id	sid	tid	token	lemma	pos
cord-350836-1enteev7	1	1	key	key	JJ
cord-350836-1enteev7	1	2	:	:	:
cord-350836-1enteev7	1	3	cord-350836	cord-350836	NN
cord-350836-1enteev7	1	4	-	-	HYPH
cord-350836-1enteev7	1	5	1enteev7	1enteev7	CD
cord-350836-1enteev7	1	6	authors	author	NNS
cord-350836-1enteev7	1	7	:	:	:
cord-350836-1enteev7	1	8	Brisse	Brisse	NNP
cord-350836-1enteev7	1	9	,	,	,
cord-350836-1enteev7	1	10	Morgan	Morgan	NNP
cord-350836-1enteev7	1	11	;	;	:
cord-350836-1enteev7	1	12	Ly	Ly	NNP
cord-350836-1enteev7	1	13	,	,	,
cord-350836-1enteev7	1	14	Hinh	Hinh	NNP
cord-350836-1enteev7	1	15	title	title	NN
cord-350836-1enteev7	1	16	:	:	:
cord-350836-1enteev7	1	17	Comparative	Comparative	NNP
cord-350836-1enteev7	1	18	Structure	Structure	NNP
cord-350836-1enteev7	1	19	and	and	CC
cord-350836-1enteev7	1	20	Function	Function	NNP
cord-350836-1enteev7	1	21	Analysis	Analysis	NNP
cord-350836-1enteev7	1	22	of	of	IN
cord-350836-1enteev7	1	23	the	the	DT
cord-350836-1enteev7	1	24	RIG	rig	NN
cord-350836-1enteev7	1	25	-	-	HYPH
cord-350836-1enteev7	1	26	I	I	NNP
cord-350836-1enteev7	1	27	-	-	HYPH
cord-350836-1enteev7	1	28	Like	like	JJ
cord-350836-1enteev7	1	29	Receptors	receptor	NNS
cord-350836-1enteev7	1	30	:	:	:
cord-350836-1enteev7	1	31	RIG	rig	NN
cord-350836-1enteev7	1	32	-	-	:
cord-350836-1enteev7	1	33	I	I	NNP
cord-350836-1enteev7	1	34	and	and	CC
cord-350836-1enteev7	1	35	MDA5	mda5	JJ
cord-350836-1enteev7	1	36	date	date	NN
cord-350836-1enteev7	1	37	:	:	:
cord-350836-1enteev7	1	38	2019	2019	CD
cord-350836-1enteev7	1	39	-	-	HYPH
cord-350836-1enteev7	1	40	07	07	CD
cord-350836-1enteev7	1	41	-	-	SYM
cord-350836-1enteev7	1	42	17	17	CD
cord-350836-1enteev7	1	43	journal	journal	NN
cord-350836-1enteev7	1	44	:	:	:
cord-350836-1enteev7	2	1	Front	Front	NNP
cord-350836-1enteev7	2	2	Immunol	Immunol	NNP
cord-350836-1enteev7	2	3	DOI	doi	NN
cord-350836-1enteev7	2	4	:	:	:
cord-350836-1enteev7	3	1	10.3389	10.3389	CD
cord-350836-1enteev7	3	2	/	/	SYM
cord-350836-1enteev7	3	3	fimmu.2019.01586	fimmu.2019.01586	NNS
cord-350836-1enteev7	3	4	sha	sha	NNP
cord-350836-1enteev7	3	5	:	:	:
cord-350836-1enteev7	4	1	401ebad7d8d7416f0bf26c8192eb57bfb61f378b	401ebad7d8d7416f0bf26c8192eb57bfb61f378b	CD
cord-350836-1enteev7	4	2	doc_id	doc_id	CD
cord-350836-1enteev7	4	3	:	:	:
cord-350836-1enteev7	4	4	350836	350836	CD
cord-350836-1enteev7	4	5	cord_uid	cord_uid	NN
cord-350836-1enteev7	4	6	:	:	:
cord-350836-1enteev7	5	1	1enteev7	1enteev7	CD
cord-350836-1enteev7	5	2	RIG	rig	NN
cord-350836-1enteev7	5	3	-	-	:
cord-350836-1enteev7	5	4	I	i	NN
cord-350836-1enteev7	6	1	(	(	-LRB-
cord-350836-1enteev7	6	2	Retinoic	retinoic	JJ
cord-350836-1enteev7	6	3	acid	acid	NN
cord-350836-1enteev7	6	4	-	-	HYPH
cord-350836-1enteev7	6	5	inducible	inducible	JJ
cord-350836-1enteev7	6	6	gene	gene	NN
cord-350836-1enteev7	6	7	I	i	NN
cord-350836-1enteev7	6	8	)	)	-RRB-
cord-350836-1enteev7	6	9	and	and	CC
cord-350836-1enteev7	6	10	MDA5	MDA5	NNP
cord-350836-1enteev7	7	1	(	(	-LRB-
cord-350836-1enteev7	7	2	Melanoma	Melanoma	NNP
cord-350836-1enteev7	7	3	Differentiation	differentiation	NN
cord-350836-1enteev7	7	4	-	-	HYPH
cord-350836-1enteev7	7	5	Associated	Associated	NNP
cord-350836-1enteev7	7	6	protein	protein	NN
cord-350836-1enteev7	7	7	5	5	CD
cord-350836-1enteev7	7	8	)	)	-RRB-
cord-350836-1enteev7	7	9	,	,	,
cord-350836-1enteev7	7	10	collectively	collectively	RB
cord-350836-1enteev7	7	11	known	know	VBN
cord-350836-1enteev7	7	12	as	as	IN
cord-350836-1enteev7	7	13	the	the	DT
cord-350836-1enteev7	7	14	RIG	rig	NN
cord-350836-1enteev7	7	15	-	-	HYPH
cord-350836-1enteev7	7	16	I	i	NN
cord-350836-1enteev7	7	17	-	-	HYPH
cord-350836-1enteev7	7	18	like	like	JJ
cord-350836-1enteev7	7	19	receptors	receptor	NNS
cord-350836-1enteev7	7	20	(	(	-LRB-
cord-350836-1enteev7	7	21	RLRs	RLRs	NNP
cord-350836-1enteev7	7	22	)	)	-RRB-
cord-350836-1enteev7	7	23	,	,	,
cord-350836-1enteev7	7	24	are	be	VBP
cord-350836-1enteev7	7	25	key	key	JJ
cord-350836-1enteev7	7	26	protein	protein	NN
cord-350836-1enteev7	7	27	sensors	sensor	NNS
cord-350836-1enteev7	7	28	of	of	IN
cord-350836-1enteev7	7	29	the	the	DT
cord-350836-1enteev7	7	30	pathogen	pathogen	NN
cord-350836-1enteev7	7	31	-	-	HYPH
cord-350836-1enteev7	7	32	associated	associate	VBN
cord-350836-1enteev7	7	33	molecular	molecular	JJ
cord-350836-1enteev7	7	34	patterns	pattern	NNS
cord-350836-1enteev7	7	35	(	(	-LRB-
cord-350836-1enteev7	7	36	PAMPs	pamp	NNS
cord-350836-1enteev7	7	37	)	)	-RRB-
cord-350836-1enteev7	7	38	in	in	IN
cord-350836-1enteev7	7	39	the	the	DT
cord-350836-1enteev7	7	40	form	form	NN
cord-350836-1enteev7	7	41	of	of	IN
cord-350836-1enteev7	7	42	viral	viral	JJ
cord-350836-1enteev7	7	43	double	double	RB
cord-350836-1enteev7	7	44	-	-	HYPH
cord-350836-1enteev7	7	45	stranded	strand	VBN
cord-350836-1enteev7	7	46	RNA	RNA	NNP
cord-350836-1enteev7	7	47	(	(	-LRB-
cord-350836-1enteev7	7	48	dsRNA	dsrna	NN
cord-350836-1enteev7	7	49	)	)	-RRB-
cord-350836-1enteev7	7	50	motifs	motif	NNS
cord-350836-1enteev7	7	51	to	to	TO
cord-350836-1enteev7	7	52	induce	induce	VB
cord-350836-1enteev7	7	53	expression	expression	NN
cord-350836-1enteev7	7	54	of	of	IN
cord-350836-1enteev7	7	55	type	type	NN
cord-350836-1enteev7	7	56	1	1	CD
cord-350836-1enteev7	7	57	interferons	interferon	NNS
cord-350836-1enteev7	7	58	(	(	-LRB-
cord-350836-1enteev7	7	59	IFN1	IFN1	NNP
cord-350836-1enteev7	7	60	)	)	-RRB-
cord-350836-1enteev7	7	61	(	(	-LRB-
cord-350836-1enteev7	7	62	IFNα	IFNα	NNP
cord-350836-1enteev7	7	63	and	and	CC
cord-350836-1enteev7	7	64	IFNβ	IFNβ	NNPS
cord-350836-1enteev7	7	65	)	)	-RRB-
cord-350836-1enteev7	7	66	and	and	CC
cord-350836-1enteev7	7	67	other	other	JJ
cord-350836-1enteev7	7	68	pro	pro	JJ
cord-350836-1enteev7	7	69	-	-	JJ
cord-350836-1enteev7	7	70	inflammatory	inflammatory	JJ
cord-350836-1enteev7	7	71	cytokines	cytokine	NNS
cord-350836-1enteev7	7	72	during	during	IN
cord-350836-1enteev7	7	73	the	the	DT
cord-350836-1enteev7	7	74	early	early	JJ
cord-350836-1enteev7	7	75	stage	stage	NN
cord-350836-1enteev7	7	76	of	of	IN
cord-350836-1enteev7	7	77	viral	viral	JJ
cord-350836-1enteev7	7	78	infection	infection	NN
cord-350836-1enteev7	7	79	.	.	.
cord-350836-1enteev7	8	1	While	while	IN
cord-350836-1enteev7	8	2	RIG	rig	NN
cord-350836-1enteev7	8	3	-	-	:
cord-350836-1enteev7	8	4	I	I	NNP
cord-350836-1enteev7	8	5	and	and	CC
cord-350836-1enteev7	8	6	MDA5	MDA5	NNP
cord-350836-1enteev7	8	7	share	share	VBP
cord-350836-1enteev7	8	8	many	many	JJ
cord-350836-1enteev7	8	9	genetic	genetic	JJ
cord-350836-1enteev7	8	10	,	,	,
cord-350836-1enteev7	8	11	structural	structural	JJ
cord-350836-1enteev7	8	12	and	and	CC
cord-350836-1enteev7	8	13	functional	functional	JJ
cord-350836-1enteev7	8	14	similarities	similarity	NNS
cord-350836-1enteev7	8	15	,	,	,
cord-350836-1enteev7	8	16	there	there	EX
cord-350836-1enteev7	8	17	is	be	VBZ
cord-350836-1enteev7	8	18	increasing	increase	VBG
cord-350836-1enteev7	8	19	evidence	evidence	NN
cord-350836-1enteev7	8	20	that	that	IN
cord-350836-1enteev7	8	21	they	-PRON-	PRP
cord-350836-1enteev7	8	22	can	can	MD
cord-350836-1enteev7	8	23	have	have	VB
cord-350836-1enteev7	8	24	significantly	significantly	RB
cord-350836-1enteev7	8	25	different	different	JJ
cord-350836-1enteev7	8	26	strategies	strategy	NNS
cord-350836-1enteev7	8	27	to	to	TO
cord-350836-1enteev7	8	28	recognize	recognize	VB
cord-350836-1enteev7	8	29	different	different	JJ
cord-350836-1enteev7	8	30	pathogens	pathogen	NNS
cord-350836-1enteev7	8	31	,	,	,
cord-350836-1enteev7	8	32	PAMPs	pamp	NNS
cord-350836-1enteev7	8	33	,	,	,
cord-350836-1enteev7	8	34	and	and	CC
cord-350836-1enteev7	8	35	in	in	IN
cord-350836-1enteev7	8	36	different	different	JJ
cord-350836-1enteev7	8	37	host	host	NN
cord-350836-1enteev7	8	38	species	specie	NNS
cord-350836-1enteev7	8	39	.	.	.
cord-350836-1enteev7	9	1	This	this	DT
cord-350836-1enteev7	9	2	review	review	NN
cord-350836-1enteev7	9	3	article	article	NN
cord-350836-1enteev7	9	4	discusses	discuss	VBZ
cord-350836-1enteev7	9	5	the	the	DT
cord-350836-1enteev7	9	6	similarities	similarity	NNS
cord-350836-1enteev7	9	7	and	and	CC
cord-350836-1enteev7	9	8	differences	difference	NNS
cord-350836-1enteev7	9	9	between	between	IN
cord-350836-1enteev7	9	10	RIG	rig	NN
cord-350836-1enteev7	9	11	-	-	:
cord-350836-1enteev7	9	12	I	I	NNP
cord-350836-1enteev7	9	13	and	and	CC
cord-350836-1enteev7	9	14	MDA5	MDA5	NNP
cord-350836-1enteev7	9	15	from	from	IN
cord-350836-1enteev7	9	16	multiple	multiple	JJ
cord-350836-1enteev7	9	17	perspectives	perspective	NNS
cord-350836-1enteev7	9	18	,	,	,
cord-350836-1enteev7	9	19	including	include	VBG
cord-350836-1enteev7	9	20	their	-PRON-	PRP$
cord-350836-1enteev7	9	21	structures	structure	NNS
cord-350836-1enteev7	9	22	,	,	,
cord-350836-1enteev7	9	23	evolution	evolution	NN
cord-350836-1enteev7	9	24	and	and	CC
cord-350836-1enteev7	9	25	functional	functional	JJ
cord-350836-1enteev7	9	26	relationships	relationship	NNS
cord-350836-1enteev7	9	27	with	with	IN
cord-350836-1enteev7	9	28	other	other	JJ
cord-350836-1enteev7	9	29	cellular	cellular	JJ
cord-350836-1enteev7	9	30	proteins	protein	NNS
cord-350836-1enteev7	9	31	,	,	,
cord-350836-1enteev7	9	32	their	-PRON-	PRP$
cord-350836-1enteev7	9	33	differential	differential	JJ
cord-350836-1enteev7	9	34	mechanisms	mechanism	NNS
cord-350836-1enteev7	9	35	of	of	IN
cord-350836-1enteev7	9	36	distinguishing	distinguish	VBG
cord-350836-1enteev7	9	37	between	between	IN
cord-350836-1enteev7	9	38	host	host	NN
cord-350836-1enteev7	9	39	and	and	CC
cord-350836-1enteev7	9	40	viral	viral	JJ
cord-350836-1enteev7	9	41	dsRNAs	dsRNAs	NNPS
cord-350836-1enteev7	9	42	and	and	CC
cord-350836-1enteev7	9	43	interactions	interaction	NNS
cord-350836-1enteev7	9	44	with	with	IN
cord-350836-1enteev7	9	45	host	host	NN
cord-350836-1enteev7	9	46	and	and	CC
cord-350836-1enteev7	9	47	viral	viral	JJ
cord-350836-1enteev7	9	48	protein	protein	NN
cord-350836-1enteev7	9	49	factors	factor	NNS
cord-350836-1enteev7	9	50	,	,	,
cord-350836-1enteev7	9	51	and	and	CC
cord-350836-1enteev7	9	52	their	-PRON-	PRP$
cord-350836-1enteev7	9	53	immunogenic	immunogenic	JJ
cord-350836-1enteev7	9	54	signaling	signaling	NN
cord-350836-1enteev7	9	55	.	.	.
cord-350836-1enteev7	10	1	A	a	DT
cord-350836-1enteev7	10	2	comprehensive	comprehensive	JJ
cord-350836-1enteev7	10	3	comparative	comparative	JJ
cord-350836-1enteev7	10	4	analysis	analysis	NN
cord-350836-1enteev7	10	5	can	can	MD
cord-350836-1enteev7	10	6	help	help	VB
cord-350836-1enteev7	10	7	inform	inform	VB
cord-350836-1enteev7	10	8	future	future	JJ
cord-350836-1enteev7	10	9	studies	study	NNS
cord-350836-1enteev7	10	10	of	of	IN
cord-350836-1enteev7	10	11	RIG	rig	NN
cord-350836-1enteev7	10	12	-	-	:
cord-350836-1enteev7	10	13	I	I	NNP
cord-350836-1enteev7	10	14	and	and	CC
cord-350836-1enteev7	10	15	MDA5	MDA5	NNP
cord-350836-1enteev7	10	16	in	in	IN
cord-350836-1enteev7	10	17	order	order	NN
cord-350836-1enteev7	10	18	to	to	TO
cord-350836-1enteev7	10	19	fully	fully	RB
cord-350836-1enteev7	10	20	understand	understand	VB
cord-350836-1enteev7	10	21	their	-PRON-	PRP$
cord-350836-1enteev7	10	22	functions	function	NNS
cord-350836-1enteev7	10	23	in	in	IN
cord-350836-1enteev7	10	24	order	order	NN
cord-350836-1enteev7	10	25	to	to	TO
cord-350836-1enteev7	10	26	optimize	optimize	VB
cord-350836-1enteev7	10	27	potential	potential	JJ
cord-350836-1enteev7	10	28	therapeutic	therapeutic	JJ
cord-350836-1enteev7	10	29	approaches	approach	NNS
cord-350836-1enteev7	10	30	targeting	target	VBG
cord-350836-1enteev7	10	31	them	-PRON-	PRP
cord-350836-1enteev7	10	32	.	.	.
cord-350836-1enteev7	11	1	RIG	rig	NN
cord-350836-1enteev7	11	2	-	-	:
cord-350836-1enteev7	11	3	I	i	NN
cord-350836-1enteev7	12	1	(	(	-LRB-
cord-350836-1enteev7	12	2	Retinoic	retinoic	JJ
cord-350836-1enteev7	12	3	acid	acid	NN
cord-350836-1enteev7	12	4	-	-	HYPH
cord-350836-1enteev7	12	5	inducible	inducible	JJ
cord-350836-1enteev7	12	6	gene	gene	NN
cord-350836-1enteev7	12	7	I	i	NN
cord-350836-1enteev7	12	8	)	)	-RRB-
cord-350836-1enteev7	13	1	encoded	encode	VBN
cord-350836-1enteev7	13	2	by	by	IN
cord-350836-1enteev7	13	3	the	the	DT
cord-350836-1enteev7	13	4	DDX58	DDX58	NNP
cord-350836-1enteev7	13	5	gene	gene	NN
cord-350836-1enteev7	13	6	in	in	IN
cord-350836-1enteev7	13	7	the	the	DT
cord-350836-1enteev7	13	8	human	human	JJ
cord-350836-1enteev7	13	9	genome	genome	NN
cord-350836-1enteev7	13	10	(	(	-LRB-
cord-350836-1enteev7	13	11	1	1	CD
cord-350836-1enteev7	13	12	,	,	,
cord-350836-1enteev7	13	13	2	2	CD
cord-350836-1enteev7	13	14	)	)	-RRB-
cord-350836-1enteev7	13	15	and	and	CC
cord-350836-1enteev7	13	16	MDA5	MDA5	NNP
cord-350836-1enteev7	13	17	(	(	-LRB-
cord-350836-1enteev7	13	18	Melanoma	Melanoma	NNP
cord-350836-1enteev7	13	19	Differentiation	differentiation	NN
cord-350836-1enteev7	13	20	-	-	HYPH
cord-350836-1enteev7	13	21	Associated	Associated	NNP
cord-350836-1enteev7	13	22	protein	protein	NN
cord-350836-1enteev7	13	23	5	5	CD
cord-350836-1enteev7	13	24	)	)	-RRB-
cord-350836-1enteev7	13	25	encoded	encode	VBN
cord-350836-1enteev7	13	26	by	by	IN
cord-350836-1enteev7	13	27	the	the	DT
cord-350836-1enteev7	13	28	IFIH1	IFIH1	NNP
cord-350836-1enteev7	13	29	gene	gene	NN
cord-350836-1enteev7	13	30	(	(	-LRB-
cord-350836-1enteev7	13	31	3	3	CD
cord-350836-1enteev7	13	32	,	,	,
cord-350836-1enteev7	13	33	4	4	CD
cord-350836-1enteev7	13	34	)	)	-RRB-
cord-350836-1enteev7	13	35	are	be	VBP
cord-350836-1enteev7	13	36	known	know	VBN
cord-350836-1enteev7	13	37	as	as	IN
cord-350836-1enteev7	13	38	important	important	JJ
cord-350836-1enteev7	13	39	protein	protein	NN
cord-350836-1enteev7	13	40	initiators	initiator	NNS
cord-350836-1enteev7	13	41	of	of	IN
cord-350836-1enteev7	13	42	earliest	early	JJS
cord-350836-1enteev7	13	43	immune	immune	JJ
cord-350836-1enteev7	13	44	responses	response	NNS
cord-350836-1enteev7	13	45	to	to	IN
cord-350836-1enteev7	13	46	viral	viral	JJ
cord-350836-1enteev7	13	47	infection	infection	NN
cord-350836-1enteev7	13	48	.	.	.
cord-350836-1enteev7	14	1	A	a	DT
cord-350836-1enteev7	14	2	relatively	relatively	RB
cord-350836-1enteev7	14	3	large	large	JJ
cord-350836-1enteev7	14	4	body	body	NN
cord-350836-1enteev7	14	5	of	of	IN
cord-350836-1enteev7	14	6	work	work	NN
cord-350836-1enteev7	14	7	has	have	VBZ
cord-350836-1enteev7	14	8	focused	focus	VBN
cord-350836-1enteev7	14	9	on	on	IN
cord-350836-1enteev7	14	10	understanding	understand	VBG
cord-350836-1enteev7	14	11	their	-PRON-	PRP$
cord-350836-1enteev7	14	12	roles	role	NNS
cord-350836-1enteev7	14	13	in	in	IN
cord-350836-1enteev7	14	14	triggering	trigger	VBG
cord-350836-1enteev7	14	15	the	the	DT
cord-350836-1enteev7	14	16	same	same	JJ
cord-350836-1enteev7	14	17	innate	innate	JJ
cord-350836-1enteev7	14	18	immune	immune	JJ
cord-350836-1enteev7	14	19	pathway	pathway	NN
cord-350836-1enteev7	14	20	as	as	IN
cord-350836-1enteev7	14	21	they	-PRON-	PRP
cord-350836-1enteev7	14	22	indeed	indeed	RB
cord-350836-1enteev7	14	23	share	share	VBP
cord-350836-1enteev7	14	24	many	many	JJ
cord-350836-1enteev7	14	25	similarities	similarity	NNS
cord-350836-1enteev7	14	26	at	at	IN
cord-350836-1enteev7	14	27	a	a	DT
cord-350836-1enteev7	14	28	structural	structural	JJ
cord-350836-1enteev7	14	29	and	and	CC
cord-350836-1enteev7	14	30	functional	functional	JJ
cord-350836-1enteev7	14	31	level	level	NN
cord-350836-1enteev7	14	32	.	.	.
cord-350836-1enteev7	15	1	However	however	RB
cord-350836-1enteev7	15	2	,	,	,
cord-350836-1enteev7	15	3	it	-PRON-	PRP
cord-350836-1enteev7	15	4	is	be	VBZ
cord-350836-1enteev7	15	5	becoming	become	VBG
cord-350836-1enteev7	15	6	increasingly	increasingly	RB
cord-350836-1enteev7	15	7	clear	clear	JJ
cord-350836-1enteev7	15	8	that	that	IN
cord-350836-1enteev7	15	9	there	there	EX
cord-350836-1enteev7	15	10	are	be	VBP
cord-350836-1enteev7	15	11	unique	unique	JJ
cord-350836-1enteev7	15	12	differences	difference	NNS
cord-350836-1enteev7	15	13	between	between	IN
cord-350836-1enteev7	15	14	RIG	rig	NN
cord-350836-1enteev7	15	15	-	-	:
cord-350836-1enteev7	15	16	I	I	NNP
cord-350836-1enteev7	15	17	and	and	CC
cord-350836-1enteev7	15	18	MDA5	MDA5	NNP
cord-350836-1enteev7	15	19	,	,	,
cord-350836-1enteev7	15	20	such	such	JJ
cord-350836-1enteev7	15	21	as	as	IN
cord-350836-1enteev7	15	22	their	-PRON-	PRP$
cord-350836-1enteev7	15	23	activation	activation	NN
cord-350836-1enteev7	15	24	mechanisms	mechanism	NNS
cord-350836-1enteev7	15	25	and	and	CC
cord-350836-1enteev7	15	26	contextual	contextual	JJ
cord-350836-1enteev7	15	27	functionalities	functionality	NNS
cord-350836-1enteev7	15	28	,	,	,
cord-350836-1enteev7	15	29	that	that	WDT
cord-350836-1enteev7	15	30	need	need	VBP
cord-350836-1enteev7	15	31	to	to	TO
cord-350836-1enteev7	15	32	be	be	VB
cord-350836-1enteev7	15	33	considered	consider	VBN
cord-350836-1enteev7	15	34	in	in	IN
cord-350836-1enteev7	15	35	order	order	NN
cord-350836-1enteev7	15	36	to	to	TO
cord-350836-1enteev7	15	37	fully	fully	RB
cord-350836-1enteev7	15	38	appreciate	appreciate	VB
cord-350836-1enteev7	15	39	their	-PRON-	PRP$
cord-350836-1enteev7	15	40	individual	individual	JJ
cord-350836-1enteev7	15	41	function	function	NN
cord-350836-1enteev7	15	42	.	.	.
cord-350836-1enteev7	16	1	A	a	DT
cord-350836-1enteev7	16	2	comprehensive	comprehensive	JJ
cord-350836-1enteev7	16	3	analysis	analysis	NN
cord-350836-1enteev7	16	4	of	of	IN
cord-350836-1enteev7	16	5	multiple	multiple	JJ
cord-350836-1enteev7	16	6	aspects	aspect	NNS
cord-350836-1enteev7	16	7	of	of	IN
cord-350836-1enteev7	16	8	RIG	rig	NN
cord-350836-1enteev7	16	9	-	-	:
cord-350836-1enteev7	16	10	I	I	NNP
cord-350836-1enteev7	16	11	and	and	CC
cord-350836-1enteev7	16	12	MDA5	MDA5	NNP
cord-350836-1enteev7	16	13	from	from	IN
cord-350836-1enteev7	16	14	their	-PRON-	PRP$
cord-350836-1enteev7	16	15	evolutionary	evolutionary	JJ
cord-350836-1enteev7	16	16	origins	origin	NNS
cord-350836-1enteev7	16	17	and	and	CC
cord-350836-1enteev7	16	18	behavior	behavior	NN
cord-350836-1enteev7	16	19	among	among	IN
cord-350836-1enteev7	16	20	different	different	JJ
cord-350836-1enteev7	16	21	species	specie	NNS
cord-350836-1enteev7	16	22	to	to	IN
cord-350836-1enteev7	16	23	their	-PRON-	PRP$
cord-350836-1enteev7	16	24	structures	structure	NNS
cord-350836-1enteev7	16	25	and	and	CC
cord-350836-1enteev7	16	26	molecular	molecular	JJ
cord-350836-1enteev7	16	27	signaling	signaling	NN
cord-350836-1enteev7	16	28	will	will	MD
cord-350836-1enteev7	16	29	allow	allow	VB
cord-350836-1enteev7	16	30	for	for	IN
cord-350836-1enteev7	16	31	a	a	DT
cord-350836-1enteev7	16	32	more	more	RBR
cord-350836-1enteev7	16	33	nuanced	nuanced	JJ
cord-350836-1enteev7	16	34	understanding	understanding	NN
cord-350836-1enteev7	16	35	of	of	IN
cord-350836-1enteev7	16	36	their	-PRON-	PRP$
cord-350836-1enteev7	16	37	functional	functional	JJ
cord-350836-1enteev7	16	38	purposes	purpose	NNS
cord-350836-1enteev7	16	39	.	.	.
cord-350836-1enteev7	17	1	The	the	DT
cord-350836-1enteev7	17	2	innate	innate	JJ
cord-350836-1enteev7	17	3	immune	immune	JJ
cord-350836-1enteev7	17	4	response	response	NN
cord-350836-1enteev7	17	5	is	be	VBZ
cord-350836-1enteev7	17	6	a	a	DT
cord-350836-1enteev7	17	7	combination	combination	NN
cord-350836-1enteev7	17	8	of	of	IN
cord-350836-1enteev7	17	9	non	non	JJ
cord-350836-1enteev7	17	10	-	-	JJ
cord-350836-1enteev7	17	11	specific	specific	JJ
cord-350836-1enteev7	17	12	defense	defense	NN
cord-350836-1enteev7	17	13	mechanisms	mechanism	NNS
cord-350836-1enteev7	17	14	by	by	IN
cord-350836-1enteev7	17	15	the	the	DT
cord-350836-1enteev7	17	16	host	host	NN
cord-350836-1enteev7	17	17	that	that	WDT
cord-350836-1enteev7	17	18	are	be	VBP
cord-350836-1enteev7	17	19	critical	critical	JJ
cord-350836-1enteev7	17	20	for	for	IN
cord-350836-1enteev7	17	21	early	early	JJ
cord-350836-1enteev7	17	22	detection	detection	NN
cord-350836-1enteev7	17	23	and	and	CC
cord-350836-1enteev7	17	24	inhibition	inhibition	NN
cord-350836-1enteev7	17	25	of	of	IN
cord-350836-1enteev7	17	26	pathogen	pathogen	NN
cord-350836-1enteev7	17	27	growth	growth	NN
cord-350836-1enteev7	17	28	before	before	IN
cord-350836-1enteev7	17	29	the	the	DT
cord-350836-1enteev7	17	30	adaptive	adaptive	JJ
cord-350836-1enteev7	17	31	immune	immune	JJ
cord-350836-1enteev7	17	32	response	response	NN
cord-350836-1enteev7	17	33	has	have	VBZ
cord-350836-1enteev7	17	34	time	time	NN
cord-350836-1enteev7	17	35	to	to	TO
cord-350836-1enteev7	17	36	produce	produce	VB
cord-350836-1enteev7	17	37	proper	proper	JJ
cord-350836-1enteev7	17	38	cell	cell	NN
cord-350836-1enteev7	17	39	-	-	HYPH
cord-350836-1enteev7	17	40	mediated	mediate	VBN
cord-350836-1enteev7	17	41	immunity	immunity	NN
cord-350836-1enteev7	17	42	,	,	,
cord-350836-1enteev7	17	43	such	such	JJ
cord-350836-1enteev7	17	44	as	as	IN
cord-350836-1enteev7	17	45	the	the	DT
cord-350836-1enteev7	17	46	development	development	NN
cord-350836-1enteev7	17	47	of	of	IN
cord-350836-1enteev7	17	48	antibodies	antibody	NNS
cord-350836-1enteev7	17	49	and	and	CC
cord-350836-1enteev7	17	50	cytotoxic	cytotoxic	JJ
cord-350836-1enteev7	17	51	T	t	NN
cord-350836-1enteev7	17	52	-	-	HYPH
cord-350836-1enteev7	17	53	lymphocyte	lymphocyte	NN
cord-350836-1enteev7	17	54	responses	response	NNS
cord-350836-1enteev7	17	55	(	(	-LRB-
cord-350836-1enteev7	17	56	CTL	CTL	NNP
cord-350836-1enteev7	17	57	)	)	-RRB-
cord-350836-1enteev7	17	58	against	against	IN
cord-350836-1enteev7	17	59	the	the	DT
cord-350836-1enteev7	17	60	invading	invade	VBG
cord-350836-1enteev7	17	61	pathogen	pathogen	NN
cord-350836-1enteev7	17	62	and/or	and/or	CC
cord-350836-1enteev7	17	63	the	the	DT
cord-350836-1enteev7	17	64	pathogen	pathogen	NN
cord-350836-1enteev7	17	65	-	-	HYPH
cord-350836-1enteev7	17	66	infected	infect	VBN
cord-350836-1enteev7	17	67	cells	cell	NNS
cord-350836-1enteev7	17	68	(	(	-LRB-
cord-350836-1enteev7	17	69	5	5	CD
cord-350836-1enteev7	17	70	)	)	-RRB-
cord-350836-1enteev7	17	71	.	.	.
cord-350836-1enteev7	18	1	Cells	cell	NNS
cord-350836-1enteev7	18	2	of	of	IN
cord-350836-1enteev7	18	3	the	the	DT
cord-350836-1enteev7	18	4	innate	innate	JJ
cord-350836-1enteev7	18	5	immune	immune	JJ
cord-350836-1enteev7	18	6	arm	arm	NN
cord-350836-1enteev7	18	7	,	,	,
cord-350836-1enteev7	18	8	such	such	JJ
cord-350836-1enteev7	18	9	as	as	IN
cord-350836-1enteev7	18	10	leukocytes	leukocyte	NNS
cord-350836-1enteev7	18	11	and	and	CC
cord-350836-1enteev7	18	12	epithelial	epithelial	JJ
cord-350836-1enteev7	18	13	cells	cell	NNS
cord-350836-1enteev7	18	14	,	,	,
cord-350836-1enteev7	18	15	are	be	VBP
cord-350836-1enteev7	18	16	able	able	JJ
cord-350836-1enteev7	18	17	recognize	recognize	VB
cord-350836-1enteev7	18	18	general	general	JJ
cord-350836-1enteev7	18	19	components	component	NNS
cord-350836-1enteev7	18	20	of	of	IN
cord-350836-1enteev7	18	21	the	the	DT
cord-350836-1enteev7	18	22	microbes	microbe	NNS
cord-350836-1enteev7	18	23	(	(	-LRB-
cord-350836-1enteev7	18	24	e.g.	e.g.	RB
cord-350836-1enteev7	18	25	,	,	,
cord-350836-1enteev7	18	26	viruses	virus	NNS
cord-350836-1enteev7	18	27	)	)	-RRB-
cord-350836-1enteev7	18	28	that	that	WDT
cord-350836-1enteev7	18	29	are	be	VBP
cord-350836-1enteev7	18	30	shared	share	VBN
cord-350836-1enteev7	18	31	among	among	IN
cord-350836-1enteev7	18	32	related	related	JJ
cord-350836-1enteev7	18	33	microbes	microbe	NNS
cord-350836-1enteev7	18	34	.	.	.
cord-350836-1enteev7	19	1	These	these	DT
cord-350836-1enteev7	19	2	microbial	microbial	JJ
cord-350836-1enteev7	19	3	structures	structure	NNS
cord-350836-1enteev7	19	4	are	be	VBP
cord-350836-1enteev7	19	5	called	call	VBN
cord-350836-1enteev7	19	6	pathogen	pathogen	NN
cord-350836-1enteev7	19	7	-	-	HYPH
cord-350836-1enteev7	19	8	associated	associate	VBN
cord-350836-1enteev7	19	9	molecular	molecular	JJ
cord-350836-1enteev7	19	10	patterns	pattern	NNS
cord-350836-1enteev7	19	11	(	(	-LRB-
cord-350836-1enteev7	19	12	PAMPs	pamp	NNS
cord-350836-1enteev7	19	13	)	)	-RRB-
cord-350836-1enteev7	19	14	(	(	-LRB-
cord-350836-1enteev7	19	15	e.g.	e.g.	RB
cord-350836-1enteev7	19	16	,	,	,
cord-350836-1enteev7	19	17	viral	viral	JJ
cord-350836-1enteev7	19	18	dsRNA	dsrna	NN
cord-350836-1enteev7	19	19	)	)	-RRB-
cord-350836-1enteev7	19	20	that	that	WDT
cord-350836-1enteev7	19	21	are	be	VBP
cord-350836-1enteev7	19	22	specifically	specifically	RB
cord-350836-1enteev7	19	23	recognized	recognize	VBN
cord-350836-1enteev7	19	24	by	by	IN
cord-350836-1enteev7	19	25	the	the	DT
cord-350836-1enteev7	19	26	cellular	cellular	JJ
cord-350836-1enteev7	19	27	pattern	pattern	NN
cord-350836-1enteev7	19	28	recognition	recognition	NN
cord-350836-1enteev7	19	29	receptors	receptor	NNS
cord-350836-1enteev7	19	30	(	(	-LRB-
cord-350836-1enteev7	19	31	PRRs	PRRs	NNP
cord-350836-1enteev7	19	32	)	)	-RRB-
cord-350836-1enteev7	19	33	(	(	-LRB-
cord-350836-1enteev7	19	34	e.g.	e.g.	RB
cord-350836-1enteev7	19	35	,	,	,
cord-350836-1enteev7	19	36	RIG	rig	NN
cord-350836-1enteev7	19	37	-	-	:
cord-350836-1enteev7	19	38	I	I	NNP
cord-350836-1enteev7	19	39	,	,	,
cord-350836-1enteev7	19	40	MDA5	MDA5	NNP
cord-350836-1enteev7	19	41	,	,	,
cord-350836-1enteev7	19	42	or	or	CC
cord-350836-1enteev7	19	43	Tolllike	Tolllike	NNP
cord-350836-1enteev7	19	44	receptors	receptor	NNS
cord-350836-1enteev7	19	45	TLRs	TLRs	NNP
cord-350836-1enteev7	19	46	)	)	-RRB-
cord-350836-1enteev7	19	47	which	which	WDT
cord-350836-1enteev7	19	48	are	be	VBP
cord-350836-1enteev7	19	49	then	then	RB
cord-350836-1enteev7	19	50	activated	activate	VBN
cord-350836-1enteev7	19	51	(	(	-LRB-
cord-350836-1enteev7	19	52	Figure	figure	NN
cord-350836-1enteev7	19	53	1	1	CD
cord-350836-1enteev7	19	54	)	)	-RRB-
cord-350836-1enteev7	19	55	.	.	.
cord-350836-1enteev7	20	1	The	the	DT
cord-350836-1enteev7	20	2	specific	specific	JJ
cord-350836-1enteev7	20	3	signaling	signal	VBG
cord-350836-1enteev7	20	4	mechanisms	mechanism	NNS
cord-350836-1enteev7	20	5	of	of	IN
cord-350836-1enteev7	20	6	RIG	rig	NN
cord-350836-1enteev7	20	7	-	-	:
cord-350836-1enteev7	20	8	I	I	NNP
cord-350836-1enteev7	20	9	and	and	CC
cord-350836-1enteev7	20	10	MDA5	mda5	JJ
cord-350836-1enteev7	20	11	activation	activation	NN
cord-350836-1enteev7	20	12	will	will	MD
cord-350836-1enteev7	20	13	be	be	VB
cord-350836-1enteev7	20	14	discussed	discuss	VBN
cord-350836-1enteev7	20	15	in	in	IN
cord-350836-1enteev7	20	16	detail	detail	NN
cord-350836-1enteev7	20	17	below	below	RB
cord-350836-1enteev7	20	18	.	.	.
cord-350836-1enteev7	21	1	Here	here	RB
cord-350836-1enteev7	21	2	,	,	,
cord-350836-1enteev7	21	3	the	the	DT
cord-350836-1enteev7	21	4	cascade	cascade	NN
cord-350836-1enteev7	21	5	of	of	IN
cord-350836-1enteev7	21	6	event	event	NN
cord-350836-1enteev7	21	7	leading	lead	VBG
cord-350836-1enteev7	21	8	to	to	IN
cord-350836-1enteev7	21	9	IFN1	IFN1	NNP
cord-350836-1enteev7	21	10	production	production	NN
cord-350836-1enteev7	21	11	is	be	VBZ
cord-350836-1enteev7	21	12	briefly	briefly	RB
cord-350836-1enteev7	21	13	summarized	summarize	VBN
cord-350836-1enteev7	21	14	.	.	.
cord-350836-1enteev7	22	1	Upon	upon	IN
cord-350836-1enteev7	22	2	binding	bind	VBG
cord-350836-1enteev7	22	3	to	to	IN
cord-350836-1enteev7	22	4	PAMP	PAMP	NNP
cord-350836-1enteev7	22	5	(	(	-LRB-
cord-350836-1enteev7	22	6	e.g.	e.g.	RB
cord-350836-1enteev7	22	7	,	,	,
cord-350836-1enteev7	22	8	dsRNA	dsrna	NN
cord-350836-1enteev7	22	9	)	)	-RRB-
cord-350836-1enteev7	22	10	,	,	,
cord-350836-1enteev7	22	11	the	the	DT
cord-350836-1enteev7	22	12	activated	activate	VBN
cord-350836-1enteev7	22	13	RIG	rig	NN
cord-350836-1enteev7	22	14	-	-	:
cord-350836-1enteev7	22	15	I	I	NNP
cord-350836-1enteev7	22	16	and	and	CC
cord-350836-1enteev7	22	17	MDA5	MDA5	NNP
cord-350836-1enteev7	22	18	interact	interact	VBP
cord-350836-1enteev7	22	19	with	with	IN
cord-350836-1enteev7	22	20	the	the	DT
cord-350836-1enteev7	22	21	mitochondrial	mitochondrial	JJ
cord-350836-1enteev7	22	22	antiviral	antiviral	JJ
cord-350836-1enteev7	22	23	signaling	signal	VBG
cord-350836-1enteev7	22	24	proteins	protein	NNS
cord-350836-1enteev7	22	25	(	(	-LRB-
cord-350836-1enteev7	22	26	MAVS	MAVS	NNP
cord-350836-1enteev7	22	27	)	)	-RRB-
cord-350836-1enteev7	22	28	,	,	,
cord-350836-1enteev7	22	29	which	which	WDT
cord-350836-1enteev7	22	30	forms	form	VBZ
cord-350836-1enteev7	22	31	a	a	DT
cord-350836-1enteev7	22	32	multilayered	multilayered	JJ
cord-350836-1enteev7	22	33	protein	protein	NN
cord-350836-1enteev7	22	34	complex	complex	NN
cord-350836-1enteev7	22	35	contain	contain	VBP
cord-350836-1enteev7	22	36	several	several	JJ
cord-350836-1enteev7	22	37	different	different	JJ
cord-350836-1enteev7	22	38	proteins	protein	NNS
cord-350836-1enteev7	22	39	(	(	-LRB-
cord-350836-1enteev7	22	40	6	6	CD
cord-350836-1enteev7	22	41	)	)	-RRB-
cord-350836-1enteev7	22	42	(	(	-LRB-
cord-350836-1enteev7	22	43	7	7	LS
cord-350836-1enteev7	22	44	)	)	-RRB-
cord-350836-1enteev7	22	45	(	(	-LRB-
cord-350836-1enteev7	22	46	8)	8)	NNP
cord-350836-1enteev7	22	47	(	(	-LRB-
cord-350836-1enteev7	22	48	9	9	CD
cord-350836-1enteev7	22	49	)	)	-RRB-
cord-350836-1enteev7	22	50	.	.	.
cord-350836-1enteev7	23	1	The	the	DT
cord-350836-1enteev7	23	2	MAVS	MAVS	NNPS
cord-350836-1enteev7	23	3	complex	complex	JJ
cord-350836-1enteev7	23	4	then	then	RB
cord-350836-1enteev7	23	5	catalyzes	catalyze	VBZ
cord-350836-1enteev7	23	6	the	the	DT
cord-350836-1enteev7	23	7	interaction	interaction	NN
cord-350836-1enteev7	23	8	of	of	IN
cord-350836-1enteev7	23	9	inhibitor	inhibitor	NN
cord-350836-1enteev7	23	10	of	of	IN
cord-350836-1enteev7	23	11	nuclear	nuclear	JJ
cord-350836-1enteev7	23	12	factor	factor	NN
cord-350836-1enteev7	23	13	kappa	kappa	NN
cord-350836-1enteev7	23	14	-	-	HYPH
cord-350836-1enteev7	23	15	B	B	NNP
cord-350836-1enteev7	23	16	kinase	kinase	NN
cord-350836-1enteev7	23	17	subunit	subunit	NN
cord-350836-1enteev7	23	18	epsilon	epsilon	NN
cord-350836-1enteev7	23	19	(	(	-LRB-
cord-350836-1enteev7	23	20	IKKε	IKKε	NNP
cord-350836-1enteev7	23	21	)	)	-RRB-
cord-350836-1enteev7	23	22	and	and	CC
cord-350836-1enteev7	23	23	the	the	DT
cord-350836-1enteev7	23	24	serine	serine	NN
cord-350836-1enteev7	23	25	/	/	SYM
cord-350836-1enteev7	23	26	threonine	threonine	NN
cord-350836-1enteev7	23	27	-	-	HYPH
cord-350836-1enteev7	23	28	protein	protein	NN
cord-350836-1enteev7	23	29	kinase	kinase	NN
cord-350836-1enteev7	23	30	1	1	CD
cord-350836-1enteev7	23	31	(	(	-LRB-
cord-350836-1enteev7	23	32	TBK1	TBK1	NNP
cord-350836-1enteev7	23	33	)	)	-RRB-
cord-350836-1enteev7	24	1	(	(	-LRB-
cord-350836-1enteev7	24	2	10	10	CD
cord-350836-1enteev7	24	3	)	)	-RRB-
cord-350836-1enteev7	24	4	(	(	-LRB-
cord-350836-1enteev7	24	5	11	11	CD
cord-350836-1enteev7	24	6	)	)	-RRB-
cord-350836-1enteev7	24	7	(	(	-LRB-
cord-350836-1enteev7	24	8	12	12	CD
cord-350836-1enteev7	24	9	)	)	-RRB-
cord-350836-1enteev7	24	10	,	,	,
cord-350836-1enteev7	24	11	which	which	WDT
cord-350836-1enteev7	24	12	phosphorylate	phosphorylate	VBP
cord-350836-1enteev7	24	13	the	the	DT
cord-350836-1enteev7	24	14	transcription	transcription	NN
cord-350836-1enteev7	24	15	factors	factor	NNS
cord-350836-1enteev7	24	16	interferon	interferon	NN
cord-350836-1enteev7	24	17	regulatory	regulatory	JJ
cord-350836-1enteev7	24	18	factors	factor	NNS
cord-350836-1enteev7	24	19	3	3	CD
cord-350836-1enteev7	24	20	and	and	CC
cord-350836-1enteev7	24	21	7	7	CD
cord-350836-1enteev7	24	22	(	(	-LRB-
cord-350836-1enteev7	24	23	IRF3	IRF3	NNP
cord-350836-1enteev7	24	24	and	and	CC
cord-350836-1enteev7	24	25	IRF7	IRF7	NNP
cord-350836-1enteev7	24	26	)	)	-RRB-
cord-350836-1enteev7	24	27	(	(	-LRB-
cord-350836-1enteev7	24	28	13	13	CD
cord-350836-1enteev7	24	29	)	)	-RRB-
cord-350836-1enteev7	24	30	.	.	.
cord-350836-1enteev7	25	1	Phosphorylated	Phosphorylated	NNP
cord-350836-1enteev7	25	2	p	p	NN
cord-350836-1enteev7	25	3	-	-	:
cord-350836-1enteev7	25	4	IRF7	IRF7	NNP
cord-350836-1enteev7	25	5	(	(	-LRB-
cord-350836-1enteev7	25	6	14	14	CD
cord-350836-1enteev7	25	7	)	)	-RRB-
cord-350836-1enteev7	25	8	and	and	CC
cord-350836-1enteev7	25	9	-pIRF3	-pIRF3	NNP
cord-350836-1enteev7	25	10	(	(	-LRB-
cord-350836-1enteev7	25	11	15	15	CD
cord-350836-1enteev7	25	12	)	)	-RRB-
cord-350836-1enteev7	25	13	factors	factor	NNS
cord-350836-1enteev7	25	14	then	then	RB
cord-350836-1enteev7	25	15	dimerize	dimerize	NNP
cord-350836-1enteev7	25	16	and	and	CC
cord-350836-1enteev7	25	17	translocate	translocate	VB
cord-350836-1enteev7	25	18	into	into	IN
cord-350836-1enteev7	25	19	the	the	DT
cord-350836-1enteev7	25	20	nucleus	nucleus	NN
cord-350836-1enteev7	25	21	,	,	,
cord-350836-1enteev7	25	22	where	where	WRB
cord-350836-1enteev7	25	23	they	-PRON-	PRP
cord-350836-1enteev7	25	24	activate	activate	VBP
cord-350836-1enteev7	25	25	the	the	DT
cord-350836-1enteev7	25	26	expression	expression	NN
cord-350836-1enteev7	25	27	of	of	IN
cord-350836-1enteev7	25	28	the	the	DT
cord-350836-1enteev7	25	29	type	type	NN
cord-350836-1enteev7	25	30	1	1	CD
cord-350836-1enteev7	25	31	interferon	interferon	NN
cord-350836-1enteev7	25	32	genes	gene	NNS
cord-350836-1enteev7	25	33	(	(	-LRB-
cord-350836-1enteev7	25	34	IFN1	IFN1	NNP
cord-350836-1enteev7	25	35	:	:	:
cord-350836-1enteev7	25	36	IFNα	IFNα	NNP
cord-350836-1enteev7	25	37	and	and	CC
cord-350836-1enteev7	25	38	IFNβ	IFNβ	NNP
cord-350836-1enteev7	25	39	)	)	-RRB-
cord-350836-1enteev7	25	40	.	.	.
cord-350836-1enteev7	26	1	IFN1	ifn1	JJ
cord-350836-1enteev7	26	2	proteins	protein	NNS
cord-350836-1enteev7	26	3	are	be	VBP
cord-350836-1enteev7	26	4	then	then	RB
cord-350836-1enteev7	26	5	exported	export	VBN
cord-350836-1enteev7	26	6	out	out	IN
cord-350836-1enteev7	26	7	of	of	IN
cord-350836-1enteev7	26	8	the	the	DT
cord-350836-1enteev7	26	9	cell	cell	NN
cord-350836-1enteev7	26	10	to	to	TO
cord-350836-1enteev7	26	11	activate	activate	VB
cord-350836-1enteev7	26	12	IFN1	IFN1	NNP
cord-350836-1enteev7	26	13	signaling	signal	VBG
cord-350836-1enteev7	26	14	cascade	cascade	NN
cord-350836-1enteev7	26	15	by	by	IN
cord-350836-1enteev7	26	16	binding	bind	VBG
cord-350836-1enteev7	26	17	to	to	IN
cord-350836-1enteev7	26	18	their	-PRON-	PRP$
cord-350836-1enteev7	26	19	receptor	receptor	NN
cord-350836-1enteev7	26	20	(	(	-LRB-
cord-350836-1enteev7	26	21	the	the	DT
cord-350836-1enteev7	26	22	IFNα	IFNα	NNP
cord-350836-1enteev7	26	23	/	/	SYM
cord-350836-1enteev7	26	24	β	β	NN
cord-350836-1enteev7	26	25	receptor	receptor	NN
cord-350836-1enteev7	26	26	or	or	CC
cord-350836-1enteev7	26	27	IFNAR	IFNAR	NNP
cord-350836-1enteev7	26	28	)	)	-RRB-
cord-350836-1enteev7	26	29	either	either	CC
cord-350836-1enteev7	26	30	on	on	IN
cord-350836-1enteev7	26	31	the	the	DT
cord-350836-1enteev7	26	32	same	same	JJ
cord-350836-1enteev7	26	33	cells	cell	NNS
cord-350836-1enteev7	26	34	or	or	CC
cord-350836-1enteev7	26	35	neighboring	neighboring	NN
cord-350836-1enteev7	26	36	cells	cell	NNS
cord-350836-1enteev7	26	37	in	in	IN
cord-350836-1enteev7	26	38	an	an	DT
cord-350836-1enteev7	26	39	autocrine	autocrine	JJ
cord-350836-1enteev7	26	40	or	or	CC
cord-350836-1enteev7	26	41	paracrine	paracrine	JJ
cord-350836-1enteev7	26	42	fashion	fashion	NN
cord-350836-1enteev7	26	43	.	.	.
cord-350836-1enteev7	27	1	This	this	DT
cord-350836-1enteev7	27	2	results	result	VBZ
cord-350836-1enteev7	27	3	in	in	IN
cord-350836-1enteev7	27	4	the	the	DT
cord-350836-1enteev7	27	5	production	production	NN
cord-350836-1enteev7	27	6	of	of	IN
cord-350836-1enteev7	27	7	more	more	JJR
cord-350836-1enteev7	27	8	IFN1	IFN1	NNP
cord-350836-1enteev7	27	9	(	(	-LRB-
cord-350836-1enteev7	27	10	in	in	IN
cord-350836-1enteev7	27	11	a	a	DT
cord-350836-1enteev7	27	12	positive	positive	JJ
cord-350836-1enteev7	27	13	feedback	feedback	NN
cord-350836-1enteev7	27	14	loop	loop	NN
cord-350836-1enteev7	27	15	)	)	-RRB-
cord-350836-1enteev7	27	16	and	and	CC
cord-350836-1enteev7	27	17	a	a	DT
cord-350836-1enteev7	27	18	variety	variety	NN
cord-350836-1enteev7	27	19	of	of	IN
cord-350836-1enteev7	27	20	interferon	interferon	NN
cord-350836-1enteev7	27	21	-	-	HYPH
cord-350836-1enteev7	27	22	stimulated	stimulate	VBN
cord-350836-1enteev7	27	23	genes	gene	NNS
cord-350836-1enteev7	27	24	(	(	-LRB-
cord-350836-1enteev7	27	25	ISGs	ISGs	NNP
cord-350836-1enteev7	27	26	)	)	-RRB-
cord-350836-1enteev7	27	27	,	,	,
cord-350836-1enteev7	27	28	which	which	WDT
cord-350836-1enteev7	27	29	mediate	mediate	VBP
cord-350836-1enteev7	27	30	vasodilation	vasodilation	NN
cord-350836-1enteev7	27	31	near	near	IN
cord-350836-1enteev7	27	32	the	the	DT
cord-350836-1enteev7	27	33	site	site	NN
cord-350836-1enteev7	27	34	of	of	IN
cord-350836-1enteev7	27	35	the	the	DT
cord-350836-1enteev7	27	36	pathogen	pathogen	NN
cord-350836-1enteev7	27	37	infection	infection	NN
cord-350836-1enteev7	27	38	and	and	CC
cord-350836-1enteev7	27	39	uptake	uptake	NN
cord-350836-1enteev7	27	40	of	of	IN
cord-350836-1enteev7	27	41	fluid	fluid	NN
cord-350836-1enteev7	27	42	,	,	,
cord-350836-1enteev7	27	43	recruitment	recruitment	NN
cord-350836-1enteev7	27	44	of	of	IN
cord-350836-1enteev7	27	45	innate	innate	JJ
cord-350836-1enteev7	27	46	immune	immune	JJ
cord-350836-1enteev7	27	47	cells	cell	NNS
cord-350836-1enteev7	27	48	,	,	,
cord-350836-1enteev7	27	49	such	such	JJ
cord-350836-1enteev7	27	50	as	as	IN
cord-350836-1enteev7	27	51	macrophages	macrophage	NNS
cord-350836-1enteev7	27	52	,	,	,
cord-350836-1enteev7	27	53	neutrophils	neutrophil	NNS
cord-350836-1enteev7	27	54	,	,	,
cord-350836-1enteev7	27	55	and	and	CC
cord-350836-1enteev7	27	56	dendritic	dendritic	JJ
cord-350836-1enteev7	27	57	cells	cell	NNS
cord-350836-1enteev7	27	58	to	to	IN
cord-350836-1enteev7	27	59	the	the	DT
cord-350836-1enteev7	27	60	site	site	NN
cord-350836-1enteev7	27	61	of	of	IN
cord-350836-1enteev7	27	62	the	the	DT
cord-350836-1enteev7	27	63	infection	infection	NN
cord-350836-1enteev7	27	64	that	that	WDT
cord-350836-1enteev7	27	65	is	be	VBZ
cord-350836-1enteev7	27	66	aided	aid	VBN
cord-350836-1enteev7	27	67	by	by	IN
cord-350836-1enteev7	27	68	chemokine	chemokine	NN
cord-350836-1enteev7	27	69	gradients	gradient	NNS
cord-350836-1enteev7	27	70	to	to	TO
cord-350836-1enteev7	27	71	mediate	mediate	VB
cord-350836-1enteev7	27	72	innate	innate	JJ
cord-350836-1enteev7	27	73	immune	immune	JJ
cord-350836-1enteev7	27	74	cell	cell	NN
cord-350836-1enteev7	27	75	-	-	HYPH
cord-350836-1enteev7	27	76	mediated	mediate	VBN
cord-350836-1enteev7	27	77	killing	killing	NN
cord-350836-1enteev7	27	78	of	of	IN
cord-350836-1enteev7	27	79	the	the	DT
cord-350836-1enteev7	27	80	infected	infected	JJ
cord-350836-1enteev7	27	81	cells	cell	NNS
cord-350836-1enteev7	27	82	(	(	-LRB-
cord-350836-1enteev7	27	83	16	16	CD
cord-350836-1enteev7	27	84	)	)	-RRB-
cord-350836-1enteev7	27	85	.	.	.
cord-350836-1enteev7	28	1	RIG	rig	NN
cord-350836-1enteev7	28	2	-	-	:
cord-350836-1enteev7	28	3	I	I	NNP
cord-350836-1enteev7	28	4	and	and	CC
cord-350836-1enteev7	28	5	MDA5	MDA5	NNP
cord-350836-1enteev7	28	6	appear	appear	VBP
cord-350836-1enteev7	28	7	to	to	TO
cord-350836-1enteev7	28	8	differentially	differentially	RB
cord-350836-1enteev7	28	9	induce	induce	VB
cord-350836-1enteev7	28	10	IFN1	IFN1	NNP
cord-350836-1enteev7	28	11	in	in	IN
cord-350836-1enteev7	28	12	response	response	NN
cord-350836-1enteev7	28	13	to	to	IN
cord-350836-1enteev7	28	14	different	different	JJ
cord-350836-1enteev7	28	15	viral	viral	JJ
cord-350836-1enteev7	28	16	pathogens	pathogen	NNS
cord-350836-1enteev7	28	17	(	(	-LRB-
cord-350836-1enteev7	28	18	17	17	CD
cord-350836-1enteev7	28	19	)	)	-RRB-
cord-350836-1enteev7	28	20	,	,	,
cord-350836-1enteev7	28	21	with	with	IN
cord-350836-1enteev7	28	22	RIG	rig	NN
cord-350836-1enteev7	28	23	-	-	:
cord-350836-1enteev7	28	24	I	-PRON-	PRP
cord-350836-1enteev7	28	25	generally	generally	RB
cord-350836-1enteev7	28	26	responding	respond	VBG
cord-350836-1enteev7	28	27	most	most	RBS
cord-350836-1enteev7	28	28	potently	potently	RB
cord-350836-1enteev7	28	29	to	to	IN
cord-350836-1enteev7	28	30	negative	negative	JJ
cord-350836-1enteev7	28	31	-	-	HYPH
cord-350836-1enteev7	28	32	strand	strand	NN
cord-350836-1enteev7	28	33	RNA	RNA	NNP
cord-350836-1enteev7	28	34	viruses	virus	NNS
cord-350836-1enteev7	28	35	,	,	,
cord-350836-1enteev7	28	36	such	such	JJ
cord-350836-1enteev7	28	37	as	as	IN
cord-350836-1enteev7	28	38	influenza	influenza	NN
cord-350836-1enteev7	28	39	viruses	virus	NNS
cord-350836-1enteev7	28	40	(	(	-LRB-
cord-350836-1enteev7	28	41	18	18	CD
cord-350836-1enteev7	28	42	,	,	,
cord-350836-1enteev7	28	43	19	19	CD
cord-350836-1enteev7	28	44	)	)	-RRB-
cord-350836-1enteev7	28	45	,	,	,
cord-350836-1enteev7	28	46	bunyaviruses	bunyaviruses	NNP
cord-350836-1enteev7	28	47	(	(	-LRB-
cord-350836-1enteev7	28	48	20	20	CD
cord-350836-1enteev7	28	49	,	,	,
cord-350836-1enteev7	28	50	21	21	CD
cord-350836-1enteev7	28	51	)	)	-RRB-
cord-350836-1enteev7	28	52	,	,	,
cord-350836-1enteev7	28	53	filoviruses	filovirus	NNS
cord-350836-1enteev7	28	54	(	(	-LRB-
cord-350836-1enteev7	28	55	22	22	CD
cord-350836-1enteev7	28	56	)	)	-RRB-
cord-350836-1enteev7	28	57	,	,	,
cord-350836-1enteev7	28	58	and	and	CC
cord-350836-1enteev7	28	59	rhabdoviruses	rhabdovirus	NNS
cord-350836-1enteev7	28	60	(	(	-LRB-
cord-350836-1enteev7	28	61	18	18	CD
cord-350836-1enteev7	28	62	,	,	,
cord-350836-1enteev7	28	63	23	23	CD
cord-350836-1enteev7	28	64	)	)	-RRB-
cord-350836-1enteev7	28	65	as	as	RB
cord-350836-1enteev7	28	66	well	well	RB
cord-350836-1enteev7	28	67	as	as	IN
cord-350836-1enteev7	28	68	the	the	DT
cord-350836-1enteev7	28	69	positive	positive	NN
cord-350836-1enteev7	28	70	-	-	HYPH
cord-350836-1enteev7	28	71	stranded	strand	VBN
cord-350836-1enteev7	28	72	Japanese	japanese	JJ
cord-350836-1enteev7	28	73	encephalitis	encephalitis	RB
cord-350836-1enteev7	28	74	virus	virus	NN
cord-350836-1enteev7	28	75	(	(	-LRB-
cord-350836-1enteev7	28	76	18	18	CD
cord-350836-1enteev7	28	77	)	)	-RRB-
cord-350836-1enteev7	28	78	,	,	,
cord-350836-1enteev7	28	79	while	while	IN
cord-350836-1enteev7	28	80	MDA5	MDA5	NNP
cord-350836-1enteev7	28	81	is	be	VBZ
cord-350836-1enteev7	28	82	activated	activate	VBN
cord-350836-1enteev7	28	83	during	during	IN
cord-350836-1enteev7	28	84	infection	infection	NN
cord-350836-1enteev7	28	85	by	by	IN
cord-350836-1enteev7	28	86	positive	positive	JJ
cord-350836-1enteev7	28	87	-	-	HYPH
cord-350836-1enteev7	28	88	strand	strand	NN
cord-350836-1enteev7	28	89	picornaviruses	picornavirus	NNS
cord-350836-1enteev7	28	90	(	(	-LRB-
cord-350836-1enteev7	28	91	18	18	CD
cord-350836-1enteev7	28	92	,	,	,
cord-350836-1enteev7	28	93	24	24	CD
cord-350836-1enteev7	28	94	,	,	,
cord-350836-1enteev7	28	95	25	25	CD
cord-350836-1enteev7	28	96	)	)	-RRB-
cord-350836-1enteev7	28	97	and	and	CC
cord-350836-1enteev7	28	98	arteriviruses	arteriviruse	NNS
cord-350836-1enteev7	28	99	(	(	-LRB-
cord-350836-1enteev7	28	100	26	26	CD
cord-350836-1enteev7	28	101	,	,	,
cord-350836-1enteev7	28	102	27	27	CD
cord-350836-1enteev7	28	103	)	)	-RRB-
cord-350836-1enteev7	28	104	as	as	RB
cord-350836-1enteev7	28	105	well	well	RB
cord-350836-1enteev7	28	106	as	as	IN
cord-350836-1enteev7	28	107	by	by	IN
cord-350836-1enteev7	28	108	hepatitis	hepatitis	NN
cord-350836-1enteev7	28	109	D	D	NNP
cord-350836-1enteev7	28	110	virus	virus	NN
cord-350836-1enteev7	28	111	(	(	-LRB-
cord-350836-1enteev7	28	112	28	28	CD
cord-350836-1enteev7	28	113	)	)	-RRB-
cord-350836-1enteev7	28	114	,	,	,
cord-350836-1enteev7	28	115	Kaposi	Kaposi	NNP
cord-350836-1enteev7	28	116	's	's	POS
cord-350836-1enteev7	28	117	sarcoma	sarcoma	NN
cord-350836-1enteev7	28	118	-	-	HYPH
cord-350836-1enteev7	28	119	associated	associate	VBN
cord-350836-1enteev7	28	120	herpesvirus	herpesvirus	NN
cord-350836-1enteev7	28	121	(	(	-LRB-
cord-350836-1enteev7	28	122	KSHV	KSHV	NNP
cord-350836-1enteev7	28	123	)	)	-RRB-
cord-350836-1enteev7	28	124	(	(	-LRB-
cord-350836-1enteev7	28	125	29	29	CD
cord-350836-1enteev7	28	126	)	)	-RRB-
cord-350836-1enteev7	28	127	.	.	.
cord-350836-1enteev7	29	1	RIG	rig	NN
cord-350836-1enteev7	29	2	-	-	:
cord-350836-1enteev7	29	3	I	I	NNP
cord-350836-1enteev7	29	4	and	and	CC
cord-350836-1enteev7	29	5	MDA5	MDA5	NNP
cord-350836-1enteev7	29	6	may	may	MD
cord-350836-1enteev7	29	7	also	also	RB
cord-350836-1enteev7	29	8	play	play	VB
cord-350836-1enteev7	29	9	a	a	DT
cord-350836-1enteev7	29	10	role	role	NN
cord-350836-1enteev7	29	11	in	in	IN
cord-350836-1enteev7	29	12	recognizing	recognize	VBG
cord-350836-1enteev7	29	13	non	non	JJ
cord-350836-1enteev7	29	14	-	-	JJ
cord-350836-1enteev7	29	15	viral	viral	JJ
cord-350836-1enteev7	29	16	pathogens	pathogen	NNS
cord-350836-1enteev7	29	17	,	,	,
cord-350836-1enteev7	29	18	as	as	IN
cord-350836-1enteev7	29	19	MDA5	MDA5	NNP
cord-350836-1enteev7	29	20	has	have	VBZ
cord-350836-1enteev7	29	21	been	be	VBN
cord-350836-1enteev7	29	22	found	find	VBN
cord-350836-1enteev7	29	23	to	to	TO
cord-350836-1enteev7	29	24	respond	respond	VB
cord-350836-1enteev7	29	25	to	to	IN
cord-350836-1enteev7	29	26	malaria	malaria	NN
cord-350836-1enteev7	29	27	(	(	-LRB-
cord-350836-1enteev7	29	28	30	30	CD
cord-350836-1enteev7	29	29	)	)	-RRB-
cord-350836-1enteev7	30	1	(	(	-LRB-
cord-350836-1enteev7	30	2	Figure	figure	NN
cord-350836-1enteev7	30	3	2	2	CD
cord-350836-1enteev7	30	4	)	)	-RRB-
cord-350836-1enteev7	30	5	.	.	.
cord-350836-1enteev7	31	1	Neither	neither	DT
cord-350836-1enteev7	31	2	are	be	VBP
cord-350836-1enteev7	31	3	individually	individually	RB
cord-350836-1enteev7	31	4	critical	critical	JJ
cord-350836-1enteev7	31	5	in	in	IN
cord-350836-1enteev7	31	6	reovirus	reovirus	NNP
cord-350836-1enteev7	31	7	(	(	-LRB-
cord-350836-1enteev7	31	8	24	24	CD
cord-350836-1enteev7	31	9	)	)	-RRB-
cord-350836-1enteev7	31	10	and	and	CC
cord-350836-1enteev7	31	11	in	in	IN
cord-350836-1enteev7	31	12	dengue	dengue	NN
cord-350836-1enteev7	31	13	virus	virus	NN
cord-350836-1enteev7	31	14	infection	infection	NN
cord-350836-1enteev7	31	15	(	(	-LRB-
cord-350836-1enteev7	31	16	24	24	CD
cord-350836-1enteev7	31	17	,	,	,
cord-350836-1enteev7	31	18	31	31	CD
cord-350836-1enteev7	31	19	)	)	-RRB-
cord-350836-1enteev7	31	20	but	but	CC
cord-350836-1enteev7	31	21	the	the	DT
cord-350836-1enteev7	31	22	presence	presence	NN
cord-350836-1enteev7	31	23	of	of	IN
cord-350836-1enteev7	31	24	either	either	CC
cord-350836-1enteev7	31	25	in	in	IN
cord-350836-1enteev7	31	26	combination	combination	NN
cord-350836-1enteev7	31	27	with	with	IN
cord-350836-1enteev7	31	28	Toll	Toll	NNP
cord-350836-1enteev7	31	29	-	-	HYPH
cord-350836-1enteev7	31	30	like	like	JJ
cord-350836-1enteev7	31	31	receptor	receptor	NN
cord-350836-1enteev7	31	32	3	3	CD
cord-350836-1enteev7	32	1	(	(	-LRB-
cord-350836-1enteev7	32	2	TLR3	TLR3	NNP
cord-350836-1enteev7	32	3	)	)	-RRB-
cord-350836-1enteev7	32	4	is	be	VBZ
cord-350836-1enteev7	32	5	critical	critical	JJ
cord-350836-1enteev7	32	6	to	to	TO
cord-350836-1enteev7	32	7	have	have	VB
cord-350836-1enteev7	32	8	effective	effective	JJ
cord-350836-1enteev7	32	9	anti	anti	JJ
cord-350836-1enteev7	32	10	-	-	JJ
cord-350836-1enteev7	32	11	viral	viral	JJ
cord-350836-1enteev7	32	12	repsonses	repsonse	NNS
cord-350836-1enteev7	32	13	(	(	-LRB-
cord-350836-1enteev7	32	14	32	32	CD
cord-350836-1enteev7	32	15	)	)	-RRB-
cord-350836-1enteev7	32	16	.	.	.
cord-350836-1enteev7	33	1	Each	each	DT
cord-350836-1enteev7	33	2	serves	serve	VBZ
cord-350836-1enteev7	33	3	an	an	DT
cord-350836-1enteev7	33	4	additive	additive	NN
cord-350836-1enteev7	33	5	role	role	NN
cord-350836-1enteev7	33	6	during	during	IN
cord-350836-1enteev7	33	7	West	West	NNP
cord-350836-1enteev7	33	8	Nile	Nile	NNP
cord-350836-1enteev7	33	9	virus	virus	NN
cord-350836-1enteev7	33	10	infection	infection	NN
cord-350836-1enteev7	33	11	(	(	-LRB-
cord-350836-1enteev7	33	12	33	33	CD
cord-350836-1enteev7	33	13	)	)	-RRB-
cord-350836-1enteev7	33	14	,	,	,
cord-350836-1enteev7	33	15	which	which	WDT
cord-350836-1enteev7	33	16	is	be	VBZ
cord-350836-1enteev7	33	17	likely	likely	RB
cord-350836-1enteev7	33	18	mediated	mediate	VBN
cord-350836-1enteev7	33	19	by	by	IN
cord-350836-1enteev7	33	20	the	the	DT
cord-350836-1enteev7	33	21	production	production	NN
cord-350836-1enteev7	33	22	of	of	IN
cord-350836-1enteev7	33	23	multiple	multiple	JJ
cord-350836-1enteev7	33	24	PAMP	PAMP	NNP
cord-350836-1enteev7	33	25	species	specie	NNS
cord-350836-1enteev7	33	26	in	in	IN
cord-350836-1enteev7	33	27	the	the	DT
cord-350836-1enteev7	33	28	infected	infected	JJ
cord-350836-1enteev7	33	29	cells	cell	NNS
cord-350836-1enteev7	33	30	(	(	-LRB-
cord-350836-1enteev7	33	31	34	34	CD
cord-350836-1enteev7	33	32	)	)	-RRB-
cord-350836-1enteev7	33	33	.	.	.
cord-350836-1enteev7	34	1	Indeed	indeed	RB
cord-350836-1enteev7	34	2	,	,	,
cord-350836-1enteev7	34	3	RIG	rig	NN
cord-350836-1enteev7	34	4	-	-	:
cord-350836-1enteev7	34	5	I	I	NNP
cord-350836-1enteev7	34	6	and	and	CC
cord-350836-1enteev7	34	7	MDA5	MDA5	NNP
cord-350836-1enteev7	34	8	have	have	VBP
cord-350836-1enteev7	34	9	also	also	RB
cord-350836-1enteev7	34	10	been	be	VBN
cord-350836-1enteev7	34	11	shown	show	VBN
cord-350836-1enteev7	34	12	to	to	TO
cord-350836-1enteev7	34	13	recognize	recognize	VB
cord-350836-1enteev7	34	14	different	different	JJ
cord-350836-1enteev7	34	15	sections	section	NNS
cord-350836-1enteev7	34	16	of	of	IN
cord-350836-1enteev7	34	17	the	the	DT
cord-350836-1enteev7	34	18	same	same	JJ
cord-350836-1enteev7	34	19	viral	viral	JJ
cord-350836-1enteev7	34	20	genome	genome	NN
cord-350836-1enteev7	34	21	due	due	IN
cord-350836-1enteev7	34	22	to	to	IN
cord-350836-1enteev7	34	23	their	-PRON-	PRP$
cord-350836-1enteev7	34	24	differing	differ	VBG
cord-350836-1enteev7	34	25	preferences	preference	NNS
cord-350836-1enteev7	34	26	for	for	IN
cord-350836-1enteev7	34	27	RNA	rna	NN
cord-350836-1enteev7	34	28	binding	binding	NN
cord-350836-1enteev7	34	29	(	(	-LRB-
cord-350836-1enteev7	34	30	35	35	CD
cord-350836-1enteev7	34	31	)	)	-RRB-
cord-350836-1enteev7	34	32	,	,	,
cord-350836-1enteev7	34	33	illustrating	illustrate	VBG
cord-350836-1enteev7	34	34	how	how	WRB
cord-350836-1enteev7	34	35	RIG	rig	NN
cord-350836-1enteev7	34	36	-	-	:
cord-350836-1enteev7	34	37	I	I	NNP
cord-350836-1enteev7	34	38	and	and	CC
cord-350836-1enteev7	34	39	MDA5	MDA5	NNP
cord-350836-1enteev7	34	40	can	can	MD
cord-350836-1enteev7	34	41	act	act	VB
cord-350836-1enteev7	34	42	both	both	CC
cord-350836-1enteev7	34	43	independently	independently	RB
cord-350836-1enteev7	34	44	and	and	CC
cord-350836-1enteev7	34	45	synergistically	synergistically	RB
cord-350836-1enteev7	34	46	.	.	.
cord-350836-1enteev7	35	1	This	this	DT
cord-350836-1enteev7	35	2	has	have	VBZ
cord-350836-1enteev7	35	3	also	also	RB
cord-350836-1enteev7	35	4	been	be	VBN
cord-350836-1enteev7	35	5	shown	show	VBN
cord-350836-1enteev7	35	6	functionally	functionally	RB
cord-350836-1enteev7	35	7	in	in	IN
cord-350836-1enteev7	35	8	viruses	virus	NNS
cord-350836-1enteev7	35	9	where	where	WRB
cord-350836-1enteev7	35	10	both	both	CC
cord-350836-1enteev7	35	11	RIG	rig	NN
cord-350836-1enteev7	35	12	-	-	:
cord-350836-1enteev7	35	13	I	I	NNP
cord-350836-1enteev7	35	14	and	and	CC
cord-350836-1enteev7	35	15	MDA5	MDA5	NNP
cord-350836-1enteev7	35	16	have	have	VBP
cord-350836-1enteev7	35	17	been	be	VBN
cord-350836-1enteev7	35	18	found	find	VBN
cord-350836-1enteev7	35	19	to	to	TO
cord-350836-1enteev7	35	20	be	be	VB
cord-350836-1enteev7	35	21	essential	essential	JJ
cord-350836-1enteev7	35	22	to	to	TO
cord-350836-1enteev7	35	23	induce	induce	VB
cord-350836-1enteev7	35	24	the	the	DT
cord-350836-1enteev7	35	25	necessary	necessary	JJ
cord-350836-1enteev7	35	26	levels	level	NNS
cord-350836-1enteev7	35	27	of	of	IN
cord-350836-1enteev7	35	28	IFNβ	IFNβ	NNS
cord-350836-1enteev7	35	29	signaling	signal	VBG
cord-350836-1enteev7	35	30	for	for	IN
cord-350836-1enteev7	35	31	antiviral	antiviral	JJ
cord-350836-1enteev7	35	32	control	control	NN
cord-350836-1enteev7	35	33	against	against	IN
cord-350836-1enteev7	35	34	paramyxovirus	paramyxovirus	NNP
cord-350836-1enteev7	35	35	(	(	-LRB-
cord-350836-1enteev7	35	36	18	18	CD
cord-350836-1enteev7	35	37	,	,	,
cord-350836-1enteev7	35	38	36	36	CD
cord-350836-1enteev7	35	39	-	-	SYM
cord-350836-1enteev7	35	40	38	38	CD
cord-350836-1enteev7	35	41	)	)	-RRB-
cord-350836-1enteev7	35	42	and	and	CC
cord-350836-1enteev7	35	43	rotavirus	rotavirus	JJ
cord-350836-1enteev7	35	44	infections	infection	NNS
cord-350836-1enteev7	35	45	(	(	-LRB-
cord-350836-1enteev7	35	46	39	39	CD
cord-350836-1enteev7	35	47	)	)	-RRB-
cord-350836-1enteev7	35	48	.	.	.
cord-350836-1enteev7	36	1	While	while	IN
cord-350836-1enteev7	36	2	RIG	rig	NN
cord-350836-1enteev7	36	3	-	-	:
cord-350836-1enteev7	36	4	I	I	NNP
cord-350836-1enteev7	36	5	and	and	CC
cord-350836-1enteev7	36	6	MDA5	MDA5	NNP
cord-350836-1enteev7	36	7	participate	participate	VBP
cord-350836-1enteev7	36	8	in	in	IN
cord-350836-1enteev7	36	9	the	the	DT
cord-350836-1enteev7	36	10	IFN1	IFN1	NNP
cord-350836-1enteev7	36	11	signaling	signal	VBG
cord-350836-1enteev7	36	12	pathway	pathway	NN
cord-350836-1enteev7	36	13	(	(	-LRB-
cord-350836-1enteev7	36	14	40	40	CD
cord-350836-1enteev7	36	15	)	)	-RRB-
cord-350836-1enteev7	36	16	,	,	,
cord-350836-1enteev7	36	17	it	-PRON-	PRP
cord-350836-1enteev7	36	18	is	be	VBZ
cord-350836-1enteev7	36	19	clear	clear	JJ
cord-350836-1enteev7	36	20	from	from	IN
cord-350836-1enteev7	36	21	animal	animal	NN
cord-350836-1enteev7	36	22	modeling	modeling	NN
cord-350836-1enteev7	36	23	that	that	WDT
cord-350836-1enteev7	36	24	they	-PRON-	PRP
cord-350836-1enteev7	36	25	might	may	MD
cord-350836-1enteev7	36	26	be	be	VB
cord-350836-1enteev7	36	27	functionally	functionally	RB
cord-350836-1enteev7	36	28	distinct	distinct	JJ
cord-350836-1enteev7	36	29	.	.	.
cord-350836-1enteev7	37	1	While	while	IN
cord-350836-1enteev7	37	2	C57BL/6	C57BL/6	NNP
cord-350836-1enteev7	37	3	MDA5	MDA5	NNP
cord-350836-1enteev7	37	4	KO	KO	NNP
cord-350836-1enteev7	37	5	mice	mouse	NNS
cord-350836-1enteev7	37	6	exhibit	exhibit	VBP
cord-350836-1enteev7	37	7	no	no	DT
cord-350836-1enteev7	37	8	obvious	obvious	JJ
cord-350836-1enteev7	37	9	phenotypes	phenotype	NNS
cord-350836-1enteev7	37	10	(	(	-LRB-
cord-350836-1enteev7	37	11	18	18	CD
cord-350836-1enteev7	37	12	)	)	-RRB-
cord-350836-1enteev7	37	13	,	,	,
cord-350836-1enteev7	37	14	C57BL/6	C57BL/6	NNP
cord-350836-1enteev7	37	15	RIG-	RIG-	NNP
cord-350836-1enteev7	38	1	I	-PRON-	PRP
cord-350836-1enteev7	38	2	KO	KO	NNP
cord-350836-1enteev7	38	3	have	have	VB
cord-350836-1enteev7	38	4	high	high	JJ
cord-350836-1enteev7	38	5	embryonic	embryonic	JJ
cord-350836-1enteev7	38	6	lethality	lethality	NN
cord-350836-1enteev7	38	7	as	as	IN
cord-350836-1enteev7	38	8	they	-PRON-	PRP
cord-350836-1enteev7	38	9	do	do	VBP
cord-350836-1enteev7	38	10	n't	not	RB
cord-350836-1enteev7	38	11	live	live	VB
cord-350836-1enteev7	38	12	past	past	IN
cord-350836-1enteev7	38	13	3	3	CD
cord-350836-1enteev7	38	14	weeks	week	NNS
cord-350836-1enteev7	38	15	of	of	IN
cord-350836-1enteev7	38	16	birth	birth	NN
cord-350836-1enteev7	38	17	and	and	CC
cord-350836-1enteev7	38	18	experience	experience	VB
cord-350836-1enteev7	38	19	growth	growth	NN
cord-350836-1enteev7	38	20	retardation	retardation	NN
cord-350836-1enteev7	38	21	and	and	CC
cord-350836-1enteev7	38	22	liver	liver	NN
cord-350836-1enteev7	38	23	degeneration	degeneration	NN
cord-350836-1enteev7	38	24	(	(	-LRB-
cord-350836-1enteev7	38	25	18	18	CD
cord-350836-1enteev7	38	26	,	,	,
cord-350836-1enteev7	38	27	41	41	CD
cord-350836-1enteev7	38	28	)	)	-RRB-
cord-350836-1enteev7	38	29	.	.	.
cord-350836-1enteev7	39	1	Furthermore	furthermore	RB
cord-350836-1enteev7	39	2	,	,	,
cord-350836-1enteev7	39	3	when	when	WRB
cord-350836-1enteev7	39	4	RIG	rig	NN
cord-350836-1enteev7	39	5	-	-	:
cord-350836-1enteev7	39	6	I	I	NNP
cord-350836-1enteev7	39	7	KO	KO	NNP
cord-350836-1enteev7	39	8	mice	mouse	NNS
cord-350836-1enteev7	39	9	are	be	VBP
cord-350836-1enteev7	39	10	back	back	RB
cord-350836-1enteev7	39	11	crossed	cross	VBN
cord-350836-1enteev7	39	12	onto	onto	IN
cord-350836-1enteev7	39	13	the	the	DT
cord-350836-1enteev7	39	14	more	more	RBR
cord-350836-1enteev7	39	15	genetically	genetically	RB
cord-350836-1enteev7	39	16	flexible	flexible	JJ
cord-350836-1enteev7	39	17	129S1	129s1	NN
cord-350836-1enteev7	39	18	strain	strain	NN
cord-350836-1enteev7	39	19	(	(	-LRB-
cord-350836-1enteev7	39	20	18	18	CD
cord-350836-1enteev7	39	21	)	)	-RRB-
cord-350836-1enteev7	39	22	,	,	,
cord-350836-1enteev7	39	23	these	these	DT
cord-350836-1enteev7	39	24	mice	mouse	NNS
cord-350836-1enteev7	39	25	can	can	MD
cord-350836-1enteev7	39	26	spontaneously	spontaneously	RB
cord-350836-1enteev7	39	27	develop	develop	VB
cord-350836-1enteev7	39	28	colitis	colitis	NN
cord-350836-1enteev7	39	29	symptoms	symptom	NNS
cord-350836-1enteev7	39	30	(	(	-LRB-
cord-350836-1enteev7	39	31	42	42	CD
cord-350836-1enteev7	39	32	)	)	-RRB-
cord-350836-1enteev7	39	33	.	.	.
cord-350836-1enteev7	40	1	Clinical	clinical	JJ
cord-350836-1enteev7	40	2	cases	case	NNS
cord-350836-1enteev7	40	3	with	with	IN
cord-350836-1enteev7	40	4	mutations	mutation	NNS
cord-350836-1enteev7	40	5	in	in	IN
cord-350836-1enteev7	40	6	RIG	rig	NN
cord-350836-1enteev7	40	7	-	-	:
cord-350836-1enteev7	40	8	I	I	NNP
cord-350836-1enteev7	40	9	and	and	CC
cord-350836-1enteev7	40	10	MDA5	MDA5	NNP
cord-350836-1enteev7	40	11	have	have	VBP
cord-350836-1enteev7	40	12	distinct	distinct	JJ
cord-350836-1enteev7	40	13	autoimmune	autoimmune	JJ
cord-350836-1enteev7	40	14	presentations	presentation	NNS
cord-350836-1enteev7	40	15	,	,	,
cord-350836-1enteev7	40	16	with	with	IN
cord-350836-1enteev7	40	17	RIG-	RIG-	NNP
cord-350836-1enteev7	41	1	I	-PRON-	PRP
cord-350836-1enteev7	41	2	mutations	mutation	NNS
cord-350836-1enteev7	41	3	being	be	VBG
cord-350836-1enteev7	41	4	associated	associate	VBN
cord-350836-1enteev7	41	5	with	with	IN
cord-350836-1enteev7	41	6	atypical	atypical	JJ
cord-350836-1enteev7	41	7	Singleton	Singleton	NNP
cord-350836-1enteev7	41	8	-	-	HYPH
cord-350836-1enteev7	41	9	Merten	Merten	NNP
cord-350836-1enteev7	41	10	Syndrome	Syndrome	NNP
cord-350836-1enteev7	41	11	,	,	,
cord-350836-1enteev7	41	12	while	while	IN
cord-350836-1enteev7	41	13	MDA5	mda5	JJ
cord-350836-1enteev7	41	14	mutations	mutation	NNS
cord-350836-1enteev7	41	15	have	have	VBP
cord-350836-1enteev7	41	16	been	be	VBN
cord-350836-1enteev7	41	17	linked	link	VBN
cord-350836-1enteev7	41	18	to	to	IN
cord-350836-1enteev7	41	19	classical	classical	JJ
cord-350836-1enteev7	41	20	Singleton	Singleton	NNP
cord-350836-1enteev7	41	21	-	-	HYPH
cord-350836-1enteev7	41	22	Merten	Merten	NNP
cord-350836-1enteev7	41	23	Syndrome	Syndrome	NNP
cord-350836-1enteev7	41	24	,	,	,
cord-350836-1enteev7	41	25	Aicardi	Aicardi	NNP
cord-350836-1enteev7	41	26	-	-	HYPH
cord-350836-1enteev7	41	27	Goutières	Goutières	NNP
cord-350836-1enteev7	41	28	syndrome	syndrome	NN
cord-350836-1enteev7	41	29	,	,	,
cord-350836-1enteev7	41	30	Systemic	Systemic	NNP
cord-350836-1enteev7	41	31	Lupus	Lupus	NNP
cord-350836-1enteev7	41	32	Erythematosus	Erythematosus	NNP
cord-350836-1enteev7	41	33	,	,	,
cord-350836-1enteev7	41	34	Type	type	NN
cord-350836-1enteev7	41	35	1	1	CD
cord-350836-1enteev7	41	36	Diabetes	diabetes	NN
cord-350836-1enteev7	41	37	and	and	CC
cord-350836-1enteev7	41	38	Graves	Graves	NNP
cord-350836-1enteev7	41	39	disease	disease	NN
cord-350836-1enteev7	41	40	(	(	-LRB-
cord-350836-1enteev7	41	41	43	43	CD
cord-350836-1enteev7	41	42	,	,	,
cord-350836-1enteev7	41	43	44	44	CD
cord-350836-1enteev7	41	44	)	)	-RRB-
cord-350836-1enteev7	42	1	(	(	-LRB-
cord-350836-1enteev7	42	2	Figure	figure	NN
cord-350836-1enteev7	42	3	2	2	CD
cord-350836-1enteev7	42	4	)	)	-RRB-
cord-350836-1enteev7	42	5	.	.	.
cord-350836-1enteev7	43	1	There	there	EX
cord-350836-1enteev7	43	2	is	be	VBZ
cord-350836-1enteev7	43	3	growing	grow	VBG
cord-350836-1enteev7	43	4	evidence	evidence	NN
cord-350836-1enteev7	43	5	that	that	IN
cord-350836-1enteev7	43	6	overt	overt	JJ
cord-350836-1enteev7	43	7	innate	innate	JJ
cord-350836-1enteev7	43	8	-	-	HYPH
cord-350836-1enteev7	43	9	immune	immune	JJ
cord-350836-1enteev7	43	10	interferon	interferon	NN
cord-350836-1enteev7	43	11	signaling	signaling	NN
cord-350836-1enteev7	43	12	plays	play	VBZ
cord-350836-1enteev7	43	13	a	a	DT
cord-350836-1enteev7	43	14	critical	critical	JJ
cord-350836-1enteev7	43	15	role	role	NN
cord-350836-1enteev7	43	16	in	in	IN
cord-350836-1enteev7	43	17	the	the	DT
cord-350836-1enteev7	43	18	development	development	NN
cord-350836-1enteev7	43	19	of	of	IN
cord-350836-1enteev7	43	20	other	other	JJ
cord-350836-1enteev7	43	21	forms	form	NNS
cord-350836-1enteev7	43	22	of	of	IN
cord-350836-1enteev7	43	23	autoimmune	autoimmune	JJ
cord-350836-1enteev7	43	24	conditions	condition	NNS
cord-350836-1enteev7	43	25	(	(	-LRB-
cord-350836-1enteev7	43	26	45	45	CD
cord-350836-1enteev7	43	27	)	)	-RRB-
cord-350836-1enteev7	43	28	.	.	.
cord-350836-1enteev7	44	1	Taken	take	VBN
cord-350836-1enteev7	44	2	together	together	RB
cord-350836-1enteev7	44	3	,	,	,
cord-350836-1enteev7	44	4	this	this	DT
cord-350836-1enteev7	44	5	suggests	suggest	VBZ
cord-350836-1enteev7	44	6	that	that	IN
cord-350836-1enteev7	44	7	RIG	rig	NN
cord-350836-1enteev7	44	8	-	-	:
cord-350836-1enteev7	44	9	I	I	NNP
cord-350836-1enteev7	44	10	and	and	CC
cord-350836-1enteev7	44	11	MDA5	MDA5	NNP
cord-350836-1enteev7	44	12	may	may	MD
cord-350836-1enteev7	44	13	differ	differ	VB
cord-350836-1enteev7	44	14	significantly	significantly	RB
cord-350836-1enteev7	44	15	in	in	IN
cord-350836-1enteev7	44	16	their	-PRON-	PRP$
cord-350836-1enteev7	44	17	roles	role	NNS
cord-350836-1enteev7	44	18	during	during	IN
cord-350836-1enteev7	44	19	development	development	NN
cord-350836-1enteev7	44	20	as	as	RB
cord-350836-1enteev7	44	21	well	well	RB
cord-350836-1enteev7	44	22	as	as	IN
cord-350836-1enteev7	44	23	in	in	IN
cord-350836-1enteev7	44	24	responding	respond	VBG
cord-350836-1enteev7	44	25	to	to	IN
cord-350836-1enteev7	44	26	different	different	JJ
cord-350836-1enteev7	44	27	types	type	NNS
cord-350836-1enteev7	44	28	of	of	IN
cord-350836-1enteev7	44	29	viral	viral	JJ
cord-350836-1enteev7	44	30	infection	infection	NN
cord-350836-1enteev7	44	31	that	that	WDT
cord-350836-1enteev7	44	32	is	be	VBZ
cord-350836-1enteev7	44	33	partially	partially	RB
cord-350836-1enteev7	44	34	dependent	dependent	JJ
cord-350836-1enteev7	44	35	on	on	IN
cord-350836-1enteev7	44	36	the	the	DT
cord-350836-1enteev7	44	37	PAMPs	pamp	NNS
cord-350836-1enteev7	44	38	that	that	WDT
cord-350836-1enteev7	44	39	are	be	VBP
cord-350836-1enteev7	44	40	available	available	JJ
cord-350836-1enteev7	44	41	in	in	IN
cord-350836-1enteev7	44	42	any	any	DT
cord-350836-1enteev7	44	43	given	give	VBN
cord-350836-1enteev7	44	44	context	context	NN
cord-350836-1enteev7	44	45	.	.	.
cord-350836-1enteev7	45	1	There	there	EX
cord-350836-1enteev7	45	2	is	be	VBZ
cord-350836-1enteev7	45	3	also	also	RB
cord-350836-1enteev7	45	4	increasing	increase	VBG
cord-350836-1enteev7	45	5	evidence	evidence	NN
cord-350836-1enteev7	45	6	that	that	IN
cord-350836-1enteev7	45	7	RIG	rig	NN
cord-350836-1enteev7	45	8	-	-	:
cord-350836-1enteev7	45	9	I	I	NNP
cord-350836-1enteev7	45	10	and	and	CC
cord-350836-1enteev7	45	11	MDA5	MDA5	NNP
cord-350836-1enteev7	45	12	have	have	VBP
cord-350836-1enteev7	45	13	additional	additional	JJ
cord-350836-1enteev7	45	14	distinct	distinct	JJ
cord-350836-1enteev7	45	15	molecular	molecular	JJ
cord-350836-1enteev7	45	16	functionalities	functionality	NNS
cord-350836-1enteev7	45	17	in	in	IN
cord-350836-1enteev7	45	18	immune	immune	JJ
cord-350836-1enteev7	45	19	signaling	signaling	NN
cord-350836-1enteev7	45	20	(	(	-LRB-
cord-350836-1enteev7	45	21	43	43	CD
cord-350836-1enteev7	45	22	)	)	-RRB-
cord-350836-1enteev7	45	23	.	.	.
cord-350836-1enteev7	46	1	It	-PRON-	PRP
cord-350836-1enteev7	46	2	is	be	VBZ
cord-350836-1enteev7	46	3	well	well	RB
cord-350836-1enteev7	46	4	-	-	HYPH
cord-350836-1enteev7	46	5	established	establish	VBN
cord-350836-1enteev7	46	6	that	that	IN
cord-350836-1enteev7	46	7	the	the	DT
cord-350836-1enteev7	46	8	interferon	interferon	NN
cord-350836-1enteev7	46	9	regulatory	regulatory	JJ
cord-350836-1enteev7	46	10	factor	factor	NN
cord-350836-1enteev7	46	11	(	(	-LRB-
cord-350836-1enteev7	46	12	IRF	IRF	NNP
cord-350836-1enteev7	46	13	)	)	-RRB-
cord-350836-1enteev7	46	14	and	and	CC
cord-350836-1enteev7	47	1	innate	innate	JJ
cord-350836-1enteev7	47	2	immune	immune	JJ
cord-350836-1enteev7	47	3	NFκB	NFκB	NNP
cord-350836-1enteev7	47	4	cytokine	cytokine	NN
cord-350836-1enteev7	47	5	signaling	signal	VBG
cord-350836-1enteev7	47	6	pathways	pathway	NNS
cord-350836-1enteev7	47	7	have	have	VBP
cord-350836-1enteev7	47	8	many	many	JJ
cord-350836-1enteev7	47	9	areas	area	NNS
cord-350836-1enteev7	47	10	of	of	IN
cord-350836-1enteev7	47	11	cross	cross	NN
cord-350836-1enteev7	47	12	-	-	NN
cord-350836-1enteev7	47	13	regulation	regulation	NN
cord-350836-1enteev7	47	14	and	and	CC
cord-350836-1enteev7	47	15	expression	expression	NN
cord-350836-1enteev7	47	16	(	(	-LRB-
cord-350836-1enteev7	47	17	46	46	CD
cord-350836-1enteev7	47	18	)	)	-RRB-
cord-350836-1enteev7	47	19	.	.	.
cord-350836-1enteev7	48	1	Accordingly	accordingly	RB
cord-350836-1enteev7	48	2	,	,	,
cord-350836-1enteev7	48	3	both	both	CC
cord-350836-1enteev7	48	4	RIG	rig	NN
cord-350836-1enteev7	48	5	-	-	:
cord-350836-1enteev7	48	6	I	I	NNP
cord-350836-1enteev7	48	7	and	and	CC
cord-350836-1enteev7	48	8	MDA5	MDA5	NNP
cord-350836-1enteev7	48	9	have	have	VBP
cord-350836-1enteev7	48	10	been	be	VBN
cord-350836-1enteev7	48	11	shown	show	VBN
cord-350836-1enteev7	48	12	to	to	TO
cord-350836-1enteev7	48	13	activate	activate	VB
cord-350836-1enteev7	48	14	NFκB	NFκB	NNP
cord-350836-1enteev7	48	15	signaling	signal	VBG
cord-350836-1enteev7	48	16	during	during	IN
cord-350836-1enteev7	48	17	RSV	RSV	NNP
cord-350836-1enteev7	48	18	infection	infection	NN
cord-350836-1enteev7	48	19	,	,	,
cord-350836-1enteev7	48	20	but	but	CC
cord-350836-1enteev7	48	21	only	only	JJ
cord-350836-1enteev7	48	22	RIG	rig	NN
cord-350836-1enteev7	48	23	-	-	:
cord-350836-1enteev7	48	24	I	-PRON-	PRP
cord-350836-1enteev7	48	25	appears	appear	VBZ
cord-350836-1enteev7	48	26	to	to	TO
cord-350836-1enteev7	48	27	act	act	VB
cord-350836-1enteev7	48	28	upstream	upstream	RB
cord-350836-1enteev7	48	29	of	of	IN
cord-350836-1enteev7	48	30	the	the	DT
cord-350836-1enteev7	48	31	canonical	canonical	JJ
cord-350836-1enteev7	48	32	IκBα	IκBα	NNP
cord-350836-1enteev7	48	33	-	-	HYPH
cord-350836-1enteev7	48	34	NFκB	NFκB	NNP
cord-350836-1enteev7	48	35	pathway	pathway	NN
cord-350836-1enteev7	48	36	(	(	-LRB-
cord-350836-1enteev7	48	37	47	47	CD
cord-350836-1enteev7	48	38	,	,	,
cord-350836-1enteev7	48	39	48	48	CD
cord-350836-1enteev7	48	40	)	)	-RRB-
cord-350836-1enteev7	49	1	(	(	-LRB-
cord-350836-1enteev7	49	2	Figure	figure	NN
cord-350836-1enteev7	49	3	1	1	CD
cord-350836-1enteev7	49	4	)	)	-RRB-
cord-350836-1enteev7	49	5	.	.	.
cord-350836-1enteev7	50	1	While	while	IN
cord-350836-1enteev7	50	2	both	both	DT
cord-350836-1enteev7	50	3	are	be	VBP
cord-350836-1enteev7	50	4	known	know	VBN
cord-350836-1enteev7	50	5	to	to	TO
cord-350836-1enteev7	50	6	activate	activate	VB
cord-350836-1enteev7	50	7	NFκB	NFκB	NNP
cord-350836-1enteev7	50	8	mediated	mediate	VBN
cord-350836-1enteev7	50	9	expression	expression	NN
cord-350836-1enteev7	50	10	of	of	IN
cord-350836-1enteev7	50	11	IL-6	IL-6	NNP
cord-350836-1enteev7	50	12	and	and	CC
cord-350836-1enteev7	50	13	pro	pro	JJ
cord-350836-1enteev7	50	14	-	-	JJ
cord-350836-1enteev7	50	15	IL-1β	il-1β	JJ
cord-350836-1enteev7	50	16	through	through	IN
cord-350836-1enteev7	50	17	the	the	DT
cord-350836-1enteev7	50	18	interaction	interaction	NN
cord-350836-1enteev7	50	19	of	of	IN
cord-350836-1enteev7	50	20	CARD9	CARD9	NNP
cord-350836-1enteev7	50	21	with	with	IN
cord-350836-1enteev7	50	22	BCL10	BCL10	NNP
cord-350836-1enteev7	50	23	(	(	-LRB-
cord-350836-1enteev7	50	24	49	49	CD
cord-350836-1enteev7	50	25	,	,	,
cord-350836-1enteev7	50	26	50	50	CD
cord-350836-1enteev7	50	27	)	)	-RRB-
cord-350836-1enteev7	50	28	,	,	,
cord-350836-1enteev7	50	29	the	the	DT
cord-350836-1enteev7	50	30	independence	independence	NN
cord-350836-1enteev7	50	31	of	of	IN
cord-350836-1enteev7	50	32	MDA5	MDA5	NNP
cord-350836-1enteev7	50	33	from	from	IN
cord-350836-1enteev7	50	34	the	the	DT
cord-350836-1enteev7	50	35	IκBα	IκBα	NNP
cord-350836-1enteev7	50	36	pathway	pathway	NN
cord-350836-1enteev7	50	37	suggests	suggest	VBZ
cord-350836-1enteev7	50	38	that	that	IN
cord-350836-1enteev7	50	39	it	-PRON-	PRP
cord-350836-1enteev7	50	40	influences	influence	VBZ
cord-350836-1enteev7	50	41	NFκB	nfκb	VBP
cord-350836-1enteev7	50	42	signaling	signal	VBG
cord-350836-1enteev7	50	43	in	in	IN
cord-350836-1enteev7	50	44	other	other	JJ
cord-350836-1enteev7	50	45	as	as	IN
cord-350836-1enteev7	50	46	yet	yet	RB
cord-350836-1enteev7	50	47	uncharacterized	uncharacterized	JJ
cord-350836-1enteev7	50	48	ways	way	NNS
cord-350836-1enteev7	50	49	(	(	-LRB-
cord-350836-1enteev7	50	50	43	43	CD
cord-350836-1enteev7	50	51	)	)	-RRB-
cord-350836-1enteev7	50	52	.	.	.
cord-350836-1enteev7	51	1	A	a	DT
cord-350836-1enteev7	51	2	possible	possible	JJ
cord-350836-1enteev7	51	3	explanation	explanation	NN
cord-350836-1enteev7	51	4	for	for	IN
cord-350836-1enteev7	51	5	MDA5	MDA5	NNP
cord-350836-1enteev7	51	6	's	's	POS
cord-350836-1enteev7	51	7	independence	independence	NN
cord-350836-1enteev7	51	8	from	from	IN
cord-350836-1enteev7	51	9	the	the	DT
cord-350836-1enteev7	51	10	IκBα	IκBα	NNP
cord-350836-1enteev7	51	11	pathway	pathway	NN
cord-350836-1enteev7	51	12	may	may	MD
cord-350836-1enteev7	51	13	be	be	VB
cord-350836-1enteev7	51	14	that	that	IN
cord-350836-1enteev7	51	15	MDA5-mediated	MDA5-mediated	NNP
cord-350836-1enteev7	52	1	NFκB	nfκb	JJ
cord-350836-1enteev7	53	1	(	(	-LRB-
cord-350836-1enteev7	53	2	but	but	CC
cord-350836-1enteev7	53	3	not	not	RB
cord-350836-1enteev7	53	4	IRF	IRF	NNP
cord-350836-1enteev7	53	5	)	)	-RRB-
cord-350836-1enteev7	54	1	signaling	signaling	NN
cord-350836-1enteev7	54	2	requires	require	VBZ
cord-350836-1enteev7	54	3	TRIM25	trim25	NN
cord-350836-1enteev7	54	4	,	,	,
cord-350836-1enteev7	54	5	which	which	WDT
cord-350836-1enteev7	54	6	activates	activate	VBZ
cord-350836-1enteev7	54	7	RIG	rig	NN
cord-350836-1enteev7	55	1	-I	-I	NFP
cord-350836-1enteev7	55	2	by	by	IN
cord-350836-1enteev7	55	3	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	55	4	(	(	-LRB-
cord-350836-1enteev7	55	5	to	to	TO
cord-350836-1enteev7	55	6	be	be	VB
cord-350836-1enteev7	55	7	discussed	discuss	VBN
cord-350836-1enteev7	55	8	in	in	IN
cord-350836-1enteev7	55	9	detail	detail	NN
cord-350836-1enteev7	55	10	below	below	IN
cord-350836-1enteev7	55	11	)	)	-RRB-
cord-350836-1enteev7	55	12	.	.	.
cord-350836-1enteev7	56	1	This	this	DT
cord-350836-1enteev7	56	2	potentially	potentially	RB
cord-350836-1enteev7	56	3	implicates	implicate	VBZ
cord-350836-1enteev7	56	4	TRIM25	trim25	NN
cord-350836-1enteev7	56	5	in	in	IN
cord-350836-1enteev7	56	6	other	other	JJ
cord-350836-1enteev7	56	7	mechanisms	mechanism	NNS
cord-350836-1enteev7	56	8	besides	besides	IN
cord-350836-1enteev7	56	9	activating	activate	VBG
cord-350836-1enteev7	56	10	RIG	rig	NN
cord-350836-1enteev7	56	11	-	-	:
cord-350836-1enteev7	56	12	I	i	NN
cord-350836-1enteev7	56	13	(	(	-LRB-
cord-350836-1enteev7	56	14	51	51	CD
cord-350836-1enteev7	56	15	,	,	,
cord-350836-1enteev7	56	16	52	52	CD
cord-350836-1enteev7	56	17	)	)	-RRB-
cord-350836-1enteev7	56	18	.	.	.
cord-350836-1enteev7	57	1	RIG	rig	NN
cord-350836-1enteev7	57	2	-	-	:
cord-350836-1enteev7	57	3	I	-PRON-	PRP
cord-350836-1enteev7	57	4	(	(	-LRB-
cord-350836-1enteev7	57	5	but	but	CC
cord-350836-1enteev7	57	6	not	not	RB
cord-350836-1enteev7	57	7	MDA5	MDA5	NNP
cord-350836-1enteev7	57	8	)	)	-RRB-
cord-350836-1enteev7	57	9	also	also	RB
cord-350836-1enteev7	57	10	induces	induce	VBZ
cord-350836-1enteev7	57	11	inflammasome	inflammasome	NNP
cord-350836-1enteev7	57	12	assembly	assembly	NN
cord-350836-1enteev7	57	13	-	-	HYPH
cord-350836-1enteev7	57	14	mediated	mediate	VBN
cord-350836-1enteev7	57	15	cleavage	cleavage	NN
cord-350836-1enteev7	57	16	and	and	CC
cord-350836-1enteev7	57	17	maturation	maturation	NN
cord-350836-1enteev7	57	18	of	of	IN
cord-350836-1enteev7	57	19	pro	pro	JJ
cord-350836-1enteev7	57	20	-	-	JJ
cord-350836-1enteev7	57	21	IL-1β	il-1β	JJ
cord-350836-1enteev7	57	22	by	by	IN
cord-350836-1enteev7	57	23	caspase	caspase	NN
cord-350836-1enteev7	57	24	1	1	CD
cord-350836-1enteev7	57	25	(	(	-LRB-
cord-350836-1enteev7	57	26	24	24	CD
cord-350836-1enteev7	57	27	,	,	,
cord-350836-1enteev7	57	28	34	34	CD
cord-350836-1enteev7	57	29	,	,	,
cord-350836-1enteev7	57	30	53	53	CD
cord-350836-1enteev7	57	31	)	)	-RRB-
cord-350836-1enteev7	57	32	.	.	.
cord-350836-1enteev7	58	1	Finally	finally	RB
cord-350836-1enteev7	58	2	,	,	,
cord-350836-1enteev7	58	3	RIG	rig	NN
cord-350836-1enteev7	58	4	-	-	:
cord-350836-1enteev7	58	5	I	-PRON-	PRP
cord-350836-1enteev7	58	6	has	have	VBZ
cord-350836-1enteev7	58	7	been	be	VBN
cord-350836-1enteev7	58	8	shown	show	VBN
cord-350836-1enteev7	58	9	to	to	TO
cord-350836-1enteev7	58	10	inhibit	inhibit	VB
cord-350836-1enteev7	58	11	RNAi	RNAi	NNP
cord-350836-1enteev7	58	12	complexes	complex	NNS
cord-350836-1enteev7	58	13	mediated	mediate	VBN
cord-350836-1enteev7	58	14	by	by	IN
cord-350836-1enteev7	58	15	the	the	DT
cord-350836-1enteev7	58	16	endoribonuclease	endoribonuclease	NN
cord-350836-1enteev7	58	17	Dicer	Dicer	NNP
cord-350836-1enteev7	58	18	,	,	,
cord-350836-1enteev7	58	19	which	which	WDT
cord-350836-1enteev7	58	20	is	be	VBZ
cord-350836-1enteev7	58	21	encoded	encode	VBN
cord-350836-1enteev7	58	22	by	by	IN
cord-350836-1enteev7	58	23	the	the	DT
cord-350836-1enteev7	58	24	DICER1	dicer1	NN
cord-350836-1enteev7	58	25	gene	gene	NN
cord-350836-1enteev7	58	26	and	and	CC
cord-350836-1enteev7	58	27	cleaves	cleave	VBZ
cord-350836-1enteev7	58	28	dsRNA	dsRNA	.
cord-350836-1enteev7	59	1	and	and	CC
cord-350836-1enteev7	59	2	pre	pre	JJ
cord-350836-1enteev7	59	3	-	-	JJ
cord-350836-1enteev7	59	4	micro	micro	JJ
cord-350836-1enteev7	59	5	RNA	RNA	NNP
cord-350836-1enteev7	59	6	into	into	IN
cord-350836-1enteev7	59	7	short	short	JJ
cord-350836-1enteev7	59	8	single	single	RB
cord-350836-1enteev7	59	9	-	-	HYPH
cord-350836-1enteev7	59	10	stranded	strand	VBN
cord-350836-1enteev7	59	11	RNA	rna	NN
cord-350836-1enteev7	59	12	fragments	fragment	NNS
cord-350836-1enteev7	59	13	known	know	VBN
cord-350836-1enteev7	59	14	as	as	IN
cord-350836-1enteev7	59	15	small	small	JJ
cord-350836-1enteev7	59	16	interfering	interfere	VBG
cord-350836-1enteev7	59	17	RNA	RNA	NNP
cord-350836-1enteev7	59	18	(	(	-LRB-
cord-350836-1enteev7	59	19	siRNA	siRNA	NNP
cord-350836-1enteev7	59	20	)	)	-RRB-
cord-350836-1enteev7	59	21	and	and	CC
cord-350836-1enteev7	60	1	microRNA	microRNA	NNP
cord-350836-1enteev7	60	2	FIGURE	FIGURE	NNP
cord-350836-1enteev7	60	3	1	1	CD
cord-350836-1enteev7	60	4	|	|	NNP
cord-350836-1enteev7	60	5	RIG	rig	NN
cord-350836-1enteev7	60	6	-	-	:
cord-350836-1enteev7	60	7	I	I	NNP
cord-350836-1enteev7	60	8	/	/	SYM
cord-350836-1enteev7	60	9	MDA5	MDA5	NNP
cord-350836-1enteev7	60	10	signaling	signal	VBG
cord-350836-1enteev7	60	11	pathway	pathway	NN
cord-350836-1enteev7	60	12	RIG-	RIG-	NNP
cord-350836-1enteev7	61	1	I	-PRON-	PRP
cord-350836-1enteev7	61	2	and	and	CC
cord-350836-1enteev7	61	3	MDA5	MDA5	NNP
cord-350836-1enteev7	61	4	are	be	VBP
cord-350836-1enteev7	61	5	first	first	RB
cord-350836-1enteev7	61	6	activated	activate	VBN
cord-350836-1enteev7	61	7	by	by	IN
cord-350836-1enteev7	61	8	recognition	recognition	NN
cord-350836-1enteev7	61	9	of	of	IN
cord-350836-1enteev7	61	10	PAMP	PAMP	NNP
cord-350836-1enteev7	61	11	dsRNA	dsRNA	NNP
cord-350836-1enteev7	61	12	,	,	,
cord-350836-1enteev7	61	13	which	which	WDT
cord-350836-1enteev7	61	14	causes	cause	VBZ
cord-350836-1enteev7	61	15	them	-PRON-	PRP
cord-350836-1enteev7	61	16	to	to	TO
cord-350836-1enteev7	61	17	interact	interact	VB
cord-350836-1enteev7	61	18	with	with	IN
cord-350836-1enteev7	61	19	MAVS	MAVS	NNPS
cord-350836-1enteev7	61	20	.	.	.
cord-350836-1enteev7	62	1	Following	follow	VBG
cord-350836-1enteev7	62	2	the	the	DT
cord-350836-1enteev7	62	3	activation	activation	NN
cord-350836-1enteev7	62	4	of	of	IN
cord-350836-1enteev7	62	5	MAVS	MAVS	NNPS
cord-350836-1enteev7	62	6	by	by	IN
cord-350836-1enteev7	62	7	RIG	rig	NN
cord-350836-1enteev7	62	8	-	-	:
cord-350836-1enteev7	62	9	I	I	NNP
cord-350836-1enteev7	62	10	/	/	SYM
cord-350836-1enteev7	62	11	MDA5	MDA5	NNP
cord-350836-1enteev7	62	12	,	,	,
cord-350836-1enteev7	62	13	a	a	DT
cord-350836-1enteev7	62	14	molecular	molecular	JJ
cord-350836-1enteev7	62	15	cascade	cascade	NN
cord-350836-1enteev7	62	16	involves	involve	VBZ
cord-350836-1enteev7	62	17	the	the	DT
cord-350836-1enteev7	62	18	interaction	interaction	NN
cord-350836-1enteev7	62	19	of	of	IN
cord-350836-1enteev7	62	20	IKKε	IKKε	NNS
cord-350836-1enteev7	62	21	and	and	CC
cord-350836-1enteev7	62	22	TBK1	TBK1	NNP
cord-350836-1enteev7	62	23	,	,	,
cord-350836-1enteev7	62	24	which	which	WDT
cord-350836-1enteev7	62	25	is	be	VBZ
cord-350836-1enteev7	62	26	followed	follow	VBN
cord-350836-1enteev7	62	27	by	by	IN
cord-350836-1enteev7	62	28	phosphorylation	phosphorylation	NN
cord-350836-1enteev7	62	29	of	of	IN
cord-350836-1enteev7	62	30	the	the	DT
cord-350836-1enteev7	62	31	transcription	transcription	NN
cord-350836-1enteev7	62	32	factors	factor	NNS
cord-350836-1enteev7	62	33	IRF3	IRF3	NNP
cord-350836-1enteev7	62	34	and	and	CC
cord-350836-1enteev7	62	35	IRF7	IRF7	NNP
cord-350836-1enteev7	62	36	,	,	,
cord-350836-1enteev7	62	37	ensure	ensure	VB
cord-350836-1enteev7	62	38	to	to	TO
cord-350836-1enteev7	62	39	translocate	translocate	VB
cord-350836-1enteev7	62	40	the	the	DT
cord-350836-1enteev7	62	41	phosphorylated	phosphorylated	JJ
cord-350836-1enteev7	62	42	p	p	NN
cord-350836-1enteev7	62	43	-	-	:
cord-350836-1enteev7	62	44	IRF3	IRF3	NNP
cord-350836-1enteev7	62	45	and	and	CC
cord-350836-1enteev7	62	46	p	p	NN
cord-350836-1enteev7	62	47	-	-	:
cord-350836-1enteev7	62	48	IRF7	IRF7	NNP
cord-350836-1enteev7	62	49	into	into	IN
cord-350836-1enteev7	62	50	the	the	DT
cord-350836-1enteev7	62	51	nucleus	nucleus	NN
cord-350836-1enteev7	62	52	,	,	,
cord-350836-1enteev7	62	53	where	where	WRB
cord-350836-1enteev7	62	54	they	-PRON-	PRP
cord-350836-1enteev7	62	55	dimerize	dimerize	VBP
cord-350836-1enteev7	62	56	and	and	CC
cord-350836-1enteev7	62	57	bind	bind	VB
cord-350836-1enteev7	62	58	to	to	IN
cord-350836-1enteev7	62	59	transcription	transcription	NN
cord-350836-1enteev7	62	60	factor	factor	NN
cord-350836-1enteev7	62	61	binding	bind	VBG
cord-350836-1enteev7	62	62	sites	site	NNS
cord-350836-1enteev7	62	63	of	of	IN
cord-350836-1enteev7	62	64	the	the	DT
cord-350836-1enteev7	62	65	IFNα	IFNα	NNPS
cord-350836-1enteev7	62	66	and	and	CC
cord-350836-1enteev7	62	67	IFNβ	IFNβ	NNP
cord-350836-1enteev7	62	68	genes	gene	NNS
cord-350836-1enteev7	62	69	to	to	TO
cord-350836-1enteev7	62	70	activate	activate	VB
cord-350836-1enteev7	62	71	their	-PRON-	PRP$
cord-350836-1enteev7	62	72	transcriptions	transcription	NNS
cord-350836-1enteev7	62	73	.	.	.
cord-350836-1enteev7	63	1	Expression	expression	NN
cord-350836-1enteev7	63	2	and	and	CC
cord-350836-1enteev7	63	3	exportation	exportation	NN
cord-350836-1enteev7	63	4	of	of	IN
cord-350836-1enteev7	63	5	these	these	DT
cord-350836-1enteev7	63	6	genes	gene	NNS
cord-350836-1enteev7	63	7	into	into	IN
cord-350836-1enteev7	63	8	the	the	DT
cord-350836-1enteev7	63	9	cellular	cellular	JJ
cord-350836-1enteev7	63	10	milieu	milieu	NN
cord-350836-1enteev7	63	11	trigger	trigger	NN
cord-350836-1enteev7	63	12	the	the	DT
cord-350836-1enteev7	63	13	IFN1	IFN1	NNP
cord-350836-1enteev7	63	14	signaling	signal	VBG
cord-350836-1enteev7	63	15	cascade	cascade	NN
cord-350836-1enteev7	63	16	in	in	IN
cord-350836-1enteev7	63	17	an	an	DT
cord-350836-1enteev7	63	18	autocrine	autocrine	JJ
cord-350836-1enteev7	63	19	or	or	CC
cord-350836-1enteev7	63	20	paracrine	paracrine	JJ
cord-350836-1enteev7	63	21	fashion	fashion	NN
cord-350836-1enteev7	63	22	to	to	TO
cord-350836-1enteev7	63	23	induce	induce	VB
cord-350836-1enteev7	63	24	expression	expression	NN
cord-350836-1enteev7	63	25	of	of	IN
cord-350836-1enteev7	63	26	hundreds	hundred	NNS
cord-350836-1enteev7	63	27	of	of	IN
cord-350836-1enteev7	63	28	interferon	interferon	NN
cord-350836-1enteev7	63	29	stimulated	stimulate	VBD
cord-350836-1enteev7	63	30	genes	gene	NNS
cord-350836-1enteev7	63	31	(	(	-LRB-
cord-350836-1enteev7	63	32	ISGs	ISGs	NNP
cord-350836-1enteev7	63	33	)	)	-RRB-
cord-350836-1enteev7	63	34	and	and	CC
cord-350836-1enteev7	63	35	inflammatory	inflammatory	JJ
cord-350836-1enteev7	63	36	genes	gene	NNS
cord-350836-1enteev7	63	37	to	to	TO
cord-350836-1enteev7	63	38	confer	confer	VB
cord-350836-1enteev7	63	39	antiviral	antiviral	JJ
cord-350836-1enteev7	63	40	resistance	resistance	NN
cord-350836-1enteev7	63	41	.	.	.
cord-350836-1enteev7	64	1	RIG	rig	NN
cord-350836-1enteev7	64	2	-	-	:
cord-350836-1enteev7	64	3	I	I	NNP
cord-350836-1enteev7	64	4	and	and	CC
cord-350836-1enteev7	64	5	MDA5	MDA5	NNP
cord-350836-1enteev7	64	6	also	also	RB
cord-350836-1enteev7	64	7	activate	activate	VBP
cord-350836-1enteev7	64	8	the	the	DT
cord-350836-1enteev7	64	9	NF	nf	NN
cord-350836-1enteev7	64	10	-	-	HYPH
cord-350836-1enteev7	64	11	κB	κB	NNP
cord-350836-1enteev7	64	12	pathway	pathway	NN
cord-350836-1enteev7	64	13	.	.	.
cord-350836-1enteev7	65	1	RIG	rig	NN
cord-350836-1enteev7	65	2	-	-	:
cord-350836-1enteev7	65	3	I	-PRON-	PRP
cord-350836-1enteev7	65	4	appears	appear	VBZ
cord-350836-1enteev7	65	5	to	to	TO
cord-350836-1enteev7	65	6	act	act	VB
cord-350836-1enteev7	65	7	upstream	upstream	RB
cord-350836-1enteev7	65	8	of	of	IN
cord-350836-1enteev7	65	9	the	the	DT
cord-350836-1enteev7	65	10	canonical	canonical	JJ
cord-350836-1enteev7	65	11	pathway	pathway	NN
cord-350836-1enteev7	65	12	,	,	,
cord-350836-1enteev7	65	13	which	which	WDT
cord-350836-1enteev7	65	14	results	result	VBZ
cord-350836-1enteev7	65	15	in	in	IN
cord-350836-1enteev7	65	16	the	the	DT
cord-350836-1enteev7	65	17	translocation	translocation	NN
cord-350836-1enteev7	65	18	of	of	IN
cord-350836-1enteev7	65	19	the	the	DT
cord-350836-1enteev7	65	20	two	two	CD
cord-350836-1enteev7	65	21	functional	functional	JJ
cord-350836-1enteev7	65	22	NF	nf	NN
cord-350836-1enteev7	65	23	-	-	HYPH
cord-350836-1enteev7	65	24	κB	κB	NNP
cord-350836-1enteev7	65	25	units	unit	NNS
cord-350836-1enteev7	65	26	(	(	-LRB-
cord-350836-1enteev7	65	27	p50	p50	NN
cord-350836-1enteev7	65	28	and	and	CC
cord-350836-1enteev7	65	29	p65	p65	CD
cord-350836-1enteev7	65	30	)	)	-RRB-
cord-350836-1enteev7	65	31	into	into	IN
cord-350836-1enteev7	65	32	the	the	DT
cord-350836-1enteev7	65	33	nucleus	nucleus	NN
cord-350836-1enteev7	65	34	,	,	,
cord-350836-1enteev7	65	35	while	while	IN
cord-350836-1enteev7	65	36	MDA5	MDA5	NNP
cord-350836-1enteev7	65	37	appears	appear	VBZ
cord-350836-1enteev7	65	38	to	to	TO
cord-350836-1enteev7	65	39	affect	affect	VB
cord-350836-1enteev7	65	40	NF	nf	NN
cord-350836-1enteev7	65	41	-	-	HYPH
cord-350836-1enteev7	65	42	κB	κb	CD
cord-350836-1enteev7	65	43	expression	expression	NN
cord-350836-1enteev7	65	44	independently	independently	RB
cord-350836-1enteev7	65	45	from	from	IN
cord-350836-1enteev7	65	46	this	this	DT
cord-350836-1enteev7	65	47	pathway	pathway	NN
cord-350836-1enteev7	65	48	.	.	.
cord-350836-1enteev7	66	1	Figure	figure	NN
cord-350836-1enteev7	66	2	created	create	VBN
cord-350836-1enteev7	66	3	using	use	VBG
cord-350836-1enteev7	66	4	BioRender	BioRender	NNP
cord-350836-1enteev7	66	5	software	software	NN
cord-350836-1enteev7	66	6	.	.	.
cord-350836-1enteev7	67	1	(	(	-LRB-
cord-350836-1enteev7	67	2	54	54	CD
cord-350836-1enteev7	67	3	)	)	-RRB-
cord-350836-1enteev7	67	4	,	,	,
cord-350836-1enteev7	67	5	by	by	IN
cord-350836-1enteev7	67	6	interacting	interact	VBG
cord-350836-1enteev7	67	7	with	with	IN
cord-350836-1enteev7	67	8	the	the	DT
cord-350836-1enteev7	67	9	probable	probable	JJ
cord-350836-1enteev7	67	10	ATP	ATP	NNP
cord-350836-1enteev7	67	11	-	-	HYPH
cord-350836-1enteev7	67	12	dependent	dependent	JJ
cord-350836-1enteev7	67	13	RNA	RNA	NNP
cord-350836-1enteev7	67	14	helicase	helicase	NN
cord-350836-1enteev7	67	15	DHX58	DHX58	NNP
cord-350836-1enteev7	67	16	(	(	-LRB-
cord-350836-1enteev7	67	17	also	also	RB
cord-350836-1enteev7	67	18	known	know	VBN
cord-350836-1enteev7	67	19	as	as	IN
cord-350836-1enteev7	67	20	the	the	DT
cord-350836-1enteev7	67	21	Laboratory	Laboratory	NNP
cord-350836-1enteev7	67	22	of	of	IN
cord-350836-1enteev7	67	23	Genetics	Genetics	NNP
cord-350836-1enteev7	67	24	and	and	CC
cord-350836-1enteev7	67	25	Physiology	Physiology	NNP
cord-350836-1enteev7	67	26	2	2	CD
cord-350836-1enteev7	67	27	LGP2	LGP2	NNP
cord-350836-1enteev7	67	28	protein	protein	NN
cord-350836-1enteev7	67	29	)	)	-RRB-
cord-350836-1enteev7	67	30	,	,	,
cord-350836-1enteev7	67	31	which	which	WDT
cord-350836-1enteev7	67	32	inhibits	inhibit	VBZ
cord-350836-1enteev7	67	33	Dicer	dicer	NN
cord-350836-1enteev7	67	34	(	(	-LRB-
cord-350836-1enteev7	67	35	55	55	CD
cord-350836-1enteev7	67	36	)	)	-RRB-
cord-350836-1enteev7	67	37	as	as	RB
cord-350836-1enteev7	67	38	well	well	RB
cord-350836-1enteev7	67	39	as	as	IN
cord-350836-1enteev7	67	40	the	the	DT
cord-350836-1enteev7	67	41	Dicer	dicer	NN
cord-350836-1enteev7	67	42	-	-	HYPH
cord-350836-1enteev7	67	43	complex	complex	JJ
cord-350836-1enteev7	67	44	protein	protein	NN
cord-350836-1enteev7	67	45	TRBP	TRBP	NNP
cord-350836-1enteev7	67	46	(	(	-LRB-
cord-350836-1enteev7	67	47	56	56	CD
cord-350836-1enteev7	67	48	)	)	-RRB-
cord-350836-1enteev7	67	49	.	.	.
cord-350836-1enteev7	68	1	LGP2	LGP2	NNP
cord-350836-1enteev7	68	2	has	have	VBZ
cord-350836-1enteev7	68	3	been	be	VBN
cord-350836-1enteev7	68	4	shown	show	VBN
cord-350836-1enteev7	68	5	to	to	TO
cord-350836-1enteev7	68	6	exhibit	exhibit	VB
cord-350836-1enteev7	68	7	conflicting	conflict	VBG
cord-350836-1enteev7	68	8	effects	effect	NNS
cord-350836-1enteev7	68	9	on	on	IN
cord-350836-1enteev7	68	10	RIG	rig	NN
cord-350836-1enteev7	68	11	-	-	:
cord-350836-1enteev7	68	12	I	I	NNP
cord-350836-1enteev7	68	13	and	and	CC
cord-350836-1enteev7	68	14	MDA5	MDA5	NNP
cord-350836-1enteev7	68	15	signaling	signal	VBG
cord-350836-1enteev7	68	16	(	(	-LRB-
cord-350836-1enteev7	68	17	57	57	CD
cord-350836-1enteev7	68	18	)	)	-RRB-
cord-350836-1enteev7	68	19	(	(	-LRB-
cord-350836-1enteev7	68	20	58	58	CD
cord-350836-1enteev7	68	21	)	)	-RRB-
cord-350836-1enteev7	68	22	(	(	-LRB-
cord-350836-1enteev7	68	23	59	59	CD
cord-350836-1enteev7	68	24	)	)	-RRB-
cord-350836-1enteev7	68	25	,	,	,
cord-350836-1enteev7	68	26	and	and	CC
cord-350836-1enteev7	68	27	future	future	JJ
cord-350836-1enteev7	68	28	studies	study	NNS
cord-350836-1enteev7	68	29	are	be	VBP
cord-350836-1enteev7	68	30	needed	need	VBN
cord-350836-1enteev7	68	31	in	in	IN
cord-350836-1enteev7	68	32	order	order	NN
cord-350836-1enteev7	68	33	to	to	TO
cord-350836-1enteev7	68	34	clarify	clarify	VB
cord-350836-1enteev7	68	35	these	these	DT
cord-350836-1enteev7	68	36	regulatory	regulatory	JJ
cord-350836-1enteev7	68	37	mechanisms	mechanism	NNS
cord-350836-1enteev7	68	38	.	.	.
cord-350836-1enteev7	69	1	RIG	rig	NN
cord-350836-1enteev7	69	2	-	-	:
cord-350836-1enteev7	69	3	I	I	NNP
cord-350836-1enteev7	69	4	and	and	CC
cord-350836-1enteev7	69	5	MDA5	MDA5	NNP
cord-350836-1enteev7	69	6	are	be	VBP
cord-350836-1enteev7	69	7	expressed	express	VBN
cord-350836-1enteev7	69	8	in	in	IN
cord-350836-1enteev7	69	9	all	all	DT
cord-350836-1enteev7	69	10	cell	cell	NN
cord-350836-1enteev7	69	11	types	type	NNS
cord-350836-1enteev7	69	12	(	(	-LRB-
cord-350836-1enteev7	69	13	60	60	CD
cord-350836-1enteev7	69	14	)	)	-RRB-
cord-350836-1enteev7	69	15	,	,	,
cord-350836-1enteev7	69	16	but	but	CC
cord-350836-1enteev7	69	17	are	be	VBP
cord-350836-1enteev7	69	18	most	most	RBS
cord-350836-1enteev7	69	19	well	well	RB
cord-350836-1enteev7	69	20	-	-	HYPH
cord-350836-1enteev7	69	21	known	know	VBN
cord-350836-1enteev7	69	22	for	for	IN
cord-350836-1enteev7	69	23	their	-PRON-	PRP$
cord-350836-1enteev7	69	24	functions	function	NNS
cord-350836-1enteev7	69	25	inside	inside	IN
cord-350836-1enteev7	69	26	innate	innate	JJ
cord-350836-1enteev7	69	27	immune	immune	JJ
cord-350836-1enteev7	69	28	cells	cell	NNS
cord-350836-1enteev7	69	29	,	,	,
cord-350836-1enteev7	69	30	such	such	JJ
cord-350836-1enteev7	69	31	as	as	IN
cord-350836-1enteev7	69	32	macrophages	macrophage	NNS
cord-350836-1enteev7	69	33	,	,	,
cord-350836-1enteev7	69	34	neutrophils	neutrophil	NNS
cord-350836-1enteev7	69	35	,	,	,
cord-350836-1enteev7	69	36	and	and	CC
cord-350836-1enteev7	69	37	dendritic	dendritic	JJ
cord-350836-1enteev7	69	38	cells	cell	NNS
cord-350836-1enteev7	69	39	,	,	,
cord-350836-1enteev7	69	40	as	as	RB
cord-350836-1enteev7	69	41	well	well	RB
cord-350836-1enteev7	69	42	as	as	IN
cord-350836-1enteev7	69	43	in	in	IN
cord-350836-1enteev7	69	44	other	other	JJ
cord-350836-1enteev7	69	45	cells	cell	NNS
cord-350836-1enteev7	69	46	like	like	IN
cord-350836-1enteev7	69	47	mucosal	mucosal	JJ
cord-350836-1enteev7	69	48	epithelial	epithelial	JJ
cord-350836-1enteev7	69	49	cells	cell	NNS
cord-350836-1enteev7	69	50	.	.	.
cord-350836-1enteev7	70	1	They	-PRON-	PRP
cord-350836-1enteev7	70	2	are	be	VBP
cord-350836-1enteev7	70	3	classified	classify	VBN
cord-350836-1enteev7	70	4	as	as	IN
cord-350836-1enteev7	70	5	ATP	ATP	NNP
cord-350836-1enteev7	70	6	-	-	HYPH
cord-350836-1enteev7	70	7	dependent	dependent	JJ
cord-350836-1enteev7	70	8	DExD	DExD	NNS
cord-350836-1enteev7	70	9	/	/	SYM
cord-350836-1enteev7	70	10	H	h	NN
cord-350836-1enteev7	70	11	box	box	NN
cord-350836-1enteev7	70	12	RNA	RNA	NNP
cord-350836-1enteev7	70	13	helicases	helicase	NNS
cord-350836-1enteev7	70	14	.	.	.
cord-350836-1enteev7	71	1	Their	-PRON-	PRP$
cord-350836-1enteev7	71	2	structure	structure	NN
cord-350836-1enteev7	71	3	FIGURE	figure	NN
cord-350836-1enteev7	71	4	2	2	CD
cord-350836-1enteev7	71	5	|	|	NNP
cord-350836-1enteev7	71	6	Venn	Venn	NNP
cord-350836-1enteev7	71	7	diagram	diagram	NN
cord-350836-1enteev7	71	8	comparing	compare	VBG
cord-350836-1enteev7	71	9	the	the	DT
cord-350836-1enteev7	71	10	signaling	signal	VBG
cord-350836-1enteev7	71	11	and	and	CC
cord-350836-1enteev7	71	12	functional	functional	JJ
cord-350836-1enteev7	71	13	similarities	similarity	NNS
cord-350836-1enteev7	71	14	and	and	CC
cord-350836-1enteev7	71	15	differences	difference	NNS
cord-350836-1enteev7	71	16	between	between	IN
cord-350836-1enteev7	71	17	RIG	rig	NN
cord-350836-1enteev7	71	18	-	-	:
cord-350836-1enteev7	71	19	I	I	NNP
cord-350836-1enteev7	71	20	and	and	CC
cord-350836-1enteev7	71	21	MDA5	MDA5	NNP
cord-350836-1enteev7	71	22	.	.	.
cord-350836-1enteev7	72	1	is	be	VBZ
cord-350836-1enteev7	72	2	highly	highly	RB
cord-350836-1enteev7	72	3	helical	helical	JJ
cord-350836-1enteev7	72	4	and	and	CC
cord-350836-1enteev7	72	5	consists	consist	VBZ
cord-350836-1enteev7	72	6	of	of	IN
cord-350836-1enteev7	72	7	two	two	CD
cord-350836-1enteev7	72	8	caspase	caspase	NN
cord-350836-1enteev7	72	9	activating	activate	VBG
cord-350836-1enteev7	72	10	and	and	CC
cord-350836-1enteev7	72	11	recruiting	recruit	VBG
cord-350836-1enteev7	72	12	domains	domain	NNS
cord-350836-1enteev7	72	13	(	(	-LRB-
cord-350836-1enteev7	72	14	CARD	card	NN
cord-350836-1enteev7	72	15	)	)	-RRB-
cord-350836-1enteev7	72	16	at	at	IN
cord-350836-1enteev7	72	17	the	the	DT
cord-350836-1enteev7	72	18	N	n	CD
cord-350836-1enteev7	72	19	terminus	terminus	NN
cord-350836-1enteev7	72	20	of	of	IN
cord-350836-1enteev7	72	21	∼85	∼85	NNP
cord-350836-1enteev7	72	22	amino	amino	NN
cord-350836-1enteev7	72	23	acids	acid	NNS
cord-350836-1enteev7	72	24	each	each	DT
cord-350836-1enteev7	72	25	,	,	,
cord-350836-1enteev7	72	26	followed	follow	VBN
cord-350836-1enteev7	72	27	by	by	IN
cord-350836-1enteev7	72	28	a	a	DT
cord-350836-1enteev7	72	29	flexible	flexible	JJ
cord-350836-1enteev7	72	30	hinge	hinge	NN
cord-350836-1enteev7	72	31	region	region	NN
cord-350836-1enteev7	72	32	and	and	CC
cord-350836-1enteev7	72	33	the	the	DT
cord-350836-1enteev7	72	34	helicase	helicase	NN
cord-350836-1enteev7	72	35	domain	domain	NN
cord-350836-1enteev7	72	36	that	that	WDT
cord-350836-1enteev7	72	37	consists	consist	VBZ
cord-350836-1enteev7	72	38	of	of	IN
cord-350836-1enteev7	72	39	the	the	DT
cord-350836-1enteev7	72	40	RecA	RecA	NNP
cord-350836-1enteev7	72	41	-	-	HYPH
cord-350836-1enteev7	72	42	like	like	JJ
cord-350836-1enteev7	72	43	Hel1	Hel1	NNP
cord-350836-1enteev7	72	44	and	and	CC
cord-350836-1enteev7	72	45	Hel2	Hel2	NNP
cord-350836-1enteev7	72	46	domains	domain	NNS
cord-350836-1enteev7	72	47	with	with	IN
cord-350836-1enteev7	72	48	an	an	DT
cord-350836-1enteev7	72	49	ATP	ATP	NNP
cord-350836-1enteev7	72	50	binding	binding	NN
cord-350836-1enteev7	72	51	and	and	CC
cord-350836-1enteev7	72	52	hydrolyzing	hydrolyzing	NN
cord-350836-1enteev7	72	53	domain	domain	NN
cord-350836-1enteev7	72	54	at	at	IN
cord-350836-1enteev7	72	55	their	-PRON-	PRP$
cord-350836-1enteev7	72	56	interface	interface	NN
cord-350836-1enteev7	72	57	(	(	-LRB-
cord-350836-1enteev7	72	58	Figures	figure	NNS
cord-350836-1enteev7	72	59	3A	3a	NN
cord-350836-1enteev7	72	60	,	,	,
cord-350836-1enteev7	72	61	B	B	NNP
cord-350836-1enteev7	72	62	)	)	-RRB-
cord-350836-1enteev7	72	63	.	.	.
cord-350836-1enteev7	73	1	In	in	IN
cord-350836-1enteev7	73	2	particular	particular	JJ
cord-350836-1enteev7	73	3	,	,	,
cord-350836-1enteev7	73	4	the	the	DT
cord-350836-1enteev7	73	5	structure	structure	NN
cord-350836-1enteev7	73	6	of	of	IN
cord-350836-1enteev7	73	7	the	the	DT
cord-350836-1enteev7	73	8	ATP	ATP	NNP
cord-350836-1enteev7	73	9	binding	binding	NN
cord-350836-1enteev7	73	10	site	site	NN
cord-350836-1enteev7	73	11	distinguishes	distinguish	VBZ
cord-350836-1enteev7	73	12	RIG	rig	NN
cord-350836-1enteev7	73	13	-	-	:
cord-350836-1enteev7	73	14	I	I	NNP
cord-350836-1enteev7	73	15	and	and	CC
cord-350836-1enteev7	73	16	MDA5	MDA5	NNP
cord-350836-1enteev7	73	17	from	from	IN
cord-350836-1enteev7	73	18	other	other	JJ
cord-350836-1enteev7	73	19	helicase	helicase	NN
cord-350836-1enteev7	73	20	proteins	protein	NNS
cord-350836-1enteev7	73	21	,	,	,
cord-350836-1enteev7	73	22	such	such	JJ
cord-350836-1enteev7	73	23	as	as	IN
cord-350836-1enteev7	73	24	Dicer	Dicer	NNP
cord-350836-1enteev7	73	25	.	.	.
cord-350836-1enteev7	74	1	Unlike	unlike	IN
cord-350836-1enteev7	74	2	other	other	JJ
cord-350836-1enteev7	74	3	DExD	DExD	NNS
cord-350836-1enteev7	74	4	/	/	SYM
cord-350836-1enteev7	74	5	H	h	NN
cord-350836-1enteev7	74	6	box	box	NN
cord-350836-1enteev7	74	7	helicases	helicase	NNS
cord-350836-1enteev7	74	8	where	where	WRB
cord-350836-1enteev7	74	9	RNA	RNA	NNP
cord-350836-1enteev7	74	10	binding	binding	NN
cord-350836-1enteev7	74	11	catalyzes	catalyze	VBZ
cord-350836-1enteev7	74	12	the	the	DT
cord-350836-1enteev7	74	13	ATP	ATP	NNP
cord-350836-1enteev7	74	14	binding	binding	NN
cord-350836-1enteev7	74	15	site	site	NN
cord-350836-1enteev7	74	16	to	to	TO
cord-350836-1enteev7	74	17	become	become	VB
cord-350836-1enteev7	74	18	structurally	structurally	RB
cord-350836-1enteev7	74	19	organized	organize	VBN
cord-350836-1enteev7	74	20	,	,	,
cord-350836-1enteev7	74	21	the	the	DT
cord-350836-1enteev7	74	22	ATP	ATP	NNP
cord-350836-1enteev7	74	23	binding	binding	NN
cord-350836-1enteev7	74	24	site	site	NN
cord-350836-1enteev7	74	25	in	in	IN
cord-350836-1enteev7	74	26	RIG	rig	NN
cord-350836-1enteev7	74	27	-	-	:
cord-350836-1enteev7	74	28	I	I	NNP
cord-350836-1enteev7	74	29	and	and	CC
cord-350836-1enteev7	74	30	MDA5	MDA5	NNP
cord-350836-1enteev7	74	31	remains	remain	VBZ
cord-350836-1enteev7	74	32	comparatively	comparatively	RB
cord-350836-1enteev7	74	33	open	open	JJ
cord-350836-1enteev7	74	34	and	and	CC
cord-350836-1enteev7	74	35	structurally	structurally	RB
cord-350836-1enteev7	74	36	dynamic	dynamic	JJ
cord-350836-1enteev7	74	37	following	follow	VBG
cord-350836-1enteev7	74	38	RNA	rna	NN
cord-350836-1enteev7	74	39	binding	binding	NN
cord-350836-1enteev7	74	40	.	.	.
cord-350836-1enteev7	75	1	This	this	DT
cord-350836-1enteev7	75	2	is	be	VBZ
cord-350836-1enteev7	75	3	aided	aid	VBN
cord-350836-1enteev7	75	4	by	by	IN
cord-350836-1enteev7	75	5	the	the	DT
cord-350836-1enteev7	75	6	ATP	ATP	NNP
cord-350836-1enteev7	75	7	binding	binding	NN
cord-350836-1enteev7	75	8	site	site	NN
cord-350836-1enteev7	75	9	being	be	VBG
cord-350836-1enteev7	75	10	formed	form	VBN
cord-350836-1enteev7	75	11	by	by	IN
cord-350836-1enteev7	75	12	an	an	DT
cord-350836-1enteev7	75	13	interface	interface	NN
cord-350836-1enteev7	75	14	between	between	IN
cord-350836-1enteev7	75	15	the	the	DT
cord-350836-1enteev7	75	16	two	two	CD
cord-350836-1enteev7	75	17	Hel	Hel	NNP
cord-350836-1enteev7	75	18	domains	domain	NNS
cord-350836-1enteev7	75	19	,	,	,
cord-350836-1enteev7	75	20	which	which	WDT
cord-350836-1enteev7	75	21	are	be	VBP
cord-350836-1enteev7	75	22	relatively	relatively	RB
cord-350836-1enteev7	75	23	far	far	RB
cord-350836-1enteev7	75	24	apart	apart	RB
cord-350836-1enteev7	75	25	(	(	-LRB-
cord-350836-1enteev7	75	26	64	64	CD
cord-350836-1enteev7	75	27	)	)	-RRB-
cord-350836-1enteev7	75	28	.	.	.
cord-350836-1enteev7	76	1	These	these	DT
cord-350836-1enteev7	76	2	structural	structural	JJ
cord-350836-1enteev7	76	3	features	feature	NNS
cord-350836-1enteev7	76	4	are	be	VBP
cord-350836-1enteev7	76	5	connected	connect	VBN
cord-350836-1enteev7	76	6	by	by	IN
cord-350836-1enteev7	76	7	another	another	DT
cord-350836-1enteev7	76	8	flexible	flexible	JJ
cord-350836-1enteev7	76	9	hinge	hinge	NN
cord-350836-1enteev7	76	10	region	region	NN
cord-350836-1enteev7	76	11	to	to	IN
cord-350836-1enteev7	76	12	the	the	DT
cord-350836-1enteev7	76	13	unique	unique	JJ
cord-350836-1enteev7	76	14	and	and	CC
cord-350836-1enteev7	76	15	predominantly	predominantly	RB
cord-350836-1enteev7	76	16	β	β	NN
cord-350836-1enteev7	76	17	-	-	HYPH
cord-350836-1enteev7	76	18	sheet	sheet	NN
cord-350836-1enteev7	76	19	C	c	NN
cord-350836-1enteev7	76	20	terminal	terminal	NN
cord-350836-1enteev7	76	21	domain	domain	NN
cord-350836-1enteev7	76	22	(	(	-LRB-
cord-350836-1enteev7	76	23	CTD	CTD	NNP
cord-350836-1enteev7	76	24	)	)	-RRB-
cord-350836-1enteev7	76	25	,	,	,
cord-350836-1enteev7	76	26	which	which	WDT
cord-350836-1enteev7	76	27	recognizes	recognize	VBZ
cord-350836-1enteev7	76	28	and	and	CC
cord-350836-1enteev7	76	29	binds	bind	VBZ
cord-350836-1enteev7	76	30	to	to	IN
cord-350836-1enteev7	76	31	RNA	RNA	NNP
cord-350836-1enteev7	76	32	(	(	-LRB-
cord-350836-1enteev7	76	33	65	65	CD
cord-350836-1enteev7	76	34	)	)	-RRB-
cord-350836-1enteev7	76	35	.	.	.
cord-350836-1enteev7	77	1	The	the	DT
cord-350836-1enteev7	77	2	CTD	CTD	NNP
cord-350836-1enteev7	77	3	in	in	IN
cord-350836-1enteev7	77	4	RIG	rig	NN
cord-350836-1enteev7	77	5	-	-	:
cord-350836-1enteev7	77	6	I	I	NNP
cord-350836-1enteev7	77	7	and	and	CC
cord-350836-1enteev7	77	8	MDA5	MDA5	NNP
cord-350836-1enteev7	77	9	contains	contain	VBZ
cord-350836-1enteev7	77	10	a	a	DT
cord-350836-1enteev7	77	11	zinc	zinc	NN
cord-350836-1enteev7	77	12	binding	bind	VBG
cord-350836-1enteev7	77	13	domain	domain	NN
cord-350836-1enteev7	77	14	that	that	WDT
cord-350836-1enteev7	77	15	is	be	VBZ
cord-350836-1enteev7	77	16	related	relate	VBN
cord-350836-1enteev7	77	17	to	to	IN
cord-350836-1enteev7	77	18	those	those	DT
cord-350836-1enteev7	77	19	of	of	IN
cord-350836-1enteev7	77	20	the	the	DT
cord-350836-1enteev7	77	21	GDP	GDP	NNP
cord-350836-1enteev7	77	22	/	/	SYM
cord-350836-1enteev7	77	23	GTP	GTP	NNP
cord-350836-1enteev7	77	24	exchange	exchange	NN
cord-350836-1enteev7	77	25	factors	factor	NNS
cord-350836-1enteev7	77	26	(	(	-LRB-
cord-350836-1enteev7	77	27	66	66	CD
cord-350836-1enteev7	77	28	)	)	-RRB-
cord-350836-1enteev7	77	29	.	.	.
cord-350836-1enteev7	78	1	Each	each	DT
cord-350836-1enteev7	78	2	protein	protein	NN
cord-350836-1enteev7	78	3	also	also	RB
cord-350836-1enteev7	78	4	contains	contain	VBZ
cord-350836-1enteev7	78	5	a	a	DT
cord-350836-1enteev7	78	6	positively	positively	RB
cord-350836-1enteev7	78	7	charged	charge	VBN
cord-350836-1enteev7	78	8	groove	groove	NN
cord-350836-1enteev7	78	9	within	within	IN
cord-350836-1enteev7	78	10	this	this	DT
cord-350836-1enteev7	78	11	domain	domain	NN
cord-350836-1enteev7	78	12	that	that	WDT
cord-350836-1enteev7	78	13	recognizes	recognize	VBZ
cord-350836-1enteev7	78	14	dsRNA	dsrna	NN
cord-350836-1enteev7	78	15	and	and	CC
cord-350836-1enteev7	78	16	this	this	DT
cord-350836-1enteev7	78	17	groove	groove	NN
cord-350836-1enteev7	78	18	is	be	VBZ
cord-350836-1enteev7	78	19	structurally	structurally	RB
cord-350836-1enteev7	78	20	unique	unique	JJ
cord-350836-1enteev7	78	21	in	in	IN
cord-350836-1enteev7	78	22	each	each	DT
cord-350836-1enteev7	78	23	protein	protein	NN
cord-350836-1enteev7	78	24	,	,	,
cord-350836-1enteev7	78	25	potentially	potentially	RB
cord-350836-1enteev7	78	26	explaining	explain	VBG
cord-350836-1enteev7	78	27	their	-PRON-	PRP$
cord-350836-1enteev7	78	28	different	different	JJ
cord-350836-1enteev7	78	29	RNA	RNA	NNP
cord-350836-1enteev7	78	30	binding	binding	NN
cord-350836-1enteev7	78	31	preferences	preference	NNS
cord-350836-1enteev7	78	32	(	(	-LRB-
cord-350836-1enteev7	78	33	66	66	CD
cord-350836-1enteev7	78	34	)	)	-RRB-
cord-350836-1enteev7	78	35	.	.	.
