id sid tid token lemma pos cord-348409-oxjd263z 1 1 key key NNP cord-348409-oxjd263z 1 2 : : : cord-348409-oxjd263z 1 3 cord-348409-oxjd263z cord-348409-oxjd263z JJ cord-348409-oxjd263z 2 1 authors author NNS cord-348409-oxjd263z 2 2 : : : cord-348409-oxjd263z 2 3 Stern Stern NNP cord-348409-oxjd263z 2 4 , , , cord-348409-oxjd263z 2 5 Zachariah Zachariah NNP cord-348409-oxjd263z 2 6 ; ; : cord-348409-oxjd263z 2 7 Stylianou Stylianou NNP cord-348409-oxjd263z 2 8 , , , cord-348409-oxjd263z 2 9 Dora Dora NNP cord-348409-oxjd263z 2 10 C. C. NNP cord-348409-oxjd263z 2 11 ; ; : cord-348409-oxjd263z 2 12 Kostrikis Kostrikis NNP cord-348409-oxjd263z 2 13 , , , cord-348409-oxjd263z 2 14 Leondios Leondios NNP cord-348409-oxjd263z 2 15 G. G. NNP cord-348409-oxjd263z 2 16 title title NN cord-348409-oxjd263z 2 17 : : : cord-348409-oxjd263z 3 1 The the DT cord-348409-oxjd263z 3 2 development development NN cord-348409-oxjd263z 3 3 of of IN cord-348409-oxjd263z 3 4 inovirus inovirus NNP cord-348409-oxjd263z 3 5 - - HYPH cord-348409-oxjd263z 3 6 associated associate VBN cord-348409-oxjd263z 3 7 vector vector NN cord-348409-oxjd263z 3 8 vaccines vaccine NNS cord-348409-oxjd263z 3 9 using use VBG cord-348409-oxjd263z 3 10 phage phage NN cord-348409-oxjd263z 3 11 - - HYPH cord-348409-oxjd263z 3 12 display display NN cord-348409-oxjd263z 3 13 technologies technology NNS cord-348409-oxjd263z 3 14 date date NN cord-348409-oxjd263z 3 15 : : : cord-348409-oxjd263z 3 16 2019 2019 CD cord-348409-oxjd263z 3 17 - - HYPH cord-348409-oxjd263z 3 18 09 09 CD cord-348409-oxjd263z 3 19 - - HYPH cord-348409-oxjd263z 3 20 08 08 CD cord-348409-oxjd263z 3 21 journal journal NN cord-348409-oxjd263z 3 22 : : : cord-348409-oxjd263z 4 1 Expert Expert NNP cord-348409-oxjd263z 4 2 Rev Rev NNP cord-348409-oxjd263z 4 3 Vaccines Vaccines NNP cord-348409-oxjd263z 4 4 DOI DOI NNP cord-348409-oxjd263z 4 5 : : : cord-348409-oxjd263z 4 6 10.1080/14760584.2019.1651649 10.1080/14760584.2019.1651649 NNP cord-348409-oxjd263z 4 7 sha sha NNP cord-348409-oxjd263z 4 8 : : : cord-348409-oxjd263z 4 9 5d13cd0bf64f462281d34e7fcf845b5ddc541c83 5d13cd0bf64f462281d34e7fcf845b5ddc541c83 CD cord-348409-oxjd263z 4 10 doc_id doc_id CD cord-348409-oxjd263z 4 11 : : : cord-348409-oxjd263z 4 12 348409 348409 CD cord-348409-oxjd263z 4 13 cord_uid cord_uid NNS cord-348409-oxjd263z 4 14 : : : cord-348409-oxjd263z 5 1 oxjd263z oxjd263z NNP cord-348409-oxjd263z 6 1 Introduction introduction NN cord-348409-oxjd263z 6 2 : : : cord-348409-oxjd263z 6 3 Inovirus Inovirus NNP cord-348409-oxjd263z 6 4 - - HYPH cord-348409-oxjd263z 6 5 associated associate VBN cord-348409-oxjd263z 6 6 vectors vector NNS cord-348409-oxjd263z 6 7 ( ( -LRB- cord-348409-oxjd263z 6 8 IAVs iav NNS cord-348409-oxjd263z 6 9 ) ) -RRB- cord-348409-oxjd263z 6 10 are be VBP cord-348409-oxjd263z 6 11 derived derive VBN cord-348409-oxjd263z 6 12 from from IN cord-348409-oxjd263z 6 13 bacterial bacterial JJ cord-348409-oxjd263z 6 14 filamentous filamentous JJ cord-348409-oxjd263z 6 15 viruses virus NNS cord-348409-oxjd263z 6 16 ( ( -LRB- cord-348409-oxjd263z 6 17 phages phage NNS cord-348409-oxjd263z 6 18 ) ) -RRB- cord-348409-oxjd263z 6 19 . . . cord-348409-oxjd263z 7 1 As as IN cord-348409-oxjd263z 7 2 vaccine vaccine NN cord-348409-oxjd263z 7 3 carriers carrier NNS cord-348409-oxjd263z 7 4 , , , cord-348409-oxjd263z 7 5 they -PRON- PRP cord-348409-oxjd263z 7 6 have have VBP cord-348409-oxjd263z 7 7 elicited elicit VBN cord-348409-oxjd263z 7 8 both both DT cord-348409-oxjd263z 7 9 cellular cellular JJ cord-348409-oxjd263z 7 10 and and CC cord-348409-oxjd263z 7 11 humoral humoral JJ cord-348409-oxjd263z 7 12 responses response NNS cord-348409-oxjd263z 7 13 against against IN cord-348409-oxjd263z 7 14 a a DT cord-348409-oxjd263z 7 15 variety variety NN cord-348409-oxjd263z 7 16 of of IN cord-348409-oxjd263z 7 17 pathogens pathogen NNS cord-348409-oxjd263z 7 18 causing cause VBG cord-348409-oxjd263z 7 19 infectious infectious JJ cord-348409-oxjd263z 7 20 diseases disease NNS cord-348409-oxjd263z 7 21 and and CC cord-348409-oxjd263z 7 22 other other JJ cord-348409-oxjd263z 7 23 non non JJ cord-348409-oxjd263z 7 24 - - JJ cord-348409-oxjd263z 7 25 infectious infectious JJ cord-348409-oxjd263z 7 26 diseases disease NNS cord-348409-oxjd263z 7 27 . . . cord-348409-oxjd263z 8 1 By by IN cord-348409-oxjd263z 8 2 displaying display VBG cord-348409-oxjd263z 8 3 specific specific JJ cord-348409-oxjd263z 8 4 antigen antigen NN cord-348409-oxjd263z 8 5 epitopes epitope NNS cord-348409-oxjd263z 8 6 or or CC cord-348409-oxjd263z 8 7 proteins protein NNS cord-348409-oxjd263z 8 8 on on IN cord-348409-oxjd263z 8 9 their -PRON- PRP$ cord-348409-oxjd263z 8 10 coat coat NN cord-348409-oxjd263z 8 11 proteins protein NNS cord-348409-oxjd263z 8 12 , , , cord-348409-oxjd263z 8 13 IAVs iav NNS cord-348409-oxjd263z 8 14 have have VBP cord-348409-oxjd263z 8 15 merited merit VBN cord-348409-oxjd263z 8 16 much much JJ cord-348409-oxjd263z 8 17 study study NN cord-348409-oxjd263z 8 18 , , , cord-348409-oxjd263z 8 19 as as IN cord-348409-oxjd263z 8 20 their -PRON- PRP$ cord-348409-oxjd263z 8 21 unique unique JJ cord-348409-oxjd263z 8 22 abilities ability NNS cord-348409-oxjd263z 8 23 are be VBP cord-348409-oxjd263z 8 24 exploited exploit VBN cord-348409-oxjd263z 8 25 for for IN cord-348409-oxjd263z 8 26 widespread widespread JJ cord-348409-oxjd263z 8 27 vaccine vaccine NN cord-348409-oxjd263z 8 28 development development NN cord-348409-oxjd263z 8 29 . . . cord-348409-oxjd263z 9 1 Areas area NNS cord-348409-oxjd263z 9 2 covered cover VBN cord-348409-oxjd263z 9 3 : : : cord-348409-oxjd263z 10 1 The the DT cord-348409-oxjd263z 10 2 architectural architectural JJ cord-348409-oxjd263z 10 3 traits trait NNS cord-348409-oxjd263z 10 4 of of IN cord-348409-oxjd263z 10 5 filamentous filamentous JJ cord-348409-oxjd263z 10 6 viruses virus NNS cord-348409-oxjd263z 10 7 and and CC cord-348409-oxjd263z 10 8 their -PRON- PRP$ cord-348409-oxjd263z 10 9 derivatives derivative NNS cord-348409-oxjd263z 10 10 , , , cord-348409-oxjd263z 10 11 IAVs iav NNS cord-348409-oxjd263z 10 12 , , , cord-348409-oxjd263z 10 13 facilitate facilitate VBP cord-348409-oxjd263z 10 14 the the DT cord-348409-oxjd263z 10 15 display display NN cord-348409-oxjd263z 10 16 of of IN cord-348409-oxjd263z 10 17 specific specific JJ cord-348409-oxjd263z 10 18 antigenic antigenic JJ cord-348409-oxjd263z 10 19 peptides peptide NNS cord-348409-oxjd263z 10 20 which which WDT cord-348409-oxjd263z 10 21 induce induce VBP cord-348409-oxjd263z 10 22 antibody antibody NN cord-348409-oxjd263z 10 23 production production NN cord-348409-oxjd263z 10 24 to to TO cord-348409-oxjd263z 10 25 prevent prevent VB cord-348409-oxjd263z 10 26 or or CC cord-348409-oxjd263z 10 27 curtail curtail VB cord-348409-oxjd263z 10 28 infection infection NN cord-348409-oxjd263z 10 29 . . . cord-348409-oxjd263z 11 1 Inoviruses Inoviruses NNP cord-348409-oxjd263z 11 2 provide provide VBP cord-348409-oxjd263z 11 3 a a DT cord-348409-oxjd263z 11 4 foundation foundation NN cord-348409-oxjd263z 11 5 for for IN cord-348409-oxjd263z 11 6 cost cost NN cord-348409-oxjd263z 11 7 - - HYPH cord-348409-oxjd263z 11 8 efficient efficient JJ cord-348409-oxjd263z 11 9 large large JJ cord-348409-oxjd263z 11 10 - - HYPH cord-348409-oxjd263z 11 11 scale scale NN cord-348409-oxjd263z 11 12 specific specific JJ cord-348409-oxjd263z 11 13 phage phage NN cord-348409-oxjd263z 11 14 display display NN cord-348409-oxjd263z 11 15 . . . cord-348409-oxjd263z 12 1 In in IN cord-348409-oxjd263z 12 2 this this DT cord-348409-oxjd263z 12 3 paper paper NN cord-348409-oxjd263z 12 4 , , , cord-348409-oxjd263z 12 5 the the DT cord-348409-oxjd263z 12 6 development development NN cord-348409-oxjd263z 12 7 of of IN cord-348409-oxjd263z 12 8 different different JJ cord-348409-oxjd263z 12 9 applications application NNS cord-348409-oxjd263z 12 10 of of IN cord-348409-oxjd263z 12 11 inovirus inovirus NNP cord-348409-oxjd263z 12 12 - - HYPH cord-348409-oxjd263z 12 13 based base VBN cord-348409-oxjd263z 12 14 phage phage NN cord-348409-oxjd263z 12 15 display display NN cord-348409-oxjd263z 12 16 vaccines vaccine NNS cord-348409-oxjd263z 12 17 across across IN cord-348409-oxjd263z 12 18 a a DT cord-348409-oxjd263z 12 19 broad broad JJ cord-348409-oxjd263z 12 20 range range NN cord-348409-oxjd263z 12 21 of of IN cord-348409-oxjd263z 12 22 pathogens pathogen NNS cord-348409-oxjd263z 12 23 and and CC cord-348409-oxjd263z 12 24 hosts host NNS cord-348409-oxjd263z 12 25 is be VBZ cord-348409-oxjd263z 12 26 reviewed review VBN cord-348409-oxjd263z 12 27 . . . cord-348409-oxjd263z 13 1 The the DT cord-348409-oxjd263z 13 2 references reference NNS cord-348409-oxjd263z 13 3 cited cite VBN cord-348409-oxjd263z 13 4 in in IN cord-348409-oxjd263z 13 5 this this DT cord-348409-oxjd263z 13 6 review review NN cord-348409-oxjd263z 13 7 were be VBD cord-348409-oxjd263z 13 8 selected select VBN cord-348409-oxjd263z 13 9 from from IN cord-348409-oxjd263z 13 10 established establish VBN cord-348409-oxjd263z 13 11 databases database NNS cord-348409-oxjd263z 13 12 based base VBN cord-348409-oxjd263z 13 13 on on IN cord-348409-oxjd263z 13 14 the the DT cord-348409-oxjd263z 13 15 authors author NNS cord-348409-oxjd263z 13 16 ’ ’ POS cord-348409-oxjd263z 13 17 knowledge knowledge NN cord-348409-oxjd263z 13 18 of of IN cord-348409-oxjd263z 13 19 the the DT cord-348409-oxjd263z 13 20 study study NN cord-348409-oxjd263z 13 21 subject subject NN cord-348409-oxjd263z 13 22 . . . cord-348409-oxjd263z 14 1 Expert expert NN cord-348409-oxjd263z 14 2 commentary commentary NN cord-348409-oxjd263z 14 3 : : : cord-348409-oxjd263z 15 1 The the DT cord-348409-oxjd263z 15 2 importance importance NN cord-348409-oxjd263z 15 3 of of IN cord-348409-oxjd263z 15 4 phage phage NN cord-348409-oxjd263z 15 5 - - HYPH cord-348409-oxjd263z 15 6 display display NN cord-348409-oxjd263z 15 7 technology technology NN cord-348409-oxjd263z 15 8 has have VBZ cord-348409-oxjd263z 15 9 been be VBN cord-348409-oxjd263z 15 10 recently recently RB cord-348409-oxjd263z 15 11 highlighted highlight VBN cord-348409-oxjd263z 15 12 by by IN cord-348409-oxjd263z 15 13 the the DT cord-348409-oxjd263z 15 14 Nobel Nobel NNP cord-348409-oxjd263z 15 15 Prize Prize NNP cord-348409-oxjd263z 15 16 in in IN cord-348409-oxjd263z 15 17 Chemistry Chemistry NNP cord-348409-oxjd263z 15 18 2018 2018 CD cord-348409-oxjd263z 15 19 awarded award VBN cord-348409-oxjd263z 15 20 to to IN cord-348409-oxjd263z 15 21 George George NNP cord-348409-oxjd263z 15 22 P. P. NNP cord-348409-oxjd263z 15 23 Smith Smith NNP cord-348409-oxjd263z 15 24 and and CC cord-348409-oxjd263z 15 25 Sir Sir NNP cord-348409-oxjd263z 15 26 Gregory Gregory NNP cord-348409-oxjd263z 15 27 P. P. NNP cord-348409-oxjd263z 15 28 Winter Winter NNP cord-348409-oxjd263z 15 29 . . . cord-348409-oxjd263z 16 1 Furthermore furthermore RB cord-348409-oxjd263z 16 2 , , , cord-348409-oxjd263z 16 3 the the DT cord-348409-oxjd263z 16 4 symbiotic symbiotic JJ cord-348409-oxjd263z 16 5 nature nature NN cord-348409-oxjd263z 16 6 of of IN cord-348409-oxjd263z 16 7 filamentous filamentous JJ cord-348409-oxjd263z 16 8 viruses virus NNS cord-348409-oxjd263z 16 9 infecting infect VBG cord-348409-oxjd263z 16 10 intestinal intestinal JJ cord-348409-oxjd263z 16 11 F(+ F(+ NNS cord-348409-oxjd263z 16 12 ) ) -RRB- cord-348409-oxjd263z 17 1 E. E. NNP cord-348409-oxjd263z 17 2 coli coli VBZ cord-348409-oxjd263z 17 3 strains strain NNS cord-348409-oxjd263z 17 4 offers offer VBZ cord-348409-oxjd263z 17 5 an an DT cord-348409-oxjd263z 17 6 attractive attractive JJ cord-348409-oxjd263z 17 7 platform platform NN cord-348409-oxjd263z 17 8 for for IN cord-348409-oxjd263z 17 9 the the DT cord-348409-oxjd263z 17 10 development development NN cord-348409-oxjd263z 17 11 of of IN cord-348409-oxjd263z 17 12 novel novel JJ cord-348409-oxjd263z 17 13 vaccines vaccine NNS cord-348409-oxjd263z 17 14 that that WDT cord-348409-oxjd263z 17 15 stimulate stimulate VBP cord-348409-oxjd263z 17 16 mucosal mucosal JJ cord-348409-oxjd263z 17 17 immunity immunity NN cord-348409-oxjd263z 17 18 Research Research NNP cord-348409-oxjd263z 17 19 regarding regard VBG cord-348409-oxjd263z 17 20 the the DT cord-348409-oxjd263z 17 21 potential potential NN cord-348409-oxjd263z 17 22 to to TO cord-348409-oxjd263z 17 23 use use VB cord-348409-oxjd263z 17 24 viruses virus NNS cord-348409-oxjd263z 17 25 to to IN cord-348409-oxjd263z 17 26 combat combat NN cord-348409-oxjd263z 17 27 disease disease NN cord-348409-oxjd263z 17 28 has have VBZ cord-348409-oxjd263z 17 29 been be VBN cord-348409-oxjd263z 17 30 ongoing ongoing JJ cord-348409-oxjd263z 17 31 for for IN cord-348409-oxjd263z 17 32 over over IN cord-348409-oxjd263z 17 33 100 100 CD cord-348409-oxjd263z 17 34 years year NNS cord-348409-oxjd263z 17 35 [ [ -LRB- cord-348409-oxjd263z 17 36 1 1 CD cord-348409-oxjd263z 17 37 , , , cord-348409-oxjd263z 17 38 2 2 CD cord-348409-oxjd263z 17 39 ] ] -RRB- cord-348409-oxjd263z 17 40 . . . cord-348409-oxjd263z 18 1 While while IN cord-348409-oxjd263z 18 2 viruses virus NNS cord-348409-oxjd263z 18 3 have have VBP cord-348409-oxjd263z 18 4 often often RB cord-348409-oxjd263z 18 5 been be VBN cord-348409-oxjd263z 18 6 considered consider VBN cord-348409-oxjd263z 18 7 pernicious pernicious JJ cord-348409-oxjd263z 18 8 as as IN cord-348409-oxjd263z 18 9 they -PRON- PRP cord-348409-oxjd263z 18 10 co co VBD cord-348409-oxjd263z 18 11 - - VB cord-348409-oxjd263z 18 12 opt opt VB cord-348409-oxjd263z 18 13 a a DT cord-348409-oxjd263z 18 14 host host NN cord-348409-oxjd263z 18 15 for for IN cord-348409-oxjd263z 18 16 their -PRON- PRP$ cord-348409-oxjd263z 18 17 own own JJ cord-348409-oxjd263z 18 18 survival survival NN cord-348409-oxjd263z 18 19 , , , cord-348409-oxjd263z 18 20 often often RB cord-348409-oxjd263z 18 21 killing kill VBG cord-348409-oxjd263z 18 22 the the DT cord-348409-oxjd263z 18 23 host host NN cord-348409-oxjd263z 18 24 in in IN cord-348409-oxjd263z 18 25 the the DT cord-348409-oxjd263z 18 26 process process NN cord-348409-oxjd263z 18 27 , , , cord-348409-oxjd263z 18 28 new new JJ cord-348409-oxjd263z 18 29 work work NN cord-348409-oxjd263z 18 30 with with IN cord-348409-oxjd263z 18 31 viruses virus NNS cord-348409-oxjd263z 18 32 that that WDT cord-348409-oxjd263z 18 33 can can MD cord-348409-oxjd263z 18 34 be be VB cord-348409-oxjd263z 18 35 exploited exploit VBN cord-348409-oxjd263z 18 36 as as IN cord-348409-oxjd263z 18 37 bacteriophages bacteriophage NNS cord-348409-oxjd263z 18 38 but but CC cord-348409-oxjd263z 18 39 without without IN cord-348409-oxjd263z 18 40 the the DT cord-348409-oxjd263z 18 41 harmful harmful JJ cord-348409-oxjd263z 18 42 effects effect NNS cord-348409-oxjd263z 18 43 has have VBZ cord-348409-oxjd263z 18 44 arisen arise VBN cord-348409-oxjd263z 18 45 [ [ -LRB- cord-348409-oxjd263z 18 46 3 3 CD cord-348409-oxjd263z 18 47 ] ] -RRB- cord-348409-oxjd263z 18 48 . . . cord-348409-oxjd263z 19 1 These these DT cord-348409-oxjd263z 19 2 viruses virus NNS cord-348409-oxjd263z 19 3 , , , cord-348409-oxjd263z 19 4 which which WDT cord-348409-oxjd263z 19 5 can can MD cord-348409-oxjd263z 19 6 be be VB cord-348409-oxjd263z 19 7 easily easily RB cord-348409-oxjd263z 19 8 manipulated manipulate VBN cord-348409-oxjd263z 19 9 and and CC cord-348409-oxjd263z 19 10 employed employ VBN cord-348409-oxjd263z 19 11 for for IN cord-348409-oxjd263z 19 12 phage phage NN cord-348409-oxjd263z 19 13 display display NN cord-348409-oxjd263z 19 14 ability ability NN cord-348409-oxjd263z 19 15 , , , cord-348409-oxjd263z 19 16 are be VBP cord-348409-oxjd263z 19 17 being be VBG cord-348409-oxjd263z 19 18 increasingly increasingly RB cord-348409-oxjd263z 19 19 used use VBN cord-348409-oxjd263z 19 20 for for IN cord-348409-oxjd263z 19 21 a a DT cord-348409-oxjd263z 19 22 variety variety NN cord-348409-oxjd263z 19 23 of of IN cord-348409-oxjd263z 19 24 potent potent JJ cord-348409-oxjd263z 19 25 biomedical biomedical JJ cord-348409-oxjd263z 19 26 tools tool NNS cord-348409-oxjd263z 19 27 [ [ -LRB- cord-348409-oxjd263z 19 28 4 4 CD cord-348409-oxjd263z 19 29 ] ] -RRB- cord-348409-oxjd263z 19 30 . . . cord-348409-oxjd263z 20 1 These these DT cord-348409-oxjd263z 20 2 filamentous filamentous JJ cord-348409-oxjd263z 20 3 bacterial bacterial JJ cord-348409-oxjd263z 20 4 viruses virus NNS cord-348409-oxjd263z 20 5 , , , cord-348409-oxjd263z 20 6 which which WDT cord-348409-oxjd263z 20 7 make make VBP cord-348409-oxjd263z 20 8 up up RP cord-348409-oxjd263z 20 9 the the DT cord-348409-oxjd263z 20 10 genus genus NN cord-348409-oxjd263z 20 11 Inovirus Inovirus NNP cord-348409-oxjd263z 20 12 in in IN cord-348409-oxjd263z 20 13 the the DT cord-348409-oxjd263z 20 14 family family NN cord-348409-oxjd263z 20 15 Inoviridae Inoviridae NNP cord-348409-oxjd263z 20 16 , , , cord-348409-oxjd263z 20 17 are be VBP cord-348409-oxjd263z 20 18 thread thread NN cord-348409-oxjd263z 20 19 - - HYPH cord-348409-oxjd263z 20 20 like like JJ cord-348409-oxjd263z 20 21 viruses virus NNS cord-348409-oxjd263z 20 22 containing contain VBG cord-348409-oxjd263z 20 23 single single RB cord-348409-oxjd263z 20 24 - - HYPH cord-348409-oxjd263z 20 25 stranded strand VBN cord-348409-oxjd263z 20 26 DNA dna NN cord-348409-oxjd263z 20 27 genomes genome NNS cord-348409-oxjd263z 20 28 know know VBP cord-348409-oxjd263z 20 29 as as IN cord-348409-oxjd263z 20 30 filamentous filamentous JJ cord-348409-oxjd263z 20 31 bacteriophages bacteriophage NNS cord-348409-oxjd263z 20 32 [ [ -LRB- cord-348409-oxjd263z 20 33 5 5 CD cord-348409-oxjd263z 20 34 ] ] -RRB- cord-348409-oxjd263z 20 35 [ [ -LRB- cord-348409-oxjd263z 20 36 6 6 CD cord-348409-oxjd263z 20 37 ] ] -RRB- cord-348409-oxjd263z 20 38 [ [ -LRB- cord-348409-oxjd263z 20 39 7 7 CD cord-348409-oxjd263z 20 40 ] ] -RRB- cord-348409-oxjd263z 20 41 . . . cord-348409-oxjd263z 21 1 Over over IN cord-348409-oxjd263z 21 2 50 50 CD cord-348409-oxjd263z 21 3 different different JJ cord-348409-oxjd263z 21 4 species specie NNS cord-348409-oxjd263z 21 5 of of IN cord-348409-oxjd263z 21 6 filamentous filamentous JJ cord-348409-oxjd263z 21 7 viruses virus NNS cord-348409-oxjd263z 21 8 are be VBP cord-348409-oxjd263z 21 9 known know VBN cord-348409-oxjd263z 21 10 , , , cord-348409-oxjd263z 21 11 of of IN cord-348409-oxjd263z 21 12 which which WDT cord-348409-oxjd263z 21 13 a a DT cord-348409-oxjd263z 21 14 majority majority NN cord-348409-oxjd263z 21 15 can can MD cord-348409-oxjd263z 21 16 infect infect VB cord-348409-oxjd263z 21 17 Gram gram NN cord-348409-oxjd263z 21 18 - - HYPH cord-348409-oxjd263z 21 19 negative negative JJ cord-348409-oxjd263z 21 20 bacteria bacteria NNS cord-348409-oxjd263z 21 21 . . . cord-348409-oxjd263z 22 1 Although although IN cord-348409-oxjd263z 22 2 inoviruses inoviruse NNS cord-348409-oxjd263z 22 3 are be VBP cord-348409-oxjd263z 22 4 now now RB cord-348409-oxjd263z 22 5 being be VBG cord-348409-oxjd263z 22 6 used use VBN cord-348409-oxjd263z 22 7 for for IN cord-348409-oxjd263z 22 8 their -PRON- PRP$ cord-348409-oxjd263z 22 9 phage phage NN cord-348409-oxjd263z 22 10 display display NN cord-348409-oxjd263z 22 11 capabilities capability NNS cord-348409-oxjd263z 22 12 , , , cord-348409-oxjd263z 22 13 these these DT cord-348409-oxjd263z 22 14 filamentous filamentous JJ cord-348409-oxjd263z 22 15 viruses virus NNS cord-348409-oxjd263z 22 16 have have VBP cord-348409-oxjd263z 22 17 a a DT cord-348409-oxjd263z 22 18 relationship relationship NN cord-348409-oxjd263z 22 19 with with IN cord-348409-oxjd263z 22 20 the the DT cord-348409-oxjd263z 22 21 cell cell NN cord-348409-oxjd263z 22 22 that that WDT cord-348409-oxjd263z 22 23 they -PRON- PRP cord-348409-oxjd263z 22 24 infect infect VBP cord-348409-oxjd263z 22 25 that that DT cord-348409-oxjd263z 22 26 is be VBZ cord-348409-oxjd263z 22 27 more more RBR cord-348409-oxjd263z 22 28 similar similar JJ cord-348409-oxjd263z 22 29 to to IN cord-348409-oxjd263z 22 30 symbiotic symbiotic JJ cord-348409-oxjd263z 22 31 non non JJ cord-348409-oxjd263z 22 32 - - JJ cord-348409-oxjd263z 22 33 pathogenic pathogenic JJ cord-348409-oxjd263z 22 34 animal animal NN cord-348409-oxjd263z 22 35 viruses virus NNS cord-348409-oxjd263z 22 36 than than IN cord-348409-oxjd263z 22 37 classical classical JJ cord-348409-oxjd263z 22 38 phages phage NNS cord-348409-oxjd263z 22 39 . . . cord-348409-oxjd263z 23 1 Unlike unlike IN cord-348409-oxjd263z 23 2 phages phage NNS cord-348409-oxjd263z 23 3 , , , cord-348409-oxjd263z 23 4 which which WDT cord-348409-oxjd263z 23 5 term term NN cord-348409-oxjd263z 23 6 comes come VBZ cord-348409-oxjd263z 23 7 from from IN cord-348409-oxjd263z 23 8 the the DT cord-348409-oxjd263z 23 9 Greek greek JJ cord-348409-oxjd263z 23 10 word word NN cord-348409-oxjd263z 23 11 φάγος φάγος NN cord-348409-oxjd263z 23 12 for for IN cord-348409-oxjd263z 23 13 destroyer destroyer NN cord-348409-oxjd263z 23 14 , , , cord-348409-oxjd263z 23 15 inoviruses inoviruse NNS cord-348409-oxjd263z 23 16 do do VBP cord-348409-oxjd263z 23 17 not not RB cord-348409-oxjd263z 23 18 kill kill VB cord-348409-oxjd263z 23 19 their -PRON- PRP$ cord-348409-oxjd263z 23 20 host host NN cord-348409-oxjd263z 23 21 and and CC cord-348409-oxjd263z 23 22 only only RB cord-348409-oxjd263z 23 23 slightly slightly RB cord-348409-oxjd263z 23 24 affect affect VBP cord-348409-oxjd263z 23 25 cell cell NN cord-348409-oxjd263z 23 26 growth growth NN cord-348409-oxjd263z 23 27 despite despite IN cord-348409-oxjd263z 23 28 yielding yield VBG cord-348409-oxjd263z 23 29 titers titer NNS cord-348409-oxjd263z 23 30 of of IN cord-348409-oxjd263z 23 31 up up IN cord-348409-oxjd263z 23 32 to to TO cord-348409-oxjd263z 23 33 10 10 CD cord-348409-oxjd263z 23 34 13 13 CD cord-348409-oxjd263z 23 35 virions virion NNS cord-348409-oxjd263z 23 36 per per IN cord-348409-oxjd263z 23 37 milliliter milliliter NN cord-348409-oxjd263z 23 38 of of IN cord-348409-oxjd263z 23 39 liquid liquid JJ cord-348409-oxjd263z 23 40 culture culture NN cord-348409-oxjd263z 23 41 . . . cord-348409-oxjd263z 24 1 Progeny progeny JJ cord-348409-oxjd263z 24 2 virions virion NNS cord-348409-oxjd263z 24 3 are be VBP cord-348409-oxjd263z 24 4 assembled assemble VBN cord-348409-oxjd263z 24 5 in in IN cord-348409-oxjd263z 24 6 the the DT cord-348409-oxjd263z 24 7 host host NN cord-348409-oxjd263z 24 8 cell cell NN cord-348409-oxjd263z 24 9 's 's POS cord-348409-oxjd263z 24 10 membrane membrane NN cord-348409-oxjd263z 24 11 where where WRB cord-348409-oxjd263z 24 12 single single RB cord-348409-oxjd263z 24 13 - - HYPH cord-348409-oxjd263z 24 14 stranded strand VBN cord-348409-oxjd263z 24 15 DNA dna NN cord-348409-oxjd263z 24 16 binding binding NN cord-348409-oxjd263z 24 17 proteins protein NNS cord-348409-oxjd263z 24 18 are be VBP cord-348409-oxjd263z 24 19 replaced replace VBN cord-348409-oxjd263z 24 20 by by IN cord-348409-oxjd263z 24 21 major major JJ cord-348409-oxjd263z 24 22 capsid capsid NN cord-348409-oxjd263z 24 23 protein protein NN cord-348409-oxjd263z 24 24 subunits subunit NNS cord-348409-oxjd263z 24 25 before before IN cord-348409-oxjd263z 24 26 being be VBG cord-348409-oxjd263z 24 27 released release VBN cord-348409-oxjd263z 24 28 into into IN cord-348409-oxjd263z 24 29 the the DT cord-348409-oxjd263z 24 30 cell cell NN cord-348409-oxjd263z 24 31 , , , cord-348409-oxjd263z 24 32 resulting result VBG cord-348409-oxjd263z 24 33 in in IN cord-348409-oxjd263z 24 34 opaque opaque JJ cord-348409-oxjd263z 24 35 plaques plaque NNS cord-348409-oxjd263z 24 36 on on IN cord-348409-oxjd263z 24 37 bacterial bacterial JJ cord-348409-oxjd263z 24 38 lawns lawn NNS cord-348409-oxjd263z 24 39 [ [ -LRB- cord-348409-oxjd263z 24 40 8 8 CD cord-348409-oxjd263z 24 41 , , , cord-348409-oxjd263z 24 42 9 9 CD cord-348409-oxjd263z 24 43 ] ] -RRB- cord-348409-oxjd263z 24 44 . . . cord-348409-oxjd263z 25 1 Receptor receptor NN cord-348409-oxjd263z 25 2 organelles organelle NNS cord-348409-oxjd263z 25 3 in in IN cord-348409-oxjd263z 25 4 the the DT cord-348409-oxjd263z 25 5 bacterial bacterial JJ cord-348409-oxjd263z 25 6 host host NN cord-348409-oxjd263z 25 7 that that WDT cord-348409-oxjd263z 25 8 are be VBP cord-348409-oxjd263z 25 9 encoded encode VBN cord-348409-oxjd263z 25 10 by by IN cord-348409-oxjd263z 25 11 transmissible transmissible JJ cord-348409-oxjd263z 25 12 plasmids plasmid NNS cord-348409-oxjd263z 25 13 facilitate facilitate VBP cord-348409-oxjd263z 25 14 the the DT cord-348409-oxjd263z 25 15 interactions interaction NNS cord-348409-oxjd263z 25 16 between between IN cord-348409-oxjd263z 25 17 inovirus inovirus NNP cord-348409-oxjd263z 25 18 and and CC cord-348409-oxjd263z 25 19 cell cell NN cord-348409-oxjd263z 25 20 [ [ -LRB- cord-348409-oxjd263z 25 21 5 5 CD cord-348409-oxjd263z 25 22 , , , cord-348409-oxjd263z 25 23 10 10 CD cord-348409-oxjd263z 25 24 ] ] -RRB- cord-348409-oxjd263z 25 25 . . . cord-348409-oxjd263z 26 1 The the DT cord-348409-oxjd263z 26 2 functional functional JJ cord-348409-oxjd263z 26 3 architecture architecture NN cord-348409-oxjd263z 26 4 of of IN cord-348409-oxjd263z 26 5 inoviruses inoviruses NNP cord-348409-oxjd263z 26 6 provides provide VBZ cord-348409-oxjd263z 26 7 the the DT cord-348409-oxjd263z 26 8 foundation foundation NN cord-348409-oxjd263z 26 9 for for IN cord-348409-oxjd263z 26 10 their -PRON- PRP$ cord-348409-oxjd263z 26 11 application application NN cord-348409-oxjd263z 26 12 in in IN cord-348409-oxjd263z 26 13 vaccine vaccine NN cord-348409-oxjd263z 26 14 - - HYPH cord-348409-oxjd263z 26 15 related relate VBN cord-348409-oxjd263z 26 16 projects project NNS cord-348409-oxjd263z 26 17 since since IN cord-348409-oxjd263z 26 18 inoviruses inoviruse NNS cord-348409-oxjd263z 26 19 do do VBP cord-348409-oxjd263z 26 20 not not RB cord-348409-oxjd263z 26 21 cause cause VB cord-348409-oxjd263z 26 22 harm harm NN cord-348409-oxjd263z 26 23 . . . cord-348409-oxjd263z 27 1 A a DT cord-348409-oxjd263z 27 2 great great JJ cord-348409-oxjd263z 27 3 number number NN cord-348409-oxjd263z 27 4 of of IN cord-348409-oxjd263z 27 5 inovirus inovirus NNP cord-348409-oxjd263z 27 6 species specie NNS cord-348409-oxjd263z 27 7 across across IN cord-348409-oxjd263z 27 8 the the DT cord-348409-oxjd263z 27 9 world world NN cord-348409-oxjd263z 27 10 have have VBP cord-348409-oxjd263z 27 11 been be VBN cord-348409-oxjd263z 27 12 isolated isolate VBN cord-348409-oxjd263z 27 13 and and CC cord-348409-oxjd263z 27 14 characterized characterize VBN cord-348409-oxjd263z 27 15 [ [ -LRB- cord-348409-oxjd263z 27 16 5 5 CD cord-348409-oxjd263z 27 17 ] ] -RRB- cord-348409-oxjd263z 27 18 . . . cord-348409-oxjd263z 28 1 Despite despite IN cord-348409-oxjd263z 28 2 variation variation NN cord-348409-oxjd263z 28 3 by by IN cord-348409-oxjd263z 28 4 species specie NNS cord-348409-oxjd263z 28 5 , , , cord-348409-oxjd263z 28 6 they -PRON- PRP cord-348409-oxjd263z 28 7 have have VBP cord-348409-oxjd263z 28 8 the the DT cord-348409-oxjd263z 28 9 same same JJ cord-348409-oxjd263z 28 10 general general JJ cord-348409-oxjd263z 28 11 physical physical JJ cord-348409-oxjd263z 28 12 characteristics characteristic NNS cord-348409-oxjd263z 28 13 . . . cord-348409-oxjd263z 29 1 The the DT cord-348409-oxjd263z 29 2 virions virion NNS cord-348409-oxjd263z 29 3 are be VBP cord-348409-oxjd263z 29 4 flexible flexible JJ cord-348409-oxjd263z 29 5 , , , cord-348409-oxjd263z 29 6 thin thin JJ cord-348409-oxjd263z 29 7 cylindrical cylindrical JJ cord-348409-oxjd263z 29 8 filaments filament NNS cord-348409-oxjd263z 29 9 [ [ -LRB- cord-348409-oxjd263z 29 10 6 6 CD cord-348409-oxjd263z 29 11 , , , cord-348409-oxjd263z 29 12 7 7 CD cord-348409-oxjd263z 29 13 ] ] -RRB- cord-348409-oxjd263z 29 14 under under IN cord-348409-oxjd263z 29 15 10 10 CD cord-348409-oxjd263z 29 16 nm nm NN cord-348409-oxjd263z 29 17 in in IN cord-348409-oxjd263z 29 18 diameter diameter NN cord-348409-oxjd263z 29 19 and and CC cord-348409-oxjd263z 29 20 approximately approximately RB cord-348409-oxjd263z 29 21 1000 1000 CD cord-348409-oxjd263z 29 22 nm nm NN cord-348409-oxjd263z 29 23 in in IN cord-348409-oxjd263z 29 24 length length NN cord-348409-oxjd263z 29 25 ( ( -LRB- cord-348409-oxjd263z 29 26 see see VB cord-348409-oxjd263z 29 27 Figure Figure NNP cord-348409-oxjd263z 29 28 _SP cord-348409-oxjd263z 29 29 1 1 CD cord-348409-oxjd263z 29 30 ( ( -LRB- cord-348409-oxjd263z 29 31 a a LS cord-348409-oxjd263z 29 32 ) ) -RRB- cord-348409-oxjd263z 29 33 for for IN cord-348409-oxjd263z 29 34 details detail NNS cord-348409-oxjd263z 29 35 ) ) -RRB- cord-348409-oxjd263z 29 36 . . . cord-348409-oxjd263z 30 1 Most Most JJS cord-348409-oxjd263z 30 2 of of IN cord-348409-oxjd263z 30 3 a a DT cord-348409-oxjd263z 30 4 single single JJ cord-348409-oxjd263z 30 5 virion virion NN cord-348409-oxjd263z 30 6 is be VBZ cord-348409-oxjd263z 30 7 composed compose VBN cord-348409-oxjd263z 30 8 of of IN cord-348409-oxjd263z 30 9 several several JJ cord-348409-oxjd263z 30 10 thousand thousand CD cord-348409-oxjd263z 30 11 major major JJ cord-348409-oxjd263z 30 12 capsid capsid NN cord-348409-oxjd263z 30 13 or or CC cord-348409-oxjd263z 30 14 coat coat NN cord-348409-oxjd263z 30 15 protein protein NN cord-348409-oxjd263z 30 16 subunits subunit NNS cord-348409-oxjd263z 30 17 . . . cord-348409-oxjd263z 31 1 These these DT cord-348409-oxjd263z 31 2 surround surround VBP cord-348409-oxjd263z 31 3 a a DT cord-348409-oxjd263z 31 4 circular circular JJ cord-348409-oxjd263z 31 5 single single RB cord-348409-oxjd263z 31 6 - - HYPH cord-348409-oxjd263z 31 7 stranded strand VBN cord-348409-oxjd263z 31 8 DNA dna NN cord-348409-oxjd263z 31 9 molecule molecule NN cord-348409-oxjd263z 31 10 . . . cord-348409-oxjd263z 32 1 At at IN cord-348409-oxjd263z 32 2 the the DT cord-348409-oxjd263z 32 3 proximal proximal JJ cord-348409-oxjd263z 32 4 end end NN cord-348409-oxjd263z 32 5 of of IN cord-348409-oxjd263z 32 6 the the DT cord-348409-oxjd263z 32 7 virion virion NN cord-348409-oxjd263z 32 8 there there EX cord-348409-oxjd263z 32 9 are be VBP cord-348409-oxjd263z 32 10 a a DT cord-348409-oxjd263z 32 11 few few JJ cord-348409-oxjd263z 32 12 minor minor JJ cord-348409-oxjd263z 32 13 proteins protein NNS cord-348409-oxjd263z 32 14 which which WDT cord-348409-oxjd263z 32 15 attach attach VBP cord-348409-oxjd263z 32 16 to to IN cord-348409-oxjd263z 32 17 the the DT cord-348409-oxjd263z 32 18 cell cell NN cord-348409-oxjd263z 32 19 to to TO cord-348409-oxjd263z 32 20 initiate initiate VB cord-348409-oxjd263z 32 21 infection infection NN cord-348409-oxjd263z 32 22 . . . cord-348409-oxjd263z 33 1 At at IN cord-348409-oxjd263z 33 2 the the DT cord-348409-oxjd263z 33 3 distal distal JJ cord-348409-oxjd263z 33 4 end end NN cord-348409-oxjd263z 33 5 , , , cord-348409-oxjd263z 33 6 there there EX cord-348409-oxjd263z 33 7 other other JJ cord-348409-oxjd263z 33 8 minor minor JJ cord-348409-oxjd263z 33 9 proteins protein NNS cord-348409-oxjd263z 33 10 which which WDT cord-348409-oxjd263z 33 11 are be VBP cord-348409-oxjd263z 33 12 used use VBN cord-348409-oxjd263z 33 13 for for IN cord-348409-oxjd263z 33 14 nucleation nucleation NN cord-348409-oxjd263z 33 15 and and CC cord-348409-oxjd263z 33 16 assembly assembly NN cord-348409-oxjd263z 33 17 on on IN cord-348409-oxjd263z 33 18 the the DT cord-348409-oxjd263z 33 19 host host NN cord-348409-oxjd263z 33 20 membrane membrane NN cord-348409-oxjd263z 33 21 . . . cord-348409-oxjd263z 34 1 The the DT cord-348409-oxjd263z 34 2 structures structure NNS cord-348409-oxjd263z 34 3 and and CC cord-348409-oxjd263z 34 4 life life NN cord-348409-oxjd263z 34 5 cycles cycle NNS cord-348409-oxjd263z 34 6 are be VBP cord-348409-oxjd263z 34 7 conserved conserve VBN cord-348409-oxjd263z 34 8 across across IN cord-348409-oxjd263z 34 9 different different JJ cord-348409-oxjd263z 34 10 species specie NNS cord-348409-oxjd263z 34 11 of of IN cord-348409-oxjd263z 34 12 inoviruses inoviruse NNS cord-348409-oxjd263z 34 13 , , , cord-348409-oxjd263z 34 14 resulting result VBG cord-348409-oxjd263z 34 15 in in IN cord-348409-oxjd263z 34 16 similar similar JJ cord-348409-oxjd263z 34 17 functional functional JJ cord-348409-oxjd263z 34 18 applications application NNS cord-348409-oxjd263z 34 19 . . . cord-348409-oxjd263z 35 1 Research research NN cord-348409-oxjd263z 35 2 into into IN cord-348409-oxjd263z 35 3 inovirus inovirus JJ cord-348409-oxjd263z 35 4 structure structure NN cord-348409-oxjd263z 35 5 and and CC cord-348409-oxjd263z 35 6 application application NN cord-348409-oxjd263z 35 7 has have VBZ cord-348409-oxjd263z 35 8 been be VBN cord-348409-oxjd263z 35 9 dominated dominate VBN cord-348409-oxjd263z 35 10 by by IN cord-348409-oxjd263z 35 11 studies study NNS cord-348409-oxjd263z 35 12 of of IN cord-348409-oxjd263z 35 13 Ff Ff NNP cord-348409-oxjd263z 35 14 [ [ -LRB- cord-348409-oxjd263z 35 15 11 11 CD cord-348409-oxjd263z 35 16 ] ] -RRB- cord-348409-oxjd263z 35 17 , , , cord-348409-oxjd263z 35 18 which which WDT cord-348409-oxjd263z 35 19 infect infect VBP cord-348409-oxjd263z 35 20 male male NN cord-348409-oxjd263z 35 21 ( ( -LRB- cord-348409-oxjd263z 35 22 F f NN cord-348409-oxjd263z 35 23 + + CC cord-348409-oxjd263z 35 24 ) ) -RRB- cord-348409-oxjd263z 35 25 strains strain NNS cord-348409-oxjd263z 35 26 of of IN cord-348409-oxjd263z 35 27 E. E. NNP cord-348409-oxjd263z 35 28 coli coli NNS cord-348409-oxjd263z 35 29 . . . cord-348409-oxjd263z 36 1 The the DT cord-348409-oxjd263z 36 2 most most RBS cord-348409-oxjd263z 36 3 used used JJ cord-348409-oxjd263z 36 4 and and CC cord-348409-oxjd263z 36 5 best best RB cord-348409-oxjd263z 36 6 understood understand VBN cord-348409-oxjd263z 36 7 of of IN cord-348409-oxjd263z 36 8 the the DT cord-348409-oxjd263z 36 9 Ff Ff NNP cord-348409-oxjd263z 36 10 inoviruses inoviruse NNS cord-348409-oxjd263z 36 11 are be VBP cord-348409-oxjd263z 36 12 the the DT cord-348409-oxjd263z 36 13 closely closely RB cord-348409-oxjd263z 36 14 related related JJ cord-348409-oxjd263z 36 15 fd fd NNP cord-348409-oxjd263z 36 16 , , , cord-348409-oxjd263z 36 17 f1 f1 NNP cord-348409-oxjd263z 36 18 , , , cord-348409-oxjd263z 36 19 and and CC cord-348409-oxjd263z 36 20 M13 M13 NNP cord-348409-oxjd263z 36 21 types type NNS cord-348409-oxjd263z 36 22 ( ( -LRB- cord-348409-oxjd263z 36 23 for for IN cord-348409-oxjd263z 36 24 reviews review NNS cord-348409-oxjd263z 36 25 see see VBP cord-348409-oxjd263z 36 26 [ [ -LRB- cord-348409-oxjd263z 36 27 9 9 CD cord-348409-oxjd263z 36 28 ] ] -RRB- cord-348409-oxjd263z 36 29 [ [ -LRB- cord-348409-oxjd263z 36 30 10 10 CD cord-348409-oxjd263z 36 31 ] ] -RRB- cord-348409-oxjd263z 36 32 [ [ -LRB- cord-348409-oxjd263z 36 33 11 11 CD cord-348409-oxjd263z 36 34 ] ] -RRB- cord-348409-oxjd263z 36 35 ) ) -RRB- cord-348409-oxjd263z 36 36 for for IN cord-348409-oxjd263z 36 37 which which WDT cord-348409-oxjd263z 36 38 extensive extensive JJ cord-348409-oxjd263z 36 39 information information NN cord-348409-oxjd263z 36 40 regarding regard VBG cord-348409-oxjd263z 36 41 their -PRON- PRP$ cord-348409-oxjd263z 36 42 life life NN cord-348409-oxjd263z 36 43 cycle cycle NN cord-348409-oxjd263z 36 44 and and CC cord-348409-oxjd263z 36 45 genetics genetics NN cord-348409-oxjd263z 36 46 is be VBZ cord-348409-oxjd263z 36 47 known know VBN cord-348409-oxjd263z 36 48 . . . cord-348409-oxjd263z 37 1 These these DT cord-348409-oxjd263z 37 2 nearly nearly RB cord-348409-oxjd263z 37 3 identical identical JJ cord-348409-oxjd263z 37 4 viruses virus NNS cord-348409-oxjd263z 37 5 almost almost RB cord-348409-oxjd263z 37 6 perfectly perfectly RB cord-348409-oxjd263z 37 7 share share VBP cord-348409-oxjd263z 37 8 all all DT cord-348409-oxjd263z 37 9 structural structural JJ cord-348409-oxjd263z 37 10 motifs motif NNS cord-348409-oxjd263z 37 11 , , , cord-348409-oxjd263z 37 12 including include VBG cord-348409-oxjd263z 37 13 DNA dna NN cord-348409-oxjd263z 37 14 and and CC cord-348409-oxjd263z 37 15 protein protein NN cord-348409-oxjd263z 37 16 sequences sequence NNS cord-348409-oxjd263z 37 17 and and CC cord-348409-oxjd263z 37 18 gene gene NN cord-348409-oxjd263z 37 19 organization organization NN cord-348409-oxjd263z 37 20 [ [ -LRB- cord-348409-oxjd263z 37 21 12 12 CD cord-348409-oxjd263z 37 22 ] ] -RRB- cord-348409-oxjd263z 37 23 [ [ -LRB- cord-348409-oxjd263z 37 24 13 13 CD cord-348409-oxjd263z 37 25 ] ] -RRB- cord-348409-oxjd263z 37 26 [ [ -LRB- cord-348409-oxjd263z 37 27 14 14 CD cord-348409-oxjd263z 37 28 ] ] -RRB- cord-348409-oxjd263z 37 29 , , , cord-348409-oxjd263z 37 30 although although IN cord-348409-oxjd263z 37 31 there there EX cord-348409-oxjd263z 37 32 are be VBP cord-348409-oxjd263z 37 33 slight slight JJ cord-348409-oxjd263z 37 34 variations variation NNS cord-348409-oxjd263z 37 35 between between IN cord-348409-oxjd263z 37 36 the the DT cord-348409-oxjd263z 37 37 genomes genome NNS cord-348409-oxjd263z 37 38 . . . cord-348409-oxjd263z 38 1 There there EX cord-348409-oxjd263z 38 2 are be VBP cord-348409-oxjd263z 38 3 10 10 CD cord-348409-oxjd263z 