id	sid	tid	token	lemma	pos
en-wikipedia-org-3485	1	1	Reward	reward	VB
en-wikipedia-org-3485	1	2	system	system	NN
en-wikipedia-org-3485	1	3	-	-	HYPH
en-wikipedia-org-3485	1	4	Wikipedia	Wikipedia	NNP
en-wikipedia-org-3485	1	5	Reward	Reward	NNP
en-wikipedia-org-3485	1	6	system	system	NN
en-wikipedia-org-3485	1	7	From	from	IN
en-wikipedia-org-3485	1	8	Wikipedia	Wikipedia	NNP
en-wikipedia-org-3485	1	9	,	,	,
en-wikipedia-org-3485	1	10	the	the	DT
en-wikipedia-org-3485	1	11	free	free	JJ
en-wikipedia-org-3485	1	12	encyclopedia	encyclopedia	NN
en-wikipedia-org-3485	1	13	  	  	_SP
en-wikipedia-org-3485	1	14	(	(	-LRB-
en-wikipedia-org-3485	1	15	Redirected	redirect	VBN
en-wikipedia-org-3485	1	16	from	from	IN
en-wikipedia-org-3485	1	17	Pleasure	Pleasure	NNP
en-wikipedia-org-3485	1	18	center	center	NN
en-wikipedia-org-3485	1	19	)	)	-RRB-
en-wikipedia-org-3485	1	20	Jump	jump	VB
en-wikipedia-org-3485	1	21	to	to	IN
en-wikipedia-org-3485	1	22	navigation	navigation	NN
en-wikipedia-org-3485	1	23	Jump	Jump	NNP
en-wikipedia-org-3485	1	24	to	to	TO
en-wikipedia-org-3485	1	25	search	search	VB
en-wikipedia-org-3485	1	26	Group	Group	NNP
en-wikipedia-org-3485	1	27	of	of	IN
en-wikipedia-org-3485	1	28	neural	neural	JJ
en-wikipedia-org-3485	1	29	structures	structure	NNS
en-wikipedia-org-3485	1	30	responsible	responsible	JJ
en-wikipedia-org-3485	1	31	for	for	IN
en-wikipedia-org-3485	1	32	motivation	motivation	NN
en-wikipedia-org-3485	1	33	and	and	CC
en-wikipedia-org-3485	1	34	desire	desire	NN
en-wikipedia-org-3485	1	35	The	the	DT
en-wikipedia-org-3485	1	36	reward	reward	NN
en-wikipedia-org-3485	1	37	system	system	NN
en-wikipedia-org-3485	1	38	(	(	-LRB-
en-wikipedia-org-3485	1	39	the	the	DT
en-wikipedia-org-3485	1	40	mesocorticolimbic	mesocorticolimbic	NNP
en-wikipedia-org-3485	1	41	circuit	circuit	NNP
en-wikipedia-org-3485	1	42	)	)	-RRB-
en-wikipedia-org-3485	1	43	is	be	VBZ
en-wikipedia-org-3485	1	44	a	a	DT
en-wikipedia-org-3485	1	45	group	group	NN
en-wikipedia-org-3485	1	46	of	of	IN
en-wikipedia-org-3485	1	47	neural	neural	JJ
en-wikipedia-org-3485	1	48	structures	structure	NNS
en-wikipedia-org-3485	1	49	responsible	responsible	JJ
en-wikipedia-org-3485	1	50	for	for	IN
en-wikipedia-org-3485	1	51	incentive	incentive	NN
en-wikipedia-org-3485	1	52	salience	salience	NN
en-wikipedia-org-3485	1	53	(	(	-LRB-
en-wikipedia-org-3485	1	54	i.e.	i.e.	FW
en-wikipedia-org-3485	1	55	,	,	,
en-wikipedia-org-3485	1	56	motivation	motivation	NN
en-wikipedia-org-3485	1	57	and	and	CC
en-wikipedia-org-3485	1	58	"	"	``
en-wikipedia-org-3485	1	59	wanting	want	VBG
en-wikipedia-org-3485	1	60	"	"	''
en-wikipedia-org-3485	1	61	;	;	:
en-wikipedia-org-3485	1	62	desire	desire	NN
en-wikipedia-org-3485	1	63	or	or	CC
en-wikipedia-org-3485	1	64	craving	crave	VBG
en-wikipedia-org-3485	1	65	for	for	IN
en-wikipedia-org-3485	1	66	a	a	DT
en-wikipedia-org-3485	1	67	reward	reward	NN
en-wikipedia-org-3485	1	68	)	)	-RRB-
en-wikipedia-org-3485	1	69	,	,	,
en-wikipedia-org-3485	1	70	associative	associative	JJ
en-wikipedia-org-3485	1	71	learning	learning	NN
en-wikipedia-org-3485	1	72	(	(	-LRB-
en-wikipedia-org-3485	1	73	primarily	primarily	RB
en-wikipedia-org-3485	1	74	positive	positive	JJ
en-wikipedia-org-3485	1	75	reinforcement	reinforcement	NN
en-wikipedia-org-3485	1	76	and	and	CC
en-wikipedia-org-3485	1	77	classical	classical	JJ
en-wikipedia-org-3485	1	78	conditioning	conditioning	NN
en-wikipedia-org-3485	1	79	)	)	-RRB-
en-wikipedia-org-3485	1	80	,	,	,
en-wikipedia-org-3485	1	81	and	and	CC
en-wikipedia-org-3485	1	82	positively	positively	RB
en-wikipedia-org-3485	1	83	-	-	HYPH
en-wikipedia-org-3485	1	84	valenced	valence	VBN
en-wikipedia-org-3485	1	85	emotions	emotion	NNS
en-wikipedia-org-3485	1	86	,	,	,
en-wikipedia-org-3485	1	87	particularly	particularly	RB
en-wikipedia-org-3485	1	88	ones	one	NNS
en-wikipedia-org-3485	1	89	involving	involve	VBG
en-wikipedia-org-3485	1	90	pleasure	pleasure	NN
en-wikipedia-org-3485	1	91	as	as	IN
en-wikipedia-org-3485	1	92	a	a	DT
en-wikipedia-org-3485	1	93	core	core	NN
en-wikipedia-org-3485	1	94	component	component	NN
en-wikipedia-org-3485	1	95	(	(	-LRB-
en-wikipedia-org-3485	1	96	e.g.	e.g.	RB
en-wikipedia-org-3485	1	97	,	,	,
en-wikipedia-org-3485	1	98	joy	joy	NN
en-wikipedia-org-3485	1	99	,	,	,
en-wikipedia-org-3485	1	100	euphoria	euphoria	NN
en-wikipedia-org-3485	1	101	and	and	CC
en-wikipedia-org-3485	1	102	ecstasy	ecstasy	NN
en-wikipedia-org-3485	1	103	)	)	-RRB-
en-wikipedia-org-3485	1	104	.	.	.
en-wikipedia-org-3485	2	1	[	[	-LRB-
en-wikipedia-org-3485	2	2	1][2	1][2	NNP
en-wikipedia-org-3485	2	3	]	]	-RRB-
en-wikipedia-org-3485	2	4	Reward	Reward	NNP
en-wikipedia-org-3485	2	5	is	be	VBZ
en-wikipedia-org-3485	2	6	the	the	DT
en-wikipedia-org-3485	2	7	attractive	attractive	JJ
en-wikipedia-org-3485	2	8	and	and	CC
en-wikipedia-org-3485	2	9	motivational	motivational	JJ
en-wikipedia-org-3485	2	10	property	property	NN
en-wikipedia-org-3485	2	11	of	of	IN
en-wikipedia-org-3485	2	12	a	a	DT
en-wikipedia-org-3485	2	13	stimulus	stimulus	NN
en-wikipedia-org-3485	2	14	that	that	WDT
en-wikipedia-org-3485	2	15	induces	induce	VBZ
en-wikipedia-org-3485	2	16	appetitive	appetitive	JJ
en-wikipedia-org-3485	2	17	behavior	behavior	NN
en-wikipedia-org-3485	2	18	,	,	,
en-wikipedia-org-3485	2	19	also	also	RB
en-wikipedia-org-3485	2	20	known	know	VBN
en-wikipedia-org-3485	2	21	as	as	IN
en-wikipedia-org-3485	2	22	approach	approach	NN
en-wikipedia-org-3485	2	23	or	or	CC
en-wikipedia-org-3485	2	24	consummatory	consummatory	JJ
en-wikipedia-org-3485	2	25	behavior	behavior	NN
en-wikipedia-org-3485	2	26	.	.	.
en-wikipedia-org-3485	3	1	[	[	-LRB-
en-wikipedia-org-3485	3	2	1	1	LS
en-wikipedia-org-3485	3	3	]	]	-RRB-
en-wikipedia-org-3485	3	4	A	a	DT
en-wikipedia-org-3485	3	5	rewarding	rewarding	JJ
en-wikipedia-org-3485	3	6	stimulus	stimulus	NN
en-wikipedia-org-3485	3	7	(	(	-LRB-
en-wikipedia-org-3485	3	8	i.e.	i.e.	FW
en-wikipedia-org-3485	3	9	,	,	,
en-wikipedia-org-3485	3	10	"	"	''
en-wikipedia-org-3485	3	11	a	a	DT
en-wikipedia-org-3485	3	12	reward	reward	NN
en-wikipedia-org-3485	3	13	"	"	''
en-wikipedia-org-3485	3	14	)	)	-RRB-
en-wikipedia-org-3485	3	15	has	have	VBZ
en-wikipedia-org-3485	3	16	been	be	VBN
en-wikipedia-org-3485	3	17	described	describe	VBN
en-wikipedia-org-3485	3	18	as	as	IN
en-wikipedia-org-3485	3	19	"	"	``
en-wikipedia-org-3485	3	20	any	any	DT
en-wikipedia-org-3485	3	21	stimulus	stimulus	NN
en-wikipedia-org-3485	3	22	,	,	,
en-wikipedia-org-3485	3	23	object	object	NN
en-wikipedia-org-3485	3	24	,	,	,
en-wikipedia-org-3485	3	25	event	event	NN
en-wikipedia-org-3485	3	26	,	,	,
en-wikipedia-org-3485	3	27	activity	activity	NN
en-wikipedia-org-3485	3	28	,	,	,
en-wikipedia-org-3485	3	29	or	or	CC
en-wikipedia-org-3485	3	30	situation	situation	NN
en-wikipedia-org-3485	3	31	that	that	WDT
en-wikipedia-org-3485	3	32	has	have	VBZ
en-wikipedia-org-3485	3	33	the	the	DT
en-wikipedia-org-3485	3	34	potential	potential	NN
en-wikipedia-org-3485	3	35	to	to	TO
en-wikipedia-org-3485	3	36	make	make	VB
en-wikipedia-org-3485	3	37	us	-PRON-	PRP
en-wikipedia-org-3485	3	38	approach	approach	VB
en-wikipedia-org-3485	3	39	and	and	CC
en-wikipedia-org-3485	3	40	consume	consume	VB
en-wikipedia-org-3485	3	41	it	-PRON-	PRP
en-wikipedia-org-3485	3	42	is	be	VBZ
en-wikipedia-org-3485	3	43	by	by	IN
en-wikipedia-org-3485	3	44	definition	definition	NN
en-wikipedia-org-3485	3	45	a	a	DT
en-wikipedia-org-3485	3	46	reward	reward	NN
en-wikipedia-org-3485	3	47	"	"	''
en-wikipedia-org-3485	3	48	.	.	.
en-wikipedia-org-3485	4	1	[	[	-LRB-
en-wikipedia-org-3485	4	2	1	1	LS
en-wikipedia-org-3485	4	3	]	]	-RRB-
en-wikipedia-org-3485	4	4	In	in	IN
en-wikipedia-org-3485	4	5	operant	operant	JJ
en-wikipedia-org-3485	4	6	conditioning	conditioning	NN
en-wikipedia-org-3485	4	7	,	,	,
en-wikipedia-org-3485	4	8	rewarding	rewarding	JJ
en-wikipedia-org-3485	4	9	stimuli	stimulus	NNS
en-wikipedia-org-3485	4	10	function	function	NN
en-wikipedia-org-3485	4	11	as	as	IN
en-wikipedia-org-3485	4	12	positive	positive	JJ
en-wikipedia-org-3485	4	13	reinforcers;[3	reinforcers;[3	NN
en-wikipedia-org-3485	4	14	]	]	-RRB-
en-wikipedia-org-3485	4	15	however	however	RB
en-wikipedia-org-3485	4	16	,	,	,
en-wikipedia-org-3485	4	17	the	the	DT
en-wikipedia-org-3485	4	18	converse	converse	NN
en-wikipedia-org-3485	4	19	statement	statement	NN
en-wikipedia-org-3485	4	20	also	also	RB
en-wikipedia-org-3485	4	21	holds	hold	VBZ
en-wikipedia-org-3485	4	22	true	true	JJ
en-wikipedia-org-3485	4	23	:	:	:
en-wikipedia-org-3485	4	24	positive	positive	JJ
en-wikipedia-org-3485	4	25	reinforcers	reinforcer	NNS
en-wikipedia-org-3485	4	26	are	be	VBP
en-wikipedia-org-3485	4	27	rewarding	rewarding	JJ
en-wikipedia-org-3485	4	28	.	.	.
en-wikipedia-org-3485	5	1	[	[	-LRB-
en-wikipedia-org-3485	5	2	3	3	LS
en-wikipedia-org-3485	5	3	]	]	-RRB-
en-wikipedia-org-3485	5	4	Examples	example	NNS
en-wikipedia-org-3485	5	5	of	of	IN
en-wikipedia-org-3485	5	6	primary	primary	JJ
en-wikipedia-org-3485	5	7	rewards	reward	NNS
en-wikipedia-org-3485	5	8	.	.	.
en-wikipedia-org-3485	6	1	[	[	-LRB-
en-wikipedia-org-3485	6	2	3	3	LS
en-wikipedia-org-3485	6	3	]	]	-RRB-
en-wikipedia-org-3485	6	4	Clockwise	clockwise	NN
en-wikipedia-org-3485	6	5	from	from	IN
en-wikipedia-org-3485	6	6	top	top	JJ
en-wikipedia-org-3485	6	7	:	:	:
en-wikipedia-org-3485	6	8	water	water	NN
en-wikipedia-org-3485	6	9	,	,	,
en-wikipedia-org-3485	6	10	food	food	NN
en-wikipedia-org-3485	6	11	,	,	,
en-wikipedia-org-3485	6	12	parental	parental	JJ
en-wikipedia-org-3485	6	13	care	care	NN
en-wikipedia-org-3485	6	14	and	and	CC
en-wikipedia-org-3485	6	15	sex	sex	NN
en-wikipedia-org-3485	6	16	.	.	.
en-wikipedia-org-3485	7	1	Addiction	addiction	NN
en-wikipedia-org-3485	7	2	and	and	CC
en-wikipedia-org-3485	7	3	dependence	dependence	NN
en-wikipedia-org-3485	7	4	glossary[4][5][6][7	glossary[4][5][6][7	NNS
en-wikipedia-org-3485	7	5	]	]	-RRB-
en-wikipedia-org-3485	7	6	addiction	addiction	NN
en-wikipedia-org-3485	7	7	–	–	:
en-wikipedia-org-3485	7	8	a	a	DT
en-wikipedia-org-3485	7	9	biopsychosocial	biopsychosocial	JJ
en-wikipedia-org-3485	7	10	disorder	disorder	NN
en-wikipedia-org-3485	7	11	characterized	characterize	VBN
en-wikipedia-org-3485	7	12	by	by	IN
en-wikipedia-org-3485	7	13	persistent	persistent	JJ
en-wikipedia-org-3485	7	14	use	use	NN
en-wikipedia-org-3485	7	15	of	of	IN
en-wikipedia-org-3485	7	16	drugs	drug	NNS
en-wikipedia-org-3485	7	17	(	(	-LRB-
en-wikipedia-org-3485	7	18	including	include	VBG
en-wikipedia-org-3485	7	19	alcohol	alcohol	NN
en-wikipedia-org-3485	7	20	)	)	-RRB-
en-wikipedia-org-3485	7	21	despite	despite	IN
en-wikipedia-org-3485	7	22	substantial	substantial	JJ
en-wikipedia-org-3485	7	23	harm	harm	NN
en-wikipedia-org-3485	7	24	and	and	CC
en-wikipedia-org-3485	7	25	adverse	adverse	JJ
en-wikipedia-org-3485	7	26	consequences	consequence	NNS
en-wikipedia-org-3485	7	27	addictive	addictive	JJ
en-wikipedia-org-3485	7	28	behavior	behavior	NN
en-wikipedia-org-3485	7	29	–	–	:
en-wikipedia-org-3485	7	30	a	a	DT
en-wikipedia-org-3485	7	31	behavior	behavior	NN
en-wikipedia-org-3485	7	32	that	that	WDT
en-wikipedia-org-3485	7	33	is	be	VBZ
en-wikipedia-org-3485	7	34	both	both	DT
en-wikipedia-org-3485	7	35	rewarding	rewarding	JJ
en-wikipedia-org-3485	7	36	and	and	CC
en-wikipedia-org-3485	7	37	reinforcing	reinforce	VBG
en-wikipedia-org-3485	7	38	addictive	addictive	JJ
en-wikipedia-org-3485	7	39	drug	drug	NN
en-wikipedia-org-3485	7	40	–	–	:
en-wikipedia-org-3485	7	41	a	a	DT
en-wikipedia-org-3485	7	42	drug	drug	NN
en-wikipedia-org-3485	7	43	that	that	WDT
en-wikipedia-org-3485	7	44	is	be	VBZ
en-wikipedia-org-3485	7	45	both	both	DT
en-wikipedia-org-3485	7	46	rewarding	rewarding	JJ
en-wikipedia-org-3485	7	47	and	and	CC
en-wikipedia-org-3485	7	48	reinforcing	reinforce	VBG
en-wikipedia-org-3485	7	49	dependence	dependence	NN
en-wikipedia-org-3485	7	50	–	–	:
en-wikipedia-org-3485	7	51	an	an	DT
en-wikipedia-org-3485	7	52	adaptive	adaptive	JJ
en-wikipedia-org-3485	7	53	state	state	NN
en-wikipedia-org-3485	7	54	associated	associate	VBN
en-wikipedia-org-3485	7	55	with	with	IN
en-wikipedia-org-3485	7	56	a	a	DT
en-wikipedia-org-3485	7	57	withdrawal	withdrawal	NN
en-wikipedia-org-3485	7	58	syndrome	syndrome	NN
en-wikipedia-org-3485	7	59	upon	upon	IN
en-wikipedia-org-3485	7	60	cessation	cessation	NN
en-wikipedia-org-3485	7	61	of	of	IN
en-wikipedia-org-3485	7	62	repeated	repeat	VBN
en-wikipedia-org-3485	7	63	exposure	exposure	NN
en-wikipedia-org-3485	7	64	to	to	IN
en-wikipedia-org-3485	7	65	a	a	DT
en-wikipedia-org-3485	7	66	stimulus	stimulus	NN
en-wikipedia-org-3485	7	67	(	(	-LRB-
en-wikipedia-org-3485	7	68	e.g.	e.g.	RB
en-wikipedia-org-3485	7	69	,	,	,
en-wikipedia-org-3485	7	70	drug	drug	NN
en-wikipedia-org-3485	7	71	intake	intake	NN
en-wikipedia-org-3485	7	72	)	)	-RRB-
en-wikipedia-org-3485	7	73	drug	drug	NN
en-wikipedia-org-3485	7	74	sensitization	sensitization	NN
en-wikipedia-org-3485	7	75	or	or	CC
en-wikipedia-org-3485	7	76	reverse	reverse	VB
en-wikipedia-org-3485	7	77	tolerance	tolerance	NN
en-wikipedia-org-3485	7	78	–	–	:
en-wikipedia-org-3485	7	79	the	the	DT
en-wikipedia-org-3485	7	80	escalating	escalate	VBG
en-wikipedia-org-3485	7	81	effect	effect	NN
en-wikipedia-org-3485	7	82	of	of	IN
en-wikipedia-org-3485	7	83	a	a	DT
en-wikipedia-org-3485	7	84	drug	drug	NN
en-wikipedia-org-3485	7	85	resulting	result	VBG
en-wikipedia-org-3485	7	86	from	from	IN
en-wikipedia-org-3485	7	87	repeated	repeat	VBN
en-wikipedia-org-3485	7	88	administration	administration	NN
en-wikipedia-org-3485	7	89	at	at	IN
en-wikipedia-org-3485	7	90	a	a	DT
en-wikipedia-org-3485	7	91	given	give	VBN
en-wikipedia-org-3485	7	92	dose	dose	NN
en-wikipedia-org-3485	7	93	drug	drug	NN
en-wikipedia-org-3485	7	94	withdrawal	withdrawal	NN
en-wikipedia-org-3485	7	95	–	–	:
en-wikipedia-org-3485	7	96	symptoms	symptom	NNS
en-wikipedia-org-3485	7	97	that	that	WDT
en-wikipedia-org-3485	7	98	occur	occur	VBP
en-wikipedia-org-3485	7	99	upon	upon	IN
en-wikipedia-org-3485	7	100	cessation	cessation	NN
en-wikipedia-org-3485	7	101	of	of	IN
en-wikipedia-org-3485	7	102	repeated	repeat	VBN
en-wikipedia-org-3485	7	103	drug	drug	NN
en-wikipedia-org-3485	7	104	use	use	NN
en-wikipedia-org-3485	7	105	physical	physical	JJ
en-wikipedia-org-3485	7	106	dependence	dependence	NN
en-wikipedia-org-3485	7	107	–	–	:
en-wikipedia-org-3485	7	108	dependence	dependence	NN
en-wikipedia-org-3485	7	109	that	that	WDT
en-wikipedia-org-3485	7	110	involves	involve	VBZ
en-wikipedia-org-3485	7	111	persistent	persistent	JJ
en-wikipedia-org-3485	7	112	physical	physical	JJ
en-wikipedia-org-3485	7	113	–	–	:
en-wikipedia-org-3485	7	114	somatic	somatic	JJ
en-wikipedia-org-3485	7	115	withdrawal	withdrawal	NN
en-wikipedia-org-3485	7	116	symptoms	symptom	NNS
en-wikipedia-org-3485	7	117	(	(	-LRB-
en-wikipedia-org-3485	7	118	e.g.	e.g.	RB
en-wikipedia-org-3485	7	119	,	,	,
en-wikipedia-org-3485	7	120	fatigue	fatigue	NN
en-wikipedia-org-3485	7	121	and	and	CC
en-wikipedia-org-3485	7	122	delirium	delirium	NN
en-wikipedia-org-3485	7	123	tremens	tremen	NNS
en-wikipedia-org-3485	7	124	)	)	-RRB-
en-wikipedia-org-3485	7	125	psychological	psychological	JJ
en-wikipedia-org-3485	7	126	dependence	dependence	NN
en-wikipedia-org-3485	7	127	–	–	:
en-wikipedia-org-3485	7	128	dependence	dependence	NN
en-wikipedia-org-3485	7	129	that	that	WDT
en-wikipedia-org-3485	7	130	involves	involve	VBZ
en-wikipedia-org-3485	7	131	emotional	emotional	JJ
en-wikipedia-org-3485	7	132	–	–	:
en-wikipedia-org-3485	7	133	motivational	motivational	JJ
en-wikipedia-org-3485	7	134	withdrawal	withdrawal	NN
en-wikipedia-org-3485	7	135	symptoms	symptom	NNS
en-wikipedia-org-3485	7	136	(	(	-LRB-
en-wikipedia-org-3485	7	137	e.g.	e.g.	NNP
en-wikipedia-org-3485	7	138	,	,	,
en-wikipedia-org-3485	7	139	dysphoria	dysphoria	NNP
en-wikipedia-org-3485	7	140	and	and	CC
en-wikipedia-org-3485	7	141	anhedonia	anhedonia	NNP
en-wikipedia-org-3485	7	142	)	)	-RRB-
en-wikipedia-org-3485	7	143	reinforcing	reinforce	VBG
en-wikipedia-org-3485	7	144	stimuli	stimulus	NNS
en-wikipedia-org-3485	7	145	–	–	:
en-wikipedia-org-3485	7	146	stimuli	stimulus	NNS
en-wikipedia-org-3485	7	147	that	that	WDT
en-wikipedia-org-3485	7	148	increase	increase	VBP
en-wikipedia-org-3485	7	149	the	the	DT
en-wikipedia-org-3485	7	150	probability	probability	NN
en-wikipedia-org-3485	7	151	of	of	IN
en-wikipedia-org-3485	7	152	repeating	repeat	VBG
en-wikipedia-org-3485	7	153	behaviors	behavior	NNS
en-wikipedia-org-3485	7	154	paired	pair	VBN
en-wikipedia-org-3485	7	155	with	with	IN
en-wikipedia-org-3485	7	156	them	-PRON-	PRP
en-wikipedia-org-3485	7	157	rewarding	rewarding	JJ
en-wikipedia-org-3485	7	158	stimuli	stimulus	NNS
en-wikipedia-org-3485	7	159	–	–	:
en-wikipedia-org-3485	7	160	stimuli	stimulus	NNS
en-wikipedia-org-3485	7	161	that	that	WDT
en-wikipedia-org-3485	7	162	the	the	DT
en-wikipedia-org-3485	7	163	brain	brain	NN
en-wikipedia-org-3485	7	164	interprets	interpret	VBZ
en-wikipedia-org-3485	7	165	as	as	RB
en-wikipedia-org-3485	7	166	intrinsically	intrinsically	RB
en-wikipedia-org-3485	7	167	positive	positive	JJ
en-wikipedia-org-3485	7	168	and	and	CC
en-wikipedia-org-3485	7	169	desirable	desirable	JJ
en-wikipedia-org-3485	7	170	or	or	CC
en-wikipedia-org-3485	7	171	as	as	IN
en-wikipedia-org-3485	7	172	something	something	NN
en-wikipedia-org-3485	7	173	to	to	TO
en-wikipedia-org-3485	7	174	approach	approach	VB
en-wikipedia-org-3485	7	175	sensitization	sensitization	NN
en-wikipedia-org-3485	7	176	–	–	:
en-wikipedia-org-3485	7	177	an	an	DT
en-wikipedia-org-3485	7	178	amplified	amplified	JJ
en-wikipedia-org-3485	7	179	response	response	NN
en-wikipedia-org-3485	7	180	to	to	IN
en-wikipedia-org-3485	7	181	a	a	DT
en-wikipedia-org-3485	7	182	stimulus	stimulus	NN
en-wikipedia-org-3485	7	183	resulting	result	VBG
en-wikipedia-org-3485	7	184	from	from	IN
en-wikipedia-org-3485	7	185	repeated	repeat	VBN
en-wikipedia-org-3485	7	186	exposure	exposure	NN
en-wikipedia-org-3485	7	187	to	to	IN
en-wikipedia-org-3485	7	188	it	-PRON-	PRP
en-wikipedia-org-3485	7	189	substance	substance	VB
en-wikipedia-org-3485	7	190	use	use	NN
en-wikipedia-org-3485	7	191	disorder	disorder	NN
en-wikipedia-org-3485	7	192	–	–	:
en-wikipedia-org-3485	7	193	a	a	DT
en-wikipedia-org-3485	7	194	condition	condition	NN
en-wikipedia-org-3485	7	195	in	in	IN
en-wikipedia-org-3485	7	196	which	which	WDT
en-wikipedia-org-3485	7	197	the	the	DT
en-wikipedia-org-3485	7	198	use	use	NN
en-wikipedia-org-3485	7	199	of	of	IN
en-wikipedia-org-3485	7	200	substances	substance	NNS
en-wikipedia-org-3485	7	201	leads	lead	VBZ
en-wikipedia-org-3485	7	202	to	to	IN
en-wikipedia-org-3485	7	203	clinically	clinically	RB
en-wikipedia-org-3485	7	204	and	and	CC
en-wikipedia-org-3485	7	205	functionally	functionally	RB
en-wikipedia-org-3485	7	206	significant	significant	JJ
en-wikipedia-org-3485	7	207	impairment	impairment	NN
en-wikipedia-org-3485	7	208	or	or	CC
en-wikipedia-org-3485	7	209	distress	distress	NN
en-wikipedia-org-3485	7	210	tolerance	tolerance	NN
en-wikipedia-org-3485	7	211	–	–	:
en-wikipedia-org-3485	7	212	the	the	DT
en-wikipedia-org-3485	7	213	diminishing	diminish	VBG
en-wikipedia-org-3485	7	214	effect	effect	NN
en-wikipedia-org-3485	7	215	of	of	IN
en-wikipedia-org-3485	7	216	a	a	DT
en-wikipedia-org-3485	7	217	drug	drug	NN
en-wikipedia-org-3485	7	218	resulting	result	VBG
en-wikipedia-org-3485	7	219	from	from	IN
en-wikipedia-org-3485	7	220	repeated	repeat	VBN
en-wikipedia-org-3485	7	221	administration	administration	NN
en-wikipedia-org-3485	7	222	at	at	IN
en-wikipedia-org-3485	7	223	a	a	DT
en-wikipedia-org-3485	7	224	given	give	VBN
en-wikipedia-org-3485	7	225	dose	dose	NN
en-wikipedia-org-3485	7	226	v	v	NNP
en-wikipedia-org-3485	7	227	t	t	NN
en-wikipedia-org-3485	7	228	e	e	NNP
en-wikipedia-org-3485	7	229	The	the	DT
en-wikipedia-org-3485	7	230	reward	reward	NN
en-wikipedia-org-3485	7	231	system	system	NN
en-wikipedia-org-3485	7	232	motivates	motivate	NNS
en-wikipedia-org-3485	7	233	animals	animal	NNS
en-wikipedia-org-3485	7	234	to	to	TO
en-wikipedia-org-3485	7	235	approach	approach	NN
en-wikipedia-org-3485	7	236	stimuli	stimulus	NNS
en-wikipedia-org-3485	7	237	or	or	CC
en-wikipedia-org-3485	7	238	engage	engage	VB
en-wikipedia-org-3485	7	239	in	in	IN
en-wikipedia-org-3485	7	240	behaviour	behaviour	NN
en-wikipedia-org-3485	7	241	that	that	WDT
en-wikipedia-org-3485	7	242	increases	increase	VBZ
en-wikipedia-org-3485	7	243	fitness	fitness	NN
en-wikipedia-org-3485	7	244	(	(	-LRB-
en-wikipedia-org-3485	7	245	sex	sex	NN
en-wikipedia-org-3485	7	246	,	,	,
en-wikipedia-org-3485	7	247	energy	energy	NN
en-wikipedia-org-3485	7	248	dense	dense	JJ
en-wikipedia-org-3485	7	249	foods	food	NNS
en-wikipedia-org-3485	7	250	,	,	,
en-wikipedia-org-3485	7	251	etc	etc	FW
en-wikipedia-org-3485	7	252	.	.	.
en-wikipedia-org-3485	7	253	)	)	-RRB-
en-wikipedia-org-3485	8	1	Survival	survival	NN
en-wikipedia-org-3485	8	2	for	for	IN
en-wikipedia-org-3485	8	3	most	most	JJS
en-wikipedia-org-3485	8	4	animal	animal	NN
en-wikipedia-org-3485	8	5	species	species	NN
en-wikipedia-org-3485	8	6	depends	depend	VBZ
en-wikipedia-org-3485	8	7	upon	upon	IN
en-wikipedia-org-3485	8	8	maximizing	maximize	VBG
en-wikipedia-org-3485	8	9	contact	contact	NN
en-wikipedia-org-3485	8	10	with	with	IN
en-wikipedia-org-3485	8	11	beneficial	beneficial	JJ
en-wikipedia-org-3485	8	12	stimuli	stimulus	NNS
en-wikipedia-org-3485	8	13	and	and	CC
en-wikipedia-org-3485	8	14	minimizing	minimize	VBG
en-wikipedia-org-3485	8	15	contact	contact	NN
en-wikipedia-org-3485	8	16	with	with	IN
en-wikipedia-org-3485	8	17	harmful	harmful	JJ
en-wikipedia-org-3485	8	18	stimuli	stimulus	NNS
en-wikipedia-org-3485	8	19	.	.	.
en-wikipedia-org-3485	9	1	Reward	reward	VB
en-wikipedia-org-3485	9	2	cognition	cognition	NN
en-wikipedia-org-3485	9	3	serves	serve	VBZ
en-wikipedia-org-3485	9	4	to	to	TO
en-wikipedia-org-3485	9	5	increase	increase	VB
en-wikipedia-org-3485	9	6	the	the	DT
en-wikipedia-org-3485	9	7	likelihood	likelihood	NN
en-wikipedia-org-3485	9	8	of	of	IN
en-wikipedia-org-3485	9	9	survival	survival	NN
en-wikipedia-org-3485	9	10	and	and	CC
en-wikipedia-org-3485	9	11	reproduction	reproduction	NN
en-wikipedia-org-3485	9	12	by	by	IN
en-wikipedia-org-3485	9	13	causing	cause	VBG
en-wikipedia-org-3485	9	14	associative	associative	JJ
en-wikipedia-org-3485	9	15	learning	learning	NN
en-wikipedia-org-3485	9	16	,	,	,
en-wikipedia-org-3485	9	17	eliciting	elicit	VBG
en-wikipedia-org-3485	9	18	approach	approach	NN
en-wikipedia-org-3485	9	19	and	and	CC
en-wikipedia-org-3485	9	20	consummatory	consummatory	JJ
en-wikipedia-org-3485	9	21	behavior	behavior	NN
en-wikipedia-org-3485	9	22	,	,	,
en-wikipedia-org-3485	9	23	and	and	CC
en-wikipedia-org-3485	9	24	triggering	trigger	VBG
en-wikipedia-org-3485	9	25	positively	positively	RB
en-wikipedia-org-3485	9	26	-	-	HYPH
en-wikipedia-org-3485	9	27	valenced	valence	VBN
en-wikipedia-org-3485	9	28	emotions	emotion	NNS
en-wikipedia-org-3485	9	29	.	.	.
en-wikipedia-org-3485	10	1	[	[	-LRB-
en-wikipedia-org-3485	10	2	3	3	LS
en-wikipedia-org-3485	10	3	]	]	-RRB-
en-wikipedia-org-3485	10	4	Thus	thus	RB
en-wikipedia-org-3485	10	5	,	,	,
en-wikipedia-org-3485	10	6	reward	reward	NN
en-wikipedia-org-3485	10	7	is	be	VBZ
en-wikipedia-org-3485	10	8	a	a	DT
en-wikipedia-org-3485	10	9	mechanism	mechanism	NN
en-wikipedia-org-3485	10	10	that	that	WDT
en-wikipedia-org-3485	10	11	evolved	evolve	VBD
en-wikipedia-org-3485	10	12	to	to	TO
en-wikipedia-org-3485	10	13	help	help	VB
en-wikipedia-org-3485	10	14	increase	increase	VB
en-wikipedia-org-3485	10	15	the	the	DT
en-wikipedia-org-3485	10	16	adaptive	adaptive	JJ
en-wikipedia-org-3485	10	17	fitness	fitness	NN
en-wikipedia-org-3485	10	18	of	of	IN
en-wikipedia-org-3485	10	19	animals	animal	NNS
en-wikipedia-org-3485	10	20	.	.	.
en-wikipedia-org-3485	11	1	[	[	-LRB-
en-wikipedia-org-3485	11	2	8	8	CD
en-wikipedia-org-3485	11	3	]	]	-RRB-
en-wikipedia-org-3485	11	4	In	in	IN
en-wikipedia-org-3485	11	5	drug	drug	NN
en-wikipedia-org-3485	11	6	addiction	addiction	NN
en-wikipedia-org-3485	11	7	,	,	,
en-wikipedia-org-3485	11	8	certain	certain	JJ
en-wikipedia-org-3485	11	9	substances	substance	NNS
en-wikipedia-org-3485	11	10	over	over	RP
en-wikipedia-org-3485	11	11	-	-	HYPH
en-wikipedia-org-3485	11	12	activate	activate	VB
en-wikipedia-org-3485	11	13	the	the	DT
en-wikipedia-org-3485	11	14	reward	reward	NN
en-wikipedia-org-3485	11	15	circuit	circuit	NN
en-wikipedia-org-3485	11	16	,	,	,
en-wikipedia-org-3485	11	17	leading	lead	VBG
en-wikipedia-org-3485	11	18	to	to	IN
en-wikipedia-org-3485	11	19	compulsive	compulsive	JJ
en-wikipedia-org-3485	11	20	substance	substance	NN
en-wikipedia-org-3485	11	21	-	-	HYPH
en-wikipedia-org-3485	11	22	seeking	seek	VBG
en-wikipedia-org-3485	11	23	behavior	behavior	NN
en-wikipedia-org-3485	11	24	resulting	result	VBG
en-wikipedia-org-3485	11	25	from	from	IN
en-wikipedia-org-3485	11	26	synaptic	synaptic	JJ
en-wikipedia-org-3485	11	27	plasticity	plasticity	NN
en-wikipedia-org-3485	11	28	in	in	IN
en-wikipedia-org-3485	11	29	the	the	DT
en-wikipedia-org-3485	11	30	circuit	circuit	NN
en-wikipedia-org-3485	11	31	.	.	.
en-wikipedia-org-3485	12	1	[	[	-LRB-
en-wikipedia-org-3485	12	2	9	9	CD
en-wikipedia-org-3485	12	3	]	]	-RRB-
en-wikipedia-org-3485	12	4	Primary	primary	JJ
en-wikipedia-org-3485	12	5	rewards	reward	NNS
en-wikipedia-org-3485	12	6	are	be	VBP
en-wikipedia-org-3485	12	7	a	a	DT
en-wikipedia-org-3485	12	8	class	class	NN
en-wikipedia-org-3485	12	9	of	of	IN
en-wikipedia-org-3485	12	10	rewarding	rewarding	JJ
en-wikipedia-org-3485	12	11	stimuli	stimulus	NNS
en-wikipedia-org-3485	12	12	which	which	WDT
en-wikipedia-org-3485	12	13	facilitate	facilitate	VBP
en-wikipedia-org-3485	12	14	the	the	DT
en-wikipedia-org-3485	12	15	survival	survival	NN
en-wikipedia-org-3485	12	16	of	of	IN
en-wikipedia-org-3485	12	17	one	one	NN
en-wikipedia-org-3485	12	18	's	's	POS
en-wikipedia-org-3485	12	19	self	self	NN
en-wikipedia-org-3485	12	20	and	and	CC
en-wikipedia-org-3485	12	21	offspring	offspring	NN
en-wikipedia-org-3485	12	22	,	,	,
en-wikipedia-org-3485	12	23	and	and	CC
en-wikipedia-org-3485	12	24	include	include	VBP
en-wikipedia-org-3485	12	25	homeostatic	homeostatic	JJ
en-wikipedia-org-3485	12	26	(	(	-LRB-
en-wikipedia-org-3485	12	27	e.g.	e.g.	RB
en-wikipedia-org-3485	12	28	,	,	,
en-wikipedia-org-3485	12	29	palatable	palatable	JJ
en-wikipedia-org-3485	12	30	food	food	NN
en-wikipedia-org-3485	12	31	)	)	-RRB-
en-wikipedia-org-3485	12	32	and	and	CC
en-wikipedia-org-3485	12	33	reproductive	reproductive	NNP
en-wikipedia-org-3485	12	34	(	(	-LRB-
en-wikipedia-org-3485	12	35	e.g.	e.g.	RB
en-wikipedia-org-3485	12	36	,	,	,
en-wikipedia-org-3485	12	37	sexual	sexual	JJ
en-wikipedia-org-3485	12	38	contact	contact	NN
en-wikipedia-org-3485	12	39	and	and	CC
en-wikipedia-org-3485	12	40	parental	parental	JJ
en-wikipedia-org-3485	12	41	investment	investment	NN
en-wikipedia-org-3485	12	42	)	)	-RRB-
en-wikipedia-org-3485	12	43	rewards	reward	NNS
en-wikipedia-org-3485	12	44	.	.	.
en-wikipedia-org-3485	13	1	[	[	-LRB-
en-wikipedia-org-3485	13	2	1][10	1][10	LS
en-wikipedia-org-3485	13	3	]	]	-RRB-
en-wikipedia-org-3485	13	4	Intrinsic	intrinsic	JJ
en-wikipedia-org-3485	13	5	rewards	reward	NNS
en-wikipedia-org-3485	13	6	are	be	VBP
en-wikipedia-org-3485	13	7	unconditioned	unconditioned	JJ
en-wikipedia-org-3485	13	8	rewards	reward	NNS
en-wikipedia-org-3485	13	9	that	that	WDT
en-wikipedia-org-3485	13	10	are	be	VBP
en-wikipedia-org-3485	13	11	attractive	attractive	JJ
en-wikipedia-org-3485	13	12	and	and	CC
en-wikipedia-org-3485	13	13	motivate	motivate	JJ
en-wikipedia-org-3485	13	14	behavior	behavior	NN
en-wikipedia-org-3485	13	15	because	because	IN
en-wikipedia-org-3485	13	16	they	-PRON-	PRP
en-wikipedia-org-3485	13	17	are	be	VBP
en-wikipedia-org-3485	13	18	inherently	inherently	RB
en-wikipedia-org-3485	13	19	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	13	20	.	.	.
en-wikipedia-org-3485	14	1	[	[	-LRB-
en-wikipedia-org-3485	14	2	1	1	LS
en-wikipedia-org-3485	14	3	]	]	-RRB-
en-wikipedia-org-3485	14	4	Extrinsic	Extrinsic	NNP
en-wikipedia-org-3485	14	5	rewards	reward	NNS
en-wikipedia-org-3485	14	6	(	(	-LRB-
en-wikipedia-org-3485	14	7	e.g.	e.g.	RB
en-wikipedia-org-3485	14	8	,	,	,
en-wikipedia-org-3485	14	9	money	money	NN
en-wikipedia-org-3485	14	10	or	or	CC
en-wikipedia-org-3485	14	11	seeing	see	VBG
en-wikipedia-org-3485	14	12	one	one	PRP
en-wikipedia-org-3485	14	13	's	's	POS
en-wikipedia-org-3485	14	14	favorite	favorite	JJ
en-wikipedia-org-3485	14	15	sports	sport	NNS
en-wikipedia-org-3485	14	16	team	team	NN
en-wikipedia-org-3485	14	17	winning	win	VBG
en-wikipedia-org-3485	14	18	a	a	DT
en-wikipedia-org-3485	14	19	game	game	NN
en-wikipedia-org-3485	14	20	)	)	-RRB-
en-wikipedia-org-3485	14	21	are	be	VBP
en-wikipedia-org-3485	14	22	conditioned	condition	VBN
en-wikipedia-org-3485	14	23	rewards	reward	NNS
en-wikipedia-org-3485	14	24	that	that	WDT
en-wikipedia-org-3485	14	25	are	be	VBP
en-wikipedia-org-3485	14	26	attractive	attractive	JJ
en-wikipedia-org-3485	14	27	and	and	CC
en-wikipedia-org-3485	14	28	motivate	motivate	JJ
en-wikipedia-org-3485	14	29	behavior	behavior	NN
en-wikipedia-org-3485	14	30	,	,	,
en-wikipedia-org-3485	14	31	but	but	CC
en-wikipedia-org-3485	14	32	are	be	VBP
en-wikipedia-org-3485	14	33	not	not	RB
en-wikipedia-org-3485	14	34	inherently	inherently	RB
en-wikipedia-org-3485	14	35	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	14	36	.	.	.
en-wikipedia-org-3485	15	1	[	[	-LRB-
en-wikipedia-org-3485	15	2	1][11	1][11	LS
en-wikipedia-org-3485	15	3	]	]	-RRB-
en-wikipedia-org-3485	15	4	Extrinsic	Extrinsic	NNP
en-wikipedia-org-3485	15	5	rewards	reward	NNS
en-wikipedia-org-3485	15	6	derive	derive	VBP
en-wikipedia-org-3485	15	7	their	-PRON-	PRP$
en-wikipedia-org-3485	15	8	motivational	motivational	JJ
en-wikipedia-org-3485	15	9	value	value	NN
en-wikipedia-org-3485	15	10	as	as	IN
en-wikipedia-org-3485	15	11	a	a	DT
en-wikipedia-org-3485	15	12	result	result	NN
en-wikipedia-org-3485	15	13	of	of	IN
en-wikipedia-org-3485	15	14	a	a	DT
en-wikipedia-org-3485	15	15	learned	learn	VBN
en-wikipedia-org-3485	15	16	association	association	NN
en-wikipedia-org-3485	15	17	(	(	-LRB-
en-wikipedia-org-3485	15	18	i.e.	i.e.	FW
en-wikipedia-org-3485	15	19	,	,	,
en-wikipedia-org-3485	15	20	conditioning	condition	VBG
en-wikipedia-org-3485	15	21	)	)	-RRB-
en-wikipedia-org-3485	15	22	with	with	IN
en-wikipedia-org-3485	15	23	intrinsic	intrinsic	JJ
en-wikipedia-org-3485	15	24	rewards	reward	NNS
en-wikipedia-org-3485	15	25	.	.	.
en-wikipedia-org-3485	16	1	[	[	-LRB-
en-wikipedia-org-3485	16	2	1	1	LS
en-wikipedia-org-3485	16	3	]	]	-RRB-
en-wikipedia-org-3485	16	4	Extrinsic	Extrinsic	NNP
en-wikipedia-org-3485	16	5	rewards	reward	NNS
en-wikipedia-org-3485	16	6	may	may	MD
en-wikipedia-org-3485	16	7	also	also	RB
en-wikipedia-org-3485	16	8	elicit	elicit	VB
en-wikipedia-org-3485	16	9	pleasure	pleasure	NN
en-wikipedia-org-3485	16	10	(	(	-LRB-
en-wikipedia-org-3485	16	11	e.g.	e.g.	RB
en-wikipedia-org-3485	16	12	,	,	,
en-wikipedia-org-3485	16	13	euphoria	euphoria	NN
en-wikipedia-org-3485	16	14	from	from	IN
en-wikipedia-org-3485	16	15	winning	win	VBG
en-wikipedia-org-3485	16	16	a	a	DT
en-wikipedia-org-3485	16	17	lot	lot	NN
en-wikipedia-org-3485	16	18	of	of	IN
en-wikipedia-org-3485	16	19	money	money	NN
en-wikipedia-org-3485	16	20	in	in	IN
en-wikipedia-org-3485	16	21	a	a	DT
en-wikipedia-org-3485	16	22	lottery	lottery	NN
en-wikipedia-org-3485	16	23	)	)	-RRB-
en-wikipedia-org-3485	16	24	after	after	IN
en-wikipedia-org-3485	16	25	being	be	VBG
en-wikipedia-org-3485	16	26	classically	classically	RB
en-wikipedia-org-3485	16	27	conditioned	condition	VBN
en-wikipedia-org-3485	16	28	with	with	IN
en-wikipedia-org-3485	16	29	intrinsic	intrinsic	JJ
en-wikipedia-org-3485	16	30	rewards	reward	NNS
en-wikipedia-org-3485	16	31	.	.	.
en-wikipedia-org-3485	17	1	[	[	-LRB-
en-wikipedia-org-3485	17	2	1	1	LS
en-wikipedia-org-3485	17	3	]	]	-RRB-
en-wikipedia-org-3485	17	4	Contents	Contents	NNP
en-wikipedia-org-3485	17	5	1	1	CD
en-wikipedia-org-3485	17	6	Definition	definition	NN
en-wikipedia-org-3485	17	7	2	2	CD
en-wikipedia-org-3485	17	8	Neuroanatomy	Neuroanatomy	NNP
en-wikipedia-org-3485	17	9	2.1	2.1	CD
en-wikipedia-org-3485	17	10	Overview	Overview	NNP
en-wikipedia-org-3485	17	11	2.2	2.2	CD
en-wikipedia-org-3485	17	12	Key	Key	NNP
en-wikipedia-org-3485	17	13	Pathway	Pathway	NNP
en-wikipedia-org-3485	17	14	2.3	2.3	CD
en-wikipedia-org-3485	17	15	Pleasure	pleasure	NN
en-wikipedia-org-3485	17	16	centers	center	VBZ
en-wikipedia-org-3485	17	17	3	3	CD
en-wikipedia-org-3485	17	18	Wanting	want	VBG
en-wikipedia-org-3485	17	19	and	and	CC
en-wikipedia-org-3485	17	20	liking	like	VBG
en-wikipedia-org-3485	17	21	4	4	CD
en-wikipedia-org-3485	17	22	Anti	Anti	NNP
en-wikipedia-org-3485	17	23	-	-	HYPH
en-wikipedia-org-3485	17	24	Reward	Reward	NNP
en-wikipedia-org-3485	17	25	system	system	NN
en-wikipedia-org-3485	17	26	5	5	CD
en-wikipedia-org-3485	17	27	Learning	learn	VBG
en-wikipedia-org-3485	17	28	6	6	CD
en-wikipedia-org-3485	17	29	Disorders	Disorders	NNPS
en-wikipedia-org-3485	17	30	6.1	6.1	CD
en-wikipedia-org-3485	17	31	Addiction	addiction	NN
en-wikipedia-org-3485	17	32	6.2	6.2	CD
en-wikipedia-org-3485	17	33	Motivation	Motivation	NNP
en-wikipedia-org-3485	17	34	6.2.1	6.2.1	NNP
en-wikipedia-org-3485	17	35	Mood	Mood	NNP
en-wikipedia-org-3485	17	36	disorders	disorder	VBZ
en-wikipedia-org-3485	17	37	6.2.2	6.2.2	NNP
en-wikipedia-org-3485	17	38	Schizophrenia	Schizophrenia	NNP
en-wikipedia-org-3485	17	39	7	7	CD
en-wikipedia-org-3485	17	40	History	history	NN
en-wikipedia-org-3485	17	41	8	8	CD
en-wikipedia-org-3485	17	42	Other	other	JJ
en-wikipedia-org-3485	17	43	species	specie	NNS
en-wikipedia-org-3485	17	44	9	9	CD
en-wikipedia-org-3485	17	45	See	see	VBP
en-wikipedia-org-3485	17	46	also	also	RB
en-wikipedia-org-3485	17	47	10	10	CD
en-wikipedia-org-3485	17	48	References	reference	NNS
en-wikipedia-org-3485	17	49	11	11	CD
en-wikipedia-org-3485	17	50	External	external	JJ
en-wikipedia-org-3485	17	51	links	link	NNS
en-wikipedia-org-3485	17	52	Definition[edit	definition[edit	VBP
en-wikipedia-org-3485	17	53	]	]	-RRB-
en-wikipedia-org-3485	17	54	In	in	IN
en-wikipedia-org-3485	17	55	neuroscience	neuroscience	NN
en-wikipedia-org-3485	17	56	,	,	,
en-wikipedia-org-3485	17	57	the	the	DT
en-wikipedia-org-3485	17	58	reward	reward	NN
en-wikipedia-org-3485	17	59	system	system	NN
en-wikipedia-org-3485	17	60	is	be	VBZ
en-wikipedia-org-3485	17	61	a	a	DT
en-wikipedia-org-3485	17	62	collection	collection	NN
en-wikipedia-org-3485	17	63	of	of	IN
en-wikipedia-org-3485	17	64	brain	brain	NN
en-wikipedia-org-3485	17	65	structures	structure	NNS
en-wikipedia-org-3485	17	66	and	and	CC
en-wikipedia-org-3485	17	67	neural	neural	JJ
en-wikipedia-org-3485	17	68	pathways	pathway	NNS
en-wikipedia-org-3485	17	69	that	that	WDT
en-wikipedia-org-3485	17	70	are	be	VBP
en-wikipedia-org-3485	17	71	responsible	responsible	JJ
en-wikipedia-org-3485	17	72	for	for	IN
en-wikipedia-org-3485	17	73	reward	reward	VB
en-wikipedia-org-3485	17	74	-	-	HYPH
en-wikipedia-org-3485	17	75	related	relate	VBN
en-wikipedia-org-3485	17	76	cognition	cognition	NN
en-wikipedia-org-3485	17	77	,	,	,
en-wikipedia-org-3485	17	78	including	include	VBG
en-wikipedia-org-3485	17	79	associative	associative	JJ
en-wikipedia-org-3485	17	80	learning	learning	NN
en-wikipedia-org-3485	17	81	(	(	-LRB-
en-wikipedia-org-3485	17	82	primarily	primarily	RB
en-wikipedia-org-3485	17	83	classical	classical	JJ
en-wikipedia-org-3485	17	84	conditioning	conditioning	NN
en-wikipedia-org-3485	17	85	and	and	CC
en-wikipedia-org-3485	17	86	operant	operant	JJ
en-wikipedia-org-3485	17	87	reinforcement	reinforcement	NN
en-wikipedia-org-3485	17	88	)	)	-RRB-
en-wikipedia-org-3485	17	89	,	,	,
en-wikipedia-org-3485	17	90	incentive	incentive	NN
en-wikipedia-org-3485	17	91	salience	salience	NN
en-wikipedia-org-3485	17	92	(	(	-LRB-
en-wikipedia-org-3485	17	93	i.e.	i.e.	FW
en-wikipedia-org-3485	17	94	,	,	,
en-wikipedia-org-3485	17	95	motivation	motivation	NN
en-wikipedia-org-3485	17	96	and	and	CC
en-wikipedia-org-3485	17	97	"	"	``
en-wikipedia-org-3485	17	98	wanting	want	VBG
en-wikipedia-org-3485	17	99	"	"	''
en-wikipedia-org-3485	17	100	,	,	,
en-wikipedia-org-3485	17	101	desire	desire	NN
en-wikipedia-org-3485	17	102	,	,	,
en-wikipedia-org-3485	17	103	or	or	CC
en-wikipedia-org-3485	17	104	craving	crave	VBG
en-wikipedia-org-3485	17	105	for	for	IN
en-wikipedia-org-3485	17	106	a	a	DT
en-wikipedia-org-3485	17	107	reward	reward	NN
en-wikipedia-org-3485	17	108	)	)	-RRB-
en-wikipedia-org-3485	17	109	,	,	,
en-wikipedia-org-3485	17	110	and	and	CC
en-wikipedia-org-3485	17	111	positively	positively	RB
en-wikipedia-org-3485	17	112	-	-	HYPH
en-wikipedia-org-3485	17	113	valenced	valence	VBN
en-wikipedia-org-3485	17	114	emotions	emotion	NNS
en-wikipedia-org-3485	17	115	,	,	,
en-wikipedia-org-3485	17	116	particularly	particularly	RB
en-wikipedia-org-3485	17	117	emotions	emotion	NNS
en-wikipedia-org-3485	17	118	that	that	WDT
en-wikipedia-org-3485	17	119	involve	involve	VBP
en-wikipedia-org-3485	17	120	pleasure	pleasure	NN
en-wikipedia-org-3485	17	121	(	(	-LRB-
en-wikipedia-org-3485	17	122	i.e.	i.e.	FW
en-wikipedia-org-3485	17	123	,	,	,
en-wikipedia-org-3485	17	124	hedonic	hedonic	JJ
en-wikipedia-org-3485	17	125	"	"	''
en-wikipedia-org-3485	17	126	liking	like	VBG
en-wikipedia-org-3485	17	127	"	"	''
en-wikipedia-org-3485	17	128	)	)	-RRB-
en-wikipedia-org-3485	17	129	.	.	.
en-wikipedia-org-3485	18	1	[	[	-LRB-
en-wikipedia-org-3485	18	2	3][2	3][2	NN
en-wikipedia-org-3485	18	3	]	]	-RRB-
en-wikipedia-org-3485	18	4	Terms	term	NNS
en-wikipedia-org-3485	18	5	that	that	WDT
en-wikipedia-org-3485	18	6	are	be	VBP
en-wikipedia-org-3485	18	7	commonly	commonly	RB
en-wikipedia-org-3485	18	8	used	use	VBN
en-wikipedia-org-3485	18	9	to	to	TO
en-wikipedia-org-3485	18	10	describe	describe	VB
en-wikipedia-org-3485	18	11	behavior	behavior	NN
en-wikipedia-org-3485	18	12	related	relate	VBN
en-wikipedia-org-3485	18	13	to	to	IN
en-wikipedia-org-3485	18	14	the	the	DT
en-wikipedia-org-3485	18	15	"	"	``
en-wikipedia-org-3485	18	16	wanting	want	VBG
en-wikipedia-org-3485	18	17	"	"	''
en-wikipedia-org-3485	18	18	or	or	CC
en-wikipedia-org-3485	18	19	desire	desire	NN
en-wikipedia-org-3485	18	20	component	component	NN
en-wikipedia-org-3485	18	21	of	of	IN
en-wikipedia-org-3485	18	22	reward	reward	NN
en-wikipedia-org-3485	18	23	include	include	VBP
en-wikipedia-org-3485	18	24	appetitive	appetitive	JJ
en-wikipedia-org-3485	18	25	behavior	behavior	NN
en-wikipedia-org-3485	18	26	,	,	,
en-wikipedia-org-3485	18	27	approach	approach	NN
en-wikipedia-org-3485	18	28	behavior	behavior	NN
en-wikipedia-org-3485	18	29	,	,	,
en-wikipedia-org-3485	18	30	preparatory	preparatory	JJ
en-wikipedia-org-3485	18	31	behavior	behavior	NN
en-wikipedia-org-3485	18	32	,	,	,
en-wikipedia-org-3485	18	33	instrumental	instrumental	JJ
en-wikipedia-org-3485	18	34	behavior	behavior	NN
en-wikipedia-org-3485	18	35	,	,	,
en-wikipedia-org-3485	18	36	anticipatory	anticipatory	JJ
en-wikipedia-org-3485	18	37	behavior	behavior	NN
en-wikipedia-org-3485	18	38	,	,	,
en-wikipedia-org-3485	18	39	and	and	CC
en-wikipedia-org-3485	18	40	seeking	seek	VBG
en-wikipedia-org-3485	18	41	.	.	.
en-wikipedia-org-3485	19	1	[	[	-LRB-
en-wikipedia-org-3485	19	2	12	12	CD
en-wikipedia-org-3485	19	3	]	]	-RRB-
en-wikipedia-org-3485	19	4	Terms	term	NNS
en-wikipedia-org-3485	19	5	that	that	WDT
en-wikipedia-org-3485	19	6	are	be	VBP
en-wikipedia-org-3485	19	7	commonly	commonly	RB
en-wikipedia-org-3485	19	8	used	use	VBN
en-wikipedia-org-3485	19	9	to	to	TO
en-wikipedia-org-3485	19	10	describe	describe	VB
en-wikipedia-org-3485	19	11	behavior	behavior	NN
en-wikipedia-org-3485	19	12	related	relate	VBN
en-wikipedia-org-3485	19	13	to	to	IN
en-wikipedia-org-3485	19	14	the	the	DT
en-wikipedia-org-3485	19	15	"	"	``
en-wikipedia-org-3485	19	16	liking	like	VBG
en-wikipedia-org-3485	19	17	"	"	''
en-wikipedia-org-3485	19	18	or	or	CC
en-wikipedia-org-3485	19	19	pleasure	pleasure	VB
en-wikipedia-org-3485	19	20	component	component	NN
en-wikipedia-org-3485	19	21	of	of	IN
en-wikipedia-org-3485	19	22	reward	reward	NN
en-wikipedia-org-3485	19	23	include	include	VBP
en-wikipedia-org-3485	19	24	consummatory	consummatory	JJ
en-wikipedia-org-3485	19	25	behavior	behavior	NN
en-wikipedia-org-3485	19	26	and	and	CC
en-wikipedia-org-3485	19	27	taking	take	VBG
en-wikipedia-org-3485	19	28	behavior	behavior	NN
en-wikipedia-org-3485	19	29	.	.	.
en-wikipedia-org-3485	20	1	[	[	-LRB-
en-wikipedia-org-3485	20	2	12	12	CD
en-wikipedia-org-3485	20	3	]	]	-RRB-
en-wikipedia-org-3485	20	4	The	the	DT
en-wikipedia-org-3485	20	5	three	three	CD
en-wikipedia-org-3485	20	6	primary	primary	JJ
en-wikipedia-org-3485	20	7	functions	function	NNS
en-wikipedia-org-3485	20	8	of	of	IN
en-wikipedia-org-3485	20	9	rewards	reward	NNS
en-wikipedia-org-3485	20	10	are	be	VBP
en-wikipedia-org-3485	20	11	their	-PRON-	PRP$
en-wikipedia-org-3485	20	12	capacity	capacity	NN
en-wikipedia-org-3485	20	13	to	to	TO
en-wikipedia-org-3485	20	14	:	:	:
en-wikipedia-org-3485	20	15	produce	produce	VB
en-wikipedia-org-3485	20	16	associative	associative	JJ
en-wikipedia-org-3485	20	17	learning	learning	NN
en-wikipedia-org-3485	20	18	(	(	-LRB-
en-wikipedia-org-3485	20	19	i.e.	i.e.	FW
en-wikipedia-org-3485	20	20	,	,	,
en-wikipedia-org-3485	20	21	classical	classical	JJ
en-wikipedia-org-3485	20	22	conditioning	conditioning	NN
en-wikipedia-org-3485	20	23	and	and	CC
en-wikipedia-org-3485	20	24	operant	operant	JJ
en-wikipedia-org-3485	20	25	reinforcement);[3	reinforcement);[3	NNP
en-wikipedia-org-3485	20	26	]	]	-RRB-
en-wikipedia-org-3485	20	27	affect	affect	VB
en-wikipedia-org-3485	20	28	decision	decision	NN
en-wikipedia-org-3485	20	29	-	-	HYPH
en-wikipedia-org-3485	20	30	making	making	NN
en-wikipedia-org-3485	20	31	and	and	CC
en-wikipedia-org-3485	20	32	induce	induce	VB
en-wikipedia-org-3485	20	33	approach	approach	NN
en-wikipedia-org-3485	20	34	behavior	behavior	NN
en-wikipedia-org-3485	20	35	(	(	-LRB-
en-wikipedia-org-3485	20	36	via	via	IN
en-wikipedia-org-3485	20	37	the	the	DT
en-wikipedia-org-3485	20	38	assignment	assignment	NN
en-wikipedia-org-3485	20	39	of	of	IN
en-wikipedia-org-3485	20	40	motivational	motivational	JJ
en-wikipedia-org-3485	20	41	salience	salience	NN
en-wikipedia-org-3485	20	42	to	to	IN
en-wikipedia-org-3485	20	43	rewarding	rewarding	JJ
en-wikipedia-org-3485	20	44	stimuli);[3	stimuli);[3	NNP
en-wikipedia-org-3485	20	45	]	]	-RRB-
en-wikipedia-org-3485	20	46	elicit	elicit	NN
en-wikipedia-org-3485	20	47	positively	positively	RB
en-wikipedia-org-3485	20	48	-	-	HYPH
en-wikipedia-org-3485	20	49	valenced	valence	VBN
en-wikipedia-org-3485	20	50	emotions	emotion	NNS
en-wikipedia-org-3485	20	51	,	,	,
en-wikipedia-org-3485	20	52	particularly	particularly	RB
en-wikipedia-org-3485	20	53	pleasure	pleasure	NN
en-wikipedia-org-3485	20	54	.	.	.
en-wikipedia-org-3485	21	1	[	[	-LRB-
en-wikipedia-org-3485	21	2	3	3	CD
en-wikipedia-org-3485	21	3	]	]	-RRB-
en-wikipedia-org-3485	21	4	Neuroanatomy[edit	neuroanatomy[edit	NN
en-wikipedia-org-3485	21	5	]	]	-RRB-
en-wikipedia-org-3485	21	6	Overview[edit	overview[edit	LS
en-wikipedia-org-3485	21	7	]	]	-RRB-
en-wikipedia-org-3485	21	8	The	the	DT
en-wikipedia-org-3485	21	9	brain	brain	NN
en-wikipedia-org-3485	21	10	structures	structure	NNS
en-wikipedia-org-3485	21	11	that	that	WDT
en-wikipedia-org-3485	21	12	compose	compose	VBP
en-wikipedia-org-3485	21	13	the	the	DT
en-wikipedia-org-3485	21	14	reward	reward	NN
en-wikipedia-org-3485	21	15	system	system	NN
en-wikipedia-org-3485	21	16	are	be	VBP
en-wikipedia-org-3485	21	17	located	locate	VBN
en-wikipedia-org-3485	21	18	primarily	primarily	RB
en-wikipedia-org-3485	21	19	within	within	IN
en-wikipedia-org-3485	21	20	the	the	DT
en-wikipedia-org-3485	21	21	cortico	cortico	NNP
en-wikipedia-org-3485	21	22	-	-	HYPH
en-wikipedia-org-3485	21	23	basal	basal	NNP
en-wikipedia-org-3485	21	24	ganglia	ganglia	NN
en-wikipedia-org-3485	21	25	-	-	HYPH
en-wikipedia-org-3485	21	26	thalamo	thalamo	NNP
en-wikipedia-org-3485	21	27	-	-	HYPH
en-wikipedia-org-3485	21	28	cortical	cortical	JJ
en-wikipedia-org-3485	21	29	loop;[13	loop;[13	NNS
en-wikipedia-org-3485	21	30	]	]	-RRB-
en-wikipedia-org-3485	21	31	the	the	DT
en-wikipedia-org-3485	21	32	basal	basal	NNP
en-wikipedia-org-3485	21	33	ganglia	ganglia	NNP
en-wikipedia-org-3485	21	34	portion	portion	NNP
en-wikipedia-org-3485	21	35	of	of	IN
en-wikipedia-org-3485	21	36	the	the	DT
en-wikipedia-org-3485	21	37	loop	loop	NN
en-wikipedia-org-3485	21	38	drives	drive	VBZ
en-wikipedia-org-3485	21	39	activity	activity	NN
en-wikipedia-org-3485	21	40	within	within	IN
en-wikipedia-org-3485	21	41	the	the	DT
en-wikipedia-org-3485	21	42	reward	reward	NN
en-wikipedia-org-3485	21	43	system	system	NN
en-wikipedia-org-3485	21	44	.	.	.
en-wikipedia-org-3485	22	1	[	[	-LRB-
en-wikipedia-org-3485	22	2	13	13	CD
en-wikipedia-org-3485	22	3	]	]	-RRB-
en-wikipedia-org-3485	22	4	Most	Most	JJS
en-wikipedia-org-3485	22	5	of	of	IN
en-wikipedia-org-3485	22	6	the	the	DT
en-wikipedia-org-3485	22	7	pathways	pathway	NNS
en-wikipedia-org-3485	22	8	that	that	WDT
en-wikipedia-org-3485	22	9	connect	connect	VBP
en-wikipedia-org-3485	22	10	structures	structure	NNS
en-wikipedia-org-3485	22	11	within	within	IN
en-wikipedia-org-3485	22	12	the	the	DT
en-wikipedia-org-3485	22	13	reward	reward	NN
en-wikipedia-org-3485	22	14	system	system	NN
en-wikipedia-org-3485	22	15	are	be	VBP
en-wikipedia-org-3485	22	16	glutamatergic	glutamatergic	JJ
en-wikipedia-org-3485	22	17	interneurons	interneuron	NNS
en-wikipedia-org-3485	22	18	,	,	,
en-wikipedia-org-3485	22	19	GABAergic	gabaergic	JJ
en-wikipedia-org-3485	22	20	medium	medium	NN
en-wikipedia-org-3485	22	21	spiny	spiny	JJ
en-wikipedia-org-3485	22	22	neurons	neuron	NNS
en-wikipedia-org-3485	22	23	(	(	-LRB-
en-wikipedia-org-3485	22	24	MSNs	MSNs	NNPS
en-wikipedia-org-3485	22	25	)	)	-RRB-
en-wikipedia-org-3485	22	26	,	,	,
en-wikipedia-org-3485	22	27	and	and	CC
en-wikipedia-org-3485	22	28	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	22	29	projection	projection	NN
en-wikipedia-org-3485	22	30	neurons,[13][14	neurons,[13][14	NN
en-wikipedia-org-3485	22	31	]	]	-RRB-
en-wikipedia-org-3485	22	32	although	although	IN
en-wikipedia-org-3485	22	33	other	other	JJ
en-wikipedia-org-3485	22	34	types	type	NNS
en-wikipedia-org-3485	22	35	of	of	IN
en-wikipedia-org-3485	22	36	projection	projection	NN
en-wikipedia-org-3485	22	37	neurons	neuron	NNS
en-wikipedia-org-3485	22	38	contribute	contribute	VBP
en-wikipedia-org-3485	22	39	(	(	-LRB-
en-wikipedia-org-3485	22	40	e.g.	e.g.	RB
en-wikipedia-org-3485	22	41	,	,	,
en-wikipedia-org-3485	22	42	orexinergic	orexinergic	JJ
en-wikipedia-org-3485	22	43	projection	projection	NN
en-wikipedia-org-3485	22	44	neurons	neuron	NNS
en-wikipedia-org-3485	22	45	)	)	-RRB-
en-wikipedia-org-3485	22	46	.	.	.
en-wikipedia-org-3485	23	1	The	the	DT
en-wikipedia-org-3485	23	2	reward	reward	NN
en-wikipedia-org-3485	23	3	system	system	NN
en-wikipedia-org-3485	23	4	includes	include	VBZ
en-wikipedia-org-3485	23	5	the	the	DT
en-wikipedia-org-3485	23	6	ventral	ventral	JJ
en-wikipedia-org-3485	23	7	tegmental	tegmental	JJ
en-wikipedia-org-3485	23	8	area	area	NN
en-wikipedia-org-3485	23	9	,	,	,
en-wikipedia-org-3485	23	10	ventral	ventral	JJ
en-wikipedia-org-3485	23	11	striatum	striatum	NN
en-wikipedia-org-3485	23	12	(	(	-LRB-
en-wikipedia-org-3485	23	13	i.e.	i.e.	FW
en-wikipedia-org-3485	23	14	,	,	,
en-wikipedia-org-3485	23	15	the	the	DT
en-wikipedia-org-3485	23	16	nucleus	nucleus	NN
en-wikipedia-org-3485	23	17	accumbens	accumben	VBZ
en-wikipedia-org-3485	23	18	and	and	CC
en-wikipedia-org-3485	23	19	olfactory	olfactory	JJ
en-wikipedia-org-3485	23	20	tubercle	tubercle	NN
en-wikipedia-org-3485	23	21	)	)	-RRB-
en-wikipedia-org-3485	23	22	,	,	,
en-wikipedia-org-3485	23	23	dorsal	dorsal	NN
en-wikipedia-org-3485	23	24	striatum	striatum	NN
en-wikipedia-org-3485	23	25	(	(	-LRB-
en-wikipedia-org-3485	23	26	i.e.	i.e.	FW
en-wikipedia-org-3485	23	27	,	,	,
en-wikipedia-org-3485	23	28	the	the	DT
en-wikipedia-org-3485	23	29	caudate	caudate	JJ
en-wikipedia-org-3485	23	30	nucleus	nucleus	NN
en-wikipedia-org-3485	23	31	and	and	CC
en-wikipedia-org-3485	23	32	putamen	putamen	NN
en-wikipedia-org-3485	23	33	)	)	-RRB-
en-wikipedia-org-3485	23	34	,	,	,
en-wikipedia-org-3485	23	35	substantia	substantia	NNP
en-wikipedia-org-3485	23	36	nigra	nigra	NNP
en-wikipedia-org-3485	23	37	(	(	-LRB-
en-wikipedia-org-3485	23	38	i.e.	i.e.	FW
en-wikipedia-org-3485	23	39	,	,	,
en-wikipedia-org-3485	23	40	the	the	DT
en-wikipedia-org-3485	23	41	pars	par	NNS
en-wikipedia-org-3485	23	42	compacta	compacta	NN
en-wikipedia-org-3485	23	43	and	and	CC
en-wikipedia-org-3485	23	44	pars	par	NNS
en-wikipedia-org-3485	23	45	reticulata	reticulata	NNP
en-wikipedia-org-3485	23	46	)	)	-RRB-
en-wikipedia-org-3485	23	47	,	,	,
en-wikipedia-org-3485	23	48	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	23	49	cortex	cortex	NNP
en-wikipedia-org-3485	23	50	,	,	,
en-wikipedia-org-3485	23	51	anterior	anterior	NNP
en-wikipedia-org-3485	23	52	cingulate	cingulate	NNP
en-wikipedia-org-3485	23	53	cortex	cortex	NNP
en-wikipedia-org-3485	23	54	,	,	,
en-wikipedia-org-3485	23	55	insular	insular	NNP
en-wikipedia-org-3485	23	56	cortex	cortex	NNP
en-wikipedia-org-3485	23	57	,	,	,
en-wikipedia-org-3485	23	58	hippocampus	hippocampus	NNP
en-wikipedia-org-3485	23	59	,	,	,
en-wikipedia-org-3485	23	60	hypothalamus	hypothalamus	NNP
en-wikipedia-org-3485	23	61	(	(	-LRB-
en-wikipedia-org-3485	23	62	particularly	particularly	RB
en-wikipedia-org-3485	23	63	,	,	,
en-wikipedia-org-3485	23	64	the	the	DT
en-wikipedia-org-3485	23	65	orexinergic	orexinergic	JJ
en-wikipedia-org-3485	23	66	nucleus	nucleus	NN
en-wikipedia-org-3485	23	67	in	in	IN
en-wikipedia-org-3485	23	68	the	the	DT
en-wikipedia-org-3485	23	69	lateral	lateral	JJ
en-wikipedia-org-3485	23	70	hypothalamus	hypothalamus	NN
en-wikipedia-org-3485	23	71	)	)	-RRB-
en-wikipedia-org-3485	23	72	,	,	,
en-wikipedia-org-3485	23	73	thalamus	thalamus	NNP
en-wikipedia-org-3485	23	74	(	(	-LRB-
en-wikipedia-org-3485	23	75	multiple	multiple	JJ
en-wikipedia-org-3485	23	76	nuclei	nucleus	NNS
en-wikipedia-org-3485	23	77	)	)	-RRB-
en-wikipedia-org-3485	23	78	,	,	,
en-wikipedia-org-3485	23	79	subthalamic	subthalamic	JJ
en-wikipedia-org-3485	23	80	nucleus	nucleus	NNP
en-wikipedia-org-3485	23	81	,	,	,
en-wikipedia-org-3485	23	82	globus	globus	NNP
en-wikipedia-org-3485	23	83	pallidus	pallidus	NNP
en-wikipedia-org-3485	23	84	(	(	-LRB-
en-wikipedia-org-3485	23	85	both	both	CC
en-wikipedia-org-3485	23	86	external	external	JJ
en-wikipedia-org-3485	23	87	and	and	CC
en-wikipedia-org-3485	23	88	internal	internal	JJ
en-wikipedia-org-3485	23	89	)	)	-RRB-
en-wikipedia-org-3485	23	90	,	,	,
en-wikipedia-org-3485	23	91	ventral	ventral	JJ
en-wikipedia-org-3485	23	92	pallidum	pallidum	NN
en-wikipedia-org-3485	23	93	,	,	,
en-wikipedia-org-3485	23	94	parabrachial	parabrachial	JJ
en-wikipedia-org-3485	23	95	nucleus	nucleus	NN
en-wikipedia-org-3485	23	96	,	,	,
en-wikipedia-org-3485	23	97	amygdala	amygdala	NNP
en-wikipedia-org-3485	23	98	,	,	,
en-wikipedia-org-3485	23	99	and	and	CC
en-wikipedia-org-3485	23	100	the	the	DT
en-wikipedia-org-3485	23	101	remainder	remainder	NN
en-wikipedia-org-3485	23	102	of	of	IN
en-wikipedia-org-3485	23	103	the	the	DT
en-wikipedia-org-3485	23	104	extended	extended	JJ
en-wikipedia-org-3485	23	105	amygdala	amygdala	NNP
en-wikipedia-org-3485	23	106	.	.	.
en-wikipedia-org-3485	24	1	[	[	-LRB-
en-wikipedia-org-3485	24	2	2][13][15][16][17	2][13][15][16][17	CD
en-wikipedia-org-3485	24	3	]	]	-RRB-
en-wikipedia-org-3485	24	4	The	the	DT
en-wikipedia-org-3485	24	5	dorsal	dorsal	NN
en-wikipedia-org-3485	24	6	raphe	raphe	NN
en-wikipedia-org-3485	24	7	nucleus	nucleus	NN
en-wikipedia-org-3485	24	8	and	and	CC
en-wikipedia-org-3485	24	9	cerebellum	cerebellum	NN
en-wikipedia-org-3485	24	10	appear	appear	VB
en-wikipedia-org-3485	24	11	to	to	TO
en-wikipedia-org-3485	24	12	modulate	modulate	VB
en-wikipedia-org-3485	24	13	some	some	DT
en-wikipedia-org-3485	24	14	forms	form	NNS
en-wikipedia-org-3485	24	15	of	of	IN
en-wikipedia-org-3485	24	16	reward	reward	NN
en-wikipedia-org-3485	24	17	-	-	HYPH
en-wikipedia-org-3485	24	18	related	relate	VBN
en-wikipedia-org-3485	24	19	cognition	cognition	NN
en-wikipedia-org-3485	24	20	(	(	-LRB-
en-wikipedia-org-3485	24	21	i.e.	i.e.	FW
en-wikipedia-org-3485	24	22	,	,	,
en-wikipedia-org-3485	24	23	associative	associative	JJ
en-wikipedia-org-3485	24	24	learning	learning	NN
en-wikipedia-org-3485	24	25	,	,	,
en-wikipedia-org-3485	24	26	motivational	motivational	JJ
en-wikipedia-org-3485	24	27	salience	salience	NN
en-wikipedia-org-3485	24	28	,	,	,
en-wikipedia-org-3485	24	29	and	and	CC
en-wikipedia-org-3485	24	30	positive	positive	JJ
en-wikipedia-org-3485	24	31	emotions	emotion	NNS
en-wikipedia-org-3485	24	32	)	)	-RRB-
en-wikipedia-org-3485	24	33	and	and	CC
en-wikipedia-org-3485	24	34	behaviors	behavior	NNS
en-wikipedia-org-3485	24	35	as	as	RB
en-wikipedia-org-3485	24	36	well	well	RB
en-wikipedia-org-3485	24	37	.	.	.
en-wikipedia-org-3485	25	1	[	[	-LRB-
en-wikipedia-org-3485	25	2	18][19][20	18][19][20	CD
en-wikipedia-org-3485	25	3	]	]	-RRB-
en-wikipedia-org-3485	25	4	The	the	DT
en-wikipedia-org-3485	25	5	laterodorsal	laterodorsal	NN
en-wikipedia-org-3485	25	6	tegmental	tegmental	JJ
en-wikipedia-org-3485	25	7	nucleus	nucleus	NNP
en-wikipedia-org-3485	25	8	(	(	-LRB-
en-wikipedia-org-3485	25	9	LTD	LTD	NNP
en-wikipedia-org-3485	25	10	)	)	-RRB-
en-wikipedia-org-3485	25	11	,	,	,
en-wikipedia-org-3485	25	12	pedunculopontine	pedunculopontine	JJ
en-wikipedia-org-3485	25	13	nucleus	nucleus	NN
en-wikipedia-org-3485	25	14	(	(	-LRB-
en-wikipedia-org-3485	25	15	PPTg	PPTg	NNP
en-wikipedia-org-3485	25	16	)	)	-RRB-
en-wikipedia-org-3485	25	17	,	,	,
en-wikipedia-org-3485	25	18	and	and	CC
en-wikipedia-org-3485	25	19	lateral	lateral	JJ
en-wikipedia-org-3485	25	20	habenula	habenula	NN
en-wikipedia-org-3485	25	21	(	(	-LRB-
en-wikipedia-org-3485	25	22	LHb	LHb	NNP
en-wikipedia-org-3485	25	23	)	)	-RRB-
en-wikipedia-org-3485	25	24	(	(	-LRB-
en-wikipedia-org-3485	25	25	both	both	DT
en-wikipedia-org-3485	25	26	directly	directly	RB
en-wikipedia-org-3485	25	27	and	and	CC
en-wikipedia-org-3485	25	28	indirectly	indirectly	RB
en-wikipedia-org-3485	25	29	via	via	IN
en-wikipedia-org-3485	25	30	the	the	DT
en-wikipedia-org-3485	25	31	rostromedial	rostromedial	JJ
en-wikipedia-org-3485	25	32	tegmental	tegmental	JJ
en-wikipedia-org-3485	25	33	nucleus	nucleus	NN
en-wikipedia-org-3485	25	34	)	)	-RRB-
en-wikipedia-org-3485	25	35	are	be	VBP
en-wikipedia-org-3485	25	36	also	also	RB
en-wikipedia-org-3485	25	37	capable	capable	JJ
en-wikipedia-org-3485	25	38	of	of	IN
en-wikipedia-org-3485	25	39	inducing	induce	VBG
en-wikipedia-org-3485	25	40	aversive	aversive	JJ
en-wikipedia-org-3485	25	41	salience	salience	NN
en-wikipedia-org-3485	25	42	and	and	CC
en-wikipedia-org-3485	25	43	incentive	incentive	NN
en-wikipedia-org-3485	25	44	salience	salience	NN
en-wikipedia-org-3485	25	45	through	through	IN
en-wikipedia-org-3485	25	46	their	-PRON-	PRP$
en-wikipedia-org-3485	25	47	projections	projection	NNS
en-wikipedia-org-3485	25	48	to	to	IN
en-wikipedia-org-3485	25	49	the	the	DT
en-wikipedia-org-3485	25	50	ventral	ventral	JJ
en-wikipedia-org-3485	25	51	tegmental	tegmental	JJ
en-wikipedia-org-3485	25	52	area	area	NN
en-wikipedia-org-3485	25	53	(	(	-LRB-
en-wikipedia-org-3485	25	54	VTA	VTA	NNP
en-wikipedia-org-3485	25	55	)	)	-RRB-
en-wikipedia-org-3485	25	56	.	.	.
en-wikipedia-org-3485	26	1	[	[	-LRB-
en-wikipedia-org-3485	26	2	21	21	LS
en-wikipedia-org-3485	26	3	]	]	-RRB-
en-wikipedia-org-3485	26	4	The	the	DT
en-wikipedia-org-3485	26	5	LDT	LDT	NNP
en-wikipedia-org-3485	26	6	and	and	CC
en-wikipedia-org-3485	26	7	PPTg	PPTg	NNP
en-wikipedia-org-3485	26	8	both	both	DT
en-wikipedia-org-3485	26	9	send	send	VBP
en-wikipedia-org-3485	26	10	glutaminergic	glutaminergic	NN
en-wikipedia-org-3485	26	11	projections	projection	NNS
en-wikipedia-org-3485	26	12	to	to	IN
en-wikipedia-org-3485	26	13	the	the	DT
en-wikipedia-org-3485	26	14	VTA	vta	NN
en-wikipedia-org-3485	26	15	that	that	WDT
en-wikipedia-org-3485	26	16	synapse	synapse	VBD
en-wikipedia-org-3485	26	17	on	on	IN
en-wikipedia-org-3485	26	18	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	26	19	neurons	neuron	NNS
en-wikipedia-org-3485	26	20	,	,	,
en-wikipedia-org-3485	26	21	both	both	DT
en-wikipedia-org-3485	26	22	of	of	IN
en-wikipedia-org-3485	26	23	which	which	WDT
en-wikipedia-org-3485	26	24	can	can	MD
en-wikipedia-org-3485	26	25	produce	produce	VB
en-wikipedia-org-3485	26	26	incentive	incentive	NN
en-wikipedia-org-3485	26	27	salience	salience	NN
en-wikipedia-org-3485	26	28	.	.	.
en-wikipedia-org-3485	27	1	The	the	DT
en-wikipedia-org-3485	27	2	LHb	LHb	NNS
en-wikipedia-org-3485	27	3	sends	send	VBZ
en-wikipedia-org-3485	27	4	glutaminergic	glutaminergic	JJ
en-wikipedia-org-3485	27	5	projections	projection	NNS
en-wikipedia-org-3485	27	6	,	,	,
en-wikipedia-org-3485	27	7	the	the	DT
en-wikipedia-org-3485	27	8	majority	majority	NN
en-wikipedia-org-3485	27	9	of	of	IN
en-wikipedia-org-3485	27	10	which	which	WDT
en-wikipedia-org-3485	27	11	synapse	synapse	VBD
en-wikipedia-org-3485	27	12	on	on	IN
en-wikipedia-org-3485	27	13	GABAergic	GABAergic	NNP
en-wikipedia-org-3485	27	14	RMTg	RMTg	NNPS
en-wikipedia-org-3485	27	15	neurons	neuron	NNS
en-wikipedia-org-3485	27	16	that	that	WDT
en-wikipedia-org-3485	27	17	in	in	IN
en-wikipedia-org-3485	27	18	turn	turn	NN
en-wikipedia-org-3485	27	19	drive	drive	NN
en-wikipedia-org-3485	27	20	inhibition	inhibition	NN
en-wikipedia-org-3485	27	21	of	of	IN
en-wikipedia-org-3485	27	22	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	27	23	VTA	VTA	NNP
en-wikipedia-org-3485	27	24	neurons	neuron	NNS
en-wikipedia-org-3485	27	25	,	,	,
en-wikipedia-org-3485	27	26	although	although	IN
en-wikipedia-org-3485	27	27	some	some	DT
en-wikipedia-org-3485	27	28	LHb	LHb	NNS
en-wikipedia-org-3485	27	29	projections	projection	NNS
en-wikipedia-org-3485	27	30	terminate	terminate	VBP
en-wikipedia-org-3485	27	31	on	on	IN
en-wikipedia-org-3485	27	32	VTA	VTA	NNP
en-wikipedia-org-3485	27	33	interneurons	interneuron	NNS
en-wikipedia-org-3485	27	34	.	.	.
en-wikipedia-org-3485	28	1	These	these	DT
en-wikipedia-org-3485	28	2	LHb	LHb	NNS
en-wikipedia-org-3485	28	3	projections	projection	NNS
en-wikipedia-org-3485	28	4	are	be	VBP
en-wikipedia-org-3485	28	5	activated	activate	VBN
en-wikipedia-org-3485	28	6	both	both	CC
en-wikipedia-org-3485	28	7	by	by	IN
en-wikipedia-org-3485	28	8	aversive	aversive	JJ
en-wikipedia-org-3485	28	9	stimuli	stimulus	NNS
en-wikipedia-org-3485	28	10	and	and	CC
en-wikipedia-org-3485	28	11	by	by	IN
en-wikipedia-org-3485	28	12	the	the	DT
en-wikipedia-org-3485	28	13	absence	absence	NN
en-wikipedia-org-3485	28	14	of	of	IN
en-wikipedia-org-3485	28	15	an	an	DT
en-wikipedia-org-3485	28	16	expected	expected	JJ
en-wikipedia-org-3485	28	17	reward	reward	NN
en-wikipedia-org-3485	28	18	,	,	,
en-wikipedia-org-3485	28	19	and	and	CC
en-wikipedia-org-3485	28	20	excitation	excitation	NN
en-wikipedia-org-3485	28	21	of	of	IN
en-wikipedia-org-3485	28	22	the	the	DT
en-wikipedia-org-3485	28	23	LHb	LHb	NNS
en-wikipedia-org-3485	28	24	can	can	MD
en-wikipedia-org-3485	28	25	induce	induce	VB
en-wikipedia-org-3485	28	26	aversion	aversion	NN
en-wikipedia-org-3485	28	27	.	.	.
en-wikipedia-org-3485	29	1	[	[	-LRB-
en-wikipedia-org-3485	29	2	22][23][24	22][23][24	CD
en-wikipedia-org-3485	29	3	]	]	-RRB-
en-wikipedia-org-3485	29	4	Most	Most	JJS
en-wikipedia-org-3485	29	5	of	of	IN
en-wikipedia-org-3485	29	6	the	the	DT
en-wikipedia-org-3485	29	7	dopamine	dopamine	NN
en-wikipedia-org-3485	29	8	pathways	pathway	NNS
en-wikipedia-org-3485	29	9	(	(	-LRB-
en-wikipedia-org-3485	29	10	i.e.	i.e.	FW
en-wikipedia-org-3485	29	11	,	,	,
en-wikipedia-org-3485	29	12	neurons	neuron	NNS
en-wikipedia-org-3485	29	13	that	that	WDT
en-wikipedia-org-3485	29	14	use	use	VBP
en-wikipedia-org-3485	29	15	the	the	DT
en-wikipedia-org-3485	29	16	neurotransmitter	neurotransmitter	NNP
en-wikipedia-org-3485	29	17	dopamine	dopamine	NN
en-wikipedia-org-3485	29	18	to	to	TO
en-wikipedia-org-3485	29	19	communicate	communicate	VB
en-wikipedia-org-3485	29	20	with	with	IN
en-wikipedia-org-3485	29	21	other	other	JJ
en-wikipedia-org-3485	29	22	neurons	neuron	NNS
en-wikipedia-org-3485	29	23	)	)	-RRB-
en-wikipedia-org-3485	29	24	that	that	DT
en-wikipedia-org-3485	29	25	project	project	NN
en-wikipedia-org-3485	29	26	out	out	IN
en-wikipedia-org-3485	29	27	of	of	IN
en-wikipedia-org-3485	29	28	the	the	DT
en-wikipedia-org-3485	29	29	ventral	ventral	JJ
en-wikipedia-org-3485	29	30	tegmental	tegmental	JJ
en-wikipedia-org-3485	29	31	area	area	NN
en-wikipedia-org-3485	29	32	are	be	VBP
en-wikipedia-org-3485	29	33	part	part	NN
en-wikipedia-org-3485	29	34	of	of	IN
en-wikipedia-org-3485	29	35	the	the	DT
en-wikipedia-org-3485	29	36	reward	reward	NN
en-wikipedia-org-3485	29	37	system;[13	system;[13	NNPS
en-wikipedia-org-3485	29	38	]	]	-RRB-
en-wikipedia-org-3485	29	39	in	in	IN
en-wikipedia-org-3485	29	40	these	these	DT
en-wikipedia-org-3485	29	41	pathways	pathway	NNS
en-wikipedia-org-3485	29	42	,	,	,
en-wikipedia-org-3485	29	43	dopamine	dopamine	NN
en-wikipedia-org-3485	29	44	acts	act	NNS
en-wikipedia-org-3485	29	45	on	on	IN
en-wikipedia-org-3485	29	46	D1-like	D1-like	NNP
en-wikipedia-org-3485	29	47	receptors	receptor	NNS
en-wikipedia-org-3485	29	48	or	or	CC
en-wikipedia-org-3485	29	49	D2-like	d2-like	NN
en-wikipedia-org-3485	29	50	receptors	receptor	NNS
en-wikipedia-org-3485	29	51	to	to	IN
en-wikipedia-org-3485	29	52	either	either	CC
en-wikipedia-org-3485	29	53	stimulate	stimulate	VB
en-wikipedia-org-3485	29	54	(	(	-LRB-
en-wikipedia-org-3485	29	55	D1-like	d1-like	UH
en-wikipedia-org-3485	29	56	)	)	-RRB-
en-wikipedia-org-3485	29	57	or	or	CC
en-wikipedia-org-3485	29	58	inhibit	inhibit	VB
en-wikipedia-org-3485	29	59	(	(	-LRB-
en-wikipedia-org-3485	29	60	D2-like	d2-like	UH
en-wikipedia-org-3485	29	61	)	)	-RRB-
en-wikipedia-org-3485	29	62	the	the	DT
en-wikipedia-org-3485	29	63	production	production	NN
en-wikipedia-org-3485	29	64	of	of	IN
en-wikipedia-org-3485	29	65	cAMP	camp	NN
en-wikipedia-org-3485	29	66	.	.	.
en-wikipedia-org-3485	30	1	[	[	-LRB-
en-wikipedia-org-3485	30	2	25	25	CD
en-wikipedia-org-3485	30	3	]	]	-RRB-
en-wikipedia-org-3485	30	4	The	the	DT
en-wikipedia-org-3485	30	5	GABAergic	gabaergic	JJ
en-wikipedia-org-3485	30	6	medium	medium	NN
en-wikipedia-org-3485	30	7	spiny	spiny	JJ
en-wikipedia-org-3485	30	8	neurons	neuron	NNS
en-wikipedia-org-3485	30	9	of	of	IN
en-wikipedia-org-3485	30	10	the	the	DT
en-wikipedia-org-3485	30	11	striatum	striatum	NN
en-wikipedia-org-3485	30	12	are	be	VBP
en-wikipedia-org-3485	30	13	components	component	NNS
en-wikipedia-org-3485	30	14	of	of	IN
en-wikipedia-org-3485	30	15	the	the	DT
en-wikipedia-org-3485	30	16	reward	reward	NN
en-wikipedia-org-3485	30	17	system	system	NN
en-wikipedia-org-3485	30	18	as	as	RB
en-wikipedia-org-3485	30	19	well	well	RB
en-wikipedia-org-3485	30	20	.	.	.
en-wikipedia-org-3485	31	1	[	[	-LRB-
en-wikipedia-org-3485	31	2	13	13	CD
en-wikipedia-org-3485	31	3	]	]	-RRB-
en-wikipedia-org-3485	31	4	The	the	DT
en-wikipedia-org-3485	31	5	glutamatergic	glutamatergic	JJ
en-wikipedia-org-3485	31	6	projection	projection	NN
en-wikipedia-org-3485	31	7	nuclei	nucleus	NNS
en-wikipedia-org-3485	31	8	in	in	IN
en-wikipedia-org-3485	31	9	the	the	DT
en-wikipedia-org-3485	31	10	subthalamic	subthalamic	JJ
en-wikipedia-org-3485	31	11	nucleus	nucleus	NN
en-wikipedia-org-3485	31	12	,	,	,
en-wikipedia-org-3485	31	13	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	31	14	cortex	cortex	NNP
en-wikipedia-org-3485	31	15	,	,	,
en-wikipedia-org-3485	31	16	hippocampus	hippocampus	NNP
en-wikipedia-org-3485	31	17	,	,	,
en-wikipedia-org-3485	31	18	thalamus	thalamus	NNP
en-wikipedia-org-3485	31	19	,	,	,
en-wikipedia-org-3485	31	20	and	and	CC
en-wikipedia-org-3485	31	21	amygdala	amygdala	NNP
en-wikipedia-org-3485	31	22	connect	connect	NNP
en-wikipedia-org-3485	31	23	to	to	IN
en-wikipedia-org-3485	31	24	other	other	JJ
en-wikipedia-org-3485	31	25	parts	part	NNS
en-wikipedia-org-3485	31	26	of	of	IN
en-wikipedia-org-3485	31	27	the	the	DT
en-wikipedia-org-3485	31	28	reward	reward	NN
en-wikipedia-org-3485	31	29	system	system	NN
en-wikipedia-org-3485	31	30	via	via	IN
en-wikipedia-org-3485	31	31	glutamate	glutamate	NN
en-wikipedia-org-3485	31	32	pathways	pathway	NNS
en-wikipedia-org-3485	31	33	.	.	.
en-wikipedia-org-3485	32	1	[	[	-LRB-
en-wikipedia-org-3485	32	2	13	13	CD
en-wikipedia-org-3485	32	3	]	]	-RRB-
en-wikipedia-org-3485	32	4	The	the	DT
en-wikipedia-org-3485	32	5	medial	medial	NN
en-wikipedia-org-3485	32	6	forebrain	forebrain	NN
en-wikipedia-org-3485	32	7	bundle	bundle	NN
en-wikipedia-org-3485	32	8	,	,	,
en-wikipedia-org-3485	32	9	which	which	WDT
en-wikipedia-org-3485	32	10	is	be	VBZ
en-wikipedia-org-3485	32	11	a	a	DT
en-wikipedia-org-3485	32	12	set	set	NN
en-wikipedia-org-3485	32	13	of	of	IN
en-wikipedia-org-3485	32	14	many	many	JJ
en-wikipedia-org-3485	32	15	neural	neural	JJ
en-wikipedia-org-3485	32	16	pathways	pathway	NNS
en-wikipedia-org-3485	32	17	that	that	WDT
en-wikipedia-org-3485	32	18	mediate	mediate	VBP
en-wikipedia-org-3485	32	19	brain	brain	NN
en-wikipedia-org-3485	32	20	stimulation	stimulation	NN
en-wikipedia-org-3485	32	21	reward	reward	NN
en-wikipedia-org-3485	32	22	(	(	-LRB-
en-wikipedia-org-3485	32	23	i.e.	i.e.	FW
en-wikipedia-org-3485	32	24	,	,	,
en-wikipedia-org-3485	32	25	reward	reward	VB
en-wikipedia-org-3485	32	26	derived	derive	VBN
en-wikipedia-org-3485	32	27	from	from	IN
en-wikipedia-org-3485	32	28	direct	direct	JJ
en-wikipedia-org-3485	32	29	electrochemical	electrochemical	JJ
en-wikipedia-org-3485	32	30	stimulation	stimulation	NN
en-wikipedia-org-3485	32	31	of	of	IN
en-wikipedia-org-3485	32	32	the	the	DT
en-wikipedia-org-3485	32	33	lateral	lateral	JJ
en-wikipedia-org-3485	32	34	hypothalamus	hypothalamus	NN
en-wikipedia-org-3485	32	35	)	)	-RRB-
en-wikipedia-org-3485	32	36	,	,	,
en-wikipedia-org-3485	32	37	is	be	VBZ
en-wikipedia-org-3485	32	38	also	also	RB
en-wikipedia-org-3485	32	39	a	a	DT
en-wikipedia-org-3485	32	40	component	component	NN
en-wikipedia-org-3485	32	41	of	of	IN
en-wikipedia-org-3485	32	42	the	the	DT
en-wikipedia-org-3485	32	43	reward	reward	NN
en-wikipedia-org-3485	32	44	system	system	NN
en-wikipedia-org-3485	32	45	.	.	.
en-wikipedia-org-3485	33	1	[	[	-LRB-
en-wikipedia-org-3485	33	2	26	26	CD
en-wikipedia-org-3485	33	3	]	]	-RRB-
en-wikipedia-org-3485	33	4	Two	two	CD
en-wikipedia-org-3485	33	5	theories	theory	NNS
en-wikipedia-org-3485	33	6	exist	exist	VBP
en-wikipedia-org-3485	33	7	with	with	IN
en-wikipedia-org-3485	33	8	regard	regard	NN
en-wikipedia-org-3485	33	9	to	to	IN
en-wikipedia-org-3485	33	10	the	the	DT
en-wikipedia-org-3485	33	11	activity	activity	NN
en-wikipedia-org-3485	33	12	of	of	IN
en-wikipedia-org-3485	33	13	the	the	DT
en-wikipedia-org-3485	33	14	nucleus	nucleus	NN
en-wikipedia-org-3485	33	15	accumbens	accumben	NNS
en-wikipedia-org-3485	33	16	and	and	CC
en-wikipedia-org-3485	33	17	the	the	DT
en-wikipedia-org-3485	33	18	generation	generation	NN
en-wikipedia-org-3485	33	19	liking	like	VBG
en-wikipedia-org-3485	33	20	and	and	CC
en-wikipedia-org-3485	33	21	wanting	want	VBG
en-wikipedia-org-3485	33	22	.	.	.