cord-350836-1enteev7	79	1	RIG	rig	NN
cord-350836-1enteev7	79	2	-	-	:
cord-350836-1enteev7	79	3	I	-PRON-	PRP
cord-350836-1enteev7	79	4	primarily	primarily	RB
cord-350836-1enteev7	79	5	recognizes	recognize	VBZ
cord-350836-1enteev7	79	6	short	short	JJ
cord-350836-1enteev7	79	7	double	double	RB
cord-350836-1enteev7	79	8	-	-	HYPH
cord-350836-1enteev7	79	9	stranded	strand	VBN
cord-350836-1enteev7	79	10	RNA	RNA	NNP
cord-350836-1enteev7	79	11	with	with	IN
cord-350836-1enteev7	79	12	5	5	CD
cord-350836-1enteev7	79	13	′	′	CD
cord-350836-1enteev7	79	14	triphosphate	triphosphate	NN
cord-350836-1enteev7	79	15	groups	group	NNS
cord-350836-1enteev7	79	16	(	(	-LRB-
cord-350836-1enteev7	79	17	67	67	CD
cord-350836-1enteev7	79	18	)	)	-RRB-
cord-350836-1enteev7	80	1	(	(	-LRB-
cord-350836-1enteev7	80	2	68	68	CD
cord-350836-1enteev7	80	3	)	)	-RRB-
cord-350836-1enteev7	81	1	(	(	-LRB-
cord-350836-1enteev7	81	2	69	69	CD
cord-350836-1enteev7	81	3	)	)	-RRB-
cord-350836-1enteev7	82	1	(	(	-LRB-
cord-350836-1enteev7	82	2	70	70	CD
cord-350836-1enteev7	82	3	)	)	-RRB-
cord-350836-1enteev7	82	4	(	(	-LRB-
cord-350836-1enteev7	82	5	71	71	CD
cord-350836-1enteev7	82	6	)	)	-RRB-
cord-350836-1enteev7	82	7	(	(	-LRB-
cord-350836-1enteev7	82	8	72	72	CD
cord-350836-1enteev7	82	9	)	)	-RRB-
cord-350836-1enteev7	82	10	(	(	-LRB-
cord-350836-1enteev7	82	11	73	73	CD
cord-350836-1enteev7	82	12	)	)	-RRB-
cord-350836-1enteev7	82	13	(	(	-LRB-
cord-350836-1enteev7	82	14	74	74	CD
cord-350836-1enteev7	82	15	)	)	-RRB-
cord-350836-1enteev7	82	16	(	(	-LRB-
cord-350836-1enteev7	82	17	75	75	CD
cord-350836-1enteev7	82	18	)	)	-RRB-
cord-350836-1enteev7	82	19	,	,	,
cord-350836-1enteev7	82	20	while	while	IN
cord-350836-1enteev7	82	21	MDA5	MDA5	NNP
cord-350836-1enteev7	82	22	primarily	primarily	RB
cord-350836-1enteev7	82	23	recognizes	recognize	VBZ
cord-350836-1enteev7	82	24	long	long	JJ
cord-350836-1enteev7	82	25	double	double	RB
cord-350836-1enteev7	82	26	-	-	HYPH
cord-350836-1enteev7	82	27	stranded	strand	VBN
cord-350836-1enteev7	82	28	RNA	RNA	NNP
cord-350836-1enteev7	82	29	(	(	-LRB-
cord-350836-1enteev7	82	30	76	76	CD
cord-350836-1enteev7	82	31	)	)	-RRB-
cord-350836-1enteev7	82	32	(	(	-LRB-
cord-350836-1enteev7	82	33	77	77	CD
cord-350836-1enteev7	82	34	)	)	-RRB-
cord-350836-1enteev7	82	35	(	(	-LRB-
cord-350836-1enteev7	82	36	78	78	CD
cord-350836-1enteev7	82	37	)	)	-RRB-
cord-350836-1enteev7	82	38	(	(	-LRB-
cord-350836-1enteev7	82	39	79	79	CD
cord-350836-1enteev7	82	40	)	)	-RRB-
cord-350836-1enteev7	82	41	(	(	-LRB-
cord-350836-1enteev7	82	42	to	to	TO
cord-350836-1enteev7	82	43	be	be	VB
cord-350836-1enteev7	82	44	discussed	discuss	VBN
cord-350836-1enteev7	82	45	in	in	IN
cord-350836-1enteev7	82	46	detail	detail	NN
cord-350836-1enteev7	82	47	below	below	RB
cord-350836-1enteev7	82	48	.	.	.
cord-350836-1enteev7	82	49	)	)	-RRB-
cord-350836-1enteev7	83	1	It	-PRON-	PRP
cord-350836-1enteev7	83	2	is	be	VBZ
cord-350836-1enteev7	83	3	notable	notable	JJ
cord-350836-1enteev7	83	4	in	in	IN
cord-350836-1enteev7	83	5	this	this	DT
cord-350836-1enteev7	83	6	regard	regard	NN
cord-350836-1enteev7	83	7	that	that	IN
cord-350836-1enteev7	83	8	the	the	DT
cord-350836-1enteev7	83	9	Hel	Hel	NNP
cord-350836-1enteev7	83	10	-	-	HYPH
cord-350836-1enteev7	83	11	CTD	CTD	NNP
cord-350836-1enteev7	83	12	motifs	motif	NNS
cord-350836-1enteev7	83	13	adopt	adopt	VBP
cord-350836-1enteev7	83	14	different	different	JJ
cord-350836-1enteev7	83	15	orientations	orientation	NNS
cord-350836-1enteev7	83	16	relative	relative	JJ
cord-350836-1enteev7	83	17	to	to	IN
cord-350836-1enteev7	83	18	dsRNA	dsrna	NN
cord-350836-1enteev7	83	19	in	in	IN
cord-350836-1enteev7	83	20	RIG	rig	NN
cord-350836-1enteev7	83	21	-	-	:
cord-350836-1enteev7	83	22	I	I	NNP
cord-350836-1enteev7	83	23	and	and	CC
cord-350836-1enteev7	83	24	MDA5	MDA5	NNP
cord-350836-1enteev7	83	25	.	.	.
cord-350836-1enteev7	84	1	Specifically	specifically	RB
cord-350836-1enteev7	84	2	,	,	,
cord-350836-1enteev7	84	3	the	the	DT
cord-350836-1enteev7	84	4	RIG	rig	NN
cord-350836-1enteev7	84	5	-	-	:
cord-350836-1enteev7	84	6	I	I	NNP
cord-350836-1enteev7	84	7	Hel	Hel	NNP
cord-350836-1enteev7	84	8	-	-	HYPH
cord-350836-1enteev7	84	9	CTD	CTD	NNP
cord-350836-1enteev7	84	10	domain	domain	NN
cord-350836-1enteev7	84	11	is	be	VBZ
cord-350836-1enteev7	84	12	tilted	tilt	VBN
cord-350836-1enteev7	84	13	relative	relative	JJ
cord-350836-1enteev7	84	14	to	to	IN
cord-350836-1enteev7	84	15	dsRNA	dsrna	NN
cord-350836-1enteev7	84	16	with	with	IN
cord-350836-1enteev7	84	17	the	the	DT
cord-350836-1enteev7	84	18	CTD	CTD	NNP
cord-350836-1enteev7	84	19	interacting	interact	VBG
cord-350836-1enteev7	84	20	with	with	IN
cord-350836-1enteev7	84	21	the	the	DT
cord-350836-1enteev7	84	22	5	5	CD
cord-350836-1enteev7	84	23	′	′	CD
cord-350836-1enteev7	84	24	and	and	CC
cord-350836-1enteev7	84	25	3	3	CD
cord-350836-1enteev7	84	26	′	′	CD
cord-350836-1enteev7	84	27	ends	end	NNS
cord-350836-1enteev7	84	28	of	of	IN
cord-350836-1enteev7	84	29	the	the	DT
cord-350836-1enteev7	84	30	dsRNA	dsrna	NN
cord-350836-1enteev7	84	31	(	(	-LRB-
cord-350836-1enteev7	84	32	61	61	CD
cord-350836-1enteev7	84	33	)	)	-RRB-
cord-350836-1enteev7	84	34	,	,	,
cord-350836-1enteev7	84	35	whereas	whereas	IN
cord-350836-1enteev7	84	36	the	the	DT
cord-350836-1enteev7	84	37	MDA5	MDA5	NNP
cord-350836-1enteev7	84	38	Hel	Hel	NNP
cord-350836-1enteev7	84	39	-	-	HYPH
cord-350836-1enteev7	84	40	CTD	CTD	NNP
cord-350836-1enteev7	84	41	domain	domain	NN
cord-350836-1enteev7	84	42	runs	run	VBZ
cord-350836-1enteev7	84	43	parallel	parallel	JJ
cord-350836-1enteev7	84	44	to	to	IN
cord-350836-1enteev7	84	45	the	the	DT
cord-350836-1enteev7	84	46	RNA	RNA	NNP
cord-350836-1enteev7	84	47	strand	strand	NN
cord-350836-1enteev7	84	48	(	(	-LRB-
cord-350836-1enteev7	84	49	Figures	figure	NNS
cord-350836-1enteev7	84	50	3C	3c	NN
cord-350836-1enteev7	84	51	,	,	,
cord-350836-1enteev7	84	52	D	D	NNP
cord-350836-1enteev7	84	53	)	)	-RRB-
cord-350836-1enteev7	84	54	.	.	.
cord-350836-1enteev7	85	1	The	the	DT
cord-350836-1enteev7	85	2	series	series	NN
cord-350836-1enteev7	85	3	of	of	IN
cord-350836-1enteev7	85	4	steps	step	NNS
cord-350836-1enteev7	85	5	required	require	VBN
cord-350836-1enteev7	85	6	for	for	IN
cord-350836-1enteev7	85	7	RIG	rig	NN
cord-350836-1enteev7	85	8	-	-	:
cord-350836-1enteev7	85	9	I	I	NNP
cord-350836-1enteev7	85	10	and	and	CC
cord-350836-1enteev7	85	11	MDA5	MDA5	NNP
cord-350836-1enteev7	85	12	activation	activation	NN
cord-350836-1enteev7	85	13	have	have	VBP
cord-350836-1enteev7	85	14	been	be	VBN
cord-350836-1enteev7	85	15	described	describe	VBN
cord-350836-1enteev7	85	16	in	in	IN
cord-350836-1enteev7	85	17	depth	depth	NN
cord-350836-1enteev7	85	18	elsewhere	elsewhere	RB
cord-350836-1enteev7	85	19	(	(	-LRB-
cord-350836-1enteev7	85	20	80	80	CD
cord-350836-1enteev7	85	21	)	)	-RRB-
cord-350836-1enteev7	85	22	(	(	-LRB-
cord-350836-1enteev7	85	23	81	81	CD
cord-350836-1enteev7	85	24	)	)	-RRB-
cord-350836-1enteev7	86	1	(	(	-LRB-
cord-350836-1enteev7	86	2	82	82	CD
cord-350836-1enteev7	86	3	)	)	-RRB-
cord-350836-1enteev7	87	1	(	(	-LRB-
cord-350836-1enteev7	87	2	83	83	CD
cord-350836-1enteev7	87	3	)	)	-RRB-
cord-350836-1enteev7	88	1	(	(	-LRB-
cord-350836-1enteev7	88	2	84	84	CD
cord-350836-1enteev7	88	3	)	)	-RRB-
cord-350836-1enteev7	88	4	.	.	.
cord-350836-1enteev7	89	1	Briefly	Briefly	NNP
cord-350836-1enteev7	89	2	summarized	summarize	VBD
cord-350836-1enteev7	89	3	,	,	,
cord-350836-1enteev7	89	4	these	these	DT
cord-350836-1enteev7	89	5	proteins	protein	NNS
cord-350836-1enteev7	89	6	endogenously	endogenously	RB
cord-350836-1enteev7	89	7	exist	exist	VBP
cord-350836-1enteev7	89	8	in	in	IN
cord-350836-1enteev7	89	9	the	the	DT
cord-350836-1enteev7	89	10	cytoplasm	cytoplasm	NN
cord-350836-1enteev7	89	11	of	of	IN
cord-350836-1enteev7	89	12	the	the	DT
cord-350836-1enteev7	89	13	cell	cell	NN
cord-350836-1enteev7	89	14	in	in	IN
cord-350836-1enteev7	89	15	a	a	DT
cord-350836-1enteev7	89	16	phosphorylated	phosphorylated	JJ
cord-350836-1enteev7	89	17	and	and	CC
cord-350836-1enteev7	89	18	inactivated	inactivate	VBN
cord-350836-1enteev7	89	19	conformation	conformation	NN
cord-350836-1enteev7	89	20	when	when	WRB
cord-350836-1enteev7	89	21	they	-PRON-	PRP
cord-350836-1enteev7	89	22	are	be	VBP
cord-350836-1enteev7	89	23	not	not	RB
cord-350836-1enteev7	89	24	activated	activate	VBN
cord-350836-1enteev7	89	25	by	by	IN
cord-350836-1enteev7	89	26	PAMP	PAMP	NNP
cord-350836-1enteev7	89	27	(	(	-LRB-
cord-350836-1enteev7	89	28	dsRNA	dsrna	NN
cord-350836-1enteev7	89	29	)	)	-RRB-
cord-350836-1enteev7	89	30	(	(	-LRB-
cord-350836-1enteev7	89	31	85	85	CD
cord-350836-1enteev7	89	32	)	)	-RRB-
cord-350836-1enteev7	89	33	(	(	-LRB-
cord-350836-1enteev7	89	34	86	86	CD
cord-350836-1enteev7	89	35	)	)	-RRB-
cord-350836-1enteev7	89	36	(	(	-LRB-
cord-350836-1enteev7	89	37	87	87	CD
cord-350836-1enteev7	89	38	)	)	-RRB-
cord-350836-1enteev7	90	1	(	(	-LRB-
cord-350836-1enteev7	90	2	Figures	figure	NNS
cord-350836-1enteev7	90	3	4A	4a	CD
cord-350836-1enteev7	90	4	,	,	,
cord-350836-1enteev7	90	5	F	F	NNP
cord-350836-1enteev7	90	6	)	)	-RRB-
cord-350836-1enteev7	90	7	.	.	.
cord-350836-1enteev7	91	1	Phosphorylation	Phosphorylation	NNP
cord-350836-1enteev7	91	2	is	be	VBZ
cord-350836-1enteev7	91	3	mediated	mediate	VBN
cord-350836-1enteev7	91	4	at	at	IN
cord-350836-1enteev7	91	5	the	the	DT
cord-350836-1enteev7	91	6	N	n	CD
cord-350836-1enteev7	91	7	terminal	terminal	NN
cord-350836-1enteev7	91	8	CARD	card	NN
cord-350836-1enteev7	91	9	domains	domain	NNS
cord-350836-1enteev7	91	10	(	(	-LRB-
cord-350836-1enteev7	91	11	S8	S8	NNP
cord-350836-1enteev7	91	12	and	and	CC
cord-350836-1enteev7	91	13	T170	T170	NNP
cord-350836-1enteev7	91	14	)	)	-RRB-
cord-350836-1enteev7	91	15	of	of	IN
cord-350836-1enteev7	91	16	RIG	rig	NN
cord-350836-1enteev7	91	17	-	-	:
cord-350836-1enteev7	91	18	I	i	NN
cord-350836-1enteev7	91	19	by	by	IN
cord-350836-1enteev7	91	20	PKC	PKC	NNP
cord-350836-1enteev7	91	21	-	-	HYPH
cord-350836-1enteev7	91	22	α	α	NNP
cord-350836-1enteev7	91	23	/	/	SYM
cord-350836-1enteev7	91	24	β	β	NN
cord-350836-1enteev7	91	25	(	(	-LRB-
cord-350836-1enteev7	91	26	88	88	CD
cord-350836-1enteev7	91	27	,	,	,
cord-350836-1enteev7	91	28	89	89	CD
cord-350836-1enteev7	91	29	)	)	-RRB-
cord-350836-1enteev7	91	30	and	and	CC
cord-350836-1enteev7	91	31	at	at	IN
cord-350836-1enteev7	91	32	the	the	DT
cord-350836-1enteev7	91	33	C	C	NNP
cord-350836-1enteev7	91	34	terminal	terminal	NN
cord-350836-1enteev7	91	35	RNA	RNA	NNP
cord-350836-1enteev7	91	36	interaction	interaction	NN
cord-350836-1enteev7	91	37	domain	domain	NN
cord-350836-1enteev7	91	38	(	(	-LRB-
cord-350836-1enteev7	91	39	S854	S854	NNP
cord-350836-1enteev7	91	40	,	,	,
cord-350836-1enteev7	91	41	S855	s855	UH
cord-350836-1enteev7	91	42	,	,	,
cord-350836-1enteev7	91	43	and	and	CC
cord-350836-1enteev7	91	44	T770	T770	NNP
cord-350836-1enteev7	91	45	)	)	-RRB-
cord-350836-1enteev7	91	46	by	by	IN
cord-350836-1enteev7	91	47	CKβ	CKβ	NNS
cord-350836-1enteev7	91	48	(	(	-LRB-
cord-350836-1enteev7	91	49	90	90	CD
cord-350836-1enteev7	91	50	)	)	-RRB-
cord-350836-1enteev7	91	51	.	.	.
cord-350836-1enteev7	92	1	On	on	IN
cord-350836-1enteev7	92	2	the	the	DT
cord-350836-1enteev7	92	3	other	other	JJ
cord-350836-1enteev7	92	4	hand	hand	NN
cord-350836-1enteev7	92	5	,	,	,
cord-350836-1enteev7	92	6	MDA5	MDA5	NNP
cord-350836-1enteev7	92	7	is	be	VBZ
cord-350836-1enteev7	92	8	phosphorylated	phosphorylate	VBN
cord-350836-1enteev7	92	9	at	at	IN
cord-350836-1enteev7	92	10	S828	S828	NNP
cord-350836-1enteev7	92	11	by	by	IN
cord-350836-1enteev7	92	12	RIOK3	riok3	JJ
cord-350836-1enteev7	92	13	(	(	-LRB-
cord-350836-1enteev7	92	14	91	91	CD
cord-350836-1enteev7	92	15	)	)	-RRB-
cord-350836-1enteev7	92	16	as	as	RB
cord-350836-1enteev7	92	17	well	well	RB
cord-350836-1enteev7	92	18	as	as	IN
cord-350836-1enteev7	92	19	by	by	IN
cord-350836-1enteev7	92	20	other	other	JJ
cord-350836-1enteev7	92	21	yet	yet	CC
cord-350836-1enteev7	92	22	unknown	unknown	JJ
cord-350836-1enteev7	92	23	kinases	kinase	NNS
cord-350836-1enteev7	92	24	(	(	-LRB-
cord-350836-1enteev7	92	25	92	92	CD
cord-350836-1enteev7	92	26	,	,	,
cord-350836-1enteev7	92	27	93	93	CD
cord-350836-1enteev7	92	28	)	)	-RRB-
cord-350836-1enteev7	92	29	.	.	.
cord-350836-1enteev7	93	1	RIG	rig	NN
cord-350836-1enteev7	93	2	-	-	:
cord-350836-1enteev7	93	3	I	-PRON-	PRP
cord-350836-1enteev7	93	4	is	be	VBZ
cord-350836-1enteev7	93	5	also	also	RB
cord-350836-1enteev7	93	6	acetylated	acetylate	VBN
cord-350836-1enteev7	93	7	at	at	IN
cord-350836-1enteev7	93	8	K909	k909	CD
cord-350836-1enteev7	93	9	in	in	IN
cord-350836-1enteev7	93	10	its	-PRON-	PRP$
cord-350836-1enteev7	93	11	C	C	NNP
cord-350836-1enteev7	93	12	terminal	terminal	NN
cord-350836-1enteev7	93	13	domain	domain	NN
cord-350836-1enteev7	93	14	that	that	WDT
cord-350836-1enteev7	93	15	requires	require	VBZ
cord-350836-1enteev7	93	16	deacetylation	deacetylation	NN
cord-350836-1enteev7	93	17	by	by	IN
cord-350836-1enteev7	93	18	HDAC6	HDAC6	NNS
cord-350836-1enteev7	93	19	to	to	TO
cord-350836-1enteev7	93	20	be	be	VB
cord-350836-1enteev7	93	21	able	able	JJ
cord-350836-1enteev7	93	22	to	to	TO
cord-350836-1enteev7	93	23	recognize	recognize	VB
cord-350836-1enteev7	93	24	RNA	RNA	NNP
cord-350836-1enteev7	93	25	in	in	IN
cord-350836-1enteev7	93	26	its	-PRON-	PRP$
cord-350836-1enteev7	93	27	activated	activate	VBN
cord-350836-1enteev7	93	28	form	form	NN
cord-350836-1enteev7	93	29	(	(	-LRB-
cord-350836-1enteev7	93	30	94	94	CD
cord-350836-1enteev7	93	31	)	)	-RRB-
cord-350836-1enteev7	93	32	.	.	.
cord-350836-1enteev7	94	1	Upon	upon	IN
cord-350836-1enteev7	94	2	recognition	recognition	NN
cord-350836-1enteev7	94	3	of	of	IN
cord-350836-1enteev7	94	4	PAMP	PAMP	NNP
cord-350836-1enteev7	94	5	(	(	-LRB-
cord-350836-1enteev7	94	6	dsRNA	dsrna	NN
cord-350836-1enteev7	94	7	)	)	-RRB-
cord-350836-1enteev7	94	8	,	,	,
cord-350836-1enteev7	94	9	RIG	rig	NN
cord-350836-1enteev7	94	10	-	-	:
cord-350836-1enteev7	94	11	I	-PRON-	PRP
cord-350836-1enteev7	94	12	unfolds	unfold	VBZ
cord-350836-1enteev7	94	13	into	into	IN
cord-350836-1enteev7	94	14	an	an	DT
cord-350836-1enteev7	94	15	open	open	JJ
cord-350836-1enteev7	94	16	and	and	CC
cord-350836-1enteev7	94	17	activated	activate	VBN
cord-350836-1enteev7	94	18	state	state	NN
cord-350836-1enteev7	94	19	that	that	WDT
cord-350836-1enteev7	94	20	is	be	VBZ
cord-350836-1enteev7	94	21	mediated	mediate	VBN
cord-350836-1enteev7	94	22	by	by	IN
cord-350836-1enteev7	94	23	the	the	DT
cord-350836-1enteev7	94	24	flexible	flexible	JJ
cord-350836-1enteev7	94	25	hinge	hinge	NN
cord-350836-1enteev7	94	26	regions	region	NNS
cord-350836-1enteev7	94	27	between	between	IN
cord-350836-1enteev7	94	28	the	the	DT
cord-350836-1enteev7	94	29	CARD	card	NN
cord-350836-1enteev7	94	30	domains	domain	NNS
cord-350836-1enteev7	94	31	and	and	CC
cord-350836-1enteev7	94	32	the	the	DT
cord-350836-1enteev7	94	33	helicase	helicase	NN
cord-350836-1enteev7	94	34	domain	domain	NN
cord-350836-1enteev7	94	35	,	,	,
cord-350836-1enteev7	94	36	and	and	CC
cord-350836-1enteev7	94	37	between	between	IN
cord-350836-1enteev7	94	38	the	the	DT
cord-350836-1enteev7	94	39	helicase	helicase	NN
cord-350836-1enteev7	94	40	and	and	CC
cord-350836-1enteev7	94	41	the	the	DT
cord-350836-1enteev7	94	42	C	C	NNP
cord-350836-1enteev7	94	43	terminal	terminal	NN
cord-350836-1enteev7	94	44	domain	domain	NN
cord-350836-1enteev7	94	45	(	(	-LRB-
cord-350836-1enteev7	94	46	64	64	CD
cord-350836-1enteev7	94	47	,	,	,
cord-350836-1enteev7	94	48	87	87	CD
cord-350836-1enteev7	94	49	,	,	,
cord-350836-1enteev7	94	50	(	(	-LRB-
cord-350836-1enteev7	94	51	95	95	CD
cord-350836-1enteev7	94	52	)	)	-RRB-
cord-350836-1enteev7	94	53	(	(	-LRB-
cord-350836-1enteev7	94	54	96	96	CD
cord-350836-1enteev7	94	55	)	)	-RRB-
cord-350836-1enteev7	94	56	(	(	-LRB-
cord-350836-1enteev7	94	57	97	97	CD
cord-350836-1enteev7	94	58	)	)	-RRB-
cord-350836-1enteev7	94	59	(	(	-LRB-
cord-350836-1enteev7	94	60	98	98	CD
cord-350836-1enteev7	94	61	)	)	-RRB-
cord-350836-1enteev7	94	62	(	(	-LRB-
cord-350836-1enteev7	94	63	Figure	figure	NN
cord-350836-1enteev7	94	64	4B	4b	NN
cord-350836-1enteev7	94	65	)	)	-RRB-
cord-350836-1enteev7	94	66	.	.	.
cord-350836-1enteev7	95	1	On	on	IN
cord-350836-1enteev7	95	2	the	the	DT
cord-350836-1enteev7	95	3	contrary	contrary	NN
cord-350836-1enteev7	95	4	,	,	,
cord-350836-1enteev7	95	5	there	there	EX
cord-350836-1enteev7	95	6	is	be	VBZ
cord-350836-1enteev7	95	7	evidence	evidence	NN
cord-350836-1enteev7	95	8	to	to	TO
cord-350836-1enteev7	95	9	suggest	suggest	VB
cord-350836-1enteev7	95	10	that	that	IN
cord-350836-1enteev7	95	11	MDA5	MDA5	NNP
cord-350836-1enteev7	95	12	has	have	VBZ
cord-350836-1enteev7	95	13	a	a	DT
cord-350836-1enteev7	95	14	more	more	RBR
cord-350836-1enteev7	95	15	dynamic	dynamic	JJ
cord-350836-1enteev7	95	16	structure	structure	NN
cord-350836-1enteev7	95	17	(	(	-LRB-
cord-350836-1enteev7	95	18	99	99	CD
cord-350836-1enteev7	95	19	)	)	-RRB-
cord-350836-1enteev7	95	20	.	.	.
cord-350836-1enteev7	96	1	Unlike	unlike	IN
cord-350836-1enteev7	96	2	a	a	DT
cord-350836-1enteev7	96	3	model	model	NN
cord-350836-1enteev7	96	4	of	of	IN
cord-350836-1enteev7	96	5	RIG	rig	NN
cord-350836-1enteev7	96	6	-	-	:
cord-350836-1enteev7	96	7	I	-PRON-	PRP
cord-350836-1enteev7	96	8	activation	activation	NN
cord-350836-1enteev7	96	9	described	describe	VBN
cord-350836-1enteev7	96	10	above	above	RB
cord-350836-1enteev7	96	11	,	,	,
cord-350836-1enteev7	96	12	MDA5	MDA5	NNP
cord-350836-1enteev7	96	13	exists	exist	VBZ
cord-350836-1enteev7	96	14	in	in	IN
cord-350836-1enteev7	96	15	a	a	DT
cord-350836-1enteev7	96	16	conformational	conformational	JJ
cord-350836-1enteev7	96	17	equilibrium	equilibrium	NN
cord-350836-1enteev7	96	18	between	between	IN
cord-350836-1enteev7	96	19	close	close	JJ
cord-350836-1enteev7	96	20	and	and	CC
cord-350836-1enteev7	96	21	open	open	JJ
cord-350836-1enteev7	96	22	forms	form	NNS
cord-350836-1enteev7	96	23	,	,	,
cord-350836-1enteev7	96	24	with	with	IN
cord-350836-1enteev7	96	25	close	close	JJ
cord-350836-1enteev7	96	26	forms	form	NNS
cord-350836-1enteev7	96	27	favored	favor	VBN
cord-350836-1enteev7	96	28	in	in	IN
cord-350836-1enteev7	96	29	the	the	DT
cord-350836-1enteev7	96	30	dsRNA	dsrna	NN
cord-350836-1enteev7	96	31	unliganded	unligande	VBN
cord-350836-1enteev7	96	32	state	state	NN
cord-350836-1enteev7	96	33	.	.	.
cord-350836-1enteev7	97	1	While	while	IN
cord-350836-1enteev7	97	2	not	not	RB
cord-350836-1enteev7	97	3	yet	yet	RB
cord-350836-1enteev7	97	4	formally	formally	RB
cord-350836-1enteev7	97	5	demonstrated	demonstrate	VBN
cord-350836-1enteev7	97	6	,	,	,
cord-350836-1enteev7	97	7	it	-PRON-	PRP
cord-350836-1enteev7	97	8	is	be	VBZ
cord-350836-1enteev7	97	9	possible	possible	JJ
cord-350836-1enteev7	97	10	that	that	IN
cord-350836-1enteev7	97	11	MDA5	MDA5	NNP
cord-350836-1enteev7	97	12	may	may	MD
cord-350836-1enteev7	97	13	be	be	VB
cord-350836-1enteev7	97	14	inhibited	inhibit	VBN
cord-350836-1enteev7	97	15	in	in	IN
cord-350836-1enteev7	97	16	the	the	DT
cord-350836-1enteev7	97	17	absence	absence	NN
cord-350836-1enteev7	97	18	of	of	IN
cord-350836-1enteev7	97	19	the	the	DT
cord-350836-1enteev7	97	20	dsRNA	dsrna	NN
cord-350836-1enteev7	97	21	ligand	ligand	NN
cord-350836-1enteev7	97	22	by	by	IN
cord-350836-1enteev7	97	23	its	-PRON-	PRP$
cord-350836-1enteev7	97	24	structural	structural	JJ
cord-350836-1enteev7	97	25	dynamics	dynamic	NNS
cord-350836-1enteev7	97	26	,	,	,
cord-350836-1enteev7	97	27	which	which	WDT
cord-350836-1enteev7	97	28	may	may	MD
cord-350836-1enteev7	97	29	prevent	prevent	VB
cord-350836-1enteev7	97	30	strong	strong	JJ
cord-350836-1enteev7	97	31	protein	protein	NN
cord-350836-1enteev7	97	32	-	-	HYPH
cord-350836-1enteev7	97	33	protein	protein	NN
cord-350836-1enteev7	97	34	interactions	interaction	NNS
cord-350836-1enteev7	97	35	(	(	-LRB-
cord-350836-1enteev7	97	36	Figure	figure	NN
cord-350836-1enteev7	97	37	4F	4f	CD
cord-350836-1enteev7	97	38	)	)	-RRB-
cord-350836-1enteev7	97	39	.	.	.
cord-350836-1enteev7	98	1	However	however	RB
cord-350836-1enteev7	98	2	,	,	,
cord-350836-1enteev7	98	3	upon	upon	IN
cord-350836-1enteev7	98	4	binding	bind	VBG
cord-350836-1enteev7	98	5	to	to	IN
cord-350836-1enteev7	98	6	dsRNA	dsrna	NN
cord-350836-1enteev7	98	7	ligand	ligand	NN
cord-350836-1enteev7	98	8	,	,	,
cord-350836-1enteev7	98	9	MDA5	MDA5	NNP
cord-350836-1enteev7	98	10	adopts	adopt	VBZ
cord-350836-1enteev7	98	11	an	an	DT
cord-350836-1enteev7	98	12	open	open	JJ
cord-350836-1enteev7	98	13	and	and	CC
cord-350836-1enteev7	98	14	activated	activate	VBN
cord-350836-1enteev7	98	15	form	form	NN
cord-350836-1enteev7	98	16	,	,	,
cord-350836-1enteev7	98	17	which	which	WDT
cord-350836-1enteev7	98	18	is	be	VBZ
cord-350836-1enteev7	98	19	perhaps	perhaps	RB
cord-350836-1enteev7	98	20	more	more	RBR
cord-350836-1enteev7	98	21	conducive	conducive	JJ
cord-350836-1enteev7	98	22	for	for	IN
cord-350836-1enteev7	98	23	protein	protein	NN
cord-350836-1enteev7	98	24	-	-	HYPH
cord-350836-1enteev7	98	25	protein	protein	NN
cord-350836-1enteev7	98	26	interactions	interaction	NNS
cord-350836-1enteev7	98	27	(	(	-LRB-
cord-350836-1enteev7	98	28	Figures	figure	NNS
cord-350836-1enteev7	98	29	4G	4g	NN
cord-350836-1enteev7	98	30	,	,	,
cord-350836-1enteev7	98	31	H	H	NNP
cord-350836-1enteev7	98	32	)	)	-RRB-
cord-350836-1enteev7	98	33	.	.	.
cord-350836-1enteev7	99	1	Once	once	IN
cord-350836-1enteev7	99	2	the	the	DT
cord-350836-1enteev7	99	3	C	C	NNP
cord-350836-1enteev7	99	4	terminal	terminal	NN
cord-350836-1enteev7	99	5	domains	domain	NNS
cord-350836-1enteev7	99	6	have	have	VBP
cord-350836-1enteev7	99	7	been	be	VBN
cord-350836-1enteev7	99	8	de	de	VBN
cord-350836-1enteev7	99	9	-	-	VBN
cord-350836-1enteev7	99	10	phosphorylated	phosphorylated	JJ
cord-350836-1enteev7	99	11	,	,	,
cord-350836-1enteev7	99	12	the	the	DT
cord-350836-1enteev7	99	13	E3	e3	NN
cord-350836-1enteev7	99	14	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	99	15	ligase	ligase	NN
cord-350836-1enteev7	99	16	Riplet	Riplet	NNP
cord-350836-1enteev7	99	17	attaches	attach	VBZ
cord-350836-1enteev7	99	18	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	99	19	peptides	peptide	NNS
cord-350836-1enteev7	99	20	onto	onto	IN
cord-350836-1enteev7	99	21	the	the	DT
cord-350836-1enteev7	99	22	C	C	NNP
cord-350836-1enteev7	99	23	terminal	terminal	NN
cord-350836-1enteev7	99	24	domain	domain	NN
cord-350836-1enteev7	99	25	of	of	IN
cord-350836-1enteev7	99	26	RIG	rig	NN
cord-350836-1enteev7	100	1	-I	-i	WDT
cord-350836-1enteev7	100	2	at	at	IN
cord-350836-1enteev7	100	3	residues	residue	NNS
cord-350836-1enteev7	100	4	K849	k849	VBP
cord-350836-1enteev7	100	5	and	and	CC
cord-350836-1enteev7	100	6	K851	K851	NNP
cord-350836-1enteev7	100	7	(	(	-LRB-
cord-350836-1enteev7	100	8	100	100	CD
cord-350836-1enteev7	100	9	,	,	,
cord-350836-1enteev7	100	10	101	101	CD
cord-350836-1enteev7	100	11	)	)	-RRB-
cord-350836-1enteev7	100	12	.	.	.
cord-350836-1enteev7	101	1	It	-PRON-	PRP
cord-350836-1enteev7	101	2	was	be	VBD
cord-350836-1enteev7	101	3	previously	previously	RB
cord-350836-1enteev7	101	4	shown	show	VBN
cord-350836-1enteev7	101	5	that	that	IN
cord-350836-1enteev7	101	6	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	101	7	by	by	IN
cord-350836-1enteev7	101	8	Riplet	Riplet	NNP
cord-350836-1enteev7	101	9	was	be	VBD
cord-350836-1enteev7	101	10	necessary	necessary	JJ
cord-350836-1enteev7	101	11	for	for	IN
cord-350836-1enteev7	101	12	opening	open	VBG
cord-350836-1enteev7	101	13	RIG	rig	NN
cord-350836-1enteev7	101	14	-	-	:
cord-350836-1enteev7	101	15	I	-PRON-	PRP
cord-350836-1enteev7	101	16	and	and	CC
cord-350836-1enteev7	101	17	for	for	IN
cord-350836-1enteev7	101	18	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	101	19	of	of	IN
cord-350836-1enteev7	101	20	the	the	DT
cord-350836-1enteev7	101	21	CARD	card	NN
cord-350836-1enteev7	101	22	domain	domain	NN
cord-350836-1enteev7	101	23	(	(	-LRB-
cord-350836-1enteev7	101	24	102	102	CD
cord-350836-1enteev7	101	25	)	)	-RRB-
cord-350836-1enteev7	101	26	.	.	.
cord-350836-1enteev7	102	1	However	however	RB
cord-350836-1enteev7	102	2	,	,	,
cord-350836-1enteev7	102	3	in	in	IN
cord-350836-1enteev7	102	4	-	-	HYPH
cord-350836-1enteev7	102	5	situ	situ	JJ
cord-350836-1enteev7	102	6	studies	study	NNS
cord-350836-1enteev7	102	7	found	find	VBD
cord-350836-1enteev7	102	8	that	that	IN
cord-350836-1enteev7	102	9	dsRNA	dsrna	NN
cord-350836-1enteev7	102	10	was	be	VBD
cord-350836-1enteev7	102	11	sufficient	sufficient	JJ
cord-350836-1enteev7	102	12	to	to	TO
cord-350836-1enteev7	102	13	weaken	weaken	VB
cord-350836-1enteev7	102	14	the	the	DT
cord-350836-1enteev7	102	15	interaction	interaction	NN
cord-350836-1enteev7	102	16	between	between	IN
cord-350836-1enteev7	102	17	purified	purify	VBN
cord-350836-1enteev7	102	18	RIG	rig	NN
cord-350836-1enteev7	102	19	-	-	:
cord-350836-1enteev7	102	20	I	I	NNP
cord-350836-1enteev7	102	21	C	C	NNP
cord-350836-1enteev7	102	22	terminal	terminal	NN
cord-350836-1enteev7	102	23	domain	domain	NN
cord-350836-1enteev7	102	24	and	and	CC
cord-350836-1enteev7	102	25	RIG	rig	NN
cord-350836-1enteev7	102	26	-	-	HYPH
cord-350836-1enteev7	102	27	I	i	NN
cord-350836-1enteev7	102	28	CARD	card	NN
cord-350836-1enteev7	102	29	domains	domain	NNS
cord-350836-1enteev7	102	30	(	(	-LRB-
cord-350836-1enteev7	102	31	86	86	CD
cord-350836-1enteev7	102	32	)	)	-RRB-
cord-350836-1enteev7	102	33	and	and	CC
cord-350836-1enteev7	102	34	that	that	IN
cord-350836-1enteev7	102	35	dsRNA	dsrna	NN
cord-350836-1enteev7	102	36	was	be	VBD
cord-350836-1enteev7	102	37	necessary	necessary	JJ
cord-350836-1enteev7	102	38	for	for	IN
cord-350836-1enteev7	102	39	Riplet	Riplet	NNP
cord-350836-1enteev7	102	40	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	102	41	(	(	-LRB-
cord-350836-1enteev7	102	42	103	103	CD
cord-350836-1enteev7	102	43	)	)	-RRB-
cord-350836-1enteev7	102	44	,	,	,
cord-350836-1enteev7	102	45	calling	call	VBG
cord-350836-1enteev7	102	46	into	into	IN
cord-350836-1enteev7	102	47	question	question	NN
cord-350836-1enteev7	102	48	the	the	DT
cord-350836-1enteev7	102	49	sequential	sequential	JJ
cord-350836-1enteev7	102	50	order	order	NN
cord-350836-1enteev7	102	51	for	for	IN
cord-350836-1enteev7	102	52	RIG	rig	NN
cord-350836-1enteev7	102	53	-	-	:
cord-350836-1enteev7	102	54	I	-PRON-	PRP
cord-350836-1enteev7	102	55	activation	activation	NN
cord-350836-1enteev7	102	56	(	(	-LRB-
cord-350836-1enteev7	102	57	Figure	figure	NN
cord-350836-1enteev7	102	58	4C	4c	CD
cord-350836-1enteev7	102	59	)	)	-RRB-
cord-350836-1enteev7	102	60	.	.	.
cord-350836-1enteev7	103	1	Following	follow	VBG
cord-350836-1enteev7	103	2	de	de	NN
cord-350836-1enteev7	103	3	-	-	NN
cord-350836-1enteev7	103	4	phosphorylation	phosphorylation	NN
cord-350836-1enteev7	103	5	of	of	IN
cord-350836-1enteev7	103	6	the	the	DT
cord-350836-1enteev7	103	7	CARD	card	NN
cord-350836-1enteev7	103	8	domain	domain	NN
cord-350836-1enteev7	103	9	by	by	IN
cord-350836-1enteev7	103	10	the	the	DT
cord-350836-1enteev7	103	11	phosphatase	phosphatase	NN
cord-350836-1enteev7	103	12	PP1-α	PP1-α	NNP
cord-350836-1enteev7	103	13	/	/	SYM
cord-350836-1enteev7	103	14	γ	γ	NNP
cord-350836-1enteev7	103	15	(	(	-LRB-
cord-350836-1enteev7	103	16	92	92	CD
cord-350836-1enteev7	103	17	)	)	-RRB-
cord-350836-1enteev7	103	18	,	,	,
cord-350836-1enteev7	103	19	this	this	DT
cord-350836-1enteev7	103	20	domain	domain	NN
cord-350836-1enteev7	103	21	is	be	VBZ
cord-350836-1enteev7	103	22	polyubiquinated	polyubiquinate	VBN
cord-350836-1enteev7	103	23	at	at	IN
cord-350836-1enteev7	103	24	K172	K172	NNP
cord-350836-1enteev7	103	25	by	by	IN
cord-350836-1enteev7	103	26	the	the	DT
cord-350836-1enteev7	103	27	E3	E3	NNP
cord-350836-1enteev7	103	28	TRIM25	TRIM25	NNP
cord-350836-1enteev7	103	29	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	103	30	ligase	ligase	NN
cord-350836-1enteev7	103	31	(	(	-LRB-
cord-350836-1enteev7	103	32	104	104	CD
cord-350836-1enteev7	103	33	)	)	-RRB-
cord-350836-1enteev7	103	34	,	,	,
cord-350836-1enteev7	103	35	which	which	WDT
cord-350836-1enteev7	103	36	itself	-PRON-	PRP
cord-350836-1enteev7	103	37	is	be	VBZ
cord-350836-1enteev7	103	38	activated	activate	VBN
cord-350836-1enteev7	103	39	by	by	IN
cord-350836-1enteev7	103	40	Caspase	Caspase	NNP
cord-350836-1enteev7	103	41	12	12	CD
cord-350836-1enteev7	103	42	(	(	-LRB-
cord-350836-1enteev7	103	43	105	105	CD
cord-350836-1enteev7	103	44	)	)	-RRB-
cord-350836-1enteev7	103	45	(	(	-LRB-
cord-350836-1enteev7	103	46	Figure	figure	NN
cord-350836-1enteev7	103	47	4D	4d	CD
cord-350836-1enteev7	103	48	)	)	-RRB-
cord-350836-1enteev7	103	49	.	.	.
cord-350836-1enteev7	104	1	TRIM25	trim25	NN
cord-350836-1enteev7	104	2	interacting	interact	VBG
cord-350836-1enteev7	104	3	with	with	IN
cord-350836-1enteev7	104	4	RIG	rig	NN
cord-350836-1enteev7	104	5	-	-	:
cord-350836-1enteev7	104	6	I	-PRON-	PRP
cord-350836-1enteev7	104	7	may	may	MD
cord-350836-1enteev7	104	8	also	also	RB
cord-350836-1enteev7	104	9	be	be	VB
cord-350836-1enteev7	104	10	mediated	mediate	VBN
cord-350836-1enteev7	104	11	by	by	IN
cord-350836-1enteev7	104	12	their	-PRON-	PRP$
cord-350836-1enteev7	104	13	mutual	mutual	JJ
cord-350836-1enteev7	104	14	interactions	interaction	NNS
cord-350836-1enteev7	104	15	with	with	IN
cord-350836-1enteev7	104	16	certain	certain	JJ
cord-350836-1enteev7	104	17	host	host	NN
cord-350836-1enteev7	104	18	long	long	JJ
cord-350836-1enteev7	104	19	non	non	JJ
cord-350836-1enteev7	104	20	-	-	JJ
cord-350836-1enteev7	104	21	coding	coding	JJ
cord-350836-1enteev7	104	22	RNA	RNA	NNP
cord-350836-1enteev7	104	23	(	(	-LRB-
cord-350836-1enteev7	104	24	lncRNA	lncRNA	NNP
cord-350836-1enteev7	104	25	)	)	-RRB-
cord-350836-1enteev7	104	26	,	,	,
cord-350836-1enteev7	104	27	which	which	WDT
cord-350836-1enteev7	104	28	occurs	occur	VBZ
cord-350836-1enteev7	104	29	outside	outside	RB
cord-350836-1enteev7	104	30	of	of	IN
cord-350836-1enteev7	104	31	the	the	DT
cord-350836-1enteev7	104	32	dsRNA	dsrna	NN
cord-350836-1enteev7	104	33	recognizing	recognize	VBG
cord-350836-1enteev7	104	34	domain	domain	NN
cord-350836-1enteev7	104	35	in	in	IN
cord-350836-1enteev7	104	36	the	the	DT
cord-350836-1enteev7	104	37	CTD	CTD	NNP
cord-350836-1enteev7	104	38	of	of	IN
cord-350836-1enteev7	104	39	RIG	rig	NN
cord-350836-1enteev7	104	40	-	-	:
cord-350836-1enteev7	104	41	I	i	NN
cord-350836-1enteev7	104	42	(	(	-LRB-
cord-350836-1enteev7	104	43	106	106	CD
cord-350836-1enteev7	104	44	)	)	-RRB-
cord-350836-1enteev7	104	45	.	.	.
cord-350836-1enteev7	105	1	A	a	DT
cord-350836-1enteev7	105	2	recent	recent	JJ
cord-350836-1enteev7	105	3	study	study	NN
cord-350836-1enteev7	105	4	showed	show	VBD
cord-350836-1enteev7	105	5	that	that	IN
cord-350836-1enteev7	105	6	Riplet	Riplet	NNP
cord-350836-1enteev7	105	7	rather	rather	RB
cord-350836-1enteev7	105	8	than	than	IN
cord-350836-1enteev7	105	9	TRIM25	TRIM25	NNP
cord-350836-1enteev7	105	10	was	be	VBD
cord-350836-1enteev7	105	11	primarily	primarily	RB
cord-350836-1enteev7	105	12	responsible	responsible	JJ
cord-350836-1enteev7	105	13	for	for	IN
cord-350836-1enteev7	105	14	ubiquitinating	ubiquitinate	VBG
cord-350836-1enteev7	105	15	and	and	CC
cord-350836-1enteev7	105	16	activating	activate	VBG
cord-350836-1enteev7	105	17	RIG-	RIG-	NNP
cord-350836-1enteev7	106	1	I	-PRON-	PRP
cord-350836-1enteev7	106	2	(	(	-LRB-
cord-350836-1enteev7	106	3	103	103	CD
cord-350836-1enteev7	106	4	)	)	-RRB-
cord-350836-1enteev7	106	5	.	.	.
cord-350836-1enteev7	107	1	However	however	RB
cord-350836-1enteev7	107	2	,	,	,
cord-350836-1enteev7	107	3	there	there	EX
cord-350836-1enteev7	107	4	are	be	VBP
cord-350836-1enteev7	107	5	several	several	JJ
cord-350836-1enteev7	107	6	factors	factor	NNS
cord-350836-1enteev7	107	7	to	to	TO
cord-350836-1enteev7	107	8	take	take	VB
cord-350836-1enteev7	107	9	into	into	IN
cord-350836-1enteev7	107	10	consideration	consideration	NN
cord-350836-1enteev7	107	11	with	with	IN
cord-350836-1enteev7	107	12	this	this	DT
cord-350836-1enteev7	107	13	study	study	NN
cord-350836-1enteev7	107	14	.	.	.
cord-350836-1enteev7	108	1	These	these	DT
cord-350836-1enteev7	108	2	recent	recent	JJ
cord-350836-1enteev7	108	3	results	result	NNS
cord-350836-1enteev7	108	4	were	be	VBD
cord-350836-1enteev7	108	5	obtained	obtain	VBN
cord-350836-1enteev7	108	6	using	use	VBG
cord-350836-1enteev7	108	7	KO	KO	NNP
cord-350836-1enteev7	108	8	293	293	CD
cord-350836-1enteev7	108	9	T	t	NN
cord-350836-1enteev7	108	10	and	and	CC
cord-350836-1enteev7	108	11	mouse	mouse	VB
cord-350836-1enteev7	108	12	embryonic	embryonic	JJ
cord-350836-1enteev7	108	13	fibroblast	fibroblast	NN
cord-350836-1enteev7	108	14	(	(	-LRB-
cord-350836-1enteev7	108	15	MEF	MEF	NNP
cord-350836-1enteev7	108	16	)	)	-RRB-
cord-350836-1enteev7	108	17	cells	cell	NNS
cord-350836-1enteev7	108	18	and	and	CC
cord-350836-1enteev7	108	19	that	that	IN
cord-350836-1enteev7	108	20	it	-PRON-	PRP
cord-350836-1enteev7	108	21	was	be	VBD
cord-350836-1enteev7	108	22	not	not	RB
cord-350836-1enteev7	108	23	clear	clear	JJ
cord-350836-1enteev7	108	24	whether	whether	IN
cord-350836-1enteev7	108	25	K63	K63	NNP
cord-350836-1enteev7	108	26	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	108	27	occurred	occur	VBD
cord-350836-1enteev7	108	28	at	at	IN
cord-350836-1enteev7	108	29	other	other	JJ
cord-350836-1enteev7	108	30	known	know	VBN
cord-350836-1enteev7	108	31	lysine	lysine	NN
cord-350836-1enteev7	108	32	sites	site	NNS
cord-350836-1enteev7	108	33	in	in	IN
cord-350836-1enteev7	108	34	RIG	rig	NN
cord-350836-1enteev7	108	35	-	-	HYPH
cord-350836-1enteev7	108	36	I.	i.	NN
cord-350836-1enteev7	109	1	The	the	DT
cord-350836-1enteev7	109	2	question	question	NN
cord-350836-1enteev7	109	3	remains	remain	VBZ
cord-350836-1enteev7	109	4	whether	whether	IN
cord-350836-1enteev7	109	5	Riplet	Riplet	NNP
cord-350836-1enteev7	109	6	can	can	MD
cord-350836-1enteev7	109	7	ubiquitinate	ubiquitinate	VB
cord-350836-1enteev7	109	8	other	other	JJ
cord-350836-1enteev7	109	9	lysine	lysine	NN
cord-350836-1enteev7	109	10	residues	residue	NNS
cord-350836-1enteev7	109	11	in	in	IN
cord-350836-1enteev7	109	12	the	the	DT
cord-350836-1enteev7	109	13	absence	absence	NN
cord-350836-1enteev7	109	14	of	of	IN
cord-350836-1enteev7	109	15	TRIM25	TRIM25	NNP
cord-350836-1enteev7	109	16	.	.	.
cord-350836-1enteev7	110	1	Additionally	additionally	RB
cord-350836-1enteev7	110	2	,	,	,
cord-350836-1enteev7	110	3	in	in	IN
cord-350836-1enteev7	110	4	-	-	HYPH
cord-350836-1enteev7	110	5	situ	situ	NN
cord-350836-1enteev7	110	6	experiments	experiment	NNS
cord-350836-1enteev7	110	7	comparing	compare	VBG
cord-350836-1enteev7	110	8	RIG-	RIG-	NNP
cord-350836-1enteev7	111	1	I	-PRON-	PRP
cord-350836-1enteev7	111	2	ubiquitination	ubiquitination	IN
cord-350836-1enteev7	111	3	by	by	IN
cord-350836-1enteev7	111	4	Riplet	Riplet	NNP
cord-350836-1enteev7	111	5	and	and	CC
cord-350836-1enteev7	111	6	TRIM25	TRIM25	NNP
cord-350836-1enteev7	111	7	utilized	utilize	VBD
cord-350836-1enteev7	111	8	an	an	DT
cord-350836-1enteev7	111	9	E2	E2	NNP
cord-350836-1enteev7	111	10	enzyme	enzyme	NN
cord-350836-1enteev7	111	11	(	(	-LRB-
cord-350836-1enteev7	111	12	103	103	CD
cord-350836-1enteev7	111	13	)	)	-RRB-
cord-350836-1enteev7	111	14	that	that	WDT
cord-350836-1enteev7	111	15	had	have	VBD
cord-350836-1enteev7	111	16	been	be	VBN
cord-350836-1enteev7	111	17	found	find	VBN
cord-350836-1enteev7	111	18	to	to	TO
cord-350836-1enteev7	111	19	be	be	VB
cord-350836-1enteev7	111	20	specific	specific	JJ
cord-350836-1enteev7	111	21	for	for	IN
cord-350836-1enteev7	111	22	Riplet	Riplet	NNP
cord-350836-1enteev7	111	23	(	(	-LRB-
cord-350836-1enteev7	111	24	107	107	CD
cord-350836-1enteev7	111	25	)	)	-RRB-
cord-350836-1enteev7	111	26	.	.	.
cord-350836-1enteev7	112	1	While	while	IN
cord-350836-1enteev7	112	2	the	the	DT
cord-350836-1enteev7	112	3	E2	E2	NNP
cord-350836-1enteev7	112	4	that	that	WDT
cord-350836-1enteev7	112	5	utilizes	utilize	VBZ
cord-350836-1enteev7	112	6	TRIM25	TRIM25	NNP
cord-350836-1enteev7	112	7	has	have	VBZ
cord-350836-1enteev7	112	8	not	not	RB
cord-350836-1enteev7	112	9	yet	yet	RB
cord-350836-1enteev7	112	10	been	be	VBN
cord-350836-1enteev7	112	11	identified	identify	VBN
cord-350836-1enteev7	112	12	,	,	,
cord-350836-1enteev7	112	13	TRIM25	TRIM25	NNP
cord-350836-1enteev7	112	14	has	have	VBZ
cord-350836-1enteev7	112	15	been	be	VBN
cord-350836-1enteev7	112	16	shown	show	VBN
cord-350836-1enteev7	112	17	to	to	IN
cord-350836-1enteev7	112	18	ubiquitinate	ubiquitinate	JJ
cord-350836-1enteev7	112	19	RIG-	RIG-	NNP
cord-350836-1enteev7	113	1	I	-PRON-	PRP
cord-350836-1enteev7	113	2	in	in	RB
cord-350836-1enteev7	113	3	-	-	HYPH
cord-350836-1enteev7	113	4	situ	situ	NN
cord-350836-1enteev7	113	5	when	when	WRB
cord-350836-1enteev7	113	6	a	a	DT
cord-350836-1enteev7	113	7	general	general	JJ
cord-350836-1enteev7	113	8	mixture	mixture	NN
cord-350836-1enteev7	113	9	of	of	IN
cord-350836-1enteev7	113	10	E2	E2	NNP
cord-350836-1enteev7	113	11	proteins	protein	NNS
cord-350836-1enteev7	113	12	was	be	VBD
cord-350836-1enteev7	113	13	used	use	VBN
cord-350836-1enteev7	113	14	(	(	-LRB-
cord-350836-1enteev7	113	15	108	108	CD
cord-350836-1enteev7	113	16	)	)	-RRB-
cord-350836-1enteev7	113	17	.	.	.
cord-350836-1enteev7	114	1	The	the	DT
cord-350836-1enteev7	114	2	protein	protein	NN
cord-350836-1enteev7	114	3	levels	level	NNS
cord-350836-1enteev7	114	4	of	of	IN
cord-350836-1enteev7	114	5	TRIM25	TRIM25	NNP
cord-350836-1enteev7	114	6	may	may	MD
cord-350836-1enteev7	114	7	also	also	RB
cord-350836-1enteev7	114	8	have	have	VB
cord-350836-1enteev7	114	9	to	to	TO
cord-350836-1enteev7	114	10	be	be	VB
cord-350836-1enteev7	114	11	at	at	IN
cord-350836-1enteev7	114	12	a	a	DT
cord-350836-1enteev7	114	13	certain	certain	JJ
cord-350836-1enteev7	114	14	level	level	NN
cord-350836-1enteev7	114	15	in	in	IN
cord-350836-1enteev7	114	16	order	order	NN
cord-350836-1enteev7	114	17	for	for	IN
cord-350836-1enteev7	114	18	it	-PRON-	PRP
cord-350836-1enteev7	114	19	to	to	TO
cord-350836-1enteev7	114	20	productively	productively	RB
cord-350836-1enteev7	114	21	ubiquitinate	ubiquitinate	VB
cord-350836-1enteev7	114	22	RIG-	rig-	NN
cord-350836-1enteev7	115	1	I	-PRON-	PRP
cord-350836-1enteev7	115	2	,	,	,
cord-350836-1enteev7	115	3	as	as	IN
cord-350836-1enteev7	115	4	the	the	DT
cord-350836-1enteev7	115	5	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	115	6	protease	protease	NN
cord-350836-1enteev7	115	7	USP15	USP15	NNP
cord-350836-1enteev7	115	8	deubiquitinates	deubiquitinates	NNP
cord-350836-1enteev7	115	9	TRIM25	TRIM25	NNP
cord-350836-1enteev7	115	10	at	at	IN
cord-350836-1enteev7	115	11	later	later	JJ
cord-350836-1enteev7	115	12	time	time	NN
cord-350836-1enteev7	115	13	points	point	NNS
cord-350836-1enteev7	115	14	in	in	IN
cord-350836-1enteev7	115	15	viral	viral	JJ
cord-350836-1enteev7	115	16	infection	infection	NN
cord-350836-1enteev7	115	17	(	(	-LRB-
cord-350836-1enteev7	115	18	109	109	CD
cord-350836-1enteev7	115	19	)	)	-RRB-
cord-350836-1enteev7	115	20	.	.	.
cord-350836-1enteev7	116	1	Finally	finally	RB
cord-350836-1enteev7	116	2	,	,	,
cord-350836-1enteev7	116	3	TRIM25	TRIM25	NNP
cord-350836-1enteev7	116	4	has	have	VBZ
cord-350836-1enteev7	116	5	been	be	VBN
cord-350836-1enteev7	116	6	found	find	VBN
cord-350836-1enteev7	116	7	to	to	TO
cord-350836-1enteev7	116	8	be	be	VB
cord-350836-1enteev7	116	9	essential	essential	JJ
cord-350836-1enteev7	116	10	for	for	IN
cord-350836-1enteev7	116	11	RIG	rig	NN
cord-350836-1enteev7	116	12	-	-	:
cord-350836-1enteev7	116	13	I	-PRON-	PRP
cord-350836-1enteev7	116	14	activation	activation	NN
cord-350836-1enteev7	116	15	and	and	CC
cord-350836-1enteev7	116	16	IFN	IFN	NNP
cord-350836-1enteev7	116	17	signaling	signal	VBG
cord-350836-1enteev7	116	18	in	in	IN
cord-350836-1enteev7	116	19	-	-	HYPH
cord-350836-1enteev7	116	20	vitro	vitro	FW
cord-350836-1enteev7	116	21	and	and	CC
cord-350836-1enteev7	116	22	in	in	IN
cord-350836-1enteev7	116	23	-	-	HYPH
cord-350836-1enteev7	116	24	vivo	vivo	NN
cord-350836-1enteev7	116	25	.	.	.
cord-350836-1enteev7	117	1	For	for	IN
cord-350836-1enteev7	117	2	the	the	DT
cord-350836-1enteev7	117	3	former	former	JJ
cord-350836-1enteev7	117	4	,	,	,
cord-350836-1enteev7	117	5	siRNA	siRNA	NNP
cord-350836-1enteev7	117	6	-	-	HYPH
cord-350836-1enteev7	117	7	mediated	mediate	VBN
cord-350836-1enteev7	117	8	knock	knock	NN
cord-350836-1enteev7	117	9	-	-	HYPH
cord-350836-1enteev7	117	10	down	down	NN
cord-350836-1enteev7	117	11	(	(	-LRB-
cord-350836-1enteev7	117	12	110	110	CD
cord-350836-1enteev7	117	13	,	,	,
cord-350836-1enteev7	117	14	111	111	CD
cord-350836-1enteev7	117	15	)	)	-RRB-
cord-350836-1enteev7	117	16	,	,	,
cord-350836-1enteev7	117	17	cellular	cellular	JJ
cord-350836-1enteev7	117	18	knockout	knockout	NN
cord-350836-1enteev7	117	19	(	(	-LRB-
cord-350836-1enteev7	117	20	112	112	CD
cord-350836-1enteev7	117	21	)	)	-RRB-
cord-350836-1enteev7	117	22	and	and	CC
cord-350836-1enteev7	117	23	inhibition	inhibition	NN
cord-350836-1enteev7	117	24	by	by	IN
cord-350836-1enteev7	117	25	viral	viral	JJ
cord-350836-1enteev7	117	26	protein	protein	NN
cord-350836-1enteev7	117	27	(	(	-LRB-
cord-350836-1enteev7	117	28	109	109	CD
cord-350836-1enteev7	117	29	,	,	,
cord-350836-1enteev7	117	30	(	(	-LRB-
cord-350836-1enteev7	117	31	113	113	CD
cord-350836-1enteev7	117	32	)	)	-RRB-
cord-350836-1enteev7	117	33	(	(	-LRB-
cord-350836-1enteev7	117	34	114	114	CD
cord-350836-1enteev7	117	35	)	)	-RRB-
cord-350836-1enteev7	117	36	(	(	-LRB-
cord-350836-1enteev7	117	37	115	115	CD
cord-350836-1enteev7	117	38	)	)	-RRB-
cord-350836-1enteev7	117	39	(	(	-LRB-
cord-350836-1enteev7	117	40	116	116	CD
cord-350836-1enteev7	117	41	)	)	-RRB-
cord-350836-1enteev7	117	42	conditions	condition	NNS
cord-350836-1enteev7	117	43	for	for	IN
cord-350836-1enteev7	117	44	TRIM25	trim25	CD
cord-350836-1enteev7	117	45	in	in	IN
cord-350836-1enteev7	117	46	multiple	multiple	JJ
cord-350836-1enteev7	117	47	cell	cell	NN
cord-350836-1enteev7	117	48	types	type	NNS
cord-350836-1enteev7	117	49	have	have	VBP
cord-350836-1enteev7	117	50	been	be	VBN
cord-350836-1enteev7	117	51	shown	show	VBN
cord-350836-1enteev7	117	52	to	to	TO
cord-350836-1enteev7	117	53	change	change	VB
cord-350836-1enteev7	117	54	RIG	rig	NN
cord-350836-1enteev7	117	55	-	-	:
cord-350836-1enteev7	117	56	I	-PRON-	PRP
cord-350836-1enteev7	117	57	cellular	cellular	JJ
cord-350836-1enteev7	117	58	localization	localization	NN
cord-350836-1enteev7	117	59	(	(	-LRB-
cord-350836-1enteev7	117	60	110	110	CD
cord-350836-1enteev7	117	61	)	)	-RRB-
cord-350836-1enteev7	117	62	and	and	CC
cord-350836-1enteev7	117	63	to	to	TO
cord-350836-1enteev7	117	64	negatively	negatively	RB
cord-350836-1enteev7	117	65	affect	affect	VB
cord-350836-1enteev7	117	66	RIG	rig	NN
cord-350836-1enteev7	117	67	-	-	:
cord-350836-1enteev7	117	68	I	-PRON-	PRP
cord-350836-1enteev7	117	69	K63	K63	NNPS
cord-350836-1enteev7	117	70	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	117	71	,	,	,
cord-350836-1enteev7	117	72	association	association	NN
cord-350836-1enteev7	117	73	with	with	IN
cord-350836-1enteev7	117	74	MAVS	MAVS	NNPS
cord-350836-1enteev7	117	75	and	and	CC
cord-350836-1enteev7	117	76	IFN	IFN	NNP
cord-350836-1enteev7	117	77	signaling	signal	VBG
cord-350836-1enteev7	117	78	[	[	-LRB-
cord-350836-1enteev7	118	1	when	when	WRB
cord-350836-1enteev7	118	2	the	the	DT
cord-350836-1enteev7	118	3	constitutively	constitutively	RB
cord-350836-1enteev7	118	4	active	active	JJ
cord-350836-1enteev7	118	5	RIG	rig	NN
cord-350836-1enteev7	118	6	-	-	:
cord-350836-1enteev7	118	7	I	-PRON-	PRP
cord-350836-1enteev7	118	8	CARD	card	NN
cord-350836-1enteev7	118	9	domain	domain	NN
cord-350836-1enteev7	118	10	was	be	VBD
cord-350836-1enteev7	118	11	overexpressed	overexpresse	VBN
cord-350836-1enteev7	118	12	(	(	-LRB-
cord-350836-1enteev7	118	13	109	109	CD
cord-350836-1enteev7	118	14	,	,	,
cord-350836-1enteev7	118	15	(	(	-LRB-
cord-350836-1enteev7	118	16	112	112	CD
cord-350836-1enteev7	118	17	)	)	-RRB-
cord-350836-1enteev7	118	18	(	(	-LRB-
cord-350836-1enteev7	118	19	113	113	CD
cord-350836-1enteev7	118	20	)	)	-RRB-
cord-350836-1enteev7	118	21	(	(	-LRB-
cord-350836-1enteev7	118	22	114	114	CD
cord-350836-1enteev7	118	23	)	)	-RRB-
cord-350836-1enteev7	118	24	(	(	-LRB-
cord-350836-1enteev7	118	25	115	115	CD
cord-350836-1enteev7	118	26	)	)	-RRB-
cord-350836-1enteev7	118	27	(	(	-LRB-
cord-350836-1enteev7	118	28	116	116	CD
cord-350836-1enteev7	118	29	)	)	-RRB-
cord-350836-1enteev7	118	30	or	or	CC
cord-350836-1enteev7	118	31	during	during	IN
cord-350836-1enteev7	118	32	viral	viral	JJ
cord-350836-1enteev7	118	33	infection	infection	NN
cord-350836-1enteev7	118	34	(	(	-LRB-
cord-350836-1enteev7	118	35	109	109	CD
cord-350836-1enteev7	118	36	,	,	,
cord-350836-1enteev7	118	37	111	111	CD
cord-350836-1enteev7	118	38	,	,	,
cord-350836-1enteev7	118	39	114	114	CD
cord-350836-1enteev7	118	40	)	)	-RRB-
cord-350836-1enteev7	118	41	]	]	-RRB-
cord-350836-1enteev7	118	42	.	.	.
cord-350836-1enteev7	119	1	Viral	viral	JJ
cord-350836-1enteev7	119	2	inhibition	inhibition	NN
cord-350836-1enteev7	119	3	of	of	IN
cord-350836-1enteev7	119	4	TRIM25	TRIM25	NNP
cord-350836-1enteev7	119	5	may	may	MD
cord-350836-1enteev7	119	6	even	even	RB
cord-350836-1enteev7	119	7	be	be	VB
cord-350836-1enteev7	119	8	a	a	DT
cord-350836-1enteev7	119	9	source	source	NN
cord-350836-1enteev7	119	10	of	of	IN
cord-350836-1enteev7	119	11	a	a	DT
cord-350836-1enteev7	119	12	positive	positive	JJ
cord-350836-1enteev7	119	13	selection	selection	NN
cord-350836-1enteev7	119	14	during	during	IN
cord-350836-1enteev7	119	15	the	the	DT
cord-350836-1enteev7	119	16	evolution	evolution	NN
cord-350836-1enteev7	119	17	of	of	IN
cord-350836-1enteev7	119	18	certain	certain	JJ
cord-350836-1enteev7	119	19	viruses	virus	NNS
cord-350836-1enteev7	119	20	,	,	,
cord-350836-1enteev7	119	21	as	as	IN
cord-350836-1enteev7	119	22	NS1	ns1	NN
cord-350836-1enteev7	119	23	IAV	IAV	NNP
cord-350836-1enteev7	119	24	proteins	protein	NNS
cord-350836-1enteev7	119	25	have	have	VBP
cord-350836-1enteev7	119	26	been	be	VBN
cord-350836-1enteev7	119	27	found	find	VBN
cord-350836-1enteev7	119	28	to	to	TO
cord-350836-1enteev7	119	29	interact	interact	VB
cord-350836-1enteev7	119	30	with	with	IN
cord-350836-1enteev7	119	31	species	specie	NNS
cord-350836-1enteev7	119	32	specific	specific	JJ
cord-350836-1enteev7	120	1	TRIM25	TRIM25	NNP
cord-350836-1enteev7	120	2	(	(	-LRB-
cord-350836-1enteev7	120	3	114	114	CD
cord-350836-1enteev7	120	4	)	)	-RRB-
cord-350836-1enteev7	120	5	.	.	.
cord-350836-1enteev7	121	1	For	for	IN
cord-350836-1enteev7	121	2	the	the	DT
cord-350836-1enteev7	121	3	latter	latter	JJ
cord-350836-1enteev7	121	4	,	,	,
cord-350836-1enteev7	121	5	MEFs	mef	NNS
cord-350836-1enteev7	121	6	from	from	IN
cord-350836-1enteev7	121	7	TRIM25	TRIM25	NNP
cord-350836-1enteev7	121	8	KO	KO	NNP
cord-350836-1enteev7	121	9	mice	mouse	NNS
cord-350836-1enteev7	121	10	have	have	VBP
cord-350836-1enteev7	121	11	significantly	significantly	RB
cord-350836-1enteev7	121	12	downregulated	downregulate	VBN
cord-350836-1enteev7	121	13	IFN1	IFN1	NNP
cord-350836-1enteev7	121	14	production	production	NN
cord-350836-1enteev7	121	15	upon	upon	IN
cord-350836-1enteev7	121	16	viral	viral	JJ
cord-350836-1enteev7	121	17	infection	infection	NN
cord-350836-1enteev7	121	18	(	(	-LRB-
cord-350836-1enteev7	121	19	113	113	CD
cord-350836-1enteev7	121	20	)	)	-RRB-
cord-350836-1enteev7	121	21	and	and	CC
cord-350836-1enteev7	121	22	KO	KO	NNP
cord-350836-1enteev7	121	23	mice	mouse	NNS
cord-350836-1enteev7	121	24	for	for	IN
cord-350836-1enteev7	121	25	NLRP12	NLRP12	NNP
cord-350836-1enteev7	121	26	,	,	,
cord-350836-1enteev7	121	27	which	which	WDT
cord-350836-1enteev7	121	28	is	be	VBZ
cord-350836-1enteev7	121	29	a	a	DT
cord-350836-1enteev7	121	30	competitive	competitive	JJ
cord-350836-1enteev7	121	31	interactor	interactor	NN
cord-350836-1enteev7	121	32	with	with	IN
cord-350836-1enteev7	121	33	TRIM25	TRIM25	NNP
cord-350836-1enteev7	121	34	to	to	IN
cord-350836-1enteev7	121	35	RIG	rig	NN
cord-350836-1enteev7	121	36	-	-	:
cord-350836-1enteev7	121	37	I	-PRON-	PRP
cord-350836-1enteev7	121	38	,	,	,
cord-350836-1enteev7	121	39	show	show	VB
cord-350836-1enteev7	121	40	increased	increase	VBN
cord-350836-1enteev7	121	41	interferon	interferon	NN
cord-350836-1enteev7	121	42	production	production	NN
cord-350836-1enteev7	121	43	and	and	CC
cord-350836-1enteev7	121	44	more	more	JJR
cord-350836-1enteev7	121	45	resistance	resistance	NN
cord-350836-1enteev7	121	46	to	to	IN
cord-350836-1enteev7	121	47	viral	viral	JJ
cord-350836-1enteev7	121	48	infection	infection	NN
cord-350836-1enteev7	121	49	(	(	-LRB-
cord-350836-1enteev7	121	50	117	117	CD
cord-350836-1enteev7	121	51	)	)	-RRB-
cord-350836-1enteev7	121	52	.	.	.
cord-350836-1enteev7	122	1	The	the	DT
cord-350836-1enteev7	122	2	known	know	VBN
cord-350836-1enteev7	122	3	contributions	contribution	NNS
cord-350836-1enteev7	122	4	of	of	IN
cord-350836-1enteev7	122	5	TRIM25	TRIM25	NNP
cord-350836-1enteev7	122	6	to	to	TO
cord-350836-1enteev7	122	7	innate	innate	JJ
cord-350836-1enteev7	122	8	immunity	immunity	NN
cord-350836-1enteev7	122	9	have	have	VBP
cord-350836-1enteev7	122	10	recently	recently	RB
cord-350836-1enteev7	122	11	been	be	VBN
cord-350836-1enteev7	122	12	summarized	summarize	VBN
cord-350836-1enteev7	122	13	elsewhere	elsewhere	RB
cord-350836-1enteev7	122	14	(	(	-LRB-
cord-350836-1enteev7	122	15	52	52	CD
cord-350836-1enteev7	122	16	)	)	-RRB-
cord-350836-1enteev7	122	17	.	.	.
cord-350836-1enteev7	123	1	It	-PRON-	PRP
cord-350836-1enteev7	123	2	is	be	VBZ
cord-350836-1enteev7	123	3	clear	clear	JJ
cord-350836-1enteev7	123	4	that	that	IN
cord-350836-1enteev7	123	5	both	both	CC
cord-350836-1enteev7	123	6	Riplet	Riplet	NNP
cord-350836-1enteev7	123	7	and	and	CC
cord-350836-1enteev7	123	8	TRIM25	TRIM25	NNP
cord-350836-1enteev7	123	9	can	can	MD
cord-350836-1enteev7	123	10	mediate	mediate	VB
cord-350836-1enteev7	123	11	K63linked	K63linked	NNP
cord-350836-1enteev7	123	12	polyubiquitination	polyubiquitination	NN
cord-350836-1enteev7	123	13	.	.	.
cord-350836-1enteev7	124	1	However	however	RB
cord-350836-1enteev7	124	2	,	,	,
cord-350836-1enteev7	124	3	it	-PRON-	PRP
cord-350836-1enteev7	124	4	has	have	VBZ
cord-350836-1enteev7	124	5	also	also	RB
cord-350836-1enteev7	124	6	been	be	VBN
cord-350836-1enteev7	124	7	found	find	VBN
cord-350836-1enteev7	124	8	that	that	IN
cord-350836-1enteev7	124	9	in	in	IN
cord-350836-1enteev7	124	10	-	-	HYPH
cord-350836-1enteev7	124	11	situ	situ	JJ
cord-350836-1enteev7	124	12	incubation	incubation	NN
cord-350836-1enteev7	124	13	of	of	IN
cord-350836-1enteev7	124	14	purified	purify	VBN
cord-350836-1enteev7	124	15	RIG	rig	NN
cord-350836-1enteev7	124	16	-	-	HYPH
cord-350836-1enteev7	124	17	I	i	NN
cord-350836-1enteev7	124	18	CARD	card	NN
cord-350836-1enteev7	124	19	domains	domain	NNS
cord-350836-1enteev7	124	20	with	with	IN
cord-350836-1enteev7	124	21	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	124	22	can	can	MD
cord-350836-1enteev7	124	23	be	be	VB
cord-350836-1enteev7	124	24	activated	activate	VBN
cord-350836-1enteev7	124	25	by	by	IN
cord-350836-1enteev7	124	26	free	free	JJ
cord-350836-1enteev7	124	27	and	and	CC
cord-350836-1enteev7	124	28	unlinked	unlinked	JJ
cord-350836-1enteev7	124	29	K63	K63	NNP
cord-350836-1enteev7	124	30	polyubiquitin	polyubiquitin	NNS
cord-350836-1enteev7	124	31	chains	chain	NNS
cord-350836-1enteev7	124	32	(	(	-LRB-
cord-350836-1enteev7	124	33	118	118	CD
cord-350836-1enteev7	124	34	)	)	-RRB-
cord-350836-1enteev7	124	35	,	,	,
cord-350836-1enteev7	124	36	calling	call	VBG
cord-350836-1enteev7	124	37	into	into	IN
cord-350836-1enteev7	124	38	question	question	NN
cord-350836-1enteev7	124	39	whether	whether	IN
cord-350836-1enteev7	124	40	TRIM25	TRIM25	NNP
cord-350836-1enteev7	124	41	only	only	RB
cord-350836-1enteev7	124	42	attaches	attach	VBZ
cord-350836-1enteev7	124	43	K63-linked	K63-linked	NNP
cord-350836-1enteev7	124	44	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	124	45	motifs	motif	NNS
cord-350836-1enteev7	124	46	to	to	IN
cord-350836-1enteev7	124	47	RIG	rig	NN
cord-350836-1enteev7	124	48	-	-	HYPH
cord-350836-1enteev7	124	49	I	i	NN
cord-350836-1enteev7	124	50	-	-	HYPH
cord-350836-1enteev7	124	51	CARD	card	NN
cord-350836-1enteev7	124	52	or	or	CC
cord-350836-1enteev7	124	53	if	if	IN
cord-350836-1enteev7	124	54	it	-PRON-	PRP
cord-350836-1enteev7	124	55	also	also	RB
cord-350836-1enteev7	124	56	catalyzes	catalyze	VBZ
cord-350836-1enteev7	124	57	the	the	DT
cord-350836-1enteev7	124	58	formation	formation	NN
cord-350836-1enteev7	124	59	of	of	IN
cord-350836-1enteev7	124	60	unlinked	unlinked	JJ
cord-350836-1enteev7	124	61	K63	K63	NNPS
cord-350836-1enteev7	124	62	polyubiquitination	polyubiquitination	NN
cord-350836-1enteev7	124	63	chains	chain	NNS
cord-350836-1enteev7	124	64	(	(	-LRB-
cord-350836-1enteev7	124	65	119	119	CD
cord-350836-1enteev7	124	66	)	)	-RRB-
cord-350836-1enteev7	124	67	.	.	.
cord-350836-1enteev7	125	1	A	a	DT
cord-350836-1enteev7	125	2	possible	possible	JJ
cord-350836-1enteev7	125	3	explanation	explanation	NN
cord-350836-1enteev7	125	4	for	for	IN
cord-350836-1enteev7	125	5	these	these	DT
cord-350836-1enteev7	125	6	differing	differ	VBG
cord-350836-1enteev7	125	7	results	result	NNS
cord-350836-1enteev7	125	8	is	be	VBZ
cord-350836-1enteev7	125	9	that	that	DT
cord-350836-1enteev7	125	10	RIG	rig	NN
cord-350836-1enteev7	125	11	-	-	:
cord-350836-1enteev7	125	12	I	-PRON-	PRP
cord-350836-1enteev7	125	13	has	have	VBZ
cord-350836-1enteev7	125	14	been	be	VBN
cord-350836-1enteev7	125	15	shown	show	VBN
cord-350836-1enteev7	125	16	to	to	TO
cord-350836-1enteev7	125	17	be	be	VB
cord-350836-1enteev7	125	18	covalently	covalently	RB
cord-350836-1enteev7	125	19	K63	K63	NNP
cord-350836-1enteev7	125	20	ubiquitinated	ubiquitinate	VBN
cord-350836-1enteev7	125	21	by	by	IN
cord-350836-1enteev7	125	22	TRIM25	TRIM25	NNP
cord-350836-1enteev7	125	23	when	when	WRB
cord-350836-1enteev7	125	24	analyzed	analyze	VBN
cord-350836-1enteev7	125	25	by	by	IN
cord-350836-1enteev7	125	26	mass	mass	NN
cord-350836-1enteev7	125	27	spectrometry	spectrometry	NN
cord-350836-1enteev7	125	28	from	from	IN
cord-350836-1enteev7	125	29	cells	cell	NNS
cord-350836-1enteev7	125	30	(	(	-LRB-
cord-350836-1enteev7	125	31	104	104	CD
cord-350836-1enteev7	125	32	)	)	-RRB-
cord-350836-1enteev7	125	33	,	,	,
cord-350836-1enteev7	125	34	while	while	IN
cord-350836-1enteev7	125	35	experiments	experiment	NNS
cord-350836-1enteev7	125	36	that	that	WDT
cord-350836-1enteev7	125	37	demonstrate	demonstrate	VBP
cord-350836-1enteev7	125	38	non	non	JJ
cord-350836-1enteev7	125	39	-	-	JJ
cord-350836-1enteev7	125	40	covalent	covalent	JJ
cord-350836-1enteev7	125	41	K63	K63	NNP
cord-350836-1enteev7	125	42	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	125	43	are	be	VBP
cord-350836-1enteev7	125	44	those	those	DT
cord-350836-1enteev7	125	45	involve	involve	VBP
cord-350836-1enteev7	125	46	primarily	primarily	RB
cord-350836-1enteev7	125	47	interactions	interaction	NNS
cord-350836-1enteev7	125	48	with	with	IN
cord-350836-1enteev7	125	49	purified	purify	VBN
cord-350836-1enteev7	125	50	proteins	protein	NNS
cord-350836-1enteev7	125	51	.	.	.
cord-350836-1enteev7	126	1	It	-PRON-	PRP
cord-350836-1enteev7	126	2	has	have	VBZ
cord-350836-1enteev7	126	3	also	also	RB
cord-350836-1enteev7	126	4	been	be	VBN
cord-350836-1enteev7	126	5	recently	recently	RB
cord-350836-1enteev7	126	6	found	find	VBN
cord-350836-1enteev7	126	7	that	that	IN
cord-350836-1enteev7	126	8	RIG	rig	NN
cord-350836-1enteev7	126	9	-	-	:
cord-350836-1enteev7	126	10	I	-PRON-	PRP
cord-350836-1enteev7	126	11	is	be	VBZ
cord-350836-1enteev7	126	12	K63	K63	NNP
cord-350836-1enteev7	126	13	ubiquitinated	ubiquitinate	VBN
cord-350836-1enteev7	126	14	at	at	IN
cord-350836-1enteev7	126	15	K164	k164	ADD
cord-350836-1enteev7	126	16	and	and	CC
cord-350836-1enteev7	126	17	that	that	IN
cord-350836-1enteev7	126	18	it	-PRON-	PRP
cord-350836-1enteev7	126	19	may	may	MD
cord-350836-1enteev7	126	20	be	be	VB
cord-350836-1enteev7	126	21	functionally	functionally	RB
cord-350836-1enteev7	126	22	redundant	redundant	JJ
cord-350836-1enteev7	126	23	to	to	IN
cord-350836-1enteev7	126	24	K172	K172	NNP
cord-350836-1enteev7	126	25	(	(	-LRB-
cord-350836-1enteev7	126	26	120	120	CD
cord-350836-1enteev7	126	27	,	,	,
cord-350836-1enteev7	126	28	121	121	CD
cord-350836-1enteev7	126	29	)	)	-RRB-
cord-350836-1enteev7	126	30	,	,	,
cord-350836-1enteev7	126	31	with	with	IN
cord-350836-1enteev7	126	32	their	-PRON-	PRP$
cord-350836-1enteev7	126	33	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	126	34	possibly	possibly	RB
cord-350836-1enteev7	126	35	upregulating	upregulate	VBG
cord-350836-1enteev7	126	36	the	the	DT
cord-350836-1enteev7	126	37	K63	K63	NNPS
cord-350836-1enteev7	126	38	ubiquitination	ubiquitination	IN
cord-350836-1enteev7	126	39	of	of	IN
cord-350836-1enteev7	126	40	the	the	DT
cord-350836-1enteev7	126	41	other	other	JJ
cord-350836-1enteev7	126	42	6	6	CD
cord-350836-1enteev7	126	43	lysine	lysine	NN
cord-350836-1enteev7	126	44	residues	residue	NNS
cord-350836-1enteev7	126	45	in	in	IN
cord-350836-1enteev7	126	46	RIG	rig	NN
cord-350836-1enteev7	126	47	-	-	:
cord-350836-1enteev7	126	48	I	i	NN
cord-350836-1enteev7	126	49	(	(	-LRB-
cord-350836-1enteev7	126	50	121	121	CD
cord-350836-1enteev7	126	51	)	)	-RRB-
cord-350836-1enteev7	126	52	.	.	.
cord-350836-1enteev7	127	1	However	however	RB
cord-350836-1enteev7	127	2	,	,	,
cord-350836-1enteev7	127	3	it	-PRON-	PRP
cord-350836-1enteev7	127	4	is	be	VBZ
cord-350836-1enteev7	127	5	unknown	unknown	JJ
cord-350836-1enteev7	127	6	whether	whether	IN
cord-350836-1enteev7	127	7	TRIM25	TRIM25	NNP
cord-350836-1enteev7	127	8	ubiquitinates	ubiquitinate	NNS
cord-350836-1enteev7	127	9	K164	K164	NNPS
cord-350836-1enteev7	127	10	or	or	CC
cord-350836-1enteev7	127	11	any	any	DT
cord-350836-1enteev7	127	12	of	of	IN
cord-350836-1enteev7	127	13	the	the	DT
cord-350836-1enteev7	127	14	other	other	JJ
cord-350836-1enteev7	127	15	RIG	rig	NN
cord-350836-1enteev7	127	16	-	-	HYPH
cord-350836-1enteev7	127	17	I	-PRON-	PRP
cord-350836-1enteev7	127	18	lysine	lysine	NN
cord-350836-1enteev7	127	19	residues	residue	NNS
cord-350836-1enteev7	127	20	.	.	.
cord-350836-1enteev7	128	1	Notably	notably	RB
cord-350836-1enteev7	128	2	,	,	,
cord-350836-1enteev7	128	3	these	these	DT
cord-350836-1enteev7	128	4	additional	additional	JJ
cord-350836-1enteev7	128	5	lysine	lysine	NN
cord-350836-1enteev7	128	6	residues	residue	NNS
cord-350836-1enteev7	128	7	in	in	IN
cord-350836-1enteev7	128	8	the	the	DT
cord-350836-1enteev7	128	9	CARD	card	NN
cord-350836-1enteev7	128	10	and	and	CC
cord-350836-1enteev7	128	11	C	c	NN
cord-350836-1enteev7	128	12	terminal	terminal	NN
cord-350836-1enteev7	128	13	domains	domain	NNS
cord-350836-1enteev7	128	14	of	of	IN
cord-350836-1enteev7	128	15	RIG	rig	NN
cord-350836-1enteev7	128	16	-	-	:
cord-350836-1enteev7	128	17	I	I	NNP
cord-350836-1enteev7	128	18	and	and	CC
cord-350836-1enteev7	128	19	MDA5	MDA5	NNP
cord-350836-1enteev7	128	20	are	be	VBP
cord-350836-1enteev7	128	21	known	know	VBN
cord-350836-1enteev7	128	22	to	to	TO
cord-350836-1enteev7	128	23	be	be	VB
cord-350836-1enteev7	128	24	K27	K27	NNP
cord-350836-1enteev7	128	25	and	and	CC
cord-350836-1enteev7	128	26	K48	K48	NNP
cord-350836-1enteev7	128	27	ubiquitinated	ubiquitinate	VBD
cord-350836-1enteev7	128	28	[	[	-LRB-
cord-350836-1enteev7	128	29	which	which	WDT
cord-350836-1enteev7	128	30	are	be	VBP
cord-350836-1enteev7	128	31	associated	associate	VBN
cord-350836-1enteev7	128	32	with	with	IN
cord-350836-1enteev7	128	33	degradation	degradation	NN
cord-350836-1enteev7	128	34	of	of	IN
cord-350836-1enteev7	128	35	RIG	rig	NN
cord-350836-1enteev7	128	36	-	-	:
cord-350836-1enteev7	128	37	I	i	NN
cord-350836-1enteev7	128	38	(	(	-LRB-
cord-350836-1enteev7	128	39	122	122	CD
cord-350836-1enteev7	128	40	,	,	,
cord-350836-1enteev7	128	41	123	123	CD
cord-350836-1enteev7	128	42	)	)	-RRB-
cord-350836-1enteev7	128	43	and	and	CC
cord-350836-1enteev7	128	44	MDA5	MDA5	NNP
cord-350836-1enteev7	128	45	(	(	-LRB-
cord-350836-1enteev7	128	46	123	123	CD
cord-350836-1enteev7	128	47	)	)	-RRB-
cord-350836-1enteev7	128	48	]	]	-RRB-
cord-350836-1enteev7	128	49	,	,	,
cord-350836-1enteev7	128	50	but	but	CC
cord-350836-1enteev7	128	51	the	the	DT
cord-350836-1enteev7	128	52	four	four	CD
cord-350836-1enteev7	128	53	listed	list	VBN
cord-350836-1enteev7	128	54	above	above	RB
cord-350836-1enteev7	128	55	appear	appear	VBP
cord-350836-1enteev7	128	56	to	to	TO
cord-350836-1enteev7	128	57	be	be	VB
cord-350836-1enteev7	128	58	the	the	DT
cord-350836-1enteev7	128	59	essential	essential	JJ
cord-350836-1enteev7	128	60	residues	residue	NNS
cord-350836-1enteev7	128	61	for	for	IN
cord-350836-1enteev7	128	62	activation	activation	NN
cord-350836-1enteev7	128	63	of	of	IN
cord-350836-1enteev7	128	64	RIG	rig	NN
cord-350836-1enteev7	128	65	-	-	:
cord-350836-1enteev7	128	66	I	i	NN
cord-350836-1enteev7	128	67	(	(	-LRB-
cord-350836-1enteev7	128	68	122	122	CD
cord-350836-1enteev7	128	69	,	,	,
cord-350836-1enteev7	128	70	124	124	CD
cord-350836-1enteev7	128	71	)	)	-RRB-
cord-350836-1enteev7	128	72	.	.	.
cord-350836-1enteev7	129	1	The	the	DT
cord-350836-1enteev7	129	2	presence	presence	NN
cord-350836-1enteev7	129	3	of	of	IN
cord-350836-1enteev7	129	4	K63	K63	NNP
cord-350836-1enteev7	129	5	ubiquitin	ubiquitin	JJ
cord-350836-1enteev7	129	6	modifications	modification	NNS
cord-350836-1enteev7	129	7	on	on	IN
cord-350836-1enteev7	129	8	MDA5	MDA5	NNP
cord-350836-1enteev7	129	9	is	be	VBZ
cord-350836-1enteev7	129	10	more	more	RBR
cord-350836-1enteev7	129	11	controversial	controversial	JJ
cord-350836-1enteev7	129	12	.	.	.
cord-350836-1enteev7	130	1	Independent	independent	JJ
cord-350836-1enteev7	130	2	studies	study	NNS
cord-350836-1enteev7	130	3	have	have	VBP
cord-350836-1enteev7	130	4	found	find	VBN
cord-350836-1enteev7	130	5	that	that	IN
cord-350836-1enteev7	130	6	MDA5	MDA5	NNP
cord-350836-1enteev7	130	7	is	be	VBZ
cord-350836-1enteev7	130	8	(	(	-LRB-
cord-350836-1enteev7	130	9	125	125	CD
cord-350836-1enteev7	130	10	,	,	,
cord-350836-1enteev7	130	11	126	126	CD
cord-350836-1enteev7	130	12	)	)	-RRB-
cord-350836-1enteev7	130	13	or	or	CC
cord-350836-1enteev7	130	14	is	be	VBZ
cord-350836-1enteev7	130	15	not	not	RB
cord-350836-1enteev7	130	16	(	(	-LRB-
cord-350836-1enteev7	130	17	126	126	CD
cord-350836-1enteev7	130	18	)	)	-RRB-
cord-350836-1enteev7	130	19	K63	K63	NNP
cord-350836-1enteev7	130	20	polyubiquitinated	polyubiquitinate	VBD
cord-350836-1enteev7	130	21	.	.	.
cord-350836-1enteev7	131	1	It	-PRON-	PRP
cord-350836-1enteev7	131	2	has	have	VBZ
cord-350836-1enteev7	131	3	also	also	RB
cord-350836-1enteev7	131	4	been	be	VBN
cord-350836-1enteev7	131	5	independently	independently	RB
cord-350836-1enteev7	131	6	found	find	VBN
cord-350836-1enteev7	131	7	that	that	IN
cord-350836-1enteev7	131	8	TRIM25	TRIM25	NNP
cord-350836-1enteev7	131	9	does	do	VBZ
cord-350836-1enteev7	131	10	not	not	RB
cord-350836-1enteev7	131	11	affect	affect	VB
cord-350836-1enteev7	131	12	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	131	13	of	of	IN
cord-350836-1enteev7	131	14	MDA5	MDA5	NNP
cord-350836-1enteev7	131	15	(	(	-LRB-
cord-350836-1enteev7	131	16	without	without	IN
cord-350836-1enteev7	131	17	distinguishing	distinguish	VBG
cord-350836-1enteev7	131	18	between	between	IN
cord-350836-1enteev7	131	19	K63	K63	NNP
cord-350836-1enteev7	131	20	and	and	CC
cord-350836-1enteev7	131	21	K48	K48	NNP
cord-350836-1enteev7	131	22	polyubiquitination	polyubiquitination	NN
cord-350836-1enteev7	131	23	)	)	-RRB-
cord-350836-1enteev7	131	24	(	(	-LRB-
cord-350836-1enteev7	131	25	104	104	CD
cord-350836-1enteev7	131	26	)	)	-RRB-
cord-350836-1enteev7	131	27	and	and	CC
cord-350836-1enteev7	131	28	for	for	IN
cord-350836-1enteev7	131	29	TRIM25	TRIM25	NNP
cord-350836-1enteev7	131	30	to	to	TO
cord-350836-1enteev7	131	31	increase	increase	VB
cord-350836-1enteev7	131	32	K63	K63	NNP
cord-350836-1enteev7	131	33	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	131	34	(	(	-LRB-
cord-350836-1enteev7	131	35	125	125	CD
cord-350836-1enteev7	131	36	)	)	-RRB-
cord-350836-1enteev7	131	37	,	,	,
cord-350836-1enteev7	131	38	the	the	DT
cord-350836-1enteev7	131	39	only	only	JJ
cord-350836-1enteev7	131	40	apparent	apparent	JJ
cord-350836-1enteev7	131	41	difference	difference	NN
cord-350836-1enteev7	131	42	in	in	IN
cord-350836-1enteev7	131	43	the	the	DT
cord-350836-1enteev7	131	44	experimental	experimental	JJ
cord-350836-1enteev7	131	45	models	model	NNS
cord-350836-1enteev7	131	46	being	be	VBG
cord-350836-1enteev7	131	47	the	the	DT
cord-350836-1enteev7	131	48	usage	usage	NN
cord-350836-1enteev7	131	49	of	of	IN
cord-350836-1enteev7	131	50	HEK293	HEK293	NNP
cord-350836-1enteev7	131	51	T	t	NN
cord-350836-1enteev7	131	52	(	(	-LRB-
cord-350836-1enteev7	131	53	104	104	CD
cord-350836-1enteev7	131	54	,	,	,
cord-350836-1enteev7	131	55	126	126	CD
cord-350836-1enteev7	131	56	)	)	-RRB-
cord-350836-1enteev7	131	57	vs.	vs.	FW
cord-350836-1enteev7	131	58	HEK293	HEK293	NNP
cord-350836-1enteev7	131	59	(	(	-LRB-
cord-350836-1enteev7	131	60	125	125	CD
cord-350836-1enteev7	131	61	)	)	-RRB-
cord-350836-1enteev7	131	62	cells	cell	NNS
cord-350836-1enteev7	131	63	.	.	.
cord-350836-1enteev7	132	1	TRIM65	TRIM65	NNP
cord-350836-1enteev7	132	2	has	have	VBZ
cord-350836-1enteev7	132	3	also	also	RB
cord-350836-1enteev7	132	4	been	be	VBN
cord-350836-1enteev7	132	5	recently	recently	RB
cord-350836-1enteev7	132	6	found	find	VBN
cord-350836-1enteev7	132	7	to	to	TO
cord-350836-1enteev7	132	8	be	be	VB
cord-350836-1enteev7	132	9	essential	essential	JJ
cord-350836-1enteev7	132	10	for	for	IN
cord-350836-1enteev7	132	11	MDA5	mda5	JJ
cord-350836-1enteev7	132	12	activation	activation	NN
cord-350836-1enteev7	132	13	by	by	IN
cord-350836-1enteev7	132	14	K63	K63	NNP
cord-350836-1enteev7	132	15	polyubiquitination	polyubiquitination	NN
cord-350836-1enteev7	132	16	at	at	IN
cord-350836-1enteev7	132	17	K743	k743	ADD
cord-350836-1enteev7	132	18	(	(	-LRB-
cord-350836-1enteev7	132	19	127	127	CD
cord-350836-1enteev7	132	20	)	)	-RRB-
cord-350836-1enteev7	132	21	.	.	.
cord-350836-1enteev7	133	1	It	-PRON-	PRP
cord-350836-1enteev7	133	2	is	be	VBZ
cord-350836-1enteev7	133	3	clear	clear	JJ
cord-350836-1enteev7	133	4	that	that	IN
cord-350836-1enteev7	133	5	additional	additional	JJ
cord-350836-1enteev7	133	6	studies	study	NNS
cord-350836-1enteev7	133	7	are	be	VBP
cord-350836-1enteev7	133	8	needed	need	VBN
cord-350836-1enteev7	133	9	in	in	IN
cord-350836-1enteev7	133	10	order	order	NN
cord-350836-1enteev7	133	11	to	to	TO
cord-350836-1enteev7	133	12	clarify	clarify	VB
cord-350836-1enteev7	133	13	the	the	DT
cord-350836-1enteev7	133	14	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	133	15	mechanisms	mechanism	NNS
cord-350836-1enteev7	133	16	of	of	IN
cord-350836-1enteev7	133	17	MDA5	MDA5	NNP
cord-350836-1enteev7	133	18	.	.	.
cord-350836-1enteev7	134	1	Upon	upon	IN
cord-350836-1enteev7	134	2	binding	bind	VBG
cord-350836-1enteev7	134	3	to	to	IN
cord-350836-1enteev7	134	4	PAMP	PAMP	NNP
cord-350836-1enteev7	134	5	(	(	-LRB-
cord-350836-1enteev7	134	6	dsRNA	dsrna	NN
cord-350836-1enteev7	134	7	)	)	-RRB-
cord-350836-1enteev7	134	8	,	,	,
cord-350836-1enteev7	134	9	RIG	rig	NN
cord-350836-1enteev7	134	10	-	-	:
cord-350836-1enteev7	134	11	I	-PRON-	PRP
cord-350836-1enteev7	134	12	oligomerizes	oligomerizes	VBP
cord-350836-1enteev7	134	13	with	with	IN
cord-350836-1enteev7	134	14	other	other	JJ
cord-350836-1enteev7	134	15	RIG	rig	NN
cord-350836-1enteev7	134	16	-	-	HYPH
cord-350836-1enteev7	134	17	I	I	NNP
cord-350836-1enteev7	134	18	/	/	,
cord-350836-1enteev7	134	19	dsRNA	dsrna	NN
cord-350836-1enteev7	134	20	complexes	complex	NNS
cord-350836-1enteev7	134	21	to	to	TO
cord-350836-1enteev7	134	22	form	form	VB
cord-350836-1enteev7	134	23	helical	helical	JJ
cord-350836-1enteev7	134	24	oligomers	oligomer	NNS
cord-350836-1enteev7	134	25	(	(	-LRB-
cord-350836-1enteev7	134	26	128	128	CD
cord-350836-1enteev7	134	27	)	)	-RRB-
cord-350836-1enteev7	134	28	in	in	IN
cord-350836-1enteev7	134	29	a	a	DT
cord-350836-1enteev7	134	30	2:2	2:2	CD
cord-350836-1enteev7	134	31	complex	complex	NN
cord-350836-1enteev7	134	32	using	use	VBG
cord-350836-1enteev7	134	33	the	the	DT
cord-350836-1enteev7	134	34	purified	purify	VBN
cord-350836-1enteev7	134	35	RIG	rig	NN
cord-350836-1enteev7	134	36	-	-	:
cord-350836-1enteev7	134	37	I	i	NN
cord-350836-1enteev7	134	38	protein	protein	NN
cord-350836-1enteev7	134	39	(	(	-LRB-
cord-350836-1enteev7	134	40	87	87	CD
cord-350836-1enteev7	134	41	)	)	-RRB-
cord-350836-1enteev7	134	42	,	,	,
cord-350836-1enteev7	134	43	where	where	WRB
cord-350836-1enteev7	134	44	the	the	DT
cord-350836-1enteev7	134	45	activating	activate	VBG
cord-350836-1enteev7	134	46	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	134	47	motifs	motif	NNS
cord-350836-1enteev7	134	48	serve	serve	VBP
cord-350836-1enteev7	134	49	as	as	IN
cord-350836-1enteev7	134	50	a	a	DT
cord-350836-1enteev7	134	51	scaffold	scaffold	NN
cord-350836-1enteev7	134	52	to	to	TO
cord-350836-1enteev7	134	53	link	link	VB
cord-350836-1enteev7	134	54	the	the	DT
cord-350836-1enteev7	134	55	oligomers	oligomer	NNS
cord-350836-1enteev7	134	56	together	together	RB
cord-350836-1enteev7	134	57	(	(	-LRB-
cord-350836-1enteev7	134	58	118	118	CD
cord-350836-1enteev7	134	59	)	)	-RRB-
cord-350836-1enteev7	134	60	.	.	.
cord-350836-1enteev7	135	1	These	these	DT
cord-350836-1enteev7	135	2	oligomers	oligomer	NNS
cord-350836-1enteev7	135	3	have	have	VBP
cord-350836-1enteev7	135	4	been	be	VBN
cord-350836-1enteev7	135	5	found	find	VBN
cord-350836-1enteev7	135	6	to	to	TO
cord-350836-1enteev7	135	7	be	be	VB
cord-350836-1enteev7	135	8	necessary	necessary	JJ
cord-350836-1enteev7	135	9	under	under	IN
cord-350836-1enteev7	135	10	normal	normal	JJ
cord-350836-1enteev7	135	11	conditions	condition	NNS
cord-350836-1enteev7	135	12	to	to	TO
cord-350836-1enteev7	135	13	activate	activate	VB
cord-350836-1enteev7	135	14	RIG	rig	NN
cord-350836-1enteev7	135	15	-	-	HYPH
cord-350836-1enteev7	135	16	I.	i.	NN
cord-350836-1enteev7	136	1	This	this	DT
cord-350836-1enteev7	136	2	may	may	MD
cord-350836-1enteev7	136	3	be	be	VB
cord-350836-1enteev7	136	4	due	due	JJ
cord-350836-1enteev7	136	5	to	to	IN
cord-350836-1enteev7	136	6	the	the	DT
cord-350836-1enteev7	136	7	helical	helical	JJ
cord-350836-1enteev7	136	8	structure	structure	NN
cord-350836-1enteev7	136	9	of	of	IN
cord-350836-1enteev7	136	10	the	the	DT
cord-350836-1enteev7	136	11	RIG	rig	NN
cord-350836-1enteev7	136	12	-	-	:
cord-350836-1enteev7	136	13	I	-PRON-	PRP
cord-350836-1enteev7	136	14	oligomers	oligomer	NNS
cord-350836-1enteev7	136	15	closely	closely	RB
cord-350836-1enteev7	136	16	matching	match	VBG
cord-350836-1enteev7	136	17	those	those	DT
cord-350836-1enteev7	136	18	formed	form	VBN
cord-350836-1enteev7	136	19	by	by	IN
cord-350836-1enteev7	136	20	MAVS	MAVS	NNPS
cord-350836-1enteev7	136	21	(	(	-LRB-
cord-350836-1enteev7	136	22	63	63	CD
cord-350836-1enteev7	136	23	)	)	-RRB-
cord-350836-1enteev7	136	24	,	,	,
cord-350836-1enteev7	136	25	which	which	WDT
cord-350836-1enteev7	136	26	is	be	VBZ
cord-350836-1enteev7	136	27	known	know	VBN
cord-350836-1enteev7	136	28	to	to	TO
cord-350836-1enteev7	136	29	form	form	VB
cord-350836-1enteev7	136	30	filaments	filament	NNS
cord-350836-1enteev7	136	31	in	in	IN
cord-350836-1enteev7	136	32	-	-	HYPH
cord-350836-1enteev7	136	33	vitro	vitro	FW
cord-350836-1enteev7	136	34	(	(	-LRB-
cord-350836-1enteev7	136	35	129	129	CD
cord-350836-1enteev7	136	36	,	,	,
cord-350836-1enteev7	136	37	130	130	CD
cord-350836-1enteev7	136	38	)	)	-RRB-
cord-350836-1enteev7	136	39	mediated	mediate	VBN
cord-350836-1enteev7	136	40	by	by	IN
cord-350836-1enteev7	136	41	its	-PRON-	PRP$
cord-350836-1enteev7	136	42	own	own	JJ
cord-350836-1enteev7	136	43	CARD	card	NN
cord-350836-1enteev7	136	44	domains	domain	NNS
cord-350836-1enteev7	136	45	(	(	-LRB-
cord-350836-1enteev7	136	46	131	131	CD
cord-350836-1enteev7	136	47	,	,	,
cord-350836-1enteev7	136	48	132	132	CD
cord-350836-1enteev7	136	49	)	)	-RRB-
cord-350836-1enteev7	136	50	.	.	.
cord-350836-1enteev7	137	1	A	a	DT
cord-350836-1enteev7	137	2	structural	structural	JJ
cord-350836-1enteev7	137	3	model	model	NN
cord-350836-1enteev7	137	4	of	of	IN
cord-350836-1enteev7	137	5	MAVS	MAVS	NNP
cord-350836-1enteev7	137	6	activation	activation	NN
cord-350836-1enteev7	137	7	by	by	IN
cord-350836-1enteev7	137	8	RIG	rig	NN
cord-350836-1enteev7	137	9	-	-	:
cord-350836-1enteev7	137	10	I	-PRON-	PRP
cord-350836-1enteev7	137	11	has	have	VBZ
cord-350836-1enteev7	137	12	been	be	VBN
cord-350836-1enteev7	137	13	proposed	propose	VBN
cord-350836-1enteev7	137	14	of	of	IN
cord-350836-1enteev7	137	15	stacking	stack	VBG
cord-350836-1enteev7	137	16	MAVS	MAVS	NNP
cord-350836-1enteev7	137	17	CARD	card	NN
cord-350836-1enteev7	137	18	domains	domain	NNS
cord-350836-1enteev7	137	19	on	on	IN
cord-350836-1enteev7	137	20	top	top	NN
cord-350836-1enteev7	137	21	of	of	IN
cord-350836-1enteev7	137	22	RIG-	rig-	NN
cord-350836-1enteev7	138	1	I	-PRON-	PRP
cord-350836-1enteev7	138	2	CARD	card	VBP
cord-350836-1enteev7	138	3	domains	domain	NNS
cord-350836-1enteev7	138	4	to	to	TO
cord-350836-1enteev7	138	5	extend	extend	VB
cord-350836-1enteev7	138	6	the	the	DT
cord-350836-1enteev7	138	7	RIG	rig	NN
cord-350836-1enteev7	138	8	-	-	:
cord-350836-1enteev7	138	9	I	-PRON-	PRP
cord-350836-1enteev7	138	10	helix	helix	NN
cord-350836-1enteev7	138	11	(	(	-LRB-
cord-350836-1enteev7	138	12	133	133	CD
cord-350836-1enteev7	138	13	)	)	-RRB-
cord-350836-1enteev7	138	14	.	.	.
cord-350836-1enteev7	139	1	The	the	DT
cord-350836-1enteev7	139	2	minimum	minimum	JJ
cord-350836-1enteev7	139	3	length	length	NN
cord-350836-1enteev7	139	4	of	of	IN
cord-350836-1enteev7	139	5	dsRNA	dsrna	NN
cord-350836-1enteev7	139	6	found	find	VBN
cord-350836-1enteev7	139	7	to	to	TO
cord-350836-1enteev7	139	8	activate	activate	VB
cord-350836-1enteev7	139	9	RIG	rig	NN
cord-350836-1enteev7	140	1	-I	-I	NNP
cord-350836-1enteev7	140	2	is	be	VBZ
cord-350836-1enteev7	140	3	13	13	CD
cord-350836-1enteev7	140	4	base	base	NN
cord-350836-1enteev7	140	5	pairs	pair	NNS
cord-350836-1enteev7	140	6	,	,	,
cord-350836-1enteev7	140	7	which	which	WDT
cord-350836-1enteev7	140	8	is	be	VBZ
cord-350836-1enteev7	140	9	equivalent	equivalent	JJ
cord-350836-1enteev7	140	10	to	to	IN
cord-350836-1enteev7	140	11	the	the	DT
cord-350836-1enteev7	140	12	minimum	minimum	JJ
cord-350836-1enteev7	140	13	length	length	NN
cord-350836-1enteev7	140	14	to	to	TO
cord-350836-1enteev7	140	15	facilitate	facilitate	VB
cord-350836-1enteev7	140	16	the	the	DT
cord-350836-1enteev7	140	17	formation	formation	NN
cord-350836-1enteev7	140	18	of	of	IN
cord-350836-1enteev7	140	19	a	a	DT
cord-350836-1enteev7	140	20	2-RIG	2-rig	CD
cord-350836-1enteev7	140	21	-	-	HYPH
cord-350836-1enteev7	140	22	I	I	NNP
cord-350836-1enteev7	140	23	/	/	SYM
cord-350836-1enteev7	140	24	dsRNA	dsrna	NN
cord-350836-1enteev7	140	25	dimer	dimer	NN
cord-350836-1enteev7	140	26	(	(	-LRB-
cord-350836-1enteev7	140	27	75	75	CD
cord-350836-1enteev7	140	28	)	)	-RRB-
cord-350836-1enteev7	140	29	.	.	.
cord-350836-1enteev7	141	1	That	that	DT
cord-350836-1enteev7	141	2	being	be	VBG
cord-350836-1enteev7	141	3	said	say	VBN
cord-350836-1enteev7	141	4	,	,	,
cord-350836-1enteev7	141	5	shorter	short	JJR
cord-350836-1enteev7	141	6	(	(	-LRB-
cord-350836-1enteev7	141	7	∼10	∼10	NNP
cord-350836-1enteev7	141	8	bp	bp	NNP
cord-350836-1enteev7	141	9	)	)	-RRB-
cord-350836-1enteev7	142	1	5	5	LS
cord-350836-1enteev7	142	2	′	′	CD
cord-350836-1enteev7	142	3	ppp	ppp	NNP
cord-350836-1enteev7	142	4	stem	stem	NN
cord-350836-1enteev7	142	5	loop	loop	NNP
cord-350836-1enteev7	142	6	dsRNA	dsrna	NN
cord-350836-1enteev7	142	7	complexes	complex	NNS
cord-350836-1enteev7	142	8	that	that	WDT
cord-350836-1enteev7	142	9	have	have	VBP
cord-350836-1enteev7	142	10	previously	previously	RB
cord-350836-1enteev7	142	11	been	be	VBN
cord-350836-1enteev7	142	12	used	use	VBN
cord-350836-1enteev7	142	13	to	to	TO
cord-350836-1enteev7	142	14	obtain	obtain	VB
cord-350836-1enteev7	142	15	X	x	NN
cord-350836-1enteev7	142	16	-	-	NN
cord-350836-1enteev7	142	17	ray	ray	NN
cord-350836-1enteev7	142	18	crystallographic	crystallographic	JJ
cord-350836-1enteev7	142	19	structures	structure	NNS
cord-350836-1enteev7	142	20	of	of	IN
cord-350836-1enteev7	142	21	RIG	rig	NN
cord-350836-1enteev7	143	1	-I	-i	WDT
cord-350836-1enteev7	143	2	interacting	interact	VBG
cord-350836-1enteev7	143	3	with	with	IN
cord-350836-1enteev7	143	4	dsRNA	dsRNA	NNS
cord-350836-1enteev7	143	5	(	(	-LRB-
cord-350836-1enteev7	143	6	61	61	CD
cord-350836-1enteev7	143	7	,	,	,
cord-350836-1enteev7	143	8	134	134	CD
cord-350836-1enteev7	143	9	,	,	,
cord-350836-1enteev7	143	10	135	135	CD
cord-350836-1enteev7	143	11	)	)	-RRB-
cord-350836-1enteev7	143	12	(	(	-LRB-
cord-350836-1enteev7	143	13	Figure	figure	NN
cord-350836-1enteev7	143	14	3C	3c	NN
cord-350836-1enteev7	143	15	)	)	-RRB-
cord-350836-1enteev7	143	16	can	can	MD
cord-350836-1enteev7	143	17	also	also	RB
cord-350836-1enteev7	143	18	activate	activate	VB
cord-350836-1enteev7	143	19	IFNβ	IFNβ	NNS
cord-350836-1enteev7	143	20	signaling	signal	VBG
cord-350836-1enteev7	143	21	in	in	IN
cord-350836-1enteev7	143	22	cells	cell	NNS
cord-350836-1enteev7	143	23	(	(	-LRB-
cord-350836-1enteev7	143	24	135	135	CD
cord-350836-1enteev7	143	25	,	,	,
cord-350836-1enteev7	143	26	136	136	CD
cord-350836-1enteev7	143	27	)	)	-RRB-
cord-350836-1enteev7	143	28	and	and	CC
cord-350836-1enteev7	143	29	in	in	IN
cord-350836-1enteev7	143	30	mice	mouse	NNS
cord-350836-1enteev7	143	31	(	(	-LRB-
cord-350836-1enteev7	143	32	136	136	CD
cord-350836-1enteev7	143	33	)	)	-RRB-
cord-350836-1enteev7	143	34	.	.	.
cord-350836-1enteev7	144	1	Furthermore	furthermore	RB
cord-350836-1enteev7	144	2	,	,	,
cord-350836-1enteev7	144	3	A549	a549	JJ
cord-350836-1enteev7	144	4	cells	cell	NNS
cord-350836-1enteev7	144	5	that	that	WDT
cord-350836-1enteev7	144	6	were	be	VBD
cord-350836-1enteev7	144	7	transfected	transfecte	VBN
cord-350836-1enteev7	144	8	with	with	IN
cord-350836-1enteev7	144	9	RIG	rig	NN
cord-350836-1enteev7	144	10	-	-	:
cord-350836-1enteev7	144	11	I	i	NN
cord-350836-1enteev7	144	12	plasmid	plasmid	NN
cord-350836-1enteev7	144	13	6	6	CD
cord-350836-1enteev7	144	14	h	h	NN
cord-350836-1enteev7	144	15	prior	prior	RB
cord-350836-1enteev7	144	16	to	to	IN
cord-350836-1enteev7	144	17	RNA	RNA	NNP
cord-350836-1enteev7	144	18	transfection	transfection	NN
cord-350836-1enteev7	144	19	had	have	VBD
cord-350836-1enteev7	144	20	a	a	DT
cord-350836-1enteev7	144	21	minimum	minimum	JJ
cord-350836-1enteev7	144	22	dsRNA	dsrna	JJ
cord-350836-1enteev7	144	23	length	length	NN
cord-350836-1enteev7	144	24	of	of	IN
cord-350836-1enteev7	144	25	only	only	RB
cord-350836-1enteev7	144	26	8	8	CD
cord-350836-1enteev7	144	27	-	-	SYM
cord-350836-1enteev7	144	28	10	10	CD
cord-350836-1enteev7	144	29	bp	bp	NNP
cord-350836-1enteev7	144	30	required	require	VBN
cord-350836-1enteev7	144	31	for	for	IN
cord-350836-1enteev7	144	32	activation	activation	NN
cord-350836-1enteev7	144	33	(	(	-LRB-
cord-350836-1enteev7	144	34	75	75	CD
cord-350836-1enteev7	144	35	)	)	-RRB-
cord-350836-1enteev7	144	36	.	.	.
cord-350836-1enteev7	145	1	This	this	DT
cord-350836-1enteev7	145	2	indicates	indicate	VBZ
cord-350836-1enteev7	145	3	that	that	IN
cord-350836-1enteev7	145	4	RIG	rig	NN
cord-350836-1enteev7	145	5	-	-	:
cord-350836-1enteev7	145	6	I	i	NN
cord-350836-1enteev7	145	7	oligomerization	oligomerization	NN
cord-350836-1enteev7	145	8	may	may	MD
cord-350836-1enteev7	145	9	not	not	RB
cord-350836-1enteev7	145	10	be	be	VB
cord-350836-1enteev7	145	11	necessary	necessary	JJ
cord-350836-1enteev7	145	12	for	for	IN
cord-350836-1enteev7	145	13	activation	activation	NN
cord-350836-1enteev7	145	14	of	of	IN
cord-350836-1enteev7	145	15	the	the	DT
cord-350836-1enteev7	145	16	IFNβ	IFNβ	NNS
cord-350836-1enteev7	145	17	pathway	pathway	NN
cord-350836-1enteev7	145	18	under	under	IN
cord-350836-1enteev7	145	19	some	some	DT
cord-350836-1enteev7	145	20	experimental	experimental	JJ
cord-350836-1enteev7	145	21	conditions	condition	NNS
cord-350836-1enteev7	145	22	,	,	,
cord-350836-1enteev7	145	23	which	which	WDT
cord-350836-1enteev7	145	24	need	need	VBP
cord-350836-1enteev7	145	25	to	to	TO
cord-350836-1enteev7	145	26	be	be	VB
cord-350836-1enteev7	145	27	further	further	RB
cord-350836-1enteev7	145	28	investigated	investigate	VBN
cord-350836-1enteev7	145	29	.	.	.
cord-350836-1enteev7	146	1	MDA5	MDA5	NNP
cord-350836-1enteev7	146	2	has	have	VBZ
cord-350836-1enteev7	146	3	also	also	RB
cord-350836-1enteev7	146	4	been	be	VBN
cord-350836-1enteev7	146	5	shown	show	VBN
cord-350836-1enteev7	146	6	to	to	IN
cord-350836-1enteev7	146	7	oligomerize	oligomerize	NNP
cord-350836-1enteev7	146	8	to	to	TO
cord-350836-1enteev7	146	9	form	form	VB
cord-350836-1enteev7	146	10	long	long	JJ
cord-350836-1enteev7	146	11	RNAassociated	rnaassociate	VBN
cord-350836-1enteev7	146	12	filaments	filament	NNS
cord-350836-1enteev7	146	13	in	in	IN
cord-350836-1enteev7	146	14	vitro	vitro	FW
cord-350836-1enteev7	146	15	(	(	-LRB-
cord-350836-1enteev7	146	16	62	62	CD
cord-350836-1enteev7	146	17	,	,	,
cord-350836-1enteev7	146	18	137	137	CD
cord-350836-1enteev7	146	19	,	,	,
cord-350836-1enteev7	146	20	138	138	CD
cord-350836-1enteev7	146	21	)	)	-RRB-
cord-350836-1enteev7	147	1	(	(	-LRB-
cord-350836-1enteev7	147	2	Figures	figure	NNS
cord-350836-1enteev7	147	3	3D	3d	JJ
cord-350836-1enteev7	147	4	,	,	,
cord-350836-1enteev7	147	5	4H	4H	NNP
cord-350836-1enteev7	147	6	)	)	-RRB-
cord-350836-1enteev7	147	7	,	,	,
cord-350836-1enteev7	147	8	which	which	WDT
cord-350836-1enteev7	147	9	may	may	MD
cord-350836-1enteev7	147	10	be	be	VB
cord-350836-1enteev7	147	11	aided	aid	VBN
cord-350836-1enteev7	147	12	by	by	IN
cord-350836-1enteev7	147	13	chaperone	chaperone	NN
cord-350836-1enteev7	147	14	proteins	protein	NNS
cord-350836-1enteev7	147	15	(	(	-LRB-
cord-350836-1enteev7	147	16	139	139	CD
cord-350836-1enteev7	147	17	)	)	-RRB-
cord-350836-1enteev7	147	18	.	.	.
cord-350836-1enteev7	148	1	Given	give	VBN
cord-350836-1enteev7	148	2	that	that	IN
cord-350836-1enteev7	148	3	the	the	DT
cord-350836-1enteev7	148	4	K743	K743	NNP
cord-350836-1enteev7	148	5	residue	residue	NN
cord-350836-1enteev7	148	6	found	find	VBN
cord-350836-1enteev7	148	7	to	to	TO
cord-350836-1enteev7	148	8	have	have	VB
cord-350836-1enteev7	148	9	been	be	VBN
cord-350836-1enteev7	148	10	ubiquitinated	ubiquitinate	VBN
cord-350836-1enteev7	148	11	by	by	IN
cord-350836-1enteev7	148	12	TRIM65	TRIM65	NNP
cord-350836-1enteev7	148	13	(	(	-LRB-
cord-350836-1enteev7	148	14	127	127	CD
cord-350836-1enteev7	148	15	)	)	-RRB-
cord-350836-1enteev7	148	16	is	be	VBZ
cord-350836-1enteev7	148	17	located	locate	VBN
cord-350836-1enteev7	148	18	on	on	IN
cord-350836-1enteev7	148	19	the	the	DT
cord-350836-1enteev7	148	20	surface	surface	NN
cord-350836-1enteev7	148	21	of	of	IN
cord-350836-1enteev7	148	22	Hel2	Hel2	NNP
cord-350836-1enteev7	148	23	,	,	,
cord-350836-1enteev7	148	24	it	-PRON-	PRP
cord-350836-1enteev7	148	25	is	be	VBZ
cord-350836-1enteev7	148	26	possible	possible	JJ
cord-350836-1enteev7	148	27	that	that	IN
cord-350836-1enteev7	148	28	K63	K63	NNP
cord-350836-1enteev7	148	29	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	148	30	residues	residue	NNS
cord-350836-1enteev7	148	31	may	may	MD
cord-350836-1enteev7	148	32	also	also	RB
cord-350836-1enteev7	148	33	help	help	VB
cord-350836-1enteev7	148	34	stabilize	stabilize	VB
cord-350836-1enteev7	148	35	MDA5-dsRNA	mda5-dsrna	IN
cord-350836-1enteev7	148	36	filaments	filament	NNS
cord-350836-1enteev7	148	37	(	(	-LRB-
cord-350836-1enteev7	148	38	140	140	CD
cord-350836-1enteev7	148	39	)	)	-RRB-
cord-350836-1enteev7	148	40	.	.	.
cord-350836-1enteev7	149	1	However	however	RB
cord-350836-1enteev7	149	2	,	,	,
cord-350836-1enteev7	149	3	MDA5	MDA5	NNP
cord-350836-1enteev7	149	4	also	also	RB
cord-350836-1enteev7	149	5	spontaneously	spontaneously	RB
cord-350836-1enteev7	149	6	forms	form	VBZ
cord-350836-1enteev7	149	7	filaments	filament	NNS
cord-350836-1enteev7	149	8	and	and	CC
cord-350836-1enteev7	149	9	induce	induce	VB
cord-350836-1enteev7	149	10	MAVS	MAVS	NNP
cord-350836-1enteev7	149	11	to	to	TO
cord-350836-1enteev7	149	12	form	form	VB
cord-350836-1enteev7	149	13	filaments	filament	NNS
cord-350836-1enteev7	149	14	independently	independently	RB
cord-350836-1enteev7	149	15	of	of	IN
cord-350836-1enteev7	149	16	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	149	17	in	in	NN
cord-350836-1enteev7	149	18	-	-	HYPH
cord-350836-1enteev7	149	19	situ	situ	NN
cord-350836-1enteev7	149	20	.	.	.
cord-350836-1enteev7	150	1	It	-PRON-	PRP
cord-350836-1enteev7	150	2	is	be	VBZ
cord-350836-1enteev7	150	3	also	also	RB
cord-350836-1enteev7	150	4	thought	think	VBN
cord-350836-1enteev7	150	5	that	that	IN
cord-350836-1enteev7	150	6	the	the	DT
cord-350836-1enteev7	150	7	formation	formation	NN
cord-350836-1enteev7	150	8	of	of	IN
cord-350836-1enteev7	150	9	longer	long	JJR
cord-350836-1enteev7	150	10	filaments	filament	NNS
cord-350836-1enteev7	150	11	by	by	IN
cord-350836-1enteev7	150	12	MDA5	MDA5	NNP
cord-350836-1enteev7	150	13	may	may	MD
cord-350836-1enteev7	150	14	be	be	VB
cord-350836-1enteev7	150	15	mediated	mediate	VBN
cord-350836-1enteev7	150	16	by	by	IN
cord-350836-1enteev7	150	17	a	a	DT
cord-350836-1enteev7	150	18	longer	long	JJR
cord-350836-1enteev7	150	19	linkage	linkage	NN
cord-350836-1enteev7	150	20	region	region	NN
cord-350836-1enteev7	150	21	between	between	IN
cord-350836-1enteev7	150	22	CARD2	CARD2	NNS
cord-350836-1enteev7	150	23	and	and	CC
cord-350836-1enteev7	150	24	Hel1	Hel1	NNP
cord-350836-1enteev7	150	25	than	than	IN
cord-350836-1enteev7	150	26	in	in	IN
cord-350836-1enteev7	150	27	RIG	rig	NN
cord-350836-1enteev7	150	28	-	-	:
cord-350836-1enteev7	150	29	I	i	NN
cord-350836-1enteev7	150	30	by	by	IN
cord-350836-1enteev7	150	31	50	50	CD
cord-350836-1enteev7	150	32	amino	amino	NN
cord-350836-1enteev7	150	33	acids	acid	NNS
cord-350836-1enteev7	150	34	(	(	-LRB-
cord-350836-1enteev7	150	35	the	the	DT
cord-350836-1enteev7	150	36	length	length	NN
cord-350836-1enteev7	150	37	of	of	IN
cord-350836-1enteev7	150	38	which	which	WDT
cord-350836-1enteev7	150	39	is	be	VBZ
cord-350836-1enteev7	150	40	wellconserved	wellconserve	VBN
cord-350836-1enteev7	150	41	across	across	IN
cord-350836-1enteev7	150	42	species	specie	NNS
cord-350836-1enteev7	150	43	)	)	-RRB-
cord-350836-1enteev7	150	44	,	,	,
cord-350836-1enteev7	150	45	allowing	allow	VBG
cord-350836-1enteev7	150	46	for	for	IN
cord-350836-1enteev7	150	47	the	the	DT
cord-350836-1enteev7	150	48	association	association	NN
cord-350836-1enteev7	150	49	of	of	IN
cord-350836-1enteev7	150	50	more	more	JJR
cord-350836-1enteev7	150	51	CARD	card	NN
cord-350836-1enteev7	150	52	domains	domain	NNS
cord-350836-1enteev7	150	53	in	in	IN
cord-350836-1enteev7	150	54	an	an	DT
cord-350836-1enteev7	150	55	oligomer	oligomer	NN
cord-350836-1enteev7	150	56	(	(	-LRB-
cord-350836-1enteev7	150	57	133	133	CD
cord-350836-1enteev7	150	58	)	)	-RRB-
cord-350836-1enteev7	150	59	.	.	.
cord-350836-1enteev7	151	1	The	the	DT
cord-350836-1enteev7	151	2	formation	formation	NN
cord-350836-1enteev7	151	3	of	of	IN
cord-350836-1enteev7	151	4	longer	long	JJR
cord-350836-1enteev7	151	5	filaments	filament	NNS
cord-350836-1enteev7	151	6	by	by	IN
cord-350836-1enteev7	151	7	RIG	rig	NN
cord-350836-1enteev7	151	8	-	-	:
cord-350836-1enteev7	151	9	I	-PRON-	PRP
cord-350836-1enteev7	151	10	has	have	VBZ
cord-350836-1enteev7	151	11	been	be	VBN
cord-350836-1enteev7	151	12	more	more	RBR
cord-350836-1enteev7	151	13	controversial	controversial	JJ
cord-350836-1enteev7	151	14	,	,	,
cord-350836-1enteev7	151	15	giving	give	VBG
cord-350836-1enteev7	151	16	rise	rise	NN
cord-350836-1enteev7	151	17	to	to	IN
cord-350836-1enteev7	151	18	two	two	CD
cord-350836-1enteev7	151	19	alternate	alternate	JJ
cord-350836-1enteev7	151	20	models	model	NNS
cord-350836-1enteev7	151	21	of	of	IN
cord-350836-1enteev7	151	22	RIG	rig	NN
cord-350836-1enteev7	151	23	-	-	:
cord-350836-1enteev7	151	24	I	-PRON-	PRP
cord-350836-1enteev7	151	25	activation	activation	NN
cord-350836-1enteev7	151	26	:	:	:
cord-350836-1enteev7	151	27	formation	formation	NN
cord-350836-1enteev7	151	28	of	of	IN
cord-350836-1enteev7	151	29	individual	individual	JJ
cord-350836-1enteev7	151	30	single	single	JJ
cord-350836-1enteev7	151	31	unit	unit	NN
cord-350836-1enteev7	151	32	of	of	IN
cord-350836-1enteev7	151	33	RIG	rig	NN
cord-350836-1enteev7	151	34	-	-	:
cord-350836-1enteev7	151	35	I	-PRON-	PRP
cord-350836-1enteev7	151	36	with	with	IN
cord-350836-1enteev7	151	37	short	short	JJ
cord-350836-1enteev7	151	38	dsRNA	dsrna	NN
cord-350836-1enteev7	151	39	monomers	monomer	NNS
cord-350836-1enteev7	151	40	(	(	-LRB-
cord-350836-1enteev7	151	41	leaving	leave	VBG
cord-350836-1enteev7	151	42	a	a	DT
cord-350836-1enteev7	151	43	free	free	JJ
cord-350836-1enteev7	151	44	dsRNA	dsrna	JJ
cord-350836-1enteev7	151	45	end	end	NN
cord-350836-1enteev7	151	46	,	,	,
cord-350836-1enteev7	151	47	such	such	JJ
cord-350836-1enteev7	151	48	as	as	IN
cord-350836-1enteev7	151	49	a	a	DT
cord-350836-1enteev7	151	50	hairpin	hairpin	NN
cord-350836-1enteev7	151	51	loop	loop	NN
cord-350836-1enteev7	151	52	)	)	-RRB-
cord-350836-1enteev7	151	53	,	,	,
cord-350836-1enteev7	151	54	which	which	WDT
cord-350836-1enteev7	151	55	then	then	RB
cord-350836-1enteev7	151	56	oligomerizes	oligomerize	VBZ
cord-350836-1enteev7	151	57	via	via	IN
cord-350836-1enteev7	151	58	CARD	card	NN
cord-350836-1enteev7	151	59	tetramerization	tetramerization	NN
cord-350836-1enteev7	151	60	that	that	WDT
cord-350836-1enteev7	151	61	is	be	VBZ
cord-350836-1enteev7	151	62	linked	link	VBN
cord-350836-1enteev7	151	63	by	by	IN
cord-350836-1enteev7	151	64	their	-PRON-	PRP$
cord-350836-1enteev7	151	65	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	151	66	chains	chain	NNS
cord-350836-1enteev7	151	67	,	,	,
cord-350836-1enteev7	151	68	or	or	CC
cord-350836-1enteev7	151	69	filamentation	filamentation	NN
cord-350836-1enteev7	151	70	on	on	IN
cord-350836-1enteev7	151	71	longer	long	JJR
cord-350836-1enteev7	151	72	dsRNA	dsrna	NN
cord-350836-1enteev7	151	73	.	.	.
cord-350836-1enteev7	152	1	Like	like	IN
cord-350836-1enteev7	152	2	MDA5	MDA5	NNP
cord-350836-1enteev7	152	3	,	,	,
cord-350836-1enteev7	152	4	RIG	rig	NN
cord-350836-1enteev7	152	5	-	-	:
cord-350836-1enteev7	152	6	I	-PRON-	PRP
cord-350836-1enteev7	152	7	can	can	MD
cord-350836-1enteev7	152	8	form	form	VB
cord-350836-1enteev7	152	9	filaments	filament	NNS
cord-350836-1enteev7	152	10	in	in	IN
cord-350836-1enteev7	152	11	-	-	HYPH
cord-350836-1enteev7	152	12	situ	situ	NN
cord-350836-1enteev7	152	13	independent	independent	NN
cord-350836-1enteev7	152	14	of	of	IN
cord-350836-1enteev7	152	15	ubiquitin	ubiquitin	NNP
cord-350836-1enteev7	152	16	(	(	-LRB-
cord-350836-1enteev7	152	17	141	141	CD
cord-350836-1enteev7	152	18	,	,	,
cord-350836-1enteev7	152	19	142	142	CD
cord-350836-1enteev7	152	20	)	)	-RRB-
cord-350836-1enteev7	152	21	and	and	CC
cord-350836-1enteev7	152	22	induces	induce	VBZ
cord-350836-1enteev7	152	23	MAVS	MAVS	NNP
cord-350836-1enteev7	152	24	to	to	TO
cord-350836-1enteev7	152	25	also	also	RB
cord-350836-1enteev7	152	26	form	form	VB
cord-350836-1enteev7	152	27	filaments	filament	NNS
cord-350836-1enteev7	152	28	(	(	-LRB-
cord-350836-1enteev7	152	29	142	142	CD
cord-350836-1enteev7	152	30	)	)	-RRB-
cord-350836-1enteev7	152	31	,	,	,
cord-350836-1enteev7	152	32	and	and	CC
cord-350836-1enteev7	152	33	MAVS	MAVS	NNP
cord-350836-1enteev7	152	34	is	be	VBZ
cord-350836-1enteev7	152	35	known	know	VBN
cord-350836-1enteev7	152	36	to	to	TO
cord-350836-1enteev7	152	37	form	form	VB
cord-350836-1enteev7	152	38	filaments	filament	NNS
cord-350836-1enteev7	152	39	in	in	IN
cord-350836-1enteev7	152	40	-	-	HYPH
cord-350836-1enteev7	152	41	vitro	vitro	FW
cord-350836-1enteev7	152	42	(	(	-LRB-
cord-350836-1enteev7	152	43	129	129	CD
cord-350836-1enteev7	152	44	,	,	,
cord-350836-1enteev7	152	45	130	130	CD
cord-350836-1enteev7	152	46	)	)	-RRB-
cord-350836-1enteev7	152	47	mediated	mediate	VBN
cord-350836-1enteev7	152	48	by	by	IN
cord-350836-1enteev7	152	49	its	-PRON-	PRP$
cord-350836-1enteev7	152	50	own	own	JJ
cord-350836-1enteev7	152	51	CARD	card	NN
cord-350836-1enteev7	152	52	domains	domain	NNS
cord-350836-1enteev7	152	53	(	(	-LRB-
cord-350836-1enteev7	152	54	131	131	CD
cord-350836-1enteev7	152	55	,	,	,
cord-350836-1enteev7	152	56	132	132	CD
cord-350836-1enteev7	152	57	)	)	-RRB-
cord-350836-1enteev7	152	58	.	.	.
cord-350836-1enteev7	153	1	However	however	RB
cord-350836-1enteev7	153	2	,	,	,
cord-350836-1enteev7	153	3	RIG	rig	NN
cord-350836-1enteev7	153	4	-	-	:
cord-350836-1enteev7	153	5	I	-PRON-	PRP
cord-350836-1enteev7	153	6	filamentation	filamentation	NN
cord-350836-1enteev7	153	7	on	on	IN
cord-350836-1enteev7	153	8	an	an	DT
cord-350836-1enteev7	153	9	RNA	RNA	NNP
cord-350836-1enteev7	153	10	template	template	NN
cord-350836-1enteev7	153	11	(	(	-LRB-
cord-350836-1enteev7	153	12	forming	form	VBG
cord-350836-1enteev7	153	13	"	"	``
cord-350836-1enteev7	153	14	beads	bead	NNS
cord-350836-1enteev7	153	15	on	on	IN
cord-350836-1enteev7	153	16	a	a	DT
cord-350836-1enteev7	153	17	string	string	NN
cord-350836-1enteev7	153	18	"	"	''
cord-350836-1enteev7	153	19	)	)	-RRB-
cord-350836-1enteev7	153	20	as	as	IN
cord-350836-1enteev7	153	21	opposed	oppose	VBN
cord-350836-1enteev7	153	22	to	to	IN
cord-350836-1enteev7	153	23	smallerscale	smallerscale	JJ
cord-350836-1enteev7	153	24	oligomerization	oligomerization	NN
cord-350836-1enteev7	153	25	has	have	VBZ
cord-350836-1enteev7	153	26	n't	not	RB
cord-350836-1enteev7	153	27	yet	yet	RB
cord-350836-1enteev7	153	28	been	be	VBN
cord-350836-1enteev7	153	29	shown	show	VBN
cord-350836-1enteev7	153	30	to	to	TO
cord-350836-1enteev7	153	31	occur	occur	VB
cord-350836-1enteev7	153	32	in	in	IN
cord-350836-1enteev7	153	33	-	-	HYPH
cord-350836-1enteev7	153	34	vitro	vitro	FW
cord-350836-1enteev7	153	35	.	.	.
cord-350836-1enteev7	154	1	Part	part	NN
cord-350836-1enteev7	154	2	of	of	IN
cord-350836-1enteev7	154	3	the	the	DT
cord-350836-1enteev7	154	4	reasons	reason	NNS
cord-350836-1enteev7	154	5	for	for	IN
cord-350836-1enteev7	154	6	the	the	DT
cord-350836-1enteev7	154	7	suggestion	suggestion	NN
cord-350836-1enteev7	154	8	that	that	IN
cord-350836-1enteev7	154	9	RIG	rig	NN
cord-350836-1enteev7	154	10	-	-	:
cord-350836-1enteev7	154	11	I	-PRON-	PRP
cord-350836-1enteev7	154	12	was	be	VBD
cord-350836-1enteev7	154	13	strongly	strongly	RB
cord-350836-1enteev7	154	14	activated	activate	VBN
cord-350836-1enteev7	154	15	by	by	IN
cord-350836-1enteev7	154	16	shorter	short	JJR
cord-350836-1enteev7	154	17	dsRNA	dsRNA	NNS
cord-350836-1enteev7	154	18	was	be	VBD
cord-350836-1enteev7	154	19	based	base	VBN
cord-350836-1enteev7	154	20	the	the	DT
cord-350836-1enteev7	154	21	comparison	comparison	NN
cord-350836-1enteev7	154	22	on	on	IN
cord-350836-1enteev7	154	23	mass	mass	JJ
cord-350836-1enteev7	154	24	equivalents	equivalent	NNS
cord-350836-1enteev7	154	25	of	of	IN
cord-350836-1enteev7	154	26	RNA	RNA	NNP
cord-350836-1enteev7	154	27	species	specie	NNS
cord-350836-1enteev7	154	28	as	as	IN
cord-350836-1enteev7	154	29	there	there	EX
cord-350836-1enteev7	154	30	were	be	VBD
cord-350836-1enteev7	155	1	less	less	JJR
cord-350836-1enteev7	155	2	5	5	CD
cord-350836-1enteev7	155	3	′	′	CD
cord-350836-1enteev7	155	4	triphosphorylated	triphosphorylate	VBN
cord-350836-1enteev7	155	5	ends	end	VBZ
cord-350836-1enteev7	155	6	for	for	IN
cord-350836-1enteev7	155	7	longer	long	JJR
cord-350836-1enteev7	155	8	dsRNAs	dsRNAs	NNP
cord-350836-1enteev7	155	9	with	with	IN
cord-350836-1enteev7	155	10	greater	great	JJR
cord-350836-1enteev7	155	11	mass	mass	NN
cord-350836-1enteev7	155	12	than	than	IN
cord-350836-1enteev7	155	13	shorter	short	JJR
cord-350836-1enteev7	155	14	dsRNAs	dsRNAs	NNP
cord-350836-1enteev7	155	15	with	with	IN
cord-350836-1enteev7	155	16	more	more	JJR
cord-350836-1enteev7	155	17	5	5	CD
cord-350836-1enteev7	155	18	′	′	CD
cord-350836-1enteev7	155	19	triphosphorylated	triphosphorylate	VBN
cord-350836-1enteev7	155	20	ends	end	VBZ
cord-350836-1enteev7	155	21	(	(	-LRB-
cord-350836-1enteev7	155	22	76	76	CD
cord-350836-1enteev7	155	23	)	)	-RRB-
cord-350836-1enteev7	155	24	.	.	.
cord-350836-1enteev7	156	1	However	however	RB
cord-350836-1enteev7	156	2	,	,	,
cord-350836-1enteev7	156	3	when	when	WRB
cord-350836-1enteev7	156	4	RNA	RNA	NNP
cord-350836-1enteev7	156	5	species	specie	NNS
cord-350836-1enteev7	156	6	were	be	VBD
cord-350836-1enteev7	156	7	normalized	normalize	VBN
cord-350836-1enteev7	156	8	by	by	IN
cord-350836-1enteev7	156	9	molar	molar	JJ
cord-350836-1enteev7	156	10	equivalence	equivalence	NN
cord-350836-1enteev7	156	11	,	,	,
cord-350836-1enteev7	156	12	dsRNA	dsrna	JJ
cord-350836-1enteev7	156	13	length	length	NN
cord-350836-1enteev7	156	14	appeared	appear	VBD
cord-350836-1enteev7	156	15	to	to	TO
cord-350836-1enteev7	156	16	be	be	VB
cord-350836-1enteev7	156	17	positively	positively	RB
cord-350836-1enteev7	156	18	correlated	correlate	VBN
cord-350836-1enteev7	156	19	with	with	IN
cord-350836-1enteev7	156	20	RIG	rig	NN
cord-350836-1enteev7	157	1	-I	-i	DT
cord-350836-1enteev7	157	2	signaling	signal	VBG
cord-350836-1enteev7	157	3	(	(	-LRB-
cord-350836-1enteev7	157	4	141	141	CD
cord-350836-1enteev7	157	5	)	)	-RRB-
cord-350836-1enteev7	157	6	(	(	-LRB-
cord-350836-1enteev7	157	7	142	142	CD
cord-350836-1enteev7	157	8	)	)	-RRB-
cord-350836-1enteev7	157	9	(	(	-LRB-
cord-350836-1enteev7	157	10	143	143	CD
cord-350836-1enteev7	157	11	)	)	-RRB-
cord-350836-1enteev7	157	12	,	,	,
cord-350836-1enteev7	157	13	which	which	WDT
cord-350836-1enteev7	157	14	became	become	VBD
cord-350836-1enteev7	157	15	insignificant	insignificant	JJ
cord-350836-1enteev7	157	16	at	at	IN
cord-350836-1enteev7	157	17	around	around	RB
cord-350836-1enteev7	157	18	500	500	CD
cord-350836-1enteev7	157	19	bp	bp	NNP
cord-350836-1enteev7	157	20	(	(	-LRB-
cord-350836-1enteev7	157	21	141	141	CD
cord-350836-1enteev7	157	22	,	,	,
cord-350836-1enteev7	157	23	143	143	CD
cord-350836-1enteev7	157	24	)	)	-RRB-
cord-350836-1enteev7	157	25	.	.	.
cord-350836-1enteev7	158	1	It	-PRON-	PRP
cord-350836-1enteev7	158	2	is	be	VBZ
cord-350836-1enteev7	158	3	significantly	significantly	RB
cord-350836-1enteev7	158	4	shorter	short	JJR
cord-350836-1enteev7	158	5	than	than	IN
cord-350836-1enteev7	158	6	the	the	DT
cord-350836-1enteev7	158	7	length	length	NN
cord-350836-1enteev7	158	8	of	of	IN
cord-350836-1enteev7	158	9	dsRNA	dsrna	NN
cord-350836-1enteev7	158	10	that	that	WDT
cord-350836-1enteev7	158	11	activates	activate	VBZ
cord-350836-1enteev7	158	12	MDA5	MDA5	NNP
cord-350836-1enteev7	158	13	,	,	,
cord-350836-1enteev7	158	14	which	which	WDT
cord-350836-1enteev7	158	15	forms	form	VBZ
cord-350836-1enteev7	158	16	filaments	filament	NNS
cord-350836-1enteev7	158	17	on	on	IN
cord-350836-1enteev7	158	18	2,000	2,000	CD
cord-350836-1enteev7	158	19	bp	bp	NNP
cord-350836-1enteev7	158	20	dsRNA	dsRNA	NNP
cord-350836-1enteev7	158	21	(	(	-LRB-
cord-350836-1enteev7	158	22	137	137	CD
cord-350836-1enteev7	158	23	)	)	-RRB-
cord-350836-1enteev7	158	24	.	.	.
cord-350836-1enteev7	159	1	The	the	DT
cord-350836-1enteev7	159	2	kinetics	kinetic	NNS
cord-350836-1enteev7	159	3	of	of	IN
cord-350836-1enteev7	159	4	RIG	rig	NN
cord-350836-1enteev7	159	5	-	-	:
cord-350836-1enteev7	159	6	I	I	NNP
cord-350836-1enteev7	159	7	and	and	CC
cord-350836-1enteev7	159	8	MDA5	MDA5	NNP
cord-350836-1enteev7	159	9	interacting	interact	VBG
cord-350836-1enteev7	159	10	with	with	IN
cord-350836-1enteev7	159	11	dsRNA	dsRNA	NNS
cord-350836-1enteev7	159	12	(	(	-LRB-
cord-350836-1enteev7	159	13	which	which	WDT
cord-350836-1enteev7	159	14	will	will	MD
cord-350836-1enteev7	159	15	be	be	VB
cord-350836-1enteev7	159	16	discussed	discuss	VBN
cord-350836-1enteev7	159	17	in	in	IN
cord-350836-1enteev7	159	18	detail	detail	NN
cord-350836-1enteev7	159	19	below	below	IN
cord-350836-1enteev7	159	20	)	)	-RRB-
cord-350836-1enteev7	159	21	might	may	MD
cord-350836-1enteev7	159	22	possibly	possibly	RB
cord-350836-1enteev7	159	23	explain	explain	VB
cord-350836-1enteev7	159	24	the	the	DT
cord-350836-1enteev7	159	25	decrease	decrease	NN
cord-350836-1enteev7	159	26	in	in	IN
cord-350836-1enteev7	159	27	dsRNA	dsrna	JJ
cord-350836-1enteev7	159	28	length	length	NN
cord-350836-1enteev7	159	29	efficiency	efficiency	NN
cord-350836-1enteev7	159	30	to	to	TO
cord-350836-1enteev7	159	31	activate	activate	VB
cord-350836-1enteev7	159	32	RIG	rig	NN
cord-350836-1enteev7	159	33	-	-	:
cord-350836-1enteev7	159	34	I	-PRON-	PRP
cord-350836-1enteev7	159	35	as	as	IN
cord-350836-1enteev7	159	36	compared	compare	VBN
cord-350836-1enteev7	159	37	to	to	IN
cord-350836-1enteev7	159	38	MDA5	MDA5	NNP
cord-350836-1enteev7	159	39	,	,	,
cord-350836-1enteev7	159	40	as	as	IN
cord-350836-1enteev7	159	41	RIG	rig	NN
cord-350836-1enteev7	159	42	-	-	:
cord-350836-1enteev7	159	43	I	-PRON-	PRP
cord-350836-1enteev7	159	44	seems	seem	VBZ
cord-350836-1enteev7	159	45	to	to	TO
cord-350836-1enteev7	159	46	first	first	RB
cord-350836-1enteev7	159	47	recognize	recognize	VB
cord-350836-1enteev7	159	48	the	the	DT
cord-350836-1enteev7	159	49	5	5	CD
cord-350836-1enteev7	159	50	′	′	CD
cord-350836-1enteev7	159	51	ppp	ppp	NN
cord-350836-1enteev7	159	52	end	end	NN
cord-350836-1enteev7	159	53	before	before	IN
cord-350836-1enteev7	159	54	sliding	slide	VBG
cord-350836-1enteev7	159	55	down	down	IN
cord-350836-1enteev7	159	56	the	the	DT
cord-350836-1enteev7	159	57	length	length	NN
cord-350836-1enteev7	159	58	of	of	IN
cord-350836-1enteev7	159	59	the	the	DT
cord-350836-1enteev7	159	60	dsRNA	dsrna	NN
cord-350836-1enteev7	159	61	(	(	-LRB-
cord-350836-1enteev7	159	62	144	144	CD
cord-350836-1enteev7	159	63	)	)	-RRB-
cord-350836-1enteev7	159	64	,	,	,
cord-350836-1enteev7	159	65	whereas	whereas	IN
cord-350836-1enteev7	159	66	MDA5	MDA5	NNP
cord-350836-1enteev7	159	67	dynamically	dynamically	RB
cord-350836-1enteev7	159	68	associates	associate	NNS
cord-350836-1enteev7	159	69	and	and	CC
cord-350836-1enteev7	159	70	disassociates	disassociate	VBZ
cord-350836-1enteev7	159	71	along	along	IN
cord-350836-1enteev7	159	72	the	the	DT
cord-350836-1enteev7	159	73	length	length	NN
cord-350836-1enteev7	159	74	of	of	IN
cord-350836-1enteev7	159	75	long	long	JJ
cord-350836-1enteev7	159	76	dsRNA	dsrna	NN
cord-350836-1enteev7	159	77	(	(	-LRB-
cord-350836-1enteev7	159	78	137	137	CD
cord-350836-1enteev7	159	79	)	)	-RRB-
cord-350836-1enteev7	159	80	.	.	.
cord-350836-1enteev7	160	1	Meanwhile	meanwhile	RB
cord-350836-1enteev7	160	2	,	,	,
cord-350836-1enteev7	160	3	it	-PRON-	PRP
cord-350836-1enteev7	160	4	is	be	VBZ
cord-350836-1enteev7	160	5	still	still	RB
cord-350836-1enteev7	160	6	unclear	unclear	JJ
cord-350836-1enteev7	160	7	whether	whether	IN
cord-350836-1enteev7	160	8	RIG	rig	NN
cord-350836-1enteev7	160	9	-	-	:
cord-350836-1enteev7	160	10	I	-PRON-	PRP
cord-350836-1enteev7	160	11	can	can	MD
cord-350836-1enteev7	160	12	preferentially	preferentially	RB
cord-350836-1enteev7	160	13	be	be	VB
cord-350836-1enteev7	160	14	activated	activate	VBN
cord-350836-1enteev7	160	15	by	by	IN
cord-350836-1enteev7	160	16	longer	long	JJR
cord-350836-1enteev7	160	17	dsRNA	dsrna	NN
cord-350836-1enteev7	161	1	independently	independently	RB
cord-350836-1enteev7	161	2	of	of	IN
cord-350836-1enteev7	161	3	its	-PRON-	PRP$
cord-350836-1enteev7	161	4	unknown	unknown	JJ
cord-350836-1enteev7	161	5	ability	ability	NN
cord-350836-1enteev7	161	6	to	to	TO
cord-350836-1enteev7	161	7	form	form	VB
cord-350836-1enteev7	161	8	filaments	filament	NNS
cord-350836-1enteev7	161	9	in	in	IN
cord-350836-1enteev7	161	10	-	-	HYPH
cord-350836-1enteev7	161	11	vitro	vitro	FW
cord-350836-1enteev7	161	12	(	(	-LRB-
cord-350836-1enteev7	161	13	145	145	CD
cord-350836-1enteev7	161	14	)	)	-RRB-
cord-350836-1enteev7	161	15	.	.	.
