id sid tid token lemma pos cord-349011-kxhpdvri 1 1 key key NNP cord-349011-kxhpdvri 1 2 : : : cord-349011-kxhpdvri 1 3 cord-349011-kxhpdvri cord-349011-kxhpdvri CD cord-349011-kxhpdvri 1 4 authors author NNS cord-349011-kxhpdvri 1 5 : : : cord-349011-kxhpdvri 1 6 Grandvaux Grandvaux NNP cord-349011-kxhpdvri 1 7 , , , cord-349011-kxhpdvri 1 8 Nathalie Nathalie NNP cord-349011-kxhpdvri 1 9 ; ; : cord-349011-kxhpdvri 1 10 McCormick McCormick NNP cord-349011-kxhpdvri 1 11 , , , cord-349011-kxhpdvri 1 12 Craig Craig NNP cord-349011-kxhpdvri 1 13 title title NN cord-349011-kxhpdvri 1 14 : : : cord-349011-kxhpdvri 2 1 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 2 2 : : : cord-349011-kxhpdvri 3 1 The the DT cord-349011-kxhpdvri 3 2 2nd 2nd JJ cord-349011-kxhpdvri 3 3 Symposium Symposium NNP cord-349011-kxhpdvri 3 4 of of IN cord-349011-kxhpdvri 3 5 the the DT cord-349011-kxhpdvri 3 6 Canadian Canadian NNP cord-349011-kxhpdvri 3 7 Society Society NNP cord-349011-kxhpdvri 3 8 for for IN cord-349011-kxhpdvri 3 9 Virology Virology NNP cord-349011-kxhpdvri 3 10 date date NN cord-349011-kxhpdvri 3 11 : : : cord-349011-kxhpdvri 3 12 2019 2019 CD cord-349011-kxhpdvri 3 13 - - HYPH cord-349011-kxhpdvri 3 14 01 01 CD cord-349011-kxhpdvri 3 15 - - SYM cord-349011-kxhpdvri 3 16 18 18 CD cord-349011-kxhpdvri 3 17 journal journal NN cord-349011-kxhpdvri 3 18 : : : cord-349011-kxhpdvri 4 1 Viruses virus NNS cord-349011-kxhpdvri 4 2 DOI DOI NNP cord-349011-kxhpdvri 4 3 : : : cord-349011-kxhpdvri 5 1 10.3390 10.3390 CD cord-349011-kxhpdvri 5 2 / / SYM cord-349011-kxhpdvri 5 3 v11010079 v11010079 NNP cord-349011-kxhpdvri 5 4 sha sha NNP cord-349011-kxhpdvri 5 5 : : : cord-349011-kxhpdvri 6 1 9685fb039a5be9e5466be1ee3b0f38a5dd7cc217 9685fb039a5be9e5466be1ee3b0f38a5dd7cc217 CD cord-349011-kxhpdvri 6 2 doc_id doc_id CD cord-349011-kxhpdvri 6 3 : : : cord-349011-kxhpdvri 6 4 349011 349011 CD cord-349011-kxhpdvri 6 5 cord_uid cord_uid NNS cord-349011-kxhpdvri 6 6 : : : cord-349011-kxhpdvri 6 7 kxhpdvri kxhpdvri NNP cord-349011-kxhpdvri 7 1 The the DT cord-349011-kxhpdvri 7 2 2nd 2nd JJ cord-349011-kxhpdvri 7 3 Symposium Symposium NNP cord-349011-kxhpdvri 7 4 of of IN cord-349011-kxhpdvri 7 5 the the DT cord-349011-kxhpdvri 7 6 Canadian Canadian NNP cord-349011-kxhpdvri 7 7 Society Society NNP cord-349011-kxhpdvri 7 8 for for IN cord-349011-kxhpdvri 7 9 Virology Virology NNP cord-349011-kxhpdvri 7 10 ( ( -LRB- cord-349011-kxhpdvri 7 11 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 7 12 ) ) -RRB- cord-349011-kxhpdvri 7 13 was be VBD cord-349011-kxhpdvri 7 14 held hold VBN cord-349011-kxhpdvri 7 15 in in IN cord-349011-kxhpdvri 7 16 June June NNP cord-349011-kxhpdvri 7 17 2018 2018 CD cord-349011-kxhpdvri 7 18 in in IN cord-349011-kxhpdvri 7 19 Halifax Halifax NNP cord-349011-kxhpdvri 7 20 , , , cord-349011-kxhpdvri 7 21 Nova Nova NNP cord-349011-kxhpdvri 7 22 Scotia Scotia NNP cord-349011-kxhpdvri 7 23 , , , cord-349011-kxhpdvri 7 24 Canada Canada NNP cord-349011-kxhpdvri 7 25 , , , cord-349011-kxhpdvri 7 26 as as IN cord-349011-kxhpdvri 7 27 a a DT cord-349011-kxhpdvri 7 28 featured feature VBN cord-349011-kxhpdvri 7 29 event event NN cord-349011-kxhpdvri 7 30 marking mark VBG cord-349011-kxhpdvri 7 31 the the DT cord-349011-kxhpdvri 7 32 200th 200th JJ cord-349011-kxhpdvri 7 33 anniversary anniversary NN cord-349011-kxhpdvri 7 34 of of IN cord-349011-kxhpdvri 7 35 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 7 36 University University NNP cord-349011-kxhpdvri 7 37 . . . cord-349011-kxhpdvri 8 1 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 8 2 attracted attract VBD cord-349011-kxhpdvri 8 3 175 175 CD cord-349011-kxhpdvri 8 4 attendees attendee NNS cord-349011-kxhpdvri 8 5 from from IN cord-349011-kxhpdvri 8 6 across across IN cord-349011-kxhpdvri 8 7 Canada Canada NNP cord-349011-kxhpdvri 8 8 and and CC cord-349011-kxhpdvri 8 9 around around IN cord-349011-kxhpdvri 8 10 the the DT cord-349011-kxhpdvri 8 11 world world NN cord-349011-kxhpdvri 8 12 , , , cord-349011-kxhpdvri 8 13 more more RBR cord-349011-kxhpdvri 8 14 than than IN cord-349011-kxhpdvri 8 15 double double PDT cord-349011-kxhpdvri 8 16 the the DT cord-349011-kxhpdvri 8 17 number number NN cord-349011-kxhpdvri 8 18 that that WDT cord-349011-kxhpdvri 8 19 attended attend VBD cord-349011-kxhpdvri 8 20 the the DT cord-349011-kxhpdvri 8 21 first first JJ cord-349011-kxhpdvri 8 22 CSV csv NN cord-349011-kxhpdvri 8 23 symposium symposium NN cord-349011-kxhpdvri 8 24 two two CD cord-349011-kxhpdvri 8 25 years year NNS cord-349011-kxhpdvri 8 26 earlier early RBR cord-349011-kxhpdvri 8 27 . . . cord-349011-kxhpdvri 9 1 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 9 2 provided provide VBD cord-349011-kxhpdvri 9 3 a a DT cord-349011-kxhpdvri 9 4 forum forum NN cord-349011-kxhpdvri 9 5 to to TO cord-349011-kxhpdvri 9 6 discuss discuss VB cord-349011-kxhpdvri 9 7 a a DT cord-349011-kxhpdvri 9 8 wide wide JJ cord-349011-kxhpdvri 9 9 range range NN cord-349011-kxhpdvri 9 10 of of IN cord-349011-kxhpdvri 9 11 topics topic NNS cord-349011-kxhpdvri 9 12 in in IN cord-349011-kxhpdvri 9 13 virology virology NN cord-349011-kxhpdvri 9 14 including include VBG cord-349011-kxhpdvri 9 15 human human JJ cord-349011-kxhpdvri 9 16 , , , cord-349011-kxhpdvri 9 17 veterinary veterinary JJ cord-349011-kxhpdvri 9 18 , , , cord-349011-kxhpdvri 9 19 plant plant NN cord-349011-kxhpdvri 9 20 , , , cord-349011-kxhpdvri 9 21 and and CC cord-349011-kxhpdvri 9 22 microbial microbial JJ cord-349011-kxhpdvri 9 23 pathogens pathogen NNS cord-349011-kxhpdvri 9 24 . . . cord-349011-kxhpdvri 10 1 Invited invite VBN cord-349011-kxhpdvri 10 2 keynote keynote JJ cord-349011-kxhpdvri 10 3 speakers speaker NNS cord-349011-kxhpdvri 10 4 included include VBD cord-349011-kxhpdvri 10 5 David David NNP cord-349011-kxhpdvri 10 6 Kelvin Kelvin NNP cord-349011-kxhpdvri 10 7 ( ( -LRB- cord-349011-kxhpdvri 10 8 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 10 9 University University NNP cord-349011-kxhpdvri 10 10 and and CC cord-349011-kxhpdvri 10 11 Shantou Shantou NNP cord-349011-kxhpdvri 10 12 University University NNP cord-349011-kxhpdvri 10 13 Medical Medical NNP cord-349011-kxhpdvri 10 14 College College NNP cord-349011-kxhpdvri 10 15 ) ) -RRB- cord-349011-kxhpdvri 10 16 who who WP cord-349011-kxhpdvri 10 17 provided provide VBD cord-349011-kxhpdvri 10 18 a a DT cord-349011-kxhpdvri 10 19 historical historical JJ cord-349011-kxhpdvri 10 20 perspective perspective NN cord-349011-kxhpdvri 10 21 on on IN cord-349011-kxhpdvri 10 22 influenza influenza NN cord-349011-kxhpdvri 10 23 on on IN cord-349011-kxhpdvri 10 24 the the DT cord-349011-kxhpdvri 10 25 100th 100th JJ cord-349011-kxhpdvri 10 26 anniversary anniversary NN cord-349011-kxhpdvri 10 27 of of IN cord-349011-kxhpdvri 10 28 the the DT cord-349011-kxhpdvri 10 29 1918 1918 CD cord-349011-kxhpdvri 10 30 pandemic pandemic NN cord-349011-kxhpdvri 10 31 ; ; : cord-349011-kxhpdvri 10 32 Sylvain Sylvain NNP cord-349011-kxhpdvri 10 33 Moineau Moineau NNP cord-349011-kxhpdvri 10 34 ( ( -LRB- cord-349011-kxhpdvri 10 35 Université Université NNP cord-349011-kxhpdvri 10 36 Laval Laval NNP cord-349011-kxhpdvri 10 37 ) ) -RRB- cord-349011-kxhpdvri 10 38 who who WP cord-349011-kxhpdvri 10 39 described describe VBD cord-349011-kxhpdvri 10 40 CRISPR CRISPR NNP cord-349011-kxhpdvri 10 41 - - HYPH cord-349011-kxhpdvri 10 42 Cas Cas NNP cord-349011-kxhpdvri 10 43 systems system NNS cord-349011-kxhpdvri 10 44 and and CC cord-349011-kxhpdvri 10 45 anti anti JJ cord-349011-kxhpdvri 10 46 - - JJ cord-349011-kxhpdvri 10 47 CRISPR crispr JJ cord-349011-kxhpdvri 10 48 proteins protein NNS cord-349011-kxhpdvri 10 49 in in IN cord-349011-kxhpdvri 10 50 warfare warfare NN cord-349011-kxhpdvri 10 51 between between IN cord-349011-kxhpdvri 10 52 bacteriophages bacteriophage NNS cord-349011-kxhpdvri 10 53 and and CC cord-349011-kxhpdvri 10 54 their -PRON- PRP$ cord-349011-kxhpdvri 10 55 host host NN cord-349011-kxhpdvri 10 56 microbes microbe NNS cord-349011-kxhpdvri 10 57 ; ; : cord-349011-kxhpdvri 10 58 and and CC cord-349011-kxhpdvri 10 59 Kate Kate NNP cord-349011-kxhpdvri 10 60 O’Brien O’Brien NNP cord-349011-kxhpdvri 10 61 ( ( -LRB- cord-349011-kxhpdvri 10 62 then then RB cord-349011-kxhpdvri 10 63 from from IN cord-349011-kxhpdvri 10 64 Johns Johns NNP cord-349011-kxhpdvri 10 65 Hopkins Hopkins NNP cord-349011-kxhpdvri 10 66 University University NNP cord-349011-kxhpdvri 10 67 , , , cord-349011-kxhpdvri 10 68 now now RB cord-349011-kxhpdvri 10 69 relocated relocate VBN cord-349011-kxhpdvri 10 70 to to IN cord-349011-kxhpdvri 10 71 the the DT cord-349011-kxhpdvri 10 72 World World NNP cord-349011-kxhpdvri 10 73 Health Health NNP cord-349011-kxhpdvri 10 74 Organization Organization NNP cord-349011-kxhpdvri 10 75 where where WRB cord-349011-kxhpdvri 10 76 she -PRON- PRP cord-349011-kxhpdvri 10 77 is be VBZ cord-349011-kxhpdvri 10 78 Director Director NNP cord-349011-kxhpdvri 10 79 of of IN cord-349011-kxhpdvri 10 80 Immunization Immunization NNP cord-349011-kxhpdvri 10 81 , , , cord-349011-kxhpdvri 10 82 Vaccines Vaccines NNPS cord-349011-kxhpdvri 10 83 and and CC cord-349011-kxhpdvri 10 84 Biologicals Biologicals NNPS cord-349011-kxhpdvri 10 85 ) ) -RRB- cord-349011-kxhpdvri 10 86 , , , cord-349011-kxhpdvri 10 87 who who WP cord-349011-kxhpdvri 10 88 discussed discuss VBD cord-349011-kxhpdvri 10 89 the the DT cord-349011-kxhpdvri 10 90 underlying underlying JJ cord-349011-kxhpdvri 10 91 viral viral JJ cord-349011-kxhpdvri 10 92 etiology etiology NN cord-349011-kxhpdvri 10 93 for for IN cord-349011-kxhpdvri 10 94 pneumonia pneumonia NN cord-349011-kxhpdvri 10 95 in in IN cord-349011-kxhpdvri 10 96 the the DT cord-349011-kxhpdvri 10 97 developing develop VBG cord-349011-kxhpdvri 10 98 world world NN cord-349011-kxhpdvri 10 99 , , , cord-349011-kxhpdvri 10 100 and and CC cord-349011-kxhpdvri 10 101 the the DT cord-349011-kxhpdvri 10 102 evidence evidence NN cord-349011-kxhpdvri 10 103 for for IN cord-349011-kxhpdvri 10 104 respiratory respiratory JJ cord-349011-kxhpdvri 10 105 syncytial syncytial JJ cord-349011-kxhpdvri 10 106 virus virus NN cord-349011-kxhpdvri 10 107 ( ( -LRB- cord-349011-kxhpdvri 10 108 RSV RSV NNP cord-349011-kxhpdvri 10 109 ) ) -RRB- cord-349011-kxhpdvri 10 110 as as IN cord-349011-kxhpdvri 10 111 a a DT cord-349011-kxhpdvri 10 112 primary primary JJ cord-349011-kxhpdvri 10 113 cause cause NN cord-349011-kxhpdvri 10 114 . . . cord-349011-kxhpdvri 11 1 Reflecting reflect VBG cord-349011-kxhpdvri 11 2 a a DT cord-349011-kxhpdvri 11 3 strong strong JJ cord-349011-kxhpdvri 11 4 commitment commitment NN cord-349011-kxhpdvri 11 5 of of IN cord-349011-kxhpdvri 11 6 Canadian canadian JJ cord-349011-kxhpdvri 11 7 virologists virologist NNS cord-349011-kxhpdvri 11 8 to to IN cord-349011-kxhpdvri 11 9 science science NN cord-349011-kxhpdvri 11 10 communication communication NN cord-349011-kxhpdvri 11 11 , , , cord-349011-kxhpdvri 11 12 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 11 13 featured feature VBD cord-349011-kxhpdvri 11 14 the the DT cord-349011-kxhpdvri 11 15 launch launch NN cord-349011-kxhpdvri 11 16 of of IN cord-349011-kxhpdvri 11 17 Halifax Halifax NNP cord-349011-kxhpdvri 11 18 ’s ’s POS cord-349011-kxhpdvri 11 19 first first JJ cord-349011-kxhpdvri 11 20 annual annual JJ cord-349011-kxhpdvri 11 21 Soapbox Soapbox NNP cord-349011-kxhpdvri 11 22 Science Science NNP cord-349011-kxhpdvri 11 23 event event NN cord-349011-kxhpdvri 11 24 to to TO cord-349011-kxhpdvri 11 25 enable enable VB cord-349011-kxhpdvri 11 26 public public JJ cord-349011-kxhpdvri 11 27 engagement engagement NN cord-349011-kxhpdvri 11 28 with with IN cord-349011-kxhpdvri 11 29 female female JJ cord-349011-kxhpdvri 11 30 scientists scientist NNS cord-349011-kxhpdvri 11 31 , , , cord-349011-kxhpdvri 11 32 and and CC cord-349011-kxhpdvri 11 33 the the DT cord-349011-kxhpdvri 11 34 live live NN cord-349011-kxhpdvri 11 35 - - HYPH cord-349011-kxhpdvri 11 36 taping taping NN cord-349011-kxhpdvri 11 37 of of IN cord-349011-kxhpdvri 11 38 the the DT cord-349011-kxhpdvri 11 39 499th 499th JJ cord-349011-kxhpdvri 11 40 episode episode NN cord-349011-kxhpdvri 11 41 of of IN cord-349011-kxhpdvri 11 42 the the DT cord-349011-kxhpdvri 11 43 This This NNP cord-349011-kxhpdvri 11 44 Week Week NNP cord-349011-kxhpdvri 11 45 in in IN cord-349011-kxhpdvri 11 46 Virology Virology NNP cord-349011-kxhpdvri 11 47 ( ( -LRB- cord-349011-kxhpdvri 11 48 TWIV TWIV NNP cord-349011-kxhpdvri 11 49 ) ) -RRB- cord-349011-kxhpdvri 11 50 podcast podcast NNP cord-349011-kxhpdvri 11 51 , , , cord-349011-kxhpdvri 11 52 hosted host VBN cord-349011-kxhpdvri 11 53 by by IN cord-349011-kxhpdvri 11 54 Vincent Vincent NNP cord-349011-kxhpdvri 11 55 Racaniello Racaniello NNP cord-349011-kxhpdvri 11 56 ( ( -LRB- cord-349011-kxhpdvri 11 57 Columbia Columbia NNP cord-349011-kxhpdvri 11 58 University University NNP cord-349011-kxhpdvri 11 59 ) ) -RRB- cord-349011-kxhpdvri 11 60 and and CC cord-349011-kxhpdvri 11 61 science science NN cord-349011-kxhpdvri 11 62 writer writer NN cord-349011-kxhpdvri 11 63 Alan Alan NNP cord-349011-kxhpdvri 11 64 Dove Dove NNP cord-349011-kxhpdvri 11 65 . . . cord-349011-kxhpdvri 12 1 TWIV TWIV NNP cord-349011-kxhpdvri 12 2 featured feature VBD cord-349011-kxhpdvri 12 3 interviews interview NNS cord-349011-kxhpdvri 12 4 of of IN cord-349011-kxhpdvri 12 5 CSV csv NN cord-349011-kxhpdvri 12 6 co co NNS cord-349011-kxhpdvri 12 7 - - NNS cord-349011-kxhpdvri 12 8 founders founder NNS cord-349011-kxhpdvri 12 9 Nathalie Nathalie NNP cord-349011-kxhpdvri 12 10 Grandvaux Grandvaux NNP cord-349011-kxhpdvri 12 11 ( ( -LRB- cord-349011-kxhpdvri 12 12 Université Université NNP cord-349011-kxhpdvri 12 13 de de NNP cord-349011-kxhpdvri 12 14 Montréal Montréal NNP cord-349011-kxhpdvri 12 15 ) ) -RRB- cord-349011-kxhpdvri 12 16 and and CC cord-349011-kxhpdvri 12 17 Craig Craig NNP cord-349011-kxhpdvri 12 18 McCormick McCormick NNP cord-349011-kxhpdvri 12 19 ( ( -LRB- cord-349011-kxhpdvri 12 20 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 12 21 University University NNP cord-349011-kxhpdvri 12 22 ) ) -RRB- cord-349011-kxhpdvri 12 23 , , , cord-349011-kxhpdvri 12 24 who who WP cord-349011-kxhpdvri 12 25 discussed discuss VBD cord-349011-kxhpdvri 12 26 the the DT cord-349011-kxhpdvri 12 27 origins origin NNS cord-349011-kxhpdvri 12 28 and and CC cord-349011-kxhpdvri 12 29 objectives objective NNS cord-349011-kxhpdvri 12 30 of of IN cord-349011-kxhpdvri 12 31 the the DT cord-349011-kxhpdvri 12 32 new new JJ cord-349011-kxhpdvri 12 33 society society NN cord-349011-kxhpdvri 12 34 ; ; : cord-349011-kxhpdvri 12 35 Ryan Ryan NNP cord-349011-kxhpdvri 12 36 Noyce Noyce NNP cord-349011-kxhpdvri 12 37 ( ( -LRB- cord-349011-kxhpdvri 12 38 University University NNP cord-349011-kxhpdvri 12 39 of of IN cord-349011-kxhpdvri 12 40 Alberta Alberta NNP cord-349011-kxhpdvri 12 41 ) ) -RRB- cord-349011-kxhpdvri 12 42 , , , cord-349011-kxhpdvri 12 43 who who WP cord-349011-kxhpdvri 12 44 discussed discuss VBD cord-349011-kxhpdvri 12 45 technical technical JJ cord-349011-kxhpdvri 12 46 and and CC cord-349011-kxhpdvri 12 47 ethical ethical JJ cord-349011-kxhpdvri 12 48 considerations consideration NNS cord-349011-kxhpdvri 12 49 of of IN cord-349011-kxhpdvri 12 50 synthetic synthetic JJ cord-349011-kxhpdvri 12 51 virology virology NN cord-349011-kxhpdvri 12 52 ; ; : cord-349011-kxhpdvri 12 53 and and CC cord-349011-kxhpdvri 12 54 Kate Kate NNP cord-349011-kxhpdvri 12 55 O’Brien O’Brien NNP cord-349011-kxhpdvri 12 56 , , , cord-349011-kxhpdvri 12 57 who who WP cord-349011-kxhpdvri 12 58 discussed discuss VBD cord-349011-kxhpdvri 12 59 vaccines vaccine NNS cord-349011-kxhpdvri 12 60 and and CC cord-349011-kxhpdvri 12 61 global global JJ cord-349011-kxhpdvri 12 62 health health NN cord-349011-kxhpdvri 12 63 . . . cord-349011-kxhpdvri 13 1 Finally finally RB cord-349011-kxhpdvri 13 2 , , , cord-349011-kxhpdvri 13 3 because because IN cord-349011-kxhpdvri 13 4 CSV csv NN cord-349011-kxhpdvri 13 5 seeks seek VBZ cord-349011-kxhpdvri 13 6 to to TO cord-349011-kxhpdvri 13 7 provide provide VB cord-349011-kxhpdvri 13 8 a a DT cord-349011-kxhpdvri 13 9 better well JJR cord-349011-kxhpdvri 13 10 future future NN cord-349011-kxhpdvri 13 11 for for IN cord-349011-kxhpdvri 13 12 the the DT cord-349011-kxhpdvri 13 13 next next JJ cord-349011-kxhpdvri 13 14 generation generation NN cord-349011-kxhpdvri 13 15 of of IN cord-349011-kxhpdvri 13 16 Canadian canadian JJ cord-349011-kxhpdvri 13 17 virologists virologist NNS cord-349011-kxhpdvri 13 18 , , , cord-349011-kxhpdvri 13 19 the the DT cord-349011-kxhpdvri 13 20 symposium symposium NN cord-349011-kxhpdvri 13 21 featured feature VBD cord-349011-kxhpdvri 13 22 a a DT cord-349011-kxhpdvri 13 23 large large JJ cord-349011-kxhpdvri 13 24 number number NN cord-349011-kxhpdvri 13 25 of of IN cord-349011-kxhpdvri 13 26 oral oral JJ cord-349011-kxhpdvri 13 27 and and CC cord-349011-kxhpdvri 13 28 poster poster NN cord-349011-kxhpdvri 13 29 presentations presentation NNS cord-349011-kxhpdvri 13 30 from from IN cord-349011-kxhpdvri 13 31 trainees trainee NNS cord-349011-kxhpdvri 13 32 and and CC cord-349011-kxhpdvri 13 33 closed close VBD cord-349011-kxhpdvri 13 34 with with IN cord-349011-kxhpdvri 13 35 the the DT cord-349011-kxhpdvri 13 36 awarding awarding NN cord-349011-kxhpdvri 13 37 of of IN cord-349011-kxhpdvri 13 38 presentation presentation NN cord-349011-kxhpdvri 13 39 prizes prize NNS cord-349011-kxhpdvri 13 40 to to IN cord-349011-kxhpdvri 13 41 trainees trainee NNS cord-349011-kxhpdvri 13 42 , , , cord-349011-kxhpdvri 13 43 followed follow VBN cord-349011-kxhpdvri 13 44 by by IN cord-349011-kxhpdvri 13 45 a a DT cord-349011-kxhpdvri 13 46 tour tour NN cord-349011-kxhpdvri 13 47 of of IN cord-349011-kxhpdvri 13 48 the the DT cord-349011-kxhpdvri 13 49 Halifax Halifax NNP cord-349011-kxhpdvri 13 50 Citadel Citadel NNP cord-349011-kxhpdvri 13 51 National National NNP cord-349011-kxhpdvri 13 52 Historic Historic NNP cord-349011-kxhpdvri 13 53 Site Site NNP cord-349011-kxhpdvri 13 54 and and CC cord-349011-kxhpdvri 13 55 an an DT cord-349011-kxhpdvri 13 56 evening evening NN cord-349011-kxhpdvri 13 57 of of IN cord-349011-kxhpdvri 13 58 entertainment entertainment NN cord-349011-kxhpdvri 13 59 at at IN cord-349011-kxhpdvri 13 60 the the DT cord-349011-kxhpdvri 13 61 historic historic JJ cord-349011-kxhpdvri 13 62 Alexander Alexander NNP cord-349011-kxhpdvri 13 63 Keith Keith NNP cord-349011-kxhpdvri 13 64 ’s ’s POS cord-349011-kxhpdvri 13 65 Brewery Brewery NNP cord-349011-kxhpdvri 13 66 . . . cord-349011-kxhpdvri 14 1 The the DT cord-349011-kxhpdvri 14 2 Canadian Canadian NNP cord-349011-kxhpdvri 14 3 Society Society NNP cord-349011-kxhpdvri 14 4 for for IN cord-349011-kxhpdvri 14 5 Virology Virology NNP cord-349011-kxhpdvri 14 6 ( ( -LRB- cord-349011-kxhpdvri 14 7 CSV csv NN cord-349011-kxhpdvri 14 8 ) ) -RRB- cord-349011-kxhpdvri 14 9 was be VBD cord-349011-kxhpdvri 14 10 founded found VBN cord-349011-kxhpdvri 14 11 in in IN cord-349011-kxhpdvri 14 12 2016 2016 CD cord-349011-kxhpdvri 14 13 to to TO cord-349011-kxhpdvri 14 14 provide provide VB cord-349011-kxhpdvri 14 15 support support NN cord-349011-kxhpdvri 14 16 for for IN cord-349011-kxhpdvri 14 17 the the DT cord-349011-kxhpdvri 14 18 Canadian canadian JJ cord-349011-kxhpdvri 14 19 virology virology NN cord-349011-kxhpdvri 14 20 research research NN cord-349011-kxhpdvri 14 21 community community NN cord-349011-kxhpdvri 14 22 , , , cord-349011-kxhpdvri 14 23 including include VBG cord-349011-kxhpdvri 14 24 basic basic JJ cord-349011-kxhpdvri 14 25 , , , cord-349011-kxhpdvri 14 26 clinical clinical JJ cord-349011-kxhpdvri 14 27 , , , cord-349011-kxhpdvri 14 28 government government NN cord-349011-kxhpdvri 14 29 , , , cord-349011-kxhpdvri 14 30 and and CC cord-349011-kxhpdvri 14 31 industry industry NN cord-349011-kxhpdvri 14 32 researchers researcher NNS cord-349011-kxhpdvri 14 33 working work VBG cord-349011-kxhpdvri 14 34 on on IN cord-349011-kxhpdvri 14 35 a a DT cord-349011-kxhpdvri 14 36 broad broad JJ cord-349011-kxhpdvri 14 37 range range NN cord-349011-kxhpdvri 14 38 of of IN cord-349011-kxhpdvri 14 39 viruses virus NNS cord-349011-kxhpdvri 14 40 . . . cord-349011-kxhpdvri 15 1 To to TO cord-349011-kxhpdvri 15 2 launch launch VB cord-349011-kxhpdvri 15 3 the the DT cord-349011-kxhpdvri 15 4 new new JJ cord-349011-kxhpdvri 15 5 society society NN cord-349011-kxhpdvri 15 6 , , , cord-349011-kxhpdvri 15 7 CSV CSV NNP cord-349011-kxhpdvri 15 8 planned plan VBD cord-349011-kxhpdvri 15 9 a a DT cord-349011-kxhpdvri 15 10 satellite satellite NN cord-349011-kxhpdvri 15 11 workshop workshop NN cord-349011-kxhpdvri 15 12 in in IN cord-349011-kxhpdvri 15 13 conjunction conjunction NN cord-349011-kxhpdvri 15 14 with with IN cord-349011-kxhpdvri 15 15 the the DT cord-349011-kxhpdvri 15 16 annual annual JJ cord-349011-kxhpdvri 15 17 American American NNP cord-349011-kxhpdvri 15 18 Society Society NNP cord-349011-kxhpdvri 15 19 for for IN cord-349011-kxhpdvri 15 20 Virology Virology NNP cord-349011-kxhpdvri 15 21 ( ( -LRB- cord-349011-kxhpdvri 15 22 ASV ASV NNP cord-349011-kxhpdvri 15 23 ) ) -RRB- cord-349011-kxhpdvri 15 24 meeting meeting NN cord-349011-kxhpdvri 15 25 in in IN cord-349011-kxhpdvri 15 26 Blacksburg Blacksburg NNP cord-349011-kxhpdvri 15 27 , , , cord-349011-kxhpdvri 15 28 Virginia Virginia NNP cord-349011-kxhpdvri 15 29 in in IN cord-349011-kxhpdvri 15 30 June June NNP cord-349011-kxhpdvri 15 31 2016 2016 CD cord-349011-kxhpdvri 15 32 , , , cord-349011-kxhpdvri 15 33 which which WDT cord-349011-kxhpdvri 15 34 was be VBD cord-349011-kxhpdvri 15 35 supported support VBN cord-349011-kxhpdvri 15 36 by by IN cord-349011-kxhpdvri 15 37 then then RB cord-349011-kxhpdvri 15 38 - - HYPH cord-349011-kxhpdvri 15 39 ASV ASV NNP cord-349011-kxhpdvri 15 40 president president NN cord-349011-kxhpdvri 15 41 and and CC cord-349011-kxhpdvri 15 42 ex ex JJ cord-349011-kxhpdvri 15 43 - - JJ cord-349011-kxhpdvri 15 44 pat pat JJ cord-349011-kxhpdvri 15 45 Canadian Canadian NNP cord-349011-kxhpdvri 15 46 Dr. Dr. NNP cord-349011-kxhpdvri 15 47 Grant Grant NNP cord-349011-kxhpdvri 15 48 McFadden McFadden NNP cord-349011-kxhpdvri 15 49 [ [ -LRB- cord-349011-kxhpdvri 15 50 1 1 CD cord-349011-kxhpdvri 15 51 ] ] -RRB- cord-349011-kxhpdvri 15 52 . . . cord-349011-kxhpdvri 15 53 _SP cord-349011-kxhpdvri 16 1 The the DT cord-349011-kxhpdvri 16 2 symposium symposium NN cord-349011-kxhpdvri 16 3 opened open VBD cord-349011-kxhpdvri 16 4 with with IN cord-349011-kxhpdvri 16 5 a a DT cord-349011-kxhpdvri 16 6 keynote keynote JJ cord-349011-kxhpdvri 16 7 lecture lecture NN cord-349011-kxhpdvri 16 8 from from IN cord-349011-kxhpdvri 16 9 Dr. Dr. NNP cord-349011-kxhpdvri 16 10 David David NNP cord-349011-kxhpdvri 16 11 Kelvin Kelvin NNP cord-349011-kxhpdvri 16 12 ( ( -LRB- cord-349011-kxhpdvri 16 13 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 16 14 University University NNP cord-349011-kxhpdvri 16 15 and and CC cord-349011-kxhpdvri 16 16 Shantou Shantou NNP cord-349011-kxhpdvri 16 17 University University NNP cord-349011-kxhpdvri 16 18 Medical Medical NNP cord-349011-kxhpdvri 16 19 College College NNP cord-349011-kxhpdvri 16 20 ) ) -RRB- cord-349011-kxhpdvri 16 21 who who WP cord-349011-kxhpdvri 16 22 provided provide VBD cord-349011-kxhpdvri 16 23 a a DT cord-349011-kxhpdvri 16 24 historical historical JJ cord-349011-kxhpdvri 16 25 perspective perspective NN cord-349011-kxhpdvri 16 26 on on IN cord-349011-kxhpdvri 16 27 influenza influenza NN cord-349011-kxhpdvri 16 28 on on IN cord-349011-kxhpdvri 16 29 the the DT cord-349011-kxhpdvri 16 30 100th 100th JJ cord-349011-kxhpdvri 16 31 anniversary anniversary NN cord-349011-kxhpdvri 16 32 of of IN cord-349011-kxhpdvri 16 33 the the DT cord-349011-kxhpdvri 16 34 1918 1918 CD cord-349011-kxhpdvri 16 35 pandemic pandemic NN cord-349011-kxhpdvri 16 36 . . . cord-349011-kxhpdvri 17 1 Dr. Dr. NNP cord-349011-kxhpdvri 17 2 Kelvin Kelvin NNP cord-349011-kxhpdvri 17 3 shared share VBD cord-349011-kxhpdvri 17 4 anecdotes anecdote NNS cord-349011-kxhpdvri 17 5 from from IN cord-349011-kxhpdvri 17 6 the the DT cord-349011-kxhpdvri 17 7 1918 1918 CD cord-349011-kxhpdvri 17 8 pandemic pandemic NN cord-349011-kxhpdvri 17 9 and and CC cord-349011-kxhpdvri 17 10 described describe VBD cord-349011-kxhpdvri 17 11 how how WRB cord-349011-kxhpdvri 17 12 factors factor NNS cord-349011-kxhpdvri 17 13 such such JJ cord-349011-kxhpdvri 17 14 as as IN cord-349011-kxhpdvri 17 15 the the DT cord-349011-kxhpdvri 17 16 impact impact NN cord-349011-kxhpdvri 17 17 of of IN cord-349011-kxhpdvri 17 18 exposure exposure NN cord-349011-kxhpdvri 17 19 to to IN cord-349011-kxhpdvri 17 20 past past JJ cord-349011-kxhpdvri 17 21 circulating circulate VBG cord-349011-kxhpdvri 17 22 viruses virus NNS cord-349011-kxhpdvri 17 23 may may MD cord-349011-kxhpdvri 17 24 have have VB cord-349011-kxhpdvri 17 25 influenced influence VBN cord-349011-kxhpdvri 17 26 pathogenic pathogenic JJ cord-349011-kxhpdvri 17 27 outcome outcome NN cord-349011-kxhpdvri 17 28 to to IN cord-349011-kxhpdvri 17 29 the the DT cord-349011-kxhpdvri 17 30 1918 1918 CD cord-349011-kxhpdvri 17 31 pandemic pandemic NNP cord-349011-kxhpdvri 17 32 virus virus NN cord-349011-kxhpdvri 17 33 . . . cord-349011-kxhpdvri 18 1 He -PRON- PRP cord-349011-kxhpdvri 18 2 discussed discuss VBD cord-349011-kxhpdvri 18 3 the the DT cord-349011-kxhpdvri 18 4 circumstances circumstance NNS cord-349011-kxhpdvri 18 5 of of IN cord-349011-kxhpdvri 18 6 other other JJ cord-349011-kxhpdvri 18 7 influenza influenza NN cord-349011-kxhpdvri 18 8 pandemics pandemic NNS cord-349011-kxhpdvri 18 9 of of IN cord-349011-kxhpdvri 18 10 the the DT cord-349011-kxhpdvri 18 11 past past JJ cord-349011-kxhpdvri 18 12 two two CD cord-349011-kxhpdvri 18 13 centuries century NNS cord-349011-kxhpdvri 18 14 , , , cord-349011-kxhpdvri 18 15 and and CC cord-349011-kxhpdvri 18 16 the the DT cord-349011-kxhpdvri 18 17 unpredictable unpredictable JJ cord-349011-kxhpdvri 18 18 evolution evolution NN cord-349011-kxhpdvri 18 19 of of IN cord-349011-kxhpdvri 18 20 pandemic pandemic NN cord-349011-kxhpdvri 18 21 viruses virus NNS cord-349011-kxhpdvri 18 22 , , , cord-349011-kxhpdvri 18 23 whereby whereby WRB cord-349011-kxhpdvri 18 24 some some DT cord-349011-kxhpdvri 18 25 pandemic pandemic NN cord-349011-kxhpdvri 18 26 viruses virus NNS cord-349011-kxhpdvri 18 27 can can MD cord-349011-kxhpdvri 18 28 enter enter VB cord-349011-kxhpdvri 18 29 circulation circulation NN cord-349011-kxhpdvri 18 30 as as IN cord-349011-kxhpdvri 18 31 an an DT cord-349011-kxhpdvri 18 32 endemic endemic JJ cord-349011-kxhpdvri 18 33 virus virus NN cord-349011-kxhpdvri 18 34 , , , cord-349011-kxhpdvri 18 35 whereas whereas IN cord-349011-kxhpdvri 18 36 others other NNS cord-349011-kxhpdvri 18 37 , , , cord-349011-kxhpdvri 18 38 such such JJ cord-349011-kxhpdvri 18 39 as as IN cord-349011-kxhpdvri 18 40 the the DT cord-349011-kxhpdvri 18 41 1957 1957 CD cord-349011-kxhpdvri 18 42 H2N2 H2N2 NNP cord-349011-kxhpdvri 18 43 virus virus NN cord-349011-kxhpdvri 18 44 , , , cord-349011-kxhpdvri 18 45 can can MD cord-349011-kxhpdvri 18 46 disappear disappear VB cord-349011-kxhpdvri 18 47 entirely entirely RB cord-349011-kxhpdvri 18 48 . . . cord-349011-kxhpdvri 19 1 Lessons lesson NNS cord-349011-kxhpdvri 19 2 learned learn VBD cord-349011-kxhpdvri 19 3 from from IN cord-349011-kxhpdvri 19 4 the the DT cord-349011-kxhpdvri 19 5 study study NN cord-349011-kxhpdvri 19 6 of of IN cord-349011-kxhpdvri 19 7 these these DT cord-349011-kxhpdvri 19 8 viruses virus NNS cord-349011-kxhpdvri 19 9 could could MD cord-349011-kxhpdvri 19 10 be be VB cord-349011-kxhpdvri 19 11 applied apply VBN cord-349011-kxhpdvri 19 12 to to TO cord-349011-kxhpdvri 19 13 prevent prevent VB cord-349011-kxhpdvri 19 14 or or CC cord-349011-kxhpdvri 19 15 mitigate mitigate VB cord-349011-kxhpdvri 19 16 the the DT cord-349011-kxhpdvri 19 17 impact impact NN cord-349011-kxhpdvri 19 18 of of IN cord-349011-kxhpdvri 19 19 another another DT cord-349011-kxhpdvri 19 20 influenza influenza NN cord-349011-kxhpdvri 19 21 pandemic pandemic NN cord-349011-kxhpdvri 19 22 . . . cord-349011-kxhpdvri 20 1 The the DT cord-349011-kxhpdvri 20 2 2nd 2nd JJ cord-349011-kxhpdvri 20 3 keynote keynote JJ cord-349011-kxhpdvri 20 4 address address NN cord-349011-kxhpdvri 20 5 of of IN cord-349011-kxhpdvri 20 6 the the DT cord-349011-kxhpdvri 20 7 evening evening NN cord-349011-kxhpdvri 20 8 was be VBD cord-349011-kxhpdvri 20 9 delivered deliver VBN cord-349011-kxhpdvri 20 10 by by IN cord-349011-kxhpdvri 20 11 Dr. Dr. NNP cord-349011-kxhpdvri 20 12 Sylvain Sylvain NNP cord-349011-kxhpdvri 20 13 Moineau Moineau NNP cord-349011-kxhpdvri 20 14 ( ( -LRB- cord-349011-kxhpdvri 20 15 Université Université NNP cord-349011-kxhpdvri 20 16 Laval Laval NNP cord-349011-kxhpdvri 20 17 ) ) -RRB- cord-349011-kxhpdvri 20 18 who who WP cord-349011-kxhpdvri 20 19 transitioned transition VBD cord-349011-kxhpdvri 20 20 from from IN cord-349011-kxhpdvri 20 21 human human JJ cord-349011-kxhpdvri 20 22 hosts host NNS cord-349011-kxhpdvri 20 23 to to IN cord-349011-kxhpdvri 20 24 bacterial bacterial JJ cord-349011-kxhpdvri 20 25 hosts host NNS cord-349011-kxhpdvri 20 26 in in IN cord-349011-kxhpdvri 20 27 a a DT cord-349011-kxhpdvri 20 28 fascinating fascinating JJ cord-349011-kxhpdvri 20 29 talk talk NN cord-349011-kxhpdvri 20 30 about about IN cord-349011-kxhpdvri 20 31 CRISPR CRISPR NNP cord-349011-kxhpdvri 20 32 - - HYPH cord-349011-kxhpdvri 20 33 Cas Cas NNP cord-349011-kxhpdvri 20 34 antiviral antiviral JJ cord-349011-kxhpdvri 20 35 systems system NNS cord-349011-kxhpdvri 20 36 . . . cord-349011-kxhpdvri 21 1 Bacteria Bacteria NNS cord-349011-kxhpdvri 21 2 thrive thrive VBP cord-349011-kxhpdvri 21 3 in in IN cord-349011-kxhpdvri 21 4 virus virus NN cord-349011-kxhpdvri 21 5 - - HYPH cord-349011-kxhpdvri 21 6 rich rich JJ cord-349011-kxhpdvri 21 7 ecosystems ecosystem NNS cord-349011-kxhpdvri 21 8 by by IN cord-349011-kxhpdvri 21 9 using use VBG cord-349011-kxhpdvri 21 10 a a DT cord-349011-kxhpdvri 21 11 combination combination NN cord-349011-kxhpdvri 21 12 of of IN cord-349011-kxhpdvri 21 13 antiviral antiviral JJ cord-349011-kxhpdvri 21 14 defenses defense NNS cord-349011-kxhpdvri 21 15 including include VBG cord-349011-kxhpdvri 21 16 restriction restriction NN cord-349011-kxhpdvri 21 17 endonucleases endonuclease NNS cord-349011-kxhpdvri 21 18 and and CC cord-349011-kxhpdvri 21 19 CRISPR CRISPR NNP cord-349011-kxhpdvri 21 20 - - HYPH cord-349011-kxhpdvri 21 21 Cas Cas NNP cord-349011-kxhpdvri 21 22 enzymes enzyme NNS cord-349011-kxhpdvri 21 23 that that WDT cord-349011-kxhpdvri 21 24 effectively effectively RB cord-349011-kxhpdvri 21 25 act act VBP cord-349011-kxhpdvri 21 26 as as IN cord-349011-kxhpdvri 21 27 bacterial bacterial JJ cord-349011-kxhpdvri 21 28 intrinsic intrinsic JJ cord-349011-kxhpdvri 21 29 and and CC cord-349011-kxhpdvri 21 30 adaptive adaptive JJ cord-349011-kxhpdvri 21 31 immune immune JJ cord-349011-kxhpdvri 21 32 systems system NNS cord-349011-kxhpdvri 21 33 , , , cord-349011-kxhpdvri 21 34 respectively respectively RB cord-349011-kxhpdvri 21 35 . . . cord-349011-kxhpdvri 22 1 Dr. Dr. NNP cord-349011-kxhpdvri 22 2 Moineau Moineau NNP cord-349011-kxhpdvri 22 3 focused focus VBD cord-349011-kxhpdvri 22 4 on on IN cord-349011-kxhpdvri 22 5 bacterial bacterial JJ cord-349011-kxhpdvri 22 6 CRISPR CRISPR NNP cord-349011-kxhpdvri 22 7 - - HYPH cord-349011-kxhpdvri 22 8 Cas Cas NNP cord-349011-kxhpdvri 22 9 type type NN cord-349011-kxhpdvri 22 10 II II NNP cord-349011-kxhpdvri 22 11 systems system NNS cord-349011-kxhpdvri 22 12 that that WDT cord-349011-kxhpdvri 22 13 function function VBP cord-349011-kxhpdvri 22 14 by by IN cord-349011-kxhpdvri 22 15 archiving archive VBG cord-349011-kxhpdvri 22 16 short short JJ cord-349011-kxhpdvri 22 17 DNA dna NN cord-349011-kxhpdvri 22 18 " " `` cord-349011-kxhpdvri 22 19 spacers spacer NNS cord-349011-kxhpdvri 22 20 " " '' cord-349011-kxhpdvri 22 21 derived derive VBN cord-349011-kxhpdvri 22 22 from from IN cord-349011-kxhpdvri 22 23 invading invade VBG cord-349011-kxhpdvri 22 24 phage phage NN cord-349011-kxhpdvri 22 25 genomes genome NNS cord-349011-kxhpdvri 22 26 into into IN cord-349011-kxhpdvri 22 27 a a DT cord-349011-kxhpdvri 22 28 CRISPR CRISPR NNP cord-349011-kxhpdvri 22 29 array array NN cord-349011-kxhpdvri 22 30 in in IN cord-349011-kxhpdvri 22 31 their -PRON- PRP$ cord-349011-kxhpdvri 22 32 genome genome NN cord-349011-kxhpdvri 22 33 , , , cord-349011-kxhpdvri 22 34 providing provide VBG cord-349011-kxhpdvri 22 35 a a DT cord-349011-kxhpdvri 22 36 chronological chronological JJ cord-349011-kxhpdvri 22 37 record record NN cord-349011-kxhpdvri 22 38 of of IN cord-349011-kxhpdvri 22 39 past past JJ cord-349011-kxhpdvri 22 40 infections infection NNS cord-349011-kxhpdvri 22 41 . . . cord-349011-kxhpdvri 23 1 The the DT cord-349011-kxhpdvri 23 2 CRISPR CRISPR NNP cord-349011-kxhpdvri 23 3 array array NN cord-349011-kxhpdvri 23 4 is be VBZ cord-349011-kxhpdvri 23 5 then then RB cord-349011-kxhpdvri 23 6 transcribed transcribe VBN cord-349011-kxhpdvri 23 7 into into IN cord-349011-kxhpdvri 23 8 a a DT cord-349011-kxhpdvri 23 9 " " `` cord-349011-kxhpdvri 23 10 guide guide NN cord-349011-kxhpdvri 23 11 " " '' cord-349011-kxhpdvri 23 12 RNA RNA NNP cord-349011-kxhpdvri 23 13 that that IN cord-349011-kxhpdvri 23 14 associates associate NNS cord-349011-kxhpdvri 23 15 with with IN cord-349011-kxhpdvri 23 16 a a DT cord-349011-kxhpdvri 23 17 Cas Cas NNP cord-349011-kxhpdvri 23 18 _SP cord-349011-kxhpdvri 23 19 The the DT cord-349011-kxhpdvri 23 20 symposium symposium NN cord-349011-kxhpdvri 23 21 opened open VBN cord-349011-kxhpdvri 23 22 with with IN cord-349011-kxhpdvri 23 23 a a DT cord-349011-kxhpdvri 23 24 keynote keynote JJ cord-349011-kxhpdvri 23 25 lecture lecture NN cord-349011-kxhpdvri 23 26 from from IN cord-349011-kxhpdvri 23 27 Dr. Dr. NNP cord-349011-kxhpdvri 23 28 David David NNP cord-349011-kxhpdvri 23 29 Kelvin Kelvin NNP cord-349011-kxhpdvri 23 30 ( ( -LRB- cord-349011-kxhpdvri 23 31 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 23 32 University University NNP cord-349011-kxhpdvri 23 33 and and CC cord-349011-kxhpdvri 23 34 Shantou Shantou NNP cord-349011-kxhpdvri 23 35 University University NNP cord-349011-kxhpdvri 23 36 Medical Medical NNP cord-349011-kxhpdvri 23 37 College College NNP cord-349011-kxhpdvri 23 38 ) ) -RRB- cord-349011-kxhpdvri 23 39 who who WP cord-349011-kxhpdvri 23 40 provided provide VBD cord-349011-kxhpdvri 23 41 a a DT cord-349011-kxhpdvri 23 42 historical historical JJ cord-349011-kxhpdvri 23 43 perspective perspective NN cord-349011-kxhpdvri 23 44 on on IN cord-349011-kxhpdvri 23 45 influenza influenza NN cord-349011-kxhpdvri 23 46 on on IN cord-349011-kxhpdvri 23 47 the the DT cord-349011-kxhpdvri 23 48 100th 100th JJ cord-349011-kxhpdvri 23 49 anniversary anniversary NN cord-349011-kxhpdvri 23 50 of of IN cord-349011-kxhpdvri 23 51 the the DT cord-349011-kxhpdvri 23 52 1918 1918 CD cord-349011-kxhpdvri 23 53 pandemic pandemic NN cord-349011-kxhpdvri 23 54 . . . cord-349011-kxhpdvri 24 1 Dr. Dr. NNP cord-349011-kxhpdvri 24 2 Kelvin Kelvin NNP cord-349011-kxhpdvri 24 3 shared share VBD cord-349011-kxhpdvri 24 4 anecdotes anecdote NNS cord-349011-kxhpdvri 24 5 from from IN cord-349011-kxhpdvri 24 6 the the DT cord-349011-kxhpdvri 24 7 1918 1918 CD cord-349011-kxhpdvri 24 8 pandemic pandemic NN cord-349011-kxhpdvri 24 9 and and CC cord-349011-kxhpdvri 24 10 described describe VBD cord-349011-kxhpdvri 24 11 how how WRB cord-349011-kxhpdvri 24 12 factors factor NNS cord-349011-kxhpdvri 24 13 such such JJ cord-349011-kxhpdvri 24 14 as as IN cord-349011-kxhpdvri 24 15 the the DT cord-349011-kxhpdvri 24 16 impact impact NN cord-349011-kxhpdvri 24 17 of of IN cord-349011-kxhpdvri 24 18 exposure exposure NN cord-349011-kxhpdvri 24 19 to to IN cord-349011-kxhpdvri 24 20 past past JJ cord-349011-kxhpdvri 24 21 circulating circulate VBG cord-349011-kxhpdvri 24 22 viruses virus NNS cord-349011-kxhpdvri 24 23 may may MD cord-349011-kxhpdvri 24 24 have have VB cord-349011-kxhpdvri 24 25 influenced influence VBN cord-349011-kxhpdvri 24 26 pathogenic pathogenic JJ cord-349011-kxhpdvri 24 27 outcome outcome NN cord-349011-kxhpdvri 24 28 to to IN cord-349011-kxhpdvri 24 29 the the DT cord-349011-kxhpdvri 24 30 1918 1918 CD cord-349011-kxhpdvri 24 31 pandemic pandemic NNP cord-349011-kxhpdvri 24 32 virus virus NN cord-349011-kxhpdvri 24 33 . . . cord-349011-kxhpdvri 25 1 He -PRON- PRP cord-349011-kxhpdvri 25 2 discussed discuss VBD cord-349011-kxhpdvri 25 3 the the DT cord-349011-kxhpdvri 25 4 circumstances circumstance NNS cord-349011-kxhpdvri 25 5 of of IN cord-349011-kxhpdvri 25 6 other other JJ cord-349011-kxhpdvri 25 7 influenza influenza NN cord-349011-kxhpdvri 25 8 pandemics pandemic NNS cord-349011-kxhpdvri 25 9 of of IN cord-349011-kxhpdvri 25 10 the the DT cord-349011-kxhpdvri 25 11 past past JJ cord-349011-kxhpdvri 25 12 two two CD cord-349011-kxhpdvri 25 13 centuries century NNS cord-349011-kxhpdvri 25 14 , , , cord-349011-kxhpdvri 25 15 and and CC cord-349011-kxhpdvri 25 16 the the DT cord-349011-kxhpdvri 25 17 unpredictable unpredictable JJ cord-349011-kxhpdvri 25 18 evolution evolution NN cord-349011-kxhpdvri 25 19 of of IN cord-349011-kxhpdvri 25 20 pandemic pandemic NN cord-349011-kxhpdvri 25 21 viruses virus NNS cord-349011-kxhpdvri 25 22 , , , cord-349011-kxhpdvri 25 23 whereby whereby WRB cord-349011-kxhpdvri 25 24 some some DT cord-349011-kxhpdvri 25 25 pandemic pandemic NN cord-349011-kxhpdvri 25 26 viruses virus NNS cord-349011-kxhpdvri 25 27 can can MD cord-349011-kxhpdvri 25 28 enter enter VB cord-349011-kxhpdvri 25 29 circulation circulation NN cord-349011-kxhpdvri 25 30 as as IN cord-349011-kxhpdvri 25 31 an an DT cord-349011-kxhpdvri 25 32 endemic endemic JJ cord-349011-kxhpdvri 25 33 virus virus NN cord-349011-kxhpdvri 25 34 , , , cord-349011-kxhpdvri 25 35 whereas whereas IN cord-349011-kxhpdvri 25 36 others other NNS cord-349011-kxhpdvri 25 37 , , , cord-349011-kxhpdvri 25 38 such such JJ cord-349011-kxhpdvri 25 39 as as IN cord-349011-kxhpdvri 25 40 the the DT cord-349011-kxhpdvri 25 41 1957 1957 CD cord-349011-kxhpdvri 25 42 H2N2 H2N2 NNP cord-349011-kxhpdvri 25 43 virus virus NN cord-349011-kxhpdvri 25 44 , , , cord-349011-kxhpdvri 25 45 can can MD cord-349011-kxhpdvri 25 46 disappear disappear VB cord-349011-kxhpdvri 25 47 entirely entirely RB cord-349011-kxhpdvri 25 48 . . . cord-349011-kxhpdvri 26 1 Lessons lesson NNS cord-349011-kxhpdvri 26 2 learned learn VBD cord-349011-kxhpdvri 26 3 from from IN cord-349011-kxhpdvri 26 4 the the DT cord-349011-kxhpdvri 26 5 study study NN cord-349011-kxhpdvri 26 6 of of IN cord-349011-kxhpdvri 26 7 these these DT cord-349011-kxhpdvri 26 8 viruses virus NNS cord-349011-kxhpdvri 26 9 could could MD cord-349011-kxhpdvri 26 10 be be VB cord-349011-kxhpdvri 26 11 applied apply VBN cord-349011-kxhpdvri 26 12 to to TO cord-349011-kxhpdvri 26 13 prevent prevent VB cord-349011-kxhpdvri 26 14 or or CC cord-349011-kxhpdvri 26 15 mitigate mitigate VB cord-349011-kxhpdvri 26 16 the the DT cord-349011-kxhpdvri 26 17 impact impact NN cord-349011-kxhpdvri 26 18 of of IN cord-349011-kxhpdvri 26 19 another another DT cord-349011-kxhpdvri 26 20 influenza influenza NN cord-349011-kxhpdvri 26 21 pandemic pandemic NN cord-349011-kxhpdvri 26 22 . . . cord-349011-kxhpdvri 27 1 The the DT cord-349011-kxhpdvri 27 2 2nd 2nd JJ cord-349011-kxhpdvri 27 3 keynote keynote JJ cord-349011-kxhpdvri 27 4 address address NN cord-349011-kxhpdvri 27 5 of of IN cord-349011-kxhpdvri 27 6 the the DT cord-349011-kxhpdvri 27 7 evening evening NN cord-349011-kxhpdvri 27 8 was be VBD cord-349011-kxhpdvri 27 9 delivered deliver VBN cord-349011-kxhpdvri 27 10 by by IN cord-349011-kxhpdvri 27 11 Dr. Dr. NNP cord-349011-kxhpdvri 27 12 Sylvain Sylvain NNP cord-349011-kxhpdvri 27 13 Moineau Moineau NNP cord-349011-kxhpdvri 27 14 ( ( -LRB- cord-349011-kxhpdvri 27 15 Université Université NNP cord-349011-kxhpdvri 27 16 Laval Laval NNP cord-349011-kxhpdvri 27 17 ) ) -RRB- cord-349011-kxhpdvri 27 18 who who WP cord-349011-kxhpdvri 27 19 transitioned transition VBD cord-349011-kxhpdvri 27 20 from from IN cord-349011-kxhpdvri 27 21 human human JJ cord-349011-kxhpdvri 27 22 hosts host NNS cord-349011-kxhpdvri 27 23 to to IN cord-349011-kxhpdvri 27 24 bacterial bacterial JJ cord-349011-kxhpdvri 27 25 hosts host NNS cord-349011-kxhpdvri 27 26 in in IN cord-349011-kxhpdvri 27 27 a a DT cord-349011-kxhpdvri 27 28 fascinating fascinating JJ cord-349011-kxhpdvri 27 29 talk talk NN cord-349011-kxhpdvri 27 30 about about IN cord-349011-kxhpdvri 27 31 CRISPR CRISPR NNP cord-349011-kxhpdvri 27 32 - - HYPH cord-349011-kxhpdvri 27 33 Cas Cas NNP cord-349011-kxhpdvri 27 34 antiviral antiviral JJ cord-349011-kxhpdvri 27 35 systems system NNS cord-349011-kxhpdvri 27 36 . . . cord-349011-kxhpdvri 28 1 Bacteria Bacteria NNS cord-349011-kxhpdvri 28 2 thrive thrive VBP cord-349011-kxhpdvri 28 3 in in IN cord-349011-kxhpdvri 28 4 virus virus NN cord-349011-kxhpdvri 28 5 - - HYPH cord-349011-kxhpdvri 28 6 rich rich JJ cord-349011-kxhpdvri 28 7 ecosystems ecosystem NNS cord-349011-kxhpdvri 28 8 by by IN cord-349011-kxhpdvri 28 9 using use VBG cord-349011-kxhpdvri 28 10 a a DT cord-349011-kxhpdvri 28 11 combination combination NN cord-349011-kxhpdvri 28 12 of of IN cord-349011-kxhpdvri 28 13 antiviral antiviral JJ cord-349011-kxhpdvri 28 14 defenses defense NNS cord-349011-kxhpdvri 28 15 including include VBG cord-349011-kxhpdvri 28 16 restriction restriction NN cord-349011-kxhpdvri 28 17 endonucleases endonuclease NNS cord-349011-kxhpdvri 28 18 and and CC cord-349011-kxhpdvri 28 19 CRISPR CRISPR NNP cord-349011-kxhpdvri 28 20 - - HYPH cord-349011-kxhpdvri 28 21 Cas Cas NNP cord-349011-kxhpdvri 28 22 enzymes enzyme NNS cord-349011-kxhpdvri 28 23 that that WDT cord-349011-kxhpdvri 28 24 effectively effectively RB cord-349011-kxhpdvri 28 25 act act VBP cord-349011-kxhpdvri 28 26 as as IN cord-349011-kxhpdvri 28 27 bacterial bacterial JJ cord-349011-kxhpdvri 28 28 intrinsic intrinsic JJ cord-349011-kxhpdvri 28 29 and and CC cord-349011-kxhpdvri 28 30 adaptive adaptive JJ cord-349011-kxhpdvri 28 31 immune immune JJ cord-349011-kxhpdvri 28 32 systems system NNS cord-349011-kxhpdvri 28 33 , , , cord-349011-kxhpdvri 28 34 respectively respectively RB cord-349011-kxhpdvri 28 35 . . . cord-349011-kxhpdvri 29 1 Dr. Dr. NNP cord-349011-kxhpdvri 29 2 Moineau Moineau NNP cord-349011-kxhpdvri 29 3 focused focus VBD cord-349011-kxhpdvri 29 4 on on IN cord-349011-kxhpdvri 29 5 bacterial bacterial JJ cord-349011-kxhpdvri 29 6 CRISPR CRISPR NNP cord-349011-kxhpdvri 29 7 - - HYPH cord-349011-kxhpdvri 29 8 Cas Cas NNP cord-349011-kxhpdvri 29 9 type type NN cord-349011-kxhpdvri 29 10 II II NNP cord-349011-kxhpdvri 29 11 systems system NNS cord-349011-kxhpdvri 29 12 that that WDT cord-349011-kxhpdvri 29 13 function function VBP cord-349011-kxhpdvri 29 14 by by IN cord-349011-kxhpdvri 29 15 archiving archive VBG cord-349011-kxhpdvri 29 16 short short JJ cord-349011-kxhpdvri 29 17 DNA dna NN cord-349011-kxhpdvri 29 18 " " `` cord-349011-kxhpdvri 29 19 spacers spacer NNS cord-349011-kxhpdvri 29 20 " " '' cord-349011-kxhpdvri 29 21 derived derive VBN cord-349011-kxhpdvri 29 22 from from IN cord-349011-kxhpdvri 29 23 invading invade VBG cord-349011-kxhpdvri 29 24 phage phage NN cord-349011-kxhpdvri 29 25 genomes genome NNS cord-349011-kxhpdvri 29 26 into into IN cord-349011-kxhpdvri 29 27 a a DT cord-349011-kxhpdvri 29 28 CRISPR CRISPR NNP cord-349011-kxhpdvri 29 29 array array NN cord-349011-kxhpdvri 29 30 in in IN cord-349011-kxhpdvri 29 31 their -PRON- PRP$ cord-349011-kxhpdvri 29 32 genome genome NN cord-349011-kxhpdvri 29 33 , , , cord-349011-kxhpdvri 29 34 providing provide VBG cord-349011-kxhpdvri 29 35 a a DT cord-349011-kxhpdvri 29 36 chronological chronological JJ cord-349011-kxhpdvri 29 37 record record NN cord-349011-kxhpdvri 29 38 of of IN cord-349011-kxhpdvri 29 39 past past JJ cord-349011-kxhpdvri 29 40 infections infection NNS cord-349011-kxhpdvri 29 41 . . . cord-349011-kxhpdvri 30 1 The the DT cord-349011-kxhpdvri 30 2 CRISPR CRISPR NNP cord-349011-kxhpdvri 30 3 array array NN cord-349011-kxhpdvri 30 4 is be VBZ cord-349011-kxhpdvri 30 5 then then RB cord-349011-kxhpdvri 30 6 transcribed transcribe VBN cord-349011-kxhpdvri 30 7 into into IN cord-349011-kxhpdvri 30 8 a a DT cord-349011-kxhpdvri 30 9 " " `` cord-349011-kxhpdvri 30 10 guide guide NN cord-349011-kxhpdvri 30 11 " " '' cord-349011-kxhpdvri 30 12 RNA RNA NNP cord-349011-kxhpdvri 30 13 that that IN cord-349011-kxhpdvri 30 14 associates associate NNS cord-349011-kxhpdvri 30 15 with with IN cord-349011-kxhpdvri 30 16 a a DT cord-349011-kxhpdvri 30 17 Cas Cas NNP cord-349011-kxhpdvri 30 18 endonuclease endonuclease NN cord-349011-kxhpdvri 30 19 and and CC cord-349011-kxhpdvri 30 20 allows allow VBZ cord-349011-kxhpdvri 30 21 it -PRON- PRP cord-349011-kxhpdvri 30 22 to to TO cord-349011-kxhpdvri 30 23 cleave cleave VB cord-349011-kxhpdvri 30 24 incoming incoming JJ cord-349011-kxhpdvri 30 25 foreign foreign JJ cord-349011-kxhpdvri 30 26 viral viral JJ cord-349011-kxhpdvri 30 27 DNA dna NN cord-349011-kxhpdvri 30 28 . . . cord-349011-kxhpdvri 31 1 Bacterial bacterial JJ cord-349011-kxhpdvri 31 2 viruses virus NNS cord-349011-kxhpdvri 31 3 , , , cord-349011-kxhpdvri 31 4 known know VBN cord-349011-kxhpdvri 31 5 as as IN cord-349011-kxhpdvri 31 6 phage phage NN cord-349011-kxhpdvri 31 7 , , , cord-349011-kxhpdvri 31 8 are be VBP cord-349011-kxhpdvri 31 9 not not RB cord-349011-kxhpdvri 31 10 defenseless defenseless JJ cord-349011-kxhpdvri 31 11 ; ; : cord-349011-kxhpdvri 31 12 they -PRON- PRP cord-349011-kxhpdvri 31 13 can can MD cord-349011-kxhpdvri 31 14 bypass bypass VB cord-349011-kxhpdvri 31 15 CRISPR CRISPR NNP cord-349011-kxhpdvri 31 16 - - HYPH cord-349011-kxhpdvri 31 17 Cas Cas NNP cord-349011-kxhpdvri 31 18 targeting target VBG cord-349011-kxhpdvri 31 19 by by IN cord-349011-kxhpdvri 31 20 mutation mutation NN cord-349011-kxhpdvri 31 21 or or CC cord-349011-kxhpdvri 31 22 deletion deletion NN cord-349011-kxhpdvri 31 23 of of IN cord-349011-kxhpdvri 31 24 the the DT cord-349011-kxhpdvri 31 25 CRISPR CRISPR NNP cord-349011-kxhpdvri 31 26 target target NN cord-349011-kxhpdvri 31 27 in in IN cord-349011-kxhpdvri 31 28 their -PRON- PRP$ cord-349011-kxhpdvri 31 29 genome genome NN cord-349011-kxhpdvri 31 30 , , , cord-349011-kxhpdvri 31 31 or or CC cord-349011-kxhpdvri 31 32 by by IN cord-349011-kxhpdvri 31 33 production production NN cord-349011-kxhpdvri 31 34 of of IN cord-349011-kxhpdvri 31 35 anti anti JJ cord-349011-kxhpdvri 31 36 - - JJ cord-349011-kxhpdvri 31 37 CRISPR crispr JJ cord-349011-kxhpdvri 31 38 proteins protein NNS cord-349011-kxhpdvri 31 39 that that WDT cord-349011-kxhpdvri 31 40 subvert subvert VBP cord-349011-kxhpdvri 31 41 the the DT cord-349011-kxhpdvri 31 42 CRISPR CRISPR NNP cord-349011-kxhpdvri 31 43 - - HYPH cord-349011-kxhpdvri 31 44 Cas Cas NNP cord-349011-kxhpdvri 31 45 machinery machinery NN cord-349011-kxhpdvri 31 46 . . . cord-349011-kxhpdvri 32 1 Dr. Dr. NNP cord-349011-kxhpdvri 32 2 Moineau Moineau NNP cord-349011-kxhpdvri 32 3 discussed discuss VBD cord-349011-kxhpdvri 32 4 current current JJ cord-349011-kxhpdvri 32 5 and and CC cord-349011-kxhpdvri 32 6 potential potential JJ cord-349011-kxhpdvri 32 7 applications application NNS cord-349011-kxhpdvri 32 8 of of IN cord-349011-kxhpdvri 32 9 CRISPR CRISPR NNP cord-349011-kxhpdvri 32 10 technology technology NN cord-349011-kxhpdvri 32 11 and and CC cord-349011-kxhpdvri 32 12 introduced introduce VBD cord-349011-kxhpdvri 32 13 the the DT cord-349011-kxhpdvri 32 14 audience audience NN cord-349011-kxhpdvri 32 15 to to IN cord-349011-kxhpdvri 32 16 a a DT cord-349011-kxhpdvri 32 17 wide wide JJ cord-349011-kxhpdvri 32 18 variety variety NN cord-349011-kxhpdvri 32 19 of of IN cord-349011-kxhpdvri 32 20 newly newly RB cord-349011-kxhpdvri 32 21 discovered discover VBN cord-349011-kxhpdvri 32 22 anti anti JJ cord-349011-kxhpdvri 32 23 - - JJ cord-349011-kxhpdvri 32 24 CRISPR crispr JJ cord-349011-kxhpdvri 32 25 proteins protein NNS cord-349011-kxhpdvri 32 26 that that WDT cord-349011-kxhpdvri 32 27 will will MD cord-349011-kxhpdvri 32 28 undoubtedly undoubtedly RB cord-349011-kxhpdvri 32 29 be be VB cord-349011-kxhpdvri 32 30 the the DT cord-349011-kxhpdvri 32 31 subject subject NN cord-349011-kxhpdvri 32 32 of of IN cord-349011-kxhpdvri 32 33 intense intense JJ cord-349011-kxhpdvri 32 34 investigation investigation NN cord-349011-kxhpdvri 32 35 for for IN cord-349011-kxhpdvri 32 36 years year NNS cord-349011-kxhpdvri 32 37 to to TO cord-349011-kxhpdvri 32 38 come come VB cord-349011-kxhpdvri 32 39 [ [ -LRB- cord-349011-kxhpdvri 32 40 2 2 CD cord-349011-kxhpdvri 32 41 , , , cord-349011-kxhpdvri 32 42 3 3 CD cord-349011-kxhpdvri 32 43 ] ] -RRB- cord-349011-kxhpdvri 32 44 . . . cord-349011-kxhpdvri 33 1 He -PRON- PRP cord-349011-kxhpdvri 33 2 also also RB cord-349011-kxhpdvri 33 3 described describe VBD cord-349011-kxhpdvri 33 4 his -PRON- PRP$ cord-349011-kxhpdvri 33 5 efforts effort NNS cord-349011-kxhpdvri 33 6 to to TO cord-349011-kxhpdvri 33 7 bring bring VB cord-349011-kxhpdvri 33 8 CRISPR CRISPR NNP cord-349011-kxhpdvri 33 9 - - HYPH cord-349011-kxhpdvri 33 10 Cas Cas NNP cord-349011-kxhpdvri 33 11 technology technology NN cord-349011-kxhpdvri 33 12 to to IN cord-349011-kxhpdvri 33 13 the the DT cord-349011-kxhpdvri 33 14 undergraduate undergraduate JJ cord-349011-kxhpdvri 33 15 laboratory laboratory NN cord-349011-kxhpdvri 33 16 curriculum curriculum NN cord-349011-kxhpdvri 33 17 at at IN cord-349011-kxhpdvri 33 18 Université Université NNP cord-349011-kxhpdvri 33 19 Laval Laval NNP cord-349011-kxhpdvri 33 20 [ [ -LRB- cord-349011-kxhpdvri 33 21 4 4 CD cord-349011-kxhpdvri 33 22 ] ] -RRB- cord-349011-kxhpdvri 33 23 . . . cord-349011-kxhpdvri 34 1 The the DT cord-349011-kxhpdvri 34 2 second second JJ cord-349011-kxhpdvri 34 3 day day NN cord-349011-kxhpdvri 34 4 of of IN cord-349011-kxhpdvri 34 5 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 34 6 started start VBD cord-349011-kxhpdvri 34 7 early early RB cord-349011-kxhpdvri 34 8 for for IN cord-349011-kxhpdvri 34 9 some some DT cord-349011-kxhpdvri 34 10 , , , cord-349011-kxhpdvri 34 11 with with IN cord-349011-kxhpdvri 34 12 a a DT cord-349011-kxhpdvri 34 13 student student NN cord-349011-kxhpdvri 34 14 - - HYPH cord-349011-kxhpdvri 34 15 led lead VBN cord-349011-kxhpdvri 34 16 Fun Fun NNP cord-349011-kxhpdvri 34 17 Run Run NNP cord-349011-kxhpdvri 34 18 through through IN cord-349011-kxhpdvri 34 19 South South NNP cord-349011-kxhpdvri 34 20 End End NNP cord-349011-kxhpdvri 34 21 Halifax Halifax NNP cord-349011-kxhpdvri 34 22 and and CC cord-349011-kxhpdvri 34 23 Point Point NNP cord-349011-kxhpdvri 34 24 Pleasant Pleasant NNP cord-349011-kxhpdvri 34 25 Park Park NNP cord-349011-kxhpdvri 34 26 . . . cord-349011-kxhpdvri 35 1 When when WRB cord-349011-kxhpdvri 35 2 Fun Fun NNP cord-349011-kxhpdvri 35 3 Run Run NNP cord-349011-kxhpdvri 35 4 survivors survivor NNS cord-349011-kxhpdvri 35 5 arrived arrive VBD cord-349011-kxhpdvri 35 6 at at IN cord-349011-kxhpdvri 35 7 breakfast breakfast NN cord-349011-kxhpdvri 35 8 , , , cord-349011-kxhpdvri 35 9 they -PRON- PRP cord-349011-kxhpdvri 35 10 were be VBD cord-349011-kxhpdvri 35 11 greeted greet VBN cord-349011-kxhpdvri 35 12 by by IN cord-349011-kxhpdvri 35 13 volunteers volunteer NNS cord-349011-kxhpdvri 35 14 who who WP cord-349011-kxhpdvri 35 15 gave give VBD cord-349011-kxhpdvri 35 16 them -PRON- PRP cord-349011-kxhpdvri 35 17 seating seating NN cord-349011-kxhpdvri 35 18 assignments assignment NNS cord-349011-kxhpdvri 35 19 that that WDT cord-349011-kxhpdvri 35 20 maximized maximize VBD cord-349011-kxhpdvri 35 21 potential potential JJ cord-349011-kxhpdvri 35 22 interactions interaction NNS cord-349011-kxhpdvri 35 23 between between IN cord-349011-kxhpdvri 35 24 PIs pi NNS cord-349011-kxhpdvri 35 25 and and CC cord-349011-kxhpdvri 35 26 students student NNS cord-349011-kxhpdvri 35 27 . . . cord-349011-kxhpdvri 36 1 Following follow VBG cord-349011-kxhpdvri 36 2 this this DT cord-349011-kxhpdvri 36 3 , , , cord-349011-kxhpdvri 36 4 the the DT cord-349011-kxhpdvri 36 5 first first JJ cord-349011-kxhpdvri 36 6 scientific scientific JJ cord-349011-kxhpdvri 36 7 session session NN cord-349011-kxhpdvri 36 8 of of IN cord-349011-kxhpdvri 36 9 the the DT cord-349011-kxhpdvri 36 10 day day NN cord-349011-kxhpdvri 36 11 commenced commence VBD cord-349011-kxhpdvri 36 12 , , , cord-349011-kxhpdvri 36 13 chaired chair VBN cord-349011-kxhpdvri 36 14 by by IN cord-349011-kxhpdvri 36 15 Dr. Dr. NNP cord-349011-kxhpdvri 36 16 Hugo Hugo NNP cord-349011-kxhpdvri 36 17 Soudeyns Soudeyns NNP cord-349011-kxhpdvri 36 18 ( ( -LRB- cord-349011-kxhpdvri 36 19 Université Université NNP cord-349011-kxhpdvri 36 20 de de FW cord-349011-kxhpdvri 36 21 Montréal Montréal NNP cord-349011-kxhpdvri 36 22 ) ) -RRB- cord-349011-kxhpdvri 36 23 , , , cord-349011-kxhpdvri 36 24 on on IN cord-349011-kxhpdvri 36 25 " " `` cord-349011-kxhpdvri 36 26 Emerging Emerging NNP cord-349011-kxhpdvri 36 27 Viruses Viruses NNPS cord-349011-kxhpdvri 36 28 " " '' cord-349011-kxhpdvri 36 29 . . . cord-349011-kxhpdvri 37 1 To to TO cord-349011-kxhpdvri 37 2 lead lead VB cord-349011-kxhpdvri 37 3 off off RP cord-349011-kxhpdvri 37 4 , , , cord-349011-kxhpdvri 37 5 Dr. Dr. NNP cord-349011-kxhpdvri 37 6 Vikram Vikram NNP cord-349011-kxhpdvri 37 7 Misra Misra NNP cord-349011-kxhpdvri 37 8 ( ( -LRB- cord-349011-kxhpdvri 37 9 University University NNP cord-349011-kxhpdvri 37 10 of of IN cord-349011-kxhpdvri 37 11 Saskatchewan Saskatchewan NNP cord-349011-kxhpdvri 37 12 , , , cord-349011-kxhpdvri 37 13 Saskatoon Saskatoon NNP cord-349011-kxhpdvri 37 14 , , , cord-349011-kxhpdvri 37 15 SK SK NNP cord-349011-kxhpdvri 37 16 ) ) -RRB- cord-349011-kxhpdvri 37 17 presented present VBD cord-349011-kxhpdvri 37 18 his -PRON- PRP$ cord-349011-kxhpdvri 37 19 studies study NNS cord-349011-kxhpdvri 37 20 of of IN cord-349011-kxhpdvri 37 21 bat bat NN cord-349011-kxhpdvri 37 22 viruses virus NNS cord-349011-kxhpdvri 37 23 . . . cord-349011-kxhpdvri 38 1 In in IN cord-349011-kxhpdvri 38 2 recent recent JJ cord-349011-kxhpdvri 38 3 years year NNS cord-349011-kxhpdvri 38 4 several several JJ cord-349011-kxhpdvri 38 5 viruses virus NNS