en-wikipedia-org-3485	34	1	The	the	DT
en-wikipedia-org-3485	34	2	inhibition	inhibition	NN
en-wikipedia-org-3485	34	3	(	(	-LRB-
en-wikipedia-org-3485	34	4	or	or	CC
en-wikipedia-org-3485	34	5	hyper­polar­ization	hyper­polar­ization	NN
en-wikipedia-org-3485	34	6	)	)	-RRB-
en-wikipedia-org-3485	34	7	hypothesis	hypothesis	NN
en-wikipedia-org-3485	34	8	proposes	propose	VBZ
en-wikipedia-org-3485	34	9	that	that	IN
en-wikipedia-org-3485	34	10	the	the	DT
en-wikipedia-org-3485	34	11	nucleus	nucleus	NN
en-wikipedia-org-3485	34	12	accumbens	accumben	VBZ
en-wikipedia-org-3485	34	13	exerts	exert	NNS
en-wikipedia-org-3485	34	14	tonic	tonic	NN
en-wikipedia-org-3485	34	15	inhibitory	inhibitory	JJ
en-wikipedia-org-3485	34	16	effects	effect	NNS
en-wikipedia-org-3485	34	17	on	on	IN
en-wikipedia-org-3485	34	18	downstream	downstream	JJ
en-wikipedia-org-3485	34	19	structures	structure	NNS
en-wikipedia-org-3485	34	20	such	such	JJ
en-wikipedia-org-3485	34	21	as	as	IN
en-wikipedia-org-3485	34	22	the	the	DT
en-wikipedia-org-3485	34	23	ventral	ventral	JJ
en-wikipedia-org-3485	34	24	pallidum	pallidum	NN
en-wikipedia-org-3485	34	25	,	,	,
en-wikipedia-org-3485	34	26	hypothalamus	hypothalamus	NN
en-wikipedia-org-3485	34	27	or	or	CC
en-wikipedia-org-3485	34	28	ventral	ventral	JJ
en-wikipedia-org-3485	34	29	tegmental	tegmental	JJ
en-wikipedia-org-3485	34	30	area	area	NN
en-wikipedia-org-3485	34	31	,	,	,
en-wikipedia-org-3485	34	32	and	and	CC
en-wikipedia-org-3485	34	33	that	that	IN
en-wikipedia-org-3485	34	34	in	in	IN
en-wikipedia-org-3485	34	35	inhibiting	inhibit	VBG
en-wikipedia-org-3485	34	36	MSNs	msn	NNS
en-wikipedia-org-3485	34	37	in	in	IN
en-wikipedia-org-3485	34	38	the	the	DT
en-wikipedia-org-3485	34	39	nucleus	nucleus	NN
en-wikipedia-org-3485	34	40	accumbens	accumben	NNS
en-wikipedia-org-3485	34	41	(	(	-LRB-
en-wikipedia-org-3485	34	42	NAcc	NAcc	NNP
en-wikipedia-org-3485	34	43	)	)	-RRB-
en-wikipedia-org-3485	34	44	,	,	,
en-wikipedia-org-3485	34	45	these	these	DT
en-wikipedia-org-3485	34	46	structures	structure	NNS
en-wikipedia-org-3485	34	47	are	be	VBP
en-wikipedia-org-3485	34	48	excited	excited	JJ
en-wikipedia-org-3485	34	49	,	,	,
en-wikipedia-org-3485	34	50	"	"	''
en-wikipedia-org-3485	34	51	releasing	release	VBG
en-wikipedia-org-3485	34	52	"	"	''
en-wikipedia-org-3485	34	53	reward	reward	NN
en-wikipedia-org-3485	34	54	related	related	JJ
en-wikipedia-org-3485	34	55	behavior	behavior	NN
en-wikipedia-org-3485	34	56	.	.	.
en-wikipedia-org-3485	35	1	While	while	IN
en-wikipedia-org-3485	35	2	GABA	GABA	NNP
en-wikipedia-org-3485	35	3	receptor	receptor	NN
en-wikipedia-org-3485	35	4	agonists	agonist	NNS
en-wikipedia-org-3485	35	5	are	be	VBP
en-wikipedia-org-3485	35	6	capable	capable	JJ
en-wikipedia-org-3485	35	7	of	of	IN
en-wikipedia-org-3485	35	8	eliciting	elicit	VBG
en-wikipedia-org-3485	35	9	both	both	DT
en-wikipedia-org-3485	35	10	"	"	``
en-wikipedia-org-3485	35	11	liking	like	VBG
en-wikipedia-org-3485	35	12	"	"	''
en-wikipedia-org-3485	35	13	and	and	CC
en-wikipedia-org-3485	35	14	"	"	``
en-wikipedia-org-3485	35	15	wanting	want	VBG
en-wikipedia-org-3485	35	16	"	"	''
en-wikipedia-org-3485	35	17	reactions	reaction	NNS
en-wikipedia-org-3485	35	18	in	in	IN
en-wikipedia-org-3485	35	19	the	the	DT
en-wikipedia-org-3485	35	20	nucleus	nucleus	NN
en-wikipedia-org-3485	35	21	accumbens	accumbens	NNPS
en-wikipedia-org-3485	35	22	,	,	,
en-wikipedia-org-3485	35	23	glutaminergic	glutaminergic	NN
en-wikipedia-org-3485	35	24	inputs	input	NNS
en-wikipedia-org-3485	35	25	from	from	IN
en-wikipedia-org-3485	35	26	the	the	DT
en-wikipedia-org-3485	35	27	basolateral	basolateral	NNP
en-wikipedia-org-3485	35	28	amygdala	amygdala	NNP
en-wikipedia-org-3485	35	29	,	,	,
en-wikipedia-org-3485	35	30	ventral	ventral	JJ
en-wikipedia-org-3485	35	31	hippocampus	hippocampus	NNP
en-wikipedia-org-3485	35	32	,	,	,
en-wikipedia-org-3485	35	33	and	and	CC
en-wikipedia-org-3485	35	34	medial	medial	NNP
en-wikipedia-org-3485	35	35	prefrontal	prefrontal	JJ
en-wikipedia-org-3485	35	36	cortex	cortex	NNP
en-wikipedia-org-3485	35	37	can	can	MD
en-wikipedia-org-3485	35	38	drive	drive	VB
en-wikipedia-org-3485	35	39	incentive	incentive	NN
en-wikipedia-org-3485	35	40	salience	salience	NN
en-wikipedia-org-3485	35	41	.	.	.
en-wikipedia-org-3485	36	1	Furthermore	furthermore	RB
en-wikipedia-org-3485	36	2	,	,	,
en-wikipedia-org-3485	36	3	while	while	IN
en-wikipedia-org-3485	36	4	most	most	JJS
en-wikipedia-org-3485	36	5	studies	study	NNS
en-wikipedia-org-3485	36	6	find	find	VBP
en-wikipedia-org-3485	36	7	that	that	IN
en-wikipedia-org-3485	36	8	NAcc	NAcc	NNP
en-wikipedia-org-3485	36	9	neurons	neuron	NNS
en-wikipedia-org-3485	36	10	reduce	reduce	VBP
en-wikipedia-org-3485	36	11	firing	firing	NN
en-wikipedia-org-3485	36	12	in	in	IN
en-wikipedia-org-3485	36	13	response	response	NN
en-wikipedia-org-3485	36	14	to	to	TO
en-wikipedia-org-3485	36	15	reward	reward	VB
en-wikipedia-org-3485	36	16	,	,	,
en-wikipedia-org-3485	36	17	a	a	DT
en-wikipedia-org-3485	36	18	number	number	NN
en-wikipedia-org-3485	36	19	of	of	IN
en-wikipedia-org-3485	36	20	studies	study	NNS
en-wikipedia-org-3485	36	21	find	find	VBP
en-wikipedia-org-3485	36	22	the	the	DT
en-wikipedia-org-3485	36	23	opposite	opposite	JJ
en-wikipedia-org-3485	36	24	response	response	NN
en-wikipedia-org-3485	36	25	.	.	.
en-wikipedia-org-3485	37	1	This	this	DT
en-wikipedia-org-3485	37	2	had	have	VBD
en-wikipedia-org-3485	37	3	led	lead	VBN
en-wikipedia-org-3485	37	4	to	to	IN
en-wikipedia-org-3485	37	5	the	the	DT
en-wikipedia-org-3485	37	6	proposal	proposal	NN
en-wikipedia-org-3485	37	7	of	of	IN
en-wikipedia-org-3485	37	8	the	the	DT
en-wikipedia-org-3485	37	9	disinhibition	disinhibition	NN
en-wikipedia-org-3485	37	10	(	(	-LRB-
en-wikipedia-org-3485	37	11	or	or	CC
en-wikipedia-org-3485	37	12	depolarization	depolarization	NN
en-wikipedia-org-3485	37	13	)	)	-RRB-
en-wikipedia-org-3485	37	14	hypothesis	hypothesis	NN
en-wikipedia-org-3485	37	15	,	,	,
en-wikipedia-org-3485	37	16	that	that	WDT
en-wikipedia-org-3485	37	17	proposes	propose	VBZ
en-wikipedia-org-3485	37	18	that	that	IN
en-wikipedia-org-3485	37	19	excitation	excitation	NN
en-wikipedia-org-3485	37	20	or	or	CC
en-wikipedia-org-3485	37	21	NAcc	NAcc	NNP
en-wikipedia-org-3485	37	22	neurons	neuron	NNS
en-wikipedia-org-3485	37	23	,	,	,
en-wikipedia-org-3485	37	24	or	or	CC
en-wikipedia-org-3485	37	25	at	at	IN
en-wikipedia-org-3485	37	26	least	least	JJS
en-wikipedia-org-3485	37	27	certain	certain	JJ
en-wikipedia-org-3485	37	28	subsets	subset	NNS
en-wikipedia-org-3485	37	29	,	,	,
en-wikipedia-org-3485	37	30	drives	drive	NNS
en-wikipedia-org-3485	37	31	reward	reward	VBP
en-wikipedia-org-3485	37	32	related	related	JJ
en-wikipedia-org-3485	37	33	behavior	behavior	NN
en-wikipedia-org-3485	37	34	.	.	.
en-wikipedia-org-3485	38	1	[	[	-LRB-
en-wikipedia-org-3485	38	2	2][27][28	2][27][28	CD
en-wikipedia-org-3485	38	3	]	]	-RRB-
en-wikipedia-org-3485	38	4	After	after	IN
en-wikipedia-org-3485	38	5	nearly	nearly	RB
en-wikipedia-org-3485	38	6	50	50	CD
en-wikipedia-org-3485	38	7	years	year	NNS
en-wikipedia-org-3485	38	8	of	of	IN
en-wikipedia-org-3485	38	9	research	research	NN
en-wikipedia-org-3485	38	10	on	on	IN
en-wikipedia-org-3485	38	11	brain	brain	NN
en-wikipedia-org-3485	38	12	-	-	HYPH
en-wikipedia-org-3485	38	13	stimulation	stimulation	NN
en-wikipedia-org-3485	38	14	reward	reward	NN
en-wikipedia-org-3485	38	15	,	,	,
en-wikipedia-org-3485	38	16	experts	expert	NNS
en-wikipedia-org-3485	38	17	have	have	VBP
en-wikipedia-org-3485	38	18	certified	certify	VBN
en-wikipedia-org-3485	38	19	that	that	IN
en-wikipedia-org-3485	38	20	dozens	dozen	NNS
en-wikipedia-org-3485	38	21	of	of	IN
en-wikipedia-org-3485	38	22	sites	site	NNS
en-wikipedia-org-3485	38	23	in	in	IN
en-wikipedia-org-3485	38	24	the	the	DT
en-wikipedia-org-3485	38	25	brain	brain	NN
en-wikipedia-org-3485	38	26	will	will	MD
en-wikipedia-org-3485	38	27	maintain	maintain	VB
en-wikipedia-org-3485	38	28	intracranial	intracranial	JJ
en-wikipedia-org-3485	38	29	self	self	NN
en-wikipedia-org-3485	38	30	-	-	HYPH
en-wikipedia-org-3485	38	31	stimulation	stimulation	NN
en-wikipedia-org-3485	38	32	.	.	.
en-wikipedia-org-3485	39	1	Regions	region	NNS
en-wikipedia-org-3485	39	2	include	include	VBP
en-wikipedia-org-3485	39	3	the	the	DT
en-wikipedia-org-3485	39	4	lateral	lateral	JJ
en-wikipedia-org-3485	39	5	hypothalamus	hypothalamus	NNP
en-wikipedia-org-3485	39	6	and	and	CC
en-wikipedia-org-3485	39	7	medial	medial	NNP
en-wikipedia-org-3485	39	8	forebrain	forebrain	NNP
en-wikipedia-org-3485	39	9	bundles	bundle	NNS
en-wikipedia-org-3485	39	10	,	,	,
en-wikipedia-org-3485	39	11	which	which	WDT
en-wikipedia-org-3485	39	12	are	be	VBP
en-wikipedia-org-3485	39	13	especially	especially	RB
en-wikipedia-org-3485	39	14	effective	effective	JJ
en-wikipedia-org-3485	39	15	.	.	.
en-wikipedia-org-3485	40	1	Stimulation	stimulation	NN
en-wikipedia-org-3485	40	2	there	there	EX
en-wikipedia-org-3485	40	3	activates	activate	VBZ
en-wikipedia-org-3485	40	4	fibers	fiber	NNS
en-wikipedia-org-3485	40	5	that	that	WDT
en-wikipedia-org-3485	40	6	form	form	VBP
en-wikipedia-org-3485	40	7	the	the	DT
en-wikipedia-org-3485	40	8	ascending	ascend	VBG
en-wikipedia-org-3485	40	9	pathways	pathway	NNS
en-wikipedia-org-3485	40	10	;	;	:
en-wikipedia-org-3485	40	11	the	the	DT
en-wikipedia-org-3485	40	12	ascending	ascend	VBG
en-wikipedia-org-3485	40	13	pathways	pathway	NNS
en-wikipedia-org-3485	40	14	include	include	VBP
en-wikipedia-org-3485	40	15	the	the	DT
en-wikipedia-org-3485	40	16	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	40	17	dopamine	dopamine	NN
en-wikipedia-org-3485	40	18	pathway	pathway	NN
en-wikipedia-org-3485	40	19	,	,	,
en-wikipedia-org-3485	40	20	which	which	WDT
en-wikipedia-org-3485	40	21	projects	project	VBZ
en-wikipedia-org-3485	40	22	from	from	IN
en-wikipedia-org-3485	40	23	the	the	DT
en-wikipedia-org-3485	40	24	ventral	ventral	JJ
en-wikipedia-org-3485	40	25	tegmental	tegmental	JJ
en-wikipedia-org-3485	40	26	area	area	NN
en-wikipedia-org-3485	40	27	to	to	IN
en-wikipedia-org-3485	40	28	the	the	DT
en-wikipedia-org-3485	40	29	nucleus	nucleus	NN
en-wikipedia-org-3485	40	30	accumbens	accumben	NNS
en-wikipedia-org-3485	40	31	.	.	.
en-wikipedia-org-3485	41	1	There	there	EX
en-wikipedia-org-3485	41	2	are	be	VBP
en-wikipedia-org-3485	41	3	several	several	JJ
en-wikipedia-org-3485	41	4	explanations	explanation	NNS
en-wikipedia-org-3485	41	5	as	as	IN
en-wikipedia-org-3485	41	6	to	to	IN
en-wikipedia-org-3485	41	7	why	why	WRB
en-wikipedia-org-3485	41	8	the	the	DT
en-wikipedia-org-3485	41	9	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	41	10	dopamine	dopamine	NN
en-wikipedia-org-3485	41	11	pathway	pathway	NN
en-wikipedia-org-3485	41	12	is	be	VBZ
en-wikipedia-org-3485	41	13	central	central	JJ
en-wikipedia-org-3485	41	14	to	to	IN
en-wikipedia-org-3485	41	15	circuits	circuit	NNS
en-wikipedia-org-3485	41	16	mediating	mediate	VBG
en-wikipedia-org-3485	41	17	reward	reward	NN
en-wikipedia-org-3485	41	18	.	.	.
en-wikipedia-org-3485	42	1	First	first	RB
en-wikipedia-org-3485	42	2	,	,	,
en-wikipedia-org-3485	42	3	there	there	EX
en-wikipedia-org-3485	42	4	is	be	VBZ
en-wikipedia-org-3485	42	5	a	a	DT
en-wikipedia-org-3485	42	6	marked	marked	JJ
en-wikipedia-org-3485	42	7	increase	increase	NN
en-wikipedia-org-3485	42	8	in	in	IN
en-wikipedia-org-3485	42	9	dopamine	dopamine	NN
en-wikipedia-org-3485	42	10	release	release	NN
en-wikipedia-org-3485	42	11	from	from	IN
en-wikipedia-org-3485	42	12	the	the	DT
en-wikipedia-org-3485	42	13	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	42	14	pathway	pathway	NN
en-wikipedia-org-3485	42	15	when	when	WRB
en-wikipedia-org-3485	42	16	animals	animal	NNS
en-wikipedia-org-3485	42	17	engage	engage	VBP
en-wikipedia-org-3485	42	18	in	in	IN
en-wikipedia-org-3485	42	19	intracranial	intracranial	JJ
en-wikipedia-org-3485	42	20	self	self	NN
en-wikipedia-org-3485	42	21	-	-	HYPH
en-wikipedia-org-3485	42	22	stimulation	stimulation	NN
en-wikipedia-org-3485	42	23	.	.	.
en-wikipedia-org-3485	43	1	[	[	-LRB-
en-wikipedia-org-3485	43	2	8	8	CD
en-wikipedia-org-3485	43	3	]	]	-RRB-
en-wikipedia-org-3485	43	4	Second	second	RB
en-wikipedia-org-3485	43	5	,	,	,
en-wikipedia-org-3485	43	6	experiments	experiment	NNS
en-wikipedia-org-3485	43	7	consistently	consistently	RB
en-wikipedia-org-3485	43	8	indicate	indicate	VBP
en-wikipedia-org-3485	43	9	that	that	IN
en-wikipedia-org-3485	43	10	brain	brain	NN
en-wikipedia-org-3485	43	11	-	-	HYPH
en-wikipedia-org-3485	43	12	stimulation	stimulation	NN
en-wikipedia-org-3485	43	13	reward	reward	NN
en-wikipedia-org-3485	43	14	stimulates	stimulate	VBZ
en-wikipedia-org-3485	43	15	the	the	DT
en-wikipedia-org-3485	43	16	reinforcement	reinforcement	NN
en-wikipedia-org-3485	43	17	of	of	IN
en-wikipedia-org-3485	43	18	pathways	pathway	NNS
en-wikipedia-org-3485	43	19	that	that	WDT
en-wikipedia-org-3485	43	20	are	be	VBP
en-wikipedia-org-3485	43	21	normally	normally	RB
en-wikipedia-org-3485	43	22	activated	activate	VBN
en-wikipedia-org-3485	43	23	by	by	IN
en-wikipedia-org-3485	43	24	natural	natural	JJ
en-wikipedia-org-3485	43	25	rewards	reward	NNS
en-wikipedia-org-3485	43	26	,	,	,
en-wikipedia-org-3485	43	27	and	and	CC
en-wikipedia-org-3485	43	28	drug	drug	NN
en-wikipedia-org-3485	43	29	reward	reward	NN
en-wikipedia-org-3485	43	30	or	or	CC
en-wikipedia-org-3485	43	31	intracranial	intracranial	JJ
en-wikipedia-org-3485	43	32	self	self	NN
en-wikipedia-org-3485	43	33	-	-	HYPH
en-wikipedia-org-3485	43	34	stimulation	stimulation	NN
en-wikipedia-org-3485	43	35	can	can	MD
en-wikipedia-org-3485	43	36	exert	exert	VB
en-wikipedia-org-3485	43	37	more	more	RBR
en-wikipedia-org-3485	43	38	powerful	powerful	JJ
en-wikipedia-org-3485	43	39	activation	activation	NN
en-wikipedia-org-3485	43	40	of	of	IN
en-wikipedia-org-3485	43	41	central	central	JJ
en-wikipedia-org-3485	43	42	reward	reward	NN
en-wikipedia-org-3485	43	43	mechanisms	mechanism	NNS
en-wikipedia-org-3485	43	44	because	because	IN
en-wikipedia-org-3485	43	45	they	-PRON-	PRP
en-wikipedia-org-3485	43	46	activate	activate	VBP
en-wikipedia-org-3485	43	47	the	the	DT
en-wikipedia-org-3485	43	48	reward	reward	NN
en-wikipedia-org-3485	43	49	center	center	NN
en-wikipedia-org-3485	43	50	directly	directly	RB
en-wikipedia-org-3485	43	51	rather	rather	RB
en-wikipedia-org-3485	43	52	than	than	IN
en-wikipedia-org-3485	43	53	through	through	IN
en-wikipedia-org-3485	43	54	the	the	DT
en-wikipedia-org-3485	43	55	peripheral	peripheral	JJ
en-wikipedia-org-3485	43	56	nerves	nerve	NNS
en-wikipedia-org-3485	43	57	.	.	.
en-wikipedia-org-3485	44	1	[	[	-LRB-
en-wikipedia-org-3485	44	2	8][29][30	8][29][30	CD
en-wikipedia-org-3485	44	3	]	]	-RRB-
en-wikipedia-org-3485	44	4	Third	Third	NNP
en-wikipedia-org-3485	44	5	,	,	,
en-wikipedia-org-3485	44	6	when	when	WRB
en-wikipedia-org-3485	44	7	animals	animal	NNS
en-wikipedia-org-3485	44	8	are	be	VBP
en-wikipedia-org-3485	44	9	administered	administer	VBN
en-wikipedia-org-3485	44	10	addictive	addictive	JJ
en-wikipedia-org-3485	44	11	drugs	drug	NNS
en-wikipedia-org-3485	44	12	or	or	CC
en-wikipedia-org-3485	44	13	engage	engage	VB
en-wikipedia-org-3485	44	14	in	in	IN
en-wikipedia-org-3485	44	15	naturally	naturally	RB
en-wikipedia-org-3485	44	16	rewarding	rewarding	JJ
en-wikipedia-org-3485	44	17	behaviors	behavior	NNS
en-wikipedia-org-3485	44	18	,	,	,
en-wikipedia-org-3485	44	19	such	such	JJ
en-wikipedia-org-3485	44	20	as	as	IN
en-wikipedia-org-3485	44	21	feeding	feeding	NN
en-wikipedia-org-3485	44	22	or	or	CC
en-wikipedia-org-3485	44	23	sexual	sexual	JJ
en-wikipedia-org-3485	44	24	activity	activity	NN
en-wikipedia-org-3485	44	25	,	,	,
en-wikipedia-org-3485	44	26	there	there	EX
en-wikipedia-org-3485	44	27	is	be	VBZ
en-wikipedia-org-3485	44	28	a	a	DT
en-wikipedia-org-3485	44	29	marked	marked	JJ
en-wikipedia-org-3485	44	30	release	release	NN
en-wikipedia-org-3485	44	31	of	of	IN
en-wikipedia-org-3485	44	32	dopamine	dopamine	NN
en-wikipedia-org-3485	44	33	within	within	IN
en-wikipedia-org-3485	44	34	the	the	DT
en-wikipedia-org-3485	44	35	nucleus	nucleus	NN
en-wikipedia-org-3485	44	36	accumbens	accumben	VBZ
en-wikipedia-org-3485	44	37	.	.	.
en-wikipedia-org-3485	45	1	[	[	-LRB-
en-wikipedia-org-3485	45	2	8	8	CD
en-wikipedia-org-3485	45	3	]	]	-RRB-
en-wikipedia-org-3485	45	4	However	however	RB
en-wikipedia-org-3485	45	5	,	,	,
en-wikipedia-org-3485	45	6	dopamine	dopamine	NN
en-wikipedia-org-3485	45	7	is	be	VBZ
en-wikipedia-org-3485	45	8	not	not	RB
en-wikipedia-org-3485	45	9	the	the	DT
en-wikipedia-org-3485	45	10	only	only	JJ
en-wikipedia-org-3485	45	11	reward	reward	NN
en-wikipedia-org-3485	45	12	compound	compound	NN
en-wikipedia-org-3485	45	13	in	in	IN
en-wikipedia-org-3485	45	14	the	the	DT
en-wikipedia-org-3485	45	15	brain	brain	NN
en-wikipedia-org-3485	45	16	.	.	.
en-wikipedia-org-3485	46	1	Key	key	JJ
en-wikipedia-org-3485	46	2	Pathway[edit	pathway[edit	NN
en-wikipedia-org-3485	46	3	]	]	-RRB-
en-wikipedia-org-3485	46	4	Diagram	diagram	NN
en-wikipedia-org-3485	46	5	showing	show	VBG
en-wikipedia-org-3485	46	6	some	some	DT
en-wikipedia-org-3485	46	7	of	of	IN
en-wikipedia-org-3485	46	8	the	the	DT
en-wikipedia-org-3485	46	9	key	key	JJ
en-wikipedia-org-3485	46	10	components	component	NNS
en-wikipedia-org-3485	46	11	of	of	IN
en-wikipedia-org-3485	46	12	the	the	DT
en-wikipedia-org-3485	46	13	mesocorticolimbic	mesocorticolimbic	JJ
en-wikipedia-org-3485	46	14	(	(	-LRB-
en-wikipedia-org-3485	46	15	"	"	``
en-wikipedia-org-3485	46	16	reward	reward	NN
en-wikipedia-org-3485	46	17	"	"	''
en-wikipedia-org-3485	46	18	)	)	-RRB-
en-wikipedia-org-3485	46	19	circuit	circuit	NN
en-wikipedia-org-3485	46	20	.	.	.
en-wikipedia-org-3485	47	1	Ventral	Ventral	NNP
en-wikipedia-org-3485	47	2	Tegmental	Tegmental	NNP
en-wikipedia-org-3485	47	3	Area	Area	NNP
en-wikipedia-org-3485	47	4	The	the	DT
en-wikipedia-org-3485	47	5	VTA	VTA	NNP
en-wikipedia-org-3485	47	6	is	be	VBZ
en-wikipedia-org-3485	47	7	important	important	JJ
en-wikipedia-org-3485	47	8	in	in	IN
en-wikipedia-org-3485	47	9	responding	respond	VBG
en-wikipedia-org-3485	47	10	to	to	IN
en-wikipedia-org-3485	47	11	stimuli	stimulus	NNS
en-wikipedia-org-3485	47	12	and	and	CC
en-wikipedia-org-3485	47	13	cues	cue	NNS
en-wikipedia-org-3485	47	14	that	that	WDT
en-wikipedia-org-3485	47	15	indicate	indicate	VBP
en-wikipedia-org-3485	47	16	a	a	DT
en-wikipedia-org-3485	47	17	reward	reward	NN
en-wikipedia-org-3485	47	18	is	be	VBZ
en-wikipedia-org-3485	47	19	present	present	JJ
en-wikipedia-org-3485	47	20	.	.	.
en-wikipedia-org-3485	48	1	Rewarding	rewarding	JJ
en-wikipedia-org-3485	48	2	stimuli	stimulus	NNS
en-wikipedia-org-3485	48	3	(	(	-LRB-
en-wikipedia-org-3485	48	4	and	and	CC
en-wikipedia-org-3485	48	5	all	all	DT
en-wikipedia-org-3485	48	6	addicting	addict	VBG
en-wikipedia-org-3485	48	7	drugs	drug	NNS
en-wikipedia-org-3485	48	8	)	)	-RRB-
en-wikipedia-org-3485	48	9	act	act	VB
en-wikipedia-org-3485	48	10	on	on	IN
en-wikipedia-org-3485	48	11	the	the	DT
en-wikipedia-org-3485	48	12	circuit	circuit	NN
en-wikipedia-org-3485	48	13	by	by	IN
en-wikipedia-org-3485	48	14	triggering	trigger	VBG
en-wikipedia-org-3485	48	15	the	the	DT
en-wikipedia-org-3485	48	16	VTA	VTA	NNP
en-wikipedia-org-3485	48	17	to	to	TO
en-wikipedia-org-3485	48	18	release	release	VB
en-wikipedia-org-3485	48	19	dopamine	dopamine	NN
en-wikipedia-org-3485	48	20	signals	signal	NNS
en-wikipedia-org-3485	48	21	to	to	IN
en-wikipedia-org-3485	48	22	the	the	DT
en-wikipedia-org-3485	48	23	nucleus	nucleus	NN
en-wikipedia-org-3485	48	24	accumbens	accumbens	NNPS
en-wikipedia-org-3485	48	25	,	,	,
en-wikipedia-org-3485	48	26	either	either	CC
en-wikipedia-org-3485	48	27	directly	directly	RB
en-wikipedia-org-3485	48	28	or	or	CC
en-wikipedia-org-3485	48	29	indirectly	indirectly	RB
en-wikipedia-org-3485	48	30	.	.	.
en-wikipedia-org-3485	49	1	[	[	-LRB-
en-wikipedia-org-3485	49	2	31	31	CD
en-wikipedia-org-3485	49	3	]	]	-RRB-
en-wikipedia-org-3485	49	4	The	the	DT
en-wikipedia-org-3485	49	5	VTA	vta	NN
en-wikipedia-org-3485	49	6	has	have	VBZ
en-wikipedia-org-3485	49	7	two	two	CD
en-wikipedia-org-3485	49	8	important	important	JJ
en-wikipedia-org-3485	49	9	pathways	pathway	NNS
en-wikipedia-org-3485	49	10	:	:	:
en-wikipedia-org-3485	49	11	The	the	DT
en-wikipedia-org-3485	49	12	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	49	13	pathway	pathway	JJ
en-wikipedia-org-3485	49	14	projecting	projecting	NN
en-wikipedia-org-3485	49	15	to	to	IN
en-wikipedia-org-3485	49	16	limbic	limbic	JJ
en-wikipedia-org-3485	49	17	(	(	-LRB-
en-wikipedia-org-3485	49	18	striatal	striatal	JJ
en-wikipedia-org-3485	49	19	)	)	-RRB-
en-wikipedia-org-3485	49	20	regions	region	NNS
en-wikipedia-org-3485	49	21	and	and	CC
en-wikipedia-org-3485	49	22	underpinning	underpin	VBG
en-wikipedia-org-3485	49	23	the	the	DT
en-wikipedia-org-3485	49	24	motivational	motivational	JJ
en-wikipedia-org-3485	49	25	behaviors	behavior	NNS
en-wikipedia-org-3485	49	26	and	and	CC
en-wikipedia-org-3485	49	27	processes	process	NNS
en-wikipedia-org-3485	49	28	,	,	,
en-wikipedia-org-3485	49	29	and	and	CC
en-wikipedia-org-3485	49	30	the	the	DT
en-wikipedia-org-3485	49	31	mesocortical	mesocortical	JJ
en-wikipedia-org-3485	49	32	pathway	pathway	JJ
en-wikipedia-org-3485	49	33	projecting	project	VBG
en-wikipedia-org-3485	49	34	to	to	IN
en-wikipedia-org-3485	49	35	the	the	DT
en-wikipedia-org-3485	49	36	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	49	37	cortex	cortex	NNP
en-wikipedia-org-3485	49	38	,	,	,
en-wikipedia-org-3485	49	39	underpinning	underpin	VBG
en-wikipedia-org-3485	49	40	cognitive	cognitive	JJ
en-wikipedia-org-3485	49	41	functions	function	NNS
en-wikipedia-org-3485	49	42	,	,	,
en-wikipedia-org-3485	49	43	such	such	JJ
en-wikipedia-org-3485	49	44	as	as	IN
en-wikipedia-org-3485	49	45	learning	learn	VBG
en-wikipedia-org-3485	49	46	external	external	JJ
en-wikipedia-org-3485	49	47	cues	cue	NNS
en-wikipedia-org-3485	49	48	,	,	,
en-wikipedia-org-3485	49	49	etc	etc	FW
en-wikipedia-org-3485	49	50	.	.	.
en-wikipedia-org-3485	50	1	[	[	-LRB-
en-wikipedia-org-3485	50	2	32	32	CD
en-wikipedia-org-3485	50	3	]	]	-RRB-
en-wikipedia-org-3485	50	4	Dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	50	5	neurons	neuron	NNS
en-wikipedia-org-3485	50	6	in	in	IN
en-wikipedia-org-3485	50	7	this	this	DT
en-wikipedia-org-3485	50	8	region	region	NN
en-wikipedia-org-3485	50	9	converts	convert	VBZ
en-wikipedia-org-3485	50	10	the	the	DT
en-wikipedia-org-3485	50	11	amino	amino	NN
en-wikipedia-org-3485	50	12	acid	acid	NN
en-wikipedia-org-3485	50	13	tyrosine	tyrosine	NN
en-wikipedia-org-3485	50	14	into	into	IN
en-wikipedia-org-3485	50	15	DOPA	DOPA	NNP
en-wikipedia-org-3485	50	16	using	use	VBG
en-wikipedia-org-3485	50	17	the	the	DT
en-wikipedia-org-3485	50	18	enzyme	enzyme	NNS
en-wikipedia-org-3485	50	19	tyrosine	tyrosine	VBP
en-wikipedia-org-3485	50	20	hydroxylase	hydroxylase	NN
en-wikipedia-org-3485	50	21	,	,	,
en-wikipedia-org-3485	50	22	which	which	WDT
en-wikipedia-org-3485	50	23	is	be	VBZ
en-wikipedia-org-3485	50	24	then	then	RB
en-wikipedia-org-3485	50	25	converted	convert	VBN
en-wikipedia-org-3485	50	26	to	to	IN
en-wikipedia-org-3485	50	27	dopamine	dopamine	NN
en-wikipedia-org-3485	50	28	using	use	VBG
en-wikipedia-org-3485	50	29	the	the	DT
en-wikipedia-org-3485	50	30	enzyme	enzyme	NNS
en-wikipedia-org-3485	50	31	dopa	dopa	NN
en-wikipedia-org-3485	50	32	-	-	HYPH
en-wikipedia-org-3485	50	33	decarboxylase	decarboxylase	NN
en-wikipedia-org-3485	50	34	.	.	.
en-wikipedia-org-3485	51	1	[	[	-LRB-
en-wikipedia-org-3485	51	2	33	33	CD
en-wikipedia-org-3485	51	3	]	]	-RRB-
en-wikipedia-org-3485	51	4	Striatum	Striatum	NNP
en-wikipedia-org-3485	51	5	(	(	-LRB-
en-wikipedia-org-3485	51	6	Nucleus	Nucleus	NNP
en-wikipedia-org-3485	51	7	Accumbens	Accumbens	NNPS
en-wikipedia-org-3485	51	8	)	)	-RRB-
en-wikipedia-org-3485	51	9	The	the	DT
en-wikipedia-org-3485	51	10	striatum	striatum	NN
en-wikipedia-org-3485	51	11	is	be	VBZ
en-wikipedia-org-3485	51	12	broadly	broadly	RB
en-wikipedia-org-3485	51	13	involved	involve	VBN
en-wikipedia-org-3485	51	14	in	in	IN
en-wikipedia-org-3485	51	15	acquiring	acquire	VBG
en-wikipedia-org-3485	51	16	and	and	CC
en-wikipedia-org-3485	51	17	eliciting	eliciting	JJ
en-wikipedia-org-3485	51	18	learned	learn	VBN
en-wikipedia-org-3485	51	19	behaviors	behavior	NNS
en-wikipedia-org-3485	51	20	in	in	IN
en-wikipedia-org-3485	51	21	response	response	NN
en-wikipedia-org-3485	51	22	to	to	IN
en-wikipedia-org-3485	51	23	a	a	DT
en-wikipedia-org-3485	51	24	rewarding	rewarding	JJ
en-wikipedia-org-3485	51	25	cue	cue	NN
en-wikipedia-org-3485	51	26	.	.	.
en-wikipedia-org-3485	52	1	The	the	DT
en-wikipedia-org-3485	52	2	VTA	VTA	NNP
en-wikipedia-org-3485	52	3	projects	project	VBZ
en-wikipedia-org-3485	52	4	to	to	IN
en-wikipedia-org-3485	52	5	the	the	DT
en-wikipedia-org-3485	52	6	striatum	striatum	NN
en-wikipedia-org-3485	52	7	,	,	,
en-wikipedia-org-3485	52	8	and	and	CC
en-wikipedia-org-3485	52	9	activates	activate	VBZ
en-wikipedia-org-3485	52	10	the	the	DT
en-wikipedia-org-3485	52	11	GABA	GABA	NNP
en-wikipedia-org-3485	52	12	-	-	HYPH
en-wikipedia-org-3485	52	13	ergic	ergic	JJ
en-wikipedia-org-3485	52	14	Medium	Medium	NNP
en-wikipedia-org-3485	52	15	Spiny	Spiny	NNP
en-wikipedia-org-3485	52	16	Neurons	Neurons	NNPS
en-wikipedia-org-3485	52	17	via	via	IN
en-wikipedia-org-3485	52	18	D1	d1	NN
en-wikipedia-org-3485	52	19	and	and	CC
en-wikipedia-org-3485	52	20	D2	D2	NNP
en-wikipedia-org-3485	52	21	receptors	receptor	NNS
en-wikipedia-org-3485	52	22	within	within	IN
en-wikipedia-org-3485	52	23	the	the	DT
en-wikipedia-org-3485	52	24	ventral	ventral	JJ
en-wikipedia-org-3485	52	25	(	(	-LRB-
en-wikipedia-org-3485	52	26	Nucleus	Nucleus	NNP
en-wikipedia-org-3485	52	27	Accumbens	Accumbens	NNPS
en-wikipedia-org-3485	52	28	)	)	-RRB-
en-wikipedia-org-3485	52	29	and	and	CC
en-wikipedia-org-3485	52	30	dorsal	dorsal	NN
en-wikipedia-org-3485	52	31	striatum	striatum	NN
en-wikipedia-org-3485	52	32	.	.	.
en-wikipedia-org-3485	53	1	[	[	-LRB-
en-wikipedia-org-3485	53	2	34	34	CD
en-wikipedia-org-3485	53	3	]	]	-RRB-
en-wikipedia-org-3485	53	4	The	the	DT
en-wikipedia-org-3485	53	5	Ventral	Ventral	NNP
en-wikipedia-org-3485	53	6	Striatum	Striatum	NNP
en-wikipedia-org-3485	53	7	(	(	-LRB-
en-wikipedia-org-3485	53	8	the	the	DT
en-wikipedia-org-3485	53	9	Nucleus	Nucleus	NNP
en-wikipedia-org-3485	53	10	Accumbens	Accumbens	NNPS
en-wikipedia-org-3485	53	11	)	)	-RRB-
en-wikipedia-org-3485	53	12	is	be	VBZ
en-wikipedia-org-3485	53	13	broadly	broadly	RB
en-wikipedia-org-3485	53	14	involved	involve	VBN
en-wikipedia-org-3485	53	15	in	in	IN
en-wikipedia-org-3485	53	16	acquiring	acquire	VBG
en-wikipedia-org-3485	53	17	behavior	behavior	NN
en-wikipedia-org-3485	53	18	when	when	WRB
en-wikipedia-org-3485	53	19	fed	feed	VBN
en-wikipedia-org-3485	53	20	into	into	IN
en-wikipedia-org-3485	53	21	by	by	IN
en-wikipedia-org-3485	53	22	the	the	DT
en-wikipedia-org-3485	53	23	VTA	VTA	NNP
en-wikipedia-org-3485	53	24	,	,	,
en-wikipedia-org-3485	53	25	and	and	CC
en-wikipedia-org-3485	53	26	eliciting	elicit	VBG
en-wikipedia-org-3485	53	27	behavior	behavior	NN
en-wikipedia-org-3485	53	28	when	when	WRB
en-wikipedia-org-3485	53	29	fed	feed	VBN
en-wikipedia-org-3485	53	30	into	into	IN
en-wikipedia-org-3485	53	31	by	by	IN
en-wikipedia-org-3485	53	32	the	the	DT
en-wikipedia-org-3485	53	33	PFC	PFC	NNP
en-wikipedia-org-3485	53	34	.	.	.
en-wikipedia-org-3485	54	1	The	the	DT
en-wikipedia-org-3485	54	2	NAc	NAc	NNS
en-wikipedia-org-3485	54	3	shell	shell	VBD
en-wikipedia-org-3485	54	4	projects	project	NNS
en-wikipedia-org-3485	54	5	to	to	IN
en-wikipedia-org-3485	54	6	the	the	DT
en-wikipedia-org-3485	54	7	pallidum	pallidum	NN
en-wikipedia-org-3485	54	8	and	and	CC
en-wikipedia-org-3485	54	9	the	the	DT
en-wikipedia-org-3485	54	10	VTA	VTA	NNP
en-wikipedia-org-3485	54	11	,	,	,
en-wikipedia-org-3485	54	12	regulating	regulate	VBG
en-wikipedia-org-3485	54	13	limbic	limbic	JJ
en-wikipedia-org-3485	54	14	and	and	CC
en-wikipedia-org-3485	54	15	autonomic	autonomic	JJ
en-wikipedia-org-3485	54	16	functions	function	NNS
en-wikipedia-org-3485	54	17	.	.	.
en-wikipedia-org-3485	55	1	This	this	DT
en-wikipedia-org-3485	55	2	modulates	modulate	VBZ
en-wikipedia-org-3485	55	3	the	the	DT
en-wikipedia-org-3485	55	4	reinforcing	reinforce	VBG
en-wikipedia-org-3485	55	5	properties	property	NNS
en-wikipedia-org-3485	55	6	of	of	IN
en-wikipedia-org-3485	55	7	stimuli	stimulus	NNS
en-wikipedia-org-3485	55	8	,	,	,
en-wikipedia-org-3485	55	9	and	and	CC
en-wikipedia-org-3485	55	10	short	short	JJ
en-wikipedia-org-3485	55	11	term	term	NN
en-wikipedia-org-3485	55	12	aspects	aspect	NNS
en-wikipedia-org-3485	55	13	of	of	IN
en-wikipedia-org-3485	55	14	reward	reward	NN
en-wikipedia-org-3485	55	15	.	.	.
en-wikipedia-org-3485	56	1	The	the	DT
en-wikipedia-org-3485	56	2	NAc	NAc	NNS
en-wikipedia-org-3485	56	3	Core	Core	NNP
en-wikipedia-org-3485	56	4	projects	project	NNS
en-wikipedia-org-3485	56	5	to	to	IN
en-wikipedia-org-3485	56	6	the	the	DT
en-wikipedia-org-3485	56	7	substantia	substantia	NN
en-wikipedia-org-3485	56	8	nigra	nigra	NNP
en-wikipedia-org-3485	56	9	and	and	CC
en-wikipedia-org-3485	56	10	is	be	VBZ
en-wikipedia-org-3485	56	11	involved	involve	VBN
en-wikipedia-org-3485	56	12	in	in	IN
en-wikipedia-org-3485	56	13	the	the	DT
en-wikipedia-org-3485	56	14	development	development	NN
en-wikipedia-org-3485	56	15	of	of	IN
en-wikipedia-org-3485	56	16	reward	reward	NN
en-wikipedia-org-3485	56	17	-	-	HYPH
en-wikipedia-org-3485	56	18	seeking	seek	VBG
en-wikipedia-org-3485	56	19	behaviors	behavior	NNS
en-wikipedia-org-3485	56	20	and	and	CC
en-wikipedia-org-3485	56	21	its	-PRON-	PRP$
en-wikipedia-org-3485	56	22	expression	expression	NN
en-wikipedia-org-3485	56	23	.	.	.
en-wikipedia-org-3485	57	1	It	-PRON-	PRP
en-wikipedia-org-3485	57	2	is	be	VBZ
en-wikipedia-org-3485	57	3	involved	involve	VBN
en-wikipedia-org-3485	57	4	in	in	IN
en-wikipedia-org-3485	57	5	spatial	spatial	JJ
en-wikipedia-org-3485	57	6	learning	learning	NN
en-wikipedia-org-3485	57	7	,	,	,
en-wikipedia-org-3485	57	8	conditional	conditional	JJ
en-wikipedia-org-3485	57	9	response	response	NN
en-wikipedia-org-3485	57	10	,	,	,
en-wikipedia-org-3485	57	11	and	and	CC
en-wikipedia-org-3485	57	12	impulsive	impulsive	JJ
en-wikipedia-org-3485	57	13	choice	choice	NN
en-wikipedia-org-3485	57	14	;	;	:
en-wikipedia-org-3485	57	15	the	the	DT
en-wikipedia-org-3485	57	16	long	long	JJ
en-wikipedia-org-3485	57	17	term	term	NN
en-wikipedia-org-3485	57	18	elements	element	NNS
en-wikipedia-org-3485	57	19	of	of	IN
en-wikipedia-org-3485	57	20	reward	reward	NN
en-wikipedia-org-3485	57	21	.	.	.
en-wikipedia-org-3485	58	1	[	[	-LRB-
en-wikipedia-org-3485	58	2	35	35	CD
en-wikipedia-org-3485	58	3	]	]	-RRB-
en-wikipedia-org-3485	58	4	The	the	DT
en-wikipedia-org-3485	58	5	Dorsal	Dorsal	NNP
en-wikipedia-org-3485	58	6	Striatum	Striatum	NNP
en-wikipedia-org-3485	58	7	is	be	VBZ
en-wikipedia-org-3485	58	8	involved	involve	VBN
en-wikipedia-org-3485	58	9	in	in	IN
en-wikipedia-org-3485	58	10	learning	learning	NN
en-wikipedia-org-3485	58	11	,	,	,
en-wikipedia-org-3485	58	12	the	the	DT
en-wikipedia-org-3485	58	13	Dorsal	Dorsal	NNP
en-wikipedia-org-3485	58	14	Medial	Medial	NNP
en-wikipedia-org-3485	58	15	Striatum	Striatum	NNP
en-wikipedia-org-3485	58	16	in	in	IN
en-wikipedia-org-3485	58	17	goal	goal	NN
en-wikipedia-org-3485	58	18	directed	direct	VBN
en-wikipedia-org-3485	58	19	learning	learning	NN
en-wikipedia-org-3485	58	20	,	,	,
en-wikipedia-org-3485	58	21	and	and	CC
en-wikipedia-org-3485	58	22	the	the	DT
en-wikipedia-org-3485	58	23	Dorsal	Dorsal	NNP
en-wikipedia-org-3485	58	24	Lateral	Lateral	NNP
en-wikipedia-org-3485	58	25	Striatum	Striatum	NNP
en-wikipedia-org-3485	58	26	in	in	IN
en-wikipedia-org-3485	58	27	stimulus	stimulus	JJ
en-wikipedia-org-3485	58	28	-	-	HYPH
en-wikipedia-org-3485	58	29	response	response	NN
en-wikipedia-org-3485	58	30	learning	learning	NN
en-wikipedia-org-3485	58	31	foundational	foundational	JJ
en-wikipedia-org-3485	58	32	to	to	IN
en-wikipedia-org-3485	58	33	Pavlovian	pavlovian	JJ
en-wikipedia-org-3485	58	34	response	response	NN
en-wikipedia-org-3485	58	35	.	.	.
en-wikipedia-org-3485	59	1	[	[	-LRB-
en-wikipedia-org-3485	59	2	36	36	CD
en-wikipedia-org-3485	59	3	]	]	-RRB-
en-wikipedia-org-3485	59	4	On	on	IN
en-wikipedia-org-3485	59	5	repeated	repeat	VBN
en-wikipedia-org-3485	59	6	activation	activation	NN
en-wikipedia-org-3485	59	7	by	by	IN
en-wikipedia-org-3485	59	8	a	a	DT
en-wikipedia-org-3485	59	9	stimuli	stimulus	NNS
en-wikipedia-org-3485	59	10	,	,	,
en-wikipedia-org-3485	59	11	the	the	DT
en-wikipedia-org-3485	59	12	Nucleus	Nucleus	NNP
en-wikipedia-org-3485	59	13	Accumbens	Accumbens	NNPS
en-wikipedia-org-3485	59	14	can	can	MD
en-wikipedia-org-3485	59	15	activate	activate	VB
en-wikipedia-org-3485	59	16	the	the	DT
en-wikipedia-org-3485	59	17	Dorsal	Dorsal	NNP
en-wikipedia-org-3485	59	18	Striatum	Striatum	NNP
en-wikipedia-org-3485	59	19	via	via	IN
en-wikipedia-org-3485	59	20	an	an	DT
en-wikipedia-org-3485	59	21	intrastriatal	intrastriatal	JJ
en-wikipedia-org-3485	59	22	loop	loop	NN
en-wikipedia-org-3485	59	23	.	.	.
en-wikipedia-org-3485	60	1	The	the	DT
en-wikipedia-org-3485	60	2	transition	transition	NN
en-wikipedia-org-3485	60	3	of	of	IN
en-wikipedia-org-3485	60	4	signals	signal	NNS
en-wikipedia-org-3485	60	5	from	from	IN
en-wikipedia-org-3485	60	6	the	the	DT
en-wikipedia-org-3485	60	7	NAc	NAc	NNS
en-wikipedia-org-3485	60	8	to	to	IN
en-wikipedia-org-3485	60	9	the	the	DT
en-wikipedia-org-3485	60	10	DS	DS	NNP
en-wikipedia-org-3485	60	11	allows	allow	VBZ
en-wikipedia-org-3485	60	12	reward	reward	NN
en-wikipedia-org-3485	60	13	associated	associate	VBN
en-wikipedia-org-3485	60	14	cues	cue	NNS
en-wikipedia-org-3485	60	15	to	to	TO
en-wikipedia-org-3485	60	16	activate	activate	VB
en-wikipedia-org-3485	60	17	the	the	DT
en-wikipedia-org-3485	60	18	DS	DS	NNP
en-wikipedia-org-3485	60	19	without	without	IN
en-wikipedia-org-3485	60	20	the	the	DT
en-wikipedia-org-3485	60	21	reward	reward	NN
en-wikipedia-org-3485	60	22	itself	-PRON-	PRP
en-wikipedia-org-3485	60	23	being	be	VBG
en-wikipedia-org-3485	60	24	present	present	JJ
en-wikipedia-org-3485	60	25	.	.	.
en-wikipedia-org-3485	61	1	This	this	DT
en-wikipedia-org-3485	61	2	can	can	MD
en-wikipedia-org-3485	61	3	activate	activate	VB
en-wikipedia-org-3485	61	4	cravings	craving	NNS
en-wikipedia-org-3485	61	5	and	and	CC
en-wikipedia-org-3485	61	6	reward	reward	NN
en-wikipedia-org-3485	61	7	-	-	HYPH
en-wikipedia-org-3485	61	8	seeking	seek	VBG
en-wikipedia-org-3485	61	9	behaviors	behavior	NNS
en-wikipedia-org-3485	61	10	(	(	-LRB-
en-wikipedia-org-3485	61	11	and	and	CC
en-wikipedia-org-3485	61	12	is	be	VBZ
en-wikipedia-org-3485	61	13	responsible	responsible	JJ
en-wikipedia-org-3485	61	14	for	for	IN
en-wikipedia-org-3485	61	15	triggering	trigger	VBG
en-wikipedia-org-3485	61	16	relapse	relapse	NN
en-wikipedia-org-3485	61	17	during	during	IN
en-wikipedia-org-3485	61	18	abstinence	abstinence	NN
en-wikipedia-org-3485	61	19	in	in	IN
en-wikipedia-org-3485	61	20	addiction	addiction	NN
en-wikipedia-org-3485	61	21	)	)	-RRB-
en-wikipedia-org-3485	61	22	.	.	.
en-wikipedia-org-3485	62	1	[	[	-LRB-
en-wikipedia-org-3485	62	2	37	37	CD
en-wikipedia-org-3485	62	3	]	]	-RRB-
en-wikipedia-org-3485	62	4	Prefrontal	Prefrontal	NNP
en-wikipedia-org-3485	62	5	Cortex	Cortex	NNP
en-wikipedia-org-3485	62	6	The	the	DT
en-wikipedia-org-3485	62	7	VTA	VTA	NNP
en-wikipedia-org-3485	62	8	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	62	9	neurons	neuron	NNS
en-wikipedia-org-3485	62	10	project	project	NN
en-wikipedia-org-3485	62	11	to	to	IN
en-wikipedia-org-3485	62	12	the	the	DT
en-wikipedia-org-3485	62	13	PFC	PFC	NNP
en-wikipedia-org-3485	62	14	,	,	,
en-wikipedia-org-3485	62	15	activating	activate	VBG
en-wikipedia-org-3485	62	16	glutaminergic	glutaminergic	JJ
en-wikipedia-org-3485	62	17	neurons	neuron	NNS
en-wikipedia-org-3485	62	18	that	that	WDT
en-wikipedia-org-3485	62	19	project	project	NN
en-wikipedia-org-3485	62	20	to	to	IN
en-wikipedia-org-3485	62	21	multiple	multiple	JJ
en-wikipedia-org-3485	62	22	other	other	JJ
en-wikipedia-org-3485	62	23	regions	region	NNS
en-wikipedia-org-3485	62	24	,	,	,
en-wikipedia-org-3485	62	25	including	include	VBG
en-wikipedia-org-3485	62	26	the	the	DT
en-wikipedia-org-3485	62	27	Dorsal	Dorsal	NNP
en-wikipedia-org-3485	62	28	Striatum	Striatum	NNP
en-wikipedia-org-3485	62	29	and	and	CC
en-wikipedia-org-3485	62	30	NAc	NAc	NNP
en-wikipedia-org-3485	62	31	,	,	,
en-wikipedia-org-3485	62	32	ultimately	ultimately	RB
en-wikipedia-org-3485	62	33	allowing	allow	VBG
en-wikipedia-org-3485	62	34	the	the	DT
en-wikipedia-org-3485	62	35	PFC	PFC	NNP
en-wikipedia-org-3485	62	36	to	to	TO
en-wikipedia-org-3485	62	37	mediate	mediate	VB
en-wikipedia-org-3485	62	38	salience	salience	NN
en-wikipedia-org-3485	62	39	and	and	CC
en-wikipedia-org-3485	62	40	conditional	conditional	JJ
en-wikipedia-org-3485	62	41	behaviors	behavior	NNS
en-wikipedia-org-3485	62	42	in	in	IN
en-wikipedia-org-3485	62	43	response	response	NN
en-wikipedia-org-3485	62	44	to	to	IN
en-wikipedia-org-3485	62	45	stimuli	stimulus	NNS
en-wikipedia-org-3485	62	46	.	.	.
en-wikipedia-org-3485	63	1	[	[	-LRB-
en-wikipedia-org-3485	63	2	38	38	CD
en-wikipedia-org-3485	63	3	]	]	-RRB-
en-wikipedia-org-3485	63	4	Notably	notably	RB
en-wikipedia-org-3485	63	5	,	,	,
en-wikipedia-org-3485	63	6	abstinence	abstinence	NN
en-wikipedia-org-3485	63	7	from	from	IN
en-wikipedia-org-3485	63	8	addicting	addict	VBG
en-wikipedia-org-3485	63	9	drugs	drug	NNS
en-wikipedia-org-3485	63	10	activates	activate	VBZ
en-wikipedia-org-3485	63	11	the	the	DT
en-wikipedia-org-3485	63	12	PFC	PFC	NNP
en-wikipedia-org-3485	63	13	,	,	,
en-wikipedia-org-3485	63	14	glutamatergic	glutamatergic	JJ
en-wikipedia-org-3485	63	15	projection	projection	NN
en-wikipedia-org-3485	63	16	to	to	IN
en-wikipedia-org-3485	63	17	the	the	DT
en-wikipedia-org-3485	63	18	NAc	NAc	NNS
en-wikipedia-org-3485	63	19	,	,	,
en-wikipedia-org-3485	63	20	which	which	WDT
en-wikipedia-org-3485	63	21	leads	lead	VBZ
en-wikipedia-org-3485	63	22	to	to	IN
en-wikipedia-org-3485	63	23	strong	strong	JJ
en-wikipedia-org-3485	63	24	cravings	craving	NNS
en-wikipedia-org-3485	63	25	,	,	,
en-wikipedia-org-3485	63	26	and	and	CC
en-wikipedia-org-3485	63	27	modulates	modulate	VBZ
en-wikipedia-org-3485	63	28	reinstatement	reinstatement	NN
en-wikipedia-org-3485	63	29	of	of	IN
en-wikipedia-org-3485	63	30	addiction	addiction	NN
en-wikipedia-org-3485	63	31	behaviors	behavior	NNS
en-wikipedia-org-3485	63	32	resulting	result	VBG
en-wikipedia-org-3485	63	33	from	from	IN
en-wikipedia-org-3485	63	34	abstinence	abstinence	NN
en-wikipedia-org-3485	63	35	.	.	.
en-wikipedia-org-3485	64	1	The	the	DT
en-wikipedia-org-3485	64	2	PFC	PFC	NNP
en-wikipedia-org-3485	64	3	also	also	RB
en-wikipedia-org-3485	64	4	interacts	interact	VBZ
en-wikipedia-org-3485	64	5	with	with	IN
en-wikipedia-org-3485	64	6	the	the	DT
en-wikipedia-org-3485	64	7	VTA	VTA	NNP
en-wikipedia-org-3485	64	8	through	through	IN
en-wikipedia-org-3485	64	9	the	the	DT
en-wikipedia-org-3485	64	10	mesocortical	mesocortical	JJ
en-wikipedia-org-3485	64	11	pathway	pathway	NN
en-wikipedia-org-3485	64	12	,	,	,
en-wikipedia-org-3485	64	13	and	and	CC
en-wikipedia-org-3485	64	14	helps	help	VBZ
en-wikipedia-org-3485	64	15	associate	associate	VB
en-wikipedia-org-3485	64	16	environmental	environmental	JJ
en-wikipedia-org-3485	64	17	cues	cue	NNS
en-wikipedia-org-3485	64	18	with	with	IN
en-wikipedia-org-3485	64	19	the	the	DT
en-wikipedia-org-3485	64	20	reward	reward	NN
en-wikipedia-org-3485	64	21	.	.	.
en-wikipedia-org-3485	65	1	[	[	-LRB-
en-wikipedia-org-3485	65	2	39	39	CD
en-wikipedia-org-3485	65	3	]	]	-RRB-
en-wikipedia-org-3485	65	4	Hippocampus	Hippocampus	NNP
en-wikipedia-org-3485	65	5	The	the	DT
en-wikipedia-org-3485	65	6	Hippocampus	Hippocampus	NNP
en-wikipedia-org-3485	65	7	has	have	VBZ
en-wikipedia-org-3485	65	8	multiple	multiple	JJ
en-wikipedia-org-3485	65	9	functions	function	NNS
en-wikipedia-org-3485	65	10	,	,	,
en-wikipedia-org-3485	65	11	including	include	VBG
en-wikipedia-org-3485	65	12	in	in	IN
en-wikipedia-org-3485	65	13	the	the	DT
en-wikipedia-org-3485	65	14	creation	creation	NN
en-wikipedia-org-3485	65	15	and	and	CC
en-wikipedia-org-3485	65	16	storage	storage	NN
en-wikipedia-org-3485	65	17	of	of	IN
en-wikipedia-org-3485	65	18	memories	memory	NNS
en-wikipedia-org-3485	65	19	.	.	.
en-wikipedia-org-3485	66	1	In	in	IN
en-wikipedia-org-3485	66	2	the	the	DT
en-wikipedia-org-3485	66	3	reward	reward	NN
en-wikipedia-org-3485	66	4	circuit	circuit	NN
en-wikipedia-org-3485	66	5	,	,	,
en-wikipedia-org-3485	66	6	it	-PRON-	PRP
en-wikipedia-org-3485	66	7	serves	serve	VBZ
en-wikipedia-org-3485	66	8	to	to	IN
en-wikipedia-org-3485	66	9	contextual	contextual	JJ
en-wikipedia-org-3485	66	10	memories	memory	NNS
en-wikipedia-org-3485	66	11	and	and	CC
en-wikipedia-org-3485	66	12	associated	associated	JJ
en-wikipedia-org-3485	66	13	cues	cue	NNS
en-wikipedia-org-3485	66	14	.	.	.
en-wikipedia-org-3485	67	1	It	-PRON-	PRP
en-wikipedia-org-3485	67	2	ultimately	ultimately	RB
en-wikipedia-org-3485	67	3	underpins	underpin	VBZ
en-wikipedia-org-3485	67	4	the	the	DT
en-wikipedia-org-3485	67	5	reinstatement	reinstatement	NN
en-wikipedia-org-3485	67	6	of	of	IN
en-wikipedia-org-3485	67	7	reward	reward	NN
en-wikipedia-org-3485	67	8	-	-	HYPH
en-wikipedia-org-3485	67	9	seeking	seek	VBG
en-wikipedia-org-3485	67	10	behaviors	behavior	NNS
en-wikipedia-org-3485	67	11	via	via	IN
en-wikipedia-org-3485	67	12	cues	cue	NNS
en-wikipedia-org-3485	67	13	,	,	,
en-wikipedia-org-3485	67	14	and	and	CC
en-wikipedia-org-3485	67	15	contextual	contextual	JJ
en-wikipedia-org-3485	67	16	triggers	trigger	NNS
en-wikipedia-org-3485	67	17	.	.	.
en-wikipedia-org-3485	68	1	[	[	-LRB-
en-wikipedia-org-3485	68	2	40	40	CD
en-wikipedia-org-3485	68	3	]	]	-RRB-
en-wikipedia-org-3485	68	4	Amygdala	Amygdala	NNP
en-wikipedia-org-3485	68	5	The	the	DT
en-wikipedia-org-3485	68	6	AMY	AMY	NNP
en-wikipedia-org-3485	68	7	receives	receive	VBZ
en-wikipedia-org-3485	68	8	input	input	NN
en-wikipedia-org-3485	68	9	from	from	IN
en-wikipedia-org-3485	68	10	the	the	DT
en-wikipedia-org-3485	68	11	VTA	VTA	NNP
en-wikipedia-org-3485	68	12	,	,	,
en-wikipedia-org-3485	68	13	and	and	CC
en-wikipedia-org-3485	68	14	outputs	output	NNS
en-wikipedia-org-3485	68	15	to	to	IN
en-wikipedia-org-3485	68	16	the	the	DT
en-wikipedia-org-3485	68	17	NAc	NAc	NNS
en-wikipedia-org-3485	68	18	.	.	.
en-wikipedia-org-3485	69	1	The	the	DT
en-wikipedia-org-3485	69	2	amygdala	amygdala	NN
en-wikipedia-org-3485	69	3	is	be	VBZ
en-wikipedia-org-3485	69	4	important	important	JJ
en-wikipedia-org-3485	69	5	in	in	IN
en-wikipedia-org-3485	69	6	creating	create	VBG
en-wikipedia-org-3485	69	7	powerful	powerful	JJ
en-wikipedia-org-3485	69	8	emotional	emotional	JJ
en-wikipedia-org-3485	69	9	flashbulb	flashbulb	NN
en-wikipedia-org-3485	69	10	memories	memory	NNS
en-wikipedia-org-3485	69	11	,	,	,
en-wikipedia-org-3485	69	12	and	and	CC
en-wikipedia-org-3485	69	13	likely	likely	RB
en-wikipedia-org-3485	69	14	underpins	underpin	VBZ
en-wikipedia-org-3485	69	15	the	the	DT
en-wikipedia-org-3485	69	16	creation	creation	NN
en-wikipedia-org-3485	69	17	of	of	IN
en-wikipedia-org-3485	69	18	strong	strong	JJ
en-wikipedia-org-3485	69	19	cue	cue	NN
en-wikipedia-org-3485	69	20	-	-	HYPH
en-wikipedia-org-3485	69	21	associated	associate	VBN
en-wikipedia-org-3485	69	22	memories	memory	NNS
en-wikipedia-org-3485	69	23	.	.	.
en-wikipedia-org-3485	70	1	[	[	-LRB-
en-wikipedia-org-3485	70	2	41	41	CD
en-wikipedia-org-3485	70	3	]	]	-RRB-
en-wikipedia-org-3485	70	4	It	-PRON-	PRP
en-wikipedia-org-3485	70	5	also	also	RB
en-wikipedia-org-3485	70	6	is	be	VBZ
en-wikipedia-org-3485	70	7	important	important	JJ
en-wikipedia-org-3485	70	8	in	in	IN
en-wikipedia-org-3485	70	9	mediating	mediate	VBG
en-wikipedia-org-3485	70	10	the	the	DT
en-wikipedia-org-3485	70	11	anxiety	anxiety	NN
en-wikipedia-org-3485	70	12	effects	effect	NNS
en-wikipedia-org-3485	70	13	of	of	IN
en-wikipedia-org-3485	70	14	withdrawal	withdrawal	NN
en-wikipedia-org-3485	70	15	,	,	,
en-wikipedia-org-3485	70	16	and	and	CC
en-wikipedia-org-3485	70	17	increased	increase	VBN
en-wikipedia-org-3485	70	18	drug	drug	NN
en-wikipedia-org-3485	70	19	intake	intake	NN
en-wikipedia-org-3485	70	20	in	in	IN
en-wikipedia-org-3485	70	21	addiction	addiction	NN
en-wikipedia-org-3485	70	22	.	.	.
en-wikipedia-org-3485	71	1	[	[	-LRB-
en-wikipedia-org-3485	71	2	42	42	CD
en-wikipedia-org-3485	71	3	]	]	-RRB-
en-wikipedia-org-3485	71	4	Pleasure	pleasure	NN
en-wikipedia-org-3485	71	5	centers[edit	centers[edit	,
en-wikipedia-org-3485	71	6	]	]	-RRB-
en-wikipedia-org-3485	71	7	Pleasure	pleasure	NN
en-wikipedia-org-3485	71	8	is	be	VBZ
en-wikipedia-org-3485	71	9	a	a	DT
en-wikipedia-org-3485	71	10	component	component	NN
en-wikipedia-org-3485	71	11	of	of	IN
en-wikipedia-org-3485	71	12	reward	reward	NN
en-wikipedia-org-3485	71	13	,	,	,
en-wikipedia-org-3485	71	14	but	but	CC
en-wikipedia-org-3485	71	15	not	not	RB
en-wikipedia-org-3485	71	16	all	all	DT
en-wikipedia-org-3485	71	17	rewards	reward	NNS
en-wikipedia-org-3485	71	18	are	be	VBP
en-wikipedia-org-3485	71	19	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	71	20	(	(	-LRB-
en-wikipedia-org-3485	71	21	e.g.	e.g.	RB
en-wikipedia-org-3485	71	22	,	,	,
en-wikipedia-org-3485	71	23	money	money	NN
en-wikipedia-org-3485	71	24	does	do	VBZ
en-wikipedia-org-3485	71	25	not	not	RB
en-wikipedia-org-3485	71	26	elicit	elicit	VB
en-wikipedia-org-3485	71	27	pleasure	pleasure	NN
en-wikipedia-org-3485	71	28	unless	unless	IN
en-wikipedia-org-3485	71	29	this	this	DT
en-wikipedia-org-3485	71	30	response	response	NN
en-wikipedia-org-3485	71	31	is	be	VBZ
en-wikipedia-org-3485	71	32	conditioned	condition	VBN
en-wikipedia-org-3485	71	33	)	)	-RRB-
en-wikipedia-org-3485	71	34	.	.	.
en-wikipedia-org-3485	72	1	[	[	-LRB-
en-wikipedia-org-3485	72	2	1	1	LS
en-wikipedia-org-3485	72	3	]	]	-RRB-
en-wikipedia-org-3485	72	4	Stimuli	Stimuli	NNP
en-wikipedia-org-3485	72	5	that	that	WDT
en-wikipedia-org-3485	72	6	are	be	VBP
en-wikipedia-org-3485	72	7	naturally	naturally	RB
en-wikipedia-org-3485	72	8	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	72	9	,	,	,
en-wikipedia-org-3485	72	10	and	and	CC
en-wikipedia-org-3485	72	11	therefore	therefore	RB
en-wikipedia-org-3485	72	12	attractive	attractive	JJ
en-wikipedia-org-3485	72	13	,	,	,
en-wikipedia-org-3485	72	14	are	be	VBP
en-wikipedia-org-3485	72	15	known	know	VBN
en-wikipedia-org-3485	72	16	as	as	IN
en-wikipedia-org-3485	72	17	intrinsic	intrinsic	JJ
en-wikipedia-org-3485	72	18	rewards	reward	NNS
en-wikipedia-org-3485	72	19	,	,	,
en-wikipedia-org-3485	72	20	whereas	whereas	IN
en-wikipedia-org-3485	72	21	stimuli	stimulus	NNS
en-wikipedia-org-3485	72	22	that	that	WDT
en-wikipedia-org-3485	72	23	are	be	VBP
en-wikipedia-org-3485	72	24	attractive	attractive	JJ
en-wikipedia-org-3485	72	25	and	and	CC
en-wikipedia-org-3485	72	26	motivate	motivate	JJ
en-wikipedia-org-3485	72	27	approach	approach	NN
en-wikipedia-org-3485	72	28	behavior	behavior	NN
en-wikipedia-org-3485	72	29	,	,	,
en-wikipedia-org-3485	72	30	but	but	CC
en-wikipedia-org-3485	72	31	are	be	VBP
en-wikipedia-org-3485	72	32	not	not	RB
en-wikipedia-org-3485	72	33	inherently	inherently	RB
en-wikipedia-org-3485	72	34	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	72	35	,	,	,
en-wikipedia-org-3485	72	36	are	be	VBP
en-wikipedia-org-3485	72	37	termed	term	VBN
en-wikipedia-org-3485	72	38	extrinsic	extrinsic	JJ
en-wikipedia-org-3485	72	39	rewards	reward	NNS
en-wikipedia-org-3485	72	40	.	.	.
en-wikipedia-org-3485	73	1	[	[	-LRB-
en-wikipedia-org-3485	73	2	1	1	LS
en-wikipedia-org-3485	73	3	]	]	-RRB-
en-wikipedia-org-3485	73	4	Extrinsic	Extrinsic	NNP
en-wikipedia-org-3485	73	5	rewards	reward	NNS
en-wikipedia-org-3485	73	6	(	(	-LRB-
en-wikipedia-org-3485	73	7	e.g.	e.g.	RB
en-wikipedia-org-3485	73	8	,	,	,
en-wikipedia-org-3485	73	9	money	money	NN
en-wikipedia-org-3485	73	10	)	)	-RRB-
en-wikipedia-org-3485	73	11	are	be	VBP
en-wikipedia-org-3485	73	12	rewarding	rewarding	JJ
en-wikipedia-org-3485	73	13	as	as	IN
en-wikipedia-org-3485	73	14	a	a	DT
en-wikipedia-org-3485	73	15	result	result	NN
en-wikipedia-org-3485	73	16	of	of	IN
en-wikipedia-org-3485	73	17	a	a	DT
en-wikipedia-org-3485	73	18	learned	learn	VBN
en-wikipedia-org-3485	73	19	association	association	NN
en-wikipedia-org-3485	73	20	with	with	IN
en-wikipedia-org-3485	73	21	an	an	DT
en-wikipedia-org-3485	73	22	intrinsic	intrinsic	JJ
en-wikipedia-org-3485	73	23	reward	reward	NN
en-wikipedia-org-3485	73	24	.	.	.
en-wikipedia-org-3485	74	1	[	[	-LRB-
en-wikipedia-org-3485	74	2	1	1	CD
en-wikipedia-org-3485	74	3	]	]	-RRB-
en-wikipedia-org-3485	74	4	In	in	IN
en-wikipedia-org-3485	74	5	other	other	JJ
en-wikipedia-org-3485	74	6	words	word	NNS
en-wikipedia-org-3485	74	7	,	,	,
en-wikipedia-org-3485	74	8	extrinsic	extrinsic	NN
en-wikipedia-org-3485	74	9	rewards	reward	NNS
en-wikipedia-org-3485	74	10	function	function	NN
en-wikipedia-org-3485	74	11	as	as	IN
en-wikipedia-org-3485	74	12	motivational	motivational	JJ
en-wikipedia-org-3485	74	13	magnets	magnet	NNS
en-wikipedia-org-3485	74	14	that	that	WDT
en-wikipedia-org-3485	74	15	elicit	elicit	NN
en-wikipedia-org-3485	74	16	"	"	``
en-wikipedia-org-3485	74	17	wanting	want	VBG
en-wikipedia-org-3485	74	18	"	"	''
en-wikipedia-org-3485	74	19	,	,	,
en-wikipedia-org-3485	74	20	but	but	CC
en-wikipedia-org-3485	74	21	not	not	RB
en-wikipedia-org-3485	74	22	"	"	``
en-wikipedia-org-3485	74	23	liking	like	VBG
en-wikipedia-org-3485	74	24	"	"	''
en-wikipedia-org-3485	74	25	reactions	reaction	NNS
en-wikipedia-org-3485	74	26	once	once	IN
en-wikipedia-org-3485	74	27	they	-PRON-	PRP
en-wikipedia-org-3485	74	28	have	have	VBP
en-wikipedia-org-3485	74	29	been	be	VBN
en-wikipedia-org-3485	74	30	acquired	acquire	VBN
en-wikipedia-org-3485	74	31	.	.	.
en-wikipedia-org-3485	75	1	[	[	-LRB-
en-wikipedia-org-3485	75	2	1	1	LS
en-wikipedia-org-3485	75	3	]	]	-RRB-
en-wikipedia-org-3485	75	4	The	the	DT
en-wikipedia-org-3485	75	5	reward	reward	NN
en-wikipedia-org-3485	75	6	system	system	NN
en-wikipedia-org-3485	75	7	contains	contain	VBZ
en-wikipedia-org-3485	75	8	pleasure	pleasure	NN
en-wikipedia-org-3485	75	9	centers	center	NNS
en-wikipedia-org-3485	75	10	 	  	_SP
en-wikipedia-org-3485	75	11	or	or	CC
en-wikipedia-org-3485	75	12	hedonic	hedonic	JJ
en-wikipedia-org-3485	75	13	hotspots	hotspot	NNS
en-wikipedia-org-3485	75	14	–	–	:
en-wikipedia-org-3485	75	15	i.e.	i.e.	FW
en-wikipedia-org-3485	75	16	,	,	,
en-wikipedia-org-3485	75	17	brain	brain	NN
en-wikipedia-org-3485	75	18	structures	structure	NNS
en-wikipedia-org-3485	75	19	that	that	WDT
en-wikipedia-org-3485	75	20	mediate	mediate	VBP
en-wikipedia-org-3485	75	21	pleasure	pleasure	NN
en-wikipedia-org-3485	75	22	or	or	CC
en-wikipedia-org-3485	75	23	"	"	``
en-wikipedia-org-3485	75	24	liking	like	VBG
en-wikipedia-org-3485	75	25	"	"	''
en-wikipedia-org-3485	75	26	reactions	reaction	NNS
en-wikipedia-org-3485	75	27	from	from	IN
en-wikipedia-org-3485	75	28	intrinsic	intrinsic	JJ
en-wikipedia-org-3485	75	29	rewards	reward	NNS
en-wikipedia-org-3485	75	30	.	.	.
en-wikipedia-org-3485	76	1	As	as	IN
en-wikipedia-org-3485	76	2	of	of	IN
en-wikipedia-org-3485	76	3	October	October	NNP
en-wikipedia-org-3485	76	4	 	  	_SP
en-wikipedia-org-3485	76	5	2017,[update	2017,[update	NN
en-wikipedia-org-3485	76	6	]	]	-RRB-
en-wikipedia-org-3485	76	7	hedonic	hedonic	JJ
en-wikipedia-org-3485	76	8	hotspots	hotspot	NNS
en-wikipedia-org-3485	76	9	have	have	VBP
en-wikipedia-org-3485	76	10	been	be	VBN
en-wikipedia-org-3485	76	11	identified	identify	VBN
en-wikipedia-org-3485	76	12	in	in	IN
en-wikipedia-org-3485	76	13	subcompartments	subcompartment	NNS
en-wikipedia-org-3485	76	14	within	within	IN
en-wikipedia-org-3485	76	15	the	the	DT
en-wikipedia-org-3485	76	16	nucleus	nucleus	NN
en-wikipedia-org-3485	76	17	accumbens	accumbens	NNPS
en-wikipedia-org-3485	76	18	shell	shell	NNP
en-wikipedia-org-3485	76	19	,	,	,
en-wikipedia-org-3485	76	20	ventral	ventral	JJ
en-wikipedia-org-3485	76	21	pallidum	pallidum	NN
en-wikipedia-org-3485	76	22	,	,	,
en-wikipedia-org-3485	76	23	parabrachial	parabrachial	JJ
en-wikipedia-org-3485	76	24	nucleus	nucleus	NN
en-wikipedia-org-3485	76	25	,	,	,
en-wikipedia-org-3485	76	26	orbitofrontal	orbitofrontal	NNP
en-wikipedia-org-3485	76	27	cortex	cortex	NNP
en-wikipedia-org-3485	76	28	(	(	-LRB-
en-wikipedia-org-3485	76	29	OFC	OFC	NNP
en-wikipedia-org-3485	76	30	)	)	-RRB-
en-wikipedia-org-3485	76	31	,	,	,
en-wikipedia-org-3485	76	32	and	and	CC
en-wikipedia-org-3485	76	33	insular	insular	JJ
en-wikipedia-org-3485	76	34	cortex	cortex	NNP
en-wikipedia-org-3485	76	35	.	.	.
en-wikipedia-org-3485	77	1	[	[	-LRB-
en-wikipedia-org-3485	77	2	2][17][43	2][17][43	CD
en-wikipedia-org-3485	77	3	]	]	-RRB-
en-wikipedia-org-3485	77	4	The	the	DT
en-wikipedia-org-3485	77	5	hotspot	hotspot	NN
en-wikipedia-org-3485	77	6	within	within	IN
en-wikipedia-org-3485	77	7	the	the	DT
en-wikipedia-org-3485	77	8	nucleus	nucleus	NN
en-wikipedia-org-3485	77	9	accumbens	accumbens	NNPS
en-wikipedia-org-3485	77	10	shell	shell	NNP
en-wikipedia-org-3485	77	11	is	be	VBZ
en-wikipedia-org-3485	77	12	located	locate	VBN
en-wikipedia-org-3485	77	13	in	in	IN
en-wikipedia-org-3485	77	14	the	the	DT
en-wikipedia-org-3485	77	15	rostrodorsal	rostrodorsal	NN
en-wikipedia-org-3485	77	16	quadrant	quadrant	NN
en-wikipedia-org-3485	77	17	of	of	IN
en-wikipedia-org-3485	77	18	the	the	DT
en-wikipedia-org-3485	77	19	medial	medial	JJ
en-wikipedia-org-3485	77	20	shell	shell	NN
en-wikipedia-org-3485	77	21	,	,	,
en-wikipedia-org-3485	77	22	while	while	IN
en-wikipedia-org-3485	77	23	the	the	DT
en-wikipedia-org-3485	77	24	hedonic	hedonic	JJ
en-wikipedia-org-3485	77	25	coldspot	coldspot	NN
en-wikipedia-org-3485	77	26	is	be	VBZ
en-wikipedia-org-3485	77	27	located	locate	VBN
en-wikipedia-org-3485	77	28	in	in	IN
en-wikipedia-org-3485	77	29	a	a	DT
en-wikipedia-org-3485	77	30	more	more	JJR
en-wikipedia-org-3485	77	31	posterior	posterior	NN
en-wikipedia-org-3485	77	32	region	region	NN
en-wikipedia-org-3485	77	33	.	.	.
en-wikipedia-org-3485	78	1	The	the	DT
en-wikipedia-org-3485	78	2	posterior	posterior	NN
en-wikipedia-org-3485	78	3	ventral	ventral	JJ
en-wikipedia-org-3485	78	4	pallidum	pallidum	NN
en-wikipedia-org-3485	78	5	also	also	RB
en-wikipedia-org-3485	78	6	contains	contain	VBZ
en-wikipedia-org-3485	78	7	a	a	DT
en-wikipedia-org-3485	78	8	hedonic	hedonic	JJ
en-wikipedia-org-3485	78	9	hotspot	hotspot	NN
en-wikipedia-org-3485	78	10	,	,	,
en-wikipedia-org-3485	78	11	while	while	IN
en-wikipedia-org-3485	78	12	the	the	DT
en-wikipedia-org-3485	78	13	anterior	anterior	NNP
en-wikipedia-org-3485	78	14	ventral	ventral	JJ
en-wikipedia-org-3485	78	15	pallidum	pallidum	NN
en-wikipedia-org-3485	78	16	contains	contain	VBZ
en-wikipedia-org-3485	78	17	a	a	DT
en-wikipedia-org-3485	78	18	hedonic	hedonic	JJ
en-wikipedia-org-3485	78	19	coldspot	coldspot	NN
en-wikipedia-org-3485	78	20	.	.	.
en-wikipedia-org-3485	79	1	Microinjections	microinjection	NNS
en-wikipedia-org-3485	79	2	of	of	IN
en-wikipedia-org-3485	79	3	opioids	opioid	NNS
en-wikipedia-org-3485	79	4	,	,	,
en-wikipedia-org-3485	79	5	endocannabinoids	endocannabinoid	NNS
en-wikipedia-org-3485	79	6	,	,	,
en-wikipedia-org-3485	79	7	and	and	CC
en-wikipedia-org-3485	79	8	orexin	orexin	RB
en-wikipedia-org-3485	79	9	are	be	VBP
en-wikipedia-org-3485	79	10	capable	capable	JJ
en-wikipedia-org-3485	79	11	of	of	IN
en-wikipedia-org-3485	79	12	enhancing	enhance	VBG
en-wikipedia-org-3485	79	13	liking	like	VBG
en-wikipedia-org-3485	79	14	in	in	IN
en-wikipedia-org-3485	79	15	these	these	DT
en-wikipedia-org-3485	79	16	hotspots	hotspot	NNS
en-wikipedia-org-3485	79	17	.	.	.
en-wikipedia-org-3485	80	1	[	[	-LRB-
en-wikipedia-org-3485	80	2	2	2	LS
en-wikipedia-org-3485	80	3	]	]	-RRB-
en-wikipedia-org-3485	80	4	The	the	DT
en-wikipedia-org-3485	80	5	hedonic	hedonic	JJ
en-wikipedia-org-3485	80	6	hotspots	hotspot	NNS
en-wikipedia-org-3485	80	7	located	locate	VBN
en-wikipedia-org-3485	80	8	in	in	IN
en-wikipedia-org-3485	80	9	the	the	DT
en-wikipedia-org-3485	80	10	anterior	anterior	NN
en-wikipedia-org-3485	80	11	OFC	OFC	NNP
en-wikipedia-org-3485	80	12	and	and	CC
en-wikipedia-org-3485	80	13	posterior	posterior	NNP
en-wikipedia-org-3485	80	14	insula	insula	NNP
en-wikipedia-org-3485	80	15	have	have	VBP
en-wikipedia-org-3485	80	16	been	be	VBN
en-wikipedia-org-3485	80	17	demonstrated	demonstrate	VBN
en-wikipedia-org-3485	80	18	to	to	TO
en-wikipedia-org-3485	80	19	respond	respond	VB
en-wikipedia-org-3485	80	20	to	to	IN
en-wikipedia-org-3485	80	21	orexin	orexin	NN
en-wikipedia-org-3485	80	22	and	and	CC
en-wikipedia-org-3485	80	23	opioids	opioid	NNS
en-wikipedia-org-3485	80	24	,	,	,
en-wikipedia-org-3485	80	25	as	as	IN
en-wikipedia-org-3485	80	26	has	have	VBZ
en-wikipedia-org-3485	80	27	the	the	DT
en-wikipedia-org-3485	80	28	overlapping	overlap	VBG
en-wikipedia-org-3485	80	29	hedonic	hedonic	JJ
en-wikipedia-org-3485	80	30	coldspot	coldspot	NN
en-wikipedia-org-3485	80	31	in	in	IN
en-wikipedia-org-3485	80	32	the	the	DT
en-wikipedia-org-3485	80	33	anterior	anterior	NNP
en-wikipedia-org-3485	80	34	insula	insula	NNP
en-wikipedia-org-3485	80	35	and	and	CC
en-wikipedia-org-3485	80	36	posterior	posterior	NNP
en-wikipedia-org-3485	80	37	OFC	OFC	NNP
en-wikipedia-org-3485	80	38	.	.	.
en-wikipedia-org-3485	81	1	[	[	-LRB-
en-wikipedia-org-3485	81	2	43	43	CD
en-wikipedia-org-3485	81	3	]	]	-RRB-
en-wikipedia-org-3485	81	4	On	on	IN
en-wikipedia-org-3485	81	5	the	the	DT
en-wikipedia-org-3485	81	6	other	other	JJ
en-wikipedia-org-3485	81	7	hand	hand	NN
en-wikipedia-org-3485	81	8	,	,	,
en-wikipedia-org-3485	81	9	the	the	DT
en-wikipedia-org-3485	81	10	parabrachial	parabrachial	JJ
en-wikipedia-org-3485	81	11	nucleus	nucleus	NN
en-wikipedia-org-3485	81	12	hotspot	hotspot	NN
en-wikipedia-org-3485	81	13	has	have	VBZ
en-wikipedia-org-3485	81	14	only	only	RB
en-wikipedia-org-3485	81	15	been	be	VBN
en-wikipedia-org-3485	81	16	demonstrated	demonstrate	VBN
en-wikipedia-org-3485	81	17	to	to	TO
en-wikipedia-org-3485	81	18	respond	respond	VB
en-wikipedia-org-3485	81	19	to	to	IN
en-wikipedia-org-3485	81	20	benzodiazepine	benzodiazepine	NN
en-wikipedia-org-3485	81	21	receptor	receptor	NN
en-wikipedia-org-3485	81	22	agonists	agonist	NNS
en-wikipedia-org-3485	81	23	.	.	.
en-wikipedia-org-3485	82	1	[	[	-LRB-
en-wikipedia-org-3485	82	2	2	2	LS
en-wikipedia-org-3485	82	3	]	]	-RRB-
en-wikipedia-org-3485	82	4	Hedonic	hedonic	JJ
en-wikipedia-org-3485	82	5	hotspots	hotspot	NNS
en-wikipedia-org-3485	82	6	are	be	VBP
en-wikipedia-org-3485	82	7	functionally	functionally	RB
en-wikipedia-org-3485	82	8	linked	link	VBN
en-wikipedia-org-3485	82	9	,	,	,
en-wikipedia-org-3485	82	10	in	in	IN
en-wikipedia-org-3485	82	11	that	that	DT
en-wikipedia-org-3485	82	12	activation	activation	NN
en-wikipedia-org-3485	82	13	of	of	IN
en-wikipedia-org-3485	82	14	one	one	CD
en-wikipedia-org-3485	82	15	hotspot	hotspot	NN
en-wikipedia-org-3485	82	16	results	result	NNS
en-wikipedia-org-3485	82	17	in	in	IN
en-wikipedia-org-3485	82	18	the	the	DT
en-wikipedia-org-3485	82	19	recruitment	recruitment	NN
en-wikipedia-org-3485	82	20	of	of	IN
en-wikipedia-org-3485	82	21	the	the	DT
en-wikipedia-org-3485	82	22	others	other	NNS
en-wikipedia-org-3485	82	23	,	,	,
en-wikipedia-org-3485	82	24	as	as	IN
en-wikipedia-org-3485	82	25	indexed	index	VBN
en-wikipedia-org-3485	82	26	by	by	IN
en-wikipedia-org-3485	82	27	the	the	DT
en-wikipedia-org-3485	82	28	induced	induced	JJ
en-wikipedia-org-3485	82	29	expression	expression	NN
en-wikipedia-org-3485	82	30	of	of	IN
en-wikipedia-org-3485	82	31	c	c	NN
en-wikipedia-org-3485	82	32	-	-	HYPH
en-wikipedia-org-3485	82	33	Fos	Fos	NNP
en-wikipedia-org-3485	82	34	,	,	,
en-wikipedia-org-3485	82	35	an	an	DT
en-wikipedia-org-3485	82	36	immediate	immediate	JJ
en-wikipedia-org-3485	82	37	early	early	JJ
en-wikipedia-org-3485	82	38	gene	gene	NN
en-wikipedia-org-3485	82	39	.	.	.
en-wikipedia-org-3485	83	1	Furthermore	furthermore	RB
en-wikipedia-org-3485	83	2	,	,	,
en-wikipedia-org-3485	83	3	inhibition	inhibition	NN
en-wikipedia-org-3485	83	4	of	of	IN
en-wikipedia-org-3485	83	5	one	one	CD
en-wikipedia-org-3485	83	6	hotspot	hotspot	NN
en-wikipedia-org-3485	83	7	results	result	NNS
en-wikipedia-org-3485	83	8	in	in	IN
en-wikipedia-org-3485	83	9	the	the	DT
en-wikipedia-org-3485	83	10	blunting	blunting	NN
en-wikipedia-org-3485	83	11	of	of	IN
en-wikipedia-org-3485	83	12	the	the	DT
en-wikipedia-org-3485	83	13	effects	effect	NNS
en-wikipedia-org-3485	83	14	of	of	IN
en-wikipedia-org-3485	83	15	activating	activate	VBG
en-wikipedia-org-3485	83	16	another	another	DT
en-wikipedia-org-3485	83	17	hotspot	hotspot	NN
en-wikipedia-org-3485	83	18	.	.	.
en-wikipedia-org-3485	84	1	[	[	-LRB-
en-wikipedia-org-3485	84	2	2][43	2][43	CD
en-wikipedia-org-3485	84	3	]	]	-RRB-
en-wikipedia-org-3485	84	4	Therefore	therefore	RB
en-wikipedia-org-3485	84	5	,	,	,
en-wikipedia-org-3485	84	6	the	the	DT
en-wikipedia-org-3485	84	7	simultaneous	simultaneous	JJ
en-wikipedia-org-3485	84	8	activation	activation	NN
en-wikipedia-org-3485	84	9	of	of	IN
en-wikipedia-org-3485	84	10	every	every	DT
en-wikipedia-org-3485	84	11	hedonic	hedonic	JJ
en-wikipedia-org-3485	84	12	hotspot	hotspot	NN
en-wikipedia-org-3485	84	13	within	within	IN
en-wikipedia-org-3485	84	14	the	the	DT
en-wikipedia-org-3485	84	15	reward	reward	NN
en-wikipedia-org-3485	84	16	system	system	NN
en-wikipedia-org-3485	84	17	is	be	VBZ
en-wikipedia-org-3485	84	18	believed	believe	VBN
en-wikipedia-org-3485	84	19	to	to	TO
en-wikipedia-org-3485	84	20	be	be	VB
en-wikipedia-org-3485	84	21	necessary	necessary	JJ
en-wikipedia-org-3485	84	22	for	for	IN
en-wikipedia-org-3485	84	23	generating	generate	VBG
en-wikipedia-org-3485	84	24	the	the	DT
en-wikipedia-org-3485	84	25	sensation	sensation	NN
en-wikipedia-org-3485	84	26	of	of	IN
en-wikipedia-org-3485	84	27	an	an	DT
en-wikipedia-org-3485	84	28	intense	intense	JJ
en-wikipedia-org-3485	84	29	euphoria	euphoria	NN
en-wikipedia-org-3485	84	30	.	.	.
en-wikipedia-org-3485	85	1	[	[	-LRB-
en-wikipedia-org-3485	85	2	44	44	CD
en-wikipedia-org-3485	85	3	]	]	-RRB-
en-wikipedia-org-3485	85	4	Wanting	Wanting	NNP
en-wikipedia-org-3485	85	5	and	and	CC
en-wikipedia-org-3485	85	6	liking[edit	liking[edit	LS
en-wikipedia-org-3485	85	7	]	]	-RRB-
en-wikipedia-org-3485	85	8	Main	main	JJ
en-wikipedia-org-3485	85	9	article	article	NN
en-wikipedia-org-3485	85	10	:	:	:
en-wikipedia-org-3485	85	11	Incentive	incentive	NN
en-wikipedia-org-3485	85	12	salience	salience	NN
en-wikipedia-org-3485	85	13	Tuning	tuning	NN
en-wikipedia-org-3485	85	14	of	of	IN
en-wikipedia-org-3485	85	15	appetitive	appetitive	JJ
en-wikipedia-org-3485	85	16	and	and	CC
en-wikipedia-org-3485	85	17	defensive	defensive	JJ
en-wikipedia-org-3485	85	18	reactions	reaction	NNS
en-wikipedia-org-3485	85	19	in	in	IN
en-wikipedia-org-3485	85	20	the	the	DT
en-wikipedia-org-3485	85	21	nucleus	nucleus	NN
en-wikipedia-org-3485	85	22	accumbens	accumben	VBZ
en-wikipedia-org-3485	85	23	shell	shell	NNP
en-wikipedia-org-3485	85	24	.	.	.
en-wikipedia-org-3485	86	1	(	(	-LRB-
en-wikipedia-org-3485	86	2	Above	above	IN
en-wikipedia-org-3485	86	3	)	)	-RRB-
en-wikipedia-org-3485	86	4	AMPA	AMPA	NNP
en-wikipedia-org-3485	86	5	blockade	blockade	NN
en-wikipedia-org-3485	86	6	requires	require	VBZ
en-wikipedia-org-3485	86	7	D1	d1	NN
en-wikipedia-org-3485	86	8	function	function	NN
en-wikipedia-org-3485	86	9	in	in	IN
en-wikipedia-org-3485	86	10	order	order	NN
en-wikipedia-org-3485	86	11	to	to	TO
en-wikipedia-org-3485	86	12	produce	produce	VB
en-wikipedia-org-3485	86	13	motivated	motivated	JJ
en-wikipedia-org-3485	86	14	behaviors	behavior	NNS
en-wikipedia-org-3485	86	15	,	,	,
en-wikipedia-org-3485	86	16	regardless	regardless	RB
en-wikipedia-org-3485	86	17	of	of	IN
en-wikipedia-org-3485	86	18	valence	valence	NN
en-wikipedia-org-3485	86	19	,	,	,
en-wikipedia-org-3485	86	20	and	and	CC
en-wikipedia-org-3485	86	21	D2	D2	NNP
en-wikipedia-org-3485	86	22	function	function	NN
en-wikipedia-org-3485	86	23	to	to	TO
en-wikipedia-org-3485	86	24	produce	produce	VB
en-wikipedia-org-3485	86	25	defensive	defensive	JJ
en-wikipedia-org-3485	86	26	behaviors	behavior	NNS
en-wikipedia-org-3485	86	27	.	.	.
en-wikipedia-org-3485	87	1	GABA	GABA	NNP
en-wikipedia-org-3485	87	2	agonism	agonism	NN
en-wikipedia-org-3485	87	3	,	,	,
en-wikipedia-org-3485	87	4	on	on	IN
en-wikipedia-org-3485	87	5	the	the	DT
en-wikipedia-org-3485	87	6	other	other	JJ
en-wikipedia-org-3485	87	7	hand	hand	NN
en-wikipedia-org-3485	87	8	,	,	,
en-wikipedia-org-3485	87	9	does	do	VBZ
en-wikipedia-org-3485	87	10	not	not	RB
en-wikipedia-org-3485	87	11	requires	require	VBZ
en-wikipedia-org-3485	87	12	dopamine	dopamine	NN
en-wikipedia-org-3485	87	13	receptor	receptor	NN
en-wikipedia-org-3485	87	14	function	function	NN
en-wikipedia-org-3485	87	15	.	.	.
en-wikipedia-org-3485	88	1	(	(	-LRB-
en-wikipedia-org-3485	88	2	Below)The	below)the	JJ
en-wikipedia-org-3485	88	3	expansion	expansion	NN
en-wikipedia-org-3485	88	4	of	of	IN
en-wikipedia-org-3485	88	5	the	the	DT
en-wikipedia-org-3485	88	6	anatomical	anatomical	JJ
en-wikipedia-org-3485	88	7	regions	region	NNS
en-wikipedia-org-3485	88	8	that	that	WDT
en-wikipedia-org-3485	88	9	produce	produce	VBP
en-wikipedia-org-3485	88	10	defensive	defensive	JJ
en-wikipedia-org-3485	88	11	behaviors	behavior	NNS
en-wikipedia-org-3485	88	12	under	under	IN
en-wikipedia-org-3485	88	13	stress	stress	NN
en-wikipedia-org-3485	88	14	,	,	,
en-wikipedia-org-3485	88	15	and	and	CC
en-wikipedia-org-3485	88	16	appetitive	appetitive	JJ
en-wikipedia-org-3485	88	17	behaviors	behavior	NNS
en-wikipedia-org-3485	88	18	in	in	IN
en-wikipedia-org-3485	88	19	the	the	DT
en-wikipedia-org-3485	88	20	home	home	NN
en-wikipedia-org-3485	88	21	environment	environment	NN
en-wikipedia-org-3485	88	22	produced	produce	VBN
en-wikipedia-org-3485	88	23	by	by	IN
en-wikipedia-org-3485	88	24	AMPA	AMPA	NNP
en-wikipedia-org-3485	88	25	antagonism	antagonism	NN
en-wikipedia-org-3485	88	26	.	.	.
en-wikipedia-org-3485	89	1	This	this	DT
en-wikipedia-org-3485	89	2	flexibility	flexibility	NN
en-wikipedia-org-3485	89	3	is	be	VBZ
en-wikipedia-org-3485	89	4	less	less	RBR
en-wikipedia-org-3485	89	5	evident	evident	JJ
en-wikipedia-org-3485	89	6	with	with	IN
en-wikipedia-org-3485	89	7	GABA	GABA	NNP
en-wikipedia-org-3485	89	8	agonism	agonism	NN
en-wikipedia-org-3485	89	9	.	.	.
en-wikipedia-org-3485	90	1	[	[	-LRB-
en-wikipedia-org-3485	90	2	27	27	CD
en-wikipedia-org-3485	90	3	]	]	-RRB-
en-wikipedia-org-3485	90	4	Incentive	incentive	JJ
en-wikipedia-org-3485	90	5	salience	salience	NN
en-wikipedia-org-3485	90	6	is	be	VBZ
en-wikipedia-org-3485	90	7	the	the	DT
en-wikipedia-org-3485	90	8	"	"	``
en-wikipedia-org-3485	90	9	wanting	want	VBG
en-wikipedia-org-3485	90	10	"	"	''
en-wikipedia-org-3485	90	11	or	or	CC
en-wikipedia-org-3485	90	12	"	"	``
en-wikipedia-org-3485	90	13	desire	desire	NN
en-wikipedia-org-3485	90	14	"	"	''
en-wikipedia-org-3485	90	15	attribute	attribute	NN
en-wikipedia-org-3485	90	16	,	,	,
en-wikipedia-org-3485	90	17	which	which	WDT
en-wikipedia-org-3485	90	18	includes	include	VBZ
en-wikipedia-org-3485	90	19	a	a	DT
en-wikipedia-org-3485	90	20	motivational	motivational	JJ
en-wikipedia-org-3485	90	21	component	component	NN
en-wikipedia-org-3485	90	22	,	,	,
en-wikipedia-org-3485	90	23	that	that	WDT
en-wikipedia-org-3485	90	24	is	be	VBZ
en-wikipedia-org-3485	90	25	assigned	assign	VBN
en-wikipedia-org-3485	90	26	to	to	IN
en-wikipedia-org-3485	90	27	a	a	DT
en-wikipedia-org-3485	90	28	rewarding	rewarding	JJ
en-wikipedia-org-3485	90	29	stimulus	stimulus	NN
en-wikipedia-org-3485	90	30	by	by	IN
en-wikipedia-org-3485	90	31	the	the	DT
en-wikipedia-org-3485	90	32	nucleus	nucleus	NN
en-wikipedia-org-3485	90	33	accumbens	accumbens	NNPS
en-wikipedia-org-3485	90	34	shell	shell	NNP
en-wikipedia-org-3485	90	35	(	(	-LRB-
en-wikipedia-org-3485	90	36	NAcc	NAcc	NNP
en-wikipedia-org-3485	90	37	shell	shell	NNP
en-wikipedia-org-3485	90	38	)	)	-RRB-
en-wikipedia-org-3485	90	39	.	.	.