cord-350836-1enteev7	162	1	Once	once	RB
cord-350836-1enteev7	162	2	fully	fully	RB
cord-350836-1enteev7	162	3	activated	activate	VBN
cord-350836-1enteev7	162	4	and	and	CC
cord-350836-1enteev7	162	5	oligomerized	oligomerize	VBN
cord-350836-1enteev7	162	6	,	,	,
cord-350836-1enteev7	162	7	the	the	DT
cord-350836-1enteev7	162	8	RIG	rig	NN
cord-350836-1enteev7	162	9	-	-	HYPH
cord-350836-1enteev7	162	10	I	-PRON-	PRP
cord-350836-1enteev7	162	11	CARD	card	NN
cord-350836-1enteev7	162	12	domain	domain	NN
cord-350836-1enteev7	162	13	can	can	MD
cord-350836-1enteev7	162	14	then	then	RB
cord-350836-1enteev7	162	15	interact	interact	VB
cord-350836-1enteev7	162	16	with	with	IN
cord-350836-1enteev7	162	17	MAVS	MAVS	NNPS
cord-350836-1enteev7	162	18	(	(	-LRB-
cord-350836-1enteev7	162	19	146	146	CD
cord-350836-1enteev7	162	20	)	)	-RRB-
cord-350836-1enteev7	162	21	(	(	-LRB-
cord-350836-1enteev7	162	22	147	147	CD
cord-350836-1enteev7	162	23	)	)	-RRB-
cord-350836-1enteev7	162	24	(	(	-LRB-
cord-350836-1enteev7	162	25	148	148	CD
cord-350836-1enteev7	162	26	)	)	-RRB-
cord-350836-1enteev7	163	1	(	(	-LRB-
cord-350836-1enteev7	163	2	149	149	CD
cord-350836-1enteev7	163	3	)	)	-RRB-
cord-350836-1enteev7	164	1	(	(	-LRB-
cord-350836-1enteev7	164	2	Figures	figure	NNS
cord-350836-1enteev7	164	3	4E	4e	JJ
cord-350836-1enteev7	164	4	,	,	,
cord-350836-1enteev7	164	5	I	-PRON-	PRP
cord-350836-1enteev7	164	6	)	)	-RRB-
cord-350836-1enteev7	164	7	,	,	,
cord-350836-1enteev7	164	8	which	which	WDT
cord-350836-1enteev7	164	9	is	be	VBZ
cord-350836-1enteev7	164	10	part	part	NN
cord-350836-1enteev7	164	11	of	of	IN
cord-350836-1enteev7	164	12	a	a	DT
cord-350836-1enteev7	164	13	protein	protein	NN
cord-350836-1enteev7	164	14	complex	complex	NN
cord-350836-1enteev7	164	15	containing	contain	VBG
cord-350836-1enteev7	164	16	a	a	DT
cord-350836-1enteev7	164	17	variety	variety	NN
cord-350836-1enteev7	164	18	of	of	IN
cord-350836-1enteev7	164	19	other	other	JJ
cord-350836-1enteev7	164	20	cellular	cellular	JJ
cord-350836-1enteev7	164	21	proteins	protein	NNS
cord-350836-1enteev7	164	22	(	(	-LRB-
cord-350836-1enteev7	164	23	6	6	CD
cord-350836-1enteev7	164	24	)	)	-RRB-
cord-350836-1enteev7	164	25	(	(	-LRB-
cord-350836-1enteev7	164	26	7	7	LS
cord-350836-1enteev7	164	27	)	)	-RRB-
cord-350836-1enteev7	164	28	(	(	-LRB-
cord-350836-1enteev7	164	29	8)	8)	NNP
cord-350836-1enteev7	164	30	(	(	-LRB-
cord-350836-1enteev7	164	31	9	9	CD
cord-350836-1enteev7	164	32	)	)	-RRB-
cord-350836-1enteev7	164	33	.	.	.
cord-350836-1enteev7	165	1	While	while	IN
cord-350836-1enteev7	165	2	the	the	DT
cord-350836-1enteev7	165	3	MDA5	MDA5	NNP
cord-350836-1enteev7	165	4	CARD	card	NN
cord-350836-1enteev7	165	5	domain	domain	NN
cord-350836-1enteev7	165	6	has	have	VBZ
cord-350836-1enteev7	165	7	much	much	RB
cord-350836-1enteev7	165	8	weaker	weak	JJR
cord-350836-1enteev7	165	9	direct	direct	JJ
cord-350836-1enteev7	165	10	association	association	NN
cord-350836-1enteev7	165	11	with	with	IN
cord-350836-1enteev7	165	12	MAVS	MAVS	NNPS
cord-350836-1enteev7	165	13	than	than	IN
cord-350836-1enteev7	165	14	the	the	DT
cord-350836-1enteev7	165	15	RIG	rig	NN
cord-350836-1enteev7	165	16	-	-	HYPH
cord-350836-1enteev7	165	17	I	-PRON-	PRP
cord-350836-1enteev7	165	18	CARD	card	NN
cord-350836-1enteev7	165	19	domain	domain	NN
cord-350836-1enteev7	165	20	,	,	,
cord-350836-1enteev7	165	21	it	-PRON-	PRP
cord-350836-1enteev7	165	22	is	be	VBZ
cord-350836-1enteev7	165	23	sufficient	sufficient	JJ
cord-350836-1enteev7	165	24	to	to	TO
cord-350836-1enteev7	165	25	lead	lead	VB
cord-350836-1enteev7	165	26	to	to	IN
cord-350836-1enteev7	165	27	its	-PRON-	PRP$
cord-350836-1enteev7	165	28	activation	activation	NN
cord-350836-1enteev7	165	29	and	and	CC
cord-350836-1enteev7	165	30	potentiates	potentiate	VBZ
cord-350836-1enteev7	165	31	activation	activation	NN
cord-350836-1enteev7	165	32	of	of	IN
cord-350836-1enteev7	165	33	MAVS	MAVS	NNPS
cord-350836-1enteev7	165	34	by	by	IN
cord-350836-1enteev7	165	35	RIG	rig	NN
cord-350836-1enteev7	165	36	-	-	:
cord-350836-1enteev7	165	37	I	i	NN
cord-350836-1enteev7	165	38	(	(	-LRB-
cord-350836-1enteev7	165	39	146	146	CD
cord-350836-1enteev7	165	40	)	)	-RRB-
cord-350836-1enteev7	165	41	,	,	,
cord-350836-1enteev7	165	42	the	the	DT
cord-350836-1enteev7	165	43	mechanisms	mechanism	NNS
cord-350836-1enteev7	165	44	of	of	IN
cord-350836-1enteev7	165	45	which	which	WDT
cord-350836-1enteev7	165	46	have	have	VBP
cord-350836-1enteev7	165	47	yet	yet	RB
cord-350836-1enteev7	165	48	to	to	TO
cord-350836-1enteev7	165	49	be	be	VB
cord-350836-1enteev7	165	50	determined	determine	VBN
cord-350836-1enteev7	165	51	.	.	.
cord-350836-1enteev7	166	1	The	the	DT
cord-350836-1enteev7	166	2	activated	activate	VBN
cord-350836-1enteev7	166	3	MAVS	MAVS	NNP
cord-350836-1enteev7	166	4	complex	complex	JJ
cord-350836-1enteev7	166	5	then	then	RB
cord-350836-1enteev7	166	6	initiates	initiate	VBZ
cord-350836-1enteev7	166	7	a	a	DT
cord-350836-1enteev7	166	8	molecular	molecular	JJ
cord-350836-1enteev7	166	9	cascade	cascade	NN
cord-350836-1enteev7	166	10	which	which	WDT
cord-350836-1enteev7	166	11	eventually	eventually	RB
cord-350836-1enteev7	166	12	results	result	VBZ
cord-350836-1enteev7	166	13	in	in	IN
cord-350836-1enteev7	166	14	expression	expression	NN
cord-350836-1enteev7	166	15	of	of	IN
cord-350836-1enteev7	166	16	IFN1	IFN1	NNP
cord-350836-1enteev7	166	17	(	(	-LRB-
cord-350836-1enteev7	166	18	150	150	CD
cord-350836-1enteev7	166	19	)	)	-RRB-
cord-350836-1enteev7	167	1	(	(	-LRB-
cord-350836-1enteev7	167	2	Figure	figure	NN
cord-350836-1enteev7	167	3	2	2	CD
cord-350836-1enteev7	167	4	)	)	-RRB-
cord-350836-1enteev7	167	5	.	.	.
cord-350836-1enteev7	168	1	Interestingly	interestingly	RB
cord-350836-1enteev7	168	2	,	,	,
cord-350836-1enteev7	168	3	full	full	JJ
cord-350836-1enteev7	168	4	length	length	NN
cord-350836-1enteev7	168	5	RIG	rig	NN
cord-350836-1enteev7	168	6	-	-	:
cord-350836-1enteev7	168	7	I	I	NNP
cord-350836-1enteev7	168	8	,	,	,
cord-350836-1enteev7	168	9	when	when	WRB
cord-350836-1enteev7	168	10	overexpressed	overexpresse	VBN
cord-350836-1enteev7	168	11	,	,	,
cord-350836-1enteev7	168	12	has	have	VBZ
cord-350836-1enteev7	168	13	been	be	VBN
cord-350836-1enteev7	168	14	found	find	VBN
cord-350836-1enteev7	168	15	to	to	TO
cord-350836-1enteev7	168	16	associate	associate	VB
cord-350836-1enteev7	168	17	with	with	IN
cord-350836-1enteev7	168	18	MAVS	MAVS	NNPS
cord-350836-1enteev7	168	19	in	in	IN
cord-350836-1enteev7	168	20	the	the	DT
cord-350836-1enteev7	168	21	absence	absence	NN
cord-350836-1enteev7	168	22	of	of	IN
cord-350836-1enteev7	168	23	activating	activate	VBG
cord-350836-1enteev7	168	24	dsRNA	dsrna	NN
cord-350836-1enteev7	168	25	and	and	CC
cord-350836-1enteev7	168	26	the	the	DT
cord-350836-1enteev7	168	27	interaction	interaction	NN
cord-350836-1enteev7	168	28	can	can	MD
cord-350836-1enteev7	168	29	be	be	VB
cord-350836-1enteev7	168	30	ablated	ablate	VBN
cord-350836-1enteev7	168	31	by	by	IN
cord-350836-1enteev7	168	32	phosphorylation	phosphorylation	NN
cord-350836-1enteev7	168	33	at	at	IN
cord-350836-1enteev7	168	34	S8	S8	NNP
cord-350836-1enteev7	168	35	and	and	CC
cord-350836-1enteev7	168	36	T170	T170	NNP
cord-350836-1enteev7	168	37	(	(	-LRB-
cord-350836-1enteev7	168	38	87	87	CD
cord-350836-1enteev7	168	39	)	)	-RRB-
cord-350836-1enteev7	168	40	,	,	,
cord-350836-1enteev7	168	41	suggesting	suggest	VBG
cord-350836-1enteev7	168	42	that	that	IN
cord-350836-1enteev7	168	43	the	the	DT
cord-350836-1enteev7	168	44	CARD	card	NN
cord-350836-1enteev7	168	45	phosphorylation	phosphorylation	NN
cord-350836-1enteev7	168	46	sites	site	NNS
cord-350836-1enteev7	168	47	function	function	VBP
cord-350836-1enteev7	168	48	at	at	IN
cord-350836-1enteev7	168	49	least	least	JJS
cord-350836-1enteev7	168	50	in	in	IN
cord-350836-1enteev7	168	51	part	part	NN
cord-350836-1enteev7	168	52	to	to	TO
cord-350836-1enteev7	168	53	prevent	prevent	VB
cord-350836-1enteev7	168	54	association	association	NN
cord-350836-1enteev7	168	55	of	of	IN
cord-350836-1enteev7	168	56	the	the	DT
cord-350836-1enteev7	168	57	inactive	inactive	JJ
cord-350836-1enteev7	168	58	form	form	NN
cord-350836-1enteev7	168	59	of	of	IN
cord-350836-1enteev7	168	60	RIG	rig	NN
cord-350836-1enteev7	168	61	-	-	:
cord-350836-1enteev7	168	62	I	-PRON-	PRP
cord-350836-1enteev7	168	63	with	with	IN
cord-350836-1enteev7	168	64	MAVS	MAVS	NNPS
cord-350836-1enteev7	168	65	.	.	.
cord-350836-1enteev7	169	1	Furthermore	furthermore	RB
cord-350836-1enteev7	169	2	,	,	,
cord-350836-1enteev7	169	3	the	the	DT
cord-350836-1enteev7	169	4	crystal	crystal	NN
cord-350836-1enteev7	169	5	structure	structure	NN
cord-350836-1enteev7	169	6	of	of	IN
cord-350836-1enteev7	169	7	the	the	DT
cord-350836-1enteev7	169	8	interaction	interaction	NN
cord-350836-1enteev7	169	9	between	between	IN
cord-350836-1enteev7	169	10	the	the	DT
cord-350836-1enteev7	169	11	RIG	rig	NN
cord-350836-1enteev7	169	12	-	-	HYPH
cord-350836-1enteev7	169	13	I	-PRON-	PRP
cord-350836-1enteev7	169	14	CARD	card	VBP
cord-350836-1enteev7	169	15	and	and	CC
cord-350836-1enteev7	169	16	MAVS	MAVS	NNP
cord-350836-1enteev7	169	17	CARD	card	NN
cord-350836-1enteev7	169	18	domains	domain	NNS
cord-350836-1enteev7	169	19	shows	show	VBZ
cord-350836-1enteev7	169	20	the	the	DT
cord-350836-1enteev7	169	21	RIG-	RIG-	NNP
cord-350836-1enteev7	170	1	I	-PRON-	PRP
cord-350836-1enteev7	170	2	CARD2	card2	VBP
cord-350836-1enteev7	170	3	domain	domain	NN
cord-350836-1enteev7	170	4	interacting	interact	VBG
cord-350836-1enteev7	170	5	with	with	IN
cord-350836-1enteev7	170	6	MAVS	MAVS	NNP
cord-350836-1enteev7	170	7	CARD	card	NN
cord-350836-1enteev7	170	8	domains	domain	NNS
cord-350836-1enteev7	170	9	on	on	IN
cord-350836-1enteev7	170	10	the	the	DT
cord-350836-1enteev7	170	11	outside	outside	NN
cord-350836-1enteev7	170	12	of	of	IN
cord-350836-1enteev7	170	13	the	the	DT
cord-350836-1enteev7	170	14	tetramer	tetramer	NN
cord-350836-1enteev7	170	15	and	and	CC
cord-350836-1enteev7	170	16	the	the	DT
cord-350836-1enteev7	170	17	RIG-	RIG-	NNP
cord-350836-1enteev7	171	1	I	-PRON-	PRP
cord-350836-1enteev7	172	1	CARD1	card1	RB
cord-350836-1enteev7	173	1	(	(	-LRB-
cord-350836-1enteev7	173	2	1	1	CD
cord-350836-1enteev7	173	3	-	-	SYM
cord-350836-1enteev7	173	4	87	87	CD
cord-350836-1enteev7	173	5	)	)	-RRB-
cord-350836-1enteev7	173	6	domain	domain	NN
cord-350836-1enteev7	173	7	facing	face	VBG
cord-350836-1enteev7	173	8	toward	toward	IN
cord-350836-1enteev7	173	9	the	the	DT
cord-350836-1enteev7	173	10	center	center	NN
cord-350836-1enteev7	173	11	of	of	IN
cord-350836-1enteev7	173	12	the	the	DT
cord-350836-1enteev7	173	13	tetramer	tetramer	NN
cord-350836-1enteev7	173	14	(	(	-LRB-
cord-350836-1enteev7	173	15	63	63	CD
cord-350836-1enteev7	173	16	)	)	-RRB-
cord-350836-1enteev7	173	17	(	(	-LRB-
cord-350836-1enteev7	173	18	Figure	Figure	NNP
cord-350836-1enteev7	173	19	3E	3e	NN
cord-350836-1enteev7	173	20	)	)	-RRB-
cord-350836-1enteev7	173	21	.	.	.
cord-350836-1enteev7	174	1	NMR	NMR	NNP
cord-350836-1enteev7	174	2	solution	solution	NN
cord-350836-1enteev7	174	3	structures	structure	NNS
cord-350836-1enteev7	174	4	of	of	IN
cord-350836-1enteev7	174	5	RIG-	rig-	NN
cord-350836-1enteev7	175	1	I	-PRON-	PRP
cord-350836-1enteev7	175	2	CARD2	card2	VBP
cord-350836-1enteev7	175	3	also	also	RB
cord-350836-1enteev7	175	4	shows	show	VBZ
cord-350836-1enteev7	175	5	that	that	IN
cord-350836-1enteev7	175	6	T170	t170	NN
cord-350836-1enteev7	175	7	(	(	-LRB-
cord-350836-1enteev7	175	8	which	which	WDT
cord-350836-1enteev7	175	9	is	be	VBZ
cord-350836-1enteev7	175	10	required	require	VBN
cord-350836-1enteev7	175	11	for	for	IN
cord-350836-1enteev7	175	12	dephosphorylation	dephosphorylation	NN
cord-350836-1enteev7	175	13	by	by	IN
cord-350836-1enteev7	175	14	PP1-α	PP1-α	NNP
cord-350836-1enteev7	175	15	/	/	SYM
cord-350836-1enteev7	175	16	γ	γ	NNP
cord-350836-1enteev7	175	17	)	)	-RRB-
cord-350836-1enteev7	175	18	is	be	VBZ
cord-350836-1enteev7	175	19	largely	largely	RB
cord-350836-1enteev7	175	20	buried	bury	VBN
cord-350836-1enteev7	175	21	within	within	IN
cord-350836-1enteev7	175	22	the	the	DT
cord-350836-1enteev7	175	23	CARD2	CARD2	NNP
cord-350836-1enteev7	175	24	domain	domain	NN
cord-350836-1enteev7	175	25	in	in	IN
cord-350836-1enteev7	175	26	a	a	DT
cord-350836-1enteev7	175	27	section	section	NN
cord-350836-1enteev7	175	28	that	that	WDT
cord-350836-1enteev7	175	29	would	would	MD
cord-350836-1enteev7	175	30	be	be	VB
cord-350836-1enteev7	175	31	in	in	IN
cord-350836-1enteev7	175	32	closer	close	JJR
cord-350836-1enteev7	175	33	contact	contact	NN
cord-350836-1enteev7	175	34	with	with	IN
cord-350836-1enteev7	175	35	the	the	DT
cord-350836-1enteev7	175	36	helicase	helicase	NN
cord-350836-1enteev7	175	37	domains	domain	NNS
cord-350836-1enteev7	175	38	,	,	,
cord-350836-1enteev7	175	39	suggesting	suggest	VBG
cord-350836-1enteev7	175	40	that	that	IN
cord-350836-1enteev7	175	41	dephosphorylation	dephosphorylation	NN
cord-350836-1enteev7	175	42	of	of	IN
cord-350836-1enteev7	175	43	T170	t170	CD
cord-350836-1enteev7	175	44	affects	affect	VBZ
cord-350836-1enteev7	175	45	an	an	DT
cord-350836-1enteev7	175	46	interaction	interaction	NN
cord-350836-1enteev7	175	47	domain	domain	NN
cord-350836-1enteev7	175	48	between	between	IN
cord-350836-1enteev7	175	49	CARD2	CARD2	NNS
cord-350836-1enteev7	175	50	and	and	CC
cord-350836-1enteev7	175	51	the	the	DT
cord-350836-1enteev7	175	52	C	C	NNP
cord-350836-1enteev7	175	53	terminus	terminus	NN
cord-350836-1enteev7	175	54	(	(	-LRB-
cord-350836-1enteev7	175	55	151	151	CD
cord-350836-1enteev7	175	56	)	)	-RRB-
cord-350836-1enteev7	175	57	.	.	.
cord-350836-1enteev7	176	1	Furthermore	furthermore	RB
cord-350836-1enteev7	176	2	,	,	,
cord-350836-1enteev7	176	3	NMR	NMR	NNP
cord-350836-1enteev7	176	4	of	of	IN
cord-350836-1enteev7	176	5	a	a	DT
cord-350836-1enteev7	176	6	C	c	NN
cord-350836-1enteev7	176	7	terminal	terminal	NN
cord-350836-1enteev7	176	8	construct	construct	NN
cord-350836-1enteev7	176	9	of	of	IN
cord-350836-1enteev7	176	10	RIG	rig	NN
cord-350836-1enteev7	176	11	-	-	:
cord-350836-1enteev7	176	12	I	-PRON-	PRP
cord-350836-1enteev7	176	13	with	with	IN
cord-350836-1enteev7	176	14	the	the	DT
cord-350836-1enteev7	176	15	CARD2	CARD2	NNP
cord-350836-1enteev7	176	16	domain	domain	NN
cord-350836-1enteev7	176	17	shows	show	VBZ
cord-350836-1enteev7	176	18	stable	stable	JJ
cord-350836-1enteev7	176	19	interactions	interaction	NNS
cord-350836-1enteev7	176	20	of	of	IN
cord-350836-1enteev7	176	21	CARD2	CARD2	NNS
cord-350836-1enteev7	176	22	and	and	CC
cord-350836-1enteev7	176	23	the	the	DT
cord-350836-1enteev7	176	24	C	C	NNP
cord-350836-1enteev7	176	25	terminal	terminal	NN
cord-350836-1enteev7	176	26	domain	domain	NN
cord-350836-1enteev7	176	27	(	(	-LRB-
cord-350836-1enteev7	176	28	151	151	CD
cord-350836-1enteev7	176	29	)	)	-RRB-
cord-350836-1enteev7	176	30	.	.	.
cord-350836-1enteev7	177	1	What	what	WP
cord-350836-1enteev7	177	2	all	all	PDT
cord-350836-1enteev7	177	3	this	this	DT
cord-350836-1enteev7	177	4	may	may	MD
cord-350836-1enteev7	177	5	mean	mean	VB
cord-350836-1enteev7	177	6	is	be	VBZ
cord-350836-1enteev7	177	7	that	that	IN
cord-350836-1enteev7	177	8	,	,	,
cord-350836-1enteev7	177	9	while	while	IN
cord-350836-1enteev7	177	10	the	the	DT
cord-350836-1enteev7	177	11	CARD1	card1	NN
cord-350836-1enteev7	177	12	domain	domain	NN
cord-350836-1enteev7	177	13	of	of	IN
cord-350836-1enteev7	177	14	RIG	rig	NN
cord-350836-1enteev7	177	15	-	-	:
cord-350836-1enteev7	177	16	I	-PRON-	PRP
cord-350836-1enteev7	177	17	is	be	VBZ
cord-350836-1enteev7	177	18	somewhat	somewhat	RB
cord-350836-1enteev7	177	19	exposed	expose	VBN
cord-350836-1enteev7	177	20	in	in	IN
cord-350836-1enteev7	177	21	its	-PRON-	PRP$
cord-350836-1enteev7	177	22	inactivated	inactivate	VBN
cord-350836-1enteev7	177	23	form	form	NN
cord-350836-1enteev7	177	24	and	and	CC
cord-350836-1enteev7	177	25	therefore	therefore	RB
cord-350836-1enteev7	177	26	can	can	MD
cord-350836-1enteev7	177	27	be	be	VB
cord-350836-1enteev7	177	28	shown	show	VBN
cord-350836-1enteev7	177	29	to	to	TO
cord-350836-1enteev7	177	30	interact	interact	VB
cord-350836-1enteev7	177	31	with	with	IN
cord-350836-1enteev7	177	32	MAVS	MAVS	NNPS
cord-350836-1enteev7	177	33	,	,	,
cord-350836-1enteev7	177	34	full	full	JJ
cord-350836-1enteev7	177	35	exposure	exposure	NN
cord-350836-1enteev7	177	36	and	and	CC
cord-350836-1enteev7	177	37	engagement	engagement	NN
cord-350836-1enteev7	177	38	of	of	IN
cord-350836-1enteev7	177	39	both	both	DT
cord-350836-1enteev7	177	40	RIG	rig	NN
cord-350836-1enteev7	177	41	-	-	HYPH
cord-350836-1enteev7	177	42	I	i	NN
cord-350836-1enteev7	177	43	CARD	card	NN
cord-350836-1enteev7	177	44	domains	domain	NNS
cord-350836-1enteev7	177	45	(	(	-LRB-
cord-350836-1enteev7	177	46	CARD1	card1	NN
cord-350836-1enteev7	177	47	and	and	CC
cord-350836-1enteev7	177	48	CARD2	CARD2	NNPS
cord-350836-1enteev7	177	49	)	)	-RRB-
cord-350836-1enteev7	177	50	with	with	IN
cord-350836-1enteev7	177	51	the	the	DT
cord-350836-1enteev7	177	52	CARD	card	NN
cord-350836-1enteev7	177	53	domain	domain	NN
cord-350836-1enteev7	177	54	of	of	IN
cord-350836-1enteev7	177	55	MAVS	MAVS	NNPS
cord-350836-1enteev7	177	56	is	be	VBZ
cord-350836-1enteev7	177	57	necessary	necessary	JJ
cord-350836-1enteev7	177	58	in	in	IN
cord-350836-1enteev7	177	59	order	order	NN
cord-350836-1enteev7	177	60	to	to	TO
cord-350836-1enteev7	177	61	induce	induce	VB
cord-350836-1enteev7	177	62	IFN1	IFN1	NNP
cord-350836-1enteev7	177	63	signaling	signaling	NN
cord-350836-1enteev7	177	64	.	.	.
cord-350836-1enteev7	178	1	The	the	DT
cord-350836-1enteev7	178	2	CARD	card	NN
cord-350836-1enteev7	178	3	domains	domain	NNS
cord-350836-1enteev7	178	4	of	of	IN
cord-350836-1enteev7	178	5	RIG	rig	NN
cord-350836-1enteev7	178	6	-	-	:
cord-350836-1enteev7	178	7	I	-PRON-	PRP
cord-350836-1enteev7	178	8	also	also	RB
cord-350836-1enteev7	178	9	appear	appear	VBP
cord-350836-1enteev7	178	10	to	to	TO
cord-350836-1enteev7	178	11	be	be	VB
cord-350836-1enteev7	178	12	generally	generally	RB
cord-350836-1enteev7	178	13	structurally	structurally	RB
cord-350836-1enteev7	178	14	stable	stable	JJ
cord-350836-1enteev7	178	15	,	,	,
cord-350836-1enteev7	178	16	as	as	IN
cord-350836-1enteev7	178	17	electron	electron	NN
cord-350836-1enteev7	178	18	microscopic	microscopic	JJ
cord-350836-1enteev7	178	19	structures	structure	NNS
cord-350836-1enteev7	178	20	have	have	VBP
cord-350836-1enteev7	178	21	been	be	VBN
cord-350836-1enteev7	178	22	obtained	obtain	VBN
cord-350836-1enteev7	178	23	of	of	IN
cord-350836-1enteev7	178	24	the	the	DT
cord-350836-1enteev7	178	25	full	full	JJ
cord-350836-1enteev7	178	26	length	length	NN
cord-350836-1enteev7	178	27	RIG	rig	NN
cord-350836-1enteev7	178	28	-	-	:
cord-350836-1enteev7	178	29	I	-PRON-	PRP
cord-350836-1enteev7	178	30	bound	bind	VBN
cord-350836-1enteev7	178	31	to	to	TO
cord-350836-1enteev7	178	32	blunt	blunt	VB
cord-350836-1enteev7	178	33	-	-	HYPH
cord-350836-1enteev7	178	34	ended	ended	JJ
cord-350836-1enteev7	178	35	dsRNA	dsrna	NN
cord-350836-1enteev7	178	36	showing	show	VBG
cord-350836-1enteev7	178	37	both	both	CC
cord-350836-1enteev7	178	38	CARD	card	NN
cord-350836-1enteev7	178	39	domains	domain	NNS
cord-350836-1enteev7	178	40	exposed	expose	VBN
cord-350836-1enteev7	178	41	(	(	-LRB-
cord-350836-1enteev7	178	42	87	87	CD
cord-350836-1enteev7	178	43	)	)	-RRB-
cord-350836-1enteev7	178	44	.	.	.
cord-350836-1enteev7	179	1	On	on	IN
cord-350836-1enteev7	179	2	the	the	DT
cord-350836-1enteev7	179	3	contrary	contrary	NN
cord-350836-1enteev7	179	4	,	,	,
cord-350836-1enteev7	179	5	the	the	DT
cord-350836-1enteev7	179	6	CARD	card	NN
cord-350836-1enteev7	179	7	domains	domain	NNS
cord-350836-1enteev7	179	8	of	of	IN
cord-350836-1enteev7	179	9	MDA5	MDA5	NNP
cord-350836-1enteev7	179	10	may	may	MD
cord-350836-1enteev7	179	11	be	be	VB
cord-350836-1enteev7	179	12	comparatively	comparatively	RB
cord-350836-1enteev7	179	13	more	more	RBR
cord-350836-1enteev7	179	14	flexible	flexible	JJ
cord-350836-1enteev7	179	15	than	than	IN
cord-350836-1enteev7	179	16	those	those	DT
cord-350836-1enteev7	179	17	of	of	IN
cord-350836-1enteev7	179	18	RIG	rig	NN
cord-350836-1enteev7	179	19	-	-	:
cord-350836-1enteev7	179	20	I	-PRON-	PRP
cord-350836-1enteev7	179	21	in	in	IN
cord-350836-1enteev7	179	22	order	order	NN
cord-350836-1enteev7	179	23	to	to	TO
cord-350836-1enteev7	179	24	mediate	mediate	VB
cord-350836-1enteev7	179	25	long	long	JJ
cord-350836-1enteev7	179	26	MDA5-dsRNA	MDA5-dsRNA	NNP
cord-350836-1enteev7	179	27	filament	filament	NN
cord-350836-1enteev7	179	28	formation	formation	NN
cord-350836-1enteev7	179	29	(	(	-LRB-
cord-350836-1enteev7	179	30	99	99	CD
cord-350836-1enteev7	179	31	)	)	-RRB-
cord-350836-1enteev7	179	32	.	.	.
cord-350836-1enteev7	180	1	The	the	DT
cord-350836-1enteev7	180	2	activated	activate	VBN
cord-350836-1enteev7	180	3	MAVS	MAVS	NNP
cord-350836-1enteev7	180	4	complex	complex	NNP
cord-350836-1enteev7	180	5	induces	induce	VBZ
cord-350836-1enteev7	180	6	association	association	NN
cord-350836-1enteev7	180	7	of	of	IN
cord-350836-1enteev7	180	8	the	the	DT
cord-350836-1enteev7	180	9	inhibitor	inhibitor	NN
cord-350836-1enteev7	180	10	of	of	IN
cord-350836-1enteev7	180	11	nuclear	nuclear	JJ
cord-350836-1enteev7	180	12	factor	factor	NN
cord-350836-1enteev7	180	13	kappa	kappa	NN
cord-350836-1enteev7	180	14	-	-	HYPH
cord-350836-1enteev7	180	15	B	B	NNP
cord-350836-1enteev7	180	16	kinase	kinase	NN
cord-350836-1enteev7	180	17	subunit	subunit	NN
cord-350836-1enteev7	180	18	epsilon	epsilon	NN
cord-350836-1enteev7	180	19	(	(	-LRB-
cord-350836-1enteev7	180	20	IKKε	IKKε	NNP
cord-350836-1enteev7	180	21	)	)	-RRB-
cord-350836-1enteev7	180	22	and	and	CC
cord-350836-1enteev7	180	23	the	the	DT
cord-350836-1enteev7	180	24	serine	serine	NN
cord-350836-1enteev7	180	25	/	/	SYM
cord-350836-1enteev7	180	26	threonine	threonine	NN
cord-350836-1enteev7	180	27	-	-	HYPH
cord-350836-1enteev7	180	28	protein	protein	NN
cord-350836-1enteev7	180	29	kinase	kinase	NN
cord-350836-1enteev7	180	30	1	1	CD
cord-350836-1enteev7	180	31	(	(	-LRB-
cord-350836-1enteev7	180	32	TBK1	TBK1	NNP
cord-350836-1enteev7	180	33	)	)	-RRB-
cord-350836-1enteev7	181	1	(	(	-LRB-
cord-350836-1enteev7	181	2	10	10	CD
cord-350836-1enteev7	181	3	-	-	SYM
cord-350836-1enteev7	181	4	12	12	CD
cord-350836-1enteev7	181	5	)	)	-RRB-
cord-350836-1enteev7	181	6	,	,	,
cord-350836-1enteev7	181	7	which	which	WDT
cord-350836-1enteev7	181	8	collectively	collectively	RB
cord-350836-1enteev7	181	9	phosphorylate	phosphorylate	VBP
cord-350836-1enteev7	181	10	the	the	DT
cord-350836-1enteev7	181	11	interferon	interferon	NN
cord-350836-1enteev7	181	12	regulatory	regulatory	JJ
cord-350836-1enteev7	181	13	factors	factor	NNS
cord-350836-1enteev7	181	14	3	3	CD
cord-350836-1enteev7	181	15	and	and	CC
cord-350836-1enteev7	181	16	7	7	CD
cord-350836-1enteev7	181	17	(	(	-LRB-
cord-350836-1enteev7	181	18	IRF3	IRF3	NNP
cord-350836-1enteev7	181	19	and	and	CC
cord-350836-1enteev7	181	20	IRF7	IRF7	NNP
cord-350836-1enteev7	181	21	)	)	-RRB-
cord-350836-1enteev7	182	1	(	(	-LRB-
cord-350836-1enteev7	182	2	13	13	CD
cord-350836-1enteev7	182	3	)	)	-RRB-
cord-350836-1enteev7	183	1	(	(	-LRB-
cord-350836-1enteev7	183	2	Figure	figure	NN
cord-350836-1enteev7	183	3	1	1	CD
cord-350836-1enteev7	183	4	)	)	-RRB-
cord-350836-1enteev7	183	5	.	.	.
cord-350836-1enteev7	184	1	IKKε	IKKε	NNPS
cord-350836-1enteev7	184	2	and	and	CC
cord-350836-1enteev7	184	3	TBK1	TBK1	NNP
cord-350836-1enteev7	184	4	also	also	RB
cord-350836-1enteev7	184	5	interact	interact	VBP
cord-350836-1enteev7	184	6	with	with	IN
cord-350836-1enteev7	184	7	a	a	DT
cord-350836-1enteev7	184	8	number	number	NN
cord-350836-1enteev7	184	9	of	of	IN
cord-350836-1enteev7	184	10	other	other	JJ
cord-350836-1enteev7	184	11	co	co	NNS
cord-350836-1enteev7	184	12	-	-	NNS
cord-350836-1enteev7	184	13	factors	factor	NNS
cord-350836-1enteev7	184	14	(	(	-LRB-
cord-350836-1enteev7	184	15	152	152	CD
cord-350836-1enteev7	184	16	,	,	,
cord-350836-1enteev7	184	17	153	153	CD
cord-350836-1enteev7	184	18	)	)	-RRB-
cord-350836-1enteev7	184	19	,	,	,
cord-350836-1enteev7	184	20	such	such	JJ
cord-350836-1enteev7	184	21	as	as	IN
cord-350836-1enteev7	184	22	the	the	DT
cord-350836-1enteev7	184	23	DEADbox	deadbox	NN
cord-350836-1enteev7	184	24	helicase	helicase	NN
cord-350836-1enteev7	184	25	3	3	CD
cord-350836-1enteev7	184	26	(	(	-LRB-
cord-350836-1enteev7	184	27	DDX3	DDX3	NNP
cord-350836-1enteev7	184	28	)	)	-RRB-
cord-350836-1enteev7	184	29	(	(	-LRB-
cord-350836-1enteev7	184	30	154	154	CD
cord-350836-1enteev7	184	31	)	)	-RRB-
cord-350836-1enteev7	184	32	.	.	.
cord-350836-1enteev7	185	1	The	the	DT
cord-350836-1enteev7	185	2	activated	activate	VBN
cord-350836-1enteev7	185	3	p	p	NN
cord-350836-1enteev7	185	4	-	-	:
cord-350836-1enteev7	185	5	IRF3	IRF3	NNP
cord-350836-1enteev7	185	6	(	(	-LRB-
cord-350836-1enteev7	185	7	15	15	CD
cord-350836-1enteev7	185	8	)	)	-RRB-
cord-350836-1enteev7	185	9	and	and	CC
cord-350836-1enteev7	185	10	p	p	LS
cord-350836-1enteev7	185	11	-	-	:
cord-350836-1enteev7	185	12	IRF7	IRF7	NNP
cord-350836-1enteev7	185	13	(	(	-LRB-
cord-350836-1enteev7	185	14	14	14	CD
cord-350836-1enteev7	185	15	)	)	-RRB-
cord-350836-1enteev7	185	16	then	then	RB
cord-350836-1enteev7	185	17	translocate	translocate	VB
cord-350836-1enteev7	185	18	into	into	IN
cord-350836-1enteev7	185	19	the	the	DT
cord-350836-1enteev7	185	20	nucleus	nucleus	NN
cord-350836-1enteev7	185	21	and	and	CC
cord-350836-1enteev7	185	22	dimerize	dimerize	NNP
cord-350836-1enteev7	185	23	,	,	,
cord-350836-1enteev7	185	24	where	where	WRB
cord-350836-1enteev7	185	25	they	-PRON-	PRP
cord-350836-1enteev7	185	26	then	then	RB
cord-350836-1enteev7	185	27	act	act	VBP
cord-350836-1enteev7	185	28	as	as	IN
cord-350836-1enteev7	185	29	the	the	DT
cord-350836-1enteev7	185	30	primary	primary	JJ
cord-350836-1enteev7	185	31	transcription	transcription	NN
cord-350836-1enteev7	185	32	factors	factor	NNS
cord-350836-1enteev7	185	33	for	for	IN
cord-350836-1enteev7	185	34	IFNα	IFNα	NNS
cord-350836-1enteev7	185	35	and	and	CC
cord-350836-1enteev7	185	36	IFNβ	IFNβ	NNS
cord-350836-1enteev7	185	37	,	,	,
cord-350836-1enteev7	185	38	respectively	respectively	RB
cord-350836-1enteev7	185	39	.	.	.
cord-350836-1enteev7	186	1	Existing	exist	VBG
cord-350836-1enteev7	186	2	evidence	evidence	NN
cord-350836-1enteev7	186	3	suggests	suggest	VBZ
cord-350836-1enteev7	186	4	that	that	IN
cord-350836-1enteev7	186	5	IFNα	IFNα	NNP
cord-350836-1enteev7	186	6	is	be	VBZ
cord-350836-1enteev7	186	7	more	more	RBR
cord-350836-1enteev7	186	8	primarily	primarily	RB
cord-350836-1enteev7	186	9	produced	produce	VBN
cord-350836-1enteev7	186	10	in	in	IN
cord-350836-1enteev7	186	11	the	the	DT
cord-350836-1enteev7	186	12	earliest	early	JJS
cord-350836-1enteev7	186	13	time	time	NN
cord-350836-1enteev7	186	14	points	point	NNS
cord-350836-1enteev7	186	15	following	follow	VBG
cord-350836-1enteev7	186	16	RIG	rig	NN
cord-350836-1enteev7	186	17	-	-	HYPH
cord-350836-1enteev7	186	18	I	I	NNP
cord-350836-1enteev7	186	19	/	/	SYM
cord-350836-1enteev7	186	20	MDA5	MDA5	NNP
cord-350836-1enteev7	186	21	activation	activation	NN
cord-350836-1enteev7	186	22	,	,	,
cord-350836-1enteev7	186	23	while	while	IN
cord-350836-1enteev7	186	24	IFNβ	IFNβ	NNS
cord-350836-1enteev7	186	25	is	be	VBZ
cord-350836-1enteev7	186	26	produced	produce	VBN
cord-350836-1enteev7	186	27	later	later	RB
cord-350836-1enteev7	186	28	and	and	CC
cord-350836-1enteev7	186	29	is	be	VBZ
cord-350836-1enteev7	186	30	responsible	responsible	JJ
cord-350836-1enteev7	186	31	for	for	IN
cord-350836-1enteev7	186	32	more	more	RBR
cord-350836-1enteev7	186	33	robust	robust	JJ
cord-350836-1enteev7	186	34	anti	anti	JJ
cord-350836-1enteev7	186	35	-	-	JJ
cord-350836-1enteev7	186	36	viral	viral	JJ
cord-350836-1enteev7	186	37	control	control	NN
cord-350836-1enteev7	186	38	throughout	throughout	IN
cord-350836-1enteev7	186	39	the	the	DT
cord-350836-1enteev7	186	40	innate	innate	JJ
cord-350836-1enteev7	186	41	immune	immune	JJ
cord-350836-1enteev7	186	42	response	response	NN
cord-350836-1enteev7	186	43	period	period	NN
cord-350836-1enteev7	186	44	(	(	-LRB-
cord-350836-1enteev7	186	45	155	155	CD
cord-350836-1enteev7	186	46	)	)	-RRB-
cord-350836-1enteev7	186	47	.	.	.
cord-350836-1enteev7	187	1	There	there	EX
cord-350836-1enteev7	187	2	is	be	VBZ
cord-350836-1enteev7	187	3	also	also	RB
cord-350836-1enteev7	187	4	a	a	DT
cord-350836-1enteev7	187	5	distinction	distinction	NN
cord-350836-1enteev7	187	6	between	between	IN
cord-350836-1enteev7	187	7	innate	innate	JJ
cord-350836-1enteev7	187	8	immune	immune	JJ
cord-350836-1enteev7	187	9	cell	cell	NN
cord-350836-1enteev7	187	10	types	type	NNS
cord-350836-1enteev7	187	11	for	for	IN
cord-350836-1enteev7	187	12	IFN1	IFN1	NNP
cord-350836-1enteev7	187	13	production	production	NN
cord-350836-1enteev7	187	14	,	,	,
cord-350836-1enteev7	187	15	as	as	IN
cord-350836-1enteev7	187	16	cells	cell	NNS
cord-350836-1enteev7	187	17	like	like	IN
cord-350836-1enteev7	187	18	fibroblasts	fibroblast	NNS
cord-350836-1enteev7	187	19	and	and	CC
cord-350836-1enteev7	187	20	conventional	conventional	JJ
cord-350836-1enteev7	187	21	dendritic	dendritic	JJ
cord-350836-1enteev7	187	22	cells	cell	NNS
cord-350836-1enteev7	187	23	produce	produce	VBP
cord-350836-1enteev7	187	24	IFNα	IFNα	NNS
cord-350836-1enteev7	187	25	and	and	CC
cord-350836-1enteev7	187	26	IFNβ	IFNβ	NNS
cord-350836-1enteev7	187	27	(	(	-LRB-
cord-350836-1enteev7	187	28	41	41	CD
cord-350836-1enteev7	187	29	,	,	,
cord-350836-1enteev7	187	30	156	156	CD
cord-350836-1enteev7	187	31	)	)	-RRB-
cord-350836-1enteev7	187	32	,	,	,
cord-350836-1enteev7	187	33	while	while	IN
cord-350836-1enteev7	187	34	neutrophils	neutrophil	NNS
cord-350836-1enteev7	187	35	only	only	RB
cord-350836-1enteev7	187	36	produce	produce	VBP
cord-350836-1enteev7	187	37	IFNβ	IFNβ	NNS
cord-350836-1enteev7	187	38	(	(	-LRB-
cord-350836-1enteev7	187	39	157	157	CD
cord-350836-1enteev7	187	40	)	)	-RRB-
cord-350836-1enteev7	187	41	and	and	CC
cord-350836-1enteev7	187	42	plasmacytoid	plasmacytoid	NNP
cord-350836-1enteev7	187	43	dendritic	dendritic	JJ
cord-350836-1enteev7	187	44	cells	cell	NNS
cord-350836-1enteev7	188	1	only	only	RB
cord-350836-1enteev7	188	2	produce	produce	VB
cord-350836-1enteev7	188	3	IFNα	IFNα	NNS
cord-350836-1enteev7	188	4	primarily	primarily	RB
cord-350836-1enteev7	188	5	through	through	IN
cord-350836-1enteev7	188	6	the	the	DT
cord-350836-1enteev7	188	7	TLR	TLR	NNP
cord-350836-1enteev7	188	8	signaling	signal	VBG
cord-350836-1enteev7	188	9	pathways	pathway	NNS
cord-350836-1enteev7	188	10	(	(	-LRB-
cord-350836-1enteev7	188	11	41	41	CD
cord-350836-1enteev7	188	12	,	,	,
cord-350836-1enteev7	188	13	158	158	CD
cord-350836-1enteev7	188	14	)	)	-RRB-
cord-350836-1enteev7	188	15	.	.	.
cord-350836-1enteev7	189	1	Signaling	signal	VBG
cord-350836-1enteev7	189	2	through	through	IN
cord-350836-1enteev7	189	3	RIG	rig	NN
cord-350836-1enteev7	189	4	-	-	:
cord-350836-1enteev7	189	5	I	-PRON-	PRP
cord-350836-1enteev7	189	6	is	be	VBZ
cord-350836-1enteev7	189	7	also	also	RB
cord-350836-1enteev7	189	8	known	know	VBN
cord-350836-1enteev7	189	9	to	to	TO
cord-350836-1enteev7	189	10	be	be	VB
cord-350836-1enteev7	189	11	essential	essential	JJ
cord-350836-1enteev7	189	12	for	for	IN
cord-350836-1enteev7	189	13	the	the	DT
cord-350836-1enteev7	189	14	process	process	NN
cord-350836-1enteev7	189	15	of	of	IN
cord-350836-1enteev7	189	16	TLRmediated	tlrmediate	VBN
cord-350836-1enteev7	189	17	phagocytosis	phagocytosis	NN
cord-350836-1enteev7	189	18	by	by	IN
cord-350836-1enteev7	189	19	macrophages	macrophage	NNS
cord-350836-1enteev7	189	20	(	(	-LRB-
cord-350836-1enteev7	189	21	159	159	CD
cord-350836-1enteev7	189	22	)	)	-RRB-
cord-350836-1enteev7	189	23	.	.	.
cord-350836-1enteev7	190	1	Interferons	interferon	NNS
cord-350836-1enteev7	190	2	are	be	VBP
cord-350836-1enteev7	190	3	then	then	RB
cord-350836-1enteev7	190	4	secreted	secrete	VBN
cord-350836-1enteev7	190	5	out	out	IN
cord-350836-1enteev7	190	6	of	of	IN
cord-350836-1enteev7	190	7	the	the	DT
cord-350836-1enteev7	190	8	cell	cell	NN
cord-350836-1enteev7	190	9	,	,	,
cord-350836-1enteev7	190	10	where	where	WRB
cord-350836-1enteev7	190	11	they	-PRON-	PRP
cord-350836-1enteev7	190	12	bind	bind	VBP
cord-350836-1enteev7	190	13	to	to	IN
cord-350836-1enteev7	190	14	their	-PRON-	PRP$
cord-350836-1enteev7	190	15	own	own	JJ
cord-350836-1enteev7	190	16	receptor	receptor	NN
cord-350836-1enteev7	190	17	(	(	-LRB-
cord-350836-1enteev7	190	18	IFNAR	IFNAR	NNP
cord-350836-1enteev7	190	19	)	)	-RRB-
cord-350836-1enteev7	190	20	and	and	CC
cord-350836-1enteev7	190	21	activate	activate	VB
cord-350836-1enteev7	190	22	the	the	DT
cord-350836-1enteev7	190	23	Janus	Janus	NNP
cord-350836-1enteev7	190	24	kinase	kinase	NN
cord-350836-1enteev7	190	25	/	/	SYM
cord-350836-1enteev7	190	26	Signal	Signal	NNP
cord-350836-1enteev7	190	27	Transducer	Transducer	NNP
cord-350836-1enteev7	190	28	and	and	CC
cord-350836-1enteev7	190	29	Activator	Activator	NNP
cord-350836-1enteev7	190	30	of	of	IN
cord-350836-1enteev7	190	31	Transcription	transcription	NN
cord-350836-1enteev7	190	32	proteins	protein	NNS
cord-350836-1enteev7	190	33	(	(	-LRB-
cord-350836-1enteev7	190	34	JAK	JAK	NNP
cord-350836-1enteev7	190	35	/	/	SYM
cord-350836-1enteev7	190	36	STAT	stat	NN
cord-350836-1enteev7	190	37	)	)	-RRB-
cord-350836-1enteev7	190	38	signaling	signal	VBG
cord-350836-1enteev7	190	39	pathways	pathway	NNS
cord-350836-1enteev7	190	40	,	,	,
cord-350836-1enteev7	190	41	which	which	WDT
cord-350836-1enteev7	190	42	result	result	VBP
cord-350836-1enteev7	190	43	in	in	IN
cord-350836-1enteev7	190	44	a	a	DT
cord-350836-1enteev7	190	45	positive	positive	JJ
cord-350836-1enteev7	190	46	feedback	feedback	NN
cord-350836-1enteev7	190	47	signaling	signal	VBG
cord-350836-1enteev7	190	48	loop	loop	NN
cord-350836-1enteev7	190	49	to	to	IN
cord-350836-1enteev7	190	50	further	further	JJ
cord-350836-1enteev7	190	51	increase	increase	VB
cord-350836-1enteev7	190	52	RIG	rig	NN
cord-350836-1enteev7	190	53	-	-	:
cord-350836-1enteev7	190	54	I/	I/	NNP
cord-350836-1enteev7	191	1	MDA5	mda5	JJ
cord-350836-1enteev7	191	2	expression	expression	NN
cord-350836-1enteev7	191	3	and	and	CC
cord-350836-1enteev7	191	4	activation	activation	NN
cord-350836-1enteev7	191	5	(	(	-LRB-
cord-350836-1enteev7	191	6	160	160	CD
cord-350836-1enteev7	191	7	)	)	-RRB-
cord-350836-1enteev7	191	8	and	and	CC
cord-350836-1enteev7	191	9	IFN1	IFN1	NNP
cord-350836-1enteev7	191	10	production	production	NN
cord-350836-1enteev7	191	11	(	(	-LRB-
cord-350836-1enteev7	191	12	161	161	CD
cord-350836-1enteev7	191	13	,	,	,
cord-350836-1enteev7	191	14	162	162	CD
cord-350836-1enteev7	191	15	)	)	-RRB-
cord-350836-1enteev7	191	16	.	.	.
cord-350836-1enteev7	192	1	Expression	expression	NN
cord-350836-1enteev7	192	2	levels	level	NNS
cord-350836-1enteev7	192	3	of	of	IN
cord-350836-1enteev7	192	4	RIG	rig	NN
cord-350836-1enteev7	192	5	-	-	:
cord-350836-1enteev7	192	6	I	I	NNP
cord-350836-1enteev7	192	7	and	and	CC
cord-350836-1enteev7	192	8	MDA5	MDA5	NNP
cord-350836-1enteev7	192	9	have	have	VBP
cord-350836-1enteev7	192	10	consistently	consistently	RB
cord-350836-1enteev7	192	11	been	be	VBN
cord-350836-1enteev7	192	12	found	find	VBN
cord-350836-1enteev7	192	13	to	to	TO
cord-350836-1enteev7	192	14	be	be	VB
cord-350836-1enteev7	192	15	upregulated	upregulate	VBN
cord-350836-1enteev7	192	16	downstream	downstream	RB
cord-350836-1enteev7	192	17	of	of	IN
cord-350836-1enteev7	192	18	type	type	NN
cord-350836-1enteev7	192	19	I	-PRON-	PRP
cord-350836-1enteev7	192	20	(	(	-LRB-
cord-350836-1enteev7	192	21	163	163	CD
cord-350836-1enteev7	192	22	,	,	,
cord-350836-1enteev7	192	23	164	164	CD
cord-350836-1enteev7	192	24	)	)	-RRB-
cord-350836-1enteev7	192	25	and	and	CC
cord-350836-1enteev7	192	26	type	type	NN
cord-350836-1enteev7	192	27	II	II	NNP
cord-350836-1enteev7	192	28	(	(	-LRB-
cord-350836-1enteev7	192	29	165	165	CD
cord-350836-1enteev7	192	30	,	,	,
cord-350836-1enteev7	192	31	166	166	CD
cord-350836-1enteev7	192	32	)	)	-RRB-
cord-350836-1enteev7	192	33	IFN	IFN	NNP
cord-350836-1enteev7	192	34	signals	signal	VBZ
cord-350836-1enteev7	192	35	.	.	.
cord-350836-1enteev7	193	1	MDA5	mda5	JJ
cord-350836-1enteev7	193	2	upregulation	upregulation	NN
cord-350836-1enteev7	193	3	has	have	VBZ
cord-350836-1enteev7	193	4	additionally	additionally	RB
cord-350836-1enteev7	193	5	been	be	VBN
cord-350836-1enteev7	193	6	found	find	VBN
cord-350836-1enteev7	193	7	to	to	TO
cord-350836-1enteev7	193	8	occur	occur	VB
cord-350836-1enteev7	193	9	independently	independently	RB
cord-350836-1enteev7	193	10	of	of	IN
cord-350836-1enteev7	193	11	cytokine	cytokine	JJ
cord-350836-1enteev7	193	12	expression	expression	NN
cord-350836-1enteev7	193	13	at	at	IN
cord-350836-1enteev7	193	14	least	least	JJS
cord-350836-1enteev7	193	15	during	during	IN
cord-350836-1enteev7	193	16	picornavirus	picornavirus	NNP
cord-350836-1enteev7	193	17	infection	infection	NN
cord-350836-1enteev7	193	18	(	(	-LRB-
cord-350836-1enteev7	193	19	167	167	CD
cord-350836-1enteev7	193	20	)	)	-RRB-
cord-350836-1enteev7	193	21	.	.	.
cord-350836-1enteev7	194	1	One	one	CD
cord-350836-1enteev7	194	2	of	of	IN
cord-350836-1enteev7	194	3	the	the	DT
cord-350836-1enteev7	194	4	most	most	RBS
cord-350836-1enteev7	194	5	obvious	obvious	JJ
cord-350836-1enteev7	194	6	distinctions	distinction	NNS
cord-350836-1enteev7	194	7	between	between	IN
cord-350836-1enteev7	194	8	RIG	rig	NN
cord-350836-1enteev7	194	9	-	-	:
cord-350836-1enteev7	194	10	I	I	NNP
cord-350836-1enteev7	194	11	and	and	CC
cord-350836-1enteev7	194	12	MDA5	MDA5	NNP
cord-350836-1enteev7	194	13	is	be	VBZ
cord-350836-1enteev7	194	14	in	in	IN
cord-350836-1enteev7	194	15	the	the	DT
cord-350836-1enteev7	194	16	RNA	RNA	NNP
cord-350836-1enteev7	194	17	species	specie	NNS
cord-350836-1enteev7	194	18	to	to	TO
cord-350836-1enteev7	194	19	which	which	WDT
cord-350836-1enteev7	194	20	they	-PRON-	PRP
cord-350836-1enteev7	194	21	bind	bind	VBP
cord-350836-1enteev7	194	22	for	for	IN
cord-350836-1enteev7	194	23	activation	activation	NN
cord-350836-1enteev7	194	24	(	(	-LRB-
cord-350836-1enteev7	194	25	Figures	figure	NNS
cord-350836-1enteev7	194	26	1	1	CD
cord-350836-1enteev7	194	27	,	,	,
cord-350836-1enteev7	194	28	5	5	CD
cord-350836-1enteev7	194	29	)	)	-RRB-
cord-350836-1enteev7	194	30	.	.	.
cord-350836-1enteev7	195	1	RIG	rig	NN
cord-350836-1enteev7	195	2	-	-	:
cord-350836-1enteev7	195	3	I	-PRON-	PRP
cord-350836-1enteev7	195	4	has	have	VBZ
cord-350836-1enteev7	195	5	the	the	DT
cord-350836-1enteev7	195	6	highest	high	JJS
cord-350836-1enteev7	195	7	affinity	affinity	NN
cord-350836-1enteev7	195	8	for	for	IN
cord-350836-1enteev7	195	9	short	short	JJ
cord-350836-1enteev7	195	10	dsRNA	dsrna	NN
cord-350836-1enteev7	195	11	that	that	WDT
cord-350836-1enteev7	195	12	is	be	VBZ
cord-350836-1enteev7	195	13	tri	tri	JJ
cord-350836-1enteev7	195	14	-	-	JJ
cord-350836-1enteev7	195	15	phosphorylated	phosphorylated	JJ
cord-350836-1enteev7	195	16	at	at	IN
cord-350836-1enteev7	195	17	the	the	DT
cord-350836-1enteev7	195	18	5	5	CD
cord-350836-1enteev7	195	19	′	′	CD
cord-350836-1enteev7	195	20	end	end	NN
cord-350836-1enteev7	195	21	(	(	-LRB-
cord-350836-1enteev7	195	22	67	67	CD
cord-350836-1enteev7	195	23	-	-	SYM
cord-350836-1enteev7	195	24	75	75	CD
cord-350836-1enteev7	195	25	)	)	-RRB-
cord-350836-1enteev7	195	26	,	,	,
cord-350836-1enteev7	195	27	with	with	IN
cord-350836-1enteev7	195	28	RIG	rig	NN
cord-350836-1enteev7	195	29	-	-	:
cord-350836-1enteev7	195	30	I	-PRON-	PRP
cord-350836-1enteev7	195	31	having	have	VBG
cord-350836-1enteev7	195	32	been	be	VBN
cord-350836-1enteev7	195	33	found	find	VBN
cord-350836-1enteev7	195	34	to	to	TO
cord-350836-1enteev7	195	35	directly	directly	RB
cord-350836-1enteev7	195	36	interact	interact	VB
cord-350836-1enteev7	195	37	with	with	IN
cord-350836-1enteev7	195	38	the	the	DT
cord-350836-1enteev7	195	39	5	5	CD
cord-350836-1enteev7	195	40	′	′	CD
cord-350836-1enteev7	195	41	tri	tri	JJ
cord-350836-1enteev7	195	42	-	-	JJ
cord-350836-1enteev7	195	43	phosphate	phosphate	JJ
cord-350836-1enteev7	195	44	group	group	NN
cord-350836-1enteev7	195	45	of	of	IN
cord-350836-1enteev7	195	46	the	the	DT
cord-350836-1enteev7	195	47	dsRNA	dsrna	NN
cord-350836-1enteev7	195	48	(	(	-LRB-
cord-350836-1enteev7	195	49	71	71	CD
cord-350836-1enteev7	195	50	,	,	,
cord-350836-1enteev7	195	51	73	73	CD
cord-350836-1enteev7	195	52	)	)	-RRB-
cord-350836-1enteev7	195	53	.	.	.
cord-350836-1enteev7	196	1	While	while	IN
cord-350836-1enteev7	196	2	RIG	rig	NN
cord-350836-1enteev7	196	3	-	-	:
cord-350836-1enteev7	196	4	I	-PRON-	PRP
cord-350836-1enteev7	196	5	can	can	MD
cord-350836-1enteev7	196	6	bind	bind	VB
cord-350836-1enteev7	196	7	to	to	IN
cord-350836-1enteev7	196	8	ss-5	ss-5	NNP
cord-350836-1enteev7	196	9	′	′	CD
cord-350836-1enteev7	196	10	tri	tri	JJ
cord-350836-1enteev7	196	11	-	-	JJ
cord-350836-1enteev7	196	12	phosphorylated	phosphorylated	JJ
cord-350836-1enteev7	196	13	RNA	RNA	NNP
cord-350836-1enteev7	196	14	(	(	-LRB-
cord-350836-1enteev7	196	15	69	69	CD
cord-350836-1enteev7	196	16	)	)	-RRB-
cord-350836-1enteev7	196	17	,	,	,
cord-350836-1enteev7	196	18	RIG	rig	NN
cord-350836-1enteev7	196	19	-	-	:
cord-350836-1enteev7	196	20	I	-PRON-	PRP
cord-350836-1enteev7	196	21	can	can	MD
cord-350836-1enteev7	196	22	not	not	RB
cord-350836-1enteev7	196	23	be	be	VB
cord-350836-1enteev7	196	24	activated	activate	VBN
cord-350836-1enteev7	196	25	by	by	IN
cord-350836-1enteev7	196	26	it	-PRON-	PRP
cord-350836-1enteev7	196	27	(	(	-LRB-
cord-350836-1enteev7	196	28	69	69	CD
cord-350836-1enteev7	196	29	,	,	,
cord-350836-1enteev7	196	30	168	168	CD
cord-350836-1enteev7	196	31	,	,	,
cord-350836-1enteev7	196	32	169	169	CD
cord-350836-1enteev7	196	33	)	)	-RRB-
cord-350836-1enteev7	196	34	,	,	,
cord-350836-1enteev7	196	35	likely	likely	RB
cord-350836-1enteev7	196	36	due	due	IN
cord-350836-1enteev7	196	37	to	to	IN
cord-350836-1enteev7	196	38	a	a	DT
cord-350836-1enteev7	196	39	conformational	conformational	JJ
cord-350836-1enteev7	196	40	need	need	NN
cord-350836-1enteev7	196	41	to	to	TO
cord-350836-1enteev7	196	42	recognize	recognize	VB
cord-350836-1enteev7	196	43	double	double	RB
cord-350836-1enteev7	196	44	-	-	HYPH
cord-350836-1enteev7	196	45	stranded	strand	VBN
cord-350836-1enteev7	196	46	RNA	RNA	NNP
cord-350836-1enteev7	196	47	.	.	.
cord-350836-1enteev7	197	1	As	as	IN
cord-350836-1enteev7	197	2	a	a	DT
cord-350836-1enteev7	197	3	result	result	NN
cord-350836-1enteev7	197	4	,	,	,
cord-350836-1enteev7	197	5	RIG	rig	NN
cord-350836-1enteev7	197	6	-	-	:
cord-350836-1enteev7	197	7	I	-PRON-	PRP
cord-350836-1enteev7	197	8	is	be	VBZ
cord-350836-1enteev7	197	9	greatly	greatly	RB
cord-350836-1enteev7	197	10	attenuated	attenuate	VBN
cord-350836-1enteev7	197	11	by	by	IN
cord-350836-1enteev7	197	12	a	a	DT
cord-350836-1enteev7	197	13	5	5	CD
cord-350836-1enteev7	197	14	′	′	CD
cord-350836-1enteev7	197	15	overhang	overhang	NN
cord-350836-1enteev7	197	16	as	as	RB
cord-350836-1enteev7	197	17	well	well	RB
cord-350836-1enteev7	197	18	as	as	IN
cord-350836-1enteev7	197	19	those	those	DT
cord-350836-1enteev7	197	20	with	with	IN
cord-350836-1enteev7	197	21	a	a	DT
cord-350836-1enteev7	197	22	3	3	CD
cord-350836-1enteev7	197	23	′	′	CD
cord-350836-1enteev7	197	24	overhanging	overhang	VBG
cord-350836-1enteev7	197	25	the	the	DT
cord-350836-1enteev7	197	26	5	5	CD
cord-350836-1enteev7	197	27	′	′	CD
cord-350836-1enteev7	197	28	tri	tri	JJ
cord-350836-1enteev7	197	29	-	-	JJ
cord-350836-1enteev7	197	30	phosphate	phosphate	JJ
cord-350836-1enteev7	197	31	end	end	NN
cord-350836-1enteev7	197	32	(	(	-LRB-
cord-350836-1enteev7	197	33	170	170	CD
cord-350836-1enteev7	197	34	)	)	-RRB-
cord-350836-1enteev7	197	35	.	.	.
cord-350836-1enteev7	198	1	In	in	IN
cord-350836-1enteev7	198	2	fact	fact	NN
cord-350836-1enteev7	198	3	,	,	,
cord-350836-1enteev7	198	4	a	a	DT
cord-350836-1enteev7	198	5	single	single	JJ
cord-350836-1enteev7	198	6	unpaired	unpaired	JJ
cord-350836-1enteev7	198	7	5	5	CD
cord-350836-1enteev7	198	8	′	′	CD
cord-350836-1enteev7	198	9	triphosphorylated	triphosphorylate	VBN
cord-350836-1enteev7	198	10	nucleotide	nucleotide	NN
cord-350836-1enteev7	198	11	is	be	VBZ
cord-350836-1enteev7	198	12	sufficient	sufficient	JJ
cord-350836-1enteev7	198	13	to	to	TO
cord-350836-1enteev7	198	14	competitively	competitively	RB
cord-350836-1enteev7	198	15	inhibit	inhibit	VB
cord-350836-1enteev7	198	16	RIG	rig	NN
cord-350836-1enteev7	198	17	-	-	:
cord-350836-1enteev7	198	18	I	I	NNP
cord-350836-1enteev7	198	19	,	,	,
cord-350836-1enteev7	198	20	which	which	WDT
cord-350836-1enteev7	198	21	has	have	VBZ
cord-350836-1enteev7	198	22	been	be	VBN
cord-350836-1enteev7	198	23	exploited	exploit	VBN
cord-350836-1enteev7	198	24	by	by	IN
cord-350836-1enteev7	198	25	RNA	RNA	NNP
cord-350836-1enteev7	198	26	viruses	virus	NNS
cord-350836-1enteev7	198	27	to	to	TO
cord-350836-1enteev7	198	28	evade	evade	VB
cord-350836-1enteev7	198	29	RIG	rig	NN
cord-350836-1enteev7	198	30	-	-	:
cord-350836-1enteev7	198	31	I	-PRON-	PRP
cord-350836-1enteev7	198	32	recognition	recognition	NN
cord-350836-1enteev7	198	33	and	and	CC
cord-350836-1enteev7	198	34	IFN1	IFN1	NNP
cord-350836-1enteev7	198	35	signaling	signal	VBG
cord-350836-1enteev7	198	36	(	(	-LRB-
cord-350836-1enteev7	198	37	171	171	CD
cord-350836-1enteev7	198	38	)	)	-RRB-
cord-350836-1enteev7	198	39	.	.	.
cord-350836-1enteev7	199	1	The	the	DT
cord-350836-1enteev7	199	2	unique	unique	JJ
cord-350836-1enteev7	199	3	preference	preference	NN
cord-350836-1enteev7	199	4	of	of	IN
cord-350836-1enteev7	199	5	RIG	rig	NN
cord-350836-1enteev7	199	6	-	-	:
cord-350836-1enteev7	199	7	I	-PRON-	PRP
cord-350836-1enteev7	199	8	for	for	IN
cord-350836-1enteev7	199	9	5	5	CD
cord-350836-1enteev7	199	10	′	′	CD
cord-350836-1enteev7	199	11	tri	tri	JJ
cord-350836-1enteev7	199	12	-	-	JJ
cord-350836-1enteev7	199	13	phosphorylated	phosphorylated	JJ
cord-350836-1enteev7	199	14	RNA	RNA	NNP
cord-350836-1enteev7	199	15	can	can	MD
cord-350836-1enteev7	199	16	be	be	VB
cord-350836-1enteev7	199	17	explained	explain	VBN
cord-350836-1enteev7	199	18	by	by	IN
cord-350836-1enteev7	199	19	the	the	DT
cord-350836-1enteev7	199	20	specific	specific	JJ
cord-350836-1enteev7	199	21	orientation	orientation	NN
cord-350836-1enteev7	199	22	that	that	WDT
cord-350836-1enteev7	199	23	the	the	DT
cord-350836-1enteev7	199	24	RIG	rig	NN
cord-350836-1enteev7	199	25	-	-	:
cord-350836-1enteev7	199	26	I	I	NNP
cord-350836-1enteev7	199	27	C	C	NNP
cord-350836-1enteev7	199	28	terminus	terminus	NN
cord-350836-1enteev7	199	29	adopts	adopt	VBZ
cord-350836-1enteev7	199	30	when	when	WRB
cord-350836-1enteev7	199	31	directly	directly	RB
cord-350836-1enteev7	199	32	interacting	interact	VBG
cord-350836-1enteev7	199	33	with	with	IN
cord-350836-1enteev7	199	34	the	the	DT
cord-350836-1enteev7	199	35	5	5	CD
cord-350836-1enteev7	199	36	′	′	CD
cord-350836-1enteev7	199	37	tri	tri	JJ
cord-350836-1enteev7	199	38	-	-	JJ
cord-350836-1enteev7	199	39	phosphate	phosphate	JJ
cord-350836-1enteev7	199	40	group	group	NN
cord-350836-1enteev7	199	41	of	of	IN
cord-350836-1enteev7	199	42	the	the	DT
cord-350836-1enteev7	199	43	5	5	CD
cord-350836-1enteev7	199	44	′	′	CD
cord-350836-1enteev7	199	45	tri	tri	JJ
cord-350836-1enteev7	199	46	-	-	JJ
cord-350836-1enteev7	199	47	phosphorylated	phosphorylated	JJ
cord-350836-1enteev7	199	48	dsRNA	dsrna	NN
cord-350836-1enteev7	199	49	(	(	-LRB-
cord-350836-1enteev7	199	50	71	71	CD
cord-350836-1enteev7	199	51	,	,	,
cord-350836-1enteev7	199	52	73	73	CD
cord-350836-1enteev7	199	53	)	)	-RRB-
cord-350836-1enteev7	199	54	as	as	IN
cord-350836-1enteev7	199	55	compared	compare	VBN
cord-350836-1enteev7	199	56	to	to	IN
cord-350836-1enteev7	199	57	unphosphorylated	unphosphorylated	JJ
cord-350836-1enteev7	199	58	blunt	blunt	JJ
cord-350836-1enteev7	199	59	-	-	HYPH
cord-350836-1enteev7	199	60	ended	end	VBN
cord-350836-1enteev7	199	61	dsRNA	dsrna	NN
cord-350836-1enteev7	199	62	(	(	-LRB-
cord-350836-1enteev7	199	63	172	172	CD
cord-350836-1enteev7	199	64	)	)	-RRB-
cord-350836-1enteev7	199	65	.	.	.
cord-350836-1enteev7	200	1	The	the	DT
cord-350836-1enteev7	200	2	minimally	minimally	RB
cord-350836-1enteev7	200	3	required	required	JJ
cord-350836-1enteev7	200	4	and	and	CC
cord-350836-1enteev7	200	5	exclusionary	exclusionary	JJ
cord-350836-1enteev7	200	6	features	feature	NNS
cord-350836-1enteev7	200	7	of	of	IN
cord-350836-1enteev7	200	8	the	the	DT
cord-350836-1enteev7	200	9	5	5	CD
cord-350836-1enteev7	200	10	′	′	CD
cord-350836-1enteev7	200	11	and	and	CC
cord-350836-1enteev7	200	12	3	3	CD
cord-350836-1enteev7	200	13	′	′	CD
cord-350836-1enteev7	200	14	dsRNA	dsrna	NN
cord-350836-1enteev7	200	15	ends	end	NNS
cord-350836-1enteev7	200	16	for	for	IN
cord-350836-1enteev7	200	17	RIG	rig	NN
cord-350836-1enteev7	200	18	-	-	:
cord-350836-1enteev7	200	19	I	-PRON-	PRP
cord-350836-1enteev7	200	20	activation	activation	NN
cord-350836-1enteev7	200	21	have	have	VBP
cord-350836-1enteev7	200	22	proven	prove	VBN
cord-350836-1enteev7	200	23	to	to	TO
cord-350836-1enteev7	200	24	be	be	VB
cord-350836-1enteev7	200	25	complex	complex	JJ
cord-350836-1enteev7	200	26	.	.	.
cord-350836-1enteev7	201	1	Certain	certain	JJ
cord-350836-1enteev7	201	2	studies	study	NNS
cord-350836-1enteev7	201	3	suggest	suggest	VBP
cord-350836-1enteev7	201	4	that	that	IN
cord-350836-1enteev7	201	5	a	a	DT
cord-350836-1enteev7	201	6	5	5	CD
cord-350836-1enteev7	201	7	′	′	CD
cord-350836-1enteev7	201	8	diphosphate	diphosphate	NN
cord-350836-1enteev7	201	9	group	group	NN
cord-350836-1enteev7	201	10	is	be	VBZ
cord-350836-1enteev7	201	11	the	the	DT
cord-350836-1enteev7	201	12	minimum	minimum	JJ
cord-350836-1enteev7	201	13	feature	feature	NN
cord-350836-1enteev7	201	14	required	require	VBN
cord-350836-1enteev7	201	15	for	for	IN
cord-350836-1enteev7	201	16	RIG	rig	NN
cord-350836-1enteev7	201	17	-	-	:
cord-350836-1enteev7	201	18	I	i	NN
cord-350836-1enteev7	201	19	binding	bind	VBG
cord-350836-1enteev7	201	20	and	and	CC
cord-350836-1enteev7	201	21	activation	activation	NN
cord-350836-1enteev7	201	22	,	,	,
cord-350836-1enteev7	201	23	with	with	IN
cord-350836-1enteev7	201	24	5	5	CD
cord-350836-1enteev7	201	25	′	′	CD
cord-350836-1enteev7	201	26	monophosphate	monophosphate	NN
cord-350836-1enteev7	201	27	dsRNA	dsrna	NN
cord-350836-1enteev7	201	28	failing	fail	VBG
cord-350836-1enteev7	201	29	to	to	TO
cord-350836-1enteev7	201	30	productively	productively	RB
cord-350836-1enteev7	201	31	activate	activate	VB
cord-350836-1enteev7	201	32	RIG	rig	NN
cord-350836-1enteev7	201	33	-	-	:
cord-350836-1enteev7	201	34	I	-PRON-	PRP
cord-350836-1enteev7	201	35	as	as	IN
cord-350836-1enteev7	201	36	compared	compare	VBN
cord-350836-1enteev7	201	37	to	to	IN
cord-350836-1enteev7	201	38	5	5	CD
cord-350836-1enteev7	201	39	′	′	CD
cord-350836-1enteev7	201	40	di	di	NN
cord-350836-1enteev7	201	41	and	and	CC
cord-350836-1enteev7	201	42	tri	tri	JJ
cord-350836-1enteev7	201	43	-	-	JJ
cord-350836-1enteev7	201	44	phosphate	phosphate	JJ
cord-350836-1enteev7	201	45	dsRNA	dsRNA	NNS
cord-350836-1enteev7	201	46	(	(	-LRB-
cord-350836-1enteev7	201	47	173	173	CD
cord-350836-1enteev7	201	48	)	)	-RRB-
cord-350836-1enteev7	201	49	.	.	.
cord-350836-1enteev7	202	1	Frontiers	frontier	NNS
cord-350836-1enteev7	202	2	in	in	IN
cord-350836-1enteev7	202	3	Immunology	Immunology	NNP
cord-350836-1enteev7	202	4	|	|	NNP
cord-350836-1enteev7	202	5	www.frontiersin.org	www.frontiersin.org	NN
cord-350836-1enteev7	203	1	Additionally	additionally	RB
cord-350836-1enteev7	203	2	,	,	,
cord-350836-1enteev7	203	3	RIG	rig	NN
cord-350836-1enteev7	203	4	-	-	:
cord-350836-1enteev7	203	5	I	-PRON-	PRP
cord-350836-1enteev7	203	6	poorly	poorly	RB
cord-350836-1enteev7	203	7	distinguishes	distinguish	VBZ
cord-350836-1enteev7	203	8	between	between	IN
cord-350836-1enteev7	203	9	dsRNAs	dsRNAs	NNP
cord-350836-1enteev7	203	10	with	with	IN
cord-350836-1enteev7	203	11	either	either	DT
cord-350836-1enteev7	203	12	5	5	CD
cord-350836-1enteev7	203	13	′	′	CD
cord-350836-1enteev7	203	14	tri	tri	JJ
cord-350836-1enteev7	203	15	-	-	NN
cord-350836-1enteev7	203	16	phosphate	phosphate	NN
cord-350836-1enteev7	203	17	and	and	CC
cord-350836-1enteev7	203	18	5	5	CD
cord-350836-1enteev7	203	19	′	′	CD
cord-350836-1enteev7	203	20	diphosphate	diphosphate	NN
cord-350836-1enteev7	203	21	group	group	NN
cord-350836-1enteev7	203	22	.	.	.
cord-350836-1enteev7	204	1	When	when	WRB
cord-350836-1enteev7	204	2	the	the	DT
cord-350836-1enteev7	204	3	free	free	JJ
cord-350836-1enteev7	204	4	energies	energy	NNS
cord-350836-1enteev7	204	5	of	of	IN
cord-350836-1enteev7	204	6	each	each	DT
cord-350836-1enteev7	204	7	interaction	interaction	NN
cord-350836-1enteev7	204	8	are	be	VBP
cord-350836-1enteev7	204	9	calculated	calculate	VBN
cord-350836-1enteev7	204	10	,	,	,
cord-350836-1enteev7	204	11	the	the	DT
cord-350836-1enteev7	204	12	affinity	affinity	NN
cord-350836-1enteev7	204	13	for	for	IN
cord-350836-1enteev7	204	14	5	5	CD
cord-350836-1enteev7	204	15	′	′	CD
cord-350836-1enteev7	204	16	triphosphate	triphosphate	NN
cord-350836-1enteev7	204	17	being	be	VBG
cord-350836-1enteev7	204	18	lowered	lower	VBN
cord-350836-1enteev7	204	19	by	by	IN
cord-350836-1enteev7	204	20	disassociation	disassociation	NN
cord-350836-1enteev7	204	21	of	of	IN
cord-350836-1enteev7	204	22	magnesium	magnesium	NN
cord-350836-1enteev7	204	23	from	from	IN
cord-350836-1enteev7	204	24	the	the	DT
cord-350836-1enteev7	204	25	RIG	rig	NN
cord-350836-1enteev7	204	26	-	-	HYPH
cord-350836-1enteev7	204	27	I	I	NNP
cord-350836-1enteev7	204	28	/	/	,
cord-350836-1enteev7	204	29	dsRNA	dsrna	NN
cord-350836-1enteev7	204	30	complex	complex	NN
cord-350836-1enteev7	204	31	.	.	.
cord-350836-1enteev7	205	1	Both	both	DT
cord-350836-1enteev7	205	2	are	be	VBP
cord-350836-1enteev7	205	3	significantly	significantly	RB
cord-350836-1enteev7	205	4	more	more	RBR
cord-350836-1enteev7	205	5	favorable	favorable	JJ
cord-350836-1enteev7	205	6	for	for	IN
cord-350836-1enteev7	205	7	binding	bind	VBG
cord-350836-1enteev7	205	8	RIG	rig	NN
cord-350836-1enteev7	205	9	-	-	:
cord-350836-1enteev7	205	10	I	-PRON-	PRP
cord-350836-1enteev7	205	11	monophosphate	monophosphate	VBP
cord-350836-1enteev7	205	12	dsRNA	dsrna	NN
cord-350836-1enteev7	205	13	(	(	-LRB-
cord-350836-1enteev7	205	14	174	174	CD
cord-350836-1enteev7	205	15	)	)	-RRB-
cord-350836-1enteev7	205	16	.	.	.
cord-350836-1enteev7	206	1	This	this	DT
cord-350836-1enteev7	206	2	similarity	similarity	NN
cord-350836-1enteev7	206	3	in	in	IN
cord-350836-1enteev7	206	4	affinity	affinity	NN
cord-350836-1enteev7	206	5	appears	appear	VBZ
cord-350836-1enteev7	206	6	to	to	TO
cord-350836-1enteev7	206	7	be	be	VB
cord-350836-1enteev7	206	8	important	important	JJ
cord-350836-1enteev7	206	9	in	in	IN
cord-350836-1enteev7	206	10	the	the	DT
cord-350836-1enteev7	206	11	context	context	NN
cord-350836-1enteev7	206	12	of	of	IN
cord-350836-1enteev7	206	13	infection	infection	NN
cord-350836-1enteev7	206	14	with	with	IN
cord-350836-1enteev7	206	15	viruses	virus	NNS
cord-350836-1enteev7	206	16	that	that	WDT
cord-350836-1enteev7	206	17	produce	produce	VBP
cord-350836-1enteev7	206	18	5	5	CD
cord-350836-1enteev7	206	19	′	′	CD
cord-350836-1enteev7	206	20	diphosphate	diphosphate	NN
cord-350836-1enteev7	206	21	RNAs	rna	NNS
cord-350836-1enteev7	206	22	,	,	,
cord-350836-1enteev7	206	23	such	such	JJ
cord-350836-1enteev7	206	24	as	as	IN
cord-350836-1enteev7	206	25	reoviruses	reovirus	NNS
cord-350836-1enteev7	206	26	(	(	-LRB-
cord-350836-1enteev7	206	27	173	173	CD
cord-350836-1enteev7	206	28	)	)	-RRB-
cord-350836-1enteev7	206	29	.	.	.
cord-350836-1enteev7	207	1	Likewise	likewise	RB
cord-350836-1enteev7	207	2	,	,	,
cord-350836-1enteev7	207	3	the	the	DT
cord-350836-1enteev7	207	4	difference	difference	NN
cord-350836-1enteev7	207	5	of	of	IN
cord-350836-1enteev7	207	6	energic	energic	JJ
cord-350836-1enteev7	207	7	binding	binding	NN
cord-350836-1enteev7	207	8	between	between	IN
cord-350836-1enteev7	207	9	monophosphate	monophosphate	NN
cord-350836-1enteev7	207	10	dsRNA	dsrna	NN
cord-350836-1enteev7	207	11	and	and	CC
cord-350836-1enteev7	207	12	bi	bi	JJ
cord-350836-1enteev7	207	13	-	-	HYPH
cord-350836-1enteev7	207	14	and	and	CC
cord-350836-1enteev7	207	15	triphosphate	triphosphate	NNP
cord-350836-1enteev7	207	16	dsRNAs	dsRNAs	NNP
cord-350836-1enteev7	207	17	is	be	VBZ
cord-350836-1enteev7	207	18	likely	likely	RB
cord-350836-1enteev7	207	19	important	important	JJ
cord-350836-1enteev7	207	20	for	for	IN
cord-350836-1enteev7	207	21	distinction	distinction	NN
cord-350836-1enteev7	207	22	between	between	IN
cord-350836-1enteev7	207	23	self	self	NN
cord-350836-1enteev7	207	24	(	(	-LRB-
cord-350836-1enteev7	207	25	host	host	NN
cord-350836-1enteev7	207	26	)	)	-RRB-
cord-350836-1enteev7	207	27	and	and	CC
cord-350836-1enteev7	207	28	non	non	JJ
cord-350836-1enteev7	207	29	-	-	JJ
cord-350836-1enteev7	207	30	self	self	JJ
cord-350836-1enteev7	207	31	(	(	-LRB-
cord-350836-1enteev7	207	32	foreign	foreign	JJ
cord-350836-1enteev7	207	33	)	)	-RRB-
cord-350836-1enteev7	207	34	RNA	RNA	NNP
cord-350836-1enteev7	207	35	,	,	,
cord-350836-1enteev7	207	36	the	the	DT
cord-350836-1enteev7	207	37	mechanisms	mechanism	NNS
cord-350836-1enteev7	207	38	of	of	IN
cord-350836-1enteev7	207	39	which	which	WDT
cord-350836-1enteev7	207	40	will	will	MD
cord-350836-1enteev7	207	41	be	be	VB
cord-350836-1enteev7	207	42	discussed	discuss	VBN
cord-350836-1enteev7	207	43	in	in	IN
cord-350836-1enteev7	207	44	detail	detail	NN
cord-350836-1enteev7	207	45	below	below	RB
cord-350836-1enteev7	207	46	.	.	.
cord-350836-1enteev7	208	1	The	the	DT
cord-350836-1enteev7	208	2	ATP	ATP	NNP
cord-350836-1enteev7	208	3	hydrolysis	hydrolysis	NN
cord-350836-1enteev7	208	4	functions	function	NNS
cord-350836-1enteev7	208	5	of	of	IN
cord-350836-1enteev7	208	6	RIG	rig	NN
cord-350836-1enteev7	208	7	-	-	:
cord-350836-1enteev7	208	8	I	-PRON-	PRP
cord-350836-1enteev7	208	9	have	have	VBP
cord-350836-1enteev7	208	10	been	be	VBN
cord-350836-1enteev7	208	11	shown	show	VBN
cord-350836-1enteev7	208	12	to	to	TO
cord-350836-1enteev7	208	13	drive	drive	VB
cord-350836-1enteev7	208	14	rapid	rapid	JJ
cord-350836-1enteev7	208	15	disassociation	disassociation	NN
cord-350836-1enteev7	208	16	from	from	IN
cord-350836-1enteev7	208	17	certain	certain	JJ
cord-350836-1enteev7	208	18	RNA	RNA	NNP
cord-350836-1enteev7	208	19	features	feature	NNS
cord-350836-1enteev7	208	20	,	,	,
cord-350836-1enteev7	208	21	such	such	JJ
cord-350836-1enteev7	208	22	as	as	IN
cord-350836-1enteev7	208	23	5	5	CD
cord-350836-1enteev7	208	24	′	′	CD
cord-350836-1enteev7	208	25	monophosphate	monophosphate	NN
cord-350836-1enteev7	208	26	dsRNA	dsrna	NN
cord-350836-1enteev7	208	27	(	(	-LRB-
cord-350836-1enteev7	208	28	174	174	CD
cord-350836-1enteev7	208	29	,	,	,
cord-350836-1enteev7	208	30	175	175	CD
cord-350836-1enteev7	208	31	)	)	-RRB-
cord-350836-1enteev7	208	32	and	and	CC
cord-350836-1enteev7	208	33	5	5	CD
cord-350836-1enteev7	208	34	′	′	CD
cord-350836-1enteev7	209	1	OH	oh	UH
cord-350836-1enteev7	209	2	RNA	RNA	NNP
cord-350836-1enteev7	209	3	(	(	-LRB-
cord-350836-1enteev7	209	4	144	144	CD
cord-350836-1enteev7	209	5	,	,	,
cord-350836-1enteev7	209	6	176	176	CD
cord-350836-1enteev7	209	7	)	)	-RRB-
cord-350836-1enteev7	209	8	,	,	,
cord-350836-1enteev7	209	9	which	which	WDT
cord-350836-1enteev7	209	10	is	be	VBZ
cord-350836-1enteev7	209	11	particularly	particularly	RB
cord-350836-1enteev7	209	12	important	important	JJ
cord-350836-1enteev7	209	13	for	for	IN
cord-350836-1enteev7	209	14	5	5	CD
cord-350836-1enteev7	209	15	′	′	CD
cord-350836-1enteev7	209	16	monophosphate	monophosphate	NN
cord-350836-1enteev7	209	17	dsRNA	dsrna	NN
cord-350836-1enteev7	209	18	because	because	IN
cord-350836-1enteev7	209	19	it	-PRON-	PRP
cord-350836-1enteev7	209	20	is	be	VBZ
cord-350836-1enteev7	209	21	found	find	VBN
cord-350836-1enteev7	209	22	in	in	IN
cord-350836-1enteev7	209	23	mRNA	mrna	NN
cord-350836-1enteev7	209	24	after	after	IN
cord-350836-1enteev7	209	25	decapping	decapping	NN
cord-350836-1enteev7	209	26	during	during	IN
cord-350836-1enteev7	209	27	the	the	DT
cord-350836-1enteev7	209	28	mRNA	mRNA	NNP
cord-350836-1enteev7	209	29	degradation	degradation	NN
cord-350836-1enteev7	209	30	process	process	NN
cord-350836-1enteev7	209	31	(	(	-LRB-
cord-350836-1enteev7	209	32	177	177	CD
cord-350836-1enteev7	209	33	)	)	-RRB-
cord-350836-1enteev7	209	34	.	.	.
cord-350836-1enteev7	210	1	On	on	IN
cord-350836-1enteev7	210	2	the	the	DT
cord-350836-1enteev7	210	3	other	other	JJ
cord-350836-1enteev7	210	4	hand	hand	NN
cord-350836-1enteev7	210	5	,	,	,
cord-350836-1enteev7	210	6	other	other	JJ
cord-350836-1enteev7	210	7	studies	study	NNS
cord-350836-1enteev7	210	8	have	have	VBP
cord-350836-1enteev7	210	9	shown	show	VBN
cord-350836-1enteev7	210	10	that	that	IN
cord-350836-1enteev7	210	11	RIG	rig	NN
cord-350836-1enteev7	210	12	-	-	:
cord-350836-1enteev7	210	13	I	-PRON-	PRP
cord-350836-1enteev7	210	14	can	can	MD
cord-350836-1enteev7	210	15	interact	interact	VB
cord-350836-1enteev7	210	16	with	with	IN
cord-350836-1enteev7	210	17	monophosphate	monophosphate	NN
cord-350836-1enteev7	210	18	dsRNA	dsrna	JJ
cord-350836-1enteev7	210	19	to	to	IN
cord-350836-1enteev7	210	20	a	a	DT
cord-350836-1enteev7	210	21	certain	certain	JJ
cord-350836-1enteev7	210	22	degree	degree	NN
cord-350836-1enteev7	210	23	,	,	,
cord-350836-1enteev7	210	24	as	as	IN
cord-350836-1enteev7	210	25	has	have	VBZ
cord-350836-1enteev7	210	26	been	be	VBN
cord-350836-1enteev7	210	27	found	find	VBN
cord-350836-1enteev7	210	28	to	to	TO
cord-350836-1enteev7	210	29	be	be	VB
cord-350836-1enteev7	210	30	the	the	DT
cord-350836-1enteev7	210	31	case	case	NN
cord-350836-1enteev7	210	32	for	for	IN
cord-350836-1enteev7	210	33	short	short	JJ
cord-350836-1enteev7	210	34	synthetic	synthetic	JJ
cord-350836-1enteev7	210	35	dsRNA	dsrna	NN
cord-350836-1enteev7	210	36	with	with	IN
cord-350836-1enteev7	210	37	a	a	DT
cord-350836-1enteev7	210	38	5	5	CD
cord-350836-1enteev7	210	39	′	′	CD
cord-350836-1enteev7	210	40	and	and	CC
cord-350836-1enteev7	210	41	3	3	CD
cord-350836-1enteev7	210	42	′	′	CD
cord-350836-1enteev7	210	43	monophosphate	monophosphate	NN
cord-350836-1enteev7	210	44	group	group	NN
cord-350836-1enteev7	210	45	(	(	-LRB-
cord-350836-1enteev7	210	46	69	69	CD
cord-350836-1enteev7	210	47	)	)	-RRB-
cord-350836-1enteev7	210	48	,	,	.
cord-350836-1enteev7	211	1	poly(I	poly(I	NNS
cord-350836-1enteev7	211	2	:	:	:
cord-350836-1enteev7	211	3	C	C	NNP
cord-350836-1enteev7	211	4	)	)	-RRB-
cord-350836-1enteev7	211	5	digested	digest	VBN
cord-350836-1enteev7	211	6	with	with	IN
cord-350836-1enteev7	211	7	RNase	RNase	NNP
cord-350836-1enteev7	211	8	III	III	NNP
cord-350836-1enteev7	211	9	(	(	-LRB-
cord-350836-1enteev7	211	10	76	76	CD
cord-350836-1enteev7	211	11	)	)	-RRB-
cord-350836-1enteev7	211	12	[	[	-LRB-
cord-350836-1enteev7	211	13	which	which	WDT
cord-350836-1enteev7	211	14	generates	generate	VBZ
cord-350836-1enteev7	211	15	5	5	CD
cord-350836-1enteev7	211	16	′	′	CD
cord-350836-1enteev7	211	17	mono	mono	NN
cord-350836-1enteev7	211	18	-	-	HYPH
cord-350836-1enteev7	211	19	phosphate/3	phosphate/3	JJ
cord-350836-1enteev7	212	1	′	′	CD
cord-350836-1enteev7	212	2	-OH	-oh	NN
cord-350836-1enteev7	212	3	dsRNA	dsrna	NN
cord-350836-1enteev7	213	1	(	(	-LRB-
cord-350836-1enteev7	213	2	178	178	CD
cord-350836-1enteev7	213	3	)	)	-RRB-
cord-350836-1enteev7	213	4	]	]	-RRB-
cord-350836-1enteev7	214	1	and	and	CC
cord-350836-1enteev7	214	2	HCV	HCV	NNP
cord-350836-1enteev7	214	3	RNA	RNA	NNP
cord-350836-1enteev7	214	4	(	(	-LRB-
cord-350836-1enteev7	214	5	179	179	CD
cord-350836-1enteev7	214	6	)	)	-RRB-
cord-350836-1enteev7	214	7	and	and	CC
cord-350836-1enteev7	214	8	mitochondrial	mitochondrial	NN
cord-350836-1enteev7	214	9	RNA	RNA	NNP
cord-350836-1enteev7	214	10	[	[	-LRB-
cord-350836-1enteev7	214	11	in	in	IN
cord-350836-1enteev7	214	12	the	the	DT
cord-350836-1enteev7	214	13	p53	p53	NN
cord-350836-1enteev7	214	14	deficient	deficient	JJ
cord-350836-1enteev7	214	15	mice	mouse	NNS
cord-350836-1enteev7	214	16	(	(	-LRB-
cord-350836-1enteev7	214	17	180	180	CD
cord-350836-1enteev7	214	18	)	)	-RRB-
cord-350836-1enteev7	214	19	]	]	-RRB-
cord-350836-1enteev7	214	20	digested	digest	VBN
cord-350836-1enteev7	214	21	with	with	IN
cord-350836-1enteev7	214	22	RNase	RNase	NNP
cord-350836-1enteev7	214	23	L	L	NNP
cord-350836-1enteev7	214	24	[	[	-LRB-
cord-350836-1enteev7	214	25	which	which	WDT
cord-350836-1enteev7	214	26	produces	produce	VBZ
cord-350836-1enteev7	214	27	5	5	CD
cord-350836-1enteev7	214	28	′	′	CD
cord-350836-1enteev7	214	29	OH	oh	UH
cord-350836-1enteev7	214	30	and	and	CC
cord-350836-1enteev7	214	31	3	3	CD
cord-350836-1enteev7	214	32	′	′	CD
cord-350836-1enteev7	214	33	mono	mono	NN
cord-350836-1enteev7	214	34	-	-	HYPH
cord-350836-1enteev7	214	35	phosphate	phosphate	NNP
cord-350836-1enteev7	214	36	dsRNA	dsrna	NN
cord-350836-1enteev7	214	37	at	at	IN
cord-350836-1enteev7	214	38	subnanomolar	subnanomolar	JJ
cord-350836-1enteev7	214	39	levels	level	NNS
cord-350836-1enteev7	214	40	(	(	-LRB-
cord-350836-1enteev7	214	41	181	181	CD
cord-350836-1enteev7	214	42	)	)	-RRB-
cord-350836-1enteev7	214	43	,	,	,
cord-350836-1enteev7	214	44	as	as	IN
cord-350836-1enteev7	214	45	has	have	VBZ
cord-350836-1enteev7	214	46	been	be	VBN
cord-350836-1enteev7	214	47	found	find	VBN
cord-350836-1enteev7	214	48	to	to	TO
cord-350836-1enteev7	214	49	be	be	VB
cord-350836-1enteev7	214	50	the	the	DT
cord-350836-1enteev7	214	51	case	case	NN
cord-350836-1enteev7	214	52	for	for	IN
cord-350836-1enteev7	214	53	HCV	HCV	NNP
cord-350836-1enteev7	214	54	RNA	RNA	NNP
cord-350836-1enteev7	214	55	(	(	-LRB-
cord-350836-1enteev7	214	56	179	179	CD
cord-350836-1enteev7	214	57	)	)	-RRB-
cord-350836-1enteev7	214	58	.	.	.
cord-350836-1enteev7	214	59	]	]	-RRB-
cord-350836-1enteev7	215	1	It	-PRON-	PRP
cord-350836-1enteev7	215	2	appears	appear	VBZ
cord-350836-1enteev7	215	3	that	that	IN
cord-350836-1enteev7	215	4	the	the	DT
cord-350836-1enteev7	215	5	5	5	CD
cord-350836-1enteev7	215	6	′	′	CD
cord-350836-1enteev7	215	7	monophosphate	monophosphate	NN
cord-350836-1enteev7	215	8	is	be	VBZ
cord-350836-1enteev7	215	9	the	the	DT
cord-350836-1enteev7	215	10	determinate	determinate	JJ
cord-350836-1enteev7	215	11	feature	feature	NN
cord-350836-1enteev7	215	12	for	for	IN
cord-350836-1enteev7	215	13	RIG	rig	NN
cord-350836-1enteev7	215	14	-	-	:
cord-350836-1enteev7	215	15	I	-PRON-	PRP
cord-350836-1enteev7	215	16	activation	activation	VBP
cord-350836-1enteev7	215	17	independently	independently	RB
cord-350836-1enteev7	215	18	of	of	IN
cord-350836-1enteev7	215	19	the	the	DT
cord-350836-1enteev7	215	20	5	5	CD
cord-350836-1enteev7	215	21	′	′	CD
cord-350836-1enteev7	215	22	or	or	CC
cord-350836-1enteev7	215	23	3	3	CD
cord-350836-1enteev7	215	24	′	′	CD
cord-350836-1enteev7	215	25	OH	oh	UH
cord-350836-1enteev7	215	26	group	group	NN
cord-350836-1enteev7	215	27	in	in	IN
cord-350836-1enteev7	215	28	all	all	PDT
cord-350836-1enteev7	215	29	these	these	DT
cord-350836-1enteev7	215	30	cases	case	NNS
cord-350836-1enteev7	215	31	.	.	.
cord-350836-1enteev7	216	1	A	a	DT
cord-350836-1enteev7	216	2	possible	possible	JJ
cord-350836-1enteev7	216	3	explanation	explanation	NN
cord-350836-1enteev7	216	4	for	for	IN
cord-350836-1enteev7	216	5	the	the	DT
cord-350836-1enteev7	216	6	discrepancy	discrepancy	NN
cord-350836-1enteev7	216	7	between	between	IN
cord-350836-1enteev7	216	8	the	the	DT
cord-350836-1enteev7	216	9	studies	study	NNS
cord-350836-1enteev7	216	10	was	be	VBD
cord-350836-1enteev7	216	11	that	that	IN
cord-350836-1enteev7	216	12	higher	high	JJR
cord-350836-1enteev7	216	13	order	order	NN
cord-350836-1enteev7	216	14	RNA	RNA	NNP
cord-350836-1enteev7	216	15	structures	structure	NNS
cord-350836-1enteev7	216	16	might	may	MD
cord-350836-1enteev7	216	17	compensate	compensate	VB
cord-350836-1enteev7	216	18	for	for	IN
cord-350836-1enteev7	216	19	the	the	DT
cord-350836-1enteev7	216	20	less	less	RBR
cord-350836-1enteev7	216	21	optimal	optimal	JJ
cord-350836-1enteev7	216	22	5	5	CD
cord-350836-1enteev7	216	23	′	′	CD
cord-350836-1enteev7	216	24	and	and	CC
cord-350836-1enteev7	216	25	3	3	CD
cord-350836-1enteev7	216	26	′	′	CD
cord-350836-1enteev7	216	27	ends	end	NNS
cord-350836-1enteev7	216	28	,	,	,
cord-350836-1enteev7	216	29	as	as	IN
cord-350836-1enteev7	216	30	monophosphate	monophosphate	NN
cord-350836-1enteev7	216	31	dsRNA	dsRNA	NNS
cord-350836-1enteev7	216	32	that	that	WDT
cord-350836-1enteev7	216	33	did	do	VBD
cord-350836-1enteev7	216	34	not	not	RB
cord-350836-1enteev7	216	35	contain	contain	VB
cord-350836-1enteev7	216	36	stem	stem	NN
cord-350836-1enteev7	216	37	-	-	HYPH
cord-350836-1enteev7	216	38	loop	loop	NN
cord-350836-1enteev7	216	39	structures	structure	NNS
cord-350836-1enteev7	216	40	did	do	VBD
cord-350836-1enteev7	216	41	not	not	RB
cord-350836-1enteev7	216	42	activate	activate	VB
cord-350836-1enteev7	216	43	RIG	rig	NN
cord-350836-1enteev7	216	44	-	-	:
cord-350836-1enteev7	216	45	I	I	NNP
cord-350836-1enteev7	216	46	and	and	CC
cord-350836-1enteev7	216	47	RNA	RNA	NNP
cord-350836-1enteev7	216	48	regions	region	NNS
cord-350836-1enteev7	216	49	repetitive	repetitive	JJ
cord-350836-1enteev7	216	50	in	in	IN
cord-350836-1enteev7	216	51	certain	certain	JJ
cord-350836-1enteev7	216	52	nucleotides	nucleotide	NNS
cord-350836-1enteev7	216	53	had	have	VBD
cord-350836-1enteev7	216	54	been	be	VBN
cord-350836-1enteev7	216	55	found	find	VBN
cord-350836-1enteev7	216	56	to	to	TO
cord-350836-1enteev7	216	57	be	be	VB
cord-350836-1enteev7	216	58	critical	critical	JJ
cord-350836-1enteev7	216	59	for	for	IN
cord-350836-1enteev7	216	60	RIG	rig	NN
cord-350836-1enteev7	216	61	-	-	:
cord-350836-1enteev7	216	62	I	-PRON-	PRP
cord-350836-1enteev7	216	63	activation	activation	NN
cord-350836-1enteev7	216	64	(	(	-LRB-
cord-350836-1enteev7	216	65	179	179	CD
cord-350836-1enteev7	216	66	)	)	-RRB-
cord-350836-1enteev7	216	67	.	.	.
cord-350836-1enteev7	217	1	Future	future	JJ
cord-350836-1enteev7	217	2	studies	study	NNS
cord-350836-1enteev7	217	3	are	be	VBP
cord-350836-1enteev7	217	4	required	require	VBN
cord-350836-1enteev7	217	5	to	to	TO
cord-350836-1enteev7	217	6	further	further	RB
cord-350836-1enteev7	217	7	characterize	characterize	VB
cord-350836-1enteev7	217	8	the	the	DT
cord-350836-1enteev7	217	9	behavior	behavior	NN
cord-350836-1enteev7	217	10	of	of	IN
cord-350836-1enteev7	217	11	RIG	rig	NN
cord-350836-1enteev7	217	12	-	-	:
cord-350836-1enteev7	217	13	I	-PRON-	PRP
cord-350836-1enteev7	217	14	with	with	IN
cord-350836-1enteev7	217	15	these	these	DT
cord-350836-1enteev7	217	16	RNA	RNA	NNP
cord-350836-1enteev7	217	17	species	specie	NNS
cord-350836-1enteev7	217	18	.	.	.
cord-350836-1enteev7	218	1	As	as	IN
cord-350836-1enteev7	218	2	previously	previously	RB
cord-350836-1enteev7	218	3	mentioned	mention	VBN
cord-350836-1enteev7	218	4	,	,	,
cord-350836-1enteev7	218	5	MDA5	MDA5	NNP
cord-350836-1enteev7	218	6	preferentially	preferentially	RB
cord-350836-1enteev7	218	7	associates	associate	VBZ
cord-350836-1enteev7	218	8	with	with	IN
cord-350836-1enteev7	218	9	long	long	JJ
cord-350836-1enteev7	218	10	dsRNA	dsrna	NN
cord-350836-1enteev7	218	11	(	(	-LRB-
cord-350836-1enteev7	218	12	76	76	CD
cord-350836-1enteev7	218	13	)	)	-RRB-
cord-350836-1enteev7	219	1	(	(	-LRB-
cord-350836-1enteev7	219	2	77	77	CD
cord-350836-1enteev7	219	3	)	)	-RRB-
cord-350836-1enteev7	219	4	(	(	-LRB-
cord-350836-1enteev7	219	5	78	78	CD
cord-350836-1enteev7	219	6	)	)	-RRB-
cord-350836-1enteev7	219	7	(	(	-LRB-
cord-350836-1enteev7	219	8	79	79	CD
cord-350836-1enteev7	219	9	)	)	-RRB-
cord-350836-1enteev7	219	10	.	.	.
cord-350836-1enteev7	220	1	The	the	DT
cord-350836-1enteev7	220	2	crystal	crystal	NN
cord-350836-1enteev7	220	3	structure	structure	NN
cord-350836-1enteev7	220	4	and	and	CC
cord-350836-1enteev7	220	5	molecular	molecular	JJ
cord-350836-1enteev7	220	6	modeling	modeling	NN
cord-350836-1enteev7	220	7	of	of	IN
cord-350836-1enteev7	220	8	MDA5	MDA5	NNP
cord-350836-1enteev7	220	9	/	/	SYM
cord-350836-1enteev7	220	10	dsRNA	dsrna	NN
cord-350836-1enteev7	220	11	complex	complex	NN
cord-350836-1enteev7	220	12	suggest	suggest	VBP
cord-350836-1enteev7	220	13	that	that	IN
cord-350836-1enteev7	220	14	it	-PRON-	PRP
cord-350836-1enteev7	220	15	can	can	MD
cord-350836-1enteev7	220	16	recognize	recognize	VB
cord-350836-1enteev7	220	17	the	the	DT
cord-350836-1enteev7	220	18	entire	entire	JJ
cord-350836-1enteev7	220	19	first	first	JJ
cord-350836-1enteev7	220	20	turn	turn	NN
cord-350836-1enteev7	220	21	of	of	IN
cord-350836-1enteev7	220	22	the	the	DT
cord-350836-1enteev7	220	23	blunt	blunt	NN
cord-350836-1enteev7	220	24	-	-	HYPH
cord-350836-1enteev7	220	25	ended	end	VBN
cord-350836-1enteev7	220	26	dsRNA	dsrna	NN
cord-350836-1enteev7	220	27	(	(	-LRB-
cord-350836-1enteev7	220	28	182	182	CD
cord-350836-1enteev7	220	29	)	)	-RRB-
cord-350836-1enteev7	220	30	in	in	IN
cord-350836-1enteev7	220	31	a	a	DT
cord-350836-1enteev7	220	32	similar	similar	JJ
cord-350836-1enteev7	220	33	way	way	NN
cord-350836-1enteev7	220	34	as	as	IN
cord-350836-1enteev7	220	35	LGP2	LGP2	NNP
cord-350836-1enteev7	220	36	can	can	MD
cord-350836-1enteev7	220	37	(	(	-LRB-
cord-350836-1enteev7	220	38	183	183	CD
cord-350836-1enteev7	220	39	)	)	-RRB-
cord-350836-1enteev7	220	40	.	.	.
cord-350836-1enteev7	221	1	Like	like	IN
cord-350836-1enteev7	221	2	RIG	rig	NN
cord-350836-1enteev7	221	3	-	-	:
cord-350836-1enteev7	221	4	I	I	NNP
cord-350836-1enteev7	221	5	and	and	CC
cord-350836-1enteev7	221	6	MDA5	MDA5	NNP
cord-350836-1enteev7	221	7	,	,	,
cord-350836-1enteev7	221	8	LGP2	LGP2	NNP
cord-350836-1enteev7	221	9	belongs	belong	VBZ
cord-350836-1enteev7	221	10	to	to	IN
cord-350836-1enteev7	221	11	the	the	DT
cord-350836-1enteev7	221	12	ATP	ATP	NNP
cord-350836-1enteev7	221	13	-	-	HYPH
cord-350836-1enteev7	221	14	dependent	dependent	JJ
cord-350836-1enteev7	221	15	DExD	DExD	NNS
cord-350836-1enteev7	221	16	/	/	SYM
cord-350836-1enteev7	221	17	H	h	NN
cord-350836-1enteev7	221	18	box	box	NN
cord-350836-1enteev7	221	19	RNA	RNA	NNP
cord-350836-1enteev7	221	20	helicases	helicase	NNS
cord-350836-1enteev7	221	21	(	(	-LRB-
cord-350836-1enteev7	221	22	184	184	CD
cord-350836-1enteev7	221	23	)	)	-RRB-
cord-350836-1enteev7	221	24	,	,	,
cord-350836-1enteev7	221	25	which	which	WDT
cord-350836-1enteev7	221	26	is	be	VBZ
cord-350836-1enteev7	221	27	structurally	structurally	RB
cord-350836-1enteev7	221	28	similar	similar	JJ
cord-350836-1enteev7	221	29	to	to	IN
cord-350836-1enteev7	221	30	RIG	rig	NN
cord-350836-1enteev7	221	31	-	-	:
cord-350836-1enteev7	221	32	I	I	NNP
cord-350836-1enteev7	221	33	and	and	CC
cord-350836-1enteev7	221	34	MDA5	MDA5	NNP
cord-350836-1enteev7	221	35	but	but	CC
cord-350836-1enteev7	221	36	lacks	lack	VBZ
cord-350836-1enteev7	221	37	the	the	DT
cord-350836-1enteev7	221	38	CARD	card	NN
cord-350836-1enteev7	221	39	domains	domain	NNS
cord-350836-1enteev7	221	40	at	at	IN
cord-350836-1enteev7	221	41	the	the	DT
cord-350836-1enteev7	221	42	N	n	CD
cord-350836-1enteev7	221	43	terminus	terminus	NN
cord-350836-1enteev7	221	44	(	(	-LRB-
cord-350836-1enteev7	221	45	185	185	CD
cord-350836-1enteev7	221	46	)	)	-RRB-
cord-350836-1enteev7	221	47	.	.	.
cord-350836-1enteev7	222	1	MDA5	MDA5	NNP
cord-350836-1enteev7	222	2	has	have	VBZ
cord-350836-1enteev7	222	3	also	also	RB
cord-350836-1enteev7	222	4	been	be	VBN
cord-350836-1enteev7	222	5	found	find	VBN
cord-350836-1enteev7	222	6	to	to	TO
cord-350836-1enteev7	222	7	be	be	VB
cord-350836-1enteev7	222	8	activated	activate	VBN
cord-350836-1enteev7	222	9	by	by	IN
cord-350836-1enteev7	222	10	the	the	DT
cord-350836-1enteev7	222	11	digested	digest	VBN
cord-350836-1enteev7	222	12	products	product	NNS
cord-350836-1enteev7	222	13	of	of	IN
cord-350836-1enteev7	222	14	RNase	RNase	NNP
cord-350836-1enteev7	222	15	L	L	NNP
cord-350836-1enteev7	222	16	specifically	specifically	RB
cord-350836-1enteev7	222	17	from	from	IN
cord-350836-1enteev7	222	18	parainfluenza	parainfluenza	NNP
cord-350836-1enteev7	222	19	virus	virus	NNP
cord-350836-1enteev7	222	20	(	(	-LRB-
cord-350836-1enteev7	222	21	186	186	CD
cord-350836-1enteev7	222	22	)	)	-RRB-
cord-350836-1enteev7	222	23	.	.	.
cord-350836-1enteev7	223	1	The	the	DT
cord-350836-1enteev7	223	2	presence	presence	NN
cord-350836-1enteev7	223	3	of	of	IN
cord-350836-1enteev7	223	4	certain	certain	JJ
cord-350836-1enteev7	223	5	repetitive	repetitive	JJ
cord-350836-1enteev7	223	6	RNA	RNA	NNP
cord-350836-1enteev7	223	7	elements	element	NNS
cord-350836-1enteev7	223	8	appears	appear	VBZ
cord-350836-1enteev7	223	9	to	to	TO
cord-350836-1enteev7	223	10	be	be	VB
cord-350836-1enteev7	223	11	another	another	DT
cord-350836-1enteev7	223	12	contributing	contribute	VBG
cord-350836-1enteev7	223	13	factor	factor	NN
cord-350836-1enteev7	223	14	in	in	IN
cord-350836-1enteev7	223	15	determining	determine	VBG
cord-350836-1enteev7	223	16	interaction	interaction	NN
cord-350836-1enteev7	223	17	of	of	IN
cord-350836-1enteev7	223	18	RNA	RNA	NNP
cord-350836-1enteev7	223	19	with	with	IN
cord-350836-1enteev7	223	20	RIG	rig	NN
cord-350836-1enteev7	223	21	-	-	:
cord-350836-1enteev7	223	22	I	I	NNP
cord-350836-1enteev7	223	23	and	and	CC
cord-350836-1enteev7	223	24	MDA5	MDA5	NNP
cord-350836-1enteev7	223	25	,	,	,
cord-350836-1enteev7	223	26	which	which	WDT
cord-350836-1enteev7	223	27	has	have	VBZ
cord-350836-1enteev7	223	28	recently	recently	RB
cord-350836-1enteev7	223	29	been	be	VBN
cord-350836-1enteev7	223	30	described	describe	VBN
cord-350836-1enteev7	223	31	in	in	IN
cord-350836-1enteev7	223	32	detail	detail	NN
cord-350836-1enteev7	223	33	elsewhere	elsewhere	RB
cord-350836-1enteev7	223	34	(	(	-LRB-
cord-350836-1enteev7	223	35	187	187	CD
cord-350836-1enteev7	223	36	)	)	-RRB-
cord-350836-1enteev7	223	37	.	.	.
cord-350836-1enteev7	224	1	While	while	IN
cord-350836-1enteev7	224	2	RIG	rig	NN
cord-350836-1enteev7	224	3	-	-	:
cord-350836-1enteev7	224	4	I	I	NNP
cord-350836-1enteev7	224	5	and	and	CC
cord-350836-1enteev7	224	6	MDA5	MDA5	NNP
cord-350836-1enteev7	224	7	are	be	VBP
cord-350836-1enteev7	224	8	mostly	mostly	RB
cord-350836-1enteev7	224	9	implicated	implicate	VBN
cord-350836-1enteev7	224	10	in	in	IN
cord-350836-1enteev7	224	11	the	the	DT
cord-350836-1enteev7	224	12	immune	immune	JJ
cord-350836-1enteev7	224	13	response	response	NN
cord-350836-1enteev7	224	14	to	to	IN
cord-350836-1enteev7	224	15	RNA	RNA	NNP
cord-350836-1enteev7	224	16	viruses	virus	NNS
cord-350836-1enteev7	224	17	,	,	,
cord-350836-1enteev7	224	18	it	-PRON-	PRP
cord-350836-1enteev7	224	19	has	have	VBZ
cord-350836-1enteev7	224	20	also	also	RB
cord-350836-1enteev7	224	21	been	be	VBN
cord-350836-1enteev7	224	22	found	find	VBN
cord-350836-1enteev7	224	23	to	to	TO
cord-350836-1enteev7	224	24	be	be	VB
cord-350836-1enteev7	224	25	activated	activate	VBN
cord-350836-1enteev7	224	26	by	by	IN
cord-350836-1enteev7	224	27	5	5	CD
cord-350836-1enteev7	224	28	′	′	CD
cord-350836-1enteev7	224	29	tri	tri	JJ
cord-350836-1enteev7	224	30	-	-	JJ
cord-350836-1enteev7	224	31	phosphorylated	phosphorylated	JJ
cord-350836-1enteev7	224	32	dsRNA	dsrna	NN
cord-350836-1enteev7	224	33	intermediates	intermediate	NNS
cord-350836-1enteev7	224	34	generated	generate	VBN
cord-350836-1enteev7	224	35	by	by	IN
cord-350836-1enteev7	224	36	cellular	cellular	JJ
cord-350836-1enteev7	224	37	RNA	RNA	NNP
cord-350836-1enteev7	224	38	polymerase	polymerase	NN
cord-350836-1enteev7	224	39	III	III	NNP
cord-350836-1enteev7	224	40	from	from	IN
cord-350836-1enteev7	224	41	AT	at	IN
cord-350836-1enteev7	224	42	-	-	HYPH
cord-350836-1enteev7	224	43	rich	rich	JJ
cord-350836-1enteev7	224	44	DNA	dna	NN
cord-350836-1enteev7	224	45	sequences	sequence	NNS
cord-350836-1enteev7	224	46	(	(	-LRB-
cord-350836-1enteev7	224	47	188	188	CD
cord-350836-1enteev7	224	48	)	)	-RRB-
cord-350836-1enteev7	224	49	and	and	CC
cord-350836-1enteev7	224	50	during	during	IN
cord-350836-1enteev7	224	51	infection	infection	NN
cord-350836-1enteev7	224	52	with	with	IN
cord-350836-1enteev7	224	53	Epstein	Epstein	NNP
cord-350836-1enteev7	224	54	-	-	HYPH
cord-350836-1enteev7	224	55	Barr	Barr	NNP
cord-350836-1enteev7	224	56	virus	virus	NN
cord-350836-1enteev7	224	57	(	(	-LRB-
cord-350836-1enteev7	224	58	a	a	DT
cord-350836-1enteev7	224	59	DNA	dna	NN
cord-350836-1enteev7	224	60	virus	virus	NN
cord-350836-1enteev7	224	61	)	)	-RRB-
cord-350836-1enteev7	224	62	(	(	-LRB-
cord-350836-1enteev7	224	63	189	189	CD
cord-350836-1enteev7	224	64	)	)	-RRB-
cord-350836-1enteev7	224	65	.	.	.
cord-350836-1enteev7	225	1	RIG	rig	NN
cord-350836-1enteev7	225	2	-	-	:
cord-350836-1enteev7	225	3	I	-PRON-	PRP
cord-350836-1enteev7	225	4	has	have	VBZ
cord-350836-1enteev7	225	5	additional	additional	JJ
cord-350836-1enteev7	225	6	binding	binding	JJ
cord-350836-1enteev7	225	7	preferences	preference	NNS
cord-350836-1enteev7	225	8	for	for	IN
cord-350836-1enteev7	225	9	certain	certain	JJ
cord-350836-1enteev7	225	10	nucleotide	nucleotide	JJ
cord-350836-1enteev7	225	11	motifs	motif	NNS
cord-350836-1enteev7	225	12	,	,	,
cord-350836-1enteev7	225	13	such	such	JJ
cord-350836-1enteev7	225	14	as	as	IN
cord-350836-1enteev7	225	15	uridine	uridine	NN
cord-350836-1enteev7	225	16	-	-	HYPH
cord-350836-1enteev7	225	17	rich	rich	JJ
cord-350836-1enteev7	225	18	5	5	CD
cord-350836-1enteev7	225	19	′	′	CD
cord-350836-1enteev7	225	20	tri	tri	JJ
cord-350836-1enteev7	225	21	-	-	JJ
cord-350836-1enteev7	225	22	phosphorylated	phosphorylated	JJ
cord-350836-1enteev7	225	23	hairpin	hairpin	NN
cord-350836-1enteev7	225	24	RNA	RNA	NNP
cord-350836-1enteev7	225	25	(	(	-LRB-
cord-350836-1enteev7	225	26	190	190	CD
cord-350836-1enteev7	225	27	)	)	-RRB-
cord-350836-1enteev7	225	28	,	,	,
cord-350836-1enteev7	225	29	synthetic	synthetic	JJ
cord-350836-1enteev7	225	30	AU	au	JJ
cord-350836-1enteev7	225	31	-	-	HYPH
cord-350836-1enteev7	225	32	rich	rich	JJ
cord-350836-1enteev7	225	33	hairpins	hairpin	NNS
cord-350836-1enteev7	225	34	(	(	-LRB-
cord-350836-1enteev7	225	35	191	191	CD
cord-350836-1enteev7	225	36	)	)	-RRB-
cord-350836-1enteev7	225	37	and	and	CC
cord-350836-1enteev7	225	38	those	those	DT
cord-350836-1enteev7	225	39	naturally	naturally	RB
cord-350836-1enteev7	225	40	found	find	VBN
cord-350836-1enteev7	225	41	in	in	IN
cord-350836-1enteev7	225	42	the	the	DT
cord-350836-1enteev7	225	43	genomes	genome	NNS
cord-350836-1enteev7	225	44	of	of	IN
cord-350836-1enteev7	225	45	Sendai	Sendai	NNP
cord-350836-1enteev7	225	46	virus	virus	NN
cord-350836-1enteev7	225	47	defective	defective	JJ
cord-350836-1enteev7	225	48	-	-	HYPH
cord-350836-1enteev7	225	49	interfering	interfere	VBG
cord-350836-1enteev7	225	50	(	(	-LRB-
cord-350836-1enteev7	225	51	DI	DI	NNP
cord-350836-1enteev7	225	52	)	)	-RRB-
cord-350836-1enteev7	225	53	particles	particle	NNS
cord-350836-1enteev7	225	54	(	(	-LRB-
cord-350836-1enteev7	225	55	192	192	CD
cord-350836-1enteev7	225	56	)	)	-RRB-
cord-350836-1enteev7	225	57	,	,	,
cord-350836-1enteev7	225	58	measles	measle	NNS
cord-350836-1enteev7	225	59	(	(	-LRB-
cord-350836-1enteev7	225	60	193	193	CD
cord-350836-1enteev7	225	61	)	)	-RRB-
cord-350836-1enteev7	225	62	,	,	,
cord-350836-1enteev7	225	63	Influenza	Influenza	NNP
cord-350836-1enteev7	225	64	A	a	DT
cord-350836-1enteev7	225	65	virus	virus	NN
cord-350836-1enteev7	225	66	(	(	-LRB-
cord-350836-1enteev7	225	67	IAV	IAV	NNP
cord-350836-1enteev7	225	68	)	)	-RRB-
cord-350836-1enteev7	225	69	(	(	-LRB-
cord-350836-1enteev7	225	70	194	194	CD
cord-350836-1enteev7	225	71	)	)	-RRB-
cord-350836-1enteev7	225	72	and	and	CC
cord-350836-1enteev7	225	73	in	in	IN
cord-350836-1enteev7	225	74	KSHV	KSHV	NNP
cord-350836-1enteev7	225	75	RNA	RNA	NNP
cord-350836-1enteev7	225	76	transcripts	transcript	NNS
cord-350836-1enteev7	225	77	(	(	-LRB-
cord-350836-1enteev7	225	78	195	195	CD
cord-350836-1enteev7	225	79	)	)	-RRB-
cord-350836-1enteev7	225	80	,	,	,
cord-350836-1enteev7	225	81	and	and	CC
cord-350836-1enteev7	225	82	poly	poly	JJ
cord-350836-1enteev7	225	83	(	(	-LRB-
cord-350836-1enteev7	225	84	U	U	NNP
cord-350836-1enteev7	225	85	/	/	SYM
cord-350836-1enteev7	225	86	UC	UC	NNP
cord-350836-1enteev7	225	87	)	)	-RRB-
cord-350836-1enteev7	225	88	regions	region	NNS
cord-350836-1enteev7	225	89	(	(	-LRB-
cord-350836-1enteev7	225	90	196	196	CD
cord-350836-1enteev7	225	91	)	)	-RRB-
cord-350836-1enteev7	225	92	and	and	CC
cord-350836-1enteev7	225	93	poly	poly	NNP
cord-350836-1enteev7	225	94	(	(	-LRB-
cord-350836-1enteev7	225	95	A	A	NNP
cord-350836-1enteev7	225	96	/	/	SYM
cord-350836-1enteev7	225	97	AG	AG	NNP
cord-350836-1enteev7	225	98	)	)	-RRB-
cord-350836-1enteev7	225	99	regions	region	NNS
cord-350836-1enteev7	225	100	(	(	-LRB-
cord-350836-1enteev7	225	101	197	197	CD
cord-350836-1enteev7	225	102	)	)	-RRB-
cord-350836-1enteev7	225	103	in	in	IN
cord-350836-1enteev7	225	104	the	the	DT
cord-350836-1enteev7	225	105	antisense	antisense	NN
cord-350836-1enteev7	225	106	Hepatitis	Hepatitis	NNP
cord-350836-1enteev7	225	107	C	C	NNP
cord-350836-1enteev7	225	108	virus	virus	NN
cord-350836-1enteev7	225	109	(	(	-LRB-
cord-350836-1enteev7	225	110	HCV	HCV	NNP
cord-350836-1enteev7	225	111	)	)	-RRB-
cord-350836-1enteev7	225	112	genome	genome	NN
cord-350836-1enteev7	225	113	.	.	.
cord-350836-1enteev7	226	1	It	-PRON-	PRP
cord-350836-1enteev7	226	2	is	be	VBZ
cord-350836-1enteev7	226	3	of	of	IN
cord-350836-1enteev7	226	4	particular	particular	JJ
cord-350836-1enteev7	226	5	interest	interest	NN
cord-350836-1enteev7	226	6	that	that	WDT
cord-350836-1enteev7	226	7	the	the	DT
cord-350836-1enteev7	226	8	poly	poly	NNP
cord-350836-1enteev7	226	9	(	(	-LRB-
cord-350836-1enteev7	226	10	A	A	NNP
cord-350836-1enteev7	226	11	/	/	SYM
cord-350836-1enteev7	226	12	AG	AG	NNP
cord-350836-1enteev7	226	13	)	)	-RRB-
cord-350836-1enteev7	226	14	HCV	HCV	NNP
cord-350836-1enteev7	226	15	regions	region	NNS
cord-350836-1enteev7	226	16	are	be	VBP
cord-350836-1enteev7	226	17	located	locate	VBN
cord-350836-1enteev7	226	18	significantly	significantly	RB
cord-350836-1enteev7	226	19	downstream	downstream	RB
cord-350836-1enteev7	226	20	of	of	IN
cord-350836-1enteev7	226	21	the	the	DT
cord-350836-1enteev7	226	22	5	5	CD
cord-350836-1enteev7	226	23	′	′	CD
cord-350836-1enteev7	226	24	triphosphate	triphosphate	NN
cord-350836-1enteev7	226	25	group	group	NN
cord-350836-1enteev7	226	26	(	(	-LRB-
cord-350836-1enteev7	226	27	197	197	CD
cord-350836-1enteev7	226	28	)	)	-RRB-
cord-350836-1enteev7	226	29	,	,	,
cord-350836-1enteev7	226	30	thus	thus	RB
cord-350836-1enteev7	226	31	potentially	potentially	RB
cord-350836-1enteev7	226	32	implicating	implicate	VBG
cord-350836-1enteev7	226	33	other	other	JJ
cord-350836-1enteev7	226	34	parts	part	NNS
cord-350836-1enteev7	226	35	of	of	IN
cord-350836-1enteev7	226	36	RIG	rig	NN
cord-350836-1enteev7	226	37	-	-	:
cord-350836-1enteev7	226	38	I	i	NN
cord-350836-1enteev7	226	39	(	(	-LRB-
cord-350836-1enteev7	226	40	e.g.	e.g.	RB
cord-350836-1enteev7	226	41	,	,	,
cord-350836-1enteev7	226	42	helicase	helicase	NN
cord-350836-1enteev7	226	43	domain	domain	NN
cord-350836-1enteev7	226	44	)	)	-RRB-
cord-350836-1enteev7	226	45	as	as	IN
cord-350836-1enteev7	226	46	potential	potential	JJ
cord-350836-1enteev7	226	47	RNA	RNA	NNP
cord-350836-1enteev7	226	48	interacting	interact	VBG
cord-350836-1enteev7	226	49	domains	domain	NNS
cord-350836-1enteev7	226	50	.	.	.
cord-350836-1enteev7	227	1	Repetitive	Repetitive	NNP
cord-350836-1enteev7	227	2	RNA	RNA	NNP
cord-350836-1enteev7	227	3	elements	element	NNS
cord-350836-1enteev7	227	4	may	may	MD
cord-350836-1enteev7	227	5	also	also	RB
cord-350836-1enteev7	227	6	be	be	VB
cord-350836-1enteev7	227	7	important	important	JJ
cord-350836-1enteev7	227	8	in	in	IN
cord-350836-1enteev7	227	9	allowing	allow	VBG
cord-350836-1enteev7	227	10	for	for	IN
cord-350836-1enteev7	227	11	interaction	interaction	NN
cord-350836-1enteev7	227	12	of	of	IN
cord-350836-1enteev7	227	13	inhibitory	inhibitory	JJ
cord-350836-1enteev7	227	14	RNAs	rna	NNS
cord-350836-1enteev7	227	15	that	that	WDT
cord-350836-1enteev7	227	16	do	do	VBP
cord-350836-1enteev7	227	17	not	not	RB
cord-350836-1enteev7	227	18	have	have	VB
cord-350836-1enteev7	227	19	5	5	CD
cord-350836-1enteev7	227	20	′	′	CD
cord-350836-1enteev7	227	21	or	or	CC
cord-350836-1enteev7	227	22	3	3	CD
cord-350836-1enteev7	227	23	′	′	CD
cord-350836-1enteev7	227	24	features	feature	NNS
cord-350836-1enteev7	227	25	needed	need	VBN
cord-350836-1enteev7	227	26	for	for	IN
cord-350836-1enteev7	227	27	full	full	JJ
cord-350836-1enteev7	227	28	activation	activation	NN
cord-350836-1enteev7	227	29	of	of	IN
cord-350836-1enteev7	227	30	RIG	rig	NN
cord-350836-1enteev7	227	31	-	-	:
cord-350836-1enteev7	227	32	I	-PRON-	PRP
cord-350836-1enteev7	227	33	,	,	,
cord-350836-1enteev7	227	34	as	as	IN
cord-350836-1enteev7	227	35	has	have	VBZ
cord-350836-1enteev7	227	36	been	be	VBN
cord-350836-1enteev7	227	37	shown	show	VBN
cord-350836-1enteev7	227	38	to	to	TO
cord-350836-1enteev7	227	39	be	be	VB
cord-350836-1enteev7	227	40	the	the	DT
cord-350836-1enteev7	227	41	case	case	NN
cord-350836-1enteev7	227	42	with	with	IN
cord-350836-1enteev7	227	43	GA	GA	NNP
cord-350836-1enteev7	227	44	-	-	HYPH
cord-350836-1enteev7	227	45	rich	rich	JJ
cord-350836-1enteev7	227	46	regions	region	NNS
cord-350836-1enteev7	227	47	in	in	IN
cord-350836-1enteev7	227	48	circular	circular	JJ
cord-350836-1enteev7	227	49	longnon	longnon	NN
cord-350836-1enteev7	227	50	-	-	HYPH
cord-350836-1enteev7	227	51	coding	code	VBG
cord-350836-1enteev7	227	52	RNA	RNA	NNP
cord-350836-1enteev7	227	53	lnc	lnc	NNP
cord-350836-1enteev7	227	54	-	-	HYPH
cord-350836-1enteev7	227	55	Lsm3b	Lsm3b	NNP
cord-350836-1enteev7	227	56	(	(	-LRB-
cord-350836-1enteev7	227	57	198	198	CD
cord-350836-1enteev7	227	58	)	)	-RRB-
cord-350836-1enteev7	227	59	.	.	.
cord-350836-1enteev7	228	1	These	these	DT
cord-350836-1enteev7	228	2	specific	specific	JJ
cord-350836-1enteev7	228	3	interactions	interaction	NNS
cord-350836-1enteev7	228	4	explain	explain	VBP
cord-350836-1enteev7	228	5	their	-PRON-	PRP$
cord-350836-1enteev7	228	6	primary	primary	JJ
cord-350836-1enteev7	228	7	role	role	NN
cord-350836-1enteev7	228	8	as	as	IN
cord-350836-1enteev7	228	9	anti	anti	JJ
cord-350836-1enteev7	228	10	-	-	JJ
cord-350836-1enteev7	228	11	viral	viral	JJ
cord-350836-1enteev7	228	12	receptors	receptor	NNS
cord-350836-1enteev7	228	13	,	,	,
cord-350836-1enteev7	228	14	as	as	IN
cord-350836-1enteev7	228	15	these	these	DT
cord-350836-1enteev7	228	16	viral	viral	JJ
cord-350836-1enteev7	228	17	motifs	motif	NNS
cord-350836-1enteev7	228	18	are	be	VBP
cord-350836-1enteev7	228	19	mostly	mostly	RB
cord-350836-1enteev7	228	20	not	not	RB
cord-350836-1enteev7	228	21	found	find	VBN
cord-350836-1enteev7	228	22	in	in	IN
cord-350836-1enteev7	228	23	cellular	cellular	JJ
cord-350836-1enteev7	228	24	RNAs	rna	NNS
cord-350836-1enteev7	228	25	(	(	-LRB-
cord-350836-1enteev7	228	26	199	199	CD
cord-350836-1enteev7	228	27	)	)	-RRB-
cord-350836-1enteev7	228	28	.	.	.
cord-350836-1enteev7	229	1	RIG	rig	NN
cord-350836-1enteev7	229	2	-	-	:
cord-350836-1enteev7	229	3	I	I	NNP
cord-350836-1enteev7	229	4	and	and	CC
cord-350836-1enteev7	229	5	MDA5	MDA5	NNP
cord-350836-1enteev7	229	6	have	have	VBP
cord-350836-1enteev7	229	7	been	be	VBN
cord-350836-1enteev7	229	8	particularly	particularly	RB
cord-350836-1enteev7	229	9	implicated	implicate	VBN
cord-350836-1enteev7	229	10	in	in	IN
cord-350836-1enteev7	229	11	their	-PRON-	PRP$
cord-350836-1enteev7	229	12	response	response	NN
cord-350836-1enteev7	229	13	to	to	IN
cord-350836-1enteev7	229	14	RNA	RNA	NNP
cord-350836-1enteev7	229	15	genomes	genome	NNS
cord-350836-1enteev7	229	16	of	of	IN
cord-350836-1enteev7	229	17	viral	viral	JJ
cord-350836-1enteev7	229	18	defective	defective	JJ
cord-350836-1enteev7	229	19	interfering	interfere	VBG
cord-350836-1enteev7	229	20	(	(	-LRB-
cord-350836-1enteev7	229	21	DI	DI	NNP
cord-350836-1enteev7	229	22	)	)	-RRB-
cord-350836-1enteev7	229	23	particles	particle	NNS
cord-350836-1enteev7	229	24	,	,	,
cord-350836-1enteev7	229	25	as	as	IN
cord-350836-1enteev7	229	26	these	these	DT
cord-350836-1enteev7	229	27	defective	defective	JJ
cord-350836-1enteev7	229	28	viral	viral	JJ
cord-350836-1enteev7	229	29	genomes	genome	NNS
cord-350836-1enteev7	229	30	(	(	-LRB-
cord-350836-1enteev7	229	31	DVGs	dvg	NNS
cord-350836-1enteev7	229	32	)	)	-RRB-
cord-350836-1enteev7	229	33	have	have	VBP
cord-350836-1enteev7	229	34	originally	originally	RB
cord-350836-1enteev7	229	35	been	be	VBN
cord-350836-1enteev7	229	36	found	find	VBN
cord-350836-1enteev7	229	37	to	to	TO
cord-350836-1enteev7	229	38	induce	induce	VB
cord-350836-1enteev7	229	39	interferon	interferon	NN
cord-350836-1enteev7	229	40	signaling	signal	VBG
cord-350836-1enteev7	229	41	(	(	-LRB-
cord-350836-1enteev7	229	42	150	150	CD
cord-350836-1enteev7	229	43	)	)	-RRB-
cord-350836-1enteev7	229	44	.	.	.
cord-350836-1enteev7	230	1	DI	DI	NNP
cord-350836-1enteev7	230	2	particles	particle	NNS
cord-350836-1enteev7	230	3	are	be	VBP
cord-350836-1enteev7	230	4	produced	produce	VBN
cord-350836-1enteev7	230	5	by	by	IN
cord-350836-1enteev7	230	6	many	many	JJ
cord-350836-1enteev7	230	7	viruses	virus	NNS
cord-350836-1enteev7	230	8	during	during	IN
cord-350836-1enteev7	230	9	infection	infection	NN
cord-350836-1enteev7	230	10	,	,	,
cord-350836-1enteev7	230	11	and	and	CC
cord-350836-1enteev7	230	12	while	while	IN
cord-350836-1enteev7	230	13	they	-PRON-	PRP
cord-350836-1enteev7	230	14	are	be	VBP
cord-350836-1enteev7	230	15	similar	similar	JJ
cord-350836-1enteev7	230	16	in	in	IN
cord-350836-1enteev7	230	17	many	many	JJ
cord-350836-1enteev7	230	18	regards	regard	NNS
cord-350836-1enteev7	230	19	to	to	IN
cord-350836-1enteev7	230	20	standard	standard	JJ
cord-350836-1enteev7	230	21	viral	viral	JJ
cord-350836-1enteev7	230	22	particles	particle	NNS
cord-350836-1enteev7	230	23	,	,	,
cord-350836-1enteev7	230	24	such	such	JJ
cord-350836-1enteev7	230	25	as	as	IN
cord-350836-1enteev7	230	26	in	in	IN
cord-350836-1enteev7	230	27	appearance	appearance	NN
cord-350836-1enteev7	230	28	and	and	CC
cord-350836-1enteev7	230	29	composition	composition	NN
cord-350836-1enteev7	230	30	,	,	,
cord-350836-1enteev7	230	31	they	-PRON-	PRP
cord-350836-1enteev7	230	32	can	can	MD
cord-350836-1enteev7	230	33	not	not	RB
cord-350836-1enteev7	230	34	productively	productively	RB
cord-350836-1enteev7	230	35	infect	infect	VB
cord-350836-1enteev7	230	36	cells	cell	NNS
cord-350836-1enteev7	230	37	(	(	-LRB-
cord-350836-1enteev7	230	38	200	200	CD
cord-350836-1enteev7	230	39	)	)	-RRB-
cord-350836-1enteev7	230	40	.	.	.
cord-350836-1enteev7	231	1	This	this	DT
cord-350836-1enteev7	231	2	is	be	VBZ
cord-350836-1enteev7	231	3	largely	largely	RB
cord-350836-1enteev7	231	4	thought	think	VBN
cord-350836-1enteev7	231	5	to	to	TO
cord-350836-1enteev7	231	6	be	be	VB
cord-350836-1enteev7	231	7	due	due	JJ
cord-350836-1enteev7	231	8	to	to	IN
cord-350836-1enteev7	231	9	the	the	DT
cord-350836-1enteev7	231	10	presence	presence	NN
cord-350836-1enteev7	231	11	of	of	IN
cord-350836-1enteev7	231	12	large	large	JJ
cord-350836-1enteev7	231	13	and	and	CC
cord-350836-1enteev7	231	14	deleterious	deleterious	JJ
cord-350836-1enteev7	231	15	deletions	deletion	NNS
cord-350836-1enteev7	231	16	in	in	IN
cord-350836-1enteev7	231	17	the	the	DT
cord-350836-1enteev7	231	18	DVG	DVG	NNP
cord-350836-1enteev7	231	19	of	of	IN
cord-350836-1enteev7	231	20	DI	DI	NNP
cord-350836-1enteev7	231	21	particles	particle	NNS
cord-350836-1enteev7	231	22	(	(	-LRB-
cord-350836-1enteev7	231	23	201	201	CD
cord-350836-1enteev7	231	24	)	)	-RRB-
cord-350836-1enteev7	231	25	.	.	.
cord-350836-1enteev7	232	1	Some	some	DT
cord-350836-1enteev7	232	2	DVG	DVG	NNP
cord-350836-1enteev7	232	3	RNAs	rna	NNS
cord-350836-1enteev7	232	4	have	have	VBP
cord-350836-1enteev7	232	5	also	also	RB
cord-350836-1enteev7	232	6	been	be	VBN
cord-350836-1enteev7	232	7	noted	note	VBN
cord-350836-1enteev7	232	8	to	to	TO
cord-350836-1enteev7	232	9	have	have	VB
cord-350836-1enteev7	232	10	"	"	``
cord-350836-1enteev7	232	11	copy	copy	VB
cord-350836-1enteev7	232	12	-	-	HYPH
cord-350836-1enteev7	232	13	back	back	NN
cord-350836-1enteev7	232	14	"	"	''
cord-350836-1enteev7	232	15	motifs	motif	NNS
cord-350836-1enteev7	232	16	in	in	IN
cord-350836-1enteev7	232	17	which	which	WDT
cord-350836-1enteev7	232	18	one	one	CD
cord-350836-1enteev7	232	19	end	end	NN
cord-350836-1enteev7	232	20	of	of	IN
cord-350836-1enteev7	232	21	the	the	DT
cord-350836-1enteev7	232	22	genome	genome	NN
cord-350836-1enteev7	232	23	can	can	MD
cord-350836-1enteev7	232	24	base	base	NN
cord-350836-1enteev7	232	25	pair	pair	VB
cord-350836-1enteev7	232	26	with	with	IN
cord-350836-1enteev7	232	27	an	an	DT
cord-350836-1enteev7	232	28	inverted	inverted	JJ
cord-350836-1enteev7	232	29	copy	copy	NN
cord-350836-1enteev7	232	30	at	at	IN
cord-350836-1enteev7	232	31	the	the	DT
cord-350836-1enteev7	232	32	opposite	opposite	JJ
cord-350836-1enteev7	232	33	end	end	NN
cord-350836-1enteev7	232	34	of	of	IN
cord-350836-1enteev7	232	35	the	the	DT
cord-350836-1enteev7	232	36	genome	genome	NN
cord-350836-1enteev7	232	37	,	,	,
cord-350836-1enteev7	232	38	which	which	WDT
cord-350836-1enteev7	232	39	may	may	MD
cord-350836-1enteev7	232	40	be	be	VB
cord-350836-1enteev7	232	41	due	due	JJ
cord-350836-1enteev7	232	42	to	to	IN
cord-350836-1enteev7	232	43	stalled	stall	VBN
cord-350836-1enteev7	232	44	and	and	CC
cord-350836-1enteev7	232	45	aberrant	aberrant	JJ
cord-350836-1enteev7	232	46	replication	replication	NN
cord-350836-1enteev7	232	47	(	(	-LRB-
cord-350836-1enteev7	232	48	202	202	CD
cord-350836-1enteev7	232	49	,	,	,
cord-350836-1enteev7	232	50	203	203	CD
cord-350836-1enteev7	232	51	)	)	-RRB-
cord-350836-1enteev7	232	52	.	.	.
cord-350836-1enteev7	233	1	Copy	copy	NN
cord-350836-1enteev7	233	2	-	-	HYPH
cord-350836-1enteev7	233	3	back	back	NN
cord-350836-1enteev7	233	4	RNA	RNA	NNP
cord-350836-1enteev7	233	5	motifs	motif	NNS
cord-350836-1enteev7	233	6	specifically	specifically	RB
cord-350836-1enteev7	233	7	seem	seem	VBP
cord-350836-1enteev7	233	8	to	to	TO
cord-350836-1enteev7	233	9	be	be	VB
cord-350836-1enteev7	233	10	important	important	JJ
cord-350836-1enteev7	233	11	for	for	IN
cord-350836-1enteev7	233	12	RLR	RLR	NNP
cord-350836-1enteev7	233	13	activation	activation	NN
cord-350836-1enteev7	233	14	in	in	IN
cord-350836-1enteev7	233	15	that	that	IN
cord-350836-1enteev7	233	16	they	-PRON-	PRP
cord-350836-1enteev7	233	17	tend	tend	VBP
cord-350836-1enteev7	233	18	to	to	TO
cord-350836-1enteev7	233	19	contain	contain	VB
cord-350836-1enteev7	233	20	hairpin	hairpin	JJ
cord-350836-1enteev7	233	21	motifs	motif	NNS
cord-350836-1enteev7	233	22	and	and	CC
cord-350836-1enteev7	233	23	5	5	CD
cord-350836-1enteev7	233	24	′	′	CD
cord-350836-1enteev7	233	25	tri	tri	JJ
cord-350836-1enteev7	233	26	-	-	JJ
cord-350836-1enteev7	233	27	phosphate	phosphate	JJ
cord-350836-1enteev7	233	28	groups	group	NNS
cord-350836-1enteev7	233	29	,	,	,
cord-350836-1enteev7	233	30	as	as	IN
cord-350836-1enteev7	233	31	has	have	VBZ
cord-350836-1enteev7	233	32	been	be	VBN
cord-350836-1enteev7	233	33	found	find	VBN
cord-350836-1enteev7	233	34	for	for	IN
cord-350836-1enteev7	233	35	Sendai	Sendai	NNP
cord-350836-1enteev7	233	36	(	(	-LRB-
cord-350836-1enteev7	233	37	204	204	CD
cord-350836-1enteev7	233	38	)	)	-RRB-
cord-350836-1enteev7	233	39	(	(	-LRB-
cord-350836-1enteev7	233	40	205	205	CD
cord-350836-1enteev7	233	41	)	)	-RRB-
cord-350836-1enteev7	233	42	(	(	-LRB-
cord-350836-1enteev7	233	43	206	206	CD
cord-350836-1enteev7	233	44	)	)	-RRB-
cord-350836-1enteev7	233	45	,	,	,
cord-350836-1enteev7	233	46	measles	measle	NNS
cord-350836-1enteev7	233	47	(	(	-LRB-
cord-350836-1enteev7	233	48	35	35	CD
cord-350836-1enteev7	233	49	,	,	,
cord-350836-1enteev7	233	50	207	207	CD
cord-350836-1enteev7	233	51	)	)	-RRB-
cord-350836-1enteev7	233	52	,	,	,
cord-350836-1enteev7	233	53	and	and	CC
cord-350836-1enteev7	233	54	chikungunya	chikungunya	NN
cord-350836-1enteev7	233	55	(	(	-LRB-
cord-350836-1enteev7	233	56	35	35	CD
cord-350836-1enteev7	233	57	)	)	-RRB-
cord-350836-1enteev7	233	58	DVG	DVG	NNP
cord-350836-1enteev7	233	59	RNAs	rna	NNS
cord-350836-1enteev7	233	60	in	in	IN
cord-350836-1enteev7	233	61	activating	activate	VBG
cord-350836-1enteev7	233	62	RIG	rig	NN
cord-350836-1enteev7	233	63	-	-	HYPH
cord-350836-1enteev7	233	64	I.	i.	NN
cord-350836-1enteev7	234	1	In	in	IN
cord-350836-1enteev7	234	2	the	the	DT
cord-350836-1enteev7	234	3	case	case	NN
cord-350836-1enteev7	234	4	of	of	IN
cord-350836-1enteev7	234	5	IAV	IAV	NNP
cord-350836-1enteev7	234	6	,	,	,
cord-350836-1enteev7	234	7	DVG	DVG	NNP
cord-350836-1enteev7	234	8	RNAs	rna	NNS
cord-350836-1enteev7	234	9	might	may	MD
cord-350836-1enteev7	234	10	even	even	RB
cord-350836-1enteev7	234	11	be	be	VB
cord-350836-1enteev7	234	12	more	more	RBR
cord-350836-1enteev7	234	13	potent	potent	JJ
cord-350836-1enteev7	234	14	activators	activator	NNS
cord-350836-1enteev7	234	15	of	of	IN
cord-350836-1enteev7	234	16	RIG	rig	NN
cord-350836-1enteev7	234	17	-	-	:
cord-350836-1enteev7	234	18	I	i	NN
cord-350836-1enteev7	234	19	than	than	IN
cord-350836-1enteev7	234	20	the	the	DT
cord-350836-1enteev7	234	21	full	full	JJ
cord-350836-1enteev7	234	22	-	-	HYPH
cord-350836-1enteev7	234	23	length	length	NN
cord-350836-1enteev7	234	24	viral	viral	JJ
cord-350836-1enteev7	234	25	genome	genome	NN
cord-350836-1enteev7	234	26	.	.	.
cord-350836-1enteev7	235	1	Cells	cell	NNS
cord-350836-1enteev7	235	2	that	that	WDT
cord-350836-1enteev7	235	3	were	be	VBD
cord-350836-1enteev7	235	4	blocked	block	VBN
cord-350836-1enteev7	235	5	from	from	IN
cord-350836-1enteev7	235	6	viral	viral	JJ
cord-350836-1enteev7	235	7	protein	protein	NN
cord-350836-1enteev7	235	8	synthesis	synthesis	NN
cord-350836-1enteev7	235	9	experienced	experience	VBD
cord-350836-1enteev7	235	10	RIG	rig	NN
cord-350836-1enteev7	236	1	-I	-i	WDT
cord-350836-1enteev7	236	2	mediated	mediate	VBD
cord-350836-1enteev7	236	3	IFN1	IFN1	NNP
cord-350836-1enteev7	236	4	expression	expression	NN
cord-350836-1enteev7	236	5	when	when	WRB
cord-350836-1enteev7	236	6	infected	infect	VBN
cord-350836-1enteev7	236	7	with	with	IN
cord-350836-1enteev7	236	8	IAV	IAV	NNP
cord-350836-1enteev7	236	9	stocks	stock	NNS
cord-350836-1enteev7	236	10	grown	grow	VBN
cord-350836-1enteev7	236	11	in	in	IN
cord-350836-1enteev7	236	12	chicken	chicken	NN
cord-350836-1enteev7	236	13	embryonic	embryonic	JJ
cord-350836-1enteev7	236	14	eggs	egg	NNS
cord-350836-1enteev7	236	15	(	(	-LRB-
cord-350836-1enteev7	236	16	which	which	WDT
cord-350836-1enteev7	236	17	produced	produce	VBD
cord-350836-1enteev7	236	18	higher	high	JJR
cord-350836-1enteev7	236	19	relative	relative	JJ
cord-350836-1enteev7	236	20	quantities	quantity	NNS
cord-350836-1enteev7	236	21	of	of	IN
cord-350836-1enteev7	236	22	DI	DI	NNP
cord-350836-1enteev7	236	23	particles	particle	NNS
cord-350836-1enteev7	236	24	with	with	IN
cord-350836-1enteev7	236	25	DVG	DVG	NNP
cord-350836-1enteev7	236	26	RNAs	rna	NNS
cord-350836-1enteev7	236	27	)	)	-RRB-
cord-350836-1enteev7	236	28	but	but	CC
cord-350836-1enteev7	236	29	not	not	RB
cord-350836-1enteev7	236	30	with	with	IN
cord-350836-1enteev7	236	31	IAV	IAV	NNP
cord-350836-1enteev7	236	32	grown	grow	VBN
cord-350836-1enteev7	236	33	in	in	IN
cord-350836-1enteev7	236	34	cell	cell	NN
cord-350836-1enteev7	236	35	culture	culture	NN
cord-350836-1enteev7	236	36	,	,	,
cord-350836-1enteev7	236	37	indicating	indicate	VBG
cord-350836-1enteev7	236	38	that	that	IN
cord-350836-1enteev7	236	39	RIG	rig	NN
cord-350836-1enteev7	236	40	-	-	:
cord-350836-1enteev7	236	41	I	-PRON-	PRP
cord-350836-1enteev7	236	42	activation	activation	NN
cord-350836-1enteev7	236	43	by	by	IN
cord-350836-1enteev7	236	44	the	the	DT
cord-350836-1enteev7	236	45	genomes	genome	NNS
cord-350836-1enteev7	236	46	from	from	IN
cord-350836-1enteev7	236	47	primarily	primarily	RB
cord-350836-1enteev7	236	48	non	non	JJ
cord-350836-1enteev7	236	49	-	-	JJ
cord-350836-1enteev7	236	50	DI	di	JJ
cord-350836-1enteev7	236	51	IAV	IAV	NNP
cord-350836-1enteev7	236	52	particles	particle	NNS
cord-350836-1enteev7	236	53	may	may	MD
cord-350836-1enteev7	236	54	require	require	VB
cord-350836-1enteev7	236	55	active	active	JJ
cord-350836-1enteev7	236	56	viral	viral	JJ
cord-350836-1enteev7	236	57	RNA	RNA	NNP
cord-350836-1enteev7	236	58	synthesis	synthesis	NN
cord-350836-1enteev7	236	59	(	(	-LRB-
cord-350836-1enteev7	236	60	208	208	CD
cord-350836-1enteev7	236	61	)	)	-RRB-
cord-350836-1enteev7	236	62	.	.	.