cord-349011-kxhpdvri 38 6 that that WDT cord-349011-kxhpdvri 38 7 appear appear VBP cord-349011-kxhpdvri 38 8 to to TO cord-349011-kxhpdvri 38 9 cause cause VB cord-349011-kxhpdvri 38 10 no no DT cord-349011-kxhpdvri 38 11 overt overt JJ cord-349011-kxhpdvri 38 12 disease disease NN cord-349011-kxhpdvri 38 13 in in IN cord-349011-kxhpdvri 38 14 their -PRON- PRP$ cord-349011-kxhpdvri 38 15 natural natural JJ cord-349011-kxhpdvri 38 16 bat bat NN cord-349011-kxhpdvri 38 17 hosts host NNS cord-349011-kxhpdvri 38 18 have have VBP cord-349011-kxhpdvri 38 19 been be VBN cord-349011-kxhpdvri 38 20 transmitted transmit VBN cord-349011-kxhpdvri 38 21 to to IN cord-349011-kxhpdvri 38 22 new new JJ cord-349011-kxhpdvri 38 23 mammalian mammalian JJ cord-349011-kxhpdvri 38 24 hosts host NNS cord-349011-kxhpdvri 38 25 , , , cord-349011-kxhpdvri 38 26 causing cause VBG cord-349011-kxhpdvri 38 27 serious serious JJ cord-349011-kxhpdvri 38 28 and and CC cord-349011-kxhpdvri 38 29 sometimes sometimes RB cord-349011-kxhpdvri 38 30 fatal fatal JJ cord-349011-kxhpdvri 38 31 disease disease NN cord-349011-kxhpdvri 38 32 . . . cord-349011-kxhpdvri 39 1 Dr. Dr. NNP cord-349011-kxhpdvri 39 2 Misra Misra NNP cord-349011-kxhpdvri 39 3 's 's POS cord-349011-kxhpdvri 39 4 research research NN cord-349011-kxhpdvri 39 5 program program NN cord-349011-kxhpdvri 39 6 is be VBZ cord-349011-kxhpdvri 39 7 focused focus VBN cord-349011-kxhpdvri 39 8 on on IN cord-349011-kxhpdvri 39 9 examining examine VBG cord-349011-kxhpdvri 39 10 the the DT cord-349011-kxhpdvri 39 11 apparently apparently RB cord-349011-kxhpdvri 39 12 benign benign JJ cord-349011-kxhpdvri 39 13 relationship relationship NN cord-349011-kxhpdvri 39 14 between between IN cord-349011-kxhpdvri 39 15 these these DT cord-349011-kxhpdvri 39 16 viruses virus NNS cord-349011-kxhpdvri 39 17 and and CC cord-349011-kxhpdvri 39 18 their -PRON- PRP$ cord-349011-kxhpdvri 39 19 natural natural JJ cord-349011-kxhpdvri 39 20 bat bat NN cord-349011-kxhpdvri 39 21 hosts host NNS cord-349011-kxhpdvri 39 22 , , , cord-349011-kxhpdvri 39 23 as as RB cord-349011-kxhpdvri 39 24 well well RB cord-349011-kxhpdvri 39 25 as as IN cord-349011-kxhpdvri 39 26 factors factor NNS cord-349011-kxhpdvri 39 27 that that WDT cord-349011-kxhpdvri 39 28 upset upset VBD cord-349011-kxhpdvri 39 29 this this DT cord-349011-kxhpdvri 39 30 relationship relationship NN cord-349011-kxhpdvri 39 31 leading lead VBG cord-349011-kxhpdvri 39 32 to to IN cord-349011-kxhpdvri 39 33 increased increase VBN cord-349011-kxhpdvri 39 34 viral viral JJ cord-349011-kxhpdvri 39 35 replication replication NN cord-349011-kxhpdvri 39 36 and and CC cord-349011-kxhpdvri 39 37 transmission transmission NN cord-349011-kxhpdvri 39 38 to to IN cord-349011-kxhpdvri 39 39 new new JJ cord-349011-kxhpdvri 39 40 mammalian mammalian JJ cord-349011-kxhpdvri 39 41 hosts host NNS cord-349011-kxhpdvri 39 42 ( ( -LRB- cord-349011-kxhpdvri 39 43 recently recently RB cord-349011-kxhpdvri 39 44 reviewed review VBN cord-349011-kxhpdvri 39 45 in in IN cord-349011-kxhpdvri 39 46 [ [ -LRB- cord-349011-kxhpdvri 39 47 5 5 CD cord-349011-kxhpdvri 39 48 ] ] -RRB- cord-349011-kxhpdvri 39 49 ) ) -RRB- cord-349011-kxhpdvri 39 50 . . . cord-349011-kxhpdvri 40 1 His -PRON- PRP$ cord-349011-kxhpdvri 40 2 team team NN cord-349011-kxhpdvri 40 3 , , , cord-349011-kxhpdvri 40 4 in in IN cord-349011-kxhpdvri 40 5 a a DT cord-349011-kxhpdvri 40 6 comparison comparison NN cord-349011-kxhpdvri 40 7 of of IN cord-349011-kxhpdvri 40 8 bat bat NN cord-349011-kxhpdvri 40 9 and and CC cord-349011-kxhpdvri 40 10 human human JJ cord-349011-kxhpdvri 40 11 host host NN cord-349011-kxhpdvri 40 12 responses response NNS cord-349011-kxhpdvri 40 13 to to IN cord-349011-kxhpdvri 40 14 viral viral JJ cord-349011-kxhpdvri 40 15 infection infection NN cord-349011-kxhpdvri 40 16 , , , cord-349011-kxhpdvri 40 17 demonstrated demonstrate VBD cord-349011-kxhpdvri 40 18 that that IN cord-349011-kxhpdvri 40 19 while while IN cord-349011-kxhpdvri 40 20 both both DT cord-349011-kxhpdvri 40 21 animals animal NNS cord-349011-kxhpdvri 40 22 mount mount VBP cord-349011-kxhpdvri 40 23 antiviral antiviral JJ cord-349011-kxhpdvri 40 24 responses response NNS cord-349011-kxhpdvri 40 25 , , , cord-349011-kxhpdvri 40 26 inflammatory inflammatory JJ cord-349011-kxhpdvri 40 27 responses response NNS cord-349011-kxhpdvri 40 28 are be VBP cord-349011-kxhpdvri 40 29 diminished diminish VBN cord-349011-kxhpdvri 40 30 in in IN cord-349011-kxhpdvri 40 31 bat bat NN cord-349011-kxhpdvri 40 32 cells cell NNS cord-349011-kxhpdvri 40 33 [ [ -LRB- cord-349011-kxhpdvri 40 34 6 6 CD cord-349011-kxhpdvri 40 35 ] ] -RRB- cord-349011-kxhpdvri 40 36 potentially potentially RB cord-349011-kxhpdvri 40 37 decreasing decrease VBG cord-349011-kxhpdvri 40 38 viral viral JJ cord-349011-kxhpdvri 40 39 pathology pathology NN cord-349011-kxhpdvri 40 40 . . . cord-349011-kxhpdvri 41 1 Moreover moreover RB cord-349011-kxhpdvri 41 2 , , , cord-349011-kxhpdvri 41 3 antiviral antiviral JJ cord-349011-kxhpdvri 41 4 responses response NNS cord-349011-kxhpdvri 41 5 in in IN cord-349011-kxhpdvri 41 6 bat bat NN cord-349011-kxhpdvri 41 7 cells cell NNS cord-349011-kxhpdvri 41 8 were be VBD cord-349011-kxhpdvri 41 9 resistant resistant JJ cord-349011-kxhpdvri 41 10 to to IN cord-349011-kxhpdvri 41 11 viral viral JJ cord-349011-kxhpdvri 41 12 subversion subversion NN cord-349011-kxhpdvri 41 13 mechanisms mechanism NNS cord-349011-kxhpdvri 41 14 that that WDT cord-349011-kxhpdvri 41 15 normally normally RB cord-349011-kxhpdvri 41 16 operate operate VBP cord-349011-kxhpdvri 41 17 in in IN cord-349011-kxhpdvri 41 18 human human JJ cord-349011-kxhpdvri 41 19 host host NN cord-349011-kxhpdvri 41 20 cells cell NNS cord-349011-kxhpdvri 41 21 . . . cord-349011-kxhpdvri 42 1 The the DT cord-349011-kxhpdvri 42 2 Misra Misra NNP cord-349011-kxhpdvri 42 3 laboratory laboratory NN cord-349011-kxhpdvri 42 4 has have VBZ cord-349011-kxhpdvri 42 5 identified identify VBN cord-349011-kxhpdvri 42 6 a a DT cord-349011-kxhpdvri 42 7 new new JJ cord-349011-kxhpdvri 42 8 bat bat NN cord-349011-kxhpdvri 42 9 coronavirus coronavirus NN cord-349011-kxhpdvri 42 10 [ [ -LRB- cord-349011-kxhpdvri 42 11 7 7 CD cord-349011-kxhpdvri 42 12 ] ] -RRB- cord-349011-kxhpdvri 42 13 and and CC cord-349011-kxhpdvri 42 14 a a DT cord-349011-kxhpdvri 42 15 new new JJ cord-349011-kxhpdvri 42 16 bat bat NN cord-349011-kxhpdvri 42 17 herpesvirus herpesvirus NN cord-349011-kxhpdvri 42 18 [ [ -LRB- cord-349011-kxhpdvri 42 19 8 8 CD cord-349011-kxhpdvri 42 20 ] ] -RRB- cord-349011-kxhpdvri 42 21 that that IN cord-349011-kxhpdvri 42 22 persistently persistently RB cord-349011-kxhpdvri 42 23 infect infect VBP cord-349011-kxhpdvri 42 24 two two CD cord-349011-kxhpdvri 42 25 Canadian canadian JJ cord-349011-kxhpdvri 42 26 bat bat NN cord-349011-kxhpdvri 42 27 species specie NNS cord-349011-kxhpdvri 42 28 with with IN cord-349011-kxhpdvri 42 29 no no DT cord-349011-kxhpdvri 42 30 overt overt JJ cord-349011-kxhpdvri 42 31 signs sign NNS cord-349011-kxhpdvri 42 32 of of IN cord-349011-kxhpdvri 42 33 disease disease NN cord-349011-kxhpdvri 42 34 . . . cord-349011-kxhpdvri 43 1 Both both DT cord-349011-kxhpdvri 43 2 viruses virus NNS cord-349011-kxhpdvri 43 3 infect infect VBP cord-349011-kxhpdvri 43 4 many many JJ cord-349011-kxhpdvri 43 5 , , , cord-349011-kxhpdvri 43 6 if if IN cord-349011-kxhpdvri 43 7 not not RB cord-349011-kxhpdvri 43 8 most most JJS cord-349011-kxhpdvri 43 9 , , , cord-349011-kxhpdvri 43 10 bats bat NNS cord-349011-kxhpdvri 43 11 in in IN cord-349011-kxhpdvri 43 12 long long JJ cord-349011-kxhpdvri 43 13 - - HYPH cord-349011-kxhpdvri 43 14 term term NN cord-349011-kxhpdvri 43 15 associations association NNS cord-349011-kxhpdvri 43 16 without without IN cord-349011-kxhpdvri 43 17 causing cause VBG cord-349011-kxhpdvri 43 18 overt overt JJ cord-349011-kxhpdvri 43 19 disease disease NN cord-349011-kxhpdvri 43 20 . . . cord-349011-kxhpdvri 44 1 The the DT cord-349011-kxhpdvri 44 2 stress stress NN cord-349011-kxhpdvri 44 3 of of IN cord-349011-kxhpdvri 44 4 white white JJ cord-349011-kxhpdvri 44 5 - - HYPH cord-349011-kxhpdvri 44 6 nose nose NN cord-349011-kxhpdvri 44 7 syndrome syndrome NN cord-349011-kxhpdvri 44 8 , , , cord-349011-kxhpdvri 44 9 a a DT cord-349011-kxhpdvri 44 10 fungal fungal JJ cord-349011-kxhpdvri 44 11 infection infection NN cord-349011-kxhpdvri 44 12 that that WDT cord-349011-kxhpdvri 44 13 has have VBZ cord-349011-kxhpdvri 44 14 decimated decimate VBN cord-349011-kxhpdvri 44 15 some some DT cord-349011-kxhpdvri 44 16 north north JJ cord-349011-kxhpdvri 44 17 American american JJ cord-349011-kxhpdvri 44 18 bat bat NN cord-349011-kxhpdvri 44 19 species specie NNS cord-349011-kxhpdvri 44 20 , , , cord-349011-kxhpdvri 44 21 leads lead VBZ cord-349011-kxhpdvri 44 22 to to IN cord-349011-kxhpdvri 44 23 a a DT cord-349011-kxhpdvri 44 24 dramatic dramatic JJ cord-349011-kxhpdvri 44 25 increase increase NN cord-349011-kxhpdvri 44 26 in in IN cord-349011-kxhpdvri 44 27 corona corona NN cord-349011-kxhpdvri 44 28 virus virus NN cord-349011-kxhpdvri 44 29 replication replication NN cord-349011-kxhpdvri 44 30 in in IN cord-349011-kxhpdvri 44 31 little little JJ cord-349011-kxhpdvri 44 32 brown brown JJ cord-349011-kxhpdvri 44 33 bats bat NNS cord-349011-kxhpdvri 44 34 , , , cord-349011-kxhpdvri 44 35 potentially potentially RB cord-349011-kxhpdvri 44 36 increasing increase VBG cord-349011-kxhpdvri 44 37 the the DT cord-349011-kxhpdvri 44 38 chances chance NNS cord-349011-kxhpdvri 44 39 of of IN cord-349011-kxhpdvri 44 40 transmission transmission NN cord-349011-kxhpdvri 44 41 to to IN cord-349011-kxhpdvri 44 42 other other JJ cord-349011-kxhpdvri 44 43 species specie NNS cord-349011-kxhpdvri 44 44 [ [ -LRB- cord-349011-kxhpdvri 44 45 9 9 CD cord-349011-kxhpdvri 44 46 ] ] -RRB- cord-349011-kxhpdvri 44 47 . . . cord-349011-kxhpdvri 45 1 Long long JJ cord-349011-kxhpdvri 45 2 - - HYPH cord-349011-kxhpdvri 45 3 term term NN cord-349011-kxhpdvri 45 4 viral viral JJ cord-349011-kxhpdvri 45 5 persistence persistence NN cord-349011-kxhpdvri 45 6 followed follow VBN cord-349011-kxhpdvri 45 7 by by IN cord-349011-kxhpdvri 45 8 stress stress NN cord-349011-kxhpdvri 45 9 - - HYPH cord-349011-kxhpdvri 45 10 induced induce VBN cord-349011-kxhpdvri 45 11 reactivation reactivation NN cord-349011-kxhpdvri 45 12 could could MD cord-349011-kxhpdvri 45 13 be be VB cord-349011-kxhpdvri 45 14 modeled model VBN cord-349011-kxhpdvri 45 15 in in IN cord-349011-kxhpdvri 45 16 tissue tissue NN cord-349011-kxhpdvri 45 17 - - HYPH cord-349011-kxhpdvri 45 18 culture culture NN cord-349011-kxhpdvri 45 19 where where WRB cord-349011-kxhpdvri 45 20 the the DT cord-349011-kxhpdvri 45 21 MERS MERS NNP cord-349011-kxhpdvri 45 22 - - HYPH cord-349011-kxhpdvri 45 23 coronavirus coronavirus NN cord-349011-kxhpdvri 45 24 persistently persistently RB cord-349011-kxhpdvri 45 25 infected infect VBN cord-349011-kxhpdvri 45 26 bat bat NN cord-349011-kxhpdvri 45 27 cells cell NNS cord-349011-kxhpdvri 45 28 and and CC cord-349011-kxhpdvri 45 29 the the DT cord-349011-kxhpdvri 45 30 suppression suppression NN cord-349011-kxhpdvri 45 31 of of IN cord-349011-kxhpdvri 45 32 innate innate JJ cord-349011-kxhpdvri 45 33 antiviral antiviral JJ cord-349011-kxhpdvri 45 34 responses response NNS cord-349011-kxhpdvri 45 35 led lead VBD cord-349011-kxhpdvri 45 36 to to IN cord-349011-kxhpdvri 45 37 increased increase VBN cord-349011-kxhpdvri 45 38 viral viral JJ cord-349011-kxhpdvri 45 39 replication replication NN cord-349011-kxhpdvri 45 40 [ [ -LRB- cord-349011-kxhpdvri 45 41 10 10 CD cord-349011-kxhpdvri 45 42 ] ] -RRB- cord-349011-kxhpdvri 45 43 . . . cord-349011-kxhpdvri 46 1 Studying study VBG cord-349011-kxhpdvri 46 2 interactions interaction NNS cord-349011-kxhpdvri 46 3 between between IN cord-349011-kxhpdvri 46 4 bat bat NN cord-349011-kxhpdvri 46 5 viruses virus NNS cord-349011-kxhpdvri 46 6 and and CC cord-349011-kxhpdvri 46 7 their -PRON- PRP$ cord-349011-kxhpdvri 46 8 natural natural JJ cord-349011-kxhpdvri 46 9 host host NN cord-349011-kxhpdvri 46 10 may may MD cord-349011-kxhpdvri 46 11 provide provide VB cord-349011-kxhpdvri 46 12 key key JJ cord-349011-kxhpdvri 46 13 information information NN cord-349011-kxhpdvri 46 14 to to TO cord-349011-kxhpdvri 46 15 prevent prevent VB cord-349011-kxhpdvri 46 16 future future JJ cord-349011-kxhpdvri 46 17 zoonoses zoonosis NNS cord-349011-kxhpdvri 46 18 . . . cord-349011-kxhpdvri 47 1 National National NNP cord-349011-kxhpdvri 47 2 Microbiology Microbiology NNP cord-349011-kxhpdvri 47 3 Laboratory Laboratory NNP cord-349011-kxhpdvri 47 4 ( ( -LRB- cord-349011-kxhpdvri 47 5 NML NML NNP cord-349011-kxhpdvri 47 6 ) ) -RRB- cord-349011-kxhpdvri 47 7 researchers researcher NNS cord-349011-kxhpdvri 47 8 developed develop VBD cord-349011-kxhpdvri 47 9 an an DT cord-349011-kxhpdvri 47 10 Ebola Ebola NNP cord-349011-kxhpdvri 47 11 vaccine vaccine NN cord-349011-kxhpdvri 47 12 by by IN cord-349011-kxhpdvri 47 13 pseudotyping pseudotype VBG cord-349011-kxhpdvri 47 14 vesicular vesicular JJ cord-349011-kxhpdvri 47 15 stomatitis stomatitis NN cord-349011-kxhpdvri 47 16 virus virus NN cord-349011-kxhpdvri 47 17 ( ( -LRB- cord-349011-kxhpdvri 47 18 VSV VSV NNP cord-349011-kxhpdvri 47 19 ) ) -RRB- cord-349011-kxhpdvri 47 20 with with IN cord-349011-kxhpdvri 47 21 Ebolavirus Ebolavirus NNP cord-349011-kxhpdvri 47 22 ( ( -LRB- cord-349011-kxhpdvri 47 23 EBOV EBOV NNP cord-349011-kxhpdvri 47 24 ) ) -RRB- cord-349011-kxhpdvri 47 25 glycoprotein glycoprotein NN cord-349011-kxhpdvri 47 26 precursor precursor NN cord-349011-kxhpdvri 47 27 ( ( -LRB- cord-349011-kxhpdvri 47 28 GPC GPC NNP cord-349011-kxhpdvri 47 29 ) ) -RRB- cord-349011-kxhpdvri 47 30 , , , cord-349011-kxhpdvri 47 31 yielding yield VBG cord-349011-kxhpdvri 47 32 the the DT cord-349011-kxhpdvri 47 33 rVSV rvsv JJ cord-349011-kxhpdvri 47 34 - - HYPH cord-349011-kxhpdvri 47 35 EBOV EBOV NNP cord-349011-kxhpdvri 47 36 - - HYPH cord-349011-kxhpdvri 47 37 GPC GPC NNP cord-349011-kxhpdvri 47 38 vaccine vaccine NN cord-349011-kxhpdvri 47 39 . . . cord-349011-kxhpdvri 48 1 This this DT cord-349011-kxhpdvri 48 2 vaccine vaccine NN cord-349011-kxhpdvri 48 3 was be VBD cord-349011-kxhpdvri 48 4 safe safe JJ cord-349011-kxhpdvri 48 5 and and CC cord-349011-kxhpdvri 48 6 efficacious efficacious JJ cord-349011-kxhpdvri 48 7 in in IN cord-349011-kxhpdvri 48 8 early early JJ cord-349011-kxhpdvri 48 9 clinical clinical JJ cord-349011-kxhpdvri 48 10 trials trial NNS cord-349011-kxhpdvri 48 11 and and CC cord-349011-kxhpdvri 48 12 was be VBD cord-349011-kxhpdvri 48 13 deployed deploy VBN cord-349011-kxhpdvri 48 14 in in IN cord-349011-kxhpdvri 48 15 West West NNP cord-349011-kxhpdvri 48 16 Africa Africa NNP cord-349011-kxhpdvri 48 17 in in IN cord-349011-kxhpdvri 48 18 2013 2013 CD cord-349011-kxhpdvri 48 19 as as IN cord-349011-kxhpdvri 48 20 an an DT cord-349011-kxhpdvri 48 21 emergency emergency NN cord-349011-kxhpdvri 48 22 measure measure NN cord-349011-kxhpdvri 48 23 to to TO cord-349011-kxhpdvri 48 24 quell quell VB cord-349011-kxhpdvri 48 25 an an DT cord-349011-kxhpdvri 48 26 Ebola Ebola NNP cord-349011-kxhpdvri 48 27 epidemic epidemic NN cord-349011-kxhpdvri 48 28 by by IN cord-349011-kxhpdvri 48 29 ring ring NN cord-349011-kxhpdvri 48 30 vaccination vaccination NN cord-349011-kxhpdvri 48 31 ( ( -LRB- cord-349011-kxhpdvri 48 32 effectively effectively RB cord-349011-kxhpdvri 48 33 , , , cord-349011-kxhpdvri 48 34 a a DT cord-349011-kxhpdvri 48 35 phase phase NN cord-349011-kxhpdvri 48 36 III iii CD cord-349011-kxhpdvri 48 37 clinical clinical JJ cord-349011-kxhpdvri 48 38 trial trial NN cord-349011-kxhpdvri 48 39 ) ) -RRB- cord-349011-kxhpdvri 48 40 [ [ -LRB- cord-349011-kxhpdvri 48 41 11 11 CD cord-349011-kxhpdvri 48 42 ] ] -RRB- cord-349011-kxhpdvri 48 43 . . . cord-349011-kxhpdvri 49 1 Lassa Lassa NNP cord-349011-kxhpdvri 49 2 virus virus NN cord-349011-kxhpdvri 49 3 is be VBZ cord-349011-kxhpdvri 49 4 an an DT cord-349011-kxhpdvri 49 5 arenavirus arenavirus NN cord-349011-kxhpdvri 49 6 endemic endemic JJ cord-349011-kxhpdvri 49 7 across across IN cord-349011-kxhpdvri 49 8 much much JJ cord-349011-kxhpdvri 49 9 of of IN cord-349011-kxhpdvri 49 10 West West NNP cord-349011-kxhpdvri 49 11 Africa Africa NNP cord-349011-kxhpdvri 49 12 . . . cord-349011-kxhpdvri 50 1 Rodents rodent NNS cord-349011-kxhpdvri 50 2 are be VBP cord-349011-kxhpdvri 50 3 the the DT cord-349011-kxhpdvri 50 4 natural natural JJ cord-349011-kxhpdvri 50 5 host host NN cord-349011-kxhpdvri 50 6 , , , cord-349011-kxhpdvri 50 7 and and CC cord-349011-kxhpdvri 50 8 zoonotic zoonotic JJ cord-349011-kxhpdvri 50 9 transmission transmission NN cord-349011-kxhpdvri 50 10 to to IN cord-349011-kxhpdvri 50 11 humans human NNS cord-349011-kxhpdvri 50 12 can can MD cord-349011-kxhpdvri 50 13 cause cause VB cord-349011-kxhpdvri 50 14 severe severe JJ cord-349011-kxhpdvri 50 15 hemorrhagic hemorrhagic JJ cord-349011-kxhpdvri 50 16 fevers fever NNS cord-349011-kxhpdvri 50 17 in in IN cord-349011-kxhpdvri 50 18 20 20 CD cord-349011-kxhpdvri 50 19 % % NN cord-349011-kxhpdvri 50 20 of of IN cord-349011-kxhpdvri 50 21 infected infected JJ cord-349011-kxhpdvri 50 22 individuals individual NNS cord-349011-kxhpdvri 50 23 . . . cord-349011-kxhpdvri 51 1 No no DT cord-349011-kxhpdvri 51 2 Lassa Lassa NNP cord-349011-kxhpdvri 51 3 virus virus NN cord-349011-kxhpdvri 51 4 vaccine vaccine NN cord-349011-kxhpdvri 51 5 is be VBZ cord-349011-kxhpdvri 51 6 currently currently RB cord-349011-kxhpdvri 51 7 available available JJ cord-349011-kxhpdvri 51 8 because because IN cord-349011-kxhpdvri 51 9 even even RB cord-349011-kxhpdvri 51 10 though though IN cord-349011-kxhpdvri 51 11 many many JJ cord-349011-kxhpdvri 51 12 candidates candidate NNS cord-349011-kxhpdvri 51 13 have have VBP cord-349011-kxhpdvri 51 14 performed perform VBN cord-349011-kxhpdvri 51 15 well well RB cord-349011-kxhpdvri 51 16 in in IN cord-349011-kxhpdvri 51 17 clinical clinical JJ cord-349011-kxhpdvri 51 18 trials trial NNS cord-349011-kxhpdvri 51 19 , , , cord-349011-kxhpdvri 51 20 none none NN cord-349011-kxhpdvri 51 21 have have VBP cord-349011-kxhpdvri 51 22 yet yet RB cord-349011-kxhpdvri 51 23 shown show VBN cord-349011-kxhpdvri 51 24 efficacy efficacy NN cord-349011-kxhpdvri 51 25 and and CC cord-349011-kxhpdvri 51 26 safety safety NN cord-349011-kxhpdvri 51 27 in in IN cord-349011-kxhpdvri 51 28 humans human NNS cord-349011-kxhpdvri 51 29 . . . cord-349011-kxhpdvri 52 1 NML NML NNP cord-349011-kxhpdvri 52 2 researchers researcher NNS cord-349011-kxhpdvri 52 3 developed develop VBD cord-349011-kxhpdvri 52 4 a a DT cord-349011-kxhpdvri 52 5 Lassa Lassa NNP cord-349011-kxhpdvri 52 6 fever fever NN cord-349011-kxhpdvri 52 7 vaccine vaccine NN cord-349011-kxhpdvri 52 8 using use VBG cord-349011-kxhpdvri 52 9 the the DT cord-349011-kxhpdvri 52 10 same same JJ cord-349011-kxhpdvri 52 11 VSV VSV NNP cord-349011-kxhpdvri 52 12 platform platform NN cord-349011-kxhpdvri 52 13 previously previously RB cord-349011-kxhpdvri 52 14 used use VBD cord-349011-kxhpdvri 52 15 to to TO cord-349011-kxhpdvri 52 16 create create VB cord-349011-kxhpdvri 52 17 the the DT cord-349011-kxhpdvri 52 18 successful successful JJ cord-349011-kxhpdvri 52 19 Ebola Ebola NNP cord-349011-kxhpdvri 52 20 vaccine vaccine NN cord-349011-kxhpdvri 52 21 by by IN cord-349011-kxhpdvri 52 22 inserting insert VBG cord-349011-kxhpdvri 52 23 Lassa Lassa NNP cord-349011-kxhpdvri 52 24 virus virus NN cord-349011-kxhpdvri 52 25 GPC GPC NNP cord-349011-kxhpdvri 52 26 gene gene NN cord-349011-kxhpdvri 52 27 into into IN cord-349011-kxhpdvri 52 28 the the DT cord-349011-kxhpdvri 52 29 VSV VSV NNP cord-349011-kxhpdvri 52 30 platform platform NN cord-349011-kxhpdvri 52 31 [ [ -LRB- cord-349011-kxhpdvri 52 32 12 12 CD cord-349011-kxhpdvri 52 33 ] ] -RRB- cord-349011-kxhpdvri 52 34 . . . cord-349011-kxhpdvri 53 1 Dr. Dr. NNP cord-349011-kxhpdvri 53 2 Michael Michael NNP cord-349011-kxhpdvri 53 3 Drebot Drebot NNP cord-349011-kxhpdvri 53 4 from from IN cord-349011-kxhpdvri 53 5 the the DT cord-349011-kxhpdvri 53 6 Zoonotic Zoonotic NNP cord-349011-kxhpdvri 53 7 Diseases Diseases NNPS cord-349011-kxhpdvri 53 8 and and CC cord-349011-kxhpdvri 53 9 Special Special NNP cord-349011-kxhpdvri 53 10 Pathogens Pathogens NNPS cord-349011-kxhpdvri 53 11 Program Program NNP cord-349011-kxhpdvri 53 12 at at IN cord-349011-kxhpdvri 53 13 the the DT cord-349011-kxhpdvri 53 14 NML NML NNP cord-349011-kxhpdvri 53 15 summarized summarize VBD cord-349011-kxhpdvri 53 16 the the DT cord-349011-kxhpdvri 53 17 pre pre JJ cord-349011-kxhpdvri 53 18 - - JJ cord-349011-kxhpdvri 53 19 clinical clinical JJ cord-349011-kxhpdvri 53 20 studies study NNS cord-349011-kxhpdvri 53 21 conducted conduct VBN cord-349011-kxhpdvri 53 22 to to IN cord-349011-kxhpdvri 53 23 date date NN cord-349011-kxhpdvri 53 24 on on IN cord-349011-kxhpdvri 53 25 the the DT cord-349011-kxhpdvri 53 26 " " `` cord-349011-kxhpdvri 53 27 made make VBN cord-349011-kxhpdvri 53 28 - - HYPH cord-349011-kxhpdvri 53 29 in in IN cord-349011-kxhpdvri 53 30 - - HYPH cord-349011-kxhpdvri 53 31 Canada Canada NNP cord-349011-kxhpdvri 53 32 " " `` cord-349011-kxhpdvri 53 33 Lassa Lassa NNP cord-349011-kxhpdvri 53 34 fever fever NN cord-349011-kxhpdvri 53 35 vaccine vaccine NN cord-349011-kxhpdvri 53 36 , , , cord-349011-kxhpdvri 53 37 which which WDT cord-349011-kxhpdvri 53 38 performed perform VBD cord-349011-kxhpdvri 53 39 well well RB cord-349011-kxhpdvri 53 40 in in IN cord-349011-kxhpdvri 53 41 guinea guinea NN cord-349011-kxhpdvri 53 42 pig pig NN cord-349011-kxhpdvri 53 43 , , , cord-349011-kxhpdvri 53 44 rhesus rhesu NNS cord-349011-kxhpdvri 53 45 and and CC cord-349011-kxhpdvri 53 46 cynomolgus cynomolgus NNP cord-349011-kxhpdvri 53 47 macaque macaque NN cord-349011-kxhpdvri 53 48 models model NNS cord-349011-kxhpdvri 53 49 [ [ -LRB- cord-349011-kxhpdvri 53 50 13 13 CD cord-349011-kxhpdvri 53 51 ] ] -RRB- cord-349011-kxhpdvri 53 52 [ [ -LRB- cord-349011-kxhpdvri 53 53 14 14 CD cord-349011-kxhpdvri 53 54 ] ] -RRB- cord-349011-kxhpdvri 53 55 [ [ -LRB- cord-349011-kxhpdvri 53 56 15 15 CD cord-349011-kxhpdvri 53 57 ] ] -RRB- cord-349011-kxhpdvri 53 58 . . . cord-349011-kxhpdvri 54 1 Dr. Dr. NNP cord-349011-kxhpdvri 54 2 Drebot Drebot NNP cord-349011-kxhpdvri 54 3 also also RB cord-349011-kxhpdvri 54 4 described describe VBD cord-349011-kxhpdvri 54 5 work work NN cord-349011-kxhpdvri 54 6 from from IN cord-349011-kxhpdvri 54 7 Dr. Dr. NNP cord-349011-kxhpdvri 54 8 David David NNP cord-349011-kxhpdvri 54 9 Safronetz Safronetz NNP cord-349011-kxhpdvri 54 10 and and CC cord-349011-kxhpdvri 54 11 other other JJ cord-349011-kxhpdvri 54 12 colleagues colleague NNS cord-349011-kxhpdvri 54 13 at at IN cord-349011-kxhpdvri 54 14 the the DT cord-349011-kxhpdvri 54 15 NML NML NNP cord-349011-kxhpdvri 54 16 who who WP cord-349011-kxhpdvri 54 17 are be VBP cord-349011-kxhpdvri 54 18 working work VBG cord-349011-kxhpdvri 54 19 on on IN cord-349011-kxhpdvri 54 20 the the DT cord-349011-kxhpdvri 54 21 next next JJ cord-349011-kxhpdvri 54 22 steps step NNS cord-349011-kxhpdvri 54 23 required require VBN cord-349011-kxhpdvri 54 24 to to TO cord-349011-kxhpdvri 54 25 bring bring VB cord-349011-kxhpdvri 54 26 this this DT cord-349011-kxhpdvri 54 27 vaccine vaccine NN cord-349011-kxhpdvri 54 28 to to IN cord-349011-kxhpdvri 54 29 clinical clinical JJ cord-349011-kxhpdvri 54 30 trials trial NNS cord-349011-kxhpdvri 54 31 . . . cord-349011-kxhpdvri 55 1 The the DT cord-349011-kxhpdvri 55 2 " " `` cord-349011-kxhpdvri 55 3 Emerging Emerging NNP cord-349011-kxhpdvri 55 4 Viruses Viruses NNPS cord-349011-kxhpdvri 55 5 " " '' cord-349011-kxhpdvri 55 6 session session NN cord-349011-kxhpdvri 55 7 also also RB cord-349011-kxhpdvri 55 8 included include VBD cord-349011-kxhpdvri 55 9 presentations presentation NNS cord-349011-kxhpdvri 55 10 from from IN cord-349011-kxhpdvri 55 11 the the DT cord-349011-kxhpdvri 55 12 following follow VBG cord-349011-kxhpdvri 55 13 trainees trainee NNS cord-349011-kxhpdvri 55 14 : : : cord-349011-kxhpdvri 56 1 Md Md NNP cord-349011-kxhpdvri 56 2 Niaz Niaz NNP cord-349011-kxhpdvri 56 3 Rahim Rahim NNP cord-349011-kxhpdvri 56 4 ( ( -LRB- cord-349011-kxhpdvri 56 5 University University NNP cord-349011-kxhpdvri 56 6 of of IN cord-349011-kxhpdvri 56 7 Manitoba Manitoba NNP cord-349011-kxhpdvri 56 8 ) ) -RRB- cord-349011-kxhpdvri 56 9 who who WP cord-349011-kxhpdvri 56 10 discussed discuss VBD cord-349011-kxhpdvri 56 11 a a DT cord-349011-kxhpdvri 56 12 pan pan JJ cord-349011-kxhpdvri 56 13 - - JJ cord-349011-kxhpdvri 56 14 filovirus filovirus NN cord-349011-kxhpdvri 56 15 T t NN cord-349011-kxhpdvri 56 16 - - HYPH cord-349011-kxhpdvri 56 17 cell cell NN cord-349011-kxhpdvri 56 18 vaccine vaccine NN cord-349011-kxhpdvri 56 19 for for IN cord-349011-kxhpdvri 56 20 Ebola Ebola NNP cord-349011-kxhpdvri 56 21 and and CC cord-349011-kxhpdvri 56 22 Marburg Marburg NNP cord-349011-kxhpdvri 56 23 viruses virus NNS cord-349011-kxhpdvri 56 24 , , , cord-349011-kxhpdvri 56 25 Corina Corina NNP cord-349011-kxhpdvri 56 26 Warkentin Warkentin NNP cord-349011-kxhpdvri 56 27 ( ( -LRB- cord-349011-kxhpdvri 56 28 University University NNP cord-349011-kxhpdvri 56 29 of of IN cord-349011-kxhpdvri 56 30 Ottawa Ottawa NNP cord-349011-kxhpdvri 56 31 ) ) -RRB- cord-349011-kxhpdvri 56 32 who who WP cord-349011-kxhpdvri 56 33 discussed discuss VBD cord-349011-kxhpdvri 56 34 roles role NNS cord-349011-kxhpdvri 56 35 for for IN cord-349011-kxhpdvri 56 36 kinases kinase NNS cord-349011-kxhpdvri 56 37 in in IN cord-349011-kxhpdvri 56 38 filovirus filovirus NN cord-349011-kxhpdvri 56 39 entry entry NN cord-349011-kxhpdvri 56 40 pathways pathway NNS cord-349011-kxhpdvri 56 41 , , , cord-349011-kxhpdvri 56 42 and and CC cord-349011-kxhpdvri 56 43 Neda Neda NNP cord-349011-kxhpdvri 56 44 Barjesteh Barjesteh NNP cord-349011-kxhpdvri 56 45 ( ( -LRB- cord-349011-kxhpdvri 56 46 McMaster McMaster NNP cord-349011-kxhpdvri 56 47 University University NNP cord-349011-kxhpdvri 56 48 ) ) -RRB- cord-349011-kxhpdvri 56 49 who who WP cord-349011-kxhpdvri 56 50 discussed discuss VBD cord-349011-kxhpdvri 56 51 links link NNS cord-349011-kxhpdvri 56 52 between between IN cord-349011-kxhpdvri 56 53 viral viral JJ cord-349011-kxhpdvri 56 54 infection infection NN cord-349011-kxhpdvri 56 55 and and CC cord-349011-kxhpdvri 56 56 Amyotrophic Amyotrophic NNP cord-349011-kxhpdvri 56 57 Lateral Lateral NNP cord-349011-kxhpdvri 56 58 Sclerosis Sclerosis NNP cord-349011-kxhpdvri 56 59 . . . cord-349011-kxhpdvri 57 1 The the DT cord-349011-kxhpdvri 57 2 next next JJ cord-349011-kxhpdvri 57 3 session session NN cord-349011-kxhpdvri 57 4 on on IN cord-349011-kxhpdvri 57 5 " " `` cord-349011-kxhpdvri 57 6 Viral viral JJ cord-349011-kxhpdvri 57 7 Subversion subversion NN cord-349011-kxhpdvri 57 8 of of IN cord-349011-kxhpdvri 57 9 Host Host NNP cord-349011-kxhpdvri 57 10 Cell Cell NNP cord-349011-kxhpdvri 57 11 Processes Processes NNPS cord-349011-kxhpdvri 57 12 " " '' cord-349011-kxhpdvri 57 13 opened open VBD cord-349011-kxhpdvri 57 14 with with IN cord-349011-kxhpdvri 57 15 a a DT cord-349011-kxhpdvri 57 16 talk talk NN cord-349011-kxhpdvri 57 17 on on IN cord-349011-kxhpdvri 57 18 herpesvirus herpesvirus NNP cord-349011-kxhpdvri 57 19 assembly assembly NN cord-349011-kxhpdvri 57 20 from from IN cord-349011-kxhpdvri 57 21 Dr. Dr. NNP cord-349011-kxhpdvri 57 22 Bruce Bruce NNP cord-349011-kxhpdvri 57 23 Banfield Banfield NNP cord-349011-kxhpdvri 57 24 ( ( -LRB- cord-349011-kxhpdvri 57 25 Queens Queens NNP cord-349011-kxhpdvri 57 26 University University NNP cord-349011-kxhpdvri 57 27 ) ) -RRB- cord-349011-kxhpdvri 57 28 . . . cord-349011-kxhpdvri 58 1 Herpesviruses Herpesviruses NNP cord-349011-kxhpdvri 58 2 replicate replicate VBP cord-349011-kxhpdvri 58 3 in in IN cord-349011-kxhpdvri 58 4 the the DT cord-349011-kxhpdvri 58 5 cell cell NN cord-349011-kxhpdvri 58 6 nucleus nucleus NN cord-349011-kxhpdvri 58 7 , , , cord-349011-kxhpdvri 58 8 where where WRB cord-349011-kxhpdvri 58 9 the the DT cord-349011-kxhpdvri 58 10 viral viral JJ cord-349011-kxhpdvri 58 11 genome genome NN cord-349011-kxhpdvri 58 12 is be VBZ cord-349011-kxhpdvri 58 13 copied copy VBN cord-349011-kxhpdvri 58 14 into into IN cord-349011-kxhpdvri 58 15 branched branched JJ cord-349011-kxhpdvri 58 16 concatemers concatemer NNS cord-349011-kxhpdvri 58 17 that that WDT cord-349011-kxhpdvri 58 18 are be VBP cord-349011-kxhpdvri 58 19 trimmed trim VBN cord-349011-kxhpdvri 58 20 and and CC cord-349011-kxhpdvri 58 21 packaged package VBN cord-349011-kxhpdvri 58 22 into into IN cord-349011-kxhpdvri 58 23 newly newly RB cord-349011-kxhpdvri 58 24 assembled assemble VBN cord-349011-kxhpdvri 58 25 procapsids procapsid NNS cord-349011-kxhpdvri 58 26 . . . cord-349011-kxhpdvri 59 1 Because because IN cord-349011-kxhpdvri 59 2 these these DT cord-349011-kxhpdvri 59 3 DNA dna NN cord-349011-kxhpdvri 59 4 - - HYPH cord-349011-kxhpdvri 59 5 containing contain VBG cord-349011-kxhpdvri 59 6 capsids capsid NNS cord-349011-kxhpdvri 59 7 are be VBP cord-349011-kxhpdvri 59 8 too too RB cord-349011-kxhpdvri 59 9 large large JJ cord-349011-kxhpdvri 59 10 to to TO cord-349011-kxhpdvri 59 11 exit exit VB cord-349011-kxhpdvri 59 12 the the DT cord-349011-kxhpdvri 59 13 nucleus nucleus NN cord-349011-kxhpdvri 59 14 via via IN cord-349011-kxhpdvri 59 15 nuclear nuclear JJ cord-349011-kxhpdvri 59 16 pores pore NNS cord-349011-kxhpdvri 59 17 , , , cord-349011-kxhpdvri 59 18 herpesviruses herpesviruses NNP cord-349011-kxhpdvri 59 19 must must MD cord-349011-kxhpdvri 59 20 transit transit VB cord-349011-kxhpdvri 59 21 the the DT cord-349011-kxhpdvri 59 22 nuclear nuclear JJ cord-349011-kxhpdvri 59 23 envelope envelope NN cord-349011-kxhpdvri 59 24 to to TO cord-349011-kxhpdvri 59 25 access access VB cord-349011-kxhpdvri 59 26 the the DT cord-349011-kxhpdvri 59 27 cytoplasm cytoplasm NN cord-349011-kxhpdvri 59 28 where where WRB cord-349011-kxhpdvri 59 29 the the DT cord-349011-kxhpdvri 59 30 final final JJ cord-349011-kxhpdvri 59 31 stages stage NNS cord-349011-kxhpdvri 59 32 of of IN cord-349011-kxhpdvri 59 33 virion virion NN cord-349011-kxhpdvri 59 34 maturation maturation NN cord-349011-kxhpdvri 59 35 occur occur VBP cord-349011-kxhpdvri 59 36 . . . cord-349011-kxhpdvri 60 1 This this DT cord-349011-kxhpdvri 60 2 process process NN cord-349011-kxhpdvri 60 3 , , , cord-349011-kxhpdvri 60 4 called call VBN cord-349011-kxhpdvri 60 5 nuclear nuclear JJ cord-349011-kxhpdvri 60 6 egress egress NN cord-349011-kxhpdvri 60 7 , , , cord-349011-kxhpdvri 60 8 is be VBZ cord-349011-kxhpdvri 60 9 achieved achieve VBN cord-349011-kxhpdvri 60 10 by by IN cord-349011-kxhpdvri 60 11 budding bud VBG cord-349011-kxhpdvri 60 12 of of IN cord-349011-kxhpdvri 60 13 capsids capsid NNS cord-349011-kxhpdvri 60 14 into into IN cord-349011-kxhpdvri 60 15 the the DT cord-349011-kxhpdvri 60 16 inner inner JJ cord-349011-kxhpdvri 60 17 nuclear nuclear JJ cord-349011-kxhpdvri 60 18 membrane membrane NN cord-349011-kxhpdvri 60 19 yielding yield VBG cord-349011-kxhpdvri 60 20 an an DT cord-349011-kxhpdvri 60 21 enveloped envelop VBN cord-349011-kxhpdvri 60 22 particle particle NN cord-349011-kxhpdvri 60 23 in in IN cord-349011-kxhpdvri 60 24 the the DT cord-349011-kxhpdvri 60 25 perinuclear perinuclear NNP cord-349011-kxhpdvri 60 26 space space NN cord-349011-kxhpdvri 60 27 . . . cord-349011-kxhpdvri 61 1 The the DT cord-349011-kxhpdvri 61 2 envelopes envelope NNS cord-349011-kxhpdvri 61 3 of of IN cord-349011-kxhpdvri 61 4 these these DT cord-349011-kxhpdvri 61 5 perinuclear perinuclear NNP cord-349011-kxhpdvri 61 6 virions virion NNS cord-349011-kxhpdvri 61 7 then then RB cord-349011-kxhpdvri 61 8 fuse fuse VB cord-349011-kxhpdvri 61 9 with with IN cord-349011-kxhpdvri 61 10 the the DT cord-349011-kxhpdvri 61 11 outer outer JJ cord-349011-kxhpdvri 61 12 nuclear nuclear JJ cord-349011-kxhpdvri 61 13 membrane membrane NN cord-349011-kxhpdvri 61 14 releasing release VBG cord-349011-kxhpdvri 61 15 DNA dna NN cord-349011-kxhpdvri 61 16 - - HYPH cord-349011-kxhpdvri 61 17 containing contain VBG cord-349011-kxhpdvri 61 18 capsids capsid NNS cord-349011-kxhpdvri 61 19 into into IN cord-349011-kxhpdvri 61 20 the the DT cord-349011-kxhpdvri 61 21 cytoplasm cytoplasm NN cord-349011-kxhpdvri 61 22 . . . cord-349011-kxhpdvri 62 1 Although although IN cord-349011-kxhpdvri 62 2 this this DT cord-349011-kxhpdvri 62 3 fusion fusion NN cord-349011-kxhpdvri 62 4 mechanism mechanism NN cord-349011-kxhpdvri 62 5 is be VBZ cord-349011-kxhpdvri 62 6 poorly poorly RB cord-349011-kxhpdvri 62 7 understood understand VBN cord-349011-kxhpdvri 62 8 , , , cord-349011-kxhpdvri 62 9 several several JJ cord-349011-kxhpdvri 62 10 groups group NNS cord-349011-kxhpdvri 62 11 have have VBP cord-349011-kxhpdvri 62 12 partially partially RB cord-349011-kxhpdvri 62 13 described describe VBN cord-349011-kxhpdvri 62 14 the the DT cord-349011-kxhpdvri 62 15 remarkable remarkable JJ cord-349011-kxhpdvri 62 16 mechanism mechanism NN cord-349011-kxhpdvri 62 17 of of IN cord-349011-kxhpdvri 62 18 budding budding NN cord-349011-kxhpdvri 62 19 , , , cord-349011-kxhpdvri 62 20 whereby whereby WRB cord-349011-kxhpdvri 62 21 two two CD cord-349011-kxhpdvri 62 22 conserved conserve VBN cord-349011-kxhpdvri 62 23 viral viral JJ cord-349011-kxhpdvri 62 24 proteins protein NNS cord-349011-kxhpdvri 62 25 , , , cord-349011-kxhpdvri 62 26 pUL31 pUL31 NNP cord-349011-kxhpdvri 62 27 and and CC cord-349011-kxhpdvri 62 28 pUL34 pUL34 NNP cord-349011-kxhpdvri 62 29 , , , cord-349011-kxhpdvri 62 30 assemble assemble VB cord-349011-kxhpdvri 62 31 into into IN cord-349011-kxhpdvri 62 32 an an DT cord-349011-kxhpdvri 62 33 oligomeric oligomeric JJ cord-349011-kxhpdvri 62 34 nuclear nuclear JJ cord-349011-kxhpdvri 62 35 egress egress NN cord-349011-kxhpdvri 62 36 complex complex NN cord-349011-kxhpdvri 62 37 ( ( -LRB- cord-349011-kxhpdvri 62 38 NEC NEC NNP cord-349011-kxhpdvri 62 39 ) ) -RRB- cord-349011-kxhpdvri 62 40 on on IN cord-349011-kxhpdvri 62 41 the the DT cord-349011-kxhpdvri 62 42 inner inner JJ cord-349011-kxhpdvri 62 43 nuclear nuclear JJ cord-349011-kxhpdvri 62 44 membrane membrane NN cord-349011-kxhpdvri 62 45 and and CC cord-349011-kxhpdvri 62 46 facilitate facilitate VB cord-349011-kxhpdvri 62 47 capsid capsid NN cord-349011-kxhpdvri 62 48 recruitment recruitment NN cord-349011-kxhpdvri 62 49 and and CC cord-349011-kxhpdvri 62 50 budding bud VBG cord-349011-kxhpdvri 62 51 into into IN cord-349011-kxhpdvri 62 52 the the DT cord-349011-kxhpdvri 62 53 perinuclear perinuclear JJ cord-349011-kxhpdvri 62 54 space space NN cord-349011-kxhpdvri 62 55 [ [ -LRB- cord-349011-kxhpdvri 62 56 16 16 CD cord-349011-kxhpdvri 62 57 , , , cord-349011-kxhpdvri 62 58 17 17 CD cord-349011-kxhpdvri 62 59 ] ] -RRB- cord-349011-kxhpdvri 62 60 . . . cord-349011-kxhpdvri 63 1 Dr. Dr. NNP cord-349011-kxhpdvri 63 2 Banfield Banfield NNP cord-349011-kxhpdvri 63 3 described describe VBD cord-349011-kxhpdvri 63 4 the the DT cord-349011-kxhpdvri 63 5 herpes herpes NNP cord-349011-kxhpdvri 63 6 simplex simplex NNP cord-349011-kxhpdvri 63 7 virus virus NN cord-349011-kxhpdvri 63 8 type-2 type-2 NN cord-349011-kxhpdvri 64 1 ( ( -LRB- cord-349011-kxhpdvri 64 2 HSV-2 HSV-2 NNP cord-349011-kxhpdvri 64 3 ) ) -RRB- cord-349011-kxhpdvri 64 4 NEC NEC NNP cord-349011-kxhpdvri 64 5 complex complex NN cord-349011-kxhpdvri 64 6 , , , cord-349011-kxhpdvri 64 7 which which WDT cord-349011-kxhpdvri 64 8 is be VBZ cord-349011-kxhpdvri 64 9 sufficient sufficient JJ cord-349011-kxhpdvri 64 10 to to TO cord-349011-kxhpdvri 64 11 promote promote VB cord-349011-kxhpdvri 64 12 nuclear nuclear JJ cord-349011-kxhpdvri 64 13 envelope envelope NN cord-349011-kxhpdvri 64 14 vesiculation vesiculation NN cord-349011-kxhpdvri 64 15 and and CC cord-349011-kxhpdvri 64 16 drive drive VB cord-349011-kxhpdvri 64 17 nucleoplasmic nucleoplasmic JJ cord-349011-kxhpdvri 64 18 invagination invagination NN cord-349011-kxhpdvri 64 19 of of IN cord-349011-kxhpdvri 64 20 the the DT cord-349011-kxhpdvri 64 21 inner inner JJ cord-349011-kxhpdvri 64 22 nuclear nuclear JJ cord-349011-kxhpdvri 64 23 membrane membrane NN cord-349011-kxhpdvri 64 24 in in IN cord-349011-kxhpdvri 64 25 transfected transfected JJ cord-349011-kxhpdvri 64 26 cells cell NNS cord-349011-kxhpdvri 64 27 . . . cord-349011-kxhpdvri 65 1 However however RB cord-349011-kxhpdvri 65 2 , , , cord-349011-kxhpdvri 65 3 these these DT cord-349011-kxhpdvri 65 4 nuclear nuclear JJ cord-349011-kxhpdvri 65 5 envelope envelope NN cord-349011-kxhpdvri 65 6 perturbations perturbation NNS cord-349011-kxhpdvri 65 7 are be VBP cord-349011-kxhpdvri 65 8 not not RB cord-349011-kxhpdvri 65 9 normally normally RB cord-349011-kxhpdvri 65 10 seen see VBN cord-349011-kxhpdvri 65 11 in in IN cord-349011-kxhpdvri 65 12 cells cell NNS cord-349011-kxhpdvri 65 13 infected infect VBN cord-349011-kxhpdvri 65 14 with with IN cord-349011-kxhpdvri 65 15 wild wild JJ cord-349011-kxhpdvri 65 16 - - HYPH cord-349011-kxhpdvri 65 17 type type NN cord-349011-kxhpdvri 65 18 HSV-2 hsv-2 NN cord-349011-kxhpdvri 65 19 strains strain NNS cord-349011-kxhpdvri 65 20 suggesting suggest VBG cord-349011-kxhpdvri 65 21 that that IN cord-349011-kxhpdvri 65 22 these these DT cord-349011-kxhpdvri 65 23 NEC NEC NNP cord-349011-kxhpdvri 65 24 activities activity NNS cord-349011-kxhpdvri 65 25 are be VBP cord-349011-kxhpdvri 65 26 negatively negatively RB cord-349011-kxhpdvri 65 27 regulated regulate VBN cord-349011-kxhpdvri 65 28 during during IN cord-349011-kxhpdvri 65 29 infection infection NN cord-349011-kxhpdvri 65 30 . . . cord-349011-kxhpdvri 66 1 The the DT cord-349011-kxhpdvri 66 2 capacity capacity NN cord-349011-kxhpdvri 66 3 of of IN cord-349011-kxhpdvri 66 4 the the DT cord-349011-kxhpdvri 66 5 NEC NEC NNP cord-349011-kxhpdvri 66 6 to to TO cord-349011-kxhpdvri 66 7 drive drive VB cord-349011-kxhpdvri 66 8 the the DT cord-349011-kxhpdvri 66 9 formation formation NN cord-349011-kxhpdvri 66 10 of of IN cord-349011-kxhpdvri 66 11 long long JJ cord-349011-kxhpdvri 66 12 inner inner JJ cord-349011-kxhpdvri 66 13 nuclear nuclear JJ cord-349011-kxhpdvri 66 14 membrane membrane NN cord-349011-kxhpdvri 66 15 - - HYPH cord-349011-kxhpdvri 66 16 derived derive VBN cord-349011-kxhpdvri 66 17 tubules tubule NNS cord-349011-kxhpdvri 66 18 that that WDT cord-349011-kxhpdvri 66 19 extend extend VBP cord-349011-kxhpdvri 66 20 deep deep RB cord-349011-kxhpdvri 66 21 into into IN cord-349011-kxhpdvri 66 22 the the DT cord-349011-kxhpdvri 66 23 nucleus nucleus NN cord-349011-kxhpdvri 66 24 suggest suggest VBP cord-349011-kxhpdvri 66 25 that that IN cord-349011-kxhpdvri 66 26 capsid capsid NN cord-349011-kxhpdvri 66 27 envelopment envelopment NN cord-349011-kxhpdvri 66 28 could could MD cord-349011-kxhpdvri 66 29 , , , cord-349011-kxhpdvri 66 30 paradoxically paradoxically RB cord-349011-kxhpdvri 66 31 , , , cord-349011-kxhpdvri 66 32 occur occur VBP cord-349011-kxhpdvri 66 33 deeper deeply RBR cord-349011-kxhpdvri 66 34 in in IN cord-349011-kxhpdvri 66 35 the the DT cord-349011-kxhpdvri 66 36 nucleus nucleus NN cord-349011-kxhpdvri 66 37 rather rather RB cord-349011-kxhpdvri 66 38 than than IN cord-349011-kxhpdvri 66 39 at at IN cord-349011-kxhpdvri 66 40 the the DT cord-349011-kxhpdvri 66 41 nuclear nuclear JJ cord-349011-kxhpdvri 66 42 periphery periphery NN cord-349011-kxhpdvri 66 43 where where WRB cord-349011-kxhpdvri 66 44 marginalized marginalize VBN cord-349011-kxhpdvri 66 45 cellular cellular JJ cord-349011-kxhpdvri 66 46 chromatin chromatin NN cord-349011-kxhpdvri 66 47 and and CC cord-349011-kxhpdvri 66 48 the the DT cord-349011-kxhpdvri 66 49 nuclear nuclear JJ cord-349011-kxhpdvri 66 50 lamina lamina NN cord-349011-kxhpdvri 66 51 create create VB cord-349011-kxhpdvri 66 52 formidable formidable JJ cord-349011-kxhpdvri 66 53 barriers barrier NNS cord-349011-kxhpdvri 66 54 to to IN cord-349011-kxhpdvri 66 55 capsid capsid NN cord-349011-kxhpdvri 66 56 envelopment envelopment NN cord-349011-kxhpdvri 66 57 . . . cord-349011-kxhpdvri 67 1 pUL21 pUL21 NNP cord-349011-kxhpdvri 67 2 is be VBZ cord-349011-kxhpdvri 67 3 a a DT cord-349011-kxhpdvri 67 4 tegument tegument NN cord-349011-kxhpdvri 67 5 protein protein NN cord-349011-kxhpdvri 67 6 that that WDT cord-349011-kxhpdvri 67 7 is be VBZ cord-349011-kxhpdvri 67 8 required require VBN cord-349011-kxhpdvri 67 9 for for IN cord-349011-kxhpdvri 67 10 efficient efficient JJ cord-349011-kxhpdvri 67 11 nuclear nuclear JJ cord-349011-kxhpdvri 67 12 egress egress NN cord-349011-kxhpdvri 67 13 of of IN cord-349011-kxhpdvri 67 14 HSV-2 HSV-2 NNP cord-349011-kxhpdvri 67 15 capsids capsid NNS cord-349011-kxhpdvri 67 16 [ [ -LRB- cord-349011-kxhpdvri 67 17 18 18 CD cord-349011-kxhpdvri 67 18 ] ] -RRB- cord-349011-kxhpdvri 67 19 . . . cord-349011-kxhpdvri 68 1 New new JJ cord-349011-kxhpdvri 68 2 data datum NNS cord-349011-kxhpdvri 68 3 from from IN cord-349011-kxhpdvri 68 4 the the DT cord-349011-kxhpdvri 68 5 Banfield Banfield NNP cord-349011-kxhpdvri 68 6 lab lab NN cord-349011-kxhpdvri 68 7 demonstrated demonstrate VBD cord-349011-kxhpdvri 68 8 that that IN cord-349011-kxhpdvri 68 9 enveloped envelop VBD cord-349011-kxhpdvri 68 10 capsids capsid NNS cord-349011-kxhpdvri 68 11 accumulate accumulate VBP cord-349011-kxhpdvri 68 12 in in IN cord-349011-kxhpdvri 68 13 inner inner JJ cord-349011-kxhpdvri 68 14 nuclear nuclear JJ cord-349011-kxhpdvri 68 15 membrane membrane NN cord-349011-kxhpdvri 68 16 bound bind VBN cord-349011-kxhpdvri 68 17 structures structure NNS cord-349011-kxhpdvri 68 18 deep deep RB cord-349011-kxhpdvri 68 19 within within IN cord-349011-kxhpdvri 68 20 the the DT cord-349011-kxhpdvri 68 21 nucleus nucleus NN cord-349011-kxhpdvri 68 22 of of IN cord-349011-kxhpdvri 68 23 cells cell NNS cord-349011-kxhpdvri 68 24 infected infect VBN cord-349011-kxhpdvri 68 25 with with IN cord-349011-kxhpdvri 68 26 UL21 UL21 NNP cord-349011-kxhpdvri 68 27 mutant mutant JJ cord-349011-kxhpdvri 68 28 viruses virus NNS cord-349011-kxhpdvri 68 29 suggesting suggest VBG cord-349011-kxhpdvri 68 30 that that IN cord-349011-kxhpdvri 68 31 : : : cord-349011-kxhpdvri 68 32 1 1 LS cord-349011-kxhpdvri 68 33 ) ) -RRB- cord-349011-kxhpdvri 68 34 pUL21 pUL21 NNP cord-349011-kxhpdvri 68 35 negatively negatively RB cord-349011-kxhpdvri 68 36 regulates regulate VBZ cord-349011-kxhpdvri 68 37 the the DT cord-349011-kxhpdvri 68 38 inner inner JJ cord-349011-kxhpdvri 68 39 nuclear nuclear JJ cord-349011-kxhpdvri 68 40 membrane membrane NN cord-349011-kxhpdvri 68 41 invagination invagination NN cord-349011-kxhpdvri 68 42 activity activity NN cord-349011-kxhpdvri 68 43 of of IN cord-349011-kxhpdvri 68 44 the the DT cord-349011-kxhpdvri 68 45 HSV-2 HSV-2 NNP cord-349011-kxhpdvri 68 46 NEC NEC NNP cord-349011-kxhpdvri 68 47 ; ; : cord-349011-kxhpdvri 68 48 and and CC cord-349011-kxhpdvri 68 49 2 2 LS cord-349011-kxhpdvri 68 50 ) ) -RRB- cord-349011-kxhpdvri 68 51 that that IN cord-349011-kxhpdvri 68 52 inner inner JJ cord-349011-kxhpdvri 68 53 nuclear nuclear JJ cord-349011-kxhpdvri 68 54 membrane membrane NN cord-349011-kxhpdvri 68 55 invaginations invagination NNS cord-349011-kxhpdvri 68 56 can can MD cord-349011-kxhpdvri 68 57 serve serve VB cord-349011-kxhpdvri 68 58 as as IN cord-349011-kxhpdvri 68 59 sites site NNS cord-349011-kxhpdvri 68 60 of of IN cord-349011-kxhpdvri 68 61 capsid capsid NN cord-349011-kxhpdvri 68 62 envelopment envelopment NN cord-349011-kxhpdvri 68 63 . . . cord-349011-kxhpdvri 69 1 Mammalian mammalian JJ cord-349011-kxhpdvri 69 2 orthoreoviruses orthoreoviruse NNS cord-349011-kxhpdvri 69 3 selectively selectively RB cord-349011-kxhpdvri 69 4 replicate replicate VBP cord-349011-kxhpdvri 69 5 in in IN cord-349011-kxhpdvri 69 6 cancer cancer NN cord-349011-kxhpdvri 69 7 cells cell NNS cord-349011-kxhpdvri 69 8 and and CC cord-349011-kxhpdvri 69 9 have have VBP cord-349011-kxhpdvri 69 10 been be VBN cord-349011-kxhpdvri 69 11 extensively extensively RB cord-349011-kxhpdvri 69 12 studied study VBN cord-349011-kxhpdvri 69 13 as as IN cord-349011-kxhpdvri 69 14 oncolytic oncolytic JJ cord-349011-kxhpdvri 69 15 agents agent NNS cord-349011-kxhpdvri 69 16 in in IN cord-349011-kxhpdvri 69 17 animal animal NN cord-349011-kxhpdvri 69 18 models model NNS cord-349011-kxhpdvri 69 19 and and CC cord-349011-kxhpdvri 69 20 human human JJ cord-349011-kxhpdvri 69 21 clinical clinical JJ cord-349011-kxhpdvri 69 22 trials trial NNS cord-349011-kxhpdvri 69 23 [ [ -LRB- cord-349011-kxhpdvri 69 24 19 19 CD cord-349011-kxhpdvri 69 25 , , , cord-349011-kxhpdvri 69 26 20 20 CD cord-349011-kxhpdvri 69 27 ] ] -RRB- cord-349011-kxhpdvri 69 28 ) ) -RRB- cord-349011-kxhpdvri 69 29 . . . cord-349011-kxhpdvri 70 1 Dr. Dr. NNP cord-349011-kxhpdvri 70 2 Maya Maya NNP cord-349011-kxhpdvri 70 3 Shmulevitz Shmulevitz NNP cord-349011-kxhpdvri 70 4 ( ( -LRB- cord-349011-kxhpdvri 70 5 University University NNP cord-349011-kxhpdvri 70 6 of of IN cord-349011-kxhpdvri 70 7 Alberta Alberta NNP cord-349011-kxhpdvri 70 8 ) ) -RRB- cord-349011-kxhpdvri 70 9 described describe VBD cord-349011-kxhpdvri 70 10 how how WRB cord-349011-kxhpdvri 70 11 knowledge knowledge NN cord-349011-kxhpdvri 70 12 of of IN cord-349011-kxhpdvri 70 13 reovirus reovirus NNP cord-349011-kxhpdvri 70 14 molecular molecular JJ cord-349011-kxhpdvri 70 15 genetics genetic NNS cord-349011-kxhpdvri 70 16 can can MD cord-349011-kxhpdvri 70 17 be be VB cord-349011-kxhpdvri 70 18 exploited exploit VBN cord-349011-kxhpdvri 70 19 to to TO cord-349011-kxhpdvri 70 20 create create VB cord-349011-kxhpdvri 70 21 mutant mutant JJ cord-349011-kxhpdvri 70 22 viruses virus NNS cord-349011-kxhpdvri 70 23 that that WDT cord-349011-kxhpdvri 70 24 enter enter VBP cord-349011-kxhpdvri 70 25 and and CC cord-349011-kxhpdvri 70 26 kill kill VBP cord-349011-kxhpdvri 70 27 cancer cancer NN cord-349011-kxhpdvri 70 28 cells cell NNS cord-349011-kxhpdvri 70 29 more more RBR cord-349011-kxhpdvri 70 30 effectively effectively RB cord-349011-kxhpdvri 70 31 without without IN cord-349011-kxhpdvri 70 32 compromising compromise VBG cord-349011-kxhpdvri 70 33 their -PRON- PRP$ cord-349011-kxhpdvri 70 34 selectivity selectivity NN cord-349011-kxhpdvri 70 35 towards towards IN cord-349011-kxhpdvri 70 36 transformed transform VBN cord-349011-kxhpdvri 70 37 cells cell NNS cord-349011-kxhpdvri 70 38 [ [ -LRB- cord-349011-kxhpdvri 70 39 21 21 CD cord-349011-kxhpdvri 70 40 ] ] -RRB- cord-349011-kxhpdvri 70 41 . . . cord-349011-kxhpdvri 71 1 For for IN cord-349011-kxhpdvri 71 2 example example NN cord-349011-kxhpdvri 71 3 , , , cord-349011-kxhpdvri 71 4 while while IN cord-349011-kxhpdvri 71 5 virions virion NNS cord-349011-kxhpdvri 71 6 bearing bear VBG cord-349011-kxhpdvri 71 7 the the DT cord-349011-kxhpdvri 71 8 full full JJ cord-349011-kxhpdvri 71 9 complement complement NN cord-349011-kxhpdvri 71 10 of of IN cord-349011-kxhpdvri 71 11 twelve twelve CD cord-349011-kxhpdvri 71 12 trimeric trimeric NNP cord-349011-kxhpdvri 71 13 σ1 σ1 NNP cord-349011-kxhpdvri 71 14 attachment attachment NN cord-349011-kxhpdvri 71 15 protein protein NN cord-349011-kxhpdvri 71 16 complexes complex NNS cord-349011-kxhpdvri 71 17 on on IN cord-349011-kxhpdvri 71 18 their -PRON- PRP$ cord-349011-kxhpdvri 71 19 surfaces surface NNS cord-349011-kxhpdvri 71 20 are be VBP cord-349011-kxhpdvri 71 21 relatively relatively RB cord-349011-kxhpdvri 71 22 stable stable JJ cord-349011-kxhpdvri 71 23 in in IN cord-349011-kxhpdvri 71 24 the the DT cord-349011-kxhpdvri 71 25 natural natural JJ cord-349011-kxhpdvri 71 26 enteric enteric JJ cord-349011-kxhpdvri 71 27 environment environment NN cord-349011-kxhpdvri 71 28 , , , cord-349011-kxhpdvri 71 29 experimentally experimentally RB cord-349011-kxhpdvri 71 30 reducing reduce VBG cord-349011-kxhpdvri 71 31 the the DT cord-349011-kxhpdvri 71 32 number number NN cord-349011-kxhpdvri 71 33 of of IN cord-349011-kxhpdvri 71 34 these these DT cord-349011-kxhpdvri 71 35 attachment attachment NN cord-349011-kxhpdvri 71 36 proteins protein NNS cord-349011-kxhpdvri 71 37 on on IN cord-349011-kxhpdvri 71 38 the the DT cord-349011-kxhpdvri 71 39 virion virion NN cord-349011-kxhpdvri 71 40 accelerated accelerate VBD cord-349011-kxhpdvri 71 41 uncoating uncoating NN cord-349011-kxhpdvri 71 42 and and CC cord-349011-kxhpdvri 71 43 replication replication NN cord-349011-kxhpdvri 71 44 in in IN cord-349011-kxhpdvri 71 45 cancer cancer NN cord-349011-kxhpdvri 71 46 cells cell NNS cord-349011-kxhpdvri 71 47 and and CC cord-349011-kxhpdvri 71 48 increased increase VBD cord-349011-kxhpdvri 71 49 oncolytic oncolytic JJ cord-349011-kxhpdvri 71 50 potency potency NN cord-349011-kxhpdvri 71 51 in in IN cord-349011-kxhpdvri 71 52 a a DT cord-349011-kxhpdvri 71 53 mouse mouse NN cord-349011-kxhpdvri 71 54 melanoma melanoma NN cord-349011-kxhpdvri 71 55 model model NN cord-349011-kxhpdvri 71 56 [ [ -LRB- cord-349011-kxhpdvri 71 57 22 22 CD cord-349011-kxhpdvri 71 58 , , , cord-349011-kxhpdvri 71 59 23 23 CD cord-349011-kxhpdvri 71 60 ] ] -RRB- cord-349011-kxhpdvri 71 61 . . . cord-349011-kxhpdvri 72 1 Dr. Dr. NNP cord-349011-kxhpdvri 72 2 Shmulevitz Shmulevitz NNP cord-349011-kxhpdvri 72 3 also also RB cord-349011-kxhpdvri 72 4 described describe VBD cord-349011-kxhpdvri 72 5 how how WRB cord-349011-kxhpdvri 72 6 σ1 σ1 NNP cord-349011-kxhpdvri 72 7 attachment attachment NN cord-349011-kxhpdvri 72 8 protein protein NN cord-349011-kxhpdvri 72 9 cleavage cleavage NN cord-349011-kxhpdvri 72 10 by by IN cord-349011-kxhpdvri 72 11 breast breast NN cord-349011-kxhpdvri 72 12 cancer cancer NN cord-349011-kxhpdvri 72 13 metalloproteases metalloprotease NNS cord-349011-kxhpdvri 72 14 dramatically dramatically RB cord-349011-kxhpdvri 72 15 lowered lower VBD cord-349011-kxhpdvri 72 16 reovirus reovirus NN cord-349011-kxhpdvri 72 17 infectivity infectivity NN cord-349011-kxhpdvri 72 18 . . . cord-349011-kxhpdvri 73 1 Mutagenesis Mutagenesis NNP cord-349011-kxhpdvri 73 2 of of IN cord-349011-kxhpdvri 73 3 defined define VBN cord-349011-kxhpdvri 73 4 protease protease NN cord-349011-kxhpdvri 73 5 cleavage cleavage NN cord-349011-kxhpdvri 73 6 sites site NNS cord-349011-kxhpdvri 73 7 on on IN cord-349011-kxhpdvri 73 8 σ1 σ1 NNP cord-349011-kxhpdvri 73 9 prevented prevent VBD cord-349011-kxhpdvri 73 10 cleavage cleavage NN cord-349011-kxhpdvri 73 11 and and CC cord-349011-kxhpdvri 73 12 inactivation inactivation NN cord-349011-kxhpdvri 73 13 of of IN cord-349011-kxhpdvri 73 14 reoviruses reovirus NNS cord-349011-kxhpdvri 73 15 by by IN cord-349011-kxhpdvri 73 16 breast breast NN cord-349011-kxhpdvri 73 17 tumor tumor NN cord-349011-kxhpdvri 73 18 metalloproteases metalloprotease NNS cord-349011-kxhpdvri 73 19 . . . cord-349011-kxhpdvri 74 1 These these DT cord-349011-kxhpdvri 74 2 studies study NNS cord-349011-kxhpdvri 74 3 suggest suggest VBP cord-349011-kxhpdvri 74 4 that that IN cord-349011-kxhpdvri 74 5 reoviruses reovirus NNS cord-349011-kxhpdvri 74 6 are be VBP cord-349011-kxhpdvri 74 7 quite quite RB cord-349011-kxhpdvri 74 8 amenable amenable JJ cord-349011-kxhpdvri 74 9 to to IN cord-349011-kxhpdvri 74 10 repurposing repurpose VBG cord-349011-kxhpdvri 74 11 for for IN cord-349011-kxhpdvri 74 12 superior superior JJ cord-349011-kxhpdvri 74 13 oncolytic oncolytic JJ cord-349011-kxhpdvri 74 14 properties property NNS cord-349011-kxhpdvri 74 15 . . . cord-349011-kxhpdvri 75 1 The the DT cord-349011-kxhpdvri 75 2 " " `` cord-349011-kxhpdvri 75 3 Viral Viral NNP cord-349011-kxhpdvri 75 4 Subversion subversion NN cord-349011-kxhpdvri 75 5 of of IN cord-349011-kxhpdvri 75 6 Host Host NNP cord-349011-kxhpdvri 75 7 Cell cell NN cord-349011-kxhpdvri 75 8 Processes Processes NNPS cord-349011-kxhpdvri 75 9 " " '' cord-349011-kxhpdvri 75 10 session session NN cord-349011-kxhpdvri 75 11 also also RB cord-349011-kxhpdvri 75 12 included include VBD cord-349011-kxhpdvri 75 13 presentations presentation NNS cord-349011-kxhpdvri 75 14 from from IN cord-349011-kxhpdvri 75 15 the the DT cord-349011-kxhpdvri 75 16 following follow VBG cord-349011-kxhpdvri 75 17 trainees trainee NNS cord-349011-kxhpdvri 75 18 : : : cord-349011-kxhpdvri 76 1 Nichole Nichole NNP cord-349011-kxhpdvri 76 2 McMullen McMullen NNP cord-349011-kxhpdvri 76 3 ( ( -LRB- cord-349011-kxhpdvri 76 4 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 76 5 University University NNP cord-349011-kxhpdvri 76 6 ) ) -RRB- cord-349011-kxhpdvri 76 7 who who WP cord-349011-kxhpdvri 76 8 reported report VBD cord-349011-kxhpdvri 76 9 the the DT cord-349011-kxhpdvri 76 10 unconventional unconventional JJ cord-349011-kxhpdvri 76 11 egress egress NN cord-349011-kxhpdvri 76 12 mechanisms mechanism NNS cord-349011-kxhpdvri 76 13 of of IN cord-349011-kxhpdvri 76 14 non non JJ cord-349011-kxhpdvri 76 15 - - JJ cord-349011-kxhpdvri 76 16 enveloped enveloped JJ cord-349011-kxhpdvri 76 17 reoviruses reovirus NNS cord-349011-kxhpdvri 76 18 , , , cord-349011-kxhpdvri 76 19 Justine Justine NNP cord-349011-kxhpdvri 76 20 Sitz Sitz NNP cord-349011-kxhpdvri 76 21 ( ( -LRB- cord-349011-kxhpdvri 76 22 Université Université NNP cord-349011-kxhpdvri 76 23 Laval Laval NNP cord-349011-kxhpdvri 76 24 ) ) -RRB- cord-349011-kxhpdvri 76 25 who who WP cord-349011-kxhpdvri 76 26 described describe VBD cord-349011-kxhpdvri 76 27 interactions interaction NNS cord-349011-kxhpdvri 76 28 between between IN cord-349011-kxhpdvri 76 29 a a DT cord-349011-kxhpdvri 76 30 human human JJ cord-349011-kxhpdvri 76 31 papillomavirus papillomavirus NN cord-349011-kxhpdvri 76 32 protein protein NN cord-349011-kxhpdvri 76 33 and and CC cord-349011-kxhpdvri 76 34 a a DT cord-349011-kxhpdvri 76 35 host host NN cord-349011-kxhpdvri 76 36 DNA dna NN cord-349011-kxhpdvri 76 37 repair repair NN cord-349011-kxhpdvri 76 38 - - HYPH cord-349011-kxhpdvri 76 39 specific specific JJ cord-349011-kxhpdvri 76 40 E3 e3 NN cord-349011-kxhpdvri 76 41 ubiquitin ubiquitin NN cord-349011-kxhpdvri 76 42 ligase ligase NN cord-349011-kxhpdvri 76 43 , , , cord-349011-kxhpdvri 76 44 and and CC cord-349011-kxhpdvri 76 45 Quentin Quentin NNP cord-349011-kxhpdvri 76 46 Osseman Osseman NNP cord-349011-kxhpdvri 76 47 ( ( -LRB- cord-349011-kxhpdvri 76 48 Université Université NNP cord-349011-kxhpdvri 76 49 de de NNP cord-349011-kxhpdvri 76 50 Montréal Montréal NNP cord-349011-kxhpdvri 76 51 ) ) -RRB- cord-349011-kxhpdvri 76 52 who who WP cord-349011-kxhpdvri 76 53 described describe VBD cord-349011-kxhpdvri 76 54 interactions interaction NNS