en-wikipedia-org-3485	91	1	[	[	-LRB-
en-wikipedia-org-3485	91	2	1][45][46	1][45][46	CD
en-wikipedia-org-3485	91	3	]	]	-RRB-
en-wikipedia-org-3485	91	4	The	the	DT
en-wikipedia-org-3485	91	5	degree	degree	NN
en-wikipedia-org-3485	91	6	of	of	IN
en-wikipedia-org-3485	91	7	dopamine	dopamine	NN
en-wikipedia-org-3485	91	8	neurotransmission	neurotransmission	NN
en-wikipedia-org-3485	91	9	into	into	IN
en-wikipedia-org-3485	91	10	the	the	DT
en-wikipedia-org-3485	91	11	NAcc	NAcc	NNP
en-wikipedia-org-3485	91	12	shell	shell	NN
en-wikipedia-org-3485	91	13	from	from	IN
en-wikipedia-org-3485	91	14	the	the	DT
en-wikipedia-org-3485	91	15	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	91	16	pathway	pathway	NN
en-wikipedia-org-3485	91	17	is	be	VBZ
en-wikipedia-org-3485	91	18	highly	highly	RB
en-wikipedia-org-3485	91	19	correlated	correlate	VBN
en-wikipedia-org-3485	91	20	with	with	IN
en-wikipedia-org-3485	91	21	the	the	DT
en-wikipedia-org-3485	91	22	magnitude	magnitude	NN
en-wikipedia-org-3485	91	23	of	of	IN
en-wikipedia-org-3485	91	24	incentive	incentive	NN
en-wikipedia-org-3485	91	25	salience	salience	NN
en-wikipedia-org-3485	91	26	for	for	IN
en-wikipedia-org-3485	91	27	rewarding	rewarding	JJ
en-wikipedia-org-3485	91	28	stimuli	stimulus	NNS
en-wikipedia-org-3485	91	29	.	.	.
en-wikipedia-org-3485	92	1	[	[	-LRB-
en-wikipedia-org-3485	92	2	45	45	CD
en-wikipedia-org-3485	92	3	]	]	-RRB-
en-wikipedia-org-3485	92	4	Activation	activation	NN
en-wikipedia-org-3485	92	5	of	of	IN
en-wikipedia-org-3485	92	6	the	the	DT
en-wikipedia-org-3485	92	7	dorsorostral	dorsorostral	JJ
en-wikipedia-org-3485	92	8	region	region	NN
en-wikipedia-org-3485	92	9	of	of	IN
en-wikipedia-org-3485	92	10	the	the	DT
en-wikipedia-org-3485	92	11	nucleus	nucleus	NN
en-wikipedia-org-3485	92	12	accumbens	accumbens	NNP
en-wikipedia-org-3485	92	13	correlates	correlate	VBZ
en-wikipedia-org-3485	92	14	with	with	IN
en-wikipedia-org-3485	92	15	increases	increase	NNS
en-wikipedia-org-3485	92	16	in	in	IN
en-wikipedia-org-3485	92	17	wanting	want	VBG
en-wikipedia-org-3485	92	18	without	without	IN
en-wikipedia-org-3485	92	19	concurrent	concurrent	JJ
en-wikipedia-org-3485	92	20	increases	increase	NNS
en-wikipedia-org-3485	92	21	in	in	IN
en-wikipedia-org-3485	92	22	liking	like	VBG
en-wikipedia-org-3485	92	23	.	.	.
en-wikipedia-org-3485	93	1	[	[	-LRB-
en-wikipedia-org-3485	93	2	47	47	CD
en-wikipedia-org-3485	93	3	]	]	-RRB-
en-wikipedia-org-3485	93	4	However	however	RB
en-wikipedia-org-3485	93	5	,	,	,
en-wikipedia-org-3485	93	6	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	93	7	neurotransmission	neurotransmission	NN
en-wikipedia-org-3485	93	8	into	into	IN
en-wikipedia-org-3485	93	9	the	the	DT
en-wikipedia-org-3485	93	10	nucleus	nucleus	NN
en-wikipedia-org-3485	93	11	accumbens	accumbens	NNPS
en-wikipedia-org-3485	93	12	shell	shell	NNP
en-wikipedia-org-3485	93	13	is	be	VBZ
en-wikipedia-org-3485	93	14	responsible	responsible	JJ
en-wikipedia-org-3485	93	15	not	not	RB
en-wikipedia-org-3485	93	16	only	only	RB
en-wikipedia-org-3485	93	17	for	for	IN
en-wikipedia-org-3485	93	18	appetitive	appetitive	JJ
en-wikipedia-org-3485	93	19	motivational	motivational	JJ
en-wikipedia-org-3485	93	20	salience	salience	NN
en-wikipedia-org-3485	93	21	(	(	-LRB-
en-wikipedia-org-3485	93	22	i.e.	i.e.	FW
en-wikipedia-org-3485	93	23	,	,	,
en-wikipedia-org-3485	93	24	incentive	incentive	NN
en-wikipedia-org-3485	93	25	salience	salience	NN
en-wikipedia-org-3485	93	26	)	)	-RRB-
en-wikipedia-org-3485	93	27	towards	towards	IN
en-wikipedia-org-3485	93	28	rewarding	rewarding	JJ
en-wikipedia-org-3485	93	29	stimuli	stimulus	NNS
en-wikipedia-org-3485	93	30	,	,	,
en-wikipedia-org-3485	93	31	but	but	CC
en-wikipedia-org-3485	93	32	also	also	RB
en-wikipedia-org-3485	93	33	for	for	IN
en-wikipedia-org-3485	93	34	aversive	aversive	JJ
en-wikipedia-org-3485	93	35	motivational	motivational	JJ
en-wikipedia-org-3485	93	36	salience	salience	NN
en-wikipedia-org-3485	93	37	,	,	,
en-wikipedia-org-3485	93	38	which	which	WDT
en-wikipedia-org-3485	93	39	directs	direct	VBZ
en-wikipedia-org-3485	93	40	behavior	behavior	NN
en-wikipedia-org-3485	93	41	away	away	RB
en-wikipedia-org-3485	93	42	from	from	IN
en-wikipedia-org-3485	93	43	undesirable	undesirable	JJ
en-wikipedia-org-3485	93	44	stimuli	stimulus	NNS
en-wikipedia-org-3485	93	45	.	.	.
en-wikipedia-org-3485	94	1	[	[	-LRB-
en-wikipedia-org-3485	94	2	12][48][49	12][48][49	CD
en-wikipedia-org-3485	94	3	]	]	-RRB-
en-wikipedia-org-3485	94	4	In	in	IN
en-wikipedia-org-3485	94	5	the	the	DT
en-wikipedia-org-3485	94	6	dorsal	dorsal	NN
en-wikipedia-org-3485	94	7	striatum	striatum	NN
en-wikipedia-org-3485	94	8	,	,	,
en-wikipedia-org-3485	94	9	activation	activation	NN
en-wikipedia-org-3485	94	10	of	of	IN
en-wikipedia-org-3485	94	11	D1	d1	NN
en-wikipedia-org-3485	94	12	expressing	express	VBG
en-wikipedia-org-3485	94	13	MSNs	msn	NNS
en-wikipedia-org-3485	94	14	produces	produce	VBZ
en-wikipedia-org-3485	94	15	appetitive	appetitive	JJ
en-wikipedia-org-3485	94	16	incentive	incentive	NN
en-wikipedia-org-3485	94	17	salience	salience	NN
en-wikipedia-org-3485	94	18	,	,	,
en-wikipedia-org-3485	94	19	while	while	IN
en-wikipedia-org-3485	94	20	activation	activation	NN
en-wikipedia-org-3485	94	21	of	of	IN
en-wikipedia-org-3485	94	22	D2	d2	NN
en-wikipedia-org-3485	94	23	expressing	express	VBG
en-wikipedia-org-3485	94	24	MSNs	msn	NNS
en-wikipedia-org-3485	94	25	produces	produce	VBZ
en-wikipedia-org-3485	94	26	aversion	aversion	NN
en-wikipedia-org-3485	94	27	.	.	.
en-wikipedia-org-3485	95	1	In	in	IN
en-wikipedia-org-3485	95	2	the	the	DT
en-wikipedia-org-3485	95	3	NAcc	NAcc	NNP
en-wikipedia-org-3485	95	4	,	,	,
en-wikipedia-org-3485	95	5	such	such	PDT
en-wikipedia-org-3485	95	6	a	a	DT
en-wikipedia-org-3485	95	7	dichotomy	dichotomy	NN
en-wikipedia-org-3485	95	8	is	be	VBZ
en-wikipedia-org-3485	95	9	not	not	RB
en-wikipedia-org-3485	95	10	as	as	RB
en-wikipedia-org-3485	95	11	clear	clear	JJ
en-wikipedia-org-3485	95	12	cut	cut	NN
en-wikipedia-org-3485	95	13	,	,	,
en-wikipedia-org-3485	95	14	and	and	CC
en-wikipedia-org-3485	95	15	activation	activation	NN
en-wikipedia-org-3485	95	16	of	of	IN
en-wikipedia-org-3485	95	17	both	both	CC
en-wikipedia-org-3485	95	18	D1	D1	NNP
en-wikipedia-org-3485	95	19	and	and	CC
en-wikipedia-org-3485	95	20	D2	D2	NNP
en-wikipedia-org-3485	95	21	MSNs	MSNs	NNPS
en-wikipedia-org-3485	95	22	is	be	VBZ
en-wikipedia-org-3485	95	23	sufficient	sufficient	JJ
en-wikipedia-org-3485	95	24	to	to	TO
en-wikipedia-org-3485	95	25	enhance	enhance	VB
en-wikipedia-org-3485	95	26	motivation,[50][51	motivation,[50][51	NNS
en-wikipedia-org-3485	95	27	]	]	-RRB-
en-wikipedia-org-3485	95	28	likely	likely	RB
en-wikipedia-org-3485	95	29	via	via	IN
en-wikipedia-org-3485	95	30	disinhibiting	disinhibite	VBG
en-wikipedia-org-3485	95	31	the	the	DT
en-wikipedia-org-3485	95	32	VTA	VTA	NNP
en-wikipedia-org-3485	95	33	through	through	IN
en-wikipedia-org-3485	95	34	inhibiting	inhibit	VBG
en-wikipedia-org-3485	95	35	the	the	DT
en-wikipedia-org-3485	95	36	ventral	ventral	JJ
en-wikipedia-org-3485	95	37	pallidum	pallidum	NN
en-wikipedia-org-3485	95	38	.	.	.
en-wikipedia-org-3485	96	1	[	[	-LRB-
en-wikipedia-org-3485	96	2	52][53	52][53	CD
en-wikipedia-org-3485	96	3	]	]	-RRB-
en-wikipedia-org-3485	96	4	Robinson	Robinson	NNP
en-wikipedia-org-3485	96	5	and	and	CC
en-wikipedia-org-3485	96	6	Berridge	Berridge	NNP
en-wikipedia-org-3485	96	7	's	's	POS
en-wikipedia-org-3485	96	8	1993	1993	CD
en-wikipedia-org-3485	96	9	incentive	incentive	NN
en-wikipedia-org-3485	96	10	-	-	HYPH
en-wikipedia-org-3485	96	11	sensitization	sensitization	NN
en-wikipedia-org-3485	96	12	theory	theory	NN
en-wikipedia-org-3485	96	13	proposed	propose	VBD
en-wikipedia-org-3485	96	14	that	that	IN
en-wikipedia-org-3485	96	15	reward	reward	NN
en-wikipedia-org-3485	96	16	contains	contain	VBZ
en-wikipedia-org-3485	96	17	separable	separable	JJ
en-wikipedia-org-3485	96	18	psychological	psychological	JJ
en-wikipedia-org-3485	96	19	components	component	NNS
en-wikipedia-org-3485	96	20	:	:	:
en-wikipedia-org-3485	96	21	wanting	want	VBG
en-wikipedia-org-3485	96	22	(	(	-LRB-
en-wikipedia-org-3485	96	23	incentive	incentive	NN
en-wikipedia-org-3485	96	24	)	)	-RRB-
en-wikipedia-org-3485	96	25	and	and	CC
en-wikipedia-org-3485	96	26	liking	like	VBG
en-wikipedia-org-3485	96	27	(	(	-LRB-
en-wikipedia-org-3485	96	28	pleasure	pleasure	NN
en-wikipedia-org-3485	96	29	)	)	-RRB-
en-wikipedia-org-3485	96	30	.	.	.
en-wikipedia-org-3485	97	1	To	to	TO
en-wikipedia-org-3485	97	2	explain	explain	VB
en-wikipedia-org-3485	97	3	increasing	increase	VBG
en-wikipedia-org-3485	97	4	contact	contact	NN
en-wikipedia-org-3485	97	5	with	with	IN
en-wikipedia-org-3485	97	6	a	a	DT
en-wikipedia-org-3485	97	7	certain	certain	JJ
en-wikipedia-org-3485	97	8	stimulus	stimulus	NN
en-wikipedia-org-3485	97	9	such	such	JJ
en-wikipedia-org-3485	97	10	as	as	IN
en-wikipedia-org-3485	97	11	chocolate	chocolate	NN
en-wikipedia-org-3485	97	12	,	,	,
en-wikipedia-org-3485	97	13	there	there	EX
en-wikipedia-org-3485	97	14	are	be	VBP
en-wikipedia-org-3485	97	15	two	two	CD
en-wikipedia-org-3485	97	16	independent	independent	JJ
en-wikipedia-org-3485	97	17	factors	factor	NNS
en-wikipedia-org-3485	97	18	at	at	IN
en-wikipedia-org-3485	97	19	work	work	NN
en-wikipedia-org-3485	97	20	–	–	:
en-wikipedia-org-3485	97	21	our	-PRON-	PRP$
en-wikipedia-org-3485	97	22	desire	desire	NN
en-wikipedia-org-3485	97	23	to	to	TO
en-wikipedia-org-3485	97	24	have	have	VB
en-wikipedia-org-3485	97	25	the	the	DT
en-wikipedia-org-3485	97	26	chocolate	chocolate	NN
en-wikipedia-org-3485	97	27	(	(	-LRB-
en-wikipedia-org-3485	97	28	wanting	want	VBG
en-wikipedia-org-3485	97	29	)	)	-RRB-
en-wikipedia-org-3485	97	30	and	and	CC
en-wikipedia-org-3485	97	31	the	the	DT
en-wikipedia-org-3485	97	32	pleasure	pleasure	NN
en-wikipedia-org-3485	97	33	effect	effect	NN
en-wikipedia-org-3485	97	34	of	of	IN
en-wikipedia-org-3485	97	35	the	the	DT
en-wikipedia-org-3485	97	36	chocolate	chocolate	NN
en-wikipedia-org-3485	97	37	(	(	-LRB-
en-wikipedia-org-3485	97	38	liking	liking	NN
en-wikipedia-org-3485	97	39	)	)	-RRB-
en-wikipedia-org-3485	97	40	.	.	.
en-wikipedia-org-3485	98	1	According	accord	VBG
en-wikipedia-org-3485	98	2	to	to	IN
en-wikipedia-org-3485	98	3	Robinson	Robinson	NNP
en-wikipedia-org-3485	98	4	and	and	CC
en-wikipedia-org-3485	98	5	Berridge	Berridge	NNP
en-wikipedia-org-3485	98	6	,	,	,
en-wikipedia-org-3485	98	7	wanting	want	VBG
en-wikipedia-org-3485	98	8	and	and	CC
en-wikipedia-org-3485	98	9	liking	like	VBG
en-wikipedia-org-3485	98	10	are	be	VBP
en-wikipedia-org-3485	98	11	two	two	CD
en-wikipedia-org-3485	98	12	aspects	aspect	NNS
en-wikipedia-org-3485	98	13	of	of	IN
en-wikipedia-org-3485	98	14	the	the	DT
en-wikipedia-org-3485	98	15	same	same	JJ
en-wikipedia-org-3485	98	16	process	process	NN
en-wikipedia-org-3485	98	17	,	,	,
en-wikipedia-org-3485	98	18	so	so	IN
en-wikipedia-org-3485	98	19	rewards	reward	NNS
en-wikipedia-org-3485	98	20	are	be	VBP
en-wikipedia-org-3485	98	21	usually	usually	RB
en-wikipedia-org-3485	98	22	wanted	want	VBN
en-wikipedia-org-3485	98	23	and	and	CC
en-wikipedia-org-3485	98	24	liked	like	VBD
en-wikipedia-org-3485	98	25	to	to	IN
en-wikipedia-org-3485	98	26	the	the	DT
en-wikipedia-org-3485	98	27	same	same	JJ
en-wikipedia-org-3485	98	28	degree	degree	NN
en-wikipedia-org-3485	98	29	.	.	.
en-wikipedia-org-3485	99	1	However	however	RB
en-wikipedia-org-3485	99	2	,	,	,
en-wikipedia-org-3485	99	3	wanting	want	VBG
en-wikipedia-org-3485	99	4	and	and	CC
en-wikipedia-org-3485	99	5	liking	liking	NN
en-wikipedia-org-3485	99	6	also	also	RB
en-wikipedia-org-3485	99	7	change	change	VBP
en-wikipedia-org-3485	99	8	independently	independently	RB
en-wikipedia-org-3485	99	9	under	under	IN
en-wikipedia-org-3485	99	10	certain	certain	JJ
en-wikipedia-org-3485	99	11	circumstances	circumstance	NNS
en-wikipedia-org-3485	99	12	.	.	.
en-wikipedia-org-3485	100	1	For	for	IN
en-wikipedia-org-3485	100	2	example	example	NN
en-wikipedia-org-3485	100	3	,	,	,
en-wikipedia-org-3485	100	4	rats	rat	NNS
en-wikipedia-org-3485	100	5	that	that	WDT
en-wikipedia-org-3485	100	6	do	do	VBP
en-wikipedia-org-3485	100	7	not	not	RB
en-wikipedia-org-3485	100	8	eat	eat	VB
en-wikipedia-org-3485	100	9	after	after	IN
en-wikipedia-org-3485	100	10	receiving	receive	VBG
en-wikipedia-org-3485	100	11	dopamine	dopamine	NN
en-wikipedia-org-3485	100	12	(	(	-LRB-
en-wikipedia-org-3485	100	13	experiencing	experience	VBG
en-wikipedia-org-3485	100	14	a	a	DT
en-wikipedia-org-3485	100	15	loss	loss	NN
en-wikipedia-org-3485	100	16	of	of	IN
en-wikipedia-org-3485	100	17	desire	desire	NN
en-wikipedia-org-3485	100	18	for	for	IN
en-wikipedia-org-3485	100	19	food	food	NN
en-wikipedia-org-3485	100	20	)	)	-RRB-
en-wikipedia-org-3485	100	21	act	act	VB
en-wikipedia-org-3485	100	22	as	as	IN
en-wikipedia-org-3485	100	23	though	though	IN
en-wikipedia-org-3485	100	24	they	-PRON-	PRP
en-wikipedia-org-3485	100	25	still	still	RB
en-wikipedia-org-3485	100	26	like	like	VBP
en-wikipedia-org-3485	100	27	food	food	NN
en-wikipedia-org-3485	100	28	.	.	.
en-wikipedia-org-3485	101	1	In	in	IN
en-wikipedia-org-3485	101	2	another	another	DT
en-wikipedia-org-3485	101	3	example	example	NN
en-wikipedia-org-3485	101	4	,	,	,
en-wikipedia-org-3485	101	5	activated	activate	VBN
en-wikipedia-org-3485	101	6	self	self	NN
en-wikipedia-org-3485	101	7	-	-	HYPH
en-wikipedia-org-3485	101	8	stimulation	stimulation	NN
en-wikipedia-org-3485	101	9	electrodes	electrode	NNS
en-wikipedia-org-3485	101	10	in	in	IN
en-wikipedia-org-3485	101	11	the	the	DT
en-wikipedia-org-3485	101	12	lateral	lateral	JJ
en-wikipedia-org-3485	101	13	hypothalamus	hypothalamus	NN
en-wikipedia-org-3485	101	14	of	of	IN
en-wikipedia-org-3485	101	15	rats	rat	NNS
en-wikipedia-org-3485	101	16	increase	increase	VBP
en-wikipedia-org-3485	101	17	appetite	appetite	NN
en-wikipedia-org-3485	101	18	,	,	,
en-wikipedia-org-3485	101	19	but	but	CC
en-wikipedia-org-3485	101	20	also	also	RB
en-wikipedia-org-3485	101	21	cause	cause	VB
en-wikipedia-org-3485	101	22	more	more	JJR
en-wikipedia-org-3485	101	23	adverse	adverse	JJ
en-wikipedia-org-3485	101	24	reactions	reaction	NNS
en-wikipedia-org-3485	101	25	to	to	IN
en-wikipedia-org-3485	101	26	tastes	taste	NNS
en-wikipedia-org-3485	101	27	such	such	JJ
en-wikipedia-org-3485	101	28	as	as	IN
en-wikipedia-org-3485	101	29	sugar	sugar	NN
en-wikipedia-org-3485	101	30	and	and	CC
en-wikipedia-org-3485	101	31	salt	salt	NN
en-wikipedia-org-3485	101	32	;	;	:
en-wikipedia-org-3485	101	33	apparently	apparently	RB
en-wikipedia-org-3485	101	34	,	,	,
en-wikipedia-org-3485	101	35	the	the	DT
en-wikipedia-org-3485	101	36	stimulation	stimulation	NN
en-wikipedia-org-3485	101	37	increases	increase	VBZ
en-wikipedia-org-3485	101	38	wanting	want	VBG
en-wikipedia-org-3485	101	39	but	but	CC
en-wikipedia-org-3485	101	40	not	not	RB
en-wikipedia-org-3485	101	41	liking	like	VBG
en-wikipedia-org-3485	101	42	.	.	.
en-wikipedia-org-3485	102	1	Such	such	JJ
en-wikipedia-org-3485	102	2	results	result	NNS
en-wikipedia-org-3485	102	3	demonstrate	demonstrate	VBP
en-wikipedia-org-3485	102	4	that	that	IN
en-wikipedia-org-3485	102	5	the	the	DT
en-wikipedia-org-3485	102	6	reward	reward	NN
en-wikipedia-org-3485	102	7	system	system	NN
en-wikipedia-org-3485	102	8	of	of	IN
en-wikipedia-org-3485	102	9	rats	rat	NNS
en-wikipedia-org-3485	102	10	includes	include	VBZ
en-wikipedia-org-3485	102	11	independent	independent	JJ
en-wikipedia-org-3485	102	12	processes	process	NNS
en-wikipedia-org-3485	102	13	of	of	IN
en-wikipedia-org-3485	102	14	wanting	want	VBG
en-wikipedia-org-3485	102	15	and	and	CC
en-wikipedia-org-3485	102	16	liking	like	VBG
en-wikipedia-org-3485	102	17	.	.	.
en-wikipedia-org-3485	103	1	The	the	DT
en-wikipedia-org-3485	103	2	wanting	want	VBG
en-wikipedia-org-3485	103	3	component	component	NN
en-wikipedia-org-3485	103	4	is	be	VBZ
en-wikipedia-org-3485	103	5	thought	think	VBN
en-wikipedia-org-3485	103	6	to	to	TO
en-wikipedia-org-3485	103	7	be	be	VB
en-wikipedia-org-3485	103	8	controlled	control	VBN
en-wikipedia-org-3485	103	9	by	by	IN
en-wikipedia-org-3485	103	10	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	103	11	pathways	pathway	NNS
en-wikipedia-org-3485	103	12	,	,	,
en-wikipedia-org-3485	103	13	whereas	whereas	IN
en-wikipedia-org-3485	103	14	the	the	DT
en-wikipedia-org-3485	103	15	liking	like	VBG
en-wikipedia-org-3485	103	16	component	component	NN
en-wikipedia-org-3485	103	17	is	be	VBZ
en-wikipedia-org-3485	103	18	thought	think	VBN
en-wikipedia-org-3485	103	19	to	to	TO
en-wikipedia-org-3485	103	20	be	be	VB
en-wikipedia-org-3485	103	21	controlled	control	VBN
en-wikipedia-org-3485	103	22	by	by	IN
en-wikipedia-org-3485	103	23	opiate	opiate	JJ
en-wikipedia-org-3485	103	24	-	-	HYPH
en-wikipedia-org-3485	103	25	benzodiazepine	benzodiazepine	NN
en-wikipedia-org-3485	103	26	systems	system	NNS
en-wikipedia-org-3485	103	27	.	.	.
en-wikipedia-org-3485	104	1	[	[	-LRB-
en-wikipedia-org-3485	104	2	8	8	CD
en-wikipedia-org-3485	104	3	]	]	-RRB-
en-wikipedia-org-3485	104	4	Anti	Anti	NNP
en-wikipedia-org-3485	104	5	-	-	NNP
en-wikipedia-org-3485	104	6	Reward	Reward	NNP
en-wikipedia-org-3485	104	7	system[edit	system[edit	ADD
en-wikipedia-org-3485	104	8	]	]	-RRB-
en-wikipedia-org-3485	104	9	Koobs	Koobs	NNP
en-wikipedia-org-3485	104	10	&	&	CC
en-wikipedia-org-3485	104	11	LeMoal	LeMoal	NNP
en-wikipedia-org-3485	104	12	proposed	propose	VBD
en-wikipedia-org-3485	104	13	that	that	IN
en-wikipedia-org-3485	104	14	there	there	EX
en-wikipedia-org-3485	104	15	exists	exist	VBZ
en-wikipedia-org-3485	104	16	a	a	DT
en-wikipedia-org-3485	104	17	separate	separate	JJ
en-wikipedia-org-3485	104	18	circuit	circuit	NN
en-wikipedia-org-3485	104	19	responsible	responsible	JJ
en-wikipedia-org-3485	104	20	for	for	IN
en-wikipedia-org-3485	104	21	the	the	DT
en-wikipedia-org-3485	104	22	attenuation	attenuation	NN
en-wikipedia-org-3485	104	23	of	of	IN
en-wikipedia-org-3485	104	24	reward	reward	NN
en-wikipedia-org-3485	104	25	-	-	HYPH
en-wikipedia-org-3485	104	26	pursuing	pursue	VBG
en-wikipedia-org-3485	104	27	behavior	behavior	NN
en-wikipedia-org-3485	104	28	,	,	,
en-wikipedia-org-3485	104	29	which	which	WDT
en-wikipedia-org-3485	104	30	they	-PRON-	PRP
en-wikipedia-org-3485	104	31	termed	term	VBD
en-wikipedia-org-3485	104	32	the	the	DT
en-wikipedia-org-3485	104	33	anti	anti	JJ
en-wikipedia-org-3485	104	34	-	-	JJ
en-wikipedia-org-3485	104	35	reward	reward	JJ
en-wikipedia-org-3485	104	36	circuit	circuit	NN
en-wikipedia-org-3485	104	37	.	.	.
en-wikipedia-org-3485	105	1	This	this	DT
en-wikipedia-org-3485	105	2	component	component	NN
en-wikipedia-org-3485	105	3	acts	act	VBZ
en-wikipedia-org-3485	105	4	as	as	IN
en-wikipedia-org-3485	105	5	brakes	brake	NNS
en-wikipedia-org-3485	105	6	on	on	IN
en-wikipedia-org-3485	105	7	the	the	DT
en-wikipedia-org-3485	105	8	reward	reward	NN
en-wikipedia-org-3485	105	9	circuit	circuit	NN
en-wikipedia-org-3485	105	10	,	,	,
en-wikipedia-org-3485	105	11	thus	thus	RB
en-wikipedia-org-3485	105	12	preventing	prevent	VBG
en-wikipedia-org-3485	105	13	the	the	DT
en-wikipedia-org-3485	105	14	over	over	JJ
en-wikipedia-org-3485	105	15	pursuit	pursuit	NN
en-wikipedia-org-3485	105	16	of	of	IN
en-wikipedia-org-3485	105	17	food	food	NN
en-wikipedia-org-3485	105	18	,	,	,
en-wikipedia-org-3485	105	19	sex	sex	NN
en-wikipedia-org-3485	105	20	,	,	,
en-wikipedia-org-3485	105	21	etc	etc	FW
en-wikipedia-org-3485	105	22	.	.	.
en-wikipedia-org-3485	106	1	This	this	DT
en-wikipedia-org-3485	106	2	circuit	circuit	NN
en-wikipedia-org-3485	106	3	involves	involve	VBZ
en-wikipedia-org-3485	106	4	multiple	multiple	JJ
en-wikipedia-org-3485	106	5	parts	part	NNS
en-wikipedia-org-3485	106	6	of	of	IN
en-wikipedia-org-3485	106	7	the	the	DT
en-wikipedia-org-3485	106	8	amygdala	amygdala	NNP
en-wikipedia-org-3485	106	9	(	(	-LRB-
en-wikipedia-org-3485	106	10	the	the	DT
en-wikipedia-org-3485	106	11	bed	bed	NN
en-wikipedia-org-3485	106	12	nucleus	nucleus	NNP
en-wikipedia-org-3485	106	13	of	of	IN
en-wikipedia-org-3485	106	14	the	the	DT
en-wikipedia-org-3485	106	15	stria	stria	NNP
en-wikipedia-org-3485	106	16	terminalis	terminalis	NNP
en-wikipedia-org-3485	106	17	,	,	,
en-wikipedia-org-3485	106	18	the	the	DT
en-wikipedia-org-3485	106	19	central	central	JJ
en-wikipedia-org-3485	106	20	nucleus	nucleus	NNP
en-wikipedia-org-3485	106	21	)	)	-RRB-
en-wikipedia-org-3485	106	22	,	,	,
en-wikipedia-org-3485	106	23	the	the	DT
en-wikipedia-org-3485	106	24	Nucleus	Nucleus	NNP
en-wikipedia-org-3485	106	25	Accumbens	Accumbens	NNPS
en-wikipedia-org-3485	106	26	,	,	,
en-wikipedia-org-3485	106	27	and	and	CC
en-wikipedia-org-3485	106	28	signal	signal	NN
en-wikipedia-org-3485	106	29	molecules	molecule	NNS
en-wikipedia-org-3485	106	30	including	include	VBG
en-wikipedia-org-3485	106	31	norepinephrine	norepinephrine	NN
en-wikipedia-org-3485	106	32	,	,	,
en-wikipedia-org-3485	106	33	corticotropin	corticotropin	NN
en-wikipedia-org-3485	106	34	-	-	HYPH
en-wikipedia-org-3485	106	35	releasing	release	VBG
en-wikipedia-org-3485	106	36	factor	factor	NN
en-wikipedia-org-3485	106	37	,	,	,
en-wikipedia-org-3485	106	38	and	and	CC
en-wikipedia-org-3485	106	39	dynorphin	dynorphin	VB
en-wikipedia-org-3485	106	40	.	.	.
en-wikipedia-org-3485	107	1	[	[	-LRB-
en-wikipedia-org-3485	107	2	54	54	CD
en-wikipedia-org-3485	107	3	]	]	-RRB-
en-wikipedia-org-3485	107	4	This	this	DT
en-wikipedia-org-3485	107	5	circuit	circuit	NN
en-wikipedia-org-3485	107	6	is	be	VBZ
en-wikipedia-org-3485	107	7	also	also	RB
en-wikipedia-org-3485	107	8	hypothesized	hypothesize	VBN
en-wikipedia-org-3485	107	9	to	to	TO
en-wikipedia-org-3485	107	10	mediate	mediate	VB
en-wikipedia-org-3485	107	11	the	the	DT
en-wikipedia-org-3485	107	12	unpleasant	unpleasant	JJ
en-wikipedia-org-3485	107	13	components	component	NNS
en-wikipedia-org-3485	107	14	of	of	IN
en-wikipedia-org-3485	107	15	stress	stress	NN
en-wikipedia-org-3485	107	16	,	,	,
en-wikipedia-org-3485	107	17	and	and	CC
en-wikipedia-org-3485	107	18	is	be	VBZ
en-wikipedia-org-3485	107	19	thus	thus	RB
en-wikipedia-org-3485	107	20	thought	think	VBN
en-wikipedia-org-3485	107	21	to	to	TO
en-wikipedia-org-3485	107	22	be	be	VB
en-wikipedia-org-3485	107	23	involved	involve	VBN
en-wikipedia-org-3485	107	24	in	in	IN
en-wikipedia-org-3485	107	25	addiction	addiction	NN
en-wikipedia-org-3485	107	26	and	and	CC
en-wikipedia-org-3485	107	27	withdrawal	withdrawal	NN
en-wikipedia-org-3485	107	28	.	.	.
en-wikipedia-org-3485	108	1	While	while	IN
en-wikipedia-org-3485	108	2	the	the	DT
en-wikipedia-org-3485	108	3	reward	reward	NN
en-wikipedia-org-3485	108	4	circuit	circuit	NN
en-wikipedia-org-3485	108	5	mediates	mediate	VBZ
en-wikipedia-org-3485	108	6	the	the	DT
en-wikipedia-org-3485	108	7	initial	initial	JJ
en-wikipedia-org-3485	108	8	positive	positive	JJ
en-wikipedia-org-3485	108	9	reinforcement	reinforcement	NN
en-wikipedia-org-3485	108	10	involved	involve	VBN
en-wikipedia-org-3485	108	11	in	in	IN
en-wikipedia-org-3485	108	12	the	the	DT
en-wikipedia-org-3485	108	13	development	development	NN
en-wikipedia-org-3485	108	14	of	of	IN
en-wikipedia-org-3485	108	15	addiction	addiction	NN
en-wikipedia-org-3485	108	16	,	,	,
en-wikipedia-org-3485	108	17	it	-PRON-	PRP
en-wikipedia-org-3485	108	18	is	be	VBZ
en-wikipedia-org-3485	108	19	the	the	DT
en-wikipedia-org-3485	108	20	anti	anti	JJ
en-wikipedia-org-3485	108	21	-	-	JJ
en-wikipedia-org-3485	108	22	reward	reward	JJ
en-wikipedia-org-3485	108	23	circuit	circuit	NN
en-wikipedia-org-3485	108	24	that	that	WDT
en-wikipedia-org-3485	108	25	later	later	RB
en-wikipedia-org-3485	108	26	dominates	dominate	VBZ
en-wikipedia-org-3485	108	27	via	via	IN
en-wikipedia-org-3485	108	28	negative	negative	JJ
en-wikipedia-org-3485	108	29	reinforcement	reinforcement	NN
en-wikipedia-org-3485	108	30	that	that	WDT
en-wikipedia-org-3485	108	31	motivates	motivate	VBZ
en-wikipedia-org-3485	108	32	the	the	DT
en-wikipedia-org-3485	108	33	pursuit	pursuit	NN
en-wikipedia-org-3485	108	34	of	of	IN
en-wikipedia-org-3485	108	35	the	the	DT
en-wikipedia-org-3485	108	36	rewarding	rewarding	JJ
en-wikipedia-org-3485	108	37	stimuli	stimulus	NNS
en-wikipedia-org-3485	108	38	.	.	.
en-wikipedia-org-3485	109	1	[	[	-LRB-
en-wikipedia-org-3485	109	2	55	55	CD
en-wikipedia-org-3485	109	3	]	]	-RRB-
en-wikipedia-org-3485	109	4	Learning[edit	learning[edit	NN
en-wikipedia-org-3485	109	5	]	]	-RRB-
en-wikipedia-org-3485	109	6	Further	further	JJ
en-wikipedia-org-3485	109	7	information	information	NN
en-wikipedia-org-3485	109	8	:	:	:
en-wikipedia-org-3485	109	9	Associative	associative	JJ
en-wikipedia-org-3485	109	10	learning	learn	VBG
en-wikipedia-org-3485	109	11	Rewarding	Rewarding	NNP
en-wikipedia-org-3485	109	12	stimuli	stimulus	NNS
en-wikipedia-org-3485	109	13	can	can	MD
en-wikipedia-org-3485	109	14	drive	drive	VB
en-wikipedia-org-3485	109	15	learning	learn	VBG
en-wikipedia-org-3485	109	16	in	in	IN
en-wikipedia-org-3485	109	17	both	both	DT
en-wikipedia-org-3485	109	18	the	the	DT
en-wikipedia-org-3485	109	19	form	form	NN
en-wikipedia-org-3485	109	20	of	of	IN
en-wikipedia-org-3485	109	21	classical	classical	JJ
en-wikipedia-org-3485	109	22	conditioning	conditioning	NN
en-wikipedia-org-3485	109	23	(	(	-LRB-
en-wikipedia-org-3485	109	24	Pavlovian	pavlovian	JJ
en-wikipedia-org-3485	109	25	conditioning	conditioning	NN
en-wikipedia-org-3485	109	26	)	)	-RRB-
en-wikipedia-org-3485	109	27	and	and	CC
en-wikipedia-org-3485	109	28	operant	operant	JJ
en-wikipedia-org-3485	109	29	conditioning	conditioning	NN
en-wikipedia-org-3485	109	30	(	(	-LRB-
en-wikipedia-org-3485	109	31	instrumental	instrumental	JJ
en-wikipedia-org-3485	109	32	conditioning	conditioning	NN
en-wikipedia-org-3485	109	33	)	)	-RRB-
en-wikipedia-org-3485	109	34	.	.	.
en-wikipedia-org-3485	110	1	In	in	IN
en-wikipedia-org-3485	110	2	classical	classical	JJ
en-wikipedia-org-3485	110	3	conditioning	conditioning	NN
en-wikipedia-org-3485	110	4	,	,	,
en-wikipedia-org-3485	110	5	a	a	DT
en-wikipedia-org-3485	110	6	reward	reward	NN
en-wikipedia-org-3485	110	7	can	can	MD
en-wikipedia-org-3485	110	8	act	act	VB
en-wikipedia-org-3485	110	9	as	as	IN
en-wikipedia-org-3485	110	10	an	an	DT
en-wikipedia-org-3485	110	11	unconditioned	unconditioned	JJ
en-wikipedia-org-3485	110	12	stimulus	stimulus	NN
en-wikipedia-org-3485	110	13	that	that	WDT
en-wikipedia-org-3485	110	14	,	,	,
en-wikipedia-org-3485	110	15	when	when	WRB
en-wikipedia-org-3485	110	16	associated	associate	VBN
en-wikipedia-org-3485	110	17	with	with	IN
en-wikipedia-org-3485	110	18	the	the	DT
en-wikipedia-org-3485	110	19	conditioned	condition	VBN
en-wikipedia-org-3485	110	20	stimulus	stimulus	NN
en-wikipedia-org-3485	110	21	,	,	,
en-wikipedia-org-3485	110	22	causes	cause	VBZ
en-wikipedia-org-3485	110	23	the	the	DT
en-wikipedia-org-3485	110	24	conditioned	condition	VBN
en-wikipedia-org-3485	110	25	stimulus	stimulus	NN
en-wikipedia-org-3485	110	26	to	to	IN
en-wikipedia-org-3485	110	27	elicit	elicit	NN
en-wikipedia-org-3485	110	28	both	both	DT
en-wikipedia-org-3485	110	29	musculoskeletal	musculoskeletal	JJ
en-wikipedia-org-3485	110	30	(	(	-LRB-
en-wikipedia-org-3485	110	31	in	in	IN
en-wikipedia-org-3485	110	32	the	the	DT
en-wikipedia-org-3485	110	33	form	form	NN
en-wikipedia-org-3485	110	34	of	of	IN
en-wikipedia-org-3485	110	35	simple	simple	JJ
en-wikipedia-org-3485	110	36	approach	approach	NN
en-wikipedia-org-3485	110	37	and	and	CC
en-wikipedia-org-3485	110	38	avoidance	avoidance	NN
en-wikipedia-org-3485	110	39	behaviors	behavior	NNS
en-wikipedia-org-3485	110	40	)	)	-RRB-
en-wikipedia-org-3485	110	41	and	and	CC
en-wikipedia-org-3485	110	42	vegetative	vegetative	JJ
en-wikipedia-org-3485	110	43	responses	response	NNS
en-wikipedia-org-3485	110	44	.	.	.
en-wikipedia-org-3485	111	1	In	in	IN
en-wikipedia-org-3485	111	2	operant	operant	JJ
en-wikipedia-org-3485	111	3	conditioning	conditioning	NN
en-wikipedia-org-3485	111	4	,	,	,
en-wikipedia-org-3485	111	5	a	a	DT
en-wikipedia-org-3485	111	6	reward	reward	NN
en-wikipedia-org-3485	111	7	may	may	MD
en-wikipedia-org-3485	111	8	act	act	VB
en-wikipedia-org-3485	111	9	as	as	IN
en-wikipedia-org-3485	111	10	a	a	DT
en-wikipedia-org-3485	111	11	reinforcer	reinforcer	NN
en-wikipedia-org-3485	111	12	in	in	IN
en-wikipedia-org-3485	111	13	that	that	IN
en-wikipedia-org-3485	111	14	it	-PRON-	PRP
en-wikipedia-org-3485	111	15	increases	increase	VBZ
en-wikipedia-org-3485	111	16	or	or	CC
en-wikipedia-org-3485	111	17	supports	support	VBZ
en-wikipedia-org-3485	111	18	actions	action	NNS
en-wikipedia-org-3485	111	19	that	that	WDT
en-wikipedia-org-3485	111	20	lead	lead	VBP
en-wikipedia-org-3485	111	21	to	to	IN
en-wikipedia-org-3485	111	22	itself	-PRON-	PRP
en-wikipedia-org-3485	111	23	.	.	.
en-wikipedia-org-3485	112	1	[	[	-LRB-
en-wikipedia-org-3485	112	2	3	3	LS
en-wikipedia-org-3485	112	3	]	]	-RRB-
en-wikipedia-org-3485	112	4	Learned	learn	VBN
en-wikipedia-org-3485	112	5	behaviors	behavior	NNS
en-wikipedia-org-3485	112	6	may	may	MD
en-wikipedia-org-3485	112	7	or	or	CC
en-wikipedia-org-3485	112	8	may	may	MD
en-wikipedia-org-3485	112	9	not	not	RB
en-wikipedia-org-3485	112	10	be	be	VB
en-wikipedia-org-3485	112	11	sensitive	sensitive	JJ
en-wikipedia-org-3485	112	12	to	to	IN
en-wikipedia-org-3485	112	13	the	the	DT
en-wikipedia-org-3485	112	14	value	value	NN
en-wikipedia-org-3485	112	15	of	of	IN
en-wikipedia-org-3485	112	16	the	the	DT
en-wikipedia-org-3485	112	17	outcomes	outcome	NNS
en-wikipedia-org-3485	112	18	they	-PRON-	PRP
en-wikipedia-org-3485	112	19	lead	lead	VBP
en-wikipedia-org-3485	112	20	to	to	IN
en-wikipedia-org-3485	112	21	;	;	:
en-wikipedia-org-3485	112	22	behaviors	behavior	NNS
en-wikipedia-org-3485	112	23	that	that	WDT
en-wikipedia-org-3485	112	24	are	be	VBP
en-wikipedia-org-3485	112	25	sensitive	sensitive	JJ
en-wikipedia-org-3485	112	26	to	to	IN
en-wikipedia-org-3485	112	27	the	the	DT
en-wikipedia-org-3485	112	28	contingency	contingency	NN
en-wikipedia-org-3485	112	29	of	of	IN
en-wikipedia-org-3485	112	30	an	an	DT
en-wikipedia-org-3485	112	31	outcome	outcome	NN
en-wikipedia-org-3485	112	32	on	on	IN
en-wikipedia-org-3485	112	33	the	the	DT
en-wikipedia-org-3485	112	34	performance	performance	NN
en-wikipedia-org-3485	112	35	of	of	IN
en-wikipedia-org-3485	112	36	an	an	DT
en-wikipedia-org-3485	112	37	action	action	NN
en-wikipedia-org-3485	112	38	as	as	RB
en-wikipedia-org-3485	112	39	well	well	RB
en-wikipedia-org-3485	112	40	as	as	IN
en-wikipedia-org-3485	112	41	the	the	DT
en-wikipedia-org-3485	112	42	outcome	outcome	NN
en-wikipedia-org-3485	112	43	value	value	NN
en-wikipedia-org-3485	112	44	are	be	VBP
en-wikipedia-org-3485	112	45	goal	goal	NN
en-wikipedia-org-3485	112	46	-	-	HYPH
en-wikipedia-org-3485	112	47	directed	direct	VBN
en-wikipedia-org-3485	112	48	,	,	,
en-wikipedia-org-3485	112	49	while	while	IN
en-wikipedia-org-3485	112	50	elicited	elicit	VBN
en-wikipedia-org-3485	112	51	actions	action	NNS
en-wikipedia-org-3485	112	52	that	that	WDT
en-wikipedia-org-3485	112	53	are	be	VBP
en-wikipedia-org-3485	112	54	insensitive	insensitive	JJ
en-wikipedia-org-3485	112	55	to	to	IN
en-wikipedia-org-3485	112	56	contingency	contingency	NN
en-wikipedia-org-3485	112	57	or	or	CC
en-wikipedia-org-3485	112	58	value	value	NN
en-wikipedia-org-3485	112	59	are	be	VBP
en-wikipedia-org-3485	112	60	called	call	VBN
en-wikipedia-org-3485	112	61	habits	habit	NNS
en-wikipedia-org-3485	112	62	.	.	.
en-wikipedia-org-3485	113	1	[	[	-LRB-
en-wikipedia-org-3485	113	2	56	56	CD
en-wikipedia-org-3485	113	3	]	]	-RRB-
en-wikipedia-org-3485	113	4	This	this	DT
en-wikipedia-org-3485	113	5	distinction	distinction	NN
en-wikipedia-org-3485	113	6	is	be	VBZ
en-wikipedia-org-3485	113	7	thought	think	VBN
en-wikipedia-org-3485	113	8	to	to	TO
en-wikipedia-org-3485	113	9	reflected	reflect	VBN
en-wikipedia-org-3485	113	10	two	two	CD
en-wikipedia-org-3485	113	11	forms	form	NNS
en-wikipedia-org-3485	113	12	of	of	IN
en-wikipedia-org-3485	113	13	learning	learning	NN
en-wikipedia-org-3485	113	14	,	,	,
en-wikipedia-org-3485	113	15	model	model	NN
en-wikipedia-org-3485	113	16	free	free	JJ
en-wikipedia-org-3485	113	17	and	and	CC
en-wikipedia-org-3485	113	18	model	model	NN
en-wikipedia-org-3485	113	19	based	base	VBN
en-wikipedia-org-3485	113	20	.	.	.
en-wikipedia-org-3485	114	1	Model	model	JJ
en-wikipedia-org-3485	114	2	free	free	JJ
en-wikipedia-org-3485	114	3	learning	learning	NN
en-wikipedia-org-3485	114	4	involves	involve	VBZ
en-wikipedia-org-3485	114	5	the	the	DT
en-wikipedia-org-3485	114	6	simple	simple	JJ
en-wikipedia-org-3485	114	7	caching	caching	NN
en-wikipedia-org-3485	114	8	and	and	CC
en-wikipedia-org-3485	114	9	updating	updating	NN
en-wikipedia-org-3485	114	10	of	of	IN
en-wikipedia-org-3485	114	11	values	value	NNS
en-wikipedia-org-3485	114	12	.	.	.
en-wikipedia-org-3485	115	1	In	in	IN
en-wikipedia-org-3485	115	2	contrast	contrast	NN
en-wikipedia-org-3485	115	3	,	,	,
en-wikipedia-org-3485	115	4	model	model	NN
en-wikipedia-org-3485	115	5	based	base	VBN
en-wikipedia-org-3485	115	6	learning	learning	NN
en-wikipedia-org-3485	115	7	involves	involve	VBZ
en-wikipedia-org-3485	115	8	the	the	DT
en-wikipedia-org-3485	115	9	storage	storage	NN
en-wikipedia-org-3485	115	10	and	and	CC
en-wikipedia-org-3485	115	11	construction	construction	NN
en-wikipedia-org-3485	115	12	of	of	IN
en-wikipedia-org-3485	115	13	an	an	DT
en-wikipedia-org-3485	115	14	internal	internal	JJ
en-wikipedia-org-3485	115	15	model	model	NN
en-wikipedia-org-3485	115	16	of	of	IN
en-wikipedia-org-3485	115	17	events	event	NNS
en-wikipedia-org-3485	115	18	that	that	WDT
en-wikipedia-org-3485	115	19	allows	allow	VBZ
en-wikipedia-org-3485	115	20	inference	inference	NN
en-wikipedia-org-3485	115	21	and	and	CC
en-wikipedia-org-3485	115	22	flexible	flexible	JJ
en-wikipedia-org-3485	115	23	prediction	prediction	NN
en-wikipedia-org-3485	115	24	.	.	.
en-wikipedia-org-3485	116	1	Although	although	IN
en-wikipedia-org-3485	116	2	pavlovian	pavlovian	JJ
en-wikipedia-org-3485	116	3	conditioning	conditioning	NN
en-wikipedia-org-3485	116	4	is	be	VBZ
en-wikipedia-org-3485	116	5	generally	generally	RB
en-wikipedia-org-3485	116	6	assumed	assume	VBN
en-wikipedia-org-3485	116	7	to	to	TO
en-wikipedia-org-3485	116	8	be	be	VB
en-wikipedia-org-3485	116	9	model	model	NN
en-wikipedia-org-3485	116	10	-	-	HYPH
en-wikipedia-org-3485	116	11	free	free	JJ
en-wikipedia-org-3485	116	12	,	,	,
en-wikipedia-org-3485	116	13	the	the	DT
en-wikipedia-org-3485	116	14	incentive	incentive	NN
en-wikipedia-org-3485	116	15	salience	salience	NN
en-wikipedia-org-3485	116	16	assigned	assign	VBN
en-wikipedia-org-3485	116	17	to	to	IN
en-wikipedia-org-3485	116	18	a	a	DT
en-wikipedia-org-3485	116	19	conditioned	condition	VBN
en-wikipedia-org-3485	116	20	stimulus	stimulus	NN
en-wikipedia-org-3485	116	21	is	be	VBZ
en-wikipedia-org-3485	116	22	flexible	flexible	JJ
en-wikipedia-org-3485	116	23	with	with	IN
en-wikipedia-org-3485	116	24	regard	regard	NN
en-wikipedia-org-3485	116	25	to	to	IN
en-wikipedia-org-3485	116	26	changes	change	NNS
en-wikipedia-org-3485	116	27	in	in	IN
en-wikipedia-org-3485	116	28	internal	internal	JJ
en-wikipedia-org-3485	116	29	motivational	motivational	JJ
en-wikipedia-org-3485	116	30	states	state	NNS
en-wikipedia-org-3485	116	31	.	.	.
en-wikipedia-org-3485	117	1	[	[	-LRB-
en-wikipedia-org-3485	117	2	57	57	CD
en-wikipedia-org-3485	117	3	]	]	-RRB-
en-wikipedia-org-3485	117	4	Distinct	distinct	JJ
en-wikipedia-org-3485	117	5	neural	neural	JJ
en-wikipedia-org-3485	117	6	systems	system	NNS
en-wikipedia-org-3485	117	7	are	be	VBP
en-wikipedia-org-3485	117	8	responsible	responsible	JJ
en-wikipedia-org-3485	117	9	for	for	IN
en-wikipedia-org-3485	117	10	learning	learn	VBG
en-wikipedia-org-3485	117	11	associations	association	NNS
en-wikipedia-org-3485	117	12	between	between	IN
en-wikipedia-org-3485	117	13	stimuli	stimulus	NNS
en-wikipedia-org-3485	117	14	and	and	CC
en-wikipedia-org-3485	117	15	outcomes	outcome	NNS
en-wikipedia-org-3485	117	16	,	,	,
en-wikipedia-org-3485	117	17	actions	action	NNS
en-wikipedia-org-3485	117	18	and	and	CC
en-wikipedia-org-3485	117	19	outcomes	outcome	NNS
en-wikipedia-org-3485	117	20	,	,	,
en-wikipedia-org-3485	117	21	and	and	CC
en-wikipedia-org-3485	117	22	stimuli	stimulus	NNS
en-wikipedia-org-3485	117	23	and	and	CC
en-wikipedia-org-3485	117	24	responses	response	NNS
en-wikipedia-org-3485	117	25	.	.	.
en-wikipedia-org-3485	118	1	Although	although	IN
en-wikipedia-org-3485	118	2	classical	classical	JJ
en-wikipedia-org-3485	118	3	conditioning	conditioning	NN
en-wikipedia-org-3485	118	4	is	be	VBZ
en-wikipedia-org-3485	118	5	not	not	RB
en-wikipedia-org-3485	118	6	limited	limit	VBN
en-wikipedia-org-3485	118	7	to	to	IN
en-wikipedia-org-3485	118	8	the	the	DT
en-wikipedia-org-3485	118	9	reward	reward	NN
en-wikipedia-org-3485	118	10	system	system	NN
en-wikipedia-org-3485	118	11	,	,	,
en-wikipedia-org-3485	118	12	the	the	DT
en-wikipedia-org-3485	118	13	enhancement	enhancement	NN
en-wikipedia-org-3485	118	14	of	of	IN
en-wikipedia-org-3485	118	15	instrumental	instrumental	JJ
en-wikipedia-org-3485	118	16	performance	performance	NN
en-wikipedia-org-3485	118	17	by	by	IN
en-wikipedia-org-3485	118	18	stimuli	stimulus	NNS
en-wikipedia-org-3485	118	19	(	(	-LRB-
en-wikipedia-org-3485	118	20	i.e.	i.e.	FW
en-wikipedia-org-3485	118	21	,	,	,
en-wikipedia-org-3485	118	22	Pavlovian	Pavlovian	NNP
en-wikipedia-org-3485	118	23	-	-	HYPH
en-wikipedia-org-3485	118	24	instrumental	instrumental	JJ
en-wikipedia-org-3485	118	25	transfer	transfer	NN
en-wikipedia-org-3485	118	26	)	)	-RRB-
en-wikipedia-org-3485	118	27	requires	require	VBZ
en-wikipedia-org-3485	118	28	the	the	DT
en-wikipedia-org-3485	118	29	nucleus	nucleus	NN
en-wikipedia-org-3485	118	30	accumbens	accumben	NNS
en-wikipedia-org-3485	118	31	.	.	.
en-wikipedia-org-3485	119	1	Habitual	habitual	JJ
en-wikipedia-org-3485	119	2	and	and	CC
en-wikipedia-org-3485	119	3	goal	goal	NN
en-wikipedia-org-3485	119	4	directed	direct	VBD
en-wikipedia-org-3485	119	5	instrumental	instrumental	JJ
en-wikipedia-org-3485	119	6	learning	learning	NN
en-wikipedia-org-3485	119	7	are	be	VBP
en-wikipedia-org-3485	119	8	dependent	dependent	JJ
en-wikipedia-org-3485	119	9	upon	upon	IN
en-wikipedia-org-3485	119	10	the	the	DT
en-wikipedia-org-3485	119	11	lateral	lateral	JJ
en-wikipedia-org-3485	119	12	striatum	striatum	NN
en-wikipedia-org-3485	119	13	and	and	CC
en-wikipedia-org-3485	119	14	the	the	DT
en-wikipedia-org-3485	119	15	medial	medial	JJ
en-wikipedia-org-3485	119	16	striatum	striatum	NN
en-wikipedia-org-3485	119	17	,	,	,
en-wikipedia-org-3485	119	18	respectively	respectively	RB
en-wikipedia-org-3485	119	19	.	.	.
en-wikipedia-org-3485	120	1	[	[	-LRB-
en-wikipedia-org-3485	120	2	56	56	CD
en-wikipedia-org-3485	120	3	]	]	-RRB-
en-wikipedia-org-3485	120	4	During	during	IN
en-wikipedia-org-3485	120	5	instrumental	instrumental	JJ
en-wikipedia-org-3485	120	6	learning	learning	NN
en-wikipedia-org-3485	120	7	,	,	,
en-wikipedia-org-3485	120	8	opposing	oppose	VBG
en-wikipedia-org-3485	120	9	changes	change	NNS
en-wikipedia-org-3485	120	10	in	in	IN
en-wikipedia-org-3485	120	11	the	the	DT
en-wikipedia-org-3485	120	12	ratio	ratio	NN
en-wikipedia-org-3485	120	13	of	of	IN
en-wikipedia-org-3485	120	14	AMPA	AMPA	NNS
en-wikipedia-org-3485	120	15	to	to	IN
en-wikipedia-org-3485	120	16	NMDA	NMDA	NNP
en-wikipedia-org-3485	120	17	receptors	receptor	NNS
en-wikipedia-org-3485	120	18	and	and	CC
en-wikipedia-org-3485	120	19	phosphorylated	phosphorylate	VBD
en-wikipedia-org-3485	120	20	ERK	ERK	NNP
en-wikipedia-org-3485	120	21	occurs	occur	NNS
en-wikipedia-org-3485	120	22	in	in	IN
en-wikipedia-org-3485	120	23	the	the	DT
en-wikipedia-org-3485	120	24	D1-type	D1-type	NNS
en-wikipedia-org-3485	120	25	and	and	CC
en-wikipedia-org-3485	120	26	D2-type	D2-type	NNP
en-wikipedia-org-3485	120	27	MSNs	msn	NNS
en-wikipedia-org-3485	120	28	that	that	WDT
en-wikipedia-org-3485	120	29	constitute	constitute	VBP
en-wikipedia-org-3485	120	30	the	the	DT
en-wikipedia-org-3485	120	31	direct	direct	JJ
en-wikipedia-org-3485	120	32	and	and	CC
en-wikipedia-org-3485	120	33	indirect	indirect	JJ
en-wikipedia-org-3485	120	34	pathways	pathway	NNS
en-wikipedia-org-3485	120	35	,	,	,
en-wikipedia-org-3485	120	36	respectively	respectively	RB
en-wikipedia-org-3485	120	37	.	.	.
en-wikipedia-org-3485	121	1	[	[	-LRB-
en-wikipedia-org-3485	121	2	58][59	58][59	CD
en-wikipedia-org-3485	121	3	]	]	-RRB-
en-wikipedia-org-3485	121	4	These	these	DT
en-wikipedia-org-3485	121	5	changes	change	NNS
en-wikipedia-org-3485	121	6	in	in	IN
en-wikipedia-org-3485	121	7	synaptic	synaptic	JJ
en-wikipedia-org-3485	121	8	plasticity	plasticity	NN
en-wikipedia-org-3485	121	9	and	and	CC
en-wikipedia-org-3485	121	10	the	the	DT
en-wikipedia-org-3485	121	11	accompanying	accompany	VBG
en-wikipedia-org-3485	121	12	learning	learning	NN
en-wikipedia-org-3485	121	13	is	be	VBZ
en-wikipedia-org-3485	121	14	dependent	dependent	JJ
en-wikipedia-org-3485	121	15	upon	upon	IN
en-wikipedia-org-3485	121	16	activation	activation	NN
en-wikipedia-org-3485	121	17	of	of	IN
en-wikipedia-org-3485	121	18	striatal	striatal	JJ
en-wikipedia-org-3485	121	19	D1	d1	NN
en-wikipedia-org-3485	121	20	and	and	CC
en-wikipedia-org-3485	121	21	NMDA	NMDA	NNP
en-wikipedia-org-3485	121	22	receptors	receptor	NNS
en-wikipedia-org-3485	121	23	.	.	.
en-wikipedia-org-3485	122	1	The	the	DT
en-wikipedia-org-3485	122	2	intracellular	intracellular	JJ
en-wikipedia-org-3485	122	3	cascade	cascade	NN
en-wikipedia-org-3485	122	4	activated	activate	VBN
en-wikipedia-org-3485	122	5	by	by	IN
en-wikipedia-org-3485	122	6	D1	d1	NN
en-wikipedia-org-3485	122	7	receptors	receptor	NNS
en-wikipedia-org-3485	122	8	involves	involve	VBZ
en-wikipedia-org-3485	122	9	the	the	DT
en-wikipedia-org-3485	122	10	recruitment	recruitment	NN
en-wikipedia-org-3485	122	11	of	of	IN
en-wikipedia-org-3485	122	12	protein	protein	NN
en-wikipedia-org-3485	122	13	kinase	kinase	VBD
en-wikipedia-org-3485	122	14	A	A	NNP
en-wikipedia-org-3485	122	15	,	,	,
en-wikipedia-org-3485	122	16	and	and	CC
en-wikipedia-org-3485	122	17	through	through	IN
en-wikipedia-org-3485	122	18	resulting	result	VBG
en-wikipedia-org-3485	122	19	phosphorylation	phosphorylation	NN
en-wikipedia-org-3485	122	20	of	of	IN
en-wikipedia-org-3485	122	21	DARPP-32	darpp-32	NN
en-wikipedia-org-3485	122	22	,	,	,
en-wikipedia-org-3485	122	23	the	the	DT
en-wikipedia-org-3485	122	24	inhibition	inhibition	NN
en-wikipedia-org-3485	122	25	of	of	IN
en-wikipedia-org-3485	122	26	phosphatases	phosphatase	NNS
en-wikipedia-org-3485	122	27	that	that	WDT
en-wikipedia-org-3485	122	28	deactivate	deactivate	VBP
en-wikipedia-org-3485	122	29	ERK	ERK	NNP
en-wikipedia-org-3485	122	30	.	.	.
en-wikipedia-org-3485	123	1	NMDA	nmda	NN
en-wikipedia-org-3485	123	2	receptors	receptor	NNS
en-wikipedia-org-3485	123	3	activate	activate	VBP
en-wikipedia-org-3485	123	4	ERK	ERK	NNP
en-wikipedia-org-3485	123	5	through	through	IN
en-wikipedia-org-3485	123	6	a	a	DT
en-wikipedia-org-3485	123	7	different	different	JJ
en-wikipedia-org-3485	123	8	but	but	CC
en-wikipedia-org-3485	123	9	interrelated	interrelate	VBD
en-wikipedia-org-3485	123	10	Ras	Ras	NNP
en-wikipedia-org-3485	123	11	-	-	HYPH
en-wikipedia-org-3485	123	12	Raf	Raf	NNP
en-wikipedia-org-3485	123	13	-	-	HYPH
en-wikipedia-org-3485	123	14	MEK	MEK	NNP
en-wikipedia-org-3485	123	15	-	-	HYPH
en-wikipedia-org-3485	123	16	ERK	ERK	NNP
en-wikipedia-org-3485	123	17	pathway	pathway	NN
en-wikipedia-org-3485	123	18	.	.	.
en-wikipedia-org-3485	124	1	Alone	alone	JJ
en-wikipedia-org-3485	124	2	NMDA	NMDA	NNP
en-wikipedia-org-3485	124	3	mediated	mediate	VBN
en-wikipedia-org-3485	124	4	activation	activation	NN
en-wikipedia-org-3485	124	5	of	of	IN
en-wikipedia-org-3485	124	6	ERK	ERK	NNP
en-wikipedia-org-3485	124	7	is	be	VBZ
en-wikipedia-org-3485	124	8	self	self	NN
en-wikipedia-org-3485	124	9	-	-	HYPH
en-wikipedia-org-3485	124	10	limited	limited	JJ
en-wikipedia-org-3485	124	11	,	,	,
en-wikipedia-org-3485	124	12	as	as	IN
en-wikipedia-org-3485	124	13	NMDA	NMDA	NNP
en-wikipedia-org-3485	124	14	activation	activation	NN
en-wikipedia-org-3485	124	15	also	also	RB
en-wikipedia-org-3485	124	16	inhibits	inhibit	VBZ
en-wikipedia-org-3485	124	17	PKA	PKA	NNP
en-wikipedia-org-3485	124	18	mediated	mediate	VBD
en-wikipedia-org-3485	124	19	inhibition	inhibition	NN
en-wikipedia-org-3485	124	20	of	of	IN
en-wikipedia-org-3485	124	21	ERK	ERK	NNP
en-wikipedia-org-3485	124	22	deactivating	deactivate	VBG
en-wikipedia-org-3485	124	23	phosphatases	phosphatase	NNS
en-wikipedia-org-3485	124	24	.	.	.
en-wikipedia-org-3485	125	1	However	however	RB
en-wikipedia-org-3485	125	2	,	,	,
en-wikipedia-org-3485	125	3	when	when	WRB
en-wikipedia-org-3485	125	4	D1	d1	NN
en-wikipedia-org-3485	125	5	and	and	CC
en-wikipedia-org-3485	125	6	NMDA	NMDA	NNP
en-wikipedia-org-3485	125	7	cascades	cascade	NNS
en-wikipedia-org-3485	125	8	are	be	VBP
en-wikipedia-org-3485	125	9	co	co	JJ
en-wikipedia-org-3485	125	10	-	-	VBN
en-wikipedia-org-3485	125	11	activated	activate	VBN
en-wikipedia-org-3485	125	12	,	,	,
en-wikipedia-org-3485	125	13	they	-PRON-	PRP
en-wikipedia-org-3485	125	14	work	work	VBP
en-wikipedia-org-3485	125	15	synergistically	synergistically	RB
en-wikipedia-org-3485	125	16	,	,	,
en-wikipedia-org-3485	125	17	and	and	CC
en-wikipedia-org-3485	125	18	the	the	DT
en-wikipedia-org-3485	125	19	resultant	resultant	JJ
en-wikipedia-org-3485	125	20	activation	activation	NN
en-wikipedia-org-3485	125	21	of	of	IN
en-wikipedia-org-3485	125	22	ERK	ERK	NNP
en-wikipedia-org-3485	125	23	regulates	regulate	VBZ
en-wikipedia-org-3485	125	24	synaptic	synaptic	JJ
en-wikipedia-org-3485	125	25	plasticity	plasticity	NN
en-wikipedia-org-3485	125	26	in	in	IN
en-wikipedia-org-3485	125	27	the	the	DT
en-wikipedia-org-3485	125	28	form	form	NN
en-wikipedia-org-3485	125	29	of	of	IN
en-wikipedia-org-3485	125	30	spine	spine	NN
en-wikipedia-org-3485	125	31	restructuring	restructuring	NN
en-wikipedia-org-3485	125	32	,	,	,
en-wikipedia-org-3485	125	33	transport	transport	NN
en-wikipedia-org-3485	125	34	of	of	IN
en-wikipedia-org-3485	125	35	AMPA	AMPA	NNP
en-wikipedia-org-3485	125	36	receptors	receptor	NNS
en-wikipedia-org-3485	125	37	,	,	,
en-wikipedia-org-3485	125	38	regulation	regulation	NN
en-wikipedia-org-3485	125	39	of	of	IN
en-wikipedia-org-3485	125	40	CREB	CREB	NNP
en-wikipedia-org-3485	125	41	,	,	,
en-wikipedia-org-3485	125	42	and	and	CC
en-wikipedia-org-3485	125	43	increasing	increase	VBG
en-wikipedia-org-3485	125	44	cellular	cellular	JJ
en-wikipedia-org-3485	125	45	excitability	excitability	NN
en-wikipedia-org-3485	125	46	via	via	IN
en-wikipedia-org-3485	125	47	inhibiting	inhibit	VBG
en-wikipedia-org-3485	125	48	Kv4.2[60][61][62	Kv4.2[60][61][62	NNP
en-wikipedia-org-3485	125	49	]	]	-RRB-
en-wikipedia-org-3485	125	50	Disorders[edit	disorders[edit	NN
en-wikipedia-org-3485	125	51	]	]	-RRB-
en-wikipedia-org-3485	125	52	Addiction[edit	Addiction[edit	``
en-wikipedia-org-3485	125	53	]	]	-RRB-
en-wikipedia-org-3485	125	54	Main	main	JJ
en-wikipedia-org-3485	125	55	article	article	NN
en-wikipedia-org-3485	125	56	:	:	:
en-wikipedia-org-3485	125	57	Addiction	addiction	NN
en-wikipedia-org-3485	125	58	ΔFosB	ΔFosB	VBZ
en-wikipedia-org-3485	125	59	(	(	-LRB-
en-wikipedia-org-3485	125	60	DeltaFosB	DeltaFosB	NNP
en-wikipedia-org-3485	125	61	)	)	-RRB-
en-wikipedia-org-3485	125	62	–	–	:
en-wikipedia-org-3485	125	63	a	a	DT
en-wikipedia-org-3485	125	64	gene	gene	NN
en-wikipedia-org-3485	125	65	transcription	transcription	NN
en-wikipedia-org-3485	125	66	factor	factor	NN
en-wikipedia-org-3485	125	67	–	–	:
en-wikipedia-org-3485	125	68	overexpression	overexpression	NN
en-wikipedia-org-3485	125	69	in	in	IN
en-wikipedia-org-3485	125	70	the	the	DT
en-wikipedia-org-3485	125	71	D1-type	D1-type	NNP
en-wikipedia-org-3485	125	72	medium	medium	JJ
en-wikipedia-org-3485	125	73	spiny	spiny	JJ
en-wikipedia-org-3485	125	74	neurons	neuron	NNS
en-wikipedia-org-3485	125	75	of	of	IN
en-wikipedia-org-3485	125	76	the	the	DT
en-wikipedia-org-3485	125	77	nucleus	nucleus	NN
en-wikipedia-org-3485	125	78	accumbens	accumbens	NNPS
en-wikipedia-org-3485	125	79	is	be	VBZ
en-wikipedia-org-3485	125	80	the	the	DT
en-wikipedia-org-3485	125	81	crucial	crucial	JJ
en-wikipedia-org-3485	125	82	common	common	JJ
en-wikipedia-org-3485	125	83	factor	factor	NN
en-wikipedia-org-3485	125	84	among	among	IN
en-wikipedia-org-3485	125	85	virtually	virtually	RB
en-wikipedia-org-3485	125	86	all	all	DT
en-wikipedia-org-3485	125	87	forms	form	NNS
en-wikipedia-org-3485	125	88	of	of	IN
en-wikipedia-org-3485	125	89	addiction	addiction	NN
en-wikipedia-org-3485	125	90	(	(	-LRB-
en-wikipedia-org-3485	125	91	i.e.	i.e.	FW
en-wikipedia-org-3485	125	92	,	,	,
en-wikipedia-org-3485	125	93	behavioral	behavioral	JJ
en-wikipedia-org-3485	125	94	addictions	addiction	NNS
en-wikipedia-org-3485	125	95	and	and	CC
en-wikipedia-org-3485	125	96	drug	drug	NN
en-wikipedia-org-3485	125	97	addictions	addiction	NNS
en-wikipedia-org-3485	125	98	)	)	-RRB-
en-wikipedia-org-3485	125	99	that	that	WDT
en-wikipedia-org-3485	125	100	induces	induce	VBZ
en-wikipedia-org-3485	125	101	addiction	addiction	NN
en-wikipedia-org-3485	125	102	-	-	HYPH
en-wikipedia-org-3485	125	103	related	relate	VBN
en-wikipedia-org-3485	125	104	behavior	behavior	NN
en-wikipedia-org-3485	125	105	and	and	CC
en-wikipedia-org-3485	125	106	neural	neural	JJ
en-wikipedia-org-3485	125	107	plasticity	plasticity	NN
en-wikipedia-org-3485	125	108	.	.	.
en-wikipedia-org-3485	126	1	[	[	-LRB-
en-wikipedia-org-3485	126	2	5][63][64][65	5][63][64][65	CD
en-wikipedia-org-3485	126	3	]	]	-RRB-
en-wikipedia-org-3485	126	4	In	in	IN
en-wikipedia-org-3485	126	5	particular	particular	JJ
en-wikipedia-org-3485	126	6	,	,	,
en-wikipedia-org-3485	126	7	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	126	8	promotes	promote	VBZ
en-wikipedia-org-3485	126	9	self	self	NN
en-wikipedia-org-3485	126	10	-	-	HYPH
en-wikipedia-org-3485	126	11	administration	administration	NN
en-wikipedia-org-3485	126	12	,	,	,
en-wikipedia-org-3485	126	13	reward	reward	VB
en-wikipedia-org-3485	126	14	sensitization	sensitization	NN
en-wikipedia-org-3485	126	15	,	,	,
en-wikipedia-org-3485	126	16	and	and	CC
en-wikipedia-org-3485	126	17	reward	reward	VB
en-wikipedia-org-3485	126	18	cross	cross	JJ
en-wikipedia-org-3485	126	19	-	-	JJ
en-wikipedia-org-3485	126	20	sensitization	sensitization	JJ
en-wikipedia-org-3485	126	21	effects	effect	NNS
en-wikipedia-org-3485	126	22	among	among	IN
en-wikipedia-org-3485	126	23	specific	specific	JJ
en-wikipedia-org-3485	126	24	addictive	addictive	JJ
en-wikipedia-org-3485	126	25	drugs	drug	NNS
en-wikipedia-org-3485	126	26	and	and	CC
en-wikipedia-org-3485	126	27	behaviors	behavior	NNS
en-wikipedia-org-3485	126	28	.	.	.
en-wikipedia-org-3485	127	1	[	[	-LRB-
en-wikipedia-org-3485	127	2	5][63][64][66][67	5][63][64][66][67	LS
en-wikipedia-org-3485	127	3	]	]	-RRB-
en-wikipedia-org-3485	127	4	Certain	certain	JJ
en-wikipedia-org-3485	127	5	epigenetic	epigenetic	JJ
en-wikipedia-org-3485	127	6	modifications	modification	NNS
en-wikipedia-org-3485	127	7	of	of	IN
en-wikipedia-org-3485	127	8	histone	histone	JJ
en-wikipedia-org-3485	127	9	protein	protein	NN
en-wikipedia-org-3485	127	10	tails	tail	NNS
en-wikipedia-org-3485	127	11	(	(	-LRB-
en-wikipedia-org-3485	127	12	i.e.	i.e.	FW
en-wikipedia-org-3485	127	13	,	,	,
en-wikipedia-org-3485	127	14	histone	histone	NN
en-wikipedia-org-3485	127	15	modifications	modification	NNS
en-wikipedia-org-3485	127	16	)	)	-RRB-
en-wikipedia-org-3485	127	17	in	in	IN
en-wikipedia-org-3485	127	18	specific	specific	JJ
en-wikipedia-org-3485	127	19	regions	region	NNS
en-wikipedia-org-3485	127	20	of	of	IN
en-wikipedia-org-3485	127	21	the	the	DT
en-wikipedia-org-3485	127	22	brain	brain	NN
en-wikipedia-org-3485	127	23	are	be	VBP
en-wikipedia-org-3485	127	24	also	also	RB
en-wikipedia-org-3485	127	25	known	know	VBN
en-wikipedia-org-3485	127	26	to	to	TO
en-wikipedia-org-3485	127	27	play	play	VB
en-wikipedia-org-3485	127	28	a	a	DT
en-wikipedia-org-3485	127	29	crucial	crucial	JJ
en-wikipedia-org-3485	127	30	role	role	NN
en-wikipedia-org-3485	127	31	in	in	IN
en-wikipedia-org-3485	127	32	the	the	DT
en-wikipedia-org-3485	127	33	molecular	molecular	JJ
en-wikipedia-org-3485	127	34	basis	basis	NN
en-wikipedia-org-3485	127	35	of	of	IN
en-wikipedia-org-3485	127	36	addictions	addiction	NNS
en-wikipedia-org-3485	127	37	.	.	.
en-wikipedia-org-3485	128	1	[	[	-LRB-
en-wikipedia-org-3485	128	2	65][68][69][70	65][68][69][70	LS
en-wikipedia-org-3485	128	3	]	]	-RRB-
en-wikipedia-org-3485	128	4	Addictive	addictive	JJ
en-wikipedia-org-3485	128	5	drugs	drug	NNS
en-wikipedia-org-3485	128	6	and	and	CC
en-wikipedia-org-3485	128	7	behaviors	behavior	NNS
en-wikipedia-org-3485	128	8	are	be	VBP
en-wikipedia-org-3485	128	9	rewarding	reward	VBG
en-wikipedia-org-3485	128	10	and	and	CC
en-wikipedia-org-3485	128	11	reinforcing	reinforce	VBG
en-wikipedia-org-3485	128	12	(	(	-LRB-
en-wikipedia-org-3485	128	13	i.e.	i.e.	FW
en-wikipedia-org-3485	128	14	,	,	,
en-wikipedia-org-3485	128	15	are	be	VBP
en-wikipedia-org-3485	128	16	addictive	addictive	JJ
en-wikipedia-org-3485	128	17	)	)	-RRB-
en-wikipedia-org-3485	128	18	due	due	IN
en-wikipedia-org-3485	128	19	to	to	IN
en-wikipedia-org-3485	128	20	their	-PRON-	PRP$
en-wikipedia-org-3485	128	21	effects	effect	NNS
en-wikipedia-org-3485	128	22	on	on	IN
en-wikipedia-org-3485	128	23	the	the	DT
en-wikipedia-org-3485	128	24	dopamine	dopamine	NN
en-wikipedia-org-3485	128	25	reward	reward	NN
en-wikipedia-org-3485	128	26	pathway	pathway	NNP
en-wikipedia-org-3485	128	27	.	.	.
en-wikipedia-org-3485	129	1	[	[	-LRB-
en-wikipedia-org-3485	129	2	16][71	16][71	LS
en-wikipedia-org-3485	129	3	]	]	-RRB-
en-wikipedia-org-3485	129	4	The	the	DT
en-wikipedia-org-3485	129	5	lateral	lateral	JJ
en-wikipedia-org-3485	129	6	hypothalamus	hypothalamus	NN
en-wikipedia-org-3485	129	7	and	and	CC
en-wikipedia-org-3485	129	8	medial	medial	NNP
en-wikipedia-org-3485	129	9	forebrain	forebrain	NNP
en-wikipedia-org-3485	129	10	bundle	bundle	NN
en-wikipedia-org-3485	129	11	has	have	VBZ
en-wikipedia-org-3485	129	12	been	be	VBN
en-wikipedia-org-3485	129	13	the	the	DT
en-wikipedia-org-3485	129	14	most	most	RBS
en-wikipedia-org-3485	129	15	-	-	HYPH
en-wikipedia-org-3485	129	16	frequently	frequently	RB
en-wikipedia-org-3485	129	17	-	-	HYPH
en-wikipedia-org-3485	129	18	studied	study	VBN
en-wikipedia-org-3485	129	19	brain	brain	NN
en-wikipedia-org-3485	129	20	-	-	HYPH
en-wikipedia-org-3485	129	21	stimulation	stimulation	NN
en-wikipedia-org-3485	129	22	reward	reward	NN
en-wikipedia-org-3485	129	23	site	site	NN
en-wikipedia-org-3485	129	24	,	,	,
en-wikipedia-org-3485	129	25	particularly	particularly	RB
en-wikipedia-org-3485	129	26	in	in	IN
en-wikipedia-org-3485	129	27	studies	study	NNS
en-wikipedia-org-3485	129	28	of	of	IN
en-wikipedia-org-3485	129	29	the	the	DT
en-wikipedia-org-3485	129	30	effects	effect	NNS
en-wikipedia-org-3485	129	31	of	of	IN
en-wikipedia-org-3485	129	32	drugs	drug	NNS
en-wikipedia-org-3485	129	33	on	on	IN
en-wikipedia-org-3485	129	34	brain	brain	NN
en-wikipedia-org-3485	129	35	stimulation	stimulation	NN
en-wikipedia-org-3485	129	36	reward	reward	NN
en-wikipedia-org-3485	129	37	.	.	.
en-wikipedia-org-3485	130	1	[	[	-LRB-
en-wikipedia-org-3485	130	2	72	72	CD
en-wikipedia-org-3485	130	3	]	]	-RRB-
en-wikipedia-org-3485	130	4	The	the	DT
en-wikipedia-org-3485	130	5	neurotransmitter	neurotransmitter	NN
en-wikipedia-org-3485	130	6	system	system	NN
en-wikipedia-org-3485	130	7	that	that	WDT
en-wikipedia-org-3485	130	8	has	have	VBZ
en-wikipedia-org-3485	130	9	been	be	VBN
en-wikipedia-org-3485	130	10	most	most	RBS
en-wikipedia-org-3485	130	11	-	-	:
en-wikipedia-org-3485	130	12	clearly	clearly	RB
en-wikipedia-org-3485	130	13	identified	identify	VBN
en-wikipedia-org-3485	130	14	with	with	IN
en-wikipedia-org-3485	130	15	the	the	DT
en-wikipedia-org-3485	130	16	habit	habit	NN
en-wikipedia-org-3485	130	17	-	-	HYPH
en-wikipedia-org-3485	130	18	forming	form	VBG
en-wikipedia-org-3485	130	19	actions	action	NNS
en-wikipedia-org-3485	130	20	of	of	IN
en-wikipedia-org-3485	130	21	drugs	drug	NNS
en-wikipedia-org-3485	130	22	-	-	HYPH
en-wikipedia-org-3485	130	23	of	of	IN
en-wikipedia-org-3485	130	24	-	-	HYPH
en-wikipedia-org-3485	130	25	abuse	abuse	NN
en-wikipedia-org-3485	130	26	is	be	VBZ
en-wikipedia-org-3485	130	27	the	the	DT
en-wikipedia-org-3485	130	28	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	130	29	dopamine	dopamine	NN
en-wikipedia-org-3485	130	30	system	system	NN
en-wikipedia-org-3485	130	31	,	,	,
en-wikipedia-org-3485	130	32	with	with	IN
en-wikipedia-org-3485	130	33	its	-PRON-	PRP$
en-wikipedia-org-3485	130	34	efferent	efferent	NN
en-wikipedia-org-3485	130	35	targets	target	NNS
en-wikipedia-org-3485	130	36	in	in	IN
en-wikipedia-org-3485	130	37	the	the	DT
en-wikipedia-org-3485	130	38	nucleus	nucleus	NN
en-wikipedia-org-3485	130	39	accumbens	accumbens	NNPS
en-wikipedia-org-3485	130	40	and	and	CC
en-wikipedia-org-3485	130	41	its	-PRON-	PRP$
en-wikipedia-org-3485	130	42	local	local	JJ
en-wikipedia-org-3485	130	43	GABAergic	gabaergic	JJ
en-wikipedia-org-3485	130	44	afferents	afferent	NNS
en-wikipedia-org-3485	130	45	.	.	.
en-wikipedia-org-3485	131	1	The	the	DT
en-wikipedia-org-3485	131	2	reward	reward	NN
en-wikipedia-org-3485	131	3	-	-	HYPH
en-wikipedia-org-3485	131	4	relevant	relevant	JJ
en-wikipedia-org-3485	131	5	actions	action	NNS
en-wikipedia-org-3485	131	6	of	of	IN
en-wikipedia-org-3485	131	7	amphetamine	amphetamine	NN
en-wikipedia-org-3485	131	8	and	and	CC
en-wikipedia-org-3485	131	9	cocaine	cocaine	NN
en-wikipedia-org-3485	131	10	are	be	VBP
en-wikipedia-org-3485	131	11	in	in	IN
en-wikipedia-org-3485	131	12	the	the	DT
en-wikipedia-org-3485	131	13	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	131	14	synapses	synapsis	NNS
en-wikipedia-org-3485	131	15	of	of	IN
en-wikipedia-org-3485	131	16	the	the	DT
en-wikipedia-org-3485	131	17	nucleus	nucleus	NN
en-wikipedia-org-3485	131	18	accumbens	accumben	NNS
en-wikipedia-org-3485	131	19	and	and	CC
en-wikipedia-org-3485	131	20	perhaps	perhaps	RB
en-wikipedia-org-3485	131	21	the	the	DT
en-wikipedia-org-3485	131	22	medial	medial	NNP
en-wikipedia-org-3485	131	23	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	131	24	cortex	cortex	NNP
en-wikipedia-org-3485	131	25	.	.	.
en-wikipedia-org-3485	132	1	Rats	rat	NNS
en-wikipedia-org-3485	132	2	also	also	RB
en-wikipedia-org-3485	132	3	learn	learn	VBP
en-wikipedia-org-3485	132	4	to	to	TO
en-wikipedia-org-3485	132	5	lever	lever	NN
en-wikipedia-org-3485	132	6	-	-	HYPH
en-wikipedia-org-3485	132	7	press	press	NN
en-wikipedia-org-3485	132	8	for	for	IN
en-wikipedia-org-3485	132	9	cocaine	cocaine	NN
en-wikipedia-org-3485	132	10	injections	injection	NNS
en-wikipedia-org-3485	132	11	into	into	IN
en-wikipedia-org-3485	132	12	the	the	DT
en-wikipedia-org-3485	132	13	medial	medial	NNP
en-wikipedia-org-3485	132	14	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	132	15	cortex	cortex	NNP
en-wikipedia-org-3485	132	16	,	,	,
en-wikipedia-org-3485	132	17	which	which	WDT
en-wikipedia-org-3485	132	18	works	work	VBZ
en-wikipedia-org-3485	132	19	by	by	IN
en-wikipedia-org-3485	132	20	increasing	increase	VBG
en-wikipedia-org-3485	132	21	dopamine	dopamine	NN
en-wikipedia-org-3485	132	22	turnover	turnover	NN
en-wikipedia-org-3485	132	23	in	in	IN
en-wikipedia-org-3485	132	24	the	the	DT
en-wikipedia-org-3485	132	25	nucleus	nucleus	NN
en-wikipedia-org-3485	132	26	accumbens	accumben	NNS
en-wikipedia-org-3485	132	27	.	.	.
en-wikipedia-org-3485	133	1	[	[	-LRB-
en-wikipedia-org-3485	133	2	73][74	73][74	CD
en-wikipedia-org-3485	133	3	]	]	-RRB-
en-wikipedia-org-3485	133	4	Nicotine	Nicotine	NNP
en-wikipedia-org-3485	133	5	infused	infuse	VBD
en-wikipedia-org-3485	133	6	directly	directly	RB
en-wikipedia-org-3485	133	7	into	into	IN
en-wikipedia-org-3485	133	8	the	the	DT
en-wikipedia-org-3485	133	9	nucleus	nucleus	NN
en-wikipedia-org-3485	133	10	accumbens	accumben	NNS
en-wikipedia-org-3485	133	11	also	also	RB
en-wikipedia-org-3485	133	12	enhances	enhance	VBZ
en-wikipedia-org-3485	133	13	local	local	JJ
en-wikipedia-org-3485	133	14	dopamine	dopamine	NN
en-wikipedia-org-3485	133	15	release	release	NN
en-wikipedia-org-3485	133	16	,	,	,
en-wikipedia-org-3485	133	17	presumably	presumably	RB
en-wikipedia-org-3485	133	18	by	by	IN
en-wikipedia-org-3485	133	19	a	a	DT
en-wikipedia-org-3485	133	20	presynaptic	presynaptic	JJ
en-wikipedia-org-3485	133	21	action	action	NN
en-wikipedia-org-3485	133	22	on	on	IN
en-wikipedia-org-3485	133	23	the	the	DT
en-wikipedia-org-3485	133	24	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	133	25	terminals	terminal	NNS
en-wikipedia-org-3485	133	26	of	of	IN
en-wikipedia-org-3485	133	27	this	this	DT
en-wikipedia-org-3485	133	28	region	region	NN
en-wikipedia-org-3485	133	29	.	.	.
en-wikipedia-org-3485	134	1	Nicotinic	nicotinic	JJ
en-wikipedia-org-3485	134	2	receptors	receptor	NNS
en-wikipedia-org-3485	134	3	localize	localize	VBP
en-wikipedia-org-3485	134	4	to	to	IN
en-wikipedia-org-3485	134	5	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	134	6	cell	cell	NN
en-wikipedia-org-3485	134	7	bodies	body	NNS
en-wikipedia-org-3485	134	8	and	and	CC
en-wikipedia-org-3485	134	9	local	local	JJ
en-wikipedia-org-3485	134	10	nicotine	nicotine	NN
en-wikipedia-org-3485	134	11	injections	injection	NNS
en-wikipedia-org-3485	134	12	increase	increase	VBP
en-wikipedia-org-3485	134	13	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	134	14	cell	cell	NN
en-wikipedia-org-3485	134	15	firing	firing	NN
en-wikipedia-org-3485	134	16	that	that	WDT
en-wikipedia-org-3485	134	17	is	be	VBZ
en-wikipedia-org-3485	134	18	critical	critical	JJ
en-wikipedia-org-3485	134	19	for	for	IN
en-wikipedia-org-3485	134	20	nicotinic	nicotinic	JJ
en-wikipedia-org-3485	134	21	reward	reward	NN
en-wikipedia-org-3485	134	22	.	.	.
en-wikipedia-org-3485	135	1	[	[	-LRB-
en-wikipedia-org-3485	135	2	75][76	75][76	CD
en-wikipedia-org-3485	135	3	]	]	-RRB-
en-wikipedia-org-3485	135	4	Some	some	DT
en-wikipedia-org-3485	135	5	additional	additional	JJ
en-wikipedia-org-3485	135	6	habit	habit	NN
en-wikipedia-org-3485	135	7	-	-	HYPH
en-wikipedia-org-3485	135	8	forming	form	VBG
en-wikipedia-org-3485	135	9	drugs	drug	NNS
en-wikipedia-org-3485	135	10	are	be	VBP
en-wikipedia-org-3485	135	11	also	also	RB
en-wikipedia-org-3485	135	12	likely	likely	JJ
en-wikipedia-org-3485	135	13	to	to	TO
en-wikipedia-org-3485	135	14	decrease	decrease	VB
en-wikipedia-org-3485	135	15	the	the	DT
en-wikipedia-org-3485	135	16	output	output	NN
en-wikipedia-org-3485	135	17	of	of	IN
en-wikipedia-org-3485	135	18	medium	medium	JJ
en-wikipedia-org-3485	135	19	spiny	spiny	JJ
en-wikipedia-org-3485	135	20	neurons	neuron	NNS
en-wikipedia-org-3485	135	21	as	as	IN
en-wikipedia-org-3485	135	22	a	a	DT
en-wikipedia-org-3485	135	23	consequence	consequence	NN
en-wikipedia-org-3485	135	24	,	,	,
en-wikipedia-org-3485	135	25	despite	despite	IN
en-wikipedia-org-3485	135	26	activating	activate	VBG
en-wikipedia-org-3485	135	27	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	135	28	projections	projection	NNS
en-wikipedia-org-3485	135	29	.	.	.
en-wikipedia-org-3485	136	1	For	for	IN
en-wikipedia-org-3485	136	2	opiates	opiate	NNS
en-wikipedia-org-3485	136	3	,	,	,
en-wikipedia-org-3485	136	4	the	the	DT
en-wikipedia-org-3485	136	5	lowest	lowest	RBS
en-wikipedia-org-3485	136	6	-	-	HYPH
en-wikipedia-org-3485	136	7	threshold	threshold	NN
en-wikipedia-org-3485	136	8	site	site	NN
en-wikipedia-org-3485	136	9	for	for	IN
en-wikipedia-org-3485	136	10	reward	reward	NN
en-wikipedia-org-3485	136	11	effects	effect	NNS
en-wikipedia-org-3485	136	12	involves	involve	VBZ
en-wikipedia-org-3485	136	13	actions	action	NNS
en-wikipedia-org-3485	136	14	on	on	IN
en-wikipedia-org-3485	136	15	GABAergic	GABAergic	NNP
en-wikipedia-org-3485	136	16	neurons	neuron	NNS
en-wikipedia-org-3485	136	17	in	in	IN
en-wikipedia-org-3485	136	18	the	the	DT
en-wikipedia-org-3485	136	19	ventral	ventral	JJ
en-wikipedia-org-3485	136	20	tegmental	tegmental	JJ
en-wikipedia-org-3485	136	21	area	area	NN
en-wikipedia-org-3485	136	22	,	,	,
en-wikipedia-org-3485	136	23	a	a	DT
en-wikipedia-org-3485	136	24	secondary	secondary	JJ
en-wikipedia-org-3485	136	25	site	site	NN
en-wikipedia-org-3485	136	26	of	of	IN
en-wikipedia-org-3485	136	27	opiate	opiate	RB
en-wikipedia-org-3485	136	28	-	-	HYPH
en-wikipedia-org-3485	136	29	rewarding	rewarding	JJ
en-wikipedia-org-3485	136	30	actions	action	NNS
en-wikipedia-org-3485	136	31	on	on	IN
en-wikipedia-org-3485	136	32	medium	medium	JJ
en-wikipedia-org-3485	136	33	spiny	spiny	JJ
en-wikipedia-org-3485	136	34	output	output	NN
en-wikipedia-org-3485	136	35	neurons	neuron	NNS
en-wikipedia-org-3485	136	36	of	of	IN
en-wikipedia-org-3485	136	37	the	the	DT
en-wikipedia-org-3485	136	38	nucleus	nucleus	NN
en-wikipedia-org-3485	136	39	accumbens	accumben	NNS
en-wikipedia-org-3485	136	40	.	.	.
en-wikipedia-org-3485	137	1	Thus	thus	RB
en-wikipedia-org-3485	137	2	the	the	DT
en-wikipedia-org-3485	137	3	following	follow	VBG
en-wikipedia-org-3485	137	4	form	form	NN
en-wikipedia-org-3485	137	5	the	the	DT
en-wikipedia-org-3485	137	6	core	core	NN
en-wikipedia-org-3485	137	7	of	of	IN
en-wikipedia-org-3485	137	8	currently	currently	RB
en-wikipedia-org-3485	137	9	characterised	characterise	VBN
en-wikipedia-org-3485	137	10	drug	drug	NN
en-wikipedia-org-3485	137	11	-	-	HYPH
en-wikipedia-org-3485	137	12	reward	reward	NN
en-wikipedia-org-3485	137	13	circuitry	circuitry	NN
en-wikipedia-org-3485	137	14	;	;	:
en-wikipedia-org-3485	137	15	GABAergic	gabaergic	JJ
en-wikipedia-org-3485	137	16	afferents	afferent	NNS
en-wikipedia-org-3485	137	17	to	to	IN
en-wikipedia-org-3485	137	18	the	the	DT
en-wikipedia-org-3485	137	19	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	137	20	dopamine	dopamine	NN
en-wikipedia-org-3485	137	21	neurons	neuron	NNS
en-wikipedia-org-3485	137	22	(	(	-LRB-
en-wikipedia-org-3485	137	23	primary	primary	JJ
en-wikipedia-org-3485	137	24	substrate	substrate	NN
en-wikipedia-org-3485	137	25	of	of	IN
en-wikipedia-org-3485	137	26	opiate	opiate	NNP
en-wikipedia-org-3485	137	27	reward	reward	NNP
en-wikipedia-org-3485	137	28	)	)	-RRB-
en-wikipedia-org-3485	137	29	,	,	,
en-wikipedia-org-3485	137	30	the	the	DT
en-wikipedia-org-3485	137	31	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	137	32	dopamine	dopamine	NN
en-wikipedia-org-3485	137	33	neurons	neuron	NNS
en-wikipedia-org-3485	137	34	themselves	-PRON-	PRP
en-wikipedia-org-3485	137	35	(	(	-LRB-
en-wikipedia-org-3485	137	36	primary	primary	JJ
en-wikipedia-org-3485	137	37	substrate	substrate	NN
en-wikipedia-org-3485	137	38	of	of	IN
en-wikipedia-org-3485	137	39	psychomotor	psychomotor	NN
en-wikipedia-org-3485	137	40	stimulant	stimulant	NN
en-wikipedia-org-3485	137	41	reward	reward	NN
en-wikipedia-org-3485	137	42	)	)	-RRB-
en-wikipedia-org-3485	137	43	,	,	,
en-wikipedia-org-3485	137	44	and	and	CC
en-wikipedia-org-3485	137	45	GABAergic	gabaergic	JJ
en-wikipedia-org-3485	137	46	efferents	efferent	NNS
en-wikipedia-org-3485	137	47	to	to	IN
en-wikipedia-org-3485	137	48	the	the	DT
en-wikipedia-org-3485	137	49	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	137	50	dopamine	dopamine	NN
en-wikipedia-org-3485	137	51	neurons	neuron	NNS
en-wikipedia-org-3485	137	52	(	(	-LRB-
en-wikipedia-org-3485	137	53	a	a	DT
en-wikipedia-org-3485	137	54	secondary	secondary	JJ
en-wikipedia-org-3485	137	55	site	site	NN
en-wikipedia-org-3485	137	56	of	of	IN
en-wikipedia-org-3485	137	57	opiate	opiate	NNP
en-wikipedia-org-3485	137	58	reward	reward	NN
en-wikipedia-org-3485	137	59	)	)	-RRB-
en-wikipedia-org-3485	137	60	.	.	.
en-wikipedia-org-3485	138	1	[	[	-LRB-
en-wikipedia-org-3485	138	2	72	72	CD
en-wikipedia-org-3485	138	3	]	]	-RRB-
en-wikipedia-org-3485	138	4	Motivation[edit	motivation[edit	CD
en-wikipedia-org-3485	138	5	]	]	-RRB-
en-wikipedia-org-3485	138	6	Main	main	JJ
en-wikipedia-org-3485	138	7	article	article	NN
en-wikipedia-org-3485	138	8	:	:	:
en-wikipedia-org-3485	138	9	Motivational	motivational	JJ
en-wikipedia-org-3485	138	10	salience	salience	NN
en-wikipedia-org-3485	138	11	Dysfunctional	dysfunctional	JJ
en-wikipedia-org-3485	138	12	motivational	motivational	JJ
en-wikipedia-org-3485	138	13	salience	salience	NN
en-wikipedia-org-3485	138	14	appears	appear	VBZ
en-wikipedia-org-3485	138	15	in	in	IN
en-wikipedia-org-3485	138	16	a	a	DT
en-wikipedia-org-3485	138	17	number	number	NN
en-wikipedia-org-3485	138	18	of	of	IN
en-wikipedia-org-3485	138	19	psychiatric	psychiatric	JJ
en-wikipedia-org-3485	138	20	symptoms	symptom	NNS
en-wikipedia-org-3485	138	21	and	and	CC
en-wikipedia-org-3485	138	22	disorders	disorder	NNS
en-wikipedia-org-3485	138	23	.	.	.