cord-350836-1enteev7	237	1	A	a	DT
cord-350836-1enteev7	237	2	potential	potential	JJ
cord-350836-1enteev7	237	3	explanation	explanation	NN
cord-350836-1enteev7	237	4	to	to	IN
cord-350836-1enteev7	237	5	this	this	DT
cord-350836-1enteev7	237	6	observation	observation	NN
cord-350836-1enteev7	237	7	is	be	VBZ
cord-350836-1enteev7	237	8	that	that	DT
cord-350836-1enteev7	237	9	RIG	rig	NN
cord-350836-1enteev7	238	1	-I	-I	NNP
cord-350836-1enteev7	238	2	appears	appear	VBZ
cord-350836-1enteev7	238	3	to	to	TO
cord-350836-1enteev7	238	4	be	be	VB
cord-350836-1enteev7	238	5	activated	activate	VBN
cord-350836-1enteev7	238	6	by	by	IN
cord-350836-1enteev7	238	7	the	the	DT
cord-350836-1enteev7	238	8	full	full	JJ
cord-350836-1enteev7	238	9	viral	viral	JJ
cord-350836-1enteev7	238	10	genome	genome	NN
cord-350836-1enteev7	238	11	via	via	IN
cord-350836-1enteev7	238	12	its	-PRON-	PRP$
cord-350836-1enteev7	238	13	panhandle	panhandle	NN
cord-350836-1enteev7	238	14	structure	structure	NN
cord-350836-1enteev7	238	15	,	,	,
cord-350836-1enteev7	238	16	the	the	DT
cord-350836-1enteev7	238	17	affinity	affinity	NN
cord-350836-1enteev7	238	18	of	of	IN
cord-350836-1enteev7	238	19	which	which	WDT
cord-350836-1enteev7	238	20	is	be	VBZ
cord-350836-1enteev7	238	21	lowered	lower	VBN
cord-350836-1enteev7	238	22	by	by	IN
cord-350836-1enteev7	238	23	the	the	DT
cord-350836-1enteev7	238	24	presence	presence	NN
cord-350836-1enteev7	238	25	of	of	IN
cord-350836-1enteev7	238	26	mismatched	mismatched	JJ
cord-350836-1enteev7	238	27	and	and	CC
cord-350836-1enteev7	238	28	unpaired	unpaired	JJ
cord-350836-1enteev7	238	29	nucleotides	nucleotide	NNS
cord-350836-1enteev7	238	30	in	in	IN
cord-350836-1enteev7	238	31	this	this	DT
cord-350836-1enteev7	238	32	region	region	NN
cord-350836-1enteev7	238	33	of	of	IN
cord-350836-1enteev7	238	34	the	the	DT
cord-350836-1enteev7	238	35	viral	viral	JJ
cord-350836-1enteev7	238	36	genome	genome	NN
cord-350836-1enteev7	238	37	that	that	WDT
cord-350836-1enteev7	238	38	is	be	VBZ
cord-350836-1enteev7	238	39	conserved	conserve	VBN
cord-350836-1enteev7	238	40	across	across	IN
cord-350836-1enteev7	238	41	influenza	influenza	NN
cord-350836-1enteev7	238	42	virus	virus	NN
cord-350836-1enteev7	238	43	strains	strain	NNS
cord-350836-1enteev7	238	44	(	(	-LRB-
cord-350836-1enteev7	238	45	209	209	CD
cord-350836-1enteev7	238	46	)	)	-RRB-
cord-350836-1enteev7	238	47	.	.	.
cord-350836-1enteev7	239	1	However	however	RB
cord-350836-1enteev7	239	2	,	,	,
cord-350836-1enteev7	239	3	the	the	DT
cord-350836-1enteev7	239	4	overall	overall	JJ
cord-350836-1enteev7	239	5	panhandle	panhandle	JJ
cord-350836-1enteev7	239	6	structure	structure	NN
cord-350836-1enteev7	239	7	is	be	VBZ
cord-350836-1enteev7	239	8	conserved	conserve	VBN
cord-350836-1enteev7	239	9	between	between	IN
cord-350836-1enteev7	239	10	DVGs	dvg	NNS
cord-350836-1enteev7	239	11	(	(	-LRB-
cord-350836-1enteev7	239	12	205	205	CD
cord-350836-1enteev7	239	13	)	)	-RRB-
cord-350836-1enteev7	239	14	and	and	CC
cord-350836-1enteev7	239	15	the	the	DT
cord-350836-1enteev7	239	16	full	full	JJ
cord-350836-1enteev7	239	17	length	length	NN
cord-350836-1enteev7	239	18	viral	viral	JJ
cord-350836-1enteev7	239	19	genome	genome	NN
cord-350836-1enteev7	239	20	(	(	-LRB-
cord-350836-1enteev7	239	21	209	209	CD
cord-350836-1enteev7	239	22	)	)	-RRB-
cord-350836-1enteev7	239	23	,	,	,
cord-350836-1enteev7	239	24	and	and	CC
cord-350836-1enteev7	239	25	deletions	deletion	NNS
cord-350836-1enteev7	239	26	within	within	IN
cord-350836-1enteev7	239	27	DVGs	dvg	NNS
cord-350836-1enteev7	239	28	are	be	VBP
cord-350836-1enteev7	239	29	monogenic	monogenic	JJ
cord-350836-1enteev7	239	30	and	and	CC
cord-350836-1enteev7	239	31	internal	internal	JJ
cord-350836-1enteev7	239	32	(	(	-LRB-
cord-350836-1enteev7	239	33	210	210	CD
cord-350836-1enteev7	239	34	)	)	-RRB-
cord-350836-1enteev7	239	35	.	.	.
cord-350836-1enteev7	240	1	The	the	DT
cord-350836-1enteev7	240	2	specific	specific	JJ
cord-350836-1enteev7	240	3	molecular	molecular	JJ
cord-350836-1enteev7	240	4	mechanisms	mechanism	NNS
cord-350836-1enteev7	240	5	of	of	IN
cord-350836-1enteev7	240	6	enhanced	enhance	VBN
cord-350836-1enteev7	240	7	RIG	rig	NN
cord-350836-1enteev7	240	8	-	-	:
cord-350836-1enteev7	240	9	I	i	NN
cord-350836-1enteev7	240	10	signaling	signal	VBG
cord-350836-1enteev7	240	11	by	by	IN
cord-350836-1enteev7	240	12	IAV	IAV	NNP
cord-350836-1enteev7	240	13	DVGs	dvg	NNS
cord-350836-1enteev7	240	14	have	have	VBP
cord-350836-1enteev7	240	15	yet	yet	RB
cord-350836-1enteev7	240	16	to	to	TO
cord-350836-1enteev7	240	17	be	be	VB
cord-350836-1enteev7	240	18	elucidated	elucidate	VBN
cord-350836-1enteev7	240	19	,	,	,
cord-350836-1enteev7	240	20	although	although	IN
cord-350836-1enteev7	240	21	the	the	DT
cord-350836-1enteev7	240	22	level	level	NN
cord-350836-1enteev7	240	23	of	of	IN
cord-350836-1enteev7	240	24	exposure	exposure	NN
cord-350836-1enteev7	240	25	of	of	IN
cord-350836-1enteev7	240	26	the	the	DT
cord-350836-1enteev7	240	27	panhandle	panhandle	NN
cord-350836-1enteev7	240	28	may	may	MD
cord-350836-1enteev7	240	29	play	play	VB
cord-350836-1enteev7	240	30	a	a	DT
cord-350836-1enteev7	240	31	role	role	NN
cord-350836-1enteev7	240	32	.	.	.
cord-350836-1enteev7	241	1	While	while	IN
cord-350836-1enteev7	241	2	the	the	DT
cord-350836-1enteev7	241	3	full	full	JJ
cord-350836-1enteev7	241	4	extent	extent	NN
cord-350836-1enteev7	241	5	of	of	IN
cord-350836-1enteev7	241	6	MDA5	MDA5	NNP
cord-350836-1enteev7	241	7	interacting	interact	VBG
cord-350836-1enteev7	241	8	with	with	IN
cord-350836-1enteev7	241	9	DI	DI	NNP
cord-350836-1enteev7	241	10	RNA	RNA	NNP
cord-350836-1enteev7	241	11	is	be	VBZ
cord-350836-1enteev7	241	12	currently	currently	RB
cord-350836-1enteev7	241	13	unknown	unknown	JJ
cord-350836-1enteev7	241	14	,	,	,
cord-350836-1enteev7	241	15	MDA5	MDA5	NNP
cord-350836-1enteev7	241	16	appears	appear	VBZ
cord-350836-1enteev7	241	17	to	to	TO
cord-350836-1enteev7	241	18	be	be	VB
cord-350836-1enteev7	241	19	more	more	RBR
cord-350836-1enteev7	241	20	predominantly	predominantly	RB
cord-350836-1enteev7	241	21	activated	activate	VBN
cord-350836-1enteev7	241	22	by	by	IN
cord-350836-1enteev7	241	23	DVG	DVG	NNP
cord-350836-1enteev7	241	24	RNA	RNA	NNP
cord-350836-1enteev7	241	25	than	than	IN
cord-350836-1enteev7	241	26	RIG	rig	NN
cord-350836-1enteev7	241	27	-	-	:
cord-350836-1enteev7	241	28	I	-PRON-	PRP
cord-350836-1enteev7	241	29	specifically	specifically	RB
cord-350836-1enteev7	241	30	in	in	IN
cord-350836-1enteev7	241	31	dendritic	dendritic	JJ
cord-350836-1enteev7	241	32	cells	cell	NNS
cord-350836-1enteev7	241	33	early	early	RB
cord-350836-1enteev7	241	34	in	in	IN
cord-350836-1enteev7	241	35	the	the	DT
cord-350836-1enteev7	241	36	viral	viral	JJ
cord-350836-1enteev7	241	37	infection	infection	NN
cord-350836-1enteev7	241	38	cycle	cycle	NN
cord-350836-1enteev7	241	39	(	(	-LRB-
cord-350836-1enteev7	241	40	211	211	CD
cord-350836-1enteev7	241	41	)	)	-RRB-
cord-350836-1enteev7	241	42	,	,	,
cord-350836-1enteev7	241	43	which	which	WDT
cord-350836-1enteev7	241	44	may	may	MD
cord-350836-1enteev7	241	45	be	be	VB
cord-350836-1enteev7	241	46	a	a	DT
cord-350836-1enteev7	241	47	contributor	contributor	NN
cord-350836-1enteev7	241	48	toward	toward	IN
cord-350836-1enteev7	241	49	the	the	DT
cord-350836-1enteev7	241	50	phenomenon	phenomenon	NN
cord-350836-1enteev7	241	51	of	of	IN
cord-350836-1enteev7	241	52	DI	DI	NNP
cord-350836-1enteev7	241	53	particles	particle	NNS
cord-350836-1enteev7	241	54	enhancing	enhance	VBG
cord-350836-1enteev7	241	55	dendritic	dendritic	JJ
cord-350836-1enteev7	241	56	cell	cell	NN
cord-350836-1enteev7	241	57	maturation	maturation	NN
cord-350836-1enteev7	241	58	(	(	-LRB-
cord-350836-1enteev7	241	59	212	212	CD
cord-350836-1enteev7	241	60	)	)	-RRB-
cord-350836-1enteev7	241	61	.	.	.
cord-350836-1enteev7	242	1	The	the	DT
cord-350836-1enteev7	242	2	comparative	comparative	JJ
cord-350836-1enteev7	242	3	abilities	ability	NNS
cord-350836-1enteev7	242	4	for	for	IN
cord-350836-1enteev7	242	5	DI	DI	NNP
cord-350836-1enteev7	242	6	particles	particle	NNS
cord-350836-1enteev7	242	7	vs.	vs.	IN
cord-350836-1enteev7	242	8	infectious	infectious	JJ
cord-350836-1enteev7	242	9	virions	virion	NNS
cord-350836-1enteev7	242	10	to	to	TO
cord-350836-1enteev7	242	11	activate	activate	VB
cord-350836-1enteev7	242	12	RIG	rig	NN
cord-350836-1enteev7	242	13	-	-	:
cord-350836-1enteev7	242	14	I	I	NNP
cord-350836-1enteev7	242	15	and	and	CC
cord-350836-1enteev7	242	16	MDA5	MDA5	NNP
cord-350836-1enteev7	242	17	have	have	VBP
cord-350836-1enteev7	242	18	important	important	JJ
cord-350836-1enteev7	242	19	implications	implication	NNS
cord-350836-1enteev7	242	20	for	for	IN
cord-350836-1enteev7	242	21	understanding	understand	VBG
cord-350836-1enteev7	242	22	viral	viral	JJ
cord-350836-1enteev7	242	23	pathogenesis	pathogenesis	NN
cord-350836-1enteev7	242	24	and	and	CC
cord-350836-1enteev7	242	25	for	for	IN
cord-350836-1enteev7	242	26	vaccine	vaccine	NN
cord-350836-1enteev7	242	27	development	development	NN
cord-350836-1enteev7	242	28	.	.	.
cord-350836-1enteev7	243	1	There	there	EX
cord-350836-1enteev7	243	2	is	be	VBZ
cord-350836-1enteev7	243	3	a	a	DT
cord-350836-1enteev7	243	4	burgeoning	burgeon	VBG
cord-350836-1enteev7	243	5	interest	interest	NN
cord-350836-1enteev7	243	6	in	in	IN
cord-350836-1enteev7	243	7	this	this	DT
cord-350836-1enteev7	243	8	regard	regard	NN
cord-350836-1enteev7	243	9	,	,	,
cord-350836-1enteev7	243	10	especially	especially	RB
cord-350836-1enteev7	243	11	in	in	IN
cord-350836-1enteev7	243	12	populations	population	NNS
cord-350836-1enteev7	243	13	which	which	WDT
cord-350836-1enteev7	243	14	are	be	VBP
cord-350836-1enteev7	243	15	typically	typically	RB
cord-350836-1enteev7	243	16	more	more	RBR
cord-350836-1enteev7	243	17	challenging	challenging	JJ
cord-350836-1enteev7	243	18	to	to	TO
cord-350836-1enteev7	243	19	achieve	achieve	VB
cord-350836-1enteev7	243	20	successful	successful	JJ
cord-350836-1enteev7	243	21	preventative	preventative	JJ
cord-350836-1enteev7	243	22	vaccination	vaccination	NN
cord-350836-1enteev7	243	23	,	,	,
cord-350836-1enteev7	243	24	such	such	JJ
cord-350836-1enteev7	243	25	as	as	IN
cord-350836-1enteev7	243	26	elderly	elderly	JJ
cord-350836-1enteev7	243	27	populations	population	NNS
cord-350836-1enteev7	243	28	with	with	IN
cord-350836-1enteev7	243	29	IAV	IAV	NNP
cord-350836-1enteev7	243	30	vaccination	vaccination	NN
cord-350836-1enteev7	243	31	(	(	-LRB-
cord-350836-1enteev7	243	32	213	213	CD
cord-350836-1enteev7	243	33	)	)	-RRB-
cord-350836-1enteev7	243	34	.	.	.
cord-350836-1enteev7	244	1	Elderly	elderly	JJ
cord-350836-1enteev7	244	2	populations	population	NNS
cord-350836-1enteev7	244	3	in	in	IN
cord-350836-1enteev7	244	4	general	general	JJ
cord-350836-1enteev7	244	5	do	do	VBP
cord-350836-1enteev7	244	6	not	not	RB
cord-350836-1enteev7	244	7	develop	develop	VB
cord-350836-1enteev7	244	8	as	as	RB
cord-350836-1enteev7	244	9	strong	strong	JJ
cord-350836-1enteev7	244	10	of	of	IN
cord-350836-1enteev7	244	11	memory	memory	NN
cord-350836-1enteev7	244	12	immune	immune	JJ
cord-350836-1enteev7	244	13	responses	response	NNS
cord-350836-1enteev7	244	14	to	to	IN
cord-350836-1enteev7	244	15	vaccines	vaccine	NNS
cord-350836-1enteev7	244	16	as	as	IN
cord-350836-1enteev7	244	17	their	-PRON-	PRP$
cord-350836-1enteev7	244	18	younger	young	JJR
cord-350836-1enteev7	244	19	counterparts	counterpart	NNS
cord-350836-1enteev7	244	20	(	(	-LRB-
cord-350836-1enteev7	244	21	214	214	CD
cord-350836-1enteev7	244	22	)	)	-RRB-
cord-350836-1enteev7	244	23	(	(	-LRB-
cord-350836-1enteev7	244	24	215	215	CD
cord-350836-1enteev7	244	25	)	)	-RRB-
cord-350836-1enteev7	244	26	(	(	-LRB-
cord-350836-1enteev7	244	27	216	216	CD
cord-350836-1enteev7	244	28	)	)	-RRB-
cord-350836-1enteev7	244	29	(	(	-LRB-
cord-350836-1enteev7	244	30	217	217	CD
cord-350836-1enteev7	244	31	)	)	-RRB-
cord-350836-1enteev7	244	32	and	and	CC
cord-350836-1enteev7	244	33	have	have	VBP
cord-350836-1enteev7	244	34	been	be	VBN
cord-350836-1enteev7	244	35	found	find	VBN
cord-350836-1enteev7	245	1	to	to	TO
cord-350836-1enteev7	245	2	have	have	VB
cord-350836-1enteev7	245	3	decreased	decrease	VBN
cord-350836-1enteev7	245	4	RIG	rig	NN
cord-350836-1enteev7	246	1	-I	-i	WDT
cord-350836-1enteev7	246	2	mediated	mediate	VBD
cord-350836-1enteev7	246	3	IFN1	IFN1	NNP
cord-350836-1enteev7	246	4	signaling	signal	VBG
cord-350836-1enteev7	246	5	(	(	-LRB-
cord-350836-1enteev7	246	6	218	218	CD
cord-350836-1enteev7	246	7	)	)	-RRB-
cord-350836-1enteev7	246	8	.	.	.
cord-350836-1enteev7	247	1	Correspondingly	correspondingly	RB
cord-350836-1enteev7	247	2	,	,	,
cord-350836-1enteev7	247	3	the	the	DT
cord-350836-1enteev7	247	4	influenza	influenza	NN
cord-350836-1enteev7	247	5	vaccine	vaccine	NN
cord-350836-1enteev7	247	6	has	have	VBZ
cord-350836-1enteev7	247	7	been	be	VBN
cord-350836-1enteev7	247	8	shown	show	VBN
cord-350836-1enteev7	247	9	to	to	TO
cord-350836-1enteev7	247	10	decrease	decrease	VB
cord-350836-1enteev7	247	11	in	in	IN
cord-350836-1enteev7	247	12	effectiveness	effectiveness	NN
cord-350836-1enteev7	247	13	in	in	IN
cord-350836-1enteev7	247	14	older	old	JJR
cord-350836-1enteev7	247	15	populations	population	NNS
cord-350836-1enteev7	247	16	as	as	IN
cord-350836-1enteev7	247	17	the	the	DT
cord-350836-1enteev7	247	18	influenza	influenza	NN
cord-350836-1enteev7	247	19	season	season	NN
cord-350836-1enteev7	247	20	progresses	progress	VBZ
cord-350836-1enteev7	247	21	(	(	-LRB-
cord-350836-1enteev7	247	22	219	219	CD
cord-350836-1enteev7	247	23	)	)	-RRB-
cord-350836-1enteev7	247	24	.	.	.
cord-350836-1enteev7	248	1	A	a	DT
cord-350836-1enteev7	248	2	DI	di	NN
cord-350836-1enteev7	248	3	-	-	HYPH
cord-350836-1enteev7	248	4	vaccine	vaccine	NN
cord-350836-1enteev7	248	5	that	that	WDT
cord-350836-1enteev7	248	6	strongly	strongly	RB
cord-350836-1enteev7	248	7	activates	activate	VBZ
cord-350836-1enteev7	248	8	innate	innate	JJ
cord-350836-1enteev7	248	9	immune	immune	JJ
cord-350836-1enteev7	248	10	cells	cell	NNS
cord-350836-1enteev7	248	11	and	and	CC
cord-350836-1enteev7	248	12	increases	increase	VBZ
cord-350836-1enteev7	248	13	the	the	DT
cord-350836-1enteev7	248	14	adaptive	adaptive	JJ
cord-350836-1enteev7	248	15	immune	immune	JJ
cord-350836-1enteev7	248	16	response	response	NN
cord-350836-1enteev7	248	17	could	could	MD
cord-350836-1enteev7	248	18	therefore	therefore	RB
cord-350836-1enteev7	248	19	potentially	potentially	RB
cord-350836-1enteev7	248	20	boost	boost	VB
cord-350836-1enteev7	248	21	the	the	DT
cord-350836-1enteev7	248	22	immune	immune	JJ
cord-350836-1enteev7	248	23	responses	response	NNS
cord-350836-1enteev7	248	24	to	to	IN
cord-350836-1enteev7	248	25	vaccines	vaccine	NNS
cord-350836-1enteev7	248	26	in	in	IN
cord-350836-1enteev7	248	27	more	more	RBR
cord-350836-1enteev7	248	28	vulnerable	vulnerable	JJ
cord-350836-1enteev7	248	29	populations	population	NNS
cord-350836-1enteev7	248	30	.	.	.
cord-350836-1enteev7	249	1	Additionally	additionally	RB
cord-350836-1enteev7	249	2	,	,	,
cord-350836-1enteev7	249	3	DI	DI	NNP
cord-350836-1enteev7	249	4	particles	particle	NNS
cord-350836-1enteev7	249	5	have	have	VBP
cord-350836-1enteev7	249	6	shown	show	VBN
cord-350836-1enteev7	249	7	to	to	TO
cord-350836-1enteev7	249	8	be	be	VB
cord-350836-1enteev7	249	9	an	an	DT
cord-350836-1enteev7	249	10	important	important	JJ
cord-350836-1enteev7	249	11	contributor	contributor	NN
cord-350836-1enteev7	249	12	of	of	IN
cord-350836-1enteev7	249	13	viral	viral	JJ
cord-350836-1enteev7	249	14	persistence	persistence	NN
cord-350836-1enteev7	249	15	(	(	-LRB-
cord-350836-1enteev7	249	16	200	200	CD
cord-350836-1enteev7	249	17	,	,	,
cord-350836-1enteev7	249	18	220	220	CD
cord-350836-1enteev7	249	19	,	,	,
cord-350836-1enteev7	249	20	221	221	CD
cord-350836-1enteev7	249	21	)	)	-RRB-
cord-350836-1enteev7	249	22	.	.	.
cord-350836-1enteev7	250	1	This	this	DT
cord-350836-1enteev7	250	2	raises	raise	VBZ
cord-350836-1enteev7	250	3	the	the	DT
cord-350836-1enteev7	250	4	question	question	NN
cord-350836-1enteev7	250	5	of	of	IN
cord-350836-1enteev7	250	6	whether	whether	IN
cord-350836-1enteev7	250	7	a	a	DT
cord-350836-1enteev7	250	8	viral	viral	JJ
cord-350836-1enteev7	250	9	infection	infection	NN
cord-350836-1enteev7	250	10	may	may	MD
cord-350836-1enteev7	250	11	alternate	alternate	VB
cord-350836-1enteev7	250	12	between	between	IN
cord-350836-1enteev7	250	13	producing	produce	VBG
cord-350836-1enteev7	250	14	primarily	primarily	RB
cord-350836-1enteev7	250	15	infectious	infectious	JJ
cord-350836-1enteev7	250	16	virions	virion	NNS
cord-350836-1enteev7	250	17	which	which	WDT
cord-350836-1enteev7	250	18	eventually	eventually	RB
cord-350836-1enteev7	250	19	activates	activate	VBZ
cord-350836-1enteev7	250	20	the	the	DT
cord-350836-1enteev7	250	21	innate	innate	JJ
cord-350836-1enteev7	250	22	immune	immune	JJ
cord-350836-1enteev7	250	23	response	response	NN
cord-350836-1enteev7	250	24	and	and	CC
cord-350836-1enteev7	250	25	producing	produce	VBG
cord-350836-1enteev7	250	26	primarily	primarily	RB
cord-350836-1enteev7	250	27	DI	DI	NNP
cord-350836-1enteev7	250	28	particles	particle	NNS
cord-350836-1enteev7	250	29	which	which	WDT
cord-350836-1enteev7	250	30	requires	require	VBZ
cord-350836-1enteev7	250	31	less	less	JJR
cord-350836-1enteev7	250	32	cellular	cellular	JJ
cord-350836-1enteev7	250	33	activity	activity	NN
cord-350836-1enteev7	250	34	but	but	CC
cord-350836-1enteev7	250	35	may	may	MD
cord-350836-1enteev7	250	36	initiate	initiate	VB
cord-350836-1enteev7	250	37	an	an	DT
cord-350836-1enteev7	250	38	even	even	RB
cord-350836-1enteev7	250	39	stronger	strong	JJR
cord-350836-1enteev7	250	40	innate	innate	JJ
cord-350836-1enteev7	250	41	immune	immune	JJ
cord-350836-1enteev7	250	42	response	response	NN
cord-350836-1enteev7	250	43	(	(	-LRB-
cord-350836-1enteev7	250	44	222	222	CD
cord-350836-1enteev7	250	45	)	)	-RRB-
cord-350836-1enteev7	250	46	(	(	-LRB-
cord-350836-1enteev7	250	47	223	223	CD
cord-350836-1enteev7	250	48	)	)	-RRB-
cord-350836-1enteev7	250	49	(	(	-LRB-
cord-350836-1enteev7	250	50	224	224	CD
cord-350836-1enteev7	250	51	)	)	-RRB-
cord-350836-1enteev7	250	52	.	.	.
cord-350836-1enteev7	251	1	Taken	take	VBN
cord-350836-1enteev7	251	2	altogether	altogether	RB
cord-350836-1enteev7	251	3	,	,	,
cord-350836-1enteev7	251	4	DI	DI	NNP
cord-350836-1enteev7	251	5	particles	particle	NNS
cord-350836-1enteev7	251	6	provide	provide	VBP
cord-350836-1enteev7	251	7	yet	yet	RB
cord-350836-1enteev7	251	8	another	another	DT
cord-350836-1enteev7	251	9	layer	layer	NN
cord-350836-1enteev7	251	10	of	of	IN
cord-350836-1enteev7	251	11	distinction	distinction	NN
cord-350836-1enteev7	251	12	between	between	IN
cord-350836-1enteev7	251	13	RIG	rig	NN
cord-350836-1enteev7	251	14	-	-	:
cord-350836-1enteev7	251	15	I	I	NNP
cord-350836-1enteev7	251	16	and	and	CC
cord-350836-1enteev7	251	17	MDA5	MDA5	NNP
cord-350836-1enteev7	251	18	in	in	IN
cord-350836-1enteev7	251	19	terms	term	NNS
cord-350836-1enteev7	251	20	of	of	IN
cord-350836-1enteev7	251	21	how	how	WRB
cord-350836-1enteev7	251	22	each	each	DT
cord-350836-1enteev7	251	23	recognizes	recognize	VBZ
cord-350836-1enteev7	251	24	different	different	JJ
cord-350836-1enteev7	251	25	species	specie	NNS
cord-350836-1enteev7	251	26	of	of	IN
cord-350836-1enteev7	251	27	dsRNA	dsrna	NN
cord-350836-1enteev7	251	28	.	.	.
cord-350836-1enteev7	252	1	The	the	DT
cord-350836-1enteev7	252	2	preference	preference	NN
cord-350836-1enteev7	252	3	for	for	IN
cord-350836-1enteev7	252	4	specific	specific	JJ
cord-350836-1enteev7	252	5	RNA	RNA	NNP
cord-350836-1enteev7	252	6	species	specie	NNS
cord-350836-1enteev7	252	7	by	by	IN
cord-350836-1enteev7	252	8	RIG	rig	NN
cord-350836-1enteev7	252	9	-	-	:
cord-350836-1enteev7	252	10	I	I	NNP
cord-350836-1enteev7	252	11	and	and	CC
cord-350836-1enteev7	252	12	MDA5	MDA5	NNP
cord-350836-1enteev7	252	13	allow	allow	VB
cord-350836-1enteev7	252	14	for	for	IN
cord-350836-1enteev7	252	15	them	-PRON-	PRP
cord-350836-1enteev7	252	16	to	to	TO
cord-350836-1enteev7	252	17	distinguish	distinguish	VB
cord-350836-1enteev7	252	18	between	between	IN
cord-350836-1enteev7	252	19	viral	viral	JJ
cord-350836-1enteev7	252	20	RNA	RNA	NNP
cord-350836-1enteev7	252	21	and	and	CC
cord-350836-1enteev7	252	22	host	host	NN
cord-350836-1enteev7	252	23	RNA	RNA	NNP
cord-350836-1enteev7	252	24	in	in	IN
cord-350836-1enteev7	252	25	most	most	JJS
cord-350836-1enteev7	252	26	circumstances	circumstance	NNS
cord-350836-1enteev7	252	27	(	(	-LRB-
cord-350836-1enteev7	252	28	225	225	CD
cord-350836-1enteev7	252	29	)	)	-RRB-
cord-350836-1enteev7	252	30	,	,	,
cord-350836-1enteev7	252	31	although	although	IN
cord-350836-1enteev7	252	32	the	the	DT
cord-350836-1enteev7	252	33	specific	specific	JJ
cord-350836-1enteev7	252	34	mechanisms	mechanism	NNS
cord-350836-1enteev7	252	35	of	of	IN
cord-350836-1enteev7	252	36	distinction	distinction	NN
cord-350836-1enteev7	252	37	are	be	VBP
cord-350836-1enteev7	252	38	not	not	RB
cord-350836-1enteev7	252	39	as	as	RB
cord-350836-1enteev7	252	40	clear	clear	JJ
cord-350836-1enteev7	252	41	for	for	IN
cord-350836-1enteev7	252	42	MDA5	MDA5	NNP
cord-350836-1enteev7	252	43	as	as	IN
cord-350836-1enteev7	252	44	for	for	IN
cord-350836-1enteev7	252	45	RIG	rig	NN
cord-350836-1enteev7	252	46	-	-	HYPH
cord-350836-1enteev7	252	47	I.	I.	NNP
cord-350836-1enteev7	252	48	Studies	study	NNS
cord-350836-1enteev7	252	49	from	from	IN
cord-350836-1enteev7	252	50	clinical	clinical	JJ
cord-350836-1enteev7	252	51	cases	case	NNS
cord-350836-1enteev7	252	52	of	of	IN
cord-350836-1enteev7	252	53	MDA5	MDA5	NNP
cord-350836-1enteev7	252	54	mutations	mutation	NNS
cord-350836-1enteev7	252	55	provide	provide	VBP
cord-350836-1enteev7	252	56	contradictory	contradictory	JJ
cord-350836-1enteev7	252	57	models	model	NNS
cord-350836-1enteev7	252	58	,	,	,
cord-350836-1enteev7	252	59	with	with	IN
cord-350836-1enteev7	252	60	certain	certain	JJ
cord-350836-1enteev7	252	61	mutations	mutation	NNS
cord-350836-1enteev7	252	62	found	find	VBN
cord-350836-1enteev7	252	63	in	in	IN
cord-350836-1enteev7	252	64	Aicardi	Aicardi	NNP
cord-350836-1enteev7	252	65	-	-	HYPH
cord-350836-1enteev7	252	66	Goutières	Goutières	NNP
cord-350836-1enteev7	252	67	syndrome	syndrome	NN
cord-350836-1enteev7	252	68	(	(	-LRB-
cord-350836-1enteev7	252	69	AGS	AGS	NNP
cord-350836-1enteev7	252	70	)	)	-RRB-
cord-350836-1enteev7	252	71	increasing	increase	VBG
cord-350836-1enteev7	252	72	MDA5	mda5	JJ
cord-350836-1enteev7	252	73	avidity	avidity	NN
cord-350836-1enteev7	252	74	for	for	IN
cord-350836-1enteev7	252	75	self	self	NN
cord-350836-1enteev7	252	76	RNA	RNA	NNP
cord-350836-1enteev7	252	77	(	(	-LRB-
cord-350836-1enteev7	252	78	226	226	CD
cord-350836-1enteev7	252	79	)	)	-RRB-
cord-350836-1enteev7	252	80	with	with	IN
cord-350836-1enteev7	252	81	Alu	Alu	NNP
cord-350836-1enteev7	252	82	retroelements	retroelement	NNS
cord-350836-1enteev7	252	83	found	find	VBD
cord-350836-1enteev7	252	84	to	to	TO
cord-350836-1enteev7	252	85	be	be	VB
cord-350836-1enteev7	252	86	significantly	significantly	RB
cord-350836-1enteev7	252	87	enriched	enrich	VBN
cord-350836-1enteev7	252	88	for	for	IN
cord-350836-1enteev7	252	89	interaction	interaction	NN
cord-350836-1enteev7	252	90	with	with	IN
cord-350836-1enteev7	252	91	AGS	AGS	NNP
cord-350836-1enteev7	252	92	MDA5	MDA5	NNP
cord-350836-1enteev7	252	93	mutations	mutation	NNS
cord-350836-1enteev7	252	94	(	(	-LRB-
cord-350836-1enteev7	252	95	227	227	CD
cord-350836-1enteev7	252	96	)	)	-RRB-
cord-350836-1enteev7	252	97	.	.	.
cord-350836-1enteev7	253	1	The	the	DT
cord-350836-1enteev7	253	2	modification	modification	NN
cord-350836-1enteev7	253	3	of	of	IN
cord-350836-1enteev7	253	4	dsRNA	dsrna	NN
cord-350836-1enteev7	253	5	by	by	IN
cord-350836-1enteev7	253	6	host	host	NN
cord-350836-1enteev7	253	7	cells	cell	NNS
cord-350836-1enteev7	253	8	may	may	MD
cord-350836-1enteev7	253	9	be	be	VB
cord-350836-1enteev7	253	10	a	a	DT
cord-350836-1enteev7	253	11	primary	primary	JJ
cord-350836-1enteev7	253	12	inhibitor	inhibitor	NN
cord-350836-1enteev7	253	13	of	of	IN
cord-350836-1enteev7	253	14	MDA5	mda5	JJ
cord-350836-1enteev7	253	15	activation	activation	NN
cord-350836-1enteev7	253	16	by	by	IN
cord-350836-1enteev7	253	17	host	host	NN
cord-350836-1enteev7	253	18	RNA	RNA	NNP
cord-350836-1enteev7	253	19	as	as	IN
cord-350836-1enteev7	253	20	knockout	knockout	NN
cord-350836-1enteev7	253	21	of	of	IN
cord-350836-1enteev7	253	22	adenosine	adenosine	NN
cord-350836-1enteev7	253	23	deaminase	deaminase	NNP
cord-350836-1enteev7	253	24	(	(	-LRB-
cord-350836-1enteev7	253	25	ADAR1	ADAR1	NNP
cord-350836-1enteev7	253	26	)	)	-RRB-
cord-350836-1enteev7	253	27	,	,	,
cord-350836-1enteev7	253	28	which	which	WDT
cord-350836-1enteev7	253	29	weakens	weaken	VBZ
cord-350836-1enteev7	253	30	dsRNA	dsrna	NN
cord-350836-1enteev7	253	31	structures	structure	NNS
cord-350836-1enteev7	253	32	,	,	,
cord-350836-1enteev7	253	33	allows	allow	VBZ
cord-350836-1enteev7	253	34	wild	wild	JJ
cord-350836-1enteev7	253	35	-	-	HYPH
cord-350836-1enteev7	253	36	type	type	NN
cord-350836-1enteev7	253	37	MDA5	MDA5	NNP
cord-350836-1enteev7	253	38	to	to	TO
cord-350836-1enteev7	253	39	be	be	VB
cord-350836-1enteev7	253	40	activated	activate	VBN
cord-350836-1enteev7	253	41	by	by	IN
cord-350836-1enteev7	253	42	Alu	Alu	NNP
cord-350836-1enteev7	253	43	retroelements	retroelement	NNS
cord-350836-1enteev7	253	44	(	(	-LRB-
cord-350836-1enteev7	253	45	227	227	CD
cord-350836-1enteev7	253	46	)	)	-RRB-
cord-350836-1enteev7	253	47	.	.	.
cord-350836-1enteev7	254	1	However	however	RB
cord-350836-1enteev7	254	2	,	,	,
cord-350836-1enteev7	254	3	other	other	JJ
cord-350836-1enteev7	254	4	MDA5	MDA5	NNP
cord-350836-1enteev7	254	5	mutations	mutation	NNS
cord-350836-1enteev7	254	6	decrease	decrease	VBP
cord-350836-1enteev7	254	7	affinity	affinity	NN
cord-350836-1enteev7	254	8	for	for	IN
cord-350836-1enteev7	254	9	known	know	VBN
cord-350836-1enteev7	254	10	MDA5	mda5	JJ
cord-350836-1enteev7	254	11	ligands	ligand	NNS
cord-350836-1enteev7	254	12	and	and	CC
cord-350836-1enteev7	254	13	ATPase	ATPase	NNP
cord-350836-1enteev7	254	14	activity	activity	NN
cord-350836-1enteev7	254	15	,	,	,
cord-350836-1enteev7	254	16	yet	yet	CC
cord-350836-1enteev7	254	17	still	still	RB
cord-350836-1enteev7	254	18	demonstrate	demonstrate	VBP
cord-350836-1enteev7	254	19	increased	increase	VBN
cord-350836-1enteev7	254	20	IFNβ	IFNβ	NNS
cord-350836-1enteev7	254	21	expression	expression	NN
cord-350836-1enteev7	254	22	(	(	-LRB-
cord-350836-1enteev7	254	23	228	228	CD
cord-350836-1enteev7	254	24	,	,	,
cord-350836-1enteev7	254	25	229	229	CD
cord-350836-1enteev7	254	26	)	)	-RRB-
cord-350836-1enteev7	254	27	.	.	.
cord-350836-1enteev7	255	1	For	for	IN
cord-350836-1enteev7	255	2	RIG	rig	NN
cord-350836-1enteev7	255	3	-	-	:
cord-350836-1enteev7	255	4	I	i	NN
cord-350836-1enteev7	255	5	,	,	,
cord-350836-1enteev7	255	6	a	a	DT
cord-350836-1enteev7	255	7	highly	highly	RB
cord-350836-1enteev7	255	8	conserved	conserved	JJ
cord-350836-1enteev7	255	9	residue	residue	NN
cord-350836-1enteev7	255	10	in	in	IN
cord-350836-1enteev7	255	11	the	the	DT
cord-350836-1enteev7	255	12	C	C	NNP
cord-350836-1enteev7	255	13	-	-	HYPH
cord-350836-1enteev7	255	14	terminal	terminal	NN
cord-350836-1enteev7	255	15	RNA	RNA	NNP
cord-350836-1enteev7	255	16	binding	binding	NN
cord-350836-1enteev7	255	17	pocket	pocket	NN
cord-350836-1enteev7	255	18	(	(	-LRB-
cord-350836-1enteev7	255	19	H830	H830	NNP
cord-350836-1enteev7	255	20	)	)	-RRB-
cord-350836-1enteev7	255	21	has	have	VBZ
cord-350836-1enteev7	255	22	been	be	VBN
cord-350836-1enteev7	255	23	found	find	VBN
cord-350836-1enteev7	255	24	to	to	IN
cord-350836-1enteev7	255	25	sterically	sterically	RB
cord-350836-1enteev7	255	26	exclude	exclude	VB
cord-350836-1enteev7	255	27	canonical	canonical	JJ
cord-350836-1enteev7	255	28	self	self	NN
cord-350836-1enteev7	255	29	-	-	HYPH
cord-350836-1enteev7	255	30	RNA	RNA	NNP
cord-350836-1enteev7	255	31	by	by	IN
cord-350836-1enteev7	255	32	the	the	DT
cord-350836-1enteev7	255	33	means	mean	NNS
cord-350836-1enteev7	255	34	of	of	IN
cord-350836-1enteev7	255	35	the	the	DT
cord-350836-1enteev7	255	36	N	N	NNP
cord-350836-1enteev7	255	37	1	1	CD
cord-350836-1enteev7	255	38	-2	-2	NN
cord-350836-1enteev7	255	39	′	′	CD
cord-350836-1enteev7	255	40	O	o	NN
cord-350836-1enteev7	255	41	-	-	HYPH
cord-350836-1enteev7	255	42	methyl	methyl	NN
cord-350836-1enteev7	255	43	self	self	NN
cord-350836-1enteev7	255	44	-	-	HYPH
cord-350836-1enteev7	255	45	RNA	RNA	NNP
cord-350836-1enteev7	255	46	motif	motif	NN
cord-350836-1enteev7	255	47	,	,	,
cord-350836-1enteev7	255	48	also	also	RB
cord-350836-1enteev7	255	49	known	know	VBN
cord-350836-1enteev7	255	50	as	as	IN
cord-350836-1enteev7	255	51	Cap1	Cap1	NNP
cord-350836-1enteev7	255	52	RNA	RNA	NNP
cord-350836-1enteev7	255	53	(	(	-LRB-
cord-350836-1enteev7	255	54	61	61	CD
cord-350836-1enteev7	255	55	,	,	,
cord-350836-1enteev7	255	56	230	230	CD
cord-350836-1enteev7	255	57	)	)	-RRB-
cord-350836-1enteev7	255	58	.	.	.
cord-350836-1enteev7	256	1	This	this	DT
cord-350836-1enteev7	256	2	results	result	VBZ
cord-350836-1enteev7	256	3	in	in	IN
cord-350836-1enteev7	256	4	a	a	DT
cord-350836-1enteev7	256	5	low	low	JJ
cord-350836-1enteev7	256	6	binding	bind	VBG
cord-350836-1enteev7	256	7	affinity	affinity	NN
cord-350836-1enteev7	256	8	of	of	IN
cord-350836-1enteev7	256	9	RIG	rig	NN
cord-350836-1enteev7	256	10	-	-	:
cord-350836-1enteev7	256	11	I	i	NN
cord-350836-1enteev7	256	12	to	to	TO
cord-350836-1enteev7	256	13	cellular	cellular	JJ
cord-350836-1enteev7	256	14	Cap1	Cap1	NNP
cord-350836-1enteev7	256	15	RNA	RNA	NNP
cord-350836-1enteev7	256	16	and	and	CC
cord-350836-1enteev7	256	17	decreased	decrease	VBD
cord-350836-1enteev7	256	18	ATPase	ATPase	NNP
cord-350836-1enteev7	256	19	activity	activity	NN
cord-350836-1enteev7	256	20	as	as	IN
cord-350836-1enteev7	256	21	compared	compare	VBN
cord-350836-1enteev7	256	22	to	to	IN
cord-350836-1enteev7	256	23	PAMP	PAMP	NNP
cord-350836-1enteev7	256	24	(	(	-LRB-
cord-350836-1enteev7	256	25	dsRNA	dsrna	NN
cord-350836-1enteev7	256	26	)	)	-RRB-
cord-350836-1enteev7	256	27	(	(	-LRB-
cord-350836-1enteev7	256	28	61	61	CD
cord-350836-1enteev7	256	29	,	,	,
cord-350836-1enteev7	256	30	231	231	CD
cord-350836-1enteev7	256	31	)	)	-RRB-
cord-350836-1enteev7	256	32	.	.	.
cord-350836-1enteev7	257	1	Flaviviruses	flavivirus	NNS
cord-350836-1enteev7	257	2	take	take	VBP
cord-350836-1enteev7	257	3	advantage	advantage	NN
cord-350836-1enteev7	257	4	of	of	IN
cord-350836-1enteev7	257	5	this	this	DT
cord-350836-1enteev7	257	6	precise	precise	JJ
cord-350836-1enteev7	257	7	discrimination	discrimination	NN
cord-350836-1enteev7	257	8	by	by	IN
cord-350836-1enteev7	257	9	encoding	encode	VBG
cord-350836-1enteev7	257	10	a	a	DT
cord-350836-1enteev7	257	11	viral	viral	JJ
cord-350836-1enteev7	257	12	2	2	CD
cord-350836-1enteev7	257	13	′	′	CD
cord-350836-1enteev7	257	14	-O	-O	NNS
cord-350836-1enteev7	257	15	-	-	HYPH
cord-350836-1enteev7	257	16	methyltransferase	methyltransferase	JJ
cord-350836-1enteev7	257	17	capable	capable	JJ
cord-350836-1enteev7	257	18	of	of	IN
cord-350836-1enteev7	257	19	N	n	CD
cord-350836-1enteev7	257	20	1	1	CD
cord-350836-1enteev7	257	21	-2	-2	CD
cord-350836-1enteev7	258	1	′	′	CD
cord-350836-1enteev7	259	1	O	o	UH
cord-350836-1enteev7	259	2	-	-	HYPH
cord-350836-1enteev7	259	3	methylating	methylate	VBG
cord-350836-1enteev7	259	4	its	-PRON-	PRP$
cord-350836-1enteev7	259	5	positive	positive	JJ
cord-350836-1enteev7	259	6	-	-	HYPH
cord-350836-1enteev7	259	7	strand	strand	NN
cord-350836-1enteev7	259	8	RNA	RNA	NNP
cord-350836-1enteev7	259	9	genome	genome	NN
cord-350836-1enteev7	259	10	in	in	IN
cord-350836-1enteev7	259	11	order	order	NN
cord-350836-1enteev7	259	12	to	to	TO
cord-350836-1enteev7	259	13	evade	evade	VB
cord-350836-1enteev7	259	14	RIG	rig	NN
cord-350836-1enteev7	259	15	-	-	:
cord-350836-1enteev7	259	16	I	-PRON-	PRP
cord-350836-1enteev7	259	17	recognition	recognition	NN
cord-350836-1enteev7	259	18	and	and	CC
cord-350836-1enteev7	259	19	IFN1	IFN1	NNP
cord-350836-1enteev7	259	20	activation	activation	NN
cord-350836-1enteev7	259	21	(	(	-LRB-
cord-350836-1enteev7	259	22	230	230	CD
cord-350836-1enteev7	259	23	)	)	-RRB-
cord-350836-1enteev7	259	24	.	.	.
cord-350836-1enteev7	260	1	Conversely	conversely	RB
cord-350836-1enteev7	260	2	,	,	,
cord-350836-1enteev7	260	3	the	the	DT
cord-350836-1enteev7	260	4	mutations	mutation	NNS
cord-350836-1enteev7	260	5	E373A	E373A	NNP
cord-350836-1enteev7	260	6	and	and	CC
cord-350836-1enteev7	260	7	C268F	C268F	NNP
cord-350836-1enteev7	260	8	found	find	VBN
cord-350836-1enteev7	260	9	in	in	IN
cord-350836-1enteev7	260	10	the	the	DT
cord-350836-1enteev7	260	11	RIG-	RIG-	NNP
cord-350836-1enteev7	261	1	I	-PRON-	PRP
cord-350836-1enteev7	261	2	protein	protein	VBP
cord-350836-1enteev7	261	3	in	in	IN
cord-350836-1enteev7	261	4	patients	patient	NNS
cord-350836-1enteev7	261	5	with	with	IN
cord-350836-1enteev7	261	6	auto	auto	NN
cord-350836-1enteev7	261	7	-	-	HYPH
cord-350836-1enteev7	261	8	immune	immune	JJ
cord-350836-1enteev7	261	9	disorder	disorder	NN
cord-350836-1enteev7	261	10	Singleton	Singleton	NNP
cord-350836-1enteev7	261	11	-	-	HYPH
cord-350836-1enteev7	261	12	Merten	Merten	NNP
cord-350836-1enteev7	261	13	syndrome	syndrome	NN
cord-350836-1enteev7	261	14	confer	confer	VBP
cord-350836-1enteev7	261	15	the	the	DT
cord-350836-1enteev7	261	16	ability	ability	NN
cord-350836-1enteev7	261	17	of	of	IN
cord-350836-1enteev7	261	18	the	the	DT
cord-350836-1enteev7	261	19	protein	protein	NN
cord-350836-1enteev7	261	20	to	to	TO
cord-350836-1enteev7	261	21	recognize	recognize	VB
cord-350836-1enteev7	261	22	Cap1	Cap1	NNP
cord-350836-1enteev7	261	23	RNA	RNA	NNP
cord-350836-1enteev7	261	24	and	and	CC
cord-350836-1enteev7	261	25	become	become	VBN
cord-350836-1enteev7	261	26	activated	activate	VBN
cord-350836-1enteev7	261	27	by	by	IN
cord-350836-1enteev7	261	28	ATP	ATP	NNP
cord-350836-1enteev7	261	29	dependent	dependent	JJ
cord-350836-1enteev7	261	30	and	and	CC
cord-350836-1enteev7	261	31	independent	independent	JJ
cord-350836-1enteev7	261	32	mechanisms	mechanism	NNS
cord-350836-1enteev7	261	33	,	,	,
cord-350836-1enteev7	261	34	respectively	respectively	RB
cord-350836-1enteev7	261	35	(	(	-LRB-
cord-350836-1enteev7	261	36	232	232	CD
cord-350836-1enteev7	261	37	)	)	-RRB-
cord-350836-1enteev7	261	38	.	.	.
cord-350836-1enteev7	262	1	Furthermore	furthermore	RB
cord-350836-1enteev7	262	2	,	,	,
cord-350836-1enteev7	262	3	the	the	DT
cord-350836-1enteev7	262	4	E373Q	E373Q	NNP
cord-350836-1enteev7	262	5	mutation	mutation	NN
cord-350836-1enteev7	262	6	of	of	IN
cord-350836-1enteev7	262	7	RIG	rig	NN
cord-350836-1enteev7	262	8	-	-	:
cord-350836-1enteev7	262	9	I	I	NNP
cord-350836-1enteev7	262	10	,	,	,
cord-350836-1enteev7	262	11	which	which	WDT
cord-350836-1enteev7	262	12	was	be	VBD
cord-350836-1enteev7	262	13	designed	design	VBN
cord-350836-1enteev7	262	14	to	to	TO
cord-350836-1enteev7	262	15	constitutively	constitutively	RB
cord-350836-1enteev7	262	16	bind	bind	VB
cord-350836-1enteev7	262	17	ATP	ATP	NNP
cord-350836-1enteev7	262	18	,	,	,
cord-350836-1enteev7	262	19	was	be	VBD
cord-350836-1enteev7	262	20	found	find	VBN
cord-350836-1enteev7	262	21	to	to	TO
cord-350836-1enteev7	262	22	increase	increase	VB
cord-350836-1enteev7	262	23	the	the	DT
cord-350836-1enteev7	262	24	affinity	affinity	NN
cord-350836-1enteev7	262	25	of	of	IN
cord-350836-1enteev7	262	26	RIG	rig	NN
cord-350836-1enteev7	262	27	-	-	:
cord-350836-1enteev7	262	28	I	-PRON-	PRP
cord-350836-1enteev7	262	29	with	with	IN
cord-350836-1enteev7	262	30	ribosomal	ribosomal	NNP
cord-350836-1enteev7	262	31	RNA	RNA	NNP
cord-350836-1enteev7	262	32	(	(	-LRB-
cord-350836-1enteev7	262	33	233	233	CD
cord-350836-1enteev7	262	34	)	)	-RRB-
cord-350836-1enteev7	262	35	.	.	.
cord-350836-1enteev7	263	1	It	-PRON-	PRP
cord-350836-1enteev7	263	2	is	be	VBZ
cord-350836-1enteev7	263	3	noteworthy	noteworthy	JJ
cord-350836-1enteev7	263	4	that	that	IN
cord-350836-1enteev7	263	5	host	host	NN
cord-350836-1enteev7	263	6	RNA	RNA	NNP
cord-350836-1enteev7	263	7	contains	contain	VBZ
cord-350836-1enteev7	263	8	additional	additional	JJ
cord-350836-1enteev7	263	9	internal	internal	JJ
cord-350836-1enteev7	263	10	RNA	RNA	NNP
cord-350836-1enteev7	263	11	modifications	modification	NNS
cord-350836-1enteev7	263	12	and	and	CC
cord-350836-1enteev7	263	13	non	non	JJ
cord-350836-1enteev7	263	14	-	-	JJ
cord-350836-1enteev7	263	15	Watson	Watson	NNP
cord-350836-1enteev7	263	16	-	-	HYPH
cord-350836-1enteev7	263	17	Crick	Crick	NNP
cord-350836-1enteev7	263	18	base	base	NN
cord-350836-1enteev7	263	19	pairing	pairing	NN
cord-350836-1enteev7	263	20	which	which	WDT
cord-350836-1enteev7	263	21	can	can	MD
cord-350836-1enteev7	263	22	inhibit	inhibit	VB
cord-350836-1enteev7	263	23	activation	activation	NN
cord-350836-1enteev7	263	24	of	of	IN
cord-350836-1enteev7	263	25	the	the	DT
cord-350836-1enteev7	263	26	other	other	JJ
cord-350836-1enteev7	263	27	known	know	VBN
cord-350836-1enteev7	263	28	dsRNA	dsrna	NN
cord-350836-1enteev7	263	29	-	-	HYPH
cord-350836-1enteev7	263	30	sensing	sense	VBG
cord-350836-1enteev7	263	31	protein	protein	NN
cord-350836-1enteev7	263	32	,	,	,
cord-350836-1enteev7	263	33	the	the	DT
cord-350836-1enteev7	263	34	interferon	interferon	NN
cord-350836-1enteev7	263	35	-	-	HYPH
cord-350836-1enteev7	263	36	induced	induce	VBN
cord-350836-1enteev7	263	37	double	double	RB
cord-350836-1enteev7	263	38	-	-	HYPH
cord-350836-1enteev7	263	39	stranded	strand	VBN
cord-350836-1enteev7	263	40	RNA	RNA	NNP
cord-350836-1enteev7	263	41	-	-	HYPH
cord-350836-1enteev7	263	42	activated	activate	VBN
cord-350836-1enteev7	263	43	protein	protein	NN
cord-350836-1enteev7	263	44	kinase	kinase	NN
cord-350836-1enteev7	263	45	(	(	-LRB-
cord-350836-1enteev7	263	46	PKR	PKR	NNP
cord-350836-1enteev7	263	47	)	)	-RRB-
cord-350836-1enteev7	263	48	(	(	-LRB-
cord-350836-1enteev7	263	49	234	234	CD
cord-350836-1enteev7	263	50	)	)	-RRB-
cord-350836-1enteev7	263	51	,	,	,
cord-350836-1enteev7	263	52	and	and	CC
cord-350836-1enteev7	263	53	it	-PRON-	PRP
cord-350836-1enteev7	263	54	is	be	VBZ
cord-350836-1enteev7	263	55	known	know	VBN
cord-350836-1enteev7	263	56	that	that	IN
cord-350836-1enteev7	263	57	synthetic	synthetic	JJ
cord-350836-1enteev7	263	58	5	5	CD
cord-350836-1enteev7	263	59	′	′	CD
cord-350836-1enteev7	263	60	triphosphorylated	triphosphorylate	VBN
cord-350836-1enteev7	263	61	RNA	RNA	NNP
cord-350836-1enteev7	263	62	containing	contain	VBG
cord-350836-1enteev7	263	63	pseudouridine	pseudouridine	NN
cord-350836-1enteev7	263	64	,	,	,
cord-350836-1enteev7	263	65	2-thiouridine	2-thiouridine	CD
cord-350836-1enteev7	263	66	or	or	CC
cord-350836-1enteev7	263	67	2	2	CD
cord-350836-1enteev7	263	68	′	′	CD
cord-350836-1enteev7	263	69	-O	-o	RB
cord-350836-1enteev7	263	70	-	-	HYPH
cord-350836-1enteev7	263	71	methylated	methylated	JJ
cord-350836-1enteev7	263	72	uridine	uridine	NN
cord-350836-1enteev7	263	73	has	have	VBZ
cord-350836-1enteev7	263	74	significantly	significantly	RB
cord-350836-1enteev7	263	75	decreased	decrease	VBN
cord-350836-1enteev7	263	76	ability	ability	NN
cord-350836-1enteev7	263	77	to	to	TO
cord-350836-1enteev7	263	78	activate	activate	VB
cord-350836-1enteev7	263	79	RIG	rig	NN
cord-350836-1enteev7	263	80	-	-	:
cord-350836-1enteev7	263	81	I	i	NN
cord-350836-1enteev7	263	82	(	(	-LRB-
cord-350836-1enteev7	263	83	67	67	CD
cord-350836-1enteev7	263	84	)	)	-RRB-
cord-350836-1enteev7	263	85	,	,	,
cord-350836-1enteev7	263	86	which	which	WDT
cord-350836-1enteev7	263	87	has	have	VBZ
cord-350836-1enteev7	263	88	been	be	VBN
cord-350836-1enteev7	263	89	demonstrated	demonstrate	VBN
cord-350836-1enteev7	263	90	to	to	TO
cord-350836-1enteev7	263	91	occur	occur	VB
cord-350836-1enteev7	263	92	by	by	IN
cord-350836-1enteev7	263	93	preventing	prevent	VBG
cord-350836-1enteev7	263	94	RIG	rig	NN
cord-350836-1enteev7	263	95	-	-	:
cord-350836-1enteev7	263	96	I	-PRON-	PRP
cord-350836-1enteev7	263	97	filament	filament	NN
cord-350836-1enteev7	263	98	formation	formation	NN
cord-350836-1enteev7	263	99	in	in	IN
cord-350836-1enteev7	263	100	-	-	HYPH
cord-350836-1enteev7	263	101	situ	situ	NN
cord-350836-1enteev7	263	102	(	(	-LRB-
cord-350836-1enteev7	263	103	142	142	CD
cord-350836-1enteev7	263	104	)	)	-RRB-
cord-350836-1enteev7	263	105	.	.	.
cord-350836-1enteev7	264	1	N-6-methyladenosine	N-6-methyladenosine	NNP
cord-350836-1enteev7	265	1	(	(	-LRB-
cord-350836-1enteev7	265	2	m6A	m6a	NN
cord-350836-1enteev7	265	3	)	)	-RRB-
cord-350836-1enteev7	265	4	nucleotides	nucleotide	NNS
cord-350836-1enteev7	265	5	,	,	,
cord-350836-1enteev7	265	6	which	which	WDT
cord-350836-1enteev7	265	7	are	be	VBP
cord-350836-1enteev7	265	8	well	well	RB
cord-350836-1enteev7	265	9	-	-	HYPH
cord-350836-1enteev7	265	10	known	know	VBN
cord-350836-1enteev7	265	11	nucleotide	nucleotide	JJ
cord-350836-1enteev7	265	12	modifications	modification	NNS
cord-350836-1enteev7	265	13	among	among	IN
cord-350836-1enteev7	265	14	viruses	virus	NNS
cord-350836-1enteev7	265	15	(	(	-LRB-
cord-350836-1enteev7	265	16	235	235	CD
cord-350836-1enteev7	265	17	)	)	-RRB-
cord-350836-1enteev7	265	18	,	,	,
cord-350836-1enteev7	265	19	have	have	VBP
cord-350836-1enteev7	265	20	also	also	RB
cord-350836-1enteev7	265	21	been	be	VBN
cord-350836-1enteev7	265	22	found	find	VBN
cord-350836-1enteev7	265	23	to	to	TO
cord-350836-1enteev7	265	24	ablate	ablate	VB
cord-350836-1enteev7	265	25	dsRNA	dsrna	NN
cord-350836-1enteev7	265	26	binding	bind	VBG
cord-350836-1enteev7	265	27	to	to	IN
cord-350836-1enteev7	265	28	RIG	rig	NN
cord-350836-1enteev7	265	29	-	-	:
cord-350836-1enteev7	265	30	I	i	NN
cord-350836-1enteev7	265	31	(	(	-LRB-
cord-350836-1enteev7	265	32	236	236	CD
cord-350836-1enteev7	265	33	)	)	-RRB-
cord-350836-1enteev7	265	34	.	.	.
cord-350836-1enteev7	266	1	It	-PRON-	PRP
cord-350836-1enteev7	266	2	has	have	VBZ
cord-350836-1enteev7	266	3	been	be	VBN
cord-350836-1enteev7	266	4	demonstrated	demonstrate	VBN
cord-350836-1enteev7	266	5	that	that	IN
cord-350836-1enteev7	266	6	certain	certain	JJ
cord-350836-1enteev7	266	7	RNA	RNA	NNP
cord-350836-1enteev7	266	8	-	-	HYPH
cord-350836-1enteev7	266	9	DNA	dna	NN
cord-350836-1enteev7	266	10	hybrid	hybrid	NN
cord-350836-1enteev7	266	11	constructs	construct	NNS
cord-350836-1enteev7	266	12	with	with	IN
cord-350836-1enteev7	266	13	ribonucleotides	ribonucleotide	NNS
cord-350836-1enteev7	266	14	at	at	IN
cord-350836-1enteev7	266	15	positions	position	NNS
cord-350836-1enteev7	266	16	2	2	CD
cord-350836-1enteev7	266	17	and	and	CC
cord-350836-1enteev7	266	18	5	5	CD
cord-350836-1enteev7	266	19	of	of	IN
cord-350836-1enteev7	266	20	the	the	DT
cord-350836-1enteev7	266	21	DNA	dna	NN
cord-350836-1enteev7	266	22	strand	strand	NN
cord-350836-1enteev7	266	23	can	can	MD
cord-350836-1enteev7	266	24	bind	bind	VB
cord-350836-1enteev7	266	25	to	to	IN
cord-350836-1enteev7	266	26	RIG	rig	NN
cord-350836-1enteev7	266	27	-	-	:
cord-350836-1enteev7	266	28	I	-PRON-	PRP
cord-350836-1enteev7	266	29	and	and	CC
cord-350836-1enteev7	266	30	activate	activate	VB
cord-350836-1enteev7	266	31	its	-PRON-	PRP$
cord-350836-1enteev7	266	32	ATPase	ATPase	NNP
cord-350836-1enteev7	266	33	activity	activity	NN
cord-350836-1enteev7	266	34	(	(	-LRB-
cord-350836-1enteev7	266	35	75	75	CD
cord-350836-1enteev7	266	36	)	)	-RRB-
cord-350836-1enteev7	266	37	.	.	.
cord-350836-1enteev7	267	1	ATPase	ATPase	NNP
cord-350836-1enteev7	267	2	activity	activity	NN
cord-350836-1enteev7	267	3	is	be	VBZ
cord-350836-1enteev7	267	4	necessary	necessary	JJ
cord-350836-1enteev7	267	5	for	for	IN
cord-350836-1enteev7	267	6	full	full	JJ
cord-350836-1enteev7	267	7	activation	activation	NN
cord-350836-1enteev7	267	8	of	of	IN
cord-350836-1enteev7	267	9	RIG	rig	NN
cord-350836-1enteev7	267	10	-	-	:
cord-350836-1enteev7	267	11	I	i	NN
cord-350836-1enteev7	267	12	and	and	CC
cord-350836-1enteev7	267	13	expression	expression	NN
cord-350836-1enteev7	267	14	of	of	IN
cord-350836-1enteev7	267	15	IFNβ	IFNβ	NNS
cord-350836-1enteev7	267	16	(	(	-LRB-
cord-350836-1enteev7	267	17	75	75	CD
cord-350836-1enteev7	267	18	,	,	,
cord-350836-1enteev7	267	19	237	237	CD
cord-350836-1enteev7	267	20	)	)	-RRB-
cord-350836-1enteev7	267	21	,	,	,
cord-350836-1enteev7	267	22	so	so	CC
cord-350836-1enteev7	267	23	the	the	DT
cord-350836-1enteev7	267	24	minimum	minimum	JJ
cord-350836-1enteev7	267	25	requirement	requirement	NN
cord-350836-1enteev7	267	26	of	of	IN
cord-350836-1enteev7	267	27	a	a	DT
cord-350836-1enteev7	267	28	motif	motif	NN
cord-350836-1enteev7	267	29	not	not	RB
cord-350836-1enteev7	267	30	found	find	VBN
cord-350836-1enteev7	267	31	in	in	IN
cord-350836-1enteev7	267	32	host	host	NN
cord-350836-1enteev7	267	33	RNA	RNA	NNP
cord-350836-1enteev7	267	34	for	for	IN
cord-350836-1enteev7	267	35	ATPase	ATPase	NNP
cord-350836-1enteev7	267	36	activity	activity	NN
cord-350836-1enteev7	267	37	has	have	VBZ
cord-350836-1enteev7	267	38	significant	significant	JJ
cord-350836-1enteev7	267	39	implications	implication	NNS
cord-350836-1enteev7	267	40	for	for	IN
cord-350836-1enteev7	267	41	the	the	DT
cord-350836-1enteev7	267	42	distinction	distinction	NN
cord-350836-1enteev7	267	43	between	between	IN
cord-350836-1enteev7	267	44	self	self	NN
cord-350836-1enteev7	267	45	and	and	CC
cord-350836-1enteev7	267	46	non	non	JJ
cord-350836-1enteev7	267	47	-	-	JJ
cord-350836-1enteev7	267	48	self	self	JJ
cord-350836-1enteev7	267	49	RNAs	rna	NNS
cord-350836-1enteev7	267	50	.	.	.
cord-350836-1enteev7	268	1	Expanding	expand	VBG
cord-350836-1enteev7	268	2	on	on	IN
cord-350836-1enteev7	268	3	this	this	DT
cord-350836-1enteev7	268	4	observation	observation	NN
cord-350836-1enteev7	268	5	,	,	,
cord-350836-1enteev7	268	6	exogenous	exogenous	JJ
cord-350836-1enteev7	268	7	ATPase	ATPase	NNP
cord-350836-1enteev7	268	8	activity	activity	NN
cord-350836-1enteev7	268	9	may	may	MD
cord-350836-1enteev7	268	10	also	also	RB
cord-350836-1enteev7	268	11	be	be	VB
cord-350836-1enteev7	268	12	sufficient	sufficient	JJ
cord-350836-1enteev7	268	13	to	to	TO
cord-350836-1enteev7	268	14	potentiate	potentiate	VB
cord-350836-1enteev7	268	15	RIG	rig	NN
cord-350836-1enteev7	268	16	-	-	:
cord-350836-1enteev7	268	17	I	I	NNP
cord-350836-1enteev7	268	18	and	and	CC
cord-350836-1enteev7	268	19	MDA5	MDA5	NNP
cord-350836-1enteev7	268	20	,	,	,
cord-350836-1enteev7	268	21	as	as	IN
cord-350836-1enteev7	268	22	LGP2	LGP2	NNP
cord-350836-1enteev7	268	23	ATPase	ATPase	NNP
cord-350836-1enteev7	268	24	mutant	mutant	JJ
cord-350836-1enteev7	268	25	mice	mouse	NNS
cord-350836-1enteev7	268	26	are	be	VBP
cord-350836-1enteev7	268	27	significantly	significantly	RB
cord-350836-1enteev7	268	28	more	more	RBR
cord-350836-1enteev7	268	29	susceptible	susceptible	JJ
cord-350836-1enteev7	268	30	to	to	IN
cord-350836-1enteev7	268	31	viral	viral	JJ
cord-350836-1enteev7	268	32	infection	infection	NN
cord-350836-1enteev7	268	33	even	even	RB
cord-350836-1enteev7	268	34	in	in	IN
cord-350836-1enteev7	268	35	the	the	DT
cord-350836-1enteev7	268	36	presence	presence	NN
cord-350836-1enteev7	268	37	of	of	IN
cord-350836-1enteev7	268	38	functional	functional	JJ
cord-350836-1enteev7	268	39	RIG	rig	NN
cord-350836-1enteev7	268	40	-	-	:
cord-350836-1enteev7	268	41	I	I	NNP
cord-350836-1enteev7	268	42	and	and	CC
cord-350836-1enteev7	268	43	MDA5	MDA5	NNP
cord-350836-1enteev7	268	44	(	(	-LRB-
cord-350836-1enteev7	268	45	238	238	CD
cord-350836-1enteev7	268	46	)	)	-RRB-
cord-350836-1enteev7	268	47	.	.	.
cord-350836-1enteev7	269	1	However	however	RB
cord-350836-1enteev7	269	2	,	,	,
cord-350836-1enteev7	269	3	this	this	DT
cord-350836-1enteev7	269	4	model	model	NN
cord-350836-1enteev7	269	5	is	be	VBZ
cord-350836-1enteev7	269	6	further	far	RBR
cord-350836-1enteev7	269	7	complicated	complicate	VBN
cord-350836-1enteev7	269	8	by	by	IN
cord-350836-1enteev7	269	9	certain	certain	JJ
cord-350836-1enteev7	269	10	RNA	RNA	NNP
cord-350836-1enteev7	269	11	-	-	HYPH
cord-350836-1enteev7	269	12	DNA	dna	NN
cord-350836-1enteev7	269	13	hybrids	hybrid	NNS
cord-350836-1enteev7	269	14	that	that	WDT
cord-350836-1enteev7	269	15	are	be	VBP
cord-350836-1enteev7	269	16	able	able	JJ
cord-350836-1enteev7	269	17	to	to	TO
cord-350836-1enteev7	269	18	bind	bind	VB
cord-350836-1enteev7	269	19	RIG	rig	NN
cord-350836-1enteev7	269	20	-	-	:
cord-350836-1enteev7	269	21	I	-PRON-	PRP
cord-350836-1enteev7	269	22	and	and	CC
cord-350836-1enteev7	269	23	activate	activate	VB
cord-350836-1enteev7	269	24	ATPase	ATPase	NNP
cord-350836-1enteev7	269	25	activity	activity	NN
cord-350836-1enteev7	269	26	,	,	,
cord-350836-1enteev7	269	27	but	but	CC
cord-350836-1enteev7	269	28	do	do	VB
cord-350836-1enteev7	269	29	n't	not	RB
cord-350836-1enteev7	269	30	induce	induce	VB
cord-350836-1enteev7	269	31	IFNβ	IFNβ	NNS
cord-350836-1enteev7	269	32	expression	expression	NN
cord-350836-1enteev7	269	33	(	(	-LRB-
cord-350836-1enteev7	269	34	75	75	CD
cord-350836-1enteev7	269	35	)	)	-RRB-
cord-350836-1enteev7	269	36	.	.	.
cord-350836-1enteev7	270	1	It	-PRON-	PRP
cord-350836-1enteev7	270	2	is	be	VBZ
cord-350836-1enteev7	270	3	currently	currently	RB
cord-350836-1enteev7	270	4	undetermined	undetermined	JJ
cord-350836-1enteev7	270	5	whether	whether	IN
cord-350836-1enteev7	270	6	such	such	JJ
cord-350836-1enteev7	270	7	hybrids	hybrid	NNS
cord-350836-1enteev7	270	8	can	can	MD
cord-350836-1enteev7	270	9	sterically	sterically	RB
cord-350836-1enteev7	270	10	inhibit	inhibit	VB
cord-350836-1enteev7	270	11	RIG	rig	NN
cord-350836-1enteev7	270	12	-	-	:
cord-350836-1enteev7	270	13	I	-PRON-	PRP
cord-350836-1enteev7	270	14	due	due	IN
cord-350836-1enteev7	270	15	to	to	IN
cord-350836-1enteev7	270	16	the	the	DT
cord-350836-1enteev7	270	17	presence	presence	NN
cord-350836-1enteev7	270	18	of	of	IN
cord-350836-1enteev7	270	19	mostly	mostly	RB
cord-350836-1enteev7	270	20	dNTPs	dntps	CD
cord-350836-1enteev7	270	21	or	or	CC
cord-350836-1enteev7	270	22	whether	whether	IN
cord-350836-1enteev7	270	23	they	-PRON-	PRP
cord-350836-1enteev7	270	24	inhibit	inhibit	VBP
cord-350836-1enteev7	270	25	RIG-	rig-	PRP
cord-350836-1enteev7	271	1	I	-PRON-	PRP
cord-350836-1enteev7	271	2	in	in	IN
cord-350836-1enteev7	271	3	a	a	DT
cord-350836-1enteev7	271	4	yet	yet	RB
cord-350836-1enteev7	271	5	undescribed	undescribed	JJ
cord-350836-1enteev7	271	6	way	way	NN
cord-350836-1enteev7	271	7	.	.	.
cord-350836-1enteev7	272	1	Recent	recent	JJ
cord-350836-1enteev7	272	2	kinetic	kinetic	JJ
cord-350836-1enteev7	272	3	studies	study	NNS
cord-350836-1enteev7	272	4	of	of	IN
cord-350836-1enteev7	272	5	RIG	rig	NN
cord-350836-1enteev7	272	6	-	-	:
cord-350836-1enteev7	272	7	I	I	NNP
cord-350836-1enteev7	272	8	and	and	CC
cord-350836-1enteev7	272	9	MDA5	mda5	JJ
cord-350836-1enteev7	272	10	activation	activation	NN
cord-350836-1enteev7	272	11	by	by	IN
cord-350836-1enteev7	272	12	PAMP	PAMP	NNP
cord-350836-1enteev7	272	13	(	(	-LRB-
cord-350836-1enteev7	272	14	dsRNA	dsrna	NN
cord-350836-1enteev7	272	15	)	)	-RRB-
cord-350836-1enteev7	272	16	help	help	VBP
cord-350836-1enteev7	272	17	illustrate	illustrate	VB
cord-350836-1enteev7	272	18	how	how	WRB
cord-350836-1enteev7	272	19	ATPase	ATPase	NNP
cord-350836-1enteev7	272	20	activity	activity	NN
cord-350836-1enteev7	272	21	is	be	VBZ
cord-350836-1enteev7	272	22	critical	critical	JJ
cord-350836-1enteev7	272	23	for	for	IN
cord-350836-1enteev7	272	24	their	-PRON-	PRP$
cord-350836-1enteev7	272	25	function	function	NN
cord-350836-1enteev7	272	26	and	and	CC
cord-350836-1enteev7	272	27	distinction	distinction	NN
cord-350836-1enteev7	272	28	between	between	IN
cord-350836-1enteev7	272	29	host	host	NN
cord-350836-1enteev7	272	30	(	(	-LRB-
cord-350836-1enteev7	272	31	self	self	NN
cord-350836-1enteev7	272	32	)	)	-RRB-
cord-350836-1enteev7	272	33	and	and	CC
cord-350836-1enteev7	272	34	foreign	foreign	JJ
cord-350836-1enteev7	272	35	(	(	-LRB-
cord-350836-1enteev7	272	36	non	non	JJ
cord-350836-1enteev7	272	37	-	-	JJ
cord-350836-1enteev7	272	38	self	self	JJ
cord-350836-1enteev7	272	39	)	)	-RRB-
cord-350836-1enteev7	272	40	RNA	RNA	NNP
cord-350836-1enteev7	272	41	.	.	.
cord-350836-1enteev7	273	1	RIG	rig	NN
cord-350836-1enteev7	273	2	-	-	:
cord-350836-1enteev7	273	3	I	-PRON-	PRP
cord-350836-1enteev7	273	4	binding	bind	VBG
cord-350836-1enteev7	273	5	to	to	IN
cord-350836-1enteev7	273	6	ATP	ATP	NNP
cord-350836-1enteev7	273	7	is	be	VBZ
cord-350836-1enteev7	273	8	sufficient	sufficient	JJ
cord-350836-1enteev7	273	9	for	for	IN
cord-350836-1enteev7	273	10	interaction	interaction	NN
cord-350836-1enteev7	273	11	with	with	IN
cord-350836-1enteev7	273	12	dsRNA	dsRNA	NNS
cord-350836-1enteev7	273	13	(	(	-LRB-
cord-350836-1enteev7	273	14	144	144	CD
cord-350836-1enteev7	273	15	,	,	,
cord-350836-1enteev7	273	16	176	176	CD
cord-350836-1enteev7	273	17	)	)	-RRB-
cord-350836-1enteev7	273	18	.	.	.
cord-350836-1enteev7	274	1	RIG	rig	NN
cord-350836-1enteev7	274	2	-	-	:
cord-350836-1enteev7	274	3	I	-PRON-	PRP
cord-350836-1enteev7	274	4	ATPase	ATPase	NNP
cord-350836-1enteev7	274	5	activity	activity	NN
cord-350836-1enteev7	274	6	is	be	VBZ
cord-350836-1enteev7	274	7	inhibited	inhibit	VBN
cord-350836-1enteev7	274	8	in	in	IN
cord-350836-1enteev7	274	9	the	the	DT
cord-350836-1enteev7	274	10	absence	absence	NN
cord-350836-1enteev7	274	11	of	of	IN
cord-350836-1enteev7	274	12	PAMP	PAMP	NNP
cord-350836-1enteev7	274	13	(	(	-LRB-
cord-350836-1enteev7	274	14	dsRNA	dsrna	NN
cord-350836-1enteev7	274	15	)	)	-RRB-
cord-350836-1enteev7	274	16	by	by	IN
cord-350836-1enteev7	274	17	a	a	DT
cord-350836-1enteev7	274	18	helical	helical	JJ
cord-350836-1enteev7	274	19	arm	arm	NN
cord-350836-1enteev7	274	20	that	that	WDT
cord-350836-1enteev7	274	21	blocks	block	VBZ
cord-350836-1enteev7	274	22	the	the	DT
cord-350836-1enteev7	274	23	ATPase	ATPase	NNP
cord-350836-1enteev7	274	24	site	site	NN
cord-350836-1enteev7	274	25	(	(	-LRB-
cord-350836-1enteev7	274	26	239	239	CD
cord-350836-1enteev7	274	27	)	)	-RRB-
cord-350836-1enteev7	274	28	.	.	.
cord-350836-1enteev7	275	1	Upon	upon	IN
cord-350836-1enteev7	275	2	interaction	interaction	NN
cord-350836-1enteev7	275	3	with	with	IN
cord-350836-1enteev7	275	4	PAMP	PAMP	NNP
cord-350836-1enteev7	275	5	(	(	-LRB-
cord-350836-1enteev7	275	6	dsRNA	dsrna	NN
cord-350836-1enteev7	275	7	)	)	-RRB-
cord-350836-1enteev7	275	8	,	,	,
cord-350836-1enteev7	275	9	the	the	DT
cord-350836-1enteev7	275	10	helical	helical	JJ
cord-350836-1enteev7	275	11	arm	arm	NN
cord-350836-1enteev7	275	12	shifts	shift	NNS
cord-350836-1enteev7	275	13	and	and	CC
cord-350836-1enteev7	275	14	the	the	DT
cord-350836-1enteev7	275	15	two	two	CD
cord-350836-1enteev7	275	16	helicase	helicase	NN
cord-350836-1enteev7	275	17	domains	domain	NNS
cord-350836-1enteev7	275	18	are	be	VBP
cord-350836-1enteev7	275	19	brought	bring	VBN
cord-350836-1enteev7	275	20	together	together	RB
cord-350836-1enteev7	275	21	to	to	TO
cord-350836-1enteev7	275	22	form	form	VB
cord-350836-1enteev7	275	23	an	an	DT
cord-350836-1enteev7	275	24	active	active	JJ
cord-350836-1enteev7	275	25	ATPase	ATPase	NNP
cord-350836-1enteev7	275	26	site	site	NN
cord-350836-1enteev7	275	27	(	(	-LRB-
cord-350836-1enteev7	275	28	239	239	CD
cord-350836-1enteev7	275	29	)	)	-RRB-
cord-350836-1enteev7	275	30	.	.	.
cord-350836-1enteev7	276	1	RIG	rig	NN
cord-350836-1enteev7	276	2	-	-	:
cord-350836-1enteev7	276	3	I	-PRON-	PRP
cord-350836-1enteev7	276	4	then	then	RB
cord-350836-1enteev7	276	5	catalyzes	catalyze	VBZ
cord-350836-1enteev7	276	6	ATP	ATP	NNP
cord-350836-1enteev7	276	7	to	to	TO
cord-350836-1enteev7	276	8	break	break	VB
cord-350836-1enteev7	276	9	the	the	DT
cord-350836-1enteev7	276	10	5	5	CD
cord-350836-1enteev7	276	11	′	′	CD
cord-350836-1enteev7	276	12	ppp	ppp	NNP
cord-350836-1enteev7	276	13	dsRNA	dsrna	NN
cord-350836-1enteev7	276	14	interactions	interaction	NNS
cord-350836-1enteev7	276	15	within	within	IN
cord-350836-1enteev7	276	16	seconds	second	NNS
cord-350836-1enteev7	276	17	.	.	.
cord-350836-1enteev7	277	1	ATP	ATP	NNP
cord-350836-1enteev7	277	2	is	be	VBZ
cord-350836-1enteev7	277	3	then	then	RB
cord-350836-1enteev7	277	4	rapidly	rapidly	RB
cord-350836-1enteev7	277	5	hydrolyzed	hydrolyze	VBN
cord-350836-1enteev7	277	6	to	to	TO
cord-350836-1enteev7	277	7	facilitate	facilitate	VB
cord-350836-1enteev7	277	8	translocation	translocation	NN
cord-350836-1enteev7	277	9	of	of	IN
cord-350836-1enteev7	277	10	RIG	rig	NN
cord-350836-1enteev7	278	1	-I	-I	:
cord-350836-1enteev7	278	2	to	to	IN
cord-350836-1enteev7	278	3	the	the	DT
cord-350836-1enteev7	278	4	opposite	opposite	JJ
cord-350836-1enteev7	278	5	dsRNA	dsrna	JJ
cord-350836-1enteev7	278	6	end	end	NN
cord-350836-1enteev7	278	7	,	,	,
cord-350836-1enteev7	278	8	after	after	IN
cord-350836-1enteev7	278	9	which	which	WDT
cord-350836-1enteev7	278	10	the	the	DT
cord-350836-1enteev7	278	11	RIG	rig	NN
cord-350836-1enteev7	278	12	-	-	HYPH
cord-350836-1enteev7	278	13	I	-PRON-	PRP
cord-350836-1enteev7	278	14	oligomers	oligomer	NNS
cord-350836-1enteev7	278	15	can	can	MD
cord-350836-1enteev7	278	16	form	form	VB
cord-350836-1enteev7	278	17	(	(	-LRB-
cord-350836-1enteev7	278	18	144	144	CD
cord-350836-1enteev7	278	19	)	)	-RRB-
cord-350836-1enteev7	278	20	.	.	.
cord-350836-1enteev7	279	1	On	on	IN
cord-350836-1enteev7	279	2	the	the	DT
cord-350836-1enteev7	279	3	other	other	JJ
cord-350836-1enteev7	279	4	hand	hand	NN
cord-350836-1enteev7	279	5	,	,	,
cord-350836-1enteev7	279	6	ATP	ATP	NNP
cord-350836-1enteev7	279	7	hydrolysis	hydrolysis	NN
cord-350836-1enteev7	279	8	drives	drive	VBZ
cord-350836-1enteev7	279	9	rapid	rapid	JJ
cord-350836-1enteev7	279	10	disassociation	disassociation	NN
cord-350836-1enteev7	279	11	of	of	IN
cord-350836-1enteev7	279	12	RIG	rig	NN
cord-350836-1enteev7	279	13	-	-	:
cord-350836-1enteev7	279	14	I	-PRON-	PRP
cord-350836-1enteev7	279	15	from	from	IN
cord-350836-1enteev7	279	16	host	host	NN
cord-350836-1enteev7	279	17	RNA	RNA	NNP
cord-350836-1enteev7	279	18	features	feature	NNS
cord-350836-1enteev7	279	19	.	.	.
cord-350836-1enteev7	280	1	These	these	DT
cord-350836-1enteev7	280	2	features	feature	NNS
cord-350836-1enteev7	280	3	include	include	VBP
cord-350836-1enteev7	280	4	dsRNA	dsRNA	VBG
cord-350836-1enteev7	280	5	with	with	IN
cord-350836-1enteev7	280	6	a	a	DT
cord-350836-1enteev7	280	7	5	5	CD
cord-350836-1enteev7	280	8	′	′	CD
cord-350836-1enteev7	280	9	monophosphate	monophosphate	NN
cord-350836-1enteev7	280	10	group	group	NN
cord-350836-1enteev7	280	11	(	(	-LRB-
cord-350836-1enteev7	280	12	174	174	CD
cord-350836-1enteev7	280	13	,	,	,
cord-350836-1enteev7	280	14	175	175	CD
cord-350836-1enteev7	280	15	)	)	-RRB-
cord-350836-1enteev7	280	16	that	that	WDT
cord-350836-1enteev7	280	17	is	be	VBZ
cord-350836-1enteev7	280	18	found	find	VBN
cord-350836-1enteev7	280	19	in	in	IN
cord-350836-1enteev7	280	20	mRNA	mrna	NN
cord-350836-1enteev7	280	21	after	after	IN
cord-350836-1enteev7	280	22	decapping	decapping	NN
cord-350836-1enteev7	280	23	during	during	IN
cord-350836-1enteev7	280	24	the	the	DT
cord-350836-1enteev7	280	25	mRNA	mRNA	NNP
cord-350836-1enteev7	280	26	degradation	degradation	NN
cord-350836-1enteev7	280	27	process	process	NN
cord-350836-1enteev7	280	28	(	(	-LRB-
cord-350836-1enteev7	280	29	177	177	CD
cord-350836-1enteev7	280	30	)	)	-RRB-
cord-350836-1enteev7	280	31	and	and	CC
cord-350836-1enteev7	280	32	3	3	CD
cord-350836-1enteev7	280	33	′	′	CD
cord-350836-1enteev7	280	34	overhang	overhang	NN
cord-350836-1enteev7	280	35	RNA	RNA	NNP
cord-350836-1enteev7	280	36	(	(	-LRB-
cord-350836-1enteev7	280	37	144	144	CD
cord-350836-1enteev7	280	38	,	,	,
cord-350836-1enteev7	280	39	170	170	CD
cord-350836-1enteev7	280	40	)	)	-RRB-
cord-350836-1enteev7	280	41	found	find	VBD
cord-350836-1enteev7	280	42	in	in	IN
cord-350836-1enteev7	280	43	miRNA	miRNA	NNP
cord-350836-1enteev7	280	44	(	(	-LRB-
cord-350836-1enteev7	280	45	240	240	CD
cord-350836-1enteev7	280	46	)	)	-RRB-
cord-350836-1enteev7	280	47	as	as	RB
cord-350836-1enteev7	280	48	well	well	RB
cord-350836-1enteev7	280	49	as	as	IN
cord-350836-1enteev7	280	50	other	other	JJ
cord-350836-1enteev7	280	51	RNA	RNA	NNP
cord-350836-1enteev7	280	52	motifs	motif	NNS
cord-350836-1enteev7	280	53	,	,	,
cord-350836-1enteev7	280	54	such	such	JJ
cord-350836-1enteev7	280	55	as	as	IN
cord-350836-1enteev7	280	56	5	5	CD
cord-350836-1enteev7	280	57	′	′	CD
cord-350836-1enteev7	280	58	OH	OH	NNP
cord-350836-1enteev7	280	59	RNA	RNA	NNP
cord-350836-1enteev7	280	60	(	(	-LRB-
cord-350836-1enteev7	280	61	144	144	CD
cord-350836-1enteev7	280	62	,	,	,
cord-350836-1enteev7	280	63	176	176	CD
cord-350836-1enteev7	280	64	)	)	-RRB-
cord-350836-1enteev7	280	65	found	find	VBD
cord-350836-1enteev7	280	66	in	in	IN
cord-350836-1enteev7	280	67	bacteria	bacteria	NNS
cord-350836-1enteev7	280	68	(	(	-LRB-
cord-350836-1enteev7	280	69	241	241	CD
cord-350836-1enteev7	280	70	)	)	-RRB-
cord-350836-1enteev7	280	71	.	.	.
cord-350836-1enteev7	281	1	Furthermore	furthermore	RB
cord-350836-1enteev7	281	2	,	,	,
cord-350836-1enteev7	281	3	an	an	DT
cord-350836-1enteev7	281	4	impaired	impaired	JJ
cord-350836-1enteev7	281	5	ATPase	ATPase	NNP
cord-350836-1enteev7	281	6	functionality	functionality	NN
cord-350836-1enteev7	281	7	increases	increase	VBZ
cord-350836-1enteev7	281	8	the	the	DT
cord-350836-1enteev7	281	9	promiscuity	promiscuity	NN
cord-350836-1enteev7	281	10	of	of	IN
cord-350836-1enteev7	281	11	RIG	rig	NN
cord-350836-1enteev7	281	12	-	-	:
cord-350836-1enteev7	281	13	I	-PRON-	PRP
cord-350836-1enteev7	281	14	binding	bind	VBG
cord-350836-1enteev7	281	15	these	these	DT
cord-350836-1enteev7	281	16	host	host	NN
cord-350836-1enteev7	281	17	RNA	RNA	NNP
cord-350836-1enteev7	281	18	motifs	motif	NNS
cord-350836-1enteev7	281	19	(	(	-LRB-
cord-350836-1enteev7	281	20	144	144	CD
cord-350836-1enteev7	281	21	,	,	,
cord-350836-1enteev7	281	22	176	176	CD
cord-350836-1enteev7	281	23	,	,	,
cord-350836-1enteev7	281	24	242	242	CD
cord-350836-1enteev7	281	25	)	)	-RRB-
cord-350836-1enteev7	281	26	.	.	.
cord-350836-1enteev7	282	1	Similar	similar	JJ
cord-350836-1enteev7	282	2	ATPase	ATPase	NNP
cord-350836-1enteev7	282	3	functions	function	NNS
cord-350836-1enteev7	282	4	have	have	VBP
cord-350836-1enteev7	282	5	been	be	VBN
cord-350836-1enteev7	282	6	found	find	VBN
cord-350836-1enteev7	282	7	during	during	IN
cord-350836-1enteev7	282	8	MDA5	mda5	JJ
cord-350836-1enteev7	282	9	filamentous	filamentous	JJ
cord-350836-1enteev7	282	10	formation	formation	NN
cord-350836-1enteev7	282	11	.	.	.
cord-350836-1enteev7	283	1	The	the	DT
cord-350836-1enteev7	283	2	C	C	NNP
cord-350836-1enteev7	283	3	terminus	terminus	NN
cord-350836-1enteev7	283	4	of	of	IN
cord-350836-1enteev7	283	5	MDA5	MDA5	NNP
cord-350836-1enteev7	283	6	is	be	VBZ
cord-350836-1enteev7	283	7	critical	critical	JJ
cord-350836-1enteev7	283	8	to	to	TO
cord-350836-1enteev7	283	9	form	form	VB
cord-350836-1enteev7	283	10	organized	organize	VBN
cord-350836-1enteev7	283	11	helical	helical	JJ
cord-350836-1enteev7	283	12	filaments	filament	NNS
cord-350836-1enteev7	283	13	(	(	-LRB-
cord-350836-1enteev7	283	14	138	138	CD
cord-350836-1enteev7	283	15	)	)	-RRB-
cord-350836-1enteev7	283	16	and	and	CC
cord-350836-1enteev7	283	17	ATP	ATP	NNP
cord-350836-1enteev7	283	18	binding	binding	NN
cord-350836-1enteev7	283	19	drives	drives	NNP
cord-350836-1enteev7	283	20	association	association	NN
cord-350836-1enteev7	283	21	and	and	CC
cord-350836-1enteev7	283	22	hydrolysis	hydrolysis	NN
cord-350836-1enteev7	283	23	and	and	CC
cord-350836-1enteev7	283	24	disassociation	disassociation	NN
cord-350836-1enteev7	283	25	from	from	IN
cord-350836-1enteev7	283	26	foreign	foreign	JJ
cord-350836-1enteev7	283	27	dsRNA	dsRNA	NNS
cord-350836-1enteev7	283	28	[	[	-LRB-
cord-350836-1enteev7	283	29	with	with	IN
cord-350836-1enteev7	283	30	little	little	JJ
cord-350836-1enteev7	283	31	coordination	coordination	NN
cord-350836-1enteev7	283	32	being	be	VBG
cord-350836-1enteev7	283	33	observed	observe	VBN
cord-350836-1enteev7	283	34	between	between	IN
cord-350836-1enteev7	283	35	neighboring	neighbor	VBG
cord-350836-1enteev7	283	36	MDA5	mda5	JJ
cord-350836-1enteev7	283	37	proteins	protein	NNS
cord-350836-1enteev7	283	38	(	(	-LRB-
cord-350836-1enteev7	283	39	137	137	CD
cord-350836-1enteev7	283	40	)	)	-RRB-
cord-350836-1enteev7	283	41	]	]	-RRB-
cord-350836-1enteev7	283	42	in	in	IN
cord-350836-1enteev7	283	43	a	a	DT
cord-350836-1enteev7	283	44	manner	manner	NN
cord-350836-1enteev7	283	45	that	that	WDT
cord-350836-1enteev7	283	46	involves	involve	VBZ
cord-350836-1enteev7	283	47	MDA5	MDA5	NNP
cord-350836-1enteev7	283	48	twisting	twist	VBG
cord-350836-1enteev7	283	49	along	along	IN
cord-350836-1enteev7	283	50	its	-PRON-	PRP$
cord-350836-1enteev7	283	51	flexible	flexible	JJ
cord-350836-1enteev7	283	52	and	and	CC
cord-350836-1enteev7	283	53	hydrophobic	hydrophobic	JJ
cord-350836-1enteev7	283	54	interface	interface	NN
cord-350836-1enteev7	283	55	domains	domain	NNS
cord-350836-1enteev7	283	56	(	(	-LRB-
cord-350836-1enteev7	283	57	243	243	CD
cord-350836-1enteev7	283	58	)	)	-RRB-
cord-350836-1enteev7	283	59	.	.	.
cord-350836-1enteev7	284	1	Taken	take	VBN
cord-350836-1enteev7	284	2	together	together	RB
cord-350836-1enteev7	284	3	,	,	,
cord-350836-1enteev7	284	4	ATPase	ATPase	NNP
cord-350836-1enteev7	284	5	activity	activity	NN
cord-350836-1enteev7	284	6	may	may	MD
cord-350836-1enteev7	284	7	be	be	VB
cord-350836-1enteev7	284	8	directed	direct	VBN
cord-350836-1enteev7	284	9	toward	toward	IN
cord-350836-1enteev7	284	10	rapid	rapid	JJ
cord-350836-1enteev7	284	11	disassociation	disassociation	NN
cord-350836-1enteev7	284	12	from	from	IN
cord-350836-1enteev7	284	13	host	host	NN
cord-350836-1enteev7	284	14	dsRNA	dsrna	NN
cord-350836-1enteev7	284	15	and	and	CC
cord-350836-1enteev7	284	16	degradation	degradation	NN
cord-350836-1enteev7	284	17	of	of	IN
cord-350836-1enteev7	284	18	RNA	RNA	NNP
cord-350836-1enteev7	284	19	-	-	HYPH
cord-350836-1enteev7	284	20	DNA	dna	NN
cord-350836-1enteev7	284	21	hybrids	hybrid	NNS
cord-350836-1enteev7	284	22	,	,	,
cord-350836-1enteev7	284	23	but	but	CC
cord-350836-1enteev7	284	24	primarily	primarily	RB
cord-350836-1enteev7	284	25	act	act	VB
cord-350836-1enteev7	284	26	on	on	IN
cord-350836-1enteev7	284	27	the	the	DT
cord-350836-1enteev7	284	28	translocation	translocation	NN
cord-350836-1enteev7	284	29	pathway	pathway	NN
cord-350836-1enteev7	284	30	upon	upon	IN
cord-350836-1enteev7	284	31	interaction	interaction	NN
cord-350836-1enteev7	284	32	with	with	IN
cord-350836-1enteev7	284	33	PAMP	PAMP	NNP
cord-350836-1enteev7	284	34	(	(	-LRB-
cord-350836-1enteev7	284	35	dsRNA	dsrna	NN
cord-350836-1enteev7	284	36	)	)	-RRB-
cord-350836-1enteev7	284	37	.	.	.
cord-350836-1enteev7	285	1	It	-PRON-	PRP
cord-350836-1enteev7	285	2	is	be	VBZ
cord-350836-1enteev7	285	3	also	also	RB
cord-350836-1enteev7	285	4	possible	possible	JJ
cord-350836-1enteev7	285	5	that	that	IN
cord-350836-1enteev7	285	6	host	host	NN
cord-350836-1enteev7	285	7	and	and	CC
cord-350836-1enteev7	285	8	hybrid	hybrid	NN
cord-350836-1enteev7	285	9	dsRNAs	dsRNAs	NNP
cord-350836-1enteev7	285	10	could	could	MD
cord-350836-1enteev7	285	11	inactivate	inactivate	VB
cord-350836-1enteev7	285	12	RIG-	RIG-	NNP
cord-350836-1enteev7	286	1	I	-PRON-	PRP
cord-350836-1enteev7	286	2	independently	independently	RB
cord-350836-1enteev7	286	3	of	of	IN
cord-350836-1enteev7	286	4	their	-PRON-	PRP$
cord-350836-1enteev7	286	5	ability	ability	NN
cord-350836-1enteev7	286	6	to	to	TO
cord-350836-1enteev7	286	7	bind	bind	VB
cord-350836-1enteev7	286	8	the	the	DT
cord-350836-1enteev7	286	9	C	c	NN
cord-350836-1enteev7	286	10	-	-	HYPH
cord-350836-1enteev7	286	11	terminus	terminus	NN
cord-350836-1enteev7	286	12	and	and	CC
cord-350836-1enteev7	286	13	activate	activate	VB
cord-350836-1enteev7	286	14	ATPase	ATPase	NNP
cord-350836-1enteev7	286	15	activity	activity	NN
cord-350836-1enteev7	286	16	.	.	.
cord-350836-1enteev7	287	1	This	this	DT
cord-350836-1enteev7	287	2	has	have	VBZ
cord-350836-1enteev7	287	3	been	be	VBN
cord-350836-1enteev7	287	4	shown	show	VBN
cord-350836-1enteev7	287	5	,	,	,
cord-350836-1enteev7	287	6	for	for	IN
cord-350836-1enteev7	287	7	example	example	NN
cord-350836-1enteev7	287	8	,	,	,
cord-350836-1enteev7	287	9	for	for	IN
cord-350836-1enteev7	287	10	a	a	DT
cord-350836-1enteev7	287	11	hybrid	hybrid	JJ
cord-350836-1enteev7	287	12	RNA	rna	NN
cord-350836-1enteev7	287	13	that	that	WDT
cord-350836-1enteev7	287	14	has	have	VBZ
cord-350836-1enteev7	287	15	one	one	CD
cord-350836-1enteev7	287	16	strand	strand	NN
cord-350836-1enteev7	287	17	consists	consist	VBZ
cord-350836-1enteev7	287	18	mostly	mostly	RB
cord-350836-1enteev7	287	19	of	of	IN
cord-350836-1enteev7	287	20	DNA	DNA	NNP
cord-350836-1enteev7	287	21	except	except	IN
cord-350836-1enteev7	287	22	at	at	IN
cord-350836-1enteev7	287	23	positions	position	NNS
cord-350836-1enteev7	287	24	2	2	CD
cord-350836-1enteev7	287	25	and	and	CC
cord-350836-1enteev7	287	26	5	5	CD
cord-350836-1enteev7	287	27	,	,	,
cord-350836-1enteev7	287	28	which	which	WDT
cord-350836-1enteev7	287	29	appears	appear	VBZ
cord-350836-1enteev7	287	30	to	to	TO
cord-350836-1enteev7	287	31	bind	bind	VB
cord-350836-1enteev7	287	32	RIG	rig	NN
cord-350836-1enteev7	287	33	-	-	:
cord-350836-1enteev7	287	34	I	-PRON-	PRP
cord-350836-1enteev7	287	35	and	and	CC
cord-350836-1enteev7	287	36	activate	activate	VB
cord-350836-1enteev7	287	37	its	-PRON-	PRP$
cord-350836-1enteev7	287	38	ATPase	ATPase	NNP
cord-350836-1enteev7	287	39	activity	activity	NN
cord-350836-1enteev7	287	40	but	but	CC
cord-350836-1enteev7	287	41	does	do	VBZ
cord-350836-1enteev7	287	42	n't	not	RB
cord-350836-1enteev7	287	43	activate	activate	VB
cord-350836-1enteev7	287	44	IFN1	IFN1	NNP
cord-350836-1enteev7	287	45	signaling	signal	VBG
cord-350836-1enteev7	287	46	(	(	-LRB-
cord-350836-1enteev7	287	47	75	75	CD
cord-350836-1enteev7	287	48	)	)	-RRB-
cord-350836-1enteev7	287	49	.	.	.
cord-350836-1enteev7	288	1	Future	future	JJ
cord-350836-1enteev7	288	2	studies	study	NNS
cord-350836-1enteev7	288	3	are	be	VBP
cord-350836-1enteev7	288	4	needed	need	VBN
cord-350836-1enteev7	288	5	in	in	IN
cord-350836-1enteev7	288	6	order	order	NN
cord-350836-1enteev7	288	7	to	to	TO
cord-350836-1enteev7	288	8	determine	determine	VB
cord-350836-1enteev7	288	9	these	these	DT
cord-350836-1enteev7	288	10	differential	differential	JJ
cord-350836-1enteev7	288	11	interaction	interaction	NN
cord-350836-1enteev7	288	12	mechanisms	mechanism	NNS
cord-350836-1enteev7	288	13	.	.	.
cord-350836-1enteev7	289	1	Contrary	contrary	JJ
cord-350836-1enteev7	289	2	to	to	IN
cord-350836-1enteev7	289	3	the	the	DT
cord-350836-1enteev7	289	4	traditional	traditional	JJ
cord-350836-1enteev7	289	5	paradigm	paradigm	NN
cord-350836-1enteev7	289	6	,	,	,
cord-350836-1enteev7	289	7	there	there	EX
cord-350836-1enteev7	289	8	is	be	VBZ
cord-350836-1enteev7	289	9	increasing	increase	VBG
cord-350836-1enteev7	289	10	evidence	evidence	NN
cord-350836-1enteev7	289	11	to	to	TO
cord-350836-1enteev7	289	12	suggest	suggest	VB
cord-350836-1enteev7	289	13	that	that	IN
cord-350836-1enteev7	289	14	RIG	rig	NN
cord-350836-1enteev7	289	15	-	-	:
cord-350836-1enteev7	289	16	I	I	NNP
cord-350836-1enteev7	289	17	and	and	CC
cord-350836-1enteev7	289	18	MDA5	MDA5	NNP
cord-350836-1enteev7	289	19	interact	interact	VBP
cord-350836-1enteev7	289	20	with	with	IN
cord-350836-1enteev7	289	21	certain	certain	JJ
cord-350836-1enteev7	289	22	host	host	NN
cord-350836-1enteev7	289	23	RNA	RNA	NNP
cord-350836-1enteev7	289	24	motifs	motif	NNS
cord-350836-1enteev7	289	25	,	,	,
cord-350836-1enteev7	289	26	resulting	result	VBG
cord-350836-1enteev7	289	27	in	in	IN
cord-350836-1enteev7	289	28	auto	auto	NN
cord-350836-1enteev7	289	29	-	-	HYPH
cord-350836-1enteev7	289	30	activation	activation	NN
cord-350836-1enteev7	289	31	or	or	CC
cord-350836-1enteev7	289	32	auto	auto	NN
cord-350836-1enteev7	289	33	-	-	HYPH
cord-350836-1enteev7	289	34	inhibition	inhibition	NN
cord-350836-1enteev7	289	35	of	of	IN
cord-350836-1enteev7	289	36	the	the	DT
cord-350836-1enteev7	289	37	IRF	IRF	NNP
cord-350836-1enteev7	289	38	pathway	pathway	NN
cord-350836-1enteev7	289	39	(	(	-LRB-
cord-350836-1enteev7	289	40	Figure	figure	NN
cord-350836-1enteev7	289	41	5	5	CD
cord-350836-1enteev7	289	42	)	)	-RRB-
cord-350836-1enteev7	289	43	.	.	.
cord-350836-1enteev7	290	1	One	one	CD
cord-350836-1enteev7	290	2	of	of	IN
cord-350836-1enteev7	290	3	the	the	DT
cord-350836-1enteev7	290	4	most	most	RBS
cord-350836-1enteev7	290	5	strongly	strongly	RB
cord-350836-1enteev7	290	6	supported	support	VBN
cord-350836-1enteev7	290	7	models	model	NNS
cord-350836-1enteev7	290	8	is	be	VBZ
cord-350836-1enteev7	290	9	activation	activation	NN
cord-350836-1enteev7	290	10	by	by	IN
cord-350836-1enteev7	290	11	host	host	NN
cord-350836-1enteev7	290	12	and	and	CC
cord-350836-1enteev7	290	13	viral	viral	JJ
cord-350836-1enteev7	290	14	circular	circular	JJ
cord-350836-1enteev7	290	15	RNAs	rna	NNS
cord-350836-1enteev7	290	16	(	(	-LRB-
cord-350836-1enteev7	290	17	circRNA	circRNA	NNP
cord-350836-1enteev7	290	18	)	)	-RRB-
cord-350836-1enteev7	290	19	.	.	.
cord-350836-1enteev7	291	1	Originally	originally	RB
cord-350836-1enteev7	291	2	found	find	VBN
cord-350836-1enteev7	291	3	in	in	IN
cord-350836-1enteev7	291	4	a	a	DT
cord-350836-1enteev7	291	5	variety	variety	NN
cord-350836-1enteev7	291	6	of	of	IN
cord-350836-1enteev7	291	7	pathogen	pathogen	NN
cord-350836-1enteev7	291	8	genomes	genome	NNS
cord-350836-1enteev7	291	9	,	,	,
cord-350836-1enteev7	291	10	circRNAs	circrna	VBN
cord-350836-1enteev7	291	11	in	in	IN
cord-350836-1enteev7	291	12	eukaryotic	eukaryotic	JJ
cord-350836-1enteev7	291	13	cells	cell	NNS
cord-350836-1enteev7	291	14	were	be	VBD
cord-350836-1enteev7	291	15	first	first	RB
cord-350836-1enteev7	291	16	thought	think	VBN
cord-350836-1enteev7	291	17	to	to	TO
cord-350836-1enteev7	291	18	be	be	VB
cord-350836-1enteev7	291	19	byproducts	byproduct	NNS
cord-350836-1enteev7	291	20	of	of	IN
cord-350836-1enteev7	291	21	the	the	DT
cord-350836-1enteev7	291	22	pre	pre	JJ
cord-350836-1enteev7	291	23	-	-	JJ
cord-350836-1enteev7	291	24	mRNA	mrna	JJ
cord-350836-1enteev7	291	25	splicing	splicing	NN
cord-350836-1enteev7	291	26	process	process	NN
cord-350836-1enteev7	291	27	.	.	.
cord-350836-1enteev7	292	1	However	however	RB
cord-350836-1enteev7	292	2	,	,	,
cord-350836-1enteev7	292	3	they	-PRON-	PRP
cord-350836-1enteev7	292	4	have	have	VBP
cord-350836-1enteev7	292	5	later	later	RB
cord-350836-1enteev7	292	6	been	be	VBN
cord-350836-1enteev7	292	7	found	find	VBN
cord-350836-1enteev7	292	8	to	to	TO
cord-350836-1enteev7	292	9	be	be	VB
cord-350836-1enteev7	292	10	produced	produce	VBN
cord-350836-1enteev7	292	11	by	by	IN
cord-350836-1enteev7	292	12	a	a	DT
cord-350836-1enteev7	292	13	non	non	JJ
cord-350836-1enteev7	292	14	-	-	JJ
cord-350836-1enteev7	292	15	canonical	canonical	JJ
cord-350836-1enteev7	292	16	"	"	``
cord-350836-1enteev7	292	17	backsplicing	backsplicing	NN
cord-350836-1enteev7	292	18	"	"	''
cord-350836-1enteev7	292	19	process	process	NN
cord-350836-1enteev7	292	20	and	and	CC
cord-350836-1enteev7	292	21	there	there	EX
cord-350836-1enteev7	292	22	is	be	VBZ
cord-350836-1enteev7	292	23	increasing	increase	VBG
cord-350836-1enteev7	292	24	evidence	evidence	NN
cord-350836-1enteev7	292	25	to	to	TO
cord-350836-1enteev7	292	26	suggest	suggest	VB
cord-350836-1enteev7	292	27	that	that	IN
cord-350836-1enteev7	292	28	they	-PRON-	PRP
cord-350836-1enteev7	292	29	play	play	VBP
cord-350836-1enteev7	292	30	some	some	DT
cord-350836-1enteev7	292	31	important	important	JJ
cord-350836-1enteev7	292	32	regulatory	regulatory	JJ
cord-350836-1enteev7	292	33	roles	role	NNS
cord-350836-1enteev7	292	34	(	(	-LRB-
cord-350836-1enteev7	292	35	244	244	CD
cord-350836-1enteev7	292	36	)	)	-RRB-
cord-350836-1enteev7	292	37	,	,	,
cord-350836-1enteev7	292	38	suggesting	suggest	VBG
cord-350836-1enteev7	292	39	that	that	IN
cord-350836-1enteev7	292	40	they	-PRON-	PRP
cord-350836-1enteev7	292	41	may	may	MD
cord-350836-1enteev7	292	42	have	have	VB
cord-350836-1enteev7	292	43	specifically	specifically	RB
cord-350836-1enteev7	292	44	evolved	evolve	VBN
cord-350836-1enteev7	292	45	for	for	IN
cord-350836-1enteev7	292	46	this	this	DT
cord-350836-1enteev7	292	47	purpose	purpose	NN
cord-350836-1enteev7	292	48	.	.	.
cord-350836-1enteev7	293	1	RIG	rig	NN
cord-350836-1enteev7	293	2	-	-	:
cord-350836-1enteev7	293	3	I	-PRON-	PRP
cord-350836-1enteev7	293	4	was	be	VBD
cord-350836-1enteev7	293	5	first	first	RB
cord-350836-1enteev7	293	6	found	find	VBN
cord-350836-1enteev7	293	7	to	to	TO
cord-350836-1enteev7	293	8	interact	interact	VB
cord-350836-1enteev7	293	9	with	with	IN
cord-350836-1enteev7	293	10	circRNA	circRNA	NNP
cord-350836-1enteev7	293	11	produced	produce	VBN
cord-350836-1enteev7	293	12	in	in	IN
cord-350836-1enteev7	293	13	situ	situ	NN
cord-350836-1enteev7	293	14	(	(	-LRB-
cord-350836-1enteev7	293	15	245	245	CD
cord-350836-1enteev7	293	16	)	)	-RRB-
cord-350836-1enteev7	293	17	.	.	.
cord-350836-1enteev7	294	1	Interestingly	interestingly	RB
cord-350836-1enteev7	294	2	,	,	,
cord-350836-1enteev7	294	3	the	the	DT
cord-350836-1enteev7	294	4	minimum	minimum	JJ
cord-350836-1enteev7	294	5	component	component	NN
cord-350836-1enteev7	294	6	required	require	VBN
cord-350836-1enteev7	294	7	for	for	IN
cord-350836-1enteev7	294	8	RIG	rig	NN
cord-350836-1enteev7	294	9	-	-	:
cord-350836-1enteev7	294	10	I	-PRON-	PRP
cord-350836-1enteev7	294	11	activation	activation	NN
cord-350836-1enteev7	294	12	is	be	VBZ
cord-350836-1enteev7	294	13	an	an	DT
cord-350836-1enteev7	294	14	intron	intron	NN
cord-350836-1enteev7	294	15	of	of	IN
cord-350836-1enteev7	294	16	pathogenic	pathogenic	JJ
cord-350836-1enteev7	294	17	origin	origin	NN
cord-350836-1enteev7	294	18	to	to	TO
cord-350836-1enteev7	294	19	be	be	VB
cord-350836-1enteev7	294	20	spliced	splice	VBN
cord-350836-1enteev7	294	21	out	out	RP
cord-350836-1enteev7	294	22	during	during	IN
cord-350836-1enteev7	294	23	the	the	DT
cord-350836-1enteev7	294	24	circularization	circularization	NN
cord-350836-1enteev7	294	25	process	process	NN
cord-350836-1enteev7	294	26	.	.	.
cord-350836-1enteev7	295	1	As	as	IN
cord-350836-1enteev7	295	2	human	human	JJ
cord-350836-1enteev7	295	3	introns	intron	NNS
cord-350836-1enteev7	295	4	have	have	VBP
cord-350836-1enteev7	295	5	been	be	VBN
cord-350836-1enteev7	295	6	found	find	VBN
cord-350836-1enteev7	295	7	to	to	TO
cord-350836-1enteev7	295	8	be	be	VB
cord-350836-1enteev7	295	9	associated	associate	VBN
cord-350836-1enteev7	295	10	with	with	IN
cord-350836-1enteev7	295	11	many	many	JJ
cord-350836-1enteev7	295	12	RNA	RNA	NNP
cord-350836-1enteev7	295	13	binding	bind	VBG
cord-350836-1enteev7	295	14	proteins	protein	NNS
cord-350836-1enteev7	295	15	,	,	,
cord-350836-1enteev7	295	16	it	-PRON-	PRP
cord-350836-1enteev7	295	17	is	be	VBZ
cord-350836-1enteev7	295	18	speculated	speculate	VBN
cord-350836-1enteev7	295	19	that	that	IN
cord-350836-1enteev7	295	20	these	these	DT
cord-350836-1enteev7	295	21	proteins	protein	NNS
cord-350836-1enteev7	295	22	may	may	MD
cord-350836-1enteev7	295	23	have	have	VB
cord-350836-1enteev7	295	24	prevented	prevent	VBN
cord-350836-1enteev7	295	25	circularization	circularization	NN
cord-350836-1enteev7	295	26	of	of	IN
cord-350836-1enteev7	295	27	this	this	DT
cord-350836-1enteev7	295	28	particular	particular	JJ
cord-350836-1enteev7	295	29	synthetic	synthetic	JJ
cord-350836-1enteev7	295	30	circRNA	circrna	NN
cord-350836-1enteev7	295	31	used	use	VBN
cord-350836-1enteev7	295	32	in	in	IN
cord-350836-1enteev7	295	33	this	this	DT
cord-350836-1enteev7	295	34	study	study	NN
cord-350836-1enteev7	295	35	(	(	-LRB-
cord-350836-1enteev7	295	36	245	245	CD
cord-350836-1enteev7	295	37	)	)	-RRB-
cord-350836-1enteev7	295	38	and	and	CC
cord-350836-1enteev7	295	39	that	that	DT
cord-350836-1enteev7	295	40	host	host	NN
cord-350836-1enteev7	295	41	RNA	rna	NN
cord-350836-1enteev7	295	42	binding	bind	VBG
cord-350836-1enteev7	295	43	proteins	protein	NNS
cord-350836-1enteev7	295	44	normally	normally	RB
cord-350836-1enteev7	295	45	prevent	prevent	VBP
cord-350836-1enteev7	295	46	endogenous	endogenous	JJ
cord-350836-1enteev7	295	47	circRNAs	circrna	NNS
cord-350836-1enteev7	295	48	from	from	IN
cord-350836-1enteev7	295	49	being	be	VBG
cord-350836-1enteev7	295	50	detected	detect	VBN
cord-350836-1enteev7	295	51	by	by	IN
cord-350836-1enteev7	295	52	the	the	DT
cord-350836-1enteev7	295	53	innate	innate	JJ
cord-350836-1enteev7	295	54	immune	immune	JJ
cord-350836-1enteev7	295	55	system	system	NN
cord-350836-1enteev7	295	56	.	.	.
cord-350836-1enteev7	296	1	Nevertheless	nevertheless	RB
cord-350836-1enteev7	296	2	,	,	,
cord-350836-1enteev7	296	3	some	some	DT
cord-350836-1enteev7	296	4	viral	viral	JJ
cord-350836-1enteev7	296	5	infections	infection	NNS
cord-350836-1enteev7	296	6	can	can	MD
cord-350836-1enteev7	296	7	potentially	potentially	RB
cord-350836-1enteev7	296	8	expose	expose	VB
cord-350836-1enteev7	296	9	these	these	DT
cord-350836-1enteev7	296	10	endogenous	endogenous	JJ
cord-350836-1enteev7	296	11	circRNAs	circrna	NNS
cord-350836-1enteev7	296	12	for	for	IN
cord-350836-1enteev7	296	13	immune	immune	JJ
cord-350836-1enteev7	296	14	detection	detection	NN
cord-350836-1enteev7	296	15	,	,	,
cord-350836-1enteev7	296	16	as	as	IN
cord-350836-1enteev7	296	17	has	have	VBZ
cord-350836-1enteev7	296	18	recently	recently	RB
cord-350836-1enteev7	296	19	been	be	VBN
cord-350836-1enteev7	296	20	found	find	VBN
cord-350836-1enteev7	296	21	to	to	TO
cord-350836-1enteev7	296	22	be	be	VB
cord-350836-1enteev7	296	23	the	the	DT
cord-350836-1enteev7	296	24	case	case	NN
cord-350836-1enteev7	296	25	for	for	IN
cord-350836-1enteev7	296	26	a	a	DT
cord-350836-1enteev7	296	27	novel	novel	JJ
cord-350836-1enteev7	296	28	host	host	NN
cord-350836-1enteev7	296	29	-	-	HYPH
cord-350836-1enteev7	296	30	derived	derive	VBN
cord-350836-1enteev7	296	31	circRNA	circrna	NN
cord-350836-1enteev7	296	32	(	(	-LRB-
cord-350836-1enteev7	296	33	lnc	lnc	NNP
cord-350836-1enteev7	296	34	-	-	HYPH
cord-350836-1enteev7	296	35	Lsm3b	Lsm3b	NNP
cord-350836-1enteev7	296	36	)	)	-RRB-
cord-350836-1enteev7	296	37	that	that	DT
cord-350836-1enteev7	296	38	is	be	VBZ
cord-350836-1enteev7	296	39	IFN	IFN	NNP
cord-350836-1enteev7	296	40	-	-	HYPH
cord-350836-1enteev7	296	41	inducible	inducible	JJ
cord-350836-1enteev7	296	42	and	and	CC
cord-350836-1enteev7	296	43	shows	show	VBZ
cord-350836-1enteev7	296	44	a	a	DT
cord-350836-1enteev7	296	45	down	down	JJ
cord-350836-1enteev7	296	46	-	-	HYPH
cord-350836-1enteev7	296	47	regulation	regulation	NN
cord-350836-1enteev7	296	48	of	of	IN
cord-350836-1enteev7	296	49	its	-PRON-	PRP$
cord-350836-1enteev7	296	50	binding	binding	NN
cord-350836-1enteev7	296	51	to	to	TO
cord-350836-1enteev7	296	52	host	host	VB
cord-350836-1enteev7	296	53	proteins	protein	NNS
cord-350836-1enteev7	296	54	during	during	IN
cord-350836-1enteev7	296	55	viral	viral	JJ
cord-350836-1enteev7	296	56	infection	infection	NN
cord-350836-1enteev7	296	57	and	and	CC
cord-350836-1enteev7	296	58	therefore	therefore	RB
cord-350836-1enteev7	296	59	appears	appear	VBZ
cord-350836-1enteev7	296	60	to	to	TO
cord-350836-1enteev7	296	61	compete	compete	VB
cord-350836-1enteev7	296	62	with	with	IN
cord-350836-1enteev7	296	63	viral	viral	JJ
cord-350836-1enteev7	296	64	dsRNA	dsrna	NN
cord-350836-1enteev7	296	65	as	as	IN
cord-350836-1enteev7	296	66	an	an	DT
cord-350836-1enteev7	296	67	inhibitor	inhibitor	NN
cord-350836-1enteev7	296	68	of	of	IN
cord-350836-1enteev7	296	69	the	the	DT
cord-350836-1enteev7	296	70	RIG	rig	NN
cord-350836-1enteev7	296	71	-	-	:
cord-350836-1enteev7	296	72	I	-PRON-	PRP
cord-350836-1enteev7	296	73	signaling	signal	VBG
cord-350836-1enteev7	296	74	feedback	feedback	NN
cord-350836-1enteev7	296	75	loop	loop	NN
cord-350836-1enteev7	296	76	(	(	-LRB-
cord-350836-1enteev7	296	77	198	198	CD
cord-350836-1enteev7	296	78	)	)	-RRB-
cord-350836-1enteev7	296	79	.	.	.
cord-350836-1enteev7	297	1	Similar	similar	JJ
cord-350836-1enteev7	297	2	inhibitory	inhibitory	JJ
cord-350836-1enteev7	297	3	mechanisms	mechanism	NNS
cord-350836-1enteev7	297	4	have	have	VBP
cord-350836-1enteev7	297	5	also	also	RB
cord-350836-1enteev7	297	6	been	be	VBN
cord-350836-1enteev7	297	7	noted	note	VBN
cord-350836-1enteev7	297	8	for	for	IN
cord-350836-1enteev7	297	9	RNA	RNA	NNP
cord-350836-1enteev7	297	10	products	product	NNS
cord-350836-1enteev7	297	11	of	of	IN
cord-350836-1enteev7	297	12	the	the	DT
cord-350836-1enteev7	297	13	exonuclease	exonuclease	NN
cord-350836-1enteev7	297	14	SKIV2L	skiv2l	NN
cord-350836-1enteev7	297	15	(	(	-LRB-
cord-350836-1enteev7	297	16	246	246	CD
cord-350836-1enteev7	297	17	)	)	-RRB-
cord-350836-1enteev7	297	18	.	.	.
cord-350836-1enteev7	298	1	Finally	finally	RB
cord-350836-1enteev7	298	2	,	,	,
cord-350836-1enteev7	298	3	recent	recent	JJ
cord-350836-1enteev7	298	4	studies	study	NNS
cord-350836-1enteev7	298	5	have	have	VBP
cord-350836-1enteev7	298	6	found	find	VBN
cord-350836-1enteev7	298	7	that	that	IN
cord-350836-1enteev7	298	8	hepatitis	hepatitis	NN
cord-350836-1enteev7	298	9	C	c	NN
cord-350836-1enteev7	298	10	virus	virus	NN
cord-350836-1enteev7	298	11	(	(	-LRB-
cord-350836-1enteev7	298	12	HCV	HCV	NNP
cord-350836-1enteev7	298	13	)	)	-RRB-
cord-350836-1enteev7	298	14	infection	infection	NN
cord-350836-1enteev7	298	15	increases	increase	VBZ
cord-350836-1enteev7	298	16	the	the	DT
cord-350836-1enteev7	298	17	expression	expression	NN
cord-350836-1enteev7	298	18	of	of	IN
cord-350836-1enteev7	298	19	certain	certain	JJ
cord-350836-1enteev7	298	20	cellular	cellular	JJ
cord-350836-1enteev7	298	21	RNAs	rna	NNS
cord-350836-1enteev7	298	22	that	that	WDT
cord-350836-1enteev7	298	23	can	can	MD
cord-350836-1enteev7	298	24	inhibit	inhibit	VB
cord-350836-1enteev7	298	25	RIG	rig	NN
cord-350836-1enteev7	298	26	-	-	:
cord-350836-1enteev7	298	27	I	-PRON-	PRP
cord-350836-1enteev7	298	28	function	function	VBP
cord-350836-1enteev7	298	29	.	.	.
cord-350836-1enteev7	299	1	HCV	HCV	NNP
cord-350836-1enteev7	299	2	infection	infection	NN
cord-350836-1enteev7	299	3	increased	increase	VBD
cord-350836-1enteev7	299	4	the	the	DT
cord-350836-1enteev7	299	5	mRNA	mRNA	NNP
cord-350836-1enteev7	299	6	levels	level	NNS
cord-350836-1enteev7	299	7	of	of	IN
cord-350836-1enteev7	299	8	hepatic	hepatic	JJ
cord-350836-1enteev7	299	9	selenoprotein	selenoprotein	NN
cord-350836-1enteev7	299	10	,	,	,
cord-350836-1enteev7	300	1	which	which	WDT
cord-350836-1enteev7	300	2	was	be	VBD
cord-350836-1enteev7	300	3	able	able	JJ
cord-350836-1enteev7	300	4	to	to	TO
cord-350836-1enteev7	300	5	bind	bind	VB
cord-350836-1enteev7	300	6	to	to	IN
cord-350836-1enteev7	300	7	RIG	rig	NN
cord-350836-1enteev7	300	8	-	-	:
cord-350836-1enteev7	300	9	I	-PRON-	PRP
cord-350836-1enteev7	300	10	through	through	IN
cord-350836-1enteev7	300	11	a	a	DT
cord-350836-1enteev7	300	12	hairpin	hairpin	JJ
cord-350836-1enteev7	300	13	structure	structure	NN
cord-350836-1enteev7	300	14	and	and	CC
cord-350836-1enteev7	300	15	inactivated	inactivate	VBD
cord-350836-1enteev7	300	16	it	-PRON-	PRP
cord-350836-1enteev7	300	17	during	during	IN
cord-350836-1enteev7	300	18	viral	viral	JJ
cord-350836-1enteev7	300	19	infection	infection	NN
cord-350836-1enteev7	300	20	(	(	-LRB-
cord-350836-1enteev7	300	21	247	247	CD
cord-350836-1enteev7	300	22	)	)	-RRB-
cord-350836-1enteev7	300	23	.	.	.
cord-350836-1enteev7	301	1	Infection	infection	NN
cord-350836-1enteev7	301	2	by	by	IN
cord-350836-1enteev7	301	3	HCV	HCV	NNP
cord-350836-1enteev7	301	4	,	,	,
cord-350836-1enteev7	301	5	vesicular	vesicular	JJ
cord-350836-1enteev7	301	6	stomatitis	stomatitis	NN
cord-350836-1enteev7	301	7	virus	virus	NN
cord-350836-1enteev7	301	8	(	(	-LRB-
cord-350836-1enteev7	301	9	VSV	VSV	NNP
cord-350836-1enteev7	301	10	)	)	-RRB-
cord-350836-1enteev7	301	11	,	,	,
cord-350836-1enteev7	301	12	or	or	CC
cord-350836-1enteev7	301	13	Sendai	Sendai	NNP
cord-350836-1enteev7	301	14	virus	virus	NN
cord-350836-1enteev7	301	15	,	,	,
cord-350836-1enteev7	301	16	or	or	CC
cord-350836-1enteev7	301	17	direct	direct	JJ
cord-350836-1enteev7	301	18	exposure	exposure	NN
cord-350836-1enteev7	301	19	of	of	IN
cord-350836-1enteev7	301	20	cells	cell	NNS
cord-350836-1enteev7	301	21	to	to	TO
cord-350836-1enteev7	301	22	type	type	NN
cord-350836-1enteev7	301	23	1	1	CD
cord-350836-1enteev7	301	24	and	and	CC
cord-350836-1enteev7	301	25	3	3	CD
cord-350836-1enteev7	301	26	interferons	interferon	NNS
cord-350836-1enteev7	301	27	increases	increase	VBZ
cord-350836-1enteev7	301	28	expression	expression	NN
cord-350836-1enteev7	301	29	of	of	IN
cord-350836-1enteev7	301	30	the	the	DT
cord-350836-1enteev7	301	31	cellular	cellular	JJ
cord-350836-1enteev7	301	32	long	long	JJ
cord-350836-1enteev7	301	33	non	non	JJ
cord-350836-1enteev7	301	34	-	-	JJ
cord-350836-1enteev7	301	35	coding	coding	JJ
cord-350836-1enteev7	301	36	RNA	RNA	NNP
cord-350836-1enteev7	301	37	(	(	-LRB-
cord-350836-1enteev7	301	38	lncRNA	lncRNA	NNP
cord-350836-1enteev7	301	39	)	)	-RRB-
cord-350836-1enteev7	301	40	,	,	,
cord-350836-1enteev7	301	41	namely	namely	RB
cord-350836-1enteev7	301	42	lncATV	lncATV	NNP
cord-350836-1enteev7	301	43	,	,	,
cord-350836-1enteev7	301	44	which	which	WDT
cord-350836-1enteev7	301	45	similarly	similarly	RB
cord-350836-1enteev7	301	46	inhibits	inhibit	VBZ
cord-350836-1enteev7	301	47	RIG	rig	NN
cord-350836-1enteev7	301	48	-	-	:
cord-350836-1enteev7	301	49	I	-PRON-	PRP
cord-350836-1enteev7	301	50	function	function	VBP
cord-350836-1enteev7	301	51	by	by	IN
cord-350836-1enteev7	301	52	directly	directly	RB
cord-350836-1enteev7	301	53	interacting	interact	VBG
cord-350836-1enteev7	301	54	with	with	IN
cord-350836-1enteev7	301	55	it	-PRON-	PRP
cord-350836-1enteev7	301	56	in	in	IN
cord-350836-1enteev7	301	57	order	order	NN
cord-350836-1enteev7	301	58	to	to	TO
cord-350836-1enteev7	301	59	promote	promote	VB
cord-350836-1enteev7	301	60	virus	virus	NN
cord-350836-1enteev7	301	61	replication	replication	NN
cord-350836-1enteev7	301	62	(	(	-LRB-
cord-350836-1enteev7	301	63	248	248	CD
cord-350836-1enteev7	301	64	)	)	-RRB-
cord-350836-1enteev7	301	65	.	.	.
cord-350836-1enteev7	302	1	In	in	IN
cord-350836-1enteev7	302	2	addition	addition	NN
cord-350836-1enteev7	302	3	to	to	IN
cord-350836-1enteev7	302	4	the	the	DT
cord-350836-1enteev7	302	5	greatly	greatly	RB
cord-350836-1enteev7	302	6	increased	increase	VBN
cord-350836-1enteev7	302	7	implications	implication	NNS
cord-350836-1enteev7	302	8	of	of	IN
cord-350836-1enteev7	302	9	RIG	rig	NN
cord-350836-1enteev7	302	10	-	-	:
cord-350836-1enteev7	302	11	I	I	NNP
cord-350836-1enteev7	302	12	and	and	CC
cord-350836-1enteev7	302	13	MDA5	mda5	JJ
cord-350836-1enteev7	302	14	modulation	modulation	NN
cord-350836-1enteev7	302	15	,	,	,
cord-350836-1enteev7	302	16	these	these	DT
cord-350836-1enteev7	302	17	findings	finding	NNS
cord-350836-1enteev7	302	18	also	also	RB
cord-350836-1enteev7	302	19	have	have	VBP
cord-350836-1enteev7	302	20	significant	significant	JJ
cord-350836-1enteev7	302	21	implications	implication	NNS
cord-350836-1enteev7	302	22	in	in	IN
cord-350836-1enteev7	302	23	characterizing	characterize	VBG
cord-350836-1enteev7	302	24	new	new	JJ
cord-350836-1enteev7	302	25	biomarkers	biomarker	NNS
cord-350836-1enteev7	302	26	of	of	IN
cord-350836-1enteev7	302	27	disease	disease	NN
cord-350836-1enteev7	302	28	,	,	,
cord-350836-1enteev7	302	29	as	as	IN
cord-350836-1enteev7	302	30	increased	increase	VBN
cord-350836-1enteev7	302	31	serum	serum	NN
cord-350836-1enteev7	302	32	selenoprotein	selenoprotein	JJ
cord-350836-1enteev7	302	33	level	level	NN
cord-350836-1enteev7	302	34	has	have	VBZ
cord-350836-1enteev7	302	35	been	be	VBN
cord-350836-1enteev7	302	36	found	find	VBN
cord-350836-1enteev7	302	37	to	to	TO
cord-350836-1enteev7	302	38	significantly	significantly	RB
cord-350836-1enteev7	302	39	associate	associate	VB
cord-350836-1enteev7	302	40	with	with	IN
cord-350836-1enteev7	302	41	treatment	treatment	NN
cord-350836-1enteev7	302	42	failure	failure	NN
cord-350836-1enteev7	302	43	of	of	IN
cord-350836-1enteev7	302	44	anti	anti	JJ
cord-350836-1enteev7	302	45	-	-	JJ
cord-350836-1enteev7	302	46	viral	viral	JJ
cord-350836-1enteev7	302	47	drugs	drug	NNS
cord-350836-1enteev7	302	48	in	in	IN
cord-350836-1enteev7	302	49	HCV	HCV	NNP
cord-350836-1enteev7	302	50	patients	patient	NNS
cord-350836-1enteev7	302	51	,	,	,
cord-350836-1enteev7	302	52	and	and	CC
cord-350836-1enteev7	302	53	can	can	MD
cord-350836-1enteev7	302	54	possibly	possibly	RB
cord-350836-1enteev7	302	55	explain	explain	VB
cord-350836-1enteev7	302	56	the	the	DT
cord-350836-1enteev7	302	57	increased	increase	VBN
cord-350836-1enteev7	302	58	prevalence	prevalence	NN
cord-350836-1enteev7	302	59	of	of	IN
cord-350836-1enteev7	302	60	type	type	NN
cord-350836-1enteev7	302	61	2	2	CD
cord-350836-1enteev7	302	62	diabetes	diabete	NNS
cord-350836-1enteev7	302	63	in	in	IN
cord-350836-1enteev7	302	64	HCV	HCV	NNP
cord-350836-1enteev7	302	65	patients	patient	NNS
cord-350836-1enteev7	302	66	(	(	-LRB-
cord-350836-1enteev7	302	67	247	247	CD
cord-350836-1enteev7	302	68	)	)	-RRB-
cord-350836-1enteev7	302	69	.	.	.
cord-350836-1enteev7	303	1	Cellular	Cellular	NNP
cord-350836-1enteev7	303	2	RNA	RNA	NNP
cord-350836-1enteev7	303	3	has	have	VBZ
cord-350836-1enteev7	303	4	also	also	RB
cord-350836-1enteev7	303	5	been	be	VBN
cord-350836-1enteev7	303	6	found	find	VBN
cord-350836-1enteev7	303	7	to	to	TO
cord-350836-1enteev7	303	8	activate	activate	VB
cord-350836-1enteev7	303	9	RLR	RLR	NNP
cord-350836-1enteev7	303	10	signaling	signal	VBG
cord-350836-1enteev7	303	11	during	during	IN
cord-350836-1enteev7	303	12	viral	viral	JJ
cord-350836-1enteev7	303	13	infection	infection	NN
cord-350836-1enteev7	303	14	.	.	.
cord-350836-1enteev7	304	1	Vault	Vault	NNP
cord-350836-1enteev7	304	2	RNAs	rna	NNS
cord-350836-1enteev7	304	3	,	,	,
cord-350836-1enteev7	304	4	which	which	WDT
cord-350836-1enteev7	304	5	are	be	VBP
cord-350836-1enteev7	304	6	transcribed	transcribe	VBN
cord-350836-1enteev7	304	7	from	from	IN
cord-350836-1enteev7	304	8	four	four	CD
cord-350836-1enteev7	304	9	genes	gene	NNS
cord-350836-1enteev7	304	10	and	and	CC
cord-350836-1enteev7	304	11	are	be	VBP
cord-350836-1enteev7	304	12	normally	normally	RB
cord-350836-1enteev7	304	13	found	find	VBN
cord-350836-1enteev7	304	14	in	in	IN
cord-350836-1enteev7	304	15	large	large	JJ
cord-350836-1enteev7	304	16	ribonucleoprotein	ribonucleoprotein	NN
cord-350836-1enteev7	304	17	complexes	complex	NNS
cord-350836-1enteev7	304	18	in	in	IN
cord-350836-1enteev7	304	19	cytoplasmic	cytoplasmic	JJ
cord-350836-1enteev7	304	20	"	"	``
cord-350836-1enteev7	304	21	vaults	vault	NNS
cord-350836-1enteev7	304	22	,	,	,
cord-350836-1enteev7	304	23	"	"	''
cord-350836-1enteev7	304	24	are	be	VBP
cord-350836-1enteev7	304	25	significantly	significantly	RB
cord-350836-1enteev7	304	26	enriched	enrich	VBN
cord-350836-1enteev7	304	27	for	for	IN
cord-350836-1enteev7	304	28	binding	bind	VBG
cord-350836-1enteev7	304	29	to	to	IN
cord-350836-1enteev7	304	30	RIG	rig	NN
cord-350836-1enteev7	305	1	-I	-i	WDT
cord-350836-1enteev7	305	2	during	during	IN
cord-350836-1enteev7	305	3	infection	infection	NN
cord-350836-1enteev7	305	4	with	with	IN
cord-350836-1enteev7	305	5	KSHV	KSHV	NNP
cord-350836-1enteev7	305	6	(	(	-LRB-
cord-350836-1enteev7	305	7	29	29	CD
cord-350836-1enteev7	305	8	)	)	-RRB-
cord-350836-1enteev7	305	9	.	.	.
cord-350836-1enteev7	306	1	This	this	DT
cord-350836-1enteev7	306	2	may	may	MD
cord-350836-1enteev7	306	3	be	be	VB
cord-350836-1enteev7	306	4	due	due	JJ
cord-350836-1enteev7	306	5	partly	partly	RB
cord-350836-1enteev7	306	6	to	to	IN
cord-350836-1enteev7	306	7	viral	viral	JJ
cord-350836-1enteev7	306	8	infection	infection	NN
cord-350836-1enteev7	306	9	-	-	HYPH
cord-350836-1enteev7	306	10	induced	induce	VBN
cord-350836-1enteev7	306	11	reduction	reduction	NN
cord-350836-1enteev7	306	12	in	in	IN
cord-350836-1enteev7	306	13	the	the	DT
cord-350836-1enteev7	306	14	level	level	NN
cord-350836-1enteev7	306	15	of	of	IN
cord-350836-1enteev7	306	16	cellular	cellular	JJ
cord-350836-1enteev7	306	17	triphosphatase	triphosphatase	NN
cord-350836-1enteev7	306	18	DUSP11	dusp11	NN
cord-350836-1enteev7	306	19	,	,	,
cord-350836-1enteev7	306	20	which	which	WDT
cord-350836-1enteev7	306	21	dephosphorylates	dephosphorylate	VBZ
cord-350836-1enteev7	306	22	the	the	DT
cord-350836-1enteev7	306	23	5	5	CD
cord-350836-1enteev7	306	24	′	′	CD
cord-350836-1enteev7	306	25	ppp	ppp	NN
cord-350836-1enteev7	306	26	group	group	NN
cord-350836-1enteev7	306	27	on	on	IN
cord-350836-1enteev7	306	28	the	the	DT
cord-350836-1enteev7	306	29	vault	vault	NN
cord-350836-1enteev7	306	30	RNAs	rna	NNS
cord-350836-1enteev7	306	31	,	,	,
cord-350836-1enteev7	306	32	as	as	IN
cord-350836-1enteev7	306	33	they	-PRON-	PRP
cord-350836-1enteev7	306	34	could	could	MD
cord-350836-1enteev7	306	35	only	only	RB
cord-350836-1enteev7	306	36	be	be	VB
cord-350836-1enteev7	306	37	immunogenic	immunogenic	JJ
cord-350836-1enteev7	306	38	(	(	-LRB-
cord-350836-1enteev7	306	39	in	in	IN
cord-350836-1enteev7	306	40	the	the	DT
cord-350836-1enteev7	306	41	absence	absence	NN
cord-350836-1enteev7	306	42	of	of	IN
cord-350836-1enteev7	306	43	viral	viral	JJ
cord-350836-1enteev7	306	44	infection	infection	NN
cord-350836-1enteev7	306	45	)	)	-RRB-
cord-350836-1enteev7	306	46	by	by	IN
cord-350836-1enteev7	306	47	the	the	DT
cord-350836-1enteev7	306	48	addition	addition	NN
cord-350836-1enteev7	306	49	of	of	IN
cord-350836-1enteev7	306	50	the	the	DT
cord-350836-1enteev7	306	51	5	5	CD
cord-350836-1enteev7	306	52	′	′	CD
cord-350836-1enteev7	306	53	ppp	ppp	NN
cord-350836-1enteev7	306	54	group	group	NN
cord-350836-1enteev7	306	55	.	.	.
cord-350836-1enteev7	307	1	RIG	rig	NN
cord-350836-1enteev7	307	2	-	-	:
cord-350836-1enteev7	307	3	I	I	NNP
cord-350836-1enteev7	307	4	and	and	CC
cord-350836-1enteev7	307	5	MDA5	MDA5	NNP
cord-350836-1enteev7	307	6	have	have	VBP
cord-350836-1enteev7	307	7	also	also	RB
cord-350836-1enteev7	307	8	been	be	VBN
cord-350836-1enteev7	307	9	found	find	VBN
cord-350836-1enteev7	307	10	to	to	TO
cord-350836-1enteev7	307	11	be	be	VB
cord-350836-1enteev7	307	12	activated	activate	VBN
cord-350836-1enteev7	307	13	by	by	IN
cord-350836-1enteev7	307	14	RNA	RNA	NNP
cord-350836-1enteev7	307	15	microparticles	microparticle	NNS
cord-350836-1enteev7	307	16	produced	produce	VBN
cord-350836-1enteev7	307	17	in	in	IN
cord-350836-1enteev7	307	18	situ	situ	NNS
cord-350836-1enteev7	307	19	by	by	IN
cord-350836-1enteev7	307	20	rolling	roll	VBG
cord-350836-1enteev7	307	21	circle	circle	NN
cord-350836-1enteev7	307	22	transcription	transcription	NN
cord-350836-1enteev7	307	23	,	,	,
cord-350836-1enteev7	307	24	generating	generate	VBG
cord-350836-1enteev7	307	25	tandem	tandem	NN
cord-350836-1enteev7	307	26	repeat	repeat	NN
cord-350836-1enteev7	307	27	RNA	RNA	NNP
cord-350836-1enteev7	307	28	strands	strand	NNS
cord-350836-1enteev7	307	29	(	(	-LRB-
cord-350836-1enteev7	307	30	249	249	CD
cord-350836-1enteev7	307	31	)	)	-RRB-
cord-350836-1enteev7	307	32	.	.	.
cord-350836-1enteev7	308	1	Retrotransposons	retrotransposon	NNS
cord-350836-1enteev7	308	2	may	may	MD
cord-350836-1enteev7	308	3	also	also	RB
cord-350836-1enteev7	308	4	be	be	VB
cord-350836-1enteev7	308	5	able	able	JJ
cord-350836-1enteev7	308	6	to	to	TO
cord-350836-1enteev7	308	7	activate	activate	VB
cord-350836-1enteev7	308	8	both	both	DT
cord-350836-1enteev7	308	9	RIG	rig	NN
cord-350836-1enteev7	308	10	-	-	:
cord-350836-1enteev7	308	11	I	I	NNP
cord-350836-1enteev7	308	12	and	and	CC
cord-350836-1enteev7	308	13	MDA5	MDA5	NNP
cord-350836-1enteev7	308	14	,	,	,
cord-350836-1enteev7	308	15	as	as	IN
cord-350836-1enteev7	308	16	both	both	DT
cord-350836-1enteev7	308	17	can	can	MD
cord-350836-1enteev7	308	18	be	be	VB
cord-350836-1enteev7	308	19	activated	activate	VBN
cord-350836-1enteev7	308	20	by	by	IN
cord-350836-1enteev7	308	21	LINE1	LINE1	NNP
cord-350836-1enteev7	308	22	RNA	RNA	NNP
cord-350836-1enteev7	308	23	independently	independently	RB
cord-350836-1enteev7	308	24	of	of	IN
cord-350836-1enteev7	308	25	DNA	dna	NN
cord-350836-1enteev7	308	26	sensing	sensing	NN
cord-350836-1enteev7	308	27	mechanisms	mechanism	NNS
cord-350836-1enteev7	308	28	and	and	CC
cord-350836-1enteev7	308	29	retrotransposition	retrotransposition	NN
cord-350836-1enteev7	308	30	(	(	-LRB-
cord-350836-1enteev7	308	31	250	250	CD
cord-350836-1enteev7	308	32	)	)	-RRB-
cord-350836-1enteev7	308	33	.	.	.
cord-350836-1enteev7	309	1	Viral	viral	JJ
cord-350836-1enteev7	309	2	infections	infection	NNS
cord-350836-1enteev7	309	3	can	can	MD
cord-350836-1enteev7	309	4	also	also	RB
cord-350836-1enteev7	309	5	induce	induce	VB
cord-350836-1enteev7	309	6	recognition	recognition	NN
cord-350836-1enteev7	309	7	of	of	IN
cord-350836-1enteev7	309	8	host	host	NN
cord-350836-1enteev7	309	9	RNAs	rna	NNS
cord-350836-1enteev7	309	10	.	.	.
cord-350836-1enteev7	310	1	Herpes	Herpes	NNP
cord-350836-1enteev7	310	2	Simplex	Simplex	NNP
cord-350836-1enteev7	310	3	Virus	Virus	NNP
cord-350836-1enteev7	310	4	1	1	CD
cord-350836-1enteev7	310	5	(	(	-LRB-
cord-350836-1enteev7	310	6	HSV1	HSV1	NNP
cord-350836-1enteev7	310	7	)	)	-RRB-
cord-350836-1enteev7	310	8	infection	infection	NN
cord-350836-1enteev7	310	9	,	,	,
cord-350836-1enteev7	310	10	for	for	IN
cord-350836-1enteev7	310	11	example	example	NN
cord-350836-1enteev7	310	12	,	,	,
cord-350836-1enteev7	310	13	has	have	VBZ
cord-350836-1enteev7	310	14	been	be	VBN
cord-350836-1enteev7	310	15	shown	show	VBN
cord-350836-1enteev7	310	16	to	to	TO
cord-350836-1enteev7	310	17	induce	induce	VB
cord-350836-1enteev7	310	18	translocation	translocation	NN
cord-350836-1enteev7	310	19	of	of	IN
cord-350836-1enteev7	310	20	the	the	DT
cord-350836-1enteev7	310	21	host	host	NN
cord-350836-1enteev7	310	22	pseudogene	pseudogene	NN
cord-350836-1enteev7	310	23	RNA5SP141	RNA5SP141	NNP
cord-350836-1enteev7	310	24	ribosomal	ribosomal	NNP
cord-350836-1enteev7	310	25	RNA	RNA	NNP
cord-350836-1enteev7	310	26	into	into	IN
cord-350836-1enteev7	310	27	the	the	DT
cord-350836-1enteev7	310	28	cytosol	cytosol	NN
cord-350836-1enteev7	310	29	to	to	TO
cord-350836-1enteev7	310	30	bind	bind	VB
cord-350836-1enteev7	310	31	to	to	IN
cord-350836-1enteev7	310	32	RIG	rig	NN
cord-350836-1enteev7	310	33	-	-	HYPH
cord-350836-1enteev7	310	34	I.	I.	NNP
cord-350836-1enteev7	310	35	Knockdown	Knockdown	NNP
cord-350836-1enteev7	310	36	of	of	IN
cord-350836-1enteev7	310	37	RNA5SP141	RNA5SP141	NNP
cord-350836-1enteev7	310	38	decreased	decrease	VBD
cord-350836-1enteev7	310	39	cytokine	cytokine	NN
cord-350836-1enteev7	310	40	signaling	signal	VBG
cord-350836-1enteev7	310	41	during	during	IN
cord-350836-1enteev7	310	42	infection	infection	NN
cord-350836-1enteev7	310	43	with	with	IN
cord-350836-1enteev7	310	44	HSV	HSV	NNP
cord-350836-1enteev7	310	45	and	and	CC
cord-350836-1enteev7	310	46	EBV	EBV	NNP
cord-350836-1enteev7	310	47	as	as	RB
cord-350836-1enteev7	310	48	well	well	RB
cord-350836-1enteev7	310	49	as	as	IN
cord-350836-1enteev7	310	50	influenza	influenza	NN
cord-350836-1enteev7	310	51	A	a	DT
cord-350836-1enteev7	310	52	virus	virus	NN
cord-350836-1enteev7	310	53	(	(	-LRB-
cord-350836-1enteev7	310	54	IAV	IAV	NNP
cord-350836-1enteev7	310	55	)	)	-RRB-
cord-350836-1enteev7	310	56	(	(	-LRB-
cord-350836-1enteev7	310	57	251	251	CD
cord-350836-1enteev7	310	58	)	)	-RRB-
cord-350836-1enteev7	310	59	.	.	.
cord-350836-1enteev7	311	1	RIG	rig	NN
cord-350836-1enteev7	311	2	-	-	:
cord-350836-1enteev7	311	3	I	-PRON-	PRP
cord-350836-1enteev7	311	4	has	have	VBZ
cord-350836-1enteev7	311	5	also	also	RB
cord-350836-1enteev7	311	6	been	be	VBN
cord-350836-1enteev7	311	7	found	find	VBN
cord-350836-1enteev7	311	8	to	to	TO
cord-350836-1enteev7	311	9	be	be	VB
cord-350836-1enteev7	311	10	activated	activate	VBN
cord-350836-1enteev7	311	11	by	by	IN
cord-350836-1enteev7	311	12	hairpin	hairpin	NN
cord-350836-1enteev7	311	13	RNA	RNA	NNP
cord-350836-1enteev7	311	14	structures	structure	NNS
cord-350836-1enteev7	311	15	generated	generate	VBN
cord-350836-1enteev7	311	16	by	by	IN
cord-350836-1enteev7	311	17	cleavage	cleavage	NN
cord-350836-1enteev7	311	18	of	of	IN
cord-350836-1enteev7	311	19	RNA	RNA	NNP
cord-350836-1enteev7	311	20	by	by	IN
cord-350836-1enteev7	311	21	RNase	RNase	NNP
cord-350836-1enteev7	311	22	L	L	NNP
cord-350836-1enteev7	311	23	,	,	,
cord-350836-1enteev7	311	24	which	which	WDT
cord-350836-1enteev7	311	25	has	have	VBZ
cord-350836-1enteev7	311	26	been	be	VBN
cord-350836-1enteev7	311	27	demonstrated	demonstrate	VBN
cord-350836-1enteev7	311	28	to	to	TO
cord-350836-1enteev7	311	29	occur	occur	VB
cord-350836-1enteev7	311	30	during	during	IN
cord-350836-1enteev7	311	31	HCV	HCV	NNP
cord-350836-1enteev7	311	32	infection	infection	NN
cord-350836-1enteev7	311	33	(	(	-LRB-
cord-350836-1enteev7	311	34	179	179	CD
cord-350836-1enteev7	311	35	)	)	-RRB-
cord-350836-1enteev7	311	36	as	as	RB
cord-350836-1enteev7	311	37	well	well	RB
cord-350836-1enteev7	311	38	as	as	IN
cord-350836-1enteev7	311	39	from	from	IN
cord-350836-1enteev7	311	40	mitochondrial	mitochondrial	JJ
cord-350836-1enteev7	311	41	dsRNA	dsRNA	NNS
cord-350836-1enteev7	311	42	produced	produce	VBN
cord-350836-1enteev7	311	43	in	in	IN
cord-350836-1enteev7	311	44	p53	p53	NN
cord-350836-1enteev7	311	45	deficient	deficient	JJ
cord-350836-1enteev7	311	46	mice	mouse	NNS
cord-350836-1enteev7	311	47	(	(	-LRB-
cord-350836-1enteev7	311	48	180	180	CD
cord-350836-1enteev7	311	49	)	)	-RRB-
cord-350836-1enteev7	311	50	.	.	.