38 4 genes gene NNS cord-348409-oxjd263z 38 5 and and CC cord-348409-oxjd263z 38 6 a a DT cord-348409-oxjd263z 38 7 non non JJ cord-348409-oxjd263z 38 8 - - JJ cord-348409-oxjd263z 38 9 coding coding JJ cord-348409-oxjd263z 38 10 intergenic intergenic JJ cord-348409-oxjd263z 38 11 region region NN cord-348409-oxjd263z 38 12 which which WDT cord-348409-oxjd263z 38 13 are be VBP cord-348409-oxjd263z 38 14 conserved conserve VBN cord-348409-oxjd263z 38 15 across across IN cord-348409-oxjd263z 38 16 the the DT cord-348409-oxjd263z 38 17 Ff Ff NNP cord-348409-oxjd263z 38 18 species specie NNS cord-348409-oxjd263z 38 19 [ [ -LRB- cord-348409-oxjd263z 38 20 15 15 CD cord-348409-oxjd263z 38 21 ] ] -RRB- cord-348409-oxjd263z 38 22 [ [ -LRB- cord-348409-oxjd263z 38 23 16 16 CD cord-348409-oxjd263z 38 24 ] ] -RRB- cord-348409-oxjd263z 38 25 [ [ -LRB- cord-348409-oxjd263z 38 26 17 17 CD cord-348409-oxjd263z 38 27 ] ] -RRB- cord-348409-oxjd263z 38 28 as as RB cord-348409-oxjd263z 38 29 well well RB cord-348409-oxjd263z 38 30 as as IN cord-348409-oxjd263z 38 31 DNA dna NN cord-348409-oxjd263z 38 32 replication replication NN cord-348409-oxjd263z 38 33 and and CC cord-348409-oxjd263z 38 34 transcriptional transcriptional JJ cord-348409-oxjd263z 38 35 machinery machinery NN cord-348409-oxjd263z 38 36 ( ( -LRB- cord-348409-oxjd263z 38 37 for for IN cord-348409-oxjd263z 38 38 a a DT cord-348409-oxjd263z 38 39 recent recent JJ cord-348409-oxjd263z 38 40 review review NN cord-348409-oxjd263z 38 41 see see VBP cord-348409-oxjd263z 38 42 [ [ -LRB- cord-348409-oxjd263z 38 43 10 10 CD cord-348409-oxjd263z 38 44 ] ] -RRB- cord-348409-oxjd263z 38 45 ) ) -RRB- cord-348409-oxjd263z 38 46 . . . cord-348409-oxjd263z 39 1 Proteins protein NNS cord-348409-oxjd263z 39 2 are be VBP cord-348409-oxjd263z 39 3 encoded encode VBN cord-348409-oxjd263z 39 4 by by IN cord-348409-oxjd263z 39 5 5 5 CD cord-348409-oxjd263z 39 6 genes gene NNS cord-348409-oxjd263z 39 7 in in IN cord-348409-oxjd263z 39 8 the the DT cord-348409-oxjd263z 39 9 virion virion NN cord-348409-oxjd263z 39 10 ( ( -LRB- cord-348409-oxjd263z 39 11 g3 g3 NNP cord-348409-oxjd263z 39 12 , , , cord-348409-oxjd263z 39 13 g6 g6 NNP cord-348409-oxjd263z 39 14 , , , cord-348409-oxjd263z 39 15 g7 g7 NNP cord-348409-oxjd263z 39 16 , , , cord-348409-oxjd263z 39 17 g8 g8 NNP cord-348409-oxjd263z 39 18 , , , cord-348409-oxjd263z 39 19 and and CC cord-348409-oxjd263z 39 20 g9 g9 NNP cord-348409-oxjd263z 39 21 ) ) -RRB- cord-348409-oxjd263z 39 22 . . . cord-348409-oxjd263z 40 1 Gene gene NN cord-348409-oxjd263z 40 2 8 8 CD cord-348409-oxjd263z 40 3 proteins protein NNS cord-348409-oxjd263z 40 4 ( ( -LRB- cord-348409-oxjd263z 40 5 gp8 gp8 NNP cord-348409-oxjd263z 40 6 ) ) -RRB- cord-348409-oxjd263z 40 7 , , , cord-348409-oxjd263z 40 8 the the DT cord-348409-oxjd263z 40 9 major major JJ cord-348409-oxjd263z 40 10 coat coat NN cord-348409-oxjd263z 40 11 protein protein NN cord-348409-oxjd263z 40 12 , , , cord-348409-oxjd263z 40 13 make make VB cord-348409-oxjd263z 40 14 up up RP cord-348409-oxjd263z 40 15 the the DT cord-348409-oxjd263z 40 16 vast vast JJ cord-348409-oxjd263z 40 17 majority majority NN cord-348409-oxjd263z 40 18 of of IN cord-348409-oxjd263z 40 19 the the DT cord-348409-oxjd263z 40 20 virion virion NN cord-348409-oxjd263z 40 21 , , , cord-348409-oxjd263z 40 22 occurring occur VBG cord-348409-oxjd263z 40 23 in in IN cord-348409-oxjd263z 40 24 fivefold fivefold JJ cord-348409-oxjd263z 40 25 axial axial JJ cord-348409-oxjd263z 40 26 symmetry symmetry NN cord-348409-oxjd263z 40 27 . . . cord-348409-oxjd263z 41 1 Gene gene NN cord-348409-oxjd263z 41 2 proteins protein NNS cord-348409-oxjd263z 41 3 3 3 CD cord-348409-oxjd263z 41 4 and and CC cord-348409-oxjd263z 41 5 6 6 CD cord-348409-oxjd263z 42 1 ( ( -LRB- cord-348409-oxjd263z 42 2 gp3 gp3 NNP cord-348409-oxjd263z 42 3 and and CC cord-348409-oxjd263z 42 4 gp6 gp6 NNP cord-348409-oxjd263z 42 5 ) ) -RRB- cord-348409-oxjd263z 42 6 are be VBP cord-348409-oxjd263z 42 7 located locate VBN cord-348409-oxjd263z 42 8 on on IN cord-348409-oxjd263z 42 9 the the DT cord-348409-oxjd263z 42 10 proximal proximal JJ cord-348409-oxjd263z 42 11 end end NN cord-348409-oxjd263z 42 12 of of IN cord-348409-oxjd263z 42 13 the the DT cord-348409-oxjd263z 42 14 virion virion NN cord-348409-oxjd263z 42 15 and and CC cord-348409-oxjd263z 42 16 are be VBP cord-348409-oxjd263z 42 17 involved involve VBN cord-348409-oxjd263z 42 18 in in IN cord-348409-oxjd263z 42 19 stabilization stabilization NN cord-348409-oxjd263z 42 20 and and CC cord-348409-oxjd263z 42 21 infecting infect VBG cord-348409-oxjd263z 42 22 the the DT cord-348409-oxjd263z 42 23 host host NN cord-348409-oxjd263z 42 24 cell cell NN cord-348409-oxjd263z 42 25 . . . cord-348409-oxjd263z 43 1 Gene gene NN cord-348409-oxjd263z 43 2 proteins protein NNS cord-348409-oxjd263z 43 3 7 7 CD cord-348409-oxjd263z 43 4 and and CC cord-348409-oxjd263z 43 5 9 9 CD cord-348409-oxjd263z 44 1 ( ( -LRB- cord-348409-oxjd263z 44 2 gp7 gp7 NN cord-348409-oxjd263z 44 3 and and CC cord-348409-oxjd263z 44 4 gp9 gp9 JJ cord-348409-oxjd263z 44 5 ) ) -RRB- cord-348409-oxjd263z 44 6 are be VBP cord-348409-oxjd263z 44 7 on on IN cord-348409-oxjd263z 44 8 the the DT cord-348409-oxjd263z 44 9 distal distal JJ cord-348409-oxjd263z 44 10 end end NN cord-348409-oxjd263z 44 11 of of IN cord-348409-oxjd263z 44 12 the the DT cord-348409-oxjd263z 44 13 virion virion NN cord-348409-oxjd263z 44 14 and and CC cord-348409-oxjd263z 44 15 perform perform VB cord-348409-oxjd263z 44 16 initiation initiation NN cord-348409-oxjd263z 44 17 assembly assembly NN cord-348409-oxjd263z 44 18 [ [ -LRB- cord-348409-oxjd263z 44 19 18 18 CD cord-348409-oxjd263z 44 20 ] ] -RRB- cord-348409-oxjd263z 45 1 [ [ -LRB- cord-348409-oxjd263z 45 2 19 19 CD cord-348409-oxjd263z 45 3 ] ] -RRB- cord-348409-oxjd263z 45 4 [ [ -LRB- cord-348409-oxjd263z 45 5 20 20 CD cord-348409-oxjd263z 45 6 ] ] -RRB- cord-348409-oxjd263z 45 7 . . . cord-348409-oxjd263z 46 1 As as IN cord-348409-oxjd263z 46 2 shown show VBN cord-348409-oxjd263z 46 3 in in IN cord-348409-oxjd263z 46 4 the the DT cord-348409-oxjd263z 46 5 end end NN cord-348409-oxjd263z 46 6 - - HYPH cord-348409-oxjd263z 46 7 to to IN cord-348409-oxjd263z 46 8 - - HYPH cord-348409-oxjd263z 46 9 end end NN cord-348409-oxjd263z 46 10 model model NN cord-348409-oxjd263z 46 11 in in IN cord-348409-oxjd263z 46 12 Figure figure NN cord-348409-oxjd263z 46 13 1 1 CD cord-348409-oxjd263z 46 14 ( ( -LRB- cord-348409-oxjd263z 46 15 a a LS cord-348409-oxjd263z 46 16 ) ) -RRB- cord-348409-oxjd263z 46 17 , , , cord-348409-oxjd263z 46 18 minor minor JJ cord-348409-oxjd263z 46 19 coat coat NN cord-348409-oxjd263z 46 20 protein protein NN cord-348409-oxjd263z 46 21 subunits subunit NNS cord-348409-oxjd263z 46 22 have have VBP cord-348409-oxjd263z 46 23 fivefold fivefold JJ cord-348409-oxjd263z 46 24 axial axial JJ cord-348409-oxjd263z 46 25 symmetry symmetry NN cord-348409-oxjd263z 46 26 . . . cord-348409-oxjd263z 47 1 While while IN cord-348409-oxjd263z 47 2 much much JJ cord-348409-oxjd263z 47 3 research research NN cord-348409-oxjd263z 47 4 has have VBZ cord-348409-oxjd263z 47 5 been be VBN cord-348409-oxjd263z 47 6 done do VBN cord-348409-oxjd263z 47 7 into into IN cord-348409-oxjd263z 47 8 the the DT cord-348409-oxjd263z 47 9 structure structure NN cord-348409-oxjd263z 47 10 of of IN cord-348409-oxjd263z 47 11 the the DT cord-348409-oxjd263z 47 12 Ff Ff NNP cord-348409-oxjd263z 47 13 virus virus NN cord-348409-oxjd263z 47 14 over over IN cord-348409-oxjd263z 47 15 the the DT cord-348409-oxjd263z 47 16 past past JJ cord-348409-oxjd263z 47 17 50 50 CD cord-348409-oxjd263z 47 18 years year NNS cord-348409-oxjd263z 47 19 , , , cord-348409-oxjd263z 47 20 a a DT cord-348409-oxjd263z 47 21 conclusive conclusive JJ cord-348409-oxjd263z 47 22 structure structure NN cord-348409-oxjd263z 47 23 has have VBZ cord-348409-oxjd263z 47 24 not not RB cord-348409-oxjd263z 47 25 been be VBN cord-348409-oxjd263z 47 26 determined determine VBN cord-348409-oxjd263z 47 27 since since IN cord-348409-oxjd263z 47 28 the the DT cord-348409-oxjd263z 47 29 viruses virus NNS cord-348409-oxjd263z 47 30 can can MD cord-348409-oxjd263z 47 31 not not RB cord-348409-oxjd263z 47 32 be be VB cord-348409-oxjd263z 47 33 crystallized crystallize VBN cord-348409-oxjd263z 47 34 . . . cord-348409-oxjd263z 48 1 X x NN cord-348409-oxjd263z 48 2 - - NN cord-348409-oxjd263z 48 3 ray ray JJ cord-348409-oxjd263z 48 4 fiber fiber NN cord-348409-oxjd263z 48 5 diffraction diffraction NN cord-348409-oxjd263z 48 6 studies study NNS cord-348409-oxjd263z 48 7 and and CC cord-348409-oxjd263z 48 8 physiochemical physiochemical JJ cord-348409-oxjd263z 48 9 measurements measurement NNS cord-348409-oxjd263z 48 10 have have VBP cord-348409-oxjd263z 48 11 revealed reveal VBN cord-348409-oxjd263z 48 12 the the DT cord-348409-oxjd263z 48 13 five five CD cord-348409-oxjd263z 48 14 - - HYPH cord-348409-oxjd263z 48 15 star star NN cord-348409-oxjd263z 48 16 helical helical JJ cord-348409-oxjd263z 48 17 symmetry symmetry NN cord-348409-oxjd263z 48 18 ( ( -LRB- cord-348409-oxjd263z 48 19 5fold 5fold CD cord-348409-oxjd263z 48 20 rotation rotation NN cord-348409-oxjd263z 48 21 axis axis NN cord-348409-oxjd263z 48 22 ) ) -RRB- cord-348409-oxjd263z 48 23 of of IN cord-348409-oxjd263z 48 24 the the DT cord-348409-oxjd263z 48 25 gp8 gp8 JJ cord-348409-oxjd263z 48 26 subunit subunit NNP cord-348409-oxjd263z 48 27 and and CC cord-348409-oxjd263z 48 28 are be VBP cord-348409-oxjd263z 48 29 referred refer VBN cord-348409-oxjd263z 48 30 to to IN cord-348409-oxjd263z 48 31 as as IN cord-348409-oxjd263z 48 32 Class class NN cord-348409-oxjd263z 49 1 I -PRON- PRP cord-348409-oxjd263z 49 2 [ [ -LRB- cord-348409-oxjd263z 49 3 21 21 CD cord-348409-oxjd263z 49 4 ] ] -RRB- cord-348409-oxjd263z 49 5 [ [ -LRB- cord-348409-oxjd263z 49 6 22 22 CD cord-348409-oxjd263z 49 7 ] ] -RRB- cord-348409-oxjd263z 49 8 [ [ -LRB- cord-348409-oxjd263z 49 9 23 23 CD cord-348409-oxjd263z 49 10 ] ] -RRB- cord-348409-oxjd263z 49 11 . . . cord-348409-oxjd263z 50 1 However however RB cord-348409-oxjd263z 50 2 , , , cord-348409-oxjd263z 50 3 the the DT cord-348409-oxjd263z 50 4 structure structure NN cord-348409-oxjd263z 50 5 of of IN cord-348409-oxjd263z 50 6 the the DT cord-348409-oxjd263z 50 7 ssDNA ssdna NN cord-348409-oxjd263z 50 8 and and CC cord-348409-oxjd263z 50 9 its -PRON- PRP$ cord-348409-oxjd263z 50 10 relationship relationship NN cord-348409-oxjd263z 50 11 to to IN cord-348409-oxjd263z 50 12 the the DT cord-348409-oxjd263z 50 13 protein protein NN cord-348409-oxjd263z 50 14 sheath sheath NN cord-348409-oxjd263z 50 15 is be VBZ cord-348409-oxjd263z 50 16 poorly poorly RB cord-348409-oxjd263z 50 17 understood understand VBN cord-348409-oxjd263z 50 18 , , , cord-348409-oxjd263z 50 19 due due IN cord-348409-oxjd263z 50 20 to to IN cord-348409-oxjd263z 50 21 the the DT cord-348409-oxjd263z 50 22 small small JJ cord-348409-oxjd263z 50 23 amount amount NN cord-348409-oxjd263z 50 24 of of IN cord-348409-oxjd263z 50 25 DNA dna NN cord-348409-oxjd263z 50 26 in in IN cord-348409-oxjd263z 50 27 individual individual JJ cord-348409-oxjd263z 50 28 virions virion NNS cord-348409-oxjd263z 50 29 . . . cord-348409-oxjd263z 51 1 However however RB cord-348409-oxjd263z 51 2 , , , cord-348409-oxjd263z 51 3 the the DT cord-348409-oxjd263z 51 4 architecture architecture NN cord-348409-oxjd263z 51 5 is be VBZ cord-348409-oxjd263z 51 6 sufficiently sufficiently RB cord-348409-oxjd263z 51 7 understood understand VBN cord-348409-oxjd263z 51 8 to to TO cord-348409-oxjd263z 51 9 take take VB cord-348409-oxjd263z 51 10 advantage advantage NN cord-348409-oxjd263z 51 11 of of IN cord-348409-oxjd263z 51 12 the the DT cord-348409-oxjd263z 51 13 structures structure NNS cord-348409-oxjd263z 51 14 and and CC cord-348409-oxjd263z 51 15 capabilities capability NNS cord-348409-oxjd263z 51 16 of of IN cord-348409-oxjd263z 51 17 the the DT cord-348409-oxjd263z 51 18 virus virus NN cord-348409-oxjd263z 51 19 throughout throughout IN cord-348409-oxjd263z 51 20 its -PRON- PRP$ cord-348409-oxjd263z 51 21 life life NN cord-348409-oxjd263z 51 22 cycle cycle NN cord-348409-oxjd263z 51 23 . . . cord-348409-oxjd263z 52 1 The the DT cord-348409-oxjd263z 52 2 life life NN cord-348409-oxjd263z 52 3 cycle cycle NN cord-348409-oxjd263z 52 4 of of IN cord-348409-oxjd263z 52 5 Ff Ff NNP cord-348409-oxjd263z 52 6 filamentous filamentous JJ cord-348409-oxjd263z 52 7 viruses virus NNS cord-348409-oxjd263z 52 8 begins begin VBZ cord-348409-oxjd263z 52 9 when when WRB cord-348409-oxjd263z 52 10 an an DT cord-348409-oxjd263z 52 11 adsorption adsorption NN cord-348409-oxjd263z 52 12 structure structure NN cord-348409-oxjd263z 52 13 on on IN cord-348409-oxjd263z 52 14 the the DT cord-348409-oxjd263z 52 15 proximal proximal JJ cord-348409-oxjd263z 52 16 end end NN cord-348409-oxjd263z 52 17 of of IN cord-348409-oxjd263z 52 18 the the DT cord-348409-oxjd263z 52 19 virus virus NN cord-348409-oxjd263z 52 20 is be VBZ cord-348409-oxjd263z 52 21 adsorbed adsorb VBN cord-348409-oxjd263z 52 22 to to IN cord-348409-oxjd263z 52 23 the the DT cord-348409-oxjd263z 52 24 tip tip NN cord-348409-oxjd263z 52 25 of of IN cord-348409-oxjd263z 52 26 the the DT cord-348409-oxjd263z 52 27 F F NNP cord-348409-oxjd263z 52 28 + + CC cord-348409-oxjd263z 52 29 specific specific JJ cord-348409-oxjd263z 52 30 pilus pilus NN cord-348409-oxjd263z 52 31 of of IN cord-348409-oxjd263z 52 32 E. E. NNP cord-348409-oxjd263z 52 33 coli coli NNS cord-348409-oxjd263z 52 34 . . . cord-348409-oxjd263z 53 1 Following follow VBG cord-348409-oxjd263z 53 2 binding bind VBG cord-348409-oxjd263z 53 3 between between IN cord-348409-oxjd263z 53 4 the the DT cord-348409-oxjd263z 53 5 virus virus NN cord-348409-oxjd263z 53 6 and and CC cord-348409-oxjd263z 53 7 the the DT cord-348409-oxjd263z 53 8 bacterial bacterial JJ cord-348409-oxjd263z 53 9 cell cell NN cord-348409-oxjd263z 53 10 ( ( -LRB- cord-348409-oxjd263z 53 11 for for IN cord-348409-oxjd263z 53 12 a a DT cord-348409-oxjd263z 53 13 recent recent JJ cord-348409-oxjd263z 53 14 review review NN cord-348409-oxjd263z 53 15 , , , cord-348409-oxjd263z 53 16 see see VB cord-348409-oxjd263z 53 17 [ [ -LRB- cord-348409-oxjd263z 53 18 10 10 CD cord-348409-oxjd263z 53 19 ] ] -RRB- cord-348409-oxjd263z 53 20 ) ) -RRB- cord-348409-oxjd263z 53 21 , , , cord-348409-oxjd263z 53 22 the the DT cord-348409-oxjd263z 53 23 major major JJ cord-348409-oxjd263z 53 24 coat coat NN cord-348409-oxjd263z 53 25 proteins protein NNS cord-348409-oxjd263z 53 26 of of IN cord-348409-oxjd263z 53 27 the the DT cord-348409-oxjd263z 53 28 Article Article NNP cord-348409-oxjd263z 53 29 Highlights Highlights NNPS cord-348409-oxjd263z 54 1 • • NNP cord-348409-oxjd263z 55 1 Inoviruses Inoviruses NNP cord-348409-oxjd263z 55 2 are be VBP cord-348409-oxjd263z 55 3 easily easily RB cord-348409-oxjd263z 55 4 manipulated manipulate VBN cord-348409-oxjd263z 55 5 viruses virus NNS cord-348409-oxjd263z 55 6 which which WDT cord-348409-oxjd263z 55 7 coexist coexist VBP cord-348409-oxjd263z 55 8 with with IN cord-348409-oxjd263z 55 9 their -PRON- PRP$ cord-348409-oxjd263z 55 10 host host NN cord-348409-oxjd263z 55 11 while while IN cord-348409-oxjd263z 55 12 causing cause VBG cord-348409-oxjd263z 55 13 minimal minimal JJ cord-348409-oxjd263z 55 14 harm harm NN cord-348409-oxjd263z 55 15 and and CC cord-348409-oxjd263z 55 16 are be VBP cord-348409-oxjd263z 55 17 highly highly RB cord-348409-oxjd263z 55 18 reproducible reproducible JJ cord-348409-oxjd263z 55 19 . . . cord-348409-oxjd263z 56 1 • • NNP cord-348409-oxjd263z 57 1 Simple simple JJ cord-348409-oxjd263z 57 2 genetic genetic JJ cord-348409-oxjd263z 57 3 manipulation manipulation NN cord-348409-oxjd263z 57 4 makes make VBZ cord-348409-oxjd263z 57 5 the the DT cord-348409-oxjd263z 57 6 insertion insertion NN cord-348409-oxjd263z 57 7 of of IN cord-348409-oxjd263z 57 8 random random JJ cord-348409-oxjd263z 57 9 or or CC cord-348409-oxjd263z 57 10 specific specific JJ cord-348409-oxjd263z 57 11 oligonucleotides oligonucleotide NNS cord-348409-oxjd263z 57 12 into into IN cord-348409-oxjd263z 57 13 the the DT cord-348409-oxjd263z 57 14 inovirus inovirus NNP cord-348409-oxjd263z 57 15 genome genome NN cord-348409-oxjd263z 57 16 . . . cord-348409-oxjd263z 58 1 These these DT cord-348409-oxjd263z 58 2 genetically genetically RB cord-348409-oxjd263z 58 3 modified modify VBN cord-348409-oxjd263z 58 4 inoviruses inoviruse NNS cord-348409-oxjd263z 58 5 can can MD cord-348409-oxjd263z 58 6 display display VB cord-348409-oxjd263z 58 7 corresponding correspond VBG cord-348409-oxjd263z 58 8 oligopeptides oligopeptide NNS cord-348409-oxjd263z 58 9 as as IN cord-348409-oxjd263z 58 10 fusion fusion NN cord-348409-oxjd263z 58 11 proteins protein NNS cord-348409-oxjd263z 58 12 on on IN cord-348409-oxjd263z 58 13 their -PRON- PRP$ cord-348409-oxjd263z 58 14 surface surface NN cord-348409-oxjd263z 58 15 and and CC cord-348409-oxjd263z 58 16 are be VBP cord-348409-oxjd263z 58 17 referred refer VBN cord-348409-oxjd263z 58 18 to to IN cord-348409-oxjd263z 58 19 as as IN cord-348409-oxjd263z 58 20 inovirusassociated inovirusassociate VBN cord-348409-oxjd263z 58 21 vectors vector NNS cord-348409-oxjd263z 58 22 ( ( -LRB- cord-348409-oxjd263z 58 23 IAVs IAVs NNP cord-348409-oxjd263z 58 24 ) ) -RRB- cord-348409-oxjd263z 58 25 . . . cord-348409-oxjd263z 59 1 • • NNP cord-348409-oxjd263z 60 1 IAVs iav NNS cord-348409-oxjd263z 60 2 displaying display VBG cord-348409-oxjd263z 60 3 randomly randomly RB cord-348409-oxjd263z 60 4 generated generate VBN cord-348409-oxjd263z 60 5 oligopeptides oligopeptide NNS cord-348409-oxjd263z 60 6 are be VBP cord-348409-oxjd263z 60 7 used use VBN cord-348409-oxjd263z 60 8 to to TO cord-348409-oxjd263z 60 9 identify identify VB cord-348409-oxjd263z 60 10 the the DT cord-348409-oxjd263z 60 11 epitopes epitope NNS cord-348409-oxjd263z 60 12 of of IN cord-348409-oxjd263z 60 13 specific specific JJ cord-348409-oxjd263z 60 14 antibodies antibody NNS cord-348409-oxjd263z 60 15 through through IN cord-348409-oxjd263z 60 16 biopanning biopanning NN cord-348409-oxjd263z 60 17 . . . cord-348409-oxjd263z 61 1 By by IN cord-348409-oxjd263z 61 2 isolating isolate VBG cord-348409-oxjd263z 61 3 recombinant recombinant JJ cord-348409-oxjd263z 61 4 inoviruses inoviruses NNP cord-348409-oxjd263z 61 5 displaying display VBG cord-348409-oxjd263z 61 6 mimotypes mimotypes NNP cord-348409-oxjd263z 61 7 resembling resemble VBG cord-348409-oxjd263z 61 8 an an DT cord-348409-oxjd263z 61 9 antibody antibody NN cord-348409-oxjd263z 61 10 discontinuous discontinuous JJ cord-348409-oxjd263z 61 11 target target NN cord-348409-oxjd263z 61 12 epitope epitope NN cord-348409-oxjd263z 61 13 , , , cord-348409-oxjd263z 61 14 the the DT cord-348409-oxjd263z 61 15 DNA dna NN cord-348409-oxjd263z 61 16 and and CC cord-348409-oxjd263z 61 17 amino amino NN cord-348409-oxjd263z 61 18 acid acid NN cord-348409-oxjd263z 61 19 sequence sequence NN cord-348409-oxjd263z 61 20 of of IN cord-348409-oxjd263z 61 21 the the DT cord-348409-oxjd263z 61 22 oligopeptides oligopeptide NNS cord-348409-oxjd263z 61 23 of of IN cord-348409-oxjd263z 61 24 interest interest NN cord-348409-oxjd263z 61 25 can can MD cord-348409-oxjd263z 61 26 be be VB cord-348409-oxjd263z 61 27 determined determine VBN cord-348409-oxjd263z 61 28 . . . cord-348409-oxjd263z 62 1 • • NNP cord-348409-oxjd263z 63 1 IAVs iav NNS cord-348409-oxjd263z 63 2 have have VBP cord-348409-oxjd263z 63 3 bene bene NNP cord-348409-oxjd263z 63 4 used use VBN cord-348409-oxjd263z 63 5 to to TO cord-348409-oxjd263z 63 6 do do VB cord-348409-oxjd263z 63 7 create create VB cord-348409-oxjd263z 63 8 vaccines vaccine NNS cord-348409-oxjd263z 63 9 against against IN cord-348409-oxjd263z 63 10 a a DT cord-348409-oxjd263z 63 11 variety variety NN cord-348409-oxjd263z 63 12 of of IN cord-348409-oxjd263z 63 13 infectious infectious JJ cord-348409-oxjd263z 63 14 and and CC cord-348409-oxjd263z 63 15 non non JJ cord-348409-oxjd263z 63 16 - - JJ cord-348409-oxjd263z 63 17 infectious infectious JJ cord-348409-oxjd263z 63 18 diseases disease NNS cord-348409-oxjd263z 63 19 , , , cord-348409-oxjd263z 63 20 being be VBG cord-348409-oxjd263z 63 21 used use VBN cord-348409-oxjd263z 63 22 both both CC cord-348409-oxjd263z 63 23 to to IN cord-348409-oxjd263z 63 24 the the DT cord-348409-oxjd263z 63 25 screen screen NN cord-348409-oxjd263z 63 26 for for IN cord-348409-oxjd263z 63 27 immunogenic immunogenic JJ cord-348409-oxjd263z 63 28 peptides peptide NNS cord-348409-oxjd263z 63 29 and and CC cord-348409-oxjd263z 63 30 directly directly RB cord-348409-oxjd263z 63 31 present present JJ cord-348409-oxjd263z 63 32 immunogenic immunogenic JJ cord-348409-oxjd263z 63 33 peptides peptide NNS cord-348409-oxjd263z 63 34 to to IN cord-348409-oxjd263z 63 35 the the DT cord-348409-oxjd263z 63 36 organism organism NN cord-348409-oxjd263z 63 37 to to TO cord-348409-oxjd263z 63 38 elicit elicit VB cord-348409-oxjd263z 63 39 proper proper JJ cord-348409-oxjd263z 63 40 antibody antibody NN cord-348409-oxjd263z 63 41 production production NN cord-348409-oxjd263z 63 42 . . . cord-348409-oxjd263z 64 1 • • NNP cord-348409-oxjd263z 65 1 IAVs iav NNS cord-348409-oxjd263z 65 2 are be VBP cord-348409-oxjd263z 65 3 highly highly RB cord-348409-oxjd263z 65 4 immunogenic immunogenic JJ cord-348409-oxjd263z 65 5 , , , cord-348409-oxjd263z 65 6 can can MD cord-348409-oxjd263z 65 7 stimulate stimulate VB cord-348409-oxjd263z 65 8 both both DT cord-348409-oxjd263z 65 9 humoral humoral JJ cord-348409-oxjd263z 65 10 and and CC cord-348409-oxjd263z 65 11 cellular cellular JJ cord-348409-oxjd263z 65 12 responses response NNS cord-348409-oxjd263z 65 13 in in IN cord-348409-oxjd263z 65 14 a a DT cord-348409-oxjd263z 65 15 variety variety NN cord-348409-oxjd263z 65 16 of of IN cord-348409-oxjd263z 65 17 diseases disease NNS cord-348409-oxjd263z 65 18 , , , cord-348409-oxjd263z 65 19 pose pose VBP cord-348409-oxjd263z 65 20 no no DT cord-348409-oxjd263z 65 21 known know VBN cord-348409-oxjd263z 65 22 health health NN cord-348409-oxjd263z 65 23 risks risk NNS cord-348409-oxjd263z 65 24 , , , cord-348409-oxjd263z 65 25 and and CC cord-348409-oxjd263z 65 26 are be VBP cord-348409-oxjd263z 65 27 cost cost VBN cord-348409-oxjd263z 65 28 - - HYPH cord-348409-oxjd263z 65 29 efficient efficient JJ cord-348409-oxjd263z 65 30 to to TO cord-348409-oxjd263z 65 31 produce produce VB cord-348409-oxjd263z 65 32 . . . cord-348409-oxjd263z 66 1 This this DT cord-348409-oxjd263z 66 2 box box NN cord-348409-oxjd263z 66 3 summarizes summarize VBZ cord-348409-oxjd263z 66 4 key key JJ cord-348409-oxjd263z 66 5 points point NNS cord-348409-oxjd263z 66 6 contained contain VBN cord-348409-oxjd263z 66 7 in in IN cord-348409-oxjd263z 66 8 the the DT cord-348409-oxjd263z 66 9 article article NN cord-348409-oxjd263z 66 10 . . . cord-348409-oxjd263z 67 1 virus virus NN cord-348409-oxjd263z 67 2 become become VBP cord-348409-oxjd263z 67 3 associated associate VBN cord-348409-oxjd263z 67 4 with with IN cord-348409-oxjd263z 67 5 the the DT cord-348409-oxjd263z 67 6 inner inner JJ cord-348409-oxjd263z 67 7 membrane membrane NN cord-348409-oxjd263z 67 8 of of IN cord-348409-oxjd263z 67 9 the the DT cord-348409-oxjd263z 67 10 cell cell NN cord-348409-oxjd263z 67 11 [ [ -LRB- cord-348409-oxjd263z 67 12 24 24 CD cord-348409-oxjd263z 67 13 ] ] -RRB- cord-348409-oxjd263z 67 14 [ [ -LRB- cord-348409-oxjd263z 67 15 25 25 CD cord-348409-oxjd263z 67 16 ] ] -RRB- cord-348409-oxjd263z 67 17 [ [ -LRB- cord-348409-oxjd263z 67 18 26 26 CD cord-348409-oxjd263z 67 19 ] ] -RRB- cord-348409-oxjd263z 67 20 . . . cord-348409-oxjd263z 68 1 The the DT cord-348409-oxjd263z 68 2 virion virion NN cord-348409-oxjd263z 68 3 's 's POS cord-348409-oxjd263z 68 4 circular circular JJ cord-348409-oxjd263z 68 5 single single RB cord-348409-oxjd263z 68 6 - - HYPH cord-348409-oxjd263z 68 7 stranded strand VBN cord-348409-oxjd263z 68 8 DNA dna NN cord-348409-oxjd263z 68 9 ( ( -LRB- cord-348409-oxjd263z 68 10 cssDNA cssDNA NNP cord-348409-oxjd263z 68 11 ) ) -RRB- cord-348409-oxjd263z 68 12 is be VBZ cord-348409-oxjd263z 68 13 then then RB cord-348409-oxjd263z 68 14 ejected eject VBN cord-348409-oxjd263z 68 15 into into IN cord-348409-oxjd263z 68 16 the the DT cord-348409-oxjd263z 68 17 cytoplasm cytoplasm NN cord-348409-oxjd263z 68 18 where where WRB cord-348409-oxjd263z 68 19 it -PRON- PRP cord-348409-oxjd263z 68 20 is be VBZ cord-348409-oxjd263z 68 21 converted convert VBN cord-348409-oxjd263z 68 22 to to IN cord-348409-oxjd263z 68 23 a a DT cord-348409-oxjd263z 68 24 parental parental JJ cord-348409-oxjd263z 68 25 double double RB cord-348409-oxjd263z 68 26 - - HYPH cord-348409-oxjd263z 68 27 stranded strand VBN cord-348409-oxjd263z 68 28 replicative replicative JJ cord-348409-oxjd263z 68 29 form form NN cord-348409-oxjd263z 68 30 ( ( -LRB- cord-348409-oxjd263z 68 31 RF rf NN cord-348409-oxjd263z 68 32 ) ) -RRB- cord-348409-oxjd263z 68 33 . . . cord-348409-oxjd263z 69 1 Using use VBG cord-348409-oxjd263z 69 2 a a DT cord-348409-oxjd263z 69 3 rollingcircle rollingcircle NN cord-348409-oxjd263z 69 4 mechanism mechanism NN cord-348409-oxjd263z 69 5 , , , cord-348409-oxjd263z 69 6 Ff Ff NNP cord-348409-oxjd263z 69 7 inoviruses inoviruse NNS cord-348409-oxjd263z 69 8 replicate replicate VBP cord-348409-oxjd263z 69 9 their -PRON- PRP$ cord-348409-oxjd263z 69 10 genome genome NN cord-348409-oxjd263z 69 11 . . . cord-348409-oxjd263z 70 1 The the DT cord-348409-oxjd263z 70 2 new new JJ cord-348409-oxjd263z 70 3 virion virion NN cord-348409-oxjd263z 70 4 is be VBZ cord-348409-oxjd263z 70 5 assembled assemble VBN cord-348409-oxjd263z 70 6 through through IN cord-348409-oxjd263z 70 7 a a DT cord-348409-oxjd263z 70 8 complex complex JJ cord-348409-oxjd263z 70 9 set set NN cord-348409-oxjd263z 70 10 of of IN cord-348409-oxjd263z 70 11 interactions interaction NNS cord-348409-oxjd263z 70 12 that that WDT cord-348409-oxjd263z 70 13 binds bind VBZ cord-348409-oxjd263z 70 14 the the DT cord-348409-oxjd263z 70 15 protein protein NN cord-348409-oxjd263z 70 16 subunits subunit NNS cord-348409-oxjd263z 70 17 to to IN cord-348409-oxjd263z 70 18 the the DT cord-348409-oxjd263z 70 19 ssDNA ssdna NN cord-348409-oxjd263z 70 20 [ [ -LRB- cord-348409-oxjd263z 70 21 15 15 CD cord-348409-oxjd263z 70 22 ] ] -RRB- cord-348409-oxjd263z 70 23 [ [ -LRB- cord-348409-oxjd263z 70 24 16 16 CD cord-348409-oxjd263z 70 25 ] ] -RRB- cord-348409-oxjd263z 70 26 [ [ -LRB- cord-348409-oxjd263z 70 27 17 17 CD cord-348409-oxjd263z 70 28 ] ] -RRB- cord-348409-oxjd263z 70 29 and and CC cord-348409-oxjd263z 70 30 embeds embed VBZ cord-348409-oxjd263z 70 31 newly newly RB cord-348409-oxjd263z 70 32 synthesized synthesize VBN cord-348409-oxjd263z 70 33 coat coat NN cord-348409-oxjd263z 70 34 proteins protein NNS cord-348409-oxjd263z 70 35 into into IN cord-348409-oxjd263z 70 36 the the DT cord-348409-oxjd263z 70 37 bacterial bacterial JJ cord-348409-oxjd263z 70 38 membrane membrane NN cord-348409-oxjd263z 70 39 [ [ -LRB- cord-348409-oxjd263z 70 40 27 27 CD cord-348409-oxjd263z 70 41 ] ] -RRB- cord-348409-oxjd263z 70 42 [ [ -LRB- cord-348409-oxjd263z 70 43 28 28 CD cord-348409-oxjd263z 70 44 ] ] -RRB- cord-348409-oxjd263z 70 45 [ [ -LRB- cord-348409-oxjd263z 70 46 29 29 CD cord-348409-oxjd263z 70 47 ] ] -RRB- cord-348409-oxjd263z 70 48 . . . cord-348409-oxjd263z 71 1 ssDNA ssDNA NNP cord-348409-oxjd263z 71 2 is be VBZ cord-348409-oxjd263z 71 3 passed pass VBN cord-348409-oxjd263z 71 4 through through IN cord-348409-oxjd263z 71 5 the the DT cord-348409-oxjd263z 71 6 mature mature JJ cord-348409-oxjd263z 71 7 coat coat NN cord-348409-oxjd263z 71 8 protein protein NN cord-348409-oxjd263z 71 9 , , , cord-348409-oxjd263z 71 10 spanning span VBG cord-348409-oxjd263z 71 11 the the DT cord-348409-oxjd263z 71 12 bacterial bacterial JJ cord-348409-oxjd263z 71 13 membrane membrane NN cord-348409-oxjd263z 71 14 , , , cord-348409-oxjd263z 71 15 and and CC cord-348409-oxjd263z 71 16 additional additional JJ cord-348409-oxjd263z 71 17 coat coat NN cord-348409-oxjd263z 71 18 proteins protein NNS cord-348409-oxjd263z 71 19 are be VBP cord-348409-oxjd263z 71 20 added add VBN cord-348409-oxjd263z 71 21 on on IN cord-348409-oxjd263z 71 22 the the DT cord-348409-oxjd263z 71 23 internal internal JJ cord-348409-oxjd263z 71 24 edge edge NN cord-348409-oxjd263z 71 25 of of IN cord-348409-oxjd263z 71 26 the the DT cord-348409-oxjd263z 71 27 membrane membrane NN cord-348409-oxjd263z 71 28 . . . cord-348409-oxjd263z 72 1 Additional additional JJ cord-348409-oxjd263z 72 2 proteins protein NNS cord-348409-oxjd263z 72 3 are be VBP cord-348409-oxjd263z 72 4 used use VBN cord-348409-oxjd263z 72 5 to to TO cord-348409-oxjd263z 72 6 package package VB cord-348409-oxjd263z 72 7 the the DT cord-348409-oxjd263z 72 8 inovirus inovirus NNP cord-348409-oxjd263z 72 9 and and CC cord-348409-oxjd263z 72 10 release release VB cord-348409-oxjd263z 72 11 it -PRON- PRP cord-348409-oxjd263z 72 12 into into IN cord-348409-oxjd263z 72 13 the the DT cord-348409-oxjd263z 72 14 cell cell NN cord-348409-oxjd263z 72 15 [ [ -LRB- cord-348409-oxjd263z 72 16 23 23 CD cord-348409-oxjd263z 72 17 , , , cord-348409-oxjd263z 72 18 30 30 CD cord-348409-oxjd263z 72 19 ] ] -RRB- cord-348409-oxjd263z 72 20 . . . cord-348409-oxjd263z 73 1 Inovirus Inovirus NNP cord-348409-oxjd263z 73 2 assembly assembly NN cord-348409-oxjd263z 73 3 on on IN cord-348409-oxjd263z 73 4 the the DT cord-348409-oxjd263z 73 5 inner inner JJ cord-348409-oxjd263z 73 6 membrane membrane NN cord-348409-oxjd263z 73 7 of of IN cord-348409-oxjd263z 73 8 the the DT cord-348409-oxjd263z 73 9 bacteria bacteria NNS cord-348409-oxjd263z 73 10 is be VBZ cord-348409-oxjd263z 73 11 a a DT cord-348409-oxjd263z 73 12 harmonized harmonize VBN cord-348409-oxjd263z 73 13 sequential sequential JJ cord-348409-oxjd263z 73 14 process process NN cord-348409-oxjd263z 73 15 with with IN cord-348409-oxjd263z 73 16 both both DT cord-348409-oxjd263z 73 17 viral viral RB cord-348409-oxjd263z 73 18 - - HYPH cord-348409-oxjd263z 73 19 encoded encode VBN cord-348409-oxjd263z 73 20 and and CC cord-348409-oxjd263z 73 21 host host NN cord-348409-oxjd263z 73 22 proteins protein NNS cord-348409-oxjd263z 73 23 playing play VBG cord-348409-oxjd263z 73 24 important important JJ cord-348409-oxjd263z 73 25 roles role NNS cord-348409-oxjd263z 73 26 . . . cord-348409-oxjd263z 74 1 For for IN cord-348409-oxjd263z 74 2 more more RBR cord-348409-oxjd263z 74 3 extensive extensive JJ cord-348409-oxjd263z 74 4 reviews review NNS cord-348409-oxjd263z 74 5 on on IN cord-348409-oxjd263z 74 6 inovirus inovirus NNP cord-348409-oxjd263z 74 7 life life NN cord-348409-oxjd263z 74 8 cycle cycle NN cord-348409-oxjd263z 74 9 and and CC cord-348409-oxjd263z 74 10 replication replication NN cord-348409-oxjd263z 74 11 , , , cord-348409-oxjd263z 74 12 see see VB cord-348409-oxjd263z 74 13 reviews review NNS cord-348409-oxjd263z 74 14 [ [ -LRB- cord-348409-oxjd263z 74 15 10 10 CD cord-348409-oxjd263z 74 16 , , , cord-348409-oxjd263z 74 17 31 31 CD cord-348409-oxjd263z 74 18 ] ] -RRB- cord-348409-oxjd263z 74 19 . . . cord-348409-oxjd263z 75 1 Importantly importantly RB cord-348409-oxjd263z 75 2 , , , cord-348409-oxjd263z 75 3 this this DT cord-348409-oxjd263z 75 4 process process NN cord-348409-oxjd263z 75 5 , , , cord-348409-oxjd263z 75 6 which which WDT cord-348409-oxjd263z 75 7 requires require VBZ cord-348409-oxjd263z 75 8 both both DT cord-348409-oxjd263z 75 9 virus virus NN cord-348409-oxjd263z 75 10 and and CC cord-348409-oxjd263z 75 11 host host NN cord-348409-oxjd263z 75 12 to to TO cord-348409-oxjd263z 75 13 complete complete VB cord-348409-oxjd263z 75 14 , , , cord-348409-oxjd263z 75 15 does do VBZ cord-348409-oxjd263z 75 16 not not RB cord-348409-oxjd263z 75 17 kill kill VB cord-348409-oxjd263z 75 18 the the DT cord-348409-oxjd263z 75 19 host host NN cord-348409-oxjd263z 75 20 , , , cord-348409-oxjd263z 75 21 making make VBG cord-348409-oxjd263z 75 22 inovirus inovirus NNP cord-348409-oxjd263z 75 23 replication replication VB cord-348409-oxjd263z 75 24 a a DT cord-348409-oxjd263z 75 25 sustainable sustainable JJ cord-348409-oxjd263z 75 26 process process NN cord-348409-oxjd263z 75 27 . . . cord-348409-oxjd263z 76 1 Inoviruses Inoviruses NNP cord-348409-oxjd263z 76 2 are be VBP cord-348409-oxjd263z 76 3 useful useful JJ cord-348409-oxjd263z 76 4 for for IN cord-348409-oxjd263z 76 5 vaccine vaccine NN cord-348409-oxjd263z 76 6 development development NN cord-348409-oxjd263z 76 7 because because IN cord-348409-oxjd263z 76 8 it -PRON- PRP cord-348409-oxjd263z 76 9 is be VBZ cord-348409-oxjd263z 76 10 possible possible JJ cord-348409-oxjd263z 76 11 to to TO cord-348409-oxjd263z 76 12 insert insert VB cord-348409-oxjd263z 76 13 random random JJ cord-348409-oxjd263z 76 14 oligonucleotides oligonucleotide NNS cord-348409-oxjd263z 76 15 into into IN cord-348409-oxjd263z 76 16 their -PRON- PRP$ cord-348409-oxjd263z 76 17 genome genome NN cord-348409-oxjd263z 76 18 . . . cord-348409-oxjd263z 77 1 This this DT cord-348409-oxjd263z 77 2 easy easy JJ cord-348409-oxjd263z 77 3 genetic genetic JJ cord-348409-oxjd263z 77 4 manipulation manipulation NN cord-348409-oxjd263z 77 5 is be VBZ cord-348409-oxjd263z 77 6 the the DT cord-348409-oxjd263z 77 7 basis basis NN cord-348409-oxjd263z 77 8 for for IN cord-348409-oxjd263z 77 9 inovirus inovirus NNP cord-348409-oxjd263z 77 10 display display NN cord-348409-oxjd263z 77 11 ( ( -LRB- cord-348409-oxjd263z 77 12 phage phage NN cord-348409-oxjd263z 77 13 display display NN cord-348409-oxjd263z 77 14 ) ) -RRB- cord-348409-oxjd263z 77 15 technology technology NN cord-348409-oxjd263z 77 16 [ [ -LRB- cord-348409-oxjd263z 77 17 32 32 CD cord-348409-oxjd263z 77 18 , , , cord-348409-oxjd263z 77 19 33 33 CD cord-348409-oxjd263z 77 20 ] ] -RRB- cord-348409-oxjd263z 77 21 . . . cord-348409-oxjd263z 78 1 Inoviruses Inoviruses NNP cord-348409-oxjd263z 78 2 that that WDT cord-348409-oxjd263z 78 3 have have VBP cord-348409-oxjd263z 78 4 been be VBN cord-348409-oxjd263z 78 5 genetically genetically RB cord-348409-oxjd263z 78 6 modified modify VBN cord-348409-oxjd263z 78 7 to to TO cord-348409-oxjd263z 78 8 display display VB cord-348409-oxjd263z 78 9 these these DT cord-348409-oxjd263z 78 10 oligopeptides oligopeptide NNS cord-348409-oxjd263z 78 11 as as IN cord-348409-oxjd263z 78 12 fusion fusion NN cord-348409-oxjd263z 78 13 proteins protein NNS cord-348409-oxjd263z 78 14 on on IN cord-348409-oxjd263z 78 15 their -PRON- PRP$ cord-348409-oxjd263z 78 16 surface surface NN cord-348409-oxjd263z 78 17 are be VBP cord-348409-oxjd263z 78 18 referred refer VBN cord-348409-oxjd263z 78 19 to to IN cord-348409-oxjd263z 78 20 as as IN cord-348409-oxjd263z 78 21 inovirus inovirus NNP cord-348409-oxjd263z 78 22 - - HYPH cord-348409-oxjd263z 78 23 associated associate VBN cord-348409-oxjd263z 78 24 vectors vector NNS cord-348409-oxjd263z 78 25 ( ( -LRB- cord-348409-oxjd263z 78 26 IAVs IAVs NNP cord-348409-oxjd263z 78 27 ) ) -RRB- cord-348409-oxjd263z 78 28 . . . cord-348409-oxjd263z 79 1 Oligopeptides Oligopeptides NNP cord-348409-oxjd263z 79 2 can can MD cord-348409-oxjd263z 79 3 be be VB cord-348409-oxjd263z 79 4 displayed display VBN cord-348409-oxjd263z 79 5 on on IN cord-348409-oxjd263z 79 6 any any DT cord-348409-oxjd263z 79 7 capsid capsid JJ cord-348409-oxjd263z 79 8 protein protein NN cord-348409-oxjd263z 79 9 ( ( -LRB- cord-348409-oxjd263z 79 10 gp3 gp3 NNP cord-348409-oxjd263z 79 11 , , , cord-348409-oxjd263z 79 12 gp6 gp6 NNP cord-348409-oxjd263z 79 13 , , , cord-348409-oxjd263z 79 14 gp7 gp7 NNP cord-348409-oxjd263z 79 15 , , , cord-348409-oxjd263z 79 16 gp8 gp8 NN cord-348409-oxjd263z 79 17 , , , cord-348409-oxjd263z 79 18 and and CC cord-348409-oxjd263z 79 19 gp9 gp9 JJ cord-348409-oxjd263z 79 20 ) ) -RRB- cord-348409-oxjd263z 79 21 following follow VBG cord-348409-oxjd263z 79 22 genetic genetic JJ cord-348409-oxjd263z 79 23 modification modification NN cord-348409-oxjd263z 79 24 . . . cord-348409-oxjd263z 80 1 A a DT cord-348409-oxjd263z 80 2 specific specific JJ cord-348409-oxjd263z 80 3 oligonucleotide oligonucleotide JJ cord-348409-oxjd263z 80 4 sequence sequence NN cord-348409-oxjd263z 80 5 can can MD cord-348409-oxjd263z 80 6 be be VB cord-348409-oxjd263z 80 7 inserted insert VBN cord-348409-oxjd263z 80 8 into into IN cord-348409-oxjd263z 80 9 the the DT cord-348409-oxjd263z 80 10 viral viral JJ cord-348409-oxjd263z 80 11 genome genome NN cord-348409-oxjd263z 80 12 to to TO cord-348409-oxjd263z 80 13 display display VB cord-348409-oxjd263z 80 14 the the DT cord-348409-oxjd263z 80 15 desired desire VBN cord-348409-oxjd263z 80 16 oligopeptide oligopeptide NN cord-348409-oxjd263z 80 17 as as IN cord-348409-oxjd263z 80 18 a a DT cord-348409-oxjd263z 80 19 fusion fusion NN cord-348409-oxjd263z 80 20 with with IN cord-348409-oxjd263z 80 21 capsid capsid NN