en-wikipedia-org-3485	139	1	Anhedonia	Anhedonia	NNP
en-wikipedia-org-3485	139	2	,	,	,
en-wikipedia-org-3485	139	3	traditionally	traditionally	RB
en-wikipedia-org-3485	139	4	defined	define	VBN
en-wikipedia-org-3485	139	5	as	as	IN
en-wikipedia-org-3485	139	6	a	a	DT
en-wikipedia-org-3485	139	7	reduced	reduce	VBN
en-wikipedia-org-3485	139	8	capacity	capacity	NN
en-wikipedia-org-3485	139	9	to	to	TO
en-wikipedia-org-3485	139	10	feel	feel	VB
en-wikipedia-org-3485	139	11	pleasure	pleasure	NN
en-wikipedia-org-3485	139	12	,	,	,
en-wikipedia-org-3485	139	13	has	have	VBZ
en-wikipedia-org-3485	139	14	been	be	VBN
en-wikipedia-org-3485	139	15	reexamined	reexamine	VBN
en-wikipedia-org-3485	139	16	as	as	IN
en-wikipedia-org-3485	139	17	reflecting	reflect	VBG
en-wikipedia-org-3485	139	18	blunted	blunt	VBN
en-wikipedia-org-3485	139	19	incentive	incentive	NN
en-wikipedia-org-3485	139	20	salience	salience	NN
en-wikipedia-org-3485	139	21	,	,	,
en-wikipedia-org-3485	139	22	as	as	IN
en-wikipedia-org-3485	139	23	most	most	RBS
en-wikipedia-org-3485	139	24	anhedonic	anhedonic	JJ
en-wikipedia-org-3485	139	25	populations	population	NNS
en-wikipedia-org-3485	139	26	exhibit	exhibit	VBP
en-wikipedia-org-3485	139	27	intact	intact	JJ
en-wikipedia-org-3485	139	28	“	"	``
en-wikipedia-org-3485	139	29	liking	liking	NN
en-wikipedia-org-3485	139	30	”	"	''
en-wikipedia-org-3485	139	31	.	.	.
en-wikipedia-org-3485	140	1	[	[	-LRB-
en-wikipedia-org-3485	140	2	77][78	77][78	CD
en-wikipedia-org-3485	140	3	]	]	-RRB-
en-wikipedia-org-3485	140	4	On	on	IN
en-wikipedia-org-3485	140	5	the	the	DT
en-wikipedia-org-3485	140	6	other	other	JJ
en-wikipedia-org-3485	140	7	end	end	NN
en-wikipedia-org-3485	140	8	of	of	IN
en-wikipedia-org-3485	140	9	the	the	DT
en-wikipedia-org-3485	140	10	spectrum	spectrum	NN
en-wikipedia-org-3485	140	11	,	,	,
en-wikipedia-org-3485	140	12	heightened	heighten	VBD
en-wikipedia-org-3485	140	13	incentive	incentive	NN
en-wikipedia-org-3485	140	14	salience	salience	NN
en-wikipedia-org-3485	140	15	that	that	WDT
en-wikipedia-org-3485	140	16	is	be	VBZ
en-wikipedia-org-3485	140	17	narrowed	narrow	VBN
en-wikipedia-org-3485	140	18	for	for	IN
en-wikipedia-org-3485	140	19	specific	specific	JJ
en-wikipedia-org-3485	140	20	stimuli	stimulus	NNS
en-wikipedia-org-3485	140	21	is	be	VBZ
en-wikipedia-org-3485	140	22	characteristic	characteristic	JJ
en-wikipedia-org-3485	140	23	of	of	IN
en-wikipedia-org-3485	140	24	behavioral	behavioral	JJ
en-wikipedia-org-3485	140	25	and	and	CC
en-wikipedia-org-3485	140	26	drug	drug	NN
en-wikipedia-org-3485	140	27	addictions	addiction	NNS
en-wikipedia-org-3485	140	28	.	.	.
en-wikipedia-org-3485	141	1	In	in	IN
en-wikipedia-org-3485	141	2	the	the	DT
en-wikipedia-org-3485	141	3	case	case	NN
en-wikipedia-org-3485	141	4	of	of	IN
en-wikipedia-org-3485	141	5	fear	fear	NN
en-wikipedia-org-3485	141	6	or	or	CC
en-wikipedia-org-3485	141	7	paranoia	paranoia	NN
en-wikipedia-org-3485	141	8	,	,	,
en-wikipedia-org-3485	141	9	dysfunction	dysfunction	NN
en-wikipedia-org-3485	141	10	may	may	MD
en-wikipedia-org-3485	141	11	lie	lie	VB
en-wikipedia-org-3485	141	12	in	in	IN
en-wikipedia-org-3485	141	13	elevated	elevated	JJ
en-wikipedia-org-3485	141	14	aversive	aversive	JJ
en-wikipedia-org-3485	141	15	salience	salience	NN
en-wikipedia-org-3485	141	16	.	.	.
en-wikipedia-org-3485	142	1	[	[	-LRB-
en-wikipedia-org-3485	142	2	79	79	CD
en-wikipedia-org-3485	142	3	]	]	-RRB-
en-wikipedia-org-3485	142	4	Neuroimaging	Neuroimaging	NNP
en-wikipedia-org-3485	142	5	studies	study	NNS
en-wikipedia-org-3485	142	6	across	across	IN
en-wikipedia-org-3485	142	7	diagnoses	diagnosis	NNS
en-wikipedia-org-3485	142	8	associated	associate	VBN
en-wikipedia-org-3485	142	9	with	with	IN
en-wikipedia-org-3485	142	10	anhedonia	anhedonia	NNP
en-wikipedia-org-3485	142	11	have	have	VBP
en-wikipedia-org-3485	142	12	reported	report	VBN
en-wikipedia-org-3485	142	13	reduced	reduced	JJ
en-wikipedia-org-3485	142	14	activity	activity	NN
en-wikipedia-org-3485	142	15	in	in	IN
en-wikipedia-org-3485	142	16	the	the	DT
en-wikipedia-org-3485	142	17	OFC	OFC	NNP
en-wikipedia-org-3485	142	18	and	and	CC
en-wikipedia-org-3485	142	19	ventral	ventral	JJ
en-wikipedia-org-3485	142	20	striatum	striatum	NN
en-wikipedia-org-3485	142	21	.	.	.
en-wikipedia-org-3485	143	1	[	[	-LRB-
en-wikipedia-org-3485	143	2	80	80	CD
en-wikipedia-org-3485	143	3	]	]	-RRB-
en-wikipedia-org-3485	143	4	One	one	CD
en-wikipedia-org-3485	143	5	meta	meta	JJ
en-wikipedia-org-3485	143	6	analysis	analysis	NN
en-wikipedia-org-3485	143	7	reported	report	VBD
en-wikipedia-org-3485	143	8	anhedonia	anhedonia	NNP
en-wikipedia-org-3485	143	9	was	be	VBD
en-wikipedia-org-3485	143	10	associated	associate	VBN
en-wikipedia-org-3485	143	11	with	with	IN
en-wikipedia-org-3485	143	12	reduced	reduce	VBN
en-wikipedia-org-3485	143	13	neural	neural	JJ
en-wikipedia-org-3485	143	14	response	response	NN
en-wikipedia-org-3485	143	15	to	to	TO
en-wikipedia-org-3485	143	16	reward	reward	VB
en-wikipedia-org-3485	143	17	anticipation	anticipation	NN
en-wikipedia-org-3485	143	18	in	in	IN
en-wikipedia-org-3485	143	19	the	the	DT
en-wikipedia-org-3485	143	20	caudate	caudate	JJ
en-wikipedia-org-3485	143	21	nucleus	nucleus	NN
en-wikipedia-org-3485	143	22	,	,	,
en-wikipedia-org-3485	143	23	putamen	putaman	NNS
en-wikipedia-org-3485	143	24	,	,	,
en-wikipedia-org-3485	143	25	nucleus	nucleus	NNP
en-wikipedia-org-3485	143	26	accumbens	accumben	NNS
en-wikipedia-org-3485	143	27	and	and	CC
en-wikipedia-org-3485	143	28	medial	medial	JJ
en-wikipedia-org-3485	143	29	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	143	30	cortex	cortex	NNP
en-wikipedia-org-3485	143	31	(	(	-LRB-
en-wikipedia-org-3485	143	32	mPFC	mPFC	NNP
en-wikipedia-org-3485	143	33	)	)	-RRB-
en-wikipedia-org-3485	143	34	.	.	.
en-wikipedia-org-3485	144	1	[	[	-LRB-
en-wikipedia-org-3485	144	2	81	81	CD
en-wikipedia-org-3485	144	3	]	]	-RRB-
en-wikipedia-org-3485	144	4	Mood	Mood	NNP
en-wikipedia-org-3485	144	5	disorders[edit	disorders[edit	,
en-wikipedia-org-3485	144	6	]	]	-RRB-
en-wikipedia-org-3485	144	7	Certain	certain	JJ
en-wikipedia-org-3485	144	8	types	type	NNS
en-wikipedia-org-3485	144	9	of	of	IN
en-wikipedia-org-3485	144	10	depression	depression	NN
en-wikipedia-org-3485	144	11	are	be	VBP
en-wikipedia-org-3485	144	12	associated	associate	VBN
en-wikipedia-org-3485	144	13	with	with	IN
en-wikipedia-org-3485	144	14	reduced	reduce	VBN
en-wikipedia-org-3485	144	15	motivation	motivation	NN
en-wikipedia-org-3485	144	16	,	,	,
en-wikipedia-org-3485	144	17	as	as	IN
en-wikipedia-org-3485	144	18	assessed	assess	VBN
en-wikipedia-org-3485	144	19	by	by	IN
en-wikipedia-org-3485	144	20	willingness	willingness	NN
en-wikipedia-org-3485	144	21	to	to	TO
en-wikipedia-org-3485	144	22	expend	expend	VB
en-wikipedia-org-3485	144	23	effort	effort	NN
en-wikipedia-org-3485	144	24	for	for	IN
en-wikipedia-org-3485	144	25	reward	reward	NN
en-wikipedia-org-3485	144	26	.	.	.
en-wikipedia-org-3485	145	1	These	these	DT
en-wikipedia-org-3485	145	2	abnormalities	abnormality	NNS
en-wikipedia-org-3485	145	3	have	have	VBP
en-wikipedia-org-3485	145	4	been	be	VBN
en-wikipedia-org-3485	145	5	tentatively	tentatively	RB
en-wikipedia-org-3485	145	6	linked	link	VBN
en-wikipedia-org-3485	145	7	to	to	IN
en-wikipedia-org-3485	145	8	reduced	reduced	JJ
en-wikipedia-org-3485	145	9	activity	activity	NN
en-wikipedia-org-3485	145	10	in	in	IN
en-wikipedia-org-3485	145	11	areas	area	NNS
en-wikipedia-org-3485	145	12	of	of	IN
en-wikipedia-org-3485	145	13	the	the	DT
en-wikipedia-org-3485	145	14	striatum	striatum	NN
en-wikipedia-org-3485	145	15	,	,	,
en-wikipedia-org-3485	145	16	and	and	CC
en-wikipedia-org-3485	145	17	while	while	IN
en-wikipedia-org-3485	145	18	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	145	19	abnormalities	abnormality	NNS
en-wikipedia-org-3485	145	20	are	be	VBP
en-wikipedia-org-3485	145	21	hypothesized	hypothesize	VBN
en-wikipedia-org-3485	145	22	to	to	TO
en-wikipedia-org-3485	145	23	play	play	VB
en-wikipedia-org-3485	145	24	a	a	DT
en-wikipedia-org-3485	145	25	role	role	NN
en-wikipedia-org-3485	145	26	,	,	,
en-wikipedia-org-3485	145	27	most	most	JJS
en-wikipedia-org-3485	145	28	studies	study	NNS
en-wikipedia-org-3485	145	29	probing	probe	VBG
en-wikipedia-org-3485	145	30	dopamine	dopamine	NN
en-wikipedia-org-3485	145	31	function	function	NN
en-wikipedia-org-3485	145	32	in	in	IN
en-wikipedia-org-3485	145	33	depression	depression	NN
en-wikipedia-org-3485	145	34	have	have	VBP
en-wikipedia-org-3485	145	35	reported	report	VBN
en-wikipedia-org-3485	145	36	inconsistent	inconsistent	JJ
en-wikipedia-org-3485	145	37	results	result	NNS
en-wikipedia-org-3485	145	38	.	.	.
en-wikipedia-org-3485	146	1	[	[	-LRB-
en-wikipedia-org-3485	146	2	82][83	82][83	CD
en-wikipedia-org-3485	146	3	]	]	-RRB-
en-wikipedia-org-3485	146	4	Although	although	IN
en-wikipedia-org-3485	146	5	postmortem	postmortem	NN
en-wikipedia-org-3485	146	6	and	and	CC
en-wikipedia-org-3485	146	7	neuroimaging	neuroimage	VBG
en-wikipedia-org-3485	146	8	studies	study	NNS
en-wikipedia-org-3485	146	9	have	have	VBP
en-wikipedia-org-3485	146	10	found	find	VBN
en-wikipedia-org-3485	146	11	abnormalities	abnormality	NNS
en-wikipedia-org-3485	146	12	in	in	IN
en-wikipedia-org-3485	146	13	numerous	numerous	JJ
en-wikipedia-org-3485	146	14	regions	region	NNS
en-wikipedia-org-3485	146	15	of	of	IN
en-wikipedia-org-3485	146	16	the	the	DT
en-wikipedia-org-3485	146	17	reward	reward	NN
en-wikipedia-org-3485	146	18	system	system	NN
en-wikipedia-org-3485	146	19	,	,	,
en-wikipedia-org-3485	146	20	few	few	JJ
en-wikipedia-org-3485	146	21	findings	finding	NNS
en-wikipedia-org-3485	146	22	are	be	VBP
en-wikipedia-org-3485	146	23	consistently	consistently	RB
en-wikipedia-org-3485	146	24	replicated	replicate	VBN
en-wikipedia-org-3485	146	25	.	.	.
en-wikipedia-org-3485	147	1	Some	some	DT
en-wikipedia-org-3485	147	2	studies	study	NNS
en-wikipedia-org-3485	147	3	have	have	VBP
en-wikipedia-org-3485	147	4	reported	report	VBN
en-wikipedia-org-3485	147	5	reduced	reduce	VBN
en-wikipedia-org-3485	147	6	NAcc	NAcc	NNP
en-wikipedia-org-3485	147	7	,	,	,
en-wikipedia-org-3485	147	8	hippocampus	hippocampus	NNP
en-wikipedia-org-3485	147	9	,	,	,
en-wikipedia-org-3485	147	10	medial	medial	NNP
en-wikipedia-org-3485	147	11	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	147	12	cortex	cortex	NNP
en-wikipedia-org-3485	147	13	(	(	-LRB-
en-wikipedia-org-3485	147	14	mPFC	mPFC	NNP
en-wikipedia-org-3485	147	15	)	)	-RRB-
en-wikipedia-org-3485	147	16	,	,	,
en-wikipedia-org-3485	147	17	and	and	CC
en-wikipedia-org-3485	147	18	orbitofrontal	orbitofrontal	JJ
en-wikipedia-org-3485	147	19	cortex	cortex	NN
en-wikipedia-org-3485	147	20	(	(	-LRB-
en-wikipedia-org-3485	147	21	OFC	OFC	NNP
en-wikipedia-org-3485	147	22	)	)	-RRB-
en-wikipedia-org-3485	147	23	activity	activity	NN
en-wikipedia-org-3485	147	24	,	,	,
en-wikipedia-org-3485	147	25	as	as	RB
en-wikipedia-org-3485	147	26	well	well	RB
en-wikipedia-org-3485	147	27	as	as	IN
en-wikipedia-org-3485	147	28	elevated	elevated	JJ
en-wikipedia-org-3485	147	29	basolateral	basolateral	JJ
en-wikipedia-org-3485	147	30	amygdala	amygdala	JJ
en-wikipedia-org-3485	147	31	and	and	CC
en-wikipedia-org-3485	147	32	subgenual	subgenual	JJ
en-wikipedia-org-3485	147	33	cingulate	cingulate	NN
en-wikipedia-org-3485	147	34	cortex	cortex	NN
en-wikipedia-org-3485	147	35	(	(	-LRB-
en-wikipedia-org-3485	147	36	sgACC	sgacc	UH
en-wikipedia-org-3485	147	37	)	)	-RRB-
en-wikipedia-org-3485	147	38	activity	activity	NN
en-wikipedia-org-3485	147	39	during	during	IN
en-wikipedia-org-3485	147	40	tasks	task	NNS
en-wikipedia-org-3485	147	41	related	relate	VBN
en-wikipedia-org-3485	147	42	to	to	TO
en-wikipedia-org-3485	147	43	reward	reward	VB
en-wikipedia-org-3485	147	44	or	or	CC
en-wikipedia-org-3485	147	45	positive	positive	JJ
en-wikipedia-org-3485	147	46	stimuli	stimulus	NNS
en-wikipedia-org-3485	147	47	.	.	.
en-wikipedia-org-3485	148	1	These	these	DT
en-wikipedia-org-3485	148	2	neuroimaging	neuroimaging	JJ
en-wikipedia-org-3485	148	3	abnormalities	abnormality	NNS
en-wikipedia-org-3485	148	4	are	be	VBP
en-wikipedia-org-3485	148	5	complemented	complement	VBN
en-wikipedia-org-3485	148	6	by	by	IN
en-wikipedia-org-3485	148	7	little	little	JJ
en-wikipedia-org-3485	148	8	post	post	FW
en-wikipedia-org-3485	148	9	mortem	mortem	NN
en-wikipedia-org-3485	148	10	research	research	NN
en-wikipedia-org-3485	148	11	,	,	,
en-wikipedia-org-3485	148	12	but	but	CC
en-wikipedia-org-3485	148	13	what	what	WDT
en-wikipedia-org-3485	148	14	little	little	JJ
en-wikipedia-org-3485	148	15	research	research	NN
en-wikipedia-org-3485	148	16	has	have	VBZ
en-wikipedia-org-3485	148	17	been	be	VBN
en-wikipedia-org-3485	148	18	done	do	VBN
en-wikipedia-org-3485	148	19	suggests	suggest	NNS
en-wikipedia-org-3485	148	20	reduced	reduce	VBN
en-wikipedia-org-3485	148	21	excitatory	excitatory	NN
en-wikipedia-org-3485	148	22	synapses	synapsis	NNS
en-wikipedia-org-3485	148	23	in	in	IN
en-wikipedia-org-3485	148	24	the	the	DT
en-wikipedia-org-3485	148	25	mPFC	mpfc	NN
en-wikipedia-org-3485	148	26	.	.	.
en-wikipedia-org-3485	149	1	[	[	-LRB-
en-wikipedia-org-3485	149	2	84	84	CD
en-wikipedia-org-3485	149	3	]	]	-RRB-
en-wikipedia-org-3485	149	4	Reduced	reduce	VBN
en-wikipedia-org-3485	149	5	activity	activity	NN
en-wikipedia-org-3485	149	6	in	in	IN
en-wikipedia-org-3485	149	7	the	the	DT
en-wikipedia-org-3485	149	8	mPFC	mpfc	NN
en-wikipedia-org-3485	149	9	during	during	IN
en-wikipedia-org-3485	149	10	reward	reward	NN
en-wikipedia-org-3485	149	11	related	related	JJ
en-wikipedia-org-3485	149	12	tasks	task	NNS
en-wikipedia-org-3485	149	13	appears	appear	VBZ
en-wikipedia-org-3485	149	14	to	to	TO
en-wikipedia-org-3485	149	15	be	be	VB
en-wikipedia-org-3485	149	16	localized	localize	VBN
en-wikipedia-org-3485	149	17	to	to	IN
en-wikipedia-org-3485	149	18	more	more	JJR
en-wikipedia-org-3485	149	19	dorsal	dorsal	NN
en-wikipedia-org-3485	149	20	regions(i.e	regions(i.e	NNP
en-wikipedia-org-3485	149	21	.	.	.
en-wikipedia-org-3485	150	1	the	the	DT
en-wikipedia-org-3485	150	2	pregenual	pregenual	JJ
en-wikipedia-org-3485	150	3	cingulate	cingulate	NN
en-wikipedia-org-3485	150	4	cortex	cortex	NN
en-wikipedia-org-3485	150	5	)	)	-RRB-
en-wikipedia-org-3485	150	6	,	,	,
en-wikipedia-org-3485	150	7	while	while	IN
en-wikipedia-org-3485	150	8	the	the	DT
en-wikipedia-org-3485	150	9	more	more	RBR
en-wikipedia-org-3485	150	10	ventral	ventral	JJ
en-wikipedia-org-3485	150	11	sgACC	sgACC	NNP
en-wikipedia-org-3485	150	12	is	be	VBZ
en-wikipedia-org-3485	150	13	hyperactive	hyperactive	JJ
en-wikipedia-org-3485	150	14	in	in	IN
en-wikipedia-org-3485	150	15	depression	depression	NN
en-wikipedia-org-3485	150	16	.	.	.
en-wikipedia-org-3485	151	1	[	[	-LRB-
en-wikipedia-org-3485	151	2	85	85	CD
en-wikipedia-org-3485	151	3	]	]	-RRB-
en-wikipedia-org-3485	151	4	Attempts	attempt	NNS
en-wikipedia-org-3485	151	5	to	to	TO
en-wikipedia-org-3485	151	6	investigate	investigate	VB
en-wikipedia-org-3485	151	7	underlying	underlie	VBG
en-wikipedia-org-3485	151	8	neural	neural	JJ
en-wikipedia-org-3485	151	9	circuitry	circuitry	NN
en-wikipedia-org-3485	151	10	in	in	IN
en-wikipedia-org-3485	151	11	animal	animal	NN
en-wikipedia-org-3485	151	12	models	model	NNS
en-wikipedia-org-3485	151	13	has	have	VBZ
en-wikipedia-org-3485	151	14	also	also	RB
en-wikipedia-org-3485	151	15	yielded	yield	VBN
en-wikipedia-org-3485	151	16	conflicting	conflicting	NN
en-wikipedia-org-3485	151	17	results	result	NNS
en-wikipedia-org-3485	151	18	.	.	.
en-wikipedia-org-3485	152	1	Two	two	CD
en-wikipedia-org-3485	152	2	paradigms	paradigm	NNS
en-wikipedia-org-3485	152	3	are	be	VBP
en-wikipedia-org-3485	152	4	commonly	commonly	RB
en-wikipedia-org-3485	152	5	used	use	VBN
en-wikipedia-org-3485	152	6	to	to	TO
en-wikipedia-org-3485	152	7	simulate	simulate	VB
en-wikipedia-org-3485	152	8	depression	depression	NN
en-wikipedia-org-3485	152	9	,	,	,
en-wikipedia-org-3485	152	10	chronic	chronic	JJ
en-wikipedia-org-3485	152	11	social	social	JJ
en-wikipedia-org-3485	152	12	defeat	defeat	NN
en-wikipedia-org-3485	152	13	(	(	-LRB-
en-wikipedia-org-3485	152	14	CSDS	CSDS	NNP
en-wikipedia-org-3485	152	15	)	)	-RRB-
en-wikipedia-org-3485	152	16	,	,	,
en-wikipedia-org-3485	152	17	and	and	CC
en-wikipedia-org-3485	152	18	chronic	chronic	JJ
en-wikipedia-org-3485	152	19	mild	mild	JJ
en-wikipedia-org-3485	152	20	stress	stress	NN
en-wikipedia-org-3485	152	21	(	(	-LRB-
en-wikipedia-org-3485	152	22	CMS	CMS	NNP
en-wikipedia-org-3485	152	23	)	)	-RRB-
en-wikipedia-org-3485	152	24	,	,	,
en-wikipedia-org-3485	152	25	although	although	IN
en-wikipedia-org-3485	152	26	many	many	JJ
en-wikipedia-org-3485	152	27	exist	exist	VBP
en-wikipedia-org-3485	152	28	.	.	.
en-wikipedia-org-3485	153	1	CSDS	CSDS	NNP
en-wikipedia-org-3485	153	2	produces	produce	VBZ
en-wikipedia-org-3485	153	3	reduced	reduced	JJ
en-wikipedia-org-3485	153	4	preference	preference	NN
en-wikipedia-org-3485	153	5	for	for	IN
en-wikipedia-org-3485	153	6	sucrose	sucrose	JJ
en-wikipedia-org-3485	153	7	,	,	,
en-wikipedia-org-3485	153	8	reduced	reduced	JJ
en-wikipedia-org-3485	153	9	social	social	JJ
en-wikipedia-org-3485	153	10	interactions	interaction	NNS
en-wikipedia-org-3485	153	11	,	,	,
en-wikipedia-org-3485	153	12	and	and	CC
en-wikipedia-org-3485	153	13	increased	increase	VBN
en-wikipedia-org-3485	153	14	immobility	immobility	NN
en-wikipedia-org-3485	153	15	in	in	IN
en-wikipedia-org-3485	153	16	the	the	DT
en-wikipedia-org-3485	153	17	forced	force	VBN
en-wikipedia-org-3485	153	18	swim	swim	NN
en-wikipedia-org-3485	153	19	test	test	NN
en-wikipedia-org-3485	153	20	.	.	.
en-wikipedia-org-3485	154	1	CMS	CMS	NNP
en-wikipedia-org-3485	154	2	similarly	similarly	RB
en-wikipedia-org-3485	154	3	reduces	reduce	VBZ
en-wikipedia-org-3485	154	4	sucrose	sucrose	JJ
en-wikipedia-org-3485	154	5	preference	preference	NN
en-wikipedia-org-3485	154	6	,	,	,
en-wikipedia-org-3485	154	7	and	and	CC
en-wikipedia-org-3485	154	8	behavioral	behavioral	JJ
en-wikipedia-org-3485	154	9	despair	despair	NN
en-wikipedia-org-3485	154	10	as	as	IN
en-wikipedia-org-3485	154	11	assessed	assess	VBN
en-wikipedia-org-3485	154	12	by	by	IN
en-wikipedia-org-3485	154	13	tail	tail	NN
en-wikipedia-org-3485	154	14	suspension	suspension	NN
en-wikipedia-org-3485	154	15	and	and	CC
en-wikipedia-org-3485	154	16	forced	force	VBN
en-wikipedia-org-3485	154	17	swim	swim	NN
en-wikipedia-org-3485	154	18	tests	test	NNS
en-wikipedia-org-3485	154	19	.	.	.
en-wikipedia-org-3485	155	1	Animals	animal	NNS
en-wikipedia-org-3485	155	2	susceptible	susceptible	JJ
en-wikipedia-org-3485	155	3	to	to	IN
en-wikipedia-org-3485	155	4	CSDS	csds	NN
en-wikipedia-org-3485	155	5	exhibit	exhibit	NN
en-wikipedia-org-3485	155	6	increased	increase	VBN
en-wikipedia-org-3485	155	7	phasic	phasic	JJ
en-wikipedia-org-3485	155	8	VTA	VTA	NNP
en-wikipedia-org-3485	155	9	firing	firing	NN
en-wikipedia-org-3485	155	10	,	,	,
en-wikipedia-org-3485	155	11	and	and	CC
en-wikipedia-org-3485	155	12	inhibition	inhibition	NN
en-wikipedia-org-3485	155	13	of	of	IN
en-wikipedia-org-3485	155	14	VTA	VTA	NNP
en-wikipedia-org-3485	155	15	-	-	HYPH
en-wikipedia-org-3485	155	16	NAcc	NAcc	NNP
en-wikipedia-org-3485	155	17	projections	projection	NNS
en-wikipedia-org-3485	155	18	attenuates	attenuate	VBZ
en-wikipedia-org-3485	155	19	behavioral	behavioral	JJ
en-wikipedia-org-3485	155	20	deficits	deficit	NNS
en-wikipedia-org-3485	155	21	induced	induce	VBN
en-wikipedia-org-3485	155	22	by	by	IN
en-wikipedia-org-3485	155	23	CSDS	CSDS	NNP
en-wikipedia-org-3485	155	24	.	.	.
en-wikipedia-org-3485	156	1	[	[	-LRB-
en-wikipedia-org-3485	156	2	86	86	CD
en-wikipedia-org-3485	156	3	]	]	-RRB-
en-wikipedia-org-3485	156	4	However	however	RB
en-wikipedia-org-3485	156	5	,	,	,
en-wikipedia-org-3485	156	6	inhibition	inhibition	NN
en-wikipedia-org-3485	156	7	of	of	IN
en-wikipedia-org-3485	156	8	VTA	VTA	NNP
en-wikipedia-org-3485	156	9	-	-	HYPH
en-wikipedia-org-3485	156	10	mPFC	mpfc	JJ
en-wikipedia-org-3485	156	11	projections	projection	NNS
en-wikipedia-org-3485	156	12	exacerbates	exacerbate	VBZ
en-wikipedia-org-3485	156	13	social	social	JJ
en-wikipedia-org-3485	156	14	withdrawal	withdrawal	NN
en-wikipedia-org-3485	156	15	.	.	.
en-wikipedia-org-3485	157	1	On	on	IN
en-wikipedia-org-3485	157	2	the	the	DT
en-wikipedia-org-3485	157	3	other	other	JJ
en-wikipedia-org-3485	157	4	hand	hand	NN
en-wikipedia-org-3485	157	5	,	,	,
en-wikipedia-org-3485	157	6	CMS	CMS	NNP
en-wikipedia-org-3485	157	7	associated	associate	VBD
en-wikipedia-org-3485	157	8	reductions	reduction	NNS
en-wikipedia-org-3485	157	9	in	in	IN
en-wikipedia-org-3485	157	10	sucrose	sucrose	JJ
en-wikipedia-org-3485	157	11	preference	preference	NN
en-wikipedia-org-3485	157	12	and	and	CC
en-wikipedia-org-3485	157	13	immobility	immobility	NN
en-wikipedia-org-3485	157	14	were	be	VBD
en-wikipedia-org-3485	157	15	attenuated	attenuate	VBN
en-wikipedia-org-3485	157	16	and	and	CC
en-wikipedia-org-3485	157	17	exacerbated	exacerbate	VBN
en-wikipedia-org-3485	157	18	by	by	IN
en-wikipedia-org-3485	157	19	VTA	VTA	NNP
en-wikipedia-org-3485	157	20	excitation	excitation	NN
en-wikipedia-org-3485	157	21	and	and	CC
en-wikipedia-org-3485	157	22	inhibition	inhibition	NN
en-wikipedia-org-3485	157	23	,	,	,
en-wikipedia-org-3485	157	24	respectively	respectively	RB
en-wikipedia-org-3485	157	25	.	.	.
en-wikipedia-org-3485	158	1	[	[	-LRB-
en-wikipedia-org-3485	158	2	87][88	87][88	CD
en-wikipedia-org-3485	158	3	]	]	-RRB-
en-wikipedia-org-3485	158	4	Although	although	IN
en-wikipedia-org-3485	158	5	these	these	DT
en-wikipedia-org-3485	158	6	differences	difference	NNS
en-wikipedia-org-3485	158	7	may	may	MD
en-wikipedia-org-3485	158	8	be	be	VB
en-wikipedia-org-3485	158	9	attributable	attributable	JJ
en-wikipedia-org-3485	158	10	to	to	IN
en-wikipedia-org-3485	158	11	different	different	JJ
en-wikipedia-org-3485	158	12	stimulation	stimulation	NN
en-wikipedia-org-3485	158	13	protocols	protocol	NNS
en-wikipedia-org-3485	158	14	or	or	CC
en-wikipedia-org-3485	158	15	poor	poor	JJ
en-wikipedia-org-3485	158	16	translational	translational	JJ
en-wikipedia-org-3485	158	17	paradigms	paradigm	NNS
en-wikipedia-org-3485	158	18	,	,	,
en-wikipedia-org-3485	158	19	variable	variable	JJ
en-wikipedia-org-3485	158	20	results	result	NNS
en-wikipedia-org-3485	158	21	may	may	MD
en-wikipedia-org-3485	158	22	also	also	RB
en-wikipedia-org-3485	158	23	lie	lie	VB
en-wikipedia-org-3485	158	24	in	in	IN
en-wikipedia-org-3485	158	25	the	the	DT
en-wikipedia-org-3485	158	26	heterogenous	heterogenous	JJ
en-wikipedia-org-3485	158	27	functionality	functionality	NN
en-wikipedia-org-3485	158	28	of	of	IN
en-wikipedia-org-3485	158	29	reward	reward	NN
en-wikipedia-org-3485	158	30	related	related	JJ
en-wikipedia-org-3485	158	31	regions	region	NNS
en-wikipedia-org-3485	158	32	.	.	.
en-wikipedia-org-3485	159	1	[	[	-LRB-
en-wikipedia-org-3485	159	2	89	89	CD
en-wikipedia-org-3485	159	3	]	]	-RRB-
en-wikipedia-org-3485	159	4	Optogenetic	optogenetic	JJ
en-wikipedia-org-3485	159	5	stimulation	stimulation	NN
en-wikipedia-org-3485	159	6	of	of	IN
en-wikipedia-org-3485	159	7	the	the	DT
en-wikipedia-org-3485	159	8	mPFC	mpfc	NN
en-wikipedia-org-3485	159	9	as	as	IN
en-wikipedia-org-3485	159	10	a	a	DT
en-wikipedia-org-3485	159	11	whole	whole	NN
en-wikipedia-org-3485	159	12	produces	produce	VBZ
en-wikipedia-org-3485	159	13	antidepressant	antidepressant	JJ
en-wikipedia-org-3485	159	14	effects	effect	NNS
en-wikipedia-org-3485	159	15	.	.	.
en-wikipedia-org-3485	160	1	This	this	DT
en-wikipedia-org-3485	160	2	effect	effect	NN
en-wikipedia-org-3485	160	3	appears	appear	VBZ
en-wikipedia-org-3485	160	4	localized	localize	VBN
en-wikipedia-org-3485	160	5	to	to	IN
en-wikipedia-org-3485	160	6	the	the	DT
en-wikipedia-org-3485	160	7	rodent	rodent	NN
en-wikipedia-org-3485	160	8	homologue	homologue	NN
en-wikipedia-org-3485	160	9	of	of	IN
en-wikipedia-org-3485	160	10	the	the	DT
en-wikipedia-org-3485	160	11	pgACC	pgacc	NN
en-wikipedia-org-3485	160	12	(	(	-LRB-
en-wikipedia-org-3485	160	13	the	the	DT
en-wikipedia-org-3485	160	14	prelimbic	prelimbic	NNP
en-wikipedia-org-3485	160	15	cortex	cortex	NNP
en-wikipedia-org-3485	160	16	)	)	-RRB-
en-wikipedia-org-3485	160	17	,	,	,
en-wikipedia-org-3485	160	18	as	as	IN
en-wikipedia-org-3485	160	19	stimulation	stimulation	NN
en-wikipedia-org-3485	160	20	of	of	IN
en-wikipedia-org-3485	160	21	the	the	DT
en-wikipedia-org-3485	160	22	rodent	rodent	NN
en-wikipedia-org-3485	160	23	homologue	homologue	NN
en-wikipedia-org-3485	160	24	of	of	IN
en-wikipedia-org-3485	160	25	the	the	DT
en-wikipedia-org-3485	160	26	sgACC	sgACC	NNP
en-wikipedia-org-3485	160	27	(	(	-LRB-
en-wikipedia-org-3485	160	28	the	the	DT
en-wikipedia-org-3485	160	29	infralimbic	infralimbic	NNP
en-wikipedia-org-3485	160	30	cortex	cortex	NNP
en-wikipedia-org-3485	160	31	)	)	-RRB-
en-wikipedia-org-3485	160	32	produces	produce	VBZ
en-wikipedia-org-3485	160	33	no	no	DT
en-wikipedia-org-3485	160	34	behavioral	behavioral	JJ
en-wikipedia-org-3485	160	35	effects	effect	NNS
en-wikipedia-org-3485	160	36	.	.	.
en-wikipedia-org-3485	161	1	Furthermore	furthermore	RB
en-wikipedia-org-3485	161	2	,	,	,
en-wikipedia-org-3485	161	3	deep	deep	JJ
en-wikipedia-org-3485	161	4	brain	brain	NN
en-wikipedia-org-3485	161	5	stimulation	stimulation	NN
en-wikipedia-org-3485	161	6	in	in	IN
en-wikipedia-org-3485	161	7	the	the	DT
en-wikipedia-org-3485	161	8	infralimbic	infralimbic	NNP
en-wikipedia-org-3485	161	9	cortex	cortex	NN
en-wikipedia-org-3485	161	10	,	,	,
en-wikipedia-org-3485	161	11	which	which	WDT
en-wikipedia-org-3485	161	12	is	be	VBZ
en-wikipedia-org-3485	161	13	thought	think	VBN
en-wikipedia-org-3485	161	14	to	to	TO
en-wikipedia-org-3485	161	15	have	have	VB
en-wikipedia-org-3485	161	16	an	an	DT
en-wikipedia-org-3485	161	17	inhibitory	inhibitory	JJ
en-wikipedia-org-3485	161	18	effect	effect	NN
en-wikipedia-org-3485	161	19	,	,	,
en-wikipedia-org-3485	161	20	also	also	RB
en-wikipedia-org-3485	161	21	produces	produce	VBZ
en-wikipedia-org-3485	161	22	an	an	DT
en-wikipedia-org-3485	161	23	antidepressant	antidepressant	JJ
en-wikipedia-org-3485	161	24	effect	effect	NN
en-wikipedia-org-3485	161	25	.	.	.
en-wikipedia-org-3485	162	1	This	this	DT
en-wikipedia-org-3485	162	2	finding	finding	NN
en-wikipedia-org-3485	162	3	is	be	VBZ
en-wikipedia-org-3485	162	4	congruent	congruent	JJ
en-wikipedia-org-3485	162	5	with	with	IN
en-wikipedia-org-3485	162	6	the	the	DT
en-wikipedia-org-3485	162	7	observation	observation	NN
en-wikipedia-org-3485	162	8	that	that	IN
en-wikipedia-org-3485	162	9	pharmacological	pharmacological	JJ
en-wikipedia-org-3485	162	10	inhibition	inhibition	NN
en-wikipedia-org-3485	162	11	of	of	IN
en-wikipedia-org-3485	162	12	the	the	DT
en-wikipedia-org-3485	162	13	infralimbic	infralimbic	NNP
en-wikipedia-org-3485	162	14	cortex	cortex	NN
en-wikipedia-org-3485	162	15	attenuates	attenuate	NNS
en-wikipedia-org-3485	162	16	depressive	depressive	JJ
en-wikipedia-org-3485	162	17	behaviors	behavior	NNS
en-wikipedia-org-3485	162	18	.	.	.
en-wikipedia-org-3485	163	1	[	[	-LRB-
en-wikipedia-org-3485	163	2	89	89	CD
en-wikipedia-org-3485	163	3	]	]	-RRB-
en-wikipedia-org-3485	163	4	Schizophrenia[edit	schizophrenia[edit	CD
en-wikipedia-org-3485	163	5	]	]	-RRB-
en-wikipedia-org-3485	163	6	Schizophrenia	Schizophrenia	NNP
en-wikipedia-org-3485	163	7	is	be	VBZ
en-wikipedia-org-3485	163	8	associated	associate	VBN
en-wikipedia-org-3485	163	9	with	with	IN
en-wikipedia-org-3485	163	10	deficits	deficit	NNS
en-wikipedia-org-3485	163	11	in	in	IN
en-wikipedia-org-3485	163	12	motivation	motivation	NN
en-wikipedia-org-3485	163	13	,	,	,
en-wikipedia-org-3485	163	14	commonly	commonly	RB
en-wikipedia-org-3485	163	15	grouped	group	VBN
en-wikipedia-org-3485	163	16	under	under	IN
en-wikipedia-org-3485	163	17	other	other	JJ
en-wikipedia-org-3485	163	18	negative	negative	JJ
en-wikipedia-org-3485	163	19	symptoms	symptom	NNS
en-wikipedia-org-3485	163	20	such	such	JJ
en-wikipedia-org-3485	163	21	as	as	IN
en-wikipedia-org-3485	163	22	reduced	reduced	JJ
en-wikipedia-org-3485	163	23	spontaneous	spontaneous	JJ
en-wikipedia-org-3485	163	24	speech	speech	NN
en-wikipedia-org-3485	163	25	.	.	.
en-wikipedia-org-3485	164	1	The	the	DT
en-wikipedia-org-3485	164	2	experience	experience	NN
en-wikipedia-org-3485	164	3	of	of	IN
en-wikipedia-org-3485	164	4	“	"	``
en-wikipedia-org-3485	164	5	liking	like	VBG
en-wikipedia-org-3485	164	6	”	"	''
en-wikipedia-org-3485	164	7	is	be	VBZ
en-wikipedia-org-3485	164	8	frequently	frequently	RB
en-wikipedia-org-3485	164	9	reported	report	VBN
en-wikipedia-org-3485	164	10	to	to	TO
en-wikipedia-org-3485	164	11	be	be	VB
en-wikipedia-org-3485	164	12	intact,[90	intact,[90	CD
en-wikipedia-org-3485	164	13	]	]	-RRB-
en-wikipedia-org-3485	164	14	both	both	DT
en-wikipedia-org-3485	164	15	behaviorally	behaviorally	RB
en-wikipedia-org-3485	164	16	and	and	CC
en-wikipedia-org-3485	164	17	neurally	neurally	RB
en-wikipedia-org-3485	164	18	,	,	,
en-wikipedia-org-3485	164	19	although	although	IN
en-wikipedia-org-3485	164	20	results	result	NNS
en-wikipedia-org-3485	164	21	may	may	MD
en-wikipedia-org-3485	164	22	be	be	VB
en-wikipedia-org-3485	164	23	specific	specific	JJ
en-wikipedia-org-3485	164	24	to	to	IN
en-wikipedia-org-3485	164	25	certain	certain	JJ
en-wikipedia-org-3485	164	26	stimuli	stimulus	NNS
en-wikipedia-org-3485	164	27	,	,	,
en-wikipedia-org-3485	164	28	such	such	JJ
en-wikipedia-org-3485	164	29	as	as	IN
en-wikipedia-org-3485	164	30	monetary	monetary	JJ
en-wikipedia-org-3485	164	31	rewards	reward	NNS
en-wikipedia-org-3485	164	32	.	.	.
en-wikipedia-org-3485	165	1	[	[	-LRB-
en-wikipedia-org-3485	165	2	91	91	CD
en-wikipedia-org-3485	165	3	]	]	-RRB-
en-wikipedia-org-3485	165	4	Furthermore	furthermore	RB
en-wikipedia-org-3485	165	5	,	,	,
en-wikipedia-org-3485	165	6	implicit	implicit	JJ
en-wikipedia-org-3485	165	7	learning	learning	NN
en-wikipedia-org-3485	165	8	and	and	CC
en-wikipedia-org-3485	165	9	simple	simple	JJ
en-wikipedia-org-3485	165	10	reward	reward	NN
en-wikipedia-org-3485	165	11	-	-	HYPH
en-wikipedia-org-3485	165	12	related	relate	VBN
en-wikipedia-org-3485	165	13	tasks	task	NNS
en-wikipedia-org-3485	165	14	are	be	VBP
en-wikipedia-org-3485	165	15	also	also	RB
en-wikipedia-org-3485	165	16	intact	intact	JJ
en-wikipedia-org-3485	165	17	in	in	IN
en-wikipedia-org-3485	165	18	schizophrenia	schizophrenia	NN
en-wikipedia-org-3485	165	19	.	.	.
en-wikipedia-org-3485	166	1	[	[	-LRB-
en-wikipedia-org-3485	166	2	92	92	CD
en-wikipedia-org-3485	166	3	]	]	-RRB-
en-wikipedia-org-3485	166	4	Rather	rather	RB
en-wikipedia-org-3485	166	5	,	,	,
en-wikipedia-org-3485	166	6	deficits	deficit	NNS
en-wikipedia-org-3485	166	7	in	in	IN
en-wikipedia-org-3485	166	8	the	the	DT
en-wikipedia-org-3485	166	9	reward	reward	NN
en-wikipedia-org-3485	166	10	system	system	NN
en-wikipedia-org-3485	166	11	are	be	VBP
en-wikipedia-org-3485	166	12	apparent	apparent	JJ
en-wikipedia-org-3485	166	13	during	during	IN
en-wikipedia-org-3485	166	14	reward	reward	NN
en-wikipedia-org-3485	166	15	-	-	HYPH
en-wikipedia-org-3485	166	16	related	relate	VBN
en-wikipedia-org-3485	166	17	tasks	task	NNS
en-wikipedia-org-3485	166	18	that	that	WDT
en-wikipedia-org-3485	166	19	are	be	VBP
en-wikipedia-org-3485	166	20	cognitively	cognitively	RB
en-wikipedia-org-3485	166	21	complex	complex	JJ
en-wikipedia-org-3485	166	22	.	.	.
en-wikipedia-org-3485	167	1	These	these	DT
en-wikipedia-org-3485	167	2	deficits	deficit	NNS
en-wikipedia-org-3485	167	3	are	be	VBP
en-wikipedia-org-3485	167	4	associated	associate	VBN
en-wikipedia-org-3485	167	5	with	with	IN
en-wikipedia-org-3485	167	6	both	both	CC
en-wikipedia-org-3485	167	7	abnormal	abnormal	JJ
en-wikipedia-org-3485	167	8	striatal	striatal	JJ
en-wikipedia-org-3485	167	9	and	and	CC
en-wikipedia-org-3485	167	10	OFC	OFC	NNP
en-wikipedia-org-3485	167	11	activity	activity	NN
en-wikipedia-org-3485	167	12	,	,	,
en-wikipedia-org-3485	167	13	as	as	RB
en-wikipedia-org-3485	167	14	well	well	RB
en-wikipedia-org-3485	167	15	as	as	IN
en-wikipedia-org-3485	167	16	abnormalities	abnormality	NNS
en-wikipedia-org-3485	167	17	in	in	IN
en-wikipedia-org-3485	167	18	regions	region	NNS
en-wikipedia-org-3485	167	19	associated	associate	VBN
en-wikipedia-org-3485	167	20	with	with	IN
en-wikipedia-org-3485	167	21	cognitive	cognitive	JJ
en-wikipedia-org-3485	167	22	functions	function	NNS
en-wikipedia-org-3485	167	23	such	such	JJ
en-wikipedia-org-3485	167	24	as	as	IN
en-wikipedia-org-3485	167	25	the	the	DT
en-wikipedia-org-3485	167	26	dorsolateral	dorsolateral	JJ
en-wikipedia-org-3485	167	27	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	167	28	cortex	cortex	NNP
en-wikipedia-org-3485	167	29	(	(	-LRB-
en-wikipedia-org-3485	167	30	DLPFC	DLPFC	NNP
en-wikipedia-org-3485	167	31	)	)	-RRB-
en-wikipedia-org-3485	167	32	.	.	.
en-wikipedia-org-3485	168	1	[	[	-LRB-
en-wikipedia-org-3485	168	2	93	93	CD
en-wikipedia-org-3485	168	3	]	]	-RRB-
en-wikipedia-org-3485	168	4	History[edit	History[edit	VBN
en-wikipedia-org-3485	168	5	]	]	-RRB-
en-wikipedia-org-3485	168	6	Skinner	Skinner	NNP
en-wikipedia-org-3485	168	7	box	box	NN
en-wikipedia-org-3485	168	8	The	the	DT
en-wikipedia-org-3485	168	9	first	first	JJ
en-wikipedia-org-3485	168	10	clue	clue	NN
en-wikipedia-org-3485	168	11	to	to	IN
en-wikipedia-org-3485	168	12	the	the	DT
en-wikipedia-org-3485	168	13	presence	presence	NN
en-wikipedia-org-3485	168	14	of	of	IN
en-wikipedia-org-3485	168	15	a	a	DT
en-wikipedia-org-3485	168	16	reward	reward	NN
en-wikipedia-org-3485	168	17	system	system	NN
en-wikipedia-org-3485	168	18	in	in	IN
en-wikipedia-org-3485	168	19	the	the	DT
en-wikipedia-org-3485	168	20	brain	brain	NN
en-wikipedia-org-3485	168	21	came	come	VBD
en-wikipedia-org-3485	168	22	with	with	IN
en-wikipedia-org-3485	168	23	an	an	DT
en-wikipedia-org-3485	168	24	accident	accident	NN
en-wikipedia-org-3485	168	25	discovery	discovery	NN
en-wikipedia-org-3485	168	26	by	by	IN
en-wikipedia-org-3485	168	27	James	James	NNP
en-wikipedia-org-3485	168	28	Olds	Olds	NNP
en-wikipedia-org-3485	168	29	and	and	CC
en-wikipedia-org-3485	168	30	Peter	Peter	NNP
en-wikipedia-org-3485	168	31	Milner	Milner	NNP
en-wikipedia-org-3485	168	32	in	in	IN
en-wikipedia-org-3485	168	33	1954	1954	CD
en-wikipedia-org-3485	168	34	.	.	.
en-wikipedia-org-3485	169	1	They	-PRON-	PRP
en-wikipedia-org-3485	169	2	discovered	discover	VBD
en-wikipedia-org-3485	169	3	that	that	IN
en-wikipedia-org-3485	169	4	rats	rat	NNS
en-wikipedia-org-3485	169	5	would	would	MD
en-wikipedia-org-3485	169	6	perform	perform	VB
en-wikipedia-org-3485	169	7	behaviors	behavior	NNS
en-wikipedia-org-3485	169	8	such	such	JJ
en-wikipedia-org-3485	169	9	as	as	IN
en-wikipedia-org-3485	169	10	pressing	press	VBG
en-wikipedia-org-3485	169	11	a	a	DT
en-wikipedia-org-3485	169	12	bar	bar	NN
en-wikipedia-org-3485	169	13	,	,	,
en-wikipedia-org-3485	169	14	to	to	TO
en-wikipedia-org-3485	169	15	administer	administer	VB
en-wikipedia-org-3485	169	16	a	a	DT
en-wikipedia-org-3485	169	17	brief	brief	JJ
en-wikipedia-org-3485	169	18	burst	burst	NN
en-wikipedia-org-3485	169	19	of	of	IN
en-wikipedia-org-3485	169	20	electrical	electrical	JJ
en-wikipedia-org-3485	169	21	stimulation	stimulation	NN
en-wikipedia-org-3485	169	22	to	to	IN
en-wikipedia-org-3485	169	23	specific	specific	JJ
en-wikipedia-org-3485	169	24	sites	site	NNS
en-wikipedia-org-3485	169	25	in	in	IN
en-wikipedia-org-3485	169	26	their	-PRON-	PRP$
en-wikipedia-org-3485	169	27	brains	brain	NNS
en-wikipedia-org-3485	169	28	.	.	.
en-wikipedia-org-3485	170	1	This	this	DT
en-wikipedia-org-3485	170	2	phenomenon	phenomenon	NN
en-wikipedia-org-3485	170	3	is	be	VBZ
en-wikipedia-org-3485	170	4	called	call	VBN
en-wikipedia-org-3485	170	5	intracranial	intracranial	JJ
en-wikipedia-org-3485	170	6	self	self	NN
en-wikipedia-org-3485	170	7	-	-	HYPH
en-wikipedia-org-3485	170	8	stimulation	stimulation	NN
en-wikipedia-org-3485	170	9	or	or	CC
en-wikipedia-org-3485	170	10	brain	brain	NN
en-wikipedia-org-3485	170	11	stimulation	stimulation	NN
en-wikipedia-org-3485	170	12	reward	reward	NN
en-wikipedia-org-3485	170	13	.	.	.
en-wikipedia-org-3485	171	1	Typically	typically	RB
en-wikipedia-org-3485	171	2	,	,	,
en-wikipedia-org-3485	171	3	rats	rat	NNS
en-wikipedia-org-3485	171	4	will	will	MD
en-wikipedia-org-3485	171	5	press	press	VB
en-wikipedia-org-3485	171	6	a	a	DT
en-wikipedia-org-3485	171	7	lever	lever	NN
en-wikipedia-org-3485	171	8	hundreds	hundred	NNS
en-wikipedia-org-3485	171	9	or	or	CC
en-wikipedia-org-3485	171	10	thousands	thousand	NNS
en-wikipedia-org-3485	171	11	of	of	IN
en-wikipedia-org-3485	171	12	times	time	NNS
en-wikipedia-org-3485	171	13	per	per	IN
en-wikipedia-org-3485	171	14	hour	hour	NN
en-wikipedia-org-3485	171	15	to	to	TO
en-wikipedia-org-3485	171	16	obtain	obtain	VB
en-wikipedia-org-3485	171	17	this	this	DT
en-wikipedia-org-3485	171	18	brain	brain	NN
en-wikipedia-org-3485	171	19	stimulation	stimulation	NN
en-wikipedia-org-3485	171	20	,	,	,
en-wikipedia-org-3485	171	21	stopping	stop	VBG
en-wikipedia-org-3485	171	22	only	only	RB
en-wikipedia-org-3485	171	23	when	when	WRB
en-wikipedia-org-3485	171	24	they	-PRON-	PRP
en-wikipedia-org-3485	171	25	are	be	VBP
en-wikipedia-org-3485	171	26	exhausted	exhaust	VBN
en-wikipedia-org-3485	171	27	.	.	.
en-wikipedia-org-3485	172	1	While	while	IN
en-wikipedia-org-3485	172	2	trying	try	VBG
en-wikipedia-org-3485	172	3	to	to	TO
en-wikipedia-org-3485	172	4	teach	teach	VB
en-wikipedia-org-3485	172	5	rats	rat	NNS
en-wikipedia-org-3485	172	6	how	how	WRB
en-wikipedia-org-3485	172	7	to	to	TO
en-wikipedia-org-3485	172	8	solve	solve	VB
en-wikipedia-org-3485	172	9	problems	problem	NNS
en-wikipedia-org-3485	172	10	and	and	CC
en-wikipedia-org-3485	172	11	run	run	VB
en-wikipedia-org-3485	172	12	mazes	maze	NNS
en-wikipedia-org-3485	172	13	,	,	,
en-wikipedia-org-3485	172	14	stimulation	stimulation	NN
en-wikipedia-org-3485	172	15	of	of	IN
en-wikipedia-org-3485	172	16	certain	certain	JJ
en-wikipedia-org-3485	172	17	regions	region	NNS
en-wikipedia-org-3485	172	18	of	of	IN
en-wikipedia-org-3485	172	19	the	the	DT
en-wikipedia-org-3485	172	20	brain	brain	NN
en-wikipedia-org-3485	172	21	where	where	WRB
en-wikipedia-org-3485	172	22	the	the	DT
en-wikipedia-org-3485	172	23	stimulation	stimulation	NN
en-wikipedia-org-3485	172	24	was	be	VBD
en-wikipedia-org-3485	172	25	found	find	VBN
en-wikipedia-org-3485	172	26	seemed	seem	VBD
en-wikipedia-org-3485	172	27	to	to	TO
en-wikipedia-org-3485	172	28	give	give	VB
en-wikipedia-org-3485	172	29	pleasure	pleasure	NN
en-wikipedia-org-3485	172	30	to	to	IN
en-wikipedia-org-3485	172	31	the	the	DT
en-wikipedia-org-3485	172	32	animals	animal	NNS
en-wikipedia-org-3485	172	33	.	.	.
en-wikipedia-org-3485	173	1	They	-PRON-	PRP
en-wikipedia-org-3485	173	2	tried	try	VBD
en-wikipedia-org-3485	173	3	the	the	DT
en-wikipedia-org-3485	173	4	same	same	JJ
en-wikipedia-org-3485	173	5	thing	thing	NN
en-wikipedia-org-3485	173	6	with	with	IN
en-wikipedia-org-3485	173	7	humans	human	NNS
en-wikipedia-org-3485	173	8	and	and	CC
en-wikipedia-org-3485	173	9	the	the	DT
en-wikipedia-org-3485	173	10	results	result	NNS
en-wikipedia-org-3485	173	11	were	be	VBD
en-wikipedia-org-3485	173	12	similar	similar	JJ
en-wikipedia-org-3485	173	13	.	.	.
en-wikipedia-org-3485	174	1	The	the	DT
en-wikipedia-org-3485	174	2	explanation	explanation	NN
en-wikipedia-org-3485	174	3	to	to	IN
en-wikipedia-org-3485	174	4	why	why	WRB
en-wikipedia-org-3485	174	5	animals	animal	NNS
en-wikipedia-org-3485	174	6	engage	engage	VBP
en-wikipedia-org-3485	174	7	in	in	IN
en-wikipedia-org-3485	174	8	a	a	DT
en-wikipedia-org-3485	174	9	behavior	behavior	NN
en-wikipedia-org-3485	174	10	that	that	WDT
en-wikipedia-org-3485	174	11	has	have	VBZ
en-wikipedia-org-3485	174	12	no	no	DT
en-wikipedia-org-3485	174	13	value	value	NN
en-wikipedia-org-3485	174	14	to	to	IN
en-wikipedia-org-3485	174	15	the	the	DT
en-wikipedia-org-3485	174	16	survival	survival	NN
en-wikipedia-org-3485	174	17	of	of	IN
en-wikipedia-org-3485	174	18	either	either	CC
en-wikipedia-org-3485	174	19	themselves	-PRON-	PRP
en-wikipedia-org-3485	174	20	or	or	CC
en-wikipedia-org-3485	174	21	their	-PRON-	PRP$
en-wikipedia-org-3485	174	22	species	specie	NNS
en-wikipedia-org-3485	174	23	is	be	VBZ
en-wikipedia-org-3485	174	24	that	that	IN
en-wikipedia-org-3485	174	25	the	the	DT
en-wikipedia-org-3485	174	26	brain	brain	NN
en-wikipedia-org-3485	174	27	stimulation	stimulation	NN
en-wikipedia-org-3485	174	28	is	be	VBZ
en-wikipedia-org-3485	174	29	activating	activate	VBG
en-wikipedia-org-3485	174	30	the	the	DT
en-wikipedia-org-3485	174	31	system	system	NN
en-wikipedia-org-3485	174	32	underlying	underlie	VBG
en-wikipedia-org-3485	174	33	reward	reward	NN
en-wikipedia-org-3485	174	34	.	.	.
en-wikipedia-org-3485	175	1	[	[	-LRB-
en-wikipedia-org-3485	175	2	94	94	CD
en-wikipedia-org-3485	175	3	]	]	-RRB-
en-wikipedia-org-3485	175	4	In	in	IN
en-wikipedia-org-3485	175	5	a	a	DT
en-wikipedia-org-3485	175	6	fundamental	fundamental	JJ
en-wikipedia-org-3485	175	7	discovery	discovery	NN
en-wikipedia-org-3485	175	8	made	make	VBN
en-wikipedia-org-3485	175	9	in	in	IN
en-wikipedia-org-3485	175	10	1954	1954	CD
en-wikipedia-org-3485	175	11	,	,	,
en-wikipedia-org-3485	175	12	researchers	researcher	NNS
en-wikipedia-org-3485	175	13	James	James	NNP
en-wikipedia-org-3485	175	14	Olds	Olds	NNP
en-wikipedia-org-3485	175	15	and	and	CC
en-wikipedia-org-3485	175	16	Peter	Peter	NNP
en-wikipedia-org-3485	175	17	Milner	Milner	NNP
en-wikipedia-org-3485	175	18	found	find	VBD
en-wikipedia-org-3485	175	19	that	that	IN
en-wikipedia-org-3485	175	20	low	low	JJ
en-wikipedia-org-3485	175	21	-	-	HYPH
en-wikipedia-org-3485	175	22	voltage	voltage	NN
en-wikipedia-org-3485	175	23	electrical	electrical	JJ
en-wikipedia-org-3485	175	24	stimulation	stimulation	NN
en-wikipedia-org-3485	175	25	of	of	IN
en-wikipedia-org-3485	175	26	certain	certain	JJ
en-wikipedia-org-3485	175	27	regions	region	NNS
en-wikipedia-org-3485	175	28	of	of	IN
en-wikipedia-org-3485	175	29	the	the	DT
en-wikipedia-org-3485	175	30	brain	brain	NN
en-wikipedia-org-3485	175	31	of	of	IN
en-wikipedia-org-3485	175	32	the	the	DT
en-wikipedia-org-3485	175	33	rat	rat	NN
en-wikipedia-org-3485	175	34	acted	act	VBD
en-wikipedia-org-3485	175	35	as	as	IN
en-wikipedia-org-3485	175	36	a	a	DT
en-wikipedia-org-3485	175	37	reward	reward	NN
en-wikipedia-org-3485	175	38	in	in	IN
en-wikipedia-org-3485	175	39	teaching	teach	VBG
en-wikipedia-org-3485	175	40	the	the	DT
en-wikipedia-org-3485	175	41	animals	animal	NNS
en-wikipedia-org-3485	175	42	to	to	TO
en-wikipedia-org-3485	175	43	run	run	VB
en-wikipedia-org-3485	175	44	mazes	maze	NNS
en-wikipedia-org-3485	175	45	and	and	CC
en-wikipedia-org-3485	175	46	solve	solve	VB
en-wikipedia-org-3485	175	47	problems	problem	NNS
en-wikipedia-org-3485	175	48	.	.	.
en-wikipedia-org-3485	176	1	[	[	-LRB-
en-wikipedia-org-3485	176	2	95][96	95][96	CD
en-wikipedia-org-3485	176	3	]	]	-RRB-
en-wikipedia-org-3485	176	4	It	-PRON-	PRP
en-wikipedia-org-3485	176	5	seemed	seem	VBD
en-wikipedia-org-3485	176	6	that	that	IN
en-wikipedia-org-3485	176	7	stimulation	stimulation	NN
en-wikipedia-org-3485	176	8	of	of	IN
en-wikipedia-org-3485	176	9	those	those	DT
en-wikipedia-org-3485	176	10	parts	part	NNS
en-wikipedia-org-3485	176	11	of	of	IN
en-wikipedia-org-3485	176	12	the	the	DT
en-wikipedia-org-3485	176	13	brain	brain	NN
en-wikipedia-org-3485	176	14	gave	give	VBD
en-wikipedia-org-3485	176	15	the	the	DT
en-wikipedia-org-3485	176	16	animals	animal	NNS
en-wikipedia-org-3485	176	17	pleasure,[95	pleasure,[95	CD
en-wikipedia-org-3485	176	18	]	]	-RRB-
en-wikipedia-org-3485	176	19	and	and	CC
en-wikipedia-org-3485	176	20	in	in	IN
en-wikipedia-org-3485	176	21	later	later	JJ
en-wikipedia-org-3485	176	22	work	work	NN
en-wikipedia-org-3485	176	23	humans	human	NNS
en-wikipedia-org-3485	176	24	reported	report	VBD
en-wikipedia-org-3485	176	25	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	176	26	sensations	sensation	NNS
en-wikipedia-org-3485	176	27	from	from	IN
en-wikipedia-org-3485	176	28	such	such	JJ
en-wikipedia-org-3485	176	29	stimulation	stimulation	NN
en-wikipedia-org-3485	176	30	.	.	.
en-wikipedia-org-3485	177	1	When	when	WRB
en-wikipedia-org-3485	177	2	rats	rat	NNS
en-wikipedia-org-3485	177	3	were	be	VBD
en-wikipedia-org-3485	177	4	tested	test	VBN
en-wikipedia-org-3485	177	5	in	in	IN
en-wikipedia-org-3485	177	6	Skinner	Skinner	NNP
en-wikipedia-org-3485	177	7	boxes	box	NNS
en-wikipedia-org-3485	177	8	where	where	WRB
en-wikipedia-org-3485	177	9	they	-PRON-	PRP
en-wikipedia-org-3485	177	10	could	could	MD
en-wikipedia-org-3485	177	11	stimulate	stimulate	VB
en-wikipedia-org-3485	177	12	the	the	DT
en-wikipedia-org-3485	177	13	reward	reward	NN
en-wikipedia-org-3485	177	14	system	system	NN
en-wikipedia-org-3485	177	15	by	by	IN
en-wikipedia-org-3485	177	16	pressing	press	VBG
en-wikipedia-org-3485	177	17	a	a	DT
en-wikipedia-org-3485	177	18	lever	lever	NN
en-wikipedia-org-3485	177	19	,	,	,
en-wikipedia-org-3485	177	20	the	the	DT
en-wikipedia-org-3485	177	21	rats	rat	NNS
en-wikipedia-org-3485	177	22	pressed	press	VBN
en-wikipedia-org-3485	177	23	for	for	IN
en-wikipedia-org-3485	177	24	hours	hour	NNS
en-wikipedia-org-3485	177	25	.	.	.
en-wikipedia-org-3485	178	1	[	[	-LRB-
en-wikipedia-org-3485	178	2	96	96	CD
en-wikipedia-org-3485	178	3	]	]	-RRB-
en-wikipedia-org-3485	178	4	Research	research	NN
en-wikipedia-org-3485	178	5	in	in	IN
en-wikipedia-org-3485	178	6	the	the	DT
en-wikipedia-org-3485	178	7	next	next	JJ
en-wikipedia-org-3485	178	8	two	two	CD
en-wikipedia-org-3485	178	9	decades	decade	NNS
en-wikipedia-org-3485	178	10	established	establish	VBN
en-wikipedia-org-3485	178	11	that	that	IN
en-wikipedia-org-3485	178	12	dopamine	dopamine	NN
en-wikipedia-org-3485	178	13	is	be	VBZ
en-wikipedia-org-3485	178	14	one	one	CD
en-wikipedia-org-3485	178	15	of	of	IN
en-wikipedia-org-3485	178	16	the	the	DT
en-wikipedia-org-3485	178	17	main	main	JJ
en-wikipedia-org-3485	178	18	chemicals	chemical	NNS
en-wikipedia-org-3485	178	19	aiding	aid	VBG
en-wikipedia-org-3485	178	20	neural	neural	JJ
en-wikipedia-org-3485	178	21	signaling	signal	VBG
en-wikipedia-org-3485	178	22	in	in	IN
en-wikipedia-org-3485	178	23	these	these	DT
en-wikipedia-org-3485	178	24	regions	region	NNS
en-wikipedia-org-3485	178	25	,	,	,
en-wikipedia-org-3485	178	26	and	and	CC
en-wikipedia-org-3485	178	27	dopamine	dopamine	NN
en-wikipedia-org-3485	178	28	was	be	VBD
en-wikipedia-org-3485	178	29	suggested	suggest	VBN
en-wikipedia-org-3485	178	30	to	to	TO
en-wikipedia-org-3485	178	31	be	be	VB
en-wikipedia-org-3485	178	32	the	the	DT
en-wikipedia-org-3485	178	33	brain	brain	NN
en-wikipedia-org-3485	178	34	's	's	POS
en-wikipedia-org-3485	178	35	"	"	``
en-wikipedia-org-3485	178	36	pleasure	pleasure	NN
en-wikipedia-org-3485	178	37	chemical	chemical	NN
en-wikipedia-org-3485	178	38	"	"	''
en-wikipedia-org-3485	178	39	.	.	.
en-wikipedia-org-3485	179	1	[	[	-LRB-
en-wikipedia-org-3485	179	2	97	97	CD
en-wikipedia-org-3485	179	3	]	]	-RRB-
en-wikipedia-org-3485	179	4	Ivan	Ivan	NNP
en-wikipedia-org-3485	179	5	Pavlov	Pavlov	NNP
en-wikipedia-org-3485	179	6	was	be	VBD
en-wikipedia-org-3485	179	7	a	a	DT
en-wikipedia-org-3485	179	8	psychologist	psychologist	NN
en-wikipedia-org-3485	179	9	who	who	WP
en-wikipedia-org-3485	179	10	used	use	VBD
en-wikipedia-org-3485	179	11	the	the	DT
en-wikipedia-org-3485	179	12	reward	reward	NN
en-wikipedia-org-3485	179	13	system	system	NN
en-wikipedia-org-3485	179	14	to	to	TO
en-wikipedia-org-3485	179	15	study	study	VB
en-wikipedia-org-3485	179	16	classical	classical	JJ
en-wikipedia-org-3485	179	17	conditioning	conditioning	NN
en-wikipedia-org-3485	179	18	.	.	.
en-wikipedia-org-3485	180	1	Pavlov	Pavlov	NNP
en-wikipedia-org-3485	180	2	used	use	VBD
en-wikipedia-org-3485	180	3	the	the	DT
en-wikipedia-org-3485	180	4	reward	reward	NN
en-wikipedia-org-3485	180	5	system	system	NN
en-wikipedia-org-3485	180	6	by	by	IN
en-wikipedia-org-3485	180	7	rewarding	reward	VBG
en-wikipedia-org-3485	180	8	dogs	dog	NNS
en-wikipedia-org-3485	180	9	with	with	IN
en-wikipedia-org-3485	180	10	food	food	NN
en-wikipedia-org-3485	180	11	after	after	IN
en-wikipedia-org-3485	180	12	they	-PRON-	PRP
en-wikipedia-org-3485	180	13	had	have	VBD
en-wikipedia-org-3485	180	14	heard	hear	VBN
en-wikipedia-org-3485	180	15	a	a	DT
en-wikipedia-org-3485	180	16	bell	bell	NN
en-wikipedia-org-3485	180	17	or	or	CC
en-wikipedia-org-3485	180	18	another	another	DT
en-wikipedia-org-3485	180	19	stimulus	stimulus	NN
en-wikipedia-org-3485	180	20	.	.	.
en-wikipedia-org-3485	181	1	Pavlov	Pavlov	NNP
en-wikipedia-org-3485	181	2	was	be	VBD
en-wikipedia-org-3485	181	3	rewarding	reward	VBG
en-wikipedia-org-3485	181	4	the	the	DT
en-wikipedia-org-3485	181	5	dogs	dog	NNS
en-wikipedia-org-3485	181	6	so	so	IN
en-wikipedia-org-3485	181	7	that	that	IN
en-wikipedia-org-3485	181	8	the	the	DT
en-wikipedia-org-3485	181	9	dogs	dog	NNS
en-wikipedia-org-3485	181	10	associated	associate	VBD
en-wikipedia-org-3485	181	11	food	food	NN
en-wikipedia-org-3485	181	12	,	,	,
en-wikipedia-org-3485	181	13	the	the	DT
en-wikipedia-org-3485	181	14	reward	reward	NN
en-wikipedia-org-3485	181	15	,	,	,
en-wikipedia-org-3485	181	16	with	with	IN
en-wikipedia-org-3485	181	17	the	the	DT
en-wikipedia-org-3485	181	18	bell	bell	NN
en-wikipedia-org-3485	181	19	,	,	,
en-wikipedia-org-3485	181	20	the	the	DT
en-wikipedia-org-3485	181	21	stimulus	stimulus	NN
en-wikipedia-org-3485	181	22	.	.	.
en-wikipedia-org-3485	182	1	[	[	-LRB-
en-wikipedia-org-3485	182	2	98	98	CD
en-wikipedia-org-3485	182	3	]	]	-RRB-
en-wikipedia-org-3485	182	4	Edward	Edward	NNP
en-wikipedia-org-3485	182	5	L.	L.	NNP
en-wikipedia-org-3485	182	6	Thorndike	Thorndike	NNP
en-wikipedia-org-3485	182	7	used	use	VBD
en-wikipedia-org-3485	182	8	the	the	DT
en-wikipedia-org-3485	182	9	reward	reward	NN
en-wikipedia-org-3485	182	10	system	system	NN
en-wikipedia-org-3485	182	11	to	to	TO
en-wikipedia-org-3485	182	12	study	study	VB
en-wikipedia-org-3485	182	13	operant	operant	JJ
en-wikipedia-org-3485	182	14	conditioning	conditioning	NN
en-wikipedia-org-3485	182	15	.	.	.
en-wikipedia-org-3485	183	1	He	-PRON-	PRP
en-wikipedia-org-3485	183	2	began	begin	VBD
en-wikipedia-org-3485	183	3	by	by	IN
en-wikipedia-org-3485	183	4	putting	put	VBG
en-wikipedia-org-3485	183	5	cats	cat	NNS
en-wikipedia-org-3485	183	6	in	in	IN
en-wikipedia-org-3485	183	7	a	a	DT
en-wikipedia-org-3485	183	8	puzzle	puzzle	NN
en-wikipedia-org-3485	183	9	box	box	NN
en-wikipedia-org-3485	183	10	and	and	CC
en-wikipedia-org-3485	183	11	placing	place	VBG
en-wikipedia-org-3485	183	12	food	food	NN
en-wikipedia-org-3485	183	13	outside	outside	IN
en-wikipedia-org-3485	183	14	of	of	IN
en-wikipedia-org-3485	183	15	the	the	DT
en-wikipedia-org-3485	183	16	box	box	NN
en-wikipedia-org-3485	183	17	so	so	IN
en-wikipedia-org-3485	183	18	that	that	IN
en-wikipedia-org-3485	183	19	the	the	DT
en-wikipedia-org-3485	183	20	cat	cat	NN
en-wikipedia-org-3485	183	21	wanted	want	VBD
en-wikipedia-org-3485	183	22	to	to	TO
en-wikipedia-org-3485	183	23	escape	escape	VB
en-wikipedia-org-3485	183	24	.	.	.
en-wikipedia-org-3485	184	1	The	the	DT
en-wikipedia-org-3485	184	2	cats	cat	NNS
en-wikipedia-org-3485	184	3	worked	work	VBD
en-wikipedia-org-3485	184	4	to	to	TO
en-wikipedia-org-3485	184	5	get	get	VB
en-wikipedia-org-3485	184	6	out	out	IN
en-wikipedia-org-3485	184	7	of	of	IN
en-wikipedia-org-3485	184	8	the	the	DT
en-wikipedia-org-3485	184	9	puzzle	puzzle	NN
en-wikipedia-org-3485	184	10	box	box	NN
en-wikipedia-org-3485	184	11	to	to	TO
en-wikipedia-org-3485	184	12	get	get	VB
en-wikipedia-org-3485	184	13	to	to	IN
en-wikipedia-org-3485	184	14	the	the	DT
en-wikipedia-org-3485	184	15	food	food	NN
en-wikipedia-org-3485	184	16	.	.	.
en-wikipedia-org-3485	185	1	Although	although	IN
en-wikipedia-org-3485	185	2	the	the	DT
en-wikipedia-org-3485	185	3	cats	cat	NNS
en-wikipedia-org-3485	185	4	ate	eat	VBD
en-wikipedia-org-3485	185	5	the	the	DT
en-wikipedia-org-3485	185	6	food	food	NN
en-wikipedia-org-3485	185	7	after	after	IN
en-wikipedia-org-3485	185	8	they	-PRON-	PRP
en-wikipedia-org-3485	185	9	escaped	escape	VBD
en-wikipedia-org-3485	185	10	the	the	DT
en-wikipedia-org-3485	185	11	box	box	NN
en-wikipedia-org-3485	185	12	,	,	,
en-wikipedia-org-3485	185	13	Thorndike	Thorndike	NNP
en-wikipedia-org-3485	185	14	learned	learn	VBD
en-wikipedia-org-3485	185	15	that	that	IN
en-wikipedia-org-3485	185	16	the	the	DT
en-wikipedia-org-3485	185	17	cats	cat	NNS
en-wikipedia-org-3485	185	18	attempted	attempt	VBD
en-wikipedia-org-3485	185	19	to	to	TO
en-wikipedia-org-3485	185	20	escape	escape	VB
en-wikipedia-org-3485	185	21	the	the	DT
en-wikipedia-org-3485	185	22	box	box	NN
en-wikipedia-org-3485	185	23	without	without	IN
en-wikipedia-org-3485	185	24	the	the	DT
en-wikipedia-org-3485	185	25	reward	reward	NN
en-wikipedia-org-3485	185	26	of	of	IN
en-wikipedia-org-3485	185	27	food	food	NN
en-wikipedia-org-3485	185	28	.	.	.
en-wikipedia-org-3485	186	1	Thorndike	Thorndike	NNP
en-wikipedia-org-3485	186	2	used	use	VBD
en-wikipedia-org-3485	186	3	the	the	DT
en-wikipedia-org-3485	186	4	rewards	reward	NNS
en-wikipedia-org-3485	186	5	of	of	IN
en-wikipedia-org-3485	186	6	food	food	NN
en-wikipedia-org-3485	186	7	and	and	CC
en-wikipedia-org-3485	186	8	freedom	freedom	NN
en-wikipedia-org-3485	186	9	to	to	TO
en-wikipedia-org-3485	186	10	stimulate	stimulate	VB
en-wikipedia-org-3485	186	11	the	the	DT
en-wikipedia-org-3485	186	12	reward	reward	NN
en-wikipedia-org-3485	186	13	system	system	NN
en-wikipedia-org-3485	186	14	of	of	IN
en-wikipedia-org-3485	186	15	the	the	DT
en-wikipedia-org-3485	186	16	cats	cat	NNS
en-wikipedia-org-3485	186	17	.	.	.
en-wikipedia-org-3485	187	1	Thorndike	Thorndike	NNP
en-wikipedia-org-3485	187	2	used	use	VBD
en-wikipedia-org-3485	187	3	this	this	DT
en-wikipedia-org-3485	187	4	to	to	TO
en-wikipedia-org-3485	187	5	see	see	VB
en-wikipedia-org-3485	187	6	how	how	WRB
en-wikipedia-org-3485	187	7	the	the	DT
en-wikipedia-org-3485	187	8	cats	cat	NNS
en-wikipedia-org-3485	187	9	learned	learn	VBD
en-wikipedia-org-3485	187	10	to	to	TO
en-wikipedia-org-3485	187	11	escape	escape	VB
en-wikipedia-org-3485	187	12	the	the	DT
en-wikipedia-org-3485	187	13	box	box	NN
en-wikipedia-org-3485	187	14	.	.	.
en-wikipedia-org-3485	188	1	[	[	-LRB-
en-wikipedia-org-3485	188	2	99	99	CD
en-wikipedia-org-3485	188	3	]	]	-RRB-
en-wikipedia-org-3485	188	4	Other	other	JJ
en-wikipedia-org-3485	188	5	species[edit	species[edit	,
en-wikipedia-org-3485	188	6	]	]	-RRB-
en-wikipedia-org-3485	188	7	Animals	animal	NNS
en-wikipedia-org-3485	188	8	quickly	quickly	RB
en-wikipedia-org-3485	188	9	learn	learn	VBP
en-wikipedia-org-3485	188	10	to	to	TO
en-wikipedia-org-3485	188	11	press	press	VB
en-wikipedia-org-3485	188	12	a	a	DT
en-wikipedia-org-3485	188	13	bar	bar	NN
en-wikipedia-org-3485	188	14	to	to	TO
en-wikipedia-org-3485	188	15	obtain	obtain	VB
en-wikipedia-org-3485	188	16	an	an	DT
en-wikipedia-org-3485	188	17	injection	injection	NN
en-wikipedia-org-3485	188	18	of	of	IN
en-wikipedia-org-3485	188	19	opiates	opiate	NNS
en-wikipedia-org-3485	188	20	directly	directly	RB
en-wikipedia-org-3485	188	21	into	into	IN
en-wikipedia-org-3485	188	22	the	the	DT
en-wikipedia-org-3485	188	23	midbrain	midbrain	NN
en-wikipedia-org-3485	188	24	tegmentum	tegmentum	NN
en-wikipedia-org-3485	188	25	or	or	CC
en-wikipedia-org-3485	188	26	the	the	DT
en-wikipedia-org-3485	188	27	nucleus	nucleus	NN
en-wikipedia-org-3485	188	28	accumbens	accumben	NNS
en-wikipedia-org-3485	188	29	.	.	.
en-wikipedia-org-3485	189	1	The	the	DT
en-wikipedia-org-3485	189	2	same	same	JJ
en-wikipedia-org-3485	189	3	animals	animal	NNS
en-wikipedia-org-3485	189	4	do	do	VBP
en-wikipedia-org-3485	189	5	not	not	RB
en-wikipedia-org-3485	189	6	work	work	VB
en-wikipedia-org-3485	189	7	to	to	TO
en-wikipedia-org-3485	189	8	obtain	obtain	VB
en-wikipedia-org-3485	189	9	the	the	DT
en-wikipedia-org-3485	189	10	opiates	opiates	NNPS
en-wikipedia-org-3485	189	11	if	if	IN
en-wikipedia-org-3485	189	12	the	the	DT
en-wikipedia-org-3485	189	13	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	189	14	neurons	neuron	NNS
en-wikipedia-org-3485	189	15	of	of	IN
en-wikipedia-org-3485	189	16	the	the	DT
en-wikipedia-org-3485	189	17	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	189	18	pathway	pathway	NN
en-wikipedia-org-3485	189	19	are	be	VBP
en-wikipedia-org-3485	189	20	inactivated	inactivate	VBN
en-wikipedia-org-3485	189	21	.	.	.
en-wikipedia-org-3485	190	1	In	in	IN
en-wikipedia-org-3485	190	2	this	this	DT
en-wikipedia-org-3485	190	3	perspective	perspective	NN
en-wikipedia-org-3485	190	4	,	,	,
en-wikipedia-org-3485	190	5	animals	animal	NNS
en-wikipedia-org-3485	190	6	,	,	,
en-wikipedia-org-3485	190	7	like	like	IN
en-wikipedia-org-3485	190	8	humans	human	NNS
en-wikipedia-org-3485	190	9	,	,	,
en-wikipedia-org-3485	190	10	engage	engage	VBP
en-wikipedia-org-3485	190	11	in	in	IN
en-wikipedia-org-3485	190	12	behaviors	behavior	NNS
en-wikipedia-org-3485	190	13	that	that	WDT
en-wikipedia-org-3485	190	14	increase	increase	VBP
en-wikipedia-org-3485	190	15	dopamine	dopamine	NN
en-wikipedia-org-3485	190	16	release	release	NN
en-wikipedia-org-3485	190	17	.	.	.
en-wikipedia-org-3485	191	1	Kent	Kent	NNP
en-wikipedia-org-3485	191	2	Berridge	Berridge	NNP
en-wikipedia-org-3485	191	3	,	,	,
en-wikipedia-org-3485	191	4	a	a	DT
en-wikipedia-org-3485	191	5	researcher	researcher	NN
en-wikipedia-org-3485	191	6	in	in	IN
en-wikipedia-org-3485	191	7	affective	affective	JJ
en-wikipedia-org-3485	191	8	neuroscience	neuroscience	NN
en-wikipedia-org-3485	191	9	,	,	,
en-wikipedia-org-3485	191	10	found	find	VBD
en-wikipedia-org-3485	191	11	that	that	IN
en-wikipedia-org-3485	191	12	sweet	sweet	JJ
en-wikipedia-org-3485	191	13	(	(	-LRB-
en-wikipedia-org-3485	191	14	liked	like	VBN
en-wikipedia-org-3485	191	15	 	 	_SP
en-wikipedia-org-3485	191	16	)	)	-RRB-
en-wikipedia-org-3485	191	17	and	and	CC
en-wikipedia-org-3485	191	18	bitter	bitter	JJ
en-wikipedia-org-3485	191	19	(	(	-LRB-
en-wikipedia-org-3485	191	20	disliked	dislike	VBN
en-wikipedia-org-3485	191	21	 	 	_SP
en-wikipedia-org-3485	191	22	)	)	-RRB-
en-wikipedia-org-3485	191	23	tastes	taste	NNS
en-wikipedia-org-3485	191	24	produced	produce	VBN
en-wikipedia-org-3485	191	25	distinct	distinct	JJ
en-wikipedia-org-3485	191	26	orofacial	orofacial	JJ
en-wikipedia-org-3485	191	27	expressions	expression	NNS
en-wikipedia-org-3485	191	28	,	,	,
en-wikipedia-org-3485	191	29	and	and	CC
en-wikipedia-org-3485	191	30	these	these	DT
en-wikipedia-org-3485	191	31	expressions	expression	NNS
en-wikipedia-org-3485	191	32	were	be	VBD
en-wikipedia-org-3485	191	33	similarly	similarly	RB
en-wikipedia-org-3485	191	34	displayed	display	VBN
en-wikipedia-org-3485	191	35	by	by	IN
en-wikipedia-org-3485	191	36	human	human	JJ
en-wikipedia-org-3485	191	37	newborns	newborn	NNS
en-wikipedia-org-3485	191	38	,	,	,
en-wikipedia-org-3485	191	39	orangutans	orangutan	NNS
en-wikipedia-org-3485	191	40	,	,	,
en-wikipedia-org-3485	191	41	and	and	CC
en-wikipedia-org-3485	191	42	rats	rat	NNS
en-wikipedia-org-3485	191	43	.	.	.
en-wikipedia-org-3485	192	1	This	this	DT
en-wikipedia-org-3485	192	2	was	be	VBD
en-wikipedia-org-3485	192	3	evidence	evidence	NN
en-wikipedia-org-3485	192	4	that	that	IN
en-wikipedia-org-3485	192	5	pleasure	pleasure	NN
en-wikipedia-org-3485	192	6	(	(	-LRB-
en-wikipedia-org-3485	192	7	specifically	specifically	RB
en-wikipedia-org-3485	192	8	,	,	,
en-wikipedia-org-3485	192	9	liking	like	VBG
en-wikipedia-org-3485	192	10	)	)	-RRB-
en-wikipedia-org-3485	192	11	has	have	VBZ
en-wikipedia-org-3485	192	12	objective	objective	JJ
en-wikipedia-org-3485	192	13	features	feature	NNS
en-wikipedia-org-3485	192	14	and	and	CC
en-wikipedia-org-3485	192	15	was	be	VBD
en-wikipedia-org-3485	192	16	essentially	essentially	RB
en-wikipedia-org-3485	192	17	the	the	DT
en-wikipedia-org-3485	192	18	same	same	JJ
en-wikipedia-org-3485	192	19	across	across	IN
en-wikipedia-org-3485	192	20	various	various	JJ
en-wikipedia-org-3485	192	21	animal	animal	NN
en-wikipedia-org-3485	192	22	species	specie	NNS
en-wikipedia-org-3485	192	23	.	.	.
en-wikipedia-org-3485	193	1	Most	Most	JJS
en-wikipedia-org-3485	193	2	neuroscience	neuroscience	JJ
en-wikipedia-org-3485	193	3	studies	study	NNS
en-wikipedia-org-3485	193	4	have	have	VBP
en-wikipedia-org-3485	193	5	shown	show	VBN
en-wikipedia-org-3485	193	6	that	that	IN
en-wikipedia-org-3485	193	7	the	the	DT
en-wikipedia-org-3485	193	8	more	more	JJR
en-wikipedia-org-3485	193	9	dopamine	dopamine	NN
en-wikipedia-org-3485	193	10	released	release	VBN
en-wikipedia-org-3485	193	11	by	by	IN
en-wikipedia-org-3485	193	12	the	the	DT
en-wikipedia-org-3485	193	13	reward	reward	NN
en-wikipedia-org-3485	193	14	,	,	,
en-wikipedia-org-3485	193	15	the	the	DT
en-wikipedia-org-3485	193	16	more	more	RBR
en-wikipedia-org-3485	193	17	effective	effective	JJ
en-wikipedia-org-3485	193	18	the	the	DT
en-wikipedia-org-3485	193	19	reward	reward	NN
en-wikipedia-org-3485	193	20	is	be	VBZ
en-wikipedia-org-3485	193	21	.	.	.
en-wikipedia-org-3485	194	1	This	this	DT
en-wikipedia-org-3485	194	2	is	be	VBZ
en-wikipedia-org-3485	194	3	called	call	VBN
en-wikipedia-org-3485	194	4	the	the	DT
en-wikipedia-org-3485	194	5	hedonic	hedonic	JJ
en-wikipedia-org-3485	194	6	impact	impact	NN
en-wikipedia-org-3485	194	7	,	,	,
en-wikipedia-org-3485	194	8	which	which	WDT
en-wikipedia-org-3485	194	9	can	can	MD
en-wikipedia-org-3485	194	10	be	be	VB
en-wikipedia-org-3485	194	11	changed	change	VBN
en-wikipedia-org-3485	194	12	by	by	IN
en-wikipedia-org-3485	194	13	the	the	DT
en-wikipedia-org-3485	194	14	effort	effort	NN
en-wikipedia-org-3485	194	15	for	for	IN
en-wikipedia-org-3485	194	16	the	the	DT
en-wikipedia-org-3485	194	17	reward	reward	NN
en-wikipedia-org-3485	194	18	and	and	CC
en-wikipedia-org-3485	194	19	the	the	DT
en-wikipedia-org-3485	194	20	reward	reward	NN
en-wikipedia-org-3485	194	21	itself	-PRON-	PRP
en-wikipedia-org-3485	194	22	.	.	.
en-wikipedia-org-3485	195	1	Berridge	Berridge	NNP
en-wikipedia-org-3485	195	2	discovered	discover	VBD
en-wikipedia-org-3485	195	3	that	that	IN
en-wikipedia-org-3485	195	4	blocking	block	VBG
en-wikipedia-org-3485	195	5	dopamine	dopamine	NN
en-wikipedia-org-3485	195	6	systems	system	NNS
en-wikipedia-org-3485	195	7	did	do	VBD
en-wikipedia-org-3485	195	8	not	not	RB
en-wikipedia-org-3485	195	9	seem	seem	VB
en-wikipedia-org-3485	195	10	to	to	TO
en-wikipedia-org-3485	195	11	change	change	VB
en-wikipedia-org-3485	195	12	the	the	DT
en-wikipedia-org-3485	195	13	positive	positive	JJ
en-wikipedia-org-3485	195	14	reaction	reaction	NN
en-wikipedia-org-3485	195	15	to	to	IN
en-wikipedia-org-3485	195	16	something	something	NN
en-wikipedia-org-3485	195	17	sweet	sweet	JJ
en-wikipedia-org-3485	195	18	(	(	-LRB-
en-wikipedia-org-3485	195	19	as	as	IN
en-wikipedia-org-3485	195	20	measured	measure	VBN
en-wikipedia-org-3485	195	21	by	by	IN
en-wikipedia-org-3485	195	22	facial	facial	JJ
en-wikipedia-org-3485	195	23	expression	expression	NN
en-wikipedia-org-3485	195	24	)	)	-RRB-
en-wikipedia-org-3485	195	25	.	.	.
en-wikipedia-org-3485	196	1	In	in	IN
en-wikipedia-org-3485	196	2	other	other	JJ
en-wikipedia-org-3485	196	3	words	word	NNS
en-wikipedia-org-3485	196	4	,	,	,
en-wikipedia-org-3485	196	5	the	the	DT
en-wikipedia-org-3485	196	6	hedonic	hedonic	JJ
en-wikipedia-org-3485	196	7	impact	impact	NN
en-wikipedia-org-3485	196	8	did	do	VBD
en-wikipedia-org-3485	196	9	not	not	RB
en-wikipedia-org-3485	196	10	change	change	VB
en-wikipedia-org-3485	196	11	based	base	VBN
en-wikipedia-org-3485	196	12	on	on	IN
en-wikipedia-org-3485	196	13	the	the	DT
en-wikipedia-org-3485	196	14	amount	amount	NN
en-wikipedia-org-3485	196	15	of	of	IN
en-wikipedia-org-3485	196	16	sugar	sugar	NN
en-wikipedia-org-3485	196	17	.	.	.
en-wikipedia-org-3485	197	1	This	this	DT
en-wikipedia-org-3485	197	2	discounted	discount	VBD
en-wikipedia-org-3485	197	3	the	the	DT
en-wikipedia-org-3485	197	4	conventional	conventional	JJ
en-wikipedia-org-3485	197	5	assumption	assumption	NN
en-wikipedia-org-3485	197	6	that	that	IN
en-wikipedia-org-3485	197	7	dopamine	dopamine	NN
en-wikipedia-org-3485	197	8	mediates	mediate	VBZ
en-wikipedia-org-3485	197	9	pleasure	pleasure	NN
en-wikipedia-org-3485	197	10	.	.	.
en-wikipedia-org-3485	198	1	Even	even	RB
en-wikipedia-org-3485	198	2	with	with	IN
en-wikipedia-org-3485	198	3	more	more	RBR
en-wikipedia-org-3485	198	4	-	-	HYPH
en-wikipedia-org-3485	198	5	intense	intense	JJ
en-wikipedia-org-3485	198	6	dopamine	dopamine	NN
en-wikipedia-org-3485	198	7	alterations	alteration	NNS
en-wikipedia-org-3485	198	8	,	,	,
en-wikipedia-org-3485	198	9	the	the	DT
en-wikipedia-org-3485	198	10	data	datum	NNS
en-wikipedia-org-3485	198	11	seemed	seem	VBD
en-wikipedia-org-3485	198	12	to	to	TO
en-wikipedia-org-3485	198	13	remain	remain	VB
en-wikipedia-org-3485	198	14	constant	constant	JJ
en-wikipedia-org-3485	198	15	.	.	.
en-wikipedia-org-3485	199	1	[	[	-LRB-
en-wikipedia-org-3485	199	2	100	100	CD
en-wikipedia-org-3485	199	3	]	]	-RRB-
en-wikipedia-org-3485	199	4	However	however	RB
en-wikipedia-org-3485	199	5	,	,	,
en-wikipedia-org-3485	199	6	a	a	DT
en-wikipedia-org-3485	199	7	clinical	clinical	JJ
en-wikipedia-org-3485	199	8	study	study	NN
en-wikipedia-org-3485	199	9	from	from	IN
en-wikipedia-org-3485	199	10	January	January	NNP
en-wikipedia-org-3485	199	11	2019	2019	CD
en-wikipedia-org-3485	199	12	that	that	WDT
en-wikipedia-org-3485	199	13	assessed	assess	VBD
en-wikipedia-org-3485	199	14	the	the	DT
en-wikipedia-org-3485	199	15	effect	effect	NN
en-wikipedia-org-3485	199	16	of	of	IN
en-wikipedia-org-3485	199	17	a	a	DT
en-wikipedia-org-3485	199	18	dopamine	dopamine	NN
en-wikipedia-org-3485	199	19	precursor	precursor	NN
en-wikipedia-org-3485	199	20	(	(	-LRB-
en-wikipedia-org-3485	199	21	levodopa	levodopa	NNP
en-wikipedia-org-3485	199	22	)	)	-RRB-
en-wikipedia-org-3485	199	23	,	,	,
en-wikipedia-org-3485	199	24	antagonist	antagonist	NN
en-wikipedia-org-3485	199	25	(	(	-LRB-
en-wikipedia-org-3485	199	26	risperidone	risperidone	NNP
en-wikipedia-org-3485	199	27	)	)	-RRB-
en-wikipedia-org-3485	199	28	,	,	,
en-wikipedia-org-3485	199	29	and	and	CC
en-wikipedia-org-3485	199	30	a	a	DT
en-wikipedia-org-3485	199	31	placebo	placebo	NN
en-wikipedia-org-3485	199	32	on	on	IN
en-wikipedia-org-3485	199	33	reward	reward	NN
en-wikipedia-org-3485	199	34	responses	response	NNS
en-wikipedia-org-3485	199	35	to	to	IN
en-wikipedia-org-3485	199	36	music	music	NN
en-wikipedia-org-3485	199	37	 	  	_SP
en-wikipedia-org-3485	199	38	–	–	:
en-wikipedia-org-3485	199	39	including	include	VBG
en-wikipedia-org-3485	199	40	the	the	DT
en-wikipedia-org-3485	199	41	degree	degree	NN
en-wikipedia-org-3485	199	42	of	of	IN
en-wikipedia-org-3485	199	43	pleasure	pleasure	NN
en-wikipedia-org-3485	199	44	experienced	experience	VBN
en-wikipedia-org-3485	199	45	during	during	IN
en-wikipedia-org-3485	199	46	musical	musical	JJ
en-wikipedia-org-3485	199	47	chills	chill	NNS
en-wikipedia-org-3485	199	48	,	,	,
en-wikipedia-org-3485	199	49	as	as	IN
en-wikipedia-org-3485	199	50	measured	measure	VBN
en-wikipedia-org-3485	199	51	by	by	IN
en-wikipedia-org-3485	199	52	changes	change	NNS
en-wikipedia-org-3485	199	53	in	in	IN
en-wikipedia-org-3485	199	54	electrodermal	electrodermal	JJ
en-wikipedia-org-3485	199	55	activity	activity	NN
en-wikipedia-org-3485	199	56	as	as	RB
en-wikipedia-org-3485	199	57	well	well	RB
en-wikipedia-org-3485	199	58	as	as	IN
en-wikipedia-org-3485	199	59	subjective	subjective	JJ
en-wikipedia-org-3485	199	60	ratings	rating	NNS
en-wikipedia-org-3485	199	61	 	  	_SP
en-wikipedia-org-3485	199	62	–	–	:
en-wikipedia-org-3485	199	63	found	find	VBD
en-wikipedia-org-3485	199	64	that	that	IN
en-wikipedia-org-3485	199	65	the	the	DT
en-wikipedia-org-3485	199	66	manipulation	manipulation	NN
en-wikipedia-org-3485	199	67	of	of	IN
en-wikipedia-org-3485	199	68	dopamine	dopamine	NN
en-wikipedia-org-3485	199	69	neurotransmission	neurotransmission	NN
en-wikipedia-org-3485	199	70	bidirectionally	bidirectionally	RB
en-wikipedia-org-3485	199	71	regulates	regulate	VBZ
en-wikipedia-org-3485	199	72	pleasure	pleasure	NN
en-wikipedia-org-3485	199	73	cognition	cognition	NN
en-wikipedia-org-3485	199	74	(	(	-LRB-
en-wikipedia-org-3485	199	75	specifically	specifically	RB
en-wikipedia-org-3485	199	76	,	,	,
en-wikipedia-org-3485	199	77	the	the	DT
en-wikipedia-org-3485	199	78	hedonic	hedonic	JJ
en-wikipedia-org-3485	199	79	impact	impact	NN
en-wikipedia-org-3485	199	80	of	of	IN
en-wikipedia-org-3485	199	81	music	music	NN
en-wikipedia-org-3485	199	82	)	)	-RRB-
en-wikipedia-org-3485	199	83	in	in	IN
en-wikipedia-org-3485	199	84	human	human	JJ
en-wikipedia-org-3485	199	85	subjects	subject	NNS
en-wikipedia-org-3485	199	86	.	.	.
en-wikipedia-org-3485	200	1	[	[	-LRB-
en-wikipedia-org-3485	200	2	101][102	101][102	LS
en-wikipedia-org-3485	200	3	]	]	-RRB-
en-wikipedia-org-3485	200	4	This	this	DT
en-wikipedia-org-3485	200	5	research	research	NN
en-wikipedia-org-3485	200	6	demonstrated	demonstrate	VBD
en-wikipedia-org-3485	200	7	that	that	IN
en-wikipedia-org-3485	200	8	increased	increase	VBN
en-wikipedia-org-3485	200	9	dopamine	dopamine	NN
en-wikipedia-org-3485	200	10	neurotransmission	neurotransmission	NN
en-wikipedia-org-3485	200	11	acts	act	VBZ
en-wikipedia-org-3485	200	12	as	as	IN
en-wikipedia-org-3485	200	13	a	a	DT
en-wikipedia-org-3485	200	14	sine	sine	NN
en-wikipedia-org-3485	200	15	qua	qua	NN
en-wikipedia-org-3485	200	16	non	non	JJ
en-wikipedia-org-3485	200	17	condition	condition	NN
en-wikipedia-org-3485	200	18	for	for	IN
en-wikipedia-org-3485	200	19	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	200	20	hedonic	hedonic	JJ
en-wikipedia-org-3485	200	21	reactions	reaction	NNS
en-wikipedia-org-3485	200	22	to	to	IN
en-wikipedia-org-3485	200	23	music	music	NN
en-wikipedia-org-3485	200	24	in	in	IN
en-wikipedia-org-3485	200	25	humans	human	NNS
en-wikipedia-org-3485	200	26	.	.	.
