id	sid	tid	token	lemma	pos
cord-318495-1w74wf02	1	1	key	key	JJ
cord-318495-1w74wf02	1	2	:	:	:
cord-318495-1w74wf02	1	3	cord-318495	cord-318495	NNP
cord-318495-1w74wf02	1	4	-	-	HYPH
cord-318495-1w74wf02	1	5	1w74wf02	1w74wf02	CD
cord-318495-1w74wf02	1	6	authors	author	NNS
cord-318495-1w74wf02	1	7	:	:	:
cord-318495-1w74wf02	1	8	Vignuzzi	Vignuzzi	NNP
cord-318495-1w74wf02	1	9	,	,	,
cord-318495-1w74wf02	1	10	Marco	Marco	NNP
cord-318495-1w74wf02	1	11	;	;	:
cord-318495-1w74wf02	1	12	López	López	NNP
cord-318495-1w74wf02	1	13	,	,	,
cord-318495-1w74wf02	1	14	Carolina	Carolina	NNP
cord-318495-1w74wf02	1	15	B.	B.	NNP
cord-318495-1w74wf02	1	16	title	title	NN
cord-318495-1w74wf02	1	17	:	:	:
cord-318495-1w74wf02	2	1	Defective	defective	JJ
cord-318495-1w74wf02	2	2	viral	viral	JJ
cord-318495-1w74wf02	2	3	genomes	genome	NNS
cord-318495-1w74wf02	2	4	are	be	VBP
cord-318495-1w74wf02	2	5	key	key	JJ
cord-318495-1w74wf02	2	6	drivers	driver	NNS
cord-318495-1w74wf02	2	7	of	of	IN
cord-318495-1w74wf02	2	8	the	the	DT
cord-318495-1w74wf02	2	9	virus	virus	NN
cord-318495-1w74wf02	2	10	–	–	:
cord-318495-1w74wf02	2	11	host	host	NN
cord-318495-1w74wf02	2	12	interaction	interaction	NN
cord-318495-1w74wf02	2	13	date	date	NN
cord-318495-1w74wf02	2	14	:	:	:
cord-318495-1w74wf02	2	15	2019	2019	CD
cord-318495-1w74wf02	2	16	-	-	HYPH
cord-318495-1w74wf02	2	17	06	06	CD
cord-318495-1w74wf02	2	18	-	-	HYPH
cord-318495-1w74wf02	2	19	03	03	CD
cord-318495-1w74wf02	2	20	journal	journal	NN
cord-318495-1w74wf02	2	21	:	:	:
cord-318495-1w74wf02	3	1	Nat	Nat	NNP
cord-318495-1w74wf02	3	2	Microbiol	Microbiol	NNP
cord-318495-1w74wf02	3	3	DOI	DOI	NNP
cord-318495-1w74wf02	3	4	:	:	:
cord-318495-1w74wf02	3	5	10.1038	10.1038	CD
cord-318495-1w74wf02	3	6	/	/	SYM
cord-318495-1w74wf02	3	7	s41564	s41564	NN
cord-318495-1w74wf02	3	8	-	-	HYPH
cord-318495-1w74wf02	3	9	019	019	CD
cord-318495-1w74wf02	3	10	-	-	HYPH
cord-318495-1w74wf02	3	11	0465-y	0465-y	NNP
cord-318495-1w74wf02	4	1	sha	sha	NNP
cord-318495-1w74wf02	4	2	:	:	:
cord-318495-1w74wf02	5	1	f6f50fdeb1926817fd6a4249af10a46af8539caf	f6f50fdeb1926817fd6a4249af10a46af8539caf	NNP
cord-318495-1w74wf02	5	2	doc_id	doc_id	CD
cord-318495-1w74wf02	5	3	:	:	:
cord-318495-1w74wf02	5	4	318495	318495	CD
cord-318495-1w74wf02	5	5	cord_uid	cord_uid	FW
cord-318495-1w74wf02	5	6	:	:	:
cord-318495-1w74wf02	6	1	1w74wf02	1w74wf02	CD
cord-318495-1w74wf02	6	2	Viruses	virus	NNS
cord-318495-1w74wf02	6	3	survive	survive	VBP
cord-318495-1w74wf02	6	4	often	often	RB
cord-318495-1w74wf02	6	5	harsh	harsh	JJ
cord-318495-1w74wf02	6	6	host	host	NN
cord-318495-1w74wf02	6	7	environments	environment	NNS
cord-318495-1w74wf02	6	8	,	,	,
cord-318495-1w74wf02	6	9	yet	yet	CC
cord-318495-1w74wf02	6	10	we	-PRON-	PRP
cord-318495-1w74wf02	6	11	know	know	VBP
cord-318495-1w74wf02	6	12	little	little	JJ
cord-318495-1w74wf02	6	13	about	about	IN
cord-318495-1w74wf02	6	14	the	the	DT
cord-318495-1w74wf02	6	15	strategies	strategy	NNS
cord-318495-1w74wf02	6	16	they	-PRON-	PRP
cord-318495-1w74wf02	6	17	utilize	utilize	VBP
cord-318495-1w74wf02	6	18	to	to	TO
cord-318495-1w74wf02	6	19	adapt	adapt	VB
cord-318495-1w74wf02	6	20	and	and	CC
cord-318495-1w74wf02	6	21	subsist	subsist	VBP
cord-318495-1w74wf02	6	22	given	give	VBN
cord-318495-1w74wf02	6	23	their	-PRON-	PRP$
cord-318495-1w74wf02	6	24	limited	limited	JJ
cord-318495-1w74wf02	6	25	genomic	genomic	JJ
cord-318495-1w74wf02	6	26	resources	resource	NNS
cord-318495-1w74wf02	6	27	.	.	.
cord-318495-1w74wf02	7	1	We	-PRON-	PRP
cord-318495-1w74wf02	7	2	are	be	VBP
cord-318495-1w74wf02	7	3	beginning	begin	VBG
cord-318495-1w74wf02	7	4	to	to	TO
cord-318495-1w74wf02	7	5	appreciate	appreciate	VB
cord-318495-1w74wf02	7	6	the	the	DT
cord-318495-1w74wf02	7	7	surprising	surprising	JJ
cord-318495-1w74wf02	7	8	versatility	versatility	NN
cord-318495-1w74wf02	7	9	of	of	IN
cord-318495-1w74wf02	7	10	viral	viral	JJ
cord-318495-1w74wf02	7	11	genomes	genome	NNS
cord-318495-1w74wf02	7	12	and	and	CC
cord-318495-1w74wf02	7	13	how	how	WRB
cord-318495-1w74wf02	7	14	replication	replication	NN
cord-318495-1w74wf02	7	15	-	-	HYPH
cord-318495-1w74wf02	7	16	competent	competent	JJ
cord-318495-1w74wf02	7	17	and	and	CC
cord-318495-1w74wf02	7	18	-defective	-defective	JJ
cord-318495-1w74wf02	7	19	virus	virus	NN
cord-318495-1w74wf02	7	20	variants	variant	NNS
cord-318495-1w74wf02	7	21	can	can	MD
cord-318495-1w74wf02	7	22	provide	provide	VB
cord-318495-1w74wf02	7	23	means	mean	NNS
cord-318495-1w74wf02	7	24	for	for	IN
cord-318495-1w74wf02	7	25	adaptation	adaptation	NN
cord-318495-1w74wf02	7	26	,	,	,
cord-318495-1w74wf02	7	27	immune	immune	JJ
cord-318495-1w74wf02	7	28	escape	escape	NN
cord-318495-1w74wf02	7	29	and	and	CC
cord-318495-1w74wf02	7	30	virus	virus	NN
cord-318495-1w74wf02	7	31	perpetuation	perpetuation	NN
cord-318495-1w74wf02	7	32	.	.	.
cord-318495-1w74wf02	8	1	This	this	DT
cord-318495-1w74wf02	8	2	Review	Review	NNP
cord-318495-1w74wf02	8	3	summarizes	summarize	VBZ
cord-318495-1w74wf02	8	4	current	current	JJ
cord-318495-1w74wf02	8	5	knowledge	knowledge	NN
cord-318495-1w74wf02	8	6	of	of	IN
cord-318495-1w74wf02	8	7	the	the	DT
cord-318495-1w74wf02	8	8	types	type	NNS
cord-318495-1w74wf02	8	9	of	of	IN
cord-318495-1w74wf02	8	10	defective	defective	JJ
cord-318495-1w74wf02	8	11	viral	viral	JJ
cord-318495-1w74wf02	8	12	genomes	genome	NNS
cord-318495-1w74wf02	8	13	generated	generate	VBN
cord-318495-1w74wf02	8	14	during	during	IN
cord-318495-1w74wf02	8	15	the	the	DT
cord-318495-1w74wf02	8	16	replication	replication	NN
cord-318495-1w74wf02	8	17	of	of	IN
cord-318495-1w74wf02	8	18	RNA	RNA	NNP
cord-318495-1w74wf02	8	19	viruses	virus	NNS
cord-318495-1w74wf02	8	20	and	and	CC
cord-318495-1w74wf02	8	21	the	the	DT
cord-318495-1w74wf02	8	22	functions	function	NNS
cord-318495-1w74wf02	8	23	that	that	WDT
cord-318495-1w74wf02	8	24	they	-PRON-	PRP
cord-318495-1w74wf02	8	25	carry	carry	VBP
cord-318495-1w74wf02	8	26	out	out	RP
cord-318495-1w74wf02	8	27	.	.	.
cord-318495-1w74wf02	9	1	We	-PRON-	PRP
cord-318495-1w74wf02	9	2	highlight	highlight	VBP
cord-318495-1w74wf02	9	3	the	the	DT
cord-318495-1w74wf02	9	4	universality	universality	NN
cord-318495-1w74wf02	9	5	and	and	CC
cord-318495-1w74wf02	9	6	diversity	diversity	NN
cord-318495-1w74wf02	9	7	of	of	IN
cord-318495-1w74wf02	9	8	defective	defective	JJ
cord-318495-1w74wf02	9	9	viral	viral	JJ
cord-318495-1w74wf02	9	10	genomes	genome	NNS
cord-318495-1w74wf02	9	11	during	during	IN
cord-318495-1w74wf02	9	12	infections	infection	NNS
cord-318495-1w74wf02	9	13	and	and	CC
cord-318495-1w74wf02	9	14	discuss	discuss	VB
cord-318495-1w74wf02	9	15	their	-PRON-	PRP$
cord-318495-1w74wf02	9	16	predicted	predict	VBN
cord-318495-1w74wf02	9	17	role	role	NN
cord-318495-1w74wf02	9	18	in	in	IN
cord-318495-1w74wf02	9	19	maintaining	maintain	VBG
cord-318495-1w74wf02	9	20	a	a	DT
cord-318495-1w74wf02	9	21	fit	fit	JJ
cord-318495-1w74wf02	9	22	virus	virus	NN
cord-318495-1w74wf02	9	23	population	population	NN
cord-318495-1w74wf02	9	24	,	,	,
cord-318495-1w74wf02	9	25	their	-PRON-	PRP$
cord-318495-1w74wf02	9	26	impact	impact	NN
cord-318495-1w74wf02	9	27	on	on	IN
cord-318495-1w74wf02	9	28	human	human	JJ
cord-318495-1w74wf02	9	29	and	and	CC
cord-318495-1w74wf02	9	30	animal	animal	NN
cord-318495-1w74wf02	9	31	health	health	NN
cord-318495-1w74wf02	9	32	,	,	,
cord-318495-1w74wf02	9	33	and	and	CC
cord-318495-1w74wf02	9	34	their	-PRON-	PRP$
cord-318495-1w74wf02	9	35	potential	potential	NN
cord-318495-1w74wf02	9	36	to	to	TO
cord-318495-1w74wf02	9	37	be	be	VB
cord-318495-1w74wf02	9	38	harnessed	harness	VBN
cord-318495-1w74wf02	9	39	as	as	IN
cord-318495-1w74wf02	9	40	antiviral	antiviral	JJ
cord-318495-1w74wf02	9	41	tools	tool	NNS
cord-318495-1w74wf02	9	42	.	.	.
cord-318495-1w74wf02	10	1	V	V	NNP
cord-318495-1w74wf02	10	2	iruses	iruse	NNS
cord-318495-1w74wf02	10	3	are	be	VBP
cord-318495-1w74wf02	10	4	remarkably	remarkably	RB
cord-318495-1w74wf02	10	5	resilient	resilient	JJ
cord-318495-1w74wf02	10	6	microorganisms	microorganism	NNS
cord-318495-1w74wf02	10	7	able	able	JJ
cord-318495-1w74wf02	10	8	to	to	TO
cord-318495-1w74wf02	10	9	adapt	adapt	VB
cord-318495-1w74wf02	10	10	and	and	CC
cord-318495-1w74wf02	10	11	survive	survive	VB
cord-318495-1w74wf02	10	12	in	in	IN
cord-318495-1w74wf02	10	13	the	the	DT
cord-318495-1w74wf02	10	14	complex	complex	JJ
cord-318495-1w74wf02	10	15	host	host	NN
cord-318495-1w74wf02	10	16	physiological	physiological	JJ
cord-318495-1w74wf02	10	17	and	and	CC
cord-318495-1w74wf02	10	18	immune	immune	JJ
cord-318495-1w74wf02	10	19	environment	environment	NN
cord-318495-1w74wf02	10	20	.	.	.
cord-318495-1w74wf02	11	1	Accumulating	accumulate	VBG
cord-318495-1w74wf02	11	2	evidence	evidence	NN
cord-318495-1w74wf02	11	3	demonstrates	demonstrate	VBZ
cord-318495-1w74wf02	11	4	that	that	IN
cord-318495-1w74wf02	11	5	viruses	virus	NNS
cord-318495-1w74wf02	11	6	can	can	MD
cord-318495-1w74wf02	11	7	generate	generate	VB
cord-318495-1w74wf02	11	8	modified	modified	JJ
cord-318495-1w74wf02	11	9	forms	form	NNS
cord-318495-1w74wf02	11	10	of	of	IN
cord-318495-1w74wf02	11	11	their	-PRON-	PRP$
cord-318495-1w74wf02	11	12	genome	genome	NN
cord-318495-1w74wf02	11	13	during	during	IN
cord-318495-1w74wf02	11	14	replication	replication	NN
cord-318495-1w74wf02	11	15	as	as	IN
cord-318495-1w74wf02	11	16	tools	tool	NNS
cord-318495-1w74wf02	11	17	to	to	TO
cord-318495-1w74wf02	11	18	adapt	adapt	VB
cord-318495-1w74wf02	11	19	to	to	IN
cord-318495-1w74wf02	11	20	environmental	environmental	JJ
cord-318495-1w74wf02	11	21	challenges	challenge	NNS
cord-318495-1w74wf02	11	22	.	.	.
cord-318495-1w74wf02	12	1	While	while	IN
cord-318495-1w74wf02	12	2	the	the	DT
cord-318495-1w74wf02	12	3	standard	standard	JJ
cord-318495-1w74wf02	12	4	genome	genome	NN
cord-318495-1w74wf02	12	5	encodes	encode	VBZ
cord-318495-1w74wf02	12	6	all	all	PDT
cord-318495-1w74wf02	12	7	the	the	DT
cord-318495-1w74wf02	12	8	viral	viral	JJ
cord-318495-1w74wf02	12	9	proteins	protein	NNS
cord-318495-1w74wf02	12	10	required	require	VBN
cord-318495-1w74wf02	12	11	for	for	IN
cord-318495-1w74wf02	12	12	sustaining	sustain	VBG
cord-318495-1w74wf02	12	13	viral	viral	JJ
cord-318495-1w74wf02	12	14	replication	replication	NN
cord-318495-1w74wf02	12	15	,	,	,
cord-318495-1w74wf02	12	16	viral	viral	JJ
cord-318495-1w74wf02	12	17	variants	variant	NNS
cord-318495-1w74wf02	12	18	contain	contain	VBP
cord-318495-1w74wf02	12	19	random	random	JJ
cord-318495-1w74wf02	12	20	mutations	mutation	NNS
cord-318495-1w74wf02	12	21	that	that	WDT
cord-318495-1w74wf02	12	22	can	can	MD
cord-318495-1w74wf02	12	23	serve	serve	VB
cord-318495-1w74wf02	12	24	to	to	TO
cord-318495-1w74wf02	12	25	enhance	enhance	VB
cord-318495-1w74wf02	12	26	the	the	DT
cord-318495-1w74wf02	12	27	ability	ability	NN
cord-318495-1w74wf02	12	28	of	of	IN
cord-318495-1w74wf02	12	29	the	the	DT
cord-318495-1w74wf02	12	30	virus	virus	NN
cord-318495-1w74wf02	12	31	to	to	TO
cord-318495-1w74wf02	12	32	adapt	adapt	VB
cord-318495-1w74wf02	12	33	to	to	IN
cord-318495-1w74wf02	12	34	new	new	JJ
cord-318495-1w74wf02	12	35	conditions	condition	NNS
cord-318495-1w74wf02	12	36	1	1	CD
cord-318495-1w74wf02	12	37	.	.	.
cord-318495-1w74wf02	13	1	In	in	IN
cord-318495-1w74wf02	13	2	addition	addition	NN
cord-318495-1w74wf02	13	3	,	,	,
cord-318495-1w74wf02	13	4	defective	defective	JJ
cord-318495-1w74wf02	13	5	viral	viral	JJ
cord-318495-1w74wf02	13	6	genomes	genome	NNS
cord-318495-1w74wf02	13	7	(	(	-LRB-
cord-318495-1w74wf02	13	8	DVGs	dvg	NNS
cord-318495-1w74wf02	13	9	)	)	-RRB-
cord-318495-1w74wf02	13	10	and	and	CC
cord-318495-1w74wf02	13	11	an	an	DT
cord-318495-1w74wf02	13	12	expanding	expand	VBG
cord-318495-1w74wf02	13	13	family	family	NN
cord-318495-1w74wf02	13	14	of	of	IN
cord-318495-1w74wf02	13	15	sub	sub	JJ
cord-318495-1w74wf02	13	16	-	-	JJ
cord-318495-1w74wf02	13	17	viral	viral	JJ
cord-318495-1w74wf02	13	18	particles	particle	NNS
cord-318495-1w74wf02	13	19	(	(	-LRB-
cord-318495-1w74wf02	13	20	Box	Box	NNP
cord-318495-1w74wf02	13	21	1	1	CD
cord-318495-1w74wf02	13	22	)	)	-RRB-
cord-318495-1w74wf02	13	23	that	that	WDT
cord-318495-1w74wf02	13	24	result	result	VBP
cord-318495-1w74wf02	13	25	from	from	IN
cord-318495-1w74wf02	13	26	either	either	DT
cord-318495-1w74wf02	13	27	small	small	JJ
cord-318495-1w74wf02	13	28	mutations	mutation	NNS
cord-318495-1w74wf02	13	29	or	or	CC
cord-318495-1w74wf02	13	30	drastic	drastic	JJ
cord-318495-1w74wf02	13	31	truncations	truncation	NNS
cord-318495-1w74wf02	13	32	and	and	CC
cord-318495-1w74wf02	13	33	modifications	modification	NNS
cord-318495-1w74wf02	13	34	of	of	IN
cord-318495-1w74wf02	13	35	the	the	DT
cord-318495-1w74wf02	13	36	viral	viral	JJ
cord-318495-1w74wf02	13	37	genome	genome	NN
cord-318495-1w74wf02	13	38	render	render	VBP
cord-318495-1w74wf02	13	39	the	the	DT
cord-318495-1w74wf02	13	40	virus	virus	NN
cord-318495-1w74wf02	13	41	unable	unable	JJ
cord-318495-1w74wf02	13	42	to	to	TO
cord-318495-1w74wf02	13	43	complete	complete	VB
cord-318495-1w74wf02	13	44	a	a	DT
cord-318495-1w74wf02	13	45	full	full	JJ
cord-318495-1w74wf02	13	46	replication	replication	NN
cord-318495-1w74wf02	13	47	cycle	cycle	NN
cord-318495-1w74wf02	13	48	in	in	IN
cord-318495-1w74wf02	13	49	the	the	DT
cord-318495-1w74wf02	13	50	absence	absence	NN
cord-318495-1w74wf02	13	51	of	of	IN
cord-318495-1w74wf02	13	52	a	a	DT
cord-318495-1w74wf02	13	53	helper	helper	NN
cord-318495-1w74wf02	13	54	full	full	JJ
cord-318495-1w74wf02	13	55	-	-	HYPH
cord-318495-1w74wf02	13	56	length	length	NN
cord-318495-1w74wf02	13	57	virus	virus	NN
cord-318495-1w74wf02	13	58	to	to	TO
cord-318495-1w74wf02	13	59	complement	complement	VB
cord-318495-1w74wf02	13	60	the	the	DT
cord-318495-1w74wf02	13	61	functions	function	NNS
cord-318495-1w74wf02	13	62	lost	lose	VBN
cord-318495-1w74wf02	13	63	.	.	.
cord-318495-1w74wf02	14	1	DVGs	dvg	NNS
cord-318495-1w74wf02	14	2	were	be	VBD
cord-318495-1w74wf02	14	3	identified	identify	VBN
cord-318495-1w74wf02	14	4	by	by	IN
cord-318495-1w74wf02	14	5	Preben	Preben	NNP
cord-318495-1w74wf02	14	6	Von	Von	NNP
cord-318495-1w74wf02	14	7	Magnus	Magnus	NNP
cord-318495-1w74wf02	14	8	in	in	IN
cord-318495-1w74wf02	14	9	the	the	DT
cord-318495-1w74wf02	14	10	late	late	JJ
cord-318495-1w74wf02	14	11	1940s	1940	NNS
cord-318495-1w74wf02	14	12	as	as	IN
cord-318495-1w74wf02	14	13	incomplete	incomplete	JJ
cord-318495-1w74wf02	14	14	influenza	influenza	NN
cord-318495-1w74wf02	14	15	viruses	virus	NNS
cord-318495-1w74wf02	14	16	able	able	JJ
cord-318495-1w74wf02	14	17	to	to	TO
cord-318495-1w74wf02	14	18	interfere	interfere	VB
cord-318495-1w74wf02	14	19	with	with	IN
cord-318495-1w74wf02	14	20	the	the	DT
cord-318495-1w74wf02	14	21	replication	replication	NN
cord-318495-1w74wf02	14	22	of	of	IN
cord-318495-1w74wf02	14	23	the	the	DT
cord-318495-1w74wf02	14	24	wild	wild	JJ
cord-318495-1w74wf02	14	25	-	-	HYPH
cord-318495-1w74wf02	14	26	type	type	NN
cord-318495-1w74wf02	14	27	virus	virus	NN
cord-318495-1w74wf02	14	28	2	2	CD
cord-318495-1w74wf02	14	29	.	.	.
cord-318495-1w74wf02	15	1	More	More	JJR
cord-318495-1w74wf02	15	2	than	than	IN
cord-318495-1w74wf02	15	3	two	two	CD
cord-318495-1w74wf02	15	4	decades	decade	NNS
cord-318495-1w74wf02	15	5	after	after	IN
cord-318495-1w74wf02	15	6	their	-PRON-	PRP$
cord-318495-1w74wf02	15	7	discovery	discovery	NN
cord-318495-1w74wf02	15	8	,	,	,
cord-318495-1w74wf02	15	9	Alice	Alice	NNP
cord-318495-1w74wf02	15	10	Huang	Huang	NNP
cord-318495-1w74wf02	15	11	and	and	CC
cord-318495-1w74wf02	15	12	David	David	NNP
cord-318495-1w74wf02	15	13	Baltimore	Baltimore	NNP
cord-318495-1w74wf02	15	14	coined	coin	VBD
cord-318495-1w74wf02	15	15	the	the	DT
cord-318495-1w74wf02	15	16	term	term	NN
cord-318495-1w74wf02	15	17	defective	defective	JJ
cord-318495-1w74wf02	15	18	interfering	interfere	VBG
cord-318495-1w74wf02	15	19	(	(	-LRB-
cord-318495-1w74wf02	15	20	DI	DI	NNP
cord-318495-1w74wf02	15	21	)	)	-RRB-
cord-318495-1w74wf02	15	22	particles	particle	NNS
cord-318495-1w74wf02	15	23	,	,	,
cord-318495-1w74wf02	15	24	or	or	CC
cord-318495-1w74wf02	15	25	DIPs	dip	NNS
cord-318495-1w74wf02	15	26	,	,	,
cord-318495-1w74wf02	15	27	to	to	TO
cord-318495-1w74wf02	15	28	define	define	VB
cord-318495-1w74wf02	15	29	viral	viral	JJ
cord-318495-1w74wf02	15	30	particles	particle	NNS
cord-318495-1w74wf02	15	31	that	that	WDT
cord-318495-1w74wf02	15	32	contain	contain	VBP
cord-318495-1w74wf02	15	33	normal	normal	JJ
cord-318495-1w74wf02	15	34	structural	structural	JJ
cord-318495-1w74wf02	15	35	proteins	protein	NNS
cord-318495-1w74wf02	15	36	but	but	CC
cord-318495-1w74wf02	15	37	only	only	RB
cord-318495-1w74wf02	15	38	a	a	DT
cord-318495-1w74wf02	15	39	part	part	NN
cord-318495-1w74wf02	15	40	of	of	IN
cord-318495-1w74wf02	15	41	the	the	DT
cord-318495-1w74wf02	15	42	viral	viral	JJ
cord-318495-1w74wf02	15	43	genome	genome	NN
cord-318495-1w74wf02	15	44	.	.	.
cord-318495-1w74wf02	16	1	In	in	IN
cord-318495-1w74wf02	16	2	addition	addition	NN
cord-318495-1w74wf02	16	3	,	,	,
cord-318495-1w74wf02	16	4	they	-PRON-	PRP
cord-318495-1w74wf02	16	5	stipulated	stipulate	VBD
cord-318495-1w74wf02	16	6	that	that	IN
cord-318495-1w74wf02	16	7	DIPs	dip	NNS
cord-318495-1w74wf02	16	8	can	can	MD
cord-318495-1w74wf02	16	9	only	only	RB
cord-318495-1w74wf02	16	10	replicate	replicate	VB
cord-318495-1w74wf02	16	11	in	in	IN
cord-318495-1w74wf02	16	12	the	the	DT
cord-318495-1w74wf02	16	13	presence	presence	NN
cord-318495-1w74wf02	16	14	of	of	IN
cord-318495-1w74wf02	16	15	helper	helper	NN
cord-318495-1w74wf02	16	16	virus	virus	NN
cord-318495-1w74wf02	16	17	and	and	CC
cord-318495-1w74wf02	16	18	that	that	IN
cord-318495-1w74wf02	16	19	they	-PRON-	PRP
cord-318495-1w74wf02	16	20	interfere	interfere	VBP
cord-318495-1w74wf02	16	21	with	with	IN
cord-318495-1w74wf02	16	22	the	the	DT
cord-318495-1w74wf02	16	23	intracellular	intracellular	JJ
cord-318495-1w74wf02	16	24	replication	replication	NN
cord-318495-1w74wf02	16	25	of	of	IN
cord-318495-1w74wf02	16	26	non	non	JJ
cord-318495-1w74wf02	16	27	-	-	JJ
cord-318495-1w74wf02	16	28	defective	defective	JJ
cord-318495-1w74wf02	16	29	homologous	homologous	JJ
cord-318495-1w74wf02	16	30	virus	virus	NN
cord-318495-1w74wf02	16	31	3	3	CD
cord-318495-1w74wf02	16	32	.	.	.
cord-318495-1w74wf02	17	1	Huang	Huang	NNP
cord-318495-1w74wf02	17	2	and	and	CC
cord-318495-1w74wf02	17	3	Baltimore	Baltimore	NNP
cord-318495-1w74wf02	17	4	theorized	theorize	VBD
cord-318495-1w74wf02	17	5	that	that	IN
cord-318495-1w74wf02	17	6	DIPs	dip	NNS
cord-318495-1w74wf02	17	7	play	play	VBP
cord-318495-1w74wf02	17	8	a	a	DT
cord-318495-1w74wf02	17	9	critical	critical	JJ
cord-318495-1w74wf02	17	10	role	role	NN
cord-318495-1w74wf02	17	11	in	in	IN
cord-318495-1w74wf02	17	12	determining	determine	VBG
cord-318495-1w74wf02	17	13	viral	viral	JJ
cord-318495-1w74wf02	17	14	pathogenesis	pathogenesis	NN
cord-318495-1w74wf02	17	15	.	.	.
cord-318495-1w74wf02	18	1	Follow	follow	VB
cord-318495-1w74wf02	18	2	-	-	HYPH
cord-318495-1w74wf02	18	3	up	up	RP
cord-318495-1w74wf02	18	4	studies	study	NNS
cord-318495-1w74wf02	18	5	using	use	VBG
cord-318495-1w74wf02	18	6	viruses	virus	NNS
cord-318495-1w74wf02	18	7	grown	grow	VBN
cord-318495-1w74wf02	18	8	to	to	TO
cord-318495-1w74wf02	18	9	contain	contain	VB
cord-318495-1w74wf02	18	10	either	either	CC
cord-318495-1w74wf02	18	11	a	a	DT
cord-318495-1w74wf02	18	12	large	large	JJ
cord-318495-1w74wf02	18	13	content	content	NN
cord-318495-1w74wf02	18	14	of	of	IN
cord-318495-1w74wf02	18	15	DIPs	dip	NNS
cord-318495-1w74wf02	18	16	,	,	,
cord-318495-1w74wf02	18	17	or	or	CC
cord-318495-1w74wf02	18	18	depleted	deplete	VBN
cord-318495-1w74wf02	18	19	of	of	IN
cord-318495-1w74wf02	18	20	them	-PRON-	PRP
cord-318495-1w74wf02	18	21	,	,	,
cord-318495-1w74wf02	18	22	revealed	reveal	VBD
cord-318495-1w74wf02	18	23	that	that	IN
cord-318495-1w74wf02	18	24	DIPs	dip	NNS
cord-318495-1w74wf02	18	25	reduced	reduce	VBN
cord-318495-1w74wf02	18	26	virulence	virulence	NN
cord-318495-1w74wf02	18	27	in	in	IN
cord-318495-1w74wf02	18	28	vivo	vivo	NNP
cord-318495-1w74wf02	18	29	4	4	CD
cord-318495-1w74wf02	18	30	,	,	,
cord-318495-1w74wf02	18	31	5	5	CD
cord-318495-1w74wf02	18	32	,	,	,
cord-318495-1w74wf02	18	33	induced	induce	VBN
cord-318495-1w74wf02	18	34	high	high	JJ
cord-318495-1w74wf02	18	35	levels	level	NNS
cord-318495-1w74wf02	18	36	of	of	IN
cord-318495-1w74wf02	18	37	interferon	interferon	NN
cord-318495-1w74wf02	18	38	(	(	-LRB-
cord-318495-1w74wf02	18	39	IFN	IFN	NNP
cord-318495-1w74wf02	18	40	)	)	-RRB-
cord-318495-1w74wf02	18	41	during	during	IN
cord-318495-1w74wf02	18	42	infections	infection	NNS
cord-318495-1w74wf02	18	43	in	in	IN
cord-318495-1w74wf02	18	44	vitro	vitro	FW
cord-318495-1w74wf02	18	45	[	[	-LRB-
cord-318495-1w74wf02	18	46	6	6	CD
cord-318495-1w74wf02	18	47	]	]	-RRB-
cord-318495-1w74wf02	18	48	[	[	-LRB-
cord-318495-1w74wf02	18	49	7	7	CD
cord-318495-1w74wf02	18	50	]	]	-RRB-
cord-318495-1w74wf02	18	51	[	[	-LRB-
cord-318495-1w74wf02	18	52	8	8	CD
cord-318495-1w74wf02	18	53	]	]	-RRB-
cord-318495-1w74wf02	18	54	,	,	,
cord-318495-1w74wf02	18	55	and	and	CC
cord-318495-1w74wf02	18	56	promoted	promote	VBD
cord-318495-1w74wf02	18	57	viral	viral	JJ
cord-318495-1w74wf02	18	58	persistence	persistence	NN
cord-318495-1w74wf02	18	59	in	in	IN
cord-318495-1w74wf02	18	60	vitro	vitro	FW
cord-318495-1w74wf02	18	61	[	[	-LRB-
cord-318495-1w74wf02	18	62	9	9	CD
cord-318495-1w74wf02	18	63	]	]	-RRB-
cord-318495-1w74wf02	18	64	[	[	-LRB-
cord-318495-1w74wf02	18	65	10	10	CD
cord-318495-1w74wf02	18	66	]	]	-RRB-
cord-318495-1w74wf02	18	67	[	[	-LRB-
cord-318495-1w74wf02	18	68	11	11	CD
cord-318495-1w74wf02	18	69	]	]	-RRB-
cord-318495-1w74wf02	18	70	[	[	-LRB-
cord-318495-1w74wf02	18	71	12	12	CD
cord-318495-1w74wf02	18	72	]	]	-RRB-
cord-318495-1w74wf02	18	73	[	[	-LRB-
cord-318495-1w74wf02	18	74	13	13	CD
cord-318495-1w74wf02	18	75	]	]	-RRB-
cord-318495-1w74wf02	19	1	[	[	-LRB-
cord-318495-1w74wf02	19	2	14	14	CD
cord-318495-1w74wf02	19	3	]	]	-RRB-
cord-318495-1w74wf02	20	1	[	[	-LRB-
cord-318495-1w74wf02	20	2	15	15	CD
cord-318495-1w74wf02	20	3	]	]	-RRB-
cord-318495-1w74wf02	20	4	[	[	-LRB-
cord-318495-1w74wf02	20	5	16	16	CD
cord-318495-1w74wf02	20	6	]	]	-RRB-
cord-318495-1w74wf02	20	7	and	and	CC
cord-318495-1w74wf02	20	8	in	in	IN
cord-318495-1w74wf02	20	9	vivo	vivo	NNP
cord-318495-1w74wf02	20	10	17	17	CD
cord-318495-1w74wf02	20	11	,	,	,
cord-318495-1w74wf02	20	12	18	18	CD
cord-318495-1w74wf02	20	13	.	.	.
cord-318495-1w74wf02	21	1	However	however	RB
cord-318495-1w74wf02	21	2	,	,	,
cord-318495-1w74wf02	21	3	despite	despite	IN
cord-318495-1w74wf02	21	4	their	-PRON-	PRP$
cord-318495-1w74wf02	21	5	ubiquitous	ubiquitous	JJ
cord-318495-1w74wf02	21	6	presence	presence	NN
cord-318495-1w74wf02	21	7	and	and	CC
cord-318495-1w74wf02	21	8	important	important	JJ
cord-318495-1w74wf02	21	9	functions	function	NNS
cord-318495-1w74wf02	21	10	,	,	,
cord-318495-1w74wf02	21	11	the	the	DT
cord-318495-1w74wf02	21	12	lack	lack	NN
cord-318495-1w74wf02	21	13	of	of	IN
cord-318495-1w74wf02	21	14	appropriate	appropriate	JJ
cord-318495-1w74wf02	21	15	technology	technology	NN
cord-318495-1w74wf02	21	16	to	to	TO
cord-318495-1w74wf02	21	17	identify	identify	VB
cord-318495-1w74wf02	21	18	DIPs	dip	NNS
cord-318495-1w74wf02	21	19	in	in	IN
cord-318495-1w74wf02	21	20	infections	infection	NNS
cord-318495-1w74wf02	21	21	in	in	IN
cord-318495-1w74wf02	21	22	vivo	vivo	NN
cord-318495-1w74wf02	21	23	led	lead	VBD
cord-318495-1w74wf02	21	24	to	to	IN
cord-318495-1w74wf02	21	25	a	a	DT
cord-318495-1w74wf02	21	26	widespread	widespread	JJ
cord-318495-1w74wf02	21	27	belief	belief	NN
cord-318495-1w74wf02	21	28	that	that	IN
cord-318495-1w74wf02	21	29	DIPs	dip	VBZ
cord-318495-1w74wf02	21	30	and	and	CC
cord-318495-1w74wf02	21	31	their	-PRON-	PRP$
cord-318495-1w74wf02	21	32	DVGs	dvg	NNS
cord-318495-1w74wf02	21	33	were	be	VBD
cord-318495-1w74wf02	21	34	largely	largely	RB
cord-318495-1w74wf02	21	35	a	a	DT
cord-318495-1w74wf02	21	36	product	product	NN
cord-318495-1w74wf02	21	37	of	of	IN
cord-318495-1w74wf02	21	38	in	in	FW
cord-318495-1w74wf02	21	39	vitro	vitro	FW
cord-318495-1w74wf02	21	40	virus	virus	NN
cord-318495-1w74wf02	21	41	replication	replication	NN
cord-318495-1w74wf02	21	42	and	and	CC
cord-318495-1w74wf02	21	43	were	be	VBD
cord-318495-1w74wf02	21	44	not	not	RB
cord-318495-1w74wf02	21	45	relevant	relevant	JJ
cord-318495-1w74wf02	21	46	in	in	IN
cord-318495-1w74wf02	21	47	natural	natural	JJ
cord-318495-1w74wf02	21	48	viral	viral	JJ
cord-318495-1w74wf02	21	49	infections	infection	NNS
cord-318495-1w74wf02	21	50	19	19	CD
cord-318495-1w74wf02	21	51	,	,	,
cord-318495-1w74wf02	21	52	20	20	CD
cord-318495-1w74wf02	21	53	.	.	.
cord-318495-1w74wf02	22	1	By	by	IN
cord-318495-1w74wf02	22	2	the	the	DT
cord-318495-1w74wf02	22	3	late	late	JJ
cord-318495-1w74wf02	22	4	1990s	1990	NNS
cord-318495-1w74wf02	22	5	,	,	,
cord-318495-1w74wf02	22	6	the	the	DT
cord-318495-1w74wf02	22	7	study	study	NN
cord-318495-1w74wf02	22	8	of	of	IN
cord-318495-1w74wf02	22	9	DVGs	dvg	NNS
cord-318495-1w74wf02	22	10	had	have	VBD
cord-318495-1w74wf02	22	11	slowed	slow	VBN
cord-318495-1w74wf02	22	12	down	down	RP
cord-318495-1w74wf02	22	13	drastically	drastically	RB
cord-318495-1w74wf02	22	14	and	and	CC
cord-318495-1w74wf02	22	15	was	be	VBD
cord-318495-1w74wf02	22	16	limited	limit	VBN
cord-318495-1w74wf02	22	17	to	to	IN
cord-318495-1w74wf02	22	18	their	-PRON-	PRP$
cord-318495-1w74wf02	22	19	use	use	NN
cord-318495-1w74wf02	22	20	as	as	IN
cord-318495-1w74wf02	22	21	tools	tool	NNS
cord-318495-1w74wf02	22	22	for	for	IN
cord-318495-1w74wf02	22	23	studying	study	VBG
cord-318495-1w74wf02	22	24	viral	viral	JJ
cord-318495-1w74wf02	22	25	replication	replication	NN
cord-318495-1w74wf02	22	26	or	or	CC
cord-318495-1w74wf02	22	27	as	as	IN
cord-318495-1w74wf02	22	28	potential	potential	JJ
cord-318495-1w74wf02	22	29	antivirals	antiviral	NNS
cord-318495-1w74wf02	22	30	.	.	.
cord-318495-1w74wf02	23	1	Today	today	NN
cord-318495-1w74wf02	23	2	,	,	,
cord-318495-1w74wf02	23	3	DVGs	dvg	NNS
cord-318495-1w74wf02	23	4	have	have	VBP
cord-318495-1w74wf02	23	5	been	be	VBN
cord-318495-1w74wf02	23	6	described	describe	VBN
cord-318495-1w74wf02	23	7	in	in	IN
cord-318495-1w74wf02	23	8	most	most	JJS
cord-318495-1w74wf02	23	9	RNA	RNA	NNP
cord-318495-1w74wf02	23	10	viruses	virus	NNS
cord-318495-1w74wf02	23	11	(	(	-LRB-
cord-318495-1w74wf02	23	12	Table	table	NN
cord-318495-1w74wf02	23	13	1	1	CD
cord-318495-1w74wf02	23	14	)	)	-RRB-
cord-318495-1w74wf02	23	15	and	and	CC
cord-318495-1w74wf02	23	16	technological	technological	JJ
cord-318495-1w74wf02	23	17	advances	advance	NNS
cord-318495-1w74wf02	23	18	have	have	VBP
cord-318495-1w74wf02	23	19	contributed	contribute	VBN
cord-318495-1w74wf02	23	20	to	to	IN
cord-318495-1w74wf02	23	21	establishing	establish	VBG
cord-318495-1w74wf02	23	22	their	-PRON-	PRP$
cord-318495-1w74wf02	23	23	role	role	NN
cord-318495-1w74wf02	23	24	as	as	IN
cord-318495-1w74wf02	23	25	de	de	FW
cord-318495-1w74wf02	23	26	facto	facto	FW
cord-318495-1w74wf02	23	27	danger	danger	NN
cord-318495-1w74wf02	23	28	signals	signal	NNS
cord-318495-1w74wf02	23	29	for	for	IN
cord-318495-1w74wf02	23	30	triggering	trigger	VBG
cord-318495-1w74wf02	23	31	of	of	IN
cord-318495-1w74wf02	23	32	antiviral	antiviral	JJ
cord-318495-1w74wf02	23	33	immunity	immunity	NN
cord-318495-1w74wf02	23	34	in	in	IN
cord-318495-1w74wf02	23	35	many	many	JJ
cord-318495-1w74wf02	23	36	infections	infection	NNS
cord-318495-1w74wf02	23	37	.	.	.
cord-318495-1w74wf02	24	1	In	in	IN
cord-318495-1w74wf02	24	2	addition	addition	NN
cord-318495-1w74wf02	24	3	,	,	,
cord-318495-1w74wf02	24	4	we	-PRON-	PRP
cord-318495-1w74wf02	24	5	are	be	VBP
cord-318495-1w74wf02	24	6	beginning	begin	VBG
cord-318495-1w74wf02	24	7	to	to	TO
cord-318495-1w74wf02	24	8	appreciate	appreciate	VB
cord-318495-1w74wf02	24	9	their	-PRON-	PRP$
cord-318495-1w74wf02	24	10	impact	impact	NN
cord-318495-1w74wf02	24	11	on	on	IN
cord-318495-1w74wf02	24	12	the	the	DT
cord-318495-1w74wf02	24	13	clinical	clinical	JJ
cord-318495-1w74wf02	24	14	outcome	outcome	NN
cord-318495-1w74wf02	24	15	of	of	IN
cord-318495-1w74wf02	24	16	natural	natural	JJ
cord-318495-1w74wf02	24	17	infections	infection	NNS
cord-318495-1w74wf02	24	18	and	and	CC
cord-318495-1w74wf02	24	19	on	on	IN
cord-318495-1w74wf02	24	20	the	the	DT
cord-318495-1w74wf02	24	21	evolution	evolution	NN
cord-318495-1w74wf02	24	22	of	of	IN
cord-318495-1w74wf02	24	23	viruses	virus	NNS
cord-318495-1w74wf02	24	24	.	.	.
cord-318495-1w74wf02	25	1	Moreover	moreover	RB
cord-318495-1w74wf02	25	2	,	,	,
cord-318495-1w74wf02	25	3	we	-PRON-	PRP
cord-318495-1w74wf02	25	4	are	be	VBP
cord-318495-1w74wf02	25	5	witnessing	witness	VBG
cord-318495-1w74wf02	25	6	rapid	rapid	JJ
cord-318495-1w74wf02	25	7	advancements	advancement	NNS
cord-318495-1w74wf02	25	8	in	in	IN
cord-318495-1w74wf02	25	9	the	the	DT
cord-318495-1w74wf02	25	10	understanding	understanding	NN
cord-318495-1w74wf02	25	11	of	of	IN
cord-318495-1w74wf02	25	12	the	the	DT
cord-318495-1w74wf02	25	13	molecular	molecular	JJ
cord-318495-1w74wf02	25	14	mechanisms	mechanism	NNS
cord-318495-1w74wf02	25	15	that	that	WDT
cord-318495-1w74wf02	25	16	regulate	regulate	VBP
cord-318495-1w74wf02	25	17	the	the	DT
cord-318495-1w74wf02	25	18	generation	generation	NN
cord-318495-1w74wf02	25	19	of	of	IN
cord-318495-1w74wf02	25	20	DVGs	dvg	NNS
cord-318495-1w74wf02	25	21	and	and	CC
cord-318495-1w74wf02	25	22	those	those	DT
cord-318495-1w74wf02	25	23	explaining	explain	VBG
cord-318495-1w74wf02	25	24	their	-PRON-	PRP$
cord-318495-1w74wf02	25	25	paradoxical	paradoxical	JJ
cord-318495-1w74wf02	25	26	roles	role	NNS
cord-318495-1w74wf02	25	27	in	in	IN
cord-318495-1w74wf02	25	28	promoting	promote	VBG
cord-318495-1w74wf02	25	29	antiviral	antiviral	JJ
cord-318495-1w74wf02	25	30	immunity	immunity	NN
cord-318495-1w74wf02	25	31	and	and	CC
cord-318495-1w74wf02	25	32	viral	viral	JJ
cord-318495-1w74wf02	25	33	persistence	persistence	NN
cord-318495-1w74wf02	25	34	.	.	.
cord-318495-1w74wf02	26	1	Here	here	RB
cord-318495-1w74wf02	26	2	,	,	,
cord-318495-1w74wf02	26	3	we	-PRON-	PRP
cord-318495-1w74wf02	26	4	review	review	VBP
cord-318495-1w74wf02	26	5	evidence	evidence	NN
cord-318495-1w74wf02	26	6	accumulated	accumulate	VBN
cord-318495-1w74wf02	26	7	over	over	IN
cord-318495-1w74wf02	26	8	more	more	JJR
cord-318495-1w74wf02	26	9	than	than	IN
cord-318495-1w74wf02	26	10	half	half	PDT
cord-318495-1w74wf02	26	11	a	a	DT
cord-318495-1w74wf02	26	12	century	century	NN
cord-318495-1w74wf02	26	13	of	of	IN
cord-318495-1w74wf02	26	14	observations	observation	NNS
cord-318495-1w74wf02	26	15	on	on	IN
cord-318495-1w74wf02	26	16	DVG	DVG	NNP
cord-318495-1w74wf02	26	17	generation	generation	NN
cord-318495-1w74wf02	26	18	and	and	CC
cord-318495-1w74wf02	26	19	activity	activity	NN
cord-318495-1w74wf02	26	20	during	during	IN
cord-318495-1w74wf02	26	21	RNA	RNA	NNP
cord-318495-1w74wf02	26	22	virus	virus	NN
cord-318495-1w74wf02	26	23	infections	infection	NNS
cord-318495-1w74wf02	26	24	.	.	.
cord-318495-1w74wf02	27	1	We	-PRON-	PRP
cord-318495-1w74wf02	27	2	highlight	highlight	VBP
cord-318495-1w74wf02	27	3	recent	recent	JJ
cord-318495-1w74wf02	27	4	advances	advance	NNS
cord-318495-1w74wf02	27	5	that	that	WDT
cord-318495-1w74wf02	27	6	illustrate	illustrate	VBP
cord-318495-1w74wf02	27	7	their	-PRON-	PRP$
cord-318495-1w74wf02	27	8	critical	critical	JJ
cord-318495-1w74wf02	27	9	impact	impact	NN
cord-318495-1w74wf02	27	10	on	on	IN
cord-318495-1w74wf02	27	11	viral	viral	JJ
cord-318495-1w74wf02	27	12	dynamics	dynamic	NNS
cord-318495-1w74wf02	27	13	and	and	CC
cord-318495-1w74wf02	27	14	evolution	evolution	NN
cord-318495-1w74wf02	27	15	during	during	IN
cord-318495-1w74wf02	27	16	both	both	CC
cord-318495-1w74wf02	27	17	acute	acute	JJ
cord-318495-1w74wf02	27	18	and	and	CC
cord-318495-1w74wf02	27	19	long	long	JJ
cord-318495-1w74wf02	27	20	-	-	HYPH
cord-318495-1w74wf02	27	21	term	term	NN
cord-318495-1w74wf02	27	22	virus	virus	NN
cord-318495-1w74wf02	27	23	-	-	HYPH
cord-318495-1w74wf02	27	24	host	host	NN
cord-318495-1w74wf02	27	25	interactions	interaction	NNS
cord-318495-1w74wf02	27	26	.	.	.
cord-318495-1w74wf02	28	1	See	see	VB
cord-318495-1w74wf02	28	2	Box	Box	NNP
cord-318495-1w74wf02	28	3	2	2	CD
cord-318495-1w74wf02	28	4	for	for	IN
cord-318495-1w74wf02	28	5	a	a	DT
cord-318495-1w74wf02	28	6	glossary	glossary	NN
cord-318495-1w74wf02	28	7	of	of	IN
cord-318495-1w74wf02	28	8	relevant	relevant	JJ
cord-318495-1w74wf02	28	9	terms	term	NNS
cord-318495-1w74wf02	28	10	.	.	.
cord-318495-1w74wf02	29	1	Different	different	JJ
cord-318495-1w74wf02	29	2	types	type	NNS
cord-318495-1w74wf02	29	3	of	of	IN
cord-318495-1w74wf02	29	4	DVGs	dvg	NNS
cord-318495-1w74wf02	29	5	are	be	VBP
cord-318495-1w74wf02	29	6	defined	define	VBN
cord-318495-1w74wf02	29	7	by	by	IN
cord-318495-1w74wf02	29	8	the	the	DT
cord-318495-1w74wf02	29	9	type	type	NN
cord-318495-1w74wf02	29	10	of	of	IN
cord-318495-1w74wf02	29	11	genomic	genomic	JJ
cord-318495-1w74wf02	29	12	alterations	alteration	NNS
cord-318495-1w74wf02	29	13	present	present	JJ
cord-318495-1w74wf02	29	14	.	.	.
cord-318495-1w74wf02	30	1	Next	next	JJ
cord-318495-1w74wf02	30	2	generation	generation	NN
cord-318495-1w74wf02	30	3	sequencing	sequencing	NN
cord-318495-1w74wf02	30	4	(	(	-LRB-
cord-318495-1w74wf02	30	5	NGS	NGS	NNP
cord-318495-1w74wf02	30	6	)	)	-RRB-
cord-318495-1w74wf02	30	7	has	have	VBZ
cord-318495-1w74wf02	30	8	revealed	reveal	VBN
cord-318495-1w74wf02	30	9	a	a	DT
cord-318495-1w74wf02	30	10	large	large	JJ
cord-318495-1w74wf02	30	11	variety	variety	NN
cord-318495-1w74wf02	30	12	of	of	IN
cord-318495-1w74wf02	30	13	DVG	DVG	NNP
cord-318495-1w74wf02	30	14	species	specie	NNS
cord-318495-1w74wf02	30	15	present	present	JJ
cord-318495-1w74wf02	30	16	in	in	IN
cord-318495-1w74wf02	30	17	some	some	DT
cord-318495-1w74wf02	30	18	infections	infection	NNS
cord-318495-1w74wf02	30	19	,	,	,
cord-318495-1w74wf02	30	20	and	and	CC
cord-318495-1w74wf02	30	21	recent	recent	JJ
cord-318495-1w74wf02	30	22	studies	study	NNS
cord-318495-1w74wf02	30	23	have	have	VBP
cord-318495-1w74wf02	30	24	begun	begin	VBN
cord-318495-1w74wf02	30	25	to	to	TO
cord-318495-1w74wf02	30	26	elucidate	elucidate	VB
cord-318495-1w74wf02	30	27	the	the	DT
cord-318495-1w74wf02	30	28	distinct	distinct	JJ
cord-318495-1w74wf02	30	29	functions	function	NNS
cord-318495-1w74wf02	30	30	of	of	IN
cord-318495-1w74wf02	30	31	these	these	DT
cord-318495-1w74wf02	30	32	different	different	JJ
cord-318495-1w74wf02	30	33	DVGs	dvg	NNS
cord-318495-1w74wf02	30	34	.	.	.
cord-318495-1w74wf02	31	1	Point	point	NN
cord-318495-1w74wf02	31	2	mutations	mutation	NNS
cord-318495-1w74wf02	31	3	,	,	,
cord-318495-1w74wf02	31	4	hypermutations	hypermutation	NNS
cord-318495-1w74wf02	31	5	and	and	CC
cord-318495-1w74wf02	31	6	frame	frame	NN
cord-318495-1w74wf02	31	7	shifts	shift	NNS
cord-318495-1w74wf02	31	8	.	.	.
cord-318495-1w74wf02	32	1	While	while	IN
cord-318495-1w74wf02	32	2	the	the	DT
cord-318495-1w74wf02	32	3	first	first	JJ
cord-318495-1w74wf02	32	4	DVGs	dvg	NNS
cord-318495-1w74wf02	32	5	to	to	TO
cord-318495-1w74wf02	32	6	be	be	VB
cord-318495-1w74wf02	32	7	identified	identify	VBN
cord-318495-1w74wf02	32	8	and	and	CC
cord-318495-1w74wf02	32	9	distinguished	distinguish	VBN
cord-318495-1w74wf02	32	10	from	from	IN
cord-318495-1w74wf02	32	11	the	the	DT
cord-318495-1w74wf02	32	12	wild	wild	JJ
cord-318495-1w74wf02	32	13	-	-	HYPH
cord-318495-1w74wf02	32	14	type	type	NN
cord-318495-1w74wf02	32	15	fulllength	fulllength	NN
cord-318495-1w74wf02	32	16	viral	viral	JJ
cord-318495-1w74wf02	32	17	genome	genome	NN
cord-318495-1w74wf02	32	18	lacked	lack	VBD
cord-318495-1w74wf02	32	19	large	large	JJ
cord-318495-1w74wf02	32	20	parts	part	NNS
cord-318495-1w74wf02	32	21	of	of	IN
cord-318495-1w74wf02	32	22	the	the	DT
cord-318495-1w74wf02	32	23	genome	genome	NN
cord-318495-1w74wf02	32	24	[	[	-LRB-
cord-318495-1w74wf02	32	25	21	21	CD
cord-318495-1w74wf02	32	26	]	]	-RRB-
cord-318495-1w74wf02	32	27	[	[	-LRB-
cord-318495-1w74wf02	32	28	22	22	CD
cord-318495-1w74wf02	32	29	]	]	-RRB-
cord-318495-1w74wf02	32	30	[	[	-LRB-
cord-318495-1w74wf02	32	31	23	23	CD
cord-318495-1w74wf02	32	32	]	]	-RRB-
cord-318495-1w74wf02	33	1	[	[	-LRB-
cord-318495-1w74wf02	33	2	24	24	CD
cord-318495-1w74wf02	33	3	]	]	-RRB-
cord-318495-1w74wf02	34	1	[	[	-LRB-
cord-318495-1w74wf02	34	2	25	25	CD
cord-318495-1w74wf02	34	3	]	]	-RRB-
cord-318495-1w74wf02	34	4	,	,	,
cord-318495-1w74wf02	34	5	there	there	EX
cord-318495-1w74wf02	34	6	are	be	VBP
cord-318495-1w74wf02	34	7	a	a	DT
cord-318495-1w74wf02	34	8	number	number	NN
cord-318495-1w74wf02	34	9	of	of	IN
cord-318495-1w74wf02	34	10	DVG	DVG	NNP
cord-318495-1w74wf02	34	11	types	type	NNS
cord-318495-1w74wf02	34	12	that	that	WDT
cord-318495-1w74wf02	34	13	do	do	VBP
cord-318495-1w74wf02	34	14	not	not	RB
cord-318495-1w74wf02	34	15	involve	involve	VB
cord-318495-1w74wf02	34	16	drastic	drastic	JJ
cord-318495-1w74wf02	34	17	genomic	genomic	JJ
cord-318495-1w74wf02	34	18	alterations	alteration	NNS
cord-318495-1w74wf02	34	19	.	.	.
cord-318495-1w74wf02	35	1	Point	point	NN
cord-318495-1w74wf02	35	2	mutations	mutation	NNS
cord-318495-1w74wf02	35	3	in	in	IN
cord-318495-1w74wf02	35	4	RNA	RNA	NNP
cord-318495-1w74wf02	35	5	viruses	virus	NNS
cord-318495-1w74wf02	35	6	can	can	MD
cord-318495-1w74wf02	35	7	result	result	VB
cord-318495-1w74wf02	35	8	in	in	IN
cord-318495-1w74wf02	35	9	detrimental	detrimental	JJ
cord-318495-1w74wf02	35	10	alterations	alteration	NNS
cord-318495-1w74wf02	35	11	because	because	IN
cord-318495-1w74wf02	35	12	of	of	IN
cord-318495-1w74wf02	35	13	the	the	DT
cord-318495-1w74wf02	35	14	highly	highly	RB
cord-318495-1w74wf02	35	15	constrained	constrained	JJ
cord-318495-1w74wf02	35	16	nature	nature	NN
cord-318495-1w74wf02	35	17	of	of	IN
cord-318495-1w74wf02	35	18	their	-PRON-	PRP$
cord-318495-1w74wf02	35	19	genome	genome	NN
cord-318495-1w74wf02	35	20	organization	organization	NN
cord-318495-1w74wf02	35	21	.	.	.
cord-318495-1w74wf02	36	1	Indeed	indeed	RB
cord-318495-1w74wf02	36	2	,	,	,
cord-318495-1w74wf02	36	3	a	a	DT
cord-318495-1w74wf02	36	4	majority	majority	NN
cord-318495-1w74wf02	36	5	of	of	IN
cord-318495-1w74wf02	36	6	randomly	randomly	RB
cord-318495-1w74wf02	36	7	introduced	introduce	VBN
cord-318495-1w74wf02	36	8	mutations	mutation	NNS
cord-318495-1w74wf02	36	9	are	be	VBP
cord-318495-1w74wf02	36	10	either	either	RB
cord-318495-1w74wf02	36	11	lethal	lethal	JJ
cord-318495-1w74wf02	36	12	or	or	CC
cord-318495-1w74wf02	36	13	confer	confer	VB
cord-318495-1w74wf02	36	14	a	a	DT
cord-318495-1w74wf02	36	15	significant	significant	JJ
cord-318495-1w74wf02	36	16	fitness	fitness	NN
cord-318495-1w74wf02	36	17	cost	cost	NN
cord-318495-1w74wf02	36	18	,	,	,
cord-318495-1w74wf02	36	19	as	as	IN
cord-318495-1w74wf02	36	20	observed	observe	VBN
cord-318495-1w74wf02	36	21	for	for	IN
cord-318495-1w74wf02	36	22	vesicular	vesicular	JJ
cord-318495-1w74wf02	36	23	stomatitis	stomatitis	NN
cord-318495-1w74wf02	36	24	virus	virus	NN
cord-318495-1w74wf02	36	25	(	(	-LRB-
cord-318495-1w74wf02	36	26	VSV	VSV	NNP
cord-318495-1w74wf02	36	27	)	)	-RRB-
cord-318495-1w74wf02	36	28	26	26	CD
cord-318495-1w74wf02	36	29	,	,	,
cord-318495-1w74wf02	36	30	poliovirus	poliovirus	NN
cord-318495-1w74wf02	36	31	27	27	CD
cord-318495-1w74wf02	36	32	and	and	CC
cord-318495-1w74wf02	36	33	influenza	influenza	NN
cord-318495-1w74wf02	36	34	virus	virus	NN
cord-318495-1w74wf02	36	35	28	28	CD
cord-318495-1w74wf02	36	36	.	.	.
cord-318495-1w74wf02	37	1	While	while	IN
cord-318495-1w74wf02	37	2	it	-PRON-	PRP
cord-318495-1w74wf02	37	3	is	be	VBZ
cord-318495-1w74wf02	37	4	inherently	inherently	RB
cord-318495-1w74wf02	37	5	understood	understand	VBN
cord-318495-1w74wf02	37	6	that	that	IN
cord-318495-1w74wf02	37	7	detrimental	detrimental	JJ
cord-318495-1w74wf02	37	8	mutations	mutation	NNS
cord-318495-1w74wf02	37	9	give	give	VBP
cord-318495-1w74wf02	37	10	rise	rise	NN
cord-318495-1w74wf02	37	11	to	to	IN
cord-318495-1w74wf02	37	12	defective	defective	JJ
cord-318495-1w74wf02	37	13	genomes	genome	NNS
cord-318495-1w74wf02	37	14	,	,	,
cord-318495-1w74wf02	37	15	such	such	JJ
cord-318495-1w74wf02	37	16	genome	genome	NN
cord-318495-1w74wf02	37	17	types	type	NNS
cord-318495-1w74wf02	37	18	have	have	VBP
cord-318495-1w74wf02	37	19	historically	historically	RB
cord-318495-1w74wf02	37	20	not	not	RB
cord-318495-1w74wf02	37	21	been	be	VBN
cord-318495-1w74wf02	37	22	considered	consider	VBN
cord-318495-1w74wf02	37	23	DVGs	dvg	NNS
cord-318495-1w74wf02	37	24	.	.	.
cord-318495-1w74wf02	38	1	A	a	DT
cord-318495-1w74wf02	38	2	genome	genome	NN
cord-318495-1w74wf02	38	3	harbouring	harbour	VBG
cord-318495-1w74wf02	38	4	a	a	DT
cord-318495-1w74wf02	38	5	detrimental	detrimental	JJ
cord-318495-1w74wf02	38	6	mutation	mutation	NN
cord-318495-1w74wf02	38	7	in	in	IN
cord-318495-1w74wf02	38	8	a	a	DT
cord-318495-1w74wf02	38	9	structural	structural	JJ
cord-318495-1w74wf02	38	10	protein	protein	NN
cord-318495-1w74wf02	38	11	could	could	MD
cord-318495-1w74wf02	38	12	replicate	replicate	VB
cord-318495-1w74wf02	38	13	,	,	,
cord-318495-1w74wf02	38	14	but	but	CC
cord-318495-1w74wf02	38	15	not	not	RB
cord-318495-1w74wf02	38	16	assemble	assemble	VB
cord-318495-1w74wf02	38	17	properly	properly	RB
cord-318495-1w74wf02	38	18	;	;	:
cord-318495-1w74wf02	38	19	while	while	IN
cord-318495-1w74wf02	38	20	a	a	DT
cord-318495-1w74wf02	38	21	detrimental	detrimental	JJ
cord-318495-1w74wf02	38	22	mutation	mutation	NN
cord-318495-1w74wf02	38	23	in	in	IN
cord-318495-1w74wf02	38	24	the	the	DT
cord-318495-1w74wf02	38	25	replicase	replicase	NN
cord-318495-1w74wf02	38	26	would	would	MD
cord-318495-1w74wf02	38	27	yield	yield	VB
cord-318495-1w74wf02	38	28	a	a	DT
cord-318495-1w74wf02	38	29	genome	genome	NN
cord-318495-1w74wf02	38	30	that	that	WDT
cord-318495-1w74wf02	38	31	can	can	MD
cord-318495-1w74wf02	38	32	produce	produce	VB
cord-318495-1w74wf02	38	33	proper	proper	JJ
cord-318495-1w74wf02	38	34	structural	structural	JJ
cord-318495-1w74wf02	38	35	and	and	CC
cord-318495-1w74wf02	38	36	assembly	assembly	NN
cord-318495-1w74wf02	38	37	proteins	protein	NNS
cord-318495-1w74wf02	38	38	,	,	,
cord-318495-1w74wf02	38	39	but	but	CC
cord-318495-1w74wf02	38	40	could	could	MD
cord-318495-1w74wf02	38	41	not	not	RB
cord-318495-1w74wf02	38	42	replicate	replicate	VB
cord-318495-1w74wf02	38	43	.	.	.
cord-318495-1w74wf02	39	1	Either	either	CC
cord-318495-1w74wf02	39	2	of	of	IN
cord-318495-1w74wf02	39	3	these	these	DT
cord-318495-1w74wf02	39	4	genomes	genome	NNS
cord-318495-1w74wf02	39	5	could	could	MD
cord-318495-1w74wf02	39	6	potentially	potentially	RB
cord-318495-1w74wf02	39	7	hijack	hijack	VB
cord-318495-1w74wf02	39	8	the	the	DT
cord-318495-1w74wf02	39	9	lacking	lacking	NN
cord-318495-1w74wf02	39	10	functions	function	NNS
cord-318495-1w74wf02	39	11	from	from	IN
cord-318495-1w74wf02	39	12	(	(	-LRB-
cord-318495-1w74wf02	39	13	and	and	CC
cord-318495-1w74wf02	39	14	thus	thus	RB
cord-318495-1w74wf02	39	15	,	,	,
cord-318495-1w74wf02	39	16	interfere	interfere	VB
cord-318495-1w74wf02	39	17	with	with	IN
cord-318495-1w74wf02	39	18	)	)	-RRB-
cord-318495-1w74wf02	39	19	a	a	DT
cord-318495-1w74wf02	39	20	fulllength	fulllength	NN
cord-318495-1w74wf02	39	21	co	co	NN
cord-318495-1w74wf02	39	22	-	-	JJ
cord-318495-1w74wf02	39	23	infecting	infect	VBG
cord-318495-1w74wf02	39	24	virus	virus	NN
cord-318495-1w74wf02	39	25	.	.	.
cord-318495-1w74wf02	40	1	Indeed	indeed	RB
cord-318495-1w74wf02	40	2	,	,	,
cord-318495-1w74wf02	40	3	studies	study	NNS
cord-318495-1w74wf02	40	4	where	where	WRB
cord-318495-1w74wf02	40	5	mutation	mutation	NN
cord-318495-1w74wf02	40	6	rates	rate	NNS
cord-318495-1w74wf02	40	7	are	be	VBP
cord-318495-1w74wf02	40	8	increased	increase	VBN
cord-318495-1w74wf02	40	9	to	to	TO
cord-318495-1w74wf02	40	10	perturb	perturb	VB
cord-318495-1w74wf02	40	11	a	a	DT
cord-318495-1w74wf02	40	12	viral	viral	JJ
cord-318495-1w74wf02	40	13	population	population	NN
cord-318495-1w74wf02	40	14	from	from	IN
cord-318495-1w74wf02	40	15	viability	viability	NN
cord-318495-1w74wf02	40	16	to	to	IN
cord-318495-1w74wf02	40	17	non	non	JJ
cord-318495-1w74wf02	40	18	-	-	JJ
cord-318495-1w74wf02	40	19	viability	viability	JJ
cord-318495-1w74wf02	40	20	,	,	,
cord-318495-1w74wf02	40	21	revealed	reveal	VBD
cord-318495-1w74wf02	40	22	that	that	IN
cord-318495-1w74wf02	40	23	the	the	DT
cord-318495-1w74wf02	40	24	defective	defective	JJ
cord-318495-1w74wf02	40	25	RNAs	rna	NNS
cord-318495-1w74wf02	40	26	that	that	WDT
cord-318495-1w74wf02	40	27	appear	appear	VBP
cord-318495-1w74wf02	40	28	prior	prior	RB
cord-318495-1w74wf02	40	29	to	to	IN
cord-318495-1w74wf02	40	30	population	population	NN
cord-318495-1w74wf02	40	31	Marco	Marco	NNP
cord-318495-1w74wf02	40	32	Vignuzzi	Vignuzzi	NNP
cord-318495-1w74wf02	40	33	1	1	CD
cord-318495-1w74wf02	40	34	and	and	CC
cord-318495-1w74wf02	40	35	Carolina	Carolina	NNP
cord-318495-1w74wf02	40	36	B.	B.	NNP
cord-318495-1w74wf02	40	37	López	López	NNP
cord-318495-1w74wf02	40	38	2	2	CD
cord-318495-1w74wf02	41	1	*	*	NFP
cord-318495-1w74wf02	41	2	Viruses	virus	NNS
cord-318495-1w74wf02	41	3	survive	survive	VBP
cord-318495-1w74wf02	41	4	often	often	RB
cord-318495-1w74wf02	41	5	harsh	harsh	JJ
cord-318495-1w74wf02	41	6	host	host	NN
cord-318495-1w74wf02	41	7	environments	environment	NNS
cord-318495-1w74wf02	41	8	,	,	,
cord-318495-1w74wf02	41	9	yet	yet	CC
cord-318495-1w74wf02	41	10	we	-PRON-	PRP
cord-318495-1w74wf02	41	11	know	know	VBP
cord-318495-1w74wf02	41	12	little	little	JJ
cord-318495-1w74wf02	41	13	about	about	IN
cord-318495-1w74wf02	41	14	the	the	DT
cord-318495-1w74wf02	41	15	strategies	strategy	NNS
cord-318495-1w74wf02	41	16	they	-PRON-	PRP
cord-318495-1w74wf02	41	17	utilize	utilize	VBP
cord-318495-1w74wf02	41	18	to	to	TO
cord-318495-1w74wf02	41	19	adapt	adapt	VB
cord-318495-1w74wf02	41	20	and	and	CC
cord-318495-1w74wf02	41	21	subsist	subsist	VB
cord-318495-1w74wf02	42	1	given	give	VBN
cord-318495-1w74wf02	42	2	their	-PRON-	PRP$
cord-318495-1w74wf02	42	3	limited	limited	JJ
cord-318495-1w74wf02	42	4	genomic	genomic	JJ
cord-318495-1w74wf02	42	5	resources	resource	NNS
cord-318495-1w74wf02	42	6	.	.	.
cord-318495-1w74wf02	43	1	We	-PRON-	PRP
cord-318495-1w74wf02	43	2	are	be	VBP
cord-318495-1w74wf02	43	3	beginning	begin	VBG
cord-318495-1w74wf02	43	4	to	to	TO
cord-318495-1w74wf02	43	5	appreciate	appreciate	VB
cord-318495-1w74wf02	43	6	the	the	DT
cord-318495-1w74wf02	43	7	surprising	surprising	JJ
cord-318495-1w74wf02	43	8	versatility	versatility	NN
cord-318495-1w74wf02	43	9	of	of	IN
cord-318495-1w74wf02	43	10	viral	viral	JJ
cord-318495-1w74wf02	43	11	genomes	genome	NNS
cord-318495-1w74wf02	43	12	and	and	CC
cord-318495-1w74wf02	43	13	how	how	WRB
cord-318495-1w74wf02	43	14	replicationcompetent	replicationcompetent	NN
cord-318495-1w74wf02	43	15	and	and	CC
cord-318495-1w74wf02	43	16	-defective	-defective	:
cord-318495-1w74wf02	43	17	virus	virus	NN
cord-318495-1w74wf02	43	18	variants	variant	NNS
cord-318495-1w74wf02	43	19	can	can	MD
cord-318495-1w74wf02	43	20	provide	provide	VB
cord-318495-1w74wf02	43	21	means	mean	NNS
cord-318495-1w74wf02	43	22	for	for	IN
cord-318495-1w74wf02	43	23	adaptation	adaptation	NN
cord-318495-1w74wf02	43	24	,	,	,
cord-318495-1w74wf02	43	25	immune	immune	JJ
cord-318495-1w74wf02	43	26	escape	escape	NN
cord-318495-1w74wf02	43	27	and	and	CC
cord-318495-1w74wf02	43	28	virus	virus	NN
cord-318495-1w74wf02	43	29	perpetuation	perpetuation	NN
cord-318495-1w74wf02	43	30	.	.	.
cord-318495-1w74wf02	44	1	This	this	DT
cord-318495-1w74wf02	44	2	Review	Review	NNP
cord-318495-1w74wf02	44	3	summarizes	summarize	VBZ
cord-318495-1w74wf02	44	4	current	current	JJ
cord-318495-1w74wf02	44	5	knowledge	knowledge	NN
cord-318495-1w74wf02	44	6	of	of	IN
cord-318495-1w74wf02	44	7	the	the	DT
cord-318495-1w74wf02	44	8	types	type	NNS
cord-318495-1w74wf02	44	9	of	of	IN
cord-318495-1w74wf02	44	10	defective	defective	JJ
cord-318495-1w74wf02	44	11	viral	viral	JJ
cord-318495-1w74wf02	44	12	genomes	genome	NNS
cord-318495-1w74wf02	44	13	generated	generate	VBN
cord-318495-1w74wf02	44	14	during	during	IN
cord-318495-1w74wf02	44	15	the	the	DT
cord-318495-1w74wf02	44	16	replication	replication	NN
cord-318495-1w74wf02	44	17	of	of	IN
cord-318495-1w74wf02	44	18	RNA	RNA	NNP
cord-318495-1w74wf02	44	19	viruses	virus	NNS
cord-318495-1w74wf02	44	20	and	and	CC
cord-318495-1w74wf02	44	21	the	the	DT
cord-318495-1w74wf02	44	22	functions	function	NNS
cord-318495-1w74wf02	44	23	that	that	WDT
cord-318495-1w74wf02	44	24	they	-PRON-	PRP
cord-318495-1w74wf02	44	25	carry	carry	VBP
cord-318495-1w74wf02	44	26	out	out	RP
cord-318495-1w74wf02	44	27	.	.	.
cord-318495-1w74wf02	45	1	We	-PRON-	PRP
cord-318495-1w74wf02	45	2	highlight	highlight	VBP
cord-318495-1w74wf02	45	3	the	the	DT
cord-318495-1w74wf02	45	4	universality	universality	NN
cord-318495-1w74wf02	45	5	and	and	CC
cord-318495-1w74wf02	45	6	diversity	diversity	NN
cord-318495-1w74wf02	45	7	of	of	IN
cord-318495-1w74wf02	45	8	defective	defective	JJ
cord-318495-1w74wf02	45	9	viral	viral	JJ
cord-318495-1w74wf02	45	10	genomes	genome	NNS
cord-318495-1w74wf02	45	11	during	during	IN
cord-318495-1w74wf02	45	12	infections	infection	NNS
cord-318495-1w74wf02	45	13	and	and	CC
cord-318495-1w74wf02	45	14	discuss	discuss	VB
cord-318495-1w74wf02	45	15	their	-PRON-	PRP$
cord-318495-1w74wf02	45	16	predicted	predict	VBN
cord-318495-1w74wf02	45	17	role	role	NN
cord-318495-1w74wf02	45	18	in	in	IN
cord-318495-1w74wf02	45	19	maintaining	maintain	VBG
cord-318495-1w74wf02	45	20	a	a	DT
cord-318495-1w74wf02	45	21	fit	fit	JJ
cord-318495-1w74wf02	45	22	virus	virus	NN
cord-318495-1w74wf02	45	23	population	population	NN
cord-318495-1w74wf02	45	24	,	,	,
cord-318495-1w74wf02	45	25	their	-PRON-	PRP$
cord-318495-1w74wf02	45	26	impact	impact	NN
cord-318495-1w74wf02	45	27	on	on	IN
cord-318495-1w74wf02	45	28	human	human	JJ
cord-318495-1w74wf02	45	29	and	and	CC
cord-318495-1w74wf02	45	30	animal	animal	NN
cord-318495-1w74wf02	45	31	health	health	NN
cord-318495-1w74wf02	45	32	,	,	,
cord-318495-1w74wf02	45	33	and	and	CC
cord-318495-1w74wf02	45	34	their	-PRON-	PRP$
cord-318495-1w74wf02	45	35	potential	potential	NN
cord-318495-1w74wf02	45	36	to	to	TO
cord-318495-1w74wf02	45	37	be	be	VB
cord-318495-1w74wf02	45	38	harnessed	harness	VBN
cord-318495-1w74wf02	45	39	as	as	IN
cord-318495-1w74wf02	45	40	antiviral	antiviral	JJ
cord-318495-1w74wf02	45	41	tools	tool	NNS
cord-318495-1w74wf02	45	42	.	.	.
cord-318495-1w74wf02	46	1	DVG	DVG	NNP
cord-318495-1w74wf02	46	2	diversity	diversity	NN
cord-318495-1w74wf02	46	3	during	during	IN
cord-318495-1w74wf02	46	4	infection	infection	NN
cord-318495-1w74wf02	46	5	.	.	.
cord-318495-1w74wf02	47	1	Historically	historically	RB
cord-318495-1w74wf02	47	2	,	,	,
cord-318495-1w74wf02	47	3	it	-PRON-	PRP
cord-318495-1w74wf02	47	4	was	be	VBD
cord-318495-1w74wf02	47	5	thought	think	VBN
cord-318495-1w74wf02	47	6	that	that	IN
cord-318495-1w74wf02	47	7	only	only	RB
cord-318495-1w74wf02	47	8	certain	certain	JJ
cord-318495-1w74wf02	47	9	viruses	virus	NNS
cord-318495-1w74wf02	47	10	generated	generate	VBN
cord-318495-1w74wf02	47	11	DVGs	dvg	NNS
cord-318495-1w74wf02	47	12	and	and	CC
cord-318495-1w74wf02	47	13	that	that	IN
cord-318495-1w74wf02	47	14	only	only	RB
cord-318495-1w74wf02	47	15	one	one	CD
cord-318495-1w74wf02	47	16	or	or	CC
cord-318495-1w74wf02	47	17	a	a	DT
cord-318495-1w74wf02	47	18	few	few	JJ
cord-318495-1w74wf02	47	19	distinct	distinct	JJ
cord-318495-1w74wf02	47	20	DVGs	dvg	NNS
cord-318495-1w74wf02	47	21	existed	exist	VBD
cord-318495-1w74wf02	47	22	for	for	IN
cord-318495-1w74wf02	47	23	any	any	DT
cord-318495-1w74wf02	47	24	given	give	VBN
cord-318495-1w74wf02	47	25	virus	virus	NN
cord-318495-1w74wf02	47	26	.	.	.
cord-318495-1w74wf02	48	1	Most	Most	JJS
cord-318495-1w74wf02	48	2	studies	study	NNS
cord-318495-1w74wf02	48	3	originally	originally	RB
cord-318495-1w74wf02	48	4	relied	rely	VBD
cord-318495-1w74wf02	48	5	on	on	IN
cord-318495-1w74wf02	48	6	high	high	JJ
cord-318495-1w74wf02	48	7	multiplicity	multiplicity	NN
cord-318495-1w74wf02	48	8	of	of	IN
cord-318495-1w74wf02	48	9	infection	infection	NN
cord-318495-1w74wf02	48	10	(	(	-LRB-
cord-318495-1w74wf02	48	11	MOI	MOI	NNP
cord-318495-1w74wf02	48	12	)	)	-RRB-
cord-318495-1w74wf02	48	13	passaging	passaging	NN
cord-318495-1w74wf02	48	14	conditions	condition	NNS
cord-318495-1w74wf02	48	15	that	that	WDT
cord-318495-1w74wf02	48	16	favoured	favour	VBD
cord-318495-1w74wf02	48	17	the	the	DT
cord-318495-1w74wf02	48	18	emergence	emergence	NN
cord-318495-1w74wf02	48	19	of	of	IN
cord-318495-1w74wf02	48	20	larger	large	JJR
cord-318495-1w74wf02	48	21	deletions	deletion	NNS
cord-318495-1w74wf02	48	22	(	(	-LRB-
cord-318495-1w74wf02	48	23	and	and	CC
cord-318495-1w74wf02	48	24	thus	thus	RB
cord-318495-1w74wf02	48	25	,	,	,
cord-318495-1w74wf02	48	26	smaller	small	JJR
cord-318495-1w74wf02	48	27	DVGs	dvg	NNS
cord-318495-1w74wf02	48	28	)	)	-RRB-
cord-318495-1w74wf02	48	29	that	that	WDT
cord-318495-1w74wf02	48	30	could	could	MD
cord-318495-1w74wf02	48	31	rapidly	rapidly	RB
cord-318495-1w74wf02	48	32	outcompete	outcompete	VB
cord-318495-1w74wf02	48	33	the	the	DT
cord-318495-1w74wf02	48	34	longer	long	RBR
cord-318495-1w74wf02	48	35	full	full	JJ
cord-318495-1w74wf02	48	36	-	-	HYPH
cord-318495-1w74wf02	48	37	length	length	NN
cord-318495-1w74wf02	48	38	genomes	genome	NNS
cord-318495-1w74wf02	48	39	owing	owe	VBG
cord-318495-1w74wf02	48	40	to	to	IN
cord-318495-1w74wf02	48	41	reduced	reduce	VBN
cord-318495-1w74wf02	48	42	replication	replication	NN
cord-318495-1w74wf02	48	43	times	time	NNS
cord-318495-1w74wf02	48	44	.	.	.