cord-348409-oxjd263z 80 22 proteins protein NNS cord-348409-oxjd263z 80 23 gp3 gp3 NNP cord-348409-oxjd263z 80 24 , , , cord-348409-oxjd263z 80 25 gp7 gp7 NNP cord-348409-oxjd263z 80 26 , , , cord-348409-oxjd263z 80 27 gp8 gp8 NN cord-348409-oxjd263z 80 28 , , , cord-348409-oxjd263z 80 29 or or CC cord-348409-oxjd263z 80 30 gp9 gp9 JJ cord-348409-oxjd263z 80 31 . . . cord-348409-oxjd263z 81 1 This this DT cord-348409-oxjd263z 81 2 results result VBZ cord-348409-oxjd263z 81 3 in in IN cord-348409-oxjd263z 81 4 the the DT cord-348409-oxjd263z 81 5 oligopeptide oligopeptide NN cord-348409-oxjd263z 81 6 's 's POS cord-348409-oxjd263z 81 7 display display NN cord-348409-oxjd263z 81 8 on on IN cord-348409-oxjd263z 81 9 every every DT cord-348409-oxjd263z 81 10 copy copy NN cord-348409-oxjd263z 81 11 of of IN cord-348409-oxjd263z 81 12 the the DT cord-348409-oxjd263z 81 13 target target NN cord-348409-oxjd263z 81 14 capsid capsid NN cord-348409-oxjd263z 81 15 protein protein NN cord-348409-oxjd263z 81 16 . . . cord-348409-oxjd263z 82 1 However however RB cord-348409-oxjd263z 82 2 , , , cord-348409-oxjd263z 82 3 mosaic mosaic NNP cord-348409-oxjd263z 82 4 inovirus inovirus NNP cord-348409-oxjd263z 82 5 particles particle NNS cord-348409-oxjd263z 82 6 can can MD cord-348409-oxjd263z 82 7 be be VB cord-348409-oxjd263z 82 8 created create VBN cord-348409-oxjd263z 82 9 where where WRB cord-348409-oxjd263z 82 10 the the DT cord-348409-oxjd263z 82 11 specific specific JJ cord-348409-oxjd263z 82 12 capsid capsid NN cord-348409-oxjd263z 82 13 proteins protein NNS cord-348409-oxjd263z 82 14 display display VBP cord-348409-oxjd263z 82 15 a a DT cord-348409-oxjd263z 82 16 mix mix NN cord-348409-oxjd263z 82 17 of of IN cord-348409-oxjd263z 82 18 wild wild JJ cord-348409-oxjd263z 82 19 type type NN cord-348409-oxjd263z 82 20 and and CC cord-348409-oxjd263z 82 21 recombinant recombinant JJ cord-348409-oxjd263z 82 22 proteins protein NNS cord-348409-oxjd263z 82 23 with with IN cord-348409-oxjd263z 82 24 the the DT cord-348409-oxjd263z 82 25 desired desire VBN cord-348409-oxjd263z 82 26 oligopeptide oligopeptide NN cord-348409-oxjd263z 82 27 [ [ -LRB- cord-348409-oxjd263z 82 28 34 34 CD cord-348409-oxjd263z 82 29 ] ] -RRB- cord-348409-oxjd263z 82 30 . . . cord-348409-oxjd263z 83 1 This this DT cord-348409-oxjd263z 83 2 is be VBZ cord-348409-oxjd263z 83 3 done do VBN cord-348409-oxjd263z 83 4 using use VBG cord-348409-oxjd263z 83 5 a a DT cord-348409-oxjd263z 83 6 phagemid phagemid NN cord-348409-oxjd263z 83 7 vector vector NN cord-348409-oxjd263z 83 8 which which WDT cord-348409-oxjd263z 83 9 has have VBZ cord-348409-oxjd263z 83 10 an an DT cord-348409-oxjd263z 83 11 extra extra JJ cord-348409-oxjd263z 83 12 copy copy NN cord-348409-oxjd263z 83 13 of of IN cord-348409-oxjd263z 83 14 a a DT cord-348409-oxjd263z 83 15 capsid capsid NN cord-348409-oxjd263z 83 16 protein protein NN cord-348409-oxjd263z 83 17 fused fuse VBN cord-348409-oxjd263z 83 18 to to IN cord-348409-oxjd263z 83 19 the the DT cord-348409-oxjd263z 83 20 specific specific JJ cord-348409-oxjd263z 83 21 oligonucleotide oligonucleotide NN cord-348409-oxjd263z 83 22 . . . cord-348409-oxjd263z 84 1 A a DT cord-348409-oxjd263z 84 2 host host NN cord-348409-oxjd263z 84 3 exposed expose VBN cord-348409-oxjd263z 84 4 to to IN cord-348409-oxjd263z 84 5 both both CC cord-348409-oxjd263z 84 6 the the DT cord-348409-oxjd263z 84 7 phagemid phagemid NN cord-348409-oxjd263z 84 8 vector vector NN cord-348409-oxjd263z 84 9 and and CC cord-348409-oxjd263z 84 10 a a DT cord-348409-oxjd263z 84 11 wild wild JJ cord-348409-oxjd263z 84 12 type type NN cord-348409-oxjd263z 84 13 capsid capsid NN cord-348409-oxjd263z 84 14 protein protein NN cord-348409-oxjd263z 84 15 from from IN cord-348409-oxjd263z 84 16 a a DT cord-348409-oxjd263z 84 17 deficient deficient JJ cord-348409-oxjd263z 84 18 helper helper NN cord-348409-oxjd263z 84 19 phage phage NN cord-348409-oxjd263z 84 20 produces produce VBZ cord-348409-oxjd263z 84 21 mosaic mosaic NNP cord-348409-oxjd263z 84 22 IAVs iav NNS cord-348409-oxjd263z 84 23 displaying display VBG cord-348409-oxjd263z 84 24 both both DT cord-348409-oxjd263z 84 25 wild wild JJ cord-348409-oxjd263z 84 26 type type NN cord-348409-oxjd263z 84 27 and and CC cord-348409-oxjd263z 84 28 oligopeptide oligopeptide NN cord-348409-oxjd263z 84 29 fused fuse VBN cord-348409-oxjd263z 84 30 capsid capsid NN cord-348409-oxjd263z 84 31 proteins protein NNS cord-348409-oxjd263z 84 32 . . . cord-348409-oxjd263z 85 1 Work work NN cord-348409-oxjd263z 85 2 using use VBG cord-348409-oxjd263z 85 3 the the DT cord-348409-oxjd263z 85 4 capsid capsid JJ cord-348409-oxjd263z 85 5 protein protein NN cord-348409-oxjd263z 85 6 gp6 gp6 NNP cord-348409-oxjd263z 85 7 has have VBZ cord-348409-oxjd263z 85 8 resulted result VBN cord-348409-oxjd263z 85 9 only only RB cord-348409-oxjd263z 85 10 in in IN cord-348409-oxjd263z 85 11 the the DT cord-348409-oxjd263z 85 12 production production NN cord-348409-oxjd263z 85 13 of of IN cord-348409-oxjd263z 85 14 mosaic mosaic NNP cord-348409-oxjd263z 85 15 IAVs iav NNS cord-348409-oxjd263z 85 16 ( ( -LRB- cord-348409-oxjd263z 85 17 for for IN cord-348409-oxjd263z 85 18 reviews review NNS cord-348409-oxjd263z 85 19 see see VBP cord-348409-oxjd263z 85 20 [ [ -LRB- cord-348409-oxjd263z 85 21 35 35 CD cord-348409-oxjd263z 85 22 ] ] -RRB- cord-348409-oxjd263z 86 1 [ [ -LRB- cord-348409-oxjd263z 86 2 36 36 CD cord-348409-oxjd263z 86 3 ] ] -RRB- cord-348409-oxjd263z 87 1 [ [ -LRB- cord-348409-oxjd263z 87 2 37 37 CD cord-348409-oxjd263z 87 3 ] ] -RRB- cord-348409-oxjd263z 87 4 ) ) -RRB- cord-348409-oxjd263z 87 5 while while IN cord-348409-oxjd263z 87 6 both both DT cord-348409-oxjd263z 87 7 mosaic mosaic JJ cord-348409-oxjd263z 87 8 and and CC cord-348409-oxjd263z 87 9 non non JJ cord-348409-oxjd263z 87 10 - - JJ cord-348409-oxjd263z 87 11 mosaic mosaic JJ cord-348409-oxjd263z 87 12 IAVs iav NNS cord-348409-oxjd263z 87 13 have have VBP cord-348409-oxjd263z 87 14 been be VBN cord-348409-oxjd263z 87 15 produced produce VBN cord-348409-oxjd263z 87 16 using use VBG cord-348409-oxjd263z 87 17 gp3 gp3 NNP cord-348409-oxjd263z 87 18 and and CC cord-348409-oxjd263z 87 19 gp8 gp8 NNP cord-348409-oxjd263z 87 20 ( ( -LRB- cord-348409-oxjd263z 87 21 for for IN cord-348409-oxjd263z 87 22 a a DT cord-348409-oxjd263z 87 23 review review NN cord-348409-oxjd263z 87 24 see see VBP cord-348409-oxjd263z 87 25 [ [ -LRB- cord-348409-oxjd263z 87 26 10 10 CD cord-348409-oxjd263z 87 27 ] ] -RRB- cord-348409-oxjd263z 87 28 ) ) -RRB- cord-348409-oxjd263z 88 1 and and CC cord-348409-oxjd263z 88 2 gp7 gp7 NNP cord-348409-oxjd263z 88 3 and and CC cord-348409-oxjd263z 88 4 gp9 gp9 JJ cord-348409-oxjd263z 88 5 ( ( -LRB- cord-348409-oxjd263z 88 6 for for IN cord-348409-oxjd263z 88 7 reviews review NNS cord-348409-oxjd263z 88 8 see see VBP cord-348409-oxjd263z 88 9 [ [ -LRB- cord-348409-oxjd263z 88 10 38 38 CD cord-348409-oxjd263z 88 11 ] ] -RRB- cord-348409-oxjd263z 89 1 [ [ -LRB- cord-348409-oxjd263z 89 2 39 39 CD cord-348409-oxjd263z 89 3 ] ] -RRB- cord-348409-oxjd263z 89 4 [ [ -LRB- cord-348409-oxjd263z 89 5 40 40 CD cord-348409-oxjd263z 89 6 ] ] -RRB- cord-348409-oxjd263z 89 7 ) ) -RRB- cord-348409-oxjd263z 89 8 . . . cord-348409-oxjd263z 90 1 As as IN cord-348409-oxjd263z 90 2 a a DT cord-348409-oxjd263z 90 3 result result NN cord-348409-oxjd263z 90 4 of of IN cord-348409-oxjd263z 90 5 the the DT cord-348409-oxjd263z 90 6 different different JJ cord-348409-oxjd263z 90 7 locations location NNS cord-348409-oxjd263z 90 8 , , , cord-348409-oxjd263z 90 9 structures structure NNS cord-348409-oxjd263z 90 10 , , , cord-348409-oxjd263z 90 11 and and CC cord-348409-oxjd263z 90 12 abundances abundance NNS cord-348409-oxjd263z 90 13 of of IN cord-348409-oxjd263z 90 14 the the DT cord-348409-oxjd263z 90 15 capsid capsid NN cord-348409-oxjd263z 90 16 proteins protein NNS cord-348409-oxjd263z 90 17 in in IN cord-348409-oxjd263z 90 18 IAVs iav NNS cord-348409-oxjd263z 90 19 , , , cord-348409-oxjd263z 90 20 they -PRON- PRP cord-348409-oxjd263z 90 21 have have VBP cord-348409-oxjd263z 90 22 differential differential JJ cord-348409-oxjd263z 90 23 abilities ability NNS cord-348409-oxjd263z 90 24 to to TO cord-348409-oxjd263z 90 25 display display VB cord-348409-oxjd263z 90 26 different different JJ cord-348409-oxjd263z 90 27 oligopeptides oligopeptide NNS cord-348409-oxjd263z 90 28 . . . cord-348409-oxjd263z 91 1 Figure figure NN cord-348409-oxjd263z 91 2 1(b 1(b CD cord-348409-oxjd263z 91 3 ) ) -RRB- cord-348409-oxjd263z 91 4 shows show VBZ cord-348409-oxjd263z 91 5 how how WRB cord-348409-oxjd263z 91 6 each each DT cord-348409-oxjd263z 91 7 of of IN cord-348409-oxjd263z 91 8 the the DT cord-348409-oxjd263z 91 9 five five CD cord-348409-oxjd263z 91 10 capsid capsid NN cord-348409-oxjd263z 91 11 proteins protein NNS cord-348409-oxjd263z 91 12 of of IN cord-348409-oxjd263z 91 13 an an DT cord-348409-oxjd263z 91 14 IAV IAV NNP cord-348409-oxjd263z 91 15 can can MD cord-348409-oxjd263z 91 16 display display VB cord-348409-oxjd263z 91 17 antigens antigen NNS cord-348409-oxjd263z 91 18 , , , cord-348409-oxjd263z 91 19 as as IN cord-348409-oxjd263z 91 20 have have VBP cord-348409-oxjd263z 91 21 been be VBN cord-348409-oxjd263z 91 22 demonstrated demonstrate VBN cord-348409-oxjd263z 91 23 in in IN cord-348409-oxjd263z 91 24 published publish VBN cord-348409-oxjd263z 91 25 literature literature NN cord-348409-oxjd263z 91 26 . . . cord-348409-oxjd263z 92 1 The the DT cord-348409-oxjd263z 92 2 capsid capsid NN cord-348409-oxjd263z 92 3 protein protein NN cord-348409-oxjd263z 92 4 that that WDT cord-348409-oxjd263z 92 5 can can MD cord-348409-oxjd263z 92 6 display display VB cord-348409-oxjd263z 92 7 the the DT cord-348409-oxjd263z 92 8 most most JJS cord-348409-oxjd263z 92 9 copies copy NNS cord-348409-oxjd263z 92 10 of of IN cord-348409-oxjd263z 92 11 the the DT cord-348409-oxjd263z 92 12 desired desire VBN cord-348409-oxjd263z 92 13 oligopeptide oligopeptide NNP cord-348409-oxjd263z 92 14 is be VBZ cord-348409-oxjd263z 92 15 gp8 gp8 JJ cord-348409-oxjd263z 92 16 due due JJ cord-348409-oxjd263z 92 17 to to IN cord-348409-oxjd263z 92 18 the the DT cord-348409-oxjd263z 92 19 large large JJ cord-348409-oxjd263z 92 20 amount amount NN cord-348409-oxjd263z 92 21 of of IN cord-348409-oxjd263z 92 22 gp8 gp8 NN cord-348409-oxjd263z 92 23 in in IN cord-348409-oxjd263z 92 24 each each DT cord-348409-oxjd263z 92 25 inovirus inovirus NNP cord-348409-oxjd263z 92 26 . . . cord-348409-oxjd263z 93 1 A a DT cord-348409-oxjd263z 93 2 non non JJ cord-348409-oxjd263z 93 3 - - JJ cord-348409-oxjd263z 93 4 mosaic mosaic JJ cord-348409-oxjd263z 93 5 IAV IAV NNP cord-348409-oxjd263z 93 6 can can MD cord-348409-oxjd263z 93 7 display display VB cord-348409-oxjd263z 93 8 a a DT cord-348409-oxjd263z 93 9 peptide peptide NN cord-348409-oxjd263z 93 10 on on IN cord-348409-oxjd263z 93 11 each each DT cord-348409-oxjd263z 93 12 of of IN cord-348409-oxjd263z 93 13 the the DT cord-348409-oxjd263z 93 14 approximately approximately RB cord-348409-oxjd263z 93 15 2,700 2,700 CD cord-348409-oxjd263z 93 16 copies copy NNS cord-348409-oxjd263z 93 17 of of IN cord-348409-oxjd263z 93 18 gp8 gp8 NN cord-348409-oxjd263z 93 19 . . . cord-348409-oxjd263z 94 1 However however RB cord-348409-oxjd263z 94 2 , , , cord-348409-oxjd263z 94 3 doing do VBG cord-348409-oxjd263z 94 4 so so RB cord-348409-oxjd263z 94 5 with with IN cord-348409-oxjd263z 94 6 large large JJ cord-348409-oxjd263z 94 7 peptides peptide NNS cord-348409-oxjd263z 94 8 distorts distort VBZ cord-348409-oxjd263z 94 9 the the DT cord-348409-oxjd263z 94 10 virus virus NN cord-348409-oxjd263z 94 11 ; ; : cord-348409-oxjd263z 94 12 only only RB cord-348409-oxjd263z 94 13 peptides peptide NNS cord-348409-oxjd263z 94 14 of of IN cord-348409-oxjd263z 94 15 up up IN cord-348409-oxjd263z 94 16 to to TO cord-348409-oxjd263z 94 17 6 6 CD cord-348409-oxjd263z 94 18 amino amino NN cord-348409-oxjd263z 94 19 acids acid NNS cord-348409-oxjd263z 94 20 can can MD cord-348409-oxjd263z 94 21 be be VB cord-348409-oxjd263z 94 22 displayed display VBN cord-348409-oxjd263z 94 23 in in IN cord-348409-oxjd263z 94 24 such such JJ cord-348409-oxjd263z 94 25 great great JJ cord-348409-oxjd263z 94 26 quantity quantity NN cord-348409-oxjd263z 94 27 without without IN cord-348409-oxjd263z 94 28 affecting affect VBG cord-348409-oxjd263z 94 29 the the DT cord-348409-oxjd263z 94 30 structure structure NN cord-348409-oxjd263z 94 31 of of IN cord-348409-oxjd263z 94 32 the the DT cord-348409-oxjd263z 94 33 inovirus inovirus NNP cord-348409-oxjd263z 94 34 . . . cord-348409-oxjd263z 95 1 However however RB cord-348409-oxjd263z 95 2 , , , cord-348409-oxjd263z 95 3 producing produce VBG cord-348409-oxjd263z 95 4 a a DT cord-348409-oxjd263z 95 5 mosaic mosaic JJ cord-348409-oxjd263z 95 6 IAV iav NN cord-348409-oxjd263z 95 7 with with IN cord-348409-oxjd263z 95 8 oligopeptides oligopeptide NNS cord-348409-oxjd263z 95 9 on on IN cord-348409-oxjd263z 95 10 far far RB cord-348409-oxjd263z 95 11 fewer few JJR cord-348409-oxjd263z 95 12 gp8 gp8 JJ cord-348409-oxjd263z 95 13 units unit NNS cord-348409-oxjd263z 95 14 will will MD cord-348409-oxjd263z 95 15 not not RB cord-348409-oxjd263z 95 16 cause cause VB cord-348409-oxjd263z 95 17 distortion distortion NN cord-348409-oxjd263z 95 18 [ [ -LRB- cord-348409-oxjd263z 95 19 33 33 CD cord-348409-oxjd263z 95 20 ] ] -RRB- cord-348409-oxjd263z 95 21 . . . cord-348409-oxjd263z 96 1 While while IN cord-348409-oxjd263z 96 2 it -PRON- PRP cord-348409-oxjd263z 96 3 is be VBZ cord-348409-oxjd263z 96 4 theoretically theoretically RB cord-348409-oxjd263z 96 5 possible possible JJ cord-348409-oxjd263z 96 6 to to TO cord-348409-oxjd263z 96 7 display display VB cord-348409-oxjd263z 96 8 an an DT cord-348409-oxjd263z 96 9 entire entire JJ cord-348409-oxjd263z 96 10 protein protein NN cord-348409-oxjd263z 96 11 on on IN cord-348409-oxjd263z 96 12 gp3 gp3 NNP cord-348409-oxjd263z 96 13 [ [ -LRB- cord-348409-oxjd263z 96 14 41 41 CD cord-348409-oxjd263z 96 15 ] ] -RRB- cord-348409-oxjd263z 96 16 , , , cord-348409-oxjd263z 96 17 presenting present VBG cord-348409-oxjd263z 96 18 on on IN cord-348409-oxjd263z 96 19 all all DT cord-348409-oxjd263z 96 20 5 5 CD cord-348409-oxjd263z 96 21 copies copy NNS cord-348409-oxjd263z 96 22 per per IN cord-348409-oxjd263z 96 23 virion virion NN cord-348409-oxjd263z 96 24 , , , cord-348409-oxjd263z 96 25 studies study NNS cord-348409-oxjd263z 96 26 have have VBP cord-348409-oxjd263z 96 27 demonstrated demonstrate VBN cord-348409-oxjd263z 96 28 that that IN cord-348409-oxjd263z 96 29 at at RB cord-348409-oxjd263z 96 30 most most RBS cord-348409-oxjd263z 96 31 one one CD cord-348409-oxjd263z 96 32 copy copy NN cord-348409-oxjd263z 96 33 of of IN cord-348409-oxjd263z 96 34 gp3 gp3 NNP cord-348409-oxjd263z 96 35 will will MD cord-348409-oxjd263z 96 36 display display VB cord-348409-oxjd263z 96 37 the the DT cord-348409-oxjd263z 96 38 desired desire VBN cord-348409-oxjd263z 96 39 protein protein NN cord-348409-oxjd263z 96 40 [ [ -LRB- cord-348409-oxjd263z 96 41 34 34 CD cord-348409-oxjd263z 96 42 ] ] -RRB- cord-348409-oxjd263z 96 43 . . . cord-348409-oxjd263z 97 1 The the DT cord-348409-oxjd263z 97 2 ability ability NN cord-348409-oxjd263z 97 3 of of IN cord-348409-oxjd263z 97 4 IAVs iav NNS cord-348409-oxjd263z 97 5 to to TO cord-348409-oxjd263z 97 6 display display VB cord-348409-oxjd263z 97 7 different different JJ cord-348409-oxjd263z 97 8 random random JJ cord-348409-oxjd263z 97 9 oligopeptides oligopeptide NNS cord-348409-oxjd263z 97 10 on on IN cord-348409-oxjd263z 97 11 their -PRON- PRP$ cord-348409-oxjd263z 97 12 surface surface NN cord-348409-oxjd263z 97 13 has have VBZ cord-348409-oxjd263z 97 14 many many JJ cord-348409-oxjd263z 97 15 applications application NNS cord-348409-oxjd263z 97 16 , , , cord-348409-oxjd263z 97 17 and and CC cord-348409-oxjd263z 97 18 is be VBZ cord-348409-oxjd263z 97 19 especially especially RB cord-348409-oxjd263z 97 20 useful useful JJ cord-348409-oxjd263z 97 21 in in IN cord-348409-oxjd263z 97 22 for for IN cord-348409-oxjd263z 97 23 vaccine vaccine NN cord-348409-oxjd263z 97 24 development development NN cord-348409-oxjd263z 97 25 . . . cord-348409-oxjd263z 98 1 The the DT cord-348409-oxjd263z 98 2 creation creation NN cord-348409-oxjd263z 98 3 of of IN cord-348409-oxjd263z 98 4 Random Random NNP cord-348409-oxjd263z 98 5 Peptide Peptide NNP cord-348409-oxjd263z 98 6 Libraries Libraries NNPS cord-348409-oxjd263z 98 7 ( ( -LRB- cord-348409-oxjd263z 98 8 RPL RPL NNP cord-348409-oxjd263z 98 9 ) ) -RRB- cord-348409-oxjd263z 98 10 , , , cord-348409-oxjd263z 98 11 where where WRB cord-348409-oxjd263z 98 12 random random JJ cord-348409-oxjd263z 98 13 oligopeptides oligopeptide NNS cord-348409-oxjd263z 98 14 are be VBP cord-348409-oxjd263z 98 15 fused fuse VBN cord-348409-oxjd263z 98 16 to to IN cord-348409-oxjd263z 98 17 major major JJ cord-348409-oxjd263z 98 18 capsid capsid NN cord-348409-oxjd263z 98 19 proteins protein NNS cord-348409-oxjd263z 98 20 ( ( -LRB- cord-348409-oxjd263z 98 21 gp3 gp3 NNP cord-348409-oxjd263z 98 22 or or CC cord-348409-oxjd263z 98 23 gp8 gp8 NNP cord-348409-oxjd263z 98 24 ) ) -RRB- cord-348409-oxjd263z 98 25 and and CC cord-348409-oxjd263z 98 26 displayed display VBN cord-348409-oxjd263z 98 27 on on IN cord-348409-oxjd263z 98 28 individual individual JJ cord-348409-oxjd263z 98 29 inovirus inovirus NNP cord-348409-oxjd263z 98 30 clones clone NNS cord-348409-oxjd263z 98 31 creating create VBG cord-348409-oxjd263z 98 32 a a DT cord-348409-oxjd263z 98 33 random random JJ cord-348409-oxjd263z 98 34 variety variety NN cord-348409-oxjd263z 98 35 of of IN cord-348409-oxjd263z 98 36 IAVs iav NNS cord-348409-oxjd263z 98 37 which which WDT cord-348409-oxjd263z 98 38 can can MD cord-348409-oxjd263z 98 39 be be VB cord-348409-oxjd263z 98 40 used use VBN cord-348409-oxjd263z 98 41 for for IN cord-348409-oxjd263z 98 42 vaccine vaccine NN cord-348409-oxjd263z 98 43 design design NN cord-348409-oxjd263z 98 44 via via IN cord-348409-oxjd263z 98 45 epitope epitope NN cord-348409-oxjd263z 98 46 mapping mapping NN cord-348409-oxjd263z 98 47 using use VBG cord-348409-oxjd263z 98 48 monoclonal monoclonal JJ cord-348409-oxjd263z 98 49 or or CC cord-348409-oxjd263z 98 50 polyclonal polyclonal JJ cord-348409-oxjd263z 98 51 antibodies antibody NNS cord-348409-oxjd263z 98 52 . . . cord-348409-oxjd263z 99 1 These these DT cord-348409-oxjd263z 99 2 random random JJ cord-348409-oxjd263z 99 3 IAVs iav NNS cord-348409-oxjd263z 99 4 , , , cord-348409-oxjd263z 99 5 whose whose WP$ cord-348409-oxjd263z 99 6 oligopeptide oligopeptide JJ cord-348409-oxjd263z 99 7 diversity diversity NN cord-348409-oxjd263z 99 8 increases increase NNS cord-348409-oxjd263z 99 9 with with IN cord-348409-oxjd263z 99 10 increased increase VBN cord-348409-oxjd263z 99 11 peptide peptide JJ cord-348409-oxjd263z 99 12 length length NN cord-348409-oxjd263z 99 13 , , , cord-348409-oxjd263z 99 14 can can MD cord-348409-oxjd263z 99 15 be be VB cord-348409-oxjd263z 99 16 used use VBN cord-348409-oxjd263z 99 17 to to TO cord-348409-oxjd263z 99 18 identify identify VB cord-348409-oxjd263z 99 19 the the DT cord-348409-oxjd263z 99 20 epitopes epitope NNS cord-348409-oxjd263z 99 21 of of IN cord-348409-oxjd263z 99 22 specific specific JJ cord-348409-oxjd263z 99 23 antibodies antibody NNS cord-348409-oxjd263z 99 24 through through IN cord-348409-oxjd263z 99 25 a a DT cord-348409-oxjd263z 99 26 process process NN cord-348409-oxjd263z 99 27 called call VBN cord-348409-oxjd263z 99 28 biopanning biopanne VBG cord-348409-oxjd263z 99 29 . . . cord-348409-oxjd263z 100 1 This this DT cord-348409-oxjd263z 100 2 allows allow VBZ cord-348409-oxjd263z 100 3 for for IN cord-348409-oxjd263z 100 4 the the DT cord-348409-oxjd263z 100 5 isolation isolation NN cord-348409-oxjd263z 100 6 of of IN cord-348409-oxjd263z 100 7 IAVs iav NNS cord-348409-oxjd263z 100 8 displaying display VBG cord-348409-oxjd263z 100 9 mimotopes mimotopes NNP cord-348409-oxjd263z 100 10 which which WDT cord-348409-oxjd263z 100 11 mimic mimic VBP cord-348409-oxjd263z 100 12 the the DT cord-348409-oxjd263z 100 13 antibody antibody NN cord-348409-oxjd263z 100 14 discontinuous discontinuous JJ cord-348409-oxjd263z 100 15 target target NN cord-348409-oxjd263z 100 16 epitope epitope NN cord-348409-oxjd263z 100 17 . . . cord-348409-oxjd263z 101 1 By by IN cord-348409-oxjd263z 101 2 isolating isolate VBG cord-348409-oxjd263z 101 3 the the DT cord-348409-oxjd263z 101 4 recombinant recombinant JJ cord-348409-oxjd263z 101 5 inoviruses inoviruses NNP cord-348409-oxjd263z 101 6 bearing bearing NN cord-348409-oxjd263z 101 7 mimotopes mimotopes NNP cord-348409-oxjd263z 101 8 , , , cord-348409-oxjd263z 101 9 the the DT cord-348409-oxjd263z 101 10 DNA dna NN cord-348409-oxjd263z 101 11 and and CC cord-348409-oxjd263z 101 12 amino amino NN cord-348409-oxjd263z 101 13 acid acid NN cord-348409-oxjd263z 101 14 sequence sequence NN cord-348409-oxjd263z 101 15 of of IN cord-348409-oxjd263z 101 16 the the DT cord-348409-oxjd263z 101 17 oligopeptides oligopeptide NNS cord-348409-oxjd263z 101 18 of of IN cord-348409-oxjd263z 101 19 interest interest NN cord-348409-oxjd263z 101 20 can can MD cord-348409-oxjd263z 101 21 be be VB cord-348409-oxjd263z 101 22 determined determine VBN cord-348409-oxjd263z 101 23 . . . cord-348409-oxjd263z 102 1 Through through IN cord-348409-oxjd263z 102 2 this this DT cord-348409-oxjd263z 102 3 breakthrough breakthrough NN cord-348409-oxjd263z 102 4 technology technology NN cord-348409-oxjd263z 102 5 which which WDT cord-348409-oxjd263z 102 6 was be VBD cord-348409-oxjd263z 102 7 the the DT cord-348409-oxjd263z 102 8 subject subject JJ cord-348409-oxjd263z 102 9 matter matter NN cord-348409-oxjd263z 102 10 of of IN cord-348409-oxjd263z 102 11 the the DT cord-348409-oxjd263z 102 12 Nobel Nobel NNP cord-348409-oxjd263z 102 13 Prize Prize NNP cord-348409-oxjd263z 102 14 in in IN cord-348409-oxjd263z 102 15 Chemistry Chemistry NNP cord-348409-oxjd263z 102 16 2018 2018 CD cord-348409-oxjd263z 102 17 ( ( -LRB- cord-348409-oxjd263z 102 18 see see VB cord-348409-oxjd263z 102 19 ' ' '' cord-348409-oxjd263z 102 20 Expert Expert NNP cord-348409-oxjd263z 102 21 Commentary Commentary NNP cord-348409-oxjd263z 102 22 ' ' '' cord-348409-oxjd263z 102 23 below below RB cord-348409-oxjd263z 102 24 ) ) -RRB- cord-348409-oxjd263z 102 25 , , , cord-348409-oxjd263z 102 26 inovriuses inovriuses NNP cord-348409-oxjd263z 102 27 displaying display VBG cord-348409-oxjd263z 102 28 oligopeptides oligopeptide NNS cord-348409-oxjd263z 102 29 mimicking mimic VBG cord-348409-oxjd263z 102 30 antigens antigen NNS cord-348409-oxjd263z 102 31 ( ( -LRB- cord-348409-oxjd263z 102 32 or or CC cord-348409-oxjd263z 102 33 specific specific JJ cord-348409-oxjd263z 102 34 epitopes epitope NNS cord-348409-oxjd263z 102 35 of of IN cord-348409-oxjd263z 102 36 an an DT cord-348409-oxjd263z 102 37 antigen antigen NN cord-348409-oxjd263z 102 38 ) ) -RRB- cord-348409-oxjd263z 102 39 can can MD cord-348409-oxjd263z 102 40 be be VB cord-348409-oxjd263z 102 41 used use VBN cord-348409-oxjd263z 102 42 to to TO cord-348409-oxjd263z 102 43 vaccinate vaccinate VB cord-348409-oxjd263z 102 44 hosts host NNS cord-348409-oxjd263z 102 45 thus thus RB cord-348409-oxjd263z 102 46 inducing induce VBG cord-348409-oxjd263z 102 47 the the DT cord-348409-oxjd263z 102 48 desired desire VBN cord-348409-oxjd263z 102 49 antibody antibody NN cord-348409-oxjd263z 102 50 production production NN cord-348409-oxjd263z 102 51 . . . cord-348409-oxjd263z 103 1 Vaccines vaccine NNS cord-348409-oxjd263z 103 2 of of IN cord-348409-oxjd263z 103 3 this this DT cord-348409-oxjd263z 103 4 sort sort NN cord-348409-oxjd263z 103 5 have have VBP cord-348409-oxjd263z 103 6 been be VBN cord-348409-oxjd263z 103 7 developed develop VBN cord-348409-oxjd263z 103 8 in in IN cord-348409-oxjd263z 103 9 a a DT cord-348409-oxjd263z 103 10 variety variety NN cord-348409-oxjd263z 103 11 of of IN cord-348409-oxjd263z 103 12 organisms organism NNS cord-348409-oxjd263z 103 13 against against IN cord-348409-oxjd263z 103 14 many many JJ cord-348409-oxjd263z 103 15 different different JJ cord-348409-oxjd263z 103 16 diseases disease NNS cord-348409-oxjd263z 103 17 ( ( -LRB- cord-348409-oxjd263z 103 18 See see VB cord-348409-oxjd263z 103 19 tables table NNS cord-348409-oxjd263z 103 20 1 1 CD cord-348409-oxjd263z 103 21 and and CC cord-348409-oxjd263z 103 22 2 2 CD cord-348409-oxjd263z 103 23 in in IN cord-348409-oxjd263z 103 24 [ [ -LRB- cord-348409-oxjd263z 103 25 31 31 CD cord-348409-oxjd263z 103 26 ] ] -RRB- cord-348409-oxjd263z 103 27 for for IN cord-348409-oxjd263z 103 28 a a DT cord-348409-oxjd263z 103 29 list list NN cord-348409-oxjd263z 103 30 of of IN cord-348409-oxjd263z 103 31 inovirus inovirus NNP cord-348409-oxjd263z 103 32 - - HYPH cord-348409-oxjd263z 103 33 based base VBN cord-348409-oxjd263z 103 34 vaccines vaccine NNS cord-348409-oxjd263z 103 35 ) ) -RRB- cord-348409-oxjd263z 103 36 , , , cord-348409-oxjd263z 103 37 as as IN cord-348409-oxjd263z 103 38 the the DT cord-348409-oxjd263z 103 39 introduction introduction NN cord-348409-oxjd263z 103 40 of of IN cord-348409-oxjd263z 103 41 the the DT cord-348409-oxjd263z 103 42 inoviruses inoviruse NNS cord-348409-oxjd263z 103 43 can can MD cord-348409-oxjd263z 103 44 induce induce VB cord-348409-oxjd263z 103 45 the the DT cord-348409-oxjd263z 103 46 production production NN cord-348409-oxjd263z 103 47 of of IN cord-348409-oxjd263z 103 48 specific specific JJ cord-348409-oxjd263z 103 49 antibodies antibody NNS cord-348409-oxjd263z 103 50 . . . cord-348409-oxjd263z 104 1 While while IN cord-348409-oxjd263z 104 2 there there EX cord-348409-oxjd263z 104 3 have have VBP cord-348409-oxjd263z 104 4 already already RB cord-348409-oxjd263z 104 5 been be VBN cord-348409-oxjd263z 104 6 various various JJ cord-348409-oxjd263z 104 7 successes success NNS cord-348409-oxjd263z 104 8 , , , cord-348409-oxjd263z 104 9 this this DT cord-348409-oxjd263z 104 10 method method NN cord-348409-oxjd263z 104 11 can can MD cord-348409-oxjd263z 104 12 potentially potentially RB cord-348409-oxjd263z 104 13 open open VB cord-348409-oxjd263z 104 14 the the DT cord-348409-oxjd263z 104 15 door door NN cord-348409-oxjd263z 104 16 to to IN cord-348409-oxjd263z 104 17 the the DT cord-348409-oxjd263z 104 18 development development NN cord-348409-oxjd263z 104 19 of of IN cord-348409-oxjd263z 104 20 many many JJ cord-348409-oxjd263z 104 21 novel novel JJ cord-348409-oxjd263z 104 22 vaccines vaccine NNS cord-348409-oxjd263z 104 23 and and CC cord-348409-oxjd263z 104 24 vaccine vaccine NN cord-348409-oxjd263z 104 25 methodologies methodology NNS cord-348409-oxjd263z 104 26 . . . cord-348409-oxjd263z 105 1 IAVs iav NNS cord-348409-oxjd263z 105 2 have have VBP cord-348409-oxjd263z 105 3 been be VBN cord-348409-oxjd263z 105 4 successfully successfully RB cord-348409-oxjd263z 105 5 used use VBN cord-348409-oxjd263z 105 6 as as IN cord-348409-oxjd263z 105 7 vaccine vaccine NN cord-348409-oxjd263z 105 8 carriers carrier NNS cord-348409-oxjd263z 105 9 for for IN cord-348409-oxjd263z 105 10 a a DT cord-348409-oxjd263z 105 11 variety variety NN cord-348409-oxjd263z 105 12 of of IN cord-348409-oxjd263z 105 13 species specie NNS cord-348409-oxjd263z 105 14 and and CC cord-348409-oxjd263z 105 15 diseases disease NNS cord-348409-oxjd263z 105 16 across across IN cord-348409-oxjd263z 105 17 a a DT cord-348409-oxjd263z 105 18 range range NN cord-348409-oxjd263z 105 19 of of IN cord-348409-oxjd263z 105 20 vaccine vaccine NN cord-348409-oxjd263z 105 21 studies study NNS cord-348409-oxjd263z 105 22 ( ( -LRB- cord-348409-oxjd263z 105 23 as as IN cord-348409-oxjd263z 105 24 shown show VBN cord-348409-oxjd263z 105 25 in in IN cord-348409-oxjd263z 105 26 [ [ -LRB- cord-348409-oxjd263z 105 27 31 31 CD cord-348409-oxjd263z 105 28 ] ] -RRB- cord-348409-oxjd263z 105 29 ) ) -RRB- cord-348409-oxjd263z 105 30 . . . cord-348409-oxjd263z 106 1 These these DT cord-348409-oxjd263z 106 2 vaccines vaccine NNS cord-348409-oxjd263z 106 3 have have VBP cord-348409-oxjd263z 106 4 been be VBN cord-348409-oxjd263z 106 5 effective effective JJ cord-348409-oxjd263z 106 6 against against IN cord-348409-oxjd263z 106 7 infections infection NNS cord-348409-oxjd263z 106 8 agents agent NNS cord-348409-oxjd263z 106 9 such such JJ cord-348409-oxjd263z 106 10 as as IN cord-348409-oxjd263z 106 11 viral viral JJ cord-348409-oxjd263z 106 12 , , , cord-348409-oxjd263z 106 13 protozoan protozoan NN cord-348409-oxjd263z 106 14 , , , cord-348409-oxjd263z 106 15 and and CC cord-348409-oxjd263z 106 16 worm worm NN cord-348409-oxjd263z 106 17 parasites parasite NNS cord-348409-oxjd263z 106 18 as as RB cord-348409-oxjd263z 106 19 well well RB cord-348409-oxjd263z 106 20 as as IN cord-348409-oxjd263z 106 21 non non JJ cord-348409-oxjd263z 106 22 - - JJ cord-348409-oxjd263z 106 23 infectious infectious JJ cord-348409-oxjd263z 106 24 diseases disease NNS cord-348409-oxjd263z 106 25 including include VBG cord-348409-oxjd263z 106 26 Alzheimer Alzheimer NNP cord-348409-oxjd263z 106 27 's 's POS cord-348409-oxjd263z 106 28 and and CC cord-348409-oxjd263z 106 29 a a DT cord-348409-oxjd263z 106 30 variety variety NN cord-348409-oxjd263z 106 31 of of IN cord-348409-oxjd263z 106 32 cancers cancer NNS cord-348409-oxjd263z 106 33 . . . cord-348409-oxjd263z 107 1 Inovirus Inovirus NNP cord-348409-oxjd263z 107 2 display display NN cord-348409-oxjd263z 107 3 technology technology NN cord-348409-oxjd263z 107 4 has have VBZ cord-348409-oxjd263z 107 5 been be VBN cord-348409-oxjd263z 107 6 used use VBN cord-348409-oxjd263z 107 7 in in IN cord-348409-oxjd263z 107 8 two two CD cord-348409-oxjd263z 107 9 different different JJ cord-348409-oxjd263z 107 10 ways way NNS cord-348409-oxjd263z 107 11 to to TO cord-348409-oxjd263z 107 12 develop develop VB cord-348409-oxjd263z 107 13 vaccines vaccine NNS cord-348409-oxjd263z 107 14 . . . cord-348409-oxjd263z 108 1 The the DT cord-348409-oxjd263z 108 2 first first JJ cord-348409-oxjd263z 108 3 method method NN cord-348409-oxjd263z 108 4 employs employ VBZ cord-348409-oxjd263z 108 5 inovirus inovirus JJ cord-348409-oxjd263z 108 6 display display NN cord-348409-oxjd263z 108 7 technology technology NN cord-348409-oxjd263z 108 8 to to IN cord-348409-oxjd263z 108 9 screen screen NN cord-348409-oxjd263z 108 10 RPLs rpl NNS cord-348409-oxjd263z 108 11 with with IN cord-348409-oxjd263z 108 12 monoclonal monoclonal JJ cord-348409-oxjd263z 108 13 antibodies antibody NNS cord-348409-oxjd263z 108 14 to to TO cord-348409-oxjd263z 108 15 determine determine VB cord-348409-oxjd263z 108 16 which which WDT cord-348409-oxjd263z 108 17 peptides peptide NNS cord-348409-oxjd263z 108 18 can can MD cord-348409-oxjd263z 108 19 be be VB cord-348409-oxjd263z 108 20 used use VBN cord-348409-oxjd263z 108 21 . . . cord-348409-oxjd263z 109 1 These these DT cord-348409-oxjd263z 109 2 immunogenic immunogenic JJ cord-348409-oxjd263z 109 3 peptides peptide NNS cord-348409-oxjd263z 109 4 are be VBP cord-348409-oxjd263z 109 5 used use VBN cord-348409-oxjd263z 109 6 as as IN cord-348409-oxjd263z 109 7 vaccines vaccine NNS cord-348409-oxjd263z 109 8 either either CC cord-348409-oxjd263z 109 9 with with IN cord-348409-oxjd263z 109 10 carrier carrier NN cord-348409-oxjd263z 109 11 proteins protein NNS cord-348409-oxjd263z 109 12 or or CC cord-348409-oxjd263z 109 13 in in IN cord-348409-oxjd263z 109 14 their -PRON- PRP$ cord-348409-oxjd263z 109 15 soluble soluble JJ cord-348409-oxjd263z 109 16 forms form NNS cord-348409-oxjd263z 109 17 to to TO cord-348409-oxjd263z 109 18 elicit elicit VB cord-348409-oxjd263z 109 19 an an DT cord-348409-oxjd263z 109 20 immune immune JJ cord-348409-oxjd263z 109 21 response response NN cord-348409-oxjd263z 109 22 [ [ -LRB- cord-348409-oxjd263z 109 23 42 42 CD cord-348409-oxjd263z 109 24 ] ] -RRB- cord-348409-oxjd263z 109 25 [ [ -LRB- cord-348409-oxjd263z 109 26 43 43 CD cord-348409-oxjd263z 109 27 ] ] -RRB- cord-348409-oxjd263z 109 28 [ [ -LRB- cord-348409-oxjd263z 109 29 44 44 CD cord-348409-oxjd263z 109 30 ] ] -RRB- cord-348409-oxjd263z 109 31 [ [ -LRB- cord-348409-oxjd263z 109 32 45 45 CD cord-348409-oxjd263z 109 33 ] ] -RRB- cord-348409-oxjd263z 110 1 [ [ -LRB- cord-348409-oxjd263z 110 2 46 46 CD cord-348409-oxjd263z 110 3 ] ] -RRB- cord-348409-oxjd263z 111 1 [ [ -LRB- cord-348409-oxjd263z 111 2 47 47 CD cord-348409-oxjd263z 111 3 ] ] -RRB- cord-348409-oxjd263z 112 1 [ [ -LRB- cord-348409-oxjd263z 112 2 48 48 CD cord-348409-oxjd263z 112 3 ] ] -RRB- cord-348409-oxjd263z 113 1 [ [ -LRB- cord-348409-oxjd263z 113 2 49 49 CD cord-348409-oxjd263z 113 3 ] ] -RRB- cord-348409-oxjd263z 113 4 [ [ -LRB- cord-348409-oxjd263z 113 5 50 50 CD cord-348409-oxjd263z 113 6 ] ] -RRB- cord-348409-oxjd263z 113 7 [ [ -LRB- cord-348409-oxjd263z 113 8 51 51 CD cord-348409-oxjd263z 113 9 ] ] -RRB- cord-348409-oxjd263z 114 1 [ [ -LRB- cord-348409-oxjd263z 114 2 52 52 CD cord-348409-oxjd263z 114 3 ] ] -RRB- cord-348409-oxjd263z 115 1 [ [ -LRB- cord-348409-oxjd263z 115 2 53 53 CD cord-348409-oxjd263z 115 3 ] ] -RRB- cord-348409-oxjd263z 116 1 [ [ -LRB- cord-348409-oxjd263z 116 2 54 54 CD cord-348409-oxjd263z 116 3 ] ] -RRB- cord-348409-oxjd263z 117 1 [ [ -LRB- cord-348409-oxjd263z 117 2 55 55 CD cord-348409-oxjd263z 117 3 ] ] -RRB- cord-348409-oxjd263z 117 4 . . . cord-348409-oxjd263z 118 1 The the DT cord-348409-oxjd263z 118 2 second second JJ cord-348409-oxjd263z 118 3 method method NN cord-348409-oxjd263z 118 4 not not RB cord-348409-oxjd263z 118 5 only only RB cord-348409-oxjd263z 118 6 employs employ VBZ cord-348409-oxjd263z 118 7 inoviruses inoviruse NNS cord-348409-oxjd263z 118 8 for for IN cord-348409-oxjd263z 118 9 epitope epitope NN cord-348409-oxjd263z 118 10 mapping mapping NN cord-348409-oxjd263z 118 11 , , , cord-348409-oxjd263z 118 12 but but CC cord-348409-oxjd263z 118 13 also also RB cord-348409-oxjd263z 118 14 utilizes utilize VBZ cord-348409-oxjd263z 118 15 inoviruses inoviruse NNS cord-348409-oxjd263z 118 16 to to TO cord-348409-oxjd263z 118 17 serve serve VB cord-348409-oxjd263z 118 18 as as IN cord-348409-oxjd263z 118 19 the the DT cord-348409-oxjd263z 118 20 carrier carrier NN cord-348409-oxjd263z 118 21 for for IN cord-348409-oxjd263z 118 22 the the DT cord-348409-oxjd263z 118 23 isolated isolated JJ cord-348409-oxjd263z 118 24 immunogenic immunogenic JJ cord-348409-oxjd263z 118 25 peptide peptide NN cord-348409-oxjd263z 118 26 . . . cord-348409-oxjd263z 119 1 Directly directly RB cord-348409-oxjd263z 119 2 using use VBG cord-348409-oxjd263z 119 3 IAVs iav NNS cord-348409-oxjd263z 119 4 to to TO cord-348409-oxjd263z 119 5 present present VB cord-348409-oxjd263z 119 6 the the DT cord-348409-oxjd263z 119 7 peptide peptide NN cord-348409-oxjd263z 119 8 has have VBZ cord-348409-oxjd263z 119 9 been be VBN cord-348409-oxjd263z 119 10 more more RBR cord-348409-oxjd263z 119 11 consistently consistently RB cord-348409-oxjd263z 119 12 successful successful JJ cord-348409-oxjd263z 119 13 in in IN cord-348409-oxjd263z 119 14 producing produce VBG cord-348409-oxjd263z 119 15 the the DT cord-348409-oxjd263z 119 16 production production NN cord-348409-oxjd263z 119 17 of of IN cord-348409-oxjd263z 119 18 the the DT cord-348409-oxjd263z 119 19 proper proper JJ cord-348409-oxjd263z 119 20 antibody antibody NN cord-348409-oxjd263z 119 21 than than IN cord-348409-oxjd263z 119 22 the the DT cord-348409-oxjd263z 119 23 introduction introduction NN cord-348409-oxjd263z 119 24 of of IN cord-348409-oxjd263z 119 25 soluble soluble JJ cord-348409-oxjd263z 119 26 peptides peptide NNS cord-348409-oxjd263z 119 27 . . . cord-348409-oxjd263z 120 1 Inovirus Inovirus NNP cord-348409-oxjd263z 120 2 - - HYPH cord-348409-oxjd263z 120 3 bound bind VBN cord-348409-oxjd263z 120 4 peptides peptide NNS cord-348409-oxjd263z 120 5 ( ( -LRB- cord-348409-oxjd263z 120 6 on on IN cord-348409-oxjd263z 120 7 IAVs iav NNS cord-348409-oxjd263z 120 8 ) ) -RRB- cord-348409-oxjd263z 120 9 consistently consistently RB cord-348409-oxjd263z 120 10 retain retain VBP cord-348409-oxjd263z 120 11 their -PRON- PRP$ cord-348409-oxjd263z 120 12 3D 3d JJ cord-348409-oxjd263z 120 13 structure structure NN cord-348409-oxjd263z 120 14 and and CC cord-348409-oxjd263z 120 15 are be VBP cord-348409-oxjd263z 120 16 more more RBR cord-348409-oxjd263z 120 17 stable stable JJ cord-348409-oxjd263z 120 18 than than IN cord-348409-oxjd263z 120 19 soluble soluble JJ cord-348409-oxjd263z 120 20 peptides peptide NNS cord-348409-oxjd263z 120 21 , , , cord-348409-oxjd263z 120 22 which which WDT cord-348409-oxjd263z 120 23 do do VBP cord-348409-oxjd263z 120 24 not not RB cord-348409-oxjd263z 120 25 always always RB cord-348409-oxjd263z 120 26 reflect reflect VB cord-348409-oxjd263z 120 27 the the DT cord-348409-oxjd263z 120 28 desired desire VBN cord-348409-oxjd263z 120 29 antigen antigen NN cord-348409-oxjd263z 120 30 epitope epitope NN cord-348409-oxjd263z 