cord-349011-kxhpdvri 76 55 between between IN cord-349011-kxhpdvri 76 56 respiratory respiratory JJ cord-349011-kxhpdvri 76 57 syncytial syncytial JJ cord-349011-kxhpdvri 76 58 virus virus NN cord-349011-kxhpdvri 76 59 ( ( -LRB- cord-349011-kxhpdvri 76 60 RSV RSV NNP cord-349011-kxhpdvri 76 61 ) ) -RRB- cord-349011-kxhpdvri 76 62 and and CC cord-349011-kxhpdvri 76 63 the the DT cord-349011-kxhpdvri 76 64 host host NN cord-349011-kxhpdvri 76 65 autophagy autophagy NN cord-349011-kxhpdvri 76 66 pathway pathway NN cord-349011-kxhpdvri 76 67 . . . cord-349011-kxhpdvri 77 1 Following follow VBG cord-349011-kxhpdvri 77 2 this this DT cord-349011-kxhpdvri 77 3 session session NN cord-349011-kxhpdvri 77 4 , , , cord-349011-kxhpdvri 77 5 the the DT cord-349011-kxhpdvri 77 6 CSV csv NN cord-349011-kxhpdvri 77 7 conducted conduct VBD cord-349011-kxhpdvri 77 8 its -PRON- PRP$ cord-349011-kxhpdvri 77 9 first first JJ cord-349011-kxhpdvri 77 10 face face NN cord-349011-kxhpdvri 77 11 - - HYPH cord-349011-kxhpdvri 77 12 to to IN cord-349011-kxhpdvri 77 13 - - HYPH cord-349011-kxhpdvri 77 14 face face NN cord-349011-kxhpdvri 77 15 Business Business NNP cord-349011-kxhpdvri 77 16 Meeting Meeting NNP cord-349011-kxhpdvri 77 17 , , , cord-349011-kxhpdvri 77 18 where where WRB cord-349011-kxhpdvri 77 19 members member NNS cord-349011-kxhpdvri 77 20 learned learn VBD cord-349011-kxhpdvri 77 21 about about IN cord-349011-kxhpdvri 77 22 the the DT cord-349011-kxhpdvri 77 23 state state NN cord-349011-kxhpdvri 77 24 of of IN cord-349011-kxhpdvri 77 25 the the DT cord-349011-kxhpdvri 77 26 society society NN cord-349011-kxhpdvri 77 27 budget budget NN cord-349011-kxhpdvri 77 28 and and CC cord-349011-kxhpdvri 77 29 adopted adopt VBD cord-349011-kxhpdvri 77 30 a a DT cord-349011-kxhpdvri 77 31 set set NN cord-349011-kxhpdvri 77 32 of of IN cord-349011-kxhpdvri 77 33 by by IN cord-349011-kxhpdvri 77 34 - - HYPH cord-349011-kxhpdvri 77 35 laws law NNS cord-349011-kxhpdvri 77 36 . . . cord-349011-kxhpdvri 78 1 CSV CSV NNP cord-349011-kxhpdvri 78 2 symposia symposium NNS cord-349011-kxhpdvri 78 3 and and CC cord-349011-kxhpdvri 78 4 trainee trainee NN cord-349011-kxhpdvri 78 5 - - HYPH cord-349011-kxhpdvri 78 6 focused focus VBN cord-349011-kxhpdvri 78 7 opportunities opportunity NNS cord-349011-kxhpdvri 78 8 were be VBD cord-349011-kxhpdvri 78 9 discussed discuss VBN cord-349011-kxhpdvri 78 10 , , , cord-349011-kxhpdvri 78 11 as as RB cord-349011-kxhpdvri 78 12 well well RB cord-349011-kxhpdvri 78 13 as as IN cord-349011-kxhpdvri 78 14 imminent imminent JJ cord-349011-kxhpdvri 78 15 plans plan NNS cord-349011-kxhpdvri 78 16 for for IN cord-349011-kxhpdvri 78 17 the the DT cord-349011-kxhpdvri 78 18 first first JJ cord-349011-kxhpdvri 78 19 open open JJ cord-349011-kxhpdvri 78 20 election election NN cord-349011-kxhpdvri 78 21 of of IN cord-349011-kxhpdvri 78 22 a a DT cord-349011-kxhpdvri 78 23 CSV csv NN cord-349011-kxhpdvri 78 24 executive executive NN cord-349011-kxhpdvri 78 25 from from IN cord-349011-kxhpdvri 78 26 the the DT cord-349011-kxhpdvri 78 27 membership membership NN cord-349011-kxhpdvri 78 28 ( ( -LRB- cord-349011-kxhpdvri 78 29 which which WDT cord-349011-kxhpdvri 78 30 was be VBD cord-349011-kxhpdvri 78 31 completed complete VBN cord-349011-kxhpdvri 78 32 in in IN cord-349011-kxhpdvri 78 33 late late JJ cord-349011-kxhpdvri 78 34 2018 2018 CD cord-349011-kxhpdvri 78 35 ) ) -RRB- cord-349011-kxhpdvri 78 36 . . . cord-349011-kxhpdvri 79 1 Meanwhile meanwhile RB cord-349011-kxhpdvri 79 2 , , , cord-349011-kxhpdvri 79 3 in in IN cord-349011-kxhpdvri 79 4 another another DT cord-349011-kxhpdvri 79 5 theatre theatre NN cord-349011-kxhpdvri 79 6 , , , cord-349011-kxhpdvri 79 7 many many JJ cord-349011-kxhpdvri 79 8 of of IN cord-349011-kxhpdvri 79 9 the the DT cord-349011-kxhpdvri 79 10 trainee trainee NN cord-349011-kxhpdvri 79 11 attendees attendee NNS cord-349011-kxhpdvri 79 12 were be VBD cord-349011-kxhpdvri 79 13 treated treat VBN cord-349011-kxhpdvri 79 14 to to IN cord-349011-kxhpdvri 79 15 a a DT cord-349011-kxhpdvri 79 16 Writing Writing NNP cord-349011-kxhpdvri 79 17 Workshop Workshop NNP cord-349011-kxhpdvri 79 18 designed design VBN cord-349011-kxhpdvri 79 19 by by IN cord-349011-kxhpdvri 79 20 science science NN cord-349011-kxhpdvri 79 21 writer writer NN cord-349011-kxhpdvri 79 22 Alan Alan NNP cord-349011-kxhpdvri 79 23 Dove Dove NNP cord-349011-kxhpdvri 79 24 , , , cord-349011-kxhpdvri 79 25 PLoS PLoS NNP cord-349011-kxhpdvri 79 26 Pathogens Pathogens NNPS cord-349011-kxhpdvri 79 27 editor editor NN cord-349011-kxhpdvri 79 28 Karen Karen NNP cord-349011-kxhpdvri 79 29 Mossman Mossman NNP cord-349011-kxhpdvri 79 30 and and CC cord-349011-kxhpdvri 79 31 PLoS PLoS NNP cord-349011-kxhpdvri 79 32 ONE one CD cord-349011-kxhpdvri 79 33 senior senior JJ cord-349011-kxhpdvri 79 34 editor editor NN cord-349011-kxhpdvri 79 35 Eileen Eileen NNP cord-349011-kxhpdvri 79 36 Clancy Clancy NNP cord-349011-kxhpdvri 79 37 , , , cord-349011-kxhpdvri 79 38 who who WP cord-349011-kxhpdvri 79 39 presented present VBD cord-349011-kxhpdvri 79 40 strategies strategy NNS cord-349011-kxhpdvri 79 41 to to TO cord-349011-kxhpdvri 79 42 communicate communicate VB cord-349011-kxhpdvri 79 43 scientific scientific JJ cord-349011-kxhpdvri 79 44 discoveries discovery NNS cord-349011-kxhpdvri 79 45 effectively effectively RB cord-349011-kxhpdvri 79 46 in in IN cord-349011-kxhpdvri 79 47 writing writing NN cord-349011-kxhpdvri 79 48 . . . cord-349011-kxhpdvri 80 1 Particular particular JJ cord-349011-kxhpdvri 80 2 attention attention NN cord-349011-kxhpdvri 80 3 was be VBD cord-349011-kxhpdvri 80 4 paid pay VBN cord-349011-kxhpdvri 80 5 to to IN cord-349011-kxhpdvri 80 6 making make VBG cord-349011-kxhpdvri 80 7 a a DT cord-349011-kxhpdvri 80 8 compelling compelling JJ cord-349011-kxhpdvri 80 9 case case NN cord-349011-kxhpdvri 80 10 for for IN cord-349011-kxhpdvri 80 11 the the DT cord-349011-kxhpdvri 80 12 importance importance NN cord-349011-kxhpdvri 80 13 of of IN cord-349011-kxhpdvri 80 14 your -PRON- PRP$ cord-349011-kxhpdvri 80 15 research research NN cord-349011-kxhpdvri 80 16 , , , cord-349011-kxhpdvri 80 17 articulation articulation NN cord-349011-kxhpdvri 80 18 of of IN cord-349011-kxhpdvri 80 19 a a DT cord-349011-kxhpdvri 80 20 clear clear JJ cord-349011-kxhpdvri 80 21 take take VB cord-349011-kxhpdvri 80 22 - - HYPH cord-349011-kxhpdvri 80 23 home home NN cord-349011-kxhpdvri 80 24 message message NN cord-349011-kxhpdvri 80 25 , , , cord-349011-kxhpdvri 80 26 and and CC cord-349011-kxhpdvri 80 27 considering consider VBG cord-349011-kxhpdvri 80 28 the the DT cord-349011-kxhpdvri 80 29 audience audience NN cord-349011-kxhpdvri 80 30 for for IN cord-349011-kxhpdvri 80 31 your -PRON- PRP$ cord-349011-kxhpdvri 80 32 research research NN cord-349011-kxhpdvri 80 33 . . . cord-349011-kxhpdvri 81 1 Due due JJ cord-349011-kxhpdvri 81 2 attention attention NN cord-349011-kxhpdvri 81 3 was be VBD cord-349011-kxhpdvri 81 4 paid pay VBN cord-349011-kxhpdvri 81 5 to to IN cord-349011-kxhpdvri 81 6 ethical ethical JJ cord-349011-kxhpdvri 81 7 issues issue NNS cord-349011-kxhpdvri 81 8 in in IN cord-349011-kxhpdvri 81 9 publishing publishing NN cord-349011-kxhpdvri 81 10 , , , cord-349011-kxhpdvri 81 11 and and CC cord-349011-kxhpdvri 81 12 open open JJ cord-349011-kxhpdvri 81 13 - - HYPH cord-349011-kxhpdvri 81 14 access access NN cord-349011-kxhpdvri 81 15 publishing publishing NN cord-349011-kxhpdvri 81 16 was be VBD cord-349011-kxhpdvri 81 17 promoted promote VBN cord-349011-kxhpdvri 81 18 as as IN cord-349011-kxhpdvri 81 19 a a DT cord-349011-kxhpdvri 81 20 mechanism mechanism NN cord-349011-kxhpdvri 81 21 to to TO cord-349011-kxhpdvri 81 22 maximize maximize VB cord-349011-kxhpdvri 81 23 the the DT cord-349011-kxhpdvri 81 24 impact impact NN cord-349011-kxhpdvri 81 25 of of IN cord-349011-kxhpdvri 81 26 research research NN cord-349011-kxhpdvri 81 27 . . . cord-349011-kxhpdvri 82 1 The the DT cord-349011-kxhpdvri 82 2 first first JJ cord-349011-kxhpdvri 82 3 afternoon afternoon NN cord-349011-kxhpdvri 82 4 session session NN cord-349011-kxhpdvri 82 5 focused focus VBN cord-349011-kxhpdvri 82 6 on on IN cord-349011-kxhpdvri 82 7 " " `` cord-349011-kxhpdvri 82 8 Viruses virus NNS cord-349011-kxhpdvri 82 9 of of IN cord-349011-kxhpdvri 82 10 Microbes Microbes NNPS cord-349011-kxhpdvri 82 11 " " '' cord-349011-kxhpdvri 82 12 was be VBD cord-349011-kxhpdvri 82 13 chaired chair VBN cord-349011-kxhpdvri 82 14 by by IN cord-349011-kxhpdvri 82 15 Dr. Dr. NNP cord-349011-kxhpdvri 82 16 Karen Karen NNP cord-349011-kxhpdvri 82 17 Maxwell Maxwell NNP cord-349011-kxhpdvri 82 18 ( ( -LRB- cord-349011-kxhpdvri 82 19 University University NNP cord-349011-kxhpdvri 82 20 of of IN cord-349011-kxhpdvri 82 21 Toronto Toronto NNP cord-349011-kxhpdvri 82 22 ) ) -RRB- cord-349011-kxhpdvri 82 23 . . . cord-349011-kxhpdvri 83 1 In in IN cord-349011-kxhpdvri 83 2 the the DT cord-349011-kxhpdvri 83 3 first first JJ cord-349011-kxhpdvri 83 4 talk talk NN cord-349011-kxhpdvri 83 5 of of IN cord-349011-kxhpdvri 83 6 the the DT cord-349011-kxhpdvri 83 7 session session NN cord-349011-kxhpdvri 83 8 , , , cord-349011-kxhpdvri 83 9 Dr. Dr. NNP cord-349011-kxhpdvri 83 10 Maxwell Maxwell NNP cord-349011-kxhpdvri 83 11 described describe VBD cord-349011-kxhpdvri 83 12 a a DT cord-349011-kxhpdvri 83 13 new new JJ cord-349011-kxhpdvri 83 14 host host NN cord-349011-kxhpdvri 83 15 defense defense NN cord-349011-kxhpdvri 83 16 mechanism mechanism NN cord-349011-kxhpdvri 83 17 against against IN cord-349011-kxhpdvri 83 18 viral viral JJ cord-349011-kxhpdvri 83 19 infection infection NN cord-349011-kxhpdvri 83 20 . . . cord-349011-kxhpdvri 84 1 Bacteria Bacteria NNS cord-349011-kxhpdvri 84 2 have have VBP cord-349011-kxhpdvri 84 3 long long RB cord-349011-kxhpdvri 84 4 been be VBN cord-349011-kxhpdvri 84 5 known know VBN cord-349011-kxhpdvri 84 6 to to TO cord-349011-kxhpdvri 84 7 defend defend VB cord-349011-kxhpdvri 84 8 against against IN cord-349011-kxhpdvri 84 9 bacteriophage bacteriophage NN cord-349011-kxhpdvri 84 10 infection infection NN cord-349011-kxhpdvri 84 11 using use VBG cord-349011-kxhpdvri 84 12 restriction restriction NN cord-349011-kxhpdvri 84 13 endonucleases endonuclease NNS cord-349011-kxhpdvri 84 14 , , , cord-349011-kxhpdvri 84 15 cell cell NN cord-349011-kxhpdvri 84 16 surface surface NN cord-349011-kxhpdvri 84 17 modifications modification NNS cord-349011-kxhpdvri 84 18 and and CC cord-349011-kxhpdvri 84 19 abortive abortive JJ cord-349011-kxhpdvri 84 20 infection infection NN cord-349011-kxhpdvri 84 21 systems system NNS cord-349011-kxhpdvri 84 22 , , , cord-349011-kxhpdvri 84 23 and and CC cord-349011-kxhpdvri 84 24 the the DT cord-349011-kxhpdvri 84 25 past past JJ cord-349011-kxhpdvri 84 26 15 15 CD cord-349011-kxhpdvri 84 27 years year NNS cord-349011-kxhpdvri 84 28 have have VBP cord-349011-kxhpdvri 84 29 seen see VBN cord-349011-kxhpdvri 84 30 a a DT cord-349011-kxhpdvri 84 31 rapid rapid JJ cord-349011-kxhpdvri 84 32 expansion expansion NN cord-349011-kxhpdvri 84 33 of of IN cord-349011-kxhpdvri 84 34 our -PRON- PRP$ cord-349011-kxhpdvri 84 35 understanding understanding NN cord-349011-kxhpdvri 84 36 of of IN cord-349011-kxhpdvri 84 37 diverse diverse JJ cord-349011-kxhpdvri 84 38 CRISPR CRISPR NNP cord-349011-kxhpdvri 84 39 - - HYPH cord-349011-kxhpdvri 84 40 Cas Cas NNP cord-349011-kxhpdvri 84 41 systems system NNS cord-349011-kxhpdvri 84 42 that that WDT cord-349011-kxhpdvri 84 43 provide provide VBP cord-349011-kxhpdvri 84 44 a a DT cord-349011-kxhpdvri 84 45 form form NN cord-349011-kxhpdvri 84 46 of of IN cord-349011-kxhpdvri 84 47 adaptive adaptive JJ cord-349011-kxhpdvri 84 48 immune immune JJ cord-349011-kxhpdvri 84 49 memory memory NN cord-349011-kxhpdvri 84 50 for for IN cord-349011-kxhpdvri 84 51 bacteria bacteria NNS cord-349011-kxhpdvri 84 52 [ [ -LRB- cord-349011-kxhpdvri 84 53 24 24 CD cord-349011-kxhpdvri 84 54 ] ] -RRB- cord-349011-kxhpdvri 84 55 . . . cord-349011-kxhpdvri 85 1 All all PDT cord-349011-kxhpdvri 85 2 these these DT cord-349011-kxhpdvri 85 3 systems system NNS cord-349011-kxhpdvri 85 4 rely rely VBP cord-349011-kxhpdvri 85 5 on on IN cord-349011-kxhpdvri 85 6 bacterial bacterial JJ cord-349011-kxhpdvri 85 7 proteins protein NNS cord-349011-kxhpdvri 85 8 or or CC cord-349011-kxhpdvri 85 9 protein protein NN cord-349011-kxhpdvri 85 10 / / SYM cord-349011-kxhpdvri 85 11 RNA RNA NNP cord-349011-kxhpdvri 85 12 complexes complex NNS cord-349011-kxhpdvri 85 13 to to TO cord-349011-kxhpdvri 85 14 execute execute VB cord-349011-kxhpdvri 85 15 antiviral antiviral JJ cord-349011-kxhpdvri 85 16 defense defense NN cord-349011-kxhpdvri 85 17 . . . cord-349011-kxhpdvri 86 1 Dr. Dr. NNP cord-349011-kxhpdvri 86 2 Maxwell Maxwell NNP cord-349011-kxhpdvri 86 3 described describe VBD cord-349011-kxhpdvri 86 4 the the DT cord-349011-kxhpdvri 86 5 discovery discovery NN cord-349011-kxhpdvri 86 6 of of IN cord-349011-kxhpdvri 86 7 a a DT cord-349011-kxhpdvri 86 8 new new JJ cord-349011-kxhpdvri 86 9 chemical chemical NN cord-349011-kxhpdvri 86 10 defense defense NN cord-349011-kxhpdvri 86 11 against against IN cord-349011-kxhpdvri 86 12 phage phage NN cord-349011-kxhpdvri 86 13 infection infection NN cord-349011-kxhpdvri 86 14 of of IN cord-349011-kxhpdvri 86 15 the the DT cord-349011-kxhpdvri 86 16 soil soil NN cord-349011-kxhpdvri 86 17 - - HYPH cord-349011-kxhpdvri 86 18 dwelling dwell VBG cord-349011-kxhpdvri 86 19 bacteria bacteria NNS cord-349011-kxhpdvri 86 20 Streptomyces Streptomyces NNP cord-349011-kxhpdvri 86 21 . . . cord-349011-kxhpdvri 87 1 These these DT cord-349011-kxhpdvri 87 2 molecules molecule NNS cord-349011-kxhpdvri 87 3 include include VBP cord-349011-kxhpdvri 87 4 anthracyclines anthracycline NNS cord-349011-kxhpdvri 87 5 that that WDT cord-349011-kxhpdvri 87 6 act act VBP cord-349011-kxhpdvri 87 7 as as IN cord-349011-kxhpdvri 87 8 DNA dna NN cord-349011-kxhpdvri 87 9 - - HYPH cord-349011-kxhpdvri 87 10 intercalating intercalate VBG cord-349011-kxhpdvri 87 11 agents agent NNS cord-349011-kxhpdvri 87 12 that that WDT cord-349011-kxhpdvri 87 13 disrupt disrupt VBP cord-349011-kxhpdvri 87 14 the the DT cord-349011-kxhpdvri 87 15 early early JJ cord-349011-kxhpdvri 87 16 stages stage NNS cord-349011-kxhpdvri 87 17 of of IN cord-349011-kxhpdvri 87 18 infection infection NN cord-349011-kxhpdvri 87 19 by by IN cord-349011-kxhpdvri 87 20 phages phage NNS cord-349011-kxhpdvri 87 21 with with IN cord-349011-kxhpdvri 87 22 DNA dna NN cord-349011-kxhpdvri 87 23 genomes genome NNS cord-349011-kxhpdvri 87 24 , , , cord-349011-kxhpdvri 87 25 perhaps perhaps RB cord-349011-kxhpdvri 87 26 by by IN cord-349011-kxhpdvri 87 27 blocking block VBG cord-349011-kxhpdvri 87 28 circularization circularization NN cord-349011-kxhpdvri 87 29 of of IN cord-349011-kxhpdvri 87 30 the the DT cord-349011-kxhpdvri 87 31 incoming incoming JJ cord-349011-kxhpdvri 87 32 linear linear JJ cord-349011-kxhpdvri 87 33 DNA DNA NNP cord-349011-kxhpdvri 87 34 [ [ -LRB- cord-349011-kxhpdvri 87 35 25 25 CD cord-349011-kxhpdvri 87 36 ] ] -RRB- cord-349011-kxhpdvri 87 37 . . . cord-349011-kxhpdvri 88 1 Dr. Dr. NNP cord-349011-kxhpdvri 88 2 Maxwell Maxwell NNP cord-349011-kxhpdvri 88 3 showed show VBD cord-349011-kxhpdvri 88 4 that that IN cord-349011-kxhpdvri 88 5 Streptomyces Streptomyces NNP cord-349011-kxhpdvri 88 6 bacteria bacteria NNS cord-349011-kxhpdvri 88 7 can can MD cord-349011-kxhpdvri 88 8 secrete secrete VB cord-349011-kxhpdvri 88 9 anthracyclines anthracycline NNS cord-349011-kxhpdvri 88 10 into into IN cord-349011-kxhpdvri 88 11 the the DT cord-349011-kxhpdvri 88 12 extracellular extracellular JJ cord-349011-kxhpdvri 88 13 environment environment NN cord-349011-kxhpdvri 88 14 , , , cord-349011-kxhpdvri 88 15 which which WDT cord-349011-kxhpdvri 88 16 are be VBP cord-349011-kxhpdvri 88 17 then then RB cord-349011-kxhpdvri 88 18 taken take VBN cord-349011-kxhpdvri 88 19 up up RP cord-349011-kxhpdvri 88 20 by by IN cord-349011-kxhpdvri 88 21 neighboring neighbor VBG cord-349011-kxhpdvri 88 22 cells cell NNS cord-349011-kxhpdvri 88 23 to to TO cord-349011-kxhpdvri 88 24 block block VB cord-349011-kxhpdvri 88 25 viral viral JJ cord-349011-kxhpdvri 88 26 infection infection NN cord-349011-kxhpdvri 88 27 . . . cord-349011-kxhpdvri 89 1 In in IN cord-349011-kxhpdvri 89 2 this this DT cord-349011-kxhpdvri 89 3 way way NN cord-349011-kxhpdvri 89 4 , , , cord-349011-kxhpdvri 89 5 these these DT cord-349011-kxhpdvri 89 6 chemicals chemical NNS cord-349011-kxhpdvri 89 7 act act VBP cord-349011-kxhpdvri 89 8 as as IN cord-349011-kxhpdvri 89 9 broad broad JJ cord-349011-kxhpdvri 89 10 - - HYPH cord-349011-kxhpdvri 89 11 spectrum spectrum NN cord-349011-kxhpdvri 89 12 antivirals antiviral NNS cord-349011-kxhpdvri 89 13 that that WDT cord-349011-kxhpdvri 89 14 can can MD cord-349011-kxhpdvri 89 15 protect protect VB cord-349011-kxhpdvri 89 16 and and CC cord-349011-kxhpdvri 89 17 influence influence VB cord-349011-kxhpdvri 89 18 the the DT cord-349011-kxhpdvri 89 19 evolution evolution NN cord-349011-kxhpdvri 89 20 of of IN cord-349011-kxhpdvri 89 21 bacterial bacterial JJ cord-349011-kxhpdvri 89 22 communities community NNS cord-349011-kxhpdvri 89 23 . . . cord-349011-kxhpdvri 90 1 Fecal fecal JJ cord-349011-kxhpdvri 90 2 microbiota microbiota NN cord-349011-kxhpdvri 90 3 transplants transplant NNS cord-349011-kxhpdvri 90 4 ( ( -LRB- cord-349011-kxhpdvri 90 5 FMTs fmt NNS cord-349011-kxhpdvri 90 6 ) ) -RRB- cord-349011-kxhpdvri 90 7 are be VBP cord-349011-kxhpdvri 90 8 increasingly increasingly RB cord-349011-kxhpdvri 90 9 used use VBN cord-349011-kxhpdvri 90 10 to to TO cord-349011-kxhpdvri 90 11 treat treat VB cord-349011-kxhpdvri 90 12 human human JJ cord-349011-kxhpdvri 90 13 intestinal intestinal JJ cord-349011-kxhpdvri 90 14 diseases disease NNS cord-349011-kxhpdvri 90 15 including include VBG cord-349011-kxhpdvri 90 16 ulcerative ulcerative JJ cord-349011-kxhpdvri 90 17 colitis colitis NN cord-349011-kxhpdvri 90 18 [ [ -LRB- cord-349011-kxhpdvri 90 19 26 26 CD cord-349011-kxhpdvri 90 20 ] ] -RRB- cord-349011-kxhpdvri 90 21 and and CC cord-349011-kxhpdvri 90 22 antibiotic antibiotic JJ cord-349011-kxhpdvri 90 23 - - HYPH cord-349011-kxhpdvri 90 24 resistant resistant JJ cord-349011-kxhpdvri 90 25 Clostridium clostridium NN cord-349011-kxhpdvri 90 26 difficile difficile NN cord-349011-kxhpdvri 90 27 infections infection NNS cord-349011-kxhpdvri 90 28 [ [ -LRB- cord-349011-kxhpdvri 90 29 27 27 CD cord-349011-kxhpdvri 90 30 ] ] -RRB- cord-349011-kxhpdvri 90 31 . . . cord-349011-kxhpdvri 91 1 However however RB cord-349011-kxhpdvri 91 2 , , , cord-349011-kxhpdvri 91 3 documenting document VBG cord-349011-kxhpdvri 91 4 successful successful JJ cord-349011-kxhpdvri 91 5 transplant transplant NN cord-349011-kxhpdvri 91 6 of of IN cord-349011-kxhpdvri 91 7 gut gut NN cord-349011-kxhpdvri 91 8 microbiota microbiota NN cord-349011-kxhpdvri 91 9 in in IN cord-349011-kxhpdvri 91 10 FMT fmt NN cord-349011-kxhpdvri 91 11 recipients recipient NNS cord-349011-kxhpdvri 91 12 remains remain VBZ cord-349011-kxhpdvri 91 13 challenging challenge VBG cord-349011-kxhpdvri 91 14 . . . cord-349011-kxhpdvri 92 1 FMT FMT NNP cord-349011-kxhpdvri 92 2 inevitably inevitably RB cord-349011-kxhpdvri 92 3 transfer transfer VBP cord-349011-kxhpdvri 92 4 bacteriophages bacteriophage NNS cord-349011-kxhpdvri 92 5 as as RB cord-349011-kxhpdvri 92 6 well well RB cord-349011-kxhpdvri 92 7 [ [ -LRB- cord-349011-kxhpdvri 92 8 28 28 CD cord-349011-kxhpdvri 92 9 ] ] -RRB- cord-349011-kxhpdvri 92 10 , , , cord-349011-kxhpdvri 92 11 but but CC cord-349011-kxhpdvri 92 12 little little JJ cord-349011-kxhpdvri 92 13 is be VBZ cord-349011-kxhpdvri 92 14 known know VBN cord-349011-kxhpdvri 92 15 about about IN cord-349011-kxhpdvri 92 16 how how WRB cord-349011-kxhpdvri 92 17 transferred transfer VBN cord-349011-kxhpdvri 92 18 phage phage NN cord-349011-kxhpdvri 92 19 affect affect VBP cord-349011-kxhpdvri 92 20 the the DT cord-349011-kxhpdvri 92 21 recipient recipient NN cord-349011-kxhpdvri 92 22 microbiome microbiome NN cord-349011-kxhpdvri 92 23 . . . cord-349011-kxhpdvri 93 1 Dr. Dr. NNP cord-349011-kxhpdvri 93 2 Alexander Alexander NNP cord-349011-kxhpdvri 93 3 Hynes Hynes NNP cord-349011-kxhpdvri 93 4 ( ( -LRB- cord-349011-kxhpdvri 93 5 McMaster McMaster NNP cord-349011-kxhpdvri 93 6 University University NNP cord-349011-kxhpdvri 93 7 ) ) -RRB- cord-349011-kxhpdvri 93 8 described describe VBD cord-349011-kxhpdvri 93 9 studies study NNS cord-349011-kxhpdvri 93 10 designed design VBN cord-349011-kxhpdvri 93 11 to to TO cord-349011-kxhpdvri 93 12 address address VB cord-349011-kxhpdvri 93 13 this this DT cord-349011-kxhpdvri 93 14 directly directly RB cord-349011-kxhpdvri 93 15 by by IN cord-349011-kxhpdvri 93 16 studying study VBG cord-349011-kxhpdvri 93 17 crAssphage crassphage NN cord-349011-kxhpdvri 93 18 , , , cord-349011-kxhpdvri 93 19 the the DT cord-349011-kxhpdvri 93 20 most most RBS cord-349011-kxhpdvri 93 21 abundant abundant JJ cord-349011-kxhpdvri 93 22 phage phage NN cord-349011-kxhpdvri 93 23 in in IN cord-349011-kxhpdvri 93 24 humans human NNS cord-349011-kxhpdvri 93 25 . . . cord-349011-kxhpdvri 94 1 crAssphage crAssphage NNP cord-349011-kxhpdvri 94 2 was be VBD cord-349011-kxhpdvri 94 3 recently recently RB cord-349011-kxhpdvri 94 4 discovered discover VBN cord-349011-kxhpdvri 94 5 by by IN cord-349011-kxhpdvri 94 6 metagenomic metagenomic NNP cord-349011-kxhpdvri 94 7 sequencing sequencing NNP cord-349011-kxhpdvri 94 8 [ [ -LRB- cord-349011-kxhpdvri 94 9 29 29 CD cord-349011-kxhpdvri 94 10 ] ] -RRB- cord-349011-kxhpdvri 94 11 but but CC cord-349011-kxhpdvri 94 12 its -PRON- PRP$ cord-349011-kxhpdvri 94 13 natural natural JJ cord-349011-kxhpdvri 94 14 bacterial bacterial JJ cord-349011-kxhpdvri 94 15 host host NN cord-349011-kxhpdvri 94 16 had have VBD cord-349011-kxhpdvri 94 17 not not RB cord-349011-kxhpdvri 94 18 yet yet RB cord-349011-kxhpdvri 94 19 been be VBN cord-349011-kxhpdvri 94 20 identified identify VBN cord-349011-kxhpdvri 94 21 . . . cord-349011-kxhpdvri 95 1 Using use VBG cord-349011-kxhpdvri 95 2 PCR PCR NNP cord-349011-kxhpdvri 95 3 and and CC cord-349011-kxhpdvri 95 4 metagenomic metagenomic NNP cord-349011-kxhpdvri 95 5 analysis analysis NN cord-349011-kxhpdvri 95 6 , , , cord-349011-kxhpdvri 95 7 Dr. Dr. NNP cord-349011-kxhpdvri 95 8 Hynes Hynes NNP cord-349011-kxhpdvri 95 9 's 's POS cord-349011-kxhpdvri 95 10 group group NN cord-349011-kxhpdvri 95 11 tracked track VBD cord-349011-kxhpdvri 95 12 crAssphage crassphage NN cord-349011-kxhpdvri 95 13 transfer transfer NN cord-349011-kxhpdvri 95 14 from from IN cord-349011-kxhpdvri 95 15 phage phage NN cord-349011-kxhpdvri 95 16 - - HYPH cord-349011-kxhpdvri 95 17 positive positive JJ cord-349011-kxhpdvri 95 18 human human JJ cord-349011-kxhpdvri 95 19 donors donor NNS cord-349011-kxhpdvri 95 20 to to IN cord-349011-kxhpdvri 95 21 human human JJ cord-349011-kxhpdvri 95 22 FMT fmt NN cord-349011-kxhpdvri 95 23 recipients recipient NNS cord-349011-kxhpdvri 95 24 or or CC cord-349011-kxhpdvri 95 25 germ germ NN cord-349011-kxhpdvri 95 26 - - HYPH cord-349011-kxhpdvri 95 27 free free JJ cord-349011-kxhpdvri 95 28 mice mouse NNS cord-349011-kxhpdvri 95 29 . . . cord-349011-kxhpdvri 96 1 Studying study VBG cord-349011-kxhpdvri 96 2 the the DT cord-349011-kxhpdvri 96 3 bacteria bacteria NNS cord-349011-kxhpdvri 96 4 transferred transfer VBN cord-349011-kxhpdvri 96 5 along along RB cord-349011-kxhpdvri 96 6 with with IN cord-349011-kxhpdvri 96 7 the the DT cord-349011-kxhpdvri 96 8 crAssphage crassphage NN cord-349011-kxhpdvri 96 9 into into IN cord-349011-kxhpdvri 96 10 naïve naïve JJ cord-349011-kxhpdvri 96 11 recipients recipient NNS cord-349011-kxhpdvri 96 12 may may MD cord-349011-kxhpdvri 96 13 provide provide VB cord-349011-kxhpdvri 96 14 opportunities opportunity NNS cord-349011-kxhpdvri 96 15 to to TO cord-349011-kxhpdvri 96 16 discover discover VB cord-349011-kxhpdvri 96 17 the the DT cord-349011-kxhpdvri 96 18 elusive elusive JJ cord-349011-kxhpdvri 96 19 crAssphage crAssphage NNP cord-349011-kxhpdvri 96 20 host host NN cord-349011-kxhpdvri 96 21 . . . cord-349011-kxhpdvri 97 1 The the DT cord-349011-kxhpdvri 97 2 " " `` cord-349011-kxhpdvri 97 3 Viruses virus NNS cord-349011-kxhpdvri 97 4 of of IN cord-349011-kxhpdvri 97 5 Microbes Microbes NNPS cord-349011-kxhpdvri 97 6 " " '' cord-349011-kxhpdvri 97 7 session session NN cord-349011-kxhpdvri 97 8 also also RB cord-349011-kxhpdvri 97 9 included include VBD cord-349011-kxhpdvri 97 10 presentations presentation NNS cord-349011-kxhpdvri 97 11 from from IN cord-349011-kxhpdvri 97 12 the the DT cord-349011-kxhpdvri 97 13 following follow VBG cord-349011-kxhpdvri 97 14 trainees trainee NNS cord-349011-kxhpdvri 97 15 : : : cord-349011-kxhpdvri 97 16 Casey Casey NNP cord-349011-kxhpdvri 97 17 Jones Jones NNP cord-349011-kxhpdvri 97 18 ( ( -LRB- cord-349011-kxhpdvri 97 19 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 97 20 University University NNP cord-349011-kxhpdvri 97 21 ) ) -RRB- cord-349011-kxhpdvri 97 22 who who WP cord-349011-kxhpdvri 97 23 reported report VBD cord-349011-kxhpdvri 97 24 on on IN cord-349011-kxhpdvri 97 25 the the DT cord-349011-kxhpdvri 97 26 state state NN cord-349011-kxhpdvri 97 27 of of IN cord-349011-kxhpdvri 97 28 the the DT cord-349011-kxhpdvri 97 29 gut gut NN cord-349011-kxhpdvri 97 30 virome virome NN cord-349011-kxhpdvri 97 31 in in IN cord-349011-kxhpdvri 97 32 pediatric pediatric JJ cord-349011-kxhpdvri 97 33 Crohn Crohn NNP cord-349011-kxhpdvri 97 34 's 's POS cord-349011-kxhpdvri 97 35 Disease Disease NNP cord-349011-kxhpdvri 97 36 [ [ -LRB- cord-349011-kxhpdvri 97 37 30 30 CD cord-349011-kxhpdvri 97 38 ] ] -RRB- cord-349011-kxhpdvri 97 39 , , , cord-349011-kxhpdvri 97 40 Jaclyn Jaclyn NNP cord-349011-kxhpdvri 97 41 McCutcheon McCutcheon NNP cord-349011-kxhpdvri 97 42 ( ( -LRB- cord-349011-kxhpdvri 97 43 University University NNP cord-349011-kxhpdvri 97 44 of of IN cord-349011-kxhpdvri 97 45 Alberta Alberta NNP cord-349011-kxhpdvri 97 46 ) ) -RRB- cord-349011-kxhpdvri 97 47 who who WP cord-349011-kxhpdvri 97 48 presented present VBD cord-349011-kxhpdvri 97 49 her -PRON- PRP$ cord-349011-kxhpdvri 97 50 discovery discovery NN cord-349011-kxhpdvri 97 51 of of IN cord-349011-kxhpdvri 97 52 type type NN cord-349011-kxhpdvri 97 53 IV IV NNP cord-349011-kxhpdvri 97 54 pili pili NNP cord-349011-kxhpdvri 97 55 as as IN cord-349011-kxhpdvri 97 56 receptors receptor NNS cord-349011-kxhpdvri 97 57 for for IN cord-349011-kxhpdvri 97 58 bacteriophages bacteriophage NNS cord-349011-kxhpdvri 97 59 on on IN cord-349011-kxhpdvri 97 60 Stenotrophomonas Stenotrophomonas NNP cord-349011-kxhpdvri 97 61 maltophilia maltophilia NNP cord-349011-kxhpdvri 97 62 [ [ -LRB- cord-349011-kxhpdvri 97 63 31 31 CD cord-349011-kxhpdvri 97 64 ] ] -RRB- cord-349011-kxhpdvri 97 65 , , , cord-349011-kxhpdvri 97 66 and and CC cord-349011-kxhpdvri 97 67 Nikhil Nikhil NNP cord-349011-kxhpdvri 97 68 George George NNP cord-349011-kxhpdvri 97 69 ( ( -LRB- cord-349011-kxhpdvri 97 70 University University NNP cord-349011-kxhpdvri 97 71 of of IN cord-349011-kxhpdvri 97 72 Waterloo Waterloo NNP cord-349011-kxhpdvri 97 73 ) ) -RRB- cord-349011-kxhpdvri 97 74 who who WP cord-349011-kxhpdvri 97 75 presented present VBD cord-349011-kxhpdvri 97 76 his -PRON- PRP$ cord-349011-kxhpdvri 97 77 studies study NNS cord-349011-kxhpdvri 97 78 of of IN cord-349011-kxhpdvri 97 79 CRISPR CRISPR NNP cord-349011-kxhpdvri 97 80 - - HYPH cord-349011-kxhpdvri 97 81 Cas Cas NNP cord-349011-kxhpdvri 97 82 - - HYPH cord-349011-kxhpdvri 97 83 based base VBN cord-349011-kxhpdvri 97 84 warfare warfare NN cord-349011-kxhpdvri 97 85 between between IN cord-349011-kxhpdvri 97 86 phage phage NN cord-349011-kxhpdvri 97 87 and and CC cord-349011-kxhpdvri 97 88 bacteria bacteria NNS cord-349011-kxhpdvri 97 89 in in IN cord-349011-kxhpdvri 97 90 a a DT cord-349011-kxhpdvri 97 91 municipal municipal JJ cord-349011-kxhpdvri 97 92 landfill landfill NN cord-349011-kxhpdvri 97 93 site site NN cord-349011-kxhpdvri 97 94 . . . cord-349011-kxhpdvri 98 1 Following follow VBG cord-349011-kxhpdvri 98 2 an an DT cord-349011-kxhpdvri 98 3 afternoon afternoon NN cord-349011-kxhpdvri 98 4 break break NN cord-349011-kxhpdvri 98 5 , , , cord-349011-kxhpdvri 98 6 Dr. Dr. NNP cord-349011-kxhpdvri 98 7 Matthias Matthias NNP cord-349011-kxhpdvri 98 8 Götte Götte NNP cord-349011-kxhpdvri 98 9 ( ( -LRB- cord-349011-kxhpdvri 98 10 University University NNP cord-349011-kxhpdvri 98 11 of of IN cord-349011-kxhpdvri 98 12 Alberta Alberta NNP cord-349011-kxhpdvri 98 13 ) ) -RRB- cord-349011-kxhpdvri 98 14 chaired chair VBD cord-349011-kxhpdvri 98 15 a a DT cord-349011-kxhpdvri 98 16 session session NN cord-349011-kxhpdvri 98 17 on on IN cord-349011-kxhpdvri 98 18 " " `` cord-349011-kxhpdvri 98 19 Antivirals Antivirals NNPS cord-349011-kxhpdvri 98 20 and and CC cord-349011-kxhpdvri 98 21 Vaccines Vaccines NNPS cord-349011-kxhpdvri 98 22 " " '' cord-349011-kxhpdvri 98 23 . . . cord-349011-kxhpdvri 99 1 This this DT cord-349011-kxhpdvri 99 2 session session NN cord-349011-kxhpdvri 99 3 was be VBD cord-349011-kxhpdvri 99 4 kicked kick VBN cord-349011-kxhpdvri 99 5 off off RP cord-349011-kxhpdvri 99 6 in in IN cord-349011-kxhpdvri 99 7 an an DT cord-349011-kxhpdvri 99 8 electric electric JJ cord-349011-kxhpdvri 99 9 fashion fashion NN cord-349011-kxhpdvri 99 10 by by IN cord-349011-kxhpdvri 99 11 four four CD cord-349011-kxhpdvri 99 12 3-minute 3-minute CD cord-349011-kxhpdvri 99 13 thesis thesis NN cord-349011-kxhpdvri 99 14 - - HYPH cord-349011-kxhpdvri 99 15 style style NN cord-349011-kxhpdvri 99 16 presentations presentation NNS cord-349011-kxhpdvri 99 17 from from IN cord-349011-kxhpdvri 99 18 trainees trainee NNS cord-349011-kxhpdvri 99 19 . . . cord-349011-kxhpdvri 100 1 Using use VBG cord-349011-kxhpdvri 100 2 only only RB cord-349011-kxhpdvri 100 3 a a DT cord-349011-kxhpdvri 100 4 single single JJ cord-349011-kxhpdvri 100 5 slide slide NN cord-349011-kxhpdvri 100 6 , , , cord-349011-kxhpdvri 100 7 Ali Ali NNP cord-349011-kxhpdvri 100 8 Zhang Zhang NNP cord-349011-kxhpdvri 100 9 ( ( -LRB- cord-349011-kxhpdvri 100 10 McMaster McMaster NNP cord-349011-kxhpdvri 100 11 University University NNP cord-349011-kxhpdvri 100 12 ) ) -RRB- cord-349011-kxhpdvri 100 13 , , , cord-349011-kxhpdvri 100 14 Briti Briti NNP cord-349011-kxhpdvri 100 15 Saha Saha NNP cord-349011-kxhpdvri 100 16 ( ( -LRB- cord-349011-kxhpdvri 100 17 University University NNP cord-349011-kxhpdvri 100 18 of of IN cord-349011-kxhpdvri 100 19 Ottawa Ottawa NNP cord-349011-kxhpdvri 100 20 ) ) -RRB- cord-349011-kxhpdvri 100 21 and and CC cord-349011-kxhpdvri 100 22 Mariel Mariel NNP cord-349011-kxhpdvri 100 23 Kleer Kleer NNP cord-349011-kxhpdvri 100 24 and and CC cord-349011-kxhpdvri 100 25 Andrea Andrea NNP cord-349011-kxhpdvri 100 26 Monjo Monjo NNP cord-349011-kxhpdvri 100 27 from from IN cord-349011-kxhpdvri 100 28 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 100 29 University University NNP cord-349011-kxhpdvri 100 30 clearly clearly RB cord-349011-kxhpdvri 100 31 and and CC cord-349011-kxhpdvri 100 32 concisely concisely RB cord-349011-kxhpdvri 100 33 presented present VBD cord-349011-kxhpdvri 100 34 their -PRON- PRP$ cord-349011-kxhpdvri 100 35 respective respective JJ cord-349011-kxhpdvri 100 36 research research NN cord-349011-kxhpdvri 100 37 projects project NNS cord-349011-kxhpdvri 100 38 . . . cord-349011-kxhpdvri 101 1 The the DT cord-349011-kxhpdvri 101 2 general general JJ cord-349011-kxhpdvri 101 3 consensus consensus NN cord-349011-kxhpdvri 101 4 was be VBD cord-349011-kxhpdvri 101 5 that that IN cord-349011-kxhpdvri 101 6 future future JJ cord-349011-kxhpdvri 101 7 CSV csv NN cord-349011-kxhpdvri 101 8 symposia symposium NNS cord-349011-kxhpdvri 101 9 should should MD cord-349011-kxhpdvri 101 10 feature feature VB cord-349011-kxhpdvri 101 11 more more JJR cord-349011-kxhpdvri 101 12 of of IN cord-349011-kxhpdvri 101 13 these these DT cord-349011-kxhpdvri 101 14 " " `` cord-349011-kxhpdvri 101 15 flash flash NN cord-349011-kxhpdvri 101 16 " " '' cord-349011-kxhpdvri 101 17 talks talk NNS cord-349011-kxhpdvri 101 18 from from IN cord-349011-kxhpdvri 101 19 trainees trainee NNS cord-349011-kxhpdvri 101 20 ( ( -LRB- cord-349011-kxhpdvri 101 21 and and CC cord-349011-kxhpdvri 101 22 maybe maybe RB cord-349011-kxhpdvri 101 23 the the DT cord-349011-kxhpdvri 101 24 PIs pi NNS cord-349011-kxhpdvri 101 25 should should MD cord-349011-kxhpdvri 101 26 be be VB cord-349011-kxhpdvri 101 27 challenged challenge VBN cord-349011-kxhpdvri 101 28 to to TO cord-349011-kxhpdvri 101 29 do do VB cord-349011-kxhpdvri 101 30 the the DT cord-349011-kxhpdvri 101 31 same same JJ cord-349011-kxhpdvri 101 32 ! ! . cord-349011-kxhpdvri 101 33 ) ) -RRB- cord-349011-kxhpdvri 101 34 . . . cord-349011-kxhpdvri 102 1 This this DT cord-349011-kxhpdvri 102 2 was be VBD cord-349011-kxhpdvri 102 3 followed follow VBN cord-349011-kxhpdvri 102 4 by by IN cord-349011-kxhpdvri 102 5 a a DT cord-349011-kxhpdvri 102 6 panel panel NN cord-349011-kxhpdvri 102 7 discussion discussion NN cord-349011-kxhpdvri 102 8 about about IN cord-349011-kxhpdvri 102 9 the the DT cord-349011-kxhpdvri 102 10 future future NN cord-349011-kxhpdvri 102 11 of of IN cord-349011-kxhpdvri 102 12 antiviral antiviral JJ cord-349011-kxhpdvri 102 13 and and CC cord-349011-kxhpdvri 102 14 vaccine vaccine NN cord-349011-kxhpdvri 102 15 discovery discovery NN cord-349011-kxhpdvri 102 16 and and CC cord-349011-kxhpdvri 102 17 development development NN cord-349011-kxhpdvri 102 18 , , , cord-349011-kxhpdvri 102 19 chaired chair VBN cord-349011-kxhpdvri 102 20 by by IN cord-349011-kxhpdvri 102 21 Dr. Dr. NNP cord-349011-kxhpdvri 102 22 Götte Götte NNP cord-349011-kxhpdvri 102 23 and and CC cord-349011-kxhpdvri 102 24 featuring feature VBG cord-349011-kxhpdvri 102 25 panel panel NN cord-349011-kxhpdvri 102 26 members member NNS cord-349011-kxhpdvri 102 27 _SP cord-349011-kxhpdvri 102 28 Following follow VBG cord-349011-kxhpdvri 102 29 the the DT cord-349011-kxhpdvri 102 30 " " `` cord-349011-kxhpdvri 102 31 Antivirals Antivirals NNPS cord-349011-kxhpdvri 102 32 and and CC cord-349011-kxhpdvri 102 33 Vaccines Vaccines NNPS cord-349011-kxhpdvri 102 34 " " '' cord-349011-kxhpdvri 102 35 session session NN cord-349011-kxhpdvri 102 36 , , , cord-349011-kxhpdvri 102 37 everyone everyone NN cord-349011-kxhpdvri 102 38 had have VBD cord-349011-kxhpdvri 102 39 an an DT cord-349011-kxhpdvri 102 40 opportunity opportunity NN cord-349011-kxhpdvri 102 41 to to TO cord-349011-kxhpdvri 102 42 get get VB cord-349011-kxhpdvri 102 43 some some DT cord-349011-kxhpdvri 102 44 fresh fresh JJ cord-349011-kxhpdvri 102 45 air air NN cord-349011-kxhpdvri 102 46 and and CC cord-349011-kxhpdvri 102 47 participate participate VB cord-349011-kxhpdvri 102 48 in in IN cord-349011-kxhpdvri 102 49 a a DT cord-349011-kxhpdvri 102 50 preview preview NN cord-349011-kxhpdvri 102 51 of of IN cord-349011-kxhpdvri 102 52 Halifax Halifax NNP cord-349011-kxhpdvri 102 53 's 's POS cord-349011-kxhpdvri 102 54 first first JJ cord-349011-kxhpdvri 102 55 Soapbox Soapbox NNP cord-349011-kxhpdvri 102 56 Science Science NNP cord-349011-kxhpdvri 102 57 event event NN cord-349011-kxhpdvri 102 58 , , , cord-349011-kxhpdvri 102 59 spearheaded spearhead VBN cord-349011-kxhpdvri 102 60 by by IN cord-349011-kxhpdvri 102 61 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 102 62 University University NNP cord-349011-kxhpdvri 102 63 graduate graduate NN cord-349011-kxhpdvri 102 64 student student NN cord-349011-kxhpdvri 102 65 Emma Emma NNP cord-349011-kxhpdvri 102 66 Finlayson Finlayson NNP cord-349011-kxhpdvri 102 67 - - HYPH cord-349011-kxhpdvri 102 68 Trick Trick NNP cord-349011-kxhpdvri 102 69 . . . cord-349011-kxhpdvri 103 1 Soapbox Soapbox NNP cord-349011-kxhpdvri 103 2 Science Science NNP cord-349011-kxhpdvri 103 3 is be VBZ cord-349011-kxhpdvri 103 4 an an DT cord-349011-kxhpdvri 103 5 international international JJ cord-349011-kxhpdvri 103 6 program program NN cord-349011-kxhpdvri 103 7 that that WDT cord-349011-kxhpdvri 103 8 promotes promote VBZ cord-349011-kxhpdvri 103 9 the the DT cord-349011-kxhpdvri 103 10 creation creation NN cord-349011-kxhpdvri 103 11 of of IN cord-349011-kxhpdvri 103 12 events event NNS cord-349011-kxhpdvri 103 13 that that WDT cord-349011-kxhpdvri 103 14 showcase showcase VBP cord-349011-kxhpdvri 103 15 female female JJ cord-349011-kxhpdvri 103 16 scientists scientist NNS cord-349011-kxhpdvri 103 17 and and CC cord-349011-kxhpdvri 103 18 provides provide VBZ cord-349011-kxhpdvri 103 19 opportunities opportunity NNS cord-349011-kxhpdvri 103 20 for for IN cord-349011-kxhpdvri 103 21 public public JJ cord-349011-kxhpdvri 103 22 outreach outreach NN cord-349011-kxhpdvri 103 23 and and CC cord-349011-kxhpdvri 103 24 science science NN cord-349011-kxhpdvri 103 25 communication communication NN cord-349011-kxhpdvri 103 26 . . . cord-349011-kxhpdvri 104 1 For for IN cord-349011-kxhpdvri 104 2 this this DT cord-349011-kxhpdvri 104 3 preview preview NN cord-349011-kxhpdvri 104 4 , , , cord-349011-kxhpdvri 104 5 Dr. Dr. NNP cord-349011-kxhpdvri 104 6 Maya Maya NNP cord-349011-kxhpdvri 104 7 Shmulevitz Shmulevitz NNP cord-349011-kxhpdvri 104 8 from from IN cord-349011-kxhpdvri 104 9 the the DT cord-349011-kxhpdvri 104 10 University University NNP cord-349011-kxhpdvri 104 11 of of IN cord-349011-kxhpdvri 104 12 Alberta Alberta NNP cord-349011-kxhpdvri 104 13 and and CC cord-349011-kxhpdvri 104 14 Drs Drs NNP cord-349011-kxhpdvri 104 15 . . . cord-349011-kxhpdvri 105 1 Alyson Alyson NNP cord-349011-kxhpdvri 105 2 Kelvin Kelvin NNP cord-349011-kxhpdvri 105 3 and and CC cord-349011-kxhpdvri 105 4 Sarah Sarah NNP cord-349011-kxhpdvri 105 5 Wells Wells NNP cord-349011-kxhpdvri 105 6 and and CC cord-349011-kxhpdvri 105 7 PhD phd NN cord-349011-kxhpdvri 105 8 student student NN cord-349011-kxhpdvri 105 9 Krysta Krysta NNP cord-349011-kxhpdvri 105 10 Coyle Coyle NNP cord-349011-kxhpdvri 105 11 from from IN cord-349011-kxhpdvri 105 12 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 105 13 University University NNP cord-349011-kxhpdvri 105 14 put put VBD cord-349011-kxhpdvri 105 15 on on IN cord-349011-kxhpdvri 105 16 lab lab NN cord-349011-kxhpdvri 105 17 coats coat NNS cord-349011-kxhpdvri 105 18 embossed emboss VBN cord-349011-kxhpdvri 105 19 with with IN cord-349011-kxhpdvri 105 20 the the DT cord-349011-kxhpdvri 105 21 purple purple JJ cord-349011-kxhpdvri 105 22 Soapbox Soapbox NNP cord-349011-kxhpdvri 105 23 Science Science NNP cord-349011-kxhpdvri 105 24 logo logo NN cord-349011-kxhpdvri 105 25 and and CC cord-349011-kxhpdvri 105 26 stood stand VBD cord-349011-kxhpdvri 105 27 on on IN cord-349011-kxhpdvri 105 28 " " `` cord-349011-kxhpdvri 105 29 soapboxes soapbox NNS cord-349011-kxhpdvri 105 30 " " '' cord-349011-kxhpdvri 105 31 built build VBN cord-349011-kxhpdvri 105 32 by by IN cord-349011-kxhpdvri 105 33 volunteer volunteer NN cord-349011-kxhpdvri 105 34 engineers engineer NNS cord-349011-kxhpdvri 105 35 ( ( -LRB- cord-349011-kxhpdvri 105 36 Figure figure NN cord-349011-kxhpdvri 105 37 2 2 CD cord-349011-kxhpdvri 105 38 ) ) -RRB- cord-349011-kxhpdvri 105 39 . . . cord-349011-kxhpdvri 106 1 They -PRON- PRP cord-349011-kxhpdvri 106 2 explained explain VBD cord-349011-kxhpdvri 106 3 their -PRON- PRP$ cord-349011-kxhpdvri 106 4 research research NN cord-349011-kxhpdvri 106 5 using use VBG cord-349011-kxhpdvri 106 6 simple simple JJ cord-349011-kxhpdvri 106 7 props prop NNS cord-349011-kxhpdvri 106 8 to to TO cord-349011-kxhpdvri 106 9 engage engage VB cord-349011-kxhpdvri 106 10 and and CC cord-349011-kxhpdvri 106 11 interact interact VB cord-349011-kxhpdvri 106 12 with with IN cord-349011-kxhpdvri 106 13 the the DT cord-349011-kxhpdvri 106 14 audience audience NN cord-349011-kxhpdvri 106 15 . . . cord-349011-kxhpdvri 107 1 Of of RB cord-349011-kxhpdvri 107 2 course course RB cord-349011-kxhpdvri 107 3 , , , cord-349011-kxhpdvri 107 4 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 107 5 attendees attendee NNS cord-349011-kxhpdvri 107 6 were be VBD cord-349011-kxhpdvri 107 7 exactly exactly RB cord-349011-kxhpdvri 107 8 the the DT cord-349011-kxhpdvri 107 9 opposite opposite NN cord-349011-kxhpdvri 107 10 of of IN cord-349011-kxhpdvri 107 11 the the DT cord-349011-kxhpdvri 107 12 laypeople laypeople NNS cord-349011-kxhpdvri 107 13 that that WDT cord-349011-kxhpdvri 107 14 Soapbox Soapbox NNP cord-349011-kxhpdvri 107 15 Science Science NNP cord-349011-kxhpdvri 107 16 is be VBZ cord-349011-kxhpdvri 107 17 designed design VBN cord-349011-kxhpdvri 107 18 to to TO cord-349011-kxhpdvri 107 19 target target VB cord-349011-kxhpdvri 107 20 , , , cord-349011-kxhpdvri 107 21 but but CC cord-349011-kxhpdvri 107 22 nevertheless nevertheless RB cord-349011-kxhpdvri 107 23 this this DT cord-349011-kxhpdvri 107 24 preview preview NN cord-349011-kxhpdvri 107 25 event event NN cord-349011-kxhpdvri 107 26 provided provide VBD cord-349011-kxhpdvri 107 27 a a DT cord-349011-kxhpdvri 107 28 good good JJ cord-349011-kxhpdvri 107 29 example example NN cord-349011-kxhpdvri 107 30 of of IN cord-349011-kxhpdvri 107 31 how how WRB cord-349011-kxhpdvri 107 32 scientists scientist NNS cord-349011-kxhpdvri 107 33 can can MD cord-349011-kxhpdvri 107 34 reach reach VB cord-349011-kxhpdvri 107 35 out out RP cord-349011-kxhpdvri 107 36 and and CC cord-349011-kxhpdvri 107 37 engage engage VB cord-349011-kxhpdvri 107 38 the the DT cord-349011-kxhpdvri 107 39 public public NN cord-349011-kxhpdvri 107 40 . . . cord-349011-kxhpdvri 108 1 On on IN cord-349011-kxhpdvri 108 2 the the DT cord-349011-kxhpdvri 108 3 Saturday Saturday NNP cord-349011-kxhpdvri 108 4 following follow VBG cord-349011-kxhpdvri 108 5 the the DT cord-349011-kxhpdvri 108 6 symposium symposium NN cord-349011-kxhpdvri 108 7 , , , cord-349011-kxhpdvri 108 8 the the DT cord-349011-kxhpdvri 108 9 actual actual JJ cord-349011-kxhpdvri 108 10 Soapbox Soapbox NNP cord-349011-kxhpdvri 108 11 Science Science NNP cord-349011-kxhpdvri 108 12 event event NN cord-349011-kxhpdvri 108 13 launch launch NN cord-349011-kxhpdvri 108 14 at at IN cord-349011-kxhpdvri 108 15 the the DT cord-349011-kxhpdvri 108 16 Halifax Halifax NNP cord-349011-kxhpdvri 108 17 Seaport Seaport NNP cord-349011-kxhpdvri 108 18 Farmers Farmers NNP cord-349011-kxhpdvri 108 19 ' ' POS cord-349011-kxhpdvri 108 20 Market market NN cord-349011-kxhpdvri 108 21 featured feature VBD cord-349011-kxhpdvri 108 22 twelve twelve CD cord-349011-kxhpdvri 108 23 scientists scientist NNS cord-349011-kxhpdvri 108 24 and and CC cord-349011-kxhpdvri 108 25 attracted attract VBD cord-349011-kxhpdvri 108 26 600 600 CD cord-349011-kxhpdvri 108 27 members member NNS cord-349011-kxhpdvri 108 28 of of IN cord-349011-kxhpdvri 108 29 public public NN cord-349011-kxhpdvri 108 30 over over IN cord-349011-kxhpdvri 108 31 3 3 CD cord-349011-kxhpdvri 108 32 h. h. NN cord-349011-kxhpdvri 108 33 Figure figure NN cord-349011-kxhpdvri 108 34 2 2 CD cord-349011-kxhpdvri 108 35 . . . cord-349011-kxhpdvri 109 1 Soapbox Soapbox NNP cord-349011-kxhpdvri 109 2 Science Science NNP cord-349011-kxhpdvri 109 3 preview preview NN cord-349011-kxhpdvri 109 4 event event NN cord-349011-kxhpdvri 109 5 . . . cord-349011-kxhpdvri 110 1 Soapbox Soapbox NNP cord-349011-kxhpdvri 110 2 Science Science NNP cord-349011-kxhpdvri 110 3 is be VBZ cord-349011-kxhpdvri 110 4 a a DT cord-349011-kxhpdvri 110 5 science science NN cord-349011-kxhpdvri 110 6 communication communication NN cord-349011-kxhpdvri 110 7 event event NN cord-349011-kxhpdvri 110 8 in in IN cord-349011-kxhpdvri 110 9 which which WDT cord-349011-kxhpdvri 110 10 female female JJ cord-349011-kxhpdvri 110 11 scientists scientist NNS cord-349011-kxhpdvri 110 12 stand stand VBP cord-349011-kxhpdvri 110 13 on on IN cord-349011-kxhpdvri 110 14 " " `` cord-349011-kxhpdvri 110 15 soapboxes soapbox NNS cord-349011-kxhpdvri 110 16 " " '' cord-349011-kxhpdvri 110 17 ( ( -LRB- cord-349011-kxhpdvri 110 18 see see VB cord-349011-kxhpdvri 110 19 above above RB cord-349011-kxhpdvri 110 20 ) ) -RRB- cord-349011-kxhpdvri 110 21 and and CC cord-349011-kxhpdvri 110 22 discuss discuss VB cord-349011-kxhpdvri 110 23 their -PRON- PRP$ cord-349011-kxhpdvri 110 24 research research NN cord-349011-kxhpdvri 110 25 with with IN cord-349011-kxhpdvri 110 26 the the DT cord-349011-kxhpdvri 110 27 lay lay NN cord-349011-kxhpdvri 110 28 public public JJ cord-349011-kxhpdvri 110 29 using use VBG cord-349011-kxhpdvri 110 30 simple simple JJ cord-349011-kxhpdvri 110 31 props prop NNS cord-349011-kxhpdvri 110 32 . . . cord-349011-kxhpdvri 111 1 These these DT cord-349011-kxhpdvri 111 2 events event NNS cord-349011-kxhpdvri 111 3 are be VBP cord-349011-kxhpdvri 111 4 intended intend VBN cord-349011-kxhpdvri 111 5 to to TO cord-349011-kxhpdvri 111 6 boost boost VB cord-349011-kxhpdvri 111 7 the the DT cord-349011-kxhpdvri 111 8 visibility visibility NN cord-349011-kxhpdvri 111 9 of of IN cord-349011-kxhpdvri 111 10 female female JJ cord-349011-kxhpdvri 111 11 scientists scientist NNS cord-349011-kxhpdvri 111 12 and and CC cord-349011-kxhpdvri 111 13 inspire inspire VB cord-349011-kxhpdvri 111 14 the the DT cord-349011-kxhpdvri 111 15 next next JJ cord-349011-kxhpdvri 111 16 generation generation NN cord-349011-kxhpdvri 111 17 . . . cord-349011-kxhpdvri 112 1 In in IN cord-349011-kxhpdvri 112 2 this this DT cord-349011-kxhpdvri 112 3 photo photo NN cord-349011-kxhpdvri 112 4 , , , cord-349011-kxhpdvri 112 5 Dr. Dr. NNP cord-349011-kxhpdvri 112 6 Maya Maya NNP cord-349011-kxhpdvri 112 7 Shmulevitz Shmulevitz NNP cord-349011-kxhpdvri 112 8 ( ( -LRB- cord-349011-kxhpdvri 112 9 University University NNP cord-349011-kxhpdvri 112 10 of of IN cord-349011-kxhpdvri 112 11 Alberta Alberta NNP cord-349011-kxhpdvri 112 12 ) ) -RRB- cord-349011-kxhpdvri 112 13 is be VBZ cord-349011-kxhpdvri 112 14 explaining explain VBG cord-349011-kxhpdvri 112 15 her -PRON- PRP$ cord-349011-kxhpdvri 112 16 research research NN cord-349011-kxhpdvri 112 17 program program NN cord-349011-kxhpdvri 112 18 using use VBG cord-349011-kxhpdvri 112 19 art art NN cord-349011-kxhpdvri 112 20 supplies supply NNS cord-349011-kxhpdvri 112 21 and and CC cord-349011-kxhpdvri 112 22 candy candy NN cord-349011-kxhpdvri 112 23 ; ; : cord-349011-kxhpdvri 112 24 she -PRON- PRP cord-349011-kxhpdvri 112 25 is be VBZ cord-349011-kxhpdvri 112 26 illustrating illustrate VBG cord-349011-kxhpdvri 112 27 how how WRB cord-349011-kxhpdvri 112 28 scientists scientist NNS cord-349011-kxhpdvri 112 29 can can MD cord-349011-kxhpdvri 112 30 transform transform VB cord-349011-kxhpdvri 112 31 a a DT cord-349011-kxhpdvri 112 32 virus virus NN cord-349011-kxhpdvri 112 33 that that WDT cord-349011-kxhpdvri 112 34 CAUSES cause VBZ cord-349011-kxhpdvri 112 35 disease disease NN cord-349011-kxhpdvri 112 36 , , , cord-349011-kxhpdvri 112 37 into into IN cord-349011-kxhpdvri 112 38 a a DT cord-349011-kxhpdvri 112 39 virus virus NN cord-349011-kxhpdvri 112 40 that that WDT cord-349011-kxhpdvri 112 41 TREATS treat VBZ cord-349011-kxhpdvri 112 42 disease disease NN cord-349011-kxhpdvri 112 43 . . . cord-349011-kxhpdvri 113 1 Volunteer Volunteer NNP cord-349011-kxhpdvri 113 2 Lucas Lucas NNP cord-349011-kxhpdvri 113 3 Jarche Jarche NNP cord-349011-kxhpdvri 113 4 ( ( -LRB- cord-349011-kxhpdvri 113 5 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 113 6 University University NNP cord-349011-kxhpdvri 113 7 ) ) -RRB- cord-349011-kxhpdvri 113 8 is be VBZ cord-349011-kxhpdvri 113 9 seen see VBN cord-349011-kxhpdvri 113 10 here here RB cord-349011-kxhpdvri 113 11 holding hold VBG cord-349011-kxhpdvri 113 12 a a DT cord-349011-kxhpdvri 113 13 " " `` cord-349011-kxhpdvri 113 14 typical typical JJ cord-349011-kxhpdvri 113 15 healthy healthy JJ cord-349011-kxhpdvri 113 16 human human NN cord-349011-kxhpdvri 113 17 " " '' cord-349011-kxhpdvri 113 18 , , , cord-349011-kxhpdvri 113 19 which which WDT cord-349011-kxhpdvri 113 20 is be VBZ cord-349011-kxhpdvri 113 21 composed compose VBN cord-349011-kxhpdvri 113 22 of of IN cord-349011-kxhpdvri 113 23 many many JJ cord-349011-kxhpdvri 113 24 human human JJ cord-349011-kxhpdvri 113 25 organs organ NNS cord-349011-kxhpdvri 113 26 that that WDT cord-349011-kxhpdvri 113 27 each each DT cord-349011-kxhpdvri 113 28 have have VBP cord-349011-kxhpdvri 113 29 their -PRON- PRP$ cord-349011-kxhpdvri 113 30 own own JJ cord-349011-kxhpdvri 113 31 unique unique JJ cord-349011-kxhpdvri 113 32 features feature NNS cord-349011-kxhpdvri 113 33 ( ( -LRB- cord-349011-kxhpdvri 113 34 e.g. e.g. RB cord-349011-kxhpdvri 113 35 , , , cord-349011-kxhpdvri 113 36 bones bone NNS cord-349011-kxhpdvri 113 37 are be VBP cord-349011-kxhpdvri 113 38 licorice licorice NN cord-349011-kxhpdvri 113 39 , , , cord-349011-kxhpdvri 113 40 heart heart NN cord-349011-kxhpdvri 113 41 is be VBZ cord-349011-kxhpdvri 113 42 a a DT cord-349011-kxhpdvri 113 43 cherry cherry NN cord-349011-kxhpdvri 113 44 gummy gummy NN cord-349011-kxhpdvri 113 45 ) ) -RRB- cord-349011-kxhpdvri 113 46 . . . cord-349011-kxhpdvri 114 1 The the DT cord-349011-kxhpdvri 114 2 audience audience NN cord-349011-kxhpdvri 114 3 was be VBD cord-349011-kxhpdvri 114 4 asked ask VBN cord-349011-kxhpdvri 114 5 to to TO cord-349011-kxhpdvri 114 6 make make VB cord-349011-kxhpdvri 114 7 a a DT cord-349011-kxhpdvri 114 8 virus virus NN cord-349011-kxhpdvri 114 9 that that WDT cord-349011-kxhpdvri 114 10 targets target VBZ cord-349011-kxhpdvri 114 11 a a DT cord-349011-kxhpdvri 114 12 specific specific JJ cord-349011-kxhpdvri 114 13 organ organ NN cord-349011-kxhpdvri 114 14 , , , cord-349011-kxhpdvri 114 15 using use VBG cord-349011-kxhpdvri 114 16 the the DT cord-349011-kxhpdvri 114 17 corresponding corresponding JJ cord-349011-kxhpdvri 114 18 candy candy NN cord-349011-kxhpdvri 114 19 . . . cord-349011-kxhpdvri 115 1 For for IN cord-349011-kxhpdvri 115 2 example example NN cord-349011-kxhpdvri 115 3 , , , cord-349011-kxhpdvri 115 4 a a DT cord-349011-kxhpdvri 115 5 virus virus NN cord-349011-kxhpdvri 115 6 that that WDT cord-349011-kxhpdvri 115 7 homes home NNS cord-349011-kxhpdvri 115 8 to to IN cord-349011-kxhpdvri 115 9 the the DT cord-349011-kxhpdvri 115 10 heart heart NN cord-349011-kxhpdvri 115 11 would would MD cord-349011-kxhpdvri 115 12 have have VB cord-349011-kxhpdvri 115 13 evolved evolve VBN cord-349011-kxhpdvri 115 14 to to TO cord-349011-kxhpdvri 115 15 recognize recognize VB cord-349011-kxhpdvri 115 16 specific specific JJ cord-349011-kxhpdvri 115 17 features feature NNS cord-349011-kxhpdvri 115 18 of of IN cord-349011-kxhpdvri 115 19 the the DT cord-349011-kxhpdvri 115 20 heart heart NN cord-349011-kxhpdvri 115 21 / / SYM cord-349011-kxhpdvri 115 22 cherry cherry NN cord-349011-kxhpdvri 115 23 gummy gummy NN cord-349011-kxhpdvri 115 24 . . . cord-349011-kxhpdvri 116 1 Additional additional JJ cord-349011-kxhpdvri 116 2 features feature NNS cord-349011-kxhpdvri 116 3 of of IN cord-349011-kxhpdvri 116 4 viruses virus NNS cord-349011-kxhpdvri 116 5 were be VBD cord-349011-kxhpdvri 116 6 then then RB cord-349011-kxhpdvri 116 7 added add VBN cord-349011-kxhpdvri 116 8 ; ; : cord-349011-kxhpdvri 116 9 For for IN cord-349011-kxhpdvri 116 10 example example NN cord-349011-kxhpdvri 116 11 , , , cord-349011-kxhpdvri 116 12 viruses virus NNS cord-349011-kxhpdvri 116 13 that that WDT cord-349011-kxhpdvri 116 14 cause cause VBP cord-349011-kxhpdvri 116 15 disease disease NN cord-349011-kxhpdvri 116 16 often often RB cord-349011-kxhpdvri 116 17 interfere interfere VBP cord-349011-kxhpdvri 116 18 with with IN cord-349011-kxhpdvri 116 19 immune immune JJ cord-349011-kxhpdvri 116 20 responses response NNS cord-349011-kxhpdvri 116 21 , , , cord-349011-kxhpdvri 116 22 so so IN cord-349011-kxhpdvri 116 23 candies candy NNS cord-349011-kxhpdvri 116 24 were be VBD cord-349011-kxhpdvri 116 25 added add VBN cord-349011-kxhpdvri 116 26 to to TO cord-349011-kxhpdvri 116 27 represent represent VB cord-349011-kxhpdvri 116 28 these these DT cord-349011-kxhpdvri 116 29 attributes attribute NNS cord-349011-kxhpdvri 116 30 . . . cord-349011-kxhpdvri 117 1 Following follow VBG cord-349011-kxhpdvri 117 2 a a DT cord-349011-kxhpdvri 117 3 discussion discussion NN cord-349011-kxhpdvri 117 4 of of IN cord-349011-kxhpdvri 117 5 the the DT cord-349011-kxhpdvri 117 6 features feature NNS cord-349011-kxhpdvri 117 7 of of IN cord-349011-kxhpdvri 117 8 cancer cancer NN cord-349011-kxhpdvri 117 9 , , , cord-349011-kxhpdvri 117 10 the the DT cord-349011-kxhpdvri 117 11 audience audience NN cord-349011-kxhpdvri 117 12 were be VBD cord-349011-kxhpdvri 117 13 instructed instruct VBN cord-349011-kxhpdvri 117 14 to to TO cord-349011-kxhpdvri 117 15 modify modify VB cord-349011-kxhpdvri 117 16 their -PRON- PRP$ cord-349011-kxhpdvri 117 17 candy candy NN cord-349011-kxhpdvri 117 18 viruses virus NNS cord-349011-kxhpdvri 117 19 so so IN cord-349011-kxhpdvri 117 20 that that IN cord-349011-kxhpdvri 117 21 they -PRON- PRP cord-349011-kxhpdvri 117 22 will will MD cord-349011-kxhpdvri 117 23 target target VB cord-349011-kxhpdvri 117 24 cancer cancer NN cord-349011-kxhpdvri 117 25 cells cell NNS cord-349011-kxhpdvri 117 26 rather rather RB cord-349011-kxhpdvri 117 27 than than IN cord-349011-kxhpdvri 117 28 their -PRON- PRP$ cord-349011-kxhpdvri 117 29 natural natural JJ cord-349011-kxhpdvri 117 30 host host NN cord-349011-kxhpdvri 117 31 cells cell NNS cord-349011-kxhpdvri 117 32 . . . cord-349011-kxhpdvri 118 1 Following follow VBG cord-349011-kxhpdvri 118 2 the the DT cord-349011-kxhpdvri 118 3 Soapbox Soapbox NNP cord-349011-kxhpdvri 118 4 Science Science NNP cord-349011-kxhpdvri 118 5 preview preview NN cord-349011-kxhpdvri 118 6 , , , cord-349011-kxhpdvri 118 7 the the DT cord-349011-kxhpdvri 118 8 audience audience NN cord-349011-kxhpdvri 118 9 returned return VBD cord-349011-kxhpdvri 118 10 to to IN cord-349011-kxhpdvri 118 11 the the DT cord-349011-kxhpdvri 118 12 lecture lecture NN cord-349011-kxhpdvri 118 13 hall hall NN cord-349011-kxhpdvri 118 14 for for IN cord-349011-kxhpdvri 118 15 a a DT cord-349011-kxhpdvri 118 16 keynote keynote JJ cord-349011-kxhpdvri 118 17 lecture lecture NN cord-349011-kxhpdvri 118 18 from from IN cord-349011-kxhpdvri 118 19 Dr. Dr. NNP cord-349011-kxhpdvri 118 20 Kate Kate NNP cord-349011-kxhpdvri 118 21 O'Brien O'Brien NNP cord-349011-kxhpdvri 118 22 , , , cord-349011-kxhpdvri 118 23 then then