cord-318495-1w74wf02	49	1	Furthermore	furthermore	RB
cord-318495-1w74wf02	49	2	,	,	,
cord-318495-1w74wf02	49	3	these	these	DT
cord-318495-1w74wf02	49	4	works	work	NNS
cord-318495-1w74wf02	49	5	relied	rely	VBD
cord-318495-1w74wf02	49	6	on	on	IN
cord-318495-1w74wf02	49	7	methods	method	NNS
cord-318495-1w74wf02	49	8	with	with	IN
cord-318495-1w74wf02	49	9	low	low	JJ
cord-318495-1w74wf02	49	10	sensitivity	sensitivity	NN
cord-318495-1w74wf02	49	11	of	of	IN
cord-318495-1w74wf02	49	12	detection	detection	NN
cord-318495-1w74wf02	49	13	(	(	-LRB-
cord-318495-1w74wf02	49	14	such	such	JJ
cord-318495-1w74wf02	49	15	as	as	IN
cord-318495-1w74wf02	49	16	visualization	visualization	NN
cord-318495-1w74wf02	49	17	and	and	CC
cord-318495-1w74wf02	49	18	purification	purification	NN
cord-318495-1w74wf02	49	19	on	on	IN
cord-318495-1w74wf02	49	20	agarose	agarose	JJ
cord-318495-1w74wf02	49	21	gels	gel	NNS
cord-318495-1w74wf02	49	22	)	)	-RRB-
cord-318495-1w74wf02	49	23	that	that	WDT
cord-318495-1w74wf02	49	24	would	would	MD
cord-318495-1w74wf02	49	25	only	only	RB
cord-318495-1w74wf02	49	26	isolate	isolate	VB
cord-318495-1w74wf02	49	27	the	the	DT
cord-318495-1w74wf02	49	28	most	most	RBS
cord-318495-1w74wf02	49	29	abundant	abundant	JJ
cord-318495-1w74wf02	49	30	DVGs	dvg	NNS
cord-318495-1w74wf02	49	31	.	.	.
cord-318495-1w74wf02	50	1	However	however	RB
cord-318495-1w74wf02	50	2	,	,	,
cord-318495-1w74wf02	50	3	evidence	evidence	NN
cord-318495-1w74wf02	50	4	for	for	IN
cord-318495-1w74wf02	50	5	populations	population	NNS
cord-318495-1w74wf02	50	6	of	of	IN
cord-318495-1w74wf02	50	7	distinct	distinct	JJ
cord-318495-1w74wf02	50	8	species	specie	NNS
cord-318495-1w74wf02	50	9	of	of	IN
cord-318495-1w74wf02	50	10	DVGs	dvg	NNS
cord-318495-1w74wf02	50	11	in	in	IN
cord-318495-1w74wf02	50	12	a	a	DT
cord-318495-1w74wf02	50	13	single	single	JJ
cord-318495-1w74wf02	50	14	infection	infection	NN
cord-318495-1w74wf02	50	15	has	have	VBZ
cord-318495-1w74wf02	50	16	been	be	VBN
cord-318495-1w74wf02	50	17	reported	report	VBN
cord-318495-1w74wf02	50	18	since	since	IN
cord-318495-1w74wf02	50	19	the	the	DT
cord-318495-1w74wf02	50	20	1980s	1980s	CD
cord-318495-1w74wf02	50	21	45	45	CD
cord-318495-1w74wf02	50	22	,	,	,
cord-318495-1w74wf02	50	23	47	47	CD
cord-318495-1w74wf02	50	24	.	.	.
cord-318495-1w74wf02	51	1	We	-PRON-	PRP
cord-318495-1w74wf02	51	2	now	now	RB
cord-318495-1w74wf02	51	3	know	know	VBP
cord-318495-1w74wf02	51	4	the	the	DT
cord-318495-1w74wf02	51	5	diversity	diversity	NN
cord-318495-1w74wf02	51	6	of	of	IN
cord-318495-1w74wf02	51	7	DVGs	dvg	NNS
cord-318495-1w74wf02	51	8	to	to	TO
cord-318495-1w74wf02	51	9	be	be	VB
cord-318495-1w74wf02	51	10	much	much	RB
cord-318495-1w74wf02	51	11	larger	large	JJR
cord-318495-1w74wf02	51	12	than	than	IN
cord-318495-1w74wf02	51	13	initially	initially	RB
cord-318495-1w74wf02	51	14	appreciated	appreciate	VBN
cord-318495-1w74wf02	51	15	and	and	CC
cord-318495-1w74wf02	51	16	that	that	IN
cord-318495-1w74wf02	51	17	certain	certain	JJ
cord-318495-1w74wf02	51	18	DVGs	dvg	NNS
cord-318495-1w74wf02	51	19	are	be	VBP
cord-318495-1w74wf02	51	20	better	well	JJR
cord-318495-1w74wf02	51	21	than	than	IN
cord-318495-1w74wf02	51	22	others	other	NNS
cord-318495-1w74wf02	51	23	at	at	IN
cord-318495-1w74wf02	51	24	reaching	reach	VBG
cord-318495-1w74wf02	51	25	high	high	JJ
cord-318495-1w74wf02	51	26	abundance	abundance	NN
cord-318495-1w74wf02	51	27	,	,	,
cord-318495-1w74wf02	51	28	likely	likely	RB
cord-318495-1w74wf02	51	29	by	by	IN
cord-318495-1w74wf02	51	30	retaining	retain	VBG
cord-318495-1w74wf02	51	31	certain	certain	JJ
cord-318495-1w74wf02	51	32	properties	property	NNS
cord-318495-1w74wf02	51	33	that	that	WDT
cord-318495-1w74wf02	51	34	confer	confer	VBP
cord-318495-1w74wf02	51	35	replication	replication	NN
cord-318495-1w74wf02	51	36	advantage	advantage	NN
cord-318495-1w74wf02	51	37	such	such	JJ
cord-318495-1w74wf02	51	38	as	as	IN
cord-318495-1w74wf02	51	39	packaging	packaging	NN
cord-318495-1w74wf02	51	40	signals	signal	NNS
cord-318495-1w74wf02	51	41	and	and	CC
cord-318495-1w74wf02	51	42	replication	replication	NN
cord-318495-1w74wf02	51	43	elements	element	NNS
cord-318495-1w74wf02	51	44	,	,	,
cord-318495-1w74wf02	51	45	or	or	CC
cord-318495-1w74wf02	51	46	by	by	IN
cord-318495-1w74wf02	51	47	acquiring	acquire	VBG
cord-318495-1w74wf02	51	48	the	the	DT
cord-318495-1w74wf02	51	49	ability	ability	NN
cord-318495-1w74wf02	51	50	to	to	TO
cord-318495-1w74wf02	51	51	interfere	interfere	VB
cord-318495-1w74wf02	51	52	with	with	IN
cord-318495-1w74wf02	51	53	the	the	DT
cord-318495-1w74wf02	51	54	replication	replication	NN
cord-318495-1w74wf02	51	55	of	of	IN
cord-318495-1w74wf02	51	56	other	other	JJ
cord-318495-1w74wf02	51	57	variants	variant	NNS
cord-318495-1w74wf02	51	58	.	.	.
cord-318495-1w74wf02	52	1	NGS	NGS	NNP
cord-318495-1w74wf02	52	2	has	have	VBZ
cord-318495-1w74wf02	52	3	revealed	reveal	VBN
cord-318495-1w74wf02	52	4	that	that	IN
cord-318495-1w74wf02	52	5	DVGs	dvg	NNS
cord-318495-1w74wf02	52	6	are	be	VBP
cord-318495-1w74wf02	52	7	present	present	JJ
cord-318495-1w74wf02	52	8	in	in	IN
cord-318495-1w74wf02	52	9	virtually	virtually	RB
cord-318495-1w74wf02	52	10	any	any	DT
cord-318495-1w74wf02	52	11	and	and	CC
cord-318495-1w74wf02	52	12	every	every	DT
cord-318495-1w74wf02	52	13	virus	virus	NN
cord-318495-1w74wf02	52	14	population	population	NN
cord-318495-1w74wf02	52	15	,	,	,
cord-318495-1w74wf02	52	16	and	and	CC
cord-318495-1w74wf02	52	17	that	that	IN
cord-318495-1w74wf02	52	18	the	the	DT
cord-318495-1w74wf02	52	19	diversity	diversity	NN
cord-318495-1w74wf02	52	20	of	of	IN
cord-318495-1w74wf02	52	21	DVGs	dvg	NNS
cord-318495-1w74wf02	52	22	is	be	VBZ
cord-318495-1w74wf02	52	23	immense	immense	JJ
cord-318495-1w74wf02	52	24	;	;	:
cord-318495-1w74wf02	52	25	however	however	RB
cord-318495-1w74wf02	52	26	,	,	,
cord-318495-1w74wf02	52	27	the	the	DT
cord-318495-1w74wf02	52	28	relative	relative	JJ
cord-318495-1w74wf02	52	29	abundance	abundance	NN
cord-318495-1w74wf02	52	30	of	of	IN
cord-318495-1w74wf02	52	31	any	any	DT
cord-318495-1w74wf02	52	32	given	give	VBN
cord-318495-1w74wf02	52	33	deletion	deletion	NN
cord-318495-1w74wf02	52	34	or	or	CC
cord-318495-1w74wf02	52	35	rearrangement	rearrangement	NN
cord-318495-1w74wf02	52	36	varies	vary	VBZ
cord-318495-1w74wf02	52	37	,	,	,
cord-318495-1w74wf02	52	38	likely	likely	RB
cord-318495-1w74wf02	52	39	indicating	indicate	VBG
cord-318495-1w74wf02	52	40	that	that	IN
cord-318495-1w74wf02	52	41	a	a	DT
cord-318495-1w74wf02	52	42	variety	variety	NN
cord-318495-1w74wf02	52	43	of	of	IN
cord-318495-1w74wf02	52	44	factors	factor	NNS
cord-318495-1w74wf02	52	45	drive	drive	VBP
cord-318495-1w74wf02	52	46	DVG	DVG	NNP
cord-318495-1w74wf02	52	47	generation	generation	NN
cord-318495-1w74wf02	52	48	and	and	CC
cord-318495-1w74wf02	52	49	accumulation	accumulation	NN
cord-318495-1w74wf02	52	50	.	.	.
cord-318495-1w74wf02	53	1	The	the	DT
cord-318495-1w74wf02	53	2	use	use	NN
cord-318495-1w74wf02	53	3	of	of	IN
cord-318495-1w74wf02	53	4	single	single	JJ
cord-318495-1w74wf02	53	5	-	-	HYPH
cord-318495-1w74wf02	53	6	cell	cell	NN
cord-318495-1w74wf02	53	7	sequencing	sequencing	NN
cord-318495-1w74wf02	53	8	technology	technology	NN
cord-318495-1w74wf02	53	9	will	will	MD
cord-318495-1w74wf02	53	10	allow	allow	VB
cord-318495-1w74wf02	53	11	precise	precise	JJ
cord-318495-1w74wf02	53	12	quantification	quantification	NN
cord-318495-1w74wf02	53	13	of	of	IN
cord-318495-1w74wf02	53	14	the	the	DT
cord-318495-1w74wf02	53	15	frequency	frequency	NN
cord-318495-1w74wf02	53	16	and	and	CC
cord-318495-1w74wf02	53	17	diversity	diversity	NN
cord-318495-1w74wf02	53	18	of	of	IN
cord-318495-1w74wf02	53	19	DVGs	dvg	NNS
cord-318495-1w74wf02	53	20	in	in	IN
cord-318495-1w74wf02	53	21	an	an	DT
cord-318495-1w74wf02	53	22	infected	infected	JJ
cord-318495-1w74wf02	53	23	cell	cell	NN
cord-318495-1w74wf02	53	24	and	and	CC
cord-318495-1w74wf02	53	25	will	will	MD
cord-318495-1w74wf02	53	26	provide	provide	VB
cord-318495-1w74wf02	53	27	data	datum	NNS
cord-318495-1w74wf02	53	28	on	on	IN
cord-318495-1w74wf02	53	29	the	the	DT
cord-318495-1w74wf02	53	30	distribution	distribution	NN
cord-318495-1w74wf02	53	31	of	of	IN
cord-318495-1w74wf02	53	32	DVG	DVG	NNP
cord-318495-1w74wf02	53	33	variants	variant	NNS
cord-318495-1w74wf02	53	34	among	among	IN
cord-318495-1w74wf02	53	35	a	a	DT
cord-318495-1w74wf02	53	36	cell	cell	NN
cord-318495-1w74wf02	53	37	population	population	NN
cord-318495-1w74wf02	53	38	.	.	.
cord-318495-1w74wf02	54	1	Since	since	IN
cord-318495-1w74wf02	54	2	most	most	JJS
cord-318495-1w74wf02	54	3	NGS	NGS	NNP
cord-318495-1w74wf02	54	4	alignment	alignment	NN
cord-318495-1w74wf02	54	5	tools	tool	NNS
cord-318495-1w74wf02	54	6	filter	filter	VBP
cord-318495-1w74wf02	54	7	out	out	RP
cord-318495-1w74wf02	54	8	reads	read	NNS
cord-318495-1w74wf02	54	9	with	with	IN
cord-318495-1w74wf02	54	10	more	more	JJR
cord-318495-1w74wf02	54	11	than	than	IN
cord-318495-1w74wf02	54	12	two	two	CD
cord-318495-1w74wf02	54	13	mismatches	mismatch	NNS
cord-318495-1w74wf02	54	14	,	,	,
cord-318495-1w74wf02	54	15	reads	read	VBZ
cord-318495-1w74wf02	54	16	corresponding	correspond	VBG
cord-318495-1w74wf02	54	17	to	to	IN
cord-318495-1w74wf02	54	18	deletion	deletion	NN
cord-318495-1w74wf02	54	19	breakpoints	breakpoint	NNS
cord-318495-1w74wf02	54	20	or	or	CC
cord-318495-1w74wf02	54	21	rearrangement	rearrangement	NN
cord-318495-1w74wf02	54	22	junctions	junction	NNS
cord-318495-1w74wf02	54	23	are	be	VBP
cord-318495-1w74wf02	54	24	rejected	reject	VBN
cord-318495-1w74wf02	54	25	from	from	IN
cord-318495-1w74wf02	54	26	a	a	DT
cord-318495-1w74wf02	54	27	typical	typical	JJ
cord-318495-1w74wf02	54	28	virus	virus	NN
cord-318495-1w74wf02	54	29	genome	genome	NN
cord-318495-1w74wf02	54	30	alignment	alignment	NN
cord-318495-1w74wf02	54	31	.	.	.
cord-318495-1w74wf02	55	1	A	a	DT
cord-318495-1w74wf02	55	2	re	re	NN
cord-318495-1w74wf02	55	3	-	-	NN
cord-318495-1w74wf02	55	4	analysis	analysis	NN
cord-318495-1w74wf02	55	5	of	of	IN
cord-318495-1w74wf02	55	6	rejected	reject	VBN
cord-318495-1w74wf02	55	7	reads	read	NNS
cord-318495-1w74wf02	55	8	would	would	MD
cord-318495-1w74wf02	55	9	identify	identify	VB
cord-318495-1w74wf02	55	10	these	these	DT
cord-318495-1w74wf02	55	11	DVG	DVG	NNP
cord-318495-1w74wf02	55	12	hallmarks	hallmark	NNS
cord-318495-1w74wf02	55	13	.	.	.
cord-318495-1w74wf02	56	1	With	with	IN
cord-318495-1w74wf02	56	2	growing	grow	VBG
cord-318495-1w74wf02	56	3	interest	interest	NN
cord-318495-1w74wf02	56	4	in	in	IN
cord-318495-1w74wf02	56	5	this	this	DT
cord-318495-1w74wf02	56	6	neglected	neglected	JJ
cord-318495-1w74wf02	56	7	part	part	NN
cord-318495-1w74wf02	56	8	of	of	IN
cord-318495-1w74wf02	56	9	the	the	DT
cord-318495-1w74wf02	56	10	viral	viral	JJ
cord-318495-1w74wf02	56	11	population	population	NN
cord-318495-1w74wf02	56	12	,	,	,
cord-318495-1w74wf02	56	13	informatics	informatics	NN
cord-318495-1w74wf02	56	14	tools	tool	NNS
cord-318495-1w74wf02	56	15	such	such	JJ
cord-318495-1w74wf02	56	16	as	as	IN
cord-318495-1w74wf02	56	17	ViReMa	ViReMa	NNP
cord-318495-1w74wf02	56	18	48	48	CD
cord-318495-1w74wf02	56	19	,	,	,
cord-318495-1w74wf02	56	20	DI	DI	NNP
cord-318495-1w74wf02	56	21	-	-	HYPH
cord-318495-1w74wf02	56	22	tector	tector	NN
cord-318495-1w74wf02	56	23	49	49	CD
cord-318495-1w74wf02	56	24	and	and	CC
cord-318495-1w74wf02	56	25	VODKA	vodka	NN
cord-318495-1w74wf02	56	26	50	50	CD
cord-318495-1w74wf02	56	27	are	be	VBP
cord-318495-1w74wf02	56	28	emerging	emerge	VBG
cord-318495-1w74wf02	56	29	.	.	.
cord-318495-1w74wf02	57	1	These	these	DT
cord-318495-1w74wf02	57	2	tools	tool	NNS
cord-318495-1w74wf02	57	3	re	re	VBP
cord-318495-1w74wf02	57	4	-	-	VB
cord-318495-1w74wf02	57	5	examine	examine	VB
cord-318495-1w74wf02	57	6	reads	read	NNS
cord-318495-1w74wf02	57	7	that	that	IN
cord-318495-1w74wf02	57	8	potentially	potentially	RB
cord-318495-1w74wf02	57	9	harbour	harbour	VBP
cord-318495-1w74wf02	57	10	jumbled	jumbled	JJ
cord-318495-1w74wf02	57	11	or	or	CC
cord-318495-1w74wf02	57	12	rearranged	rearrange	VBN
cord-318495-1w74wf02	57	13	viral	viral	JJ
cord-318495-1w74wf02	57	14	sequences	sequence	NNS
cord-318495-1w74wf02	57	15	and	and	CC
cord-318495-1w74wf02	57	16	have	have	VBP
cord-318495-1w74wf02	57	17	enabled	enable	VBN
cord-318495-1w74wf02	57	18	a	a	DT
cord-318495-1w74wf02	57	19	broader	broad	JJR
cord-318495-1w74wf02	57	20	appreciation	appreciation	NN
cord-318495-1w74wf02	57	21	of	of	IN
cord-318495-1w74wf02	57	22	DVG	DVG	NNP
cord-318495-1w74wf02	57	23	diversity	diversity	NN
cord-318495-1w74wf02	57	24	.	.	.
cord-318495-1w74wf02	58	1	A	a	DT
cord-318495-1w74wf02	58	2	current	current	JJ
cord-318495-1w74wf02	58	3	challenge	challenge	NN
cord-318495-1w74wf02	58	4	with	with	IN
cord-318495-1w74wf02	58	5	NGS	NGS	NNP
cord-318495-1w74wf02	58	6	data	data	NN
cord-318495-1w74wf02	58	7	is	be	VBZ
cord-318495-1w74wf02	58	8	to	to	TO
cord-318495-1w74wf02	58	9	determine	determine	VB
cord-318495-1w74wf02	58	10	how	how	WRB
cord-318495-1w74wf02	58	11	best	good	JJS
cord-318495-1w74wf02	58	12	to	to	TO
cord-318495-1w74wf02	58	13	differentiate	differentiate	VB
cord-318495-1w74wf02	58	14	between	between	IN
cord-318495-1w74wf02	58	15	true	true	JJ
cord-318495-1w74wf02	58	16	DVGs	dvg	NNS
cord-318495-1w74wf02	58	17	and	and	CC
cord-318495-1w74wf02	58	18	background	background	NN
cord-318495-1w74wf02	58	19	error	error	NN
cord-318495-1w74wf02	58	20	of	of	IN
cord-318495-1w74wf02	58	21	NGS	NGS	NNP
cord-318495-1w74wf02	58	22	,	,	,
cord-318495-1w74wf02	58	23	how	how	WRB
cord-318495-1w74wf02	58	24	to	to	TO
cord-318495-1w74wf02	58	25	quantify	quantify	VB
cord-318495-1w74wf02	58	26	the	the	DT
cord-318495-1w74wf02	58	27	relative	relative	JJ
cord-318495-1w74wf02	58	28	abundance	abundance	NN
cord-318495-1w74wf02	58	29	of	of	IN
cord-318495-1w74wf02	58	30	any	any	DT
cord-318495-1w74wf02	58	31	given	give	VBN
cord-318495-1w74wf02	58	32	DVG	DVG	NNP
cord-318495-1w74wf02	58	33	with	with	IN
cord-318495-1w74wf02	58	34	respect	respect	NN
cord-318495-1w74wf02	58	35	to	to	IN
cord-318495-1w74wf02	58	36	full	full	JJ
cord-318495-1w74wf02	58	37	-	-	HYPH
cord-318495-1w74wf02	58	38	length	length	NN
cord-318495-1w74wf02	59	1	In	in	IN
cord-318495-1w74wf02	59	2	addition	addition	NN
cord-318495-1w74wf02	59	3	to	to	IN
cord-318495-1w74wf02	59	4	DVGs	dvg	NNS
cord-318495-1w74wf02	59	5	,	,	,
cord-318495-1w74wf02	59	6	a	a	DT
cord-318495-1w74wf02	59	7	growing	grow	VBG
cord-318495-1w74wf02	59	8	number	number	NN
cord-318495-1w74wf02	59	9	of	of	IN
cord-318495-1w74wf02	59	10	viral	viral	JJ
cord-318495-1w74wf02	59	11	particle	particle	NN
cord-318495-1w74wf02	59	12	variants	variant	NNS
cord-318495-1w74wf02	59	13	and	and	CC
cord-318495-1w74wf02	59	14	sub	sub	JJ
cord-318495-1w74wf02	59	15	-	-	JJ
cord-318495-1w74wf02	59	16	viral	viral	JJ
cord-318495-1w74wf02	59	17	agents	agent	NNS
cord-318495-1w74wf02	59	18	have	have	VBP
cord-318495-1w74wf02	59	19	been	be	VBN
cord-318495-1w74wf02	59	20	discovered	discover	VBN
cord-318495-1w74wf02	59	21	in	in	IN
cord-318495-1w74wf02	59	22	viruses	virus	NNS
cord-318495-1w74wf02	59	23	of	of	IN
cord-318495-1w74wf02	59	24	plants	plant	NNS
cord-318495-1w74wf02	59	25	,	,	,
cord-318495-1w74wf02	59	26	arthropods	arthropod	NNS
cord-318495-1w74wf02	59	27	and	and	CC
cord-318495-1w74wf02	59	28	mammals	mammal	NNS
cord-318495-1w74wf02	59	29	.	.	.
cord-318495-1w74wf02	60	1	These	these	DT
cord-318495-1w74wf02	60	2	include	include	VBP
cord-318495-1w74wf02	60	3	viroids	viroid	NNS
cord-318495-1w74wf02	60	4	,	,	,
cord-318495-1w74wf02	60	5	satellite	satellite	NN
cord-318495-1w74wf02	60	6	viruses	virus	NNS
cord-318495-1w74wf02	60	7	,	,	,
cord-318495-1w74wf02	60	8	virophages	virophage	NNS
cord-318495-1w74wf02	60	9	and	and	CC
cord-318495-1w74wf02	60	10	viral	viral	JJ
cord-318495-1w74wf02	60	11	-	-	HYPH
cord-318495-1w74wf02	60	12	like	like	JJ
cord-318495-1w74wf02	60	13	extracellular	extracellular	JJ
cord-318495-1w74wf02	60	14	vesicles	vesicle	NNS
cord-318495-1w74wf02	60	15	(	(	-LRB-
cord-318495-1w74wf02	60	16	VLVs	VLVs	NNP
cord-318495-1w74wf02	60	17	)	)	-RRB-
cord-318495-1w74wf02	60	18	.	.	.
cord-318495-1w74wf02	61	1	The	the	DT
cord-318495-1w74wf02	61	2	definition	definition	NN
cord-318495-1w74wf02	61	3	of	of	IN
cord-318495-1w74wf02	61	4	these	these	DT
cord-318495-1w74wf02	61	5	entities	entity	NNS
cord-318495-1w74wf02	61	6	seems	seem	VBZ
cord-318495-1w74wf02	61	7	,	,	,
cord-318495-1w74wf02	61	8	at	at	IN
cord-318495-1w74wf02	61	9	times	time	NNS
cord-318495-1w74wf02	61	10	,	,	,
cord-318495-1w74wf02	61	11	blurry	blurry	JJ
cord-318495-1w74wf02	61	12	,	,	,
cord-318495-1w74wf02	61	13	due	due	IN
cord-318495-1w74wf02	61	14	to	to	IN
cord-318495-1w74wf02	61	15	their	-PRON-	PRP$
cord-318495-1w74wf02	61	16	largely	largely	RB
cord-318495-1w74wf02	61	17	intersecting	intersecting	JJ
cord-318495-1w74wf02	61	18	properties	property	NNS
cord-318495-1w74wf02	61	19	.	.	.
cord-318495-1w74wf02	62	1	In	in	IN
cord-318495-1w74wf02	62	2	general	general	JJ
cord-318495-1w74wf02	62	3	,	,	,
cord-318495-1w74wf02	62	4	sub	sub	JJ
cord-318495-1w74wf02	62	5	-	-	JJ
cord-318495-1w74wf02	62	6	viral	viral	JJ
cord-318495-1w74wf02	62	7	agents	agent	NNS
cord-318495-1w74wf02	62	8	,	,	,
cord-318495-1w74wf02	62	9	similar	similar	JJ
cord-318495-1w74wf02	62	10	to	to	IN
cord-318495-1w74wf02	62	11	DVGs	dvg	NNS
cord-318495-1w74wf02	62	12	,	,	,
cord-318495-1w74wf02	62	13	depend	depend	VB
cord-318495-1w74wf02	62	14	on	on	IN
cord-318495-1w74wf02	62	15	complementation	complementation	NN
cord-318495-1w74wf02	62	16	with	with	IN
cord-318495-1w74wf02	62	17	the	the	DT
cord-318495-1w74wf02	62	18	standard	standard	JJ
cord-318495-1w74wf02	62	19	virus	virus	NN
cord-318495-1w74wf02	62	20	to	to	TO
cord-318495-1w74wf02	62	21	replicate	replicate	VB
cord-318495-1w74wf02	62	22	and	and	CC
cord-318495-1w74wf02	62	23	spread	spread	VB
cord-318495-1w74wf02	62	24	.	.	.
cord-318495-1w74wf02	63	1	However	however	RB
cord-318495-1w74wf02	63	2	,	,	,
cord-318495-1w74wf02	63	3	differences	difference	NNS
cord-318495-1w74wf02	63	4	in	in	IN
cord-318495-1w74wf02	63	5	their	-PRON-	PRP$
cord-318495-1w74wf02	63	6	requirements	requirement	NNS
cord-318495-1w74wf02	63	7	for	for	IN
cord-318495-1w74wf02	63	8	complementation	complementation	NN
cord-318495-1w74wf02	63	9	,	,	,
cord-318495-1w74wf02	63	10	target	target	NN
cord-318495-1w74wf02	63	11	virus	virus	NN
cord-318495-1w74wf02	63	12	and	and	CC
cord-318495-1w74wf02	63	13	sequence	sequence	NN
cord-318495-1w74wf02	63	14	identity	identity	NN
cord-318495-1w74wf02	63	15	with	with	IN
cord-318495-1w74wf02	63	16	their	-PRON-	PRP$
cord-318495-1w74wf02	63	17	helper	helper	NN
cord-318495-1w74wf02	63	18	virus	virus	NN
cord-318495-1w74wf02	63	19	are	be	VBP
cord-318495-1w74wf02	63	20	used	use	VBN
cord-318495-1w74wf02	63	21	to	to	TO
cord-318495-1w74wf02	63	22	sub	sub	VB
cord-318495-1w74wf02	63	23	-	-	JJ
cord-318495-1w74wf02	63	24	classify	classify	VB
cord-318495-1w74wf02	63	25	them	-PRON-	PRP
cord-318495-1w74wf02	63	26	.	.	.
cord-318495-1w74wf02	64	1	Here	here	RB
cord-318495-1w74wf02	64	2	,	,	,
cord-318495-1w74wf02	64	3	we	-PRON-	PRP
cord-318495-1w74wf02	64	4	provide	provide	VBP
cord-318495-1w74wf02	64	5	current	current	JJ
cord-318495-1w74wf02	64	6	definitions	definition	NNS
cord-318495-1w74wf02	64	7	of	of	IN
cord-318495-1w74wf02	64	8	these	these	DT
cord-318495-1w74wf02	64	9	sub	sub	JJ
cord-318495-1w74wf02	64	10	-	-	JJ
cord-318495-1w74wf02	64	11	viral	viral	JJ
cord-318495-1w74wf02	64	12	entities	entity	NNS
cord-318495-1w74wf02	64	13	and	and	CC
cord-318495-1w74wf02	64	14	highlight	highlight	VB
cord-318495-1w74wf02	64	15	those	those	DT
cord-318495-1w74wf02	64	16	aspects	aspect	NNS
cord-318495-1w74wf02	64	17	that	that	WDT
cord-318495-1w74wf02	64	18	differentiate	differentiate	VBP
cord-318495-1w74wf02	64	19	them	-PRON-	PRP
cord-318495-1w74wf02	64	20	from	from	IN
cord-318495-1w74wf02	64	21	DIPs	dip	NNS
cord-318495-1w74wf02	64	22	and	and	CC
cord-318495-1w74wf02	64	23	their	-PRON-	PRP$
cord-318495-1w74wf02	64	24	DVGs	dvg	NNS
cord-318495-1w74wf02	64	25	.	.	.
cord-318495-1w74wf02	65	1	Satellite	satellite	NN
cord-318495-1w74wf02	65	2	viruses	virus	NNS
cord-318495-1w74wf02	65	3	were	be	VBD
cord-318495-1w74wf02	65	4	originally	originally	RB
cord-318495-1w74wf02	65	5	described	describe	VBN
cord-318495-1w74wf02	65	6	in	in	IN
cord-318495-1w74wf02	65	7	plant	plant	NN
cord-318495-1w74wf02	65	8	viruses	virus	NNS
cord-318495-1w74wf02	65	9	as	as	IN
cord-318495-1w74wf02	65	10	linear	linear	JJ
cord-318495-1w74wf02	65	11	or	or	CC
cord-318495-1w74wf02	65	12	circular	circular	JJ
cord-318495-1w74wf02	65	13	RNAs	rna	NNS
cord-318495-1w74wf02	65	14	(	(	-LRB-
cord-318495-1w74wf02	65	15	200	200	CD
cord-318495-1w74wf02	65	16	-	-	SYM
cord-318495-1w74wf02	65	17	1,800	1,800	CD
cord-318495-1w74wf02	65	18	nt	nt	RB
cord-318495-1w74wf02	65	19	long	long	RB
cord-318495-1w74wf02	65	20	)	)	-RRB-
cord-318495-1w74wf02	65	21	that	that	WDT
cord-318495-1w74wf02	65	22	require	require	VBP
cord-318495-1w74wf02	65	23	a	a	DT
cord-318495-1w74wf02	65	24	helper	helper	NN
cord-318495-1w74wf02	65	25	virus	virus	NN
cord-318495-1w74wf02	65	26	to	to	TO
cord-318495-1w74wf02	65	27	propagate	propagate	VB
cord-318495-1w74wf02	65	28	but	but	CC
cord-318495-1w74wf02	65	29	are	be	VBP
cord-318495-1w74wf02	65	30	unrelated	unrelated	JJ
cord-318495-1w74wf02	65	31	in	in	IN
cord-318495-1w74wf02	65	32	sequence	sequence	NN
cord-318495-1w74wf02	65	33	to	to	IN
cord-318495-1w74wf02	65	34	the	the	DT
cord-318495-1w74wf02	65	35	helper	helper	NN
cord-318495-1w74wf02	65	36	virus	virus	NN
cord-318495-1w74wf02	65	37	.	.	.
cord-318495-1w74wf02	66	1	Satellite	satellite	NN
cord-318495-1w74wf02	66	2	viruses	virus	NNS
cord-318495-1w74wf02	66	3	are	be	VBP
cord-318495-1w74wf02	66	4	generally	generally	RB
cord-318495-1w74wf02	66	5	dispensable	dispensable	JJ
cord-318495-1w74wf02	66	6	for	for	IN
cord-318495-1w74wf02	66	7	the	the	DT
cord-318495-1w74wf02	66	8	replication	replication	NN
cord-318495-1w74wf02	66	9	of	of	IN
cord-318495-1w74wf02	66	10	the	the	DT
cord-318495-1w74wf02	66	11	helper	helper	NN
cord-318495-1w74wf02	66	12	virus	virus	NN
cord-318495-1w74wf02	66	13	,	,	,
cord-318495-1w74wf02	66	14	with	with	IN
cord-318495-1w74wf02	66	15	some	some	DT
cord-318495-1w74wf02	66	16	exceptions	exception	NNS
cord-318495-1w74wf02	66	17	192	192	CD
cord-318495-1w74wf02	66	18	,	,	,
cord-318495-1w74wf02	66	19	193	193	CD
cord-318495-1w74wf02	66	20	.	.	.
cord-318495-1w74wf02	67	1	Satellite	satellite	NN
cord-318495-1w74wf02	67	2	viruses	virus	NNS
cord-318495-1w74wf02	67	3	differ	differ	VBP
cord-318495-1w74wf02	67	4	from	from	IN
cord-318495-1w74wf02	67	5	satellite	satellite	NN
cord-318495-1w74wf02	67	6	RNAs	rna	NNS
cord-318495-1w74wf02	67	7	in	in	IN
cord-318495-1w74wf02	67	8	that	that	IN
cord-318495-1w74wf02	67	9	they	-PRON-	PRP
cord-318495-1w74wf02	67	10	encode	encode	VBP
cord-318495-1w74wf02	67	11	a	a	DT
cord-318495-1w74wf02	67	12	protein	protein	NN
cord-318495-1w74wf02	67	13	that	that	WDT
cord-318495-1w74wf02	67	14	packages	package	VBZ
cord-318495-1w74wf02	67	15	the	the	DT
cord-318495-1w74wf02	67	16	satellite	satellite	NN
cord-318495-1w74wf02	67	17	RNA	RNA	NNP
cord-318495-1w74wf02	67	18	into	into	IN
cord-318495-1w74wf02	67	19	virions	virion	NNS
cord-318495-1w74wf02	67	20	.	.	.
cord-318495-1w74wf02	68	1	Satellite	satellite	NN
cord-318495-1w74wf02	68	2	RNAs	rna	NNS
cord-318495-1w74wf02	68	3	can	can	MD
cord-318495-1w74wf02	68	4	interfere	interfere	VB
cord-318495-1w74wf02	68	5	with	with	IN
cord-318495-1w74wf02	68	6	the	the	DT
cord-318495-1w74wf02	68	7	replication	replication	NN
cord-318495-1w74wf02	68	8	of	of	IN
cord-318495-1w74wf02	68	9	its	-PRON-	PRP$
cord-318495-1w74wf02	68	10	helper	helper	NN
cord-318495-1w74wf02	68	11	virus	virus	NN
cord-318495-1w74wf02	68	12	and	and	CC
cord-318495-1w74wf02	68	13	either	either	CC
cord-318495-1w74wf02	68	14	attenuate	attenuate	VB
cord-318495-1w74wf02	68	15	or	or	CC
cord-318495-1w74wf02	68	16	exacerbate	exacerbate	VB
cord-318495-1w74wf02	68	17	disease	disease	NN
cord-318495-1w74wf02	68	18	.	.	.
cord-318495-1w74wf02	69	1	An	an	DT
cord-318495-1w74wf02	69	2	example	example	NN
cord-318495-1w74wf02	69	3	of	of	IN
cord-318495-1w74wf02	69	4	a	a	DT
cord-318495-1w74wf02	69	5	satellite	satellite	NN
cord-318495-1w74wf02	69	6	virus	virus	NN
cord-318495-1w74wf02	69	7	is	be	VBZ
cord-318495-1w74wf02	69	8	the	the	DT
cord-318495-1w74wf02	69	9	satellite	satellite	NN
cord-318495-1w74wf02	69	10	tobacco	tobacco	NN
cord-318495-1w74wf02	69	11	necrosis	necrosis	NN
cord-318495-1w74wf02	69	12	virus	virus	NN
cord-318495-1w74wf02	69	13	194	194	CD
cord-318495-1w74wf02	69	14	.	.	.
cord-318495-1w74wf02	70	1	This	this	DT
cord-318495-1w74wf02	70	2	positive	positive	JJ
cord-318495-1w74wf02	70	3	-	-	HYPH
cord-318495-1w74wf02	70	4	sense	sense	NN
cord-318495-1w74wf02	70	5	,	,	,
cord-318495-1w74wf02	70	6	singlestranded	singlestranded	NNP
cord-318495-1w74wf02	70	7	RNA	RNA	NNP
cord-318495-1w74wf02	70	8	satellite	satellite	NN
cord-318495-1w74wf02	70	9	virus	virus	NN
cord-318495-1w74wf02	70	10	suppresses	suppress	VBZ
cord-318495-1w74wf02	70	11	the	the	DT
cord-318495-1w74wf02	70	12	replication	replication	NN
cord-318495-1w74wf02	70	13	of	of	IN
cord-318495-1w74wf02	70	14	its	-PRON-	PRP$
cord-318495-1w74wf02	70	15	helper	helper	NN
cord-318495-1w74wf02	70	16	virus	virus	NN
cord-318495-1w74wf02	70	17	and	and	CC
cord-318495-1w74wf02	70	18	ameliorates	ameliorate	VBZ
cord-318495-1w74wf02	70	19	tobacco	tobacco	NN
cord-318495-1w74wf02	70	20	necrosis	necrosis	NN
cord-318495-1w74wf02	70	21	virus	virus	NN
cord-318495-1w74wf02	70	22	symptoms	symptom	VBZ
cord-318495-1w74wf02	70	23	195	195	CD
cord-318495-1w74wf02	70	24	.	.	.
cord-318495-1w74wf02	71	1	Viroids	viroid	NNS
cord-318495-1w74wf02	71	2	differ	differ	VBP
cord-318495-1w74wf02	71	3	from	from	IN
cord-318495-1w74wf02	71	4	satellite	satellite	NN
cord-318495-1w74wf02	71	5	viruses	virus	NNS
cord-318495-1w74wf02	71	6	in	in	IN
cord-318495-1w74wf02	71	7	that	that	IN
cord-318495-1w74wf02	71	8	they	-PRON-	PRP
cord-318495-1w74wf02	71	9	do	do	VBP
cord-318495-1w74wf02	71	10	not	not	RB
cord-318495-1w74wf02	71	11	encode	encode	VB
cord-318495-1w74wf02	71	12	any	any	DT
cord-318495-1w74wf02	71	13	protein	protein	NN
cord-318495-1w74wf02	71	14	,	,	,
cord-318495-1w74wf02	71	15	do	do	VBP
cord-318495-1w74wf02	71	16	not	not	RB
cord-318495-1w74wf02	71	17	require	require	VB
cord-318495-1w74wf02	71	18	helper	helper	NN
cord-318495-1w74wf02	71	19	virus	virus	NN
cord-318495-1w74wf02	71	20	for	for	IN
cord-318495-1w74wf02	71	21	replication	replication	NN
cord-318495-1w74wf02	71	22	,	,	,
cord-318495-1w74wf02	71	23	and	and	CC
cord-318495-1w74wf02	71	24	are	be	VBP
cord-318495-1w74wf02	71	25	not	not	RB
cord-318495-1w74wf02	71	26	encapsidated	encapsidate	VBN
cord-318495-1w74wf02	71	27	.	.	.
cord-318495-1w74wf02	72	1	Viroids	Viroids	NNP
cord-318495-1w74wf02	72	2	have	have	VBP
cord-318495-1w74wf02	72	3	a	a	DT
cord-318495-1w74wf02	72	4	circular	circular	JJ
cord-318495-1w74wf02	72	5	RNA	RNA	NNP
cord-318495-1w74wf02	72	6	genome	genome	NN
cord-318495-1w74wf02	72	7	(	(	-LRB-
cord-318495-1w74wf02	72	8	200	200	CD
cord-318495-1w74wf02	72	9	-	-	SYM
cord-318495-1w74wf02	72	10	400	400	CD
cord-318495-1w74wf02	72	11	nt	nt	RB
cord-318495-1w74wf02	72	12	long	long	RB
cord-318495-1w74wf02	72	13	)	)	-RRB-
cord-318495-1w74wf02	72	14	that	that	DT
cord-318495-1w74wf02	72	15	is	be	VBZ
cord-318495-1w74wf02	72	16	highly	highly	RB
cord-318495-1w74wf02	72	17	complementary	complementary	JJ
cord-318495-1w74wf02	72	18	and	and	CC
cord-318495-1w74wf02	72	19	structured	structured	JJ
cord-318495-1w74wf02	72	20	,	,	,
cord-318495-1w74wf02	72	21	and	and	CC
cord-318495-1w74wf02	72	22	are	be	VBP
cord-318495-1w74wf02	72	23	adapted	adapt	VBN
cord-318495-1w74wf02	72	24	to	to	TO
cord-318495-1w74wf02	72	25	carry	carry	VB
cord-318495-1w74wf02	72	26	out	out	RP
cord-318495-1w74wf02	72	27	their	-PRON-	PRP$
cord-318495-1w74wf02	72	28	complete	complete	JJ
cord-318495-1w74wf02	72	29	life	life	NN
cord-318495-1w74wf02	72	30	cycle	cycle	NN
cord-318495-1w74wf02	72	31	as	as	IN
cord-318495-1w74wf02	72	32	a	a	DT
cord-318495-1w74wf02	72	33	result	result	NN
cord-318495-1w74wf02	72	34	from	from	IN
cord-318495-1w74wf02	72	35	interactions	interaction	NNS
cord-318495-1w74wf02	72	36	with	with	IN
cord-318495-1w74wf02	72	37	the	the	DT
cord-318495-1w74wf02	72	38	host	host	NN
cord-318495-1w74wf02	72	39	cell	cell	NN
cord-318495-1w74wf02	72	40	machinery	machinery	NN
cord-318495-1w74wf02	72	41	196	196	CD
cord-318495-1w74wf02	72	42	,	,	,
cord-318495-1w74wf02	72	43	197	197	CD
cord-318495-1w74wf02	72	44	.	.	.
cord-318495-1w74wf02	73	1	Virophages	virophage	NNS
cord-318495-1w74wf02	73	2	are	be	VBP
cord-318495-1w74wf02	73	3	15	15	CD
cord-318495-1w74wf02	73	4	-	-	SYM
cord-318495-1w74wf02	73	5	30	30	CD
cord-318495-1w74wf02	73	6	kbp	kbp	NN
cord-318495-1w74wf02	73	7	long	long	RB
cord-318495-1w74wf02	73	8	dsDNA	dsdna	RB
cord-318495-1w74wf02	73	9	viruses	virus	NNS
cord-318495-1w74wf02	73	10	that	that	WDT
cord-318495-1w74wf02	73	11	normally	normally	RB
cord-318495-1w74wf02	73	12	produce	produce	VBP
cord-318495-1w74wf02	73	13	icosahedral	icosahedral	JJ
cord-318495-1w74wf02	73	14	particles	particle	NNS
cord-318495-1w74wf02	73	15	and	and	CC
cord-318495-1w74wf02	73	16	parasitize	parasitize	VB
cord-318495-1w74wf02	73	17	from	from	IN
cord-318495-1w74wf02	73	18	giant	giant	JJ
cord-318495-1w74wf02	73	19	dsDNA	dsdna	JJ
cord-318495-1w74wf02	73	20	viruses	virus	NNS
cord-318495-1w74wf02	73	21	(	(	-LRB-
cord-318495-1w74wf02	73	22	mimiviruses	mimiviruse	NNS
cord-318495-1w74wf02	73	23	and	and	CC
cord-318495-1w74wf02	73	24	others	other	NNS
cord-318495-1w74wf02	73	25	)	)	-RRB-
cord-318495-1w74wf02	73	26	for	for	IN
cord-318495-1w74wf02	73	27	propagation	propagation	NN
cord-318495-1w74wf02	73	28	.	.	.
cord-318495-1w74wf02	74	1	Virophages	virophage	NNS
cord-318495-1w74wf02	74	2	infect	infect	VBP
cord-318495-1w74wf02	74	3	the	the	DT
cord-318495-1w74wf02	74	4	giant	giant	JJ
cord-318495-1w74wf02	74	5	virus	virus	NN
cord-318495-1w74wf02	74	6	factory	factory	NN
cord-318495-1w74wf02	74	7	,	,	,
cord-318495-1w74wf02	74	8	thereby	thereby	RB
cord-318495-1w74wf02	74	9	harming	harm	VBG
cord-318495-1w74wf02	74	10	the	the	DT
cord-318495-1w74wf02	74	11	giant	giant	JJ
cord-318495-1w74wf02	74	12	virus	virus	NN
cord-318495-1w74wf02	74	13	198	198	CD
cord-318495-1w74wf02	74	14	.	.	.
cord-318495-1w74wf02	75	1	The	the	DT
cord-318495-1w74wf02	75	2	first	first	JJ
cord-318495-1w74wf02	75	3	virophage	virophage	NN
cord-318495-1w74wf02	75	4	discovered	discover	VBD
cord-318495-1w74wf02	75	5	,	,	,
cord-318495-1w74wf02	75	6	Sputnik	Sputnik	NNP
cord-318495-1w74wf02	75	7	,	,	,
cord-318495-1w74wf02	75	8	was	be	VBD
cord-318495-1w74wf02	75	9	found	find	VBN
cord-318495-1w74wf02	75	10	together	together	RB
cord-318495-1w74wf02	75	11	with	with	IN
cord-318495-1w74wf02	75	12	Acanthamoeba	Acanthamoeba	NNP
cord-318495-1w74wf02	75	13	castellanii	castellanii	NNP
cord-318495-1w74wf02	75	14	mamavirus	mamavirus	NNP
cord-318495-1w74wf02	75	15	and	and	CC
cord-318495-1w74wf02	75	16	interferes	interfere	VBZ
cord-318495-1w74wf02	75	17	with	with	IN
cord-318495-1w74wf02	75	18	its	-PRON-	PRP$
cord-318495-1w74wf02	75	19	propagation	propagation	NN
cord-318495-1w74wf02	75	20	199	199	CD
cord-318495-1w74wf02	75	21	.	.	.
cord-318495-1w74wf02	76	1	Several	several	JJ
cord-318495-1w74wf02	76	2	other	other	JJ
cord-318495-1w74wf02	76	3	virophages	virophage	NNS
cord-318495-1w74wf02	76	4	,	,	,
cord-318495-1w74wf02	76	5	as	as	RB
cord-318495-1w74wf02	76	6	well	well	RB
cord-318495-1w74wf02	76	7	as	as	IN
cord-318495-1w74wf02	76	8	a	a	DT
cord-318495-1w74wf02	76	9	large	large	JJ
cord-318495-1w74wf02	76	10	number	number	NN
cord-318495-1w74wf02	76	11	of	of	IN
cord-318495-1w74wf02	76	12	virophage	virophage	NN
cord-318495-1w74wf02	76	13	candidates	candidate	NNS
cord-318495-1w74wf02	76	14	,	,	,
cord-318495-1w74wf02	76	15	have	have	VBP
cord-318495-1w74wf02	76	16	been	be	VBN
cord-318495-1w74wf02	76	17	identified	identify	VBN
cord-318495-1w74wf02	76	18	since	since	IN
cord-318495-1w74wf02	76	19	then	then	RB
cord-318495-1w74wf02	76	20	195	195	CD
cord-318495-1w74wf02	76	21	,	,	,
cord-318495-1w74wf02	76	22	198	198	CD
cord-318495-1w74wf02	76	23	,	,	,
cord-318495-1w74wf02	76	24	200	200	CD
cord-318495-1w74wf02	76	25	.	.	.
cord-318495-1w74wf02	77	1	Recent	recent	JJ
cord-318495-1w74wf02	77	2	studies	study	NNS
cord-318495-1w74wf02	77	3	show	show	VBP
cord-318495-1w74wf02	77	4	that	that	IN
cord-318495-1w74wf02	77	5	virophages	virophages	NNP
cord-318495-1w74wf02	77	6	could	could	MD
cord-318495-1w74wf02	77	7	resemble	resemble	VB
cord-318495-1w74wf02	77	8	bona	bona	JJ
cord-318495-1w74wf02	77	9	fide	fide	JJ
cord-318495-1w74wf02	77	10	DNA	dna	NN
cord-318495-1w74wf02	77	11	viruses	virus	NNS
cord-318495-1w74wf02	77	12	201	201	CD
cord-318495-1w74wf02	77	13	and	and	CC
cord-318495-1w74wf02	77	14	their	-PRON-	PRP$
cord-318495-1w74wf02	77	15	reclassification	reclassification	NN
cord-318495-1w74wf02	77	16	as	as	IN
cord-318495-1w74wf02	77	17	their	-PRON-	PRP$
cord-318495-1w74wf02	77	18	own	own	JJ
cord-318495-1w74wf02	77	19	viral	viral	JJ
cord-318495-1w74wf02	77	20	family	family	NN
cord-318495-1w74wf02	77	21	has	have	VBZ
cord-318495-1w74wf02	77	22	been	be	VBN
cord-318495-1w74wf02	77	23	proposed	propose	VBN
cord-318495-1w74wf02	77	24	195	195	CD
cord-318495-1w74wf02	77	25	.	.	.
cord-318495-1w74wf02	78	1	VLVs	VLVs	NNP
cord-318495-1w74wf02	78	2	are	be	VBP
cord-318495-1w74wf02	78	3	produced	produce	VBN
cord-318495-1w74wf02	78	4	during	during	IN
cord-318495-1w74wf02	78	5	viral	viral	JJ
cord-318495-1w74wf02	78	6	infection	infection	NN
cord-318495-1w74wf02	78	7	and	and	CC
cord-318495-1w74wf02	78	8	,	,	,
cord-318495-1w74wf02	78	9	in	in	IN
cord-318495-1w74wf02	78	10	contrast	contrast	NN
cord-318495-1w74wf02	78	11	to	to	IN
cord-318495-1w74wf02	78	12	other	other	JJ
cord-318495-1w74wf02	78	13	extracellular	extracellular	JJ
cord-318495-1w74wf02	78	14	vesicles	vesicle	NNS
cord-318495-1w74wf02	78	15	,	,	,
cord-318495-1w74wf02	78	16	contain	contain	VBP
cord-318495-1w74wf02	78	17	viral	viral	JJ
cord-318495-1w74wf02	78	18	proteins	protein	NNS
cord-318495-1w74wf02	78	19	and	and	CC
cord-318495-1w74wf02	78	20	nucleic	nucleic	JJ
cord-318495-1w74wf02	78	21	acids	acid	NNS
cord-318495-1w74wf02	78	22	but	but	CC
cord-318495-1w74wf02	78	23	lack	lack	NN
cord-318495-1w74wf02	78	24	capsid	capsid	NN
cord-318495-1w74wf02	78	25	protein	protein	NN
cord-318495-1w74wf02	78	26	or	or	CC
cord-318495-1w74wf02	78	27	viral	viral	JJ
cord-318495-1w74wf02	78	28	genomes	genome	NNS
cord-318495-1w74wf02	78	29	and	and	CC
cord-318495-1w74wf02	78	30	,	,	,
cord-318495-1w74wf02	78	31	therefore	therefore	RB
cord-318495-1w74wf02	78	32	,	,	,
cord-318495-1w74wf02	78	33	are	be	VBP
cord-318495-1w74wf02	78	34	not	not	RB
cord-318495-1w74wf02	78	35	infectious	infectious	JJ
cord-318495-1w74wf02	78	36	.	.	.
cord-318495-1w74wf02	79	1	VLVs	VLVs	NNP
cord-318495-1w74wf02	79	2	have	have	VBP
cord-318495-1w74wf02	79	3	been	be	VBN
cord-318495-1w74wf02	79	4	described	describe	VBN
cord-318495-1w74wf02	79	5	in	in	IN
cord-318495-1w74wf02	79	6	both	both	DT
cord-318495-1w74wf02	79	7	RNA	RNA	NNP
cord-318495-1w74wf02	79	8	and	and	CC
cord-318495-1w74wf02	79	9	DNA	dna	NN
cord-318495-1w74wf02	79	10	viruses	virus	NNS
cord-318495-1w74wf02	79	11	,	,	,
cord-318495-1w74wf02	79	12	including	include	VBG
cord-318495-1w74wf02	79	13	herpes	herpes	NN
cord-318495-1w74wf02	79	14	simplex	simplex	NN
cord-318495-1w74wf02	79	15	virus-1	virus-1	NN
cord-318495-1w74wf02	79	16	,	,	,
cord-318495-1w74wf02	79	17	hepatitis	hepatitis	NN
cord-318495-1w74wf02	79	18	C	c	NN
cord-318495-1w74wf02	79	19	virus	virus	NN
cord-318495-1w74wf02	79	20	and	and	CC
cord-318495-1w74wf02	79	21	Kaposi	Kaposi	NNP
cord-318495-1w74wf02	79	22	's	's	POS
cord-318495-1w74wf02	79	23	sarcoma	sarcoma	NN
cord-318495-1w74wf02	79	24	-	-	HYPH
cord-318495-1w74wf02	79	25	associated	associate	VBN
cord-318495-1w74wf02	79	26	herpes	herpes	NN
cord-318495-1w74wf02	79	27	virus	virus	NN
cord-318495-1w74wf02	79	28	.	.	.
cord-318495-1w74wf02	80	1	VLVs	VLVs	NNP
cord-318495-1w74wf02	80	2	play	play	VBP
cord-318495-1w74wf02	80	3	functional	functional	JJ
cord-318495-1w74wf02	80	4	roles	role	NNS
cord-318495-1w74wf02	80	5	during	during	IN
cord-318495-1w74wf02	80	6	viral	viral	JJ
cord-318495-1w74wf02	80	7	infections	infection	NNS
cord-318495-1w74wf02	80	8	by	by	IN
cord-318495-1w74wf02	80	9	facilitating	facilitate	VBG
cord-318495-1w74wf02	80	10	communication	communication	NN
cord-318495-1w74wf02	80	11	among	among	IN
cord-318495-1w74wf02	80	12	cells	cell	NNS
cord-318495-1w74wf02	80	13	and	and	CC
cord-318495-1w74wf02	80	14	enhancing	enhance	VBG
cord-318495-1w74wf02	80	15	viral	viral	JJ
cord-318495-1w74wf02	80	16	infection	infection	NN
cord-318495-1w74wf02	80	17	[	[	-LRB-
cord-318495-1w74wf02	80	18	202	202	CD
cord-318495-1w74wf02	80	19	]	]	-RRB-
cord-318495-1w74wf02	80	20	[	[	-LRB-
cord-318495-1w74wf02	80	21	203	203	CD
cord-318495-1w74wf02	80	22	]	]	-RRB-
cord-318495-1w74wf02	81	1	[	[	-LRB-
cord-318495-1w74wf02	81	2	204	204	CD
cord-318495-1w74wf02	81	3	]	]	-RRB-
cord-318495-1w74wf02	81	4	.	.	.
cord-318495-1w74wf02	82	1	Continued	continue	VBN
cord-318495-1w74wf02	82	2	virus	virus	NN
cord-318495-1w74wf02	82	3	,	,	,
cord-318495-1w74wf02	82	4	and	and	CC
cord-318495-1w74wf02	82	5	how	how	WRB
cord-318495-1w74wf02	82	6	best	good	JJS
cord-318495-1w74wf02	82	7	to	to	TO
cord-318495-1w74wf02	82	8	normalize	normalize	VB
cord-318495-1w74wf02	82	9	between	between	IN
cord-318495-1w74wf02	82	10	samples	sample	NNS
cord-318495-1w74wf02	82	11	and	and	CC
cord-318495-1w74wf02	82	12	between	between	IN
cord-318495-1w74wf02	82	13	sequencing	sequencing	NN
cord-318495-1w74wf02	82	14	runs	run	NNS
cord-318495-1w74wf02	82	15	-	-	:
cord-318495-1w74wf02	82	16	problems	problem	NNS
cord-318495-1w74wf02	82	17	that	that	WDT
cord-318495-1w74wf02	82	18	are	be	VBP
cord-318495-1w74wf02	82	19	similar	similar	JJ
cord-318495-1w74wf02	82	20	to	to	IN
cord-318495-1w74wf02	82	21	transcriptome	transcriptome	NN
cord-318495-1w74wf02	82	22	analysis	analysis	NN
cord-318495-1w74wf02	82	23	of	of	IN
cord-318495-1w74wf02	82	24	genetic	genetic	JJ
cord-318495-1w74wf02	82	25	isoforms	isoform	NNS
cord-318495-1w74wf02	82	26	.	.	.
cord-318495-1w74wf02	83	1	Furthermore	furthermore	RB
cord-318495-1w74wf02	83	2	,	,	,
cord-318495-1w74wf02	83	3	with	with	IN
cord-318495-1w74wf02	83	4	increasing	increase	VBG
cord-318495-1w74wf02	83	5	data	datum	NNS
cord-318495-1w74wf02	83	6	sets	set	NNS
cord-318495-1w74wf02	83	7	and	and	CC
cord-318495-1w74wf02	83	8	samples	sample	NNS
cord-318495-1w74wf02	83	9	,	,	,
cord-318495-1w74wf02	83	10	it	-PRON-	PRP
cord-318495-1w74wf02	83	11	is	be	VBZ
cord-318495-1w74wf02	83	12	becoming	become	VBG
cord-318495-1w74wf02	83	13	evident	evident	JJ
cord-318495-1w74wf02	83	14	that	that	IN
cord-318495-1w74wf02	83	15	DVG	DVG	NNP
cord-318495-1w74wf02	83	16	species	specie	NNS
cord-318495-1w74wf02	83	17	are	be	VBP
cord-318495-1w74wf02	83	18	not	not	RB
cord-318495-1w74wf02	83	19	necessarily	necessarily	RB
cord-318495-1w74wf02	83	20	the	the	DT
cord-318495-1w74wf02	83	21	same	same	JJ
cord-318495-1w74wf02	83	22	if	if	IN
cord-318495-1w74wf02	83	23	generated	generate	VBN
cord-318495-1w74wf02	83	24	in	in	IN
cord-318495-1w74wf02	83	25	different	different	JJ
cord-318495-1w74wf02	83	26	host	host	NN
cord-318495-1w74wf02	83	27	and	and	CC
cord-318495-1w74wf02	83	28	cell	cell	NN
cord-318495-1w74wf02	83	29	types	type	NNS
cord-318495-1w74wf02	83	30	,	,	,
cord-318495-1w74wf02	83	31	and	and	CC
cord-318495-1w74wf02	83	32	the	the	DT
cord-318495-1w74wf02	83	33	factors	factor	NNS
cord-318495-1w74wf02	83	34	dictating	dictate	VBG
cord-318495-1w74wf02	83	35	these	these	DT
cord-318495-1w74wf02	83	36	differences	difference	NNS
cord-318495-1w74wf02	83	37	remain	remain	VBP
cord-318495-1w74wf02	83	38	to	to	TO
cord-318495-1w74wf02	83	39	be	be	VB
cord-318495-1w74wf02	83	40	uncovered	uncover	VBN
cord-318495-1w74wf02	83	41	.	.	.
cord-318495-1w74wf02	84	1	DVGs	dvg	NNS
cord-318495-1w74wf02	84	2	have	have	VBP
cord-318495-1w74wf02	84	3	been	be	VBN
cord-318495-1w74wf02	84	4	long	long	RB
cord-318495-1w74wf02	84	5	considered	consider	VBN
cord-318495-1w74wf02	84	6	the	the	DT
cord-318495-1w74wf02	84	7	result	result	NN
cord-318495-1w74wf02	84	8	of	of	IN
cord-318495-1w74wf02	84	9	stochastic	stochastic	JJ
cord-318495-1w74wf02	84	10	mistakes	mistake	NNS
cord-318495-1w74wf02	84	11	introduced	introduce	VBN
cord-318495-1w74wf02	84	12	by	by	IN
cord-318495-1w74wf02	84	13	the	the	DT
cord-318495-1w74wf02	84	14	viral	viral	JJ
cord-318495-1w74wf02	84	15	RNA	RNA	NNP
cord-318495-1w74wf02	84	16	polymerase	polymerase	NN
cord-318495-1w74wf02	84	17	that	that	WDT
cord-318495-1w74wf02	84	18	lacks	lack	VBZ
cord-318495-1w74wf02	84	19	proofreading	proofread	VBG
cord-318495-1w74wf02	84	20	activity	activity	NN
cord-318495-1w74wf02	84	21	.	.	.
cord-318495-1w74wf02	85	1	However	however	RB
cord-318495-1w74wf02	85	2	,	,	,
cord-318495-1w74wf02	85	3	new	new	JJ
cord-318495-1w74wf02	85	4	evidence	evidence	NN
cord-318495-1w74wf02	85	5	suggests	suggest	VBZ
cord-318495-1w74wf02	85	6	that	that	IN
cord-318495-1w74wf02	85	7	additional	additional	JJ
cord-318495-1w74wf02	85	8	factors	factor	NNS
cord-318495-1w74wf02	85	9	control	control	VBP
cord-318495-1w74wf02	85	10	DVG	DVG	NNP
cord-318495-1w74wf02	85	11	generation	generation	NN
cord-318495-1w74wf02	85	12	,	,	,
cord-318495-1w74wf02	85	13	opening	open	VBG
cord-318495-1w74wf02	85	14	the	the	DT
cord-318495-1w74wf02	85	15	possibility	possibility	NN
cord-318495-1w74wf02	85	16	of	of	IN
cord-318495-1w74wf02	85	17	manipulating	manipulate	VBG
cord-318495-1w74wf02	85	18	their	-PRON-	PRP$
cord-318495-1w74wf02	85	19	generation	generation	NN
cord-318495-1w74wf02	85	20	for	for	IN
cord-318495-1w74wf02	85	21	therapeutic	therapeutic	JJ
cord-318495-1w74wf02	85	22	purposes	purpose	NNS
cord-318495-1w74wf02	85	23	.	.	.
cord-318495-1w74wf02	86	1	Random	random	JJ
cord-318495-1w74wf02	86	2	products	product	NNS
cord-318495-1w74wf02	86	3	or	or	CC
cord-318495-1w74wf02	86	4	encoded	encode	VBN
cord-318495-1w74wf02	86	5	in	in	IN
cord-318495-1w74wf02	86	6	the	the	DT
cord-318495-1w74wf02	86	7	viral	viral	JJ
cord-318495-1w74wf02	86	8	genome	genome	NN
cord-318495-1w74wf02	86	9	?	?	.
cord-318495-1w74wf02	87	1	While	while	IN
cord-318495-1w74wf02	87	2	DVGs	dvg	NNS
cord-318495-1w74wf02	87	3	are	be	VBP
cord-318495-1w74wf02	87	4	generated	generate	VBN
cord-318495-1w74wf02	87	5	by	by	IN
cord-318495-1w74wf02	87	6	many	many	JJ
cord-318495-1w74wf02	87	7	viruses	virus	NNS
cord-318495-1w74wf02	87	8	,	,	,
cord-318495-1w74wf02	87	9	the	the	DT
cord-318495-1w74wf02	87	10	molecular	molecular	JJ
cord-318495-1w74wf02	87	11	mechanisms	mechanism	NNS
cord-318495-1w74wf02	87	12	that	that	WDT
cord-318495-1w74wf02	87	13	govern	govern	VBP
cord-318495-1w74wf02	87	14	their	-PRON-	PRP$
cord-318495-1w74wf02	87	15	generation	generation	NN
cord-318495-1w74wf02	87	16	are	be	VBP
cord-318495-1w74wf02	87	17	poorly	poorly	RB
cord-318495-1w74wf02	87	18	understood	understand	VBN
cord-318495-1w74wf02	87	19	.	.	.
cord-318495-1w74wf02	88	1	A	a	DT
cord-318495-1w74wf02	88	2	predominant	predominant	JJ
cord-318495-1w74wf02	88	3	theory	theory	NN
cord-318495-1w74wf02	88	4	is	be	VBZ
cord-318495-1w74wf02	88	5	that	that	IN
cord-318495-1w74wf02	88	6	DVGs	dvg	NNS
cord-318495-1w74wf02	88	7	arise	arise	VB
cord-318495-1w74wf02	88	8	from	from	IN
cord-318495-1w74wf02	88	9	random	random	JJ
cord-318495-1w74wf02	88	10	errors	error	NNS
cord-318495-1w74wf02	88	11	that	that	WDT
cord-318495-1w74wf02	88	12	occur	occur	VBP
cord-318495-1w74wf02	88	13	during	during	IN
cord-318495-1w74wf02	88	14	viral	viral	JJ
cord-318495-1w74wf02	88	15	replication	replication	NN
cord-318495-1w74wf02	88	16	at	at	IN
cord-318495-1w74wf02	88	17	high	high	JJ
cord-318495-1w74wf02	88	18	viral	viral	JJ
cord-318495-1w74wf02	88	19	titers	titer	NNS
cord-318495-1w74wf02	88	20	due	due	JJ
cord-318495-1w74wf02	88	21	to	to	IN
cord-318495-1w74wf02	88	22	the	the	DT
cord-318495-1w74wf02	88	23	combination	combination	NN
cord-318495-1w74wf02	88	24	of	of	IN
cord-318495-1w74wf02	88	25	a	a	DT
cord-318495-1w74wf02	88	26	lack	lack	NN
cord-318495-1w74wf02	88	27	of	of	IN
cord-318495-1w74wf02	88	28	proofreading	proofread	VBG
cord-318495-1w74wf02	88	29	activity	activity	NN
cord-318495-1w74wf02	88	30	of	of	IN
cord-318495-1w74wf02	88	31	the	the	DT
cord-318495-1w74wf02	88	32	viral	viral	JJ
cord-318495-1w74wf02	88	33	polymerase	polymerase	NN
cord-318495-1w74wf02	88	34	and	and	CC
cord-318495-1w74wf02	88	35	the	the	DT
cord-318495-1w74wf02	88	36	presence	presence	NN
cord-318495-1w74wf02	88	37	of	of	IN
cord-318495-1w74wf02	88	38	lower	low	JJR
cord-318495-1w74wf02	88	39	fidelity	fidelity	NN
cord-318495-1w74wf02	88	40	variants	variant	NNS
cord-318495-1w74wf02	88	41	that	that	WDT
cord-318495-1w74wf02	88	42	favour	favour	VBP
cord-318495-1w74wf02	88	43	the	the	DT
cord-318495-1w74wf02	88	44	generation	generation	NN
cord-318495-1w74wf02	88	45	of	of	IN
cord-318495-1w74wf02	88	46	deletions	deletion	NNS
cord-318495-1w74wf02	88	47	.	.	.
cord-318495-1w74wf02	89	1	In	in	IN
cord-318495-1w74wf02	89	2	support	support	NN
cord-318495-1w74wf02	89	3	,	,	,
cord-318495-1w74wf02	89	4	analyses	analysis	NNS
cord-318495-1w74wf02	89	5	using	use	VBG
cord-318495-1w74wf02	89	6	deep	deep	JJ
cord-318495-1w74wf02	89	7	sequencing	sequencing	NN
cord-318495-1w74wf02	89	8	approaches	approach	NNS
cord-318495-1w74wf02	89	9	revealed	reveal	VBD
cord-318495-1w74wf02	89	10	that	that	IN
cord-318495-1w74wf02	89	11	multiple	multiple	JJ
cord-318495-1w74wf02	89	12	species	specie	NNS
cord-318495-1w74wf02	89	13	of	of	IN
cord-318495-1w74wf02	89	14	DVGs	dvg	NNS
cord-318495-1w74wf02	89	15	are	be	VBP
cord-318495-1w74wf02	89	16	generated	generate	VBN
cord-318495-1w74wf02	89	17	during	during	IN
cord-318495-1w74wf02	89	18	infection	infection	NN
cord-318495-1w74wf02	89	19	.	.	.
cord-318495-1w74wf02	90	1	For	for	IN
cord-318495-1w74wf02	90	2	example	example	NN
cord-318495-1w74wf02	90	3	,	,	,
cord-318495-1w74wf02	90	4	in	in	IN
cord-318495-1w74wf02	90	5	infections	infection	NNS
cord-318495-1w74wf02	90	6	with	with	IN
cord-318495-1w74wf02	90	7	Flock	Flock	NNP
cord-318495-1w74wf02	90	8	house	house	NN
cord-318495-1w74wf02	90	9	virus	virus	NN
cord-318495-1w74wf02	90	10	,	,	,
cord-318495-1w74wf02	90	11	a	a	DT
cord-318495-1w74wf02	90	12	positive	positive	JJ
cord-318495-1w74wf02	90	13	-	-	HYPH
cord-318495-1w74wf02	90	14	sense	sense	NN
cord-318495-1w74wf02	90	15	(	(	-LRB-
cord-318495-1w74wf02	90	16	ps)RNA	ps)rna	NN
cord-318495-1w74wf02	90	17	virus	virus	NN
cord-318495-1w74wf02	90	18	,	,	,
cord-318495-1w74wf02	90	19	ClickSeq	ClickSeq	NNP
cord-318495-1w74wf02	90	20	and	and	CC
cord-318495-1w74wf02	90	21	nanopore	nanopore	NNP
cord-318495-1w74wf02	90	22	sequencing	sequencing	NN
cord-318495-1w74wf02	90	23	identified	identify	VBD
cord-318495-1w74wf02	90	24	a	a	DT
cord-318495-1w74wf02	90	25	large	large	JJ
cord-318495-1w74wf02	90	26	and	and	CC
cord-318495-1w74wf02	90	27	seemingly	seemingly	RB
cord-318495-1w74wf02	90	28	random	random	JJ
cord-318495-1w74wf02	90	29	population	population	NN
cord-318495-1w74wf02	90	30	of	of	IN
cord-318495-1w74wf02	90	31	deletion	deletion	NN
cord-318495-1w74wf02	90	32	DVGs	dvg	NNS
cord-318495-1w74wf02	90	33	early	early	RB
cord-318495-1w74wf02	90	34	after	after	IN
cord-318495-1w74wf02	90	35	infection	infection	NN
cord-318495-1w74wf02	90	36	48	48	CD
cord-318495-1w74wf02	90	37	.	.	.
cord-318495-1w74wf02	91	1	In	in	IN
cord-318495-1w74wf02	91	2	addition	addition	NN
cord-318495-1w74wf02	91	3	,	,	,
cord-318495-1w74wf02	91	4	sequencing	sequence	VBG
cord-318495-1w74wf02	91	5	analysis	analysis	NN
cord-318495-1w74wf02	91	6	of	of	IN
cord-318495-1w74wf02	91	7	nasopharyngeal	nasopharyngeal	JJ
cord-318495-1w74wf02	91	8	samples	sample	NNS
cord-318495-1w74wf02	91	9	from	from	IN
cord-318495-1w74wf02	91	10	influenza	influenza	NN
cord-318495-1w74wf02	91	11	virus	virus	NN
cord-318495-1w74wf02	91	12	-	-	HYPH
cord-318495-1w74wf02	91	13	infected	infect	VBN
cord-318495-1w74wf02	91	14	humans	human	NNS
cord-318495-1w74wf02	91	15	or	or	CC
cord-318495-1w74wf02	91	16	infections	infection	NNS
cord-318495-1w74wf02	91	17	in	in	IN
cord-318495-1w74wf02	91	18	vitro	vitro	FW
cord-318495-1w74wf02	91	19	with	with	IN
cord-318495-1w74wf02	91	20	human	human	JJ
cord-318495-1w74wf02	91	21	metapneumovirus	metapneumovirus	NNP
cord-318495-1w74wf02	91	22	or	or	CC
cord-318495-1w74wf02	91	23	measles	measles	NNP
cord-318495-1w74wf02	91	24	virus	virus	NN
cord-318495-1w74wf02	91	25	(	(	-LRB-
cord-318495-1w74wf02	91	26	MeV	MeV	NNP
cord-318495-1w74wf02	91	27	)	)	-RRB-
cord-318495-1w74wf02	91	28	revealed	reveal	VBD
cord-318495-1w74wf02	91	29	multiple	multiple	JJ
cord-318495-1w74wf02	91	30	DVG	DVG	NNP
cord-318495-1w74wf02	91	31	species	specie	NNS
cord-318495-1w74wf02	91	32	in	in	IN
cord-318495-1w74wf02	91	33	these	these	DT
cord-318495-1w74wf02	91	34	infections	infection	NNS
cord-318495-1w74wf02	91	35	[	[	-LRB-
cord-318495-1w74wf02	91	36	51	51	CD
cord-318495-1w74wf02	91	37	]	]	-RRB-
cord-318495-1w74wf02	91	38	[	[	-LRB-
cord-318495-1w74wf02	91	39	52	52	CD
cord-318495-1w74wf02	91	40	]	]	-RRB-
cord-318495-1w74wf02	91	41	[	[	-LRB-
cord-318495-1w74wf02	91	42	53	53	CD
cord-318495-1w74wf02	91	43	]	]	-RRB-
cord-318495-1w74wf02	91	44	.	.	.
cord-318495-1w74wf02	92	1	However	however	RB
cord-318495-1w74wf02	92	2	,	,	,
cord-318495-1w74wf02	92	3	different	different	JJ
cord-318495-1w74wf02	92	4	from	from	IN
cord-318495-1w74wf02	92	5	deletion	deletion	NN
cord-318495-1w74wf02	92	6	and	and	CC
cord-318495-1w74wf02	92	7	point	point	NN
cord-318495-1w74wf02	92	8	mutation	mutation	NN
cord-318495-1w74wf02	92	9	DVGs	dvg	NNS
cord-318495-1w74wf02	92	10	,	,	,
cord-318495-1w74wf02	92	11	copy	copy	NN
cord-318495-1w74wf02	92	12	-	-	HYPH
cord-318495-1w74wf02	92	13	back	back	NN
cord-318495-1w74wf02	92	14	DVGs	dvg	NNS
cord-318495-1w74wf02	92	15	are	be	VBP
cord-318495-1w74wf02	92	16	frequently	frequently	RB
cord-318495-1w74wf02	92	17	found	find	VBN
cord-318495-1w74wf02	92	18	in	in	IN
cord-318495-1w74wf02	92	19	discrete	discrete	JJ
cord-318495-1w74wf02	92	20	dominant	dominant	JJ
cord-318495-1w74wf02	92	21	populations	population	NNS
cord-318495-1w74wf02	92	22	in	in	IN
cord-318495-1w74wf02	92	23	an	an	DT
cord-318495-1w74wf02	92	24	infected	infected	JJ
cord-318495-1w74wf02	92	25	cell	cell	NN
cord-318495-1w74wf02	92	26	or	or	CC
cord-318495-1w74wf02	92	27	tissue	tissue	NN
cord-318495-1w74wf02	92	28	,	,	,
cord-318495-1w74wf02	92	29	and	and	CC
cord-318495-1w74wf02	93	1	the	the	DT
cord-318495-1w74wf02	93	2	same	same	JJ
cord-318495-1w74wf02	93	3	copy	copy	NN
cord-318495-1w74wf02	93	4	-	-	HYPH
cord-318495-1w74wf02	93	5	back	back	NN
cord-318495-1w74wf02	94	1	DVG	DVG	NNP
cord-318495-1w74wf02	94	2	seems	seem	VBZ
cord-318495-1w74wf02	94	3	to	to	TO
cord-318495-1w74wf02	94	4	arise	arise	VB
cord-318495-1w74wf02	94	5	in	in	IN
cord-318495-1w74wf02	94	6	independent	independent	JJ
cord-318495-1w74wf02	94	7	infections	infection	NNS
cord-318495-1w74wf02	94	8	with	with	IN
cord-318495-1w74wf02	94	9	the	the	DT
cord-318495-1w74wf02	94	10	same	same	JJ
cord-318495-1w74wf02	94	11	parental	parental	JJ
cord-318495-1w74wf02	94	12	virus	virus	NN
cord-318495-1w74wf02	94	13	54	54	CD
cord-318495-1w74wf02	94	14	,	,	,
cord-318495-1w74wf02	94	15	55	55	CD
cord-318495-1w74wf02	94	16	or	or	CC
cord-318495-1w74wf02	94	17	during	during	IN
cord-318495-1w74wf02	94	18	infections	infection	NNS
cord-318495-1w74wf02	94	19	with	with	IN
cord-318495-1w74wf02	94	20	different	different	JJ
cord-318495-1w74wf02	94	21	virus	virus	NN
cord-318495-1w74wf02	94	22	strains	strain	VBZ
cord-318495-1w74wf02	94	23	56	56	CD
cord-318495-1w74wf02	94	24	.	.	.