120 31 [ [ -LRB- cord-348409-oxjd263z 120 32 84 84 CD cord-348409-oxjd263z 120 33 ] ] -RRB- cord-348409-oxjd263z 120 34 . . . cord-348409-oxjd263z 121 1 IAVs iav NNS cord-348409-oxjd263z 121 2 are be VBP cord-348409-oxjd263z 121 3 structurally structurally RB cord-348409-oxjd263z 121 4 simple simple JJ cord-348409-oxjd263z 121 5 , , , cord-348409-oxjd263z 121 6 which which WDT cord-348409-oxjd263z 121 7 allows allow VBZ cord-348409-oxjd263z 121 8 the the DT cord-348409-oxjd263z 121 9 immune immune JJ cord-348409-oxjd263z 121 10 system system NN cord-348409-oxjd263z 121 11 to to TO cord-348409-oxjd263z 121 12 respond respond VB cord-348409-oxjd263z 121 13 to to IN cord-348409-oxjd263z 121 14 the the DT cord-348409-oxjd263z 121 15 fused fuse VBN cord-348409-oxjd263z 121 16 peptides peptide NNS cord-348409-oxjd263z 121 17 rather rather RB cord-348409-oxjd263z 121 18 than than IN cord-348409-oxjd263z 121 19 the the DT cord-348409-oxjd263z 121 20 viral viral JJ cord-348409-oxjd263z 121 21 coat coat NN cord-348409-oxjd263z 121 22 . . . cord-348409-oxjd263z 122 1 Combined combine VBN cord-348409-oxjd263z 122 2 with with IN cord-348409-oxjd263z 122 3 ability ability NN cord-348409-oxjd263z 122 4 to to TO cord-348409-oxjd263z 122 5 display display VB cord-348409-oxjd263z 122 6 many many JJ cord-348409-oxjd263z 122 7 copies copy NNS cord-348409-oxjd263z 122 8 of of IN cord-348409-oxjd263z 122 9 the the DT cord-348409-oxjd263z 122 10 desired desire VBN cord-348409-oxjd263z 122 11 peptide peptide NN cord-348409-oxjd263z 122 12 , , , cord-348409-oxjd263z 122 13 IAVs iav NNS cord-348409-oxjd263z 122 14 are be VBP cord-348409-oxjd263z 122 15 highly highly RB cord-348409-oxjd263z 122 16 immunogenic immunogenic JJ cord-348409-oxjd263z 122 17 , , , cord-348409-oxjd263z 122 18 creating create VBG cord-348409-oxjd263z 122 19 effective effective JJ cord-348409-oxjd263z 122 20 vaccines vaccine NNS cord-348409-oxjd263z 122 21 [ [ -LRB- cord-348409-oxjd263z 122 22 85 85 CD cord-348409-oxjd263z 122 23 ] ] -RRB- cord-348409-oxjd263z 122 24 . . . cord-348409-oxjd263z 123 1 Because because IN cord-348409-oxjd263z 123 2 the the DT cord-348409-oxjd263z 123 3 inoviruses inoviruse NNS cord-348409-oxjd263z 123 4 replicate replicate VBP cord-348409-oxjd263z 123 5 in in IN cord-348409-oxjd263z 123 6 E. E. NNP cord-348409-oxjd263z 123 7 coli coli NNS cord-348409-oxjd263z 123 8 cultures culture NNS cord-348409-oxjd263z 123 9 , , , cord-348409-oxjd263z 123 10 the the DT cord-348409-oxjd263z 123 11 production production NN cord-348409-oxjd263z 123 12 of of IN cord-348409-oxjd263z 123 13 large large JJ cord-348409-oxjd263z 123 14 numbers number NNS cord-348409-oxjd263z 123 15 of of IN cord-348409-oxjd263z 123 16 vaccines vaccine NNS cord-348409-oxjd263z 123 17 is be VBZ cord-348409-oxjd263z 123 18 cost cost NN cord-348409-oxjd263z 123 19 - - HYPH cord-348409-oxjd263z 123 20 efficient efficient JJ cord-348409-oxjd263z 123 21 . . . cord-348409-oxjd263z 124 1 IAV IAV NNP cord-348409-oxjd263z 124 2 's 's POS cord-348409-oxjd263z 124 3 structural structural JJ cord-348409-oxjd263z 124 4 simplicity simplicity NN cord-348409-oxjd263z 124 5 , , , cord-348409-oxjd263z 124 6 high high JJ cord-348409-oxjd263z 124 7 immunogenicity immunogenicity NN cord-348409-oxjd263z 124 8 , , , cord-348409-oxjd263z 124 9 and and CC cord-348409-oxjd263z 124 10 economical economical JJ cord-348409-oxjd263z 124 11 production production NN cord-348409-oxjd263z 124 12 make make VBP cord-348409-oxjd263z 124 13 them -PRON- PRP cord-348409-oxjd263z 124 14 an an DT cord-348409-oxjd263z 124 15 efficient efficient JJ cord-348409-oxjd263z 124 16 and and CC cord-348409-oxjd263z 124 17 attainable attainable JJ cord-348409-oxjd263z 124 18 system system NN cord-348409-oxjd263z 124 19 for for IN cord-348409-oxjd263z 124 20 creating create VBG cord-348409-oxjd263z 124 21 a a DT cord-348409-oxjd263z 124 22 variety variety NN cord-348409-oxjd263z 124 23 of of IN cord-348409-oxjd263z 124 24 effective effective JJ cord-348409-oxjd263z 124 25 vaccines vaccine NNS cord-348409-oxjd263z 124 26 . . . cord-348409-oxjd263z 125 1 Much much JJ cord-348409-oxjd263z 125 2 of of IN cord-348409-oxjd263z 125 3 the the DT cord-348409-oxjd263z 125 4 research research NN cord-348409-oxjd263z 125 5 involving involve VBG cord-348409-oxjd263z 125 6 inovirus inovirus NNP cord-348409-oxjd263z 125 7 - - HYPH cord-348409-oxjd263z 125 8 based base VBN cord-348409-oxjd263z 125 9 vaccines vaccine NNS cord-348409-oxjd263z 125 10 has have VBZ cord-348409-oxjd263z 125 11 been be VBN cord-348409-oxjd263z 125 12 to to TO cord-348409-oxjd263z 125 13 target target VB cord-348409-oxjd263z 125 14 infectious infectious JJ cord-348409-oxjd263z 125 15 diseases disease NNS cord-348409-oxjd263z 125 16 in in IN cord-348409-oxjd263z 125 17 animals animal NNS cord-348409-oxjd263z 125 18 . . . cord-348409-oxjd263z 126 1 Studies study NNS cord-348409-oxjd263z 126 2 have have VBP cord-348409-oxjd263z 126 3 shown show VBN cord-348409-oxjd263z 126 4 that that IN cord-348409-oxjd263z 126 5 IAVs iav NNS cord-348409-oxjd263z 126 6 have have VBP cord-348409-oxjd263z 126 7 been be VBN cord-348409-oxjd263z 126 8 constructed construct VBN cord-348409-oxjd263z 126 9 to to TO cord-348409-oxjd263z 126 10 protect protect VB cord-348409-oxjd263z 126 11 vaccinated vaccinated JJ cord-348409-oxjd263z 126 12 animals animal NNS cord-348409-oxjd263z 126 13 against against IN cord-348409-oxjd263z 126 14 a a DT cord-348409-oxjd263z 126 15 variety variety NN cord-348409-oxjd263z 126 16 of of IN cord-348409-oxjd263z 126 17 infectious infectious JJ cord-348409-oxjd263z 126 18 diseases disease NNS cord-348409-oxjd263z 126 19 by by IN cord-348409-oxjd263z 126 20 eliciting elicit VBG cord-348409-oxjd263z 126 21 both both DT cord-348409-oxjd263z 126 22 humoral humoral JJ cord-348409-oxjd263z 126 23 [ [ -LRB- cord-348409-oxjd263z 126 24 82 82 CD cord-348409-oxjd263z 126 25 ] ] -RRB- cord-348409-oxjd263z 126 26 and and CC cord-348409-oxjd263z 126 27 cellular cellular JJ cord-348409-oxjd263z 126 28 [ [ -LRB- cord-348409-oxjd263z 126 29 86 86 CD cord-348409-oxjd263z 126 30 ] ] -RRB- cord-348409-oxjd263z 126 31 immune immune JJ cord-348409-oxjd263z 126 32 responses response NNS cord-348409-oxjd263z 126 33 . . . cord-348409-oxjd263z 127 1 To to TO cord-348409-oxjd263z 127 2 test test VB cord-348409-oxjd263z 127 3 the the DT cord-348409-oxjd263z 127 4 efficacy efficacy NN cord-348409-oxjd263z 127 5 of of IN cord-348409-oxjd263z 127 6 IAV IAV NNP cord-348409-oxjd263z 127 7 vaccines vaccine NNS cord-348409-oxjd263z 127 8 against against IN cord-348409-oxjd263z 127 9 target target NN cord-348409-oxjd263z 127 10 pathogens pathogen NNS cord-348409-oxjd263z 127 11 , , , cord-348409-oxjd263z 127 12 studies study NNS cord-348409-oxjd263z 127 13 were be VBD cord-348409-oxjd263z 127 14 conducted conduct VBN cord-348409-oxjd263z 127 15 in in IN cord-348409-oxjd263z 127 16 which which WDT cord-348409-oxjd263z 127 17 animals animal NNS cord-348409-oxjd263z 127 18 were be VBD cord-348409-oxjd263z 127 19 challenged challenge VBN cord-348409-oxjd263z 127 20 with with IN cord-348409-oxjd263z 127 21 a a DT cord-348409-oxjd263z 127 22 specific specific JJ cord-348409-oxjd263z 127 23 pathogen pathogen NN cord-348409-oxjd263z 127 24 following follow VBG cord-348409-oxjd263z 127 25 IAV IAV NNP cord-348409-oxjd263z 127 26 vaccination vaccination NN cord-348409-oxjd263z 127 27 . . . cord-348409-oxjd263z 128 1 In in IN cord-348409-oxjd263z 128 2 these these DT cord-348409-oxjd263z 128 3 studies study NNS cord-348409-oxjd263z 128 4 , , , cord-348409-oxjd263z 128 5 IAVs iav NNS cord-348409-oxjd263z 128 6 were be VBD cord-348409-oxjd263z 128 7 shown show VBN cord-348409-oxjd263z 128 8 to to TO cord-348409-oxjd263z 128 9 mitigate mitigate VB cord-348409-oxjd263z 128 10 or or CC cord-348409-oxjd263z 128 11 prevent prevent VB cord-348409-oxjd263z 128 12 infection infection NN cord-348409-oxjd263z 128 13 from from IN cord-348409-oxjd263z 128 14 viruses virus NNS cord-348409-oxjd263z 128 15 and and CC cord-348409-oxjd263z 128 16 parasites parasite NNS cord-348409-oxjd263z 128 17 . . . cord-348409-oxjd263z 129 1 In in IN cord-348409-oxjd263z 129 2 one one CD cord-348409-oxjd263z 129 3 study study NN cord-348409-oxjd263z 129 4 , , , cord-348409-oxjd263z 129 5 mice mouse NNS cord-348409-oxjd263z 129 6 were be VBD cord-348409-oxjd263z 129 7 completely completely RB cord-348409-oxjd263z 129 8 vaccinated vaccinate VBN cord-348409-oxjd263z 129 9 against against IN cord-348409-oxjd263z 129 10 Human human JJ cord-348409-oxjd263z 129 11 Respiratory Respiratory NNP cord-348409-oxjd263z 129 12 Syncytial Syncytial NNP cord-348409-oxjd263z 129 13 Virus virus NN cord-348409-oxjd263z 129 14 ( ( -LRB- cord-348409-oxjd263z 129 15 RSV RSV NNP cord-348409-oxjd263z 129 16 ) ) -RRB- cord-348409-oxjd263z 129 17 by by IN cord-348409-oxjd263z 129 18 binding bind VBG cord-348409-oxjd263z 129 19 a a DT cord-348409-oxjd263z 129 20 15-mer 15-mer CD cord-348409-oxjd263z 129 21 linear linear JJ cord-348409-oxjd263z 129 22 epitope epitope NN cord-348409-oxjd263z 129 23 to to IN cord-348409-oxjd263z 129 24 gp3 gp3 NNP cord-348409-oxjd263z 129 25 , , , cord-348409-oxjd263z 129 26 which which WDT cord-348409-oxjd263z 129 27 induced induce VBD cord-348409-oxjd263z 129 28 a a DT cord-348409-oxjd263z 129 29 humoral humoral JJ cord-348409-oxjd263z 129 30 response response NN cord-348409-oxjd263z 129 31 [ [ -LRB- cord-348409-oxjd263z 129 32 56 56 CD cord-348409-oxjd263z 129 33 ] ] -RRB- cord-348409-oxjd263z 129 34 . . . cord-348409-oxjd263z 130 1 Monoclonal monoclonal JJ cord-348409-oxjd263z 130 2 antibodies antibody NNS cord-348409-oxjd263z 130 3 against against IN cord-348409-oxjd263z 130 4 various various JJ cord-348409-oxjd263z 130 5 viral viral JJ cord-348409-oxjd263z 130 6 diseases disease NNS cord-348409-oxjd263z 130 7 have have VBP cord-348409-oxjd263z 130 8 also also RB cord-348409-oxjd263z 130 9 been be VBN cord-348409-oxjd263z 130 10 successfully successfully RB cord-348409-oxjd263z 130 11 screened screen VBN cord-348409-oxjd263z 130 12 against against IN cord-348409-oxjd263z 130 13 RPLs rpl NNS cord-348409-oxjd263z 130 14 to to TO cord-348409-oxjd263z 130 15 produce produce VB cord-348409-oxjd263z 130 16 recombinant recombinant JJ cord-348409-oxjd263z 130 17 inovirus inovirus NNP cord-348409-oxjd263z 130 18 vaccines vaccine NNS cord-348409-oxjd263z 130 19 against against IN cord-348409-oxjd263z 130 20 Herpes Herpes NNP cord-348409-oxjd263z 130 21 Simplex Simplex NNP cord-348409-oxjd263z 130 22 Virus Virus NNP cord-348409-oxjd263z 130 23 type type NN cord-348409-oxjd263z 130 24 2 2 CD cord-348409-oxjd263z 131 1 ( ( -LRB- cord-348409-oxjd263z 131 2 HSV-2 HSV-2 NNP cord-348409-oxjd263z 131 3 ) ) -RRB- cord-348409-oxjd263z 131 4 using use VBG cord-348409-oxjd263z 131 5 a a DT cord-348409-oxjd263z 131 6 15-mer 15-mer CD cord-348409-oxjd263z 131 7 peptide peptide NN cord-348409-oxjd263z 131 8 [ [ -LRB- cord-348409-oxjd263z 131 9 57 57 CD cord-348409-oxjd263z 131 10 ] ] -RRB- cord-348409-oxjd263z 131 11 and and CC cord-348409-oxjd263z 131 12 against against IN cord-348409-oxjd263z 131 13 Neurotropic Neurotropic NNP cord-348409-oxjd263z 131 14 Murine Murine NNP cord-348409-oxjd263z 131 15 Coronavirus Coronavirus NNP cord-348409-oxjd263z 131 16 sing sing VBP cord-348409-oxjd263z 131 17 a a DT cord-348409-oxjd263z 131 18 13mer 13mer JJ cord-348409-oxjd263z 131 19 peptide peptide NN cord-348409-oxjd263z 131 20 [ [ -LRB- cord-348409-oxjd263z 131 21 58 58 CD cord-348409-oxjd263z 131 22 ] ] -RRB- cord-348409-oxjd263z 131 23 . . . cord-348409-oxjd263z 132 1 These these DT cord-348409-oxjd263z 132 2 inovirus inovirus NNP cord-348409-oxjd263z 132 3 vaccines vaccine NNS cord-348409-oxjd263z 132 4 induced induce VBD cord-348409-oxjd263z 132 5 humoral humoral JJ cord-348409-oxjd263z 132 6 responses response NNS cord-348409-oxjd263z 132 7 in in IN cord-348409-oxjd263z 132 8 mice mouse NNS cord-348409-oxjd263z 132 9 , , , cord-348409-oxjd263z 132 10 greatly greatly RB cord-348409-oxjd263z 132 11 reducing reduce VBG cord-348409-oxjd263z 132 12 mortality mortality NN cord-348409-oxjd263z 132 13 and and CC cord-348409-oxjd263z 132 14 providing provide VBG cord-348409-oxjd263z 132 15 protection protection NN cord-348409-oxjd263z 132 16 relative relative JJ cord-348409-oxjd263z 132 17 to to IN cord-348409-oxjd263z 132 18 the the DT cord-348409-oxjd263z 132 19 dose dose NN cord-348409-oxjd263z 132 20 of of IN cord-348409-oxjd263z 132 21 the the DT cord-348409-oxjd263z 132 22 vaccine vaccine NN cord-348409-oxjd263z 132 23 [ [ -LRB- cord-348409-oxjd263z 132 24 57 57 CD cord-348409-oxjd263z 132 25 ] ] -RRB- cord-348409-oxjd263z 132 26 . . . cord-348409-oxjd263z 133 1 IAV IAV NNP cord-348409-oxjd263z 133 2 vaccines vaccine NNS cord-348409-oxjd263z 133 3 have have VBP cord-348409-oxjd263z 133 4 also also RB cord-348409-oxjd263z 133 5 been be VBN cord-348409-oxjd263z 133 6 developed develop VBN cord-348409-oxjd263z 133 7 against against IN cord-348409-oxjd263z 133 8 fungal fungal JJ cord-348409-oxjd263z 133 9 parasites parasite NNS cord-348409-oxjd263z 133 10 in in IN cord-348409-oxjd263z 133 11 animals animal NNS cord-348409-oxjd263z 133 12 , , , cord-348409-oxjd263z 133 13 providing provide VBG cord-348409-oxjd263z 133 14 both both DT cord-348409-oxjd263z 133 15 individual individual JJ cord-348409-oxjd263z 133 16 protection protection NN cord-348409-oxjd263z 133 17 and and CC cord-348409-oxjd263z 133 18 large large JJ cord-348409-oxjd263z 133 19 scale scale NN cord-348409-oxjd263z 133 20 vaccination vaccination NN cord-348409-oxjd263z 133 21 success success NN cord-348409-oxjd263z 133 22 . . . cord-348409-oxjd263z 134 1 [ [ -LRB- cord-348409-oxjd263z 134 2 59 59 CD cord-348409-oxjd263z 134 3 , , , cord-348409-oxjd263z 134 4 60 60 CD cord-348409-oxjd263z 134 5 ] ] -RRB- cord-348409-oxjd263z 134 6 . . . cord-348409-oxjd263z 135 1 Not not RB cord-348409-oxjd263z 135 2 only only RB cord-348409-oxjd263z 135 3 did do VBD cord-348409-oxjd263z 135 4 vaccination vaccination NN cord-348409-oxjd263z 135 5 lower lower VB cord-348409-oxjd263z 135 6 the the DT cord-348409-oxjd263z 135 7 burden burden NN cord-348409-oxjd263z 135 8 of of IN cord-348409-oxjd263z 135 9 infection infection NN cord-348409-oxjd263z 135 10 , , , cord-348409-oxjd263z 135 11 but but CC cord-348409-oxjd263z 135 12 it -PRON- PRP cord-348409-oxjd263z 135 13 also also RB cord-348409-oxjd263z 135 14 increased increase VBD cord-348409-oxjd263z 135 15 the the DT cord-348409-oxjd263z 135 16 lifespan lifespan NN cord-348409-oxjd263z 135 17 in in IN cord-348409-oxjd263z 135 18 the the DT cord-348409-oxjd263z 135 19 infected infected JJ cord-348409-oxjd263z 135 20 mice mouse NNS cord-348409-oxjd263z 135 21 [ [ -LRB- cord-348409-oxjd263z 135 22 59 59 CD cord-348409-oxjd263z 135 23 ] ] -RRB- cord-348409-oxjd263z 135 24 . . . cord-348409-oxjd263z 136 1 In in IN cord-348409-oxjd263z 136 2 2004 2004 CD cord-348409-oxjd263z 136 3 , , , cord-348409-oxjd263z 136 4 Manoutsarian Manoutsarian NNP cord-348409-oxjd263z 136 5 et et NNP cord-348409-oxjd263z 136 6 al al NNP cord-348409-oxjd263z 136 7 . . . cord-348409-oxjd263z 136 8 used use VBD cord-348409-oxjd263z 136 9 IAVs iav NNS cord-348409-oxjd263z 136 10 to to TO cord-348409-oxjd263z 136 11 vaccinate vaccinate VB cord-348409-oxjd263z 136 12 pigs pig NNS cord-348409-oxjd263z 136 13 against against IN cord-348409-oxjd263z 136 14 Taenia Taenia NNP cord-348409-oxjd263z 136 15 solium solium NN cord-348409-oxjd263z 136 16 , , , cord-348409-oxjd263z 136 17 a a DT cord-348409-oxjd263z 136 18 parasitic parasitic JJ cord-348409-oxjd263z 136 19 worm worm NN cord-348409-oxjd263z 136 20 which which WDT cord-348409-oxjd263z 136 21 causes cause VBZ cord-348409-oxjd263z 136 22 neurocysticercosis neurocysticercosis NN cord-348409-oxjd263z 136 23 in in IN cord-348409-oxjd263z 136 24 humans human NNS cord-348409-oxjd263z 136 25 but but CC cord-348409-oxjd263z 136 26 uses use VBZ cord-348409-oxjd263z 136 27 pigs pig NNS cord-348409-oxjd263z 136 28 as as IN cord-348409-oxjd263z 136 29 intermediate intermediate JJ cord-348409-oxjd263z 136 30 hosts host NNS cord-348409-oxjd263z 136 31 . . . cord-348409-oxjd263z 137 1 Unlike unlike IN cord-348409-oxjd263z 137 2 previous previous JJ cord-348409-oxjd263z 137 3 studies study NNS cord-348409-oxjd263z 137 4 , , , cord-348409-oxjd263z 137 5 which which WDT cord-348409-oxjd263z 137 6 used use VBD cord-348409-oxjd263z 137 7 a a DT cord-348409-oxjd263z 137 8 single single JJ cord-348409-oxjd263z 137 9 specific specific JJ cord-348409-oxjd263z 137 10 peptide peptide NN cord-348409-oxjd263z 137 11 fused fuse VBN cord-348409-oxjd263z 137 12 to to IN cord-348409-oxjd263z 137 13 a a DT cord-348409-oxjd263z 137 14 inovirus inovirus NNP cord-348409-oxjd263z 137 15 , , , cord-348409-oxjd263z 137 16 four four CD cord-348409-oxjd263z 137 17 different different JJ cord-348409-oxjd263z 137 18 antigenic antigenic JJ cord-348409-oxjd263z 137 19 peptides peptide NNS cord-348409-oxjd263z 137 20 were be VBD cord-348409-oxjd263z 137 21 displayed display VBN cord-348409-oxjd263z 137 22 by by IN cord-348409-oxjd263z 137 23 inoviruses inoviruse NNS cord-348409-oxjd263z 137 24 in in IN cord-348409-oxjd263z 137 25 a a DT cord-348409-oxjd263z 137 26 cocktail cocktail NN cord-348409-oxjd263z 137 27 of of IN cord-348409-oxjd263z 137 28 recombinant recombinant JJ cord-348409-oxjd263z 137 29 IAVs iav NNS cord-348409-oxjd263z 137 30 . . . cord-348409-oxjd263z 138 1 The the DT cord-348409-oxjd263z 138 2 induction induction NN cord-348409-oxjd263z 138 3 of of IN cord-348409-oxjd263z 138 4 a a DT cord-348409-oxjd263z 138 5 cellular cellular JJ cord-348409-oxjd263z 138 6 response response NN cord-348409-oxjd263z 138 7 completely completely RB cord-348409-oxjd263z 138 8 vaccinated vaccinate VBD cord-348409-oxjd263z 138 9 1/3 1/3 CD cord-348409-oxjd263z 138 10 of of IN cord-348409-oxjd263z 138 11 the the DT cord-348409-oxjd263z 138 12 pigs pig NNS cord-348409-oxjd263z 138 13 in in IN cord-348409-oxjd263z 138 14 the the DT cord-348409-oxjd263z 138 15 study study NN cord-348409-oxjd263z 138 16 and and CC cord-348409-oxjd263z 138 17 reduced reduce VBD cord-348409-oxjd263z 138 18 the the DT cord-348409-oxjd263z 138 19 number number NN cord-348409-oxjd263z 138 20 of of IN cord-348409-oxjd263z 138 21 cysticerci cysticerci NNP cord-348409-oxjd263z 138 22 in in IN cord-348409-oxjd263z 138 23 all all DT cord-348409-oxjd263z 138 24 other other JJ cord-348409-oxjd263z 138 25 pigs pig NNS cord-348409-oxjd263z 138 26 [ [ -LRB- cord-348409-oxjd263z 138 27 61 61 CD cord-348409-oxjd263z 138 28 ] ] -RRB- cord-348409-oxjd263z 138 29 . . . cord-348409-oxjd263z 139 1 Following follow VBG cord-348409-oxjd263z 139 2 the the DT cord-348409-oxjd263z 139 3 success success NN cord-348409-oxjd263z 139 4 of of IN cord-348409-oxjd263z 139 5 this this DT cord-348409-oxjd263z 139 6 study study NN cord-348409-oxjd263z 139 7 , , , cord-348409-oxjd263z 139 8 a a DT cord-348409-oxjd263z 139 9 large large JJ cord-348409-oxjd263z 139 10 - - HYPH cord-348409-oxjd263z 139 11 scale scale NN cord-348409-oxjd263z 139 12 vaccination vaccination NN cord-348409-oxjd263z 139 13 of of IN cord-348409-oxjd263z 139 14 1047 1047 CD cord-348409-oxjd263z 139 15 pigs pig NNS cord-348409-oxjd263z 139 16 in in IN cord-348409-oxjd263z 139 17 Mexico Mexico NNP cord-348409-oxjd263z 139 18 was be VBD cord-348409-oxjd263z 139 19 undertaken undertake VBN cord-348409-oxjd263z 139 20 in in IN cord-348409-oxjd263z 139 21 2008 2008 CD cord-348409-oxjd263z 139 22 . . . cord-348409-oxjd263z 140 1 The the DT cord-348409-oxjd263z 140 2 pigs pig NNS cord-348409-oxjd263z 140 3 in in IN cord-348409-oxjd263z 140 4 a a DT cord-348409-oxjd263z 140 5 natural natural JJ cord-348409-oxjd263z 140 6 environment environment NN cord-348409-oxjd263z 140 7 were be VBD cord-348409-oxjd263z 140 8 successfully successfully RB cord-348409-oxjd263z 140 9 immunized immunize VBN cord-348409-oxjd263z 140 10 , , , cord-348409-oxjd263z 140 11 reducing reduce VBG cord-348409-oxjd263z 140 12 parasite parasite NN cord-348409-oxjd263z 140 13 presence presence NN cord-348409-oxjd263z 140 14 in in IN cord-348409-oxjd263z 140 15 the the DT cord-348409-oxjd263z 140 16 vaccinated vaccinated JJ cord-348409-oxjd263z 140 17 pigs pig NNS cord-348409-oxjd263z 140 18 , , , cord-348409-oxjd263z 140 19 and and CC cord-348409-oxjd263z 140 20 providing provide VBG cord-348409-oxjd263z 140 21 a a DT cord-348409-oxjd263z 140 22 more more RBR cord-348409-oxjd263z 140 23 costefficient costefficient JJ cord-348409-oxjd263z 140 24 alternative alternative NN cord-348409-oxjd263z 140 25 to to IN cord-348409-oxjd263z 140 26 vaccination vaccination NN cord-348409-oxjd263z 140 27 with with IN cord-348409-oxjd263z 140 28 synthetic synthetic JJ cord-348409-oxjd263z 140 29 peptides peptide NNS cord-348409-oxjd263z 140 30 [ [ -LRB- cord-348409-oxjd263z 140 31 87 87 CD cord-348409-oxjd263z 140 32 ] ] -RRB- cord-348409-oxjd263z 140 33 . . . cord-348409-oxjd263z 141 1 Many many JJ cord-348409-oxjd263z 141 2 additional additional JJ cord-348409-oxjd263z 141 3 vaccines vaccine NNS cord-348409-oxjd263z 141 4 have have VBP cord-348409-oxjd263z 141 5 been be VBN cord-348409-oxjd263z 141 6 developed develop VBN cord-348409-oxjd263z 141 7 that that WDT cord-348409-oxjd263z 141 8 induced induce VBN cord-348409-oxjd263z 141 9 both both CC cord-348409-oxjd263z 141 10 humoral humoral JJ cord-348409-oxjd263z 141 11 and and CC cord-348409-oxjd263z 141 12 cellular cellular JJ cord-348409-oxjd263z 141 13 responses response NNS cord-348409-oxjd263z 141 14 against against IN cord-348409-oxjd263z 141 15 parasites parasite NNS cord-348409-oxjd263z 141 16 in in IN cord-348409-oxjd263z 141 17 animals animal NNS cord-348409-oxjd263z 141 18 providing provide VBG cord-348409-oxjd263z 141 19 partial partial JJ cord-348409-oxjd263z 141 20 protection protection NN cord-348409-oxjd263z 141 21 against against IN cord-348409-oxjd263z 141 22 the the DT cord-348409-oxjd263z 141 23 infection infection NN cord-348409-oxjd263z 141 24 and and CC cord-348409-oxjd263z 141 25 reducing reduce VBG cord-348409-oxjd263z 141 26 infection infection NN cord-348409-oxjd263z 141 27 burden burden NN cord-348409-oxjd263z 141 28 . . . cord-348409-oxjd263z 142 1 Many many JJ cord-348409-oxjd263z 142 2 of of IN cord-348409-oxjd263z 142 3 these these DT cord-348409-oxjd263z 142 4 studies study NNS cord-348409-oxjd263z 142 5 were be VBD cord-348409-oxjd263z 142 6 done do VBN cord-348409-oxjd263z 142 7 by by IN cord-348409-oxjd263z 142 8 screening screen VBG cord-348409-oxjd263z 142 9 monoclonal monoclonal JJ cord-348409-oxjd263z 142 10 and and CC cord-348409-oxjd263z 142 11 polyclonal polyclonal JJ cord-348409-oxjd263z 142 12 antibodies antibody NNS cord-348409-oxjd263z 142 13 against against IN cord-348409-oxjd263z 142 14 large large JJ cord-348409-oxjd263z 142 15 RPL rpl NN cord-348409-oxjd263z 142 16 ( ( -LRB- cord-348409-oxjd263z 142 17 for for IN cord-348409-oxjd263z 142 18 a a DT cord-348409-oxjd263z 142 19 review review NN cord-348409-oxjd263z 142 20 of of IN cord-348409-oxjd263z 142 21 more more JJR cord-348409-oxjd263z 142 22 inovirus inovirus NNP cord-348409-oxjd263z 142 23 vaccine vaccine NN cord-348409-oxjd263z 142 24 studies study NNS cord-348409-oxjd263z 142 25 see see VBP cord-348409-oxjd263z 142 26 [ [ -LRB- cord-348409-oxjd263z 142 27 31 31 CD cord-348409-oxjd263z 142 28 ] ] -RRB- cord-348409-oxjd263z 142 29 ) ) -RRB- cord-348409-oxjd263z 142 30 . . . cord-348409-oxjd263z 143 1 In in IN cord-348409-oxjd263z 143 2 addition addition NN cord-348409-oxjd263z 143 3 to to IN cord-348409-oxjd263z 143 4 their -PRON- PRP$ cord-348409-oxjd263z 143 5 success success NN cord-348409-oxjd263z 143 6 against against IN cord-348409-oxjd263z 143 7 infectious infectious JJ cord-348409-oxjd263z 143 8 diseases disease NNS cord-348409-oxjd263z 143 9 , , , cord-348409-oxjd263z 143 10 inovirus inovirus NNP cord-348409-oxjd263z 143 11 display display NN cord-348409-oxjd263z 143 12 technology technology NN cord-348409-oxjd263z 143 13 has have VBZ cord-348409-oxjd263z 143 14 been be VBN cord-348409-oxjd263z 143 15 successfully successfully RB cord-348409-oxjd263z 143 16 used use VBN cord-348409-oxjd263z 143 17 to to TO cord-348409-oxjd263z 143 18 design design VB cord-348409-oxjd263z 143 19 vaccines vaccine NNS cord-348409-oxjd263z 143 20 which which WDT cord-348409-oxjd263z 143 21 prevent prevent VBP cord-348409-oxjd263z 143 22 or or CC cord-348409-oxjd263z 143 23 mitigate mitigate VB cord-348409-oxjd263z 143 24 the the DT cord-348409-oxjd263z 143 25 progression progression NN cord-348409-oxjd263z 143 26 of of IN cord-348409-oxjd263z 143 27 non non JJ cord-348409-oxjd263z 143 28 - - JJ cord-348409-oxjd263z 143 29 infectious infectious JJ cord-348409-oxjd263z 143 30 diseases disease NNS cord-348409-oxjd263z 143 31 . . . cord-348409-oxjd263z 144 1 IAVs iav NNS cord-348409-oxjd263z 144 2 have have VBP cord-348409-oxjd263z 144 3 been be VBN cord-348409-oxjd263z 144 4 used use VBN cord-348409-oxjd263z 144 5 to to TO cord-348409-oxjd263z 144 6 display display VB cord-348409-oxjd263z 144 7 antigen antigen NN cord-348409-oxjd263z 144 8 epitopes epitope NNS cord-348409-oxjd263z 144 9 which which WDT cord-348409-oxjd263z 144 10 elicit elicit VBP cord-348409-oxjd263z 144 11 immune immune JJ cord-348409-oxjd263z 144 12 responses response NNS cord-348409-oxjd263z 144 13 against against IN cord-348409-oxjd263z 144 14 tumors tumor NNS cord-348409-oxjd263z 144 15 and and CC cord-348409-oxjd263z 144 16 other other JJ cord-348409-oxjd263z 144 17 non non JJ cord-348409-oxjd263z 144 18 - - JJ cord-348409-oxjd263z 144 19 infectious infectious JJ cord-348409-oxjd263z 144 20 diseases disease NNS cord-348409-oxjd263z 144 21 . . . cord-348409-oxjd263z 145 1 An an DT cord-348409-oxjd263z 145 2 epitope epitope NN cord-348409-oxjd263z 145 3 of of IN cord-348409-oxjd263z 145 4 the the DT cord-348409-oxjd263z 145 5 Melanoma Melanoma NNP cord-348409-oxjd263z 145 6 Antigen Antigen NNP cord-348409-oxjd263z 145 7 A1 A1 NNP cord-348409-oxjd263z 145 8 ( ( -LRB- cord-348409-oxjd263z 145 9 MAGE MAGE NNP cord-348409-oxjd263z 145 10 A1 A1 NNP cord-348409-oxjd263z 145 11 ) ) -RRB- cord-348409-oxjd263z 145 12 displayed display VBD cord-348409-oxjd263z 145 13 on on IN cord-348409-oxjd263z 145 14 gp8 gp8 NN cord-348409-oxjd263z 145 15 induced induce VBN cord-348409-oxjd263z 145 16 a a DT cord-348409-oxjd263z 145 17 cellular cellular JJ cord-348409-oxjd263z 145 18 immune immune JJ cord-348409-oxjd263z 145 19 response response NN cord-348409-oxjd263z 145 20 against against IN cord-348409-oxjd263z 145 21 the the DT cord-348409-oxjd263z 145 22 melanoma melanoma NN cord-348409-oxjd263z 145 23 tumor tumor NN cord-348409-oxjd263z 145 24 in in IN cord-348409-oxjd263z 145 25 vaccinated vaccinated JJ cord-348409-oxjd263z 145 26 mice mouse NNS cord-348409-oxjd263z 145 27 . . . cord-348409-oxjd263z 146 1 Not not RB cord-348409-oxjd263z 146 2 only only RB cord-348409-oxjd263z 146 3 did do VBD cord-348409-oxjd263z 146 4 vaccination vaccination NN cord-348409-oxjd263z 146 5 inhibit inhibit NN cord-348409-oxjd263z 146 6 tumor tumor NN cord-348409-oxjd263z 146 7 growth growth NN cord-348409-oxjd263z 146 8 , , , cord-348409-oxjd263z 146 9 but but CC cord-348409-oxjd263z 146 10 it -PRON- PRP cord-348409-oxjd263z 146 11 reduced reduce VBD cord-348409-oxjd263z 146 12 mortality mortality NN cord-348409-oxjd263z 146 13 in in IN cord-348409-oxjd263z 146 14 the the DT cord-348409-oxjd263z 146 15 targeted targeted JJ cord-348409-oxjd263z 146 16 mice mouse NNS cord-348409-oxjd263z 146 17 [ [ -LRB- cord-348409-oxjd263z 146 18 88 88 CD cord-348409-oxjd263z 146 19 ] ] -RRB- cord-348409-oxjd263z 146 20 . . . cord-348409-oxjd263z 147 1 Induction induction NN cord-348409-oxjd263z 147 2 of of IN cord-348409-oxjd263z 147 3 a a DT cord-348409-oxjd263z 147 4 cellular cellular JJ cord-348409-oxjd263z 147 5 response response NN cord-348409-oxjd263z 147 6 , , , cord-348409-oxjd263z 147 7 decreased decrease VBD cord-348409-oxjd263z 147 8 tumor tumor NN cord-348409-oxjd263z 147 9 growth growth NN cord-348409-oxjd263z 147 10 , , , cord-348409-oxjd263z 147 11 and and CC cord-348409-oxjd263z 147 12 higher high JJR cord-348409-oxjd263z 147 13 survival survival NN cord-348409-oxjd263z 147 14 rate rate NN cord-348409-oxjd263z 147 15 was be VBD cord-348409-oxjd263z 147 16 observed observe VBN cord-348409-oxjd263z 147 17 in in IN cord-348409-oxjd263z 147 18 mice mouse NNS cord-348409-oxjd263z 147 19 vaccinated vaccinate VBN cord-348409-oxjd263z 147 20 against against IN cord-348409-oxjd263z 147 21 murine murine JJ cord-348409-oxjd263z 147 22 mastocytoma mastocytoma NNP cord-348409-oxjd263z 147 23 P815 P815 '' cord-348409-oxjd263z 147 24 in in IN cord-348409-oxjd263z 147 25 a a DT cord-348409-oxjd263z 147 26 later later JJ cord-348409-oxjd263z 147 27 study study NN cord-348409-oxjd263z 147 28 [ [ -LRB- cord-348409-oxjd263z 147 29 89 89 CD cord-348409-oxjd263z 147 30 ] ] -RRB- cord-348409-oxjd263z 147 31 . . . cord-348409-oxjd263z 148 1 The the DT cord-348409-oxjd263z 148 2 highly highly RB cord-348409-oxjd263z 148 3 immunogenic immunogenic JJ cord-348409-oxjd263z 148 4 characteristics characteristic NNS cord-348409-oxjd263z 148 5 of of IN cord-348409-oxjd263z 148 6 inovirus inovirus NNP cord-348409-oxjd263z 148 7 display display NN cord-348409-oxjd263z 148 8 technology technology NN cord-348409-oxjd263z 148 9 has have VBZ cord-348409-oxjd263z 148 10 also also RB cord-348409-oxjd263z 148 11 been be VBN cord-348409-oxjd263z 148 12 used use VBN cord-348409-oxjd263z 148 13 to to TO cord-348409-oxjd263z 148 14 activate activate VB cord-348409-oxjd263z 148 15 immune immune JJ cord-348409-oxjd263z 148 16 responses response NNS cord-348409-oxjd263z 148 17 against against IN cord-348409-oxjd263z 148 18 colorectal colorectal JJ cord-348409-oxjd263z 148 19 cancer cancer NN cord-348409-oxjd263z 148 20 tumors tumor NNS cord-348409-oxjd263z 148 21 , , , cord-348409-oxjd263z 148 22 which which WDT cord-348409-oxjd263z 148 23 often often RB cord-348409-oxjd263z 148 24 evade evade VBP cord-348409-oxjd263z 148 25 antitumor antitumor JJ cord-348409-oxjd263z 148 26 immune immune JJ cord-348409-oxjd263z 148 27 responses response NNS cord-348409-oxjd263z 148 28 , , , cord-348409-oxjd263z 148 29 and and CC cord-348409-oxjd263z 148 30 to to TO cord-348409-oxjd263z 148 31 reduce reduce VB cord-348409-oxjd263z 148 32 tumor tumor NN cord-348409-oxjd263z 148 33 growth growth NN cord-348409-oxjd263z 148 34 [ [ -LRB- cord-348409-oxjd263z 148 35 90 90 CD cord-348409-oxjd263z 148 36 ] ] -RRB- cord-348409-oxjd263z 148 37 . . . cord-348409-oxjd263z 149 1 Inovirus Inovirus NNP cord-348409-oxjd263z 149 2 - - HYPH cord-348409-oxjd263z 149 3 based base VBN cord-348409-oxjd263z 149 4 vaccines vaccine NNS cord-348409-oxjd263z 149 5 have have VBP cord-348409-oxjd263z 149 6 also also RB cord-348409-oxjd263z 149 7 been be VBN cord-348409-oxjd263z 149 8 used use VBN cord-348409-oxjd263z 149 9 against against IN cord-348409-oxjd263z 149 10 diseases disease NNS cord-348409-oxjd263z 149 11 such such JJ cord-348409-oxjd263z 149 12 as as IN cord-348409-oxjd263z 149 13 Alzheimer Alzheimer NNP cord-348409-oxjd263z 149 14 's 's POS cord-348409-oxjd263z 149 15 . . . cord-348409-oxjd263z 150 1 The the DT cord-348409-oxjd263z 150 2 same same JJ cord-348409-oxjd263z 150 3 methods method NNS cord-348409-oxjd263z 150 4 have have VBP cord-348409-oxjd263z 150 5 been be VBN cord-348409-oxjd263z 150 6 used use VBN cord-348409-oxjd263z 150 7 to to TO cord-348409-oxjd263z 150 8 induct induct VB cord-348409-oxjd263z 150 9 antibodies antibody NNS cord-348409-oxjd263z 150 10 against against IN cord-348409-oxjd263z 150 11 β β NN cord-348409-oxjd263z 150 12 - - HYPH cord-348409-oxjd263z 150 13 amyloid amyloid NN cord-348409-oxjd263z 150 14 plaques plaque NNS cord-348409-oxjd263z 150 15 by by IN cord-348409-oxjd263z 150 16 displaying display VBG cord-348409-oxjd263z 150 17 a a DT cord-348409-oxjd263z 150 18 specific specific JJ cord-348409-oxjd263z 150 19 4 4 CD cord-348409-oxjd263z 150 20 amino amino NN cord-348409-oxjd263z 150 21 acid acid NN cord-348409-oxjd263z 150 22 antigenic antigenic JJ cord-348409-oxjd263z 150 23 epitope epitope NN cord-348409-oxjd263z 150 24 on on IN cord-348409-oxjd263z 150 25 the the DT cord-348409-oxjd263z 150 26 surface surface NN cord-348409-oxjd263z 150 27 of of IN cord-348409-oxjd263z 150 28 the the DT cord-348409-oxjd263z 150 29 inovirus inovirus NNP cord-348409-oxjd263z 150 30 . . . cord-348409-oxjd263z 151 1 Multiple multiple JJ cord-348409-oxjd263z 151 2 studies study NNS cord-348409-oxjd263z 151 3 in in IN cord-348409-oxjd263z 151 4 mice mouse NNS cord-348409-oxjd263z 151 5 using use VBG cord-348409-oxjd263z 151 6 recombinant recombinant JJ cord-348409-oxjd263z 151 7 inoviruses inoviruse NNS cord-348409-oxjd263z 151 8 have have VBP cord-348409-oxjd263z 151 9 induced induce VBN cord-348409-oxjd263z 151 10 a a DT cord-348409-oxjd263z 151 11 humoral humoral JJ cord-348409-oxjd263z 151 12 response response NN cord-348409-oxjd263z 151 13 and and CC cord-348409-oxjd263z 151 14 reduced reduce VBN cord-348409-oxjd263z 151 15 βamyloid βamyloid NN cord-348409-oxjd263z 151 16 plaque plaque NN cord-348409-oxjd263z 151 17 burden burden NN cord-348409-oxjd263z 151 18 [ [ -LRB- cord-348409-oxjd263z 151 19 91 91 CD cord-348409-oxjd263z 151 20 ] ] -RRB- cord-348409-oxjd263z 151 21 [ [ -LRB- cord-348409-oxjd263z 151 22 92 92 CD cord-348409-oxjd263z 151 23 ] ] -RRB- cord-348409-oxjd263z 151 24 [ [ -LRB- cord-348409-oxjd263z 151 25 93 93 CD cord-348409-oxjd263z 151 26 ] ] -RRB- cord-348409-oxjd263z 151 27 [ [ -LRB- cord-348409-oxjd263z 151 28 94 94 CD cord-348409-oxjd263z 151 29 ] ] -RRB- cord-348409-oxjd263z 151 30 . . . cord-348409-oxjd263z 152 1 While while IN cord-348409-oxjd263z 152 2 not not RB cord-348409-oxjd263z 152 3 used use VBN cord-348409-oxjd263z 152 4 preventatively preventatively RB cord-348409-oxjd263z 152 5 as as IN cord-348409-oxjd263z 152 6 has have VBZ cord-348409-oxjd263z 152 7 been be VBN cord-348409-oxjd263z 152 8 done do VBN cord-348409-oxjd263z 152 9 with with IN cord-348409-oxjd263z 152 10 infectious infectious JJ cord-348409-oxjd263z 152 11 diseases disease NNS cord-348409-oxjd263z 152 12 , , , cord-348409-oxjd263z 152 13 IAVs iav NNS cord-348409-oxjd263z 152 14 can can MD cord-348409-oxjd263z 152 15 vaccinate vaccinate VB cord-348409-oxjd263z 152 16 animals animal NNS cord-348409-oxjd263z 152 17 against against IN cord-348409-oxjd263z 152 18 further further JJ cord-348409-oxjd263z 152 19 disease disease NN cord-348409-oxjd263z 152 20 progression progression NN cord-348409-oxjd263z 152 21 in in IN cord-348409-oxjd263z 152 22 non non JJ cord-348409-oxjd263z 152 23 - - JJ cord-348409-oxjd263z 152 24 infectious infectious JJ cord-348409-oxjd263z 152 25 diseases disease NNS cord-348409-oxjd263z 152 26 . . . cord-348409-oxjd263z 153 1 These these DT cord-348409-oxjd263z 153 2 findings finding NNS cord-348409-oxjd263z 153 3 suggest suggest VBP cord-348409-oxjd263z 153 4 that that IN cord-348409-oxjd263z 153 5 there there EX cord-348409-oxjd263z 153 6 will will MD cord-348409-oxjd263z 153 7 be be VB cord-348409-oxjd263z 153 8 future future JJ cord-348409-oxjd263z 153 9 development development NN cord-348409-oxjd263z 153 10 of of IN cord-348409-oxjd263z 153 11 inovirus inovirus NNP cord-348409-oxjd263z 153 12 - - HYPH cord-348409-oxjd263z 153 13 based base VBN cord-348409-oxjd263z 153 14 vaccines vaccine NNS cord-348409-oxjd263z 153 15 against against IN cord-348409-oxjd263z 153 16 non non JJ cord-348409-oxjd263z 153 17 - - JJ cord-348409-oxjd263z 153 18 infectious infectious JJ cord-348409-oxjd263z 153 19 diseases disease NNS cord-348409-oxjd263z 153 20 that that WDT cord-348409-oxjd263z 153 21 mitigate mitigate VBP cord-348409-oxjd263z 153 22 the the DT cord-348409-oxjd263z 153 23 damage damage NN cord-348409-oxjd263z 153 24 done do VBN cord-348409-oxjd263z 153 25 to to IN cord-348409-oxjd263z 153 26 both both DT cord-348409-oxjd263z 153 27 animals animal NNS cord-348409-oxjd263z 153 28 and and CC cord-348409-oxjd263z 153 29 humans human NNS cord-348409-oxjd263z 153 30 . . . cord-348409-oxjd263z 154 1 Despite despite IN cord-348409-oxjd263z 154 2 the the DT cord-348409-oxjd263z 154 3 advances advance NNS cord-348409-oxjd263z 154 4 in in IN cord-348409-oxjd263z 154 5 the the DT cord-348409-oxjd263z 154 6 use use NN cord-348409-oxjd263z 154 7 of of IN cord-348409-oxjd263z 154 8 IAVs iav NNS cord-348409-oxjd263z 154 9 to to TO cord-348409-oxjd263z 154 10 combat combat NN cord-348409-oxjd263z 154 11 disease disease NN cord-348409-oxjd263z 154 12 , , , cord-348409-oxjd263z 154 13 the the DT cord-348409-oxjd263z 154 14 consistent consistent JJ cord-348409-oxjd263z 154 15 development development NN cord-348409-oxjd263z 154 16 of of IN cord-348409-oxjd263z 154 17 inovirus inovirus NNP cord-348409-oxjd263z 154 18 - - HYPH cord-348409-oxjd263z 154 19 based base VBN