RB cord-349011-kxhpdvri 118 24 from from IN cord-349011-kxhpdvri 118 25 Johns Johns NNP cord-349011-kxhpdvri 118 26 Hopkins Hopkins NNP cord-349011-kxhpdvri 118 27 Bloomberg Bloomberg NNP cord-349011-kxhpdvri 118 28 School School NNP cord-349011-kxhpdvri 118 29 of of IN cord-349011-kxhpdvri 118 30 Public Public NNP cord-349011-kxhpdvri 118 31 Health Health NNP cord-349011-kxhpdvri 118 32 , , , cord-349011-kxhpdvri 118 33 who who WP cord-349011-kxhpdvri 118 34 had have VBD cord-349011-kxhpdvri 118 35 recently recently RB cord-349011-kxhpdvri 118 36 been be VBN cord-349011-kxhpdvri 118 37 awarded award VBN cord-349011-kxhpdvri 118 38 a a DT cord-349011-kxhpdvri 118 39 prestigious prestigious JJ cord-349011-kxhpdvri 118 40 Canada Canada NNP cord-349011-kxhpdvri 118 41 150 150 CD cord-349011-kxhpdvri 118 42 Research Research NNP cord-349011-kxhpdvri 118 43 Chair Chair NNP cord-349011-kxhpdvri 118 44 to to TO cord-349011-kxhpdvri 118 45 support support VB cord-349011-kxhpdvri 118 46 her -PRON- PRP$ cord-349011-kxhpdvri 118 47 recruitment recruitment NN cord-349011-kxhpdvri 118 48 to to IN cord-349011-kxhpdvri 118 49 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 118 50 University University NNP cord-349011-kxhpdvri 119 1 ( ( -LRB- cord-349011-kxhpdvri 119 2 Dr. Dr. NNP cord-349011-kxhpdvri 119 3 O'Brien O'Brien NNP cord-349011-kxhpdvri 119 4 was be VBD cord-349011-kxhpdvri 119 5 subsequently subsequently RB cord-349011-kxhpdvri 119 6 recruited recruit VBN cord-349011-kxhpdvri 119 7 by by IN cord-349011-kxhpdvri 119 8 World World NNP cord-349011-kxhpdvri 119 9 Health Health NNP cord-349011-kxhpdvri 119 10 Organization Organization NNP cord-349011-kxhpdvri 119 11 in in IN cord-349011-kxhpdvri 119 12 Geneva Geneva NNP cord-349011-kxhpdvri 119 13 , , , cord-349011-kxhpdvri 119 14 Switzerland Switzerland NNP cord-349011-kxhpdvri 119 15 , , , cord-349011-kxhpdvri 119 16 where where WRB cord-349011-kxhpdvri 119 17 she -PRON- PRP cord-349011-kxhpdvri 119 18 is be VBZ cord-349011-kxhpdvri 119 19 Director Director NNP cord-349011-kxhpdvri 119 20 of of IN cord-349011-kxhpdvri 119 21 Immunization Immunization NNP cord-349011-kxhpdvri 119 22 , , , cord-349011-kxhpdvri 119 23 Vaccines Vaccines NNPS cord-349011-kxhpdvri 119 24 and and CC cord-349011-kxhpdvri 119 25 Biologicals Biologicals NNP cord-349011-kxhpdvri 119 26 ) ) -RRB- cord-349011-kxhpdvri 119 27 . . . cord-349011-kxhpdvri 120 1 Dr. Dr. NNP cord-349011-kxhpdvri 120 2 O'Brien O'Brien NNP cord-349011-kxhpdvri 120 3 's 's POS cord-349011-kxhpdvri 120 4 scientific scientific JJ cord-349011-kxhpdvri 120 5 and and CC cord-349011-kxhpdvri 120 6 policy policy NN cord-349011-kxhpdvri 120 7 work work NN cord-349011-kxhpdvri 120 8 is be VBZ cord-349011-kxhpdvri 120 9 focused focus VBN cord-349011-kxhpdvri 120 10 on on IN cord-349011-kxhpdvri 120 11 vaccine vaccine NN cord-349011-kxhpdvri 120 12 - - HYPH cord-349011-kxhpdvri 120 13 preventable preventable JJ cord-349011-kxhpdvri 120 14 illnesses illness NNS cord-349011-kxhpdvri 120 15 in in IN cord-349011-kxhpdvri 120 16 children child NNS cord-349011-kxhpdvri 120 17 and and CC cord-349011-kxhpdvri 120 18 adults adult NNS cord-349011-kxhpdvri 120 19 . . . cord-349011-kxhpdvri 121 1 She -PRON- PRP cord-349011-kxhpdvri 121 2 reported report VBD cord-349011-kxhpdvri 121 3 on on IN cord-349011-kxhpdvri 121 4 results result NNS cord-349011-kxhpdvri 121 5 from from IN cord-349011-kxhpdvri 121 6 the the DT cord-349011-kxhpdvri 121 7 Pneumonia Pneumonia NNP cord-349011-kxhpdvri 121 8 Etiology Etiology NNP cord-349011-kxhpdvri 121 9 Research Research NNP cord-349011-kxhpdvri 121 10 for for IN cord-349011-kxhpdvri 121 11 Child Child NNP cord-349011-kxhpdvri 121 12 Health Health NNP cord-349011-kxhpdvri 121 13 ( ( -LRB- cord-349011-kxhpdvri 121 14 PERCH PERCH NNP cord-349011-kxhpdvri 121 15 ) ) -RRB- cord-349011-kxhpdvri 121 16 study study NN cord-349011-kxhpdvri 121 17 , , , cord-349011-kxhpdvri 121 18 which which WDT cord-349011-kxhpdvri 121 19 is be VBZ cord-349011-kxhpdvri 121 20 a a DT cord-349011-kxhpdvri 121 21 collaborative collaborative JJ cord-349011-kxhpdvri 121 22 study study NN cord-349011-kxhpdvri 121 23 of of IN cord-349011-kxhpdvri 121 24 populations population NNS cord-349011-kxhpdvri 121 25 in in IN cord-349011-kxhpdvri 121 26 seven seven CD cord-349011-kxhpdvri 121 27 countries country NNS cord-349011-kxhpdvri 121 28 in in IN cord-349011-kxhpdvri 121 29 Africa Africa NNP cord-349011-kxhpdvri 121 30 and and CC cord-349011-kxhpdvri 121 31 Asia Asia NNP cord-349011-kxhpdvri 121 32 designed design VBN cord-349011-kxhpdvri 121 33 to to TO cord-349011-kxhpdvri 121 34 determine determine VB cord-349011-kxhpdvri 121 35 the the DT cord-349011-kxhpdvri 121 36 etiology etiology NN cord-349011-kxhpdvri 121 37 of of IN cord-349011-kxhpdvri 121 38 severe severe JJ cord-349011-kxhpdvri 121 39 pediatric pediatric JJ cord-349011-kxhpdvri 121 40 pneumonia pneumonia NN cord-349011-kxhpdvri 121 41 in in IN cord-349011-kxhpdvri 121 42 the the DT cord-349011-kxhpdvri 121 43 context context NN cord-349011-kxhpdvri 121 44 of of IN cord-349011-kxhpdvri 121 45 widespread widespread JJ cord-349011-kxhpdvri 121 46 conjugate conjugate NN cord-349011-kxhpdvri 121 47 Hemophilus Hemophilus NNP cord-349011-kxhpdvri 121 48 influenzae influenzae NN cord-349011-kxhpdvri 121 49 type type NN cord-349011-kxhpdvri 121 50 B b NN cord-349011-kxhpdvri 121 51 ( ( -LRB- cord-349011-kxhpdvri 121 52 Hib Hib NNP cord-349011-kxhpdvri 121 53 ) ) -RRB- cord-349011-kxhpdvri 121 54 and and CC cord-349011-kxhpdvri 121 55 pneumococcal pneumococcal JJ cord-349011-kxhpdvri 121 56 vaccination vaccination NN cord-349011-kxhpdvri 121 57 [ [ -LRB- cord-349011-kxhpdvri 121 58 32 32 CD cord-349011-kxhpdvri 121 59 ] ] -RRB- cord-349011-kxhpdvri 121 60 . . . cord-349011-kxhpdvri 122 1 The the DT cord-349011-kxhpdvri 122 2 study study NN cord-349011-kxhpdvri 122 3 included include VBD cord-349011-kxhpdvri 122 4 over over IN cord-349011-kxhpdvri 122 5 4000 4000 CD cord-349011-kxhpdvri 122 6 hospitalized hospitalize VBN cord-349011-kxhpdvri 122 7 Soapbox Soapbox NNP cord-349011-kxhpdvri 122 8 Science Science NNP cord-349011-kxhpdvri 122 9 is be VBZ cord-349011-kxhpdvri 122 10 a a DT cord-349011-kxhpdvri 122 11 science science NN cord-349011-kxhpdvri 122 12 communication communication NN cord-349011-kxhpdvri 122 13 event event NN cord-349011-kxhpdvri 122 14 in in IN cord-349011-kxhpdvri 122 15 which which WDT cord-349011-kxhpdvri 122 16 female female JJ cord-349011-kxhpdvri 122 17 scientists scientist NNS cord-349011-kxhpdvri 122 18 stand stand VBP cord-349011-kxhpdvri 122 19 on on IN cord-349011-kxhpdvri 122 20 " " `` cord-349011-kxhpdvri 122 21 soapboxes soapbox NNS cord-349011-kxhpdvri 122 22 " " '' cord-349011-kxhpdvri 122 23 ( ( -LRB- cord-349011-kxhpdvri 122 24 see see VB cord-349011-kxhpdvri 122 25 above above RB cord-349011-kxhpdvri 122 26 ) ) -RRB- cord-349011-kxhpdvri 122 27 and and CC cord-349011-kxhpdvri 122 28 discuss discuss VB cord-349011-kxhpdvri 122 29 their -PRON- PRP$ cord-349011-kxhpdvri 122 30 research research NN cord-349011-kxhpdvri 122 31 with with IN cord-349011-kxhpdvri 122 32 the the DT cord-349011-kxhpdvri 122 33 lay lay NN cord-349011-kxhpdvri 122 34 public public JJ cord-349011-kxhpdvri 122 35 using use VBG cord-349011-kxhpdvri 122 36 simple simple JJ cord-349011-kxhpdvri 122 37 props prop NNS cord-349011-kxhpdvri 122 38 . . . cord-349011-kxhpdvri 123 1 These these DT cord-349011-kxhpdvri 123 2 events event NNS cord-349011-kxhpdvri 123 3 are be VBP cord-349011-kxhpdvri 123 4 intended intend VBN cord-349011-kxhpdvri 123 5 to to TO cord-349011-kxhpdvri 123 6 boost boost VB cord-349011-kxhpdvri 123 7 the the DT cord-349011-kxhpdvri 123 8 visibility visibility NN cord-349011-kxhpdvri 123 9 of of IN cord-349011-kxhpdvri 123 10 female female JJ cord-349011-kxhpdvri 123 11 scientists scientist NNS cord-349011-kxhpdvri 123 12 and and CC cord-349011-kxhpdvri 123 13 inspire inspire VB cord-349011-kxhpdvri 123 14 the the DT cord-349011-kxhpdvri 123 15 next next JJ cord-349011-kxhpdvri 123 16 generation generation NN cord-349011-kxhpdvri 123 17 . . . cord-349011-kxhpdvri 124 1 In in IN cord-349011-kxhpdvri 124 2 this this DT cord-349011-kxhpdvri 124 3 photo photo NN cord-349011-kxhpdvri 124 4 , , , cord-349011-kxhpdvri 124 5 Dr. Dr. NNP cord-349011-kxhpdvri 124 6 Maya Maya NNP cord-349011-kxhpdvri 124 7 Shmulevitz Shmulevitz NNP cord-349011-kxhpdvri 124 8 ( ( -LRB- cord-349011-kxhpdvri 124 9 University University NNP cord-349011-kxhpdvri 124 10 of of IN cord-349011-kxhpdvri 124 11 Alberta Alberta NNP cord-349011-kxhpdvri 124 12 ) ) -RRB- cord-349011-kxhpdvri 124 13 is be VBZ cord-349011-kxhpdvri 124 14 explaining explain VBG cord-349011-kxhpdvri 124 15 her -PRON- PRP$ cord-349011-kxhpdvri 124 16 research research NN cord-349011-kxhpdvri 124 17 program program NN cord-349011-kxhpdvri 124 18 using use VBG cord-349011-kxhpdvri 124 19 art art NN cord-349011-kxhpdvri 124 20 supplies supply NNS cord-349011-kxhpdvri 124 21 and and CC cord-349011-kxhpdvri 124 22 candy candy NN cord-349011-kxhpdvri 124 23 ; ; : cord-349011-kxhpdvri 124 24 she -PRON- PRP cord-349011-kxhpdvri 124 25 is be VBZ cord-349011-kxhpdvri 124 26 illustrating illustrate VBG cord-349011-kxhpdvri 124 27 how how WRB cord-349011-kxhpdvri 124 28 scientists scientist NNS cord-349011-kxhpdvri 124 29 can can MD cord-349011-kxhpdvri 124 30 transform transform VB cord-349011-kxhpdvri 124 31 a a DT cord-349011-kxhpdvri 124 32 virus virus NN cord-349011-kxhpdvri 124 33 that that WDT cord-349011-kxhpdvri 124 34 CAUSES cause VBZ cord-349011-kxhpdvri 124 35 disease disease NN cord-349011-kxhpdvri 124 36 , , , cord-349011-kxhpdvri 124 37 into into IN cord-349011-kxhpdvri 124 38 a a DT cord-349011-kxhpdvri 124 39 virus virus NN cord-349011-kxhpdvri 124 40 that that WDT cord-349011-kxhpdvri 124 41 TREATS treat VBZ cord-349011-kxhpdvri 124 42 disease disease NN cord-349011-kxhpdvri 124 43 . . . cord-349011-kxhpdvri 125 1 Volunteer Volunteer NNP cord-349011-kxhpdvri 125 2 Lucas Lucas NNP cord-349011-kxhpdvri 125 3 Jarche Jarche NNP cord-349011-kxhpdvri 125 4 ( ( -LRB- cord-349011-kxhpdvri 125 5 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 125 6 University University NNP cord-349011-kxhpdvri 125 7 ) ) -RRB- cord-349011-kxhpdvri 125 8 is be VBZ cord-349011-kxhpdvri 125 9 seen see VBN cord-349011-kxhpdvri 125 10 here here RB cord-349011-kxhpdvri 125 11 holding hold VBG cord-349011-kxhpdvri 125 12 a a DT cord-349011-kxhpdvri 125 13 " " `` cord-349011-kxhpdvri 125 14 typical typical JJ cord-349011-kxhpdvri 125 15 healthy healthy JJ cord-349011-kxhpdvri 125 16 human human NN cord-349011-kxhpdvri 125 17 " " '' cord-349011-kxhpdvri 125 18 , , , cord-349011-kxhpdvri 125 19 which which WDT cord-349011-kxhpdvri 125 20 is be VBZ cord-349011-kxhpdvri 125 21 composed compose VBN cord-349011-kxhpdvri 125 22 of of IN cord-349011-kxhpdvri 125 23 many many JJ cord-349011-kxhpdvri 125 24 human human JJ cord-349011-kxhpdvri 125 25 organs organ NNS cord-349011-kxhpdvri 125 26 that that WDT cord-349011-kxhpdvri 125 27 each each DT cord-349011-kxhpdvri 125 28 have have VBP cord-349011-kxhpdvri 125 29 their -PRON- PRP$ cord-349011-kxhpdvri 125 30 own own JJ cord-349011-kxhpdvri 125 31 unique unique JJ cord-349011-kxhpdvri 125 32 features feature NNS cord-349011-kxhpdvri 125 33 ( ( -LRB- cord-349011-kxhpdvri 125 34 e.g. e.g. RB cord-349011-kxhpdvri 125 35 , , , cord-349011-kxhpdvri 125 36 bones bone NNS cord-349011-kxhpdvri 125 37 are be VBP cord-349011-kxhpdvri 125 38 licorice licorice NN cord-349011-kxhpdvri 125 39 , , , cord-349011-kxhpdvri 125 40 heart heart NN cord-349011-kxhpdvri 125 41 is be VBZ cord-349011-kxhpdvri 125 42 a a DT cord-349011-kxhpdvri 125 43 cherry cherry NN cord-349011-kxhpdvri 125 44 gummy gummy NN cord-349011-kxhpdvri 125 45 ) ) -RRB- cord-349011-kxhpdvri 125 46 . . . cord-349011-kxhpdvri 126 1 The the DT cord-349011-kxhpdvri 126 2 audience audience NN cord-349011-kxhpdvri 126 3 was be VBD cord-349011-kxhpdvri 126 4 asked ask VBN cord-349011-kxhpdvri 126 5 to to TO cord-349011-kxhpdvri 126 6 make make VB cord-349011-kxhpdvri 126 7 a a DT cord-349011-kxhpdvri 126 8 virus virus NN cord-349011-kxhpdvri 126 9 that that WDT cord-349011-kxhpdvri 126 10 targets target VBZ cord-349011-kxhpdvri 126 11 a a DT cord-349011-kxhpdvri 126 12 specific specific JJ cord-349011-kxhpdvri 126 13 organ organ NN cord-349011-kxhpdvri 126 14 , , , cord-349011-kxhpdvri 126 15 using use VBG cord-349011-kxhpdvri 126 16 the the DT cord-349011-kxhpdvri 126 17 corresponding corresponding JJ cord-349011-kxhpdvri 126 18 candy candy NN cord-349011-kxhpdvri 126 19 . . . cord-349011-kxhpdvri 127 1 For for IN cord-349011-kxhpdvri 127 2 example example NN cord-349011-kxhpdvri 127 3 , , , cord-349011-kxhpdvri 127 4 a a DT cord-349011-kxhpdvri 127 5 virus virus NN cord-349011-kxhpdvri 127 6 that that WDT cord-349011-kxhpdvri 127 7 homes home NNS cord-349011-kxhpdvri 127 8 to to IN cord-349011-kxhpdvri 127 9 the the DT cord-349011-kxhpdvri 127 10 heart heart NN cord-349011-kxhpdvri 127 11 would would MD cord-349011-kxhpdvri 127 12 have have VB cord-349011-kxhpdvri 127 13 evolved evolve VBN cord-349011-kxhpdvri 127 14 to to TO cord-349011-kxhpdvri 127 15 recognize recognize VB cord-349011-kxhpdvri 127 16 specific specific JJ cord-349011-kxhpdvri 127 17 features feature NNS cord-349011-kxhpdvri 127 18 of of IN cord-349011-kxhpdvri 127 19 the the DT cord-349011-kxhpdvri 127 20 heart heart NN cord-349011-kxhpdvri 127 21 / / SYM cord-349011-kxhpdvri 127 22 cherry cherry NN cord-349011-kxhpdvri 127 23 gummy gummy NN cord-349011-kxhpdvri 127 24 . . . cord-349011-kxhpdvri 128 1 Additional additional JJ cord-349011-kxhpdvri 128 2 features feature NNS cord-349011-kxhpdvri 128 3 of of IN cord-349011-kxhpdvri 128 4 viruses virus NNS cord-349011-kxhpdvri 128 5 were be VBD cord-349011-kxhpdvri 128 6 then then RB cord-349011-kxhpdvri 128 7 added add VBN cord-349011-kxhpdvri 128 8 ; ; : cord-349011-kxhpdvri 128 9 For for IN cord-349011-kxhpdvri 128 10 example example NN cord-349011-kxhpdvri 128 11 , , , cord-349011-kxhpdvri 128 12 viruses virus NNS cord-349011-kxhpdvri 128 13 that that WDT cord-349011-kxhpdvri 128 14 cause cause VBP cord-349011-kxhpdvri 128 15 disease disease NN cord-349011-kxhpdvri 128 16 often often RB cord-349011-kxhpdvri 128 17 interfere interfere VBP cord-349011-kxhpdvri 128 18 with with IN cord-349011-kxhpdvri 128 19 immune immune JJ cord-349011-kxhpdvri 128 20 responses response NNS cord-349011-kxhpdvri 128 21 , , , cord-349011-kxhpdvri 128 22 so so IN cord-349011-kxhpdvri 128 23 candies candy NNS cord-349011-kxhpdvri 128 24 were be VBD cord-349011-kxhpdvri 128 25 added add VBN cord-349011-kxhpdvri 128 26 to to TO cord-349011-kxhpdvri 128 27 represent represent VB cord-349011-kxhpdvri 128 28 these these DT cord-349011-kxhpdvri 128 29 attributes attribute NNS cord-349011-kxhpdvri 128 30 . . . cord-349011-kxhpdvri 129 1 Following follow VBG cord-349011-kxhpdvri 129 2 a a DT cord-349011-kxhpdvri 129 3 discussion discussion NN cord-349011-kxhpdvri 129 4 of of IN cord-349011-kxhpdvri 129 5 the the DT cord-349011-kxhpdvri 129 6 features feature NNS cord-349011-kxhpdvri 129 7 of of IN cord-349011-kxhpdvri 129 8 cancer cancer NN cord-349011-kxhpdvri 129 9 , , , cord-349011-kxhpdvri 129 10 the the DT cord-349011-kxhpdvri 129 11 audience audience NN cord-349011-kxhpdvri 129 12 were be VBD cord-349011-kxhpdvri 129 13 instructed instruct VBN cord-349011-kxhpdvri 129 14 to to TO cord-349011-kxhpdvri 129 15 modify modify VB cord-349011-kxhpdvri 129 16 their -PRON- PRP$ cord-349011-kxhpdvri 129 17 candy candy NN cord-349011-kxhpdvri 129 18 viruses virus NNS cord-349011-kxhpdvri 129 19 so so IN cord-349011-kxhpdvri 129 20 that that IN cord-349011-kxhpdvri 129 21 they -PRON- PRP cord-349011-kxhpdvri 129 22 will will MD cord-349011-kxhpdvri 129 23 target target VB cord-349011-kxhpdvri 129 24 cancer cancer NN cord-349011-kxhpdvri 129 25 cells cell NNS cord-349011-kxhpdvri 129 26 rather rather RB cord-349011-kxhpdvri 129 27 than than IN cord-349011-kxhpdvri 129 28 their -PRON- PRP$ cord-349011-kxhpdvri 129 29 natural natural JJ cord-349011-kxhpdvri 129 30 host host NN cord-349011-kxhpdvri 129 31 cells cell NNS cord-349011-kxhpdvri 129 32 . . . cord-349011-kxhpdvri 130 1 Following follow VBG cord-349011-kxhpdvri 130 2 the the DT cord-349011-kxhpdvri 130 3 Soapbox Soapbox NNP cord-349011-kxhpdvri 130 4 Science Science NNP cord-349011-kxhpdvri 130 5 preview preview NN cord-349011-kxhpdvri 130 6 , , , cord-349011-kxhpdvri 130 7 the the DT cord-349011-kxhpdvri 130 8 audience audience NN cord-349011-kxhpdvri 130 9 returned return VBD cord-349011-kxhpdvri 130 10 to to IN cord-349011-kxhpdvri 130 11 the the DT cord-349011-kxhpdvri 130 12 lecture lecture NN cord-349011-kxhpdvri 130 13 hall hall NN cord-349011-kxhpdvri 130 14 for for IN cord-349011-kxhpdvri 130 15 a a DT cord-349011-kxhpdvri 130 16 keynote keynote JJ cord-349011-kxhpdvri 130 17 lecture lecture NN cord-349011-kxhpdvri 130 18 from from IN cord-349011-kxhpdvri 130 19 Dr. Dr. NNP cord-349011-kxhpdvri 130 20 Kate Kate NNP cord-349011-kxhpdvri 130 21 O'Brien O'Brien NNP cord-349011-kxhpdvri 130 22 , , , cord-349011-kxhpdvri 130 23 then then RB cord-349011-kxhpdvri 130 24 from from IN cord-349011-kxhpdvri 130 25 Johns Johns NNP cord-349011-kxhpdvri 130 26 Hopkins Hopkins NNP cord-349011-kxhpdvri 130 27 Bloomberg Bloomberg NNP cord-349011-kxhpdvri 130 28 School School NNP cord-349011-kxhpdvri 130 29 of of IN cord-349011-kxhpdvri 130 30 Public Public NNP cord-349011-kxhpdvri 130 31 Health Health NNP cord-349011-kxhpdvri 130 32 , , , cord-349011-kxhpdvri 130 33 who who WP cord-349011-kxhpdvri 130 34 had have VBD cord-349011-kxhpdvri 130 35 recently recently RB cord-349011-kxhpdvri 130 36 been be VBN cord-349011-kxhpdvri 130 37 awarded award VBN cord-349011-kxhpdvri 130 38 a a DT cord-349011-kxhpdvri 130 39 prestigious prestigious JJ cord-349011-kxhpdvri 130 40 Canada Canada NNP cord-349011-kxhpdvri 130 41 150 150 CD cord-349011-kxhpdvri 130 42 Research Research NNP cord-349011-kxhpdvri 130 43 Chair Chair NNP cord-349011-kxhpdvri 130 44 to to TO cord-349011-kxhpdvri 130 45 support support VB cord-349011-kxhpdvri 130 46 her -PRON- PRP$ cord-349011-kxhpdvri 130 47 recruitment recruitment NN cord-349011-kxhpdvri 130 48 to to IN cord-349011-kxhpdvri 130 49 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 130 50 University University NNP cord-349011-kxhpdvri 131 1 ( ( -LRB- cord-349011-kxhpdvri 131 2 Dr. Dr. NNP cord-349011-kxhpdvri 131 3 O'Brien O'Brien NNP cord-349011-kxhpdvri 131 4 was be VBD cord-349011-kxhpdvri 131 5 subsequently subsequently RB cord-349011-kxhpdvri 131 6 recruited recruit VBN cord-349011-kxhpdvri 131 7 by by IN cord-349011-kxhpdvri 131 8 World World NNP cord-349011-kxhpdvri 131 9 Health Health NNP cord-349011-kxhpdvri 131 10 Organization Organization NNP cord-349011-kxhpdvri 131 11 in in IN cord-349011-kxhpdvri 131 12 Geneva Geneva NNP cord-349011-kxhpdvri 131 13 , , , cord-349011-kxhpdvri 131 14 Switzerland Switzerland NNP cord-349011-kxhpdvri 131 15 , , , cord-349011-kxhpdvri 131 16 where where WRB cord-349011-kxhpdvri 131 17 she -PRON- PRP cord-349011-kxhpdvri 131 18 is be VBZ cord-349011-kxhpdvri 131 19 Director Director NNP cord-349011-kxhpdvri 131 20 of of IN cord-349011-kxhpdvri 131 21 Immunization Immunization NNP cord-349011-kxhpdvri 131 22 , , , cord-349011-kxhpdvri 131 23 Vaccines Vaccines NNPS cord-349011-kxhpdvri 131 24 and and CC cord-349011-kxhpdvri 131 25 Biologicals Biologicals NNP cord-349011-kxhpdvri 131 26 ) ) -RRB- cord-349011-kxhpdvri 131 27 . . . cord-349011-kxhpdvri 132 1 Dr. Dr. NNP cord-349011-kxhpdvri 132 2 O'Brien O'Brien NNP cord-349011-kxhpdvri 132 3 's 's POS cord-349011-kxhpdvri 132 4 scientific scientific JJ cord-349011-kxhpdvri 132 5 and and CC cord-349011-kxhpdvri 132 6 policy policy NN cord-349011-kxhpdvri 132 7 work work NN cord-349011-kxhpdvri 132 8 is be VBZ cord-349011-kxhpdvri 132 9 focused focus VBN cord-349011-kxhpdvri 132 10 on on IN cord-349011-kxhpdvri 132 11 vaccine vaccine NN cord-349011-kxhpdvri 132 12 - - HYPH cord-349011-kxhpdvri 132 13 preventable preventable JJ cord-349011-kxhpdvri 132 14 illnesses illness NNS cord-349011-kxhpdvri 132 15 in in IN cord-349011-kxhpdvri 132 16 children child NNS cord-349011-kxhpdvri 132 17 and and CC cord-349011-kxhpdvri 132 18 adults adult NNS cord-349011-kxhpdvri 132 19 . . . cord-349011-kxhpdvri 133 1 She -PRON- PRP cord-349011-kxhpdvri 133 2 reported report VBD cord-349011-kxhpdvri 133 3 on on IN cord-349011-kxhpdvri 133 4 results result NNS cord-349011-kxhpdvri 133 5 from from IN cord-349011-kxhpdvri 133 6 the the DT cord-349011-kxhpdvri 133 7 Pneumonia Pneumonia NNP cord-349011-kxhpdvri 133 8 Etiology Etiology NNP cord-349011-kxhpdvri 133 9 Research Research NNP cord-349011-kxhpdvri 133 10 for for IN cord-349011-kxhpdvri 133 11 Child Child NNP cord-349011-kxhpdvri 133 12 Health Health NNP cord-349011-kxhpdvri 133 13 ( ( -LRB- cord-349011-kxhpdvri 133 14 PERCH PERCH NNP cord-349011-kxhpdvri 133 15 ) ) -RRB- cord-349011-kxhpdvri 133 16 study study NN cord-349011-kxhpdvri 133 17 , , , cord-349011-kxhpdvri 133 18 which which WDT cord-349011-kxhpdvri 133 19 is be VBZ cord-349011-kxhpdvri 133 20 a a DT cord-349011-kxhpdvri 133 21 collaborative collaborative JJ cord-349011-kxhpdvri 133 22 study study NN cord-349011-kxhpdvri 133 23 of of IN cord-349011-kxhpdvri 133 24 populations population NNS cord-349011-kxhpdvri 133 25 in in IN cord-349011-kxhpdvri 133 26 seven seven CD cord-349011-kxhpdvri 133 27 countries country NNS cord-349011-kxhpdvri 133 28 in in IN cord-349011-kxhpdvri 133 29 Africa Africa NNP cord-349011-kxhpdvri 133 30 and and CC cord-349011-kxhpdvri 133 31 Asia Asia NNP cord-349011-kxhpdvri 133 32 designed design VBN cord-349011-kxhpdvri 133 33 to to TO cord-349011-kxhpdvri 133 34 determine determine VB cord-349011-kxhpdvri 133 35 the the DT cord-349011-kxhpdvri 133 36 etiology etiology NN cord-349011-kxhpdvri 133 37 of of IN cord-349011-kxhpdvri 133 38 severe severe JJ cord-349011-kxhpdvri 133 39 pediatric pediatric JJ cord-349011-kxhpdvri 133 40 pneumonia pneumonia NN cord-349011-kxhpdvri 133 41 in in IN cord-349011-kxhpdvri 133 42 the the DT cord-349011-kxhpdvri 133 43 context context NN cord-349011-kxhpdvri 133 44 of of IN cord-349011-kxhpdvri 133 45 widespread widespread JJ cord-349011-kxhpdvri 133 46 conjugate conjugate NN cord-349011-kxhpdvri 133 47 Hemophilus Hemophilus NNP cord-349011-kxhpdvri 133 48 influenzae influenzae NN cord-349011-kxhpdvri 133 49 type type NN cord-349011-kxhpdvri 133 50 B b NN cord-349011-kxhpdvri 133 51 ( ( -LRB- cord-349011-kxhpdvri 133 52 Hib Hib NNP cord-349011-kxhpdvri 133 53 ) ) -RRB- cord-349011-kxhpdvri 133 54 and and CC cord-349011-kxhpdvri 133 55 pneumococcal pneumococcal JJ cord-349011-kxhpdvri 133 56 vaccination vaccination NN cord-349011-kxhpdvri 133 57 [ [ -LRB- cord-349011-kxhpdvri 133 58 32 32 CD cord-349011-kxhpdvri 133 59 ] ] -RRB- cord-349011-kxhpdvri 133 60 . . . cord-349011-kxhpdvri 134 1 The the DT cord-349011-kxhpdvri 134 2 study study NN cord-349011-kxhpdvri 134 3 included include VBD cord-349011-kxhpdvri 134 4 over over IN cord-349011-kxhpdvri 134 5 4000 4000 CD cord-349011-kxhpdvri 134 6 hospitalized hospitalize VBN cord-349011-kxhpdvri 134 7 children child NNS cord-349011-kxhpdvri 134 8 0 0 CD cord-349011-kxhpdvri 134 9 to to IN cord-349011-kxhpdvri 134 10 59 59 CD cord-349011-kxhpdvri 134 11 months month NNS cord-349011-kxhpdvri 134 12 of of IN cord-349011-kxhpdvri 134 13 age age NN cord-349011-kxhpdvri 134 14 , , , cord-349011-kxhpdvri 134 15 and and CC cord-349011-kxhpdvri 134 16 analysis analysis NN cord-349011-kxhpdvri 134 17 including include VBG cord-349011-kxhpdvri 134 18 molecular molecular JJ cord-349011-kxhpdvri 134 19 and and CC cord-349011-kxhpdvri 134 20 culture culture NN cord-349011-kxhpdvri 134 21 methods method NNS cord-349011-kxhpdvri 134 22 , , , cord-349011-kxhpdvri 134 23 chest chest NN cord-349011-kxhpdvri 134 24 x x NNS cord-349011-kxhpdvri 134 25 - - NNS cord-349011-kxhpdvri 134 26 rays ray NNS cord-349011-kxhpdvri 134 27 and and CC cord-349011-kxhpdvri 134 28 descriptive descriptive JJ cord-349011-kxhpdvri 134 29 etiology etiology NN cord-349011-kxhpdvri 134 30 analysis analysis NN cord-349011-kxhpdvri 134 31 . . . cord-349011-kxhpdvri 135 1 The the DT cord-349011-kxhpdvri 135 2 PERCH perch NN cord-349011-kxhpdvri 135 3 study study NN cord-349011-kxhpdvri 135 4 identified identify VBD cord-349011-kxhpdvri 135 5 the the DT cord-349011-kxhpdvri 135 6 frequency frequency NN cord-349011-kxhpdvri 135 7 of of IN cord-349011-kxhpdvri 135 8 etiologic etiologic NNP cord-349011-kxhpdvri 135 9 association association NNP cord-349011-kxhpdvri 135 10 of of IN cord-349011-kxhpdvri 135 11 different different JJ cord-349011-kxhpdvri 135 12 viruses virus NNS cord-349011-kxhpdvri 135 13 with with IN cord-349011-kxhpdvri 135 14 severe severe JJ cord-349011-kxhpdvri 135 15 childhood childhood NN cord-349011-kxhpdvri 135 16 pneumonia pneumonia NN cord-349011-kxhpdvri 135 17 , , , cord-349011-kxhpdvri 135 18 which which WDT cord-349011-kxhpdvri 135 19 notably notably RB cord-349011-kxhpdvri 135 20 included include VBD cord-349011-kxhpdvri 135 21 RSV RSV NNP cord-349011-kxhpdvri 135 22 , , , cord-349011-kxhpdvri 135 23 widely widely RB cord-349011-kxhpdvri 135 24 recognized recognize VBN cord-349011-kxhpdvri 135 25 as as IN cord-349011-kxhpdvri 135 26 a a DT cord-349011-kxhpdvri 135 27 major major JJ cord-349011-kxhpdvri 135 28 cause cause NN cord-349011-kxhpdvri 135 29 of of IN cord-349011-kxhpdvri 135 30 childhood childhood NN cord-349011-kxhpdvri 135 31 mortality mortality NN cord-349011-kxhpdvri 135 32 worldwide worldwide RB cord-349011-kxhpdvri 135 33 [ [ -LRB- cord-349011-kxhpdvri 135 34 33 33 CD cord-349011-kxhpdvri 135 35 ] ] -RRB- cord-349011-kxhpdvri 135 36 . . . cord-349011-kxhpdvri 136 1 After after IN cord-349011-kxhpdvri 136 2 the the DT cord-349011-kxhpdvri 136 3 lecture lecture NN cord-349011-kxhpdvri 136 4 , , , cord-349011-kxhpdvri 136 5 the the DT cord-349011-kxhpdvri 136 6 audience audience NN cord-349011-kxhpdvri 136 7 adjourned adjourn VBD cord-349011-kxhpdvri 136 8 to to IN cord-349011-kxhpdvri 136 9 an an DT cord-349011-kxhpdvri 136 10 evening evening NN cord-349011-kxhpdvri 136 11 at at IN cord-349011-kxhpdvri 136 12 second second JJ cord-349011-kxhpdvri 136 13 poster poster NN cord-349011-kxhpdvri 136 14 session session NN cord-349011-kxhpdvri 136 15 , , , cord-349011-kxhpdvri 136 16 after after IN cord-349011-kxhpdvri 136 17 which which WDT cord-349011-kxhpdvri 136 18 , , , cord-349011-kxhpdvri 136 19 many many JJ cord-349011-kxhpdvri 136 20 reunited reunite VBD cord-349011-kxhpdvri 136 21 at at IN cord-349011-kxhpdvri 136 22 a a DT cord-349011-kxhpdvri 136 23 beer beer NN cord-349011-kxhpdvri 136 24 garden garden NN cord-349011-kxhpdvri 136 25 on on IN cord-349011-kxhpdvri 136 26 Spring Spring NNP cord-349011-kxhpdvri 136 27 Garden Garden NNP cord-349011-kxhpdvri 136 28 Road Road NNP cord-349011-kxhpdvri 136 29 . . . cord-349011-kxhpdvri 137 1 On on IN cord-349011-kxhpdvri 137 2 Friday Friday NNP cord-349011-kxhpdvri 137 3 morning morning NN cord-349011-kxhpdvri 137 4 , , , cord-349011-kxhpdvri 137 5 the the DT cord-349011-kxhpdvri 137 6 first first JJ cord-349011-kxhpdvri 137 7 scientific scientific JJ cord-349011-kxhpdvri 137 8 session session NN cord-349011-kxhpdvri 137 9 focused focus VBN cord-349011-kxhpdvri 137 10 on on IN cord-349011-kxhpdvri 137 11 " " `` cord-349011-kxhpdvri 137 12 Emerging Emerging NNP cord-349011-kxhpdvri 137 13 Methods Methods NNPS cord-349011-kxhpdvri 137 14 in in IN cord-349011-kxhpdvri 137 15 Virology Virology NNP cord-349011-kxhpdvri 137 16 " " '' cord-349011-kxhpdvri 137 17 was be VBD cord-349011-kxhpdvri 137 18 chaired chair VBN cord-349011-kxhpdvri 137 19 by by IN cord-349011-kxhpdvri 137 20 Dr. Dr. NNP cord-349011-kxhpdvri 137 21 Marceline Marceline NNP cord-349011-kxhpdvri 137 22 Côté Côté NNP cord-349011-kxhpdvri 137 23 ( ( -LRB- cord-349011-kxhpdvri 137 24 University University NNP cord-349011-kxhpdvri 137 25 of of IN cord-349011-kxhpdvri 137 26 Ottawa Ottawa NNP cord-349011-kxhpdvri 137 27 ) ) -RRB- cord-349011-kxhpdvri 137 28 and and CC cord-349011-kxhpdvri 137 29 was be VBD cord-349011-kxhpdvri 137 30 led lead VBN cord-349011-kxhpdvri 137 31 off off RP cord-349011-kxhpdvri 137 32 by by IN cord-349011-kxhpdvri 137 33 Dr. Dr. NNP cord-349011-kxhpdvri 137 34 Roger Roger NNP cord-349011-kxhpdvri 137 35 Lippé Lippé NNP cord-349011-kxhpdvri 137 36 ( ( -LRB- cord-349011-kxhpdvri 137 37 Université Université NNP cord-349011-kxhpdvri 137 38 de de NNP cord-349011-kxhpdvri 137 39 Montréal Montréal NNP cord-349011-kxhpdvri 137 40 ) ) -RRB- cord-349011-kxhpdvri 137 41 who who WP cord-349011-kxhpdvri 137 42 described describe VBD cord-349011-kxhpdvri 137 43 a a DT cord-349011-kxhpdvri 137 44 powerful powerful JJ cord-349011-kxhpdvri 137 45 new new JJ cord-349011-kxhpdvri 137 46 technique technique NN cord-349011-kxhpdvri 137 47 called call VBN cord-349011-kxhpdvri 137 48 flow flow NN cord-349011-kxhpdvri 137 49 virometry virometry NN cord-349011-kxhpdvri 137 50 . . . cord-349011-kxhpdvri 138 1 Traditionally traditionally RB cord-349011-kxhpdvri 138 2 , , , cord-349011-kxhpdvri 138 3 flow flow NN cord-349011-kxhpdvri 138 4 cytometry cytometry NN cord-349011-kxhpdvri 138 5 has have VBZ cord-349011-kxhpdvri 138 6 been be VBN cord-349011-kxhpdvri 138 7 a a DT cord-349011-kxhpdvri 138 8 very very RB cord-349011-kxhpdvri 138 9 useful useful JJ cord-349011-kxhpdvri 138 10 approach approach NN cord-349011-kxhpdvri 138 11 to to TO cord-349011-kxhpdvri 138 12 study study VB cord-349011-kxhpdvri 138 13 virus virus NN cord-349011-kxhpdvri 138 14 infection infection NN cord-349011-kxhpdvri 138 15 on on IN cord-349011-kxhpdvri 138 16 a a DT cord-349011-kxhpdvri 138 17 single single JJ cord-349011-kxhpdvri 138 18 - - HYPH cord-349011-kxhpdvri 138 19 cell cell NN cord-349011-kxhpdvri 138 20 basis basis NN cord-349011-kxhpdvri 138 21 , , , cord-349011-kxhpdvri 138 22 but but CC cord-349011-kxhpdvri 138 23 viruses virus NNS cord-349011-kxhpdvri 138 24 themselves -PRON- PRP cord-349011-kxhpdvri 138 25 have have VBP cord-349011-kxhpdvri 138 26 been be VBN cord-349011-kxhpdvri 138 27 too too RB cord-349011-kxhpdvri 138 28 small small JJ cord-349011-kxhpdvri 138 29 to to TO cord-349011-kxhpdvri 138 30 analyze analyze VB cord-349011-kxhpdvri 138 31 due due IN cord-349011-kxhpdvri 138 32 to to IN cord-349011-kxhpdvri 138 33 the the DT cord-349011-kxhpdvri 138 34 0.5 0.5 CD cord-349011-kxhpdvri 138 35 µm µm NN cord-349011-kxhpdvri 138 36 resolution resolution NN cord-349011-kxhpdvri 138 37 of of IN cord-349011-kxhpdvri 138 38 most most JJS cord-349011-kxhpdvri 138 39 instruments instrument NNS cord-349011-kxhpdvri 138 40 . . . cord-349011-kxhpdvri 139 1 Dr. Dr. NNP cord-349011-kxhpdvri 139 2 Lippé Lippé NNP cord-349011-kxhpdvri 139 3 described describe VBD cord-349011-kxhpdvri 139 4 how how WRB cord-349011-kxhpdvri 139 5 his -PRON- PRP$ cord-349011-kxhpdvri 139 6 research research NN cord-349011-kxhpdvri 139 7 group group NN cord-349011-kxhpdvri 139 8 prepares prepare VBZ cord-349011-kxhpdvri 139 9 herpesvirus herpesvirus NN cord-349011-kxhpdvri 139 10 particles particle NNS cord-349011-kxhpdvri 139 11 for for IN cord-349011-kxhpdvri 139 12 analysis analysis NN cord-349011-kxhpdvri 139 13 on on IN cord-349011-kxhpdvri 139 14 these these DT cord-349011-kxhpdvri 139 15 instruments instrument NNS cord-349011-kxhpdvri 139 16 by by IN cord-349011-kxhpdvri 139 17 labelling label VBG cord-349011-kxhpdvri 139 18 with with IN cord-349011-kxhpdvri 139 19 nucleic nucleic JJ cord-349011-kxhpdvri 139 20 acid acid NN cord-349011-kxhpdvri 139 21 dyes dye NNS cord-349011-kxhpdvri 139 22 that that WDT cord-349011-kxhpdvri 139 23 can can MD cord-349011-kxhpdvri 139 24 penetrate penetrate VB cord-349011-kxhpdvri 139 25 viral viral JJ cord-349011-kxhpdvri 139 26 particles particle NNS cord-349011-kxhpdvri 139 27 or or CC cord-349011-kxhpdvri 139 28 engineering engineering NN cord-349011-kxhpdvri 139 29 viral viral JJ cord-349011-kxhpdvri 139 30 particles particle NNS cord-349011-kxhpdvri 139 31 with with IN cord-349011-kxhpdvri 139 32 fluorescent fluorescent JJ cord-349011-kxhpdvri 139 33 fusion fusion NN cord-349011-kxhpdvri 139 34 proteins protein NNS cord-349011-kxhpdvri 139 35 ( ( -LRB- cord-349011-kxhpdvri 139 36 including include VBG cord-349011-kxhpdvri 139 37 capsid capsid NN cord-349011-kxhpdvri 139 38 proteins protein NNS cord-349011-kxhpdvri 139 39 , , , cord-349011-kxhpdvri 139 40 tegument tegument NN cord-349011-kxhpdvri 139 41 proteins protein NNS cord-349011-kxhpdvri 139 42 or or CC cord-349011-kxhpdvri 139 43 glycoproteins glycoprotein NNS cord-349011-kxhpdvri 139 44 ) ) -RRB- cord-349011-kxhpdvri 140 1 [ [ -LRB- cord-349011-kxhpdvri 140 2 34 34 CD cord-349011-kxhpdvri 140 3 ] ] -RRB- cord-349011-kxhpdvri 140 4 [ [ -LRB- cord-349011-kxhpdvri 140 5 35 35 CD cord-349011-kxhpdvri 140 6 ] ] -RRB- cord-349011-kxhpdvri 140 7 [ [ -LRB- cord-349011-kxhpdvri 140 8 36 36 CD cord-349011-kxhpdvri 140 9 ] ] -RRB- cord-349011-kxhpdvri 140 10 . . . cord-349011-kxhpdvri 141 1 This this DT cord-349011-kxhpdvri 141 2 approach approach NN cord-349011-kxhpdvri 141 3 enabled enable VBD cord-349011-kxhpdvri 141 4 characterization characterization NN cord-349011-kxhpdvri 141 5 of of IN cord-349011-kxhpdvri 141 6 individual individual JJ cord-349011-kxhpdvri 141 7 HSV-1 hsv-1 NN cord-349011-kxhpdvri 141 8 particles particle NNS cord-349011-kxhpdvri 141 9 harvested harvest VBN cord-349011-kxhpdvri 141 10 from from IN cord-349011-kxhpdvri 141 11 different different JJ cord-349011-kxhpdvri 141 12 cellular cellular JJ cord-349011-kxhpdvri 141 13 compartments compartment NNS cord-349011-kxhpdvri 141 14 , , , cord-349011-kxhpdvri 141 15 as as RB cord-349011-kxhpdvri 141 16 well well RB cord-349011-kxhpdvri 141 17 as as IN cord-349011-kxhpdvri 141 18 sorting sort VBG cord-349011-kxhpdvri 141 19 to to IN cord-349011-kxhpdvri 141 20 > > $ cord-349011-kxhpdvri 141 21 90 90 CD cord-349011-kxhpdvri 141 22 % % NN cord-349011-kxhpdvri 141 23 purity purity NN cord-349011-kxhpdvri 141 24 . . . cord-349011-kxhpdvri 142 1 Flow flow NN cord-349011-kxhpdvri 142 2 virometry virometry NN cord-349011-kxhpdvri 142 3 also also RB cord-349011-kxhpdvri 142 4 enables enable VBZ cord-349011-kxhpdvri 142 5 the the DT cord-349011-kxhpdvri 142 6 study study NN cord-349011-kxhpdvri 142 7 of of IN cord-349011-kxhpdvri 142 8 the the DT cord-349011-kxhpdvri 142 9 impact impact NN cord-349011-kxhpdvri 142 10 of of IN cord-349011-kxhpdvri 142 11 heterogeneity heterogeneity NN cord-349011-kxhpdvri 142 12 of of IN cord-349011-kxhpdvri 142 13 viral viral JJ cord-349011-kxhpdvri 142 14 populations population NNS cord-349011-kxhpdvri 142 15 on on IN cord-349011-kxhpdvri 142 16 viral viral JJ cord-349011-kxhpdvri 142 17 fitness fitness NN cord-349011-kxhpdvri 142 18 and and CC cord-349011-kxhpdvri 142 19 facilitates facilitate VBZ cord-349011-kxhpdvri 142 20 the the DT cord-349011-kxhpdvri 142 21 analysis analysis NN cord-349011-kxhpdvri 142 22 by by IN cord-349011-kxhpdvri 142 23 mass mass NN cord-349011-kxhpdvri 142 24 spectrometry spectrometry NN cord-349011-kxhpdvri 142 25 of of IN cord-349011-kxhpdvri 142 26 highly highly RB cord-349011-kxhpdvri 142 27 enriched enrich VBN cord-349011-kxhpdvri 142 28 viral viral JJ cord-349011-kxhpdvri 142 29 particles particle NNS cord-349011-kxhpdvri 142 30 isolated isolate VBN cord-349011-kxhpdvri 142 31 along along IN cord-349011-kxhpdvri 142 32 the the DT cord-349011-kxhpdvri 142 33 egress egress NN cord-349011-kxhpdvri 142 34 pathway pathway NN cord-349011-kxhpdvri 142 35 to to TO cord-349011-kxhpdvri 142 36 monitor monitor VB cord-349011-kxhpdvri 142 37 their -PRON- PRP$ cord-349011-kxhpdvri 142 38 maturation maturation NN cord-349011-kxhpdvri 142 39 . . . cord-349011-kxhpdvri 143 1 Because because IN cord-349011-kxhpdvri 143 2 flow flow NN cord-349011-kxhpdvri 143 3 virometry virometry NN cord-349011-kxhpdvri 143 4 can can MD cord-349011-kxhpdvri 143 5 be be VB cord-349011-kxhpdvri 143 6 performed perform VBN cord-349011-kxhpdvri 143 7 on on IN cord-349011-kxhpdvri 143 8 standard standard JJ cord-349011-kxhpdvri 143 9 flow flow NN cord-349011-kxhpdvri 143 10 cytometers cytometer NNS cord-349011-kxhpdvri 143 11 and and CC cord-349011-kxhpdvri 143 12 flow flow NN cord-349011-kxhpdvri 143 13 sorters sorter NNS cord-349011-kxhpdvri 143 14 available available JJ cord-349011-kxhpdvri 143 15 at at IN cord-349011-kxhpdvri 143 16 most most JJS cord-349011-kxhpdvri 143 17 institutions institution NNS cord-349011-kxhpdvri 143 18 , , , cord-349011-kxhpdvri 143 19 these these DT cord-349011-kxhpdvri 143 20 approaches approach NNS cord-349011-kxhpdvri 143 21 can can MD cord-349011-kxhpdvri 143 22 be be VB cord-349011-kxhpdvri 143 23 rapidly rapidly RB cord-349011-kxhpdvri 143 24 adopted adopt VBN cord-349011-kxhpdvri 143 25 by by IN cord-349011-kxhpdvri 143 26 others other NNS cord-349011-kxhpdvri 143 27 and and CC cord-349011-kxhpdvri 143 28 applied apply VBD cord-349011-kxhpdvri 143 29 to to IN cord-349011-kxhpdvri 143 30 the the DT cord-349011-kxhpdvri 143 31 study study NN cord-349011-kxhpdvri 143 32 of of IN cord-349011-kxhpdvri 143 33 other other JJ cord-349011-kxhpdvri 143 34 large large JJ cord-349011-kxhpdvri 143 35 viruses virus NNS cord-349011-kxhpdvri 143 36 . . . cord-349011-kxhpdvri 144 1 Low low JJ cord-349011-kxhpdvri 144 2 - - HYPH cord-349011-kxhpdvri 144 3 cost cost NN cord-349011-kxhpdvri 144 4 DNA dna NN cord-349011-kxhpdvri 144 5 synthesis synthesis NN cord-349011-kxhpdvri 144 6 has have VBZ cord-349011-kxhpdvri 144 7 catalyzed catalyze VBN cord-349011-kxhpdvri 144 8 a a DT cord-349011-kxhpdvri 144 9 new new JJ cord-349011-kxhpdvri 144 10 revolution revolution NN cord-349011-kxhpdvri 144 11 in in IN cord-349011-kxhpdvri 144 12 synthetic synthetic JJ cord-349011-kxhpdvri 144 13 biology biology NN cord-349011-kxhpdvri 144 14 , , , cord-349011-kxhpdvri 144 15 enabling enable VBG cord-349011-kxhpdvri 144 16 efficient efficient JJ cord-349011-kxhpdvri 144 17 manipulation manipulation NN cord-349011-kxhpdvri 144 18 and and CC cord-349011-kxhpdvri 144 19 re re NN cord-349011-kxhpdvri 144 20 - - NN cord-349011-kxhpdvri 144 21 coding coding NN cord-349011-kxhpdvri 144 22 of of IN cord-349011-kxhpdvri 144 23 microbial microbial JJ cord-349011-kxhpdvri 144 24 and and CC cord-349011-kxhpdvri 144 25 eukaryotic eukaryotic JJ cord-349011-kxhpdvri 144 26 genomes genome NNS cord-349011-kxhpdvri 144 27 . . . cord-349011-kxhpdvri 145 1 Ryan Ryan NNP cord-349011-kxhpdvri 145 2 Noyce Noyce NNP cord-349011-kxhpdvri 145 3 ( ( -LRB- cord-349011-kxhpdvri 145 4 University University NNP cord-349011-kxhpdvri 145 5 of of IN cord-349011-kxhpdvri 145 6 Alberta Alberta NNP cord-349011-kxhpdvri 145 7 ) ) -RRB- cord-349011-kxhpdvri 145 8 described describe VBD cord-349011-kxhpdvri 145 9 his -PRON- PRP$ cord-349011-kxhpdvri 145 10 efforts effort NNS cord-349011-kxhpdvri 145 11 to to TO cord-349011-kxhpdvri 145 12 use use VB cord-349011-kxhpdvri 145 13 the the DT cord-349011-kxhpdvri 145 14 principles principle NNS cord-349011-kxhpdvri 145 15 of of IN cord-349011-kxhpdvri 145 16 synthetic synthetic JJ cord-349011-kxhpdvri 145 17 biology biology NN cord-349011-kxhpdvri 145 18 to to TO cord-349011-kxhpdvri 145 19 create create VB cord-349011-kxhpdvri 145 20 a a DT cord-349011-kxhpdvri 145 21 synthetic synthetic JJ cord-349011-kxhpdvri 145 22 poxvirus poxvirus JJ cord-349011-kxhpdvri 145 23 vector vector NN cord-349011-kxhpdvri 145 24 that that WDT cord-349011-kxhpdvri 145 25 could could MD cord-349011-kxhpdvri 145 26 be be VB cord-349011-kxhpdvri 145 27 used use VBN cord-349011-kxhpdvri 145 28 for for IN cord-349011-kxhpdvri 145 29 a a DT cord-349011-kxhpdvri 145 30 variety variety NN cord-349011-kxhpdvri 145 31 of of IN cord-349011-kxhpdvri 145 32 therapeutic therapeutic JJ cord-349011-kxhpdvri 145 33 applications application NNS cord-349011-kxhpdvri 145 34 . . . cord-349011-kxhpdvri 146 1 Edward Edward NNP cord-349011-kxhpdvri 146 2 Jenner Jenner NNP cord-349011-kxhpdvri 146 3 believed believe VBD cord-349011-kxhpdvri 146 4 that that IN cord-349011-kxhpdvri 146 5 his -PRON- PRP$ cord-349011-kxhpdvri 146 6 variolae variolae NNP cord-349011-kxhpdvri 146 7 vaccinae vaccinae NNP cord-349011-kxhpdvri 146 8 originated originate VBD cord-349011-kxhpdvri 146 9 in in IN cord-349011-kxhpdvri 146 10 horses horse NNS cord-349011-kxhpdvri 146 11 , , , cord-349011-kxhpdvri 146 12 which which WDT cord-349011-kxhpdvri 146 13 has have VBZ cord-349011-kxhpdvri 146 14 been be VBN cord-349011-kxhpdvri 146 15 corroborated corroborate VBN cord-349011-kxhpdvri 146 16 by by IN cord-349011-kxhpdvri 146 17 molecular molecular JJ cord-349011-kxhpdvri 146 18 analyses analysis NNS cord-349011-kxhpdvri 146 19 of of IN cord-349011-kxhpdvri 146 20 modern modern JJ cord-349011-kxhpdvri 146 21 vaccinia vaccinia NN cord-349011-kxhpdvri 146 22 virus virus NN cord-349011-kxhpdvri 146 23 ( ( -LRB- cord-349011-kxhpdvri 146 24 VACV VACV NNP cord-349011-kxhpdvri 146 25 ) ) -RRB- cord-349011-kxhpdvri 146 26 isolates isolate VBZ cord-349011-kxhpdvri 146 27 that that WDT cord-349011-kxhpdvri 146 28 share share VBP cord-349011-kxhpdvri 146 29 common common JJ cord-349011-kxhpdvri 146 30 ancestry ancestry NN cord-349011-kxhpdvri 146 31 with with IN cord-349011-kxhpdvri 146 32 horsepox horsepox NNP cord-349011-kxhpdvri 146 33 virus virus NN cord-349011-kxhpdvri 146 34 ( ( -LRB- cord-349011-kxhpdvri 146 35 HPXV HPXV NNP cord-349011-kxhpdvri 146 36 ) ) -RRB- cord-349011-kxhpdvri 147 1 [ [ -LRB- cord-349011-kxhpdvri 147 2 37 37 CD cord-349011-kxhpdvri 147 3 ] ] -RRB- cord-349011-kxhpdvri 147 4 [ [ -LRB- cord-349011-kxhpdvri 147 5 38 38 CD cord-349011-kxhpdvri 147 6 ] ] -RRB- cord-349011-kxhpdvri 148 1 [ [ -LRB- cord-349011-kxhpdvri 148 2 39 39 CD cord-349011-kxhpdvri 148 3 ] ] -RRB- cord-349011-kxhpdvri 148 4 ( ( -LRB- cord-349011-kxhpdvri 148 5 incidentally incidentally RB cord-349011-kxhpdvri 148 6 , , , cord-349011-kxhpdvri 148 7 Dr. Dr. NNP cord-349011-kxhpdvri 148 8 Noyce Noyce NNP cord-349011-kxhpdvri 148 9 told tell VBD cord-349011-kxhpdvri 148 10 us -PRON- PRP cord-349011-kxhpdvri 148 11 , , , cord-349011-kxhpdvri 148 12 this this DT cord-349011-kxhpdvri 148 13 means mean VBZ cord-349011-kxhpdvri 148 14 that that IN cord-349011-kxhpdvri 148 15 the the DT cord-349011-kxhpdvri 148 16 term term NN cord-349011-kxhpdvri 148 17 " " `` cord-349011-kxhpdvri 148 18 vaccination vaccination NN cord-349011-kxhpdvri 148 19 " " '' cord-349011-kxhpdvri 148 20 could could MD cord-349011-kxhpdvri 148 21 be be VB cord-349011-kxhpdvri 148 22 a a DT cord-349011-kxhpdvri 148 23 misnomer misnomer NN cord-349011-kxhpdvri 148 24 ; ; : cord-349011-kxhpdvri 148 25 cows cow NNS cord-349011-kxhpdvri 148 26 may may MD cord-349011-kxhpdvri 148 27 have have VB cord-349011-kxhpdvri 148 28 had have VBD cord-349011-kxhpdvri 148 29 nothing nothing NN cord-349011-kxhpdvri 148 30 to to TO cord-349011-kxhpdvri 148 31 do do VB cord-349011-kxhpdvri 148 32 with with IN cord-349011-kxhpdvri 148 33 it -PRON- PRP cord-349011-kxhpdvri 148 34 , , , cord-349011-kxhpdvri 148 35 and and CC cord-349011-kxhpdvri 148 36 the the DT cord-349011-kxhpdvri 148 37 term term NN cord-349011-kxhpdvri 148 38 " " `` cord-349011-kxhpdvri 148 39 equination equination NN cord-349011-kxhpdvri 148 40 " " '' cord-349011-kxhpdvri 148 41 may may MD cord-349011-kxhpdvri 148 42 be be VB cord-349011-kxhpdvri 148 43 more more RBR cord-349011-kxhpdvri 148 44 accurate accurate JJ cord-349011-kxhpdvri 148 45 [ [ -LRB- cord-349011-kxhpdvri 148 46 40 40 CD cord-349011-kxhpdvri 148 47 ] ] -RRB- cord-349011-kxhpdvri 148 48 ) ) -RRB- cord-349011-kxhpdvri 148 49 . . . cord-349011-kxhpdvri 149 1 To to TO cord-349011-kxhpdvri 149 2 improve improve VB cord-349011-kxhpdvri 149 3 on on IN cord-349011-kxhpdvri 149 4 the the DT cord-349011-kxhpdvri 149 5 safety safety NN cord-349011-kxhpdvri 149 6 and and CC cord-349011-kxhpdvri 149 7 efficacy efficacy NN cord-349011-kxhpdvri 149 8 of of IN cord-349011-kxhpdvri 149 9 VACV VACV NNP cord-349011-kxhpdvri 149 10 , , , cord-349011-kxhpdvri 149 11 Dr. Dr. NNP cord-349011-kxhpdvri 149 12 Noyce Noyce NNP cord-349011-kxhpdvri 149 13 and and CC cord-349011-kxhpdvri 149 14 colleagues colleague NNS cord-349011-kxhpdvri 149 15 chose choose VBD cord-349011-kxhpdvri 149 16 to to TO cord-349011-kxhpdvri 149 17 reactivate reactivate VB cord-349011-kxhpdvri 149 18 the the DT cord-349011-kxhpdvri 149 19 ancestral ancestral JJ cord-349011-kxhpdvri 149 20 HPXV hpxv NN cord-349011-kxhpdvri 149 21 and and CC cord-349011-kxhpdvri 149 22 use use VB cord-349011-kxhpdvri 149 23 it -PRON- PRP cord-349011-kxhpdvri 149 24 as as IN cord-349011-kxhpdvri 149 25 a a DT cord-349011-kxhpdvri 149 26 template template NN cord-349011-kxhpdvri 149 27 for for IN cord-349011-kxhpdvri 149 28 safer safe JJR cord-349011-kxhpdvri 149 29 and and CC cord-349011-kxhpdvri 149 30 more more RBR cord-349011-kxhpdvri 149 31 efficacious efficacious JJ cord-349011-kxhpdvri 149 32 vaccines vaccine NNS cord-349011-kxhpdvri 149 33 and and CC cord-349011-kxhpdvri 149 34 other other JJ cord-349011-kxhpdvri 149 35 therapeutics therapeutic NNS cord-349011-kxhpdvri 149 36 including include VBG cord-349011-kxhpdvri 149 37 oncolytic oncolytic JJ cord-349011-kxhpdvri 149 38 viruses virus NNS cord-349011-kxhpdvri 149 39 . . . cord-349011-kxhpdvri 150 1 Dr. Dr. NNP cord-349011-kxhpdvri 150 2 Noyce Noyce NNP cord-349011-kxhpdvri 150 3 synthesized synthesize VBD cord-349011-kxhpdvri 150 4 ten ten CD cord-349011-kxhpdvri 150 5 large large JJ cord-349011-kxhpdvri 150 6 ( ( -LRB- cord-349011-kxhpdvri 150 7 10 10 CD cord-349011-kxhpdvri 150 8 - - SYM cord-349011-kxhpdvri 150 9 30 30 CD cord-349011-kxhpdvri 150 10 kilobase kilobase NN cord-349011-kxhpdvri 150 11 pair pair NN cord-349011-kxhpdvri 150 12 ) ) -RRB- cord-349011-kxhpdvri 150 13 fragments fragment NNS cord-349011-kxhpdvri 150 14 of of IN cord-349011-kxhpdvri 150 15 DNA dna NN cord-349011-kxhpdvri 150 16 based base VBN cord-349011-kxhpdvri 150 17 on on IN cord-349011-kxhpdvri 150 18 the the DT cord-349011-kxhpdvri 150 19 published publish VBN cord-349011-kxhpdvri 150 20 HPXV HPXV NNP cord-349011-kxhpdvri 150 21 sequence sequence NN cord-349011-kxhpdvri 150 22 [ [ -LRB- cord-349011-kxhpdvri 150 23 38 38 CD cord-349011-kxhpdvri 150 24 ] ] -RRB- cord-349011-kxhpdvri 150 25 , , , cord-349011-kxhpdvri 150 26 along along IN cord-349011-kxhpdvri 150 27 with with IN cord-349011-kxhpdvri 150 28 VACV VACV NNP cord-349011-kxhpdvri 150 29 - - HYPH cord-349011-kxhpdvri 150 30 derived derive VBN cord-349011-kxhpdvri 150 31 terminal terminal NN cord-349011-kxhpdvri 150 32 sequences sequence NNS cord-349011-kxhpdvri 150 33 [ [ -LRB- cord-349011-kxhpdvri 150 34 41 41 CD cord-349011-kxhpdvri 150 35 ] ] -RRB- cord-349011-kxhpdvri 150 36 . . . cord-349011-kxhpdvri 151 1 These these DT cord-349011-kxhpdvri 151 2 sequences sequence NNS cord-349011-kxhpdvri 151 3 were be VBD cord-349011-kxhpdvri 151 4 recombined recombine VBN cord-349011-kxhpdvri 151 5 into into IN cord-349011-kxhpdvri 151 6 a a DT cord-349011-kxhpdvri 151 7 212 212 CD cord-349011-kxhpdvri 151 8 kilobase kilobase NNP cord-349011-kxhpdvri 151 9 pair pair NN cord-349011-kxhpdvri 151 10 live live RB cord-349011-kxhpdvri 151 11 synthetic synthetic JJ cord-349011-kxhpdvri 151 12 chimeric chimeric JJ cord-349011-kxhpdvri 151 13 ( ( -LRB- cord-349011-kxhpdvri 151 14 scHPXV scHPXV NNP cord-349011-kxhpdvri 151 15 ) ) -RRB- cord-349011-kxhpdvri 151 16 virus virus NN cord-349011-kxhpdvri 151 17 in in IN cord-349011-kxhpdvri 151 18 cells cell NNS cord-349011-kxhpdvri 151 19 infected infect VBN cord-349011-kxhpdvri 151 20 with with IN cord-349011-kxhpdvri 151 21 Shope Shope NNP cord-349011-kxhpdvri 151 22 fibroma fibroma NN cord-349011-kxhpdvri 151 23 virus virus NN cord-349011-kxhpdvri 151 24 ( ( -LRB- cord-349011-kxhpdvri 151 25 SFV SFV NNP cord-349011-kxhpdvri 151 26 ) ) -RRB- cord-349011-kxhpdvri 151 27 , , , cord-349011-kxhpdvri 151 28 which which WDT cord-349011-kxhpdvri 151 29 served serve VBD cord-349011-kxhpdvri 151 30 as as IN cord-349011-kxhpdvri 151 31 a a DT cord-349011-kxhpdvri 151 32 helper helper NN cord-349011-kxhpdvri 151 33 virus virus NN cord-349011-kxhpdvri 151 34 . . . cord-349011-kxhpdvri 152 1 scHPXV scHPXV NNP cord-349011-kxhpdvri 152 2 was be VBD cord-349011-kxhpdvri 152 3 safe safe JJ cord-349011-kxhpdvri 152 4 and and CC cord-349011-kxhpdvri 152 5 effective effective JJ cord-349011-kxhpdvri 152 6 in in IN cord-349011-kxhpdvri 152 7 pre pre JJ cord-349011-kxhpdvri 152 8 - - JJ cord-349011-kxhpdvri 152 9 clinical clinical JJ cord-349011-kxhpdvri 152 10 studies study NNS cord-349011-kxhpdvri 152 11 ; ; : cord-349011-kxhpdvri 152 12 it -PRON- PRP cord-349011-kxhpdvri 152 13 produced produce VBD cord-349011-kxhpdvri 152 14 smaller small JJR cord-349011-kxhpdvri 152 15 plaques plaque NNS cord-349011-kxhpdvri 152 16 in in IN cord-349011-kxhpdvri 152 17 cell cell NN cord-349011-kxhpdvri 152 18 culture culture NN cord-349011-kxhpdvri 152 19 and and CC cord-349011-kxhpdvri 152 20 was be VBD cord-349011-kxhpdvri 152 21 less less RBR cord-349011-kxhpdvri 152 22 virulent virulent JJ cord-349011-kxhpdvri 152 23 in in IN cord-349011-kxhpdvri 152 24 mice mouse NNS cord-349011-kxhpdvri 152 25 than than IN cord-349011-kxhpdvri 152 26 VACV VACV NNP cord-349011-kxhpdvri 152 27 , , , cord-349011-kxhpdvri 152 28 but but CC cord-349011-kxhpdvri 152 29 still still RB cord-349011-kxhpdvri 152 30 provided provide VBD cord-349011-kxhpdvri 152 31 protection protection NN cord-349011-kxhpdvri 152 32 against against IN cord-349011-kxhpdvri 152 33 a a DT cord-349011-kxhpdvri 152 34 lethal lethal JJ cord-349011-kxhpdvri 152 35 VACV VACV NNP cord-349011-kxhpdvri 152 36 challenge challenge NN cord-349011-kxhpdvri 152 37 . . . cord-349011-kxhpdvri 153 1 Dr. Dr. NNP cord-349011-kxhpdvri 153 2 Noyce Noyce NNP cord-349011-kxhpdvri 153 3 discussed discuss VBD cord-349011-kxhpdvri 153 4 the the DT cord-349011-kxhpdvri 153 5 technical technical JJ cord-349011-kxhpdvri 153 6 challenges challenge NNS cord-349011-kxhpdvri 153 7 associated associate VBN cord-349011-kxhpdvri 153 8 with with IN cord-349011-kxhpdvri 153 9 using use VBG cord-349011-kxhpdvri 153 10 synthetic synthetic JJ cord-349011-kxhpdvri 153 11 biology biology NN cord-349011-kxhpdvri 153 12 as as IN cord-349011-kxhpdvri 153 13 a a DT cord-349011-kxhpdvri 153 14 tool tool NN cord-349011-kxhpdvri 153 15 to to TO cord-349011-kxhpdvri 153 16 build build VB cord-349011-kxhpdvri 153 17 new new JJ cord-349011-kxhpdvri 153 18 viruses virus NNS cord-349011-kxhpdvri 153 19 , , , cord-349011-kxhpdvri 153 20 as as RB cord-349011-kxhpdvri 153 21 well well RB cord-349011-kxhpdvri 153 22 as as IN cord-349011-kxhpdvri 153 23 biosafety biosafety NN cord-349011-kxhpdvri 153 24 and and CC cord-349011-kxhpdvri 153 25 ethical ethical JJ cord-349011-kxhpdvri 153 26 considerations consideration NNS cord-349011-kxhpdvri 153 27 . . . cord-349011-kxhpdvri 154 1 The the DT cord-349011-kxhpdvri 154 2 " " `` cord-349011-kxhpdvri 154 3 Emerging Emerging NNP cord-349011-kxhpdvri 154 4 Methods Methods NNPS cord-349011-kxhpdvri 154 5 in in IN cord-349011-kxhpdvri 154 6 Virology Virology NNP cord-349011-kxhpdvri 154 7 " " '' cord-349011-kxhpdvri 154 8 session session NN cord-349011-kxhpdvri 154 9 also also RB cord-349011-kxhpdvri 154 10 included include VBD cord-349011-kxhpdvri 154 11 presentations presentation NNS cord-349011-kxhpdvri 154 12 from from IN cord-349011-kxhpdvri 154 13 the the DT cord-349011-kxhpdvri 154 14 following follow VBG cord-349011-kxhpdvri 154 15 trainees trainee NNS cord-349011-kxhpdvri 154 16 : : : cord-349011-kxhpdvri 155 1 Vanessa Vanessa NNP cord-349011-kxhpdvri 155 2 Meier Meier NNP cord-349011-kxhpdvri 155 3 - - HYPH cord-349011-kxhpdvri 155 4 Stephenson Stephenson NNP cord-349011-kxhpdvri 155 5 ( ( -LRB- cord-349011-kxhpdvri 155 6 University University NNP cord-349011-kxhpdvri 155 7 of of IN cord-349011-kxhpdvri 155 8 Calgary Calgary NNP cord-349011-kxhpdvri 155 9 and and CC cord-349011-kxhpdvri 155 10 University University NNP cord-349011-kxhpdvri 155 11 of of IN cord-349011-kxhpdvri 155 12 Lethbridge Lethbridge NNP cord-349011-kxhpdvri 155 13 ) ) -RRB- cord-349011-kxhpdvri 155 14 who who WP cord-349011-kxhpdvri 155 15 presented present VBD cord-349011-kxhpdvri 155 16 her -PRON- PRP$ cord-349011-kxhpdvri 155 17 findings finding NNS cord-349011-kxhpdvri 155 18 of of IN cord-349011-kxhpdvri 155 19 complex complex JJ cord-349011-kxhpdvri 155 20 DNA dna NN cord-349011-kxhpdvri 155 21 structures structure NNS cord-349011-kxhpdvri 155 22 in in IN cord-349011-kxhpdvri 155 23 the the DT cord-349011-kxhpdvri 155 24 hepatitis hepatitis NN cord-349011-kxhpdvri 155 25 B B NNP cord-349011-kxhpdvri 155 26 virus virus NN cord-349011-kxhpdvri 155 27 ( ( -LRB- cord-349011-kxhpdvri 155 28 HBV HBV NNP cord-349011-kxhpdvri 155 29 ) ) -RRB- cord-349011-kxhpdvri 155 30 genome genome NN cord-349011-kxhpdvri 155 31 , , , cord-349011-kxhpdvri 155 32 Yumiko Yumiko NNP cord-349011-kxhpdvri 155 33 Komatsu Komatsu NNP cord-349011-kxhpdvri 155 34 ( ( -LRB- cord-349011-kxhpdvri 155 35 Kyoto Kyoto NNP cord-349011-kxhpdvri 155 36 University University NNP cord-349011-kxhpdvri 155 37 ) ) -RRB- cord-349011-kxhpdvri 155 38 who who WP cord-349011-kxhpdvri 155 39 presented present VBD cord-349011-kxhpdvri 155 40 her -PRON- PRP$ cord-349011-kxhpdvri 155 41 research research NN cord-349011-kxhpdvri 155 42 on on IN cord-349011-kxhpdvri 155 43 Borna Borna NNP cord-349011-kxhpdvri 155 44 disease disease NN cord-349011-kxhpdvri 155 45 virus virus NN cord-349011-kxhpdvri 155 46 vectors vector NNS cord-349011-kxhpdvri 155 47 , , , cord-349011-kxhpdvri 155 48 and and CC cord-349011-kxhpdvri 155 49 Brennan Brennan NNP cord-349011-kxhpdvri 155 50 Dirk Dirk NNP cord-349011-kxhpdvri 155 51 ( ( -LRB- cord-349011-kxhpdvri 155 52 Western Western NNP cord-349011-kxhpdvri 155 53 University University NNP cord-349011-kxhpdvri 155 54 ) ) -RRB- cord-349011-kxhpdvri 155 55 who who WP cord-349011-kxhpdvri 155 56 discussed discuss VBD cord-349011-kxhpdvri 155 57 his -PRON- PRP$ cord-349011-kxhpdvri 155 58 efforts effort NNS cord-349011-kxhpdvri 155 59 to to TO cord-349011-kxhpdvri 155 60 trace trace VB cord-349011-kxhpdvri 155 61 multiprotein multiprotein NNP cord-349011-kxhpdvri 155 62 complexes complex NNS cord-349011-kxhpdvri 155 63 involved involve VBN cord-349011-kxhpdvri 155 64 in in IN