cord-318495-1w74wf02	95	1	The	the	DT
cord-318495-1w74wf02	95	2	demonstration	demonstration	NN
cord-318495-1w74wf02	95	3	of	of	IN
cord-318495-1w74wf02	95	4	hotspots	hotspot	NNS
cord-318495-1w74wf02	95	5	for	for	IN
cord-318495-1w74wf02	95	6	the	the	DT
cord-318495-1w74wf02	95	7	generation	generation	NN
cord-318495-1w74wf02	95	8	of	of	IN
cord-318495-1w74wf02	95	9	copyback	copyback	NN
cord-318495-1w74wf02	95	10	DVGs	dvg	NNS
cord-318495-1w74wf02	95	11	from	from	IN
cord-318495-1w74wf02	95	12	respiratory	respiratory	JJ
cord-318495-1w74wf02	95	13	syncytial	syncytial	JJ
cord-318495-1w74wf02	95	14	virus	virus	NN
cord-318495-1w74wf02	95	15	(	(	-LRB-
cord-318495-1w74wf02	95	16	RSV	RSV	NNP
cord-318495-1w74wf02	95	17	)	)	-RRB-
cord-318495-1w74wf02	95	18	and	and	CC
cord-318495-1w74wf02	95	19	the	the	DT
cord-318495-1w74wf02	95	20	identification	identification	NN
cord-318495-1w74wf02	95	21	of	of	IN
cord-318495-1w74wf02	95	22	specific	specific	JJ
cord-318495-1w74wf02	95	23	nucleotides	nucleotide	NNS
cord-318495-1w74wf02	95	24	that	that	WDT
cord-318495-1w74wf02	95	25	determine	determine	VBP
cord-318495-1w74wf02	95	26	where	where	WRB
cord-318495-1w74wf02	95	27	copy	copy	NN
cord-318495-1w74wf02	95	28	-	-	HYPH
cord-318495-1w74wf02	95	29	back	back	NN
cord-318495-1w74wf02	95	30	DVGs	dvg	NNS
cord-318495-1w74wf02	95	31	rejoin	rejoin	VBP
cord-318495-1w74wf02	95	32	further	further	RB
cord-318495-1w74wf02	95	33	demonstrate	demonstrate	VB
cord-318495-1w74wf02	95	34	that	that	IN
cord-318495-1w74wf02	95	35	the	the	DT
cord-318495-1w74wf02	95	36	generation	generation	NN
cord-318495-1w74wf02	95	37	of	of	IN
cord-318495-1w74wf02	95	38	copy	copy	NN
cord-318495-1w74wf02	95	39	-	-	HYPH
cord-318495-1w74wf02	95	40	back	back	NN
cord-318495-1w74wf02	95	41	DVGs	dvg	NNS
cord-318495-1w74wf02	95	42	is	be	VBZ
cord-318495-1w74wf02	95	43	not	not	RB
cord-318495-1w74wf02	95	44	completely	completely	RB
cord-318495-1w74wf02	95	45	random	random	JJ
cord-318495-1w74wf02	95	46	,	,	,
cord-318495-1w74wf02	95	47	but	but	CC
cord-318495-1w74wf02	95	48	instead	instead	RB
cord-318495-1w74wf02	95	49	that	that	DT
cord-318495-1w74wf02	95	50	specific	specific	JJ
cord-318495-1w74wf02	95	51	sequences	sequence	NNS
cord-318495-1w74wf02	95	52	encoded	encode	VBN
cord-318495-1w74wf02	95	53	in	in	IN
cord-318495-1w74wf02	95	54	the	the	DT
cord-318495-1w74wf02	95	55	viral	viral	JJ
cord-318495-1w74wf02	95	56	genome	genome	NN
cord-318495-1w74wf02	95	57	direct	direct	JJ
cord-318495-1w74wf02	95	58	or	or	CC
cord-318495-1w74wf02	95	59	facilitate	facilitate	VBP
cord-318495-1w74wf02	95	60	their	-PRON-	PRP$
cord-318495-1w74wf02	95	61	formation	formation	NN
cord-318495-1w74wf02	95	62	50	50	CD
cord-318495-1w74wf02	95	63	in	in	IN
cord-318495-1w74wf02	95	64	some	some	DT
cord-318495-1w74wf02	95	65	infections	infection	NNS
cord-318495-1w74wf02	95	66	,	,	,
cord-318495-1w74wf02	95	67	DVG	DVG	NNP
cord-318495-1w74wf02	95	68	generation	generation	NN
cord-318495-1w74wf02	95	69	is	be	VBZ
cord-318495-1w74wf02	95	70	not	not	RB
cord-318495-1w74wf02	95	71	a	a	DT
cord-318495-1w74wf02	95	72	completely	completely	RB
cord-318495-1w74wf02	95	73	stochastic	stochastic	JJ
cord-318495-1w74wf02	95	74	process	process	NN
cord-318495-1w74wf02	95	75	and	and	CC
cord-318495-1w74wf02	95	76	,	,	,
cord-318495-1w74wf02	95	77	instead	instead	RB
cord-318495-1w74wf02	95	78	,	,	,
cord-318495-1w74wf02	95	79	virus	virus	NN
cord-318495-1w74wf02	95	80	-	-	HYPH
cord-318495-1w74wf02	95	81	encoded	encode	VBN
cord-318495-1w74wf02	95	82	sequences	sequence	NNS
cord-318495-1w74wf02	95	83	favour	favour	VBP
cord-318495-1w74wf02	95	84	the	the	DT
cord-318495-1w74wf02	95	85	production	production	NN
cord-318495-1w74wf02	95	86	and/or	and/or	CC
cord-318495-1w74wf02	95	87	amplification	amplification	NN
cord-318495-1w74wf02	95	88	of	of	IN
cord-318495-1w74wf02	95	89	predominant	predominant	JJ
cord-318495-1w74wf02	95	90	DVGs	dvg	NNS
cord-318495-1w74wf02	95	91	.	.	.
cord-318495-1w74wf02	96	1	It	-PRON-	PRP
cord-318495-1w74wf02	96	2	remains	remain	VBZ
cord-318495-1w74wf02	96	3	to	to	TO
cord-318495-1w74wf02	96	4	be	be	VB
cord-318495-1w74wf02	96	5	determined	determine	VBN
cord-318495-1w74wf02	96	6	whether	whether	IN
cord-318495-1w74wf02	96	7	conservation	conservation	NN
cord-318495-1w74wf02	96	8	is	be	VBZ
cord-318495-1w74wf02	96	9	a	a	DT
cord-318495-1w74wf02	96	10	property	property	NN
cord-318495-1w74wf02	96	11	of	of	IN
cord-318495-1w74wf02	96	12	certain	certain	JJ
cord-318495-1w74wf02	96	13	DVG	DVG	NNP
cord-318495-1w74wf02	96	14	types	type	NNS
cord-318495-1w74wf02	96	15	and	and	CC
cord-318495-1w74wf02	96	16	which	which	WDT
cord-318495-1w74wf02	96	17	specific	specific	JJ
cord-318495-1w74wf02	96	18	sequences	sequence	NNS
cord-318495-1w74wf02	97	1	and/or	and/or	CC
cord-318495-1w74wf02	98	1	RNA	RNA	NNP
cord-318495-1w74wf02	98	2	structures	structure	NNS
cord-318495-1w74wf02	98	3	lead	lead	VBP
cord-318495-1w74wf02	98	4	to	to	IN
cord-318495-1w74wf02	98	5	DVG	DVG	NNP
cord-318495-1w74wf02	98	6	generation	generation	NN
cord-318495-1w74wf02	98	7	in	in	IN
cord-318495-1w74wf02	98	8	these	these	DT
cord-318495-1w74wf02	98	9	conditions	condition	NNS
cord-318495-1w74wf02	98	10	.	.	.
cord-318495-1w74wf02	99	1	A	a	DT
cord-318495-1w74wf02	99	2	number	number	NN
cord-318495-1w74wf02	99	3	of	of	IN
cord-318495-1w74wf02	99	4	viral	viral	JJ
cord-318495-1w74wf02	99	5	proteins	protein	NNS
cord-318495-1w74wf02	99	6	are	be	VBP
cord-318495-1w74wf02	99	7	implicated	implicate	VBN
cord-318495-1w74wf02	99	8	in	in	IN
cord-318495-1w74wf02	99	9	the	the	DT
cord-318495-1w74wf02	99	10	generation	generation	NN
cord-318495-1w74wf02	99	11	of	of	IN
cord-318495-1w74wf02	99	12	DVGs	dvg	NNS
cord-318495-1w74wf02	99	13	,	,	,
cord-318495-1w74wf02	99	14	the	the	DT
cord-318495-1w74wf02	99	15	best	well	RBS
cord-318495-1w74wf02	99	16	studied	study	VBN
cord-318495-1w74wf02	99	17	being	be	VBG
cord-318495-1w74wf02	99	18	the	the	DT
cord-318495-1w74wf02	99	19	viral	viral	JJ
cord-318495-1w74wf02	99	20	RdRP	rdrp	NN
cord-318495-1w74wf02	99	21	.	.	.
cord-318495-1w74wf02	100	1	Engineered	engineer	VBN
cord-318495-1w74wf02	100	2	viral	viral	JJ
cord-318495-1w74wf02	100	3	polymerases	polymerase	NNS
cord-318495-1w74wf02	100	4	with	with	IN
cord-318495-1w74wf02	100	5	a	a	DT
cord-318495-1w74wf02	100	6	decreased	decreased	JJ
cord-318495-1w74wf02	100	7	fidelity	fidelity	NN
cord-318495-1w74wf02	100	8	and	and	CC
cord-318495-1w74wf02	100	9	an	an	DT
cord-318495-1w74wf02	100	10	increased	increase	VBN
cord-318495-1w74wf02	100	11	mutation	mutation	NN
cord-318495-1w74wf02	100	12	rate	rate	NN
cord-318495-1w74wf02	100	13	produce	produce	VBP
cord-318495-1w74wf02	100	14	highly	highly	RB
cord-318495-1w74wf02	100	15	attenuated	attenuate	VBN
cord-318495-1w74wf02	100	16	viruses	virus	NNS
cord-318495-1w74wf02	100	17	60	60	CD
cord-318495-1w74wf02	100	18	,	,	,
cord-318495-1w74wf02	100	19	61	61	CD
cord-318495-1w74wf02	100	20	which	which	WDT
cord-318495-1w74wf02	100	21	,	,	,
cord-318495-1w74wf02	100	22	in	in	IN
cord-318495-1w74wf02	100	23	many	many	JJ
cord-318495-1w74wf02	100	24	instances	instance	NNS
cord-318495-1w74wf02	100	25	,	,	,
cord-318495-1w74wf02	100	26	correlate	correlate	VBP
cord-318495-1w74wf02	100	27	with	with	IN
cord-318495-1w74wf02	100	28	enhanced	enhanced	JJ
cord-318495-1w74wf02	100	29	production	production	NN
cord-318495-1w74wf02	100	30	of	of	IN
cord-318495-1w74wf02	100	31	DVGs	dvg	NNS
cord-318495-1w74wf02	100	32	62	62	CD
cord-318495-1w74wf02	100	33	-	-	SYM
cord-318495-1w74wf02	100	34	65	65	CD
cord-318495-1w74wf02	101	1	(	(	-LRB-
cord-318495-1w74wf02	101	2	Fig	Fig	NNP
cord-318495-1w74wf02	101	3	.	.	.
cord-318495-1w74wf02	101	4	2a	2a	CD
cord-318495-1w74wf02	101	5	)	)	-RRB-
cord-318495-1w74wf02	101	6	.	.	.
cord-318495-1w74wf02	102	1	Although	although	IN
cord-318495-1w74wf02	102	2	the	the	DT
cord-318495-1w74wf02	102	3	mechanism	mechanism	NN
cord-318495-1w74wf02	102	4	mediating	mediate	VBG
cord-318495-1w74wf02	102	5	DVG	DVG	NNP
cord-318495-1w74wf02	102	6	generation	generation	NN
cord-318495-1w74wf02	102	7	by	by	IN
cord-318495-1w74wf02	102	8	mutant	mutant	JJ
cord-318495-1w74wf02	102	9	RdRP	RdRP	NNP
cord-318495-1w74wf02	102	10	remains	remain	VBZ
cord-318495-1w74wf02	102	11	speculative	speculative	JJ
cord-318495-1w74wf02	102	12	,	,	,
cord-318495-1w74wf02	102	13	a	a	DT
cord-318495-1w74wf02	102	14	few	few	JJ
cord-318495-1w74wf02	102	15	models	model	NNS
cord-318495-1w74wf02	102	16	are	be	VBP
cord-318495-1w74wf02	102	17	emerging	emerge	VBG
cord-318495-1w74wf02	102	18	.	.	.
cord-318495-1w74wf02	103	1	For	for	IN
cord-318495-1w74wf02	103	2	example	example	NN
cord-318495-1w74wf02	103	3	,	,	,
cord-318495-1w74wf02	103	4	in	in	IN
cord-318495-1w74wf02	103	5	viruses	virus	NNS
cord-318495-1w74wf02	103	6	with	with	IN
cord-318495-1w74wf02	103	7	low	low	JJ
cord-318495-1w74wf02	103	8	-	-	HYPH
cord-318495-1w74wf02	103	9	fidelity	fidelity	NN
cord-318495-1w74wf02	103	10	RdRP	rdrp	NN
cord-318495-1w74wf02	103	11	,	,	,
cord-318495-1w74wf02	103	12	such	such	JJ
cord-318495-1w74wf02	103	13	as	as	IN
cord-318495-1w74wf02	103	14	Sindbis	Sindbis	NNP
cord-318495-1w74wf02	103	15	virus	virus	NN
cord-318495-1w74wf02	103	16	or	or	CC
cord-318495-1w74wf02	103	17	tombusvirus	tombusvirus	NN
cord-318495-1w74wf02	103	18	,	,	,
cord-318495-1w74wf02	103	19	an	an	DT
cord-318495-1w74wf02	103	20	increased	increase	VBN
cord-318495-1w74wf02	103	21	production	production	NN
cord-318495-1w74wf02	103	22	of	of	IN
cord-318495-1w74wf02	103	23	DVGs	dvg	NNS
cord-318495-1w74wf02	103	24	correlates	correlate	VBZ
cord-318495-1w74wf02	103	25	with	with	IN
cord-318495-1w74wf02	103	26	an	an	DT
cord-318495-1w74wf02	103	27	enhanced	enhanced	JJ
cord-318495-1w74wf02	103	28	rate	rate	NN
cord-318495-1w74wf02	103	29	of	of	IN
cord-318495-1w74wf02	103	30	viral	viral	JJ
cord-318495-1w74wf02	103	31	RNA	RNA	NNP
cord-318495-1w74wf02	103	32	recombination	recombination	NN
cord-318495-1w74wf02	103	33	63	63	CD
cord-318495-1w74wf02	103	34	,	,	,
cord-318495-1w74wf02	103	35	65	65	CD
cord-318495-1w74wf02	103	36	.	.	.
cord-318495-1w74wf02	104	1	In	in	IN
cord-318495-1w74wf02	104	2	addition	addition	NN
cord-318495-1w74wf02	104	3	,	,	,
cord-318495-1w74wf02	104	4	during	during	IN
cord-318495-1w74wf02	104	5	influenza	influenza	NN
cord-318495-1w74wf02	104	6	virus	virus	NN
cord-318495-1w74wf02	104	7	infection	infection	NN
cord-318495-1w74wf02	104	8	,	,	,
cord-318495-1w74wf02	104	9	variations	variation	NNS
cord-318495-1w74wf02	104	10	in	in	IN
cord-318495-1w74wf02	104	11	the	the	DT
cord-318495-1w74wf02	104	12	elongation	elongation	NN
cord-318495-1w74wf02	104	13	capacity	capacity	NN
cord-318495-1w74wf02	104	14	of	of	IN
cord-318495-1w74wf02	104	15	the	the	DT
cord-318495-1w74wf02	104	16	polymerase	polymerase	NN
cord-318495-1w74wf02	104	17	associate	associate	NN
cord-318495-1w74wf02	104	18	with	with	IN
cord-318495-1w74wf02	104	19	differential	differential	JJ
cord-318495-1w74wf02	104	20	generation	generation	NN
cord-318495-1w74wf02	104	21	of	of	IN
cord-318495-1w74wf02	104	22	DVGs	dvg	NNS
cord-318495-1w74wf02	104	23	64	64	CD
cord-318495-1w74wf02	104	24	.	.	.
cord-318495-1w74wf02	105	1	A	a	DT
cord-318495-1w74wf02	105	2	role	role	NN
cord-318495-1w74wf02	105	3	for	for	IN
cord-318495-1w74wf02	105	4	the	the	DT
cord-318495-1w74wf02	105	5	polymerase	polymerase	NN
cord-318495-1w74wf02	105	6	multimerization	multimerization	NN
cord-318495-1w74wf02	105	7	activity	activity	NN
cord-318495-1w74wf02	105	8	was	be	VBD
cord-318495-1w74wf02	105	9	also	also	RB
cord-318495-1w74wf02	105	10	recently	recently	RB
cord-318495-1w74wf02	105	11	proposed	propose	VBN
cord-318495-1w74wf02	105	12	as	as	IN
cord-318495-1w74wf02	105	13	a	a	DT
cord-318495-1w74wf02	105	14	driver	driver	NN
cord-318495-1w74wf02	105	15	of	of	IN
cord-318495-1w74wf02	105	16	DVG	DVG	NNP
cord-318495-1w74wf02	105	17	generation	generation	NN
cord-318495-1w74wf02	105	18	during	during	IN
cord-318495-1w74wf02	105	19	influenza	influenza	NN
cord-318495-1w74wf02	105	20	virus	virus	NN
cord-318495-1w74wf02	105	21	infection	infection	NN
cord-318495-1w74wf02	105	22	62	62	CD
cord-318495-1w74wf02	105	23	.	.	.
cord-318495-1w74wf02	106	1	Viral	viral	JJ
cord-318495-1w74wf02	106	2	proteins	protein	NNS
cord-318495-1w74wf02	106	3	implicated	implicate	VBN
cord-318495-1w74wf02	106	4	in	in	IN
cord-318495-1w74wf02	106	5	the	the	DT
cord-318495-1w74wf02	106	6	regulation	regulation	NN
cord-318495-1w74wf02	106	7	of	of	IN
cord-318495-1w74wf02	106	8	viral	viral	JJ
cord-318495-1w74wf02	106	9	transcription	transcription	NN
cord-318495-1w74wf02	106	10	and	and	CC
cord-318495-1w74wf02	106	11	replication	replication	NN
cord-318495-1w74wf02	106	12	are	be	VBP
cord-318495-1w74wf02	106	13	also	also	RB
cord-318495-1w74wf02	106	14	associated	associate	VBN
cord-318495-1w74wf02	106	15	with	with	IN
cord-318495-1w74wf02	106	16	the	the	DT
cord-318495-1w74wf02	106	17	generation	generation	NN
cord-318495-1w74wf02	106	18	of	of	IN
cord-318495-1w74wf02	106	19	DVGs	dvg	NNS
cord-318495-1w74wf02	106	20	.	.	.
cord-318495-1w74wf02	107	1	Mutations	mutation	NNS
cord-318495-1w74wf02	107	2	in	in	IN
cord-318495-1w74wf02	107	3	the	the	DT
cord-318495-1w74wf02	107	4	influenza	influenza	NN
cord-318495-1w74wf02	107	5	virus	virus	NN
cord-318495-1w74wf02	107	6	nuclear	nuclear	JJ
cord-318495-1w74wf02	107	7	export	export	NN
cord-318495-1w74wf02	107	8	protein	protein	NN
cord-318495-1w74wf02	107	9	(	(	-LRB-
cord-318495-1w74wf02	107	10	NEP	NEP	NNP
cord-318495-1w74wf02	107	11	,	,	,
cord-318495-1w74wf02	107	12	also	also	RB
cord-318495-1w74wf02	107	13	known	know	VBN
cord-318495-1w74wf02	107	14	as	as	IN
cord-318495-1w74wf02	107	15	NS2	NS2	NNP
cord-318495-1w74wf02	107	16	)	)	-RRB-
cord-318495-1w74wf02	107	17	,	,	,
cord-318495-1w74wf02	107	18	which	which	WDT
cord-318495-1w74wf02	107	19	regulates	regulate	VBZ
cord-318495-1w74wf02	107	20	the	the	DT
cord-318495-1w74wf02	107	21	synthesis	synthesis	NN
cord-318495-1w74wf02	107	22	of	of	IN
cord-318495-1w74wf02	107	23	complementary	complementary	JJ
cord-318495-1w74wf02	107	24	RNA	RNA	NNP
cord-318495-1w74wf02	107	25	,	,	,
cord-318495-1w74wf02	107	26	result	result	VB
cord-318495-1w74wf02	107	27	in	in	IN
cord-318495-1w74wf02	107	28	enhanced	enhance	VBN
cord-318495-1w74wf02	107	29	DVG	DVG	NNP
cord-318495-1w74wf02	107	30	production	production	NN
cord-318495-1w74wf02	107	31	66	66	CD
cord-318495-1w74wf02	107	32	.	.	.
cord-318495-1w74wf02	108	1	Similarly	similarly	RB
cord-318495-1w74wf02	108	2	,	,	,
cord-318495-1w74wf02	108	3	deletion	deletion	NN
cord-318495-1w74wf02	108	4	or	or	CC
cord-318495-1w74wf02	108	5	mutations	mutation	NNS
cord-318495-1w74wf02	108	6	of	of	IN
cord-318495-1w74wf02	108	7	the	the	DT
cord-318495-1w74wf02	108	8	paramyxovirus	paramyxovirus	NNP
cord-318495-1w74wf02	108	9	C	C	NNP
cord-318495-1w74wf02	108	10	proteins	protein	NNS
cord-318495-1w74wf02	108	11	that	that	WDT
cord-318495-1w74wf02	108	12	regulate	regulate	VBP
cord-318495-1w74wf02	108	13	template	template	NN
cord-318495-1w74wf02	108	14	switching	switch	VBG
cord-318495-1w74wf02	108	15	from	from	IN
cord-318495-1w74wf02	108	16	antigenomic	antigenomic	RB
cord-318495-1w74wf02	108	17	to	to	IN
cord-318495-1w74wf02	108	18	genomic	genomic	JJ
cord-318495-1w74wf02	108	19	replication	replication	NN
cord-318495-1w74wf02	108	20	result	result	NN
cord-318495-1w74wf02	108	21	in	in	IN
cord-318495-1w74wf02	108	22	enhanced	enhanced	JJ
cord-318495-1w74wf02	108	23	copy	copy	NN
cord-318495-1w74wf02	108	24	-	-	HYPH
cord-318495-1w74wf02	108	25	back	back	NN
cord-318495-1w74wf02	108	26	DVG	DVG	NNP
cord-318495-1w74wf02	108	27	production	production	NN
cord-318495-1w74wf02	108	28	53	53	CD
cord-318495-1w74wf02	108	29	,	,	,
cord-318495-1w74wf02	108	30	56	56	CD
cord-318495-1w74wf02	109	1	(	(	-LRB-
cord-318495-1w74wf02	109	2	Fig	Fig	NNP
cord-318495-1w74wf02	109	3	.	.	.
cord-318495-1w74wf02	109	4	2a	2a	CD
cord-318495-1w74wf02	109	5	)	)	-RRB-
cord-318495-1w74wf02	109	6	.	.	.
cord-318495-1w74wf02	110	1	Curiously	curiously	RB
cord-318495-1w74wf02	110	2	,	,	,
cord-318495-1w74wf02	110	3	in	in	IN
cord-318495-1w74wf02	110	4	infections	infection	NNS
cord-318495-1w74wf02	110	5	with	with	IN
cord-318495-1w74wf02	110	6	influenza	influenza	NN
cord-318495-1w74wf02	110	7	virus	virus	NN
cord-318495-1w74wf02	110	8	lacking	lack	VBG
cord-318495-1w74wf02	110	9	NEP	NEP	NNP
cord-318495-1w74wf02	110	10	or	or	CC
cord-318495-1w74wf02	110	11	paramyxovirus	paramyxovirus	NN
cord-318495-1w74wf02	110	12	lacking	lack	VBG
cord-318495-1w74wf02	110	13	C	C	NNP
cord-318495-1w74wf02	110	14	,	,	,
cord-318495-1w74wf02	110	15	DVG	DVG	NNP
cord-318495-1w74wf02	110	16	production	production	NN
cord-318495-1w74wf02	110	17	is	be	VBZ
cord-318495-1w74wf02	110	18	observed	observe	VBN
cord-318495-1w74wf02	110	19	in	in	IN
cord-318495-1w74wf02	110	20	conditions	condition	NNS
cord-318495-1w74wf02	110	21	that	that	WDT
cord-318495-1w74wf02	110	22	normally	normally	RB
cord-318495-1w74wf02	110	23	restrict	restrict	VBP
cord-318495-1w74wf02	110	24	the	the	DT
cord-318495-1w74wf02	110	25	generation	generation	NN
cord-318495-1w74wf02	110	26	of	of	IN
cord-318495-1w74wf02	110	27	DVGs	dvg	NNS
cord-318495-1w74wf02	110	28	,	,	,
cord-318495-1w74wf02	110	29	such	such	JJ
cord-318495-1w74wf02	110	30	as	as	IN
cord-318495-1w74wf02	110	31	infections	infection	NNS
cord-318495-1w74wf02	110	32	at	at	IN
cord-318495-1w74wf02	110	33	low	low	JJ
cord-318495-1w74wf02	110	34	MOI	MOI	NNP
cord-318495-1w74wf02	110	35	.	.	.
cord-318495-1w74wf02	111	1	It	-PRON-	PRP
cord-318495-1w74wf02	111	2	is	be	VBZ
cord-318495-1w74wf02	111	3	possible	possible	JJ
cord-318495-1w74wf02	111	4	that	that	IN
cord-318495-1w74wf02	111	5	the	the	DT
cord-318495-1w74wf02	111	6	enhanced	enhanced	JJ
cord-318495-1w74wf02	111	7	production	production	NN
cord-318495-1w74wf02	111	8	of	of	IN
cord-318495-1w74wf02	111	9	copy	copy	NN
cord-318495-1w74wf02	111	10	-	-	HYPH
cord-318495-1w74wf02	111	11	back	back	NN
cord-318495-1w74wf02	111	12	DVGs	dvg	NNS
cord-318495-1w74wf02	111	13	in	in	IN
cord-318495-1w74wf02	111	14	these	these	DT
cord-318495-1w74wf02	111	15	situations	situation	NNS
cord-318495-1w74wf02	111	16	is	be	VBZ
cord-318495-1w74wf02	111	17	related	relate	VBN
cord-318495-1w74wf02	111	18	to	to	IN
cord-318495-1w74wf02	111	19	higher	high	JJR
cord-318495-1w74wf02	111	20	template	template	NN
cord-318495-1w74wf02	111	21	availability	availability	NN
cord-318495-1w74wf02	111	22	or	or	CC
cord-318495-1w74wf02	111	23	to	to	IN
cord-318495-1w74wf02	111	24	an	an	DT
cord-318495-1w74wf02	111	25	indirect	indirect	JJ
cord-318495-1w74wf02	111	26	effect	effect	NN
cord-318495-1w74wf02	111	27	of	of	IN
cord-318495-1w74wf02	111	28	viral	viral	JJ
cord-318495-1w74wf02	111	29	polymerase	polymerase	NN
cord-318495-1w74wf02	111	30	activity	activity	NN
cord-318495-1w74wf02	111	31	,	,	,
cord-318495-1w74wf02	111	32	but	but	CC
cord-318495-1w74wf02	111	33	the	the	DT
cord-318495-1w74wf02	111	34	precise	precise	JJ
cord-318495-1w74wf02	111	35	mechanism	mechanism	NN
cord-318495-1w74wf02	111	36	remains	remain	VBZ
cord-318495-1w74wf02	111	37	to	to	TO
cord-318495-1w74wf02	111	38	be	be	VB
cord-318495-1w74wf02	111	39	established	establish	VBN
cord-318495-1w74wf02	111	40	.	.	.
cord-318495-1w74wf02	112	1	In	in	IN
cord-318495-1w74wf02	112	2	addition	addition	NN
cord-318495-1w74wf02	112	3	,	,	,
cord-318495-1w74wf02	112	4	a	a	DT
cord-318495-1w74wf02	112	5	single	single	JJ
cord-318495-1w74wf02	112	6	amino	amino	NN
cord-318495-1w74wf02	112	7	acid	acid	NN
cord-318495-1w74wf02	112	8	mutation	mutation	NN
cord-318495-1w74wf02	112	9	in	in	IN
cord-318495-1w74wf02	112	10	the	the	DT
cord-318495-1w74wf02	112	11	Sendai	Sendai	NNP
cord-318495-1w74wf02	112	12	virus	virus	NN
cord-318495-1w74wf02	112	13	(	(	-LRB-
cord-318495-1w74wf02	112	14	SeV	SeV	NNP
cord-318495-1w74wf02	112	15	)	)	-RRB-
cord-318495-1w74wf02	112	16	nucleoprotein	nucleoprotein	NNP
cord-318495-1w74wf02	112	17	that	that	WDT
cord-318495-1w74wf02	112	18	reduced	reduce	VBD
cord-318495-1w74wf02	112	19	the	the	DT
cord-318495-1w74wf02	112	20	density	density	NN
cord-318495-1w74wf02	112	21	of	of	IN
cord-318495-1w74wf02	112	22	the	the	DT
cord-318495-1w74wf02	112	23	ribonucleprotein	ribonucleprotein	NNP
cord-318495-1w74wf02	112	24	associates	associate	NNS
cord-318495-1w74wf02	112	25	with	with	IN
cord-318495-1w74wf02	112	26	DVG	DVG	NNP
cord-318495-1w74wf02	112	27	generation	generation	NN
cord-318495-1w74wf02	112	28	67	67	CD
cord-318495-1w74wf02	113	1	(	(	-LRB-
cord-318495-1w74wf02	113	2	Fig	Fig	NNP
cord-318495-1w74wf02	113	3	.	.	.
cord-318495-1w74wf02	113	4	2b	2b	NNP
cord-318495-1w74wf02	113	5	)	)	-RRB-
cord-318495-1w74wf02	113	6	.	.	.
cord-318495-1w74wf02	114	1	Lastly	lastly	RB
cord-318495-1w74wf02	114	2	,	,	,
cord-318495-1w74wf02	114	3	in	in	IN
cord-318495-1w74wf02	114	4	lymphocytic	lymphocytic	JJ
cord-318495-1w74wf02	114	5	choriomeningitis	choriomeningitis	NNP
cord-318495-1w74wf02	114	6	mammarenavirus	mammarenavirus	NNP
cord-318495-1w74wf02	114	7	(	(	-LRB-
cord-318495-1w74wf02	114	8	LCMV	LCMV	NNP
cord-318495-1w74wf02	114	9	)	)	-RRB-
cord-318495-1w74wf02	114	10	infection	infection	NN
cord-318495-1w74wf02	114	11	,	,	,
cord-318495-1w74wf02	114	12	the	the	DT
cord-318495-1w74wf02	114	13	PPXY	PPXY	NNP
cord-318495-1w74wf02	114	14	domain	domain	NN
cord-318495-1w74wf02	114	15	encoded	encode	VBN
cord-318495-1w74wf02	114	16	within	within	IN
cord-318495-1w74wf02	114	17	the	the	DT
cord-318495-1w74wf02	114	18	matrix	matrix	NN
cord-318495-1w74wf02	114	19	protein	protein	NN
cord-318495-1w74wf02	114	20	drives	drive	VBZ
cord-318495-1w74wf02	114	21	the	the	DT
cord-318495-1w74wf02	114	22	production	production	NN
cord-318495-1w74wf02	114	23	of	of	IN
cord-318495-1w74wf02	114	24	viral	viral	JJ
cord-318495-1w74wf02	114	25	particles	particle	NNS
cord-318495-1w74wf02	114	26	containing	contain	VBG
cord-318495-1w74wf02	114	27	defective	defective	JJ
cord-318495-1w74wf02	114	28	genomes	genome	NNS
cord-318495-1w74wf02	114	29	,	,	,
cord-318495-1w74wf02	114	30	but	but	CC
cord-318495-1w74wf02	114	31	not	not	RB
cord-318495-1w74wf02	114	32	those	those	DT
cord-318495-1w74wf02	114	33	containing	contain	VBG
cord-318495-1w74wf02	114	34	standard	standard	JJ
cord-318495-1w74wf02	114	35	genomes	genome	NNS
cord-318495-1w74wf02	114	36	68	68	CD
cord-318495-1w74wf02	114	37	(	(	-LRB-
cord-318495-1w74wf02	114	38	Fig	Fig	NNP
cord-318495-1w74wf02	114	39	.	.	.
cord-318495-1w74wf02	114	40	2c	2c	NNP
cord-318495-1w74wf02	114	41	)	)	-RRB-
cord-318495-1w74wf02	114	42	.	.	.
cord-318495-1w74wf02	115	1	Replication	replication	NN
cord-318495-1w74wf02	115	2	-	-	HYPH
cord-318495-1w74wf02	115	3	driven	drive	VBN
cord-318495-1w74wf02	115	4	template	template	NN
cord-318495-1w74wf02	115	5	-	-	HYPH
cord-318495-1w74wf02	115	6	switching	switching	NN
cord-318495-1w74wf02	115	7	.	.	.
cord-318495-1w74wf02	116	1	RNA	RNA	NNP
cord-318495-1w74wf02	116	2	recombination	recombination	NN
cord-318495-1w74wf02	116	3	is	be	VBZ
cord-318495-1w74wf02	116	4	a	a	DT
cord-318495-1w74wf02	116	5	major	major	JJ
cord-318495-1w74wf02	116	6	driver	driver	NN
cord-318495-1w74wf02	116	7	of	of	IN
cord-318495-1w74wf02	116	8	deletion	deletion	NN
cord-318495-1w74wf02	116	9	DVG	DVG	NNP
cord-318495-1w74wf02	116	10	formation	formation	NN
cord-318495-1w74wf02	116	11	.	.	.
cord-318495-1w74wf02	117	1	A	a	DT
cord-318495-1w74wf02	117	2	predominant	predominant	JJ
cord-318495-1w74wf02	117	3	model	model	NN
cord-318495-1w74wf02	117	4	proposes	propose	VBZ
cord-318495-1w74wf02	117	5	that	that	IN
cord-318495-1w74wf02	117	6	sequences	sequence	NNS
cord-318495-1w74wf02	117	7	at	at	IN
cord-318495-1w74wf02	117	8	the	the	DT
cord-318495-1w74wf02	117	9	break	break	NN
cord-318495-1w74wf02	117	10	point	point	NN
cord-318495-1w74wf02	117	11	or	or	CC
cord-318495-1w74wf02	117	12	structural	structural	JJ
cord-318495-1w74wf02	117	13	signals	signal	NNS
cord-318495-1w74wf02	117	14	in	in	IN
cord-318495-1w74wf02	117	15	the	the	DT
cord-318495-1w74wf02	117	16	template	template	NN
cord-318495-1w74wf02	117	17	RNA	RNA	NNP
cord-318495-1w74wf02	117	18	promote	promote	VBP
cord-318495-1w74wf02	117	19	the	the	DT
cord-318495-1w74wf02	117	20	replicase	replicase	NN
cord-318495-1w74wf02	117	21	to	to	TO
cord-318495-1w74wf02	117	22	switch	switch	VB
cord-318495-1w74wf02	117	23	to	to	IN
cord-318495-1w74wf02	117	24	the	the	DT
cord-318495-1w74wf02	117	25	acceptor	acceptor	NN
cord-318495-1w74wf02	117	26	RNA	RNA	NNP
cord-318495-1w74wf02	117	27	and	and	CC
cord-318495-1w74wf02	117	28	resume	resume	VB
cord-318495-1w74wf02	117	29	synthesis	synthesis	NN
cord-318495-1w74wf02	117	30	(	(	-LRB-
cord-318495-1w74wf02	117	31	Fig	Fig	NNP
cord-318495-1w74wf02	117	32	.	.	.
cord-318495-1w74wf02	117	33	2d	2d	NNP
cord-318495-1w74wf02	117	34	)	)	-RRB-
cord-318495-1w74wf02	117	35	.	.	.
cord-318495-1w74wf02	118	1	Replicase	Replicase	NNP
cord-318495-1w74wf02	118	2	-	-	HYPH
cord-318495-1w74wf02	118	3	driven	drive	VBN
cord-318495-1w74wf02	118	4	recombination	recombination	NN
cord-318495-1w74wf02	118	5	was	be	VBD
cord-318495-1w74wf02	118	6	proven	prove	VBN
cord-318495-1w74wf02	118	7	in	in	IN
cord-318495-1w74wf02	118	8	biochemical	biochemical	JJ
cord-318495-1w74wf02	118	9	assays	assay	NNS
cord-318495-1w74wf02	118	10	using	use	VBG
cord-318495-1w74wf02	118	11	RdRPs	RdRPs	NNP
cord-318495-1w74wf02	118	12	of	of	IN
cord-318495-1w74wf02	118	13	a	a	DT
cord-318495-1w74wf02	118	14	large	large	JJ
cord-318495-1w74wf02	118	15	number	number	NN
cord-318495-1w74wf02	118	16	of	of	IN
cord-318495-1w74wf02	118	17	RNA	RNA	NNP
cord-318495-1w74wf02	118	18	viruses	virus	NNS
cord-318495-1w74wf02	118	19	[	[	-LRB-
cord-318495-1w74wf02	118	20	69	69	CD
cord-318495-1w74wf02	118	21	]	]	-RRB-
cord-318495-1w74wf02	118	22	[	[	-LRB-
cord-318495-1w74wf02	118	23	70	70	CD
cord-318495-1w74wf02	118	24	]	]	-RRB-
cord-318495-1w74wf02	118	25	[	[	-LRB-
cord-318495-1w74wf02	118	26	71	71	CD
cord-318495-1w74wf02	118	27	]	]	-RRB-
cord-318495-1w74wf02	118	28	.	.	.
cord-318495-1w74wf02	119	1	Variations	variation	NNS
cord-318495-1w74wf02	119	2	of	of	IN
cord-318495-1w74wf02	119	3	this	this	DT
cord-318495-1w74wf02	119	4	model	model	NN
cord-318495-1w74wf02	119	5	include	include	VBP
cord-318495-1w74wf02	119	6	the	the	DT
cord-318495-1w74wf02	119	7	forced	force	VBN
cord-318495-1w74wf02	119	8	template	template	NN
cord-318495-1w74wf02	119	9	switch	switch	NN
cord-318495-1w74wf02	119	10	mechanism	mechanism	NN
cord-318495-1w74wf02	119	11	in	in	IN
cord-318495-1w74wf02	119	12	which	which	WDT
cord-318495-1w74wf02	119	13	the	the	DT
cord-318495-1w74wf02	119	14	replicase	replicase	NN
cord-318495-1w74wf02	119	15	switches	switch	VBZ
cord-318495-1w74wf02	119	16	template	template	NN
cord-318495-1w74wf02	119	17	after	after	IN
cord-318495-1w74wf02	119	18	encountering	encounter	VBG
cord-318495-1w74wf02	119	19	the	the	DT
cord-318495-1w74wf02	119	20	5′	5′	CD
cord-318495-1w74wf02	119	21	end	end	NN
cord-318495-1w74wf02	119	22	of	of	IN
cord-318495-1w74wf02	119	23	the	the	DT
cord-318495-1w74wf02	119	24	template	template	NN
cord-318495-1w74wf02	119	25	generating	generate	VBG
cord-318495-1w74wf02	119	26	headto	headto	NN
cord-318495-1w74wf02	119	27	-	-	HYPH
cord-318495-1w74wf02	119	28	tail	tail	NN
cord-318495-1w74wf02	119	29	RNA	RNA	NNP
cord-318495-1w74wf02	119	30	dimers	dimer	NNS
cord-318495-1w74wf02	119	31	.	.	.
cord-318495-1w74wf02	120	1	If	if	IN
cord-318495-1w74wf02	120	2	the	the	DT
cord-318495-1w74wf02	120	3	templates	template	NNS
cord-318495-1w74wf02	120	4	are	be	VBP
cord-318495-1w74wf02	120	5	DVGs	dvg	NNS
cord-318495-1w74wf02	120	6	,	,	,
cord-318495-1w74wf02	120	7	these	these	DT
cord-318495-1w74wf02	120	8	would	would	MD
cord-318495-1w74wf02	120	9	lead	lead	VB
cord-318495-1w74wf02	120	10	to	to	IN
cord-318495-1w74wf02	120	11	head	head	NN
cord-318495-1w74wf02	120	12	-	-	HYPH
cord-318495-1w74wf02	120	13	to	to	IN
cord-318495-1w74wf02	120	14	-	-	HYPH
cord-318495-1w74wf02	120	15	tail	tail	NN
cord-318495-1w74wf02	120	16	DVG	DVG	NNP
cord-318495-1w74wf02	120	17	dimers	dimer	NNS
cord-318495-1w74wf02	120	18	.	.	.
cord-318495-1w74wf02	121	1	The	the	DT
cord-318495-1w74wf02	121	2	5′	5′	CD
cord-318495-1w74wf02	121	3	end	end	NN
cord-318495-1w74wf02	121	4	could	could	MD
cord-318495-1w74wf02	121	5	also	also	RB
cord-318495-1w74wf02	121	6	be	be	VB
cord-318495-1w74wf02	121	7	modified	modify	VBN
cord-318495-1w74wf02	121	8	by	by	IN
cord-318495-1w74wf02	121	9	endo	endo	NN
cord-318495-1w74wf02	121	10	-	-	,
cord-318495-1w74wf02	121	11	or	or	CC
cord-318495-1w74wf02	121	12	exo	exo	NN
cord-318495-1w74wf02	121	13	-	-	HYPH
cord-318495-1w74wf02	121	14	nucleases	nuclease	NNS
cord-318495-1w74wf02	121	15	,	,	,
cord-318495-1w74wf02	121	16	leading	lead	VBG
cord-318495-1w74wf02	121	17	to	to	IN
cord-318495-1w74wf02	121	18	new	new	JJ
cord-318495-1w74wf02	121	19	versions	version	NNS
cord-318495-1w74wf02	121	20	of	of	IN
cord-318495-1w74wf02	121	21	these	these	DT
cord-318495-1w74wf02	121	22	genomes	genome	NNS
cord-318495-1w74wf02	121	23	72	72	CD
cord-318495-1w74wf02	121	24	.	.	.
cord-318495-1w74wf02	122	1	RNA	RNA	NNP
cord-318495-1w74wf02	122	2	editing	editing	NN
cord-318495-1w74wf02	122	3	as	as	IN
cord-318495-1w74wf02	122	4	a	a	DT
cord-318495-1w74wf02	122	5	driver	driver	NN
cord-318495-1w74wf02	122	6	of	of	IN
cord-318495-1w74wf02	122	7	DVG	DVG	NNP
cord-318495-1w74wf02	122	8	diversity	diversity	NN
cord-318495-1w74wf02	122	9	.	.	.
cord-318495-1w74wf02	123	1	Editing	editing	NN
cord-318495-1w74wf02	123	2	of	of	IN
cord-318495-1w74wf02	123	3	viral	viral	JJ
cord-318495-1w74wf02	123	4	RNA	RNA	NNP
cord-318495-1w74wf02	123	5	leads	lead	VBZ
cord-318495-1w74wf02	123	6	to	to	IN
cord-318495-1w74wf02	123	7	hypermutations	hypermutation	NNS
cord-318495-1w74wf02	123	8	and	and	CC
cord-318495-1w74wf02	123	9	can	can	MD
cord-318495-1w74wf02	123	10	result	result	VB
cord-318495-1w74wf02	123	11	in	in	IN
cord-318495-1w74wf02	123	12	the	the	DT
cord-318495-1w74wf02	123	13	generation	generation	NN
cord-318495-1w74wf02	123	14	of	of	IN
cord-318495-1w74wf02	123	15	DVGs	dvg	NNS
cord-318495-1w74wf02	123	16	,	,	,
cord-318495-1w74wf02	123	17	as	as	IN
cord-318495-1w74wf02	123	18	reported	report	VBN
cord-318495-1w74wf02	123	19	in	in	IN
cord-318495-1w74wf02	123	20	persistent	persistent	JJ
cord-318495-1w74wf02	123	21	measles	measle	NNS
cord-318495-1w74wf02	123	22	infections	infection	NNS
cord-318495-1w74wf02	123	23	31	31	CD
cord-318495-1w74wf02	123	24	.	.	.
cord-318495-1w74wf02	124	1	In	in	IN
cord-318495-1w74wf02	124	2	addition	addition	NN
cord-318495-1w74wf02	124	3	,	,	,
cord-318495-1w74wf02	124	4	a	a	DT
cord-318495-1w74wf02	124	5	high	high	JJ
cord-318495-1w74wf02	124	6	rate	rate	NN
cord-318495-1w74wf02	124	7	of	of	IN
cord-318495-1w74wf02	124	8	viral	viral	JJ
cord-318495-1w74wf02	124	9	adenine	adenine	NN
cord-318495-1w74wf02	124	10	-	-	HYPH
cord-318495-1w74wf02	124	11	to	to	IN
cord-318495-1w74wf02	124	12	-	-	HYPH
cord-318495-1w74wf02	124	13	guanine	guanine	NN
cord-318495-1w74wf02	124	14	(	(	-LRB-
cord-318495-1w74wf02	124	15	or	or	CC
cord-318495-1w74wf02	124	16	uracil	uracil	NN
cord-318495-1w74wf02	124	17	-	-	HYPH
cord-318495-1w74wf02	124	18	to	to	IN
cord-318495-1w74wf02	124	19	-	-	HYPH
cord-318495-1w74wf02	124	20	cytosine	cytosine	NN
cord-318495-1w74wf02	124	21	)	)	-RRB-
cord-318495-1w74wf02	124	22	RNA	rna	NN
cord-318495-1w74wf02	124	23	editing	editing	NN
cord-318495-1w74wf02	124	24	by	by	IN
cord-318495-1w74wf02	124	25	adenosine	adenosine	NN
cord-318495-1w74wf02	124	26	deaminase	deaminase	NN
cord-318495-1w74wf02	124	27	acting	act	VBG
cord-318495-1w74wf02	124	28	on	on	IN
cord-318495-1w74wf02	124	29	RNA	RNA	NNP
cord-318495-1w74wf02	124	30	occurs	occur	VBZ
cord-318495-1w74wf02	124	31	in	in	IN
cord-318495-1w74wf02	124	32	DVGs	dvg	NNS
cord-318495-1w74wf02	124	33	from	from	IN
cord-318495-1w74wf02	124	34	VSV	VSV	NNP
cord-318495-1w74wf02	124	35	,	,	,
cord-318495-1w74wf02	124	36	human	human	JJ
cord-318495-1w74wf02	124	37	metapneumovirus	metapneumovirus	NNP
cord-318495-1w74wf02	124	38	and	and	CC
cord-318495-1w74wf02	124	39	MeV	MeV	NNP
cord-318495-1w74wf02	124	40	38	38	CD
cord-318495-1w74wf02	124	41	,	,	,
cord-318495-1w74wf02	124	42	52	52	CD
cord-318495-1w74wf02	124	43	,	,	,
cord-318495-1w74wf02	124	44	53	53	CD
cord-318495-1w74wf02	124	45	.	.	.
cord-318495-1w74wf02	125	1	In	in	IN
cord-318495-1w74wf02	125	2	some	some	DT
cord-318495-1w74wf02	125	3	cases	case	NNS
cord-318495-1w74wf02	125	4	,	,	,
cord-318495-1w74wf02	125	5	RNA	RNA	NNP
cord-318495-1w74wf02	125	6	editing	editing	NN
cord-318495-1w74wf02	125	7	regulates	regulate	VBZ
cord-318495-1w74wf02	125	8	the	the	DT
cord-318495-1w74wf02	125	9	immunostimulatory	immunostimulatory	JJ
cord-318495-1w74wf02	125	10	potential	potential	NN
cord-318495-1w74wf02	125	11	of	of	IN
cord-318495-1w74wf02	125	12	DVGs	dvg	NNS
cord-318495-1w74wf02	125	13	53	53	CD
cord-318495-1w74wf02	125	14	.	.	.
cord-318495-1w74wf02	126	1	However	however	RB
cord-318495-1w74wf02	126	2	,	,	,
cord-318495-1w74wf02	126	3	the	the	DT
cord-318495-1w74wf02	126	4	impact	impact	NN
cord-318495-1w74wf02	126	5	of	of	IN
cord-318495-1w74wf02	126	6	DVG	DVG	NNP
cord-318495-1w74wf02	126	7	editing	editing	NN
cord-318495-1w74wf02	126	8	on	on	IN
cord-318495-1w74wf02	126	9	viral	viral	JJ
cord-318495-1w74wf02	126	10	replication	replication	NN
cord-318495-1w74wf02	126	11	seems	seem	VBZ
cord-318495-1w74wf02	126	12	to	to	TO
cord-318495-1w74wf02	126	13	be	be	VB
cord-318495-1w74wf02	126	14	virus	virus	NN
cord-318495-1w74wf02	126	15	-	-	HYPH
cord-318495-1w74wf02	126	16	specific	specific	JJ
cord-318495-1w74wf02	126	17	73	73	CD
cord-318495-1w74wf02	126	18	.	.	.
cord-318495-1w74wf02	127	1	Whether	whether	IN
cord-318495-1w74wf02	127	2	DVGs	dvg	NNS
cord-318495-1w74wf02	127	3	have	have	VBP
cord-318495-1w74wf02	127	4	a	a	DT
cord-318495-1w74wf02	127	5	higher	high	JJR
cord-318495-1w74wf02	127	6	rate	rate	NN
cord-318495-1w74wf02	127	7	of	of	IN
cord-318495-1w74wf02	127	8	editing	editing	NN
cord-318495-1w74wf02	127	9	than	than	IN
cord-318495-1w74wf02	127	10	the	the	DT
cord-318495-1w74wf02	127	11	standard	standard	JJ
cord-318495-1w74wf02	127	12	viral	viral	JJ
cord-318495-1w74wf02	127	13	genome	genome	NN
cord-318495-1w74wf02	127	14	,	,	,
cord-318495-1w74wf02	127	15	as	as	RB
cord-318495-1w74wf02	127	16	well	well	RB
cord-318495-1w74wf02	127	17	as	as	IN
cord-318495-1w74wf02	127	18	the	the	DT
cord-318495-1w74wf02	127	19	impact	impact	NN
cord-318495-1w74wf02	127	20	of	of	IN
cord-318495-1w74wf02	127	21	editing	edit	VBG
cord-318495-1w74wf02	127	22	generated	generate	VBN
cord-318495-1w74wf02	127	23	diversity	diversity	NN
cord-318495-1w74wf02	127	24	in	in	IN
cord-318495-1w74wf02	127	25	DVG	DVG	NNP
cord-318495-1w74wf02	127	26	evolution	evolution	NN
cord-318495-1w74wf02	127	27	and	and	CC
cord-318495-1w74wf02	127	28	selection	selection	NN
cord-318495-1w74wf02	127	29	,	,	,
cord-318495-1w74wf02	127	30	remains	remain	VBZ
cord-318495-1w74wf02	127	31	to	to	TO
cord-318495-1w74wf02	127	32	be	be	VB
cord-318495-1w74wf02	127	33	determined	determine	VBN
cord-318495-1w74wf02	127	34	.	.	.
cord-318495-1w74wf02	128	1	DVGs	dvg	NNS
cord-318495-1w74wf02	128	2	have	have	VBP
cord-318495-1w74wf02	128	3	three	three	CD
cord-318495-1w74wf02	128	4	well	well	RB
cord-318495-1w74wf02	128	5	-	-	HYPH
cord-318495-1w74wf02	128	6	described	describe	VBN
cord-318495-1w74wf02	128	7	functions	function	NNS
cord-318495-1w74wf02	128	8	that	that	WDT
cord-318495-1w74wf02	128	9	relate	relate	VBP
cord-318495-1w74wf02	128	10	to	to	IN
cord-318495-1w74wf02	128	11	their	-PRON-	PRP$
cord-318495-1w74wf02	128	12	role	role	NN
cord-318495-1w74wf02	128	13	in	in	IN
cord-318495-1w74wf02	128	14	pathogenesis	pathogenesis	NN
cord-318495-1w74wf02	128	15	:	:	:
cord-318495-1w74wf02	128	16	interference	interference	NN
cord-318495-1w74wf02	128	17	with	with	IN
cord-318495-1w74wf02	128	18	standard	standard	JJ
cord-318495-1w74wf02	128	19	viral	viral	JJ
cord-318495-1w74wf02	128	20	replication	replication	NN
cord-318495-1w74wf02	128	21	,	,	,
cord-318495-1w74wf02	128	22	immunostimulation	immunostimulation	NN
cord-318495-1w74wf02	128	23	and	and	CC
cord-318495-1w74wf02	128	24	establishment	establishment	NN
cord-318495-1w74wf02	128	25	of	of	IN
cord-318495-1w74wf02	128	26	viral	viral	JJ
cord-318495-1w74wf02	128	27	persistence	persistence	NN
cord-318495-1w74wf02	128	28	(	(	-LRB-
cord-318495-1w74wf02	128	29	Fig	Fig	NNP
cord-318495-1w74wf02	128	30	.	.	.
cord-318495-1w74wf02	128	31	3a	3a	NNP
cord-318495-1w74wf02	128	32	)	)	-RRB-
cord-318495-1w74wf02	128	33	.	.	.
cord-318495-1w74wf02	129	1	Interference	interference	NN
cord-318495-1w74wf02	129	2	with	with	IN
cord-318495-1w74wf02	129	3	viral	viral	JJ
cord-318495-1w74wf02	129	4	replication	replication	NN
cord-318495-1w74wf02	129	5	and	and	CC
cord-318495-1w74wf02	129	6	viral	viral	JJ
cord-318495-1w74wf02	129	7	production	production	NN
cord-318495-1w74wf02	129	8	.	.	.
cord-318495-1w74wf02	130	1	DVGs	dvg	NNS
cord-318495-1w74wf02	130	2	were	be	VBD
cord-318495-1w74wf02	130	3	discovered	discover	VBN
cord-318495-1w74wf02	130	4	during	during	IN
cord-318495-1w74wf02	130	5	the	the	DT
cord-318495-1w74wf02	130	6	search	search	NN
cord-318495-1w74wf02	130	7	for	for	IN
cord-318495-1w74wf02	130	8	factors	factor	NNS
cord-318495-1w74wf02	130	9	responsible	responsible	JJ
cord-318495-1w74wf02	130	10	for	for	IN
cord-318495-1w74wf02	130	11	reduced	reduce	VBN
cord-318495-1w74wf02	130	12	infectivity	infectivity	NN
cord-318495-1w74wf02	130	13	of	of	IN
cord-318495-1w74wf02	130	14	influenza	influenza	NN
cord-318495-1w74wf02	130	15	virus	virus	NN
cord-318495-1w74wf02	130	16	after	after	IN
cord-318495-1w74wf02	130	17	passages	passage	NNS
cord-318495-1w74wf02	130	18	at	at	IN
cord-318495-1w74wf02	130	19	high	high	JJ
cord-318495-1w74wf02	130	20	titers	titer	NNS
cord-318495-1w74wf02	130	21	2	2	CD
cord-318495-1w74wf02	130	22	.	.	.
cord-318495-1w74wf02	131	1	DVGs	dvg	NNS
cord-318495-1w74wf02	131	2	with	with	IN
cord-318495-1w74wf02	131	3	the	the	DT
cord-318495-1w74wf02	131	4	ability	ability	NN
cord-318495-1w74wf02	131	5	to	to	TO
cord-318495-1w74wf02	131	6	interfere	interfere	VB
cord-318495-1w74wf02	131	7	with	with	IN
cord-318495-1w74wf02	131	8	the	the	DT
cord-318495-1w74wf02	131	9	replication	replication	NN
cord-318495-1w74wf02	131	10	of	of	IN
cord-318495-1w74wf02	131	11	their	-PRON-	PRP$
cord-318495-1w74wf02	131	12	parental	parental	JJ
cord-318495-1w74wf02	131	13	virus	virus	NN
cord-318495-1w74wf02	131	14	both	both	CC
cord-318495-1w74wf02	131	15	in	in	IN
cord-318495-1w74wf02	131	16	vitro	vitro	FW
cord-318495-1w74wf02	131	17	and	and	CC
cord-318495-1w74wf02	131	18	in	in	IN
cord-318495-1w74wf02	131	19	vivo	vivo	NNP
cord-318495-1w74wf02	131	20	are	be	VBP
cord-318495-1w74wf02	131	21	found	find	VBN
cord-318495-1w74wf02	131	22	in	in	IN
cord-318495-1w74wf02	131	23	most	most	RBS
cord-318495-1w74wf02	131	24	positive	positive	JJ
cord-318495-1w74wf02	131	25	and	and	CC
cord-318495-1w74wf02	131	26	negative	negative	JJ
cord-318495-1w74wf02	131	27	-	-	HYPH
cord-318495-1w74wf02	131	28	sense	sense	NN
cord-318495-1w74wf02	131	29	(	(	-LRB-
cord-318495-1w74wf02	131	30	ns)RNA	ns)RNA	NNS
cord-318495-1w74wf02	131	31	viruses	virus	NNS
cord-318495-1w74wf02	131	32	54	54	CD
cord-318495-1w74wf02	131	33	,	,	,
cord-318495-1w74wf02	131	34	[	[	-LRB-
cord-318495-1w74wf02	131	35	74	74	CD
cord-318495-1w74wf02	131	36	]	]	-RRB-
cord-318495-1w74wf02	131	37	[	[	-LRB-
cord-318495-1w74wf02	131	38	75	75	CD
cord-318495-1w74wf02	131	39	]	]	-RRB-
cord-318495-1w74wf02	131	40	[	[	-LRB-
cord-318495-1w74wf02	131	41	76	76	CD
cord-318495-1w74wf02	131	42	]	]	-RRB-
cord-318495-1w74wf02	131	43	[	[	-LRB-
cord-318495-1w74wf02	131	44	77	77	CD
cord-318495-1w74wf02	131	45	]	]	-RRB-
cord-318495-1w74wf02	131	46	[	[	-LRB-
cord-318495-1w74wf02	131	47	78	78	CD
cord-318495-1w74wf02	131	48	]	]	-RRB-
cord-318495-1w74wf02	131	49	[	[	-LRB-
cord-318495-1w74wf02	131	50	79	79	CD
cord-318495-1w74wf02	131	51	]	]	-RRB-
cord-318495-1w74wf02	132	1	[	[	-LRB-
cord-318495-1w74wf02	132	2	80	80	CD
cord-318495-1w74wf02	132	3	]	]	-RRB-
cord-318495-1w74wf02	133	1	[	[	-LRB-
cord-318495-1w74wf02	133	2	81	81	CD
cord-318495-1w74wf02	133	3	]	]	-RRB-
cord-318495-1w74wf02	133	4	[	[	-LRB-
cord-318495-1w74wf02	133	5	82	82	CD
cord-318495-1w74wf02	133	6	]	]	-RRB-
cord-318495-1w74wf02	133	7	.	.	.
cord-318495-1w74wf02	134	1	DVGs	dvg	NNS
cord-318495-1w74wf02	134	2	accumulate	accumulate	VBP
cord-318495-1w74wf02	134	3	at	at	IN
cord-318495-1w74wf02	134	4	higher	high	JJR
cord-318495-1w74wf02	134	5	rates	rate	NNS
cord-318495-1w74wf02	134	6	than	than	IN
cord-318495-1w74wf02	134	7	full	full	JJ
cord-318495-1w74wf02	134	8	-	-	HYPH
cord-318495-1w74wf02	134	9	length	length	NN
cord-318495-1w74wf02	134	10	viral	viral	JJ
cord-318495-1w74wf02	134	11	genomes	genome	NNS
cord-318495-1w74wf02	134	12	in	in	IN
cord-318495-1w74wf02	134	13	co	co	JJ
cord-318495-1w74wf02	134	14	-	-	JJ
cord-318495-1w74wf02	134	15	infected	infected	JJ
cord-318495-1w74wf02	134	16	cells	cell	NNS
cord-318495-1w74wf02	134	17	due	due	IN
cord-318495-1w74wf02	134	18	to	to	IN
cord-318495-1w74wf02	134	19	their	-PRON-	PRP$
cord-318495-1w74wf02	134	20	shortened	shorten	VBN
cord-318495-1w74wf02	134	21	length	length	NN
cord-318495-1w74wf02	134	22	and	and	CC
cord-318495-1w74wf02	134	23	,	,	,
cord-318495-1w74wf02	134	24	in	in	IN
cord-318495-1w74wf02	134	25	the	the	DT
cord-318495-1w74wf02	134	26	case	case	NN
cord-318495-1w74wf02	134	27	of	of	IN
cord-318495-1w74wf02	134	28	copy	copy	NN
cord-318495-1w74wf02	134	29	-	-	HYPH
cord-318495-1w74wf02	134	30	back	back	NN
cord-318495-1w74wf02	134	31	species	specie	NNS
cord-318495-1w74wf02	134	32	,	,	,
cord-318495-1w74wf02	134	33	their	-PRON-	PRP$
cord-318495-1w74wf02	134	34	highly	highly	RB
cord-318495-1w74wf02	134	35	efficient	efficient	JJ
cord-318495-1w74wf02	134	36	flanking	flank	VBG
cord-318495-1w74wf02	134	37	trailer	trailer	NN
cord-318495-1w74wf02	134	38	promoters	promoter	NNS
cord-318495-1w74wf02	134	39	83	83	CD
cord-318495-1w74wf02	134	40	,	,	,
cord-318495-1w74wf02	134	41	84	84	CD
cord-318495-1w74wf02	134	42	.	.	.
cord-318495-1w74wf02	135	1	A	a	DT
cord-318495-1w74wf02	135	2	predominant	predominant	JJ
cord-318495-1w74wf02	135	3	theory	theory	NN
cord-318495-1w74wf02	135	4	for	for	IN
cord-318495-1w74wf02	135	5	how	how	WRB
cord-318495-1w74wf02	135	6	DVGs	dvg	NNS
cord-318495-1w74wf02	135	7	interfere	interfere	VB
cord-318495-1w74wf02	135	8	with	with	IN
cord-318495-1w74wf02	135	9	the	the	DT
cord-318495-1w74wf02	135	10	replication	replication	NN
cord-318495-1w74wf02	135	11	of	of	IN
cord-318495-1w74wf02	135	12	standard	standard	JJ
cord-318495-1w74wf02	135	13	virus	virus	NN
cord-318495-1w74wf02	135	14	is	be	VBZ
cord-318495-1w74wf02	135	15	based	base	VBN
cord-318495-1w74wf02	135	16	on	on	IN
cord-318495-1w74wf02	135	17	the	the	DT
cord-318495-1w74wf02	135	18	observed	observed	JJ
cord-318495-1w74wf02	135	19	competition	competition	NN
cord-318495-1w74wf02	135	20	between	between	IN
cord-318495-1w74wf02	135	21	defective	defective	JJ
cord-318495-1w74wf02	135	22	and	and	CC
cord-318495-1w74wf02	135	23	full	full	JJ
cord-318495-1w74wf02	135	24	-	-	HYPH
cord-318495-1w74wf02	135	25	length	length	NN
cord-318495-1w74wf02	135	26	viral	viral	JJ
cord-318495-1w74wf02	135	27	genomes	genome	NNS
cord-318495-1w74wf02	135	28	for	for	IN
cord-318495-1w74wf02	135	29	viral	viral	JJ
cord-318495-1w74wf02	135	30	components	component	NNS
cord-318495-1w74wf02	135	31	needed	need	VBN
cord-318495-1w74wf02	135	32	for	for	IN
cord-318495-1w74wf02	135	33	replication	replication	NN
cord-318495-1w74wf02	135	34	(	(	-LRB-
cord-318495-1w74wf02	135	35	Fig	Fig	NNP
cord-318495-1w74wf02	135	36	.	.	.
cord-318495-1w74wf02	135	37	3b	3b	CD
cord-318495-1w74wf02	135	38	)	)	-RRB-
cord-318495-1w74wf02	135	39	.	.	.
cord-318495-1w74wf02	136	1	As	as	IN
cord-318495-1w74wf02	136	2	DVGs	dvg	NNS
cord-318495-1w74wf02	136	3	accumulate	accumulate	VBP
cord-318495-1w74wf02	136	4	to	to	IN
cord-318495-1w74wf02	136	5	high	high	JJ
cord-318495-1w74wf02	136	6	levels	level	NNS
cord-318495-1w74wf02	136	7	,	,	,
cord-318495-1w74wf02	136	8	it	-PRON-	PRP
cord-318495-1w74wf02	136	9	is	be	VBZ
cord-318495-1w74wf02	136	10	predicted	predict	VBN
cord-318495-1w74wf02	136	11	that	that	IN
cord-318495-1w74wf02	136	12	they	-PRON-	PRP
cord-318495-1w74wf02	136	13	can	can	MD
cord-318495-1w74wf02	136	14	directly	directly	RB
cord-318495-1w74wf02	136	15	interfere	interfere	VB
cord-318495-1w74wf02	136	16	with	with	IN
cord-318495-1w74wf02	136	17	helper	helper	NN
cord-318495-1w74wf02	136	18	virus	virus	NN
cord-318495-1w74wf02	136	19	replication	replication	NN
cord-318495-1w74wf02	136	20	by	by	IN
cord-318495-1w74wf02	136	21	monopolizing	monopolize	VBG
cord-318495-1w74wf02	136	22	the	the	DT
cord-318495-1w74wf02	136	23	viral	viral	JJ
cord-318495-1w74wf02	136	24	polymerase	polymerase	NN
cord-318495-1w74wf02	136	25	and/or	and/or	CC
cord-318495-1w74wf02	136	26	competing	compete	VBG
cord-318495-1w74wf02	136	27	for	for	IN
cord-318495-1w74wf02	136	28	structural	structural	JJ
cord-318495-1w74wf02	136	29	proteins	protein	NNS
cord-318495-1w74wf02	136	30	84	84	CD
cord-318495-1w74wf02	136	31	,	,	,
cord-318495-1w74wf02	136	32	85	85	CD
cord-318495-1w74wf02	136	33	.	.	.
cord-318495-1w74wf02	137	1	It	-PRON-	PRP
cord-318495-1w74wf02	137	2	should	should	MD
cord-318495-1w74wf02	137	3	be	be	VB
cord-318495-1w74wf02	137	4	noted	note	VBN
cord-318495-1w74wf02	137	5	that	that	IN
cord-318495-1w74wf02	137	6	while	while	IN
cord-318495-1w74wf02	137	7	most	most	JJS
cord-318495-1w74wf02	137	8	evidence	evidence	NN
cord-318495-1w74wf02	137	9	supports	support	VBZ
cord-318495-1w74wf02	137	10	the	the	DT
cord-318495-1w74wf02	137	11	notion	notion	NN
cord-318495-1w74wf02	137	12	that	that	IN
cord-318495-1w74wf02	137	13	the	the	DT
cord-318495-1w74wf02	137	14	shortest	short	JJS
cord-318495-1w74wf02	137	15	DVGs	dvg	NNS
cord-318495-1w74wf02	137	16	with	with	IN
cord-318495-1w74wf02	137	17	largest	large	JJS
cord-318495-1w74wf02	137	18	deletions	deletion	NNS
cord-318495-1w74wf02	137	19	are	be	VBP
cord-318495-1w74wf02	137	20	best	best	RB
cord-318495-1w74wf02	137	21	able	able	JJ
cord-318495-1w74wf02	137	22	to	to	TO
cord-318495-1w74wf02	137	23	outcompete	outcompete	VB
cord-318495-1w74wf02	137	24	full	full	JJ
cord-318495-1w74wf02	137	25	-	-	HYPH
cord-318495-1w74wf02	137	26	length	length	NN
cord-318495-1w74wf02	137	27	virus	virus	NN
cord-318495-1w74wf02	137	28	because	because	IN
cord-318495-1w74wf02	137	29	their	-PRON-	PRP$
cord-318495-1w74wf02	137	30	much	much	RB
cord-318495-1w74wf02	137	31	smaller	small	JJR
cord-318495-1w74wf02	137	32	size	size	NN
cord-318495-1w74wf02	137	33	can	can	MD
cord-318495-1w74wf02	137	34	be	be	VB
cord-318495-1w74wf02	137	35	more	more	RBR
cord-318495-1w74wf02	137	36	rapidly	rapidly	RB
cord-318495-1w74wf02	137	37	replicated	replicate	VBN
cord-318495-1w74wf02	137	38	,	,	,
cord-318495-1w74wf02	137	39	most	most	JJS
cord-318495-1w74wf02	137	40	of	of	IN
cord-318495-1w74wf02	137	41	these	these	DT
cord-318495-1w74wf02	137	42	studies	study	NNS
cord-318495-1w74wf02	137	43	consist	consist	VBP
cord-318495-1w74wf02	137	44	of	of	IN
cord-318495-1w74wf02	137	45	high	high	JJ
cord-318495-1w74wf02	137	46	MOI	MOI	NNP
cord-318495-1w74wf02	137	47	cell	cell	NN
cord-318495-1w74wf02	137	48	culture	culture	NN
cord-318495-1w74wf02	137	49	conditions	condition	NNS
cord-318495-1w74wf02	137	50	which	which	WDT
cord-318495-1w74wf02	137	51	favour	favour	VBP
cord-318495-1w74wf02	137	52	competition	competition	NN
cord-318495-1w74wf02	137	53	dynamics	dynamic	NNS
cord-318495-1w74wf02	137	54	based	base	VBN
cord-318495-1w74wf02	137	55	on	on	IN
cord-318495-1w74wf02	137	56	replication	replication	NN
cord-318495-1w74wf02	137	57	kinetics	kinetic	NNS
cord-318495-1w74wf02	137	58	.	.	.
cord-318495-1w74wf02	138	1	The	the	DT
cord-318495-1w74wf02	138	2	question	question	NN
cord-318495-1w74wf02	138	3	arises	arise	VBZ
cord-318495-1w74wf02	138	4	as	as	IN
cord-318495-1w74wf02	138	5	to	to	IN
cord-318495-1w74wf02	138	6	whether	whether	IN
cord-318495-1w74wf02	138	7	a	a	DT
cord-318495-1w74wf02	138	8	longer	long	JJR
cord-318495-1w74wf02	138	9	deletion	deletion	NN
cord-318495-1w74wf02	138	10	DVG	DVG	NNP
cord-318495-1w74wf02	138	11	that	that	WDT
cord-318495-1w74wf02	138	12	retains	retain	VBZ
cord-318495-1w74wf02	138	13	more	more	JJR
cord-318495-1w74wf02	138	14	coding	coding	NN
cord-318495-1w74wf02	138	15	sequence	sequence	NN
cord-318495-1w74wf02	138	16	,	,	,
cord-318495-1w74wf02	138	17	yet	yet	CC
cord-318495-1w74wf02	138	18	contains	contain	VBZ
cord-318495-1w74wf02	138	19	mutated	mutate	VBN
cord-318495-1w74wf02	138	20	proteins	protein	NNS
cord-318495-1w74wf02	138	21	(	(	-LRB-
cord-318495-1w74wf02	138	22	presumably	presumably	RB
cord-318495-1w74wf02	138	23	replicating	replicate	VBG
cord-318495-1w74wf02	138	24	faster	fast	RBR
cord-318495-1w74wf02	138	25	than	than	IN
cord-318495-1w74wf02	138	26	full	full	JJ
cord-318495-1w74wf02	138	27	-	-	HYPH
cord-318495-1w74wf02	138	28	length	length	NN
cord-318495-1w74wf02	138	29	genomes	genome	NNS
cord-318495-1w74wf02	138	30	,	,	,
cord-318495-1w74wf02	138	31	yet	yet	CC
cord-318495-1w74wf02	138	32	slower	slow	JJR
cord-318495-1w74wf02	138	33	than	than	IN
cord-318495-1w74wf02	138	34	the	the	DT
cord-318495-1w74wf02	138	35	shortest	short	JJS
cord-318495-1w74wf02	138	36	DVGs	dvg	NNS
cord-318495-1w74wf02	138	37	)	)	-RRB-
cord-318495-1w74wf02	138	38	,	,	,
cord-318495-1w74wf02	138	39	could	could	MD
cord-318495-1w74wf02	138	40	be	be	VB
cord-318495-1w74wf02	138	41	a	a	DT
cord-318495-1w74wf02	138	42	better	well	JJR
cord-318495-1w74wf02	138	43	competitor	competitor	NN
cord-318495-1w74wf02	138	44	of	of	IN
cord-318495-1w74wf02	138	45	wild	wild	JJ
cord-318495-1w74wf02	138	46	-	-	HYPH
cord-318495-1w74wf02	138	47	type	type	NN
cord-318495-1w74wf02	138	48	virus	virus	NN
cord-318495-1w74wf02	138	49	in	in	IN
cord-318495-1w74wf02	138	50	certain	certain	JJ
cord-318495-1w74wf02	138	51	conditions	condition	NNS
cord-318495-1w74wf02	138	52	because	because	IN
cord-318495-1w74wf02	138	53	it	-PRON-	PRP
cord-318495-1w74wf02	138	54	additionally	additionally	RB
cord-318495-1w74wf02	138	55	expresses	express	VBZ
cord-318495-1w74wf02	138	56	defective	defective	JJ
cord-318495-1w74wf02	138	57	proteins	protein	NNS
cord-318495-1w74wf02	138	58	that	that	WDT
cord-318495-1w74wf02	138	59	,	,	,
cord-318495-1w74wf02	138	60	in	in	IN
cord-318495-1w74wf02	138	61	turn	turn	NN
cord-318495-1w74wf02	138	62	,	,	,
cord-318495-1w74wf02	138	63	interfere	interfere	VB
cord-318495-1w74wf02	138	64	with	with	IN
cord-318495-1w74wf02	138	65	wild	wild	JJ
cord-318495-1w74wf02	138	66	-	-	HYPH
cord-318495-1w74wf02	138	67	type	type	NN
cord-318495-1w74wf02	138	68	proteins	protein	NNS
cord-318495-1w74wf02	138	69	(	(	-LRB-
cord-318495-1w74wf02	138	70	for	for	IN
cord-318495-1w74wf02	138	71	example	example	NN
cord-318495-1w74wf02	138	72	,	,	,
cord-318495-1w74wf02	138	73	in	in	IN
cord-318495-1w74wf02	138	74	multi	multi	JJ
cord-318495-1w74wf02	138	75	-	-	JJ
cord-318495-1w74wf02	138	76	component	component	JJ
cord-318495-1w74wf02	138	77	structures	structure	NNS
cord-318495-1w74wf02	138	78	such	such	JJ
cord-318495-1w74wf02	138	79	as	as	IN
cord-318495-1w74wf02	138	80	capsids	capsid	NNS
cord-318495-1w74wf02	138	81	or	or	CC
cord-318495-1w74wf02	138	82	replicases	replicase	NNS
cord-318495-1w74wf02	138	83	)	)	-RRB-
cord-318495-1w74wf02	138	84	.	.	.
cord-318495-1w74wf02	139	1	Furthermore	furthermore	RB
cord-318495-1w74wf02	139	2	,	,	,
cord-318495-1w74wf02	139	3	recent	recent	JJ
cord-318495-1w74wf02	139	4	studies	study	NNS
cord-318495-1w74wf02	139	5	have	have	VBP
cord-318495-1w74wf02	139	6	demonstrated	demonstrate	VBN
cord-318495-1w74wf02	139	7	that	that	IN
cord-318495-1w74wf02	139	8	DVGs	dvg	NNS
cord-318495-1w74wf02	139	9	and	and	CC
cord-318495-1w74wf02	139	10	full	full	JJ
cord-318495-1w74wf02	139	11	-	-	HYPH
cord-318495-1w74wf02	139	12	length	length	NN
cord-318495-1w74wf02	139	13	viral	viral	JJ
cord-318495-1w74wf02	139	14	genomes	genome	NNS
cord-318495-1w74wf02	139	15	dominate	dominate	VBP
cord-318495-1w74wf02	139	16	in	in	IN
cord-318495-1w74wf02	139	17	different	different	JJ
cord-318495-1w74wf02	139	18	cells	cell	NNS
cord-318495-1w74wf02	139	19	during	during	IN
cord-318495-1w74wf02	139	20	infection	infection	NN
cord-318495-1w74wf02	139	21	,	,	,
cord-318495-1w74wf02	139	22	DIPs	dip	NNS
cord-318495-1w74wf02	139	23	.	.	.
cord-318495-1w74wf02	140	1	Defective	defective	JJ
cord-318495-1w74wf02	140	2	interfering	interfere	VBG
cord-318495-1w74wf02	140	3	particles	particle	NNS
cord-318495-1w74wf02	140	4	.	.	.
cord-318495-1w74wf02	141	1	Viral	viral	JJ
cord-318495-1w74wf02	141	2	particles	particle	NNS
cord-318495-1w74wf02	141	3	containing	contain	VBG
cord-318495-1w74wf02	141	4	a	a	DT
cord-318495-1w74wf02	141	5	fraction	fraction	NN
cord-318495-1w74wf02	141	6	of	of	IN
cord-318495-1w74wf02	141	7	the	the	DT
cord-318495-1w74wf02	141	8	viral	viral	JJ
cord-318495-1w74wf02	141	9	genome	genome	NN
cord-318495-1w74wf02	141	10	able	able	JJ
cord-318495-1w74wf02	141	11	to	to	TO
cord-318495-1w74wf02	141	12	replicate	replicate	VB
cord-318495-1w74wf02	141	13	only	only	RB
cord-318495-1w74wf02	141	14	in	in	IN
cord-318495-1w74wf02	141	15	the	the	DT
cord-318495-1w74wf02	141	16	presence	presence	NN
cord-318495-1w74wf02	141	17	of	of	IN
cord-318495-1w74wf02	141	18	helper	helper	NN
cord-318495-1w74wf02	141	19	virus	virus	NN
cord-318495-1w74wf02	141	20	and	and	CC
cord-318495-1w74wf02	141	21	interfere	interfere	VB
cord-318495-1w74wf02	141	22	with	with	IN
cord-318495-1w74wf02	141	23	the	the	DT
cord-318495-1w74wf02	141	24	intracellular	intracellular	JJ
cord-318495-1w74wf02	141	25	replication	replication	NN
cord-318495-1w74wf02	141	26	of	of	IN
cord-318495-1w74wf02	141	27	non	non	JJ
cord-318495-1w74wf02	141	28	-	-	JJ
cord-318495-1w74wf02	141	29	defective	defective	JJ
cord-318495-1w74wf02	141	30	homologous	homologous	JJ
cord-318495-1w74wf02	141	31	virus	virus	NN
cord-318495-1w74wf02	141	32	.	.	.
cord-318495-1w74wf02	142	1	DVGs	dvg	NNS
cord-318495-1w74wf02	142	2	.	.	.
cord-318495-1w74wf02	143	1	Defective	defective	JJ
cord-318495-1w74wf02	143	2	viral	viral	JJ
cord-318495-1w74wf02	143	3	genomes	genome	NNS
cord-318495-1w74wf02	143	4	.	.	.
cord-318495-1w74wf02	144	1	Viral	viral	JJ
cord-318495-1w74wf02	144	2	genomes	genome	NNS
cord-318495-1w74wf02	144	3	with	with	IN
cord-318495-1w74wf02	144	4	defective	defective	JJ
cord-318495-1w74wf02	144	5	ability	ability	NN
cord-318495-1w74wf02	144	6	to	to	TO
cord-318495-1w74wf02	144	7	replicate	replicate	VB
cord-318495-1w74wf02	144	8	in	in	IN
cord-318495-1w74wf02	144	9	the	the	DT
cord-318495-1w74wf02	144	10	absence	absence	NN
cord-318495-1w74wf02	144	11	of	of	IN
cord-318495-1w74wf02	144	12	a	a	DT
cord-318495-1w74wf02	144	13	co	co	NN
cord-318495-1w74wf02	144	14	-	-	JJ
cord-318495-1w74wf02	144	15	infecting	infect	VBG
cord-318495-1w74wf02	144	16	standard	standard	JJ
cord-318495-1w74wf02	144	17	virus	virus	NN
cord-318495-1w74wf02	144	18	.	.	.