cord-348409-oxjd263z 154 20 vaccines vaccine NNS cord-348409-oxjd263z 154 21 still still RB cord-348409-oxjd263z 154 22 faces face VBZ cord-348409-oxjd263z 154 23 challenges challenge NNS cord-348409-oxjd263z 154 24 . . . cord-348409-oxjd263z 155 1 Even even RB cord-348409-oxjd263z 155 2 when when WRB cord-348409-oxjd263z 155 3 inoviruses inoviruse NNS cord-348409-oxjd263z 155 4 have have VBP cord-348409-oxjd263z 155 5 been be VBN cord-348409-oxjd263z 155 6 screened screen VBN cord-348409-oxjd263z 155 7 with with IN cord-348409-oxjd263z 155 8 specific specific JJ cord-348409-oxjd263z 155 9 antibodies antibody NNS cord-348409-oxjd263z 155 10 to to TO cord-348409-oxjd263z 155 11 bear bear VB cord-348409-oxjd263z 155 12 the the DT cord-348409-oxjd263z 155 13 desired desire VBN cord-348409-oxjd263z 155 14 peptide peptide NN cord-348409-oxjd263z 155 15 mimotopes mimotope NNS cord-348409-oxjd263z 155 16 , , , cord-348409-oxjd263z 155 17 immunization immunization NN cord-348409-oxjd263z 155 18 using use VBG cord-348409-oxjd263z 155 19 IAVs iav NNS cord-348409-oxjd263z 155 20 does do VBZ cord-348409-oxjd263z 155 21 not not RB cord-348409-oxjd263z 155 22 always always RB cord-348409-oxjd263z 155 23 produce produce VB cord-348409-oxjd263z 155 24 the the DT cord-348409-oxjd263z 155 25 expected expect VBN cord-348409-oxjd263z 155 26 immune immune JJ cord-348409-oxjd263z 155 27 response response NN cord-348409-oxjd263z 155 28 . . . cord-348409-oxjd263z 156 1 Keller Keller NNP cord-348409-oxjd263z 156 2 et et NNP cord-348409-oxjd263z 156 3 al al NNP cord-348409-oxjd263z 156 4 . . . cord-348409-oxjd263z 157 1 in in IN cord-348409-oxjd263z 157 2 1993 1993 CD cord-348409-oxjd263z 157 3 were be VBD cord-348409-oxjd263z 157 4 unable unable JJ cord-348409-oxjd263z 157 5 to to TO cord-348409-oxjd263z 157 6 induce induce VB cord-348409-oxjd263z 157 7 the the DT cord-348409-oxjd263z 157 8 production production NN cord-348409-oxjd263z 157 9 of of IN cord-348409-oxjd263z 157 10 broadly broadly RB cord-348409-oxjd263z 157 11 neutralizing neutralize VBG cord-348409-oxjd263z 157 12 antibodies antibody NNS cord-348409-oxjd263z 157 13 against against IN cord-348409-oxjd263z 158 1 Human Human NNP cord-348409-oxjd263z 158 2 Immunodeficiency Immunodeficiency NNP cord-348409-oxjd263z 158 3 Virus Virus NNP cord-348409-oxjd263z 158 4 Type-1 type-1 NN cord-348409-oxjd263z 158 5 ( ( -LRB- cord-348409-oxjd263z 158 6 HIV-1 HIV-1 NNP cord-348409-oxjd263z 158 7 ) ) -RRB- cord-348409-oxjd263z 158 8 in in IN cord-348409-oxjd263z 158 9 rabbits rabbit NNS cord-348409-oxjd263z 158 10 despite despite IN cord-348409-oxjd263z 158 11 having have VBG cord-348409-oxjd263z 158 12 screened screen VBN cord-348409-oxjd263z 158 13 for for IN cord-348409-oxjd263z 158 14 the the DT cord-348409-oxjd263z 158 15 proper proper JJ cord-348409-oxjd263z 158 16 mimotopes mimotope NNS cord-348409-oxjd263z 158 17 [ [ -LRB- cord-348409-oxjd263z 158 18 66 66 CD cord-348409-oxjd263z 158 19 ] ] -RRB- cord-348409-oxjd263z 158 20 . . . cord-348409-oxjd263z 159 1 Dorgham Dorgham NNP cord-348409-oxjd263z 159 2 et et FW cord-348409-oxjd263z 159 3 al al NNP cord-348409-oxjd263z 159 4 . . . cord-348409-oxjd263z 160 1 in in IN cord-348409-oxjd263z 160 2 2005 2005 CD cord-348409-oxjd263z 160 3 screened screen VBD cord-348409-oxjd263z 160 4 a a DT cord-348409-oxjd263z 160 5 15-mer 15-mer CD cord-348409-oxjd263z 160 6 RPL rpl NN cord-348409-oxjd263z 160 7 using use VBG cord-348409-oxjd263z 160 8 a a DT cord-348409-oxjd263z 160 9 broadly broadly RB cord-348409-oxjd263z 160 10 neutralizing neutralize VBG cord-348409-oxjd263z 160 11 antibody antibody NN cord-348409-oxjd263z 160 12 and and CC cord-348409-oxjd263z 160 13 , , , cord-348409-oxjd263z 160 14 using use VBG cord-348409-oxjd263z 160 15 the the DT cord-348409-oxjd263z 160 16 selected select VBN cord-348409-oxjd263z 160 17 inoviruses inoviruse NNS cord-348409-oxjd263z 160 18 , , , cord-348409-oxjd263z 160 19 were be VBD cord-348409-oxjd263z 160 20 able able JJ cord-348409-oxjd263z 160 21 to to TO cord-348409-oxjd263z 160 22 induce induce VB cord-348409-oxjd263z 160 23 antibodies antibody NNS cord-348409-oxjd263z 160 24 in in IN cord-348409-oxjd263z 160 25 vaccinated vaccinated JJ cord-348409-oxjd263z 160 26 mice mouse NNS cord-348409-oxjd263z 160 27 . . . cord-348409-oxjd263z 161 1 However however RB cord-348409-oxjd263z 161 2 , , , cord-348409-oxjd263z 161 3 the the DT cord-348409-oxjd263z 161 4 induced induce VBN cord-348409-oxjd263z 161 5 antibodies antibody NNS cord-348409-oxjd263z 161 6 did do VBD cord-348409-oxjd263z 161 7 not not RB cord-348409-oxjd263z 161 8 exhibit exhibit VB cord-348409-oxjd263z 161 9 neutralizing neutralize VBG cord-348409-oxjd263z 161 10 activity activity NN cord-348409-oxjd263z 161 11 against against IN cord-348409-oxjd263z 161 12 HIV-1 HIV-1 NNP cord-348409-oxjd263z 161 13 [ [ -LRB- cord-348409-oxjd263z 161 14 68 68 CD cord-348409-oxjd263z 161 15 ] ] -RRB- cord-348409-oxjd263z 161 16 . . . cord-348409-oxjd263z 162 1 Other other JJ cord-348409-oxjd263z 162 2 RPLs rpls NN cord-348409-oxjd263z 162 3 screened screen VBN cord-348409-oxjd263z 162 4 against against IN cord-348409-oxjd263z 162 5 monoclonal monoclonal JJ cord-348409-oxjd263z 162 6 and and CC cord-348409-oxjd263z 162 7 broadly broadly RB cord-348409-oxjd263z 162 8 neutralizing neutralize VBG cord-348409-oxjd263z 162 9 antibodies antibody NNS cord-348409-oxjd263z 162 10 have have VBP cord-348409-oxjd263z 162 11 produced produce VBN cord-348409-oxjd263z 162 12 antibodies antibody NNS cord-348409-oxjd263z 162 13 that that WDT cord-348409-oxjd263z 162 14 do do VBP cord-348409-oxjd263z 162 15 not not RB cord-348409-oxjd263z 162 16 have have VB cord-348409-oxjd263z 162 17 neutralizing neutralize VBG cord-348409-oxjd263z 162 18 capabilities capability NNS cord-348409-oxjd263z 162 19 [ [ -LRB- cord-348409-oxjd263z 162 20 55 55 CD cord-348409-oxjd263z 162 21 , , , cord-348409-oxjd263z 162 22 70 70 CD cord-348409-oxjd263z 162 23 ] ] -RRB- cord-348409-oxjd263z 162 24 . . . cord-348409-oxjd263z 163 1 In in IN cord-348409-oxjd263z 163 2 one one CD cord-348409-oxjd263z 163 3 such such JJ cord-348409-oxjd263z 163 4 case case NN cord-348409-oxjd263z 163 5 , , , cord-348409-oxjd263z 163 6 crystallization crystallization NN cord-348409-oxjd263z 163 7 of of IN cord-348409-oxjd263z 163 8 the the DT cord-348409-oxjd263z 163 9 specific specific JJ cord-348409-oxjd263z 163 10 mimotope mimotope NN cord-348409-oxjd263z 163 11 revealed reveal VBD cord-348409-oxjd263z 163 12 that that IN cord-348409-oxjd263z 163 13 the the DT cord-348409-oxjd263z 163 14 oligopeptide oligopeptide NN cord-348409-oxjd263z 163 15 borne bear VBN cord-348409-oxjd263z 163 16 by by IN cord-348409-oxjd263z 163 17 the the DT cord-348409-oxjd263z 163 18 inovirus inovirus NNP cord-348409-oxjd263z 163 19 was be VBD cord-348409-oxjd263z 163 20 structurally structurally RB cord-348409-oxjd263z 163 21 different different JJ cord-348409-oxjd263z 163 22 that that IN cord-348409-oxjd263z 163 23 the the DT cord-348409-oxjd263z 163 24 natural natural JJ cord-348409-oxjd263z 163 25 antibody antibody NN cord-348409-oxjd263z 163 26 epitope epitope NN cord-348409-oxjd263z 163 27 [ [ -LRB- cord-348409-oxjd263z 163 28 69 69 CD cord-348409-oxjd263z 163 29 ] ] -RRB- cord-348409-oxjd263z 163 30 . . . cord-348409-oxjd263z 164 1 This this DT cord-348409-oxjd263z 164 2 structural structural JJ cord-348409-oxjd263z 164 3 issue issue NN cord-348409-oxjd263z 164 4 is be VBZ cord-348409-oxjd263z 164 5 likely likely JJ cord-348409-oxjd263z 164 6 at at IN cord-348409-oxjd263z 164 7 the the DT cord-348409-oxjd263z 164 8 foundation foundation NN cord-348409-oxjd263z 164 9 of of IN cord-348409-oxjd263z 164 10 many many JJ cord-348409-oxjd263z 164 11 of of IN cord-348409-oxjd263z 164 12 the the DT cord-348409-oxjd263z 164 13 issues issue NNS cord-348409-oxjd263z 164 14 involving involve VBG cord-348409-oxjd263z 164 15 ineffectual ineffectual JJ cord-348409-oxjd263z 164 16 inovirus inovirus NNP cord-348409-oxjd263z 164 17 - - HYPH cord-348409-oxjd263z 164 18 based base VBN cord-348409-oxjd263z 164 19 vaccines vaccine NNS cord-348409-oxjd263z 164 20 . . . cord-348409-oxjd263z 165 1 When when WRB cord-348409-oxjd263z 165 2 IAVs iav NNS cord-348409-oxjd263z 165 3 fail fail VBP cord-348409-oxjd263z 165 4 , , , cord-348409-oxjd263z 165 5 it -PRON- PRP cord-348409-oxjd263z 165 6 is be VBZ cord-348409-oxjd263z 165 7 probable probable JJ cord-348409-oxjd263z 165 8 that that IN cord-348409-oxjd263z 165 9 the the DT cord-348409-oxjd263z 165 10 chosen choose VBN cord-348409-oxjd263z 165 11 mimotopes mimotope NNS cord-348409-oxjd263z 165 12 poorly poorly RB cord-348409-oxjd263z 165 13 resemble resemble VB cord-348409-oxjd263z 165 14 the the DT cord-348409-oxjd263z 165 15 original original JJ cord-348409-oxjd263z 165 16 antibody antibody NN cord-348409-oxjd263z 165 17 epitopes epitope NNS cord-348409-oxjd263z 165 18 and and CC cord-348409-oxjd263z 165 19 can can MD cord-348409-oxjd263z 165 20 not not RB cord-348409-oxjd263z 165 21 function function VB cord-348409-oxjd263z 165 22 in in IN cord-348409-oxjd263z 165 23 the the DT cord-348409-oxjd263z 165 24 desired desire VBN cord-348409-oxjd263z 165 25 fashion fashion NN cord-348409-oxjd263z 165 26 , , , cord-348409-oxjd263z 165 27 either either CC cord-348409-oxjd263z 165 28 failing fail VBG cord-348409-oxjd263z 165 29 to to TO cord-348409-oxjd263z 165 30 induce induce VB cord-348409-oxjd263z 165 31 antibodies antibody NNS cord-348409-oxjd263z 165 32 or or CC cord-348409-oxjd263z 165 33 inducing induce VBG cord-348409-oxjd263z 165 34 of of IN cord-348409-oxjd263z 165 35 antibodies antibody NNS cord-348409-oxjd263z 165 36 without without IN cord-348409-oxjd263z 165 37 neutralizing neutralize VBG cord-348409-oxjd263z 165 38 capabilities capability NNS cord-348409-oxjd263z 165 39 . . . cord-348409-oxjd263z 166 1 Despite despite IN cord-348409-oxjd263z 166 2 the the DT cord-348409-oxjd263z 166 3 efficacy efficacy NN cord-348409-oxjd263z 166 4 of of IN cord-348409-oxjd263z 166 5 these these DT cord-348409-oxjd263z 166 6 inovirus inovirus NNP cord-348409-oxjd263z 166 7 - - HYPH cord-348409-oxjd263z 166 8 based base VBN cord-348409-oxjd263z 166 9 vaccines vaccine NNS cord-348409-oxjd263z 166 10 against against IN cord-348409-oxjd263z 166 11 a a DT cord-348409-oxjd263z 166 12 variety variety NN cord-348409-oxjd263z 166 13 of of IN cord-348409-oxjd263z 166 14 infectious infectious JJ cord-348409-oxjd263z 166 15 and and CC cord-348409-oxjd263z 166 16 non non JJ cord-348409-oxjd263z 166 17 - - JJ cord-348409-oxjd263z 166 18 infectious infectious JJ cord-348409-oxjd263z 166 19 diseases disease NNS cord-348409-oxjd263z 166 20 , , , cord-348409-oxjd263z 166 21 there there EX cord-348409-oxjd263z 166 22 are be VBP cord-348409-oxjd263z 166 23 still still RB cord-348409-oxjd263z 166 24 many many JJ cord-348409-oxjd263z 166 25 diseases disease NNS cord-348409-oxjd263z 166 26 for for IN cord-348409-oxjd263z 166 27 which which WDT cord-348409-oxjd263z 166 28 effective effective JJ cord-348409-oxjd263z 166 29 vaccines vaccine NNS cord-348409-oxjd263z 166 30 have have VBP cord-348409-oxjd263z 166 31 not not RB cord-348409-oxjd263z 166 32 been be VBN cord-348409-oxjd263z 166 33 developed develop VBN cord-348409-oxjd263z 166 34 using use VBG cord-348409-oxjd263z 166 35 phage phage NN cord-348409-oxjd263z 166 36 display display NN cord-348409-oxjd263z 166 37 or or CC cord-348409-oxjd263z 166 38 other other JJ cord-348409-oxjd263z 166 39 methods method NNS cord-348409-oxjd263z 166 40 . . . cord-348409-oxjd263z 167 1 For for IN cord-348409-oxjd263z 167 2 example example NN cord-348409-oxjd263z 167 3 as as IN cord-348409-oxjd263z 167 4 discussed discuss VBN cord-348409-oxjd263z 167 5 above above RB cord-348409-oxjd263z 167 6 , , , cord-348409-oxjd263z 167 7 despite despite IN cord-348409-oxjd263z 167 8 extensive extensive JJ cord-348409-oxjd263z 167 9 work work NN cord-348409-oxjd263z 167 10 with with IN cord-348409-oxjd263z 167 11 inoviruses inoviruse NNS cord-348409-oxjd263z 167 12 beginning begin VBG cord-348409-oxjd263z 167 13 in in IN cord-348409-oxjd263z 167 14 1993 1993 CD cord-348409-oxjd263z 167 15 by by IN cord-348409-oxjd263z 167 16 Keller Keller NNP cord-348409-oxjd263z 167 17 et et NNP cord-348409-oxjd263z 167 18 al al NNP cord-348409-oxjd263z 167 19 . . . cord-348409-oxjd263z 168 1 [ [ -LRB- cord-348409-oxjd263z 168 2 66 66 CD cord-348409-oxjd263z 168 3 ] ] -RRB- cord-348409-oxjd263z 168 4 , , , cord-348409-oxjd263z 168 5 there there EX cord-348409-oxjd263z 168 6 has have VBZ cord-348409-oxjd263z 168 7 been be VBN cord-348409-oxjd263z 168 8 very very RB cord-348409-oxjd263z 168 9 little little JJ cord-348409-oxjd263z 168 10 success success NN cord-348409-oxjd263z 168 11 developing develop VBG cord-348409-oxjd263z 168 12 a a DT cord-348409-oxjd263z 168 13 ( ( -LRB- cord-348409-oxjd263z 168 14 HIV-1 HIV-1 NNP cord-348409-oxjd263z 168 15 ) ) -RRB- cord-348409-oxjd263z 168 16 vaccine vaccine NN cord-348409-oxjd263z 168 17 [ [ -LRB- cord-348409-oxjd263z 168 18 95 95 CD cord-348409-oxjd263z 168 19 ] ] -RRB- cord-348409-oxjd263z 168 20 . . . cord-348409-oxjd263z 169 1 While while IN cord-348409-oxjd263z 169 2 four four CD cord-348409-oxjd263z 169 3 major major JJ cord-348409-oxjd263z 169 4 epitopes epitope NNS cord-348409-oxjd263z 169 5 on on IN cord-348409-oxjd263z 169 6 the the DT cord-348409-oxjd263z 169 7 HIV-1 HIV-1 NNP cord-348409-oxjd263z 169 8 envelope envelope NN cord-348409-oxjd263z 169 9 gp41 gp41 NN cord-348409-oxjd263z 169 10 and and CC cord-348409-oxjd263z 169 11 gp120 gp120 NNP cord-348409-oxjd263z 169 12 glycoproteins glycoprotein NNS cord-348409-oxjd263z 169 13 have have VBP cord-348409-oxjd263z 169 14 been be VBN cord-348409-oxjd263z 169 15 identified identify VBN cord-348409-oxjd263z 169 16 [ [ -LRB- cord-348409-oxjd263z 169 17 96 96 CD cord-348409-oxjd263z 169 18 ] ] -RRB- cord-348409-oxjd263z 169 19 [ [ -LRB- cord-348409-oxjd263z 169 20 97 97 CD cord-348409-oxjd263z 169 21 ] ] -RRB- cord-348409-oxjd263z 169 22 [ [ -LRB- cord-348409-oxjd263z 169 23 98 98 CD cord-348409-oxjd263z 169 24 ] ] -RRB- cord-348409-oxjd263z 169 25 , , , cord-348409-oxjd263z 169 26 inducing induce VBG cord-348409-oxjd263z 169 27 the the DT cord-348409-oxjd263z 169 28 production production NN cord-348409-oxjd263z 169 29 of of IN cord-348409-oxjd263z 169 30 effective effective JJ cord-348409-oxjd263z 169 31 antibodies antibody NNS cord-348409-oxjd263z 169 32 has have VBZ cord-348409-oxjd263z 169 33 not not RB cord-348409-oxjd263z 169 34 been be VBN cord-348409-oxjd263z 169 35 successful successful JJ cord-348409-oxjd263z 169 36 [ [ -LRB- cord-348409-oxjd263z 169 37 70 70 CD cord-348409-oxjd263z 169 38 ] ] -RRB- cord-348409-oxjd263z 169 39 . . . cord-348409-oxjd263z 170 1 While while IN cord-348409-oxjd263z 170 2 current current JJ cord-348409-oxjd263z 170 3 techniques technique NNS cord-348409-oxjd263z 170 4 have have VBP cord-348409-oxjd263z 170 5 not not RB cord-348409-oxjd263z 170 6 succeeded succeed VBN cord-348409-oxjd263z 170 7 , , , cord-348409-oxjd263z 170 8 both both CC cord-348409-oxjd263z 170 9 humoral humoral JJ cord-348409-oxjd263z 170 10 and and CC cord-348409-oxjd263z 170 11 cellular cellular JJ cord-348409-oxjd263z 170 12 responses response NNS cord-348409-oxjd263z 170 13 to to IN cord-348409-oxjd263z 170 14 HIV-1 HIV-1 NNP cord-348409-oxjd263z 170 15 through through IN cord-348409-oxjd263z 170 16 inovirus inovirus NNP cord-348409-oxjd263z 170 17 - - HYPH cord-348409-oxjd263z 170 18 based base VBN cord-348409-oxjd263z 170 19 vaccines vaccine NNS cord-348409-oxjd263z 170 20 are be VBP cord-348409-oxjd263z 170 21 being be VBG cord-348409-oxjd263z 170 22 researched research VBN cord-348409-oxjd263z 170 23 [ [ -LRB- cord-348409-oxjd263z 170 24 99 99 CD cord-348409-oxjd263z 170 25 , , , cord-348409-oxjd263z 170 26 100 100 CD cord-348409-oxjd263z 170 27 ] ] -RRB- cord-348409-oxjd263z 170 28 . . . cord-348409-oxjd263z 171 1 However however RB cord-348409-oxjd263z 171 2 , , , cord-348409-oxjd263z 171 3 the the DT cord-348409-oxjd263z 171 4 groundwork groundwork NN cord-348409-oxjd263z 171 5 for for IN cord-348409-oxjd263z 171 6 future future JJ cord-348409-oxjd263z 171 7 work work NN cord-348409-oxjd263z 171 8 involving involve VBG cord-348409-oxjd263z 171 9 HIV-1 HIV-1 NNP cord-348409-oxjd263z 171 10 and and CC cord-348409-oxjd263z 171 11 other other JJ cord-348409-oxjd263z 171 12 diseases disease NNS cord-348409-oxjd263z 171 13 has have VBZ cord-348409-oxjd263z 171 14 been be VBN cord-348409-oxjd263z 171 15 laid lay VBN cord-348409-oxjd263z 171 16 out out RP cord-348409-oxjd263z 171 17 , , , cord-348409-oxjd263z 171 18 paving pave VBG cord-348409-oxjd263z 171 19 the the DT cord-348409-oxjd263z 171 20 way way NN cord-348409-oxjd263z 171 21 for for IN cord-348409-oxjd263z 171 22 a a DT cord-348409-oxjd263z 171 23 multitude multitude NN cord-348409-oxjd263z 171 24 of of IN cord-348409-oxjd263z 171 25 various various JJ cord-348409-oxjd263z 171 26 new new JJ cord-348409-oxjd263z 171 27 inovirus inovirus NNP cord-348409-oxjd263z 171 28 - - HYPH cord-348409-oxjd263z 171 29 based base VBN cord-348409-oxjd263z 171 30 vaccines vaccine NNS cord-348409-oxjd263z 171 31 . . . cord-348409-oxjd263z 172 1 While while IN cord-348409-oxjd263z 172 2 there there EX cord-348409-oxjd263z 172 3 have have VBP cord-348409-oxjd263z 172 4 been be VBN cord-348409-oxjd263z 172 5 many many JJ cord-348409-oxjd263z 172 6 vaccine vaccine NN cord-348409-oxjd263z 172 7 studies study NNS cord-348409-oxjd263z 172 8 targeting target VBG cord-348409-oxjd263z 172 9 HIV-1 HIV-1 NNP cord-348409-oxjd263z 172 10 using use VBG cord-348409-oxjd263z 172 11 IAVs iav NNS cord-348409-oxjd263z 172 12 , , , cord-348409-oxjd263z 172 13 none none NN cord-348409-oxjd263z 172 14 have have VBP cord-348409-oxjd263z 172 15 been be VBN cord-348409-oxjd263z 172 16 completely completely RB cord-348409-oxjd263z 172 17 successful successful JJ cord-348409-oxjd263z 172 18 . . . cord-348409-oxjd263z 173 1 Studies study NNS cord-348409-oxjd263z 173 2 involving involve VBG cord-348409-oxjd263z 173 3 inovirus inovirus NNP cord-348409-oxjd263z 173 4 based base VBN cord-348409-oxjd263z 173 5 - - : cord-348409-oxjd263z 173 6 vaccines vaccine NNS cord-348409-oxjd263z 173 7 targeting target VBG cord-348409-oxjd263z 173 8 HIV-1 HIV-1 NNP cord-348409-oxjd263z 173 9 initially initially RB cord-348409-oxjd263z 173 10 only only RB cord-348409-oxjd263z 173 11 used use VBD cord-348409-oxjd263z 173 12 the the DT cord-348409-oxjd263z 173 13 broadly broadly RB cord-348409-oxjd263z 173 14 neutralizing neutralize VBG cord-348409-oxjd263z 173 15 monoclonal monoclonal JJ cord-348409-oxjd263z 173 16 antibodies antibody NNS cord-348409-oxjd263z 173 17 2F5 2f5 CD cord-348409-oxjd263z 173 18 , , , cord-348409-oxjd263z 173 19 2G12 2g12 CD cord-348409-oxjd263z 173 20 and and CC cord-348409-oxjd263z 173 21 b12 b12 NN cord-348409-oxjd263z 173 22 [ [ -LRB- cord-348409-oxjd263z 173 23 55 55 CD cord-348409-oxjd263z 173 24 , , , cord-348409-oxjd263z 173 25 [ [ -LRB- cord-348409-oxjd263z 173 26 66 66 CD cord-348409-oxjd263z 173 27 ] ] -RRB- cord-348409-oxjd263z 174 1 [ [ -LRB- cord-348409-oxjd263z 174 2 67 67 CD cord-348409-oxjd263z 174 3 ] ] -RRB- cord-348409-oxjd263z 175 1 [ [ -LRB- cord-348409-oxjd263z 175 2 68 68 CD cord-348409-oxjd263z 175 3 ] ] -RRB- cord-348409-oxjd263z 175 4 [ [ -LRB- cord-348409-oxjd263z 175 5 69 69 CD cord-348409-oxjd263z 175 6 ] ] -RRB- cord-348409-oxjd263z 175 7 [ [ -LRB- cord-348409-oxjd263z 175 8 70 70 CD cord-348409-oxjd263z 175 9 ] ] -RRB- cord-348409-oxjd263z 175 10 . . . cord-348409-oxjd263z 176 1 However however RB cord-348409-oxjd263z 176 2 , , , cord-348409-oxjd263z 176 3 as as IN cord-348409-oxjd263z 176 4 discussed discuss VBN cord-348409-oxjd263z 176 5 above above RB cord-348409-oxjd263z 176 6 , , , cord-348409-oxjd263z 176 7 these these DT cord-348409-oxjd263z 176 8 studies study NNS cord-348409-oxjd263z 176 9 have have VBP cord-348409-oxjd263z 176 10 either either CC cord-348409-oxjd263z 176 11 failed fail VBN cord-348409-oxjd263z 176 12 to to TO cord-348409-oxjd263z 176 13 induce induce VB cord-348409-oxjd263z 176 14 antibodies antibody NNS cord-348409-oxjd263z 176 15 or or CC cord-348409-oxjd263z 176 16 induced induce VBN cord-348409-oxjd263z 176 17 non non JJ cord-348409-oxjd263z 176 18 - - JJ cord-348409-oxjd263z 176 19 neutralizing neutralize VBG cord-348409-oxjd263z 176 20 antibodies antibody NNS cord-348409-oxjd263z 176 21 , , , cord-348409-oxjd263z 176 22 despite despite IN cord-348409-oxjd263z 176 23 often often RB cord-348409-oxjd263z 176 24 inducing induce VBG cord-348409-oxjd263z 176 25 a a DT cord-348409-oxjd263z 176 26 humoral humoral JJ cord-348409-oxjd263z 176 27 response response NN cord-348409-oxjd263z 176 28 . . . cord-348409-oxjd263z 177 1 In in IN cord-348409-oxjd263z 177 2 other other JJ cord-348409-oxjd263z 177 3 studies study NNS cord-348409-oxjd263z 177 4 , , , cord-348409-oxjd263z 177 5 polyclonal polyclonal JJ cord-348409-oxjd263z 177 6 sera sera NNP cord-348409-oxjd263z 177 7 from from IN cord-348409-oxjd263z 177 8 HIV-1-infected hiv-1-infecte VBN cord-348409-oxjd263z 177 9 individuals individual NNS cord-348409-oxjd263z 177 10 have have VBP cord-348409-oxjd263z 177 11 been be VBN cord-348409-oxjd263z 177 12 used use VBN cord-348409-oxjd263z 177 13 to to TO cord-348409-oxjd263z 177 14 screen screen NN cord-348409-oxjd263z 177 15 RPLs rpl NNS cord-348409-oxjd263z 177 16 to to TO cord-348409-oxjd263z 177 17 search search VB cord-348409-oxjd263z 177 18 for for IN cord-348409-oxjd263z 177 19 new new JJ cord-348409-oxjd263z 177 20 broadly broadly RB cord-348409-oxjd263z 177 21 neutralizing neutralize VBG cord-348409-oxjd263z 177 22 monoclonal monoclonal JJ cord-348409-oxjd263z 177 23 anti anti JJ cord-348409-oxjd263z 177 24 - - JJ cord-348409-oxjd263z 177 25 HIV-1 hiv-1 JJ cord-348409-oxjd263z 177 26 antibodies antibody NNS cord-348409-oxjd263z 177 27 [ [ -LRB- cord-348409-oxjd263z 177 28 71 71 CD cord-348409-oxjd263z 177 29 ] ] -RRB- cord-348409-oxjd263z 177 30 [ [ -LRB- cord-348409-oxjd263z 177 31 72 72 CD cord-348409-oxjd263z 177 32 ] ] -RRB- cord-348409-oxjd263z 177 33 [ [ -LRB- cord-348409-oxjd263z 177 34 73 73 CD cord-348409-oxjd263z 177 35 ] ] -RRB- cord-348409-oxjd263z 177 36 [ [ -LRB- cord-348409-oxjd263z 177 37 74 74 CD cord-348409-oxjd263z 177 38 ] ] -RRB- cord-348409-oxjd263z 178 1 [ [ -LRB- cord-348409-oxjd263z 178 2 75 75 CD cord-348409-oxjd263z 178 3 ] ] -RRB- cord-348409-oxjd263z 178 4 101 101 CD cord-348409-oxjd263z 178 5 ] ] -RRB- cord-348409-oxjd263z 178 6 . . . cord-348409-oxjd263z 179 1 These these DT cord-348409-oxjd263z 179 2 studies study NNS cord-348409-oxjd263z 179 3 have have VBP cord-348409-oxjd263z 179 4 used use VBN cord-348409-oxjd263z 179 5 IAVs iav NNS cord-348409-oxjd263z 179 6 to to TO cord-348409-oxjd263z 179 7 induce induce VB cord-348409-oxjd263z 179 8 the the DT cord-348409-oxjd263z 179 9 protection protection NN cord-348409-oxjd263z 179 10 of of IN cord-348409-oxjd263z 179 11 neutralizing neutralize VBG cord-348409-oxjd263z 179 12 antibodies antibody NNS cord-348409-oxjd263z 179 13 in in IN cord-348409-oxjd263z 179 14 mice mouse NNS cord-348409-oxjd263z 179 15 [ [ -LRB- cord-348409-oxjd263z 179 16 73 73 CD cord-348409-oxjd263z 179 17 ] ] -RRB- cord-348409-oxjd263z 179 18 and and CC cord-348409-oxjd263z 179 19 macaques macaque NNS cord-348409-oxjd263z 179 20 ( ( -LRB- cord-348409-oxjd263z 179 21 against against IN cord-348409-oxjd263z 179 22 Simian Simian NNP cord-348409-oxjd263z 179 23 - - HYPH cord-348409-oxjd263z 179 24 Human Human NNP cord-348409-oxjd263z 179 25 Immunodeficiency Immunodeficiency NNP cord-348409-oxjd263z 179 26 Virus Virus NNP cord-348409-oxjd263z 179 27 ) ) -RRB- cord-348409-oxjd263z 179 28 [ [ -LRB- cord-348409-oxjd263z 179 29 75 75 CD cord-348409-oxjd263z 179 30 ] ] -RRB- cord-348409-oxjd263z 179 31 . . . cord-348409-oxjd263z 180 1 Inovirusbased inovirusbased JJ cord-348409-oxjd263z 180 2 vaccines vaccine NNS cord-348409-oxjd263z 180 3 targeting target VBG cord-348409-oxjd263z 180 4 HIV-1 HIV-1 NNP cord-348409-oxjd263z 180 5 have have VBP cord-348409-oxjd263z 180 6 been be VBN cord-348409-oxjd263z 180 7 able able JJ cord-348409-oxjd263z 180 8 to to TO cord-348409-oxjd263z 180 9 control control VB cord-348409-oxjd263z 180 10 viral viral JJ cord-348409-oxjd263z 180 11 load load NN cord-348409-oxjd263z 180 12 in in IN cord-348409-oxjd263z 180 13 a a DT cord-348409-oxjd263z 180 14 variety variety NN cord-348409-oxjd263z 180 15 of of IN cord-348409-oxjd263z 180 16 non non JJ cord-348409-oxjd263z 180 17 - - JJ cord-348409-oxjd263z 180 18 human human JJ cord-348409-oxjd263z 180 19 mammals mammal NNS cord-348409-oxjd263z 180 20 after after IN cord-348409-oxjd263z 180 21 a a DT cord-348409-oxjd263z 180 22 challenge challenge NN cord-348409-oxjd263z 180 23 by by IN cord-348409-oxjd263z 180 24 HIV-1 HIV-1 NNP cord-348409-oxjd263z 180 25 or or CC cord-348409-oxjd263z 180 26 induce induce VB cord-348409-oxjd263z 180 27 neutralizing neutralize VBG cord-348409-oxjd263z 180 28 antibodies antibody NNS cord-348409-oxjd263z 180 29 , , , cord-348409-oxjd263z 180 30 but but CC cord-348409-oxjd263z 180 31 not not RB cord-348409-oxjd263z 180 32 inhibit inhibit VB cord-348409-oxjd263z 180 33 novel novel JJ cord-348409-oxjd263z 180 34 infection infection NN cord-348409-oxjd263z 180 35 or or CC cord-348409-oxjd263z 180 36 induce induce VB cord-348409-oxjd263z 180 37 broadly broadly RB cord-348409-oxjd263z 180 38 neutralizing neutralize VBG cord-348409-oxjd263z 180 39 antibodies antibody NNS cord-348409-oxjd263z 180 40 . . . cord-348409-oxjd263z 181 1 Additionally additionally RB cord-348409-oxjd263z 181 2 , , , cord-348409-oxjd263z 181 3 inovirus inovirus NNP cord-348409-oxjd263z 181 4 - - HYPH cord-348409-oxjd263z 181 5 based base VBN cord-348409-oxjd263z 181 6 HIV-1 HIV-1 NNP cord-348409-oxjd263z 181 7 vaccines vaccine NNS cord-348409-oxjd263z 181 8 have have VBP cord-348409-oxjd263z 181 9 often often RB cord-348409-oxjd263z 181 10 failed fail VBN cord-348409-oxjd263z 181 11 due due IN cord-348409-oxjd263z 181 12 to to IN cord-348409-oxjd263z 181 13 the the DT cord-348409-oxjd263z 181 14 autoreactivity autoreactivity NN cord-348409-oxjd263z 181 15 of of IN cord-348409-oxjd263z 181 16 the the DT cord-348409-oxjd263z 181 17 monoclonal monoclonal JJ cord-348409-oxjd263z 181 18 antibodies antibody NNS cord-348409-oxjd263z 181 19 that that WDT cord-348409-oxjd263z 181 20 can can MD cord-348409-oxjd263z 181 21 hopefully hopefully RB cord-348409-oxjd263z 181 22 be be VB cord-348409-oxjd263z 181 23 avoided avoid VBN cord-348409-oxjd263z 181 24 with with IN cord-348409-oxjd263z 181 25 the the DT cord-348409-oxjd263z 181 26 new new JJ cord-348409-oxjd263z 181 27 ' ' `` cord-348409-oxjd263z 181 28 next next JJ cord-348409-oxjd263z 181 29 generation generation NN cord-348409-oxjd263z 181 30 ' ' '' cord-348409-oxjd263z 181 31 broadly broadly RB cord-348409-oxjd263z 181 32 neutralizing neutralize VBG cord-348409-oxjd263z 181 33 antibodies antibody NNS cord-348409-oxjd263z 181 34 [ [ -LRB- cord-348409-oxjd263z 181 35 102 102 CD cord-348409-oxjd263z 181 36 ] ] -RRB- cord-348409-oxjd263z 181 37 [ [ -LRB- cord-348409-oxjd263z 181 38 103 103 CD cord-348409-oxjd263z 181 39 ] ] -RRB- cord-348409-oxjd263z 181 40 [ [ -LRB- cord-348409-oxjd263z 181 41 104 104 CD cord-348409-oxjd263z 181 42 ] ] -RRB- cord-348409-oxjd263z 181 43 [ [ -LRB- cord-348409-oxjd263z 181 44 105 105 CD cord-348409-oxjd263z 181 45 ] ] -RRB- cord-348409-oxjd263z 181 46 [ [ -LRB- cord-348409-oxjd263z 181 47 106 106 CD cord-348409-oxjd263z 181 48 ] ] -RRB- cord-348409-oxjd263z 181 49 . . . cord-348409-oxjd263z 182 1 Inoviral Inoviral NNP cord-348409-oxjd263z 182 2 vectors vector NNS cord-348409-oxjd263z 182 3 have have VBP cord-348409-oxjd263z 182 4 been be VBN cord-348409-oxjd263z 182 5 used use VBN cord-348409-oxjd263z 182 6 extensively extensively RB cord-348409-oxjd263z 182 7 in in IN cord-348409-oxjd263z 182 8 the the DT cord-348409-oxjd263z 182 9 development development NN cord-348409-oxjd263z 182 10 of of IN cord-348409-oxjd263z 182 11 vaccines vaccine NNS cord-348409-oxjd263z 182 12 against against IN cord-348409-oxjd263z 182 13 a a DT cord-348409-oxjd263z 182 14 variety variety NN cord-348409-oxjd263z 182 15 of of IN cord-348409-oxjd263z 182 16 infectious infectious JJ cord-348409-oxjd263z 182 17 and and CC cord-348409-oxjd263z 182 18 noninfectious noninfectious JJ cord-348409-oxjd263z 182 19 diseases disease NNS cord-348409-oxjd263z 182 20 over over IN cord-348409-oxjd263z 182 21 the the DT cord-348409-oxjd263z 182 22 past past JJ cord-348409-oxjd263z 182 23 two two CD cord-348409-oxjd263z 182 24 decades decade NNS cord-348409-oxjd263z 182 25 . . . cord-348409-oxjd263z 183 1 As as IN cord-348409-oxjd263z 183 2 shown show VBN cord-348409-oxjd263z 183 3 above above RB cord-348409-oxjd263z 183 4 , , , cord-348409-oxjd263z 183 5 the the DT cord-348409-oxjd263z 183 6 IAVs iav NNS cord-348409-oxjd263z 183 7 have have VBP cord-348409-oxjd263z 183 8 successfully successfully RB cord-348409-oxjd263z 183 9 induced induce VBN cord-348409-oxjd263z 183 10 a a DT cord-348409-oxjd263z 183 11 humoral humoral JJ cord-348409-oxjd263z 183 12 or or CC cord-348409-oxjd263z 183 13 cellular cellular JJ cord-348409-oxjd263z 183 14 response response NN cord-348409-oxjd263z 183 15 , , , cord-348409-oxjd263z 183 16 or or CC cord-348409-oxjd263z 183 17 both both DT cord-348409-oxjd263z 183 18 . . . cord-348409-oxjd263z 184 1 In in IN cord-348409-oxjd263z 184 2 the the DT cord-348409-oxjd263z 184 3 studies study NNS cord-348409-oxjd263z 184 4 , , , cord-348409-oxjd263z 184 5 the the DT cord-348409-oxjd263z 184 6 vaccines vaccine NNS cord-348409-oxjd263z 184 7 could could MD cord-348409-oxjd263z 184 8 provide provide VB cord-348409-oxjd263z 184 9 partial partial JJ cord-348409-oxjd263z 184 10 or or CC cord-348409-oxjd263z 184 11 complete complete JJ cord-348409-oxjd263z 184 12 protection protection NN cord-348409-oxjd263z 184 13 against against IN cord-348409-oxjd263z 184 14 pathogens pathogen NNS cord-348409-oxjd263z 184 15 causing cause VBG cord-348409-oxjd263z 184 16 infectious infectious JJ cord-348409-oxjd263z 184 17 disease disease NN cord-348409-oxjd263z 184 18 or or CC cord-348409-oxjd263z 184 19 merely merely RB cord-348409-oxjd263z 184 20 lower lower VB cord-348409-oxjd263z 184 21 the the DT cord-348409-oxjd263z 184 22 burden burden NN cord-348409-oxjd263z 184 23 of of IN cord-348409-oxjd263z 184 24 infection infection NN cord-348409-oxjd263z 184 25 . . . cord-348409-oxjd263z 185 1 Against against IN cord-348409-oxjd263z 185 2 non non JJ cord-348409-oxjd263z 185 3 - - JJ cord-348409-oxjd263z 185 4 infectious infectious JJ cord-348409-oxjd263z 185 5 diseases disease NNS cord-348409-oxjd263z 185 6 , , , cord-348409-oxjd263z 185 7 inovirus inovirus NNP cord-348409-oxjd263z 185 8 - - HYPH cord-348409-oxjd263z 185 9 based base VBN cord-348409-oxjd263z 185 10 vaccines vaccine NNS cord-348409-oxjd263z 185 11 have have VBP cord-348409-oxjd263z 185 12 been be VBN cord-348409-oxjd263z 185 13 shown show VBN cord-348409-oxjd263z 185 14 to to TO cord-348409-oxjd263z 185 15 be be VB cord-348409-oxjd263z 185 16 effective effective JJ cord-348409-oxjd263z 185 17 at at IN cord-348409-oxjd263z 185 18 mitigating mitigate VBG cord-348409-oxjd263z 185 19 disease disease NN cord-348409-oxjd263z 185 20 development development NN cord-348409-oxjd263z 185 21 by by IN cord-348409-oxjd263z 185 22 initiating initiate VBG cord-348409-oxjd263z 185 23 productive productive JJ cord-348409-oxjd263z 185 24 immune immune JJ cord-348409-oxjd263z 185 25 responses response NNS cord-348409-oxjd263z 185 26 . . . cord-348409-oxjd263z 186 1 There there EX cord-348409-oxjd263z 186 2 have have VBP cord-348409-oxjd263z 186 3 already already RB cord-348409-oxjd263z 186 4 been be VBN cord-348409-oxjd263z 186 5 many many JJ cord-348409-oxjd263z 186 6 applications application NNS cord-348409-oxjd263z 186 7 of of IN cord-348409-oxjd263z 186 8 vaccines vaccine NNS cord-348409-oxjd263z 186 9 against against IN cord-348409-oxjd263z 186 10 infectious infectious JJ cord-348409-oxjd263z 186 11 and and CC cord-348409-oxjd263z 186 12 non non JJ cord-348409-oxjd263z 186 13 - - JJ cord-348409-oxjd263z 186 14 infectious infectious JJ cord-348409-oxjd263z 186 15 diseases disease NNS cord-348409-oxjd263z 186 16 using use VBG cord-348409-oxjd263z 186 17 inoviral inoviral NN cord-348409-oxjd263z 186 18 vectors vector NNS cord-348409-oxjd263z 186 19 and and CC cord-348409-oxjd263z 186 20 IAVs iav NNS cord-348409-oxjd263z 186 21 have have VBP cord-348409-oxjd263z 186 22 distinct distinct JJ cord-348409-oxjd263z 186 23 characteristics characteristic NNS cord-348409-oxjd263z 186 24 that that WDT cord-348409-oxjd263z 186 25 make make VBP cord-348409-oxjd263z 186 26 them -PRON- PRP cord-348409-oxjd263z 186 27 more more RBR cord-348409-oxjd263z 186 28 applicable applicable JJ cord-348409-oxjd263z 186 29 for for IN cord-348409-oxjd263z 186 30 the the DT cord-348409-oxjd263z 186 31 development development NN cord-348409-oxjd263z 186 32 of of IN cord-348409-oxjd263z 186 33 new new JJ cord-348409-oxjd263z 186 34 vaccines vaccine NNS cord-348409-oxjd263z 186 35 than than IN cord-348409-oxjd263z 186 36 other other JJ cord-348409-oxjd263z 186 37 viral viral JJ cord-348409-oxjd263z 186 38 vectors vector NNS cord-348409-oxjd263z 186 39 . . . cord-348409-oxjd263z 187 1 Inoviruses Inoviruses NNP cord-348409-oxjd263z 187 2 and and CC cord-348409-oxjd263z 187 3 by by IN cord-348409-oxjd263z 187 4 extent extent NN cord-348409-oxjd263z 188 1 IAVs iav NNS cord-348409-oxjd263z 188 2 are be VBP cord-348409-oxjd263z 188 3 highly highly RB cord-348409-oxjd263z 188 4 immunogenic immunogenic JJ cord-348409-oxjd263z 188 5 and and CC cord-348409-oxjd263z 188 6 do do VBP cord-348409-oxjd263z 188 7 not not RB cord-348409-oxjd263z 188 8 require require VB cord-348409-oxjd263z 188 9 adjuvants adjuvant NNS cord-348409-oxjd263z 188 10 , , , cord-348409-oxjd263z 188 11 facilitating facilitate VBG cord-348409-oxjd263z 188 12 the the DT cord-348409-oxjd263z 188 13 ease ease NN cord-348409-oxjd263z 188 14 and and CC cord-348409-oxjd263z 188 15 simplicity simplicity NN cord-348409-oxjd263z 188 16 of of IN cord-348409-oxjd263z 188 17 usage usage NN cord-348409-oxjd263z 188 18 as as IN cord-348409-oxjd263z 188 19 vaccines vaccine NNS cord-348409-oxjd263z 188 20 . . . cord-348409-oxjd263z 189 1 They -PRON- PRP cord-348409-oxjd263z 189 2 can can MD cord-348409-oxjd263z 189 3 display display VB cord-348409-oxjd263z 189 4 multiple multiple JJ cord-348409-oxjd263z 189 5 ( ( -LRB- cord-348409-oxjd263z 189 6 from from IN cord-348409-oxjd263z 189 7 few few JJ cord-348409-oxjd263z 189 8 to to IN cord-348409-oxjd263z 189 9 thousands thousand NNS cord-348409-oxjd263z 189 10 ) ) -RRB- cord-348409-oxjd263z 189 11 copies copy NNS cord-348409-oxjd263z 189 12 of of IN cord-348409-oxjd263z 189 13 a a DT cord-348409-oxjd263z 189 14 peptide peptide NN cord-348409-oxjd263z 189 15 on on IN cord-348409-oxjd263z 189 16 their -PRON- PRP$ cord-348409-oxjd263z 189 17 surface surface NN cord-348409-oxjd263z 189 18 while while IN cord-348409-oxjd263z 189 19 still still RB cord-348409-oxjd263z 189 20 maintaining maintain VBG cord-348409-oxjd263z 189 21 the the DT cord-348409-oxjd263z 189 22 desired desire VBN cord-348409-oxjd263z 189 23 structure structure NN cord-348409-oxjd263z 189 24 and and CC cord-348409-oxjd263z 189 25 conformation conformation NN cord-348409-oxjd263z 189 26 as as RB cord-348409-oxjd263z 189 27 well well RB cord-348409-oxjd263z 189 28 as as IN cord-348409-oxjd263z 189 29 infectivity infectivity NN cord-348409-oxjd263z 189 30 with with IN cord-348409-oxjd263z 189 31 their -PRON- PRP$ cord-348409-oxjd263z 189 32 bacterial bacterial JJ cord-348409-oxjd263z 189 33 hosts host NNS cord-348409-oxjd263z 189 34 . . . cord-348409-oxjd263z 190 1 IAVs IAVs NNP cord-348409-oxjd263z 190 2 , , , cord-348409-oxjd263z 190 3 by by IN cord-348409-oxjd263z 190 4 displaying display VBG cord-348409-oxjd263z 190 5 only only RB cord-348409-oxjd263z 190 6 particular particular JJ cord-348409-oxjd263z 190 7 peptides peptide NNS cord-348409-oxjd263z 190 8 , , , cord-348409-oxjd263z 190 9 allow allow VB cord-348409-oxjd263z 190 10 the the DT cord-348409-oxjd263z 190 11 immune immune JJ cord-348409-oxjd263z 190 12 system system NN cord-348409-oxjd263z 190 13 to to TO cord-348409-oxjd263z 190 14 interact interact VB cord-348409-oxjd263z 190 15 with with IN cord-348409-oxjd263z 190 16 a a DT cord-348409-oxjd263z 190 17 specific specific JJ cord-348409-oxjd263z 190 18 epitope epitope NN cord-348409-oxjd263z 190 19 rather rather RB cord-348409-oxjd263z 190 20 than than IN cord-348409-oxjd263z 190 21 a a DT cord-348409-oxjd263z 190 22 larger large JJR cord-348409-oxjd263z 190 23 , , , cord-348409-oxjd263z 190 24 more more RBR cord-348409-oxjd263z 190 25 complex complex JJ cord-348409-oxjd263z 190 