cord-349011-kxhpdvri 155 65 HIV-1 HIV-1 NNP cord-349011-kxhpdvri 155 66 immune immune JJ cord-349011-kxhpdvri 155 67 evasion evasion NN cord-349011-kxhpdvri 155 68 [ [ -LRB- cord-349011-kxhpdvri 155 69 42 42 CD cord-349011-kxhpdvri 155 70 , , , cord-349011-kxhpdvri 155 71 43 43 CD cord-349011-kxhpdvri 155 72 ] ] -RRB- cord-349011-kxhpdvri 155 73 . . . cord-349011-kxhpdvri 156 1 Dr. Dr. NNP cord-349011-kxhpdvri 156 2 Andrew Andrew NNP cord-349011-kxhpdvri 156 3 White White NNP cord-349011-kxhpdvri 156 4 ( ( -LRB- cord-349011-kxhpdvri 156 5 York York NNP cord-349011-kxhpdvri 156 6 University University NNP cord-349011-kxhpdvri 156 7 ) ) -RRB- cord-349011-kxhpdvri 156 8 chaired chair VBD cord-349011-kxhpdvri 156 9 the the DT cord-349011-kxhpdvri 156 10 next next JJ cord-349011-kxhpdvri 156 11 session session NN cord-349011-kxhpdvri 156 12 on on IN cord-349011-kxhpdvri 156 13 " " `` cord-349011-kxhpdvri 156 14 RNA RNA NNP cord-349011-kxhpdvri 156 15 in in IN cord-349011-kxhpdvri 156 16 Virus Virus NNP cord-349011-kxhpdvri 156 17 Infection Infection NNP cord-349011-kxhpdvri 156 18 " " '' cord-349011-kxhpdvri 156 19 , , , cord-349011-kxhpdvri 156 20 which which WDT cord-349011-kxhpdvri 156 21 opened open VBD cord-349011-kxhpdvri 156 22 with with IN cord-349011-kxhpdvri 156 23 a a DT cord-349011-kxhpdvri 156 24 talk talk NN cord-349011-kxhpdvri 156 25 from from IN cord-349011-kxhpdvri 156 26 Dr. Dr. NNP cord-349011-kxhpdvri 156 27 Selena Selena NNP cord-349011-kxhpdvri 156 28 Sagan Sagan NNP cord-349011-kxhpdvri 156 29 ( ( -LRB- cord-349011-kxhpdvri 156 30 McGill McGill NNP cord-349011-kxhpdvri 156 31 University University NNP cord-349011-kxhpdvri 156 32 ) ) -RRB- cord-349011-kxhpdvri 156 33 . . . cord-349011-kxhpdvri 157 1 The the DT cord-349011-kxhpdvri 157 2 liver liver NN cord-349011-kxhpdvri 157 3 - - HYPH cord-349011-kxhpdvri 157 4 specific specific JJ cord-349011-kxhpdvri 157 5 microRNA-122 microRNA-122 NNP cord-349011-kxhpdvri 157 6 ( ( -LRB- cord-349011-kxhpdvri 157 7 miR-122 miR-122 NNP cord-349011-kxhpdvri 157 8 ) ) -RRB- cord-349011-kxhpdvri 157 9 directly directly RB cord-349011-kxhpdvri 157 10 binds bind VBZ cord-349011-kxhpdvri 157 11 to to IN cord-349011-kxhpdvri 157 12 the the DT cord-349011-kxhpdvri 157 13 5'-end 5'-end CD cord-349011-kxhpdvri 157 14 of of IN cord-349011-kxhpdvri 157 15 the the DT cord-349011-kxhpdvri 157 16 hepatitis hepatitis NN cord-349011-kxhpdvri 157 17 C C NNP cord-349011-kxhpdvri 157 18 virus virus NN cord-349011-kxhpdvri 157 19 ( ( -LRB- cord-349011-kxhpdvri 157 20 HCV HCV NNP cord-349011-kxhpdvri 157 21 ) ) -RRB- cord-349011-kxhpdvri 157 22 genome genome NN cord-349011-kxhpdvri 157 23 and and CC cord-349011-kxhpdvri 157 24 promotes promote VBZ cord-349011-kxhpdvri 157 25 the the DT cord-349011-kxhpdvri 157 26 accumulation accumulation NN cord-349011-kxhpdvri 157 27 of of IN cord-349011-kxhpdvri 157 28 viral viral JJ cord-349011-kxhpdvri 157 29 RNA RNA NNP cord-349011-kxhpdvri 157 30 in in IN cord-349011-kxhpdvri 157 31 cell cell NN cord-349011-kxhpdvri 157 32 culture culture NN cord-349011-kxhpdvri 157 33 and and CC cord-349011-kxhpdvri 157 34 animal animal NN cord-349011-kxhpdvri 157 35 models model NNS cord-349011-kxhpdvri 157 36 , , , cord-349011-kxhpdvri 157 37 at at IN cord-349011-kxhpdvri 157 38 least least JJS cord-349011-kxhpdvri 157 39 in in IN cord-349011-kxhpdvri 157 40 part part NN cord-349011-kxhpdvri 157 41 by by IN cord-349011-kxhpdvri 157 42 protecting protect VBG cord-349011-kxhpdvri 157 43 the the DT cord-349011-kxhpdvri 157 44 genome genome NN cord-349011-kxhpdvri 157 45 from from IN cord-349011-kxhpdvri 157 46 degradation degradation NN cord-349011-kxhpdvri 157 47 by by IN cord-349011-kxhpdvri 157 48 the the DT cord-349011-kxhpdvri 157 49 host host NN cord-349011-kxhpdvri 157 50 5'-3 5'-3 CD cord-349011-kxhpdvri 157 51 ' ' POS cord-349011-kxhpdvri 157 52 exonucleases exonuclease NNS cord-349011-kxhpdvri 158 1 Xrn1 Xrn1 NNP cord-349011-kxhpdvri 158 2 and and CC cord-349011-kxhpdvri 158 3 Xrn2 Xrn2 NNP cord-349011-kxhpdvri 158 4 . . . cord-349011-kxhpdvri 159 1 Because because IN cord-349011-kxhpdvri 159 2 the the DT cord-349011-kxhpdvri 159 3 HCV HCV NNP cord-349011-kxhpdvri 159 4 5'-triphosphate 5'-triphosphate NNP cord-349011-kxhpdvri 159 5 structure structure NN cord-349011-kxhpdvri 159 6 is be VBZ cord-349011-kxhpdvri 159 7 a a DT cord-349011-kxhpdvri 159 8 molecular molecular JJ cord-349011-kxhpdvri 159 9 pattern pattern NN cord-349011-kxhpdvri 159 10 expected expect VBN cord-349011-kxhpdvri 159 11 to to TO cord-349011-kxhpdvri 159 12 be be VB cord-349011-kxhpdvri 159 13 recognized recognize VBN cord-349011-kxhpdvri 159 14 by by IN cord-349011-kxhpdvri 159 15 pattern pattern NN cord-349011-kxhpdvri 159 16 recognition recognition NN cord-349011-kxhpdvri 159 17 receptors receptor NNS cord-349011-kxhpdvri 159 18 ( ( -LRB- cord-349011-kxhpdvri 159 19 PRRs PRRs NNP cord-349011-kxhpdvri 159 20 ) ) -RRB- cord-349011-kxhpdvri 159 21 , , , cord-349011-kxhpdvri 159 22 the the DT cord-349011-kxhpdvri 159 23 Sagan Sagan NNP cord-349011-kxhpdvri 159 24 ( ( -LRB- cord-349011-kxhpdvri 159 25 McGill McGill NNP cord-349011-kxhpdvri 159 26 University University NNP cord-349011-kxhpdvri 159 27 ) ) -RRB- cord-349011-kxhpdvri 159 28 and and CC cord-349011-kxhpdvri 159 29 Wilson Wilson NNP cord-349011-kxhpdvri 159 30 ( ( -LRB- cord-349011-kxhpdvri 159 31 University University NNP cord-349011-kxhpdvri 159 32 of of IN cord-349011-kxhpdvri 159 33 Saskatchewan Saskatchewan NNP cord-349011-kxhpdvri 159 34 ) ) -RRB- cord-349011-kxhpdvri 159 35 groups group NNS cord-349011-kxhpdvri 159 36 investigated investigate VBD cord-349011-kxhpdvri 159 37 whether whether IN cord-349011-kxhpdvri 159 38 miR-122 miR-122 NNP cord-349011-kxhpdvri 159 39 binding bind VBG cord-349011-kxhpdvri 159 40 to to IN cord-349011-kxhpdvri 159 41 the the DT cord-349011-kxhpdvri 159 42 HCV HCV NNP cord-349011-kxhpdvri 159 43 genome genome NN cord-349011-kxhpdvri 159 44 affects affect VBZ cord-349011-kxhpdvri 159 45 PRR PRR NNP cord-349011-kxhpdvri 159 46 binding binding NN cord-349011-kxhpdvri 159 47 and and CC cord-349011-kxhpdvri 159 48 activation activation NN cord-349011-kxhpdvri 159 49 of of IN cord-349011-kxhpdvri 159 50 innate innate JJ cord-349011-kxhpdvri 159 51 antiviral antiviral JJ cord-349011-kxhpdvri 159 52 signaling signal VBG cord-349011-kxhpdvri 159 53 pathways pathway NNS cord-349011-kxhpdvri 159 54 . . . cord-349011-kxhpdvri 160 1 Dr. Dr. NNP cord-349011-kxhpdvri 160 2 Sagan Sagan NNP cord-349011-kxhpdvri 160 3 reported report VBD cord-349011-kxhpdvri 160 4 that that IN cord-349011-kxhpdvri 160 5 miR-122 miR-122 NNP cord-349011-kxhpdvri 160 6 does do VBZ cord-349011-kxhpdvri 160 7 not not RB cord-349011-kxhpdvri 160 8 affect affect VB cord-349011-kxhpdvri 160 9 recognition recognition NN cord-349011-kxhpdvri 160 10 of of IN cord-349011-kxhpdvri 160 11 the the DT cord-349011-kxhpdvri 160 12 HCV HCV NNP cord-349011-kxhpdvri 160 13 genome genome NN cord-349011-kxhpdvri 160 14 by by IN cord-349011-kxhpdvri 160 15 protein protein NN cord-349011-kxhpdvri 160 16 kinase kinase NN cord-349011-kxhpdvri 160 17 R r NN cord-349011-kxhpdvri 160 18 ( ( -LRB- cord-349011-kxhpdvri 160 19 PKR PKR NNP cord-349011-kxhpdvri 160 20 ) ) -RRB- cord-349011-kxhpdvri 160 21 , , , cord-349011-kxhpdvri 160 22 retinoic retinoic JJ cord-349011-kxhpdvri 160 23 acid acid NN cord-349011-kxhpdvri 160 24 inducible inducible JJ cord-349011-kxhpdvri 160 25 protein protein NN cord-349011-kxhpdvri 160 26 I i NN cord-349011-kxhpdvri 160 27 ( ( -LRB- cord-349011-kxhpdvri 160 28 RIG RIG NNP cord-349011-kxhpdvri 160 29 - - HYPH cord-349011-kxhpdvri 160 30 I)-like I)-like NNP cord-349011-kxhpdvri 160 31 receptors receptor NNS cord-349011-kxhpdvri 160 32 , , , cord-349011-kxhpdvri 160 33 or or CC cord-349011-kxhpdvri 160 34 interferon interferon NN cord-349011-kxhpdvri 160 35 - - HYPH cord-349011-kxhpdvri 160 36 induced induce VBN cord-349011-kxhpdvri 160 37 protein protein NN cord-349011-kxhpdvri 160 38 with with IN cord-349011-kxhpdvri 160 39 tetratricopeptide tetratricopeptide NNP cord-349011-kxhpdvri 160 40 repeats repeat VBZ cord-349011-kxhpdvri 160 41 ( ( -LRB- cord-349011-kxhpdvri 160 42 IFITs IFITs NNP cord-349011-kxhpdvri 160 43 ) ) -RRB- cord-349011-kxhpdvri 160 44 1 1 CD cord-349011-kxhpdvri 160 45 and and CC cord-349011-kxhpdvri 160 46 5 5 CD cord-349011-kxhpdvri 160 47 [ [ -LRB- cord-349011-kxhpdvri 160 48 44 44 CD cord-349011-kxhpdvri 160 49 ] ] -RRB- cord-349011-kxhpdvri 160 50 . . . cord-349011-kxhpdvri 161 1 5'-triphophate 5'-triphophate LS cord-349011-kxhpdvri 161 2 - - HYPH cord-349011-kxhpdvri 161 3 containing contain VBG cord-349011-kxhpdvri 161 4 RNAs rna NNS cord-349011-kxhpdvri 161 5 can can MD cord-349011-kxhpdvri 161 6 be be VB cord-349011-kxhpdvri 161 7 converted convert VBN cord-349011-kxhpdvri 161 8 to to IN cord-349011-kxhpdvri 161 9 5'-monophosphate 5'-monophosphate NNP cord-349011-kxhpdvri 161 10 RNA RNA NNP cord-349011-kxhpdvri 161 11 by by IN cord-349011-kxhpdvri 161 12 the the DT cord-349011-kxhpdvri 161 13 action action NN cord-349011-kxhpdvri 161 14 of of IN cord-349011-kxhpdvri 161 15 the the DT cord-349011-kxhpdvri 161 16 cytoplasmic cytoplasmic JJ cord-349011-kxhpdvri 161 17 pyrophosphatases pyrophosphatase NNS cord-349011-kxhpdvri 161 18 DOM3Z DOM3Z , cord-349011-kxhpdvri 161 19 and and CC cord-349011-kxhpdvri 161 20 DUSP11 dusp11 NN cord-349011-kxhpdvri 161 21 ; ; : cord-349011-kxhpdvri 161 22 they -PRON- PRP cord-349011-kxhpdvri 161 23 found find VBD cord-349011-kxhpdvri 161 24 that that IN cord-349011-kxhpdvri 161 25 RNA RNA NNP cord-349011-kxhpdvri 161 26 silencing silencing NN cord-349011-kxhpdvri 161 27 of of IN cord-349011-kxhpdvri 161 28 DOM3Z dom3z NN cord-349011-kxhpdvri 161 29 or or CC cord-349011-kxhpdvri 161 30 DUSP11 dusp11 NN cord-349011-kxhpdvri 162 1 rescued rescue VBN cord-349011-kxhpdvri 162 2 RNA RNA NNP cord-349011-kxhpdvri 162 3 accumulation accumulation NN cord-349011-kxhpdvri 162 4 of of IN cord-349011-kxhpdvri 162 5 HCV HCV NNP cord-349011-kxhpdvri 162 6 subgenomic subgenomic NNP cord-349011-kxhpdvri 162 7 replicons replicon NNS cord-349011-kxhpdvri 162 8 in in IN cord-349011-kxhpdvri 162 9 the the DT cord-349011-kxhpdvri 162 10 absence absence NN cord-349011-kxhpdvri 162 11 of of IN cord-349011-kxhpdvri 162 12 miR-122 miR-122 NNP cord-349011-kxhpdvri 162 13 , , , cord-349011-kxhpdvri 162 14 suggesting suggest VBG cord-349011-kxhpdvri 162 15 that that IN cord-349011-kxhpdvri 162 16 miR-122 miR-122 NNP cord-349011-kxhpdvri 162 17 normally normally RB cord-349011-kxhpdvri 162 18 protects protect VBZ cord-349011-kxhpdvri 162 19 the the DT cord-349011-kxhpdvri 162 20 5'-triphosphate 5'-triphosphate CD cord-349011-kxhpdvri 162 21 structure structure NN cord-349011-kxhpdvri 162 22 on on IN cord-349011-kxhpdvri 162 23 the the DT cord-349011-kxhpdvri 162 24 viral viral JJ cord-349011-kxhpdvri 162 25 RNA RNA NNP cord-349011-kxhpdvri 162 26 and and CC cord-349011-kxhpdvri 162 27 prevents prevent VBZ cord-349011-kxhpdvri 162 28 pyrophosphatase pyrophosphatase NN cord-349011-kxhpdvri 162 29 activity activity NN cord-349011-kxhpdvri 162 30 and and CC cord-349011-kxhpdvri 162 31 subsequent subsequent JJ cord-349011-kxhpdvri 162 32 degradation degradation NN cord-349011-kxhpdvri 162 33 by by IN cord-349011-kxhpdvri 162 34 Xrn1/2 Xrn1/2 NNP cord-349011-kxhpdvri 162 35 . . . cord-349011-kxhpdvri 163 1 Using use VBG cord-349011-kxhpdvri 163 2 Selective selective JJ cord-349011-kxhpdvri 163 3 2 2 CD cord-349011-kxhpdvri 163 4 ' ' '' cord-349011-kxhpdvri 163 5 Hydroxyl Hydroxyl NNP cord-349011-kxhpdvri 163 6 Acylation Acylation NNP cord-349011-kxhpdvri 163 7 analyzed analyze VBN cord-349011-kxhpdvri 163 8 by by IN cord-349011-kxhpdvri 163 9 Primer Primer NNP cord-349011-kxhpdvri 163 10 Extension Extension NNP cord-349011-kxhpdvri 163 11 ( ( -LRB- cord-349011-kxhpdvri 163 12 SHAPE shape NN cord-349011-kxhpdvri 163 13 ) ) -RRB- cord-349011-kxhpdvri 163 14 , , , cord-349011-kxhpdvri 163 15 the the DT cord-349011-kxhpdvri 163 16 Sagan Sagan NNP cord-349011-kxhpdvri 163 17 lab lab NN cord-349011-kxhpdvri 163 18 is be VBZ cord-349011-kxhpdvri 163 19 exploring explore VBG cord-349011-kxhpdvri 163 20 how how WRB cord-349011-kxhpdvri 163 21 mutations mutation NNS cord-349011-kxhpdvri 163 22 in in IN cord-349011-kxhpdvri 163 23 the the DT cord-349011-kxhpdvri 163 24 5 5 CD cord-349011-kxhpdvri 163 25 ' ' `` cord-349011-kxhpdvri 163 26 non non JJ cord-349011-kxhpdvri 163 27 - - JJ cord-349011-kxhpdvri 163 28 coding coding JJ cord-349011-kxhpdvri 163 29 region region NN cord-349011-kxhpdvri 163 30 of of IN cord-349011-kxhpdvri 163 31 HCV HCV NNP cord-349011-kxhpdvri 163 32 genomes genome NNS cord-349011-kxhpdvri 163 33 from from IN cord-349011-kxhpdvri 163 34 patient patient JJ cord-349011-kxhpdvri 163 35 isolates isolate NNS cord-349011-kxhpdvri 163 36 may may MD cord-349011-kxhpdvri 163 37 help help VB cord-349011-kxhpdvri 163 38 to to TO cord-349011-kxhpdvri 163 39 promote promote VB cord-349011-kxhpdvri 163 40 genome genome NN cord-349011-kxhpdvri 163 41 stability stability NN cord-349011-kxhpdvri 163 42 and and CC cord-349011-kxhpdvri 163 43 relieve relieve VB cord-349011-kxhpdvri 163 44 HCV HCV NNP cord-349011-kxhpdvri 163 45 's 's POS cord-349011-kxhpdvri 163 46 dependence dependence NN cord-349011-kxhpdvri 163 47 on on IN cord-349011-kxhpdvri 163 48 miR-122 miR-122 NNP cord-349011-kxhpdvri 163 49 . . . cord-349011-kxhpdvri 164 1 However however RB cord-349011-kxhpdvri 164 2 , , , cord-349011-kxhpdvri 164 3 there there EX cord-349011-kxhpdvri 164 4 is be VBZ cord-349011-kxhpdvri 164 5 evidence evidence NN cord-349011-kxhpdvri 164 6 to to TO cord-349011-kxhpdvri 164 7 support support VB cord-349011-kxhpdvri 164 8 an an DT cord-349011-kxhpdvri 164 9 additional additional JJ cord-349011-kxhpdvri 164 10 role role NN cord-349011-kxhpdvri 164 11 for for IN cord-349011-kxhpdvri 164 12 miR-122 miR-122 NNP cord-349011-kxhpdvri 164 13 in in IN cord-349011-kxhpdvri 164 14 the the DT cord-349011-kxhpdvri 164 15 HCV HCV NNP cord-349011-kxhpdvri 164 16 replication replication NN cord-349011-kxhpdvri 164 17 cycle cycle NN cord-349011-kxhpdvri 164 18 beyond beyond IN cord-349011-kxhpdvri 164 19 genome genome NN cord-349011-kxhpdvri 164 20 stabilization stabilization NN cord-349011-kxhpdvri 164 21 . . . cord-349011-kxhpdvri 165 1 Influenza Influenza NNP cord-349011-kxhpdvri 165 2 A a DT cord-349011-kxhpdvri 165 3 virus virus NN cord-349011-kxhpdvri 165 4 infection infection NN cord-349011-kxhpdvri 165 5 delivers deliver VBZ cord-349011-kxhpdvri 165 6 eight eight CD cord-349011-kxhpdvri 165 7 ( ( -LRB- cord-349011-kxhpdvri 165 8 −)-sense −)-sense `` cord-349011-kxhpdvri 165 9 single single JJ cord-349011-kxhpdvri 165 10 - - HYPH cord-349011-kxhpdvri 165 11 stranded strand VBN cord-349011-kxhpdvri 165 12 viral viral JJ cord-349011-kxhpdvri 165 13 RNA RNA NNP cord-349011-kxhpdvri 165 14 ( ( -LRB- cord-349011-kxhpdvri 165 15 vRNA vrna JJ cord-349011-kxhpdvri 165 16 ) ) -RRB- cord-349011-kxhpdvri 165 17 genome genome NN cord-349011-kxhpdvri 165 18 segments segment NNS cord-349011-kxhpdvri 165 19 to to IN cord-349011-kxhpdvri 165 20 the the DT cord-349011-kxhpdvri 165 21 cell cell NN cord-349011-kxhpdvri 165 22 nucleus nucleus NN cord-349011-kxhpdvri 165 23 , , , cord-349011-kxhpdvri 165 24 each each DT cord-349011-kxhpdvri 165 25 bound bind VBN cord-349011-kxhpdvri 165 26 to to IN cord-349011-kxhpdvri 165 27 the the DT cord-349011-kxhpdvri 165 28 tripartite tripartite JJ cord-349011-kxhpdvri 165 29 viral viral JJ cord-349011-kxhpdvri 165 30 RNA RNA NNP cord-349011-kxhpdvri 165 31 - - HYPH cord-349011-kxhpdvri 165 32 dependent dependent JJ cord-349011-kxhpdvri 165 33 RNA RNA NNP cord-349011-kxhpdvri 165 34 polymerase polymerase NN cord-349011-kxhpdvri 165 35 ( ( -LRB- cord-349011-kxhpdvri 165 36 RdRp RdRp NNP cord-349011-kxhpdvri 165 37 ) ) -RRB- cord-349011-kxhpdvri 165 38 complex complex NN cord-349011-kxhpdvri 165 39 . . . cord-349011-kxhpdvri 166 1 To to TO cord-349011-kxhpdvri 166 2 initiate initiate VB cord-349011-kxhpdvri 166 3 transcription transcription NN cord-349011-kxhpdvri 166 4 , , , cord-349011-kxhpdvri 166 5 the the DT cord-349011-kxhpdvri 166 6 RdRp RdRp NNP cord-349011-kxhpdvri 166 7 complex complex NN cord-349011-kxhpdvri 166 8 simultaneously simultaneously RB cord-349011-kxhpdvri 166 9 binds bind VBZ cord-349011-kxhpdvri 166 10 to to TO cord-349011-kxhpdvri 166 11 host host VB cord-349011-kxhpdvri 166 12 RNA RNA NNP cord-349011-kxhpdvri 166 13 polymerase polymerase NN cord-349011-kxhpdvri 166 14 II II NNP cord-349011-kxhpdvri 166 15 ( ( -LRB- cord-349011-kxhpdvri 166 16 Pol Pol NNP cord-349011-kxhpdvri 166 17 II II NNP cord-349011-kxhpdvri 166 18 ) ) -RRB- cord-349011-kxhpdvri 166 19 and and CC cord-349011-kxhpdvri 166 20 5'-cap 5'-cap CD cord-349011-kxhpdvri 166 21 structures structure NNS cord-349011-kxhpdvri 166 22 on on IN cord-349011-kxhpdvri 167 1 nascent nascent JJ cord-349011-kxhpdvri 167 2 host host NN cord-349011-kxhpdvri 167 3 pre pre VB cord-349011-kxhpdvri 167 4 - - NNS cord-349011-kxhpdvri 167 5 mRNAs mrnas CD cord-349011-kxhpdvri 167 6 . . . cord-349011-kxhpdvri 168 1 Once once RB cord-349011-kxhpdvri 168 2 in in IN cord-349011-kxhpdvri 168 3 position position NN cord-349011-kxhpdvri 168 4 , , , cord-349011-kxhpdvri 168 5 the the DT cord-349011-kxhpdvri 168 6 polymerase polymerase NN cord-349011-kxhpdvri 168 7 acidic acidic JJ cord-349011-kxhpdvri 168 8 ( ( -LRB- cord-349011-kxhpdvri 168 9 PA PA NNP cord-349011-kxhpdvri 168 10 ) ) -RRB- cord-349011-kxhpdvri 168 11 subunit subunit NN cord-349011-kxhpdvri 168 12 of of IN cord-349011-kxhpdvri 168 13 the the DT cord-349011-kxhpdvri 168 14 RdRp RdRp NNP cord-349011-kxhpdvri 168 15 complex complex NN cord-349011-kxhpdvri 168 16 catalyzes catalyze VBZ cord-349011-kxhpdvri 168 17 endoribonucleolytic endoribonucleolytic JJ cord-349011-kxhpdvri 168 18 cleavage cleavage NN cord-349011-kxhpdvri 168 19 of of IN cord-349011-kxhpdvri 168 20 host host NN cord-349011-kxhpdvri 168 21 pre pre NNS cord-349011-kxhpdvri 168 22 - - NNS cord-349011-kxhpdvri 168 23 mRNAs mrna NNS cord-349011-kxhpdvri 168 24 at at IN cord-349011-kxhpdvri 168 25 a a DT cord-349011-kxhpdvri 168 26 position position NN cord-349011-kxhpdvri 168 27 10 10 CD cord-349011-kxhpdvri 168 28 - - SYM cord-349011-kxhpdvri 168 29 15 15 CD cord-349011-kxhpdvri 168 30 nucleotides nucleotide NNS cord-349011-kxhpdvri 168 31 downstream downstream RB cord-349011-kxhpdvri 168 32 of of IN cord-349011-kxhpdvri 168 33 the the DT cord-349011-kxhpdvri 168 34 5'-cap 5'-cap CD cord-349011-kxhpdvri 168 35 structure structure NN cord-349011-kxhpdvri 168 36 . . . cord-349011-kxhpdvri 169 1 This this DT cord-349011-kxhpdvri 169 2 process process NN cord-349011-kxhpdvri 169 3 , , , cord-349011-kxhpdvri 169 4 known know VBN cord-349011-kxhpdvri 169 5 as as IN cord-349011-kxhpdvri 169 6 " " `` cord-349011-kxhpdvri 169 7 cap cap NN cord-349011-kxhpdvri 169 8 - - HYPH cord-349011-kxhpdvri 169 9 snatching snatching NN cord-349011-kxhpdvri 169 10 " " '' cord-349011-kxhpdvri 169 11 , , , cord-349011-kxhpdvri 169 12 enables enable VBZ cord-349011-kxhpdvri 169 13 priming priming NN cord-349011-kxhpdvri 169 14 of of IN cord-349011-kxhpdvri 169 15 viral viral JJ cord-349011-kxhpdvri 169 16 mRNA mRNA NNP cord-349011-kxhpdvri 169 17 synthesis synthesis NN cord-349011-kxhpdvri 169 18 . . . cord-349011-kxhpdvri 170 1 It -PRON- PRP cord-349011-kxhpdvri 170 2 remains remain VBZ cord-349011-kxhpdvri 170 3 unclear unclear JJ cord-349011-kxhpdvri 170 4 whether whether IN cord-349011-kxhpdvri 170 5 there there EX cord-349011-kxhpdvri 170 6 is be VBZ cord-349011-kxhpdvri 170 7 some some DT cord-349011-kxhpdvri 170 8 selectivity selectivity NN cord-349011-kxhpdvri 170 9 in in IN cord-349011-kxhpdvri 170 10 this this DT cord-349011-kxhpdvri 170 11 process process NN cord-349011-kxhpdvri 170 12 , , , cord-349011-kxhpdvri 170 13 or or CC cord-349011-kxhpdvri 170 14 the the DT cord-349011-kxhpdvri 170 15 RdRp RdRp NNP cord-349011-kxhpdvri 170 16 simply simply RB cord-349011-kxhpdvri 170 17 " " `` cord-349011-kxhpdvri 170 18 snatches snatch VBZ cord-349011-kxhpdvri 170 19 " " '' cord-349011-kxhpdvri 170 20 these these DT cord-349011-kxhpdvri 170 21 primers primer NNS cord-349011-kxhpdvri 170 22 from from IN cord-349011-kxhpdvri 170 23 the the DT cord-349011-kxhpdvri 170 24 most most RBS cord-349011-kxhpdvri 170 25 abundant abundant JJ cord-349011-kxhpdvri 170 26 nearby nearby JJ cord-349011-kxhpdvri 170 27 host host NN cord-349011-kxhpdvri 171 1 pre pre VB cord-349011-kxhpdvri 171 2 - - NNS cord-349011-kxhpdvri 171 3 mRNAs mrnas CD cord-349011-kxhpdvri 171 4 . . . cord-349011-kxhpdvri 172 1 Dr. Dr. NNP cord-349011-kxhpdvri 172 2 Martin Martin NNP cord-349011-kxhpdvri 172 3 Pelchat Pelchat NNP cord-349011-kxhpdvri 172 4 ( ( -LRB- cord-349011-kxhpdvri 172 5 University University NNP cord-349011-kxhpdvri 172 6 of of IN cord-349011-kxhpdvri 172 7 Ottawa Ottawa NNP cord-349011-kxhpdvri 172 8 ) ) -RRB- cord-349011-kxhpdvri 172 9 described describe VBD cord-349011-kxhpdvri 172 10 deep deep JJ cord-349011-kxhpdvri 172 11 sequencing sequencing NN cord-349011-kxhpdvri 172 12 studies study NNS cord-349011-kxhpdvri 172 13 that that WDT cord-349011-kxhpdvri 172 14 support support VBP cord-349011-kxhpdvri 172 15 a a DT cord-349011-kxhpdvri 172 16 more more RBR cord-349011-kxhpdvri 172 17 nuanced nuanced JJ cord-349011-kxhpdvri 172 18 model model NN cord-349011-kxhpdvri 172 19 of of IN cord-349011-kxhpdvri 172 20 cap cap NN cord-349011-kxhpdvri 172 21 - - HYPH cord-349011-kxhpdvri 172 22 snatching snatching NN cord-349011-kxhpdvri 172 23 that that WDT cord-349011-kxhpdvri 172 24 integrates integrate VBZ cord-349011-kxhpdvri 172 25 host host NN cord-349011-kxhpdvri 172 26 pre pre JJ cord-349011-kxhpdvri 172 27 - - JJ cord-349011-kxhpdvri 172 28 mRNA mrna JJ cord-349011-kxhpdvri 172 29 abundance abundance NN cord-349011-kxhpdvri 172 30 with with IN cord-349011-kxhpdvri 172 31 selectivity selectivity NN cord-349011-kxhpdvri 172 32 , , , cord-349011-kxhpdvri 172 33 whereby whereby WRB cord-349011-kxhpdvri 172 34 each each DT cord-349011-kxhpdvri 172 35 of of IN cord-349011-kxhpdvri 172 36 the the DT cord-349011-kxhpdvri 172 37 eight eight CD cord-349011-kxhpdvri 172 38 RdRp RdRp NNP cord-349011-kxhpdvri 172 39 : : : cord-349011-kxhpdvri 172 40 vRNA vrna JJ cord-349011-kxhpdvri 172 41 complexes complex NNS cord-349011-kxhpdvri 172 42 acquire acquire VBP cord-349011-kxhpdvri 172 43 distinct distinct JJ cord-349011-kxhpdvri 172 44 subsets subset NNS cord-349011-kxhpdvri 172 45 of of IN cord-349011-kxhpdvri 172 46 host host NN cord-349011-kxhpdvri 172 47 RNAs rna NNS cord-349011-kxhpdvri 172 48 due due JJ cord-349011-kxhpdvri 172 49 to to IN cord-349011-kxhpdvri 172 50 differences difference NNS cord-349011-kxhpdvri 172 51 in in IN cord-349011-kxhpdvri 172 52 vRNA vrna JJ cord-349011-kxhpdvri 172 53 untranslated untranslated JJ cord-349011-kxhpdvri 172 54 region region NN cord-349011-kxhpdvri 172 55 ( ( -LRB- cord-349011-kxhpdvri 172 56 UTR UTR NNP cord-349011-kxhpdvri 172 57 ) ) -RRB- cord-349011-kxhpdvri 172 58 sequence sequence NN cord-349011-kxhpdvri 172 59 [ [ -LRB- cord-349011-kxhpdvri 172 60 45 45 CD cord-349011-kxhpdvri 172 61 , , , cord-349011-kxhpdvri 172 62 46 46 CD cord-349011-kxhpdvri 172 63 ] ] -RRB- cord-349011-kxhpdvri 172 64 . . . cord-349011-kxhpdvri 173 1 Importantly importantly RB cord-349011-kxhpdvri 173 2 , , , cord-349011-kxhpdvri 173 3 he -PRON- PRP cord-349011-kxhpdvri 173 4 reported report VBD cord-349011-kxhpdvri 173 5 that that IN cord-349011-kxhpdvri 173 6 host host NN cord-349011-kxhpdvri 173 7 mRNAs mrnas CD cord-349011-kxhpdvri 173 8 associated associate VBN cord-349011-kxhpdvri 173 9 with with IN cord-349011-kxhpdvri 173 10 antiviral antiviral JJ cord-349011-kxhpdvri 173 11 responses response NNS cord-349011-kxhpdvri 173 12 are be VBP cord-349011-kxhpdvri 173 13 over over RB cord-349011-kxhpdvri 173 14 - - HYPH cord-349011-kxhpdvri 173 15 represented represent VBN cord-349011-kxhpdvri 173 16 in in IN cord-349011-kxhpdvri 173 17 the the DT cord-349011-kxhpdvri 173 18 cap cap NN cord-349011-kxhpdvri 173 19 - - HYPH cord-349011-kxhpdvri 173 20 snatched snatch VBN cord-349011-kxhpdvri 173 21 population population NN cord-349011-kxhpdvri 173 22 . . . cord-349011-kxhpdvri 174 1 This this DT cord-349011-kxhpdvri 174 2 suggests suggest VBZ cord-349011-kxhpdvri 174 3 that that IN cord-349011-kxhpdvri 174 4 cap cap NN cord-349011-kxhpdvri 174 5 - - HYPH cord-349011-kxhpdvri 174 6 snatching snatching NN cord-349011-kxhpdvri 174 7 may may MD cord-349011-kxhpdvri 174 8 indeed indeed RB cord-349011-kxhpdvri 174 9 play play VB cord-349011-kxhpdvri 174 10 an an DT cord-349011-kxhpdvri 174 11 important important JJ cord-349011-kxhpdvri 174 12 role role NN cord-349011-kxhpdvri 174 13 in in IN cord-349011-kxhpdvri 174 14 influenza influenza NN cord-349011-kxhpdvri 174 15 A a DT cord-349011-kxhpdvri 174 16 virus virus NN cord-349011-kxhpdvri 174 17 - - HYPH cord-349011-kxhpdvri 174 18 host host NN cord-349011-kxhpdvri 174 19 shutoff shutoff NN cord-349011-kxhpdvri 174 20 . . . cord-349011-kxhpdvri 175 1 The the DT cord-349011-kxhpdvri 175 2 " " `` cord-349011-kxhpdvri 175 3 RNA RNA NNP cord-349011-kxhpdvri 175 4 in in IN cord-349011-kxhpdvri 175 5 Virus Virus NNP cord-349011-kxhpdvri 175 6 Infection infection NN cord-349011-kxhpdvri 175 7 " " '' cord-349011-kxhpdvri 175 8 session session NN cord-349011-kxhpdvri 175 9 also also RB cord-349011-kxhpdvri 175 10 included include VBD cord-349011-kxhpdvri 175 11 presentations presentation NNS cord-349011-kxhpdvri 175 12 from from IN cord-349011-kxhpdvri 175 13 the the DT cord-349011-kxhpdvri 175 14 following follow VBG cord-349011-kxhpdvri 175 15 trainees trainee NNS cord-349011-kxhpdvri 175 16 : : : cord-349011-kxhpdvri 175 17 Carolyn Carolyn NNP cord-349011-kxhpdvri 175 18 Robinson Robinson NNP cord-349011-kxhpdvri 175 19 ( ( -LRB- cord-349011-kxhpdvri 175 20 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 175 21 University University NNP cord-349011-kxhpdvri 175 22 ) ) -RRB- cord-349011-kxhpdvri 175 23 who who WP cord-349011-kxhpdvri 175 24 discussed discuss VBD cord-349011-kxhpdvri 175 25 Kaposi Kaposi NNP cord-349011-kxhpdvri 175 26 's 's POS cord-349011-kxhpdvri 175 27 sarcoma sarcoma NN cord-349011-kxhpdvri 175 28 - - HYPH cord-349011-kxhpdvri 175 29 associated associate VBN cord-349011-kxhpdvri 175 30 herpesvirus herpesvirus NN cord-349011-kxhpdvri 175 31 ( ( -LRB- cord-349011-kxhpdvri 175 32 KSHV KSHV NNP cord-349011-kxhpdvri 175 33 ) ) -RRB- cord-349011-kxhpdvri 175 34 modulation modulation NN cord-349011-kxhpdvri 175 35 of of IN cord-349011-kxhpdvri 175 36 RNA RNA NNP cord-349011-kxhpdvri 175 37 granules granule NNS cord-349011-kxhpdvri 175 38 , , , cord-349011-kxhpdvri 175 39 Eric Eric NNP cord-349011-kxhpdvri 175 40 Pringle Pringle NNP cord-349011-kxhpdvri 175 41 ( ( -LRB- cord-349011-kxhpdvri 175 42 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 175 43 University University NNP cord-349011-kxhpdvri 175 44 ) ) -RRB- cord-349011-kxhpdvri 175 45 who who WP cord-349011-kxhpdvri 175 46 discussed discuss VBD cord-349011-kxhpdvri 175 47 how how WRB cord-349011-kxhpdvri 175 48 KSHV KSHV NNP cord-349011-kxhpdvri 175 49 mRNAs mRNAs NNPS cord-349011-kxhpdvri 175 50 are be VBP cord-349011-kxhpdvri 175 51 translated translate VBN cord-349011-kxhpdvri 175 52 [ [ -LRB- cord-349011-kxhpdvri 175 53 47 47 CD cord-349011-kxhpdvri 175 54 ] ] -RRB- cord-349011-kxhpdvri 175 55 , , , cord-349011-kxhpdvri 175 56 and and CC cord-349011-kxhpdvri 175 57 Tyler Tyler NNP cord-349011-kxhpdvri 175 58 Mrozowich Mrozowich NNP cord-349011-kxhpdvri 175 59 ( ( -LRB- cord-349011-kxhpdvri 175 60 University University NNP cord-349011-kxhpdvri 175 61 of of IN cord-349011-kxhpdvri 175 62 Lethbridge Lethbridge NNP cord-349011-kxhpdvri 175 63 ) ) -RRB- cord-349011-kxhpdvri 175 64 who who WP cord-349011-kxhpdvri 175 65 presented present VBD cord-349011-kxhpdvri 175 66 structural structural JJ cord-349011-kxhpdvri 175 67 analysis analysis NN cord-349011-kxhpdvri 175 68 of of IN cord-349011-kxhpdvri 175 69 the the DT cord-349011-kxhpdvri 175 70 Japanese japanese JJ cord-349011-kxhpdvri 175 71 encephalitis encephalitis NNP cord-349011-kxhpdvri 175 72 virus virus NN cord-349011-kxhpdvri 175 73 RNA RNA NNP cord-349011-kxhpdvri 175 74 genome genome NN cord-349011-kxhpdvri 175 75 . . . cord-349011-kxhpdvri 176 1 The the DT cord-349011-kxhpdvri 176 2 " " `` cord-349011-kxhpdvri 176 3 This This NNP cord-349011-kxhpdvri 176 4 Week Week NNP cord-349011-kxhpdvri 176 5 in in IN cord-349011-kxhpdvri 176 6 Virology Virology NNP cord-349011-kxhpdvri 176 7 " " '' cord-349011-kxhpdvri 176 8 or or CC cord-349011-kxhpdvri 176 9 " " `` cord-349011-kxhpdvri 176 10 TWiV twiv JJ cord-349011-kxhpdvri 176 11 " " '' cord-349011-kxhpdvri 176 12 podcast podcast NN cord-349011-kxhpdvri 176 13 was be VBD cord-349011-kxhpdvri 176 14 created create VBN cord-349011-kxhpdvri 176 15 in in IN cord-349011-kxhpdvri 176 16 September September NNP cord-349011-kxhpdvri 176 17 2008 2008 CD cord-349011-kxhpdvri 176 18 by by IN cord-349011-kxhpdvri 176 19 Columbia Columbia NNP cord-349011-kxhpdvri 176 20 University University NNP cord-349011-kxhpdvri 176 21 Professors Professors NNPS cord-349011-kxhpdvri 176 22 Vincent Vincent NNP cord-349011-kxhpdvri 176 23 Racaniello Racaniello NNP cord-349011-kxhpdvri 176 24 and and CC cord-349011-kxhpdvri 176 25 Dickson Dickson NNP cord-349011-kxhpdvri 176 26 Despommier Despommier NNP cord-349011-kxhpdvri 176 27 to to TO cord-349011-kxhpdvri 176 28 discuss discuss VB cord-349011-kxhpdvri 176 29 science science NN cord-349011-kxhpdvri 176 30 in in IN cord-349011-kxhpdvri 176 31 an an DT cord-349011-kxhpdvri 176 32 informal informal JJ cord-349011-kxhpdvri 176 33 and and CC cord-349011-kxhpdvri 176 34 informative informative JJ cord-349011-kxhpdvri 176 35 manner manner NN cord-349011-kxhpdvri 176 36 . . . cord-349011-kxhpdvri 177 1 Ten ten CD cord-349011-kxhpdvri 177 2 years year NNS cord-349011-kxhpdvri 177 3 later later RB cord-349011-kxhpdvri 177 4 , , , cord-349011-kxhpdvri 177 5 Dr. Dr. NNP cord-349011-kxhpdvri 177 6 Racaniello Racaniello NNP cord-349011-kxhpdvri 177 7 and and CC cord-349011-kxhpdvri 177 8 TWIV TWIV NNP cord-349011-kxhpdvri 177 9 co co VBD cord-349011-kxhpdvri 177 10 - - NN cord-349011-kxhpdvri 177 11 host host NN cord-349011-kxhpdvri 177 12 Dr. Dr. NNP cord-349011-kxhpdvri 177 13 Alan Alan NNP cord-349011-kxhpdvri 177 14 Dove Dove NNP cord-349011-kxhpdvri 177 15 accepted accept VBD cord-349011-kxhpdvri 177 16 our -PRON- PRP$ cord-349011-kxhpdvri 177 17 invitation invitation NN cord-349011-kxhpdvri 177 18 to to TO cord-349011-kxhpdvri 177 19 record record VB cord-349011-kxhpdvri 177 20 their -PRON- PRP$ cord-349011-kxhpdvri 177 21 499th 499th JJ cord-349011-kxhpdvri 177 22 podcast podcast NN cord-349011-kxhpdvri 177 23 at at IN cord-349011-kxhpdvri 177 24 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 177 25 . . . cord-349011-kxhpdvri 178 1 After after IN cord-349011-kxhpdvri 178 2 discussing discuss VBG cord-349011-kxhpdvri 178 3 the the DT cord-349011-kxhpdvri 178 4 weather weather NN cord-349011-kxhpdvri 178 5 ( ( -LRB- cord-349011-kxhpdvri 178 6 as as IN cord-349011-kxhpdvri 178 7 is be VBZ cord-349011-kxhpdvri 178 8 their -PRON- PRP$ cord-349011-kxhpdvri 178 9 custom custom NN cord-349011-kxhpdvri 178 10 ) ) -RRB- cord-349011-kxhpdvri 178 11 , , , cord-349011-kxhpdvri 178 12 the the DT cord-349011-kxhpdvri 178 13 TWiV twiv JJ cord-349011-kxhpdvri 178 14 hosts host NNS cord-349011-kxhpdvri 178 15 got get VBD cord-349011-kxhpdvri 178 16 down down RP cord-349011-kxhpdvri 178 17 to to IN cord-349011-kxhpdvri 178 18 business business NN cord-349011-kxhpdvri 178 19 with with IN cord-349011-kxhpdvri 178 20 an an DT cord-349011-kxhpdvri 178 21 interview interview NN cord-349011-kxhpdvri 178 22 of of IN cord-349011-kxhpdvri 178 23 Drs Drs NNP cord-349011-kxhpdvri 178 24 . . . cord-349011-kxhpdvri 179 1 Grandvaux Grandvaux NNP cord-349011-kxhpdvri 179 2 and and CC cord-349011-kxhpdvri 179 3 McCormick McCormick NNP cord-349011-kxhpdvri 179 4 , , , cord-349011-kxhpdvri 179 5 who who WP cord-349011-kxhpdvri 179 6 discussed discuss VBD cord-349011-kxhpdvri 179 7 their -PRON- PRP$ cord-349011-kxhpdvri 179 8 motivation motivation NN cord-349011-kxhpdvri 179 9 in in IN cord-349011-kxhpdvri 179 10 founding found VBG cord-349011-kxhpdvri 179 11 the the DT cord-349011-kxhpdvri 179 12 CSV csv NN cord-349011-kxhpdvri 179 13 , , , cord-349011-kxhpdvri 179 14 the the DT cord-349011-kxhpdvri 179 15 current current JJ cord-349011-kxhpdvri 179 16 research research NN cord-349011-kxhpdvri 179 17 funding funding NN cord-349011-kxhpdvri 179 18 climate climate NN cord-349011-kxhpdvri 179 19 in in IN cord-349011-kxhpdvri 179 20 Canada Canada NNP cord-349011-kxhpdvri 179 21 , , , cord-349011-kxhpdvri 179 22 and and CC cord-349011-kxhpdvri 179 23 plans plan NNS cord-349011-kxhpdvri 179 24 for for IN cord-349011-kxhpdvri 179 25 the the DT cord-349011-kxhpdvri 179 26 new new JJ cord-349011-kxhpdvri 179 27 society society NN cord-349011-kxhpdvri 179 28 ( ( -LRB- cord-349011-kxhpdvri 179 29 Figure figure NN cord-349011-kxhpdvri 179 30 3 3 CD cord-349011-kxhpdvri 179 31 ) ) -RRB- cord-349011-kxhpdvri 179 32 . . . cord-349011-kxhpdvri 180 1 They -PRON- PRP cord-349011-kxhpdvri 180 2 also also RB cord-349011-kxhpdvri 180 3 interviewed interview VBD cord-349011-kxhpdvri 180 4 Dr. Dr. NNP cord-349011-kxhpdvri 180 5 Ryan Ryan NNP cord-349011-kxhpdvri 180 6 Noyce Noyce NNP cord-349011-kxhpdvri 180 7 from from IN cord-349011-kxhpdvri 180 8 the the DT cord-349011-kxhpdvri 180 9 University University NNP cord-349011-kxhpdvri 180 10 of of IN cord-349011-kxhpdvri 180 11 Alberta Alberta NNP cord-349011-kxhpdvri 180 12 , , , cord-349011-kxhpdvri 180 13 who who WP cord-349011-kxhpdvri 180 14 discussed discuss VBD cord-349011-kxhpdvri 180 15 his -PRON- PRP$ cord-349011-kxhpdvri 180 16 high high JJ cord-349011-kxhpdvri 180 17 - - HYPH cord-349011-kxhpdvri 180 18 profile profile NN cord-349011-kxhpdvri 180 19 synthetic synthetic JJ cord-349011-kxhpdvri 180 20 virology virology NN cord-349011-kxhpdvri 180 21 ( ( -LRB- cord-349011-kxhpdvri 180 22 or or CC cord-349011-kxhpdvri 180 23 " " `` cord-349011-kxhpdvri 180 24 SynViro SynViro NNP cord-349011-kxhpdvri 180 25 " " '' cord-349011-kxhpdvri 180 26 ) ) -RRB- cord-349011-kxhpdvri 180 27 research research NN cord-349011-kxhpdvri 180 28 project project NN cord-349011-kxhpdvri 180 29 , , , cord-349011-kxhpdvri 180 30 in in IN cord-349011-kxhpdvri 180 31 which which WDT cord-349011-kxhpdvri 180 32 he -PRON- PRP cord-349011-kxhpdvri 180 33 used use VBD cord-349011-kxhpdvri 180 34 principles principle NNS cord-349011-kxhpdvri 180 35 of of IN cord-349011-kxhpdvri 180 36 synthetic synthetic JJ cord-349011-kxhpdvri 180 37 biology biology NN cord-349011-kxhpdvri 180 38 to to TO cord-349011-kxhpdvri 180 39 create create VB cord-349011-kxhpdvri 180 40 a a DT cord-349011-kxhpdvri 180 41 horsepox horsepox NNP cord-349011-kxhpdvri 180 42 virus virus NN cord-349011-kxhpdvri 180 43 vector vector NN cord-349011-kxhpdvri 180 44 that that WDT cord-349011-kxhpdvri 180 45 could could MD cord-349011-kxhpdvri 180 46 be be VB cord-349011-kxhpdvri 180 47 used use VBN cord-349011-kxhpdvri 180 48 as as IN cord-349011-kxhpdvri 180 49 the the DT cord-349011-kxhpdvri 180 50 basis basis NN cord-349011-kxhpdvri 180 51 for for IN cord-349011-kxhpdvri 180 52 new new JJ cord-349011-kxhpdvri 180 53 poxvirus poxvirus NNP cord-349011-kxhpdvri 180 54 vaccines vaccine NNS cord-349011-kxhpdvri 180 55 and and CC cord-349011-kxhpdvri 180 56 oncolytic oncolytic JJ cord-349011-kxhpdvri 180 57 viruses virus NNS cord-349011-kxhpdvri 180 58 [ [ -LRB- cord-349011-kxhpdvri 180 59 41 41 CD cord-349011-kxhpdvri 180 60 , , , cord-349011-kxhpdvri 180 61 48 48 CD cord-349011-kxhpdvri 180 62 ] ] -RRB- cord-349011-kxhpdvri 180 63 . . . cord-349011-kxhpdvri 181 1 This this DT cord-349011-kxhpdvri 181 2 project project NN cord-349011-kxhpdvri 181 3 had have VBD cord-349011-kxhpdvri 181 4 been be VBN cord-349011-kxhpdvri 181 5 previously previously RB cord-349011-kxhpdvri 181 6 discussed discuss VBN cord-349011-kxhpdvri 181 7 on on IN cord-349011-kxhpdvri 181 8 TWiV TWiV NNP cord-349011-kxhpdvri 181 9 478 478 CD cord-349011-kxhpdvri 181 10 , , , cord-349011-kxhpdvri 181 11 entitled entitle VBN cord-349011-kxhpdvri 181 12 " " `` cord-349011-kxhpdvri 181 13 A a DT cord-349011-kxhpdvri 181 14 pox pox NN cord-349011-kxhpdvri 181 15 on on IN cord-349011-kxhpdvri 181 16 your -PRON- PRP$ cord-349011-kxhpdvri 181 17 horse horse NN cord-349011-kxhpdvri 181 18 " " '' cord-349011-kxhpdvri 181 19 [ [ -LRB- cord-349011-kxhpdvri 181 20 49 49 CD cord-349011-kxhpdvri 181 21 ] ] -RRB- cord-349011-kxhpdvri 181 22 , , , cord-349011-kxhpdvri 181 23 and and CC cord-349011-kxhpdvri 181 24 received receive VBD cord-349011-kxhpdvri 181 25 scrutiny scrutiny NN cord-349011-kxhpdvri 181 26 in in IN cord-349011-kxhpdvri 181 27 the the DT cord-349011-kxhpdvri 181 28 scientific scientific JJ cord-349011-kxhpdvri 181 29 and and CC cord-349011-kxhpdvri 181 30 mainstream mainstream JJ cord-349011-kxhpdvri 181 31 media medium NNS cord-349011-kxhpdvri 181 32 due due JJ cord-349011-kxhpdvri 181 33 to to IN cord-349011-kxhpdvri 181 34 concerns concern NNS cord-349011-kxhpdvri 181 35 about about IN cord-349011-kxhpdvri 181 36 ethics ethic NNS cord-349011-kxhpdvri 181 37 and and CC cord-349011-kxhpdvri 181 38 potential potential JJ cord-349011-kxhpdvri 181 39 " " `` cord-349011-kxhpdvri 181 40 dual dual JJ cord-349011-kxhpdvri 181 41 - - HYPH cord-349011-kxhpdvri 181 42 use use NN cord-349011-kxhpdvri 181 43 " " '' cord-349011-kxhpdvri 181 44 of of IN cord-349011-kxhpdvri 181 45 these these DT cord-349011-kxhpdvri 181 46 new new JJ cord-349011-kxhpdvri 181 47 poxviruses poxvirus NNS cord-349011-kxhpdvri 181 48 . . . cord-349011-kxhpdvri 182 1 Finally finally RB cord-349011-kxhpdvri 182 2 , , , cord-349011-kxhpdvri 182 3 the the DT cord-349011-kxhpdvri 182 4 TWiV twiv JJ cord-349011-kxhpdvri 182 5 team team NN cord-349011-kxhpdvri 182 6 interviewed interview VBD cord-349011-kxhpdvri 182 7 Dr. Dr. NNP cord-349011-kxhpdvri 182 8 Kate Kate NNP cord-349011-kxhpdvri 182 9 O'Brien O'Brien NNP cord-349011-kxhpdvri 182 10 from from IN cord-349011-kxhpdvri 182 11 Johns Johns NNP cord-349011-kxhpdvri 182 12 Hopkins Hopkins NNP cord-349011-kxhpdvri 182 13 University University NNP cord-349011-kxhpdvri 182 14 , , , cord-349011-kxhpdvri 182 15 who who WP cord-349011-kxhpdvri 182 16 discussed discuss VBD cord-349011-kxhpdvri 182 17 her -PRON- PRP$ cord-349011-kxhpdvri 182 18 global global JJ cord-349011-kxhpdvri 182 19 health health NN cord-349011-kxhpdvri 182 20 research research NN cord-349011-kxhpdvri 182 21 in in IN cord-349011-kxhpdvri 182 22 vaccines vaccine NNS cord-349011-kxhpdvri 182 23 , , , cord-349011-kxhpdvri 182 24 and and CC cord-349011-kxhpdvri 182 25 in in IN cord-349011-kxhpdvri 182 26 particular particular JJ cord-349011-kxhpdvri 182 27 how how WRB cord-349011-kxhpdvri 182 28 certain certain JJ cord-349011-kxhpdvri 182 29 viruses virus NNS cord-349011-kxhpdvri 182 30 are be VBP cord-349011-kxhpdvri 182 31 etiologically etiologically RB cord-349011-kxhpdvri 182 32 linked link VBN cord-349011-kxhpdvri 182 33 to to IN cord-349011-kxhpdvri 182 34 severe severe JJ cord-349011-kxhpdvri 182 35 pneumonia pneumonia NN cord-349011-kxhpdvri 182 36 in in IN cord-349011-kxhpdvri 182 37 the the DT cord-349011-kxhpdvri 182 38 developing develop VBG cord-349011-kxhpdvri 182 39 world world NN cord-349011-kxhpdvri 182 40 . . . cord-349011-kxhpdvri 183 1 The the DT cord-349011-kxhpdvri 183 2 podcast podcast NN cord-349011-kxhpdvri 183 3 was be VBD cord-349011-kxhpdvri 183 4 entitled entitle VBN cord-349011-kxhpdvri 183 5 " " `` cord-349011-kxhpdvri 183 6 Good good JJ cord-349011-kxhpdvri 183 7 virologists virologist NNS cord-349011-kxhpdvri 183 8 go go VBP cord-349011-kxhpdvri 183 9 to to IN cord-349011-kxhpdvri 183 10 Halifax Halifax NNP cord-349011-kxhpdvri 183 11 " " '' cord-349011-kxhpdvri 183 12 [ [ -LRB- cord-349011-kxhpdvri 183 13 50 50 CD cord-349011-kxhpdvri 183 14 ] ] -RRB- cord-349011-kxhpdvri 183 15 . . . cord-349011-kxhpdvri 184 1 Viruses virus NNS cord-349011-kxhpdvri 184 2 2019 2019 CD cord-349011-kxhpdvri 184 3 , , , cord-349011-kxhpdvri 184 4 11 11 CD cord-349011-kxhpdvri 184 5 , , , cord-349011-kxhpdvri 184 6 x x NN cord-349011-kxhpdvri 184 7 FOR for IN cord-349011-kxhpdvri 184 8 PEER PEER NNP cord-349011-kxhpdvri 184 9 REVIEW REVIEW NNP cord-349011-kxhpdvri 184 10 10 10 CD cord-349011-kxhpdvri 184 11 of of IN cord-349011-kxhpdvri 184 12 17 17 CD cord-349011-kxhpdvri 184 13 which which WDT cord-349011-kxhpdvri 184 14 he -PRON- PRP cord-349011-kxhpdvri 184 15 used use VBD cord-349011-kxhpdvri 184 16 principles principle NNS cord-349011-kxhpdvri 184 17 of of IN cord-349011-kxhpdvri 184 18 synthetic synthetic JJ cord-349011-kxhpdvri 184 19 biology biology NN cord-349011-kxhpdvri 184 20 to to TO cord-349011-kxhpdvri 184 21 create create VB cord-349011-kxhpdvri 184 22 a a DT cord-349011-kxhpdvri 184 23 horsepox horsepox NNP cord-349011-kxhpdvri 184 24 virus virus NN cord-349011-kxhpdvri 184 25 vector vector NN cord-349011-kxhpdvri 184 26 that that WDT cord-349011-kxhpdvri 184 27 could could MD cord-349011-kxhpdvri 184 28 be be VB cord-349011-kxhpdvri 184 29 used use VBN cord-349011-kxhpdvri 184 30 as as IN cord-349011-kxhpdvri 184 31 the the DT cord-349011-kxhpdvri 184 32 basis basis NN cord-349011-kxhpdvri 184 33 for for IN cord-349011-kxhpdvri 184 34 new new JJ cord-349011-kxhpdvri 184 35 poxvirus poxvirus NNP cord-349011-kxhpdvri 184 36 vaccines vaccine NNS cord-349011-kxhpdvri 184 37 and and CC cord-349011-kxhpdvri 184 38 oncolytic oncolytic JJ cord-349011-kxhpdvri 184 39 viruses virus NNS cord-349011-kxhpdvri 184 40 [ [ -LRB- cord-349011-kxhpdvri 184 41 41 41 CD cord-349011-kxhpdvri 184 42 , , , cord-349011-kxhpdvri 184 43 48 48 CD cord-349011-kxhpdvri 184 44 ] ] -RRB- cord-349011-kxhpdvri 184 45 . . . cord-349011-kxhpdvri 185 1 This this DT cord-349011-kxhpdvri 185 2 project project NN cord-349011-kxhpdvri 185 3 had have VBD cord-349011-kxhpdvri 185 4 been be VBN cord-349011-kxhpdvri 185 5 previously previously RB cord-349011-kxhpdvri 185 6 discussed discuss VBN cord-349011-kxhpdvri 185 7 on on IN cord-349011-kxhpdvri 185 8 TWiV TWiV NNP cord-349011-kxhpdvri 185 9 478 478 CD cord-349011-kxhpdvri 185 10 , , , cord-349011-kxhpdvri 185 11 entitled entitle VBN cord-349011-kxhpdvri 185 12 " " `` cord-349011-kxhpdvri 185 13 A a DT cord-349011-kxhpdvri 185 14 pox pox NN cord-349011-kxhpdvri 185 15 on on IN cord-349011-kxhpdvri 185 16 your -PRON- PRP$ cord-349011-kxhpdvri 185 17 horse horse NN cord-349011-kxhpdvri 185 18 " " '' cord-349011-kxhpdvri 185 19 [ [ -LRB- cord-349011-kxhpdvri 185 20 49 49 CD cord-349011-kxhpdvri 185 21 ] ] -RRB- cord-349011-kxhpdvri 185 22 , , , cord-349011-kxhpdvri 185 23 and and CC cord-349011-kxhpdvri 185 24 received receive VBD cord-349011-kxhpdvri 185 25 scrutiny scrutiny NN cord-349011-kxhpdvri 185 26 in in IN cord-349011-kxhpdvri 185 27 the the DT cord-349011-kxhpdvri 185 28 scientific scientific JJ cord-349011-kxhpdvri 185 29 and and CC cord-349011-kxhpdvri 185 30 mainstream mainstream JJ cord-349011-kxhpdvri 185 31 media medium NNS cord-349011-kxhpdvri 185 32 due due JJ cord-349011-kxhpdvri 185 33 to to IN cord-349011-kxhpdvri 185 34 concerns concern NNS cord-349011-kxhpdvri 185 35 about about IN cord-349011-kxhpdvri 185 36 ethics ethic NNS cord-349011-kxhpdvri 185 37 and and CC cord-349011-kxhpdvri 185 38 potential potential JJ cord-349011-kxhpdvri 185 39 " " `` cord-349011-kxhpdvri 185 40 dual dual JJ cord-349011-kxhpdvri 185 41 - - HYPH cord-349011-kxhpdvri 185 42 use use NN cord-349011-kxhpdvri 185 43 " " '' cord-349011-kxhpdvri 185 44 of of IN cord-349011-kxhpdvri 185 45 these these DT cord-349011-kxhpdvri 185 46 new new JJ cord-349011-kxhpdvri 185 47 poxviruses poxvirus NNS cord-349011-kxhpdvri 185 48 . . . cord-349011-kxhpdvri 186 1 Finally finally RB cord-349011-kxhpdvri 186 2 , , , cord-349011-kxhpdvri 186 3 the the DT cord-349011-kxhpdvri 186 4 TWiV twiv JJ cord-349011-kxhpdvri 186 5 team team NN cord-349011-kxhpdvri 186 6 interviewed interview VBD cord-349011-kxhpdvri 186 7 Dr. Dr. NNP cord-349011-kxhpdvri 186 8 Kate Kate NNP cord-349011-kxhpdvri 186 9 O'Brien O'Brien NNP cord-349011-kxhpdvri 186 10 from from IN cord-349011-kxhpdvri 186 11 Johns Johns NNP cord-349011-kxhpdvri 186 12 Hopkins Hopkins NNP cord-349011-kxhpdvri 186 13 University University NNP cord-349011-kxhpdvri 186 14 , , , cord-349011-kxhpdvri 186 15 who who WP cord-349011-kxhpdvri 186 16 discussed discuss VBD cord-349011-kxhpdvri 186 17 her -PRON- PRP$ cord-349011-kxhpdvri 186 18 global global JJ cord-349011-kxhpdvri 186 19 health health NN cord-349011-kxhpdvri 186 20 research research NN cord-349011-kxhpdvri 186 21 in in IN cord-349011-kxhpdvri 186 22 vaccines vaccine NNS cord-349011-kxhpdvri 186 23 , , , cord-349011-kxhpdvri 186 24 and and CC cord-349011-kxhpdvri 186 25 in in IN cord-349011-kxhpdvri 186 26 particular particular JJ cord-349011-kxhpdvri 186 27 how how WRB cord-349011-kxhpdvri 186 28 certain certain JJ cord-349011-kxhpdvri 186 29 viruses virus NNS cord-349011-kxhpdvri 186 30 are be VBP cord-349011-kxhpdvri 186 31 etiologically etiologically RB cord-349011-kxhpdvri 186 32 linked link VBN cord-349011-kxhpdvri 186 33 to to IN cord-349011-kxhpdvri 186 34 severe severe JJ cord-349011-kxhpdvri 186 35 pneumonia pneumonia NN cord-349011-kxhpdvri 186 36 in in IN cord-349011-kxhpdvri 186 37 the the DT cord-349011-kxhpdvri 186 38 developing develop VBG cord-349011-kxhpdvri 186 39 world world NN cord-349011-kxhpdvri 186 40 . . . cord-349011-kxhpdvri 187 1 The the DT cord-349011-kxhpdvri 187 2 podcast podcast NN cord-349011-kxhpdvri 187 3 was be VBD cord-349011-kxhpdvri 187 4 entitled entitle VBN cord-349011-kxhpdvri 187 5 " " `` cord-349011-kxhpdvri 187 6 Good good JJ cord-349011-kxhpdvri 187 7 virologists virologist NNS cord-349011-kxhpdvri 187 8 go go VBP cord-349011-kxhpdvri 187 9 to to IN cord-349011-kxhpdvri 187 10 Halifax Halifax NNP cord-349011-kxhpdvri 187 11 " " '' cord-349011-kxhpdvri 187 12 [ [ -LRB- cord-349011-kxhpdvri 187 13 50 50 CD cord-349011-kxhpdvri 187 14 ] ] -RRB- cord-349011-kxhpdvri 187 15 . . . cord-349011-kxhpdvri 187 16 _SP cord-349011-kxhpdvri 188 1 After after IN cord-349011-kxhpdvri 188 2 the the DT cord-349011-kxhpdvri 188 3 TWiV twiv JJ cord-349011-kxhpdvri 188 4 live live NN cord-349011-kxhpdvri 188 5 - - HYPH cord-349011-kxhpdvri 188 6 taping taping NN cord-349011-kxhpdvri 188 7 , , , cord-349011-kxhpdvri 188 8 our -PRON- PRP$ cord-349011-kxhpdvri 188 9 program program NN cord-349011-kxhpdvri 188 10 resumed resume VBD cord-349011-kxhpdvri 188 11 on on IN cord-349011-kxhpdvri 188 12 the the DT cord-349011-kxhpdvri 188 13 topic topic NN cord-349011-kxhpdvri 188 14 of of IN cord-349011-kxhpdvri 188 15 " " `` cord-349011-kxhpdvri 188 16 Viruses Viruses NNPS cord-349011-kxhpdvri 188 17 of of IN cord-349011-kxhpdvri 188 18 Flora Flora NNP cord-349011-kxhpdvri 188 19 and and CC cord-349011-kxhpdvri 188 20 Fauna Fauna NNP cord-349011-kxhpdvri 188 21 " " '' cord-349011-kxhpdvri 188 22 , , , cord-349011-kxhpdvri 188 23 with with IN cord-349011-kxhpdvri 188 24 Dr. Dr. NNP cord-349011-kxhpdvri 188 25 Eric Eric NNP cord-349011-kxhpdvri 188 26 Jan Jan NNP cord-349011-kxhpdvri 188 27 ( ( -LRB- cord-349011-kxhpdvri 188 28 University University NNP cord-349011-kxhpdvri 188 29 of of IN cord-349011-kxhpdvri 188 30 British British NNP cord-349011-kxhpdvri 188 31 Columbia Columbia NNP cord-349011-kxhpdvri 188 32 ) ) -RRB- cord-349011-kxhpdvri 188 33 chairing chair VBG cord-349011-kxhpdvri 188 34 and and CC cord-349011-kxhpdvri 188 35 giving give VBG cord-349011-kxhpdvri 188 36 the the DT cord-349011-kxhpdvri 188 37 first first JJ cord-349011-kxhpdvri 188 38 talk talk NN cord-349011-kxhpdvri 188 39 . . . cord-349011-kxhpdvri 189 1 Internal internal JJ cord-349011-kxhpdvri 189 2 ribosome ribosome NN cord-349011-kxhpdvri 189 3 entry entry NN cord-349011-kxhpdvri 189 4 sites site NNS cord-349011-kxhpdvri 189 5 ( ( -LRB- cord-349011-kxhpdvri 189 6 IRES IRES NNP cord-349011-kxhpdvri 189 7 ) ) -RRB- cord-349011-kxhpdvri 189 8 can can MD cord-349011-kxhpdvri 189 9 start start VB cord-349011-kxhpdvri 189 10 translation translation NN cord-349011-kxhpdvri 189 11 in in IN cord-349011-kxhpdvri 189 12 alternative alternative JJ cord-349011-kxhpdvri 189 13 reading reading NN cord-349011-kxhpdvri 189 14 frames frame NNS cord-349011-kxhpdvri 189 15 . . . cord-349011-kxhpdvri 190 1 For for IN cord-349011-kxhpdvri 190 2 example example NN cord-349011-kxhpdvri 190 3 , , , cord-349011-kxhpdvri 190 4 Dr. Dr. NNP cord-349011-kxhpdvri 190 5 Jan Jan NNP cord-349011-kxhpdvri 190 6 's 's POS cord-349011-kxhpdvri 190 7 lab lab NN cord-349011-kxhpdvri 190 8 previously previously RB cord-349011-kxhpdvri 190 9 showed show VBD cord-349011-kxhpdvri 190 10 that that IN cord-349011-kxhpdvri 190 11 the the DT cord-349011-kxhpdvri 190 12 IRES IRES NNP cord-349011-kxhpdvri 190 13 of of IN cord-349011-kxhpdvri 190 14 the the DT cord-349011-kxhpdvri 190 15 honey honey NN cord-349011-kxhpdvri 190 16 bee bee NN cord-349011-kxhpdvri 190 17 dicistrovirus dicistrovirus NNP cord-349011-kxhpdvri 190 18 not not RB cord-349011-kxhpdvri 190 19 only only RB cord-349011-kxhpdvri 190 20 directs direct VBZ cord-349011-kxhpdvri 190 21 translation translation NN cord-349011-kxhpdvri 190 22 in in IN cord-349011-kxhpdvri 190 23 the the DT cord-349011-kxhpdvri 190 24 0 0 CD cord-349011-kxhpdvri 190 25 reading reading NN cord-349011-kxhpdvri 190 26 frame frame NN cord-349011-kxhpdvri 190 27 yielding yield VBG cord-349011-kxhpdvri 190 28 a a DT cord-349011-kxhpdvri 190 29 polyprotein polyprotein NN cord-349011-kxhpdvri 190 30 , , , cord-349011-kxhpdvri 190 31 but but CC cord-349011-kxhpdvri 190 32 also also RB cord-349011-kxhpdvri 190 33 in in IN cord-349011-kxhpdvri 190 34 the the DT cord-349011-kxhpdvri 190 35 +1 +1 HYPH cord-349011-kxhpdvri 190 36 reading reading NN cord-349011-kxhpdvri 190 37 frame frame NN cord-349011-kxhpdvri 190 38 [ [ -LRB- cord-349011-kxhpdvri 190 39 51 51 CD cord-349011-kxhpdvri 190 40 , , , cord-349011-kxhpdvri 190 41 52 52 CD cord-349011-kxhpdvri 190 42 ] ] -RRB- cord-349011-kxhpdvri 190 43 . . . cord-349011-kxhpdvri 191 1 Dr. Dr. NNP cord-349011-kxhpdvri 191 2 Jan Jan NNP cord-349011-kxhpdvri 191 3 reported report VBD cord-349011-kxhpdvri 191 4 that that IN cord-349011-kxhpdvri 191 5 the the DT cord-349011-kxhpdvri 191 6 IRES IRES NNP cord-349011-kxhpdvri 191 7 of of IN cord-349011-kxhpdvri 191 8 the the DT cord-349011-kxhpdvri 191 9 related relate VBN cord-349011-kxhpdvri 191 10 dicistrovirus dicistrovirus NNP cord-349011-kxhpdvri 191 11 Cricket Cricket NNP cord-349011-kxhpdvri 191 12 paralysis paralysis NN cord-349011-kxhpdvri 191 13 virus virus NN cord-349011-kxhpdvri 191 14 ( ( -LRB- cord-349011-kxhpdvri 191 15 CrPV CrPV NNP cord-349011-kxhpdvri 191 16 ) ) -RRB- cord-349011-kxhpdvri 191 17 also also RB cord-349011-kxhpdvri 191 18 promotes promote VBZ cord-349011-kxhpdvri 191 19 translation translation NN cord-349011-kxhpdvri 191 20 in in IN cord-349011-kxhpdvri 191 21 the the DT cord-349011-kxhpdvri 191 22 +1 +1 HYPH cord-349011-kxhpdvri 191 23 reading reading NN cord-349011-kxhpdvri 191 24 frame frame NN cord-349011-kxhpdvri 191 25 , , , cord-349011-kxhpdvri 191 26 resulting result VBG cord-349011-kxhpdvri 191 27 in in IN cord-349011-kxhpdvri 191 28 the the DT cord-349011-kxhpdvri 191 29 translation translation NN cord-349011-kxhpdvri 191 30 of of IN cord-349011-kxhpdvri 191 31 a a DT cord-349011-kxhpdvri 191 32 new new JJ cord-349011-kxhpdvri 191 33 protein protein NN cord-349011-kxhpdvri 191 34 called call VBN cord-349011-kxhpdvri 191 35 ORFx ORFx NNP cord-349011-kxhpdvri 191 36 [ [ -LRB- cord-349011-kxhpdvri 191 37 53 53 CD cord-349011-kxhpdvri 191 38 ] ] -RRB- cord-349011-kxhpdvri 191 39 . . . cord-349011-kxhpdvri 192 1 However however RB cord-349011-kxhpdvri 192 2 , , , cord-349011-kxhpdvri 192 3 unlike unlike IN cord-349011-kxhpdvri 192 4 the the DT cord-349011-kxhpdvri 192 5 honey honey NN cord-349011-kxhpdvri 192 6 bee bee NN cord-349011-kxhpdvri 192 7 IRES IRES NNP cord-349011-kxhpdvri 192 8 , , , cord-349011-kxhpdvri 192 9 a a DT cord-349011-kxhpdvri 192 10 subset subset NN cord-349011-kxhpdvri 192 11 of of IN cord-349011-kxhpdvri 192 12 ribosomes ribosome NNS cord-349011-kxhpdvri 192 13 recruited recruit VBN cord-349011-kxhpdvri 192 14 to to IN cord-349011-kxhpdvri 192 15 the the DT cord-349011-kxhpdvri 192 16 CrPV CrPV NNP cord-349011-kxhpdvri 192 17 IRES IRES NNP cord-349011-kxhpdvri 192 18 can can MD cord-349011-kxhpdvri 192 19 undergo undergo VB cord-349011-kxhpdvri 192 20 a a DT cord-349011-kxhpdvri 192 21 bypass bypass NN cord-349011-kxhpdvri 192 22 mechanism mechanism NN cord-349011-kxhpdvri 192 23 to to TO cord-349011-kxhpdvri 192 24 initiate initiate VB cord-349011-kxhpdvri 192 25 translation translation NN cord-349011-kxhpdvri 192 26 downstream downstream RB cord-349011-kxhpdvri 192 27 at at IN cord-349011-kxhpdvri 192 28 the the DT cord-349011-kxhpdvri 192 29 +1 +1 HYPH cord-349011-kxhpdvri 192 30 frame frame NN cord-349011-kxhpdvri 192 31 13th 13th JJ cord-349011-kxhpdvri 192 32 non non NNP cord-349011-kxhpdvri 192 33 - - JJ cord-349011-kxhpdvri 192 34 AUG AUG NNP cord-349011-kxhpdvri 192 35 codon codon NN cord-349011-kxhpdvri 192 36 . . . cord-349011-kxhpdvri 193 1 Dr. Dr. NNP cord-349011-kxhpdvri 193 2 Jan Jan NNP cord-349011-kxhpdvri 193 3 showed show VBD cord-349011-kxhpdvri 193 4 that that IN cord-349011-kxhpdvri 193 5 mutagenesis mutagenesis NN cord-349011-kxhpdvri 193 6 of of IN cord-349011-kxhpdvri 193 7 this this DT cord-349011-kxhpdvri 193 8 downstream downstream JJ cord-349011-kxhpdvri 193 9 +1 +1 HYPH cord-349011-kxhpdvri 193 10 frame frame NN cord-349011-kxhpdvri 193 11 ORFx ORFx NNPS cord-349011-kxhpdvri 193 12 attenuates attenuate VBZ cord-349011-kxhpdvri 193 13 the the DT cord-349011-kxhpdvri 193 14 virus virus NN cord-349011-kxhpdvri 193 15 in in IN cord-349011-kxhpdvri 193 16 a a DT cord-349011-kxhpdvri 193 17 Drosophila Drosophila NNP cord-349011-kxhpdvri 193 18 infection infection NN cord-349011-kxhpdvri 193 19 model model NN cord-349011-kxhpdvri 193 20 , , , cord-349011-kxhpdvri 193 21 suggesting suggest VBG cord-349011-kxhpdvri 193 22 that that IN cord-349011-kxhpdvri 193 23 ORFx ORFx NNP cord-349011-kxhpdvri 193 24 plays