cord-318495-1w74wf02	145	1	Viral	viral	JJ
cord-318495-1w74wf02	145	2	genomes	genome	NNS
cord-318495-1w74wf02	145	3	can	can	MD
cord-318495-1w74wf02	145	4	become	become	VB
cord-318495-1w74wf02	145	5	defective	defective	JJ
cord-318495-1w74wf02	145	6	due	due	IN
cord-318495-1w74wf02	145	7	to	to	IN
cord-318495-1w74wf02	145	8	mutations	mutation	NNS
cord-318495-1w74wf02	145	9	,	,	,
cord-318495-1w74wf02	145	10	deletions	deletion	NNS
cord-318495-1w74wf02	145	11	or	or	CC
cord-318495-1w74wf02	145	12	a	a	DT
cord-318495-1w74wf02	145	13	variety	variety	NN
cord-318495-1w74wf02	145	14	of	of	IN
cord-318495-1w74wf02	145	15	gene	gene	NN
cord-318495-1w74wf02	145	16	rearrangements	rearrangement	NNS
cord-318495-1w74wf02	145	17	.	.	.
cord-318495-1w74wf02	146	1	RdRP	RdRP	NNP
cord-318495-1w74wf02	146	2	.	.	.
cord-318495-1w74wf02	147	1	RNA	RNA	NNP
cord-318495-1w74wf02	147	2	-	-	HYPH
cord-318495-1w74wf02	147	3	dependent	dependent	JJ
cord-318495-1w74wf02	147	4	RNA	RNA	NNP
cord-318495-1w74wf02	147	5	polymerase	polymerase	NN
cord-318495-1w74wf02	147	6	.	.	.
cord-318495-1w74wf02	148	1	Viral	viral	JJ
cord-318495-1w74wf02	148	2	enzyme	enzyme	NN
cord-318495-1w74wf02	148	3	that	that	WDT
cord-318495-1w74wf02	148	4	copies	copy	VBZ
cord-318495-1w74wf02	148	5	the	the	DT
cord-318495-1w74wf02	148	6	viral	viral	JJ
cord-318495-1w74wf02	148	7	RNA	RNA	NNP
cord-318495-1w74wf02	148	8	during	during	IN
cord-318495-1w74wf02	148	9	viral	viral	JJ
cord-318495-1w74wf02	148	10	replication	replication	NN
cord-318495-1w74wf02	148	11	.	.	.
cord-318495-1w74wf02	149	1	TIPs	tip	NNS
cord-318495-1w74wf02	149	2	.	.	.
cord-318495-1w74wf02	150	1	Therapeutic	therapeutic	JJ
cord-318495-1w74wf02	150	2	interfering	interfere	VBG
cord-318495-1w74wf02	150	3	particles	particle	NNS
cord-318495-1w74wf02	150	4	.	.	.
cord-318495-1w74wf02	151	1	Synthetic	synthetic	JJ
cord-318495-1w74wf02	151	2	DVGs	dvg	NNS
cord-318495-1w74wf02	151	3	with	with	IN
cord-318495-1w74wf02	151	4	strong	strong	JJ
cord-318495-1w74wf02	151	5	interfering	interfere	VBG
cord-318495-1w74wf02	151	6	activity	activity	NN
cord-318495-1w74wf02	151	7	proposed	propose	VBN
cord-318495-1w74wf02	151	8	as	as	IN
cord-318495-1w74wf02	151	9	therapeutics	therapeutic	NNS
cord-318495-1w74wf02	151	10	to	to	TO
cord-318495-1w74wf02	151	11	outcompete	outcompete	VB
cord-318495-1w74wf02	151	12	standard	standard	JJ
cord-318495-1w74wf02	151	13	viruses	virus	NNS
cord-318495-1w74wf02	151	14	.	.	.
cord-318495-1w74wf02	152	1	conferring	confer	VBG
cord-318495-1w74wf02	152	2	distinct	distinct	JJ
cord-318495-1w74wf02	152	3	functions	function	NNS
cord-318495-1w74wf02	152	4	to	to	IN
cord-318495-1w74wf02	152	5	different	different	JJ
cord-318495-1w74wf02	152	6	infected	infected	JJ
cord-318495-1w74wf02	152	7	cells	cell	NNS
cord-318495-1w74wf02	152	8	86	86	CD
cord-318495-1w74wf02	152	9	,	,	,
cord-318495-1w74wf02	152	10	87	87	CD
cord-318495-1w74wf02	152	11	.	.	.
cord-318495-1w74wf02	153	1	While	while	IN
cord-318495-1w74wf02	153	2	cells	cell	NNS
cord-318495-1w74wf02	153	3	dominated	dominate	VBN
cord-318495-1w74wf02	153	4	with	with	IN
cord-318495-1w74wf02	153	5	full	full	JJ
cord-318495-1w74wf02	153	6	-	-	HYPH
cord-318495-1w74wf02	153	7	length	length	NN
cord-318495-1w74wf02	153	8	viral	viral	JJ
cord-318495-1w74wf02	153	9	genomes	genome	NNS
cord-318495-1w74wf02	153	10	are	be	VBP
cord-318495-1w74wf02	153	11	the	the	DT
cord-318495-1w74wf02	153	12	predominant	predominant	JJ
cord-318495-1w74wf02	153	13	producers	producer	NNS
cord-318495-1w74wf02	153	14	of	of	IN
cord-318495-1w74wf02	153	15	viral	viral	JJ
cord-318495-1w74wf02	153	16	particles	particle	NNS
cord-318495-1w74wf02	153	17	containing	contain	VBG
cord-318495-1w74wf02	153	18	either	either	CC
cord-318495-1w74wf02	153	19	full	full	JJ
cord-318495-1w74wf02	153	20	-	-	HYPH
cord-318495-1w74wf02	153	21	length	length	NN
cord-318495-1w74wf02	153	22	or	or	CC
cord-318495-1w74wf02	153	23	defective	defective	JJ
cord-318495-1w74wf02	153	24	genomes	genome	NNS
cord-318495-1w74wf02	153	25	,	,	,
cord-318495-1w74wf02	153	26	cells	cell	NNS
cord-318495-1w74wf02	153	27	enriched	enrich	VBN
cord-318495-1w74wf02	153	28	in	in	IN
cord-318495-1w74wf02	153	29	DVGs	dvg	NNS
cord-318495-1w74wf02	153	30	do	do	VBP
cord-318495-1w74wf02	153	31	not	not	RB
cord-318495-1w74wf02	153	32	produce	produce	VB
cord-318495-1w74wf02	153	33	many	many	JJ
cord-318495-1w74wf02	153	34	particles	particle	NNS
cord-318495-1w74wf02	153	35	of	of	IN
cord-318495-1w74wf02	153	36	any	any	DT
cord-318495-1w74wf02	153	37	species	species	NN
cord-318495-1w74wf02	153	38	86	86	CD
cord-318495-1w74wf02	153	39	.	.	.
cord-318495-1w74wf02	154	1	These	these	DT
cord-318495-1w74wf02	154	2	data	datum	NNS
cord-318495-1w74wf02	154	3	highlight	highlight	VBP
cord-318495-1w74wf02	154	4	the	the	DT
cord-318495-1w74wf02	154	5	need	need	NN
cord-318495-1w74wf02	154	6	to	to	TO
cord-318495-1w74wf02	154	7	consider	consider	VB
cord-318495-1w74wf02	154	8	the	the	DT
cord-318495-1w74wf02	154	9	single	single	JJ
cord-318495-1w74wf02	154	10	cell	cell	NN
cord-318495-1w74wf02	154	11	versus	versus	IN
cord-318495-1w74wf02	154	12	population	population	NN
cord-318495-1w74wf02	154	13	level	level	NN
cord-318495-1w74wf02	154	14	impacts	impact	NNS
cord-318495-1w74wf02	154	15	of	of	IN
cord-318495-1w74wf02	154	16	DVGs	dvg	NNS
cord-318495-1w74wf02	154	17	during	during	IN
cord-318495-1w74wf02	154	18	interference	interference	NN
cord-318495-1w74wf02	154	19	.	.	.
cord-318495-1w74wf02	155	1	Triggers	trigger	NNS
cord-318495-1w74wf02	155	2	of	of	IN
cord-318495-1w74wf02	155	3	antiviral	antiviral	JJ
cord-318495-1w74wf02	155	4	immunity	immunity	NN
cord-318495-1w74wf02	155	5	.	.	.
cord-318495-1w74wf02	156	1	DVGs	dvg	NNS
cord-318495-1w74wf02	156	2	,	,	,
cord-318495-1w74wf02	156	3	especially	especially	RB
cord-318495-1w74wf02	156	4	those	those	DT
cord-318495-1w74wf02	156	5	of	of	IN
cord-318495-1w74wf02	156	6	the	the	DT
cord-318495-1w74wf02	156	7	copy	copy	NN
cord-318495-1w74wf02	156	8	-	-	HYPH
cord-318495-1w74wf02	156	9	back	back	NN
cord-318495-1w74wf02	156	10	type	type	NN
cord-318495-1w74wf02	156	11	,	,	,
cord-318495-1w74wf02	156	12	strongly	strongly	RB
cord-318495-1w74wf02	156	13	induce	induce	VB
cord-318495-1w74wf02	156	14	the	the	DT
cord-318495-1w74wf02	156	15	expression	expression	NN
cord-318495-1w74wf02	156	16	of	of	IN
cord-318495-1w74wf02	156	17	type	type	NN
cord-318495-1w74wf02	156	18	I	-PRON-	PRP
cord-318495-1w74wf02	156	19	and	and	CC
cord-318495-1w74wf02	156	20	III	III	NNP
cord-318495-1w74wf02	156	21	IFNs	ifn	NNS
cord-318495-1w74wf02	156	22	,	,	,
cord-318495-1w74wf02	156	23	tumour	tumour	NN
cord-318495-1w74wf02	156	24	necrosis	necrosis	NN
cord-318495-1w74wf02	156	25	factor	factor	NN
cord-318495-1w74wf02	156	26	(	(	-LRB-
cord-318495-1w74wf02	156	27	TNF	TNF	NNP
cord-318495-1w74wf02	156	28	)	)	-RRB-
cord-318495-1w74wf02	156	29	,	,	,
cord-318495-1w74wf02	156	30	interleukin	interleukin	FW
cord-318495-1w74wf02	156	31	(	(	-LRB-
cord-318495-1w74wf02	156	32	IL)-6	IL)-6	NNP
cord-318495-1w74wf02	156	33	,	,	,
cord-318495-1w74wf02	156	34	IL-1β	IL-1β	NNP
cord-318495-1w74wf02	156	35	and	and	CC
cord-318495-1w74wf02	156	36	other	other	JJ
cord-318495-1w74wf02	156	37	pro	pro	JJ
cord-318495-1w74wf02	156	38	-	-	JJ
cord-318495-1w74wf02	156	39	inflammatory	inflammatory	JJ
cord-318495-1w74wf02	156	40	cytokines	cytokine	NNS
cord-318495-1w74wf02	156	41	,	,	,
cord-318495-1w74wf02	156	42	and	and	CC
cord-318495-1w74wf02	156	43	are	be	VBP
cord-318495-1w74wf02	156	44	the	the	DT
cord-318495-1w74wf02	156	45	primary	primary	JJ
cord-318495-1w74wf02	156	46	stimuli	stimulus	NNS
cord-318495-1w74wf02	156	47	of	of	IN
cord-318495-1w74wf02	156	48	antiviral	antiviral	JJ
cord-318495-1w74wf02	156	49	immunity	immunity	NN
cord-318495-1w74wf02	156	50	in	in	IN
cord-318495-1w74wf02	156	51	many	many	JJ
cord-318495-1w74wf02	156	52	infections	infection	NNS
cord-318495-1w74wf02	156	53	[	[	-LRB-
cord-318495-1w74wf02	156	54	6	6	CD
cord-318495-1w74wf02	156	55	]	]	-RRB-
cord-318495-1w74wf02	156	56	[	[	-LRB-
cord-318495-1w74wf02	156	57	7	7	CD
cord-318495-1w74wf02	156	58	]	]	-RRB-
cord-318495-1w74wf02	156	59	[	[	-LRB-
cord-318495-1w74wf02	156	60	8	8	CD
cord-318495-1w74wf02	156	61	]	]	-RRB-
cord-318495-1w74wf02	156	62	52	52	CD
cord-318495-1w74wf02	156	63	,	,	,
cord-318495-1w74wf02	156	64	54	54	CD
cord-318495-1w74wf02	156	65	,	,	,
cord-318495-1w74wf02	156	66	55	55	CD
cord-318495-1w74wf02	156	67	,	,	,
cord-318495-1w74wf02	156	68	[	[	-LRB-
cord-318495-1w74wf02	156	69	88	88	CD
cord-318495-1w74wf02	156	70	]	]	-RRB-
cord-318495-1w74wf02	156	71	[	[	-LRB-
cord-318495-1w74wf02	156	72	89	89	CD
cord-318495-1w74wf02	156	73	]	]	-RRB-
cord-318495-1w74wf02	156	74	[	[	-LRB-
cord-318495-1w74wf02	156	75	90	90	CD
cord-318495-1w74wf02	156	76	]	]	-RRB-
cord-318495-1w74wf02	156	77	(	(	-LRB-
cord-318495-1w74wf02	156	78	Fig	Fig	NNP
cord-318495-1w74wf02	156	79	.	.	.
cord-318495-1w74wf02	156	80	3c	3c	NNP
cord-318495-1w74wf02	156	81	)	)	-RRB-
cord-318495-1w74wf02	156	82	.	.	.
cord-318495-1w74wf02	157	1	In	in	IN
cord-318495-1w74wf02	157	2	addition	addition	NN
cord-318495-1w74wf02	157	3	,	,	,
cord-318495-1w74wf02	157	4	DVG	DVG	NNP
cord-318495-1w74wf02	157	5	stimulation	stimulation	NN
cord-318495-1w74wf02	157	6	optimizes	optimize	VBZ
cord-318495-1w74wf02	157	7	the	the	DT
cord-318495-1w74wf02	157	8	antigen	antigen	NN
cord-318495-1w74wf02	157	9	presentation	presentation	NN
cord-318495-1w74wf02	157	10	capacity	capacity	NN
cord-318495-1w74wf02	157	11	of	of	IN
cord-318495-1w74wf02	157	12	antigen	antigen	NN
cord-318495-1w74wf02	157	13	-	-	HYPH
cord-318495-1w74wf02	157	14	presenting	present	VBG
cord-318495-1w74wf02	157	15	cells	cell	NNS
cord-318495-1w74wf02	157	16	91	91	CD
cord-318495-1w74wf02	157	17	,	,	,
cord-318495-1w74wf02	157	18	92	92	CD
cord-318495-1w74wf02	157	19	.	.	.
cord-318495-1w74wf02	158	1	Accumulating	accumulate	VBG
cord-318495-1w74wf02	158	2	evidence	evidence	NN
cord-318495-1w74wf02	158	3	indicates	indicate	VBZ
cord-318495-1w74wf02	158	4	that	that	IN
cord-318495-1w74wf02	158	5	the	the	DT
cord-318495-1w74wf02	158	6	immunostimulatory	immunostimulatory	NNP
cord-318495-1w74wf02	158	7	activity	activity	NN
cord-318495-1w74wf02	158	8	of	of	IN
cord-318495-1w74wf02	158	9	DVGs	dvg	NNS
cord-318495-1w74wf02	158	10	is	be	VBZ
cord-318495-1w74wf02	158	11	maintained	maintain	VBN
cord-318495-1w74wf02	158	12	in	in	IN
cord-318495-1w74wf02	158	13	vivo	vivo	NN
cord-318495-1w74wf02	158	14	and	and	CC
cord-318495-1w74wf02	158	15	during	during	IN
cord-318495-1w74wf02	158	16	natural	natural	JJ
cord-318495-1w74wf02	158	17	infections	infection	NNS
cord-318495-1w74wf02	158	18	in	in	IN
cord-318495-1w74wf02	158	19	humans	human	NNS
cord-318495-1w74wf02	158	20	.	.	.
cord-318495-1w74wf02	159	1	Increased	increase	VBN
cord-318495-1w74wf02	159	2	survival	survival	NN
cord-318495-1w74wf02	159	3	of	of	IN
cord-318495-1w74wf02	159	4	infected	infected	JJ
cord-318495-1w74wf02	159	5	mice	mouse	NNS
cord-318495-1w74wf02	159	6	in	in	IN
cord-318495-1w74wf02	159	7	infections	infection	NNS
cord-318495-1w74wf02	159	8	containing	contain	VBG
cord-318495-1w74wf02	159	9	DVGs	dvg	NNS
cord-318495-1w74wf02	159	10	have	have	VBP
cord-318495-1w74wf02	159	11	been	be	VBN
cord-318495-1w74wf02	159	12	reported	report	VBN
cord-318495-1w74wf02	159	13	for	for	IN
cord-318495-1w74wf02	159	14	multiple	multiple	JJ
cord-318495-1w74wf02	159	15	viruses	virus	NNS
cord-318495-1w74wf02	159	16	5	5	CD
cord-318495-1w74wf02	159	17	,	,	,
cord-318495-1w74wf02	159	18	19	19	CD
cord-318495-1w74wf02	159	19	,	,	,
cord-318495-1w74wf02	159	20	93	93	CD
cord-318495-1w74wf02	159	21	.	.	.
cord-318495-1w74wf02	160	1	In	in	IN
cord-318495-1w74wf02	160	2	mice	mouse	NNS
cord-318495-1w74wf02	160	3	infected	infect	VBN
cord-318495-1w74wf02	160	4	with	with	IN
cord-318495-1w74wf02	160	5	the	the	DT
cord-318495-1w74wf02	160	6	respiratory	respiratory	JJ
cord-318495-1w74wf02	160	7	viruses	virus	NNS
cord-318495-1w74wf02	160	8	SeV	sev	NN
cord-318495-1w74wf02	160	9	,	,	,
cord-318495-1w74wf02	160	10	influenza	influenza	NN
cord-318495-1w74wf02	160	11	or	or	CC
cord-318495-1w74wf02	160	12	RSV	RSV	NNP
cord-318495-1w74wf02	160	13	,	,	,
cord-318495-1w74wf02	160	14	IFNs	ifn	NNS
cord-318495-1w74wf02	160	15	and	and	CC
cord-318495-1w74wf02	160	16	pro	pro	JJ
cord-318495-1w74wf02	160	17	-	-	JJ
cord-318495-1w74wf02	160	18	inflammatory	inflammatory	JJ
cord-318495-1w74wf02	160	19	cytokines	cytokine	NNS
cord-318495-1w74wf02	160	20	are	be	VBP
cord-318495-1w74wf02	160	21	strongly	strongly	RB
cord-318495-1w74wf02	160	22	induced	induce	VBN
cord-318495-1w74wf02	160	23	only	only	RB
cord-318495-1w74wf02	160	24	after	after	IN
cord-318495-1w74wf02	160	25	DVGs	dvg	NNS
cord-318495-1w74wf02	160	26	have	have	VBP
cord-318495-1w74wf02	160	27	accumulated	accumulate	VBN
cord-318495-1w74wf02	160	28	to	to	IN
cord-318495-1w74wf02	160	29	detectable	detectable	JJ
cord-318495-1w74wf02	160	30	levels	level	NNS
cord-318495-1w74wf02	160	31	54	54	CD
cord-318495-1w74wf02	160	32	,	,	,
cord-318495-1w74wf02	160	33	55	55	CD
cord-318495-1w74wf02	160	34	.	.	.
cord-318495-1w74wf02	161	1	Detection	detection	NN
cord-318495-1w74wf02	161	2	of	of	IN
cord-318495-1w74wf02	161	3	DVGs	dvg	NNS
cord-318495-1w74wf02	161	4	in	in	IN
cord-318495-1w74wf02	161	5	respiratory	respiratory	JJ
cord-318495-1w74wf02	161	6	secretions	secretion	NNS
cord-318495-1w74wf02	161	7	of	of	IN
cord-318495-1w74wf02	161	8	children	child	NNS
cord-318495-1w74wf02	161	9	infected	infect	VBN
cord-318495-1w74wf02	161	10	with	with	IN
cord-318495-1w74wf02	161	11	RSV	RSV	NNP
cord-318495-1w74wf02	161	12	correlates	correlate	VBZ
cord-318495-1w74wf02	161	13	with	with	IN
cord-318495-1w74wf02	161	14	expression	expression	NN
cord-318495-1w74wf02	161	15	of	of	IN
cord-318495-1w74wf02	161	16	antiviral	antiviral	JJ
cord-318495-1w74wf02	161	17	genes	gene	NNS
cord-318495-1w74wf02	161	18	55	55	CD
cord-318495-1w74wf02	161	19	,	,	,
cord-318495-1w74wf02	161	20	and	and	CC
cord-318495-1w74wf02	161	21	highly	highly	RB
cord-318495-1w74wf02	161	22	pathogenic	pathogenic	JJ
cord-318495-1w74wf02	161	23	influenza	influenza	NN
cord-318495-1w74wf02	161	24	virus	virus	NN
cord-318495-1w74wf02	162	1	isolates	isolate	NNS
cord-318495-1w74wf02	162	2	that	that	WDT
cord-318495-1w74wf02	162	3	fail	fail	VBP
cord-318495-1w74wf02	162	4	to	to	TO
cord-318495-1w74wf02	162	5	induce	induce	VB
cord-318495-1w74wf02	162	6	potent	potent	JJ
cord-318495-1w74wf02	162	7	antiviral	antiviral	JJ
cord-318495-1w74wf02	162	8	responses	response	NNS
cord-318495-1w74wf02	162	9	in	in	IN
cord-318495-1w74wf02	162	10	humans	human	NNS
cord-318495-1w74wf02	162	11	have	have	VBP
cord-318495-1w74wf02	162	12	an	an	DT
cord-318495-1w74wf02	162	13	impaired	impaired	JJ
cord-318495-1w74wf02	162	14	ability	ability	NN
cord-318495-1w74wf02	162	15	to	to	TO
cord-318495-1w74wf02	162	16	generate	generate	VB
cord-318495-1w74wf02	162	17	DVGs	dvg	NNS
cord-318495-1w74wf02	162	18	62	62	CD
cord-318495-1w74wf02	162	19	.	.	.
cord-318495-1w74wf02	163	1	Immunostimulatory	Immunostimulatory	NNP
cord-318495-1w74wf02	163	2	DVGs	dvg	NNS
cord-318495-1w74wf02	163	3	can	can	MD
cord-318495-1w74wf02	163	4	be	be	VB
cord-318495-1w74wf02	163	5	recognized	recognize	VBN
cord-318495-1w74wf02	163	6	by	by	IN
cord-318495-1w74wf02	163	7	pattern	pattern	NN
cord-318495-1w74wf02	163	8	recognition	recognition	NN
cord-318495-1w74wf02	163	9	receptors	receptor	NNS
cord-318495-1w74wf02	163	10	(	(	-LRB-
cord-318495-1w74wf02	163	11	PRRs	PRRs	NNP
cord-318495-1w74wf02	163	12	)	)	-RRB-
cord-318495-1w74wf02	163	13	,	,	,
cord-318495-1w74wf02	163	14	including	include	VBG
cord-318495-1w74wf02	163	15	Toll	toll	NN
cord-318495-1w74wf02	163	16	-	-	HYPH
cord-318495-1w74wf02	163	17	like	like	JJ
cord-318495-1w74wf02	163	18	receptors	receptor	NNS
cord-318495-1w74wf02	163	19	(	(	-LRB-
cord-318495-1w74wf02	163	20	TLRs	TLRs	NNP
cord-318495-1w74wf02	163	21	)	)	-RRB-
cord-318495-1w74wf02	163	22	and	and	CC
cord-318495-1w74wf02	163	23	RIG	rig	NN
cord-318495-1w74wf02	163	24	-	-	HYPH
cord-318495-1w74wf02	163	25	I	i	NN
cord-318495-1w74wf02	163	26	-	-	HYPH
cord-318495-1w74wf02	163	27	like	like	JJ
cord-318495-1w74wf02	163	28	receptors	receptor	NNS
cord-318495-1w74wf02	163	29	(	(	-LRB-
cord-318495-1w74wf02	163	30	RLRs	rlr	NNS
cord-318495-1w74wf02	163	31	)	)	-RRB-
cord-318495-1w74wf02	163	32	.	.	.
cord-318495-1w74wf02	164	1	While	while	IN
cord-318495-1w74wf02	164	2	TLR	TLR	NNP
cord-318495-1w74wf02	164	3	signalling	signalling	NN
cord-318495-1w74wf02	164	4	is	be	VBZ
cord-318495-1w74wf02	164	5	not	not	RB
cord-318495-1w74wf02	164	6	essential	essential	JJ
cord-318495-1w74wf02	164	7	for	for	IN
cord-318495-1w74wf02	164	8	production	production	NN
cord-318495-1w74wf02	164	9	of	of	IN
cord-318495-1w74wf02	164	10	type	type	NN
cord-318495-1w74wf02	165	1	I	-PRON-	PRP
cord-318495-1w74wf02	165	2	IFNs	ifns	VBP
cord-318495-1w74wf02	165	3	in	in	IN
cord-318495-1w74wf02	165	4	vitro	vitro	FW
cord-318495-1w74wf02	165	5	in	in	IN
cord-318495-1w74wf02	165	6	response	response	NN
cord-318495-1w74wf02	165	7	to	to	IN
cord-318495-1w74wf02	165	8	DVGs	dvg	NNS
cord-318495-1w74wf02	165	9	,	,	,
cord-318495-1w74wf02	165	10	RLR	RLR	NNP
cord-318495-1w74wf02	165	11	signalling	signalling	NN
cord-318495-1w74wf02	165	12	is	be	VBZ
cord-318495-1w74wf02	165	13	required	require	VBN
cord-318495-1w74wf02	165	14	55	55	CD
cord-318495-1w74wf02	165	15	,	,	,
cord-318495-1w74wf02	165	16	88	88	CD
cord-318495-1w74wf02	165	17	,	,	,
cord-318495-1w74wf02	165	18	[	[	-LRB-
cord-318495-1w74wf02	165	19	94	94	CD
cord-318495-1w74wf02	165	20	]	]	-RRB-
cord-318495-1w74wf02	165	21	[	[	-LRB-
cord-318495-1w74wf02	165	22	95	95	CD
cord-318495-1w74wf02	165	23	]	]	-RRB-
cord-318495-1w74wf02	166	1	[	[	-LRB-
cord-318495-1w74wf02	166	2	96	96	CD
cord-318495-1w74wf02	166	3	]	]	-RRB-
cord-318495-1w74wf02	166	4	[	[	-LRB-
cord-318495-1w74wf02	166	5	97	97	CD
cord-318495-1w74wf02	166	6	]	]	-RRB-
cord-318495-1w74wf02	166	7	[	[	-LRB-
cord-318495-1w74wf02	166	8	98	98	CD
cord-318495-1w74wf02	166	9	]	]	-RRB-
cord-318495-1w74wf02	166	10	.	.	.
cord-318495-1w74wf02	167	1	SeV	SeV	NNP
cord-318495-1w74wf02	167	2	copy	copy	NN
cord-318495-1w74wf02	167	3	-	-	HYPH
cord-318495-1w74wf02	167	4	back	back	NN
cord-318495-1w74wf02	167	5	DVGs	dvg	NNS
cord-318495-1w74wf02	167	6	are	be	VBP
cord-318495-1w74wf02	167	7	stronger	strong	JJR
cord-318495-1w74wf02	167	8	immunostimulators	immunostimulator	NNS
cord-318495-1w74wf02	167	9	than	than	IN
cord-318495-1w74wf02	167	10	deletion	deletion	NN
cord-318495-1w74wf02	167	11	DVGs	dvg	NNS
cord-318495-1w74wf02	167	12	89	89	CD
cord-318495-1w74wf02	167	13	and	and	CC
cord-318495-1w74wf02	167	14	are	be	VBP
cord-318495-1w74wf02	167	15	among	among	IN
cord-318495-1w74wf02	167	16	the	the	DT
cord-318495-1w74wf02	167	17	strongest	strong	JJS
cord-318495-1w74wf02	167	18	known	know	VBN
cord-318495-1w74wf02	167	19	inducers	inducer	NNS
cord-318495-1w74wf02	167	20	of	of	IN
cord-318495-1w74wf02	167	21	the	the	DT
cord-318495-1w74wf02	167	22	antiviral	antiviral	JJ
cord-318495-1w74wf02	167	23	response	response	NN
cord-318495-1w74wf02	167	24	.	.	.
cord-318495-1w74wf02	168	1	Therefore	therefore	RB
cord-318495-1w74wf02	168	2	,	,	,
cord-318495-1w74wf02	168	3	much	much	JJ
cord-318495-1w74wf02	168	4	of	of	IN
cord-318495-1w74wf02	168	5	what	what	WP
cord-318495-1w74wf02	168	6	we	-PRON-	PRP
cord-318495-1w74wf02	168	7	know	know	VBP
cord-318495-1w74wf02	168	8	of	of	IN
cord-318495-1w74wf02	168	9	DVGs	dvg	NNS
cord-318495-1w74wf02	168	10	immunostimulatory	immunostimulatory	NNP
cord-318495-1w74wf02	168	11	activity	activity	NN
cord-318495-1w74wf02	168	12	is	be	VBZ
cord-318495-1w74wf02	168	13	based	base	VBN
cord-318495-1w74wf02	168	14	on	on	IN
cord-318495-1w74wf02	168	15	the	the	DT
cord-318495-1w74wf02	168	16	study	study	NN
cord-318495-1w74wf02	168	17	of	of	IN
cord-318495-1w74wf02	168	18	SeV	SeV	NNP
cord-318495-1w74wf02	168	19	copy	copy	NN
cord-318495-1w74wf02	168	20	-	-	HYPH
cord-318495-1w74wf02	168	21	back	back	NN
cord-318495-1w74wf02	168	22	DVGs	dvg	NNS
cord-318495-1w74wf02	168	23	.	.	.
cord-318495-1w74wf02	169	1	Copy	copy	NN
cord-318495-1w74wf02	169	2	-	-	HYPH
cord-318495-1w74wf02	169	3	back	back	NN
cord-318495-1w74wf02	169	4	DVG	DVG	NNP
cord-318495-1w74wf02	169	5	RNA	RNA	NNP
cord-318495-1w74wf02	169	6	binds	bind	VBZ
cord-318495-1w74wf02	169	7	RIG	rig	NN
cord-318495-1w74wf02	169	8	-	-	:
cord-318495-1w74wf02	169	9	I	I	NNP
cord-318495-1w74wf02	169	10	94,97,99	94,97,99	CD
cord-318495-1w74wf02	169	11	and	and	CC
cord-318495-1w74wf02	169	12	DVGs	dvg	NNS
cord-318495-1w74wf02	169	13	from	from	IN
cord-318495-1w74wf02	169	14	SeV	sev	NN
cord-318495-1w74wf02	169	15	,	,	,
cord-318495-1w74wf02	169	16	MeV	MeV	NNP
cord-318495-1w74wf02	169	17	and	and	CC
cord-318495-1w74wf02	169	18	RSV	RSV	NNP
cord-318495-1w74wf02	169	19	viruses	virus	NNS
cord-318495-1w74wf02	169	20	strongly	strongly	RB
cord-318495-1w74wf02	169	21	stimulate	stimulate	VBP
cord-318495-1w74wf02	169	22	RIG	rig	NN
cord-318495-1w74wf02	169	23	-	-	HYPH
cord-318495-1w74wf02	169	24	I	i	NN
cord-318495-1w74wf02	169	25	-	-	HYPH
cord-318495-1w74wf02	169	26	dependent	dependent	JJ
cord-318495-1w74wf02	169	27	signalling	signal	VBG
cord-318495-1w74wf02	169	28	55	55	CD
cord-318495-1w74wf02	169	29	,	,	,
cord-318495-1w74wf02	169	30	92	92	CD
cord-318495-1w74wf02	169	31	,	,	,
cord-318495-1w74wf02	169	32	95	95	CD
cord-318495-1w74wf02	169	33	.	.	.
cord-318495-1w74wf02	170	1	RIG	rig	NN
cord-318495-1w74wf02	170	2	-	-	:
cord-318495-1w74wf02	170	3	I	-PRON-	PRP
cord-318495-1w74wf02	170	4	is	be	VBZ
cord-318495-1w74wf02	170	5	triggered	trigger	VBN
cord-318495-1w74wf02	170	6	by	by	IN
cord-318495-1w74wf02	170	7	binding	bind	VBG
cord-318495-1w74wf02	170	8	of	of	IN
cord-318495-1w74wf02	170	9	5′	5′	CD
cord-318495-1w74wf02	170	10	di	di	NN
cord-318495-1w74wf02	170	11	-	-	HYPH
cord-318495-1w74wf02	170	12	or	or	CC
cord-318495-1w74wf02	170	13	triphosphates	triphosphate	NNS
cord-318495-1w74wf02	170	14	present	present	JJ
cord-318495-1w74wf02	170	15	on	on	IN
cord-318495-1w74wf02	170	16	uncapped	uncapped	JJ
cord-318495-1w74wf02	170	17	RNA	RNA	NNP
cord-318495-1w74wf02	170	18	or	or	CC
cord-318495-1w74wf02	170	19	short	short	JJ
cord-318495-1w74wf02	170	20	regions	region	NNS
cord-318495-1w74wf02	170	21	of	of	IN
cord-318495-1w74wf02	170	22	double	double	RB
cord-318495-1w74wf02	170	23	-	-	HYPH
cord-318495-1w74wf02	170	24	stranded	stranded	JJ
cord-318495-1w74wf02	170	25	(	(	-LRB-
cord-318495-1w74wf02	170	26	ds)RNA	ds)RNA	NNP
cord-318495-1w74wf02	170	27	.	.	.
cord-318495-1w74wf02	171	1	Phosphatase	phosphatase	JJ
cord-318495-1w74wf02	171	2	treatment	treatment	NN
cord-318495-1w74wf02	171	3	suppresses	suppress	VBZ
cord-318495-1w74wf02	171	4	the	the	DT
cord-318495-1w74wf02	171	5	ability	ability	NN
cord-318495-1w74wf02	171	6	of	of	IN
cord-318495-1w74wf02	171	7	in	in	FW
cord-318495-1w74wf02	171	8	vitro	vitro	FW
cord-318495-1w74wf02	171	9	-	-	HYPH
cord-318495-1w74wf02	171	10	transcribed	transcribe	VBN
cord-318495-1w74wf02	171	11	copy	copy	NN
cord-318495-1w74wf02	171	12	-	-	HYPH
cord-318495-1w74wf02	171	13	back	back	NN
cord-318495-1w74wf02	171	14	DVGs	dvg	NNS
cord-318495-1w74wf02	171	15	to	to	TO
cord-318495-1w74wf02	171	16	trigger	trigger	VB
cord-318495-1w74wf02	171	17	IFN	IFN	NNP
cord-318495-1w74wf02	171	18	production	production	NN
cord-318495-1w74wf02	171	19	following	follow	VBG
cord-318495-1w74wf02	171	20	transfection	transfection	NN
cord-318495-1w74wf02	171	21	supporting	support	VBG
cord-318495-1w74wf02	171	22	the	the	DT
cord-318495-1w74wf02	171	23	role	role	NN
cord-318495-1w74wf02	171	24	of	of	IN
cord-318495-1w74wf02	171	25	RIG	rig	NN
cord-318495-1w74wf02	171	26	-	-	:
cord-318495-1w74wf02	171	27	I	-PRON-	PRP
cord-318495-1w74wf02	171	28	in	in	IN
cord-318495-1w74wf02	171	29	DVG	DVG	NNP
cord-318495-1w74wf02	171	30	sensing	sense	VBG
cord-318495-1w74wf02	171	31	91	91	CD
cord-318495-1w74wf02	171	32	,	,	,
cord-318495-1w74wf02	171	33	94	94	CD
cord-318495-1w74wf02	171	34	,	,	,
cord-318495-1w74wf02	171	35	96	96	CD
cord-318495-1w74wf02	171	36	.	.	.
cord-318495-1w74wf02	172	1	SeV	SeV	NNP
cord-318495-1w74wf02	172	2	DVGs	dvg	NNS
cord-318495-1w74wf02	172	3	can	can	MD
cord-318495-1w74wf02	172	4	also	also	RB
cord-318495-1w74wf02	172	5	associate	associate	VB
cord-318495-1w74wf02	172	6	with	with	IN
cord-318495-1w74wf02	172	7	melanoma	melanoma	NN
cord-318495-1w74wf02	172	8	differentiation	differentiation	NN
cord-318495-1w74wf02	172	9	-	-	HYPH
cord-318495-1w74wf02	172	10	associated	associate	VBN
cord-318495-1w74wf02	172	11	protein	protein	NN
cord-318495-1w74wf02	172	12	5	5	CD
cord-318495-1w74wf02	172	13	(	(	-LRB-
cord-318495-1w74wf02	172	14	MDA5	MDA5	NNP
cord-318495-1w74wf02	172	15	)	)	-RRB-
cord-318495-1w74wf02	172	16	88	88	CD
cord-318495-1w74wf02	172	17	,	,	,
cord-318495-1w74wf02	172	18	94	94	CD
cord-318495-1w74wf02	172	19	,	,	,
cord-318495-1w74wf02	172	20	but	but	CC
cord-318495-1w74wf02	172	21	the	the	DT
cord-318495-1w74wf02	172	22	role	role	NN
cord-318495-1w74wf02	172	23	for	for	IN
cord-318495-1w74wf02	172	24	MDA5	MDA5	NNP
cord-318495-1w74wf02	172	25	in	in	IN
cord-318495-1w74wf02	172	26	sensing	sense	VBG
cord-318495-1w74wf02	172	27	other	other	JJ
cord-318495-1w74wf02	172	28	DVGs	dvg	NNS
cord-318495-1w74wf02	172	29	is	be	VBZ
cord-318495-1w74wf02	172	30	less	less	RBR
cord-318495-1w74wf02	172	31	clear	clear	JJ
cord-318495-1w74wf02	172	32	99	99	CD
cord-318495-1w74wf02	172	33	,	,	,
cord-318495-1w74wf02	172	34	100	100	CD
cord-318495-1w74wf02	172	35	.	.	.
cord-318495-1w74wf02	173	1	Other	other	JJ
cord-318495-1w74wf02	173	2	cellular	cellular	JJ
cord-318495-1w74wf02	173	3	proteins	protein	NNS
cord-318495-1w74wf02	173	4	can	can	MD
cord-318495-1w74wf02	173	5	also	also	RB
cord-318495-1w74wf02	173	6	associate	associate	VB
cord-318495-1w74wf02	173	7	with	with	IN
cord-318495-1w74wf02	173	8	DVGs	dvg	NNS
cord-318495-1w74wf02	173	9	.	.	.
cord-318495-1w74wf02	174	1	For	for	IN
cord-318495-1w74wf02	174	2	example	example	NN
cord-318495-1w74wf02	174	3	,	,	,
cord-318495-1w74wf02	174	4	MeV	MeV	NNP
cord-318495-1w74wf02	174	5	DVGs	dvg	NNS
cord-318495-1w74wf02	174	6	associate	associate	JJ
cord-318495-1w74wf02	174	7	with	with	IN
cord-318495-1w74wf02	174	8	the	the	DT
cord-318495-1w74wf02	174	9	dsRNA	dsrna	NN
cord-318495-1w74wf02	174	10	binding	bind	VBG
cord-318495-1w74wf02	174	11	protein	protein	NN
cord-318495-1w74wf02	174	12	named	name	VBN
cord-318495-1w74wf02	174	13	protein	protein	NN
cord-318495-1w74wf02	174	14	activator	activator	NN
cord-318495-1w74wf02	174	15	of	of	IN
cord-318495-1w74wf02	174	16	the	the	DT
cord-318495-1w74wf02	174	17	interferon	interferon	NN
cord-318495-1w74wf02	174	18	-	-	HYPH
cord-318495-1w74wf02	174	19	induced	induce	VBN
cord-318495-1w74wf02	174	20	protein	protein	NN
cord-318495-1w74wf02	174	21	kinase	kinase	NN
cord-318495-1w74wf02	174	22	to	to	TO
cord-318495-1w74wf02	174	23	optimally	optimally	RB
cord-318495-1w74wf02	174	24	activate	activate	VB
cord-318495-1w74wf02	174	25	RIG	rig	NN
cord-318495-1w74wf02	174	26	-	-	:
cord-318495-1w74wf02	174	27	I	I	NNP
cord-318495-1w74wf02	174	28	96	96	CD
cord-318495-1w74wf02	174	29	.	.	.
cord-318495-1w74wf02	175	1	DVG	DVG	NNP
cord-318495-1w74wf02	175	2	-	-	HYPH
cord-318495-1w74wf02	175	3	induced	induce	VBN
cord-318495-1w74wf02	175	4	RLR	RLR	NNP
cord-318495-1w74wf02	175	5	signalling	signalling	NN
cord-318495-1w74wf02	175	6	is	be	VBZ
cord-318495-1w74wf02	175	7	not	not	RB
cord-318495-1w74wf02	175	8	simply	simply	RB
cord-318495-1w74wf02	175	9	a	a	DT
cord-318495-1w74wf02	175	10	result	result	NN
cord-318495-1w74wf02	175	11	of	of	IN
cord-318495-1w74wf02	175	12	higher	high	JJR
cord-318495-1w74wf02	175	13	viral	viral	JJ
cord-318495-1w74wf02	175	14	RNA	RNA	NNP
cord-318495-1w74wf02	175	15	content	content	NN
cord-318495-1w74wf02	175	16	in	in	IN
cord-318495-1w74wf02	175	17	the	the	DT
cord-318495-1w74wf02	175	18	infected	infected	JJ
cord-318495-1w74wf02	175	19	cells	cell	NNS
cord-318495-1w74wf02	175	20	,	,	,
cord-318495-1w74wf02	175	21	as	as	IN
cord-318495-1w74wf02	175	22	increasing	increase	VBG
cord-318495-1w74wf02	175	23	the	the	DT
cord-318495-1w74wf02	175	24	amount	amount	NN
cord-318495-1w74wf02	175	25	of	of	IN
cord-318495-1w74wf02	175	26	DVG	DVG	NNP
cord-318495-1w74wf02	175	27	-	-	HYPH
cord-318495-1w74wf02	175	28	deficient	deficient	JJ
cord-318495-1w74wf02	175	29	virus	virus	NN
cord-318495-1w74wf02	175	30	does	do	VBZ
cord-318495-1w74wf02	175	31	not	not	RB
cord-318495-1w74wf02	175	32	increase	increase	VB
cord-318495-1w74wf02	175	33	the	the	DT
cord-318495-1w74wf02	175	34	IFN	IFN	NNP
cord-318495-1w74wf02	175	35	response	response	NN
cord-318495-1w74wf02	175	36	54	54	CD
cord-318495-1w74wf02	175	37	,	,	,
cord-318495-1w74wf02	175	38	88	88	CD
cord-318495-1w74wf02	175	39	,	,	,
cord-318495-1w74wf02	175	40	92	92	CD
cord-318495-1w74wf02	175	41	.	.	.
cord-318495-1w74wf02	176	1	Importantly	importantly	RB
cord-318495-1w74wf02	176	2	,	,	,
cord-318495-1w74wf02	176	3	efficient	efficient	JJ
cord-318495-1w74wf02	176	4	sensing	sensing	NN
cord-318495-1w74wf02	176	5	of	of	IN
cord-318495-1w74wf02	176	6	copy	copy	NN
cord-318495-1w74wf02	176	7	-	-	HYPH
cord-318495-1w74wf02	176	8	back	back	NN
cord-318495-1w74wf02	176	9	DVGs	dvg	NNS
cord-318495-1w74wf02	176	10	occurs	occur	VBZ
cord-318495-1w74wf02	176	11	even	even	RB
cord-318495-1w74wf02	176	12	in	in	IN
cord-318495-1w74wf02	176	13	the	the	DT
cord-318495-1w74wf02	176	14	presence	presence	NN
cord-318495-1w74wf02	176	15	of	of	IN
cord-318495-1w74wf02	176	16	virus	virus	NN
cord-318495-1w74wf02	176	17	-	-	HYPH
cord-318495-1w74wf02	176	18	encoded	encode	VBN
cord-318495-1w74wf02	176	19	antagonists	antagonist	NNS
cord-318495-1w74wf02	176	20	of	of	IN
cord-318495-1w74wf02	176	21	the	the	DT
cord-318495-1w74wf02	176	22	cellular	cellular	JJ
cord-318495-1w74wf02	176	23	sensing	sensing	NN
cord-318495-1w74wf02	176	24	pathways	pathway	NNS
cord-318495-1w74wf02	176	25	88	88	CD
cord-318495-1w74wf02	176	26	,	,	,
cord-318495-1w74wf02	176	27	92	92	CD
cord-318495-1w74wf02	176	28	.	.	.
cord-318495-1w74wf02	177	1	These	these	DT
cord-318495-1w74wf02	177	2	observations	observation	NNS
cord-318495-1w74wf02	177	3	suggest	suggest	VBP
cord-318495-1w74wf02	177	4	that	that	IN
cord-318495-1w74wf02	177	5	unique	unique	JJ
cord-318495-1w74wf02	177	6	features	feature	NNS
cord-318495-1w74wf02	177	7	of	of	IN
cord-318495-1w74wf02	177	8	DVGs	dvg	NNS
cord-318495-1w74wf02	177	9	favour	favour	VBP
cord-318495-1w74wf02	177	10	their	-PRON-	PRP$
cord-318495-1w74wf02	177	11	detection	detection	NN
cord-318495-1w74wf02	177	12	during	during	IN
cord-318495-1w74wf02	177	13	infection	infection	NN
cord-318495-1w74wf02	177	14	.	.	.
cord-318495-1w74wf02	178	1	The	the	DT
cord-318495-1w74wf02	178	2	predicted	predict	VBN
cord-318495-1w74wf02	178	3	long	long	JJ
cord-318495-1w74wf02	178	4	dsRNA	dsrna	NN
cord-318495-1w74wf02	178	5	stretch	stretch	NN
cord-318495-1w74wf02	178	6	formed	form	VBN
cord-318495-1w74wf02	178	7	by	by	IN
cord-318495-1w74wf02	178	8	the	the	DT
cord-318495-1w74wf02	178	9	reverse	reverse	JJ
cord-318495-1w74wf02	178	10	complementary	complementary	JJ
cord-318495-1w74wf02	178	11	ends	end	NNS
cord-318495-1w74wf02	178	12	of	of	IN
cord-318495-1w74wf02	178	13	copyback	copyback	NN
cord-318495-1w74wf02	178	14	DVGs	dvg	NNS
cord-318495-1w74wf02	178	15	was	be	VBD
cord-318495-1w74wf02	178	16	thought	think	VBN
cord-318495-1w74wf02	178	17	to	to	TO
cord-318495-1w74wf02	178	18	be	be	VB
cord-318495-1w74wf02	178	19	a	a	DT
cord-318495-1w74wf02	178	20	critical	critical	JJ
cord-318495-1w74wf02	178	21	factor	factor	NN
cord-318495-1w74wf02	178	22	in	in	IN
cord-318495-1w74wf02	178	23	their	-PRON-	PRP$
cord-318495-1w74wf02	178	24	immunostimulatory	immunostimulatory	NN
cord-318495-1w74wf02	178	25	activity	activity	NN
cord-318495-1w74wf02	178	26	8	8	CD
cord-318495-1w74wf02	178	27	,	,	,
cord-318495-1w74wf02	178	28	99	99	CD
cord-318495-1w74wf02	178	29	,	,	,
cord-318495-1w74wf02	178	30	101	101	CD
cord-318495-1w74wf02	178	31	.	.	.
cord-318495-1w74wf02	179	1	However	however	RB
cord-318495-1w74wf02	179	2	,	,	,
cord-318495-1w74wf02	179	3	recent	recent	JJ
cord-318495-1w74wf02	179	4	evidence	evidence	NN
cord-318495-1w74wf02	179	5	demonstrates	demonstrate	VBZ
cord-318495-1w74wf02	179	6	the	the	DT
cord-318495-1w74wf02	179	7	existence	existence	NN
cord-318495-1w74wf02	179	8	of	of	IN
cord-318495-1w74wf02	179	9	additional	additional	JJ
cord-318495-1w74wf02	179	10	features	feature	NNS
cord-318495-1w74wf02	179	11	in	in	IN
cord-318495-1w74wf02	179	12	DVGs	dvg	NNS
cord-318495-1w74wf02	179	13	that	that	WDT
cord-318495-1w74wf02	179	14	have	have	VBP
cord-318495-1w74wf02	179	15	a	a	DT
cord-318495-1w74wf02	179	16	larger	large	JJR
cord-318495-1w74wf02	179	17	impact	impact	NN
cord-318495-1w74wf02	179	18	on	on	IN
cord-318495-1w74wf02	179	19	their	-PRON-	PRP$
cord-318495-1w74wf02	179	20	immunostimulatory	immunostimulatory	NN
cord-318495-1w74wf02	179	21	potential	potential	NN
cord-318495-1w74wf02	179	22	.	.	.
cord-318495-1w74wf02	180	1	Structural	structural	JJ
cord-318495-1w74wf02	180	2	modelling	modelling	NN
cord-318495-1w74wf02	180	3	identified	identify	VBD
cord-318495-1w74wf02	180	4	a	a	DT
cord-318495-1w74wf02	180	5	44	44	CD
cord-318495-1w74wf02	180	6	nucleotide	nucleotide	JJ
cord-318495-1w74wf02	180	7	(	(	-LRB-
cord-318495-1w74wf02	180	8	nt)-long	nt)-long	JJ
cord-318495-1w74wf02	180	9	stem	stem	NN
cord-318495-1w74wf02	180	10	-	-	HYPH
cord-318495-1w74wf02	180	11	loop	loop	NN
cord-318495-1w74wf02	180	12	motif	motif	NN
cord-318495-1w74wf02	180	13	(	(	-LRB-
cord-318495-1w74wf02	180	14	DVG	DVG	NNP
cord-318495-1w74wf02	180	15	)	)	-RRB-
cord-318495-1w74wf02	180	16	in	in	IN
cord-318495-1w74wf02	180	17	a	a	DT
cord-318495-1w74wf02	180	18	SeV	sev	NN
cord-318495-1w74wf02	180	19	DVG-546	DVG-546	NNP
cord-318495-1w74wf02	180	20	,	,	,
cord-318495-1w74wf02	180	21	a	a	DT
cord-318495-1w74wf02	180	22	well	well	RB
cord-318495-1w74wf02	180	23	-	-	HYPH
cord-318495-1w74wf02	180	24	characterized	characterize	VBN
cord-318495-1w74wf02	180	25	and	and	CC
cord-318495-1w74wf02	180	26	potent	potent	JJ
cord-318495-1w74wf02	180	27	immunostimulatory	immunostimulatory	JJ
cord-318495-1w74wf02	180	28	copy	copy	NN
cord-318495-1w74wf02	180	29	-	-	HYPH
cord-318495-1w74wf02	180	30	back	back	NN
cord-318495-1w74wf02	180	31	DVG	DVG	NNP
cord-318495-1w74wf02	180	32	,	,	,
cord-318495-1w74wf02	180	33	which	which	WDT
cord-318495-1w74wf02	180	34	was	be	VBD
cord-318495-1w74wf02	180	35	absent	absent	JJ
cord-318495-1w74wf02	180	36	in	in	IN
cord-318495-1w74wf02	180	37	the	the	DT
cord-318495-1w74wf02	180	38	SeV	sev	NN
cord-318495-1w74wf02	180	39	genome	genome	NN
cord-318495-1w74wf02	180	40	and	and	CC
cord-318495-1w74wf02	180	41	spans	span	VBZ
cord-318495-1w74wf02	180	42	the	the	DT
cord-318495-1w74wf02	180	43	unique	unique	JJ
cord-318495-1w74wf02	180	44	junction	junction	NN
cord-318495-1w74wf02	180	45	formed	form	VBN
cord-318495-1w74wf02	180	46	between	between	IN
cord-318495-1w74wf02	180	47	the	the	DT
cord-318495-1w74wf02	180	48	genomic	genomic	JJ
cord-318495-1w74wf02	180	49	break	break	NN
cord-318495-1w74wf02	180	50	and	and	CC
cord-318495-1w74wf02	180	51	rejoin	rejoin	VB
cord-318495-1w74wf02	180	52	points	point	NNS
cord-318495-1w74wf02	180	53	that	that	WDT
cord-318495-1w74wf02	180	54	form	form	VBP
cord-318495-1w74wf02	180	55	this	this	DT
cord-318495-1w74wf02	180	56	copy	copy	NN
cord-318495-1w74wf02	180	57	-	-	HYPH
cord-318495-1w74wf02	180	58	back	back	NN
cord-318495-1w74wf02	180	59	DVG	DVG	NNP
cord-318495-1w74wf02	180	60	.	.	.
cord-318495-1w74wf02	181	1	Deletion	deletion	NN
cord-318495-1w74wf02	181	2	of	of	IN
cord-318495-1w74wf02	181	3	DVG	DVG	NNP
cord-318495-1w74wf02	181	4	reduces	reduce	VBZ
cord-318495-1w74wf02	181	5	the	the	DT
cord-318495-1w74wf02	181	6	DVG	DVG	NNP
cord-318495-1w74wf02	181	7	immunostimulatory	immunostimulatory	NN
cord-318495-1w74wf02	181	8	activity	activity	NN
cord-318495-1w74wf02	181	9	,	,	,
cord-318495-1w74wf02	181	10	while	while	IN
cord-318495-1w74wf02	181	11	introduction	introduction	NN
cord-318495-1w74wf02	181	12	of	of	IN
cord-318495-1w74wf02	181	13	the	the	DT
cord-318495-1w74wf02	181	14	motif	motif	NN
cord-318495-1w74wf02	181	15	into	into	IN
cord-318495-1w74wf02	181	16	an	an	DT
cord-318495-1w74wf02	181	17	immunologically	immunologically	RB
cord-318495-1w74wf02	181	18	inert	inert	JJ
cord-318495-1w74wf02	181	19	RNA	RNA	NNP
cord-318495-1w74wf02	181	20	improves	improve	VBZ
cord-318495-1w74wf02	181	21	its	-PRON-	PRP$
cord-318495-1w74wf02	181	22	ability	ability	NN
cord-318495-1w74wf02	181	23	to	to	TO
cord-318495-1w74wf02	181	24	induce	induce	VB
cord-318495-1w74wf02	181	25	the	the	DT
cord-318495-1w74wf02	181	26	expression	expression	NN
cord-318495-1w74wf02	181	27	of	of	IN
cord-318495-1w74wf02	181	28	type	type	NN
cord-318495-1w74wf02	181	29	I	-PRON-	PRP
cord-318495-1w74wf02	181	30	IFNs	ifns	VBP
cord-318495-1w74wf02	181	31	and	and	CC
cord-318495-1w74wf02	181	32	IFN	IFN	NNP
cord-318495-1w74wf02	181	33	-	-	HYPH
cord-318495-1w74wf02	181	34	stimulated	stimulate	VBN
cord-318495-1w74wf02	181	35	genes	gene	NNS
cord-318495-1w74wf02	181	36	94	94	CD
cord-318495-1w74wf02	181	37	.	.	.
cord-318495-1w74wf02	182	1	DVG	DVG	NNP
cord-318495-1w74wf02	182	2	acts	act	VBZ
cord-318495-1w74wf02	182	3	in	in	IN
cord-318495-1w74wf02	182	4	concert	concert	NN
cord-318495-1w74wf02	182	5	with	with	IN
cord-318495-1w74wf02	182	6	the	the	DT
cord-318495-1w74wf02	182	7	5′-triphosphate	5′-triphosphate	CD
cord-318495-1w74wf02	182	8	motif	motif	NN
cord-318495-1w74wf02	182	9	to	to	TO
cord-318495-1w74wf02	182	10	activate	activate	VB
cord-318495-1w74wf02	182	11	RIG	rig	NN
cord-318495-1w74wf02	182	12	-	-	:
cord-318495-1w74wf02	182	13	I	-PRON-	PRP
cord-318495-1w74wf02	182	14	and	and	CC
cord-318495-1w74wf02	182	15	allows	allow	VBZ
cord-318495-1w74wf02	182	16	for	for	IN
cord-318495-1w74wf02	182	17	enhanced	enhance	VBN
cord-318495-1w74wf02	182	18	RLR	RLR	NNP
cord-318495-1w74wf02	182	19	polymerization	polymerization	NN
cord-318495-1w74wf02	182	20	,	,	,
cord-318495-1w74wf02	182	21	a	a	DT
cord-318495-1w74wf02	182	22	marker	marker	NN
cord-318495-1w74wf02	182	23	of	of	IN
cord-318495-1w74wf02	182	24	activation	activation	NN
cord-318495-1w74wf02	182	25	94	94	CD
cord-318495-1w74wf02	182	26	.	.	.
cord-318495-1w74wf02	183	1	DVG	DVG	NNP
cord-318495-1w74wf02	183	2	lose	lose	VBP
cord-318495-1w74wf02	183	3	immunostimulatory	immunostimulatory	NNP
cord-318495-1w74wf02	183	4	potential	potential	NN
cord-318495-1w74wf02	183	5	94	94	CD
cord-318495-1w74wf02	183	6	.	.	.
cord-318495-1w74wf02	184	1	Failure	failure	NN
cord-318495-1w74wf02	184	2	to	to	TO
cord-318495-1w74wf02	184	3	detect	detect	VB
cord-318495-1w74wf02	184	4	dsRNA	dsrna	NN
cord-318495-1w74wf02	184	5	through	through	IN
cord-318495-1w74wf02	184	6	immunostaining	immunostaine	VBG
cord-318495-1w74wf02	184	7	during	during	IN
cord-318495-1w74wf02	184	8	SeV	sev	JJ
cord-318495-1w74wf02	184	9	infection	infection	NN
cord-318495-1w74wf02	184	10	102	102	CD
cord-318495-1w74wf02	184	11	and	and	CC
cord-318495-1w74wf02	184	12	normal	normal	JJ
cord-318495-1w74wf02	184	13	immunostimulatory	immunostimulatory	NN
cord-318495-1w74wf02	184	14	activity	activity	NN
cord-318495-1w74wf02	184	15	following	follow	VBG
cord-318495-1w74wf02	184	16	disruption	disruption	NN
cord-318495-1w74wf02	184	17	of	of	IN
cord-318495-1w74wf02	184	18	the	the	DT
cord-318495-1w74wf02	184	19	complementarity	complementarity	NN
cord-318495-1w74wf02	184	20	between	between	IN
cord-318495-1w74wf02	184	21	the	the	DT
cord-318495-1w74wf02	184	22	5′	5′	CD
cord-318495-1w74wf02	184	23	and	and	CC
cord-318495-1w74wf02	184	24	3′	3′	CD
cord-318495-1w74wf02	184	25	ends	end	NNS
cord-318495-1w74wf02	184	26	of	of	IN
cord-318495-1w74wf02	184	27	copy	copy	NN
cord-318495-1w74wf02	184	28	-	-	HYPH
cord-318495-1w74wf02	184	29	back	back	NN
cord-318495-1w74wf02	184	30	SeV	sev	NN
cord-318495-1w74wf02	184	31	DVGs	dvg	NNS
cord-318495-1w74wf02	184	32	94	94	CD
cord-318495-1w74wf02	184	33	further	further	JJ
cord-318495-1w74wf02	184	34	support	support	VBP
cord-318495-1w74wf02	184	35	the	the	DT
cord-318495-1w74wf02	184	36	notion	notion	NN
cord-318495-1w74wf02	184	37	that	that	IN
cord-318495-1w74wf02	184	38	the	the	DT
cord-318495-1w74wf02	184	39	predicted	predict	VBN
cord-318495-1w74wf02	184	40	long	long	JJ
cord-318495-1w74wf02	184	41	complementary	complementary	JJ
cord-318495-1w74wf02	184	42	ends	end	NNS
cord-318495-1w74wf02	184	43	of	of	IN
cord-318495-1w74wf02	184	44	copy	copy	NN
cord-318495-1w74wf02	184	45	-	-	HYPH
cord-318495-1w74wf02	184	46	back	back	NN
cord-318495-1w74wf02	184	47	DVGs	dvg	NNS
cord-318495-1w74wf02	184	48	have	have	VBP
cord-318495-1w74wf02	184	49	a	a	DT
cord-318495-1w74wf02	184	50	minor	minor	JJ
cord-318495-1w74wf02	184	51	role	role	NN
cord-318495-1w74wf02	184	52	in	in	IN
cord-318495-1w74wf02	184	53	the	the	DT
cord-318495-1w74wf02	184	54	onset	onset	NN
cord-318495-1w74wf02	184	55	of	of	IN
cord-318495-1w74wf02	184	56	anti	anti	JJ
cord-318495-1w74wf02	184	57	-	-	JJ
cord-318495-1w74wf02	184	58	viral	viral	JJ
cord-318495-1w74wf02	184	59	immunity	immunity	NN
cord-318495-1w74wf02	184	60	.	.	.
cord-318495-1w74wf02	185	1	It	-PRON-	PRP
cord-318495-1w74wf02	185	2	remains	remain	VBZ
cord-318495-1w74wf02	185	3	to	to	TO
cord-318495-1w74wf02	185	4	be	be	VB
cord-318495-1w74wf02	185	5	determined	determine	VBN
cord-318495-1w74wf02	185	6	when	when	WRB
cord-318495-1w74wf02	185	7	and	and	CC
cord-318495-1w74wf02	185	8	how	how	WRB
cord-318495-1w74wf02	185	9	DVG	DVG	NNP
cord-318495-1w74wf02	185	10	70	70	CD
cord-318495-1w74wf02	185	11	-	-	SYM
cord-318495-1w74wf02	185	12	114	114	CD
cord-318495-1w74wf02	185	13	is	be	VBZ
cord-318495-1w74wf02	185	14	exposed	expose	VBN
cord-318495-1w74wf02	185	15	during	during	IN
cord-318495-1w74wf02	185	16	infection	infection	NN
cord-318495-1w74wf02	185	17	,	,	,
cord-318495-1w74wf02	185	18	and	and	CC
cord-318495-1w74wf02	185	19	whether	whether	IN
cord-318495-1w74wf02	185	20	similar	similar	JJ
cord-318495-1w74wf02	185	21	motifs	motif	NNS
cord-318495-1w74wf02	185	22	are	be	VBP
cord-318495-1w74wf02	185	23	present	present	JJ
cord-318495-1w74wf02	185	24	in	in	IN
cord-318495-1w74wf02	185	25	other	other	JJ
cord-318495-1w74wf02	185	26	highly	highly	RB
cord-318495-1w74wf02	185	27	immunostimulatory	immunostimulatory	JJ
cord-318495-1w74wf02	185	28	DVGs	dvg	NNS
cord-318495-1w74wf02	185	29	.	.	.
cord-318495-1w74wf02	186	1	DVG	DVG	NNP
cord-318495-1w74wf02	186	2	immunostimulation	immunostimulation	NN
cord-318495-1w74wf02	186	3	is	be	VBZ
cord-318495-1w74wf02	186	4	also	also	RB
cord-318495-1w74wf02	186	5	an	an	DT
cord-318495-1w74wf02	186	6	important	important	JJ
cord-318495-1w74wf02	186	7	factor	factor	NN
cord-318495-1w74wf02	186	8	in	in	IN
cord-318495-1w74wf02	186	9	the	the	DT
cord-318495-1w74wf02	186	10	modulation	modulation	NN
cord-318495-1w74wf02	186	11	of	of	IN
cord-318495-1w74wf02	186	12	infections	infection	NNS
cord-318495-1w74wf02	186	13	in	in	IN
cord-318495-1w74wf02	186	14	insects	insect	NNS
cord-318495-1w74wf02	186	15	.	.	.
cord-318495-1w74wf02	187	1	Similar	similar	JJ
cord-318495-1w74wf02	187	2	to	to	IN
cord-318495-1w74wf02	187	3	the	the	DT
cord-318495-1w74wf02	187	4	RIG	rig	NN
cord-318495-1w74wf02	187	5	-	-	:
cord-318495-1w74wf02	187	6	I	I	NNP
cord-318495-1w74wf02	187	7	and	and	CC
cord-318495-1w74wf02	187	8	MDA5	MDA5	NNP
cord-318495-1w74wf02	187	9	PRRs	prr	NNS
cord-318495-1w74wf02	187	10	in	in	IN
cord-318495-1w74wf02	187	11	mammals	mammal	NNS
cord-318495-1w74wf02	187	12	,	,	,
cord-318495-1w74wf02	187	13	insects	insect	NNS
cord-318495-1w74wf02	187	14	sense	sense	VBP
cord-318495-1w74wf02	187	15	viral	viral	JJ
cord-318495-1w74wf02	187	16	RNA	rna	NN
cord-318495-1w74wf02	187	17	through	through	IN
cord-318495-1w74wf02	187	18	the	the	DT
cord-318495-1w74wf02	187	19	protein	protein	NN
cord-318495-1w74wf02	187	20	Dicer-2	Dicer-2	NNP
cord-318495-1w74wf02	187	21	.	.	.
cord-318495-1w74wf02	188	1	This	this	DT
cord-318495-1w74wf02	188	2	protein	protein	NN
cord-318495-1w74wf02	188	3	processes	process	VBZ
cord-318495-1w74wf02	188	4	the	the	DT
cord-318495-1w74wf02	188	5	viral	viral	JJ
cord-318495-1w74wf02	188	6	RNA	RNA	NNP
cord-318495-1w74wf02	188	7	into	into	IN
cord-318495-1w74wf02	188	8	small	small	JJ
cord-318495-1w74wf02	188	9	interfering	interfere	VBG
cord-318495-1w74wf02	188	10	RNAs	rna	NNS
cord-318495-1w74wf02	188	11	that	that	WDT
cord-318495-1w74wf02	188	12	protect	protect	VBP
cord-318495-1w74wf02	188	13	insects	insect	NNS
cord-318495-1w74wf02	188	14	from	from	IN
cord-318495-1w74wf02	188	15	re	re	NN
cord-318495-1w74wf02	188	16	-	-	NN
cord-318495-1w74wf02	188	17	infection	infection	NN
cord-318495-1w74wf02	188	18	with	with	IN
cord-318495-1w74wf02	188	19	the	the	DT
cord-318495-1w74wf02	188	20	same	same	JJ
cord-318495-1w74wf02	188	21	virus	virus	NN
cord-318495-1w74wf02	188	22	103	103	CD
cord-318495-1w74wf02	188	23	.	.	.
cord-318495-1w74wf02	189	1	DVGs	dvg	NNS
cord-318495-1w74wf02	189	2	are	be	VBP
cord-318495-1w74wf02	189	3	the	the	DT
cord-318495-1w74wf02	189	4	primary	primary	JJ
cord-318495-1w74wf02	189	5	targets	target	NNS
cord-318495-1w74wf02	189	6	for	for	IN
cord-318495-1w74wf02	189	7	Dicer-2	Dicer-2	NNP
cord-318495-1w74wf02	189	8	(	(	-LRB-
cord-318495-1w74wf02	189	9	ref	ref	NN
cord-318495-1w74wf02	189	10	.	.	NNP
cord-318495-1w74wf02	189	11	103	103	CD
cord-318495-1w74wf02	189	12	)	)	-RRB-
cord-318495-1w74wf02	189	13	.	.	.
cord-318495-1w74wf02	190	1	These	these	DT
cord-318495-1w74wf02	190	2	observations	observation	NNS
cord-318495-1w74wf02	190	3	indicate	indicate	VBP
cord-318495-1w74wf02	190	4	that	that	IN
cord-318495-1w74wf02	190	5	the	the	DT
cord-318495-1w74wf02	190	6	immunostimulatory	immunostimulatory	NNP
cord-318495-1w74wf02	190	7	activity	activity	NN
cord-318495-1w74wf02	190	8	of	of	IN
cord-318495-1w74wf02	190	9	DVGs	dvg	NNS
cord-318495-1w74wf02	190	10	is	be	VBZ
cord-318495-1w74wf02	190	11	widespread	widespread	JJ
cord-318495-1w74wf02	190	12	and	and	CC
cord-318495-1w74wf02	190	13	may	may	MD
cord-318495-1w74wf02	190	14	have	have	VB
cord-318495-1w74wf02	190	15	a	a	DT
cord-318495-1w74wf02	190	16	significant	significant	JJ
cord-318495-1w74wf02	190	17	impact	impact	NN
cord-318495-1w74wf02	190	18	on	on	IN
cord-318495-1w74wf02	190	19	the	the	DT
cord-318495-1w74wf02	190	20	spread	spread	NN
cord-318495-1w74wf02	190	21	of	of	IN
cord-318495-1w74wf02	190	22	pathogens	pathogen	NNS
cord-318495-1w74wf02	190	23	within	within	IN
cord-318495-1w74wf02	190	24	and	and	CC
cord-318495-1w74wf02	190	25	across	across	IN
cord-318495-1w74wf02	190	26	species	specie	NNS
cord-318495-1w74wf02	190	27	.	.	.
cord-318495-1w74wf02	191	1	18	18	CD
cord-318495-1w74wf02	191	2	,	,	,
cord-318495-1w74wf02	191	3	108	108	CD
cord-318495-1w74wf02	191	4	,	,	,
cord-318495-1w74wf02	191	5	as	as	RB
cord-318495-1w74wf02	191	6	well	well	RB
cord-318495-1w74wf02	191	7	as	as	IN
cord-318495-1w74wf02	191	8	one	one	CD
cord-318495-1w74wf02	191	9	study	study	NN
cord-318495-1w74wf02	191	10	reporting	reporting	NN
cord-318495-1w74wf02	191	11	DVGs	dvg	NNS
cord-318495-1w74wf02	191	12	in	in	IN
cord-318495-1w74wf02	191	13	the	the	DT
cord-318495-1w74wf02	191	14	brain	brain	NN
cord-318495-1w74wf02	191	15	of	of	IN
cord-318495-1w74wf02	191	16	human	human	JJ
cord-318495-1w74wf02	191	17	patients	patient	NNS
cord-318495-1w74wf02	191	18	who	who	WP
cord-318495-1w74wf02	191	19	had	have	VBD
cord-318495-1w74wf02	191	20	died	die	VBN
cord-318495-1w74wf02	191	21	due	due	IN
cord-318495-1w74wf02	191	22	to	to	IN
cord-318495-1w74wf02	191	23	post	post	JJ
cord-318495-1w74wf02	191	24	-	-	JJ
cord-318495-1w74wf02	191	25	MeV	mev	JJ
cord-318495-1w74wf02	191	26	subacute	subacute	JJ
cord-318495-1w74wf02	191	27	sclerosing	sclerosing	NN
cord-318495-1w74wf02	191	28	panencephalitis	panencephalitis	NNP
cord-318495-1w74wf02	191	29	17	17	CD
cord-318495-1w74wf02	191	30	.	.	.
cord-318495-1w74wf02	192	1	DIPs	dip	NNS
cord-318495-1w74wf02	192	2	and	and	CC
cord-318495-1w74wf02	192	3	full	full	JJ
cord-318495-1w74wf02	192	4	-	-	HYPH
cord-318495-1w74wf02	192	5	length	length	NN
cord-318495-1w74wf02	192	6	viruses	virus	NNS
cord-318495-1w74wf02	192	7	cycle	cycle	VBP
cord-318495-1w74wf02	192	8	asynchronously	asynchronously	RB
cord-318495-1w74wf02	192	9	in	in	IN
cord-318495-1w74wf02	192	10	many	many	JJ
cord-318495-1w74wf02	192	11	persistent	persistent	JJ
cord-318495-1w74wf02	192	12	infections	infection	NNS
cord-318495-1w74wf02	192	13	in	in	IN
cord-318495-1w74wf02	192	14	vitro	vitro	NNP
cord-318495-1w74wf02	192	15	109	109	CD
cord-318495-1w74wf02	192	16	,	,	,
cord-318495-1w74wf02	192	17	110	110	CD
cord-318495-1w74wf02	192	18	and	and	CC
cord-318495-1w74wf02	192	19	in	in	IN
cord-318495-1w74wf02	192	20	vivo	vivo	NNP
cord-318495-1w74wf02	192	21	19	19	CD
cord-318495-1w74wf02	192	22	,	,	,
cord-318495-1w74wf02	192	23	109	109	CD
cord-318495-1w74wf02	192	24	.	.	.
cord-318495-1w74wf02	193	1	Cycling	cycling	NN
cord-318495-1w74wf02	193	2	occurs	occur	VBZ
cord-318495-1w74wf02	193	3	in	in	IN
cord-318495-1w74wf02	193	4	a	a	DT
cord-318495-1w74wf02	193	5	predictable	predictable	JJ
cord-318495-1w74wf02	193	6	pattern	pattern	NN
cord-318495-1w74wf02	193	7	and	and	CC
cord-318495-1w74wf02	193	8	has	have	VBZ
cord-318495-1w74wf02	193	9	been	be	VBN
cord-318495-1w74wf02	193	10	mathematically	mathematically	RB
cord-318495-1w74wf02	193	11	modelled	model	VBN
cord-318495-1w74wf02	193	12	using	use	VBG
cord-318495-1w74wf02	193	13	variations	variation	NNS
cord-318495-1w74wf02	193	14	of	of	IN
cord-318495-1w74wf02	193	15	the	the	DT
cord-318495-1w74wf02	193	16	predator	predator	NN
cord-318495-1w74wf02	193	17	-	-	HYPH
cord-318495-1w74wf02	193	18	prey	prey	NN
cord-318495-1w74wf02	193	19	model	model	NN
cord-318495-1w74wf02	193	20	111	111	CD
cord-318495-1w74wf02	193	21	.	.	.
cord-318495-1w74wf02	194	1	A	a	DT
cord-318495-1w74wf02	194	2	theory	theory	NN
cord-318495-1w74wf02	194	3	to	to	TO
cord-318495-1w74wf02	194	4	explain	explain	VB
cord-318495-1w74wf02	194	5	the	the	DT
cord-318495-1w74wf02	194	6	asynchronous	asynchronous	JJ
cord-318495-1w74wf02	194	7	cycling	cycling	NN
cord-318495-1w74wf02	194	8	of	of	IN
cord-318495-1w74wf02	194	9	full	full	JJ
cord-318495-1w74wf02	194	10	-	-	HYPH
cord-318495-1w74wf02	194	11	length	length	NN
cord-318495-1w74wf02	194	12	viral	viral	JJ
cord-318495-1w74wf02	194	13	genomes	genome	NNS
cord-318495-1w74wf02	194	14	and	and	CC
cord-318495-1w74wf02	194	15	DVGs	dvg	NNS
cord-318495-1w74wf02	194	16	during	during	IN
cord-318495-1w74wf02	194	17	persistency	persistency	NN
cord-318495-1w74wf02	194	18	was	be	VBD
cord-318495-1w74wf02	194	19	put	put	VBN
cord-318495-1w74wf02	194	20	forward	forward	RB
cord-318495-1w74wf02	194	21	in	in	IN
cord-318495-1w74wf02	194	22	1970	1970	CD
cord-318495-1w74wf02	194	23	(	(	-LRB-
cord-318495-1w74wf02	194	24	ref	ref	NN
cord-318495-1w74wf02	194	25	.	.	NNP
cord-318495-1w74wf02	194	26	3	3	CD
cord-318495-1w74wf02	194	27	)	)	-RRB-
cord-318495-1w74wf02	194	28	.	.	.
cord-318495-1w74wf02	195	1	This	this	DT
cord-318495-1w74wf02	195	2	theory	theory	NN
cord-318495-1w74wf02	195	3	,	,	,
cord-318495-1w74wf02	195	4	which	which	WDT
cord-318495-1w74wf02	195	5	is	be	VBZ
cord-318495-1w74wf02	195	6	based	base	VBN
cord-318495-1w74wf02	195	7	on	on	IN
cord-318495-1w74wf02	195	8	the	the	DT
cord-318495-1w74wf02	195	9	interference	interference	NN
cord-318495-1w74wf02	195	10	effect	effect	NN
cord-318495-1w74wf02	195	11	of	of	IN
cord-318495-1w74wf02	195	12	DVGs	dvg	NNS
cord-318495-1w74wf02	195	13	on	on	IN
cord-318495-1w74wf02	195	14	the	the	DT
cord-318495-1w74wf02	195	15	replication	replication	NN
cord-318495-1w74wf02	195	16	of	of	IN
cord-318495-1w74wf02	195	17	the	the	DT
cord-318495-1w74wf02	195	18	full	full	JJ
cord-318495-1w74wf02	195	19	-	-	HYPH
cord-318495-1w74wf02	195	20	length	length	NN
cord-318495-1w74wf02	195	21	genome	genome	NN
cord-318495-1w74wf02	195	22	,	,	,
cord-318495-1w74wf02	195	23	proposed	propose	VBD
cord-318495-1w74wf02	195	24	the	the	DT
cord-318495-1w74wf02	195	25	following	follow	VBG
cord-318495-1w74wf02	195	26	:	:	:
cord-318495-1w74wf02	195	27	DIPs	dip	NNS
cord-318495-1w74wf02	195	28	accumulate	accumulate	VBP
cord-318495-1w74wf02	195	29	during	during	IN
cord-318495-1w74wf02	195	30	virus	virus	NN
cord-318495-1w74wf02	195	31	replication	replication	NN
cord-318495-1w74wf02	195	32	until	until	IN
cord-318495-1w74wf02	195	33	they	-PRON-	PRP
cord-318495-1w74wf02	195	34	reach	reach	VBP
cord-318495-1w74wf02	195	35	high	high	JJ
cord-318495-1w74wf02	195	36	concentrations	concentration	NNS
cord-318495-1w74wf02	195	37	and	and	CC
cord-318495-1w74wf02	195	38	become	become	VB
cord-318495-1w74wf02	195	39	predominant	predominant	JJ
cord-318495-1w74wf02	195	40	.	.	.