en-wikipedia-org-3485	201	1	[	[	-LRB-
en-wikipedia-org-3485	201	2	101][102	101][102	CD
en-wikipedia-org-3485	201	3	]	]	-RRB-
en-wikipedia-org-3485	201	4	Berridge	Berridge	NNP
en-wikipedia-org-3485	201	5	developed	develop	VBD
en-wikipedia-org-3485	201	6	the	the	DT
en-wikipedia-org-3485	201	7	incentive	incentive	NN
en-wikipedia-org-3485	201	8	salience	salience	NN
en-wikipedia-org-3485	201	9	hypothesis	hypothesis	NN
en-wikipedia-org-3485	201	10	to	to	TO
en-wikipedia-org-3485	201	11	address	address	VB
en-wikipedia-org-3485	201	12	the	the	DT
en-wikipedia-org-3485	201	13	wanting	want	VBG
en-wikipedia-org-3485	201	14	aspect	aspect	NN
en-wikipedia-org-3485	201	15	of	of	IN
en-wikipedia-org-3485	201	16	rewards	reward	NNS
en-wikipedia-org-3485	201	17	.	.	.
en-wikipedia-org-3485	202	1	It	-PRON-	PRP
en-wikipedia-org-3485	202	2	explains	explain	VBZ
en-wikipedia-org-3485	202	3	the	the	DT
en-wikipedia-org-3485	202	4	compulsive	compulsive	JJ
en-wikipedia-org-3485	202	5	use	use	NN
en-wikipedia-org-3485	202	6	of	of	IN
en-wikipedia-org-3485	202	7	drugs	drug	NNS
en-wikipedia-org-3485	202	8	by	by	IN
en-wikipedia-org-3485	202	9	drug	drug	NN
en-wikipedia-org-3485	202	10	addicts	addict	NNS
en-wikipedia-org-3485	202	11	even	even	RB
en-wikipedia-org-3485	202	12	when	when	WRB
en-wikipedia-org-3485	202	13	the	the	DT
en-wikipedia-org-3485	202	14	drug	drug	NN
en-wikipedia-org-3485	202	15	no	no	RB
en-wikipedia-org-3485	202	16	longer	long	RBR
en-wikipedia-org-3485	202	17	produces	produce	VBZ
en-wikipedia-org-3485	202	18	euphoria	euphoria	NN
en-wikipedia-org-3485	202	19	,	,	,
en-wikipedia-org-3485	202	20	and	and	CC
en-wikipedia-org-3485	202	21	the	the	DT
en-wikipedia-org-3485	202	22	cravings	craving	NNS
en-wikipedia-org-3485	202	23	experienced	experience	VBD
en-wikipedia-org-3485	202	24	even	even	RB
en-wikipedia-org-3485	202	25	after	after	IN
en-wikipedia-org-3485	202	26	the	the	DT
en-wikipedia-org-3485	202	27	individual	individual	NN
en-wikipedia-org-3485	202	28	has	have	VBZ
en-wikipedia-org-3485	202	29	finished	finish	VBN
en-wikipedia-org-3485	202	30	going	go	VBG
en-wikipedia-org-3485	202	31	through	through	IN
en-wikipedia-org-3485	202	32	withdrawal	withdrawal	NN
en-wikipedia-org-3485	202	33	.	.	.
en-wikipedia-org-3485	203	1	Some	some	DT
en-wikipedia-org-3485	203	2	addicts	addict	NNS
en-wikipedia-org-3485	203	3	respond	respond	VBP
en-wikipedia-org-3485	203	4	to	to	IN
en-wikipedia-org-3485	203	5	certain	certain	JJ
en-wikipedia-org-3485	203	6	stimuli	stimulus	NNS
en-wikipedia-org-3485	203	7	involving	involve	VBG
en-wikipedia-org-3485	203	8	neural	neural	JJ
en-wikipedia-org-3485	203	9	changes	change	NNS
en-wikipedia-org-3485	203	10	caused	cause	VBN
en-wikipedia-org-3485	203	11	by	by	IN
en-wikipedia-org-3485	203	12	drugs	drug	NNS
en-wikipedia-org-3485	203	13	.	.	.
en-wikipedia-org-3485	204	1	This	this	DT
en-wikipedia-org-3485	204	2	sensitization	sensitization	NN
en-wikipedia-org-3485	204	3	in	in	IN
en-wikipedia-org-3485	204	4	the	the	DT
en-wikipedia-org-3485	204	5	brain	brain	NN
en-wikipedia-org-3485	204	6	is	be	VBZ
en-wikipedia-org-3485	204	7	similar	similar	JJ
en-wikipedia-org-3485	204	8	to	to	IN
en-wikipedia-org-3485	204	9	the	the	DT
en-wikipedia-org-3485	204	10	effect	effect	NN
en-wikipedia-org-3485	204	11	of	of	IN
en-wikipedia-org-3485	204	12	dopamine	dopamine	NN
en-wikipedia-org-3485	204	13	because	because	IN
en-wikipedia-org-3485	204	14	wanting	want	VBG
en-wikipedia-org-3485	204	15	and	and	CC
en-wikipedia-org-3485	204	16	liking	like	VBG
en-wikipedia-org-3485	204	17	reactions	reaction	NNS
en-wikipedia-org-3485	204	18	occur	occur	VBP
en-wikipedia-org-3485	204	19	.	.	.
en-wikipedia-org-3485	205	1	Human	human	JJ
en-wikipedia-org-3485	205	2	and	and	CC
en-wikipedia-org-3485	205	3	animal	animal	NN
en-wikipedia-org-3485	205	4	brains	brain	NNS
en-wikipedia-org-3485	205	5	and	and	CC
en-wikipedia-org-3485	205	6	behaviors	behavior	NNS
en-wikipedia-org-3485	205	7	experience	experience	VBP
en-wikipedia-org-3485	205	8	similar	similar	JJ
en-wikipedia-org-3485	205	9	changes	change	NNS
en-wikipedia-org-3485	205	10	regarding	regard	VBG
en-wikipedia-org-3485	205	11	reward	reward	NN
en-wikipedia-org-3485	205	12	systems	system	NNS
en-wikipedia-org-3485	205	13	because	because	IN
en-wikipedia-org-3485	205	14	these	these	DT
en-wikipedia-org-3485	205	15	systems	system	NNS
en-wikipedia-org-3485	205	16	are	be	VBP
en-wikipedia-org-3485	205	17	so	so	RB
en-wikipedia-org-3485	205	18	prominent	prominent	JJ
en-wikipedia-org-3485	205	19	.	.	.
en-wikipedia-org-3485	206	1	[	[	-LRB-
en-wikipedia-org-3485	206	2	100	100	CD
en-wikipedia-org-3485	206	3	]	]	-RRB-
en-wikipedia-org-3485	206	4	See	see	VB
en-wikipedia-org-3485	206	5	also[edit	also[edit	NFP
en-wikipedia-org-3485	206	6	]	]	-RRB-
en-wikipedia-org-3485	206	7	Carrot	Carrot	NNP
en-wikipedia-org-3485	206	8	and	and	CC
en-wikipedia-org-3485	206	9	stick	stick	VB
en-wikipedia-org-3485	206	10	Child	child	NN
en-wikipedia-org-3485	206	11	grooming	groom	VBG
en-wikipedia-org-3485	206	12	Compliance	Compliance	NNP
en-wikipedia-org-3485	206	13	(	(	-LRB-
en-wikipedia-org-3485	206	14	psychology	psychology	NN
en-wikipedia-org-3485	206	15	)	)	-RRB-
en-wikipedia-org-3485	206	16	Frisson	Frisson	NNP
en-wikipedia-org-3485	206	17	Motivation	Motivation	NNP
en-wikipedia-org-3485	206	18	Norm	Norm	NNP
en-wikipedia-org-3485	206	19	of	of	IN
en-wikipedia-org-3485	206	20	reciprocity	reciprocity	NN
en-wikipedia-org-3485	206	21	Palatability	Palatability	NNP
en-wikipedia-org-3485	206	22	Pavlovian	Pavlovian	NNP
en-wikipedia-org-3485	206	23	-	-	HYPH
en-wikipedia-org-3485	206	24	instrumental	instrumental	JJ
en-wikipedia-org-3485	206	25	transfer	transfer	NN
en-wikipedia-org-3485	206	26	References[edit	references[edit	NN
en-wikipedia-org-3485	206	27	]	]	-RRB-
en-wikipedia-org-3485	206	28	^	^	FW
en-wikipedia-org-3485	206	29	a	a	DT
en-wikipedia-org-3485	206	30	b	b	NN
en-wikipedia-org-3485	206	31	c	c	NNP
en-wikipedia-org-3485	206	32	d	d	NNP
en-wikipedia-org-3485	206	33	e	e	NNP
en-wikipedia-org-3485	206	34	f	f	NNP
en-wikipedia-org-3485	206	35	g	g	NNP
en-wikipedia-org-3485	206	36	h	h	NNP
en-wikipedia-org-3485	206	37	i	i	NN
en-wikipedia-org-3485	206	38	j	j	NNP
en-wikipedia-org-3485	206	39	k	k	NNP
en-wikipedia-org-3485	206	40	l	l	NNP
en-wikipedia-org-3485	206	41	m	m	NNP
en-wikipedia-org-3485	206	42	Schultz	Schultz	NNP
en-wikipedia-org-3485	206	43	,	,	,
en-wikipedia-org-3485	206	44	Wolfram	Wolfram	NNP
en-wikipedia-org-3485	206	45	(	(	-LRB-
en-wikipedia-org-3485	206	46	July	July	NNP
en-wikipedia-org-3485	206	47	2015	2015	CD
en-wikipedia-org-3485	206	48	)	)	-RRB-
en-wikipedia-org-3485	206	49	.	.	.
en-wikipedia-org-3485	207	1	"	"	``
en-wikipedia-org-3485	207	2	Neuronal	Neuronal	NNP
en-wikipedia-org-3485	207	3	Reward	Reward	NNP
en-wikipedia-org-3485	207	4	and	and	CC
en-wikipedia-org-3485	207	5	Decision	Decision	NNP
en-wikipedia-org-3485	207	6	Signals	Signals	NNPS
en-wikipedia-org-3485	207	7	:	:	:
en-wikipedia-org-3485	207	8	From	from	IN
en-wikipedia-org-3485	207	9	Theories	Theories	NNP
en-wikipedia-org-3485	207	10	to	to	IN
en-wikipedia-org-3485	207	11	Data	Data	NNP
en-wikipedia-org-3485	207	12	"	"	''
en-wikipedia-org-3485	207	13	.	.	.
en-wikipedia-org-3485	208	1	Physiological	Physiological	NNP
en-wikipedia-org-3485	208	2	Reviews	Reviews	NNPS
en-wikipedia-org-3485	208	3	.	.	.
en-wikipedia-org-3485	209	1	95	95	CD
en-wikipedia-org-3485	209	2	(	(	-LRB-
en-wikipedia-org-3485	209	3	3	3	CD
en-wikipedia-org-3485	209	4	)	)	-RRB-
en-wikipedia-org-3485	209	5	:	:	:
en-wikipedia-org-3485	209	6	853–951	853–951	CD
en-wikipedia-org-3485	209	7	.	.	.
en-wikipedia-org-3485	210	1	doi:10.1152	doi:10.1152	NNP
en-wikipedia-org-3485	210	2	/	/	SYM
en-wikipedia-org-3485	210	3	physrev.00023.2014	physrev.00023.2014	NNS
en-wikipedia-org-3485	210	4	.	.	.
en-wikipedia-org-3485	211	1	PMC	PMC	NNP
en-wikipedia-org-3485	211	2	 	  	_SP
en-wikipedia-org-3485	211	3	4491543	4491543	CD
en-wikipedia-org-3485	211	4	.	.	.
en-wikipedia-org-3485	212	1	PMID	PMID	NNP
en-wikipedia-org-3485	212	2	 	  	_SP
en-wikipedia-org-3485	212	3	26109341	26109341	CD
en-wikipedia-org-3485	212	4	.	.	.
en-wikipedia-org-3485	213	1	^	^	NNP
en-wikipedia-org-3485	213	2	a	a	DT
en-wikipedia-org-3485	213	3	b	b	NNP
en-wikipedia-org-3485	213	4	c	c	NNP
en-wikipedia-org-3485	213	5	d	d	NNP
en-wikipedia-org-3485	213	6	e	e	NNP
en-wikipedia-org-3485	213	7	f	f	NNP
en-wikipedia-org-3485	213	8	g	g	NNP
en-wikipedia-org-3485	213	9	h	h	NNP
en-wikipedia-org-3485	213	10	Berridge	Berridge	NNP
en-wikipedia-org-3485	213	11	KC	KC	NNP
en-wikipedia-org-3485	213	12	,	,	,
en-wikipedia-org-3485	213	13	Kringelbach	Kringelbach	NNP
en-wikipedia-org-3485	213	14	ML	ML	NNP
en-wikipedia-org-3485	213	15	(	(	-LRB-
en-wikipedia-org-3485	213	16	May	May	NNP
en-wikipedia-org-3485	213	17	2015	2015	CD
en-wikipedia-org-3485	213	18	)	)	-RRB-
en-wikipedia-org-3485	213	19	.	.	.
en-wikipedia-org-3485	214	1	"	"	``
en-wikipedia-org-3485	214	2	Pleasure	pleasure	NN
en-wikipedia-org-3485	214	3	systems	system	NNS
en-wikipedia-org-3485	214	4	in	in	IN
en-wikipedia-org-3485	214	5	the	the	DT
en-wikipedia-org-3485	214	6	brain	brain	NN
en-wikipedia-org-3485	214	7	"	"	''
en-wikipedia-org-3485	214	8	.	.	.
en-wikipedia-org-3485	215	1	Neuron	neuron	UH
en-wikipedia-org-3485	215	2	.	.	.
en-wikipedia-org-3485	216	1	86	86	CD
en-wikipedia-org-3485	216	2	(	(	-LRB-
en-wikipedia-org-3485	216	3	3	3	CD
en-wikipedia-org-3485	216	4	)	)	-RRB-
en-wikipedia-org-3485	216	5	:	:	:
en-wikipedia-org-3485	216	6	646–664	646–664	CD
en-wikipedia-org-3485	216	7	.	.	.
en-wikipedia-org-3485	217	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	217	2	/	/	SYM
en-wikipedia-org-3485	217	3	j.neuron.2015.02.018	j.neuron.2015.02.018	NNP
en-wikipedia-org-3485	217	4	.	.	.
en-wikipedia-org-3485	218	1	PMC	PMC	NNP
en-wikipedia-org-3485	218	2	 	  	_SP
en-wikipedia-org-3485	218	3	4425246	4425246	CD
en-wikipedia-org-3485	218	4	.	.	.
en-wikipedia-org-3485	219	1	PMID	PMID	NNP
en-wikipedia-org-3485	219	2	 	  	_SP
en-wikipedia-org-3485	219	3	25950633	25950633	CD
en-wikipedia-org-3485	219	4	.	.	.
en-wikipedia-org-3485	220	1	In	in	IN
en-wikipedia-org-3485	220	2	the	the	DT
en-wikipedia-org-3485	220	3	prefrontal	prefrontal	JJ
en-wikipedia-org-3485	220	4	cortex	cortex	NN
en-wikipedia-org-3485	220	5	,	,	,
en-wikipedia-org-3485	220	6	recent	recent	JJ
en-wikipedia-org-3485	220	7	evidence	evidence	NN
en-wikipedia-org-3485	220	8	indicates	indicate	VBZ
en-wikipedia-org-3485	220	9	that	that	IN
en-wikipedia-org-3485	220	10	the	the	DT
en-wikipedia-org-3485	220	11	[	[	-LRB-
en-wikipedia-org-3485	220	12	orbitofrontal	orbitofrontal	NNP
en-wikipedia-org-3485	220	13	cortex	cortex	NNP
en-wikipedia-org-3485	220	14	]	]	-RRB-
en-wikipedia-org-3485	220	15	OFC	OFC	NNP
en-wikipedia-org-3485	220	16	and	and	CC
en-wikipedia-org-3485	220	17	insula	insula	NNP
en-wikipedia-org-3485	220	18	cortex	cortex	NNP
en-wikipedia-org-3485	220	19	may	may	MD
en-wikipedia-org-3485	220	20	each	each	DT
en-wikipedia-org-3485	220	21	contain	contain	VB
en-wikipedia-org-3485	220	22	their	-PRON-	PRP$
en-wikipedia-org-3485	220	23	own	own	JJ
en-wikipedia-org-3485	220	24	additional	additional	JJ
en-wikipedia-org-3485	220	25	hot	hot	JJ
en-wikipedia-org-3485	220	26	spots	spot	NNS
en-wikipedia-org-3485	220	27	(	(	-LRB-
en-wikipedia-org-3485	220	28	D.C.	D.C.	NNP
en-wikipedia-org-3485	220	29	Castro	Castro	NNP
en-wikipedia-org-3485	220	30	et	et	NNP
en-wikipedia-org-3485	220	31	al	al	NNP
en-wikipedia-org-3485	220	32	.	.	NNP
en-wikipedia-org-3485	220	33	,	,	,
en-wikipedia-org-3485	220	34	Soc	Soc	NNP
en-wikipedia-org-3485	220	35	.	.	.
en-wikipedia-org-3485	221	1	Neurosci	Neurosci	NNP
en-wikipedia-org-3485	221	2	.	.	.
en-wikipedia-org-3485	221	3	,	,	,
en-wikipedia-org-3485	221	4	abstract	abstract	JJ
en-wikipedia-org-3485	221	5	)	)	-RRB-
en-wikipedia-org-3485	221	6	.	.	.
en-wikipedia-org-3485	222	1	In	in	IN
en-wikipedia-org-3485	222	2	specific	specific	JJ
en-wikipedia-org-3485	222	3	subregions	subregion	NNS
en-wikipedia-org-3485	222	4	of	of	IN
en-wikipedia-org-3485	222	5	each	each	DT
en-wikipedia-org-3485	222	6	area	area	NN
en-wikipedia-org-3485	222	7	,	,	,
en-wikipedia-org-3485	222	8	either	either	CC
en-wikipedia-org-3485	222	9	opioid	opioid	NN
en-wikipedia-org-3485	222	10	-	-	HYPH
en-wikipedia-org-3485	222	11	stimulating	stimulating	NN
en-wikipedia-org-3485	222	12	or	or	CC
en-wikipedia-org-3485	222	13	orexin	orexin	RB
en-wikipedia-org-3485	222	14	-	-	HYPH
en-wikipedia-org-3485	222	15	stimulating	stimulate	VBG
en-wikipedia-org-3485	222	16	microinjections	microinjection	NNS
en-wikipedia-org-3485	222	17	appear	appear	VBP
en-wikipedia-org-3485	222	18	to	to	TO
en-wikipedia-org-3485	222	19	enhance	enhance	VB
en-wikipedia-org-3485	222	20	the	the	DT
en-wikipedia-org-3485	222	21	number	number	NN
en-wikipedia-org-3485	222	22	of	of	IN
en-wikipedia-org-3485	222	23	liking	like	VBG
en-wikipedia-org-3485	222	24	reactions	reaction	NNS
en-wikipedia-org-3485	222	25	elicited	elicit	VBN
en-wikipedia-org-3485	222	26	by	by	IN
en-wikipedia-org-3485	222	27	sweetness	sweetness	NN
en-wikipedia-org-3485	222	28	,	,	,
en-wikipedia-org-3485	222	29	similar	similar	JJ
en-wikipedia-org-3485	222	30	to	to	IN
en-wikipedia-org-3485	222	31	the	the	DT
en-wikipedia-org-3485	222	32	[	[	-LRB-
en-wikipedia-org-3485	222	33	nucleus	nucleus	NNP
en-wikipedia-org-3485	222	34	accumbens	accumbens	NNPS
en-wikipedia-org-3485	222	35	]	]	-RRB-
en-wikipedia-org-3485	222	36	NAc	NAc	NNS
en-wikipedia-org-3485	222	37	and	and	CC
en-wikipedia-org-3485	222	38	[	[	-LRB-
en-wikipedia-org-3485	222	39	ventral	ventral	JJ
en-wikipedia-org-3485	222	40	pallidum	pallidum	NN
en-wikipedia-org-3485	222	41	]	]	-RRB-
en-wikipedia-org-3485	222	42	VP	vp	FW
en-wikipedia-org-3485	222	43	hot	hot	JJ
en-wikipedia-org-3485	222	44	spots	spot	NNS
en-wikipedia-org-3485	222	45	.	.	.
en-wikipedia-org-3485	223	1	Successful	successful	JJ
en-wikipedia-org-3485	223	2	confirmation	confirmation	NN
en-wikipedia-org-3485	223	3	of	of	IN
en-wikipedia-org-3485	223	4	hedonic	hedonic	JJ
en-wikipedia-org-3485	223	5	hot	hot	JJ
en-wikipedia-org-3485	223	6	spots	spot	NNS
en-wikipedia-org-3485	223	7	in	in	IN
en-wikipedia-org-3485	223	8	the	the	DT
en-wikipedia-org-3485	223	9	OFC	OFC	NNP
en-wikipedia-org-3485	223	10	or	or	CC
en-wikipedia-org-3485	223	11	insula	insula	NN
en-wikipedia-org-3485	223	12	would	would	MD
en-wikipedia-org-3485	223	13	be	be	VB
en-wikipedia-org-3485	223	14	important	important	JJ
en-wikipedia-org-3485	223	15	and	and	CC
en-wikipedia-org-3485	223	16	possibly	possibly	RB
en-wikipedia-org-3485	223	17	relevant	relevant	JJ
en-wikipedia-org-3485	223	18	to	to	IN
en-wikipedia-org-3485	223	19	the	the	DT
en-wikipedia-org-3485	223	20	orbitofrontal	orbitofrontal	JJ
en-wikipedia-org-3485	223	21	mid	mid	NN
en-wikipedia-org-3485	223	22	-	-	NN
en-wikipedia-org-3485	223	23	anterior	anterior	JJ
en-wikipedia-org-3485	223	24	site	site	NN
en-wikipedia-org-3485	223	25	mentioned	mention	VBN
en-wikipedia-org-3485	223	26	earlier	early	RBR
en-wikipedia-org-3485	223	27	that	that	WDT
en-wikipedia-org-3485	223	28	especially	especially	RB
en-wikipedia-org-3485	223	29	tracks	track	VBZ
en-wikipedia-org-3485	223	30	the	the	DT
en-wikipedia-org-3485	223	31	subjective	subjective	JJ
en-wikipedia-org-3485	223	32	pleasure	pleasure	NN
en-wikipedia-org-3485	223	33	of	of	IN
en-wikipedia-org-3485	223	34	foods	food	NNS
en-wikipedia-org-3485	223	35	in	in	IN
en-wikipedia-org-3485	223	36	humans	human	NNS
en-wikipedia-org-3485	223	37	(	(	-LRB-
en-wikipedia-org-3485	223	38	Georgiadis	Georgiadis	NNP
en-wikipedia-org-3485	223	39	et	et	NNP
en-wikipedia-org-3485	223	40	al	al	NNP
en-wikipedia-org-3485	223	41	.	.	NNP
en-wikipedia-org-3485	223	42	,	,	,
en-wikipedia-org-3485	223	43	2012	2012	CD
en-wikipedia-org-3485	223	44	;	;	:
en-wikipedia-org-3485	223	45	Kringelbach	Kringelbach	NNP
en-wikipedia-org-3485	223	46	,	,	,
en-wikipedia-org-3485	223	47	2005	2005	CD
en-wikipedia-org-3485	223	48	;	;	:
en-wikipedia-org-3485	223	49	Kringelbach	Kringelbach	NNP
en-wikipedia-org-3485	223	50	et	et	NNP
en-wikipedia-org-3485	223	51	al	al	NNP
en-wikipedia-org-3485	223	52	.	.	NNP
en-wikipedia-org-3485	223	53	,	,	,
en-wikipedia-org-3485	223	54	2003	2003	CD
en-wikipedia-org-3485	223	55	;	;	:
en-wikipedia-org-3485	223	56	Small	Small	NNP
en-wikipedia-org-3485	223	57	et	et	NNP
en-wikipedia-org-3485	223	58	al	al	NNP
en-wikipedia-org-3485	223	59	.	.	NNP
en-wikipedia-org-3485	223	60	,	,	,
en-wikipedia-org-3485	223	61	2001	2001	CD
en-wikipedia-org-3485	223	62	;	;	:
en-wikipedia-org-3485	223	63	Veldhuizen	Veldhuizen	NNP
en-wikipedia-org-3485	223	64	et	et	NNP
en-wikipedia-org-3485	223	65	al	al	NNP
en-wikipedia-org-3485	223	66	.	.	NNP
en-wikipedia-org-3485	223	67	,	,	,
en-wikipedia-org-3485	223	68	2010	2010	CD
en-wikipedia-org-3485	223	69	)	)	-RRB-
en-wikipedia-org-3485	223	70	.	.	.
en-wikipedia-org-3485	224	1	Finally	finally	RB
en-wikipedia-org-3485	224	2	,	,	,
en-wikipedia-org-3485	224	3	in	in	IN
en-wikipedia-org-3485	224	4	the	the	DT
en-wikipedia-org-3485	224	5	brainstem	brainstem	NN
en-wikipedia-org-3485	224	6	,	,	,
en-wikipedia-org-3485	224	7	a	a	DT
en-wikipedia-org-3485	224	8	hindbrain	hindbrain	NN
en-wikipedia-org-3485	224	9	site	site	NN
en-wikipedia-org-3485	224	10	near	near	IN
en-wikipedia-org-3485	224	11	the	the	DT
en-wikipedia-org-3485	224	12	parabrachial	parabrachial	JJ
en-wikipedia-org-3485	224	13	nucleus	nucleus	NN
en-wikipedia-org-3485	224	14	of	of	IN
en-wikipedia-org-3485	224	15	dorsal	dorsal	NN
en-wikipedia-org-3485	224	16	pons	pon	NNS
en-wikipedia-org-3485	224	17	also	also	RB
en-wikipedia-org-3485	224	18	appears	appear	VBZ
en-wikipedia-org-3485	224	19	able	able	JJ
en-wikipedia-org-3485	224	20	to	to	TO
en-wikipedia-org-3485	224	21	contribute	contribute	VB
en-wikipedia-org-3485	224	22	to	to	IN
en-wikipedia-org-3485	224	23	hedonic	hedonic	JJ
en-wikipedia-org-3485	224	24	gains	gain	NNS
en-wikipedia-org-3485	224	25	of	of	IN
en-wikipedia-org-3485	224	26	function	function	NN
en-wikipedia-org-3485	224	27	(	(	-LRB-
en-wikipedia-org-3485	224	28	Söderpalm	Söderpalm	NNP
en-wikipedia-org-3485	224	29	and	and	CC
en-wikipedia-org-3485	224	30	Berridge	Berridge	NNP
en-wikipedia-org-3485	224	31	,	,	,
en-wikipedia-org-3485	224	32	2000	2000	CD
en-wikipedia-org-3485	224	33	)	)	-RRB-
en-wikipedia-org-3485	224	34	.	.	.
en-wikipedia-org-3485	225	1	A	a	DT
en-wikipedia-org-3485	225	2	brainstem	brainstem	NN
en-wikipedia-org-3485	225	3	mechanism	mechanism	NN
en-wikipedia-org-3485	225	4	for	for	IN
en-wikipedia-org-3485	225	5	pleasure	pleasure	NN
en-wikipedia-org-3485	225	6	may	may	MD
en-wikipedia-org-3485	225	7	seem	seem	VB
en-wikipedia-org-3485	225	8	more	more	RBR
en-wikipedia-org-3485	225	9	surprising	surprising	JJ
en-wikipedia-org-3485	225	10	than	than	IN
en-wikipedia-org-3485	225	11	forebrain	forebrain	JJ
en-wikipedia-org-3485	225	12	hot	hot	JJ
en-wikipedia-org-3485	225	13	spots	spot	NNS
en-wikipedia-org-3485	225	14	to	to	IN
en-wikipedia-org-3485	225	15	anyone	anyone	NN
en-wikipedia-org-3485	225	16	who	who	WP
en-wikipedia-org-3485	225	17	views	view	VBZ
en-wikipedia-org-3485	225	18	the	the	DT
en-wikipedia-org-3485	225	19	brainstem	brainstem	NN
en-wikipedia-org-3485	225	20	as	as	IN
en-wikipedia-org-3485	225	21	merely	merely	RB
en-wikipedia-org-3485	225	22	reflexive	reflexive	JJ
en-wikipedia-org-3485	225	23	,	,	,
en-wikipedia-org-3485	225	24	but	but	CC
en-wikipedia-org-3485	225	25	the	the	DT
en-wikipedia-org-3485	225	26	pontine	pontine	JJ
en-wikipedia-org-3485	225	27	parabrachial	parabrachial	JJ
en-wikipedia-org-3485	225	28	nucleus	nucleus	NN
en-wikipedia-org-3485	225	29	contributes	contribute	VBZ
en-wikipedia-org-3485	225	30	to	to	TO
en-wikipedia-org-3485	225	31	taste	taste	VB
en-wikipedia-org-3485	225	32	,	,	,
en-wikipedia-org-3485	225	33	pain	pain	NN
en-wikipedia-org-3485	225	34	,	,	,
en-wikipedia-org-3485	225	35	and	and	CC
en-wikipedia-org-3485	225	36	many	many	JJ
en-wikipedia-org-3485	225	37	visceral	visceral	JJ
en-wikipedia-org-3485	225	38	sensations	sensation	NNS
en-wikipedia-org-3485	225	39	from	from	IN
en-wikipedia-org-3485	225	40	the	the	DT
en-wikipedia-org-3485	225	41	body	body	NN
en-wikipedia-org-3485	225	42	and	and	CC
en-wikipedia-org-3485	225	43	has	have	VBZ
en-wikipedia-org-3485	225	44	also	also	RB
en-wikipedia-org-3485	225	45	been	be	VBN
en-wikipedia-org-3485	225	46	suggested	suggest	VBN
en-wikipedia-org-3485	225	47	to	to	TO
en-wikipedia-org-3485	225	48	play	play	VB
en-wikipedia-org-3485	225	49	an	an	DT
en-wikipedia-org-3485	225	50	important	important	JJ
en-wikipedia-org-3485	225	51	role	role	NN
en-wikipedia-org-3485	225	52	in	in	IN
en-wikipedia-org-3485	225	53	motivation	motivation	NN
en-wikipedia-org-3485	225	54	(	(	-LRB-
en-wikipedia-org-3485	225	55	Wu	Wu	NNP
en-wikipedia-org-3485	225	56	et	et	NNP
en-wikipedia-org-3485	225	57	al	al	NNP
en-wikipedia-org-3485	225	58	.	.	NNP
en-wikipedia-org-3485	225	59	,	,	,
en-wikipedia-org-3485	225	60	2012	2012	CD
en-wikipedia-org-3485	225	61	)	)	-RRB-
en-wikipedia-org-3485	225	62	and	and	CC
en-wikipedia-org-3485	225	63	in	in	IN
en-wikipedia-org-3485	225	64	human	human	JJ
en-wikipedia-org-3485	225	65	emotion	emotion	NN
en-wikipedia-org-3485	225	66	(	(	-LRB-
en-wikipedia-org-3485	225	67	especially	especially	RB
en-wikipedia-org-3485	225	68	related	related	JJ
en-wikipedia-org-3485	225	69	to	to	IN
en-wikipedia-org-3485	225	70	the	the	DT
en-wikipedia-org-3485	225	71	somatic	somatic	JJ
en-wikipedia-org-3485	225	72	marker	marker	NN
en-wikipedia-org-3485	225	73	hypothesis	hypothesis	NN
en-wikipedia-org-3485	225	74	)	)	-RRB-
en-wikipedia-org-3485	225	75	(	(	-LRB-
en-wikipedia-org-3485	225	76	Damasio	Damasio	NNP
en-wikipedia-org-3485	225	77	,	,	,
en-wikipedia-org-3485	225	78	2010	2010	CD
en-wikipedia-org-3485	225	79	)	)	-RRB-
en-wikipedia-org-3485	225	80	.	.	.
en-wikipedia-org-3485	226	1	^	^	NNP
en-wikipedia-org-3485	226	2	a	a	DT
en-wikipedia-org-3485	226	3	b	b	NNP
en-wikipedia-org-3485	226	4	c	c	NNP
en-wikipedia-org-3485	226	5	d	d	NNP
en-wikipedia-org-3485	226	6	e	e	NNP
en-wikipedia-org-3485	226	7	f	f	NNP
en-wikipedia-org-3485	226	8	g	g	NNP
en-wikipedia-org-3485	226	9	h	h	NNP
en-wikipedia-org-3485	226	10	i	i	NN
en-wikipedia-org-3485	226	11	Schultz	Schultz	NNP
en-wikipedia-org-3485	226	12	W	W	NNP
en-wikipedia-org-3485	226	13	(	(	-LRB-
en-wikipedia-org-3485	226	14	2015	2015	CD
en-wikipedia-org-3485	226	15	)	)	-RRB-
en-wikipedia-org-3485	226	16	.	.	.
en-wikipedia-org-3485	227	1	"	"	``
en-wikipedia-org-3485	227	2	Neuronal	neuronal	JJ
en-wikipedia-org-3485	227	3	reward	reward	NN
en-wikipedia-org-3485	227	4	and	and	CC
en-wikipedia-org-3485	227	5	decision	decision	NN
en-wikipedia-org-3485	227	6	signals	signal	NNS
en-wikipedia-org-3485	227	7	:	:	:
en-wikipedia-org-3485	227	8	from	from	IN
en-wikipedia-org-3485	227	9	theories	theory	NNS
en-wikipedia-org-3485	227	10	to	to	IN
en-wikipedia-org-3485	227	11	data	datum	NNS
en-wikipedia-org-3485	227	12	"	"	''
en-wikipedia-org-3485	227	13	.	.	.
en-wikipedia-org-3485	228	1	Physiological	Physiological	NNP
en-wikipedia-org-3485	228	2	Reviews	Reviews	NNPS
en-wikipedia-org-3485	228	3	.	.	.
en-wikipedia-org-3485	229	1	95	95	CD
en-wikipedia-org-3485	229	2	(	(	-LRB-
en-wikipedia-org-3485	229	3	3	3	CD
en-wikipedia-org-3485	229	4	)	)	-RRB-
en-wikipedia-org-3485	229	5	:	:	:
en-wikipedia-org-3485	229	6	853–951	853–951	CD
en-wikipedia-org-3485	229	7	.	.	.
en-wikipedia-org-3485	230	1	doi:10.1152	doi:10.1152	NNP
en-wikipedia-org-3485	230	2	/	/	SYM
en-wikipedia-org-3485	230	3	physrev.00023.2014	physrev.00023.2014	NNS
en-wikipedia-org-3485	230	4	.	.	.
en-wikipedia-org-3485	231	1	PMC	PMC	NNP
en-wikipedia-org-3485	231	2	 	  	_SP
en-wikipedia-org-3485	231	3	4491543	4491543	CD
en-wikipedia-org-3485	231	4	.	.	.
en-wikipedia-org-3485	232	1	PMID	PMID	NNP
en-wikipedia-org-3485	232	2	 	  	_SP
en-wikipedia-org-3485	232	3	26109341	26109341	CD
en-wikipedia-org-3485	232	4	.	.	.
en-wikipedia-org-3485	233	1	Rewards	reward	NNS
en-wikipedia-org-3485	233	2	in	in	IN
en-wikipedia-org-3485	233	3	operant	operant	JJ
en-wikipedia-org-3485	233	4	conditioning	conditioning	NN
en-wikipedia-org-3485	233	5	are	be	VBP
en-wikipedia-org-3485	233	6	positive	positive	JJ
en-wikipedia-org-3485	233	7	reinforcers	reinforcer	NNS
en-wikipedia-org-3485	233	8	.	.	.
en-wikipedia-org-3485	234	1	...	...	:
en-wikipedia-org-3485	234	2	Operant	operant	JJ
en-wikipedia-org-3485	234	3	behavior	behavior	NN
en-wikipedia-org-3485	234	4	gives	give	VBZ
en-wikipedia-org-3485	234	5	a	a	DT
en-wikipedia-org-3485	234	6	good	good	JJ
en-wikipedia-org-3485	234	7	definition	definition	NN
en-wikipedia-org-3485	234	8	for	for	IN
en-wikipedia-org-3485	234	9	rewards	reward	NNS
en-wikipedia-org-3485	234	10	.	.	.
en-wikipedia-org-3485	235	1	Anything	anything	NN
en-wikipedia-org-3485	235	2	that	that	WDT
en-wikipedia-org-3485	235	3	makes	make	VBZ
en-wikipedia-org-3485	235	4	an	an	DT
en-wikipedia-org-3485	235	5	individual	individual	NN
en-wikipedia-org-3485	235	6	come	come	VBN
en-wikipedia-org-3485	235	7	back	back	RB
en-wikipedia-org-3485	235	8	for	for	IN
en-wikipedia-org-3485	235	9	more	more	RBR
en-wikipedia-org-3485	235	10	is	be	VBZ
en-wikipedia-org-3485	235	11	a	a	DT
en-wikipedia-org-3485	235	12	positive	positive	JJ
en-wikipedia-org-3485	235	13	reinforcer	reinforcer	NN
en-wikipedia-org-3485	235	14	and	and	CC
en-wikipedia-org-3485	235	15	therefore	therefore	RB
en-wikipedia-org-3485	235	16	a	a	DT
en-wikipedia-org-3485	235	17	reward	reward	NN
en-wikipedia-org-3485	235	18	.	.	.
en-wikipedia-org-3485	236	1	Although	although	IN
en-wikipedia-org-3485	236	2	it	-PRON-	PRP
en-wikipedia-org-3485	236	3	provides	provide	VBZ
en-wikipedia-org-3485	236	4	a	a	DT
en-wikipedia-org-3485	236	5	good	good	JJ
en-wikipedia-org-3485	236	6	definition	definition	NN
en-wikipedia-org-3485	236	7	,	,	,
en-wikipedia-org-3485	236	8	positive	positive	JJ
en-wikipedia-org-3485	236	9	reinforcement	reinforcement	NN
en-wikipedia-org-3485	236	10	is	be	VBZ
en-wikipedia-org-3485	236	11	only	only	RB
en-wikipedia-org-3485	236	12	one	one	CD
en-wikipedia-org-3485	236	13	of	of	IN
en-wikipedia-org-3485	236	14	several	several	JJ
en-wikipedia-org-3485	236	15	reward	reward	NN
en-wikipedia-org-3485	236	16	functions	function	NNS
en-wikipedia-org-3485	236	17	.	.	.
en-wikipedia-org-3485	237	1	...	...	NFP
en-wikipedia-org-3485	238	1	Rewards	reward	NNS
en-wikipedia-org-3485	238	2	are	be	VBP
en-wikipedia-org-3485	238	3	attractive	attractive	JJ
en-wikipedia-org-3485	238	4	.	.	.
en-wikipedia-org-3485	239	1	They	-PRON-	PRP
en-wikipedia-org-3485	239	2	are	be	VBP
en-wikipedia-org-3485	239	3	motivating	motivate	VBG
en-wikipedia-org-3485	239	4	and	and	CC
en-wikipedia-org-3485	239	5	make	make	VB
en-wikipedia-org-3485	239	6	us	-PRON-	PRP
en-wikipedia-org-3485	239	7	exert	exert	VB
en-wikipedia-org-3485	239	8	an	an	DT
en-wikipedia-org-3485	239	9	effort	effort	NN
en-wikipedia-org-3485	239	10	.	.	.
en-wikipedia-org-3485	240	1	...	...	NFP
en-wikipedia-org-3485	241	1	Rewards	reward	NNS
en-wikipedia-org-3485	241	2	induce	induce	VBP
en-wikipedia-org-3485	241	3	approach	approach	NN
en-wikipedia-org-3485	241	4	behavior	behavior	NN
en-wikipedia-org-3485	241	5	,	,	,
en-wikipedia-org-3485	241	6	also	also	RB
en-wikipedia-org-3485	241	7	called	call	VBD
en-wikipedia-org-3485	241	8	appetitive	appetitive	JJ
en-wikipedia-org-3485	241	9	or	or	CC
en-wikipedia-org-3485	241	10	preparatory	preparatory	JJ
en-wikipedia-org-3485	241	11	behavior	behavior	NN
en-wikipedia-org-3485	241	12	,	,	,
en-wikipedia-org-3485	241	13	sexual	sexual	JJ
en-wikipedia-org-3485	241	14	behavior	behavior	NN
en-wikipedia-org-3485	241	15	,	,	,
en-wikipedia-org-3485	241	16	and	and	CC
en-wikipedia-org-3485	241	17	consummatory	consummatory	JJ
en-wikipedia-org-3485	241	18	behavior	behavior	NN
en-wikipedia-org-3485	241	19	.	.	.
en-wikipedia-org-3485	242	1	...	...	NFP
en-wikipedia-org-3485	243	1	Thus	thus	RB
en-wikipedia-org-3485	243	2	any	any	DT
en-wikipedia-org-3485	243	3	stimulus	stimulus	NN
en-wikipedia-org-3485	243	4	,	,	,
en-wikipedia-org-3485	243	5	object	object	NN
en-wikipedia-org-3485	243	6	,	,	,
en-wikipedia-org-3485	243	7	event	event	NN
en-wikipedia-org-3485	243	8	,	,	,
en-wikipedia-org-3485	243	9	activity	activity	NN
en-wikipedia-org-3485	243	10	,	,	,
en-wikipedia-org-3485	243	11	or	or	CC
en-wikipedia-org-3485	243	12	situation	situation	NN
en-wikipedia-org-3485	243	13	that	that	WDT
en-wikipedia-org-3485	243	14	has	have	VBZ
en-wikipedia-org-3485	243	15	the	the	DT
en-wikipedia-org-3485	243	16	potential	potential	NN
en-wikipedia-org-3485	243	17	to	to	TO
en-wikipedia-org-3485	243	18	make	make	VB
en-wikipedia-org-3485	243	19	us	-PRON-	PRP
en-wikipedia-org-3485	243	20	approach	approach	VB
en-wikipedia-org-3485	243	21	and	and	CC
en-wikipedia-org-3485	243	22	consume	consume	VB
en-wikipedia-org-3485	243	23	it	-PRON-	PRP
en-wikipedia-org-3485	243	24	is	be	VBZ
en-wikipedia-org-3485	243	25	by	by	IN
en-wikipedia-org-3485	243	26	definition	definition	NN
en-wikipedia-org-3485	243	27	a	a	DT
en-wikipedia-org-3485	243	28	reward	reward	NN
en-wikipedia-org-3485	243	29	.	.	.
en-wikipedia-org-3485	244	1	...	...	:
en-wikipedia-org-3485	244	2	Rewarding	rewarding	JJ
en-wikipedia-org-3485	244	3	stimuli	stimulus	NNS
en-wikipedia-org-3485	244	4	,	,	,
en-wikipedia-org-3485	244	5	objects	object	NNS
en-wikipedia-org-3485	244	6	,	,	,
en-wikipedia-org-3485	244	7	events	event	NNS
en-wikipedia-org-3485	244	8	,	,	,
en-wikipedia-org-3485	244	9	situations	situation	NNS
en-wikipedia-org-3485	244	10	,	,	,
en-wikipedia-org-3485	244	11	and	and	CC
en-wikipedia-org-3485	244	12	activities	activity	NNS
en-wikipedia-org-3485	244	13	consist	consist	VBP
en-wikipedia-org-3485	244	14	of	of	IN
en-wikipedia-org-3485	244	15	several	several	JJ
en-wikipedia-org-3485	244	16	major	major	JJ
en-wikipedia-org-3485	244	17	components	component	NNS
en-wikipedia-org-3485	244	18	.	.	.
en-wikipedia-org-3485	245	1	First	first	RB
en-wikipedia-org-3485	245	2	,	,	,
en-wikipedia-org-3485	245	3	rewards	reward	NNS
en-wikipedia-org-3485	245	4	have	have	VBP
en-wikipedia-org-3485	245	5	basic	basic	JJ
en-wikipedia-org-3485	245	6	sensory	sensory	JJ
en-wikipedia-org-3485	245	7	components	component	NNS
en-wikipedia-org-3485	245	8	(	(	-LRB-
en-wikipedia-org-3485	245	9	visual	visual	JJ
en-wikipedia-org-3485	245	10	,	,	,
en-wikipedia-org-3485	245	11	auditory	auditory	JJ
en-wikipedia-org-3485	245	12	,	,	,
en-wikipedia-org-3485	245	13	somatosensory	somatosensory	NN
en-wikipedia-org-3485	245	14	,	,	,
en-wikipedia-org-3485	245	15	gustatory	gustatory	NN
en-wikipedia-org-3485	245	16	,	,	,
en-wikipedia-org-3485	245	17	and	and	CC
en-wikipedia-org-3485	245	18	olfactory	olfactory	NN
en-wikipedia-org-3485	245	19	)	)	-RRB-
en-wikipedia-org-3485	245	20	 	  	_SP
en-wikipedia-org-3485	245	21	...	...	.
en-wikipedia-org-3485	245	22	Second	second	RB
en-wikipedia-org-3485	245	23	,	,	,
en-wikipedia-org-3485	245	24	rewards	reward	NNS
en-wikipedia-org-3485	245	25	are	be	VBP
en-wikipedia-org-3485	245	26	salient	salient	NN
en-wikipedia-org-3485	245	27	and	and	CC
en-wikipedia-org-3485	245	28	thus	thus	RB
en-wikipedia-org-3485	245	29	elicit	elicit	JJ
en-wikipedia-org-3485	245	30	attention	attention	NN
en-wikipedia-org-3485	245	31	,	,	,
en-wikipedia-org-3485	245	32	which	which	WDT
en-wikipedia-org-3485	245	33	are	be	VBP
en-wikipedia-org-3485	245	34	manifested	manifest	VBN
en-wikipedia-org-3485	245	35	as	as	IN
en-wikipedia-org-3485	245	36	orienting	orient	VBG
en-wikipedia-org-3485	245	37	responses	response	NNS
en-wikipedia-org-3485	245	38	(	(	-LRB-
en-wikipedia-org-3485	245	39	FIGURE	FIGURE	NNP
en-wikipedia-org-3485	245	40	1	1	CD
en-wikipedia-org-3485	245	41	,	,	,
en-wikipedia-org-3485	245	42	middle	middle	JJ
en-wikipedia-org-3485	245	43	)	)	-RRB-
en-wikipedia-org-3485	245	44	.	.	.
en-wikipedia-org-3485	246	1	The	the	DT
en-wikipedia-org-3485	246	2	salience	salience	NN
en-wikipedia-org-3485	246	3	of	of	IN
en-wikipedia-org-3485	246	4	rewards	reward	NNS
en-wikipedia-org-3485	246	5	derives	derive	VBZ
en-wikipedia-org-3485	246	6	from	from	IN
en-wikipedia-org-3485	246	7	three	three	CD
en-wikipedia-org-3485	246	8	principal	principal	JJ
en-wikipedia-org-3485	246	9	factors	factor	NNS
en-wikipedia-org-3485	246	10	,	,	,
en-wikipedia-org-3485	246	11	namely	namely	RB
en-wikipedia-org-3485	246	12	,	,	,
en-wikipedia-org-3485	246	13	their	-PRON-	PRP$
en-wikipedia-org-3485	246	14	physical	physical	JJ
en-wikipedia-org-3485	246	15	intensity	intensity	NN
en-wikipedia-org-3485	246	16	and	and	CC
en-wikipedia-org-3485	246	17	impact	impact	NN
en-wikipedia-org-3485	246	18	(	(	-LRB-
en-wikipedia-org-3485	246	19	physical	physical	JJ
en-wikipedia-org-3485	246	20	salience	salience	NN
en-wikipedia-org-3485	246	21	)	)	-RRB-
en-wikipedia-org-3485	246	22	,	,	,
en-wikipedia-org-3485	246	23	their	-PRON-	PRP$
en-wikipedia-org-3485	246	24	novelty	novelty	NN
en-wikipedia-org-3485	246	25	and	and	CC
en-wikipedia-org-3485	246	26	surprise	surprise	NN
en-wikipedia-org-3485	246	27	(	(	-LRB-
en-wikipedia-org-3485	246	28	novelty	novelty	NN
en-wikipedia-org-3485	246	29	/	/	SYM
en-wikipedia-org-3485	246	30	surprise	surprise	NN
en-wikipedia-org-3485	246	31	salience	salience	NN
en-wikipedia-org-3485	246	32	)	)	-RRB-
en-wikipedia-org-3485	246	33	,	,	,
en-wikipedia-org-3485	246	34	and	and	CC
en-wikipedia-org-3485	246	35	their	-PRON-	PRP$
en-wikipedia-org-3485	246	36	general	general	JJ
en-wikipedia-org-3485	246	37	motivational	motivational	JJ
en-wikipedia-org-3485	246	38	impact	impact	NN
en-wikipedia-org-3485	246	39	shared	share	VBN
en-wikipedia-org-3485	246	40	with	with	IN
en-wikipedia-org-3485	246	41	punishers	punisher	NNS
en-wikipedia-org-3485	246	42	(	(	-LRB-
en-wikipedia-org-3485	246	43	motivational	motivational	JJ
en-wikipedia-org-3485	246	44	salience	salience	NN
en-wikipedia-org-3485	246	45	)	)	-RRB-
en-wikipedia-org-3485	246	46	.	.	.
en-wikipedia-org-3485	247	1	A	a	DT
en-wikipedia-org-3485	247	2	separate	separate	JJ
en-wikipedia-org-3485	247	3	form	form	NN
en-wikipedia-org-3485	247	4	not	not	RB
en-wikipedia-org-3485	247	5	included	include	VBN
en-wikipedia-org-3485	247	6	in	in	IN
en-wikipedia-org-3485	247	7	this	this	DT
en-wikipedia-org-3485	247	8	scheme	scheme	NN
en-wikipedia-org-3485	247	9	,	,	,
en-wikipedia-org-3485	247	10	incentive	incentive	NN
en-wikipedia-org-3485	247	11	salience	salience	NN
en-wikipedia-org-3485	247	12	,	,	,
en-wikipedia-org-3485	247	13	primarily	primarily	RB
en-wikipedia-org-3485	247	14	addresses	address	VBZ
en-wikipedia-org-3485	247	15	dopamine	dopamine	NN
en-wikipedia-org-3485	247	16	function	function	NN
en-wikipedia-org-3485	247	17	in	in	IN
en-wikipedia-org-3485	247	18	addiction	addiction	NN
en-wikipedia-org-3485	247	19	and	and	CC
en-wikipedia-org-3485	247	20	refers	refer	VBZ
en-wikipedia-org-3485	247	21	only	only	RB
en-wikipedia-org-3485	247	22	to	to	TO
en-wikipedia-org-3485	247	23	approach	approach	VB
en-wikipedia-org-3485	247	24	behavior	behavior	NN
en-wikipedia-org-3485	247	25	(	(	-LRB-
en-wikipedia-org-3485	247	26	as	as	IN
en-wikipedia-org-3485	247	27	opposed	oppose	VBN
en-wikipedia-org-3485	247	28	to	to	IN
en-wikipedia-org-3485	247	29	learning	learning	NN
en-wikipedia-org-3485	247	30	)	)	-RRB-
en-wikipedia-org-3485	247	31	 	  	_SP
en-wikipedia-org-3485	247	32	...	...	.
en-wikipedia-org-3485	247	33	Third	third	RB
en-wikipedia-org-3485	247	34	,	,	,
en-wikipedia-org-3485	247	35	rewards	reward	NNS
en-wikipedia-org-3485	247	36	have	have	VBP
en-wikipedia-org-3485	247	37	a	a	DT
en-wikipedia-org-3485	247	38	value	value	NN
en-wikipedia-org-3485	247	39	component	component	NN
en-wikipedia-org-3485	247	40	that	that	WDT
en-wikipedia-org-3485	247	41	determines	determine	VBZ
en-wikipedia-org-3485	247	42	the	the	DT
en-wikipedia-org-3485	247	43	positively	positively	RB
en-wikipedia-org-3485	247	44	motivating	motivating	JJ
en-wikipedia-org-3485	247	45	effects	effect	NNS
en-wikipedia-org-3485	247	46	of	of	IN
en-wikipedia-org-3485	247	47	rewards	reward	NNS
en-wikipedia-org-3485	247	48	and	and	CC
en-wikipedia-org-3485	247	49	is	be	VBZ
en-wikipedia-org-3485	247	50	not	not	RB
en-wikipedia-org-3485	247	51	contained	contain	VBN
en-wikipedia-org-3485	247	52	in	in	IN
en-wikipedia-org-3485	247	53	,	,	,
en-wikipedia-org-3485	247	54	nor	nor	CC
en-wikipedia-org-3485	247	55	explained	explain	VBN
en-wikipedia-org-3485	247	56	by	by	IN
en-wikipedia-org-3485	247	57	,	,	,
en-wikipedia-org-3485	247	58	the	the	DT
en-wikipedia-org-3485	247	59	sensory	sensory	JJ
en-wikipedia-org-3485	247	60	and	and	CC
en-wikipedia-org-3485	247	61	attentional	attentional	JJ
en-wikipedia-org-3485	247	62	components	component	NNS
en-wikipedia-org-3485	247	63	(	(	-LRB-
en-wikipedia-org-3485	247	64	FIGURE	FIGURE	NNP
en-wikipedia-org-3485	247	65	1	1	CD
en-wikipedia-org-3485	247	66	,	,	,
en-wikipedia-org-3485	247	67	right	right	RB
en-wikipedia-org-3485	247	68	)	)	-RRB-
en-wikipedia-org-3485	247	69	.	.	.
en-wikipedia-org-3485	248	1	This	this	DT
en-wikipedia-org-3485	248	2	component	component	NN
en-wikipedia-org-3485	248	3	reflects	reflect	VBZ
en-wikipedia-org-3485	248	4	behavioral	behavioral	JJ
en-wikipedia-org-3485	248	5	preferences	preference	NNS
en-wikipedia-org-3485	248	6	and	and	CC
en-wikipedia-org-3485	248	7	thus	thus	RB
en-wikipedia-org-3485	248	8	is	be	VBZ
en-wikipedia-org-3485	248	9	subjective	subjective	JJ
en-wikipedia-org-3485	248	10	and	and	CC
en-wikipedia-org-3485	248	11	only	only	RB
en-wikipedia-org-3485	248	12	partially	partially	RB
en-wikipedia-org-3485	248	13	determined	determine	VBN
en-wikipedia-org-3485	248	14	by	by	IN
en-wikipedia-org-3485	248	15	physical	physical	JJ
en-wikipedia-org-3485	248	16	parameters	parameter	NNS
en-wikipedia-org-3485	248	17	.	.	.
en-wikipedia-org-3485	249	1	Only	only	RB
en-wikipedia-org-3485	249	2	this	this	DT
en-wikipedia-org-3485	249	3	component	component	NN
en-wikipedia-org-3485	249	4	constitutes	constitute	VBZ
en-wikipedia-org-3485	249	5	what	what	WP
en-wikipedia-org-3485	249	6	we	-PRON-	PRP
en-wikipedia-org-3485	249	7	understand	understand	VBP
en-wikipedia-org-3485	249	8	as	as	IN
en-wikipedia-org-3485	249	9	a	a	DT
en-wikipedia-org-3485	249	10	reward	reward	NN
en-wikipedia-org-3485	249	11	.	.	.
en-wikipedia-org-3485	250	1	It	-PRON-	PRP
en-wikipedia-org-3485	250	2	mediates	mediate	VBZ
en-wikipedia-org-3485	250	3	the	the	DT
en-wikipedia-org-3485	250	4	specific	specific	JJ
en-wikipedia-org-3485	250	5	behavioral	behavioral	JJ
en-wikipedia-org-3485	250	6	reinforcing	reinforcing	NN
en-wikipedia-org-3485	250	7	,	,	,
en-wikipedia-org-3485	250	8	approach	approach	NN
en-wikipedia-org-3485	250	9	generating	generating	NN
en-wikipedia-org-3485	250	10	,	,	,
en-wikipedia-org-3485	250	11	and	and	CC
en-wikipedia-org-3485	250	12	emotional	emotional	JJ
en-wikipedia-org-3485	250	13	effects	effect	NNS
en-wikipedia-org-3485	250	14	of	of	IN
en-wikipedia-org-3485	250	15	rewards	reward	NNS
en-wikipedia-org-3485	250	16	that	that	WDT
en-wikipedia-org-3485	250	17	are	be	VBP
en-wikipedia-org-3485	250	18	crucial	crucial	JJ
en-wikipedia-org-3485	250	19	for	for	IN
en-wikipedia-org-3485	250	20	the	the	DT
en-wikipedia-org-3485	250	21	organism	organism	NN
en-wikipedia-org-3485	250	22	’s	’s	POS
en-wikipedia-org-3485	250	23	survival	survival	NN
en-wikipedia-org-3485	250	24	and	and	CC
en-wikipedia-org-3485	250	25	reproduction	reproduction	NN
en-wikipedia-org-3485	250	26	,	,	,
en-wikipedia-org-3485	250	27	whereas	whereas	IN
en-wikipedia-org-3485	250	28	all	all	DT
en-wikipedia-org-3485	250	29	other	other	JJ
en-wikipedia-org-3485	250	30	components	component	NNS
en-wikipedia-org-3485	250	31	are	be	VBP
en-wikipedia-org-3485	250	32	only	only	RB
en-wikipedia-org-3485	250	33	supportive	supportive	JJ
en-wikipedia-org-3485	250	34	of	of	IN
en-wikipedia-org-3485	250	35	these	these	DT
en-wikipedia-org-3485	250	36	functions	function	NNS
en-wikipedia-org-3485	250	37	.	.	.
en-wikipedia-org-3485	251	1	...	...	NFP
en-wikipedia-org-3485	252	1	Rewards	reward	NNS
en-wikipedia-org-3485	252	2	can	can	MD
en-wikipedia-org-3485	252	3	also	also	RB
en-wikipedia-org-3485	252	4	be	be	VB
en-wikipedia-org-3485	252	5	intrinsic	intrinsic	JJ
en-wikipedia-org-3485	252	6	to	to	IN
en-wikipedia-org-3485	252	7	behavior	behavior	NN
en-wikipedia-org-3485	252	8	(	(	-LRB-
en-wikipedia-org-3485	252	9	31	31	CD
en-wikipedia-org-3485	252	10	,	,	,
en-wikipedia-org-3485	252	11	546	546	CD
en-wikipedia-org-3485	252	12	,	,	,
en-wikipedia-org-3485	252	13	547	547	CD
en-wikipedia-org-3485	252	14	)	)	-RRB-
en-wikipedia-org-3485	252	15	.	.	.
en-wikipedia-org-3485	253	1	They	-PRON-	PRP
en-wikipedia-org-3485	253	2	contrast	contrast	VBP
en-wikipedia-org-3485	253	3	with	with	IN
en-wikipedia-org-3485	253	4	extrinsic	extrinsic	JJ
en-wikipedia-org-3485	253	5	rewards	reward	NNS
en-wikipedia-org-3485	253	6	that	that	WDT
en-wikipedia-org-3485	253	7	provide	provide	VBP
en-wikipedia-org-3485	253	8	motivation	motivation	NN
en-wikipedia-org-3485	253	9	for	for	IN
en-wikipedia-org-3485	253	10	behavior	behavior	NN
en-wikipedia-org-3485	253	11	and	and	CC
en-wikipedia-org-3485	253	12	constitute	constitute	VB
en-wikipedia-org-3485	253	13	the	the	DT
en-wikipedia-org-3485	253	14	essence	essence	NN
en-wikipedia-org-3485	253	15	of	of	IN
en-wikipedia-org-3485	253	16	operant	operant	JJ
en-wikipedia-org-3485	253	17	behavior	behavior	NN
en-wikipedia-org-3485	253	18	in	in	IN
en-wikipedia-org-3485	253	19	laboratory	laboratory	NN
en-wikipedia-org-3485	253	20	tests	test	NNS
en-wikipedia-org-3485	253	21	.	.	.
en-wikipedia-org-3485	254	1	Intrinsic	intrinsic	JJ
en-wikipedia-org-3485	254	2	rewards	reward	NNS
en-wikipedia-org-3485	254	3	are	be	VBP
en-wikipedia-org-3485	254	4	activities	activity	NNS
en-wikipedia-org-3485	254	5	that	that	WDT
en-wikipedia-org-3485	254	6	are	be	VBP
en-wikipedia-org-3485	254	7	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	254	8	on	on	IN
en-wikipedia-org-3485	254	9	their	-PRON-	PRP$
en-wikipedia-org-3485	254	10	own	own	JJ
en-wikipedia-org-3485	254	11	and	and	CC
en-wikipedia-org-3485	254	12	are	be	VBP
en-wikipedia-org-3485	254	13	undertaken	undertake	VBN
en-wikipedia-org-3485	254	14	for	for	IN
en-wikipedia-org-3485	254	15	their	-PRON-	PRP$
en-wikipedia-org-3485	254	16	own	own	JJ
en-wikipedia-org-3485	254	17	sake	sake	NN
en-wikipedia-org-3485	254	18	,	,	,
en-wikipedia-org-3485	254	19	without	without	IN
en-wikipedia-org-3485	254	20	being	be	VBG
en-wikipedia-org-3485	254	21	the	the	DT
en-wikipedia-org-3485	254	22	means	mean	NNS
en-wikipedia-org-3485	254	23	for	for	IN
en-wikipedia-org-3485	254	24	getting	get	VBG
en-wikipedia-org-3485	254	25	extrinsic	extrinsic	JJ
en-wikipedia-org-3485	254	26	rewards	reward	NNS
en-wikipedia-org-3485	254	27	.	.	.
en-wikipedia-org-3485	255	1	...	...	:
en-wikipedia-org-3485	255	2	Intrinsic	intrinsic	JJ
en-wikipedia-org-3485	255	3	rewards	reward	NNS
en-wikipedia-org-3485	255	4	are	be	VBP
en-wikipedia-org-3485	255	5	genuine	genuine	JJ
en-wikipedia-org-3485	255	6	rewards	reward	NNS
en-wikipedia-org-3485	255	7	in	in	IN
en-wikipedia-org-3485	255	8	their	-PRON-	PRP$
en-wikipedia-org-3485	255	9	own	own	JJ
en-wikipedia-org-3485	255	10	right	right	NN
en-wikipedia-org-3485	255	11	,	,	,
en-wikipedia-org-3485	255	12	as	as	IN
en-wikipedia-org-3485	255	13	they	-PRON-	PRP
en-wikipedia-org-3485	255	14	induce	induce	VBP
en-wikipedia-org-3485	255	15	learning	learn	VBG
en-wikipedia-org-3485	255	16	,	,	,
en-wikipedia-org-3485	255	17	approach	approach	NN
en-wikipedia-org-3485	255	18	,	,	,
en-wikipedia-org-3485	255	19	and	and	CC
en-wikipedia-org-3485	255	20	pleasure	pleasure	NN
en-wikipedia-org-3485	255	21	,	,	,
en-wikipedia-org-3485	255	22	like	like	IN
en-wikipedia-org-3485	255	23	perfectioning	perfectione	VBG
en-wikipedia-org-3485	255	24	,	,	,
en-wikipedia-org-3485	255	25	playing	playing	NN
en-wikipedia-org-3485	255	26	,	,	,
en-wikipedia-org-3485	255	27	and	and	CC
en-wikipedia-org-3485	255	28	enjoying	enjoy	VBG
en-wikipedia-org-3485	255	29	the	the	DT
en-wikipedia-org-3485	255	30	piano	piano	NN
en-wikipedia-org-3485	255	31	.	.	.
en-wikipedia-org-3485	256	1	Although	although	IN
en-wikipedia-org-3485	256	2	they	-PRON-	PRP
en-wikipedia-org-3485	256	3	can	can	MD
en-wikipedia-org-3485	256	4	serve	serve	VB
en-wikipedia-org-3485	256	5	to	to	IN
en-wikipedia-org-3485	256	6	condition	condition	NN
en-wikipedia-org-3485	256	7	higher	high	JJR
en-wikipedia-org-3485	256	8	order	order	NN
en-wikipedia-org-3485	256	9	rewards	reward	NNS
en-wikipedia-org-3485	256	10	,	,	,
en-wikipedia-org-3485	256	11	they	-PRON-	PRP
en-wikipedia-org-3485	256	12	are	be	VBP
en-wikipedia-org-3485	256	13	not	not	RB
en-wikipedia-org-3485	256	14	conditioned	condition	VBN
en-wikipedia-org-3485	256	15	,	,	,
en-wikipedia-org-3485	256	16	higher	high	JJR
en-wikipedia-org-3485	256	17	order	order	NN
en-wikipedia-org-3485	256	18	rewards	reward	NNS
en-wikipedia-org-3485	256	19	,	,	,
en-wikipedia-org-3485	256	20	as	as	IN
en-wikipedia-org-3485	256	21	attaining	attain	VBG
en-wikipedia-org-3485	256	22	their	-PRON-	PRP$
en-wikipedia-org-3485	256	23	reward	reward	NN
en-wikipedia-org-3485	256	24	properties	property	NNS
en-wikipedia-org-3485	256	25	does	do	VBZ
en-wikipedia-org-3485	256	26	not	not	RB
en-wikipedia-org-3485	256	27	require	require	VB
en-wikipedia-org-3485	256	28	pairing	pair	VBG
en-wikipedia-org-3485	256	29	with	with	IN
en-wikipedia-org-3485	256	30	an	an	DT
en-wikipedia-org-3485	256	31	unconditioned	unconditioned	JJ
en-wikipedia-org-3485	256	32	reward	reward	NN
en-wikipedia-org-3485	256	33	.	.	.
en-wikipedia-org-3485	257	1	...	...	NFP
en-wikipedia-org-3485	258	1	These	these	DT
en-wikipedia-org-3485	258	2	emotions	emotion	NNS
en-wikipedia-org-3485	258	3	are	be	VBP
en-wikipedia-org-3485	258	4	also	also	RB
en-wikipedia-org-3485	258	5	called	call	VBN
en-wikipedia-org-3485	258	6	liking	like	VBG
en-wikipedia-org-3485	258	7	(	(	-LRB-
en-wikipedia-org-3485	258	8	for	for	IN
en-wikipedia-org-3485	258	9	pleasure	pleasure	NN
en-wikipedia-org-3485	258	10	)	)	-RRB-
en-wikipedia-org-3485	258	11	and	and	CC
en-wikipedia-org-3485	258	12	wanting	want	VBG
en-wikipedia-org-3485	258	13	(	(	-LRB-
en-wikipedia-org-3485	258	14	for	for	IN
en-wikipedia-org-3485	258	15	desire	desire	NN
en-wikipedia-org-3485	258	16	)	)	-RRB-
en-wikipedia-org-3485	258	17	in	in	IN
en-wikipedia-org-3485	258	18	addiction	addiction	NN
en-wikipedia-org-3485	258	19	research	research	NN
en-wikipedia-org-3485	258	20	(	(	-LRB-
en-wikipedia-org-3485	258	21	471	471	CD
en-wikipedia-org-3485	258	22	)	)	-RRB-
en-wikipedia-org-3485	258	23	and	and	CC
en-wikipedia-org-3485	258	24	strongly	strongly	RB
en-wikipedia-org-3485	258	25	support	support	VB
en-wikipedia-org-3485	258	26	the	the	DT
en-wikipedia-org-3485	258	27	learning	learning	NN
en-wikipedia-org-3485	258	28	and	and	CC
en-wikipedia-org-3485	258	29	approach	approach	NN
en-wikipedia-org-3485	258	30	generating	generating	NN
en-wikipedia-org-3485	258	31	functions	function	NNS
en-wikipedia-org-3485	258	32	of	of	IN
en-wikipedia-org-3485	258	33	reward	reward	NN
en-wikipedia-org-3485	258	34	.	.	.
en-wikipedia-org-3485	259	1	^	^	NNP
en-wikipedia-org-3485	259	2	Malenka	Malenka	NNP
en-wikipedia-org-3485	259	3	RC	RC	NNP
en-wikipedia-org-3485	259	4	,	,	,
en-wikipedia-org-3485	259	5	Nestler	Nestler	NNP
en-wikipedia-org-3485	259	6	EJ	EJ	NNP
en-wikipedia-org-3485	259	7	,	,	,
en-wikipedia-org-3485	259	8	Hyman	Hyman	NNP
en-wikipedia-org-3485	259	9	SE	SE	NNP
en-wikipedia-org-3485	259	10	(	(	-LRB-
en-wikipedia-org-3485	259	11	2009	2009	CD
en-wikipedia-org-3485	259	12	)	)	-RRB-
en-wikipedia-org-3485	259	13	.	.	.
en-wikipedia-org-3485	260	1	"	"	``
en-wikipedia-org-3485	260	2	Chapter	chapter	NN
en-wikipedia-org-3485	260	3	15	15	CD
en-wikipedia-org-3485	260	4	:	:	:
en-wikipedia-org-3485	260	5	Reinforcement	reinforcement	NN
en-wikipedia-org-3485	260	6	and	and	CC
en-wikipedia-org-3485	260	7	Addictive	Addictive	NNP
en-wikipedia-org-3485	260	8	Disorders	Disorders	NNPS
en-wikipedia-org-3485	260	9	"	"	''
en-wikipedia-org-3485	260	10	.	.	.
en-wikipedia-org-3485	261	1	In	in	IN
en-wikipedia-org-3485	261	2	Sydor	Sydor	NNP
en-wikipedia-org-3485	261	3	A	A	NNP
en-wikipedia-org-3485	261	4	,	,	,
en-wikipedia-org-3485	261	5	Brown	Brown	NNP
en-wikipedia-org-3485	261	6	RY	RY	NNP
en-wikipedia-org-3485	261	7	(	(	-LRB-
en-wikipedia-org-3485	261	8	eds	eds	NNP
en-wikipedia-org-3485	261	9	.	.	.
en-wikipedia-org-3485	261	10	)	)	-RRB-
en-wikipedia-org-3485	261	11	.	.	.
en-wikipedia-org-3485	262	1	Molecular	Molecular	NNP
en-wikipedia-org-3485	262	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-3485	262	3	:	:	:
en-wikipedia-org-3485	262	4	A	A	NNP
en-wikipedia-org-3485	262	5	Foundation	Foundation	NNP
en-wikipedia-org-3485	262	6	for	for	IN
en-wikipedia-org-3485	262	7	Clinical	Clinical	NNP
en-wikipedia-org-3485	262	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	262	9	(	(	-LRB-
en-wikipedia-org-3485	262	10	2nd	2nd	NNP
en-wikipedia-org-3485	262	11	ed	ed	NNP
en-wikipedia-org-3485	262	12	.	.	.
en-wikipedia-org-3485	262	13	)	)	-RRB-
en-wikipedia-org-3485	262	14	.	.	.
en-wikipedia-org-3485	263	1	New	New	NNP
en-wikipedia-org-3485	263	2	York	York	NNP
en-wikipedia-org-3485	263	3	:	:	:
en-wikipedia-org-3485	263	4	McGraw	McGraw	NNP
en-wikipedia-org-3485	263	5	-	-	HYPH
en-wikipedia-org-3485	263	6	Hill	Hill	NNP
en-wikipedia-org-3485	263	7	Medical	Medical	NNP
en-wikipedia-org-3485	263	8	.	.	.
en-wikipedia-org-3485	264	1	pp	pp	NNP
en-wikipedia-org-3485	264	2	.	.	.
en-wikipedia-org-3485	265	1	364–375	364–375	CD
en-wikipedia-org-3485	265	2	.	.	.
en-wikipedia-org-3485	266	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	266	2	 	  	_SP
en-wikipedia-org-3485	266	3	9780071481274	9780071481274	CD
en-wikipedia-org-3485	266	4	.	.	.
en-wikipedia-org-3485	267	1	^	^	NNP
en-wikipedia-org-3485	267	2	a	a	DT
en-wikipedia-org-3485	267	3	b	b	NNP
en-wikipedia-org-3485	267	4	c	c	NNP
en-wikipedia-org-3485	267	5	Nestler	Nestler	NNP
en-wikipedia-org-3485	267	6	EJ	EJ	NNP
en-wikipedia-org-3485	267	7	(	(	-LRB-
en-wikipedia-org-3485	267	8	December	December	NNP
en-wikipedia-org-3485	267	9	2013	2013	CD
en-wikipedia-org-3485	267	10	)	)	-RRB-
en-wikipedia-org-3485	267	11	.	.	.
en-wikipedia-org-3485	268	1	"	"	``
en-wikipedia-org-3485	268	2	Cellular	cellular	JJ
en-wikipedia-org-3485	268	3	basis	basis	NN
en-wikipedia-org-3485	268	4	of	of	IN
en-wikipedia-org-3485	268	5	memory	memory	NN
en-wikipedia-org-3485	268	6	for	for	IN
en-wikipedia-org-3485	268	7	addiction	addiction	NN
en-wikipedia-org-3485	268	8	"	"	''
en-wikipedia-org-3485	268	9	.	.	.
en-wikipedia-org-3485	269	1	Dialogues	dialogue	NNS
en-wikipedia-org-3485	269	2	in	in	IN
en-wikipedia-org-3485	269	3	Clinical	Clinical	NNP
en-wikipedia-org-3485	269	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	269	5	.	.	.
en-wikipedia-org-3485	270	1	15	15	CD
en-wikipedia-org-3485	270	2	(	(	-LRB-
en-wikipedia-org-3485	270	3	4	4	CD
en-wikipedia-org-3485	270	4	)	)	-RRB-
en-wikipedia-org-3485	270	5	:	:	:
en-wikipedia-org-3485	270	6	431–443	431–443	CD
en-wikipedia-org-3485	270	7	.	.	.
en-wikipedia-org-3485	271	1	PMC	PMC	NNP
en-wikipedia-org-3485	271	2	 	  	_SP
en-wikipedia-org-3485	271	3	3898681	3898681	CD
en-wikipedia-org-3485	271	4	.	.	.
en-wikipedia-org-3485	272	1	PMID	PMID	NNP
en-wikipedia-org-3485	272	2	 	  	_SP
en-wikipedia-org-3485	272	3	24459410	24459410	CD
en-wikipedia-org-3485	272	4	.	.	.
en-wikipedia-org-3485	273	1	Despite	despite	IN
en-wikipedia-org-3485	273	2	the	the	DT
en-wikipedia-org-3485	273	3	importance	importance	NN
en-wikipedia-org-3485	273	4	of	of	IN
en-wikipedia-org-3485	273	5	numerous	numerous	JJ
en-wikipedia-org-3485	273	6	psychosocial	psychosocial	JJ
en-wikipedia-org-3485	273	7	factors	factor	NNS
en-wikipedia-org-3485	273	8	,	,	,
en-wikipedia-org-3485	273	9	at	at	IN
en-wikipedia-org-3485	273	10	its	-PRON-	PRP$
en-wikipedia-org-3485	273	11	core	core	NN
en-wikipedia-org-3485	273	12	,	,	,
en-wikipedia-org-3485	273	13	drug	drug	NN
en-wikipedia-org-3485	273	14	addiction	addiction	NN
en-wikipedia-org-3485	273	15	involves	involve	VBZ
en-wikipedia-org-3485	273	16	a	a	DT
en-wikipedia-org-3485	273	17	biological	biological	JJ
en-wikipedia-org-3485	273	18	process	process	NN
en-wikipedia-org-3485	273	19	:	:	:
en-wikipedia-org-3485	273	20	the	the	DT
en-wikipedia-org-3485	273	21	ability	ability	NN
en-wikipedia-org-3485	273	22	of	of	IN
en-wikipedia-org-3485	273	23	repeated	repeat	VBN
en-wikipedia-org-3485	273	24	exposure	exposure	NN
en-wikipedia-org-3485	273	25	to	to	IN
en-wikipedia-org-3485	273	26	a	a	DT
en-wikipedia-org-3485	273	27	drug	drug	NN
en-wikipedia-org-3485	273	28	of	of	IN
en-wikipedia-org-3485	273	29	abuse	abuse	NN
en-wikipedia-org-3485	273	30	to	to	TO
en-wikipedia-org-3485	273	31	induce	induce	VB
en-wikipedia-org-3485	273	32	changes	change	NNS
en-wikipedia-org-3485	273	33	in	in	IN
en-wikipedia-org-3485	273	34	a	a	DT
en-wikipedia-org-3485	273	35	vulnerable	vulnerable	JJ
en-wikipedia-org-3485	273	36	brain	brain	NN
en-wikipedia-org-3485	273	37	that	that	WDT
en-wikipedia-org-3485	273	38	drive	drive	VBP
en-wikipedia-org-3485	273	39	the	the	DT
en-wikipedia-org-3485	273	40	compulsive	compulsive	JJ
en-wikipedia-org-3485	273	41	seeking	seeking	NN
en-wikipedia-org-3485	273	42	and	and	CC
en-wikipedia-org-3485	273	43	taking	taking	NN
en-wikipedia-org-3485	273	44	of	of	IN
en-wikipedia-org-3485	273	45	drugs	drug	NNS
en-wikipedia-org-3485	273	46	,	,	,
en-wikipedia-org-3485	273	47	and	and	CC
en-wikipedia-org-3485	273	48	loss	loss	NN
en-wikipedia-org-3485	273	49	of	of	IN
en-wikipedia-org-3485	273	50	control	control	NN
en-wikipedia-org-3485	273	51	over	over	IN
en-wikipedia-org-3485	273	52	drug	drug	NN
en-wikipedia-org-3485	273	53	use	use	NN
en-wikipedia-org-3485	273	54	,	,	,
en-wikipedia-org-3485	273	55	that	that	WDT
en-wikipedia-org-3485	273	56	define	define	VBP
en-wikipedia-org-3485	273	57	a	a	DT
en-wikipedia-org-3485	273	58	state	state	NN
en-wikipedia-org-3485	273	59	of	of	IN
en-wikipedia-org-3485	273	60	addiction	addiction	NN
en-wikipedia-org-3485	273	61	.	.	.
en-wikipedia-org-3485	274	1	...	...	:
en-wikipedia-org-3485	274	2	A	a	DT
en-wikipedia-org-3485	274	3	large	large	JJ
en-wikipedia-org-3485	274	4	body	body	NN
en-wikipedia-org-3485	274	5	of	of	IN
en-wikipedia-org-3485	274	6	literature	literature	NN
en-wikipedia-org-3485	274	7	has	have	VBZ
en-wikipedia-org-3485	274	8	demonstrated	demonstrate	VBN
en-wikipedia-org-3485	274	9	that	that	IN
en-wikipedia-org-3485	274	10	such	such	JJ
en-wikipedia-org-3485	274	11	ΔFosB	ΔFosB	VBN
en-wikipedia-org-3485	274	12	induction	induction	NN
en-wikipedia-org-3485	274	13	in	in	IN
en-wikipedia-org-3485	274	14	D1-type	D1-type	NNP
en-wikipedia-org-3485	274	15	[	[	-LRB-
en-wikipedia-org-3485	274	16	nucleus	nucleus	NNP
en-wikipedia-org-3485	274	17	accumbens	accumbens	NNPS
en-wikipedia-org-3485	274	18	]	]	-RRB-
en-wikipedia-org-3485	274	19	neurons	neuron	NNS
en-wikipedia-org-3485	274	20	increases	increase	VBZ
en-wikipedia-org-3485	274	21	an	an	DT
en-wikipedia-org-3485	274	22	animal	animal	NN
en-wikipedia-org-3485	274	23	's	's	POS
en-wikipedia-org-3485	274	24	sensitivity	sensitivity	NN
en-wikipedia-org-3485	274	25	to	to	IN
en-wikipedia-org-3485	274	26	drug	drug	NN
en-wikipedia-org-3485	274	27	as	as	RB
en-wikipedia-org-3485	274	28	well	well	RB
en-wikipedia-org-3485	274	29	as	as	IN
en-wikipedia-org-3485	274	30	natural	natural	JJ
en-wikipedia-org-3485	274	31	rewards	reward	NNS
en-wikipedia-org-3485	274	32	and	and	CC
en-wikipedia-org-3485	274	33	promotes	promote	VBZ
en-wikipedia-org-3485	274	34	drug	drug	NN
en-wikipedia-org-3485	274	35	self	self	NN
en-wikipedia-org-3485	274	36	-	-	HYPH
en-wikipedia-org-3485	274	37	administration	administration	NN
en-wikipedia-org-3485	274	38	,	,	,
en-wikipedia-org-3485	274	39	presumably	presumably	RB
en-wikipedia-org-3485	274	40	through	through	IN
en-wikipedia-org-3485	274	41	a	a	DT
en-wikipedia-org-3485	274	42	process	process	NN
en-wikipedia-org-3485	274	43	of	of	IN
en-wikipedia-org-3485	274	44	positive	positive	JJ
en-wikipedia-org-3485	274	45	reinforcement	reinforcement	NN
en-wikipedia-org-3485	274	46	 	  	_SP
en-wikipedia-org-3485	274	47	...	...	:
en-wikipedia-org-3485	274	48	Another	another	DT
en-wikipedia-org-3485	274	49	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	274	50	target	target	NN
en-wikipedia-org-3485	274	51	is	be	VBZ
en-wikipedia-org-3485	274	52	cFos	cFos	NNP
en-wikipedia-org-3485	274	53	:	:	:
en-wikipedia-org-3485	274	54	as	as	IN
en-wikipedia-org-3485	274	55	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	274	56	accumulates	accumulate	NNS
en-wikipedia-org-3485	274	57	with	with	IN
en-wikipedia-org-3485	274	58	repeated	repeat	VBN
en-wikipedia-org-3485	274	59	drug	drug	NN
en-wikipedia-org-3485	274	60	exposure	exposure	NN
en-wikipedia-org-3485	274	61	it	-PRON-	PRP
en-wikipedia-org-3485	274	62	represses	repress	VBZ
en-wikipedia-org-3485	274	63	c	c	NN
en-wikipedia-org-3485	274	64	-	-	:
en-wikipedia-org-3485	274	65	Fos	fos	NN
en-wikipedia-org-3485	274	66	and	and	CC
en-wikipedia-org-3485	274	67	contributes	contribute	VBZ
en-wikipedia-org-3485	274	68	to	to	IN
en-wikipedia-org-3485	274	69	the	the	DT
en-wikipedia-org-3485	274	70	molecular	molecular	JJ
en-wikipedia-org-3485	274	71	switch	switch	NN
en-wikipedia-org-3485	274	72	whereby	whereby	WRB
en-wikipedia-org-3485	274	73	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	274	74	is	be	VBZ
en-wikipedia-org-3485	274	75	selectively	selectively	RB
en-wikipedia-org-3485	274	76	induced	induce	VBN
en-wikipedia-org-3485	274	77	in	in	IN
en-wikipedia-org-3485	274	78	the	the	DT
en-wikipedia-org-3485	274	79	chronic	chronic	JJ
en-wikipedia-org-3485	274	80	drug	drug	NN
en-wikipedia-org-3485	274	81	-	-	HYPH
en-wikipedia-org-3485	274	82	treated	treat	VBN
en-wikipedia-org-3485	274	83	state.41	state.41	NNP
en-wikipedia-org-3485	274	84	.	.	.
en-wikipedia-org-3485	275	1	...	...	NFP
en-wikipedia-org-3485	276	1	Moreover	moreover	RB
en-wikipedia-org-3485	276	2	,	,	,
en-wikipedia-org-3485	276	3	there	there	EX
en-wikipedia-org-3485	276	4	is	be	VBZ
en-wikipedia-org-3485	276	5	increasing	increase	VBG
en-wikipedia-org-3485	276	6	evidence	evidence	NN
en-wikipedia-org-3485	276	7	that	that	IN
en-wikipedia-org-3485	276	8	,	,	,
en-wikipedia-org-3485	276	9	despite	despite	IN
en-wikipedia-org-3485	276	10	a	a	DT
en-wikipedia-org-3485	276	11	range	range	NN
en-wikipedia-org-3485	276	12	of	of	IN
en-wikipedia-org-3485	276	13	genetic	genetic	JJ
en-wikipedia-org-3485	276	14	risks	risk	NNS
en-wikipedia-org-3485	276	15	for	for	IN
en-wikipedia-org-3485	276	16	addiction	addiction	NN
en-wikipedia-org-3485	276	17	across	across	IN
en-wikipedia-org-3485	276	18	the	the	DT
en-wikipedia-org-3485	276	19	population	population	NN
en-wikipedia-org-3485	276	20	,	,	,
en-wikipedia-org-3485	276	21	exposure	exposure	NN
en-wikipedia-org-3485	276	22	to	to	IN
en-wikipedia-org-3485	276	23	sufficiently	sufficiently	RB
en-wikipedia-org-3485	276	24	high	high	JJ
en-wikipedia-org-3485	276	25	doses	dose	NNS
en-wikipedia-org-3485	276	26	of	of	IN
en-wikipedia-org-3485	276	27	a	a	DT
en-wikipedia-org-3485	276	28	drug	drug	NN
en-wikipedia-org-3485	276	29	for	for	IN
en-wikipedia-org-3485	276	30	long	long	JJ
en-wikipedia-org-3485	276	31	periods	period	NNS
en-wikipedia-org-3485	276	32	of	of	IN
en-wikipedia-org-3485	276	33	time	time	NN
en-wikipedia-org-3485	276	34	can	can	MD
en-wikipedia-org-3485	276	35	transform	transform	VB
en-wikipedia-org-3485	276	36	someone	someone	NN
en-wikipedia-org-3485	276	37	who	who	WP
en-wikipedia-org-3485	276	38	has	have	VBZ
en-wikipedia-org-3485	276	39	relatively	relatively	RB
en-wikipedia-org-3485	276	40	lower	low	JJR
en-wikipedia-org-3485	276	41	genetic	genetic	JJ
en-wikipedia-org-3485	276	42	loading	loading	NN
en-wikipedia-org-3485	276	43	into	into	IN
en-wikipedia-org-3485	276	44	an	an	DT
en-wikipedia-org-3485	276	45	addict	addict	NN
en-wikipedia-org-3485	276	46	.	.	.
en-wikipedia-org-3485	277	1	^	^	FW
en-wikipedia-org-3485	277	2	"	"	``
en-wikipedia-org-3485	277	3	Glossary	Glossary	NNP
en-wikipedia-org-3485	277	4	of	of	IN
en-wikipedia-org-3485	277	5	Terms	Terms	NNPS
en-wikipedia-org-3485	277	6	"	"	''
en-wikipedia-org-3485	277	7	.	.	.
en-wikipedia-org-3485	278	1	Mount	Mount	NNP
en-wikipedia-org-3485	278	2	Sinai	Sinai	NNP
en-wikipedia-org-3485	278	3	School	School	NNP
en-wikipedia-org-3485	278	4	of	of	IN
en-wikipedia-org-3485	278	5	Medicine	Medicine	NNP
en-wikipedia-org-3485	278	6	.	.	.
en-wikipedia-org-3485	279	1	Department	Department	NNP
en-wikipedia-org-3485	279	2	of	of	IN
en-wikipedia-org-3485	279	3	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	279	4	.	.	.
en-wikipedia-org-3485	280	1	Retrieved	Retrieved	NNP
en-wikipedia-org-3485	280	2	9	9	CD
en-wikipedia-org-3485	280	3	February	February	NNP
en-wikipedia-org-3485	280	4	2015	2015	CD
en-wikipedia-org-3485	280	5	.	.	.
en-wikipedia-org-3485	281	1	^	^	NNP
en-wikipedia-org-3485	281	2	Volkow	Volkow	NNP
en-wikipedia-org-3485	281	3	ND	ND	NNP
en-wikipedia-org-3485	281	4	,	,	,
en-wikipedia-org-3485	281	5	Koob	Koob	NNP
en-wikipedia-org-3485	281	6	GF	GF	NNP
en-wikipedia-org-3485	281	7	,	,	,
en-wikipedia-org-3485	281	8	McLellan	McLellan	NNP
en-wikipedia-org-3485	281	9	AT	AT	NNP
en-wikipedia-org-3485	281	10	(	(	-LRB-
en-wikipedia-org-3485	281	11	January	January	NNP
en-wikipedia-org-3485	281	12	2016	2016	CD
en-wikipedia-org-3485	281	13	)	)	-RRB-
en-wikipedia-org-3485	281	14	.	.	.
en-wikipedia-org-3485	282	1	"	"	``
en-wikipedia-org-3485	282	2	Neurobiologic	Neurobiologic	NNP
en-wikipedia-org-3485	282	3	Advances	Advances	NNPS
en-wikipedia-org-3485	282	4	from	from	IN
en-wikipedia-org-3485	282	5	the	the	DT
en-wikipedia-org-3485	282	6	Brain	Brain	NNP
en-wikipedia-org-3485	282	7	Disease	Disease	NNP
en-wikipedia-org-3485	282	8	Model	Model	NNP
en-wikipedia-org-3485	282	9	of	of	IN
en-wikipedia-org-3485	282	10	Addiction	Addiction	NNP
en-wikipedia-org-3485	282	11	"	"	''
en-wikipedia-org-3485	282	12	.	.	.
en-wikipedia-org-3485	283	1	New	New	NNP
en-wikipedia-org-3485	283	2	England	England	NNP
en-wikipedia-org-3485	283	3	Journal	Journal	NNP
en-wikipedia-org-3485	283	4	of	of	IN
en-wikipedia-org-3485	283	5	Medicine	Medicine	NNP
en-wikipedia-org-3485	283	6	.	.	.
en-wikipedia-org-3485	284	1	374	374	CD
en-wikipedia-org-3485	284	2	(	(	-LRB-
en-wikipedia-org-3485	284	3	4	4	CD
en-wikipedia-org-3485	284	4	)	)	-RRB-
en-wikipedia-org-3485	284	5	:	:	:
en-wikipedia-org-3485	284	6	363–371	363–371	CD
en-wikipedia-org-3485	284	7	.	.	.
en-wikipedia-org-3485	285	1	doi:10.1056	doi:10.1056	NNP
en-wikipedia-org-3485	285	2	/	/	SYM
en-wikipedia-org-3485	285	3	NEJMra1511480	nejmra1511480	UH
en-wikipedia-org-3485	285	4	.	.	.
en-wikipedia-org-3485	286	1	PMC	PMC	NNP
en-wikipedia-org-3485	286	2	 	  	_SP
en-wikipedia-org-3485	286	3	6135257	6135257	CD
en-wikipedia-org-3485	286	4	.	.	.
en-wikipedia-org-3485	287	1	PMID	PMID	NNP
en-wikipedia-org-3485	287	2	 	  	_SP
en-wikipedia-org-3485	287	3	26816013	26816013	CD
en-wikipedia-org-3485	287	4	.	.	.
en-wikipedia-org-3485	288	1	Substance	substance	NN
en-wikipedia-org-3485	288	2	-	-	HYPH
en-wikipedia-org-3485	288	3	use	use	NN
en-wikipedia-org-3485	288	4	disorder	disorder	NN
en-wikipedia-org-3485	288	5	:	:	:
en-wikipedia-org-3485	288	6	A	a	DT
en-wikipedia-org-3485	288	7	diagnostic	diagnostic	JJ
en-wikipedia-org-3485	288	8	term	term	NN
en-wikipedia-org-3485	288	9	in	in	IN
en-wikipedia-org-3485	288	10	the	the	DT
en-wikipedia-org-3485	288	11	fifth	fifth	JJ
en-wikipedia-org-3485	288	12	edition	edition	NN
en-wikipedia-org-3485	288	13	of	of	IN
en-wikipedia-org-3485	288	14	the	the	DT
en-wikipedia-org-3485	288	15	Diagnostic	Diagnostic	NNP
en-wikipedia-org-3485	288	16	and	and	CC
en-wikipedia-org-3485	288	17	Statistical	Statistical	NNP
en-wikipedia-org-3485	288	18	Manual	Manual	NNP
en-wikipedia-org-3485	288	19	of	of	IN
en-wikipedia-org-3485	288	20	Mental	Mental	NNP
en-wikipedia-org-3485	288	21	Disorders	Disorders	NNPS
en-wikipedia-org-3485	288	22	(	(	-LRB-
en-wikipedia-org-3485	288	23	DSM-5	DSM-5	NNP
en-wikipedia-org-3485	288	24	)	)	-RRB-
en-wikipedia-org-3485	288	25	referring	refer	VBG
en-wikipedia-org-3485	288	26	to	to	IN
en-wikipedia-org-3485	288	27	recurrent	recurrent	JJ
en-wikipedia-org-3485	288	28	use	use	NN
en-wikipedia-org-3485	288	29	of	of	IN
en-wikipedia-org-3485	288	30	alcohol	alcohol	NN
en-wikipedia-org-3485	288	31	or	or	CC
en-wikipedia-org-3485	288	32	other	other	JJ
en-wikipedia-org-3485	288	33	drugs	drug	NNS
en-wikipedia-org-3485	288	34	that	that	WDT
en-wikipedia-org-3485	288	35	causes	cause	VBZ
en-wikipedia-org-3485	288	36	clinically	clinically	RB
en-wikipedia-org-3485	288	37	and	and	CC
en-wikipedia-org-3485	288	38	functionally	functionally	RB
en-wikipedia-org-3485	288	39	significant	significant	JJ
en-wikipedia-org-3485	288	40	impairment	impairment	NN
en-wikipedia-org-3485	288	41	,	,	,
en-wikipedia-org-3485	288	42	such	such	JJ
en-wikipedia-org-3485	288	43	as	as	IN
en-wikipedia-org-3485	288	44	health	health	NN
en-wikipedia-org-3485	288	45	problems	problem	NNS
en-wikipedia-org-3485	288	46	,	,	,
en-wikipedia-org-3485	288	47	disability	disability	NN
en-wikipedia-org-3485	288	48	,	,	,
en-wikipedia-org-3485	288	49	and	and	CC
en-wikipedia-org-3485	288	50	failure	failure	NN
en-wikipedia-org-3485	288	51	to	to	TO
en-wikipedia-org-3485	288	52	meet	meet	VB
en-wikipedia-org-3485	288	53	major	major	JJ
en-wikipedia-org-3485	288	54	responsibilities	responsibility	NNS
en-wikipedia-org-3485	288	55	at	at	IN
en-wikipedia-org-3485	288	56	work	work	NN
en-wikipedia-org-3485	288	57	,	,	,
en-wikipedia-org-3485	288	58	school	school	NN
en-wikipedia-org-3485	288	59	,	,	,
en-wikipedia-org-3485	288	60	or	or	CC
en-wikipedia-org-3485	288	61	home	home	NN
en-wikipedia-org-3485	288	62	.	.	.
en-wikipedia-org-3485	289	1	Depending	depend	VBG
en-wikipedia-org-3485	289	2	on	on	IN
en-wikipedia-org-3485	289	3	the	the	DT
en-wikipedia-org-3485	289	4	level	level	NN
en-wikipedia-org-3485	289	5	of	of	IN
en-wikipedia-org-3485	289	6	severity	severity	NN
en-wikipedia-org-3485	289	7	,	,	,
en-wikipedia-org-3485	289	8	this	this	DT
en-wikipedia-org-3485	289	9	disorder	disorder	NN
en-wikipedia-org-3485	289	10	is	be	VBZ
en-wikipedia-org-3485	289	11	classified	classify	VBN
en-wikipedia-org-3485	289	12	as	as	IN
en-wikipedia-org-3485	289	13	mild	mild	JJ
en-wikipedia-org-3485	289	14	,	,	,
en-wikipedia-org-3485	289	15	moderate	moderate	JJ
en-wikipedia-org-3485	289	16	,	,	,
en-wikipedia-org-3485	289	17	or	or	CC
en-wikipedia-org-3485	289	18	severe	severe	JJ
en-wikipedia-org-3485	289	19	.	.	.
en-wikipedia-org-3485	290	1	Addiction	addiction	NN
en-wikipedia-org-3485	290	2	:	:	:
en-wikipedia-org-3485	290	3	A	a	DT
en-wikipedia-org-3485	290	4	term	term	NN
en-wikipedia-org-3485	290	5	used	use	VBN
en-wikipedia-org-3485	290	6	to	to	TO
en-wikipedia-org-3485	290	7	indicate	indicate	VB
en-wikipedia-org-3485	290	8	the	the	DT
en-wikipedia-org-3485	290	9	most	most	RBS
en-wikipedia-org-3485	290	10	severe	severe	JJ
en-wikipedia-org-3485	290	11	,	,	,
en-wikipedia-org-3485	290	12	chronic	chronic	JJ
en-wikipedia-org-3485	290	13	stage	stage	NN
en-wikipedia-org-3485	290	14	of	of	IN
en-wikipedia-org-3485	290	15	substance	substance	NN
en-wikipedia-org-3485	290	16	-	-	HYPH
en-wikipedia-org-3485	290	17	use	use	NN
en-wikipedia-org-3485	290	18	disorder	disorder	NN
en-wikipedia-org-3485	290	19	,	,	,
en-wikipedia-org-3485	290	20	in	in	IN
en-wikipedia-org-3485	290	21	which	which	WDT
en-wikipedia-org-3485	290	22	there	there	EX
en-wikipedia-org-3485	290	23	is	be	VBZ
en-wikipedia-org-3485	290	24	a	a	DT
en-wikipedia-org-3485	290	25	substantial	substantial	JJ
en-wikipedia-org-3485	290	26	loss	loss	NN
en-wikipedia-org-3485	290	27	of	of	IN
en-wikipedia-org-3485	290	28	self	self	NN
en-wikipedia-org-3485	290	29	-	-	HYPH
en-wikipedia-org-3485	290	30	control	control	NN
en-wikipedia-org-3485	290	31	,	,	,
en-wikipedia-org-3485	290	32	as	as	IN
en-wikipedia-org-3485	290	33	indicated	indicate	VBN
en-wikipedia-org-3485	290	34	by	by	IN
en-wikipedia-org-3485	290	35	compulsive	compulsive	JJ
en-wikipedia-org-3485	290	36	drug	drug	NN
en-wikipedia-org-3485	290	37	taking	take	VBG
en-wikipedia-org-3485	290	38	despite	despite	IN
en-wikipedia-org-3485	290	39	the	the	DT
en-wikipedia-org-3485	290	40	desire	desire	NN
en-wikipedia-org-3485	290	41	to	to	TO
en-wikipedia-org-3485	290	42	stop	stop	VB
en-wikipedia-org-3485	290	43	taking	take	VBG
en-wikipedia-org-3485	290	44	the	the	DT
en-wikipedia-org-3485	290	45	drug	drug	NN
en-wikipedia-org-3485	290	46	.	.	.
en-wikipedia-org-3485	291	1	In	in	IN
en-wikipedia-org-3485	291	2	the	the	DT
en-wikipedia-org-3485	291	3	DSM-5	DSM-5	NNP
en-wikipedia-org-3485	291	4	,	,	,
en-wikipedia-org-3485	291	5	the	the	DT
en-wikipedia-org-3485	291	6	term	term	NN
en-wikipedia-org-3485	291	7	addiction	addiction	NN
en-wikipedia-org-3485	291	8	is	be	VBZ
en-wikipedia-org-3485	291	9	synonymous	synonymous	JJ
en-wikipedia-org-3485	291	10	with	with	IN
en-wikipedia-org-3485	291	11	the	the	DT
en-wikipedia-org-3485	291	12	classification	classification	NN
en-wikipedia-org-3485	291	13	of	of	IN
en-wikipedia-org-3485	291	14	severe	severe	JJ
en-wikipedia-org-3485	291	15	substance	substance	NN
en-wikipedia-org-3485	291	16	-	-	HYPH
en-wikipedia-org-3485	291	17	use	use	NN
en-wikipedia-org-3485	291	18	disorder	disorder	NN
en-wikipedia-org-3485	291	19	.	.	.