cord-350836-1enteev7	312	1	The	the	DT
cord-350836-1enteev7	312	2	mitochondria	mitochondrion	NNS
cord-350836-1enteev7	312	3	,	,	,
cord-350836-1enteev7	312	4	in	in	IN
cord-350836-1enteev7	312	5	particular	particular	JJ
cord-350836-1enteev7	312	6	,	,	,
cord-350836-1enteev7	312	7	may	may	MD
cord-350836-1enteev7	312	8	be	be	VB
cord-350836-1enteev7	312	9	an	an	DT
cord-350836-1enteev7	312	10	important	important	JJ
cord-350836-1enteev7	312	11	source	source	NN
cord-350836-1enteev7	312	12	of	of	IN
cord-350836-1enteev7	312	13	immunostimulatory	immunostimulatory	NNP
cord-350836-1enteev7	312	14	host	host	NNP
cord-350836-1enteev7	312	15	dsRNA	dsRNA	NNP
cord-350836-1enteev7	312	16	.	.	.
cord-350836-1enteev7	313	1	Viral	viral	JJ
cord-350836-1enteev7	313	2	infections	infection	NNS
cord-350836-1enteev7	313	3	are	be	VBP
cord-350836-1enteev7	313	4	well	well	RB
cord-350836-1enteev7	313	5	-	-	HYPH
cord-350836-1enteev7	313	6	known	know	VBN
cord-350836-1enteev7	313	7	to	to	TO
cord-350836-1enteev7	313	8	cause	cause	VB
cord-350836-1enteev7	313	9	mitochondrial	mitochondrial	JJ
cord-350836-1enteev7	313	10	damage	damage	NN
cord-350836-1enteev7	313	11	(	(	-LRB-
cord-350836-1enteev7	313	12	252	252	CD
cord-350836-1enteev7	313	13	)	)	-RRB-
cord-350836-1enteev7	313	14	.	.	.
cord-350836-1enteev7	314	1	Knockdown	knockdown	NN
cord-350836-1enteev7	314	2	and	and	CC
cord-350836-1enteev7	314	3	hepatocyte	hepatocyte	NN
cord-350836-1enteev7	314	4	-	-	HYPH
cord-350836-1enteev7	314	5	specific	specific	JJ
cord-350836-1enteev7	314	6	conditional	conditional	JJ
cord-350836-1enteev7	314	7	KO	KO	NNP
cord-350836-1enteev7	314	8	of	of	IN
cord-350836-1enteev7	314	9	mitochondrial	mitochondrial	JJ
cord-350836-1enteev7	314	10	RNA	RNA	NNP
cord-350836-1enteev7	314	11	degrading	degrade	VBG
cord-350836-1enteev7	314	12	enzymes	enzyme	NNS
cord-350836-1enteev7	314	13	resulted	result	VBD
cord-350836-1enteev7	314	14	in	in	IN
cord-350836-1enteev7	314	15	the	the	DT
cord-350836-1enteev7	314	16	increase	increase	NN
cord-350836-1enteev7	314	17	of	of	IN
cord-350836-1enteev7	314	18	cytoplasmic	cytoplasmic	JJ
cord-350836-1enteev7	314	19	mitochondrial	mitochondrial	NN
cord-350836-1enteev7	314	20	dsRNA	dsRNA	NNS
cord-350836-1enteev7	314	21	which	which	WDT
cord-350836-1enteev7	314	22	was	be	VBD
cord-350836-1enteev7	314	23	able	able	JJ
cord-350836-1enteev7	314	24	to	to	TO
cord-350836-1enteev7	314	25	activate	activate	VB
cord-350836-1enteev7	314	26	MDA5	MDA5	NNP
cord-350836-1enteev7	314	27	(	(	-LRB-
cord-350836-1enteev7	314	28	253	253	CD
cord-350836-1enteev7	314	29	)	)	-RRB-
cord-350836-1enteev7	314	30	.	.	.
cord-350836-1enteev7	315	1	Additionally	additionally	RB
cord-350836-1enteev7	315	2	,	,	,
cord-350836-1enteev7	315	3	extracellular	extracellular	JJ
cord-350836-1enteev7	315	4	vesicles	vesicle	NNS
cord-350836-1enteev7	315	5	(	(	-LRB-
cord-350836-1enteev7	315	6	EV	ev	NN
cord-350836-1enteev7	315	7	)	)	-RRB-
cord-350836-1enteev7	315	8	secreted	secrete	VBN
cord-350836-1enteev7	315	9	by	by	IN
cord-350836-1enteev7	315	10	apoptotic	apoptotic	JJ
cord-350836-1enteev7	315	11	endothelial	endothelial	JJ
cord-350836-1enteev7	315	12	cells	cell	NNS
cord-350836-1enteev7	315	13	were	be	VBD
cord-350836-1enteev7	315	14	found	find	VBN
cord-350836-1enteev7	315	15	to	to	TO
cord-350836-1enteev7	315	16	contain	contain	VB
cord-350836-1enteev7	315	17	long	long	RB
cord-350836-1enteev7	315	18	interspersed	intersperse	VBN
cord-350836-1enteev7	315	19	nuclear	nuclear	JJ
cord-350836-1enteev7	315	20	element	element	NN
cord-350836-1enteev7	315	21	(	(	-LRB-
cord-350836-1enteev7	315	22	LINE	line	NN
cord-350836-1enteev7	315	23	)	)	-RRB-
cord-350836-1enteev7	315	24	and	and	CC
cord-350836-1enteev7	315	25	short	short	JJ
cord-350836-1enteev7	315	26	interspersed	intersperse	VBN
cord-350836-1enteev7	315	27	nuclear	nuclear	JJ
cord-350836-1enteev7	315	28	element	element	NN
cord-350836-1enteev7	315	29	(	(	-LRB-
cord-350836-1enteev7	315	30	SINE	SINE	NNP
cord-350836-1enteev7	315	31	)	)	-RRB-
cord-350836-1enteev7	315	32	RNAs	rna	NNS
cord-350836-1enteev7	315	33	that	that	WDT
cord-350836-1enteev7	315	34	are	be	VBP
cord-350836-1enteev7	315	35	products	product	NNS
cord-350836-1enteev7	315	36	of	of	IN
cord-350836-1enteev7	315	37	RNA	RNA	NNP
cord-350836-1enteev7	315	38	polymerase	polymerase	NN
cord-350836-1enteev7	315	39	III	III	NNP
cord-350836-1enteev7	315	40	and	and	CC
cord-350836-1enteev7	315	41	were	be	VBD
cord-350836-1enteev7	315	42	able	able	JJ
cord-350836-1enteev7	315	43	to	to	TO
cord-350836-1enteev7	315	44	activate	activate	VB
cord-350836-1enteev7	315	45	RIG	rig	NN
cord-350836-1enteev7	315	46	-	-	:
cord-350836-1enteev7	315	47	I	i	NN
cord-350836-1enteev7	315	48	signaling	signal	VBG
cord-350836-1enteev7	315	49	(	(	-LRB-
cord-350836-1enteev7	315	50	254	254	CD
cord-350836-1enteev7	315	51	)	)	-RRB-
cord-350836-1enteev7	315	52	.	.	.
cord-350836-1enteev7	316	1	Collectively	collectively	RB
cord-350836-1enteev7	316	2	,	,	,
cord-350836-1enteev7	316	3	these	these	DT
cord-350836-1enteev7	316	4	findings	finding	NNS
cord-350836-1enteev7	316	5	demonstrate	demonstrate	VBP
cord-350836-1enteev7	316	6	the	the	DT
cord-350836-1enteev7	316	7	many	many	JJ
cord-350836-1enteev7	316	8	unique	unique	JJ
cord-350836-1enteev7	316	9	ways	way	NNS
cord-350836-1enteev7	316	10	by	by	IN
cord-350836-1enteev7	316	11	which	which	WDT
cord-350836-1enteev7	316	12	cellular	cellular	JJ
cord-350836-1enteev7	316	13	RNAs	rna	NNS
cord-350836-1enteev7	316	14	can	can	MD
cord-350836-1enteev7	316	15	modulate	modulate	VB
cord-350836-1enteev7	316	16	RIG	rig	NN
cord-350836-1enteev7	316	17	-	-	:
cord-350836-1enteev7	316	18	I	I	NNP
cord-350836-1enteev7	316	19	and	and	CC
cord-350836-1enteev7	316	20	MDA5	MDA5	NNP
cord-350836-1enteev7	316	21	functions	function	NNS
cord-350836-1enteev7	316	22	as	as	RB
cord-350836-1enteev7	316	23	well	well	RB
cord-350836-1enteev7	316	24	as	as	IN
cord-350836-1enteev7	316	25	the	the	DT
cord-350836-1enteev7	316	26	potential	potential	JJ
cord-350836-1enteev7	316	27	implications	implication	NNS
cord-350836-1enteev7	316	28	of	of	IN
cord-350836-1enteev7	316	29	RIG	rig	NN
cord-350836-1enteev7	316	30	-	-	:
cord-350836-1enteev7	316	31	I	-PRON-	PRP
cord-350836-1enteev7	316	32	activation	activation	NN
cord-350836-1enteev7	316	33	by	by	IN
cord-350836-1enteev7	316	34	pharmaceuticals	pharmaceutical	NNS
cord-350836-1enteev7	316	35	as	as	IN
cord-350836-1enteev7	316	36	an	an	DT
cord-350836-1enteev7	316	37	anti	anti	JJ
cord-350836-1enteev7	316	38	-	-	JJ
cord-350836-1enteev7	316	39	viral	viral	JJ
cord-350836-1enteev7	316	40	or	or	CC
cord-350836-1enteev7	316	41	generalized	generalized	JJ
cord-350836-1enteev7	316	42	immunotherapy	immunotherapy	NN
cord-350836-1enteev7	316	43	,	,	,
cord-350836-1enteev7	316	44	though	though	IN
cord-350836-1enteev7	316	45	much	much	JJ
cord-350836-1enteev7	316	46	caution	caution	NN
cord-350836-1enteev7	316	47	and	and	CC
cord-350836-1enteev7	316	48	studies	study	NNS
cord-350836-1enteev7	316	49	would	would	MD
cord-350836-1enteev7	316	50	still	still	RB
cord-350836-1enteev7	316	51	be	be	VB
cord-350836-1enteev7	316	52	needed	need	VBN
cord-350836-1enteev7	316	53	to	to	TO
cord-350836-1enteev7	316	54	determine	determine	VB
cord-350836-1enteev7	316	55	the	the	DT
cord-350836-1enteev7	316	56	appropriate	appropriate	JJ
cord-350836-1enteev7	316	57	levels	level	NNS
cord-350836-1enteev7	316	58	of	of	IN
cord-350836-1enteev7	316	59	RIG	rig	NN
cord-350836-1enteev7	316	60	-	-	:
cord-350836-1enteev7	316	61	I	I	NNP
cord-350836-1enteev7	316	62	and	and	CC
cord-350836-1enteev7	316	63	MDA5	MDA5	NNP
cord-350836-1enteev7	316	64	activation	activation	NN
cord-350836-1enteev7	316	65	.	.	.
cord-350836-1enteev7	317	1	Given	give	VBN
cord-350836-1enteev7	317	2	that	that	DT
cord-350836-1enteev7	317	3	RIG	rig	NN
cord-350836-1enteev7	317	4	-	-	:
cord-350836-1enteev7	317	5	I	I	NNP
cord-350836-1enteev7	317	6	and	and	CC
cord-350836-1enteev7	317	7	MDA5	MDA5	NNP
cord-350836-1enteev7	317	8	are	be	VBP
cord-350836-1enteev7	317	9	critical	critical	JJ
cord-350836-1enteev7	317	10	for	for	IN
cord-350836-1enteev7	317	11	activating	activate	VBG
cord-350836-1enteev7	317	12	expression	expression	NN
cord-350836-1enteev7	317	13	of	of	IN
cord-350836-1enteev7	317	14	IFN1	IFN1	NNP
cord-350836-1enteev7	317	15	during	during	IN
cord-350836-1enteev7	317	16	viral	viral	JJ
cord-350836-1enteev7	317	17	infection	infection	NN
cord-350836-1enteev7	317	18	,	,	,
cord-350836-1enteev7	317	19	there	there	EX
cord-350836-1enteev7	317	20	is	be	VBZ
cord-350836-1enteev7	317	21	much	much	JJ
cord-350836-1enteev7	317	22	interest	interest	NN
cord-350836-1enteev7	317	23	in	in	IN
cord-350836-1enteev7	317	24	studying	study	VBG
cord-350836-1enteev7	317	25	the	the	DT
cord-350836-1enteev7	317	26	interactions	interaction	NNS
cord-350836-1enteev7	317	27	of	of	IN
cord-350836-1enteev7	317	28	these	these	DT
cord-350836-1enteev7	317	29	cellular	cellular	JJ
cord-350836-1enteev7	317	30	proteins	protein	NNS
cord-350836-1enteev7	317	31	with	with	IN
cord-350836-1enteev7	317	32	viral	viral	JJ
cord-350836-1enteev7	317	33	factors	factor	NNS
cord-350836-1enteev7	317	34	(	(	-LRB-
cord-350836-1enteev7	317	35	RNAs	rna	NNS
cord-350836-1enteev7	317	36	or	or	CC
cord-350836-1enteev7	317	37	proteins	protein	NNS
cord-350836-1enteev7	317	38	)	)	-RRB-
cord-350836-1enteev7	317	39	,	,	,
cord-350836-1enteev7	317	40	as	as	IN
cord-350836-1enteev7	317	41	the	the	DT
cord-350836-1enteev7	317	42	ability	ability	NN
cord-350836-1enteev7	317	43	to	to	TO
cord-350836-1enteev7	317	44	modulate	modulate	VB
cord-350836-1enteev7	317	45	interferon	interferon	JJ
cord-350836-1enteev7	317	46	expression	expression	NN
cord-350836-1enteev7	317	47	is	be	VBZ
cord-350836-1enteev7	317	48	a	a	DT
cord-350836-1enteev7	317	49	major	major	JJ
cord-350836-1enteev7	317	50	evolutionary	evolutionary	JJ
cord-350836-1enteev7	317	51	driving	drive	VBG
cord-350836-1enteev7	317	52	force	force	NN
cord-350836-1enteev7	317	53	in	in	IN
cord-350836-1enteev7	317	54	viral	viral	JJ
cord-350836-1enteev7	317	55	evolution	evolution	NN
cord-350836-1enteev7	317	56	(	(	-LRB-
cord-350836-1enteev7	317	57	255	255	CD
cord-350836-1enteev7	317	58	,	,	,
cord-350836-1enteev7	317	59	256	256	CD
cord-350836-1enteev7	317	60	)	)	-RRB-
cord-350836-1enteev7	317	61	.	.	.
cord-350836-1enteev7	318	1	There	there	EX
cord-350836-1enteev7	318	2	are	be	VBP
cord-350836-1enteev7	318	3	many	many	JJ
cord-350836-1enteev7	318	4	mechanisms	mechanism	NNS
cord-350836-1enteev7	318	5	viruses	virus	NNS
cord-350836-1enteev7	318	6	have	have	VBP
cord-350836-1enteev7	318	7	evolved	evolve	VBN
cord-350836-1enteev7	318	8	to	to	TO
cord-350836-1enteev7	318	9	evade	evade	VB
cord-350836-1enteev7	318	10	RIG	rig	NN
cord-350836-1enteev7	318	11	-	-	:
cord-350836-1enteev7	318	12	I	I	NNP
cord-350836-1enteev7	318	13	and	and	CC
cord-350836-1enteev7	318	14	MDA5	MDA5	NNP
cord-350836-1enteev7	318	15	signaling	signaling	NN
cord-350836-1enteev7	318	16	,	,	,
cord-350836-1enteev7	318	17	which	which	WDT
cord-350836-1enteev7	318	18	have	have	VBP
cord-350836-1enteev7	318	19	been	be	VBN
cord-350836-1enteev7	318	20	discussed	discuss	VBN
cord-350836-1enteev7	318	21	at	at	IN
cord-350836-1enteev7	318	22	length	length	NN
cord-350836-1enteev7	318	23	elsewhere	elsewhere	RB
cord-350836-1enteev7	318	24	(	(	-LRB-
cord-350836-1enteev7	318	25	257	257	CD
cord-350836-1enteev7	318	26	,	,	,
cord-350836-1enteev7	318	27	258	258	CD
cord-350836-1enteev7	318	28	)	)	-RRB-
cord-350836-1enteev7	318	29	.	.	.
cord-350836-1enteev7	319	1	Such	such	JJ
cord-350836-1enteev7	319	2	mechanisms	mechanism	NNS
cord-350836-1enteev7	319	3	are	be	VBP
cord-350836-1enteev7	319	4	of	of	IN
cord-350836-1enteev7	319	5	particular	particular	JJ
cord-350836-1enteev7	319	6	importance	importance	NN
cord-350836-1enteev7	319	7	to	to	IN
cord-350836-1enteev7	319	8	segmented	segmented	JJ
cord-350836-1enteev7	319	9	RNA	RNA	NNP
cord-350836-1enteev7	319	10	viruses	virus	NNS
cord-350836-1enteev7	319	11	,	,	,
cord-350836-1enteev7	319	12	providing	provide	VBG
cord-350836-1enteev7	319	13	potentially	potentially	RB
cord-350836-1enteev7	319	14	more	more	JJR
cord-350836-1enteev7	319	15	dsRNAs	dsRNAs	NNP
cord-350836-1enteev7	319	16	for	for	IN
cord-350836-1enteev7	319	17	RIG	rig	NN
cord-350836-1enteev7	319	18	-	-	:
cord-350836-1enteev7	319	19	I	I	NNP
cord-350836-1enteev7	319	20	and	and	CC
cord-350836-1enteev7	319	21	MDA5	MDA5	NNP
cord-350836-1enteev7	319	22	activation	activation	NN
cord-350836-1enteev7	319	23	(	(	-LRB-
cord-350836-1enteev7	319	24	259	259	CD
cord-350836-1enteev7	319	25	)	)	-RRB-
cord-350836-1enteev7	319	26	.	.	.
cord-350836-1enteev7	320	1	IAV	IAV	NNP
cord-350836-1enteev7	320	2	and	and	CC
cord-350836-1enteev7	320	3	the	the	DT
cord-350836-1enteev7	320	4	other	other	JJ
cord-350836-1enteev7	320	5	orthomyxoviruses	orthomyxovirus	NNS
cord-350836-1enteev7	320	6	are	be	VBP
cord-350836-1enteev7	320	7	unique	unique	JJ
cord-350836-1enteev7	320	8	in	in	IN
cord-350836-1enteev7	320	9	that	that	IN
cord-350836-1enteev7	320	10	they	-PRON-	PRP
cord-350836-1enteev7	320	11	replicate	replicate	VBP
cord-350836-1enteev7	320	12	in	in	IN
cord-350836-1enteev7	320	13	the	the	DT
cord-350836-1enteev7	320	14	nucleus	nucleus	NN
cord-350836-1enteev7	320	15	of	of	IN
cord-350836-1enteev7	320	16	the	the	DT
cord-350836-1enteev7	320	17	cells	cell	NNS
cord-350836-1enteev7	320	18	(	(	-LRB-
cord-350836-1enteev7	320	19	260	260	CD
cord-350836-1enteev7	320	20	)	)	-RRB-
cord-350836-1enteev7	320	21	,	,	,
cord-350836-1enteev7	320	22	preventing	prevent	VBG
cord-350836-1enteev7	320	23	the	the	DT
cord-350836-1enteev7	320	24	viral	viral	JJ
cord-350836-1enteev7	320	25	RNA	RNA	NNP
cord-350836-1enteev7	320	26	from	from	IN
cord-350836-1enteev7	320	27	being	be	VBG
cord-350836-1enteev7	320	28	detected	detect	VBN
cord-350836-1enteev7	320	29	by	by	IN
cord-350836-1enteev7	320	30	the	the	DT
cord-350836-1enteev7	320	31	PRRs	prr	NNS
cord-350836-1enteev7	320	32	.	.	.
cord-350836-1enteev7	321	1	However	however	RB
cord-350836-1enteev7	321	2	,	,	,
cord-350836-1enteev7	321	3	recent	recent	JJ
cord-350836-1enteev7	321	4	preliminary	preliminary	JJ
cord-350836-1enteev7	321	5	evidence	evidence	NN
cord-350836-1enteev7	321	6	seems	seem	VBZ
cord-350836-1enteev7	321	7	to	to	TO
cord-350836-1enteev7	321	8	suggest	suggest	VB
cord-350836-1enteev7	321	9	that	that	IN
cord-350836-1enteev7	321	10	RIG	rig	NN
cord-350836-1enteev7	321	11	-	-	:
cord-350836-1enteev7	321	12	I	-PRON-	PRP
cord-350836-1enteev7	321	13	may	may	MD
cord-350836-1enteev7	321	14	also	also	RB
cord-350836-1enteev7	321	15	endogenously	endogenously	RB
cord-350836-1enteev7	321	16	be	be	VB
cord-350836-1enteev7	321	17	present	present	JJ
cord-350836-1enteev7	321	18	in	in	IN
cord-350836-1enteev7	321	19	the	the	DT
cord-350836-1enteev7	321	20	nucleus	nucleus	NN
cord-350836-1enteev7	321	21	and	and	CC
cord-350836-1enteev7	321	22	performs	perform	VBZ
cord-350836-1enteev7	321	23	similar	similar	JJ
cord-350836-1enteev7	321	24	viral	viral	JJ
cord-350836-1enteev7	321	25	RNA	rna	NN
cord-350836-1enteev7	321	26	binding	binding	NN
cord-350836-1enteev7	321	27	and	and	CC
cord-350836-1enteev7	321	28	activation	activation	NN
cord-350836-1enteev7	321	29	of	of	IN
cord-350836-1enteev7	321	30	the	the	DT
cord-350836-1enteev7	321	31	IFN1	IFN1	NNP
cord-350836-1enteev7	321	32	pathway	pathway	NN
cord-350836-1enteev7	321	33	(	(	-LRB-
cord-350836-1enteev7	321	34	261	261	CD
cord-350836-1enteev7	321	35	)	)	-RRB-
cord-350836-1enteev7	321	36	,	,	,
cord-350836-1enteev7	321	37	yet	yet	CC
cord-350836-1enteev7	321	38	this	this	DT
cord-350836-1enteev7	321	39	finding	finding	NN
cord-350836-1enteev7	321	40	has	have	VBZ
cord-350836-1enteev7	321	41	yet	yet	RB
cord-350836-1enteev7	321	42	to	to	TO
cord-350836-1enteev7	321	43	be	be	VB
cord-350836-1enteev7	321	44	replicated	replicate	VBN
cord-350836-1enteev7	321	45	by	by	IN
cord-350836-1enteev7	321	46	other	other	JJ
cord-350836-1enteev7	321	47	laboratories	laboratory	NNS
cord-350836-1enteev7	321	48	.	.	.
cord-350836-1enteev7	322	1	There	there	EX
cord-350836-1enteev7	322	2	is	be	VBZ
cord-350836-1enteev7	322	3	also	also	RB
cord-350836-1enteev7	322	4	increasing	increase	VBG
cord-350836-1enteev7	322	5	evidence	evidence	NN
cord-350836-1enteev7	322	6	to	to	TO
cord-350836-1enteev7	322	7	suggest	suggest	VB
cord-350836-1enteev7	322	8	that	that	IN
cord-350836-1enteev7	322	9	RNA	RNA	NNP
cord-350836-1enteev7	322	10	processing	processing	NN
cord-350836-1enteev7	322	11	is	be	VBZ
cord-350836-1enteev7	322	12	another	another	DT
cord-350836-1enteev7	322	13	mechanism	mechanism	NN
cord-350836-1enteev7	322	14	of	of	IN
cord-350836-1enteev7	322	15	immune	immune	JJ
cord-350836-1enteev7	322	16	modulation	modulation	NN
cord-350836-1enteev7	322	17	.	.	.
cord-350836-1enteev7	323	1	Certain	certain	JJ
cord-350836-1enteev7	323	2	bunyaviruses	bunyavirus	NNS
cord-350836-1enteev7	323	3	can	can	MD
cord-350836-1enteev7	323	4	cleave	cleave	VB
cord-350836-1enteev7	323	5	the	the	DT
cord-350836-1enteev7	323	6	5	5	CD
cord-350836-1enteev7	323	7	′	′	CD
cord-350836-1enteev7	323	8	tri	tri	JJ
cord-350836-1enteev7	323	9	-	-	JJ
cord-350836-1enteev7	323	10	phosphate	phosphate	JJ
cord-350836-1enteev7	323	11	group	group	NN
cord-350836-1enteev7	323	12	from	from	IN
cord-350836-1enteev7	323	13	their	-PRON-	PRP$
cord-350836-1enteev7	323	14	genomic	genomic	JJ
cord-350836-1enteev7	323	15	RNA	RNA	NNP
cord-350836-1enteev7	323	16	(	(	-LRB-
cord-350836-1enteev7	323	17	262	262	CD
cord-350836-1enteev7	323	18	)	)	-RRB-
cord-350836-1enteev7	323	19	in	in	IN
cord-350836-1enteev7	323	20	order	order	NN
cord-350836-1enteev7	323	21	to	to	TO
cord-350836-1enteev7	323	22	avoid	avoid	VB
cord-350836-1enteev7	323	23	immune	immune	JJ
cord-350836-1enteev7	323	24	detection	detection	NN
cord-350836-1enteev7	323	25	.	.	.
cord-350836-1enteev7	324	1	RIG	rig	NN
cord-350836-1enteev7	324	2	-	-	:
cord-350836-1enteev7	324	3	I	-PRON-	PRP
cord-350836-1enteev7	324	4	has	have	VBZ
cord-350836-1enteev7	324	5	also	also	RB
cord-350836-1enteev7	324	6	been	be	VBN
cord-350836-1enteev7	324	7	found	find	VBN
cord-350836-1enteev7	324	8	to	to	TO
cord-350836-1enteev7	324	9	be	be	VB
cord-350836-1enteev7	324	10	subjected	subject	VBN
cord-350836-1enteev7	324	11	to	to	IN
cord-350836-1enteev7	324	12	negative	negative	JJ
cord-350836-1enteev7	324	13	modulation	modulation	NN
cord-350836-1enteev7	324	14	by	by	IN
cord-350836-1enteev7	324	15	RNAi	RNAi	NNS
cord-350836-1enteev7	324	16	during	during	IN
cord-350836-1enteev7	324	17	IAV	IAV	NNP
cord-350836-1enteev7	324	18	infection	infection	NN
cord-350836-1enteev7	324	19	(	(	-LRB-
cord-350836-1enteev7	324	20	263	263	CD
cord-350836-1enteev7	324	21	)	)	-RRB-
cord-350836-1enteev7	324	22	.	.	.
cord-350836-1enteev7	325	1	On	on	IN
cord-350836-1enteev7	325	2	the	the	DT
cord-350836-1enteev7	325	3	contrary	contrary	NN
cord-350836-1enteev7	325	4	,	,	,
cord-350836-1enteev7	325	5	nucleoproteins	nucleoprotein	NNS
cord-350836-1enteev7	325	6	from	from	IN
cord-350836-1enteev7	325	7	the	the	DT
cord-350836-1enteev7	325	8	Sendai	Sendai	NNP
cord-350836-1enteev7	325	9	virus	virus	NN
cord-350836-1enteev7	325	10	(	(	-LRB-
cord-350836-1enteev7	325	11	264	264	CD
cord-350836-1enteev7	325	12	)	)	-RRB-
cord-350836-1enteev7	325	13	regulate	regulate	VBP
cord-350836-1enteev7	325	14	the	the	DT
cord-350836-1enteev7	325	15	number	number	NN
cord-350836-1enteev7	325	16	of	of	IN
cord-350836-1enteev7	325	17	DI	DI	NNP
cord-350836-1enteev7	325	18	particles	particle	NNS
cord-350836-1enteev7	325	19	being	be	VBG
cord-350836-1enteev7	325	20	produced	produce	VBN
cord-350836-1enteev7	325	21	,	,	,
cord-350836-1enteev7	325	22	and	and	CC
cord-350836-1enteev7	325	23	IAV	IAV	NNP
cord-350836-1enteev7	325	24	nucleoproteins	nucleoprotein	NNS
cord-350836-1enteev7	325	25	also	also	RB
cord-350836-1enteev7	325	26	regulate	regulate	VBP
cord-350836-1enteev7	325	27	the	the	DT
cord-350836-1enteev7	325	28	production	production	NN
cord-350836-1enteev7	325	29	of	of	IN
cord-350836-1enteev7	325	30	abortive	abortive	JJ
cord-350836-1enteev7	325	31	replication	replication	NN
cord-350836-1enteev7	325	32	RNA	RNA	NNP
cord-350836-1enteev7	325	33	(	(	-LRB-
cord-350836-1enteev7	325	34	208	208	CD
cord-350836-1enteev7	325	35	)	)	-RRB-
cord-350836-1enteev7	325	36	,	,	,
cord-350836-1enteev7	325	37	mini	mini	JJ
cord-350836-1enteev7	325	38	viral	viral	JJ
cord-350836-1enteev7	325	39	RNAs	rna	NNS
cord-350836-1enteev7	325	40	(	(	-LRB-
cord-350836-1enteev7	325	41	265	265	CD
cord-350836-1enteev7	325	42	)	)	-RRB-
cord-350836-1enteev7	325	43	and	and	CC
cord-350836-1enteev7	325	44	DVG	DVG	NNP
cord-350836-1enteev7	325	45	RNA	RNA	NNP
cord-350836-1enteev7	325	46	(	(	-LRB-
cord-350836-1enteev7	325	47	208	208	CD
cord-350836-1enteev7	325	48	)	)	-RRB-
cord-350836-1enteev7	325	49	,	,	,
cord-350836-1enteev7	325	50	all	all	DT
cord-350836-1enteev7	325	51	of	of	IN
cord-350836-1enteev7	325	52	which	which	WDT
cord-350836-1enteev7	325	53	are	be	VBP
cord-350836-1enteev7	325	54	immunostimulatory	immunostimulatory	JJ
cord-350836-1enteev7	325	55	.	.	.
cord-350836-1enteev7	326	1	The	the	DT
cord-350836-1enteev7	326	2	Semliki	Semliki	NNP
cord-350836-1enteev7	326	3	Forest	Forest	NNP
cord-350836-1enteev7	326	4	virus	virus	NN
cord-350836-1enteev7	326	5	(	(	-LRB-
cord-350836-1enteev7	326	6	SFV	SFV	NNP
cord-350836-1enteev7	326	7	)	)	-RRB-
cord-350836-1enteev7	326	8	polymerase	polymerase	NN
cord-350836-1enteev7	326	9	has	have	VBZ
cord-350836-1enteev7	326	10	even	even	RB
cord-350836-1enteev7	326	11	been	be	VBN
cord-350836-1enteev7	326	12	found	find	VBN
cord-350836-1enteev7	326	13	to	to	TO
cord-350836-1enteev7	326	14	convert	convert	VB
cord-350836-1enteev7	326	15	host	host	NN
cord-350836-1enteev7	326	16	RNA	RNA	NNP
cord-350836-1enteev7	326	17	into	into	IN
cord-350836-1enteev7	326	18	5	5	CD
cord-350836-1enteev7	326	19	′	′	CD
cord-350836-1enteev7	327	1	-ppp	-ppp	:
cord-350836-1enteev7	327	2	dsRNA	dsrna	NN
cord-350836-1enteev7	328	1	to	to	TO
cord-350836-1enteev7	328	2	induce	induce	VB
cord-350836-1enteev7	328	3	IFN1	IFN1	NNP
cord-350836-1enteev7	328	4	expression	expression	NN
cord-350836-1enteev7	328	5	(	(	-LRB-
cord-350836-1enteev7	328	6	266	266	CD
cord-350836-1enteev7	328	7	)	)	-RRB-
cord-350836-1enteev7	328	8	.	.	.
cord-350836-1enteev7	329	1	This	this	DT
cord-350836-1enteev7	329	2	raises	raise	VBZ
cord-350836-1enteev7	329	3	an	an	DT
cord-350836-1enteev7	329	4	intriguing	intriguing	JJ
cord-350836-1enteev7	329	5	possibility	possibility	NN
cord-350836-1enteev7	329	6	that	that	IN
cord-350836-1enteev7	329	7	induction	induction	NN
cord-350836-1enteev7	329	8	of	of	IN
cord-350836-1enteev7	329	9	IFN1	IFN1	NNP
cord-350836-1enteev7	329	10	may	may	MD
cord-350836-1enteev7	329	11	actually	actually	RB
cord-350836-1enteev7	329	12	benefit	benefit	VB
cord-350836-1enteev7	329	13	some	some	DT
cord-350836-1enteev7	329	14	viruses	virus	NNS
cord-350836-1enteev7	329	15	under	under	IN
cord-350836-1enteev7	329	16	certain	certain	JJ
cord-350836-1enteev7	329	17	circumstances	circumstance	NNS
cord-350836-1enteev7	329	18	despite	despite	IN
cord-350836-1enteev7	329	19	IFN1	IFN1	NNP
cord-350836-1enteev7	329	20	signaling	signal	VBG
cord-350836-1enteev7	329	21	negatively	negatively	RB
cord-350836-1enteev7	329	22	regulating	regulate	VBG
cord-350836-1enteev7	329	23	viral	viral	JJ
cord-350836-1enteev7	329	24	replication	replication	NN
cord-350836-1enteev7	329	25	.	.	.
cord-350836-1enteev7	330	1	The	the	DT
cord-350836-1enteev7	330	2	viral	viral	JJ
cord-350836-1enteev7	330	3	RNA	RNA	NNP
cord-350836-1enteev7	330	4	levels	level	NNS
cord-350836-1enteev7	330	5	and	and	CC
cord-350836-1enteev7	330	6	localization	localization	NN
cord-350836-1enteev7	330	7	throughout	throughout	IN
cord-350836-1enteev7	330	8	the	the	DT
cord-350836-1enteev7	330	9	viral	viral	JJ
cord-350836-1enteev7	330	10	life	life	NN
cord-350836-1enteev7	330	11	cycle	cycle	NN
cord-350836-1enteev7	330	12	might	may	MD
cord-350836-1enteev7	330	13	also	also	RB
cord-350836-1enteev7	330	14	play	play	VB
cord-350836-1enteev7	330	15	an	an	DT
cord-350836-1enteev7	330	16	important	important	JJ
cord-350836-1enteev7	330	17	role	role	NN
cord-350836-1enteev7	330	18	in	in	IN
cord-350836-1enteev7	330	19	immune	immune	JJ
cord-350836-1enteev7	330	20	evasion	evasion	NN
cord-350836-1enteev7	330	21	(	(	-LRB-
cord-350836-1enteev7	330	22	267	267	CD
cord-350836-1enteev7	330	23	)	)	-RRB-
cord-350836-1enteev7	330	24	.	.	.
cord-350836-1enteev7	331	1	Control	control	NN
cord-350836-1enteev7	331	2	of	of	IN
cord-350836-1enteev7	331	3	viral	viral	JJ
cord-350836-1enteev7	331	4	RNA	RNA	NNP
cord-350836-1enteev7	331	5	levels	level	NNS
cord-350836-1enteev7	331	6	by	by	IN
cord-350836-1enteev7	331	7	viral	viral	JJ
cord-350836-1enteev7	331	8	exoribonucleases	exoribonuclease	NNS
cord-350836-1enteev7	331	9	in	in	IN
cord-350836-1enteev7	331	10	particular	particular	JJ
cord-350836-1enteev7	331	11	illustrates	illustrate	VBZ
cord-350836-1enteev7	331	12	the	the	DT
cord-350836-1enteev7	331	13	complicated	complicated	JJ
cord-350836-1enteev7	331	14	balance	balance	NN
cord-350836-1enteev7	331	15	between	between	IN
cord-350836-1enteev7	331	16	viral	viral	JJ
cord-350836-1enteev7	331	17	production	production	NN
cord-350836-1enteev7	331	18	and	and	CC
cord-350836-1enteev7	331	19	immune	immune	JJ
cord-350836-1enteev7	331	20	evasion	evasion	NN
cord-350836-1enteev7	331	21	for	for	IN
cord-350836-1enteev7	331	22	optimal	optimal	JJ
cord-350836-1enteev7	331	23	viral	viral	JJ
cord-350836-1enteev7	331	24	propagation	propagation	NN
cord-350836-1enteev7	331	25	,	,	,
cord-350836-1enteev7	331	26	as	as	IN
cord-350836-1enteev7	331	27	has	have	VBZ
cord-350836-1enteev7	331	28	found	find	VBN
cord-350836-1enteev7	331	29	to	to	TO
cord-350836-1enteev7	331	30	be	be	VB
cord-350836-1enteev7	331	31	the	the	DT
cord-350836-1enteev7	331	32	case	case	NN
cord-350836-1enteev7	331	33	for	for	IN
cord-350836-1enteev7	331	34	arenaviral	arenaviral	NNP
cord-350836-1enteev7	331	35	nucleoproteins	nucleoproteins	NNP
cord-350836-1enteev7	331	36	(	(	-LRB-
cord-350836-1enteev7	331	37	NPs	NPs	NNP
cord-350836-1enteev7	331	38	)	)	-RRB-
cord-350836-1enteev7	331	39	(	(	-LRB-
cord-350836-1enteev7	331	40	268	268	CD
cord-350836-1enteev7	331	41	,	,	,
cord-350836-1enteev7	331	42	269	269	CD
cord-350836-1enteev7	331	43	)	)	-RRB-
cord-350836-1enteev7	331	44	and	and	CC
cord-350836-1enteev7	331	45	nonstructural	nonstructural	JJ
cord-350836-1enteev7	331	46	proteins	protein	NNS
cord-350836-1enteev7	331	47	found	find	VBN
cord-350836-1enteev7	331	48	in	in	IN
cord-350836-1enteev7	331	49	coronaviruses	coronaviruse	NNS
cord-350836-1enteev7	331	50	(	(	-LRB-
cord-350836-1enteev7	331	51	270	270	CD
cord-350836-1enteev7	331	52	,	,	,
cord-350836-1enteev7	331	53	271	271	CD
cord-350836-1enteev7	331	54	)	)	-RRB-
cord-350836-1enteev7	331	55	.	.	.
cord-350836-1enteev7	332	1	Finally	finally	RB
cord-350836-1enteev7	332	2	,	,	,
cord-350836-1enteev7	332	3	viral	viral	JJ
cord-350836-1enteev7	332	4	infection	infection	NN
cord-350836-1enteev7	332	5	has	have	VBZ
cord-350836-1enteev7	332	6	the	the	DT
cord-350836-1enteev7	332	7	capability	capability	NN
cord-350836-1enteev7	332	8	to	to	TO
cord-350836-1enteev7	332	9	disrupt	disrupt	VB
cord-350836-1enteev7	332	10	processes	process	NNS
cord-350836-1enteev7	332	11	of	of	IN
cord-350836-1enteev7	332	12	the	the	DT
cord-350836-1enteev7	332	13	cell	cell	NN
cord-350836-1enteev7	332	14	's	's	POS
cord-350836-1enteev7	332	15	basic	basic	JJ
cord-350836-1enteev7	332	16	functions	function	NNS
cord-350836-1enteev7	332	17	,	,	,
cord-350836-1enteev7	332	18	such	such	JJ
cord-350836-1enteev7	332	19	as	as	IN
cord-350836-1enteev7	332	20	transcription	transcription	NN
cord-350836-1enteev7	332	21	and	and	CC
cord-350836-1enteev7	332	22	translation	translation	NN
cord-350836-1enteev7	332	23	,	,	,
cord-350836-1enteev7	332	24	thereby	thereby	RB
cord-350836-1enteev7	332	25	affecting	affect	VBG
cord-350836-1enteev7	332	26	viral	viral	JJ
cord-350836-1enteev7	332	27	replication	replication	NN
cord-350836-1enteev7	332	28	and	and	CC
cord-350836-1enteev7	332	29	immune	immune	JJ
cord-350836-1enteev7	332	30	signaling	signaling	NN
cord-350836-1enteev7	332	31	in	in	IN
cord-350836-1enteev7	332	32	complicated	complicated	JJ
cord-350836-1enteev7	332	33	ways	way	NNS
cord-350836-1enteev7	332	34	(	(	-LRB-
cord-350836-1enteev7	332	35	258	258	CD
cord-350836-1enteev7	332	36	)	)	-RRB-
cord-350836-1enteev7	332	37	.	.	.
cord-350836-1enteev7	333	1	One	one	CD
cord-350836-1enteev7	333	2	of	of	IN
cord-350836-1enteev7	333	3	the	the	DT
cord-350836-1enteev7	333	4	most	most	RBS
cord-350836-1enteev7	333	5	significant	significant	JJ
cord-350836-1enteev7	333	6	ways	way	NNS
cord-350836-1enteev7	333	7	viruses	virus	NNS
cord-350836-1enteev7	333	8	modulate	modulate	VBP
cord-350836-1enteev7	333	9	RIG	rig	NN
cord-350836-1enteev7	333	10	-	-	:
cord-350836-1enteev7	333	11	I	I	NNP
cord-350836-1enteev7	333	12	and	and	CC
cord-350836-1enteev7	333	13	MDA5	MDA5	NNP
cord-350836-1enteev7	333	14	signaling	signal	VBG
cord-350836-1enteev7	333	15	is	be	VBZ
cord-350836-1enteev7	333	16	through	through	IN
cord-350836-1enteev7	333	17	their	-PRON-	PRP$
cord-350836-1enteev7	333	18	viral	viral	JJ
cord-350836-1enteev7	333	19	proteins	protein	NNS
cord-350836-1enteev7	333	20	(	(	-LRB-
cord-350836-1enteev7	333	21	272	272	CD
cord-350836-1enteev7	333	22	)	)	-RRB-
cord-350836-1enteev7	334	1	(	(	-LRB-
cord-350836-1enteev7	334	2	Figure	figure	NN
cord-350836-1enteev7	334	3	6	6	CD
cord-350836-1enteev7	334	4	)	)	-RRB-
cord-350836-1enteev7	334	5	.	.	.
cord-350836-1enteev7	335	1	The	the	DT
cord-350836-1enteev7	335	2	respiratory	respiratory	JJ
cord-350836-1enteev7	335	3	syncytial	syncytial	JJ
cord-350836-1enteev7	335	4	virus	virus	NN
cord-350836-1enteev7	335	5	(	(	-LRB-
cord-350836-1enteev7	335	6	RSV	RSV	NNP
cord-350836-1enteev7	335	7	)	)	-RRB-
cord-350836-1enteev7	335	8	non	non	JJ
cord-350836-1enteev7	335	9	-	-	JJ
cord-350836-1enteev7	335	10	structural	structural	JJ
cord-350836-1enteev7	335	11	protein	protein	NN
cord-350836-1enteev7	335	12	(	(	-LRB-
cord-350836-1enteev7	335	13	NS2	NS2	NNP
cord-350836-1enteev7	335	14	)	)	-RRB-
cord-350836-1enteev7	335	15	protein	protein	NN
cord-350836-1enteev7	335	16	and	and	CC
cord-350836-1enteev7	335	17	the	the	DT
cord-350836-1enteev7	335	18	Z	z	NN
cord-350836-1enteev7	335	19	matrix	matrix	NN
cord-350836-1enteev7	335	20	proteins	protein	NNS
cord-350836-1enteev7	335	21	of	of	IN
cord-350836-1enteev7	335	22	pathogenic	pathogenic	JJ
cord-350836-1enteev7	335	23	arenaviruses	arenavirus	NNS
cord-350836-1enteev7	335	24	interact	interact	VB
cord-350836-1enteev7	335	25	with	with	IN
cord-350836-1enteev7	335	26	the	the	DT
cord-350836-1enteev7	335	27	RIG-	RIG-	NNP
cord-350836-1enteev7	336	1	I	-PRON-	PRP
cord-350836-1enteev7	336	2	CARD	card	VBP
cord-350836-1enteev7	336	3	domains	domain	NNS
cord-350836-1enteev7	336	4	to	to	TO
cord-350836-1enteev7	336	5	block	block	VB
cord-350836-1enteev7	336	6	its	-PRON-	PRP$
cord-350836-1enteev7	336	7	interaction	interaction	NN
cord-350836-1enteev7	336	8	with	with	IN
cord-350836-1enteev7	336	9	MAVS	MAVS	NNPS
cord-350836-1enteev7	336	10	(	(	-LRB-
cord-350836-1enteev7	336	11	273	273	CD
cord-350836-1enteev7	336	12	,	,	,
cord-350836-1enteev7	336	13	274	274	CD
cord-350836-1enteev7	336	14	)	)	-RRB-
cord-350836-1enteev7	336	15	.	.	.
cord-350836-1enteev7	337	1	The	the	DT
cord-350836-1enteev7	337	2	HSV1	HSV1	NNP
cord-350836-1enteev7	337	3	deamidase	deamidase	NN
cord-350836-1enteev7	338	1	UL37	UL37	NNP
cord-350836-1enteev7	338	2	specifically	specifically	RB
cord-350836-1enteev7	338	3	targets	target	VBZ
cord-350836-1enteev7	338	4	RIG	rig	NN
cord-350836-1enteev7	338	5	-	-	:
cord-350836-1enteev7	338	6	I	-PRON-	PRP
cord-350836-1enteev7	338	7	through	through	IN
cord-350836-1enteev7	338	8	its	-PRON-	PRP$
cord-350836-1enteev7	338	9	helicase	helicase	NN
cord-350836-1enteev7	338	10	domain	domain	NN
cord-350836-1enteev7	338	11	,	,	,
cord-350836-1enteev7	338	12	abrogating	abrogate	VBG
cord-350836-1enteev7	338	13	its	-PRON-	PRP$
cord-350836-1enteev7	338	14	ability	ability	NN
cord-350836-1enteev7	338	15	to	to	TO
cord-350836-1enteev7	338	16	bind	bind	VB
cord-350836-1enteev7	338	17	to	to	IN
cord-350836-1enteev7	338	18	RNA	RNA	NNP
cord-350836-1enteev7	338	19	(	(	-LRB-
cord-350836-1enteev7	338	20	275	275	CD
cord-350836-1enteev7	338	21	)	)	-RRB-
cord-350836-1enteev7	338	22	.	.	.
cord-350836-1enteev7	339	1	The	the	DT
cord-350836-1enteev7	339	2	IAV	IAV	NNP
cord-350836-1enteev7	339	3	polymerase	polymerase	NN
cord-350836-1enteev7	339	4	components	component	NNS
cord-350836-1enteev7	339	5	also	also	RB
cord-350836-1enteev7	339	6	interact	interact	VBP
cord-350836-1enteev7	339	7	directly	directly	RB
cord-350836-1enteev7	339	8	with	with	IN
cord-350836-1enteev7	339	9	RIG	rig	NN
cord-350836-1enteev7	339	10	-	-	:
cord-350836-1enteev7	339	11	I	i	NN
cord-350836-1enteev7	339	12	(	(	-LRB-
cord-350836-1enteev7	339	13	276	276	CD
cord-350836-1enteev7	339	14	)	)	-RRB-
cord-350836-1enteev7	339	15	,	,	,
cord-350836-1enteev7	339	16	though	though	IN
cord-350836-1enteev7	339	17	their	-PRON-	PRP$
cord-350836-1enteev7	339	18	biological	biological	JJ
cord-350836-1enteev7	339	19	significance	significance	NN
cord-350836-1enteev7	339	20	has	have	VBZ
cord-350836-1enteev7	339	21	yet	yet	RB
cord-350836-1enteev7	339	22	to	to	TO
cord-350836-1enteev7	339	23	be	be	VB
cord-350836-1enteev7	339	24	determined	determine	VBN
cord-350836-1enteev7	339	25	as	as	IN
cord-350836-1enteev7	339	26	they	-PRON-	PRP
cord-350836-1enteev7	339	27	do	do	VBP
cord-350836-1enteev7	339	28	n't	not	RB
cord-350836-1enteev7	339	29	significantly	significantly	RB
cord-350836-1enteev7	339	30	affect	affect	VB
cord-350836-1enteev7	339	31	IFN1	ifn1	JJ
cord-350836-1enteev7	339	32	production	production	NN
cord-350836-1enteev7	339	33	.	.	.
cord-350836-1enteev7	340	1	On	on	IN
cord-350836-1enteev7	340	2	the	the	DT
cord-350836-1enteev7	340	3	other	other	JJ
cord-350836-1enteev7	340	4	hand	hand	NN
cord-350836-1enteev7	340	5	,	,	,
cord-350836-1enteev7	340	6	RNA	RNA	NNP
cord-350836-1enteev7	340	7	binding	binding	NN
cord-350836-1enteev7	340	8	appears	appear	VBZ
cord-350836-1enteev7	340	9	to	to	TO
cord-350836-1enteev7	340	10	be	be	VB
cord-350836-1enteev7	340	11	an	an	DT
cord-350836-1enteev7	340	12	important	important	JJ
cord-350836-1enteev7	340	13	bridge	bridge	NN
cord-350836-1enteev7	340	14	between	between	IN
cord-350836-1enteev7	340	15	the	the	DT
cord-350836-1enteev7	340	16	interaction	interaction	NN
cord-350836-1enteev7	340	17	of	of	IN
cord-350836-1enteev7	340	18	RIG	rig	NN
cord-350836-1enteev7	340	19	-	-	:
cord-350836-1enteev7	340	20	I	-PRON-	PRP
cord-350836-1enteev7	340	21	with	with	IN
cord-350836-1enteev7	340	22	other	other	JJ
cord-350836-1enteev7	340	23	viral	viral	JJ
cord-350836-1enteev7	340	24	proteins	protein	NNS
cord-350836-1enteev7	340	25	,	,	,
cord-350836-1enteev7	340	26	as	as	IN
cord-350836-1enteev7	340	27	the	the	DT
cord-350836-1enteev7	340	28	nucleoproteins	nucleoprotein	NNS
cord-350836-1enteev7	340	29	(	(	-LRB-
cord-350836-1enteev7	340	30	NPs	NPs	NNP
cord-350836-1enteev7	340	31	)	)	-RRB-
cord-350836-1enteev7	340	32	of	of	IN
cord-350836-1enteev7	340	33	IAV	IAV	NNP
cord-350836-1enteev7	340	34	(	(	-LRB-
cord-350836-1enteev7	340	35	276	276	CD
cord-350836-1enteev7	340	36	)	)	-RRB-
cord-350836-1enteev7	340	37	and	and	CC
cord-350836-1enteev7	340	38	arenaviruses	arenaviruses	NNP
cord-350836-1enteev7	340	39	(	(	-LRB-
cord-350836-1enteev7	340	40	277	277	CD
cord-350836-1enteev7	340	41	,	,	,
cord-350836-1enteev7	340	42	278	278	CD
cord-350836-1enteev7	340	43	)	)	-RRB-
cord-350836-1enteev7	341	1	both	both	DT
cord-350836-1enteev7	341	2	interact	interact	VBP
cord-350836-1enteev7	341	3	with	with	IN
cord-350836-1enteev7	341	4	RIG	rig	NN
cord-350836-1enteev7	341	5	-	-	:
cord-350836-1enteev7	341	6	I	-PRON-	PRP
cord-350836-1enteev7	341	7	through	through	IN
cord-350836-1enteev7	341	8	viral	viral	JJ
cord-350836-1enteev7	341	9	RNA	RNA	NNP
cord-350836-1enteev7	341	10	.	.	.
cord-350836-1enteev7	342	1	The	the	DT
cord-350836-1enteev7	342	2	NS1	ns1	NN
cord-350836-1enteev7	342	3	protein	protein	NN
cord-350836-1enteev7	342	4	of	of	IN
cord-350836-1enteev7	342	5	rotaviruses	rotaviruses	NNP
cord-350836-1enteev7	342	6	targets	target	VBZ
cord-350836-1enteev7	342	7	RIG	rig	NN
cord-350836-1enteev7	342	8	-	-	:
cord-350836-1enteev7	342	9	I	-PRON-	PRP
cord-350836-1enteev7	342	10	for	for	IN
cord-350836-1enteev7	342	11	degradation	degradation	NN
cord-350836-1enteev7	342	12	that	that	WDT
cord-350836-1enteev7	342	13	is	be	VBZ
cord-350836-1enteev7	342	14	independent	independent	JJ
cord-350836-1enteev7	342	15	of	of	IN
cord-350836-1enteev7	342	16	proteasomes	proteasomes	NNP
cord-350836-1enteev7	342	17	(	(	-LRB-
cord-350836-1enteev7	342	18	279	279	CD
cord-350836-1enteev7	342	19	)	)	-RRB-
cord-350836-1enteev7	342	20	.	.	.
cord-350836-1enteev7	343	1	The	the	DT
cord-350836-1enteev7	343	2	V	V	NNP
cord-350836-1enteev7	343	3	protein	protein	NN
cord-350836-1enteev7	343	4	of	of	IN
cord-350836-1enteev7	343	5	paramyxoviruses	paramyxovirus	NNS
cord-350836-1enteev7	343	6	inhibits	inhibit	VBZ
cord-350836-1enteev7	343	7	MDA5	MDA5	NNP
cord-350836-1enteev7	343	8	(	(	-LRB-
cord-350836-1enteev7	343	9	40	40	CD
cord-350836-1enteev7	343	10	)	)	-RRB-
cord-350836-1enteev7	343	11	by	by	IN
cord-350836-1enteev7	343	12	targeting	target	VBG
cord-350836-1enteev7	343	13	a	a	DT
cord-350836-1enteev7	343	14	unique	unique	JJ
cord-350836-1enteev7	343	15	feature	feature	NN
cord-350836-1enteev7	343	16	of	of	IN
cord-350836-1enteev7	343	17	the	the	DT
cord-350836-1enteev7	343	18	ATP	ATP	NNP
cord-350836-1enteev7	343	19	binding	binding	NN
cord-350836-1enteev7	343	20	pocket	pocket	NN
cord-350836-1enteev7	343	21	in	in	IN
cord-350836-1enteev7	343	22	MDA5	MDA5	NNP
cord-350836-1enteev7	343	23	(	(	-LRB-
cord-350836-1enteev7	343	24	280	280	CD
cord-350836-1enteev7	343	25	)	)	-RRB-
cord-350836-1enteev7	343	26	and	and	CC
cord-350836-1enteev7	343	27	by	by	IN
cord-350836-1enteev7	343	28	inhibiting	inhibit	VBG
cord-350836-1enteev7	343	29	MDA5	MDA5	NNP
cord-350836-1enteev7	343	30	CARD	card	NN
cord-350836-1enteev7	343	31	dephosphorylation	dephosphorylation	NN
cord-350836-1enteev7	343	32	(	(	-LRB-
cord-350836-1enteev7	343	33	93	93	CD
cord-350836-1enteev7	343	34	)	)	-RRB-
cord-350836-1enteev7	343	35	,	,	,
cord-350836-1enteev7	343	36	but	but	CC
cord-350836-1enteev7	343	37	can	can	MD
cord-350836-1enteev7	343	38	also	also	RB
cord-350836-1enteev7	343	39	inhibit	inhibit	VB
cord-350836-1enteev7	343	40	RIG	rig	NN
cord-350836-1enteev7	343	41	-	-	:
cord-350836-1enteev7	343	42	I	-PRON-	PRP
cord-350836-1enteev7	343	43	by	by	IN
cord-350836-1enteev7	343	44	interacting	interact	VBG
cord-350836-1enteev7	343	45	with	with	IN
cord-350836-1enteev7	343	46	the	the	DT
cord-350836-1enteev7	343	47	CARD	card	NN
cord-350836-1enteev7	343	48	domain	domain	NN
cord-350836-1enteev7	343	49	to	to	TO
cord-350836-1enteev7	343	50	prevent	prevent	VB
cord-350836-1enteev7	343	51	its	-PRON-	PRP$
cord-350836-1enteev7	343	52	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	343	53	by	by	IN
cord-350836-1enteev7	343	54	TRIM25	TRIM25	NNP
cord-350836-1enteev7	343	55	(	(	-LRB-
cord-350836-1enteev7	343	56	281	281	CD
cord-350836-1enteev7	343	57	)	)	-RRB-
cord-350836-1enteev7	343	58	.	.	.
cord-350836-1enteev7	344	1	Finally	finally	RB
cord-350836-1enteev7	344	2	,	,	,
cord-350836-1enteev7	344	3	the	the	DT
cord-350836-1enteev7	344	4	US11	US11	NNP
cord-350836-1enteev7	344	5	protein	protein	NN
cord-350836-1enteev7	344	6	of	of	IN
cord-350836-1enteev7	344	7	HSV1	HSV1	NNP
cord-350836-1enteev7	344	8	(	(	-LRB-
cord-350836-1enteev7	344	9	282	282	CD
cord-350836-1enteev7	344	10	)	)	-RRB-
cord-350836-1enteev7	344	11	and	and	CC
cord-350836-1enteev7	344	12	the	the	DT
cord-350836-1enteev7	344	13	arenaviral	arenaviral	NNP
cord-350836-1enteev7	344	14	Z	Z	NNP
cord-350836-1enteev7	344	15	matrix	matrix	NN
cord-350836-1enteev7	344	16	proteins	protein	NNS
cord-350836-1enteev7	344	17	(	(	-LRB-
cord-350836-1enteev7	344	18	274	274	CD
cord-350836-1enteev7	344	19	)	)	-RRB-
cord-350836-1enteev7	344	20	directly	directly	RB
cord-350836-1enteev7	344	21	interact	interact	VB
cord-350836-1enteev7	344	22	with	with	IN
cord-350836-1enteev7	344	23	and	and	CC
cord-350836-1enteev7	344	24	inhibit	inhibit	VB
cord-350836-1enteev7	344	25	RIG	rig	NN
cord-350836-1enteev7	344	26	-	-	:
cord-350836-1enteev7	344	27	I	I	NNP
cord-350836-1enteev7	344	28	and	and	CC
cord-350836-1enteev7	344	29	MDA5	MDA5	NNP
cord-350836-1enteev7	344	30	in	in	IN
cord-350836-1enteev7	344	31	a	a	DT
cord-350836-1enteev7	344	32	similar	similar	JJ
cord-350836-1enteev7	344	33	fashion	fashion	NN
cord-350836-1enteev7	344	34	.	.	.
cord-350836-1enteev7	345	1	There	there	EX
cord-350836-1enteev7	345	2	are	be	VBP
cord-350836-1enteev7	345	3	also	also	RB
cord-350836-1enteev7	345	4	many	many	JJ
cord-350836-1enteev7	345	5	other	other	JJ
cord-350836-1enteev7	345	6	viral	viral	JJ
cord-350836-1enteev7	345	7	proteins	protein	NNS
cord-350836-1enteev7	345	8	that	that	WDT
cord-350836-1enteev7	345	9	can	can	MD
cord-350836-1enteev7	345	10	regulate	regulate	VB
cord-350836-1enteev7	345	11	proteins	protein	NNS
cord-350836-1enteev7	345	12	in	in	IN
cord-350836-1enteev7	345	13	the	the	DT
cord-350836-1enteev7	345	14	RIG	rig	NN
cord-350836-1enteev7	345	15	-	-	:
cord-350836-1enteev7	345	16	I	I	NNP
cord-350836-1enteev7	345	17	and	and	CC
cord-350836-1enteev7	345	18	MDA5	mda5	JJ
cord-350836-1enteev7	345	19	pathways	pathway	NNS
cord-350836-1enteev7	345	20	,	,	,
cord-350836-1enteev7	345	21	which	which	WDT
cord-350836-1enteev7	345	22	have	have	VBP
cord-350836-1enteev7	345	23	been	be	VBN
cord-350836-1enteev7	345	24	discussed	discuss	VBN
cord-350836-1enteev7	345	25	in	in	IN
cord-350836-1enteev7	345	26	detail	detail	NN
cord-350836-1enteev7	345	27	elsewhere	elsewhere	RB
cord-350836-1enteev7	345	28	(	(	-LRB-
cord-350836-1enteev7	345	29	44	44	CD
cord-350836-1enteev7	345	30	,	,	,
cord-350836-1enteev7	345	31	53	53	CD
cord-350836-1enteev7	345	32	,	,	,
cord-350836-1enteev7	345	33	59	59	CD
cord-350836-1enteev7	345	34	,	,	,
cord-350836-1enteev7	345	35	96	96	CD
cord-350836-1enteev7	345	36	,	,	,
cord-350836-1enteev7	345	37	257	257	CD
cord-350836-1enteev7	345	38	,	,	,
cord-350836-1enteev7	345	39	283	283	CD
cord-350836-1enteev7	345	40	)	)	-RRB-
cord-350836-1enteev7	345	41	.	.	.
cord-350836-1enteev7	346	1	It	-PRON-	PRP
cord-350836-1enteev7	346	2	is	be	VBZ
cord-350836-1enteev7	346	3	important	important	JJ
cord-350836-1enteev7	346	4	to	to	TO
cord-350836-1enteev7	346	5	consider	consider	VB
cord-350836-1enteev7	346	6	the	the	DT
cord-350836-1enteev7	346	7	different	different	JJ
cord-350836-1enteev7	346	8	regulatory	regulatory	JJ
cord-350836-1enteev7	346	9	mechanisms	mechanism	NNS
cord-350836-1enteev7	346	10	of	of	IN
cord-350836-1enteev7	346	11	RIG	rig	NN
cord-350836-1enteev7	346	12	-	-	:
cord-350836-1enteev7	346	13	I	I	NNP
cord-350836-1enteev7	346	14	and	and	CC
cord-350836-1enteev7	346	15	MDA5	MDA5	NNP
cord-350836-1enteev7	346	16	when	when	WRB
cord-350836-1enteev7	346	17	considering	consider	VBG
cord-350836-1enteev7	346	18	their	-PRON-	PRP$
cord-350836-1enteev7	346	19	different	different	JJ
cord-350836-1enteev7	346	20	functionalities	functionality	NNS
cord-350836-1enteev7	346	21	(	(	-LRB-
cord-350836-1enteev7	346	22	Figures	figure	NNS
cord-350836-1enteev7	346	23	4	4	CD
cord-350836-1enteev7	346	24	,	,	,
cord-350836-1enteev7	346	25	6	6	CD
cord-350836-1enteev7	346	26	)	)	-RRB-
cord-350836-1enteev7	346	27	.	.	.
cord-350836-1enteev7	347	1	One	one	CD
cord-350836-1enteev7	347	2	of	of	IN
cord-350836-1enteev7	347	3	the	the	DT
cord-350836-1enteev7	347	4	key	key	JJ
cord-350836-1enteev7	347	5	differences	difference	NNS
cord-350836-1enteev7	347	6	between	between	IN
cord-350836-1enteev7	347	7	these	these	DT
cord-350836-1enteev7	347	8	proteins	protein	NNS
cord-350836-1enteev7	347	9	is	be	VBZ
cord-350836-1enteev7	347	10	in	in	IN
cord-350836-1enteev7	347	11	their	-PRON-	PRP$
cord-350836-1enteev7	347	12	post	post	JJ
cord-350836-1enteev7	347	13	-	-	JJ
cord-350836-1enteev7	347	14	translation	translation	JJ
cord-350836-1enteev7	347	15	modifications	modification	NNS
cord-350836-1enteev7	347	16	(	(	-LRB-
cord-350836-1enteev7	347	17	96	96	CD
cord-350836-1enteev7	347	18	)	)	-RRB-
cord-350836-1enteev7	347	19	.	.	.
cord-350836-1enteev7	348	1	Ubiquitination	Ubiquitination	NNP
cord-350836-1enteev7	348	2	of	of	IN
cord-350836-1enteev7	348	3	RIG-	RIG-	NNP
cord-350836-1enteev7	349	1	I	-PRON-	PRP
cord-350836-1enteev7	349	2	is	be	VBZ
cord-350836-1enteev7	349	3	necessary	necessary	JJ
cord-350836-1enteev7	349	4	for	for	IN
cord-350836-1enteev7	349	5	its	-PRON-	PRP$
cord-350836-1enteev7	349	6	activation	activation	NN
cord-350836-1enteev7	349	7	(	(	-LRB-
cord-350836-1enteev7	349	8	118	118	CD
cord-350836-1enteev7	349	9	)	)	-RRB-
cord-350836-1enteev7	349	10	and	and	CC
cord-350836-1enteev7	349	11	is	be	VBZ
cord-350836-1enteev7	349	12	a	a	DT
cord-350836-1enteev7	349	13	point	point	NN
cord-350836-1enteev7	349	14	of	of	IN
cord-350836-1enteev7	349	15	negative	negative	JJ
cord-350836-1enteev7	349	16	regulation	regulation	NN
cord-350836-1enteev7	349	17	by	by	IN
cord-350836-1enteev7	349	18	host	host	NN
cord-350836-1enteev7	349	19	proteins	protein	NNS
cord-350836-1enteev7	349	20	(	(	-LRB-
cord-350836-1enteev7	349	21	117	117	CD
cord-350836-1enteev7	349	22	,	,	,
cord-350836-1enteev7	349	23	284	284	CD
cord-350836-1enteev7	349	24	,	,	,
cord-350836-1enteev7	349	25	285	285	CD
cord-350836-1enteev7	349	26	)	)	-RRB-
cord-350836-1enteev7	349	27	,	,	,
cord-350836-1enteev7	349	28	viral	viral	JJ
cord-350836-1enteev7	349	29	proteins	protein	NNS
cord-350836-1enteev7	349	30	(	(	-LRB-
cord-350836-1enteev7	349	31	281	281	CD
cord-350836-1enteev7	349	32	,	,	,
cord-350836-1enteev7	349	33	286	286	CD
cord-350836-1enteev7	349	34	,	,	,
cord-350836-1enteev7	349	35	287	287	CD
cord-350836-1enteev7	349	36	)	)	-RRB-
cord-350836-1enteev7	349	37	and	and	CC
cord-350836-1enteev7	349	38	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	349	39	mimics	mimic	NNS
cord-350836-1enteev7	349	40	(	(	-LRB-
cord-350836-1enteev7	349	41	288	288	CD
cord-350836-1enteev7	349	42	)	)	-RRB-
cord-350836-1enteev7	349	43	as	as	RB
cord-350836-1enteev7	349	44	well	well	RB
cord-350836-1enteev7	349	45	as	as	IN
cord-350836-1enteev7	349	46	positively	positively	RB
cord-350836-1enteev7	349	47	regulated	regulate	VBN
cord-350836-1enteev7	349	48	by	by	IN
cord-350836-1enteev7	349	49	influenza	influenza	NN
cord-350836-1enteev7	349	50	B	b	NN
cord-350836-1enteev7	349	51	NS1	ns1	NN
cord-350836-1enteev7	349	52	protein	protein	NN
cord-350836-1enteev7	349	53	(	(	-LRB-
cord-350836-1enteev7	349	54	289	289	CD
cord-350836-1enteev7	349	55	)	)	-RRB-
cord-350836-1enteev7	349	56	and	and	CC
cord-350836-1enteev7	349	57	another	another	DT
cord-350836-1enteev7	349	58	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	349	59	mimic	mimic	NN
cord-350836-1enteev7	349	60	(	(	-LRB-
cord-350836-1enteev7	349	61	290	290	CD
cord-350836-1enteev7	349	62	)	)	-RRB-
cord-350836-1enteev7	349	63	.	.	.
cord-350836-1enteev7	350	1	On	on	IN
cord-350836-1enteev7	350	2	the	the	DT
cord-350836-1enteev7	350	3	contrary	contrary	NN
cord-350836-1enteev7	350	4	,	,	,
cord-350836-1enteev7	350	5	MDA5	MDA5	NNP
cord-350836-1enteev7	350	6	is	be	VBZ
cord-350836-1enteev7	350	7	more	more	RBR
cord-350836-1enteev7	350	8	well	well	RB
cord-350836-1enteev7	350	9	-	-	HYPH
cord-350836-1enteev7	350	10	known	know	VBN
cord-350836-1enteev7	350	11	to	to	TO
cord-350836-1enteev7	350	12	be	be	VB
cord-350836-1enteev7	350	13	negatively	negatively	RB
cord-350836-1enteev7	350	14	regulated	regulate	VBN
cord-350836-1enteev7	350	15	by	by	IN
cord-350836-1enteev7	350	16	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	350	17	(	(	-LRB-
cord-350836-1enteev7	350	18	291	291	CD
cord-350836-1enteev7	350	19	)	)	-RRB-
cord-350836-1enteev7	350	20	,	,	,
cord-350836-1enteev7	350	21	with	with	IN
cord-350836-1enteev7	350	22	positive	positive	JJ
cord-350836-1enteev7	350	23	regulation	regulation	NN
cord-350836-1enteev7	350	24	by	by	IN
cord-350836-1enteev7	350	25	K63	K63	NNP
cord-350836-1enteev7	350	26	ubiquitination	ubiquitination	IN
cord-350836-1enteev7	350	27	being	be	VBG
cord-350836-1enteev7	350	28	more	more	RBR
cord-350836-1enteev7	350	29	controversial	controversial	JJ
cord-350836-1enteev7	350	30	.	.	.
cord-350836-1enteev7	351	1	While	while	IN
cord-350836-1enteev7	351	2	the	the	DT
cord-350836-1enteev7	351	3	deubiquitinase	deubiquitinase	NN
cord-350836-1enteev7	351	4	USP3	USP3	NNP
cord-350836-1enteev7	351	5	inhibits	inhibit	VBZ
cord-350836-1enteev7	351	6	MDA5	MDA5	NNP
cord-350836-1enteev7	351	7	as	as	RB
cord-350836-1enteev7	351	8	well	well	RB
cord-350836-1enteev7	351	9	as	as	IN
cord-350836-1enteev7	351	10	RIG	rig	NN
cord-350836-1enteev7	351	11	-	-	:
cord-350836-1enteev7	351	12	I	-PRON-	PRP
cord-350836-1enteev7	351	13	,	,	,
cord-350836-1enteev7	351	14	it	-PRON-	PRP
cord-350836-1enteev7	351	15	is	be	VBZ
cord-350836-1enteev7	351	16	thought	think	VBN
cord-350836-1enteev7	351	17	that	that	IN
cord-350836-1enteev7	351	18	this	this	DT
cord-350836-1enteev7	351	19	may	may	MD
cord-350836-1enteev7	351	20	be	be	VB
cord-350836-1enteev7	351	21	due	due	JJ
cord-350836-1enteev7	351	22	to	to	IN
cord-350836-1enteev7	351	23	USP3	USP3	NNP
cord-350836-1enteev7	351	24	directly	directly	RB
cord-350836-1enteev7	351	25	binding	bind	VBG
cord-350836-1enteev7	351	26	the	the	DT
cord-350836-1enteev7	351	27	MDA5	MDA5	NNP
cord-350836-1enteev7	351	28	CARD	card	NN
cord-350836-1enteev7	351	29	domain	domain	NN
cord-350836-1enteev7	351	30	to	to	TO
cord-350836-1enteev7	351	31	prevent	prevent	VB
cord-350836-1enteev7	351	32	RNA	RNA	NNP
cord-350836-1enteev7	351	33	filamentation	filamentation	NN
cord-350836-1enteev7	351	34	(	(	-LRB-
cord-350836-1enteev7	351	35	284	284	CD
cord-350836-1enteev7	351	36	)	)	-RRB-
cord-350836-1enteev7	351	37	.	.	.
cord-350836-1enteev7	352	1	This	this	DT
cord-350836-1enteev7	352	2	raises	raise	VBZ
cord-350836-1enteev7	352	3	the	the	DT
cord-350836-1enteev7	352	4	question	question	NN
cord-350836-1enteev7	352	5	of	of	IN
cord-350836-1enteev7	352	6	how	how	WRB
cord-350836-1enteev7	352	7	RIG	rig	NN
cord-350836-1enteev7	352	8	-	-	:
cord-350836-1enteev7	352	9	I	-PRON-	PRP
cord-350836-1enteev7	352	10	can	can	MD
cord-350836-1enteev7	352	11	maintain	maintain	VB
cord-350836-1enteev7	352	12	its	-PRON-	PRP$
cord-350836-1enteev7	352	13	stability	stability	NN
cord-350836-1enteev7	352	14	outside	outside	IN
cord-350836-1enteev7	352	15	of	of	IN
cord-350836-1enteev7	352	16	the	the	DT
cord-350836-1enteev7	352	17	proteasome	proteasome	NN
cord-350836-1enteev7	352	18	,	,	,
cord-350836-1enteev7	352	19	as	as	IN
cord-350836-1enteev7	352	20	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	352	21	at	at	IN
cord-350836-1enteev7	352	22	other	other	JJ
cord-350836-1enteev7	352	23	lysine	lysine	NN
cord-350836-1enteev7	352	24	residues	residue	NNS
cord-350836-1enteev7	352	25	in	in	IN
cord-350836-1enteev7	352	26	RIG	rig	NN
cord-350836-1enteev7	352	27	-	-	:
cord-350836-1enteev7	352	28	I	-PRON-	PRP
cord-350836-1enteev7	352	29	besides	besides	IN
cord-350836-1enteev7	352	30	K172	K172	NNP
cord-350836-1enteev7	352	31	induces	induce	VBZ
cord-350836-1enteev7	352	32	proteasomal	proteasomal	JJ
cord-350836-1enteev7	352	33	degradation	degradation	NN
cord-350836-1enteev7	352	34	(	(	-LRB-
cord-350836-1enteev7	352	35	291	291	CD
cord-350836-1enteev7	352	36	)	)	-RRB-
cord-350836-1enteev7	352	37	(	(	-LRB-
cord-350836-1enteev7	352	38	292	292	CD
cord-350836-1enteev7	352	39	)	)	-RRB-
cord-350836-1enteev7	352	40	(	(	-LRB-
cord-350836-1enteev7	352	41	293	293	CD
cord-350836-1enteev7	352	42	)	)	-RRB-
cord-350836-1enteev7	352	43	.	.	.
cord-350836-1enteev7	353	1	This	this	DT
cord-350836-1enteev7	353	2	proteasomal	proteasomal	JJ
cord-350836-1enteev7	353	3	degradation	degradation	NN
cord-350836-1enteev7	353	4	may	may	MD
cord-350836-1enteev7	353	5	be	be	VB
cord-350836-1enteev7	353	6	mediated	mediate	VBN
cord-350836-1enteev7	353	7	by	by	IN
cord-350836-1enteev7	353	8	a	a	DT
cord-350836-1enteev7	353	9	p62	p62	NN
cord-350836-1enteev7	353	10	autophagic	autophagic	NN
cord-350836-1enteev7	353	11	complex	complex	NN
cord-350836-1enteev7	353	12	that	that	IN
cord-350836-1enteev7	353	13	associates	associate	NNS
cord-350836-1enteev7	353	14	with	with	IN
cord-350836-1enteev7	353	15	LRRC25	lrrc25	NN
cord-350836-1enteev7	353	16	/	/	SYM
cord-350836-1enteev7	353	17	ISG15	isg15	NN
cord-350836-1enteev7	353	18	(	(	-LRB-
cord-350836-1enteev7	353	19	294	294	CD
cord-350836-1enteev7	353	20	)	)	-RRB-
cord-350836-1enteev7	353	21	and	and	CC
cord-350836-1enteev7	353	22	SQSTM1	SQSTM1	NNP
cord-350836-1enteev7	353	23	(	(	-LRB-
cord-350836-1enteev7	353	24	295	295	CD
cord-350836-1enteev7	353	25	)	)	-RRB-
cord-350836-1enteev7	353	26	and	and	CC
cord-350836-1enteev7	353	27	also	also	RB
cord-350836-1enteev7	353	28	mediates	mediate	VBZ
cord-350836-1enteev7	353	29	mitophagy	mitophagy	NN
cord-350836-1enteev7	353	30	and	and	CC
cord-350836-1enteev7	353	31	downregulation	downregulation	NN
cord-350836-1enteev7	353	32	of	of	IN
cord-350836-1enteev7	353	33	MAVS	MAVS	NNPS
cord-350836-1enteev7	353	34	signaling	signal	VBG
cord-350836-1enteev7	353	35	during	during	IN
cord-350836-1enteev7	353	36	measles	measle	NNS
cord-350836-1enteev7	353	37	virus	virus	NN
cord-350836-1enteev7	353	38	infection	infection	NN
cord-350836-1enteev7	353	39	(	(	-LRB-
cord-350836-1enteev7	353	40	296	296	CD
cord-350836-1enteev7	353	41	)	)	-RRB-
cord-350836-1enteev7	353	42	.	.	.
cord-350836-1enteev7	354	1	One	one	CD
cord-350836-1enteev7	354	2	key	key	JJ
cord-350836-1enteev7	354	3	observation	observation	NN
cord-350836-1enteev7	354	4	is	be	VBZ
cord-350836-1enteev7	354	5	that	that	IN
cord-350836-1enteev7	354	6	,	,	,
cord-350836-1enteev7	354	7	while	while	IN
cord-350836-1enteev7	354	8	both	both	DT
cord-350836-1enteev7	354	9	RIG	rig	NN
cord-350836-1enteev7	354	10	-	-	:
cord-350836-1enteev7	354	11	I	I	NNP
cord-350836-1enteev7	354	12	and	and	CC
cord-350836-1enteev7	354	13	MDA5	MDA5	NNP
cord-350836-1enteev7	354	14	are	be	VBP
cord-350836-1enteev7	354	15	cleaved	cleave	VBN
cord-350836-1enteev7	354	16	during	during	IN
cord-350836-1enteev7	354	17	picornavirus	picornavirus	NNP
cord-350836-1enteev7	354	18	infection	infection	NN
cord-350836-1enteev7	354	19	,	,	,
cord-350836-1enteev7	354	20	this	this	DT
cord-350836-1enteev7	354	21	cleavage	cleavage	NN
cord-350836-1enteev7	354	22	is	be	VBZ
cord-350836-1enteev7	354	23	mediated	mediate	VBN
cord-350836-1enteev7	354	24	by	by	IN
cord-350836-1enteev7	354	25	the	the	DT
cord-350836-1enteev7	354	26	viral	viral	JJ
cord-350836-1enteev7	354	27	proteinase	proteinase	NN
cord-350836-1enteev7	354	28	3C	3c	NN
cord-350836-1enteev7	354	29	pro	pro	NNP
cord-350836-1enteev7	354	30	(	(	-LRB-
cord-350836-1enteev7	354	31	297	297	CD
cord-350836-1enteev7	354	32	)	)	-RRB-
cord-350836-1enteev7	354	33	and	and	CC
cord-350836-1enteev7	354	34	is	be	VBZ
cord-350836-1enteev7	354	35	independent	independent	JJ
cord-350836-1enteev7	354	36	of	of	IN
cord-350836-1enteev7	354	37	the	the	DT
cord-350836-1enteev7	354	38	proteasome	proteasome	NN
cord-350836-1enteev7	354	39	(	(	-LRB-
cord-350836-1enteev7	354	40	298	298	CD
cord-350836-1enteev7	354	41	)	)	-RRB-
cord-350836-1enteev7	354	42	for	for	IN
cord-350836-1enteev7	354	43	RIG	rig	NN
cord-350836-1enteev7	354	44	-	-	:
cord-350836-1enteev7	354	45	I	-PRON-	PRP
cord-350836-1enteev7	354	46	,	,	,
cord-350836-1enteev7	354	47	whereas	whereas	IN
cord-350836-1enteev7	354	48	it	-PRON-	PRP
cord-350836-1enteev7	354	49	is	be	VBZ
cord-350836-1enteev7	354	50	mediated	mediate	VBN
cord-350836-1enteev7	354	51	by	by	IN
cord-350836-1enteev7	354	52	cellular	cellular	JJ
cord-350836-1enteev7	354	53	caspases	caspase	NNS
cord-350836-1enteev7	354	54	and	and	CC
cord-350836-1enteev7	354	55	the	the	DT
cord-350836-1enteev7	354	56	proteasome	proteasome	NN
cord-350836-1enteev7	354	57	for	for	IN
cord-350836-1enteev7	354	58	MDA5	MDA5	NNP
cord-350836-1enteev7	354	59	(	(	-LRB-
cord-350836-1enteev7	354	60	299	299	CD
cord-350836-1enteev7	354	61	)	)	-RRB-
cord-350836-1enteev7	354	62	.	.	.
cord-350836-1enteev7	355	1	MDA5	MDA5	NNP
cord-350836-1enteev7	355	2	is	be	VBZ
cord-350836-1enteev7	355	3	also	also	RB
cord-350836-1enteev7	355	4	cleaved	cleave	VBN
cord-350836-1enteev7	355	5	by	by	IN
cord-350836-1enteev7	355	6	caspases	caspase	NNS
cord-350836-1enteev7	355	7	during	during	IN
cord-350836-1enteev7	355	8	apoptosis	apoptosis	NN
cord-350836-1enteev7	355	9	(	(	-LRB-
cord-350836-1enteev7	355	10	4	4	CD
cord-350836-1enteev7	355	11	)	)	-RRB-
cord-350836-1enteev7	355	12	,	,	,
cord-350836-1enteev7	355	13	though	though	IN
cord-350836-1enteev7	355	14	it	-PRON-	PRP
cord-350836-1enteev7	355	15	has	have	VBZ
cord-350836-1enteev7	355	16	n't	not	RB
cord-350836-1enteev7	355	17	been	be	VBN
cord-350836-1enteev7	355	18	shown	show	VBN
cord-350836-1enteev7	355	19	whether	whether	IN
cord-350836-1enteev7	355	20	this	this	DT
cord-350836-1enteev7	355	21	is	be	VBZ
cord-350836-1enteev7	355	22	mediated	mediate	VBN
cord-350836-1enteev7	355	23	by	by	IN
cord-350836-1enteev7	355	24	MDA5	MDA5	NNP
cord-350836-1enteev7	355	25	's	's	POS
cord-350836-1enteev7	355	26	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	355	27	sites	site	NNS
cord-350836-1enteev7	355	28	.	.	.
cord-350836-1enteev7	356	1	The	the	DT
cord-350836-1enteev7	356	2	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	356	3	linkage	linkage	NN
cord-350836-1enteev7	356	4	site	site	NN
cord-350836-1enteev7	356	5	may	may	MD
cord-350836-1enteev7	356	6	be	be	VB
cord-350836-1enteev7	356	7	a	a	DT
cord-350836-1enteev7	356	8	determinate	determinate	NN
cord-350836-1enteev7	356	9	of	of	IN
cord-350836-1enteev7	356	10	function	function	NN
cord-350836-1enteev7	356	11	,	,	,
cord-350836-1enteev7	356	12	as	as	IN
cord-350836-1enteev7	356	13	the	the	DT
cord-350836-1enteev7	356	14	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	356	15	ligases	ligase	NNS
cord-350836-1enteev7	356	16	RNF122	RNF122	NNP
cord-350836-1enteev7	356	17	(	(	-LRB-
cord-350836-1enteev7	356	18	300	300	CD
cord-350836-1enteev7	356	19	)	)	-RRB-
cord-350836-1enteev7	356	20	and	and	CC
cord-350836-1enteev7	356	21	STUB1	STUB1	NNS
cord-350836-1enteev7	356	22	(	(	-LRB-
cord-350836-1enteev7	356	23	293	293	CD
cord-350836-1enteev7	356	24	,	,	,
cord-350836-1enteev7	356	25	301	301	CD
cord-350836-1enteev7	356	26	)	)	-RRB-
cord-350836-1enteev7	356	27	have	have	VBP
cord-350836-1enteev7	356	28	been	be	VBN
cord-350836-1enteev7	356	29	shown	show	VBN
cord-350836-1enteev7	356	30	to	to	TO
cord-350836-1enteev7	356	31	negatively	negatively	RB
cord-350836-1enteev7	356	32	regulate	regulate	VB
cord-350836-1enteev7	356	33	RIG	rig	NN
cord-350836-1enteev7	357	1	-I	-i	WDT
cord-350836-1enteev7	357	2	catalyzed	catalyze	VBD
cord-350836-1enteev7	357	3	K48linked	K48linked	NNP
cord-350836-1enteev7	357	4	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	357	5	as	as	IN
cord-350836-1enteev7	357	6	opposed	oppose	VBN
cord-350836-1enteev7	357	7	to	to	IN
cord-350836-1enteev7	357	8	the	the	DT
cord-350836-1enteev7	357	9	known	know	VBN
cord-350836-1enteev7	357	10	K63-linked	K63-linked	NNP
cord-350836-1enteev7	357	11	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	357	12	at	at	IN
cord-350836-1enteev7	357	13	the	the	DT
cord-350836-1enteev7	357	14	K172	K172	NNP
cord-350836-1enteev7	357	15	,	,	.
cord-350836-1enteev7	358	1	K849	k849	VB
cord-350836-1enteev7	358	2	and	and	CC
cord-350836-1enteev7	358	3	K851	K851	NNP
cord-350836-1enteev7	358	4	activating	activate	VBG
cord-350836-1enteev7	358	5	sites	site	NNS
cord-350836-1enteev7	358	6	,	,	,
cord-350836-1enteev7	358	7	and	and	CC
cord-350836-1enteev7	358	8	RNF125	RNF125	NNP
cord-350836-1enteev7	358	9	has	have	VBZ
cord-350836-1enteev7	358	10	also	also	RB
cord-350836-1enteev7	358	11	been	be	VBN
cord-350836-1enteev7	358	12	proposed	propose	VBN
cord-350836-1enteev7	358	13	to	to	IN
cord-350836-1enteev7	358	14	K48	K48	NNP
cord-350836-1enteev7	358	15	ubiquitinate	ubiquitinate	JJ
cord-350836-1enteev7	358	16	RIG	rig	NN
cord-350836-1enteev7	358	17	-	-	:
cord-350836-1enteev7	358	18	I	I	NNP
cord-350836-1enteev7	358	19	(	(	-LRB-
cord-350836-1enteev7	358	20	291	291	CD
cord-350836-1enteev7	358	21	)	)	-RRB-
cord-350836-1enteev7	359	1	(	(	-LRB-
cord-350836-1enteev7	359	2	though	though	IN
cord-350836-1enteev7	359	3	it	-PRON-	PRP
cord-350836-1enteev7	359	4	has	have	VBZ
cord-350836-1enteev7	359	5	n't	not	RB
cord-350836-1enteev7	359	6	been	be	VBN
cord-350836-1enteev7	359	7	shown	show	VBN
cord-350836-1enteev7	359	8	directly	directly	RB
cord-350836-1enteev7	359	9	)	)	-RRB-
cord-350836-1enteev7	360	1	(	(	-LRB-
cord-350836-1enteev7	360	2	59	59	CD
cord-350836-1enteev7	360	3	)	)	-RRB-
cord-350836-1enteev7	360	4	.	.	.
cord-350836-1enteev7	361	1	TRIM40	TRIM40	NNP
cord-350836-1enteev7	361	2	has	have	VBZ
cord-350836-1enteev7	361	3	also	also	RB
cord-350836-1enteev7	361	4	been	be	VBN
cord-350836-1enteev7	361	5	shown	show	VBN
cord-350836-1enteev7	361	6	to	to	TO
cord-350836-1enteev7	361	7	negatively	negatively	RB
cord-350836-1enteev7	361	8	regulate	regulate	VB
cord-350836-1enteev7	361	9	RIG	rig	NN
cord-350836-1enteev7	361	10	-	-	:
cord-350836-1enteev7	361	11	I	I	NNP
cord-350836-1enteev7	361	12	and	and	CC
cord-350836-1enteev7	361	13	MDA5	MDA5	NNP
cord-350836-1enteev7	361	14	by	by	IN
cord-350836-1enteev7	361	15	K27	K27	NNP
cord-350836-1enteev7	361	16	and	and	CC
cord-350836-1enteev7	361	17	K48	K48	NNP
cord-350836-1enteev7	361	18	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	361	19	(	(	-LRB-
cord-350836-1enteev7	361	20	123	123	CD
cord-350836-1enteev7	361	21	)	)	-RRB-
cord-350836-1enteev7	361	22	.	.	.
cord-350836-1enteev7	362	1	Substantiating	substantiate	VBG
cord-350836-1enteev7	362	2	the	the	DT
cord-350836-1enteev7	362	3	possibility	possibility	NN
cord-350836-1enteev7	362	4	that	that	IN
cord-350836-1enteev7	362	5	K63	K63	NNPS
cord-350836-1enteev7	362	6	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	362	7	on	on	IN
cord-350836-1enteev7	362	8	RIG	rig	NN
cord-350836-1enteev7	362	9	-	-	:
cord-350836-1enteev7	362	10	I	-PRON-	PRP
cord-350836-1enteev7	362	11	may	may	MD
cord-350836-1enteev7	362	12	be	be	VB
cord-350836-1enteev7	362	13	functionally	functionally	RB
cord-350836-1enteev7	362	14	distinct	distinct	JJ
cord-350836-1enteev7	362	15	from	from	IN
cord-350836-1enteev7	362	16	its	-PRON-	PRP$
cord-350836-1enteev7	362	17	other	other	JJ
cord-350836-1enteev7	362	18	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	362	19	sites	site	NNS
cord-350836-1enteev7	362	20	by	by	IN
cord-350836-1enteev7	362	21	protecting	protect	VBG
cord-350836-1enteev7	362	22	it	-PRON-	PRP
cord-350836-1enteev7	362	23	from	from	IN
cord-350836-1enteev7	362	24	degradation	degradation	NN
cord-350836-1enteev7	362	25	is	be	VBZ
cord-350836-1enteev7	362	26	the	the	DT
cord-350836-1enteev7	362	27	finding	finding	NN
cord-350836-1enteev7	362	28	that	that	IN
cord-350836-1enteev7	362	29	the	the	DT
cord-350836-1enteev7	362	30	NS1	ns1	NN
cord-350836-1enteev7	362	31	protein	protein	NN
cord-350836-1enteev7	362	32	of	of	IN
cord-350836-1enteev7	362	33	West	West	NNP
cord-350836-1enteev7	362	34	Nile	Nile	NNP
cord-350836-1enteev7	362	35	virus	virus	NN
cord-350836-1enteev7	362	36	(	(	-LRB-
cord-350836-1enteev7	362	37	WNV	WNV	NNP
cord-350836-1enteev7	362	38	)	)	-RRB-
cord-350836-1enteev7	362	39	targets	target	VBZ
cord-350836-1enteev7	362	40	both	both	CC
cord-350836-1enteev7	362	41	RIG	rig	NN
cord-350836-1enteev7	362	42	-	-	:
cord-350836-1enteev7	362	43	I	I	NNP
cord-350836-1enteev7	362	44	and	and	CC
cord-350836-1enteev7	362	45	MDA5	MDA5	NNP
cord-350836-1enteev7	362	46	for	for	IN
cord-350836-1enteev7	362	47	degradation	degradation	NN
cord-350836-1enteev7	362	48	by	by	IN
cord-350836-1enteev7	362	49	proteasomes	proteasomes	NNP
cord-350836-1enteev7	362	50	.	.	.
cord-350836-1enteev7	363	1	Additionally	additionally	RB
cord-350836-1enteev7	363	2	,	,	,
cord-350836-1enteev7	363	3	NS1	ns1	LS
cord-350836-1enteev7	363	4	inhibited	inhibit	VBD
cord-350836-1enteev7	363	5	K63	K63	NNP
cord-350836-1enteev7	363	6	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	363	7	of	of	IN
cord-350836-1enteev7	363	8	RIG	rig	NN
cord-350836-1enteev7	363	9	-	-	:
cord-350836-1enteev7	363	10	I	-PRON-	PRP
cord-350836-1enteev7	363	11	,	,	,
cord-350836-1enteev7	363	12	but	but	CC
cord-350836-1enteev7	364	1	MDA5	MDA5	NNP
cord-350836-1enteev7	364	2	was	be	VBD
cord-350836-1enteev7	364	3	not	not	RB
cord-350836-1enteev7	364	4	found	find	VBN
cord-350836-1enteev7	364	5	to	to	TO
cord-350836-1enteev7	364	6	be	be	VB
cord-350836-1enteev7	364	7	K63	K63	NNP
cord-350836-1enteev7	364	8	ubiquitinated	ubiquitinate	VBN
cord-350836-1enteev7	364	9	(	(	-LRB-
cord-350836-1enteev7	364	10	126	126	CD
cord-350836-1enteev7	364	11	)	)	-RRB-
cord-350836-1enteev7	364	12	.	.	.
cord-350836-1enteev7	365	1	Heat	heat	NN
cord-350836-1enteev7	365	2	shock	shock	NN
cord-350836-1enteev7	365	3	protein	protein	NN
cord-350836-1enteev7	365	4	90-alpha	90-alpha	CD
cord-350836-1enteev7	365	5	(	(	-LRB-
cord-350836-1enteev7	365	6	HSP90	HSP90	NNP
cord-350836-1enteev7	365	7	)	)	-RRB-
cord-350836-1enteev7	365	8	has	have	VBZ
cord-350836-1enteev7	365	9	been	be	VBN
cord-350836-1enteev7	365	10	found	find	VBN
cord-350836-1enteev7	365	11	to	to	TO
cord-350836-1enteev7	365	12	protect	protect	VB
cord-350836-1enteev7	365	13	RIG	rig	NN
cord-350836-1enteev7	365	14	-	-	:
cord-350836-1enteev7	365	15	I	i	NN
cord-350836-1enteev7	365	16	from	from	IN
cord-350836-1enteev7	365	17	proteasomal	proteasomal	JJ
cord-350836-1enteev7	365	18	degradation	degradation	NN
cord-350836-1enteev7	365	19	,	,	,
cord-350836-1enteev7	365	20	but	but	CC
cord-350836-1enteev7	365	21	it	-PRON-	PRP
cord-350836-1enteev7	365	22	is	be	VBZ
cord-350836-1enteev7	365	23	unknown	unknown	JJ
cord-350836-1enteev7	365	24	which	which	WDT
cord-350836-1enteev7	365	25	type	type	NN
cord-350836-1enteev7	365	26	of	of	IN
cord-350836-1enteev7	365	27	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	365	28	that	that	WDT
cord-350836-1enteev7	365	29	is	be	VBZ
cord-350836-1enteev7	365	30	inhibited	inhibit	VBN
cord-350836-1enteev7	365	31	by	by	IN
cord-350836-1enteev7	365	32	HSP90	HSP90	NNP
cord-350836-1enteev7	365	33	(	(	-LRB-
cord-350836-1enteev7	365	34	302	302	CD
cord-350836-1enteev7	365	35	)	)	-RRB-
cord-350836-1enteev7	365	36	.	.	.
cord-350836-1enteev7	366	1	Taken	take	VBN
cord-350836-1enteev7	366	2	together	together	RB
cord-350836-1enteev7	366	3	,	,	,
cord-350836-1enteev7	366	4	the	the	DT
cord-350836-1enteev7	366	5	experimental	experimental	JJ
cord-350836-1enteev7	366	6	evidence	evidence	NN
cord-350836-1enteev7	366	7	suggests	suggest	VBZ
cord-350836-1enteev7	366	8	that	that	IN
cord-350836-1enteev7	366	9	RIG	rig	NN
cord-350836-1enteev7	366	10	-	-	:
cord-350836-1enteev7	366	11	I	-PRON-	PRP
cord-350836-1enteev7	366	12	may	may	MD
cord-350836-1enteev7	366	13	be	be	VB
cord-350836-1enteev7	366	14	protected	protect	VBN
cord-350836-1enteev7	366	15	from	from	IN
cord-350836-1enteev7	366	16	proteasome	proteasome	JJ
cord-350836-1enteev7	366	17	degradation	degradation	NN
cord-350836-1enteev7	366	18	despite	despite	IN
cord-350836-1enteev7	366	19	its	-PRON-	PRP$
cord-350836-1enteev7	366	20	activating	activate	VBG
cord-350836-1enteev7	366	21	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	366	22	moieties	moiety	NNS
cord-350836-1enteev7	366	23	(	(	-LRB-
cord-350836-1enteev7	366	24	52	52	CD
cord-350836-1enteev7	366	25	)	)	-RRB-
cord-350836-1enteev7	366	26	.	.	.
cord-350836-1enteev7	367	1	This	this	DT
cord-350836-1enteev7	367	2	warrants	warrant	VBZ
cord-350836-1enteev7	367	3	further	further	JJ
cord-350836-1enteev7	367	4	studies	study	NNS
cord-350836-1enteev7	367	5	for	for	IN
cord-350836-1enteev7	367	6	mechanistic	mechanistic	JJ
cord-350836-1enteev7	367	7	elucidation	elucidation	NN
cord-350836-1enteev7	367	8	.	.	.
cord-350836-1enteev7	368	1	RIG	rig	NN
cord-350836-1enteev7	368	2	-	-	:
cord-350836-1enteev7	368	3	I	I	NNP
cord-350836-1enteev7	368	4	and	and	CC
cord-350836-1enteev7	368	5	MDA5	MDA5	NNP
cord-350836-1enteev7	368	6	additionally	additionally	RB
cord-350836-1enteev7	368	7	interact	interact	VBP
cord-350836-1enteev7	368	8	with	with	IN
cord-350836-1enteev7	368	9	different	different	JJ
cord-350836-1enteev7	368	10	cellular	cellular	JJ
cord-350836-1enteev7	368	11	co	co	NNS
cord-350836-1enteev7	368	12	-	-	NNS
cord-350836-1enteev7	368	13	factors	factor	NNS
cord-350836-1enteev7	368	14	,	,	,
cord-350836-1enteev7	368	15	contributing	contribute	VBG
cord-350836-1enteev7	368	16	to	to	IN
cord-350836-1enteev7	368	17	their	-PRON-	PRP$
cord-350836-1enteev7	368	18	differential	differential	JJ
cord-350836-1enteev7	368	19	regulations	regulation	NNS
cord-350836-1enteev7	368	20	of	of	IN
cord-350836-1enteev7	368	21	function	function	NN
cord-350836-1enteev7	368	22	.	.	.
cord-350836-1enteev7	369	1	RIG	rig	NN
cord-350836-1enteev7	369	2	-	-	:
cord-350836-1enteev7	369	3	I	-PRON-	PRP
cord-350836-1enteev7	369	4	is	be	VBZ
cord-350836-1enteev7	369	5	well	well	RB
cord-350836-1enteev7	369	6	-	-	HYPH
cord-350836-1enteev7	369	7	known	know	VBN
cord-350836-1enteev7	369	8	for	for	IN
cord-350836-1enteev7	369	9	being	be	VBG
cord-350836-1enteev7	369	10	potentiated	potentiate	VBN
cord-350836-1enteev7	369	11	by	by	IN
cord-350836-1enteev7	369	12	proteins	protein	NNS
cord-350836-1enteev7	369	13	that	that	WDT
cord-350836-1enteev7	369	14	also	also	RB
cord-350836-1enteev7	369	15	bind	bind	VBP
cord-350836-1enteev7	369	16	dsRNA	dsrna	NN
cord-350836-1enteev7	369	17	,	,	,
cord-350836-1enteev7	369	18	such	such	JJ
cord-350836-1enteev7	369	19	as	as	IN
cord-350836-1enteev7	369	20	(	(	-LRB-
cord-350836-1enteev7	369	21	PACT	pact	NN
cord-350836-1enteev7	369	22	)	)	-RRB-
cord-350836-1enteev7	369	23	(	(	-LRB-
cord-350836-1enteev7	369	24	303	303	CD
cord-350836-1enteev7	369	25	,	,	,
cord-350836-1enteev7	369	26	304	304	CD
cord-350836-1enteev7	369	27	)	)	-RRB-
cord-350836-1enteev7	369	28	,	,	,
cord-350836-1enteev7	369	29	which	which	WDT
cord-350836-1enteev7	369	30	was	be	VBD
cord-350836-1enteev7	369	31	first	first	RB
cord-350836-1enteev7	369	32	discovered	discover	VBN
cord-350836-1enteev7	369	33	as	as	IN
cord-350836-1enteev7	369	34	a	a	DT
cord-350836-1enteev7	369	35	protein	protein	NN
cord-350836-1enteev7	369	36	activator	activator	NN
cord-350836-1enteev7	369	37	of	of	IN
cord-350836-1enteev7	369	38	PKR	PKR	NNP
cord-350836-1enteev7	369	39	,	,	,
cord-350836-1enteev7	369	40	the	the	DT
cord-350836-1enteev7	369	41	serine	serine	NN
cord-350836-1enteev7	369	42	/	/	SYM
cord-350836-1enteev7	369	43	threonineprotein	threonineprotein	NNP
cord-350836-1enteev7	369	44	kinase	kinase	NNP
cord-350836-1enteev7	369	45	1	1	CD
cord-350836-1enteev7	369	46	(	(	-LRB-
cord-350836-1enteev7	369	47	TBK1	TBK1	NNP
cord-350836-1enteev7	369	48	)	)	-RRB-
cord-350836-1enteev7	369	49	(	(	-LRB-
cord-350836-1enteev7	369	50	305	305	CD
cord-350836-1enteev7	369	51	)	)	-RRB-
cord-350836-1enteev7	369	52	(	(	-LRB-
cord-350836-1enteev7	369	53	306	306	CD
cord-350836-1enteev7	369	54	)	)	-RRB-
cord-350836-1enteev7	369	55	(	(	-LRB-
cord-350836-1enteev7	369	56	307	307	CD
cord-350836-1enteev7	369	57	)	)	-RRB-
cord-350836-1enteev7	369	58	(	(	-LRB-
cord-350836-1enteev7	369	59	308	308	CD
cord-350836-1enteev7	369	60	)	)	-RRB-
cord-350836-1enteev7	369	61	(	(	-LRB-
cord-350836-1enteev7	369	62	309	309	CD
cord-350836-1enteev7	369	63	)	)	-RRB-
cord-350836-1enteev7	369	64	and	and	CC
cord-350836-1enteev7	369	65	the	the	DT
cord-350836-1enteev7	369	66	oligoadenylate	oligoadenylate	NNP
cord-350836-1enteev7	369	67	synthetase	synthetase	NNP
cord-350836-1enteev7	369	68	L	L	NNP
cord-350836-1enteev7	369	69	(	(	-LRB-
cord-350836-1enteev7	369	70	OASL	OASL	NNP
cord-350836-1enteev7	369	71	)	)	-RRB-
cord-350836-1enteev7	369	72	(	(	-LRB-
cord-350836-1enteev7	369	73	310	310	CD
cord-350836-1enteev7	369	74	)	)	-RRB-
cord-350836-1enteev7	369	75	.	.	.
cord-350836-1enteev7	370	1	PACT	pact	NN
cord-350836-1enteev7	370	2	in	in	IN
cord-350836-1enteev7	370	3	particular	particular	JJ
cord-350836-1enteev7	370	4	has	have	VBZ
cord-350836-1enteev7	370	5	some	some	DT
cord-350836-1enteev7	370	6	functional	functional	JJ
cord-350836-1enteev7	370	7	similarities	similarity	NNS
cord-350836-1enteev7	370	8	to	to	TO
cord-350836-1enteev7	370	9	RIG	rig	NN
cord-350836-1enteev7	370	10	-	-	:
cord-350836-1enteev7	370	11	I	-PRON-	PRP
cord-350836-1enteev7	370	12	,	,	,
cord-350836-1enteev7	370	13	as	as	IN
cord-350836-1enteev7	370	14	they	-PRON-	PRP
cord-350836-1enteev7	370	15	each	each	DT
cord-350836-1enteev7	370	16	contain	contain	VBP
cord-350836-1enteev7	370	17	three	three	CD
cord-350836-1enteev7	370	18	distinct	distinct	JJ
cord-350836-1enteev7	370	19	RNA	RNA	NNP
cord-350836-1enteev7	370	20	binding	binding	NN
cord-350836-1enteev7	370	21	domains	domain	NNS
cord-350836-1enteev7	370	22	(	(	-LRB-
cord-350836-1enteev7	370	23	311	311	CD
cord-350836-1enteev7	370	24	)	)	-RRB-
cord-350836-1enteev7	370	25	and	and	CC
cord-350836-1enteev7	370	26	interact	interact	VB
cord-350836-1enteev7	370	27	with	with	IN
cord-350836-1enteev7	370	28	many	many	JJ
cord-350836-1enteev7	370	29	of	of	IN
cord-350836-1enteev7	370	30	the	the	DT
cord-350836-1enteev7	370	31	same	same	JJ
cord-350836-1enteev7	370	32	cellular	cellular	JJ
cord-350836-1enteev7	370	33	co	co	NNS
cord-350836-1enteev7	370	34	-	-	NNS
cord-350836-1enteev7	370	35	factors	factor	NNS
cord-350836-1enteev7	370	36	,	,	,
cord-350836-1enteev7	370	37	such	such	JJ
cord-350836-1enteev7	370	38	as	as	IN
cord-350836-1enteev7	370	39	PKR	PKR	NNP
cord-350836-1enteev7	370	40	(	(	-LRB-
cord-350836-1enteev7	370	41	312	312	CD
cord-350836-1enteev7	370	42	)	)	-RRB-
cord-350836-1enteev7	370	43	and	and	CC
cord-350836-1enteev7	370	44	Dicer	Dicer	NNP
cord-350836-1enteev7	370	45	(	(	-LRB-
cord-350836-1enteev7	370	46	312	312	CD
cord-350836-1enteev7	370	47	,	,	,
cord-350836-1enteev7	370	48	313	313	CD
cord-350836-1enteev7	370	49	)	)	-RRB-
cord-350836-1enteev7	370	50	.	.	.
cord-350836-1enteev7	371	1	Because	because	IN
cord-350836-1enteev7	371	2	of	of	IN
cord-350836-1enteev7	371	3	the	the	DT
cord-350836-1enteev7	371	4	important	important	JJ
cord-350836-1enteev7	371	5	role	role	NN
cord-350836-1enteev7	371	6	of	of	IN
cord-350836-1enteev7	371	7	PACT	pact	NN
cord-350836-1enteev7	371	8	in	in	IN
cord-350836-1enteev7	371	9	augmenting	augment	VBG
cord-350836-1enteev7	371	10	RIG	rig	NN
cord-350836-1enteev7	371	11	-	-	:
cord-350836-1enteev7	371	12	I	-PRON-	PRP
cord-350836-1enteev7	371	13	function	function	VBP
cord-350836-1enteev7	371	14	,	,	,
cord-350836-1enteev7	371	15	it	-PRON-	PRP
cord-350836-1enteev7	371	16	is	be	VBZ
cord-350836-1enteev7	371	17	a	a	DT
cord-350836-1enteev7	371	18	prime	prime	JJ
cord-350836-1enteev7	371	19	target	target	NN
cord-350836-1enteev7	371	20	for	for	IN
cord-350836-1enteev7	371	21	inhibition	inhibition	NN
cord-350836-1enteev7	371	22	of	of	IN
cord-350836-1enteev7	371	23	RIG	rig	NN
cord-350836-1enteev7	372	1	-I	-i	DT
cord-350836-1enteev7	372	2	signaling	signal	VBG
cord-350836-1enteev7	372	3	by	by	IN
cord-350836-1enteev7	372	4	several	several	JJ
cord-350836-1enteev7	372	5	viral	viral	JJ
cord-350836-1enteev7	372	6	proteins	protein	NNS
cord-350836-1enteev7	372	7	from	from	IN
cord-350836-1enteev7	372	8	diverse	diverse	JJ
cord-350836-1enteev7	372	9	families	family	NNS
cord-350836-1enteev7	372	10	of	of	IN
cord-350836-1enteev7	372	11	viruses	virus	NNS
cord-350836-1enteev7	372	12	(	(	-LRB-
cord-350836-1enteev7	372	13	314	314	CD
cord-350836-1enteev7	372	14	)	)	-RRB-
cord-350836-1enteev7	372	15	(	(	-LRB-
cord-350836-1enteev7	372	16	315	315	CD
cord-350836-1enteev7	372	17	)	)	-RRB-
cord-350836-1enteev7	373	1	(	(	-LRB-
cord-350836-1enteev7	373	2	316	316	CD
cord-350836-1enteev7	373	3	)	)	-RRB-
cord-350836-1enteev7	373	4	,	,	,
cord-350836-1enteev7	373	5	the	the	DT
cord-350836-1enteev7	373	6	molecular	molecular	JJ
cord-350836-1enteev7	373	7	mechanisms	mechanism	NNS
cord-350836-1enteev7	373	8	of	of	IN
cord-350836-1enteev7	373	9	PACT	pact	NN
cord-350836-1enteev7	373	10	inhibition	inhibition	NN
cord-350836-1enteev7	373	11	by	by	IN
cord-350836-1enteev7	373	12	these	these	DT
cord-350836-1enteev7	373	13	viral	viral	JJ
cord-350836-1enteev7	373	14	proteins	protein	NNS
cord-350836-1enteev7	373	15	can	can	MD
cord-350836-1enteev7	373	16	vary	vary	VB
cord-350836-1enteev7	373	17	and	and	CC
cord-350836-1enteev7	373	18	still	still	RB
cord-350836-1enteev7	373	19	need	need	VB
cord-350836-1enteev7	373	20	to	to	TO
cord-350836-1enteev7	373	21	be	be	VB
cord-350836-1enteev7	373	22	characterized	characterize	VBN
cord-350836-1enteev7	373	23	in	in	IN
cord-350836-1enteev7	373	24	detail	detail	NN
cord-350836-1enteev7	373	25	in	in	IN
cord-350836-1enteev7	373	26	future	future	JJ
cord-350836-1enteev7	373	27	studies	study	NNS
cord-350836-1enteev7	373	28	.	.	.
cord-350836-1enteev7	374	1	Similarly	similarly	RB
cord-350836-1enteev7	374	2	,	,	,
cord-350836-1enteev7	374	3	the	the	DT
cord-350836-1enteev7	374	4	host	host	NN
cord-350836-1enteev7	374	5	ribonucleoprotein	ribonucleoprotein	NN
cord-350836-1enteev7	374	6	RAVER1	RAVER1	NNP
cord-350836-1enteev7	374	7	can	can	MD
cord-350836-1enteev7	374	8	increase	increase	VB
cord-350836-1enteev7	374	9	affinity	affinity	NN
cord-350836-1enteev7	374	10	of	of	IN
cord-350836-1enteev7	374	11	MDA5	MDA5	NNP
cord-350836-1enteev7	374	12	for	for	IN
cord-350836-1enteev7	374	13	dsRNA	dsRNA	NNS
cord-350836-1enteev7	374	14	(	(	-LRB-
cord-350836-1enteev7	374	15	317	317	CD
cord-350836-1enteev7	374	16	)	)	-RRB-
cord-350836-1enteev7	374	17	,	,	,
cord-350836-1enteev7	374	18	and	and	CC
cord-350836-1enteev7	374	19	the	the	DT
cord-350836-1enteev7	374	20	zinc	zinc	NN
cord-350836-1enteev7	374	21	-	-	HYPH
cord-350836-1enteev7	374	22	finger	finger	NN
cord-350836-1enteev7	374	23	protein	protein	NN
cord-350836-1enteev7	374	24	ZCCHC3	zcchc3	NN
cord-350836-1enteev7	374	25	has	have	VBZ
cord-350836-1enteev7	374	26	recently	recently	RB
cord-350836-1enteev7	374	27	been	be	VBN
cord-350836-1enteev7	374	28	found	find	VBN
cord-350836-1enteev7	374	29	do	do	VBP
cord-350836-1enteev7	374	30	so	so	RB
cord-350836-1enteev7	374	31	for	for	IN
cord-350836-1enteev7	374	32	both	both	DT
cord-350836-1enteev7	374	33	RIG	rig	NN
cord-350836-1enteev7	374	34	-	-	:
cord-350836-1enteev7	374	35	I	I	NNP
cord-350836-1enteev7	374	36	and	and	CC
cord-350836-1enteev7	374	37	MDA5	MDA5	NNP
cord-350836-1enteev7	374	38	(	(	-LRB-
cord-350836-1enteev7	374	39	125	125	CD
cord-350836-1enteev7	374	40	)	)	-RRB-
cord-350836-1enteev7	374	41	in	in	IN
cord-350836-1enteev7	374	42	similar	similar	JJ
cord-350836-1enteev7	374	43	mechanisms	mechanism	NNS
cord-350836-1enteev7	374	44	to	to	IN
cord-350836-1enteev7	374	45	the	the	DT
cord-350836-1enteev7	374	46	other	other	JJ
cord-350836-1enteev7	374	47	known	know	VBN
cord-350836-1enteev7	374	48	RNA	rna	NN
cord-350836-1enteev7	374	49	-	-	HYPH
cord-350836-1enteev7	374	50	binding	bind	VBG
cord-350836-1enteev7	374	51	proteins	protein	NNS
cord-350836-1enteev7	374	52	.	.	.
cord-350836-1enteev7	375	1	On	on	IN
cord-350836-1enteev7	375	2	the	the	DT
cord-350836-1enteev7	375	3	contrary	contrary	NN
cord-350836-1enteev7	375	4	,	,	,
cord-350836-1enteev7	375	5	the	the	DT
cord-350836-1enteev7	375	6	human	human	JJ
cord-350836-1enteev7	375	7	hemoglobin	hemoglobin	NN
cord-350836-1enteev7	375	8	subunit	subunit	NN
cord-350836-1enteev7	375	9	beta	beta	NN
cord-350836-1enteev7	375	10	(	(	-LRB-
cord-350836-1enteev7	375	11	HB	HB	NNP
cord-350836-1enteev7	375	12	)	)	-RRB-
cord-350836-1enteev7	375	13	has	have	VBZ
cord-350836-1enteev7	375	14	recently	recently	RB
cord-350836-1enteev7	375	15	been	be	VBN
cord-350836-1enteev7	375	16	suggested	suggest	VBN
cord-350836-1enteev7	375	17	to	to	TO
cord-350836-1enteev7	375	18	decrease	decrease	VB
cord-350836-1enteev7	375	19	MDA5	MDA5	NNP
cord-350836-1enteev7	375	20	signaling	signal	VBG
cord-350836-1enteev7	375	21	by	by	IN
cord-350836-1enteev7	375	22	competing	compete	VBG
cord-350836-1enteev7	375	23	for	for	IN
cord-350836-1enteev7	375	24	long	long	JJ
cord-350836-1enteev7	375	25	dsRNA	dsrna	NN
cord-350836-1enteev7	375	26	,	,	,
cord-350836-1enteev7	375	27	while	while	IN
cord-350836-1enteev7	375	28	HB	HB	NNP
cord-350836-1enteev7	375	29	can	can	MD
cord-350836-1enteev7	375	30	enhance	enhance	VB
cord-350836-1enteev7	375	31	RIG	rig	NN
cord-350836-1enteev7	375	32	-	-	:
cord-350836-1enteev7	375	33	I	i	NN
cord-350836-1enteev7	375	34	signaling	signal	VBG
cord-350836-1enteev7	375	35	by	by	IN
cord-350836-1enteev7	375	36	increasing	increase	VBG
cord-350836-1enteev7	375	37	K63	K63	NNP
cord-350836-1enteev7	375	38	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	375	39	on	on	IN
cord-350836-1enteev7	375	40	RIG	rig	NN
cord-350836-1enteev7	375	41	-	-	:
cord-350836-1enteev7	375	42	I	i	NN
cord-350836-1enteev7	375	43	(	(	-LRB-
cord-350836-1enteev7	375	44	318	318	CD
cord-350836-1enteev7	375	45	)	)	-RRB-
cord-350836-1enteev7	375	46	.	.	.
cord-350836-1enteev7	376	1	Several	several	JJ
cord-350836-1enteev7	376	2	host	host	NN
cord-350836-1enteev7	376	3	factors	factor	NNS
cord-350836-1enteev7	376	4	interacting	interact	VBG
cord-350836-1enteev7	376	5	with	with	IN
cord-350836-1enteev7	376	6	RIG	rig	NN
cord-350836-1enteev7	376	7	-	-	:
cord-350836-1enteev7	376	8	I	I	NNP
cord-350836-1enteev7	376	9	and	and	CC
cord-350836-1enteev7	376	10	MDA5	MDA5	NNP
cord-350836-1enteev7	376	11	do	do	VBP
cord-350836-1enteev7	376	12	so	so	RB
cord-350836-1enteev7	376	13	by	by	IN
cord-350836-1enteev7	376	14	yet	yet	RB
cord-350836-1enteev7	376	15	undescribed	undescribed	JJ
cord-350836-1enteev7	376	16	mechanisms	mechanism	NNS
cord-350836-1enteev7	376	17	.	.	.
cord-350836-1enteev7	377	1	PKR	PKR	NNP
cord-350836-1enteev7	377	2	[	[	-LRB-
cord-350836-1enteev7	377	3	which	which	WDT
cord-350836-1enteev7	377	4	is	be	VBZ
cord-350836-1enteev7	377	5	also	also	RB
cord-350836-1enteev7	377	6	activated	activate	VBN
cord-350836-1enteev7	377	7	by	by	IN
cord-350836-1enteev7	377	8	PACT	PACT	NNP
cord-350836-1enteev7	377	9	(	(	-LRB-
cord-350836-1enteev7	377	10	319	319	CD
cord-350836-1enteev7	377	11	,	,	,
cord-350836-1enteev7	377	12	320	320	CD
cord-350836-1enteev7	377	13	)	)	-RRB-
cord-350836-1enteev7	377	14	and	and	CC
cord-350836-1enteev7	377	15	is	be	VBZ
cord-350836-1enteev7	377	16	sequestered	sequester	VBN
cord-350836-1enteev7	377	17	by	by	IN
cord-350836-1enteev7	377	18	the	the	DT
cord-350836-1enteev7	377	19	cellular	cellular	JJ
cord-350836-1enteev7	377	20	helicase	helicase	NN
cord-350836-1enteev7	377	21	DHX36	DHX36	NNP
cord-350836-1enteev7	377	22	protein	protein	NN
cord-350836-1enteev7	377	23	to	to	TO
cord-350836-1enteev7	377	24	form	form	VB
cord-350836-1enteev7	377	25	stress	stress	NN
cord-350836-1enteev7	377	26	granules	granule	NNS
cord-350836-1enteev7	377	27	(	(	-LRB-
cord-350836-1enteev7	377	28	321	321	CD
cord-350836-1enteev7	377	29	,	,	,
cord-350836-1enteev7	377	30	322	322	CD
cord-350836-1enteev7	377	31	)	)	-RRB-
cord-350836-1enteev7	377	32	along	along	IN
cord-350836-1enteev7	377	33	with	with	IN
cord-350836-1enteev7	377	34	RIG	rig	NN
cord-350836-1enteev7	377	35	-	-	:
cord-350836-1enteev7	377	36	I	i	NN
cord-350836-1enteev7	377	37	(	(	-LRB-
cord-350836-1enteev7	377	38	323	323	CD
cord-350836-1enteev7	377	39	,	,	,
cord-350836-1enteev7	377	40	324	324	CD
cord-350836-1enteev7	377	41	)	)	-RRB-
cord-350836-1enteev7	377	42	and	and	CC
cord-350836-1enteev7	377	43	TRIM25	TRIM25	NNP
cord-350836-1enteev7	377	44	(	(	-LRB-
cord-350836-1enteev7	377	45	324	324	CD
cord-350836-1enteev7	377	46	)	)	-RRB-
cord-350836-1enteev7	377	47	]	]	-RRB-
cord-350836-1enteev7	377	48	appears	appear	VBZ
cord-350836-1enteev7	377	49	to	to	TO
cord-350836-1enteev7	377	50	have	have	VB
cord-350836-1enteev7	377	51	a	a	DT
cord-350836-1enteev7	377	52	novel	novel	NN
cord-350836-1enteev7	377	53	and	and	CC
cord-350836-1enteev7	377	54	yet	yet	RB
cord-350836-1enteev7	377	55	uncharacterized	uncharacterized	JJ
cord-350836-1enteev7	377	56	function	function	NN
cord-350836-1enteev7	377	57	in	in	IN
cord-350836-1enteev7	377	58	enhancing	enhance	VBG
cord-350836-1enteev7	377	59	MDA5-dependent	MDA5-dependent	NNP
cord-350836-1enteev7	377	60	MAVS	MAVS	NNP
cord-350836-1enteev7	377	61	signaling	signal	VBG
cord-350836-1enteev7	377	62	that	that	WDT
cord-350836-1enteev7	377	63	is	be	VBZ
cord-350836-1enteev7	377	64	dependent	dependent	JJ
cord-350836-1enteev7	377	65	on	on	IN
cord-350836-1enteev7	377	66	the	the	DT
cord-350836-1enteev7	377	67	kinase	kinase	NN
cord-350836-1enteev7	377	68	activity	activity	NN
cord-350836-1enteev7	377	69	of	of	IN
cord-350836-1enteev7	377	70	PKR	PKR	NNP
cord-350836-1enteev7	377	71	(	(	-LRB-
cord-350836-1enteev7	377	72	325	325	CD
cord-350836-1enteev7	377	73	)	)	-RRB-
cord-350836-1enteev7	377	74	.	.	.
cord-350836-1enteev7	378	1	Additionally	additionally	RB
cord-350836-1enteev7	378	2	,	,	,
cord-350836-1enteev7	378	3	the	the	DT
cord-350836-1enteev7	378	4	porcine	porcine	JJ
cord-350836-1enteev7	378	5	Interferon	Interferon	NNP
cord-350836-1enteev7	378	6	-	-	HYPH
cord-350836-1enteev7	378	7	Inducible	Inducible	NNP
cord-350836-1enteev7	378	8	Oligoadenylate	Oligoadenylate	NNP
cord-350836-1enteev7	378	9	Synthetase	Synthetase	NNP
cord-350836-1enteev7	378	10	-	-	HYPH
cord-350836-1enteev7	378	11	like	like	JJ
cord-350836-1enteev7	378	12	protein	protein	NN
cord-350836-1enteev7	378	13	(	(	-LRB-
cord-350836-1enteev7	378	14	pOASL	pOASL	NNP
cord-350836-1enteev7	378	15	)	)	-RRB-
cord-350836-1enteev7	378	16	has	have	VBZ
cord-350836-1enteev7	378	17	also	also	RB
cord-350836-1enteev7	378	18	been	be	VBN
cord-350836-1enteev7	378	19	found	find	VBN
cord-350836-1enteev7	378	20	to	to	TO
cord-350836-1enteev7	378	21	interact	interact	VB
cord-350836-1enteev7	378	22	with	with	IN
cord-350836-1enteev7	378	23	and	and	CC
cord-350836-1enteev7	378	24	inhibit	inhibit	VB
cord-350836-1enteev7	378	25	MDA5	MDA5	NNP
cord-350836-1enteev7	378	26	by	by	IN
cord-350836-1enteev7	378	27	an	an	DT
cord-350836-1enteev7	378	28	unknown	unknown	JJ
cord-350836-1enteev7	378	29	mechanism	mechanism	NN
cord-350836-1enteev7	378	30	(	(	-LRB-
cord-350836-1enteev7	378	31	326	326	CD
cord-350836-1enteev7	378	32	)	)	-RRB-
cord-350836-1enteev7	378	33	.	.	.
cord-350836-1enteev7	379	1	The	the	DT
cord-350836-1enteev7	379	2	RIG	rig	NN
cord-350836-1enteev7	379	3	-	-	HYPH
cord-350836-1enteev7	379	4	I	-PRON-	PRP
cord-350836-1enteev7	379	5	CARD	card	NN
cord-350836-1enteev7	379	6	domain	domain	NN
cord-350836-1enteev7	379	7	interacts	interact	VBZ
cord-350836-1enteev7	379	8	with	with	IN
cord-350836-1enteev7	379	9	MAVS	MAVS	NNPS
cord-350836-1enteev7	379	10	to	to	TO
cord-350836-1enteev7	379	11	induce	induce	VB
cord-350836-1enteev7	379	12	interferon	interferon	NN
cord-350836-1enteev7	379	13	signaling	signal	VBG
cord-350836-1enteev7	379	14	,	,	,
cord-350836-1enteev7	379	15	so	so	IN
cord-350836-1enteev7	379	16	proteins	protein	NNS
cord-350836-1enteev7	379	17	that	that	WDT
cord-350836-1enteev7	379	18	disrupt	disrupt	VBP
cord-350836-1enteev7	379	19	this	this	DT
cord-350836-1enteev7	379	20	interaction	interaction	NN
cord-350836-1enteev7	379	21	[	[	-LRB-
cord-350836-1enteev7	379	22	as	as	IN
cord-350836-1enteev7	379	23	it	-PRON-	PRP
cord-350836-1enteev7	379	24	has	have	VBZ
cord-350836-1enteev7	379	25	been	be	VBN
cord-350836-1enteev7	379	26	proposed	propose	VBN
cord-350836-1enteev7	379	27	for	for	IN
cord-350836-1enteev7	379	28	the	the	DT
cord-350836-1enteev7	379	29	Atg5	Atg5	NNP
cord-350836-1enteev7	379	30	and	and	CC
cord-350836-1enteev7	379	31	Atg12	Atg12	NNP
cord-350836-1enteev7	379	32	autophagy	autophagy	NN
cord-350836-1enteev7	379	33	proteins	protein	NNS
cord-350836-1enteev7	379	34	(	(	-LRB-
cord-350836-1enteev7	379	35	59	59	CD
cord-350836-1enteev7	379	36	)	)	-RRB-
cord-350836-1enteev7	379	37	]	]	-RRB-
cord-350836-1enteev7	379	38	can	can	MD
cord-350836-1enteev7	379	39	specifically	specifically	RB
cord-350836-1enteev7	379	40	inhibit	inhibit	VB
cord-350836-1enteev7	379	41	RIG	rig	NN
cord-350836-1enteev7	379	42	-	-	:
cord-350836-1enteev7	379	43	I	-PRON-	PRP
cord-350836-1enteev7	379	44	signaling	signal	VBG
cord-350836-1enteev7	379	45	.	.	.
cord-350836-1enteev7	380	1	However	however	RB
cord-350836-1enteev7	380	2	,	,	,
cord-350836-1enteev7	380	3	other	other	JJ
cord-350836-1enteev7	380	4	cellular	cellular	JJ
cord-350836-1enteev7	380	5	proteins	protein	NNS
cord-350836-1enteev7	380	6	,	,	,
cord-350836-1enteev7	380	7	such	such	JJ
cord-350836-1enteev7	380	8	as	as	IN
cord-350836-1enteev7	380	9	the	the	DT
cord-350836-1enteev7	380	10	complement	complement	NN
cord-350836-1enteev7	380	11	protein	protein	NN
cord-350836-1enteev7	380	12	gC1qR	gC1qR	NNP
cord-350836-1enteev7	380	13	(	(	-LRB-
cord-350836-1enteev7	380	14	327	327	CD
cord-350836-1enteev7	380	15	)	)	-RRB-
cord-350836-1enteev7	380	16	and	and	CC
cord-350836-1enteev7	380	17	TARBP2	TARBP2	NNP
cord-350836-1enteev7	380	18	(	(	-LRB-
cord-350836-1enteev7	380	19	328	328	CD
cord-350836-1enteev7	380	20	)	)	-RRB-
cord-350836-1enteev7	380	21	that	that	WDT
cord-350836-1enteev7	380	22	interact	interact	VBP
cord-350836-1enteev7	380	23	directly	directly	RB
cord-350836-1enteev7	380	24	with	with	IN
cord-350836-1enteev7	380	25	MAVS	MAVS	NNPS
cord-350836-1enteev7	380	26	,	,	,
cord-350836-1enteev7	381	1	inhibit	inhibit	VB
cord-350836-1enteev7	381	2	both	both	CC
cord-350836-1enteev7	381	3	RIG	rig	NN
cord-350836-1enteev7	381	4	-	-	:
cord-350836-1enteev7	381	5	I	I	NNP
cord-350836-1enteev7	381	6	and	and	CC
cord-350836-1enteev7	381	7	MDA5	MDA5	NNP
cord-350836-1enteev7	381	8	.	.	.
cord-350836-1enteev7	382	1	Lactate	lactate	NN
cord-350836-1enteev7	382	2	and	and	CC
cord-350836-1enteev7	382	3	hexokinase	hexokinase	NNP
cord-350836-1enteev7	382	4	have	have	VBP
cord-350836-1enteev7	382	5	also	also	RB
cord-350836-1enteev7	382	6	recently	recently	RB
cord-350836-1enteev7	382	7	been	be	VBN
cord-350836-1enteev7	382	8	found	find	VBN
cord-350836-1enteev7	382	9	to	to	TO
cord-350836-1enteev7	382	10	inhibit	inhibit	VB
cord-350836-1enteev7	382	11	RIG	rig	NN
cord-350836-1enteev7	382	12	-	-	:
cord-350836-1enteev7	382	13	I	I	NNP
cord-350836-1enteev7	382	14	and	and	CC
cord-350836-1enteev7	382	15	MDA5	MDA5	NNP
cord-350836-1enteev7	382	16	by	by	IN
cord-350836-1enteev7	382	17	interacting	interact	VBG
cord-350836-1enteev7	382	18	with	with	IN
cord-350836-1enteev7	382	19	MAVS	MAVS	NNPS
cord-350836-1enteev7	382	20	,	,	,
cord-350836-1enteev7	382	21	which	which	WDT
cord-350836-1enteev7	382	22	may	may	MD
cord-350836-1enteev7	382	23	be	be	VB
cord-350836-1enteev7	382	24	significant	significant	JJ
cord-350836-1enteev7	382	25	in	in	IN
cord-350836-1enteev7	382	26	explaining	explain	VBG
cord-350836-1enteev7	382	27	the	the	DT
cord-350836-1enteev7	382	28	interplay	interplay	NN
cord-350836-1enteev7	382	29	between	between	IN
cord-350836-1enteev7	382	30	metabolism	metabolism	NN
cord-350836-1enteev7	382	31	and	and	CC
cord-350836-1enteev7	382	32	immune	immune	JJ
cord-350836-1enteev7	382	33	signaling	signaling	NN
cord-350836-1enteev7	382	34	as	as	IN
cord-350836-1enteev7	382	35	glycolysis	glycolysis	NN
cord-350836-1enteev7	382	36	was	be	VBD
cord-350836-1enteev7	382	37	found	find	VBN
cord-350836-1enteev7	382	38	to	to	TO
cord-350836-1enteev7	382	39	be	be	VB
cord-350836-1enteev7	382	40	greatly	greatly	RB
cord-350836-1enteev7	382	41	decreased	decrease	VBN
cord-350836-1enteev7	382	42	upon	upon	IN
cord-350836-1enteev7	382	43	RLR	RLR	NNP
cord-350836-1enteev7	382	44	signaling	signaling	NN
cord-350836-1enteev7	382	45	(	(	-LRB-
cord-350836-1enteev7	382	46	329	329	CD
cord-350836-1enteev7	382	47	)	)	-RRB-
cord-350836-1enteev7	382	48	.	.	.
cord-350836-1enteev7	383	1	Likewise	likewise	RB
cord-350836-1enteev7	383	2	,	,	,
cord-350836-1enteev7	383	3	cellular	cellular	JJ
cord-350836-1enteev7	383	4	proteins	protein	NNS
cord-350836-1enteev7	383	5	,	,	,
cord-350836-1enteev7	383	6	such	such	JJ
cord-350836-1enteev7	383	7	as	as	IN
cord-350836-1enteev7	383	8	NLRC5	NLRC5	NNP
cord-350836-1enteev7	383	9	(	(	-LRB-
cord-350836-1enteev7	383	10	330	330	CD
cord-350836-1enteev7	383	11	)	)	-RRB-
cord-350836-1enteev7	383	12	that	that	WDT
cord-350836-1enteev7	383	13	interacts	interact	VBZ
cord-350836-1enteev7	383	14	with	with	IN
cord-350836-1enteev7	383	15	the	the	DT
cord-350836-1enteev7	383	16	RIG	rig	NN
cord-350836-1enteev7	383	17	-	-	:
cord-350836-1enteev7	383	18	I	I	NNP
cord-350836-1enteev7	383	19	and	and	CC
cord-350836-1enteev7	383	20	MDA5	MDA5	NNP
cord-350836-1enteev7	383	21	CARD	card	NN
cord-350836-1enteev7	383	22	domains	domain	NNS
cord-350836-1enteev7	383	23	have	have	VBP
cord-350836-1enteev7	383	24	been	be	VBN
cord-350836-1enteev7	383	25	shown	show	VBN
cord-350836-1enteev7	383	26	to	to	TO
cord-350836-1enteev7	383	27	block	block	VB
cord-350836-1enteev7	383	28	interaction	interaction	NN
cord-350836-1enteev7	383	29	of	of	IN
cord-350836-1enteev7	383	30	both	both	DT
cord-350836-1enteev7	383	31	RIG	rig	NN
cord-350836-1enteev7	383	32	-	-	:
cord-350836-1enteev7	383	33	I	I	NNP
cord-350836-1enteev7	383	34	and	and	CC
cord-350836-1enteev7	383	35	MDA5	MDA5	NNP
cord-350836-1enteev7	383	36	with	with	IN
cord-350836-1enteev7	383	37	MAVS	MAVS	NNPS
cord-350836-1enteev7	383	38	.	.	.
cord-350836-1enteev7	384	1	Contrarily	contrarily	RB
cord-350836-1enteev7	384	2	,	,	,
cord-350836-1enteev7	384	3	DHX15	DHX15	NNP
cord-350836-1enteev7	384	4	has	have	VBZ
cord-350836-1enteev7	384	5	been	be	VBN
cord-350836-1enteev7	384	6	identified	identify	VBN
cord-350836-1enteev7	384	7	as	as	IN
cord-350836-1enteev7	384	8	a	a	DT
cord-350836-1enteev7	384	9	RIG	rig	NN
cord-350836-1enteev7	384	10	-	-	:
cord-350836-1enteev7	384	11	I	-PRON-	PRP
cord-350836-1enteev7	384	12	cofactor	cofactor	NN
cord-350836-1enteev7	384	13	that	that	WDT
cord-350836-1enteev7	384	14	interacts	interact	VBZ
cord-350836-1enteev7	384	15	with	with	IN
cord-350836-1enteev7	384	16	the	the	DT
cord-350836-1enteev7	384	17	RIG	rig	NN
cord-350836-1enteev7	384	18	-	-	HYPH
cord-350836-1enteev7	384	19	I	i	NN
cord-350836-1enteev7	384	20	CARD	card	NN
cord-350836-1enteev7	384	21	domains	domain	NNS
cord-350836-1enteev7	384	22	and	and	CC
cord-350836-1enteev7	384	23	with	with	IN
cord-350836-1enteev7	384	24	PAMP	PAMP	NNP
cord-350836-1enteev7	384	25	(	(	-LRB-
cord-350836-1enteev7	384	26	dsRNA	dsrna	NN
cord-350836-1enteev7	384	27	)	)	-RRB-
cord-350836-1enteev7	384	28	,	,	,
cord-350836-1enteev7	384	29	thereby	thereby	RB
cord-350836-1enteev7	384	30	increasing	increase	VBG
cord-350836-1enteev7	384	31	RIG	rig	NN
cord-350836-1enteev7	384	32	-	-	:
cord-350836-1enteev7	384	33	I	-PRON-	PRP
cord-350836-1enteev7	384	34	ATPase	ATPase	NNP
cord-350836-1enteev7	384	35	activity	activity	NN
cord-350836-1enteev7	384	36	(	(	-LRB-
cord-350836-1enteev7	384	37	331	331	CD
cord-350836-1enteev7	384	38	)	)	-RRB-
cord-350836-1enteev7	384	39	.	.	.
cord-350836-1enteev7	385	1	Additionally	additionally	RB
cord-350836-1enteev7	385	2	,	,	,
cord-350836-1enteev7	385	3	ADP	ADP	NNP
cord-350836-1enteev7	385	4	-	-	HYPH
cord-350836-1enteev7	385	5	ribosylation	ribosylation	NN
cord-350836-1enteev7	385	6	factor	factor	NN
cord-350836-1enteev7	385	7	proteins	protein	NNS
cord-350836-1enteev7	385	8	can	can	MD
cord-350836-1enteev7	385	9	block	block	VB
cord-350836-1enteev7	385	10	RIG	rig	NN
cord-350836-1enteev7	385	11	-	-	:
cord-350836-1enteev7	385	12	I	I	NNP
cord-350836-1enteev7	385	13	and	and	CC
cord-350836-1enteev7	385	14	MDA5	MDA5	NNP
cord-350836-1enteev7	385	15	from	from	IN
cord-350836-1enteev7	385	16	interacting	interact	VBG
cord-350836-1enteev7	385	17	with	with	IN
cord-350836-1enteev7	385	18	PAMPs	pamp	NNS
cord-350836-1enteev7	385	19	and	and	CC
cord-350836-1enteev7	385	20	thereby	thereby	RB
cord-350836-1enteev7	385	21	inhibit	inhibit	VB
cord-350836-1enteev7	385	22	their	-PRON-	PRP$
cord-350836-1enteev7	385	23	activation	activation	NN
cord-350836-1enteev7	385	24	(	(	-LRB-
cord-350836-1enteev7	385	25	332	332	CD
cord-350836-1enteev7	385	26	,	,	,
cord-350836-1enteev7	385	27	333	333	CD
cord-350836-1enteev7	385	28	)	)	-RRB-
cord-350836-1enteev7	385	29	.	.	.
cord-350836-1enteev7	386	1	Lastly	lastly	RB
cord-350836-1enteev7	386	2	,	,	,
cord-350836-1enteev7	386	3	the	the	DT
cord-350836-1enteev7	386	4	green	green	JJ
cord-350836-1enteev7	386	5	tea	tea	NN
cord-350836-1enteev7	386	6	molecule	molecule	NN
cord-350836-1enteev7	386	7	EGCG	EGCG	NNP
cord-350836-1enteev7	386	8	has	have	VBZ
cord-350836-1enteev7	386	9	also	also	RB
cord-350836-1enteev7	386	10	been	be	VBN
cord-350836-1enteev7	386	11	shown	show	VBN
cord-350836-1enteev7	386	12	to	to	TO
cord-350836-1enteev7	386	13	inhibit	inhibit	VB
cord-350836-1enteev7	386	14	the	the	DT
cord-350836-1enteev7	386	15	ATPase	ATPase	NNP
cord-350836-1enteev7	386	16	function	function	NN
cord-350836-1enteev7	386	17	of	of	IN
cord-350836-1enteev7	386	18	RIG	rig	NN
cord-350836-1enteev7	386	19	-	-	:
cord-350836-1enteev7	386	20	I	i	NN
cord-350836-1enteev7	386	21	(	(	-LRB-
cord-350836-1enteev7	386	22	334	334	CD
cord-350836-1enteev7	386	23	)	)	-RRB-
cord-350836-1enteev7	386	24	.	.	.
cord-350836-1enteev7	387	1	The	the	DT
cord-350836-1enteev7	387	2	similarities	similarity	NNS
cord-350836-1enteev7	387	3	and	and	CC
cord-350836-1enteev7	387	4	differences	difference	NNS
cord-350836-1enteev7	387	5	between	between	IN
cord-350836-1enteev7	387	6	RIG	rig	NN
cord-350836-1enteev7	387	7	-	-	:
cord-350836-1enteev7	387	8	I	I	NNP
cord-350836-1enteev7	387	9	and	and	CC
cord-350836-1enteev7	387	10	MDA5	mda5	JJ
cord-350836-1enteev7	387	11	modulations	modulation	NNS
cord-350836-1enteev7	387	12	and	and	CC
cord-350836-1enteev7	387	13	signaling	signaling	NN
cord-350836-1enteev7	387	14	are	be	VBP
cord-350836-1enteev7	387	15	complex	complex	JJ
cord-350836-1enteev7	387	16	and	and	CC
cord-350836-1enteev7	387	17	will	will	MD
cord-350836-1enteev7	387	18	need	need	VB
cord-350836-1enteev7	387	19	to	to	TO
cord-350836-1enteev7	387	20	be	be	VB
cord-350836-1enteev7	387	21	elucidated	elucidate	VBN
cord-350836-1enteev7	387	22	further	far	RBR
cord-350836-1enteev7	387	23	in	in	IN
cord-350836-1enteev7	387	24	future	future	JJ
cord-350836-1enteev7	387	25	studies	study	NNS
cord-350836-1enteev7	387	26	.	.	.
cord-350836-1enteev7	388	1	Despite	despite	IN
cord-350836-1enteev7	388	2	their	-PRON-	PRP$
cord-350836-1enteev7	388	3	structural	structural	JJ
cord-350836-1enteev7	388	4	and	and	CC
cord-350836-1enteev7	388	5	mechanistic	mechanistic	JJ
cord-350836-1enteev7	388	6	differences	difference	NNS
cord-350836-1enteev7	388	7	,	,	,
cord-350836-1enteev7	388	8	it	-PRON-	PRP
cord-350836-1enteev7	388	9	is	be	VBZ
cord-350836-1enteev7	388	10	important	important	JJ
cord-350836-1enteev7	388	11	to	to	TO
cord-350836-1enteev7	388	12	emphasize	emphasize	VB
cord-350836-1enteev7	388	13	that	that	IN
cord-350836-1enteev7	388	14	existing	exist	VBG
cord-350836-1enteev7	388	15	phylogenetic	phylogenetic	JJ
cord-350836-1enteev7	388	16	analysis	analysis	NN
cord-350836-1enteev7	388	17	indicates	indicate	VBZ
cord-350836-1enteev7	388	18	that	that	IN
cord-350836-1enteev7	388	19	RIG	rig	NN
cord-350836-1enteev7	388	20	-	-	:
cord-350836-1enteev7	388	21	I	I	NNP
cord-350836-1enteev7	388	22	and	and	CC
cord-350836-1enteev7	388	23	MDA5	MDA5	NNP
cord-350836-1enteev7	388	24	come	come	VBP
cord-350836-1enteev7	388	25	from	from	IN
cord-350836-1enteev7	388	26	a	a	DT
cord-350836-1enteev7	388	27	common	common	JJ
cord-350836-1enteev7	388	28	origin	origin	NN
cord-350836-1enteev7	388	29	that	that	WDT
cord-350836-1enteev7	388	30	is	be	VBZ
cord-350836-1enteev7	388	31	also	also	RB
cord-350836-1enteev7	388	32	shared	share	VBN
cord-350836-1enteev7	388	33	among	among	IN
cord-350836-1enteev7	388	34	several	several	JJ
cord-350836-1enteev7	388	35	other	other	JJ
cord-350836-1enteev7	388	36	protein	protein	NN
cord-350836-1enteev7	388	37	families	family	NNS
cord-350836-1enteev7	388	38	(	(	-LRB-
cord-350836-1enteev7	388	39	Figure	Figure	NNP
cord-350836-1enteev7	388	40	7	7	CD
cord-350836-1enteev7	388	41	)	)	-RRB-
cord-350836-1enteev7	388	42	.	.	.
cord-350836-1enteev7	389	1	The	the	DT
cord-350836-1enteev7	389	2	linkage	linkage	NN
cord-350836-1enteev7	389	3	of	of	IN
cord-350836-1enteev7	389	4	the	the	DT
cord-350836-1enteev7	389	5	helicase	helicase	NN
cord-350836-1enteev7	389	6	and	and	CC
cord-350836-1enteev7	389	7	DExD	DExD	NNS
cord-350836-1enteev7	389	8	/	/	SYM
cord-350836-1enteev7	389	9	H	h	NN
cord-350836-1enteev7	389	10	box	box	NN
cord-350836-1enteev7	389	11	protein	protein	NN
cord-350836-1enteev7	389	12	appear	appear	VBP
cord-350836-1enteev7	389	13	to	to	TO
cord-350836-1enteev7	389	14	be	be	VB
cord-350836-1enteev7	389	15	ancient	ancient	JJ
cord-350836-1enteev7	389	16	,	,	,
cord-350836-1enteev7	389	17	as	as	IN
cord-350836-1enteev7	389	18	orthologs	ortholog	NNS
cord-350836-1enteev7	389	19	of	of	IN
cord-350836-1enteev7	389	20	these	these	DT
cord-350836-1enteev7	389	21	proteins	protein	NNS
cord-350836-1enteev7	389	22	are	be	VBP
cord-350836-1enteev7	389	23	found	find	VBN
cord-350836-1enteev7	389	24	in	in	IN
cord-350836-1enteev7	389	25	the	the	DT
cord-350836-1enteev7	389	26	Archaea	Archaea	NNP
cord-350836-1enteev7	389	27	kingdom	kingdom	NN
cord-350836-1enteev7	389	28	(	(	-LRB-
cord-350836-1enteev7	389	29	335	335	CD
cord-350836-1enteev7	389	30	,	,	,
cord-350836-1enteev7	389	31	336	336	CD
cord-350836-1enteev7	389	32	)	)	-RRB-
cord-350836-1enteev7	389	33	.	.	.
cord-350836-1enteev7	390	1	MDA5	mda5	JJ
cord-350836-1enteev7	390	2	orthologs	ortholog	NNS
cord-350836-1enteev7	390	3	are	be	VBP
cord-350836-1enteev7	390	4	found	find	VBN
cord-350836-1enteev7	390	5	in	in	IN
cord-350836-1enteev7	390	6	most	most	JJS
cord-350836-1enteev7	390	7	vertebrates	vertebrate	NNS
cord-350836-1enteev7	390	8	(	(	-LRB-
cord-350836-1enteev7	390	9	184	184	CD
cord-350836-1enteev7	390	10	)	)	-RRB-
cord-350836-1enteev7	390	11	,	,	,
cord-350836-1enteev7	390	12	while	while	IN
cord-350836-1enteev7	390	13	RIG	rig	NN
cord-350836-1enteev7	390	14	-	-	:
cord-350836-1enteev7	390	15	I	-PRON-	PRP
cord-350836-1enteev7	390	16	orthologs	ortholog	NNS
cord-350836-1enteev7	390	17	are	be	VBP
cord-350836-1enteev7	390	18	only	only	RB
cord-350836-1enteev7	390	19	found	find	VBN
cord-350836-1enteev7	390	20	in	in	IN
cord-350836-1enteev7	390	21	mammals	mammal	NNS
cord-350836-1enteev7	390	22	,	,	,
cord-350836-1enteev7	390	23	ducks	duck	NNS
cord-350836-1enteev7	390	24	,	,	,
cord-350836-1enteev7	390	25	geese	goose	NNS
cord-350836-1enteev7	390	26	and	and	CC
cord-350836-1enteev7	390	27	some	some	DT
cord-350836-1enteev7	390	28	selected	select	VBN
cord-350836-1enteev7	390	29	fish	fish	NN
cord-350836-1enteev7	390	30	and	and	CC
cord-350836-1enteev7	390	31	reptiles	reptile	NNS
cord-350836-1enteev7	390	32	(	(	-LRB-
cord-350836-1enteev7	390	33	184	184	CD
cord-350836-1enteev7	390	34	,	,	,
cord-350836-1enteev7	390	35	(	(	-LRB-
cord-350836-1enteev7	390	36	337	337	CD
cord-350836-1enteev7	390	37	)	)	-RRB-
cord-350836-1enteev7	390	38	(	(	-LRB-
cord-350836-1enteev7	390	39	338	338	CD
cord-350836-1enteev7	390	40	)	)	-RRB-
cord-350836-1enteev7	390	41	(	(	-LRB-
cord-350836-1enteev7	390	42	339	339	CD
cord-350836-1enteev7	390	43	)	)	-RRB-
cord-350836-1enteev7	390	44	(	(	-LRB-
cord-350836-1enteev7	390	45	340	340	CD
cord-350836-1enteev7	390	46	)	)	-RRB-
cord-350836-1enteev7	390	47	(	(	-LRB-
cord-350836-1enteev7	390	48	341	341	CD
cord-350836-1enteev7	390	49	)	)	-RRB-
cord-350836-1enteev7	390	50	(	(	-LRB-
cord-350836-1enteev7	390	51	342	342	CD
cord-350836-1enteev7	390	52	)	)	-RRB-
cord-350836-1enteev7	390	53	(	(	-LRB-
cord-350836-1enteev7	390	54	343	343	CD
cord-350836-1enteev7	390	55	)	)	-RRB-
cord-350836-1enteev7	391	1	(	(	-LRB-
cord-350836-1enteev7	391	2	Figures	figure	NNS
cord-350836-1enteev7	391	3	2	2	CD
cord-350836-1enteev7	391	4	,	,	,
cord-350836-1enteev7	391	5	7	7	CD
cord-350836-1enteev7	391	6	)	)	-RRB-
cord-350836-1enteev7	391	7	.	.	.