cord-318495-1w74wf02	196	1	In	in	IN
cord-318495-1w74wf02	196	2	this	this	DT
cord-318495-1w74wf02	196	3	condition	condition	NN
cord-318495-1w74wf02	196	4	,	,	,
cord-318495-1w74wf02	196	5	DVGs	dvg	NNS
cord-318495-1w74wf02	196	6	interfere	interfere	VB
cord-318495-1w74wf02	196	7	with	with	IN
cord-318495-1w74wf02	196	8	the	the	DT
cord-318495-1w74wf02	196	9	replication	replication	NN
cord-318495-1w74wf02	196	10	of	of	IN
cord-318495-1w74wf02	196	11	the	the	DT
cord-318495-1w74wf02	196	12	full	full	JJ
cord-318495-1w74wf02	196	13	-	-	HYPH
cord-318495-1w74wf02	196	14	length	length	NN
cord-318495-1w74wf02	196	15	viral	viral	JJ
cord-318495-1w74wf02	196	16	genome	genome	NN
cord-318495-1w74wf02	196	17	by	by	IN
cord-318495-1w74wf02	196	18	competing	compete	VBG
cord-318495-1w74wf02	196	19	for	for	IN
cord-318495-1w74wf02	196	20	essential	essential	JJ
cord-318495-1w74wf02	196	21	replication	replication	NN
cord-318495-1w74wf02	196	22	machinery	machinery	NN
cord-318495-1w74wf02	196	23	,	,	,
cord-318495-1w74wf02	196	24	driving	drive	VBG
cord-318495-1w74wf02	196	25	a	a	DT
cord-318495-1w74wf02	196	26	reduction	reduction	NN
cord-318495-1w74wf02	196	27	in	in	IN
cord-318495-1w74wf02	196	28	the	the	DT
cord-318495-1w74wf02	196	29	full	full	JJ
cord-318495-1w74wf02	196	30	-	-	HYPH
cord-318495-1w74wf02	196	31	length	length	NN
cord-318495-1w74wf02	196	32	virus	virus	NN
cord-318495-1w74wf02	196	33	.	.	.
cord-318495-1w74wf02	197	1	During	during	IN
cord-318495-1w74wf02	197	2	this	this	DT
cord-318495-1w74wf02	197	3	process	process	NN
cord-318495-1w74wf02	197	4	,	,	,
cord-318495-1w74wf02	197	5	some	some	DT
cord-318495-1w74wf02	197	6	previously	previously	RB
cord-318495-1w74wf02	197	7	uninfected	uninfected	JJ
cord-318495-1w74wf02	197	8	cells	cell	NNS
cord-318495-1w74wf02	197	9	are	be	VBP
cord-318495-1w74wf02	197	10	infected	infect	VBN
cord-318495-1w74wf02	197	11	by	by	IN
cord-318495-1w74wf02	197	12	standard	standard	JJ
cord-318495-1w74wf02	197	13	virus	virus	NN
cord-318495-1w74wf02	197	14	and	and	CC
cord-318495-1w74wf02	197	15	re	re	NN
cord-318495-1w74wf02	197	16	-	-	VB
cord-318495-1w74wf02	197	17	initiate	initiate	VB
cord-318495-1w74wf02	197	18	the	the	DT
cord-318495-1w74wf02	197	19	cycle	cycle	NN
cord-318495-1w74wf02	197	20	.	.	.
cord-318495-1w74wf02	198	1	Interestingly	interestingly	RB
cord-318495-1w74wf02	198	2	,	,	,
cord-318495-1w74wf02	198	3	in	in	IN
cord-318495-1w74wf02	198	4	some	some	DT
cord-318495-1w74wf02	198	5	persistent	persistent	JJ
cord-318495-1w74wf02	198	6	infections	infection	NNS
cord-318495-1w74wf02	198	7	the	the	DT
cord-318495-1w74wf02	198	8	amount	amount	NN
cord-318495-1w74wf02	198	9	of	of	IN
cord-318495-1w74wf02	198	10	DIPs	dip	NNS
cord-318495-1w74wf02	198	11	appears	appear	VBZ
cord-318495-1w74wf02	198	12	constant	constant	JJ
cord-318495-1w74wf02	198	13	112	112	CD
cord-318495-1w74wf02	198	14	.	.	.
cord-318495-1w74wf02	199	1	What	what	WP
cord-318495-1w74wf02	199	2	drives	drive	VBZ
cord-318495-1w74wf02	199	3	these	these	DT
cord-318495-1w74wf02	199	4	cyclic	cyclic	JJ
cord-318495-1w74wf02	199	5	patterns	pattern	NNS
cord-318495-1w74wf02	199	6	in	in	IN
cord-318495-1w74wf02	199	7	some	some	DT
cord-318495-1w74wf02	199	8	viruses	virus	NNS
cord-318495-1w74wf02	199	9	but	but	CC
cord-318495-1w74wf02	199	10	not	not	RB
cord-318495-1w74wf02	199	11	others	other	NNS
cord-318495-1w74wf02	199	12	,	,	,
cord-318495-1w74wf02	199	13	and	and	CC
cord-318495-1w74wf02	199	14	whether	whether	IN
cord-318495-1w74wf02	199	15	host	host	NN
cord-318495-1w74wf02	199	16	factors	factor	NNS
cord-318495-1w74wf02	199	17	such	such	JJ
cord-318495-1w74wf02	199	18	as	as	IN
cord-318495-1w74wf02	199	19	the	the	DT
cord-318495-1w74wf02	199	20	infected	infected	JJ
cord-318495-1w74wf02	199	21	cell	cell	NN
cord-318495-1w74wf02	199	22	type	type	NN
cord-318495-1w74wf02	199	23	influences	influence	VBZ
cord-318495-1w74wf02	199	24	the	the	DT
cord-318495-1w74wf02	199	25	cycling	cycling	NN
cord-318495-1w74wf02	199	26	pattern	pattern	NN
cord-318495-1w74wf02	199	27	,	,	,
cord-318495-1w74wf02	199	28	remain	remain	VBP
cord-318495-1w74wf02	199	29	unknown	unknown	JJ
cord-318495-1w74wf02	199	30	.	.	.
cord-318495-1w74wf02	200	1	Recent	recent	JJ
cord-318495-1w74wf02	200	2	evidence	evidence	NN
cord-318495-1w74wf02	200	3	indicates	indicate	VBZ
cord-318495-1w74wf02	200	4	that	that	IN
cord-318495-1w74wf02	200	5	the	the	DT
cord-318495-1w74wf02	200	6	mechanisms	mechanism	NNS
cord-318495-1w74wf02	200	7	involved	involve	VBN
cord-318495-1w74wf02	200	8	in	in	IN
cord-318495-1w74wf02	200	9	the	the	DT
cord-318495-1w74wf02	200	10	establishment	establishment	NN
cord-318495-1w74wf02	200	11	of	of	IN
cord-318495-1w74wf02	200	12	persistence	persistence	NN
cord-318495-1w74wf02	200	13	are	be	VBP
cord-318495-1w74wf02	200	14	more	more	RBR
cord-318495-1w74wf02	200	15	complex	complex	JJ
cord-318495-1w74wf02	200	16	than	than	IN
cord-318495-1w74wf02	200	17	simple	simple	JJ
cord-318495-1w74wf02	200	18	intracellular	intracellular	JJ
cord-318495-1w74wf02	200	19	competition	competition	NN
cord-318495-1w74wf02	200	20	for	for	IN
cord-318495-1w74wf02	200	21	the	the	DT
cord-318495-1w74wf02	200	22	replication	replication	NN
cord-318495-1w74wf02	200	23	machinery	machinery	NN
cord-318495-1w74wf02	200	24	among	among	IN
cord-318495-1w74wf02	200	25	different	different	JJ
cord-318495-1w74wf02	200	26	types	type	NNS
cord-318495-1w74wf02	200	27	of	of	IN
cord-318495-1w74wf02	200	28	viral	viral	JJ
cord-318495-1w74wf02	200	29	genomes	genome	NNS
cord-318495-1w74wf02	200	30	87	87	CD
cord-318495-1w74wf02	200	31	.	.	.
cord-318495-1w74wf02	201	1	Using	use	VBG
cord-318495-1w74wf02	201	2	RNA	RNA	NNP
cord-318495-1w74wf02	201	3	in	in	IN
cord-318495-1w74wf02	201	4	situ	situ	JJ
cord-318495-1w74wf02	201	5	fluorescent	fluorescent	NN
cord-318495-1w74wf02	201	6	hybridization	hybridization	NN
cord-318495-1w74wf02	201	7	,	,	,
cord-318495-1w74wf02	201	8	Xu	Xu	NNP
cord-318495-1w74wf02	201	9	et	et	NNP
cord-318495-1w74wf02	201	10	al	al	NNP
cord-318495-1w74wf02	201	11	.	.	NNP
cord-318495-1w74wf02	201	12	showed	show	VBD
cord-318495-1w74wf02	201	13	that	that	IN
cord-318495-1w74wf02	201	14	during	during	IN
cord-318495-1w74wf02	201	15	infection	infection	NN
cord-318495-1w74wf02	201	16	with	with	IN
cord-318495-1w74wf02	201	17	SeV	SeV	NNS
cord-318495-1w74wf02	201	18	or	or	CC
cord-318495-1w74wf02	201	19	RSV	RSV	NNP
cord-318495-1w74wf02	201	20	containing	contain	VBG
cord-318495-1w74wf02	201	21	DIPs	dip	NNS
cord-318495-1w74wf02	201	22	,	,	,
cord-318495-1w74wf02	201	23	there	there	EX
cord-318495-1w74wf02	201	24	is	be	VBZ
cord-318495-1w74wf02	201	25	heterogeneity	heterogeneity	NN
cord-318495-1w74wf02	201	26	in	in	IN
cord-318495-1w74wf02	201	27	the	the	DT
cord-318495-1w74wf02	201	28	content	content	NN
cord-318495-1w74wf02	201	29	of	of	IN
cord-318495-1w74wf02	201	30	viral	viral	JJ
cord-318495-1w74wf02	201	31	genomes	genome	NNS
cord-318495-1w74wf02	201	32	in	in	IN
cord-318495-1w74wf02	201	33	the	the	DT
cord-318495-1w74wf02	201	34	infected	infected	JJ
cord-318495-1w74wf02	201	35	population	population	NN
cord-318495-1w74wf02	201	36	87	87	CD
cord-318495-1w74wf02	201	37	.	.	.
cord-318495-1w74wf02	202	1	While	while	IN
cord-318495-1w74wf02	202	2	some	some	DT
cord-318495-1w74wf02	202	3	cells	cell	NNS
cord-318495-1w74wf02	202	4	are	be	VBP
cord-318495-1w74wf02	202	5	enriched	enrich	VBN
cord-318495-1w74wf02	202	6	in	in	IN
cord-318495-1w74wf02	202	7	DVGs	dvg	NNS
cord-318495-1w74wf02	202	8	,	,	,
cord-318495-1w74wf02	202	9	others	other	NNS
cord-318495-1w74wf02	202	10	are	be	VBP
cord-318495-1w74wf02	202	11	enriched	enrich	VBN
cord-318495-1w74wf02	202	12	in	in	IN
cord-318495-1w74wf02	202	13	standard	standard	JJ
cord-318495-1w74wf02	202	14	full	full	JJ
cord-318495-1w74wf02	202	15	-	-	HYPH
cord-318495-1w74wf02	202	16	length	length	NN
cord-318495-1w74wf02	202	17	viral	viral	JJ
cord-318495-1w74wf02	202	18	genomes	genome	NNS
cord-318495-1w74wf02	202	19	.	.	.
cord-318495-1w74wf02	203	1	The	the	DT
cord-318495-1w74wf02	203	2	mechanisms	mechanism	NNS
cord-318495-1w74wf02	203	3	for	for	IN
cord-318495-1w74wf02	203	4	this	this	DT
cord-318495-1w74wf02	203	5	heterogeneity	heterogeneity	NN
cord-318495-1w74wf02	203	6	are	be	VBP
cord-318495-1w74wf02	203	7	currently	currently	RB
cord-318495-1w74wf02	203	8	unknown	unknown	JJ
cord-318495-1w74wf02	203	9	,	,	,
cord-318495-1w74wf02	203	10	however	however	RB
cord-318495-1w74wf02	203	11	,	,	,
cord-318495-1w74wf02	203	12	striking	strike	VBG
cord-318495-1w74wf02	203	13	functional	functional	JJ
cord-318495-1w74wf02	203	14	differences	difference	NNS
cord-318495-1w74wf02	203	15	among	among	IN
cord-318495-1w74wf02	203	16	these	these	DT
cord-318495-1w74wf02	203	17	cell	cell	NN
cord-318495-1w74wf02	203	18	populations	population	NNS
cord-318495-1w74wf02	203	19	are	be	VBP
cord-318495-1w74wf02	203	20	beginning	begin	VBG
cord-318495-1w74wf02	203	21	to	to	TO
cord-318495-1w74wf02	203	22	emerge	emerge	VB
cord-318495-1w74wf02	203	23	86	86	CD
cord-318495-1w74wf02	203	24	,	,	,
cord-318495-1w74wf02	203	25	87	87	CD
cord-318495-1w74wf02	203	26	.	.	.
cord-318495-1w74wf02	204	1	Cells	cell	NNS
cord-318495-1w74wf02	204	2	enriched	enrich	VBN
cord-318495-1w74wf02	204	3	in	in	IN
cord-318495-1w74wf02	204	4	DVGs	dvg	NNS
cord-318495-1w74wf02	204	5	engage	engage	VB
cord-318495-1w74wf02	204	6	the	the	DT
cord-318495-1w74wf02	204	7	RLR	RLR	NNP
cord-318495-1w74wf02	204	8	sensing	sensing	NN
cord-318495-1w74wf02	204	9	pathway	pathway	NN
cord-318495-1w74wf02	204	10	and	and	CC
cord-318495-1w74wf02	204	11	produce	produce	VBP
cord-318495-1w74wf02	204	12	IFNs	ifn	NNS
cord-318495-1w74wf02	204	13	and	and	CC
cord-318495-1w74wf02	204	14	other	other	JJ
cord-318495-1w74wf02	204	15	pro	pro	JJ
cord-318495-1w74wf02	204	16	-	-	JJ
cord-318495-1w74wf02	204	17	inflammatory	inflammatory	JJ
cord-318495-1w74wf02	204	18	molecules	molecule	NNS
cord-318495-1w74wf02	204	19	,	,	,
cord-318495-1w74wf02	204	20	including	include	VBG
cord-318495-1w74wf02	204	21	TNF	TNF	NNP
cord-318495-1w74wf02	204	22	.	.	.
cord-318495-1w74wf02	205	1	In	in	IN
cord-318495-1w74wf02	205	2	addition	addition	NN
cord-318495-1w74wf02	205	3	,	,	,
cord-318495-1w74wf02	205	4	these	these	DT
cord-318495-1w74wf02	205	5	cells	cell	NNS
cord-318495-1w74wf02	205	6	induce	induce	VBP
cord-318495-1w74wf02	205	7	a	a	DT
cord-318495-1w74wf02	205	8	pro	pro	JJ
cord-318495-1w74wf02	205	9	-	-	JJ
cord-318495-1w74wf02	205	10	survival	survival	JJ
cord-318495-1w74wf02	205	11	program	program	NN
cord-318495-1w74wf02	205	12	,	,	,
cord-318495-1w74wf02	205	13	also	also	RB
cord-318495-1w74wf02	205	14	dependent	dependent	JJ
cord-318495-1w74wf02	205	15	on	on	IN
cord-318495-1w74wf02	205	16	signalling	signal	VBG
cord-318495-1w74wf02	205	17	through	through	IN
cord-318495-1w74wf02	205	18	the	the	DT
cord-318495-1w74wf02	205	19	RLR	RLR	NNP
cord-318495-1w74wf02	205	20	pathway	pathway	NN
cord-318495-1w74wf02	205	21	.	.	.
cord-318495-1w74wf02	206	1	These	these	DT
cord-318495-1w74wf02	206	2	programs	program	NNS
cord-318495-1w74wf02	206	3	protect	protect	VBP
cord-318495-1w74wf02	206	4	DVG	DVG	NNP
cord-318495-1w74wf02	206	5	-	-	HYPH
cord-318495-1w74wf02	206	6	high	high	JJ
cord-318495-1w74wf02	206	7	cells	cell	NNS
cord-318495-1w74wf02	206	8	from	from	IN
cord-318495-1w74wf02	206	9	TNFmediated	tnfmediated	JJ
cord-318495-1w74wf02	206	10	death	death	NN
cord-318495-1w74wf02	206	11	,	,	,
cord-318495-1w74wf02	206	12	while	while	IN
cord-318495-1w74wf02	206	13	cells	cell	NNS
cord-318495-1w74wf02	206	14	lacking	lack	VBG
cord-318495-1w74wf02	206	15	DVGs	dvg	NNS
cord-318495-1w74wf02	206	16	die	die	VBP
cord-318495-1w74wf02	206	17	during	during	IN
cord-318495-1w74wf02	206	18	infection	infection	NN
cord-318495-1w74wf02	206	19	.	.	.
cord-318495-1w74wf02	207	1	Surviving	survive	VBG
cord-318495-1w74wf02	207	2	DVG	DVG	NNP
cord-318495-1w74wf02	207	3	-	-	HYPH
cord-318495-1w74wf02	207	4	high	high	JJ
cord-318495-1w74wf02	207	5	cells	cell	NNS
cord-318495-1w74wf02	207	6	can	can	MD
cord-318495-1w74wf02	207	7	be	be	VB
cord-318495-1w74wf02	207	8	propagated	propagate	VBN
cord-318495-1w74wf02	207	9	for	for	IN
cord-318495-1w74wf02	207	10	months	month	NNS
cord-318495-1w74wf02	207	11	as	as	IN
cord-318495-1w74wf02	207	12	a	a	DT
cord-318495-1w74wf02	207	13	persistent	persistent	JJ
cord-318495-1w74wf02	207	14	infection	infection	NN
cord-318495-1w74wf02	207	15	.	.	.
cord-318495-1w74wf02	208	1	This	this	DT
cord-318495-1w74wf02	208	2	mechanism	mechanism	NN
cord-318495-1w74wf02	208	3	provides	provide	VBZ
cord-318495-1w74wf02	208	4	an	an	DT
cord-318495-1w74wf02	208	5	explanation	explanation	NN
cord-318495-1w74wf02	208	6	for	for	IN
cord-318495-1w74wf02	208	7	the	the	DT
cord-318495-1w74wf02	208	8	paradoxical	paradoxical	JJ
cord-318495-1w74wf02	208	9	stimulation	stimulation	NN
cord-318495-1w74wf02	208	10	of	of	IN
cord-318495-1w74wf02	208	11	both	both	DT
cord-318495-1w74wf02	208	12	antiviral	antiviral	JJ
cord-318495-1w74wf02	208	13	immunity	immunity	NN
cord-318495-1w74wf02	208	14	and	and	CC
cord-318495-1w74wf02	208	15	establishment	establishment	NN
cord-318495-1w74wf02	208	16	of	of	IN
cord-318495-1w74wf02	208	17	persistence	persistence	NN
cord-318495-1w74wf02	208	18	by	by	IN
cord-318495-1w74wf02	208	19	DVGs	dvg	NNS
cord-318495-1w74wf02	208	20	.	.	.
cord-318495-1w74wf02	209	1	It	-PRON-	PRP
cord-318495-1w74wf02	209	2	remains	remain	VBZ
cord-318495-1w74wf02	209	3	unclear	unclear	JJ
cord-318495-1w74wf02	209	4	how	how	WRB
cord-318495-1w74wf02	209	5	the	the	DT
cord-318495-1w74wf02	209	6	enhanced	enhanced	JJ
cord-318495-1w74wf02	209	7	survival	survival	NN
cord-318495-1w74wf02	209	8	of	of	IN
cord-318495-1w74wf02	209	9	DVG	DVG	NNP
cord-318495-1w74wf02	209	10	-	-	HYPH
cord-318495-1w74wf02	209	11	high	high	JJ
cord-318495-1w74wf02	209	12	cells	cell	NNS
cord-318495-1w74wf02	209	13	leads	lead	VBZ
cord-318495-1w74wf02	209	14	to	to	IN
cord-318495-1w74wf02	209	15	persistence	persistence	NN
cord-318495-1w74wf02	209	16	,	,	,
cord-318495-1w74wf02	209	17	and	and	CC
cord-318495-1w74wf02	209	18	how	how	WRB
cord-318495-1w74wf02	209	19	this	this	DT
cord-318495-1w74wf02	209	20	survival	survival	NN
cord-318495-1w74wf02	209	21	fits	fit	VBZ
cord-318495-1w74wf02	209	22	into	into	IN
cord-318495-1w74wf02	209	23	the	the	DT
cord-318495-1w74wf02	209	24	cycling	cycling	NN
cord-318495-1w74wf02	209	25	of	of	IN
cord-318495-1w74wf02	209	26	DVG	DVG	NNP
cord-318495-1w74wf02	209	27	and	and	CC
cord-318495-1w74wf02	209	28	standard	standard	JJ
cord-318495-1w74wf02	209	29	virus	virus	NN
cord-318495-1w74wf02	209	30	observed	observe	VBN
cord-318495-1w74wf02	209	31	in	in	IN
cord-318495-1w74wf02	209	32	many	many	JJ
cord-318495-1w74wf02	209	33	infections	infection	NNS
cord-318495-1w74wf02	209	34	.	.	.
cord-318495-1w74wf02	210	1	Cycling	cycling	NN
cord-318495-1w74wf02	210	2	may	may	MD
cord-318495-1w74wf02	210	3	occur	occur	VB
cord-318495-1w74wf02	210	4	at	at	IN
cord-318495-1w74wf02	210	5	the	the	DT
cord-318495-1w74wf02	210	6	intracellular	intracellular	JJ
cord-318495-1w74wf02	210	7	level	level	NN
cord-318495-1w74wf02	210	8	(	(	-LRB-
cord-318495-1w74wf02	210	9	where	where	WRB
cord-318495-1w74wf02	210	10	each	each	DT
cord-318495-1w74wf02	210	11	infected	infect	VBN
cord-318495-1w74wf02	210	12	cell	cell	NN
cord-318495-1w74wf02	210	13	goes	go	VBZ
cord-318495-1w74wf02	210	14	through	through	IN
cord-318495-1w74wf02	210	15	cycles	cycle	NNS
cord-318495-1w74wf02	210	16	of	of	IN
cord-318495-1w74wf02	210	17	standard	standard	JJ
cord-318495-1w74wf02	210	18	viral	viral	JJ
cord-318495-1w74wf02	210	19	genome	genome	NN
cord-318495-1w74wf02	210	20	or	or	CC
cord-318495-1w74wf02	210	21	DVG	DVG	NNP
cord-318495-1w74wf02	210	22	enrichment	enrichment	NN
cord-318495-1w74wf02	210	23	driven	drive	VBN
cord-318495-1w74wf02	210	24	by	by	IN
cord-318495-1w74wf02	210	25	competition	competition	NN
cord-318495-1w74wf02	210	26	and	and	CC
cord-318495-1w74wf02	210	27	interference	interference	NN
cord-318495-1w74wf02	210	28	with	with	IN
cord-318495-1w74wf02	210	29	the	the	DT
cord-318495-1w74wf02	210	30	viral	viral	JJ
cord-318495-1w74wf02	210	31	replication	replication	NN
cord-318495-1w74wf02	210	32	machinery	machinery	NN
cord-318495-1w74wf02	210	33	)	)	-RRB-
cord-318495-1w74wf02	210	34	and/or	and/or	CC
cord-318495-1w74wf02	210	35	at	at	IN
cord-318495-1w74wf02	210	36	the	the	DT
cord-318495-1w74wf02	210	37	population	population	NN
cord-318495-1w74wf02	210	38	level	level	NN
cord-318495-1w74wf02	210	39	,	,	,
cord-318495-1w74wf02	210	40	where	where	WRB
cord-318495-1w74wf02	210	41	 	 	_SP
cord-318495-1w74wf02	210	42	The	the	DT
cord-318495-1w74wf02	210	43	strong	strong	JJ
cord-318495-1w74wf02	210	44	interfering	interfering	NN
cord-318495-1w74wf02	210	45	and	and	CC
cord-318495-1w74wf02	210	46	immunostimulatory	immunostimulatory	JJ
cord-318495-1w74wf02	210	47	activities	activity	NNS
cord-318495-1w74wf02	210	48	of	of	IN
cord-318495-1w74wf02	210	49	DVGs	dvg	NNS
cord-318495-1w74wf02	210	50	make	make	VBP
cord-318495-1w74wf02	210	51	them	-PRON-	PRP
cord-318495-1w74wf02	210	52	attractive	attractive	JJ
cord-318495-1w74wf02	210	53	candidates	candidate	NNS
cord-318495-1w74wf02	210	54	for	for	IN
cord-318495-1w74wf02	210	55	vaccine	vaccine	NN
cord-318495-1w74wf02	210	56	adjuvants	adjuvant	NNS
cord-318495-1w74wf02	210	57	and	and	CC
cord-318495-1w74wf02	210	58	antivirals	antiviral	NNS
cord-318495-1w74wf02	210	59	113	113	CD
cord-318495-1w74wf02	210	60	,	,	,
cord-318495-1w74wf02	210	61	114	114	CD
cord-318495-1w74wf02	210	62	.	.	.
cord-318495-1w74wf02	211	1	The	the	DT
cord-318495-1w74wf02	211	2	ability	ability	NN
cord-318495-1w74wf02	211	3	of	of	IN
cord-318495-1w74wf02	211	4	DIPs	dip	NNS
cord-318495-1w74wf02	211	5	to	to	TO
cord-318495-1w74wf02	211	6	interfere	interfere	VB
cord-318495-1w74wf02	211	7	with	with	IN
cord-318495-1w74wf02	211	8	the	the	DT
cord-318495-1w74wf02	211	9	replication	replication	NN
cord-318495-1w74wf02	211	10	of	of	IN
cord-318495-1w74wf02	211	11	standard	standard	JJ
cord-318495-1w74wf02	211	12	viruses	virus	NNS
cord-318495-1w74wf02	211	13	and	and	CC
cord-318495-1w74wf02	211	14	diminish	diminish	VB
cord-318495-1w74wf02	211	15	virus	virus	NN
cord-318495-1w74wf02	211	16	-	-	HYPH
cord-318495-1w74wf02	211	17	associated	associate	VBN
cord-318495-1w74wf02	211	18	disease	disease	NN
cord-318495-1w74wf02	211	19	has	have	VBZ
cord-318495-1w74wf02	211	20	been	be	VBN
cord-318495-1w74wf02	211	21	extensively	extensively	RB
cord-318495-1w74wf02	211	22	demonstrated	demonstrate	VBN
cord-318495-1w74wf02	211	23	in	in	IN
cord-318495-1w74wf02	211	24	mice	mouse	NNS
cord-318495-1w74wf02	211	25	during	during	IN
cord-318495-1w74wf02	211	26	infection	infection	NN
cord-318495-1w74wf02	211	27	with	with	IN
cord-318495-1w74wf02	211	28	virus	virus	NN
cord-318495-1w74wf02	211	29	stocks	stock	NNS
cord-318495-1w74wf02	211	30	containing	contain	VBG
cord-318495-1w74wf02	211	31	DIPs	dip	NNS
cord-318495-1w74wf02	211	32	4	4	CD
cord-318495-1w74wf02	211	33	,	,	,
cord-318495-1w74wf02	211	34	54	54	CD
cord-318495-1w74wf02	211	35	,	,	,
cord-318495-1w74wf02	211	36	75	75	CD
cord-318495-1w74wf02	211	37	,	,	,
cord-318495-1w74wf02	211	38	77	77	CD
cord-318495-1w74wf02	211	39	,	,	,
cord-318495-1w74wf02	211	40	115	115	CD
cord-318495-1w74wf02	211	41	,	,	,
cord-318495-1w74wf02	211	42	even	even	RB
cord-318495-1w74wf02	211	43	when	when	WRB
cord-318495-1w74wf02	211	44	the	the	DT
cord-318495-1w74wf02	211	45	vaccine	vaccine	NN
cord-318495-1w74wf02	211	46	contained	contain	VBD
cord-318495-1w74wf02	211	47	standard	standard	JJ
cord-318495-1w74wf02	211	48	virus	virus	NN
cord-318495-1w74wf02	211	49	inactivated	inactivate	VBN
cord-318495-1w74wf02	211	50	by	by	IN
cord-318495-1w74wf02	211	51	ultraviolet	ultraviolet	NN
cord-318495-1w74wf02	211	52	treatment	treatment	NN
cord-318495-1w74wf02	211	53	116	116	CD
cord-318495-1w74wf02	211	54	.	.	.
cord-318495-1w74wf02	212	1	A	a	DT
cord-318495-1w74wf02	212	2	similar	similar	JJ
cord-318495-1w74wf02	212	3	protection	protection	NN
cord-318495-1w74wf02	212	4	has	have	VBZ
cord-318495-1w74wf02	212	5	been	be	VBN
cord-318495-1w74wf02	212	6	reported	report	VBN
cord-318495-1w74wf02	212	7	in	in	IN
cord-318495-1w74wf02	212	8	ferrets	ferret	NNS
cord-318495-1w74wf02	212	9	vaccinated	vaccinate	VBN
cord-318495-1w74wf02	212	10	with	with	IN
cord-318495-1w74wf02	212	11	an	an	DT
cord-318495-1w74wf02	212	12	influenza	influenza	NN
cord-318495-1w74wf02	212	13	vaccine	vaccine	NN
cord-318495-1w74wf02	212	14	containing	contain	VBG
cord-318495-1w74wf02	212	15	only	only	RB
cord-318495-1w74wf02	212	16	DIPs	dip	NNS
cord-318495-1w74wf02	212	17	117	117	CD
cord-318495-1w74wf02	212	18	.	.	.
cord-318495-1w74wf02	213	1	Synthetically	synthetically	RB
cord-318495-1w74wf02	213	2	engineered	engineer	VBN
cord-318495-1w74wf02	213	3	DIPs	dip	NNS
cord-318495-1w74wf02	213	4	with	with	IN
cord-318495-1w74wf02	213	5	strong	strong	JJ
cord-318495-1w74wf02	213	6	interfering	interfere	VBG
cord-318495-1w74wf02	213	7	potential	potential	NN
cord-318495-1w74wf02	213	8	,	,	,
cord-318495-1w74wf02	213	9	or	or	CC
cord-318495-1w74wf02	213	10	'	'	``
cord-318495-1w74wf02	213	11	therapeutic	therapeutic	JJ
cord-318495-1w74wf02	213	12	interfering	interfere	VBG
cord-318495-1w74wf02	213	13	particles	particle	NNS
cord-318495-1w74wf02	213	14	(	(	-LRB-
cord-318495-1w74wf02	213	15	TIPs	tip	NNS
cord-318495-1w74wf02	213	16	)	)	-RRB-
cord-318495-1w74wf02	213	17	'	'	''
cord-318495-1w74wf02	213	18	,	,	,
cord-318495-1w74wf02	213	19	have	have	VBP
cord-318495-1w74wf02	213	20	been	be	VBN
cord-318495-1w74wf02	213	21	more	more	RBR
cord-318495-1w74wf02	213	22	recently	recently	RB
cord-318495-1w74wf02	213	23	proposed	propose	VBN
cord-318495-1w74wf02	213	24	as	as	IN
cord-318495-1w74wf02	213	25	a	a	DT
cord-318495-1w74wf02	213	26	possible	possible	JJ
cord-318495-1w74wf02	213	27	strategy	strategy	NN
cord-318495-1w74wf02	213	28	to	to	TO
cord-318495-1w74wf02	213	29	control	control	VB
cord-318495-1w74wf02	213	30	viral	viral	JJ
cord-318495-1w74wf02	213	31	infections	infection	NNS
cord-318495-1w74wf02	213	32	.	.	.
cord-318495-1w74wf02	214	1	TIPs	tip	NNS
cord-318495-1w74wf02	214	2	would	would	MD
cord-318495-1w74wf02	214	3	theoretically	theoretically	RB
cord-318495-1w74wf02	214	4	replicate	replicate	VB
cord-318495-1w74wf02	214	5	faster	fast	RBR
cord-318495-1w74wf02	214	6	than	than	IN
cord-318495-1w74wf02	214	7	the	the	DT
cord-318495-1w74wf02	214	8	wild	wild	JJ
cord-318495-1w74wf02	214	9	-	-	HYPH
cord-318495-1w74wf02	214	10	type	type	NN
cord-318495-1w74wf02	214	11	virus	virus	NN
cord-318495-1w74wf02	214	12	and	and	CC
cord-318495-1w74wf02	214	13	therefore	therefore	RB
cord-318495-1w74wf02	214	14	outcompete	outcompete	VB
cord-318495-1w74wf02	214	15	the	the	DT
cord-318495-1w74wf02	214	16	virus	virus	NN
cord-318495-1w74wf02	214	17	hindering	hinder	VBG
cord-318495-1w74wf02	214	18	spread	spread	NN
cord-318495-1w74wf02	214	19	and	and	CC
cord-318495-1w74wf02	214	20	transmission	transmission	NN
cord-318495-1w74wf02	214	21	.	.	.
cord-318495-1w74wf02	215	1	TIPs	tip	NNS
cord-318495-1w74wf02	215	2	would	would	MD
cord-318495-1w74wf02	215	3	have	have	VB
cord-318495-1w74wf02	215	4	the	the	DT
cord-318495-1w74wf02	215	5	advantage	advantage	NN
cord-318495-1w74wf02	215	6	of	of	IN
cord-318495-1w74wf02	215	7	being	be	VBG
cord-318495-1w74wf02	215	8	active	active	JJ
cord-318495-1w74wf02	215	9	only	only	RB
cord-318495-1w74wf02	215	10	in	in	IN
cord-318495-1w74wf02	215	11	organisms	organism	NNS
cord-318495-1w74wf02	215	12	already	already	RB
cord-318495-1w74wf02	215	13	infected	infect	VBN
cord-318495-1w74wf02	215	14	with	with	IN
cord-318495-1w74wf02	215	15	the	the	DT
cord-318495-1w74wf02	215	16	wild	wild	JJ
cord-318495-1w74wf02	215	17	-	-	HYPH
cord-318495-1w74wf02	215	18	type	type	NN
cord-318495-1w74wf02	215	19	virus	virus	NN
cord-318495-1w74wf02	215	20	due	due	IN
cord-318495-1w74wf02	215	21	to	to	IN
cord-318495-1w74wf02	215	22	their	-PRON-	PRP$
cord-318495-1w74wf02	215	23	dependence	dependence	NN
cord-318495-1w74wf02	215	24	on	on	IN
cord-318495-1w74wf02	215	25	a	a	DT
cord-318495-1w74wf02	215	26	helper	helper	NN
cord-318495-1w74wf02	215	27	virus	virus	NN
cord-318495-1w74wf02	215	28	to	to	TO
cord-318495-1w74wf02	215	29	replicate	replicate	VB
cord-318495-1w74wf02	215	30	118	118	CD
cord-318495-1w74wf02	215	31	,	,	,
cord-318495-1w74wf02	215	32	119	119	CD
cord-318495-1w74wf02	215	33	.	.	.
cord-318495-1w74wf02	216	1	Although	although	IN
cord-318495-1w74wf02	216	2	still	still	RB
cord-318495-1w74wf02	216	3	in	in	IN
cord-318495-1w74wf02	216	4	the	the	DT
cord-318495-1w74wf02	216	5	exploratory	exploratory	JJ
cord-318495-1w74wf02	216	6	phase	phase	NN
cord-318495-1w74wf02	216	7	,	,	,
cord-318495-1w74wf02	216	8	it	-PRON-	PRP
cord-318495-1w74wf02	216	9	remains	remain	VBZ
cord-318495-1w74wf02	216	10	to	to	TO
cord-318495-1w74wf02	216	11	be	be	VB
cord-318495-1w74wf02	216	12	determined	determine	VBN
cord-318495-1w74wf02	216	13	how	how	WRB
cord-318495-1w74wf02	216	14	TIPs	tip	NNS
cord-318495-1w74wf02	216	15	would	would	MD
cord-318495-1w74wf02	216	16	impact	impact	VB
cord-318495-1w74wf02	216	17	virus	virus	NN
cord-318495-1w74wf02	216	18	persistence	persistence	NN
cord-318495-1w74wf02	216	19	,	,	,
cord-318495-1w74wf02	216	20	the	the	DT
cord-318495-1w74wf02	216	21	generation	generation	NN
cord-318495-1w74wf02	216	22	of	of	IN
cord-318495-1w74wf02	216	23	adaptive	adaptive	JJ
cord-318495-1w74wf02	216	24	mutations	mutation	NNS
cord-318495-1w74wf02	216	25	and	and	CC
cord-318495-1w74wf02	216	26	the	the	DT
cord-318495-1w74wf02	216	27	generation	generation	NN
cord-318495-1w74wf02	216	28	of	of	IN
cord-318495-1w74wf02	216	29	new	new	JJ
cord-318495-1w74wf02	216	30	infectious	infectious	JJ
cord-318495-1w74wf02	216	31	viruses	virus	NNS
cord-318495-1w74wf02	216	32	by	by	IN
cord-318495-1w74wf02	216	33	complementation	complementation	NN
cord-318495-1w74wf02	216	34	.	.	.
cord-318495-1w74wf02	217	1	Whether	whether	IN
cord-318495-1w74wf02	217	2	protection	protection	NN
cord-318495-1w74wf02	217	3	elicited	elicit	VBN
cord-318495-1w74wf02	217	4	by	by	IN
cord-318495-1w74wf02	217	5	natural	natural	JJ
cord-318495-1w74wf02	217	6	or	or	CC
cord-318495-1w74wf02	217	7	synthetic	synthetic	JJ
cord-318495-1w74wf02	217	8	DIPs	dip	NNS
cord-318495-1w74wf02	217	9	is	be	VBZ
cord-318495-1w74wf02	217	10	due	due	JJ
cord-318495-1w74wf02	217	11	to	to	IN
cord-318495-1w74wf02	217	12	direct	direct	JJ
cord-318495-1w74wf02	217	13	interference	interference	NN
cord-318495-1w74wf02	217	14	with	with	IN
cord-318495-1w74wf02	217	15	the	the	DT
cord-318495-1w74wf02	217	16	standard	standard	JJ
cord-318495-1w74wf02	217	17	virus	virus	NN
cord-318495-1w74wf02	217	18	replication	replication	NN
cord-318495-1w74wf02	217	19	or	or	CC
cord-318495-1w74wf02	217	20	through	through	IN
cord-318495-1w74wf02	217	21	strong	strong	JJ
cord-318495-1w74wf02	217	22	immunostimulatory	immunostimulatory	JJR
cord-318495-1w74wf02	217	23	ability	ability	NN
cord-318495-1w74wf02	217	24	of	of	IN
cord-318495-1w74wf02	217	25	DVGs	dvg	NNS
cord-318495-1w74wf02	217	26	is	be	VBZ
cord-318495-1w74wf02	217	27	unclear	unclear	JJ
cord-318495-1w74wf02	217	28	.	.	.
cord-318495-1w74wf02	218	1	SeV	SeV	NNP
cord-318495-1w74wf02	218	2	copyback	copyback	NNP
cord-318495-1w74wf02	218	3	DVGs	dvg	NNS
cord-318495-1w74wf02	218	4	augment	augment	VBP
cord-318495-1w74wf02	218	5	the	the	DT
cord-318495-1w74wf02	218	6	antigen	antigen	NN
cord-318495-1w74wf02	218	7	presentation	presentation	NN
cord-318495-1w74wf02	218	8	capacity	capacity	NN
cord-318495-1w74wf02	218	9	of	of	IN
cord-318495-1w74wf02	218	10	mouse	mouse	NN
cord-318495-1w74wf02	218	11	and	and	CC
cord-318495-1w74wf02	218	12	human	human	JJ
cord-318495-1w74wf02	218	13	dendritic	dendritic	JJ
cord-318495-1w74wf02	218	14	cells	cell	NNS
cord-318495-1w74wf02	218	15	,	,	,
cord-318495-1w74wf02	218	16	resulting	result	VBG
cord-318495-1w74wf02	218	17	in	in	IN
cord-318495-1w74wf02	218	18	enhanced	enhanced	JJ
cord-318495-1w74wf02	218	19	activation	activation	NN
cord-318495-1w74wf02	218	20	of	of	IN
cord-318495-1w74wf02	218	21	T	T	NNP
cord-318495-1w74wf02	218	22	cells	cell	NNS
cord-318495-1w74wf02	218	23	91	91	CD
cord-318495-1w74wf02	218	24	.	.	.
cord-318495-1w74wf02	219	1	In	in	IN
cord-318495-1w74wf02	219	2	addition	addition	NN
cord-318495-1w74wf02	219	3	,	,	,
cord-318495-1w74wf02	219	4	experimental	experimental	JJ
cord-318495-1w74wf02	219	5	vaccines	vaccine	NNS
cord-318495-1w74wf02	219	6	against	against	IN
cord-318495-1w74wf02	219	7	influenza	influenza	NN
cord-318495-1w74wf02	219	8	virus	virus	NN
cord-318495-1w74wf02	219	9	and	and	CC
cord-318495-1w74wf02	219	10	RSV	RSV	NNP
cord-318495-1w74wf02	219	11	adjuvanted	adjuvante	VBD
cord-318495-1w74wf02	219	12	with	with	IN
cord-318495-1w74wf02	219	13	in	in	FW
cord-318495-1w74wf02	219	14	vitro	vitro	FW
cord-318495-1w74wf02	219	15	-	-	HYPH
cord-318495-1w74wf02	219	16	transcribed	transcribe	VBN
cord-318495-1w74wf02	219	17	SeV	sev	NN
cord-318495-1w74wf02	219	18	DVGs	dvg	NNS
cord-318495-1w74wf02	219	19	delivered	deliver	VBN
cord-318495-1w74wf02	219	20	subcutaneously	subcutaneously	RB
cord-318495-1w74wf02	219	21	,	,	,
cord-318495-1w74wf02	219	22	intramuscularly	intramuscularly	RB
cord-318495-1w74wf02	219	23	or	or	CC
cord-318495-1w74wf02	219	24	intranasally	intranasally	RB
cord-318495-1w74wf02	219	25	show	show	VB
cord-318495-1w74wf02	219	26	improved	improve	VBN
cord-318495-1w74wf02	219	27	antibody	antibody	NN
cord-318495-1w74wf02	219	28	production	production	NN
cord-318495-1w74wf02	219	29	and	and	CC
cord-318495-1w74wf02	219	30	increased	increase	VBN
cord-318495-1w74wf02	219	31	protection	protection	NN
cord-318495-1w74wf02	219	32	from	from	IN
cord-318495-1w74wf02	219	33	virus	virus	NN
cord-318495-1w74wf02	219	34	challenge	challenge	NN
cord-318495-1w74wf02	219	35	91	91	CD
cord-318495-1w74wf02	219	36	,	,	,
cord-318495-1w74wf02	219	37	120	120	CD
cord-318495-1w74wf02	219	38	.	.	.
cord-318495-1w74wf02	220	1	SeV	SeV	NNP
cord-318495-1w74wf02	220	2	DVG	DVG	NNP
cord-318495-1w74wf02	220	3	-	-	HYPH
cord-318495-1w74wf02	220	4	derived	derive	VBN
cord-318495-1w74wf02	220	5	oligonucleotides	oligonucleotide	NNS
cord-318495-1w74wf02	220	6	(	(	-LRB-
cord-318495-1w74wf02	220	7	DDOs	DDOs	NNP
cord-318495-1w74wf02	220	8	)	)	-RRB-
cord-318495-1w74wf02	220	9	containing	contain	VBG
cord-318495-1w74wf02	220	10	the	the	DT
cord-318495-1w74wf02	220	11	immunostimulatory	immunostimulatory	NNP
cord-318495-1w74wf02	220	12	motif	motif	NN
cord-318495-1w74wf02	221	1	DVG	DVG	NNP
cord-318495-1w74wf02	221	2	are	be	VBP
cord-318495-1w74wf02	221	3	effective	effective	JJ
cord-318495-1w74wf02	221	4	adjuvants	adjuvant	NNS
cord-318495-1w74wf02	221	5	able	able	JJ
cord-318495-1w74wf02	221	6	to	to	TO
cord-318495-1w74wf02	221	7	bias	bias	VB
cord-318495-1w74wf02	221	8	the	the	DT
cord-318495-1w74wf02	221	9	humoral	humoral	JJ
cord-318495-1w74wf02	221	10	and	and	CC
cord-318495-1w74wf02	221	11	cellular	cellular	JJ
cord-318495-1w74wf02	221	12	responses	response	NNS
cord-318495-1w74wf02	221	13	against	against	IN
cord-318495-1w74wf02	221	14	inactivated	inactivate	VBN
cord-318495-1w74wf02	221	15	virus	virus	NN
cord-318495-1w74wf02	221	16	and	and	CC
cord-318495-1w74wf02	221	17	protein	protein	NN
cord-318495-1w74wf02	221	18	vaccines	vaccine	NNS
cord-318495-1w74wf02	221	19	towards	towards	IN
cord-318495-1w74wf02	221	20	type	type	NN
cord-318495-1w74wf02	222	1	I	-PRON-	PRP
cord-318495-1w74wf02	222	2	immune	immune	VBP
cord-318495-1w74wf02	222	3	responses	response	NNS
cord-318495-1w74wf02	222	4	including	include	VBG
cord-318495-1w74wf02	222	5	antibodies	antibody	NNS
cord-318495-1w74wf02	222	6	of	of	IN
cord-318495-1w74wf02	222	7	the	the	DT
cord-318495-1w74wf02	222	8	IgG2a	IgG2a	NNP
cord-318495-1w74wf02	222	9	/	/	SYM
cord-318495-1w74wf02	222	10	c	c	NNP
cord-318495-1w74wf02	222	11	isotypes	isotypes	NNP
cord-318495-1w74wf02	222	12	,	,	,
cord-318495-1w74wf02	222	13	Th1	Th1	NNP
cord-318495-1w74wf02	222	14	CD4	CD4	NNP
cord-318495-1w74wf02	222	15	+	+	CC
cord-318495-1w74wf02	222	16	T	t	NN
cord-318495-1w74wf02	222	17	cells	cell	NNS
cord-318495-1w74wf02	222	18	and	and	CC
cord-318495-1w74wf02	222	19	cytotoxic	cytotoxic	JJ
cord-318495-1w74wf02	222	20	CD8	CD8	NNP
cord-318495-1w74wf02	222	21	+	+	CC
cord-318495-1w74wf02	222	22	T	T	NNP
cord-318495-1w74wf02	222	23	cells	cell	NNS
cord-318495-1w74wf02	222	24	in	in	IN
cord-318495-1w74wf02	222	25	mice	mice	NN
cord-318495-1w74wf02	222	26	91	91	CD
cord-318495-1w74wf02	222	27	,	,	,
cord-318495-1w74wf02	222	28	121	121	CD
cord-318495-1w74wf02	222	29	.	.	.
cord-318495-1w74wf02	223	1	DDOs	ddo	NNS
cord-318495-1w74wf02	223	2	also	also	RB
cord-318495-1w74wf02	223	3	synergize	synergize	VBP
cord-318495-1w74wf02	223	4	with	with	IN
cord-318495-1w74wf02	223	5	the	the	DT
cord-318495-1w74wf02	223	6	emulsion	emulsion	NN
cord-318495-1w74wf02	223	7	antibody	antibody	NN
cord-318495-1w74wf02	223	8	AddaVax	AddaVax	NNP
cord-318495-1w74wf02	223	9	and	and	CC
cord-318495-1w74wf02	223	10	enhance	enhance	VB
cord-318495-1w74wf02	223	11	its	-PRON-	PRP$
cord-318495-1w74wf02	223	12	type	type	NN
cord-318495-1w74wf02	224	1	I	-PRON-	PRP
cord-318495-1w74wf02	224	2	immunity	immunity	NN
cord-318495-1w74wf02	224	3	-	-	HYPH
cord-318495-1w74wf02	224	4	driving	drive	VBG
cord-318495-1w74wf02	224	5	potential	potential	NN
cord-318495-1w74wf02	224	6	by	by	IN
cord-318495-1w74wf02	224	7	mechanisms	mechanism	NNS
cord-318495-1w74wf02	224	8	that	that	WDT
cord-318495-1w74wf02	224	9	depends	depend	VBZ
cord-318495-1w74wf02	224	10	on	on	IN
cord-318495-1w74wf02	224	11	type	type	NN
cord-318495-1w74wf02	225	1	I	-PRON-	PRP
cord-318495-1w74wf02	225	2	IFNs	ifns	VBP
cord-318495-1w74wf02	225	3	121	121	CD
cord-318495-1w74wf02	225	4	.	.	.
cord-318495-1w74wf02	226	1	Notably	notably	RB
cord-318495-1w74wf02	226	2	,	,	,
cord-318495-1w74wf02	226	3	a	a	DT
cord-318495-1w74wf02	226	4	DIP	dip	NN
cord-318495-1w74wf02	226	5	influenza	influenza	NN
cord-318495-1w74wf02	226	6	vaccine	vaccine	NN
cord-318495-1w74wf02	226	7	conferred	confer	VBD
cord-318495-1w74wf02	226	8	protection	protection	NN
cord-318495-1w74wf02	226	9	to	to	IN
cord-318495-1w74wf02	226	10	an	an	DT
cord-318495-1w74wf02	226	11	unrelated	unrelated	JJ
cord-318495-1w74wf02	226	12	virus	virus	NN
cord-318495-1w74wf02	226	13	through	through	IN
cord-318495-1w74wf02	226	14	stimulation	stimulation	NN
cord-318495-1w74wf02	226	15	of	of	IN
cord-318495-1w74wf02	226	16	type	type	NN
cord-318495-1w74wf02	227	1	I	-PRON-	PRP
cord-318495-1w74wf02	227	2	IFN	IFN	NNP
cord-318495-1w74wf02	227	3	production	production	NN
cord-318495-1w74wf02	227	4	122	122	CD
cord-318495-1w74wf02	227	5	,	,	,
cord-318495-1w74wf02	227	6	suggesting	suggest	VBG
cord-318495-1w74wf02	227	7	that	that	IN
cord-318495-1w74wf02	227	8	they	-PRON-	PRP
cord-318495-1w74wf02	227	9	can	can	MD
cord-318495-1w74wf02	227	10	be	be	VB
cord-318495-1w74wf02	227	11	used	use	VBN
cord-318495-1w74wf02	227	12	as	as	IN
cord-318495-1w74wf02	227	13	prophylactic	prophylactic	JJ
cord-318495-1w74wf02	227	14	or	or	CC
cord-318495-1w74wf02	227	15	therapeutic	therapeutic	JJ
cord-318495-1w74wf02	227	16	antivirals	antiviral	NNS
cord-318495-1w74wf02	227	17	.	.	.
cord-318495-1w74wf02	228	1	DVGs	dvg	NNS
cord-318495-1w74wf02	228	2	are	be	VBP
cord-318495-1w74wf02	228	3	present	present	JJ
cord-318495-1w74wf02	228	4	in	in	IN
cord-318495-1w74wf02	228	5	live	live	JJ
cord-318495-1w74wf02	228	6	attenuated	attenuated	JJ
cord-318495-1w74wf02	228	7	vaccines	vaccine	NNS
cord-318495-1w74wf02	228	8	against	against	IN
cord-318495-1w74wf02	228	9	polio	polio	NN
cord-318495-1w74wf02	228	10	,	,	,
cord-318495-1w74wf02	228	11	measles	measle	NNS
cord-318495-1w74wf02	228	12	and	and	CC
cord-318495-1w74wf02	228	13	influenza	influenza	NN
cord-318495-1w74wf02	228	14	viruses	viruse	VBZ
cord-318495-1w74wf02	228	15	76	76	CD
cord-318495-1w74wf02	228	16	,	,	,
cord-318495-1w74wf02	228	17	[	[	-LRB-
cord-318495-1w74wf02	228	18	123	123	CD
cord-318495-1w74wf02	228	19	]	]	-RRB-
cord-318495-1w74wf02	228	20	[	[	-LRB-
cord-318495-1w74wf02	228	21	124	124	CD
cord-318495-1w74wf02	228	22	]	]	-RRB-
cord-318495-1w74wf02	228	23	[	[	-LRB-
cord-318495-1w74wf02	228	24	125	125	CD
cord-318495-1w74wf02	228	25	]	]	-RRB-
cord-318495-1w74wf02	228	26	[	[	-LRB-
cord-318495-1w74wf02	228	27	126	126	CD
cord-318495-1w74wf02	228	28	]	]	-RRB-
cord-318495-1w74wf02	228	29	.	.	.
cord-318495-1w74wf02	229	1	However	however	RB
cord-318495-1w74wf02	229	2	,	,	,
cord-318495-1w74wf02	229	3	their	-PRON-	PRP$
cord-318495-1w74wf02	229	4	impact	impact	NN
cord-318495-1w74wf02	229	5	in	in	IN
cord-318495-1w74wf02	229	6	the	the	DT
cord-318495-1w74wf02	229	7	development	development	NN
cord-318495-1w74wf02	229	8	of	of	IN
cord-318495-1w74wf02	229	9	protective	protective	JJ
cord-318495-1w74wf02	229	10	immunity	immunity	NN
cord-318495-1w74wf02	229	11	and	and	CC
cord-318495-1w74wf02	229	12	vaccine	vaccine	NN
cord-318495-1w74wf02	229	13	efficacy	efficacy	NN
cord-318495-1w74wf02	229	14	has	have	VBZ
cord-318495-1w74wf02	229	15	not	not	RB
cord-318495-1w74wf02	229	16	been	be	VBN
cord-318495-1w74wf02	229	17	formally	formally	RB
cord-318495-1w74wf02	229	18	assessed	assess	VBN
cord-318495-1w74wf02	229	19	.	.	.
cord-318495-1w74wf02	230	1	Based	base	VBN
cord-318495-1w74wf02	230	2	on	on	IN
cord-318495-1w74wf02	230	3	their	-PRON-	PRP$
cord-318495-1w74wf02	230	4	interfering	interfere	VBG
cord-318495-1w74wf02	230	5	and	and	CC
cord-318495-1w74wf02	230	6	immunostimulatory	immunostimulatory	JJ
cord-318495-1w74wf02	230	7	ability	ability	NN
cord-318495-1w74wf02	230	8	,	,	,
cord-318495-1w74wf02	230	9	it	-PRON-	PRP
cord-318495-1w74wf02	230	10	is	be	VBZ
cord-318495-1w74wf02	230	11	speculated	speculate	VBN
cord-318495-1w74wf02	230	12	that	that	IN
cord-318495-1w74wf02	230	13	DVGs	dvg	NNS
cord-318495-1w74wf02	230	14	may	may	MD
cord-318495-1w74wf02	230	15	enhance	enhance	VB
cord-318495-1w74wf02	230	16	the	the	DT
cord-318495-1w74wf02	230	17	efficiency	efficiency	NN
cord-318495-1w74wf02	230	18	of	of	IN
cord-318495-1w74wf02	230	19	the	the	DT
cord-318495-1w74wf02	230	20	vaccine	vaccine	NN
cord-318495-1w74wf02	230	21	while	while	IN
cord-318495-1w74wf02	230	22	enhancing	enhance	VBG
cord-318495-1w74wf02	230	23	safety	safety	NN
cord-318495-1w74wf02	230	24	of	of	IN
cord-318495-1w74wf02	230	25	the	the	DT
cord-318495-1w74wf02	230	26	virus	virus	NN
cord-318495-1w74wf02	230	27	by	by	IN
cord-318495-1w74wf02	230	28	reducing	reduce	VBG
cord-318495-1w74wf02	230	29	its	-PRON-	PRP$
cord-318495-1w74wf02	230	30	replication	replication	NN
cord-318495-1w74wf02	230	31	and	and	CC
cord-318495-1w74wf02	230	32	spread	spread	NN
cord-318495-1w74wf02	230	33	.	.	.
cord-318495-1w74wf02	231	1	If	if	IN
cord-318495-1w74wf02	231	2	correct	correct	JJ
cord-318495-1w74wf02	231	3	,	,	,
cord-318495-1w74wf02	231	4	it	-PRON-	PRP
cord-318495-1w74wf02	231	5	would	would	MD
cord-318495-1w74wf02	231	6	be	be	VB
cord-318495-1w74wf02	231	7	important	important	JJ
cord-318495-1w74wf02	231	8	to	to	TO
cord-318495-1w74wf02	231	9	carefully	carefully	RB
cord-318495-1w74wf02	231	10	regulate	regulate	VB
cord-318495-1w74wf02	231	11	the	the	DT
cord-318495-1w74wf02	231	12	amount	amount	NN
cord-318495-1w74wf02	231	13	of	of	IN
cord-318495-1w74wf02	231	14	DVGs	dvg	NNS
cord-318495-1w74wf02	231	15	in	in	IN
cord-318495-1w74wf02	231	16	vaccine	vaccine	NN
cord-318495-1w74wf02	231	17	preparations	preparation	NNS
cord-318495-1w74wf02	231	18	to	to	TO
cord-318495-1w74wf02	231	19	avoid	avoid	VB
cord-318495-1w74wf02	231	20	complete	complete	JJ
cord-318495-1w74wf02	231	21	interference	interference	NN
cord-318495-1w74wf02	231	22	and	and	CC
cord-318495-1w74wf02	231	23	drastic	drastic	JJ
cord-318495-1w74wf02	231	24	reduction	reduction	NN
cord-318495-1w74wf02	231	25	of	of	IN
cord-318495-1w74wf02	231	26	the	the	DT
cord-318495-1w74wf02	231	27	virus	virus	NN
cord-318495-1w74wf02	231	28	to	to	IN
cord-318495-1w74wf02	231	29	a	a	DT
cord-318495-1w74wf02	231	30	point	point	NN
cord-318495-1w74wf02	231	31	of	of	IN
cord-318495-1w74wf02	231	32	ineffectiveness	ineffectiveness	NN
cord-318495-1w74wf02	231	33	.	.	.
cord-318495-1w74wf02	232	1	While	while	IN
cord-318495-1w74wf02	232	2	recent	recent	JJ
cord-318495-1w74wf02	232	3	NGS	NGS	NNP
cord-318495-1w74wf02	232	4	data	datum	NNS
cord-318495-1w74wf02	232	5	reveal	reveal	VBP
cord-318495-1w74wf02	232	6	that	that	IN
cord-318495-1w74wf02	232	7	hundreds	hundred	NNS
cord-318495-1w74wf02	232	8	of	of	IN
cord-318495-1w74wf02	232	9	DVGs	dvg	NNS
cord-318495-1w74wf02	232	10	can	can	MD
cord-318495-1w74wf02	232	11	arise	arise	VB
cord-318495-1w74wf02	232	12	within	within	IN
cord-318495-1w74wf02	232	13	a	a	DT
cord-318495-1w74wf02	232	14	single	single	JJ
cord-318495-1w74wf02	232	15	viral	viral	JJ
cord-318495-1w74wf02	232	16	infection	infection	NN
cord-318495-1w74wf02	232	17	,	,	,
cord-318495-1w74wf02	232	18	the	the	DT
cord-318495-1w74wf02	232	19	fact	fact	NN
cord-318495-1w74wf02	232	20	that	that	IN
cord-318495-1w74wf02	232	21	a	a	DT
cord-318495-1w74wf02	232	22	smaller	small	JJR
cord-318495-1w74wf02	232	23	subset	subset	JJ
cord-318495-1w74wf02	232	24	of	of	IN
cord-318495-1w74wf02	232	25	dominant	dominant	JJ
cord-318495-1w74wf02	232	26	DVGs	dvg	NNS
cord-318495-1w74wf02	232	27	are	be	VBP
cord-318495-1w74wf02	232	28	repeatedly	repeatedly	RB
cord-318495-1w74wf02	232	29	detected	detect	VBN
cord-318495-1w74wf02	232	30	in	in	IN
cord-318495-1w74wf02	232	31	different	different	JJ
cord-318495-1w74wf02	232	32	samples	sample	NNS
cord-318495-1w74wf02	232	33	50	50	CD
cord-318495-1w74wf02	232	34	indicates	indicate	VBZ
cord-318495-1w74wf02	232	35	that	that	IN
cord-318495-1w74wf02	232	36	complex	complex	JJ
cord-318495-1w74wf02	232	37	dynamics	dynamic	NNS
cord-318495-1w74wf02	232	38	are	be	VBP
cord-318495-1w74wf02	232	39	at	at	IN
cord-318495-1w74wf02	232	40	play	play	NN
cord-318495-1w74wf02	232	41	within	within	IN
cord-318495-1w74wf02	232	42	the	the	DT
cord-318495-1w74wf02	232	43	viral	viral	JJ
cord-318495-1w74wf02	232	44	population	population	NN
cord-318495-1w74wf02	232	45	.	.	.
cord-318495-1w74wf02	233	1	These	these	DT
cord-318495-1w74wf02	233	2	complexities	complexity	NNS
cord-318495-1w74wf02	233	3	include	include	VBP
cord-318495-1w74wf02	233	4	competition	competition	NN
cord-318495-1w74wf02	233	5	(	(	-LRB-
cord-318495-1w74wf02	233	6	and	and	CC
cord-318495-1w74wf02	233	7	possibly	possibly	RB
cord-318495-1w74wf02	233	8	compensation	compensation	NN
cord-318495-1w74wf02	233	9	or	or	CC
cord-318495-1w74wf02	233	10	cooperation	cooperation	NN
cord-318495-1w74wf02	233	11	)	)	-RRB-
cord-318495-1w74wf02	233	12	between	between	IN
cord-318495-1w74wf02	233	13	different	different	JJ
cord-318495-1w74wf02	233	14	DVGs	dvg	NNS
cord-318495-1w74wf02	233	15	and	and	CC
cord-318495-1w74wf02	233	16	positive	positive	JJ
cord-318495-1w74wf02	233	17	selection	selection	NN
cord-318495-1w74wf02	233	18	of	of	IN
cord-318495-1w74wf02	233	19	the	the	DT
cord-318495-1w74wf02	233	20	best	good	JJS
cord-318495-1w74wf02	233	21	competitors	competitor	NNS
cord-318495-1w74wf02	233	22	that	that	WDT
cord-318495-1w74wf02	233	23	implicates	implicate	VBZ
cord-318495-1w74wf02	233	24	their	-PRON-	PRP$
cord-318495-1w74wf02	233	25	relative	relative	JJ
cord-318495-1w74wf02	233	26	fitness	fitness	NN
cord-318495-1w74wf02	233	27	in	in	IN
cord-318495-1w74wf02	233	28	relation	relation	NN
cord-318495-1w74wf02	233	29	to	to	IN
cord-318495-1w74wf02	233	30	the	the	DT
cord-318495-1w74wf02	233	31	wild	wild	JJ
cord-318495-1w74wf02	233	32	-	-	HYPH
cord-318495-1w74wf02	233	33	type	type	NN
cord-318495-1w74wf02	233	34	parental	parental	JJ
cord-318495-1w74wf02	233	35	virus	virus	NN
cord-318495-1w74wf02	233	36	and	and	CC
cord-318495-1w74wf02	233	37	other	other	JJ
cord-318495-1w74wf02	233	38	DVGs	dvg	NNS
cord-318495-1w74wf02	233	39	.	.	.
cord-318495-1w74wf02	234	1	Parameters	parameter	NNS
cord-318495-1w74wf02	234	2	such	such	JJ
cord-318495-1w74wf02	234	3	as	as	IN
cord-318495-1w74wf02	234	4	replication	replication	NN
cord-318495-1w74wf02	234	5	fitness	fitness	NN
cord-318495-1w74wf02	234	6	,	,	,
cord-318495-1w74wf02	234	7	packaging	packaging	NN
cord-318495-1w74wf02	234	8	,	,	,
cord-318495-1w74wf02	234	9	immunoregulation	immunoregulation	NN
cord-318495-1w74wf02	234	10	and	and	CC
cord-318495-1w74wf02	234	11	other	other	JJ
cord-318495-1w74wf02	234	12	traits	trait	NNS
cord-318495-1w74wf02	234	13	determine	determine	VBP
cord-318495-1w74wf02	234	14	the	the	DT
cord-318495-1w74wf02	234	15	virus	virus	NN
cord-318495-1w74wf02	234	16	dynamics	dynamic	NNS
cord-318495-1w74wf02	234	17	.	.	.
cord-318495-1w74wf02	235	1	It	-PRON-	PRP
cord-318495-1w74wf02	235	2	is	be	VBZ
cord-318495-1w74wf02	235	3	important	important	JJ
cord-318495-1w74wf02	235	4	to	to	TO
cord-318495-1w74wf02	235	5	stress	stress	VB
cord-318495-1w74wf02	235	6	that	that	IN
cord-318495-1w74wf02	235	7	most	most	JJS
cord-318495-1w74wf02	235	8	events	event	NNS
cord-318495-1w74wf02	235	9	leading	lead	VBG
cord-318495-1w74wf02	235	10	to	to	IN
cord-318495-1w74wf02	235	11	DVG	DVG	NNP
cord-318495-1w74wf02	235	12	formation	formation	NN
cord-318495-1w74wf02	235	13	,	,	,
cord-318495-1w74wf02	235	14	including	include	VBG
cord-318495-1w74wf02	235	15	mutations	mutation	NNS
cord-318495-1w74wf02	235	16	,	,	,
cord-318495-1w74wf02	235	17	deletions	deletion	NNS
cord-318495-1w74wf02	235	18	,	,	,
cord-318495-1w74wf02	235	19	recombination	recombination	NN
cord-318495-1w74wf02	235	20	and	and	CC
cord-318495-1w74wf02	235	21	translocations	translocation	NNS
cord-318495-1w74wf02	235	22	,	,	,
cord-318495-1w74wf02	235	23	are	be	VBP
cord-318495-1w74wf02	235	24	either	either	CC
cord-318495-1w74wf02	235	25	non	non	JJ
cord-318495-1w74wf02	235	26	-	-	JJ
cord-318495-1w74wf02	235	27	viable	viable	JJ
cord-318495-1w74wf02	235	28	or	or	CC
cord-318495-1w74wf02	235	29	deleterious	deleterious	JJ
cord-318495-1w74wf02	235	30	to	to	IN
cord-318495-1w74wf02	235	31	the	the	DT
cord-318495-1w74wf02	235	32	virus	virus	NN
cord-318495-1w74wf02	235	33	.	.	.
cord-318495-1w74wf02	236	1	In	in	IN
cord-318495-1w74wf02	236	2	addition	addition	NN
cord-318495-1w74wf02	236	3	,	,	,
cord-318495-1w74wf02	236	4	although	although	IN
cord-318495-1w74wf02	236	5	hundreds	hundred	NNS
cord-318495-1w74wf02	236	6	or	or	CC
cord-318495-1w74wf02	236	7	even	even	RB
cord-318495-1w74wf02	236	8	thousands	thousand	NNS
cord-318495-1w74wf02	236	9	of	of	IN
cord-318495-1w74wf02	236	10	different	different	JJ
cord-318495-1w74wf02	236	11	DVGs	dvg	NNS
cord-318495-1w74wf02	236	12	are	be	VBP
cord-318495-1w74wf02	236	13	generated	generate	VBN
cord-318495-1w74wf02	236	14	during	during	IN
cord-318495-1w74wf02	236	15	a	a	DT
cord-318495-1w74wf02	236	16	virus	virus	NN
cord-318495-1w74wf02	236	17	infection	infection	NN
cord-318495-1w74wf02	236	18	,	,	,
cord-318495-1w74wf02	236	19	the	the	DT
cord-318495-1w74wf02	236	20	vast	vast	JJ
cord-318495-1w74wf02	236	21	majority	majority	NN
cord-318495-1w74wf02	236	22	of	of	IN
cord-318495-1w74wf02	236	23	these	these	DT
cord-318495-1w74wf02	236	24	will	will	MD
cord-318495-1w74wf02	236	25	be	be	VB
cord-318495-1w74wf02	236	26	lost	lose	VBN
cord-318495-1w74wf02	236	27	during	during	IN
cord-318495-1w74wf02	236	28	the	the	DT
cord-318495-1w74wf02	236	29	population	population	NN
cord-318495-1w74wf02	236	30	bottlenecks	bottleneck	NNS
cord-318495-1w74wf02	236	31	that	that	WDT
cord-318495-1w74wf02	236	32	occur	occur	VBP
cord-318495-1w74wf02	236	33	in	in	IN
cord-318495-1w74wf02	236	34	vivo	vivo	NN
cord-318495-1w74wf02	236	35	,	,	,
cord-318495-1w74wf02	236	36	for	for	IN
cord-318495-1w74wf02	236	37	example	example	NN
cord-318495-1w74wf02	236	38	when	when	WRB
cord-318495-1w74wf02	236	39	crossing	cross	VBG
cord-318495-1w74wf02	236	40	anatomical	anatomical	JJ
cord-318495-1w74wf02	236	41	barriers	barrier	NNS
cord-318495-1w74wf02	236	42	or	or	CC
cord-318495-1w74wf02	236	43	during	during	IN
cord-318495-1w74wf02	236	44	transmission	transmission	NN
cord-318495-1w74wf02	236	45	from	from	IN
cord-318495-1w74wf02	236	46	host	host	NN
cord-318495-1w74wf02	236	47	to	to	TO
cord-318495-1w74wf02	236	48	host	host	VB
cord-318495-1w74wf02	236	49	127	127	CD
cord-318495-1w74wf02	236	50	.	.	.
cord-318495-1w74wf02	237	1	However	however	RB
cord-318495-1w74wf02	237	2	,	,	,
cord-318495-1w74wf02	237	3	there	there	EX
cord-318495-1w74wf02	237	4	are	be	VBP
cord-318495-1w74wf02	237	5	instances	instance	NNS
cord-318495-1w74wf02	237	6	where	where	WRB
cord-318495-1w74wf02	237	7	these	these	DT
cord-318495-1w74wf02	237	8	genomes	genome	NNS
cord-318495-1w74wf02	237	9	could	could	MD
cord-318495-1w74wf02	237	10	make	make	VB
cord-318495-1w74wf02	237	11	it	-PRON-	PRP
cord-318495-1w74wf02	237	12	through	through	IN
cord-318495-1w74wf02	237	13	bottlenecks	bottleneck	NNS
cord-318495-1w74wf02	237	14	,	,	,
cord-318495-1w74wf02	237	15	such	such	JJ
cord-318495-1w74wf02	237	16	as	as	IN
cord-318495-1w74wf02	237	17	during	during	IN
cord-318495-1w74wf02	237	18	infections	infection	NNS
cord-318495-1w74wf02	237	19	of	of	IN
cord-318495-1w74wf02	237	20	hosts	host	NNS
cord-318495-1w74wf02	237	21	that	that	WDT
cord-318495-1w74wf02	237	22	are	be	VBP
cord-318495-1w74wf02	237	23	immunosuppressed	immunosuppressed	JJ
cord-318495-1w74wf02	237	24	or	or	CC
cord-318495-1w74wf02	237	25	have	have	VBP
cord-318495-1w74wf02	237	26	comorbidities	comorbiditie	NNS
cord-318495-1w74wf02	237	27	where	where	WRB
cord-318495-1w74wf02	237	28	founding	founding	NN
cord-318495-1w74wf02	237	29	populations	population	NNS
cord-318495-1w74wf02	237	30	are	be	VBP
cord-318495-1w74wf02	237	31	increased	increase	VBN
cord-318495-1w74wf02	237	32	.	.	.
cord-318495-1w74wf02	238	1	In	in	IN
cord-318495-1w74wf02	238	2	addition	addition	NN
cord-318495-1w74wf02	238	3	,	,	,
cord-318495-1w74wf02	238	4	infections	infection	NNS
cord-318495-1w74wf02	238	5	may	may	MD
cord-318495-1w74wf02	238	6	occur	occur	VB
cord-318495-1w74wf02	238	7	with	with	IN
cord-318495-1w74wf02	238	8	virions	virion	NNS
cord-318495-1w74wf02	238	9	that	that	WDT
cord-318495-1w74wf02	238	10	have	have	VBP
cord-318495-1w74wf02	238	11	co	co	VBN
cord-318495-1w74wf02	238	12	-	-	VBN
cord-318495-1w74wf02	238	13	packaged	package	VBN
cord-318495-1w74wf02	238	14	wild	wild	JJ
cord-318495-1w74wf02	238	15	-	-	HYPH
cord-318495-1w74wf02	238	16	type	type	NN
cord-318495-1w74wf02	238	17	genomes	genome	NNS
cord-318495-1w74wf02	238	18	and	and	CC
cord-318495-1w74wf02	238	19	DVGs	dvg	NNS
cord-318495-1w74wf02	238	20	128	128	CD
cord-318495-1w74wf02	238	21	or	or	CC
cord-318495-1w74wf02	238	22	virions	virion	NNS
cord-318495-1w74wf02	238	23	may	may	MD
cord-318495-1w74wf02	238	24	aggregate	aggregate	VB
cord-318495-1w74wf02	238	25	during	during	IN
cord-318495-1w74wf02	238	26	infection	infection	NN
cord-318495-1w74wf02	238	27	enhancing	enhance	VBG
cord-318495-1w74wf02	238	28	co	co	NN
cord-318495-1w74wf02	238	29	-	-	NN
cord-318495-1w74wf02	238	30	transmission	transmission	NN
cord-318495-1w74wf02	238	31	,	,	,
cord-318495-1w74wf02	238	32	as	as	IN
cord-318495-1w74wf02	238	33	seen	see	VBN
cord-318495-1w74wf02	238	34	for	for	IN
cord-318495-1w74wf02	238	35	VSV	VSV	NNP
cord-318495-1w74wf02	238	36	129	129	CD
cord-318495-1w74wf02	238	37	mathematical	mathematical	JJ
cord-318495-1w74wf02	238	38	models	model	NNS
cord-318495-1w74wf02	238	39	have	have	VBP
cord-318495-1w74wf02	238	40	generally	generally	RB
cord-318495-1w74wf02	238	41	only	only	RB
cord-318495-1w74wf02	238	42	considered	consider	VBN
cord-318495-1w74wf02	238	43	one	one	CD
cord-318495-1w74wf02	238	44	dominant	dominant	JJ
cord-318495-1w74wf02	238	45	DVG	DVG	NNP
cord-318495-1w74wf02	238	46	131	131	CD
cord-318495-1w74wf02	238	47	,	,	,
cord-318495-1w74wf02	238	48	132	132	CD
cord-318495-1w74wf02	238	49	;	;	:
cord-318495-1w74wf02	238	50	further	further	JJ
cord-318495-1w74wf02	238	51	development	development	NN
cord-318495-1w74wf02	238	52	is	be	VBZ
cord-318495-1w74wf02	238	53	required	require	VBN
cord-318495-1w74wf02	238	54	to	to	TO
cord-318495-1w74wf02	238	55	incorporate	incorporate	VB
cord-318495-1w74wf02	238	56	the	the	DT
cord-318495-1w74wf02	238	57	potential	potential	JJ
cord-318495-1w74wf02	238	58	cooperation	cooperation	NN
cord-318495-1w74wf02	238	59	and	and	CC
cord-318495-1w74wf02	238	60	competition	competition	NN
cord-318495-1w74wf02	238	61	among	among	IN
cord-318495-1w74wf02	238	62	others	other	NNS
cord-318495-1w74wf02	238	63	.	.	.
cord-318495-1w74wf02	239	1	While	while	IN
cord-318495-1w74wf02	239	2	historically	historically	RB
cord-318495-1w74wf02	239	3	DVGs	dvg	NNS
cord-318495-1w74wf02	239	4	have	have	VBP
cord-318495-1w74wf02	239	5	been	be	VBN
cord-318495-1w74wf02	239	6	considered	consider	VBN
cord-318495-1w74wf02	239	7	replication	replication	NN
cord-318495-1w74wf02	239	8	waste	waste	NN
cord-318495-1w74wf02	239	9	,	,	,
cord-318495-1w74wf02	239	10	an	an	DT
cord-318495-1w74wf02	239	11	artifact	artifact	NN
cord-318495-1w74wf02	239	12	of	of	IN
cord-318495-1w74wf02	239	13	cell	cell	NN
cord-318495-1w74wf02	239	14	culture	culture	NN
cord-318495-1w74wf02	239	15	passaging	passaging	NN
cord-318495-1w74wf02	239	16	conditions	condition	NNS
cord-318495-1w74wf02	239	17	or	or	CC
cord-318495-1w74wf02	239	18	simply	simply	RB
cord-318495-1w74wf02	239	19	a	a	DT
cord-318495-1w74wf02	239	20	nuisance	nuisance	NN
cord-318495-1w74wf02	239	21	to	to	IN
cord-318495-1w74wf02	239	22	laboratory	laboratory	NN
cord-318495-1w74wf02	239	23	experimentation	experimentation	NN
cord-318495-1w74wf02	239	24	,	,	,
cord-318495-1w74wf02	239	25	a	a	DT
cord-318495-1w74wf02	239	26	renewed	renew	VBN
cord-318495-1w74wf02	239	27	interest	interest	NN
cord-318495-1w74wf02	239	28	in	in	IN
cord-318495-1w74wf02	239	29	this	this	DT
cord-318495-1w74wf02	239	30	part	part	NN
cord-318495-1w74wf02	239	31	of	of	IN
cord-318495-1w74wf02	239	32	the	the	DT
cord-318495-1w74wf02	239	33	viral	viral	JJ
cord-318495-1w74wf02	239	34	population	population	NN
cord-318495-1w74wf02	239	35	may	may	MD
cord-318495-1w74wf02	239	36	reveal	reveal	VB
cord-318495-1w74wf02	239	37	a	a	DT
cord-318495-1w74wf02	239	38	more	more	RBR
cord-318495-1w74wf02	239	39	functional	functional	JJ
cord-318495-1w74wf02	239	40	or	or	CC
cord-318495-1w74wf02	239	41	biological	biological	JJ
cord-318495-1w74wf02	239	42	relevance	relevance	NN
cord-318495-1w74wf02	239	43	to	to	IN
cord-318495-1w74wf02	239	44	their	-PRON-	PRP$
cord-318495-1w74wf02	239	45	existence	existence	NN
cord-318495-1w74wf02	239	46	.	.	.
cord-318495-1w74wf02	240	1	Do	do	VBP
cord-318495-1w74wf02	240	2	DVGs	dvg	NNS
cord-318495-1w74wf02	240	3	exist	exist	VB
cord-318495-1w74wf02	240	4	for	for	IN
cord-318495-1w74wf02	240	5	a	a	DT
cord-318495-1w74wf02	240	6	reason	reason	NN
cord-318495-1w74wf02	240	7	?	?	.
cord-318495-1w74wf02	241	1	Why	why	WRB
cord-318495-1w74wf02	241	2	keep	keep	VB
cord-318495-1w74wf02	241	3	waste	waste	NN
cord-318495-1w74wf02	241	4	lying	lie	VBG
cord-318495-1w74wf02	241	5	around	around	RB
cord-318495-1w74wf02	241	6	?	?	.