en-wikipedia-org-3485	292	1	^	^	NNP
en-wikipedia-org-3485	292	2	a	a	DT
en-wikipedia-org-3485	292	3	b	b	NNP
en-wikipedia-org-3485	292	4	c	c	NN
en-wikipedia-org-3485	292	5	d	d	NNP
en-wikipedia-org-3485	292	6	e	e	NN
en-wikipedia-org-3485	292	7	Kolb	Kolb	NNP
en-wikipedia-org-3485	292	8	B	B	NNP
en-wikipedia-org-3485	292	9	,	,	,
en-wikipedia-org-3485	292	10	Whishaw	Whishaw	NNP
en-wikipedia-org-3485	292	11	IQ	IQ	NNP
en-wikipedia-org-3485	292	12	(	(	-LRB-
en-wikipedia-org-3485	292	13	2001	2001	CD
en-wikipedia-org-3485	292	14	)	)	-RRB-
en-wikipedia-org-3485	292	15	.	.	.
en-wikipedia-org-3485	293	1	An	an	DT
en-wikipedia-org-3485	293	2	Introduction	introduction	NN
en-wikipedia-org-3485	293	3	to	to	IN
en-wikipedia-org-3485	293	4	Brain	Brain	NNP
en-wikipedia-org-3485	293	5	and	and	CC
en-wikipedia-org-3485	293	6	Behavior	Behavior	NNP
en-wikipedia-org-3485	293	7	(	(	-LRB-
en-wikipedia-org-3485	293	8	1st	1st	NNP
en-wikipedia-org-3485	293	9	ed	ed	NNP
en-wikipedia-org-3485	293	10	.	.	.
en-wikipedia-org-3485	293	11	)	)	-RRB-
en-wikipedia-org-3485	293	12	.	.	.
en-wikipedia-org-3485	294	1	New	New	NNP
en-wikipedia-org-3485	294	2	York	York	NNP
en-wikipedia-org-3485	294	3	:	:	:
en-wikipedia-org-3485	294	4	Worth	worth	JJ
en-wikipedia-org-3485	294	5	.	.	.
en-wikipedia-org-3485	295	1	pp	pp	NNP
en-wikipedia-org-3485	295	2	.	.	.
en-wikipedia-org-3485	296	1	438–441	438–441	CD
en-wikipedia-org-3485	296	2	.	.	.
en-wikipedia-org-3485	297	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	297	2	 	  	_SP
en-wikipedia-org-3485	297	3	9780716751694	9780716751694	CD
en-wikipedia-org-3485	297	4	.	.	.
en-wikipedia-org-3485	298	1	^	^	NNP
en-wikipedia-org-3485	298	2	https://youtube.com/NQBoNcr8qIk?t=309	https://youtube.com/nqboncr8qik?t=309	PRP
en-wikipedia-org-3485	298	3	^	^	FW
en-wikipedia-org-3485	298	4	"	"	``
en-wikipedia-org-3485	298	5	Dopamine	dopamine	NN
en-wikipedia-org-3485	298	6	Involved	involve	VBN
en-wikipedia-org-3485	298	7	In	in	IN
en-wikipedia-org-3485	298	8	Aggression	Aggression	NNP
en-wikipedia-org-3485	298	9	"	"	''
en-wikipedia-org-3485	298	10	.	.	.
en-wikipedia-org-3485	299	1	Medical	Medical	NNP
en-wikipedia-org-3485	299	2	News	News	NNP
en-wikipedia-org-3485	299	3	Today	Today	NNP
en-wikipedia-org-3485	299	4	.	.	.
en-wikipedia-org-3485	300	1	15	15	CD
en-wikipedia-org-3485	300	2	January	January	NNP
en-wikipedia-org-3485	300	3	2008	2008	CD
en-wikipedia-org-3485	300	4	.	.	.
en-wikipedia-org-3485	301	1	Retrieved	retrieve	VBN
en-wikipedia-org-3485	301	2	14	14	CD
en-wikipedia-org-3485	301	3	November	November	NNP
en-wikipedia-org-3485	301	4	2010	2010	CD
en-wikipedia-org-3485	301	5	.	.	.
en-wikipedia-org-3485	302	1	^	^	NNP
en-wikipedia-org-3485	302	2	Duarte	Duarte	NNP
en-wikipedia-org-3485	302	3	,	,	,
en-wikipedia-org-3485	302	4	Isabel	Isabel	NNP
en-wikipedia-org-3485	302	5	C.	C.	NNP
en-wikipedia-org-3485	302	6	;	;	:
en-wikipedia-org-3485	302	7	Afonso	Afonso	NNP
en-wikipedia-org-3485	302	8	,	,	,
en-wikipedia-org-3485	302	9	Sónia	Sónia	NNP
en-wikipedia-org-3485	302	10	;	;	:
en-wikipedia-org-3485	302	11	Jorge	Jorge	NNP
en-wikipedia-org-3485	302	12	,	,	,
en-wikipedia-org-3485	302	13	Helena	Helena	NNP
en-wikipedia-org-3485	302	14	;	;	:
en-wikipedia-org-3485	302	15	Cayolla	Cayolla	NNP
en-wikipedia-org-3485	302	16	,	,	,
en-wikipedia-org-3485	302	17	Ricardo	Ricardo	NNP
en-wikipedia-org-3485	302	18	;	;	:
en-wikipedia-org-3485	302	19	Ferreira	Ferreira	NNP
en-wikipedia-org-3485	302	20	,	,	,
en-wikipedia-org-3485	302	21	Carlos	Carlos	NNP
en-wikipedia-org-3485	302	22	;	;	:
en-wikipedia-org-3485	302	23	Castelo	Castelo	NNP
en-wikipedia-org-3485	302	24	-	-	HYPH
en-wikipedia-org-3485	302	25	Branco	Branco	NNP
en-wikipedia-org-3485	302	26	,	,	,
en-wikipedia-org-3485	302	27	Miguel	Miguel	NNP
en-wikipedia-org-3485	302	28	(	(	-LRB-
en-wikipedia-org-3485	302	29	1	1	CD
en-wikipedia-org-3485	302	30	May	May	NNP
en-wikipedia-org-3485	302	31	2017	2017	CD
en-wikipedia-org-3485	302	32	)	)	-RRB-
en-wikipedia-org-3485	302	33	.	.	.
en-wikipedia-org-3485	303	1	"	"	``
en-wikipedia-org-3485	303	2	Tribal	tribal	JJ
en-wikipedia-org-3485	303	3	love	love	NN
en-wikipedia-org-3485	303	4	:	:	:
en-wikipedia-org-3485	303	5	the	the	DT
en-wikipedia-org-3485	303	6	neural	neural	JJ
en-wikipedia-org-3485	303	7	correlates	correlates	NNPS
en-wikipedia-org-3485	303	8	of	of	IN
en-wikipedia-org-3485	303	9	passionate	passionate	JJ
en-wikipedia-org-3485	303	10	engagement	engagement	NN
en-wikipedia-org-3485	303	11	in	in	IN
en-wikipedia-org-3485	303	12	football	football	NN
en-wikipedia-org-3485	303	13	fans	fan	NNS
en-wikipedia-org-3485	303	14	"	"	''
en-wikipedia-org-3485	303	15	.	.	.
en-wikipedia-org-3485	304	1	Social	Social	NNP
en-wikipedia-org-3485	304	2	Cognitive	Cognitive	NNP
en-wikipedia-org-3485	304	3	and	and	CC
en-wikipedia-org-3485	304	4	Affective	Affective	NNP
en-wikipedia-org-3485	304	5	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	304	6	.	.	.
en-wikipedia-org-3485	305	1	12	12	CD
en-wikipedia-org-3485	305	2	(	(	-LRB-
en-wikipedia-org-3485	305	3	5	5	CD
en-wikipedia-org-3485	305	4	)	)	-RRB-
en-wikipedia-org-3485	305	5	:	:	:
en-wikipedia-org-3485	305	6	718–728	718–728	CD
en-wikipedia-org-3485	305	7	.	.	.
en-wikipedia-org-3485	306	1	doi:10.1093	doi:10.1093	NNP
en-wikipedia-org-3485	306	2	/	/	SYM
en-wikipedia-org-3485	306	3	scan	scan	NNP
en-wikipedia-org-3485	306	4	/	/	SYM
en-wikipedia-org-3485	306	5	nsx003	nsx003	NNP
en-wikipedia-org-3485	306	6	.	.	.
en-wikipedia-org-3485	307	1	PMC	PMC	NNP
en-wikipedia-org-3485	307	2	 	  	_SP
en-wikipedia-org-3485	307	3	5460049	5460049	CD
en-wikipedia-org-3485	307	4	.	.	.
en-wikipedia-org-3485	308	1	PMID	PMID	NNP
en-wikipedia-org-3485	308	2	 	  	_SP
en-wikipedia-org-3485	308	3	28338882	28338882	CD
en-wikipedia-org-3485	308	4	.	.	.
en-wikipedia-org-3485	309	1	^	^	NNP
en-wikipedia-org-3485	309	2	a	a	DT
en-wikipedia-org-3485	309	3	b	b	NNP
en-wikipedia-org-3485	309	4	c	c	NNP
en-wikipedia-org-3485	309	5	Salamone	Salamone	NNP
en-wikipedia-org-3485	309	6	,	,	,
en-wikipedia-org-3485	309	7	John	John	NNP
en-wikipedia-org-3485	309	8	D.	D.	NNP
en-wikipedia-org-3485	309	9	;	;	:
en-wikipedia-org-3485	309	10	Correa	Correa	NNP
en-wikipedia-org-3485	309	11	,	,	,
en-wikipedia-org-3485	309	12	Mercè	Mercè	NNP
en-wikipedia-org-3485	309	13	(	(	-LRB-
en-wikipedia-org-3485	309	14	November	November	NNP
en-wikipedia-org-3485	309	15	2012	2012	CD
en-wikipedia-org-3485	309	16	)	)	-RRB-
en-wikipedia-org-3485	309	17	.	.	.
en-wikipedia-org-3485	310	1	"	"	``
en-wikipedia-org-3485	310	2	The	the	DT
en-wikipedia-org-3485	310	3	Mysterious	Mysterious	NNP
en-wikipedia-org-3485	310	4	Motivational	Motivational	NNP
en-wikipedia-org-3485	310	5	Functions	Functions	NNPS
en-wikipedia-org-3485	310	6	of	of	IN
en-wikipedia-org-3485	310	7	Mesolimbic	Mesolimbic	NNP
en-wikipedia-org-3485	310	8	Dopamine	Dopamine	NNP
en-wikipedia-org-3485	310	9	"	"	''
en-wikipedia-org-3485	310	10	.	.	.
en-wikipedia-org-3485	311	1	Neuron	neuron	UH
en-wikipedia-org-3485	311	2	.	.	.
en-wikipedia-org-3485	312	1	76	76	CD
en-wikipedia-org-3485	312	2	(	(	-LRB-
en-wikipedia-org-3485	312	3	3	3	CD
en-wikipedia-org-3485	312	4	)	)	-RRB-
en-wikipedia-org-3485	312	5	:	:	:
en-wikipedia-org-3485	312	6	470–485	470–485	CD
en-wikipedia-org-3485	312	7	.	.	.
en-wikipedia-org-3485	313	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	313	2	/	/	SYM
en-wikipedia-org-3485	313	3	j.neuron.2012.10.021	j.neuron.2012.10.021	CD
en-wikipedia-org-3485	313	4	.	.	.
en-wikipedia-org-3485	314	1	PMC	PMC	NNP
en-wikipedia-org-3485	314	2	 	  	_SP
en-wikipedia-org-3485	314	3	4450094	4450094	CD
en-wikipedia-org-3485	314	4	.	.	.
en-wikipedia-org-3485	315	1	PMID	PMID	NNP
en-wikipedia-org-3485	315	2	 	  	_SP
en-wikipedia-org-3485	315	3	23141060	23141060	CD
en-wikipedia-org-3485	315	4	.	.	.
en-wikipedia-org-3485	316	1	^	^	NNP
en-wikipedia-org-3485	316	2	a	a	DT
en-wikipedia-org-3485	316	3	b	b	NNP
en-wikipedia-org-3485	316	4	c	c	NNP
en-wikipedia-org-3485	316	5	d	d	NNP
en-wikipedia-org-3485	316	6	e	e	NNP
en-wikipedia-org-3485	316	7	f	f	NNP
en-wikipedia-org-3485	316	8	g	g	NNP
en-wikipedia-org-3485	316	9	Yager	Yager	NNP
en-wikipedia-org-3485	316	10	LM	LM	NNP
en-wikipedia-org-3485	316	11	,	,	,
en-wikipedia-org-3485	316	12	Garcia	Garcia	NNP
en-wikipedia-org-3485	316	13	AF	AF	NNP
en-wikipedia-org-3485	316	14	,	,	,
en-wikipedia-org-3485	316	15	Wunsch	Wunsch	NNP
en-wikipedia-org-3485	316	16	AM	AM	NNP
en-wikipedia-org-3485	316	17	,	,	,
en-wikipedia-org-3485	316	18	Ferguson	Ferguson	NNP
en-wikipedia-org-3485	316	19	SM	SM	NNP
en-wikipedia-org-3485	316	20	(	(	-LRB-
en-wikipedia-org-3485	316	21	August	August	NNP
en-wikipedia-org-3485	316	22	2015	2015	CD
en-wikipedia-org-3485	316	23	)	)	-RRB-
en-wikipedia-org-3485	316	24	.	.	.
en-wikipedia-org-3485	317	1	"	"	``
en-wikipedia-org-3485	317	2	The	the	DT
en-wikipedia-org-3485	317	3	ins	in	NNS
en-wikipedia-org-3485	317	4	and	and	CC
en-wikipedia-org-3485	317	5	outs	out	NNS
en-wikipedia-org-3485	317	6	of	of	IN
en-wikipedia-org-3485	317	7	the	the	DT
en-wikipedia-org-3485	317	8	striatum	striatum	NN
en-wikipedia-org-3485	317	9	:	:	:
en-wikipedia-org-3485	317	10	Role	role	NN
en-wikipedia-org-3485	317	11	in	in	IN
en-wikipedia-org-3485	317	12	drug	drug	NN
en-wikipedia-org-3485	317	13	addiction	addiction	NN
en-wikipedia-org-3485	317	14	"	"	''
en-wikipedia-org-3485	317	15	.	.	.
en-wikipedia-org-3485	318	1	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	318	2	.	.	.
en-wikipedia-org-3485	319	1	301	301	CD
en-wikipedia-org-3485	319	2	:	:	:
en-wikipedia-org-3485	319	3	529–541	529–541	CD
en-wikipedia-org-3485	319	4	.	.	.
en-wikipedia-org-3485	320	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	320	2	/	/	SYM
en-wikipedia-org-3485	320	3	j.neuroscience.2015.06.033	j.neuroscience.2015.06.033	CD
en-wikipedia-org-3485	320	4	.	.	.
en-wikipedia-org-3485	321	1	PMC	PMC	NNP
en-wikipedia-org-3485	321	2	 	  	_SP
en-wikipedia-org-3485	321	3	4523218	4523218	CD
en-wikipedia-org-3485	321	4	.	.	.
en-wikipedia-org-3485	322	1	PMID	PMID	NNP
en-wikipedia-org-3485	322	2	 	  	_SP
en-wikipedia-org-3485	322	3	26116518	26116518	CD
en-wikipedia-org-3485	322	4	.	.	.
en-wikipedia-org-3485	323	1	[	[	-LRB-
en-wikipedia-org-3485	323	2	The	the	DT
en-wikipedia-org-3485	323	3	striatum	striatum	NN
en-wikipedia-org-3485	323	4	]	]	-RRB-
en-wikipedia-org-3485	323	5	receives	receive	VBZ
en-wikipedia-org-3485	323	6	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	323	7	inputs	input	NNS
en-wikipedia-org-3485	323	8	from	from	IN
en-wikipedia-org-3485	323	9	the	the	DT
en-wikipedia-org-3485	323	10	ventral	ventral	JJ
en-wikipedia-org-3485	323	11	tegmental	tegmental	JJ
en-wikipedia-org-3485	323	12	area	area	NN
en-wikipedia-org-3485	323	13	(	(	-LRB-
en-wikipedia-org-3485	323	14	VTA	VTA	NNP
en-wikipedia-org-3485	323	15	)	)	-RRB-
en-wikipedia-org-3485	323	16	and	and	CC
en-wikipedia-org-3485	323	17	the	the	DT
en-wikipedia-org-3485	323	18	substantia	substantia	NN
en-wikipedia-org-3485	323	19	nigra	nigra	NNP
en-wikipedia-org-3485	323	20	(	(	-LRB-
en-wikipedia-org-3485	323	21	SNr	SNr	NNP
en-wikipedia-org-3485	323	22	)	)	-RRB-
en-wikipedia-org-3485	323	23	and	and	CC
en-wikipedia-org-3485	323	24	glutamatergic	glutamatergic	JJ
en-wikipedia-org-3485	323	25	inputs	input	NNS
en-wikipedia-org-3485	323	26	from	from	IN
en-wikipedia-org-3485	323	27	several	several	JJ
en-wikipedia-org-3485	323	28	areas	area	NNS
en-wikipedia-org-3485	323	29	,	,	,
en-wikipedia-org-3485	323	30	including	include	VBG
en-wikipedia-org-3485	323	31	the	the	DT
en-wikipedia-org-3485	323	32	cortex	cortex	NNP
en-wikipedia-org-3485	323	33	,	,	,
en-wikipedia-org-3485	323	34	hippocampus	hippocampus	NNP
en-wikipedia-org-3485	323	35	,	,	,
en-wikipedia-org-3485	323	36	amygdala	amygdala	NNP
en-wikipedia-org-3485	323	37	,	,	,
en-wikipedia-org-3485	323	38	and	and	CC
en-wikipedia-org-3485	323	39	thalamus	thalamus	NNP
en-wikipedia-org-3485	323	40	(	(	-LRB-
en-wikipedia-org-3485	323	41	Swanson	Swanson	NNP
en-wikipedia-org-3485	323	42	,	,	,
en-wikipedia-org-3485	323	43	1982	1982	CD
en-wikipedia-org-3485	323	44	;	;	:
en-wikipedia-org-3485	323	45	Phillipson	Phillipson	NNP
en-wikipedia-org-3485	323	46	and	and	CC
en-wikipedia-org-3485	323	47	Griffiths	Griffiths	NNP
en-wikipedia-org-3485	323	48	,	,	,
en-wikipedia-org-3485	323	49	1985	1985	CD
en-wikipedia-org-3485	323	50	;	;	:
en-wikipedia-org-3485	323	51	Finch	Finch	NNP
en-wikipedia-org-3485	323	52	,	,	,
en-wikipedia-org-3485	323	53	1996	1996	CD
en-wikipedia-org-3485	323	54	;	;	:
en-wikipedia-org-3485	323	55	Groenewegen	Groenewegen	NNP
en-wikipedia-org-3485	323	56	et	et	NNP
en-wikipedia-org-3485	323	57	al	al	NNP
en-wikipedia-org-3485	323	58	.	.	NNP
en-wikipedia-org-3485	323	59	,	,	,
en-wikipedia-org-3485	323	60	1999	1999	CD
en-wikipedia-org-3485	323	61	;	;	:
en-wikipedia-org-3485	323	62	Britt	Britt	NNP
en-wikipedia-org-3485	323	63	et	et	NNP
en-wikipedia-org-3485	323	64	al	al	NNP
en-wikipedia-org-3485	323	65	.	.	NNP
en-wikipedia-org-3485	323	66	,	,	,
en-wikipedia-org-3485	323	67	2012	2012	CD
en-wikipedia-org-3485	323	68	)	)	-RRB-
en-wikipedia-org-3485	323	69	.	.	.
en-wikipedia-org-3485	324	1	These	these	DT
en-wikipedia-org-3485	324	2	glutamatergic	glutamatergic	JJ
en-wikipedia-org-3485	324	3	inputs	input	NNS
en-wikipedia-org-3485	324	4	make	make	VBP
en-wikipedia-org-3485	324	5	contact	contact	NN
en-wikipedia-org-3485	324	6	on	on	IN
en-wikipedia-org-3485	324	7	the	the	DT
en-wikipedia-org-3485	324	8	heads	head	NNS
en-wikipedia-org-3485	324	9	of	of	IN
en-wikipedia-org-3485	324	10	dendritic	dendritic	JJ
en-wikipedia-org-3485	324	11	spines	spine	NNS
en-wikipedia-org-3485	324	12	of	of	IN
en-wikipedia-org-3485	324	13	the	the	DT
en-wikipedia-org-3485	324	14	striatal	striatal	JJ
en-wikipedia-org-3485	324	15	GABAergic	GABAergic	NNP
en-wikipedia-org-3485	324	16	medium	medium	NNP
en-wikipedia-org-3485	324	17	spiny	spiny	NNP
en-wikipedia-org-3485	324	18	projection	projection	NN
en-wikipedia-org-3485	324	19	neurons	neuron	NNS
en-wikipedia-org-3485	324	20	(	(	-LRB-
en-wikipedia-org-3485	324	21	MSNs	msn	NNS
en-wikipedia-org-3485	324	22	)	)	-RRB-
en-wikipedia-org-3485	324	23	whereas	whereas	IN
en-wikipedia-org-3485	324	24	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	324	25	inputs	input	NNS
en-wikipedia-org-3485	324	26	synapse	synapse	VBD
en-wikipedia-org-3485	324	27	onto	onto	IN
en-wikipedia-org-3485	324	28	the	the	DT
en-wikipedia-org-3485	324	29	spine	spine	NN
en-wikipedia-org-3485	324	30	neck	neck	NN
en-wikipedia-org-3485	324	31	,	,	,
en-wikipedia-org-3485	324	32	allowing	allow	VBG
en-wikipedia-org-3485	324	33	for	for	IN
en-wikipedia-org-3485	324	34	an	an	DT
en-wikipedia-org-3485	324	35	important	important	JJ
en-wikipedia-org-3485	324	36	and	and	CC
en-wikipedia-org-3485	324	37	complex	complex	JJ
en-wikipedia-org-3485	324	38	interaction	interaction	NN
en-wikipedia-org-3485	324	39	between	between	IN
en-wikipedia-org-3485	324	40	these	these	DT
en-wikipedia-org-3485	324	41	two	two	CD
en-wikipedia-org-3485	324	42	inputs	input	NNS
en-wikipedia-org-3485	324	43	in	in	IN
en-wikipedia-org-3485	324	44	modulation	modulation	NN
en-wikipedia-org-3485	324	45	of	of	IN
en-wikipedia-org-3485	324	46	MSN	MSN	NNP
en-wikipedia-org-3485	324	47	activity	activity	NN
en-wikipedia-org-3485	324	48	 	  	_SP
en-wikipedia-org-3485	324	49	...	...	:
en-wikipedia-org-3485	325	1	It	-PRON-	PRP
en-wikipedia-org-3485	325	2	should	should	MD
en-wikipedia-org-3485	325	3	also	also	RB
en-wikipedia-org-3485	325	4	be	be	VB
en-wikipedia-org-3485	325	5	noted	note	VBN
en-wikipedia-org-3485	325	6	that	that	IN
en-wikipedia-org-3485	325	7	there	there	EX
en-wikipedia-org-3485	325	8	is	be	VBZ
en-wikipedia-org-3485	325	9	a	a	DT
en-wikipedia-org-3485	325	10	small	small	JJ
en-wikipedia-org-3485	325	11	population	population	NN
en-wikipedia-org-3485	325	12	of	of	IN
en-wikipedia-org-3485	325	13	neurons	neuron	NNS
en-wikipedia-org-3485	325	14	in	in	IN
en-wikipedia-org-3485	325	15	the	the	DT
en-wikipedia-org-3485	325	16	[	[	-LRB-
en-wikipedia-org-3485	325	17	nucleus	nucleus	NNP
en-wikipedia-org-3485	325	18	accumbens	accumbens	NNPS
en-wikipedia-org-3485	325	19	]	]	-RRB-
en-wikipedia-org-3485	325	20	NAc	NAc	NNS
en-wikipedia-org-3485	325	21	that	that	WDT
en-wikipedia-org-3485	325	22	coexpress	coexpress	VBP
en-wikipedia-org-3485	325	23	both	both	CC
en-wikipedia-org-3485	325	24	D1	D1	NNP
en-wikipedia-org-3485	325	25	and	and	CC
en-wikipedia-org-3485	325	26	D2	D2	NNP
en-wikipedia-org-3485	325	27	receptors	receptor	NNS
en-wikipedia-org-3485	325	28	,	,	,
en-wikipedia-org-3485	325	29	though	though	IN
en-wikipedia-org-3485	325	30	this	this	DT
en-wikipedia-org-3485	325	31	is	be	VBZ
en-wikipedia-org-3485	325	32	largely	largely	RB
en-wikipedia-org-3485	325	33	restricted	restrict	VBN
en-wikipedia-org-3485	325	34	to	to	IN
en-wikipedia-org-3485	325	35	the	the	DT
en-wikipedia-org-3485	325	36	NAc	NAc	NNS
en-wikipedia-org-3485	325	37	shell	shell	NN
en-wikipedia-org-3485	325	38	(	(	-LRB-
en-wikipedia-org-3485	325	39	Bertran-	Bertran-	NNP
en-wikipedia-org-3485	325	40	Gonzalez	Gonzalez	NNP
en-wikipedia-org-3485	325	41	et	et	NNP
en-wikipedia-org-3485	325	42	al	al	NNP
en-wikipedia-org-3485	325	43	.	.	NNP
en-wikipedia-org-3485	325	44	,	,	,
en-wikipedia-org-3485	325	45	2008	2008	CD
en-wikipedia-org-3485	325	46	)	)	-RRB-
en-wikipedia-org-3485	325	47	.	.	.
en-wikipedia-org-3485	326	1	...	...	NFP
en-wikipedia-org-3485	326	2	Neurons	neuron	NNS
en-wikipedia-org-3485	326	3	in	in	IN
en-wikipedia-org-3485	326	4	the	the	DT
en-wikipedia-org-3485	326	5	NAc	NAc	NNS
en-wikipedia-org-3485	326	6	core	core	NN
en-wikipedia-org-3485	326	7	and	and	CC
en-wikipedia-org-3485	326	8	NAc	NAc	NNP
en-wikipedia-org-3485	326	9	shell	shell	NN
en-wikipedia-org-3485	326	10	subdivisions	subdivision	NNS
en-wikipedia-org-3485	326	11	also	also	RB
en-wikipedia-org-3485	326	12	differ	differ	VBP
en-wikipedia-org-3485	326	13	functionally	functionally	RB
en-wikipedia-org-3485	326	14	.	.	.
en-wikipedia-org-3485	327	1	The	the	DT
en-wikipedia-org-3485	327	2	NAc	NAc	NNP
en-wikipedia-org-3485	327	3	core	core	NN
en-wikipedia-org-3485	327	4	is	be	VBZ
en-wikipedia-org-3485	327	5	involved	involve	VBN
en-wikipedia-org-3485	327	6	in	in	IN
en-wikipedia-org-3485	327	7	the	the	DT
en-wikipedia-org-3485	327	8	processing	processing	NN
en-wikipedia-org-3485	327	9	of	of	IN
en-wikipedia-org-3485	327	10	conditioned	condition	VBN
en-wikipedia-org-3485	327	11	stimuli	stimulus	NNS
en-wikipedia-org-3485	327	12	whereas	whereas	IN
en-wikipedia-org-3485	327	13	the	the	DT
en-wikipedia-org-3485	327	14	NAc	NAc	NNP
en-wikipedia-org-3485	327	15	shell	shell	NN
en-wikipedia-org-3485	327	16	is	be	VBZ
en-wikipedia-org-3485	327	17	more	more	RBR
en-wikipedia-org-3485	327	18	important	important	JJ
en-wikipedia-org-3485	327	19	in	in	IN
en-wikipedia-org-3485	327	20	the	the	DT
en-wikipedia-org-3485	327	21	processing	processing	NN
en-wikipedia-org-3485	327	22	of	of	IN
en-wikipedia-org-3485	327	23	unconditioned	unconditioned	JJ
en-wikipedia-org-3485	327	24	stimuli	stimulus	NNS
en-wikipedia-org-3485	327	25	;	;	:
en-wikipedia-org-3485	327	26	Classically	classically	RB
en-wikipedia-org-3485	327	27	,	,	,
en-wikipedia-org-3485	327	28	these	these	DT
en-wikipedia-org-3485	327	29	two	two	CD
en-wikipedia-org-3485	327	30	striatal	striatal	JJ
en-wikipedia-org-3485	327	31	MSN	MSN	NNP
en-wikipedia-org-3485	327	32	populations	population	NNS
en-wikipedia-org-3485	327	33	are	be	VBP
en-wikipedia-org-3485	327	34	thought	think	VBN
en-wikipedia-org-3485	327	35	to	to	TO
en-wikipedia-org-3485	327	36	have	have	VB
en-wikipedia-org-3485	327	37	opposing	oppose	VBG
en-wikipedia-org-3485	327	38	effects	effect	NNS
en-wikipedia-org-3485	327	39	on	on	IN
en-wikipedia-org-3485	327	40	basal	basal	NNP
en-wikipedia-org-3485	327	41	ganglia	ganglia	NNP
en-wikipedia-org-3485	327	42	output	output	NN
en-wikipedia-org-3485	327	43	.	.	.
en-wikipedia-org-3485	328	1	Activation	activation	NN
en-wikipedia-org-3485	328	2	of	of	IN
en-wikipedia-org-3485	328	3	the	the	DT
en-wikipedia-org-3485	328	4	dMSNs	dmsns	NN
en-wikipedia-org-3485	328	5	causes	cause	VBZ
en-wikipedia-org-3485	328	6	a	a	DT
en-wikipedia-org-3485	328	7	net	net	JJ
en-wikipedia-org-3485	328	8	excitation	excitation	NN
en-wikipedia-org-3485	328	9	of	of	IN
en-wikipedia-org-3485	328	10	the	the	DT
en-wikipedia-org-3485	328	11	thalamus	thalamus	NN
en-wikipedia-org-3485	328	12	resulting	result	VBG
en-wikipedia-org-3485	328	13	in	in	IN
en-wikipedia-org-3485	328	14	a	a	DT
en-wikipedia-org-3485	328	15	positive	positive	JJ
en-wikipedia-org-3485	328	16	cortical	cortical	JJ
en-wikipedia-org-3485	328	17	feedback	feedback	NN
en-wikipedia-org-3485	328	18	loop	loop	NN
en-wikipedia-org-3485	328	19	;	;	:
en-wikipedia-org-3485	328	20	thereby	thereby	RB
en-wikipedia-org-3485	328	21	acting	act	VBG
en-wikipedia-org-3485	328	22	as	as	IN
en-wikipedia-org-3485	328	23	a	a	DT
en-wikipedia-org-3485	328	24	'	'	``
en-wikipedia-org-3485	328	25	go	go	NN
en-wikipedia-org-3485	328	26	’	'	''
en-wikipedia-org-3485	328	27	signal	signal	NN
en-wikipedia-org-3485	328	28	to	to	TO
en-wikipedia-org-3485	328	29	initiate	initiate	VB
en-wikipedia-org-3485	328	30	behavior	behavior	NN
en-wikipedia-org-3485	328	31	.	.	.
en-wikipedia-org-3485	329	1	Activation	activation	NN
en-wikipedia-org-3485	329	2	of	of	IN
en-wikipedia-org-3485	329	3	the	the	DT
en-wikipedia-org-3485	329	4	iMSNs	imsns	NN
en-wikipedia-org-3485	329	5	,	,	,
en-wikipedia-org-3485	329	6	however	however	RB
en-wikipedia-org-3485	329	7	,	,	,
en-wikipedia-org-3485	329	8	causes	cause	VBZ
en-wikipedia-org-3485	329	9	a	a	DT
en-wikipedia-org-3485	329	10	net	net	JJ
en-wikipedia-org-3485	329	11	inhibition	inhibition	NN
en-wikipedia-org-3485	329	12	of	of	IN
en-wikipedia-org-3485	329	13	thalamic	thalamic	JJ
en-wikipedia-org-3485	329	14	activity	activity	NN
en-wikipedia-org-3485	329	15	resulting	result	VBG
en-wikipedia-org-3485	329	16	in	in	IN
en-wikipedia-org-3485	329	17	a	a	DT
en-wikipedia-org-3485	329	18	negative	negative	JJ
en-wikipedia-org-3485	329	19	cortical	cortical	JJ
en-wikipedia-org-3485	329	20	feedback	feedback	NN
en-wikipedia-org-3485	329	21	loop	loop	NN
en-wikipedia-org-3485	329	22	and	and	CC
en-wikipedia-org-3485	329	23	therefore	therefore	RB
en-wikipedia-org-3485	329	24	serves	serve	VBZ
en-wikipedia-org-3485	329	25	as	as	IN
en-wikipedia-org-3485	329	26	a	a	DT
en-wikipedia-org-3485	329	27	'	'	``
en-wikipedia-org-3485	329	28	brake	brake	NN
en-wikipedia-org-3485	329	29	’	'	''
en-wikipedia-org-3485	329	30	to	to	TO
en-wikipedia-org-3485	329	31	inhibit	inhibit	VB
en-wikipedia-org-3485	329	32	behavior	behavior	NN
en-wikipedia-org-3485	329	33	 	  	_SP
en-wikipedia-org-3485	329	34	...	...	NFP
en-wikipedia-org-3485	329	35	there	there	EX
en-wikipedia-org-3485	329	36	is	be	VBZ
en-wikipedia-org-3485	329	37	also	also	RB
en-wikipedia-org-3485	329	38	mounting	mount	VBG
en-wikipedia-org-3485	329	39	evidence	evidence	NN
en-wikipedia-org-3485	329	40	that	that	IN
en-wikipedia-org-3485	329	41	iMSNs	imsns	NN
en-wikipedia-org-3485	329	42	play	play	VBP
en-wikipedia-org-3485	329	43	a	a	DT
en-wikipedia-org-3485	329	44	role	role	NN
en-wikipedia-org-3485	329	45	in	in	IN
en-wikipedia-org-3485	329	46	motivation	motivation	NN
en-wikipedia-org-3485	329	47	and	and	CC
en-wikipedia-org-3485	329	48	addiction	addiction	NN
en-wikipedia-org-3485	329	49	(	(	-LRB-
en-wikipedia-org-3485	329	50	Lobo	Lobo	NNP
en-wikipedia-org-3485	329	51	and	and	CC
en-wikipedia-org-3485	329	52	Nestler	Nestler	NNP
en-wikipedia-org-3485	329	53	,	,	,
en-wikipedia-org-3485	329	54	2011	2011	CD
en-wikipedia-org-3485	329	55	;	;	:
en-wikipedia-org-3485	329	56	Grueter	Grueter	NNP
en-wikipedia-org-3485	329	57	et	et	NNP
en-wikipedia-org-3485	329	58	al	al	NNP
en-wikipedia-org-3485	329	59	.	.	NNP
en-wikipedia-org-3485	329	60	,	,	,
en-wikipedia-org-3485	329	61	2013	2013	CD
en-wikipedia-org-3485	329	62	)	)	-RRB-
en-wikipedia-org-3485	329	63	.	.	.
en-wikipedia-org-3485	330	1	For	for	IN
en-wikipedia-org-3485	330	2	example	example	NN
en-wikipedia-org-3485	330	3	,	,	,
en-wikipedia-org-3485	330	4	optogenetic	optogenetic	JJ
en-wikipedia-org-3485	330	5	activation	activation	NN
en-wikipedia-org-3485	330	6	of	of	IN
en-wikipedia-org-3485	330	7	NAc	NAc	NNP
en-wikipedia-org-3485	330	8	core	core	NN
en-wikipedia-org-3485	330	9	and	and	CC
en-wikipedia-org-3485	330	10	shell	shell	NNP
en-wikipedia-org-3485	330	11	iMSNs	iMSNs	NNP
en-wikipedia-org-3485	330	12	suppressed	suppress	VBD
en-wikipedia-org-3485	330	13	the	the	DT
en-wikipedia-org-3485	330	14	development	development	NN
en-wikipedia-org-3485	330	15	of	of	IN
en-wikipedia-org-3485	330	16	a	a	DT
en-wikipedia-org-3485	330	17	cocaine	cocaine	NN
en-wikipedia-org-3485	330	18	CPP	cpp	NN
en-wikipedia-org-3485	330	19	whereas	whereas	IN
en-wikipedia-org-3485	330	20	selective	selective	JJ
en-wikipedia-org-3485	330	21	ablation	ablation	NN
en-wikipedia-org-3485	330	22	of	of	IN
en-wikipedia-org-3485	330	23	NAc	NAc	NNS
en-wikipedia-org-3485	330	24	core	core	NN
en-wikipedia-org-3485	330	25	and	and	CC
en-wikipedia-org-3485	330	26	shell	shell	NNP
en-wikipedia-org-3485	330	27	iMSNs	iMSNs	NNP
en-wikipedia-org-3485	330	28	 	  	_SP
en-wikipedia-org-3485	330	29	...	...	:
en-wikipedia-org-3485	330	30	enhanced	enhance	VBD
en-wikipedia-org-3485	330	31	the	the	DT
en-wikipedia-org-3485	330	32	development	development	NN
en-wikipedia-org-3485	330	33	and	and	CC
en-wikipedia-org-3485	330	34	the	the	DT
en-wikipedia-org-3485	330	35	persistence	persistence	NN
en-wikipedia-org-3485	330	36	of	of	IN
en-wikipedia-org-3485	330	37	an	an	DT
en-wikipedia-org-3485	330	38	amphetamine	amphetamine	NN
en-wikipedia-org-3485	330	39	CPP	CPP	NNP
en-wikipedia-org-3485	330	40	(	(	-LRB-
en-wikipedia-org-3485	330	41	Durieux	Durieux	NNP
en-wikipedia-org-3485	330	42	et	et	FW
en-wikipedia-org-3485	330	43	al	al	NNP
en-wikipedia-org-3485	330	44	.	.	NNP
en-wikipedia-org-3485	330	45	,	,	,
en-wikipedia-org-3485	330	46	2009	2009	CD
en-wikipedia-org-3485	330	47	;	;	:
en-wikipedia-org-3485	330	48	Lobo	Lobo	NNP
en-wikipedia-org-3485	330	49	et	et	FW
en-wikipedia-org-3485	330	50	al	al	NNP
en-wikipedia-org-3485	330	51	.	.	NNP
en-wikipedia-org-3485	330	52	,	,	,
en-wikipedia-org-3485	330	53	2010	2010	CD
en-wikipedia-org-3485	330	54	)	)	-RRB-
en-wikipedia-org-3485	330	55	.	.	.
en-wikipedia-org-3485	331	1	These	these	DT
en-wikipedia-org-3485	331	2	findings	finding	NNS
en-wikipedia-org-3485	331	3	suggest	suggest	VBP
en-wikipedia-org-3485	331	4	that	that	IN
en-wikipedia-org-3485	331	5	iMSNs	iMSNs	NNP
en-wikipedia-org-3485	331	6	can	can	MD
en-wikipedia-org-3485	331	7	bidirectionally	bidirectionally	RB
en-wikipedia-org-3485	331	8	modulate	modulate	VB
en-wikipedia-org-3485	331	9	drug	drug	NN
en-wikipedia-org-3485	331	10	reward	reward	NN
en-wikipedia-org-3485	331	11	.	.	.
en-wikipedia-org-3485	332	1	...	...	NFP
en-wikipedia-org-3485	333	1	Together	together	RB
en-wikipedia-org-3485	333	2	these	these	DT
en-wikipedia-org-3485	333	3	data	datum	NNS
en-wikipedia-org-3485	333	4	suggest	suggest	VBP
en-wikipedia-org-3485	333	5	that	that	IN
en-wikipedia-org-3485	333	6	iMSNs	iMSNs	NNP
en-wikipedia-org-3485	333	7	normally	normally	RB
en-wikipedia-org-3485	333	8	act	act	VBP
en-wikipedia-org-3485	333	9	to	to	TO
en-wikipedia-org-3485	333	10	restrain	restrain	VB
en-wikipedia-org-3485	333	11	drug	drug	NN
en-wikipedia-org-3485	333	12	-	-	HYPH
en-wikipedia-org-3485	333	13	taking	take	VBG
en-wikipedia-org-3485	333	14	behavior	behavior	NN
en-wikipedia-org-3485	333	15	and	and	CC
en-wikipedia-org-3485	333	16	recruitment	recruitment	NN
en-wikipedia-org-3485	333	17	of	of	IN
en-wikipedia-org-3485	333	18	these	these	DT
en-wikipedia-org-3485	333	19	neurons	neuron	NNS
en-wikipedia-org-3485	333	20	may	may	MD
en-wikipedia-org-3485	333	21	in	in	IN
en-wikipedia-org-3485	333	22	fact	fact	NN
en-wikipedia-org-3485	333	23	be	be	VB
en-wikipedia-org-3485	333	24	protective	protective	JJ
en-wikipedia-org-3485	333	25	against	against	IN
en-wikipedia-org-3485	333	26	the	the	DT
en-wikipedia-org-3485	333	27	development	development	NN
en-wikipedia-org-3485	333	28	of	of	IN
en-wikipedia-org-3485	333	29	compulsive	compulsive	JJ
en-wikipedia-org-3485	333	30	drug	drug	NN
en-wikipedia-org-3485	333	31	use	use	NN
en-wikipedia-org-3485	333	32	.	.	.
en-wikipedia-org-3485	334	1	^	^	NNP
en-wikipedia-org-3485	334	2	Taylor	Taylor	NNP
en-wikipedia-org-3485	334	3	SB	SB	NNP
en-wikipedia-org-3485	334	4	,	,	,
en-wikipedia-org-3485	334	5	Lewis	Lewis	NNP
en-wikipedia-org-3485	334	6	CR	CR	NNP
en-wikipedia-org-3485	334	7	,	,	,
en-wikipedia-org-3485	334	8	Olive	Olive	NNP
en-wikipedia-org-3485	334	9	MF	MF	NNP
en-wikipedia-org-3485	334	10	(	(	-LRB-
en-wikipedia-org-3485	334	11	2013	2013	CD
en-wikipedia-org-3485	334	12	)	)	-RRB-
en-wikipedia-org-3485	334	13	.	.	.
en-wikipedia-org-3485	335	1	"	"	``
en-wikipedia-org-3485	335	2	The	the	DT
en-wikipedia-org-3485	335	3	neurocircuitry	neurocircuitry	NN
en-wikipedia-org-3485	335	4	of	of	IN
en-wikipedia-org-3485	335	5	illicit	illicit	JJ
en-wikipedia-org-3485	335	6	psychostimulant	psychostimulant	JJ
en-wikipedia-org-3485	335	7	addiction	addiction	NN
en-wikipedia-org-3485	335	8	:	:	:
en-wikipedia-org-3485	335	9	acute	acute	JJ
en-wikipedia-org-3485	335	10	and	and	CC
en-wikipedia-org-3485	335	11	chronic	chronic	JJ
en-wikipedia-org-3485	335	12	effects	effect	NNS
en-wikipedia-org-3485	335	13	in	in	IN
en-wikipedia-org-3485	335	14	humans	human	NNS
en-wikipedia-org-3485	335	15	"	"	''
en-wikipedia-org-3485	335	16	.	.	.
en-wikipedia-org-3485	336	1	Subst	Subst	NNP
en-wikipedia-org-3485	336	2	Abuse	abuse	NN
en-wikipedia-org-3485	336	3	Rehabil	Rehabil	NNP
en-wikipedia-org-3485	336	4	.	.	.
en-wikipedia-org-3485	337	1	4	4	LS
en-wikipedia-org-3485	337	2	:	:	SYM
en-wikipedia-org-3485	337	3	29–43	29–43	CD
en-wikipedia-org-3485	337	4	.	.	.
en-wikipedia-org-3485	338	1	doi:10.2147	doi:10.2147	NNP
en-wikipedia-org-3485	338	2	/	/	SYM
en-wikipedia-org-3485	338	3	SAR.S39684	SAR.S39684	NNP
en-wikipedia-org-3485	338	4	.	.	.
en-wikipedia-org-3485	339	1	PMC	PMC	NNP
en-wikipedia-org-3485	339	2	 	  	_SP
en-wikipedia-org-3485	339	3	3931688	3931688	CD
en-wikipedia-org-3485	339	4	.	.	.
en-wikipedia-org-3485	340	1	PMID	PMID	NNP
en-wikipedia-org-3485	340	2	 	  	_SP
en-wikipedia-org-3485	340	3	24648786	24648786	CD
en-wikipedia-org-3485	340	4	.	.	.
en-wikipedia-org-3485	341	1	Regions	region	NNS
en-wikipedia-org-3485	341	2	of	of	IN
en-wikipedia-org-3485	341	3	the	the	DT
en-wikipedia-org-3485	341	4	basal	basal	NNP
en-wikipedia-org-3485	341	5	ganglia	ganglia	NNP
en-wikipedia-org-3485	341	6	,	,	,
en-wikipedia-org-3485	341	7	which	which	WDT
en-wikipedia-org-3485	341	8	include	include	VBP
en-wikipedia-org-3485	341	9	the	the	DT
en-wikipedia-org-3485	341	10	dorsal	dorsal	NN
en-wikipedia-org-3485	341	11	and	and	CC
en-wikipedia-org-3485	341	12	ventral	ventral	JJ
en-wikipedia-org-3485	341	13	striatum	striatum	NN
en-wikipedia-org-3485	341	14	,	,	,
en-wikipedia-org-3485	341	15	internal	internal	JJ
en-wikipedia-org-3485	341	16	and	and	CC
en-wikipedia-org-3485	341	17	external	external	JJ
en-wikipedia-org-3485	341	18	segments	segment	NNS
en-wikipedia-org-3485	341	19	of	of	IN
en-wikipedia-org-3485	341	20	the	the	DT
en-wikipedia-org-3485	341	21	globus	globus	NNP
en-wikipedia-org-3485	341	22	pallidus	pallidus	NNP
en-wikipedia-org-3485	341	23	,	,	,
en-wikipedia-org-3485	341	24	subthalamic	subthalamic	JJ
en-wikipedia-org-3485	341	25	nucleus	nucleus	NN
en-wikipedia-org-3485	341	26	,	,	,
en-wikipedia-org-3485	341	27	and	and	CC
en-wikipedia-org-3485	341	28	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	341	29	cell	cell	NN
en-wikipedia-org-3485	341	30	bodies	body	NNS
en-wikipedia-org-3485	341	31	in	in	IN
en-wikipedia-org-3485	341	32	the	the	DT
en-wikipedia-org-3485	341	33	substantia	substantia	NN
en-wikipedia-org-3485	341	34	nigra	nigra	NNP
en-wikipedia-org-3485	341	35	,	,	,
en-wikipedia-org-3485	341	36	are	be	VBP
en-wikipedia-org-3485	341	37	highly	highly	RB
en-wikipedia-org-3485	341	38	implicated	implicated	JJ
en-wikipedia-org-3485	341	39	not	not	RB
en-wikipedia-org-3485	341	40	only	only	RB
en-wikipedia-org-3485	341	41	in	in	IN
en-wikipedia-org-3485	341	42	fine	fine	JJ
en-wikipedia-org-3485	341	43	motor	motor	NN
en-wikipedia-org-3485	341	44	control	control	NN
en-wikipedia-org-3485	341	45	but	but	CC
en-wikipedia-org-3485	341	46	also	also	RB
en-wikipedia-org-3485	341	47	in	in	IN
en-wikipedia-org-3485	341	48	[	[	-LRB-
en-wikipedia-org-3485	341	49	prefrontal	prefrontal	JJ
en-wikipedia-org-3485	341	50	cortex	cortex	NN
en-wikipedia-org-3485	341	51	]	]	-RRB-
en-wikipedia-org-3485	341	52	PFC	PFC	NNP
en-wikipedia-org-3485	341	53	function.43	function.43	NNP
en-wikipedia-org-3485	341	54	Of	of	IN
en-wikipedia-org-3485	341	55	these	these	DT
en-wikipedia-org-3485	341	56	regions	region	NNS
en-wikipedia-org-3485	341	57	,	,	,
en-wikipedia-org-3485	341	58	the	the	DT
en-wikipedia-org-3485	341	59	[	[	-LRB-
en-wikipedia-org-3485	341	60	nucleus	nucleus	NNP
en-wikipedia-org-3485	341	61	accumbens	accumbens	NNPS
en-wikipedia-org-3485	341	62	]	]	-RRB-
en-wikipedia-org-3485	341	63	NAc	NAc	NNS
en-wikipedia-org-3485	341	64	(	(	-LRB-
en-wikipedia-org-3485	341	65	described	describe	VBN
en-wikipedia-org-3485	341	66	above	above	RB
en-wikipedia-org-3485	341	67	)	)	-RRB-
en-wikipedia-org-3485	341	68	and	and	CC
en-wikipedia-org-3485	341	69	the	the	DT
en-wikipedia-org-3485	341	70	[	[	-LRB-
en-wikipedia-org-3485	341	71	dorsal	dorsal	NN
en-wikipedia-org-3485	341	72	striatum	striatum	NN
en-wikipedia-org-3485	341	73	]	]	-RRB-
en-wikipedia-org-3485	341	74	DS	DS	NNP
en-wikipedia-org-3485	341	75	(	(	-LRB-
en-wikipedia-org-3485	341	76	described	describe	VBN
en-wikipedia-org-3485	341	77	below	below	RB
en-wikipedia-org-3485	341	78	)	)	-RRB-
en-wikipedia-org-3485	341	79	are	be	VBP
en-wikipedia-org-3485	341	80	most	most	RBS
en-wikipedia-org-3485	341	81	frequently	frequently	RB
en-wikipedia-org-3485	341	82	examined	examine	VBN
en-wikipedia-org-3485	341	83	with	with	IN
en-wikipedia-org-3485	341	84	respect	respect	NN
en-wikipedia-org-3485	341	85	to	to	IN
en-wikipedia-org-3485	341	86	addiction	addiction	NN
en-wikipedia-org-3485	341	87	.	.	.
en-wikipedia-org-3485	342	1	Thus	thus	RB
en-wikipedia-org-3485	342	2	,	,	,
en-wikipedia-org-3485	342	3	only	only	RB
en-wikipedia-org-3485	342	4	a	a	DT
en-wikipedia-org-3485	342	5	brief	brief	JJ
en-wikipedia-org-3485	342	6	description	description	NN
en-wikipedia-org-3485	342	7	of	of	IN
en-wikipedia-org-3485	342	8	the	the	DT
en-wikipedia-org-3485	342	9	modulatory	modulatory	JJ
en-wikipedia-org-3485	342	10	role	role	NN
en-wikipedia-org-3485	342	11	of	of	IN
en-wikipedia-org-3485	342	12	the	the	DT
en-wikipedia-org-3485	342	13	basal	basal	NNP
en-wikipedia-org-3485	342	14	ganglia	ganglia	NNP
en-wikipedia-org-3485	342	15	in	in	IN
en-wikipedia-org-3485	342	16	addiction	addiction	NN
en-wikipedia-org-3485	342	17	-	-	HYPH
en-wikipedia-org-3485	342	18	relevant	relevant	JJ
en-wikipedia-org-3485	342	19	circuits	circuit	NNS
en-wikipedia-org-3485	342	20	will	will	MD
en-wikipedia-org-3485	342	21	be	be	VB
en-wikipedia-org-3485	342	22	mentioned	mention	VBN
en-wikipedia-org-3485	342	23	here	here	RB
en-wikipedia-org-3485	342	24	.	.	.
en-wikipedia-org-3485	343	1	The	the	DT
en-wikipedia-org-3485	343	2	overall	overall	JJ
en-wikipedia-org-3485	343	3	output	output	NN
en-wikipedia-org-3485	343	4	of	of	IN
en-wikipedia-org-3485	343	5	the	the	DT
en-wikipedia-org-3485	343	6	basal	basal	NN
en-wikipedia-org-3485	343	7	ganglia	ganglia	NNP
en-wikipedia-org-3485	343	8	is	be	VBZ
en-wikipedia-org-3485	343	9	predominantly	predominantly	RB
en-wikipedia-org-3485	343	10	via	via	IN
en-wikipedia-org-3485	343	11	the	the	DT
en-wikipedia-org-3485	343	12	thalamus	thalamus	NN
en-wikipedia-org-3485	343	13	,	,	,
en-wikipedia-org-3485	343	14	which	which	WDT
en-wikipedia-org-3485	343	15	then	then	RB
en-wikipedia-org-3485	343	16	projects	project	VBZ
en-wikipedia-org-3485	343	17	back	back	RB
en-wikipedia-org-3485	343	18	to	to	IN
en-wikipedia-org-3485	343	19	the	the	DT
en-wikipedia-org-3485	343	20	PFC	PFC	NNP
en-wikipedia-org-3485	343	21	to	to	TO
en-wikipedia-org-3485	343	22	form	form	VB
en-wikipedia-org-3485	343	23	cortico	cortico	NN
en-wikipedia-org-3485	343	24	-	-	HYPH
en-wikipedia-org-3485	343	25	striatal	striatal	JJ
en-wikipedia-org-3485	343	26	-	-	HYPH
en-wikipedia-org-3485	343	27	thalamo	thalamo	NN
en-wikipedia-org-3485	343	28	-	-	HYPH
en-wikipedia-org-3485	343	29	cortical	cortical	JJ
en-wikipedia-org-3485	343	30	(	(	-LRB-
en-wikipedia-org-3485	343	31	CSTC	CSTC	NNP
en-wikipedia-org-3485	343	32	)	)	-RRB-
en-wikipedia-org-3485	343	33	loops	loop	NNS
en-wikipedia-org-3485	343	34	.	.	.
en-wikipedia-org-3485	344	1	Three	three	CD
en-wikipedia-org-3485	344	2	CSTC	CSTC	NNP
en-wikipedia-org-3485	344	3	loops	loop	NNS
en-wikipedia-org-3485	344	4	are	be	VBP
en-wikipedia-org-3485	344	5	proposed	propose	VBN
en-wikipedia-org-3485	344	6	to	to	TO
en-wikipedia-org-3485	344	7	modulate	modulate	VB
en-wikipedia-org-3485	344	8	executive	executive	JJ
en-wikipedia-org-3485	344	9	function	function	NN
en-wikipedia-org-3485	344	10	,	,	,
en-wikipedia-org-3485	344	11	action	action	NN
en-wikipedia-org-3485	344	12	selection	selection	NN
en-wikipedia-org-3485	344	13	,	,	,
en-wikipedia-org-3485	344	14	and	and	CC
en-wikipedia-org-3485	344	15	behavioral	behavioral	JJ
en-wikipedia-org-3485	344	16	inhibition	inhibition	NN
en-wikipedia-org-3485	344	17	.	.	.
en-wikipedia-org-3485	345	1	In	in	IN
en-wikipedia-org-3485	345	2	the	the	DT
en-wikipedia-org-3485	345	3	dorsolateral	dorsolateral	JJ
en-wikipedia-org-3485	345	4	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	345	5	circuit	circuit	NNP
en-wikipedia-org-3485	345	6	,	,	,
en-wikipedia-org-3485	345	7	the	the	DT
en-wikipedia-org-3485	345	8	basal	basal	NN
en-wikipedia-org-3485	345	9	ganglia	ganglia	NNP
en-wikipedia-org-3485	345	10	primarily	primarily	RB
en-wikipedia-org-3485	345	11	modulate	modulate	VBP
en-wikipedia-org-3485	345	12	the	the	DT
en-wikipedia-org-3485	345	13	identification	identification	NN
en-wikipedia-org-3485	345	14	and	and	CC
en-wikipedia-org-3485	345	15	selection	selection	NN
en-wikipedia-org-3485	345	16	of	of	IN
en-wikipedia-org-3485	345	17	goals	goal	NNS
en-wikipedia-org-3485	345	18	,	,	,
en-wikipedia-org-3485	345	19	including	include	VBG
en-wikipedia-org-3485	345	20	rewards.44	rewards.44	NNP
en-wikipedia-org-3485	345	21	The	the	DT
en-wikipedia-org-3485	345	22	[	[	-LRB-
en-wikipedia-org-3485	345	23	orbitofrontal	orbitofrontal	JJ
en-wikipedia-org-3485	345	24	cortex	cortex	NN
en-wikipedia-org-3485	345	25	]	]	-RRB-
en-wikipedia-org-3485	345	26	OFC	OFC	NNP
en-wikipedia-org-3485	345	27	circuit	circuit	NN
en-wikipedia-org-3485	345	28	modulates	modulate	VBZ
en-wikipedia-org-3485	345	29	decision	decision	NN
en-wikipedia-org-3485	345	30	-	-	HYPH
en-wikipedia-org-3485	345	31	making	making	NN
en-wikipedia-org-3485	345	32	and	and	CC
en-wikipedia-org-3485	345	33	impulsivity	impulsivity	NN
en-wikipedia-org-3485	345	34	,	,	,
en-wikipedia-org-3485	345	35	and	and	CC
en-wikipedia-org-3485	345	36	the	the	DT
en-wikipedia-org-3485	345	37	anterior	anterior	NNP
en-wikipedia-org-3485	345	38	cingulate	cingulate	NNP
en-wikipedia-org-3485	345	39	circuit	circuit	NN
en-wikipedia-org-3485	345	40	modulates	modulate	VBZ
en-wikipedia-org-3485	345	41	the	the	DT
en-wikipedia-org-3485	345	42	assessment	assessment	NN
en-wikipedia-org-3485	345	43	of	of	IN
en-wikipedia-org-3485	345	44	consequences.44	consequences.44	NNP
en-wikipedia-org-3485	345	45	These	these	DT
en-wikipedia-org-3485	345	46	circuits	circuit	NNS
en-wikipedia-org-3485	345	47	are	be	VBP
en-wikipedia-org-3485	345	48	modulated	modulate	VBN
en-wikipedia-org-3485	345	49	by	by	IN
en-wikipedia-org-3485	345	50	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	345	51	inputs	input	NNS
en-wikipedia-org-3485	345	52	from	from	IN
en-wikipedia-org-3485	345	53	the	the	DT
en-wikipedia-org-3485	345	54	[	[	-LRB-
en-wikipedia-org-3485	345	55	ventral	ventral	JJ
en-wikipedia-org-3485	345	56	tegmental	tegmental	JJ
en-wikipedia-org-3485	345	57	area	area	NN
en-wikipedia-org-3485	345	58	]	]	-RRB-
en-wikipedia-org-3485	345	59	VTA	VTA	NNP
en-wikipedia-org-3485	345	60	to	to	TO
en-wikipedia-org-3485	345	61	ultimately	ultimately	RB
en-wikipedia-org-3485	345	62	guide	guide	VB
en-wikipedia-org-3485	345	63	behaviors	behavior	NNS
en-wikipedia-org-3485	345	64	relevant	relevant	JJ
en-wikipedia-org-3485	345	65	to	to	IN
en-wikipedia-org-3485	345	66	addiction	addiction	NN
en-wikipedia-org-3485	345	67	,	,	,
en-wikipedia-org-3485	345	68	including	include	VBG
en-wikipedia-org-3485	345	69	the	the	DT
en-wikipedia-org-3485	345	70	persistence	persistence	NN
en-wikipedia-org-3485	345	71	and	and	CC
en-wikipedia-org-3485	345	72	narrowing	narrowing	NN
en-wikipedia-org-3485	345	73	of	of	IN
en-wikipedia-org-3485	345	74	the	the	DT
en-wikipedia-org-3485	345	75	behavioral	behavioral	JJ
en-wikipedia-org-3485	345	76	repertoire	repertoire	NN
en-wikipedia-org-3485	345	77	toward	toward	IN
en-wikipedia-org-3485	345	78	drug	drug	NN
en-wikipedia-org-3485	345	79	seeking	seeking	NN
en-wikipedia-org-3485	345	80	,	,	,
en-wikipedia-org-3485	345	81	and	and	CC
en-wikipedia-org-3485	345	82	continued	continue	VBN
en-wikipedia-org-3485	345	83	drug	drug	NN
en-wikipedia-org-3485	345	84	use	use	NN
en-wikipedia-org-3485	345	85	despite	despite	IN
en-wikipedia-org-3485	345	86	negative	negative	JJ
en-wikipedia-org-3485	345	87	consequences.43–45	consequences.43–45	NNP
en-wikipedia-org-3485	345	88	^	^	NN
en-wikipedia-org-3485	345	89	Grall	Grall	NNP
en-wikipedia-org-3485	345	90	-	-	HYPH
en-wikipedia-org-3485	345	91	Bronnec	Bronnec	NNP
en-wikipedia-org-3485	345	92	M	M	NNP
en-wikipedia-org-3485	345	93	,	,	,
en-wikipedia-org-3485	345	94	Sauvaget	Sauvaget	NNP
en-wikipedia-org-3485	345	95	A	a	NN
en-wikipedia-org-3485	345	96	(	(	-LRB-
en-wikipedia-org-3485	345	97	2014	2014	CD
en-wikipedia-org-3485	345	98	)	)	-RRB-
en-wikipedia-org-3485	345	99	.	.	.
en-wikipedia-org-3485	346	1	"	"	``
en-wikipedia-org-3485	346	2	The	the	DT
en-wikipedia-org-3485	346	3	use	use	NN
en-wikipedia-org-3485	346	4	of	of	IN
en-wikipedia-org-3485	346	5	repetitive	repetitive	JJ
en-wikipedia-org-3485	346	6	transcranial	transcranial	JJ
en-wikipedia-org-3485	346	7	magnetic	magnetic	JJ
en-wikipedia-org-3485	346	8	stimulation	stimulation	NN
en-wikipedia-org-3485	346	9	for	for	IN
en-wikipedia-org-3485	346	10	modulating	modulate	VBG
en-wikipedia-org-3485	346	11	craving	craving	NN
en-wikipedia-org-3485	346	12	and	and	CC
en-wikipedia-org-3485	346	13	addictive	addictive	JJ
en-wikipedia-org-3485	346	14	behaviours	behaviour	NNS
en-wikipedia-org-3485	346	15	:	:	:
en-wikipedia-org-3485	346	16	a	a	DT
en-wikipedia-org-3485	346	17	critical	critical	JJ
en-wikipedia-org-3485	346	18	literature	literature	NN
en-wikipedia-org-3485	346	19	review	review	NN
en-wikipedia-org-3485	346	20	of	of	IN
en-wikipedia-org-3485	346	21	efficacy	efficacy	NN
en-wikipedia-org-3485	346	22	,	,	,
en-wikipedia-org-3485	346	23	technical	technical	JJ
en-wikipedia-org-3485	346	24	and	and	CC
en-wikipedia-org-3485	346	25	methodological	methodological	JJ
en-wikipedia-org-3485	346	26	considerations	consideration	NNS
en-wikipedia-org-3485	346	27	"	"	''
en-wikipedia-org-3485	346	28	.	.	.
en-wikipedia-org-3485	347	1	Neurosci	Neurosci	NNP
en-wikipedia-org-3485	347	2	.	.	.
en-wikipedia-org-3485	348	1	Biobehav	Biobehav	NNP
en-wikipedia-org-3485	348	2	.	.	.
en-wikipedia-org-3485	349	1	Rev.	Rev.	NNP
en-wikipedia-org-3485	350	1	47	47	CD
en-wikipedia-org-3485	350	2	:	:	:
en-wikipedia-org-3485	350	3	592–613	592–613	CD
en-wikipedia-org-3485	350	4	.	.	.
en-wikipedia-org-3485	351	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	351	2	/	/	SYM
en-wikipedia-org-3485	351	3	j.neubiorev.2014.10.013	j.neubiorev.2014.10.013	NNP
en-wikipedia-org-3485	351	4	.	.	.
en-wikipedia-org-3485	352	1	PMID	PMID	NNP
en-wikipedia-org-3485	352	2	 	  	_SP
en-wikipedia-org-3485	352	3	25454360	25454360	CD
en-wikipedia-org-3485	352	4	.	.	.
en-wikipedia-org-3485	353	1	Studies	study	NNS
en-wikipedia-org-3485	353	2	have	have	VBP
en-wikipedia-org-3485	353	3	shown	show	VBN
en-wikipedia-org-3485	353	4	that	that	IN
en-wikipedia-org-3485	353	5	cravings	craving	NNS
en-wikipedia-org-3485	353	6	are	be	VBP
en-wikipedia-org-3485	353	7	underpinned	underpin	VBN
en-wikipedia-org-3485	353	8	by	by	IN
en-wikipedia-org-3485	353	9	activation	activation	NN
en-wikipedia-org-3485	353	10	of	of	IN
en-wikipedia-org-3485	353	11	the	the	DT
en-wikipedia-org-3485	353	12	reward	reward	NN
en-wikipedia-org-3485	353	13	and	and	CC
en-wikipedia-org-3485	353	14	motivation	motivation	NN
en-wikipedia-org-3485	353	15	circuits	circuit	NNS
en-wikipedia-org-3485	353	16	(	(	-LRB-
en-wikipedia-org-3485	353	17	McBride	McBride	NNP
en-wikipedia-org-3485	353	18	et	et	NNP
en-wikipedia-org-3485	353	19	al	al	NNP
en-wikipedia-org-3485	353	20	.	.	NNP
en-wikipedia-org-3485	353	21	,	,	,
en-wikipedia-org-3485	353	22	2006	2006	CD
en-wikipedia-org-3485	353	23	,	,	,
en-wikipedia-org-3485	353	24	Wang	Wang	NNP
en-wikipedia-org-3485	353	25	et	et	NNP
en-wikipedia-org-3485	353	26	al	al	NNP
en-wikipedia-org-3485	353	27	.	.	NNP
en-wikipedia-org-3485	353	28	,	,	,
en-wikipedia-org-3485	353	29	2007	2007	CD
en-wikipedia-org-3485	353	30	,	,	,
en-wikipedia-org-3485	353	31	Wing	Wing	NNP
en-wikipedia-org-3485	353	32	et	et	NNP
en-wikipedia-org-3485	353	33	al	al	NNP
en-wikipedia-org-3485	353	34	.	.	NNP
en-wikipedia-org-3485	353	35	,	,	,
en-wikipedia-org-3485	353	36	2012	2012	CD
en-wikipedia-org-3485	353	37	,	,	,
en-wikipedia-org-3485	353	38	Goldman	Goldman	NNP
en-wikipedia-org-3485	353	39	et	et	FW
en-wikipedia-org-3485	353	40	al	al	NNP
en-wikipedia-org-3485	353	41	.	.	NNP
en-wikipedia-org-3485	353	42	,	,	,
en-wikipedia-org-3485	353	43	2013	2013	CD
en-wikipedia-org-3485	353	44	,	,	,
en-wikipedia-org-3485	353	45	Jansen	Jansen	NNP
en-wikipedia-org-3485	353	46	et	et	NNP
en-wikipedia-org-3485	353	47	al	al	NNP
en-wikipedia-org-3485	353	48	.	.	NNP
en-wikipedia-org-3485	353	49	,	,	,
en-wikipedia-org-3485	353	50	2013	2013	CD
en-wikipedia-org-3485	353	51	and	and	CC
en-wikipedia-org-3485	353	52	Volkow	Volkow	NNP
en-wikipedia-org-3485	353	53	et	et	NNP
en-wikipedia-org-3485	353	54	al	al	NNP
en-wikipedia-org-3485	353	55	.	.	NNP
en-wikipedia-org-3485	353	56	,	,	,
en-wikipedia-org-3485	353	57	2013	2013	CD
en-wikipedia-org-3485	353	58	)	)	-RRB-
en-wikipedia-org-3485	353	59	.	.	.
en-wikipedia-org-3485	354	1	According	accord	VBG
en-wikipedia-org-3485	354	2	to	to	IN
en-wikipedia-org-3485	354	3	these	these	DT
en-wikipedia-org-3485	354	4	authors	author	NNS
en-wikipedia-org-3485	354	5	,	,	,
en-wikipedia-org-3485	354	6	the	the	DT
en-wikipedia-org-3485	354	7	main	main	JJ
en-wikipedia-org-3485	354	8	neural	neural	JJ
en-wikipedia-org-3485	354	9	structures	structure	NNS
en-wikipedia-org-3485	354	10	involved	involve	VBN
en-wikipedia-org-3485	354	11	are	be	VBP
en-wikipedia-org-3485	354	12	:	:	:
en-wikipedia-org-3485	354	13	the	the	DT
en-wikipedia-org-3485	354	14	nucleus	nucleus	NN
en-wikipedia-org-3485	354	15	accumbens	accumben	VBZ
en-wikipedia-org-3485	354	16	,	,	,
en-wikipedia-org-3485	354	17	dorsal	dorsal	NN
en-wikipedia-org-3485	354	18	striatum	striatum	NN
en-wikipedia-org-3485	354	19	,	,	,
en-wikipedia-org-3485	354	20	orbitofrontal	orbitofrontal	NNP
en-wikipedia-org-3485	354	21	cortex	cortex	NNP
en-wikipedia-org-3485	354	22	,	,	,
en-wikipedia-org-3485	354	23	anterior	anterior	NNP
en-wikipedia-org-3485	354	24	cingulate	cingulate	NNP
en-wikipedia-org-3485	354	25	cortex	cortex	NNP
en-wikipedia-org-3485	354	26	,	,	,
en-wikipedia-org-3485	354	27	dorsolateral	dorsolateral	JJ
en-wikipedia-org-3485	354	28	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	354	29	cortex	cortex	NNP
en-wikipedia-org-3485	354	30	(	(	-LRB-
en-wikipedia-org-3485	354	31	DLPFC	DLPFC	NNP
en-wikipedia-org-3485	354	32	)	)	-RRB-
en-wikipedia-org-3485	354	33	,	,	,
en-wikipedia-org-3485	354	34	amygdala	amygdala	NNP
en-wikipedia-org-3485	354	35	,	,	,
en-wikipedia-org-3485	354	36	hippocampus	hippocampus	NNP
en-wikipedia-org-3485	354	37	and	and	CC
en-wikipedia-org-3485	354	38	insula	insula	NNP
en-wikipedia-org-3485	354	39	.	.	.
en-wikipedia-org-3485	355	1	^	^	NNP
en-wikipedia-org-3485	355	2	a	a	DT
en-wikipedia-org-3485	355	3	b	b	NNP
en-wikipedia-org-3485	355	4	Malenka	Malenka	NNP
en-wikipedia-org-3485	355	5	RC	RC	NNP
en-wikipedia-org-3485	355	6	,	,	,
en-wikipedia-org-3485	355	7	Nestler	Nestler	NNP
en-wikipedia-org-3485	355	8	EJ	EJ	NNP
en-wikipedia-org-3485	355	9	,	,	,
en-wikipedia-org-3485	355	10	Hyman	Hyman	NNP
en-wikipedia-org-3485	355	11	SE	SE	NNP
en-wikipedia-org-3485	355	12	(	(	-LRB-
en-wikipedia-org-3485	355	13	2009	2009	CD
en-wikipedia-org-3485	355	14	)	)	-RRB-
en-wikipedia-org-3485	355	15	.	.	.
en-wikipedia-org-3485	356	1	Sydor	Sydor	NNP
en-wikipedia-org-3485	356	2	A	A	NNP
en-wikipedia-org-3485	356	3	,	,	,
en-wikipedia-org-3485	356	4	Brown	Brown	NNP
en-wikipedia-org-3485	356	5	RY	RY	NNP
en-wikipedia-org-3485	356	6	(	(	-LRB-
en-wikipedia-org-3485	356	7	eds	eds	NNP
en-wikipedia-org-3485	356	8	.	.	.
en-wikipedia-org-3485	356	9	)	)	-RRB-
en-wikipedia-org-3485	356	10	.	.	.
en-wikipedia-org-3485	357	1	Molecular	Molecular	NNP
en-wikipedia-org-3485	357	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-3485	357	3	:	:	:
en-wikipedia-org-3485	357	4	A	A	NNP
en-wikipedia-org-3485	357	5	Foundation	Foundation	NNP
en-wikipedia-org-3485	357	6	for	for	IN
en-wikipedia-org-3485	357	7	Clinical	Clinical	NNP
en-wikipedia-org-3485	357	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	357	9	(	(	-LRB-
en-wikipedia-org-3485	357	10	2nd	2nd	NNP
en-wikipedia-org-3485	357	11	ed	ed	NNP
en-wikipedia-org-3485	357	12	.	.	.
en-wikipedia-org-3485	357	13	)	)	-RRB-
en-wikipedia-org-3485	357	14	.	.	.
en-wikipedia-org-3485	358	1	New	New	NNP
en-wikipedia-org-3485	358	2	York	York	NNP
en-wikipedia-org-3485	358	3	:	:	:
en-wikipedia-org-3485	358	4	McGraw	McGraw	NNP
en-wikipedia-org-3485	358	5	-	-	HYPH
en-wikipedia-org-3485	358	6	Hill	Hill	NNP
en-wikipedia-org-3485	358	7	Medical	Medical	NNP
en-wikipedia-org-3485	358	8	.	.	.
en-wikipedia-org-3485	359	1	pp	pp	NNP
en-wikipedia-org-3485	359	2	.	.	.
en-wikipedia-org-3485	360	1	365–366	365–366	CD
en-wikipedia-org-3485	360	2	,	,	,
en-wikipedia-org-3485	360	3	376	376	CD
en-wikipedia-org-3485	360	4	.	.	.
en-wikipedia-org-3485	361	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	361	2	 	  	_SP
en-wikipedia-org-3485	361	3	978	978	CD
en-wikipedia-org-3485	361	4	-	-	HYPH
en-wikipedia-org-3485	361	5	0	0	CD
en-wikipedia-org-3485	361	6	-	-	HYPH
en-wikipedia-org-3485	361	7	07	07	CD
en-wikipedia-org-3485	361	8	-	-	HYPH
en-wikipedia-org-3485	361	9	148127	148127	CD
en-wikipedia-org-3485	361	10	-	-	SYM
en-wikipedia-org-3485	361	11	4	4	CD
en-wikipedia-org-3485	361	12	.	.	.
en-wikipedia-org-3485	362	1	The	the	DT
en-wikipedia-org-3485	362	2	neural	neural	JJ
en-wikipedia-org-3485	362	3	substrates	substrate	NNS
en-wikipedia-org-3485	362	4	that	that	WDT
en-wikipedia-org-3485	362	5	underlie	underlie	VBP
en-wikipedia-org-3485	362	6	the	the	DT
en-wikipedia-org-3485	362	7	perception	perception	NN
en-wikipedia-org-3485	362	8	of	of	IN
en-wikipedia-org-3485	362	9	reward	reward	NN
en-wikipedia-org-3485	362	10	and	and	CC
en-wikipedia-org-3485	362	11	the	the	DT
en-wikipedia-org-3485	362	12	phenomenon	phenomenon	NN
en-wikipedia-org-3485	362	13	of	of	IN
en-wikipedia-org-3485	362	14	positive	positive	JJ
en-wikipedia-org-3485	362	15	reinforcement	reinforcement	NN
en-wikipedia-org-3485	362	16	are	be	VBP
en-wikipedia-org-3485	362	17	a	a	DT
en-wikipedia-org-3485	362	18	set	set	NN
en-wikipedia-org-3485	362	19	of	of	IN
en-wikipedia-org-3485	362	20	interconnected	interconnected	JJ
en-wikipedia-org-3485	362	21	forebrain	forebrain	NN
en-wikipedia-org-3485	362	22	structures	structure	NNS
en-wikipedia-org-3485	362	23	called	call	VBD
en-wikipedia-org-3485	362	24	brain	brain	NN
en-wikipedia-org-3485	362	25	reward	reward	NN
en-wikipedia-org-3485	362	26	pathways	pathway	NNS
en-wikipedia-org-3485	362	27	;	;	,
en-wikipedia-org-3485	362	28	these	these	DT
en-wikipedia-org-3485	362	29	include	include	VBP
en-wikipedia-org-3485	362	30	the	the	DT
en-wikipedia-org-3485	362	31	nucleus	nucleus	NN
en-wikipedia-org-3485	362	32	accumbens	accumben	NNS
en-wikipedia-org-3485	362	33	(	(	-LRB-
en-wikipedia-org-3485	362	34	NAc	NAc	NNS
en-wikipedia-org-3485	362	35	;	;	:
en-wikipedia-org-3485	362	36	the	the	DT
en-wikipedia-org-3485	362	37	major	major	JJ
en-wikipedia-org-3485	362	38	component	component	NN
en-wikipedia-org-3485	362	39	of	of	IN
en-wikipedia-org-3485	362	40	the	the	DT
en-wikipedia-org-3485	362	41	ventral	ventral	JJ
en-wikipedia-org-3485	362	42	striatum	striatum	NN
en-wikipedia-org-3485	362	43	)	)	-RRB-
en-wikipedia-org-3485	362	44	,	,	,
en-wikipedia-org-3485	362	45	the	the	DT
en-wikipedia-org-3485	362	46	basal	basal	NN
en-wikipedia-org-3485	362	47	forebrain	forebrain	NNP
en-wikipedia-org-3485	362	48	(	(	-LRB-
en-wikipedia-org-3485	362	49	components	component	NNS
en-wikipedia-org-3485	362	50	of	of	IN
en-wikipedia-org-3485	362	51	which	which	WDT
en-wikipedia-org-3485	362	52	have	have	VBP
en-wikipedia-org-3485	362	53	been	be	VBN
en-wikipedia-org-3485	362	54	termed	term	VBN
en-wikipedia-org-3485	362	55	the	the	DT
en-wikipedia-org-3485	362	56	extended	extended	JJ
en-wikipedia-org-3485	362	57	amygdala	amygdala	NNP
en-wikipedia-org-3485	362	58	,	,	,
en-wikipedia-org-3485	362	59	as	as	IN
en-wikipedia-org-3485	362	60	discussed	discuss	VBN
en-wikipedia-org-3485	362	61	later	later	RB
en-wikipedia-org-3485	362	62	in	in	IN
en-wikipedia-org-3485	362	63	this	this	DT
en-wikipedia-org-3485	362	64	chapter	chapter	NN
en-wikipedia-org-3485	362	65	)	)	-RRB-
en-wikipedia-org-3485	362	66	,	,	,
en-wikipedia-org-3485	362	67	hippocampus	hippocampus	NNP
en-wikipedia-org-3485	362	68	,	,	,
en-wikipedia-org-3485	362	69	hypothalamus	hypothalamus	UH
en-wikipedia-org-3485	362	70	,	,	,
en-wikipedia-org-3485	362	71	and	and	CC
en-wikipedia-org-3485	362	72	frontal	frontal	JJ
en-wikipedia-org-3485	362	73	regions	region	NNS
en-wikipedia-org-3485	362	74	of	of	IN
en-wikipedia-org-3485	362	75	cerebral	cerebral	JJ
en-wikipedia-org-3485	362	76	cortex	cortex	NNP
en-wikipedia-org-3485	362	77	.	.	.
en-wikipedia-org-3485	363	1	These	these	DT
en-wikipedia-org-3485	363	2	structures	structure	NNS
en-wikipedia-org-3485	363	3	receive	receive	VBP
en-wikipedia-org-3485	363	4	rich	rich	JJ
en-wikipedia-org-3485	363	5	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	363	6	innervation	innervation	NN
en-wikipedia-org-3485	363	7	from	from	IN
en-wikipedia-org-3485	363	8	the	the	DT
en-wikipedia-org-3485	363	9	ventral	ventral	JJ
en-wikipedia-org-3485	363	10	tegmental	tegmental	JJ
en-wikipedia-org-3485	363	11	area	area	NN
en-wikipedia-org-3485	363	12	(	(	-LRB-
en-wikipedia-org-3485	363	13	VTA	VTA	NNP
en-wikipedia-org-3485	363	14	)	)	-RRB-
en-wikipedia-org-3485	363	15	of	of	IN
en-wikipedia-org-3485	363	16	the	the	DT
en-wikipedia-org-3485	363	17	midbrain	midbrain	NN
en-wikipedia-org-3485	363	18	.	.	.
en-wikipedia-org-3485	364	1	Addictive	addictive	JJ
en-wikipedia-org-3485	364	2	drugs	drug	NNS
en-wikipedia-org-3485	364	3	are	be	VBP
en-wikipedia-org-3485	364	4	rewarding	reward	VBG
en-wikipedia-org-3485	364	5	and	and	CC
en-wikipedia-org-3485	364	6	reinforcing	reinforce	VBG
en-wikipedia-org-3485	364	7	because	because	IN
en-wikipedia-org-3485	364	8	they	-PRON-	PRP
en-wikipedia-org-3485	364	9	act	act	VBP
en-wikipedia-org-3485	364	10	in	in	IN
en-wikipedia-org-3485	364	11	brain	brain	NN
en-wikipedia-org-3485	364	12	reward	reward	NN
en-wikipedia-org-3485	364	13	pathways	pathway	NNS
en-wikipedia-org-3485	364	14	to	to	TO
en-wikipedia-org-3485	364	15	enhance	enhance	VB
en-wikipedia-org-3485	364	16	either	either	DT
en-wikipedia-org-3485	364	17	dopamine	dopamine	NN
en-wikipedia-org-3485	364	18	release	release	NN
en-wikipedia-org-3485	364	19	or	or	CC
en-wikipedia-org-3485	364	20	the	the	DT
en-wikipedia-org-3485	364	21	effects	effect	NNS
en-wikipedia-org-3485	364	22	of	of	IN
en-wikipedia-org-3485	364	23	dopamine	dopamine	NN
en-wikipedia-org-3485	364	24	in	in	IN
en-wikipedia-org-3485	364	25	the	the	DT
en-wikipedia-org-3485	364	26	NAc	NAc	NNS
en-wikipedia-org-3485	364	27	or	or	CC
en-wikipedia-org-3485	364	28	related	related	JJ
en-wikipedia-org-3485	364	29	structures	structure	NNS
en-wikipedia-org-3485	364	30	,	,	,
en-wikipedia-org-3485	364	31	or	or	CC
en-wikipedia-org-3485	364	32	because	because	IN
en-wikipedia-org-3485	364	33	they	-PRON-	PRP
en-wikipedia-org-3485	364	34	produce	produce	VBP
en-wikipedia-org-3485	364	35	effects	effect	NNS
en-wikipedia-org-3485	364	36	similar	similar	JJ
en-wikipedia-org-3485	364	37	to	to	IN
en-wikipedia-org-3485	364	38	dopamine	dopamine	NN
en-wikipedia-org-3485	364	39	.	.	.
en-wikipedia-org-3485	365	1	...	...	:
en-wikipedia-org-3485	365	2	A	a	DT
en-wikipedia-org-3485	365	3	macrostructure	macrostructure	NN
en-wikipedia-org-3485	365	4	postulated	postulate	VBN
en-wikipedia-org-3485	365	5	to	to	TO
en-wikipedia-org-3485	365	6	integrate	integrate	VB
en-wikipedia-org-3485	365	7	many	many	JJ
en-wikipedia-org-3485	365	8	of	of	IN
en-wikipedia-org-3485	365	9	the	the	DT
en-wikipedia-org-3485	365	10	functions	function	NNS
en-wikipedia-org-3485	365	11	of	of	IN
en-wikipedia-org-3485	365	12	this	this	DT
en-wikipedia-org-3485	365	13	circuit	circuit	NN
en-wikipedia-org-3485	365	14	is	be	VBZ
en-wikipedia-org-3485	365	15	described	describe	VBN
en-wikipedia-org-3485	365	16	by	by	IN
en-wikipedia-org-3485	365	17	some	some	DT
en-wikipedia-org-3485	365	18	investigators	investigator	NNS
en-wikipedia-org-3485	365	19	as	as	IN
en-wikipedia-org-3485	365	20	the	the	DT
en-wikipedia-org-3485	365	21	extended	extended	JJ
en-wikipedia-org-3485	365	22	amygdala	amygdala	NNP
en-wikipedia-org-3485	365	23	.	.	.
en-wikipedia-org-3485	366	1	The	the	DT
en-wikipedia-org-3485	366	2	extended	extended	JJ
en-wikipedia-org-3485	366	3	amygdala	amygdala	NNP
en-wikipedia-org-3485	366	4	is	be	VBZ
en-wikipedia-org-3485	366	5	said	say	VBN
en-wikipedia-org-3485	366	6	to	to	TO
en-wikipedia-org-3485	366	7	comprise	comprise	VB
en-wikipedia-org-3485	366	8	several	several	JJ
en-wikipedia-org-3485	366	9	basal	basal	NN
en-wikipedia-org-3485	366	10	forebrain	forebrain	NN
en-wikipedia-org-3485	366	11	structures	structure	NNS
en-wikipedia-org-3485	366	12	that	that	WDT
en-wikipedia-org-3485	366	13	share	share	VBP
en-wikipedia-org-3485	366	14	similar	similar	JJ
en-wikipedia-org-3485	366	15	morphology	morphology	NN
en-wikipedia-org-3485	366	16	,	,	,
en-wikipedia-org-3485	366	17	immunocytochemical	immunocytochemical	JJ
en-wikipedia-org-3485	366	18	features	feature	NNS
en-wikipedia-org-3485	366	19	,	,	,
en-wikipedia-org-3485	366	20	and	and	CC
en-wikipedia-org-3485	366	21	connectivity	connectivity	NN
en-wikipedia-org-3485	366	22	and	and	CC
en-wikipedia-org-3485	366	23	that	that	WDT
en-wikipedia-org-3485	366	24	are	be	VBP
en-wikipedia-org-3485	366	25	well	well	RB
en-wikipedia-org-3485	366	26	suited	suited	JJ
en-wikipedia-org-3485	366	27	to	to	IN
en-wikipedia-org-3485	366	28	mediating	mediate	VBG
en-wikipedia-org-3485	366	29	aspects	aspect	NNS
en-wikipedia-org-3485	366	30	of	of	IN
en-wikipedia-org-3485	366	31	reward	reward	NN
en-wikipedia-org-3485	366	32	function	function	NN
en-wikipedia-org-3485	366	33	;	;	:
en-wikipedia-org-3485	366	34	these	these	DT
en-wikipedia-org-3485	366	35	include	include	VBP
en-wikipedia-org-3485	366	36	the	the	DT
en-wikipedia-org-3485	366	37	bed	bed	NN
en-wikipedia-org-3485	366	38	nucleus	nucleus	NN
en-wikipedia-org-3485	366	39	of	of	IN
en-wikipedia-org-3485	366	40	the	the	DT
en-wikipedia-org-3485	366	41	stria	stria	NNP
en-wikipedia-org-3485	366	42	terminalis	terminalis	NNP
en-wikipedia-org-3485	366	43	,	,	,
en-wikipedia-org-3485	366	44	the	the	DT
en-wikipedia-org-3485	366	45	central	central	NNP
en-wikipedia-org-3485	366	46	medial	medial	NNP
en-wikipedia-org-3485	366	47	amygdala	amygdala	NNP
en-wikipedia-org-3485	366	48	,	,	,
en-wikipedia-org-3485	366	49	the	the	DT
en-wikipedia-org-3485	366	50	shell	shell	NN
en-wikipedia-org-3485	366	51	of	of	IN
en-wikipedia-org-3485	366	52	the	the	DT
en-wikipedia-org-3485	366	53	NAc	NAc	NNS
en-wikipedia-org-3485	366	54	,	,	,
en-wikipedia-org-3485	366	55	and	and	CC
en-wikipedia-org-3485	366	56	the	the	DT
en-wikipedia-org-3485	366	57	sublenticular	sublenticular	JJ
en-wikipedia-org-3485	366	58	substantia	substantia	NNP
en-wikipedia-org-3485	366	59	innominata	innominata	NNP
en-wikipedia-org-3485	366	60	.	.	.
en-wikipedia-org-3485	367	1	^	^	NNP
en-wikipedia-org-3485	367	2	a	a	DT
en-wikipedia-org-3485	367	3	b	b	NN
en-wikipedia-org-3485	367	4	Richard	Richard	NNP
en-wikipedia-org-3485	367	5	JM	JM	NNP
en-wikipedia-org-3485	367	6	,	,	,
en-wikipedia-org-3485	367	7	Castro	Castro	NNP
en-wikipedia-org-3485	367	8	DC	DC	NNP
en-wikipedia-org-3485	367	9	,	,	,
en-wikipedia-org-3485	367	10	Difeliceantonio	Difeliceantonio	NNP
en-wikipedia-org-3485	367	11	AG	AG	NNP
en-wikipedia-org-3485	367	12	,	,	,
en-wikipedia-org-3485	367	13	Robinson	Robinson	NNP
en-wikipedia-org-3485	367	14	MJ	MJ	NNP
en-wikipedia-org-3485	367	15	,	,	,
en-wikipedia-org-3485	367	16	Berridge	Berridge	NNP
en-wikipedia-org-3485	367	17	KC	KC	NNP
en-wikipedia-org-3485	367	18	(	(	-LRB-
en-wikipedia-org-3485	367	19	November	November	NNP
en-wikipedia-org-3485	367	20	2013	2013	CD
en-wikipedia-org-3485	367	21	)	)	-RRB-
en-wikipedia-org-3485	367	22	.	.	.
en-wikipedia-org-3485	368	1	"	"	``
en-wikipedia-org-3485	368	2	Mapping	map	VBG
en-wikipedia-org-3485	368	3	brain	brain	NN
en-wikipedia-org-3485	368	4	circuits	circuit	NNS
en-wikipedia-org-3485	368	5	of	of	IN
en-wikipedia-org-3485	368	6	reward	reward	NN
en-wikipedia-org-3485	368	7	and	and	CC
en-wikipedia-org-3485	368	8	motivation	motivation	NN
en-wikipedia-org-3485	368	9	:	:	:
en-wikipedia-org-3485	368	10	in	in	IN
en-wikipedia-org-3485	368	11	the	the	DT
en-wikipedia-org-3485	368	12	footsteps	footstep	NNS
en-wikipedia-org-3485	368	13	of	of	IN
en-wikipedia-org-3485	368	14	Ann	Ann	NNP
en-wikipedia-org-3485	368	15	Kelley	Kelley	NNP
en-wikipedia-org-3485	368	16	"	"	''
en-wikipedia-org-3485	368	17	.	.	.
en-wikipedia-org-3485	369	1	Neurosci	Neurosci	NNP
en-wikipedia-org-3485	369	2	.	.	.
en-wikipedia-org-3485	370	1	Biobehav	Biobehav	NNP
en-wikipedia-org-3485	370	2	.	.	.
en-wikipedia-org-3485	371	1	Rev.	Rev.	NNP
en-wikipedia-org-3485	372	1	37	37	CD
en-wikipedia-org-3485	372	2	(	(	-LRB-
en-wikipedia-org-3485	372	3	9	9	CD
en-wikipedia-org-3485	372	4	Pt	Pt	NNP
en-wikipedia-org-3485	372	5	A	A	NNP
en-wikipedia-org-3485	372	6	)	)	-RRB-
en-wikipedia-org-3485	372	7	:	:	:
en-wikipedia-org-3485	372	8	1919–1931	1919–1931	CD
en-wikipedia-org-3485	372	9	.	.	.
en-wikipedia-org-3485	373	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	373	2	/	/	SYM
en-wikipedia-org-3485	373	3	j.neubiorev.2012.12.008	j.neubiorev.2012.12.008	CD
en-wikipedia-org-3485	373	4	.	.	.
en-wikipedia-org-3485	374	1	PMC	PMC	NNP
en-wikipedia-org-3485	374	2	 	  	_SP
en-wikipedia-org-3485	374	3	3706488	3706488	CD
en-wikipedia-org-3485	374	4	.	.	.
en-wikipedia-org-3485	375	1	PMID	PMID	NNP
en-wikipedia-org-3485	375	2	 	  	_SP
en-wikipedia-org-3485	375	3	23261404	23261404	CD
en-wikipedia-org-3485	375	4	.	.	.
en-wikipedia-org-3485	376	1	Figure	figure	NN
en-wikipedia-org-3485	376	2	3	3	CD
en-wikipedia-org-3485	376	3	:	:	:
en-wikipedia-org-3485	376	4	Neural	neural	JJ
en-wikipedia-org-3485	376	5	circuits	circuit	NNS
en-wikipedia-org-3485	376	6	underlying	underlie	VBG
en-wikipedia-org-3485	376	7	motivated	motivated	JJ
en-wikipedia-org-3485	376	8	'	'	''
en-wikipedia-org-3485	376	9	wanting	wanting	NN
en-wikipedia-org-3485	376	10	'	'	''
en-wikipedia-org-3485	376	11	and	and	CC
en-wikipedia-org-3485	376	12	hedonic	hedonic	JJ
en-wikipedia-org-3485	376	13	'	'	''
en-wikipedia-org-3485	376	14	liking	liking	NN
en-wikipedia-org-3485	376	15	'	'	''
en-wikipedia-org-3485	376	16	.	.	.
en-wikipedia-org-3485	377	1	^	^	NNP
en-wikipedia-org-3485	377	2	Luo	Luo	NNP
en-wikipedia-org-3485	377	3	M	M	NNP
en-wikipedia-org-3485	377	4	,	,	,
en-wikipedia-org-3485	377	5	Zhou	Zhou	NNP
en-wikipedia-org-3485	377	6	J	J	NNP
en-wikipedia-org-3485	377	7	,	,	,
en-wikipedia-org-3485	377	8	Liu	Liu	NNP
en-wikipedia-org-3485	377	9	Z	Z	NNP
en-wikipedia-org-3485	377	10	(	(	-LRB-
en-wikipedia-org-3485	377	11	August	August	NNP
en-wikipedia-org-3485	377	12	2015	2015	CD
en-wikipedia-org-3485	377	13	)	)	-RRB-
en-wikipedia-org-3485	377	14	.	.	.
en-wikipedia-org-3485	378	1	"	"	``
en-wikipedia-org-3485	378	2	Reward	reward	NN
en-wikipedia-org-3485	378	3	processing	processing	NN
en-wikipedia-org-3485	378	4	by	by	IN
en-wikipedia-org-3485	378	5	the	the	DT
en-wikipedia-org-3485	378	6	dorsal	dorsal	NN
en-wikipedia-org-3485	378	7	raphe	raphe	NN
en-wikipedia-org-3485	378	8	nucleus	nucleus	NNP
en-wikipedia-org-3485	378	9	:	:	:
en-wikipedia-org-3485	378	10	5-HT	5-ht	CD
en-wikipedia-org-3485	378	11	and	and	CC
en-wikipedia-org-3485	378	12	beyond	beyond	IN
en-wikipedia-org-3485	378	13	"	"	''
en-wikipedia-org-3485	378	14	.	.	.
en-wikipedia-org-3485	379	1	Learn	learn	VB
en-wikipedia-org-3485	379	2	.	.	.
en-wikipedia-org-3485	380	1	Mem	Mem	NNP
en-wikipedia-org-3485	380	2	.	.	.
en-wikipedia-org-3485	381	1	22	22	CD
en-wikipedia-org-3485	381	2	(	(	-LRB-
en-wikipedia-org-3485	381	3	9	9	CD
en-wikipedia-org-3485	381	4	)	)	-RRB-
en-wikipedia-org-3485	381	5	:	:	:
en-wikipedia-org-3485	381	6	452–460	452–460	CD
en-wikipedia-org-3485	381	7	.	.	.
en-wikipedia-org-3485	382	1	doi:10.1101	doi:10.1101	NNP
en-wikipedia-org-3485	382	2	/	/	SYM
en-wikipedia-org-3485	382	3	lm.037317.114	lm.037317.114	NNP
en-wikipedia-org-3485	382	4	.	.	.
en-wikipedia-org-3485	383	1	PMC	PMC	NNP
en-wikipedia-org-3485	383	2	 	  	_SP
en-wikipedia-org-3485	383	3	4561406	4561406	CD
en-wikipedia-org-3485	383	4	.	.	.
en-wikipedia-org-3485	384	1	PMID	PMID	NNP
en-wikipedia-org-3485	384	2	 	  	_SP
en-wikipedia-org-3485	384	3	26286655	26286655	CD
en-wikipedia-org-3485	384	4	.	.	.
en-wikipedia-org-3485	385	1	^	^	NNP
en-wikipedia-org-3485	385	2	Moulton	Moulton	NNP
en-wikipedia-org-3485	385	3	EA	EA	NNP
en-wikipedia-org-3485	385	4	,	,	,
en-wikipedia-org-3485	385	5	Elman	Elman	NNP
en-wikipedia-org-3485	385	6	I	I	NNP
en-wikipedia-org-3485	385	7	,	,	,
en-wikipedia-org-3485	385	8	Becerra	Becerra	NNP
en-wikipedia-org-3485	385	9	LR	LR	NNP
en-wikipedia-org-3485	385	10	,	,	,
en-wikipedia-org-3485	385	11	Goldstein	Goldstein	NNP
en-wikipedia-org-3485	385	12	RZ	RZ	NNP
en-wikipedia-org-3485	385	13	,	,	,
en-wikipedia-org-3485	385	14	Borsook	Borsook	NNP
en-wikipedia-org-3485	385	15	D	d	NN
en-wikipedia-org-3485	385	16	(	(	-LRB-
en-wikipedia-org-3485	385	17	May	May	NNP
en-wikipedia-org-3485	385	18	2014	2014	CD
en-wikipedia-org-3485	385	19	)	)	-RRB-
en-wikipedia-org-3485	385	20	.	.	.
en-wikipedia-org-3485	386	1	"	"	``
en-wikipedia-org-3485	386	2	The	the	DT
en-wikipedia-org-3485	386	3	cerebellum	cerebellum	NN
en-wikipedia-org-3485	386	4	and	and	CC
en-wikipedia-org-3485	386	5	addiction	addiction	NN
en-wikipedia-org-3485	386	6	:	:	:
en-wikipedia-org-3485	386	7	insights	insight	NNS
en-wikipedia-org-3485	386	8	gained	gain	VBN
en-wikipedia-org-3485	386	9	from	from	IN
en-wikipedia-org-3485	386	10	neuroimaging	neuroimage	VBG
en-wikipedia-org-3485	386	11	research	research	NN
en-wikipedia-org-3485	386	12	"	"	''
en-wikipedia-org-3485	386	13	.	.	.
en-wikipedia-org-3485	387	1	Addict	Addict	NNP
en-wikipedia-org-3485	387	2	.	.	.
en-wikipedia-org-3485	388	1	Biol	Biol	NNP
en-wikipedia-org-3485	388	2	.	.	.
en-wikipedia-org-3485	389	1	19	19	CD
en-wikipedia-org-3485	389	2	(	(	-LRB-
en-wikipedia-org-3485	389	3	3	3	CD
en-wikipedia-org-3485	389	4	)	)	-RRB-
en-wikipedia-org-3485	389	5	:	:	:
en-wikipedia-org-3485	389	6	317–331	317–331	CD
en-wikipedia-org-3485	389	7	.	.	.
en-wikipedia-org-3485	390	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-3485	390	2	/	/	SYM
en-wikipedia-org-3485	390	3	adb.12101	adb.12101	NN
en-wikipedia-org-3485	390	4	.	.	.