cord-350836-1enteev7	392	1	It	-PRON-	PRP
cord-350836-1enteev7	392	2	is	be	VBZ
cord-350836-1enteev7	392	3	therefore	therefore	RB
cord-350836-1enteev7	392	4	likely	likely	JJ
cord-350836-1enteev7	392	5	that	that	IN
cord-350836-1enteev7	392	6	MDA5	MDA5	NNP
cord-350836-1enteev7	392	7	evolved	evolve	VBD
cord-350836-1enteev7	392	8	first	first	RB
cord-350836-1enteev7	392	9	,	,	,
cord-350836-1enteev7	392	10	perhaps	perhaps	RB
cord-350836-1enteev7	392	11	from	from	IN
cord-350836-1enteev7	392	12	a	a	DT
cord-350836-1enteev7	392	13	common	common	JJ
cord-350836-1enteev7	392	14	ancestor	ancestor	NN
cord-350836-1enteev7	392	15	with	with	IN
cord-350836-1enteev7	392	16	the	the	DT
cord-350836-1enteev7	392	17	closely	closely	RB
cord-350836-1enteev7	392	18	related	relate	VBN
cord-350836-1enteev7	392	19	LGP2	LGP2	NNP
cord-350836-1enteev7	392	20	helicase	helicase	NN
cord-350836-1enteev7	392	21	family	family	NN
cord-350836-1enteev7	392	22	(	(	-LRB-
cord-350836-1enteev7	392	23	184	184	CD
cord-350836-1enteev7	392	24	)	)	-RRB-
cord-350836-1enteev7	392	25	,	,	,
cord-350836-1enteev7	392	26	which	which	WDT
cord-350836-1enteev7	392	27	is	be	VBZ
cord-350836-1enteev7	392	28	structural	structural	JJ
cord-350836-1enteev7	392	29	similar	similar	JJ
cord-350836-1enteev7	392	30	to	to	IN
cord-350836-1enteev7	392	31	RIG	rig	NN
cord-350836-1enteev7	392	32	-	-	:
cord-350836-1enteev7	392	33	I	I	NNP
cord-350836-1enteev7	392	34	and	and	CC
cord-350836-1enteev7	392	35	MDA5	MDA5	NNP
cord-350836-1enteev7	392	36	but	but	CC
cord-350836-1enteev7	392	37	lacks	lack	VBZ
cord-350836-1enteev7	392	38	the	the	DT
cord-350836-1enteev7	392	39	CARD	card	NN
cord-350836-1enteev7	392	40	domains	domain	NNS
cord-350836-1enteev7	392	41	at	at	IN
cord-350836-1enteev7	392	42	its	-PRON-	PRP$
cord-350836-1enteev7	392	43	N	n	CD
cord-350836-1enteev7	392	44	terminus	terminus	NN
cord-350836-1enteev7	392	45	(	(	-LRB-
cord-350836-1enteev7	392	46	185	185	CD
cord-350836-1enteev7	392	47	)	)	-RRB-
cord-350836-1enteev7	392	48	.	.	.
cord-350836-1enteev7	393	1	LGP2	LGP2	NNP
cord-350836-1enteev7	393	2	orthologs	ortholog	NNS
cord-350836-1enteev7	393	3	are	be	VBP
cord-350836-1enteev7	393	4	also	also	RB
cord-350836-1enteev7	393	5	only	only	RB
cord-350836-1enteev7	393	6	found	find	VBN
cord-350836-1enteev7	393	7	in	in	IN
cord-350836-1enteev7	393	8	vertebrates	vertebrate	NNS
cord-350836-1enteev7	393	9	while	while	IN
cord-350836-1enteev7	393	10	the	the	DT
cord-350836-1enteev7	393	11	next	next	JJ
cord-350836-1enteev7	393	12	closest	close	JJS
cord-350836-1enteev7	393	13	related	related	JJ
cord-350836-1enteev7	393	14	family	family	NN
cord-350836-1enteev7	393	15	of	of	IN
cord-350836-1enteev7	393	16	proteins	protein	NNS
cord-350836-1enteev7	393	17	(	(	-LRB-
cord-350836-1enteev7	393	18	Dicer	dicer	NN
cord-350836-1enteev7	393	19	)	)	-RRB-
cord-350836-1enteev7	393	20	are	be	VBP
cord-350836-1enteev7	393	21	more	more	JJR
cord-350836-1enteev7	393	22	ancient	ancient	JJ
cord-350836-1enteev7	393	23	proteins	protein	NNS
cord-350836-1enteev7	393	24	.	.	.
cord-350836-1enteev7	394	1	It	-PRON-	PRP
cord-350836-1enteev7	394	2	has	have	VBZ
cord-350836-1enteev7	394	3	therefore	therefore	RB
cord-350836-1enteev7	394	4	been	be	VBN
cord-350836-1enteev7	394	5	proposed	propose	VBN
cord-350836-1enteev7	394	6	that	that	IN
cord-350836-1enteev7	394	7	the	the	DT
cord-350836-1enteev7	394	8	RIG	rig	NN
cord-350836-1enteev7	394	9	-	-	:
cord-350836-1enteev7	394	10	I	i	NN
cord-350836-1enteev7	394	11	helicase	helicase	NN
cord-350836-1enteev7	394	12	-	-	HYPH
cord-350836-1enteev7	394	13	DExD	DExD	NNS
cord-350836-1enteev7	394	14	/	/	SYM
cord-350836-1enteev7	394	15	H	h	NN
cord-350836-1enteev7	394	16	complex	complex	NN
cord-350836-1enteev7	394	17	may	may	MD
cord-350836-1enteev7	394	18	have	have	VB
cord-350836-1enteev7	394	19	been	be	VBN
cord-350836-1enteev7	394	20	duplicated	duplicate	VBN
cord-350836-1enteev7	394	21	from	from	IN
cord-350836-1enteev7	394	22	MDA5	MDA5	NNP
cord-350836-1enteev7	394	23	in	in	IN
cord-350836-1enteev7	394	24	the	the	DT
cord-350836-1enteev7	394	25	common	common	JJ
cord-350836-1enteev7	394	26	ancestor	ancestor	NN
cord-350836-1enteev7	394	27	of	of	IN
cord-350836-1enteev7	394	28	vertebrates	vertebrate	NNS
cord-350836-1enteev7	394	29	(	(	-LRB-
cord-350836-1enteev7	394	30	184	184	CD
cord-350836-1enteev7	394	31	)	)	-RRB-
cord-350836-1enteev7	394	32	.	.	.
cord-350836-1enteev7	395	1	The	the	DT
cord-350836-1enteev7	395	2	association	association	NN
cord-350836-1enteev7	395	3	of	of	IN
cord-350836-1enteev7	395	4	the	the	DT
cord-350836-1enteev7	395	5	two	two	CD
cord-350836-1enteev7	395	6	CARD	card	NN
cord-350836-1enteev7	395	7	domains	domain	NNS
cord-350836-1enteev7	395	8	appears	appear	VBZ
cord-350836-1enteev7	395	9	to	to	TO
cord-350836-1enteev7	395	10	have	have	VB
cord-350836-1enteev7	395	11	followed	follow	VBN
cord-350836-1enteev7	395	12	,	,	,
cord-350836-1enteev7	395	13	as	as	IN
cord-350836-1enteev7	395	14	individual	individual	JJ
cord-350836-1enteev7	395	15	CARD	card	NN
cord-350836-1enteev7	395	16	domains	domain	NNS
cord-350836-1enteev7	395	17	are	be	VBP
cord-350836-1enteev7	395	18	found	find	VBN
cord-350836-1enteev7	395	19	in	in	IN
cord-350836-1enteev7	395	20	a	a	DT
cord-350836-1enteev7	395	21	variety	variety	NN
cord-350836-1enteev7	395	22	of	of	IN
cord-350836-1enteev7	395	23	vertebrates	vertebrate	NNS
cord-350836-1enteev7	395	24	that	that	WDT
cord-350836-1enteev7	395	25	also	also	RB
cord-350836-1enteev7	395	26	encode	encode	VBP
cord-350836-1enteev7	395	27	caspases	caspase	NNS
cord-350836-1enteev7	395	28	(	(	-LRB-
cord-350836-1enteev7	395	29	344	344	CD
cord-350836-1enteev7	395	30	,	,	,
cord-350836-1enteev7	395	31	345	345	CD
cord-350836-1enteev7	395	32	)	)	-RRB-
cord-350836-1enteev7	395	33	,	,	,
cord-350836-1enteev7	395	34	but	but	CC
cord-350836-1enteev7	395	35	only	only	JJ
cord-350836-1enteev7	395	36	RIG	rig	NN
cord-350836-1enteev7	395	37	-	-	:
cord-350836-1enteev7	395	38	I	I	NNP
cord-350836-1enteev7	395	39	,	,	,
cord-350836-1enteev7	395	40	MDA5	MDA5	NNP
cord-350836-1enteev7	395	41	,	,	,
cord-350836-1enteev7	395	42	and	and	CC
cord-350836-1enteev7	395	43	certain	certain	JJ
cord-350836-1enteev7	395	44	members	member	NNS
cord-350836-1enteev7	395	45	of	of	IN
cord-350836-1enteev7	395	46	the	the	DT
cord-350836-1enteev7	395	47	Nacht	Nacht	NNP
cord-350836-1enteev7	395	48	family	family	NN
cord-350836-1enteev7	395	49	of	of	IN
cord-350836-1enteev7	395	50	NTPases	NTPases	NNP
cord-350836-1enteev7	395	51	(	(	-LRB-
cord-350836-1enteev7	395	52	346	346	CD
cord-350836-1enteev7	395	53	)	)	-RRB-
cord-350836-1enteev7	395	54	have	have	VB
cord-350836-1enteev7	395	55	two	two	CD
cord-350836-1enteev7	395	56	CARD	card	NN
cord-350836-1enteev7	395	57	domains	domain	NNS
cord-350836-1enteev7	395	58	.	.	.
cord-350836-1enteev7	396	1	Phylogenetic	phylogenetic	JJ
cord-350836-1enteev7	396	2	analysis	analysis	NN
cord-350836-1enteev7	396	3	has	have	VBZ
cord-350836-1enteev7	396	4	shown	show	VBN
cord-350836-1enteev7	396	5	that	that	IN
cord-350836-1enteev7	396	6	the	the	DT
cord-350836-1enteev7	396	7	helicase	helicase	NN
cord-350836-1enteev7	396	8	-	-	HYPH
cord-350836-1enteev7	396	9	DExD	DExD	NNS
cord-350836-1enteev7	396	10	/	/	SYM
cord-350836-1enteev7	396	11	H	h	NN
cord-350836-1enteev7	396	12	and	and	CC
cord-350836-1enteev7	396	13	CARD2	CARD2	NNS
cord-350836-1enteev7	396	14	have	have	VBP
cord-350836-1enteev7	396	15	strong	strong	JJ
cord-350836-1enteev7	396	16	co	co	JJ
cord-350836-1enteev7	396	17	-	-	JJ
cord-350836-1enteev7	396	18	evolution	evolution	JJ
cord-350836-1enteev7	396	19	history	history	NN
cord-350836-1enteev7	396	20	(	(	-LRB-
cord-350836-1enteev7	396	21	347	347	CD
cord-350836-1enteev7	396	22	,	,	,
cord-350836-1enteev7	396	23	348	348	CD
cord-350836-1enteev7	396	24	)	)	-RRB-
cord-350836-1enteev7	396	25	,	,	,
cord-350836-1enteev7	396	26	while	while	IN
cord-350836-1enteev7	396	27	CARD1	card1	NN
cord-350836-1enteev7	396	28	has	have	VBZ
cord-350836-1enteev7	396	29	evolved	evolve	VBN
cord-350836-1enteev7	396	30	more	more	RBR
cord-350836-1enteev7	396	31	independently	independently	RB
cord-350836-1enteev7	396	32	(	(	-LRB-
cord-350836-1enteev7	396	33	184	184	CD
cord-350836-1enteev7	396	34	)	)	-RRB-
cord-350836-1enteev7	396	35	.	.	.
cord-350836-1enteev7	397	1	CARD2	CARD2	NNP
cord-350836-1enteev7	397	2	appears	appear	VBZ
cord-350836-1enteev7	397	3	to	to	TO
cord-350836-1enteev7	397	4	have	have	VB
cord-350836-1enteev7	397	5	been	be	VBN
cord-350836-1enteev7	397	6	grafted	graft	VBN
cord-350836-1enteev7	397	7	onto	onto	IN
cord-350836-1enteev7	397	8	the	the	DT
cord-350836-1enteev7	397	9	RIG-	RIG-	NNP
cord-350836-1enteev7	398	1	I	-PRON-	PRP
cord-350836-1enteev7	398	2	helicase	helicase	NN
cord-350836-1enteev7	398	3	-	-	HYPH
cord-350836-1enteev7	398	4	DExD	DExD	NNS
cord-350836-1enteev7	398	5	/	/	SYM
cord-350836-1enteev7	398	6	H	h	NN
cord-350836-1enteev7	398	7	complex	complex	NN
cord-350836-1enteev7	398	8	first	first	RB
cord-350836-1enteev7	398	9	,	,	,
cord-350836-1enteev7	398	10	with	with	IN
cord-350836-1enteev7	398	11	the	the	DT
cord-350836-1enteev7	398	12	CARD2-MDA5	CARD2-MDA5	NNP
cord-350836-1enteev7	398	13	being	be	VBG
cord-350836-1enteev7	398	14	duplicated	duplicate	VBN
cord-350836-1enteev7	398	15	from	from	IN
cord-350836-1enteev7	398	16	this	this	DT
cord-350836-1enteev7	398	17	event	event	NN
cord-350836-1enteev7	398	18	.	.	.
cord-350836-1enteev7	399	1	Finally	finally	RB
cord-350836-1enteev7	399	2	,	,	,
cord-350836-1enteev7	399	3	CARD1	CARD1	NNP
cord-350836-1enteev7	399	4	was	be	VBD
cord-350836-1enteev7	399	5	grafted	graft	VBN
cord-350836-1enteev7	399	6	onto	onto	IN
cord-350836-1enteev7	399	7	the	the	DT
cord-350836-1enteev7	399	8	CARD2-helicase	CARD2-helicase	NNP
cord-350836-1enteev7	399	9	-	-	HYPH
cord-350836-1enteev7	399	10	DExD	DExD	NNS
cord-350836-1enteev7	399	11	/	/	SYM
cord-350836-1enteev7	399	12	H	h	NN
cord-350836-1enteev7	399	13	complex	complex	NN
cord-350836-1enteev7	399	14	in	in	IN
cord-350836-1enteev7	399	15	separate	separate	JJ
cord-350836-1enteev7	399	16	events	event	NNS
cord-350836-1enteev7	399	17	for	for	IN
cord-350836-1enteev7	399	18	RIG	rig	NN
cord-350836-1enteev7	399	19	-	-	:
cord-350836-1enteev7	399	20	I	I	NNP
cord-350836-1enteev7	399	21	and	and	CC
cord-350836-1enteev7	399	22	MDA5	MDA5	NNP
cord-350836-1enteev7	399	23	(	(	-LRB-
cord-350836-1enteev7	399	24	184	184	CD
cord-350836-1enteev7	399	25	)	)	-RRB-
cord-350836-1enteev7	399	26	.	.	.
cord-350836-1enteev7	400	1	In	in	IN
cord-350836-1enteev7	400	2	mammals	mammal	NNS
cord-350836-1enteev7	400	3	,	,	,
cord-350836-1enteev7	400	4	positive	positive	JJ
cord-350836-1enteev7	400	5	selection	selection	NN
cord-350836-1enteev7	400	6	can	can	MD
cord-350836-1enteev7	400	7	be	be	VB
cord-350836-1enteev7	400	8	seen	see	VBN
cord-350836-1enteev7	400	9	in	in	IN
cord-350836-1enteev7	400	10	the	the	DT
cord-350836-1enteev7	400	11	flexible	flexible	JJ
cord-350836-1enteev7	400	12	hinge	hinge	NN
cord-350836-1enteev7	400	13	region	region	NN
cord-350836-1enteev7	400	14	connecting	connect	VBG
cord-350836-1enteev7	400	15	the	the	DT
cord-350836-1enteev7	400	16	CARD	card	NN
cord-350836-1enteev7	400	17	domains	domain	NNS
cord-350836-1enteev7	400	18	to	to	IN
cord-350836-1enteev7	400	19	the	the	DT
cord-350836-1enteev7	400	20	helicase	helicase	NN
cord-350836-1enteev7	400	21	in	in	IN
cord-350836-1enteev7	400	22	RIG	rig	NN
cord-350836-1enteev7	400	23	-	-	:
cord-350836-1enteev7	400	24	I	I	NNP
cord-350836-1enteev7	400	25	and	and	CC
cord-350836-1enteev7	400	26	MDA5	MDA5	NNP
cord-350836-1enteev7	400	27	.	.	.
cord-350836-1enteev7	401	1	RIG	rig	NN
cord-350836-1enteev7	401	2	-	-	:
cord-350836-1enteev7	401	3	I	-PRON-	PRP
cord-350836-1enteev7	401	4	contains	contain	VBZ
cord-350836-1enteev7	401	5	an	an	DT
cord-350836-1enteev7	401	6	additional	additional	JJ
cord-350836-1enteev7	401	7	site	site	NN
cord-350836-1enteev7	401	8	of	of	IN
cord-350836-1enteev7	401	9	positive	positive	JJ
cord-350836-1enteev7	401	10	selection	selection	NN
cord-350836-1enteev7	401	11	within	within	IN
cord-350836-1enteev7	401	12	the	the	DT
cord-350836-1enteev7	401	13	Hel1	Hel1	NNP
cord-350836-1enteev7	401	14	structural	structural	JJ
cord-350836-1enteev7	401	15	motif	motif	NN
cord-350836-1enteev7	401	16	(	(	-LRB-
cord-350836-1enteev7	401	17	N421	n421	CD
cord-350836-1enteev7	401	18	)	)	-RRB-
cord-350836-1enteev7	401	19	,	,	,
cord-350836-1enteev7	401	20	while	while	IN
cord-350836-1enteev7	401	21	most	most	JJS
cord-350836-1enteev7	401	22	of	of	IN
cord-350836-1enteev7	401	23	the	the	DT
cord-350836-1enteev7	401	24	unique	unique	JJ
cord-350836-1enteev7	401	25	positive	positive	JJ
cord-350836-1enteev7	401	26	selection	selection	NN
cord-350836-1enteev7	401	27	sites	site	NNS
cord-350836-1enteev7	401	28	for	for	IN
cord-350836-1enteev7	401	29	MDA5	MDA5	NNP
cord-350836-1enteev7	401	30	are	be	VBP
cord-350836-1enteev7	401	31	in	in	IN
cord-350836-1enteev7	401	32	regions	region	NNS
cord-350836-1enteev7	401	33	specific	specific	JJ
cord-350836-1enteev7	401	34	to	to	IN
cord-350836-1enteev7	401	35	it	-PRON-	PRP
cord-350836-1enteev7	401	36	,	,	,
cord-350836-1enteev7	401	37	including	include	VBG
cord-350836-1enteev7	401	38	a	a	DT
cord-350836-1enteev7	401	39	29	29	CD
cord-350836-1enteev7	401	40	amino	amino	NN
cord-350836-1enteev7	401	41	acid	acid	NN
cord-350836-1enteev7	401	42	insertion	insertion	NN
cord-350836-1enteev7	401	43	in	in	IN
cord-350836-1enteev7	401	44	Hel2	Hel2	NNP
cord-350836-1enteev7	401	45	(	(	-LRB-
cord-350836-1enteev7	401	46	349	349	CD
cord-350836-1enteev7	401	47	)	)	-RRB-
cord-350836-1enteev7	401	48	.	.	.
cord-350836-1enteev7	402	1	While	while	IN
cord-350836-1enteev7	402	2	RIG	rig	NN
cord-350836-1enteev7	402	3	-	-	:
cord-350836-1enteev7	402	4	I	I	NNP
cord-350836-1enteev7	402	5	and	and	CC
cord-350836-1enteev7	402	6	MDA5	MDA5	NNP
cord-350836-1enteev7	402	7	may	may	MD
cord-350836-1enteev7	402	8	both	both	DT
cord-350836-1enteev7	402	9	originate	originate	VB
cord-350836-1enteev7	402	10	from	from	IN
cord-350836-1enteev7	402	11	common	common	JJ
cord-350836-1enteev7	402	12	ancestors	ancestor	NNS
cord-350836-1enteev7	402	13	of	of	IN
cord-350836-1enteev7	402	14	vertebrates	vertebrate	NNS
cord-350836-1enteev7	402	15	,	,	,
cord-350836-1enteev7	402	16	there	there	EX
cord-350836-1enteev7	402	17	is	be	VBZ
cord-350836-1enteev7	402	18	increasing	increase	VBG
cord-350836-1enteev7	402	19	evidence	evidence	NN
cord-350836-1enteev7	402	20	to	to	TO
cord-350836-1enteev7	402	21	suggest	suggest	VB
cord-350836-1enteev7	402	22	,	,	,
cord-350836-1enteev7	402	23	and	and	CC
cord-350836-1enteev7	402	24	related	relate	VBN
cord-350836-1enteev7	402	25	DExD	DExD	NNS
cord-350836-1enteev7	402	26	/	/	SYM
cord-350836-1enteev7	402	27	H	h	NN
cord-350836-1enteev7	402	28	-	-	HYPH
cord-350836-1enteev7	402	29	box	box	NN
cord-350836-1enteev7	402	30	helicases	helicase	NNS
cord-350836-1enteev7	402	31	are	be	VBP
cord-350836-1enteev7	402	32	shown	show	VBN
cord-350836-1enteev7	402	33	as	as	IN
cord-350836-1enteev7	402	34	a	a	DT
cord-350836-1enteev7	402	35	phylogenetic	phylogenetic	JJ
cord-350836-1enteev7	402	36	tree	tree	NN
cord-350836-1enteev7	402	37	,	,	,
cord-350836-1enteev7	402	38	along	along	IN
cord-350836-1enteev7	402	39	with	with	IN
cord-350836-1enteev7	402	40	their	-PRON-	PRP$
cord-350836-1enteev7	402	41	lowest	low	JJS
cord-350836-1enteev7	402	42	level	level	NN
cord-350836-1enteev7	402	43	of	of	IN
cord-350836-1enteev7	402	44	biological	biological	JJ
cord-350836-1enteev7	402	45	taxonomy	taxonomy	NN
cord-350836-1enteev7	402	46	that	that	WDT
cord-350836-1enteev7	402	47	these	these	DT
cord-350836-1enteev7	402	48	proteins	protein	NNS
cord-350836-1enteev7	402	49	are	be	VBP
cord-350836-1enteev7	402	50	found	find	VBN
cord-350836-1enteev7	402	51	in	in	IN
cord-350836-1enteev7	402	52	present	present	JJ
cord-350836-1enteev7	402	53	day	day	NN
cord-350836-1enteev7	402	54	.	.	.
cord-350836-1enteev7	403	1	In	in	IN
cord-350836-1enteev7	403	2	short	short	JJ
cord-350836-1enteev7	403	3	,	,	,
cord-350836-1enteev7	403	4	the	the	DT
cord-350836-1enteev7	403	5	precursor	precursor	NN
cord-350836-1enteev7	403	6	of	of	IN
cord-350836-1enteev7	403	7	the	the	DT
cord-350836-1enteev7	403	8	MDA5	MDA5	NNP
cord-350836-1enteev7	403	9	helicase	helicase	NN
cord-350836-1enteev7	403	10	-	-	:
cord-350836-1enteev7	403	11	CTD	CTD	NNP
cord-350836-1enteev7	403	12	likely	likely	RB
cord-350836-1enteev7	403	13	originated	originate	VBD
cord-350836-1enteev7	403	14	from	from	IN
cord-350836-1enteev7	403	15	a	a	DT
cord-350836-1enteev7	403	16	common	common	JJ
cord-350836-1enteev7	403	17	ancestor	ancestor	NN
cord-350836-1enteev7	403	18	with	with	IN
cord-350836-1enteev7	403	19	the	the	DT
cord-350836-1enteev7	403	20	precursor	precursor	NN
cord-350836-1enteev7	403	21	for	for	IN
cord-350836-1enteev7	403	22	LGP2	LGP2	NNP
cord-350836-1enteev7	403	23	,	,	,
cord-350836-1enteev7	403	24	which	which	WDT
cord-350836-1enteev7	403	25	was	be	VBD
cord-350836-1enteev7	403	26	then	then	RB
cord-350836-1enteev7	403	27	duplicated	duplicate	VBN
cord-350836-1enteev7	403	28	to	to	TO
cord-350836-1enteev7	403	29	create	create	VB
cord-350836-1enteev7	403	30	the	the	DT
cord-350836-1enteev7	403	31	helicase	helicase	NN
cord-350836-1enteev7	403	32	-	-	HYPH
cord-350836-1enteev7	403	33	CTD	CTD	NNP
cord-350836-1enteev7	403	34	precursor	precursor	NN
cord-350836-1enteev7	403	35	of	of	IN
cord-350836-1enteev7	403	36	RIG	rig	NN
cord-350836-1enteev7	403	37	-	-	:
cord-350836-1enteev7	403	38	I	-PRON-	PRP
cord-350836-1enteev7	403	39	in	in	IN
cord-350836-1enteev7	403	40	the	the	DT
cord-350836-1enteev7	403	41	common	common	JJ
cord-350836-1enteev7	403	42	ancestor	ancestor	NN
cord-350836-1enteev7	403	43	of	of	IN
cord-350836-1enteev7	403	44	vertebrates	vertebrate	NNS
cord-350836-1enteev7	403	45	.	.	.
cord-350836-1enteev7	404	1	CARD2	CARD2	NNP
cord-350836-1enteev7	404	2	was	be	VBD
cord-350836-1enteev7	404	3	then	then	RB
cord-350836-1enteev7	404	4	grafted	graft	VBN
cord-350836-1enteev7	404	5	onto	onto	IN
cord-350836-1enteev7	404	6	the	the	DT
cord-350836-1enteev7	404	7	helicase	helicase	NN
cord-350836-1enteev7	404	8	-	-	HYPH
cord-350836-1enteev7	404	9	CTD	CTD	NNP
cord-350836-1enteev7	404	10	protein	protein	NN
cord-350836-1enteev7	404	11	,	,	,
cord-350836-1enteev7	404	12	and	and	CC
cord-350836-1enteev7	404	13	this	this	DT
cord-350836-1enteev7	404	14	protein	protein	NN
cord-350836-1enteev7	404	15	was	be	VBD
cord-350836-1enteev7	404	16	duplicated	duplicate	VBN
cord-350836-1enteev7	404	17	to	to	TO
cord-350836-1enteev7	404	18	create	create	VB
cord-350836-1enteev7	404	19	the	the	DT
cord-350836-1enteev7	404	20	CARD2-helicase	CARD2-helicase	NNP
cord-350836-1enteev7	404	21	-	-	HYPH
cord-350836-1enteev7	404	22	CTD	CTD	NNP
cord-350836-1enteev7	404	23	precursor	precursor	NN
cord-350836-1enteev7	404	24	of	of	IN
cord-350836-1enteev7	404	25	MDA5	MDA5	NNP
cord-350836-1enteev7	404	26	.	.	.
cord-350836-1enteev7	405	1	Finally	finally	RB
cord-350836-1enteev7	405	2	,	,	,
cord-350836-1enteev7	405	3	CARD1	CARD1	NNP
cord-350836-1enteev7	405	4	was	be	VBD
cord-350836-1enteev7	405	5	grafted	graft	VBN
cord-350836-1enteev7	405	6	onto	onto	IN
cord-350836-1enteev7	405	7	these	these	DT
cord-350836-1enteev7	405	8	proteins	protein	NNS
cord-350836-1enteev7	405	9	in	in	IN
cord-350836-1enteev7	405	10	separate	separate	JJ
cord-350836-1enteev7	405	11	events	event	NNS
cord-350836-1enteev7	405	12	,	,	,
cord-350836-1enteev7	405	13	forming	form	VBG
cord-350836-1enteev7	405	14	the	the	DT
cord-350836-1enteev7	405	15	modern	modern	JJ
cord-350836-1enteev7	405	16	-	-	HYPH
cord-350836-1enteev7	405	17	day	day	NN
cord-350836-1enteev7	405	18	RIG	rig	NN
cord-350836-1enteev7	405	19	-	-	:
cord-350836-1enteev7	405	20	I	I	NNP
cord-350836-1enteev7	405	21	and	and	CC
cord-350836-1enteev7	405	22	MDA5	MDA5	NNP
cord-350836-1enteev7	405	23	.	.	.
cord-350836-1enteev7	406	1	that	that	IN
cord-350836-1enteev7	406	2	proteins	protein	NNS
cord-350836-1enteev7	406	3	with	with	IN
cord-350836-1enteev7	406	4	similar	similar	JJ
cord-350836-1enteev7	406	5	functions	function	NNS
cord-350836-1enteev7	406	6	may	may	MD
cord-350836-1enteev7	406	7	have	have	VB
cord-350836-1enteev7	406	8	evolved	evolve	VBN
cord-350836-1enteev7	406	9	separately	separately	RB
cord-350836-1enteev7	406	10	in	in	IN
cord-350836-1enteev7	406	11	other	other	JJ
cord-350836-1enteev7	406	12	species	specie	NNS
cord-350836-1enteev7	406	13	from	from	IN
cord-350836-1enteev7	406	14	ancient	ancient	JJ
cord-350836-1enteev7	406	15	helicase	helicase	NN
cord-350836-1enteev7	406	16	-	-	HYPH
cord-350836-1enteev7	406	17	DExD	DExD	NNS
cord-350836-1enteev7	406	18	/	/	SYM
cord-350836-1enteev7	406	19	H	h	NN
cord-350836-1enteev7	406	20	proteins	protein	NNS
cord-350836-1enteev7	406	21	,	,	,
cord-350836-1enteev7	406	22	implicating	implicate	VBG
cord-350836-1enteev7	406	23	RNA	rna	NN
cord-350836-1enteev7	406	24	-	-	HYPH
cord-350836-1enteev7	406	25	mediated	mediate	VBN
cord-350836-1enteev7	406	26	defense	defense	NN
cord-350836-1enteev7	406	27	responses	response	NNS
cord-350836-1enteev7	406	28	as	as	IN
cord-350836-1enteev7	406	29	a	a	DT
cord-350836-1enteev7	406	30	potentially	potentially	RB
cord-350836-1enteev7	406	31	universal	universal	JJ
cord-350836-1enteev7	406	32	biological	biological	JJ
cord-350836-1enteev7	406	33	function	function	NN
cord-350836-1enteev7	406	34	.	.	.
cord-350836-1enteev7	407	1	A	a	DT
cord-350836-1enteev7	407	2	RIG	rig	NN
cord-350836-1enteev7	407	3	-	-	:
cord-350836-1enteev7	407	4	I	-PRON-	PRP
cord-350836-1enteev7	407	5	homolog	homolog	NN
cord-350836-1enteev7	407	6	has	have	VBZ
cord-350836-1enteev7	407	7	recently	recently	RB
cord-350836-1enteev7	407	8	been	be	VBN
cord-350836-1enteev7	407	9	found	find	VBN
cord-350836-1enteev7	407	10	in	in	IN
cord-350836-1enteev7	407	11	a	a	DT
cord-350836-1enteev7	407	12	planarian	planarian	NN
cord-350836-1enteev7	407	13	that	that	WDT
cord-350836-1enteev7	407	14	is	be	VBZ
cord-350836-1enteev7	407	15	able	able	JJ
cord-350836-1enteev7	407	16	to	to	TO
cord-350836-1enteev7	407	17	activate	activate	VB
cord-350836-1enteev7	407	18	downstream	downstream	JJ
cord-350836-1enteev7	407	19	inflammatory	inflammatory	JJ
cord-350836-1enteev7	407	20	genes	gene	NNS
cord-350836-1enteev7	407	21	in	in	IN
cord-350836-1enteev7	407	22	the	the	DT
cord-350836-1enteev7	407	23	absence	absence	NN
cord-350836-1enteev7	407	24	of	of	IN
cord-350836-1enteev7	407	25	the	the	DT
cord-350836-1enteev7	407	26	traditional	traditional	JJ
cord-350836-1enteev7	407	27	CARD	card	NN
cord-350836-1enteev7	407	28	domains	domain	NNS
cord-350836-1enteev7	407	29	(	(	-LRB-
cord-350836-1enteev7	407	30	350	350	CD
cord-350836-1enteev7	407	31	)	)	-RRB-
cord-350836-1enteev7	407	32	,	,	,
cord-350836-1enteev7	407	33	and	and	CC
cord-350836-1enteev7	407	34	a	a	DT
cord-350836-1enteev7	407	35	similar	similar	JJ
cord-350836-1enteev7	407	36	homolog	homolog	NN
cord-350836-1enteev7	407	37	in	in	IN
cord-350836-1enteev7	407	38	Caenorhabditis	Caenorhabditis	NNP
cord-350836-1enteev7	407	39	elegans	elegan	NNS
cord-350836-1enteev7	407	40	has	have	VBZ
cord-350836-1enteev7	407	41	been	be	VBN
cord-350836-1enteev7	407	42	proposed	propose	VBN
cord-350836-1enteev7	407	43	to	to	TO
cord-350836-1enteev7	407	44	mediate	mediate	VB
cord-350836-1enteev7	407	45	anti	anti	JJ
cord-350836-1enteev7	407	46	-	-	JJ
cord-350836-1enteev7	407	47	viral	viral	JJ
cord-350836-1enteev7	407	48	RNAi	RNAi	NNS
cord-350836-1enteev7	407	49	by	by	IN
cord-350836-1enteev7	407	50	complexing	complexe	VBG
cord-350836-1enteev7	407	51	with	with	IN
cord-350836-1enteev7	407	52	Dicer	Dicer	NNP
cord-350836-1enteev7	407	53	and	and	CC
cord-350836-1enteev7	407	54	catalyzing	catalyze	VBG
cord-350836-1enteev7	407	55	their	-PRON-	PRP$
cord-350836-1enteev7	407	56	translocation	translocation	NN
cord-350836-1enteev7	407	57	on	on	IN
cord-350836-1enteev7	407	58	the	the	DT
cord-350836-1enteev7	407	59	viral	viral	JJ
cord-350836-1enteev7	407	60	genome	genome	NN
cord-350836-1enteev7	407	61	(	(	-LRB-
cord-350836-1enteev7	407	62	351	351	CD
cord-350836-1enteev7	407	63	)	)	-RRB-
cord-350836-1enteev7	407	64	.	.	.
cord-350836-1enteev7	408	1	Additionally	additionally	RB
cord-350836-1enteev7	408	2	,	,	,
cord-350836-1enteev7	408	3	insects	insect	NNS
cord-350836-1enteev7	408	4	have	have	VBP
cord-350836-1enteev7	408	5	been	be	VBN
cord-350836-1enteev7	408	6	found	find	VBN
cord-350836-1enteev7	408	7	to	to	TO
cord-350836-1enteev7	408	8	primarily	primarily	RB
cord-350836-1enteev7	408	9	respond	respond	VB
cord-350836-1enteev7	408	10	to	to	IN
cord-350836-1enteev7	408	11	RNA	RNA	NNP
cord-350836-1enteev7	408	12	viruses	virus	NNS
cord-350836-1enteev7	408	13	by	by	IN
cord-350836-1enteev7	408	14	RNAi	RNAi	NNS
cord-350836-1enteev7	408	15	mediated	mediate	VBN
cord-350836-1enteev7	408	16	by	by	IN
cord-350836-1enteev7	408	17	Dicer	Dicer	NNP
cord-350836-1enteev7	408	18	proteins	protein	NNS
cord-350836-1enteev7	408	19	(	(	-LRB-
cord-350836-1enteev7	408	20	352	352	CD
cord-350836-1enteev7	408	21	)	)	-RRB-
cord-350836-1enteev7	408	22	.	.	.
cord-350836-1enteev7	409	1	Dicer	Dicer	NNP
cord-350836-1enteev7	409	2	may	may	MD
cord-350836-1enteev7	409	3	potentially	potentially	RB
cord-350836-1enteev7	409	4	mediate	mediate	VB
cord-350836-1enteev7	409	5	dsRNA	dsrna	RB
cord-350836-1enteev7	409	6	-	-	HYPH
cord-350836-1enteev7	409	7	activated	activate	VBN
cord-350836-1enteev7	409	8	anti	anti	JJ
cord-350836-1enteev7	409	9	-	-	JJ
cord-350836-1enteev7	409	10	viral	viral	JJ
cord-350836-1enteev7	409	11	signaling	signal	VBG
cord-350836-1enteev7	409	12	pathways	pathway	NNS
cord-350836-1enteev7	409	13	that	that	WDT
cord-350836-1enteev7	409	14	is	be	VBZ
cord-350836-1enteev7	409	15	independent	independent	JJ
cord-350836-1enteev7	409	16	of	of	IN
cord-350836-1enteev7	409	17	RNAi	RNAi	NNP
cord-350836-1enteev7	409	18	pathways	pathway	NNS
cord-350836-1enteev7	409	19	,	,	,
cord-350836-1enteev7	409	20	as	as	IN
cord-350836-1enteev7	409	21	has	have	VBZ
cord-350836-1enteev7	409	22	been	be	VBN
cord-350836-1enteev7	409	23	found	find	VBN
cord-350836-1enteev7	409	24	to	to	TO
cord-350836-1enteev7	409	25	be	be	VB
cord-350836-1enteev7	409	26	the	the	DT
cord-350836-1enteev7	409	27	case	case	NN
cord-350836-1enteev7	409	28	for	for	IN
cord-350836-1enteev7	409	29	the	the	DT
cord-350836-1enteev7	409	30	expanded	expand	VBN
cord-350836-1enteev7	409	31	CAG	CAG	NNP
cord-350836-1enteev7	409	32	-	-	HYPH
cord-350836-1enteev7	409	33	repeat	repeat	NNP
cord-350836-1enteev7	409	34	dsRNA	dsRNA	.
cord-350836-1enteev7	410	1	(	(	-LRB-
cord-350836-1enteev7	410	2	353	353	CD
cord-350836-1enteev7	410	3	)	)	-RRB-
cord-350836-1enteev7	410	4	.	.	.
cord-350836-1enteev7	411	1	Pattern	pattern	NN
cord-350836-1enteev7	411	2	recognition	recognition	NN
cord-350836-1enteev7	411	3	receptors	receptor	NNS
cord-350836-1enteev7	411	4	(	(	-LRB-
cord-350836-1enteev7	411	5	PRRs	PRRs	NNP
cord-350836-1enteev7	411	6	)	)	-RRB-
cord-350836-1enteev7	411	7	that	that	WDT
cord-350836-1enteev7	411	8	respond	respond	VBP
cord-350836-1enteev7	411	9	to	to	IN
cord-350836-1enteev7	411	10	viral	viral	JJ
cord-350836-1enteev7	411	11	RNA	RNA	NNP
cord-350836-1enteev7	411	12	have	have	VBP
cord-350836-1enteev7	411	13	not	not	RB
cord-350836-1enteev7	411	14	yet	yet	RB
cord-350836-1enteev7	411	15	been	be	VBN
cord-350836-1enteev7	411	16	found	find	VBN
cord-350836-1enteev7	411	17	outside	outside	RB
cord-350836-1enteev7	411	18	of	of	IN
cord-350836-1enteev7	411	19	the	the	DT
cord-350836-1enteev7	411	20	animal	animal	NN
cord-350836-1enteev7	411	21	kingdom	kingdom	NN
cord-350836-1enteev7	411	22	,	,	,
cord-350836-1enteev7	411	23	as	as	IN
cord-350836-1enteev7	411	24	RLRlike	rlrlike	JJ
cord-350836-1enteev7	411	25	proteins	protein	NNS
cord-350836-1enteev7	411	26	in	in	IN
cord-350836-1enteev7	411	27	prokaryotes	prokaryote	NNS
cord-350836-1enteev7	411	28	do	do	VBP
cord-350836-1enteev7	411	29	not	not	RB
cord-350836-1enteev7	411	30	have	have	VB
cord-350836-1enteev7	411	31	CARD	card	NN
cord-350836-1enteev7	411	32	domains	domain	NNS
cord-350836-1enteev7	411	33	and	and	CC
cord-350836-1enteev7	411	34	the	the	DT
cord-350836-1enteev7	411	35	PRRs	prr	NNS
cord-350836-1enteev7	411	36	in	in	IN
cord-350836-1enteev7	411	37	plants	plant	NNS
cord-350836-1enteev7	411	38	found	find	VBN
cord-350836-1enteev7	411	39	so	so	RB
cord-350836-1enteev7	411	40	far	far	RB
cord-350836-1enteev7	411	41	are	be	VBP
cord-350836-1enteev7	411	42	surface	surface	NN
cord-350836-1enteev7	411	43	-	-	HYPH
cord-350836-1enteev7	411	44	receptor	receptor	NN
cord-350836-1enteev7	411	45	kinases	kinase	NNS
cord-350836-1enteev7	411	46	that	that	WDT
cord-350836-1enteev7	411	47	respond	respond	VBP
cord-350836-1enteev7	411	48	to	to	IN
cord-350836-1enteev7	411	49	external	external	JJ
cord-350836-1enteev7	411	50	molecular	molecular	JJ
cord-350836-1enteev7	411	51	elements	element	NNS
cord-350836-1enteev7	411	52	of	of	IN
cord-350836-1enteev7	411	53	bacteria	bacteria	NNS
cord-350836-1enteev7	411	54	(	(	-LRB-
cord-350836-1enteev7	411	55	354	354	CD
cord-350836-1enteev7	411	56	)	)	-RRB-
cord-350836-1enteev7	411	57	[	[	-LRB-
cord-350836-1enteev7	411	58	similar	similar	JJ
cord-350836-1enteev7	411	59	to	to	IN
cord-350836-1enteev7	411	60	the	the	DT
cord-350836-1enteev7	411	61	mammalian	mammalian	JJ
cord-350836-1enteev7	411	62	toll	toll	NN
cord-350836-1enteev7	411	63	-	-	HYPH
cord-350836-1enteev7	411	64	like	like	JJ
cord-350836-1enteev7	411	65	receptors	receptor	NNS
cord-350836-1enteev7	411	66	(	(	-LRB-
cord-350836-1enteev7	411	67	TLRs	TLRs	NNP
cord-350836-1enteev7	411	68	)	)	-RRB-
cord-350836-1enteev7	411	69	]	]	-RRB-
cord-350836-1enteev7	411	70	.	.	.
cord-350836-1enteev7	412	1	However	however	RB
cord-350836-1enteev7	412	2	,	,	,
cord-350836-1enteev7	412	3	RNA	RNA	NNP
cord-350836-1enteev7	412	4	silencing	silencing	NN
cord-350836-1enteev7	412	5	has	have	VBZ
cord-350836-1enteev7	412	6	been	be	VBN
cord-350836-1enteev7	412	7	demonstrated	demonstrate	VBN
cord-350836-1enteev7	412	8	to	to	TO
cord-350836-1enteev7	412	9	be	be	VB
cord-350836-1enteev7	412	10	an	an	DT
cord-350836-1enteev7	412	11	important	important	JJ
cord-350836-1enteev7	412	12	anti	anti	JJ
cord-350836-1enteev7	412	13	-	-	JJ
cord-350836-1enteev7	412	14	viral	viral	JJ
cord-350836-1enteev7	412	15	strategy	strategy	NN
cord-350836-1enteev7	412	16	in	in	IN
cord-350836-1enteev7	412	17	plants	plant	NNS
cord-350836-1enteev7	412	18	(	(	-LRB-
cord-350836-1enteev7	412	19	354	354	CD
cord-350836-1enteev7	412	20	,	,	,
cord-350836-1enteev7	412	21	355	355	CD
cord-350836-1enteev7	412	22	)	)	-RRB-
cord-350836-1enteev7	412	23	and	and	CC
cord-350836-1enteev7	412	24	certain	certain	JJ
cord-350836-1enteev7	412	25	Arabidopsis	Arabidopsis	NNP
cord-350836-1enteev7	412	26	mutants	mutant	NNS
cord-350836-1enteev7	412	27	appear	appear	VBP
cord-350836-1enteev7	412	28	to	to	TO
cord-350836-1enteev7	412	29	be	be	VB
cord-350836-1enteev7	412	30	more	more	RBR
cord-350836-1enteev7	412	31	susceptible	susceptible	JJ
cord-350836-1enteev7	412	32	to	to	IN
cord-350836-1enteev7	412	33	infection	infection	NN
cord-350836-1enteev7	412	34	by	by	IN
cord-350836-1enteev7	412	35	RNA	RNA	NNP
cord-350836-1enteev7	412	36	viruses	virus	NNS
cord-350836-1enteev7	412	37	(	(	-LRB-
cord-350836-1enteev7	412	38	356	356	CD
cord-350836-1enteev7	412	39	)	)	-RRB-
cord-350836-1enteev7	412	40	.	.	.
cord-350836-1enteev7	413	1	RIG	rig	NN
cord-350836-1enteev7	413	2	-	-	:
cord-350836-1enteev7	413	3	I	i	NN
cord-350836-1enteev7	413	4	(	(	-LRB-
cord-350836-1enteev7	413	5	357	357	CD
cord-350836-1enteev7	413	6	)	)	-RRB-
cord-350836-1enteev7	413	7	and	and	CC
cord-350836-1enteev7	413	8	MDA5	MDA5	NNP
cord-350836-1enteev7	413	9	(	(	-LRB-
cord-350836-1enteev7	413	10	357	357	CD
cord-350836-1enteev7	413	11	,	,	,
cord-350836-1enteev7	413	12	358	358	CD
cord-350836-1enteev7	413	13	)	)	-RRB-
cord-350836-1enteev7	413	14	are	be	VBP
cord-350836-1enteev7	413	15	known	know	VBN
cord-350836-1enteev7	413	16	to	to	TO
cord-350836-1enteev7	413	17	influence	influence	VB
cord-350836-1enteev7	413	18	antiviral	antiviral	JJ
cord-350836-1enteev7	413	19	signaling	signal	VBG
cord-350836-1enteev7	413	20	in	in	IN
cord-350836-1enteev7	413	21	zebrafish	zebrafish	NN
cord-350836-1enteev7	413	22	(	(	-LRB-
cord-350836-1enteev7	413	23	Danio	Danio	NNP
cord-350836-1enteev7	413	24	rerio	rerio	NNP
cord-350836-1enteev7	413	25	)	)	-RRB-
cord-350836-1enteev7	413	26	and	and	CC
cord-350836-1enteev7	413	27	other	other	JJ
cord-350836-1enteev7	413	28	fish	fish	NN
cord-350836-1enteev7	413	29	species	specie	NNS
cord-350836-1enteev7	413	30	(	(	-LRB-
cord-350836-1enteev7	413	31	357	357	CD
cord-350836-1enteev7	413	32	,	,	,
cord-350836-1enteev7	413	33	(	(	-LRB-
cord-350836-1enteev7	413	34	359	359	CD
cord-350836-1enteev7	413	35	)	)	-RRB-
cord-350836-1enteev7	413	36	(	(	-LRB-
cord-350836-1enteev7	413	37	360	360	CD
cord-350836-1enteev7	413	38	)	)	-RRB-
cord-350836-1enteev7	413	39	(	(	-LRB-
cord-350836-1enteev7	413	40	361	361	CD
cord-350836-1enteev7	413	41	)	)	-RRB-
cord-350836-1enteev7	413	42	through	through	IN
cord-350836-1enteev7	413	43	the	the	DT
cord-350836-1enteev7	413	44	canonical	canonical	JJ
cord-350836-1enteev7	413	45	MAVS	MAVS	NNPS
cord-350836-1enteev7	413	46	signaling	signal	VBG
cord-350836-1enteev7	413	47	pathway	pathway	NN
cord-350836-1enteev7	413	48	.	.	.
cord-350836-1enteev7	414	1	Fish	Fish	NNP
cord-350836-1enteev7	414	2	RIG	rig	NN
cord-350836-1enteev7	414	3	-	-	:
cord-350836-1enteev7	414	4	I	-PRON-	PRP
cord-350836-1enteev7	414	5	like	like	IN
cord-350836-1enteev7	414	6	receptors	receptor	NNS
cord-350836-1enteev7	414	7	(	(	-LRB-
cord-350836-1enteev7	414	8	RLRs	rlr	NNS
cord-350836-1enteev7	414	9	)	)	-RRB-
cord-350836-1enteev7	414	10	have	have	VBP
cord-350836-1enteev7	414	11	been	be	VBN
cord-350836-1enteev7	414	12	shown	show	VBN
cord-350836-1enteev7	414	13	to	to	TO
cord-350836-1enteev7	414	14	be	be	VB
cord-350836-1enteev7	414	15	regulated	regulate	VBN
cord-350836-1enteev7	414	16	by	by	IN
cord-350836-1enteev7	414	17	the	the	DT
cord-350836-1enteev7	414	18	expression	expression	NN
cord-350836-1enteev7	414	19	of	of	IN
cord-350836-1enteev7	414	20	alternate	alternate	JJ
cord-350836-1enteev7	414	21	splicing	splicing	NN
cord-350836-1enteev7	414	22	isoforms	isoform	NNS
cord-350836-1enteev7	414	23	(	(	-LRB-
cord-350836-1enteev7	414	24	358	358	CD
cord-350836-1enteev7	414	25	,	,	,
cord-350836-1enteev7	414	26	362	362	CD
cord-350836-1enteev7	414	27	)	)	-RRB-
cord-350836-1enteev7	414	28	,	,	,
cord-350836-1enteev7	414	29	which	which	WDT
cord-350836-1enteev7	414	30	have	have	VBP
cord-350836-1enteev7	414	31	also	also	RB
cord-350836-1enteev7	414	32	been	be	VBN
cord-350836-1enteev7	414	33	found	find	VBN
cord-350836-1enteev7	414	34	to	to	TO
cord-350836-1enteev7	414	35	occur	occur	VB
cord-350836-1enteev7	414	36	with	with	IN
cord-350836-1enteev7	414	37	a	a	DT
cord-350836-1enteev7	414	38	dominant	dominant	JJ
cord-350836-1enteev7	414	39	-	-	HYPH
cord-350836-1enteev7	414	40	negative	negative	JJ
cord-350836-1enteev7	414	41	splice	splice	NN
cord-350836-1enteev7	414	42	variant	variant	NN
cord-350836-1enteev7	414	43	of	of	IN
cord-350836-1enteev7	414	44	the	the	DT
cord-350836-1enteev7	414	45	human	human	JJ
cord-350836-1enteev7	414	46	RIG	rig	NN
cord-350836-1enteev7	414	47	-	-	:
cord-350836-1enteev7	414	48	I	i	NN
cord-350836-1enteev7	414	49	(	(	-LRB-
cord-350836-1enteev7	414	50	363	363	CD
cord-350836-1enteev7	414	51	)	)	-RRB-
cord-350836-1enteev7	414	52	.	.	.
cord-350836-1enteev7	415	1	RIG	rig	NN
cord-350836-1enteev7	415	2	-	-	:
cord-350836-1enteev7	415	3	I	I	NNP
cord-350836-1enteev7	415	4	and	and	CC
cord-350836-1enteev7	415	5	MDA5	MDA5	NNP
cord-350836-1enteev7	415	6	have	have	VBP
cord-350836-1enteev7	415	7	also	also	RB
cord-350836-1enteev7	415	8	been	be	VBN
cord-350836-1enteev7	415	9	found	find	VBN
cord-350836-1enteev7	415	10	to	to	TO
cord-350836-1enteev7	415	11	participate	participate	VB
cord-350836-1enteev7	415	12	in	in	IN
cord-350836-1enteev7	415	13	anti	anti	JJ
cord-350836-1enteev7	415	14	-	-	JJ
cord-350836-1enteev7	415	15	viral	viral	JJ
cord-350836-1enteev7	415	16	signaling	signaling	NN
cord-350836-1enteev7	415	17	in	in	IN
cord-350836-1enteev7	415	18	ducks	duck	NNS
cord-350836-1enteev7	415	19	(	(	-LRB-
cord-350836-1enteev7	415	20	364	364	CD
cord-350836-1enteev7	415	21	)	)	-RRB-
cord-350836-1enteev7	416	1	(	(	-LRB-
cord-350836-1enteev7	416	2	365	365	CD
cord-350836-1enteev7	416	3	)	)	-RRB-
cord-350836-1enteev7	417	1	(	(	-LRB-
cord-350836-1enteev7	417	2	366	366	CD
cord-350836-1enteev7	417	3	)	)	-RRB-
cord-350836-1enteev7	417	4	(	(	-LRB-
cord-350836-1enteev7	417	5	367	367	CD
cord-350836-1enteev7	417	6	)	)	-RRB-
cord-350836-1enteev7	417	7	and	and	CC
cord-350836-1enteev7	417	8	geese	goose	NNS
cord-350836-1enteev7	417	9	(	(	-LRB-
cord-350836-1enteev7	417	10	340	340	CD
cord-350836-1enteev7	417	11	,	,	,
cord-350836-1enteev7	417	12	368	368	CD
cord-350836-1enteev7	417	13	,	,	,
cord-350836-1enteev7	417	14	369	369	CD
cord-350836-1enteev7	417	15	)	)	-RRB-
cord-350836-1enteev7	417	16	,	,	,
cord-350836-1enteev7	417	17	and	and	CC
cord-350836-1enteev7	417	18	MDA5	MDA5	NNP
cord-350836-1enteev7	417	19	alone	alone	RB
cord-350836-1enteev7	417	20	in	in	IN
cord-350836-1enteev7	417	21	chickens	chicken	NNS
cord-350836-1enteev7	417	22	(	(	-LRB-
cord-350836-1enteev7	417	23	370	370	CD
cord-350836-1enteev7	417	24	)	)	-RRB-
cord-350836-1enteev7	417	25	(	(	-LRB-
cord-350836-1enteev7	417	26	371	371	CD
cord-350836-1enteev7	417	27	)	)	-RRB-
cord-350836-1enteev7	417	28	(	(	-LRB-
cord-350836-1enteev7	417	29	372	372	CD
cord-350836-1enteev7	417	30	)	)	-RRB-
cord-350836-1enteev7	417	31	and	and	CC
cord-350836-1enteev7	417	32	other	other	JJ
cord-350836-1enteev7	417	33	birds	bird	NNS
cord-350836-1enteev7	417	34	(	(	-LRB-
cord-350836-1enteev7	417	35	373	373	CD
cord-350836-1enteev7	417	36	)	)	-RRB-
cord-350836-1enteev7	417	37	.	.	.
cord-350836-1enteev7	418	1	The	the	DT
cord-350836-1enteev7	418	2	observation	observation	NN
cord-350836-1enteev7	418	3	across	across	IN
cord-350836-1enteev7	418	4	species	specie	NNS
cord-350836-1enteev7	418	5	of	of	IN
cord-350836-1enteev7	418	6	RLR	RLR	NNP
cord-350836-1enteev7	418	7	's	's	POS
cord-350836-1enteev7	418	8	performing	perform	VBG
cord-350836-1enteev7	418	9	compensatory	compensatory	JJ
cord-350836-1enteev7	418	10	mechanisms	mechanism	NNS
cord-350836-1enteev7	418	11	when	when	WRB
cord-350836-1enteev7	418	12	a	a	DT
cord-350836-1enteev7	418	13	function	function	NN
cord-350836-1enteev7	418	14	or	or	CC
cord-350836-1enteev7	418	15	a	a	DT
cord-350836-1enteev7	418	16	pathway	pathway	NN
cord-350836-1enteev7	418	17	protein	protein	NN
cord-350836-1enteev7	418	18	is	be	VBZ
cord-350836-1enteev7	418	19	absent	absent	JJ
cord-350836-1enteev7	418	20	is	be	VBZ
cord-350836-1enteev7	418	21	reiterated	reiterate	VBN
cord-350836-1enteev7	418	22	in	in	IN
cord-350836-1enteev7	418	23	birds	bird	NNS
cord-350836-1enteev7	418	24	,	,	,
cord-350836-1enteev7	418	25	as	as	IN
cord-350836-1enteev7	418	26	MDA5	MDA5	NNP
cord-350836-1enteev7	418	27	has	have	VBZ
cord-350836-1enteev7	418	28	been	be	VBN
cord-350836-1enteev7	418	29	found	find	VBN
cord-350836-1enteev7	418	30	to	to	TO
cord-350836-1enteev7	418	31	sense	sense	VB
cord-350836-1enteev7	418	32	short	short	JJ
cord-350836-1enteev7	418	33	and	and	CC
cord-350836-1enteev7	418	34	long	long	JJ
cord-350836-1enteev7	418	35	dsRNA	dsrna	NN
cord-350836-1enteev7	419	1	in	in	IN
cord-350836-1enteev7	419	2	chickens	chicken	NNS
cord-350836-1enteev7	419	3	(	(	-LRB-
cord-350836-1enteev7	419	4	372	372	CD
cord-350836-1enteev7	419	5	)	)	-RRB-
cord-350836-1enteev7	419	6	and	and	CC
cord-350836-1enteev7	419	7	in	in	IN
cord-350836-1enteev7	419	8	the	the	DT
cord-350836-1enteev7	419	9	Chinese	chinese	JJ
cord-350836-1enteev7	419	10	shrew	shrew	NN
cord-350836-1enteev7	419	11	(	(	-LRB-
cord-350836-1enteev7	419	12	374	374	CD
cord-350836-1enteev7	419	13	)	)	-RRB-
cord-350836-1enteev7	419	14	,	,	,
cord-350836-1enteev7	419	15	both	both	DT
cord-350836-1enteev7	419	16	of	of	IN
cord-350836-1enteev7	419	17	which	which	WDT
cord-350836-1enteev7	419	18	lack	lack	VBP
cord-350836-1enteev7	420	1	RIG	rig	NN
cord-350836-1enteev7	420	2	-	-	HYPH
cord-350836-1enteev7	420	3	I.	i.	NN
cord-350836-1enteev7	420	4	Additionally	additionally	RB
cord-350836-1enteev7	420	5	,	,	,
cord-350836-1enteev7	420	6	TRIM25	TRIM25	NNP
cord-350836-1enteev7	420	7	activates	activate	VBZ
cord-350836-1enteev7	420	8	RIG	rig	NN
cord-350836-1enteev7	420	9	-	-	:
cord-350836-1enteev7	420	10	I	-PRON-	PRP
cord-350836-1enteev7	420	11	in	in	IN
cord-350836-1enteev7	420	12	ducks	duck	NNS
cord-350836-1enteev7	420	13	(	(	-LRB-
cord-350836-1enteev7	420	14	364	364	CD
cord-350836-1enteev7	420	15	)	)	-RRB-
cord-350836-1enteev7	420	16	and	and	CC
cord-350836-1enteev7	420	17	in	in	IN
cord-350836-1enteev7	420	18	the	the	DT
cord-350836-1enteev7	420	19	Chinese	chinese	JJ
cord-350836-1enteev7	420	20	goose	goose	NN
cord-350836-1enteev7	420	21	(	(	-LRB-
cord-350836-1enteev7	420	22	375	375	CD
cord-350836-1enteev7	420	23	)	)	-RRB-
cord-350836-1enteev7	420	24	in	in	IN
cord-350836-1enteev7	420	25	the	the	DT
cord-350836-1enteev7	420	26	absence	absence	NN
cord-350836-1enteev7	420	27	of	of	IN
cord-350836-1enteev7	420	28	the	the	DT
cord-350836-1enteev7	420	29	K172	K172	NNPS
cord-350836-1enteev7	420	30	activating	activate	VBG
cord-350836-1enteev7	420	31	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	420	32	binding	binding	NN
cord-350836-1enteev7	420	33	site	site	NN
cord-350836-1enteev7	420	34	that	that	WDT
cord-350836-1enteev7	420	35	is	be	VBZ
cord-350836-1enteev7	420	36	conserved	conserve	VBN
cord-350836-1enteev7	420	37	in	in	IN
cord-350836-1enteev7	420	38	primates	primate	NNS
cord-350836-1enteev7	420	39	and	and	CC
cord-350836-1enteev7	420	40	some	some	DT
cord-350836-1enteev7	420	41	rodents	rodent	NNS
cord-350836-1enteev7	420	42	(	(	-LRB-
cord-350836-1enteev7	420	43	364	364	CD
cord-350836-1enteev7	420	44	)	)	-RRB-
cord-350836-1enteev7	420	45	.	.	.
cord-350836-1enteev7	421	1	Finally	finally	RB
cord-350836-1enteev7	421	2	,	,	,
cord-350836-1enteev7	421	3	the	the	DT
cord-350836-1enteev7	421	4	rainbow	rainbow	NN
cord-350836-1enteev7	421	5	trout	trout	NNP
cord-350836-1enteev7	421	6	(	(	-LRB-
cord-350836-1enteev7	421	7	Oncorhynchus	Oncorhynchus	NNP
cord-350836-1enteev7	421	8	mykiss	mykiss	NN
cord-350836-1enteev7	421	9	)	)	-RRB-
cord-350836-1enteev7	421	10	has	have	VBZ
cord-350836-1enteev7	421	11	been	be	VBN
cord-350836-1enteev7	421	12	found	find	VBN
cord-350836-1enteev7	421	13	to	to	TO
cord-350836-1enteev7	421	14	express	express	VB
cord-350836-1enteev7	421	15	a	a	DT
cord-350836-1enteev7	421	16	LGP2	LGP2	NNP
cord-350836-1enteev7	421	17	variant	variant	NN
cord-350836-1enteev7	421	18	in	in	IN
cord-350836-1enteev7	421	19	addition	addition	NN
cord-350836-1enteev7	421	20	to	to	IN
cord-350836-1enteev7	421	21	the	the	DT
cord-350836-1enteev7	421	22	canonical	canonical	JJ
cord-350836-1enteev7	421	23	LGP2	LGP2	NNP
cord-350836-1enteev7	421	24	that	that	WDT
cord-350836-1enteev7	421	25	contains	contain	VBZ
cord-350836-1enteev7	421	26	an	an	DT
cord-350836-1enteev7	421	27	incomplete	incomplete	JJ
cord-350836-1enteev7	421	28	C	c	NN
cord-350836-1enteev7	421	29	-	-	HYPH
cord-350836-1enteev7	421	30	terminal	terminal	NN
cord-350836-1enteev7	421	31	domain	domain	NN
cord-350836-1enteev7	421	32	of	of	IN
cord-350836-1enteev7	421	33	RIG	rig	NN
cord-350836-1enteev7	421	34	-	-	:
cord-350836-1enteev7	421	35	I	i	NN
cord-350836-1enteev7	421	36	(	(	-LRB-
cord-350836-1enteev7	421	37	376	376	CD
cord-350836-1enteev7	421	38	)	)	-RRB-
cord-350836-1enteev7	421	39	.	.	.
cord-350836-1enteev7	422	1	The	the	DT
cord-350836-1enteev7	422	2	differential	differential	JJ
cord-350836-1enteev7	422	3	presence	presence	NN
cord-350836-1enteev7	422	4	of	of	IN
cord-350836-1enteev7	422	5	PRRs	PRRs	NNP
cord-350836-1enteev7	422	6	may	may	MD
cord-350836-1enteev7	422	7	also	also	RB
cord-350836-1enteev7	422	8	influence	influence	VB
cord-350836-1enteev7	422	9	viral	viral	JJ
cord-350836-1enteev7	422	10	evolution	evolution	NN
cord-350836-1enteev7	422	11	.	.	.
cord-350836-1enteev7	423	1	A	a	DT
cord-350836-1enteev7	423	2	mutation	mutation	NN
cord-350836-1enteev7	423	3	in	in	IN
cord-350836-1enteev7	423	4	the	the	DT
cord-350836-1enteev7	423	5	IAV	IAV	NNP
cord-350836-1enteev7	423	6	polymerase	polymerase	NN
cord-350836-1enteev7	423	7	subunit	subunit	NN
cord-350836-1enteev7	423	8	PB2	PB2	NNP
cord-350836-1enteev7	423	9	found	find	VBN
cord-350836-1enteev7	423	10	in	in	IN
cord-350836-1enteev7	423	11	avian	avian	NN
cord-350836-1enteev7	423	12	-	-	HYPH
cord-350836-1enteev7	423	13	adapted	adapt	VBN
cord-350836-1enteev7	423	14	H1N1	H1N1	NNP
cord-350836-1enteev7	423	15	strains	strain	NNS
cord-350836-1enteev7	423	16	decreases	decrease	VBZ
cord-350836-1enteev7	423	17	the	the	DT
cord-350836-1enteev7	423	18	inhibition	inhibition	NN
cord-350836-1enteev7	423	19	of	of	IN
cord-350836-1enteev7	423	20	human	human	JJ
cord-350836-1enteev7	423	21	RIG	rig	NN
cord-350836-1enteev7	423	22	-	-	:
cord-350836-1enteev7	423	23	I	-PRON-	PRP
cord-350836-1enteev7	423	24	function	function	VBP
cord-350836-1enteev7	423	25	by	by	IN
cord-350836-1enteev7	423	26	IAV	IAV	NNP
cord-350836-1enteev7	423	27	nucleoproteins	nucleoprotein	NNS
cord-350836-1enteev7	423	28	,	,	,
cord-350836-1enteev7	423	29	which	which	WDT
cord-350836-1enteev7	423	30	may	may	MD
cord-350836-1enteev7	423	31	indicate	indicate	VB
cord-350836-1enteev7	423	32	a	a	DT
cord-350836-1enteev7	423	33	differential	differential	JJ
cord-350836-1enteev7	423	34	selective	selective	JJ
cord-350836-1enteev7	423	35	pressure	pressure	NN
cord-350836-1enteev7	423	36	for	for	IN
cord-350836-1enteev7	423	37	viruses	virus	NNS
cord-350836-1enteev7	423	38	that	that	WDT
cord-350836-1enteev7	423	39	propagate	propagate	VBP
cord-350836-1enteev7	423	40	in	in	IN
cord-350836-1enteev7	423	41	species	specie	NNS
cord-350836-1enteev7	423	42	that	that	WDT
cord-350836-1enteev7	423	43	do	do	VBP
cord-350836-1enteev7	423	44	n't	not	RB
cord-350836-1enteev7	423	45	contain	contain	VB
cord-350836-1enteev7	423	46	RIG	rig	NN
cord-350836-1enteev7	423	47	-	-	:
cord-350836-1enteev7	423	48	I	i	NN
cord-350836-1enteev7	423	49	(	(	-LRB-
cord-350836-1enteev7	423	50	377	377	CD
cord-350836-1enteev7	423	51	)	)	-RRB-
cord-350836-1enteev7	423	52	.	.	.
cord-350836-1enteev7	424	1	The	the	DT
cord-350836-1enteev7	424	2	evolutionary	evolutionary	JJ
cord-350836-1enteev7	424	3	pattern	pattern	NN
cord-350836-1enteev7	424	4	and	and	CC
cord-350836-1enteev7	424	5	compensatory	compensatory	JJ
cord-350836-1enteev7	424	6	mechanisms	mechanism	NNS
cord-350836-1enteev7	424	7	of	of	IN
cord-350836-1enteev7	424	8	RLRs	rlr	NNS
cord-350836-1enteev7	424	9	across	across	IN
cord-350836-1enteev7	424	10	species	specie	NNS
cord-350836-1enteev7	424	11	implicate	implicate	VBP
cord-350836-1enteev7	424	12	them	-PRON-	PRP
cord-350836-1enteev7	424	13	as	as	IN
cord-350836-1enteev7	424	14	critical	critical	JJ
cord-350836-1enteev7	424	15	for	for	IN
cord-350836-1enteev7	424	16	anti	anti	JJ
cord-350836-1enteev7	424	17	-	-	JJ
cord-350836-1enteev7	424	18	viral	viral	JJ
cord-350836-1enteev7	424	19	function	function	NN
cord-350836-1enteev7	424	20	,	,	,
cord-350836-1enteev7	424	21	and	and	CC
cord-350836-1enteev7	424	22	that	that	IN
cord-350836-1enteev7	424	23	evolutionary	evolutionary	JJ
cord-350836-1enteev7	424	24	forces	force	NNS
cord-350836-1enteev7	424	25	drive	drive	VBP
cord-350836-1enteev7	424	26	the	the	DT
cord-350836-1enteev7	424	27	available	available	JJ
cord-350836-1enteev7	424	28	pathway	pathway	NN
cord-350836-1enteev7	424	29	proteins	protein	NNS
cord-350836-1enteev7	424	30	to	to	TO
cord-350836-1enteev7	424	31	meet	meet	VB
cord-350836-1enteev7	424	32	these	these	DT
cord-350836-1enteev7	424	33	functional	functional	JJ
cord-350836-1enteev7	424	34	needs	need	NNS
cord-350836-1enteev7	424	35	.	.	.
cord-350836-1enteev7	425	1	Future	future	JJ
cord-350836-1enteev7	425	2	studies	study	NNS
cord-350836-1enteev7	425	3	need	need	VBP
cord-350836-1enteev7	425	4	to	to	TO
cord-350836-1enteev7	425	5	be	be	VB
cord-350836-1enteev7	425	6	done	do	VBN
cord-350836-1enteev7	425	7	to	to	TO
cord-350836-1enteev7	425	8	further	further	RB
cord-350836-1enteev7	425	9	differentiate	differentiate	VB
cord-350836-1enteev7	425	10	RLR	RLR	NNP
cord-350836-1enteev7	425	11	function	function	NN
cord-350836-1enteev7	425	12	among	among	IN
cord-350836-1enteev7	425	13	the	the	DT
cord-350836-1enteev7	425	14	different	different	JJ
cord-350836-1enteev7	425	15	species	specie	NNS
cord-350836-1enteev7	425	16	,	,	,
cord-350836-1enteev7	425	17	as	as	IN
cord-350836-1enteev7	425	18	this	this	DT
cord-350836-1enteev7	425	19	will	will	MD
cord-350836-1enteev7	425	20	provide	provide	VB
cord-350836-1enteev7	425	21	critical	critical	JJ
cord-350836-1enteev7	425	22	information	information	NN
cord-350836-1enteev7	425	23	concerning	concern	VBG
cord-350836-1enteev7	425	24	the	the	DT
cord-350836-1enteev7	425	25	various	various	JJ
cord-350836-1enteev7	425	26	methods	method	NNS
cord-350836-1enteev7	425	27	of	of	IN
cord-350836-1enteev7	425	28	disease	disease	NN
cord-350836-1enteev7	425	29	control	control	NN
cord-350836-1enteev7	425	30	by	by	IN
cord-350836-1enteev7	425	31	targeting	target	VBG
cord-350836-1enteev7	425	32	the	the	DT
cord-350836-1enteev7	425	33	pathogen	pathogen	NN
cord-350836-1enteev7	425	34	by	by	IN
cord-350836-1enteev7	425	35	these	these	DT
cord-350836-1enteev7	425	36	important	important	JJ
cord-350836-1enteev7	425	37	host	host	NN
cord-350836-1enteev7	425	38	proteins	protein	NNS
cord-350836-1enteev7	425	39	.	.	.
cord-350836-1enteev7	426	1	There	there	EX
cord-350836-1enteev7	426	2	is	be	VBZ
cord-350836-1enteev7	426	3	also	also	RB
cord-350836-1enteev7	426	4	increasing	increase	VBG
cord-350836-1enteev7	426	5	evidence	evidence	NN
cord-350836-1enteev7	426	6	for	for	IN
cord-350836-1enteev7	426	7	other	other	JJ
cord-350836-1enteev7	426	8	RNA	RNA	NNP
cord-350836-1enteev7	426	9	-	-	HYPH
cord-350836-1enteev7	426	10	sensing	sensing	NN
cord-350836-1enteev7	426	11	DExD	DExD	NNS
cord-350836-1enteev7	426	12	/	/	SYM
cord-350836-1enteev7	426	13	H	h	NN
cord-350836-1enteev7	426	14	helicases	helicase	NNS
cord-350836-1enteev7	426	15	serving	serve	VBG
cord-350836-1enteev7	426	16	important	important	JJ
cord-350836-1enteev7	426	17	roles	role	NNS
cord-350836-1enteev7	426	18	in	in	IN
cord-350836-1enteev7	426	19	anti	anti	JJ
cord-350836-1enteev7	426	20	-	-	JJ
cord-350836-1enteev7	426	21	pathogen	pathogen	JJ
cord-350836-1enteev7	426	22	immune	immune	JJ
cord-350836-1enteev7	426	23	sensing	sensing	NN
cord-350836-1enteev7	426	24	,	,	,
cord-350836-1enteev7	426	25	which	which	WDT
cord-350836-1enteev7	426	26	have	have	VBP
cord-350836-1enteev7	426	27	recently	recently	RB
cord-350836-1enteev7	426	28	been	be	VBN
cord-350836-1enteev7	426	29	reviewed	review	VBN
cord-350836-1enteev7	426	30	elsewhere	elsewhere	RB
cord-350836-1enteev7	426	31	(	(	-LRB-
cord-350836-1enteev7	426	32	187	187	CD
cord-350836-1enteev7	426	33	)	)	-RRB-
cord-350836-1enteev7	426	34	.	.	.
cord-350836-1enteev7	427	1	Some	some	DT
cord-350836-1enteev7	427	2	RNA	RNA	NNP
cord-350836-1enteev7	427	3	helicase	helicase	NN
cord-350836-1enteev7	427	4	(	(	-LRB-
cord-350836-1enteev7	427	5	DDX	DDX	NNP
cord-350836-1enteev7	427	6	)	)	-RRB-
cord-350836-1enteev7	427	7	proteins	protein	NNS
cord-350836-1enteev7	427	8	appear	appear	VBP
cord-350836-1enteev7	427	9	to	to	TO
cord-350836-1enteev7	427	10	serve	serve	VB
cord-350836-1enteev7	427	11	as	as	IN
cord-350836-1enteev7	427	12	complex	complex	JJ
cord-350836-1enteev7	427	13	proteins	protein	NNS
cord-350836-1enteev7	427	14	upon	upon	IN
cord-350836-1enteev7	427	15	interacting	interact	VBG
cord-350836-1enteev7	427	16	with	with	IN
cord-350836-1enteev7	427	17	viral	viral	JJ
cord-350836-1enteev7	427	18	RNA	RNA	NNP
cord-350836-1enteev7	427	19	.	.	.
cord-350836-1enteev7	428	1	DDX3	DDX3	NNP
cord-350836-1enteev7	428	2	is	be	VBZ
cord-350836-1enteev7	428	3	a	a	DT
cord-350836-1enteev7	428	4	well	well	RB
cord-350836-1enteev7	428	5	-	-	HYPH
cord-350836-1enteev7	428	6	known	know	VBN
cord-350836-1enteev7	428	7	example	example	NN
cord-350836-1enteev7	428	8	,	,	,
cord-350836-1enteev7	428	9	being	be	VBG
cord-350836-1enteev7	428	10	suspected	suspect	VBN
cord-350836-1enteev7	428	11	of	of	IN
cord-350836-1enteev7	428	12	being	be	VBG
cord-350836-1enteev7	428	13	a	a	DT
cord-350836-1enteev7	428	14	transcription	transcription	NN
cord-350836-1enteev7	428	15	factor	factor	NN
cord-350836-1enteev7	428	16	for	for	IN
cord-350836-1enteev7	428	17	IFN	IFN	NNP
cord-350836-1enteev7	428	18	-	-	HYPH
cord-350836-1enteev7	428	19	β	β	NNP
cord-350836-1enteev7	428	20	(	(	-LRB-
cord-350836-1enteev7	428	21	378	378	CD
cord-350836-1enteev7	428	22	)	)	-RRB-
cord-350836-1enteev7	428	23	,	,	,
cord-350836-1enteev7	428	24	associating	associate	VBG
cord-350836-1enteev7	428	25	with	with	IN
cord-350836-1enteev7	428	26	spliceosomes	spliceosome	NNS
cord-350836-1enteev7	428	27	and	and	CC
cord-350836-1enteev7	428	28	the	the	DT
cord-350836-1enteev7	428	29	stress	stress	NN
cord-350836-1enteev7	428	30	-	-	HYPH
cord-350836-1enteev7	428	31	induced	induce	VBN
cord-350836-1enteev7	428	32	p	p	NN
cord-350836-1enteev7	428	33	-	-	,
cord-350836-1enteev7	428	34	bodies	body	NNS
cord-350836-1enteev7	428	35	to	to	TO
cord-350836-1enteev7	428	36	influence	influence	VB
cord-350836-1enteev7	428	37	mRNA	mrna	NN
cord-350836-1enteev7	428	38	splicing	splicing	NN
cord-350836-1enteev7	428	39	and	and	CC
cord-350836-1enteev7	428	40	decay	decay	NN
cord-350836-1enteev7	428	41	,	,	,
cord-350836-1enteev7	428	42	respectively	respectively	RB
cord-350836-1enteev7	428	43	(	(	-LRB-
cord-350836-1enteev7	428	44	322	322	CD
cord-350836-1enteev7	428	45	,	,	,
cord-350836-1enteev7	428	46	378	378	CD
cord-350836-1enteev7	428	47	)	)	-RRB-
cord-350836-1enteev7	428	48	,	,	,
cord-350836-1enteev7	428	49	and	and	CC
cord-350836-1enteev7	428	50	interacting	interact	VBG
cord-350836-1enteev7	428	51	with	with	IN
cord-350836-1enteev7	428	52	the	the	DT
cord-350836-1enteev7	428	53	MAVS	MAVS	NNPS
cord-350836-1enteev7	428	54	complex	complex	JJ
cord-350836-1enteev7	428	55	during	during	IN
cord-350836-1enteev7	428	56	viral	viral	JJ
cord-350836-1enteev7	428	57	infection	infection	NN
cord-350836-1enteev7	428	58	conditions	condition	NNS
cord-350836-1enteev7	428	59	(	(	-LRB-
cord-350836-1enteev7	428	60	378	378	CD
cord-350836-1enteev7	428	61	,	,	,
cord-350836-1enteev7	428	62	379	379	CD
cord-350836-1enteev7	428	63	)	)	-RRB-
cord-350836-1enteev7	428	64	.	.	.
cord-350836-1enteev7	429	1	In	in	IN
cord-350836-1enteev7	429	2	particular	particular	JJ
cord-350836-1enteev7	429	3	,	,	,
cord-350836-1enteev7	429	4	DDX3	DDX3	NNP
cord-350836-1enteev7	429	5	associating	associate	VBG
cord-350836-1enteev7	429	6	with	with	IN
cord-350836-1enteev7	429	7	MAVS	MAVS	NNPS
cord-350836-1enteev7	429	8	has	have	VBZ
cord-350836-1enteev7	429	9	been	be	VBN
cord-350836-1enteev7	429	10	found	find	VBN
cord-350836-1enteev7	429	11	to	to	TO
cord-350836-1enteev7	429	12	be	be	VB
cord-350836-1enteev7	429	13	important	important	JJ
cord-350836-1enteev7	429	14	for	for	IN
cord-350836-1enteev7	429	15	anti	anti	JJ
cord-350836-1enteev7	429	16	-	-	JJ
cord-350836-1enteev7	429	17	viral	viral	JJ
cord-350836-1enteev7	429	18	control	control	NN
cord-350836-1enteev7	429	19	against	against	IN
cord-350836-1enteev7	429	20	several	several	JJ
cord-350836-1enteev7	429	21	viruses	virus	NNS
cord-350836-1enteev7	429	22	(	(	-LRB-
cord-350836-1enteev7	429	23	378	378	CD
cord-350836-1enteev7	429	24	)	)	-RRB-
cord-350836-1enteev7	429	25	(	(	-LRB-
cord-350836-1enteev7	429	26	379	379	CD
cord-350836-1enteev7	429	27	)	)	-RRB-
cord-350836-1enteev7	429	28	(	(	-LRB-
cord-350836-1enteev7	429	29	380	380	CD
cord-350836-1enteev7	429	30	)	)	-RRB-
cord-350836-1enteev7	429	31	,	,	,
cord-350836-1enteev7	429	32	and	and	CC
cord-350836-1enteev7	429	33	since	since	IN
cord-350836-1enteev7	429	34	the	the	DT
cord-350836-1enteev7	429	35	two	two	CD
cord-350836-1enteev7	429	36	DDX3	DDX3	NNP
cord-350836-1enteev7	429	37	homologs	homolog	NNS
cord-350836-1enteev7	429	38	are	be	VBP
cord-350836-1enteev7	429	39	found	find	VBN
cord-350836-1enteev7	429	40	on	on	IN
cord-350836-1enteev7	429	41	the	the	DT
cord-350836-1enteev7	429	42	X	x	NN
cord-350836-1enteev7	429	43	and	and	CC
cord-350836-1enteev7	429	44	Y	Y	NNP
cord-350836-1enteev7	429	45	chromosomes	chromosome	NNS
cord-350836-1enteev7	429	46	,	,	,
cord-350836-1enteev7	429	47	they	-PRON-	PRP
cord-350836-1enteev7	429	48	may	may	MD
cord-350836-1enteev7	429	49	contribute	contribute	VB
cord-350836-1enteev7	429	50	to	to	IN
cord-350836-1enteev7	429	51	immunological	immunological	JJ
cord-350836-1enteev7	429	52	differences	difference	NNS
cord-350836-1enteev7	429	53	between	between	IN
cord-350836-1enteev7	429	54	genders	gender	NNS
cord-350836-1enteev7	429	55	(	(	-LRB-
cord-350836-1enteev7	429	56	381	381	CD
cord-350836-1enteev7	429	57	)	)	-RRB-
cord-350836-1enteev7	429	58	.	.	.
cord-350836-1enteev7	430	1	This	this	DT
cord-350836-1enteev7	430	2	is	be	VBZ
cord-350836-1enteev7	430	3	a	a	DT
cord-350836-1enteev7	430	4	repeated	repeated	JJ
cord-350836-1enteev7	430	5	theme	theme	NN
cord-350836-1enteev7	430	6	,	,	,
cord-350836-1enteev7	430	7	as	as	IN
cord-350836-1enteev7	430	8	DHX9	DHX9	NNP
cord-350836-1enteev7	430	9	(	(	-LRB-
cord-350836-1enteev7	430	10	382	382	CD
cord-350836-1enteev7	430	11	)	)	-RRB-
cord-350836-1enteev7	430	12	,	,	,
cord-350836-1enteev7	430	13	DHX15	DHX15	NNP
cord-350836-1enteev7	430	14	(	(	-LRB-
cord-350836-1enteev7	430	15	383	383	CD
cord-350836-1enteev7	430	16	)	)	-RRB-
cord-350836-1enteev7	430	17	,	,	,
cord-350836-1enteev7	430	18	and	and	CC
cord-350836-1enteev7	430	19	a	a	DT
cord-350836-1enteev7	430	20	complex	complex	JJ
cord-350836-1enteev7	430	21	consisting	consisting	NN
cord-350836-1enteev7	430	22	of	of	IN
cord-350836-1enteev7	430	23	DDX1	DDX1	NNP
cord-350836-1enteev7	430	24	/	/	SYM
cord-350836-1enteev7	430	25	DDX21	DDX21	NNP
cord-350836-1enteev7	430	26	/	/	SYM
cord-350836-1enteev7	430	27	DHX36	DHX36	NNP
cord-350836-1enteev7	430	28	(	(	-LRB-
cord-350836-1enteev7	430	29	384	384	CD
cord-350836-1enteev7	430	30	)	)	-RRB-
cord-350836-1enteev7	430	31	have	have	VBP
cord-350836-1enteev7	430	32	also	also	RB
cord-350836-1enteev7	430	33	been	be	VBN
cord-350836-1enteev7	430	34	found	find	VBN
cord-350836-1enteev7	430	35	to	to	TO
cord-350836-1enteev7	430	36	associate	associate	VB
cord-350836-1enteev7	430	37	with	with	IN
cord-350836-1enteev7	430	38	the	the	DT
cord-350836-1enteev7	430	39	MAVS	MAVS	NNPS
cord-350836-1enteev7	430	40	complex	complex	JJ
cord-350836-1enteev7	430	41	to	to	TO
cord-350836-1enteev7	430	42	enhance	enhance	VB
cord-350836-1enteev7	430	43	IFN1	IFN1	NNP
cord-350836-1enteev7	430	44	signaling	signaling	NN
cord-350836-1enteev7	430	45	,	,	,
cord-350836-1enteev7	430	46	while	while	IN
cord-350836-1enteev7	430	47	DHX33	DHX33	NNP
cord-350836-1enteev7	430	48	interacts	interact	VBZ
cord-350836-1enteev7	430	49	with	with	IN
cord-350836-1enteev7	430	50	MAVS	MAVS	NNPS
cord-350836-1enteev7	430	51	independently	independently	RB
cord-350836-1enteev7	430	52	of	of	IN
cord-350836-1enteev7	430	53	viral	viral	JJ
cord-350836-1enteev7	430	54	infection	infection	NN
cord-350836-1enteev7	430	55	(	(	-LRB-
cord-350836-1enteev7	430	56	385	385	CD
cord-350836-1enteev7	430	57	)	)	-RRB-
cord-350836-1enteev7	430	58	.	.	.
cord-350836-1enteev7	431	1	DDX	DDX	NNP
cord-350836-1enteev7	431	2	proteins	protein	NNS
cord-350836-1enteev7	431	3	can	can	MD
cord-350836-1enteev7	431	4	also	also	RB
cord-350836-1enteev7	431	5	activate	activate	VB
cord-350836-1enteev7	431	6	other	other	JJ
cord-350836-1enteev7	431	7	proteins	protein	NNS
cord-350836-1enteev7	431	8	in	in	IN
cord-350836-1enteev7	431	9	the	the	DT
cord-350836-1enteev7	431	10	IRF	IRF	NNP
cord-350836-1enteev7	431	11	pathway	pathway	NN
cord-350836-1enteev7	431	12	.	.	.
cord-350836-1enteev7	432	1	Multiple	multiple	JJ
cord-350836-1enteev7	432	2	DDX	DDX	NNP
cord-350836-1enteev7	432	3	proteins	protein	NNS
cord-350836-1enteev7	432	4	can	can	MD
cord-350836-1enteev7	432	5	interact	interact	VB
cord-350836-1enteev7	432	6	with	with	IN
cord-350836-1enteev7	432	7	IKKε	IKKε	NNS
cord-350836-1enteev7	432	8	,	,	,
cord-350836-1enteev7	432	9	with	with	IN
cord-350836-1enteev7	432	10	DDX3	DDX3	NNP
cord-350836-1enteev7	432	11	being	be	VBG
cord-350836-1enteev7	432	12	phosphorylated	phosphorylate	VBN
cord-350836-1enteev7	432	13	by	by	IN
cord-350836-1enteev7	432	14	IKKε	IKKε	NNS
cord-350836-1enteev7	432	15	to	to	TO
cord-350836-1enteev7	432	16	induce	induce	VB
cord-350836-1enteev7	432	17	IRF3	IRF3	NNP
cord-350836-1enteev7	432	18	interaction	interaction	NN
cord-350836-1enteev7	432	19	with	with	IN
cord-350836-1enteev7	432	20	the	the	DT
cord-350836-1enteev7	432	21	TBK1-IKKε	TBK1-IKKε	NNP
cord-350836-1enteev7	432	22	complex	complex	NN
cord-350836-1enteev7	432	23	(	(	-LRB-
cord-350836-1enteev7	432	24	378	378	CD
cord-350836-1enteev7	432	25	)	)	-RRB-
cord-350836-1enteev7	432	26	,	,	,
cord-350836-1enteev7	432	27	and	and	CC
cord-350836-1enteev7	432	28	DDX19	ddx19	UH
cord-350836-1enteev7	432	29	blocking	block	VBG
cord-350836-1enteev7	432	30	this	this	DT
cord-350836-1enteev7	432	31	interaction	interaction	NN
cord-350836-1enteev7	432	32	to	to	TO
cord-350836-1enteev7	432	33	inhibit	inhibit	VB
cord-350836-1enteev7	432	34	IFN1	IFN1	NNP
cord-350836-1enteev7	432	35	signaling	signal	VBG
cord-350836-1enteev7	432	36	(	(	-LRB-
cord-350836-1enteev7	432	37	386	386	CD
cord-350836-1enteev7	432	38	)	)	-RRB-
cord-350836-1enteev7	432	39	.	.	.
cord-350836-1enteev7	433	1	Similar	similar	JJ
cord-350836-1enteev7	433	2	control	control	NN
cord-350836-1enteev7	433	3	mechanisms	mechanism	NNS
cord-350836-1enteev7	433	4	have	have	VBP
cord-350836-1enteev7	433	5	been	be	VBN
cord-350836-1enteev7	433	6	demonstrated	demonstrate	VBN
cord-350836-1enteev7	433	7	for	for	IN
cord-350836-1enteev7	433	8	DDX3	DDX3	NNP
cord-350836-1enteev7	433	9	interacting	interact	VBG
cord-350836-1enteev7	433	10	with	with	IN
cord-350836-1enteev7	433	11	viral	viral	JJ
cord-350836-1enteev7	433	12	proteins	protein	NNS
cord-350836-1enteev7	433	13	.	.	.
cord-350836-1enteev7	434	1	For	for	IN
cord-350836-1enteev7	434	2	example	example	NN
cord-350836-1enteev7	434	3	,	,	,
cord-350836-1enteev7	434	4	DDX3	DDX3	NNP
cord-350836-1enteev7	434	5	has	have	VBZ
cord-350836-1enteev7	434	6	recently	recently	RB
cord-350836-1enteev7	434	7	been	be	VBN
cord-350836-1enteev7	434	8	found	find	VBN
cord-350836-1enteev7	434	9	to	to	TO
cord-350836-1enteev7	434	10	associate	associate	VB
cord-350836-1enteev7	434	11	with	with	IN
cord-350836-1enteev7	434	12	arenaviral	arenaviral	NNP
cord-350836-1enteev7	434	13	NPs	NPs	NNPS
cord-350836-1enteev7	434	14	to	to	TO
cord-350836-1enteev7	434	15	increase	increase	VB
cord-350836-1enteev7	434	16	viral	viral	JJ
cord-350836-1enteev7	434	17	RNA	RNA	NNP
cord-350836-1enteev7	434	18	synthesis	synthesis	NN
cord-350836-1enteev7	434	19	and	and	CC
cord-350836-1enteev7	434	20	IFN1	IFN1	NNP
cord-350836-1enteev7	434	21	expression	expression	NN
cord-350836-1enteev7	434	22	(	(	-LRB-
cord-350836-1enteev7	434	23	387	387	CD
cord-350836-1enteev7	434	24	)	)	-RRB-
cord-350836-1enteev7	434	25	.	.	.
cord-350836-1enteev7	435	1	Additionally	additionally	RB
cord-350836-1enteev7	435	2	,	,	,
cord-350836-1enteev7	435	3	the	the	DT
cord-350836-1enteev7	435	4	NP	NP	NNP
cord-350836-1enteev7	435	5	of	of	IN
cord-350836-1enteev7	435	6	the	the	DT
cord-350836-1enteev7	435	7	1918	1918	CD
cord-350836-1enteev7	435	8	H1N1	H1N1	NNP
cord-350836-1enteev7	435	9	IAV	IAV	NNP
cord-350836-1enteev7	435	10	pandemic	pandemic	NN
cord-350836-1enteev7	435	11	strain	strain	NN
cord-350836-1enteev7	435	12	has	have	VBZ
cord-350836-1enteev7	435	13	been	be	VBN
cord-350836-1enteev7	435	14	shown	show	VBN
cord-350836-1enteev7	435	15	to	to	TO
cord-350836-1enteev7	435	16	target	target	VB
cord-350836-1enteev7	435	17	DDX3	DDX3	NNP
cord-350836-1enteev7	435	18	for	for	IN
cord-350836-1enteev7	435	19	degradation	degradation	NN
cord-350836-1enteev7	435	20	as	as	IN
cord-350836-1enteev7	435	21	a	a	DT
cord-350836-1enteev7	435	22	potential	potential	JJ
cord-350836-1enteev7	435	23	mechanism	mechanism	NN
cord-350836-1enteev7	435	24	of	of	IN
cord-350836-1enteev7	435	25	virulence	virulence	NN
cord-350836-1enteev7	435	26	(	(	-LRB-
cord-350836-1enteev7	435	27	388	388	CD
cord-350836-1enteev7	435	28	)	)	-RRB-
cord-350836-1enteev7	435	29	.	.	.
cord-350836-1enteev7	436	1	DHX15	dhx15	RB
cord-350836-1enteev7	437	1	(	(	-LRB-
cord-350836-1enteev7	437	2	389	389	CD
cord-350836-1enteev7	437	3	)	)	-RRB-
cord-350836-1enteev7	437	4	and	and	CC
cord-350836-1enteev7	437	5	DHX33	DHX33	NNP
cord-350836-1enteev7	437	6	have	have	VBP
cord-350836-1enteev7	437	7	also	also	RB
cord-350836-1enteev7	437	8	been	be	VBN
cord-350836-1enteev7	437	9	found	find	VBN
cord-350836-1enteev7	437	10	to	to	TO
cord-350836-1enteev7	437	11	activate	activate	VB
cord-350836-1enteev7	437	12	NFκB	NFκB	NNP
cord-350836-1enteev7	437	13	and	and	CC
cord-350836-1enteev7	437	14	MAPK	MAPK	NNP
cord-350836-1enteev7	437	15	signaling	signal	VBG
cord-350836-1enteev7	437	16	pathways	pathway	NNS
cord-350836-1enteev7	437	17	.	.	.
cord-350836-1enteev7	438	1	Finally	finally	RB
cord-350836-1enteev7	438	2	,	,	,
cord-350836-1enteev7	438	3	DDX60	DDX60	NNP
cord-350836-1enteev7	438	4	has	have	VBZ
cord-350836-1enteev7	438	5	been	be	VBN
cord-350836-1enteev7	438	6	shown	show	VBN
cord-350836-1enteev7	438	7	to	to	TO
cord-350836-1enteev7	438	8	act	act	VB
cord-350836-1enteev7	438	9	as	as	IN
cord-350836-1enteev7	438	10	a	a	DT
cord-350836-1enteev7	438	11	cofactor	cofactor	NN
cord-350836-1enteev7	438	12	for	for	IN
cord-350836-1enteev7	438	13	RIG	rig	NN
cord-350836-1enteev7	438	14	-	-	:
cord-350836-1enteev7	438	15	I	i	NN
cord-350836-1enteev7	438	16	(	(	-LRB-
cord-350836-1enteev7	438	17	390	390	CD
cord-350836-1enteev7	438	18	,	,	,
cord-350836-1enteev7	438	19	391	391	CD
cord-350836-1enteev7	438	20	)	)	-RRB-
cord-350836-1enteev7	438	21	and	and	CC
cord-350836-1enteev7	438	22	DHX29	dhx29	VBP
cord-350836-1enteev7	438	23	for	for	IN
cord-350836-1enteev7	438	24	MDA5	MDA5	NNP
cord-350836-1enteev7	438	25	(	(	-LRB-
cord-350836-1enteev7	438	26	392	392	CD
cord-350836-1enteev7	438	27	)	)	-RRB-
cord-350836-1enteev7	438	28	.	.	.
cord-350836-1enteev7	439	1	Taken	take	VBN
cord-350836-1enteev7	439	2	altogether	altogether	RB
cord-350836-1enteev7	439	3	,	,	,
cord-350836-1enteev7	439	4	these	these	DT
cord-350836-1enteev7	439	5	cellular	cellular	JJ
cord-350836-1enteev7	439	6	proteins	protein	NNS
cord-350836-1enteev7	439	7	have	have	VBP
cord-350836-1enteev7	439	8	likely	likely	RB
cord-350836-1enteev7	439	9	evolved	evolve	VBN
cord-350836-1enteev7	439	10	to	to	TO
cord-350836-1enteev7	439	11	regulate	regulate	VB
cord-350836-1enteev7	439	12	RIG	rig	NN
cord-350836-1enteev7	439	13	-	-	:
cord-350836-1enteev7	439	14	I	I	NNP
cord-350836-1enteev7	439	15	and	and	CC
cord-350836-1enteev7	439	16	MDA5	MDA5	NNP
cord-350836-1enteev7	439	17	signaling	signal	VBG
cord-350836-1enteev7	439	18	from	from	IN
cord-350836-1enteev7	439	19	their	-PRON-	PRP$
cord-350836-1enteev7	439	20	common	common	JJ
cord-350836-1enteev7	439	21	DExD	DExD	NNS
cord-350836-1enteev7	439	22	/	/	SYM
cord-350836-1enteev7	439	23	H	h	NN
cord-350836-1enteev7	439	24	helicase	helicase	NN
cord-350836-1enteev7	439	25	predecessors	predecessor	NNS
cord-350836-1enteev7	439	26	.	.	.
cord-350836-1enteev7	440	1	As	as	IN
cord-350836-1enteev7	440	2	our	-PRON-	PRP$
cord-350836-1enteev7	440	3	capacity	capacity	NN
cord-350836-1enteev7	440	4	to	to	TO
cord-350836-1enteev7	440	5	study	study	VB
cord-350836-1enteev7	440	6	the	the	DT
cord-350836-1enteev7	440	7	molecular	molecular	JJ
cord-350836-1enteev7	440	8	mechanisms	mechanism	NNS
cord-350836-1enteev7	440	9	and	and	CC
cord-350836-1enteev7	440	10	to	to	TO
cord-350836-1enteev7	440	11	purposefully	purposefully	RB
cord-350836-1enteev7	440	12	modulate	modulate	VB
cord-350836-1enteev7	440	13	immune	immune	JJ
cord-350836-1enteev7	440	14	responses	response	NNS
cord-350836-1enteev7	440	15	increases	increase	NNS
cord-350836-1enteev7	440	16	in	in	IN
cord-350836-1enteev7	440	17	specificity	specificity	NN
cord-350836-1enteev7	440	18	,	,	,
cord-350836-1enteev7	440	19	so	so	RB
cord-350836-1enteev7	440	20	will	will	MD
cord-350836-1enteev7	440	21	our	-PRON-	PRP$
cord-350836-1enteev7	440	22	needs	need	NNS
cord-350836-1enteev7	440	23	to	to	TO
cord-350836-1enteev7	440	24	characterize	characterize	VB
cord-350836-1enteev7	440	25	the	the	DT
cord-350836-1enteev7	440	26	differences	difference	NNS
cord-350836-1enteev7	440	27	between	between	IN
cord-350836-1enteev7	440	28	related	related	JJ
cord-350836-1enteev7	440	29	immune	immune	NN
cord-350836-1enteev7	440	30	signaling	signal	VBG
cord-350836-1enteev7	440	31	proteins	protein	NNS
cord-350836-1enteev7	440	32	.	.	.
cord-350836-1enteev7	441	1	The	the	DT
cord-350836-1enteev7	441	2	concept	concept	NN
cord-350836-1enteev7	441	3	of	of	IN
cord-350836-1enteev7	441	4	personalized	personalized	JJ
cord-350836-1enteev7	441	5	medicine	medicine	NN
cord-350836-1enteev7	441	6	derives	derive	VBZ
cord-350836-1enteev7	441	7	from	from	IN
cord-350836-1enteev7	441	8	the	the	DT
cord-350836-1enteev7	441	9	idea	idea	NN
cord-350836-1enteev7	441	10	that	that	IN
cord-350836-1enteev7	441	11	we	-PRON-	PRP
cord-350836-1enteev7	441	12	can	can	MD
cord-350836-1enteev7	441	13	therapeutically	therapeutically	RB
cord-350836-1enteev7	441	14	intervene	intervene	VB
cord-350836-1enteev7	441	15	in	in	IN
cord-350836-1enteev7	441	16	a	a	DT
cord-350836-1enteev7	441	17	situation	situation	NN
cord-350836-1enteev7	441	18	that	that	WDT
cord-350836-1enteev7	441	19	is	be	VBZ
cord-350836-1enteev7	441	20	designed	design	VBN
cord-350836-1enteev7	441	21	around	around	IN
cord-350836-1enteev7	441	22	the	the	DT
cord-350836-1enteev7	441	23	individual	individual	NN
cord-350836-1enteev7	441	24	's	's	POS
cord-350836-1enteev7	441	25	unique	unique	JJ
cord-350836-1enteev7	441	26	characteristics	characteristic	NNS
cord-350836-1enteev7	441	27	.	.	.
cord-350836-1enteev7	442	1	While	while	IN
cord-350836-1enteev7	442	2	this	this	DT
cord-350836-1enteev7	442	3	is	be	VBZ
cord-350836-1enteev7	442	4	an	an	DT
cord-350836-1enteev7	442	5	achievable	achievable	JJ
cord-350836-1enteev7	442	6	realm	realm	NN
cord-350836-1enteev7	442	7	of	of	IN
cord-350836-1enteev7	442	8	medicine	medicine	NN
cord-350836-1enteev7	442	9	in	in	IN
cord-350836-1enteev7	442	10	the	the	DT
cord-350836-1enteev7	442	11	future	future	NN
cord-350836-1enteev7	442	12	,	,	,
cord-350836-1enteev7	442	13	an	an	DT
cord-350836-1enteev7	442	14	immediate	immediate	JJ
cord-350836-1enteev7	442	15	step	step	NN
cord-350836-1enteev7	442	16	is	be	VBZ
cord-350836-1enteev7	442	17	to	to	TO
cord-350836-1enteev7	442	18	determine	determine	VB
cord-350836-1enteev7	442	19	the	the	DT
cord-350836-1enteev7	442	20	functions	function	NNS
cord-350836-1enteev7	442	21	of	of	IN
cord-350836-1enteev7	442	22	some	some	DT
cord-350836-1enteev7	442	23	critical	critical	JJ
cord-350836-1enteev7	442	24	proteins	protein	NNS
cord-350836-1enteev7	442	25	,	,	,
cord-350836-1enteev7	442	26	such	such	JJ
cord-350836-1enteev7	442	27	as	as	IN
cord-350836-1enteev7	442	28	the	the	DT
cord-350836-1enteev7	442	29	RIG	rig	NN
cord-350836-1enteev7	442	30	-	-	:
cord-350836-1enteev7	442	31	I	I	NNP
cord-350836-1enteev7	442	32	and	and	CC
cord-350836-1enteev7	442	33	MDA5	MDA5	NNP
cord-350836-1enteev7	442	34	of	of	IN
cord-350836-1enteev7	442	35	the	the	DT
cord-350836-1enteev7	442	36	innate	innate	JJ
cord-350836-1enteev7	442	37	immune	immune	JJ
cord-350836-1enteev7	442	38	arm	arm	NN
cord-350836-1enteev7	442	39	.	.	.
cord-350836-1enteev7	443	1	Examining	examine	VBG
cord-350836-1enteev7	443	2	their	-PRON-	PRP$
cord-350836-1enteev7	443	3	structural	structural	JJ
cord-350836-1enteev7	443	4	and	and	CC
cord-350836-1enteev7	443	5	functional	functional	JJ
cord-350836-1enteev7	443	6	similarities	similarity	NNS
cord-350836-1enteev7	443	7	and	and	CC
cord-350836-1enteev7	443	8	differences	difference	NNS
cord-350836-1enteev7	443	9	at	at	IN
cord-350836-1enteev7	443	10	multiple	multiple	JJ
cord-350836-1enteev7	443	11	levels	level	NNS
cord-350836-1enteev7	443	12	will	will	MD
cord-350836-1enteev7	443	13	allow	allow	VB
cord-350836-1enteev7	443	14	for	for	IN
cord-350836-1enteev7	443	15	a	a	DT
cord-350836-1enteev7	443	16	deeper	deep	JJR
cord-350836-1enteev7	443	17	level	level	NN
cord-350836-1enteev7	443	18	of	of	IN
cord-350836-1enteev7	443	19	appreciation	appreciation	NN
cord-350836-1enteev7	443	20	of	of	IN
cord-350836-1enteev7	443	21	these	these	DT
cord-350836-1enteev7	443	22	proteins	protein	NNS
cord-350836-1enteev7	443	23	,	,	,
cord-350836-1enteev7	443	24	which	which	WDT
cord-350836-1enteev7	443	25	may	may	MD
cord-350836-1enteev7	443	26	be	be	VB
cord-350836-1enteev7	443	27	exploited	exploit	VBN
cord-350836-1enteev7	443	28	therapeutically	therapeutically	RB
cord-350836-1enteev7	443	29	to	to	TO
cord-350836-1enteev7	443	30	differentially	differentially	RB
cord-350836-1enteev7	443	31	modulate	modulate	VB
cord-350836-1enteev7	443	32	RIG	rig	NN
cord-350836-1enteev7	443	33	-	-	:
cord-350836-1enteev7	443	34	I	I	NNP
cord-350836-1enteev7	443	35	and	and	CC
cord-350836-1enteev7	443	36	MDA5	mda5	JJ
cord-350836-1enteev7	443	37	signalings	signaling	NNS
cord-350836-1enteev7	443	38	by	by	IN
cord-350836-1enteev7	443	39	different	different	JJ
cord-350836-1enteev7	443	40	RNA	RNA	NNP
cord-350836-1enteev7	443	41	ligands	ligand	NNS
cord-350836-1enteev7	443	42	(	(	-LRB-
cord-350836-1enteev7	443	43	43	43	CD
cord-350836-1enteev7	443	44	,	,	,
cord-350836-1enteev7	443	45	191	191	CD
cord-350836-1enteev7	443	46	,	,	,
cord-350836-1enteev7	443	47	393	393	CD
cord-350836-1enteev7	443	48	,	,	,
cord-350836-1enteev7	443	49	394	394	CD
cord-350836-1enteev7	443	50	)	)	-RRB-
cord-350836-1enteev7	443	51	or	or	CC
cord-350836-1enteev7	443	52	other	other	JJ
cord-350836-1enteev7	443	53	pharmaceutical	pharmaceutical	JJ
cord-350836-1enteev7	443	54	compounds	compound	NNS
cord-350836-1enteev7	443	55	(	(	-LRB-
cord-350836-1enteev7	443	56	395	395	CD
cord-350836-1enteev7	443	57	)	)	-RRB-
cord-350836-1enteev7	443	58	 	 	_SP
cord-350836-1enteev7	444	1	RIG	rig	NN
cord-350836-1enteev7	444	2	-	-	:
cord-350836-1enteev7	444	3	I	I	NNP
cord-350836-1enteev7	444	4	,	,	,
cord-350836-1enteev7	444	5	a	a	DT
cord-350836-1enteev7	444	6	human	human	JJ
cord-350836-1enteev7	444	7	homolog	homolog	NN
cord-350836-1enteev7	444	8	gene	gene	NN
cord-350836-1enteev7	444	9	of	of	IN
cord-350836-1enteev7	444	10	RNA	RNA	NNP
cord-350836-1enteev7	444	11	helicase	helicase	NNP
cord-350836-1enteev7	444	12	,	,	,
cord-350836-1enteev7	444	13	is	be	VBZ
cord-350836-1enteev7	444	14	induced	induce	VBN
cord-350836-1enteev7	444	15	by	by	IN
cord-350836-1enteev7	444	16	retinoic	retinoic	JJ
cord-350836-1enteev7	444	17	acid	acid	NN
cord-350836-1enteev7	444	18	during	during	IN
cord-350836-1enteev7	444	19	the	the	DT
cord-350836-1enteev7	444	20	differentiation	differentiation	NN
cord-350836-1enteev7	444	21	of	of	IN
cord-350836-1enteev7	444	22	acute	acute	JJ
cord-350836-1enteev7	444	23	promyelocytic	promyelocytic	JJ
cord-350836-1enteev7	444	24	leukemia	leukemia	NN
cord-350836-1enteev7	444	25	cell	cell	NN
cord-350836-1enteev7	444	26	Retinoic	Retinoic	NNP
cord-350836-1enteev7	444	27	acid	acid	NN
cord-350836-1enteev7	444	28	-	-	HYPH
cord-350836-1enteev7	444	29	inducible	inducible	JJ
cord-350836-1enteev7	444	30	gene	gene	NN
cord-350836-1enteev7	444	31	-	-	:
cord-350836-1enteev7	444	32	I	-PRON-	PRP
cord-350836-1enteev7	444	33	is	be	VBZ
cord-350836-1enteev7	444	34	induced	induce	VBN
cord-350836-1enteev7	444	35	in	in	IN
cord-350836-1enteev7	444	36	endothelial	endothelial	JJ
cord-350836-1enteev7	444	37	cells	cell	NNS
cord-350836-1enteev7	444	38	by	by	IN
cord-350836-1enteev7	444	39	LPS	lp	NNS
cord-350836-1enteev7	444	40	and	and	CC
cord-350836-1enteev7	444	41	regulates	regulate	VBZ
cord-350836-1enteev7	444	42	expression	expression	NN
cord-350836-1enteev7	444	43	of	of	IN
cord-350836-1enteev7	445	1	COX-2	COX-2	NNP
cord-350836-1enteev7	445	2	mda-5	mda-5	NNP
cord-350836-1enteev7	445	3	:	:	:
cord-350836-1enteev7	445	4	an	an	DT
cord-350836-1enteev7	445	5	interferon	interferon	NN
cord-350836-1enteev7	445	6	-	-	HYPH
cord-350836-1enteev7	445	7	inducible	inducible	JJ
cord-350836-1enteev7	445	8	putative	putative	JJ
cord-350836-1enteev7	445	9	RNA	RNA	NNP
cord-350836-1enteev7	445	10	helicase	helicase	NN
cord-350836-1enteev7	445	11	with	with	IN
cord-350836-1enteev7	445	12	double	double	RB
cord-350836-1enteev7	445	13	-	-	HYPH
cord-350836-1enteev7	445	14	stranded	stranded	JJ
cord-350836-1enteev7	445	15	RNAdependent	rnadependent	NN
cord-350836-1enteev7	445	16	ATPase	ATPase	NNP
cord-350836-1enteev7	445	17	activity	activity	NN
cord-350836-1enteev7	445	18	and	and	CC
cord-350836-1enteev7	445	19	melanoma	melanoma	NN
cord-350836-1enteev7	445	20	growth	growth	NN
cord-350836-1enteev7	445	21	-	-	HYPH
cord-350836-1enteev7	445	22	suppressive	suppressive	JJ
cord-350836-1enteev7	445	23	properties	property	NNS
cord-350836-1enteev7	445	24	Overexpression	Overexpression	NNP
cord-350836-1enteev7	445	25	of	of	IN
cord-350836-1enteev7	445	26	helicard	helicard	NN
cord-350836-1enteev7	445	27	,	,	,
cord-350836-1enteev7	445	28	a	a	DT
cord-350836-1enteev7	445	29	CARD	card	NN
cord-350836-1enteev7	445	30	-	-	HYPH
cord-350836-1enteev7	445	31	containing	contain	VBG
cord-350836-1enteev7	445	32	helicase	helicase	NN
cord-350836-1enteev7	445	33	cleaved	cleave	VBN
cord-350836-1enteev7	445	34	during	during	IN
cord-350836-1enteev7	445	35	apoptosis	apoptosis	NN
cord-350836-1enteev7	445	36	,	,	,
cord-350836-1enteev7	445	37	accelerates	accelerate	VBZ
cord-350836-1enteev7	445	38	DNA	dna	NN
cord-350836-1enteev7	445	39	degradation	degradation	NN
cord-350836-1enteev7	445	40	Interferons	interferon	NNS
cord-350836-1enteev7	445	41	and	and	CC
cord-350836-1enteev7	445	42	viruses	virus	NNS
cord-350836-1enteev7	445	43	:	:	:
cord-350836-1enteev7	446	1	an	an	DT
cord-350836-1enteev7	446	2	interplay	interplay	NN
cord-350836-1enteev7	446	3	between	between	IN
cord-350836-1enteev7	446	4	induction	induction	NN
cord-350836-1enteev7	446	5	,	,	,
cord-350836-1enteev7	446	6	signalling	signal	VBG
cord-350836-1enteev7	446	7	,	,	,
cord-350836-1enteev7	446	8	antiviral	antiviral	JJ
cord-350836-1enteev7	446	9	responses	response	NNS
cord-350836-1enteev7	446	10	and	and	CC
cord-350836-1enteev7	446	11	virus	virus	NN
cord-350836-1enteev7	446	12	countermeasures	countermeasure	NNS
cord-350836-1enteev7	446	13	Mechanisms	Mechanisms	NNPS
cord-350836-1enteev7	446	14	of	of	IN
cord-350836-1enteev7	446	15	MAVS	MAVS	NNP
cord-350836-1enteev7	446	16	regulation	regulation	NN
cord-350836-1enteev7	446	17	at	at	IN
cord-350836-1enteev7	446	18	the	the	DT
cord-350836-1enteev7	446	19	mitochondrial	mitochondrial	JJ
cord-350836-1enteev7	446	20	membrane	membrane	NN
cord-350836-1enteev7	446	21	MAVS	MAVS	NNP
cord-350836-1enteev7	446	22	coordination	coordination	NN
cord-350836-1enteev7	446	23	of	of	IN
cord-350836-1enteev7	446	24	antiviral	antiviral	JJ
cord-350836-1enteev7	446	25	innate	innate	JJ
cord-350836-1enteev7	446	26	immunity	immunity	NN
cord-350836-1enteev7	446	27	Assembly	Assembly	NNP
cord-350836-1enteev7	446	28	of	of	IN
cord-350836-1enteev7	446	29	the	the	DT
cord-350836-1enteev7	446	30	WHIP	whip	NN
cord-350836-1enteev7	446	31	-	-	HYPH
cord-350836-1enteev7	446	32	TRIM14-PPP6C	trim14-ppp6c	NN
cord-350836-1enteev7	446	33	mitochondrial	mitochondrial	NN
cord-350836-1enteev7	446	34	complex	complex	NN
cord-350836-1enteev7	446	35	promotes	promote	VBZ
cord-350836-1enteev7	446	36	RIG	rig	NN
cord-350836-1enteev7	446	37	-	-	HYPH
cord-350836-1enteev7	446	38	I	i	NN
cord-350836-1enteev7	446	39	-	-	HYPH
cord-350836-1enteev7	446	40	mediated	mediate	VBN
cord-350836-1enteev7	446	41	antiviral	antiviral	JJ
cord-350836-1enteev7	446	42	signaling	signal	VBG
cord-350836-1enteev7	446	43	Zyxin	Zyxin	NNP
cord-350836-1enteev7	446	44	stabilizes	stabilize	VBZ
cord-350836-1enteev7	446	45	RIG	rig	NN
cord-350836-1enteev7	446	46	-	-	:
cord-350836-1enteev7	446	47	I	I	NNP
cord-350836-1enteev7	446	48	and	and	CC
cord-350836-1enteev7	446	49	MAVS	MAVS	NNP
cord-350836-1enteev7	446	50	interactions	interaction	NNS
cord-350836-1enteev7	446	51	and	and	CC
cord-350836-1enteev7	446	52	promotes	promote	VBZ
cord-350836-1enteev7	446	53	type	type	NN
cord-350836-1enteev7	446	54	I	-PRON-	PRP
cord-350836-1enteev7	446	55	interferon	interferon	VBD
cord-350836-1enteev7	446	56	response	response	NN
cord-350836-1enteev7	446	57	.	.	.
cord-350836-1enteev7	447	1	Sci	Sci	NNP
cord-350836-1enteev7	447	2	Rep	Rep	NNP
cord-350836-1enteev7	447	3	IKKε	IKKε	NNS
cord-350836-1enteev7	447	4	and	and	CC
cord-350836-1enteev7	447	5	TBK1	TBK1	NNP
cord-350836-1enteev7	447	6	are	be	VBP
cord-350836-1enteev7	447	7	essential	essential	JJ
cord-350836-1enteev7	447	8	components	component	NNS
cord-350836-1enteev7	447	9	of	of	IN
cord-350836-1enteev7	447	10	the	the	DT
cord-350836-1enteev7	447	11	IRF3	IRF3	NNP
cord-350836-1enteev7	447	12	signaling	signal	VBG
cord-350836-1enteev7	447	13	pathway	pathway	NN
cord-350836-1enteev7	447	14	Multiple	multiple	JJ
cord-350836-1enteev7	447	15	functions	function	NNS
cord-350836-1enteev7	447	16	of	of	IN
cord-350836-1enteev7	447	17	the	the	DT
cord-350836-1enteev7	447	18	IKK	IKK	NNP
cord-350836-1enteev7	447	19	-	-	HYPH
cord-350836-1enteev7	447	20	related	relate	VBN
cord-350836-1enteev7	447	21	kinase	kinase	NN
cord-350836-1enteev7	447	22	IKKe	IKKe	NNS
cord-350836-1enteev7	447	23	in	in	IN
cord-350836-1enteev7	447	24	interferon	interferon	NN
cord-350836-1enteev7	447	25	-	-	HYPH
cord-350836-1enteev7	447	26	mediated	mediate	VBN
cord-350836-1enteev7	447	27	antiviral	antiviral	JJ
cord-350836-1enteev7	447	28	immunity	immunity	NN
cord-350836-1enteev7	447	29	TRIM25	TRIM25	NNP
cord-350836-1enteev7	447	30	in	in	IN
cord-350836-1enteev7	447	31	the	the	DT
cord-350836-1enteev7	447	32	regulation	regulation	NN
cord-350836-1enteev7	447	33	of	of	IN
cord-350836-1enteev7	447	34	the	the	DT
cord-350836-1enteev7	447	35	antiviral	antiviral	JJ
cord-350836-1enteev7	447	36	innate	innate	JJ
cord-350836-1enteev7	447	37	immunity	immunity	NN
cord-350836-1enteev7	447	38	.	.	.