cord-318495-1w74wf02	242	1	Given	give	VBN
cord-318495-1w74wf02	242	2	the	the	DT
cord-318495-1w74wf02	242	3	notoriously	notoriously	RB
cord-318495-1w74wf02	242	4	high	high	JJ
cord-318495-1w74wf02	242	5	recombination	recombination	NN
cord-318495-1w74wf02	242	6	and	and	CC
cord-318495-1w74wf02	242	7	reassortment	reassortment	NN
cord-318495-1w74wf02	242	8	rates	rate	NNS
cord-318495-1w74wf02	242	9	of	of	IN
cord-318495-1w74wf02	242	10	some	some	DT
cord-318495-1w74wf02	242	11	viruses	virus	NNS
cord-318495-1w74wf02	242	12	,	,	,
cord-318495-1w74wf02	242	13	it	-PRON-	PRP
cord-318495-1w74wf02	242	14	is	be	VBZ
cord-318495-1w74wf02	242	15	possible	possible	JJ
cord-318495-1w74wf02	242	16	that	that	IN
cord-318495-1w74wf02	242	17	for	for	IN
cord-318495-1w74wf02	242	18	viruses	virus	NNS
cord-318495-1w74wf02	242	19	that	that	WDT
cord-318495-1w74wf02	242	20	undergo	undergo	VBP
cord-318495-1w74wf02	242	21	recombination	recombination	NN
cord-318495-1w74wf02	242	22	,	,	,
cord-318495-1w74wf02	242	23	DVGs	dvg	NNS
cord-318495-1w74wf02	242	24	can	can	MD
cord-318495-1w74wf02	242	25	provide	provide	VB
cord-318495-1w74wf02	242	26	a	a	DT
cord-318495-1w74wf02	242	27	repertoire	repertoire	NN
cord-318495-1w74wf02	242	28	of	of	IN
cord-318495-1w74wf02	242	29	mutations	mutation	NNS
cord-318495-1w74wf02	242	30	that	that	WDT
cord-318495-1w74wf02	242	31	could	could	MD
cord-318495-1w74wf02	242	32	feed	feed	VB
cord-318495-1w74wf02	242	33	back	back	RB
cord-318495-1w74wf02	242	34	into	into	IN
cord-318495-1w74wf02	242	35	the	the	DT
cord-318495-1w74wf02	242	36	viable	viable	JJ
cord-318495-1w74wf02	242	37	virus	virus	NN
cord-318495-1w74wf02	242	38	population	population	NN
cord-318495-1w74wf02	242	39	to	to	TO
cord-318495-1w74wf02	242	40	promote	promote	VB
cord-318495-1w74wf02	242	41	adaptation	adaptation	NN
cord-318495-1w74wf02	242	42	.	.	.
cord-318495-1w74wf02	243	1	It	-PRON-	PRP
cord-318495-1w74wf02	243	2	remains	remain	VBZ
cord-318495-1w74wf02	243	3	to	to	TO
cord-318495-1w74wf02	243	4	be	be	VB
cord-318495-1w74wf02	243	5	seen	see	VBN
cord-318495-1w74wf02	243	6	whether	whether	IN
cord-318495-1w74wf02	243	7	DVGs	dvg	NNS
cord-318495-1w74wf02	243	8	can	can	MD
cord-318495-1w74wf02	243	9	provide	provide	VB
cord-318495-1w74wf02	243	10	a	a	DT
cord-318495-1w74wf02	243	11	selective	selective	JJ
cord-318495-1w74wf02	243	12	advantage	advantage	NN
cord-318495-1w74wf02	243	13	to	to	IN
cord-318495-1w74wf02	243	14	the	the	DT
cord-318495-1w74wf02	243	15	virus	virus	NN
cord-318495-1w74wf02	243	16	,	,	,
cord-318495-1w74wf02	243	17	and	and	CC
cord-318495-1w74wf02	243	18	whether	whether	IN
cord-318495-1w74wf02	243	19	the	the	DT
cord-318495-1w74wf02	243	20	high	high	JJ
cord-318495-1w74wf02	243	21	MOI	MOI	NNP
cord-318495-1w74wf02	243	22	or	or	CC
cord-318495-1w74wf02	243	23	localized	localize	VBN
cord-318495-1w74wf02	243	24	co	co	NN
cord-318495-1w74wf02	243	25	-	-	NN
cord-318495-1w74wf02	243	26	infection	infection	JJ
cord-318495-1w74wf02	243	27	conditions	condition	NNS
cord-318495-1w74wf02	243	28	are	be	VBP
cord-318495-1w74wf02	243	29	biologically	biologically	RB
cord-318495-1w74wf02	243	30	relevant	relevant	JJ
cord-318495-1w74wf02	243	31	outside	outside	IN
cord-318495-1w74wf02	243	32	of	of	IN
cord-318495-1w74wf02	243	33	cell	cell	NN
cord-318495-1w74wf02	243	34	culture	culture	NN
cord-318495-1w74wf02	243	35	.	.	.
cord-318495-1w74wf02	244	1	Recent	recent	JJ
cord-318495-1w74wf02	244	2	work	work	NN
cord-318495-1w74wf02	244	3	in	in	IN
cord-318495-1w74wf02	244	4	insects	insect	NNS
cord-318495-1w74wf02	244	5	suggests	suggest	VBZ
cord-318495-1w74wf02	244	6	that	that	IN
cord-318495-1w74wf02	244	7	DVGs	dvg	NNS
cord-318495-1w74wf02	244	8	,	,	,
cord-318495-1w74wf02	244	9	which	which	WDT
cord-318495-1w74wf02	244	10	are	be	VBP
cord-318495-1w74wf02	244	11	a	a	DT
cord-318495-1w74wf02	244	12	preferred	preferred	JJ
cord-318495-1w74wf02	244	13	template	template	NN
cord-318495-1w74wf02	244	14	for	for	IN
cord-318495-1w74wf02	244	15	the	the	DT
cord-318495-1w74wf02	244	16	generation	generation	NN
cord-318495-1w74wf02	244	17	of	of	IN
cord-318495-1w74wf02	244	18	the	the	DT
cord-318495-1w74wf02	244	19	viral	viral	JJ
cord-318495-1w74wf02	244	20	DNA	dna	NN
cord-318495-1w74wf02	244	21	form	form	NN
cord-318495-1w74wf02	244	22	of	of	IN
cord-318495-1w74wf02	244	23	RNA	RNA	NNP
cord-318495-1w74wf02	244	24	viruses	virus	NNS
cord-318495-1w74wf02	244	25	,	,	,
cord-318495-1w74wf02	244	26	provide	provide	VB
cord-318495-1w74wf02	244	27	additional	additional	JJ
cord-318495-1w74wf02	244	28	substrate	substrate	NN
cord-318495-1w74wf02	244	29	to	to	TO
cord-318495-1w74wf02	244	30	help	help	VB
cord-318495-1w74wf02	244	31	boost	boost	VB
cord-318495-1w74wf02	244	32	the	the	DT
cord-318495-1w74wf02	244	33	RNA	RNA	NNP
cord-318495-1w74wf02	244	34	interference	interference	NN
cord-318495-1w74wf02	244	35	response	response	NN
cord-318495-1w74wf02	244	36	that	that	WDT
cord-318495-1w74wf02	244	37	is	be	VBZ
cord-318495-1w74wf02	244	38	responsible	responsible	JJ
cord-318495-1w74wf02	244	39	for	for	IN
cord-318495-1w74wf02	244	40	viral	viral	JJ
cord-318495-1w74wf02	244	41	persistence	persistence	NN
cord-318495-1w74wf02	244	42	in	in	IN
cord-318495-1w74wf02	244	43	insects	insect	NNS
cord-318495-1w74wf02	244	44	103	103	CD
cord-318495-1w74wf02	244	45	.	.	.
cord-318495-1w74wf02	245	1	Indeed	indeed	RB
cord-318495-1w74wf02	245	2	,	,	,
cord-318495-1w74wf02	245	3	it	-PRON-	PRP
cord-318495-1w74wf02	245	4	was	be	VBD
cord-318495-1w74wf02	245	5	shown	show	VBN
cord-318495-1w74wf02	245	6	that	that	IN
cord-318495-1w74wf02	245	7	a	a	DT
cord-318495-1w74wf02	245	8	change	change	NN
cord-318495-1w74wf02	245	9	in	in	IN
cord-318495-1w74wf02	245	10	the	the	DT
cord-318495-1w74wf02	245	11	amount	amount	NN
cord-318495-1w74wf02	245	12	of	of	IN
cord-318495-1w74wf02	245	13	viral	viral	JJ
cord-318495-1w74wf02	245	14	DNA	dna	NN
cord-318495-1w74wf02	245	15	generated	generate	VBN
cord-318495-1w74wf02	245	16	during	during	IN
cord-318495-1w74wf02	245	17	RNA	RNA	NNP
cord-318495-1w74wf02	245	18	virus	virus	NN
cord-318495-1w74wf02	245	19	infection	infection	NN
cord-318495-1w74wf02	245	20	in	in	IN
cord-318495-1w74wf02	245	21	Drosophila	Drosophila	NNP
cord-318495-1w74wf02	245	22	,	,	,
cord-318495-1w74wf02	245	23	altered	alter	VBD
cord-318495-1w74wf02	245	24	the	the	DT
cord-318495-1w74wf02	245	25	persistence	persistence	NN
cord-318495-1w74wf02	245	26	and	and	CC
cord-318495-1w74wf02	245	27	kinetics	kinetic	NNS
cord-318495-1w74wf02	245	28	of	of	IN
cord-318495-1w74wf02	245	29	a	a	DT
cord-318495-1w74wf02	245	30	wild	wild	JJ
cord-318495-1w74wf02	245	31	-	-	HYPH
cord-318495-1w74wf02	245	32	type	type	NN
cord-318495-1w74wf02	245	33	RNA	RNA	NNP
cord-318495-1w74wf02	245	34	virus	virus	NN
cord-318495-1w74wf02	245	35	infection	infection	NN
cord-318495-1w74wf02	245	36	.	.	.
cord-318495-1w74wf02	246	1	The	the	DT
cord-318495-1w74wf02	246	2	authors	author	NNS
cord-318495-1w74wf02	246	3	suggested	suggest	VBD
cord-318495-1w74wf02	246	4	that	that	IN
cord-318495-1w74wf02	246	5	evolution	evolution	NN
cord-318495-1w74wf02	246	6	has	have	VBZ
cord-318495-1w74wf02	246	7	perhaps	perhaps	RB
cord-318495-1w74wf02	246	8	fine	fine	RB
cord-318495-1w74wf02	246	9	-	-	HYPH
cord-318495-1w74wf02	246	10	tuned	tune	VBN
cord-318495-1w74wf02	246	11	the	the	DT
cord-318495-1w74wf02	246	12	production	production	NN
cord-318495-1w74wf02	246	13	of	of	IN
cord-318495-1w74wf02	246	14	DVGs	dvg	NNS
cord-318495-1w74wf02	246	15	to	to	TO
cord-318495-1w74wf02	246	16	balance	balance	VB
cord-318495-1w74wf02	246	17	wild	wild	JJ
cord-318495-1w74wf02	246	18	-	-	HYPH
cord-318495-1w74wf02	246	19	type	type	NN
cord-318495-1w74wf02	246	20	infection	infection	NN
cord-318495-1w74wf02	246	21	and	and	CC
cord-318495-1w74wf02	246	22	promote	promote	VB
cord-318495-1w74wf02	246	23	persistence	persistence	NN
cord-318495-1w74wf02	246	24	(	(	-LRB-
cord-318495-1w74wf02	246	25	and	and	CC
cord-318495-1w74wf02	246	26	ultimately	ultimately	RB
cord-318495-1w74wf02	246	27	,	,	,
cord-318495-1w74wf02	246	28	transmission	transmission	NN
cord-318495-1w74wf02	246	29	of	of	IN
cord-318495-1w74wf02	246	30	viruses	virus	NNS
cord-318495-1w74wf02	246	31	,	,	,
cord-318495-1w74wf02	246	32	including	include	VBG
cord-318495-1w74wf02	246	33	arboviruses	arbovirus	NNS
cord-318495-1w74wf02	246	34	in	in	IN
cord-318495-1w74wf02	246	35	mosquitoes	mosquito	NNS
cord-318495-1w74wf02	246	36	)	)	-RRB-
cord-318495-1w74wf02	246	37	.	.	.
cord-318495-1w74wf02	247	1	Additionally	additionally	RB
cord-318495-1w74wf02	247	2	,	,	,
cord-318495-1w74wf02	247	3	a	a	DT
cord-318495-1w74wf02	247	4	closer	close	JJR
cord-318495-1w74wf02	247	5	examination	examination	NN
cord-318495-1w74wf02	247	6	of	of	IN
cord-318495-1w74wf02	247	7	DVG	DVG	NNP
cord-318495-1w74wf02	247	8	dynamics	dynamic	NNS
cord-318495-1w74wf02	247	9	within	within	IN
cord-318495-1w74wf02	247	10	viral	viral	JJ
cord-318495-1w74wf02	247	11	populations	population	NNS
cord-318495-1w74wf02	247	12	can	can	MD
cord-318495-1w74wf02	247	13	help	help	VB
cord-318495-1w74wf02	247	14	better	well	RBR
cord-318495-1w74wf02	247	15	understand	understand	VB
cord-318495-1w74wf02	247	16	the	the	DT
cord-318495-1w74wf02	247	17	biology	biology	NN
cord-318495-1w74wf02	247	18	of	of	IN
cord-318495-1w74wf02	247	19	standard	standard	JJ
cord-318495-1w74wf02	247	20	viruses	virus	NNS
cord-318495-1w74wf02	247	21	.	.	.
cord-318495-1w74wf02	248	1	Indeed	indeed	RB
cord-318495-1w74wf02	248	2	,	,	,
cord-318495-1w74wf02	248	3	in	in	IN
cord-318495-1w74wf02	248	4	addition	addition	NN
cord-318495-1w74wf02	248	5	to	to	IN
cord-318495-1w74wf02	248	6	distinguishing	distinguish	VBG
cord-318495-1w74wf02	248	7	between	between	IN
cord-318495-1w74wf02	248	8	the	the	DT
cord-318495-1w74wf02	248	9	dispensable	dispensable	JJ
cord-318495-1w74wf02	248	10	and	and	CC
cord-318495-1w74wf02	248	11	indispensable	indispensable	JJ
cord-318495-1w74wf02	248	12	nucleotide	nucleotide	JJ
cord-318495-1w74wf02	248	13	sequences	sequence	NNS
cord-318495-1w74wf02	248	14	,	,	,
cord-318495-1w74wf02	248	15	proteins	protein	NNS
cord-318495-1w74wf02	248	16	and	and	CC
cord-318495-1w74wf02	248	17	RNA	RNA	NNP
cord-318495-1w74wf02	248	18	structures	structure	NNS
cord-318495-1w74wf02	248	19	,	,	,
cord-318495-1w74wf02	248	20	we	-PRON-	PRP
cord-318495-1w74wf02	248	21	can	can	MD
cord-318495-1w74wf02	248	22	identify	identify	VB
cord-318495-1w74wf02	248	23	what	what	WP
cord-318495-1w74wf02	248	24	viral	viral	JJ
cord-318495-1w74wf02	248	25	components	component	NNS
cord-318495-1w74wf02	248	26	can	can	MD
cord-318495-1w74wf02	248	27	operate	operate	VB
cord-318495-1w74wf02	248	28	in	in	IN
cord-318495-1w74wf02	248	29	cis	cis	NNP
cord-318495-1w74wf02	248	30	or	or	CC
cord-318495-1w74wf02	248	31	in	in	IN
cord-318495-1w74wf02	248	32	trans	trans	NNP
cord-318495-1w74wf02	248	33	.	.	.
cord-318495-1w74wf02	249	1	A	a	DT
cord-318495-1w74wf02	249	2	recent	recent	JJ
cord-318495-1w74wf02	249	3	study	study	NN
cord-318495-1w74wf02	249	4	of	of	IN
cord-318495-1w74wf02	249	5	HCV	HCV	NNP
cord-318495-1w74wf02	249	6	DVGs	dvg	NNS
cord-318495-1w74wf02	249	7	,	,	,
cord-318495-1w74wf02	249	8	for	for	IN
cord-318495-1w74wf02	249	9	example	example	NN
cord-318495-1w74wf02	249	10	,	,	,
cord-318495-1w74wf02	249	11	identified	identify	VBD
cord-318495-1w74wf02	249	12	novel	novel	JJ
cord-318495-1w74wf02	249	13	cis	cis	NNP
cord-318495-1w74wf02	249	14	-	-	HYPH
cord-318495-1w74wf02	249	15	acting	act	VBG
cord-318495-1w74wf02	249	16	RNA	RNA	NNP
cord-318495-1w74wf02	249	17	structures	structure	NNS
cord-318495-1w74wf02	249	18	that	that	WDT
cord-318495-1w74wf02	249	19	were	be	VBD
cord-318495-1w74wf02	249	20	required	require	VBN
cord-318495-1w74wf02	249	21	for	for	IN
cord-318495-1w74wf02	249	22	replication	replication	NN
cord-318495-1w74wf02	249	23	and	and	CC
cord-318495-1w74wf02	249	24	packaging	packaging	NN
cord-318495-1w74wf02	249	25	133	133	CD
cord-318495-1w74wf02	249	26	.	.	.
cord-318495-1w74wf02	250	1	Emerging	emerge	VBG
cord-318495-1w74wf02	250	2	technologies	technology	NNS
cord-318495-1w74wf02	250	3	that	that	WDT
cord-318495-1w74wf02	250	4	allow	allow	VBP
cord-318495-1w74wf02	250	5	the	the	DT
cord-318495-1w74wf02	250	6	identification	identification	NN
cord-318495-1w74wf02	250	7	of	of	IN
cord-318495-1w74wf02	250	8	defective	defective	JJ
cord-318495-1w74wf02	250	9	and	and	CC
cord-318495-1w74wf02	250	10	standard	standard	JJ
cord-318495-1w74wf02	250	11	viruses	virus	NNS
cord-318495-1w74wf02	250	12	in	in	IN
cord-318495-1w74wf02	250	13	natural	natural	JJ
cord-318495-1w74wf02	250	14	infections	infection	NNS
cord-318495-1w74wf02	250	15	,	,	,
cord-318495-1w74wf02	250	16	as	as	RB
cord-318495-1w74wf02	250	17	well	well	RB
cord-318495-1w74wf02	250	18	as	as	IN
cord-318495-1w74wf02	250	19	those	those	DT
cord-318495-1w74wf02	250	20	allowing	allow	VBG
cord-318495-1w74wf02	250	21	the	the	DT
cord-318495-1w74wf02	250	22	establishment	establishment	NN
cord-318495-1w74wf02	250	23	of	of	IN
cord-318495-1w74wf02	250	24	specific	specific	JJ
cord-318495-1w74wf02	250	25	associations	association	NNS
cord-318495-1w74wf02	250	26	of	of	IN
cord-318495-1w74wf02	250	27	DVGs	dvg	NNS
cord-318495-1w74wf02	250	28	with	with	IN
cord-318495-1w74wf02	250	29	functional	functional	JJ
cord-318495-1w74wf02	250	30	outcomes	outcome	NNS
cord-318495-1w74wf02	250	31	,	,	,
cord-318495-1w74wf02	250	32	have	have	VBP
cord-318495-1w74wf02	250	33	been	be	VBN
cord-318495-1w74wf02	250	34	crucial	crucial	JJ
cord-318495-1w74wf02	250	35	in	in	IN
cord-318495-1w74wf02	250	36	reviving	revive	VBG
cord-318495-1w74wf02	250	37	the	the	DT
cord-318495-1w74wf02	250	38	interest	interest	NN
cord-318495-1w74wf02	250	39	in	in	IN
cord-318495-1w74wf02	250	40	studying	study	VBG
cord-318495-1w74wf02	250	41	DVGs	dvg	NNS
cord-318495-1w74wf02	250	42	.	.	.
cord-318495-1w74wf02	251	1	Recent	recent	JJ
cord-318495-1w74wf02	251	2	work	work	NN
cord-318495-1w74wf02	251	3	has	have	VBZ
cord-318495-1w74wf02	251	4	provided	provide	VBN
cord-318495-1w74wf02	251	5	new	new	JJ
cord-318495-1w74wf02	251	6	appreciation	appreciation	NN
cord-318495-1w74wf02	251	7	for	for	IN
cord-318495-1w74wf02	251	8	DVG	DVG	NNP
cord-318495-1w74wf02	251	9	diversity	diversity	NN
cord-318495-1w74wf02	251	10	and	and	CC
cord-318495-1w74wf02	251	11	the	the	DT
cord-318495-1w74wf02	251	12	potentially	potentially	RB
cord-318495-1w74wf02	251	13	critical	critical	JJ
cord-318495-1w74wf02	251	14	role	role	NN
cord-318495-1w74wf02	251	15	of	of	IN
cord-318495-1w74wf02	251	16	DVGs	dvg	NNS
cord-318495-1w74wf02	251	17	in	in	IN
cord-318495-1w74wf02	251	18	defining	define	VBG
cord-318495-1w74wf02	251	19	the	the	DT
cord-318495-1w74wf02	251	20	clinical	clinical	JJ
cord-318495-1w74wf02	251	21	outcome	outcome	NN
cord-318495-1w74wf02	251	22	of	of	IN
cord-318495-1w74wf02	251	23	infections	infection	NNS
cord-318495-1w74wf02	251	24	;	;	:
cord-318495-1w74wf02	251	25	however	however	RB
cord-318495-1w74wf02	251	26	,	,	,
cord-318495-1w74wf02	251	27	a	a	DT
cord-318495-1w74wf02	251	28	number	number	NN
cord-318495-1w74wf02	251	29	of	of	IN
cord-318495-1w74wf02	251	30	questions	question	NNS
cord-318495-1w74wf02	251	31	remain	remain	VBP
cord-318495-1w74wf02	251	32	unanswered	unanswered	JJ
cord-318495-1w74wf02	251	33	:	:	:
cord-318495-1w74wf02	251	34	what	what	WP
cord-318495-1w74wf02	251	35	are	be	VBP
cord-318495-1w74wf02	251	36	the	the	DT
cord-318495-1w74wf02	251	37	molecular	molecular	JJ
cord-318495-1w74wf02	251	38	mechanisms	mechanism	NNS
cord-318495-1w74wf02	251	39	driving	drive	VBG
cord-318495-1w74wf02	251	40	the	the	DT
cord-318495-1w74wf02	251	41	generation	generation	NN
cord-318495-1w74wf02	251	42	of	of	IN
cord-318495-1w74wf02	251	43	DVGs	dvg	NNS
cord-318495-1w74wf02	251	44	?	?	.
cord-318495-1w74wf02	252	1	Can	Can	MD
cord-318495-1w74wf02	252	2	DVGs	dvg	NNS
cord-318495-1w74wf02	252	3	be	be	VB
cord-318495-1w74wf02	252	4	harnessed	harness	VBN
cord-318495-1w74wf02	252	5	for	for	IN
cord-318495-1w74wf02	252	6	the	the	DT
cord-318495-1w74wf02	252	7	control	control	NN
cord-318495-1w74wf02	252	8	of	of	IN
cord-318495-1w74wf02	252	9	virus	virus	NN
cord-318495-1w74wf02	252	10	pathogenesis	pathogenesis	NN
cord-318495-1w74wf02	252	11	and	and	CC
cord-318495-1w74wf02	252	12	spread	spread	VB
cord-318495-1w74wf02	252	13	?	?	.
cord-318495-1w74wf02	253	1	How	how	WRB
cord-318495-1w74wf02	253	2	do	do	VBP
cord-318495-1w74wf02	253	3	alterations	alteration	NNS
cord-318495-1w74wf02	253	4	in	in	IN
cord-318495-1w74wf02	253	5	the	the	DT
cord-318495-1w74wf02	253	6	DVG	DVG	NNP
cord-318495-1w74wf02	253	7	population	population	NN
cord-318495-1w74wf02	253	8	impact	impact	NN
cord-318495-1w74wf02	253	9	virus	virus	NN
cord-318495-1w74wf02	253	10	evolution	evolution	NN
cord-318495-1w74wf02	253	11	and	and	CC
cord-318495-1w74wf02	253	12	adaptation	adaptation	NN
cord-318495-1w74wf02	253	13	to	to	IN
cord-318495-1w74wf02	253	14	new	new	JJ
cord-318495-1w74wf02	253	15	hosts	host	NNS
cord-318495-1w74wf02	253	16	?	?	.
cord-318495-1w74wf02	254	1	How	how	WRB
cord-318495-1w74wf02	254	2	do	do	VBP
cord-318495-1w74wf02	254	3	host	host	NN
cord-318495-1w74wf02	254	4	factors	factor	NNS
cord-318495-1w74wf02	254	5	impact	impact	VBP
cord-318495-1w74wf02	254	6	DVG	DVG	NNP
cord-318495-1w74wf02	254	7	accumulation	accumulation	NN
cord-318495-1w74wf02	254	8	and	and	CC
cord-318495-1w74wf02	254	9	activity	activity	NN
cord-318495-1w74wf02	254	10	?	?	.
cord-318495-1w74wf02	255	1	Further	further	JJ
cord-318495-1w74wf02	255	2	technological	technological	JJ
cord-318495-1w74wf02	255	3	developments	development	NNS
cord-318495-1w74wf02	255	4	and	and	CC
cord-318495-1w74wf02	255	5	interdisciplinary	interdisciplinary	JJ
cord-318495-1w74wf02	255	6	research	research	NN
cord-318495-1w74wf02	255	7	will	will	MD
cord-318495-1w74wf02	255	8	be	be	VB
cord-318495-1w74wf02	255	9	required	require	VBN
cord-318495-1w74wf02	255	10	to	to	TO
cord-318495-1w74wf02	255	11	obtain	obtain	VB
cord-318495-1w74wf02	255	12	these	these	DT
cord-318495-1w74wf02	255	13	answers	answer	NNS
cord-318495-1w74wf02	255	14	.	.	.
cord-318495-1w74wf02	256	1	Virus	virus	NN
cord-318495-1w74wf02	256	2	population	population	NN
cord-318495-1w74wf02	256	3	dynamics	dynamic	NNS
cord-318495-1w74wf02	256	4	during	during	IN
cord-318495-1w74wf02	256	5	infection	infection	NN
cord-318495-1w74wf02	256	6	Studies	Studies	NNPS
cord-318495-1w74wf02	256	7	on	on	IN
cord-318495-1w74wf02	256	8	interference	interference	NN
cord-318495-1w74wf02	256	9	in	in	IN
cord-318495-1w74wf02	256	10	experimental	experimental	JJ
cord-318495-1w74wf02	256	11	influenza	influenza	NN
cord-318495-1w74wf02	256	12	Defective	defective	JJ
cord-318495-1w74wf02	256	13	viral	viral	JJ
cord-318495-1w74wf02	256	14	particles	particle	NNS
cord-318495-1w74wf02	256	15	and	and	CC
cord-318495-1w74wf02	256	16	viral	viral	JJ
cord-318495-1w74wf02	256	17	disease	disease	NN
cord-318495-1w74wf02	256	18	processes	process	VBZ
cord-318495-1w74wf02	256	19	Modulation	Modulation	NNP
cord-318495-1w74wf02	256	20	of	of	IN
cord-318495-1w74wf02	256	21	Semliki	Semliki	NNP
cord-318495-1w74wf02	256	22	Forest	Forest	NNP
cord-318495-1w74wf02	256	23	virusinduced	virusinduce	VBD
cord-318495-1w74wf02	256	24	infection	infection	NN
cord-318495-1w74wf02	256	25	of	of	IN
cord-318495-1w74wf02	256	26	mice	mouse	NNS
cord-318495-1w74wf02	256	27	by	by	IN
cord-318495-1w74wf02	256	28	defective	defective	JJ
cord-318495-1w74wf02	256	29	-	-	HYPH
cord-318495-1w74wf02	256	30	interfering	interfere	VBG
cord-318495-1w74wf02	256	31	virus	virus	NN
cord-318495-1w74wf02	257	1	The	the	DT
cord-318495-1w74wf02	257	2	influence	influence	NN
cord-318495-1w74wf02	257	3	of	of	IN
cord-318495-1w74wf02	257	4	defective	defective	JJ
cord-318495-1w74wf02	257	5	-	-	HYPH
cord-318495-1w74wf02	257	6	interfering	interfere	VBG
cord-318495-1w74wf02	257	7	particles	particle	NNS
cord-318495-1w74wf02	257	8	of	of	IN
cord-318495-1w74wf02	257	9	the	the	DT
cord-318495-1w74wf02	257	10	PR-8	PR-8	NNP
cord-318495-1w74wf02	257	11	strain	strain	NN
cord-318495-1w74wf02	257	12	of	of	IN
cord-318495-1w74wf02	257	13	influenza	influenza	NN
cord-318495-1w74wf02	257	14	A	a	DT
cord-318495-1w74wf02	257	15	virus	virus	NN
cord-318495-1w74wf02	257	16	on	on	IN
cord-318495-1w74wf02	257	17	the	the	DT
cord-318495-1w74wf02	257	18	pathogenesis	pathogenesis	NN
cord-318495-1w74wf02	257	19	of	of	IN
cord-318495-1w74wf02	257	20	pulmonary	pulmonary	JJ
cord-318495-1w74wf02	257	21	infection	infection	NN
cord-318495-1w74wf02	257	22	in	in	IN
cord-318495-1w74wf02	257	23	mice	mouse	NNS
cord-318495-1w74wf02	258	1	Sindbis	Sindbis	NNP
cord-318495-1w74wf02	258	2	virus	virus	NN
cord-318495-1w74wf02	258	3	:	:	:
cord-318495-1w74wf02	259	1	early	early	JJ
cord-318495-1w74wf02	259	2	passage	passage	NN
cord-318495-1w74wf02	259	3	defective	defective	JJ
cord-318495-1w74wf02	259	4	-	-	HYPH
cord-318495-1w74wf02	259	5	interfering	interfere	VBG
cord-318495-1w74wf02	259	6	particles	particle	NNS
cord-318495-1w74wf02	259	7	induce	induce	VB
cord-318495-1w74wf02	259	8	interferon	interferon	NN
cord-318495-1w74wf02	260	1	The	the	DT
cord-318495-1w74wf02	260	2	characteristics	characteristic	NNS
cord-318495-1w74wf02	260	3	required	require	VBN
cord-318495-1w74wf02	260	4	for	for	IN
cord-318495-1w74wf02	260	5	a	a	DT
cord-318495-1w74wf02	260	6	Sendai	Sendai	NNP
cord-318495-1w74wf02	260	7	virus	virus	NN
cord-318495-1w74wf02	260	8	preparation	preparation	NN
cord-318495-1w74wf02	260	9	to	to	TO
cord-318495-1w74wf02	260	10	induce	induce	VB
cord-318495-1w74wf02	260	11	high	high	JJ
cord-318495-1w74wf02	260	12	levels	level	NNS
cord-318495-1w74wf02	260	13	of	of	IN
cord-318495-1w74wf02	260	14	interferon	interferon	NN
cord-318495-1w74wf02	260	15	in	in	IN
cord-318495-1w74wf02	260	16	human	human	JJ
cord-318495-1w74wf02	260	17	lymphoblastoid	lymphoblastoid	NN
cord-318495-1w74wf02	260	18	cells	cell	NNS
cord-318495-1w74wf02	260	19	Defective	defective	JJ
cord-318495-1w74wf02	260	20	interfering	interfere	VBG
cord-318495-1w74wf02	260	21	particles	particle	NNS
cord-318495-1w74wf02	260	22	with	with	IN
cord-318495-1w74wf02	260	23	covalently	covalently	RB
cord-318495-1w74wf02	260	24	linked	link	VBN
cord-318495-1w74wf02	260	25	[	[	-LRB-
cord-318495-1w74wf02	260	26	±]RNA	±]RNA	NNP
cord-318495-1w74wf02	260	27	induce	induce	VB
cord-318495-1w74wf02	260	28	interferon	interferon	NN
cord-318495-1w74wf02	260	29	Chronic	Chronic	NNP
cord-318495-1w74wf02	260	30	non	non	JJ
cord-318495-1w74wf02	260	31	-	-	JJ
cord-318495-1w74wf02	260	32	cytopathic	cytopathic	JJ
cord-318495-1w74wf02	260	33	infection	infection	NN
cord-318495-1w74wf02	260	34	of	of	IN
cord-318495-1w74wf02	260	35	human	human	JJ
cord-318495-1w74wf02	260	36	continuous	continuous	JJ
cord-318495-1w74wf02	260	37	cell	cell	NN
cord-318495-1w74wf02	260	38	lines	line	NNS
cord-318495-1w74wf02	260	39	with	with	IN
cord-318495-1w74wf02	260	40	mumps	mumps	NN
cord-318495-1w74wf02	260	41	virus	virus	NN
cord-318495-1w74wf02	260	42	Defective	defective	JJ
cord-318495-1w74wf02	260	43	interfering	interfere	VBG
cord-318495-1w74wf02	260	44	influenza	influenza	NN
cord-318495-1w74wf02	260	45	viruses	virus	NNS
cord-318495-1w74wf02	260	46	and	and	CC
cord-318495-1w74wf02	260	47	host	host	NN
cord-318495-1w74wf02	260	48	cells	cell	NNS
cord-318495-1w74wf02	260	49	:	:	:
cord-318495-1w74wf02	260	50	establishment	establishment	NN
cord-318495-1w74wf02	260	51	and	and	CC
cord-318495-1w74wf02	260	52	maintenance	maintenance	NN
cord-318495-1w74wf02	260	53	of	of	IN
cord-318495-1w74wf02	260	54	persistent	persistent	JJ
cord-318495-1w74wf02	260	55	influenza	influenza	NN
cord-318495-1w74wf02	260	56	virus	virus	NN
cord-318495-1w74wf02	260	57	infection	infection	NN
cord-318495-1w74wf02	260	58	in	in	IN
cord-318495-1w74wf02	260	59	MDBK	MDBK	NNP
cord-318495-1w74wf02	260	60	and	and	CC
cord-318495-1w74wf02	260	61	HeLa	HeLa	NNP
cord-318495-1w74wf02	260	62	cells	cell	NNS
cord-318495-1w74wf02	261	1	Characterization	characterization	NN
cord-318495-1w74wf02	261	2	of	of	IN
cord-318495-1w74wf02	261	3	rabies	rabies	NN
cord-318495-1w74wf02	261	4	viruses	virus	NNS
cord-318495-1w74wf02	261	5	recovered	recover	VBN
cord-318495-1w74wf02	261	6	from	from	IN
cord-318495-1w74wf02	261	7	persistently	persistently	RB
cord-318495-1w74wf02	261	8	infected	infect	VBN
cord-318495-1w74wf02	261	9	BHK	BHK	NNP
cord-318495-1w74wf02	261	10	cells	cell	NNS
cord-318495-1w74wf02	261	11	Persistent	persistent	JJ
cord-318495-1w74wf02	261	12	infection	infection	NN
cord-318495-1w74wf02	261	13	with	with	IN
cord-318495-1w74wf02	261	14	infectious	infectious	JJ
cord-318495-1w74wf02	261	15	pancreatic	pancreatic	JJ
cord-318495-1w74wf02	261	16	necrosis	necrosis	NN
cord-318495-1w74wf02	261	17	virus	virus	NN
cord-318495-1w74wf02	261	18	mediated	mediate	VBN
cord-318495-1w74wf02	261	19	by	by	IN
cord-318495-1w74wf02	261	20	defective	defective	JJ
cord-318495-1w74wf02	261	21	-	-	HYPH
cord-318495-1w74wf02	261	22	interfering	interfere	VBG
cord-318495-1w74wf02	261	23	(	(	-LRB-
cord-318495-1w74wf02	261	24	DI	DI	NNP
cord-318495-1w74wf02	261	25	)	)	-RRB-
cord-318495-1w74wf02	261	26	virus	virus	NN
cord-318495-1w74wf02	261	27	particles	particle	NNS
cord-318495-1w74wf02	261	28	in	in	IN
cord-318495-1w74wf02	261	29	a	a	DT
cord-318495-1w74wf02	261	30	cell	cell	NN
cord-318495-1w74wf02	261	31	line	line	NN
cord-318495-1w74wf02	261	32	showing	show	VBG
cord-318495-1w74wf02	261	33	strong	strong	JJ
cord-318495-1w74wf02	261	34	interference	interference	NN
cord-318495-1w74wf02	261	35	but	but	CC
cord-318495-1w74wf02	261	36	little	little	JJ
cord-318495-1w74wf02	261	37	DI	DI	NNP
cord-318495-1w74wf02	261	38	replication	replication	NN
cord-318495-1w74wf02	262	1	A	a	DT
cord-318495-1w74wf02	262	2	persistent	persistent	JJ
cord-318495-1w74wf02	262	3	and	and	CC
cord-318495-1w74wf02	262	4	inapparent	inapparent	JJ
cord-318495-1w74wf02	262	5	infection	infection	NN
cord-318495-1w74wf02	262	6	of	of	IN
cord-318495-1w74wf02	262	7	L	l	NN
cord-318495-1w74wf02	262	8	cells	cell	NNS
cord-318495-1w74wf02	262	9	with	with	IN
cord-318495-1w74wf02	262	10	the	the	DT
cord-318495-1w74wf02	262	11	virus	virus	NN
cord-318495-1w74wf02	262	12	of	of	IN
cord-318495-1w74wf02	262	13	lymphocytic	lymphocytic	JJ
cord-318495-1w74wf02	262	14	choriomeningitis	choriomeningitis	NNP
cord-318495-1w74wf02	262	15	Establishment	Establishment	NNP
cord-318495-1w74wf02	262	16	of	of	IN
cord-318495-1w74wf02	262	17	Sendai	Sendai	NNP
cord-318495-1w74wf02	262	18	virus	virus	NN
cord-318495-1w74wf02	262	19	persistent	persistent	JJ
cord-318495-1w74wf02	262	20	infection	infection	NN
cord-318495-1w74wf02	262	21	:	:	:
cord-318495-1w74wf02	262	22	biochemical	biochemical	JJ
cord-318495-1w74wf02	262	23	analysis	analysis	NN
cord-318495-1w74wf02	262	24	of	of	IN
cord-318495-1w74wf02	262	25	the	the	DT
cord-318495-1w74wf02	262	26	early	early	JJ
cord-318495-1w74wf02	262	27	phase	phase	NN
cord-318495-1w74wf02	262	28	of	of	IN
cord-318495-1w74wf02	262	29	a	a	DT
cord-318495-1w74wf02	262	30	standard	standard	JJ
cord-318495-1w74wf02	262	31	plus	plus	CC
cord-318495-1w74wf02	262	32	defective	defective	JJ
cord-318495-1w74wf02	262	33	interfering	interfere	VBG
cord-318495-1w74wf02	262	34	virus	virus	NN
cord-318495-1w74wf02	262	35	infection	infection	NN
cord-318495-1w74wf02	262	36	of	of	IN
cord-318495-1w74wf02	262	37	BHK	BHK	NNP
cord-318495-1w74wf02	262	38	cells	cell	NNS
cord-318495-1w74wf02	262	39	Persistent	persistent	JJ
cord-318495-1w74wf02	262	40	infection	infection	NN
cord-318495-1w74wf02	262	41	of	of	IN
cord-318495-1w74wf02	262	42	cultured	cultured	JJ
cord-318495-1w74wf02	262	43	mammalian	mammalian	JJ
cord-318495-1w74wf02	262	44	cells	cell	NNS
cord-318495-1w74wf02	262	45	by	by	IN
cord-318495-1w74wf02	262	46	Japanese	japanese	JJ
cord-318495-1w74wf02	262	47	encephalitis	encephalitis	RB
cord-318495-1w74wf02	262	48	virus	virus	NN
cord-318495-1w74wf02	262	49	Persistent	persistent	JJ
cord-318495-1w74wf02	262	50	infection	infection	NN
cord-318495-1w74wf02	262	51	.	.	.
cord-318495-1w74wf02	263	1	I	-PRON-	PRP
cord-318495-1w74wf02	263	2	Interferon	Interferon	NNP
cord-318495-1w74wf02	263	3	-	-	HYPH
cord-318495-1w74wf02	263	4	inducing	induce	VBG
cord-318495-1w74wf02	263	5	defective	defective	JJ
cord-318495-1w74wf02	263	6	-	-	HYPH
cord-318495-1w74wf02	263	7	interfering	interfere	VBG
cord-318495-1w74wf02	263	8	particles	particle	NNS
cord-318495-1w74wf02	263	9	as	as	IN
cord-318495-1w74wf02	263	10	mediators	mediator	NNS
cord-318495-1w74wf02	263	11	of	of	IN
cord-318495-1w74wf02	263	12	cell	cell	NN
cord-318495-1w74wf02	263	13	sparing	sparing	NN
cord-318495-1w74wf02	263	14	:	:	:
cord-318495-1w74wf02	263	15	possible	possible	JJ
cord-318495-1w74wf02	263	16	role	role	NN
cord-318495-1w74wf02	263	17	in	in	IN
cord-318495-1w74wf02	263	18	persistent	persistent	JJ
cord-318495-1w74wf02	263	19	infection	infection	NN
cord-318495-1w74wf02	263	20	by	by	IN
cord-318495-1w74wf02	263	21	vesicular	vesicular	JJ
cord-318495-1w74wf02	263	22	stomatitis	stomatitis	NN
cord-318495-1w74wf02	263	23	virus	virus	NN
cord-318495-1w74wf02	263	24	Expression	expression	NN
cord-318495-1w74wf02	263	25	of	of	IN
cord-318495-1w74wf02	263	26	defective	defective	JJ
cord-318495-1w74wf02	263	27	measles	measle	NNS
cord-318495-1w74wf02	263	28	virus	virus	NN
cord-318495-1w74wf02	263	29	genes	gene	NNS
cord-318495-1w74wf02	263	30	in	in	IN
cord-318495-1w74wf02	263	31	brain	brain	NN
cord-318495-1w74wf02	263	32	tissues	tissue	NNS
cord-318495-1w74wf02	263	33	of	of	IN
cord-318495-1w74wf02	263	34	patients	patient	NNS
cord-318495-1w74wf02	263	35	with	with	IN
cord-318495-1w74wf02	263	36	subacute	subacute	JJ
cord-318495-1w74wf02	263	37	sclerosing	sclerosing	NN
cord-318495-1w74wf02	263	38	panencephalitis	panencephalitis	NN
cord-318495-1w74wf02	263	39	Defective	defective	JJ
cord-318495-1w74wf02	263	40	interfering	interfere	VBG
cord-318495-1w74wf02	263	41	particles	particle	NNS
cord-318495-1w74wf02	263	42	in	in	IN
cord-318495-1w74wf02	263	43	mice	mouse	NNS
cord-318495-1w74wf02	263	44	infected	infect	VBN
cord-318495-1w74wf02	263	45	with	with	IN
cord-318495-1w74wf02	263	46	lymphocytic	lymphocytic	JJ
cord-318495-1w74wf02	263	47	choriomeningitis	choriomeningitis	NNP
cord-318495-1w74wf02	263	48	virus	virus	NN
cord-318495-1w74wf02	263	49	Rift	Rift	NNP
cord-318495-1w74wf02	263	50	Valley	Valley	NNP
cord-318495-1w74wf02	263	51	Fever	Fever	NNP
cord-318495-1w74wf02	263	52	virus	virus	NN
cord-318495-1w74wf02	263	53	in	in	IN
cord-318495-1w74wf02	263	54	mice	mouse	NNS
cord-318495-1w74wf02	263	55	.	.	.
cord-318495-1w74wf02	264	1	IV	IV	NNP
cord-318495-1w74wf02	264	2	.	.	.
cord-318495-1w74wf02	265	1	Incomplete	incomplete	JJ
cord-318495-1w74wf02	265	2	virus	virus	NN
cord-318495-1w74wf02	265	3	;	;	:
cord-318495-1w74wf02	266	1	its	-PRON-	PRP$
cord-318495-1w74wf02	266	2	production	production	NN
cord-318495-1w74wf02	266	3	and	and	CC
cord-318495-1w74wf02	266	4	properties	property	NNS
cord-318495-1w74wf02	266	5	Persistent	persistent	JJ
cord-318495-1w74wf02	266	6	measles	measle	NNS
cord-318495-1w74wf02	266	7	virus	virus	NN
cord-318495-1w74wf02	266	8	infection	infection	NN
cord-318495-1w74wf02	266	9	in	in	IN
cord-318495-1w74wf02	266	10	vitro	vitro	FW
cord-318495-1w74wf02	266	11	and	and	CC
cord-318495-1w74wf02	266	12	in	in	IN
cord-318495-1w74wf02	266	13	man	man	NN
cord-318495-1w74wf02	266	14	Defective	defective	JJ
cord-318495-1w74wf02	266	15	T	T	NNP
cord-318495-1w74wf02	266	16	particles	particle	NNS
cord-318495-1w74wf02	266	17	of	of	IN
cord-318495-1w74wf02	266	18	vesicular	vesicular	JJ
cord-318495-1w74wf02	266	19	stomatitis	stomatitis	NN
cord-318495-1w74wf02	266	20	virus	virus	NN
cord-318495-1w74wf02	266	21	.	.	.
cord-318495-1w74wf02	267	1	I.	I.	NNP
cord-318495-1w74wf02	267	2	Preparation	preparation	NN
cord-318495-1w74wf02	267	3	,	,	,
cord-318495-1w74wf02	267	4	morphology	morphology	NN
cord-318495-1w74wf02	267	5	,	,	,
cord-318495-1w74wf02	267	6	and	and	CC
cord-318495-1w74wf02	267	7	some	some	DT
cord-318495-1w74wf02	267	8	biologic	biologic	JJ
cord-318495-1w74wf02	267	9	properties	property	NNS
cord-318495-1w74wf02	268	1	The	the	DT
cord-318495-1w74wf02	268	2	RNA	RNA	NNP
cord-318495-1w74wf02	268	3	of	of	IN
cord-318495-1w74wf02	268	4	influenza	influenza	NN
cord-318495-1w74wf02	268	5	virus	virus	NN
cord-318495-1w74wf02	268	6	Properties	property	NNS
cord-318495-1w74wf02	268	7	of	of	IN
cord-318495-1w74wf02	268	8	incomplete	incomplete	JJ
cord-318495-1w74wf02	268	9	Sendai	Sendai	NNP
cord-318495-1w74wf02	268	10	virions	virion	NNS
cord-318495-1w74wf02	268	11	and	and	CC
cord-318495-1w74wf02	268	12	subgenomic	subgenomic	JJ
cord-318495-1w74wf02	268	13	viral	viral	JJ
cord-318495-1w74wf02	268	14	RNAs	rna	NNS
cord-318495-1w74wf02	268	15	Defective	defective	JJ
cord-318495-1w74wf02	268	16	interfering	interfere	VBG
cord-318495-1w74wf02	268	17	particles	particle	NNS
cord-318495-1w74wf02	268	18	of	of	IN
cord-318495-1w74wf02	268	19	poliovirus	poliovirus	NN
cord-318495-1w74wf02	268	20	.	.	.
cord-318495-1w74wf02	269	1	I.	I.	NNP
cord-318495-1w74wf02	269	2	Isolation	isolation	NN
cord-318495-1w74wf02	269	3	and	and	CC
cord-318495-1w74wf02	269	4	physical	physical	JJ
cord-318495-1w74wf02	269	5	properties	property	NNS
cord-318495-1w74wf02	269	6	Determination	determination	NN
cord-318495-1w74wf02	269	7	of	of	IN
cord-318495-1w74wf02	269	8	the	the	DT
cord-318495-1w74wf02	269	9	molecular	molecular	JJ
cord-318495-1w74wf02	269	10	weight	weight	NN
cord-318495-1w74wf02	269	11	of	of	IN
cord-318495-1w74wf02	269	12	animal	animal	NN
cord-318495-1w74wf02	269	13	RNA	rna	NN
cord-318495-1w74wf02	269	14	viral	viral	JJ
cord-318495-1w74wf02	269	15	genomes	genome	NNS
cord-318495-1w74wf02	269	16	by	by	IN
cord-318495-1w74wf02	269	17	nuclease	nuclease	NN
cord-318495-1w74wf02	269	18	digestions	digestion	NNS
cord-318495-1w74wf02	269	19	.	.	.
cord-318495-1w74wf02	270	1	I.	I.	NNP
cord-318495-1w74wf02	270	2	Vesicular	Vesicular	NNP
cord-318495-1w74wf02	270	3	stomatitis	stomatitis	NN
cord-318495-1w74wf02	270	4	virus	virus	NN
cord-318495-1w74wf02	270	5	and	and	CC
cord-318495-1w74wf02	270	6	its	-PRON-	PRP$
cord-318495-1w74wf02	270	7	defective	defective	JJ
cord-318495-1w74wf02	270	8	T	t	NN
cord-318495-1w74wf02	270	9	particle	particle	NN
cord-318495-1w74wf02	271	1	The	the	DT
cord-318495-1w74wf02	271	2	distribution	distribution	NN
cord-318495-1w74wf02	271	3	of	of	IN
cord-318495-1w74wf02	271	4	fitness	fitness	NN
cord-318495-1w74wf02	271	5	effects	effect	NNS
cord-318495-1w74wf02	271	6	caused	cause	VBN
cord-318495-1w74wf02	271	7	by	by	IN
cord-318495-1w74wf02	271	8	single	single	JJ
cord-318495-1w74wf02	271	9	-	-	HYPH
cord-318495-1w74wf02	271	10	nucleotide	nucleotide	NN
cord-318495-1w74wf02	271	11	substitutions	substitution	NNS
cord-318495-1w74wf02	271	12	in	in	IN
cord-318495-1w74wf02	271	13	an	an	DT
cord-318495-1w74wf02	271	14	RNA	RNA	NNP
cord-318495-1w74wf02	271	15	virus	virus	NN
cord-318495-1w74wf02	271	16	Mutational	Mutational	NNP
cord-318495-1w74wf02	271	17	and	and	CC
cord-318495-1w74wf02	271	18	fitness	fitness	NN
cord-318495-1w74wf02	271	19	landscapes	landscape	NNS
cord-318495-1w74wf02	271	20	of	of	IN
cord-318495-1w74wf02	271	21	an	an	DT
cord-318495-1w74wf02	271	22	RNA	RNA	NNP
cord-318495-1w74wf02	271	23	virus	virus	NN
cord-318495-1w74wf02	271	24	revealed	reveal	VBD
cord-318495-1w74wf02	271	25	through	through	IN
cord-318495-1w74wf02	271	26	population	population	NN
cord-318495-1w74wf02	271	27	sequencing	sequence	VBG
cord-318495-1w74wf02	271	28	The	the	DT
cord-318495-1w74wf02	271	29	inherent	inherent	JJ
cord-318495-1w74wf02	271	30	mutational	mutational	JJ
cord-318495-1w74wf02	271	31	tolerance	tolerance	NN
cord-318495-1w74wf02	271	32	and	and	CC
cord-318495-1w74wf02	271	33	antigenic	antigenic	JJ
cord-318495-1w74wf02	271	34	evolvability	evolvability	NN
cord-318495-1w74wf02	271	35	of	of	IN
cord-318495-1w74wf02	271	36	influenza	influenza	NN
cord-318495-1w74wf02	271	37	hemagglutinin	hemagglutinin	NN
cord-318495-1w74wf02	271	38	Insights	Insights	NNPS
cord-318495-1w74wf02	271	39	into	into	IN
cord-318495-1w74wf02	271	40	RNA	RNA	NNP
cord-318495-1w74wf02	271	41	virus	virus	NN
cord-318495-1w74wf02	271	42	mutant	mutant	JJ
cord-318495-1w74wf02	271	43	spectrum	spectrum	NN
cord-318495-1w74wf02	271	44	and	and	CC
cord-318495-1w74wf02	271	45	lethal	lethal	JJ
cord-318495-1w74wf02	271	46	mutagenesis	mutagenesis	NN
cord-318495-1w74wf02	271	47	events	event	NNS
cord-318495-1w74wf02	271	48	:	:	:
cord-318495-1w74wf02	271	49	replicative	replicative	JJ
cord-318495-1w74wf02	271	50	interference	interference	NN
cord-318495-1w74wf02	271	51	and	and	CC
cord-318495-1w74wf02	271	52	complementation	complementation	NN
cord-318495-1w74wf02	271	53	by	by	IN
cord-318495-1w74wf02	271	54	multiple	multiple	JJ
cord-318495-1w74wf02	271	55	point	point	NN
cord-318495-1w74wf02	271	56	mutants	mutant	NNS
cord-318495-1w74wf02	271	57	Suppression	suppression	NN
cord-318495-1w74wf02	271	58	of	of	IN
cord-318495-1w74wf02	271	59	viral	viral	JJ
cord-318495-1w74wf02	271	60	infectivity	infectivity	NN
cord-318495-1w74wf02	271	61	through	through	IN
cord-318495-1w74wf02	271	62	lethal	lethal	JJ
cord-318495-1w74wf02	271	63	defection	defection	NN
cord-318495-1w74wf02	271	64	Biased	bias	VBN
cord-318495-1w74wf02	271	65	hypermutation	hypermutation	NN
cord-318495-1w74wf02	271	66	and	and	CC
cord-318495-1w74wf02	271	67	other	other	JJ
cord-318495-1w74wf02	271	68	genetic	genetic	JJ
cord-318495-1w74wf02	271	69	changes	change	NNS
cord-318495-1w74wf02	271	70	in	in	IN
cord-318495-1w74wf02	271	71	defective	defective	JJ
cord-318495-1w74wf02	271	72	measles	measle	NNS
cord-318495-1w74wf02	271	73	viruses	virus	NNS
cord-318495-1w74wf02	271	74	in	in	IN
cord-318495-1w74wf02	271	75	human	human	JJ
cord-318495-1w74wf02	271	76	brain	brain	NN
cord-318495-1w74wf02	271	77	infections	infection	NNS
cord-318495-1w74wf02	271	78	Single	single	JJ
cord-318495-1w74wf02	271	79	-	-	HYPH
cord-318495-1w74wf02	271	80	strand	strand	NN
cord-318495-1w74wf02	271	81	specificity	specificity	NN
cord-318495-1w74wf02	271	82	of	of	IN
cord-318495-1w74wf02	271	83	APOBEC3	APOBEC3	NNP
cord-318495-1w74wf02	271	84	G	g	NN
cord-318495-1w74wf02	271	85	accounts	account	NNS
cord-318495-1w74wf02	271	86	for	for	IN
cord-318495-1w74wf02	271	87	minus	minus	JJ
cord-318495-1w74wf02	271	88	-	-	HYPH
cord-318495-1w74wf02	271	89	strand	strand	NN
cord-318495-1w74wf02	271	90	deamination	deamination	NN
cord-318495-1w74wf02	271	91	of	of	IN
cord-318495-1w74wf02	271	92	the	the	DT
cord-318495-1w74wf02	271	93	HIV	HIV	NNP
cord-318495-1w74wf02	271	94	genome	genome	NN
cord-318495-1w74wf02	271	95	Defective	Defective	NNP
cord-318495-1w74wf02	271	96	HIV-1	HIV-1	NNP
cord-318495-1w74wf02	271	97	proviruses	provirus	NNS
cord-318495-1w74wf02	271	98	produce	produce	VBP
cord-318495-1w74wf02	271	99	novel	novel	NN
cord-318495-1w74wf02	271	100	proteincoding	proteincode	VBG
cord-318495-1w74wf02	271	101	RNA	RNA	NNP
cord-318495-1w74wf02	271	102	species	specie	NNS
cord-318495-1w74wf02	271	103	in	in	IN
cord-318495-1w74wf02	271	104	HIV	HIV	NNP
cord-318495-1w74wf02	271	105	-	-	HYPH
cord-318495-1w74wf02	271	106	infected	infect	VBN
cord-318495-1w74wf02	271	107	patients	patient	NNS
cord-318495-1w74wf02	271	108	on	on	IN
cord-318495-1w74wf02	271	109	combination	combination	NN
cord-318495-1w74wf02	271	110	antiretroviral	antiretroviral	JJ
cord-318495-1w74wf02	271	111	therapy	therapy	NN
cord-318495-1w74wf02	271	112	Replication	replication	NN
cord-318495-1w74wf02	271	113	-	-	HYPH
cord-318495-1w74wf02	271	114	competent	competent	JJ
cord-318495-1w74wf02	271	115	noninduced	noninduced	JJ
cord-318495-1w74wf02	271	116	proviruses	provirus	NNS
cord-318495-1w74wf02	271	117	in	in	IN
cord-318495-1w74wf02	271	118	the	the	DT
cord-318495-1w74wf02	271	119	latent	latent	JJ
cord-318495-1w74wf02	271	120	reservoir	reservoir	NN
cord-318495-1w74wf02	271	121	increase	increase	NN
cord-318495-1w74wf02	271	122	barrier	barrier	NN
cord-318495-1w74wf02	271	123	to	to	IN
cord-318495-1w74wf02	271	124	HIV-1	HIV-1	NNP
cord-318495-1w74wf02	271	125	cure	cure	VB
cord-318495-1w74wf02	271	126	Defective	defective	JJ
cord-318495-1w74wf02	271	127	interfering	interfere	VBG
cord-318495-1w74wf02	271	128	particles	particle	NNS
cord-318495-1w74wf02	271	129	of	of	IN
cord-318495-1w74wf02	271	130	poliovirus	poliovirus	NN
cord-318495-1w74wf02	271	131	:	:	:
cord-318495-1w74wf02	271	132	mapping	mapping	NN
cord-318495-1w74wf02	271	133	of	of	IN
cord-318495-1w74wf02	271	134	the	the	DT
cord-318495-1w74wf02	271	135	deletion	deletion	NN
cord-318495-1w74wf02	271	136	and	and	CC
cord-318495-1w74wf02	271	137	evidence	evidence	NN
cord-318495-1w74wf02	271	138	that	that	IN
cord-318495-1w74wf02	271	139	the	the	DT
cord-318495-1w74wf02	271	140	deletions	deletion	NNS
cord-318495-1w74wf02	271	141	in	in	IN
cord-318495-1w74wf02	271	142	the	the	DT
cord-318495-1w74wf02	271	143	genomes	genome	NNS
cord-318495-1w74wf02	271	144	of	of	IN
cord-318495-1w74wf02	271	145	DI	DI	NNP
cord-318495-1w74wf02	271	146	Internal	Internal	NNP
cord-318495-1w74wf02	271	147	genome	genome	NN
cord-318495-1w74wf02	271	148	deletions	deletion	NNS
cord-318495-1w74wf02	271	149	in	in	IN
cord-318495-1w74wf02	271	150	two	two	CD
cord-318495-1w74wf02	271	151	distinct	distinct	JJ
cord-318495-1w74wf02	271	152	classes	class	NNS
cord-318495-1w74wf02	271	153	of	of	IN
cord-318495-1w74wf02	271	154	defective	defective	JJ
cord-318495-1w74wf02	271	155	interfering	interfere	VBG
cord-318495-1w74wf02	271	156	particles	particle	NNS
cord-318495-1w74wf02	271	157	of	of	IN
cord-318495-1w74wf02	271	158	vesicular	vesicular	JJ
cord-318495-1w74wf02	271	159	stomatitis	stomatitis	NN
cord-318495-1w74wf02	271	160	virus	virus	NN
cord-318495-1w74wf02	271	161	Influenza	Influenza	NNP
cord-318495-1w74wf02	271	162	defective	defective	JJ
cord-318495-1w74wf02	271	163	interfering	interfere	VBG
cord-318495-1w74wf02	271	164	viral	viral	JJ
cord-318495-1w74wf02	271	165	RNA	RNA	NNP
cord-318495-1w74wf02	271	166	is	be	VBZ
cord-318495-1w74wf02	271	167	formed	form	VBN
cord-318495-1w74wf02	271	168	by	by	IN
cord-318495-1w74wf02	271	169	internal	internal	JJ
cord-318495-1w74wf02	271	170	deletion	deletion	NN
cord-318495-1w74wf02	271	171	of	of	IN
cord-318495-1w74wf02	271	172	genomic	genomic	JJ
cord-318495-1w74wf02	271	173	RNA	RNA	NNP
cord-318495-1w74wf02	271	174	Vesicular	Vesicular	NNP
cord-318495-1w74wf02	271	175	stomatitis	stomatitis	NN
cord-318495-1w74wf02	271	176	virus	virus	NN
cord-318495-1w74wf02	271	177	defective	defective	JJ
cord-318495-1w74wf02	271	178	interfering	interfere	VBG
cord-318495-1w74wf02	271	179	particles	particle	NNS
cord-318495-1w74wf02	271	180	can	can	MD
cord-318495-1w74wf02	271	181	contain	contain	VB
cord-318495-1w74wf02	271	182	extensive	extensive	JJ
cord-318495-1w74wf02	271	183	genomic	genomic	JJ
cord-318495-1w74wf02	271	184	sequence	sequence	NN
cord-318495-1w74wf02	271	185	rearrangements	rearrangement	NNS
cord-318495-1w74wf02	271	186	and	and	CC
cord-318495-1w74wf02	271	187	base	base	NN
cord-318495-1w74wf02	271	188	substitutions	substitution	NNS
cord-318495-1w74wf02	271	189	A	a	DT
cord-318495-1w74wf02	271	190	defective	defective	JJ
cord-318495-1w74wf02	271	191	interfering	interfere	VBG
cord-318495-1w74wf02	271	192	RNA	RNA	NNP
cord-318495-1w74wf02	271	193	that	that	WDT
cord-318495-1w74wf02	271	194	contains	contain	VBZ
cord-318495-1w74wf02	271	195	a	a	DT
cord-318495-1w74wf02	271	196	mosaic	mosaic	NN
cord-318495-1w74wf02	271	197	of	of	IN
cord-318495-1w74wf02	271	198	a	a	DT
cord-318495-1w74wf02	271	199	plant	plant	NN
cord-318495-1w74wf02	271	200	virus	virus	NN
cord-318495-1w74wf02	271	201	genome	genome	NN
cord-318495-1w74wf02	271	202	Isolation	isolation	NN
cord-318495-1w74wf02	271	203	and	and	CC
cord-318495-1w74wf02	271	204	characterization	characterization	NN
cord-318495-1w74wf02	271	205	of	of	IN
cord-318495-1w74wf02	271	206	an	an	DT
cord-318495-1w74wf02	271	207	arterivirus	arterivirus	NN
cord-318495-1w74wf02	271	208	defective	defective	JJ
cord-318495-1w74wf02	271	209	interfering	interfere	VBG
cord-318495-1w74wf02	271	210	RNA	RNA	NNP
cord-318495-1w74wf02	271	211	genome	genome	NN
cord-318495-1w74wf02	271	212	Isolation	isolation	NN
cord-318495-1w74wf02	271	213	and	and	CC
cord-318495-1w74wf02	271	214	characterization	characterization	NN
cord-318495-1w74wf02	271	215	of	of	IN
cord-318495-1w74wf02	271	216	Sendai	Sendai	NNP
cord-318495-1w74wf02	271	217	virus	virus	NN
cord-318495-1w74wf02	271	218	DI	DI	NNP
cord-318495-1w74wf02	271	219	-	-	HYPH
cord-318495-1w74wf02	271	220	RNAs	RNAs	NNPS
cord-318495-1w74wf02	272	1	The	the	DT
cord-318495-1w74wf02	272	2	origins	origin	NNS
cord-318495-1w74wf02	272	3	of	of	IN
cord-318495-1w74wf02	272	4	defective	defective	JJ
cord-318495-1w74wf02	272	5	interfering	interfere	VBG
cord-318495-1w74wf02	272	6	particles	particle	NNS
cord-318495-1w74wf02	272	7	of	of	IN
cord-318495-1w74wf02	272	8	the	the	DT
cord-318495-1w74wf02	272	9	negative	negative	JJ
cord-318495-1w74wf02	272	10	-	-	HYPH
cord-318495-1w74wf02	272	11	strand	strand	NN
cord-318495-1w74wf02	272	12	RNA	RNA	NNP
cord-318495-1w74wf02	272	13	viruses	virus	NNS
cord-318495-1w74wf02	272	14	Structure	structure	NN
cord-318495-1w74wf02	272	15	and	and	CC
cord-318495-1w74wf02	272	16	origin	origin	NN
cord-318495-1w74wf02	272	17	of	of	IN
cord-318495-1w74wf02	272	18	a	a	DT
cord-318495-1w74wf02	272	19	novel	novel	JJ
cord-318495-1w74wf02	272	20	class	class	NN
cord-318495-1w74wf02	272	21	of	of	IN
cord-318495-1w74wf02	272	22	defective	defective	JJ
cord-318495-1w74wf02	272	23	interfering	interfere	VBG
cord-318495-1w74wf02	272	24	particle	particle	NN
cord-318495-1w74wf02	272	25	of	of	IN
cord-318495-1w74wf02	272	26	vesicular	vesicular	JJ
cord-318495-1w74wf02	272	27	stomatitis	stomatitis	NN
cord-318495-1w74wf02	272	28	virus	virus	NN
cord-318495-1w74wf02	273	1	Inverted	inverted	JJ
cord-318495-1w74wf02	273	2	complementary	complementary	JJ
cord-318495-1w74wf02	273	3	terminal	terminal	NN
cord-318495-1w74wf02	273	4	sequences	sequence	NNS
cord-318495-1w74wf02	273	5	in	in	IN
cord-318495-1w74wf02	273	6	single	single	RB
cord-318495-1w74wf02	273	7	-	-	HYPH
cord-318495-1w74wf02	273	8	stranded	stranded	JJ
cord-318495-1w74wf02	273	9	RNAs	rna	NNS
cord-318495-1w74wf02	273	10	and	and	CC
cord-318495-1w74wf02	273	11	snap	snap	VB
cord-318495-1w74wf02	273	12	-	-	HYPH
cord-318495-1w74wf02	273	13	back	back	NN
cord-318495-1w74wf02	273	14	RNAs	rna	NNS
cord-318495-1w74wf02	273	15	from	from	IN
cord-318495-1w74wf02	273	16	vesicular	vesicular	JJ
cord-318495-1w74wf02	273	17	stomatitis	stomatitis	NN
cord-318495-1w74wf02	273	18	defective	defective	JJ
cord-318495-1w74wf02	273	19	interfering	interfere	VBG
cord-318495-1w74wf02	273	20	particles	particle	NNS
cord-318495-1w74wf02	273	21	Genomic	genomic	JJ
cord-318495-1w74wf02	273	22	and	and	CC
cord-318495-1w74wf02	273	23	copy	copy	NN
cord-318495-1w74wf02	273	24	-	-	HYPH
cord-318495-1w74wf02	273	25	back	back	NN
cord-318495-1w74wf02	274	1	3′	3′	CD
cord-318495-1w74wf02	274	2	termini	terminus	NNS
cord-318495-1w74wf02	274	3	in	in	IN
cord-318495-1w74wf02	274	4	Sendai	Sendai	NNP
cord-318495-1w74wf02	274	5	virus	virus	NN
cord-318495-1w74wf02	274	6	defective	defective	JJ
cord-318495-1w74wf02	274	7	interfering	interfere	VBG
cord-318495-1w74wf02	274	8	RNA	RNA	NNP
cord-318495-1w74wf02	274	9	species	specie	NNS
cord-318495-1w74wf02	274	10	Origin	origin	NN
cord-318495-1w74wf02	274	11	and	and	CC
cord-318495-1w74wf02	274	12	replication	replication	NN
cord-318495-1w74wf02	274	13	of	of	IN
cord-318495-1w74wf02	274	14	defective	defective	JJ
cord-318495-1w74wf02	274	15	interfering	interfere	VBG
cord-318495-1w74wf02	274	16	particles	particle	NNS
cord-318495-1w74wf02	275	1	Defective	defective	JJ
cord-318495-1w74wf02	275	2	interfering	interfere	VBG
cord-318495-1w74wf02	275	3	Semliki	Semliki	NNP
cord-318495-1w74wf02	275	4	Forest	Forest	NNP
cord-318495-1w74wf02	275	5	virus	virus	NN
cord-318495-1w74wf02	275	6	populations	population	NNS
cord-318495-1w74wf02	275	7	are	be	VBP
cord-318495-1w74wf02	275	8	biologically	biologically	RB
cord-318495-1w74wf02	275	9	and	and	CC
cord-318495-1w74wf02	275	10	physically	physically	RB
cord-318495-1w74wf02	275	11	heterogeneous	heterogeneous	JJ
cord-318495-1w74wf02	275	12	Parallel	Parallel	NNP
cord-318495-1w74wf02	275	13	ClickSeq	ClickSeq	NNP
cord-318495-1w74wf02	275	14	and	and	CC
cord-318495-1w74wf02	275	15	Nanopore	Nanopore	NNP
cord-318495-1w74wf02	275	16	sequencing	sequencing	NN
cord-318495-1w74wf02	275	17	elucidates	elucidate	VBZ
cord-318495-1w74wf02	275	18	the	the	DT
cord-318495-1w74wf02	275	19	rapid	rapid	JJ
cord-318495-1w74wf02	275	20	evolution	evolution	NN
cord-318495-1w74wf02	275	21	of	of	IN
cord-318495-1w74wf02	275	22	defective	defective	JJ
cord-318495-1w74wf02	275	23	-	-	HYPH
cord-318495-1w74wf02	275	24	interfering	interfere	VBG
cord-318495-1w74wf02	275	25	RNAs	rna	NNS
cord-318495-1w74wf02	275	26	in	in	IN
cord-318495-1w74wf02	275	27	Flock	Flock	NNP
cord-318495-1w74wf02	275	28	House	House	NNP
cord-318495-1w74wf02	275	29	virus	virus	NN
cord-318495-1w74wf02	275	30	DI	di	NN
cord-318495-1w74wf02	275	31	-	-	HYPH
cord-318495-1w74wf02	275	32	tector	tector	NN
cord-318495-1w74wf02	275	33	:	:	:
cord-318495-1w74wf02	275	34	defective	defective	JJ
cord-318495-1w74wf02	275	35	interfering	interfere	VBG
cord-318495-1w74wf02	275	36	viral	viral	JJ
cord-318495-1w74wf02	275	37	genomes	genome	NNS
cord-318495-1w74wf02	275	38	detector	detector	NN
cord-318495-1w74wf02	275	39	for	for	IN
cord-318495-1w74wf02	275	40	next	next	JJ
cord-318495-1w74wf02	275	41	generation	generation	NN
cord-318495-1w74wf02	275	42	sequencing	sequencing	NN
cord-318495-1w74wf02	275	43	data	datum	NNS
cord-318495-1w74wf02	275	44	A	a	DT
cord-318495-1w74wf02	275	45	specific	specific	JJ
cord-318495-1w74wf02	275	46	sequence	sequence	NN
cord-318495-1w74wf02	275	47	in	in	IN
cord-318495-1w74wf02	275	48	the	the	DT
cord-318495-1w74wf02	275	49	genome	genome	NN
cord-318495-1w74wf02	275	50	of	of	IN
cord-318495-1w74wf02	275	51	respiratory	respiratory	JJ
cord-318495-1w74wf02	275	52	syncytial	syncytial	JJ
cord-318495-1w74wf02	275	53	virus	virus	NN
cord-318495-1w74wf02	275	54	regulates	regulate	VBZ
cord-318495-1w74wf02	275	55	the	the	DT
cord-318495-1w74wf02	275	56	generation	generation	NN
cord-318495-1w74wf02	275	57	of	of	IN
cord-318495-1w74wf02	275	58	copy	copy	NN
cord-318495-1w74wf02	275	59	-	-	HYPH
cord-318495-1w74wf02	275	60	back	back	NN
cord-318495-1w74wf02	275	61	defective	defective	JJ
cord-318495-1w74wf02	275	62	viral	viral	JJ
cord-318495-1w74wf02	275	63	genomes	genome	NNS
cord-318495-1w74wf02	275	64	Sequence	sequence	NN
cord-318495-1w74wf02	275	65	analysis	analysis	NN
cord-318495-1w74wf02	275	66	of	of	IN
cord-318495-1w74wf02	275	67	in	in	IN
cord-318495-1w74wf02	275	68	vivo	vivo	NN
cord-318495-1w74wf02	275	69	defective	defective	JJ
cord-318495-1w74wf02	275	70	interfering	interfere	VBG
cord-318495-1w74wf02	275	71	-	-	HYPH
cord-318495-1w74wf02	275	72	like	like	JJ
cord-318495-1w74wf02	275	73	RNA	RNA	NNP
cord-318495-1w74wf02	275	74	of	of	IN
cord-318495-1w74wf02	275	75	influenza	influenza	NN
cord-318495-1w74wf02	275	76	A	a	DT
cord-318495-1w74wf02	275	77	H1N1	H1N1	NNP
cord-318495-1w74wf02	275	78	pandemic	pandemic	NN
cord-318495-1w74wf02	275	79	virus	virus	NN
cord-318495-1w74wf02	275	80	Excessive	excessive	JJ
cord-318495-1w74wf02	275	81	production	production	NN
cord-318495-1w74wf02	275	82	and	and	CC
cord-318495-1w74wf02	275	83	extreme	extreme	JJ
cord-318495-1w74wf02	275	84	editing	editing	NN
cord-318495-1w74wf02	275	85	of	of	IN
cord-318495-1w74wf02	275	86	human	human	JJ
cord-318495-1w74wf02	275	87	metapneumovirus	metapneumovirus	NN
cord-318495-1w74wf02	275	88	defective	defective	JJ
cord-318495-1w74wf02	275	89	interfering	interfere	VBG
cord-318495-1w74wf02	275	90	RNA	RNA	NNP
cord-318495-1w74wf02	275	91	is	be	VBZ
cord-318495-1w74wf02	275	92	associated	associate	VBN
cord-318495-1w74wf02	275	93	with	with	IN
cord-318495-1w74wf02	275	94	type	type	NN
cord-318495-1w74wf02	276	1	I	-PRON-	PRP
cord-318495-1w74wf02	276	2	IFN	IFN	NNP
cord-318495-1w74wf02	276	3	induction	induction	NN
cord-318495-1w74wf02	276	4	Measles	Measles	NNP
cord-318495-1w74wf02	276	5	virus	virus	NN
cord-318495-1w74wf02	276	6	defective	defective	JJ
cord-318495-1w74wf02	276	7	interfering	interfere	VBG
cord-318495-1w74wf02	276	8	RNAs	rna	NNS
cord-318495-1w74wf02	276	9	are	be	VBP
cord-318495-1w74wf02	276	10	generated	generate	VBN
cord-318495-1w74wf02	276	11	frequently	frequently	RB
cord-318495-1w74wf02	276	12	and	and	CC
cord-318495-1w74wf02	276	13	early	early	RB
cord-318495-1w74wf02	276	14	in	in	IN
cord-318495-1w74wf02	276	15	the	the	DT
cord-318495-1w74wf02	276	16	absence	absence	NN
cord-318495-1w74wf02	276	17	of	of	IN
cord-318495-1w74wf02	276	18	C	C	NNP
cord-318495-1w74wf02	276	19	protein	protein	NN
cord-318495-1w74wf02	276	20	and	and	CC
cord-318495-1w74wf02	276	21	pan	pan	NN
cord-318495-1w74wf02	276	22	be	be	VB
cord-318495-1w74wf02	276	23	destabilized	destabilize	VBN
cord-318495-1w74wf02	276	24	by	by	IN
cord-318495-1w74wf02	276	25	adenosine	adenosine	NN
cord-318495-1w74wf02	276	26	deaminase	deaminase	NN
cord-318495-1w74wf02	276	27	acting	act	VBG
cord-318495-1w74wf02	276	28	on	on	IN
cord-318495-1w74wf02	276	29	RNA-1-like	rna-1-like	IN
cord-318495-1w74wf02	276	30	hypermutations	hypermutation	NNS
cord-318495-1w74wf02	276	31	Defective	defective	JJ
cord-318495-1w74wf02	276	32	viral	viral	JJ
cord-318495-1w74wf02	276	33	genomes	genome	NNS
cord-318495-1w74wf02	276	34	arising	arise	VBG
cord-318495-1w74wf02	276	35	in	in	IN
cord-318495-1w74wf02	276	36	vivo	vivo	NN
cord-318495-1w74wf02	276	37	provide	provide	VBP
cord-318495-1w74wf02	276	38	critical	critical	JJ
cord-318495-1w74wf02	276	39	danger	danger	NN
cord-318495-1w74wf02	276	40	signals	signal	NNS
cord-318495-1w74wf02	276	41	for	for	IN
cord-318495-1w74wf02	276	42	the	the	DT
cord-318495-1w74wf02	276	43	triggering	triggering	NN
cord-318495-1w74wf02	276	44	of	of	IN
cord-318495-1w74wf02	276	45	lung	lung	NN
cord-318495-1w74wf02	276	46	antiviral	antiviral	JJ
cord-318495-1w74wf02	276	47	immunity	immunity	NN
cord-318495-1w74wf02	277	1	Immunostimulatory	immunostimulatory	JJ
cord-318495-1w74wf02	277	2	defective	defective	JJ
cord-318495-1w74wf02	277	3	viral	viral	JJ
cord-318495-1w74wf02	277	4	genomes	genome	NNS
cord-318495-1w74wf02	277	5	from	from	IN
cord-318495-1w74wf02	277	6	respiratory	respiratory	JJ
cord-318495-1w74wf02	277	7	syncytial	syncytial	JJ
cord-318495-1w74wf02	277	8	virus	virus	NN
cord-318495-1w74wf02	277	9	promote	promote	VBP
cord-318495-1w74wf02	277	10	a	a	DT
cord-318495-1w74wf02	277	11	strong	strong	JJ
cord-318495-1w74wf02	277	12	innate	innate	JJ
cord-318495-1w74wf02	277	13	antiviral	antiviral	JJ
cord-318495-1w74wf02	277	14	response	response	NN
cord-318495-1w74wf02	277	15	during	during	IN
cord-318495-1w74wf02	277	16	Infection	Infection	NNP
cord-318495-1w74wf02	277	17	in	in	IN
cord-318495-1w74wf02	277	18	mice	mouse	NNS
cord-318495-1w74wf02	277	19	and	and	CC
cord-318495-1w74wf02	277	20	humans	human	NNS
cord-318495-1w74wf02	277	21	Loss	Loss	NNP
cord-318495-1w74wf02	277	22	of	of	IN
cord-318495-1w74wf02	277	23	Sendai	Sendai	NNP
cord-318495-1w74wf02	277	24	virus	virus	NN
cord-318495-1w74wf02	277	25	C	c	NN
cord-318495-1w74wf02	277	26	protein	protein	NN
cord-318495-1w74wf02	277	27	leads	lead	VBZ
cord-318495-1w74wf02	277	28	to	to	IN
cord-318495-1w74wf02	277	29	accumulation	accumulation	NN
cord-318495-1w74wf02	277	30	of	of	IN
cord-318495-1w74wf02	277	31	RIG-	RIG-	NNP
cord-318495-1w74wf02	278	1	I	-PRON-	PRP
cord-318495-1w74wf02	278	2	immunostimulatory	immunostimulatory	NNP
cord-318495-1w74wf02	278	3	defective	defective	JJ
cord-318495-1w74wf02	278	4	interfering	interfere	VBG
cord-318495-1w74wf02	278	5	RNA	RNA	NNP
cord-318495-1w74wf02	278	6	Deep	deep	JJ
cord-318495-1w74wf02	278	7	sequencing	sequencing	NN
cord-318495-1w74wf02	278	8	analysis	analysis	NN
cord-318495-1w74wf02	278	9	of	of	IN
cord-318495-1w74wf02	278	10	defective	defective	JJ
cord-318495-1w74wf02	278	11	genomes	genome	NNS
cord-318495-1w74wf02	278	12	of	of	IN
cord-318495-1w74wf02	278	13	parainfluenza	parainfluenza	NNP
cord-318495-1w74wf02	278	14	virus	virus	NNP
cord-318495-1w74wf02	278	15	5	5	CD
cord-318495-1w74wf02	278	16	and	and	CC
cord-318495-1w74wf02	278	17	their	-PRON-	PRP$
cord-318495-1w74wf02	278	18	role	role	NN
cord-318495-1w74wf02	278	19	in	in	IN
cord-318495-1w74wf02	278	20	interferon	interferon	NN
cord-318495-1w74wf02	278	21	induction	induction	NN
cord-318495-1w74wf02	278	22	Quantitative	quantitative	JJ
cord-318495-1w74wf02	278	23	characterization	characterization	NN
cord-318495-1w74wf02	278	24	of	of	IN
cord-318495-1w74wf02	278	25	defective	defective	JJ
cord-318495-1w74wf02	278	26	virus	virus	NN
cord-318495-1w74wf02	278	27	emergence	emergence	NN
cord-318495-1w74wf02	278	28	by	by	IN
cord-318495-1w74wf02	278	29	deep	deep	JJ
cord-318495-1w74wf02	278	30	sequencing	sequencing	NN
cord-318495-1w74wf02	279	1	Does	do	VBZ
cord-318495-1w74wf02	279	2	the	the	DT
cord-318495-1w74wf02	279	3	higher	high	JJR
cord-318495-1w74wf02	279	4	order	order	NN
cord-318495-1w74wf02	279	5	structure	structure	NN
cord-318495-1w74wf02	279	6	of	of	IN
cord-318495-1w74wf02	279	7	the	the	DT
cord-318495-1w74wf02	279	8	influenza	influenza	NN
cord-318495-1w74wf02	279	9	virus	virus	NN
cord-318495-1w74wf02	279	10	ribonucleoprotein	ribonucleoprotein	NN
cord-318495-1w74wf02	279	11	guide	guide	NN
cord-318495-1w74wf02	279	12	sequence	sequence	NN
cord-318495-1w74wf02	279	13	rearrangements	rearrangement	NNS
cord-318495-1w74wf02	279	14	in	in	IN
cord-318495-1w74wf02	279	15	influenza	influenza	JJ
cord-318495-1w74wf02	279	16	viral	viral	JJ
cord-318495-1w74wf02	279	17	RNA	RNA	NNP
cord-318495-1w74wf02	279	18	?	?	.