26 protein protein NN cord-348409-oxjd263z 190 27 , , , cord-348409-oxjd263z 190 28 yielding yield VBG cord-348409-oxjd263z 190 29 a a DT cord-348409-oxjd263z 190 30 more more RBR cord-348409-oxjd263z 190 31 targeted targeted JJ cord-348409-oxjd263z 190 32 response response NN cord-348409-oxjd263z 190 33 . . . cord-348409-oxjd263z 191 1 They -PRON- PRP cord-348409-oxjd263z 191 2 are be VBP cord-348409-oxjd263z 191 3 capable capable JJ cord-348409-oxjd263z 191 4 of of IN cord-348409-oxjd263z 191 5 stimulating stimulate VBG cord-348409-oxjd263z 191 6 humoral humoral JJ cord-348409-oxjd263z 191 7 and and CC cord-348409-oxjd263z 191 8 cellular cellular JJ cord-348409-oxjd263z 191 9 immune immune JJ cord-348409-oxjd263z 191 10 responses response NNS cord-348409-oxjd263z 191 11 and and CC cord-348409-oxjd263z 191 12 do do VBP cord-348409-oxjd263z 191 13 not not RB cord-348409-oxjd263z 191 14 pose pose VB cord-348409-oxjd263z 191 15 known know VBN cord-348409-oxjd263z 191 16 health health NN cord-348409-oxjd263z 191 17 risks risk NNS cord-348409-oxjd263z 191 18 to to IN cord-348409-oxjd263z 191 19 animals animal NNS cord-348409-oxjd263z 191 20 or or CC cord-348409-oxjd263z 191 21 humans human NNS cord-348409-oxjd263z 191 22 . . . cord-348409-oxjd263z 192 1 IAVs iav NNS cord-348409-oxjd263z 192 2 can can MD cord-348409-oxjd263z 192 3 be be VB cord-348409-oxjd263z 192 4 administered administer VBN cord-348409-oxjd263z 192 5 safely safely RB cord-348409-oxjd263z 192 6 in in IN cord-348409-oxjd263z 192 7 high high JJ cord-348409-oxjd263z 192 8 doses dose NNS cord-348409-oxjd263z 192 9 through through IN cord-348409-oxjd263z 192 10 multiple multiple JJ cord-348409-oxjd263z 192 11 routes route NNS cord-348409-oxjd263z 192 12 , , , cord-348409-oxjd263z 192 13 enhancing enhance VBG cord-348409-oxjd263z 192 14 their -PRON- PRP$ cord-348409-oxjd263z 192 15 usage usage NN cord-348409-oxjd263z 192 16 in in IN cord-348409-oxjd263z 192 17 a a DT cord-348409-oxjd263z 192 18 variety variety NN cord-348409-oxjd263z 192 19 of of IN cord-348409-oxjd263z 192 20 contexts context NNS cord-348409-oxjd263z 192 21 [ [ -LRB- cord-348409-oxjd263z 192 22 107 107 CD cord-348409-oxjd263z 192 23 ] ] -RRB- cord-348409-oxjd263z 192 24 . . . cord-348409-oxjd263z 193 1 With with IN cord-348409-oxjd263z 193 2 their -PRON- PRP$ cord-348409-oxjd263z 193 3 cost cost NN cord-348409-oxjd263z 193 4 - - HYPH cord-348409-oxjd263z 193 5 efficient efficient JJ cord-348409-oxjd263z 193 6 production production NN cord-348409-oxjd263z 193 7 , , , cord-348409-oxjd263z 193 8 structural structural JJ cord-348409-oxjd263z 193 9 simplicity simplicity NN cord-348409-oxjd263z 193 10 , , , cord-348409-oxjd263z 193 11 and and CC cord-348409-oxjd263z 193 12 record record NN cord-348409-oxjd263z 193 13 of of IN cord-348409-oxjd263z 193 14 success success NN cord-348409-oxjd263z 193 15 in in IN cord-348409-oxjd263z 193 16 a a DT cord-348409-oxjd263z 193 17 variety variety NN cord-348409-oxjd263z 193 18 of of IN cord-348409-oxjd263z 193 19 contexts context NNS cord-348409-oxjd263z 193 20 , , , cord-348409-oxjd263z 193 21 IAVs iav NNS cord-348409-oxjd263z 193 22 have have VBP cord-348409-oxjd263z 193 23 the the DT cord-348409-oxjd263z 193 24 potential potential NN cord-348409-oxjd263z 193 25 to to TO cord-348409-oxjd263z 193 26 be be VB cord-348409-oxjd263z 193 27 exploited exploit VBN cord-348409-oxjd263z 193 28 for for IN cord-348409-oxjd263z 193 29 many many JJ cord-348409-oxjd263z 193 30 new new JJ cord-348409-oxjd263z 193 31 vaccines vaccine NNS cord-348409-oxjd263z 193 32 in in IN cord-348409-oxjd263z 193 33 humans human NNS cord-348409-oxjd263z 193 34 and and CC cord-348409-oxjd263z 193 35 animals animal NNS cord-348409-oxjd263z 193 36 against against IN cord-348409-oxjd263z 193 37 a a DT cord-348409-oxjd263z 193 38 variety variety NN cord-348409-oxjd263z 193 39 of of IN cord-348409-oxjd263z 193 40 diseases disease NNS cord-348409-oxjd263z 193 41 . . . cord-348409-oxjd263z 194 1 Advances advance NNS cord-348409-oxjd263z 194 2 in in IN cord-348409-oxjd263z 194 3 inovirus inovirus NNP cord-348409-oxjd263z 194 4 research research NN cord-348409-oxjd263z 194 5 and and CC cord-348409-oxjd263z 194 6 phage phage NN cord-348409-oxjd263z 194 7 display display NN cord-348409-oxjd263z 194 8 technology technology NN cord-348409-oxjd263z 194 9 are be VBP cord-348409-oxjd263z 194 10 making make VBG cord-348409-oxjd263z 194 11 the the DT cord-348409-oxjd263z 194 12 development development NN cord-348409-oxjd263z 194 13 of of IN cord-348409-oxjd263z 194 14 new new JJ cord-348409-oxjd263z 194 15 vaccines vaccine NNS cord-348409-oxjd263z 194 16 for for IN cord-348409-oxjd263z 194 17 a a DT cord-348409-oxjd263z 194 18 variety variety NN cord-348409-oxjd263z 194 19 of of IN cord-348409-oxjd263z 194 20 diseases disease NNS cord-348409-oxjd263z 194 21 feasible feasible JJ cord-348409-oxjd263z 194 22 in in IN cord-348409-oxjd263z 194 23 the the DT cord-348409-oxjd263z 194 24 near near JJ cord-348409-oxjd263z 194 25 future future NN cord-348409-oxjd263z 194 26 . . . cord-348409-oxjd263z 195 1 Currently currently RB cord-348409-oxjd263z 195 2 , , , cord-348409-oxjd263z 195 3 there there EX cord-348409-oxjd263z 195 4 are be VBP cord-348409-oxjd263z 195 5 many many JJ cord-348409-oxjd263z 195 6 diseases disease NNS cord-348409-oxjd263z 195 7 without without IN cord-348409-oxjd263z 195 8 vaccines vaccine NNS cord-348409-oxjd263z 195 9 or or CC cord-348409-oxjd263z 195 10 for for IN cord-348409-oxjd263z 195 11 which which WDT cord-348409-oxjd263z 195 12 treatment treatment NN cord-348409-oxjd263z 195 13 is be VBZ cord-348409-oxjd263z 195 14 highly highly RB cord-348409-oxjd263z 195 15 invasive invasive JJ cord-348409-oxjd263z 195 16 . . . cord-348409-oxjd263z 196 1 Further further JJ cord-348409-oxjd263z 196 2 development development NN cord-348409-oxjd263z 196 3 involving involve VBG cord-348409-oxjd263z 196 4 IAVs iav NNS cord-348409-oxjd263z 196 5 will will MD cord-348409-oxjd263z 196 6 be be VB cord-348409-oxjd263z 196 7 likely likely JJ cord-348409-oxjd263z 196 8 to to TO cord-348409-oxjd263z 196 9 introduce introduce VB cord-348409-oxjd263z 196 10 more more JJR cord-348409-oxjd263z 196 11 , , , cord-348409-oxjd263z 196 12 better well JJR cord-348409-oxjd263z 196 13 , , , cord-348409-oxjd263z 196 14 and and CC cord-348409-oxjd263z 196 15 increasingly increasingly RB cord-348409-oxjd263z 196 16 cost cost NN cord-348409-oxjd263z 196 17 - - HYPH cord-348409-oxjd263z 196 18 effective effective JJ cord-348409-oxjd263z 196 19 vaccines vaccine NNS cord-348409-oxjd263z 196 20 . . . cord-348409-oxjd263z 197 1 As as IN cord-348409-oxjd263z 197 2 the the DT cord-348409-oxjd263z 197 3 structure structure NN cord-348409-oxjd263z 197 4 and and CC cord-348409-oxjd263z 197 5 tools tool NNS cord-348409-oxjd263z 197 6 for for IN cord-348409-oxjd263z 197 7 genetic genetic JJ cord-348409-oxjd263z 197 8 manipulation manipulation NN cord-348409-oxjd263z 197 9 of of IN cord-348409-oxjd263z 197 10 inoviruses inoviruse NNS cord-348409-oxjd263z 197 11 are be VBP cord-348409-oxjd263z 197 12 being be VBG cord-348409-oxjd263z 197 13 better well RBR cord-348409-oxjd263z 197 14 developed develop VBN cord-348409-oxjd263z 197 15 , , , cord-348409-oxjd263z 197 16 IAVs iav NNS cord-348409-oxjd263z 197 17 will will MD cord-348409-oxjd263z 197 18 likely likely RB cord-348409-oxjd263z 197 19 begin begin VB cord-348409-oxjd263z 197 20 to to TO cord-348409-oxjd263z 197 21 be be VB cord-348409-oxjd263z 197 22 more more RBR cord-348409-oxjd263z 197 23 extensively extensively RB cord-348409-oxjd263z 197 24 introduced introduce VBN cord-348409-oxjd263z 197 25 into into IN cord-348409-oxjd263z 197 26 animal animal NN cord-348409-oxjd263z 197 27 and and CC cord-348409-oxjd263z 197 28 human human JJ cord-348409-oxjd263z 197 29 use use NN cord-348409-oxjd263z 197 30 . . . cord-348409-oxjd263z 198 1 The the DT cord-348409-oxjd263z 198 2 current current JJ cord-348409-oxjd263z 198 3 research research NN cord-348409-oxjd263z 198 4 is be VBZ cord-348409-oxjd263z 198 5 only only RB cord-348409-oxjd263z 198 6 revealing reveal VBG cord-348409-oxjd263z 198 7 the the DT cord-348409-oxjd263z 198 8 tip tip NN cord-348409-oxjd263z 198 9 of of IN cord-348409-oxjd263z 198 10 the the DT cord-348409-oxjd263z 198 11 iceberg iceberg NN cord-348409-oxjd263z 198 12 of of IN cord-348409-oxjd263z 198 13 the the DT cord-348409-oxjd263z 198 14 extensive extensive JJ cord-348409-oxjd263z 198 15 ways way NNS cord-348409-oxjd263z 198 16 in in IN cord-348409-oxjd263z 198 17 which which WDT cord-348409-oxjd263z 198 18 inovirus inovirus NNP cord-348409-oxjd263z 198 19 - - HYPH cord-348409-oxjd263z 198 20 based base VBN cord-348409-oxjd263z 198 21 vaccines vaccine NNS cord-348409-oxjd263z 198 22 will will MD cord-348409-oxjd263z 198 23 be be VB cord-348409-oxjd263z 198 24 applied apply VBN cord-348409-oxjd263z 198 25 in in IN cord-348409-oxjd263z 198 26 future future JJ cord-348409-oxjd263z 198 27 use use NN cord-348409-oxjd263z 198 28 . . . cord-348409-oxjd263z 199 1 Accordingly accordingly RB cord-348409-oxjd263z 199 2 , , , cord-348409-oxjd263z 199 3 there there EX cord-348409-oxjd263z 199 4 are be VBP cord-348409-oxjd263z 199 5 aspects aspect NNS cord-348409-oxjd263z 199 6 of of IN cord-348409-oxjd263z 199 7 the the DT cord-348409-oxjd263z 199 8 genetic genetic JJ cord-348409-oxjd263z 199 9 engineering engineering NN cord-348409-oxjd263z 199 10 of of IN cord-348409-oxjd263z 199 11 phage phage NN cord-348409-oxjd263z 199 12 - - HYPH cord-348409-oxjd263z 199 13 display display NN cord-348409-oxjd263z 199 14 that that WDT cord-348409-oxjd263z 199 15 need need VBP cord-348409-oxjd263z 199 16 to to TO cord-348409-oxjd263z 199 17 be be VB cord-348409-oxjd263z 199 18 further further RB cord-348409-oxjd263z 199 19 expanded expand VBN cord-348409-oxjd263z 199 20 . . . cord-348409-oxjd263z 200 1 Specifically specifically RB cord-348409-oxjd263z 200 2 , , , cord-348409-oxjd263z 200 3 further further JJ cord-348409-oxjd263z 200 4 studies study NNS cord-348409-oxjd263z 200 5 should should MD cord-348409-oxjd263z 200 6 be be VB cord-348409-oxjd263z 200 7 conducted conduct VBN cord-348409-oxjd263z 200 8 to to TO cord-348409-oxjd263z 200 9 evaluate evaluate VB cord-348409-oxjd263z 200 10 the the DT cord-348409-oxjd263z 200 11 maximum maximum JJ cord-348409-oxjd263z 200 12 antigenic antigenic JJ cord-348409-oxjd263z 200 13 load load NN cord-348409-oxjd263z 200 14 capacity capacity NN cord-348409-oxjd263z 200 15 of of IN cord-348409-oxjd263z 200 16 the the DT cord-348409-oxjd263z 200 17 gp8 gp8 NNP cord-348409-oxjd263z 200 18 coat coat NN cord-348409-oxjd263z 200 19 protein protein NN cord-348409-oxjd263z 200 20 without without IN cord-348409-oxjd263z 200 21 jeopardizing jeopardize VBG cord-348409-oxjd263z 200 22 the the DT cord-348409-oxjd263z 200 23 architectural architectural JJ cord-348409-oxjd263z 200 24 integrity integrity NN cord-348409-oxjd263z 200 25 and and CC cord-348409-oxjd263z 200 26 infectivity infectivity NN cord-348409-oxjd263z 200 27 of of IN cord-348409-oxjd263z 200 28 the the DT cord-348409-oxjd263z 200 29 IAV IAV NNP cord-348409-oxjd263z 200 30 ( ( -LRB- cord-348409-oxjd263z 200 31 Ff.g8 Ff.g8 NNP cord-348409-oxjd263z 200 32 , , , cord-348409-oxjd263z 200 33 see see VB cord-348409-oxjd263z 200 34 Figure figure NN cord-348409-oxjd263z 200 35 1 1 CD cord-348409-oxjd263z 200 36 ) ) -RRB- cord-348409-oxjd263z 200 37 . . . cord-348409-oxjd263z 201 1 Furthermore furthermore RB cord-348409-oxjd263z 201 2 , , , cord-348409-oxjd263z 201 3 additional additional JJ cord-348409-oxjd263z 201 4 research research NN cord-348409-oxjd263z 201 5 about about IN cord-348409-oxjd263z 201 6 the the DT cord-348409-oxjd263z 201 7 potential potential NN cord-348409-oxjd263z 201 8 of of IN cord-348409-oxjd263z 201 9 using use VBG cord-348409-oxjd263z 201 10 the the DT cord-348409-oxjd263z 201 11 other other JJ cord-348409-oxjd263z 201 12 capsid capsid NN cord-348409-oxjd263z 201 13 proteins protein NNS cord-348409-oxjd263z 201 14 ( ( -LRB- cord-348409-oxjd263z 201 15 gp3 gp3 NNP cord-348409-oxjd263z 201 16 , , , cord-348409-oxjd263z 201 17 gp6 gp6 NNP cord-348409-oxjd263z 201 18 , , , cord-348409-oxjd263z 201 19 gp7 gp7 NNP cord-348409-oxjd263z 201 20 , , , cord-348409-oxjd263z 201 21 and and CC cord-348409-oxjd263z 201 22 gp9 gp9 JJ cord-348409-oxjd263z 201 23 ) ) -RRB- cord-348409-oxjd263z 201 24 or or CC cord-348409-oxjd263z 201 25 combinations combination NNS cord-348409-oxjd263z 201 26 of of IN cord-348409-oxjd263z 201 27 any any DT cord-348409-oxjd263z 201 28 of of IN cord-348409-oxjd263z 201 29 the the DT cord-348409-oxjd263z 201 30 capsid capsid NN cord-348409-oxjd263z 201 31 proteins protein NNS cord-348409-oxjd263z 201 32 for for IN cord-348409-oxjd263z 201 33 antigen antigen NN cord-348409-oxjd263z 201 34 display display NN cord-348409-oxjd263z 201 35 is be VBZ cord-348409-oxjd263z 201 36 needed need VBN cord-348409-oxjd263z 201 37 . . . cord-348409-oxjd263z 202 1 Additionally additionally RB cord-348409-oxjd263z 202 2 , , , cord-348409-oxjd263z 202 3 future future JJ cord-348409-oxjd263z 202 4 studies study NNS cord-348409-oxjd263z 202 5 could could MD cord-348409-oxjd263z 202 6 elucidate elucidate VB cord-348409-oxjd263z 202 7 the the DT cord-348409-oxjd263z 202 8 nuances nuance NNS cord-348409-oxjd263z 202 9 of of IN cord-348409-oxjd263z 202 10 the the DT cord-348409-oxjd263z 202 11 uses use NNS cord-348409-oxjd263z 202 12 of of IN cord-348409-oxjd263z 202 13 individual individual JJ cord-348409-oxjd263z 202 14 capsid capsid NN cord-348409-oxjd263z 202 15 proteins protein NNS cord-348409-oxjd263z 202 16 for for IN cord-348409-oxjd263z 202 17 specialized specialized JJ cord-348409-oxjd263z 202 18 applications application NNS cord-348409-oxjd263z 202 19 such such JJ cord-348409-oxjd263z 202 20 as as IN cord-348409-oxjd263z 202 21 antigen antigen NN cord-348409-oxjd263z 202 22 display display NN cord-348409-oxjd263z 202 23 , , , cord-348409-oxjd263z 202 24 penetration penetration NN cord-348409-oxjd263z 202 25 , , , cord-348409-oxjd263z 202 26 targeting targeting NN cord-348409-oxjd263z 202 27 , , , cord-348409-oxjd263z 202 28 etc etc FW cord-348409-oxjd263z 202 29 . . . cord-348409-oxjd263z 203 1 An an DT cord-348409-oxjd263z 203 2 additional additional JJ cord-348409-oxjd263z 203 3 aspect aspect NN cord-348409-oxjd263z 203 4 of of IN cord-348409-oxjd263z 203 5 IAVs iav NNS cord-348409-oxjd263z 203 6 that that WDT cord-348409-oxjd263z 203 7 needs need VBZ cord-348409-oxjd263z 203 8 to to TO cord-348409-oxjd263z 203 9 be be VB cord-348409-oxjd263z 203 10 further further RB cord-348409-oxjd263z 203 11 explored explore VBN cord-348409-oxjd263z 203 12 is be VBZ cord-348409-oxjd263z 203 13 how how WRB cord-348409-oxjd263z 203 14 antigenic antigenic JJ cord-348409-oxjd263z 203 15 display display NN cord-348409-oxjd263z 203 16 on on IN cord-348409-oxjd263z 203 17 the the DT cord-348409-oxjd263z 203 18 surface surface NN cord-348409-oxjd263z 203 19 of of IN cord-348409-oxjd263z 203 20 IAVs iav NNS cord-348409-oxjd263z 203 21 induces induce VBZ cord-348409-oxjd263z 203 22 immunogenicity immunogenicity NN cord-348409-oxjd263z 203 23 . . . cord-348409-oxjd263z 204 1 This this DT cord-348409-oxjd263z 204 2 predictive predictive JJ cord-348409-oxjd263z 204 3 work work NN cord-348409-oxjd263z 204 4 needs need VBZ cord-348409-oxjd263z 204 5 to to TO cord-348409-oxjd263z 204 6 be be VB cord-348409-oxjd263z 204 7 undertaken undertake VBN cord-348409-oxjd263z 204 8 by by IN cord-348409-oxjd263z 204 9 experimental experimental JJ cord-348409-oxjd263z 204 10 and and CC cord-348409-oxjd263z 204 11 computational computational JJ cord-348409-oxjd263z 204 12 ( ( -LRB- cord-348409-oxjd263z 204 13 in in IN cord-348409-oxjd263z 204 14 silico silico NN cord-348409-oxjd263z 204 15 ) ) -RRB- cord-348409-oxjd263z 204 16 research research NN cord-348409-oxjd263z 204 17 . . . cord-348409-oxjd263z 205 1 Further further JJ cord-348409-oxjd263z 205 2 research research NN cord-348409-oxjd263z 205 3 will will MD cord-348409-oxjd263z 205 4 involve involve VB cord-348409-oxjd263z 205 5 the the DT cord-348409-oxjd263z 205 6 development development NN cord-348409-oxjd263z 205 7 of of IN cord-348409-oxjd263z 205 8 new new JJ cord-348409-oxjd263z 205 9 vaccines vaccine NNS cord-348409-oxjd263z 205 10 and and CC cord-348409-oxjd263z 205 11 improving improve VBG cord-348409-oxjd263z 205 12 the the DT cord-348409-oxjd263z 205 13 efficacy efficacy NN cord-348409-oxjd263z 205 14 of of IN cord-348409-oxjd263z 205 15 current current JJ cord-348409-oxjd263z 205 16 vaccines vaccine NNS cord-348409-oxjd263z 205 17 . . . cord-348409-oxjd263z 206 1 Additional additional JJ cord-348409-oxjd263z 206 2 undertakings undertaking NNS cord-348409-oxjd263z 206 3 should should MD cord-348409-oxjd263z 206 4 be be VB cord-348409-oxjd263z 206 5 done do VBN cord-348409-oxjd263z 206 6 into into IN cord-348409-oxjd263z 206 7 identifying identify VBG cord-348409-oxjd263z 206 8 the the DT cord-348409-oxjd263z 206 9 structure structure NN cord-348409-oxjd263z 206 10 of of IN cord-348409-oxjd263z 206 11 the the DT cord-348409-oxjd263z 206 12 viruses virus NNS cord-348409-oxjd263z 206 13 , , , cord-348409-oxjd263z 206 14 since since IN cord-348409-oxjd263z 206 15 this this DT cord-348409-oxjd263z 206 16 will will MD cord-348409-oxjd263z 206 17 better better RB cord-348409-oxjd263z 206 18 be be VB cord-348409-oxjd263z 206 19 able able JJ cord-348409-oxjd263z 206 20 to to TO cord-348409-oxjd263z 206 21 inform inform VB cord-348409-oxjd263z 206 22 how how WRB cord-348409-oxjd263z 206 23 the the DT cord-348409-oxjd263z 206 24 phage phage NN cord-348409-oxjd263z 206 25 - - HYPH cord-348409-oxjd263z 206 26 display display NN cord-348409-oxjd263z 206 27 technology technology NN cord-348409-oxjd263z 206 28 will will MD cord-348409-oxjd263z 206 29 best best RB cord-348409-oxjd263z 206 30 be be VB cord-348409-oxjd263z 206 31 applied apply VBN cord-348409-oxjd263z 206 32 as as IN cord-348409-oxjd263z 206 33 more more RBR cord-348409-oxjd263z 206 34 complex complex JJ cord-348409-oxjd263z 206 35 work work NN cord-348409-oxjd263z 206 36 is be VBZ cord-348409-oxjd263z 206 37 being be VBG cord-348409-oxjd263z 206 38 done do VBN cord-348409-oxjd263z 206 39 using use VBG cord-348409-oxjd263z 206 40 monoclonal monoclonal JJ cord-348409-oxjd263z 206 41 and and CC cord-348409-oxjd263z 206 42 polyclonal polyclonal JJ cord-348409-oxjd263z 206 43 antibodies antibody NNS cord-348409-oxjd263z 206 44 to to TO cord-348409-oxjd263z 206 45 create create VB cord-348409-oxjd263z 206 46 more more RBR cord-348409-oxjd263z 206 47 nuanced nuanced JJ cord-348409-oxjd263z 206 48 vaccines vaccine NNS cord-348409-oxjd263z 206 49 . . . cord-348409-oxjd263z 207 1 The the DT cord-348409-oxjd263z 207 2 future future NN cord-348409-oxjd263z 207 3 has have VBZ cord-348409-oxjd263z 207 4 a a DT cord-348409-oxjd263z 207 5 dual dual JJ cord-348409-oxjd263z 207 6 focus focus NN cord-348409-oxjd263z 207 7 : : : cord-348409-oxjd263z 207 8 the the DT cord-348409-oxjd263z 207 9 development development NN cord-348409-oxjd263z 207 10 of of IN cord-348409-oxjd263z 207 11 vaccines vaccine NNS cord-348409-oxjd263z 207 12 for for IN cord-348409-oxjd263z 207 13 infectious infectious JJ cord-348409-oxjd263z 207 14 diseases disease NNS cord-348409-oxjd263z 207 15 and and CC cord-348409-oxjd263z 207 16 the the DT cord-348409-oxjd263z 207 17 induction induction NN cord-348409-oxjd263z 207 18 of of IN cord-348409-oxjd263z 207 19 immune immune JJ cord-348409-oxjd263z 207 20 responses response NNS cord-348409-oxjd263z 207 21 in in IN cord-348409-oxjd263z 207 22 non non JJ cord-348409-oxjd263z 207 23 - - JJ cord-348409-oxjd263z 207 24 infectious infectious JJ cord-348409-oxjd263z 207 25 diseases disease NNS cord-348409-oxjd263z 207 26 to to TO cord-348409-oxjd263z 207 27 limit limit VB cord-348409-oxjd263z 207 28 the the DT cord-348409-oxjd263z 207 29 harm harm NN cord-348409-oxjd263z 207 30 that that IN cord-348409-oxjd263z 207 31 they -PRON- PRP cord-348409-oxjd263z 207 32 do do VBP cord-348409-oxjd263z 207 33 ( ( -LRB- cord-348409-oxjd263z 207 34 or or CC cord-348409-oxjd263z 207 35 eliminate eliminate VB cord-348409-oxjd263z 207 36 them -PRON- PRP cord-348409-oxjd263z 207 37 ) ) -RRB- cord-348409-oxjd263z 207 38 . . . cord-348409-oxjd263z 208 1 The the DT cord-348409-oxjd263z 208 2 underlying underlying JJ cord-348409-oxjd263z 208 3 principle principle NN cord-348409-oxjd263z 208 4 of of IN cord-348409-oxjd263z 208 5 future future JJ cord-348409-oxjd263z 208 6 IAV iav NN cord-348409-oxjd263z 208 7 - - HYPH cord-348409-oxjd263z 208 8 based base VBN cord-348409-oxjd263z 208 9 vaccine vaccine NN cord-348409-oxjd263z 208 10 development development NN cord-348409-oxjd263z 208 11 could could MD cord-348409-oxjd263z 208 12 be be VB cord-348409-oxjd263z 208 13 based base VBN cord-348409-oxjd263z 208 14 on on IN cord-348409-oxjd263z 208 15 the the DT cord-348409-oxjd263z 208 16 unique unique JJ cord-348409-oxjd263z 208 17 natural natural JJ cord-348409-oxjd263z 208 18 symbiosis symbiosis NN cord-348409-oxjd263z 208 19 , , , cord-348409-oxjd263z 208 20 which which WDT cord-348409-oxjd263z 208 21 is be VBZ cord-348409-oxjd263z 208 22 known know VBN cord-348409-oxjd263z 208 23 to to TO cord-348409-oxjd263z 208 24 exist exist VB cord-348409-oxjd263z 208 25 between between IN cord-348409-oxjd263z 208 26 humans human NNS cord-348409-oxjd263z 208 27 , , , cord-348409-oxjd263z 208 28 non non JJ cord-348409-oxjd263z 208 29 - - JJ cord-348409-oxjd263z 208 30 pathogenic pathogenic JJ cord-348409-oxjd263z 208 31 bacteria bacteria NNS cord-348409-oxjd263z 208 32 such such JJ cord-348409-oxjd263z 208 33 as as IN cord-348409-oxjd263z 208 34 E. E. NNP cord-348409-oxjd263z 208 35 coli coli NNS cord-348409-oxjd263z 208 36 , , , cord-348409-oxjd263z 208 37 and and CC cord-348409-oxjd263z 208 38 inoviruses inoviruse NNS cord-348409-oxjd263z 208 39 . . . cord-348409-oxjd263z 209 1 It -PRON- PRP cord-348409-oxjd263z 209 2 is be VBZ cord-348409-oxjd263z 209 3 well well RB cord-348409-oxjd263z 209 4 established establish VBN cord-348409-oxjd263z 209 5 that that IN cord-348409-oxjd263z 209 6 humans human NNS cord-348409-oxjd263z 209 7 or or CC cord-348409-oxjd263z 209 8 other other JJ cord-348409-oxjd263z 209 9 warm warm JJ cord-348409-oxjd263z 209 10 - - HYPH cord-348409-oxjd263z 209 11 blooded blooded JJ cord-348409-oxjd263z 209 12 animals animal NNS cord-348409-oxjd263z 209 13 acquire acquire VBP cord-348409-oxjd263z 209 14 E.coli E.coli NNS cord-348409-oxjd263z 209 15 , , , cord-348409-oxjd263z 209 16 including include VBG cord-348409-oxjd263z 209 17 F+ F+ NNP cord-348409-oxjd263z 209 18 strains strain NNS cord-348409-oxjd263z 209 19 , , , cord-348409-oxjd263z 209 20 during during IN cord-348409-oxjd263z 209 21 their -PRON- PRP$ cord-348409-oxjd263z 209 22 first first JJ cord-348409-oxjd263z 209 23 few few JJ cord-348409-oxjd263z 209 24 days day NNS cord-348409-oxjd263z 209 25 in in IN cord-348409-oxjd263z 209 26 life life NN cord-348409-oxjd263z 209 27 or or CC cord-348409-oxjd263z 209 28 even even RB cord-348409-oxjd263z 209 29 before before IN cord-348409-oxjd263z 209 30 birth birth NN cord-348409-oxjd263z 209 31 and and CC cord-348409-oxjd263z 209 32 that that IN cord-348409-oxjd263z 209 33 they -PRON- PRP cord-348409-oxjd263z 209 34 are be VBP cord-348409-oxjd263z 209 35 never never RB cord-348409-oxjd263z 209 36 thereafter thereafter RB cord-348409-oxjd263z 209 37 without without IN cord-348409-oxjd263z 209 38 it -PRON- PRP cord-348409-oxjd263z 209 39 . . . cord-348409-oxjd263z 210 1 Fspecific Fspecific NNP cord-348409-oxjd263z 210 2 inoviruses inoviruse NNS cord-348409-oxjd263z 210 3 ( ( -LRB- cord-348409-oxjd263z 210 4 Ff Ff NNP cord-348409-oxjd263z 210 5 inoviruses inoviruses NNP cord-348409-oxjd263z 210 6 ) ) -RRB- cord-348409-oxjd263z 210 7 can can MD cord-348409-oxjd263z 210 8 not not RB cord-348409-oxjd263z 210 9 infect infect VB cord-348409-oxjd263z 210 10 humans human NNS cord-348409-oxjd263z 210 11 , , , cord-348409-oxjd263z 210 12 but but CC cord-348409-oxjd263z 210 13 they -PRON- PRP cord-348409-oxjd263z 210 14 propagate propagate VBP cord-348409-oxjd263z 210 15 at at IN cord-348409-oxjd263z 210 16 high high JJ cord-348409-oxjd263z 210 17 viral viral JJ cord-348409-oxjd263z 210 18 loads load NNS cord-348409-oxjd263z 210 19 in in IN cord-348409-oxjd263z 210 20 specific specific JJ cord-348409-oxjd263z 210 21 strains strain NNS cord-348409-oxjd263z 210 22 of of IN cord-348409-oxjd263z 210 23 E. E. NNP cord-348409-oxjd263z 210 24 coli coli NNS cord-348409-oxjd263z 210 25 including include VBG cord-348409-oxjd263z 210 26 non non JJ cord-348409-oxjd263z 210 27 - - JJ cord-348409-oxjd263z 210 28 pathogenic pathogenic JJ cord-348409-oxjd263z 210 29 strains strain NNS cord-348409-oxjd263z 210 30 which which WDT cord-348409-oxjd263z 210 31 are be VBP cord-348409-oxjd263z 210 32 symbiotic symbiotic JJ cord-348409-oxjd263z 210 33 to to IN cord-348409-oxjd263z 210 34 humans human NNS cord-348409-oxjd263z 210 35 . . . cord-348409-oxjd263z 211 1 Future future JJ cord-348409-oxjd263z 211 2 IAV iav NN cord-348409-oxjd263z 211 3 - - HYPH cord-348409-oxjd263z 211 4 based base VBN cord-348409-oxjd263z 211 5 vaccines vaccine NNS cord-348409-oxjd263z 211 6 within within IN cord-348409-oxjd263z 211 7 the the DT cord-348409-oxjd263z 211 8 next next JJ cord-348409-oxjd263z 211 9 five five CD cord-348409-oxjd263z 211 10 to to TO cord-348409-oxjd263z 211 11 ten ten CD cord-348409-oxjd263z 211 12 years year NNS cord-348409-oxjd263z 211 13 could could MD cord-348409-oxjd263z 211 14 take take VB cord-348409-oxjd263z 211 15 advantage advantage NN cord-348409-oxjd263z 211 16 of of IN cord-348409-oxjd263z 211 17 the the DT cord-348409-oxjd263z 211 18 triple triple JJ cord-348409-oxjd263z 211 19 symbiotic symbiotic JJ cord-348409-oxjd263z 211 20 nature nature NN cord-348409-oxjd263z 211 21 between between IN cord-348409-oxjd263z 211 22 humans human NNS cord-348409-oxjd263z 211 23 , , , cord-348409-oxjd263z 211 24 enteric enteric JJ cord-348409-oxjd263z 211 25 F F NNP cord-348409-oxjd263z 211 26 + + CC cord-348409-oxjd263z 211 27 E. E. NNP cord-348409-oxjd263z 211 28 coli coli VBZ cord-348409-oxjd263z 211 29 strains strain NNS cord-348409-oxjd263z 211 30 and and CC cord-348409-oxjd263z 211 31 F+-specific f+-specific JJ cord-348409-oxjd263z 211 32 inoviruses inoviruse NNS cord-348409-oxjd263z 211 33 to to TO cord-348409-oxjd263z 211 34 target target VB cord-348409-oxjd263z 211 35 the the DT cord-348409-oxjd263z 211 36 induction induction NN cord-348409-oxjd263z 211 37 of of IN cord-348409-oxjd263z 211 38 mucosal mucosal JJ cord-348409-oxjd263z 211 39 immunity immunity NN cord-348409-oxjd263z 211 40 . . . cord-348409-oxjd263z 212 1 This this DT cord-348409-oxjd263z 212 2 approach approach NN cord-348409-oxjd263z 212 3 will will MD cord-348409-oxjd263z 212 4 be be VB cord-348409-oxjd263z 212 5 particularly particularly RB cord-348409-oxjd263z 212 6 effective effective JJ cord-348409-oxjd263z 212 7 against against IN cord-348409-oxjd263z 212 8 sexually sexually RB cord-348409-oxjd263z 212 9 transmitted transmit VBN cord-348409-oxjd263z 212 10 pathogens pathogen NNS cord-348409-oxjd263z 212 11 such such JJ cord-348409-oxjd263z 212 12 as as IN cord-348409-oxjd263z 212 13 HIV-1 HIV-1 NNP cord-348409-oxjd263z 212 14 . . . cord-348409-oxjd263z 213 1 Much much JJ cord-348409-oxjd263z 213 2 future future JJ cord-348409-oxjd263z 213 3 study study NN cord-348409-oxjd263z 213 4 lies lie VBZ cord-348409-oxjd263z 213 5 the the DT cord-348409-oxjd263z 213 6 further further JJ cord-348409-oxjd263z 213 7 development development NN cord-348409-oxjd263z 213 8 of of IN cord-348409-oxjd263z 213 9 IAVs iav NNS cord-348409-oxjd263z 213 10 and and CC cord-348409-oxjd263z 213 11 how how WRB cord-348409-oxjd263z 213 12 they -PRON- PRP cord-348409-oxjd263z 213 13 can can MD cord-348409-oxjd263z 213 14 induce induce VB cord-348409-oxjd263z 213 15 immune immune JJ cord-348409-oxjd263z 213 16 responses response NNS cord-348409-oxjd263z 213 17 on on IN cord-348409-oxjd263z 213 18 a a DT cord-348409-oxjd263z 213 19 broad broad JJ cord-348409-oxjd263z 213 20 scale scale NN cord-348409-oxjd263z 213 21 . . . cord-348409-oxjd263z 214 1 Research research NN cord-348409-oxjd263z 214 2 regarding regard VBG cord-348409-oxjd263z 214 3 the the DT cord-348409-oxjd263z 214 4 development development NN cord-348409-oxjd263z 214 5 and and CC cord-348409-oxjd263z 214 6 advantages advantage NNS cord-348409-oxjd263z 214 7 of of IN cord-348409-oxjd263z 214 8 phage phage NN cord-348409-oxjd263z 214 9 display display NN cord-348409-oxjd263z 214 10 technology technology NN cord-348409-oxjd263z 214 11 was be VBD cord-348409-oxjd263z 214 12 recently recently RB cord-348409-oxjd263z 214 13 recognized recognize VBN cord-348409-oxjd263z 214 14 by by IN cord-348409-oxjd263z 214 15 the the DT cord-348409-oxjd263z 214 16 Nobel Nobel NNP cord-348409-oxjd263z 214 17 Committee Committee NNP cord-348409-oxjd263z 214 18 . . . cord-348409-oxjd263z 215 1 George George NNP cord-348409-oxjd263z 215 2 P. P. NNP cord-348409-oxjd263z 215 3 Smith Smith NNP cord-348409-oxjd263z 215 4 and and CC cord-348409-oxjd263z 215 5 Gregory Gregory NNP cord-348409-oxjd263z 215 6 P. P. NNP cord-348409-oxjd263z 215 7 Winter Winter NNP cord-348409-oxjd263z 215 8 were be VBD cord-348409-oxjd263z 215 9 awarded award VBN cord-348409-oxjd263z 215 10 the the DT cord-348409-oxjd263z 215 11 Nobel Nobel NNP cord-348409-oxjd263z 215 12 Prize Prize NNP cord-348409-oxjd263z 215 13 in in IN cord-348409-oxjd263z 215 14 Chemistry Chemistry NNP cord-348409-oxjd263z 215 15 2018 2018 CD cord-348409-oxjd263z 215 16 for for IN cord-348409-oxjd263z 215 17 the the DT cord-348409-oxjd263z 215 18 ' ' `` cord-348409-oxjd263z 215 19 elegant elegant JJ cord-348409-oxjd263z 215 20 method method NN cord-348409-oxjd263z 215 21 known know VBN cord-348409-oxjd263z 215 22 as as IN cord-348409-oxjd263z 215 23 phage phage NN cord-348409-oxjd263z 215 24 display display NN cord-348409-oxjd263z 215 25 , , , cord-348409-oxjd263z 215 26 where where WRB cord-348409-oxjd263z 215 27 a a DT cord-348409-oxjd263z 215 28 bacteriophagea bacteriophagea JJ cord-348409-oxjd263z 215 29 virus virus NN cord-348409-oxjd263z 215 30 that that WDT cord-348409-oxjd263z 215 31 infects infect VBZ cord-348409-oxjd263z 215 32 bacteriacan bacteriacan NNP cord-348409-oxjd263z 215 33 be be VB cord-348409-oxjd263z 215 34 used use VBN cord-348409-oxjd263z 215 35 to to TO cord-348409-oxjd263z 215 36 evolve evolve VB cord-348409-oxjd263z 215 37 new new JJ cord-348409-oxjd263z 215 38 proteins protein NNS cord-348409-oxjd263z 215 39 … … NFP cord-348409-oxjd263z 216 1 [ [ -LRB- cord-348409-oxjd263z 216 2 This this DT cord-348409-oxjd263z 216 3 ] ] -RRB- cord-348409-oxjd263z 216 4 revolution revolution NN cord-348409-oxjd263z 216 5 … … NFP cord-348409-oxjd263z 216 6 is be VBZ cord-348409-oxjd263z 216 7 bringing bring VBG cord-348409-oxjd263z 216 8 and and CC cord-348409-oxjd263z 216 9 will will MD cord-348409-oxjd263z 216 10 bring bring VB cord-348409-oxjd263z 216 11 the the DT cord-348409-oxjd263z 216 12 greatest great JJS cord-348409-oxjd263z 216 13 benefit benefit NN cord-348409-oxjd263z 216 14 to to IN cord-348409-oxjd263z 216 15 humankind humankind NN cord-348409-oxjd263z 216 16 ' ' '' cord-348409-oxjd263z 216 17 [ [ -LRB- cord-348409-oxjd263z 216 18 108 108 CD cord-348409-oxjd263z 216 19 ] ] -RRB- cord-348409-oxjd263z 216 20 . . . cord-348409-oxjd263z 217 1 The the DT cord-348409-oxjd263z 217 2 development development NN cord-348409-oxjd263z 217 3 of of IN cord-348409-oxjd263z 217 4 more more JJR cord-348409-oxjd263z 217 5 and and CC cord-348409-oxjd263z 217 6 better well RBR cord-348409-oxjd263z 217 7 inovirus inovirus NNP cord-348409-oxjd263z 217 8 - - HYPH cord-348409-oxjd263z 217 9 based base VBN cord-348409-oxjd263z 217 10 vaccines vaccine NNS cord-348409-oxjd263z 217 11 will will MD cord-348409-oxjd263z 217 12 continue continue VB cord-348409-oxjd263z 217 13 to to TO cord-348409-oxjd263z 217 14 advance advance VB cord-348409-oxjd263z 217 15 preventative preventative JJ cord-348409-oxjd263z 217 16 treatment treatment NN cord-348409-oxjd263z 217 17 against against IN cord-348409-oxjd263z 217 18 diseases disease NNS cord-348409-oxjd263z 217 19 which which WDT cord-348409-oxjd263z 217 20 have have VBP cord-348409-oxjd263z 217 21 not not RB cord-348409-oxjd263z 217 22 been be VBN cord-348409-oxjd263z 217 23 able able JJ cord-348409-oxjd263z 217 24 to to TO cord-348409-oxjd263z 217 25 be be VB cord-348409-oxjd263z 217 26 combatted combat VBN cord-348409-oxjd263z 217 27 . . . cord-348409-oxjd263z 218 1 Papers paper NNS cord-348409-oxjd263z 218 2 of of IN cord-348409-oxjd263z 218 3 special special JJ cord-348409-oxjd263z 218 4 note note NN cord-348409-oxjd263z 218 5 have have VBP cord-348409-oxjd263z 218 6 been be VBN cord-348409-oxjd263z 218 7 highlighted highlight VBN cord-348409-oxjd263z 218 8 as as IN cord-348409-oxjd263z 218 9 either either DT cord-348409-oxjd263z 218 10 of of IN cord-348409-oxjd263z 218 11 interest interest NN cord-348409-oxjd263z 218 12 ( ( -LRB- cord-348409-oxjd263z 218 13 • • NNP cord-348409-oxjd263z 218 14 ) ) -RRB- cord-348409-oxjd263z 218 15 or or CC cord-348409-oxjd263z 218 16 of of IN cord-348409-oxjd263z 218 17 considerable considerable JJ cord-348409-oxjd263z 218 18 interest interest NN cord-348409-oxjd263z 218 19 ( ( -LRB- cord-348409-oxjd263z 218 20 •• •• CD cord-348409-oxjd263z 218 21 ) ) -RRB- cord-348409-oxjd263z 218 22 to to IN cord-348409-oxjd263z 218 23 readers reader NNS cord-348409-oxjd263z 218 24 An an DT cord-348409-oxjd263z 218 25 investigation investigation NN cord-348409-oxjd263z 218 26 on on IN cord-348409-oxjd263z 218 27 the the DT cord-348409-oxjd263z 218 28 nature nature NN cord-348409-oxjd263z 218 29 of of IN cord-348409-oxjd263z 218 30 ultra ultra JJ cord-348409-oxjd263z 218 31 - - JJ cord-348409-oxjd263z 218 32 microscopic microscopic JJ cord-348409-oxjd263z 218 33 viruses virus NNS cord-348409-oxjd263z 219 1 Sur Sur NNP cord-348409-oxjd263z 219 2 un un NNP cord-348409-oxjd263z 219 3 microbe microbe NN cord-348409-oxjd263z 219 4 invisible invisible JJ cord-348409-oxjd263z 219 5 antagoniste antagoniste FW cord-348409-oxjd263z 219 6 des des FW cord-348409-oxjd263z 219 7 bacilles bacilles FW cord-348409-oxjd263z 219 8 dysentériques dysentériques NNP cord-348409-oxjd263z 219 9 Phage Phage NNP cord-348409-oxjd263z 219 10 display display NN cord-348409-oxjd263z 219 11 as as IN cord-348409-oxjd263z 219 12 a a DT cord-348409-oxjd263z 219 13 promising promising JJ cord-348409-oxjd263z 219 14 approach approach NN cord-348409-oxjd263z 219 15 for for IN cord-348409-oxjd263z 219 16 vaccine vaccine NN cord-348409-oxjd263z 219 17 development development NN cord-348409-oxjd263z 220 1 Beyond beyond IN cord-348409-oxjd263z 220 2 phage phage NN cord-348409-oxjd263z 220 3 display display NN cord-348409-oxjd263z 220 4 : : : cord-348409-oxjd263z 220 5 non non JJ cord-348409-oxjd263z 220 6 - - JJ cord-348409-oxjd263z 220 7 traditional traditional JJ cord-348409-oxjd263z 220 8 applications application NNS cord-348409-oxjd263z 220 9 of of IN cord-348409-oxjd263z 220 10 the the DT cord-348409-oxjd263z 220 11 filamentous filamentous JJ cord-348409-oxjd263z 220 12 bacteriophage bacteriophage NN cord-348409-oxjd263z 220 13 as as IN cord-348409-oxjd263z 220 14 a a DT cord-348409-oxjd263z 220 15 vaccine vaccine NN cord-348409-oxjd263z 220 16 carrier carrier NN cord-348409-oxjd263z 220 17 , , , cord-348409-oxjd263z 220 18 therapeutic therapeutic JJ cord-348409-oxjd263z 220 19 biologic biologic NN cord-348409-oxjd263z 220 20 , , , cord-348409-oxjd263z 220 21 and and CC cord-348409-oxjd263z 220 22 bioconjugation bioconjugation NN cord-348409-oxjd263z 220 23 scaffold scaffold NN cord-348409-oxjd263z 221 1 • • NNP cord-348409-oxjd263z 222 1 A a DT cord-348409-oxjd263z 222 2 review review NN cord-348409-oxjd263z 222 3 of of IN cord-348409-oxjd263z 222 4 novel novel JJ cord-348409-oxjd263z 222 5 future future JJ cord-348409-oxjd263z 222 6 applications application NNS cord-348409-oxjd263z 222 7 of of IN cord-348409-oxjd263z 222 8 phage phage NN cord-348409-oxjd263z 222 9 - - HYPH cord-348409-oxjd263z 222 10 display display NN cord-348409-oxjd263z 222 11 technology technology NN cord-348409-oxjd263z 222 12 Mahy Mahy NNP cord-348409-oxjd263z 222 13 BWJ BWJ NNP cord-348409-oxjd263z 222 14 , , , cord-348409-oxjd263z 222 15 Regenmortel Regenmortel NNP cord-348409-oxjd263z 222 16 MHVV MHVV NNP cord-348409-oxjd263z 222 17 Structure Structure NNP cord-348409-oxjd263z 222 18 and and CC cord-348409-oxjd263z 222 19 assembly assembly NN cord-348409-oxjd263z 222 20 of of IN cord-348409-oxjd263z 222 21 filamentous filamentous JJ cord-348409-oxjd263z 222 22 bacteriophages bacteriophage NNS cord-348409-oxjd263z 222 23 DNA dna NN cord-348409-oxjd263z 222 24 packing packing NN