cord-350836-1enteev7	448	1	Front	Front	NNP
cord-350836-1enteev7	448	2	Immunol	Immunol	NNP
cord-350836-1enteev7	448	3	Molecular	Molecular	NNP
cord-350836-1enteev7	448	4	mechanisms	mechanism	NNS
cord-350836-1enteev7	448	5	of	of	IN
cord-350836-1enteev7	448	6	Dicer	dicer	NN
cord-350836-1enteev7	448	7	:	:	:
cord-350836-1enteev7	448	8	endonuclease	endonuclease	NN
cord-350836-1enteev7	448	9	and	and	CC
cord-350836-1enteev7	448	10	enzymatic	enzymatic	JJ
cord-350836-1enteev7	448	11	activity	activity	NN
cord-350836-1enteev7	449	1	The	the	DT
cord-350836-1enteev7	449	2	RIG	rig	NN
cord-350836-1enteev7	449	3	-	-	HYPH
cord-350836-1enteev7	449	4	I	i	NN
cord-350836-1enteev7	449	5	-	-	HYPH
cord-350836-1enteev7	449	6	like	like	JJ
cord-350836-1enteev7	449	7	receptor	receptor	NN
cord-350836-1enteev7	449	8	LGP2	LGP2	NNP
cord-350836-1enteev7	449	9	inhibits	inhibit	VBZ
cord-350836-1enteev7	449	10	Dicer	dicer	NN
cord-350836-1enteev7	449	11	-	-	HYPH
cord-350836-1enteev7	449	12	dependent	dependent	JJ
cord-350836-1enteev7	449	13	processing	processing	NN
cord-350836-1enteev7	449	14	of	of	IN
cord-350836-1enteev7	449	15	long	long	JJ
cord-350836-1enteev7	449	16	double	double	RB
cord-350836-1enteev7	449	17	-	-	HYPH
cord-350836-1enteev7	449	18	stranded	strand	VBN
cord-350836-1enteev7	449	19	RNA	RNA	NNP
cord-350836-1enteev7	449	20	and	and	CC
cord-350836-1enteev7	449	21	blocks	block	VBZ
cord-350836-1enteev7	449	22	RNA	RNA	NNP
cord-350836-1enteev7	449	23	interference	interference	NN
cord-350836-1enteev7	449	24	in	in	IN
cord-350836-1enteev7	449	25	mammalian	mammalian	JJ
cord-350836-1enteev7	449	26	cells	cell	NNS
cord-350836-1enteev7	449	27	Virus	virus	NN
cord-350836-1enteev7	449	28	sensor	sensor	NN
cord-350836-1enteev7	449	29	RIG	rig	NN
cord-350836-1enteev7	449	30	-	-	:
cord-350836-1enteev7	449	31	I	-PRON-	PRP
cord-350836-1enteev7	449	32	represses	repress	VBZ
cord-350836-1enteev7	449	33	RNA	RNA	NNP
cord-350836-1enteev7	449	34	interference	interference	NN
cord-350836-1enteev7	449	35	by	by	IN
cord-350836-1enteev7	449	36	interacting	interact	VBG
cord-350836-1enteev7	449	37	with	with	IN
cord-350836-1enteev7	449	38	TRBP	TRBP	NNP
cord-350836-1enteev7	449	39	through	through	IN
cord-350836-1enteev7	449	40	LGP2	LGP2	NNP
cord-350836-1enteev7	449	41	in	in	IN
cord-350836-1enteev7	449	42	mammalian	mammalian	JJ
cord-350836-1enteev7	449	43	cells	cell	NNS
cord-350836-1enteev7	449	44	LGP2	LGP2	NNP
cord-350836-1enteev7	450	1	:	:	:
cord-350836-1enteev7	450	2	positive	positive	JJ
cord-350836-1enteev7	450	3	about	about	IN
cord-350836-1enteev7	450	4	viral	viral	JJ
cord-350836-1enteev7	450	5	sensing	sensing	NN
cord-350836-1enteev7	450	6	MDA5	MDA5	NNP
cord-350836-1enteev7	450	7	and	and	CC
cord-350836-1enteev7	450	8	LGP2	LGP2	NNP
cord-350836-1enteev7	450	9	:	:	:
cord-350836-1enteev7	450	10	accomplices	accomplice	NNS
cord-350836-1enteev7	450	11	and	and	CC
cord-350836-1enteev7	450	12	antagonists	antagonist	NNS
cord-350836-1enteev7	450	13	of	of	IN
cord-350836-1enteev7	450	14	antiviral	antiviral	JJ
cord-350836-1enteev7	450	15	signal	signal	NN
cord-350836-1enteev7	450	16	transduction	transduction	NN
cord-350836-1enteev7	451	1	Negative	negative	JJ
cord-350836-1enteev7	451	2	regulators	regulator	NNS
cord-350836-1enteev7	451	3	of	of	IN
cord-350836-1enteev7	451	4	the	the	DT
cord-350836-1enteev7	451	5	RIG	rig	NN
cord-350836-1enteev7	451	6	-	-	HYPH
cord-350836-1enteev7	451	7	I	-PRON-	PRP
cord-350836-1enteev7	451	8	-	-	HYPH
cord-350836-1enteev7	451	9	like	like	JJ
cord-350836-1enteev7	451	10	receptor	receptor	NN
cord-350836-1enteev7	451	11	signaling	signal	VBG
cord-350836-1enteev7	451	12	pathway	pathway	NN
cord-350836-1enteev7	451	13	Tissue	tissue	NN
cord-350836-1enteev7	451	14	-	-	HYPH
cord-350836-1enteev7	451	15	based	base	VBN
cord-350836-1enteev7	451	16	map	map	NN
cord-350836-1enteev7	451	17	of	of	IN
cord-350836-1enteev7	451	18	the	the	DT
cord-350836-1enteev7	451	19	human	human	JJ
cord-350836-1enteev7	451	20	proteome	proteome	NN
cord-350836-1enteev7	451	21	Structural	structural	JJ
cord-350836-1enteev7	451	22	basis	basis	NN
cord-350836-1enteev7	451	23	for	for	IN
cord-350836-1enteev7	451	24	m7	m7	NN
cord-350836-1enteev7	451	25	G	g	NN
cord-350836-1enteev7	451	26	recognition	recognition	NN
cord-350836-1enteev7	451	27	and	and	CC
cord-350836-1enteev7	451	28	2'-O	2'-o	CD
cord-350836-1enteev7	451	29	-	-	HYPH
cord-350836-1enteev7	451	30	methyl	methyl	NN
cord-350836-1enteev7	451	31	discrimination	discrimination	NN
cord-350836-1enteev7	451	32	in	in	IN
cord-350836-1enteev7	451	33	capped	cap	VBN
cord-350836-1enteev7	451	34	RNAs	rna	NNS
cord-350836-1enteev7	451	35	by	by	IN
cord-350836-1enteev7	451	36	the	the	DT
cord-350836-1enteev7	451	37	innate	innate	JJ
cord-350836-1enteev7	451	38	immune	immune	JJ
cord-350836-1enteev7	451	39	receptor	receptor	NN
cord-350836-1enteev7	451	40	RIG	rig	NN
cord-350836-1enteev7	452	1	-I	-I	NFP
cord-350836-1enteev7	452	2	Structural	structural	JJ
cord-350836-1enteev7	452	3	basis	basis	NN
cord-350836-1enteev7	452	4	for	for	IN
cord-350836-1enteev7	452	5	dsRNA	dsrna	NN
cord-350836-1enteev7	452	6	recognition	recognition	NN
cord-350836-1enteev7	452	7	,	,	,
cord-350836-1enteev7	452	8	filament	filament	NN
cord-350836-1enteev7	452	9	formation	formation	NN
cord-350836-1enteev7	452	10	,	,	,
cord-350836-1enteev7	452	11	and	and	CC
cord-350836-1enteev7	452	12	antiviral	antiviral	JJ
cord-350836-1enteev7	452	13	signal	signal	NN
cord-350836-1enteev7	452	14	activation	activation	NN
cord-350836-1enteev7	452	15	by	by	IN
cord-350836-1enteev7	452	16	MDA5	MDA5	NNP
cord-350836-1enteev7	452	17	Molecular	Molecular	NNP
cord-350836-1enteev7	452	18	imprinting	imprinting	NN
cord-350836-1enteev7	452	19	as	as	IN
cord-350836-1enteev7	452	20	a	a	DT
cord-350836-1enteev7	452	21	signal	signal	NN
cord-350836-1enteev7	452	22	-	-	HYPH
cord-350836-1enteev7	452	23	activation	activation	NN
cord-350836-1enteev7	452	24	mechanism	mechanism	NN
cord-350836-1enteev7	452	25	of	of	IN
cord-350836-1enteev7	452	26	the	the	DT
cord-350836-1enteev7	452	27	viral	viral	JJ
cord-350836-1enteev7	452	28	RNA	RNA	NNP
cord-350836-1enteev7	452	29	sensor	sensor	NN
cord-350836-1enteev7	452	30	RIG	rig	NN
cord-350836-1enteev7	452	31	-	-	:
cord-350836-1enteev7	452	32	I	I	NNP
cord-350836-1enteev7	452	33	Parts	Parts	NNPS
cord-350836-1enteev7	452	34	,	,	,
cord-350836-1enteev7	452	35	assembly	assembly	NN
cord-350836-1enteev7	452	36	and	and	CC
cord-350836-1enteev7	452	37	operation	operation	NN
cord-350836-1enteev7	452	38	of	of	IN
cord-350836-1enteev7	452	39	the	the	DT
cord-350836-1enteev7	452	40	RIG	rig	NN
cord-350836-1enteev7	452	41	-	-	:
cord-350836-1enteev7	452	42	I	-PRON-	PRP
cord-350836-1enteev7	452	43	family	family	NN
cord-350836-1enteev7	452	44	of	of	IN
cord-350836-1enteev7	452	45	motors	motor	NNS
cord-350836-1enteev7	453	1	The	the	DT
cord-350836-1enteev7	453	2	RNA	RNA	NNP
cord-350836-1enteev7	453	3	helicase	helicase	NN
cord-350836-1enteev7	453	4	RIG	rig	NN
cord-350836-1enteev7	453	5	-	-	:
cord-350836-1enteev7	453	6	I	-PRON-	PRP
cord-350836-1enteev7	453	7	has	have	VBZ
cord-350836-1enteev7	453	8	an	an	DT
cord-350836-1enteev7	453	9	essential	essential	JJ
cord-350836-1enteev7	453	10	function	function	NN
cord-350836-1enteev7	453	11	in	in	IN
cord-350836-1enteev7	453	12	doublestranded	doublestranded	NNP
cord-350836-1enteev7	453	13	RNA	RNA	NNP
cord-350836-1enteev7	453	14	-	-	HYPH
cord-350836-1enteev7	453	15	induced	induce	VBN
cord-350836-1enteev7	453	16	innate	innate	JJ
cord-350836-1enteev7	453	17	antiviral	antiviral	JJ
cord-350836-1enteev7	453	18	responses	response	NNS
cord-350836-1enteev7	454	1	The	the	DT
cord-350836-1enteev7	454	2	C	c	NN
cord-350836-1enteev7	454	3	-	-	HYPH
cord-350836-1enteev7	454	4	terminal	terminal	NN
cord-350836-1enteev7	454	5	regulatory	regulatory	JJ
cord-350836-1enteev7	454	6	domain	domain	NN
cord-350836-1enteev7	454	7	is	be	VBZ
cord-350836-1enteev7	454	8	the	the	DT
cord-350836-1enteev7	454	9	RNA	RNA	NNP
cord-350836-1enteev7	454	10	5'-triphosphate	5'-triphosphate	CD
cord-350836-1enteev7	454	11	sensor	sensor	NN
cord-350836-1enteev7	454	12	of	of	IN
cord-350836-1enteev7	454	13	RIG	rig	NN
cord-350836-1enteev7	454	14	-	-	:
cord-350836-1enteev7	454	15	I	i	NN
cord-350836-1enteev7	455	1	5	5	LS
cord-350836-1enteev7	455	2	′	′	CD
cord-350836-1enteev7	456	1	-Triphosphate	-Triphosphate	NNP
cord-350836-1enteev7	456	2	RNA	RNA	NNP
cord-350836-1enteev7	456	3	is	be	VBZ
cord-350836-1enteev7	456	4	the	the	DT
cord-350836-1enteev7	456	5	ligand	ligand	NN
cord-350836-1enteev7	456	6	for	for	IN
cord-350836-1enteev7	456	7	RIG	rig	NN
cord-350836-1enteev7	456	8	-	-	:
cord-350836-1enteev7	456	9	I	I	NNP
cord-350836-1enteev7	456	10	RIG	rig	NN
cord-350836-1enteev7	456	11	-	-	:
cord-350836-1enteev7	456	12	I	i	NN
cord-350836-1enteev7	456	13	-	-	HYPH
cord-350836-1enteev7	456	14	mediated	mediate	VBN
cord-350836-1enteev7	456	15	antiviral	antiviral	JJ
cord-350836-1enteev7	456	16	responses	response	NNS
cord-350836-1enteev7	456	17	to	to	IN
cord-350836-1enteev7	456	18	single	single	RB
cord-350836-1enteev7	456	19	-	-	HYPH
cord-350836-1enteev7	456	20	stranded	strand	VBN
cord-350836-1enteev7	456	21	RNA	RNA	NNP
cord-350836-1enteev7	456	22	bearing	bear	VBG
cord-350836-1enteev7	456	23	5'-Phosphates	5'-phosphates	CD
cord-350836-1enteev7	457	1	Nonself	Nonself	NNP
cord-350836-1enteev7	457	2	RNA	RNA	NNP
cord-350836-1enteev7	457	3	-	-	HYPH
cord-350836-1enteev7	457	4	sensing	sense	VBG
cord-350836-1enteev7	457	5	mechanism	mechanism	NN
cord-350836-1enteev7	457	6	of	of	IN
cord-350836-1enteev7	457	7	RIG-	RIG-	NNP
cord-350836-1enteev7	458	1	I	-PRON-	PRP
cord-350836-1enteev7	458	2	helicase	helicase	VBD
cord-350836-1enteev7	458	3	and	and	CC
cord-350836-1enteev7	458	4	activation	activation	NN
cord-350836-1enteev7	458	5	of	of	IN
cord-350836-1enteev7	458	6	antiviral	antiviral	JJ
cord-350836-1enteev7	458	7	immune	immune	JJ
cord-350836-1enteev7	458	8	responses	response	NNS
cord-350836-1enteev7	459	1	Cytosolic	cytosolic	JJ
cord-350836-1enteev7	459	2	viral	viral	JJ
cord-350836-1enteev7	459	3	sensor	sensor	NN
cord-350836-1enteev7	459	4	RIG	rig	NN
cord-350836-1enteev7	459	5	-	-	:
cord-350836-1enteev7	459	6	I	-PRON-	PRP
cord-350836-1enteev7	459	7	is	be	VBZ
cord-350836-1enteev7	459	8	a	a	DT
cord-350836-1enteev7	459	9	5'-Triphosphate	5'-triphosphate	JJ
cord-350836-1enteev7	459	10	-	-	HYPH
cord-350836-1enteev7	459	11	dependent	dependent	JJ
cord-350836-1enteev7	459	12	translocase	translocase	NN
cord-350836-1enteev7	459	13	on	on	IN
cord-350836-1enteev7	459	14	doublestranded	doublestranded	NNP
cord-350836-1enteev7	459	15	RNA	RNA	NNP
cord-350836-1enteev7	460	1	The	the	DT
cord-350836-1enteev7	460	2	structural	structural	JJ
cord-350836-1enteev7	460	3	basis	basis	NN
cord-350836-1enteev7	460	4	of	of	IN
cord-350836-1enteev7	460	5	5	5	CD
cord-350836-1enteev7	460	6	'	'	''
cord-350836-1enteev7	460	7	triphosphate	triphosphate	NN
cord-350836-1enteev7	460	8	double	double	RB
cord-350836-1enteev7	460	9	-	-	HYPH
cord-350836-1enteev7	460	10	stranded	strand	VBN
cord-350836-1enteev7	460	11	RNA	rna	NN
cord-350836-1enteev7	460	12	recognition	recognition	NN
cord-350836-1enteev7	460	13	by	by	IN
cord-350836-1enteev7	460	14	RIG	rig	NN
cord-350836-1enteev7	460	15	-	-	:
cord-350836-1enteev7	460	16	I	I	NNP
cord-350836-1enteev7	460	17	C	c	NN
cord-350836-1enteev7	460	18	-	-	HYPH
cord-350836-1enteev7	460	19	terminal	terminal	NN
cord-350836-1enteev7	460	20	domain	domain	NN
cord-350836-1enteev7	460	21	RIG	rig	NN
cord-350836-1enteev7	461	1	-I	-I	NNP
cord-350836-1enteev7	461	2	detects	detect	VBZ
cord-350836-1enteev7	461	3	viral	viral	JJ
cord-350836-1enteev7	461	4	genomic	genomic	JJ
cord-350836-1enteev7	461	5	RNA	RNA	NNP
cord-350836-1enteev7	461	6	during	during	IN
cord-350836-1enteev7	461	7	negative	negative	JJ
cord-350836-1enteev7	461	8	-	-	HYPH
cord-350836-1enteev7	461	9	strand	strand	NN
cord-350836-1enteev7	461	10	RNA	RNA	NNP
cord-350836-1enteev7	461	11	virus	virus	NN
cord-350836-1enteev7	461	12	infection	infection	NN
cord-350836-1enteev7	461	13	Structural	structural	JJ
cord-350836-1enteev7	461	14	and	and	CC
cord-350836-1enteev7	461	15	functional	functional	JJ
cord-350836-1enteev7	461	16	insights	insight	NNS
cord-350836-1enteev7	461	17	into	into	IN
cord-350836-1enteev7	461	18	5'-ppp	5'-ppp	CD
cord-350836-1enteev7	461	19	RNA	RNA	NNP
cord-350836-1enteev7	461	20	pattern	pattern	NN
cord-350836-1enteev7	461	21	recognition	recognition	NN
cord-350836-1enteev7	461	22	by	by	IN
cord-350836-1enteev7	461	23	the	the	DT
cord-350836-1enteev7	461	24	innate	innate	JJ
cord-350836-1enteev7	461	25	immune	immune	JJ
cord-350836-1enteev7	461	26	receptor	receptor	NN
cord-350836-1enteev7	461	27	RIG-	rig-	NN
cord-350836-1enteev7	462	1	I	-PRON-	PRP
cord-350836-1enteev7	463	1	The	the	DT
cord-350836-1enteev7	463	2	thermodynamic	thermodynamic	JJ
cord-350836-1enteev7	463	3	basis	basis	NN
cord-350836-1enteev7	463	4	for	for	IN
cord-350836-1enteev7	463	5	viral	viral	JJ
cord-350836-1enteev7	463	6	RNA	RNA	NNP
cord-350836-1enteev7	463	7	detection	detection	NN
cord-350836-1enteev7	463	8	by	by	IN
cord-350836-1enteev7	463	9	the	the	DT
cord-350836-1enteev7	463	10	RIG	rig	NN
cord-350836-1enteev7	463	11	-	-	:
cord-350836-1enteev7	463	12	I	-PRON-	PRP
cord-350836-1enteev7	463	13	innate	innate	VBP
cord-350836-1enteev7	463	14	immune	immune	JJ
cord-350836-1enteev7	463	15	sensor	sensor	NN
cord-350836-1enteev7	463	16	RIG	rig	NN
cord-350836-1enteev7	464	1	-I	-i	DT
cord-350836-1enteev7	464	2	ATPase	ATPase	NNP
cord-350836-1enteev7	464	3	activity	activity	NN
cord-350836-1enteev7	464	4	and	and	CC
cord-350836-1enteev7	464	5	discrimination	discrimination	NN
cord-350836-1enteev7	464	6	of	of	IN
cord-350836-1enteev7	464	7	self	self	NN
cord-350836-1enteev7	464	8	-	-	HYPH
cord-350836-1enteev7	464	9	RNA	RNA	NNP
cord-350836-1enteev7	464	10	versus	versus	IN
cord-350836-1enteev7	464	11	non	non	JJ
cord-350836-1enteev7	464	12	-	-	JJ
cord-350836-1enteev7	464	13	self	self	JJ
cord-350836-1enteev7	464	14	-	-	HYPH
cord-350836-1enteev7	464	15	RNA	RNA	NNP
cord-350836-1enteev7	464	16	Length	length	NN
cord-350836-1enteev7	464	17	-	-	HYPH
cord-350836-1enteev7	464	18	dependent	dependent	JJ
cord-350836-1enteev7	464	19	recognition	recognition	NN
cord-350836-1enteev7	464	20	of	of	IN
cord-350836-1enteev7	464	21	doublestranded	doublestranded	JJ
cord-350836-1enteev7	464	22	ribonucleic	ribonucleic	JJ
cord-350836-1enteev7	464	23	acids	acid	NNS
cord-350836-1enteev7	464	24	by	by	IN
cord-350836-1enteev7	464	25	retinoic	retinoic	JJ
cord-350836-1enteev7	464	26	acid	acid	NN
cord-350836-1enteev7	464	27	-inducible	-inducible	JJ
cord-350836-1enteev7	464	28	gene	gene	NN
cord-350836-1enteev7	464	29	-	-	:
cord-350836-1enteev7	464	30	I	i	NN
cord-350836-1enteev7	464	31	and	and	CC
cord-350836-1enteev7	464	32	melanoma	melanoma	NN
cord-350836-1enteev7	464	33	differentiation	differentiation	NN
cord-350836-1enteev7	465	1	-associated	-associated	JJ
cord-350836-1enteev7	465	2	gene	gene	NN
cord-350836-1enteev7	465	3	5	5	CD
cord-350836-1enteev7	465	4	Activation	activation	NN
cord-350836-1enteev7	465	5	of	of	IN
cord-350836-1enteev7	465	6	MDA5	MDA5	NNP
cord-350836-1enteev7	465	7	requires	require	VBZ
cord-350836-1enteev7	465	8	higher	high	JJR
cord-350836-1enteev7	465	9	-	-	HYPH
cord-350836-1enteev7	465	10	order	order	NN
cord-350836-1enteev7	465	11	RNA	RNA	NNP
cord-350836-1enteev7	465	12	structures	structure	NNS
cord-350836-1enteev7	465	13	generated	generate	VBN
cord-350836-1enteev7	465	14	during	during	IN
cord-350836-1enteev7	465	15	virus	virus	NN
cord-350836-1enteev7	465	16	infection	infection	NN
cord-350836-1enteev7	465	17	MDA5	MDA5	NNP
cord-350836-1enteev7	465	18	detects	detect	VBZ
cord-350836-1enteev7	465	19	the	the	DT
cord-350836-1enteev7	465	20	double	double	RB
cord-350836-1enteev7	465	21	-	-	HYPH
cord-350836-1enteev7	465	22	stranded	strand	VBN
cord-350836-1enteev7	465	23	RNA	RNA	NNP
cord-350836-1enteev7	465	24	replicative	replicative	JJ
cord-350836-1enteev7	465	25	form	form	NN
cord-350836-1enteev7	465	26	in	in	IN
cord-350836-1enteev7	465	27	picornavirusinfected	picornavirusinfected	JJ
cord-350836-1enteev7	465	28	cells	cell	NNS
cord-350836-1enteev7	465	29	Visualisation	visualisation	NN
cord-350836-1enteev7	465	30	of	of	IN
cord-350836-1enteev7	465	31	direct	direct	JJ
cord-350836-1enteev7	465	32	interaction	interaction	NN
cord-350836-1enteev7	465	33	of	of	IN
cord-350836-1enteev7	465	34	MDA5	MDA5	NNP
cord-350836-1enteev7	465	35	and	and	CC
cord-350836-1enteev7	465	36	the	the	DT
cord-350836-1enteev7	465	37	dsRNA	dsrna	NN
cord-350836-1enteev7	465	38	replicative	replicative	JJ
cord-350836-1enteev7	465	39	intermediate	intermediate	JJ
cord-350836-1enteev7	465	40	form	form	NN
cord-350836-1enteev7	465	41	of	of	IN
cord-350836-1enteev7	465	42	positive	positive	JJ
cord-350836-1enteev7	465	43	strand	strand	NN
cord-350836-1enteev7	465	44	RNA	rna	NN
cord-350836-1enteev7	465	45	viruses	virus	NNS
cord-350836-1enteev7	466	1	A	a	DT
cord-350836-1enteev7	466	2	structure	structure	NN
cord-350836-1enteev7	466	3	-	-	HYPH
cord-350836-1enteev7	466	4	based	base	VBN
cord-350836-1enteev7	466	5	model	model	NN
cord-350836-1enteev7	466	6	of	of	IN
cord-350836-1enteev7	466	7	RIG	rig	NN
cord-350836-1enteev7	466	8	-	-	:
cord-350836-1enteev7	466	9	I	-PRON-	PRP
cord-350836-1enteev7	466	10	activation	activation	VBP
cord-350836-1enteev7	466	11	Toward	toward	IN
cord-350836-1enteev7	466	12	a	a	DT
cord-350836-1enteev7	466	13	crystal	crystal	JJ
cord-350836-1enteev7	466	14	-	-	HYPH
cord-350836-1enteev7	466	15	clear	clear	JJ
cord-350836-1enteev7	466	16	view	view	NN
cord-350836-1enteev7	466	17	of	of	IN
cord-350836-1enteev7	466	18	the	the	DT
cord-350836-1enteev7	466	19	viral	viral	JJ
cord-350836-1enteev7	466	20	RNA	RNA	NNP
cord-350836-1enteev7	466	21	sensing	sensing	NN
cord-350836-1enteev7	466	22	and	and	CC
cord-350836-1enteev7	466	23	response	response	NN
cord-350836-1enteev7	466	24	by	by	IN
cord-350836-1enteev7	466	25	RIG	rig	NN
cord-350836-1enteev7	466	26	-	-	HYPH
cord-350836-1enteev7	466	27	I	i	NN
cord-350836-1enteev7	466	28	-	-	HYPH
cord-350836-1enteev7	466	29	like	like	JJ
cord-350836-1enteev7	466	30	receptors	receptor	NNS
cord-350836-1enteev7	466	31	Pattern	pattern	NN
cord-350836-1enteev7	466	32	recognition	recognition	NN
cord-350836-1enteev7	466	33	and	and	CC
cord-350836-1enteev7	466	34	signaling	signal	VBG
cord-350836-1enteev7	466	35	mechanisms	mechanism	NNS
cord-350836-1enteev7	466	36	of	of	IN
cord-350836-1enteev7	466	37	RIG	rig	NN
cord-350836-1enteev7	466	38	-	-	:
cord-350836-1enteev7	466	39	I	I	NNP
cord-350836-1enteev7	466	40	and	and	CC
cord-350836-1enteev7	466	41	MDA5	MDA5	NNP
cord-350836-1enteev7	466	42	Antiviral	Antiviral	NNP
cord-350836-1enteev7	466	43	RNA	RNA	NNP
cord-350836-1enteev7	466	44	recognition	recognition	NN
cord-350836-1enteev7	466	45	and	and	CC
cord-350836-1enteev7	466	46	assembly	assembly	NN
cord-350836-1enteev7	466	47	by	by	IN
cord-350836-1enteev7	466	48	RLR	RLR	NNP
cord-350836-1enteev7	466	49	family	family	NN
cord-350836-1enteev7	466	50	innate	innate	VBP
cord-350836-1enteev7	466	51	immune	immune	JJ
cord-350836-1enteev7	466	52	sensors	sensor	NNS
cord-350836-1enteev7	467	1	Post	post	JJ
cord-350836-1enteev7	467	2	-	-	JJ
cord-350836-1enteev7	467	3	translational	translational	JJ
cord-350836-1enteev7	467	4	control	control	NN
cord-350836-1enteev7	467	5	of	of	IN
cord-350836-1enteev7	467	6	intracellular	intracellular	JJ
cord-350836-1enteev7	467	7	pathogen	pathogen	NN
cord-350836-1enteev7	467	8	sensing	sensing	NN
cord-350836-1enteev7	467	9	pathways	pathway	NNS
cord-350836-1enteev7	467	10	Essential	essential	JJ
cord-350836-1enteev7	467	11	role	role	NN
cord-350836-1enteev7	467	12	of	of	IN
cord-350836-1enteev7	467	13	the	the	DT
cord-350836-1enteev7	467	14	N	n	CD
cord-350836-1enteev7	467	15	-	-	HYPH
cord-350836-1enteev7	467	16	terminal	terminal	NN
cord-350836-1enteev7	467	17	domain	domain	NN
cord-350836-1enteev7	467	18	in	in	IN
cord-350836-1enteev7	467	19	the	the	DT
cord-350836-1enteev7	467	20	regulation	regulation	NN
cord-350836-1enteev7	467	21	of	of	IN
cord-350836-1enteev7	467	22	RIG	rig	NN
cord-350836-1enteev7	467	23	-	-	:
cord-350836-1enteev7	467	24	I	-PRON-	PRP
cord-350836-1enteev7	467	25	ATPase	ATPase	NNP
cord-350836-1enteev7	467	26	activity	activity	NN
cord-350836-1enteev7	467	27	Structural	structural	JJ
cord-350836-1enteev7	467	28	basis	basis	NN
cord-350836-1enteev7	467	29	for	for	IN
cord-350836-1enteev7	467	30	the	the	DT
cord-350836-1enteev7	467	31	activation	activation	NN
cord-350836-1enteev7	467	32	of	of	IN
cord-350836-1enteev7	467	33	innate	innate	JJ
cord-350836-1enteev7	467	34	immune	immune	JJ
cord-350836-1enteev7	467	35	pattern	pattern	NN
cord-350836-1enteev7	467	36	-	-	HYPH
cord-350836-1enteev7	467	37	recognition	recognition	NN
cord-350836-1enteev7	467	38	receptor	receptor	NN
cord-350836-1enteev7	467	39	RIG	rig	NN
cord-350836-1enteev7	467	40	-	-	:
cord-350836-1enteev7	467	41	I	i	NN
cord-350836-1enteev7	467	42	by	by	IN
cord-350836-1enteev7	467	43	viral	viral	JJ
cord-350836-1enteev7	467	44	RNA	RNA	NNP
cord-350836-1enteev7	467	45	Structural	Structural	NNP
cord-350836-1enteev7	467	46	and	and	CC
cord-350836-1enteev7	467	47	biochemical	biochemical	JJ
cord-350836-1enteev7	467	48	studies	study	NNS
cord-350836-1enteev7	467	49	of	of	IN
cord-350836-1enteev7	467	50	RIG	rig	NN
cord-350836-1enteev7	467	51	-	-	:
cord-350836-1enteev7	467	52	I	i	NN
cord-350836-1enteev7	468	1	antiviral	antiviral	JJ
cord-350836-1enteev7	468	2	signaling	signal	VBG
cord-350836-1enteev7	468	3	Negative	negative	JJ
cord-350836-1enteev7	468	4	role	role	NN
cord-350836-1enteev7	468	5	of	of	IN
cord-350836-1enteev7	468	6	RIG	rig	NN
cord-350836-1enteev7	468	7	-	-	:
cord-350836-1enteev7	468	8	I	i	NN
cord-350836-1enteev7	468	9	serine	serine	NN
cord-350836-1enteev7	468	10	8	8	CD
cord-350836-1enteev7	468	11	phosphorylation	phosphorylation	NN
cord-350836-1enteev7	468	12	in	in	IN
cord-350836-1enteev7	468	13	the	the	DT
cord-350836-1enteev7	468	14	regulation	regulation	NN
cord-350836-1enteev7	468	15	of	of	IN
cord-350836-1enteev7	468	16	interferon	interferon	NN
cord-350836-1enteev7	468	17	-	-	HYPH
cord-350836-1enteev7	468	18	beta	beta	NN
cord-350836-1enteev7	468	19	production	production	NN
cord-350836-1enteev7	468	20	Conventional	Conventional	NNP
cord-350836-1enteev7	468	21	protein	protein	NN
cord-350836-1enteev7	469	1	kinase	kinase	NNP
cord-350836-1enteev7	469	2	C	C	NNP
cord-350836-1enteev7	469	3	-	-	HYPH
cord-350836-1enteev7	469	4	α	α	NNP
cord-350836-1enteev7	469	5	(	(	-LRB-
cord-350836-1enteev7	469	6	PKC	PKC	NNP
cord-350836-1enteev7	469	7	-	-	HYPH
cord-350836-1enteev7	469	8	α	α	NNP
cord-350836-1enteev7	469	9	)	)	-RRB-
cord-350836-1enteev7	469	10	and	and	CC
cord-350836-1enteev7	469	11	PKC	PKC	NNP
cord-350836-1enteev7	469	12	-	-	HYPH
cord-350836-1enteev7	469	13	β	β	NNP
cord-350836-1enteev7	469	14	negatively	negatively	RB
cord-350836-1enteev7	469	15	regulate	regulate	VBP
cord-350836-1enteev7	469	16	RIG	rig	NN
cord-350836-1enteev7	469	17	-	-	:
cord-350836-1enteev7	469	18	I	-PRON-	PRP
cord-350836-1enteev7	469	19	antiviral	antiviral	JJ
cord-350836-1enteev7	469	20	signal	signal	NN
cord-350836-1enteev7	469	21	transduction	transduction	NN
cord-350836-1enteev7	469	22	Phosphorylation	Phosphorylation	NNP
cord-350836-1enteev7	469	23	of	of	IN
cord-350836-1enteev7	469	24	RIG	rig	NN
cord-350836-1enteev7	469	25	-	-	:
cord-350836-1enteev7	469	26	I	-PRON-	PRP
cord-350836-1enteev7	469	27	by	by	IN
cord-350836-1enteev7	469	28	casein	casein	NN
cord-350836-1enteev7	469	29	kinase	kinase	NNP
cord-350836-1enteev7	469	30	II	II	NNP
cord-350836-1enteev7	469	31	inhibits	inhibit	VBZ
cord-350836-1enteev7	469	32	its	-PRON-	PRP$
cord-350836-1enteev7	469	33	antiviral	antiviral	JJ
cord-350836-1enteev7	469	34	response	response	NN
cord-350836-1enteev7	469	35	RIOK3-mediated	riok3-mediate	VBN
cord-350836-1enteev7	469	36	phosphorylation	phosphorylation	NN
cord-350836-1enteev7	469	37	of	of	IN
cord-350836-1enteev7	469	38	MDA5	MDA5	NNP
cord-350836-1enteev7	469	39	interferes	interfere	VBZ
cord-350836-1enteev7	469	40	with	with	IN
cord-350836-1enteev7	469	41	its	-PRON-	PRP$
cord-350836-1enteev7	469	42	assembly	assembly	NN
cord-350836-1enteev7	469	43	and	and	CC
cord-350836-1enteev7	469	44	attenuates	attenuate	VBZ
cord-350836-1enteev7	469	45	the	the	DT
cord-350836-1enteev7	469	46	innate	innate	JJ
cord-350836-1enteev7	469	47	immune	immune	JJ
cord-350836-1enteev7	469	48	response	response	NN
cord-350836-1enteev7	469	49	Dephosphorylation	dephosphorylation	NN
cord-350836-1enteev7	469	50	of	of	IN
cord-350836-1enteev7	469	51	the	the	DT
cord-350836-1enteev7	469	52	RNA	RNA	NNP
cord-350836-1enteev7	469	53	sensors	sensor	NNS
cord-350836-1enteev7	469	54	RIG	rig	NN
cord-350836-1enteev7	469	55	-	-	:
cord-350836-1enteev7	469	56	I	I	NNP
cord-350836-1enteev7	469	57	and	and	CC
cord-350836-1enteev7	469	58	MDA5	MDA5	NNP
cord-350836-1enteev7	469	59	by	by	IN
cord-350836-1enteev7	469	60	the	the	DT
cord-350836-1enteev7	469	61	phosphatase	phosphatase	NN
cord-350836-1enteev7	469	62	PP1	PP1	NNP
cord-350836-1enteev7	469	63	is	be	VBZ
cord-350836-1enteev7	469	64	essential	essential	JJ
cord-350836-1enteev7	469	65	for	for	IN
cord-350836-1enteev7	469	66	innate	innate	JJ
cord-350836-1enteev7	469	67	immune	immune	NN
cord-350836-1enteev7	469	68	signaling	signal	VBG
cord-350836-1enteev7	469	69	Antagonism	antagonism	NN
cord-350836-1enteev7	469	70	of	of	IN
cord-350836-1enteev7	469	71	the	the	DT
cord-350836-1enteev7	469	72	phosphatase	phosphatase	NN
cord-350836-1enteev7	469	73	PP1	PP1	NNP
cord-350836-1enteev7	469	74	by	by	IN
cord-350836-1enteev7	469	75	the	the	DT
cord-350836-1enteev7	469	76	measles	measle	NNS
cord-350836-1enteev7	469	77	virus	virus	NN
cord-350836-1enteev7	469	78	V	v	NN
cord-350836-1enteev7	469	79	protein	protein	NN
cord-350836-1enteev7	469	80	is	be	VBZ
cord-350836-1enteev7	469	81	required	require	VBN
cord-350836-1enteev7	469	82	for	for	IN
cord-350836-1enteev7	469	83	innate	innate	JJ
cord-350836-1enteev7	469	84	immune	immune	JJ
cord-350836-1enteev7	469	85	escape	escape	NN
cord-350836-1enteev7	469	86	of	of	IN
cord-350836-1enteev7	469	87	MDA5	mda5	JJ
cord-350836-1enteev7	469	88	HDAC6	HDAC6	NNS
cord-350836-1enteev7	469	89	regulates	regulate	VBZ
cord-350836-1enteev7	469	90	cellular	cellular	JJ
cord-350836-1enteev7	469	91	viral	viral	JJ
cord-350836-1enteev7	469	92	RNA	RNA	NNP
cord-350836-1enteev7	469	93	sensing	sensing	NN
cord-350836-1enteev7	469	94	by	by	IN
cord-350836-1enteev7	469	95	deacetylation	deacetylation	NN
cord-350836-1enteev7	469	96	of	of	IN
cord-350836-1enteev7	469	97	RIG-	RIG-	NNP
cord-350836-1enteev7	470	1	I	-PRON-	PRP
cord-350836-1enteev7	471	1	The	the	DT
cord-350836-1enteev7	471	2	mechanism	mechanism	NN
cord-350836-1enteev7	471	3	of	of	IN
cord-350836-1enteev7	471	4	ATP	ATP	NNP
cord-350836-1enteev7	471	5	-	-	HYPH
cord-350836-1enteev7	471	6	dependent	dependent	JJ
cord-350836-1enteev7	471	7	RNA	RNA	NNP
cord-350836-1enteev7	471	8	unwinding	unwind	VBG
cord-350836-1enteev7	471	9	by	by	IN
cord-350836-1enteev7	471	10	DEAD	dead	JJ
cord-350836-1enteev7	471	11	box	box	NN
cord-350836-1enteev7	471	12	proteins	protein	NNS
cord-350836-1enteev7	471	13	Mechanisms	Mechanisms	NNPS
cord-350836-1enteev7	471	14	of	of	IN
cord-350836-1enteev7	471	15	RIG	rig	NN
cord-350836-1enteev7	471	16	-	-	HYPH
cord-350836-1enteev7	471	17	I	i	NN
cord-350836-1enteev7	471	18	-	-	HYPH
cord-350836-1enteev7	471	19	like	like	JJ
cord-350836-1enteev7	471	20	receptor	receptor	NN
cord-350836-1enteev7	471	21	activation	activation	NN
cord-350836-1enteev7	471	22	and	and	CC
cord-350836-1enteev7	471	23	manipulation	manipulation	NN
cord-350836-1enteev7	471	24	by	by	IN
cord-350836-1enteev7	471	25	viral	viral	JJ
cord-350836-1enteev7	471	26	pathogens	pathogen	NNS
cord-350836-1enteev7	472	1	The	the	DT
cord-350836-1enteev7	472	2	catcher	catcher	NN
cord-350836-1enteev7	472	3	in	in	IN
cord-350836-1enteev7	472	4	the	the	DT
cord-350836-1enteev7	472	5	RIG	rig	NN
cord-350836-1enteev7	472	6	-	-	:
cord-350836-1enteev7	472	7	I	I	NNP
cord-350836-1enteev7	472	8	Viral	Viral	NNP
cord-350836-1enteev7	472	9	RNA	RNA	NNP
cord-350836-1enteev7	472	10	detection	detection	NN
cord-350836-1enteev7	472	11	by	by	IN
cord-350836-1enteev7	472	12	RIG	rig	NN
cord-350836-1enteev7	472	13	-	-	HYPH
cord-350836-1enteev7	472	14	I	i	NN
cord-350836-1enteev7	472	15	-	-	HYPH
cord-350836-1enteev7	472	16	like	like	JJ
cord-350836-1enteev7	472	17	receptors	receptor	NNS
cord-350836-1enteev7	472	18	MDA5	MDA5	VBN
cord-350836-1enteev7	472	19	cooperatively	cooperatively	RB
cord-350836-1enteev7	472	20	forms	form	VBZ
cord-350836-1enteev7	472	21	dimers	dimer	NNS
cord-350836-1enteev7	472	22	and	and	CC
cord-350836-1enteev7	472	23	ATP	ATP	NNP
cord-350836-1enteev7	472	24	-	-	HYPH
cord-350836-1enteev7	472	25	sensitive	sensitive	JJ
cord-350836-1enteev7	472	26	filaments	filament	NNS
cord-350836-1enteev7	472	27	upon	upon	IN
cord-350836-1enteev7	472	28	binding	bind	VBG
cord-350836-1enteev7	472	29	double	double	RB
cord-350836-1enteev7	472	30	-	-	HYPH
cord-350836-1enteev7	472	31	stranded	strand	VBN
cord-350836-1enteev7	472	32	RNA	RNA	NNP
cord-350836-1enteev7	472	33	Riplet	Riplet	NNP
cord-350836-1enteev7	472	34	/	/	SYM
cord-350836-1enteev7	472	35	RNF135	RNF135	NNPS
cord-350836-1enteev7	472	36	,	,	,
cord-350836-1enteev7	472	37	a	a	DT
cord-350836-1enteev7	472	38	RING	ring	NN
cord-350836-1enteev7	472	39	finger	finger	NN
cord-350836-1enteev7	472	40	protein	protein	NN
cord-350836-1enteev7	472	41	,	,	,
cord-350836-1enteev7	472	42	ubiquitinates	ubiquitinates	NNP
cord-350836-1enteev7	472	43	RIG	RIG	NNP
cord-350836-1enteev7	472	44	-	-	:
cord-350836-1enteev7	472	45	I	-PRON-	PRP
cord-350836-1enteev7	472	46	to	to	TO
cord-350836-1enteev7	472	47	promote	promote	VB
cord-350836-1enteev7	472	48	interferon	interferon	NN
cord-350836-1enteev7	472	49	-	-	HYPH
cord-350836-1enteev7	472	50	beta	beta	NN
cord-350836-1enteev7	472	51	induction	induction	NN
cord-350836-1enteev7	472	52	during	during	IN
cord-350836-1enteev7	472	53	the	the	DT
cord-350836-1enteev7	472	54	early	early	JJ
cord-350836-1enteev7	472	55	phase	phase	NN
cord-350836-1enteev7	472	56	of	of	IN
cord-350836-1enteev7	472	57	viral	viral	JJ
cord-350836-1enteev7	472	58	infection	infection	NN
cord-350836-1enteev7	473	1	REUL	REUL	NNP
cord-350836-1enteev7	473	2	is	be	VBZ
cord-350836-1enteev7	473	3	a	a	DT
cord-350836-1enteev7	473	4	novel	novel	JJ
cord-350836-1enteev7	473	5	E3	e3	NN
cord-350836-1enteev7	473	6	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	473	7	ligase	ligase	NN
cord-350836-1enteev7	473	8	and	and	CC
cord-350836-1enteev7	473	9	stimulator	stimulator	NN
cord-350836-1enteev7	473	10	of	of	IN
cord-350836-1enteev7	473	11	retinoic	retinoic	JJ
cord-350836-1enteev7	473	12	-	-	HYPH
cord-350836-1enteev7	473	13	acid	acid	NN
cord-350836-1enteev7	473	14	-	-	HYPH
cord-350836-1enteev7	473	15	inducible	inducible	JJ
cord-350836-1enteev7	473	16	gene-	gene-	NN
cord-350836-1enteev7	474	1	I	-PRON-	PRP
cord-350836-1enteev7	475	1	A	a	DT
cord-350836-1enteev7	475	2	distinct	distinct	JJ
cord-350836-1enteev7	475	3	role	role	NN
cord-350836-1enteev7	475	4	of	of	IN
cord-350836-1enteev7	475	5	Riplet	Riplet	NNP
cord-350836-1enteev7	475	6	-	-	HYPH
cord-350836-1enteev7	475	7	mediated	mediate	VBN
cord-350836-1enteev7	475	8	K63-Linked	k63-linke	VBN
cord-350836-1enteev7	475	9	polyubiquitination	polyubiquitination	NN
cord-350836-1enteev7	475	10	of	of	IN
cord-350836-1enteev7	475	11	the	the	DT
cord-350836-1enteev7	475	12	RIG	rig	NN
cord-350836-1enteev7	475	13	-	-	:
cord-350836-1enteev7	475	14	I	i	NN
cord-350836-1enteev7	475	15	repressor	repressor	NN
cord-350836-1enteev7	475	16	domain	domain	NN
cord-350836-1enteev7	475	17	in	in	IN
cord-350836-1enteev7	475	18	human	human	JJ
cord-350836-1enteev7	475	19	antiviral	antiviral	JJ
cord-350836-1enteev7	475	20	innate	innate	JJ
cord-350836-1enteev7	475	21	immune	immune	JJ
cord-350836-1enteev7	475	22	responses	response	NNS
cord-350836-1enteev7	475	23	Ubiquitindependent	Ubiquitindependent	NNP
cord-350836-1enteev7	475	24	and	and	CC
cord-350836-1enteev7	475	25	-independent	-independent	JJ
cord-350836-1enteev7	475	26	roles	role	NNS
cord-350836-1enteev7	475	27	of	of	IN
cord-350836-1enteev7	475	28	E3	e3	NN
cord-350836-1enteev7	475	29	ligase	ligase	NN
cord-350836-1enteev7	475	30	RIPLET	RIPLET	NNP
cord-350836-1enteev7	475	31	in	in	IN
cord-350836-1enteev7	475	32	innate	innate	JJ
cord-350836-1enteev7	475	33	immunity	immunity	NN
cord-350836-1enteev7	475	34	TRIM25	TRIM25	NNP
cord-350836-1enteev7	475	35	RINGfinger	ringfinger	NN
cord-350836-1enteev7	475	36	E3	e3	NN
cord-350836-1enteev7	475	37	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	475	38	ligase	ligase	NN
cord-350836-1enteev7	475	39	is	be	VBZ
cord-350836-1enteev7	475	40	essential	essential	JJ
cord-350836-1enteev7	475	41	for	for	IN
cord-350836-1enteev7	475	42	RIG	rig	NN
cord-350836-1enteev7	475	43	-	-	HYPH
cord-350836-1enteev7	475	44	I	i	NN
cord-350836-1enteev7	475	45	-	-	HYPH
cord-350836-1enteev7	475	46	mediated	mediate	VBN
cord-350836-1enteev7	475	47	antiviral	antiviral	JJ
cord-350836-1enteev7	475	48	activity	activity	NN
cord-350836-1enteev7	475	49	Caspase-12	Caspase-12	''
cord-350836-1enteev7	475	50	controls	control	VBZ
cord-350836-1enteev7	475	51	West	West	NNP
cord-350836-1enteev7	475	52	Nile	Nile	NNP
cord-350836-1enteev7	475	53	virus	virus	NN
cord-350836-1enteev7	475	54	infection	infection	NN
cord-350836-1enteev7	475	55	via	via	IN
cord-350836-1enteev7	475	56	the	the	DT
cord-350836-1enteev7	475	57	viral	viral	JJ
cord-350836-1enteev7	475	58	RNA	RNA	NNP
cord-350836-1enteev7	475	59	receptor	receptor	NN
cord-350836-1enteev7	475	60	RIG	rig	NN
cord-350836-1enteev7	475	61	-	-	:
cord-350836-1enteev7	475	62	I	i	NN
cord-350836-1enteev7	476	1	The	the	DT
cord-350836-1enteev7	476	2	long	long	JJ
cord-350836-1enteev7	476	3	noncoding	noncoding	JJ
cord-350836-1enteev7	476	4	RNA	RNA	NNP
cord-350836-1enteev7	476	5	Lnczc3h7a	Lnczc3h7a	NNP
cord-350836-1enteev7	476	6	promotes	promote	VBZ
cord-350836-1enteev7	476	7	a	a	DT
cord-350836-1enteev7	476	8	TRIM25-mediated	trim25-mediated	JJ
cord-350836-1enteev7	476	9	RIG	rig	NN
cord-350836-1enteev7	476	10	-	-	:
cord-350836-1enteev7	476	11	I	-PRON-	PRP
cord-350836-1enteev7	476	12	antiviral	antiviral	JJ
cord-350836-1enteev7	476	13	innate	innate	VBP
cord-350836-1enteev7	476	14	immune	immune	JJ
cord-350836-1enteev7	476	15	response	response	NN
cord-350836-1enteev7	477	1	Ube2D3	ube2d3	JJ
cord-350836-1enteev7	478	1	and	and	CC
cord-350836-1enteev7	478	2	Ube2N	Ube2N	NNS
cord-350836-1enteev7	478	3	are	be	VBP
cord-350836-1enteev7	478	4	essential	essential	JJ
cord-350836-1enteev7	478	5	for	for	IN
cord-350836-1enteev7	478	6	RIG	rig	NN
cord-350836-1enteev7	478	7	-	-	HYPH
cord-350836-1enteev7	478	8	I	i	NN
cord-350836-1enteev7	478	9	-	-	HYPH
cord-350836-1enteev7	478	10	mediated	mediate	VBN
cord-350836-1enteev7	478	11	MAVS	MAVS	NNP
cord-350836-1enteev7	478	12	aggregation	aggregation	NN
cord-350836-1enteev7	478	13	in	in	IN
cord-350836-1enteev7	478	14	antiviral	antiviral	JJ
cord-350836-1enteev7	478	15	innate	innate	JJ
cord-350836-1enteev7	478	16	immunity	immunity	NN
cord-350836-1enteev7	479	1	NDR2	NDR2	NNP
cord-350836-1enteev7	479	2	promotes	promote	VBZ
cord-350836-1enteev7	479	3	the	the	DT
cord-350836-1enteev7	479	4	antiviral	antiviral	JJ
cord-350836-1enteev7	479	5	immune	immune	JJ
cord-350836-1enteev7	479	6	response	response	NN
cord-350836-1enteev7	479	7	via	via	IN
cord-350836-1enteev7	479	8	facilitating	facilitate	VBG
cord-350836-1enteev7	479	9	TRIM25-mediated	trim25-mediate	VBN
cord-350836-1enteev7	479	10	RIG	rig	NN
cord-350836-1enteev7	480	1	-I	-i	DT
cord-350836-1enteev7	480	2	activation	activation	NN
cord-350836-1enteev7	480	3	in	in	IN
cord-350836-1enteev7	480	4	macrophages	macrophage	NNS
cord-350836-1enteev7	481	1	The	the	DT
cord-350836-1enteev7	481	2	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	481	3	-	-	HYPH
cord-350836-1enteev7	481	4	specific	specific	JJ
cord-350836-1enteev7	481	5	protease	protease	NN
cord-350836-1enteev7	481	6	USP15	USP15	NNP
cord-350836-1enteev7	481	7	promotes	promote	VBZ
cord-350836-1enteev7	481	8	RIG	rig	NN
cord-350836-1enteev7	481	9	-	-	HYPH
cord-350836-1enteev7	481	10	Imediated	imediate	VBN
cord-350836-1enteev7	481	11	antiviral	antiviral	JJ
cord-350836-1enteev7	481	12	signaling	signal	VBG
cord-350836-1enteev7	481	13	by	by	IN
cord-350836-1enteev7	481	14	deubiquitylating	deubiquitylate	VBG
cord-350836-1enteev7	481	15	TRIM25	TRIM25	NNP
cord-350836-1enteev7	482	1	The	the	DT
cord-350836-1enteev7	482	2	mitochondrial	mitochondrial	NN
cord-350836-1enteev7	482	3	targeting	target	VBG
cord-350836-1enteev7	482	4	chaperone	chaperone	NN
cord-350836-1enteev7	482	5	14	14	CD
cord-350836-1enteev7	482	6	-	-	SYM
cord-350836-1enteev7	482	7	3	3	CD
cord-350836-1enteev7	482	8	-	-	HYPH
cord-350836-1enteev7	482	9	3ε	3ε	NNP
cord-350836-1enteev7	482	10	regulates	regulate	VBZ
cord-350836-1enteev7	482	11	a	a	DT
cord-350836-1enteev7	482	12	RIG	rig	NN
cord-350836-1enteev7	482	13	-	-	:
cord-350836-1enteev7	482	14	I	-PRON-	PRP
cord-350836-1enteev7	482	15	translocon	translocon	NN
cord-350836-1enteev7	482	16	that	that	WDT
cord-350836-1enteev7	482	17	mediates	mediate	VBZ
cord-350836-1enteev7	482	18	membrane	membrane	NNP
cord-350836-1enteev7	482	19	association	association	NN
cord-350836-1enteev7	482	20	and	and	CC
cord-350836-1enteev7	483	1	innate	innate	JJ
cord-350836-1enteev7	483	2	antiviral	antiviral	JJ
cord-350836-1enteev7	483	3	immunity	immunity	NN
cord-350836-1enteev7	483	4	TRIM4	TRIM4	NNP
cord-350836-1enteev7	483	5	modulates	modulate	VBZ
cord-350836-1enteev7	483	6	type	type	NN
cord-350836-1enteev7	484	1	I	-PRON-	PRP
cord-350836-1enteev7	484	2	interferon	interferon	VBD
cord-350836-1enteev7	484	3	induction	induction	NN
cord-350836-1enteev7	484	4	and	and	CC
cord-350836-1enteev7	484	5	cellular	cellular	JJ
cord-350836-1enteev7	484	6	antiviral	antiviral	JJ
cord-350836-1enteev7	484	7	response	response	NN
cord-350836-1enteev7	484	8	by	by	IN
cord-350836-1enteev7	484	9	targeting	target	VBG
cord-350836-1enteev7	484	10	RIG	rig	NN
cord-350836-1enteev7	484	11	-	-	:
cord-350836-1enteev7	484	12	I	I	NNP
cord-350836-1enteev7	484	13	for	for	IN
cord-350836-1enteev7	484	14	K63-linked	K63-linked	NNP
cord-350836-1enteev7	484	15	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	484	16	Mechanism	Mechanism	NNP
cord-350836-1enteev7	484	17	of	of	IN
cord-350836-1enteev7	484	18	TRIM25	TRIM25	NNP
cord-350836-1enteev7	484	19	catalytic	catalytic	JJ
cord-350836-1enteev7	484	20	activation	activation	NN
cord-350836-1enteev7	484	21	in	in	IN
cord-350836-1enteev7	484	22	the	the	DT
cord-350836-1enteev7	484	23	antiviral	antiviral	JJ
cord-350836-1enteev7	484	24	RIG	rig	NN
cord-350836-1enteev7	485	1	-I	-i	WDT
cord-350836-1enteev7	485	2	pathway	pathway	NN
cord-350836-1enteev7	485	3	Influenza	Influenza	NNP
cord-350836-1enteev7	485	4	A	A	NNP
cord-350836-1enteev7	485	5	virus	virus	NN
cord-350836-1enteev7	485	6	NS1	ns1	CD
cord-350836-1enteev7	485	7	targets	target	VBZ
cord-350836-1enteev7	485	8	the	the	DT
cord-350836-1enteev7	485	9	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	485	10	ligase	ligase	NN
cord-350836-1enteev7	485	11	TRIM25	TRIM25	NNP
cord-350836-1enteev7	485	12	to	to	TO
cord-350836-1enteev7	485	13	evade	evade	VB
cord-350836-1enteev7	485	14	recognition	recognition	NN
cord-350836-1enteev7	485	15	by	by	IN
cord-350836-1enteev7	485	16	the	the	DT
cord-350836-1enteev7	485	17	host	host	NN
cord-350836-1enteev7	485	18	viral	viral	JJ
cord-350836-1enteev7	485	19	RNA	RNA	NNP
cord-350836-1enteev7	485	20	sensor	sensor	NN
cord-350836-1enteev7	485	21	RIG	rig	NN
cord-350836-1enteev7	485	22	-	-	:
cord-350836-1enteev7	485	23	I	I	NNP
cord-350836-1enteev7	485	24	Species	species	NN
cord-350836-1enteev7	485	25	-	-	HYPH
cord-350836-1enteev7	485	26	specific	specific	JJ
cord-350836-1enteev7	485	27	inhibition	inhibition	NN
cord-350836-1enteev7	485	28	of	of	IN
cord-350836-1enteev7	485	29	RIG	rig	NN
cord-350836-1enteev7	485	30	-	-	:
cord-350836-1enteev7	485	31	I	-PRON-	PRP
cord-350836-1enteev7	485	32	ubiquitination	ubiquitination	RB
cord-350836-1enteev7	485	33	and	and	CC
cord-350836-1enteev7	485	34	IFN	IFN	NNP
cord-350836-1enteev7	485	35	induction	induction	NN
cord-350836-1enteev7	485	36	by	by	IN
cord-350836-1enteev7	485	37	the	the	DT
cord-350836-1enteev7	485	38	influenza	influenza	NN
cord-350836-1enteev7	485	39	A	a	DT
cord-350836-1enteev7	485	40	virus	virus	NN
cord-350836-1enteev7	485	41	NS1	ns1	UH
cord-350836-1enteev7	485	42	protein	protein	NN
cord-350836-1enteev7	485	43	The	the	DT
cord-350836-1enteev7	485	44	human	human	JJ
cord-350836-1enteev7	485	45	papillomavirus	papillomavirus	NN
cord-350836-1enteev7	485	46	E6	E6	NNP
cord-350836-1enteev7	485	47	oncoprotein	oncoprotein	NNP
cord-350836-1enteev7	485	48	targets	target	NNS
cord-350836-1enteev7	485	49	USP15	USP15	NNP
cord-350836-1enteev7	485	50	and	and	CC
cord-350836-1enteev7	485	51	TRIM25	TRIM25	NNP
cord-350836-1enteev7	485	52	to	to	TO
cord-350836-1enteev7	485	53	suppress	suppress	VB
cord-350836-1enteev7	485	54	RIG	rig	NN
cord-350836-1enteev7	485	55	-	-	HYPH
cord-350836-1enteev7	485	56	I	i	NN
cord-350836-1enteev7	485	57	-	-	HYPH
cord-350836-1enteev7	485	58	mediated	mediate	VBN
cord-350836-1enteev7	485	59	innate	innate	JJ
cord-350836-1enteev7	485	60	immune	immune	NN
cord-350836-1enteev7	485	61	signaling	signal	VBG
cord-350836-1enteev7	485	62	Molecular	molecular	JJ
cord-350836-1enteev7	485	63	mechanism	mechanism	NN
cord-350836-1enteev7	485	64	of	of	IN
cord-350836-1enteev7	485	65	influenza	influenza	NN
cord-350836-1enteev7	485	66	A	a	DT
cord-350836-1enteev7	485	67	NS1-mediated	ns1-mediate	VBN
cord-350836-1enteev7	485	68	TRIM25	TRIM25	NNP
cord-350836-1enteev7	485	69	recognition	recognition	NN
cord-350836-1enteev7	485	70	and	and	CC
cord-350836-1enteev7	485	71	inhibition	inhibition	NN
cord-350836-1enteev7	485	72	NLRP12	NLRP12	NNP
cord-350836-1enteev7	485	73	regulates	regulate	VBZ
cord-350836-1enteev7	485	74	anti	anti	JJ
cord-350836-1enteev7	485	75	-	-	JJ
cord-350836-1enteev7	485	76	viral	viral	JJ
cord-350836-1enteev7	485	77	RIG-	rig-	NN
cord-350836-1enteev7	486	1	I	-PRON-	PRP
cord-350836-1enteev7	486	2	activation	activation	VBP
cord-350836-1enteev7	486	3	via	via	IN
cord-350836-1enteev7	486	4	interaction	interaction	NN
cord-350836-1enteev7	486	5	with	with	IN
cord-350836-1enteev7	486	6	TRIM25	TRIM25	NNP
cord-350836-1enteev7	486	7	Reconstitution	Reconstitution	NNP
cord-350836-1enteev7	486	8	of	of	IN
cord-350836-1enteev7	486	9	the	the	DT
cord-350836-1enteev7	486	10	RIG-	RIG-	NNP
cord-350836-1enteev7	487	1	I	-PRON-	PRP
cord-350836-1enteev7	487	2	pathway	pathway	VBP
cord-350836-1enteev7	487	3	reveals	reveal	VBZ
cord-350836-1enteev7	487	4	a	a	DT
cord-350836-1enteev7	487	5	signaling	signal	VBG
cord-350836-1enteev7	487	6	role	role	NN
cord-350836-1enteev7	487	7	of	of	IN
cord-350836-1enteev7	487	8	unanchored	unanchored	JJ
cord-350836-1enteev7	487	9	polyubiquitin	polyubiquitin	NNS
cord-350836-1enteev7	487	10	chains	chain	NNS
cord-350836-1enteev7	487	11	in	in	IN
cord-350836-1enteev7	487	12	innate	innate	JJ
cord-350836-1enteev7	487	13	immunity	immunity	NN
cord-350836-1enteev7	487	14	Emerging	emerge	VBG
cord-350836-1enteev7	487	15	role	role	NN
cord-350836-1enteev7	487	16	of	of	IN
cord-350836-1enteev7	487	17	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	487	18	in	in	IN
cord-350836-1enteev7	487	19	antiviral	antiviral	JJ
cord-350836-1enteev7	487	20	RIG	rig	NN
cord-350836-1enteev7	487	21	-	-	:
cord-350836-1enteev7	487	22	I	-PRON-	PRP
cord-350836-1enteev7	487	23	signaling	signal	VBG
cord-350836-1enteev7	487	24	A	a	DT
cord-350836-1enteev7	487	25	hierarchical	hierarchical	JJ
cord-350836-1enteev7	487	26	mechanism	mechanism	NN
cord-350836-1enteev7	487	27	of	of	IN
cord-350836-1enteev7	487	28	RIG	rig	NN
cord-350836-1enteev7	487	29	-	-	:
cord-350836-1enteev7	487	30	I	-PRON-	PRP
cord-350836-1enteev7	487	31	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	487	32	provides	provide	VBZ
cord-350836-1enteev7	487	33	sensitivity	sensitivity	NN
cord-350836-1enteev7	487	34	,	,	,
cord-350836-1enteev7	487	35	robustness	robustness	NN
cord-350836-1enteev7	487	36	and	and	CC
cord-350836-1enteev7	487	37	synergy	synergy	NN
cord-350836-1enteev7	487	38	in	in	IN
cord-350836-1enteev7	487	39	antiviral	antiviral	JJ
cord-350836-1enteev7	487	40	immune	immune	JJ
cord-350836-1enteev7	487	41	responses	response	NNS
cord-350836-1enteev7	487	42	Stratified	stratify	VBN
cord-350836-1enteev7	487	43	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	487	44	of	of	IN
cord-350836-1enteev7	487	45	RIG	rig	NN
cord-350836-1enteev7	487	46	-	-	:
cord-350836-1enteev7	487	47	I	-PRON-	PRP
cord-350836-1enteev7	487	48	creates	create	VBZ
cord-350836-1enteev7	487	49	robust	robust	JJ
cord-350836-1enteev7	487	50	immune	immune	JJ
cord-350836-1enteev7	487	51	response	response	NN
cord-350836-1enteev7	487	52	and	and	CC
cord-350836-1enteev7	487	53	induces	induce	VBZ
cord-350836-1enteev7	487	54	selective	selective	JJ
cord-350836-1enteev7	487	55	gene	gene	NN
cord-350836-1enteev7	487	56	expression	expression	NN
cord-350836-1enteev7	487	57	Ubiquitin	Ubiquitin	NNP
cord-350836-1enteev7	487	58	-	-	HYPH
cord-350836-1enteev7	487	59	mediated	mediate	VBN
cord-350836-1enteev7	487	60	modulation	modulation	NN
cord-350836-1enteev7	487	61	of	of	IN
cord-350836-1enteev7	487	62	the	the	DT
cord-350836-1enteev7	487	63	cytoplasmic	cytoplasmic	JJ
cord-350836-1enteev7	487	64	viral	viral	JJ
cord-350836-1enteev7	487	65	RNA	RNA	NNP
cord-350836-1enteev7	487	66	sensor	sensor	NN
cord-350836-1enteev7	487	67	RIG	rig	NN
cord-350836-1enteev7	487	68	-	-	:
cord-350836-1enteev7	487	69	I	i	NN
cord-350836-1enteev7	488	1	The	the	DT
cord-350836-1enteev7	488	2	E3	e3	NN
cord-350836-1enteev7	488	3	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	488	4	ligase	ligase	NN
cord-350836-1enteev7	488	5	TRIM40	trim40	NN
cord-350836-1enteev7	488	6	attenuates	attenuate	VBZ
cord-350836-1enteev7	488	7	antiviral	antiviral	JJ
cord-350836-1enteev7	488	8	immune	immune	JJ
cord-350836-1enteev7	488	9	responses	response	NNS
cord-350836-1enteev7	488	10	by	by	IN
cord-350836-1enteev7	488	11	targeting	target	VBG
cord-350836-1enteev7	488	12	MDA5	MDA5	NNP
cord-350836-1enteev7	488	13	and	and	CC
cord-350836-1enteev7	488	14	RIG	rig	NN
cord-350836-1enteev7	488	15	-	-	HYPH
cord-350836-1enteev7	488	16	I.	i.	NN
cord-350836-1enteev7	488	17	Cell	Cell	NNP
cord-350836-1enteev7	488	18	Rep	Rep	NNP
cord-350836-1enteev7	488	19	Regulation	Regulation	NNP
cord-350836-1enteev7	488	20	of	of	IN
cord-350836-1enteev7	488	21	RIG-	RIG-	NNP
cord-350836-1enteev7	489	1	I	-PRON-	PRP
cord-350836-1enteev7	489	2	activation	activation	VBP
cord-350836-1enteev7	489	3	by	by	IN
cord-350836-1enteev7	489	4	K63-linked	K63-linked	NNP
cord-350836-1enteev7	489	5	polyubiquitination	polyubiquitination	NN
cord-350836-1enteev7	489	6	.	.	.
cord-350836-1enteev7	490	1	Front	Front	NNP
cord-350836-1enteev7	490	2	Immunol	Immunol	NNP
cord-350836-1enteev7	491	1	The	the	DT
cord-350836-1enteev7	491	2	zincfinger	zincfinger	NNP
cord-350836-1enteev7	491	3	protein	protein	NN
cord-350836-1enteev7	491	4	ZCCHC3	ZCCHC3	NNP
cord-350836-1enteev7	491	5	binds	bind	VBZ
cord-350836-1enteev7	491	6	RNA	RNA	NNP
cord-350836-1enteev7	491	7	and	and	CC
cord-350836-1enteev7	491	8	facilitates	facilitate	VBZ
cord-350836-1enteev7	491	9	viral	viral	JJ
cord-350836-1enteev7	491	10	RNA	RNA	NNP
cord-350836-1enteev7	491	11	sensing	sensing	NN
cord-350836-1enteev7	491	12	and	and	CC
cord-350836-1enteev7	491	13	activation	activation	NN
cord-350836-1enteev7	491	14	of	of	IN
cord-350836-1enteev7	491	15	the	the	DT
cord-350836-1enteev7	491	16	RIG	rig	NN
cord-350836-1enteev7	491	17	-	-	HYPH
cord-350836-1enteev7	491	18	I	i	NN
cord-350836-1enteev7	491	19	-	-	HYPH
cord-350836-1enteev7	491	20	like	like	JJ
cord-350836-1enteev7	491	21	receptors	receptor	NNS
cord-350836-1enteev7	491	22	West	West	NNP
cord-350836-1enteev7	491	23	Nile	Nile	NNP
cord-350836-1enteev7	491	24	virus	virus	NN
cord-350836-1enteev7	491	25	NS1	ns1	NN
cord-350836-1enteev7	491	26	antagonizes	antagonize	VBZ
cord-350836-1enteev7	491	27	interferon	interferon	NN
cord-350836-1enteev7	491	28	beta	beta	NN
cord-350836-1enteev7	491	29	production	production	NN
cord-350836-1enteev7	491	30	by	by	IN
cord-350836-1enteev7	491	31	targeting	target	VBG
cord-350836-1enteev7	491	32	RIG	rig	NN
cord-350836-1enteev7	491	33	-	-	:
cord-350836-1enteev7	491	34	I	I	NNP
cord-350836-1enteev7	491	35	and	and	CC
cord-350836-1enteev7	491	36	MDA5	MDA5	NNP
cord-350836-1enteev7	492	1	TRIM65-catalized	TRIM65-catalized	NNP
cord-350836-1enteev7	492	2	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	492	3	is	be	VBZ
cord-350836-1enteev7	492	4	essential	essential	JJ
cord-350836-1enteev7	492	5	for	for	IN
cord-350836-1enteev7	492	6	MDA5-mediated	MDA5-mediated	NNP
cord-350836-1enteev7	492	7	antiviral	antiviral	JJ
cord-350836-1enteev7	492	8	innate	innate	JJ
cord-350836-1enteev7	492	9	immunity	immunity	NN
cord-350836-1enteev7	492	10	Structural	structural	JJ
cord-350836-1enteev7	492	11	basis	basis	NN
cord-350836-1enteev7	492	12	for	for	IN
cord-350836-1enteev7	492	13	ubiquitinmediated	ubiquitinmediated	JJ
cord-350836-1enteev7	492	14	antiviral	antiviral	JJ
cord-350836-1enteev7	492	15	signal	signal	NN
cord-350836-1enteev7	492	16	activation	activation	NN
cord-350836-1enteev7	492	17	by	by	IN
cord-350836-1enteev7	492	18	RIG	rig	NN
cord-350836-1enteev7	492	19	-	-	:
cord-350836-1enteev7	492	20	I	-PRON-	PRP
cord-350836-1enteev7	492	21	MAVS	MAVS	NNP
cord-350836-1enteev7	492	22	self	self	NN
cord-350836-1enteev7	492	23	-	-	HYPH
cord-350836-1enteev7	492	24	association	association	NN
cord-350836-1enteev7	492	25	mediates	mediate	VBZ
cord-350836-1enteev7	492	26	antiviral	antiviral	JJ
cord-350836-1enteev7	492	27	innate	innate	JJ
cord-350836-1enteev7	492	28	immune	immune	NN
cord-350836-1enteev7	492	29	signaling	signal	VBG
cord-350836-1enteev7	492	30	MAVS	MAVS	NNP
cord-350836-1enteev7	492	31	forms	form	VBZ
cord-350836-1enteev7	492	32	functional	functional	JJ
cord-350836-1enteev7	492	33	prion	prion	NN
cord-350836-1enteev7	492	34	-	-	HYPH
cord-350836-1enteev7	492	35	like	like	JJ
cord-350836-1enteev7	492	36	aggregates	aggregate	NNS
cord-350836-1enteev7	492	37	to	to	TO
cord-350836-1enteev7	492	38	activate	activate	VB
cord-350836-1enteev7	492	39	and	and	CC
cord-350836-1enteev7	492	40	propagate	propagate	VB
cord-350836-1enteev7	492	41	antiviral	antiviral	JJ
cord-350836-1enteev7	492	42	innate	innate	JJ
cord-350836-1enteev7	492	43	immune	immune	JJ
cord-350836-1enteev7	492	44	response	response	NN
cord-350836-1enteev7	493	1	Structural	structural	JJ
cord-350836-1enteev7	493	2	basis	basis	NN
cord-350836-1enteev7	493	3	for	for	IN
cord-350836-1enteev7	493	4	the	the	DT
cord-350836-1enteev7	493	5	prion	prion	NN
cord-350836-1enteev7	493	6	-	-	HYPH
cord-350836-1enteev7	493	7	like	like	IN
cord-350836-1enteev7	493	8	MAVS	MAVS	NNP
cord-350836-1enteev7	493	9	filaments	filament	NNS
cord-350836-1enteev7	493	10	in	in	IN
cord-350836-1enteev7	493	11	antiviral	antiviral	JJ
cord-350836-1enteev7	493	12	innate	innate	JJ
cord-350836-1enteev7	493	13	immunity	immunity	NN
cord-350836-1enteev7	493	14	Solid	solid	JJ
cord-350836-1enteev7	493	15	-	-	HYPH
cord-350836-1enteev7	493	16	state	state	NN
cord-350836-1enteev7	493	17	NMR	nmr	NN
cord-350836-1enteev7	493	18	resonance	resonance	NN
cord-350836-1enteev7	493	19	assignments	assignment	NNS
cord-350836-1enteev7	493	20	of	of	IN
cord-350836-1enteev7	493	21	the	the	DT
cord-350836-1enteev7	493	22	filament	filament	NN
cord-350836-1enteev7	493	23	-	-	HYPH
cord-350836-1enteev7	493	24	forming	form	VBG
cord-350836-1enteev7	493	25	CARD	card	NN
cord-350836-1enteev7	493	26	domain	domain	NN
cord-350836-1enteev7	493	27	of	of	IN
cord-350836-1enteev7	493	28	the	the	DT
cord-350836-1enteev7	493	29	innate	innate	JJ
cord-350836-1enteev7	493	30	immunity	immunity	NN
cord-350836-1enteev7	493	31	signaling	signal	VBG
cord-350836-1enteev7	493	32	protein	protein	NN
cord-350836-1enteev7	493	33	MAVS	mavs	RB
cord-350836-1enteev7	494	1	How	how	WRB
cord-350836-1enteev7	494	2	RIG	rig	NN
cord-350836-1enteev7	494	3	-	-	:
cord-350836-1enteev7	494	4	I	-PRON-	PRP
cord-350836-1enteev7	494	5	like	like	VBP
cord-350836-1enteev7	494	6	receptors	receptor	NNS
cord-350836-1enteev7	494	7	activate	activate	VBP
cord-350836-1enteev7	494	8	MAVS	MAVS	NNP
cord-350836-1enteev7	494	9	Visualizing	visualize	VBG
cord-350836-1enteev7	494	10	the	the	DT
cord-350836-1enteev7	494	11	determinants	determinant	NNS
cord-350836-1enteev7	494	12	of	of	IN
cord-350836-1enteev7	494	13	viral	viral	JJ
cord-350836-1enteev7	494	14	RNA	RNA	NNP
cord-350836-1enteev7	494	15	recognition	recognition	NN
cord-350836-1enteev7	494	16	by	by	IN
cord-350836-1enteev7	494	17	innate	innate	JJ
cord-350836-1enteev7	494	18	immune	immune	JJ
cord-350836-1enteev7	494	19	sensor	sensor	NN
cord-350836-1enteev7	494	20	RIG	rig	NN
cord-350836-1enteev7	495	1	-I	-i	WDT
cord-350836-1enteev7	495	2	Defining	define	VBG
cord-350836-1enteev7	495	3	the	the	DT
cord-350836-1enteev7	495	4	functional	functional	JJ
cord-350836-1enteev7	495	5	determinants	determinant	NNS
cord-350836-1enteev7	495	6	for	for	IN
cord-350836-1enteev7	495	7	RNA	rna	NN
cord-350836-1enteev7	495	8	surveillance	surveillance	NN
cord-350836-1enteev7	495	9	by	by	IN
cord-350836-1enteev7	495	10	RIG	rig	NN
cord-350836-1enteev7	495	11	-	-	:
cord-350836-1enteev7	495	12	I	i	NN
cord-350836-1enteev7	496	1	A	a	DT
cord-350836-1enteev7	496	2	minimal	minimal	JJ
cord-350836-1enteev7	496	3	RNA	rna	NN
cord-350836-1enteev7	496	4	ligand	ligand	NN
cord-350836-1enteev7	496	5	for	for	IN
cord-350836-1enteev7	496	6	potent	potent	JJ
cord-350836-1enteev7	496	7	RIG	rig	NN
cord-350836-1enteev7	497	1	-I	-i	DT
cord-350836-1enteev7	497	2	activation	activation	NN
cord-350836-1enteev7	497	3	in	in	IN
cord-350836-1enteev7	497	4	living	live	VBG
cord-350836-1enteev7	497	5	mice	mouse	NNS
cord-350836-1enteev7	498	1	ATPasedriven	ATPasedriven	NNP
cord-350836-1enteev7	498	2	oligomerization	oligomerization	NN
cord-350836-1enteev7	498	3	of	of	IN
cord-350836-1enteev7	498	4	RIG	rig	NN
cord-350836-1enteev7	498	5	-	-	:
cord-350836-1enteev7	498	6	I	-PRON-	PRP
cord-350836-1enteev7	498	7	on	on	IN
cord-350836-1enteev7	498	8	RNA	RNA	NNP
cord-350836-1enteev7	498	9	allows	allow	VBZ
cord-350836-1enteev7	498	10	optimal	optimal	JJ
cord-350836-1enteev7	498	11	activation	activation	NN
cord-350836-1enteev7	498	12	of	of	IN
cord-350836-1enteev7	498	13	type	type	NN
cord-350836-1enteev7	498	14	-	-	:
cord-350836-1enteev7	498	15	I	-PRON-	PRP
cord-350836-1enteev7	498	16	interferon	interferon	NN
cord-350836-1enteev7	498	17	RIG	rig	NN
cord-350836-1enteev7	499	1	-I	-I	JJS
cord-350836-1enteev7	499	2	forms	form	NNS
cord-350836-1enteev7	499	3	signaling	signal	VBG
cord-350836-1enteev7	499	4	-	-	HYPH
cord-350836-1enteev7	499	5	competent	competent	JJ
cord-350836-1enteev7	499	6	filaments	filament	NNS
cord-350836-1enteev7	499	7	in	in	IN
cord-350836-1enteev7	499	8	an	an	DT
cord-350836-1enteev7	499	9	ATP	ATP	NNP
cord-350836-1enteev7	499	10	-	-	HYPH
cord-350836-1enteev7	499	11	dependent	dependent	JJ
cord-350836-1enteev7	499	12	,	,	,
cord-350836-1enteev7	499	13	ubiquitin	ubiquitin	JJ
cord-350836-1enteev7	499	14	-	-	HYPH
cord-350836-1enteev7	499	15	independent	independent	JJ
cord-350836-1enteev7	499	16	manner	manner	NN
cord-350836-1enteev7	500	1	Molecular	molecular	JJ
cord-350836-1enteev7	500	2	mechanism	mechanism	NN
cord-350836-1enteev7	500	3	of	of	IN
cord-350836-1enteev7	500	4	signal	signal	JJ
cord-350836-1enteev7	500	5	perception	perception	NN
cord-350836-1enteev7	500	6	and	and	CC
cord-350836-1enteev7	500	7	integration	integration	NN
cord-350836-1enteev7	500	8	by	by	IN
cord-350836-1enteev7	500	9	the	the	DT
cord-350836-1enteev7	500	10	innate	innate	JJ
cord-350836-1enteev7	500	11	immune	immune	JJ
cord-350836-1enteev7	500	12	sensor	sensor	NN
cord-350836-1enteev7	500	13	retinoic	retinoic	JJ
cord-350836-1enteev7	500	14	acid	acid	NN
cord-350836-1enteev7	500	15	-	-	HYPH
cord-350836-1enteev7	500	16	inducible	inducible	JJ
cord-350836-1enteev7	500	17	gene	gene	NN
cord-350836-1enteev7	500	18	-	-	:
cord-350836-1enteev7	500	19	I	i	NN
cord-350836-1enteev7	500	20	(	(	-LRB-
cord-350836-1enteev7	500	21	RIG	rig	NN
cord-350836-1enteev7	500	22	-	-	:
cord-350836-1enteev7	500	23	I	i	NN
cord-350836-1enteev7	500	24	)	)	-RRB-
cord-350836-1enteev7	500	25	RIG	rig	NN
cord-350836-1enteev7	501	1	-I	-I	NNP
cord-350836-1enteev7	501	2	uses	use	VBZ
cord-350836-1enteev7	501	3	an	an	DT
cord-350836-1enteev7	501	4	ATPase	ATPase	NNP
cord-350836-1enteev7	501	5	-	-	HYPH
cord-350836-1enteev7	501	6	powered	power	VBN
cord-350836-1enteev7	501	7	translocation	translocation	NN
cord-350836-1enteev7	501	8	-	-	HYPH
cord-350836-1enteev7	501	9	throttling	throttle	VBG
cord-350836-1enteev7	501	10	mechanism	mechanism	NN
cord-350836-1enteev7	501	11	for	for	IN
cord-350836-1enteev7	501	12	kinetic	kinetic	JJ
cord-350836-1enteev7	501	13	proofreading	proofreading	NN
cord-350836-1enteev7	501	14	of	of	IN
cord-350836-1enteev7	501	15	RNAs	rna	NNS
cord-350836-1enteev7	501	16	and	and	CC
cord-350836-1enteev7	501	17	oligomerization	oligomerization	NN
cord-350836-1enteev7	501	18	Filament	Filament	NNP
cord-350836-1enteev7	501	19	assemblies	assembly	NNS
cord-350836-1enteev7	501	20	in	in	IN
cord-350836-1enteev7	501	21	foreign	foreign	JJ
cord-350836-1enteev7	501	22	nucleic	nucleic	JJ
cord-350836-1enteev7	501	23	acid	acid	NN
cord-350836-1enteev7	501	24	sensors	sensor	NNS
cord-350836-1enteev7	501	25	IPS-1	IPS-1	NNP
cord-350836-1enteev7	501	26	,	,	,
cord-350836-1enteev7	501	27	an	an	DT
cord-350836-1enteev7	501	28	adaptor	adaptor	NN
cord-350836-1enteev7	501	29	triggering	trigger	VBG
cord-350836-1enteev7	501	30	RIG	rig	NN
cord-350836-1enteev7	501	31	-	-	HYPH
cord-350836-1enteev7	501	32	I	i	NN
cord-350836-1enteev7	501	33	-	-	HYPH
cord-350836-1enteev7	501	34	and	and	CC
cord-350836-1enteev7	501	35	Mda5-mediated	Mda5-mediated	NNP
cord-350836-1enteev7	501	36	type	type	NN
cord-350836-1enteev7	502	1	I	-PRON-	PRP
cord-350836-1enteev7	503	1	interferon	interferon	NNP
cord-350836-1enteev7	503	2	induction	induction	NN
cord-350836-1enteev7	503	3	VISA	VISA	NNP
cord-350836-1enteev7	503	4	is	be	VBZ
cord-350836-1enteev7	503	5	an	an	DT
cord-350836-1enteev7	503	6	adapter	adapter	NN
cord-350836-1enteev7	503	7	protein	protein	NN
cord-350836-1enteev7	503	8	required	require	VBN
cord-350836-1enteev7	503	9	for	for	IN
cord-350836-1enteev7	503	10	virus	virus	NN
cord-350836-1enteev7	503	11	-	-	HYPH
cord-350836-1enteev7	503	12	triggered	trigger	VBN
cord-350836-1enteev7	503	13	IFN	IFN	NNP
cord-350836-1enteev7	503	14	-	-	HYPH
cord-350836-1enteev7	503	15	β	β	NNP
cord-350836-1enteev7	503	16	signaling	signal	VBG
cord-350836-1enteev7	503	17	Identification	identification	NN
cord-350836-1enteev7	503	18	and	and	CC
cord-350836-1enteev7	503	19	characterization	characterization	NN
cord-350836-1enteev7	503	20	of	of	IN
cord-350836-1enteev7	503	21	MAVS	MAVS	NNPS
cord-350836-1enteev7	503	22	,	,	,
cord-350836-1enteev7	503	23	a	a	DT
cord-350836-1enteev7	503	24	mitochondrial	mitochondrial	JJ
cord-350836-1enteev7	503	25	antiviral	antiviral	JJ
cord-350836-1enteev7	503	26	signaling	signal	VBG
cord-350836-1enteev7	503	27	protein	protein	NN
cord-350836-1enteev7	503	28	that	that	WDT
cord-350836-1enteev7	503	29	activates	activate	VBZ
cord-350836-1enteev7	503	30	NF	nf	NN
cord-350836-1enteev7	503	31	-	-	HYPH
cord-350836-1enteev7	503	32	κB	κB	NNP
cord-350836-1enteev7	503	33	and	and	CC
cord-350836-1enteev7	503	34	IRF3	IRF3	NNP
cord-350836-1enteev7	503	35	A	a	DT
cord-350836-1enteev7	503	36	common	common	JJ
cord-350836-1enteev7	503	37	polymorphism	polymorphism	NN
cord-350836-1enteev7	503	38	in	in	IN
cord-350836-1enteev7	503	39	the	the	DT
cord-350836-1enteev7	503	40	caspase	caspase	NN
cord-350836-1enteev7	503	41	recruitment	recruitment	NN
cord-350836-1enteev7	503	42	domain	domain	NN
cord-350836-1enteev7	503	43	of	of	IN
cord-350836-1enteev7	503	44	RIG	rig	NN
cord-350836-1enteev7	504	1	-I	-I	NNP
cord-350836-1enteev7	504	2	modifies	modify	VBZ
cord-350836-1enteev7	504	3	the	the	DT
cord-350836-1enteev7	504	4	innate	innate	JJ
cord-350836-1enteev7	504	5	immune	immune	JJ
cord-350836-1enteev7	504	6	response	response	NN
cord-350836-1enteev7	504	7	of	of	IN
cord-350836-1enteev7	504	8	human	human	JJ
cord-350836-1enteev7	504	9	dendritic	dendritic	JJ
cord-350836-1enteev7	504	10	cells	cell	NNS
cord-350836-1enteev7	504	11	Defective	defective	JJ
cord-350836-1enteev7	504	12	interfering	interfere	VBG
cord-350836-1enteev7	504	13	particles	particle	NNS
cord-350836-1enteev7	504	14	with	with	IN
cord-350836-1enteev7	504	15	covalently	covalently	RB
cord-350836-1enteev7	504	16	linked	link	VBN
cord-350836-1enteev7	504	17	[	[	-LRB-
cord-350836-1enteev7	504	18	+	+	CC
cord-350836-1enteev7	504	19	/-]RNA	/-]RNA	.
cord-350836-1enteev7	504	20	induce	induce	VB
cord-350836-1enteev7	504	21	interferon	interferon	NN
cord-350836-1enteev7	504	22	Structure	structure	NN
cord-350836-1enteev7	504	23	and	and	CC
cord-350836-1enteev7	504	24	dynamics	dynamic	NNS
cord-350836-1enteev7	504	25	of	of	IN
cord-350836-1enteev7	504	26	the	the	DT
cord-350836-1enteev7	504	27	second	second	JJ
cord-350836-1enteev7	504	28	CARD	card	NN
cord-350836-1enteev7	504	29	of	of	IN
cord-350836-1enteev7	504	30	human	human	JJ
cord-350836-1enteev7	504	31	RIG	rig	NN
cord-350836-1enteev7	505	1	-I	-i	WDT
cord-350836-1enteev7	505	2	provide	provide	VBP
cord-350836-1enteev7	505	3	mechanistic	mechanistic	JJ
cord-350836-1enteev7	505	4	insights	insight	NNS
cord-350836-1enteev7	505	5	into	into	IN
cord-350836-1enteev7	505	6	regulation	regulation	NN
cord-350836-1enteev7	505	7	of	of	IN
cord-350836-1enteev7	505	8	RIG-	RIG-	NNP
cord-350836-1enteev7	506	1	I	-PRON-	PRP
cord-350836-1enteev7	506	2	activation	activation	VBP
cord-350836-1enteev7	506	3	Pattern	Pattern	NNP
cord-350836-1enteev7	506	4	recognition	recognition	NN
cord-350836-1enteev7	506	5	receptors	receptor	NNS
cord-350836-1enteev7	506	6	and	and	CC
cord-350836-1enteev7	506	7	inflammation	inflammation	NN
cord-350836-1enteev7	506	8	Mitochondria	mitochondrion	NNS
cord-350836-1enteev7	506	9	in	in	IN
cord-350836-1enteev7	506	10	innate	innate	JJ
cord-350836-1enteev7	506	11	immunity	immunity	NN
cord-350836-1enteev7	506	12	Viral	viral	JJ
cord-350836-1enteev7	506	13	targeting	targeting	NN
cord-350836-1enteev7	506	14	of	of	IN
cord-350836-1enteev7	506	15	DEAD	DEAD	NNP
cord-350836-1enteev7	506	16	box	box	NN
cord-350836-1enteev7	506	17	protein	protein	NN
cord-350836-1enteev7	506	18	3	3	CD
cord-350836-1enteev7	506	19	reveals	reveal	VBZ
cord-350836-1enteev7	506	20	its	-PRON-	PRP$
cord-350836-1enteev7	506	21	role	role	NN
cord-350836-1enteev7	506	22	in	in	IN
cord-350836-1enteev7	506	23	TBK1	TBK1	NNP
cord-350836-1enteev7	506	24	/	/	SYM
cord-350836-1enteev7	506	25	IKKepsilon	IKKepsilon	NNP
cord-350836-1enteev7	506	26	-	-	HYPH
cord-350836-1enteev7	506	27	mediated	mediate	VBN
cord-350836-1enteev7	506	28	IRF	IRF	NNP
cord-350836-1enteev7	506	29	activation	activation	NN
cord-350836-1enteev7	506	30	Blockade	Blockade	NNP
cord-350836-1enteev7	506	31	of	of	IN
cord-350836-1enteev7	506	32	interferon	interferon	NN
cord-350836-1enteev7	506	33	beta	beta	NN
cord-350836-1enteev7	506	34	,	,	,
cord-350836-1enteev7	506	35	but	but	CC
cord-350836-1enteev7	506	36	not	not	RB
cord-350836-1enteev7	506	37	interferon	interferon	NN
cord-350836-1enteev7	506	38	alpha	alpha	NN
cord-350836-1enteev7	506	39	,	,	,
cord-350836-1enteev7	506	40	signaling	signal	VBG
cord-350836-1enteev7	506	41	controls	control	NNS
cord-350836-1enteev7	506	42	persistent	persistent	JJ
cord-350836-1enteev7	506	43	viral	viral	JJ
cord-350836-1enteev7	506	44	infection	infection	NN
cord-350836-1enteev7	507	1	The	the	DT
cord-350836-1enteev7	507	2	effects	effect	NNS
cord-350836-1enteev7	507	3	of	of	IN
cord-350836-1enteev7	507	4	dendritic	dendritic	JJ
cord-350836-1enteev7	507	5	cell	cell	NN
cord-350836-1enteev7	507	6	hypersensitivity	hypersensitivity	NN
cord-350836-1enteev7	507	7	on	on	IN
cord-350836-1enteev7	507	8	persistent	persistent	JJ
cord-350836-1enteev7	507	9	viral	viral	JJ
cord-350836-1enteev7	507	10	infection	infection	NN
cord-350836-1enteev7	507	11	A	a	DT
cord-350836-1enteev7	507	12	role	role	NN
cord-350836-1enteev7	507	13	for	for	IN
cord-350836-1enteev7	507	14	neutrophils	neutrophil	NNS
cord-350836-1enteev7	507	15	in	in	IN
cord-350836-1enteev7	507	16	viral	viral	JJ
cord-350836-1enteev7	507	17	respiratory	respiratory	JJ
cord-350836-1enteev7	507	18	disease	disease	NN
cord-350836-1enteev7	507	19	.	.	.
cord-350836-1enteev7	508	1	Front	Front	NNP
cord-350836-1enteev7	508	2	Immunol	Immunol	NNP
cord-350836-1enteev7	508	3	Plasmacytoid	Plasmacytoid	NNP
cord-350836-1enteev7	508	4	dendritic	dendritic	JJ
cord-350836-1enteev7	508	5	cells	cell	NNS
cord-350836-1enteev7	508	6	:	:	:
cord-350836-1enteev7	509	1	sensing	sensing	NN
cord-350836-1enteev7	509	2	nucleic	nucleic	JJ
cord-350836-1enteev7	509	3	acids	acid	NNS
cord-350836-1enteev7	509	4	in	in	IN
cord-350836-1enteev7	509	5	viral	viral	JJ
cord-350836-1enteev7	509	6	infection	infection	NN
cord-350836-1enteev7	509	7	and	and	CC
cord-350836-1enteev7	509	8	autoimmune	autoimmune	JJ
cord-350836-1enteev7	509	9	diseases	disease	NNS
cord-350836-1enteev7	510	1	An	an	DT
cord-350836-1enteev7	510	2	essential	essential	JJ
cord-350836-1enteev7	510	3	role	role	NN
cord-350836-1enteev7	510	4	for	for	IN
cord-350836-1enteev7	510	5	RIG	rig	NN
cord-350836-1enteev7	510	6	-	-	:
cord-350836-1enteev7	510	7	I	-PRON-	PRP
cord-350836-1enteev7	510	8	in	in	IN
cord-350836-1enteev7	510	9	toll	toll	NN
cord-350836-1enteev7	510	10	-	-	HYPH
cord-350836-1enteev7	510	11	like	like	JJ
cord-350836-1enteev7	510	12	receptor	receptor	NN
cord-350836-1enteev7	510	13	-	-	HYPH
cord-350836-1enteev7	510	14	stimulated	stimulate	VBN
cord-350836-1enteev7	510	15	phagocytosis	phagocytosis	NN
cord-350836-1enteev7	511	1	The	the	DT
cord-350836-1enteev7	511	2	long	long	JJ
cord-350836-1enteev7	511	3	noncoding	noncoding	JJ
cord-350836-1enteev7	511	4	RNA	RNA	NNP
cord-350836-1enteev7	511	5	NEAT1	NEAT1	NNP
cord-350836-1enteev7	511	6	exerts	exert	VBZ
cord-350836-1enteev7	511	7	antihantaviral	antihantaviral	JJ
cord-350836-1enteev7	511	8	effects	effect	NNS
cord-350836-1enteev7	511	9	by	by	IN
cord-350836-1enteev7	511	10	acting	act	VBG
cord-350836-1enteev7	511	11	as	as	IN
cord-350836-1enteev7	511	12	positive	positive	JJ
cord-350836-1enteev7	511	13	feedback	feedback	NN
cord-350836-1enteev7	511	14	for	for	IN
cord-350836-1enteev7	511	15	RIG	rig	NN
cord-350836-1enteev7	512	1	-I	-i	DT
cord-350836-1enteev7	512	2	signaling	signal	VBG
cord-350836-1enteev7	512	3	Differential	differential	JJ
cord-350836-1enteev7	512	4	viral	viral	JJ
cord-350836-1enteev7	512	5	induction	induction	NN
cord-350836-1enteev7	512	6	of	of	IN
cord-350836-1enteev7	512	7	distinct	distinct	JJ
cord-350836-1enteev7	512	8	interferonalpha	interferonalpha	JJ
cord-350836-1enteev7	512	9	genes	gene	NNS
cord-350836-1enteev7	512	10	by	by	IN
cord-350836-1enteev7	512	11	positive	positive	JJ
cord-350836-1enteev7	512	12	feedback	feedback	NN
cord-350836-1enteev7	512	13	through	through	IN
cord-350836-1enteev7	512	14	interferon	interferon	NN
cord-350836-1enteev7	512	15	regulatory	regulatory	JJ
cord-350836-1enteev7	512	16	factor-7	factor-7	NNS
cord-350836-1enteev7	513	1	The	the	DT
cord-350836-1enteev7	513	2	interferon	interferon	NN
cord-350836-1enteev7	513	3	response	response	NN
cord-350836-1enteev7	513	4	circuit	circuit	NN
cord-350836-1enteev7	513	5	:	:	:
cord-350836-1enteev7	514	1	Induction	induction	NN
cord-350836-1enteev7	514	2	and	and	CC
cord-350836-1enteev7	514	3	suppression	suppression	NN
cord-350836-1enteev7	514	4	by	by	IN
cord-350836-1enteev7	514	5	pathogenic	pathogenic	JJ
cord-350836-1enteev7	514	6	viruses	virus	NNS
cord-350836-1enteev7	514	7	H5N1	H5N1	NNP
cord-350836-1enteev7	514	8	influenza	influenza	NN
cord-350836-1enteev7	514	9	virus	virus	NN
cord-350836-1enteev7	514	10	-	-	HYPH
cord-350836-1enteev7	514	11	induced	induce	VBN
cord-350836-1enteev7	514	12	mediators	mediator	NNS
cord-350836-1enteev7	514	13	upregulate	upregulate	VBP
cord-350836-1enteev7	514	14	RIG-	rig-	NN
cord-350836-1enteev7	515	1	I	-PRON-	PRP
cord-350836-1enteev7	515	2	in	in	IN
cord-350836-1enteev7	515	3	uninfected	uninfected	JJ
cord-350836-1enteev7	515	4	cells	cell	NNS
cord-350836-1enteev7	515	5	by	by	IN
cord-350836-1enteev7	515	6	paracrine	paracrine	JJ
cord-350836-1enteev7	515	7	effects	effect	NNS
cord-350836-1enteev7	515	8	contributing	contribute	VBG
cord-350836-1enteev7	515	9	to	to	IN
cord-350836-1enteev7	515	10	amplified	amplified	JJ
cord-350836-1enteev7	515	11	cytokine	cytokine	NN
cord-350836-1enteev7	515	12	cascades	cascade	VBZ
cord-350836-1enteev7	515	13	Fundamental	fundamental	JJ
cord-350836-1enteev7	515	14	properties	property	NNS
cord-350836-1enteev7	515	15	of	of	IN
cord-350836-1enteev7	515	16	the	the	DT
cord-350836-1enteev7	515	17	mammalian	mammalian	JJ
cord-350836-1enteev7	515	18	innate	innate	JJ
cord-350836-1enteev7	515	19	immune	immune	JJ
cord-350836-1enteev7	515	20	system	system	NN
cord-350836-1enteev7	515	21	revealed	reveal	VBN
cord-350836-1enteev7	515	22	by	by	IN
cord-350836-1enteev7	515	23	multispecies	multispecie	NNS
cord-350836-1enteev7	515	24	comparison	comparison	NN
cord-350836-1enteev7	515	25	of	of	IN
cord-350836-1enteev7	515	26	type	type	NN
cord-350836-1enteev7	516	1	I	-PRON-	PRP
cord-350836-1enteev7	517	1	interferon	interferon	NNP
cord-350836-1enteev7	517	2	responses	response	NNS
cord-350836-1enteev7	518	1	Retinoic	Retinoic	NNP
cord-350836-1enteev7	518	2	acidinducible	acidinducible	JJ
cord-350836-1enteev7	518	3	gene	gene	NN
cord-350836-1enteev7	518	4	-	-	:
cord-350836-1enteev7	518	5	I	-PRON-	PRP
cord-350836-1enteev7	518	6	is	be	VBZ
cord-350836-1enteev7	518	7	induced	induce	VBN
cord-350836-1enteev7	518	8	by	by	IN
cord-350836-1enteev7	518	9	interferon	interferon	NN
cord-350836-1enteev7	518	10	-	-	HYPH
cord-350836-1enteev7	518	11	γ	γ	NN
cord-350836-1enteev7	518	12	and	and	CC
cord-350836-1enteev7	518	13	regulates	regulate	VBZ
cord-350836-1enteev7	518	14	the	the	DT
cord-350836-1enteev7	518	15	expression	expression	NN
cord-350836-1enteev7	518	16	of	of	IN
cord-350836-1enteev7	518	17	interferon	interferon	NN
cord-350836-1enteev7	518	18	-	-	HYPH
cord-350836-1enteev7	518	19	γ	γ	NN
cord-350836-1enteev7	518	20	stimulated	stimulate	VBD
cord-350836-1enteev7	518	21	gene	gene	NN
cord-350836-1enteev7	518	22	15	15	CD
cord-350836-1enteev7	518	23	in	in	IN
cord-350836-1enteev7	518	24	MCF-7	MCF-7	NNP
cord-350836-1enteev7	518	25	cells	cell	NNS
cord-350836-1enteev7	518	26	Expression	expression	NN
cord-350836-1enteev7	518	27	of	of	IN
cord-350836-1enteev7	518	28	retinoic	retinoic	JJ
cord-350836-1enteev7	518	29	acid	acid	NN
cord-350836-1enteev7	518	30	-	-	HYPH
cord-350836-1enteev7	518	31	inducible	inducible	JJ
cord-350836-1enteev7	518	32	gene	gene	NN
cord-350836-1enteev7	518	33	-	-	:
cord-350836-1enteev7	518	34	I	-PRON-	PRP
cord-350836-1enteev7	518	35	in	in	IN
cord-350836-1enteev7	518	36	vascular	vascular	JJ
cord-350836-1enteev7	518	37	smooth	smooth	JJ
cord-350836-1enteev7	518	38	muscle	muscle	NN
cord-350836-1enteev7	518	39	cells	cell	NNS
cord-350836-1enteev7	518	40	stimulated	stimulate	VBN
cord-350836-1enteev7	518	41	with	with	IN
cord-350836-1enteev7	518	42	interferon	interferon	NN
cord-350836-1enteev7	518	43	-	-	HYPH
cord-350836-1enteev7	518	44	γ	γ	NN
cord-350836-1enteev7	518	45	′	′	CD
cord-350836-1enteev7	519	1	-triphosphate	-triphosphate	NNP
cord-350836-1enteev7	519	2	RNA	RNA	NNP
cord-350836-1enteev7	519	3	requires	require	VBZ
cord-350836-1enteev7	519	4	base	base	NN
cord-350836-1enteev7	519	5	-	-	HYPH
cord-350836-1enteev7	519	6	paired	pair	VBN
cord-350836-1enteev7	519	7	structures	structure	NNS
cord-350836-1enteev7	519	8	to	to	TO
cord-350836-1enteev7	519	9	activate	activate	VB
cord-350836-1enteev7	519	10	antiviral	antiviral	JJ
cord-350836-1enteev7	519	11	signaling	signal	VBG
cord-350836-1enteev7	519	12	via	via	IN
cord-350836-1enteev7	519	13	RIG-	RIG-	NNP
cord-350836-1enteev7	520	1	I	-PRON-	PRP
cord-350836-1enteev7	520	2	Unpaired	Unpaired	NNP
cord-350836-1enteev7	520	3	5	5	CD
cord-350836-1enteev7	520	4	'	'	''
cord-350836-1enteev7	520	5	ppp	ppp	NN
cord-350836-1enteev7	520	6	-	-	HYPH
cord-350836-1enteev7	520	7	nucleotides	nucleotide	NNS
cord-350836-1enteev7	520	8	,	,	,
cord-350836-1enteev7	520	9	as	as	IN
cord-350836-1enteev7	520	10	found	find	VBN
cord-350836-1enteev7	520	11	in	in	IN
cord-350836-1enteev7	520	12	arenavirus	arenavirus	NNP
cord-350836-1enteev7	520	13	double	double	RB
cord-350836-1enteev7	520	14	-	-	HYPH
cord-350836-1enteev7	520	15	stranded	strand	VBN
cord-350836-1enteev7	520	16	RNA	rna	NN
cord-350836-1enteev7	520	17	panhandles	panhandle	NNS
cord-350836-1enteev7	520	18	,	,	,
cord-350836-1enteev7	520	19	are	be	VBP
cord-350836-1enteev7	520	20	not	not	RB
cord-350836-1enteev7	520	21	recognized	recognize	VBN
cord-350836-1enteev7	520	22	by	by	IN
cord-350836-1enteev7	520	23	RIG-	RIG-	NNP
cord-350836-1enteev7	521	1	I	-PRON-	PRP
cord-350836-1enteev7	521	2	Recognition	Recognition	NNP
cord-350836-1enteev7	521	3	of	of	IN
cord-350836-1enteev7	521	4	5	5	CD
cord-350836-1enteev7	521	5	'	'	''
cord-350836-1enteev7	521	6	triphosphate	triphosphate	NN
cord-350836-1enteev7	521	7	by	by	IN
cord-350836-1enteev7	521	8	RIG	rig	NN
cord-350836-1enteev7	522	1	-I	-i	DT
cord-350836-1enteev7	522	2	helicase	helicase	NNP
cord-350836-1enteev7	522	3	requires	require	VBZ
cord-350836-1enteev7	522	4	short	short	JJ
cord-350836-1enteev7	522	5	blunt	blunt	JJ
cord-350836-1enteev7	522	6	double	double	RB
cord-350836-1enteev7	522	7	-	-	HYPH
cord-350836-1enteev7	522	8	stranded	strand	VBN
cord-350836-1enteev7	522	9	RNA	RNA	NNP
cord-350836-1enteev7	522	10	as	as	IN
cord-350836-1enteev7	522	11	contained	contain	VBN
cord-350836-1enteev7	522	12	in	in	IN
cord-350836-1enteev7	522	13	panhandle	panhandle	NN
cord-350836-1enteev7	522	14	of	of	IN
cord-350836-1enteev7	522	15	negative	negative	JJ
cord-350836-1enteev7	522	16	-	-	HYPH
cord-350836-1enteev7	522	17	strand	strand	NN
cord-350836-1enteev7	522	18	virus	virus	NN
cord-350836-1enteev7	522	19	Short	short	JJ
cord-350836-1enteev7	522	20	double	double	RB
cord-350836-1enteev7	522	21	-	-	HYPH
cord-350836-1enteev7	522	22	stranded	stranded	JJ
cord-350836-1enteev7	522	23	RNAs	rna	NNS
cord-350836-1enteev7	522	24	with	with	IN
cord-350836-1enteev7	522	25	an	an	DT
cord-350836-1enteev7	522	26	overhanging	overhanging	JJ
cord-350836-1enteev7	522	27	5	5	CD
cord-350836-1enteev7	522	28	'	'	``
cord-350836-1enteev7	522	29	ppp	ppp	NN
cord-350836-1enteev7	522	30	-	-	HYPH
cord-350836-1enteev7	522	31	nucleotide	nucleotide	JJ
cord-350836-1enteev7	522	32	,	,	,
cord-350836-1enteev7	522	33	as	as	IN
cord-350836-1enteev7	522	34	found	find	VBN
cord-350836-1enteev7	522	35	in	in	IN
cord-350836-1enteev7	522	36	arenavirus	arenavirus	NNP
cord-350836-1enteev7	522	37	genomes	genome	NNS
cord-350836-1enteev7	522	38	,	,	,
cord-350836-1enteev7	522	39	act	act	VBP
cord-350836-1enteev7	522	40	as	as	IN
cord-350836-1enteev7	522	41	RIG	rig	NN
cord-350836-1enteev7	522	42	-	-	:
cord-350836-1enteev7	522	43	I	-PRON-	PRP
cord-350836-1enteev7	522	44	decoys	decoy	VBZ
cord-350836-1enteev7	522	45	Crystal	Crystal	NNP
cord-350836-1enteev7	522	46	structure	structure	NN
cord-350836-1enteev7	522	47	of	of	IN
cord-350836-1enteev7	522	48	RIG-	RIG-	NNP
cord-350836-1enteev7	523	1	I	-PRON-	PRP
cord-350836-1enteev7	523	2	C	C	NNP
cord-350836-1enteev7	523	3	-	-	HYPH
cord-350836-1enteev7	523	4	terminal	terminal	NN
cord-350836-1enteev7	523	5	domain	domain	NN
cord-350836-1enteev7	523	6	bound	bind	VBN
cord-350836-1enteev7	523	7	to	to	TO
cord-350836-1enteev7	523	8	blunt	blunt	VB
cord-350836-1enteev7	523	9	-	-	HYPH
cord-350836-1enteev7	523	10	ended	ended	JJ
cord-350836-1enteev7	523	11	double	double	JJ
cord-350836-1enteev7	523	12	-	-	HYPH
cord-350836-1enteev7	523	13	strand	strand	NN
cord-350836-1enteev7	523	14	RNA	RNA	NNP
cord-350836-1enteev7	523	15	without	without	IN
cord-350836-1enteev7	523	16	5	5	CD
cord-350836-1enteev7	523	17	'	'	''
cord-350836-1enteev7	523	18	triphosphate	triphosphate	NN
cord-350836-1enteev7	523	19	Antiviral	antiviral	JJ
cord-350836-1enteev7	523	20	immunity	immunity	NN
cord-350836-1enteev7	523	21	via	via	IN
cord-350836-1enteev7	523	22	RIG	rig	NN
cord-350836-1enteev7	523	23	-	-	HYPH
cord-350836-1enteev7	523	24	I	i	NN
cord-350836-1enteev7	523	25	-	-	HYPH
cord-350836-1enteev7	523	26	mediated	mediate	VBN
cord-350836-1enteev7	523	27	recognition	recognition	NN
cord-350836-1enteev7	523	28	of	of	IN
cord-350836-1enteev7	523	29	RNA	RNA	NNP
cord-350836-1enteev7	523	30	bearing	bearing	NN
cord-350836-1enteev7	523	31	5	5	CD
cord-350836-1enteev7	523	32	′	′	CD
cord-350836-1enteev7	523	33	-diphosphates	-diphosphates	NNPS
cord-350836-1enteev7	523	34	Energetics	energetic	NNS
cord-350836-1enteev7	523	35	of	of	IN
cord-350836-1enteev7	523	36	preferential	preferential	JJ
cord-350836-1enteev7	523	37	binding	binding	NN
cord-350836-1enteev7	523	38	of	of	IN
cord-350836-1enteev7	523	39	retinoic	retinoic	JJ
cord-350836-1enteev7	523	40	acid	acid	NN
cord-350836-1enteev7	523	41	-	-	HYPH
cord-350836-1enteev7	523	42	inducible	inducible	JJ
cord-350836-1enteev7	523	43	gene	gene	NN
cord-350836-1enteev7	523	44	-	-	:
cord-350836-1enteev7	523	45	I	i	NN
cord-350836-1enteev7	523	46	to	to	TO
cord-350836-1enteev7	523	47	double	double	RB
cord-350836-1enteev7	523	48	-	-	HYPH
cord-350836-1enteev7	523	49	stranded	strand	VBN
cord-350836-1enteev7	523	50	viral	viral	JJ
cord-350836-1enteev7	523	51	RNAs	rna	NNS
cord-350836-1enteev7	523	52	with	with	IN
cord-350836-1enteev7	523	53	5	5	CD
cord-350836-1enteev7	523	54	′	′	CD
cord-350836-1enteev7	523	55	Tri-/Diphosphate	tri-/diphosphate	VBP
cord-350836-1enteev7	523	56	over	over	IN
cord-350836-1enteev7	523	57	5	5	CD
cord-350836-1enteev7	523	58	′	′	CD
cord-350836-1enteev7	524	1	Monophosphate	Monophosphate	NNP
cord-350836-1enteev7	524	2	RIG	rig	NN
cord-350836-1enteev7	525	1	-I	-I	NFP
cord-350836-1enteev7	525	2	selectively	selectively	RB
cord-350836-1enteev7	525	3	discriminates	discriminate	VBZ
cord-350836-1enteev7	525	4	against	against	IN
cord-350836-1enteev7	525	5	5'-monophosphate	5'-monophosphate	NNP
cord-350836-1enteev7	525	6	RNA	RNA	NNP
cord-350836-1enteev7	525	7	Establishing	establish	VBG
cord-350836-1enteev7	525	8	the	the	DT
cord-350836-1enteev7	525	9	role	role	NN
cord-350836-1enteev7	525	10	of	of	IN
cord-350836-1enteev7	525	11	ATP	ATP	NNP
cord-350836-1enteev7	525	12	for	for	IN
cord-350836-1enteev7	525	13	the	the	DT
cord-350836-1enteev7	525	14	function	function	NN
cord-350836-1enteev7	525	15	of	of	IN
cord-350836-1enteev7	525	16	the	the	DT
cord-350836-1enteev7	525	17	RIG	rig	NN
cord-350836-1enteev7	525	18	-	-	:
cord-350836-1enteev7	525	19	I	-PRON-	PRP
cord-350836-1enteev7	525	20	innate	innate	VBP
cord-350836-1enteev7	525	21	immune	immune	JJ
cord-350836-1enteev7	525	22	sensor	sensor	NN
cord-350836-1enteev7	526	1	A	a	DT
cord-350836-1enteev7	527	1	mammalian	mammalian	JJ
cord-350836-1enteev7	527	2	pre	pre	NNP
cord-350836-1enteev7	527	3	-	-	NN
cord-350836-1enteev7	527	4	mRNA	mRNA	NNP
cord-350836-1enteev7	527	5	5	5	CD
cord-350836-1enteev7	527	6	'	'	NN
cord-350836-1enteev7	527	7	end	end	NN
cord-350836-1enteev7	527	8	capping	cap	VBG
cord-350836-1enteev7	527	9	quality	quality	NN
cord-350836-1enteev7	527	10	control	control	NN
cord-350836-1enteev7	527	11	mechanism	mechanism	NN
cord-350836-1enteev7	527	12	and	and	CC
cord-350836-1enteev7	527	13	an	an	DT
cord-350836-1enteev7	527	14	unexpected	unexpected	JJ
cord-350836-1enteev7	527	15	link	link	NN
cord-350836-1enteev7	527	16	of	of	IN
cord-350836-1enteev7	527	17	capping	cap	VBG
cord-350836-1enteev7	527	18	to	to	IN
cord-350836-1enteev7	527	19	pre	pre	VB
cord-350836-1enteev7	527	20	-	-	JJ
cord-350836-1enteev7	527	21	mRNA	mrna	JJ
cord-350836-1enteev7	527	22	processing	process	VBG
cord-350836-1enteev7	527	23	RNase	RNase	NNP
cord-350836-1enteev7	527	24	III	III	NNP
cord-350836-1enteev7	527	25	:	:	:
cord-350836-1enteev7	527	26	genetics	genetic	NNS
cord-350836-1enteev7	527	27	and	and	CC
cord-350836-1enteev7	527	28	function	function	NN
cord-350836-1enteev7	527	29	;	;	:
cord-350836-1enteev7	527	30	structure	structure	NN
cord-350836-1enteev7	527	31	and	and	CC
cord-350836-1enteev7	527	32	mechanism	mechanism	NN
cord-350836-1enteev7	528	1	RNase	RNase	NNP
cord-350836-1enteev7	528	2	L	L	NNP
cord-350836-1enteev7	528	3	releases	release	VBZ
cord-350836-1enteev7	528	4	a	a	DT
cord-350836-1enteev7	528	5	small	small	JJ
cord-350836-1enteev7	528	6	RNA	RNA	NNP
cord-350836-1enteev7	528	7	from	from	IN
cord-350836-1enteev7	528	8	HCV	HCV	NNP
cord-350836-1enteev7	528	9	RNA	RNA	NNP
cord-350836-1enteev7	528	10	that	that	IN
cord-350836-1enteev7	528	11	refolds	refold	VBZ
cord-350836-1enteev7	528	12	into	into	IN
cord-350836-1enteev7	528	13	a	a	DT
cord-350836-1enteev7	528	14	potent	potent	JJ
cord-350836-1enteev7	528	15	PAMP	PAMP	NNP
cord-350836-1enteev7	528	16	Activation	Activation	NNP
cord-350836-1enteev7	528	17	of	of	IN
cord-350836-1enteev7	528	18	innate	innate	JJ
cord-350836-1enteev7	528	19	immunity	immunity	NN
cord-350836-1enteev7	528	20	by	by	IN
cord-350836-1enteev7	528	21	mitochondrial	mitochondrial	JJ
cord-350836-1enteev7	528	22	dsRNA	dsrna	NN
cord-350836-1enteev7	528	23	in	in	IN
cord-350836-1enteev7	528	24	mouse	mouse	NN
cord-350836-1enteev7	528	25	cells	cell	NNS
cord-350836-1enteev7	528	26	lacking	lack	VBG
cord-350836-1enteev7	528	27	p53	p53	NN
cord-350836-1enteev7	528	28	protein	protein	NN
cord-350836-1enteev7	528	29	New	new	JJ
cord-350836-1enteev7	528	30	insights	insight	NNS
cord-350836-1enteev7	528	31	into	into	IN
cord-350836-1enteev7	528	32	the	the	DT
cord-350836-1enteev7	528	33	role	role	NN
cord-350836-1enteev7	528	34	of	of	IN
cord-350836-1enteev7	528	35	RNase	RNase	NNP
cord-350836-1enteev7	528	36	L	L	NNP
cord-350836-1enteev7	528	37	in	in	IN
cord-350836-1enteev7	528	38	innate	innate	JJ
cord-350836-1enteev7	528	39	immunity	immunity	NN
cord-350836-1enteev7	528	40	Structural	structural	JJ
cord-350836-1enteev7	528	41	basis	basis	NN
cord-350836-1enteev7	528	42	of	of	IN
cord-350836-1enteev7	528	43	double	double	RB
cord-350836-1enteev7	528	44	-	-	HYPH
cord-350836-1enteev7	528	45	stranded	strand	VBN
cord-350836-1enteev7	528	46	RNA	RNA	NNP
cord-350836-1enteev7	528	47	recognition	recognition	NN
cord-350836-1enteev7	528	48	by	by	IN
cord-350836-1enteev7	528	49	the	the	DT
cord-350836-1enteev7	528	50	RIG	rig	NN
cord-350836-1enteev7	528	51	-	-	:
cord-350836-1enteev7	528	52	I	-PRON-	PRP
cord-350836-1enteev7	528	53	like	like	VBP
cord-350836-1enteev7	528	54	receptor	receptor	NN
cord-350836-1enteev7	528	55	MDA5	MDA5	NNP
cord-350836-1enteev7	529	1	The	the	DT
cord-350836-1enteev7	529	2	RIG	rig	NN
cord-350836-1enteev7	529	3	-	-	HYPH
cord-350836-1enteev7	529	4	I	i	NN
cord-350836-1enteev7	529	5	-	-	HYPH
cord-350836-1enteev7	529	6	like	like	JJ
cord-350836-1enteev7	529	7	receptor	receptor	NN
cord-350836-1enteev7	529	8	LGP2	LGP2	NNP
cord-350836-1enteev7	529	9	recognizes	recognize	VBZ
cord-350836-1enteev7	529	10	the	the	DT
cord-350836-1enteev7	529	11	termini	terminus	NNS
cord-350836-1enteev7	529	12	of	of	IN
cord-350836-1enteev7	529	13	doublestranded	doublestranded	NNP
cord-350836-1enteev7	529	14	RNA	RNA	NNP
cord-350836-1enteev7	529	15	Evolution	Evolution	NNP
cord-350836-1enteev7	529	16	of	of	IN
cord-350836-1enteev7	529	17	MDA-5	MDA-5	NNP
cord-350836-1enteev7	529	18	/	/	SYM
cord-350836-1enteev7	529	19	RIG	rig	NN
cord-350836-1enteev7	529	20	-	-	HYPH
cord-350836-1enteev7	529	21	I	i	NN
cord-350836-1enteev7	529	22	-	-	HYPH
cord-350836-1enteev7	529	23	dependent	dependent	JJ
cord-350836-1enteev7	529	24	innate	innate	JJ
cord-350836-1enteev7	529	25	immunity	immunity	NN
cord-350836-1enteev7	529	26	:	:	:
cord-350836-1enteev7	529	27	independent	independent	JJ
cord-350836-1enteev7	529	28	evolution	evolution	NN
cord-350836-1enteev7	529	29	by	by	IN
cord-350836-1enteev7	529	30	domain	domain	NN
cord-350836-1enteev7	529	31	grafting	graft	VBG
cord-350836-1enteev7	529	32	Regulation	regulation	NN
cord-350836-1enteev7	529	33	of	of	IN
cord-350836-1enteev7	529	34	innate	innate	JJ
cord-350836-1enteev7	529	35	antiviral	antiviral	JJ
cord-350836-1enteev7	529	36	defenses	defense	NNS
cord-350836-1enteev7	529	37	through	through	IN
cord-350836-1enteev7	529	38	a	a	DT
cord-350836-1enteev7	529	39	shared	share	VBN
cord-350836-1enteev7	529	40	repressor	repressor	NN
cord-350836-1enteev7	529	41	domain	domain	NN
cord-350836-1enteev7	529	42	in	in	IN
cord-350836-1enteev7	529	43	RIG	rig	NN
cord-350836-1enteev7	529	44	-	-	:
cord-350836-1enteev7	529	45	I	I	NNP
cord-350836-1enteev7	529	46	and	and	CC
cord-350836-1enteev7	529	47	LGP2	LGP2	NNP
cord-350836-1enteev7	529	48	Activation	Activation	NNP
cord-350836-1enteev7	529	49	of	of	IN
cord-350836-1enteev7	529	50	IFN	IFN	NNP
cord-350836-1enteev7	529	51	-	-	HYPH
cord-350836-1enteev7	529	52	β	β	NNP
cord-350836-1enteev7	529	53	expression	expression	NN
cord-350836-1enteev7	529	54	by	by	IN
cord-350836-1enteev7	529	55	a	a	DT
cord-350836-1enteev7	529	56	viral	viral	JJ
cord-350836-1enteev7	529	57	mRNA	mrna	NN
cord-350836-1enteev7	529	58	through	through	IN
cord-350836-1enteev7	529	59	RNase	RNase	NNP
cord-350836-1enteev7	529	60	L	L	NNP
cord-350836-1enteev7	529	61	and	and	CC
cord-350836-1enteev7	529	62	MDA5	MDA5	NNP
cord-350836-1enteev7	529	63	RIG-	RIG-	NNP
cord-350836-1enteev7	530	1	I	-PRON-	PRP
cord-350836-1enteev7	530	2	and	and	CC
cord-350836-1enteev7	530	3	Other	Other	NNP
cord-350836-1enteev7	530	4	RNA	RNA	NNP
cord-350836-1enteev7	530	5	Sensors	Sensors	NNPS
cord-350836-1enteev7	530	6	in	in	IN
cord-350836-1enteev7	530	7	Antiviral	Antiviral	NNP
cord-350836-1enteev7	530	8	Immunity	Immunity	NNP
cord-350836-1enteev7	530	9	RNA	RNA	NNP
cord-350836-1enteev7	530	10	polymerase	polymerase	NN
cord-350836-1enteev7	530	11	III	III	NNP
cord-350836-1enteev7	530	12	detects	detect	VBZ
cord-350836-1enteev7	530	13	cytosolic	cytosolic	JJ
cord-350836-1enteev7	530	14	DNA	dna	NN
cord-350836-1enteev7	530	15	and	and	CC
cord-350836-1enteev7	530	16	induces	induce	VBZ
cord-350836-1enteev7	530	17	type	type	NN
cord-350836-1enteev7	530	18	I	-PRON-	PRP
cord-350836-1enteev7	530	19	interferons	interferon	NNS
cord-350836-1enteev7	530	20	through	through	IN
cord-350836-1enteev7	530	21	the	the	DT
cord-350836-1enteev7	530	22	RIG	rig	NN
cord-350836-1enteev7	530	23	-	-	:
cord-350836-1enteev7	530	24	I	-PRON-	PRP
cord-350836-1enteev7	530	25	pathway	pathway	NN
cord-350836-1enteev7	530	26	RIG	rig	NN
cord-350836-1enteev7	530	27	-	-	HYPH
cord-350836-1enteev7	530	28	I	i	NN
cord-350836-1enteev7	530	29	-	-	HYPH
cord-350836-1enteev7	530	30	dependent	dependent	JJ
cord-350836-1enteev7	530	31	sensing	sensing	NN
cord-350836-1enteev7	530	32	of	of	IN
cord-350836-1enteev7	530	33	poly(dA	poly(dA	NNP
cord-350836-1enteev7	530	34	:	:	:
cord-350836-1enteev7	530	35	dT	dT	NNP
cord-350836-1enteev7	530	36	)	)	-RRB-
cord-350836-1enteev7	530	37	through	through	IN
cord-350836-1enteev7	530	38	the	the	DT
cord-350836-1enteev7	530	39	induction	induction	NN
cord-350836-1enteev7	530	40	of	of	IN
cord-350836-1enteev7	530	41	an	an	DT
cord-350836-1enteev7	530	42	RNA	RNA	NNP
cord-350836-1enteev7	530	43	polymerase	polymerase	NN
cord-350836-1enteev7	530	44	III	III	NNP
cord-350836-1enteev7	530	45	-	-	HYPH
cord-350836-1enteev7	530	46	transcribed	transcribe	VBN
cord-350836-1enteev7	530	47	RNA	RNA	NNP
cord-350836-1enteev7	530	48	intermediate	intermediate	JJ
cord-350836-1enteev7	530	49	Sequence	sequence	NN
cord-350836-1enteev7	530	50	-	-	HYPH
cord-350836-1enteev7	530	51	specific	specific	JJ
cord-350836-1enteev7	530	52	modifications	modification	NNS
cord-350836-1enteev7	530	53	enhance	enhance	VBP
cord-350836-1enteev7	530	54	the	the	DT
cord-350836-1enteev7	530	55	broad	broad	JJ
cord-350836-1enteev7	530	56	-	-	HYPH
cord-350836-1enteev7	530	57	spectrum	spectrum	NN
cord-350836-1enteev7	530	58	antiviral	antiviral	JJ
cord-350836-1enteev7	530	59	response	response	NN
cord-350836-1enteev7	530	60	activated	activate	VBN
cord-350836-1enteev7	530	61	by	by	IN
cord-350836-1enteev7	530	62	RIG-	RIG-	NNP
cord-350836-1enteev7	531	1	I	-PRON-	PRP
cord-350836-1enteev7	531	2	agonists	agonist	NNS
cord-350836-1enteev7	532	1	RIG-	RIG-	NNP
cord-350836-1enteev7	533	1	I	-PRON-	PRP
cord-350836-1enteev7	533	2	activation	activation	VBP
cord-350836-1enteev7	533	3	by	by	IN
cord-350836-1enteev7	533	4	a	a	DT
cord-350836-1enteev7	533	5	designer	designer	NN
cord-350836-1enteev7	533	6	short	short	JJ
cord-350836-1enteev7	533	7	RNA	RNA	NNP
cord-350836-1enteev7	533	8	ligand	ligand	NN
cord-350836-1enteev7	533	9	protects	protect	VBZ
cord-350836-1enteev7	533	10	human	human	JJ
cord-350836-1enteev7	533	11	immune	immune	JJ
cord-350836-1enteev7	533	12	cells	cell	NNS
cord-350836-1enteev7	533	13	against	against	IN
cord-350836-1enteev7	533	14	dengue	dengue	NN
cord-350836-1enteev7	533	15	virus	virus	NN
cord-350836-1enteev7	533	16	infection	infection	NN
cord-350836-1enteev7	533	17	without	without	IN
cord-350836-1enteev7	533	18	causing	cause	VBG
cord-350836-1enteev7	533	19	cytotoxicity	cytotoxicity	NN
cord-350836-1enteev7	533	20	Identification	identification	NN
cord-350836-1enteev7	533	21	of	of	IN
cord-350836-1enteev7	533	22	a	a	DT
cord-350836-1enteev7	533	23	natural	natural	JJ
cord-350836-1enteev7	533	24	viral	viral	JJ
cord-350836-1enteev7	533	25	RNA	RNA	NNP
cord-350836-1enteev7	533	26	motif	motif	NN
cord-350836-1enteev7	533	27	that	that	WDT
cord-350836-1enteev7	533	28	optimizes	optimize	VBZ
cord-350836-1enteev7	533	29	sensing	sensing	NN
cord-350836-1enteev7	533	30	of	of	IN
cord-350836-1enteev7	533	31	viral	viral	JJ
cord-350836-1enteev7	533	32	RNA	RNA	NNP
cord-350836-1enteev7	533	33	by	by	IN
cord-350836-1enteev7	533	34	RIG	rig	NN
cord-350836-1enteev7	533	35	-	-	:
cord-350836-1enteev7	533	36	I	i	NN
cord-350836-1enteev7	534	1	In	in	IN
cord-350836-1enteev7	534	2	vivo	vivo	NN
cord-350836-1enteev7	534	3	ligands	ligand	NNS
cord-350836-1enteev7	534	4	of	of	IN
cord-350836-1enteev7	534	5	MDA5	MDA5	NNP
cord-350836-1enteev7	534	6	and	and	CC
cord-350836-1enteev7	534	7	RIG	rig	NN
cord-350836-1enteev7	534	8	-	-	:
cord-350836-1enteev7	534	9	I	-PRON-	PRP
cord-350836-1enteev7	534	10	in	in	IN
cord-350836-1enteev7	534	11	measles	measles	NN
cord-350836-1enteev7	534	12	virus	virus	NN
cord-350836-1enteev7	534	13	-	-	HYPH
cord-350836-1enteev7	534	14	infected	infect	VBN
cord-350836-1enteev7	534	15	cells	cell	NNS
cord-350836-1enteev7	535	1	The	the	DT
cord-350836-1enteev7	535	2	3	3	CD
cord-350836-1enteev7	535	3	'	'	POS
cord-350836-1enteev7	535	4	untranslated	untranslated	JJ
cord-350836-1enteev7	535	5	regions	region	NNS
cord-350836-1enteev7	535	6	of	of	IN
cord-350836-1enteev7	535	7	influenza	influenza	NN
cord-350836-1enteev7	535	8	genomic	genomic	JJ
cord-350836-1enteev7	535	9	sequences	sequence	NNS
cord-350836-1enteev7	535	10	are	be	VBP
cord-350836-1enteev7	535	11	5'PPP	5'ppp	CD
cord-350836-1enteev7	535	12	-	-	HYPH
cord-350836-1enteev7	535	13	independent	independent	JJ
cord-350836-1enteev7	535	14	ligands	ligand	NNS
cord-350836-1enteev7	535	15	for	for	IN
cord-350836-1enteev7	535	16	RIG-	RIG-	NNP
cord-350836-1enteev7	536	1	I	-PRON-	PRP
cord-350836-1enteev7	536	2	RIG	rig	VBP
cord-350836-1enteev7	537	1	-I	-I	NNP
cord-350836-1enteev7	537	2	detects	detect	VBZ
cord-350836-1enteev7	537	3	Kaposi	Kaposi	NNP
cord-350836-1enteev7	537	4	's	's	POS
cord-350836-1enteev7	537	5	sarcoma	sarcoma	NN
cord-350836-1enteev7	537	6	-	-	HYPH
cord-350836-1enteev7	537	7	associated	associate	VBN
cord-350836-1enteev7	537	8	herpesvirus	herpesvirus	NN
cord-350836-1enteev7	537	9	transcripts	transcript	NNS
cord-350836-1enteev7	537	10	in	in	IN
cord-350836-1enteev7	537	11	a	a	DT
cord-350836-1enteev7	537	12	RNA	RNA	NNP
cord-350836-1enteev7	537	13	polymerase	polymerase	NN
cord-350836-1enteev7	537	14	III	iii	CD
cord-350836-1enteev7	537	15	-	-	HYPH
cord-350836-1enteev7	537	16	independent	independent	JJ
cord-350836-1enteev7	537	17	manner	manner	NN
cord-350836-1enteev7	538	1	Innate	innate	JJ
cord-350836-1enteev7	538	2	immunity	immunity	NN
cord-350836-1enteev7	538	3	induced	induce	VBN
cord-350836-1enteev7	538	4	by	by	IN
cord-350836-1enteev7	538	5	composition	composition	NN
cord-350836-1enteev7	538	6	-	-	HYPH
cord-350836-1enteev7	538	7	dependent	dependent	JJ
cord-350836-1enteev7	538	8	RIG-	rig-	NN
cord-350836-1enteev7	539	1	I	-PRON-	PRP
cord-350836-1enteev7	539	2	recognition	recognition	NN
cord-350836-1enteev7	539	3	of	of	IN
cord-350836-1enteev7	539	4	hepatitis	hepatitis	NNP
cord-350836-1enteev7	539	5	C	C	NNP
cord-350836-1enteev7	539	6	virus	virus	NN
cord-350836-1enteev7	539	7	RNA	RNA	NNP
cord-350836-1enteev7	539	8	Nucleotide	Nucleotide	NNP
cord-350836-1enteev7	539	9	sequences	sequence	NNS
cord-350836-1enteev7	539	10	and	and	CC
cord-350836-1enteev7	539	11	modifications	modification	NNS
cord-350836-1enteev7	539	12	that	that	WDT
cord-350836-1enteev7	539	13	determine	determine	VBP
cord-350836-1enteev7	539	14	RIG	rig	NN
cord-350836-1enteev7	539	15	-	-	:
cord-350836-1enteev7	539	16	I	I	NNP
cord-350836-1enteev7	539	17	/	/	SYM
cord-350836-1enteev7	539	18	RNA	RNA	NNP
cord-350836-1enteev7	539	19	binding	binding	NN
cord-350836-1enteev7	539	20	and	and	CC
cord-350836-1enteev7	539	21	signaling	signal	VBG
cord-350836-1enteev7	540	1	activities	activity	NNS
cord-350836-1enteev7	540	2	Self	self	NN
cord-350836-1enteev7	540	3	-	-	HYPH
cord-350836-1enteev7	540	4	recognition	recognition	NN
cord-350836-1enteev7	540	5	of	of	IN
cord-350836-1enteev7	540	6	an	an	DT
cord-350836-1enteev7	540	7	inducible	inducible	JJ
cord-350836-1enteev7	540	8	host	host	NN
cord-350836-1enteev7	540	9	lncRNA	lncrna	NN
cord-350836-1enteev7	540	10	by	by	IN
cord-350836-1enteev7	540	11	RIG	rig	NN
cord-350836-1enteev7	541	1	-I	-i	DT
cord-350836-1enteev7	541	2	feedback	feedback	NN
cord-350836-1enteev7	541	3	restricts	restrict	VBZ
cord-350836-1enteev7	541	4	innate	innate	JJ
cord-350836-1enteev7	541	5	immune	immune	JJ
cord-350836-1enteev7	541	6	response	response	NN
cord-350836-1enteev7	541	7	Discrimination	discrimination	NN
cord-350836-1enteev7	541	8	of	of	IN
cord-350836-1enteev7	541	9	self	self	NN
cord-350836-1enteev7	541	10	and	and	CC
cord-350836-1enteev7	541	11	non	non	JJ
cord-350836-1enteev7	541	12	-	-	JJ
cord-350836-1enteev7	541	13	self	self	JJ
cord-350836-1enteev7	541	14	ribonucleic	ribonucleic	NN
cord-350836-1enteev7	541	15	acids	acid	NNS
cord-350836-1enteev7	541	16	Defective	defective	JJ
cord-350836-1enteev7	541	17	viral	viral	JJ
cord-350836-1enteev7	541	18	particles	particle	NNS
cord-350836-1enteev7	541	19	and	and	CC
cord-350836-1enteev7	542	1	viral	viral	JJ
cord-350836-1enteev7	542	2	disease	disease	NN
cord-350836-1enteev7	542	3	processes	process	VBZ
cord-350836-1enteev7	542	4	Defective	defective	JJ
cord-350836-1enteev7	542	5	interfering	interfere	VBG
cord-350836-1enteev7	542	6	viruses	virus	NNS
cord-350836-1enteev7	543	1	Further	further	JJ
cord-350836-1enteev7	543	2	characterization	characterization	NN
cord-350836-1enteev7	543	3	of	of	IN
cord-350836-1enteev7	543	4	Sendai	Sendai	NNP
cord-350836-1enteev7	543	5	virus	virus	NN
cord-350836-1enteev7	543	6	DI	DI	NNP
cord-350836-1enteev7	543	7	-	-	HYPH
cord-350836-1enteev7	543	8	RNAs	rna	NNS
cord-350836-1enteev7	543	9	:	:	:
cord-350836-1enteev7	544	1	a	a	DT
cord-350836-1enteev7	544	2	model	model	NN
cord-350836-1enteev7	544	3	for	for	IN
cord-350836-1enteev7	544	4	their	-PRON-	PRP$
cord-350836-1enteev7	544	5	generation	generation	NN
cord-350836-1enteev7	544	6	Structure	structure	NN
cord-350836-1enteev7	544	7	and	and	CC
cord-350836-1enteev7	544	8	origin	origin	NN
cord-350836-1enteev7	544	9	of	of	IN
cord-350836-1enteev7	544	10	a	a	DT
cord-350836-1enteev7	544	11	novel	novel	JJ
cord-350836-1enteev7	544	12	class	class	NN
cord-350836-1enteev7	544	13	of	of	IN
cord-350836-1enteev7	544	14	defective	defective	JJ
cord-350836-1enteev7	544	15	interfering	interfere	VBG
cord-350836-1enteev7	544	16	particle	particle	NN
cord-350836-1enteev7	544	17	of	of	IN
cord-350836-1enteev7	544	18	vesicular	vesicular	JJ
cord-350836-1enteev7	544	19	stomatitis	stomatitis	NN
cord-350836-1enteev7	544	20	virus	virus	NN
cord-350836-1enteev7	544	21	Activation	activation	NN
cord-350836-1enteev7	544	22	of	of	IN
cord-350836-1enteev7	544	23	the	the	DT
cord-350836-1enteev7	544	24	beta	beta	NN
cord-350836-1enteev7	544	25	interferon	interferon	NN
cord-350836-1enteev7	544	26	promoter	promoter	NN
cord-350836-1enteev7	544	27	by	by	IN
cord-350836-1enteev7	544	28	unnatural	unnatural	JJ
cord-350836-1enteev7	544	29	sendai	sendai	NNP
cord-350836-1enteev7	544	30	virus	virus	NN
cord-350836-1enteev7	544	31	infection	infection	NN
cord-350836-1enteev7	544	32	requires	require	VBZ
cord-350836-1enteev7	544	33	RIG	rig	NN
cord-350836-1enteev7	544	34	-	-	:
cord-350836-1enteev7	544	35	I	i	NN
cord-350836-1enteev7	544	36	and	and	CC
cord-350836-1enteev7	544	37	is	be	VBZ
cord-350836-1enteev7	544	38	inhibited	inhibit	VBN
cord-350836-1enteev7	544	39	by	by	IN
cord-350836-1enteev7	544	40	viral	viral	JJ
cord-350836-1enteev7	544	41	C	c	NN
cord-350836-1enteev7	544	42	proteins	protein	NNS
cord-350836-1enteev7	544	43	Preference	preference	NN
cord-350836-1enteev7	544	44	of	of	IN
cord-350836-1enteev7	544	45	RIG	rig	NN
cord-350836-1enteev7	544	46	-	-	:
cord-350836-1enteev7	544	47	I	-PRON-	PRP
cord-350836-1enteev7	544	48	for	for	IN
cord-350836-1enteev7	544	49	short	short	JJ
cord-350836-1enteev7	544	50	viral	viral	JJ
cord-350836-1enteev7	544	51	RNA	RNA	NNP
cord-350836-1enteev7	544	52	molecules	molecule	NNS
cord-350836-1enteev7	544	53	in	in	IN
cord-350836-1enteev7	544	54	infected	infected	JJ
cord-350836-1enteev7	544	55	cells	cell	NNS
cord-350836-1enteev7	544	56	revealed	reveal	VBN
cord-350836-1enteev7	544	57	by	by	IN
cord-350836-1enteev7	544	58	nextgeneration	nextgeneration	NN
cord-350836-1enteev7	544	59	sequencing	sequence	VBG
cord-350836-1enteev7	544	60	Differential	differential	JJ
cord-350836-1enteev7	544	61	recognition	recognition	NN
cord-350836-1enteev7	544	62	of	of	IN
cord-350836-1enteev7	544	63	viral	viral	JJ
cord-350836-1enteev7	544	64	RNA	RNA	NNP
cord-350836-1enteev7	544	65	by	by	IN
cord-350836-1enteev7	544	66	RIG	rig	NN
cord-350836-1enteev7	544	67	-	-	HYPH
cord-350836-1enteev7	544	68	I.	I.	NNP
cord-350836-1enteev7	544	69	Virulence	Virulence	NNP
cord-350836-1enteev7	544	70	PACT	PACT	NNP
cord-350836-1enteev7	544	71	-	-	:
cord-350836-1enteev7	544	72	and	and	CC
cord-350836-1enteev7	544	73	RIG	rig	NN
cord-350836-1enteev7	544	74	-	-	HYPH
cord-350836-1enteev7	544	75	I	i	NN
cord-350836-1enteev7	544	76	-	-	HYPH
cord-350836-1enteev7	544	77	dependent	dependent	JJ
cord-350836-1enteev7	544	78	activation	activation	NN
cord-350836-1enteev7	544	79	of	of	IN
cord-350836-1enteev7	544	80	type	type	NN
cord-350836-1enteev7	545	1	I	-PRON-	PRP
cord-350836-1enteev7	545	2	interferon	interferon	VBD
cord-350836-1enteev7	545	3	production	production	NN
cord-350836-1enteev7	545	4	by	by	IN
cord-350836-1enteev7	545	5	a	a	DT
cord-350836-1enteev7	545	6	defective	defective	JJ
cord-350836-1enteev7	545	7	interfering	interfere	VBG
cord-350836-1enteev7	545	8	RNA	RNA	NNP
cord-350836-1enteev7	545	9	derived	derive	VBN
cord-350836-1enteev7	545	10	from	from	IN
cord-350836-1enteev7	545	11	measles	measles	NNP
cord-350836-1enteev7	545	12	virus	virus	NN
cord-350836-1enteev7	545	13	vaccine	vaccine	NN
cord-350836-1enteev7	545	14	Inhibition	inhibition	NN
cord-350836-1enteev7	545	15	of	of	IN
cord-350836-1enteev7	545	16	ongoing	ongoing	JJ
cord-350836-1enteev7	545	17	influenza	influenza	NN
cord-350836-1enteev7	545	18	A	a	DT
cord-350836-1enteev7	545	19	virus	virus	NN
cord-350836-1enteev7	545	20	replication	replication	NN
cord-350836-1enteev7	545	21	reveals	reveal	VBZ
cord-350836-1enteev7	545	22	different	different	JJ
cord-350836-1enteev7	545	23	mechanisms	mechanism	NNS
cord-350836-1enteev7	545	24	of	of	IN
cord-350836-1enteev7	545	25	RIG	rig	NN
cord-350836-1enteev7	546	1	-I	-i	DT
cord-350836-1enteev7	546	2	activation	activation	NN
cord-350836-1enteev7	547	1	Influenza	Influenza	NNP
cord-350836-1enteev7	547	2	A	a	DT
cord-350836-1enteev7	547	3	virus	virus	NN
cord-350836-1enteev7	547	4	panhandle	panhandle	NN
cord-350836-1enteev7	547	5	structure	structure	NN
cord-350836-1enteev7	547	6	is	be	VBZ
cord-350836-1enteev7	547	7	directly	directly	RB
cord-350836-1enteev7	547	8	involved	involve	VBN
cord-350836-1enteev7	547	9	in	in	IN
cord-350836-1enteev7	547	10	RIG	rig	NN
cord-350836-1enteev7	547	11	-	-	:
cord-350836-1enteev7	547	12	I	-PRON-	PRP
cord-350836-1enteev7	547	13	activation	activation	NN
cord-350836-1enteev7	547	14	and	and	CC
cord-350836-1enteev7	547	15	interferon	interferon	NN
cord-350836-1enteev7	547	16	induction	induction	NN
cord-350836-1enteev7	548	1	The	the	DT
cord-350836-1enteev7	548	2	structure	structure	NN
cord-350836-1enteev7	548	3	of	of	IN
cord-350836-1enteev7	548	4	influenza	influenza	NN
cord-350836-1enteev7	548	5	virus	virus	NN
cord-350836-1enteev7	548	6	defective	defective	JJ
cord-350836-1enteev7	548	7	interfering	interfere	VBG
cord-350836-1enteev7	548	8	(	(	-LRB-
cord-350836-1enteev7	548	9	DI	DI	NNP
cord-350836-1enteev7	548	10	)	)	-RRB-
cord-350836-1enteev7	548	11	RNAs	rna	NNS
cord-350836-1enteev7	548	12	and	and	CC
cord-350836-1enteev7	548	13	their	-PRON-	PRP$
cord-350836-1enteev7	548	14	progenitor	progenitor	NN
cord-350836-1enteev7	548	15	genes	gene	NNS
cord-350836-1enteev7	548	16	MDA5	MDA5	NNP
cord-350836-1enteev7	548	17	participates	participate	VBZ
cord-350836-1enteev7	548	18	in	in	IN
cord-350836-1enteev7	548	19	the	the	DT
cord-350836-1enteev7	548	20	detection	detection	NN
cord-350836-1enteev7	548	21	of	of	IN
cord-350836-1enteev7	548	22	paramyxovirus	paramyxovirus	JJ
cord-350836-1enteev7	548	23	infection	infection	NN
cord-350836-1enteev7	548	24	and	and	CC
cord-350836-1enteev7	548	25	is	be	VBZ
cord-350836-1enteev7	548	26	essential	essential	JJ
cord-350836-1enteev7	548	27	for	for	IN
cord-350836-1enteev7	548	28	the	the	DT
cord-350836-1enteev7	548	29	early	early	JJ
cord-350836-1enteev7	548	30	activation	activation	NN
cord-350836-1enteev7	548	31	of	of	IN
cord-350836-1enteev7	548	32	dendritic	dendritic	JJ
cord-350836-1enteev7	548	33	cells	cell	NNS
cord-350836-1enteev7	548	34	in	in	IN
cord-350836-1enteev7	548	35	response	response	NN
cord-350836-1enteev7	548	36	to	to	IN
cord-350836-1enteev7	548	37	sendai	sendai	NNP
cord-350836-1enteev7	548	38	virus	virus	NN
cord-350836-1enteev7	548	39	defective	defective	JJ
cord-350836-1enteev7	548	40	interfering	interfere	VBG
cord-350836-1enteev7	548	41	particles	particle	NNS
cord-350836-1enteev7	549	1	A	a	DT
cord-350836-1enteev7	549	2	novel	novel	JJ
cord-350836-1enteev7	549	3	role	role	NN
cord-350836-1enteev7	549	4	for	for	IN
cord-350836-1enteev7	549	5	viral	viral	JJ
cord-350836-1enteev7	549	6	-	-	HYPH
cord-350836-1enteev7	549	7	defective	defective	JJ
cord-350836-1enteev7	549	8	interfering	interfere	VBG
cord-350836-1enteev7	549	9	particles	particle	NNS
cord-350836-1enteev7	549	10	in	in	IN
cord-350836-1enteev7	549	11	enhancing	enhance	VBG
cord-350836-1enteev7	549	12	dendritic	dendritic	JJ
cord-350836-1enteev7	549	13	cell	cell	NN
cord-350836-1enteev7	549	14	maturation	maturation	NN
cord-350836-1enteev7	549	15	Defective	defective	JJ
cord-350836-1enteev7	549	16	interfering	interfere	VBG
cord-350836-1enteev7	549	17	influenza	influenza	NN
cord-350836-1enteev7	549	18	virus	virus	NN
cord-350836-1enteev7	549	19	RNAs	rna	NNS
cord-350836-1enteev7	549	20	:	:	:
cord-350836-1enteev7	549	21	time	time	NN
cord-350836-1enteev7	549	22	to	to	TO
cord-350836-1enteev7	549	23	reevaluate	reevaluate	VB
cord-350836-1enteev7	549	24	their	-PRON-	PRP$
cord-350836-1enteev7	549	25	clinical	clinical	JJ
cord-350836-1enteev7	549	26	potential	potential	NN
cord-350836-1enteev7	549	27	as	as	IN
cord-350836-1enteev7	549	28	broad	broad	JJ
cord-350836-1enteev7	549	29	-	-	HYPH
cord-350836-1enteev7	549	30	spectrum	spectrum	NN
cord-350836-1enteev7	549	31	antivirals	antiviral	NNS
cord-350836-1enteev7	549	32	?	?	.
cord-350836-1enteev7	550	1	Biology	biology	NN
cord-350836-1enteev7	550	2	of	of	IN
cord-350836-1enteev7	550	3	immune	immune	JJ
cord-350836-1enteev7	550	4	responses	response	NNS
cord-350836-1enteev7	550	5	to	to	IN
cord-350836-1enteev7	550	6	vaccines	vaccine	NNS
cord-350836-1enteev7	550	7	in	in	IN
cord-350836-1enteev7	550	8	elderly	elderly	JJ
cord-350836-1enteev7	550	9	persons	person	NNS
cord-350836-1enteev7	550	10	Vaccination	vaccination	NN
cord-350836-1enteev7	550	11	in	in	IN
cord-350836-1enteev7	550	12	the	the	DT
cord-350836-1enteev7	550	13	elderly	elderly	JJ
cord-350836-1enteev7	550	14	:	:	:
cord-350836-1enteev7	550	15	an	an	DT
cord-350836-1enteev7	550	16	immunological	immunological	JJ
cord-350836-1enteev7	550	17	perspective	perspective	NN
cord-350836-1enteev7	550	18	Vaccination	vaccination	NN
cord-350836-1enteev7	550	19	in	in	IN
cord-350836-1enteev7	550	20	the	the	DT
cord-350836-1enteev7	550	21	elderly	elderly	JJ
cord-350836-1enteev7	550	22	Vaccination	vaccination	NN
cord-350836-1enteev7	550	23	in	in	IN
cord-350836-1enteev7	550	24	the	the	DT
cord-350836-1enteev7	550	25	elderly	elderly	JJ
cord-350836-1enteev7	550	26	:	:	:
cord-350836-1enteev7	550	27	the	the	DT
cord-350836-1enteev7	550	28	challenge	challenge	NN
cord-350836-1enteev7	550	29	of	of	IN
cord-350836-1enteev7	550	30	immune	immune	JJ
cord-350836-1enteev7	550	31	changes	change	NNS
cord-350836-1enteev7	550	32	with	with	IN
cord-350836-1enteev7	550	33	aging	age	VBG
cord-350836-1enteev7	550	34	Aging	age	VBG
cord-350836-1enteev7	550	35	impairs	impair	NNS
cord-350836-1enteev7	550	36	both	both	CC
cord-350836-1enteev7	550	37	primary	primary	JJ
cord-350836-1enteev7	550	38	and	and	CC
cord-350836-1enteev7	550	39	secondary	secondary	JJ
cord-350836-1enteev7	550	40	RIG	rig	NN
cord-350836-1enteev7	550	41	-	-	:
cord-350836-1enteev7	550	42	I	-PRON-	PRP
cord-350836-1enteev7	550	43	signaling	signal	VBG
cord-350836-1enteev7	550	44	for	for	IN
cord-350836-1enteev7	550	45	interferon	interferon	NN
cord-350836-1enteev7	550	46	induction	induction	NN
cord-350836-1enteev7	550	47	in	in	IN
cord-350836-1enteev7	550	48	human	human	JJ
cord-350836-1enteev7	550	49	monocytes	monocyte	NNS
cord-350836-1enteev7	551	1	Within	within	IN
cord-350836-1enteev7	551	2	-	-	HYPH
cord-350836-1enteev7	551	3	season	season	NN
cord-350836-1enteev7	551	4	influenza	influenza	NN
cord-350836-1enteev7	551	5	vaccine	vaccine	NN
cord-350836-1enteev7	551	6	waning	waning	NN
cord-350836-1enteev7	551	7	suggests	suggest	VBZ
cord-350836-1enteev7	551	8	potential	potential	JJ
cord-350836-1enteev7	551	9	net	net	JJ
cord-350836-1enteev7	551	10	benefits	benefit	NNS
cord-350836-1enteev7	551	11	to	to	IN
cord-350836-1enteev7	551	12	delayed	delay	VBN
cord-350836-1enteev7	551	13	vaccination	vaccination	NN
cord-350836-1enteev7	551	14	in	in	IN
cord-350836-1enteev7	551	15	older	old	JJR
cord-350836-1enteev7	551	16	adults	adult	NNS
cord-350836-1enteev7	551	17	in	in	IN
cord-350836-1enteev7	551	18	the	the	DT
cord-350836-1enteev7	551	19	United	United	NNP
cord-350836-1enteev7	551	20	States	States	NNP
cord-350836-1enteev7	551	21	Viral	Viral	NNP
cord-350836-1enteev7	551	22	persistence	persistence	NN
cord-350836-1enteev7	551	23	:	:	:
cord-350836-1enteev7	551	24	mechanisms	mechanism	NNS
cord-350836-1enteev7	551	25	and	and	CC
cord-350836-1enteev7	551	26	consequences	consequence	NNS
cord-350836-1enteev7	551	27	Defective	defective	JJ
cord-350836-1enteev7	551	28	(	(	-LRB-
cord-350836-1enteev7	551	29	interfering	interfere	VBG
cord-350836-1enteev7	551	30	)	)	-RRB-
cord-350836-1enteev7	551	31	viral	viral	JJ
cord-350836-1enteev7	551	32	genomes	genome	NNS
cord-350836-1enteev7	551	33	re	re	VBN
cord-350836-1enteev7	551	34	-	-	VBN
cord-350836-1enteev7	551	35	explored	explore	VBN
cord-350836-1enteev7	551	36	:	:	:
cord-350836-1enteev7	551	37	impact	impact	NN
cord-350836-1enteev7	551	38	on	on	IN
cord-350836-1enteev7	551	39	antiviral	antiviral	JJ
cord-350836-1enteev7	551	40	immunity	immunity	NN
cord-350836-1enteev7	551	41	and	and	CC
cord-350836-1enteev7	551	42	virus	virus	NN
cord-350836-1enteev7	551	43	persistence	persistence	NN
cord-350836-1enteev7	551	44	Multiple	multiple	JJ
cord-350836-1enteev7	551	45	-	-	HYPH
cord-350836-1enteev7	551	46	hit	hit	VBN
cord-350836-1enteev7	551	47	inhibition	inhibition	NN
cord-350836-1enteev7	551	48	of	of	IN
cord-350836-1enteev7	551	49	infection	infection	NN
cord-350836-1enteev7	551	50	by	by	IN
cord-350836-1enteev7	551	51	defective	defective	JJ
cord-350836-1enteev7	551	52	interfering	interfere	VBG
cord-350836-1enteev7	551	53	particles	particle	NNS
cord-350836-1enteev7	551	54	A	a	DT
cord-350836-1enteev7	551	55	novel	novel	JJ
cord-350836-1enteev7	551	56	phosphoserine	phosphoserine	JJ
cord-350836-1enteev7	551	57	motif	motif	NN
cord-350836-1enteev7	551	58	in	in	IN
cord-350836-1enteev7	551	59	the	the	DT
cord-350836-1enteev7	551	60	LCMV	LCMV	NNP
cord-350836-1enteev7	551	61	matrix	matrix	NN
cord-350836-1enteev7	551	62	protein	protein	NN
cord-350836-1enteev7	551	63	Z	Z	NNP
cord-350836-1enteev7	551	64	regulates	regulate	VBZ
cord-350836-1enteev7	551	65	the	the	DT
cord-350836-1enteev7	551	66	release	release	NN
cord-350836-1enteev7	551	67	of	of	IN
cord-350836-1enteev7	551	68	infectious	infectious	JJ
cord-350836-1enteev7	551	69	virus	virus	NN
cord-350836-1enteev7	551	70	and	and	CC
cord-350836-1enteev7	551	71	defective	defective	JJ
cord-350836-1enteev7	551	72	interfering	interfere	VBG
cord-350836-1enteev7	551	73	particles	particle	NNS
cord-350836-1enteev7	551	74	Hostdriven	Hostdriven	NNP
cord-350836-1enteev7	551	75	phosphorylation	phosphorylation	NN
cord-350836-1enteev7	551	76	appears	appear	VBZ
cord-350836-1enteev7	551	77	to	to	TO
cord-350836-1enteev7	551	78	regulate	regulate	VB
cord-350836-1enteev7	551	79	the	the	DT
cord-350836-1enteev7	551	80	budding	bud	VBG
cord-350836-1enteev7	551	81	activity	activity	NN
cord-350836-1enteev7	551	82	of	of	IN
cord-350836-1enteev7	551	83	the	the	DT
cord-350836-1enteev7	551	84	lassa	lassa	NNP
cord-350836-1enteev7	551	85	virus	virus	NN
cord-350836-1enteev7	551	86	matrix	matrix	NNP
cord-350836-1enteev7	551	87	protein	protein	NN
cord-350836-1enteev7	551	88	RIGorous	RIGorous	NNP
cord-350836-1enteev7	551	89	detection	detection	NN
cord-350836-1enteev7	551	90	:	:	:
cord-350836-1enteev7	551	91	exposing	expose	VBG
cord-350836-1enteev7	551	92	virus	virus	NN
cord-350836-1enteev7	551	93	through	through	IN
cord-350836-1enteev7	551	94	RNA	RNA	NNP
cord-350836-1enteev7	551	95	sensing	sensing	NN
cord-350836-1enteev7	551	96	Gain	gain	NN
cord-350836-1enteev7	551	97	-	-	HYPH
cord-350836-1enteev7	551	98	of	of	IN
cord-350836-1enteev7	551	99	-	-	HYPH
cord-350836-1enteev7	551	100	function	function	NN
cord-350836-1enteev7	551	101	mutations	mutation	NNS
cord-350836-1enteev7	551	102	in	in	IN
cord-350836-1enteev7	551	103	IFIH1	ifih1	PRP
cord-350836-1enteev7	551	104	cause	cause	VBP
cord-350836-1enteev7	551	105	a	a	DT
cord-350836-1enteev7	551	106	spectrum	spectrum	NN
cord-350836-1enteev7	551	107	of	of	IN
cord-350836-1enteev7	551	108	human	human	JJ
cord-350836-1enteev7	551	109	disease	disease	NN
cord-350836-1enteev7	551	110	phenotypes	phenotype	NNS
cord-350836-1enteev7	551	111	associated	associate	VBN
cord-350836-1enteev7	551	112	with	with	IN
cord-350836-1enteev7	551	113	upregulated	upregulated	JJ
cord-350836-1enteev7	551	114	type	type	NN
cord-350836-1enteev7	551	115	I	-PRON-	PRP
cord-350836-1enteev7	551	116	interferon	interferon	VBD
cord-350836-1enteev7	551	117	signaling	signal	VBG
cord-350836-1enteev7	551	118	Breaching	breach	VBG
cord-350836-1enteev7	551	119	self	self	NN
cord-350836-1enteev7	551	120	-	-	HYPH
cord-350836-1enteev7	551	121	tolerance	tolerance	NN
cord-350836-1enteev7	551	122	to	to	IN
cord-350836-1enteev7	552	1	Alu	Alu	NNP
cord-350836-1enteev7	552	2	duplex	duplex	NN
cord-350836-1enteev7	552	3	RNA	RNA	NNP
cord-350836-1enteev7	552	4	underlies	underlie	VBZ
cord-350836-1enteev7	553	1	MDA5-mediated	mda5-mediated	JJ
cord-350836-1enteev7	553	2	inflammation	inflammation	NN
cord-350836-1enteev7	553	3	Aicardi	Aicardi	NNPS
cord-350836-1enteev7	553	4	-	-	HYPH
cord-350836-1enteev7	553	5	Goutières	Goutières	NNP
cord-350836-1enteev7	553	6	syndrome	syndrome	NN
cord-350836-1enteev7	553	7	is	be	VBZ
cord-350836-1enteev7	553	8	caused	cause	VBN
cord-350836-1enteev7	553	9	by	by	IN
cord-350836-1enteev7	553	10	IFIH1	IFIH1	NNP
cord-350836-1enteev7	553	11	mutations	mutation	NNS
cord-350836-1enteev7	553	12	Autoimmune	autoimmune	JJ
cord-350836-1enteev7	553	13	disorders	disorder	NNS
cord-350836-1enteev7	553	14	associated	associate	VBN
cord-350836-1enteev7	553	15	with	with	IN
cord-350836-1enteev7	553	16	gain	gain	NN
cord-350836-1enteev7	553	17	of	of	IN
cord-350836-1enteev7	553	18	function	function	NN
cord-350836-1enteev7	553	19	of	of	IN
cord-350836-1enteev7	553	20	the	the	DT
cord-350836-1enteev7	553	21	intracellular	intracellular	JJ
cord-350836-1enteev7	553	22	sensor	sensor	NN
cord-350836-1enteev7	554	1	MDA5	MDA5	NNP
cord-350836-1enteev7	554	2	A	a	DT
cord-350836-1enteev7	554	3	conserved	conserved	JJ
cord-350836-1enteev7	554	4	histidine	histidine	NN
cord-350836-1enteev7	554	5	in	in	IN
cord-350836-1enteev7	554	6	the	the	DT
cord-350836-1enteev7	554	7	RNA	RNA	NNP
cord-350836-1enteev7	554	8	sensor	sensor	NN
cord-350836-1enteev7	554	9	RIG	rig	NN
cord-350836-1enteev7	555	1	-I	-i	WDT
cord-350836-1enteev7	555	2	controls	control	VBZ
cord-350836-1enteev7	555	3	immune	immune	JJ
cord-350836-1enteev7	555	4	tolerance	tolerance	NN
cord-350836-1enteev7	555	5	to	to	IN
cord-350836-1enteev7	555	6	N1	N1	NNP
cord-350836-1enteev7	555	7	-	-	HYPH
cord-350836-1enteev7	555	8	2	2	CD
cord-350836-1enteev7	555	9	′	′	CD
cord-350836-1enteev7	556	1	O	o	UH
cord-350836-1enteev7	556	2	-	-	HYPH
cord-350836-1enteev7	556	3	methylated	methylated	JJ
cord-350836-1enteev7	556	4	Self	Self	NNP
cord-350836-1enteev7	556	5	RNA	RNA	NNP
cord-350836-1enteev7	556	6	Highresolution	Highresolution	NNP
cord-350836-1enteev7	556	7	HDX	HDX	NNP
cord-350836-1enteev7	556	8	-	-	HYPH
cord-350836-1enteev7	556	9	MS	MS	NNP
cord-350836-1enteev7	556	10	reveals	reveal	VBZ
cord-350836-1enteev7	556	11	distinct	distinct	JJ
cord-350836-1enteev7	556	12	mechanisms	mechanism	NNS
cord-350836-1enteev7	556	13	of	of	IN
cord-350836-1enteev7	556	14	RNA	RNA	NNP
cord-350836-1enteev7	556	15	recognition	recognition	NN
cord-350836-1enteev7	556	16	and	and	CC
cord-350836-1enteev7	556	17	activation	activation	NN
cord-350836-1enteev7	556	18	by	by	IN
cord-350836-1enteev7	556	19	RIG	rig	NN
cord-350836-1enteev7	556	20	-	-	:
cord-350836-1enteev7	556	21	I	I	NNP
cord-350836-1enteev7	556	22	and	and	CC
cord-350836-1enteev7	556	23	MDA5	MDA5	NNP
cord-350836-1enteev7	556	24	HDX	HDX	NNP
cord-350836-1enteev7	556	25	-	-	HYPH
cord-350836-1enteev7	556	26	MS	MS	NNP
cord-350836-1enteev7	556	27	reveals	reveal	VBZ
cord-350836-1enteev7	556	28	dysregulated	dysregulated	JJ
cord-350836-1enteev7	556	29	checkpoints	checkpoint	NNS
cord-350836-1enteev7	556	30	that	that	WDT
cord-350836-1enteev7	556	31	compromise	compromise	VBP
cord-350836-1enteev7	556	32	discrimination	discrimination	NN
cord-350836-1enteev7	556	33	against	against	IN
cord-350836-1enteev7	556	34	self	self	NN
cord-350836-1enteev7	556	35	RNA	RNA	NNP
cord-350836-1enteev7	556	36	during	during	IN
cord-350836-1enteev7	556	37	RIG	rig	NN
cord-350836-1enteev7	557	1	-I	-i	DT
cord-350836-1enteev7	557	2	mediated	mediate	VBD
cord-350836-1enteev7	557	3	autoimmunity	autoimmunity	NN
cord-350836-1enteev7	557	4	ATP	ATP	NNP
cord-350836-1enteev7	557	5	hydrolysis	hydrolysis	NN
cord-350836-1enteev7	557	6	by	by	IN
cord-350836-1enteev7	557	7	the	the	DT
cord-350836-1enteev7	557	8	viral	viral	JJ
cord-350836-1enteev7	557	9	RNA	RNA	NNP
cord-350836-1enteev7	557	10	sensor	sensor	NN
cord-350836-1enteev7	557	11	RIG	rig	NN
cord-350836-1enteev7	557	12	-	-	:
cord-350836-1enteev7	557	13	I	-PRON-	PRP
cord-350836-1enteev7	557	14	prevents	prevent	VBZ
cord-350836-1enteev7	557	15	unintentional	unintentional	JJ
cord-350836-1enteev7	557	16	recognition	recognition	NN
cord-350836-1enteev7	557	17	of	of	IN
cord-350836-1enteev7	557	18	self	self	NN
cord-350836-1enteev7	557	19	-	-	HYPH
cord-350836-1enteev7	557	20	RNA	RNA	NNP
cord-350836-1enteev7	557	21	A	a	DT
cord-350836-1enteev7	557	22	brilliant	brilliant	JJ
cord-350836-1enteev7	557	23	disguise	disguise	NN
cord-350836-1enteev7	557	24	for	for	IN
cord-350836-1enteev7	557	25	self	self	NN
cord-350836-1enteev7	557	26	RNA	RNA	NNP
cord-350836-1enteev7	557	27	:	:	:
cord-350836-1enteev7	557	28	5'-end	5'-end	CD
cord-350836-1enteev7	557	29	and	and	CC
cord-350836-1enteev7	557	30	internal	internal	JJ
cord-350836-1enteev7	557	31	modifications	modification	NNS
cord-350836-1enteev7	557	32	of	of	IN
cord-350836-1enteev7	557	33	primary	primary	JJ
cord-350836-1enteev7	557	34	transcripts	transcript	NNS
cord-350836-1enteev7	557	35	suppress	suppress	VBP
cord-350836-1enteev7	557	36	elements	element	NNS
cord-350836-1enteev7	557	37	of	of	IN
cord-350836-1enteev7	557	38	innate	innate	JJ
cord-350836-1enteev7	557	39	immunity	immunity	NN
cord-350836-1enteev7	557	40	RNA	RNA	NNP
cord-350836-1enteev7	557	41	modifications	modification	NNS
cord-350836-1enteev7	557	42	go	go	VBP
cord-350836-1enteev7	557	43	viral	viral	JJ
cord-350836-1enteev7	557	44	RNAs	rna	NNS
cord-350836-1enteev7	557	45	containing	contain	VBG
cord-350836-1enteev7	557	46	modified	modify	VBN
cord-350836-1enteev7	557	47	nucleotides	nucleotide	NNS
cord-350836-1enteev7	557	48	fail	fail	VBP
cord-350836-1enteev7	557	49	to	to	TO
cord-350836-1enteev7	557	50	trigger	trigger	VB
cord-350836-1enteev7	557	51	RIG	rig	NN
cord-350836-1enteev7	557	52	-	-	:
cord-350836-1enteev7	557	53	I	-PRON-	PRP
cord-350836-1enteev7	557	54	conformational	conformational	JJ
cord-350836-1enteev7	557	55	changes	change	NNS
cord-350836-1enteev7	557	56	for	for	IN
cord-350836-1enteev7	557	57	innate	innate	JJ
cord-350836-1enteev7	557	58	immune	immune	NN
cord-350836-1enteev7	557	59	signaling	signal	VBG
cord-350836-1enteev7	557	60	Links	link	NNS
cord-350836-1enteev7	557	61	between	between	IN
cord-350836-1enteev7	557	62	recognition	recognition	NN
cord-350836-1enteev7	557	63	and	and	CC
cord-350836-1enteev7	557	64	degradation	degradation	NN
cord-350836-1enteev7	557	65	of	of	IN
cord-350836-1enteev7	557	66	cytoplasmic	cytoplasmic	JJ
cord-350836-1enteev7	557	67	viral	viral	JJ
cord-350836-1enteev7	557	68	RNA	RNA	NNP
cord-350836-1enteev7	557	69	in	in	IN
cord-350836-1enteev7	557	70	innate	innate	JJ
cord-350836-1enteev7	557	71	immune	immune	JJ
cord-350836-1enteev7	557	72	response	response	NN
cord-350836-1enteev7	558	1	LGP2	LGP2	NNP
cord-350836-1enteev7	558	2	is	be	VBZ
cord-350836-1enteev7	558	3	a	a	DT
cord-350836-1enteev7	558	4	positive	positive	JJ
cord-350836-1enteev7	558	5	regulator	regulator	NN
cord-350836-1enteev7	558	6	of	of	IN
cord-350836-1enteev7	558	7	RIG	rig	NN
cord-350836-1enteev7	558	8	-	-	HYPH
cord-350836-1enteev7	558	9	I	I	NNP
cord-350836-1enteev7	558	10	-	-	HYPH
cord-350836-1enteev7	558	11	and	and	CC
cord-350836-1enteev7	558	12	MDA5-mediated	MDA5-mediated	NNP
cord-350836-1enteev7	558	13	antiviral	antiviral	JJ
cord-350836-1enteev7	558	14	responses	response	NNS
cord-350836-1enteev7	559	1	The	the	DT
cord-350836-1enteev7	559	2	RIG	rig	NN
cord-350836-1enteev7	559	3	-	-	:
cord-350836-1enteev7	559	4	I	-PRON-	PRP
cord-350836-1enteev7	559	5	ATPase	ATPase	NNP
cord-350836-1enteev7	559	6	domain	domain	NN
cord-350836-1enteev7	559	7	structure	structure	NN
cord-350836-1enteev7	559	8	reveals	reveal	VBZ
cord-350836-1enteev7	559	9	insights	insight	NNS
cord-350836-1enteev7	559	10	into	into	IN
cord-350836-1enteev7	559	11	ATP	ATP	NNP
cord-350836-1enteev7	559	12	-	-	HYPH
cord-350836-1enteev7	559	13	dependent	dependent	JJ
cord-350836-1enteev7	559	14	antiviral	antiviral	JJ
cord-350836-1enteev7	559	15	signalling	signal	VBG
cord-350836-1enteev7	559	16	Kinetic	kinetic	JJ
cord-350836-1enteev7	559	17	discrimination	discrimination	NN
cord-350836-1enteev7	559	18	of	of	IN
cord-350836-1enteev7	559	19	self	self	NN
cord-350836-1enteev7	559	20	/	/	SYM
cord-350836-1enteev7	559	21	non	non	JJ
cord-350836-1enteev7	559	22	-	-	JJ
cord-350836-1enteev7	559	23	self	self	JJ
cord-350836-1enteev7	559	24	RNA	RNA	NNP
cord-350836-1enteev7	559	25	by	by	IN
cord-350836-1enteev7	559	26	the	the	DT
cord-350836-1enteev7	559	27	ATPase	ATPase	NNP
cord-350836-1enteev7	559	28	activity	activity	NN
cord-350836-1enteev7	559	29	of	of	IN
cord-350836-1enteev7	559	30	RIG	rig	NN
cord-350836-1enteev7	559	31	-	-	:
cord-350836-1enteev7	559	32	I	I	NNP
cord-350836-1enteev7	559	33	and	and	CC
cord-350836-1enteev7	559	34	MDA5	MDA5	NNP
cord-350836-1enteev7	559	35	Cryo	Cryo	NNP
cord-350836-1enteev7	559	36	-	-	HYPH
cord-350836-1enteev7	559	37	EM	EM	NNP
cord-350836-1enteev7	559	38	structures	structure	NNS
cord-350836-1enteev7	559	39	of	of	IN
cord-350836-1enteev7	559	40	MDA5-dsRNA	MDA5-dsRNA	NNP
cord-350836-1enteev7	559	41	filaments	filament	NNS
cord-350836-1enteev7	559	42	at	at	IN
cord-350836-1enteev7	559	43	different	different	JJ
cord-350836-1enteev7	559	44	stages	stage	NNS
cord-350836-1enteev7	559	45	of	of	IN
cord-350836-1enteev7	559	46	ATP	ATP	NNP
cord-350836-1enteev7	559	47	hydrolysis	hydrolysis	NN
cord-350836-1enteev7	559	48	Circular	Circular	NNP
cord-350836-1enteev7	559	49	RNAs	rna	NNS
cord-350836-1enteev7	559	50	:	:	:
cord-350836-1enteev7	559	51	a	a	DT
cord-350836-1enteev7	559	52	novel	novel	JJ
cord-350836-1enteev7	559	53	type	type	NN
cord-350836-1enteev7	559	54	of	of	IN
cord-350836-1enteev7	559	55	non	non	JJ
cord-350836-1enteev7	559	56	-	-	JJ
cord-350836-1enteev7	559	57	coding	coding	JJ
cord-350836-1enteev7	559	58	RNA	rna	NN
cord-350836-1enteev7	559	59	and	and	CC
cord-350836-1enteev7	559	60	their	-PRON-	PRP$
cord-350836-1enteev7	559	61	potential	potential	JJ
cord-350836-1enteev7	559	62	implications	implication	NNS
cord-350836-1enteev7	559	63	in	in	IN
cord-350836-1enteev7	559	64	antiviral	antiviral	JJ
cord-350836-1enteev7	559	65	immunity	immunity	NN
cord-350836-1enteev7	559	66	Sensing	Sensing	NNP
cord-350836-1enteev7	559	67	self	self	NN
cord-350836-1enteev7	559	68	and	and	CC
cord-350836-1enteev7	559	69	foreign	foreign	JJ
cord-350836-1enteev7	559	70	circular	circular	JJ
cord-350836-1enteev7	559	71	RNAs	rna	NNS
cord-350836-1enteev7	559	72	by	by	IN
cord-350836-1enteev7	559	73	intron	intron	NN
cord-350836-1enteev7	559	74	identity	identity	NN
cord-350836-1enteev7	560	1	The	the	DT
cord-350836-1enteev7	560	2	SKIV2L	SKIV2L	NNP
cord-350836-1enteev7	560	3	RNA	RNA	NNP
cord-350836-1enteev7	560	4	exosome	exosome	NNP
cord-350836-1enteev7	560	5	limits	limit	VBZ
cord-350836-1enteev7	560	6	activation	activation	NN
cord-350836-1enteev7	560	7	of	of	IN
cord-350836-1enteev7	560	8	the	the	DT
cord-350836-1enteev7	560	9	RIG	rig	NN
cord-350836-1enteev7	560	10	-	-	HYPH
cord-350836-1enteev7	560	11	I	i	NN
cord-350836-1enteev7	560	12	-	-	HYPH
cord-350836-1enteev7	560	13	like	like	JJ
cord-350836-1enteev7	560	14	receptors	receptor	NNS
cord-350836-1enteev7	560	15	Induction	Induction	NNP
cord-350836-1enteev7	560	16	of	of	IN
cord-350836-1enteev7	560	17	selenoprotein	selenoprotein	NNP
cord-350836-1enteev7	560	18	P	P	NNP
cord-350836-1enteev7	560	19	mRNA	mrna	NN
cord-350836-1enteev7	560	20	during	during	IN
cord-350836-1enteev7	561	1	hepatitis	hepatitis	NNP
cord-350836-1enteev7	561	2	C	C	NNP
cord-350836-1enteev7	561	3	virus	virus	NN
cord-350836-1enteev7	561	4	infection	infection	NN
cord-350836-1enteev7	561	5	inhibits	inhibit	VBZ
cord-350836-1enteev7	561	6	RIG	rig	NN
cord-350836-1enteev7	561	7	-	-	HYPH
cord-350836-1enteev7	561	8	I	i	NN
cord-350836-1enteev7	561	9	-	-	HYPH
cord-350836-1enteev7	561	10	mediated	mediate	VBN
cord-350836-1enteev7	561	11	antiviral	antiviral	JJ
cord-350836-1enteev7	561	12	immunity	immunity	NN
cord-350836-1enteev7	561	13	Human	human	JJ
cord-350836-1enteev7	561	14	long	long	JJ
cord-350836-1enteev7	561	15	non	non	JJ
cord-350836-1enteev7	561	16	-	-	JJ
cord-350836-1enteev7	561	17	coding	coding	JJ
cord-350836-1enteev7	561	18	RNA	RNA	NNP
cord-350836-1enteev7	561	19	LncATV	LncATV	NNP
cord-350836-1enteev7	561	20	promotes	promote	VBZ
cord-350836-1enteev7	561	21	viral	viral	JJ
cord-350836-1enteev7	561	22	replication	replication	NN
cord-350836-1enteev7	561	23	by	by	IN
cord-350836-1enteev7	561	24	restricting	restrict	VBG
cord-350836-1enteev7	561	25	RIG	rig	NN
cord-350836-1enteev7	561	26	-	-	HYPH
cord-350836-1enteev7	561	27	I	i	NN
cord-350836-1enteev7	561	28	-	-	HYPH
cord-350836-1enteev7	561	29	mediated	mediate	VBN
cord-350836-1enteev7	561	30	innate	innate	JJ
cord-350836-1enteev7	561	31	immunity	immunity	NN
cord-350836-1enteev7	561	32	Immunostimulatory	Immunostimulatory	NNP
cord-350836-1enteev7	561	33	effects	effect	NNS
cord-350836-1enteev7	561	34	triggered	trigger	VBN
cord-350836-1enteev7	561	35	by	by	IN
cord-350836-1enteev7	561	36	self	self	NN
cord-350836-1enteev7	561	37	-	-	HYPH
cord-350836-1enteev7	561	38	assembled	assemble	VBN
cord-350836-1enteev7	561	39	microspheres	microsphere	NNS
cord-350836-1enteev7	561	40	with	with	IN
cord-350836-1enteev7	561	41	tandem	tandem	NN
cord-350836-1enteev7	561	42	repeats	repeat	NNS
cord-350836-1enteev7	561	43	of	of	IN
cord-350836-1enteev7	561	44	polymerized	polymerize	VBN
cord-350836-1enteev7	561	45	RNA	RNA	NNP
cord-350836-1enteev7	561	46	strands	strand	NNS
cord-350836-1enteev7	561	47	LINE1	LINE1	NNP
cord-350836-1enteev7	561	48	contributes	contribute	VBZ
cord-350836-1enteev7	561	49	to	to	IN
cord-350836-1enteev7	561	50	autoimmunity	autoimmunity	NN
cord-350836-1enteev7	561	51	through	through	IN
cord-350836-1enteev7	561	52	both	both	DT
cord-350836-1enteev7	561	53	RIG	rig	NN
cord-350836-1enteev7	561	54	-	-	HYPH
cord-350836-1enteev7	561	55	I	I	NNP
cord-350836-1enteev7	561	56	-	-	HYPH
cord-350836-1enteev7	561	57	and	and	CC
cord-350836-1enteev7	561	58	MDA5-mediated	MDA5-mediated	NNP
cord-350836-1enteev7	561	59	RNA	RNA	NNP
cord-350836-1enteev7	561	60	sensing	sense	VBG
cord-350836-1enteev7	561	61	pathways	pathway	NNS
cord-350836-1enteev7	562	1	Viral	viral	JJ
cord-350836-1enteev7	562	2	unmasking	unmasking	NN
cord-350836-1enteev7	562	3	of	of	IN
cord-350836-1enteev7	562	4	cellular	cellular	JJ
cord-350836-1enteev7	562	5	5S	5S	NNP
cord-350836-1enteev7	562	6	rRNA	rRNA	NNP
cord-350836-1enteev7	562	7	pseudogene	pseudogene	NNP
cord-350836-1enteev7	562	8	transcripts	transcript	NNS
cord-350836-1enteev7	562	9	induces	induce	VBZ
cord-350836-1enteev7	562	10	RIG	rig	NN
cord-350836-1enteev7	562	11	-	-	HYPH
cord-350836-1enteev7	562	12	I	i	NN
cord-350836-1enteev7	562	13	-	-	HYPH
cord-350836-1enteev7	562	14	mediated	mediate	VBN
cord-350836-1enteev7	562	15	immunity	immunity	NN
cord-350836-1enteev7	562	16	Mitochondrial	mitochondrial	JJ
cord-350836-1enteev7	562	17	dynamics	dynamic	NNS
cord-350836-1enteev7	562	18	and	and	CC
cord-350836-1enteev7	562	19	viral	viral	JJ
cord-350836-1enteev7	562	20	infections	infection	NNS
cord-350836-1enteev7	562	21	:	:	:
cord-350836-1enteev7	562	22	a	a	DT
cord-350836-1enteev7	562	23	close	close	JJ
cord-350836-1enteev7	562	24	nexus	nexus	NN
cord-350836-1enteev7	562	25	Mitochondrial	mitochondrial	JJ
cord-350836-1enteev7	562	26	double	double	RB
cord-350836-1enteev7	562	27	-	-	HYPH
cord-350836-1enteev7	562	28	stranded	strand	VBN
cord-350836-1enteev7	562	29	RNA	rna	NN
cord-350836-1enteev7	562	30	triggers	trigger	NNS
cord-350836-1enteev7	562	31	antiviral	antiviral	JJ
cord-350836-1enteev7	562	32	signalling	signal	VBG
cord-350836-1enteev7	562	33	in	in	IN
cord-350836-1enteev7	563	1	humans	human	NNS
cord-350836-1enteev7	563	2	Apoptotic	apoptotic	JJ
cord-350836-1enteev7	563	3	endothelial	endothelial	JJ
cord-350836-1enteev7	563	4	cells	cell	NNS
cord-350836-1enteev7	563	5	release	release	VBP
cord-350836-1enteev7	563	6	small	small	JJ
cord-350836-1enteev7	563	7	extracellular	extracellular	JJ
cord-350836-1enteev7	563	8	vesicles	vesicle	NNS
cord-350836-1enteev7	563	9	loaded	load	VBN
cord-350836-1enteev7	563	10	with	with	IN
cord-350836-1enteev7	563	11	immunostimulatory	immunostimulatory	JJ
cord-350836-1enteev7	563	12	viral	viral	JJ
cord-350836-1enteev7	563	13	-	-	:
cord-350836-1enteev7	563	14	like	like	JJ
cord-350836-1enteev7	563	15	Interferons	interferon	NNS
cord-350836-1enteev7	563	16	and	and	CC
cord-350836-1enteev7	563	17	viruses	virus	NNS
cord-350836-1enteev7	563	18	:	:	:
cord-350836-1enteev7	563	19	an	an	DT
cord-350836-1enteev7	563	20	evolutionary	evolutionary	JJ
cord-350836-1enteev7	563	21	arms	arm	NNS
cord-350836-1enteev7	563	22	race	race	NN
cord-350836-1enteev7	563	23	of	of	IN
cord-350836-1enteev7	563	24	molecular	molecular	JJ
cord-350836-1enteev7	563	25	interactions	interaction	NNS
cord-350836-1enteev7	563	26	Viral	viral	JJ
cord-350836-1enteev7	563	27	evasion	evasion	NN
cord-350836-1enteev7	563	28	strategies	strategy	NNS
cord-350836-1enteev7	563	29	in	in	IN
cord-350836-1enteev7	563	30	type	type	NN
cord-350836-1enteev7	564	1	I	-PRON-	PRP
cord-350836-1enteev7	564	2	IFN	IFN	NNP
cord-350836-1enteev7	564	3	signaling	signal	VBG
cord-350836-1enteev7	564	4	-a	-a	:
cord-350836-1enteev7	564	5	summary	summary	NN
cord-350836-1enteev7	564	6	of	of	IN
cord-350836-1enteev7	564	7	recent	recent	JJ
cord-350836-1enteev7	564	8	developments	development	NNS
cord-350836-1enteev7	564	9	Viral	viral	JJ
cord-350836-1enteev7	564	10	evasion	evasion	NN
cord-350836-1enteev7	564	11	of	of	IN
cord-350836-1enteev7	564	12	intracellular	intracellular	JJ
cord-350836-1enteev7	564	13	DNA	DNA	NNP
cord-350836-1enteev7	564	14	and	and	CC
cord-350836-1enteev7	564	15	RNA	RNA	NNP
cord-350836-1enteev7	564	16	sensing	sense	VBG
cord-350836-1enteev7	564	17	Ten	ten	CD
cord-350836-1enteev7	564	18	strategies	strategy	NNS
cord-350836-1enteev7	564	19	of	of	IN
cord-350836-1enteev7	564	20	interferon	interferon	NN
cord-350836-1enteev7	564	21	evasion	evasion	NN
cord-350836-1enteev7	564	22	by	by	IN
cord-350836-1enteev7	564	23	viruses	virus	NNS
cord-350836-1enteev7	565	1	Segmented	segmented	JJ
cord-350836-1enteev7	565	2	negative	negative	JJ
cord-350836-1enteev7	565	3	-	-	HYPH
cord-350836-1enteev7	565	4	strand	strand	NN
cord-350836-1enteev7	565	5	RNA	RNA	NNP
cord-350836-1enteev7	565	6	viruses	virus	NNS
cord-350836-1enteev7	565	7	and	and	CC
cord-350836-1enteev7	565	8	RIG	rig	NN
cord-350836-1enteev7	566	1	-I	-i	DT
cord-350836-1enteev7	566	2	:	:	:
cord-350836-1enteev7	566	3	divide	divide	VB
cord-350836-1enteev7	566	4	(	(	-LRB-
cord-350836-1enteev7	566	5	your	-PRON-	PRP$
cord-350836-1enteev7	566	6	genome	genome	NN
cord-350836-1enteev7	566	7	)	)	-RRB-
cord-350836-1enteev7	566	8	and	and	CC
cord-350836-1enteev7	566	9	rule	rule	VB
cord-350836-1enteev7	566	10	Influenza	Influenza	NNP
cord-350836-1enteev7	566	11	A	A	NNP
cord-350836-1enteev7	566	12	:	:	:
cord-350836-1enteev7	566	13	understanding	understand	VBG
cord-350836-1enteev7	566	14	the	the	DT
cord-350836-1enteev7	566	15	viral	viral	JJ
cord-350836-1enteev7	566	16	life	life	NN
cord-350836-1enteev7	566	17	cycle	cycle	NN
cord-350836-1enteev7	566	18	Nuclear	Nuclear	NNP
cord-350836-1enteev7	566	19	-	-	HYPH
cord-350836-1enteev7	566	20	resident	resident	NN
cord-350836-1enteev7	566	21	RIG	rig	NN
cord-350836-1enteev7	567	1	-I	-i	WDT
cord-350836-1enteev7	567	2	senses	sense	VBZ
cord-350836-1enteev7	567	3	viral	viral	JJ
cord-350836-1enteev7	567	4	replication	replication	NN
cord-350836-1enteev7	567	5	inducing	induce	VBG
cord-350836-1enteev7	567	6	antiviral	antiviral	JJ
cord-350836-1enteev7	567	7	immunity	immunity	NN
cord-350836-1enteev7	567	8	Processing	processing	NN
cord-350836-1enteev7	567	9	of	of	IN
cord-350836-1enteev7	567	10	genome	genome	NN
cord-350836-1enteev7	567	11	5	5	CD
cord-350836-1enteev7	567	12	′	′	CD
cord-350836-1enteev7	567	13	termini	terminus	NNS
cord-350836-1enteev7	567	14	as	as	IN
cord-350836-1enteev7	567	15	a	a	DT
cord-350836-1enteev7	567	16	strategy	strategy	NN
cord-350836-1enteev7	567	17	of	of	IN
cord-350836-1enteev7	567	18	negative	negative	JJ
cord-350836-1enteev7	567	19	-	-	HYPH
cord-350836-1enteev7	567	20	strand	strand	NN
cord-350836-1enteev7	567	21	RNA	RNA	NNP
cord-350836-1enteev7	567	22	viruses	virus	NNS
cord-350836-1enteev7	567	23	to	to	TO
cord-350836-1enteev7	567	24	avoid	avoid	VB
cord-350836-1enteev7	567	25	RIG	rig	NN
cord-350836-1enteev7	567	26	-	-	HYPH
cord-350836-1enteev7	567	27	I	i	NN
cord-350836-1enteev7	567	28	-	-	HYPH
cord-350836-1enteev7	567	29	dependent	dependent	JJ
cord-350836-1enteev7	567	30	interferon	interferon	NN
cord-350836-1enteev7	567	31	induction	induction	NN
cord-350836-1enteev7	568	1	The	the	DT
cord-350836-1enteev7	568	2	microRNA	microRNA	NNP
cord-350836-1enteev7	568	3	miR-485	miR-485	NNP
cord-350836-1enteev7	568	4	targets	targets	NNP
cord-350836-1enteev7	568	5	host	host	NN
cord-350836-1enteev7	568	6	and	and	CC
cord-350836-1enteev7	568	7	influenza	influenza	NN
cord-350836-1enteev7	568	8	virus	virus	NN
cord-350836-1enteev7	568	9	transcripts	transcript	NNS
cord-350836-1enteev7	568	10	to	to	TO
cord-350836-1enteev7	568	11	regulate	regulate	VB
cord-350836-1enteev7	568	12	antiviral	antiviral	JJ
cord-350836-1enteev7	568	13	immunity	immunity	NN
cord-350836-1enteev7	568	14	and	and	CC
cord-350836-1enteev7	568	15	restrict	restrict	VB
cord-350836-1enteev7	568	16	viral	viral	JJ
cord-350836-1enteev7	568	17	replication	replication	NN
cord-350836-1enteev7	568	18	A	a	DT
cord-350836-1enteev7	568	19	single	single	JJ
cord-350836-1enteev7	568	20	amino	amino	NN
cord-350836-1enteev7	568	21	acid	acid	NN
cord-350836-1enteev7	568	22	substitution	substitution	NN
cord-350836-1enteev7	568	23	within	within	IN
cord-350836-1enteev7	568	24	the	the	DT
cord-350836-1enteev7	568	25	paramyxovirus	paramyxovirus	NNP
cord-350836-1enteev7	568	26	sendai	sendai	NNP
cord-350836-1enteev7	568	27	virus	virus	NN
cord-350836-1enteev7	568	28	nucleoprotein	nucleoprotein	NNP
cord-350836-1enteev7	568	29	is	be	VBZ
cord-350836-1enteev7	568	30	a	a	DT
cord-350836-1enteev7	568	31	critical	critical	JJ
cord-350836-1enteev7	568	32	determinant	determinant	NN
cord-350836-1enteev7	568	33	for	for	IN
cord-350836-1enteev7	568	34	production	production	NN
cord-350836-1enteev7	568	35	of	of	IN
cord-350836-1enteev7	568	36	interferon	interferon	NN
cord-350836-1enteev7	568	37	-	-	HYPH
cord-350836-1enteev7	568	38	betainducing	betainduce	VBG
cord-350836-1enteev7	568	39	copyback	copyback	NN
cord-350836-1enteev7	568	40	-	-	HYPH
cord-350836-1enteev7	568	41	type	type	NN
cord-350836-1enteev7	568	42	defective	defective	JJ
cord-350836-1enteev7	568	43	interfering	interfere	VBG
cord-350836-1enteev7	568	44	genomes	genome	NNS
cord-350836-1enteev7	568	45	Mini	mini	JJ
cord-350836-1enteev7	568	46	viral	viral	JJ
cord-350836-1enteev7	568	47	RNAs	rna	NNS
cord-350836-1enteev7	568	48	act	act	VBP
cord-350836-1enteev7	568	49	as	as	IN
cord-350836-1enteev7	568	50	innate	innate	JJ
cord-350836-1enteev7	568	51	immune	immune	JJ
cord-350836-1enteev7	568	52	agonists	agonist	NNS
cord-350836-1enteev7	568	53	during	during	IN
cord-350836-1enteev7	568	54	influenza	influenza	NN
cord-350836-1enteev7	568	55	virus	virus	NN
cord-350836-1enteev7	568	56	infection	infection	NN
cord-350836-1enteev7	568	57	RIG	rig	NN
cord-350836-1enteev7	568	58	-	-	:
cord-350836-1enteev7	568	59	I	I	NNP
cord-350836-1enteev7	568	60	and	and	CC
cord-350836-1enteev7	568	61	MDA-5	MDA-5	NNP
cord-350836-1enteev7	568	62	detection	detection	NN
cord-350836-1enteev7	568	63	of	of	IN
cord-350836-1enteev7	568	64	viral	viral	JJ
cord-350836-1enteev7	568	65	RNA	RNA	NNP
cord-350836-1enteev7	568	66	-	-	HYPH
cord-350836-1enteev7	568	67	dependent	dependent	JJ
cord-350836-1enteev7	568	68	RNA	RNA	NNP
cord-350836-1enteev7	568	69	polymerase	polymerase	NN
cord-350836-1enteev7	568	70	activity	activity	NN
cord-350836-1enteev7	568	71	restricts	restrict	VBZ
cord-350836-1enteev7	568	72	positive	positive	JJ
cord-350836-1enteev7	568	73	-	-	HYPH
cord-350836-1enteev7	568	74	strand	strand	NN
cord-350836-1enteev7	568	75	RNA	RNA	NNP
cord-350836-1enteev7	568	76	virus	virus	NN
cord-350836-1enteev7	568	77	replication	replication	NN
cord-350836-1enteev7	568	78	Visualization	visualization	NN
cord-350836-1enteev7	568	79	of	of	IN
cord-350836-1enteev7	568	80	arenavirus	arenavirus	NNP
cord-350836-1enteev7	568	81	RNA	RNA	NNP
cord-350836-1enteev7	568	82	species	specie	NNS
cord-350836-1enteev7	568	83	in	in	IN
cord-350836-1enteev7	568	84	individual	individual	JJ
cord-350836-1enteev7	568	85	cells	cell	NNS
cord-350836-1enteev7	568	86	by	by	IN
cord-350836-1enteev7	568	87	singlemolecule	singlemolecule	JJ
cord-350836-1enteev7	568	88	fluorescence	fluorescence	NN
cord-350836-1enteev7	568	89	in	in	IN
cord-350836-1enteev7	568	90	situ	situ	NN
cord-350836-1enteev7	568	91	hybridization	hybridization	NN
cord-350836-1enteev7	568	92	(	(	-LRB-
cord-350836-1enteev7	568	93	smFISH	smFISH	NNP
cord-350836-1enteev7	568	94	)	)	-RRB-
cord-350836-1enteev7	569	1	suggests	suggest	VBZ
cord-350836-1enteev7	569	2	a	a	DT
cord-350836-1enteev7	569	3	model	model	NN
cord-350836-1enteev7	569	4	of	of	IN
cord-350836-1enteev7	569	5	cyclical	cyclical	JJ
cord-350836-1enteev7	569	6	infection	infection	NN
cord-350836-1enteev7	569	7	and	and	CC
cord-350836-1enteev7	569	8	clearance	clearance	NN
cord-350836-1enteev7	569	9	during	during	IN
cord-350836-1enteev7	569	10	persistence	persistence	NN
cord-350836-1enteev7	569	11	Structure	Structure	NNP
cord-350836-1enteev7	569	12	of	of	IN
cord-350836-1enteev7	569	13	the	the	DT
cord-350836-1enteev7	569	14	Lassa	Lassa	NNP
cord-350836-1enteev7	569	15	virus	virus	NN
cord-350836-1enteev7	569	16	nucleoprotein	nucleoprotein	NNP
cord-350836-1enteev7	569	17	reveals	reveal	VBZ
cord-350836-1enteev7	569	18	a	a	DT
cord-350836-1enteev7	569	19	dsRNA	dsrna	JJ
cord-350836-1enteev7	569	20	-	-	HYPH
cord-350836-1enteev7	569	21	specific	specific	JJ
cord-350836-1enteev7	569	22	3	3	CD
cord-350836-1enteev7	569	23	'	'	''
cord-350836-1enteev7	569	24	to	to	IN
cord-350836-1enteev7	569	25	5	5	CD
cord-350836-1enteev7	569	26	'	'	''
cord-350836-1enteev7	569	27	exonuclease	exonuclease	NN
cord-350836-1enteev7	569	28	activity	activity	NN
cord-350836-1enteev7	569	29	essential	essential	JJ
cord-350836-1enteev7	569	30	for	for	IN
cord-350836-1enteev7	569	31	immune	immune	JJ
cord-350836-1enteev7	569	32	suppression	suppression	NN
cord-350836-1enteev7	570	1	In	in	IN
cord-350836-1enteev7	570	2	vitro	vitro	FW
cord-350836-1enteev7	570	3	and	and	CC
cord-350836-1enteev7	570	4	in	in	IN
cord-350836-1enteev7	570	5	vivo	vivo	FW
cord-350836-1enteev7	570	6	characterizations	characterization	NNS
cord-350836-1enteev7	570	7	of	of	IN
cord-350836-1enteev7	570	8	pichinde	pichinde	NNP
cord-350836-1enteev7	570	9	viral	viral	NNP
cord-350836-1enteev7	570	10	nucleoprotein	nucleoprotein	NNP
cord-350836-1enteev7	570	11	exoribonuclease	exoribonuclease	NNP
cord-350836-1enteev7	570	12	functions	function	VBZ
cord-350836-1enteev7	570	13	Structural	structural	JJ
cord-350836-1enteev7	570	14	basis	basis	NN
cord-350836-1enteev7	570	15	and	and	CC
cord-350836-1enteev7	570	16	functional	functional	JJ
cord-350836-1enteev7	570	17	analysis	analysis	NN
cord-350836-1enteev7	570	18	of	of	IN
cord-350836-1enteev7	570	19	the	the	DT
cord-350836-1enteev7	570	20	SARS	SARS	NNP
cord-350836-1enteev7	570	21	coronavirus	coronavirus	NN
cord-350836-1enteev7	570	22	nsp14-nsp10	nsp14-nsp10	RB
cord-350836-1enteev7	570	23	complex	complex	JJ
cord-350836-1enteev7	570	24	Characterization	characterization	NN
cord-350836-1enteev7	570	25	of	of	IN
cord-350836-1enteev7	570	26	a	a	DT
cord-350836-1enteev7	570	27	bafinivirus	bafinivirus	NN
cord-350836-1enteev7	570	28	exoribonuclease	exoribonuclease	NN
cord-350836-1enteev7	570	29	activity	activity	NN
cord-350836-1enteev7	570	30	Regulation	Regulation	NNP
cord-350836-1enteev7	570	31	of	of	IN
cord-350836-1enteev7	570	32	RIG	rig	NN
cord-350836-1enteev7	570	33	-	-	HYPH
cord-350836-1enteev7	570	34	I	i	NN
cord-350836-1enteev7	570	35	-	-	HYPH
cord-350836-1enteev7	570	36	like	like	JJ
cord-350836-1enteev7	570	37	receptor	receptor	NN
cord-350836-1enteev7	570	38	signaling	signal	VBG
cord-350836-1enteev7	570	39	by	by	IN
cord-350836-1enteev7	570	40	host	host	NN
cord-350836-1enteev7	570	41	and	and	CC
cord-350836-1enteev7	570	42	viral	viral	JJ
cord-350836-1enteev7	570	43	proteins	protein	NNS
cord-350836-1enteev7	570	44	Human	human	JJ
cord-350836-1enteev7	570	45	respiratory	respiratory	JJ
cord-350836-1enteev7	570	46	syncytial	syncytial	JJ
cord-350836-1enteev7	570	47	virus	virus	NN
cord-350836-1enteev7	570	48	non	non	JJ
cord-350836-1enteev7	570	49	-	-	JJ
cord-350836-1enteev7	570	50	structural	structural	JJ
cord-350836-1enteev7	570	51	protein	protein	NN
cord-350836-1enteev7	570	52	NS2	NS2	NNP
cord-350836-1enteev7	570	53	antagonizes	antagonize	VBZ
cord-350836-1enteev7	570	54	the	the	DT
cord-350836-1enteev7	570	55	activation	activation	NN
cord-350836-1enteev7	570	56	of	of	IN
cord-350836-1enteev7	570	57	beta	beta	NN
cord-350836-1enteev7	570	58	interferon	interferon	NN
cord-350836-1enteev7	570	59	transcription	transcription	NN
cord-350836-1enteev7	570	60	by	by	IN
cord-350836-1enteev7	570	61	interacting	interact	VBG
cord-350836-1enteev7	570	62	with	with	IN
cord-350836-1enteev7	570	63	RIG	rig	NN
cord-350836-1enteev7	570	64	-	-	:
cord-350836-1enteev7	570	65	I	i	NN
cord-350836-1enteev7	571	1	The	the	DT
cord-350836-1enteev7	571	2	Z	z	NN
cord-350836-1enteev7	571	3	proteins	protein	NNS
cord-350836-1enteev7	571	4	of	of	IN
cord-350836-1enteev7	571	5	pathogenic	pathogenic	JJ
cord-350836-1enteev7	571	6	but	but	CC
cord-350836-1enteev7	571	7	not	not	RB
cord-350836-1enteev7	571	8	non	non	JJ
cord-350836-1enteev7	571	9	-	-	JJ
cord-350836-1enteev7	571	10	pathogenic	pathogenic	JJ
cord-350836-1enteev7	571	11	arenaviruses	arenavirus	NNS
cord-350836-1enteev7	571	12	inhibit	inhibit	VBP
cord-350836-1enteev7	571	13	RIG	rig	NN
cord-350836-1enteev7	571	14	-	-	HYPH
cord-350836-1enteev7	571	15	i	i	PRP
cord-350836-1enteev7	571	16	-	-	HYPH
cord-350836-1enteev7	571	17	like	like	JJ
cord-350836-1enteev7	571	18	receptor	receptor	NN
cord-350836-1enteev7	571	19	-	-	HYPH
cord-350836-1enteev7	571	20	dependent	dependent	JJ
cord-350836-1enteev7	571	21	interferon	interferon	NN
cord-350836-1enteev7	571	22	production	production	NN
cord-350836-1enteev7	571	23	A	a	DT
cord-350836-1enteev7	571	24	viral	viral	JJ
cord-350836-1enteev7	571	25	deamidase	deamidase	NN
cord-350836-1enteev7	571	26	targets	target	VBZ
cord-350836-1enteev7	571	27	the	the	DT
cord-350836-1enteev7	571	28	helicase	helicase	NN
cord-350836-1enteev7	571	29	domain	domain	NN
cord-350836-1enteev7	571	30	of	of	IN
cord-350836-1enteev7	571	31	RIG	rig	NN
cord-350836-1enteev7	571	32	-	-	:
cord-350836-1enteev7	571	33	I	i	NN
cord-350836-1enteev7	571	34	to	to	TO
cord-350836-1enteev7	571	35	block	block	VB
cord-350836-1enteev7	571	36	RNA	RNA	NNP
cord-350836-1enteev7	571	37	-	-	HYPH
cord-350836-1enteev7	571	38	induced	induce	VBN
cord-350836-1enteev7	571	39	activation	activation	NN
cord-350836-1enteev7	571	40	Interactions	interaction	NNS
cord-350836-1enteev7	571	41	between	between	IN
cord-350836-1enteev7	571	42	the	the	DT
cord-350836-1enteev7	571	43	Influenza	Influenza	NNP
cord-350836-1enteev7	571	44	A	A	NNP
cord-350836-1enteev7	571	45	virus	virus	NN
cord-350836-1enteev7	571	46	RNA	rna	NN
cord-350836-1enteev7	571	47	polymerase	polymerase	NN
cord-350836-1enteev7	571	48	components	component	NNS
cord-350836-1enteev7	571	49	and	and	CC
cord-350836-1enteev7	571	50	retinoic	retinoic	JJ
cord-350836-1enteev7	571	51	acid	acid	NN
cord-350836-1enteev7	571	52	-	-	HYPH
cord-350836-1enteev7	571	53	inducible	inducible	JJ
cord-350836-1enteev7	571	54	gene	gene	NN
cord-350836-1enteev7	571	55	I	-PRON-	PRP
cord-350836-1enteev7	571	56	Exonuclease	Exonuclease	NNP
cord-350836-1enteev7	571	57	domain	domain	NN
cord-350836-1enteev7	571	58	of	of	IN
cord-350836-1enteev7	571	59	the	the	DT
cord-350836-1enteev7	571	60	Lassa	Lassa	NNP
cord-350836-1enteev7	571	61	virus	virus	NN
cord-350836-1enteev7	571	62	nucleoprotein	nucleoprotein	NNP
cord-350836-1enteev7	572	1	is	be	VBZ
cord-350836-1enteev7	572	2	critical	critical	JJ
cord-350836-1enteev7	572	3	to	to	TO
cord-350836-1enteev7	572	4	avoid	avoid	VB
cord-350836-1enteev7	572	5	RIG	rig	NN
cord-350836-1enteev7	573	1	-I	-i	DT
cord-350836-1enteev7	573	2	signaling	signal	VBG
cord-350836-1enteev7	573	3	and	and	CC
cord-350836-1enteev7	573	4	to	to	TO
cord-350836-1enteev7	573	5	inhibit	inhibit	VB
cord-350836-1enteev7	573	6	the	the	DT
cord-350836-1enteev7	573	7	innate	innate	JJ
cord-350836-1enteev7	573	8	immune	immune	JJ
cord-350836-1enteev7	573	9	response	response	NN
cord-350836-1enteev7	573	10	Arenaviral	Arenaviral	NNP
cord-350836-1enteev7	573	11	nucleoproteins	nucleoprotein	NNS
cord-350836-1enteev7	573	12	suppress	suppress	VBP
cord-350836-1enteev7	573	13	PACT	pact	NN
cord-350836-1enteev7	573	14	-	-	HYPH
cord-350836-1enteev7	573	15	induced	induce	VBN
cord-350836-1enteev7	573	16	augmentation	augmentation	NN
cord-350836-1enteev7	573	17	of	of	IN
cord-350836-1enteev7	573	18	RIG	rig	NN
cord-350836-1enteev7	574	1	-I	-i	WDT
cord-350836-1enteev7	574	2	function	function	NN
cord-350836-1enteev7	574	3	to	to	TO
cord-350836-1enteev7	574	4	inhibit	inhibit	VB
cord-350836-1enteev7	574	5	type	type	NN
cord-350836-1enteev7	575	1	I	-PRON-	PRP
cord-350836-1enteev7	575	2	interferon	interferon	VBD
cord-350836-1enteev7	575	3	production	production	NN
cord-350836-1enteev7	576	1	Rotavirus	rotavirus	JJ
cord-350836-1enteev7	576	2	non	non	JJ
cord-350836-1enteev7	576	3	-	-	JJ
cord-350836-1enteev7	576	4	structural	structural	JJ
cord-350836-1enteev7	576	5	protein	protein	NN
cord-350836-1enteev7	576	6	1	1	CD
cord-350836-1enteev7	576	7	antagonizes	antagonize	VBZ
cord-350836-1enteev7	576	8	innate	innate	JJ
cord-350836-1enteev7	576	9	immune	immune	JJ
cord-350836-1enteev7	576	10	response	response	NN
cord-350836-1enteev7	576	11	by	by	IN
cord-350836-1enteev7	576	12	interacting	interact	VBG
cord-350836-1enteev7	576	13	with	with	IN
cord-350836-1enteev7	576	14	retinoic	retinoic	JJ
cord-350836-1enteev7	576	15	acid	acid	NN
cord-350836-1enteev7	576	16	inducible	inducible	JJ
cord-350836-1enteev7	576	17	gene	gene	NN
cord-350836-1enteev7	577	1	I	-PRON-	PRP
cord-350836-1enteev7	577	2	Paramyxovirus	Paramyxovirus	NNP
cord-350836-1enteev7	577	3	V	V	NNP
cord-350836-1enteev7	577	4	proteins	protein	NNS
cord-350836-1enteev7	577	5	disrupt	disrupt	VBP
cord-350836-1enteev7	577	6	the	the	DT
cord-350836-1enteev7	577	7	fold	fold	NN
cord-350836-1enteev7	577	8	of	of	IN
cord-350836-1enteev7	577	9	the	the	DT
cord-350836-1enteev7	577	10	RNA	RNA	NNP
cord-350836-1enteev7	577	11	sensor	sensor	NN
cord-350836-1enteev7	577	12	MDA5	MDA5	NNP
cord-350836-1enteev7	577	13	to	to	TO
cord-350836-1enteev7	577	14	inhibit	inhibit	VB
cord-350836-1enteev7	577	15	antiviral	antiviral	JJ
cord-350836-1enteev7	577	16	signaling	signal	VBG
cord-350836-1enteev7	577	17	Paramyxovirus	Paramyxovirus	NNP
cord-350836-1enteev7	577	18	V	V	NNP
cord-350836-1enteev7	577	19	proteins	protein	NNS
cord-350836-1enteev7	577	20	interact	interact	VBP
cord-350836-1enteev7	577	21	with	with	IN
cord-350836-1enteev7	577	22	the	the	DT
cord-350836-1enteev7	577	23	RIG	rig	NN
cord-350836-1enteev7	578	1	-I	-I	NNP
cord-350836-1enteev7	578	2	/	/	SYM
cord-350836-1enteev7	578	3	TRIM25	TRIM25	NNP
cord-350836-1enteev7	578	4	regulatory	regulatory	JJ
cord-350836-1enteev7	578	5	complex	complex	NN
cord-350836-1enteev7	578	6	and	and	CC
cord-350836-1enteev7	578	7	inhibit	inhibit	NN
cord-350836-1enteev7	579	1	RIG	rig	NN
cord-350836-1enteev7	580	1	-I	-i	DT
cord-350836-1enteev7	580	2	signaling	signal	VBG
cord-350836-1enteev7	580	3	Herpes	Herpes	NNP
cord-350836-1enteev7	580	4	simplex	simplex	NN
cord-350836-1enteev7	580	5	virus	virus	NN
cord-350836-1enteev7	581	1	1	1	CD
cord-350836-1enteev7	581	2	tegument	tegument	NN
cord-350836-1enteev7	581	3	protein	protein	NN
cord-350836-1enteev7	581	4	US11	US11	NNP
cord-350836-1enteev7	581	5	downmodulates	downmodulate	VBZ
cord-350836-1enteev7	581	6	the	the	DT
cord-350836-1enteev7	581	7	RLR	RLR	NNP
cord-350836-1enteev7	581	8	signaling	signal	VBG
cord-350836-1enteev7	581	9	pathway	pathway	NN
cord-350836-1enteev7	581	10	via	via	IN
cord-350836-1enteev7	581	11	direct	direct	JJ
cord-350836-1enteev7	581	12	interaction	interaction	NN
cord-350836-1enteev7	581	13	with	with	IN
cord-350836-1enteev7	581	14	RIG	rig	NN
cord-350836-1enteev7	581	15	-	-	:
cord-350836-1enteev7	581	16	I	-PRON-	PRP
cord-350836-1enteev7	581	17	and	and	CC
cord-350836-1enteev7	581	18	MDA-5	MDA-5	NNP
cord-350836-1enteev7	581	19	Host	Host	NNP
cord-350836-1enteev7	581	20	and	and	CC
cord-350836-1enteev7	581	21	viral	viral	JJ
cord-350836-1enteev7	581	22	modulation	modulation	NN
cord-350836-1enteev7	581	23	of	of	IN
cord-350836-1enteev7	581	24	RIG	rig	NN
cord-350836-1enteev7	581	25	-	-	HYPH
cord-350836-1enteev7	581	26	I	i	NN
cord-350836-1enteev7	581	27	-	-	HYPH
cord-350836-1enteev7	581	28	mediated	mediate	VBN
cord-350836-1enteev7	581	29	antiviral	antiviral	JJ
cord-350836-1enteev7	581	30	immunity	immunity	NN
cord-350836-1enteev7	581	31	.	.	.