cord-318495-1w74wf02	280	1	Sequence	sequence	NN
cord-318495-1w74wf02	280	2	-	-	HYPH
cord-318495-1w74wf02	280	3	specific	specific	JJ
cord-318495-1w74wf02	280	4	fidelity	fidelity	NN
cord-318495-1w74wf02	280	5	alterations	alteration	NNS
cord-318495-1w74wf02	280	6	associated	associate	VBN
cord-318495-1w74wf02	280	7	with	with	IN
cord-318495-1w74wf02	280	8	West	West	NNP
cord-318495-1w74wf02	280	9	Nile	Nile	NNP
cord-318495-1w74wf02	280	10	virus	virus	NN
cord-318495-1w74wf02	280	11	attenuation	attenuation	NN
cord-318495-1w74wf02	280	12	in	in	IN
cord-318495-1w74wf02	280	13	mosquitoes	mosquito	NNS
cord-318495-1w74wf02	281	1	Alphavirus	Alphavirus	NNP
cord-318495-1w74wf02	281	2	mutator	mutator	NN
cord-318495-1w74wf02	281	3	variants	variant	NNS
cord-318495-1w74wf02	281	4	present	present	VBP
cord-318495-1w74wf02	281	5	host	host	NN
cord-318495-1w74wf02	281	6	-	-	HYPH
cord-318495-1w74wf02	281	7	specific	specific	JJ
cord-318495-1w74wf02	281	8	defects	defect	NNS
cord-318495-1w74wf02	281	9	and	and	CC
cord-318495-1w74wf02	281	10	attenuation	attenuation	NN
cord-318495-1w74wf02	281	11	in	in	IN
cord-318495-1w74wf02	281	12	mammalian	mammalian	JJ
cord-318495-1w74wf02	281	13	and	and	CC
cord-318495-1w74wf02	281	14	insect	insect	NN
cord-318495-1w74wf02	281	15	models	model	NNS
cord-318495-1w74wf02	282	1	Reduced	reduce	VBN
cord-318495-1w74wf02	282	2	accumulation	accumulation	NN
cord-318495-1w74wf02	282	3	of	of	IN
cord-318495-1w74wf02	282	4	defective	defective	JJ
cord-318495-1w74wf02	282	5	viral	viral	JJ
cord-318495-1w74wf02	282	6	genomes	genome	NNS
cord-318495-1w74wf02	282	7	contributes	contribute	VBZ
cord-318495-1w74wf02	282	8	to	to	IN
cord-318495-1w74wf02	282	9	severe	severe	JJ
cord-318495-1w74wf02	282	10	outcome	outcome	NN
cord-318495-1w74wf02	282	11	in	in	IN
cord-318495-1w74wf02	282	12	influenza	influenza	NN
cord-318495-1w74wf02	282	13	virus	virus	NN
cord-318495-1w74wf02	282	14	infected	infect	VBN
cord-318495-1w74wf02	282	15	patients	patient	NNS
cord-318495-1w74wf02	282	16	Low	Low	NNP
cord-318495-1w74wf02	282	17	-	-	HYPH
cord-318495-1w74wf02	282	18	Fidelity	Fidelity	NNP
cord-318495-1w74wf02	282	19	Polymerases	Polymerases	NNPS
cord-318495-1w74wf02	282	20	of	of	IN
cord-318495-1w74wf02	282	21	Alphaviruses	Alphaviruses	NNP
cord-318495-1w74wf02	282	22	Recombine	recombine	VB
cord-318495-1w74wf02	282	23	at	at	IN
cord-318495-1w74wf02	282	24	Higher	high	JJR
cord-318495-1w74wf02	282	25	Rates	rate	NNS
cord-318495-1w74wf02	282	26	To	to	TO
cord-318495-1w74wf02	282	27	Overproduce	overproduce	VB
cord-318495-1w74wf02	282	28	Defective	defective	JJ
cord-318495-1w74wf02	282	29	Interfering	interfere	VBG
cord-318495-1w74wf02	282	30	Particles	particle	NNS
cord-318495-1w74wf02	283	1	A	a	DT
cord-318495-1w74wf02	283	2	single	single	JJ
cord-318495-1w74wf02	283	3	amino	amino	NN
cord-318495-1w74wf02	283	4	acid	acid	NN
cord-318495-1w74wf02	283	5	mutation	mutation	NN
cord-318495-1w74wf02	283	6	in	in	IN
cord-318495-1w74wf02	283	7	the	the	DT
cord-318495-1w74wf02	283	8	PA	PA	NNP
cord-318495-1w74wf02	283	9	subunit	subunit	NN
cord-318495-1w74wf02	283	10	of	of	IN
cord-318495-1w74wf02	283	11	the	the	DT
cord-318495-1w74wf02	283	12	influenza	influenza	NN
cord-318495-1w74wf02	283	13	virus	virus	NN
cord-318495-1w74wf02	283	14	RNA	RNA	NNP
cord-318495-1w74wf02	283	15	polymerase	polymerase	NN
cord-318495-1w74wf02	283	16	promotes	promote	VBZ
cord-318495-1w74wf02	283	17	the	the	DT
cord-318495-1w74wf02	283	18	generation	generation	NN
cord-318495-1w74wf02	283	19	of	of	IN
cord-318495-1w74wf02	283	20	defective	defective	JJ
cord-318495-1w74wf02	283	21	interfering	interfere	VBG
cord-318495-1w74wf02	283	22	RNAs	rna	NNS
cord-318495-1w74wf02	283	23	Mutations	Mutations	NNPS
cord-318495-1w74wf02	283	24	in	in	IN
cord-318495-1w74wf02	283	25	the	the	DT
cord-318495-1w74wf02	283	26	RNA	RNA	NNP
cord-318495-1w74wf02	283	27	-	-	HYPH
cord-318495-1w74wf02	283	28	binding	bind	VBG
cord-318495-1w74wf02	283	29	domains	domain	NNS
cord-318495-1w74wf02	283	30	of	of	IN
cord-318495-1w74wf02	283	31	tombusvirus	tombusvirus	NNP
cord-318495-1w74wf02	283	32	replicase	replicase	NNP
cord-318495-1w74wf02	283	33	proteins	protein	NNS
cord-318495-1w74wf02	283	34	affect	affect	VBP
cord-318495-1w74wf02	283	35	RNA	RNA	NNP
cord-318495-1w74wf02	283	36	recombination	recombination	NN
cord-318495-1w74wf02	283	37	in	in	IN
cord-318495-1w74wf02	283	38	vivo	vivo	NNP
cord-318495-1w74wf02	283	39	Mutation	Mutation	NNP
cord-318495-1w74wf02	283	40	in	in	IN
cord-318495-1w74wf02	283	41	NS2	NS2	NNP
cord-318495-1w74wf02	283	42	,	,	,
cord-318495-1w74wf02	283	43	a	a	DT
cord-318495-1w74wf02	283	44	nonstructural	nonstructural	JJ
cord-318495-1w74wf02	283	45	protein	protein	NN
cord-318495-1w74wf02	283	46	of	of	IN
cord-318495-1w74wf02	283	47	influenza	influenza	NN
cord-318495-1w74wf02	283	48	A	a	DT
cord-318495-1w74wf02	283	49	virus	virus	NN
cord-318495-1w74wf02	283	50	,	,	,
cord-318495-1w74wf02	283	51	extragenically	extragenically	RB
cord-318495-1w74wf02	283	52	causes	cause	VBZ
cord-318495-1w74wf02	283	53	aberrant	aberrant	JJ
cord-318495-1w74wf02	283	54	replication	replication	NN
cord-318495-1w74wf02	283	55	and	and	CC
cord-318495-1w74wf02	283	56	expression	expression	NN
cord-318495-1w74wf02	283	57	of	of	IN
cord-318495-1w74wf02	283	58	the	the	DT
cord-318495-1w74wf02	283	59	PA	PA	NNP
cord-318495-1w74wf02	283	60	gene	gene	NN
cord-318495-1w74wf02	283	61	and	and	CC
cord-318495-1w74wf02	283	62	leads	lead	VBZ
cord-318495-1w74wf02	283	63	to	to	IN
cord-318495-1w74wf02	283	64	generation	generation	NN
cord-318495-1w74wf02	283	65	of	of	IN
cord-318495-1w74wf02	283	66	defective	defective	JJ
cord-318495-1w74wf02	283	67	interfering	interfere	VBG
cord-318495-1w74wf02	283	68	particles	particle	NNS
cord-318495-1w74wf02	284	1	A	a	DT
cord-318495-1w74wf02	284	2	single	single	JJ
cord-318495-1w74wf02	284	3	amino	amino	NN
cord-318495-1w74wf02	284	4	acid	acid	NN
cord-318495-1w74wf02	284	5	substitution	substitution	NN
cord-318495-1w74wf02	284	6	within	within	IN
cord-318495-1w74wf02	284	7	the	the	DT
cord-318495-1w74wf02	284	8	paramyxovirus	paramyxovirus	JJ
cord-318495-1w74wf02	284	9	Sendai	Sendai	NNP
cord-318495-1w74wf02	284	10	virus	virus	NN
cord-318495-1w74wf02	284	11	nucleoprotein	nucleoprotein	NN
cord-318495-1w74wf02	284	12	is	be	VBZ
cord-318495-1w74wf02	284	13	a	a	DT
cord-318495-1w74wf02	284	14	critical	critical	JJ
cord-318495-1w74wf02	284	15	determinant	determinant	NN
cord-318495-1w74wf02	284	16	for	for	IN
cord-318495-1w74wf02	284	17	production	production	NN
cord-318495-1w74wf02	284	18	of	of	IN
cord-318495-1w74wf02	284	19	interferon	interferon	NN
cord-318495-1w74wf02	284	20	-	-	HYPH
cord-318495-1w74wf02	284	21	beta	beta	NN
cord-318495-1w74wf02	284	22	-	-	HYPH
cord-318495-1w74wf02	284	23	inducing	induce	VBG
cord-318495-1w74wf02	284	24	copyback	copyback	NN
cord-318495-1w74wf02	284	25	-	-	HYPH
cord-318495-1w74wf02	284	26	type	type	NN
cord-318495-1w74wf02	284	27	defective	defective	JJ
cord-318495-1w74wf02	284	28	interfering	interfere	VBG
cord-318495-1w74wf02	284	29	genomes	genome	NNS
cord-318495-1w74wf02	284	30	The	the	DT
cord-318495-1w74wf02	284	31	lymphocytic	lymphocytic	JJ
cord-318495-1w74wf02	284	32	choriomeningitis	choriomeningitis	NNP
cord-318495-1w74wf02	284	33	virus	virus	NN
cord-318495-1w74wf02	284	34	matrix	matrix	NN
cord-318495-1w74wf02	284	35	protein	protein	NN
cord-318495-1w74wf02	284	36	PPXY	PPXY	NNP
cord-318495-1w74wf02	284	37	late	late	JJ
cord-318495-1w74wf02	284	38	domain	domain	NN
cord-318495-1w74wf02	284	39	drives	drive	VBZ
cord-318495-1w74wf02	284	40	the	the	DT
cord-318495-1w74wf02	284	41	production	production	NN
cord-318495-1w74wf02	284	42	of	of	IN
cord-318495-1w74wf02	284	43	defective	defective	JJ
cord-318495-1w74wf02	284	44	interfering	interfere	VBG
cord-318495-1w74wf02	284	45	particles	particle	NNS
cord-318495-1w74wf02	284	46	recombination	recombination	NN
cord-318495-1w74wf02	284	47	in	in	IN
cord-318495-1w74wf02	284	48	tombusviruses	tombusviruse	NNS
cord-318495-1w74wf02	284	49	:	:	:
cord-318495-1w74wf02	285	1	generation	generation	NN
cord-318495-1w74wf02	285	2	and	and	CC
cord-318495-1w74wf02	285	3	evolution	evolution	NN
cord-318495-1w74wf02	285	4	of	of	IN
cord-318495-1w74wf02	285	5	defective	defective	JJ
cord-318495-1w74wf02	285	6	interfering	interfere	VBG
cord-318495-1w74wf02	285	7	RNAs	rna	NNS
cord-318495-1w74wf02	285	8	by	by	IN
cord-318495-1w74wf02	285	9	stepwise	stepwise	JJ
cord-318495-1w74wf02	285	10	deletions	deletion	NNS
cord-318495-1w74wf02	286	1	Factors	factor	NNS
cord-318495-1w74wf02	286	2	regulating	regulate	VBG
cord-318495-1w74wf02	286	3	template	template	NN
cord-318495-1w74wf02	286	4	switch	switch	NN
cord-318495-1w74wf02	286	5	in	in	IN
cord-318495-1w74wf02	286	6	vitro	vitro	FW
cord-318495-1w74wf02	286	7	by	by	IN
cord-318495-1w74wf02	286	8	viral	viral	JJ
cord-318495-1w74wf02	286	9	RNA	RNA	NNP
cord-318495-1w74wf02	286	10	-	-	HYPH
cord-318495-1w74wf02	286	11	dependent	dependent	JJ
cord-318495-1w74wf02	286	12	RNA	RNA	NNP
cord-318495-1w74wf02	286	13	polymerases	polymerase	NNS
cord-318495-1w74wf02	286	14	:	:	:
cord-318495-1w74wf02	286	15	implications	implication	NNS
cord-318495-1w74wf02	286	16	for	for	IN
cord-318495-1w74wf02	286	17	RNA	RNA	NNP
cord-318495-1w74wf02	286	18	-	-	HYPH
cord-318495-1w74wf02	286	19	RNA	RNA	NNP
cord-318495-1w74wf02	286	20	recombination	recombination	NN
cord-318495-1w74wf02	286	21	Efficient	efficient	JJ
cord-318495-1w74wf02	286	22	in	in	IN
cord-318495-1w74wf02	286	23	vitro	vitro	FW
cord-318495-1w74wf02	286	24	system	system	NN
cord-318495-1w74wf02	286	25	of	of	IN
cord-318495-1w74wf02	286	26	homologous	homologous	JJ
cord-318495-1w74wf02	286	27	recombination	recombination	NN
cord-318495-1w74wf02	286	28	in	in	IN
cord-318495-1w74wf02	286	29	brome	brome	NN
cord-318495-1w74wf02	286	30	mosaic	mosaic	NN
cord-318495-1w74wf02	286	31	bromovirus	bromovirus	NNP
cord-318495-1w74wf02	286	32	Silencing	Silencing	NNP
cord-318495-1w74wf02	286	33	of	of	IN
cord-318495-1w74wf02	286	34	Nicotiana	Nicotiana	NNP
cord-318495-1w74wf02	286	35	benthamiana	benthamiana	NNP
cord-318495-1w74wf02	287	1	Xrn4p	Xrn4p	NNP
cord-318495-1w74wf02	287	2	exoribonuclease	exoribonuclease	NNP
cord-318495-1w74wf02	287	3	promotes	promote	VBZ
cord-318495-1w74wf02	287	4	tombusvirus	tombusvirus	NNP
cord-318495-1w74wf02	287	5	RNA	RNA	NNP
cord-318495-1w74wf02	287	6	accumulation	accumulation	NN
cord-318495-1w74wf02	287	7	and	and	CC
cord-318495-1w74wf02	287	8	recombination	recombination	NN
cord-318495-1w74wf02	288	1	Targeting	target	VBG
cord-318495-1w74wf02	288	2	expression	expression	NN
cord-318495-1w74wf02	288	3	of	of	IN
cord-318495-1w74wf02	288	4	the	the	DT
cord-318495-1w74wf02	288	5	leukemogenic	leukemogenic	NNP
cord-318495-1w74wf02	288	6	PML	PML	NNP
cord-318495-1w74wf02	288	7	-	-	HYPH
cord-318495-1w74wf02	288	8	RARalpha	RARalpha	NNP
cord-318495-1w74wf02	288	9	fusion	fusion	NN
cord-318495-1w74wf02	288	10	protein	protein	NN
cord-318495-1w74wf02	288	11	by	by	IN
cord-318495-1w74wf02	288	12	lentiviral	lentiviral	JJ
cord-318495-1w74wf02	288	13	vector	vector	NN
cord-318495-1w74wf02	288	14	-	-	HYPH
cord-318495-1w74wf02	288	15	mediated	mediate	VBN
cord-318495-1w74wf02	288	16	small	small	JJ
cord-318495-1w74wf02	288	17	interfering	interfere	VBG
cord-318495-1w74wf02	288	18	RNA	RNA	NNP
cord-318495-1w74wf02	288	19	results	result	NNS
cord-318495-1w74wf02	288	20	in	in	IN
cord-318495-1w74wf02	288	21	leukemic	leukemic	JJ
cord-318495-1w74wf02	288	22	cell	cell	NN
cord-318495-1w74wf02	288	23	differentiation	differentiation	NN
cord-318495-1w74wf02	288	24	and	and	CC
cord-318495-1w74wf02	288	25	apoptosis	apoptosis	NN
cord-318495-1w74wf02	288	26	Ebola	Ebola	NNP
cord-318495-1w74wf02	288	27	virus	virus	NN
cord-318495-1w74wf02	288	28	defective	defective	JJ
cord-318495-1w74wf02	288	29	interfering	interfere	VBG
cord-318495-1w74wf02	288	30	particles	particle	NNS
cord-318495-1w74wf02	288	31	and	and	CC
cord-318495-1w74wf02	288	32	persistent	persistent	JJ
cord-318495-1w74wf02	288	33	infection	infection	NN
cord-318495-1w74wf02	288	34	Defective	defective	JJ
cord-318495-1w74wf02	288	35	interfering	interfere	VBG
cord-318495-1w74wf02	288	36	viral	viral	JJ
cord-318495-1w74wf02	288	37	particles	particle	NNS
cord-318495-1w74wf02	288	38	in	in	IN
cord-318495-1w74wf02	288	39	acute	acute	JJ
cord-318495-1w74wf02	288	40	dengue	dengue	NN
cord-318495-1w74wf02	288	41	infections	infection	NNS
cord-318495-1w74wf02	288	42	Generation	generation	NN
cord-318495-1w74wf02	288	43	of	of	IN
cord-318495-1w74wf02	288	44	measles	measle	NNS
cord-318495-1w74wf02	288	45	virus	virus	NN
cord-318495-1w74wf02	288	46	defective	defective	JJ
cord-318495-1w74wf02	288	47	interfering	interfere	VBG
cord-318495-1w74wf02	288	48	particles	particle	NNS
cord-318495-1w74wf02	288	49	and	and	CC
cord-318495-1w74wf02	288	50	their	-PRON-	PRP$
cord-318495-1w74wf02	288	51	presence	presence	NN
cord-318495-1w74wf02	288	52	in	in	IN
cord-318495-1w74wf02	288	53	a	a	DT
cord-318495-1w74wf02	288	54	preparation	preparation	NN
cord-318495-1w74wf02	288	55	of	of	IN
cord-318495-1w74wf02	288	56	attenuated	attenuated	JJ
cord-318495-1w74wf02	288	57	live	live	JJ
cord-318495-1w74wf02	288	58	-	-	HYPH
cord-318495-1w74wf02	288	59	virus	virus	NN
cord-318495-1w74wf02	288	60	vaccine	vaccine	NN
cord-318495-1w74wf02	288	61	Effects	effect	NNS
cord-318495-1w74wf02	288	62	of	of	IN
cord-318495-1w74wf02	288	63	defective	defective	JJ
cord-318495-1w74wf02	288	64	interfering	interfere	VBG
cord-318495-1w74wf02	288	65	viruses	virus	NNS
cord-318495-1w74wf02	288	66	on	on	IN
cord-318495-1w74wf02	288	67	virus	virus	NN
cord-318495-1w74wf02	288	68	replication	replication	NN
cord-318495-1w74wf02	288	69	and	and	CC
cord-318495-1w74wf02	288	70	pathogenesis	pathogenesis	NN
cord-318495-1w74wf02	288	71	in	in	IN
cord-318495-1w74wf02	288	72	vitro	vitro	FW
cord-318495-1w74wf02	288	73	and	and	CC
cord-318495-1w74wf02	288	74	in	in	IN
cord-318495-1w74wf02	288	75	vivo	vivo	NN
cord-318495-1w74wf02	288	76	Defective	defective	JJ
cord-318495-1w74wf02	288	77	interfering	interfere	VBG
cord-318495-1w74wf02	288	78	particles	particle	NNS
cord-318495-1w74wf02	288	79	of	of	IN
cord-318495-1w74wf02	288	80	respiratory	respiratory	JJ
cord-318495-1w74wf02	288	81	syncytial	syncytial	JJ
cord-318495-1w74wf02	288	82	virus	virus	NN
cord-318495-1w74wf02	288	83	Induction	induction	NN
cord-318495-1w74wf02	288	84	and	and	CC
cord-318495-1w74wf02	288	85	biological	biological	JJ
cord-318495-1w74wf02	288	86	properties	property	NNS
cord-318495-1w74wf02	288	87	of	of	IN
cord-318495-1w74wf02	288	88	defective	defective	JJ
cord-318495-1w74wf02	288	89	interfering	interfere	VBG
cord-318495-1w74wf02	288	90	particles	particle	NNS
cord-318495-1w74wf02	288	91	of	of	IN
cord-318495-1w74wf02	288	92	rabies	rabies	NN
cord-318495-1w74wf02	288	93	virus	virus	NN
cord-318495-1w74wf02	288	94	Defective	defective	JJ
cord-318495-1w74wf02	288	95	T	T	NNP
cord-318495-1w74wf02	288	96	particles	particle	NNS
cord-318495-1w74wf02	288	97	of	of	IN
cord-318495-1w74wf02	288	98	vesicular	vesicular	JJ
cord-318495-1w74wf02	288	99	stomatitis	stomatitis	NN
cord-318495-1w74wf02	288	100	virus	virus	NN
cord-318495-1w74wf02	288	101	.	.	.
cord-318495-1w74wf02	289	1	II	II	NNP
cord-318495-1w74wf02	289	2	.	.	.
cord-318495-1w74wf02	290	1	Biologic	biologic	JJ
cord-318495-1w74wf02	290	2	role	role	NN
cord-318495-1w74wf02	290	3	in	in	IN
cord-318495-1w74wf02	290	4	homologous	homologous	JJ
cord-318495-1w74wf02	290	5	interference	interference	NN
cord-318495-1w74wf02	290	6	Viral	viral	JJ
cord-318495-1w74wf02	290	7	interference	interference	NN
cord-318495-1w74wf02	290	8	by	by	IN
cord-318495-1w74wf02	290	9	defective	defective	JJ
cord-318495-1w74wf02	290	10	particles	particle	NNS
cord-318495-1w74wf02	290	11	of	of	IN
cord-318495-1w74wf02	290	12	vesicular	vesicular	JJ
cord-318495-1w74wf02	290	13	stomatitis	stomatitis	NN
cord-318495-1w74wf02	290	14	virus	virus	NN
cord-318495-1w74wf02	290	15	measured	measure	VBN
cord-318495-1w74wf02	290	16	in	in	IN
cord-318495-1w74wf02	290	17	individual	individual	JJ
cord-318495-1w74wf02	290	18	cells	cell	NNS
cord-318495-1w74wf02	290	19	Analysis	Analysis	NNP
cord-318495-1w74wf02	290	20	of	of	IN
cord-318495-1w74wf02	290	21	extracellular	extracellular	JJ
cord-318495-1w74wf02	290	22	West	West	NNP
cord-318495-1w74wf02	290	23	Nile	Nile	NNP
cord-318495-1w74wf02	290	24	virus	virus	NN
cord-318495-1w74wf02	290	25	particles	particle	NNS
cord-318495-1w74wf02	290	26	produced	produce	VBN
cord-318495-1w74wf02	290	27	by	by	IN
cord-318495-1w74wf02	290	28	cell	cell	NN
cord-318495-1w74wf02	290	29	cultures	culture	NNS
cord-318495-1w74wf02	290	30	from	from	IN
cord-318495-1w74wf02	290	31	genetically	genetically	RB
cord-318495-1w74wf02	290	32	resistant	resistant	JJ
cord-318495-1w74wf02	290	33	and	and	CC
cord-318495-1w74wf02	290	34	susceptible	susceptible	JJ
cord-318495-1w74wf02	290	35	mice	mouse	NNS
cord-318495-1w74wf02	290	36	indicates	indicate	VBZ
cord-318495-1w74wf02	290	37	enhanced	enhance	VBN
cord-318495-1w74wf02	290	38	amplification	amplification	NN
cord-318495-1w74wf02	290	39	of	of	IN
cord-318495-1w74wf02	290	40	defective	defective	JJ
cord-318495-1w74wf02	290	41	interfering	interfere	VBG
cord-318495-1w74wf02	290	42	particles	particle	NNS
cord-318495-1w74wf02	290	43	by	by	IN
cord-318495-1w74wf02	290	44	resistant	resistant	JJ
cord-318495-1w74wf02	290	45	cultures	culture	NNS
cord-318495-1w74wf02	290	46	Replication	replication	NN
cord-318495-1w74wf02	290	47	signals	signal	NNS
cord-318495-1w74wf02	290	48	in	in	IN
cord-318495-1w74wf02	290	49	the	the	DT
cord-318495-1w74wf02	290	50	genome	genome	NN
cord-318495-1w74wf02	290	51	of	of	IN
cord-318495-1w74wf02	290	52	vesicular	vesicular	JJ
cord-318495-1w74wf02	290	53	stoma	stoma	NN
cord-318495-1w74wf02	290	54	titis	titis	NNP
cord-318495-1w74wf02	290	55	virus	virus	NN
cord-318495-1w74wf02	290	56	and	and	CC
cord-318495-1w74wf02	290	57	its	-PRON-	PRP$
cord-318495-1w74wf02	290	58	defective	defective	JJ
cord-318495-1w74wf02	290	59	interfering	interfere	VBG
cord-318495-1w74wf02	290	60	particles	particle	NNS
cord-318495-1w74wf02	290	61	:	:	:
cord-318495-1w74wf02	290	62	identification	identification	NN
cord-318495-1w74wf02	290	63	of	of	IN
cord-318495-1w74wf02	290	64	a	a	DT
cord-318495-1w74wf02	290	65	sequence	sequence	NN
cord-318495-1w74wf02	290	66	element	element	NN
cord-318495-1w74wf02	290	67	that	that	WDT
cord-318495-1w74wf02	290	68	enhances	enhance	VBZ
cord-318495-1w74wf02	290	69	DI	DI	NNP
cord-318495-1w74wf02	290	70	RNA	RNA	NNP
cord-318495-1w74wf02	290	71	replication	replication	NN
cord-318495-1w74wf02	290	72	Functional	functional	JJ
cord-318495-1w74wf02	290	73	characterisation	characterisation	NN
cord-318495-1w74wf02	290	74	of	of	IN
cord-318495-1w74wf02	290	75	the	the	DT
cord-318495-1w74wf02	290	76	genomic	genomic	JJ
cord-318495-1w74wf02	290	77	and	and	CC
cord-318495-1w74wf02	290	78	antigenomic	antigenomic	JJ
cord-318495-1w74wf02	290	79	promoters	promoter	NNS
cord-318495-1w74wf02	290	80	of	of	IN
cord-318495-1w74wf02	290	81	Sendai	Sendai	NNP
cord-318495-1w74wf02	290	82	virus	virus	NN
cord-318495-1w74wf02	290	83	Homologous	homologous	JJ
cord-318495-1w74wf02	290	84	interference	interference	NN
cord-318495-1w74wf02	290	85	by	by	IN
cord-318495-1w74wf02	290	86	incomplete	incomplete	JJ
cord-318495-1w74wf02	290	87	Sendai	Sendai	NNP
cord-318495-1w74wf02	290	88	virus	virus	NN
cord-318495-1w74wf02	290	89	particles	particle	NNS
cord-318495-1w74wf02	290	90	:	:	:
cord-318495-1w74wf02	290	91	changes	change	NNS
cord-318495-1w74wf02	290	92	in	in	IN
cord-318495-1w74wf02	290	93	virus	virus	NN
cord-318495-1w74wf02	290	94	-	-	HYPH
cord-318495-1w74wf02	290	95	specific	specific	JJ
cord-318495-1w74wf02	290	96	ribonucleic	ribonucleic	NN
cord-318495-1w74wf02	290	97	acid	acid	NN
cord-318495-1w74wf02	290	98	synthesis	synthesis	NN
cord-318495-1w74wf02	290	99	Defective	defective	JJ
cord-318495-1w74wf02	290	100	viral	viral	JJ
cord-318495-1w74wf02	290	101	genomes	genome	NNS
cord-318495-1w74wf02	290	102	alter	alter	VBP
cord-318495-1w74wf02	290	103	how	how	WRB
cord-318495-1w74wf02	290	104	Sendai	Sendai	NNP
cord-318495-1w74wf02	290	105	virus	virus	NN
cord-318495-1w74wf02	290	106	interacts	interact	VBZ
cord-318495-1w74wf02	290	107	with	with	IN
cord-318495-1w74wf02	290	108	cellular	cellular	JJ
cord-318495-1w74wf02	290	109	trafficking	traffic	VBG
cord-318495-1w74wf02	290	110	machinery	machinery	NN
cord-318495-1w74wf02	290	111	leading	lead	VBG
cord-318495-1w74wf02	290	112	to	to	IN
cord-318495-1w74wf02	290	113	heterogeneity	heterogeneity	NN
cord-318495-1w74wf02	290	114	in	in	IN
cord-318495-1w74wf02	290	115	the	the	DT
cord-318495-1w74wf02	290	116	production	production	NN
cord-318495-1w74wf02	290	117	of	of	IN
cord-318495-1w74wf02	290	118	viral	viral	JJ
cord-318495-1w74wf02	290	119	particles	particle	NNS
cord-318495-1w74wf02	290	120	among	among	IN
cord-318495-1w74wf02	290	121	infected	infected	JJ
cord-318495-1w74wf02	290	122	cells	cell	NNS
cord-318495-1w74wf02	290	123	Replication	replication	NN
cord-318495-1w74wf02	290	124	defective	defective	JJ
cord-318495-1w74wf02	290	125	viral	viral	JJ
cord-318495-1w74wf02	290	126	genomes	genome	NNS
cord-318495-1w74wf02	290	127	exploit	exploit	VBP
cord-318495-1w74wf02	290	128	a	a	DT
cord-318495-1w74wf02	290	129	cellular	cellular	JJ
cord-318495-1w74wf02	290	130	pro	pro	JJ
cord-318495-1w74wf02	290	131	-	-	JJ
cord-318495-1w74wf02	290	132	survival	survival	JJ
cord-318495-1w74wf02	290	133	mechanism	mechanism	NN
cord-318495-1w74wf02	290	134	to	to	TO
cord-318495-1w74wf02	290	135	establish	establish	VB
cord-318495-1w74wf02	290	136	paramyxovirus	paramyxovirus	JJ
cord-318495-1w74wf02	290	137	persistence	persistence	NN
cord-318495-1w74wf02	290	138	MDA5	MDA5	NNP
cord-318495-1w74wf02	290	139	participates	participate	VBZ
cord-318495-1w74wf02	290	140	in	in	IN
cord-318495-1w74wf02	290	141	the	the	DT
cord-318495-1w74wf02	290	142	detection	detection	NN
cord-318495-1w74wf02	290	143	of	of	IN
cord-318495-1w74wf02	290	144	paramyxovirus	paramyxovirus	JJ
cord-318495-1w74wf02	290	145	infection	infection	NN
cord-318495-1w74wf02	290	146	and	and	CC
cord-318495-1w74wf02	290	147	is	be	VBZ
cord-318495-1w74wf02	290	148	essential	essential	JJ
cord-318495-1w74wf02	290	149	for	for	IN
cord-318495-1w74wf02	290	150	the	the	DT
cord-318495-1w74wf02	290	151	early	early	JJ
cord-318495-1w74wf02	290	152	activation	activation	NN
cord-318495-1w74wf02	290	153	of	of	IN
cord-318495-1w74wf02	290	154	dendritic	dendritic	JJ
cord-318495-1w74wf02	290	155	cells	cell	NNS
cord-318495-1w74wf02	290	156	in	in	IN
cord-318495-1w74wf02	290	157	response	response	NN
cord-318495-1w74wf02	290	158	to	to	IN
cord-318495-1w74wf02	290	159	Sendai	Sendai	NNP
cord-318495-1w74wf02	290	160	virus	virus	NN
cord-318495-1w74wf02	290	161	defective	defective	JJ
cord-318495-1w74wf02	290	162	interfering	interfere	VBG
cord-318495-1w74wf02	290	163	particles	particle	NNS
cord-318495-1w74wf02	290	164	Sendai	Sendai	NNP
cord-318495-1w74wf02	290	165	virus	virus	NN
cord-318495-1w74wf02	290	166	defective	defective	JJ
cord-318495-1w74wf02	290	167	-	-	HYPH
cord-318495-1w74wf02	290	168	interfering	interfere	VBG
cord-318495-1w74wf02	290	169	genomes	genome	NNS
cord-318495-1w74wf02	290	170	and	and	CC
cord-318495-1w74wf02	290	171	the	the	DT
cord-318495-1w74wf02	290	172	activation	activation	NN
cord-318495-1w74wf02	290	173	of	of	IN
cord-318495-1w74wf02	290	174	interferon	interferon	NN
cord-318495-1w74wf02	290	175	-	-	HYPH
cord-318495-1w74wf02	290	176	beta	beta	NN
cord-318495-1w74wf02	290	177	Induction	Induction	NNP
cord-318495-1w74wf02	290	178	of	of	IN
cord-318495-1w74wf02	290	179	dendritic	dendritic	JJ
cord-318495-1w74wf02	290	180	cell	cell	NN
cord-318495-1w74wf02	290	181	production	production	NN
cord-318495-1w74wf02	290	182	of	of	IN
cord-318495-1w74wf02	290	183	type	type	NN
cord-318495-1w74wf02	290	184	I	-PRON-	PRP
cord-318495-1w74wf02	290	185	and	and	CC
cord-318495-1w74wf02	290	186	type	type	NN
cord-318495-1w74wf02	290	187	III	iii	CD
cord-318495-1w74wf02	290	188	interferons	interferon	NNS
cord-318495-1w74wf02	290	189	by	by	IN
cord-318495-1w74wf02	290	190	wild	wild	JJ
cord-318495-1w74wf02	290	191	-	-	HYPH
cord-318495-1w74wf02	290	192	type	type	NN
cord-318495-1w74wf02	290	193	and	and	CC
cord-318495-1w74wf02	290	194	vaccine	vaccine	NN
cord-318495-1w74wf02	290	195	strains	strain	NNS
cord-318495-1w74wf02	290	196	of	of	IN
cord-318495-1w74wf02	290	197	measles	measle	NNS
cord-318495-1w74wf02	290	198	virus	virus	NN
cord-318495-1w74wf02	290	199	:	:	:
cord-318495-1w74wf02	290	200	role	role	NN
cord-318495-1w74wf02	290	201	of	of	IN
cord-318495-1w74wf02	290	202	defective	defective	JJ
cord-318495-1w74wf02	290	203	interfering	interfere	VBG
cord-318495-1w74wf02	290	204	RNAs	rna	NNS
cord-318495-1w74wf02	290	205	Highly	highly	RB
cord-318495-1w74wf02	290	206	immunostimulatory	immunostimulatory	NNP
cord-318495-1w74wf02	290	207	RNA	RNA	NNP
cord-318495-1w74wf02	290	208	derived	derive	VBD
cord-318495-1w74wf02	290	209	from	from	IN
cord-318495-1w74wf02	290	210	a	a	DT
cord-318495-1w74wf02	290	211	Sendai	Sendai	NNP
cord-318495-1w74wf02	290	212	virus	virus	NN
cord-318495-1w74wf02	290	213	defective	defective	JJ
cord-318495-1w74wf02	290	214	viral	viral	JJ
cord-318495-1w74wf02	290	215	genome	genome	NN
cord-318495-1w74wf02	291	1	A	a	DT
cord-318495-1w74wf02	291	2	novel	novel	JJ
cord-318495-1w74wf02	291	3	role	role	NN
cord-318495-1w74wf02	291	4	for	for	IN
cord-318495-1w74wf02	291	5	viral	viral	JJ
cord-318495-1w74wf02	291	6	-	-	HYPH
cord-318495-1w74wf02	291	7	defective	defective	JJ
cord-318495-1w74wf02	291	8	interfering	interfere	VBG
cord-318495-1w74wf02	291	9	particles	particle	NNS
cord-318495-1w74wf02	291	10	in	in	IN
cord-318495-1w74wf02	291	11	enhancing	enhance	VBG
cord-318495-1w74wf02	291	12	dendritic	dendritic	JJ
cord-318495-1w74wf02	291	13	cell	cell	NN
cord-318495-1w74wf02	291	14	maturation	maturation	NN
cord-318495-1w74wf02	291	15	Modulation	modulation	NN
cord-318495-1w74wf02	291	16	of	of	IN
cord-318495-1w74wf02	291	17	a	a	DT
cord-318495-1w74wf02	291	18	systemic	systemic	JJ
cord-318495-1w74wf02	291	19	Semliki	Semliki	NNP
cord-318495-1w74wf02	291	20	Forest	Forest	NNP
cord-318495-1w74wf02	291	21	virus	virus	NN
cord-318495-1w74wf02	291	22	infection	infection	NN
cord-318495-1w74wf02	291	23	in	in	IN
cord-318495-1w74wf02	291	24	mice	mouse	NNS
cord-318495-1w74wf02	291	25	by	by	IN
cord-318495-1w74wf02	291	26	defective	defective	JJ
cord-318495-1w74wf02	291	27	interfering	interfere	VBG
cord-318495-1w74wf02	291	28	virus	virus	NN
cord-318495-1w74wf02	291	29	Identification	identification	NN
cord-318495-1w74wf02	291	30	of	of	IN
cord-318495-1w74wf02	291	31	a	a	DT
cord-318495-1w74wf02	291	32	natural	natural	JJ
cord-318495-1w74wf02	291	33	viral	viral	JJ
cord-318495-1w74wf02	291	34	RNA	RNA	NNP
cord-318495-1w74wf02	291	35	motif	motif	NN
cord-318495-1w74wf02	291	36	that	that	WDT
cord-318495-1w74wf02	291	37	optimizes	optimize	VBZ
cord-318495-1w74wf02	291	38	sensing	sensing	NN
cord-318495-1w74wf02	291	39	of	of	IN
cord-318495-1w74wf02	291	40	viral	viral	JJ
cord-318495-1w74wf02	291	41	RNA	RNA	NNP
cord-318495-1w74wf02	291	42	by	by	IN
cord-318495-1w74wf02	291	43	RIG.-I.	RIG.-I.	NNP
cord-318495-1w74wf02	291	44	mBio	mBio	NNP
cord-318495-1w74wf02	291	45	Activation	Activation	NNP
cord-318495-1w74wf02	291	46	of	of	IN
cord-318495-1w74wf02	291	47	the	the	DT
cord-318495-1w74wf02	291	48	beta	beta	NN
cord-318495-1w74wf02	291	49	interferon	interferon	NN
cord-318495-1w74wf02	291	50	promoter	promoter	NN
cord-318495-1w74wf02	291	51	by	by	IN
cord-318495-1w74wf02	291	52	unnatural	unnatural	JJ
cord-318495-1w74wf02	291	53	Sendai	Sendai	NNP
cord-318495-1w74wf02	291	54	virus	virus	NN
cord-318495-1w74wf02	291	55	infection	infection	NN
cord-318495-1w74wf02	291	56	requires	require	VBZ
cord-318495-1w74wf02	291	57	RIG	rig	NN
cord-318495-1w74wf02	291	58	-	-	:
cord-318495-1w74wf02	291	59	I	i	NN
cord-318495-1w74wf02	291	60	and	and	CC
cord-318495-1w74wf02	291	61	is	be	VBZ
cord-318495-1w74wf02	291	62	inhibited	inhibit	VBN
cord-318495-1w74wf02	291	63	by	by	IN
cord-318495-1w74wf02	291	64	viral	viral	JJ
cord-318495-1w74wf02	291	65	C	c	NN
cord-318495-1w74wf02	291	66	proteins	protein	NNS
cord-318495-1w74wf02	291	67	PACT	PACT	NNP
cord-318495-1w74wf02	291	68	-	-	:
cord-318495-1w74wf02	291	69	and	and	CC
cord-318495-1w74wf02	291	70	RIG	rig	NN
cord-318495-1w74wf02	291	71	-	-	HYPH
cord-318495-1w74wf02	291	72	I	i	NN
cord-318495-1w74wf02	291	73	-	-	HYPH
cord-318495-1w74wf02	291	74	dependent	dependent	JJ
cord-318495-1w74wf02	291	75	activation	activation	NN
cord-318495-1w74wf02	291	76	of	of	IN
cord-318495-1w74wf02	291	77	Type	type	NN
cord-318495-1w74wf02	291	78	I	-PRON-	PRP
cord-318495-1w74wf02	291	79	interferon	interferon	VBD
cord-318495-1w74wf02	291	80	production	production	NN
cord-318495-1w74wf02	291	81	by	by	IN
cord-318495-1w74wf02	291	82	a	a	DT
cord-318495-1w74wf02	291	83	defective	defective	JJ
cord-318495-1w74wf02	291	84	interfering	interfere	VBG
cord-318495-1w74wf02	291	85	RNA	RNA	NNP
cord-318495-1w74wf02	291	86	derived	derive	VBN
cord-318495-1w74wf02	291	87	from	from	IN
cord-318495-1w74wf02	291	88	measles	measles	NNP
cord-318495-1w74wf02	291	89	virus	virus	NN
cord-318495-1w74wf02	291	90	vaccine	vaccine	NN
cord-318495-1w74wf02	291	91	Preference	Preference	NNP
cord-318495-1w74wf02	291	92	of	of	IN
cord-318495-1w74wf02	291	93	RIG	rig	NN
cord-318495-1w74wf02	291	94	-	-	:
cord-318495-1w74wf02	291	95	I	-PRON-	PRP
cord-318495-1w74wf02	291	96	for	for	IN
cord-318495-1w74wf02	291	97	short	short	JJ
cord-318495-1w74wf02	291	98	viral	viral	JJ
cord-318495-1w74wf02	291	99	RNA	RNA	NNP
cord-318495-1w74wf02	291	100	molecules	molecule	NNS
cord-318495-1w74wf02	291	101	in	in	IN
cord-318495-1w74wf02	291	102	infected	infected	JJ
cord-318495-1w74wf02	291	103	cells	cell	NNS
cord-318495-1w74wf02	291	104	revealed	reveal	VBN
cord-318495-1w74wf02	291	105	by	by	IN
cord-318495-1w74wf02	291	106	next	next	JJ
cord-318495-1w74wf02	291	107	-	-	HYPH
cord-318495-1w74wf02	291	108	generation	generation	NN
cord-318495-1w74wf02	291	109	sequencing	sequencing	NN
cord-318495-1w74wf02	291	110	TLR	tlr	NN
cord-318495-1w74wf02	291	111	-	-	HYPH
cord-318495-1w74wf02	291	112	independent	independent	JJ
cord-318495-1w74wf02	291	113	induction	induction	NN
cord-318495-1w74wf02	291	114	of	of	IN
cord-318495-1w74wf02	291	115	dendritic	dendritic	JJ
cord-318495-1w74wf02	291	116	cell	cell	NN
cord-318495-1w74wf02	291	117	maturation	maturation	NN
cord-318495-1w74wf02	291	118	and	and	CC
cord-318495-1w74wf02	291	119	adaptive	adaptive	JJ
cord-318495-1w74wf02	291	120	immunity	immunity	NN
cord-318495-1w74wf02	291	121	by	by	IN
cord-318495-1w74wf02	291	122	negative	negative	JJ
cord-318495-1w74wf02	291	123	-	-	HYPH
cord-318495-1w74wf02	291	124	strand	strand	NN
cord-318495-1w74wf02	291	125	RNA	RNA	NNP
cord-318495-1w74wf02	291	126	viruses	virus	NNS
cord-318495-1w74wf02	292	1	In	in	IN
cord-318495-1w74wf02	292	2	vivo	vivo	NN
cord-318495-1w74wf02	292	3	ligands	ligand	NNS
cord-318495-1w74wf02	292	4	of	of	IN
cord-318495-1w74wf02	292	5	MDA5	MDA5	NNP
cord-318495-1w74wf02	292	6	and	and	CC
cord-318495-1w74wf02	292	7	RIG	rig	NN
cord-318495-1w74wf02	293	1	-I	-i	WDT
cord-318495-1w74wf02	293	2	in	in	IN
cord-318495-1w74wf02	293	3	measles	measle	NNS
cord-318495-1w74wf02	293	4	virusinfected	virusinfecte	VBN
cord-318495-1w74wf02	293	5	cells	cell	NNS
cord-318495-1w74wf02	294	1	Nonencapsidated	nonencapsidated	JJ
cord-318495-1w74wf02	294	2	5′	5′	CD
cord-318495-1w74wf02	294	3	Copy	copy	VB
cord-318495-1w74wf02	294	4	-	-	HYPH
cord-318495-1w74wf02	294	5	Back	back	NN
cord-318495-1w74wf02	294	6	Defective	defective	JJ
cord-318495-1w74wf02	294	7	Interfering	interfering	NN
cord-318495-1w74wf02	294	8	Genomes	Genomes	NNPS
cord-318495-1w74wf02	294	9	Produced	produce	VBN
cord-318495-1w74wf02	294	10	by	by	IN
cord-318495-1w74wf02	294	11	Recombinant	Recombinant	NNP
cord-318495-1w74wf02	294	12	Measles	Measles	NNP
cord-318495-1w74wf02	294	13	Viruses	virus	NNS
cord-318495-1w74wf02	294	14	Are	be	VBP
cord-318495-1w74wf02	294	15	Recognized	recognize	VBN
cord-318495-1w74wf02	294	16	by	by	IN
cord-318495-1w74wf02	294	17	RIG	rig	NN
cord-318495-1w74wf02	294	18	-	-	:
cord-318495-1w74wf02	294	19	I	I	NNP
cord-318495-1w74wf02	294	20	and	and	CC
cord-318495-1w74wf02	294	21	LGP2	LGP2	NNP
cord-318495-1w74wf02	294	22	but	but	CC
cord-318495-1w74wf02	294	23	Not	not	RB
cord-318495-1w74wf02	294	24	MDA5	MDA5	NNP
cord-318495-1w74wf02	294	25	ATPase	ATPase	NNP
cord-318495-1w74wf02	294	26	-	-	HYPH
cord-318495-1w74wf02	294	27	driven	drive	VBN
cord-318495-1w74wf02	294	28	oligomerization	oligomerization	NN
cord-318495-1w74wf02	294	29	of	of	IN
cord-318495-1w74wf02	294	30	RIG	rig	NN
cord-318495-1w74wf02	294	31	-	-	:
cord-318495-1w74wf02	294	32	I	-PRON-	PRP
cord-318495-1w74wf02	294	33	on	on	IN
cord-318495-1w74wf02	294	34	RNA	RNA	NNP
cord-318495-1w74wf02	294	35	allows	allow	VBZ
cord-318495-1w74wf02	294	36	optimal	optimal	JJ
cord-318495-1w74wf02	294	37	activation	activation	NN
cord-318495-1w74wf02	294	38	of	of	IN
cord-318495-1w74wf02	294	39	type	type	NN
cord-318495-1w74wf02	294	40	-	-	:
cord-318495-1w74wf02	294	41	I	-PRON-	PRP
cord-318495-1w74wf02	294	42	interferon	interferon	VBD
cord-318495-1w74wf02	294	43	Double	double	RB
cord-318495-1w74wf02	294	44	-	-	HYPH
cord-318495-1w74wf02	294	45	stranded	strand	VBN
cord-318495-1w74wf02	294	46	RNA	RNA	NNP
cord-318495-1w74wf02	294	47	is	be	VBZ
cord-318495-1w74wf02	294	48	produced	produce	VBN
cord-318495-1w74wf02	294	49	by	by	IN
cord-318495-1w74wf02	294	50	positive	positive	JJ
cord-318495-1w74wf02	294	51	-	-	HYPH
cord-318495-1w74wf02	294	52	strand	strand	NN
cord-318495-1w74wf02	294	53	RNA	RNA	NNP
cord-318495-1w74wf02	294	54	viruses	virus	NNS
cord-318495-1w74wf02	294	55	and	and	CC
cord-318495-1w74wf02	294	56	DNA	dna	NN
cord-318495-1w74wf02	294	57	viruses	virus	NNS
cord-318495-1w74wf02	294	58	but	but	CC
cord-318495-1w74wf02	294	59	not	not	RB
cord-318495-1w74wf02	294	60	in	in	IN
cord-318495-1w74wf02	294	61	detectable	detectable	JJ
cord-318495-1w74wf02	294	62	amounts	amount	NNS
cord-318495-1w74wf02	294	63	by	by	IN
cord-318495-1w74wf02	294	64	negative	negative	JJ
cord-318495-1w74wf02	294	65	-	-	HYPH
cord-318495-1w74wf02	294	66	strand	strand	NN
cord-318495-1w74wf02	294	67	RNA	RNA	NNP
cord-318495-1w74wf02	294	68	viruses	virus	NNS
cord-318495-1w74wf02	294	69	Dicer-2-dependent	dicer-2-dependent	JJ
cord-318495-1w74wf02	294	70	generation	generation	NN
cord-318495-1w74wf02	294	71	of	of	IN
cord-318495-1w74wf02	294	72	viral	viral	JJ
cord-318495-1w74wf02	294	73	DNA	dna	NN
cord-318495-1w74wf02	294	74	from	from	IN
cord-318495-1w74wf02	294	75	defective	defective	JJ
cord-318495-1w74wf02	294	76	genomes	genome	NNS
cord-318495-1w74wf02	294	77	of	of	IN
cord-318495-1w74wf02	294	78	RNA	RNA	NNP
cord-318495-1w74wf02	294	79	viruses	virus	NNS
cord-318495-1w74wf02	294	80	modulates	modulate	VBZ
cord-318495-1w74wf02	294	81	antiviral	antiviral	JJ
cord-318495-1w74wf02	294	82	immunity	immunity	NN
cord-318495-1w74wf02	294	83	in	in	IN
cord-318495-1w74wf02	294	84	insects	insect	NNS
cord-318495-1w74wf02	294	85	Role	role	NN
cord-318495-1w74wf02	294	86	of	of	IN
cord-318495-1w74wf02	294	87	defective	defective	JJ
cord-318495-1w74wf02	294	88	interfering	interfere	VBG
cord-318495-1w74wf02	294	89	particles	particle	NNS
cord-318495-1w74wf02	294	90	of	of	IN
cord-318495-1w74wf02	294	91	Sendai	Sendai	NNP
cord-318495-1w74wf02	294	92	virus	virus	NN
cord-318495-1w74wf02	294	93	in	in	IN
cord-318495-1w74wf02	294	94	persistent	persistent	JJ
cord-318495-1w74wf02	294	95	infections	infection	NNS
cord-318495-1w74wf02	295	1	Comparative	comparative	JJ
cord-318495-1w74wf02	295	2	study	study	NN
cord-318495-1w74wf02	295	3	of	of	IN
cord-318495-1w74wf02	295	4	rabies	rabies	NN
cord-318495-1w74wf02	295	5	virus	virus	NN
cord-318495-1w74wf02	295	6	persistence	persistence	NN
cord-318495-1w74wf02	295	7	in	in	IN
cord-318495-1w74wf02	295	8	human	human	JJ
cord-318495-1w74wf02	295	9	and	and	CC
cord-318495-1w74wf02	295	10	hamster	hamster	NN
cord-318495-1w74wf02	295	11	cell	cell	NN
cord-318495-1w74wf02	295	12	lines	line	NNS
cord-318495-1w74wf02	295	13	Subclinical	Subclinical	NNP
cord-318495-1w74wf02	295	14	infections	infection	NNS
cord-318495-1w74wf02	295	15	in	in	IN
cord-318495-1w74wf02	295	16	mice	mouse	NNS
cord-318495-1w74wf02	295	17	resulting	result	VBG
cord-318495-1w74wf02	295	18	from	from	IN
cord-318495-1w74wf02	295	19	the	the	DT
cord-318495-1w74wf02	295	20	modulation	modulation	NN
cord-318495-1w74wf02	295	21	of	of	IN
cord-318495-1w74wf02	295	22	a	a	DT
cord-318495-1w74wf02	295	23	lethal	lethal	JJ
cord-318495-1w74wf02	295	24	dose	dose	NN
cord-318495-1w74wf02	295	25	of	of	IN
cord-318495-1w74wf02	295	26	Semliki	Semliki	NNP
cord-318495-1w74wf02	295	27	Forest	Forest	NNP
cord-318495-1w74wf02	295	28	virus	virus	NN
cord-318495-1w74wf02	295	29	with	with	IN
cord-318495-1w74wf02	295	30	defective	defective	JJ
cord-318495-1w74wf02	295	31	interfering	interfere	VBG
cord-318495-1w74wf02	295	32	viruses	virus	NNS
cord-318495-1w74wf02	295	33	:	:	:
cord-318495-1w74wf02	296	1	neurochemical	neurochemical	JJ
cord-318495-1w74wf02	296	2	abnormalities	abnormality	NNS
cord-318495-1w74wf02	296	3	in	in	IN
cord-318495-1w74wf02	296	4	the	the	DT
cord-318495-1w74wf02	296	5	central	central	JJ
cord-318495-1w74wf02	296	6	nervous	nervous	JJ
cord-318495-1w74wf02	296	7	system	system	NN
cord-318495-1w74wf02	296	8	Defective	defective	JJ
cord-318495-1w74wf02	296	9	interfering	interfere	VBG
cord-318495-1w74wf02	296	10	particles	particle	NNS
cord-318495-1w74wf02	296	11	:	:	:
cord-318495-1w74wf02	296	12	effects	effect	NNS
cord-318495-1w74wf02	296	13	in	in	IN
cord-318495-1w74wf02	296	14	modulating	modulate	VBG
cord-318495-1w74wf02	296	15	virus	virus	NN
cord-318495-1w74wf02	296	16	growth	growth	NN
cord-318495-1w74wf02	296	17	and	and	CC
cord-318495-1w74wf02	296	18	persistence	persistence	NN
cord-318495-1w74wf02	296	19	Persistence	persistence	NN
cord-318495-1w74wf02	296	20	of	of	IN
cord-318495-1w74wf02	296	21	virulent	virulent	JJ
cord-318495-1w74wf02	296	22	Semliki	Semliki	NNP
cord-318495-1w74wf02	296	23	Forest	Forest	NNP
cord-318495-1w74wf02	296	24	virus	virus	NN
cord-318495-1w74wf02	296	25	in	in	IN
cord-318495-1w74wf02	296	26	mouse	mouse	NN
cord-318495-1w74wf02	296	27	brain	brain	NN
cord-318495-1w74wf02	296	28	following	follow	VBG
cord-318495-1w74wf02	296	29	co	co	NN
cord-318495-1w74wf02	296	30	-	-	NN
cord-318495-1w74wf02	296	31	inoculation	inoculation	NN
cord-318495-1w74wf02	296	32	with	with	IN
cord-318495-1w74wf02	296	33	defective	defective	JJ
cord-318495-1w74wf02	296	34	interfering	interfere	VBG
cord-318495-1w74wf02	296	35	particles	particle	NNS
cord-318495-1w74wf02	296	36	Defective	defective	JJ
cord-318495-1w74wf02	296	37	interfering	interfere	VBG
cord-318495-1w74wf02	296	38	virus	virus	NN
cord-318495-1w74wf02	296	39	particles	particle	NNS
cord-318495-1w74wf02	296	40	modulate	modulate	VBP
cord-318495-1w74wf02	296	41	virulence	virulence	NN
cord-318495-1w74wf02	296	42	Continuous	continuous	JJ
cord-318495-1w74wf02	296	43	influenza	influenza	NN
cord-318495-1w74wf02	296	44	virus	virus	NN
cord-318495-1w74wf02	296	45	production	production	NN
cord-318495-1w74wf02	296	46	in	in	IN
cord-318495-1w74wf02	296	47	cell	cell	NN
cord-318495-1w74wf02	296	48	culture	culture	NN
cord-318495-1w74wf02	296	49	shows	show	VBZ
cord-318495-1w74wf02	296	50	a	a	DT
cord-318495-1w74wf02	296	51	periodic	periodic	JJ
cord-318495-1w74wf02	296	52	accumulation	accumulation	NN
cord-318495-1w74wf02	296	53	of	of	IN
cord-318495-1w74wf02	296	54	defective	defective	JJ
cord-318495-1w74wf02	296	55	interfering	interfere	VBG
cord-318495-1w74wf02	296	56	particles	particle	NNS
cord-318495-1w74wf02	296	57	Multiple	multiple	JJ
cord-318495-1w74wf02	296	58	-	-	HYPH
cord-318495-1w74wf02	296	59	hit	hit	VBN
cord-318495-1w74wf02	296	60	inhibition	inhibition	NN
cord-318495-1w74wf02	296	61	of	of	IN
cord-318495-1w74wf02	296	62	infection	infection	NN
cord-318495-1w74wf02	296	63	by	by	IN
cord-318495-1w74wf02	296	64	defective	defective	JJ
cord-318495-1w74wf02	296	65	interfering	interfere	VBG
cord-318495-1w74wf02	296	66	particles	particle	NNS
cord-318495-1w74wf02	296	67	Defective	defective	JJ
cord-318495-1w74wf02	296	68	interfering	interfere	VBG
cord-318495-1w74wf02	296	69	particles	particle	NNS
cord-318495-1w74wf02	296	70	of	of	IN
cord-318495-1w74wf02	296	71	human	human	JJ
cord-318495-1w74wf02	296	72	parainfluenza	parainfluenza	NNP
cord-318495-1w74wf02	296	73	virus	virus	NNP
cord-318495-1w74wf02	296	74	type	type	NNP
cord-318495-1w74wf02	296	75	3	3	CD
cord-318495-1w74wf02	296	76	are	be	VBP
cord-318495-1w74wf02	296	77	associated	associate	VBN
cord-318495-1w74wf02	296	78	with	with	IN
cord-318495-1w74wf02	296	79	persistent	persistent	JJ
cord-318495-1w74wf02	296	80	infection	infection	NN
cord-318495-1w74wf02	296	81	in	in	IN
cord-318495-1w74wf02	296	82	cell	cell	NN
cord-318495-1w74wf02	296	83	culture	culture	NN
cord-318495-1w74wf02	296	84	Defective	defective	JJ
cord-318495-1w74wf02	296	85	interfering	interfere	VBG
cord-318495-1w74wf02	296	86	influenza	influenza	NN
cord-318495-1w74wf02	296	87	virus	virus	NN
cord-318495-1w74wf02	296	88	RNAs	rna	NNS
cord-318495-1w74wf02	296	89	:	:	:
cord-318495-1w74wf02	296	90	time	time	NN
cord-318495-1w74wf02	296	91	to	to	TO
cord-318495-1w74wf02	296	92	reevaluate	reevaluate	VB
cord-318495-1w74wf02	296	93	their	-PRON-	PRP$
cord-318495-1w74wf02	296	94	clinical	clinical	JJ
cord-318495-1w74wf02	296	95	potential	potential	NN
cord-318495-1w74wf02	296	96	as	as	IN
cord-318495-1w74wf02	296	97	broad	broad	JJ
cord-318495-1w74wf02	296	98	-	-	HYPH
cord-318495-1w74wf02	296	99	spectrum	spectrum	NN
cord-318495-1w74wf02	296	100	antivirals	antiviral	NNS
cord-318495-1w74wf02	296	101	?	?	.