cord-348409-oxjd263z 222 25 in in IN cord-348409-oxjd263z 222 26 filamentous filamentous JJ cord-348409-oxjd263z 222 27 bacteriophages bacteriophage NNS cord-348409-oxjd263z 222 28 Replication Replication NNP cord-348409-oxjd263z 222 29 of of IN cord-348409-oxjd263z 222 30 coliphage coliphage NN cord-348409-oxjd263z 222 31 M-13 M-13 NNP cord-348409-oxjd263z 222 32 . . . cord-348409-oxjd263z 223 1 I. I. NNP cord-348409-oxjd263z 223 2 Effects effect NNS cord-348409-oxjd263z 223 3 on on IN cord-348409-oxjd263z 223 4 host host NN cord-348409-oxjd263z 223 5 cells cell NNS cord-348409-oxjd263z 223 6 after after IN cord-348409-oxjd263z 223 7 synchronized synchronize VBN cord-348409-oxjd263z 223 8 infection infection NN cord-348409-oxjd263z 223 9 Filamentous Filamentous NNP cord-348409-oxjd263z 223 10 bacterial bacterial JJ cord-348409-oxjd263z 223 11 viruses virus NNS cord-348409-oxjd263z 224 1 Filamentous Filamentous NNP cord-348409-oxjd263z 224 2 bacteriophage bacteriophage NN cord-348409-oxjd263z 224 3 : : : cord-348409-oxjd263z 224 4 biology biology NN cord-348409-oxjd263z 224 5 , , , cord-348409-oxjd263z 224 6 phage phage NN cord-348409-oxjd263z 224 7 display display NN cord-348409-oxjd263z 224 8 and and CC cord-348409-oxjd263z 224 9 nanotechnology nanotechnology NN cord-348409-oxjd263z 224 10 applications application NNS cord-348409-oxjd263z 225 1 A a DT cord-348409-oxjd263z 225 2 recent recent JJ cord-348409-oxjd263z 225 3 comprehensive comprehensive JJ cord-348409-oxjd263z 225 4 review review NN cord-348409-oxjd263z 225 5 about about IN cord-348409-oxjd263z 225 6 the the DT cord-348409-oxjd263z 225 7 molecular molecular JJ cord-348409-oxjd263z 225 8 biology biology NN cord-348409-oxjd263z 225 9 and and CC cord-348409-oxjd263z 225 10 life life NN cord-348409-oxjd263z 225 11 cycle cycle NN cord-348409-oxjd263z 225 12 of of IN cord-348409-oxjd263z 225 13 Ff Ff NNP cord-348409-oxjd263z 225 14 viruses virus NNS cord-348409-oxjd263z 225 15 ( ( -LRB- cord-348409-oxjd263z 225 16 F f NN cord-348409-oxjd263z 225 17 + + CC cord-348409-oxjd263z 225 18 -specific -specific JJ cord-348409-oxjd263z 225 19 filamentous filamentous JJ cord-348409-oxjd263z 225 20 viruses virus NNS cord-348409-oxjd263z 225 21 ) ) -RRB- cord-348409-oxjd263z 226 1 Filamentous Filamentous NNP cord-348409-oxjd263z 226 2 Phage Phage NNP cord-348409-oxjd263z 226 3 : : : cord-348409-oxjd263z 226 4 structure structure NN cord-348409-oxjd263z 226 5 and and CC cord-348409-oxjd263z 226 6 Biology biology NN cord-348409-oxjd263z 226 7 Nucleotide Nucleotide NNP cord-348409-oxjd263z 226 8 sequence sequence NN cord-348409-oxjd263z 226 9 of of IN cord-348409-oxjd263z 226 10 bacteriophage bacteriophage NN cord-348409-oxjd263z 226 11 fd fd NNP cord-348409-oxjd263z 226 12 DNA DNA NNP cord-348409-oxjd263z 226 13 Nucleotide Nucleotide NNP cord-348409-oxjd263z 226 14 sequence sequence NN cord-348409-oxjd263z 226 15 of of IN cord-348409-oxjd263z 226 16 bacteriophage bacteriophage NN cord-348409-oxjd263z 226 17 f1 f1 NNP cord-348409-oxjd263z 226 18 DNA DNA NNP cord-348409-oxjd263z 226 19 Nucleotide Nucleotide NNP cord-348409-oxjd263z 226 20 sequence sequence NN cord-348409-oxjd263z 226 21 of of IN cord-348409-oxjd263z 226 22 the the DT cord-348409-oxjd263z 226 23 filamentous filamentous JJ cord-348409-oxjd263z 226 24 bacteriophage bacteriophage NN cord-348409-oxjd263z 226 25 M13 M13 NNP cord-348409-oxjd263z 226 26 DNA dna NN cord-348409-oxjd263z 226 27 genome genome NN cord-348409-oxjd263z 226 28 : : : cord-348409-oxjd263z 226 29 comparison comparison NN cord-348409-oxjd263z 226 30 with with IN cord-348409-oxjd263z 226 31 phage phage NN cord-348409-oxjd263z 226 32 fd fd NNP cord-348409-oxjd263z 226 33 Genetic genetic JJ cord-348409-oxjd263z 226 34 analysis analysis NN cord-348409-oxjd263z 226 35 of of IN cord-348409-oxjd263z 226 36 the the DT cord-348409-oxjd263z 226 37 filamentous filamentous JJ cord-348409-oxjd263z 226 38 bacteriophage bacteriophage NN cord-348409-oxjd263z 226 39 packaging packaging NN cord-348409-oxjd263z 226 40 signal signal NN cord-348409-oxjd263z 226 41 and and CC cord-348409-oxjd263z 226 42 of of IN cord-348409-oxjd263z 226 43 the the DT cord-348409-oxjd263z 226 44 proteins protein NNS cord-348409-oxjd263z 226 45 that that WDT cord-348409-oxjd263z 226 46 interact interact VBP cord-348409-oxjd263z 226 47 with with IN cord-348409-oxjd263z 226 48 it -PRON- PRP cord-348409-oxjd263z 226 49 Functional functional JJ cord-348409-oxjd263z 226 50 analysis analysis NN cord-348409-oxjd263z 226 51 of of IN cord-348409-oxjd263z 226 52 bacteriophage bacteriophage NN cord-348409-oxjd263z 226 53 f1 f1 NNP cord-348409-oxjd263z 226 54 intergenic intergenic JJ cord-348409-oxjd263z 226 55 region region NN cord-348409-oxjd263z 226 56 Filamentous Filamentous NNP cord-348409-oxjd263z 226 57 phage phage NN cord-348409-oxjd263z 226 58 morphogenetic morphogenetic JJ cord-348409-oxjd263z 226 59 signal signal NN cord-348409-oxjd263z 226 60 sequence sequence NN cord-348409-oxjd263z 226 61 and and CC cord-348409-oxjd263z 226 62 orientation orientation NN cord-348409-oxjd263z 226 63 of of IN cord-348409-oxjd263z 226 64 DNA dna NN cord-348409-oxjd263z 226 65 in in IN cord-348409-oxjd263z 226 66 the the DT cord-348409-oxjd263z 226 67 virion virion NN cord-348409-oxjd263z 226 68 and and CC cord-348409-oxjd263z 226 69 gene gene NN cord-348409-oxjd263z 226 70 - - HYPH cord-348409-oxjd263z 226 71 V v NN cord-348409-oxjd263z 226 72 protein protein NN cord-348409-oxjd263z 227 1 complex complex JJ cord-348409-oxjd263z 227 2 A a DT cord-348409-oxjd263z 227 3 specific specific JJ cord-348409-oxjd263z 227 4 DNA dna NN cord-348409-oxjd263z 227 5 orientation orientation NN cord-348409-oxjd263z 227 6 in in IN cord-348409-oxjd263z 227 7 the the DT cord-348409-oxjd263z 227 8 filamentous filamentous JJ cord-348409-oxjd263z 227 9 bacteriophage bacteriophage NN cord-348409-oxjd263z 227 10 fd fd NNP cord-348409-oxjd263z 227 11 as as IN cord-348409-oxjd263z 227 12 probed probe VBN cord-348409-oxjd263z 227 13 by by IN cord-348409-oxjd263z 227 14 psoralen psoralen NN cord-348409-oxjd263z 227 15 crosslinking crosslinking NN cord-348409-oxjd263z 227 16 and and CC cord-348409-oxjd263z 227 17 electron electron NN cord-348409-oxjd263z 227 18 microscopy microscopy NN cord-348409-oxjd263z 227 19 Morphogenesis morphogenesis NN cord-348409-oxjd263z 227 20 of of IN cord-348409-oxjd263z 227 21 filamentous filamentous JJ cord-348409-oxjd263z 227 22 bacteriophage bacteriophage NN cord-348409-oxjd263z 227 23 f1 f1 NNP cord-348409-oxjd263z 227 24 : : : cord-348409-oxjd263z 227 25 orientation orientation NN cord-348409-oxjd263z 227 26 of of IN cord-348409-oxjd263z 227 27 extrusion extrusion NN cord-348409-oxjd263z 227 28 and and CC cord-348409-oxjd263z 227 29 production production NN cord-348409-oxjd263z 227 30 of of IN cord-348409-oxjd263z 227 31 polyphage polyphage NN cord-348409-oxjd263z 227 32 Orientation Orientation NNP cord-348409-oxjd263z 227 33 of of IN cord-348409-oxjd263z 227 34 the the DT cord-348409-oxjd263z 227 35 DNA dna NN cord-348409-oxjd263z 227 36 in in IN cord-348409-oxjd263z 227 37 the the DT cord-348409-oxjd263z 227 38 filamentous filamentous JJ cord-348409-oxjd263z 227 39 bacteriophage bacteriophage NN cord-348409-oxjd263z 228 1 f1 f1 NNP cord-348409-oxjd263z 229 1 The the DT cord-348409-oxjd263z 229 2 symmetries symmetry NNS cord-348409-oxjd263z 229 3 of of IN cord-348409-oxjd263z 229 4 filamentous filamentous JJ cord-348409-oxjd263z 229 5 phage phage NN cord-348409-oxjd263z 229 6 particles particle NNS cord-348409-oxjd263z 229 7 Helical helical JJ cord-348409-oxjd263z 229 8 viruses virus NNS cord-348409-oxjd263z 229 9 Three three CD cord-348409-oxjd263z 229 10 - - HYPH cord-348409-oxjd263z 229 11 dimensional dimensional JJ cord-348409-oxjd263z 229 12 structure structure NN cord-348409-oxjd263z 229 13 of of IN cord-348409-oxjd263z 229 14 a a DT cord-348409-oxjd263z 229 15 cloning cloning NN cord-348409-oxjd263z 229 16 vector vector NN cord-348409-oxjd263z 229 17 . . . cord-348409-oxjd263z 230 1 X x NN cord-348409-oxjd263z 230 2 - - NN cord-348409-oxjd263z 230 3 ray ray NN cord-348409-oxjd263z 230 4 diffraction diffraction NN cord-348409-oxjd263z 230 5 studies study NNS cord-348409-oxjd263z 230 6 of of IN cord-348409-oxjd263z 230 7 filamentous filamentous JJ cord-348409-oxjd263z 230 8 bacteriophage bacteriophage NN cord-348409-oxjd263z 230 9 M13 M13 NNP cord-348409-oxjd263z 230 10 at at IN cord-348409-oxjd263z 230 11 7 7 CD cord-348409-oxjd263z 230 12 A a DT cord-348409-oxjd263z 230 13 resolution resolution NN cord-348409-oxjd263z 230 14 Chemical chemical JJ cord-348409-oxjd263z 230 15 modification modification NN cord-348409-oxjd263z 230 16 of of IN cord-348409-oxjd263z 230 17 the the DT cord-348409-oxjd263z 230 18 coat coat NN cord-348409-oxjd263z 230 19 protein protein NN cord-348409-oxjd263z 230 20 in in IN cord-348409-oxjd263z 230 21 bacteriophage bacteriophage NN cord-348409-oxjd263z 230 22 fd fd NN cord-348409-oxjd263z 230 23 and and CC cord-348409-oxjd263z 230 24 orientation orientation NN cord-348409-oxjd263z 230 25 of of IN cord-348409-oxjd263z 230 26 the the DT cord-348409-oxjd263z 230 27 virion virion NN cord-348409-oxjd263z 230 28 during during IN cord-348409-oxjd263z 230 29 assembly assembly NN cord-348409-oxjd263z 230 30 and and CC cord-348409-oxjd263z 230 31 disassembly disassembly NN cord-348409-oxjd263z 230 32 Bacteriophage Bacteriophage NNP cord-348409-oxjd263z 230 33 f1 f1 NNP cord-348409-oxjd263z 230 34 infection infection NN cord-348409-oxjd263z 230 35 : : : cord-348409-oxjd263z 230 36 fate fate NN cord-348409-oxjd263z 230 37 of of IN cord-348409-oxjd263z 230 38 the the DT cord-348409-oxjd263z 230 39 parental parental JJ cord-348409-oxjd263z 230 40 major major JJ cord-348409-oxjd263z 230 41 coat coat NN cord-348409-oxjd263z 230 42 protein protein NN cord-348409-oxjd263z 231 1 The the DT cord-348409-oxjd263z 231 2 fate fate NN cord-348409-oxjd263z 231 3 of of IN cord-348409-oxjd263z 231 4 the the DT cord-348409-oxjd263z 231 5 protein protein NN cord-348409-oxjd263z 231 6 component component NN cord-348409-oxjd263z 231 7 of of IN cord-348409-oxjd263z 231 8 bacteriophage bacteriophage NN cord-348409-oxjd263z 231 9 fd fd NNP cord-348409-oxjd263z 231 10 during during IN cord-348409-oxjd263z 231 11 infection infection NN cord-348409-oxjd263z 231 12 Detection detection NN cord-348409-oxjd263z 231 13 of of IN cord-348409-oxjd263z 231 14 prokaryotic prokaryotic JJ cord-348409-oxjd263z 231 15 signal signal NN cord-348409-oxjd263z 231 16 peptidase peptidase NN cord-348409-oxjd263z 231 17 in in IN cord-348409-oxjd263z 231 18 an an DT cord-348409-oxjd263z 231 19 Escherichia Escherichia NNP cord-348409-oxjd263z 231 20 coli coli NNS cord-348409-oxjd263z 231 21 membrane membrane NN cord-348409-oxjd263z 231 22 fraction fraction NN cord-348409-oxjd263z 231 23 : : : cord-348409-oxjd263z 231 24 endoproteolytic endoproteolytic JJ cord-348409-oxjd263z 231 25 cleavage cleavage NN cord-348409-oxjd263z 231 26 of of IN cord-348409-oxjd263z 231 27 nascent nascent JJ cord-348409-oxjd263z 231 28 f1 f1 NNP cord-348409-oxjd263z 231 29 pre pre JJ cord-348409-oxjd263z 231 30 - - JJ cord-348409-oxjd263z 231 31 coat coat JJ cord-348409-oxjd263z 231 32 protein protein NN cord-348409-oxjd263z 231 33 Isolation isolation NN cord-348409-oxjd263z 231 34 of of IN cord-348409-oxjd263z 231 35 mutants mutant NNS cord-348409-oxjd263z 231 36 in in IN cord-348409-oxjd263z 231 37 M13 M13 NNP cord-348409-oxjd263z 231 38 coat coat NN cord-348409-oxjd263z 231 39 protein protein NN cord-348409-oxjd263z 231 40 that that WDT cord-348409-oxjd263z 231 41 affect affect VBP cord-348409-oxjd263z 231 42 its -PRON- PRP$ cord-348409-oxjd263z 231 43 synthesis synthesis NN cord-348409-oxjd263z 231 44 , , , cord-348409-oxjd263z 231 45 processing processing NN cord-348409-oxjd263z 231 46 , , , cord-348409-oxjd263z 231 47 and and CC cord-348409-oxjd263z 231 48 assembly assembly NN cord-348409-oxjd263z 231 49 into into IN cord-348409-oxjd263z 231 50 phage phage NN cord-348409-oxjd263z 231 51 Conserved conserve VBN cord-348409-oxjd263z 231 52 residues residue NNS cord-348409-oxjd263z 231 53 of of IN cord-348409-oxjd263z 231 54 the the DT cord-348409-oxjd263z 231 55 leader leader NN cord-348409-oxjd263z 231 56 peptide peptide NN cord-348409-oxjd263z 231 57 are be VBP cord-348409-oxjd263z 231 58 essential essential JJ cord-348409-oxjd263z 231 59 for for IN cord-348409-oxjd263z 231 60 cleavage cleavage NN cord-348409-oxjd263z 231 61 by by IN cord-348409-oxjd263z 231 62 leader leader NN cord-348409-oxjd263z 231 63 peptidase peptidase NN cord-348409-oxjd263z 231 64 Filamentous Filamentous NNP cord-348409-oxjd263z 231 65 phage phage NN cord-348409-oxjd263z 231 66 are be VBP cord-348409-oxjd263z 231 67 released release VBN cord-348409-oxjd263z 231 68 from from IN cord-348409-oxjd263z 231 69 the the DT cord-348409-oxjd263z 231 70 bacterial bacterial JJ cord-348409-oxjd263z 231 71 membrane membrane NN cord-348409-oxjd263z 231 72 by by IN cord-348409-oxjd263z 231 73 a a DT cord-348409-oxjd263z 231 74 two two CD cord-348409-oxjd263z 231 75 - - HYPH cord-348409-oxjd263z 231 76 step step NN cord-348409-oxjd263z 231 77 mechanism mechanism NN cord-348409-oxjd263z 231 78 involving involve VBG cord-348409-oxjd263z 231 79 a a DT cord-348409-oxjd263z 231 80 short short JJ cord-348409-oxjd263z 231 81 C c NN cord-348409-oxjd263z 231 82 - - HYPH cord-348409-oxjd263z 231 83 terminal terminal NN cord-348409-oxjd263z 231 84 fragment fragment NN cord-348409-oxjd263z 231 85 of of IN cord-348409-oxjd263z 231 86 pIII pIII NFP cord-348409-oxjd263z 231 87 Architectural architectural JJ cord-348409-oxjd263z 231 88 insight insight NN cord-348409-oxjd263z 231 89 into into IN cord-348409-oxjd263z 231 90 inovirus inovirus NNP cord-348409-oxjd263z 231 91 - - HYPH cord-348409-oxjd263z 231 92 associated associate VBN cord-348409-oxjd263z 231 93 vectors vector NNS cord-348409-oxjd263z 231 94 ( ( -LRB- cord-348409-oxjd263z 231 95 IAVs IAVs NNP cord-348409-oxjd263z 231 96 ) ) -RRB- cord-348409-oxjd263z 231 97 and and CC cord-348409-oxjd263z 231 98 development development NN cord-348409-oxjd263z 231 99 of of IN cord-348409-oxjd263z 231 100 IAV IAV NNP cord-348409-oxjd263z 231 101 - - HYPH cord-348409-oxjd263z 231 102 based base VBN cord-348409-oxjd263z 231 103 vaccines vaccine NNS cord-348409-oxjd263z 231 104 inducing induce VBG cord-348409-oxjd263z 231 105 humoral humoral JJ cord-348409-oxjd263z 231 106 and and CC cord-348409-oxjd263z 231 107 cellular cellular JJ cord-348409-oxjd263z 231 108 responses response NNS cord-348409-oxjd263z 231 109 : : : cord-348409-oxjd263z 231 110 implications implication NNS cord-348409-oxjd263z 231 111 in in IN cord-348409-oxjd263z 231 112 HIV-1 HIV-1 NNP cord-348409-oxjd263z 231 113 vaccines vaccine VBZ cord-348409-oxjd263z 231 114 A a DT cord-348409-oxjd263z 231 115 detailed detailed JJ cord-348409-oxjd263z 231 116 review review NN cord-348409-oxjd263z 231 117 of of IN cord-348409-oxjd263z 231 118 the the DT cord-348409-oxjd263z 231 119 architecture architecture NN cord-348409-oxjd263z 231 120 of of IN cord-348409-oxjd263z 231 121 inoviruses inoviruses NNP cord-348409-oxjd263z 231 122 and and CC cord-348409-oxjd263z 231 123 major major JJ cord-348409-oxjd263z 231 124 inovirus inovirus NNP cord-348409-oxjd263z 231 125 - - HYPH cord-348409-oxjd263z 231 126 associated associate VBN cord-348409-oxjd263z 231 127 vectors vector NNS cord-348409-oxjd263z 231 128 ( ( -LRB- cord-348409-oxjd263z 231 129 IAVs iav NNS cord-348409-oxjd263z 231 130 ) ) -RRB- cord-348409-oxjd263z 231 131 and and CC cord-348409-oxjd263z 231 132 related relate VBN cord-348409-oxjd263z 231 133 vaccines vaccine NNS cord-348409-oxjd263z 231 134 Libraries library NNS cord-348409-oxjd263z 231 135 of of IN cord-348409-oxjd263z 231 136 peptides peptide NNS cord-348409-oxjd263z 231 137 and and CC cord-348409-oxjd263z 231 138 proteins protein NNS cord-348409-oxjd263z 231 139 displayed display VBN cord-348409-oxjd263z 231 140 on on IN cord-348409-oxjd263z 231 141 filamentous filamentous JJ cord-348409-oxjd263z 231 142 phage phage NN cord-348409-oxjd263z 231 143 Phage phage NN cord-348409-oxjd263z 231 144 Display display NN cord-348409-oxjd263z 232 1 • • NNP cord-348409-oxjd263z 233 1 An an DT cord-348409-oxjd263z 233 2 early early JJ cord-348409-oxjd263z 233 3 overview overview NN cord-348409-oxjd263z 233 4 of of IN cord-348409-oxjd263z 233 5 the the DT cord-348409-oxjd263z 233 6 phage phage NN cord-348409-oxjd263z 233 7 - - HYPH cord-348409-oxjd263z 233 8 display display NN cord-348409-oxjd263z 233 9 and and CC cord-348409-oxjd263z 233 10 its -PRON- PRP$ cord-348409-oxjd263z 233 11 applications application NNS cord-348409-oxjd263z 233 12 Eliminating eliminate VBG cord-348409-oxjd263z 233 13 helper helper NN cord-348409-oxjd263z 233 14 phage phage NN cord-348409-oxjd263z 233 15 from from IN cord-348409-oxjd263z 233 16 phage phage NN cord-348409-oxjd263z 233 17 display display NN cord-348409-oxjd263z 233 18 Identification identification NN cord-348409-oxjd263z 233 19 of of IN cord-348409-oxjd263z 233 20 peroxisomal peroxisomal JJ cord-348409-oxjd263z 233 21 proteins protein NNS cord-348409-oxjd263z 233 22 by by IN cord-348409-oxjd263z 233 23 using use VBG cord-348409-oxjd263z 233 24 M13 M13 NNP cord-348409-oxjd263z 233 25 phage phage NN cord-348409-oxjd263z 233 26 protein protein NN cord-348409-oxjd263z 233 27 VI VI NNP cord-348409-oxjd263z 233 28 phage phage NN cord-348409-oxjd263z 233 29 display display NN cord-348409-oxjd263z 233 30 : : : cord-348409-oxjd263z 233 31 molecular molecular JJ cord-348409-oxjd263z 233 32 evidence evidence NN cord-348409-oxjd263z 233 33 that that IN cord-348409-oxjd263z 233 34 mammalian mammalian JJ cord-348409-oxjd263z 233 35 peroxisomes peroxisome NNS cord-348409-oxjd263z 233 36 contain contain VBP cord-348409-oxjd263z 233 37 a a DT cord-348409-oxjd263z 233 38 2,4-dienoyl 2,4-dienoyl CD cord-348409-oxjd263z 233 39 - - HYPH cord-348409-oxjd263z 233 40 CoA coa NN cord-348409-oxjd263z 233 41 reductase reductase NN cord-348409-oxjd263z 233 42 Phage Phage NNP cord-348409-oxjd263z 233 43 display display NN cord-348409-oxjd263z 233 44 of of IN cord-348409-oxjd263z 233 45 cDNA cdna NN cord-348409-oxjd263z 233 46 repertoires repertoire NNS cord-348409-oxjd263z 233 47 : : : cord-348409-oxjd263z 233 48 the the DT cord-348409-oxjd263z 233 49 pVI pVI NNP cord-348409-oxjd263z 233 50 display display NN cord-348409-oxjd263z 233 51 system system NN cord-348409-oxjd263z 233 52 and and CC cord-348409-oxjd263z 233 53 its -PRON- PRP$ cord-348409-oxjd263z 233 54 applications application NNS cord-348409-oxjd263z 233 55 for for IN cord-348409-oxjd263z 233 56 the the DT cord-348409-oxjd263z 233 57 selection selection NN cord-348409-oxjd263z 233 58 of of IN cord-348409-oxjd263z 233 59 immunogenic immunogenic JJ cord-348409-oxjd263z 233 60 ligands ligand NNS cord-348409-oxjd263z 233 61 Surface Surface NNP cord-348409-oxjd263z 233 62 expression expression NN cord-348409-oxjd263z 233 63 and and CC cord-348409-oxjd263z 233 64 ligand ligand NN cord-348409-oxjd263z 233 65 - - HYPH cord-348409-oxjd263z 233 66 based base VBN cord-348409-oxjd263z 233 67 selection selection NN cord-348409-oxjd263z 233 68 of of IN cord-348409-oxjd263z 233 69 cDNAs cdna NNS cord-348409-oxjd263z 233 70 fused fuse VBN cord-348409-oxjd263z 233 71 to to IN cord-348409-oxjd263z 233 72 filamentous filamentous JJ cord-348409-oxjd263z 233 73 phage phage NN cord-348409-oxjd263z 233 74 gene gene NN cord-348409-oxjd263z 233 75 VI VI NNP cord-348409-oxjd263z 233 76 Multivalent Multivalent NNP cord-348409-oxjd263z 233 77 display display NN cord-348409-oxjd263z 233 78 system system NN cord-348409-oxjd263z 233 79 on on IN cord-348409-oxjd263z 233 80 filamentous filamentous JJ cord-348409-oxjd263z 233 81 bacteriophage bacteriophage NN cord-348409-oxjd263z 233 82 pVII pvii NN cord-348409-oxjd263z 233 83 minor minor JJ cord-348409-oxjd263z 233 84 coat coat NN cord-348409-oxjd263z 233 85 protein protein NN cord-348409-oxjd263z 233 86 Membrane Membrane NNP cord-348409-oxjd263z 233 87 insertion insertion NN cord-348409-oxjd263z 233 88 and and CC cord-348409-oxjd263z 233 89 assembly assembly NN cord-348409-oxjd263z 233 90 of of IN cord-348409-oxjd263z 233 91 epitopetagged epitopetagged NNP cord-348409-oxjd263z 233 92 gp9 gp9 CC cord-348409-oxjd263z 233 93 at at IN cord-348409-oxjd263z 233 94 the the DT cord-348409-oxjd263z 233 95 tip tip NN cord-348409-oxjd263z 233 96 of of IN cord-348409-oxjd263z 233 97 the the DT cord-348409-oxjd263z 233 98 M13 M13 NNP cord-348409-oxjd263z 233 99 phage phage NN cord-348409-oxjd263z 233 100 Next next JJ cord-348409-oxjd263z 233 101 generation generation NN cord-348409-oxjd263z 233 102 phage phage NN cord-348409-oxjd263z 233 103 display display NN cord-348409-oxjd263z 233 104 by by IN cord-348409-oxjd263z 233 105 use use NN cord-348409-oxjd263z 233 106 of of IN cord-348409-oxjd263z 233 107 pVII pvii NN cord-348409-oxjd263z 233 108 and and CC cord-348409-oxjd263z 233 109 pIX pix NN cord-348409-oxjd263z 233 110 as as IN cord-348409-oxjd263z 233 111 display display NN cord-348409-oxjd263z 233 112 scaffolds scaffold NNS cord-348409-oxjd263z 233 113 Phage Phage NNP cord-348409-oxjd263z 233 114 display display NN cord-348409-oxjd263z 233 115 : : : cord-348409-oxjd263z 233 116 concept concept NN cord-348409-oxjd263z 233 117 , , , cord-348409-oxjd263z 233 118 innovations innovation NNS cord-348409-oxjd263z 233 119 , , , cord-348409-oxjd263z 233 120 applications application NNS cord-348409-oxjd263z 233 121 and and CC cord-348409-oxjd263z 233 122 future future JJ cord-348409-oxjd263z 233 123 Vaccination vaccination NN cord-348409-oxjd263z 233 124 with with IN cord-348409-oxjd263z 233 125 cetuximab cetuximab NNP cord-348409-oxjd263z 233 126 mimotopes mimotope NNS cord-348409-oxjd263z 233 127 and and CC cord-348409-oxjd263z 233 128 biological biological JJ cord-348409-oxjd263z 233 129 properties property NNS cord-348409-oxjd263z 233 130 of of IN cord-348409-oxjd263z 233 131 induced induce VBN cord-348409-oxjd263z 233 132 anti anti JJ cord-348409-oxjd263z 233 133 - - JJ cord-348409-oxjd263z 233 134 epidermal epidermal JJ cord-348409-oxjd263z 233 135 growth growth NN cord-348409-oxjd263z 233 136 factor factor NN cord-348409-oxjd263z 233 137 receptor receptor NN cord-348409-oxjd263z 233 138 antibodies antibody NNS cord-348409-oxjd263z 233 139 Identification identification NN cord-348409-oxjd263z 233 140 and and CC cord-348409-oxjd263z 233 141 characterization characterization NN cord-348409-oxjd263z 233 142 of of IN cord-348409-oxjd263z 233 143 protective protective JJ cord-348409-oxjd263z 233 144 epitope epitope NN cord-348409-oxjd263z 233 145 of of IN cord-348409-oxjd263z 233 146 Trichinella trichinella NN cord-348409-oxjd263z 233 147 spiralis spiralis NN cord-348409-oxjd263z 233 148 paramyosin paramyosin NNP cord-348409-oxjd263z 233 149 Mimotopes Mimotopes NNP cord-348409-oxjd263z 233 150 selected select VBN cord-348409-oxjd263z 233 151 with with IN cord-348409-oxjd263z 233 152 neutralizing neutralize VBG cord-348409-oxjd263z 233 153 antibodies antibody NNS cord-348409-oxjd263z 233 154 against against IN cord-348409-oxjd263z 233 155 multiple multiple JJ cord-348409-oxjd263z 233 156 subtypes subtype NNS cord-348409-oxjd263z 233 157 of of IN cord-348409-oxjd263z 233 158 influenza influenza NN cord-348409-oxjd263z 233 159 A a DT cord-348409-oxjd263z 233 160 Induction Induction NNP cord-348409-oxjd263z 233 161 of of IN cord-348409-oxjd263z 233 162 humoral humoral JJ cord-348409-oxjd263z 233 163 immune immune JJ cord-348409-oxjd263z 233 164 response response NN cord-348409-oxjd263z 233 165 against against IN cord-348409-oxjd263z 233 166 Plasmodium Plasmodium NNP cord-348409-oxjd263z 233 167 falciparum falciparum NN cord-348409-oxjd263z 233 168 sporozoites sporozoite NNS cord-348409-oxjd263z 233 169 by by IN cord-348409-oxjd263z 233 170 immunization immunization NN cord-348409-oxjd263z 233 171 with with IN cord-348409-oxjd263z 233 172 a a DT cord-348409-oxjd263z 233 173 synthetic synthetic JJ cord-348409-oxjd263z 233 174 peptide peptide NN cord-348409-oxjd263z 233 175 mimotope mimotope NN cord-348409-oxjd263z 233 176 whose whose WP$ cord-348409-oxjd263z 233 177 sequence sequence NN cord-348409-oxjd263z 233 178 was be VBD cord-348409-oxjd263z 233 179 derived derive VBN cord-348409-oxjd263z 233 180 from from IN cord-348409-oxjd263z 233 181 screening screen VBG cord-348409-oxjd263z 233 182 a a DT cord-348409-oxjd263z 233 183 filamentous filamentous JJ cord-348409-oxjd263z 233 184 phage phage NN cord-348409-oxjd263z 233 185 epitope epitope NN cord-348409-oxjd263z 233 186 library library NN cord-348409-oxjd263z 233 187 High high JJ cord-348409-oxjd263z 233 188 - - HYPH cord-348409-oxjd263z 233 189 molecular molecular JJ cord-348409-oxjd263z 233 190 - - HYPH cord-348409-oxjd263z 233 191 weight weight NN cord-348409-oxjd263z 233 192 melanoma melanoma NN cord-348409-oxjd263z 233 193 - - HYPH cord-348409-oxjd263z 233 194 associated associate VBN cord-348409-oxjd263z 233 195 antigen antigen NN cord-348409-oxjd263z 233 196 mimotope mimotope NN cord-348409-oxjd263z 233 197 immunizations immunization NNS cord-348409-oxjd263z 233 198 induce induce VBP cord-348409-oxjd263z 233 199 antibodies antibody NNS cord-348409-oxjd263z 233 200 recognizing recognize VBG cord-348409-oxjd263z 233 201 melanoma melanoma NN cord-348409-oxjd263z 233 202 cells cell NNS cord-348409-oxjd263z 233 203 Differential differential JJ cord-348409-oxjd263z 233 204 immunogenicity immunogenicity NN cord-348409-oxjd263z 233 205 of of IN cord-348409-oxjd263z 233 206 two two CD cord-348409-oxjd263z 233 207 peptides peptide NNS cord-348409-oxjd263z 233 208 isolated isolate VBN cord-348409-oxjd263z 233 209 by by IN cord-348409-oxjd263z 233 210 high high JJ cord-348409-oxjd263z 233 211 molecular molecular JJ cord-348409-oxjd263z 233 212 weight weight NN cord-348409-oxjd263z 233 213 - - HYPH cord-348409-oxjd263z 233 214 melanoma melanoma NN cord-348409-oxjd263z 233 215 - - HYPH cord-348409-oxjd263z 233 216 associated associate VBN cord-348409-oxjd263z 233 217 antigen antigen NN cord-348409-oxjd263z 233 218 - - HYPH cord-348409-oxjd263z 233 219 specific specific JJ cord-348409-oxjd263z 233 220 monoclonal monoclonal JJ cord-348409-oxjd263z 233 221 antibodies antibody NNS cord-348409-oxjd263z 233 222 with with IN cord-348409-oxjd263z 233 223 different different JJ cord-348409-oxjd263z 233 224 affinities affinity NNS cord-348409-oxjd263z 233 225 Vaccination Vaccination NNP cord-348409-oxjd263z 233 226 with with IN cord-348409-oxjd263z 233 227 a a DT cord-348409-oxjd263z 233 228 human human JJ cord-348409-oxjd263z 233 229 high high JJ cord-348409-oxjd263z 233 230 molecular molecular JJ cord-348409-oxjd263z 233 231 weight weight NN cord-348409-oxjd263z 233 232 melanoma melanoma NN cord-348409-oxjd263z 233 233 - - HYPH cord-348409-oxjd263z 233 234 associated associate VBN cord-348409-oxjd263z 233 235 antigen antigen NN cord-348409-oxjd263z 233 236 mimotope mimotope NNP cord-348409-oxjd263z 233 237 induces induce VBZ cord-348409-oxjd263z 233 238 a a DT cord-348409-oxjd263z 233 239 humoral humoral JJ cord-348409-oxjd263z 233 240 response response NN cord-348409-oxjd263z 233 241 inhibiting inhibit VBG cord-348409-oxjd263z 233 242 melanoma melanoma NN cord-348409-oxjd263z 233 243 cell cell NN cord-348409-oxjd263z 233 244 growth growth NN cord-348409-oxjd263z 233 245 in in IN cord-348409-oxjd263z 233 246 vitro vitro FW cord-348409-oxjd263z 234 1 Targeting target VBG cord-348409-oxjd263z 234 2 melanoma melanoma NN cord-348409-oxjd263z 234 3 cells cell NNS cord-348409-oxjd263z 234 4 with with IN cord-348409-oxjd263z 234 5 human human JJ cord-348409-oxjd263z 234 6 high high JJ cord-348409-oxjd263z 234 7 molecular molecular JJ cord-348409-oxjd263z 234 8 weight weight NN cord-348409-oxjd263z 234 9 - - HYPH cord-348409-oxjd263z 234 10 melanoma melanoma NN cord-348409-oxjd263z 234 11 associated associate VBN cord-348409-oxjd263z 234 12 antigen antigen NN cord-348409-oxjd263z 234 13 - - HYPH cord-348409-oxjd263z 234 14 specific specific JJ cord-348409-oxjd263z 234 15 antibodies antibody NNS cord-348409-oxjd263z 234 16 elicited elicit VBN cord-348409-oxjd263z 234 17 by by IN cord-348409-oxjd263z 234 18 a a DT cord-348409-oxjd263z 234 19 peptide peptide NN cord-348409-oxjd263z 234 20 mimotope mimotope NN cord-348409-oxjd263z 234 21 : : : cord-348409-oxjd263z 235 1 functional functional JJ cord-348409-oxjd263z 235 2 effects effect NNS cord-348409-oxjd263z 235 3 Specificity Specificity NNP cord-348409-oxjd263z 235 4 of of IN cord-348409-oxjd263z 235 5 mimotopeinduced mimotopeinduced NNP cord-348409-oxjd263z 235 6 anti anti JJ cord-348409-oxjd263z 235 7 - - JJ cord-348409-oxjd263z 235 8 high high JJ cord-348409-oxjd263z 235 9 molecular molecular JJ cord-348409-oxjd263z 235 10 weight weight NN cord-348409-oxjd263z 235 11 - - HYPH cord-348409-oxjd263z 235 12 melanoma melanoma NN cord-348409-oxjd263z 235 13 associated associate VBN cord-348409-oxjd263z 235 14 antigen antigen NN cord-348409-oxjd263z 235 15 ( ( -LRB- cord-348409-oxjd263z 235 16 HMW HMW NNP cord-348409-oxjd263z 235 17 - - HYPH cord-348409-oxjd263z 235 18 MAA MAA NNP cord-348409-oxjd263z 235 19 ) ) -RRB- cord-348409-oxjd263z 235 20 antibodies antibody NNS cord-348409-oxjd263z 235 21 does do VBZ cord-348409-oxjd263z 235 22 not not RB cord-348409-oxjd263z 235 23 ensure ensure VB cord-348409-oxjd263z 235 24 biological biological JJ cord-348409-oxjd263z 235 25 activity activity NN cord-348409-oxjd263z 236 1 A a DT cord-348409-oxjd263z 236 2 mimotope mimotope NN cord-348409-oxjd263z 236 3 peptide peptide NN cord-348409-oxjd263z 236 4 - - HYPH cord-348409-oxjd263z 236 5 based base VBN cord-348409-oxjd263z 236 6 anti anti JJ cord-348409-oxjd263z 236 7 - - JJ cord-348409-oxjd263z 236 8 cancer cancer JJ cord-348409-oxjd263z 236 9 vaccine vaccine NN cord-348409-oxjd263z 236 10 selected select VBN cord-348409-oxjd263z 236 11 by by IN cord-348409-oxjd263z 236 12 BAT BAT NNP cord-348409-oxjd263z 236 13 monoclonal monoclonal JJ cord-348409-oxjd263z 236 14 antibody antibody NN cord-348409-oxjd263z 236 15 Peptide Peptide NNP cord-348409-oxjd263z 236 16 mimotopes mimotope NNS cord-348409-oxjd263z 236 17 recognized recognize VBN cord-348409-oxjd263z 236 18 by by IN cord-348409-oxjd263z 236 19 antibodies antibody NNS cord-348409-oxjd263z 236 20 cetuximab cetuximab NNP cord-348409-oxjd263z 236 21 and and CC cord-348409-oxjd263z 236 22 matuzumab matuzumab NNS cord-348409-oxjd263z 236 23 induce induce VBP cord-348409-oxjd263z 236 24 a a DT cord-348409-oxjd263z 236 25 functionally functionally RB cord-348409-oxjd263z 236 26 equivalent equivalent JJ cord-348409-oxjd263z 236 27 anti anti JJ cord-348409-oxjd263z 236 28 - - JJ cord-348409-oxjd263z 236 29 EGFR egfr JJ cord-348409-oxjd263z 236 30 immune immune JJ cord-348409-oxjd263z 236 31 response response NN cord-348409-oxjd263z 237 1 Mimotope mimotope NN cord-348409-oxjd263z 237 2 vaccination vaccination NN cord-348409-oxjd263z 237 3 for for IN cord-348409-oxjd263z 237 4 epitope epitope NN cord-348409-oxjd263z 237 5 - - HYPH cord-348409-oxjd263z 237 6 specific specific JJ cord-348409-oxjd263z 237 7 induction induction NN cord-348409-oxjd263z 237 8 of of IN cord-348409-oxjd263z 237 9 anti anti JJ cord-348409-oxjd263z 237 10 - - JJ cord-348409-oxjd263z 237 11 VEGF VEGF NNP cord-348409-oxjd263z 237 12 antibodies antibody NNS cord-348409-oxjd263z 237 13 Peptide Peptide NNP cord-348409-oxjd263z 237 14 mimics mimic VBZ cord-348409-oxjd263z 237 15 of of IN cord-348409-oxjd263z 237 16 the the DT cord-348409-oxjd263z 237 17 group group NN cord-348409-oxjd263z 237 18 B b NN cord-348409-oxjd263z 237 19 meningococcal meningococcal JJ cord-348409-oxjd263z 237 20 capsule capsule NN cord-348409-oxjd263z 237 21 induce induce VB cord-348409-oxjd263z 237 22 bactericidal bactericidal JJ cord-348409-oxjd263z 237 23 and and CC cord-348409-oxjd263z 237 24 protective protective JJ cord-348409-oxjd263z 237 25 antibodies antibody NNS cord-348409-oxjd263z 237 26 after after IN cord-348409-oxjd263z 237 27 immunization immunization NN cord-348409-oxjd263z 237 28 Peptides peptide NNS cord-348409-oxjd263z 237 29 selected select VBN cord-348409-oxjd263z 237 30 from from IN cord-348409-oxjd263z 237 31 a a DT cord-348409-oxjd263z 237 32 phage phage NN cord-348409-oxjd263z 237 33 display display NN cord-348409-oxjd263z 237 34 library library NN cord-348409-oxjd263z 237 35 with with IN cord-348409-oxjd263z 237 36 an an DT cord-348409-oxjd263z 237 37 HIV HIV NNP cord-348409-oxjd263z 237 38 - - HYPH cord-348409-oxjd263z 237 39 neutralizing neutralize VBG cord-348409-oxjd263z 237 40 antibody antibody NN cord-348409-oxjd263z 237 41 elicit elicit VB cord-348409-oxjd263z 237 42 antibodies antibody NNS cord-348409-oxjd263z 237 43 to to IN cord-348409-oxjd263z 237 44 HIV HIV NNP cord-348409-oxjd263z 237 45 gp120 gp120 NNP cord-348409-oxjd263z 237 46 in in IN cord-348409-oxjd263z 237 47 rabbits rabbit NNS cord-348409-oxjd263z 237 48 , , , cord-348409-oxjd263z 237 49 but but CC cord-348409-oxjd263z 237 50 not not RB cord-348409-oxjd263z 237 51 to to IN cord-348409-oxjd263z 237 52 the the DT cord-348409-oxjd263z 237 53 same same JJ cord-348409-oxjd263z 237 54 epitope epitope NN cord-348409-oxjd263z 237 55 Protective protective JJ cord-348409-oxjd263z 237 56 immune immune JJ cord-348409-oxjd263z 237 57 responses response NNS cord-348409-oxjd263z 237 58 induced induce VBN cord-348409-oxjd263z 237 59 by by IN cord-348409-oxjd263z 237 60 the the DT cord-348409-oxjd263z 237 61 immunization immunization NN cord-348409-oxjd263z 237 62 of of IN cord-348409-oxjd263z 237 63 mice mouse NNS cord-348409-oxjd263z 237 64 with with IN cord-348409-oxjd263z 237 65 a a DT cord-348409-oxjd263z 237 66 recombinant recombinant JJ cord-348409-oxjd263z 237 67 bacteriophage bacteriophage NN cord-348409-oxjd263z 237 68 displaying display VBG cord-348409-oxjd263z 237 69 an an DT cord-348409-oxjd263z 237 70 epitope epitope NN cord-348409-oxjd263z 237 71 of of IN cord-348409-oxjd263z 237 72 the the DT cord-348409-oxjd263z 237 73 human human JJ cord-348409-oxjd263z 237 74 respiratory respiratory JJ cord-348409-oxjd263z 237 75 syncytial syncytial JJ cord-348409-oxjd263z 237 76 virus virus NN cord-348409-oxjd263z 237 77 Immunisation Immunisation NNP cord-348409-oxjd263z 237 78 with with IN cord-348409-oxjd263z 237 79 phage phage NN cord-348409-oxjd263z 237 80 displaying display VBG cord-348409-oxjd263z 237 81 peptides peptide NNS cord-348409-oxjd263z 237 82 representing represent VBG cord-348409-oxjd263z 237 83 single single JJ cord-348409-oxjd263z 237 84 epitopes epitope NNS cord-348409-oxjd263z 237 85 of of IN cord-348409-oxjd263z 237 86 the the DT cord-348409-oxjd263z 237 87 glycoprotein glycoprotein NN cord-348409-oxjd263z 237 88 G g NN cord-348409-oxjd263z 237 89 can can MD cord-348409-oxjd263z 237 90 give give VB cord-348409-oxjd263z 237 91 rise rise NN cord-348409-oxjd263z 237 92 to to IN cord-348409-oxjd263z 237 93 partial partial JJ cord-348409-oxjd263z 237 94 protective protective JJ cord-348409-oxjd263z 237 95 immunity immunity NN cord-348409-oxjd263z 237 96 to to IN cord-348409-oxjd263z 237 97 HSV-2 hsv-2 VB cord-348409-oxjd263z 237 98 Characterization characterization NN cord-348409-oxjd263z 237 99 of of IN cord-348409-oxjd263z 237 100 murine murine JJ cord-348409-oxjd263z 237 101 coronavirus coronavirus NN cord-348409-oxjd263z 237 102 neutralization neutralization NN cord-348409-oxjd263z 237 103 epitopes epitope NNS cord-348409-oxjd263z 237 104 with with IN cord-348409-oxjd263z 237 105 phage phage NN cord-348409-oxjd263z 237 106 - - HYPH cord-348409-oxjd263z 237 107 displayed display VBN cord-348409-oxjd263z 237 108 peptides peptide NNS cord-348409-oxjd263z 237 109 Prophylactic prophylactic JJ cord-348409-oxjd263z 237 110 vaccination vaccination NN cord-348409-oxjd263z 237 111 with with IN cord-348409-oxjd263z 237 112 phagedisplayed phagedisplayed NNP cord-348409-oxjd263z 237 113 epitope epitope NN cord-348409-oxjd263z 237 114 of of IN cord-348409-oxjd263z 237 115 C. C. NNP cord-348409-oxjd263z 237 116 albicans albican NNS cord-348409-oxjd263z 237 117 elicits elicit VBZ cord-348409-oxjd263z 237 118 protective protective JJ cord-348409-oxjd263z 237 119 immune immune JJ cord-348409-oxjd263z 237 120 responses response NNS cord-348409-oxjd263z 237 121 against against IN cord-348409-oxjd263z 237 122 systemic systemic JJ cord-348409-oxjd263z 237 123 candidiasis candidiasi NNS cord-348409-oxjd263z 237 124 in in IN cord-348409-oxjd263z 237 125 C57BL/6 C57BL/6 NNP cord-348409-oxjd263z 237 126 mice mouse NNS cord-348409-oxjd263z 237 127 Protective protective JJ cord-348409-oxjd263z 237 128 immune immune JJ cord-348409-oxjd263z 237 129 responses response NNS cord-348409-oxjd263z 237 130 against against IN cord-348409-oxjd263z 237 131 systemic systemic JJ cord-348409-oxjd263z 237 132 candidiasis candidiasi NNS cord-348409-oxjd263z 237 133 mediated mediate