cord-350836-1enteev7	582	1	Front	Front	NNP
cord-350836-1enteev7	582	2	Immunol	Immunol	NNP
cord-350836-1enteev7	582	3	USP3	USP3	NNP
cord-350836-1enteev7	582	4	inhibits	inhibit	VBZ
cord-350836-1enteev7	582	5	type	type	NN
cord-350836-1enteev7	583	1	I	-PRON-	PRP
cord-350836-1enteev7	583	2	interferon	interferon	VBP
cord-350836-1enteev7	583	3	signaling	signal	VBG
cord-350836-1enteev7	583	4	by	by	IN
cord-350836-1enteev7	583	5	deubiquitinating	deubiquitinate	VBG
cord-350836-1enteev7	583	6	RIG	rig	NN
cord-350836-1enteev7	583	7	-	-	HYPH
cord-350836-1enteev7	583	8	I	I	NNP
cord-350836-1enteev7	583	9	-	-	HYPH
cord-350836-1enteev7	583	10	like	like	JJ
cord-350836-1enteev7	583	11	receptors	receptor	NNS
cord-350836-1enteev7	584	1	USP14	USP14	NNP
cord-350836-1enteev7	584	2	promotes	promote	VBZ
cord-350836-1enteev7	584	3	K63-linked	K63-linked	NNP
cord-350836-1enteev7	584	4	RIG-	RIG-	NNP
cord-350836-1enteev7	585	1	I	-PRON-	PRP
cord-350836-1enteev7	585	2	deubiquitination	deubiquitination	NN
cord-350836-1enteev7	585	3	and	and	CC
cord-350836-1enteev7	585	4	suppresses	suppress	VBZ
cord-350836-1enteev7	585	5	antiviral	antiviral	JJ
cord-350836-1enteev7	585	6	immune	immune	JJ
cord-350836-1enteev7	585	7	responses	response	NNS
cord-350836-1enteev7	585	8	Mechanism	Mechanism	NNP
cord-350836-1enteev7	585	9	of	of	IN
cord-350836-1enteev7	585	10	inhibiting	inhibit	VBG
cord-350836-1enteev7	585	11	type	type	NN
cord-350836-1enteev7	585	12	I	-PRON-	PRP
cord-350836-1enteev7	585	13	interferon	interferon	VBD
cord-350836-1enteev7	585	14	induction	induction	NN
cord-350836-1enteev7	585	15	by	by	IN
cord-350836-1enteev7	585	16	hepatitis	hepatitis	NNP
cord-350836-1enteev7	585	17	B	B	NNP
cord-350836-1enteev7	585	18	virus	virus	NN
cord-350836-1enteev7	585	19	X	x	NN
cord-350836-1enteev7	585	20	protein	protein	NN
cord-350836-1enteev7	585	21	Porcine	Porcine	NNP
cord-350836-1enteev7	585	22	deltacoronavirus	deltacoronavirus	NN
cord-350836-1enteev7	585	23	nucleocapsid	nucleocapsid	NN
cord-350836-1enteev7	585	24	protein	protein	NN
cord-350836-1enteev7	585	25	suppressed	suppress	VBD
cord-350836-1enteev7	585	26	IFN	IFN	NNP
cord-350836-1enteev7	585	27	-	-	HYPH
cord-350836-1enteev7	585	28	β	β	NN
cord-350836-1enteev7	585	29	production	production	NN
cord-350836-1enteev7	585	30	by	by	IN
cord-350836-1enteev7	585	31	interfering	interfere	VBG
cord-350836-1enteev7	585	32	porcine	porcine	JJ
cord-350836-1enteev7	585	33	RIG	rig	NN
cord-350836-1enteev7	585	34	-	-	:
cord-350836-1enteev7	585	35	I	-PRON-	PRP
cord-350836-1enteev7	585	36	dsRNA	dsrna	RB
cord-350836-1enteev7	585	37	-	-	HYPH
cord-350836-1enteev7	585	38	binding	bind	VBG
cord-350836-1enteev7	585	39	and	and	CC
cord-350836-1enteev7	585	40	K63-linked	k63-linked	JJ
cord-350836-1enteev7	585	41	polyubiquitination	polyubiquitination	NN
cord-350836-1enteev7	586	1	Ubiquitin	Ubiquitin	NNP
cord-350836-1enteev7	586	2	-	-	HYPH
cord-350836-1enteev7	586	3	like	like	JJ
cord-350836-1enteev7	586	4	modifier	modifier	NN
cord-350836-1enteev7	586	5	FAT10	FAT10	NNP
cord-350836-1enteev7	586	6	attenuates	attenuate	VBZ
cord-350836-1enteev7	586	7	RIG	rig	NN
cord-350836-1enteev7	586	8	-	-	:
cord-350836-1enteev7	586	9	I	-PRON-	PRP
cord-350836-1enteev7	586	10	mediated	mediate	VBD
cord-350836-1enteev7	586	11	antiviral	antiviral	JJ
cord-350836-1enteev7	586	12	signaling	signal	VBG
cord-350836-1enteev7	586	13	by	by	IN
cord-350836-1enteev7	586	14	segregating	segregate	VBG
cord-350836-1enteev7	586	15	activated	activate	VBN
cord-350836-1enteev7	586	16	RIG	rig	NN
cord-350836-1enteev7	586	17	-	-	:
cord-350836-1enteev7	586	18	I	-PRON-	PRP
cord-350836-1enteev7	586	19	from	from	IN
cord-350836-1enteev7	586	20	its	-PRON-	PRP$
cord-350836-1enteev7	586	21	signaling	signal	VBG
cord-350836-1enteev7	586	22	platform	platform	NN
cord-350836-1enteev7	587	1	Robust	robust	JJ
cord-350836-1enteev7	587	2	Lys63-linked	lys63-linke	VBN
cord-350836-1enteev7	587	3	ubiquitination	ubiquitination	NN
cord-350836-1enteev7	587	4	of	of	IN
cord-350836-1enteev7	587	5	RIG	rig	NN
cord-350836-1enteev7	588	1	-I	-i	WP
cord-350836-1enteev7	588	2	promotes	promote	VBZ
cord-350836-1enteev7	588	3	cytokine	cytokine	JJ
cord-350836-1enteev7	588	4	eruption	eruption	NN
cord-350836-1enteev7	588	5	in	in	IN
cord-350836-1enteev7	588	6	early	early	JJ
cord-350836-1enteev7	588	7	influenza	influenza	NN
cord-350836-1enteev7	588	8	B	b	NN
cord-350836-1enteev7	588	9	virus	virus	NN
cord-350836-1enteev7	588	10	infection	infection	NN
cord-350836-1enteev7	588	11	Antiviral	antiviral	JJ
cord-350836-1enteev7	588	12	activity	activity	NN
cord-350836-1enteev7	588	13	of	of	IN
cord-350836-1enteev7	588	14	human	human	JJ
cord-350836-1enteev7	588	15	OASL	OASL	NNP
cord-350836-1enteev7	588	16	protein	protein	NN
cord-350836-1enteev7	588	17	is	be	VBZ
cord-350836-1enteev7	588	18	mediated	mediate	VBN
cord-350836-1enteev7	588	19	by	by	IN
cord-350836-1enteev7	588	20	enhancing	enhance	VBG
cord-350836-1enteev7	588	21	signaling	signal	VBG
cord-350836-1enteev7	588	22	of	of	IN
cord-350836-1enteev7	588	23	the	the	DT
cord-350836-1enteev7	588	24	RIG	rig	NN
cord-350836-1enteev7	588	25	-	-	:
cord-350836-1enteev7	588	26	I	I	NNP
cord-350836-1enteev7	588	27	RNA	RNA	NNP
cord-350836-1enteev7	588	28	sensor	sensor	NN
cord-350836-1enteev7	588	29	Negative	negative	JJ
cord-350836-1enteev7	588	30	regulation	regulation	NN
cord-350836-1enteev7	588	31	of	of	IN
cord-350836-1enteev7	588	32	the	the	DT
cord-350836-1enteev7	588	33	RIG	rig	NN
cord-350836-1enteev7	588	34	-	-	:
cord-350836-1enteev7	588	35	I	i	NN
cord-350836-1enteev7	588	36	signaling	signal	VBG
cord-350836-1enteev7	588	37	by	by	IN
cord-350836-1enteev7	588	38	the	the	DT
cord-350836-1enteev7	588	39	ubiquitin	ubiquitin	NN
cord-350836-1enteev7	588	40	ligase	ligase	NN
cord-350836-1enteev7	589	1	RNF125	RNF125	NNP
cord-350836-1enteev7	589	2	Induction	Induction	NNP
cord-350836-1enteev7	589	3	of	of	IN
cord-350836-1enteev7	589	4	Siglec	Siglec	NNP
cord-350836-1enteev7	589	5	-	-	HYPH
cord-350836-1enteev7	589	6	G	G	NNP
cord-350836-1enteev7	589	7	by	by	IN
cord-350836-1enteev7	589	8	RNA	RNA	NNP
cord-350836-1enteev7	589	9	viruses	virus	NNS
cord-350836-1enteev7	589	10	inhibits	inhibit	VBZ
cord-350836-1enteev7	589	11	the	the	DT
cord-350836-1enteev7	589	12	innate	innate	JJ
cord-350836-1enteev7	589	13	immune	immune	JJ
cord-350836-1enteev7	589	14	response	response	NN
cord-350836-1enteev7	589	15	by	by	IN
cord-350836-1enteev7	589	16	promoting	promote	VBG
cord-350836-1enteev7	589	17	RIG	rig	NN
cord-350836-1enteev7	589	18	-	-	:
cord-350836-1enteev7	589	19	I	-PRON-	PRP
cord-350836-1enteev7	589	20	degradation	degradation	NN
cord-350836-1enteev7	589	21	Cytoplasmic	Cytoplasmic	NNP
cord-350836-1enteev7	589	22	STAT4	stat4	NN
cord-350836-1enteev7	589	23	promotes	promote	VBZ
cord-350836-1enteev7	589	24	antiviral	antiviral	JJ
cord-350836-1enteev7	589	25	type	type	NN
cord-350836-1enteev7	590	1	I	-PRON-	PRP
cord-350836-1enteev7	590	2	IFN	IFN	NNP
cord-350836-1enteev7	590	3	production	production	NN
cord-350836-1enteev7	590	4	by	by	IN
cord-350836-1enteev7	590	5	blocking	block	VBG
cord-350836-1enteev7	590	6	CHIPmediated	chipmediated	JJ
cord-350836-1enteev7	590	7	degradation	degradation	NN
cord-350836-1enteev7	590	8	of	of	IN
cord-350836-1enteev7	590	9	RIG-	RIG-	NNP
cord-350836-1enteev7	591	1	I	-PRON-	PRP
cord-350836-1enteev7	591	2	kai	kai	NNP
cord-350836-1enteev7	591	3	LRRC25	LRRC25	NNP
cord-350836-1enteev7	591	4	inhibits	inhibit	VBZ
cord-350836-1enteev7	591	5	type	type	NN
cord-350836-1enteev7	592	1	I	-PRON-	PRP
cord-350836-1enteev7	592	2	IFN	IFN	NNP
cord-350836-1enteev7	592	3	signaling	signal	VBG
cord-350836-1enteev7	592	4	by	by	IN
cord-350836-1enteev7	592	5	targeting	target	VBG
cord-350836-1enteev7	592	6	ISG15-associated	ISG15-associated	NNP
cord-350836-1enteev7	592	7	RIG	rig	NN
cord-350836-1enteev7	592	8	-	-	:
cord-350836-1enteev7	592	9	I	-PRON-	PRP
cord-350836-1enteev7	592	10	for	for	IN
cord-350836-1enteev7	592	11	autophagic	autophagic	JJ
cord-350836-1enteev7	592	12	degradation	degradation	NN
cord-350836-1enteev7	593	1	LRRC59	LRRC59	NNP
cord-350836-1enteev7	593	2	modulates	modulate	VBZ
cord-350836-1enteev7	593	3	type	type	NN
cord-350836-1enteev7	594	1	I	-PRON-	PRP
cord-350836-1enteev7	594	2	interferon	interferon	RB
cord-350836-1enteev7	594	3	signaling	signal	VBG
cord-350836-1enteev7	594	4	by	by	IN
cord-350836-1enteev7	594	5	restraining	restrain	VBG
cord-350836-1enteev7	594	6	the	the	DT
cord-350836-1enteev7	594	7	SQSTM1	SQSTM1	NNPS
cord-350836-1enteev7	594	8	/	/	SYM
cord-350836-1enteev7	594	9	p62-mediated	p62-mediate	VBN
cord-350836-1enteev7	594	10	autophagic	autophagic	JJ
cord-350836-1enteev7	594	11	degradation	degradation	NN
cord-350836-1enteev7	594	12	of	of	IN
cord-350836-1enteev7	594	13	pattern	pattern	NN
cord-350836-1enteev7	594	14	recognition	recognition	NN
cord-350836-1enteev7	594	15	receptor	receptor	NN
cord-350836-1enteev7	594	16	DDX58	DDX58	NNP
cord-350836-1enteev7	594	17	/	/	SYM
cord-350836-1enteev7	594	18	RIG	rig	NN
cord-350836-1enteev7	595	1	-I	-I	NFP
cord-350836-1enteev7	595	2	Mitophagy	Mitophagy	NNP
cord-350836-1enteev7	595	3	enhances	enhance	VBZ
cord-350836-1enteev7	595	4	oncolytic	oncolytic	JJ
cord-350836-1enteev7	595	5	measles	measles	NN
cord-350836-1enteev7	595	6	virus	virus	NN
cord-350836-1enteev7	595	7	replication	replication	NN
cord-350836-1enteev7	595	8	by	by	IN
cord-350836-1enteev7	595	9	mitigating	mitigate	VBG
cord-350836-1enteev7	595	10	DDX58	DDX58	NNP
cord-350836-1enteev7	595	11	/	/	SYM
cord-350836-1enteev7	595	12	RIG	rig	NN
cord-350836-1enteev7	595	13	-	-	:
cord-350836-1enteev7	595	14	Ilike	Ilike	NNP
cord-350836-1enteev7	595	15	receptor	receptor	NN
cord-350836-1enteev7	595	16	signaling	signal	VBG
cord-350836-1enteev7	595	17	RIG	rig	NN
cord-350836-1enteev7	595	18	-	-	:
cord-350836-1enteev7	595	19	I	-PRON-	PRP
cord-350836-1enteev7	595	20	is	be	VBZ
cord-350836-1enteev7	595	21	cleaved	cleave	VBN
cord-350836-1enteev7	595	22	during	during	IN
cord-350836-1enteev7	595	23	picornavirus	picornavirus	NNP
cord-350836-1enteev7	595	24	infection	infection	NN
cord-350836-1enteev7	595	25	Foot	Foot	NNP
cord-350836-1enteev7	595	26	-	-	HYPH
cord-350836-1enteev7	595	27	andmouth	andmouth	NNP
cord-350836-1enteev7	595	28	disease	disease	NNP
cord-350836-1enteev7	595	29	virus	virus	NN
cord-350836-1enteev7	595	30	viroporin	viroporin	NNP
cord-350836-1enteev7	595	31	2B	2B	NNP
cord-350836-1enteev7	595	32	antagonizes	antagonize	VBZ
cord-350836-1enteev7	595	33	RIG	rig	NN
cord-350836-1enteev7	595	34	-	-	HYPH
cord-350836-1enteev7	595	35	I	i	NN
cord-350836-1enteev7	595	36	-	-	HYPH
cord-350836-1enteev7	595	37	mediated	mediate	VBN
cord-350836-1enteev7	595	38	antiviral	antiviral	JJ
cord-350836-1enteev7	595	39	effects	effect	NNS
cord-350836-1enteev7	595	40	by	by	IN
cord-350836-1enteev7	595	41	inhibition	inhibition	NN
cord-350836-1enteev7	595	42	of	of	IN
cord-350836-1enteev7	595	43	its	-PRON-	PRP$
cord-350836-1enteev7	595	44	protein	protein	NN
cord-350836-1enteev7	595	45	expression	expression	NN
cord-350836-1enteev7	595	46	MDA-5	MDA-5	NNP
cord-350836-1enteev7	595	47	is	be	VBZ
cord-350836-1enteev7	595	48	cleaved	cleave	VBN
cord-350836-1enteev7	595	49	in	in	IN
cord-350836-1enteev7	595	50	poliovirus	poliovirus	NN
cord-350836-1enteev7	595	51	-	-	HYPH
cord-350836-1enteev7	595	52	infected	infect	VBN
cord-350836-1enteev7	595	53	cells	cell	NNS
cord-350836-1enteev7	595	54	RNF122	RNF122	NNP
cord-350836-1enteev7	595	55	suppresses	suppress	VBZ
cord-350836-1enteev7	595	56	antiviral	antiviral	JJ
cord-350836-1enteev7	595	57	type	type	NN
cord-350836-1enteev7	596	1	I	-PRON-	PRP
cord-350836-1enteev7	596	2	interferon	interferon	VBD
cord-350836-1enteev7	596	3	production	production	NN
cord-350836-1enteev7	596	4	by	by	IN
cord-350836-1enteev7	596	5	targeting	target	VBG
cord-350836-1enteev7	596	6	RIG	rig	NN
cord-350836-1enteev7	597	1	-I	-I	JJS
cord-350836-1enteev7	597	2	CARDs	card	NNS
cord-350836-1enteev7	597	3	to	to	TO
cord-350836-1enteev7	597	4	mediate	mediate	VB
cord-350836-1enteev7	597	5	RIG	rig	NN
cord-350836-1enteev7	597	6	-	-	:
cord-350836-1enteev7	597	7	I	i	NN
cord-350836-1enteev7	598	1	degradation	degradation	NN
cord-350836-1enteev7	598	2	MLL5	MLL5	NNP
cord-350836-1enteev7	598	3	suppresses	suppress	VBZ
cord-350836-1enteev7	598	4	antiviral	antiviral	JJ
cord-350836-1enteev7	598	5	innate	innate	JJ
cord-350836-1enteev7	598	6	immune	immune	JJ
cord-350836-1enteev7	598	7	response	response	NN
cord-350836-1enteev7	598	8	by	by	IN
cord-350836-1enteev7	598	9	facilitating	facilitate	VBG
cord-350836-1enteev7	598	10	STUB1-mediated	STUB1-mediated	NNP
cord-350836-1enteev7	598	11	RIG	rig	NN
cord-350836-1enteev7	598	12	-	-	:
cord-350836-1enteev7	598	13	I	-PRON-	PRP
cord-350836-1enteev7	598	14	degradation	degradation	NN
cord-350836-1enteev7	599	1	The	the	DT
cord-350836-1enteev7	599	2	levels	level	NNS
cord-350836-1enteev7	599	3	of	of	IN
cord-350836-1enteev7	599	4	retinoic	retinoic	JJ
cord-350836-1enteev7	599	5	acid	acid	NN
cord-350836-1enteev7	599	6	-	-	HYPH
cord-350836-1enteev7	599	7	inducible	inducible	JJ
cord-350836-1enteev7	599	8	gene	gene	NN
cord-350836-1enteev7	599	9	I	-PRON-	PRP
cord-350836-1enteev7	599	10	are	be	VBP
cord-350836-1enteev7	599	11	regulated	regulate	VBN
cord-350836-1enteev7	599	12	by	by	IN
cord-350836-1enteev7	599	13	heat	heat	NN
cord-350836-1enteev7	599	14	shock	shock	NN
cord-350836-1enteev7	599	15	protein	protein	NN
cord-350836-1enteev7	599	16	90-alpha	90-alpha	CD
cord-350836-1enteev7	599	17	PACT	PACT	NNP
cord-350836-1enteev7	599	18	,	,	,
cord-350836-1enteev7	599	19	a	a	DT
cord-350836-1enteev7	599	20	double	double	RB
cord-350836-1enteev7	599	21	-	-	HYPH
cord-350836-1enteev7	599	22	stranded	strand	VBN
cord-350836-1enteev7	599	23	RNA	RNA	NNP
cord-350836-1enteev7	599	24	binding	bind	VBG
cord-350836-1enteev7	599	25	protein	protein	NN
cord-350836-1enteev7	599	26	acts	act	VBZ
cord-350836-1enteev7	599	27	as	as	IN
cord-350836-1enteev7	599	28	a	a	DT
cord-350836-1enteev7	599	29	positive	positive	JJ
cord-350836-1enteev7	599	30	regulator	regulator	NN
cord-350836-1enteev7	599	31	for	for	IN
cord-350836-1enteev7	599	32	type	type	NN
cord-350836-1enteev7	600	1	I	-PRON-	PRP
cord-350836-1enteev7	600	2	interferon	interferon	NN
cord-350836-1enteev7	600	3	gene	gene	NN
cord-350836-1enteev7	600	4	induced	induce	VBN
cord-350836-1enteev7	600	5	by	by	IN
cord-350836-1enteev7	600	6	Newcastle	Newcastle	NNP
cord-350836-1enteev7	600	7	disease	disease	NN
cord-350836-1enteev7	600	8	virus	virus	NN
cord-350836-1enteev7	601	1	The	the	DT
cord-350836-1enteev7	601	2	double	double	RB
cord-350836-1enteev7	601	3	-	-	HYPH
cord-350836-1enteev7	601	4	stranded	strand	VBN
cord-350836-1enteev7	601	5	RNA	rna	NN
cord-350836-1enteev7	601	6	-	-	HYPH
cord-350836-1enteev7	601	7	binding	bind	VBG
cord-350836-1enteev7	601	8	protein	protein	NN
cord-350836-1enteev7	601	9	PACT	PACT	NNP
cord-350836-1enteev7	601	10	functions	function	NNS
cord-350836-1enteev7	601	11	as	as	IN
cord-350836-1enteev7	601	12	a	a	DT
cord-350836-1enteev7	601	13	cellular	cellular	JJ
cord-350836-1enteev7	601	14	activator	activator	NN
cord-350836-1enteev7	601	15	of	of	IN
cord-350836-1enteev7	601	16	RIG	rig	NN
cord-350836-1enteev7	601	17	-	-	:
cord-350836-1enteev7	601	18	I	-PRON-	PRP
cord-350836-1enteev7	601	19	to	to	TO
cord-350836-1enteev7	601	20	facilitate	facilitate	VB
cord-350836-1enteev7	601	21	innate	innate	JJ
cord-350836-1enteev7	601	22	antiviral	antiviral	JJ
cord-350836-1enteev7	601	23	response	response	NN
cord-350836-1enteev7	601	24	TBK1-associated	TBK1-associated	NNP
cord-350836-1enteev7	601	25	protein	protein	NN
cord-350836-1enteev7	601	26	in	in	IN
cord-350836-1enteev7	601	27	endolysosomes	endolysosomes	NNP
cord-350836-1enteev7	602	1	(	(	-LRB-
cord-350836-1enteev7	602	2	TAPE)/CC2D1A	tape)/cc2d1a	NN
cord-350836-1enteev7	602	3	is	be	VBZ
cord-350836-1enteev7	602	4	a	a	DT
cord-350836-1enteev7	602	5	key	key	JJ
cord-350836-1enteev7	602	6	regulator	regulator	NN
cord-350836-1enteev7	602	7	linking	link	VBG
cord-350836-1enteev7	602	8	RIG	rig	NN
cord-350836-1enteev7	602	9	-	-	HYPH
cord-350836-1enteev7	602	10	I	i	NN
cord-350836-1enteev7	602	11	-	-	HYPH
cord-350836-1enteev7	602	12	like	like	JJ
cord-350836-1enteev7	602	13	receptors	receptor	NNS
cord-350836-1enteev7	602	14	to	to	IN
cord-350836-1enteev7	602	15	antiviral	antiviral	JJ
cord-350836-1enteev7	602	16	immunity	immunity	NN
cord-350836-1enteev7	602	17	Cell	cell	NN
cord-350836-1enteev7	602	18	type	type	NN
cord-350836-1enteev7	602	19	-	-	HYPH
cord-350836-1enteev7	602	20	specific	specific	JJ
cord-350836-1enteev7	602	21	subcellular	subcellular	JJ
cord-350836-1enteev7	602	22	localization	localization	NN
cord-350836-1enteev7	602	23	of	of	IN
cord-350836-1enteev7	602	24	phospho	phospho	NNP
cord-350836-1enteev7	602	25	-	-	:
cord-350836-1enteev7	602	26	TBK1	TBK1	NNP
cord-350836-1enteev7	602	27	in	in	IN
cord-350836-1enteev7	602	28	response	response	NN
cord-350836-1enteev7	602	29	to	to	IN
cord-350836-1enteev7	602	30	cytoplasmic	cytoplasmic	JJ
cord-350836-1enteev7	602	31	viral	viral	JJ
cord-350836-1enteev7	602	32	DNA	DNA	NNP
cord-350836-1enteev7	602	33	Zika	Zika	NNP
cord-350836-1enteev7	602	34	virus	virus	NN
cord-350836-1enteev7	603	1	disrupts	disrupt	VBZ
cord-350836-1enteev7	603	2	phospho	phospho	NNP
cord-350836-1enteev7	603	3	-	-	HYPH
cord-350836-1enteev7	603	4	TBK1	TBK1	NNP
cord-350836-1enteev7	603	5	localization	localization	NN
cord-350836-1enteev7	603	6	and	and	CC
cord-350836-1enteev7	603	7	mitosis	mitosis	NN
cord-350836-1enteev7	603	8	in	in	IN
cord-350836-1enteev7	603	9	human	human	JJ
cord-350836-1enteev7	603	10	neuroepithelial	neuroepithelial	JJ
cord-350836-1enteev7	603	11	stem	stem	NN
cord-350836-1enteev7	603	12	cells	cell	NNS
cord-350836-1enteev7	603	13	and	and	CC
cord-350836-1enteev7	603	14	radial	radial	JJ
cord-350836-1enteev7	603	15	glia	glia	NNP
cord-350836-1enteev7	603	16	Zebrafish	zebrafish	NN
cord-350836-1enteev7	603	17	MVP	MVP	NNP
cord-350836-1enteev7	603	18	recruits	recruit	VBZ
cord-350836-1enteev7	603	19	and	and	CC
cord-350836-1enteev7	603	20	degrades	degrade	VBZ
cord-350836-1enteev7	603	21	TBK1	TBK1	NNP
cord-350836-1enteev7	603	22	to	to	TO
cord-350836-1enteev7	603	23	suppress	suppress	VB
cord-350836-1enteev7	603	24	IFN	IFN	NNP
cord-350836-1enteev7	603	25	production	production	NN
cord-350836-1enteev7	604	1	The	the	DT
cord-350836-1enteev7	604	2	role	role	NN
cord-350836-1enteev7	604	3	of	of	IN
cord-350836-1enteev7	604	4	optineurin	optineurin	NNP
cord-350836-1enteev7	604	5	in	in	IN
cord-350836-1enteev7	604	6	antiviral	antiviral	JJ
cord-350836-1enteev7	604	7	type	type	NN
cord-350836-1enteev7	605	1	I	-PRON-	PRP
cord-350836-1enteev7	605	2	interferon	interferon	VBD
cord-350836-1enteev7	605	3	production	production	NN
cord-350836-1enteev7	606	1	Structural	structural	JJ
cord-350836-1enteev7	606	2	and	and	CC
cord-350836-1enteev7	606	3	functional	functional	JJ
cord-350836-1enteev7	606	4	analysis	analysis	NN
cord-350836-1enteev7	606	5	reveals	reveal	VBZ
cord-350836-1enteev7	606	6	that	that	IN
cord-350836-1enteev7	606	7	human	human	JJ
cord-350836-1enteev7	606	8	OASL	OASL	NNP
cord-350836-1enteev7	606	9	binds	bind	VBZ
cord-350836-1enteev7	606	10	dsRNA	dsrna	NN
cord-350836-1enteev7	606	11	to	to	TO
cord-350836-1enteev7	606	12	enhance	enhance	VB
cord-350836-1enteev7	606	13	RIG	rig	NN
cord-350836-1enteev7	607	1	-I	-i	DT
cord-350836-1enteev7	607	2	signaling	signal	VBG
cord-350836-1enteev7	607	3	Reversal	reversal	NN
cord-350836-1enteev7	607	4	of	of	IN
cord-350836-1enteev7	607	5	the	the	DT
cord-350836-1enteev7	607	6	interferon	interferon	NN
cord-350836-1enteev7	607	7	-	-	HYPH
cord-350836-1enteev7	607	8	sensitive	sensitive	JJ
cord-350836-1enteev7	607	9	phenotype	phenotype	NN
cord-350836-1enteev7	607	10	of	of	IN
cord-350836-1enteev7	607	11	a	a	DT
cord-350836-1enteev7	607	12	vaccinia	vaccinia	NN
cord-350836-1enteev7	607	13	virus	virus	NN
cord-350836-1enteev7	607	14	lacking	lack	VBG
cord-350836-1enteev7	607	15	E3L	e3l	RB
cord-350836-1enteev7	607	16	by	by	IN
cord-350836-1enteev7	607	17	expression	expression	NN
cord-350836-1enteev7	607	18	of	of	IN
cord-350836-1enteev7	607	19	the	the	DT
cord-350836-1enteev7	607	20	reovirus	reovirus	NNP
cord-350836-1enteev7	607	21	S4	S4	NNP
cord-350836-1enteev7	607	22	gene	gene	NN
cord-350836-1enteev7	607	23	Human	Human	NNP
cord-350836-1enteev7	607	24	TRBP	TRBP	NNP
cord-350836-1enteev7	607	25	and	and	CC
cord-350836-1enteev7	607	26	PACT	PACT	NNP
cord-350836-1enteev7	607	27	directly	directly	RB
cord-350836-1enteev7	607	28	interact	interact	VBP
cord-350836-1enteev7	607	29	with	with	IN
cord-350836-1enteev7	607	30	each	each	DT
cord-350836-1enteev7	607	31	other	other	JJ
cord-350836-1enteev7	607	32	and	and	CC
cord-350836-1enteev7	607	33	associate	associate	JJ
cord-350836-1enteev7	607	34	with	with	IN
cord-350836-1enteev7	607	35	dicer	dicer	NN
cord-350836-1enteev7	607	36	to	to	TO
cord-350836-1enteev7	607	37	facilitate	facilitate	VB
cord-350836-1enteev7	607	38	the	the	DT
cord-350836-1enteev7	607	39	production	production	NN
cord-350836-1enteev7	607	40	of	of	IN
cord-350836-1enteev7	607	41	small	small	JJ
cord-350836-1enteev7	607	42	interfering	interfere	VBG
cord-350836-1enteev7	607	43	RNA	RNA	NNP
cord-350836-1enteev7	607	44	Approaching	approach	VBG
cord-350836-1enteev7	607	45	the	the	DT
cord-350836-1enteev7	607	46	RNA	RNA	NNP
cord-350836-1enteev7	607	47	ligand	ligand	NN
cord-350836-1enteev7	607	48	for	for	IN
cord-350836-1enteev7	607	49	RIG	rig	NN
cord-350836-1enteev7	607	50	-	-	:
cord-350836-1enteev7	607	51	I	-PRON-	PRP
cord-350836-1enteev7	607	52	?	?	.
cord-350836-1enteev7	608	1	Viral	viral	JJ
cord-350836-1enteev7	608	2	inhibitions	inhibition	NNS
cord-350836-1enteev7	608	3	of	of	IN
cord-350836-1enteev7	608	4	PACT	pact	NN
cord-350836-1enteev7	608	5	-	-	HYPH
cord-350836-1enteev7	608	6	induced	induce	VBN
cord-350836-1enteev7	608	7	RIG	rig	NN
cord-350836-1enteev7	609	1	-I	-i	WDT
cord-350836-1enteev7	609	2	activation	activation	NN
cord-350836-1enteev7	609	3	Hemorrhagic	hemorrhagic	JJ
cord-350836-1enteev7	609	4	fever	fever	NN
cord-350836-1enteev7	609	5	-	-	HYPH
cord-350836-1enteev7	609	6	causing	cause	VBG
cord-350836-1enteev7	609	7	arenaviruses	arenavirus	NNS
cord-350836-1enteev7	609	8	:	:	:
cord-350836-1enteev7	609	9	lethal	lethal	JJ
cord-350836-1enteev7	609	10	pathogens	pathogen	NNS
cord-350836-1enteev7	609	11	and	and	CC
cord-350836-1enteev7	609	12	potent	potent	JJ
cord-350836-1enteev7	609	13	immune	immune	JJ
cord-350836-1enteev7	609	14	suppressors	suppressor	NNS
cord-350836-1enteev7	610	1	Porcine	porcine	JJ
cord-350836-1enteev7	610	2	deltacoronavirus	deltacoronavirus	NN
cord-350836-1enteev7	610	3	nucleocapsid	nucleocapsid	NN
cord-350836-1enteev7	610	4	protein	protein	NN
cord-350836-1enteev7	610	5	antagonizes	antagonize	VBZ
cord-350836-1enteev7	610	6	IFN	IFN	NNP
cord-350836-1enteev7	610	7	-	-	HYPH
cord-350836-1enteev7	610	8	β	β	NN
cord-350836-1enteev7	610	9	production	production	NN
cord-350836-1enteev7	610	10	by	by	IN
cord-350836-1enteev7	610	11	impairing	impair	VBG
cord-350836-1enteev7	610	12	dsRNA	dsrna	NN
cord-350836-1enteev7	610	13	and	and	CC
cord-350836-1enteev7	610	14	PACT	pact	NN
cord-350836-1enteev7	610	15	binding	bind	VBG
cord-350836-1enteev7	610	16	to	to	IN
cord-350836-1enteev7	610	17	RIG-	RIG-	NNP
cord-350836-1enteev7	611	1	I	-PRON-	PRP
cord-350836-1enteev7	611	2	RAVER1	raver1	NN
cord-350836-1enteev7	611	3	is	be	VBZ
cord-350836-1enteev7	611	4	a	a	DT
cord-350836-1enteev7	611	5	coactivator	coactivator	NN
cord-350836-1enteev7	611	6	of	of	IN
cord-350836-1enteev7	611	7	MDA5-mediated	MDA5-mediated	NNP
cord-350836-1enteev7	611	8	cellular	cellular	JJ
cord-350836-1enteev7	611	9	antiviral	antiviral	JJ
cord-350836-1enteev7	611	10	response	response	NN
cord-350836-1enteev7	611	11	Human	human	JJ
cord-350836-1enteev7	611	12	hemoglobin	hemoglobin	NN
cord-350836-1enteev7	611	13	subunit	subunit	NN
cord-350836-1enteev7	611	14	beta	beta	NN
cord-350836-1enteev7	611	15	functions	function	NNS
cord-350836-1enteev7	611	16	as	as	IN
cord-350836-1enteev7	611	17	a	a	DT
cord-350836-1enteev7	611	18	pleiotropic	pleiotropic	JJ
cord-350836-1enteev7	611	19	regulator	regulator	NN
cord-350836-1enteev7	611	20	of	of	IN
cord-350836-1enteev7	611	21	the	the	DT
cord-350836-1enteev7	611	22	RIG	rig	NN
cord-350836-1enteev7	611	23	-	-	HYPH
cord-350836-1enteev7	611	24	I	I	NNP
cord-350836-1enteev7	611	25	/	/	SYM
cord-350836-1enteev7	611	26	MDA5-mediated	MDA5-mediated	NNP
cord-350836-1enteev7	611	27	antiviral	antiviral	JJ
cord-350836-1enteev7	611	28	innate	innate	VBP
cord-350836-1enteev7	611	29	immune	immune	JJ
cord-350836-1enteev7	611	30	responses	response	NNS
cord-350836-1enteev7	611	31	PACT	PACT	NNP
cord-350836-1enteev7	611	32	,	,	,
cord-350836-1enteev7	611	33	a	a	DT
cord-350836-1enteev7	611	34	protein	protein	NN
cord-350836-1enteev7	611	35	activator	activator	NN
cord-350836-1enteev7	611	36	of	of	IN
cord-350836-1enteev7	611	37	the	the	DT
cord-350836-1enteev7	611	38	interferoninduced	interferoninduced	JJ
cord-350836-1enteev7	611	39	protein	protein	NN
cord-350836-1enteev7	611	40	kinase	kinase	NN
cord-350836-1enteev7	611	41	,	,	,
cord-350836-1enteev7	611	42	PKR	PKR	NNP
cord-350836-1enteev7	612	1	The	the	DT
cord-350836-1enteev7	612	2	role	role	NN
cord-350836-1enteev7	612	3	of	of	IN
cord-350836-1enteev7	612	4	PACT	pact	NN
cord-350836-1enteev7	612	5	in	in	IN
cord-350836-1enteev7	612	6	mediating	mediate	VBG
cord-350836-1enteev7	612	7	gene	gene	NN
cord-350836-1enteev7	612	8	induction	induction	NN
cord-350836-1enteev7	612	9	,	,	,
cord-350836-1enteev7	612	10	PKR	PKR	NNP
cord-350836-1enteev7	612	11	activation	activation	NN
cord-350836-1enteev7	612	12	,	,	,
cord-350836-1enteev7	612	13	and	and	CC
cord-350836-1enteev7	612	14	apoptosis	apoptosis	NN
cord-350836-1enteev7	612	15	in	in	IN
cord-350836-1enteev7	612	16	response	response	NN
cord-350836-1enteev7	612	17	to	to	IN
cord-350836-1enteev7	612	18	diverse	diverse	JJ
cord-350836-1enteev7	612	19	stimuli	stimulus	NNS
cord-350836-1enteev7	612	20	DHX36	DHX36	NNP
cord-350836-1enteev7	612	21	enhances	enhance	VBZ
cord-350836-1enteev7	612	22	RIG	rig	NN
cord-350836-1enteev7	613	1	-I	-i	DT
cord-350836-1enteev7	613	2	signaling	signal	VBG
cord-350836-1enteev7	613	3	by	by	IN
cord-350836-1enteev7	613	4	facilitating	facilitate	VBG
cord-350836-1enteev7	613	5	PKRmediated	pkrmediated	JJ
cord-350836-1enteev7	613	6	antiviral	antiviral	JJ
cord-350836-1enteev7	613	7	stress	stress	NN
cord-350836-1enteev7	613	8	granule	granule	NN
cord-350836-1enteev7	613	9	formation	formation	NN
cord-350836-1enteev7	613	10	Regulation	regulation	NN
cord-350836-1enteev7	613	11	of	of	IN
cord-350836-1enteev7	613	12	antiviral	antiviral	JJ
cord-350836-1enteev7	613	13	innate	innate	JJ
cord-350836-1enteev7	613	14	immune	immune	JJ
cord-350836-1enteev7	613	15	signaling	signal	VBG
cord-350836-1enteev7	613	16	by	by	IN
cord-350836-1enteev7	613	17	stress	stress	NN
cord-350836-1enteev7	613	18	-	-	HYPH
cord-350836-1enteev7	613	19	induced	induce	VBN
cord-350836-1enteev7	613	20	RNA	RNA	NNP
cord-350836-1enteev7	613	21	granules	granule	NNS
cord-350836-1enteev7	613	22	Critical	critical	JJ
cord-350836-1enteev7	613	23	role	role	NN
cord-350836-1enteev7	613	24	of	of	IN
cord-350836-1enteev7	613	25	an	an	DT
cord-350836-1enteev7	613	26	antiviral	antiviral	JJ
cord-350836-1enteev7	613	27	stress	stress	NN
cord-350836-1enteev7	613	28	granule	granule	NN
cord-350836-1enteev7	613	29	containing	contain	VBG
cord-350836-1enteev7	613	30	RIG	rig	NN
cord-350836-1enteev7	613	31	-	-	:
cord-350836-1enteev7	613	32	I	I	NNP
cord-350836-1enteev7	613	33	and	and	CC
cord-350836-1enteev7	613	34	PKR	PKR	NNP
cord-350836-1enteev7	613	35	in	in	IN
cord-350836-1enteev7	613	36	viral	viral	JJ
cord-350836-1enteev7	613	37	detection	detection	NN
cord-350836-1enteev7	613	38	and	and	CC
cord-350836-1enteev7	613	39	innate	innate	JJ
cord-350836-1enteev7	613	40	immunity	immunity	NN
cord-350836-1enteev7	613	41	Subcellular	Subcellular	NNP
cord-350836-1enteev7	613	42	localizations	localization	NNS
cord-350836-1enteev7	613	43	of	of	IN
cord-350836-1enteev7	613	44	RIG	rig	NN
cord-350836-1enteev7	613	45	-	-	:
cord-350836-1enteev7	613	46	I	i	NN
cord-350836-1enteev7	613	47	,	,	,
cord-350836-1enteev7	613	48	TRIM25	TRIM25	NNP
cord-350836-1enteev7	613	49	,	,	,
cord-350836-1enteev7	613	50	and	and	CC
cord-350836-1enteev7	613	51	MAVS	MAVS	NNP
cord-350836-1enteev7	613	52	complexes	complex	NNS
cord-350836-1enteev7	614	1	PKR	PKR	NNP
cord-350836-1enteev7	614	2	transduces	transduces	NNP
cord-350836-1enteev7	615	1	MDA5-dependent	MDA5-dependent	NNP
cord-350836-1enteev7	615	2	signals	signal	NNS
cord-350836-1enteev7	615	3	for	for	IN
cord-350836-1enteev7	615	4	type	type	NN
cord-350836-1enteev7	616	1	I	-PRON-	PRP
cord-350836-1enteev7	616	2	IFN	IFN	NNP
cord-350836-1enteev7	616	3	induction	induction	NN
cord-350836-1enteev7	617	1	Interferon	interferon	NN
cord-350836-1enteev7	617	2	-	-	HYPH
cord-350836-1enteev7	617	3	inducible	inducible	JJ
cord-350836-1enteev7	617	4	oligoadenylate	oligoadenylate	NN
cord-350836-1enteev7	617	5	synthetase	synthetase	NN
cord-350836-1enteev7	617	6	-	-	HYPH
cord-350836-1enteev7	617	7	like	like	JJ
cord-350836-1enteev7	617	8	protein	protein	NN
cord-350836-1enteev7	617	9	acts	act	NNS
cord-350836-1enteev7	617	10	as	as	IN
cord-350836-1enteev7	617	11	an	an	DT
cord-350836-1enteev7	617	12	antiviral	antiviral	JJ
cord-350836-1enteev7	617	13	effector	effector	NN
cord-350836-1enteev7	617	14	against	against	IN
cord-350836-1enteev7	617	15	classical	classical	JJ
cord-350836-1enteev7	617	16	swine	swine	NN
cord-350836-1enteev7	617	17	fever	fever	NN
cord-350836-1enteev7	617	18	virus	virus	NN
cord-350836-1enteev7	617	19	via	via	IN
cord-350836-1enteev7	617	20	the	the	DT
cord-350836-1enteev7	617	21	MDA5-mediated	MDA5-mediated	NNP
cord-350836-1enteev7	617	22	type	type	NN
cord-350836-1enteev7	618	1	I	-PRON-	PRP
cord-350836-1enteev7	618	2	interferon	interferon	NN
cord-350836-1enteev7	618	3	-	-	HYPH
cord-350836-1enteev7	618	4	signaling	signal	VBG
cord-350836-1enteev7	618	5	pathway	pathway	NN
cord-350836-1enteev7	618	6	Inhibition	inhibition	NN
cord-350836-1enteev7	618	7	of	of	IN
cord-350836-1enteev7	618	8	RIG-	RIG-	NNP
cord-350836-1enteev7	619	1	I	-PRON-	PRP
cord-350836-1enteev7	619	2	and	and	CC
cord-350836-1enteev7	619	3	MDA5-dependent	MDA5-dependent	NNP
cord-350836-1enteev7	619	4	antiviral	antiviral	JJ
cord-350836-1enteev7	619	5	response	response	NN
cord-350836-1enteev7	619	6	by	by	IN
cord-350836-1enteev7	619	7	gC1qR	gC1qR	NNP
cord-350836-1enteev7	619	8	at	at	IN
cord-350836-1enteev7	619	9	mitochondria	mitochondrion	NNS
cord-350836-1enteev7	619	10	TARBP2	TARBP2	NNP
cord-350836-1enteev7	619	11	negatively	negatively	RB
cord-350836-1enteev7	619	12	regulates	regulate	VBZ
cord-350836-1enteev7	619	13	IFN	IFN	NNP
cord-350836-1enteev7	619	14	-	-	HYPH
cord-350836-1enteev7	619	15	β	β	NN
cord-350836-1enteev7	619	16	production	production	NN
cord-350836-1enteev7	619	17	and	and	CC
cord-350836-1enteev7	619	18	innate	innate	JJ
cord-350836-1enteev7	619	19	antiviral	antiviral	JJ
cord-350836-1enteev7	619	20	response	response	NN
cord-350836-1enteev7	619	21	by	by	IN
cord-350836-1enteev7	619	22	targeting	target	VBG
cord-350836-1enteev7	619	23	MAVS	MAVS	NNP
cord-350836-1enteev7	619	24	Lactate	Lactate	NNP
cord-350836-1enteev7	620	1	is	be	VBZ
cord-350836-1enteev7	620	2	a	a	DT
cord-350836-1enteev7	620	3	natural	natural	JJ
cord-350836-1enteev7	620	4	suppressor	suppressor	NN
cord-350836-1enteev7	620	5	of	of	IN
cord-350836-1enteev7	620	6	RLR	RLR	NNP
cord-350836-1enteev7	620	7	signaling	signal	VBG
cord-350836-1enteev7	620	8	by	by	IN
cord-350836-1enteev7	620	9	targeting	target	VBG
cord-350836-1enteev7	620	10	MAVS	MAVS	NNPS
cord-350836-1enteev7	620	11	NLRC5	NLRC5	NNP
cord-350836-1enteev7	620	12	negatively	negatively	RB
cord-350836-1enteev7	620	13	regulates	regulate	VBZ
cord-350836-1enteev7	620	14	the	the	DT
cord-350836-1enteev7	620	15	NF	NF	NNP
cord-350836-1enteev7	620	16	-	-	HYPH
cord-350836-1enteev7	620	17	kappaB	kappaB	NNP
cord-350836-1enteev7	620	18	and	and	CC
cord-350836-1enteev7	620	19	type	type	NN
cord-350836-1enteev7	621	1	I	-PRON-	PRP
cord-350836-1enteev7	621	2	interferon	interferon	RB
cord-350836-1enteev7	621	3	signaling	signal	VBG
cord-350836-1enteev7	621	4	pathways	pathway	NNS
cord-350836-1enteev7	622	1	DHX15	DHX15	NNP
cord-350836-1enteev7	622	2	is	be	VBZ
cord-350836-1enteev7	622	3	a	a	DT
cord-350836-1enteev7	622	4	coreceptor	coreceptor	NN
cord-350836-1enteev7	622	5	for	for	IN
cord-350836-1enteev7	622	6	RLR	RLR	NNP
cord-350836-1enteev7	622	7	signaling	signaling	NN
cord-350836-1enteev7	622	8	that	that	WDT
cord-350836-1enteev7	622	9	promotes	promote	VBZ
cord-350836-1enteev7	622	10	antiviral	antiviral	JJ
cord-350836-1enteev7	622	11	defense	defense	NN
cord-350836-1enteev7	622	12	against	against	IN
cord-350836-1enteev7	622	13	RNA	RNA	NNP
cord-350836-1enteev7	622	14	virus	virus	NN
cord-350836-1enteev7	622	15	infection	infection	NN
cord-350836-1enteev7	622	16	ARFlike	arflike	IN
cord-350836-1enteev7	622	17	protein	protein	NN
cord-350836-1enteev7	622	18	16	16	CD
cord-350836-1enteev7	623	1	(	(	-LRB-
cord-350836-1enteev7	623	2	ARL16	ARL16	NNP
cord-350836-1enteev7	623	3	)	)	-RRB-
cord-350836-1enteev7	623	4	inhibits	inhibit	VBZ
cord-350836-1enteev7	623	5	RIG	rig	NN
cord-350836-1enteev7	623	6	-	-	:
cord-350836-1enteev7	623	7	I	-PRON-	PRP
cord-350836-1enteev7	623	8	by	by	IN
cord-350836-1enteev7	623	9	binding	bind	VBG
cord-350836-1enteev7	623	10	with	with	IN
cord-350836-1enteev7	623	11	its	-PRON-	PRP$
cord-350836-1enteev7	623	12	C	c	NN
cord-350836-1enteev7	623	13	-	-	HYPH
cord-350836-1enteev7	623	14	terminal	terminal	NN
cord-350836-1enteev7	623	15	domain	domain	NN
cord-350836-1enteev7	623	16	in	in	IN
cord-350836-1enteev7	623	17	a	a	DT
cord-350836-1enteev7	623	18	GTP	gtp	NN
cord-350836-1enteev7	623	19	-	-	HYPH
cord-350836-1enteev7	623	20	dependent	dependent	JJ
cord-350836-1enteev7	623	21	manner	manner	NN
cord-350836-1enteev7	624	1	Negative	negative	JJ
cord-350836-1enteev7	624	2	regulation	regulation	NN
cord-350836-1enteev7	624	3	of	of	IN
cord-350836-1enteev7	624	4	melanoma	melanoma	NN
cord-350836-1enteev7	624	5	differentiation	differentiation	NN
cord-350836-1enteev7	624	6	-	-	HYPH
cord-350836-1enteev7	624	7	associated	associate	VBN
cord-350836-1enteev7	624	8	gene	gene	NN
cord-350836-1enteev7	624	9	5	5	CD
cord-350836-1enteev7	624	10	(	(	-LRB-
cord-350836-1enteev7	624	11	MDA5)-dependent	mda5)-dependent	CD
cord-350836-1enteev7	624	12	antiviral	antiviral	JJ
cord-350836-1enteev7	624	13	innate	innate	VBP
cord-350836-1enteev7	624	14	immune	immune	JJ
cord-350836-1enteev7	624	15	responses	response	NNS
cord-350836-1enteev7	624	16	by	by	IN
cord-350836-1enteev7	624	17	Arf	Arf	NNP
cord-350836-1enteev7	624	18	-	-	HYPH
cord-350836-1enteev7	624	19	like	like	JJ
cord-350836-1enteev7	624	20	protein	protein	NN
cord-350836-1enteev7	624	21	5B	5b	NN
cord-350836-1enteev7	624	22	Green	Green	NNP
cord-350836-1enteev7	624	23	tea	tea	NN
cord-350836-1enteev7	624	24	catechin	catechin	NN
cord-350836-1enteev7	624	25	,	,	,
cord-350836-1enteev7	624	26	epigallocatechin	epigallocatechin	NNP
cord-350836-1enteev7	624	27	gallate	gallate	NNP
cord-350836-1enteev7	624	28	,	,	,
cord-350836-1enteev7	624	29	suppresses	suppress	VBZ
cord-350836-1enteev7	624	30	signaling	signal	VBG
cord-350836-1enteev7	624	31	by	by	IN
cord-350836-1enteev7	624	32	the	the	DT
cord-350836-1enteev7	624	33	dsRNA	dsrna	NN
cord-350836-1enteev7	624	34	innate	innate	JJ
cord-350836-1enteev7	624	35	immune	immune	JJ
cord-350836-1enteev7	624	36	receptor	receptor	NN
cord-350836-1enteev7	624	37	RIG	rig	NN
cord-350836-1enteev7	624	38	-	-	:
cord-350836-1enteev7	624	39	I	I	NNP
cord-350836-1enteev7	624	40	Crystal	Crystal	NNP
cord-350836-1enteev7	624	41	structure	structure	NN
cord-350836-1enteev7	624	42	of	of	IN
cord-350836-1enteev7	624	43	a	a	DT
cord-350836-1enteev7	624	44	DEAD	dead	JJ
cord-350836-1enteev7	624	45	box	box	NN
cord-350836-1enteev7	624	46	protein	protein	NN
cord-350836-1enteev7	624	47	from	from	IN
cord-350836-1enteev7	624	48	the	the	DT
cord-350836-1enteev7	624	49	hyperthermophile	hyperthermophile	NN
cord-350836-1enteev7	625	1	Methanococcus	Methanococcus	NNP
cord-350836-1enteev7	625	2	jannaschii	jannaschii	NNP
cord-350836-1enteev7	625	3	Unlocking	unlock	VBG
cord-350836-1enteev7	625	4	the	the	DT
cord-350836-1enteev7	625	5	DEAD	DEAD	NNP
cord-350836-1enteev7	625	6	-	-	HYPH
cord-350836-1enteev7	625	7	box	box	NN
cord-350836-1enteev7	625	8	:	:	:
cord-350836-1enteev7	625	9	a	a	DT
cord-350836-1enteev7	625	10	key	key	NN
cord-350836-1enteev7	625	11	to	to	IN
cord-350836-1enteev7	625	12	cryptococcal	cryptococcal	JJ
cord-350836-1enteev7	625	13	virulence	virulence	NN
cord-350836-1enteev7	625	14	?	?	.
cord-350836-1enteev7	626	1	Sensors	sensor	NNS
cord-350836-1enteev7	626	2	of	of	IN
cord-350836-1enteev7	626	3	infection	infection	NN
cord-350836-1enteev7	626	4	:	:	:
cord-350836-1enteev7	626	5	viral	viral	JJ
cord-350836-1enteev7	626	6	nucleic	nucleic	JJ
cord-350836-1enteev7	626	7	acid	acid	NN
cord-350836-1enteev7	626	8	PRRs	prr	NNS
cord-350836-1enteev7	626	9	in	in	IN
cord-350836-1enteev7	626	10	fish	fish	NN
cord-350836-1enteev7	626	11	Association	Association	NNP
cord-350836-1enteev7	626	12	of	of	IN
cord-350836-1enteev7	626	13	RIG-	RIG-	NNP
cord-350836-1enteev7	627	1	I	-PRON-	PRP
cord-350836-1enteev7	627	2	with	with	IN
cord-350836-1enteev7	627	3	innate	innate	JJ
cord-350836-1enteev7	627	4	immunity	immunity	NN
cord-350836-1enteev7	627	5	of	of	IN
cord-350836-1enteev7	627	6	ducks	duck	NNS
cord-350836-1enteev7	627	7	to	to	TO
cord-350836-1enteev7	627	8	influenza	influenza	VB
cord-350836-1enteev7	627	9	Pathogen	Pathogen	NNP
cord-350836-1enteev7	627	10	recognition	recognition	NN
cord-350836-1enteev7	627	11	receptors	receptor	NNS
cord-350836-1enteev7	627	12	in	in	IN
cord-350836-1enteev7	627	13	channel	channel	NN
cord-350836-1enteev7	627	14	catfish	catfish	NNS
cord-350836-1enteev7	627	15	:	:	:
cord-350836-1enteev7	627	16	II	II	NNP
cord-350836-1enteev7	627	17	.	.	.
cord-350836-1enteev7	628	1	Identification	identification	NN
cord-350836-1enteev7	628	2	,	,	,
cord-350836-1enteev7	628	3	phylogeny	phylogeny	NN
cord-350836-1enteev7	628	4	and	and	CC
cord-350836-1enteev7	628	5	expression	expression	NN
cord-350836-1enteev7	628	6	of	of	IN
cord-350836-1enteev7	628	7	retinoic	retinoic	JJ
cord-350836-1enteev7	628	8	acid	acid	NN
cord-350836-1enteev7	628	9	-	-	HYPH
cord-350836-1enteev7	628	10	inducible	inducible	JJ
cord-350836-1enteev7	628	11	gene	gene	NN
cord-350836-1enteev7	628	12	I	i	NN
cord-350836-1enteev7	628	13	(	(	-LRB-
cord-350836-1enteev7	628	14	RIG	RIG	NNP
cord-350836-1enteev7	628	15	-	-	HYPH
cord-350836-1enteev7	628	16	I)-like	I)-like	NNP
cord-350836-1enteev7	628	17	receptors	receptor	NNS
cord-350836-1enteev7	628	18	(	(	-LRB-
cord-350836-1enteev7	628	19	RLRs	rlr	NNS
cord-350836-1enteev7	628	20	)	)	-RRB-
cord-350836-1enteev7	628	21	Goose	Goose	NNP
cord-350836-1enteev7	628	22	RIG	rig	NN
cord-350836-1enteev7	628	23	-	-	:
cord-350836-1enteev7	628	24	I	-PRON-	PRP
cord-350836-1enteev7	628	25	functions	function	NNS
cord-350836-1enteev7	628	26	in	in	IN
cord-350836-1enteev7	628	27	innate	innate	JJ
cord-350836-1enteev7	628	28	immunity	immunity	NN
cord-350836-1enteev7	628	29	against	against	IN
cord-350836-1enteev7	628	30	Newcastle	Newcastle	NNP
cord-350836-1enteev7	628	31	disease	disease	NN
cord-350836-1enteev7	628	32	virus	virus	NN
cord-350836-1enteev7	628	33	infections	infection	NNS
cord-350836-1enteev7	629	1	Innate	innate	JJ
cord-350836-1enteev7	629	2	immunity	immunity	NN
cord-350836-1enteev7	629	3	of	of	IN
cord-350836-1enteev7	629	4	finfish	finfish	JJ
cord-350836-1enteev7	629	5	:	:	:
cord-350836-1enteev7	629	6	primordial	primordial	JJ
cord-350836-1enteev7	629	7	conservation	conservation	NN
cord-350836-1enteev7	629	8	and	and	CC
cord-350836-1enteev7	629	9	function	function	NN
cord-350836-1enteev7	629	10	of	of	IN
cord-350836-1enteev7	629	11	viral	viral	JJ
cord-350836-1enteev7	629	12	RNA	RNA	NNP
cord-350836-1enteev7	629	13	sensors	sensor	NNS
cord-350836-1enteev7	629	14	in	in	IN
cord-350836-1enteev7	629	15	teleosts	teleost	NNS
cord-350836-1enteev7	630	1	Comparative	comparative	JJ
cord-350836-1enteev7	630	2	study	study	NN
cord-350836-1enteev7	630	3	on	on	IN
cord-350836-1enteev7	630	4	pattern	pattern	NN
cord-350836-1enteev7	630	5	recognition	recognition	NN
cord-350836-1enteev7	630	6	receptors	receptor	NNS
cord-350836-1enteev7	630	7	in	in	IN
cord-350836-1enteev7	630	8	non	non	JJ
cord-350836-1enteev7	630	9	-	-	JJ
cord-350836-1enteev7	630	10	teleost	teleost	JJ
cord-350836-1enteev7	630	11	ray	ray	NN
cord-350836-1enteev7	630	12	-	-	HYPH
cord-350836-1enteev7	630	13	finned	fin	VBN
cord-350836-1enteev7	630	14	fishes	fish	NNS
cord-350836-1enteev7	630	15	and	and	CC
cord-350836-1enteev7	630	16	their	-PRON-	PRP$
cord-350836-1enteev7	630	17	evolutionary	evolutionary	JJ
cord-350836-1enteev7	630	18	significance	significance	NN
cord-350836-1enteev7	630	19	in	in	IN
cord-350836-1enteev7	630	20	primitive	primitive	JJ
cord-350836-1enteev7	630	21	vertebrates	vertebrate	NNS
cord-350836-1enteev7	630	22	Genomic	genomic	JJ
cord-350836-1enteev7	630	23	analysis	analysis	NN
cord-350836-1enteev7	630	24	and	and	CC
cord-350836-1enteev7	630	25	adaptive	adaptive	JJ
cord-350836-1enteev7	630	26	evolution	evolution	NN
cord-350836-1enteev7	630	27	of	of	IN
cord-350836-1enteev7	630	28	the	the	DT
cord-350836-1enteev7	630	29	RIG	rig	NN
cord-350836-1enteev7	630	30	-	-	HYPH
cord-350836-1enteev7	630	31	I	i	NN
cord-350836-1enteev7	630	32	-	-	HYPH
cord-350836-1enteev7	630	33	like	like	JJ
cord-350836-1enteev7	630	34	and	and	CC
cord-350836-1enteev7	630	35	NOD	nod	VB
cord-350836-1enteev7	630	36	-	-	HYPH
cord-350836-1enteev7	630	37	like	like	JJ
cord-350836-1enteev7	630	38	receptors	receptor	NNS
cord-350836-1enteev7	630	39	in	in	IN
cord-350836-1enteev7	630	40	reptiles	reptile	NNS
cord-350836-1enteev7	631	1	NOD	NOD	NNP
cord-350836-1enteev7	631	2	-	-	HYPH
cord-350836-1enteev7	631	3	LRR	LRR	NNP
cord-350836-1enteev7	631	4	PROTEINS	protein	NNS
cord-350836-1enteev7	631	5	:	:	:
cord-350836-1enteev7	631	6	role	role	NN
cord-350836-1enteev7	631	7	in	in	IN
cord-350836-1enteev7	631	8	host	host	NN
cord-350836-1enteev7	631	9	-	-	HYPH
cord-350836-1enteev7	631	10	microbial	microbial	JJ
cord-350836-1enteev7	631	11	interactions	interaction	NNS
cord-350836-1enteev7	631	12	and	and	CC
cord-350836-1enteev7	631	13	inflammatory	inflammatory	JJ
cord-350836-1enteev7	631	14	disease	disease	NN
cord-350836-1enteev7	632	1	A	a	DT
cord-350836-1enteev7	632	2	phylogenetic	phylogenetic	JJ
cord-350836-1enteev7	632	3	and	and	CC
cord-350836-1enteev7	632	4	functional	functional	JJ
cord-350836-1enteev7	632	5	overview	overview	NN
cord-350836-1enteev7	632	6	of	of	IN
cord-350836-1enteev7	632	7	inflammatory	inflammatory	JJ
cord-350836-1enteev7	632	8	caspases	caspase	NNS
cord-350836-1enteev7	632	9	and	and	CC
cord-350836-1enteev7	632	10	caspase-1-related	caspase-1-related	NNP
cord-350836-1enteev7	632	11	CARD	card	NN
cord-350836-1enteev7	632	12	-	-	HYPH
cord-350836-1enteev7	632	13	only	only	RB
cord-350836-1enteev7	632	14	proteins	protein	NNS
cord-350836-1enteev7	632	15	NACHT	NACHT	NNP
cord-350836-1enteev7	632	16	-	-	HYPH
cord-350836-1enteev7	632	17	LRR	LRR	NNP
cord-350836-1enteev7	632	18	proteins	protein	NNS
cord-350836-1enteev7	632	19	(	(	-LRB-
cord-350836-1enteev7	632	20	NLRs	NLRs	NNP
cord-350836-1enteev7	632	21	)	)	-RRB-
cord-350836-1enteev7	632	22	in	in	IN
cord-350836-1enteev7	632	23	bacterial	bacterial	JJ
cord-350836-1enteev7	632	24	infection	infection	NN
cord-350836-1enteev7	632	25	and	and	CC
cord-350836-1enteev7	632	26	immunity	immunity	NN
cord-350836-1enteev7	632	27	Molecular	molecular	JJ
cord-350836-1enteev7	632	28	evolution	evolution	NN
cord-350836-1enteev7	632	29	of	of	IN
cord-350836-1enteev7	632	30	glutamate	glutamate	NN
cord-350836-1enteev7	632	31	receptors	receptor	NNS
cord-350836-1enteev7	632	32	:	:	:
cord-350836-1enteev7	632	33	a	a	DT
cord-350836-1enteev7	632	34	primitive	primitive	JJ
cord-350836-1enteev7	632	35	signaling	signaling	NN
cord-350836-1enteev7	632	36	mechanism	mechanism	NN
cord-350836-1enteev7	632	37	that	that	WDT
cord-350836-1enteev7	632	38	existed	exist	VBD
cord-350836-1enteev7	632	39	before	before	IN
cord-350836-1enteev7	633	1	plants	plant	NNS
cord-350836-1enteev7	633	2	and	and	CC
cord-350836-1enteev7	633	3	animals	animal	NNS
cord-350836-1enteev7	633	4	diverged	diverge	VBD
cord-350836-1enteev7	633	5	The	the	DT
cord-350836-1enteev7	633	6	origin	origin	NN
cord-350836-1enteev7	633	7	of	of	IN
cord-350836-1enteev7	633	8	polynucleotide	polynucleotide	NNP
cord-350836-1enteev7	633	9	phosphorylase	phosphorylase	NNP
cord-350836-1enteev7	633	10	domains	domain	VBZ
cord-350836-1enteev7	633	11	RIG	rig	NN
cord-350836-1enteev7	633	12	-	-	HYPH
cord-350836-1enteev7	633	13	I	i	NN
cord-350836-1enteev7	633	14	-	-	HYPH
cord-350836-1enteev7	633	15	like	like	JJ
cord-350836-1enteev7	633	16	receptors	receptor	NNS
cord-350836-1enteev7	633	17	evolved	evolve	VBN
cord-350836-1enteev7	633	18	adaptively	adaptively	RB
cord-350836-1enteev7	633	19	in	in	IN
cord-350836-1enteev7	633	20	mammals	mammal	NNS
cord-350836-1enteev7	633	21	,	,	,
cord-350836-1enteev7	633	22	with	with	IN
cord-350836-1enteev7	633	23	parallel	parallel	JJ
cord-350836-1enteev7	633	24	evolution	evolution	NN
cord-350836-1enteev7	633	25	at	at	IN
cord-350836-1enteev7	633	26	LGP2	LGP2	NNP
cord-350836-1enteev7	633	27	and	and	CC
cord-350836-1enteev7	633	28	RIG	rig	NN
cord-350836-1enteev7	633	29	-	-	:
cord-350836-1enteev7	633	30	I	I	NNP
cord-350836-1enteev7	633	31	Identification	identification	NN
cord-350836-1enteev7	633	32	and	and	CC
cord-350836-1enteev7	633	33	characterization	characterization	NN
cord-350836-1enteev7	633	34	of	of	IN
cord-350836-1enteev7	633	35	an	an	DT
cord-350836-1enteev7	633	36	atypical	atypical	JJ
cord-350836-1enteev7	633	37	RIG	rig	NN
cord-350836-1enteev7	634	1	-I	-i	DT
cord-350836-1enteev7	634	2	encoded	encode	VBN
cord-350836-1enteev7	634	3	by	by	IN
cord-350836-1enteev7	634	4	planarian	planarian	JJ
cord-350836-1enteev7	634	5	Dugesia	Dugesia	NNP
cord-350836-1enteev7	634	6	japonica	japonica	NN
cord-350836-1enteev7	634	7	and	and	CC
cord-350836-1enteev7	634	8	its	-PRON-	PRP$
cord-350836-1enteev7	634	9	essential	essential	JJ
cord-350836-1enteev7	634	10	role	role	NN
cord-350836-1enteev7	634	11	in	in	IN
cord-350836-1enteev7	634	12	the	the	DT
cord-350836-1enteev7	634	13	immune	immune	JJ
cord-350836-1enteev7	634	14	response	response	NN
cord-350836-1enteev7	634	15	Caenorhabditis	Caenorhabditis	NNP
cord-350836-1enteev7	634	16	elegans	elegan	VBZ
cord-350836-1enteev7	634	17	RIG-	RIG-	NNP
cord-350836-1enteev7	635	1	I	-PRON-	PRP
cord-350836-1enteev7	636	1	homolog	homolog	NN
cord-350836-1enteev7	636	2	mediates	mediate	VBZ
cord-350836-1enteev7	636	3	antiviral	antiviral	JJ
cord-350836-1enteev7	636	4	RNA	RNA	NNP
cord-350836-1enteev7	636	5	interference	interference	NN
cord-350836-1enteev7	636	6	downstream	downstream	RB
cord-350836-1enteev7	636	7	of	of	IN
cord-350836-1enteev7	636	8	dicer	dicer	NN
cord-350836-1enteev7	636	9	-	-	HYPH
cord-350836-1enteev7	636	10	dependent	dependent	JJ
cord-350836-1enteev7	636	11	biogenesis	biogenesis	NN
cord-350836-1enteev7	636	12	of	of	IN
cord-350836-1enteev7	636	13	viral	viral	JJ
cord-350836-1enteev7	636	14	small	small	JJ
cord-350836-1enteev7	636	15	interfering	interfere	VBG
cord-350836-1enteev7	636	16	RNAs	rna	NNS
cord-350836-1enteev7	636	17	Nucleic	nucleic	JJ
cord-350836-1enteev7	636	18	acid	acid	NN
cord-350836-1enteev7	636	19	-	-	HYPH
cord-350836-1enteev7	636	20	induced	induce	VBN
cord-350836-1enteev7	636	21	antiviral	antiviral	JJ
cord-350836-1enteev7	636	22	immunity	immunity	NN
cord-350836-1enteev7	636	23	in	in	IN
cord-350836-1enteev7	636	24	invertebrates	invertebrate	NNS
cord-350836-1enteev7	636	25	:	:	:
cord-350836-1enteev7	636	26	an	an	DT
cord-350836-1enteev7	636	27	evolutionary	evolutionary	JJ
cord-350836-1enteev7	636	28	perspective	perspective	NN
cord-350836-1enteev7	636	29	Non	Non	NNP
cord-350836-1enteev7	636	30	-	-	NN
cord-350836-1enteev7	636	31	self	self	NN
cord-350836-1enteev7	636	32	'	'	''
cord-350836-1enteev7	636	33	mutation	mutation	NN
cord-350836-1enteev7	636	34	:	:	:
cord-350836-1enteev7	637	1	double	double	RB
cord-350836-1enteev7	637	2	-	-	HYPH
cord-350836-1enteev7	637	3	stranded	strand	VBN
cord-350836-1enteev7	637	4	RNA	RNA	NNP
cord-350836-1enteev7	637	5	elicits	elicit	VBZ
cord-350836-1enteev7	637	6	antiviral	antiviral	JJ
cord-350836-1enteev7	637	7	pathogenic	pathogenic	JJ
cord-350836-1enteev7	637	8	response	response	NN
cord-350836-1enteev7	637	9	in	in	IN
cord-350836-1enteev7	637	10	a	a	DT
cord-350836-1enteev7	637	11	Drosophila	drosophila	JJ
cord-350836-1enteev7	637	12	model	model	NN
cord-350836-1enteev7	637	13	of	of	IN
cord-350836-1enteev7	637	14	expanded	expand	VBN
cord-350836-1enteev7	637	15	CAG	CAG	NNP
cord-350836-1enteev7	637	16	repeat	repeat	NN
cord-350836-1enteev7	637	17	neurodegenerative	neurodegenerative	JJ
cord-350836-1enteev7	637	18	diseases	disease	NNS
cord-350836-1enteev7	637	19	Plant	Plant	NNP
cord-350836-1enteev7	637	20	pattern	pattern	NN
cord-350836-1enteev7	637	21	-	-	HYPH
cord-350836-1enteev7	637	22	recognition	recognition	NN
cord-350836-1enteev7	637	23	receptors	receptor	NNS
cord-350836-1enteev7	637	24	RNA	RNA	NNP
cord-350836-1enteev7	637	25	silencing	silence	VBG
cord-350836-1enteev7	637	26	and	and	CC
cord-350836-1enteev7	637	27	its	-PRON-	PRP$
cord-350836-1enteev7	637	28	suppression	suppression	NN
cord-350836-1enteev7	637	29	:	:	:
cord-350836-1enteev7	637	30	novel	novel	JJ
cord-350836-1enteev7	637	31	insights	insight	NNS
cord-350836-1enteev7	637	32	from	from	IN
cord-350836-1enteev7	637	33	in	in	IN
cord-350836-1enteev7	637	34	planta	planta	NN
cord-350836-1enteev7	637	35	analyses	analysis	NNS
cord-350836-1enteev7	638	1	The	the	DT
cord-350836-1enteev7	638	2	immunity	immunity	NN
cord-350836-1enteev7	638	3	regulator	regulator	NN
cord-350836-1enteev7	638	4	BAK1	BAK1	NNP
cord-350836-1enteev7	638	5	contributes	contribute	VBZ
cord-350836-1enteev7	638	6	to	to	IN
cord-350836-1enteev7	638	7	resistance	resistance	NN
cord-350836-1enteev7	638	8	against	against	IN
cord-350836-1enteev7	638	9	diverse	diverse	JJ
cord-350836-1enteev7	638	10	RNA	RNA	NNP
cord-350836-1enteev7	638	11	viruses	virus	NNS
cord-350836-1enteev7	639	1	SVCV	SVCV	NNP
cord-350836-1enteev7	639	2	infection	infection	NN
cord-350836-1enteev7	639	3	triggers	trigger	VBZ
cord-350836-1enteev7	639	4	fish	fish	NN
cord-350836-1enteev7	639	5	IFN	IFN	NNP
cord-350836-1enteev7	639	6	response	response	NN
cord-350836-1enteev7	639	7	through	through	IN
cord-350836-1enteev7	639	8	RLR	RLR	NNP
cord-350836-1enteev7	639	9	signaling	signal	VBG
cord-350836-1enteev7	639	10	pathway	pathway	NN
cord-350836-1enteev7	639	11	Alternative	alternative	JJ
cord-350836-1enteev7	639	12	splicing	splice	VBG
cord-350836-1enteev7	639	13	transcripts	transcript	NNS
cord-350836-1enteev7	639	14	of	of	IN
cord-350836-1enteev7	639	15	zebrafish	zebrafish	NN
cord-350836-1enteev7	639	16	LGP2	LGP2	NNP
cord-350836-1enteev7	639	17	gene	gene	NN
cord-350836-1enteev7	639	18	differentially	differentially	RB
cord-350836-1enteev7	639	19	contribute	contribute	VBP
cord-350836-1enteev7	639	20	to	to	IN
cord-350836-1enteev7	639	21	IFN	IFN	NNP
cord-350836-1enteev7	639	22	antiviral	antiviral	JJ
cord-350836-1enteev7	639	23	response	response	NN
cord-350836-1enteev7	640	1	Inducible	inducible	JJ
cord-350836-1enteev7	640	2	MicroRNA-3570	MicroRNA-3570	NNP
cord-350836-1enteev7	640	3	feedback	feedback	NN
cord-350836-1enteev7	640	4	inhibits	inhibit	VBZ
cord-350836-1enteev7	640	5	the	the	DT
cord-350836-1enteev7	640	6	RIG	rig	NN
cord-350836-1enteev7	640	7	-	-	HYPH
cord-350836-1enteev7	640	8	I	i	NN
cord-350836-1enteev7	640	9	-	-	HYPH
cord-350836-1enteev7	640	10	dependent	dependent	JJ
cord-350836-1enteev7	640	11	innate	innate	JJ
cord-350836-1enteev7	640	12	immune	immune	JJ
cord-350836-1enteev7	640	13	response	response	NN
cord-350836-1enteev7	640	14	to	to	IN
cord-350836-1enteev7	640	15	rhabdovirus	rhabdovirus	NNP
cord-350836-1enteev7	640	16	in	in	IN
cord-350836-1enteev7	640	17	teleost	teleost	NN
cord-350836-1enteev7	640	18	fish	fish	NN
cord-350836-1enteev7	640	19	by	by	IN
cord-350836-1enteev7	640	20	targeting	target	VBG
cord-350836-1enteev7	640	21	MAVS	MAVS	NNPS
cord-350836-1enteev7	641	1	/IPS-1	/IPS-1	NFP
cord-350836-1enteev7	641	2	microRNA-210	microRNA-210	NNP
cord-350836-1enteev7	641	3	participates	participate	VBZ
cord-350836-1enteev7	641	4	in	in	IN
cord-350836-1enteev7	641	5	regulating	regulate	VBG
cord-350836-1enteev7	641	6	RIG	rig	NN
cord-350836-1enteev7	642	1	-I	-i	DT
cord-350836-1enteev7	642	2	signaling	signal	VBG
cord-350836-1enteev7	642	3	pathway	pathway	NN
cord-350836-1enteev7	642	4	via	via	IN
cord-350836-1enteev7	642	5	targeting	target	VBG
cord-350836-1enteev7	642	6	DUBA	DUBA	NNP
cord-350836-1enteev7	642	7	in	in	IN
cord-350836-1enteev7	642	8	miiuy	miiuy	NN
cord-350836-1enteev7	642	9	croaker	croaker	NN
cord-350836-1enteev7	642	10	after	after	IN
cord-350836-1enteev7	643	1	poly(I	poly(I	NNS
cord-350836-1enteev7	643	2	:	:	:
cord-350836-1enteev7	643	3	C	C	NNP
cord-350836-1enteev7	643	4	)	)	-RRB-
cord-350836-1enteev7	643	5	stimulation	stimulation	NN
cord-350836-1enteev7	643	6	MDA5	MDA5	NNP
cord-350836-1enteev7	643	7	and	and	CC
cord-350836-1enteev7	643	8	LGP2	LGP2	NNP
cord-350836-1enteev7	643	9	acts	act	VBZ
cord-350836-1enteev7	643	10	as	as	IN
cord-350836-1enteev7	643	11	a	a	DT
cord-350836-1enteev7	643	12	key	key	JJ
cord-350836-1enteev7	643	13	regulator	regulator	NN
cord-350836-1enteev7	643	14	though	though	IN
cord-350836-1enteev7	643	15	activating	activate	VBG
cord-350836-1enteev7	643	16	NF	nf	NN
cord-350836-1enteev7	643	17	-	-	HYPH
cord-350836-1enteev7	643	18	κB	κB	NNP
cord-350836-1enteev7	643	19	and	and	CC
cord-350836-1enteev7	643	20	IRF3	IRF3	NNP
cord-350836-1enteev7	643	21	in	in	IN
cord-350836-1enteev7	643	22	RLRs	rlr	NNS
cord-350836-1enteev7	643	23	signaling	signaling	NN
cord-350836-1enteev7	643	24	of	of	IN
cord-350836-1enteev7	643	25	mandarinfish	mandarinfish	NNP
cord-350836-1enteev7	643	26	Higher	Higher	NNP
cord-350836-1enteev7	643	27	antiviral	antiviral	JJ
cord-350836-1enteev7	643	28	response	response	NN
cord-350836-1enteev7	643	29	of	of	IN
cord-350836-1enteev7	643	30	RIG	rig	NN
cord-350836-1enteev7	644	1	-I	-I	.
cord-350836-1enteev7	645	1	through	through	IN
cord-350836-1enteev7	645	2	enhancing	enhance	VBG
cord-350836-1enteev7	645	3	RIG	rig	NN
cord-350836-1enteev7	645	4	-	-	:
cord-350836-1enteev7	645	5	I	I	NNP
cord-350836-1enteev7	645	6	/	/	SYM
cord-350836-1enteev7	645	7	MAVS	MAVS	NNP
cord-350836-1enteev7	645	8	-	-	HYPH
cord-350836-1enteev7	645	9	mediated	mediate	VBN
cord-350836-1enteev7	645	10	signaling	signaling	NN
cord-350836-1enteev7	645	11	by	by	IN
cord-350836-1enteev7	645	12	its	-PRON-	PRP$
cord-350836-1enteev7	645	13	long	long	JJ
cord-350836-1enteev7	645	14	insertion	insertion	NN
cord-350836-1enteev7	645	15	variant	variant	NN
cord-350836-1enteev7	645	16	in	in	IN
cord-350836-1enteev7	645	17	zebrafish	zebrafish	NN
cord-350836-1enteev7	645	18	Roles	role	NNS
cord-350836-1enteev7	645	19	of	of	IN
cord-350836-1enteev7	645	20	RIG	rig	NN
cord-350836-1enteev7	645	21	-	-	:
cord-350836-1enteev7	645	22	I	I	NNP
cord-350836-1enteev7	645	23	N	N	NNP
cord-350836-1enteev7	645	24	-	-	HYPH
cord-350836-1enteev7	645	25	terminal	terminal	NN
cord-350836-1enteev7	645	26	tandem	tandem	NN
cord-350836-1enteev7	645	27	CARD	card	NN
cord-350836-1enteev7	645	28	and	and	CC
cord-350836-1enteev7	645	29	splice	splice	NN
cord-350836-1enteev7	645	30	variant	variant	NN
cord-350836-1enteev7	645	31	in	in	IN
cord-350836-1enteev7	645	32	TRIM25-mediated	trim25-mediated	JJ
cord-350836-1enteev7	645	33	antiviral	antiviral	JJ
cord-350836-1enteev7	645	34	signal	signal	NN
cord-350836-1enteev7	645	35	transduction	transduction	NN
cord-350836-1enteev7	645	36	Activation	activation	NN
cord-350836-1enteev7	645	37	of	of	IN
cord-350836-1enteev7	645	38	duck	duck	NN
cord-350836-1enteev7	645	39	RIG	rig	NN
cord-350836-1enteev7	645	40	-	-	:
cord-350836-1enteev7	645	41	I	i	NN
cord-350836-1enteev7	645	42	by	by	IN
cord-350836-1enteev7	645	43	TRIM25	TRIM25	NNP
cord-350836-1enteev7	645	44	is	be	VBZ
cord-350836-1enteev7	645	45	independent	independent	JJ
cord-350836-1enteev7	645	46	of	of	IN
cord-350836-1enteev7	645	47	anchored	anchor	VBN
cord-350836-1enteev7	645	48	ubiquitin	ubiquitin	JJ
cord-350836-1enteev7	645	49	Expression	expression	NN
cord-350836-1enteev7	645	50	of	of	IN
cord-350836-1enteev7	645	51	immune	immune	JJ
cord-350836-1enteev7	645	52	genes	gene	NNS
cord-350836-1enteev7	645	53	RIG	rig	NN
cord-350836-1enteev7	645	54	-	-	:
cord-350836-1enteev7	645	55	I	I	NNP
cord-350836-1enteev7	645	56	and	and	CC
cord-350836-1enteev7	645	57	Mx	Mx	NNP
cord-350836-1enteev7	645	58	in	in	IN
cord-350836-1enteev7	645	59	mallard	mallard	NNP
cord-350836-1enteev7	645	60	ducks	duck	NNS
cord-350836-1enteev7	645	61	infected	infect	VBN
cord-350836-1enteev7	645	62	with	with	IN
cord-350836-1enteev7	645	63	low	low	JJ
cord-350836-1enteev7	645	64	pathogenic	pathogenic	JJ
cord-350836-1enteev7	645	65	avian	avian	JJ
cord-350836-1enteev7	645	66	influenza	influenza	NN
cord-350836-1enteev7	645	67	(	(	-LRB-
cord-350836-1enteev7	645	68	LPAI	LPAI	NNP
cord-350836-1enteev7	645	69	)	)	-RRB-
cord-350836-1enteev7	645	70	:	:	:
cord-350836-1enteev7	645	71	a	a	DT
cord-350836-1enteev7	645	72	dataset	dataset	NN
cord-350836-1enteev7	645	73	Duck	Duck	NNP
cord-350836-1enteev7	645	74	RIG	rig	NN
cord-350836-1enteev7	646	1	-I	-i	WDT
cord-350836-1enteev7	646	2	restricts	restrict	VBZ
cord-350836-1enteev7	646	3	duck	duck	NN
cord-350836-1enteev7	646	4	enteritis	enteritis	NN
cord-350836-1enteev7	646	5	virus	virus	NN
cord-350836-1enteev7	646	6	infection	infection	NN
cord-350836-1enteev7	647	1	In	in	IN
cord-350836-1enteev7	647	2	vivo	vivo	NN
cord-350836-1enteev7	647	3	cellular	cellular	JJ
cord-350836-1enteev7	647	4	and	and	CC
cord-350836-1enteev7	647	5	molecular	molecular	JJ
cord-350836-1enteev7	647	6	study	study	NN
cord-350836-1enteev7	647	7	on	on	IN
cord-350836-1enteev7	647	8	duck	duck	NN
cord-350836-1enteev7	647	9	spleen	spleen	NNS
cord-350836-1enteev7	647	10	infected	infect	VBN
cord-350836-1enteev7	647	11	by	by	IN
cord-350836-1enteev7	647	12	duck	duck	NN
cord-350836-1enteev7	647	13	Tembusu	Tembusu	NNP
cord-350836-1enteev7	647	14	virus	virus	NN
cord-350836-1enteev7	647	15	Identification	identification	NN
cord-350836-1enteev7	647	16	and	and	CC
cord-350836-1enteev7	647	17	expression	expression	NN
cord-350836-1enteev7	647	18	profiling	profile	VBG
cord-350836-1enteev7	647	19	analysis	analysis	NN
cord-350836-1enteev7	647	20	of	of	IN
cord-350836-1enteev7	647	21	goose	goose	NN
cord-350836-1enteev7	647	22	melanoma	melanoma	NN
cord-350836-1enteev7	647	23	differentiation	differentiation	NN
cord-350836-1enteev7	647	24	associated	associate	VBD
cord-350836-1enteev7	647	25	gene	gene	NN
cord-350836-1enteev7	647	26	5	5	CD
cord-350836-1enteev7	648	1	(	(	-LRB-
cord-350836-1enteev7	648	2	MDA5	MDA5	NNP
cord-350836-1enteev7	648	3	)	)	-RRB-
cord-350836-1enteev7	648	4	gene	gene	NN
cord-350836-1enteev7	648	5	Goose	Goose	NNP
cord-350836-1enteev7	648	6	MAVS	MAVS	NNP
cord-350836-1enteev7	648	7	functions	function	VBZ
cord-350836-1enteev7	648	8	in	in	IN
cord-350836-1enteev7	649	1	RIG	rig	NN
cord-350836-1enteev7	649	2	-	-	HYPH
cord-350836-1enteev7	649	3	I	-PRON-	PRP
cord-350836-1enteev7	649	4	-	-	HYPH
cord-350836-1enteev7	649	5	mediated	mediate	VBN
cord-350836-1enteev7	649	6	IFN	IFN	NNP
cord-350836-1enteev7	649	7	-	-	HYPH
cord-350836-1enteev7	649	8	β	β	NNP
cord-350836-1enteev7	649	9	signaling	signal	VBG
cord-350836-1enteev7	649	10	activation	activation	NN
cord-350836-1enteev7	649	11	Characterization	characterization	NN
cord-350836-1enteev7	649	12	of	of	IN
cord-350836-1enteev7	649	13	chicken	chicken	NN
cord-350836-1enteev7	649	14	Mda5	Mda5	NNP
cord-350836-1enteev7	649	15	activity	activity	NN
cord-350836-1enteev7	649	16	:	:	:
cord-350836-1enteev7	649	17	regulation	regulation	NN
cord-350836-1enteev7	649	18	of	of	IN
cord-350836-1enteev7	649	19	IFNβ	IFNβ	NNS
cord-350836-1enteev7	649	20	in	in	IN
cord-350836-1enteev7	649	21	the	the	DT
cord-350836-1enteev7	649	22	absence	absence	NN
cord-350836-1enteev7	649	23	of	of	IN
cord-350836-1enteev7	649	24	RIG	rig	NN
cord-350836-1enteev7	650	1	-I	-i	DT
cord-350836-1enteev7	650	2	functionality	functionality	NN
cord-350836-1enteev7	651	1	Chicken	chicken	NN
cord-350836-1enteev7	651	2	cells	cell	NNS
cord-350836-1enteev7	651	3	sense	sense	VBP
cord-350836-1enteev7	651	4	influenza	influenza	NN
cord-350836-1enteev7	651	5	A	a	DT
cord-350836-1enteev7	651	6	virus	virus	NN
cord-350836-1enteev7	651	7	infection	infection	NN
cord-350836-1enteev7	651	8	through	through	IN
cord-350836-1enteev7	651	9	MDA5	MDA5	NNP
cord-350836-1enteev7	651	10	and	and	CC
cord-350836-1enteev7	651	11	CARDIF	CARDIF	NNP
cord-350836-1enteev7	651	12	signaling	signal	VBG
cord-350836-1enteev7	651	13	involving	involve	VBG
cord-350836-1enteev7	651	14	LGP2	LGP2	NNP
cord-350836-1enteev7	651	15	Chicken	Chicken	NNP
cord-350836-1enteev7	651	16	MDA5	MDA5	NNP
cord-350836-1enteev7	651	17	senses	sense	VBZ
cord-350836-1enteev7	651	18	short	short	JJ
cord-350836-1enteev7	651	19	double	double	RB
cord-350836-1enteev7	651	20	-	-	HYPH
cord-350836-1enteev7	651	21	stranded	strand	VBN
cord-350836-1enteev7	651	22	RNA	RNA	NNP
cord-350836-1enteev7	651	23	with	with	IN
cord-350836-1enteev7	651	24	implications	implication	NNS
cord-350836-1enteev7	651	25	for	for	IN
cord-350836-1enteev7	651	26	antiviral	antiviral	JJ
cord-350836-1enteev7	651	27	response	response	NN
cord-350836-1enteev7	651	28	against	against	IN
cord-350836-1enteev7	651	29	avian	avian	JJ
cord-350836-1enteev7	651	30	influenza	influenza	NN
cord-350836-1enteev7	651	31	viruses	virus	NNS
cord-350836-1enteev7	651	32	in	in	IN
cord-350836-1enteev7	651	33	chicken	chicken	NN
cord-350836-1enteev7	651	34	Cloning	cloning	NN
cord-350836-1enteev7	651	35	,	,	,
cord-350836-1enteev7	651	36	expression	expression	NN
cord-350836-1enteev7	651	37	and	and	CC
cord-350836-1enteev7	651	38	bioinformatics	bioinformatics	NN
cord-350836-1enteev7	651	39	analysis	analysis	NN
cord-350836-1enteev7	651	40	of	of	IN
cord-350836-1enteev7	651	41	a	a	DT
cord-350836-1enteev7	651	42	putative	putative	JJ
cord-350836-1enteev7	651	43	pigeon	pigeon	NN
cord-350836-1enteev7	651	44	melanoma	melanoma	NN
cord-350836-1enteev7	651	45	differentiation	differentiation	NN
cord-350836-1enteev7	651	46	-	-	HYPH
cord-350836-1enteev7	651	47	associated	associate	VBN
cord-350836-1enteev7	651	48	gene	gene	NN
cord-350836-1enteev7	651	49	5	5	CD
cord-350836-1enteev7	651	50	Loss	loss	NN
cord-350836-1enteev7	651	51	of	of	IN
cord-350836-1enteev7	651	52	RIG	rig	NN
cord-350836-1enteev7	651	53	-	-	:
cord-350836-1enteev7	651	54	I	-PRON-	PRP
cord-350836-1enteev7	651	55	leads	lead	VBZ
cord-350836-1enteev7	651	56	to	to	IN
cord-350836-1enteev7	651	57	a	a	DT
cord-350836-1enteev7	651	58	functional	functional	JJ
cord-350836-1enteev7	651	59	replacement	replacement	NN
cord-350836-1enteev7	651	60	with	with	IN
cord-350836-1enteev7	651	61	MDA5	MDA5	NNP
cord-350836-1enteev7	651	62	in	in	IN
cord-350836-1enteev7	651	63	the	the	DT
cord-350836-1enteev7	651	64	Chinese	chinese	JJ
cord-350836-1enteev7	651	65	tree	tree	NN
cord-350836-1enteev7	651	66	shrew	shrew	NN
cord-350836-1enteev7	652	1	TRIM25	trim25	CD
cord-350836-1enteev7	652	2	identification	identification	NN
cord-350836-1enteev7	652	3	in	in	IN
cord-350836-1enteev7	652	4	the	the	DT
cord-350836-1enteev7	652	5	Chinese	chinese	JJ
cord-350836-1enteev7	652	6	goose	goose	NN
cord-350836-1enteev7	652	7	:	:	:
cord-350836-1enteev7	652	8	gene	gene	NN
cord-350836-1enteev7	652	9	structure	structure	NN
cord-350836-1enteev7	652	10	,	,	,
cord-350836-1enteev7	652	11	tissue	tissue	NN
cord-350836-1enteev7	652	12	expression	expression	NN
cord-350836-1enteev7	652	13	profiles	profile	NNS
cord-350836-1enteev7	652	14	,	,	,
cord-350836-1enteev7	652	15	and	and	CC
cord-350836-1enteev7	652	16	antiviral	antiviral	JJ
cord-350836-1enteev7	652	17	immune	immune	JJ
cord-350836-1enteev7	652	18	responses	response	NNS
cord-350836-1enteev7	652	19	in	in	IN
cord-350836-1enteev7	652	20	vivo	vivo	NN
cord-350836-1enteev7	652	21	and	and	CC
cord-350836-1enteev7	652	22	in	in	IN
cord-350836-1enteev7	652	23	vitro	vitro	FW
cord-350836-1enteev7	652	24	Expression	expression	NN
cord-350836-1enteev7	652	25	and	and	CC
cord-350836-1enteev7	652	26	functional	functional	JJ
cord-350836-1enteev7	652	27	characterization	characterization	NN
cord-350836-1enteev7	652	28	of	of	IN
cord-350836-1enteev7	652	29	the	the	DT
cord-350836-1enteev7	652	30	RIG	rig	NN
cord-350836-1enteev7	652	31	-	-	HYPH
cord-350836-1enteev7	652	32	I	i	NN
cord-350836-1enteev7	652	33	-	-	HYPH
cord-350836-1enteev7	652	34	like	like	JJ
cord-350836-1enteev7	652	35	receptors	receptor	NNS
cord-350836-1enteev7	652	36	MDA5	MDA5	NNP
cord-350836-1enteev7	652	37	and	and	CC
cord-350836-1enteev7	652	38	LGP2	LGP2	NNP
cord-350836-1enteev7	652	39	in	in	IN
cord-350836-1enteev7	652	40	Rainbow	Rainbow	NNP
cord-350836-1enteev7	652	41	trout	trout	NN
cord-350836-1enteev7	653	1	(	(	-LRB-
cord-350836-1enteev7	653	2	Oncorhynchus	Oncorhynchus	NNP
cord-350836-1enteev7	653	3	mykiss	mykiss	NN
cord-350836-1enteev7	653	4	)	)	-RRB-
cord-350836-1enteev7	654	1	Influenza	influenza	NN
cord-350836-1enteev7	654	2	virus	virus	NN
cord-350836-1enteev7	654	3	adaptation	adaptation	NN
cord-350836-1enteev7	654	4	PB2	PB2	NNP
cord-350836-1enteev7	654	5	-	-	:
cord-350836-1enteev7	654	6	627	627	CD
cord-350836-1enteev7	654	7	K	K	NNP
cord-350836-1enteev7	654	8	modulates	modulate	VBZ
cord-350836-1enteev7	654	9	nucleocapsid	nucleocapsid	NNP
cord-350836-1enteev7	654	10	inhibition	inhibition	NN
cord-350836-1enteev7	654	11	by	by	IN
cord-350836-1enteev7	654	12	the	the	DT
cord-350836-1enteev7	654	13	pathogen	pathogen	NN
cord-350836-1enteev7	654	14	sensor	sensor	NN
cord-350836-1enteev7	654	15	RIG	rig	NN
cord-350836-1enteev7	654	16	-	-	:
cord-350836-1enteev7	654	17	I	I	NNP
cord-350836-1enteev7	654	18	Multiple	multiple	JJ
cord-350836-1enteev7	654	19	functions	function	NNS
cord-350836-1enteev7	654	20	of	of	IN
cord-350836-1enteev7	654	21	DDX3	DDX3	NNP
cord-350836-1enteev7	654	22	RNA	RNA	NNP
cord-350836-1enteev7	654	23	helicase	helicase	NN
cord-350836-1enteev7	654	24	in	in	IN
cord-350836-1enteev7	654	25	gene	gene	NN
cord-350836-1enteev7	654	26	regulation	regulation	NN
cord-350836-1enteev7	654	27	,	,	,
cord-350836-1enteev7	654	28	tumorigenesis	tumorigenesis	NN
cord-350836-1enteev7	654	29	,	,	,
cord-350836-1enteev7	654	30	and	and	CC
cord-350836-1enteev7	654	31	viral	viral	JJ
cord-350836-1enteev7	654	32	infection	infection	NN
cord-350836-1enteev7	655	1	RNA	RNA	NNP
cord-350836-1enteev7	655	2	helicase	helicase	NNP
cord-350836-1enteev7	655	3	DDX3	DDX3	NNP
cord-350836-1enteev7	655	4	:	:	:
cord-350836-1enteev7	655	5	at	at	IN
cord-350836-1enteev7	655	6	the	the	DT
cord-350836-1enteev7	655	7	crossroad	crossroad	NN
cord-350836-1enteev7	655	8	of	of	IN
cord-350836-1enteev7	655	9	viral	viral	JJ
cord-350836-1enteev7	655	10	replication	replication	NN
cord-350836-1enteev7	655	11	and	and	CC
cord-350836-1enteev7	655	12	antiviral	antiviral	JJ
cord-350836-1enteev7	655	13	immunity	immunity	NN
cord-350836-1enteev7	655	14	HIV-1	HIV-1	NNP
cord-350836-1enteev7	655	15	blocks	block	VBZ
cord-350836-1enteev7	655	16	the	the	DT
cord-350836-1enteev7	655	17	signaling	signal	VBG
cord-350836-1enteev7	655	18	adaptor	adaptor	NN
cord-350836-1enteev7	655	19	MAVS	MAVS	NNPS
cord-350836-1enteev7	655	20	to	to	TO
cord-350836-1enteev7	655	21	evade	evade	VB
cord-350836-1enteev7	655	22	antiviral	antiviral	JJ
cord-350836-1enteev7	655	23	host	host	NN
cord-350836-1enteev7	655	24	defense	defense	NN
cord-350836-1enteev7	655	25	after	after	IN
cord-350836-1enteev7	655	26	sensing	sensing	NN
cord-350836-1enteev7	655	27	of	of	IN
cord-350836-1enteev7	655	28	abortive	abortive	JJ
cord-350836-1enteev7	655	29	HIV-1	HIV-1	NNP
cord-350836-1enteev7	655	30	RNA	RNA	NNP
cord-350836-1enteev7	655	31	by	by	IN
cord-350836-1enteev7	655	32	the	the	DT
cord-350836-1enteev7	655	33	host	host	NN
cord-350836-1enteev7	655	34	helicase	helicase	NN
cord-350836-1enteev7	655	35	DDX3	DDX3	NNP
cord-350836-1enteev7	656	1	The	the	DT
cord-350836-1enteev7	656	2	RNA	RNA	NNP
cord-350836-1enteev7	656	3	helicase	helicase	NN
cord-350836-1enteev7	656	4	DDX3X	DDX3X	NNPS
cord-350836-1enteev7	656	5	is	be	VBZ
cord-350836-1enteev7	656	6	an	an	DT
cord-350836-1enteev7	656	7	essential	essential	JJ
cord-350836-1enteev7	656	8	mediator	mediator	NN
cord-350836-1enteev7	656	9	of	of	IN
cord-350836-1enteev7	656	10	innate	innate	JJ
cord-350836-1enteev7	656	11	antimicrobial	antimicrobial	JJ
cord-350836-1enteev7	656	12	immunity	immunity	NN
cord-350836-1enteev7	656	13	DHX9	DHX9	NNP
cord-350836-1enteev7	656	14	pairs	pair	NNS
cord-350836-1enteev7	656	15	with	with	IN
cord-350836-1enteev7	656	16	IPS-1	IPS-1	NNP
cord-350836-1enteev7	656	17	to	to	TO
cord-350836-1enteev7	656	18	sense	sense	VB
cord-350836-1enteev7	656	19	double	double	RB
cord-350836-1enteev7	656	20	-	-	HYPH
cord-350836-1enteev7	656	21	stranded	strand	VBN
cord-350836-1enteev7	656	22	RNA	RNA	NNP
cord-350836-1enteev7	656	23	in	in	IN
cord-350836-1enteev7	656	24	myeloid	myeloid	JJ
cord-350836-1enteev7	656	25	dendritic	dendritic	JJ
cord-350836-1enteev7	656	26	cells	cell	NNS
cord-350836-1enteev7	657	1	DHX15	DHX15	NNP
cord-350836-1enteev7	657	2	senses	sense	VBZ
cord-350836-1enteev7	657	3	doublestranded	doublestrande	VBD
cord-350836-1enteev7	657	4	RNA	RNA	NNP
cord-350836-1enteev7	657	5	in	in	IN
cord-350836-1enteev7	657	6	myeloid	myeloid	JJ
cord-350836-1enteev7	657	7	dendritic	dendritic	JJ
cord-350836-1enteev7	657	8	cells	cell	NNS
cord-350836-1enteev7	657	9	DDX1	DDX1	NNP
cord-350836-1enteev7	657	10	,	,	,
cord-350836-1enteev7	657	11	DDX21	DDX21	NNP
cord-350836-1enteev7	657	12	,	,	,
cord-350836-1enteev7	657	13	and	and	CC
cord-350836-1enteev7	657	14	DHX36	DHX36	NNP
cord-350836-1enteev7	657	15	helicases	helicase	NNS
cord-350836-1enteev7	657	16	form	form	VB
cord-350836-1enteev7	657	17	a	a	DT
cord-350836-1enteev7	657	18	complex	complex	NN
cord-350836-1enteev7	657	19	with	with	IN
cord-350836-1enteev7	657	20	the	the	DT
cord-350836-1enteev7	657	21	adaptor	adaptor	NN
cord-350836-1enteev7	657	22	molecule	molecule	NN
cord-350836-1enteev7	657	23	TRIF	TRIF	NNP
cord-350836-1enteev7	657	24	to	to	TO
cord-350836-1enteev7	657	25	sense	sense	VB
cord-350836-1enteev7	657	26	dsRNA	dsrna	JJ
cord-350836-1enteev7	657	27	in	in	IN
cord-350836-1enteev7	657	28	dendritic	dendritic	JJ
cord-350836-1enteev7	657	29	cells	cell	NNS
cord-350836-1enteev7	658	1	The	the	DT
cord-350836-1enteev7	658	2	interaction	interaction	NN
cord-350836-1enteev7	658	3	between	between	IN
cord-350836-1enteev7	658	4	the	the	DT
cord-350836-1enteev7	658	5	helicase	helicase	NN
cord-350836-1enteev7	658	6	DHX33	DHX33	NNP
cord-350836-1enteev7	658	7	and	and	CC
cord-350836-1enteev7	658	8	IPS-1	IPS-1	NNP
cord-350836-1enteev7	658	9	as	as	IN
cord-350836-1enteev7	658	10	a	a	DT
cord-350836-1enteev7	658	11	novel	novel	JJ
cord-350836-1enteev7	658	12	pathway	pathway	NN
cord-350836-1enteev7	658	13	to	to	TO
cord-350836-1enteev7	658	14	sense	sense	VB
cord-350836-1enteev7	658	15	double	double	RB
cord-350836-1enteev7	658	16	-	-	HYPH
cord-350836-1enteev7	658	17	stranded	strand	VBN
cord-350836-1enteev7	658	18	RNA	RNA	NNP
cord-350836-1enteev7	658	19	and	and	CC
cord-350836-1enteev7	658	20	RNA	RNA	NNP
cord-350836-1enteev7	658	21	viruses	virus	NNS
cord-350836-1enteev7	658	22	in	in	IN
cord-350836-1enteev7	658	23	myeloid	myeloid	JJ
cord-350836-1enteev7	658	24	dendritic	dendritic	JJ
cord-350836-1enteev7	658	25	cells	cell	NNS
cord-350836-1enteev7	659	1	DDX19	DDX19	NNP
cord-350836-1enteev7	659	2	inhibits	inhibit	VBZ
cord-350836-1enteev7	659	3	type	type	NN
cord-350836-1enteev7	660	1	I	-PRON-	PRP
cord-350836-1enteev7	661	1	interferon	interferon	NN
cord-350836-1enteev7	661	2	production	production	NN
cord-350836-1enteev7	661	3	by	by	IN
cord-350836-1enteev7	661	4	disrupting	disrupt	VBG
cord-350836-1enteev7	661	5	TBK1-IKKε	TBK1-IKKε	NNP
cord-350836-1enteev7	661	6	-	-	HYPH
cord-350836-1enteev7	661	7	IRF3	IRF3	NNP
cord-350836-1enteev7	661	8	interactions	interaction	NNS
cord-350836-1enteev7	661	9	and	and	CC
cord-350836-1enteev7	661	10	promoting	promote	VBG
cord-350836-1enteev7	661	11	TBK1	TBK1	NNP
cord-350836-1enteev7	661	12	and	and	CC
cord-350836-1enteev7	661	13	IKKε	IKKε	NNP
cord-350836-1enteev7	661	14	degradation	degradation	NN
cord-350836-1enteev7	661	15	DDX3	DDX3	NNP
cord-350836-1enteev7	661	16	suppresses	suppress	VBZ
cord-350836-1enteev7	661	17	type	type	NN
cord-350836-1enteev7	661	18	I	-PRON-	PRP
cord-350836-1enteev7	661	19	interferons	interferon	NNS
cord-350836-1enteev7	661	20	and	and	CC
cord-350836-1enteev7	661	21	favors	favor	VBZ
cord-350836-1enteev7	661	22	viral	viral	JJ
cord-350836-1enteev7	661	23	replication	replication	NN
cord-350836-1enteev7	661	24	during	during	IN
cord-350836-1enteev7	661	25	Arenavirus	Arenavirus	NNP
cord-350836-1enteev7	661	26	infection	infection	NN
cord-350836-1enteev7	661	27	Codegradation	Codegradation	NNP
cord-350836-1enteev7	661	28	of	of	IN
cord-350836-1enteev7	661	29	interferon	interferon	NN
cord-350836-1enteev7	661	30	signaling	signal	VBG
cord-350836-1enteev7	661	31	factor	factor	NN
cord-350836-1enteev7	661	32	DDX3	DDX3	NNP
cord-350836-1enteev7	661	33	by	by	IN
cord-350836-1enteev7	661	34	PB1-F2	PB1-F2	NNP
cord-350836-1enteev7	661	35	as	as	IN
cord-350836-1enteev7	661	36	a	a	DT
cord-350836-1enteev7	661	37	basis	basis	NN
cord-350836-1enteev7	661	38	for	for	IN
cord-350836-1enteev7	661	39	high	high	JJ
cord-350836-1enteev7	661	40	virulence	virulence	NN
cord-350836-1enteev7	661	41	of	of	IN
cord-350836-1enteev7	661	42	1918	1918	CD
cord-350836-1enteev7	661	43	pandemic	pandemic	NN
cord-350836-1enteev7	661	44	influenza	influenza	NN
cord-350836-1enteev7	662	1	The	the	DT
cord-350836-1enteev7	662	2	DEAH	DEAH	NNP
cord-350836-1enteev7	662	3	-	-	HYPH
cord-350836-1enteev7	662	4	box	box	NN
cord-350836-1enteev7	662	5	RNA	RNA	NNP
cord-350836-1enteev7	662	6	helicase	helicase	NN
cord-350836-1enteev7	662	7	DHX15	DHX15	NNP
cord-350836-1enteev7	662	8	activates	activate	VBZ
cord-350836-1enteev7	663	1	NF	nf	NN
cord-350836-1enteev7	663	2	-	-	HYPH
cord-350836-1enteev7	663	3	κB	κB	NNP
cord-350836-1enteev7	663	4	and	and	CC
cord-350836-1enteev7	663	5	MAPK	MAPK	NNP
cord-350836-1enteev7	663	6	signaling	signal	VBG
cord-350836-1enteev7	663	7	downstream	downstream	RB
cord-350836-1enteev7	663	8	of	of	IN
cord-350836-1enteev7	663	9	MAVS	MAVS	NNPS
cord-350836-1enteev7	663	10	during	during	IN
cord-350836-1enteev7	663	11	antiviral	antiviral	JJ
cord-350836-1enteev7	663	12	responses	response	NNS
cord-350836-1enteev7	663	13	DDX60	DDX60	NNP
cord-350836-1enteev7	663	14	,	,	,
cord-350836-1enteev7	663	15	a	a	DT
cord-350836-1enteev7	663	16	DEXD	DEXD	NNP
cord-350836-1enteev7	663	17	/	/	SYM
cord-350836-1enteev7	663	18	H	h	NN
cord-350836-1enteev7	663	19	box	box	NN
cord-350836-1enteev7	663	20	helicase	helicase	NN
cord-350836-1enteev7	663	21	,	,	,
cord-350836-1enteev7	663	22	is	be	VBZ
cord-350836-1enteev7	663	23	a	a	DT
cord-350836-1enteev7	663	24	novel	novel	JJ
cord-350836-1enteev7	663	25	antiviral	antiviral	JJ
cord-350836-1enteev7	663	26	factor	factor	NN
cord-350836-1enteev7	663	27	promoting	promote	VBG
cord-350836-1enteev7	663	28	RIG	rig	NN
cord-350836-1enteev7	663	29	-	-	HYPH
cord-350836-1enteev7	663	30	I	i	NN
cord-350836-1enteev7	663	31	-	-	HYPH
cord-350836-1enteev7	663	32	like	like	JJ
cord-350836-1enteev7	663	33	receptor	receptor	NN
cord-350836-1enteev7	663	34	-	-	HYPH
cord-350836-1enteev7	663	35	mediated	mediate	VBN
cord-350836-1enteev7	663	36	signaling	signal	VBG
cord-350836-1enteev7	663	37	DDX60	DDX60	NNP
cord-350836-1enteev7	663	38	is	be	VBZ
cord-350836-1enteev7	663	39	involved	involve	VBN
cord-350836-1enteev7	663	40	in	in	IN
cord-350836-1enteev7	663	41	RIG	rig	NN
cord-350836-1enteev7	663	42	-	-	HYPH
cord-350836-1enteev7	663	43	I	i	NN
cord-350836-1enteev7	663	44	-	-	HYPH
cord-350836-1enteev7	663	45	dependent	dependent	JJ
cord-350836-1enteev7	663	46	and	and	CC
cord-350836-1enteev7	663	47	independent	independent	JJ
cord-350836-1enteev7	663	48	antiviral	antiviral	JJ
cord-350836-1enteev7	663	49	responses	response	NNS
cord-350836-1enteev7	663	50	,	,	,
cord-350836-1enteev7	663	51	and	and	CC
cord-350836-1enteev7	663	52	its	-PRON-	PRP$
cord-350836-1enteev7	663	53	function	function	NN
cord-350836-1enteev7	663	54	is	be	VBZ
cord-350836-1enteev7	663	55	attenuated	attenuate	VBN
cord-350836-1enteev7	663	56	by	by	IN
cord-350836-1enteev7	663	57	virus	virus	NN
cord-350836-1enteev7	663	58	-	-	HYPH
cord-350836-1enteev7	663	59	induced	induce	VBN
cord-350836-1enteev7	663	60	EGFR	EGFR	NNP
cord-350836-1enteev7	663	61	activation	activation	NN
cord-350836-1enteev7	663	62	DHX29	DHX29	NNS
cord-350836-1enteev7	663	63	functions	function	NNS
cord-350836-1enteev7	663	64	as	as	IN
cord-350836-1enteev7	663	65	an	an	DT
cord-350836-1enteev7	663	66	RNA	RNA	NNP
cord-350836-1enteev7	663	67	cosensor	cosensor	NN
cord-350836-1enteev7	663	68	for	for	IN
cord-350836-1enteev7	663	69	MDA5-mediated	MDA5-mediated	NNP
cord-350836-1enteev7	663	70	EMCV	EMCV	NNP
cord-350836-1enteev7	663	71	-	-	HYPH
cord-350836-1enteev7	663	72	specific	specific	JJ
cord-350836-1enteev7	663	73	antiviral	antiviral	JJ
cord-350836-1enteev7	663	74	immunity	immunity	NN
cord-350836-1enteev7	663	75	Activation	activation	NN
cord-350836-1enteev7	663	76	of	of	IN
cord-350836-1enteev7	663	77	RIG	rig	NN
cord-350836-1enteev7	663	78	-	-	:
cord-350836-1enteev7	663	79	I	-PRON-	PRP
cord-350836-1enteev7	663	80	signaling	signal	VBG
cord-350836-1enteev7	663	81	to	to	TO
cord-350836-1enteev7	663	82	increase	increase	VB
cord-350836-1enteev7	663	83	the	the	DT
cord-350836-1enteev7	663	84	pro	pro	JJ
cord-350836-1enteev7	663	85	-	-	JJ
cord-350836-1enteev7	663	86	inflammatory	inflammatory	JJ
cord-350836-1enteev7	663	87	phenotype	phenotype	NN
cord-350836-1enteev7	663	88	of	of	IN
cord-350836-1enteev7	663	89	a	a	DT
cord-350836-1enteev7	663	90	tumor	tumor	NN
cord-350836-1enteev7	663	91	Immunotherapeutic	immunotherapeutic	JJ
cord-350836-1enteev7	663	92	effects	effect	NNS
cord-350836-1enteev7	663	93	of	of	IN
cord-350836-1enteev7	663	94	intratumoral	intratumoral	JJ
cord-350836-1enteev7	663	95	nanoplexed	nanoplexed	NNP
cord-350836-1enteev7	663	96	poly	poly	NNP
cord-350836-1enteev7	664	1	I	-PRON-	PRP
cord-350836-1enteev7	664	2	:	:	:
cord-350836-1enteev7	664	3	C	C	NNP
cord-350836-1enteev7	664	4	RIG	rig	NN
cord-350836-1enteev7	664	5	-	-	HYPH
cord-350836-1enteev7	664	6	I	i	NN
cord-350836-1enteev7	664	7	-	-	HYPH
cord-350836-1enteev7	664	8	like	like	JJ
cord-350836-1enteev7	664	9	receptors	receptor	NNS
cord-350836-1enteev7	664	10	as	as	IN
cord-350836-1enteev7	664	11	novel	novel	JJ
cord-350836-1enteev7	664	12	targets	target	NNS
cord-350836-1enteev7	664	13	for	for	IN
cord-350836-1enteev7	664	14	panantivirals	panantiviral	NNS
cord-350836-1enteev7	664	15	and	and	CC
cord-350836-1enteev7	664	16	vaccine	vaccine	NN
cord-350836-1enteev7	664	17	adjuvants	adjuvant	NNS
cord-350836-1enteev7	664	18	against	against	IN
cord-350836-1enteev7	664	19	emerging	emerge	VBG
cord-350836-1enteev7	664	20	and	and	CC
cord-350836-1enteev7	664	21	re	re	VB
cord-350836-1enteev7	664	22	-	-	JJ
cord-350836-1enteev7	664	23	emerging	emerge	VBG
cord-350836-1enteev7	664	24	viral	viral	JJ
cord-350836-1enteev7	664	25	infections	infection	NNS
cord-350836-1enteev7	664	26	The	the	DT
cord-350836-1enteev7	664	27	authors	author	NNS
cord-350836-1enteev7	664	28	declare	declare	VBP
cord-350836-1enteev7	664	29	that	that	IN
cord-350836-1enteev7	664	30	the	the	DT
cord-350836-1enteev7	664	31	research	research	NN
cord-350836-1enteev7	664	32	was	be	VBD
cord-350836-1enteev7	664	33	conducted	conduct	VBN
cord-350836-1enteev7	664	34	in	in	IN
cord-350836-1enteev7	664	35	the	the	DT
cord-350836-1enteev7	664	36	absence	absence	NN
cord-350836-1enteev7	664	37	of	of	IN
cord-350836-1enteev7	664	38	any	any	DT
cord-350836-1enteev7	664	39	commercial	commercial	JJ
cord-350836-1enteev7	664	40	or	or	CC
cord-350836-1enteev7	664	41	financial	financial	JJ
cord-350836-1enteev7	664	42	relationships	relationship	NNS
cord-350836-1enteev7	664	43	that	that	WDT
cord-350836-1enteev7	664	44	could	could	MD
cord-350836-1enteev7	664	45	be	be	VB
cord-350836-1enteev7	664	46	construed	construe	VBN
cord-350836-1enteev7	664	47	as	as	IN
cord-350836-1enteev7	664	48	a	a	DT
cord-350836-1enteev7	664	49	potential	potential	JJ
cord-350836-1enteev7	664	50	conflict	conflict	NN
cord-350836-1enteev7	664	51	of	of	IN
cord-350836-1enteev7	664	52	interest	interest	NN
cord-350836-1enteev7	664	53	.	.	.
cord-350836-1enteev7	665	1	Copyright	copyright	NN
cord-350836-1enteev7	665	2	©	©	NNP
cord-350836-1enteev7	665	3	2019	2019	CD
cord-350836-1enteev7	665	4	Brisse	Brisse	NNP
cord-350836-1enteev7	665	5	and	and	CC
cord-350836-1enteev7	665	6	Ly	Ly	NNP
cord-350836-1enteev7	665	7	.	.	.
cord-350836-1enteev7	666	1	This	this	DT
cord-350836-1enteev7	666	2	is	be	VBZ
cord-350836-1enteev7	666	3	an	an	DT
cord-350836-1enteev7	666	4	open	open	JJ
cord-350836-1enteev7	666	5	-	-	HYPH
cord-350836-1enteev7	666	6	access	access	NN
cord-350836-1enteev7	666	7	article	article	NN
cord-350836-1enteev7	666	8	distributed	distribute	VBN
cord-350836-1enteev7	666	9	under	under	IN
cord-350836-1enteev7	666	10	the	the	DT
cord-350836-1enteev7	666	11	terms	term	NNS
cord-350836-1enteev7	666	12	of	of	IN
cord-350836-1enteev7	666	13	the	the	DT
cord-350836-1enteev7	666	14	Creative	Creative	NNP
cord-350836-1enteev7	666	15	Commons	Commons	NNP
cord-350836-1enteev7	666	16	Attribution	Attribution	NNP
cord-350836-1enteev7	666	17	License	License	NNP
cord-350836-1enteev7	666	18	(	(	-LRB-
cord-350836-1enteev7	666	19	CC	CC	NNP
cord-350836-1enteev7	666	20	BY	BY	NNP
cord-350836-1enteev7	666	21	)	)	-RRB-
cord-350836-1enteev7	666	22	.	.	.
cord-350836-1enteev7	667	1	The	the	DT
cord-350836-1enteev7	667	2	use	use	NN
cord-350836-1enteev7	667	3	,	,	,
cord-350836-1enteev7	667	4	distribution	distribution	NN
cord-350836-1enteev7	667	5	or	or	CC
cord-350836-1enteev7	667	6	reproduction	reproduction	NN
cord-350836-1enteev7	667	7	in	in	IN
cord-350836-1enteev7	667	8	other	other	JJ
cord-350836-1enteev7	667	9	forums	forum	NNS
cord-350836-1enteev7	667	10	is	be	VBZ
cord-350836-1enteev7	667	11	permitted	permit	VBN
cord-350836-1enteev7	667	12	,	,	,
cord-350836-1enteev7	667	13	provided	provide	VBD
cord-350836-1enteev7	667	14	the	the	DT
cord-350836-1enteev7	667	15	original	original	JJ
cord-350836-1enteev7	667	16	author(s	author(s	NNP
cord-350836-1enteev7	667	17	)	)	-RRB-
cord-350836-1enteev7	667	18	and	and	CC
cord-350836-1enteev7	667	19	the	the	DT
cord-350836-1enteev7	667	20	copyright	copyright	NN
cord-350836-1enteev7	667	21	owner(s	owner(s	NNP
cord-350836-1enteev7	667	22	)	)	-RRB-
cord-350836-1enteev7	667	23	are	be	VBP
cord-350836-1enteev7	667	24	credited	credit	VBN
cord-350836-1enteev7	667	25	and	and	CC
cord-350836-1enteev7	667	26	that	that	IN
cord-350836-1enteev7	667	27	the	the	DT
cord-350836-1enteev7	667	28	original	original	JJ
cord-350836-1enteev7	667	29	publication	publication	NN
cord-350836-1enteev7	667	30	in	in	IN
cord-350836-1enteev7	667	31	this	this	DT
cord-350836-1enteev7	667	32	journal	journal	NN
cord-350836-1enteev7	667	33	is	be	VBZ
cord-350836-1enteev7	667	34	cited	cite	VBN
cord-350836-1enteev7	667	35	,	,	,
cord-350836-1enteev7	667	36	in	in	IN
cord-350836-1enteev7	667	37	accordance	accordance	NN
cord-350836-1enteev7	667	38	with	with	IN
cord-350836-1enteev7	667	39	accepted	accepted	JJ
cord-350836-1enteev7	667	40	academic	academic	JJ
cord-350836-1enteev7	667	41	practice	practice	NN
cord-350836-1enteev7	667	42	.	.	.
cord-350836-1enteev7	668	1	No	no	DT
cord-350836-1enteev7	668	2	use	use	NN
cord-350836-1enteev7	668	3	,	,	,
cord-350836-1enteev7	668	4	distribution	distribution	NN
cord-350836-1enteev7	668	5	or	or	CC
cord-350836-1enteev7	668	6	reproduction	reproduction	NN
cord-350836-1enteev7	668	7	is	be	VBZ
cord-350836-1enteev7	668	8	permitted	permit	VBN
cord-350836-1enteev7	668	9	which	which	WDT
cord-350836-1enteev7	668	10	does	do	VBZ
cord-350836-1enteev7	668	11	not	not	RB
cord-350836-1enteev7	668	12	comply	comply	VB
cord-350836-1enteev7	668	13	with	with	IN
cord-350836-1enteev7	668	14	these	these	DT
cord-350836-1enteev7	668	15	terms	term	NNS
cord-350836-1enteev7	668	16	.	.	.