play VBZ cord-349011-kxhpdvri 193 25 a a DT cord-349011-kxhpdvri 193 26 role role NN cord-349011-kxhpdvri 193 27 in in IN cord-349011-kxhpdvri 193 28 viral viral JJ cord-349011-kxhpdvri 193 29 pathogenesis pathogenesis NN cord-349011-kxhpdvri 193 30 . . . cord-349011-kxhpdvri 194 1 These these DT cord-349011-kxhpdvri 194 2 studies study NNS cord-349011-kxhpdvri 194 3 highlight highlight VBP cord-349011-kxhpdvri 194 4 the the DT cord-349011-kxhpdvri 194 5 diversity diversity NN cord-349011-kxhpdvri 194 6 of of IN cord-349011-kxhpdvri 194 7 viral viral JJ cord-349011-kxhpdvri 194 8 translation translation NN cord-349011-kxhpdvri 194 9 recoding recode VBG cord-349011-kxhpdvri 194 10 mechanisms mechanism NNS cord-349011-kxhpdvri 194 11 to to TO cord-349011-kxhpdvri 194 12 increase increase VB cord-349011-kxhpdvri 194 13 coding code VBG cord-349011-kxhpdvri 194 14 capacity capacity NN cord-349011-kxhpdvri 194 15 . . . cord-349011-kxhpdvri 195 1 In in IN cord-349011-kxhpdvri 195 2 the the DT cord-349011-kxhpdvri 195 3 next next JJ cord-349011-kxhpdvri 195 4 talk talk NN cord-349011-kxhpdvri 195 5 , , , cord-349011-kxhpdvri 195 6 Hélène Hélène NNP cord-349011-kxhpdvri 195 7 Sanfaçon Sanfaçon NNP cord-349011-kxhpdvri 195 8 ( ( -LRB- cord-349011-kxhpdvri 195 9 Summerland Summerland NNP cord-349011-kxhpdvri 195 10 Research Research NNP cord-349011-kxhpdvri 195 11 and and CC cord-349011-kxhpdvri 195 12 Development Development NNP cord-349011-kxhpdvri 195 13 Centre Centre NNP cord-349011-kxhpdvri 195 14 , , , cord-349011-kxhpdvri 195 15 Agriculture Agriculture NNP cord-349011-kxhpdvri 195 16 and and CC cord-349011-kxhpdvri 195 17 Agri Agri NNP cord-349011-kxhpdvri 195 18 - - HYPH cord-349011-kxhpdvri 195 19 Food Food NNP cord-349011-kxhpdvri 195 20 Canada Canada NNP cord-349011-kxhpdvri 195 21 ) ) -RRB- cord-349011-kxhpdvri 195 22 presented present VBD cord-349011-kxhpdvri 195 23 evidence evidence NN cord-349011-kxhpdvri 195 24 for for IN cord-349011-kxhpdvri 195 25 non non JJ cord-349011-kxhpdvri 195 26 - - JJ cord-349011-kxhpdvri 195 27 canonical canonical JJ cord-349011-kxhpdvri 195 28 proteases protease NNS cord-349011-kxhpdvri 195 29 encoded encode VBN cord-349011-kxhpdvri 195 30 by by IN cord-349011-kxhpdvri 195 31 plant plant NN cord-349011-kxhpdvri 195 32 viruses virus NNS cord-349011-kxhpdvri 195 33 . . . cord-349011-kxhpdvri 196 1 Previously previously RB cord-349011-kxhpdvri 196 2 described describe VBN cord-349011-kxhpdvri 196 3 plant plant NN cord-349011-kxhpdvri 196 4 virus virus NN cord-349011-kxhpdvri 196 5 proteases protease NNS cord-349011-kxhpdvri 196 6 are be VBP cord-349011-kxhpdvri 196 7 grouped group VBN cord-349011-kxhpdvri 196 8 according accord VBG cord-349011-kxhpdvri 196 9 to to IN cord-349011-kxhpdvri 196 10 conserved conserved JJ cord-349011-kxhpdvri 196 11 catalytic catalytic JJ cord-349011-kxhpdvri 196 12 active active JJ cord-349011-kxhpdvri 196 13 site site NN cord-349011-kxhpdvri 196 14 residues residue NNS cord-349011-kxhpdvri 196 15 : : : cord-349011-kxhpdvri 196 16 cysteine cysteine NN cord-349011-kxhpdvri 196 17 , , , cord-349011-kxhpdvri 196 18 serine serine NN cord-349011-kxhpdvri 196 19 or or CC cord-349011-kxhpdvri 196 20 aspartic aspartic JJ cord-349011-kxhpdvri 196 21 acid acid NN cord-349011-kxhpdvri 196 22 [ [ -LRB- cord-349011-kxhpdvri 196 23 54 54 CD cord-349011-kxhpdvri 196 24 , , , cord-349011-kxhpdvri 196 25 55 55 CD cord-349011-kxhpdvri 196 26 ] ] -RRB- cord-349011-kxhpdvri 196 27 . . . cord-349011-kxhpdvri 197 1 Dr. Dr. NNP cord-349011-kxhpdvri 197 2 Sanfaçon Sanfaçon NNP cord-349011-kxhpdvri 197 3 described describe VBD cord-349011-kxhpdvri 197 4 investigations investigation NNS cord-349011-kxhpdvri 197 5 of of IN cord-349011-kxhpdvri 197 6 viruses virus NNS cord-349011-kxhpdvri 197 7 of of IN cord-349011-kxhpdvri 197 8 the the DT cord-349011-kxhpdvri 197 9 family family NN cord-349011-kxhpdvri 197 10 Secoviridae Secoviridae NNP cord-349011-kxhpdvri 197 11 that that WDT cord-349011-kxhpdvri 197 12 constitute constitute VBP cord-349011-kxhpdvri 197 13 a a DT cord-349011-kxhpdvri 197 14 large large JJ cord-349011-kxhpdvri 197 15 group group NN cord-349011-kxhpdvri 197 16 of of IN cord-349011-kxhpdvri 197 17 picorna picorna NNP cord-349011-kxhpdvri 197 18 - - HYPH cord-349011-kxhpdvri 197 19 like like JJ cord-349011-kxhpdvri 197 20 viruses virus NNS cord-349011-kxhpdvri 197 21 [ [ -LRB- cord-349011-kxhpdvri 197 22 56 56 CD cord-349011-kxhpdvri 197 23 ] ] -RRB- cord-349011-kxhpdvri 197 24 and and CC cord-349011-kxhpdvri 197 25 include include VBP cord-349011-kxhpdvri 197 26 strawberry strawberry NN cord-349011-kxhpdvri 197 27 mottle mottle NN cord-349011-kxhpdvri 197 28 virus virus NN cord-349011-kxhpdvri 197 29 ( ( -LRB- cord-349011-kxhpdvri 197 30 SMoV SMoV NNP cord-349011-kxhpdvri 197 31 ) ) -RRB- cord-349011-kxhpdvri 197 32 . . . cord-349011-kxhpdvri 198 1 SMoV SMoV NNP cord-349011-kxhpdvri 198 2 has have VBZ cord-349011-kxhpdvri 198 3 a a DT cord-349011-kxhpdvri 198 4 bipartite bipartite JJ cord-349011-kxhpdvri 198 5 genome genome NN cord-349011-kxhpdvri 198 6 , , , cord-349011-kxhpdvri 198 7 with with IN cord-349011-kxhpdvri 198 8 each each DT cord-349011-kxhpdvri 198 9 RNA RNA NNP cord-349011-kxhpdvri 198 10 encoding encode VBG cord-349011-kxhpdvri 198 11 a a DT cord-349011-kxhpdvri 198 12 large large JJ cord-349011-kxhpdvri 198 13 polyprotein polyprotein NN cord-349011-kxhpdvri 198 14 . . . cord-349011-kxhpdvri 199 1 RNA1 RNA1 NNP cord-349011-kxhpdvri 199 2 encodes encode VBZ cord-349011-kxhpdvri 199 3 a a DT cord-349011-kxhpdvri 199 4 cysteine cysteine NN cord-349011-kxhpdvri 199 5 protease protease NN cord-349011-kxhpdvri 199 6 that that WDT cord-349011-kxhpdvri 199 7 is be VBZ cord-349011-kxhpdvri 199 8 related relate VBN cord-349011-kxhpdvri 199 9 to to IN cord-349011-kxhpdvri 199 10 the the DT cord-349011-kxhpdvri 199 11 canonical canonical JJ cord-349011-kxhpdvri 199 12 3C 3C NNP cord-349011-kxhpdvri 199 13 protease protease NN cord-349011-kxhpdvri 199 14 of of IN cord-349011-kxhpdvri 199 15 picornaviruses picornavirus NNS cord-349011-kxhpdvri 199 16 and and CC cord-349011-kxhpdvri 199 17 cleaves cleave VBZ cord-349011-kxhpdvri 199 18 at at IN cord-349011-kxhpdvri 199 19 multiple multiple JJ cord-349011-kxhpdvri 199 20 locations location NNS cord-349011-kxhpdvri 199 21 on on IN cord-349011-kxhpdvri 199 22 polyproteins polyprotein NNS cord-349011-kxhpdvri 199 23 generated generate VBN cord-349011-kxhpdvri 199 24 from from IN cord-349011-kxhpdvri 199 25 RNA1 RNA1 NNP cord-349011-kxhpdvri 199 26 and and CC cord-349011-kxhpdvri 199 27 RNA2 RNA2 NNP cord-349011-kxhpdvri 199 28 [ [ -LRB- cord-349011-kxhpdvri 199 29 57 57 CD cord-349011-kxhpdvri 199 30 ] ] -RRB- cord-349011-kxhpdvri 199 31 . . . cord-349011-kxhpdvri 200 1 Dr. Dr. NNP cord-349011-kxhpdvri 200 2 Sanfaçon Sanfaçon NNP cord-349011-kxhpdvri 200 3 and and CC cord-349011-kxhpdvri 200 4 her -PRON- PRP$ cord-349011-kxhpdvri 200 5 team team NN cord-349011-kxhpdvri 200 6 detected detect VBD cord-349011-kxhpdvri 200 7 an an DT cord-349011-kxhpdvri 200 8 additional additional JJ cord-349011-kxhpdvri 200 9 proteolytic proteolytic JJ cord-349011-kxhpdvri 200 10 activity activity NN cord-349011-kxhpdvri 200 11 associated associate VBN cord-349011-kxhpdvri 200 12 with with IN cord-349011-kxhpdvri 200 13 the the DT cord-349011-kxhpdvri 200 14 carboxy carboxy JJ cord-349011-kxhpdvri 200 15 - - HYPH cord-349011-kxhpdvri 200 16 terminal terminal NN cord-349011-kxhpdvri 200 17 domain domain NN cord-349011-kxhpdvri 200 18 of of IN cord-349011-kxhpdvri 200 19 the the DT cord-349011-kxhpdvri 200 20 RNA2 RNA2 NNP cord-349011-kxhpdvri 200 21 polyprotein polyprotein NN cord-349011-kxhpdvri 200 22 [ [ -LRB- cord-349011-kxhpdvri 200 23 58 58 CD cord-349011-kxhpdvri 200 24 ] ] -RRB- cord-349011-kxhpdvri 200 25 . . . cord-349011-kxhpdvri 201 1 Surprisingly surprisingly RB cord-349011-kxhpdvri 201 2 , , , cord-349011-kxhpdvri 201 3 mutation mutation NN cord-349011-kxhpdvri 201 4 of of IN cord-349011-kxhpdvri 201 5 conserved conserved JJ cord-349011-kxhpdvri 201 6 serine serine NN cord-349011-kxhpdvri 201 7 , , , cord-349011-kxhpdvri 201 8 cysteine cysteine NN cord-349011-kxhpdvri 201 9 , , , cord-349011-kxhpdvri 201 10 histidine histidine NN cord-349011-kxhpdvri 201 11 or or CC cord-349011-kxhpdvri 201 12 aspartic aspartic JJ cord-349011-kxhpdvri 201 13 acid acid NN cord-349011-kxhpdvri 201 14 residues residue NNS cord-349011-kxhpdvri 201 15 did do VBD cord-349011-kxhpdvri 201 16 not not RB cord-349011-kxhpdvri 201 17 affect affect VB cord-349011-kxhpdvri 201 18 this this DT cord-349011-kxhpdvri 201 19 activity activity NN cord-349011-kxhpdvri 201 20 . . . cord-349011-kxhpdvri 202 1 Instead instead RB cord-349011-kxhpdvri 202 2 , , , cord-349011-kxhpdvri 202 3 two two CD cord-349011-kxhpdvri 202 4 glutamic glutamic NN cord-349011-kxhpdvri 202 5 acid acid NN cord-349011-kxhpdvri 202 6 residues residue NNS cord-349011-kxhpdvri 202 7 were be VBD cord-349011-kxhpdvri 202 8 shown show VBN cord-349011-kxhpdvri 202 9 to to TO cord-349011-kxhpdvri 202 10 be be VB cord-349011-kxhpdvri 202 11 _SP cord-349011-kxhpdvri 202 12 After after IN cord-349011-kxhpdvri 202 13 the the DT cord-349011-kxhpdvri 202 14 TWiV twiv JJ cord-349011-kxhpdvri 202 15 live live NN cord-349011-kxhpdvri 202 16 - - HYPH cord-349011-kxhpdvri 202 17 taping taping NN cord-349011-kxhpdvri 202 18 , , , cord-349011-kxhpdvri 202 19 our -PRON- PRP$ cord-349011-kxhpdvri 202 20 program program NN cord-349011-kxhpdvri 202 21 resumed resume VBD cord-349011-kxhpdvri 202 22 on on IN cord-349011-kxhpdvri 202 23 the the DT cord-349011-kxhpdvri 202 24 topic topic NN cord-349011-kxhpdvri 202 25 of of IN cord-349011-kxhpdvri 202 26 " " `` cord-349011-kxhpdvri 202 27 Viruses Viruses NNPS cord-349011-kxhpdvri 202 28 of of IN cord-349011-kxhpdvri 202 29 Flora Flora NNP cord-349011-kxhpdvri 202 30 and and CC cord-349011-kxhpdvri 202 31 Fauna Fauna NNP cord-349011-kxhpdvri 202 32 " " '' cord-349011-kxhpdvri 202 33 , , , cord-349011-kxhpdvri 202 34 with with IN cord-349011-kxhpdvri 202 35 Dr. Dr. NNP cord-349011-kxhpdvri 202 36 Eric Eric NNP cord-349011-kxhpdvri 202 37 Jan Jan NNP cord-349011-kxhpdvri 202 38 ( ( -LRB- cord-349011-kxhpdvri 202 39 University University NNP cord-349011-kxhpdvri 202 40 of of IN cord-349011-kxhpdvri 202 41 British British NNP cord-349011-kxhpdvri 202 42 Columbia Columbia NNP cord-349011-kxhpdvri 202 43 ) ) -RRB- cord-349011-kxhpdvri 202 44 chairing chair VBG cord-349011-kxhpdvri 202 45 and and CC cord-349011-kxhpdvri 202 46 giving give VBG cord-349011-kxhpdvri 202 47 the the DT cord-349011-kxhpdvri 202 48 first first JJ cord-349011-kxhpdvri 202 49 talk talk NN cord-349011-kxhpdvri 202 50 . . . cord-349011-kxhpdvri 203 1 Internal internal JJ cord-349011-kxhpdvri 203 2 ribosome ribosome NN cord-349011-kxhpdvri 203 3 entry entry NN cord-349011-kxhpdvri 203 4 sites site NNS cord-349011-kxhpdvri 203 5 ( ( -LRB- cord-349011-kxhpdvri 203 6 IRES IRES NNP cord-349011-kxhpdvri 203 7 ) ) -RRB- cord-349011-kxhpdvri 203 8 can can MD cord-349011-kxhpdvri 203 9 start start VB cord-349011-kxhpdvri 203 10 translation translation NN cord-349011-kxhpdvri 203 11 in in IN cord-349011-kxhpdvri 203 12 alternative alternative JJ cord-349011-kxhpdvri 203 13 reading reading NN cord-349011-kxhpdvri 203 14 frames frame NNS cord-349011-kxhpdvri 203 15 . . . cord-349011-kxhpdvri 204 1 For for IN cord-349011-kxhpdvri 204 2 example example NN cord-349011-kxhpdvri 204 3 , , , cord-349011-kxhpdvri 204 4 Dr. Dr. NNP cord-349011-kxhpdvri 204 5 Jan Jan NNP cord-349011-kxhpdvri 204 6 's 's POS cord-349011-kxhpdvri 204 7 lab lab NN cord-349011-kxhpdvri 204 8 previously previously RB cord-349011-kxhpdvri 204 9 showed show VBD cord-349011-kxhpdvri 204 10 that that IN cord-349011-kxhpdvri 204 11 the the DT cord-349011-kxhpdvri 204 12 IRES IRES NNP cord-349011-kxhpdvri 204 13 of of IN cord-349011-kxhpdvri 204 14 the the DT cord-349011-kxhpdvri 204 15 honey honey NN cord-349011-kxhpdvri 204 16 bee bee NN cord-349011-kxhpdvri 204 17 dicistrovirus dicistrovirus NNP cord-349011-kxhpdvri 204 18 not not RB cord-349011-kxhpdvri 204 19 only only RB cord-349011-kxhpdvri 204 20 directs direct VBZ cord-349011-kxhpdvri 204 21 translation translation NN cord-349011-kxhpdvri 204 22 in in IN cord-349011-kxhpdvri 204 23 the the DT cord-349011-kxhpdvri 204 24 0 0 CD cord-349011-kxhpdvri 204 25 reading reading NN cord-349011-kxhpdvri 204 26 frame frame NN cord-349011-kxhpdvri 204 27 yielding yield VBG cord-349011-kxhpdvri 204 28 a a DT cord-349011-kxhpdvri 204 29 polyprotein polyprotein NN cord-349011-kxhpdvri 204 30 , , , cord-349011-kxhpdvri 204 31 but but CC cord-349011-kxhpdvri 204 32 also also RB cord-349011-kxhpdvri 204 33 in in IN cord-349011-kxhpdvri 204 34 the the DT cord-349011-kxhpdvri 204 35 +1 +1 HYPH cord-349011-kxhpdvri 204 36 reading reading NN cord-349011-kxhpdvri 204 37 frame frame NN cord-349011-kxhpdvri 204 38 [ [ -LRB- cord-349011-kxhpdvri 204 39 51 51 CD cord-349011-kxhpdvri 204 40 , , , cord-349011-kxhpdvri 204 41 52 52 CD cord-349011-kxhpdvri 204 42 ] ] -RRB- cord-349011-kxhpdvri 204 43 . . . cord-349011-kxhpdvri 205 1 Dr. Dr. NNP cord-349011-kxhpdvri 205 2 Jan Jan NNP cord-349011-kxhpdvri 205 3 reported report VBD cord-349011-kxhpdvri 205 4 that that IN cord-349011-kxhpdvri 205 5 the the DT cord-349011-kxhpdvri 205 6 IRES IRES NNP cord-349011-kxhpdvri 205 7 of of IN cord-349011-kxhpdvri 205 8 the the DT cord-349011-kxhpdvri 205 9 related relate VBN cord-349011-kxhpdvri 205 10 dicistrovirus dicistrovirus NNP cord-349011-kxhpdvri 205 11 Cricket Cricket NNP cord-349011-kxhpdvri 205 12 paralysis paralysis NN cord-349011-kxhpdvri 205 13 virus virus NN cord-349011-kxhpdvri 205 14 ( ( -LRB- cord-349011-kxhpdvri 205 15 CrPV CrPV NNP cord-349011-kxhpdvri 205 16 ) ) -RRB- cord-349011-kxhpdvri 205 17 also also RB cord-349011-kxhpdvri 205 18 promotes promote VBZ cord-349011-kxhpdvri 205 19 translation translation NN cord-349011-kxhpdvri 205 20 in in IN cord-349011-kxhpdvri 205 21 the the DT cord-349011-kxhpdvri 205 22 +1 +1 HYPH cord-349011-kxhpdvri 205 23 reading reading NN cord-349011-kxhpdvri 205 24 frame frame NN cord-349011-kxhpdvri 205 25 , , , cord-349011-kxhpdvri 205 26 resulting result VBG cord-349011-kxhpdvri 205 27 in in IN cord-349011-kxhpdvri 205 28 the the DT cord-349011-kxhpdvri 205 29 translation translation NN cord-349011-kxhpdvri 205 30 of of IN cord-349011-kxhpdvri 205 31 a a DT cord-349011-kxhpdvri 205 32 new new JJ cord-349011-kxhpdvri 205 33 protein protein NN cord-349011-kxhpdvri 205 34 called call VBN cord-349011-kxhpdvri 205 35 ORFx ORFx NNP cord-349011-kxhpdvri 205 36 [ [ -LRB- cord-349011-kxhpdvri 205 37 53 53 CD cord-349011-kxhpdvri 205 38 ] ] -RRB- cord-349011-kxhpdvri 205 39 . . . cord-349011-kxhpdvri 206 1 However however RB cord-349011-kxhpdvri 206 2 , , , cord-349011-kxhpdvri 206 3 unlike unlike IN cord-349011-kxhpdvri 206 4 the the DT cord-349011-kxhpdvri 206 5 honey honey NN cord-349011-kxhpdvri 206 6 bee bee NN cord-349011-kxhpdvri 206 7 IRES IRES NNP cord-349011-kxhpdvri 206 8 , , , cord-349011-kxhpdvri 206 9 a a DT cord-349011-kxhpdvri 206 10 subset subset NN cord-349011-kxhpdvri 206 11 of of IN cord-349011-kxhpdvri 206 12 ribosomes ribosome NNS cord-349011-kxhpdvri 206 13 recruited recruit VBN cord-349011-kxhpdvri 206 14 to to IN cord-349011-kxhpdvri 206 15 the the DT cord-349011-kxhpdvri 206 16 CrPV CrPV NNP cord-349011-kxhpdvri 206 17 IRES IRES NNP cord-349011-kxhpdvri 206 18 can can MD cord-349011-kxhpdvri 206 19 undergo undergo VB cord-349011-kxhpdvri 206 20 a a DT cord-349011-kxhpdvri 206 21 bypass bypass NN cord-349011-kxhpdvri 206 22 mechanism mechanism NN cord-349011-kxhpdvri 206 23 to to TO cord-349011-kxhpdvri 206 24 initiate initiate VB cord-349011-kxhpdvri 206 25 translation translation NN cord-349011-kxhpdvri 206 26 downstream downstream RB cord-349011-kxhpdvri 206 27 at at IN cord-349011-kxhpdvri 206 28 the the DT cord-349011-kxhpdvri 206 29 +1 +1 HYPH cord-349011-kxhpdvri 206 30 frame frame NN cord-349011-kxhpdvri 206 31 13th 13th JJ cord-349011-kxhpdvri 206 32 non non NNP cord-349011-kxhpdvri 206 33 - - JJ cord-349011-kxhpdvri 206 34 AUG AUG NNP cord-349011-kxhpdvri 206 35 codon codon NN cord-349011-kxhpdvri 206 36 . . . cord-349011-kxhpdvri 207 1 Dr. Dr. NNP cord-349011-kxhpdvri 207 2 Jan Jan NNP cord-349011-kxhpdvri 207 3 showed show VBD cord-349011-kxhpdvri 207 4 that that IN cord-349011-kxhpdvri 207 5 mutagenesis mutagenesis NN cord-349011-kxhpdvri 207 6 of of IN cord-349011-kxhpdvri 207 7 this this DT cord-349011-kxhpdvri 207 8 downstream downstream JJ cord-349011-kxhpdvri 207 9 +1 +1 HYPH cord-349011-kxhpdvri 207 10 frame frame NN cord-349011-kxhpdvri 207 11 ORFx ORFx NNPS cord-349011-kxhpdvri 207 12 attenuates attenuate VBZ cord-349011-kxhpdvri 207 13 the the DT cord-349011-kxhpdvri 207 14 virus virus NN cord-349011-kxhpdvri 207 15 in in IN cord-349011-kxhpdvri 207 16 a a DT cord-349011-kxhpdvri 207 17 Drosophila Drosophila NNP cord-349011-kxhpdvri 207 18 infection infection NN cord-349011-kxhpdvri 207 19 model model NN cord-349011-kxhpdvri 207 20 , , , cord-349011-kxhpdvri 207 21 suggesting suggest VBG cord-349011-kxhpdvri 207 22 that that IN cord-349011-kxhpdvri 207 23 ORFx ORFx NNP cord-349011-kxhpdvri 207 24 plays play VBZ cord-349011-kxhpdvri 207 25 a a DT cord-349011-kxhpdvri 207 26 role role NN cord-349011-kxhpdvri 207 27 in in IN cord-349011-kxhpdvri 207 28 viral viral JJ cord-349011-kxhpdvri 207 29 pathogenesis pathogenesis NN cord-349011-kxhpdvri 207 30 . . . cord-349011-kxhpdvri 208 1 These these DT cord-349011-kxhpdvri 208 2 studies study NNS cord-349011-kxhpdvri 208 3 highlight highlight VBP cord-349011-kxhpdvri 208 4 the the DT cord-349011-kxhpdvri 208 5 diversity diversity NN cord-349011-kxhpdvri 208 6 of of IN cord-349011-kxhpdvri 208 7 viral viral JJ cord-349011-kxhpdvri 208 8 translation translation NN cord-349011-kxhpdvri 208 9 recoding recode VBG cord-349011-kxhpdvri 208 10 mechanisms mechanism NNS cord-349011-kxhpdvri 208 11 to to TO cord-349011-kxhpdvri 208 12 increase increase VB cord-349011-kxhpdvri 208 13 coding code VBG cord-349011-kxhpdvri 208 14 capacity capacity NN cord-349011-kxhpdvri 208 15 . . . cord-349011-kxhpdvri 209 1 In in IN cord-349011-kxhpdvri 209 2 the the DT cord-349011-kxhpdvri 209 3 next next JJ cord-349011-kxhpdvri 209 4 talk talk NN cord-349011-kxhpdvri 209 5 , , , cord-349011-kxhpdvri 209 6 Hélène Hélène NNP cord-349011-kxhpdvri 209 7 Sanfaçon Sanfaçon NNP cord-349011-kxhpdvri 209 8 ( ( -LRB- cord-349011-kxhpdvri 209 9 Summerland Summerland NNP cord-349011-kxhpdvri 209 10 Research Research NNP cord-349011-kxhpdvri 209 11 and and CC cord-349011-kxhpdvri 209 12 Development Development NNP cord-349011-kxhpdvri 209 13 Centre Centre NNP cord-349011-kxhpdvri 209 14 , , , cord-349011-kxhpdvri 209 15 Agriculture Agriculture NNP cord-349011-kxhpdvri 209 16 and and CC cord-349011-kxhpdvri 209 17 Agri Agri NNP cord-349011-kxhpdvri 209 18 - - HYPH cord-349011-kxhpdvri 209 19 Food Food NNP cord-349011-kxhpdvri 209 20 Canada Canada NNP cord-349011-kxhpdvri 209 21 ) ) -RRB- cord-349011-kxhpdvri 209 22 presented present VBD cord-349011-kxhpdvri 209 23 evidence evidence NN cord-349011-kxhpdvri 209 24 for for IN cord-349011-kxhpdvri 209 25 non non JJ cord-349011-kxhpdvri 209 26 - - JJ cord-349011-kxhpdvri 209 27 canonical canonical JJ cord-349011-kxhpdvri 209 28 proteases protease NNS cord-349011-kxhpdvri 209 29 encoded encode VBN cord-349011-kxhpdvri 209 30 by by IN cord-349011-kxhpdvri 209 31 plant plant NN cord-349011-kxhpdvri 209 32 viruses virus NNS cord-349011-kxhpdvri 209 33 . . . cord-349011-kxhpdvri 210 1 Previously previously RB cord-349011-kxhpdvri 210 2 described describe VBN cord-349011-kxhpdvri 210 3 plant plant NN cord-349011-kxhpdvri 210 4 virus virus NN cord-349011-kxhpdvri 210 5 proteases protease NNS cord-349011-kxhpdvri 210 6 are be VBP cord-349011-kxhpdvri 210 7 grouped group VBN cord-349011-kxhpdvri 210 8 according accord VBG cord-349011-kxhpdvri 210 9 to to IN cord-349011-kxhpdvri 210 10 conserved conserved JJ cord-349011-kxhpdvri 210 11 catalytic catalytic JJ cord-349011-kxhpdvri 210 12 active active JJ cord-349011-kxhpdvri 210 13 site site NN cord-349011-kxhpdvri 210 14 residues residue NNS cord-349011-kxhpdvri 210 15 : : : cord-349011-kxhpdvri 210 16 cysteine cysteine NN cord-349011-kxhpdvri 210 17 , , , cord-349011-kxhpdvri 210 18 serine serine NN cord-349011-kxhpdvri 210 19 or or CC cord-349011-kxhpdvri 210 20 aspartic aspartic JJ cord-349011-kxhpdvri 210 21 acid acid NN cord-349011-kxhpdvri 210 22 [ [ -LRB- cord-349011-kxhpdvri 210 23 54 54 CD cord-349011-kxhpdvri 210 24 , , , cord-349011-kxhpdvri 210 25 55 55 CD cord-349011-kxhpdvri 210 26 ] ] -RRB- cord-349011-kxhpdvri 210 27 . . . cord-349011-kxhpdvri 211 1 Dr. Dr. NNP cord-349011-kxhpdvri 211 2 Sanfaçon Sanfaçon NNP cord-349011-kxhpdvri 211 3 described describe VBD cord-349011-kxhpdvri 211 4 investigations investigation NNS cord-349011-kxhpdvri 211 5 of of IN cord-349011-kxhpdvri 211 6 viruses virus NNS cord-349011-kxhpdvri 211 7 of of IN cord-349011-kxhpdvri 211 8 the the DT cord-349011-kxhpdvri 211 9 family family NN cord-349011-kxhpdvri 211 10 Secoviridae Secoviridae NNP cord-349011-kxhpdvri 211 11 that that WDT cord-349011-kxhpdvri 211 12 constitute constitute VBP cord-349011-kxhpdvri 211 13 a a DT cord-349011-kxhpdvri 211 14 large large JJ cord-349011-kxhpdvri 211 15 group group NN cord-349011-kxhpdvri 211 16 of of IN cord-349011-kxhpdvri 211 17 picorna picorna NNP cord-349011-kxhpdvri 211 18 - - HYPH cord-349011-kxhpdvri 211 19 like like JJ cord-349011-kxhpdvri 211 20 viruses virus NNS cord-349011-kxhpdvri 211 21 [ [ -LRB- cord-349011-kxhpdvri 211 22 56 56 CD cord-349011-kxhpdvri 211 23 ] ] -RRB- cord-349011-kxhpdvri 211 24 and and CC cord-349011-kxhpdvri 211 25 include include VBP cord-349011-kxhpdvri 211 26 strawberry strawberry NN cord-349011-kxhpdvri 211 27 mottle mottle NN cord-349011-kxhpdvri 211 28 virus virus NN cord-349011-kxhpdvri 211 29 ( ( -LRB- cord-349011-kxhpdvri 211 30 SMoV SMoV NNP cord-349011-kxhpdvri 211 31 ) ) -RRB- cord-349011-kxhpdvri 211 32 . . . cord-349011-kxhpdvri 212 1 SMoV SMoV NNP cord-349011-kxhpdvri 212 2 has have VBZ cord-349011-kxhpdvri 212 3 a a DT cord-349011-kxhpdvri 212 4 bipartite bipartite JJ cord-349011-kxhpdvri 212 5 genome genome NN cord-349011-kxhpdvri 212 6 , , , cord-349011-kxhpdvri 212 7 with with IN cord-349011-kxhpdvri 212 8 each each DT cord-349011-kxhpdvri 212 9 RNA RNA NNP cord-349011-kxhpdvri 212 10 encoding encode VBG cord-349011-kxhpdvri 212 11 a a DT cord-349011-kxhpdvri 212 12 large large JJ cord-349011-kxhpdvri 212 13 polyprotein polyprotein NN cord-349011-kxhpdvri 212 14 . . . cord-349011-kxhpdvri 213 1 RNA1 RNA1 NNP cord-349011-kxhpdvri 213 2 encodes encode VBZ cord-349011-kxhpdvri 213 3 a a DT cord-349011-kxhpdvri 213 4 cysteine cysteine NN cord-349011-kxhpdvri 213 5 protease protease NN cord-349011-kxhpdvri 213 6 that that WDT cord-349011-kxhpdvri 213 7 is be VBZ cord-349011-kxhpdvri 213 8 related relate VBN cord-349011-kxhpdvri 213 9 to to IN cord-349011-kxhpdvri 213 10 the the DT cord-349011-kxhpdvri 213 11 canonical canonical JJ cord-349011-kxhpdvri 213 12 3C 3C NNP cord-349011-kxhpdvri 213 13 protease protease NN cord-349011-kxhpdvri 213 14 of of IN cord-349011-kxhpdvri 213 15 picornaviruses picornavirus NNS cord-349011-kxhpdvri 213 16 and and CC cord-349011-kxhpdvri 213 17 cleaves cleave VBZ cord-349011-kxhpdvri 213 18 at at IN cord-349011-kxhpdvri 213 19 multiple multiple JJ cord-349011-kxhpdvri 213 20 locations location NNS cord-349011-kxhpdvri 213 21 on on IN cord-349011-kxhpdvri 213 22 polyproteins polyprotein NNS cord-349011-kxhpdvri 213 23 generated generate VBN cord-349011-kxhpdvri 213 24 from from IN cord-349011-kxhpdvri 213 25 RNA1 RNA1 NNP cord-349011-kxhpdvri 213 26 and and CC cord-349011-kxhpdvri 213 27 RNA2 RNA2 NNP cord-349011-kxhpdvri 213 28 [ [ -LRB- cord-349011-kxhpdvri 213 29 57 57 CD cord-349011-kxhpdvri 213 30 ] ] -RRB- cord-349011-kxhpdvri 213 31 . . . cord-349011-kxhpdvri 214 1 Dr. Dr. NNP cord-349011-kxhpdvri 214 2 Sanfaçon Sanfaçon NNP cord-349011-kxhpdvri 214 3 and and CC cord-349011-kxhpdvri 214 4 her -PRON- PRP$ cord-349011-kxhpdvri 214 5 team team NN cord-349011-kxhpdvri 214 6 detected detect VBD cord-349011-kxhpdvri 214 7 an an DT cord-349011-kxhpdvri 214 8 additional additional JJ cord-349011-kxhpdvri 214 9 proteolytic proteolytic JJ cord-349011-kxhpdvri 214 10 activity activity NN cord-349011-kxhpdvri 214 11 associated associate VBN cord-349011-kxhpdvri 214 12 with with IN cord-349011-kxhpdvri 214 13 the the DT cord-349011-kxhpdvri 214 14 carboxy carboxy JJ cord-349011-kxhpdvri 214 15 - - HYPH cord-349011-kxhpdvri 214 16 terminal terminal NN cord-349011-kxhpdvri 214 17 domain domain NN cord-349011-kxhpdvri 214 18 of of IN cord-349011-kxhpdvri 214 19 the the DT cord-349011-kxhpdvri 214 20 RNA2 RNA2 NNP cord-349011-kxhpdvri 214 21 polyprotein polyprotein NN cord-349011-kxhpdvri 214 22 [ [ -LRB- cord-349011-kxhpdvri 214 23 58 58 CD cord-349011-kxhpdvri 214 24 ] ] -RRB- cord-349011-kxhpdvri 214 25 . . . cord-349011-kxhpdvri 215 1 Surprisingly surprisingly RB cord-349011-kxhpdvri 215 2 , , , cord-349011-kxhpdvri 215 3 mutation mutation NN cord-349011-kxhpdvri 215 4 of of IN cord-349011-kxhpdvri 215 5 conserved conserved JJ cord-349011-kxhpdvri 215 6 serine serine NN cord-349011-kxhpdvri 215 7 , , , cord-349011-kxhpdvri 215 8 cysteine cysteine NN cord-349011-kxhpdvri 215 9 , , , cord-349011-kxhpdvri 215 10 histidine histidine NN cord-349011-kxhpdvri 215 11 or or CC cord-349011-kxhpdvri 215 12 aspartic aspartic JJ cord-349011-kxhpdvri 215 13 acid acid NN cord-349011-kxhpdvri 215 14 residues residue NNS cord-349011-kxhpdvri 215 15 did do VBD cord-349011-kxhpdvri 215 16 not not RB cord-349011-kxhpdvri 215 17 affect affect VB cord-349011-kxhpdvri 215 18 this this DT cord-349011-kxhpdvri 215 19 activity activity NN cord-349011-kxhpdvri 215 20 . . . cord-349011-kxhpdvri 216 1 Instead instead RB cord-349011-kxhpdvri 216 2 , , , cord-349011-kxhpdvri 216 3 two two CD cord-349011-kxhpdvri 216 4 glutamic glutamic NN cord-349011-kxhpdvri 216 5 acid acid NN cord-349011-kxhpdvri 216 6 residues residue NNS cord-349011-kxhpdvri 216 7 were be VBD cord-349011-kxhpdvri 216 8 shown show VBN cord-349011-kxhpdvri 216 9 to to TO cord-349011-kxhpdvri 216 10 be be VB cord-349011-kxhpdvri 216 11 required require VBN cord-349011-kxhpdvri 216 12 for for IN cord-349011-kxhpdvri 216 13 polyprotein polyprotein JJ cord-349011-kxhpdvri 216 14 processing processing NN cord-349011-kxhpdvri 216 15 . . . cord-349011-kxhpdvri 217 1 N n CD cord-349011-kxhpdvri 217 2 - - HYPH cord-349011-kxhpdvri 217 3 terminal terminal NN cord-349011-kxhpdvri 217 4 sequencing sequencing NN cord-349011-kxhpdvri 217 5 by by IN cord-349011-kxhpdvri 217 6 Edman Edman NNP cord-349011-kxhpdvri 217 7 degradation degradation NN cord-349011-kxhpdvri 217 8 method method NN cord-349011-kxhpdvri 217 9 enabled enable VBD cord-349011-kxhpdvri 217 10 precise precise JJ cord-349011-kxhpdvri 217 11 mapping mapping NN cord-349011-kxhpdvri 217 12 of of IN cord-349011-kxhpdvri 217 13 two two CD cord-349011-kxhpdvri 217 14 protease protease NN cord-349011-kxhpdvri 217 15 cleavage cleavage NN cord-349011-kxhpdvri 217 16 sites site NNS cord-349011-kxhpdvri 217 17 with with IN cord-349011-kxhpdvri 217 18 the the DT cord-349011-kxhpdvri 217 19 consensus consensus NN cord-349011-kxhpdvri 217 20 sequence sequence NN cord-349011-kxhpdvri 217 21 P↓xFP P↓xFP NNP cord-349011-kxhpdvri 217 22 . . . cord-349011-kxhpdvri 218 1 Together together RB cord-349011-kxhpdvri 218 2 , , , cord-349011-kxhpdvri 218 3 these these DT cord-349011-kxhpdvri 218 4 findings finding NNS cord-349011-kxhpdvri 218 5 suggest suggest VBP cord-349011-kxhpdvri 218 6 that that IN cord-349011-kxhpdvri 218 7 SMoV SMoV NNP cord-349011-kxhpdvri 218 8 polyprotein polyprotein JJ cord-349011-kxhpdvri 218 9 processing processing NN cord-349011-kxhpdvri 218 10 requires require VBZ cord-349011-kxhpdvri 218 11 two two CD cord-349011-kxhpdvri 218 12 viral viral JJ cord-349011-kxhpdvri 218 13 proteases protease NNS cord-349011-kxhpdvri 218 14 , , , cord-349011-kxhpdvri 218 15 the the DT cord-349011-kxhpdvri 218 16 3C 3c NN cord-349011-kxhpdvri 218 17 - - HYPH cord-349011-kxhpdvri 218 18 like like JJ cord-349011-kxhpdvri 218 19 cysteine cysteine NN cord-349011-kxhpdvri 218 20 protease protease NN cord-349011-kxhpdvri 218 21 encoded encode VBN cord-349011-kxhpdvri 218 22 by by IN cord-349011-kxhpdvri 218 23 RNA1 RNA1 NNP cord-349011-kxhpdvri 218 24 , , , cord-349011-kxhpdvri 218 25 and and CC cord-349011-kxhpdvri 218 26 a a DT cord-349011-kxhpdvri 218 27 novel novel JJ cord-349011-kxhpdvri 218 28 protease protease NN cord-349011-kxhpdvri 218 29 encoded encode VBN cord-349011-kxhpdvri 218 30 by by IN cord-349011-kxhpdvri 218 31 RNA2 RNA2 NNP cord-349011-kxhpdvri 218 32 that that WDT cord-349011-kxhpdvri 218 33 features feature VBZ cord-349011-kxhpdvri 218 34 two two CD cord-349011-kxhpdvri 218 35 putative putative JJ cord-349011-kxhpdvri 218 36 glutamic glutamic NN cord-349011-kxhpdvri 218 37 acid acid NN cord-349011-kxhpdvri 218 38 residues residue NNS cord-349011-kxhpdvri 218 39 in in IN cord-349011-kxhpdvri 218 40 the the DT cord-349011-kxhpdvri 218 41 catalytic catalytic JJ cord-349011-kxhpdvri 218 42 site site NN cord-349011-kxhpdvri 218 43 . . . cord-349011-kxhpdvri 219 1 The the DT cord-349011-kxhpdvri 219 2 novel novel JJ cord-349011-kxhpdvri 219 3 protease protease NN cord-349011-kxhpdvri 219 4 domain domain NN cord-349011-kxhpdvri 219 5 is be VBZ cord-349011-kxhpdvri 219 6 only only RB cord-349011-kxhpdvri 219 7 found find VBN cord-349011-kxhpdvri 219 8 in in IN cord-349011-kxhpdvri 219 9 the the DT cord-349011-kxhpdvri 219 10 RNA2 RNA2 NNP cord-349011-kxhpdvri 219 11 polyproteins polyprotein NNS cord-349011-kxhpdvri 219 12 of of IN cord-349011-kxhpdvri 219 13 two two CD cord-349011-kxhpdvri 219 14 other other JJ cord-349011-kxhpdvri 219 15 definite definite JJ cord-349011-kxhpdvri 219 16 or or CC cord-349011-kxhpdvri 219 17 putative putative JJ cord-349011-kxhpdvri 219 18 members member NNS cord-349011-kxhpdvri 219 19 of of IN cord-349011-kxhpdvri 219 20 the the DT cord-349011-kxhpdvri 219 21 family family NN cord-349011-kxhpdvri 219 22 Secoviridae Secoviridae NNP cord-349011-kxhpdvri 219 23 , , , cord-349011-kxhpdvri 219 24 suggesting suggest VBG cord-349011-kxhpdvri 219 25 that that IN cord-349011-kxhpdvri 219 26 it -PRON- PRP cord-349011-kxhpdvri 219 27 was be VBD cord-349011-kxhpdvri 219 28 recently recently RB cord-349011-kxhpdvri 219 29 acquired acquire VBN cord-349011-kxhpdvri 219 30 . . . cord-349011-kxhpdvri 220 1 The the DT cord-349011-kxhpdvri 220 2 " " `` cord-349011-kxhpdvri 220 3 Viruses Viruses NNPS cord-349011-kxhpdvri 220 4 of of IN cord-349011-kxhpdvri 220 5 Flora Flora NNP cord-349011-kxhpdvri 220 6 and and CC cord-349011-kxhpdvri 220 7 Fauna Fauna NNP cord-349011-kxhpdvri 220 8 " " '' cord-349011-kxhpdvri 220 9 session session NN cord-349011-kxhpdvri 220 10 also also RB cord-349011-kxhpdvri 220 11 included include VBD cord-349011-kxhpdvri 220 12 presentations presentation NNS cord-349011-kxhpdvri 220 13 from from IN cord-349011-kxhpdvri 220 14 the the DT cord-349011-kxhpdvri 220 15 following follow VBG cord-349011-kxhpdvri 220 16 trainees trainee NNS cord-349011-kxhpdvri 220 17 : : : cord-349011-kxhpdvri 221 1 Shuang Shuang NNP cord-349011-kxhpdvri 221 2 Yang Yang NNP cord-349011-kxhpdvri 221 3 ( ( -LRB- cord-349011-kxhpdvri 221 4 University University NNP cord-349011-kxhpdvri 221 5 of of IN cord-349011-kxhpdvri 221 6 British British NNP cord-349011-kxhpdvri 221 7 Columbia Columbia NNP cord-349011-kxhpdvri 221 8 ) ) -RRB- cord-349011-kxhpdvri 221 9 who who WP cord-349011-kxhpdvri 221 10 described describe VBD cord-349011-kxhpdvri 221 11 a a DT cord-349011-kxhpdvri 221 12 unique unique JJ cord-349011-kxhpdvri 221 13 nuclear nuclear JJ cord-349011-kxhpdvri 221 14 entry entry NN cord-349011-kxhpdvri 221 15 pathway pathway NN cord-349011-kxhpdvri 221 16 for for IN cord-349011-kxhpdvri 221 17 parvoviruses parvovirus NNS cord-349011-kxhpdvri 221 18 , , , cord-349011-kxhpdvri 221 19 Gerard Gerard NNP cord-349011-kxhpdvri 221 20 Gaspard Gaspard NNP cord-349011-kxhpdvri 221 21 ( ( -LRB- cord-349011-kxhpdvri 221 22 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 221 23 University University NNP cord-349011-kxhpdvri 221 24 ) ) -RRB- cord-349011-kxhpdvri 221 25 who who WP cord-349011-kxhpdvri 221 26 presented present VBD cord-349011-kxhpdvri 221 27 mechanistic mechanistic JJ cord-349011-kxhpdvri 221 28 studies study NNS cord-349011-kxhpdvri 221 29 of of IN cord-349011-kxhpdvri 221 30 the the DT cord-349011-kxhpdvri 221 31 reptilian reptilian JJ cord-349011-kxhpdvri 221 32 reovirus reovirus NNP cord-349011-kxhpdvri 221 33 p14 p14 NNP cord-349011-kxhpdvri 221 34 fusion fusion NN cord-349011-kxhpdvri 221 35 protein protein NN cord-349011-kxhpdvri 221 36 , , , cord-349011-kxhpdvri 221 37 and and CC cord-349011-kxhpdvri 221 38 Jared Jared NNP cord-349011-kxhpdvri 221 39 Rowell Rowell NNP cord-349011-kxhpdvri 221 40 ( ( -LRB- cord-349011-kxhpdvri 221 41 University University NNP cord-349011-kxhpdvri 221 42 of of IN cord-349011-kxhpdvri 221 43 Calgary Calgary NNP cord-349011-kxhpdvri 221 44 ) ) -RRB- cord-349011-kxhpdvri 221 45 who who WP cord-349011-kxhpdvri 221 46 presented present VBD cord-349011-kxhpdvri 221 47 studies study NNS cord-349011-kxhpdvri 221 48 of of IN cord-349011-kxhpdvri 221 49 cell cell NN cord-349011-kxhpdvri 221 50 fate fate NN cord-349011-kxhpdvri 221 51 during during IN cord-349011-kxhpdvri 221 52 porcine porcine JJ cord-349011-kxhpdvri 221 53 circovirus-2 circovirus-2 NNP cord-349011-kxhpdvri 221 54 infection infection NN cord-349011-kxhpdvri 221 55 . . . cord-349011-kxhpdvri 222 1 During during IN cord-349011-kxhpdvri 222 2 the the DT cord-349011-kxhpdvri 222 3 break break NN cord-349011-kxhpdvri 222 4 following follow VBG cord-349011-kxhpdvri 222 5 this this DT cord-349011-kxhpdvri 222 6 session session NN cord-349011-kxhpdvri 222 7 , , , cord-349011-kxhpdvri 222 8 everyone everyone NN cord-349011-kxhpdvri 222 9 assembled assemble VBD cord-349011-kxhpdvri 222 10 in in IN cord-349011-kxhpdvri 222 11 the the DT cord-349011-kxhpdvri 222 12 courtyard courtyard NN cord-349011-kxhpdvri 222 13 for for IN cord-349011-kxhpdvri 222 14 a a DT cord-349011-kxhpdvri 222 15 group group NN cord-349011-kxhpdvri 222 16 photo photo NN cord-349011-kxhpdvri 222 17 ( ( -LRB- cord-349011-kxhpdvri 222 18 Figure figure NN cord-349011-kxhpdvri 222 19 4 4 CD cord-349011-kxhpdvri 222 20 ) ) -RRB- cord-349011-kxhpdvri 222 21 . . . cord-349011-kxhpdvri 223 1 Viruses virus NNS cord-349011-kxhpdvri 223 2 2019 2019 CD cord-349011-kxhpdvri 223 3 , , , cord-349011-kxhpdvri 223 4 11 11 CD cord-349011-kxhpdvri 223 5 , , , cord-349011-kxhpdvri 223 6 x x NN cord-349011-kxhpdvri 223 7 FOR for IN cord-349011-kxhpdvri 223 8 PEER peer NN cord-349011-kxhpdvri 223 9 REVIEW REVIEW NNP cord-349011-kxhpdvri 223 10 11 11 CD cord-349011-kxhpdvri 223 11 of of IN cord-349011-kxhpdvri 223 12 17 17 CD cord-349011-kxhpdvri 223 13 required require VBN cord-349011-kxhpdvri 223 14 for for IN cord-349011-kxhpdvri 223 15 polyprotein polyprotein JJ cord-349011-kxhpdvri 223 16 processing processing NN cord-349011-kxhpdvri 223 17 . . . cord-349011-kxhpdvri 224 1 N n CD cord-349011-kxhpdvri 224 2 - - HYPH cord-349011-kxhpdvri 224 3 terminal terminal NN cord-349011-kxhpdvri 224 4 sequencing sequencing NN cord-349011-kxhpdvri 224 5 by by IN cord-349011-kxhpdvri 224 6 Edman Edman NNP cord-349011-kxhpdvri 224 7 degradation degradation NN cord-349011-kxhpdvri 224 8 method method NN cord-349011-kxhpdvri 224 9 enabled enable VBD cord-349011-kxhpdvri 224 10 precise precise JJ cord-349011-kxhpdvri 224 11 mapping mapping NN cord-349011-kxhpdvri 224 12 of of IN cord-349011-kxhpdvri 224 13 two two CD cord-349011-kxhpdvri 224 14 protease protease NN cord-349011-kxhpdvri 224 15 cleavage cleavage NN cord-349011-kxhpdvri 224 16 sites site NNS cord-349011-kxhpdvri 224 17 with with IN cord-349011-kxhpdvri 224 18 the the DT cord-349011-kxhpdvri 224 19 consensus consensus NN cord-349011-kxhpdvri 224 20 sequence sequence NN cord-349011-kxhpdvri 224 21 P↓xFP P↓xFP NNP cord-349011-kxhpdvri 224 22 . . . cord-349011-kxhpdvri 225 1 Together together RB cord-349011-kxhpdvri 225 2 , , , cord-349011-kxhpdvri 225 3 these these DT cord-349011-kxhpdvri 225 4 findings finding NNS cord-349011-kxhpdvri 225 5 suggest suggest VBP cord-349011-kxhpdvri 225 6 that that IN cord-349011-kxhpdvri 225 7 SMoV SMoV NNP cord-349011-kxhpdvri 225 8 polyprotein polyprotein JJ cord-349011-kxhpdvri 225 9 processing processing NN cord-349011-kxhpdvri 225 10 requires require VBZ cord-349011-kxhpdvri 225 11 two two CD cord-349011-kxhpdvri 225 12 viral viral JJ cord-349011-kxhpdvri 225 13 proteases protease NNS cord-349011-kxhpdvri 225 14 , , , cord-349011-kxhpdvri 225 15 the the DT cord-349011-kxhpdvri 225 16 3C 3c NN cord-349011-kxhpdvri 225 17 - - HYPH cord-349011-kxhpdvri 225 18 like like JJ cord-349011-kxhpdvri 225 19 cysteine cysteine NN cord-349011-kxhpdvri 225 20 protease protease NN cord-349011-kxhpdvri 225 21 encoded encode VBN cord-349011-kxhpdvri 225 22 by by IN cord-349011-kxhpdvri 225 23 RNA1 RNA1 NNP cord-349011-kxhpdvri 225 24 , , , cord-349011-kxhpdvri 225 25 and and CC cord-349011-kxhpdvri 225 26 a a DT cord-349011-kxhpdvri 225 27 novel novel JJ cord-349011-kxhpdvri 225 28 protease protease NN cord-349011-kxhpdvri 225 29 encoded encode VBN cord-349011-kxhpdvri 225 30 by by IN cord-349011-kxhpdvri 225 31 RNA2 RNA2 NNP cord-349011-kxhpdvri 225 32 that that WDT cord-349011-kxhpdvri 225 33 features feature VBZ cord-349011-kxhpdvri 225 34 two two CD cord-349011-kxhpdvri 225 35 putative putative JJ cord-349011-kxhpdvri 225 36 glutamic glutamic NN cord-349011-kxhpdvri 225 37 acid acid NN cord-349011-kxhpdvri 225 38 residues residue NNS cord-349011-kxhpdvri 225 39 in in IN cord-349011-kxhpdvri 225 40 the the DT cord-349011-kxhpdvri 225 41 catalytic catalytic JJ cord-349011-kxhpdvri 225 42 site site NN cord-349011-kxhpdvri 225 43 . . . cord-349011-kxhpdvri 226 1 The the DT cord-349011-kxhpdvri 226 2 novel novel JJ cord-349011-kxhpdvri 226 3 protease protease NN cord-349011-kxhpdvri 226 4 domain domain NN cord-349011-kxhpdvri 226 5 is be VBZ cord-349011-kxhpdvri 226 6 only only RB cord-349011-kxhpdvri 226 7 found find VBN cord-349011-kxhpdvri 226 8 in in IN cord-349011-kxhpdvri 226 9 the the DT cord-349011-kxhpdvri 226 10 RNA2 RNA2 NNP cord-349011-kxhpdvri 226 11 polyproteins polyprotein NNS cord-349011-kxhpdvri 226 12 of of IN cord-349011-kxhpdvri 226 13 two two CD cord-349011-kxhpdvri 226 14 other other JJ cord-349011-kxhpdvri 226 15 definite definite JJ cord-349011-kxhpdvri 226 16 or or CC cord-349011-kxhpdvri 226 17 putative putative JJ cord-349011-kxhpdvri 226 18 members member NNS cord-349011-kxhpdvri 226 19 of of IN cord-349011-kxhpdvri 226 20 the the DT cord-349011-kxhpdvri 226 21 family family NN cord-349011-kxhpdvri 226 22 Secoviridae Secoviridae NNP cord-349011-kxhpdvri 226 23 , , , cord-349011-kxhpdvri 226 24 suggesting suggest VBG cord-349011-kxhpdvri 226 25 that that IN cord-349011-kxhpdvri 226 26 it -PRON- PRP cord-349011-kxhpdvri 226 27 was be VBD cord-349011-kxhpdvri 226 28 recently recently RB cord-349011-kxhpdvri 226 29 acquired acquire VBN cord-349011-kxhpdvri 226 30 . . . cord-349011-kxhpdvri 227 1 The the DT cord-349011-kxhpdvri 227 2 " " `` cord-349011-kxhpdvri 227 3 Viruses Viruses NNPS cord-349011-kxhpdvri 227 4 of of IN cord-349011-kxhpdvri 227 5 Flora Flora NNP cord-349011-kxhpdvri 227 6 and and CC cord-349011-kxhpdvri 227 7 Fauna Fauna NNP cord-349011-kxhpdvri 227 8 " " '' cord-349011-kxhpdvri 227 9 session session NN cord-349011-kxhpdvri 227 10 also also RB cord-349011-kxhpdvri 227 11 included include VBD cord-349011-kxhpdvri 227 12 presentations presentation NNS cord-349011-kxhpdvri 227 13 from from IN cord-349011-kxhpdvri 227 14 the the DT cord-349011-kxhpdvri 227 15 following follow VBG cord-349011-kxhpdvri 227 16 trainees trainee NNS cord-349011-kxhpdvri 227 17 : : : cord-349011-kxhpdvri 228 1 Shuang Shuang NNP cord-349011-kxhpdvri 228 2 Yang Yang NNP cord-349011-kxhpdvri 228 3 ( ( -LRB- cord-349011-kxhpdvri 228 4 University University NNP cord-349011-kxhpdvri 228 5 of of IN cord-349011-kxhpdvri 228 6 British British NNP cord-349011-kxhpdvri 228 7 Columbia Columbia NNP cord-349011-kxhpdvri 228 8 ) ) -RRB- cord-349011-kxhpdvri 228 9 who who WP cord-349011-kxhpdvri 228 10 described describe VBD cord-349011-kxhpdvri 228 11 a a DT cord-349011-kxhpdvri 228 12 unique unique JJ cord-349011-kxhpdvri 228 13 nuclear nuclear JJ cord-349011-kxhpdvri 228 14 entry entry NN cord-349011-kxhpdvri 228 15 pathway pathway NN cord-349011-kxhpdvri 228 16 for for IN cord-349011-kxhpdvri 228 17 parvoviruses parvovirus NNS cord-349011-kxhpdvri 228 18 , , , cord-349011-kxhpdvri 228 19 Gerard Gerard NNP cord-349011-kxhpdvri 228 20 Gaspard Gaspard NNP cord-349011-kxhpdvri 228 21 ( ( -LRB- cord-349011-kxhpdvri 228 22 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 228 23 University University NNP cord-349011-kxhpdvri 228 24 ) ) -RRB- cord-349011-kxhpdvri 228 25 who who WP cord-349011-kxhpdvri 228 26 presented present VBD cord-349011-kxhpdvri 228 27 mechanistic mechanistic JJ cord-349011-kxhpdvri 228 28 studies study NNS cord-349011-kxhpdvri 228 29 of of IN cord-349011-kxhpdvri 228 30 the the DT cord-349011-kxhpdvri 228 31 reptilian reptilian JJ cord-349011-kxhpdvri 228 32 reovirus reovirus NNP cord-349011-kxhpdvri 228 33 p14 p14 NNP cord-349011-kxhpdvri 228 34 fusion fusion NN cord-349011-kxhpdvri 228 35 protein protein NN cord-349011-kxhpdvri 228 36 , , , cord-349011-kxhpdvri 228 37 and and CC cord-349011-kxhpdvri 228 38 Jared Jared NNP cord-349011-kxhpdvri 228 39 Rowell Rowell NNP cord-349011-kxhpdvri 228 40 ( ( -LRB- cord-349011-kxhpdvri 228 41 University University NNP cord-349011-kxhpdvri 228 42 of of IN cord-349011-kxhpdvri 228 43 Calgary Calgary NNP cord-349011-kxhpdvri 228 44 ) ) -RRB- cord-349011-kxhpdvri 228 45 who who WP cord-349011-kxhpdvri 228 46 presented present VBD cord-349011-kxhpdvri 228 47 studies study NNS cord-349011-kxhpdvri 228 48 of of IN cord-349011-kxhpdvri 228 49 cell cell NN cord-349011-kxhpdvri 228 50 fate fate NN cord-349011-kxhpdvri 228 51 during during IN cord-349011-kxhpdvri 228 52 porcine porcine JJ cord-349011-kxhpdvri 228 53 circovirus-2 circovirus-2 NNP cord-349011-kxhpdvri 228 54 infection infection NN cord-349011-kxhpdvri 228 55 . . . cord-349011-kxhpdvri 229 1 During during IN cord-349011-kxhpdvri 229 2 the the DT cord-349011-kxhpdvri 229 3 break break NN cord-349011-kxhpdvri 229 4 following follow VBG cord-349011-kxhpdvri 229 5 this this DT cord-349011-kxhpdvri 229 6 session session NN cord-349011-kxhpdvri 229 7 , , , cord-349011-kxhpdvri 229 8 everyone everyone NN cord-349011-kxhpdvri 229 9 assembled assemble VBD cord-349011-kxhpdvri 229 10 in in IN cord-349011-kxhpdvri 229 11 the the DT cord-349011-kxhpdvri 229 12 courtyard courtyard NN cord-349011-kxhpdvri 229 13 for for IN cord-349011-kxhpdvri 229 14 a a DT cord-349011-kxhpdvri 229 15 group group NN cord-349011-kxhpdvri 229 16 photo photo NN cord-349011-kxhpdvri 229 17 ( ( -LRB- cord-349011-kxhpdvri 229 18 Figure figure NN cord-349011-kxhpdvri 229 19 4 4 CD cord-349011-kxhpdvri 229 20 ) ) -RRB- cord-349011-kxhpdvri 229 21 . . . cord-349011-kxhpdvri 229 22 _SP cord-349011-kxhpdvri 230 1 Dr. Dr. NNP cord-349011-kxhpdvri 230 2 Karen Karen NNP cord-349011-kxhpdvri 230 3 Mossman Mossman NNP cord-349011-kxhpdvri 230 4 ( ( -LRB- cord-349011-kxhpdvri 230 5 McMaster McMaster NNP cord-349011-kxhpdvri 230 6 University University NNP cord-349011-kxhpdvri 230 7 ) ) -RRB- cord-349011-kxhpdvri 230 8 chaired chair VBD cord-349011-kxhpdvri 230 9 the the DT cord-349011-kxhpdvri 230 10 final final JJ cord-349011-kxhpdvri 230 11 symposium symposium NN cord-349011-kxhpdvri 230 12 session session NN cord-349011-kxhpdvri 230 13 on on IN cord-349011-kxhpdvri 230 14 " " `` cord-349011-kxhpdvri 230 15 Antiviral Antiviral NNP cord-349011-kxhpdvri 230 16 Innate Innate NNP cord-349011-kxhpdvri 230 17 Immunity Immunity NNP cord-349011-kxhpdvri 230 18 " " '' cord-349011-kxhpdvri 230 19 , , , cord-349011-kxhpdvri 230 20 which which WDT cord-349011-kxhpdvri 230 21 was be VBD cord-349011-kxhpdvri 230 22 led lead VBN cord-349011-kxhpdvri 230 23 off off RP cord-349011-kxhpdvri 230 24 by by IN cord-349011-kxhpdvri 230 25 her -PRON- PRP$ cord-349011-kxhpdvri 230 26 former former JJ cord-349011-kxhpdvri 230 27 post post JJ cord-349011-kxhpdvri 230 28 - - JJ cord-349011-kxhpdvri 230 29 doctoral doctoral JJ cord-349011-kxhpdvri 230 30 fellow fellow NN cord-349011-kxhpdvri 230 31 Dr. Dr. NNP cord-349011-kxhpdvri 230 32 Stephanie Stephanie NNP cord-349011-kxhpdvri 230 33 DeWitte DeWitte NNP cord-349011-kxhpdvri 230 34 - - HYPH cord-349011-kxhpdvri 230 35 Orr Orr NNP cord-349011-kxhpdvri 230 36 ( ( -LRB- cord-349011-kxhpdvri 230 37 Wilfrid Wilfrid NNP cord-349011-kxhpdvri 230 38 Laurier Laurier NNP cord-349011-kxhpdvri 230 39 University University NNP cord-349011-kxhpdvri 230 40 ) ) -RRB- cord-349011-kxhpdvri 230 41 who who WP cord-349011-kxhpdvri 230 42 discussed discuss VBD cord-349011-kxhpdvri 230 43 roles role NNS cord-349011-kxhpdvri 230 44 for for IN cord-349011-kxhpdvri 230 45 class class NN cord-349011-kxhpdvri 230 46 A a DT cord-349011-kxhpdvri 230 47 scavenger scavenger NN cord-349011-kxhpdvri 230 48 receptors receptor NNS cord-349011-kxhpdvri 230 49 ( ( -LRB- cord-349011-kxhpdvri 230 50 SR SR NNP cord-349011-kxhpdvri 230 51 - - : cord-349011-kxhpdvri 230 52 As as IN cord-349011-kxhpdvri 230 53 ) ) -RRB- cord-349011-kxhpdvri 230 54 in in IN cord-349011-kxhpdvri 230 55 innate innate JJ cord-349011-kxhpdvri 230 56 antiviral antiviral JJ cord-349011-kxhpdvri 230 57 immunity immunity NN cord-349011-kxhpdvri 230 58 in in IN cord-349011-kxhpdvri 230 59 lower low JJR cord-349011-kxhpdvri 230 60 vertebrates vertebrate NNS cord-349011-kxhpdvri 230 61 . . . cord-349011-kxhpdvri 231 1 In in IN cord-349011-kxhpdvri 231 2 mammals mammal NNS cord-349011-kxhpdvri 231 3 the the DT cord-349011-kxhpdvri 231 4 SR SR NNP cord-349011-kxhpdvri 231 5 - - : cord-349011-kxhpdvri 231 6 As as IN cord-349011-kxhpdvri 231 7 include include VBP cord-349011-kxhpdvri 231 8 five five CD cord-349011-kxhpdvri 231 9 family family NN cord-349011-kxhpdvri 231 10 members member NNS cord-349011-kxhpdvri 231 11 ( ( -LRB- cord-349011-kxhpdvri 231 12 SR SR NNP cord-349011-kxhpdvri 231 13 - - HYPH cord-349011-kxhpdvri 231 14 AI AI NNP cord-349011-kxhpdvri 231 15 , , , cord-349011-kxhpdvri 231 16 MARCO MARCO NNP cord-349011-kxhpdvri 231 17 , , , cord-349011-kxhpdvri 231 18 SCARA3 SCARA3 NNP cord-349011-kxhpdvri 231 19 , , , cord-349011-kxhpdvri 231 20 SCARA4 scara4 NN cord-349011-kxhpdvri 231 21 and and CC cord-349011-kxhpdvri 231 22 SCARA5 scara5 NN cord-349011-kxhpdvri 231 23 ) ) -RRB- cord-349011-kxhpdvri 231 24 that that WDT cord-349011-kxhpdvri 231 25 play play VBP cord-349011-kxhpdvri 231 26 diverse diverse JJ cord-349011-kxhpdvri 231 27 roles role NNS cord-349011-kxhpdvri 231 28 in in IN cord-349011-kxhpdvri 231 29 immunity immunity NN cord-349011-kxhpdvri 231 30 , , , cord-349011-kxhpdvri 231 31 aiding aid VBG cord-349011-kxhpdvri 231 32 macrophage macrophage NN cord-349011-kxhpdvri 231 33 clearance clearance NN cord-349011-kxhpdvri 231 34 of of IN cord-349011-kxhpdvri 231 35 pathogens pathogen NNS cord-349011-kxhpdvri 231 36 and and CC cord-349011-kxhpdvri 231 37 apoptotic apoptotic JJ cord-349011-kxhpdvri 231 38 cells cell NNS cord-349011-kxhpdvri 231 39 , , , cord-349011-kxhpdvri 231 40 and and CC cord-349011-kxhpdvri 231 41 acting act VBG cord-349011-kxhpdvri 231 42 as as IN cord-349011-kxhpdvri 231 43 receptors receptor NNS cord-349011-kxhpdvri 231 44 for for IN cord-349011-kxhpdvri 231 45 immune immune NN cord-349011-kxhpdvri 231 46 - - HYPH cord-349011-kxhpdvri 231 47 stimulating stimulate VBG cord-349011-kxhpdvri 231 48 molecules molecule NNS cord-349011-kxhpdvri 231 49 . . . cord-349011-kxhpdvri 232 1 They -PRON- PRP cord-349011-kxhpdvri 232 2 have have VBP cord-349011-kxhpdvri 232 3 also also RB cord-349011-kxhpdvri 232 4 been be VBN cord-349011-kxhpdvri 232 5 shown show VBN cord-349011-kxhpdvri 232 6 to to TO cord-349011-kxhpdvri 232 7 serve serve VB cord-349011-kxhpdvri 232 8 as as IN cord-349011-kxhpdvri 232 9 virus virus NN cord-349011-kxhpdvri 232 10 receptors receptor NNS cord-349011-kxhpdvri 232 11 . . . cord-349011-kxhpdvri 233 1 Notwithstanding notwithstanding IN cord-349011-kxhpdvri 233 2 how how WRB cord-349011-kxhpdvri 233 3 important important JJ cord-349011-kxhpdvri 233 4 these these DT cord-349011-kxhpdvri 233 5 receptors receptor NNS cord-349011-kxhpdvri 233 6 are be VBP cord-349011-kxhpdvri 233 7 to to TO cord-349011-kxhpdvri 233 8 host host VB cord-349011-kxhpdvri 233 9 immunity immunity NN cord-349011-kxhpdvri 233 10 , , , cord-349011-kxhpdvri 233 11 little little JJ cord-349011-kxhpdvri 233 12 is be VBZ cord-349011-kxhpdvri 233 13 known know VBN cord-349011-kxhpdvri 233 14 regarding regard VBG cord-349011-kxhpdvri 233 15 SR SR NNP cord-349011-kxhpdvri 233 16 - - HYPH cord-349011-kxhpdvri 233 17 A a DT cord-349011-kxhpdvri 233 18 function function NN cord-349011-kxhpdvri 233 19 in in IN cord-349011-kxhpdvri 233 20 lower low JJR cord-349011-kxhpdvri 233 21 vertebrates vertebrate NNS cord-349011-kxhpdvri 233 22 . . . cord-349011-kxhpdvri 234 1 Dr. Dr. NNP cord-349011-kxhpdvri 234 2 DeWitte DeWitte NNP cord-349011-kxhpdvri 234 3 - - HYPH cord-349011-kxhpdvri 234 4 Orr Orr NNP cord-349011-kxhpdvri 234 5 presented present VBD cord-349011-kxhpdvri 234 6 her -PRON- PRP$ cord-349011-kxhpdvri 234 7 findings finding NNS cord-349011-kxhpdvri 234 8 to to IN cord-349011-kxhpdvri 234 9 date date NN cord-349011-kxhpdvri 234 10 regarding regard VBG cord-349011-kxhpdvri 234 11 SR SR NNP cord-349011-kxhpdvri 234 12 - - : cord-349011-kxhpdvri 234 13 As as IN cord-349011-kxhpdvri 234 14 and and CC cord-349011-kxhpdvri 234 15 their -PRON- PRP$ cord-349011-kxhpdvri 234 16 functions function NNS cord-349011-kxhpdvri 234 17 in in IN cord-349011-kxhpdvri 234 18 fish fish NN cord-349011-kxhpdvri 234 19 and and CC cord-349011-kxhpdvri 234 20 frogs frog NNS cord-349011-kxhpdvri 234 21 . . . cord-349011-kxhpdvri 235 1 Dr. Dr. NNP cord-349011-kxhpdvri 235 2 DeWitte DeWitte NNP cord-349011-kxhpdvri 235 3 - - HYPH cord-349011-kxhpdvri 235 4 Orr Orr NNP cord-349011-kxhpdvri 235 5 has have VBZ cord-349011-kxhpdvri 235 6 identified identify VBN cord-349011-kxhpdvri 235 7 MARCO MARCO NNP cord-349011-kxhpdvri 235 8 , , , cord-349011-kxhpdvri 235 9 SCARA3 SCARA3 NNP cord-349011-kxhpdvri 235 10 , , , cord-349011-kxhpdvri 235 11 SCARA4 scara4 NN cord-349011-kxhpdvri 235 12 and and CC cord-349011-kxhpdvri 235 13 SCARA5 scara5 NN cord-349011-kxhpdvri 235 14 sequences sequence NNS cord-349011-kxhpdvri 235 15 from from IN cord-349011-kxhpdvri 235 16 rainbow rainbow NN cord-349011-kxhpdvri 235 17 trout trout NNP cord-349011-kxhpdvri 235 18 [ [ -LRB- cord-349011-kxhpdvri 235 19 59 59 CD cord-349011-kxhpdvri 235 20 , , , cord-349011-kxhpdvri 235 21 60 60 CD cord-349011-kxhpdvri 235 22 ] ] -RRB- cord-349011-kxhpdvri 235 23 . . . cord-349011-kxhpdvri 236 1 These these DT cord-349011-kxhpdvri 236 2 SR SR NNP cord-349011-kxhpdvri 236 3 - - : cord-349011-kxhpdvri 236 4 As as IN cord-349011-kxhpdvri 236 5 appear appear VBP cord-349011-kxhpdvri 236 6 to to TO cord-349011-kxhpdvri 236 7 be be VB cord-349011-kxhpdvri 236 8 functional functional JJ cord-349011-kxhpdvri 236 9 in in IN cord-349011-kxhpdvri 236 10 rainbow rainbow NN cord-349011-kxhpdvri 236 11 trout trout NNS cord-349011-kxhpdvri 236 12 , , , cord-349011-kxhpdvri 236 13 and and CC cord-349011-kxhpdvri 236 14 act act VB cord-349011-kxhpdvri 236 15 as as IN cord-349011-kxhpdvri 236 16 surface surface NN cord-349011-kxhpdvri 236 17 receptors receptor NNS cord-349011-kxhpdvri 236 18 for for IN cord-349011-kxhpdvri 236 19 double double RB cord-349011-kxhpdvri 236 20 - - HYPH cord-349011-kxhpdvri 236 21 stranded strand VBN cord-349011-kxhpdvri 236 22 RNA RNA NNP cord-349011-kxhpdvri 236 23 ( ( -LRB- cord-349011-kxhpdvri 236 24 dsRNA dsrna NN cord-349011-kxhpdvri 236 25 ) ) -RRB- cord-349011-kxhpdvri 236 26 , , , cord-349011-kxhpdvri 236 27 a a DT cord-349011-kxhpdvri 236 28 virus virus NN cord-349011-kxhpdvri 236 29 - - HYPH cord-349011-kxhpdvri 236 30 derived derive VBN cord-349011-kxhpdvri 236 31 innate innate JJ cord-349011-kxhpdvri 236 32 immune immune JJ cord-349011-kxhpdvri 236 33 stimulant stimulant NN cord-349011-kxhpdvri 236 34 [ [ -LRB- cord-349011-kxhpdvri 236 35 61 61 CD cord-349011-kxhpdvri 236 36 ] ] -RRB- cord-349011-kxhpdvri 236 37 . . . cord-349011-kxhpdvri 237 1 Interestingly interestingly RB cord-349011-kxhpdvri 237 2 , , , cord-349011-kxhpdvri 237 3 MARCO MARCO NNP cord-349011-kxhpdvri 237 4 does do VBZ cord-349011-kxhpdvri 237 5 not not RB cord-349011-kxhpdvri 237 6 appear appear VB cord-349011-kxhpdvri 237 7 to to TO cord-349011-kxhpdvri 237 8 bind bind VB cord-349011-kxhpdvri 237 9 dsRNA dsrna NN cord-349011-kxhpdvri 237 10 , , , cord-349011-kxhpdvri 237 11 a a DT cord-349011-kxhpdvri 237 12 unique unique JJ cord-349011-kxhpdvri 237 13 finding finding NN cord-349011-kxhpdvri 237 14 in in IN cord-349011-kxhpdvri 237 15 vertebrates vertebrate NNS cord-349011-kxhpdvri 237 16 [ [ -LRB- cord-349011-kxhpdvri 237 17 59 59 CD cord-349011-kxhpdvri 237 18 ] ] -RRB- cord-349011-kxhpdvri 237 19 . . . cord-349011-kxhpdvri 238 1 SR- SR- NNP cord-349011-kxhpdvri 239 1 As as IN cord-349011-kxhpdvri 239 2 appear appear VB cord-349011-kxhpdvri 239 3 to to TO cord-349011-kxhpdvri 239 4 be be VB cord-349011-kxhpdvri 239 5 surface surface NN cord-349011-kxhpdvri 239 6 receptors receptor NNS cord-349011-kxhpdvri 239 7 in in IN cord-349011-kxhpdvri 239 8 amphibian amphibian NN cord-349011-kxhpdvri 239 9 cells cell NNS cord-349011-kxhpdvri 239 10 as as RB cord-349011-kxhpdvri 239 11 well well RB cord-349011-kxhpdvri 239 12 , , , cord-349011-kxhpdvri 239 13 as as IN cord-349011-kxhpdvri 239 14 Dr. Dr. NNP cord-349011-kxhpdvri 239 15 DeWitte DeWitte NNP cord-349011-kxhpdvri 239 16 - - HYPH cord-349011-kxhpdvri 239 17 Orr Orr NNP cord-349011-kxhpdvri 239 18 presented present VBD cord-349011-kxhpdvri 239 19 her -PRON- PRP$ cord-349011-kxhpdvri 239 20 findings finding NNS cord-349011-kxhpdvri 239 21 regarding regard VBG cord-349011-kxhpdvri 239 22 SR SR NNP cord-349011-kxhpdvri 239 23 - - HYPH cord-349011-kxhpdvri 239 24 A A NNP cord-349011-kxhpdvri 