312001-8p7scli8	431	10	-	-	HYPH
cord-312001-8p7scli8	431	11	Curie	Curie	NNP
cord-312001-8p7scli8	431	12	Actions	Actions	NNPS
cord-312001-8p7scli8	431	13	MSCA	MSCA	NNP
cord-312001-8p7scli8	431	14	-	-	HYPH
cord-312001-8p7scli8	431	15	IF-792661-HipShot	IF-792661-HipShot	NNP
cord-312001-8p7scli8	431	16	(	(	-LRB-
cord-312001-8p7scli8	431	17	KM	KM	NNP
cord-312001-8p7scli8	431	18	)	)	-RRB-
cord-312001-8p7scli8	431	19	.	.	.
cord-312001-8p7scli8	432	1	This	this	DT
cord-312001-8p7scli8	432	2	work	work	NN
cord-312001-8p7scli8	432	3	was	be	VBD
cord-312001-8p7scli8	432	4	also	also	RB
cord-312001-8p7scli8	432	5	supported	support	VBN
cord-312001-8p7scli8	432	6	in	in	IN
cord-312001-8p7scli8	432	7	part	part	NN
cord-312001-8p7scli8	432	8	by	by	IN
cord-312001-8p7scli8	432	9	the	the	DT
cord-312001-8p7scli8	432	10	National	National	NNP
cord-312001-8p7scli8	432	11	Institutes	Institutes	NNPS
cord-312001-8p7scli8	432	12	of	of	IN
cord-312001-8p7scli8	432	13	Health	Health	NNP
cord-312001-8p7scli8	432	14	grants	grant	NNS
cord-312001-8p7scli8	432	15	U19-AI123862	U19-AI123862	NNP
cord-312001-8p7scli8	433	1	(	(	-LRB-
cord-312001-8p7scli8	433	2	TFB	TFB	NNP
cord-312001-8p7scli8	433	3	)	)	-RRB-
cord-312001-8p7scli8	433	4	by	by	IN
cord-312001-8p7scli8	433	5	ARC	ARC	NNP
cord-312001-8p7scli8	433	6	,	,	,
cord-312001-8p7scli8	433	7	Paris	Paris	NNP
cord-312001-8p7scli8	433	8	and	and	CC
cord-312001-8p7scli8	433	9	Institut	Institut	NNP
cord-312001-8p7scli8	433	10	Hospitalo	Hospitalo	NNP
cord-312001-8p7scli8	433	11	-	-	HYPH
cord-312001-8p7scli8	433	12	Universitaire	Universitaire	NNP
cord-312001-8p7scli8	433	13	,	,	,
cord-312001-8p7scli8	433	14	Strasbourg	Strasbourg	NNP
cord-312001-8p7scli8	433	15	(	(	-LRB-
cord-312001-8p7scli8	433	16	TheraHCC	therahcc	XX
cord-312001-8p7scli8	434	1	and	and	CC
cord-312001-8p7scli8	434	2	TheraHCC2.0	TheraHCC2.0	``
cord-312001-8p7scli8	434	3	IHUARC	IHUARC	NNP
cord-312001-8p7scli8	435	1	IHU201301187	IHU201301187	NNP
cord-312001-8p7scli8	435	2	and	and	CC
cord-312001-8p7scli8	435	3	IHUARC2019	IHUARC2019	NNP
cord-312001-8p7scli8	436	1	to	to	IN
cord-312001-8p7scli8	436	2	T.	T.	NNP
cord-312001-8p7scli8	436	3	Acknowledgments	acknowledgment	NNS
cord-312001-8p7scli8	436	4	:	:	:
cord-312001-8p7scli8	437	1	The	the	DT
cord-312001-8p7scli8	437	2	authors	author	NNS
cord-312001-8p7scli8	437	3	would	would	MD
cord-312001-8p7scli8	437	4	like	like	VB
cord-312001-8p7scli8	437	5	to	to	TO
cord-312001-8p7scli8	437	6	thank	thank	VB
cord-312001-8p7scli8	437	7	Jean	Jean	NNP
cord-312001-8p7scli8	437	8	-	-	HYPH
cord-312001-8p7scli8	437	9	Luc	Luc	NNP
cord-312001-8p7scli8	437	10	Imler	Imler	NNP
cord-312001-8p7scli8	437	11	and	and	CC
cord-312001-8p7scli8	437	12	Joao	Joao	NNP
cord-312001-8p7scli8	437	13	T.	T.	NNP
cord-312001-8p7scli8	437	14	Marques	Marques	NNP
cord-312001-8p7scli8	437	15	for	for	IN
cord-312001-8p7scli8	437	16	their	-PRON-	PRP$
cord-312001-8p7scli8	437	17	critical	critical	JJ
cord-312001-8p7scli8	437	18	reading	reading	NN
cord-312001-8p7scli8	437	19	of	of	IN
cord-312001-8p7scli8	437	20	the	the	DT
cord-312001-8p7scli8	437	21	manuscript	manuscript	NN
cord-312001-8p7scli8	437	22	.	.	.
cord-312001-8p7scli8	438	1	The	the	DT
cord-312001-8p7scli8	438	2	authors	author	NNS
cord-312001-8p7scli8	438	3	apologize	apologize	VBP
cord-312001-8p7scli8	438	4	to	to	IN
cord-312001-8p7scli8	438	5	colleagues	colleague	NNS
cord-312001-8p7scli8	438	6	whose	whose	WP$
cord-312001-8p7scli8	438	7	work	work	NN
cord-312001-8p7scli8	438	8	could	could	MD
cord-312001-8p7scli8	438	9	not	not	RB
cord-312001-8p7scli8	438	10	be	be	VB
cord-312001-8p7scli8	438	11	cited	cite	VBN
cord-312001-8p7scli8	438	12	due	due	IN
cord-312001-8p7scli8	438	13	to	to	IN
cord-312001-8p7scli8	438	14	space	space	NN
cord-312001-8p7scli8	438	15	limitations	limitation	NNS
cord-312001-8p7scli8	438	16	.	.	.
cord-312001-8p7scli8	439	1	The	the	DT
cord-312001-8p7scli8	439	2	authors	author	NNS
cord-312001-8p7scli8	439	3	declare	declare	VBP
cord-312001-8p7scli8	439	4	no	no	DT
cord-312001-8p7scli8	439	5	conflict	conflict	NN
cord-312001-8p7scli8	439	6	of	of	IN
cord-312001-8p7scli8	439	7	interest	interest	NN
cord-312001-8p7scli8	439	8	.	.	.