en-wikipedia-org-3485	391	1	PMC	PMC	NNP
en-wikipedia-org-3485	391	2	 	  	_SP
en-wikipedia-org-3485	391	3	4031616	4031616	CD
en-wikipedia-org-3485	391	4	.	.	.
en-wikipedia-org-3485	392	1	PMID	PMID	NNP
en-wikipedia-org-3485	392	2	 	  	_SP
en-wikipedia-org-3485	392	3	24851284	24851284	CD
en-wikipedia-org-3485	392	4	.	.	.
en-wikipedia-org-3485	393	1	^	^	NFP
en-wikipedia-org-3485	393	2	Caligiore	Caligiore	NNP
en-wikipedia-org-3485	393	3	D	D	NNP
en-wikipedia-org-3485	393	4	,	,	,
en-wikipedia-org-3485	393	5	Pezzulo	Pezzulo	NNP
en-wikipedia-org-3485	393	6	G	G	NNP
en-wikipedia-org-3485	393	7	,	,	,
en-wikipedia-org-3485	393	8	Baldassarre	Baldassarre	NNP
en-wikipedia-org-3485	393	9	G	G	NNP
en-wikipedia-org-3485	393	10	,	,	,
en-wikipedia-org-3485	393	11	Bostan	Bostan	NNP
en-wikipedia-org-3485	393	12	AC	AC	NNP
en-wikipedia-org-3485	393	13	,	,	,
en-wikipedia-org-3485	393	14	Strick	Strick	NNP
en-wikipedia-org-3485	393	15	PL	PL	NNP
en-wikipedia-org-3485	393	16	,	,	,
en-wikipedia-org-3485	393	17	Doya	Doya	NNP
en-wikipedia-org-3485	393	18	K	K	NNP
en-wikipedia-org-3485	393	19	,	,	,
en-wikipedia-org-3485	393	20	Helmich	Helmich	NNP
en-wikipedia-org-3485	393	21	RC	RC	NNP
en-wikipedia-org-3485	393	22	,	,	,
en-wikipedia-org-3485	393	23	Dirkx	Dirkx	NNP
en-wikipedia-org-3485	393	24	M	M	NNP
en-wikipedia-org-3485	393	25	,	,	,
en-wikipedia-org-3485	393	26	Houk	Houk	NNP
en-wikipedia-org-3485	393	27	J	J	NNP
en-wikipedia-org-3485	393	28	,	,	,
en-wikipedia-org-3485	393	29	Jörntell	Jörntell	NNP
en-wikipedia-org-3485	393	30	H	H	NNP
en-wikipedia-org-3485	393	31	,	,	,
en-wikipedia-org-3485	393	32	Lago	Lago	NNP
en-wikipedia-org-3485	393	33	-	-	HYPH
en-wikipedia-org-3485	393	34	Rodriguez	Rodriguez	NNP
en-wikipedia-org-3485	393	35	A	A	NNP
en-wikipedia-org-3485	393	36	,	,	,
en-wikipedia-org-3485	393	37	Galea	Galea	NNP
en-wikipedia-org-3485	393	38	JM	JM	NNP
en-wikipedia-org-3485	393	39	,	,	,
en-wikipedia-org-3485	393	40	Miall	Miall	NNP
en-wikipedia-org-3485	393	41	RC	RC	NNP
en-wikipedia-org-3485	393	42	,	,	,
en-wikipedia-org-3485	393	43	Popa	Popa	NNP
en-wikipedia-org-3485	393	44	T	T	NNP
en-wikipedia-org-3485	393	45	,	,	,
en-wikipedia-org-3485	393	46	Kishore	Kishore	NNP
en-wikipedia-org-3485	393	47	A	A	NNP
en-wikipedia-org-3485	393	48	,	,	,
en-wikipedia-org-3485	393	49	Verschure	Verschure	NNP
en-wikipedia-org-3485	393	50	PF	PF	NNP
en-wikipedia-org-3485	393	51	,	,	,
en-wikipedia-org-3485	393	52	Zucca	Zucca	NNP
en-wikipedia-org-3485	393	53	R	R	NNP
en-wikipedia-org-3485	393	54	,	,	,
en-wikipedia-org-3485	393	55	Herreros	Herreros	NNP
en-wikipedia-org-3485	393	56	I	-PRON-	PRP
en-wikipedia-org-3485	393	57	(	(	-LRB-
en-wikipedia-org-3485	393	58	February	February	NNP
en-wikipedia-org-3485	393	59	2017	2017	CD
en-wikipedia-org-3485	393	60	)	)	-RRB-
en-wikipedia-org-3485	393	61	.	.	.
en-wikipedia-org-3485	394	1	"	"	``
en-wikipedia-org-3485	394	2	Consensus	Consensus	NNP
en-wikipedia-org-3485	394	3	Paper	Paper	NNP
en-wikipedia-org-3485	394	4	:	:	:
en-wikipedia-org-3485	394	5	Towards	towards	IN
en-wikipedia-org-3485	394	6	a	a	DT
en-wikipedia-org-3485	394	7	Systems	Systems	NNP
en-wikipedia-org-3485	394	8	-	-	HYPH
en-wikipedia-org-3485	394	9	Level	level	NN
en-wikipedia-org-3485	394	10	View	view	NN
en-wikipedia-org-3485	394	11	of	of	IN
en-wikipedia-org-3485	394	12	Cerebellar	Cerebellar	NNP
en-wikipedia-org-3485	394	13	Function	Function	NNP
en-wikipedia-org-3485	394	14	:	:	:
en-wikipedia-org-3485	394	15	the	the	DT
en-wikipedia-org-3485	394	16	Interplay	Interplay	NNP
en-wikipedia-org-3485	394	17	Between	between	IN
en-wikipedia-org-3485	394	18	Cerebellum	Cerebellum	NNP
en-wikipedia-org-3485	394	19	,	,	,
en-wikipedia-org-3485	394	20	Basal	Basal	NNP
en-wikipedia-org-3485	394	21	Ganglia	Ganglia	NNP
en-wikipedia-org-3485	394	22	,	,	,
en-wikipedia-org-3485	394	23	and	and	CC
en-wikipedia-org-3485	394	24	Cortex	Cortex	NNP
en-wikipedia-org-3485	394	25	"	"	''
en-wikipedia-org-3485	394	26	.	.	.
en-wikipedia-org-3485	395	1	Cerebellum	cerebellum	NN
en-wikipedia-org-3485	395	2	.	.	.
en-wikipedia-org-3485	396	1	16	16	CD
en-wikipedia-org-3485	396	2	(	(	-LRB-
en-wikipedia-org-3485	396	3	1	1	CD
en-wikipedia-org-3485	396	4	)	)	-RRB-
en-wikipedia-org-3485	396	5	:	:	:
en-wikipedia-org-3485	396	6	203–229	203–229	CD
en-wikipedia-org-3485	396	7	.	.	.
en-wikipedia-org-3485	397	1	doi:10.1007	doi:10.1007	NNP
en-wikipedia-org-3485	397	2	/	/	SYM
en-wikipedia-org-3485	397	3	s12311	s12311	NNP
en-wikipedia-org-3485	397	4	-	-	HYPH
en-wikipedia-org-3485	397	5	016	016	CD
en-wikipedia-org-3485	397	6	-	-	HYPH
en-wikipedia-org-3485	397	7	0763	0763	CD
en-wikipedia-org-3485	397	8	-	-	HYPH
en-wikipedia-org-3485	397	9	3	3	CD
en-wikipedia-org-3485	397	10	.	.	.
en-wikipedia-org-3485	398	1	PMC	PMC	NNP
en-wikipedia-org-3485	398	2	 	  	_SP
en-wikipedia-org-3485	398	3	5243918	5243918	CD
en-wikipedia-org-3485	398	4	.	.	.
en-wikipedia-org-3485	399	1	PMID	PMID	NNP
en-wikipedia-org-3485	399	2	 	  	_SP
en-wikipedia-org-3485	399	3	26873754	26873754	CD
en-wikipedia-org-3485	399	4	.	.	.
en-wikipedia-org-3485	400	1	^	^	NNP
en-wikipedia-org-3485	400	2	Ogawa	Ogawa	NNP
en-wikipedia-org-3485	400	3	,	,	,
en-wikipedia-org-3485	400	4	SK	SK	NNP
en-wikipedia-org-3485	400	5	;	;	:
en-wikipedia-org-3485	400	6	Watabe	Watabe	NNP
en-wikipedia-org-3485	400	7	-	-	HYPH
en-wikipedia-org-3485	400	8	Uchida	Uchida	NNP
en-wikipedia-org-3485	400	9	,	,	,
en-wikipedia-org-3485	400	10	M	M	NNP
en-wikipedia-org-3485	400	11	(	(	-LRB-
en-wikipedia-org-3485	400	12	2018	2018	CD
en-wikipedia-org-3485	400	13	)	)	-RRB-
en-wikipedia-org-3485	400	14	.	.	.
en-wikipedia-org-3485	401	1	"	"	``
en-wikipedia-org-3485	401	2	Organization	Organization	NNP
en-wikipedia-org-3485	401	3	of	of	IN
en-wikipedia-org-3485	401	4	dopamine	dopamine	NN
en-wikipedia-org-3485	401	5	and	and	CC
en-wikipedia-org-3485	401	6	serotonin	serotonin	NN
en-wikipedia-org-3485	401	7	system	system	NN
en-wikipedia-org-3485	401	8	:	:	:
en-wikipedia-org-3485	401	9	Anatomical	anatomical	JJ
en-wikipedia-org-3485	401	10	and	and	CC
en-wikipedia-org-3485	401	11	functional	functional	JJ
en-wikipedia-org-3485	401	12	mapping	mapping	NN
en-wikipedia-org-3485	401	13	of	of	IN
en-wikipedia-org-3485	401	14	monosynaptic	monosynaptic	JJ
en-wikipedia-org-3485	401	15	inputs	input	NNS
en-wikipedia-org-3485	401	16	using	use	VBG
en-wikipedia-org-3485	401	17	rabies	rabie	NNS
en-wikipedia-org-3485	401	18	virus	virus	NN
en-wikipedia-org-3485	401	19	"	"	''
en-wikipedia-org-3485	401	20	.	.	.
en-wikipedia-org-3485	402	1	Pharmacology	Pharmacology	NNP
en-wikipedia-org-3485	402	2	Biochemistry	Biochemistry	NNP
en-wikipedia-org-3485	402	3	and	and	CC
en-wikipedia-org-3485	402	4	Behavior	Behavior	NNP
en-wikipedia-org-3485	402	5	.	.	.
en-wikipedia-org-3485	403	1	174	174	CD
en-wikipedia-org-3485	403	2	:	:	:
en-wikipedia-org-3485	403	3	9–22	9–22	CD
en-wikipedia-org-3485	403	4	.	.	.
en-wikipedia-org-3485	404	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	404	2	/	/	SYM
en-wikipedia-org-3485	404	3	j.pbb.2017.05.001	j.pbb.2017.05.001	NNP
en-wikipedia-org-3485	404	4	.	.	.
en-wikipedia-org-3485	405	1	PMID	PMID	NNP
en-wikipedia-org-3485	405	2	 	  	_SP
en-wikipedia-org-3485	405	3	28476484	28476484	CD
en-wikipedia-org-3485	405	4	.	.	.
en-wikipedia-org-3485	406	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	406	2	 	  	_SP
en-wikipedia-org-3485	406	3	5089422	5089422	CD
en-wikipedia-org-3485	406	4	.	.	.
en-wikipedia-org-3485	407	1	^	^	NFP
en-wikipedia-org-3485	407	2	Morales	Morales	NNP
en-wikipedia-org-3485	407	3	,	,	,
en-wikipedia-org-3485	407	4	M	M	NNP
en-wikipedia-org-3485	407	5	;	;	:
en-wikipedia-org-3485	407	6	Margolis	Margolis	NNP
en-wikipedia-org-3485	407	7	,	,	,
en-wikipedia-org-3485	407	8	EB	EB	NNP
en-wikipedia-org-3485	407	9	(	(	-LRB-
en-wikipedia-org-3485	407	10	February	February	NNP
en-wikipedia-org-3485	407	11	2017	2017	CD
en-wikipedia-org-3485	407	12	)	)	-RRB-
en-wikipedia-org-3485	407	13	.	.	.
en-wikipedia-org-3485	408	1	"	"	``
en-wikipedia-org-3485	408	2	Ventral	ventral	JJ
en-wikipedia-org-3485	408	3	tegmental	tegmental	JJ
en-wikipedia-org-3485	408	4	area	area	NN
en-wikipedia-org-3485	408	5	:	:	:
en-wikipedia-org-3485	408	6	cellular	cellular	JJ
en-wikipedia-org-3485	408	7	heterogeneity	heterogeneity	NN
en-wikipedia-org-3485	408	8	,	,	,
en-wikipedia-org-3485	408	9	connectivity	connectivity	NN
en-wikipedia-org-3485	408	10	and	and	CC
en-wikipedia-org-3485	408	11	behaviour	behaviour	NN
en-wikipedia-org-3485	408	12	"	"	''
en-wikipedia-org-3485	408	13	.	.	.
en-wikipedia-org-3485	409	1	Nature	Nature	NNP
en-wikipedia-org-3485	409	2	Reviews	Reviews	NNPS
en-wikipedia-org-3485	409	3	.	.	.
en-wikipedia-org-3485	410	1	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	410	2	.	.	.
en-wikipedia-org-3485	411	1	18	18	CD
en-wikipedia-org-3485	411	2	(	(	-LRB-
en-wikipedia-org-3485	411	3	2	2	CD
en-wikipedia-org-3485	411	4	)	)	-RRB-
en-wikipedia-org-3485	411	5	:	:	:
en-wikipedia-org-3485	411	6	73–85	73–85	CD
en-wikipedia-org-3485	411	7	.	.	.
en-wikipedia-org-3485	412	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-3485	412	2	/	/	SYM
en-wikipedia-org-3485	412	3	nrn.2016.165	nrn.2016.165	NNP
en-wikipedia-org-3485	412	4	.	.	.
en-wikipedia-org-3485	413	1	PMID	PMID	NNP
en-wikipedia-org-3485	413	2	 	  	_SP
en-wikipedia-org-3485	413	3	28053327	28053327	CD
en-wikipedia-org-3485	413	4	.	.	.
en-wikipedia-org-3485	414	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	414	2	 	  	_SP
en-wikipedia-org-3485	414	3	10311562	10311562	CD
en-wikipedia-org-3485	414	4	.	.	.
en-wikipedia-org-3485	415	1	^	^	NNP
en-wikipedia-org-3485	415	2	Lammel	Lammel	NNP
en-wikipedia-org-3485	415	3	,	,	,
en-wikipedia-org-3485	415	4	S	S	NNP
en-wikipedia-org-3485	415	5	;	;	:
en-wikipedia-org-3485	415	6	Lim	Lim	NNP
en-wikipedia-org-3485	415	7	,	,	,
en-wikipedia-org-3485	415	8	BK	BK	NNP
en-wikipedia-org-3485	415	9	;	;	:
en-wikipedia-org-3485	415	10	Malenka	Malenka	NNP
en-wikipedia-org-3485	415	11	,	,	,
en-wikipedia-org-3485	415	12	RC	RC	NNP
en-wikipedia-org-3485	415	13	(	(	-LRB-
en-wikipedia-org-3485	415	14	January	January	NNP
en-wikipedia-org-3485	415	15	2014	2014	CD
en-wikipedia-org-3485	415	16	)	)	-RRB-
en-wikipedia-org-3485	415	17	.	.	.
en-wikipedia-org-3485	416	1	"	"	``
en-wikipedia-org-3485	416	2	Reward	reward	NN
en-wikipedia-org-3485	416	3	and	and	CC
en-wikipedia-org-3485	416	4	aversion	aversion	NN
en-wikipedia-org-3485	416	5	in	in	IN
en-wikipedia-org-3485	416	6	a	a	DT
en-wikipedia-org-3485	416	7	heterogeneous	heterogeneous	JJ
en-wikipedia-org-3485	416	8	midbrain	midbrain	NN
en-wikipedia-org-3485	416	9	dopamine	dopamine	NN
en-wikipedia-org-3485	416	10	system	system	NN
en-wikipedia-org-3485	416	11	"	"	''
en-wikipedia-org-3485	416	12	.	.	.
en-wikipedia-org-3485	417	1	Neuropharmacology	neuropharmacology	NN
en-wikipedia-org-3485	417	2	.	.	.
en-wikipedia-org-3485	418	1	76	76	CD
en-wikipedia-org-3485	418	2	Pt	Pt	NNP
en-wikipedia-org-3485	418	3	B	B	NNP
en-wikipedia-org-3485	418	4	:	:	:
en-wikipedia-org-3485	418	5	351–9	351–9	CD
en-wikipedia-org-3485	418	6	.	.	.
en-wikipedia-org-3485	419	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	419	2	/	/	SYM
en-wikipedia-org-3485	419	3	j.neuropharm.2013.03.019	j.neuropharm.2013.03.019	CD
en-wikipedia-org-3485	419	4	.	.	.
en-wikipedia-org-3485	420	1	PMC	PMC	NNP
en-wikipedia-org-3485	420	2	 	  	_SP
en-wikipedia-org-3485	420	3	3778102	3778102	CD
en-wikipedia-org-3485	420	4	.	.	.
en-wikipedia-org-3485	421	1	PMID	PMID	NNP
en-wikipedia-org-3485	421	2	 	  	_SP
en-wikipedia-org-3485	421	3	23578393	23578393	CD
en-wikipedia-org-3485	421	4	.	.	.
en-wikipedia-org-3485	422	1	^	^	NNP
en-wikipedia-org-3485	422	2	Nieh	Nieh	NNP
en-wikipedia-org-3485	422	3	,	,	,
en-wikipedia-org-3485	422	4	EH	EH	NNP
en-wikipedia-org-3485	422	5	;	;	:
en-wikipedia-org-3485	422	6	Kim	Kim	NNP
en-wikipedia-org-3485	422	7	,	,	,
en-wikipedia-org-3485	422	8	SY	SY	NNP
en-wikipedia-org-3485	422	9	;	;	:
en-wikipedia-org-3485	422	10	Namburi	Namburi	NNP
en-wikipedia-org-3485	422	11	,	,	,
en-wikipedia-org-3485	422	12	P	p	NN
en-wikipedia-org-3485	422	13	;	;	:
en-wikipedia-org-3485	422	14	Tye	Tye	NNP
en-wikipedia-org-3485	422	15	,	,	,
en-wikipedia-org-3485	422	16	KM	KM	NNP
en-wikipedia-org-3485	422	17	(	(	-LRB-
en-wikipedia-org-3485	422	18	20	20	CD
en-wikipedia-org-3485	422	19	May	May	NNP
en-wikipedia-org-3485	422	20	2013	2013	CD
en-wikipedia-org-3485	422	21	)	)	-RRB-
en-wikipedia-org-3485	422	22	.	.	.
en-wikipedia-org-3485	423	1	"	"	``
en-wikipedia-org-3485	423	2	Optogenetic	optogenetic	JJ
en-wikipedia-org-3485	423	3	dissection	dissection	NN
en-wikipedia-org-3485	423	4	of	of	IN
en-wikipedia-org-3485	423	5	neural	neural	JJ
en-wikipedia-org-3485	423	6	circuits	circuit	NNS
en-wikipedia-org-3485	423	7	underlying	underlie	VBG
en-wikipedia-org-3485	423	8	emotional	emotional	JJ
en-wikipedia-org-3485	423	9	valence	valence	NN
en-wikipedia-org-3485	423	10	and	and	CC
en-wikipedia-org-3485	423	11	motivated	motivated	JJ
en-wikipedia-org-3485	423	12	behaviors	behavior	NNS
en-wikipedia-org-3485	423	13	"	"	''
en-wikipedia-org-3485	423	14	.	.	.
en-wikipedia-org-3485	424	1	Brain	Brain	NNP
en-wikipedia-org-3485	424	2	Research	Research	NNP
en-wikipedia-org-3485	424	3	.	.	.
en-wikipedia-org-3485	425	1	1511	1511	CD
en-wikipedia-org-3485	425	2	:	:	:
en-wikipedia-org-3485	425	3	73–92	73–92	CD
en-wikipedia-org-3485	425	4	.	.	.
en-wikipedia-org-3485	426	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	426	2	/	/	SYM
en-wikipedia-org-3485	426	3	j.brainres.2012.11.001	j.brainres.2012.11.001	CD
en-wikipedia-org-3485	426	4	.	.	.
en-wikipedia-org-3485	427	1	hdl:1721.1/92890	hdl:1721.1/92890	NNP
en-wikipedia-org-3485	427	2	.	.	.
en-wikipedia-org-3485	428	1	PMC	PMC	NNP
en-wikipedia-org-3485	428	2	 	  	_SP
en-wikipedia-org-3485	428	3	4099056	4099056	CD
en-wikipedia-org-3485	428	4	.	.	.
en-wikipedia-org-3485	429	1	PMID	PMID	NNP
en-wikipedia-org-3485	429	2	 	  	_SP
en-wikipedia-org-3485	429	3	23142759	23142759	CD
en-wikipedia-org-3485	429	4	.	.	.
en-wikipedia-org-3485	430	1	^	^	NNP
en-wikipedia-org-3485	430	2	Trantham	Trantham	NNP
en-wikipedia-org-3485	430	3	-	-	HYPH
en-wikipedia-org-3485	430	4	Davidson	Davidson	NNP
en-wikipedia-org-3485	430	5	H	H	NNP
en-wikipedia-org-3485	430	6	,	,	,
en-wikipedia-org-3485	430	7	Neely	neely	RB
en-wikipedia-org-3485	430	8	LC	LC	NNP
en-wikipedia-org-3485	430	9	,	,	,
en-wikipedia-org-3485	430	10	Lavin	Lavin	NNP
en-wikipedia-org-3485	430	11	A	A	NNP
en-wikipedia-org-3485	430	12	,	,	,
en-wikipedia-org-3485	430	13	Seamans	Seamans	NNP
en-wikipedia-org-3485	430	14	JK	JK	NNP
en-wikipedia-org-3485	430	15	(	(	-LRB-
en-wikipedia-org-3485	430	16	2004	2004	CD
en-wikipedia-org-3485	430	17	)	)	-RRB-
en-wikipedia-org-3485	430	18	.	.	.
en-wikipedia-org-3485	431	1	"	"	``
en-wikipedia-org-3485	431	2	Mechanisms	Mechanisms	NNPS
en-wikipedia-org-3485	431	3	underlying	underlie	VBG
en-wikipedia-org-3485	431	4	differential	differential	NN
en-wikipedia-org-3485	431	5	D1	d1	NN
en-wikipedia-org-3485	431	6	versus	versus	IN
en-wikipedia-org-3485	431	7	D2	D2	NNP
en-wikipedia-org-3485	431	8	dopamine	dopamine	NN
en-wikipedia-org-3485	431	9	receptor	receptor	NN
en-wikipedia-org-3485	431	10	regulation	regulation	NN
en-wikipedia-org-3485	431	11	of	of	IN
en-wikipedia-org-3485	431	12	inhibition	inhibition	NN
en-wikipedia-org-3485	431	13	in	in	IN
en-wikipedia-org-3485	431	14	prefrontal	prefrontal	JJ
en-wikipedia-org-3485	431	15	cortex	cortex	NNP
en-wikipedia-org-3485	431	16	"	"	''
en-wikipedia-org-3485	431	17	.	.	.
en-wikipedia-org-3485	432	1	The	the	DT
en-wikipedia-org-3485	432	2	Journal	Journal	NNP
en-wikipedia-org-3485	432	3	of	of	IN
en-wikipedia-org-3485	432	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	432	5	.	.	.
en-wikipedia-org-3485	433	1	24	24	CD
en-wikipedia-org-3485	433	2	(	(	-LRB-
en-wikipedia-org-3485	433	3	47	47	CD
en-wikipedia-org-3485	433	4	)	)	-RRB-
en-wikipedia-org-3485	433	5	:	:	:
en-wikipedia-org-3485	433	6	10652–10659	10652–10659	CD
en-wikipedia-org-3485	433	7	.	.	.
en-wikipedia-org-3485	434	1	doi:10.1523	doi:10.1523	NNP
en-wikipedia-org-3485	434	2	/	/	SYM
en-wikipedia-org-3485	434	3	jneurosci.3179	jneurosci.3179	NNP
en-wikipedia-org-3485	434	4	-	-	HYPH
en-wikipedia-org-3485	434	5	04.2004	04.2004	CD
en-wikipedia-org-3485	434	6	.	.	.
en-wikipedia-org-3485	435	1	PMC	PMC	NNP
en-wikipedia-org-3485	435	2	 	  	_SP
en-wikipedia-org-3485	435	3	5509068	5509068	CD
en-wikipedia-org-3485	435	4	.	.	.
en-wikipedia-org-3485	436	1	PMID	PMID	NNP
en-wikipedia-org-3485	436	2	 	  	_SP
en-wikipedia-org-3485	436	3	15564581	15564581	CD
en-wikipedia-org-3485	436	4	.	.	.
en-wikipedia-org-3485	437	1	^	^	NFP
en-wikipedia-org-3485	437	2	You	-PRON-	PRP
en-wikipedia-org-3485	437	3	ZB	ZB	NNP
en-wikipedia-org-3485	437	4	,	,	,
en-wikipedia-org-3485	437	5	Chen	Chen	NNP
en-wikipedia-org-3485	437	6	YQ	YQ	NNP
en-wikipedia-org-3485	437	7	,	,	,
en-wikipedia-org-3485	437	8	Wise	Wise	NNP
en-wikipedia-org-3485	437	9	RA	RA	NNP
en-wikipedia-org-3485	437	10	(	(	-LRB-
en-wikipedia-org-3485	437	11	2001	2001	CD
en-wikipedia-org-3485	437	12	)	)	-RRB-
en-wikipedia-org-3485	437	13	.	.	.
en-wikipedia-org-3485	438	1	"	"	``
en-wikipedia-org-3485	438	2	Dopamine	dopamine	NN
en-wikipedia-org-3485	438	3	and	and	CC
en-wikipedia-org-3485	438	4	glutamate	glutamate	NN
en-wikipedia-org-3485	438	5	release	release	NN
en-wikipedia-org-3485	438	6	in	in	IN
en-wikipedia-org-3485	438	7	the	the	DT
en-wikipedia-org-3485	438	8	nucleus	nucleus	NN
en-wikipedia-org-3485	438	9	accumbens	accumben	NNS
en-wikipedia-org-3485	438	10	and	and	CC
en-wikipedia-org-3485	438	11	ventral	ventral	JJ
en-wikipedia-org-3485	438	12	tegmental	tegmental	JJ
en-wikipedia-org-3485	438	13	area	area	NN
en-wikipedia-org-3485	438	14	of	of	IN
en-wikipedia-org-3485	438	15	rat	rat	NN
en-wikipedia-org-3485	438	16	following	follow	VBG
en-wikipedia-org-3485	438	17	lateral	lateral	JJ
en-wikipedia-org-3485	438	18	hypothalamic	hypothalamic	JJ
en-wikipedia-org-3485	438	19	self	self	NN
en-wikipedia-org-3485	438	20	-	-	HYPH
en-wikipedia-org-3485	438	21	stimulation	stimulation	NN
en-wikipedia-org-3485	438	22	"	"	''
en-wikipedia-org-3485	438	23	.	.	.
en-wikipedia-org-3485	439	1	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	439	2	.	.	.
en-wikipedia-org-3485	440	1	107	107	CD
en-wikipedia-org-3485	440	2	(	(	-LRB-
en-wikipedia-org-3485	440	3	4	4	CD
en-wikipedia-org-3485	440	4	)	)	-RRB-
en-wikipedia-org-3485	440	5	:	:	:
en-wikipedia-org-3485	440	6	629–639	629–639	CD
en-wikipedia-org-3485	440	7	.	.	.
en-wikipedia-org-3485	441	1	doi:10.1016	doi:10.1016	JJ
en-wikipedia-org-3485	441	2	/	/	SYM
en-wikipedia-org-3485	441	3	s0306	s0306	NNP
en-wikipedia-org-3485	441	4	-	-	HYPH
en-wikipedia-org-3485	441	5	4522(01)00379	4522(01)00379	NNP
en-wikipedia-org-3485	441	6	-	-	HYPH
en-wikipedia-org-3485	441	7	7	7	CD
en-wikipedia-org-3485	441	8	.	.	.
en-wikipedia-org-3485	442	1	PMID	PMID	NNP
en-wikipedia-org-3485	442	2	 	  	_SP
en-wikipedia-org-3485	442	3	11720786	11720786	CD
en-wikipedia-org-3485	442	4	.	.	.
en-wikipedia-org-3485	443	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	443	2	 	  	_SP
en-wikipedia-org-3485	443	3	33615497	33615497	CD
en-wikipedia-org-3485	443	4	.	.	.
en-wikipedia-org-3485	444	1	^	^	NNP
en-wikipedia-org-3485	444	2	a	a	DT
en-wikipedia-org-3485	444	3	b	b	NNP
en-wikipedia-org-3485	444	4	Castro	Castro	NNP
en-wikipedia-org-3485	444	5	,	,	,
en-wikipedia-org-3485	444	6	DC	DC	NNP
en-wikipedia-org-3485	444	7	;	;	:
en-wikipedia-org-3485	444	8	Cole	Cole	NNP
en-wikipedia-org-3485	444	9	,	,	,
en-wikipedia-org-3485	444	10	SL	SL	NNP
en-wikipedia-org-3485	444	11	;	;	:
en-wikipedia-org-3485	444	12	Berridge	Berridge	NNP
en-wikipedia-org-3485	444	13	,	,	,
en-wikipedia-org-3485	444	14	KC	KC	NNP
en-wikipedia-org-3485	444	15	(	(	-LRB-
en-wikipedia-org-3485	444	16	2015	2015	CD
en-wikipedia-org-3485	444	17	)	)	-RRB-
en-wikipedia-org-3485	444	18	.	.	.
en-wikipedia-org-3485	445	1	"	"	``
en-wikipedia-org-3485	445	2	Lateral	lateral	JJ
en-wikipedia-org-3485	445	3	hypothalamus	hypothalamus	NN
en-wikipedia-org-3485	445	4	,	,	,
en-wikipedia-org-3485	445	5	nucleus	nucleus	NNP
en-wikipedia-org-3485	445	6	accumbens	accumbens	NNPS
en-wikipedia-org-3485	445	7	,	,	,
en-wikipedia-org-3485	445	8	and	and	CC
en-wikipedia-org-3485	445	9	ventral	ventral	JJ
en-wikipedia-org-3485	445	10	pallidum	pallidum	NN
en-wikipedia-org-3485	445	11	roles	role	NNS
en-wikipedia-org-3485	445	12	in	in	IN
en-wikipedia-org-3485	445	13	eating	eating	NN
en-wikipedia-org-3485	445	14	and	and	CC
en-wikipedia-org-3485	445	15	hunger	hunger	NN
en-wikipedia-org-3485	445	16	:	:	:
en-wikipedia-org-3485	445	17	interactions	interaction	NNS
en-wikipedia-org-3485	445	18	between	between	IN
en-wikipedia-org-3485	445	19	homeostatic	homeostatic	JJ
en-wikipedia-org-3485	445	20	and	and	CC
en-wikipedia-org-3485	445	21	reward	reward	NN
en-wikipedia-org-3485	445	22	circuitry	circuitry	NN
en-wikipedia-org-3485	445	23	"	"	''
en-wikipedia-org-3485	445	24	.	.	.
en-wikipedia-org-3485	446	1	Frontiers	frontier	NNS
en-wikipedia-org-3485	446	2	in	in	IN
en-wikipedia-org-3485	446	3	Systems	system	NNS
en-wikipedia-org-3485	446	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	446	5	.	.	.
en-wikipedia-org-3485	447	1	9	9	CD
en-wikipedia-org-3485	447	2	:	:	SYM
en-wikipedia-org-3485	447	3	90	90	CD
en-wikipedia-org-3485	447	4	.	.	.
en-wikipedia-org-3485	447	5	doi:10.3389	doi:10.3389	NNP
en-wikipedia-org-3485	447	6	/	/	SYM
en-wikipedia-org-3485	447	7	fnsys.2015.00090	fnsys.2015.00090	ADD
en-wikipedia-org-3485	447	8	.	.	.
en-wikipedia-org-3485	448	1	PMC	PMC	NNP
en-wikipedia-org-3485	448	2	 	  	_SP
en-wikipedia-org-3485	448	3	4466441	4466441	CD
en-wikipedia-org-3485	448	4	.	.	.
en-wikipedia-org-3485	449	1	PMID	PMID	NNP
en-wikipedia-org-3485	449	2	 	  	_SP
en-wikipedia-org-3485	449	3	26124708	26124708	CD
en-wikipedia-org-3485	449	4	.	.	.
en-wikipedia-org-3485	450	1	^	^	NFP
en-wikipedia-org-3485	450	2	Carlezon	Carlezon	NNP
en-wikipedia-org-3485	450	3	WA	WA	NNP
en-wikipedia-org-3485	450	4	,	,	,
en-wikipedia-org-3485	450	5	Jr	Jr	NNP
en-wikipedia-org-3485	450	6	;	;	:
en-wikipedia-org-3485	450	7	Thomas	Thomas	NNP
en-wikipedia-org-3485	450	8	,	,	,
en-wikipedia-org-3485	450	9	MJ	MJ	NNP
en-wikipedia-org-3485	450	10	(	(	-LRB-
en-wikipedia-org-3485	450	11	2009	2009	CD
en-wikipedia-org-3485	450	12	)	)	-RRB-
en-wikipedia-org-3485	450	13	.	.	.
en-wikipedia-org-3485	451	1	"	"	``
en-wikipedia-org-3485	451	2	Biological	biological	JJ
en-wikipedia-org-3485	451	3	substrates	substrate	NNS
en-wikipedia-org-3485	451	4	of	of	IN
en-wikipedia-org-3485	451	5	reward	reward	NN
en-wikipedia-org-3485	451	6	and	and	CC
en-wikipedia-org-3485	451	7	aversion	aversion	NN
en-wikipedia-org-3485	451	8	:	:	:
en-wikipedia-org-3485	451	9	a	a	DT
en-wikipedia-org-3485	451	10	nucleus	nucleus	NN
en-wikipedia-org-3485	451	11	accumbens	accumben	VBZ
en-wikipedia-org-3485	451	12	activity	activity	NN
en-wikipedia-org-3485	451	13	hypothesis	hypothesis	NN
en-wikipedia-org-3485	451	14	"	"	''
en-wikipedia-org-3485	451	15	.	.	.
en-wikipedia-org-3485	452	1	Neuropharmacology	neuropharmacology	NN
en-wikipedia-org-3485	452	2	.	.	.
en-wikipedia-org-3485	453	1	56	56	CD
en-wikipedia-org-3485	453	2	Suppl	Suppl	NNP
en-wikipedia-org-3485	453	3	1	1	CD
en-wikipedia-org-3485	453	4	:	:	SYM
en-wikipedia-org-3485	453	5	122–32	122–32	CD
en-wikipedia-org-3485	453	6	.	.	.
en-wikipedia-org-3485	454	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	454	2	/	/	SYM
en-wikipedia-org-3485	454	3	j.neuropharm.2008.06.075	j.neuropharm.2008.06.075	CD
en-wikipedia-org-3485	454	4	.	.	.
en-wikipedia-org-3485	455	1	PMC	PMC	NNP
en-wikipedia-org-3485	455	2	 	  	_SP
en-wikipedia-org-3485	455	3	2635333	2635333	CD
en-wikipedia-org-3485	455	4	.	.	.
en-wikipedia-org-3485	456	1	PMID	PMID	NNP
en-wikipedia-org-3485	456	2	 	  	_SP
en-wikipedia-org-3485	456	3	18675281	18675281	CD
en-wikipedia-org-3485	456	4	.	.	.
en-wikipedia-org-3485	457	1	^	^	NNP
en-wikipedia-org-3485	457	2	Wise	Wise	NNP
en-wikipedia-org-3485	457	3	RA	RA	NNP
en-wikipedia-org-3485	457	4	,	,	,
en-wikipedia-org-3485	457	5	Rompre	Rompre	NNP
en-wikipedia-org-3485	457	6	PP	PP	NNP
en-wikipedia-org-3485	457	7	(	(	-LRB-
en-wikipedia-org-3485	457	8	1989	1989	CD
en-wikipedia-org-3485	457	9	)	)	-RRB-
en-wikipedia-org-3485	457	10	.	.	.
en-wikipedia-org-3485	458	1	"	"	``
en-wikipedia-org-3485	458	2	Brain	brain	NN
en-wikipedia-org-3485	458	3	dopamine	dopamine	NN
en-wikipedia-org-3485	458	4	and	and	CC
en-wikipedia-org-3485	458	5	reward	reward	NN
en-wikipedia-org-3485	458	6	"	"	''
en-wikipedia-org-3485	458	7	.	.	.
en-wikipedia-org-3485	459	1	Annual	Annual	NNP
en-wikipedia-org-3485	459	2	Review	Review	NNP
en-wikipedia-org-3485	459	3	of	of	IN
en-wikipedia-org-3485	459	4	Psychology	Psychology	NNP
en-wikipedia-org-3485	459	5	.	.	.
en-wikipedia-org-3485	460	1	40	40	CD
en-wikipedia-org-3485	460	2	:	:	:
en-wikipedia-org-3485	460	3	191–225	191–225	CD
en-wikipedia-org-3485	460	4	.	.	.
en-wikipedia-org-3485	461	1	doi:10.1146	doi:10.1146	NNP
en-wikipedia-org-3485	461	2	/	/	SYM
en-wikipedia-org-3485	461	3	annurev.ps.40.020189.001203	annurev.ps.40.020189.001203	NN
en-wikipedia-org-3485	461	4	.	.	.
en-wikipedia-org-3485	462	1	PMID	PMID	NNP
en-wikipedia-org-3485	462	2	 	  	_SP
en-wikipedia-org-3485	462	3	2648975	2648975	CD
en-wikipedia-org-3485	462	4	.	.	.
en-wikipedia-org-3485	463	1	^	^	NFP
en-wikipedia-org-3485	463	2	Wise	Wise	NNP
en-wikipedia-org-3485	463	3	RA	RA	NNP
en-wikipedia-org-3485	463	4	(	(	-LRB-
en-wikipedia-org-3485	463	5	October	October	NNP
en-wikipedia-org-3485	463	6	2002	2002	CD
en-wikipedia-org-3485	463	7	)	)	-RRB-
en-wikipedia-org-3485	463	8	.	.	.
en-wikipedia-org-3485	464	1	"	"	``
en-wikipedia-org-3485	464	2	Brain	brain	NN
en-wikipedia-org-3485	464	3	reward	reward	NN
en-wikipedia-org-3485	464	4	circuitry	circuitry	NN
en-wikipedia-org-3485	464	5	:	:	:
en-wikipedia-org-3485	464	6	insights	insight	NNS
en-wikipedia-org-3485	464	7	from	from	IN
en-wikipedia-org-3485	464	8	unsensed	unsensed	JJ
en-wikipedia-org-3485	464	9	incentives	incentive	NNS
en-wikipedia-org-3485	464	10	"	"	''
en-wikipedia-org-3485	464	11	.	.	.
en-wikipedia-org-3485	465	1	Neuron	neuron	UH
en-wikipedia-org-3485	465	2	.	.	.
en-wikipedia-org-3485	466	1	36	36	CD
en-wikipedia-org-3485	466	2	(	(	-LRB-
en-wikipedia-org-3485	466	3	2	2	CD
en-wikipedia-org-3485	466	4	)	)	-RRB-
en-wikipedia-org-3485	466	5	:	:	:
en-wikipedia-org-3485	466	6	229–240	229–240	CD
en-wikipedia-org-3485	466	7	.	.	.
en-wikipedia-org-3485	467	1	doi:10.1016	doi:10.1016	JJ
en-wikipedia-org-3485	467	2	/	/	SYM
en-wikipedia-org-3485	467	3	S0896	S0896	NNP
en-wikipedia-org-3485	467	4	-	-	HYPH
en-wikipedia-org-3485	467	5	6273(02)00965	6273(02)00965	NNP
en-wikipedia-org-3485	467	6	-	-	HYPH
en-wikipedia-org-3485	467	7	0	0	NFP
en-wikipedia-org-3485	467	8	.	.	.
en-wikipedia-org-3485	468	1	PMID	PMID	NNP
en-wikipedia-org-3485	468	2	 	  	_SP
en-wikipedia-org-3485	468	3	12383779	12383779	CD
en-wikipedia-org-3485	468	4	.	.	.
en-wikipedia-org-3485	469	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	469	2	 	  	_SP
en-wikipedia-org-3485	469	3	16547037	16547037	CD
en-wikipedia-org-3485	469	4	.	.	.
en-wikipedia-org-3485	470	1	^	^	NNP
en-wikipedia-org-3485	470	2	https://youtube.com/NQBoNcr8qIk?t=788	https://youtube.com/NQBoNcr8qIk?t=788	NNP
en-wikipedia-org-3485	470	3	^	^	FW
en-wikipedia-org-3485	470	4	Kokane	Kokane	NNP
en-wikipedia-org-3485	470	5	,	,	,
en-wikipedia-org-3485	470	6	S.	S.	NNP
en-wikipedia-org-3485	470	7	S.	S.	NNP
en-wikipedia-org-3485	470	8	,	,	,
en-wikipedia-org-3485	470	9	&	&	CC
en-wikipedia-org-3485	470	10	Perrotti	Perrotti	NNP
en-wikipedia-org-3485	470	11	,	,	,
en-wikipedia-org-3485	470	12	L.	L.	NNP
en-wikipedia-org-3485	470	13	I.	I.	NNP
en-wikipedia-org-3485	471	1	(	(	-LRB-
en-wikipedia-org-3485	471	2	2020	2020	CD
en-wikipedia-org-3485	471	3	)	)	-RRB-
en-wikipedia-org-3485	471	4	.	.	.
en-wikipedia-org-3485	472	1	Sex	Sex	NNP
en-wikipedia-org-3485	472	2	Differences	Differences	NNP
en-wikipedia-org-3485	472	3	and	and	CC
en-wikipedia-org-3485	472	4	the	the	DT
en-wikipedia-org-3485	472	5	Role	role	NN
en-wikipedia-org-3485	472	6	of	of	IN
en-wikipedia-org-3485	472	7	Estradiol	Estradiol	NNP
en-wikipedia-org-3485	472	8	in	in	IN
en-wikipedia-org-3485	472	9	Mesolimbic	Mesolimbic	NNP
en-wikipedia-org-3485	472	10	Reward	Reward	NNP
en-wikipedia-org-3485	472	11	Circuits	Circuits	NNPS
en-wikipedia-org-3485	472	12	and	and	CC
en-wikipedia-org-3485	472	13	Vulnerability	Vulnerability	NNP
en-wikipedia-org-3485	472	14	to	to	IN
en-wikipedia-org-3485	472	15	Cocaine	Cocaine	NNP
en-wikipedia-org-3485	472	16	and	and	CC
en-wikipedia-org-3485	472	17	Opiate	Opiate	NNP
en-wikipedia-org-3485	472	18	Addiction	Addiction	NNP
en-wikipedia-org-3485	472	19	.	.	.
en-wikipedia-org-3485	473	1	Frontiers	frontier	NNS
en-wikipedia-org-3485	473	2	in	in	IN
en-wikipedia-org-3485	473	3	Behavioral	Behavioral	NNP
en-wikipedia-org-3485	473	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	473	5	,	,	,
en-wikipedia-org-3485	473	6	14	14	CD
en-wikipedia-org-3485	473	7	.	.	.
en-wikipedia-org-3485	474	1	^	^	NNP
en-wikipedia-org-3485	474	2	Becker	Becker	NNP
en-wikipedia-org-3485	474	3	,	,	,
en-wikipedia-org-3485	474	4	J.	J.	NNP
en-wikipedia-org-3485	475	1	B.	B.	NNP
en-wikipedia-org-3485	475	2	,	,	,
en-wikipedia-org-3485	475	3	&	&	CC
en-wikipedia-org-3485	475	4	Chartoff	Chartoff	NNP
en-wikipedia-org-3485	475	5	,	,	,
en-wikipedia-org-3485	475	6	E.	E.	NNP
en-wikipedia-org-3485	475	7	(	(	-LRB-
en-wikipedia-org-3485	475	8	2019	2019	CD
en-wikipedia-org-3485	475	9	)	)	-RRB-
en-wikipedia-org-3485	475	10	.	.	.
en-wikipedia-org-3485	476	1	Sex	sex	NN
en-wikipedia-org-3485	476	2	differences	difference	NNS
en-wikipedia-org-3485	476	3	in	in	IN
en-wikipedia-org-3485	476	4	neural	neural	JJ
en-wikipedia-org-3485	476	5	mechanisms	mechanism	NNS
en-wikipedia-org-3485	476	6	mediating	mediate	VBG
en-wikipedia-org-3485	476	7	reward	reward	NN
en-wikipedia-org-3485	476	8	and	and	CC
en-wikipedia-org-3485	476	9	addiction	addiction	NN
en-wikipedia-org-3485	476	10	.	.	.
en-wikipedia-org-3485	477	1	Neuropsychopharmacology	neuropsychopharmacology	NN
en-wikipedia-org-3485	477	2	,	,	,
en-wikipedia-org-3485	477	3	44(1	44(1	CD
en-wikipedia-org-3485	477	4	)	)	-RRB-
en-wikipedia-org-3485	477	5	,	,	,
en-wikipedia-org-3485	477	6	166	166	CD
en-wikipedia-org-3485	477	7	-	-	SYM
en-wikipedia-org-3485	477	8	183	183	CD
en-wikipedia-org-3485	477	9	.	.	.
en-wikipedia-org-3485	478	1	^	^	NNP
en-wikipedia-org-3485	478	2	Stoof	Stoof	NNP
en-wikipedia-org-3485	478	3	,	,	,
en-wikipedia-org-3485	478	4	J.	J.	NNP
en-wikipedia-org-3485	478	5	C.	C.	NNP
en-wikipedia-org-3485	478	6	,	,	,
en-wikipedia-org-3485	478	7	&	&	CC
en-wikipedia-org-3485	478	8	Kebabian	Kebabian	NNP
en-wikipedia-org-3485	478	9	,	,	,
en-wikipedia-org-3485	478	10	J.	J.	NNP
en-wikipedia-org-3485	478	11	W.	W.	NNP
en-wikipedia-org-3485	478	12	(	(	-LRB-
en-wikipedia-org-3485	478	13	1984	1984	CD
en-wikipedia-org-3485	478	14	)	)	-RRB-
en-wikipedia-org-3485	478	15	.	.	.
en-wikipedia-org-3485	479	1	Two	two	CD
en-wikipedia-org-3485	479	2	dopamine	dopamine	NN
en-wikipedia-org-3485	479	3	receptors	receptor	NNS
en-wikipedia-org-3485	479	4	:	:	:
en-wikipedia-org-3485	479	5	biochemistry	biochemistry	NN
en-wikipedia-org-3485	479	6	,	,	,
en-wikipedia-org-3485	479	7	physiology	physiology	NN
en-wikipedia-org-3485	479	8	and	and	CC
en-wikipedia-org-3485	479	9	pharmacology	pharmacology	NN
en-wikipedia-org-3485	479	10	.	.	.
en-wikipedia-org-3485	480	1	Life	Life	NNP
en-wikipedia-org-3485	480	2	sciences	science	NNS
en-wikipedia-org-3485	480	3	,	,	,
en-wikipedia-org-3485	480	4	35(23	35(23	CD
en-wikipedia-org-3485	480	5	)	)	-RRB-
en-wikipedia-org-3485	480	6	,	,	,
en-wikipedia-org-3485	480	7	2281	2281	CD
en-wikipedia-org-3485	480	8	-	-	SYM
en-wikipedia-org-3485	480	9	2296	2296	CD
en-wikipedia-org-3485	480	10	.	.	.
en-wikipedia-org-3485	481	1	^	^	NNP
en-wikipedia-org-3485	481	2	Kokane	Kokane	NNP
en-wikipedia-org-3485	481	3	,	,	,
en-wikipedia-org-3485	481	4	S.	S.	NNP
en-wikipedia-org-3485	481	5	S.	S.	NNP
en-wikipedia-org-3485	481	6	,	,	,
en-wikipedia-org-3485	481	7	&	&	CC
en-wikipedia-org-3485	481	8	Perrotti	Perrotti	NNP
en-wikipedia-org-3485	481	9	,	,	,
en-wikipedia-org-3485	481	10	L.	L.	NNP
en-wikipedia-org-3485	481	11	I.	I.	NNP
en-wikipedia-org-3485	482	1	(	(	-LRB-
en-wikipedia-org-3485	482	2	2020	2020	CD
en-wikipedia-org-3485	482	3	)	)	-RRB-
en-wikipedia-org-3485	482	4	.	.	.
en-wikipedia-org-3485	483	1	Sex	Sex	NNP
en-wikipedia-org-3485	483	2	Differences	Differences	NNP
en-wikipedia-org-3485	483	3	and	and	CC
en-wikipedia-org-3485	483	4	the	the	DT
en-wikipedia-org-3485	483	5	Role	role	NN
en-wikipedia-org-3485	483	6	of	of	IN
en-wikipedia-org-3485	483	7	Estradiol	Estradiol	NNP
en-wikipedia-org-3485	483	8	in	in	IN
en-wikipedia-org-3485	483	9	Mesolimbic	Mesolimbic	NNP
en-wikipedia-org-3485	483	10	Reward	Reward	NNP
en-wikipedia-org-3485	483	11	Circuits	Circuits	NNPS
en-wikipedia-org-3485	483	12	and	and	CC
en-wikipedia-org-3485	483	13	Vulnerability	Vulnerability	NNP
en-wikipedia-org-3485	483	14	to	to	IN
en-wikipedia-org-3485	483	15	Cocaine	Cocaine	NNP
en-wikipedia-org-3485	483	16	and	and	CC
en-wikipedia-org-3485	483	17	Opiate	Opiate	NNP
en-wikipedia-org-3485	483	18	Addiction	Addiction	NNP
en-wikipedia-org-3485	483	19	.	.	.
en-wikipedia-org-3485	484	1	Frontiers	frontier	NNS
en-wikipedia-org-3485	484	2	in	in	IN
en-wikipedia-org-3485	484	3	Behavioral	Behavioral	NNP
en-wikipedia-org-3485	484	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	484	5	,	,	,
en-wikipedia-org-3485	484	6	14	14	CD
en-wikipedia-org-3485	484	7	.	.	.
en-wikipedia-org-3485	485	1	^	^	NNP
en-wikipedia-org-3485	485	2	Yin	Yin	NNP
en-wikipedia-org-3485	485	3	,	,	,
en-wikipedia-org-3485	485	4	H.	H.	NNP
en-wikipedia-org-3485	485	5	H.	H.	NNP
en-wikipedia-org-3485	485	6	,	,	,
en-wikipedia-org-3485	485	7	Knowlton	Knowlton	NNP
en-wikipedia-org-3485	485	8	,	,	,
en-wikipedia-org-3485	485	9	B.	B.	NNP
en-wikipedia-org-3485	485	10	J.	J.	NNP
en-wikipedia-org-3485	485	11	,	,	,
en-wikipedia-org-3485	485	12	&	&	CC
en-wikipedia-org-3485	485	13	Balleine	Balleine	NNP
en-wikipedia-org-3485	485	14	,	,	,
en-wikipedia-org-3485	485	15	B.	B.	NNP
en-wikipedia-org-3485	485	16	W.	W.	NNP
en-wikipedia-org-3485	485	17	(	(	-LRB-
en-wikipedia-org-3485	485	18	2005	2005	CD
en-wikipedia-org-3485	485	19	)	)	-RRB-
en-wikipedia-org-3485	485	20	.	.	.
en-wikipedia-org-3485	486	1	Blockade	blockade	NN
en-wikipedia-org-3485	486	2	of	of	IN
en-wikipedia-org-3485	486	3	NMDA	NMDA	NNP
en-wikipedia-org-3485	486	4	receptors	receptor	NNS
en-wikipedia-org-3485	486	5	in	in	IN
en-wikipedia-org-3485	486	6	the	the	DT
en-wikipedia-org-3485	486	7	dorsomedial	dorsomedial	JJ
en-wikipedia-org-3485	486	8	striatum	striatum	NN
en-wikipedia-org-3485	486	9	prevents	prevent	VBZ
en-wikipedia-org-3485	486	10	action	action	NN
en-wikipedia-org-3485	486	11	–	–	:
en-wikipedia-org-3485	486	12	outcome	outcome	NN
en-wikipedia-org-3485	486	13	learning	learning	NN
en-wikipedia-org-3485	486	14	in	in	IN
en-wikipedia-org-3485	486	15	instrumental	instrumental	JJ
en-wikipedia-org-3485	486	16	conditioning	conditioning	NN
en-wikipedia-org-3485	486	17	.	.	.
en-wikipedia-org-3485	487	1	European	European	NNP
en-wikipedia-org-3485	487	2	Journal	Journal	NNP
en-wikipedia-org-3485	487	3	of	of	IN
en-wikipedia-org-3485	487	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	487	5	,	,	,
en-wikipedia-org-3485	487	6	22(2	22(2	CD
en-wikipedia-org-3485	487	7	)	)	-RRB-
en-wikipedia-org-3485	487	8	,	,	,
en-wikipedia-org-3485	487	9	505	505	CD
en-wikipedia-org-3485	487	10	-	-	SYM
en-wikipedia-org-3485	487	11	512	512	CD
en-wikipedia-org-3485	487	12	.	.	.
en-wikipedia-org-3485	488	1	^	^	NNP
en-wikipedia-org-3485	488	2	Koob	Koob	NNP
en-wikipedia-org-3485	488	3	,	,	,
en-wikipedia-org-3485	488	4	G.	G.	NNP
en-wikipedia-org-3485	488	5	F.	F.	NNP
en-wikipedia-org-3485	488	6	,	,	,
en-wikipedia-org-3485	488	7	&	&	CC
en-wikipedia-org-3485	488	8	Volkow	Volkow	NNP
en-wikipedia-org-3485	488	9	,	,	,
en-wikipedia-org-3485	488	10	N.	N.	NNP
en-wikipedia-org-3485	488	11	D.	D.	NNP
en-wikipedia-org-3485	488	12	(	(	-LRB-
en-wikipedia-org-3485	488	13	2016	2016	CD
en-wikipedia-org-3485	488	14	)	)	-RRB-
en-wikipedia-org-3485	488	15	.	.	.
en-wikipedia-org-3485	489	1	Neurobiology	neurobiology	NN
en-wikipedia-org-3485	489	2	of	of	IN
en-wikipedia-org-3485	489	3	addiction	addiction	NN
en-wikipedia-org-3485	489	4	:	:	:
en-wikipedia-org-3485	489	5	a	a	DT
en-wikipedia-org-3485	489	6	neurocircuitry	neurocircuitry	NN
en-wikipedia-org-3485	489	7	analysis	analysis	NN
en-wikipedia-org-3485	489	8	.	.	.
en-wikipedia-org-3485	490	1	The	the	DT
en-wikipedia-org-3485	490	2	Lancet	Lancet	NNP
en-wikipedia-org-3485	490	3	Psychiatry	Psychiatry	NNP
en-wikipedia-org-3485	490	4	,	,	,
en-wikipedia-org-3485	490	5	3(8	3(8	NNP
en-wikipedia-org-3485	490	6	)	)	-RRB-
en-wikipedia-org-3485	490	7	,	,	,
en-wikipedia-org-3485	490	8	760	760	CD
en-wikipedia-org-3485	490	9	-	-	SYM
en-wikipedia-org-3485	490	10	773	773	CD
en-wikipedia-org-3485	490	11	.	.	.
en-wikipedia-org-3485	491	1	^	^	NNP
en-wikipedia-org-3485	491	2	Koob	Koob	NNP
en-wikipedia-org-3485	491	3	,	,	,
en-wikipedia-org-3485	491	4	G.	G.	NNP
en-wikipedia-org-3485	491	5	F.	F.	NNP
en-wikipedia-org-3485	491	6	,	,	,
en-wikipedia-org-3485	491	7	&	&	CC
en-wikipedia-org-3485	491	8	Volkow	Volkow	NNP
en-wikipedia-org-3485	491	9	,	,	,
en-wikipedia-org-3485	491	10	N.	N.	NNP
en-wikipedia-org-3485	491	11	D.	D.	NNP
en-wikipedia-org-3485	491	12	(	(	-LRB-
en-wikipedia-org-3485	491	13	2016	2016	CD
en-wikipedia-org-3485	491	14	)	)	-RRB-
en-wikipedia-org-3485	491	15	.	.	.
en-wikipedia-org-3485	492	1	Neurobiology	neurobiology	NN
en-wikipedia-org-3485	492	2	of	of	IN
en-wikipedia-org-3485	492	3	addiction	addiction	NN
en-wikipedia-org-3485	492	4	:	:	:
en-wikipedia-org-3485	492	5	a	a	DT
en-wikipedia-org-3485	492	6	neurocircuitry	neurocircuitry	NN
en-wikipedia-org-3485	492	7	analysis	analysis	NN
en-wikipedia-org-3485	492	8	.	.	.
en-wikipedia-org-3485	493	1	The	the	DT
en-wikipedia-org-3485	493	2	Lancet	Lancet	NNP
en-wikipedia-org-3485	493	3	Psychiatry	Psychiatry	NNP
en-wikipedia-org-3485	493	4	,	,	,
en-wikipedia-org-3485	493	5	3(8	3(8	NNP
en-wikipedia-org-3485	493	6	)	)	-RRB-
en-wikipedia-org-3485	493	7	,	,	,
en-wikipedia-org-3485	493	8	760	760	CD
en-wikipedia-org-3485	493	9	-	-	SYM
en-wikipedia-org-3485	493	10	773	773	CD
en-wikipedia-org-3485	493	11	.	.	.
en-wikipedia-org-3485	494	1	^	^	NNP
en-wikipedia-org-3485	494	2	Koob	Koob	NNP
en-wikipedia-org-3485	494	3	,	,	,
en-wikipedia-org-3485	494	4	G.	G.	NNP
en-wikipedia-org-3485	494	5	F.	F.	NNP
en-wikipedia-org-3485	494	6	,	,	,
en-wikipedia-org-3485	494	7	&	&	CC
en-wikipedia-org-3485	494	8	Volkow	Volkow	NNP
en-wikipedia-org-3485	494	9	,	,	,
en-wikipedia-org-3485	494	10	N.	N.	NNP
en-wikipedia-org-3485	494	11	D.	D.	NNP
en-wikipedia-org-3485	494	12	(	(	-LRB-
en-wikipedia-org-3485	494	13	2016	2016	CD
en-wikipedia-org-3485	494	14	)	)	-RRB-
en-wikipedia-org-3485	494	15	.	.	.
en-wikipedia-org-3485	495	1	Neurobiology	neurobiology	NN
en-wikipedia-org-3485	495	2	of	of	IN
en-wikipedia-org-3485	495	3	addiction	addiction	NN
en-wikipedia-org-3485	495	4	:	:	:
en-wikipedia-org-3485	495	5	a	a	DT
en-wikipedia-org-3485	495	6	neurocircuitry	neurocircuitry	NN
en-wikipedia-org-3485	495	7	analysis	analysis	NN
en-wikipedia-org-3485	495	8	.	.	.
en-wikipedia-org-3485	496	1	The	the	DT
en-wikipedia-org-3485	496	2	Lancet	Lancet	NNP
en-wikipedia-org-3485	496	3	Psychiatry	Psychiatry	NNP
en-wikipedia-org-3485	496	4	,	,	,
en-wikipedia-org-3485	496	5	3(8	3(8	NNP
en-wikipedia-org-3485	496	6	)	)	-RRB-
en-wikipedia-org-3485	496	7	,	,	,
en-wikipedia-org-3485	496	8	760	760	CD
en-wikipedia-org-3485	496	9	-	-	SYM
en-wikipedia-org-3485	496	10	773	773	CD
en-wikipedia-org-3485	496	11	.	.	.
en-wikipedia-org-3485	497	1	^	^	NNP
en-wikipedia-org-3485	497	2	Kutlu	Kutlu	NNP
en-wikipedia-org-3485	497	3	,	,	,
en-wikipedia-org-3485	497	4	M.	M.	NNP
en-wikipedia-org-3485	497	5	G.	G.	NNP
en-wikipedia-org-3485	497	6	,	,	,
en-wikipedia-org-3485	497	7	&	&	CC
en-wikipedia-org-3485	497	8	Gould	Gould	NNP
en-wikipedia-org-3485	497	9	,	,	,
en-wikipedia-org-3485	497	10	T.	T.	NNP
en-wikipedia-org-3485	497	11	J.	J.	NNP
en-wikipedia-org-3485	498	1	(	(	-LRB-
en-wikipedia-org-3485	498	2	2016	2016	CD
en-wikipedia-org-3485	498	3	)	)	-RRB-
en-wikipedia-org-3485	498	4	.	.	.
en-wikipedia-org-3485	499	1	Effects	effect	NNS
en-wikipedia-org-3485	499	2	of	of	IN
en-wikipedia-org-3485	499	3	drugs	drug	NNS
en-wikipedia-org-3485	499	4	of	of	IN
en-wikipedia-org-3485	499	5	abuse	abuse	NN
en-wikipedia-org-3485	499	6	on	on	IN
en-wikipedia-org-3485	499	7	hippocampal	hippocampal	NNP
en-wikipedia-org-3485	499	8	plasticity	plasticity	NNP
en-wikipedia-org-3485	499	9	and	and	CC
en-wikipedia-org-3485	499	10	hippocampus	hippocampus	NN
en-wikipedia-org-3485	499	11	-	-	HYPH
en-wikipedia-org-3485	499	12	dependent	dependent	JJ
en-wikipedia-org-3485	499	13	learning	learning	NN
en-wikipedia-org-3485	499	14	and	and	CC
en-wikipedia-org-3485	499	15	memory	memory	NN
en-wikipedia-org-3485	499	16	:	:	:
en-wikipedia-org-3485	499	17	contributions	contribution	NNS
en-wikipedia-org-3485	499	18	to	to	IN
en-wikipedia-org-3485	499	19	development	development	NN
en-wikipedia-org-3485	499	20	and	and	CC
en-wikipedia-org-3485	499	21	maintenance	maintenance	NN
en-wikipedia-org-3485	499	22	of	of	IN
en-wikipedia-org-3485	499	23	addiction	addiction	NN
en-wikipedia-org-3485	499	24	.	.	.
en-wikipedia-org-3485	500	1	Learning	Learning	NNP
en-wikipedia-org-3485	500	2	&	&	CC
en-wikipedia-org-3485	500	3	memory	memory	NN
en-wikipedia-org-3485	500	4	,	,	,
en-wikipedia-org-3485	500	5	23(10	23(10	CD
en-wikipedia-org-3485	500	6	)	)	-RRB-
en-wikipedia-org-3485	500	7	,	,	,
en-wikipedia-org-3485	500	8	515	515	CD
en-wikipedia-org-3485	500	9	-	-	SYM
en-wikipedia-org-3485	500	10	533	533	CD
en-wikipedia-org-3485	500	11	.	.	.
en-wikipedia-org-3485	501	1	^	^	NNP
en-wikipedia-org-3485	501	2	McGaugh	McGaugh	NNP
en-wikipedia-org-3485	501	3	,	,	,
en-wikipedia-org-3485	501	4	J.	J.	NNP
en-wikipedia-org-3485	501	5	L.	L.	NNP
en-wikipedia-org-3485	501	6	(	(	-LRB-
en-wikipedia-org-3485	501	7	July	July	NNP
en-wikipedia-org-3485	501	8	2004	2004	CD
en-wikipedia-org-3485	501	9	)	)	-RRB-
en-wikipedia-org-3485	501	10	.	.	.
en-wikipedia-org-3485	502	1	"	"	``
en-wikipedia-org-3485	502	2	The	the	DT
en-wikipedia-org-3485	502	3	amygdala	amygdala	NN
en-wikipedia-org-3485	502	4	modulates	modulate	VBZ
en-wikipedia-org-3485	502	5	the	the	DT
en-wikipedia-org-3485	502	6	consolidation	consolidation	NN
en-wikipedia-org-3485	502	7	of	of	IN
en-wikipedia-org-3485	502	8	memories	memory	NNS
en-wikipedia-org-3485	502	9	of	of	IN
en-wikipedia-org-3485	502	10	emotionally	emotionally	RB
en-wikipedia-org-3485	502	11	arousing	arousing	JJ
en-wikipedia-org-3485	502	12	experiences	experience	NNS
en-wikipedia-org-3485	502	13	"	"	''
en-wikipedia-org-3485	502	14	.	.	.
en-wikipedia-org-3485	503	1	Annual	Annual	NNP
en-wikipedia-org-3485	503	2	Review	Review	NNP
en-wikipedia-org-3485	503	3	of	of	IN
en-wikipedia-org-3485	503	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	503	5	.	.	.
en-wikipedia-org-3485	504	1	27	27	CD
en-wikipedia-org-3485	504	2	(	(	-LRB-
en-wikipedia-org-3485	504	3	1	1	CD
en-wikipedia-org-3485	504	4	)	)	-RRB-
en-wikipedia-org-3485	504	5	:	:	:
en-wikipedia-org-3485	504	6	1–28	1–28	CD
en-wikipedia-org-3485	504	7	.	.	.
en-wikipedia-org-3485	505	1	^	^	NNP
en-wikipedia-org-3485	505	2	Koob	Koob	NNP
en-wikipedia-org-3485	505	3	G.	G.	NNP
en-wikipedia-org-3485	505	4	F.	F.	NNP
en-wikipedia-org-3485	505	5	,	,	,
en-wikipedia-org-3485	505	6	Le	Le	NNP
en-wikipedia-org-3485	505	7	Moal	Moal	NNP
en-wikipedia-org-3485	505	8	M.	M.	NNP
en-wikipedia-org-3485	505	9	(	(	-LRB-
en-wikipedia-org-3485	505	10	2008	2008	CD
en-wikipedia-org-3485	505	11	)	)	-RRB-
en-wikipedia-org-3485	505	12	.	.	.
en-wikipedia-org-3485	506	1	Addiction	addiction	NN
en-wikipedia-org-3485	506	2	and	and	CC
en-wikipedia-org-3485	506	3	the	the	DT
en-wikipedia-org-3485	506	4	brain	brain	NN
en-wikipedia-org-3485	506	5	antireward	antireward	NN
en-wikipedia-org-3485	506	6	system	system	NN
en-wikipedia-org-3485	506	7	.	.	.
en-wikipedia-org-3485	507	1	Annu	Annu	NNP
en-wikipedia-org-3485	507	2	.	.	.
en-wikipedia-org-3485	508	1	Rev.	Rev.	NNP
en-wikipedia-org-3485	509	1	Psychol	Psychol	NNP
en-wikipedia-org-3485	509	2	.	.	.
en-wikipedia-org-3485	510	1	59	59	CD
en-wikipedia-org-3485	510	2	29–53	29–53	CD
en-wikipedia-org-3485	510	3	.	.	.
en-wikipedia-org-3485	511	1	10.1146	10.1146	CD
en-wikipedia-org-3485	511	2	/	/	SYM
en-wikipedia-org-3485	511	3	annurev.psych.59.103006.093548	annurev.psych.59.103006.093548	NNP
en-wikipedia-org-3485	511	4	[	[	-LRB-
en-wikipedia-org-3485	511	5	PubMed	pubmed	NN
en-wikipedia-org-3485	511	6	]	]	-RRB-
en-wikipedia-org-3485	511	7	[	[	-LRB-
en-wikipedia-org-3485	511	8	CrossRef	CrossRef	NNP
en-wikipedia-org-3485	511	9	]	]	-RRB-
en-wikipedia-org-3485	511	10	[	[	-LRB-
en-wikipedia-org-3485	511	11	Google	Google	NNP
en-wikipedia-org-3485	511	12	Scholar	Scholar	NNP
en-wikipedia-org-3485	511	13	]	]	-RRB-
en-wikipedia-org-3485	511	14	Koob	Koob	NNP
en-wikipedia-org-3485	511	15	G.	G.	NNP
en-wikipedia-org-3485	511	16	F.	F.	NNP
en-wikipedia-org-3485	511	17	,	,	,
en-wikipedia-org-3485	511	18	Sanna	Sanna	NNP
en-wikipedia-org-3485	511	19	P.	P.	NNP
en-wikipedia-org-3485	511	20	P.	P.	NNP
en-wikipedia-org-3485	511	21	,	,	,
en-wikipedia-org-3485	511	22	Bloom	Bloom	NNP
en-wikipedia-org-3485	511	23	F.	F.	NNP
en-wikipedia-org-3485	511	24	E.	E.	NNP
en-wikipedia-org-3485	511	25	(	(	-LRB-
en-wikipedia-org-3485	511	26	1998	1998	CD
en-wikipedia-org-3485	511	27	)	)	-RRB-
en-wikipedia-org-3485	511	28	.	.	.
en-wikipedia-org-3485	512	1	Neuroscience	neuroscience	NN
en-wikipedia-org-3485	512	2	of	of	IN
en-wikipedia-org-3485	512	3	addiction	addiction	NN
en-wikipedia-org-3485	512	4	.	.	.
en-wikipedia-org-3485	513	1	Neuron	Neuron	NNP
en-wikipedia-org-3485	513	2	21	21	CD
en-wikipedia-org-3485	513	3	467–476	467–476	CD
en-wikipedia-org-3485	513	4	.	.	.
en-wikipedia-org-3485	514	1	^	^	NNP
en-wikipedia-org-3485	514	2	a	a	DT
en-wikipedia-org-3485	514	3	b	b	NNP
en-wikipedia-org-3485	514	4	c	c	NN
en-wikipedia-org-3485	514	5	Castro	Castro	NNP
en-wikipedia-org-3485	514	6	,	,	,
en-wikipedia-org-3485	514	7	DC	DC	NNP
en-wikipedia-org-3485	514	8	;	;	:
en-wikipedia-org-3485	514	9	Berridge	Berridge	NNP
en-wikipedia-org-3485	514	10	,	,	,
en-wikipedia-org-3485	514	11	KC	KC	NNP
en-wikipedia-org-3485	514	12	(	(	-LRB-
en-wikipedia-org-3485	514	13	24	24	CD
en-wikipedia-org-3485	514	14	October	October	NNP
en-wikipedia-org-3485	514	15	2017	2017	CD
en-wikipedia-org-3485	514	16	)	)	-RRB-
en-wikipedia-org-3485	514	17	.	.	.
en-wikipedia-org-3485	515	1	"	"	``
en-wikipedia-org-3485	515	2	Opioid	Opioid	NNP
en-wikipedia-org-3485	515	3	and	and	CC
en-wikipedia-org-3485	515	4	orexin	orexin	JJ
en-wikipedia-org-3485	515	5	hedonic	hedonic	JJ
en-wikipedia-org-3485	515	6	hotspots	hotspot	NNS
en-wikipedia-org-3485	515	7	in	in	IN
en-wikipedia-org-3485	515	8	rat	rat	NNP
en-wikipedia-org-3485	515	9	orbitofrontal	orbitofrontal	NNP
en-wikipedia-org-3485	515	10	cortex	cortex	NNP
en-wikipedia-org-3485	515	11	and	and	CC
en-wikipedia-org-3485	515	12	insula	insula	NNP
en-wikipedia-org-3485	515	13	"	"	''
en-wikipedia-org-3485	515	14	.	.	.
en-wikipedia-org-3485	516	1	Proceedings	proceeding	NNS
en-wikipedia-org-3485	516	2	of	of	IN
en-wikipedia-org-3485	516	3	the	the	DT
en-wikipedia-org-3485	516	4	National	National	NNP
en-wikipedia-org-3485	516	5	Academy	Academy	NNP
en-wikipedia-org-3485	516	6	of	of	IN
en-wikipedia-org-3485	516	7	Sciences	Sciences	NNPS
en-wikipedia-org-3485	516	8	of	of	IN
en-wikipedia-org-3485	516	9	the	the	DT
en-wikipedia-org-3485	516	10	United	United	NNP
en-wikipedia-org-3485	516	11	States	States	NNP
en-wikipedia-org-3485	516	12	of	of	IN
en-wikipedia-org-3485	516	13	America	America	NNP
en-wikipedia-org-3485	516	14	.	.	.
en-wikipedia-org-3485	517	1	114	114	CD
en-wikipedia-org-3485	517	2	(	(	-LRB-
en-wikipedia-org-3485	517	3	43	43	CD
en-wikipedia-org-3485	517	4	)	)	-RRB-
en-wikipedia-org-3485	517	5	:	:	:
en-wikipedia-org-3485	517	6	E9125–E9134	E9125–E9134	NNP
en-wikipedia-org-3485	517	7	.	.	.
en-wikipedia-org-3485	518	1	doi:10.1073	doi:10.1073	NNP
en-wikipedia-org-3485	518	2	/	/	SYM
en-wikipedia-org-3485	518	3	pnas.1705753114	pnas.1705753114	NNP
en-wikipedia-org-3485	518	4	.	.	.
en-wikipedia-org-3485	519	1	PMC	PMC	NNP
en-wikipedia-org-3485	519	2	 	  	_SP
en-wikipedia-org-3485	519	3	5664503	5664503	CD
en-wikipedia-org-3485	519	4	.	.	.
en-wikipedia-org-3485	520	1	PMID	PMID	NNP
en-wikipedia-org-3485	520	2	 	  	_SP
en-wikipedia-org-3485	520	3	29073109	29073109	CD
en-wikipedia-org-3485	520	4	.	.	.
en-wikipedia-org-3485	521	1	Here	here	RB
en-wikipedia-org-3485	521	2	,	,	,
en-wikipedia-org-3485	521	3	we	-PRON-	PRP
en-wikipedia-org-3485	521	4	show	show	VBP
en-wikipedia-org-3485	521	5	that	that	DT
en-wikipedia-org-3485	521	6	opioid	opioid	NN
en-wikipedia-org-3485	521	7	or	or	CC
en-wikipedia-org-3485	521	8	orexin	orexin	NN
en-wikipedia-org-3485	521	9	stimulations	stimulation	NNS
en-wikipedia-org-3485	521	10	in	in	IN
en-wikipedia-org-3485	521	11	orbitofrontal	orbitofrontal	JJ
en-wikipedia-org-3485	521	12	cortex	cortex	NNP
en-wikipedia-org-3485	521	13	and	and	CC
en-wikipedia-org-3485	521	14	insula	insula	NNP
en-wikipedia-org-3485	521	15	causally	causally	RB
en-wikipedia-org-3485	521	16	enhance	enhance	VB
en-wikipedia-org-3485	521	17	hedonic	hedonic	JJ
en-wikipedia-org-3485	521	18	“	"	``
en-wikipedia-org-3485	521	19	liking	like	VBG
en-wikipedia-org-3485	521	20	”	"	''
en-wikipedia-org-3485	521	21	reactions	reaction	NNS
en-wikipedia-org-3485	521	22	to	to	IN
en-wikipedia-org-3485	521	23	sweetness	sweetness	VB
en-wikipedia-org-3485	521	24	and	and	CC
en-wikipedia-org-3485	521	25	find	find	VB
en-wikipedia-org-3485	521	26	a	a	DT
en-wikipedia-org-3485	521	27	third	third	JJ
en-wikipedia-org-3485	521	28	cortical	cortical	JJ
en-wikipedia-org-3485	521	29	site	site	NN
en-wikipedia-org-3485	521	30	where	where	WRB
en-wikipedia-org-3485	521	31	the	the	DT
en-wikipedia-org-3485	521	32	same	same	JJ
en-wikipedia-org-3485	521	33	neurochemical	neurochemical	JJ
en-wikipedia-org-3485	521	34	stimulations	stimulation	NNS
en-wikipedia-org-3485	521	35	reduce	reduce	VBP
en-wikipedia-org-3485	521	36	positive	positive	JJ
en-wikipedia-org-3485	521	37	hedonic	hedonic	JJ
en-wikipedia-org-3485	521	38	impact	impact	NN
en-wikipedia-org-3485	521	39	.	.	.
en-wikipedia-org-3485	522	1	^	^	NNP
en-wikipedia-org-3485	522	2	Kringelbach	Kringelbach	NNP
en-wikipedia-org-3485	522	3	ML	ML	NNP
en-wikipedia-org-3485	522	4	,	,	,
en-wikipedia-org-3485	522	5	Berridge	Berridge	NNP
en-wikipedia-org-3485	522	6	KC	KC	NNP
en-wikipedia-org-3485	522	7	(	(	-LRB-
en-wikipedia-org-3485	522	8	2012	2012	CD
en-wikipedia-org-3485	522	9	)	)	-RRB-
en-wikipedia-org-3485	522	10	.	.	.
en-wikipedia-org-3485	523	1	"	"	``
en-wikipedia-org-3485	523	2	The	the	DT
en-wikipedia-org-3485	523	3	Joyful	joyful	JJ
en-wikipedia-org-3485	523	4	Mind	mind	NN
en-wikipedia-org-3485	523	5	"	"	''
en-wikipedia-org-3485	523	6	(	(	-LRB-
en-wikipedia-org-3485	523	7	PDF	PDF	NNP
en-wikipedia-org-3485	523	8	)	)	-RRB-
en-wikipedia-org-3485	523	9	.	.	.
en-wikipedia-org-3485	524	1	Scientific	scientific	JJ
en-wikipedia-org-3485	524	2	American	American	NNP
en-wikipedia-org-3485	524	3	.	.	.
en-wikipedia-org-3485	525	1	307	307	CD
en-wikipedia-org-3485	525	2	(	(	-LRB-
en-wikipedia-org-3485	525	3	2	2	CD
en-wikipedia-org-3485	525	4	)	)	-RRB-
en-wikipedia-org-3485	525	5	:	:	:
en-wikipedia-org-3485	525	6	44–45	44–45	CD
en-wikipedia-org-3485	525	7	.	.	.
en-wikipedia-org-3485	526	1	Bibcode:2012SciAm.307b	Bibcode:2012SciAm.307b	NNP
en-wikipedia-org-3485	526	2	..	..	NFP
en-wikipedia-org-3485	526	3	40K.	40k.	LS
en-wikipedia-org-3485	527	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-3485	527	2	/	/	SYM
en-wikipedia-org-3485	527	3	scientificamerican0812	scientificamerican0812	NNP
en-wikipedia-org-3485	527	4	-	-	HYPH
en-wikipedia-org-3485	527	5	40	40	CD
en-wikipedia-org-3485	527	6	.	.	.
en-wikipedia-org-3485	528	1	PMID	PMID	NNP
en-wikipedia-org-3485	528	2	 	  	_SP
en-wikipedia-org-3485	528	3	22844850	22844850	CD
en-wikipedia-org-3485	528	4	.	.	.
en-wikipedia-org-3485	529	1	Retrieved	retrieve	VBN
en-wikipedia-org-3485	529	2	17	17	CD
en-wikipedia-org-3485	529	3	January	January	NNP
en-wikipedia-org-3485	529	4	2017	2017	CD
en-wikipedia-org-3485	529	5	.	.	.
en-wikipedia-org-3485	530	1	So	so	CC
en-wikipedia-org-3485	530	2	it	-PRON-	PRP
en-wikipedia-org-3485	530	3	makes	make	VBZ
en-wikipedia-org-3485	530	4	sense	sense	NN
en-wikipedia-org-3485	530	5	that	that	IN
en-wikipedia-org-3485	530	6	the	the	DT
en-wikipedia-org-3485	530	7	real	real	JJ
en-wikipedia-org-3485	530	8	pleasure	pleasure	NN
en-wikipedia-org-3485	530	9	centers	center	NNS
en-wikipedia-org-3485	530	10	in	in	IN
en-wikipedia-org-3485	530	11	the	the	DT
en-wikipedia-org-3485	530	12	brain	brain	NN
en-wikipedia-org-3485	530	13	–	–	:
en-wikipedia-org-3485	530	14	those	those	DT
en-wikipedia-org-3485	530	15	directly	directly	RB
en-wikipedia-org-3485	530	16	responsible	responsible	JJ
en-wikipedia-org-3485	530	17	for	for	IN
en-wikipedia-org-3485	530	18	generating	generate	VBG
en-wikipedia-org-3485	530	19	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	530	20	sensations	sensation	NNS
en-wikipedia-org-3485	530	21	–	–	:
en-wikipedia-org-3485	530	22	turn	turn	VB
en-wikipedia-org-3485	530	23	out	out	RP
en-wikipedia-org-3485	530	24	to	to	TO
en-wikipedia-org-3485	530	25	lie	lie	VB
en-wikipedia-org-3485	530	26	within	within	IN
en-wikipedia-org-3485	530	27	some	some	DT
en-wikipedia-org-3485	530	28	of	of	IN
en-wikipedia-org-3485	530	29	the	the	DT
en-wikipedia-org-3485	530	30	structures	structure	NNS
en-wikipedia-org-3485	530	31	previously	previously	RB
en-wikipedia-org-3485	530	32	identified	identify	VBN
en-wikipedia-org-3485	530	33	as	as	IN
en-wikipedia-org-3485	530	34	part	part	NN
en-wikipedia-org-3485	530	35	of	of	IN
en-wikipedia-org-3485	530	36	the	the	DT
en-wikipedia-org-3485	530	37	reward	reward	NN
en-wikipedia-org-3485	530	38	circuit	circuit	NNP
en-wikipedia-org-3485	530	39	.	.	.
en-wikipedia-org-3485	531	1	One	one	CD
en-wikipedia-org-3485	531	2	of	of	IN
en-wikipedia-org-3485	531	3	these	these	DT
en-wikipedia-org-3485	531	4	so	so	RB
en-wikipedia-org-3485	531	5	-	-	HYPH
en-wikipedia-org-3485	531	6	called	call	VBN
en-wikipedia-org-3485	531	7	hedonic	hedonic	JJ
en-wikipedia-org-3485	531	8	hotspots	hotspot	NNS
en-wikipedia-org-3485	531	9	lies	lie	VBZ
en-wikipedia-org-3485	531	10	in	in	IN
en-wikipedia-org-3485	531	11	a	a	DT
en-wikipedia-org-3485	531	12	subregion	subregion	NN
en-wikipedia-org-3485	531	13	of	of	IN
en-wikipedia-org-3485	531	14	the	the	DT
en-wikipedia-org-3485	531	15	nucleus	nucleus	NN
en-wikipedia-org-3485	531	16	accumbens	accumben	NNS
en-wikipedia-org-3485	531	17	called	call	VBD
en-wikipedia-org-3485	531	18	the	the	DT
en-wikipedia-org-3485	531	19	medial	medial	NNP
en-wikipedia-org-3485	531	20	shell	shell	NN
en-wikipedia-org-3485	531	21	.	.	.
en-wikipedia-org-3485	532	1	A	a	DT
en-wikipedia-org-3485	532	2	second	second	JJ
en-wikipedia-org-3485	532	3	is	be	VBZ
en-wikipedia-org-3485	532	4	found	find	VBN
en-wikipedia-org-3485	532	5	within	within	IN
en-wikipedia-org-3485	532	6	the	the	DT
en-wikipedia-org-3485	532	7	ventral	ventral	JJ
en-wikipedia-org-3485	532	8	pallidum	pallidum	NN
en-wikipedia-org-3485	532	9	,	,	,
en-wikipedia-org-3485	532	10	a	a	DT
en-wikipedia-org-3485	532	11	deep	deep	RB
en-wikipedia-org-3485	532	12	-	-	HYPH
en-wikipedia-org-3485	532	13	seated	seat	VBN
en-wikipedia-org-3485	532	14	structure	structure	NN
en-wikipedia-org-3485	532	15	near	near	IN
en-wikipedia-org-3485	532	16	the	the	DT
en-wikipedia-org-3485	532	17	base	base	NN
en-wikipedia-org-3485	532	18	of	of	IN
en-wikipedia-org-3485	532	19	the	the	DT
en-wikipedia-org-3485	532	20	forebrain	forebrain	NN
en-wikipedia-org-3485	532	21	that	that	WDT
en-wikipedia-org-3485	532	22	receives	receive	VBZ
en-wikipedia-org-3485	532	23	most	most	JJS
en-wikipedia-org-3485	532	24	of	of	IN
en-wikipedia-org-3485	532	25	its	-PRON-	PRP$
en-wikipedia-org-3485	532	26	signals	signal	NNS
en-wikipedia-org-3485	532	27	from	from	IN
en-wikipedia-org-3485	532	28	the	the	DT
en-wikipedia-org-3485	532	29	nucleus	nucleus	NN
en-wikipedia-org-3485	532	30	accumbens	accumben	NNS
en-wikipedia-org-3485	532	31	.	.	.
en-wikipedia-org-3485	533	1	...	...	:
en-wikipedia-org-3485	533	2	     	     	_SP
en-wikipedia-org-3485	533	3	On	on	IN
en-wikipedia-org-3485	533	4	the	the	DT
en-wikipedia-org-3485	533	5	other	other	JJ
en-wikipedia-org-3485	533	6	hand	hand	NN
en-wikipedia-org-3485	533	7	,	,	,
en-wikipedia-org-3485	533	8	intense	intense	JJ
en-wikipedia-org-3485	533	9	euphoria	euphoria	NN
en-wikipedia-org-3485	533	10	is	be	VBZ
en-wikipedia-org-3485	533	11	harder	hard	JJR
en-wikipedia-org-3485	533	12	to	to	TO
en-wikipedia-org-3485	533	13	come	come	VB
en-wikipedia-org-3485	533	14	by	by	RB
en-wikipedia-org-3485	533	15	than	than	IN
en-wikipedia-org-3485	533	16	everyday	everyday	JJ
en-wikipedia-org-3485	533	17	pleasures	pleasure	NNS
en-wikipedia-org-3485	533	18	.	.	.
en-wikipedia-org-3485	534	1	The	the	DT
en-wikipedia-org-3485	534	2	reason	reason	NN
en-wikipedia-org-3485	534	3	may	may	MD
en-wikipedia-org-3485	534	4	be	be	VB
en-wikipedia-org-3485	534	5	that	that	DT
en-wikipedia-org-3485	534	6	strong	strong	JJ
en-wikipedia-org-3485	534	7	enhancement	enhancement	NN
en-wikipedia-org-3485	534	8	of	of	IN
en-wikipedia-org-3485	534	9	pleasure	pleasure	NN
en-wikipedia-org-3485	534	10	–	–	:
en-wikipedia-org-3485	534	11	like	like	IN
en-wikipedia-org-3485	534	12	the	the	DT
en-wikipedia-org-3485	534	13	chemically	chemically	RB
en-wikipedia-org-3485	534	14	induced	induce	VBN
en-wikipedia-org-3485	534	15	pleasure	pleasure	NN
en-wikipedia-org-3485	534	16	bump	bump	NN
en-wikipedia-org-3485	534	17	we	-PRON-	PRP
en-wikipedia-org-3485	534	18	produced	produce	VBD
en-wikipedia-org-3485	534	19	in	in	IN
en-wikipedia-org-3485	534	20	lab	lab	NN
en-wikipedia-org-3485	534	21	animals	animal	NNS
en-wikipedia-org-3485	534	22	–	–	:
en-wikipedia-org-3485	534	23	seems	seem	VBZ
en-wikipedia-org-3485	534	24	to	to	TO
en-wikipedia-org-3485	534	25	require	require	VB
en-wikipedia-org-3485	534	26	activation	activation	NN
en-wikipedia-org-3485	534	27	of	of	IN
en-wikipedia-org-3485	534	28	the	the	DT
en-wikipedia-org-3485	534	29	entire	entire	JJ
en-wikipedia-org-3485	534	30	network	network	NN
en-wikipedia-org-3485	534	31	at	at	IN
en-wikipedia-org-3485	534	32	once	once	RB
en-wikipedia-org-3485	534	33	.	.	.
en-wikipedia-org-3485	535	1	Defection	defection	NN
en-wikipedia-org-3485	535	2	of	of	IN
en-wikipedia-org-3485	535	3	any	any	DT
en-wikipedia-org-3485	535	4	single	single	JJ
en-wikipedia-org-3485	535	5	component	component	NN
en-wikipedia-org-3485	535	6	dampens	dampen	VBZ
en-wikipedia-org-3485	535	7	the	the	DT
en-wikipedia-org-3485	535	8	high	high	JJ
en-wikipedia-org-3485	535	9	.	.	.
en-wikipedia-org-3485	536	1	Whether	whether	IN
en-wikipedia-org-3485	536	2	the	the	DT
en-wikipedia-org-3485	536	3	pleasure	pleasure	NN
en-wikipedia-org-3485	536	4	circuit	circuit	NN
en-wikipedia-org-3485	536	5	–	–	:
en-wikipedia-org-3485	536	6	and	and	CC
en-wikipedia-org-3485	536	7	in	in	IN
en-wikipedia-org-3485	536	8	particular	particular	JJ
en-wikipedia-org-3485	536	9	,	,	,
en-wikipedia-org-3485	536	10	the	the	DT
en-wikipedia-org-3485	536	11	ventral	ventral	JJ
en-wikipedia-org-3485	536	12	pallidum	pallidum	NN
en-wikipedia-org-3485	536	13	–	–	:
en-wikipedia-org-3485	536	14	works	work	VBZ
en-wikipedia-org-3485	536	15	the	the	DT
en-wikipedia-org-3485	536	16	same	same	JJ
en-wikipedia-org-3485	536	17	way	way	NN
en-wikipedia-org-3485	536	18	in	in	IN
en-wikipedia-org-3485	536	19	humans	human	NNS
en-wikipedia-org-3485	536	20	is	be	VBZ
en-wikipedia-org-3485	536	21	unclear	unclear	JJ
en-wikipedia-org-3485	536	22	.	.	.
en-wikipedia-org-3485	537	1	^	^	NNP
en-wikipedia-org-3485	537	2	a	a	DT
en-wikipedia-org-3485	537	3	b	b	NNP
en-wikipedia-org-3485	537	4	Berridge	Berridge	NNP
en-wikipedia-org-3485	537	5	KC	KC	NNP
en-wikipedia-org-3485	537	6	(	(	-LRB-
en-wikipedia-org-3485	537	7	April	April	NNP
en-wikipedia-org-3485	537	8	2012	2012	CD
en-wikipedia-org-3485	537	9	)	)	-RRB-
en-wikipedia-org-3485	537	10	.	.	.
en-wikipedia-org-3485	538	1	"	"	``
en-wikipedia-org-3485	538	2	From	from	IN
en-wikipedia-org-3485	538	3	prediction	prediction	NN
en-wikipedia-org-3485	538	4	error	error	NN
en-wikipedia-org-3485	538	5	to	to	TO
en-wikipedia-org-3485	538	6	incentive	incentive	VB
en-wikipedia-org-3485	538	7	salience	salience	NN
en-wikipedia-org-3485	538	8	:	:	:
en-wikipedia-org-3485	538	9	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	538	10	computation	computation	NN
en-wikipedia-org-3485	538	11	of	of	IN
en-wikipedia-org-3485	538	12	reward	reward	NN
en-wikipedia-org-3485	538	13	motivation	motivation	NN
en-wikipedia-org-3485	538	14	"	"	''
en-wikipedia-org-3485	538	15	.	.	.
en-wikipedia-org-3485	539	1	Eur	Eur	NNP
en-wikipedia-org-3485	539	2	.	.	.
en-wikipedia-org-3485	540	1	J.	J.	NNP
en-wikipedia-org-3485	540	2	Neurosci	Neurosci	NNP
en-wikipedia-org-3485	540	3	.	.	.
en-wikipedia-org-3485	541	1	35	35	CD
en-wikipedia-org-3485	541	2	(	(	-LRB-
en-wikipedia-org-3485	541	3	7	7	CD
en-wikipedia-org-3485	541	4	)	)	-RRB-
en-wikipedia-org-3485	541	5	:	:	:
en-wikipedia-org-3485	541	6	1124–1143	1124–1143	CD
en-wikipedia-org-3485	541	7	.	.	.
en-wikipedia-org-3485	542	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-3485	542	2	/	/	SYM
en-wikipedia-org-3485	542	3	j.1460	j.1460	NNP
en-wikipedia-org-3485	542	4	-	-	HYPH
en-wikipedia-org-3485	542	5	9568.2012.07990.x	9568.2012.07990.x	CD
en-wikipedia-org-3485	542	6	.	.	.
en-wikipedia-org-3485	543	1	PMC	PMC	NNP
en-wikipedia-org-3485	543	2	 	  	_SP
en-wikipedia-org-3485	543	3	3325516	3325516	CD
en-wikipedia-org-3485	543	4	.	.	.
en-wikipedia-org-3485	544	1	PMID	PMID	NNP
en-wikipedia-org-3485	544	2	 	  	_SP
en-wikipedia-org-3485	544	3	22487042	22487042	CD
en-wikipedia-org-3485	544	4	.	.	.
en-wikipedia-org-3485	545	1	Here	here	RB
en-wikipedia-org-3485	545	2	I	-PRON-	PRP
en-wikipedia-org-3485	545	3	discuss	discuss	VBP
en-wikipedia-org-3485	545	4	how	how	WRB
en-wikipedia-org-3485	545	5	mesocorticolimbic	mesocorticolimbic	JJ
en-wikipedia-org-3485	545	6	mechanisms	mechanism	NNS
en-wikipedia-org-3485	545	7	generate	generate	VBP
en-wikipedia-org-3485	545	8	the	the	DT
en-wikipedia-org-3485	545	9	motivation	motivation	NN
en-wikipedia-org-3485	545	10	component	component	NN
en-wikipedia-org-3485	545	11	of	of	IN
en-wikipedia-org-3485	545	12	incentive	incentive	NN
en-wikipedia-org-3485	545	13	salience	salience	NN
en-wikipedia-org-3485	545	14	.	.	.
en-wikipedia-org-3485	546	1	Incentive	incentive	JJ
en-wikipedia-org-3485	546	2	salience	salience	NN
en-wikipedia-org-3485	546	3	takes	take	VBZ
en-wikipedia-org-3485	546	4	Pavlovian	pavlovian	JJ
en-wikipedia-org-3485	546	5	learning	learning	NN
en-wikipedia-org-3485	546	6	and	and	CC
en-wikipedia-org-3485	546	7	memory	memory	NN
en-wikipedia-org-3485	546	8	as	as	IN
en-wikipedia-org-3485	546	9	one	one	CD
en-wikipedia-org-3485	546	10	input	input	NN
en-wikipedia-org-3485	546	11	and	and	CC
en-wikipedia-org-3485	546	12	as	as	IN
en-wikipedia-org-3485	546	13	an	an	DT
en-wikipedia-org-3485	546	14	equally	equally	RB
en-wikipedia-org-3485	546	15	important	important	JJ
en-wikipedia-org-3485	546	16	input	input	NN
en-wikipedia-org-3485	546	17	takes	take	VBZ
en-wikipedia-org-3485	546	18	neurobiological	neurobiological	JJ
en-wikipedia-org-3485	546	19	state	state	NN
en-wikipedia-org-3485	546	20	factors	factor	NNS
en-wikipedia-org-3485	546	21	(	(	-LRB-
en-wikipedia-org-3485	546	22	e.g.	e.g.	RB
en-wikipedia-org-3485	547	1	drug	drug	NNP
en-wikipedia-org-3485	547	2	states	state	NNS
en-wikipedia-org-3485	547	3	,	,	,
en-wikipedia-org-3485	547	4	appetite	appetite	NNP
en-wikipedia-org-3485	547	5	states	state	NNS
en-wikipedia-org-3485	547	6	,	,	,
en-wikipedia-org-3485	547	7	satiety	satiety	NNP
en-wikipedia-org-3485	547	8	states	state	NNS
en-wikipedia-org-3485	547	9	)	)	-RRB-
en-wikipedia-org-3485	547	10	that	that	WDT
en-wikipedia-org-3485	547	11	can	can	MD
en-wikipedia-org-3485	547	12	vary	vary	VB
en-wikipedia-org-3485	547	13	independently	independently	RB
en-wikipedia-org-3485	547	14	of	of	IN
en-wikipedia-org-3485	547	15	learning	learn	VBG
en-wikipedia-org-3485	547	16	.	.	.
en-wikipedia-org-3485	548	1	Neurobiological	neurobiological	JJ
en-wikipedia-org-3485	548	2	state	state	NN
en-wikipedia-org-3485	548	3	changes	change	NNS
en-wikipedia-org-3485	548	4	can	can	MD
en-wikipedia-org-3485	548	5	produce	produce	VB
en-wikipedia-org-3485	548	6	unlearned	unlearned	JJ
en-wikipedia-org-3485	548	7	fluctuations	fluctuation	NNS
en-wikipedia-org-3485	548	8	or	or	CC
en-wikipedia-org-3485	548	9	even	even	RB
en-wikipedia-org-3485	548	10	reversals	reversal	NNS
en-wikipedia-org-3485	548	11	in	in	IN
en-wikipedia-org-3485	548	12	the	the	DT
en-wikipedia-org-3485	548	13	ability	ability	NN
en-wikipedia-org-3485	548	14	of	of	IN
en-wikipedia-org-3485	548	15	a	a	DT
en-wikipedia-org-3485	548	16	previously	previously	RB
en-wikipedia-org-3485	548	17	learned	learn	VBN
en-wikipedia-org-3485	548	18	reward	reward	NN
en-wikipedia-org-3485	548	19	cue	cue	NN
en-wikipedia-org-3485	548	20	to	to	TO
en-wikipedia-org-3485	548	21	trigger	trigger	VB
en-wikipedia-org-3485	548	22	motivation	motivation	NN
en-wikipedia-org-3485	548	23	.	.	.
en-wikipedia-org-3485	549	1	Such	such	JJ
en-wikipedia-org-3485	549	2	fluctuations	fluctuation	NNS
en-wikipedia-org-3485	549	3	in	in	IN
en-wikipedia-org-3485	549	4	cue	cue	NN
en-wikipedia-org-3485	549	5	-	-	HYPH
en-wikipedia-org-3485	549	6	triggered	trigger	VBN
en-wikipedia-org-3485	549	7	motivation	motivation	NN
en-wikipedia-org-3485	549	8	can	can	MD
en-wikipedia-org-3485	549	9	dramatically	dramatically	RB
en-wikipedia-org-3485	549	10	depart	depart	VB
en-wikipedia-org-3485	549	11	from	from	IN
en-wikipedia-org-3485	549	12	all	all	DT
en-wikipedia-org-3485	549	13	previously	previously	RB
en-wikipedia-org-3485	549	14	learned	learn	VBN
en-wikipedia-org-3485	549	15	values	value	NNS
en-wikipedia-org-3485	549	16	about	about	IN
en-wikipedia-org-3485	549	17	the	the	DT
en-wikipedia-org-3485	549	18	associated	associated	NNP
en-wikipedia-org-3485	549	19	reward	reward	NNP
en-wikipedia-org-3485	549	20	outcome	outcome	NNP
en-wikipedia-org-3485	549	21	.	.	.