VBN cord-348409-oxjd263z 237 134 by by IN cord-348409-oxjd263z 237 135 phage phage NN cord-348409-oxjd263z 237 136 - - HYPH cord-348409-oxjd263z 237 137 displayed display VBN cord-348409-oxjd263z 237 138 specific specific JJ cord-348409-oxjd263z 237 139 epitope epitope NN cord-348409-oxjd263z 237 140 of of IN cord-348409-oxjd263z 237 141 Candida Candida NNP cord-348409-oxjd263z 237 142 albicans albican NNS cord-348409-oxjd263z 237 143 heat heat VBP cord-348409-oxjd263z 237 144 shock shock NN cord-348409-oxjd263z 237 145 protein protein NN cord-348409-oxjd263z 237 146 90 90 CD cord-348409-oxjd263z 237 147 in in IN cord-348409-oxjd263z 237 148 C57BL/6J C57BL/6J NNP cord-348409-oxjd263z 237 149 mice mouse NNS cord-348409-oxjd263z 237 150 Recombinant recombinant JJ cord-348409-oxjd263z 237 151 bacteriophage bacteriophage NN cord-348409-oxjd263z 237 152 - - HYPH cord-348409-oxjd263z 237 153 based base VBN cord-348409-oxjd263z 237 154 multiepitope multiepitope NN cord-348409-oxjd263z 237 155 vaccine vaccine NN cord-348409-oxjd263z 237 156 against against IN cord-348409-oxjd263z 237 157 Taenia Taenia NNP cord-348409-oxjd263z 237 158 solium solium NN cord-348409-oxjd263z 237 159 pig pig NN cord-348409-oxjd263z 237 160 cysticercosis cysticercosis NN cord-348409-oxjd263z 237 161 Schistosoma Schistosoma NNP cord-348409-oxjd263z 237 162 japonicum japonicum NN cord-348409-oxjd263z 237 163 : : : cord-348409-oxjd263z 237 164 isolation isolation NN cord-348409-oxjd263z 237 165 and and CC cord-348409-oxjd263z 237 166 identification identification NN cord-348409-oxjd263z 237 167 of of IN cord-348409-oxjd263z 237 168 peptides peptide NNS cord-348409-oxjd263z 237 169 mimicking mimic VBG cord-348409-oxjd263z 237 170 ferritin ferritin NN cord-348409-oxjd263z 237 171 epitopes epitope NNS cord-348409-oxjd263z 237 172 from from IN cord-348409-oxjd263z 237 173 phage phage NN cord-348409-oxjd263z 237 174 display display NN cord-348409-oxjd263z 237 175 library library NN cord-348409-oxjd263z 237 176 Protective protective JJ cord-348409-oxjd263z 237 177 immunity immunity NN cord-348409-oxjd263z 237 178 induced induce VBN cord-348409-oxjd263z 237 179 by by IN cord-348409-oxjd263z 237 180 phage phage NN cord-348409-oxjd263z 237 181 displayed display VBN cord-348409-oxjd263z 237 182 mitochondrial mitochondrial JJ cord-348409-oxjd263z 237 183 related relate VBN cord-348409-oxjd263z 237 184 peptides peptide NNS cord-348409-oxjd263z 237 185 of of IN cord-348409-oxjd263z 237 186 Schistosoma Schistosoma NNP cord-348409-oxjd263z 237 187 japonicum japonicum NN cord-348409-oxjd263z 237 188 Induction Induction NNP cord-348409-oxjd263z 237 189 of of IN cord-348409-oxjd263z 237 190 immunity immunity NN cord-348409-oxjd263z 237 191 in in IN cord-348409-oxjd263z 237 192 sheep sheep NN cord-348409-oxjd263z 237 193 to to IN cord-348409-oxjd263z 237 194 Fasciola Fasciola NNP cord-348409-oxjd263z 237 195 hepatica hepatica NNP cord-348409-oxjd263z 237 196 with with IN cord-348409-oxjd263z 237 197 mimotopes mimotopes NNP cord-348409-oxjd263z 237 198 of of IN cord-348409-oxjd263z 237 199 cathepsin cathepsin NNP cord-348409-oxjd263z 237 200 L L NNP cord-348409-oxjd263z 237 201 selected select VBN cord-348409-oxjd263z 237 202 from from IN cord-348409-oxjd263z 237 203 a a DT cord-348409-oxjd263z 237 204 phage phage NN cord-348409-oxjd263z 237 205 display display NN cord-348409-oxjd263z 237 206 library library NN cord-348409-oxjd263z 237 207 Trichinella trichinella NN cord-348409-oxjd263z 237 208 spiralis spiralis NN cord-348409-oxjd263z 237 209 : : : cord-348409-oxjd263z 237 210 characterization characterization NN cord-348409-oxjd263z 237 211 of of IN cord-348409-oxjd263z 237 212 phagedisplayed phagedisplayed JJ cord-348409-oxjd263z 237 213 specific specific JJ cord-348409-oxjd263z 237 214 epitopes epitope NNS cord-348409-oxjd263z 237 215 and and CC cord-348409-oxjd263z 237 216 their -PRON- PRP$ cord-348409-oxjd263z 237 217 protective protective JJ cord-348409-oxjd263z 237 218 immunity immunity NN cord-348409-oxjd263z 237 219 in in IN cord-348409-oxjd263z 237 220 BALB/ BALB/ NNP cord-348409-oxjd263z 237 221 c c NNP cord-348409-oxjd263z 237 222 mice mice NN cord-348409-oxjd263z 237 223 Identification identification NN cord-348409-oxjd263z 237 224 of of IN cord-348409-oxjd263z 237 225 HIV HIV NNP cord-348409-oxjd263z 237 226 vaccine vaccine NN cord-348409-oxjd263z 237 227 candidate candidate NN cord-348409-oxjd263z 237 228 peptides peptide NNS cord-348409-oxjd263z 237 229 by by IN cord-348409-oxjd263z 237 230 screening screen VBG cord-348409-oxjd263z 237 231 random random JJ cord-348409-oxjd263z 237 232 phage phage NN cord-348409-oxjd263z 237 233 epitope epitope NN cord-348409-oxjd263z 237 234 libraries library NNS cord-348409-oxjd263z 237 235 Identification identification NN cord-348409-oxjd263z 237 236 and and CC cord-348409-oxjd263z 237 237 characterization characterization NN cord-348409-oxjd263z 237 238 of of IN cord-348409-oxjd263z 237 239 a a DT cord-348409-oxjd263z 237 240 peptide peptide NN cord-348409-oxjd263z 237 241 that that WDT cord-348409-oxjd263z 237 242 specifically specifically RB cord-348409-oxjd263z 237 243 binds bind VBZ cord-348409-oxjd263z 237 244 the the DT cord-348409-oxjd263z 237 245 human human NN cord-348409-oxjd263z 237 246 , , , cord-348409-oxjd263z 237 247 broadly broadly RB cord-348409-oxjd263z 237 248 neutralizing neutralize VBG cord-348409-oxjd263z 237 249 anti anti JJ cord-348409-oxjd263z 237 250 - - JJ cord-348409-oxjd263z 237 251 human human JJ cord-348409-oxjd263z 237 252 immunodeficiency immunodeficiency NN cord-348409-oxjd263z 237 253 virus virus NN cord-348409-oxjd263z 237 254 type type NN cord-348409-oxjd263z 237 255 1 1 CD cord-348409-oxjd263z 237 256 antibody antibody NN cord-348409-oxjd263z 237 257 b12 b12 NN cord-348409-oxjd263z 237 258 Immunogenicity Immunogenicity NNP cord-348409-oxjd263z 237 259 of of IN cord-348409-oxjd263z 237 260 HIV HIV NNP cord-348409-oxjd263z 237 261 type type NN cord-348409-oxjd263z 237 262 1 1 CD cord-348409-oxjd263z 238 1 gp120 gp120 NNP cord-348409-oxjd263z 238 2 CD4 CD4 NNP cord-348409-oxjd263z 238 3 binding bind VBG cord-348409-oxjd263z 238 4 site site NN cord-348409-oxjd263z 238 5 phage phage NN cord-348409-oxjd263z 238 6 mimotopes mimotopes NNP cord-348409-oxjd263z 239 1 A a DT cord-348409-oxjd263z 239 2 peptide peptide JJ cord-348409-oxjd263z 239 3 inhibitor inhibitor NN cord-348409-oxjd263z 239 4 of of IN cord-348409-oxjd263z 239 5 HIV-1 HIV-1 NNP cord-348409-oxjd263z 239 6 neutralizing neutralize VBG cord-348409-oxjd263z 239 7 antibody antibody NN cord-348409-oxjd263z 239 8 2G12 2g12 CD cord-348409-oxjd263z 239 9 is be VBZ cord-348409-oxjd263z 239 10 not not RB cord-348409-oxjd263z 239 11 a a DT cord-348409-oxjd263z 239 12 structural structural JJ cord-348409-oxjd263z 239 13 mimic mimic NN cord-348409-oxjd263z 239 14 of of IN cord-348409-oxjd263z 239 15 the the DT cord-348409-oxjd263z 239 16 natural natural JJ cord-348409-oxjd263z 239 17 carbohydrate carbohydrate NN cord-348409-oxjd263z 239 18 epitope epitope NN cord-348409-oxjd263z 239 19 on on IN cord-348409-oxjd263z 239 20 gp120 gp120 DT cord-348409-oxjd263z 239 21 Constrained constrain VBN cord-348409-oxjd263z 239 22 peptide peptide NN cord-348409-oxjd263z 239 23 models model NNS cord-348409-oxjd263z 239 24 from from IN cord-348409-oxjd263z 239 25 phage phage NN cord-348409-oxjd263z 239 26 display display NN cord-348409-oxjd263z 239 27 libraries library NNS cord-348409-oxjd263z 239 28 highlighting highlight VBG cord-348409-oxjd263z 239 29 the the DT cord-348409-oxjd263z 239 30 cognate cognate JJ cord-348409-oxjd263z 239 31 epitope epitope NN cord-348409-oxjd263z 239 32 - - HYPH cord-348409-oxjd263z 239 33 specific specific JJ cord-348409-oxjd263z 239 34 potential potential NN cord-348409-oxjd263z 239 35 of of IN cord-348409-oxjd263z 239 36 the the DT cord-348409-oxjd263z 239 37 anti anti JJ cord-348409-oxjd263z 239 38 - - NNP cord-348409-oxjd263z 239 39 HIV-1 HIV-1 NNP cord-348409-oxjd263z 239 40 mAb mAb HYPH cord-348409-oxjd263z 239 41 2F5 2f5 CD cord-348409-oxjd263z 239 42 Selection Selection NNP cord-348409-oxjd263z 239 43 of of IN cord-348409-oxjd263z 239 44 HIV HIV NNP cord-348409-oxjd263z 239 45 - - HYPH cord-348409-oxjd263z 239 46 specific specific JJ cord-348409-oxjd263z 239 47 immunogenic immunogenic JJ cord-348409-oxjd263z 239 48 epitopes epitope NNS cord-348409-oxjd263z 239 49 by by IN cord-348409-oxjd263z 239 50 screening screen VBG cord-348409-oxjd263z 239 51 random random JJ cord-348409-oxjd263z 239 52 peptide peptide JJ cord-348409-oxjd263z 239 53 libraries library NNS cord-348409-oxjd263z 239 54 with with IN cord-348409-oxjd263z 239 55 HIV-1-positive HIV-1-positive NNP cord-348409-oxjd263z 239 56 sera sera NNP cord-348409-oxjd263z 239 57 Collection Collection NNP cord-348409-oxjd263z 239 58 of of IN cord-348409-oxjd263z 239 59 phage phage NN cord-348409-oxjd263z 239 60 - - HYPH cord-348409-oxjd263z 239 61 peptide peptide NN cord-348409-oxjd263z 239 62 probes probe NNS cord-348409-oxjd263z 239 63 for for IN cord-348409-oxjd263z 239 64 HIV-1 HIV-1 NNP cord-348409-oxjd263z 239 65 immunodominant immunodominant NN cord-348409-oxjd263z 239 66 loop loop NN cord-348409-oxjd263z 239 67 - - HYPH cord-348409-oxjd263z 239 68 epitope epitope NN cord-348409-oxjd263z 239 69 Mimotopes Mimotopes NNPS cord-348409-oxjd263z 239 70 selected select VBN cord-348409-oxjd263z 239 71 with with IN cord-348409-oxjd263z 239 72 antibodies antibody NNS cord-348409-oxjd263z 239 73 from from IN cord-348409-oxjd263z 239 74 HIV-1-neutralizing hiv-1-neutralize VBG cord-348409-oxjd263z 239 75 long long JJ cord-348409-oxjd263z 239 76 - - HYPH cord-348409-oxjd263z 239 77 term term NN cord-348409-oxjd263z 239 78 non non JJ cord-348409-oxjd263z 239 79 - - JJ cord-348409-oxjd263z 239 80 progressor progressor JJ cord-348409-oxjd263z 239 81 plasma plasma NN cord-348409-oxjd263z 239 82 HIV-1 HIV-1 NNP cord-348409-oxjd263z 239 83 V3 V3 NNP cord-348409-oxjd263z 239 84 loop loop NN cord-348409-oxjd263z 239 85 crown crown NN cord-348409-oxjd263z 239 86 epitope epitope NN cord-348409-oxjd263z 239 87 - - HYPH cord-348409-oxjd263z 239 88 focused focus VBN cord-348409-oxjd263z 239 89 mimotope mimotope NN cord-348409-oxjd263z 239 90 selection selection NN cord-348409-oxjd263z 239 91 by by IN cord-348409-oxjd263z 239 92 patient patient JJ cord-348409-oxjd263z 239 93 serum serum NN cord-348409-oxjd263z 239 94 from from IN cord-348409-oxjd263z 239 95 random random JJ cord-348409-oxjd263z 239 96 phage phage NN cord-348409-oxjd263z 239 97 display display NN cord-348409-oxjd263z 239 98 libraries library NNS cord-348409-oxjd263z 239 99 : : : cord-348409-oxjd263z 239 100 implications implication NNS cord-348409-oxjd263z 239 101 for for IN cord-348409-oxjd263z 239 102 the the DT cord-348409-oxjd263z 239 103 epitope epitope NN cord-348409-oxjd263z 240 1 structural structural JJ cord-348409-oxjd263z 240 2 features feature VBZ cord-348409-oxjd263z 240 3 Protection Protection NNP cord-348409-oxjd263z 240 4 of of IN cord-348409-oxjd263z 240 5 rhesus rhesu NNS cord-348409-oxjd263z 240 6 macaques macaque NNS cord-348409-oxjd263z 240 7 against against IN cord-348409-oxjd263z 240 8 disease disease NN cord-348409-oxjd263z 240 9 progression progression NN cord-348409-oxjd263z 240 10 from from IN cord-348409-oxjd263z 240 11 pathogenic pathogenic JJ cord-348409-oxjd263z 240 12 SHIV-89.6PD shiv-89.6pd NN cord-348409-oxjd263z 240 13 by by IN cord-348409-oxjd263z 240 14 vaccination vaccination NN cord-348409-oxjd263z 240 15 with with IN cord-348409-oxjd263z 240 16 phage phage NN cord-348409-oxjd263z 240 17 - - HYPH cord-348409-oxjd263z 240 18 displayed display VBN cord-348409-oxjd263z 240 19 HIV-1 HIV-1 NNP cord-348409-oxjd263z 240 20 epitopes epitope NNS cord-348409-oxjd263z 240 21 Variable variable JJ cord-348409-oxjd263z 240 22 epitope epitope NN cord-348409-oxjd263z 240 23 library library NN cord-348409-oxjd263z 240 24 - - HYPH cord-348409-oxjd263z 240 25 based base VBN cord-348409-oxjd263z 240 26 vaccines vaccine NNS cord-348409-oxjd263z 240 27 : : : cord-348409-oxjd263z 241 1 shooting shoot VBG cord-348409-oxjd263z 241 2 moving move VBG cord-348409-oxjd263z 241 3 targets target NNS cord-348409-oxjd263z 241 4 Variable variable JJ cord-348409-oxjd263z 241 5 epitope epitope NN cord-348409-oxjd263z 241 6 libraries library NNS cord-348409-oxjd263z 241 7 : : : cord-348409-oxjd263z 241 8 new new JJ cord-348409-oxjd263z 241 9 vaccine vaccine NN cord-348409-oxjd263z 241 10 immunogens immunogen NNS cord-348409-oxjd263z 241 11 capable capable JJ cord-348409-oxjd263z 241 12 of of IN cord-348409-oxjd263z 241 13 inducing induce VBG cord-348409-oxjd263z 241 14 broad broad JJ cord-348409-oxjd263z 241 15 human human JJ cord-348409-oxjd263z 241 16 immunodeficiency immunodeficiency NN cord-348409-oxjd263z 241 17 virus virus NN cord-348409-oxjd263z 241 18 type type NN cord-348409-oxjd263z 241 19 1-neutralizing 1-neutralizing CD cord-348409-oxjd263z 241 20 antibody antibody NN cord-348409-oxjd263z 241 21 response response NN cord-348409-oxjd263z 241 22 A a DT cord-348409-oxjd263z 241 23 general general JJ cord-348409-oxjd263z 241 24 strategy strategy NN cord-348409-oxjd263z 241 25 to to TO cord-348409-oxjd263z 241 26 identify identify VB cord-348409-oxjd263z 241 27 mimotopes mimotope NNS cord-348409-oxjd263z 241 28 of of IN cord-348409-oxjd263z 241 29 pathological pathological JJ cord-348409-oxjd263z 241 30 antigens antigen NNS cord-348409-oxjd263z 241 31 using use VBG cord-348409-oxjd263z 241 32 only only RB cord-348409-oxjd263z 241 33 random random JJ cord-348409-oxjd263z 241 34 peptide peptide NN cord-348409-oxjd263z 241 35 libraries library NNS cord-348409-oxjd263z 241 36 and and CC cord-348409-oxjd263z 241 37 human human JJ cord-348409-oxjd263z 241 38 sera sera NNP cord-348409-oxjd263z 241 39 Induction Induction NNP cord-348409-oxjd263z 241 40 of of IN cord-348409-oxjd263z 241 41 hepatitis hepatitis NNP cord-348409-oxjd263z 241 42 B B NNP cord-348409-oxjd263z 241 43 virus virus NN cord-348409-oxjd263z 241 44 - - HYPH cord-348409-oxjd263z 241 45 specific specific JJ cord-348409-oxjd263z 241 46 cytotoxic cytotoxic JJ cord-348409-oxjd263z 241 47 T t NN cord-348409-oxjd263z 241 48 lymphocytes lymphocyte NNS cord-348409-oxjd263z 241 49 response response NN cord-348409-oxjd263z 241 50 in in IN cord-348409-oxjd263z 241 51 vivo vivo NN cord-348409-oxjd263z 241 52 by by IN cord-348409-oxjd263z 242 1 filamentous filamentous JJ cord-348409-oxjd263z 242 2 phage phage NN cord-348409-oxjd263z 242 3 display display NN cord-348409-oxjd263z 242 4 vaccine vaccine NN cord-348409-oxjd263z 242 5 Phage Phage NNP cord-348409-oxjd263z 242 6 display display NN cord-348409-oxjd263z 242 7 for for IN cord-348409-oxjd263z 242 8 sitespecific sitespecific JJ cord-348409-oxjd263z 242 9 immunization immunization NN cord-348409-oxjd263z 242 10 and and CC cord-348409-oxjd263z 242 11 characterization characterization NN cord-348409-oxjd263z 242 12 of of IN cord-348409-oxjd263z 242 13 high high JJ cord-348409-oxjd263z 242 14 - - HYPH cord-348409-oxjd263z 242 15 risk risk NN cord-348409-oxjd263z 242 16 human human JJ cord-348409-oxjd263z 242 17 papillomavirus papillomavirus NN cord-348409-oxjd263z 242 18 specific specific JJ cord-348409-oxjd263z 242 19 E7 E7 NNP cord-348409-oxjd263z 242 20 monoclonal monoclonal JJ cord-348409-oxjd263z 242 21 antibodies antibody NNS cord-348409-oxjd263z 242 22 Peptide Peptide NNP cord-348409-oxjd263z 242 23 mimotopes mimotope NNS cord-348409-oxjd263z 242 24 of of IN cord-348409-oxjd263z 242 25 rabies rabies NN cord-348409-oxjd263z 242 26 virus virus NN cord-348409-oxjd263z 242 27 glycoprotein glycoprotein NN cord-348409-oxjd263z 242 28 with with IN cord-348409-oxjd263z 242 29 immunogenic immunogenic JJ cord-348409-oxjd263z 242 30 activity activity NN cord-348409-oxjd263z 242 31 Immunogenicity immunogenicity NN cord-348409-oxjd263z 242 32 and and CC cord-348409-oxjd263z 242 33 epitope epitope NN cord-348409-oxjd263z 242 34 mapping mapping NN cord-348409-oxjd263z 242 35 of of IN cord-348409-oxjd263z 242 36 foreign foreign JJ cord-348409-oxjd263z 242 37 sequences sequence NNS cord-348409-oxjd263z 242 38 via via IN cord-348409-oxjd263z 242 39 genetically genetically RB cord-348409-oxjd263z 242 40 engineered engineer VBN cord-348409-oxjd263z 242 41 filamentous filamentous JJ cord-348409-oxjd263z 242 42 phage phage NN cord-348409-oxjd263z 242 43 Multiple multiple JJ cord-348409-oxjd263z 242 44 display display NN cord-348409-oxjd263z 242 45 of of IN cord-348409-oxjd263z 242 46 foreign foreign JJ cord-348409-oxjd263z 242 47 peptides peptide NNS cord-348409-oxjd263z 242 48 on on IN cord-348409-oxjd263z 242 49 a a DT cord-348409-oxjd263z 242 50 filamentous filamentous JJ cord-348409-oxjd263z 242 51 bacteriophage bacteriophage NN cord-348409-oxjd263z 242 52 . . . cord-348409-oxjd263z 243 1 Peptides peptide NNS cord-348409-oxjd263z 243 2 from from IN cord-348409-oxjd263z 243 3 plasmodium plasmodium NN cord-348409-oxjd263z 243 4 falciparum falciparum NN cord-348409-oxjd263z 243 5 circumsporozoite circumsporozoite JJ cord-348409-oxjd263z 243 6 protein protein NN cord-348409-oxjd263z 243 7 as as IN cord-348409-oxjd263z 243 8 antigens antigen NNS cord-348409-oxjd263z 243 9 Random random JJ cord-348409-oxjd263z 243 10 - - HYPH cord-348409-oxjd263z 243 11 peptide peptide JJ cord-348409-oxjd263z 243 12 libraries library NNS cord-348409-oxjd263z 243 13 and and CC cord-348409-oxjd263z 243 14 antigenfragment antigenfragment JJ cord-348409-oxjd263z 243 15 libraries library NNS cord-348409-oxjd263z 243 16 for for IN cord-348409-oxjd263z 243 17 epitope epitope NN cord-348409-oxjd263z 243 18 mapping mapping NN cord-348409-oxjd263z 243 19 and and CC cord-348409-oxjd263z 243 20 the the DT cord-348409-oxjd263z 243 21 development development NN cord-348409-oxjd263z 243 22 of of IN cord-348409-oxjd263z 243 23 vaccines vaccine NNS cord-348409-oxjd263z 243 24 and and CC cord-348409-oxjd263z 243 25 diagnostics diagnostic NNS cord-348409-oxjd263z 243 26 Developing develop VBG cord-348409-oxjd263z 243 27 strategies strategy NNS cord-348409-oxjd263z 243 28 to to TO cord-348409-oxjd263z 243 29 enhance enhance VB cord-348409-oxjd263z 243 30 and and CC cord-348409-oxjd263z 243 31 focus focus VB cord-348409-oxjd263z 243 32 humoral humoral JJ cord-348409-oxjd263z 243 33 immune immune JJ cord-348409-oxjd263z 243 34 responses response NNS cord-348409-oxjd263z 243 35 using use VBG cord-348409-oxjd263z 243 36 filamentous filamentous JJ cord-348409-oxjd263z 243 37 phage phage NN cord-348409-oxjd263z 243 38 as as IN cord-348409-oxjd263z 243 39 a a DT cord-348409-oxjd263z 243 40 model model NN cord-348409-oxjd263z 243 41 antigen antigen NN cord-348409-oxjd263z 243 42 Phage Phage NNP cord-348409-oxjd263z 243 43 display display NN cord-348409-oxjd263z 243 44 of of IN cord-348409-oxjd263z 243 45 peptide peptide NN cord-348409-oxjd263z 243 46 epitopes epitope NNS cord-348409-oxjd263z 243 47 from from IN cord-348409-oxjd263z 243 48 HIV-1 HIV-1 NNP cord-348409-oxjd263z 243 49 elicits elicit VBZ cord-348409-oxjd263z 243 50 strong strong JJ cord-348409-oxjd263z 243 51 cytolytic cytolytic JJ cord-348409-oxjd263z 243 52 responses response NNS cord-348409-oxjd263z 244 1 Inexpensive inexpensive JJ cord-348409-oxjd263z 244 2 anticysticercosis anticysticercosis NN cord-348409-oxjd263z 244 3 vaccine vaccine NN cord-348409-oxjd263z 244 4 : : : cord-348409-oxjd263z 245 1 s3Pvac s3Pvac NNP cord-348409-oxjd263z 245 2 expressed express VBD cord-348409-oxjd263z 245 3 in in IN cord-348409-oxjd263z 245 4 heat heat NN cord-348409-oxjd263z 245 5 inactivated inactivate VBN cord-348409-oxjd263z 245 6 M13 M13 NNP cord-348409-oxjd263z 245 7 filamentous filamentous JJ cord-348409-oxjd263z 245 8 phage phage NN cord-348409-oxjd263z 245 9 proves prove VBZ cord-348409-oxjd263z 245 10 effective effective JJ cord-348409-oxjd263z 245 11 against against IN cord-348409-oxjd263z 245 12 naturally naturally RB cord-348409-oxjd263z 245 13 acquired acquire VBN cord-348409-oxjd263z 245 14 Taenia Taenia NNP cord-348409-oxjd263z 245 15 solium solium NN cord-348409-oxjd263z 245 16 porcine porcine NN cord-348409-oxjd263z 245 17 cysticercosis cysticercosis NN cord-348409-oxjd263z 246 1 The the DT cord-348409-oxjd263z 246 2 potential potential NN cord-348409-oxjd263z 246 3 of of IN cord-348409-oxjd263z 246 4 phage phage NN cord-348409-oxjd263z 246 5 display display NN cord-348409-oxjd263z 246 6 virions virion NNS cord-348409-oxjd263z 246 7 expressing express VBG cord-348409-oxjd263z 246 8 malignant malignant JJ cord-348409-oxjd263z 246 9 tumor tumor NN cord-348409-oxjd263z 246 10 specific specific JJ cord-348409-oxjd263z 246 11 antigen antigen NN cord-348409-oxjd263z 246 12 MAGE MAGE NNP cord-348409-oxjd263z 246 13 - - HYPH cord-348409-oxjd263z 246 14 A1 A1 NNP cord-348409-oxjd263z 246 15 epitope epitope NN cord-348409-oxjd263z 246 16 in in IN cord-348409-oxjd263z 246 17 murine murine JJ cord-348409-oxjd263z 246 18 model model NN cord-348409-oxjd263z 246 19 Phage Phage NNP cord-348409-oxjd263z 246 20 display display NN cord-348409-oxjd263z 246 21 particles particle NNS cord-348409-oxjd263z 246 22 expressing express VBG cord-348409-oxjd263z 246 23 tumor tumor NN cord-348409-oxjd263z 246 24 - - HYPH cord-348409-oxjd263z 246 25 specific specific JJ cord-348409-oxjd263z 246 26 antigens antigen NNS cord-348409-oxjd263z 246 27 induce induce VBP cord-348409-oxjd263z 246 28 preventive preventive JJ cord-348409-oxjd263z 246 29 and and CC cord-348409-oxjd263z 246 30 therapeutic therapeutic JJ cord-348409-oxjd263z 246 31 antitumor antitumor NN cord-348409-oxjd263z 246 32 immunity immunity NN cord-348409-oxjd263z 246 33 in in IN cord-348409-oxjd263z 246 34 murine murine JJ cord-348409-oxjd263z 246 35 p815 p815 NN cord-348409-oxjd263z 246 36 model model NN cord-348409-oxjd263z 247 1 A a DT cord-348409-oxjd263z 247 2 filamentous filamentous JJ cord-348409-oxjd263z 247 3 bacteriophage bacteriophage NN cord-348409-oxjd263z 247 4 targeted target VBN cord-348409-oxjd263z 247 5 to to IN cord-348409-oxjd263z 247 6 carcinoembryonic carcinoembryonic NNP cord-348409-oxjd263z 247 7 antigen antigen NN cord-348409-oxjd263z 247 8 induces induce VBZ cord-348409-oxjd263z 247 9 tumor tumor NN cord-348409-oxjd263z 247 10 regression regression NN cord-348409-oxjd263z 247 11 in in IN cord-348409-oxjd263z 247 12 mouse mouse NN cord-348409-oxjd263z 247 13 models model NNS cord-348409-oxjd263z 247 14 of of IN cord-348409-oxjd263z 247 15 colorectal colorectal JJ cord-348409-oxjd263z 247 16 cancer cancer NN cord-348409-oxjd263z 247 17 Active active JJ cord-348409-oxjd263z 247 18 immunization immunization NN cord-348409-oxjd263z 247 19 against against IN cord-348409-oxjd263z 247 20 Alzheimer Alzheimer NNP cord-348409-oxjd263z 247 21 's 's POS cord-348409-oxjd263z 247 22 beta beta JJ cord-348409-oxjd263z 247 23 - - HYPH cord-348409-oxjd263z 247 24 amyloid amyloid NN cord-348409-oxjd263z 247 25 peptide peptide NN cord-348409-oxjd263z 247 26 using use VBG cord-348409-oxjd263z 247 27 phage phage NN cord-348409-oxjd263z 247 28 display display NN cord-348409-oxjd263z 247 29 technology technology NN cord-348409-oxjd263z 247 30 Immunization Immunization NNP cord-348409-oxjd263z 247 31 against against IN cord-348409-oxjd263z 247 32 Alzheimer Alzheimer NNP cord-348409-oxjd263z 247 33 's 's POS cord-348409-oxjd263z 247 34 beta beta JJ cord-348409-oxjd263z 247 35 -amyloid -amyloid JJ cord-348409-oxjd263z 247 36 plaques plaque NNS cord-348409-oxjd263z 247 37 via via IN cord-348409-oxjd263z 247 38 EFRH EFRH NNP cord-348409-oxjd263z 247 39 phage phage NN cord-348409-oxjd263z 247 40 administration administration NN cord-348409-oxjd263z 247 41 Reduction reduction NN cord-348409-oxjd263z 247 42 of of IN cord-348409-oxjd263z 247 43 betaamyloid betaamyloid NN cord-348409-oxjd263z 247 44 plaques plaque NNS cord-348409-oxjd263z 247 45 in in IN cord-348409-oxjd263z 247 46 brain brain NN cord-348409-oxjd263z 247 47 of of IN cord-348409-oxjd263z 247 48 transgenic transgenic JJ cord-348409-oxjd263z 247 49 mouse mouse NN cord-348409-oxjd263z 247 50 model model NN cord-348409-oxjd263z 247 51 of of IN cord-348409-oxjd263z 247 52 Alzheimer Alzheimer NNP cord-348409-oxjd263z 247 53 's 's POS cord-348409-oxjd263z 247 54 disease disease NN cord-348409-oxjd263z 247 55 by by IN cord-348409-oxjd263z 247 56 EFRH EFRH NNP cord-348409-oxjd263z 247 57 - - HYPH cord-348409-oxjd263z 247 58 phage phage NN cord-348409-oxjd263z 247 59 immunization immunization NN cord-348409-oxjd263z 247 60 EFRH EFRH NNP cord-348409-oxjd263z 247 61 - - HYPH cord-348409-oxjd263z 247 62 phage phage NN cord-348409-oxjd263z 247 63 immunization immunization NN cord-348409-oxjd263z 247 64 of of IN cord-348409-oxjd263z 247 65 Alzheimer Alzheimer NNP cord-348409-oxjd263z 247 66 's 's POS cord-348409-oxjd263z 247 67 disease disease NN cord-348409-oxjd263z 247 68 animal animal NN cord-348409-oxjd263z 247 69 model model NN cord-348409-oxjd263z 247 70 improves improve VBZ cord-348409-oxjd263z 247 71 behavioral behavioral JJ cord-348409-oxjd263z 247 72 performance performance NN cord-348409-oxjd263z 247 73 in in IN cord-348409-oxjd263z 247 74 Morris Morris NNP cord-348409-oxjd263z 247 75 water water NN cord-348409-oxjd263z 247 76 maze maze NN cord-348409-oxjd263z 247 77 trials trial NNS cord-348409-oxjd263z 247 78 HIV-1 HIV-1 NNP cord-348409-oxjd263z 247 79 vaccine vaccine NN cord-348409-oxjd263z 247 80 strategies strategy NNS cord-348409-oxjd263z 247 81 utilizing utilize VBG cord-348409-oxjd263z 247 82 viral viral JJ cord-348409-oxjd263z 247 83 vectors vector NNS cord-348409-oxjd263z 247 84 including include VBG cord-348409-oxjd263z 247 85 antigen antigen NN cord-348409-oxjd263z 247 86 - - HYPH cord-348409-oxjd263z 247 87 displayed display VBN cord-348409-oxjd263z 247 88 inoviral inoviral NN cord-348409-oxjd263z 247 89 vectors vector NNS cord-348409-oxjd263z 247 90 HIV-1 HIV-1 NNP cord-348409-oxjd263z 247 91 neutralizing neutralize VBG cord-348409-oxjd263z 247 92 antibodies antibody NNS cord-348409-oxjd263z 247 93 : : : cord-348409-oxjd263z 247 94 understanding understand VBG cord-348409-oxjd263z 247 95 nature nature NN cord-348409-oxjd263z 247 96 's 's POS cord-348409-oxjd263z 247 97 pathways pathway NNS cord-348409-oxjd263z 247 98 Antibodies Antibodies NNPS cord-348409-oxjd263z 247 99 in in IN cord-348409-oxjd263z 247 100 HIV-1 HIV-1 NNP cord-348409-oxjd263z 247 101 vaccine vaccine NN cord-348409-oxjd263z 247 102 development development NN cord-348409-oxjd263z 247 103 and and CC cord-348409-oxjd263z 247 104 therapy therapy NN cord-348409-oxjd263z 247 105 Broadly broadly RB cord-348409-oxjd263z 247 106 neutralizing neutralize VBG cord-348409-oxjd263z 247 107 antibodies antibody NNS cord-348409-oxjd263z 247 108 and and CC cord-348409-oxjd263z 247 109 the the DT cord-348409-oxjd263z 247 110 search search NN cord-348409-oxjd263z 247 111 for for IN cord-348409-oxjd263z 247 112 an an DT cord-348409-oxjd263z 247 113 HIV-1 HIV-1 NNP cord-348409-oxjd263z 247 114 vaccine vaccine NN cord-348409-oxjd263z 247 115 : : : cord-348409-oxjd263z 247 116 the the DT cord-348409-oxjd263z 247 117 end end NN cord-348409-oxjd263z 247 118 of of IN cord-348409-oxjd263z 247 119 the the DT cord-348409-oxjd263z 247 120 beginning beginning NN cord-348409-oxjd263z 247 121 Profound Profound NNP cord-348409-oxjd263z 247 122 early early JJ cord-348409-oxjd263z 247 123 control control NN cord-348409-oxjd263z 247 124 of of IN cord-348409-oxjd263z 247 125 highly highly RB cord-348409-oxjd263z 247 126 pathogenic pathogenic JJ cord-348409-oxjd263z 247 127 SIV SIV NNP cord-348409-oxjd263z 247 128 by by IN cord-348409-oxjd263z 247 129 an an DT cord-348409-oxjd263z 247 130 effector effector NN cord-348409-oxjd263z 247 131 memory memory NN cord-348409-oxjd263z 247 132 T t NN cord-348409-oxjd263z 247 133 - - HYPH cord-348409-oxjd263z 247 134 cell cell NN cord-348409-oxjd263z 247 135 vaccine vaccine NN cord-348409-oxjd263z 247 136 Immune immune JJ cord-348409-oxjd263z 247 137 clearance clearance NN cord-348409-oxjd263z 247 138 of of IN cord-348409-oxjd263z 247 139 highly highly RB cord-348409-oxjd263z 247 140 pathogenic pathogenic JJ cord-348409-oxjd263z 247 141 SIV SIV NNP cord-348409-oxjd263z 247 142 infection infection NN cord-348409-oxjd263z 247 143 Inducing induce VBG cord-348409-oxjd263z 247 144 cross cross NN cord-348409-oxjd263z 247 145 - - JJ cord-348409-oxjd263z 247 146 clade clade JJ cord-348409-oxjd263z 247 147 neutralizing neutralize VBG cord-348409-oxjd263z 247 148 antibodies antibody NNS cord-348409-oxjd263z 247 149 against against IN cord-348409-oxjd263z 247 150 HIV-1 HIV-1 NNP cord-348409-oxjd263z 247 151 by by IN cord-348409-oxjd263z 247 152 immunofocusing immunofocuse VBG cord-348409-oxjd263z 247 153 Cardiolipin Cardiolipin NNP cord-348409-oxjd263z 247 154 polyspecific polyspecific NN cord-348409-oxjd263z 247 155 autoreactivity autoreactivity NN cord-348409-oxjd263z 247 156 in in IN cord-348409-oxjd263z 247 157 two two CD cord-348409-oxjd263z 247 158 broadly broadly RB cord-348409-oxjd263z 247 159 neutralizing neutralize VBG cord-348409-oxjd263z 247 160 HIV-1 HIV-1 NNP cord-348409-oxjd263z 247 161 antibodies antibody NNS cord-348409-oxjd263z 248 1 The the DT cord-348409-oxjd263z 248 2 role role NN cord-348409-oxjd263z 248 3 of of IN cord-348409-oxjd263z 248 4 antibody antibody NN cord-348409-oxjd263z 248 5 polyspecificity polyspecificity NN cord-348409-oxjd263z 248 6 and and CC cord-348409-oxjd263z 248 7 lipid lipid NN cord-348409-oxjd263z 248 8 reactivity reactivity NN cord-348409-oxjd263z 248 9 in in IN cord-348409-oxjd263z 248 10 binding binding NN cord-348409-oxjd263z 248 11 of of IN cord-348409-oxjd263z 248 12 broadly broadly RB cord-348409-oxjd263z 248 13 neutralizing neutralize VBG cord-348409-oxjd263z 248 14 anti anti JJ cord-348409-oxjd263z 248 15 - - JJ cord-348409-oxjd263z 248 16 HIV-1 hiv-1 JJ cord-348409-oxjd263z 248 17 envelope envelope NN cord-348409-oxjd263z 248 18 human human JJ cord-348409-oxjd263z 248 19 monoclonal monoclonal JJ cord-348409-oxjd263z 248 20 antibodies antibody NNS cord-348409-oxjd263z 248 21 2F5 2f5 CD cord-348409-oxjd263z 248 22 and and CC cord-348409-oxjd263z 248 23 4E10 4e10 CD cord-348409-oxjd263z 248 24 to to IN cord-348409-oxjd263z 248 25 glycoprotein glycoprotein NN cord-348409-oxjd263z 248 26 41 41 CD cord-348409-oxjd263z 248 27 membrane membrane NN cord-348409-oxjd263z 248 28 proximal proximal JJ cord-348409-oxjd263z 248 29 envelope envelope NN cord-348409-oxjd263z 248 30 epitopes epitope NNS cord-348409-oxjd263z 249 1 Specific specific JJ cord-348409-oxjd263z 249 2 phospholipid phospholipid NN cord-348409-oxjd263z 249 3 recognition recognition NN cord-348409-oxjd263z 249 4 by by IN cord-348409-oxjd263z 249 5 human human JJ cord-348409-oxjd263z 249 6 immunodeficiency immunodeficiency NN cord-348409-oxjd263z 249 7 virus virus NN cord-348409-oxjd263z 249 8 type-1 type-1 NN cord-348409-oxjd263z 249 9 neutralizing neutralize VBG cord-348409-oxjd263z 249 10 anti anti JJ cord-348409-oxjd263z 249 11 - - JJ cord-348409-oxjd263z 249 12 gp41 gp41 JJ cord-348409-oxjd263z 249 13 2F5 2f5 CD cord-348409-oxjd263z 249 14 antibody antibody NN cord-348409-oxjd263z 250 1 The the DT cord-348409-oxjd263z 250 2 broadly broadly RB cord-348409-oxjd263z 250 3 neutralizing neutralize VBG cord-348409-oxjd263z 250 4 anti anti JJ cord-348409-oxjd263z 250 5 - - JJ cord-348409-oxjd263z 250 6 human human JJ cord-348409-oxjd263z 250 7 immunodeficiency immunodeficiency NN cord-348409-oxjd263z 250 8 virus virus NN cord-348409-oxjd263z 250 9 type type NN cord-348409-oxjd263z 250 10 1 1 CD cord-348409-oxjd263z 250 11 antibody antibody NN cord-348409-oxjd263z 250 12 2G12 2g12 CD cord-348409-oxjd263z 250 13 recognizes recognize VBZ cord-348409-oxjd263z 250 14 a a DT cord-348409-oxjd263z 250 15 cluster cluster NN cord-348409-oxjd263z 250 16 of of IN cord-348409-oxjd263z 250 17 alpha1->2 alpha1->2 DT cord-348409-oxjd263z 250 18 mannose mannose NN cord-348409-oxjd263z 250 19 residues residue NNS cord-348409-oxjd263z 250 20 on on IN cord-348409-oxjd263z 250 21 the the DT cord-348409-oxjd263z 250 22 outer outer JJ cord-348409-oxjd263z 250 23 face face NN cord-348409-oxjd263z 250 24 of of IN cord-348409-oxjd263z 250 25 gp120 gp120 NNP cord-348409-oxjd263z 250 26 Antibody Antibody NNP cord-348409-oxjd263z 250 27 polyspecificity polyspecificity NN cord-348409-oxjd263z 250 28 and and CC cord-348409-oxjd263z 250 29 neutralization neutralization NN cord-348409-oxjd263z 250 30 of of IN cord-348409-oxjd263z 250 31 HIV-1 HIV-1 NNP cord-348409-oxjd263z 250 32 : : : cord-348409-oxjd263z 250 33 a a DT cord-348409-oxjd263z 250 34 hypothesis hypothesis NN cord-348409-oxjd263z 250 35 Immunocontraception immunocontraception NN cord-348409-oxjd263z 250 36 : : : cord-348409-oxjd263z 250 37 filamentous filamentous JJ cord-348409-oxjd263z 250 38 bacteriophage bacteriophage NN cord-348409-oxjd263z 250 39 as as IN cord-348409-oxjd263z 250 40 a a DT cord-348409-oxjd263z 250 41 platform platform NN cord-348409-oxjd263z 250 42 for for IN cord-348409-oxjd263z 250 43 vaccine vaccine NN cord-348409-oxjd263z 250 44 development development NN cord-348409-oxjd263z 251 1 The the DT cord-348409-oxjd263z 251 2 Nobel Nobel NNP cord-348409-oxjd263z 251 3 Prize Prize NNP cord-348409-oxjd263z 251 4 in in IN cord-348409-oxjd263z 251 5 chemistry chemistry NN cord-348409-oxjd263z 252 1 We -PRON- PRP cord-348409-oxjd263z 252 2 thank thank VBP cord-348409-oxjd263z 252 3 the the DT cord-348409-oxjd263z 252 4 University University NNP cord-348409-oxjd263z 252 5 of of IN cord-348409-oxjd263z 252 6 Cyprus Cyprus NNP cord-348409-oxjd263z 252 7 for for IN cord-348409-oxjd263z 252 8 its -PRON- PRP$ cord-348409-oxjd263z 252 9 support support NN cord-348409-oxjd263z 252 10 . . . cord-348409-oxjd263z 253 1 The the DT cord-348409-oxjd263z 253 2 authors author NNS cord-348409-oxjd263z 253 3 have have VBP cord-348409-oxjd263z 253 4 no no DT cord-348409-oxjd263z 253 5 relevant relevant JJ cord-348409-oxjd263z 253 6 affiliations affiliation NNS cord-348409-oxjd263z 253 7 or or CC cord-348409-oxjd263z 253 8 financial financial JJ cord-348409-oxjd263z 253 9 involvement involvement NN cord-348409-oxjd263z 253 10 with with IN cord-348409-oxjd263z 253 11 any any DT cord-348409-oxjd263z 253 12 organization organization NN cord-348409-oxjd263z 253 13 or or CC cord-348409-oxjd263z 253 14 entity entity NN cord-348409-oxjd263z 253 15 with with IN cord-348409-oxjd263z 253 16 a a DT cord-348409-oxjd263z 253 17 financial financial JJ cord-348409-oxjd263z 253 18 interest interest NN cord-348409-oxjd263z 253 19 in in IN cord-348409-oxjd263z 253 20 or or CC cord-348409-oxjd263z 253 21 financial financial JJ cord-348409-oxjd263z 253 22 conflict conflict NN cord-348409-oxjd263z 253 23 with with IN cord-348409-oxjd263z 253 24 the the DT cord-348409-oxjd263z 253 25 subject subject JJ cord-348409-oxjd263z 253 26 matter matter NN cord-348409-oxjd263z 253 27 or or CC cord-348409-oxjd263z 253 28 materials material NNS cord-348409-oxjd263z 253 29 discussed discuss VBN cord-348409-oxjd263z 253 30 in in IN cord-348409-oxjd263z 253 31 the the DT cord-348409-oxjd263z 253 32 manuscript manuscript NN cord-348409-oxjd263z 253 33 . . . cord-348409-oxjd263z 254 1 This this DT cord-348409-oxjd263z 254 2 includes include VBZ cord-348409-oxjd263z 254 3 employment employment NN cord-348409-oxjd263z 254 4 , , , cord-348409-oxjd263z 254 5 consultancies consultancy NNS cord-348409-oxjd263z 254 6 , , , cord-348409-oxjd263z 254 7 honoraria honorarium NNS cord-348409-oxjd263z 254 8 , , , cord-348409-oxjd263z 254 9 stock stock NN cord-348409-oxjd263z 254 10 ownership ownership NN cord-348409-oxjd263z 254 11 or or CC cord-348409-oxjd263z 254 12 options option NNS cord-348409-oxjd263z 254 13 , , , cord-348409-oxjd263z 254 14 expert expert JJ cord-348409-oxjd263z 254 15 testimony testimony NN cord-348409-oxjd263z 254 16 , , , cord-348409-oxjd263z 254 17 grants grant NNS cord-348409-oxjd263z 254 18 or or CC cord-348409-oxjd263z 254 19 patents patent NNS cord-348409-oxjd263z 254 20 received receive VBN cord-348409-oxjd263z 254 21 or or CC cord-348409-oxjd263z 254 22 pending pende VBG cord-348409-oxjd263z 254 23 , , , cord-348409-oxjd263z 254 24 or or CC cord-348409-oxjd263z 254 25 royalties royalty NNS cord-348409-oxjd263z 254 26 . . . cord-348409-oxjd263z 255 1 Peer peer NN cord-348409-oxjd263z 255 2 reviewers reviewer NNS cord-348409-oxjd263z 255 3 on on IN cord-348409-oxjd263z 255 4 this this DT cord-348409-oxjd263z 255 5 manuscript manuscript NN cord-348409-oxjd263z 255 6 have have VBP cord-348409-oxjd263z 255 7 no no DT cord-348409-oxjd263z 255 8 relevant relevant JJ cord-348409-oxjd263z 255 9 financial financial JJ cord-348409-oxjd263z 255 10 or or CC cord-348409-oxjd263z 255 11 other other JJ cord-348409-oxjd263z 255 12 relationships relationship NNS cord-348409-oxjd263z 255 13 to to TO cord-348409-oxjd263z 255 14 disclose disclose VB cord-348409-oxjd263z 255 15 . . . cord-348409-oxjd263z 255 16 _SP