239 25 mediated mediate VBN cord-349011-kxhpdvri 239 26 dsRNA dsrna NN cord-349011-kxhpdvri 239 27 responses response NNS cord-349011-kxhpdvri 239 28 in in IN cord-349011-kxhpdvri 239 29 the the DT cord-349011-kxhpdvri 239 30 American american JJ cord-349011-kxhpdvri 239 31 toad toad NN cord-349011-kxhpdvri 239 32 cell cell NN cord-349011-kxhpdvri 239 33 line line NN cord-349011-kxhpdvri 239 34 , , , cord-349011-kxhpdvri 239 35 BufoTad BufoTad NNP cord-349011-kxhpdvri 239 36 [ [ -LRB- cord-349011-kxhpdvri 239 37 62 62 CD cord-349011-kxhpdvri 239 38 ] ] -RRB- cord-349011-kxhpdvri 239 39 . . . cord-349011-kxhpdvri 240 1 In in IN cord-349011-kxhpdvri 240 2 addition addition NN cord-349011-kxhpdvri 240 3 to to TO cord-349011-kxhpdvri 240 4 function function VB cord-349011-kxhpdvri 240 5 studies study NNS cord-349011-kxhpdvri 240 6 , , , cord-349011-kxhpdvri 240 7 the the DT cord-349011-kxhpdvri 240 8 DeWitte DeWitte NNP cord-349011-kxhpdvri 240 9 - - HYPH cord-349011-kxhpdvri 240 10 Orr Orr NNP cord-349011-kxhpdvri 240 11 group group NN cord-349011-kxhpdvri 240 12 has have VBZ cord-349011-kxhpdvri 240 13 identified identify VBN cord-349011-kxhpdvri 240 14 a a DT cord-349011-kxhpdvri 240 15 cell cell NN cord-349011-kxhpdvri 240 16 line line NN cord-349011-kxhpdvri 240 17 derived derive VBN cord-349011-kxhpdvri 240 18 from from IN cord-349011-kxhpdvri 240 19 Chinook Chinook NNP cord-349011-kxhpdvri 240 20 salmon salmon NN cord-349011-kxhpdvri 240 21 ( ( -LRB- cord-349011-kxhpdvri 240 22 CHSE-214 CHSE-214 NNP cord-349011-kxhpdvri 240 23 ) ) -RRB- cord-349011-kxhpdvri 240 24 that that WDT cord-349011-kxhpdvri 240 25 appears appear VBZ cord-349011-kxhpdvri 240 26 to to TO cord-349011-kxhpdvri 240 27 lack lack VB cord-349011-kxhpdvri 240 28 functional functional JJ cord-349011-kxhpdvri 240 29 SR SR NNP cord-349011-kxhpdvri 240 30 - - : cord-349011-kxhpdvri 240 31 As As NNP cord-349011-kxhpdvri 240 32 and and CC cord-349011-kxhpdvri 240 33 can can MD cord-349011-kxhpdvri 240 34 be be VB cord-349011-kxhpdvri 240 35 used use VBN cord-349011-kxhpdvri 240 36 as as IN cord-349011-kxhpdvri 240 37 a a DT cord-349011-kxhpdvri 240 38 model model NN cord-349011-kxhpdvri 240 39 for for IN cord-349011-kxhpdvri 240 40 SR SR NNP cord-349011-kxhpdvri 240 41 - - HYPH cord-349011-kxhpdvri 240 42 A A NNP cord-349011-kxhpdvri 240 43 / / SYM cord-349011-kxhpdvri 240 44 dsRNA dsrna NN cord-349011-kxhpdvri 240 45 binding bind VBG cord-349011-kxhpdvri 240 46 [ [ -LRB- cord-349011-kxhpdvri 240 47 63 63 CD cord-349011-kxhpdvri 240 48 ] ] -RRB- cord-349011-kxhpdvri 240 49 . . . cord-349011-kxhpdvri 241 1 Finally finally RB cord-349011-kxhpdvri 241 2 , , , cord-349011-kxhpdvri 241 3 she -PRON- PRP cord-349011-kxhpdvri 241 4 presented present VBD cord-349011-kxhpdvri 241 5 evidence evidence NN cord-349011-kxhpdvri 241 6 that that IN cord-349011-kxhpdvri 241 7 SR SR NNP cord-349011-kxhpdvri 241 8 - - : cord-349011-kxhpdvri 241 9 As as IN cord-349011-kxhpdvri 241 10 could could MD cord-349011-kxhpdvri 241 11 serve serve VB cord-349011-kxhpdvri 241 12 as as IN cord-349011-kxhpdvri 241 13 surface surface NN cord-349011-kxhpdvri 241 14 receptors receptor NNS cord-349011-kxhpdvri 241 15 for for IN cord-349011-kxhpdvri 241 16 the the DT cord-349011-kxhpdvri 241 17 ranavirus ranavirus NNP cord-349011-kxhpdvri 241 18 , , , cord-349011-kxhpdvri 241 19 frog frog NNP cord-349011-kxhpdvri 241 20 _SP cord-349011-kxhpdvri 242 1 Dr. Dr. NNP cord-349011-kxhpdvri 242 2 Karen Karen NNP cord-349011-kxhpdvri 242 3 Mossman Mossman NNP cord-349011-kxhpdvri 242 4 ( ( -LRB- cord-349011-kxhpdvri 242 5 McMaster McMaster NNP cord-349011-kxhpdvri 242 6 University University NNP cord-349011-kxhpdvri 242 7 ) ) -RRB- cord-349011-kxhpdvri 242 8 chaired chair VBD cord-349011-kxhpdvri 242 9 the the DT cord-349011-kxhpdvri 242 10 final final JJ cord-349011-kxhpdvri 242 11 symposium symposium NN cord-349011-kxhpdvri 242 12 session session NN cord-349011-kxhpdvri 242 13 on on IN cord-349011-kxhpdvri 242 14 " " `` cord-349011-kxhpdvri 242 15 Antiviral Antiviral NNP cord-349011-kxhpdvri 242 16 Innate Innate NNP cord-349011-kxhpdvri 242 17 Immunity Immunity NNP cord-349011-kxhpdvri 242 18 " " '' cord-349011-kxhpdvri 242 19 , , , cord-349011-kxhpdvri 242 20 which which WDT cord-349011-kxhpdvri 242 21 was be VBD cord-349011-kxhpdvri 242 22 led lead VBN cord-349011-kxhpdvri 242 23 off off RP cord-349011-kxhpdvri 242 24 by by IN cord-349011-kxhpdvri 242 25 her -PRON- PRP$ cord-349011-kxhpdvri 242 26 former former JJ cord-349011-kxhpdvri 242 27 post post JJ cord-349011-kxhpdvri 242 28 - - JJ cord-349011-kxhpdvri 242 29 doctoral doctoral JJ cord-349011-kxhpdvri 242 30 fellow fellow NN cord-349011-kxhpdvri 242 31 Dr. Dr. NNP cord-349011-kxhpdvri 242 32 Stephanie Stephanie NNP cord-349011-kxhpdvri 242 33 DeWitte DeWitte NNP cord-349011-kxhpdvri 242 34 - - HYPH cord-349011-kxhpdvri 242 35 Orr Orr NNP cord-349011-kxhpdvri 242 36 ( ( -LRB- cord-349011-kxhpdvri 242 37 Wilfrid Wilfrid NNP cord-349011-kxhpdvri 242 38 Laurier Laurier NNP cord-349011-kxhpdvri 242 39 University University NNP cord-349011-kxhpdvri 242 40 ) ) -RRB- cord-349011-kxhpdvri 242 41 who who WP cord-349011-kxhpdvri 242 42 discussed discuss VBD cord-349011-kxhpdvri 242 43 roles role NNS cord-349011-kxhpdvri 242 44 for for IN cord-349011-kxhpdvri 242 45 class class NN cord-349011-kxhpdvri 242 46 A a DT cord-349011-kxhpdvri 242 47 scavenger scavenger NN cord-349011-kxhpdvri 242 48 receptors receptor NNS cord-349011-kxhpdvri 242 49 ( ( -LRB- cord-349011-kxhpdvri 242 50 SR SR NNP cord-349011-kxhpdvri 242 51 - - : cord-349011-kxhpdvri 242 52 As as IN cord-349011-kxhpdvri 242 53 ) ) -RRB- cord-349011-kxhpdvri 242 54 in in IN cord-349011-kxhpdvri 242 55 innate innate JJ cord-349011-kxhpdvri 242 56 antiviral antiviral JJ cord-349011-kxhpdvri 242 57 immunity immunity NN cord-349011-kxhpdvri 242 58 in in IN cord-349011-kxhpdvri 242 59 lower low JJR cord-349011-kxhpdvri 242 60 vertebrates vertebrate NNS cord-349011-kxhpdvri 242 61 . . . cord-349011-kxhpdvri 243 1 In in IN cord-349011-kxhpdvri 243 2 mammals mammal NNS cord-349011-kxhpdvri 243 3 the the DT cord-349011-kxhpdvri 243 4 SR SR NNP cord-349011-kxhpdvri 243 5 - - : cord-349011-kxhpdvri 243 6 As as IN cord-349011-kxhpdvri 243 7 include include VBP cord-349011-kxhpdvri 243 8 five five CD cord-349011-kxhpdvri 243 9 family family NN cord-349011-kxhpdvri 243 10 members member NNS cord-349011-kxhpdvri 243 11 ( ( -LRB- cord-349011-kxhpdvri 243 12 SR SR NNP cord-349011-kxhpdvri 243 13 - - HYPH cord-349011-kxhpdvri 243 14 AI AI NNP cord-349011-kxhpdvri 243 15 , , , cord-349011-kxhpdvri 243 16 MARCO MARCO NNP cord-349011-kxhpdvri 243 17 , , , cord-349011-kxhpdvri 243 18 SCARA3 SCARA3 NNP cord-349011-kxhpdvri 243 19 , , , cord-349011-kxhpdvri 243 20 SCARA4 scara4 NN cord-349011-kxhpdvri 243 21 and and CC cord-349011-kxhpdvri 243 22 SCARA5 scara5 NN cord-349011-kxhpdvri 243 23 ) ) -RRB- cord-349011-kxhpdvri 243 24 that that WDT cord-349011-kxhpdvri 243 25 play play VBP cord-349011-kxhpdvri 243 26 diverse diverse JJ cord-349011-kxhpdvri 243 27 roles role NNS cord-349011-kxhpdvri 243 28 in in IN cord-349011-kxhpdvri 243 29 immunity immunity NN cord-349011-kxhpdvri 243 30 , , , cord-349011-kxhpdvri 243 31 aiding aid VBG cord-349011-kxhpdvri 243 32 macrophage macrophage NN cord-349011-kxhpdvri 243 33 clearance clearance NN cord-349011-kxhpdvri 243 34 of of IN cord-349011-kxhpdvri 243 35 pathogens pathogen NNS cord-349011-kxhpdvri 243 36 and and CC cord-349011-kxhpdvri 243 37 apoptotic apoptotic JJ cord-349011-kxhpdvri 243 38 cells cell NNS cord-349011-kxhpdvri 243 39 , , , cord-349011-kxhpdvri 243 40 and and CC cord-349011-kxhpdvri 243 41 acting act VBG cord-349011-kxhpdvri 243 42 as as IN cord-349011-kxhpdvri 243 43 receptors receptor NNS cord-349011-kxhpdvri 243 44 for for IN cord-349011-kxhpdvri 243 45 immune immune NN cord-349011-kxhpdvri 243 46 - - HYPH cord-349011-kxhpdvri 243 47 stimulating stimulate VBG cord-349011-kxhpdvri 243 48 molecules molecule NNS cord-349011-kxhpdvri 243 49 . . . cord-349011-kxhpdvri 244 1 They -PRON- PRP cord-349011-kxhpdvri 244 2 have have VBP cord-349011-kxhpdvri 244 3 also also RB cord-349011-kxhpdvri 244 4 been be VBN cord-349011-kxhpdvri 244 5 shown show VBN cord-349011-kxhpdvri 244 6 to to TO cord-349011-kxhpdvri 244 7 serve serve VB cord-349011-kxhpdvri 244 8 as as IN cord-349011-kxhpdvri 244 9 virus virus NN cord-349011-kxhpdvri 244 10 receptors receptor NNS cord-349011-kxhpdvri 244 11 . . . cord-349011-kxhpdvri 245 1 Notwithstanding notwithstanding IN cord-349011-kxhpdvri 245 2 how how WRB cord-349011-kxhpdvri 245 3 important important JJ cord-349011-kxhpdvri 245 4 these these DT cord-349011-kxhpdvri 245 5 receptors receptor NNS cord-349011-kxhpdvri 245 6 are be VBP cord-349011-kxhpdvri 245 7 to to TO cord-349011-kxhpdvri 245 8 host host VB cord-349011-kxhpdvri 245 9 immunity immunity NN cord-349011-kxhpdvri 245 10 , , , cord-349011-kxhpdvri 245 11 little little JJ cord-349011-kxhpdvri 245 12 is be VBZ cord-349011-kxhpdvri 245 13 known know VBN cord-349011-kxhpdvri 245 14 regarding regard VBG cord-349011-kxhpdvri 245 15 SR SR NNP cord-349011-kxhpdvri 245 16 - - HYPH cord-349011-kxhpdvri 245 17 A a DT cord-349011-kxhpdvri 245 18 function function NN cord-349011-kxhpdvri 245 19 in in IN cord-349011-kxhpdvri 245 20 lower low JJR cord-349011-kxhpdvri 245 21 vertebrates vertebrate NNS cord-349011-kxhpdvri 245 22 . . . cord-349011-kxhpdvri 246 1 Dr. Dr. NNP cord-349011-kxhpdvri 246 2 DeWitte DeWitte NNP cord-349011-kxhpdvri 246 3 - - HYPH cord-349011-kxhpdvri 246 4 Orr Orr NNP cord-349011-kxhpdvri 246 5 presented present VBD cord-349011-kxhpdvri 246 6 her -PRON- PRP$ cord-349011-kxhpdvri 246 7 findings finding NNS cord-349011-kxhpdvri 246 8 to to IN cord-349011-kxhpdvri 246 9 date date NN cord-349011-kxhpdvri 246 10 regarding regard VBG cord-349011-kxhpdvri 246 11 SR SR NNP cord-349011-kxhpdvri 246 12 - - : cord-349011-kxhpdvri 246 13 As as IN cord-349011-kxhpdvri 246 14 and and CC cord-349011-kxhpdvri 246 15 their -PRON- PRP$ cord-349011-kxhpdvri 246 16 functions function NNS cord-349011-kxhpdvri 246 17 in in IN cord-349011-kxhpdvri 246 18 fish fish NN cord-349011-kxhpdvri 246 19 and and CC cord-349011-kxhpdvri 246 20 frogs frog NNS cord-349011-kxhpdvri 246 21 . . . cord-349011-kxhpdvri 247 1 Dr. Dr. NNP cord-349011-kxhpdvri 247 2 DeWitte DeWitte NNP cord-349011-kxhpdvri 247 3 - - HYPH cord-349011-kxhpdvri 247 4 Orr Orr NNP cord-349011-kxhpdvri 247 5 has have VBZ cord-349011-kxhpdvri 247 6 identified identify VBN cord-349011-kxhpdvri 247 7 MARCO MARCO NNP cord-349011-kxhpdvri 247 8 , , , cord-349011-kxhpdvri 247 9 SCARA3 SCARA3 NNP cord-349011-kxhpdvri 247 10 , , , cord-349011-kxhpdvri 247 11 SCARA4 scara4 NN cord-349011-kxhpdvri 247 12 and and CC cord-349011-kxhpdvri 247 13 SCARA5 scara5 NN cord-349011-kxhpdvri 247 14 sequences sequence NNS cord-349011-kxhpdvri 247 15 from from IN cord-349011-kxhpdvri 247 16 rainbow rainbow NN cord-349011-kxhpdvri 247 17 trout trout NNP cord-349011-kxhpdvri 247 18 [ [ -LRB- cord-349011-kxhpdvri 247 19 59 59 CD cord-349011-kxhpdvri 247 20 , , , cord-349011-kxhpdvri 247 21 60 60 CD cord-349011-kxhpdvri 247 22 ] ] -RRB- cord-349011-kxhpdvri 247 23 . . . cord-349011-kxhpdvri 248 1 These these DT cord-349011-kxhpdvri 248 2 SR SR NNP cord-349011-kxhpdvri 248 3 - - : cord-349011-kxhpdvri 248 4 As as IN cord-349011-kxhpdvri 248 5 appear appear VBP cord-349011-kxhpdvri 248 6 to to TO cord-349011-kxhpdvri 248 7 be be VB cord-349011-kxhpdvri 248 8 functional functional JJ cord-349011-kxhpdvri 248 9 in in IN cord-349011-kxhpdvri 248 10 rainbow rainbow NN cord-349011-kxhpdvri 248 11 trout trout NNS cord-349011-kxhpdvri 248 12 , , , cord-349011-kxhpdvri 248 13 and and CC cord-349011-kxhpdvri 248 14 act act VB cord-349011-kxhpdvri 248 15 as as IN cord-349011-kxhpdvri 248 16 surface surface NN cord-349011-kxhpdvri 248 17 receptors receptor NNS cord-349011-kxhpdvri 248 18 for for IN cord-349011-kxhpdvri 248 19 double double RB cord-349011-kxhpdvri 248 20 - - HYPH cord-349011-kxhpdvri 248 21 stranded strand VBN cord-349011-kxhpdvri 248 22 RNA RNA NNP cord-349011-kxhpdvri 248 23 ( ( -LRB- cord-349011-kxhpdvri 248 24 dsRNA dsrna NN cord-349011-kxhpdvri 248 25 ) ) -RRB- cord-349011-kxhpdvri 248 26 , , , cord-349011-kxhpdvri 248 27 a a DT cord-349011-kxhpdvri 248 28 virus virus NN cord-349011-kxhpdvri 248 29 - - HYPH cord-349011-kxhpdvri 248 30 derived derive VBN cord-349011-kxhpdvri 248 31 innate innate JJ cord-349011-kxhpdvri 248 32 immune immune JJ cord-349011-kxhpdvri 248 33 stimulant stimulant NN cord-349011-kxhpdvri 248 34 [ [ -LRB- cord-349011-kxhpdvri 248 35 61 61 CD cord-349011-kxhpdvri 248 36 ] ] -RRB- cord-349011-kxhpdvri 248 37 . . . cord-349011-kxhpdvri 249 1 Interestingly interestingly RB cord-349011-kxhpdvri 249 2 , , , cord-349011-kxhpdvri 249 3 MARCO MARCO NNP cord-349011-kxhpdvri 249 4 does do VBZ cord-349011-kxhpdvri 249 5 not not RB cord-349011-kxhpdvri 249 6 appear appear VB cord-349011-kxhpdvri 249 7 to to TO cord-349011-kxhpdvri 249 8 bind bind VB cord-349011-kxhpdvri 249 9 dsRNA dsrna NN cord-349011-kxhpdvri 249 10 , , , cord-349011-kxhpdvri 249 11 a a DT cord-349011-kxhpdvri 249 12 unique unique JJ cord-349011-kxhpdvri 249 13 finding finding NN cord-349011-kxhpdvri 249 14 in in IN cord-349011-kxhpdvri 249 15 vertebrates vertebrate NNS cord-349011-kxhpdvri 249 16 [ [ -LRB- cord-349011-kxhpdvri 249 17 59 59 CD cord-349011-kxhpdvri 249 18 ] ] -RRB- cord-349011-kxhpdvri 249 19 . . . cord-349011-kxhpdvri 250 1 SR- SR- NNP cord-349011-kxhpdvri 251 1 As as IN cord-349011-kxhpdvri 251 2 appear appear VB cord-349011-kxhpdvri 251 3 to to TO cord-349011-kxhpdvri 251 4 be be VB cord-349011-kxhpdvri 251 5 surface surface NN cord-349011-kxhpdvri 251 6 receptors receptor NNS cord-349011-kxhpdvri 251 7 in in IN cord-349011-kxhpdvri 251 8 amphibian amphibian NN cord-349011-kxhpdvri 251 9 cells cell NNS cord-349011-kxhpdvri 251 10 as as RB cord-349011-kxhpdvri 251 11 well well RB cord-349011-kxhpdvri 251 12 , , , cord-349011-kxhpdvri 251 13 as as IN cord-349011-kxhpdvri 251 14 Dr. Dr. NNP cord-349011-kxhpdvri 251 15 DeWitte DeWitte NNP cord-349011-kxhpdvri 251 16 - - HYPH cord-349011-kxhpdvri 251 17 Orr Orr NNP cord-349011-kxhpdvri 251 18 presented present VBD cord-349011-kxhpdvri 251 19 her -PRON- PRP$ cord-349011-kxhpdvri 251 20 findings finding NNS cord-349011-kxhpdvri 251 21 regarding regard VBG cord-349011-kxhpdvri 251 22 SR SR NNP cord-349011-kxhpdvri 251 23 - - HYPH cord-349011-kxhpdvri 251 24 A A NNP cord-349011-kxhpdvri 251 25 mediated mediate VBN cord-349011-kxhpdvri 251 26 dsRNA dsrna NN cord-349011-kxhpdvri 251 27 responses response NNS cord-349011-kxhpdvri 251 28 in in IN cord-349011-kxhpdvri 251 29 the the DT cord-349011-kxhpdvri 251 30 American american JJ cord-349011-kxhpdvri 251 31 toad toad NN cord-349011-kxhpdvri 251 32 cell cell NN cord-349011-kxhpdvri 251 33 line line NN cord-349011-kxhpdvri 251 34 , , , cord-349011-kxhpdvri 251 35 BufoTad BufoTad NNP cord-349011-kxhpdvri 251 36 [ [ -LRB- cord-349011-kxhpdvri 251 37 62 62 CD cord-349011-kxhpdvri 251 38 ] ] -RRB- cord-349011-kxhpdvri 251 39 . . . cord-349011-kxhpdvri 252 1 In in IN cord-349011-kxhpdvri 252 2 addition addition NN cord-349011-kxhpdvri 252 3 to to TO cord-349011-kxhpdvri 252 4 function function VB cord-349011-kxhpdvri 252 5 studies study NNS cord-349011-kxhpdvri 252 6 , , , cord-349011-kxhpdvri 252 7 the the DT cord-349011-kxhpdvri 252 8 DeWitte DeWitte NNP cord-349011-kxhpdvri 252 9 - - HYPH cord-349011-kxhpdvri 252 10 Orr Orr NNP cord-349011-kxhpdvri 252 11 group group NN cord-349011-kxhpdvri 252 12 has have VBZ cord-349011-kxhpdvri 252 13 identified identify VBN cord-349011-kxhpdvri 252 14 a a DT cord-349011-kxhpdvri 252 15 cell cell NN cord-349011-kxhpdvri 252 16 line line NN cord-349011-kxhpdvri 252 17 derived derive VBN cord-349011-kxhpdvri 252 18 from from IN cord-349011-kxhpdvri 252 19 Chinook Chinook NNP cord-349011-kxhpdvri 252 20 salmon salmon NN cord-349011-kxhpdvri 252 21 ( ( -LRB- cord-349011-kxhpdvri 252 22 CHSE-214 CHSE-214 NNP cord-349011-kxhpdvri 252 23 ) ) -RRB- cord-349011-kxhpdvri 252 24 that that WDT cord-349011-kxhpdvri 252 25 appears appear VBZ cord-349011-kxhpdvri 252 26 to to TO cord-349011-kxhpdvri 252 27 lack lack VB cord-349011-kxhpdvri 252 28 functional functional JJ cord-349011-kxhpdvri 252 29 SR SR NNP cord-349011-kxhpdvri 252 30 - - : cord-349011-kxhpdvri 252 31 As As NNP cord-349011-kxhpdvri 252 32 and and CC cord-349011-kxhpdvri 252 33 can can MD cord-349011-kxhpdvri 252 34 be be VB cord-349011-kxhpdvri 252 35 used use VBN cord-349011-kxhpdvri 252 36 as as IN cord-349011-kxhpdvri 252 37 a a DT cord-349011-kxhpdvri 252 38 model model NN cord-349011-kxhpdvri 252 39 for for IN cord-349011-kxhpdvri 252 40 SR SR NNP cord-349011-kxhpdvri 252 41 - - HYPH cord-349011-kxhpdvri 252 42 A A NNP cord-349011-kxhpdvri 252 43 / / SYM cord-349011-kxhpdvri 252 44 dsRNA dsrna NN cord-349011-kxhpdvri 252 45 binding bind VBG cord-349011-kxhpdvri 252 46 [ [ -LRB- cord-349011-kxhpdvri 252 47 63 63 CD cord-349011-kxhpdvri 252 48 ] ] -RRB- cord-349011-kxhpdvri 252 49 . . . cord-349011-kxhpdvri 253 1 Finally finally RB cord-349011-kxhpdvri 253 2 , , , cord-349011-kxhpdvri 253 3 she -PRON- PRP cord-349011-kxhpdvri 253 4 presented present VBD cord-349011-kxhpdvri 253 5 evidence evidence NN cord-349011-kxhpdvri 253 6 that that IN cord-349011-kxhpdvri 253 7 SR SR NNP cord-349011-kxhpdvri 253 8 - - : cord-349011-kxhpdvri 253 9 As as IN cord-349011-kxhpdvri 253 10 could could MD cord-349011-kxhpdvri 253 11 serve serve VB cord-349011-kxhpdvri 253 12 as as IN cord-349011-kxhpdvri 253 13 surface surface NN cord-349011-kxhpdvri 253 14 receptors receptor NNS cord-349011-kxhpdvri 253 15 for for IN cord-349011-kxhpdvri 253 16 the the DT cord-349011-kxhpdvri 253 17 ranavirus ranavirus NNP cord-349011-kxhpdvri 253 18 , , , cord-349011-kxhpdvri 253 19 frog frog NNP cord-349011-kxhpdvri 253 20 virus-3 virus-3 NNP cord-349011-kxhpdvri 254 1 ( ( -LRB- cord-349011-kxhpdvri 254 2 work work NN cord-349011-kxhpdvri 254 3 described describe VBN cord-349011-kxhpdvri 254 4 in in IN cord-349011-kxhpdvri 254 5 this this DT cord-349011-kxhpdvri 254 6 Special Special NNP cord-349011-kxhpdvri 254 7 Issue Issue NNP cord-349011-kxhpdvri 254 8 ) ) -RRB- cord-349011-kxhpdvri 254 9 . . . cord-349011-kxhpdvri 255 1 Together together RB cord-349011-kxhpdvri 255 2 , , , cord-349011-kxhpdvri 255 3 these these DT cord-349011-kxhpdvri 255 4 findings finding NNS cord-349011-kxhpdvri 255 5 provide provide VBP cord-349011-kxhpdvri 255 6 the the DT cord-349011-kxhpdvri 255 7 first first JJ cord-349011-kxhpdvri 255 8 glimpse glimpse NN cord-349011-kxhpdvri 255 9 into into IN cord-349011-kxhpdvri 255 10 the the DT cord-349011-kxhpdvri 255 11 role role NN cord-349011-kxhpdvri 255 12 of of IN cord-349011-kxhpdvri 255 13 SR SR NNP cord-349011-kxhpdvri 255 14 - - : cord-349011-kxhpdvri 255 15 As as IN cord-349011-kxhpdvri 255 16 in in IN cord-349011-kxhpdvri 255 17 innate innate JJ cord-349011-kxhpdvri 255 18 antiviral antiviral JJ cord-349011-kxhpdvri 255 19 immunity immunity NN cord-349011-kxhpdvri 255 20 in in IN cord-349011-kxhpdvri 255 21 lower low JJR cord-349011-kxhpdvri 255 22 vertebrates vertebrate NNS cord-349011-kxhpdvri 255 23 . . . cord-349011-kxhpdvri 256 1 Continuing continue VBG cord-349011-kxhpdvri 256 2 with with IN cord-349011-kxhpdvri 256 3 the the DT cord-349011-kxhpdvri 256 4 theme theme NN cord-349011-kxhpdvri 256 5 on on IN cord-349011-kxhpdvri 256 6 innate innate JJ cord-349011-kxhpdvri 256 7 immunity immunity NN cord-349011-kxhpdvri 256 8 in in IN cord-349011-kxhpdvri 256 9 non non JJ cord-349011-kxhpdvri 256 10 - - JJ cord-349011-kxhpdvri 256 11 human human JJ cord-349011-kxhpdvri 256 12 hosts host NNS cord-349011-kxhpdvri 256 13 , , , cord-349011-kxhpdvri 256 14 Dr. Dr. NNP cord-349011-kxhpdvri 256 15 Katharine Katharine NNP cord-349011-kxhpdvri 256 16 Magor Magor NNP cord-349011-kxhpdvri 256 17 ( ( -LRB- cord-349011-kxhpdvri 256 18 University University NNP cord-349011-kxhpdvri 256 19 of of IN cord-349011-kxhpdvri 256 20 Alberta Alberta NNP cord-349011-kxhpdvri 256 21 ) ) -RRB- cord-349011-kxhpdvri 256 22 presented present VBD cord-349011-kxhpdvri 256 23 her -PRON- PRP$ cord-349011-kxhpdvri 256 24 studies study NNS cord-349011-kxhpdvri 256 25 of of IN cord-349011-kxhpdvri 256 26 non non JJ cord-349011-kxhpdvri 256 27 - - JJ cord-349011-kxhpdvri 256 28 pathogenic pathogenic JJ cord-349011-kxhpdvri 256 29 and and CC cord-349011-kxhpdvri 256 30 pathogenic pathogenic JJ cord-349011-kxhpdvri 256 31 influenza influenza NN cord-349011-kxhpdvri 256 32 A a DT cord-349011-kxhpdvri 256 33 virus virus NN cord-349011-kxhpdvri 256 34 ( ( -LRB- cord-349011-kxhpdvri 256 35 IAV iav NN cord-349011-kxhpdvri 256 36 ) ) -RRB- cord-349011-kxhpdvri 256 37 infection infection NN cord-349011-kxhpdvri 256 38 of of IN cord-349011-kxhpdvri 256 39 ducks duck NNS cord-349011-kxhpdvri 256 40 . . . cord-349011-kxhpdvri 257 1 Dr. Dr. NNP cord-349011-kxhpdvri 257 2 Magor Magor NNP cord-349011-kxhpdvri 257 3 shared share VBD cord-349011-kxhpdvri 257 4 a a DT cord-349011-kxhpdvri 257 5 photo photo NN cord-349011-kxhpdvri 257 6 of of IN cord-349011-kxhpdvri 257 7 herself -PRON- PRP cord-349011-kxhpdvri 257 8 as as IN cord-349011-kxhpdvri 257 9 a a DT cord-349011-kxhpdvri 257 10 child child NN cord-349011-kxhpdvri 257 11 cradling cradle VBG cord-349011-kxhpdvri 257 12 her -PRON- PRP$ cord-349011-kxhpdvri 257 13 pet pet JJ cord-349011-kxhpdvri 257 14 duck duck NN cord-349011-kxhpdvri 257 15 in in IN cord-349011-kxhpdvri 257 16 Yarmouth Yarmouth NNP cord-349011-kxhpdvri 257 17 , , , cord-349011-kxhpdvri 257 18 Nova Nova NNP cord-349011-kxhpdvri 257 19 Scotia Scotia NNP cord-349011-kxhpdvri 257 20 , , , cord-349011-kxhpdvri 257 21 and and CC cord-349011-kxhpdvri 257 22 explained explain VBD cord-349011-kxhpdvri 257 23 how how WRB cord-349011-kxhpdvri 257 24 this this DT cord-349011-kxhpdvri 257 25 early early JJ cord-349011-kxhpdvri 257 26 love love NN cord-349011-kxhpdvri 257 27 of of IN cord-349011-kxhpdvri 257 28 animals animal NNS cord-349011-kxhpdvri 257 29 influenced influence VBD cord-349011-kxhpdvri 257 30 her -PRON- PRP$ cord-349011-kxhpdvri 257 31 career career NN cord-349011-kxhpdvri 257 32 path path NN cord-349011-kxhpdvri 257 33 . . . cord-349011-kxhpdvri 258 1 Ducks duck NNS cord-349011-kxhpdvri 258 2 are be VBP cord-349011-kxhpdvri 258 3 the the DT cord-349011-kxhpdvri 258 4 natural natural JJ cord-349011-kxhpdvri 258 5 IAV IAV NNP cord-349011-kxhpdvri 258 6 reservoir reservoir NN cord-349011-kxhpdvri 258 7 host host NN cord-349011-kxhpdvri 258 8 ; ; : cord-349011-kxhpdvri 258 9 the the DT cord-349011-kxhpdvri 258 10 virus virus NN cord-349011-kxhpdvri 258 11 infects infect VBZ cord-349011-kxhpdvri 258 12 the the DT cord-349011-kxhpdvri 258 13 gastrointestinal gastrointestinal JJ cord-349011-kxhpdvri 258 14 tract tract NN cord-349011-kxhpdvri 258 15 and and CC cord-349011-kxhpdvri 258 16 typically typically RB cord-349011-kxhpdvri 258 17 does do VBZ cord-349011-kxhpdvri 258 18 not not RB cord-349011-kxhpdvri 258 19 cause cause VB cord-349011-kxhpdvri 258 20 overt overt JJ cord-349011-kxhpdvri 258 21 disease disease NN cord-349011-kxhpdvri 258 22 . . . cord-349011-kxhpdvri 259 1 However however RB cord-349011-kxhpdvri 259 2 , , , cord-349011-kxhpdvri 259 3 the the DT cord-349011-kxhpdvri 259 4 emergence emergence NN cord-349011-kxhpdvri 259 5 of of IN cord-349011-kxhpdvri 259 6 avian avian JJ cord-349011-kxhpdvri 259 7 H5N1 H5N1 NNP cord-349011-kxhpdvri 259 8 IAV IAV NNP cord-349011-kxhpdvri 259 9 strains strain NNS cord-349011-kxhpdvri 259 10 with with IN cord-349011-kxhpdvri 259 11 pandemic pandemic NN cord-349011-kxhpdvri 259 12 potential potential JJ cord-349011-kxhpdvri 259 13 have have VBP cord-349011-kxhpdvri 259 14 disrupted disrupt VBN cord-349011-kxhpdvri 259 15 this this DT cord-349011-kxhpdvri 259 16 balance balance NN cord-349011-kxhpdvri 259 17 and and CC cord-349011-kxhpdvri 259 18 can can MD cord-349011-kxhpdvri 259 19 cause cause VB cord-349011-kxhpdvri 259 20 lethal lethal JJ cord-349011-kxhpdvri 259 21 infection infection NN cord-349011-kxhpdvri 259 22 in in IN cord-349011-kxhpdvri 259 23 ducks duck NNS cord-349011-kxhpdvri 259 24 . . . cord-349011-kxhpdvri 260 1 To to TO cord-349011-kxhpdvri 260 2 better well RBR cord-349011-kxhpdvri 260 3 understand understand VB cord-349011-kxhpdvri 260 4 the the DT cord-349011-kxhpdvri 260 5 pathogenic pathogenic JJ cord-349011-kxhpdvri 260 6 effects effect NNS cord-349011-kxhpdvri 260 7 of of IN cord-349011-kxhpdvri 260 8 lethal lethal JJ cord-349011-kxhpdvri 260 9 H5N1 H5N1 NNP cord-349011-kxhpdvri 260 10 infection infection NN cord-349011-kxhpdvri 260 11 in in IN cord-349011-kxhpdvri 260 12 ducks duck NNS cord-349011-kxhpdvri 260 13 , , , cord-349011-kxhpdvri 260 14 Dr. Dr. NNP cord-349011-kxhpdvri 260 15 Magor Magor NNP cord-349011-kxhpdvri 260 16 established establish VBD cord-349011-kxhpdvri 260 17 an an DT cord-349011-kxhpdvri 260 18 infection infection NN cord-349011-kxhpdvri 260 19 model model NN cord-349011-kxhpdvri 260 20 of of IN cord-349011-kxhpdvri 260 21 White White NNP cord-349011-kxhpdvri 260 22 Pekin Pekin NNP cord-349011-kxhpdvri 260 23 ducks duck NNS cord-349011-kxhpdvri 260 24 with with IN cord-349011-kxhpdvri 260 25 three three CD cord-349011-kxhpdvri 260 26 similar similar JJ cord-349011-kxhpdvri 260 27 H5N1 H5N1 NNP cord-349011-kxhpdvri 260 28 viruses virus NNS cord-349011-kxhpdvri 260 29 with with IN cord-349011-kxhpdvri 260 30 known know VBN cord-349011-kxhpdvri 260 31 differences difference NNS cord-349011-kxhpdvri 260 32 in in IN cord-349011-kxhpdvri 260 33 pathogenicity pathogenicity NN cord-349011-kxhpdvri 260 34 and and CC cord-349011-kxhpdvri 260 35 replication replication NN cord-349011-kxhpdvri 260 36 rate rate NN cord-349011-kxhpdvri 260 37 [ [ -LRB- cord-349011-kxhpdvri 260 38 64 64 CD cord-349011-kxhpdvri 260 39 ] ] -RRB- cord-349011-kxhpdvri 260 40 . . . cord-349011-kxhpdvri 261 1 Viral viral JJ cord-349011-kxhpdvri 261 2 replication replication NN cord-349011-kxhpdvri 261 3 and and CC cord-349011-kxhpdvri 261 4 host host NN cord-349011-kxhpdvri 261 5 responses response NNS cord-349011-kxhpdvri 261 6 were be VBD cord-349011-kxhpdvri 261 7 measured measure VBN cord-349011-kxhpdvri 261 8 by by IN cord-349011-kxhpdvri 261 9 RT RT NNP cord-349011-kxhpdvri 261 10 - - HYPH cord-349011-kxhpdvri 261 11 qPCR qPCR NNP cord-349011-kxhpdvri 261 12 at at IN cord-349011-kxhpdvri 261 13 different different JJ cord-349011-kxhpdvri 261 14 times time NNS cord-349011-kxhpdvri 261 15 post post JJ cord-349011-kxhpdvri 261 16 - - NN cord-349011-kxhpdvri 261 17 infection infection NN cord-349011-kxhpdvri 261 18 . . . cord-349011-kxhpdvri 262 1 Viral viral JJ cord-349011-kxhpdvri 262 2 replication replication NN cord-349011-kxhpdvri 262 3 peaked peak VBD cord-349011-kxhpdvri 262 4 and and CC cord-349011-kxhpdvri 262 5 viral viral JJ cord-349011-kxhpdvri 262 6 load load NN cord-349011-kxhpdvri 262 7 declined decline VBD cord-349011-kxhpdvri 262 8 in in IN cord-349011-kxhpdvri 262 9 the the DT cord-349011-kxhpdvri 262 10 spleen spleen NN cord-349011-kxhpdvri 262 11 over over IN cord-349011-kxhpdvri 262 12 time time NN cord-349011-kxhpdvri 262 13 . . . cord-349011-kxhpdvri 263 1 The the DT cord-349011-kxhpdvri 263 2 ducks duck NNS cord-349011-kxhpdvri 263 3 rapidly rapidly RB cord-349011-kxhpdvri 263 4 mounted mount VBD cord-349011-kxhpdvri 263 5 interferon interferon NN cord-349011-kxhpdvri 263 6 and and CC cord-349011-kxhpdvri 263 7 cytokine cytokine NN cord-349011-kxhpdvri 263 8 responses response NNS cord-349011-kxhpdvri 263 9 that that WDT cord-349011-kxhpdvri 263 10 peaked peak VBD cord-349011-kxhpdvri 263 11 on on IN cord-349011-kxhpdvri 263 12 the the DT cord-349011-kxhpdvri 263 13 first first JJ cord-349011-kxhpdvri 263 14 day day NN cord-349011-kxhpdvri 263 15 of of IN cord-349011-kxhpdvri 263 16 infection infection NN cord-349011-kxhpdvri 263 17 and and CC cord-349011-kxhpdvri 263 18 declined decline VBD cord-349011-kxhpdvri 263 19 thereafter thereafter RB cord-349011-kxhpdvri 263 20 , , , cord-349011-kxhpdvri 263 21 with with IN cord-349011-kxhpdvri 263 22 the the DT cord-349011-kxhpdvri 263 23 strongest strong JJS cord-349011-kxhpdvri 263 24 responses response NNS cord-349011-kxhpdvri 263 25 coming come VBG cord-349011-kxhpdvri 263 26 from from IN cord-349011-kxhpdvri 263 27 the the DT cord-349011-kxhpdvri 263 28 high high RB cord-349011-kxhpdvri 263 29 - - HYPH cord-349011-kxhpdvri 263 30 pathogenic pathogenic JJ cord-349011-kxhpdvri 263 31 viruses virus NNS cord-349011-kxhpdvri 263 32 . . . cord-349011-kxhpdvri 264 1 Further further JJ cord-349011-kxhpdvri 264 2 characterization characterization NN cord-349011-kxhpdvri 264 3 of of IN cord-349011-kxhpdvri 264 4 the the DT cord-349011-kxhpdvri 264 5 duck duck NN cord-349011-kxhpdvri 264 6 immune immune JJ cord-349011-kxhpdvri 264 7 responses response NNS cord-349011-kxhpdvri 264 8 to to IN cord-349011-kxhpdvri 264 9 lethal lethal JJ cord-349011-kxhpdvri 264 10 and and CC cord-349011-kxhpdvri 264 11 sub sub JJ cord-349011-kxhpdvri 264 12 - - JJ cord-349011-kxhpdvri 264 13 lethal lethal JJ cord-349011-kxhpdvri 264 14 infections infection NNS cord-349011-kxhpdvri 264 15 could could MD cord-349011-kxhpdvri 264 16 advance advance VB cord-349011-kxhpdvri 264 17 our -PRON- PRP$ cord-349011-kxhpdvri 264 18 understanding understanding NN cord-349011-kxhpdvri 264 19 of of IN cord-349011-kxhpdvri 264 20 virus virus NN cord-349011-kxhpdvri 264 21 - - HYPH cord-349011-kxhpdvri 264 22 host host NN cord-349011-kxhpdvri 264 23 interactions interaction NNS cord-349011-kxhpdvri 264 24 in in IN cord-349011-kxhpdvri 264 25 the the DT cord-349011-kxhpdvri 264 26 reservoir reservoir NN cord-349011-kxhpdvri 264 27 host host NN cord-349011-kxhpdvri 264 28 . . . cord-349011-kxhpdvri 265 1 The the DT cord-349011-kxhpdvri 265 2 " " `` cord-349011-kxhpdvri 265 3 Antiviral Antiviral NNP cord-349011-kxhpdvri 265 4 Innate Innate NNP cord-349011-kxhpdvri 265 5 Immunity immunity NN cord-349011-kxhpdvri 265 6 " " '' cord-349011-kxhpdvri 265 7 session session NN cord-349011-kxhpdvri 265 8 also also RB cord-349011-kxhpdvri 265 9 included include VBD cord-349011-kxhpdvri 265 10 presentations presentation NNS cord-349011-kxhpdvri 265 11 from from IN cord-349011-kxhpdvri 265 12 the the DT cord-349011-kxhpdvri 265 13 following follow VBG cord-349011-kxhpdvri 265 14 trainees trainee NNS cord-349011-kxhpdvri 265 15 : : : cord-349011-kxhpdvri 266 1 Jiangyi Jiangyi NNP cord-349011-kxhpdvri 266 2 He -PRON- PRP cord-349011-kxhpdvri 266 3 ( ( -LRB- cord-349011-kxhpdvri 266 4 Memorial Memorial NNP cord-349011-kxhpdvri 266 5 University University NNP cord-349011-kxhpdvri 266 6 ) ) -RRB- cord-349011-kxhpdvri 266 7 who who WP cord-349011-kxhpdvri 266 8 described describe VBD cord-349011-kxhpdvri 266 9 mechanisms mechanism NNS cord-349011-kxhpdvri 266 10 of of IN cord-349011-kxhpdvri 266 11 murine murine JJ cord-349011-kxhpdvri 266 12 cytomegalovirus cytomegalovirus JJ cord-349011-kxhpdvri 266 13 immune immune JJ cord-349011-kxhpdvri 266 14 evasion evasion NN cord-349011-kxhpdvri 266 15 , , , cord-349011-kxhpdvri 266 16 Dacquin Dacquin NNP cord-349011-kxhpdvri 266 17 Kasumba Kasumba NNP cord-349011-kxhpdvri 266 18 ( ( -LRB- cord-349011-kxhpdvri 266 19 Université Université NNP cord-349011-kxhpdvri 266 20 de de FW cord-349011-kxhpdvri 266 21 Montréal Montréal NNP cord-349011-kxhpdvri 266 22 ) ) -RRB- cord-349011-kxhpdvri 266 23 who who WP cord-349011-kxhpdvri 266 24 described describe VBD cord-349011-kxhpdvri 266 25 roles role NNS cord-349011-kxhpdvri 266 26 for for IN cord-349011-kxhpdvri 266 27 DUOX2 duox2 NN cord-349011-kxhpdvri 266 28 enzymes enzyme NNS cord-349011-kxhpdvri 266 29 in in IN cord-349011-kxhpdvri 266 30 host host NN cord-349011-kxhpdvri 266 31 responses response NNS cord-349011-kxhpdvri 266 32 to to IN cord-349011-kxhpdvri 266 33 respiratory respiratory JJ cord-349011-kxhpdvri 266 34 virus virus NN cord-349011-kxhpdvri 266 35 infections infection NNS cord-349011-kxhpdvri 266 36 , , , cord-349011-kxhpdvri 266 37 and and CC cord-349011-kxhpdvri 266 38 Hannah Hannah NNP cord-349011-kxhpdvri 266 39 Stacey Stacey NNP cord-349011-kxhpdvri 266 40 ( ( -LRB- cord-349011-kxhpdvri 266 41 McMaster McMaster NNP cord-349011-kxhpdvri 266 42 University University NNP cord-349011-kxhpdvri 266 43 ) ) -RRB- cord-349011-kxhpdvri 266 44 who who WP cord-349011-kxhpdvri 266 45 presented present VBD cord-349011-kxhpdvri 266 46 her -PRON- PRP$ cord-349011-kxhpdvri 266 47 work work NN cord-349011-kxhpdvri 266 48 on on IN cord-349011-kxhpdvri 266 49 IgA IgA NNP cord-349011-kxhpdvri 266 50 immune immune JJ cord-349011-kxhpdvri 266 51 complexes complex NNS cord-349011-kxhpdvri 266 52 in in IN cord-349011-kxhpdvri 266 53 infection infection NN cord-349011-kxhpdvri 266 54 and and CC cord-349011-kxhpdvri 266 55 autoimmunity autoimmunity NN cord-349011-kxhpdvri 266 56 . . . cord-349011-kxhpdvri 267 1 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 267 2 closed close VBD cord-349011-kxhpdvri 267 3 with with IN cord-349011-kxhpdvri 267 4 comments comment NNS cord-349011-kxhpdvri 267 5 from from IN cord-349011-kxhpdvri 267 6 Dr. Dr. NNP cord-349011-kxhpdvri 267 7 Grandvaux Grandvaux NNP cord-349011-kxhpdvri 267 8 thanking thank VBG cord-349011-kxhpdvri 267 9 sponsors sponsor NNS cord-349011-kxhpdvri 267 10 , , , cord-349011-kxhpdvri 267 11 the the DT cord-349011-kxhpdvri 267 12 scientific scientific JJ cord-349011-kxhpdvri 267 13 advisory advisory JJ cord-349011-kxhpdvri 267 14 committee committee NN cord-349011-kxhpdvri 267 15 , , , cord-349011-kxhpdvri 267 16 and and CC cord-349011-kxhpdvri 267 17 the the DT cord-349011-kxhpdvri 267 18 local local JJ cord-349011-kxhpdvri 267 19 organizing organizing NN cord-349011-kxhpdvri 267 20 committee committee NN cord-349011-kxhpdvri 267 21 . . . cord-349011-kxhpdvri 268 1 Following follow VBG cord-349011-kxhpdvri 268 2 an an DT cord-349011-kxhpdvri 268 3 ovation ovation NN cord-349011-kxhpdvri 268 4 for for IN cord-349011-kxhpdvri 268 5 the the DT cord-349011-kxhpdvri 268 6 small small JJ cord-349011-kxhpdvri 268 7 army army NN cord-349011-kxhpdvri 268 8 of of IN cord-349011-kxhpdvri 268 9 local local JJ cord-349011-kxhpdvri 268 10 volunteers volunteer NNS cord-349011-kxhpdvri 268 11 who who WP cord-349011-kxhpdvri 268 12 were be VBD cord-349011-kxhpdvri 268 13 instrumental instrumental JJ cord-349011-kxhpdvri 268 14 to to IN cord-349011-kxhpdvri 268 15 the the DT cord-349011-kxhpdvri 268 16 success success NN cord-349011-kxhpdvri 268 17 of of IN cord-349011-kxhpdvri 268 18 the the DT cord-349011-kxhpdvri 268 19 symposium symposium NN cord-349011-kxhpdvri 268 20 , , , cord-349011-kxhpdvri 268 21 Dr. Dr. NNP cord-349011-kxhpdvri 268 22 Grandvaux Grandvaux NNP cord-349011-kxhpdvri 268 23 announced announce VBD cord-349011-kxhpdvri 268 24 the the DT cord-349011-kxhpdvri 268 25 travel travel NN cord-349011-kxhpdvri 268 26 awards award NNS cord-349011-kxhpdvri 268 27 ( ( -LRB- cord-349011-kxhpdvri 268 28 Figure figure NN cord-349011-kxhpdvri 268 29 5 5 CD cord-349011-kxhpdvri 268 30 ) ) -RRB- cord-349011-kxhpdvri 268 31 . . . cord-349011-kxhpdvri 269 1 We -PRON- PRP cord-349011-kxhpdvri 269 2 then then RB cord-349011-kxhpdvri 269 3 gathered gather VBD cord-349011-kxhpdvri 269 4 outside outside IN cord-349011-kxhpdvri 269 5 the the DT cord-349011-kxhpdvri 269 6 lecture lecture NN cord-349011-kxhpdvri 269 7 theatre theatre NN cord-349011-kxhpdvri 269 8 where where WRB cord-349011-kxhpdvri 269 9 we -PRON- PRP cord-349011-kxhpdvri 269 10 were be VBD cord-349011-kxhpdvri 269 11 met meet VBN cord-349011-kxhpdvri 269 12 by by IN cord-349011-kxhpdvri 269 13 two two CD cord-349011-kxhpdvri 269 14 members member NNS cord-349011-kxhpdvri 269 15 of of IN cord-349011-kxhpdvri 269 16 the the DT cord-349011-kxhpdvri 269 17 78th 78th JJ cord-349011-kxhpdvri 269 18 Highlanders Highlanders NNPS cord-349011-kxhpdvri 269 19 Pipe Pipe NNP cord-349011-kxhpdvri 269 20 Band Band NNP cord-349011-kxhpdvri 269 21 , , , cord-349011-kxhpdvri 269 22 who who WP cord-349011-kxhpdvri 269 23 marched march VBD cord-349011-kxhpdvri 269 24 us -PRON- PRP cord-349011-kxhpdvri 269 25 through through IN cord-349011-kxhpdvri 269 26 the the DT cord-349011-kxhpdvri 269 27 streets street NNS cord-349011-kxhpdvri 269 28 of of IN cord-349011-kxhpdvri 269 29 Halifax Halifax NNP cord-349011-kxhpdvri 269 30 and and CC cord-349011-kxhpdvri 269 31 ascended ascend VBD cord-349011-kxhpdvri 269 32 the the DT cord-349011-kxhpdvri 269 33 slopes slope NNS cord-349011-kxhpdvri 269 34 of of IN cord-349011-kxhpdvri 269 35 the the DT cord-349011-kxhpdvri 269 36 Halifax Halifax NNP cord-349011-kxhpdvri 269 37 Citadel Citadel NNP cord-349011-kxhpdvri 269 38 National National NNP cord-349011-kxhpdvri 269 39 Historic Historic NNP cord-349011-kxhpdvri 269 40 Site Site NNP cord-349011-kxhpdvri 269 41 ( ( -LRB- cord-349011-kxhpdvri 269 42 Figure figure NN cord-349011-kxhpdvri 269 43 6 6 CD cord-349011-kxhpdvri 269 44 ) ) -RRB- cord-349011-kxhpdvri 269 45 . . . cord-349011-kxhpdvri 270 1 Inside inside IN cord-349011-kxhpdvri 270 2 the the DT cord-349011-kxhpdvri 270 3 walls wall NNS cord-349011-kxhpdvri 270 4 of of IN cord-349011-kxhpdvri 270 5 the the DT cord-349011-kxhpdvri 270 6 star star NN cord-349011-kxhpdvri 270 7 - - HYPH cord-349011-kxhpdvri 270 8 shaped shape VBN cord-349011-kxhpdvri 270 9 fortress fortress NN cord-349011-kxhpdvri 270 10 , , , cord-349011-kxhpdvri 270 11 Highlanders Highlanders NNPS cord-349011-kxhpdvri 270 12 conducted conduct VBD cord-349011-kxhpdvri 270 13 historic historic JJ cord-349011-kxhpdvri 270 14 tours tour NNS cord-349011-kxhpdvri 270 15 in in IN cord-349011-kxhpdvri 270 16 English English NNP cord-349011-kxhpdvri 270 17 and and CC cord-349011-kxhpdvri 270 18 French French NNP cord-349011-kxhpdvri 270 19 . . . cord-349011-kxhpdvri 271 1 Then then RB cord-349011-kxhpdvri 271 2 Pipe Pipe NNP cord-349011-kxhpdvri 271 3 and and CC cord-349011-kxhpdvri 271 4 Drum Drum NNP cord-349011-kxhpdvri 271 5 sounded sound VBD cord-349011-kxhpdvri 271 6 once once RB cord-349011-kxhpdvri 271 7 again again RB cord-349011-kxhpdvri 271 8 , , , cord-349011-kxhpdvri 271 9 and and CC cord-349011-kxhpdvri 271 10 we -PRON- PRP cord-349011-kxhpdvri 271 11 marched march VBD cord-349011-kxhpdvri 271 12 out out IN cord-349011-kxhpdvri 271 13 of of IN cord-349011-kxhpdvri 271 14 the the DT cord-349011-kxhpdvri 271 15 Citadel Citadel NNP cord-349011-kxhpdvri 271 16 and and CC cord-349011-kxhpdvri 271 17 down down IN cord-349011-kxhpdvri 271 18 Sackville Sackville NNP cord-349011-kxhpdvri 271 19 Street Street NNP cord-349011-kxhpdvri 271 20 to to IN cord-349011-kxhpdvri 271 21 the the DT cord-349011-kxhpdvri 271 22 historic historic JJ cord-349011-kxhpdvri 271 23 Alexander Alexander NNP cord-349011-kxhpdvri 271 24 Keith Keith NNP cord-349011-kxhpdvri 271 25 's 's POS cord-349011-kxhpdvri 271 26 Brewery Brewery NNP cord-349011-kxhpdvri 271 27 for for IN cord-349011-kxhpdvri 271 28 an an DT cord-349011-kxhpdvri 271 29 evening evening NN cord-349011-kxhpdvri 271 30 featuring feature VBG cord-349011-kxhpdvri 271 31 local local JJ cord-349011-kxhpdvri 271 32 food food NN cord-349011-kxhpdvri 271 33 , , , cord-349011-kxhpdvri 271 34 drink drink NN cord-349011-kxhpdvri 271 35 , , , cord-349011-kxhpdvri 271 36 and and CC cord-349011-kxhpdvri 271 37 music music NN cord-349011-kxhpdvri 271 38 . . . cord-349011-kxhpdvri 272 1 A a DT cord-349011-kxhpdvri 272 2 good good JJ cord-349011-kxhpdvri 272 3 time time NN cord-349011-kxhpdvri 272 4 was be VBD cord-349011-kxhpdvri 272 5 had have VBN cord-349011-kxhpdvri 272 6 by by IN cord-349011-kxhpdvri 272 7 all all DT cord-349011-kxhpdvri 272 8 , , , cord-349011-kxhpdvri 272 9 including include VBG cord-349011-kxhpdvri 272 10 Drs Drs NNP cord-349011-kxhpdvri 272 11 . . . cord-349011-kxhpdvri 273 1 Grandvaux Grandvaux NNP cord-349011-kxhpdvri 273 2 and and CC cord-349011-kxhpdvri 273 3 McCormick McCormick NNP cord-349011-kxhpdvri 273 4 , , , cord-349011-kxhpdvri 273 5 who who WP cord-349011-kxhpdvri 273 6 could could MD cord-349011-kxhpdvri 273 7 be be VB cord-349011-kxhpdvri 273 8 found find VBN cord-349011-kxhpdvri 273 9 relaxing relax VBG cord-349011-kxhpdvri 273 10 in in IN cord-349011-kxhpdvri 273 11 Mr. Mr. NNP cord-349011-kxhpdvri 273 12 Keith Keith NNP cord-349011-kxhpdvri 273 13 's 's POS cord-349011-kxhpdvri 273 14 leather leather NN cord-349011-kxhpdvri 273 15 - - HYPH cord-349011-kxhpdvri 273 16 bound bind VBN cord-349011-kxhpdvri 273 17 office office NN cord-349011-kxhpdvri 273 18 following follow VBG cord-349011-kxhpdvri 273 19 a a DT cord-349011-kxhpdvri 273 20 very very RB cord-349011-kxhpdvri 273 21 successful successful JJ cord-349011-kxhpdvri 273 22 symposium symposium NN cord-349011-kxhpdvri 273 23 ( ( -LRB- cord-349011-kxhpdvri 273 24 Figure Figure NNP cord-349011-kxhpdvri 273 25 7 7 CD cord-349011-kxhpdvri 273 26 ) ) -RRB- cord-349011-kxhpdvri 273 27 , , , cord-349011-kxhpdvri 273 28 and and CC cord-349011-kxhpdvri 273 29 perhaps perhaps RB cord-349011-kxhpdvri 273 30 twisting twist VBG cord-349011-kxhpdvri 273 31 a a DT cord-349011-kxhpdvri 273 32 few few JJ cord-349011-kxhpdvri 273 33 arms arm NNS cord-349011-kxhpdvri 273 34 to to TO cord-349011-kxhpdvri 273 35 encourage encourage VB cord-349011-kxhpdvri 273 36 colleagues colleague NNS cord-349011-kxhpdvri 273 37 to to TO cord-349011-kxhpdvri 273 38 assume assume VB cord-349011-kxhpdvri 273 39 leadership leadership NN cord-349011-kxhpdvri 273 40 positions position NNS cord-349011-kxhpdvri 273 41 and and CC cord-349011-kxhpdvri 273 42 host host VBP cord-349011-kxhpdvri 273 43 future future JJ cord-349011-kxhpdvri 273 44 CSV csv NN cord-349011-kxhpdvri 273 45 symposia symposium NNS cord-349011-kxhpdvri 273 46 . . . cord-349011-kxhpdvri 274 1 Pipe Pipe NNP cord-349011-kxhpdvri 274 2 and and CC cord-349011-kxhpdvri 274 3 Drum Drum NNP cord-349011-kxhpdvri 274 4 sounded sound VBD cord-349011-kxhpdvri 274 5 once once RB cord-349011-kxhpdvri 274 6 again again RB cord-349011-kxhpdvri 274 7 , , , cord-349011-kxhpdvri 274 8 and and CC cord-349011-kxhpdvri 274 9 we -PRON- PRP cord-349011-kxhpdvri 274 10 marched march VBD cord-349011-kxhpdvri 274 11 out out IN cord-349011-kxhpdvri 274 12 of of IN cord-349011-kxhpdvri 274 13 the the DT cord-349011-kxhpdvri 274 14 Citadel Citadel NNP cord-349011-kxhpdvri 274 15 and and CC cord-349011-kxhpdvri 274 16 down down IN cord-349011-kxhpdvri 274 17 Sackville Sackville NNP cord-349011-kxhpdvri 274 18 Street Street NNP cord-349011-kxhpdvri 274 19 to to IN cord-349011-kxhpdvri 274 20 the the DT cord-349011-kxhpdvri 274 21 historic historic JJ cord-349011-kxhpdvri 274 22 Alexander Alexander NNP cord-349011-kxhpdvri 274 23 Keith Keith NNP cord-349011-kxhpdvri 274 24 's 's POS cord-349011-kxhpdvri 274 25 Brewery Brewery NNP cord-349011-kxhpdvri 274 26 for for IN cord-349011-kxhpdvri 274 27 an an DT cord-349011-kxhpdvri 274 28 evening evening NN cord-349011-kxhpdvri 274 29 featuring feature VBG cord-349011-kxhpdvri 274 30 local local JJ cord-349011-kxhpdvri 274 31 food food NN cord-349011-kxhpdvri 274 32 , , , cord-349011-kxhpdvri 274 33 drink drink NN cord-349011-kxhpdvri 274 34 , , , cord-349011-kxhpdvri 274 35 and and CC cord-349011-kxhpdvri 274 36 music music NN cord-349011-kxhpdvri 274 37 . . . cord-349011-kxhpdvri 275 1 A a DT cord-349011-kxhpdvri 275 2 good good JJ cord-349011-kxhpdvri 275 3 time time NN cord-349011-kxhpdvri 275 4 was be VBD cord-349011-kxhpdvri 275 5 had have VBN cord-349011-kxhpdvri 275 6 by by IN cord-349011-kxhpdvri 275 7 all all DT cord-349011-kxhpdvri 275 8 , , , cord-349011-kxhpdvri 275 9 including include VBG cord-349011-kxhpdvri 275 10 Drs Drs NNP cord-349011-kxhpdvri 275 11 . . . cord-349011-kxhpdvri 276 1 Grandvaux Grandvaux NNP cord-349011-kxhpdvri 276 2 and and CC cord-349011-kxhpdvri 276 3 McCormick McCormick NNP cord-349011-kxhpdvri 276 4 , , , cord-349011-kxhpdvri 276 5 who who WP cord-349011-kxhpdvri 276 6 could could MD cord-349011-kxhpdvri 276 7 be be VB cord-349011-kxhpdvri 276 8 found find VBN cord-349011-kxhpdvri 276 9 relaxing relax VBG cord-349011-kxhpdvri 276 10 in in IN cord-349011-kxhpdvri 276 11 Mr. Mr. NNP cord-349011-kxhpdvri 276 12 Keith Keith NNP cord-349011-kxhpdvri 276 13 's 's POS cord-349011-kxhpdvri 276 14 leather leather NN cord-349011-kxhpdvri 276 15 - - HYPH cord-349011-kxhpdvri 276 16 bound bind VBN cord-349011-kxhpdvri 276 17 office office NN cord-349011-kxhpdvri 276 18 following follow VBG cord-349011-kxhpdvri 276 19 a a DT cord-349011-kxhpdvri 276 20 very very RB cord-349011-kxhpdvri 276 21 successful successful JJ cord-349011-kxhpdvri 276 22 symposium symposium NN cord-349011-kxhpdvri 276 23 ( ( -LRB- cord-349011-kxhpdvri 276 24 Figure Figure NNP cord-349011-kxhpdvri 276 25 7 7 CD cord-349011-kxhpdvri 276 26 ) ) -RRB- cord-349011-kxhpdvri 276 27 , , , cord-349011-kxhpdvri 276 28 and and CC cord-349011-kxhpdvri 276 29 perhaps perhaps RB cord-349011-kxhpdvri 276 30 twisting twist VBG cord-349011-kxhpdvri 276 31 a a DT cord-349011-kxhpdvri 276 32 few few JJ cord-349011-kxhpdvri 276 33 arms arm NNS cord-349011-kxhpdvri 276 34 to to TO cord-349011-kxhpdvri 276 35 encourage encourage VB cord-349011-kxhpdvri 276 36 colleagues colleague NNS cord-349011-kxhpdvri 276 37 to to TO cord-349011-kxhpdvri 276 38 assume assume VB cord-349011-kxhpdvri 276 39 leadership leadership NN cord-349011-kxhpdvri 276 40 positions position NNS cord-349011-kxhpdvri 276 41 and and CC cord-349011-kxhpdvri 276 42 host host VBP cord-349011-kxhpdvri 276 43 future future JJ cord-349011-kxhpdvri 276 44 CSV csv NN cord-349011-kxhpdvri 276 45 symposia symposium NNS cord-349011-kxhpdvri 276 46 . . . cord-349011-kxhpdvri 277 1 Pipe Pipe NNP cord-349011-kxhpdvri 277 2 and and CC cord-349011-kxhpdvri 277 3 Drum Drum NNP cord-349011-kxhpdvri 277 4 sounded sound VBD cord-349011-kxhpdvri 277 5 once once RB cord-349011-kxhpdvri 277 6 again again RB cord-349011-kxhpdvri 277 7 , , , cord-349011-kxhpdvri 277 8 and and CC cord-349011-kxhpdvri 277 9 we -PRON- PRP cord-349011-kxhpdvri 277 10 marched march VBD cord-349011-kxhpdvri 277 11 out out IN cord-349011-kxhpdvri 277 12 of of IN cord-349011-kxhpdvri 277 13 the the DT cord-349011-kxhpdvri 277 14 Citadel Citadel NNP cord-349011-kxhpdvri 277 15 and and CC cord-349011-kxhpdvri 277 16 down down IN cord-349011-kxhpdvri 277 17 Sackville Sackville NNP cord-349011-kxhpdvri 277 18 Street Street NNP cord-349011-kxhpdvri 277 19 to to IN cord-349011-kxhpdvri 277 20 the the DT cord-349011-kxhpdvri 277 21 historic historic JJ cord-349011-kxhpdvri 277 22 Alexander Alexander NNP cord-349011-kxhpdvri 277 23 Keith Keith NNP cord-349011-kxhpdvri 277 24 's 's POS cord-349011-kxhpdvri 277 25 Brewery Brewery NNP cord-349011-kxhpdvri 277 26 for for IN cord-349011-kxhpdvri 277 27 an an DT cord-349011-kxhpdvri 277 28 evening evening NN cord-349011-kxhpdvri 277 29 featuring feature VBG cord-349011-kxhpdvri 277 30 local local JJ cord-349011-kxhpdvri 277 31 food food NN cord-349011-kxhpdvri 277 32 , , , cord-349011-kxhpdvri 277 33 drink drink NN cord-349011-kxhpdvri 277 34 , , , cord-349011-kxhpdvri 277 35 and and CC cord-349011-kxhpdvri 277 36 music music NN cord-349011-kxhpdvri 277 37 . . . cord-349011-kxhpdvri 278 1 A a DT cord-349011-kxhpdvri 278 2 good good JJ cord-349011-kxhpdvri 278 3 time time NN cord-349011-kxhpdvri 278 4 was be VBD cord-349011-kxhpdvri 278 5 had have VBN cord-349011-kxhpdvri 278 6 by by IN cord-349011-kxhpdvri 278 7 all all DT cord-349011-kxhpdvri 278 8 , , , cord-349011-kxhpdvri 278 9 including include VBG cord-349011-kxhpdvri 278 10 Drs Drs NNP cord-349011-kxhpdvri 278 11 . . . cord-349011-kxhpdvri 279 1 Grandvaux Grandvaux NNP cord-349011-kxhpdvri 279 2 and and CC cord-349011-kxhpdvri 279 3 McCormick McCormick NNP cord-349011-kxhpdvri 279 4 , , , cord-349011-kxhpdvri 279 5 who who WP cord-349011-kxhpdvri 279 6 could could MD cord-349011-kxhpdvri 279 7 be be VB cord-349011-kxhpdvri 279 8 found find VBN cord-349011-kxhpdvri 279 9 relaxing relax VBG cord-349011-kxhpdvri 279 10 in in IN cord-349011-kxhpdvri 279 11 Mr. Mr. NNP cord-349011-kxhpdvri 279 12 Keith Keith NNP cord-349011-kxhpdvri 279 13 's 's POS cord-349011-kxhpdvri 279 14 leather leather NN cord-349011-kxhpdvri 279 15 - - HYPH cord-349011-kxhpdvri 279 16 bound bind VBN cord-349011-kxhpdvri 279 17 office office NN cord-349011-kxhpdvri 279 18 following follow VBG cord-349011-kxhpdvri 279 19 a a DT cord-349011-kxhpdvri 279 20 very very RB cord-349011-kxhpdvri 279 21 successful successful JJ cord-349011-kxhpdvri 279 22 symposium symposium NN cord-349011-kxhpdvri 279 23 ( ( -LRB- cord-349011-kxhpdvri 279 24 Figure Figure NNP cord-349011-kxhpdvri 279 25 7 7 CD cord-349011-kxhpdvri 279 26 ) ) -RRB- cord-349011-kxhpdvri 279 27 , , , cord-349011-kxhpdvri 279 28 and and CC cord-349011-kxhpdvri 279 29 perhaps perhaps RB cord-349011-kxhpdvri 279 30 twisting twist VBG cord-349011-kxhpdvri 279 31 a a DT cord-349011-kxhpdvri 279 32 few few JJ cord-349011-kxhpdvri 279 33 arms arm NNS cord-349011-kxhpdvri 279 34 to to TO cord-349011-kxhpdvri 279 35 encourage encourage VB cord-349011-kxhpdvri 279 36 colleagues colleague NNS cord-349011-kxhpdvri 279 37 to to TO cord-349011-kxhpdvri 279 38 assume assume VB cord-349011-kxhpdvri 279 39 leadership leadership NN cord-349011-kxhpdvri 279 40 positions position NNS cord-349011-kxhpdvri 279 41 and and CC cord-349011-kxhpdvri 279 42 host host VBP cord-349011-kxhpdvri 279 43 future future JJ cord-349011-kxhpdvri 279 44 CSV csv NN cord-349011-kxhpdvri 279 45 symposia symposium NNS cord-349011-kxhpdvri 279 46 . . . cord-349011-kxhpdvri 280 1 Author Author NNP cord-349011-kxhpdvri 280 2 Contributions contribution NNS cord-349011-kxhpdvri 280 3 : : : cord-349011-kxhpdvri 281 1 All all DT cord-349011-kxhpdvri 281 2 authors author NNS cord-349011-kxhpdvri 281 3 contributed contribute VBD cord-349011-kxhpdvri 281 4 equally equally RB cord-349011-kxhpdvri 281 5 to to IN cord-349011-kxhpdvri 281 6 the the DT cord-349011-kxhpdvri 281 7 conception conception NN cord-349011-kxhpdvri 281 8 and and CC cord-349011-kxhpdvri 281 9 writing writing NN cord-349011-kxhpdvri 281 10 of of IN cord-349011-kxhpdvri 281 11 this this DT cord-349011-kxhpdvri 281 12 paper paper NN cord-349011-kxhpdvri 281 13 . . . cord-349011-kxhpdvri 282 1 Workshop Workshop NNP cord-349011-kxhpdvri 282 2 of of IN cord-349011-kxhpdvri 282 3 the the DT cord-349011-kxhpdvri 282 4 Canadian Canadian NNP cord-349011-kxhpdvri 282 5 Society Society NNP cord-349011-kxhpdvri 282 6 for for IN cord-349011-kxhpdvri 282 7 Virology Virology NNP cord-349011-kxhpdvri 283 1 An an DT cord-349011-kxhpdvri 283 2 anti anti JJ cord-349011-kxhpdvri 283 3 - - JJ cord-349011-kxhpdvri 283 4 CRISPR CRISPR NNP cord-349011-kxhpdvri 283 5 from from IN cord-349011-kxhpdvri 283 6 a a DT cord-349011-kxhpdvri 283 7 virulent virulent JJ cord-349011-kxhpdvri 283 8 streptococcal streptococcal JJ cord-349011-kxhpdvri 283 9 phage phage NN cord-349011-kxhpdvri 283 10 inhibits inhibit VBZ cord-349011-kxhpdvri 283 11 Streptococcus streptococcus NN cord-349011-kxhpdvri 283 12 pyogenes pyogene NNS cord-349011-kxhpdvri 283 13 Cas9 Cas9 NNP cord-349011-kxhpdvri 283 14 Widespread widespread JJ cord-349011-kxhpdvri 283 15 anti anti JJ cord-349011-kxhpdvri 283 16 - - JJ cord-349011-kxhpdvri 283 17 CRISPR crispr JJ cord-349011-kxhpdvri 283 18 proteins protein NNS cord-349011-kxhpdvri 283 19 in in IN cord-349011-kxhpdvri 283 20 virulent virulent JJ cord-349011-kxhpdvri 283 21 bacteriophages bacteriophage NNS cord-349011-kxhpdvri 283 22 inhibit inhibit VBP cord-349011-kxhpdvri 283 23 a a DT cord-349011-kxhpdvri 283 24 range range NN cord-349011-kxhpdvri 283 25 of of IN cord-349011-kxhpdvri 283 26 Cas9 Cas9 NNP cord-349011-kxhpdvri 283 27 proteins protein NNS cord-349011-kxhpdvri 283 28 CRISPR CRISPR NNP cord-349011-kxhpdvri 283 29 - - HYPH cord-349011-kxhpdvri 283 30 Cas Cas NNP cord-349011-kxhpdvri 283 31 in in IN cord-349011-kxhpdvri 283 32 the the DT cord-349011-kxhpdvri 283 33 laboratory laboratory NN cord-349011-kxhpdvri 283 34 classroom classroom NN cord-349011-kxhpdvri 283 35 Workshop Workshop NNP cord-349011-kxhpdvri 283 36 of of IN cord-349011-kxhpdvri 283 37 the the DT cord-349011-kxhpdvri 283 38 Canadian Canadian NNP cord-349011-kxhpdvri 283 39 Society Society NNP cord-349011-kxhpdvri 283 40 for for IN cord-349011-kxhpdvri 283 41 Virology Virology NNP cord-349011-kxhpdvri 284 1 An an DT cord-349011-kxhpdvri 284 2 anti anti JJ cord-349011-kxhpdvri 284 3 - - JJ cord-349011-kxhpdvri 284 4 CRISPR CRISPR NNP cord-349011-kxhpdvri 284 5 from from IN cord-349011-kxhpdvri 284 6 a a DT cord-349011-kxhpdvri 284 7 virulent virulent JJ cord-349011-kxhpdvri 284 8 streptococcal streptococcal JJ cord-349011-kxhpdvri 284 9 phage phage NN cord-349011-kxhpdvri 284 10 inhibits inhibit VBZ cord-349011-kxhpdvri 284 11 Streptococcus streptococcus NN cord-349011-kxhpdvri 284 12 pyogenes pyogene NNS cord-349011-kxhpdvri 284 13 Cas9 Cas9 NNP cord-349011-kxhpdvri 284 14 Widespread widespread JJ cord-349011-kxhpdvri 284 15 anti anti JJ cord-349011-kxhpdvri 284 16 - - JJ cord-349011-kxhpdvri 284 17 CRISPR crispr JJ cord-349011-kxhpdvri 284 18 proteins protein NNS cord-349011-kxhpdvri 284 19 in in IN cord-349011-kxhpdvri 284 20 virulent virulent JJ cord-349011-kxhpdvri 284 21 bacteriophages bacteriophage NNS cord-349011-kxhpdvri 284 22 inhibit inhibit VBP cord-349011-kxhpdvri 284 23 a a DT cord-349011-kxhpdvri 284 24 range range NN cord-349011-kxhpdvri 284 25 of of IN cord-349011-kxhpdvri 284 26 Cas9 Cas9 NNP cord-349011-kxhpdvri 284 27 proteins protein NNS cord-349011-kxhpdvri 284 28 CRISPR CRISPR NNP cord-349011-kxhpdvri 284 29 - - HYPH cord-349011-kxhpdvri 284 30 Cas Cas NNP cord-349011-kxhpdvri 284 31 in in IN cord-349011-kxhpdvri 284 32 the the DT cord-349011-kxhpdvri 284 33 laboratory laboratory NN cord-349011-kxhpdvri 284 34 classroom classroom NN cord-349011-kxhpdvri 284 35 Lack lack NN cord-349011-kxhpdvri 284 36 of of IN cord-349011-kxhpdvri 284 37 inflammatory inflammatory JJ cord-349011-kxhpdvri 284 38 gene gene NN cord-349011-kxhpdvri 284 39 expression expression NN cord-349011-kxhpdvri 284 40 in in IN cord-349011-kxhpdvri 284 41 bats bat NNS cord-349011-kxhpdvri 284 42 : : : cord-349011-kxhpdvri 285 1 A a DT cord-349011-kxhpdvri 285 2 unique unique JJ cord-349011-kxhpdvri 285 3 role role NN cord-349011-kxhpdvri 285 4 for for IN cord-349011-kxhpdvri 285 5 a a DT cord-349011-kxhpdvri 285 6 transcription transcription NN cord-349011-kxhpdvri 285 