cord-318495-1w74wf02	297	1	Targeting	target	VBG
cord-318495-1w74wf02	297	2	pattern	pattern	NN
cord-318495-1w74wf02	297	3	recognition	recognition	NN
cord-318495-1w74wf02	297	4	receptors	receptor	NNS
cord-318495-1w74wf02	297	5	(	(	-LRB-
cord-318495-1w74wf02	297	6	PRR	PRR	NNP
cord-318495-1w74wf02	297	7	)	)	-RRB-
cord-318495-1w74wf02	297	8	for	for	IN
cord-318495-1w74wf02	297	9	vaccine	vaccine	NN
cord-318495-1w74wf02	297	10	adjuvantation	adjuvantation	NN
cord-318495-1w74wf02	297	11	:	:	:
cord-318495-1w74wf02	297	12	from	from	IN
cord-318495-1w74wf02	297	13	synthetic	synthetic	JJ
cord-318495-1w74wf02	297	14	PRR	PRR	NNP
cord-318495-1w74wf02	297	15	agonists	agonist	NNS
cord-318495-1w74wf02	297	16	to	to	IN
cord-318495-1w74wf02	297	17	the	the	DT
cord-318495-1w74wf02	297	18	potential	potential	NN
cord-318495-1w74wf02	297	19	of	of	IN
cord-318495-1w74wf02	297	20	defective	defective	JJ
cord-318495-1w74wf02	297	21	interfering	interfere	VBG
cord-318495-1w74wf02	297	22	particles	particle	NNS
cord-318495-1w74wf02	297	23	of	of	IN
cord-318495-1w74wf02	297	24	viruses	virus	NNS
cord-318495-1w74wf02	297	25	Accumulation	Accumulation	NNP
cord-318495-1w74wf02	297	26	of	of	IN
cord-318495-1w74wf02	297	27	defective	defective	JJ
cord-318495-1w74wf02	297	28	interfering	interfere	VBG
cord-318495-1w74wf02	297	29	viral	viral	JJ
cord-318495-1w74wf02	297	30	particles	particle	NNS
cord-318495-1w74wf02	297	31	in	in	IN
cord-318495-1w74wf02	297	32	only	only	RB
cord-318495-1w74wf02	297	33	a	a	DT
cord-318495-1w74wf02	297	34	few	few	JJ
cord-318495-1w74wf02	297	35	passages	passage	NNS
cord-318495-1w74wf02	297	36	in	in	IN
cord-318495-1w74wf02	297	37	Vero	Vero	NNP
cord-318495-1w74wf02	297	38	cells	cell	NNS
cord-318495-1w74wf02	297	39	attenuates	attenuate	VBZ
cord-318495-1w74wf02	297	40	mumps	mumps	NN
cord-318495-1w74wf02	297	41	virus	virus	NN
cord-318495-1w74wf02	297	42	neurovirulence	neurovirulence	NNP
cord-318495-1w74wf02	298	1	In	in	IN
cord-318495-1w74wf02	298	2	vivo	vivo	NN
cord-318495-1w74wf02	298	3	antiviral	antiviral	JJ
cord-318495-1w74wf02	298	4	activity	activity	NN
cord-318495-1w74wf02	298	5	:	:	:
cord-318495-1w74wf02	298	6	defective	defective	JJ
cord-318495-1w74wf02	298	7	interfering	interfere	VBG
cord-318495-1w74wf02	298	8	virus	virus	NN
cord-318495-1w74wf02	298	9	protects	protect	VBZ
cord-318495-1w74wf02	298	10	better	well	RBR
cord-318495-1w74wf02	298	11	against	against	IN
cord-318495-1w74wf02	298	12	virulent	virulent	JJ
cord-318495-1w74wf02	298	13	Influenza	Influenza	NNP
cord-318495-1w74wf02	298	14	A	a	DT
cord-318495-1w74wf02	298	15	virus	virus	NN
cord-318495-1w74wf02	298	16	than	than	IN
cord-318495-1w74wf02	298	17	avirulent	avirulent	JJ
cord-318495-1w74wf02	298	18	virus	virus	NN
cord-318495-1w74wf02	298	19	Interfering	interfere	VBG
cord-318495-1w74wf02	298	20	vaccine	vaccine	NN
cord-318495-1w74wf02	298	21	(	(	-LRB-
cord-318495-1w74wf02	298	22	defective	defective	JJ
cord-318495-1w74wf02	298	23	interfering	interfere	VBG
cord-318495-1w74wf02	298	24	influenza	influenza	NN
cord-318495-1w74wf02	298	25	A	a	DT
cord-318495-1w74wf02	298	26	virus	virus	NN
cord-318495-1w74wf02	298	27	)	)	-RRB-
cord-318495-1w74wf02	298	28	protects	protect	VBZ
cord-318495-1w74wf02	298	29	ferrets	ferret	NNS
cord-318495-1w74wf02	298	30	from	from	IN
cord-318495-1w74wf02	298	31	influenza	influenza	NN
cord-318495-1w74wf02	298	32	,	,	,
cord-318495-1w74wf02	298	33	and	and	CC
cord-318495-1w74wf02	298	34	allows	allow	VBZ
cord-318495-1w74wf02	298	35	them	-PRON-	PRP
cord-318495-1w74wf02	298	36	to	to	TO
cord-318495-1w74wf02	298	37	develop	develop	VB
cord-318495-1w74wf02	298	38	solid	solid	JJ
cord-318495-1w74wf02	298	39	immunity	immunity	NN
cord-318495-1w74wf02	298	40	to	to	TO
cord-318495-1w74wf02	298	41	reinfection	reinfection	NN
cord-318495-1w74wf02	298	42	The	the	DT
cord-318495-1w74wf02	298	43	case	case	NN
cord-318495-1w74wf02	298	44	for	for	IN
cord-318495-1w74wf02	298	45	transmissible	transmissible	JJ
cord-318495-1w74wf02	298	46	antivirals	antiviral	NNS
cord-318495-1w74wf02	298	47	to	to	TO
cord-318495-1w74wf02	298	48	control	control	VB
cord-318495-1w74wf02	298	49	population	population	NN
cord-318495-1w74wf02	298	50	-	-	HYPH
cord-318495-1w74wf02	298	51	wide	wide	JJ
cord-318495-1w74wf02	298	52	infectious	infectious	JJ
cord-318495-1w74wf02	298	53	disease	disease	NN
cord-318495-1w74wf02	298	54	Conflicting	conflict	VBG
cord-318495-1w74wf02	298	55	selection	selection	NN
cord-318495-1w74wf02	298	56	pressures	pressure	NNS
cord-318495-1w74wf02	298	57	will	will	MD
cord-318495-1w74wf02	298	58	constrain	constrain	VB
cord-318495-1w74wf02	298	59	viral	viral	JJ
cord-318495-1w74wf02	298	60	escape	escape	NN
cord-318495-1w74wf02	298	61	from	from	IN
cord-318495-1w74wf02	298	62	interfering	interfere	VBG
cord-318495-1w74wf02	298	63	particles	particle	NNS
cord-318495-1w74wf02	298	64	:	:	:
cord-318495-1w74wf02	298	65	principles	principle	NNS
cord-318495-1w74wf02	298	66	for	for	IN
cord-318495-1w74wf02	298	67	designing	design	VBG
cord-318495-1w74wf02	298	68	resistance	resistance	NN
cord-318495-1w74wf02	298	69	-	-	HYPH
cord-318495-1w74wf02	298	70	proof	proof	JJ
cord-318495-1w74wf02	298	71	antivirals	antiviral	NNS
cord-318495-1w74wf02	299	1	A	a	DT
cord-318495-1w74wf02	299	2	Sendai	Sendai	NNP
cord-318495-1w74wf02	299	3	virus	virus	NN
cord-318495-1w74wf02	299	4	-	-	HYPH
cord-318495-1w74wf02	299	5	derived	derive	VBN
cord-318495-1w74wf02	299	6	RNA	RNA	NNP
cord-318495-1w74wf02	299	7	agonist	agonist	NN
cord-318495-1w74wf02	299	8	of	of	IN
cord-318495-1w74wf02	299	9	RIG	rig	NN
cord-318495-1w74wf02	299	10	-	-	:
cord-318495-1w74wf02	299	11	I	-PRON-	PRP
cord-318495-1w74wf02	299	12	as	as	IN
cord-318495-1w74wf02	299	13	a	a	DT
cord-318495-1w74wf02	299	14	virus	virus	NN
cord-318495-1w74wf02	299	15	vaccine	vaccine	NN
cord-318495-1w74wf02	299	16	adjuvant	adjuvant	NN
cord-318495-1w74wf02	300	1	Virus	virus	NN
cord-318495-1w74wf02	300	2	-	-	HYPH
cord-318495-1w74wf02	300	3	derived	derive	VBN
cord-318495-1w74wf02	300	4	immunostimulatory	immunostimulatory	NNP
cord-318495-1w74wf02	300	5	RNA	RNA	NNP
cord-318495-1w74wf02	300	6	induces	induce	VBZ
cord-318495-1w74wf02	300	7	type	type	NN
cord-318495-1w74wf02	301	1	I	-PRON-	PRP
cord-318495-1w74wf02	301	2	IFN	IFN	NNP
cord-318495-1w74wf02	301	3	-	-	HYPH
cord-318495-1w74wf02	301	4	dependent	dependent	JJ
cord-318495-1w74wf02	301	5	antibodies	antibody	NNS
cord-318495-1w74wf02	301	6	and	and	CC
cord-318495-1w74wf02	301	7	T	t	NN
cord-318495-1w74wf02	301	8	-	-	HYPH
cord-318495-1w74wf02	301	9	cell	cell	NN
cord-318495-1w74wf02	301	10	responses	response	NNS
cord-318495-1w74wf02	301	11	during	during	IN
cord-318495-1w74wf02	301	12	vaccination	vaccination	NN
cord-318495-1w74wf02	301	13	A	a	DT
cord-318495-1w74wf02	301	14	novel	novel	JJ
cord-318495-1w74wf02	301	15	broad	broad	JJ
cord-318495-1w74wf02	301	16	-	-	HYPH
cord-318495-1w74wf02	301	17	spectrum	spectrum	NN
cord-318495-1w74wf02	301	18	treatment	treatment	NN
cord-318495-1w74wf02	301	19	for	for	IN
cord-318495-1w74wf02	301	20	respiratory	respiratory	JJ
cord-318495-1w74wf02	301	21	virus	virus	NN
cord-318495-1w74wf02	301	22	infections	infection	NNS
cord-318495-1w74wf02	301	23	:	:	:
cord-318495-1w74wf02	301	24	influenza	influenza	NN
cord-318495-1w74wf02	301	25	-	-	HYPH
cord-318495-1w74wf02	301	26	based	base	VBN
cord-318495-1w74wf02	301	27	defective	defective	JJ
cord-318495-1w74wf02	301	28	interfering	interfere	VBG
cord-318495-1w74wf02	301	29	virus	virus	NN
cord-318495-1w74wf02	301	30	provides	provide	VBZ
cord-318495-1w74wf02	301	31	protection	protection	NN
cord-318495-1w74wf02	301	32	against	against	IN
cord-318495-1w74wf02	301	33	pneumovirus	pneumovirus	NNP
cord-318495-1w74wf02	301	34	infection	infection	NN
cord-318495-1w74wf02	301	35	in	in	IN
cord-318495-1w74wf02	301	36	vivo	vivo	NN
cord-318495-1w74wf02	301	37	Wide	wide	JJ
cord-318495-1w74wf02	301	38	occurrence	occurrence	NN
cord-318495-1w74wf02	301	39	of	of	IN
cord-318495-1w74wf02	301	40	measles	measle	NNS
cord-318495-1w74wf02	301	41	virus	virus	NN
cord-318495-1w74wf02	301	42	subgenomic	subgenomic	NNP
cord-318495-1w74wf02	301	43	RNAs	RNAs	NNPS
cord-318495-1w74wf02	301	44	in	in	IN
cord-318495-1w74wf02	301	45	attenuated	attenuated	JJ
cord-318495-1w74wf02	301	46	live	live	JJ
cord-318495-1w74wf02	301	47	-	-	HYPH
cord-318495-1w74wf02	301	48	virus	virus	NN
cord-318495-1w74wf02	301	49	vaccines	vaccine	NNS
cord-318495-1w74wf02	301	50	Defective	defective	JJ
cord-318495-1w74wf02	301	51	interfering	interfere	VBG
cord-318495-1w74wf02	301	52	particles	particle	NNS
cord-318495-1w74wf02	301	53	from	from	IN
cord-318495-1w74wf02	301	54	poliovirus	poliovirus	NN
cord-318495-1w74wf02	301	55	vaccine	vaccine	NN
cord-318495-1w74wf02	301	56	and	and	CC
cord-318495-1w74wf02	301	57	vaccine	vaccine	NN
cord-318495-1w74wf02	301	58	reference	reference	NN
cord-318495-1w74wf02	301	59	strains	strain	VBZ
cord-318495-1w74wf02	301	60	Propagation	propagation	NN
cord-318495-1w74wf02	301	61	and	and	CC
cord-318495-1w74wf02	301	62	characterization	characterization	NN
cord-318495-1w74wf02	301	63	of	of	IN
cord-318495-1w74wf02	301	64	influenza	influenza	NN
cord-318495-1w74wf02	301	65	virus	virus	NN
cord-318495-1w74wf02	301	66	stocks	stock	NNS
cord-318495-1w74wf02	301	67	that	that	WDT
cord-318495-1w74wf02	301	68	lack	lack	VBP
cord-318495-1w74wf02	301	69	high	high	JJ
cord-318495-1w74wf02	301	70	levels	level	NNS
cord-318495-1w74wf02	301	71	of	of	IN
cord-318495-1w74wf02	301	72	defective	defective	JJ
cord-318495-1w74wf02	301	73	viral	viral	JJ
cord-318495-1w74wf02	301	74	genomes	genome	NNS
cord-318495-1w74wf02	301	75	and	and	CC
cord-318495-1w74wf02	301	76	hemagglutinin	hemagglutinin	NN
cord-318495-1w74wf02	301	77	mutations	mutation	NNS
cord-318495-1w74wf02	301	78	Live	live	RB
cord-318495-1w74wf02	302	1	attenuated	attenuated	JJ
cord-318495-1w74wf02	302	2	influenza	influenza	NN
cord-318495-1w74wf02	302	3	vaccine	vaccine	NN
cord-318495-1w74wf02	302	4	contains	contain	VBZ
cord-318495-1w74wf02	302	5	substantial	substantial	JJ
cord-318495-1w74wf02	302	6	and	and	CC
cord-318495-1w74wf02	302	7	unexpected	unexpected	JJ
cord-318495-1w74wf02	302	8	amounts	amount	NNS
cord-318495-1w74wf02	302	9	of	of	IN
cord-318495-1w74wf02	302	10	defective	defective	JJ
cord-318495-1w74wf02	302	11	viral	viral	JJ
cord-318495-1w74wf02	302	12	genomic	genomic	NN
cord-318495-1w74wf02	302	13	RNA	RNA	NNP
cord-318495-1w74wf02	302	14	Stochastic	stochastic	JJ
cord-318495-1w74wf02	302	15	processes	process	NNS
cord-318495-1w74wf02	302	16	constrain	constrain	VBP
cord-318495-1w74wf02	302	17	the	the	DT
cord-318495-1w74wf02	302	18	within	within	JJ
cord-318495-1w74wf02	302	19	and	and	CC
cord-318495-1w74wf02	302	20	between	between	IN
cord-318495-1w74wf02	302	21	host	host	NN
cord-318495-1w74wf02	302	22	evolution	evolution	NN
cord-318495-1w74wf02	302	23	of	of	IN
cord-318495-1w74wf02	302	24	influenza	influenza	NN
cord-318495-1w74wf02	302	25	virus	virus	NN
cord-318495-1w74wf02	303	1	Paramyxovirus	paramyxovirus	JJ
cord-318495-1w74wf02	303	2	ultrastructure	ultrastructure	NN
cord-318495-1w74wf02	303	3	and	and	CC
cord-318495-1w74wf02	303	4	genome	genome	NN
cord-318495-1w74wf02	303	5	packaging	packaging	NN
cord-318495-1w74wf02	303	6	:	:	:
cord-318495-1w74wf02	304	1	cryo	cryo	NN
cord-318495-1w74wf02	304	2	-	-	HYPH
cord-318495-1w74wf02	304	3	electron	electron	NN
cord-318495-1w74wf02	304	4	tomography	tomography	NN
cord-318495-1w74wf02	304	5	of	of	IN
cord-318495-1w74wf02	304	6	sendai	sendai	NNP
cord-318495-1w74wf02	304	7	virus	virus	NN
cord-318495-1w74wf02	304	8	Multi	Multi	NNP
cord-318495-1w74wf02	304	9	-	-	JJ
cord-318495-1w74wf02	304	10	virion	virion	NN
cord-318495-1w74wf02	304	11	infectious	infectious	JJ
cord-318495-1w74wf02	304	12	units	unit	NNS
cord-318495-1w74wf02	304	13	arise	arise	VBP
cord-318495-1w74wf02	304	14	from	from	IN
cord-318495-1w74wf02	304	15	free	free	JJ
cord-318495-1w74wf02	304	16	viral	viral	JJ
cord-318495-1w74wf02	304	17	particles	particle	NNS
cord-318495-1w74wf02	304	18	in	in	IN
cord-318495-1w74wf02	304	19	an	an	DT
cord-318495-1w74wf02	304	20	enveloped	envelop	VBN
cord-318495-1w74wf02	304	21	virus	virus	NN
cord-318495-1w74wf02	304	22	Plaques	plaque	NNS
cord-318495-1w74wf02	304	23	formed	form	VBN
cord-318495-1w74wf02	304	24	by	by	IN
cord-318495-1w74wf02	304	25	mutagenized	mutagenized	JJ
cord-318495-1w74wf02	304	26	viral	viral	JJ
cord-318495-1w74wf02	304	27	populations	population	NNS
cord-318495-1w74wf02	304	28	have	have	VBP
cord-318495-1w74wf02	304	29	elevated	elevate	VBN
cord-318495-1w74wf02	304	30	coinfection	coinfection	NN
cord-318495-1w74wf02	304	31	frequencies	frequency	NNS
cord-318495-1w74wf02	304	32	Modeling	model	VBG
cord-318495-1w74wf02	304	33	the	the	DT
cord-318495-1w74wf02	304	34	intracellular	intracellular	JJ
cord-318495-1w74wf02	304	35	replication	replication	NN
cord-318495-1w74wf02	304	36	of	of	IN
cord-318495-1w74wf02	304	37	influenza	influenza	NN
cord-318495-1w74wf02	304	38	A	a	DT
cord-318495-1w74wf02	304	39	virus	virus	NN
cord-318495-1w74wf02	304	40	in	in	IN
cord-318495-1w74wf02	304	41	the	the	DT
cord-318495-1w74wf02	304	42	presence	presence	NN
cord-318495-1w74wf02	304	43	of	of	IN
cord-318495-1w74wf02	304	44	defective	defective	JJ
cord-318495-1w74wf02	304	45	interfering	interfere	VBG
cord-318495-1w74wf02	304	46	RNAs	rna	NNS
cord-318495-1w74wf02	304	47	Design	design	NN
cord-318495-1w74wf02	304	48	requirements	requirement	NNS
cord-318495-1w74wf02	304	49	for	for	IN
cord-318495-1w74wf02	304	50	interfering	interfere	VBG
cord-318495-1w74wf02	304	51	particles	particle	NNS
cord-318495-1w74wf02	304	52	to	to	TO
cord-318495-1w74wf02	304	53	maintain	maintain	VB
cord-318495-1w74wf02	304	54	coadaptive	coadaptive	JJ
cord-318495-1w74wf02	304	55	stability	stability	NN
cord-318495-1w74wf02	304	56	with	with	IN
cord-318495-1w74wf02	304	57	HIV-1	HIV-1	NNP
cord-318495-1w74wf02	304	58	Genetic	Genetic	NNP
cord-318495-1w74wf02	304	59	analysis	analysis	NN
cord-318495-1w74wf02	304	60	of	of	IN
cord-318495-1w74wf02	304	61	serum	serum	NN
cord-318495-1w74wf02	304	62	-	-	HYPH
cord-318495-1w74wf02	304	63	derived	derive	VBN
cord-318495-1w74wf02	304	64	defective	defective	JJ
cord-318495-1w74wf02	304	65	Hepatitis	Hepatitis	NNP
cord-318495-1w74wf02	304	66	C	C	NNP
cord-318495-1w74wf02	304	67	virus	virus	NN
cord-318495-1w74wf02	304	68	genomes	genome	NNS
cord-318495-1w74wf02	304	69	revealed	reveal	VBD
cord-318495-1w74wf02	304	70	novel	novel	JJ
cord-318495-1w74wf02	304	71	viral	viral	JJ
cord-318495-1w74wf02	304	72	cis	cis	NNP
cord-318495-1w74wf02	304	73	elements	element	NNS
cord-318495-1w74wf02	304	74	for	for	IN
cord-318495-1w74wf02	304	75	virus	virus	NN
cord-318495-1w74wf02	304	76	replication	replication	NN
cord-318495-1w74wf02	304	77	and	and	CC
cord-318495-1w74wf02	304	78	assembly	assembly	NN
cord-318495-1w74wf02	304	79	Identification	Identification	NNP
cord-318495-1w74wf02	304	80	of	of	IN
cord-318495-1w74wf02	304	81	new	new	JJ
cord-318495-1w74wf02	304	82	defective	defective	JJ
cord-318495-1w74wf02	304	83	interfering	interfere	VBG
cord-318495-1w74wf02	304	84	RNA	RNA	NNP
cord-318495-1w74wf02	304	85	species	specie	NNS
cord-318495-1w74wf02	304	86	associated	associate	VBN
cord-318495-1w74wf02	304	87	with	with	IN
cord-318495-1w74wf02	304	88	porcine	porcine	JJ
cord-318495-1w74wf02	304	89	reproductive	reproductive	JJ
cord-318495-1w74wf02	304	90	and	and	CC
cord-318495-1w74wf02	304	91	respiratory	respiratory	JJ
cord-318495-1w74wf02	304	92	syndrome	syndrome	NN
cord-318495-1w74wf02	304	93	virus	virus	NN
cord-318495-1w74wf02	304	94	infection	infection	NN
cord-318495-1w74wf02	304	95	Multiple	multiple	JJ
cord-318495-1w74wf02	304	96	species	specie	NNS
cord-318495-1w74wf02	304	97	of	of	IN
cord-318495-1w74wf02	304	98	defective	defective	JJ
cord-318495-1w74wf02	304	99	RNAs	rna	NNS
cord-318495-1w74wf02	304	100	in	in	IN
cord-318495-1w74wf02	304	101	plants	plant	NNS
cord-318495-1w74wf02	304	102	infected	infect	VBN
cord-318495-1w74wf02	304	103	with	with	IN
cord-318495-1w74wf02	304	104	citrus	citrus	NNP
cord-318495-1w74wf02	304	105	tristeza	tristeza	NNP
cord-318495-1w74wf02	304	106	virus	virus	NN
cord-318495-1w74wf02	304	107	A	a	DT
cord-318495-1w74wf02	304	108	novel	novel	JJ
cord-318495-1w74wf02	304	109	class	class	NN
cord-318495-1w74wf02	304	110	of	of	IN
cord-318495-1w74wf02	304	111	large	large	JJ
cord-318495-1w74wf02	304	112	and	and	CC
cord-318495-1w74wf02	304	113	infectious	infectious	JJ
cord-318495-1w74wf02	304	114	defective	defective	JJ
cord-318495-1w74wf02	304	115	RNAs	rna	NNS
cord-318495-1w74wf02	304	116	of	of	IN
cord-318495-1w74wf02	304	117	Citrus	Citrus	NNP
cord-318495-1w74wf02	304	118	tristeza	tristeza	NNP
cord-318495-1w74wf02	304	119	virus	virus	NN
cord-318495-1w74wf02	304	120	Characterization	characterization	NN
cord-318495-1w74wf02	304	121	of	of	IN
cord-318495-1w74wf02	304	122	defective	defective	JJ
cord-318495-1w74wf02	304	123	interfering	interfere	VBG
cord-318495-1w74wf02	304	124	RNAs	rna	NNS
cord-318495-1w74wf02	304	125	of	of	IN
cord-318495-1w74wf02	304	126	Berne	Berne	NNP
cord-318495-1w74wf02	304	127	virus	virus	NN
cord-318495-1w74wf02	305	1	Bovine	bovine	JJ
cord-318495-1w74wf02	305	2	coronavirus	coronavirus	NN
cord-318495-1w74wf02	306	1	mRNA	mRNA	NNP
cord-318495-1w74wf02	306	2	replication	replication	NN
cord-318495-1w74wf02	306	3	continues	continue	VBZ
cord-318495-1w74wf02	306	4	throughout	throughout	IN
cord-318495-1w74wf02	306	5	persistent	persistent	JJ
cord-318495-1w74wf02	306	6	infection	infection	NN
cord-318495-1w74wf02	306	7	in	in	IN
cord-318495-1w74wf02	306	8	cell	cell	NN
cord-318495-1w74wf02	306	9	culture	culture	NN
cord-318495-1w74wf02	306	10	Replication	replication	NN
cord-318495-1w74wf02	306	11	and	and	CC
cord-318495-1w74wf02	306	12	packaging	packaging	NN
cord-318495-1w74wf02	306	13	of	of	IN
cord-318495-1w74wf02	306	14	coronavirus	coronavirus	NN
cord-318495-1w74wf02	306	15	infectious	infectious	JJ
cord-318495-1w74wf02	306	16	bronchitis	bronchitis	NN
cord-318495-1w74wf02	306	17	virus	virus	NN
cord-318495-1w74wf02	306	18	defective	defective	JJ
cord-318495-1w74wf02	306	19	RNAs	rna	NNS
cord-318495-1w74wf02	306	20	lacking	lack	VBG
cord-318495-1w74wf02	306	21	a	a	DT
cord-318495-1w74wf02	306	22	long	long	JJ
cord-318495-1w74wf02	306	23	open	open	JJ
cord-318495-1w74wf02	306	24	reading	reading	NN
cord-318495-1w74wf02	306	25	frame	frame	NN
cord-318495-1w74wf02	306	26	Analysis	Analysis	NNP
cord-318495-1w74wf02	306	27	of	of	IN
cord-318495-1w74wf02	306	28	efficiently	efficiently	RB
cord-318495-1w74wf02	306	29	packaged	package	VBN
cord-318495-1w74wf02	306	30	defective	defective	JJ
cord-318495-1w74wf02	306	31	interfering	interfere	VBG
cord-318495-1w74wf02	306	32	RNAs	rna	NNS
cord-318495-1w74wf02	306	33	of	of	IN
cord-318495-1w74wf02	306	34	murine	murine	JJ
cord-318495-1w74wf02	306	35	coronavirus	coronavirus	NN
cord-318495-1w74wf02	306	36	:	:	:
cord-318495-1w74wf02	306	37	localization	localization	NN
cord-318495-1w74wf02	306	38	of	of	IN
cord-318495-1w74wf02	306	39	a	a	DT
cord-318495-1w74wf02	306	40	possible	possible	JJ
cord-318495-1w74wf02	306	41	RNA	rna	NN
cord-318495-1w74wf02	306	42	-	-	HYPH
cord-318495-1w74wf02	306	43	packaging	packaging	NN
cord-318495-1w74wf02	306	44	signal	signal	NN
cord-318495-1w74wf02	306	45	A	a	DT
cord-318495-1w74wf02	306	46	domain	domain	NN
cord-318495-1w74wf02	306	47	at	at	IN
cord-318495-1w74wf02	306	48	the	the	DT
cord-318495-1w74wf02	306	49	3′	3′	CD
cord-318495-1w74wf02	306	50	end	end	NN
cord-318495-1w74wf02	306	51	of	of	IN
cord-318495-1w74wf02	306	52	the	the	DT
cord-318495-1w74wf02	306	53	polymerase	polymerase	NN
cord-318495-1w74wf02	306	54	gene	gene	NN
cord-318495-1w74wf02	306	55	is	be	VBZ
cord-318495-1w74wf02	306	56	essential	essential	JJ
cord-318495-1w74wf02	306	57	for	for	IN
cord-318495-1w74wf02	306	58	encapsidation	encapsidation	NN
cord-318495-1w74wf02	306	59	of	of	IN
cord-318495-1w74wf02	306	60	coronavirus	coronavirus	NN
cord-318495-1w74wf02	306	61	defective	defective	JJ
cord-318495-1w74wf02	306	62	interfering	interfere	VBG
cord-318495-1w74wf02	306	63	RNAs	rna	NNS
cord-318495-1w74wf02	306	64	Molecular	molecular	JJ
cord-318495-1w74wf02	306	65	characterization	characterization	NN
cord-318495-1w74wf02	306	66	of	of	IN
cord-318495-1w74wf02	306	67	transmissible	transmissible	JJ
cord-318495-1w74wf02	306	68	gastroenteritis	gastroenteritis	NN
cord-318495-1w74wf02	306	69	coronavirus	coronavirus	NN
cord-318495-1w74wf02	306	70	defective	defective	JJ
cord-318495-1w74wf02	306	71	interfering	interfere	VBG
cord-318495-1w74wf02	306	72	genomes	genome	NNS
cord-318495-1w74wf02	306	73	:	:	:
cord-318495-1w74wf02	306	74	packaging	packaging	NN
cord-318495-1w74wf02	306	75	and	and	CC
cord-318495-1w74wf02	306	76	heterogeneity	heterogeneity	NN
cord-318495-1w74wf02	306	77	Long	long	JJ
cord-318495-1w74wf02	306	78	-	-	HYPH
cord-318495-1w74wf02	306	79	term	term	NN
cord-318495-1w74wf02	306	80	transmission	transmission	NN
cord-318495-1w74wf02	306	81	of	of	IN
cord-318495-1w74wf02	306	82	defective	defective	JJ
cord-318495-1w74wf02	306	83	RNA	RNA	NNP
cord-318495-1w74wf02	306	84	viruses	virus	NNS
cord-318495-1w74wf02	306	85	in	in	IN
cord-318495-1w74wf02	306	86	humans	human	NNS
cord-318495-1w74wf02	306	87	and	and	CC
cord-318495-1w74wf02	306	88	Aedes	Aedes	NNP
cord-318495-1w74wf02	306	89	mosquitoes	mosquitoe	VBZ
cord-318495-1w74wf02	306	90	Detection	detection	NN
cord-318495-1w74wf02	306	91	and	and	CC
cord-318495-1w74wf02	306	92	sequencing	sequencing	NN
cord-318495-1w74wf02	306	93	of	of	IN
cord-318495-1w74wf02	306	94	defective	defective	JJ
cord-318495-1w74wf02	306	95	viral	viral	JJ
cord-318495-1w74wf02	306	96	genomes	genome	NNS
cord-318495-1w74wf02	306	97	in	in	IN
cord-318495-1w74wf02	306	98	C6/36	C6/36	NNP
cord-318495-1w74wf02	306	99	cells	cell	NNS
cord-318495-1w74wf02	306	100	persistently	persistently	RB
cord-318495-1w74wf02	306	101	infected	infect	VBN
cord-318495-1w74wf02	306	102	with	with	IN
cord-318495-1w74wf02	306	103	dengue	dengue	NN
cord-318495-1w74wf02	306	104	virus	virus	NN
cord-318495-1w74wf02	306	105	2	2	CD
cord-318495-1w74wf02	306	106	Characterization	characterization	NN
cord-318495-1w74wf02	306	107	of	of	IN
cord-318495-1w74wf02	306	108	homologous	homologous	JJ
cord-318495-1w74wf02	306	109	defective	defective	JJ
cord-318495-1w74wf02	306	110	interfering	interfere	VBG
cord-318495-1w74wf02	306	111	RNA	RNA	NNP
cord-318495-1w74wf02	306	112	during	during	IN
cord-318495-1w74wf02	306	113	persistent	persistent	JJ
cord-318495-1w74wf02	306	114	infection	infection	NN
cord-318495-1w74wf02	306	115	of	of	IN
cord-318495-1w74wf02	306	116	Vero	Vero	NNP
cord-318495-1w74wf02	306	117	cells	cell	NNS
cord-318495-1w74wf02	306	118	with	with	IN
cord-318495-1w74wf02	306	119	Japanese	japanese	JJ
cord-318495-1w74wf02	306	120	encephalitis	encephalitis	RB
cord-318495-1w74wf02	306	121	virus	virus	NN
cord-318495-1w74wf02	306	122	Characterization	characterization	NN
cord-318495-1w74wf02	306	123	of	of	IN
cord-318495-1w74wf02	306	124	Hepatitis	Hepatitis	NNP
cord-318495-1w74wf02	306	125	C	C	NNP
cord-318495-1w74wf02	306	126	virus	virus	NN
cord-318495-1w74wf02	306	127	deletion	deletion	NN
cord-318495-1w74wf02	306	128	mutants	mutant	NNS
cord-318495-1w74wf02	306	129	circulating	circulate	VBG
cord-318495-1w74wf02	306	130	in	in	IN
cord-318495-1w74wf02	306	131	chronically	chronically	RB
cord-318495-1w74wf02	306	132	infected	infect	VBN
cord-318495-1w74wf02	306	133	patients	patient	NNS
cord-318495-1w74wf02	306	134	Naturally	naturally	RB
cord-318495-1w74wf02	306	135	occurring	occur	VBG
cord-318495-1w74wf02	306	136	Hepatitis	Hepatitis	NNP
cord-318495-1w74wf02	306	137	C	C	NNP
cord-318495-1w74wf02	306	138	virus	virus	NN
cord-318495-1w74wf02	306	139	subgenomic	subgenomic	JJ
cord-318495-1w74wf02	306	140	deletion	deletion	NN
cord-318495-1w74wf02	306	141	mutants	mutant	NNS
cord-318495-1w74wf02	306	142	replicate	replicate	VBP
cord-318495-1w74wf02	306	143	efficiently	efficiently	RB
cord-318495-1w74wf02	306	144	in	in	IN
cord-318495-1w74wf02	306	145	huh-7	huh-7	NNP
cord-318495-1w74wf02	306	146	Cells	cell	NNS
cord-318495-1w74wf02	306	147	and	and	CC
cord-318495-1w74wf02	306	148	are	be	VBP
cord-318495-1w74wf02	306	149	trans	trans	NNP
cord-318495-1w74wf02	306	150	-	-	VBN
cord-318495-1w74wf02	306	151	packaged	package	VBN
cord-318495-1w74wf02	306	152	in	in	IN
cord-318495-1w74wf02	306	153	vitro	vitro	FW
cord-318495-1w74wf02	306	154	to	to	TO
cord-318495-1w74wf02	306	155	generate	generate	VB
cord-318495-1w74wf02	306	156	infectious	infectious	JJ
cord-318495-1w74wf02	306	157	defective	defective	JJ
cord-318495-1w74wf02	306	158	particles	particle	NNS
cord-318495-1w74wf02	306	159	Characterization	characterization	NN
cord-318495-1w74wf02	306	160	of	of	IN
cord-318495-1w74wf02	306	161	defective	defective	JJ
cord-318495-1w74wf02	306	162	viral	viral	JJ
cord-318495-1w74wf02	306	163	RNA	RNA	NNP
cord-318495-1w74wf02	306	164	produced	produce	VBN
cord-318495-1w74wf02	306	165	during	during	IN
cord-318495-1w74wf02	306	166	persistent	persistent	JJ
cord-318495-1w74wf02	306	167	infection	infection	NN
cord-318495-1w74wf02	306	168	of	of	IN
cord-318495-1w74wf02	306	169	Vero	Vero	NNP
cord-318495-1w74wf02	306	170	cells	cell	NNS
cord-318495-1w74wf02	306	171	with	with	IN
cord-318495-1w74wf02	306	172	Murray	Murray	NNP
cord-318495-1w74wf02	306	173	Valley	Valley	NNP
cord-318495-1w74wf02	306	174	encephalitis	encephalitis	NN
cord-318495-1w74wf02	306	175	virus	virus	NN
cord-318495-1w74wf02	306	176	Spontaneous	spontaneous	JJ
cord-318495-1w74wf02	306	177	and	and	CC
cord-318495-1w74wf02	306	178	engineered	engineered	JJ
cord-318495-1w74wf02	306	179	deletions	deletion	NNS
cord-318495-1w74wf02	306	180	in	in	IN
cord-318495-1w74wf02	306	181	the	the	DT
cord-318495-1w74wf02	306	182	3′	3′	CD
cord-318495-1w74wf02	306	183	noncoding	noncoding	JJ
cord-318495-1w74wf02	306	184	region	region	NN
cord-318495-1w74wf02	306	185	of	of	IN
cord-318495-1w74wf02	306	186	tick	tick	NN
cord-318495-1w74wf02	306	187	-	-	HYPH
cord-318495-1w74wf02	306	188	borne	bear	VBN
cord-318495-1w74wf02	306	189	encephalitis	encephalitis	JJ
cord-318495-1w74wf02	306	190	virus	virus	NN
cord-318495-1w74wf02	306	191	:	:	:
cord-318495-1w74wf02	306	192	construction	construction	NN
cord-318495-1w74wf02	306	193	of	of	IN
cord-318495-1w74wf02	306	194	highly	highly	RB
cord-318495-1w74wf02	306	195	attenuated	attenuated	JJ
cord-318495-1w74wf02	306	196	mutants	mutant	NNS
cord-318495-1w74wf02	306	197	of	of	IN
cord-318495-1w74wf02	306	198	a	a	DT
cord-318495-1w74wf02	306	199	flavivirus	flavivirus	JJ
cord-318495-1w74wf02	306	200	Characterization	characterization	NN
cord-318495-1w74wf02	306	201	of	of	IN
cord-318495-1w74wf02	306	202	West	West	NNP
cord-318495-1w74wf02	306	203	Nile	Nile	NNP
cord-318495-1w74wf02	306	204	virus	virus	NN
cord-318495-1w74wf02	306	205	persistent	persistent	JJ
cord-318495-1w74wf02	306	206	infections	infection	NNS
cord-318495-1w74wf02	306	207	in	in	IN
cord-318495-1w74wf02	306	208	genetically	genetically	RB
cord-318495-1w74wf02	306	209	resistant	resistant	JJ
cord-318495-1w74wf02	306	210	and	and	CC
cord-318495-1w74wf02	306	211	susceptible	susceptible	JJ
cord-318495-1w74wf02	306	212	mouse	mouse	NN
cord-318495-1w74wf02	306	213	cells	cell	NNS
cord-318495-1w74wf02	306	214	.	.	.
cord-318495-1w74wf02	307	1	I.	I.	NNP
cord-318495-1w74wf02	307	2	Generation	Generation	NNP
cord-318495-1w74wf02	307	3	of	of	IN
cord-318495-1w74wf02	307	4	defective	defective	JJ
cord-318495-1w74wf02	307	5	nonplaquing	nonplaquing	JJ
cord-318495-1w74wf02	307	6	virus	virus	NN
cord-318495-1w74wf02	307	7	particles	particle	NNS
cord-318495-1w74wf02	307	8	Defective	Defective	NNP
cord-318495-1w74wf02	307	9	RNA	RNA	NNP
cord-318495-1w74wf02	307	10	particles	particle	NNS
cord-318495-1w74wf02	307	11	derived	derive	VBN
cord-318495-1w74wf02	307	12	from	from	IN
cord-318495-1w74wf02	307	13	Tomato	Tomato	NNP
cord-318495-1w74wf02	307	14	black	black	JJ
cord-318495-1w74wf02	307	15	ring	ring	NN
cord-318495-1w74wf02	307	16	virus	virus	NN
cord-318495-1w74wf02	307	17	genome	genome	NN
cord-318495-1w74wf02	307	18	interfere	interfere	VBP
cord-318495-1w74wf02	307	19	with	with	IN
cord-318495-1w74wf02	307	20	the	the	DT
cord-318495-1w74wf02	307	21	replication	replication	NN
cord-318495-1w74wf02	307	22	of	of	IN
cord-318495-1w74wf02	307	23	parental	parental	JJ
cord-318495-1w74wf02	307	24	virus	virus	NN
cord-318495-1w74wf02	308	1	Defective	defective	JJ
cord-318495-1w74wf02	308	2	interfering	interfere	VBG
cord-318495-1w74wf02	308	3	particles	particle	NNS
cord-318495-1w74wf02	308	4	of	of	IN
cord-318495-1w74wf02	308	5	encephalomyocarditis	encephalomyocarditis	NNP
cord-318495-1w74wf02	308	6	virus	virus	NN
cord-318495-1w74wf02	309	1	A	a	DT
cord-318495-1w74wf02	309	2	segmented	segmented	JJ
cord-318495-1w74wf02	309	3	form	form	NN
cord-318495-1w74wf02	309	4	of	of	IN
cord-318495-1w74wf02	309	5	foot	foot	NN
cord-318495-1w74wf02	309	6	-	-	HYPH
cord-318495-1w74wf02	309	7	and	and	CC
cord-318495-1w74wf02	309	8	-	-	HYPH
cord-318495-1w74wf02	309	9	mouth	mouth	NN
cord-318495-1w74wf02	309	10	disease	disease	NN
cord-318495-1w74wf02	309	11	virus	virus	NN
cord-318495-1w74wf02	309	12	interferes	interfere	VBZ
cord-318495-1w74wf02	309	13	with	with	IN
cord-318495-1w74wf02	309	14	standard	standard	JJ
cord-318495-1w74wf02	309	15	virus	virus	NN
cord-318495-1w74wf02	309	16	:	:	:
cord-318495-1w74wf02	309	17	a	a	DT
cord-318495-1w74wf02	309	18	link	link	NN
cord-318495-1w74wf02	309	19	between	between	IN
cord-318495-1w74wf02	309	20	interference	interference	NN
cord-318495-1w74wf02	309	21	and	and	CC
cord-318495-1w74wf02	309	22	competitive	competitive	JJ
cord-318495-1w74wf02	309	23	fitness	fitness	NN
cord-318495-1w74wf02	309	24	Generation	generation	NN
cord-318495-1w74wf02	309	25	of	of	IN
cord-318495-1w74wf02	309	26	defective	defective	JJ
cord-318495-1w74wf02	309	27	interfering	interfere	VBG
cord-318495-1w74wf02	309	28	particles	particle	NNS
cord-318495-1w74wf02	309	29	in	in	IN
cord-318495-1w74wf02	309	30	picornaviruses	picornaviruses	NNP
cord-318495-1w74wf02	309	31	Characterization	Characterization	NNP
cord-318495-1w74wf02	309	32	of	of	IN
cord-318495-1w74wf02	309	33	a	a	DT
cord-318495-1w74wf02	309	34	new	new	JJ
cord-318495-1w74wf02	309	35	isolate	isolate	NN
cord-318495-1w74wf02	309	36	of	of	IN
cord-318495-1w74wf02	309	37	poliovirus	poliovirus	NN
cord-318495-1w74wf02	309	38	defective	defective	JJ
cord-318495-1w74wf02	309	39	interfering	interfere	VBG
cord-318495-1w74wf02	309	40	particles	particle	NNS
cord-318495-1w74wf02	309	41	Characterization	characterization	NN
cord-318495-1w74wf02	309	42	of	of	IN
cord-318495-1w74wf02	309	43	defective	defective	JJ
cord-318495-1w74wf02	309	44	-	-	HYPH
cord-318495-1w74wf02	309	45	interfering	interfere	VBG
cord-318495-1w74wf02	309	46	RNAs	rna	NNS
cord-318495-1w74wf02	309	47	of	of	IN
cord-318495-1w74wf02	309	48	rubella	rubella	NN
cord-318495-1w74wf02	309	49	virus	virus	NN
cord-318495-1w74wf02	309	50	generated	generate	VBN
cord-318495-1w74wf02	309	51	during	during	IN
cord-318495-1w74wf02	309	52	serial	serial	JJ
cord-318495-1w74wf02	309	53	undiluted	undiluted	JJ
cord-318495-1w74wf02	309	54	passage	passage	NN
cord-318495-1w74wf02	309	55	Prevention	Prevention	NNP
cord-318495-1w74wf02	309	56	of	of	IN
cord-318495-1w74wf02	309	57	death	death	NN
cord-318495-1w74wf02	309	58	in	in	IN
cord-318495-1w74wf02	309	59	Semliki	Semliki	NNP
cord-318495-1w74wf02	309	60	Forest	Forest	NNP
cord-318495-1w74wf02	309	61	virus	virus	NN
cord-318495-1w74wf02	309	62	-	-	HYPH
cord-318495-1w74wf02	309	63	infected	infect	VBN
cord-318495-1w74wf02	309	64	mice	mouse	NNS
cord-318495-1w74wf02	309	65	by	by	IN
cord-318495-1w74wf02	309	66	administration	administration	NN
cord-318495-1w74wf02	309	67	of	of	IN
cord-318495-1w74wf02	309	68	defective	defective	JJ
cord-318495-1w74wf02	309	69	-	-	HYPH
cord-318495-1w74wf02	309	70	interfering	interfere	VBG
cord-318495-1w74wf02	309	71	Semliki	Semliki	NNP
cord-318495-1w74wf02	309	72	Forest	Forest	NNP
cord-318495-1w74wf02	309	73	virus	virus	NN
cord-318495-1w74wf02	309	74	Properties	Properties	NNP
cord-318495-1w74wf02	309	75	of	of	IN
cord-318495-1w74wf02	309	76	host	host	NN
cord-318495-1w74wf02	309	77	and	and	CC
cord-318495-1w74wf02	309	78	virus	virus	NN
cord-318495-1w74wf02	309	79	which	which	WDT
cord-318495-1w74wf02	309	80	influence	influence	VBP
cord-318495-1w74wf02	309	81	defective	defective	JJ
cord-318495-1w74wf02	309	82	interfering	interfere	VBG
cord-318495-1w74wf02	309	83	virus	virus	NN
cord-318495-1w74wf02	309	84	mediated	mediate	VBN
cord-318495-1w74wf02	309	85	-	-	HYPH
cord-318495-1w74wf02	309	86	protection	protection	NN
cord-318495-1w74wf02	309	87	of	of	IN
cord-318495-1w74wf02	309	88	mice	mouse	NNS
cord-318495-1w74wf02	309	89	against	against	IN
cord-318495-1w74wf02	309	90	Semliki	Semliki	NNP
cord-318495-1w74wf02	309	91	Forest	Forest	NNP
cord-318495-1w74wf02	309	92	virus	virus	NN
cord-318495-1w74wf02	310	1	lethal	lethal	JJ
cord-318495-1w74wf02	310	2	encephalitis	encephalitis	NN
cord-318495-1w74wf02	310	3	Sindbis	Sindbis	NNP
cord-318495-1w74wf02	310	4	virus	virus	NN
cord-318495-1w74wf02	310	5	:	:	:
cord-318495-1w74wf02	310	6	defective	defective	JJ
cord-318495-1w74wf02	310	7	-	-	HYPH
cord-318495-1w74wf02	310	8	interfering	interfere	VBG
cord-318495-1w74wf02	310	9	particles	particle	NNS
cord-318495-1w74wf02	310	10	temperature	temperature	NN
cord-318495-1w74wf02	310	11	-	-	HYPH
cord-318495-1w74wf02	310	12	sensitive	sensitive	JJ
cord-318495-1w74wf02	310	13	for	for	IN
cord-318495-1w74wf02	310	14	interferon	interferon	NN
cord-318495-1w74wf02	310	15	induction	induction	NN
cord-318495-1w74wf02	310	16	Sequence	sequence	NN
cord-318495-1w74wf02	310	17	and	and	CC
cord-318495-1w74wf02	310	18	structure	structure	NN
cord-318495-1w74wf02	310	19	of	of	IN
cord-318495-1w74wf02	310	20	defective	defective	JJ
cord-318495-1w74wf02	310	21	interfering	interfere	VBG
cord-318495-1w74wf02	310	22	RNAs	rna	NNS
cord-318495-1w74wf02	310	23	associated	associate	VBN
cord-318495-1w74wf02	310	24	with	with	IN
cord-318495-1w74wf02	310	25	cucumber	cucumber	NN
cord-318495-1w74wf02	310	26	necrosis	necrosis	NN
cord-318495-1w74wf02	310	27	virus	virus	NN
cord-318495-1w74wf02	310	28	infections	infection	NNS
cord-318495-1w74wf02	310	29	Turnip	Turnip	NNP
cord-318495-1w74wf02	310	30	crinkle	crinkle	NN
cord-318495-1w74wf02	310	31	virus	virus	NN
cord-318495-1w74wf02	310	32	defective	defective	JJ
cord-318495-1w74wf02	310	33	interfering	interfere	VBG
cord-318495-1w74wf02	310	34	RNAs	rna	NNS
cord-318495-1w74wf02	310	35	intensify	intensify	VBP
cord-318495-1w74wf02	310	36	viral	viral	JJ
cord-318495-1w74wf02	310	37	symptoms	symptom	NNS
cord-318495-1w74wf02	310	38	and	and	CC
cord-318495-1w74wf02	310	39	are	be	VBP
cord-318495-1w74wf02	310	40	generated	generate	VBN
cord-318495-1w74wf02	310	41	de	de	IN
cord-318495-1w74wf02	310	42	novo	novo	NNP
cord-318495-1w74wf02	310	43	Properties	Properties	NNP
cord-318495-1w74wf02	310	44	of	of	IN
cord-318495-1w74wf02	310	45	defective	defective	JJ
cord-318495-1w74wf02	310	46	lymphocytic	lymphocytic	JJ
cord-318495-1w74wf02	310	47	choriomeningitis	choriomeningitis	NN
cord-318495-1w74wf02	310	48	virus	virus	NN
cord-318495-1w74wf02	311	1	A	a	DT
cord-318495-1w74wf02	311	2	novel	novel	JJ
cord-318495-1w74wf02	311	3	type	type	NN
cord-318495-1w74wf02	311	4	of	of	IN
cord-318495-1w74wf02	311	5	defective	defective	JJ
cord-318495-1w74wf02	311	6	viral	viral	JJ
cord-318495-1w74wf02	311	7	genome	genome	NN
cord-318495-1w74wf02	311	8	suggests	suggest	VBZ
cord-318495-1w74wf02	311	9	a	a	DT
cord-318495-1w74wf02	311	10	unique	unique	JJ
cord-318495-1w74wf02	311	11	strategy	strategy	NN
cord-318495-1w74wf02	311	12	to	to	TO
cord-318495-1w74wf02	311	13	establish	establish	VB
cord-318495-1w74wf02	311	14	and	and	CC
cord-318495-1w74wf02	311	15	maintain	maintain	VB
cord-318495-1w74wf02	311	16	persistent	persistent	JJ
cord-318495-1w74wf02	311	17	lymphocytic	lymphocytic	JJ
cord-318495-1w74wf02	311	18	choriomeningitis	choriomeningitis	NNP
cord-318495-1w74wf02	311	19	virus	virus	NN
cord-318495-1w74wf02	311	20	infections	infection	NNS
cord-318495-1w74wf02	311	21	Interference	interference	NN
cord-318495-1w74wf02	311	22	between	between	IN
cord-318495-1w74wf02	311	23	inactive	inactive	JJ
cord-318495-1w74wf02	311	24	and	and	CC
cord-318495-1w74wf02	311	25	active	active	JJ
cord-318495-1w74wf02	311	26	influenza	influenza	NN
cord-318495-1w74wf02	311	27	viruses	virus	NNS
cord-318495-1w74wf02	311	28	in	in	IN
cord-318495-1w74wf02	311	29	the	the	DT
cord-318495-1w74wf02	311	30	chick	chick	NN
cord-318495-1w74wf02	311	31	embryo	embryo	NN
cord-318495-1w74wf02	311	32	.	.	.
cord-318495-1w74wf02	312	1	II	II	NNP
cord-318495-1w74wf02	312	2	.	.	.
cord-318495-1w74wf02	313	1	The	the	DT
cord-318495-1w74wf02	313	2	site	site	NN
cord-318495-1w74wf02	313	3	of	of	IN
cord-318495-1w74wf02	313	4	interference	interference	NN
cord-318495-1w74wf02	313	5	Influenza	Influenza	NNP
cord-318495-1w74wf02	313	6	virus	virus	NN
cord-318495-1w74wf02	313	7	nucleic	nucleic	VBD
cord-318495-1w74wf02	313	8	acid	acid	NN
cord-318495-1w74wf02	313	9	:	:	:
cord-318495-1w74wf02	313	10	relationship	relationship	NN
cord-318495-1w74wf02	313	11	between	between	IN
cord-318495-1w74wf02	313	12	biological	biological	JJ
cord-318495-1w74wf02	313	13	characteristics	characteristic	NNS
cord-318495-1w74wf02	313	14	of	of	IN
cord-318495-1w74wf02	313	15	the	the	DT
cord-318495-1w74wf02	313	16	virus	virus	NN
cord-318495-1w74wf02	313	17	particle	particle	NN
cord-318495-1w74wf02	313	18	and	and	CC
cord-318495-1w74wf02	313	19	properties	property	NNS
cord-318495-1w74wf02	313	20	of	of	IN
cord-318495-1w74wf02	313	21	the	the	DT
cord-318495-1w74wf02	313	22	nucleic	nucleic	JJ
cord-318495-1w74wf02	313	23	acid	acid	NN
cord-318495-1w74wf02	314	1	In	in	IN
cord-318495-1w74wf02	314	2	vitro	vitro	FW
cord-318495-1w74wf02	314	3	transcription	transcription	NN
cord-318495-1w74wf02	314	4	of	of	IN
cord-318495-1w74wf02	314	5	defective	defective	JJ
cord-318495-1w74wf02	314	6	interfering	interfere	VBG
cord-318495-1w74wf02	314	7	particles	particle	NNS
cord-318495-1w74wf02	314	8	of	of	IN
cord-318495-1w74wf02	314	9	influenza	influenza	NN
cord-318495-1w74wf02	314	10	virus	virus	NN
cord-318495-1w74wf02	314	11	produces	produce	VBZ
cord-318495-1w74wf02	314	12	polyadenylic	polyadenylic	JJ
cord-318495-1w74wf02	314	13	acid	acid	NN
cord-318495-1w74wf02	314	14	-	-	HYPH
cord-318495-1w74wf02	314	15	containing	contain	VBG
cord-318495-1w74wf02	314	16	complementary	complementary	JJ
cord-318495-1w74wf02	314	17	RNAs	rna	NNS
cord-318495-1w74wf02	314	18	Characterization	characterization	NN
cord-318495-1w74wf02	314	19	of	of	IN
cord-318495-1w74wf02	314	20	virulent	virulent	JJ
cord-318495-1w74wf02	314	21	and	and	CC
cord-318495-1w74wf02	314	22	avirulent	avirulent	JJ
cord-318495-1w74wf02	315	1	A	a	DT
cord-318495-1w74wf02	316	1	/chicken	/chicken	NNP
cord-318495-1w74wf02	316	2	/	/	SYM
cord-318495-1w74wf02	316	3	Pennsylvania/83	pennsylvania/83	CD
cord-318495-1w74wf02	316	4	influenza	influenza	NN
cord-318495-1w74wf02	316	5	A	a	DT
cord-318495-1w74wf02	316	6	viruses	virus	NNS
cord-318495-1w74wf02	316	7	:	:	:
cord-318495-1w74wf02	316	8	potential	potential	JJ
cord-318495-1w74wf02	316	9	role	role	NN
cord-318495-1w74wf02	316	10	of	of	IN
cord-318495-1w74wf02	316	11	defective	defective	JJ
cord-318495-1w74wf02	316	12	interfering	interfere	VBG
cord-318495-1w74wf02	316	13	RNAs	rna	NNS
cord-318495-1w74wf02	316	14	in	in	IN
cord-318495-1w74wf02	316	15	nature	nature	NN
cord-318495-1w74wf02	317	1	Defective	defective	JJ
cord-318495-1w74wf02	317	2	interfering	interfere	VBG
cord-318495-1w74wf02	317	3	virus	virus	NN
cord-318495-1w74wf02	317	4	associated	associate	VBN
cord-318495-1w74wf02	317	5	with	with	IN
cord-318495-1w74wf02	317	6	A	A	NNP
cord-318495-1w74wf02	317	7	/	/	SYM
cord-318495-1w74wf02	317	8	Chicken	Chicken	NNP
cord-318495-1w74wf02	317	9	/	/	SYM
cord-318495-1w74wf02	317	10	Pennsylvania/83	pennsylvania/83	CD
cord-318495-1w74wf02	317	11	influenza	influenza	NN
cord-318495-1w74wf02	317	12	virus	virus	NN
cord-318495-1w74wf02	317	13	Defective	defective	JJ
cord-318495-1w74wf02	317	14	interfering	interfere	VBG
cord-318495-1w74wf02	317	15	influenza	influenza	NN
cord-318495-1w74wf02	317	16	virus	virus	NN
cord-318495-1w74wf02	317	17	inhibits	inhibit	VBZ
cord-318495-1w74wf02	317	18	immunopathological	immunopathological	JJ
cord-318495-1w74wf02	317	19	effects	effect	NNS
cord-318495-1w74wf02	317	20	of	of	IN
cord-318495-1w74wf02	317	21	infectious	infectious	JJ
cord-318495-1w74wf02	317	22	virus	virus	NN
cord-318495-1w74wf02	317	23	in	in	IN
cord-318495-1w74wf02	317	24	the	the	DT
cord-318495-1w74wf02	317	25	mouse	mouse	NN
cord-318495-1w74wf02	317	26	Defective	defective	JJ
cord-318495-1w74wf02	317	27	interfering	interfere	VBG
cord-318495-1w74wf02	317	28	influenza	influenza	NN
cord-318495-1w74wf02	317	29	virus	virus	NN
cord-318495-1w74wf02	317	30	confers	confer	VBZ
cord-318495-1w74wf02	317	31	only	only	RB
cord-318495-1w74wf02	317	32	short	short	RB
cord-318495-1w74wf02	317	33	-	-	HYPH
cord-318495-1w74wf02	317	34	lived	live	VBN
cord-318495-1w74wf02	317	35	protection	protection	NN
cord-318495-1w74wf02	317	36	against	against	IN
cord-318495-1w74wf02	317	37	influenza	influenza	NNP
cord-318495-1w74wf02	317	38	virus	virus	NN
cord-318495-1w74wf02	317	39	disease	disease	NN
cord-318495-1w74wf02	317	40	:	:	:
cord-318495-1w74wf02	317	41	evidence	evidence	NN
cord-318495-1w74wf02	317	42	for	for	IN
cord-318495-1w74wf02	317	43	a	a	DT
cord-318495-1w74wf02	317	44	role	role	NN
cord-318495-1w74wf02	317	45	for	for	IN
cord-318495-1w74wf02	317	46	adaptive	adaptive	JJ
cord-318495-1w74wf02	317	47	immunity	immunity	NN
cord-318495-1w74wf02	317	48	in	in	IN
cord-318495-1w74wf02	317	49	DI	DI	NNP
cord-318495-1w74wf02	317	50	virus	virus	NN
cord-318495-1w74wf02	317	51	-	-	HYPH
cord-318495-1w74wf02	317	52	mediated	mediate	VBN
cord-318495-1w74wf02	317	53	protection	protection	NN
cord-318495-1w74wf02	317	54	in	in	IN
cord-318495-1w74wf02	317	55	vivo	vivo	NN
cord-318495-1w74wf02	317	56	Defective	defective	JJ
cord-318495-1w74wf02	317	57	interfering	interfere	VBG
cord-318495-1w74wf02	317	58	particles	particle	NNS
cord-318495-1w74wf02	317	59	of	of	IN
cord-318495-1w74wf02	317	60	human	human	JJ
cord-318495-1w74wf02	317	61	parainfluenza	parainfluenza	NNP
cord-318495-1w74wf02	317	62	virus	virus	NN
cord-318495-1w74wf02	317	63	3	3	CD
cord-318495-1w74wf02	317	64	Defective	defective	JJ
cord-318495-1w74wf02	317	65	measles	measle	NNS
cord-318495-1w74wf02	317	66	virus	virus	NN
cord-318495-1w74wf02	317	67	in	in	IN
cord-318495-1w74wf02	317	68	human	human	JJ
cord-318495-1w74wf02	317	69	subacute	subacute	JJ
cord-318495-1w74wf02	317	70	sclerosing	sclerosing	NN
cord-318495-1w74wf02	317	71	panencephalitis	panencephalitis	NNP
cord-318495-1w74wf02	317	72	brain	brain	NN
cord-318495-1w74wf02	317	73	Generation	Generation	NNP
cord-318495-1w74wf02	317	74	of	of	IN
cord-318495-1w74wf02	317	75	defective	defective	JJ
cord-318495-1w74wf02	317	76	interfering	interfere	VBG
cord-318495-1w74wf02	317	77	particles	particle	NNS
cord-318495-1w74wf02	317	78	by	by	IN
cord-318495-1w74wf02	317	79	two	two	CD
cord-318495-1w74wf02	317	80	vaccine	vaccine	NN
cord-318495-1w74wf02	317	81	strains	strain	NNS
cord-318495-1w74wf02	317	82	of	of	IN
cord-318495-1w74wf02	317	83	measles	measle	NNS
cord-318495-1w74wf02	317	84	virus	virus	NN
cord-318495-1w74wf02	317	85	Mumps	Mumps	NNP
cord-318495-1w74wf02	317	86	virus	virus	NN
cord-318495-1w74wf02	317	87	-	-	:
cord-318495-1w74wf02	317	88	persistently	persistently	RB
cord-318495-1w74wf02	317	89	infected	infect	VBN
cord-318495-1w74wf02	317	90	cell	cell	NN
cord-318495-1w74wf02	317	91	cultures	culture	NNS
cord-318495-1w74wf02	317	92	release	release	VBP
cord-318495-1w74wf02	317	93	defective	defective	JJ
cord-318495-1w74wf02	317	94	interfering	interfere	VBG
cord-318495-1w74wf02	317	95	virus	virus	NN
cord-318495-1w74wf02	317	96	particles	particle	NNS
cord-318495-1w74wf02	317	97	Identification	identification	NN
cord-318495-1w74wf02	317	98	of	of	IN
cord-318495-1w74wf02	317	99	transcriptive	transcriptive	JJ
cord-318495-1w74wf02	317	100	and	and	CC
cord-318495-1w74wf02	317	101	replicative	replicative	JJ
cord-318495-1w74wf02	317	102	intermediates	intermediate	NNS
cord-318495-1w74wf02	317	103	in	in	IN
cord-318495-1w74wf02	317	104	Sendai	Sendai	NNP
cord-318495-1w74wf02	317	105	virus	virus	NN
cord-318495-1w74wf02	317	106	-	-	HYPH
cord-318495-1w74wf02	317	107	infected	infect	VBN
cord-318495-1w74wf02	317	108	cells	cell	NNS
cord-318495-1w74wf02	318	1	Molecular	molecular	JJ
cord-318495-1w74wf02	318	2	cloning	cloning	NN
cord-318495-1w74wf02	318	3	of	of	IN
cord-318495-1w74wf02	318	4	natural	natural	JJ
cord-318495-1w74wf02	318	5	paramyxovirus	paramyxovirus	JJ
cord-318495-1w74wf02	318	6	copy	copy	NN
cord-318495-1w74wf02	318	7	-	-	HYPH
cord-318495-1w74wf02	318	8	back	back	NN
cord-318495-1w74wf02	318	9	defective	defective	JJ
cord-318495-1w74wf02	318	10	interfering	interfere	VBG
cord-318495-1w74wf02	318	11	RNAs	rna	NNS
cord-318495-1w74wf02	318	12	and	and	CC
cord-318495-1w74wf02	318	13	their	-PRON-	PRP$
cord-318495-1w74wf02	318	14	expression	expression	NN
cord-318495-1w74wf02	318	15	from	from	IN
cord-318495-1w74wf02	318	16	DNA	DNA	NNP
cord-318495-1w74wf02	318	17	Characterization	characterization	NN
cord-318495-1w74wf02	318	18	of	of	IN
cord-318495-1w74wf02	318	19	Bunyamwera	Bunyamwera	NNP
cord-318495-1w74wf02	318	20	virus	virus	NN
cord-318495-1w74wf02	318	21	defective	defective	JJ
cord-318495-1w74wf02	318	22	interfering	interfere	VBG
cord-318495-1w74wf02	318	23	particles	particle	NNS
cord-318495-1w74wf02	318	24	Characterization	characterization	NN
cord-318495-1w74wf02	318	25	of	of	IN
cord-318495-1w74wf02	318	26	Toscana	Toscana	NNP
cord-318495-1w74wf02	318	27	virus	virus	NN
cord-318495-1w74wf02	318	28	-	-	HYPH
cord-318495-1w74wf02	318	29	defective	defective	JJ
cord-318495-1w74wf02	318	30	interfering	interfere	VBG
cord-318495-1w74wf02	318	31	particles	particle	NNS
cord-318495-1w74wf02	318	32	generated	generate	VBN
cord-318495-1w74wf02	318	33	in	in	IN
cord-318495-1w74wf02	318	34	vivo	vivo	NNP
cord-318495-1w74wf02	318	35	Characteristics	characteristic	NNS
cord-318495-1w74wf02	318	36	of	of	IN
cord-318495-1w74wf02	318	37	a	a	DT
cord-318495-1w74wf02	318	38	respiratory	respiratory	JJ
cord-318495-1w74wf02	318	39	syncytial	syncytial	JJ
cord-318495-1w74wf02	318	40	virus	virus	NN
cord-318495-1w74wf02	318	41	persistently	persistently	RB
cord-318495-1w74wf02	318	42	infected	infect	VBD
cord-318495-1w74wf02	318	43	macrophage	macrophage	NN
cord-318495-1w74wf02	318	44	-	-	HYPH
cord-318495-1w74wf02	318	45	like	like	JJ
cord-318495-1w74wf02	318	46	culture	culture	NN
cord-318495-1w74wf02	318	47	A	a	DT
cord-318495-1w74wf02	318	48	transmissible	transmissible	JJ
cord-318495-1w74wf02	318	49	interfering	interfere	VBG
cord-318495-1w74wf02	318	50	component	component	NN
cord-318495-1w74wf02	318	51	of	of	IN
cord-318495-1w74wf02	319	1	vesicular	vesicular	JJ
cord-318495-1w74wf02	319	2	stomatitis	stomatitis	NN
cord-318495-1w74wf02	319	3	virus	virus	NN
cord-318495-1w74wf02	319	4	preparations	preparation	NNS
cord-318495-1w74wf02	320	1	Cyclic	cyclic	JJ
cord-318495-1w74wf02	320	2	production	production	NN
cord-318495-1w74wf02	320	3	of	of	IN
cord-318495-1w74wf02	320	4	vesicular	vesicular	JJ
cord-318495-1w74wf02	320	5	stomatitis	stomatitis	NN
cord-318495-1w74wf02	320	6	virus	virus	NN
cord-318495-1w74wf02	320	7	caused	cause	VBN
cord-318495-1w74wf02	320	8	by	by	IN
cord-318495-1w74wf02	320	9	defective	defective	JJ
cord-318495-1w74wf02	320	10	interfering	interfere	VBG
cord-318495-1w74wf02	320	11	particles	particle	NNS
cord-318495-1w74wf02	320	12	The	the	DT
cord-318495-1w74wf02	320	13	complete	complete	JJ
cord-318495-1w74wf02	320	14	sequence	sequence	NN
cord-318495-1w74wf02	320	15	of	of	IN
cord-318495-1w74wf02	320	16	a	a	DT
cord-318495-1w74wf02	320	17	unique	unique	JJ
cord-318495-1w74wf02	320	18	RNA	RNA	NNP
cord-318495-1w74wf02	320	19	species	specie	NNS
cord-318495-1w74wf02	320	20	synthesized	synthesize	VBN
cord-318495-1w74wf02	320	21	by	by	IN
cord-318495-1w74wf02	320	22	a	a	DT
cord-318495-1w74wf02	320	23	DI	DI	NNP
cord-318495-1w74wf02	320	24	particle	particle	NN
cord-318495-1w74wf02	320	25	of	of	IN
cord-318495-1w74wf02	320	26	VSV	VSV	NNP
cord-318495-1w74wf02	320	27	Interference	Interference	NNP
cord-318495-1w74wf02	320	28	among	among	IN
cord-318495-1w74wf02	320	29	defective	defective	JJ
cord-318495-1w74wf02	320	30	interfering	interfere	VBG
cord-318495-1w74wf02	320	31	particles	particle	NNS
cord-318495-1w74wf02	320	32	of	of	IN
cord-318495-1w74wf02	320	33	vesicular	vesicular	JJ
cord-318495-1w74wf02	320	34	stomatitis	stomatitis	NN
cord-318495-1w74wf02	320	35	virus	virus	NN
cord-318495-1w74wf02	320	36	Very	very	RB
cord-318495-1w74wf02	320	37	rapid	rapid	JJ
cord-318495-1w74wf02	320	38	generation	generation	NN
cord-318495-1w74wf02	320	39	/	/	SYM
cord-318495-1w74wf02	320	40	amplification	amplification	NN
cord-318495-1w74wf02	320	41	of	of	IN
cord-318495-1w74wf02	320	42	defective	defective	JJ
cord-318495-1w74wf02	320	43	interfering	interfere	VBG
cord-318495-1w74wf02	320	44	particles	particle	NNS
cord-318495-1w74wf02	320	45	by	by	IN
cord-318495-1w74wf02	320	46	vesicular	vesicular	JJ
cord-318495-1w74wf02	320	47	stomatitis	stomatitis	NN
cord-318495-1w74wf02	320	48	virus	virus	NN
cord-318495-1w74wf02	320	49	variants	variant	NNS
cord-318495-1w74wf02	320	50	isolated	isolate	VBN
cord-318495-1w74wf02	320	51	from	from	IN
cord-318495-1w74wf02	320	52	persistent	persistent	JJ
cord-318495-1w74wf02	320	53	infection	infection	NN
cord-318495-1w74wf02	321	1	Interferon	interferon	NN
cord-318495-1w74wf02	321	2	induction	induction	NN
cord-318495-1w74wf02	321	3	by	by	IN
cord-318495-1w74wf02	321	4	viruses	virus	NNS
cord-318495-1w74wf02	321	5	.	.	.
cord-318495-1w74wf02	322	1	XIX	XIX	NNP
cord-318495-1w74wf02	322	2	.	.	.
cord-318495-1w74wf02	323	1	Vesicular	vesicular	JJ
cord-318495-1w74wf02	323	2	stomatitis	stomatitis	NN
cord-318495-1w74wf02	323	3	virus	virus	NN
cord-318495-1w74wf02	323	4	-	-	:
cord-318495-1w74wf02	323	5	New	New	NNP
cord-318495-1w74wf02	323	6	Jersey	Jersey	NNP
cord-318495-1w74wf02	323	7	:	:	:
cord-318495-1w74wf02	324	1	high	high	JJ
cord-318495-1w74wf02	324	2	multiplicity	multiplicity	NN
cord-318495-1w74wf02	324	3	passages	passage	NNS
cord-318495-1w74wf02	324	4	generate	generate	VBP
cord-318495-1w74wf02	324	5	interferon	interferon	NN
cord-318495-1w74wf02	324	6	-	-	HYPH
cord-318495-1w74wf02	324	7	inducing	induce	VBG
cord-318495-1w74wf02	324	8	,	,	,
cord-318495-1w74wf02	324	9	defective	defective	JJ
cord-318495-1w74wf02	324	10	-	-	HYPH
cord-318495-1w74wf02	324	11	interfering	interfere	VBG
cord-318495-1w74wf02	324	12	particles	particle	NNS
cord-318495-1w74wf02	324	13	Generation	generation	NN
cord-318495-1w74wf02	324	14	of	of	IN
cord-318495-1w74wf02	324	15	envelope	envelope	NN
cord-318495-1w74wf02	324	16	and	and	CC
cord-318495-1w74wf02	324	17	defective	defective	JJ
cord-318495-1w74wf02	324	18	interfering	interfere	VBG
cord-318495-1w74wf02	324	19	RNA	RNA	NNP
cord-318495-1w74wf02	324	20	mutants	mutant	NNS
cord-318495-1w74wf02	324	21	of	of	IN
cord-318495-1w74wf02	324	22	tomato	tomato	NN
cord-318495-1w74wf02	324	23	spotted	spot	VBN
cord-318495-1w74wf02	324	24	wilt	wilt	NN
cord-318495-1w74wf02	324	25	virus	virus	NN
cord-318495-1w74wf02	324	26	by	by	IN
cord-318495-1w74wf02	324	27	mechanical	mechanical	JJ
cord-318495-1w74wf02	324	28	passage	passage	NN
cord-318495-1w74wf02	325	1	A	a	DT
cord-318495-1w74wf02	325	2	novel	novel	NN
cord-318495-1w74wf02	325	3	betapartitivirus	betapartitivirus	NN
cord-318495-1w74wf02	325	4	RnPV6	RnPV6	NNP
cord-318495-1w74wf02	325	5	from	from	IN
cord-318495-1w74wf02	325	6	Rosellinia	Rosellinia	NNP
cord-318495-1w74wf02	325	7	necatrix	necatrix	NNP
cord-318495-1w74wf02	325	8	tolerates	tolerate	VBZ
cord-318495-1w74wf02	325	9	host	host	NN
cord-318495-1w74wf02	325	10	RNA	RNA	NNP
cord-318495-1w74wf02	325	11	silencing	silencing	NN
cord-318495-1w74wf02	325	12	but	but	CC
cord-318495-1w74wf02	325	13	is	be	VBZ
cord-318495-1w74wf02	325	14	interfered	interfere	VBN
cord-318495-1w74wf02	325	15	by	by	IN
cord-318495-1w74wf02	325	16	its	-PRON-	PRP$
cord-318495-1w74wf02	325	17	defective	defective	JJ
cord-318495-1w74wf02	325	18	RNAs	rna	NNS
cord-318495-1w74wf02	325	19	Defective	defective	JJ
cord-318495-1w74wf02	325	20	virions	virion	NNS
cord-318495-1w74wf02	325	21	of	of	IN
cord-318495-1w74wf02	325	22	reovirus	reovirus	NNP
cord-318495-1w74wf02	325	23	Segment	segment	NN
cord-318495-1w74wf02	325	24	-	-	HYPH
cord-318495-1w74wf02	325	25	specific	specific	JJ
cord-318495-1w74wf02	325	26	inverted	inverted	JJ
cord-318495-1w74wf02	325	27	repeats	repeat	NNS
cord-318495-1w74wf02	325	28	found	find	VBN
cord-318495-1w74wf02	325	29	adjacent	adjacent	JJ
cord-318495-1w74wf02	325	30	to	to	IN
cord-318495-1w74wf02	325	31	conserved	conserve	VBN
cord-318495-1w74wf02	325	32	terminal	terminal	JJ
cord-318495-1w74wf02	325	33	sequences	sequence	NNS
cord-318495-1w74wf02	325	34	in	in	IN
cord-318495-1w74wf02	325	35	wound	wound	NN
cord-318495-1w74wf02	325	36	tumor	tumor	NN
cord-318495-1w74wf02	325	37	virus	virus	NN
cord-318495-1w74wf02	325	38	genome	genome	NN
cord-318495-1w74wf02	325	39	and	and	CC
cord-318495-1w74wf02	325	40	defective	defective	JJ
cord-318495-1w74wf02	325	41	interfering	interfere	VBG
cord-318495-1w74wf02	325	42	RNAs	rna	NNS
cord-318495-1w74wf02	325	43	Defective	defective	JJ
cord-318495-1w74wf02	325	44	proviruses	provirus	NNS
cord-318495-1w74wf02	325	45	rapidly	rapidly	RB
cord-318495-1w74wf02	325	46	accumulate	accumulate	VBP
cord-318495-1w74wf02	325	47	during	during	IN
cord-318495-1w74wf02	325	48	acute	acute	JJ
cord-318495-1w74wf02	325	49	HIV-1	HIV-1	NNP
cord-318495-1w74wf02	325	50	infection	infection	NN
cord-318495-1w74wf02	325	51	Accumulation	Accumulation	NNP
cord-318495-1w74wf02	325	52	of	of	IN
cord-318495-1w74wf02	325	53	defective	defective	JJ
cord-318495-1w74wf02	325	54	viral	viral	JJ
cord-318495-1w74wf02	325	55	genomes	genome	NNS
cord-318495-1w74wf02	325	56	in	in	IN
cord-318495-1w74wf02	325	57	peripheral	peripheral	JJ
cord-318495-1w74wf02	325	58	blood	blood	NN
cord-318495-1w74wf02	325	59	mononuclear	mononuclear	NN
cord-318495-1w74wf02	325	60	cells	cell	NNS
cord-318495-1w74wf02	325	61	of	of	IN
cord-318495-1w74wf02	325	62	human	human	JJ
cord-318495-1w74wf02	325	63	immunodeficiency	immunodeficiency	NN
cord-318495-1w74wf02	325	64	virus	virus	NN
cord-318495-1w74wf02	325	65	type	type	NN
cord-318495-1w74wf02	325	66	1-infected	1-infected	CD
cord-318495-1w74wf02	325	67	individuals	individual	NNS
cord-318495-1w74wf02	325	68	Satellite	Satellite	NNP
cord-318495-1w74wf02	325	69	RNAs	rna	NNS
cord-318495-1w74wf02	325	70	and	and	CC
cord-318495-1w74wf02	325	71	satellite	satellite	NN
cord-318495-1w74wf02	325	72	viruses	virus	NNS
cord-318495-1w74wf02	325	73	Plant	Plant	NNP
cord-318495-1w74wf02	325	74	virus	virus	NN
cord-318495-1w74wf02	325	75	satellite	satellite	NN
cord-318495-1w74wf02	325	76	and	and	CC
cord-318495-1w74wf02	325	77	defective	defective	JJ
cord-318495-1w74wf02	325	78	interfering	interfere	VBG
cord-318495-1w74wf02	325	79	RNAs	rna	NNS
cord-318495-1w74wf02	325	80	:	:	:
cord-318495-1w74wf02	325	81	new	new	JJ
cord-318495-1w74wf02	325	82	paradigms	paradigm	NNS
cord-318495-1w74wf02	325	83	for	for	IN
cord-318495-1w74wf02	325	84	a	a	DT
cord-318495-1w74wf02	325	85	new	new	JJ
cord-318495-1w74wf02	325	86	century	century	NN
cord-318495-1w74wf02	325	87	Properties	property	NNS
cord-318495-1w74wf02	325	88	of	of	IN
cord-318495-1w74wf02	325	89	satellite	satellite	NN
cord-318495-1w74wf02	325	90	tobacco	tobacco	NN
cord-318495-1w74wf02	325	91	mosaic	mosaic	NNP
cord-318495-1w74wf02	325	92	virus	virus	NN
cord-318495-1w74wf02	325	93	phenotypes	phenotype	NNS
cord-318495-1w74wf02	325	94	expressed	express	VBN
cord-318495-1w74wf02	325	95	in	in	IN
cord-318495-1w74wf02	325	96	the	the	DT
cord-318495-1w74wf02	325	97	presence	presence	NN
cord-318495-1w74wf02	325	98	and	and	CC
cord-318495-1w74wf02	325	99	absence	absence	NN
cord-318495-1w74wf02	325	100	of	of	IN
cord-318495-1w74wf02	325	101	helper	helper	NN
cord-318495-1w74wf02	325	102	virus	virus	NN
cord-318495-1w74wf02	325	103	A	a	DT
cord-318495-1w74wf02	325	104	classification	classification	NN
cord-318495-1w74wf02	325	105	system	system	NN
cord-318495-1w74wf02	325	106	for	for	IN
cord-318495-1w74wf02	325	107	virophages	virophage	NNS
cord-318495-1w74wf02	325	108	and	and	CC
cord-318495-1w74wf02	325	109	satellite	satellite	NN
cord-318495-1w74wf02	325	110	viruses	virus	NNS
cord-318495-1w74wf02	326	1	Virus	virus	NN
cord-318495-1w74wf02	326	2	-	-	HYPH
cord-318495-1w74wf02	326	3	associated	associate	VBN
cord-318495-1w74wf02	326	4	small	small	JJ
cord-318495-1w74wf02	326	5	satellite	satellite	NN
cord-318495-1w74wf02	326	6	RNAs	rna	NNS
cord-318495-1w74wf02	326	7	and	and	CC
cord-318495-1w74wf02	326	8	viroids	viroid	NNS
cord-318495-1w74wf02	326	9	display	display	VBP
cord-318495-1w74wf02	326	10	similarities	similarity	NNS
cord-318495-1w74wf02	326	11	in	in	IN
cord-318495-1w74wf02	326	12	their	-PRON-	PRP$
cord-318495-1w74wf02	326	13	replication	replication	NN
cord-318495-1w74wf02	326	14	strategies	strategy	NNS
cord-318495-1w74wf02	326	15	What	what	WP
cord-318495-1w74wf02	326	16	has	have	VBZ
cord-318495-1w74wf02	326	17	been	be	VBN
cord-318495-1w74wf02	326	18	happening	happen	VBG
cord-318495-1w74wf02	326	19	with	with	IN
cord-318495-1w74wf02	326	20	viroids	viroid	NNS
cord-318495-1w74wf02	326	21	?	?	.
cord-318495-1w74wf02	327	1	The	the	DT
cord-318495-1w74wf02	327	2	expanding	expand	VBG
cord-318495-1w74wf02	327	3	family	family	NN
cord-318495-1w74wf02	327	4	of	of	IN
cord-318495-1w74wf02	327	5	virophages	virophages	NNP
cord-318495-1w74wf02	328	1	The	the	DT
cord-318495-1w74wf02	328	2	virophage	virophage	NN
cord-318495-1w74wf02	328	3	as	as	IN
cord-318495-1w74wf02	328	4	a	a	DT
cord-318495-1w74wf02	328	5	unique	unique	JJ
cord-318495-1w74wf02	328	6	parasite	parasite	NN
cord-318495-1w74wf02	328	7	of	of	IN
cord-318495-1w74wf02	328	8	the	the	DT
cord-318495-1w74wf02	328	9	giant	giant	JJ
cord-318495-1w74wf02	328	10	mimivirus	mimivirus	NNP
cord-318495-1w74wf02	328	11	Ecogenomics	Ecogenomics	NNP
cord-318495-1w74wf02	328	12	of	of	IN
cord-318495-1w74wf02	328	13	virophages	virophage	NNS
cord-318495-1w74wf02	328	14	and	and	CC
cord-318495-1w74wf02	328	15	their	-PRON-	PRP$
cord-318495-1w74wf02	328	16	giant	giant	JJ
cord-318495-1w74wf02	328	17	virus	virus	NN
cord-318495-1w74wf02	328	18	hosts	host	NNS
cord-318495-1w74wf02	328	19	assessed	assess	VBN
cord-318495-1w74wf02	328	20	through	through	IN
cord-318495-1w74wf02	328	21	time	time	NN
cord-318495-1w74wf02	328	22	series	series	NN
cord-318495-1w74wf02	328	23	metagenomics	metagenomic	NNS
cord-318495-1w74wf02	328	24	Capsid	Capsid	NNP
cord-318495-1w74wf02	328	25	protein	protein	NN
cord-318495-1w74wf02	328	26	structure	structure	NN
cord-318495-1w74wf02	328	27	,	,	,
cord-318495-1w74wf02	328	28	self	self	NN
cord-318495-1w74wf02	328	29	-	-	HYPH
cord-318495-1w74wf02	328	30	assembly	assembly	NN
cord-318495-1w74wf02	328	31	,	,	,
cord-318495-1w74wf02	328	32	and	and	CC
cord-318495-1w74wf02	328	33	processing	process	VBG
cord-318495-1w74wf02	328	34	reveal	reveal	VBP
cord-318495-1w74wf02	328	35	morphogenesis	morphogenesis	NN
cord-318495-1w74wf02	328	36	of	of	IN
cord-318495-1w74wf02	328	37	the	the	DT
cord-318495-1w74wf02	328	38	marine	marine	JJ
cord-318495-1w74wf02	328	39	virophage	virophage	NNP
cord-318495-1w74wf02	328	40	mavirus	mavirus	NNP
cord-318495-1w74wf02	328	41	Virus	Virus	NNP
cord-318495-1w74wf02	328	42	-	-	HYPH
cord-318495-1w74wf02	328	43	Like	Like	NNP
cord-318495-1w74wf02	328	44	Vesicles	Vesicles	NNP
cord-318495-1w74wf02	328	45	of	of	IN
cord-318495-1w74wf02	328	46	Kaposi	Kaposi	NNP
cord-318495-1w74wf02	328	47	's	's	POS
cord-318495-1w74wf02	328	48	Sarcoma	Sarcoma	NNP
cord-318495-1w74wf02	328	49	-	-	HYPH
cord-318495-1w74wf02	328	50	Associated	Associated	NNP
cord-318495-1w74wf02	328	51	Herpesvirus	Herpesvirus	NNP
cord-318495-1w74wf02	328	52	Activate	activate	VBP
cord-318495-1w74wf02	328	53	Lytic	lytic	JJ
cord-318495-1w74wf02	328	54	Replication	replication	NN
cord-318495-1w74wf02	328	55	by	by	IN
cord-318495-1w74wf02	328	56	Triggering	trigger	VBG
cord-318495-1w74wf02	328	57	Differentiation	differentiation	NN
cord-318495-1w74wf02	328	58	Signaling	signal	VBG
cord-318495-1w74wf02	328	59	Ultrastructural	Ultrastructural	NNP
cord-318495-1w74wf02	328	60	and	and	CC
cord-318495-1w74wf02	328	61	biophysical	biophysical	JJ
cord-318495-1w74wf02	328	62	characterization	characterization	NN
cord-318495-1w74wf02	328	63	of	of	IN
cord-318495-1w74wf02	328	64	hepatitis	hepatitis	NN
cord-318495-1w74wf02	328	65	C	C	NNP
cord-318495-1w74wf02	328	66	virus	virus	NN
cord-318495-1w74wf02	328	67	particles	particle	NNS
cord-318495-1w74wf02	328	68	produced	produce	VBN
cord-318495-1w74wf02	328	69	in	in	IN
cord-318495-1w74wf02	328	70	cell	cell	NN
cord-318495-1w74wf02	328	71	culture	culture	NN
cord-318495-1w74wf02	329	1	Extracellular	Extracellular	NNP
cord-318495-1w74wf02	329	2	vesicles	vesicle	NNS
cord-318495-1w74wf02	329	3	released	release	VBN
cord-318495-1w74wf02	329	4	by	by	IN
cord-318495-1w74wf02	329	5	herpes	herpes	NNP
cord-318495-1w74wf02	329	6	simplex	simplex	NNP
cord-318495-1w74wf02	329	7	virus	virus	NN
cord-318495-1w74wf02	329	8	1	1	CD
cord-318495-1w74wf02	329	9	infected	infect	VBN
cord-318495-1w74wf02	329	10	cells	cell	NNS
cord-318495-1w74wf02	329	11	block	block	VBP
cord-318495-1w74wf02	329	12	virus	virus	NN
cord-318495-1w74wf02	329	13	replication	replication	NN
cord-318495-1w74wf02	329	14	in	in	IN
cord-318495-1w74wf02	329	15	recipient	recipient	NN
cord-318495-1w74wf02	329	16	cells	cell	NNS
cord-318495-1w74wf02	329	17	in	in	IN
cord-318495-1w74wf02	329	18	a	a	DT
cord-318495-1w74wf02	329	19	STING	sting	NN
cord-318495-1w74wf02	329	20	-	-	HYPH
cord-318495-1w74wf02	329	21	dependent	dependent	JJ
cord-318495-1w74wf02	329	22	manner	manner	NN
cord-318495-1w74wf02	330	1	This	this	DT
cord-318495-1w74wf02	330	2	work	work	NN
cord-318495-1w74wf02	330	3	was	be	VBD
cord-318495-1w74wf02	330	4	supported	support	VBN
cord-318495-1w74wf02	330	5	by	by	IN
cord-318495-1w74wf02	330	6	the	the	DT
cord-318495-1w74wf02	330	7	US	US	NNP
cord-318495-1w74wf02	330	8	National	National	NNP
cord-318495-1w74wf02	330	9	Institutes	Institutes	NNPS
cord-318495-1w74wf02	330	10	of	of	IN
cord-318495-1w74wf02	330	11	Health	Health	NNP
cord-318495-1w74wf02	330	12	National	National	NNP
cord-318495-1w74wf02	330	13	Institute	Institute	NNP
cord-318495-1w74wf02	330	14	of	of	IN
cord-318495-1w74wf02	330	15	Allergy	Allergy	NNP
cord-318495-1w74wf02	330	16	and	and	CC
cord-318495-1w74wf02	330	17	Infectious	Infectious	NNP
cord-318495-1w74wf02	330	18	Diseases	Diseases	NNPS
cord-318495-1w74wf02	330	19	(	(	-LRB-
cord-318495-1w74wf02	330	20	grants	grant	NNS
cord-318495-1w74wf02	330	21	nos	nos	NNP
cord-318495-1w74wf02	330	22	.	.	.
cord-318495-1w74wf02	331	1	NIH	NIH	NNP
cord-318495-1w74wf02	331	2	AI083284	AI083284	NNP
cord-318495-1w74wf02	331	3	,	,	,
cord-318495-1w74wf02	331	4	AI137062	AI137062	NNP
cord-318495-1w74wf02	331	5	and	and	CC
cord-318495-1w74wf02	331	6	AI134862	ai134862	NN
cord-318495-1w74wf02	331	7	to	to	IN
cord-318495-1w74wf02	331	8	C.B.L.	C.B.L.	NNP
cord-318495-1w74wf02	331	9	)	)	-RRB-
cord-318495-1w74wf02	331	10	and	and	CC
cord-318495-1w74wf02	331	11	the	the	DT
cord-318495-1w74wf02	331	12	DARPA	DARPA	NNP
cord-318495-1w74wf02	331	13	INTERCEPT	INTERCEPT	NNP
cord-318495-1w74wf02	331	14	program	program	NN
cord-318495-1w74wf02	331	15	(	(	-LRB-
cord-318495-1w74wf02	331	16	to	to	IN
cord-318495-1w74wf02	331	17	M.V.	M.V.	NNP
cord-318495-1w74wf02	331	18	)	)	-RRB-
cord-318495-1w74wf02	331	19	managed	manage	VBN
cord-318495-1w74wf02	331	20	by	by	IN
cord-318495-1w74wf02	331	21	J.	J.	NNP
cord-318495-1w74wf02	331	22	Gimlett	Gimlett	NNP
cord-318495-1w74wf02	331	23	and	and	CC
cord-318495-1w74wf02	331	24	administered	administer	VBN
cord-318495-1w74wf02	331	25	though	though	IN
cord-318495-1w74wf02	331	26	DARPA	DARPA	NNP
cord-318495-1w74wf02	331	27	Cooperative	Cooperative	NNP
cord-318495-1w74wf02	331	28	Agreement	Agreement	NNP
cord-318495-1w74wf02	331	29	(	(	-LRB-
cord-318495-1w74wf02	331	30	grant	grant	VB
cord-318495-1w74wf02	331	31	no	no	NN
cord-318495-1w74wf02	331	32	.	.	.
cord-318495-1w74wf02	332	1	HR0011	HR0011	NNP
cord-318495-1w74wf02	332	2	-	-	HYPH
cord-318495-1w74wf02	332	3	17	17	CD
cord-318495-1w74wf02	332	4	-	-	HYPH
cord-318495-1w74wf02	332	5	2	2	CD
cord-318495-1w74wf02	332	6	-	-	HYPH
cord-318495-1w74wf02	332	7	0023	0023	CD
cord-318495-1w74wf02	332	8	)	)	-RRB-
cord-318495-1w74wf02	332	9	.	.	.
cord-318495-1w74wf02	333	1	In	in	IN
cord-318495-1w74wf02	333	2	addition	addition	NN
cord-318495-1w74wf02	333	3	,	,	,
cord-318495-1w74wf02	333	4	this	this	DT
cord-318495-1w74wf02	333	5	work	work	NN
cord-318495-1w74wf02	333	6	was	be	VBD
cord-318495-1w74wf02	333	7	supported	support	VBN
cord-318495-1w74wf02	333	8	by	by	IN
cord-318495-1w74wf02	333	9	a	a	DT
cord-318495-1w74wf02	333	10	Fulbright	Fulbright	NNP
cord-318495-1w74wf02	333	11	US	US	NNP
cord-318495-1w74wf02	333	12	Scholar	Scholar	NNP
cord-318495-1w74wf02	333	13	award	award	NN
cord-318495-1w74wf02	333	14	to	to	IN
cord-318495-1w74wf02	333	15	C.B.L.	c.b.l.	NN
cord-318495-1w74wf02	334	1	The	the	DT
cord-318495-1w74wf02	334	2	views	view	NNS
cord-318495-1w74wf02	334	3	expressed	express	VBN
cord-318495-1w74wf02	334	4	in	in	IN
cord-318495-1w74wf02	334	5	this	this	DT
cord-318495-1w74wf02	334	6	article	article	NN
cord-318495-1w74wf02	334	7	do	do	VBP
cord-318495-1w74wf02	334	8	not	not	RB
cord-318495-1w74wf02	334	9	necessarily	necessarily	RB
cord-318495-1w74wf02	334	10	represent	represent	VB
cord-318495-1w74wf02	334	11	the	the	DT
cord-318495-1w74wf02	334	12	position	position	NN
cord-318495-1w74wf02	334	13	or	or	CC
cord-318495-1w74wf02	334	14	the	the	DT
cord-318495-1w74wf02	334	15	policy	policy	NN
cord-318495-1w74wf02	334	16	of	of	IN
cord-318495-1w74wf02	334	17	the	the	DT
cord-318495-1w74wf02	334	18	US	US	NNP
cord-318495-1w74wf02	334	19	government	government	NN
cord-318495-1w74wf02	335	1	The	the	DT
cord-318495-1w74wf02	335	2	authors	author	NNS
cord-318495-1w74wf02	335	3	declare	declare	VBP
cord-318495-1w74wf02	335	4	no	no	DT
cord-318495-1w74wf02	335	5	competing	compete	VBG
cord-318495-1w74wf02	335	6	interests	interest	NNS
cord-318495-1w74wf02	335	7	.	.	.
cord-318495-1w74wf02	336	1	Reprints	reprint	NNS
cord-318495-1w74wf02	336	2	and	and	CC
cord-318495-1w74wf02	336	3	permissions	permission	NNS
cord-318495-1w74wf02	336	4	information	information	NN
cord-318495-1w74wf02	336	5	is	be	VBZ
cord-318495-1w74wf02	336	6	available	available	JJ
cord-318495-1w74wf02	336	7	at	at	IN
cord-318495-1w74wf02	336	8	www.nature.com/reprints.Correspondence	www.nature.com/reprints.correspondence	NN
cord-318495-1w74wf02	336	9	should	should	MD
cord-318495-1w74wf02	336	10	be	be	VB
cord-318495-1w74wf02	336	11	addressed	address	VBN
cord-318495-1w74wf02	336	12	to	to	IN
cord-318495-1w74wf02	336	13	C.B.L.Publisher	C.B.L.Publisher	NNP
cord-318495-1w74wf02	336	14	's	's	POS
cord-318495-1w74wf02	336	15	note	note	NN
cord-318495-1w74wf02	336	16	:	:	:
cord-318495-1w74wf02	336	17	Springer	Springer	NNP
cord-318495-1w74wf02	336	18	Nature	Nature	NNP
cord-318495-1w74wf02	336	19	remains	remain	VBZ
cord-318495-1w74wf02	336	20	neutral	neutral	JJ
cord-318495-1w74wf02	336	21	with	with	IN
cord-318495-1w74wf02	336	22	regard	regard	NN
cord-318495-1w74wf02	336	23	to	to	IN
cord-318495-1w74wf02	336	24	jurisdictional	jurisdictional	JJ
cord-318495-1w74wf02	336	25	claims	claim	NNS
cord-318495-1w74wf02	336	26	in	in	IN
cord-318495-1w74wf02	336	27	published	publish	VBN
cord-318495-1w74wf02	336	28	maps	map	NNS
cord-318495-1w74wf02	336	29	and	and	CC
cord-318495-1w74wf02	336	30	institutional	institutional	JJ
cord-318495-1w74wf02	336	31	affiliations	affiliation	NNS
cord-318495-1w74wf02	336	32	.	.	.