7 repressor repressor NN cord-349011-kxhpdvri 285 8 A a NN cord-349011-kxhpdvri 285 9 persistently persistently RB cord-349011-kxhpdvri 285 10 infecting infect VBG cord-349011-kxhpdvri 285 11 coronavirus coronavirus NN cord-349011-kxhpdvri 285 12 in in IN cord-349011-kxhpdvri 285 13 hibernating hibernate VBG cord-349011-kxhpdvri 285 14 Myotis Myotis NNP cord-349011-kxhpdvri 285 15 lucifugus lucifugus NNP cord-349011-kxhpdvri 285 16 , , , cord-349011-kxhpdvri 285 17 the the DT cord-349011-kxhpdvri 285 18 North north JJ cord-349011-kxhpdvri 285 19 American american JJ cord-349011-kxhpdvri 285 20 little little JJ cord-349011-kxhpdvri 285 21 brown brown JJ cord-349011-kxhpdvri 285 22 bat bat NN cord-349011-kxhpdvri 285 23 Isolation isolation NN cord-349011-kxhpdvri 285 24 , , , cord-349011-kxhpdvri 285 25 characterization characterization NN cord-349011-kxhpdvri 285 26 and and CC cord-349011-kxhpdvri 285 27 prevalence prevalence NN cord-349011-kxhpdvri 285 28 of of IN cord-349011-kxhpdvri 285 29 a a DT cord-349011-kxhpdvri 285 30 novel novel JJ cord-349011-kxhpdvri 285 31 Gammaherpesvirus Gammaherpesvirus NNP cord-349011-kxhpdvri 285 32 in in IN cord-349011-kxhpdvri 285 33 Eptesicus Eptesicus NNP cord-349011-kxhpdvri 285 34 fuscus fuscus NN cord-349011-kxhpdvri 285 35 , , , cord-349011-kxhpdvri 285 36 the the DT cord-349011-kxhpdvri 285 37 North north JJ cord-349011-kxhpdvri 285 38 American american JJ cord-349011-kxhpdvri 285 39 big big JJ cord-349011-kxhpdvri 285 40 brown brown JJ cord-349011-kxhpdvri 285 41 bat bat NN cord-349011-kxhpdvri 286 1 Environmentally environmentally RB cord-349011-kxhpdvri 286 2 persistent persistent JJ cord-349011-kxhpdvri 286 3 pathogens pathogen NNS cord-349011-kxhpdvri 286 4 present present VBP cord-349011-kxhpdvri 286 5 unique unique JJ cord-349011-kxhpdvri 286 6 challenges challenge NNS cord-349011-kxhpdvri 286 7 for for IN cord-349011-kxhpdvri 286 8 studies study NNS cord-349011-kxhpdvri 286 9 of of IN cord-349011-kxhpdvri 286 10 host host NN cord-349011-kxhpdvri 286 11 - - HYPH cord-349011-kxhpdvri 286 12 pathogen pathogen NN cord-349011-kxhpdvri 286 13 interactions interaction NNS cord-349011-kxhpdvri 286 14 : : : cord-349011-kxhpdvri 286 15 Reply reply VB cord-349011-kxhpdvri 286 16 to to IN cord-349011-kxhpdvri 286 17 Field Field NNP cord-349011-kxhpdvri 286 18 Generation Generation NNP cord-349011-kxhpdvri 286 19 and and CC cord-349011-kxhpdvri 286 20 Characterization characterization NN cord-349011-kxhpdvri 286 21 of of IN cord-349011-kxhpdvri 286 22 Eptesicus Eptesicus NNP cord-349011-kxhpdvri 286 23 fuscus fuscus NN cord-349011-kxhpdvri 286 24 ( ( -LRB- cord-349011-kxhpdvri 286 25 Big big JJ cord-349011-kxhpdvri 286 26 brown brown JJ cord-349011-kxhpdvri 286 27 bat bat NN cord-349011-kxhpdvri 286 28 ) ) -RRB- cord-349011-kxhpdvri 286 29 kidney kidney NN cord-349011-kxhpdvri 286 30 cell cell NN cord-349011-kxhpdvri 286 31 lines line NNS cord-349011-kxhpdvri 286 32 immortalized immortalize VBN cord-349011-kxhpdvri 286 33 using use VBG cord-349011-kxhpdvri 286 34 the the DT cord-349011-kxhpdvri 286 35 Myotis Myotis NNP cord-349011-kxhpdvri 286 36 polyomavirus polyomavirus JJ cord-349011-kxhpdvri 286 37 large large JJ cord-349011-kxhpdvri 286 38 T t NN cord-349011-kxhpdvri 286 39 - - HYPH cord-349011-kxhpdvri 286 40 antigen antigen NN cord-349011-kxhpdvri 286 41 Efficacy Efficacy NNP cord-349011-kxhpdvri 286 42 and and CC cord-349011-kxhpdvri 286 43 effectiveness effectiveness NN cord-349011-kxhpdvri 286 44 of of IN cord-349011-kxhpdvri 286 45 an an DT cord-349011-kxhpdvri 286 46 rVSV rvsv JJ cord-349011-kxhpdvri 286 47 - - HYPH cord-349011-kxhpdvri 286 48 vectored vectore VBN cord-349011-kxhpdvri 286 49 vaccine vaccine NN cord-349011-kxhpdvri 286 50 expressing express VBG cord-349011-kxhpdvri 286 51 Ebola Ebola NNP cord-349011-kxhpdvri 286 52 surface surface NN cord-349011-kxhpdvri 286 53 glycoprotein glycoprotein NN cord-349011-kxhpdvri 286 54 : : : cord-349011-kxhpdvri 286 55 Interim interim JJ cord-349011-kxhpdvri 286 56 results result NNS cord-349011-kxhpdvri 286 57 from from IN cord-349011-kxhpdvri 286 58 the the DT cord-349011-kxhpdvri 286 59 Guinea Guinea NNP cord-349011-kxhpdvri 286 60 ring ring NN cord-349011-kxhpdvri 286 61 vaccination vaccination NN cord-349011-kxhpdvri 286 62 cluster cluster NN cord-349011-kxhpdvri 286 63 - - HYPH cord-349011-kxhpdvri 286 64 randomised randomised JJ cord-349011-kxhpdvri 286 65 trial trial NN cord-349011-kxhpdvri 286 66 Properties property NNS cord-349011-kxhpdvri 286 67 of of IN cord-349011-kxhpdvri 286 68 replication replication NN cord-349011-kxhpdvri 286 69 - - HYPH cord-349011-kxhpdvri 286 70 competent competent JJ cord-349011-kxhpdvri 286 71 vesicular vesicular JJ cord-349011-kxhpdvri 286 72 stomatitis stomatitis NN cord-349011-kxhpdvri 286 73 virus virus NN cord-349011-kxhpdvri 286 74 vectors vector NNS cord-349011-kxhpdvri 286 75 expressing express VBG cord-349011-kxhpdvri 286 76 glycoproteins glycoprotein NNS cord-349011-kxhpdvri 286 77 of of IN cord-349011-kxhpdvri 286 78 filoviruses filovirus NNS cord-349011-kxhpdvri 286 79 and and CC cord-349011-kxhpdvri 286 80 arenaviruses arenavirus NNS cord-349011-kxhpdvri 286 81 Development Development NNP cord-349011-kxhpdvri 286 82 of of IN cord-349011-kxhpdvri 286 83 a a DT cord-349011-kxhpdvri 286 84 new new JJ cord-349011-kxhpdvri 286 85 vaccine vaccine NN cord-349011-kxhpdvri 286 86 for for IN cord-349011-kxhpdvri 286 87 the the DT cord-349011-kxhpdvri 286 88 prevention prevention NN cord-349011-kxhpdvri 286 89 of of IN cord-349011-kxhpdvri 286 90 Lassa Lassa NNP cord-349011-kxhpdvri 286 91 fever fever NN cord-349011-kxhpdvri 286 92 Vesicular Vesicular NNP cord-349011-kxhpdvri 286 93 stomatitis stomatitis NN cord-349011-kxhpdvri 286 94 virus virus NN cord-349011-kxhpdvri 286 95 - - HYPH cord-349011-kxhpdvri 286 96 based base VBN cord-349011-kxhpdvri 286 97 vaccines vaccine NNS cord-349011-kxhpdvri 286 98 against against IN cord-349011-kxhpdvri 286 99 Lassa Lassa NNP cord-349011-kxhpdvri 286 100 and and CC cord-349011-kxhpdvri 286 101 Ebola Ebola NNP cord-349011-kxhpdvri 286 102 viruses virus NNS cord-349011-kxhpdvri 287 1 A a DT cord-349011-kxhpdvri 287 2 recombinant recombinant JJ cord-349011-kxhpdvri 287 3 vesicular vesicular JJ cord-349011-kxhpdvri 287 4 stomatitis stomatitis NN cord-349011-kxhpdvri 287 5 virus virus NN cord-349011-kxhpdvri 287 6 - - HYPH cord-349011-kxhpdvri 287 7 based base VBN cord-349011-kxhpdvri 287 8 Lassa Lassa NNP cord-349011-kxhpdvri 287 9 fever fever NN cord-349011-kxhpdvri 287 10 vaccine vaccine NN cord-349011-kxhpdvri 287 11 protects protect VBZ cord-349011-kxhpdvri 287 12 guinea guinea NN cord-349011-kxhpdvri 287 13 pigs pig NNS cord-349011-kxhpdvri 287 14 and and CC cord-349011-kxhpdvri 287 15 macaques macaque NNS cord-349011-kxhpdvri 287 16 against against IN cord-349011-kxhpdvri 287 17 challenge challenge NN cord-349011-kxhpdvri 287 18 with with IN cord-349011-kxhpdvri 287 19 geographically geographically RB cord-349011-kxhpdvri 287 20 and and CC cord-349011-kxhpdvri 287 21 genetically genetically RB cord-349011-kxhpdvri 287 22 distinct distinct JJ cord-349011-kxhpdvri 287 23 Lassa Lassa NNP cord-349011-kxhpdvri 287 24 viruses virus NNS cord-349011-kxhpdvri 288 1 Will Will MD cord-349011-kxhpdvri 288 2 Travel travel VB cord-349011-kxhpdvri 288 3 : : : cord-349011-kxhpdvri 289 1 Structural structural JJ cord-349011-kxhpdvri 289 2 Basis basis NN cord-349011-kxhpdvri 289 3 of of IN cord-349011-kxhpdvri 289 4 Membrane Membrane NNP cord-349011-kxhpdvri 289 5 Budding Budding NNP cord-349011-kxhpdvri 289 6 During during IN cord-349011-kxhpdvri 289 7 Nuclear Nuclear NNP cord-349011-kxhpdvri 289 8 Egress Egress NNP cord-349011-kxhpdvri 289 9 in in IN cord-349011-kxhpdvri 289 10 Herpesviruses Herpesviruses NNP cord-349011-kxhpdvri 289 11 . . . cord-349011-kxhpdvri 290 1 Adv Adv NNP cord-349011-kxhpdvri 290 2 . . . cord-349011-kxhpdvri 291 1 Virus Virus NNP cord-349011-kxhpdvri 291 2 Res Res NNP cord-349011-kxhpdvri 291 3 Nuclear Nuclear NNP cord-349011-kxhpdvri 291 4 Egress Egress NNP cord-349011-kxhpdvri 291 5 of of IN cord-349011-kxhpdvri 291 6 Herpesviruses Herpesviruses NNP cord-349011-kxhpdvri 291 7 : : : cord-349011-kxhpdvri 292 1 The the DT cord-349011-kxhpdvri 292 2 Prototypic Prototypic NNP cord-349011-kxhpdvri 292 3 Vesicular Vesicular NNP cord-349011-kxhpdvri 292 4 Nucleocytoplasmic Nucleocytoplasmic NNP cord-349011-kxhpdvri 292 5 Transport Transport NNP cord-349011-kxhpdvri 293 1 The the DT cord-349011-kxhpdvri 293 2 herpes herpe NNS cord-349011-kxhpdvri 293 3 simplex simplex NN cord-349011-kxhpdvri 293 4 virus virus NN cord-349011-kxhpdvri 293 5 2 2 CD cord-349011-kxhpdvri 293 6 UL21 UL21 NNP cord-349011-kxhpdvri 293 7 protein protein NN cord-349011-kxhpdvri 293 8 is be VBZ cord-349011-kxhpdvri 293 9 essential essential JJ cord-349011-kxhpdvri 293 10 for for IN cord-349011-kxhpdvri 293 11 virus virus NN cord-349011-kxhpdvri 293 12 propagation propagation NN cord-349011-kxhpdvri 293 13 Reovirus Reovirus NNP cord-349011-kxhpdvri 293 14 therapy therapy NN cord-349011-kxhpdvri 293 15 of of IN cord-349011-kxhpdvri 293 16 tumors tumor NNS cord-349011-kxhpdvri 293 17 with with IN cord-349011-kxhpdvri 293 18 activated activate VBN cord-349011-kxhpdvri 293 19 Ras Ras NNP cord-349011-kxhpdvri 293 20 pathway pathway NN cord-349011-kxhpdvri 293 21 Reovirus Reovirus NNP cord-349011-kxhpdvri 293 22 in in IN cord-349011-kxhpdvri 293 23 cancer cancer NN cord-349011-kxhpdvri 293 24 therapy therapy NN cord-349011-kxhpdvri 293 25 : : : cord-349011-kxhpdvri 294 1 An an DT cord-349011-kxhpdvri 294 2 evidence evidence NN cord-349011-kxhpdvri 294 3 - - HYPH cord-349011-kxhpdvri 294 4 based base VBN cord-349011-kxhpdvri 294 5 review review NN cord-349011-kxhpdvri 294 6 Potential potential NN cord-349011-kxhpdvri 294 7 for for IN cord-349011-kxhpdvri 294 8 Improving improve VBG cord-349011-kxhpdvri 294 9 Potency Potency NNP cord-349011-kxhpdvri 294 10 and and CC cord-349011-kxhpdvri 294 11 Specificity Specificity NNP cord-349011-kxhpdvri 294 12 of of IN cord-349011-kxhpdvri 294 13 Reovirus Reovirus NNP cord-349011-kxhpdvri 294 14 Oncolysis Oncolysis NNP cord-349011-kxhpdvri 294 15 with with IN cord-349011-kxhpdvri 294 16 Next Next NNP cord-349011-kxhpdvri 294 17 - - HYPH cord-349011-kxhpdvri 294 18 Generation Generation NNP cord-349011-kxhpdvri 294 19 Reovirus Reovirus NNP cord-349011-kxhpdvri 294 20 Variants Variants NNPS cord-349011-kxhpdvri 294 21 Reovirus Reovirus NNP cord-349011-kxhpdvri 294 22 variants variant NNS cord-349011-kxhpdvri 294 23 with with IN cord-349011-kxhpdvri 294 24 mutations mutation NNS cord-349011-kxhpdvri 294 25 in in IN cord-349011-kxhpdvri 294 26 genome genome NN cord-349011-kxhpdvri 294 27 segments segment NNS cord-349011-kxhpdvri 294 28 S1 S1 NNP cord-349011-kxhpdvri 294 29 and and CC cord-349011-kxhpdvri 294 30 L2 L2 NNP cord-349011-kxhpdvri 294 31 exhibit exhibit NN cord-349011-kxhpdvri 294 32 enhanced enhanced JJ cord-349011-kxhpdvri 294 33 virion virion NN cord-349011-kxhpdvri 294 34 infectivity infectivity NN cord-349011-kxhpdvri 294 35 and and CC cord-349011-kxhpdvri 294 36 superior superior JJ cord-349011-kxhpdvri 294 37 oncolysis oncolysis NN cord-349011-kxhpdvri 294 38 Reduction reduction NN cord-349011-kxhpdvri 294 39 of of IN cord-349011-kxhpdvri 294 40 virion virion NN cord-349011-kxhpdvri 294 41 - - HYPH cord-349011-kxhpdvri 294 42 associated associate VBN cord-349011-kxhpdvri 294 43 σ1 σ1 NNP cord-349011-kxhpdvri 294 44 fibers fiber NNS cord-349011-kxhpdvri 294 45 on on IN cord-349011-kxhpdvri 294 46 oncolytic oncolytic JJ cord-349011-kxhpdvri 294 47 reovirus reovirus NNP cord-349011-kxhpdvri 294 48 variants variant NNS cord-349011-kxhpdvri 294 49 promotes promote VBZ cord-349011-kxhpdvri 294 50 adaptation adaptation NN cord-349011-kxhpdvri 294 51 toward toward IN cord-349011-kxhpdvri 294 52 tumorigenic tumorigenic JJ cord-349011-kxhpdvri 294 53 cells cell NNS cord-349011-kxhpdvri 295 1 An an DT cord-349011-kxhpdvri 295 2 updated update VBN cord-349011-kxhpdvri 295 3 evolutionary evolutionary JJ cord-349011-kxhpdvri 295 4 classification classification NN cord-349011-kxhpdvri 295 5 of of IN cord-349011-kxhpdvri 295 6 CRISPR CRISPR NNP cord-349011-kxhpdvri 295 7 - - HYPH cord-349011-kxhpdvri 295 8 Cas Cas NNP cord-349011-kxhpdvri 295 9 systems system NNS cord-349011-kxhpdvri 295 10 A a DT cord-349011-kxhpdvri 295 11 chemical chemical NN cord-349011-kxhpdvri 295 12 defence defence NN cord-349011-kxhpdvri 295 13 against against IN cord-349011-kxhpdvri 295 14 phage phage NN cord-349011-kxhpdvri 295 15 infection infection NN cord-349011-kxhpdvri 295 16 Systematic Systematic NNP cord-349011-kxhpdvri 295 17 Review Review NNP cord-349011-kxhpdvri 295 18 and and CC cord-349011-kxhpdvri 295 19 Meta Meta NNP cord-349011-kxhpdvri 295 20 - - HYPH cord-349011-kxhpdvri 295 21 analysis analysis NN cord-349011-kxhpdvri 295 22 : : : cord-349011-kxhpdvri 295 23 Fecal Fecal NNP cord-349011-kxhpdvri 295 24 Microbiota Microbiota NNP cord-349011-kxhpdvri 295 25 Transplantation Transplantation NNP cord-349011-kxhpdvri 295 26 for for IN cord-349011-kxhpdvri 295 27 Treatment Treatment NNP cord-349011-kxhpdvri 295 28 of of IN cord-349011-kxhpdvri 295 29 Active active JJ cord-349011-kxhpdvri 295 30 Ulcerative Ulcerative NNP cord-349011-kxhpdvri 295 31 Colitis Colitis NNP cord-349011-kxhpdvri 295 32 Clinical clinical JJ cord-349011-kxhpdvri 295 33 Inquiries inquiry NNS cord-349011-kxhpdvri 296 1 : : : cord-349011-kxhpdvri 296 2 How how WRB cord-349011-kxhpdvri 296 3 effective effective JJ cord-349011-kxhpdvri 296 4 and and CC cord-349011-kxhpdvri 296 5 safe safe JJ cord-349011-kxhpdvri 296 6 is be VBZ cord-349011-kxhpdvri 296 7 fecal fecal JJ cord-349011-kxhpdvri 296 8 microbial microbial JJ cord-349011-kxhpdvri 296 9 transplant transplant NN cord-349011-kxhpdvri 296 10 in in IN cord-349011-kxhpdvri 296 11 preventing prevent VBG cord-349011-kxhpdvri 296 12 C c NN cord-349011-kxhpdvri 296 13 difficile difficile NN cord-349011-kxhpdvri 296 14 recurrence recurrence NN cord-349011-kxhpdvri 296 15 Bacteriophage Bacteriophage NNP cord-349011-kxhpdvri 296 16 transfer transfer NN cord-349011-kxhpdvri 296 17 during during IN cord-349011-kxhpdvri 296 18 faecal faecal JJ cord-349011-kxhpdvri 296 19 microbiota microbiota NN cord-349011-kxhpdvri 296 20 transplantation transplantation NN cord-349011-kxhpdvri 296 21 in in IN cord-349011-kxhpdvri 296 22 Clostridium clostridium NN cord-349011-kxhpdvri 296 23 difficile difficile NN cord-349011-kxhpdvri 296 24 infection infection NN cord-349011-kxhpdvri 296 25 is be VBZ cord-349011-kxhpdvri 296 26 associated associate VBN cord-349011-kxhpdvri 296 27 with with IN cord-349011-kxhpdvri 296 28 treatment treatment NN cord-349011-kxhpdvri 296 29 outcome outcome NN cord-349011-kxhpdvri 297 1 A a DT cord-349011-kxhpdvri 297 2 highly highly RB cord-349011-kxhpdvri 297 3 abundant abundant JJ cord-349011-kxhpdvri 297 4 bacteriophage bacteriophage NN cord-349011-kxhpdvri 297 5 discovered discover VBN cord-349011-kxhpdvri 297 6 in in IN cord-349011-kxhpdvri 297 7 the the DT cord-349011-kxhpdvri 297 8 unknown unknown JJ cord-349011-kxhpdvri 297 9 sequences sequence NNS cord-349011-kxhpdvri 297 10 of of IN cord-349011-kxhpdvri 297 11 human human JJ cord-349011-kxhpdvri 297 12 faecal faecal JJ cord-349011-kxhpdvri 297 13 metagenomes metagenomes NNP cord-349011-kxhpdvri 297 14 Multi Multi NNP cord-349011-kxhpdvri 297 15 - - HYPH cord-349011-kxhpdvri 297 16 omics omic NNS cord-349011-kxhpdvri 297 17 differentially differentially RB cord-349011-kxhpdvri 297 18 classify classify VBP cord-349011-kxhpdvri 297 19 disease disease NN cord-349011-kxhpdvri 297 20 state state NN cord-349011-kxhpdvri 297 21 and and CC cord-349011-kxhpdvri 297 22 treatment treatment NN cord-349011-kxhpdvri 297 23 outcome outcome NN cord-349011-kxhpdvri 297 24 in in IN cord-349011-kxhpdvri 297 25 pediatric pediatric JJ cord-349011-kxhpdvri 297 26 Crohn Crohn NNP cord-349011-kxhpdvri 297 27 's 's POS cord-349011-kxhpdvri 297 28 disease disease NN cord-349011-kxhpdvri 297 29 Identification Identification NNP cord-349011-kxhpdvri 297 30 and and CC cord-349011-kxhpdvri 297 31 Characterization Characterization NNP cord-349011-kxhpdvri 297 32 of of IN cord-349011-kxhpdvri 297 33 Type Type NNP cord-349011-kxhpdvri 297 34 IV IV NNP cord-349011-kxhpdvri 297 35 Pili Pili NNP cord-349011-kxhpdvri 297 36 as as IN cord-349011-kxhpdvri 297 37 the the DT cord-349011-kxhpdvri 297 38 Cellular Cellular NNP cord-349011-kxhpdvri 297 39 Receptor Receptor NNP cord-349011-kxhpdvri 297 40 of of IN cord-349011-kxhpdvri 297 41 Broad Broad NNP cord-349011-kxhpdvri 297 42 Host Host NNP cord-349011-kxhpdvri 297 43 Range Range NNP cord-349011-kxhpdvri 297 44 Stenotrophomonas Stenotrophomonas NNP cord-349011-kxhpdvri 297 45 maltophilia maltophilia NN cord-349011-kxhpdvri 297 46 Bacteriophages Bacteriophages NNPS cord-349011-kxhpdvri 297 47 DLP1 DLP1 NNP cord-349011-kxhpdvri 297 48 and and CC cord-349011-kxhpdvri 297 49 DLP2 DLP2 NNP cord-349011-kxhpdvri 298 1 The the DT cord-349011-kxhpdvri 298 2 Pneumonia Pneumonia NNP cord-349011-kxhpdvri 298 3 Etiology Etiology NNP cord-349011-kxhpdvri 298 4 Research Research NNP cord-349011-kxhpdvri 298 5 for for IN cord-349011-kxhpdvri 298 6 Child Child NNP cord-349011-kxhpdvri 298 7 Health Health NNP cord-349011-kxhpdvri 298 8 Project Project NNP cord-349011-kxhpdvri 298 9 : : : cord-349011-kxhpdvri 299 1 A a DT cord-349011-kxhpdvri 299 2 21st 21st JJ cord-349011-kxhpdvri 299 3 century century NN cord-349011-kxhpdvri 299 4 childhood childhood NN cord-349011-kxhpdvri 299 5 pneumonia pneumonia NN cord-349011-kxhpdvri 299 6 etiology etiology NN cord-349011-kxhpdvri 299 7 study study NN cord-349011-kxhpdvri 299 8 Global global JJ cord-349011-kxhpdvri 299 9 burden burden NN cord-349011-kxhpdvri 299 10 of of IN cord-349011-kxhpdvri 299 11 acute acute JJ cord-349011-kxhpdvri 299 12 lower low JJR cord-349011-kxhpdvri 299 13 respiratory respiratory JJ cord-349011-kxhpdvri 299 14 infections infection NNS cord-349011-kxhpdvri 299 15 due due JJ cord-349011-kxhpdvri 299 16 to to IN cord-349011-kxhpdvri 299 17 respiratory respiratory JJ cord-349011-kxhpdvri 299 18 syncytial syncytial JJ cord-349011-kxhpdvri 299 19 virus virus NN cord-349011-kxhpdvri 299 20 in in IN cord-349011-kxhpdvri 299 21 young young JJ cord-349011-kxhpdvri 299 22 children child NNS cord-349011-kxhpdvri 299 23 : : : cord-349011-kxhpdvri 300 1 A a DT cord-349011-kxhpdvri 300 2 systematic systematic JJ cord-349011-kxhpdvri 300 3 review review NN cord-349011-kxhpdvri 300 4 and and CC cord-349011-kxhpdvri 300 5 meta meta NNP cord-349011-kxhpdvri 300 6 - - HYPH cord-349011-kxhpdvri 300 7 analysis analysis NN cord-349011-kxhpdvri 300 8 Quantitative Quantitative NNP cord-349011-kxhpdvri 300 9 Evaluation Evaluation NNP cord-349011-kxhpdvri 300 10 of of IN cord-349011-kxhpdvri 300 11 Protein Protein NNP cord-349011-kxhpdvri 300 12 Heterogeneity Heterogeneity NNP cord-349011-kxhpdvri 300 13 within within IN cord-349011-kxhpdvri 300 14 Herpes Herpes NNP cord-349011-kxhpdvri 300 15 Simplex Simplex NNP cord-349011-kxhpdvri 300 16 Virus Virus NNP cord-349011-kxhpdvri 300 17 1 1 CD cord-349011-kxhpdvri 300 18 Particles particle NNS cord-349011-kxhpdvri 300 19 Flow flow VBP cord-349011-kxhpdvri 300 20 Virometry Virometry NNP cord-349011-kxhpdvri 300 21 : : : cord-349011-kxhpdvri 300 22 A a DT cord-349011-kxhpdvri 300 23 Powerful powerful JJ cord-349011-kxhpdvri 300 24 Tool tool NN cord-349011-kxhpdvri 300 25 to to TO cord-349011-kxhpdvri 300 26 Functionally functionally RB cord-349011-kxhpdvri 300 27 Characterize characterize VB cord-349011-kxhpdvri 300 28 Viruses Viruses NNPS cord-349011-kxhpdvri 300 29 Analysis Analysis NNP cord-349011-kxhpdvri 300 30 of of IN cord-349011-kxhpdvri 300 31 herpes herpes NNP cord-349011-kxhpdvri 300 32 simplex simplex NNP cord-349011-kxhpdvri 300 33 virus virus NN cord-349011-kxhpdvri 300 34 type type NN cord-349011-kxhpdvri 300 35 I -PRON- PRP cord-349011-kxhpdvri 300 36 nuclear nuclear JJ cord-349011-kxhpdvri 300 37 particles particle NNS cord-349011-kxhpdvri 300 38 by by IN cord-349011-kxhpdvri 300 39 flow flow NN cord-349011-kxhpdvri 300 40 cytometry cytometry NN cord-349011-kxhpdvri 300 41 Genomic Genomic NNP cord-349011-kxhpdvri 300 42 Analysis Analysis NNP cord-349011-kxhpdvri 300 43 , , , cord-349011-kxhpdvri 300 44 Phenotype Phenotype NNP cord-349011-kxhpdvri 300 45 , , , cord-349011-kxhpdvri 300 46 and and CC cord-349011-kxhpdvri 300 47 Virulence virulence NN cord-349011-kxhpdvri 300 48 of of IN cord-349011-kxhpdvri 300 49 the the DT cord-349011-kxhpdvri 300 50 Historical historical JJ cord-349011-kxhpdvri 300 51 Brazilian Brazilian NNP cord-349011-kxhpdvri 300 52 Smallpox Smallpox NNP cord-349011-kxhpdvri 300 53 Vaccine Vaccine NNP cord-349011-kxhpdvri 300 54 Strain Strain NNP cord-349011-kxhpdvri 300 55 IOC IOC NNP cord-349011-kxhpdvri 300 56 : : : cord-349011-kxhpdvri 301 1 Implications implication NNS cord-349011-kxhpdvri 301 2 for for IN cord-349011-kxhpdvri 301 3 the the DT cord-349011-kxhpdvri 301 4 Origins Origins NNPS cord-349011-kxhpdvri 301 5 and and CC cord-349011-kxhpdvri 301 6 Evolutionary Evolutionary NNP cord-349011-kxhpdvri 301 7 Relationships Relationships NNPS cord-349011-kxhpdvri 301 8 of of IN cord-349011-kxhpdvri 301 9 Vaccinia Vaccinia NNP cord-349011-kxhpdvri 301 10 Virus Virus NNP cord-349011-kxhpdvri 301 11 Genome Genome NNP cord-349011-kxhpdvri 301 12 of of IN cord-349011-kxhpdvri 301 13 horsepox horsepox NNP cord-349011-kxhpdvri 301 14 virus virus NN cord-349011-kxhpdvri 302 1 An an DT cord-349011-kxhpdvri 302 2 Early early JJ cord-349011-kxhpdvri 302 3 American American NNP cord-349011-kxhpdvri 302 4 Smallpox Smallpox NNP cord-349011-kxhpdvri 302 5 Vaccine Vaccine NNP cord-349011-kxhpdvri 302 6 Based Based NNP cord-349011-kxhpdvri 302 7 on on IN cord-349011-kxhpdvri 302 8 Horsepox Horsepox NNP cord-349011-kxhpdvri 302 9 Equination Equination NNP cord-349011-kxhpdvri 302 10 ( ( -LRB- cord-349011-kxhpdvri 302 11 inoculation inoculation NN cord-349011-kxhpdvri 302 12 of of IN cord-349011-kxhpdvri 302 13 horsepox horsepox NN cord-349011-kxhpdvri 302 14 ) ) -RRB- cord-349011-kxhpdvri 302 15 : : : cord-349011-kxhpdvri 303 1 An an DT cord-349011-kxhpdvri 303 2 early early JJ cord-349011-kxhpdvri 303 3 alternative alternative NN cord-349011-kxhpdvri 303 4 to to IN cord-349011-kxhpdvri 303 5 vaccination vaccination NN cord-349011-kxhpdvri 303 6 ( ( -LRB- cord-349011-kxhpdvri 303 7 inoculation inoculation NN cord-349011-kxhpdvri 303 8 of of IN cord-349011-kxhpdvri 303 9 cowpox cowpox NN cord-349011-kxhpdvri 303 10 ) ) -RRB- cord-349011-kxhpdvri 303 11 and and CC cord-349011-kxhpdvri 303 12 the the DT cord-349011-kxhpdvri 303 13 potential potential JJ cord-349011-kxhpdvri 303 14 role role NN cord-349011-kxhpdvri 303 15 of of IN cord-349011-kxhpdvri 303 16 horsepox horsepox NNP cord-349011-kxhpdvri 303 17 virus virus NN cord-349011-kxhpdvri 303 18 in in IN cord-349011-kxhpdvri 303 19 the the DT cord-349011-kxhpdvri 303 20 origin origin NN cord-349011-kxhpdvri 303 21 of of IN cord-349011-kxhpdvri 303 22 the the DT cord-349011-kxhpdvri 303 23 smallpox smallpox NN cord-349011-kxhpdvri 303 24 vaccine vaccine NN cord-349011-kxhpdvri 303 25 Construction construction NN cord-349011-kxhpdvri 303 26 of of IN cord-349011-kxhpdvri 303 27 an an DT cord-349011-kxhpdvri 303 28 infectious infectious JJ cord-349011-kxhpdvri 303 29 horsepox horsepox NNP cord-349011-kxhpdvri 303 30 virus virus NN cord-349011-kxhpdvri 303 31 vaccine vaccine NN cord-349011-kxhpdvri 303 32 from from IN cord-349011-kxhpdvri 303 33 chemically chemically RB cord-349011-kxhpdvri 303 34 synthesized synthesize VBN cord-349011-kxhpdvri 303 35 DNA dna NN cord-349011-kxhpdvri 303 36 fragments fragment NNS cord-349011-kxhpdvri 304 1 HIV-1 HIV-1 NNP cord-349011-kxhpdvri 304 2 Nef Nef NNP cord-349011-kxhpdvri 304 3 sequesters sequester VBZ cord-349011-kxhpdvri 304 4 MHC- MHC- NNP cord-349011-kxhpdvri 305 1 I -PRON- PRP cord-349011-kxhpdvri 305 2 intracellularly intracellularly RB cord-349011-kxhpdvri 305 3 by by IN cord-349011-kxhpdvri 305 4 targeting target VBG cord-349011-kxhpdvri 305 5 early early JJ cord-349011-kxhpdvri 305 6 stages stage NNS cord-349011-kxhpdvri 305 7 of of IN cord-349011-kxhpdvri 305 8 endocytosis endocytosis NN cord-349011-kxhpdvri 305 9 and and CC cord-349011-kxhpdvri 305 10 recycling recycling NN cord-349011-kxhpdvri 306 1 Where where WRB cord-349011-kxhpdvri 306 2 in in IN cord-349011-kxhpdvri 306 3 the the DT cord-349011-kxhpdvri 306 4 Cell cell NN cord-349011-kxhpdvri 306 5 Are be VBP cord-349011-kxhpdvri 306 6 You -PRON- PRP cord-349011-kxhpdvri 306 7 ? ? . cord-349011-kxhpdvri 307 1 Probing probe VBG cord-349011-kxhpdvri 307 2 HIV-1 HIV-1 NNP cord-349011-kxhpdvri 307 3 Host Host NNP cord-349011-kxhpdvri 307 4 Interactions Interactions NNPS cord-349011-kxhpdvri 307 5 through through IN cord-349011-kxhpdvri 307 6 Advanced Advanced NNP cord-349011-kxhpdvri 307 7 Imaging Imaging NNP cord-349011-kxhpdvri 307 8 Techniques Techniques NNPS cord-349011-kxhpdvri 307 9 miR-122 miR-122 NNP cord-349011-kxhpdvri 307 10 does do VBZ cord-349011-kxhpdvri 307 11 not not RB cord-349011-kxhpdvri 307 12 impact impact VB cord-349011-kxhpdvri 307 13 recognition recognition NN cord-349011-kxhpdvri 307 14 of of IN cord-349011-kxhpdvri 307 15 the the DT cord-349011-kxhpdvri 307 16 HCV HCV NNP cord-349011-kxhpdvri 307 17 genome genome NN cord-349011-kxhpdvri 307 18 by by IN cord-349011-kxhpdvri 307 19 innate innate JJ cord-349011-kxhpdvri 307 20 sensors sensor NNS cord-349011-kxhpdvri 307 21 of of IN cord-349011-kxhpdvri 307 22 RNA RNA NNP cord-349011-kxhpdvri 307 23 but but CC cord-349011-kxhpdvri 307 24 rather rather RB cord-349011-kxhpdvri 307 25 protects protect VBZ cord-349011-kxhpdvri 307 26 the the DT cord-349011-kxhpdvri 307 27 5 5 CD cord-349011-kxhpdvri 307 28 end end NN cord-349011-kxhpdvri 307 29 from from IN cord-349011-kxhpdvri 307 30 the the DT cord-349011-kxhpdvri 307 31 cellular cellular JJ cord-349011-kxhpdvri 307 32 pyrophosphatases pyrophosphatase NNS cord-349011-kxhpdvri 307 33 , , , cord-349011-kxhpdvri 307 34 DOM3Z dom3z NN cord-349011-kxhpdvri 307 35 and and CC cord-349011-kxhpdvri 307 36 DUSP11 dusp11 NN cord-349011-kxhpdvri 308 1 Influenza Influenza NNP cord-349011-kxhpdvri 308 2 A a DT cord-349011-kxhpdvri 308 3 virus virus NN cord-349011-kxhpdvri 308 4 cap cap NN cord-349011-kxhpdvri 308 5 - - HYPH cord-349011-kxhpdvri 308 6 snatches snatch NNS cord-349011-kxhpdvri 308 7 host host NN cord-349011-kxhpdvri 308 8 RNAs rna NNS cord-349011-kxhpdvri 308 9 based base VBN cord-349011-kxhpdvri 308 10 on on IN cord-349011-kxhpdvri 308 11 their -PRON- PRP$ cord-349011-kxhpdvri 308 12 abundance abundance NN cord-349011-kxhpdvri 308 13 early early RB cord-349011-kxhpdvri 308 14 after after IN cord-349011-kxhpdvri 308 15 infection infection NN cord-349011-kxhpdvri 308 16 Insight insight NN cord-349011-kxhpdvri 308 17 into into IN cord-349011-kxhpdvri 308 18 Influenza influenza NN cord-349011-kxhpdvri 308 19 : : : cord-349011-kxhpdvri 309 1 A a DT cord-349011-kxhpdvri 309 2 Virus Virus NNP cord-349011-kxhpdvri 309 3 Cap Cap NNP cord-349011-kxhpdvri 309 4 - - HYPH cord-349011-kxhpdvri 309 5 Snatching Snatching NNP cord-349011-kxhpdvri 309 6 . . . cord-349011-kxhpdvri 310 1 Viruses Viruses NNP cord-349011-kxhpdvri 310 2 McCormick McCormick NNP cord-349011-kxhpdvri 310 3 , , , cord-349011-kxhpdvri 310 4 C. C. NNP cord-349011-kxhpdvri 310 5 mTORC1 mTORC1 NNP cord-349011-kxhpdvri 310 6 activity activity NN cord-349011-kxhpdvri 310 7 is be VBZ cord-349011-kxhpdvri 310 8 dispensable dispensable JJ cord-349011-kxhpdvri 310 9 for for IN cord-349011-kxhpdvri 310 10 synthesis synthesis NN cord-349011-kxhpdvri 310 11 of of IN cord-349011-kxhpdvri 310 12 KSHV KSHV NNP cord-349011-kxhpdvri 310 13 lytic lytic JJ cord-349011-kxhpdvri 310 14 proteins protein NNS cord-349011-kxhpdvri 310 15 Synthetic synthetic JJ cord-349011-kxhpdvri 310 16 horsepox horsepox NNP cord-349011-kxhpdvri 310 17 viruses virus NNS cord-349011-kxhpdvri 310 18 and and CC cord-349011-kxhpdvri 310 19 the the DT cord-349011-kxhpdvri 310 20 continuing continue VBG cord-349011-kxhpdvri 310 21 debate debate NN cord-349011-kxhpdvri 310 22 about about IN cord-349011-kxhpdvri 310 23 dual dual JJ cord-349011-kxhpdvri 310 24 use use NN cord-349011-kxhpdvri 310 25 research research NN cord-349011-kxhpdvri 311 1 A a DT cord-349011-kxhpdvri 311 2 Pox Pox NNP cord-349011-kxhpdvri 311 3 on on IN cord-349011-kxhpdvri 311 4 Your -PRON- PRP$ cord-349011-kxhpdvri 311 5 Horse horse NN cord-349011-kxhpdvri 311 6 Good good NN cord-349011-kxhpdvri 311 7 Virologists Virologists NNPS cord-349011-kxhpdvri 311 8 Go go VBP cord-349011-kxhpdvri 311 9 to to IN cord-349011-kxhpdvri 311 10 Halifax Halifax NNP cord-349011-kxhpdvri 311 11 Global Global NNP cord-349011-kxhpdvri 311 12 shape shape NN cord-349011-kxhpdvri 311 13 mimicry mimicry NN cord-349011-kxhpdvri 311 14 of of IN cord-349011-kxhpdvri 311 15 tRNA trna NN cord-349011-kxhpdvri 311 16 within within IN cord-349011-kxhpdvri 311 17 a a DT cord-349011-kxhpdvri 311 18 viral viral JJ cord-349011-kxhpdvri 311 19 internal internal JJ cord-349011-kxhpdvri 311 20 ribosome ribosome NN cord-349011-kxhpdvri 311 21 entry entry NN cord-349011-kxhpdvri 311 22 site site NN cord-349011-kxhpdvri 312 1 mediates mediate VBZ cord-349011-kxhpdvri 312 2 translational translational JJ cord-349011-kxhpdvri 312 3 reading reading NN cord-349011-kxhpdvri 312 4 frame frame NN cord-349011-kxhpdvri 312 5 selection selection NN cord-349011-kxhpdvri 312 6 Functional Functional NNP cord-349011-kxhpdvri 312 7 Insights Insights NNPS cord-349011-kxhpdvri 312 8 into into IN cord-349011-kxhpdvri 312 9 the the DT cord-349011-kxhpdvri 312 10 Adjacent Adjacent NNP cord-349011-kxhpdvri 312 11 Stem Stem NNP cord-349011-kxhpdvri 312 12 - - HYPH cord-349011-kxhpdvri 312 13 Loop Loop NNP cord-349011-kxhpdvri 312 14 in in IN cord-349011-kxhpdvri 312 15 Honey Honey NNP cord-349011-kxhpdvri 312 16 Bee Bee NNP cord-349011-kxhpdvri 312 17 Dicistroviruses Dicistroviruses NNP cord-349011-kxhpdvri 312 18 That that WDT cord-349011-kxhpdvri 312 19 Promotes promote VBZ cord-349011-kxhpdvri 312 20 Internal Internal NNP cord-349011-kxhpdvri 312 21 Ribosome Ribosome NNP cord-349011-kxhpdvri 312 22 Entry Entry NNP cord-349011-kxhpdvri 312 23 Site Site NNP cord-349011-kxhpdvri 312 24 - - HYPH cord-349011-kxhpdvri 312 25 Mediated mediate VBN cord-349011-kxhpdvri 312 26 Translation translation NN cord-349011-kxhpdvri 312 27 and and CC cord-349011-kxhpdvri 312 28 Viral viral JJ cord-349011-kxhpdvri 312 29 Infection infection NN cord-349011-kxhpdvri 313 1 IRES ires JJ cord-349011-kxhpdvri 313 2 - - HYPH cord-349011-kxhpdvri 313 3 dependent dependent JJ cord-349011-kxhpdvri 313 4 ribosome ribosome NN cord-349011-kxhpdvri 313 5 repositioning repositioning NN cord-349011-kxhpdvri 313 6 directs direct VBZ cord-349011-kxhpdvri 313 7 translation translation NN cord-349011-kxhpdvri 313 8 of of IN cord-349011-kxhpdvri 313 9 a a DT cord-349011-kxhpdvri 313 10 +1 +1 XX cord-349011-kxhpdvri 313 11 overlapping overlap VBG cord-349011-kxhpdvri 313 12 ORF ORF NNP cord-349011-kxhpdvri 313 13 that that WDT cord-349011-kxhpdvri 313 14 enhances enhance VBZ cord-349011-kxhpdvri 313 15 viral viral JJ cord-349011-kxhpdvri 313 16 infection infection NN cord-349011-kxhpdvri 313 17 Plant plant NN cord-349011-kxhpdvri 313 18 Viral Viral NNP cord-349011-kxhpdvri 313 19 Proteases Proteases NNP cord-349011-kxhpdvri 313 20 : : : cord-349011-kxhpdvri 313 21 Beyond beyond IN cord-349011-kxhpdvri 313 22 the the DT cord-349011-kxhpdvri 313 23 Role role NN cord-349011-kxhpdvri 313 24 of of IN cord-349011-kxhpdvri 313 25 Peptide Peptide NNP cord-349011-kxhpdvri 313 26 Cutters Cutters NNPS cord-349011-kxhpdvri 313 27 . . . cord-349011-kxhpdvri 314 1 Front front JJ cord-349011-kxhpdvri 314 2 Expanding expand VBG cord-349011-kxhpdvri 314 3 Repertoire repertoire NN cord-349011-kxhpdvri 314 4 of of IN cord-349011-kxhpdvri 314 5 Plant Plant NNP cord-349011-kxhpdvri 314 6 Positive Positive NNP cord-349011-kxhpdvri 314 7 - - HYPH cord-349011-kxhpdvri 314 8 Strand strand NN cord-349011-kxhpdvri 314 9 RNA RNA NNP cord-349011-kxhpdvri 314 10 Virus Virus NNP cord-349011-kxhpdvri 314 11 Proteases Proteases NNP cord-349011-kxhpdvri 314 12 Identification Identification NNP cord-349011-kxhpdvri 314 13 of of IN cord-349011-kxhpdvri 314 14 Cleavage Cleavage NNP cord-349011-kxhpdvri 314 15 Sites Sites NNPS cord-349011-kxhpdvri 314 16 Recognized recognize VBN cord-349011-kxhpdvri 314 17 by by IN cord-349011-kxhpdvri 314 18 the the DT cord-349011-kxhpdvri 314 19 3C 3c NN cord-349011-kxhpdvri 314 20 - - HYPH cord-349011-kxhpdvri 314 21 Like Like NNP cord-349011-kxhpdvri 314 22 Cysteine Cysteine NNP cord-349011-kxhpdvri 314 23 Protease Protease NNP cord-349011-kxhpdvri 314 24 within within IN cord-349011-kxhpdvri 314 25 the the DT cord-349011-kxhpdvri 314 26 Two two CD cord-349011-kxhpdvri 314 27 Polyproteins Polyproteins NNPS cord-349011-kxhpdvri 314 28 of of IN cord-349011-kxhpdvri 314 29 Strawberry Strawberry NNP cord-349011-kxhpdvri 314 30 Mottle Mottle NNP cord-349011-kxhpdvri 314 31 Virus Virus NNP cord-349011-kxhpdvri 314 32 Strawberry Strawberry NNP cord-349011-kxhpdvri 314 33 mottle mottle NN cord-349011-kxhpdvri 314 34 virus virus NN cord-349011-kxhpdvri 314 35 ( ( -LRB- cord-349011-kxhpdvri 314 36 family family NN cord-349011-kxhpdvri 314 37 Secoviridae Secoviridae NNP cord-349011-kxhpdvri 314 38 , , , cord-349011-kxhpdvri 314 39 order order NN cord-349011-kxhpdvri 314 40 Picornavirales Picornavirales NNP cord-349011-kxhpdvri 314 41 ) ) -RRB- cord-349011-kxhpdvri 314 42 encodes encode VBZ cord-349011-kxhpdvri 314 43 a a DT cord-349011-kxhpdvri 314 44 novel novel JJ cord-349011-kxhpdvri 314 45 glutamic glutamic NN cord-349011-kxhpdvri 314 46 protease protease NN cord-349011-kxhpdvri 314 47 to to TO cord-349011-kxhpdvri 314 48 process process VB cord-349011-kxhpdvri 314 49 the the DT cord-349011-kxhpdvri 314 50 RNA2 RNA2 NNP cord-349011-kxhpdvri 314 51 polyprotein polyprotein NN cord-349011-kxhpdvri 314 52 at at IN cord-349011-kxhpdvri 314 53 two two CD cord-349011-kxhpdvri 314 54 cleavage cleavage NN cord-349011-kxhpdvri 314 55 sites site NNS cord-349011-kxhpdvri 314 56 Scavengers scavenger NNS cord-349011-kxhpdvri 314 57 for for IN cord-349011-kxhpdvri 314 58 bacteria bacteria NNS cord-349011-kxhpdvri 314 59 : : : cord-349011-kxhpdvri 315 1 Rainbow rainbow NN cord-349011-kxhpdvri 315 2 trout trout NNS cord-349011-kxhpdvri 315 3 have have VBP cord-349011-kxhpdvri 315 4 two two CD cord-349011-kxhpdvri 315 5 functional functional JJ cord-349011-kxhpdvri 315 6 variants variant NNS cord-349011-kxhpdvri 315 7 of of IN cord-349011-kxhpdvri 315 8 MARCO MARCO NNP cord-349011-kxhpdvri 315 9 that that WDT cord-349011-kxhpdvri 315 10 bind bind VBP cord-349011-kxhpdvri 315 11 to to IN cord-349011-kxhpdvri 315 12 gram gram NN cord-349011-kxhpdvri 315 13 - - HYPH cord-349011-kxhpdvri 315 14 negative negative JJ cord-349011-kxhpdvri 315 15 and and CC cord-349011-kxhpdvri 316 1 -positive -positive JJ cord-349011-kxhpdvri 316 2 bacteria bacteria NNS cord-349011-kxhpdvri 317 1 In in IN cord-349011-kxhpdvri 317 2 vitro vitro FW cord-349011-kxhpdvri 317 3 transcribed transcribe VBN cord-349011-kxhpdvri 317 4 dsRNA dsrna NN cord-349011-kxhpdvri 317 5 limits limit NNS cord-349011-kxhpdvri 317 6 viral viral JJ cord-349011-kxhpdvri 317 7 hemorrhagic hemorrhagic JJ cord-349011-kxhpdvri 317 8 septicemia septicemia NN cord-349011-kxhpdvri 317 9 virus virus NN cord-349011-kxhpdvri 317 10 ( ( -LRB- cord-349011-kxhpdvri 317 11 VHSV)-IVb vhsv)-ivb CD cord-349011-kxhpdvri 317 12 infection infection NN cord-349011-kxhpdvri 317 13 in in IN cord-349011-kxhpdvri 317 14 a a DT cord-349011-kxhpdvri 317 15 novel novel JJ cord-349011-kxhpdvri 317 16 fathead fathead NN cord-349011-kxhpdvri 317 17 minnow minnow NN cord-349011-kxhpdvri 317 18 ( ( -LRB- cord-349011-kxhpdvri 317 19 Pimephales Pimephales NNP cord-349011-kxhpdvri 317 20 promelas promelas NNP cord-349011-kxhpdvri 317 21 ) ) -RRB- cord-349011-kxhpdvri 318 1 skin skin NN cord-349011-kxhpdvri 318 2 cell cell NN cord-349011-kxhpdvri 318 3 line line NN cord-349011-kxhpdvri 318 4 Class Class NNP cord-349011-kxhpdvri 318 5 - - HYPH cord-349011-kxhpdvri 318 6 A a DT cord-349011-kxhpdvri 318 7 scavenger scavenger NN cord-349011-kxhpdvri 318 8 receptor receptor NN cord-349011-kxhpdvri 318 9 function function NN cord-349011-kxhpdvri 318 10 and and CC cord-349011-kxhpdvri 318 11 expression expression NN cord-349011-kxhpdvri 318 12 in in IN cord-349011-kxhpdvri 318 13 the the DT cord-349011-kxhpdvri 318 14 rainbow rainbow NN cord-349011-kxhpdvri 318 15 trout trout NN cord-349011-kxhpdvri 318 16 ( ( -LRB- cord-349011-kxhpdvri 319 1 Oncorhynchus Oncorhynchus NNP cord-349011-kxhpdvri 319 2 mykiss mykiss NN cord-349011-kxhpdvri 319 3 ) ) -RRB- cord-349011-kxhpdvri 319 4 epithelial epithelial JJ cord-349011-kxhpdvri 319 5 cell cell NN cord-349011-kxhpdvri 319 6 lines line NNS cord-349011-kxhpdvri 319 7 RTgutGC RTgutGC NNS cord-349011-kxhpdvri 319 8 and and CC cord-349011-kxhpdvri 319 9 RTgill RTgill NNP cord-349011-kxhpdvri 319 10 - - HYPH cord-349011-kxhpdvri 319 11 W1 W1 NNP cord-349011-kxhpdvri 319 12 Class Class NNP cord-349011-kxhpdvri 319 13 A a DT cord-349011-kxhpdvri 319 14 scavenger scavenger NN cord-349011-kxhpdvri 319 15 receptors receptor NNS cord-349011-kxhpdvri 319 16 mediate mediate VBP cord-349011-kxhpdvri 319 17 extracellular extracellular JJ cord-349011-kxhpdvri 319 18 dsRNA dsrna NN cord-349011-kxhpdvri 319 19 sensing sensing NN cord-349011-kxhpdvri 319 20 , , , cord-349011-kxhpdvri 319 21 leading lead VBG cord-349011-kxhpdvri 319 22 to to IN cord-349011-kxhpdvri 319 23 downstream downstream JJ cord-349011-kxhpdvri 319 24 antiviral antiviral JJ cord-349011-kxhpdvri 319 25 gene gene NN cord-349011-kxhpdvri 319 26 expression expression NN cord-349011-kxhpdvri 319 27 in in IN cord-349011-kxhpdvri 319 28 a a DT cord-349011-kxhpdvri 319 29 novel novel JJ cord-349011-kxhpdvri 319 30 American american JJ cord-349011-kxhpdvri 319 31 toad toad NN cord-349011-kxhpdvri 319 32 cell cell NN cord-349011-kxhpdvri 319 33 line line NN cord-349011-kxhpdvri 319 34 CHSE-214 chse-214 NN cord-349011-kxhpdvri 319 35 : : : cord-349011-kxhpdvri 320 1 A a DT cord-349011-kxhpdvri 320 2 model model NN cord-349011-kxhpdvri 320 3 for for IN cord-349011-kxhpdvri 320 4 studying study VBG cord-349011-kxhpdvri 320 5 extracellular extracellular JJ cord-349011-kxhpdvri 320 6 dsRNA dsrna NN cord-349011-kxhpdvri 320 7 sensing sensing NN cord-349011-kxhpdvri 320 8 in in IN cord-349011-kxhpdvri 320 9 vitro vitro FW cord-349011-kxhpdvri 320 10 Duck Duck NNP cord-349011-kxhpdvri 320 11 innate innate VBP cord-349011-kxhpdvri 320 12 immune immune JJ cord-349011-kxhpdvri 320 13 responses response NNS cord-349011-kxhpdvri 320 14 to to IN cord-349011-kxhpdvri 320 15 high high JJ cord-349011-kxhpdvri 320 16 and and CC cord-349011-kxhpdvri 320 17 low low JJ cord-349011-kxhpdvri 320 18 pathogenicity pathogenicity NN cord-349011-kxhpdvri 320 19 H5 h5 NN cord-349011-kxhpdvri 320 20 avian avian JJ cord-349011-kxhpdvri 320 21 influenza influenza NN cord-349011-kxhpdvri 320 22 viruses virus NNS cord-349011-kxhpdvri 321 1 We -PRON- PRP cord-349011-kxhpdvri 321 2 are be VBP cord-349011-kxhpdvri 321 3 grateful grateful JJ cord-349011-kxhpdvri 321 4 to to IN cord-349011-kxhpdvri 321 5 our -PRON- PRP$ cord-349011-kxhpdvri 321 6 colleagues colleague NNS cord-349011-kxhpdvri 321 7 who who WP cord-349011-kxhpdvri 321 8 allowed allow VBD cord-349011-kxhpdvri 321 9 us -PRON- PRP cord-349011-kxhpdvri 321 10 to to TO cord-349011-kxhpdvri 321 11 communicate communicate VB cord-349011-kxhpdvri 321 12 elements element NNS cord-349011-kxhpdvri 321 13 of of IN cord-349011-kxhpdvri 321 14 their -PRON- PRP$ cord-349011-kxhpdvri 321 15 Acknowledgments acknowledgment NNS cord-349011-kxhpdvri 321 16 : : : cord-349011-kxhpdvri 321 17 We -PRON- PRP cord-349011-kxhpdvri 321 18 are be VBP cord-349011-kxhpdvri 321 19 grateful grateful JJ cord-349011-kxhpdvri 321 20 to to IN cord-349011-kxhpdvri 321 21 our -PRON- PRP$ cord-349011-kxhpdvri 321 22 colleagues colleague NNS cord-349011-kxhpdvri 321 23 who who WP cord-349011-kxhpdvri 321 24 allowed allow VBD cord-349011-kxhpdvri 321 25 us -PRON- PRP cord-349011-kxhpdvri 321 26 to to TO cord-349011-kxhpdvri 321 27 communicate communicate VB cord-349011-kxhpdvri 321 28 elements element NNS cord-349011-kxhpdvri 321 29 of of IN cord-349011-kxhpdvri 321 30 their -PRON- PRP$ cord-349011-kxhpdvri 321 31 workshop workshop NN cord-349011-kxhpdvri 321 32 presentations presentation NNS cord-349011-kxhpdvri 321 33 in in IN cord-349011-kxhpdvri 321 34 this this DT cord-349011-kxhpdvri 321 35 report report NN cord-349011-kxhpdvri 321 36 . . . cord-349011-kxhpdvri 322 1 We -PRON- PRP cord-349011-kxhpdvri 322 2 thank thank VBP cord-349011-kxhpdvri 322 3 members member NNS cord-349011-kxhpdvri 322 4 of of IN cord-349011-kxhpdvri 322 5 the the DT cord-349011-kxhpdvri 322 6 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 322 7 Scientific Scientific NNP cord-349011-kxhpdvri 322 8 Advisory Advisory NNP cord-349011-kxhpdvri 322 9 Committee Committee NNP cord-349011-kxhpdvri 322 10 ( ( -LRB- cord-349011-kxhpdvri 322 11 Drs Drs NNP cord-349011-kxhpdvri 322 12 . . . cord-349011-kxhpdvri 323 1 Marceline Marceline NNP cord-349011-kxhpdvri 323 2 Côté Côté NNP cord-349011-kxhpdvri 323 3 , , , cord-349011-kxhpdvri 323 4 Darryl Darryl NNP cord-349011-kxhpdvri 323 5 Falzarano Falzarano NNP cord-349011-kxhpdvri 323 6 , , , cord-349011-kxhpdvri 323 7 Matthias Matthias NNP cord-349011-kxhpdvri 323 8 Götte Götte NNP cord-349011-kxhpdvri 323 9 , , , cord-349011-kxhpdvri 323 10 Karen Karen NNP cord-349011-kxhpdvri 323 11 Maxwell Maxwell NNP cord-349011-kxhpdvri 323 12 , , , cord-349011-kxhpdvri 323 13 Nelly Nelly NNP cord-349011-kxhpdvri 323 14 Pante Pante NNP cord-349011-kxhpdvri 323 15 and and CC cord-349011-kxhpdvri 323 16 Andrew Andrew NNP cord-349011-kxhpdvri 323 17 White White NNP cord-349011-kxhpdvri 323 18 ) ) -RRB- cord-349011-kxhpdvri 323 19 who who WP cord-349011-kxhpdvri 323 20 planned plan VBD cord-349011-kxhpdvri 323 21 scientific scientific JJ cord-349011-kxhpdvri 323 22 sessions session NNS cord-349011-kxhpdvri 323 23 and and CC cord-349011-kxhpdvri 323 24 reviewed review VBD cord-349011-kxhpdvri 323 25 travel travel NN cord-349011-kxhpdvri 323 26 award award NN cord-349011-kxhpdvri 323 27 applications application NNS cord-349011-kxhpdvri 323 28 . . . cord-349011-kxhpdvri 324 1 We -PRON- PRP cord-349011-kxhpdvri 324 2 thank thank VBP cord-349011-kxhpdvri 324 3 the the DT cord-349011-kxhpdvri 324 4 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 324 5 Local Local NNP cord-349011-kxhpdvri 324 6 Organizing Organizing NNP cord-349011-kxhpdvri 324 7 Committee Committee NNP cord-349011-kxhpdvri 324 8 ( ( -LRB- cord-349011-kxhpdvri 324 9 Drs Drs NNP cord-349011-kxhpdvri 324 10 . . . cord-349011-kxhpdvri 325 1 Lisa Lisa NNP cord-349011-kxhpdvri 325 2 Barrett Barrett NNP cord-349011-kxhpdvri 325 3 , , , cord-349011-kxhpdvri 325 4 Jeanette Jeanette NNP cord-349011-kxhpdvri 325 5 Boudreau Boudreau NNP cord-349011-kxhpdvri 325 6 , , , cord-349011-kxhpdvri 325 7 Jenn Jenn NNP cord-349011-kxhpdvri 325 8 Corcoran Corcoran NNP cord-349011-kxhpdvri 325 9 , , , cord-349011-kxhpdvri 325 10 Roy Roy NNP cord-349011-kxhpdvri 325 11 Duncan Duncan NNP cord-349011-kxhpdvri 325 12 , , , cord-349011-kxhpdvri 325 13 May May NNP cord-349011-kxhpdvri 325 14 El El NNP cord-349011-kxhpdvri 325 15 - - HYPH cord-349011-kxhpdvri 325 16 Sherif Sherif NNP cord-349011-kxhpdvri 325 17 , , , cord-349011-kxhpdvri 325 18 Todd Todd NNP cord-349011-kxhpdvri 325 19 Hatchette Hatchette NNP cord-349011-kxhpdvri 325 20 , , , cord-349011-kxhpdvri 325 21 Alyson Alyson NNP cord-349011-kxhpdvri 325 22 Kelvin Kelvin NNP cord-349011-kxhpdvri 325 23 , , , cord-349011-kxhpdvri 325 24 Denys Denys NNP cord-349011-kxhpdvri 325 25 Khaperskyy Khaperskyy NNP cord-349011-kxhpdvri 325 26 , , , cord-349011-kxhpdvri 325 27 Jason Jason NNP cord-349011-kxhpdvri 325 28 LeBlanc LeBlanc NNP cord-349011-kxhpdvri 325 29 , , , cord-349011-kxhpdvri 325 30 Chris Chris NNP cord-349011-kxhpdvri 325 31 Richardson Richardson NNP cord-349011-kxhpdvri 325 32 and and CC cord-349011-kxhpdvri 325 33 Rod Rod NNP cord-349011-kxhpdvri 325 34 Russell Russell NNP cord-349011-kxhpdvri 325 35 ) ) -RRB- cord-349011-kxhpdvri 325 36 who who WP cord-349011-kxhpdvri 325 37 raised raise VBD cord-349011-kxhpdvri 325 38 funds fund NNS cord-349011-kxhpdvri 325 39 and and CC cord-349011-kxhpdvri 325 40 planned planned JJ cord-349011-kxhpdvri 325 41 meeting meeting NN cord-349011-kxhpdvri 325 42 logistics logistic NNS cord-349011-kxhpdvri 325 43 . . . cord-349011-kxhpdvri 326 1 We -PRON- PRP cord-349011-kxhpdvri 326 2 thank thank VBP cord-349011-kxhpdvri 326 3 the the DT cord-349011-kxhpdvri 326 4 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 326 5 Student Student NNP cord-349011-kxhpdvri 326 6 Committee Committee NNP cord-349011-kxhpdvri 326 7 , , , cord-349011-kxhpdvri 326 8 led lead VBN cord-349011-kxhpdvri 326 9 by by IN cord-349011-kxhpdvri 326 10 Dr. Dr. NNP cord-349011-kxhpdvri 326 11 Denys Denys NNP cord-349011-kxhpdvri 326 12 Khaperskyy Khaperskyy NNP cord-349011-kxhpdvri 326 13 and and CC cord-349011-kxhpdvri 326 14 including include VBG cord-349011-kxhpdvri 326 15 Quinelle Quinelle NNP cord-349011-kxhpdvri 326 16 Boudreau Boudreau NNP cord-349011-kxhpdvri 326 17 , , , cord-349011-kxhpdvri 326 18 Katrina Katrina NNP cord-349011-kxhpdvri 326 19 Bouzanis Bouzanis NNP cord-349011-kxhpdvri 326 20 , , , cord-349011-kxhpdvri 326 21 Beth Beth NNP cord-349011-kxhpdvri 326 22 Castle Castle NNP cord-349011-kxhpdvri 326 23 , , , cord-349011-kxhpdvri 326 24 Becca Becca NNP cord-349011-kxhpdvri 326 25 Chilvers Chilvers NNPS cord-349011-kxhpdvri 326 26 , , , cord-349011-kxhpdvri 326 27 Brett Brett NNP cord-349011-kxhpdvri 326 28 Duguay Duguay NNP cord-349011-kxhpdvri 326 29 , , , cord-349011-kxhpdvri 326 30 Lucas Lucas NNP cord-349011-kxhpdvri 326 31 Jarche Jarche NNP cord-349011-kxhpdvri 326 32 , , , cord-349011-kxhpdvri 326 33 Mariel Mariel NNP cord-349011-kxhpdvri 326 34 Kleer Kleer NNP cord-349011-kxhpdvri 326 35 , , , cord-349011-kxhpdvri 326 36 Grant Grant NNP cord-349011-kxhpdvri 326 37 MacNeil MacNeil NNP cord-349011-kxhpdvri 326 38 , , , cord-349011-kxhpdvri 326 39 Andrea Andrea NNP cord-349011-kxhpdvri 326 40 Monjo Monjo NNP cord-349011-kxhpdvri 326 41 , , , cord-349011-kxhpdvri 326 42 Rory Rory NNP cord-349011-kxhpdvri 326 43 Mulloy Mulloy NNP cord-349011-kxhpdvri 326 44 , , , cord-349011-kxhpdvri 326 45 Jacob Jacob NNP cord-349011-kxhpdvri 326 46 Nearing Nearing NNP cord-349011-kxhpdvri 326 47 , , , cord-349011-kxhpdvri 326 48 Carolyn Carolyn NNP cord-349011-kxhpdvri 326 49 Robinson Robinson NNP cord-349011-kxhpdvri 326 50 , , , cord-349011-kxhpdvri 326 51 Eric Eric NNP cord-349011-kxhpdvri 326 52 Pringle Pringle NNP cord-349011-kxhpdvri 326 53 , , , cord-349011-kxhpdvri 326 54 Jacob Jacob NNP cord-349011-kxhpdvri 326 55 Sicheri Sicheri NNP cord-349011-kxhpdvri 326 56 , , , cord-349011-kxhpdvri 326 57 Gill Gill NNP cord-349011-kxhpdvri 326 58 Singh Singh NNP cord-349011-kxhpdvri 326 59 , , , cord-349011-kxhpdvri 326 60 Patrick Patrick NNP cord-349011-kxhpdvri 326 61 Slaine Slaine NNP cord-349011-kxhpdvri 326 62 , , , cord-349011-kxhpdvri 326 63 Iona Iona NNP cord-349011-kxhpdvri 326 64 Stylianides Stylianides NNP cord-349011-kxhpdvri 326 65 and and CC cord-349011-kxhpdvri 326 66 Mackenzie Mackenzie NNP cord-349011-kxhpdvri 326 67 Thornbury Thornbury NNP cord-349011-kxhpdvri 326 68 , , , cord-349011-kxhpdvri 326 69 who who WP cord-349011-kxhpdvri 326 70 provided provide VBD cord-349011-kxhpdvri 326 71 essential essential JJ cord-349011-kxhpdvri 326 72 on on IN cord-349011-kxhpdvri 326 73 - - HYPH cord-349011-kxhpdvri 326 74 the the DT cord-349011-kxhpdvri 326 75 - - HYPH cord-349011-kxhpdvri 326 76 ground ground NN cord-349011-kxhpdvri 326 77 logistical logistical JJ cord-349011-kxhpdvri 326 78 support support NN cord-349011-kxhpdvri 326 79 for for IN cord-349011-kxhpdvri 326 80 the the DT cord-349011-kxhpdvri 326 81 symposium symposium NN cord-349011-kxhpdvri 326 82 . . . cord-349011-kxhpdvri 327 1 We -PRON- PRP cord-349011-kxhpdvri 327 2 thank thank VBP cord-349011-kxhpdvri 327 3 Emma Emma NNP cord-349011-kxhpdvri 327 4 Finlayson Finlayson NNP cord-349011-kxhpdvri 327 5 - - HYPH cord-349011-kxhpdvri 327 6 Trick Trick NNP cord-349011-kxhpdvri 327 7 for for IN cord-349011-kxhpdvri 327 8 organizing organize VBG cord-349011-kxhpdvri 327 9 the the DT cord-349011-kxhpdvri 327 10 Soapbox Soapbox NNP cord-349011-kxhpdvri 327 11 Science Science NNP cord-349011-kxhpdvri 327 12 preview preview NN cord-349011-kxhpdvri 327 13 and and CC cord-349011-kxhpdvri 327 14 launch launch VB cord-349011-kxhpdvri 327 15 events event NNS cord-349011-kxhpdvri 327 16 . . . cord-349011-kxhpdvri 328 1 We -PRON- PRP cord-349011-kxhpdvri 328 2 thank thank VBP cord-349011-kxhpdvri 328 3 Drs Drs NNP cord-349011-kxhpdvri 328 4 . . . cord-349011-kxhpdvri 329 1 Maya Maya NNP cord-349011-kxhpdvri 329 2 Shmulevitz Shmulevitz NNP cord-349011-kxhpdvri 329 3 , , , cord-349011-kxhpdvri 329 4 Alyson Alyson NNP cord-349011-kxhpdvri 329 5 Kelvin Kelvin NNP cord-349011-kxhpdvri 329 6 and and CC cord-349011-kxhpdvri 329 7 Sarah Sarah NNP cord-349011-kxhpdvri 329 8 Wells Wells NNP cord-349011-kxhpdvri 329 9 and and CC cord-349011-kxhpdvri 329 10 PhD phd NN cord-349011-kxhpdvri 329 11 student student NN cord-349011-kxhpdvri 329 12 Krysta Krysta NNP cord-349011-kxhpdvri 329 13 Coyle Coyle NNP cord-349011-kxhpdvri 329 14 for for IN cord-349011-kxhpdvri 329 15 their -PRON- PRP$ cord-349011-kxhpdvri 329 16 Soapbox Soapbox NNP cord-349011-kxhpdvri 329 17 Science Science NNP cord-349011-kxhpdvri 329 18 presentations presentation NNS cord-349011-kxhpdvri 329 19 . . . cord-349011-kxhpdvri 330 1 We -PRON- PRP cord-349011-kxhpdvri 330 2 thank thank VBP cord-349011-kxhpdvri 330 3 Quentin Quentin NNP cord-349011-kxhpdvri 330 4 Osseman Osseman NNP cord-349011-kxhpdvri 330 5 , , , cord-349011-kxhpdvri 330 6 Gillian Gillian NNP cord-349011-kxhpdvri 330 7 Singh Singh NNP cord-349011-kxhpdvri 330 8 and and CC cord-349011-kxhpdvri 330 9 Denys Denys NNP cord-349011-kxhpdvri 330 10 Khaperskyy Khaperskyy NNP cord-349011-kxhpdvri 330 11 for for IN cord-349011-kxhpdvri 330 12 photography photography NN cord-349011-kxhpdvri 330 13 . . . cord-349011-kxhpdvri 331 1 We -PRON- PRP cord-349011-kxhpdvri 331 2 thank thank VBP cord-349011-kxhpdvri 331 3 Manon Manon NNP cord-349011-kxhpdvri 331 4 Livernois Livernois NNP cord-349011-kxhpdvri 331 5 ( ( -LRB- cord-349011-kxhpdvri 331 6 CRCHUM CRCHUM NNP cord-349011-kxhpdvri 331 7 ) ) -RRB- cord-349011-kxhpdvri 331 8 for for IN cord-349011-kxhpdvri 331 9 administrative administrative JJ cord-349011-kxhpdvri 331 10 assistance assistance NN cord-349011-kxhpdvri 331 11 . . . cord-349011-kxhpdvri 332 1 We -PRON- PRP cord-349011-kxhpdvri 332 2 thank thank VBP cord-349011-kxhpdvri 332 3 Lucas Lucas NNP cord-349011-kxhpdvri 332 4 Jarche Jarche NNP cord-349011-kxhpdvri 332 5 for for IN cord-349011-kxhpdvri 332 6 CSV csv NN cord-349011-kxhpdvri 332 7 logo logo NN cord-349011-kxhpdvri 332 8 artwork artwork NN cord-349011-kxhpdvri 332 9 . . . cord-349011-kxhpdvri 333 1 CSV2018 CSV2018 NNP cord-349011-kxhpdvri 333 2 was be VBD cord-349011-kxhpdvri 333 3 supported support VBN cord-349011-kxhpdvri 333 4 by by IN cord-349011-kxhpdvri 333 5 grants grant NNS cord-349011-kxhpdvri 333 6 from from IN cord-349011-kxhpdvri 333 7 the the DT cord-349011-kxhpdvri 333 8 Canadian Canadian NNP cord-349011-kxhpdvri 333 9 Institutes Institutes NNPS cord-349011-kxhpdvri 333 10 of of IN cord-349011-kxhpdvri 333 11 Health Health NNP cord-349011-kxhpdvri 333 12 Research Research NNP cord-349011-kxhpdvri 333 13 ( ( -LRB- cord-349011-kxhpdvri 333 14 CIHR CIHR NNP cord-349011-kxhpdvri 333 15 - - HYPH cord-349011-kxhpdvri 333 16 MPL-158413 MPL-158413 NNP cord-349011-kxhpdvri 333 17 ) ) -RRB- cord-349011-kxhpdvri 333 18 and and CC cord-349011-kxhpdvri 333 19 the the DT cord-349011-kxhpdvri 333 20 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 333 21 Medical Medical NNP cord-349011-kxhpdvri 333 22 Research Research NNP cord-349011-kxhpdvri 333 23 Foundation Foundation NNP cord-349011-kxhpdvri 333 24 . . . cord-349011-kxhpdvri 334 1 Additional additional JJ cord-349011-kxhpdvri 334 2 support support NN cord-349011-kxhpdvri 334 3 was be VBD cord-349011-kxhpdvri 334 4 provided provide VBN cord-349011-kxhpdvri 334 5 by by IN cord-349011-kxhpdvri 334 6 Dalhousie Dalhousie NNP cord-349011-kxhpdvri 334 7 University University NNP cord-349011-kxhpdvri 334 8 , , , cord-349011-kxhpdvri 334 9 the the DT cord-349011-kxhpdvri 334 10 Li Li NNP cord-349011-kxhpdvri 334 11 Ka Ka NNP cord-349011-kxhpdvri 334 12 Shing Shing NNP cord-349011-kxhpdvri 334 13 Institute Institute NNP cord-349011-kxhpdvri 334 14 of of IN cord-349011-kxhpdvri 334 15 Virology Virology NNP cord-349011-kxhpdvri 334 16 , , , cord-349011-kxhpdvri 334 17 VIDO VIDO NNP cord-349011-kxhpdvri 334 18 - - HYPH cord-349011-kxhpdvri 334 19 InterVac InterVac NNP cord-349011-kxhpdvri 334 20 , , , cord-349011-kxhpdvri 334 21 PLoS PLoS NNP cord-349011-kxhpdvri 334 22 Pathogens Pathogens NNPS cord-349011-kxhpdvri 334 23 , , , cord-349011-kxhpdvri 334 24 PLoS PLoS NNP cord-349011-kxhpdvri 334 25 ONE one CD cord-349011-kxhpdvri 334 26 , , , cord-349011-kxhpdvri 334 27 Viruses Viruses NNPS cord-349011-kxhpdvri 334 28 , , , cord-349011-kxhpdvri 334 29 Canadian Canadian NNP cord-349011-kxhpdvri 334 30 Journal Journal NNP cord-349011-kxhpdvri 334 31 of of IN cord-349011-kxhpdvri 334 32 Microbiology Microbiology NNP cord-349011-kxhpdvri 334 33 , , , cord-349011-kxhpdvri 334 34 IMV IMV NNP cord-349011-kxhpdvri 334 35 ™ ™ NN cord-349011-kxhpdvri 334 36 , , , cord-349011-kxhpdvri 334 37 Zeiss Zeiss NNP cord-349011-kxhpdvri 334 38 , , , cord-349011-kxhpdvri 334 39 Nikon Nikon NNP cord-349011-kxhpdvri 334 40 and and CC cord-349011-kxhpdvri 334 41 Sanofi Sanofi NNP cord-349011-kxhpdvri 334 42 . . . cord-349011-kxhpdvri 335 1 The the DT cord-349011-kxhpdvri 335 2 authors author NNS cord-349011-kxhpdvri 335 3 declare declare VBP cord-349011-kxhpdvri 335 4 no no DT cord-349011-kxhpdvri 335 5 conflict conflict NN cord-349011-kxhpdvri 335 6 of of IN cord-349011-kxhpdvri 335 7 interest interest NN cord-349011-kxhpdvri 335 8 . . .