en-wikipedia-org-3485	550	1	...	...	:
en-wikipedia-org-3485	550	2	Associative	associative	JJ
en-wikipedia-org-3485	550	3	learning	learning	NN
en-wikipedia-org-3485	550	4	and	and	CC
en-wikipedia-org-3485	550	5	prediction	prediction	NN
en-wikipedia-org-3485	550	6	are	be	VBP
en-wikipedia-org-3485	550	7	important	important	JJ
en-wikipedia-org-3485	550	8	contributors	contributor	NNS
en-wikipedia-org-3485	550	9	to	to	IN
en-wikipedia-org-3485	550	10	motivation	motivation	NN
en-wikipedia-org-3485	550	11	for	for	IN
en-wikipedia-org-3485	550	12	rewards	reward	NNS
en-wikipedia-org-3485	550	13	.	.	.
en-wikipedia-org-3485	551	1	Learning	learning	NN
en-wikipedia-org-3485	551	2	gives	give	VBZ
en-wikipedia-org-3485	551	3	incentive	incentive	NN
en-wikipedia-org-3485	551	4	value	value	NN
en-wikipedia-org-3485	551	5	to	to	IN
en-wikipedia-org-3485	551	6	arbitrary	arbitrary	JJ
en-wikipedia-org-3485	551	7	cues	cue	NNS
en-wikipedia-org-3485	551	8	such	such	JJ
en-wikipedia-org-3485	551	9	as	as	IN
en-wikipedia-org-3485	551	10	a	a	DT
en-wikipedia-org-3485	551	11	Pavlovian	Pavlovian	NNP
en-wikipedia-org-3485	551	12	conditioned	condition	VBN
en-wikipedia-org-3485	551	13	stimulus	stimulus	NN
en-wikipedia-org-3485	551	14	(	(	-LRB-
en-wikipedia-org-3485	551	15	CS	CS	NNP
en-wikipedia-org-3485	551	16	)	)	-RRB-
en-wikipedia-org-3485	551	17	that	that	WDT
en-wikipedia-org-3485	551	18	is	be	VBZ
en-wikipedia-org-3485	551	19	associated	associate	VBN
en-wikipedia-org-3485	551	20	with	with	IN
en-wikipedia-org-3485	551	21	a	a	DT
en-wikipedia-org-3485	551	22	reward	reward	NN
en-wikipedia-org-3485	551	23	(	(	-LRB-
en-wikipedia-org-3485	551	24	unconditioned	unconditioned	JJ
en-wikipedia-org-3485	551	25	stimulus	stimulus	NN
en-wikipedia-org-3485	551	26	or	or	CC
en-wikipedia-org-3485	551	27	UCS	UCS	NNP
en-wikipedia-org-3485	551	28	)	)	-RRB-
en-wikipedia-org-3485	551	29	.	.	.
en-wikipedia-org-3485	552	1	Learned	learn	VBN
en-wikipedia-org-3485	552	2	cues	cue	NNS
en-wikipedia-org-3485	552	3	for	for	IN
en-wikipedia-org-3485	552	4	reward	reward	NN
en-wikipedia-org-3485	552	5	are	be	VBP
en-wikipedia-org-3485	552	6	often	often	RB
en-wikipedia-org-3485	552	7	potent	potent	JJ
en-wikipedia-org-3485	552	8	triggers	trigger	NNS
en-wikipedia-org-3485	552	9	of	of	IN
en-wikipedia-org-3485	552	10	desires	desire	NNS
en-wikipedia-org-3485	552	11	.	.	.
en-wikipedia-org-3485	553	1	For	for	IN
en-wikipedia-org-3485	553	2	example	example	NN
en-wikipedia-org-3485	553	3	,	,	,
en-wikipedia-org-3485	553	4	learned	learn	VBN
en-wikipedia-org-3485	553	5	cues	cue	NNS
en-wikipedia-org-3485	553	6	can	can	MD
en-wikipedia-org-3485	553	7	trigger	trigger	VB
en-wikipedia-org-3485	553	8	normal	normal	JJ
en-wikipedia-org-3485	553	9	appetites	appetite	NNS
en-wikipedia-org-3485	553	10	in	in	IN
en-wikipedia-org-3485	553	11	everyone	everyone	NN
en-wikipedia-org-3485	553	12	,	,	,
en-wikipedia-org-3485	553	13	and	and	CC
en-wikipedia-org-3485	553	14	can	can	MD
en-wikipedia-org-3485	553	15	sometimes	sometimes	RB
en-wikipedia-org-3485	553	16	trigger	trigger	VB
en-wikipedia-org-3485	553	17	compulsive	compulsive	JJ
en-wikipedia-org-3485	553	18	urges	urge	NNS
en-wikipedia-org-3485	553	19	and	and	CC
en-wikipedia-org-3485	553	20	relapse	relapse	VBP
en-wikipedia-org-3485	553	21	in	in	IN
en-wikipedia-org-3485	553	22	addicts	addict	NNS
en-wikipedia-org-3485	553	23	.	.	.
en-wikipedia-org-3485	554	1	Cue	Cue	NNP
en-wikipedia-org-3485	554	2	-	-	HYPH
en-wikipedia-org-3485	554	3	triggered	trigger	VBN
en-wikipedia-org-3485	554	4	'	'	''
en-wikipedia-org-3485	554	5	wanting	want	VBG
en-wikipedia-org-3485	554	6	’	'	''
en-wikipedia-org-3485	554	7	for	for	IN
en-wikipedia-org-3485	554	8	the	the	DT
en-wikipedia-org-3485	554	9	UCS	UCS	NNP
en-wikipedia-org-3485	554	10	A	a	DT
en-wikipedia-org-3485	554	11	brief	brief	JJ
en-wikipedia-org-3485	554	12	CS	CS	NNP
en-wikipedia-org-3485	554	13	encounter	encounter	NN
en-wikipedia-org-3485	554	14	(	(	-LRB-
en-wikipedia-org-3485	554	15	or	or	CC
en-wikipedia-org-3485	554	16	brief	brief	JJ
en-wikipedia-org-3485	554	17	UCS	UCS	NNP
en-wikipedia-org-3485	554	18	encounter	encounter	NN
en-wikipedia-org-3485	554	19	)	)	-RRB-
en-wikipedia-org-3485	554	20	often	often	RB
en-wikipedia-org-3485	554	21	primes	prime	VBZ
en-wikipedia-org-3485	554	22	a	a	DT
en-wikipedia-org-3485	554	23	pulse	pulse	NN
en-wikipedia-org-3485	554	24	of	of	IN
en-wikipedia-org-3485	554	25	elevated	elevated	JJ
en-wikipedia-org-3485	554	26	motivation	motivation	NN
en-wikipedia-org-3485	554	27	to	to	TO
en-wikipedia-org-3485	554	28	obtain	obtain	VB
en-wikipedia-org-3485	554	29	and	and	CC
en-wikipedia-org-3485	554	30	consume	consume	VB
en-wikipedia-org-3485	554	31	more	more	JJR
en-wikipedia-org-3485	554	32	reward	reward	NN
en-wikipedia-org-3485	554	33	UCS	UCS	NNP
en-wikipedia-org-3485	554	34	.	.	.
en-wikipedia-org-3485	555	1	This	this	DT
en-wikipedia-org-3485	555	2	is	be	VBZ
en-wikipedia-org-3485	555	3	a	a	DT
en-wikipedia-org-3485	555	4	signature	signature	NN
en-wikipedia-org-3485	555	5	feature	feature	NN
en-wikipedia-org-3485	555	6	of	of	IN
en-wikipedia-org-3485	555	7	incentive	incentive	NN
en-wikipedia-org-3485	555	8	salience	salience	NN
en-wikipedia-org-3485	555	9	.	.	.
en-wikipedia-org-3485	556	1	Cue	Cue	NNP
en-wikipedia-org-3485	556	2	as	as	IN
en-wikipedia-org-3485	556	3	attractive	attractive	JJ
en-wikipedia-org-3485	556	4	motivational	motivational	JJ
en-wikipedia-org-3485	556	5	magnets	magnet	NNS
en-wikipedia-org-3485	556	6	When	when	WRB
en-wikipedia-org-3485	556	7	a	a	DT
en-wikipedia-org-3485	556	8	Pavlovian	Pavlovian	NNP
en-wikipedia-org-3485	556	9	CS+	CS+	NNP
en-wikipedia-org-3485	556	10	is	be	VBZ
en-wikipedia-org-3485	556	11	attributed	attribute	VBN
en-wikipedia-org-3485	556	12	with	with	IN
en-wikipedia-org-3485	556	13	incentive	incentive	NN
en-wikipedia-org-3485	556	14	salience	salience	NN
en-wikipedia-org-3485	556	15	it	-PRON-	PRP
en-wikipedia-org-3485	556	16	not	not	RB
en-wikipedia-org-3485	556	17	only	only	RB
en-wikipedia-org-3485	556	18	triggers	trigger	NNS
en-wikipedia-org-3485	556	19	'	'	POS
en-wikipedia-org-3485	556	20	wanting	want	VBG
en-wikipedia-org-3485	556	21	’	'	''
en-wikipedia-org-3485	556	22	for	for	IN
en-wikipedia-org-3485	556	23	its	-PRON-	PRP$
en-wikipedia-org-3485	556	24	UCS	UCS	NNP
en-wikipedia-org-3485	556	25	,	,	,
en-wikipedia-org-3485	556	26	but	but	CC
en-wikipedia-org-3485	556	27	often	often	RB
en-wikipedia-org-3485	556	28	the	the	DT
en-wikipedia-org-3485	556	29	cue	cue	NN
en-wikipedia-org-3485	556	30	itself	-PRON-	PRP
en-wikipedia-org-3485	556	31	becomes	become	VBZ
en-wikipedia-org-3485	556	32	highly	highly	RB
en-wikipedia-org-3485	556	33	attractive	attractive	JJ
en-wikipedia-org-3485	556	34	–	–	:
en-wikipedia-org-3485	556	35	even	even	RB
en-wikipedia-org-3485	556	36	to	to	IN
en-wikipedia-org-3485	556	37	an	an	DT
en-wikipedia-org-3485	556	38	irrational	irrational	JJ
en-wikipedia-org-3485	556	39	degree	degree	NN
en-wikipedia-org-3485	556	40	.	.	.
en-wikipedia-org-3485	557	1	This	this	DT
en-wikipedia-org-3485	557	2	cue	cue	NN
en-wikipedia-org-3485	557	3	attraction	attraction	NN
en-wikipedia-org-3485	557	4	is	be	VBZ
en-wikipedia-org-3485	557	5	another	another	DT
en-wikipedia-org-3485	557	6	signature	signature	NN
en-wikipedia-org-3485	557	7	feature	feature	NN
en-wikipedia-org-3485	557	8	of	of	IN
en-wikipedia-org-3485	557	9	incentive	incentive	NN
en-wikipedia-org-3485	557	10	salience	salience	NN
en-wikipedia-org-3485	557	11	 	  	_SP
en-wikipedia-org-3485	557	12	...	...	:
en-wikipedia-org-3485	557	13	Two	two	CD
en-wikipedia-org-3485	557	14	recognizable	recognizable	JJ
en-wikipedia-org-3485	557	15	features	feature	NNS
en-wikipedia-org-3485	557	16	of	of	IN
en-wikipedia-org-3485	557	17	incentive	incentive	NN
en-wikipedia-org-3485	557	18	salience	salience	NN
en-wikipedia-org-3485	557	19	are	be	VBP
en-wikipedia-org-3485	557	20	often	often	RB
en-wikipedia-org-3485	557	21	visible	visible	JJ
en-wikipedia-org-3485	557	22	that	that	WDT
en-wikipedia-org-3485	557	23	can	can	MD
en-wikipedia-org-3485	557	24	be	be	VB
en-wikipedia-org-3485	557	25	used	use	VBN
en-wikipedia-org-3485	557	26	in	in	IN
en-wikipedia-org-3485	557	27	neuroscience	neuroscience	NN
en-wikipedia-org-3485	557	28	experiments	experiment	NNS
en-wikipedia-org-3485	557	29	:	:	:
en-wikipedia-org-3485	557	30	(	(	-LRB-
en-wikipedia-org-3485	557	31	i	i	NN
en-wikipedia-org-3485	557	32	)	)	-RRB-
en-wikipedia-org-3485	557	33	UCS	UCS	NNP
en-wikipedia-org-3485	557	34	-	-	HYPH
en-wikipedia-org-3485	557	35	directed	direct	VBN
en-wikipedia-org-3485	557	36	'	'	``
en-wikipedia-org-3485	557	37	wanting	wanting	NN
en-wikipedia-org-3485	557	38	’	'	''
en-wikipedia-org-3485	557	39	–	–	:
en-wikipedia-org-3485	557	40	CS	CS	NNP
en-wikipedia-org-3485	557	41	-	-	HYPH
en-wikipedia-org-3485	557	42	triggered	trigger	VBN
en-wikipedia-org-3485	557	43	pulses	pulse	NNS
en-wikipedia-org-3485	557	44	of	of	IN
en-wikipedia-org-3485	557	45	intensified	intensify	VBN
en-wikipedia-org-3485	557	46	'	'	``
en-wikipedia-org-3485	557	47	wanting	want	VBG
en-wikipedia-org-3485	557	48	’	'	''
en-wikipedia-org-3485	557	49	for	for	IN
en-wikipedia-org-3485	557	50	the	the	DT
en-wikipedia-org-3485	557	51	UCS	UCS	NNP
en-wikipedia-org-3485	557	52	reward	reward	NN
en-wikipedia-org-3485	557	53	;	;	,
en-wikipedia-org-3485	557	54	and	and	CC
en-wikipedia-org-3485	557	55	(	(	-LRB-
en-wikipedia-org-3485	557	56	ii	ii	NNP
en-wikipedia-org-3485	557	57	)	)	-RRB-
en-wikipedia-org-3485	557	58	CS	CS	NNP
en-wikipedia-org-3485	557	59	-	-	HYPH
en-wikipedia-org-3485	557	60	directed	direct	VBN
en-wikipedia-org-3485	557	61	'	'	''
en-wikipedia-org-3485	557	62	wanting	wanting	NN
en-wikipedia-org-3485	557	63	’	'	''
en-wikipedia-org-3485	557	64	–	–	:
en-wikipedia-org-3485	557	65	motivated	motivated	JJ
en-wikipedia-org-3485	557	66	attraction	attraction	NN
en-wikipedia-org-3485	557	67	to	to	IN
en-wikipedia-org-3485	557	68	the	the	DT
en-wikipedia-org-3485	557	69	Pavlovian	pavlovian	JJ
en-wikipedia-org-3485	557	70	cue	cue	NN
en-wikipedia-org-3485	557	71	,	,	,
en-wikipedia-org-3485	557	72	which	which	WDT
en-wikipedia-org-3485	557	73	makes	make	VBZ
en-wikipedia-org-3485	557	74	the	the	DT
en-wikipedia-org-3485	557	75	arbitrary	arbitrary	JJ
en-wikipedia-org-3485	557	76	CS	CS	NNP
en-wikipedia-org-3485	557	77	stimulus	stimulus	NN
en-wikipedia-org-3485	557	78	into	into	IN
en-wikipedia-org-3485	557	79	a	a	DT
en-wikipedia-org-3485	557	80	motivational	motivational	JJ
en-wikipedia-org-3485	557	81	magnet	magnet	NN
en-wikipedia-org-3485	557	82	.	.	.
en-wikipedia-org-3485	558	1	^	^	NNP
en-wikipedia-org-3485	558	2	Malenka	Malenka	NNP
en-wikipedia-org-3485	558	3	RC	RC	NNP
en-wikipedia-org-3485	558	4	,	,	,
en-wikipedia-org-3485	558	5	Nestler	Nestler	NNP
en-wikipedia-org-3485	558	6	EJ	EJ	NNP
en-wikipedia-org-3485	558	7	,	,	,
en-wikipedia-org-3485	558	8	Hyman	Hyman	NNP
en-wikipedia-org-3485	558	9	SE	SE	NNP
en-wikipedia-org-3485	558	10	(	(	-LRB-
en-wikipedia-org-3485	558	11	2009	2009	CD
en-wikipedia-org-3485	558	12	)	)	-RRB-
en-wikipedia-org-3485	558	13	.	.	.
en-wikipedia-org-3485	559	1	Sydor	Sydor	NNP
en-wikipedia-org-3485	559	2	A	A	NNP
en-wikipedia-org-3485	559	3	,	,	,
en-wikipedia-org-3485	559	4	Brown	Brown	NNP
en-wikipedia-org-3485	559	5	RY	RY	NNP
en-wikipedia-org-3485	559	6	(	(	-LRB-
en-wikipedia-org-3485	559	7	eds	eds	NNP
en-wikipedia-org-3485	559	8	.	.	.
en-wikipedia-org-3485	559	9	)	)	-RRB-
en-wikipedia-org-3485	559	10	.	.	.
en-wikipedia-org-3485	560	1	Molecular	Molecular	NNP
en-wikipedia-org-3485	560	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-3485	560	3	:	:	:
en-wikipedia-org-3485	560	4	A	A	NNP
en-wikipedia-org-3485	560	5	Foundation	Foundation	NNP
en-wikipedia-org-3485	560	6	for	for	IN
en-wikipedia-org-3485	560	7	Clinical	Clinical	NNP
en-wikipedia-org-3485	560	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	560	9	(	(	-LRB-
en-wikipedia-org-3485	560	10	2nd	2nd	NNP
en-wikipedia-org-3485	560	11	ed	ed	NNP
en-wikipedia-org-3485	560	12	.	.	.
en-wikipedia-org-3485	560	13	)	)	-RRB-
en-wikipedia-org-3485	560	14	.	.	.
en-wikipedia-org-3485	561	1	New	New	NNP
en-wikipedia-org-3485	561	2	York	York	NNP
en-wikipedia-org-3485	561	3	:	:	:
en-wikipedia-org-3485	561	4	McGraw	McGraw	NNP
en-wikipedia-org-3485	561	5	-	-	HYPH
en-wikipedia-org-3485	561	6	Hill	Hill	NNP
en-wikipedia-org-3485	561	7	Medical	Medical	NNP
en-wikipedia-org-3485	561	8	.	.	.
en-wikipedia-org-3485	562	1	pp	pp	NNP
en-wikipedia-org-3485	562	2	.	.	.
en-wikipedia-org-3485	563	1	147–148	147–148	CD
en-wikipedia-org-3485	563	2	,	,	,
en-wikipedia-org-3485	563	3	367	367	CD
en-wikipedia-org-3485	563	4	,	,	,
en-wikipedia-org-3485	563	5	376	376	CD
en-wikipedia-org-3485	563	6	.	.	.
en-wikipedia-org-3485	564	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	564	2	 	  	_SP
en-wikipedia-org-3485	564	3	978	978	CD
en-wikipedia-org-3485	564	4	-	-	HYPH
en-wikipedia-org-3485	564	5	0	0	CD
en-wikipedia-org-3485	564	6	-	-	HYPH
en-wikipedia-org-3485	564	7	07	07	CD
en-wikipedia-org-3485	564	8	-	-	HYPH
en-wikipedia-org-3485	564	9	148127	148127	CD
en-wikipedia-org-3485	564	10	-	-	SYM
en-wikipedia-org-3485	564	11	4	4	CD
en-wikipedia-org-3485	564	12	.	.	.
en-wikipedia-org-3485	565	1	VTA	VTA	NNP
en-wikipedia-org-3485	565	2	DA	DA	NNP
en-wikipedia-org-3485	565	3	neurons	neuron	NNS
en-wikipedia-org-3485	565	4	play	play	VBP
en-wikipedia-org-3485	565	5	a	a	DT
en-wikipedia-org-3485	565	6	critical	critical	JJ
en-wikipedia-org-3485	565	7	role	role	NN
en-wikipedia-org-3485	565	8	in	in	IN
en-wikipedia-org-3485	565	9	motivation	motivation	NN
en-wikipedia-org-3485	565	10	,	,	,
en-wikipedia-org-3485	565	11	reward	reward	VB
en-wikipedia-org-3485	565	12	-	-	HYPH
en-wikipedia-org-3485	565	13	related	relate	VBN
en-wikipedia-org-3485	565	14	behavior	behavior	NN
en-wikipedia-org-3485	565	15	(	(	-LRB-
en-wikipedia-org-3485	565	16	Chapter	chapter	NN
en-wikipedia-org-3485	565	17	15	15	CD
en-wikipedia-org-3485	565	18	)	)	-RRB-
en-wikipedia-org-3485	565	19	,	,	,
en-wikipedia-org-3485	565	20	attention	attention	NN
en-wikipedia-org-3485	565	21	,	,	,
en-wikipedia-org-3485	565	22	and	and	CC
en-wikipedia-org-3485	565	23	multiple	multiple	JJ
en-wikipedia-org-3485	565	24	forms	form	NNS
en-wikipedia-org-3485	565	25	of	of	IN
en-wikipedia-org-3485	565	26	memory	memory	NN
en-wikipedia-org-3485	565	27	.	.	.
en-wikipedia-org-3485	566	1	This	this	DT
en-wikipedia-org-3485	566	2	organization	organization	NN
en-wikipedia-org-3485	566	3	of	of	IN
en-wikipedia-org-3485	566	4	the	the	DT
en-wikipedia-org-3485	566	5	DA	DA	NNP
en-wikipedia-org-3485	566	6	system	system	NN
en-wikipedia-org-3485	566	7	,	,	,
en-wikipedia-org-3485	566	8	wide	wide	JJ
en-wikipedia-org-3485	566	9	projection	projection	NN
en-wikipedia-org-3485	566	10	from	from	IN
en-wikipedia-org-3485	566	11	a	a	DT
en-wikipedia-org-3485	566	12	limited	limited	JJ
en-wikipedia-org-3485	566	13	number	number	NN
en-wikipedia-org-3485	566	14	of	of	IN
en-wikipedia-org-3485	566	15	cell	cell	NN
en-wikipedia-org-3485	566	16	bodies	body	NNS
en-wikipedia-org-3485	566	17	,	,	,
en-wikipedia-org-3485	566	18	permits	permit	VBZ
en-wikipedia-org-3485	566	19	coordinated	coordinate	VBD
en-wikipedia-org-3485	566	20	responses	response	NNS
en-wikipedia-org-3485	566	21	to	to	IN
en-wikipedia-org-3485	566	22	potent	potent	JJ
en-wikipedia-org-3485	566	23	new	new	JJ
en-wikipedia-org-3485	566	24	rewards	reward	NNS
en-wikipedia-org-3485	566	25	.	.	.
en-wikipedia-org-3485	567	1	Thus	thus	RB
en-wikipedia-org-3485	567	2	,	,	,
en-wikipedia-org-3485	567	3	acting	act	VBG
en-wikipedia-org-3485	567	4	in	in	IN
en-wikipedia-org-3485	567	5	diverse	diverse	JJ
en-wikipedia-org-3485	567	6	terminal	terminal	JJ
en-wikipedia-org-3485	567	7	fields	field	NNS
en-wikipedia-org-3485	567	8	,	,	,
en-wikipedia-org-3485	567	9	dopamine	dopamine	NN
en-wikipedia-org-3485	567	10	confers	confer	NNS
en-wikipedia-org-3485	567	11	motivational	motivational	JJ
en-wikipedia-org-3485	567	12	salience	salience	NN
en-wikipedia-org-3485	567	13	(	(	-LRB-
en-wikipedia-org-3485	567	14	"	"	``
en-wikipedia-org-3485	567	15	wanting	want	VBG
en-wikipedia-org-3485	567	16	"	"	''
en-wikipedia-org-3485	567	17	)	)	-RRB-
en-wikipedia-org-3485	567	18	on	on	IN
en-wikipedia-org-3485	567	19	the	the	DT
en-wikipedia-org-3485	567	20	reward	reward	NN
en-wikipedia-org-3485	567	21	itself	-PRON-	PRP
en-wikipedia-org-3485	567	22	or	or	CC
en-wikipedia-org-3485	567	23	associated	associate	VBN
en-wikipedia-org-3485	567	24	cues	cue	NNS
en-wikipedia-org-3485	567	25	(	(	-LRB-
en-wikipedia-org-3485	567	26	nucleus	nucleus	NNP
en-wikipedia-org-3485	567	27	accumbens	accumbens	NNP
en-wikipedia-org-3485	567	28	shell	shell	NNP
en-wikipedia-org-3485	567	29	region	region	NN
en-wikipedia-org-3485	567	30	)	)	-RRB-
en-wikipedia-org-3485	567	31	,	,	,
en-wikipedia-org-3485	567	32	updates	update	VBZ
en-wikipedia-org-3485	567	33	the	the	DT
en-wikipedia-org-3485	567	34	value	value	NN
en-wikipedia-org-3485	567	35	placed	place	VBN
en-wikipedia-org-3485	567	36	on	on	IN
en-wikipedia-org-3485	567	37	different	different	JJ
en-wikipedia-org-3485	567	38	goals	goal	NNS
en-wikipedia-org-3485	567	39	in	in	IN
en-wikipedia-org-3485	567	40	light	light	NN
en-wikipedia-org-3485	567	41	of	of	IN
en-wikipedia-org-3485	567	42	this	this	DT
en-wikipedia-org-3485	567	43	new	new	JJ
en-wikipedia-org-3485	567	44	experience	experience	NN
en-wikipedia-org-3485	567	45	(	(	-LRB-
en-wikipedia-org-3485	567	46	orbital	orbital	JJ
en-wikipedia-org-3485	567	47	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	567	48	cortex	cortex	NNP
en-wikipedia-org-3485	567	49	)	)	-RRB-
en-wikipedia-org-3485	567	50	,	,	,
en-wikipedia-org-3485	567	51	helps	help	VBZ
en-wikipedia-org-3485	567	52	consolidate	consolidate	VB
en-wikipedia-org-3485	567	53	multiple	multiple	JJ
en-wikipedia-org-3485	567	54	forms	form	NNS
en-wikipedia-org-3485	567	55	of	of	IN
en-wikipedia-org-3485	567	56	memory	memory	NN
en-wikipedia-org-3485	567	57	(	(	-LRB-
en-wikipedia-org-3485	567	58	amygdala	amygdala	NNP
en-wikipedia-org-3485	567	59	and	and	CC
en-wikipedia-org-3485	567	60	hippocampus	hippocampus	NNP
en-wikipedia-org-3485	567	61	)	)	-RRB-
en-wikipedia-org-3485	567	62	,	,	,
en-wikipedia-org-3485	567	63	and	and	CC
en-wikipedia-org-3485	567	64	encodes	encode	VBZ
en-wikipedia-org-3485	567	65	new	new	JJ
en-wikipedia-org-3485	567	66	motor	motor	NN
en-wikipedia-org-3485	567	67	programs	program	NNS
en-wikipedia-org-3485	567	68	that	that	WDT
en-wikipedia-org-3485	567	69	will	will	MD
en-wikipedia-org-3485	567	70	facilitate	facilitate	VB
en-wikipedia-org-3485	567	71	obtaining	obtain	VBG
en-wikipedia-org-3485	567	72	this	this	DT
en-wikipedia-org-3485	567	73	reward	reward	NN
en-wikipedia-org-3485	567	74	in	in	IN
en-wikipedia-org-3485	567	75	the	the	DT
en-wikipedia-org-3485	567	76	future	future	NN
en-wikipedia-org-3485	567	77	(	(	-LRB-
en-wikipedia-org-3485	567	78	nucleus	nucleus	NNP
en-wikipedia-org-3485	567	79	accumbens	accumben	VBZ
en-wikipedia-org-3485	567	80	core	core	NN
en-wikipedia-org-3485	567	81	region	region	NN
en-wikipedia-org-3485	567	82	and	and	CC
en-wikipedia-org-3485	567	83	dorsal	dorsal	NN
en-wikipedia-org-3485	567	84	striatum	striatum	NN
en-wikipedia-org-3485	567	85	)	)	-RRB-
en-wikipedia-org-3485	567	86	.	.	.
en-wikipedia-org-3485	568	1	In	in	IN
en-wikipedia-org-3485	568	2	this	this	DT
en-wikipedia-org-3485	568	3	example	example	NN
en-wikipedia-org-3485	568	4	,	,	,
en-wikipedia-org-3485	568	5	dopamine	dopamine	NN
en-wikipedia-org-3485	568	6	modulates	modulate	VBZ
en-wikipedia-org-3485	568	7	the	the	DT
en-wikipedia-org-3485	568	8	processing	processing	NN
en-wikipedia-org-3485	568	9	of	of	IN
en-wikipedia-org-3485	568	10	sensorimotor	sensorimotor	NN
en-wikipedia-org-3485	568	11	information	information	NN
en-wikipedia-org-3485	568	12	in	in	IN
en-wikipedia-org-3485	568	13	diverse	diverse	JJ
en-wikipedia-org-3485	568	14	neural	neural	JJ
en-wikipedia-org-3485	568	15	circuits	circuit	NNS
en-wikipedia-org-3485	568	16	to	to	TO
en-wikipedia-org-3485	568	17	maximize	maximize	VB
en-wikipedia-org-3485	568	18	the	the	DT
en-wikipedia-org-3485	568	19	ability	ability	NN
en-wikipedia-org-3485	568	20	of	of	IN
en-wikipedia-org-3485	568	21	the	the	DT
en-wikipedia-org-3485	568	22	organism	organism	NN
en-wikipedia-org-3485	568	23	to	to	TO
en-wikipedia-org-3485	568	24	obtain	obtain	VB
en-wikipedia-org-3485	568	25	future	future	JJ
en-wikipedia-org-3485	568	26	rewards	reward	NNS
en-wikipedia-org-3485	568	27	.	.	.
en-wikipedia-org-3485	569	1	...	...	NFP
en-wikipedia-org-3485	570	1	The	the	DT
en-wikipedia-org-3485	570	2	brain	brain	NN
en-wikipedia-org-3485	570	3	reward	reward	NN
en-wikipedia-org-3485	570	4	circuitry	circuitry	NN
en-wikipedia-org-3485	570	5	that	that	WDT
en-wikipedia-org-3485	570	6	is	be	VBZ
en-wikipedia-org-3485	570	7	targeted	target	VBN
en-wikipedia-org-3485	570	8	by	by	IN
en-wikipedia-org-3485	570	9	addictive	addictive	JJ
en-wikipedia-org-3485	570	10	drugs	drug	NNS
en-wikipedia-org-3485	570	11	normally	normally	RB
en-wikipedia-org-3485	570	12	mediates	mediate	VBZ
en-wikipedia-org-3485	570	13	the	the	DT
en-wikipedia-org-3485	570	14	pleasure	pleasure	NN
en-wikipedia-org-3485	570	15	and	and	CC
en-wikipedia-org-3485	570	16	strengthening	strengthening	NN
en-wikipedia-org-3485	570	17	of	of	IN
en-wikipedia-org-3485	570	18	behaviors	behavior	NNS
en-wikipedia-org-3485	570	19	associated	associate	VBN
en-wikipedia-org-3485	570	20	with	with	IN
en-wikipedia-org-3485	570	21	natural	natural	JJ
en-wikipedia-org-3485	570	22	reinforcers	reinforcer	NNS
en-wikipedia-org-3485	570	23	,	,	,
en-wikipedia-org-3485	570	24	such	such	JJ
en-wikipedia-org-3485	570	25	as	as	IN
en-wikipedia-org-3485	570	26	food	food	NN
en-wikipedia-org-3485	570	27	,	,	,
en-wikipedia-org-3485	570	28	water	water	NN
en-wikipedia-org-3485	570	29	,	,	,
en-wikipedia-org-3485	570	30	and	and	CC
en-wikipedia-org-3485	570	31	sexual	sexual	JJ
en-wikipedia-org-3485	570	32	contact	contact	NN
en-wikipedia-org-3485	570	33	.	.	.
en-wikipedia-org-3485	571	1	Dopamine	dopamine	NN
en-wikipedia-org-3485	571	2	neurons	neuron	NNS
en-wikipedia-org-3485	571	3	in	in	IN
en-wikipedia-org-3485	571	4	the	the	DT
en-wikipedia-org-3485	571	5	VTA	VTA	NNP
en-wikipedia-org-3485	571	6	are	be	VBP
en-wikipedia-org-3485	571	7	activated	activate	VBN
en-wikipedia-org-3485	571	8	by	by	IN
en-wikipedia-org-3485	571	9	food	food	NN
en-wikipedia-org-3485	571	10	and	and	CC
en-wikipedia-org-3485	571	11	water	water	NN
en-wikipedia-org-3485	571	12	,	,	,
en-wikipedia-org-3485	571	13	and	and	CC
en-wikipedia-org-3485	571	14	dopamine	dopamine	NN
en-wikipedia-org-3485	571	15	release	release	NN
en-wikipedia-org-3485	571	16	in	in	IN
en-wikipedia-org-3485	571	17	the	the	DT
en-wikipedia-org-3485	571	18	NAc	NAc	NNS
en-wikipedia-org-3485	571	19	is	be	VBZ
en-wikipedia-org-3485	571	20	stimulated	stimulate	VBN
en-wikipedia-org-3485	571	21	by	by	IN
en-wikipedia-org-3485	571	22	the	the	DT
en-wikipedia-org-3485	571	23	presence	presence	NN
en-wikipedia-org-3485	571	24	of	of	IN
en-wikipedia-org-3485	571	25	natural	natural	JJ
en-wikipedia-org-3485	571	26	reinforcers	reinforcer	NNS
en-wikipedia-org-3485	571	27	,	,	,
en-wikipedia-org-3485	571	28	such	such	JJ
en-wikipedia-org-3485	571	29	as	as	IN
en-wikipedia-org-3485	571	30	food	food	NN
en-wikipedia-org-3485	571	31	,	,	,
en-wikipedia-org-3485	571	32	water	water	NN
en-wikipedia-org-3485	571	33	,	,	,
en-wikipedia-org-3485	571	34	or	or	CC
en-wikipedia-org-3485	571	35	a	a	DT
en-wikipedia-org-3485	571	36	sexual	sexual	JJ
en-wikipedia-org-3485	571	37	partner	partner	NN
en-wikipedia-org-3485	571	38	.	.	.
en-wikipedia-org-3485	572	1	...	...	NFP
en-wikipedia-org-3485	573	1	The	the	DT
en-wikipedia-org-3485	573	2	NAc	NAc	NNS
en-wikipedia-org-3485	573	3	and	and	CC
en-wikipedia-org-3485	573	4	VTA	VTA	NNP
en-wikipedia-org-3485	573	5	are	be	VBP
en-wikipedia-org-3485	573	6	central	central	JJ
en-wikipedia-org-3485	573	7	components	component	NNS
en-wikipedia-org-3485	573	8	of	of	IN
en-wikipedia-org-3485	573	9	the	the	DT
en-wikipedia-org-3485	573	10	circuitry	circuitry	NN
en-wikipedia-org-3485	573	11	underlying	underlie	VBG
en-wikipedia-org-3485	573	12	reward	reward	NN
en-wikipedia-org-3485	573	13	and	and	CC
en-wikipedia-org-3485	573	14	memory	memory	NN
en-wikipedia-org-3485	573	15	of	of	IN
en-wikipedia-org-3485	573	16	reward	reward	NN
en-wikipedia-org-3485	573	17	.	.	.
en-wikipedia-org-3485	574	1	As	as	IN
en-wikipedia-org-3485	574	2	previously	previously	RB
en-wikipedia-org-3485	574	3	mentioned	mention	VBN
en-wikipedia-org-3485	574	4	,	,	,
en-wikipedia-org-3485	574	5	the	the	DT
en-wikipedia-org-3485	574	6	activity	activity	NN
en-wikipedia-org-3485	574	7	of	of	IN
en-wikipedia-org-3485	574	8	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	574	9	neurons	neuron	NNS
en-wikipedia-org-3485	574	10	in	in	IN
en-wikipedia-org-3485	574	11	the	the	DT
en-wikipedia-org-3485	574	12	VTA	VTA	NNP
en-wikipedia-org-3485	574	13	appears	appear	VBZ
en-wikipedia-org-3485	574	14	to	to	TO
en-wikipedia-org-3485	574	15	be	be	VB
en-wikipedia-org-3485	574	16	linked	link	VBN
en-wikipedia-org-3485	574	17	to	to	TO
en-wikipedia-org-3485	574	18	reward	reward	VB
en-wikipedia-org-3485	574	19	prediction	prediction	NN
en-wikipedia-org-3485	574	20	.	.	.
en-wikipedia-org-3485	575	1	The	the	DT
en-wikipedia-org-3485	575	2	NAc	NAc	NNS
en-wikipedia-org-3485	575	3	is	be	VBZ
en-wikipedia-org-3485	575	4	involved	involve	VBN
en-wikipedia-org-3485	575	5	in	in	IN
en-wikipedia-org-3485	575	6	learning	learn	VBG
en-wikipedia-org-3485	575	7	associated	associate	VBN
en-wikipedia-org-3485	575	8	with	with	IN
en-wikipedia-org-3485	575	9	reinforcement	reinforcement	NN
en-wikipedia-org-3485	575	10	and	and	CC
en-wikipedia-org-3485	575	11	the	the	DT
en-wikipedia-org-3485	575	12	modulation	modulation	NN
en-wikipedia-org-3485	575	13	of	of	IN
en-wikipedia-org-3485	575	14	motoric	motoric	JJ
en-wikipedia-org-3485	575	15	responses	response	NNS
en-wikipedia-org-3485	575	16	to	to	IN
en-wikipedia-org-3485	575	17	stimuli	stimulus	NNS
en-wikipedia-org-3485	575	18	that	that	WDT
en-wikipedia-org-3485	575	19	satisfy	satisfy	VBP
en-wikipedia-org-3485	575	20	internal	internal	JJ
en-wikipedia-org-3485	575	21	homeostatic	homeostatic	JJ
en-wikipedia-org-3485	575	22	needs	need	NNS
en-wikipedia-org-3485	575	23	.	.	.
en-wikipedia-org-3485	576	1	The	the	DT
en-wikipedia-org-3485	576	2	shell	shell	NN
en-wikipedia-org-3485	576	3	of	of	IN
en-wikipedia-org-3485	576	4	the	the	DT
en-wikipedia-org-3485	576	5	NAc	NAc	NNS
en-wikipedia-org-3485	576	6	appears	appear	VBZ
en-wikipedia-org-3485	576	7	to	to	TO
en-wikipedia-org-3485	576	8	be	be	VB
en-wikipedia-org-3485	576	9	particularly	particularly	RB
en-wikipedia-org-3485	576	10	important	important	JJ
en-wikipedia-org-3485	576	11	to	to	IN
en-wikipedia-org-3485	576	12	initial	initial	JJ
en-wikipedia-org-3485	576	13	drug	drug	NN
en-wikipedia-org-3485	576	14	actions	action	NNS
en-wikipedia-org-3485	576	15	within	within	IN
en-wikipedia-org-3485	576	16	reward	reward	NN
en-wikipedia-org-3485	576	17	circuitry	circuitry	NN
en-wikipedia-org-3485	576	18	;	;	:
en-wikipedia-org-3485	576	19	addictive	addictive	JJ
en-wikipedia-org-3485	576	20	drugs	drug	NNS
en-wikipedia-org-3485	576	21	appear	appear	VBP
en-wikipedia-org-3485	576	22	to	to	TO
en-wikipedia-org-3485	576	23	have	have	VB
en-wikipedia-org-3485	576	24	a	a	DT
en-wikipedia-org-3485	576	25	greater	great	JJR
en-wikipedia-org-3485	576	26	effect	effect	NN
en-wikipedia-org-3485	576	27	on	on	IN
en-wikipedia-org-3485	576	28	dopamine	dopamine	NN
en-wikipedia-org-3485	576	29	release	release	NN
en-wikipedia-org-3485	576	30	in	in	IN
en-wikipedia-org-3485	576	31	the	the	DT
en-wikipedia-org-3485	576	32	shell	shell	NN
en-wikipedia-org-3485	576	33	than	than	IN
en-wikipedia-org-3485	576	34	in	in	IN
en-wikipedia-org-3485	576	35	the	the	DT
en-wikipedia-org-3485	576	36	core	core	NN
en-wikipedia-org-3485	576	37	of	of	IN
en-wikipedia-org-3485	576	38	the	the	DT
en-wikipedia-org-3485	576	39	NAc	NAc	NNS
en-wikipedia-org-3485	576	40	.	.	.
en-wikipedia-org-3485	577	1	^	^	NNP
en-wikipedia-org-3485	577	2	Berridge	Berridge	NNP
en-wikipedia-org-3485	577	3	KC	KC	NNP
en-wikipedia-org-3485	577	4	,	,	,
en-wikipedia-org-3485	577	5	Kringelbach	Kringelbach	NNP
en-wikipedia-org-3485	577	6	ML	ML	NNP
en-wikipedia-org-3485	577	7	(	(	-LRB-
en-wikipedia-org-3485	577	8	1	1	CD
en-wikipedia-org-3485	577	9	June	June	NNP
en-wikipedia-org-3485	577	10	2013	2013	CD
en-wikipedia-org-3485	577	11	)	)	-RRB-
en-wikipedia-org-3485	577	12	.	.	.
en-wikipedia-org-3485	578	1	"	"	``
en-wikipedia-org-3485	578	2	Neuroscience	neuroscience	NN
en-wikipedia-org-3485	578	3	of	of	IN
en-wikipedia-org-3485	578	4	affect	affect	NN
en-wikipedia-org-3485	578	5	:	:	:
en-wikipedia-org-3485	578	6	brain	brain	NN
en-wikipedia-org-3485	578	7	mechanisms	mechanism	NNS
en-wikipedia-org-3485	578	8	of	of	IN
en-wikipedia-org-3485	578	9	pleasure	pleasure	NN
en-wikipedia-org-3485	578	10	and	and	CC
en-wikipedia-org-3485	578	11	displeasure	displeasure	NN
en-wikipedia-org-3485	578	12	"	"	''
en-wikipedia-org-3485	578	13	.	.	.
en-wikipedia-org-3485	579	1	Current	current	JJ
en-wikipedia-org-3485	579	2	Opinion	Opinion	NNP
en-wikipedia-org-3485	579	3	in	in	IN
en-wikipedia-org-3485	579	4	Neurobiology	Neurobiology	NNP
en-wikipedia-org-3485	579	5	.	.	.
en-wikipedia-org-3485	580	1	23	23	CD
en-wikipedia-org-3485	580	2	(	(	-LRB-
en-wikipedia-org-3485	580	3	3	3	CD
en-wikipedia-org-3485	580	4	)	)	-RRB-
en-wikipedia-org-3485	580	5	:	:	:
en-wikipedia-org-3485	580	6	294–303	294–303	CD
en-wikipedia-org-3485	580	7	.	.	.
en-wikipedia-org-3485	581	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	581	2	/	/	SYM
en-wikipedia-org-3485	581	3	j.conb.2013.01.017	j.conb.2013.01.017	NN
en-wikipedia-org-3485	581	4	.	.	.
en-wikipedia-org-3485	582	1	PMC	PMC	NNP
en-wikipedia-org-3485	582	2	 	  	_SP
en-wikipedia-org-3485	582	3	3644539	3644539	CD
en-wikipedia-org-3485	582	4	.	.	.
en-wikipedia-org-3485	583	1	PMID	PMID	NNP
en-wikipedia-org-3485	583	2	 	  	_SP
en-wikipedia-org-3485	583	3	23375169	23375169	CD
en-wikipedia-org-3485	583	4	.	.	.
en-wikipedia-org-3485	584	1	For	for	IN
en-wikipedia-org-3485	584	2	instance	instance	NN
en-wikipedia-org-3485	584	3	,	,	,
en-wikipedia-org-3485	584	4	mesolimbic	mesolimbic	JJ
en-wikipedia-org-3485	584	5	dopamine	dopamine	NN
en-wikipedia-org-3485	584	6	,	,	,
en-wikipedia-org-3485	584	7	probably	probably	RB
en-wikipedia-org-3485	584	8	the	the	DT
en-wikipedia-org-3485	584	9	most	most	RBS
en-wikipedia-org-3485	584	10	popular	popular	JJ
en-wikipedia-org-3485	584	11	brain	brain	NN
en-wikipedia-org-3485	584	12	neurotransmitter	neurotransmitter	NN
en-wikipedia-org-3485	584	13	candidate	candidate	NN
en-wikipedia-org-3485	584	14	for	for	IN
en-wikipedia-org-3485	584	15	pleasure	pleasure	NN
en-wikipedia-org-3485	584	16	two	two	CD
en-wikipedia-org-3485	584	17	decades	decade	NNS
en-wikipedia-org-3485	584	18	ago	ago	RB
en-wikipedia-org-3485	584	19	,	,	,
en-wikipedia-org-3485	584	20	turns	turn	VBZ
en-wikipedia-org-3485	584	21	out	out	RP
en-wikipedia-org-3485	584	22	not	not	RB
en-wikipedia-org-3485	584	23	to	to	TO
en-wikipedia-org-3485	584	24	cause	cause	VB
en-wikipedia-org-3485	584	25	pleasure	pleasure	NN
en-wikipedia-org-3485	584	26	or	or	CC
en-wikipedia-org-3485	584	27	liking	like	VBG
en-wikipedia-org-3485	584	28	at	at	RB
en-wikipedia-org-3485	584	29	all	all	RB
en-wikipedia-org-3485	584	30	.	.	.
en-wikipedia-org-3485	585	1	Rather	rather	RB
en-wikipedia-org-3485	585	2	dopamine	dopamine	VB
en-wikipedia-org-3485	585	3	more	more	RBR
en-wikipedia-org-3485	585	4	selectively	selectively	RB
en-wikipedia-org-3485	585	5	mediates	mediate	VBZ
en-wikipedia-org-3485	585	6	a	a	DT
en-wikipedia-org-3485	585	7	motivational	motivational	JJ
en-wikipedia-org-3485	585	8	process	process	NN
en-wikipedia-org-3485	585	9	of	of	IN
en-wikipedia-org-3485	585	10	incentive	incentive	NN
en-wikipedia-org-3485	585	11	salience	salience	NN
en-wikipedia-org-3485	585	12	,	,	,
en-wikipedia-org-3485	585	13	which	which	WDT
en-wikipedia-org-3485	585	14	is	be	VBZ
en-wikipedia-org-3485	585	15	a	a	DT
en-wikipedia-org-3485	585	16	mechanism	mechanism	NN
en-wikipedia-org-3485	585	17	for	for	IN
en-wikipedia-org-3485	585	18	wanting	want	VBG
en-wikipedia-org-3485	585	19	rewards	reward	NNS
en-wikipedia-org-3485	585	20	but	but	CC
en-wikipedia-org-3485	585	21	not	not	RB
en-wikipedia-org-3485	585	22	for	for	IN
en-wikipedia-org-3485	585	23	liking	like	VBG
en-wikipedia-org-3485	585	24	them	-PRON-	PRP
en-wikipedia-org-3485	585	25	 	  	_SP
en-wikipedia-org-3485	585	26	....	....	.
en-wikipedia-org-3485	585	27	Rather	rather	RB
en-wikipedia-org-3485	585	28	opioid	opioid	JJ
en-wikipedia-org-3485	585	29	stimulation	stimulation	NN
en-wikipedia-org-3485	585	30	has	have	VBZ
en-wikipedia-org-3485	585	31	the	the	DT
en-wikipedia-org-3485	585	32	special	special	JJ
en-wikipedia-org-3485	585	33	capacity	capacity	NN
en-wikipedia-org-3485	585	34	to	to	TO
en-wikipedia-org-3485	585	35	enhance	enhance	VB
en-wikipedia-org-3485	585	36	liking	like	VBG
en-wikipedia-org-3485	585	37	only	only	RB
en-wikipedia-org-3485	585	38	if	if	IN
en-wikipedia-org-3485	585	39	the	the	DT
en-wikipedia-org-3485	585	40	stimulation	stimulation	NN
en-wikipedia-org-3485	585	41	occurs	occur	VBZ
en-wikipedia-org-3485	585	42	within	within	IN
en-wikipedia-org-3485	585	43	an	an	DT
en-wikipedia-org-3485	585	44	anatomical	anatomical	JJ
en-wikipedia-org-3485	585	45	hotspot	hotspot	NN
en-wikipedia-org-3485	585	46	^	^	.
en-wikipedia-org-3485	585	47	Calipari	Calipari	NNP
en-wikipedia-org-3485	585	48	,	,	,
en-wikipedia-org-3485	585	49	Erin	Erin	NNP
en-wikipedia-org-3485	585	50	S.	S.	NNP
en-wikipedia-org-3485	585	51	;	;	:
en-wikipedia-org-3485	585	52	Bagot	Bagot	NNP
en-wikipedia-org-3485	585	53	,	,	,
en-wikipedia-org-3485	585	54	Rosemary	Rosemary	NNP
en-wikipedia-org-3485	585	55	C.	C.	NNP
en-wikipedia-org-3485	585	56	;	;	:
en-wikipedia-org-3485	585	57	Purushothaman	Purushothaman	NNP
en-wikipedia-org-3485	585	58	,	,	,
en-wikipedia-org-3485	585	59	Immanuel	Immanuel	NNP
en-wikipedia-org-3485	585	60	;	;	:
en-wikipedia-org-3485	585	61	Davidson	Davidson	NNP
en-wikipedia-org-3485	585	62	,	,	,
en-wikipedia-org-3485	585	63	Thomas	Thomas	NNP
en-wikipedia-org-3485	585	64	J.	J.	NNP
en-wikipedia-org-3485	585	65	;	;	:
en-wikipedia-org-3485	585	66	Yorgason	Yorgason	NNP
en-wikipedia-org-3485	585	67	,	,	,
en-wikipedia-org-3485	585	68	Jordan	Jordan	NNP
en-wikipedia-org-3485	585	69	T.	T.	NNP
en-wikipedia-org-3485	585	70	;	;	:
en-wikipedia-org-3485	585	71	Peña	Peña	NNP
en-wikipedia-org-3485	585	72	,	,	,
en-wikipedia-org-3485	585	73	Catherine	Catherine	NNP
en-wikipedia-org-3485	585	74	J.	J.	NNP
en-wikipedia-org-3485	585	75	;	;	:
en-wikipedia-org-3485	585	76	Walker	Walker	NNP
en-wikipedia-org-3485	585	77	,	,	,
en-wikipedia-org-3485	585	78	Deena	Deena	NNP
en-wikipedia-org-3485	585	79	M.	M.	NNP
en-wikipedia-org-3485	585	80	;	;	:
en-wikipedia-org-3485	585	81	Pirpinias	Pirpinias	NNP
en-wikipedia-org-3485	585	82	,	,	,
en-wikipedia-org-3485	585	83	Stephen	Stephen	NNP
en-wikipedia-org-3485	585	84	T.	T.	NNP
en-wikipedia-org-3485	585	85	;	;	:
en-wikipedia-org-3485	585	86	Guise	Guise	NNP
en-wikipedia-org-3485	585	87	,	,	,
en-wikipedia-org-3485	585	88	Kevin	Kevin	NNP
en-wikipedia-org-3485	585	89	G.	G.	NNP
en-wikipedia-org-3485	585	90	;	;	:
en-wikipedia-org-3485	585	91	Ramakrishnan	Ramakrishnan	NNP
en-wikipedia-org-3485	585	92	,	,	,
en-wikipedia-org-3485	585	93	Charu	Charu	NNP
en-wikipedia-org-3485	585	94	;	;	:
en-wikipedia-org-3485	585	95	Deisseroth	Deisseroth	NNP
en-wikipedia-org-3485	585	96	,	,	,
en-wikipedia-org-3485	585	97	Karl	Karl	NNP
en-wikipedia-org-3485	585	98	;	;	:
en-wikipedia-org-3485	585	99	Nestler	Nestler	NNP
en-wikipedia-org-3485	585	100	,	,	,
en-wikipedia-org-3485	585	101	Eric	Eric	NNP
en-wikipedia-org-3485	585	102	J.	J.	NNP
en-wikipedia-org-3485	586	1	(	(	-LRB-
en-wikipedia-org-3485	586	2	8	8	CD
en-wikipedia-org-3485	586	3	March	March	NNP
en-wikipedia-org-3485	586	4	2016	2016	CD
en-wikipedia-org-3485	586	5	)	)	-RRB-
en-wikipedia-org-3485	586	6	.	.	.
en-wikipedia-org-3485	587	1	"	"	``
en-wikipedia-org-3485	587	2	In	in	IN
en-wikipedia-org-3485	587	3	vivo	vivo	NNP
en-wikipedia-org-3485	587	4	imaging	imaging	NN
en-wikipedia-org-3485	587	5	identifies	identify	VBZ
en-wikipedia-org-3485	587	6	temporal	temporal	JJ
en-wikipedia-org-3485	587	7	signature	signature	NN
en-wikipedia-org-3485	587	8	of	of	IN
en-wikipedia-org-3485	587	9	D1	d1	NN
en-wikipedia-org-3485	587	10	and	and	CC
en-wikipedia-org-3485	587	11	D2	D2	NNP
en-wikipedia-org-3485	587	12	medium	medium	JJ
en-wikipedia-org-3485	587	13	spiny	spiny	JJ
en-wikipedia-org-3485	587	14	neurons	neuron	NNS
en-wikipedia-org-3485	587	15	in	in	IN
en-wikipedia-org-3485	587	16	cocaine	cocaine	NN
en-wikipedia-org-3485	587	17	reward	reward	NN
en-wikipedia-org-3485	587	18	"	"	''
en-wikipedia-org-3485	587	19	.	.	.
en-wikipedia-org-3485	588	1	Proceedings	proceeding	NNS
en-wikipedia-org-3485	588	2	of	of	IN
en-wikipedia-org-3485	588	3	the	the	DT
en-wikipedia-org-3485	588	4	National	National	NNP
en-wikipedia-org-3485	588	5	Academy	Academy	NNP
en-wikipedia-org-3485	588	6	of	of	IN
en-wikipedia-org-3485	588	7	Sciences	Sciences	NNPS
en-wikipedia-org-3485	588	8	.	.	.
en-wikipedia-org-3485	589	1	113	113	CD
en-wikipedia-org-3485	589	2	(	(	-LRB-
en-wikipedia-org-3485	589	3	10	10	CD
en-wikipedia-org-3485	589	4	)	)	-RRB-
en-wikipedia-org-3485	589	5	:	:	:
en-wikipedia-org-3485	589	6	2726–2731	2726–2731	CD
en-wikipedia-org-3485	589	7	.	.	.
en-wikipedia-org-3485	590	1	Bibcode:2016PNAS	Bibcode:2016PNAS	NFP
en-wikipedia-org-3485	590	2	..	..	NFP
en-wikipedia-org-3485	590	3	113.2726C.	113.2726c.	CD
en-wikipedia-org-3485	591	1	doi:10.1073	doi:10.1073	NNP
en-wikipedia-org-3485	591	2	/	/	SYM
en-wikipedia-org-3485	591	3	pnas.1521238113	pnas.1521238113	NNP
en-wikipedia-org-3485	591	4	.	.	.
en-wikipedia-org-3485	592	1	PMC	PMC	NNP
en-wikipedia-org-3485	592	2	 	  	_SP
en-wikipedia-org-3485	592	3	4791010	4791010	CD
en-wikipedia-org-3485	592	4	.	.	.
en-wikipedia-org-3485	593	1	PMID	PMID	NNP
en-wikipedia-org-3485	593	2	 	  	_SP
en-wikipedia-org-3485	593	3	26831103	26831103	CD
en-wikipedia-org-3485	593	4	.	.	.
en-wikipedia-org-3485	594	1	^	^	NFP
en-wikipedia-org-3485	594	2	Baliki	Baliki	NNP
en-wikipedia-org-3485	594	3	,	,	,
en-wikipedia-org-3485	594	4	M.	M.	NNP
en-wikipedia-org-3485	594	5	N.	N.	NNP
en-wikipedia-org-3485	594	6	;	;	:
en-wikipedia-org-3485	594	7	Mansour	Mansour	NNP
en-wikipedia-org-3485	594	8	,	,	,
en-wikipedia-org-3485	594	9	A.	a.	NN
en-wikipedia-org-3485	594	10	;	;	:
en-wikipedia-org-3485	594	11	Baria	Baria	NNP
en-wikipedia-org-3485	594	12	,	,	,
en-wikipedia-org-3485	594	13	A.	A.	NNP
en-wikipedia-org-3485	594	14	T.	T.	NNP
en-wikipedia-org-3485	594	15	;	;	:
en-wikipedia-org-3485	594	16	Huang	Huang	NNP
en-wikipedia-org-3485	594	17	,	,	,
en-wikipedia-org-3485	594	18	L.	L.	NNP
en-wikipedia-org-3485	594	19	;	;	:
en-wikipedia-org-3485	594	20	Berger	Berger	NNP
en-wikipedia-org-3485	594	21	,	,	,
en-wikipedia-org-3485	594	22	S.	S.	NNP
en-wikipedia-org-3485	594	23	E.	E.	NNP
en-wikipedia-org-3485	594	24	;	;	:
en-wikipedia-org-3485	594	25	Fields	Fields	NNP
en-wikipedia-org-3485	594	26	,	,	,
en-wikipedia-org-3485	594	27	H.	H.	NNP
en-wikipedia-org-3485	594	28	L.	L.	NNP
en-wikipedia-org-3485	594	29	;	;	:
en-wikipedia-org-3485	594	30	Apkarian	Apkarian	NNP
en-wikipedia-org-3485	594	31	,	,	,
en-wikipedia-org-3485	594	32	A.	a.	NN
en-wikipedia-org-3485	594	33	V.	v.	NN
en-wikipedia-org-3485	594	34	(	(	-LRB-
en-wikipedia-org-3485	594	35	9	9	CD
en-wikipedia-org-3485	594	36	October	October	NNP
en-wikipedia-org-3485	594	37	2013	2013	CD
en-wikipedia-org-3485	594	38	)	)	-RRB-
en-wikipedia-org-3485	594	39	.	.	.
en-wikipedia-org-3485	595	1	"	"	``
en-wikipedia-org-3485	595	2	Parceling	parcel	VBG
en-wikipedia-org-3485	595	3	Human	human	JJ
en-wikipedia-org-3485	595	4	Accumbens	Accumbens	NNPS
en-wikipedia-org-3485	595	5	into	into	IN
en-wikipedia-org-3485	595	6	Putative	putative	JJ
en-wikipedia-org-3485	595	7	Core	Core	NNP
en-wikipedia-org-3485	595	8	and	and	CC
en-wikipedia-org-3485	595	9	Shell	Shell	NNP
en-wikipedia-org-3485	595	10	Dissociates	Dissociates	NNP
en-wikipedia-org-3485	595	11	Encoding	encode	VBG
en-wikipedia-org-3485	595	12	of	of	IN
en-wikipedia-org-3485	595	13	Values	value	NNS
en-wikipedia-org-3485	595	14	for	for	IN
en-wikipedia-org-3485	595	15	Reward	Reward	NNP
en-wikipedia-org-3485	595	16	and	and	CC
en-wikipedia-org-3485	595	17	Pain	Pain	NNP
en-wikipedia-org-3485	595	18	"	"	''
en-wikipedia-org-3485	595	19	.	.	.
en-wikipedia-org-3485	596	1	Journal	Journal	NNP
en-wikipedia-org-3485	596	2	of	of	IN
en-wikipedia-org-3485	596	3	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	596	4	.	.	.
en-wikipedia-org-3485	597	1	33	33	CD
en-wikipedia-org-3485	597	2	(	(	-LRB-
en-wikipedia-org-3485	597	3	41	41	CD
en-wikipedia-org-3485	597	4	)	)	-RRB-
en-wikipedia-org-3485	597	5	:	:	:
en-wikipedia-org-3485	597	6	16383–16393	16383–16393	CD
en-wikipedia-org-3485	597	7	.	.	.
en-wikipedia-org-3485	598	1	doi:10.1523	doi:10.1523	NNP
en-wikipedia-org-3485	598	2	/	/	SYM
en-wikipedia-org-3485	598	3	JNEUROSCI.1731	JNEUROSCI.1731	NNP
en-wikipedia-org-3485	598	4	-	-	HYPH
en-wikipedia-org-3485	598	5	13.2013	13.2013	NNP
en-wikipedia-org-3485	598	6	.	.	.
en-wikipedia-org-3485	599	1	PMC	PMC	NNP
en-wikipedia-org-3485	599	2	 	  	_SP
en-wikipedia-org-3485	599	3	3792469	3792469	CD
en-wikipedia-org-3485	599	4	.	.	.
en-wikipedia-org-3485	600	1	PMID	PMID	NNP
en-wikipedia-org-3485	600	2	 	  	_SP
en-wikipedia-org-3485	600	3	24107968	24107968	CD
en-wikipedia-org-3485	600	4	.	.	.
en-wikipedia-org-3485	601	1	^	^	NNP
en-wikipedia-org-3485	601	2	Soares	Soares	NNP
en-wikipedia-org-3485	601	3	-	-	HYPH
en-wikipedia-org-3485	601	4	Cunha	Cunha	NNP
en-wikipedia-org-3485	601	5	,	,	,
en-wikipedia-org-3485	601	6	Carina	Carina	NNP
en-wikipedia-org-3485	601	7	;	;	:
en-wikipedia-org-3485	601	8	Coimbra	Coimbra	NNP
en-wikipedia-org-3485	601	9	,	,	,
en-wikipedia-org-3485	601	10	Barbara	Barbara	NNP
en-wikipedia-org-3485	601	11	;	;	:
en-wikipedia-org-3485	601	12	Sousa	Sousa	NNP
en-wikipedia-org-3485	601	13	,	,	,
en-wikipedia-org-3485	601	14	Nuno	Nuno	NNP
en-wikipedia-org-3485	601	15	;	;	:
en-wikipedia-org-3485	601	16	Rodrigues	Rodrigues	NNP
en-wikipedia-org-3485	601	17	,	,	,
en-wikipedia-org-3485	601	18	Ana	Ana	NNP
en-wikipedia-org-3485	601	19	J.	J.	NNP
en-wikipedia-org-3485	602	1	(	(	-LRB-
en-wikipedia-org-3485	602	2	September	September	NNP
en-wikipedia-org-3485	602	3	2016	2016	CD
en-wikipedia-org-3485	602	4	)	)	-RRB-
en-wikipedia-org-3485	602	5	.	.	.
en-wikipedia-org-3485	603	1	"	"	``
en-wikipedia-org-3485	603	2	Reappraising	reappraise	VBG
en-wikipedia-org-3485	603	3	striatal	striatal	JJ
en-wikipedia-org-3485	603	4	D1-	d1-	NN
en-wikipedia-org-3485	603	5	and	and	CC
en-wikipedia-org-3485	603	6	D2-neurons	d2-neuron	NNS
en-wikipedia-org-3485	603	7	in	in	IN
en-wikipedia-org-3485	603	8	reward	reward	NN
en-wikipedia-org-3485	603	9	and	and	CC
en-wikipedia-org-3485	603	10	aversion	aversion	NN
en-wikipedia-org-3485	603	11	"	"	''
en-wikipedia-org-3485	603	12	.	.	.
en-wikipedia-org-3485	604	1	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	604	2	&	&	CC
en-wikipedia-org-3485	604	3	Biobehavioral	Biobehavioral	NNP
en-wikipedia-org-3485	604	4	Reviews	Reviews	NNPS
en-wikipedia-org-3485	604	5	.	.	.
en-wikipedia-org-3485	605	1	68	68	CD
en-wikipedia-org-3485	605	2	:	:	:
en-wikipedia-org-3485	605	3	370–386	370–386	CD
en-wikipedia-org-3485	605	4	.	.	.
en-wikipedia-org-3485	606	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	606	2	/	/	SYM
en-wikipedia-org-3485	606	3	j.neubiorev.2016.05.021	j.neubiorev.2016.05.021	NN
en-wikipedia-org-3485	606	4	.	.	.
en-wikipedia-org-3485	607	1	hdl:1822/47044	hdl:1822/47044	NNP
en-wikipedia-org-3485	607	2	.	.	.
en-wikipedia-org-3485	608	1	PMID	PMID	NNP
en-wikipedia-org-3485	608	2	 	  	_SP
en-wikipedia-org-3485	608	3	27235078	27235078	CD
en-wikipedia-org-3485	608	4	.	.	.
en-wikipedia-org-3485	609	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	609	2	 	  	_SP
en-wikipedia-org-3485	609	3	207092810	207092810	CD
en-wikipedia-org-3485	609	4	.	.	.
en-wikipedia-org-3485	610	1	^	^	NNP
en-wikipedia-org-3485	610	2	Bamford	Bamford	NNP
en-wikipedia-org-3485	610	3	,	,	,
en-wikipedia-org-3485	610	4	Nigel	Nigel	NNP
en-wikipedia-org-3485	610	5	S.	S.	NNP
en-wikipedia-org-3485	610	6	;	;	:
en-wikipedia-org-3485	610	7	Wightman	Wightman	NNP
en-wikipedia-org-3485	610	8	,	,	,
en-wikipedia-org-3485	610	9	R.	R.	NNP
en-wikipedia-org-3485	610	10	Mark	Mark	NNP
en-wikipedia-org-3485	610	11	;	;	:
en-wikipedia-org-3485	610	12	Sulzer	Sulzer	NNP
en-wikipedia-org-3485	610	13	,	,	,
en-wikipedia-org-3485	610	14	David	David	NNP
en-wikipedia-org-3485	610	15	(	(	-LRB-
en-wikipedia-org-3485	610	16	February	February	NNP
en-wikipedia-org-3485	610	17	2018	2018	CD
en-wikipedia-org-3485	610	18	)	)	-RRB-
en-wikipedia-org-3485	610	19	.	.	.
en-wikipedia-org-3485	611	1	"	"	``
en-wikipedia-org-3485	611	2	Dopamine	Dopamine	NNP
en-wikipedia-org-3485	611	3	's	's	POS
en-wikipedia-org-3485	611	4	Effects	Effects	NNPS
en-wikipedia-org-3485	611	5	on	on	IN
en-wikipedia-org-3485	611	6	Corticostriatal	Corticostriatal	NNP
en-wikipedia-org-3485	611	7	Synapses	Synapses	NNPS
en-wikipedia-org-3485	611	8	during	during	IN
en-wikipedia-org-3485	611	9	Reward	Reward	NNP
en-wikipedia-org-3485	611	10	-	-	HYPH
en-wikipedia-org-3485	611	11	Based	Based	NNP
en-wikipedia-org-3485	611	12	Behaviors	Behaviors	NNPS
en-wikipedia-org-3485	611	13	"	"	''
en-wikipedia-org-3485	611	14	.	.	.
en-wikipedia-org-3485	612	1	Neuron	neuron	UH
en-wikipedia-org-3485	612	2	.	.	.
en-wikipedia-org-3485	613	1	97	97	CD
en-wikipedia-org-3485	613	2	(	(	-LRB-
en-wikipedia-org-3485	613	3	3	3	CD
en-wikipedia-org-3485	613	4	)	)	-RRB-
en-wikipedia-org-3485	613	5	:	:	:
en-wikipedia-org-3485	613	6	494–510	494–510	CD
en-wikipedia-org-3485	613	7	.	.	.
en-wikipedia-org-3485	614	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	614	2	/	/	SYM
en-wikipedia-org-3485	614	3	j.neuron.2018.01.006	j.neuron.2018.01.006	NN
en-wikipedia-org-3485	614	4	.	.	.
en-wikipedia-org-3485	615	1	PMC	PMC	NNP
en-wikipedia-org-3485	615	2	 	  	_SP
en-wikipedia-org-3485	615	3	5808590	5808590	CD
en-wikipedia-org-3485	615	4	.	.	.
en-wikipedia-org-3485	616	1	PMID	PMID	NNP
en-wikipedia-org-3485	616	2	 	  	_SP
en-wikipedia-org-3485	616	3	29420932	29420932	CD
en-wikipedia-org-3485	616	4	.	.	.
en-wikipedia-org-3485	617	1	^	^	NNP
en-wikipedia-org-3485	617	2	Soares	Soares	NNP
en-wikipedia-org-3485	617	3	-	-	HYPH
en-wikipedia-org-3485	617	4	Cunha	Cunha	NNP
en-wikipedia-org-3485	617	5	,	,	,
en-wikipedia-org-3485	617	6	Carina	Carina	NNP
en-wikipedia-org-3485	617	7	;	;	:
en-wikipedia-org-3485	617	8	Coimbra	Coimbra	NNP
en-wikipedia-org-3485	617	9	,	,	,
en-wikipedia-org-3485	617	10	Barbara	Barbara	NNP
en-wikipedia-org-3485	617	11	;	;	:
en-wikipedia-org-3485	617	12	David	David	NNP
en-wikipedia-org-3485	617	13	-	-	HYPH
en-wikipedia-org-3485	617	14	Pereira	Pereira	NNP
en-wikipedia-org-3485	617	15	,	,	,
en-wikipedia-org-3485	617	16	Ana	Ana	NNP
en-wikipedia-org-3485	617	17	;	;	:
en-wikipedia-org-3485	617	18	Borges	Borges	NNP
en-wikipedia-org-3485	617	19	,	,	,
en-wikipedia-org-3485	617	20	Sonia	Sonia	NNP
en-wikipedia-org-3485	617	21	;	;	:
en-wikipedia-org-3485	617	22	Pinto	Pinto	NNP
en-wikipedia-org-3485	617	23	,	,	,
en-wikipedia-org-3485	617	24	Luisa	Luisa	NNP
en-wikipedia-org-3485	617	25	;	;	:
en-wikipedia-org-3485	617	26	Costa	Costa	NNP
en-wikipedia-org-3485	617	27	,	,	,
en-wikipedia-org-3485	617	28	Patricio	Patricio	NNP
en-wikipedia-org-3485	617	29	;	;	:
en-wikipedia-org-3485	617	30	Sousa	Sousa	NNP
en-wikipedia-org-3485	617	31	,	,	,
en-wikipedia-org-3485	617	32	Nuno	Nuno	NNP
en-wikipedia-org-3485	617	33	;	;	:
en-wikipedia-org-3485	617	34	Rodrigues	Rodrigues	NNP
en-wikipedia-org-3485	617	35	,	,	,
en-wikipedia-org-3485	617	36	Ana	Ana	NNP
en-wikipedia-org-3485	617	37	J.	J.	NNP
en-wikipedia-org-3485	618	1	(	(	-LRB-
en-wikipedia-org-3485	618	2	September	September	NNP
en-wikipedia-org-3485	618	3	2016	2016	CD
en-wikipedia-org-3485	618	4	)	)	-RRB-
en-wikipedia-org-3485	618	5	.	.	.
en-wikipedia-org-3485	619	1	"	"	``
en-wikipedia-org-3485	619	2	Activation	Activation	NNP
en-wikipedia-org-3485	619	3	of	of	IN
en-wikipedia-org-3485	619	4	D2	D2	NNP
en-wikipedia-org-3485	619	5	dopamine	dopamine	NN
en-wikipedia-org-3485	619	6	receptor	receptor	NN
en-wikipedia-org-3485	619	7	-	-	HYPH
en-wikipedia-org-3485	619	8	expressing	express	VBG
en-wikipedia-org-3485	619	9	neurons	neuron	NNS
en-wikipedia-org-3485	619	10	in	in	IN
en-wikipedia-org-3485	619	11	the	the	DT
en-wikipedia-org-3485	619	12	nucleus	nucleus	NN
en-wikipedia-org-3485	619	13	accumbens	accumben	VBZ
en-wikipedia-org-3485	619	14	increases	increase	VBZ
en-wikipedia-org-3485	619	15	motivation	motivation	NN
en-wikipedia-org-3485	619	16	"	"	''
en-wikipedia-org-3485	619	17	.	.	.
en-wikipedia-org-3485	620	1	Nature	Nature	NNP
en-wikipedia-org-3485	620	2	Communications	Communications	NNPS
en-wikipedia-org-3485	620	3	.	.	.
en-wikipedia-org-3485	621	1	7	7	CD
en-wikipedia-org-3485	621	2	(	(	-LRB-
en-wikipedia-org-3485	621	3	1	1	CD
en-wikipedia-org-3485	621	4	)	)	-RRB-
en-wikipedia-org-3485	621	5	:	:	:
en-wikipedia-org-3485	621	6	11829	11829	CD
en-wikipedia-org-3485	621	7	.	.	.
en-wikipedia-org-3485	622	1	Bibcode:2016NatCo	Bibcode:2016NatCo	NNP
en-wikipedia-org-3485	622	2	...	...	:
en-wikipedia-org-3485	622	3	711829S.	711829s.	CD
en-wikipedia-org-3485	623	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-3485	623	2	/	/	SYM
en-wikipedia-org-3485	623	3	ncomms11829	ncomms11829	NNP
en-wikipedia-org-3485	623	4	.	.	.
en-wikipedia-org-3485	624	1	PMC	PMC	NNP
en-wikipedia-org-3485	624	2	 	  	_SP
en-wikipedia-org-3485	624	3	4931006	4931006	CD
en-wikipedia-org-3485	624	4	.	.	.
en-wikipedia-org-3485	625	1	PMID	PMID	NNP
en-wikipedia-org-3485	625	2	 	  	_SP
en-wikipedia-org-3485	625	3	27337658	27337658	CD
en-wikipedia-org-3485	625	4	.	.	.
en-wikipedia-org-3485	626	1	^	^	NNP
en-wikipedia-org-3485	626	2	Soares	Soares	NNP
en-wikipedia-org-3485	626	3	-	-	HYPH
en-wikipedia-org-3485	626	4	Cunha	Cunha	NNP
en-wikipedia-org-3485	626	5	,	,	,
en-wikipedia-org-3485	626	6	Carina	Carina	NNP
en-wikipedia-org-3485	626	7	;	;	:
en-wikipedia-org-3485	626	8	Coimbra	Coimbra	NNP
en-wikipedia-org-3485	626	9	,	,	,
en-wikipedia-org-3485	626	10	Bárbara	Bárbara	NNP
en-wikipedia-org-3485	626	11	;	;	:
en-wikipedia-org-3485	626	12	Domingues	Domingues	NNP
en-wikipedia-org-3485	626	13	,	,	,
en-wikipedia-org-3485	626	14	Ana	Ana	NNP
en-wikipedia-org-3485	626	15	Verónica	Verónica	NNP
en-wikipedia-org-3485	626	16	;	;	:
en-wikipedia-org-3485	626	17	Vasconcelos	Vasconcelos	NNP
en-wikipedia-org-3485	626	18	,	,	,
en-wikipedia-org-3485	626	19	Nivaldo	Nivaldo	NNP
en-wikipedia-org-3485	626	20	;	;	:
en-wikipedia-org-3485	626	21	Sousa	Sousa	NNP
en-wikipedia-org-3485	626	22	,	,	,
en-wikipedia-org-3485	626	23	Nuno	Nuno	NNP
en-wikipedia-org-3485	626	24	;	;	:
en-wikipedia-org-3485	626	25	Rodrigues	Rodrigues	NNP
en-wikipedia-org-3485	626	26	,	,	,
en-wikipedia-org-3485	626	27	Ana	Ana	NNP
en-wikipedia-org-3485	626	28	João	João	NNP
en-wikipedia-org-3485	626	29	(	(	-LRB-
en-wikipedia-org-3485	626	30	March	March	NNP
en-wikipedia-org-3485	626	31	2018	2018	CD
en-wikipedia-org-3485	626	32	)	)	-RRB-
en-wikipedia-org-3485	626	33	.	.	.
en-wikipedia-org-3485	627	1	"	"	``
en-wikipedia-org-3485	627	2	Nucleus	Nucleus	NNP
en-wikipedia-org-3485	627	3	Accumbens	Accumbens	NNP
en-wikipedia-org-3485	627	4	Microcircuit	Microcircuit	NNP
en-wikipedia-org-3485	627	5	Underlying	Underlying	NNP
en-wikipedia-org-3485	627	6	D2-MSN	D2-MSN	NNP
en-wikipedia-org-3485	627	7	-	-	HYPH
en-wikipedia-org-3485	627	8	Driven	drive	VBN
en-wikipedia-org-3485	627	9	Increase	Increase	NNP
en-wikipedia-org-3485	627	10	in	in	IN
en-wikipedia-org-3485	627	11	Motivation	Motivation	NNP
en-wikipedia-org-3485	627	12	"	"	''
en-wikipedia-org-3485	627	13	.	.	.
en-wikipedia-org-3485	628	1	eNeuro	eNeuro	NNP
en-wikipedia-org-3485	628	2	.	.	.
en-wikipedia-org-3485	629	1	5	5	CD
en-wikipedia-org-3485	629	2	(	(	-LRB-
en-wikipedia-org-3485	629	3	2	2	CD
en-wikipedia-org-3485	629	4	)	)	-RRB-
en-wikipedia-org-3485	629	5	:	:	:
en-wikipedia-org-3485	629	6	ENEURO.0386–18.2018	ENEURO.0386–18.2018	NNP
en-wikipedia-org-3485	629	7	.	.	.
en-wikipedia-org-3485	630	1	doi:10.1523	doi:10.1523	NNP
en-wikipedia-org-3485	630	2	/	/	SYM
en-wikipedia-org-3485	630	3	ENEURO.0386	ENEURO.0386	NNP
en-wikipedia-org-3485	630	4	-	-	HYPH
en-wikipedia-org-3485	630	5	18.2018	18.2018	CD
en-wikipedia-org-3485	630	6	.	.	.
en-wikipedia-org-3485	631	1	PMC	PMC	NNP
en-wikipedia-org-3485	631	2	 	  	_SP
en-wikipedia-org-3485	631	3	5957524	5957524	CD
en-wikipedia-org-3485	631	4	.	.	.
en-wikipedia-org-3485	632	1	PMID	PMID	NNP
en-wikipedia-org-3485	632	2	 	  	_SP
en-wikipedia-org-3485	632	3	29780881	29780881	CD
en-wikipedia-org-3485	632	4	.	.	.
en-wikipedia-org-3485	633	1	^	^	NNP
en-wikipedia-org-3485	633	2	Koob	Koob	NNP
en-wikipedia-org-3485	633	3	G.	G.	NNP
en-wikipedia-org-3485	633	4	F.	F.	NNP
en-wikipedia-org-3485	633	5	,	,	,
en-wikipedia-org-3485	633	6	Le	Le	NNP
en-wikipedia-org-3485	633	7	Moal	Moal	NNP
en-wikipedia-org-3485	633	8	M.	M.	NNP
en-wikipedia-org-3485	633	9	(	(	-LRB-
en-wikipedia-org-3485	633	10	2008	2008	CD
en-wikipedia-org-3485	633	11	)	)	-RRB-
en-wikipedia-org-3485	633	12	.	.	.
en-wikipedia-org-3485	634	1	Addiction	addiction	NN
en-wikipedia-org-3485	634	2	and	and	CC
en-wikipedia-org-3485	634	3	the	the	DT
en-wikipedia-org-3485	634	4	brain	brain	NN
en-wikipedia-org-3485	634	5	antireward	antireward	NN
en-wikipedia-org-3485	634	6	system	system	NN
en-wikipedia-org-3485	634	7	.	.	.
en-wikipedia-org-3485	635	1	Annu	Annu	NNP
en-wikipedia-org-3485	635	2	.	.	.
en-wikipedia-org-3485	636	1	Rev.	Rev.	NNP
en-wikipedia-org-3485	637	1	Psychol	Psychol	NNP
en-wikipedia-org-3485	637	2	.	.	.
en-wikipedia-org-3485	638	1	59	59	CD
en-wikipedia-org-3485	638	2	29–53	29–53	CD
en-wikipedia-org-3485	638	3	.	.	.
en-wikipedia-org-3485	639	1	10.1146	10.1146	CD
en-wikipedia-org-3485	639	2	/	/	SYM
en-wikipedia-org-3485	639	3	annurev.psych.59.103006.093548	annurev.psych.59.103006.093548	NNP
en-wikipedia-org-3485	639	4	[	[	-LRB-
en-wikipedia-org-3485	639	5	PubMed	pubmed	NN
en-wikipedia-org-3485	639	6	]	]	-RRB-
en-wikipedia-org-3485	639	7	[	[	-LRB-
en-wikipedia-org-3485	639	8	CrossRef	CrossRef	NNP
en-wikipedia-org-3485	639	9	]	]	-RRB-
en-wikipedia-org-3485	639	10	[	[	-LRB-
en-wikipedia-org-3485	639	11	Google	Google	NNP
en-wikipedia-org-3485	639	12	Scholar	Scholar	NNP
en-wikipedia-org-3485	639	13	]	]	-RRB-
en-wikipedia-org-3485	639	14	Koob	Koob	NNP
en-wikipedia-org-3485	639	15	G.	G.	NNP
en-wikipedia-org-3485	639	16	F.	F.	NNP
en-wikipedia-org-3485	639	17	,	,	,
en-wikipedia-org-3485	639	18	Sanna	Sanna	NNP
en-wikipedia-org-3485	639	19	P.	P.	NNP
en-wikipedia-org-3485	639	20	P.	P.	NNP
en-wikipedia-org-3485	639	21	,	,	,
en-wikipedia-org-3485	639	22	Bloom	Bloom	NNP
en-wikipedia-org-3485	639	23	F.	F.	NNP
en-wikipedia-org-3485	639	24	E.	E.	NNP
en-wikipedia-org-3485	639	25	(	(	-LRB-
en-wikipedia-org-3485	639	26	1998	1998	CD
en-wikipedia-org-3485	639	27	)	)	-RRB-
en-wikipedia-org-3485	639	28	.	.	.
en-wikipedia-org-3485	640	1	Neuroscience	neuroscience	NN
en-wikipedia-org-3485	640	2	of	of	IN
en-wikipedia-org-3485	640	3	addiction	addiction	NN
en-wikipedia-org-3485	640	4	.	.	.
en-wikipedia-org-3485	641	1	Neuron	Neuron	NNP
en-wikipedia-org-3485	641	2	21	21	CD
en-wikipedia-org-3485	641	3	467–476	467–476	CD
en-wikipedia-org-3485	641	4	^	^	NN
en-wikipedia-org-3485	641	5	Meyer	Meyer	NNP
en-wikipedia-org-3485	641	6	,	,	,
en-wikipedia-org-3485	641	7	J.	J.	NNP
en-wikipedia-org-3485	641	8	S.	S.	NNP
en-wikipedia-org-3485	641	9	,	,	,
en-wikipedia-org-3485	641	10	&	&	CC
en-wikipedia-org-3485	641	11	Quenzer	Quenzer	NNP
en-wikipedia-org-3485	641	12	,	,	,
en-wikipedia-org-3485	641	13	L.	L.	NNP
en-wikipedia-org-3485	641	14	F.	F.	NNP
en-wikipedia-org-3485	641	15	(	(	-LRB-
en-wikipedia-org-3485	641	16	2013	2013	CD
en-wikipedia-org-3485	641	17	)	)	-RRB-
en-wikipedia-org-3485	641	18	.	.	.
en-wikipedia-org-3485	642	1	Psychopharmacology	psychopharmacology	NN
en-wikipedia-org-3485	642	2	:	:	:
en-wikipedia-org-3485	642	3	Drugs	drug	NNS
en-wikipedia-org-3485	642	4	,	,	,
en-wikipedia-org-3485	642	5	the	the	DT
en-wikipedia-org-3485	642	6	brain	brain	NN
en-wikipedia-org-3485	642	7	,	,	,
en-wikipedia-org-3485	642	8	and	and	CC
en-wikipedia-org-3485	642	9	behavior	behavior	NN
en-wikipedia-org-3485	642	10	.	.	.
en-wikipedia-org-3485	643	1	Sinauer	Sinauer	NNP
en-wikipedia-org-3485	643	2	Associates	Associates	NNPS
en-wikipedia-org-3485	643	3	.	.	.
en-wikipedia-org-3485	644	1	^	^	NNP
en-wikipedia-org-3485	644	2	a	a	DT
en-wikipedia-org-3485	644	3	b	b	NN
en-wikipedia-org-3485	644	4	Yin	Yin	NNP
en-wikipedia-org-3485	644	5	,	,	,
en-wikipedia-org-3485	644	6	HH	HH	NNP
en-wikipedia-org-3485	644	7	;	;	:
en-wikipedia-org-3485	644	8	Ostlund	Ostlund	NNP
en-wikipedia-org-3485	644	9	,	,	,
en-wikipedia-org-3485	644	10	SB	SB	NNP
en-wikipedia-org-3485	644	11	;	;	:
en-wikipedia-org-3485	644	12	Balleine	Balleine	NNP
en-wikipedia-org-3485	644	13	,	,	,
en-wikipedia-org-3485	644	14	BW	BW	NNP
en-wikipedia-org-3485	644	15	(	(	-LRB-
en-wikipedia-org-3485	644	16	October	October	NNP
en-wikipedia-org-3485	644	17	2008	2008	CD
en-wikipedia-org-3485	644	18	)	)	-RRB-
en-wikipedia-org-3485	644	19	.	.	.
en-wikipedia-org-3485	645	1	"	"	``
en-wikipedia-org-3485	645	2	Reward	reward	NN
en-wikipedia-org-3485	645	3	-	-	HYPH
en-wikipedia-org-3485	645	4	guided	guide	VBN
en-wikipedia-org-3485	645	5	learning	learning	NN
en-wikipedia-org-3485	645	6	beyond	beyond	IN
en-wikipedia-org-3485	645	7	dopamine	dopamine	NN
en-wikipedia-org-3485	645	8	in	in	IN
en-wikipedia-org-3485	645	9	the	the	DT
en-wikipedia-org-3485	645	10	nucleus	nucleus	NN
en-wikipedia-org-3485	645	11	accumbens	accumben	VBZ
en-wikipedia-org-3485	645	12	:	:	:
en-wikipedia-org-3485	645	13	the	the	DT
en-wikipedia-org-3485	645	14	integrative	integrative	JJ
en-wikipedia-org-3485	645	15	functions	function	NNS
en-wikipedia-org-3485	645	16	of	of	IN
en-wikipedia-org-3485	645	17	cortico	cortico	NNP
en-wikipedia-org-3485	645	18	-	-	HYPH
en-wikipedia-org-3485	645	19	basal	basal	NNP
en-wikipedia-org-3485	645	20	ganglia	ganglia	NNP
en-wikipedia-org-3485	645	21	networks	networks	NNP
en-wikipedia-org-3485	645	22	"	"	''
en-wikipedia-org-3485	645	23	.	.	.
en-wikipedia-org-3485	646	1	The	the	DT
en-wikipedia-org-3485	646	2	European	European	NNP
en-wikipedia-org-3485	646	3	Journal	Journal	NNP
en-wikipedia-org-3485	646	4	of	of	IN
en-wikipedia-org-3485	646	5	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	646	6	.	.	.
en-wikipedia-org-3485	647	1	28	28	CD
en-wikipedia-org-3485	647	2	(	(	-LRB-
en-wikipedia-org-3485	647	3	8)	8)	CD
en-wikipedia-org-3485	647	4	:	:	:
en-wikipedia-org-3485	647	5	1437–48	1437–48	CD
en-wikipedia-org-3485	647	6	.	.	.
en-wikipedia-org-3485	648	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-3485	648	2	/	/	SYM
en-wikipedia-org-3485	648	3	j.1460	j.1460	NNP
en-wikipedia-org-3485	648	4	-	-	HYPH
en-wikipedia-org-3485	648	5	9568.2008.06422.x	9568.2008.06422.x	CD
en-wikipedia-org-3485	648	6	.	.	.
en-wikipedia-org-3485	649	1	PMC	PMC	NNP
en-wikipedia-org-3485	649	2	 	  	_SP
en-wikipedia-org-3485	649	3	2756656	2756656	CD
en-wikipedia-org-3485	649	4	.	.	.
en-wikipedia-org-3485	650	1	PMID	PMID	NNP
en-wikipedia-org-3485	650	2	 	  	_SP
en-wikipedia-org-3485	650	3	18793321	18793321	CD
en-wikipedia-org-3485	650	4	.	.	.
en-wikipedia-org-3485	651	1	^	^	NNP
en-wikipedia-org-3485	651	2	Dayan	Dayan	NNP
en-wikipedia-org-3485	651	3	,	,	,
en-wikipedia-org-3485	651	4	P	p	NN
en-wikipedia-org-3485	651	5	;	;	:
en-wikipedia-org-3485	651	6	Berridge	Berridge	NNP
en-wikipedia-org-3485	651	7	,	,	,
en-wikipedia-org-3485	651	8	KC	KC	NNP
en-wikipedia-org-3485	651	9	(	(	-LRB-
en-wikipedia-org-3485	651	10	June	June	NNP
en-wikipedia-org-3485	651	11	2014	2014	CD
en-wikipedia-org-3485	651	12	)	)	-RRB-
en-wikipedia-org-3485	651	13	.	.	.
en-wikipedia-org-3485	652	1	"	"	``
en-wikipedia-org-3485	652	2	Model	model	NN
en-wikipedia-org-3485	652	3	-	-	HYPH
en-wikipedia-org-3485	652	4	based	base	VBN
en-wikipedia-org-3485	652	5	and	and	CC
en-wikipedia-org-3485	652	6	model	model	NN
en-wikipedia-org-3485	652	7	-	-	HYPH
en-wikipedia-org-3485	652	8	free	free	JJ
en-wikipedia-org-3485	652	9	Pavlovian	pavlovian	JJ
en-wikipedia-org-3485	652	10	reward	reward	NN
en-wikipedia-org-3485	652	11	learning	learning	NN
en-wikipedia-org-3485	652	12	:	:	:
en-wikipedia-org-3485	652	13	revaluation	revaluation	NN
en-wikipedia-org-3485	652	14	,	,	,
en-wikipedia-org-3485	652	15	revision	revision	NN
en-wikipedia-org-3485	652	16	,	,	,
en-wikipedia-org-3485	652	17	and	and	CC
en-wikipedia-org-3485	652	18	revelation	revelation	NN
en-wikipedia-org-3485	652	19	"	"	''
en-wikipedia-org-3485	652	20	.	.	.
en-wikipedia-org-3485	653	1	Cognitive	Cognitive	NNP
en-wikipedia-org-3485	653	2	,	,	,
en-wikipedia-org-3485	653	3	Affective	affective	JJ
en-wikipedia-org-3485	653	4	,	,	,
en-wikipedia-org-3485	653	5	&	&	CC
en-wikipedia-org-3485	653	6	Behavioral	Behavioral	NNP
en-wikipedia-org-3485	653	7	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	653	8	.	.	.
en-wikipedia-org-3485	654	1	14	14	CD
en-wikipedia-org-3485	654	2	(	(	-LRB-
en-wikipedia-org-3485	654	3	2	2	CD
en-wikipedia-org-3485	654	4	)	)	-RRB-
en-wikipedia-org-3485	654	5	:	:	:
en-wikipedia-org-3485	654	6	473–92	473–92	CD
en-wikipedia-org-3485	654	7	.	.	.
en-wikipedia-org-3485	655	1	doi:10.3758	doi:10.3758	NNP
en-wikipedia-org-3485	655	2	/	/	SYM
en-wikipedia-org-3485	655	3	s13415	s13415	NNP
en-wikipedia-org-3485	655	4	-	-	HYPH
en-wikipedia-org-3485	655	5	014	014	CD
en-wikipedia-org-3485	655	6	-	-	HYPH
en-wikipedia-org-3485	655	7	0277	0277	CD
en-wikipedia-org-3485	655	8	-	-	HYPH
en-wikipedia-org-3485	655	9	8	8	CD
en-wikipedia-org-3485	655	10	.	.	.
en-wikipedia-org-3485	656	1	PMC	PMC	NNP
en-wikipedia-org-3485	656	2	 	  	_SP
en-wikipedia-org-3485	656	3	4074442	4074442	CD
en-wikipedia-org-3485	656	4	.	.	.
en-wikipedia-org-3485	657	1	PMID	PMID	NNP
en-wikipedia-org-3485	657	2	 	  	_SP
en-wikipedia-org-3485	657	3	24647659	24647659	CD
en-wikipedia-org-3485	657	4	.	.	.
en-wikipedia-org-3485	658	1	^	^	NNP
en-wikipedia-org-3485	658	2	Balleine	Balleine	NNP
en-wikipedia-org-3485	658	3	,	,	,
en-wikipedia-org-3485	658	4	BW	BW	NNP
en-wikipedia-org-3485	658	5	;	;	:
en-wikipedia-org-3485	658	6	Morris	Morris	NNP
en-wikipedia-org-3485	658	7	,	,	,
en-wikipedia-org-3485	658	8	RW	RW	NNP
en-wikipedia-org-3485	658	9	;	;	:
en-wikipedia-org-3485	658	10	Leung	Leung	NNP
en-wikipedia-org-3485	658	11	,	,	,
en-wikipedia-org-3485	658	12	BK	BK	NNP
en-wikipedia-org-3485	658	13	(	(	-LRB-
en-wikipedia-org-3485	658	14	2	2	CD
en-wikipedia-org-3485	658	15	December	December	NNP
en-wikipedia-org-3485	658	16	2015	2015	CD
en-wikipedia-org-3485	658	17	)	)	-RRB-
en-wikipedia-org-3485	658	18	.	.	.
en-wikipedia-org-3485	659	1	"	"	``
en-wikipedia-org-3485	659	2	Thalamocortical	thalamocortical	JJ
en-wikipedia-org-3485	659	3	integration	integration	NN
en-wikipedia-org-3485	659	4	of	of	IN
en-wikipedia-org-3485	659	5	instrumental	instrumental	JJ
en-wikipedia-org-3485	659	6	learning	learning	NN
en-wikipedia-org-3485	659	7	and	and	CC
en-wikipedia-org-3485	659	8	performance	performance	NN
en-wikipedia-org-3485	659	9	and	and	CC
en-wikipedia-org-3485	659	10	their	-PRON-	PRP$
en-wikipedia-org-3485	659	11	disintegration	disintegration	NN
en-wikipedia-org-3485	659	12	in	in	IN
en-wikipedia-org-3485	659	13	addiction	addiction	NN
en-wikipedia-org-3485	659	14	"	"	''
en-wikipedia-org-3485	659	15	.	.	.
en-wikipedia-org-3485	660	1	Brain	Brain	NNP
en-wikipedia-org-3485	660	2	Research	Research	NNP
en-wikipedia-org-3485	660	3	.	.	.
en-wikipedia-org-3485	661	1	1628	1628	CD
en-wikipedia-org-3485	661	2	(	(	-LRB-
en-wikipedia-org-3485	661	3	Pt	Pt	NNP
en-wikipedia-org-3485	661	4	A	A	NNP
en-wikipedia-org-3485	661	5	)	)	-RRB-
en-wikipedia-org-3485	661	6	:	:	:
en-wikipedia-org-3485	661	7	104–16	104–16	CD
en-wikipedia-org-3485	661	8	.	.	.
en-wikipedia-org-3485	662	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	662	2	/	/	SYM
en-wikipedia-org-3485	662	3	j.brainres.2014.12.023	j.brainres.2014.12.023	NN
en-wikipedia-org-3485	662	4	.	.	.
en-wikipedia-org-3485	663	1	PMID	PMID	NNP
en-wikipedia-org-3485	663	2	 	  	_SP
en-wikipedia-org-3485	663	3	25514336	25514336	CD
en-wikipedia-org-3485	663	4	.	.	.
en-wikipedia-org-3485	664	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	664	2	 	  	_SP
en-wikipedia-org-3485	664	3	11776683	11776683	CD
en-wikipedia-org-3485	664	4	.	.	.
en-wikipedia-org-3485	665	1	Importantly	importantly	RB
en-wikipedia-org-3485	665	2	,	,	,
en-wikipedia-org-3485	665	3	we	-PRON-	PRP
en-wikipedia-org-3485	665	4	found	find	VBD
en-wikipedia-org-3485	665	5	evidence	evidence	NN
en-wikipedia-org-3485	665	6	of	of	IN
en-wikipedia-org-3485	665	7	increased	increase	VBN
en-wikipedia-org-3485	665	8	activity	activity	NN
en-wikipedia-org-3485	665	9	in	in	IN
en-wikipedia-org-3485	665	10	the	the	DT
en-wikipedia-org-3485	665	11	direct	direct	JJ
en-wikipedia-org-3485	665	12	pathway	pathway	NN
en-wikipedia-org-3485	665	13	;	;	:
en-wikipedia-org-3485	665	14	both	both	DT
en-wikipedia-org-3485	665	15	intracellular	intracellular	JJ
en-wikipedia-org-3485	665	16	changes	change	NNS
en-wikipedia-org-3485	665	17	in	in	IN
en-wikipedia-org-3485	665	18	the	the	DT
en-wikipedia-org-3485	665	19	expression	expression	NN
en-wikipedia-org-3485	665	20	of	of	IN
en-wikipedia-org-3485	665	21	the	the	DT
en-wikipedia-org-3485	665	22	plasticity	plasticity	NN
en-wikipedia-org-3485	665	23	marker	marker	NN
en-wikipedia-org-3485	665	24	pERK	perk	NN
en-wikipedia-org-3485	665	25	and	and	CC
en-wikipedia-org-3485	665	26	AMPA	AMPA	NNP
en-wikipedia-org-3485	665	27	/	/	SYM
en-wikipedia-org-3485	665	28	NMDA	NMDA	NNP
en-wikipedia-org-3485	665	29	ratios	ratio	NNS
en-wikipedia-org-3485	665	30	evoked	evoke	VBN
en-wikipedia-org-3485	665	31	by	by	IN
en-wikipedia-org-3485	665	32	stimulating	stimulate	VBG
en-wikipedia-org-3485	665	33	cortical	cortical	JJ
en-wikipedia-org-3485	665	34	afferents	afferent	NNS
en-wikipedia-org-3485	665	35	were	be	VBD
en-wikipedia-org-3485	665	36	increased	increase	VBN
en-wikipedia-org-3485	665	37	in	in	IN
en-wikipedia-org-3485	665	38	the	the	DT
en-wikipedia-org-3485	665	39	D1-direct	d1-direct	JJ
en-wikipedia-org-3485	665	40	pathway	pathway	JJ
en-wikipedia-org-3485	665	41	neurons	neuron	NNS
en-wikipedia-org-3485	665	42	.	.	.
en-wikipedia-org-3485	666	1	In	in	IN
en-wikipedia-org-3485	666	2	contrast	contrast	NN
en-wikipedia-org-3485	666	3	,	,	,
en-wikipedia-org-3485	666	4	D2	D2	NNP
en-wikipedia-org-3485	666	5	neurons	neuron	NNS
en-wikipedia-org-3485	666	6	showed	show	VBD
en-wikipedia-org-3485	666	7	an	an	DT
en-wikipedia-org-3485	666	8	opposing	oppose	VBG
en-wikipedia-org-3485	666	9	change	change	NN
en-wikipedia-org-3485	666	10	in	in	IN
en-wikipedia-org-3485	666	11	plasticity	plasticity	NN
en-wikipedia-org-3485	666	12	;	;	,
en-wikipedia-org-3485	666	13	stimulation	stimulation	NN
en-wikipedia-org-3485	666	14	of	of	IN
en-wikipedia-org-3485	666	15	cortical	cortical	JJ
en-wikipedia-org-3485	666	16	afferents	afferent	NNS
en-wikipedia-org-3485	666	17	reduced	reduce	VBD
en-wikipedia-org-3485	666	18	AMPA	AMPA	NNP
en-wikipedia-org-3485	666	19	/	/	SYM
en-wikipedia-org-3485	666	20	NMDA	NMDA	NNP
en-wikipedia-org-3485	666	21	ratios	ratio	VBZ
en-wikipedia-org-3485	666	22	on	on	IN
en-wikipedia-org-3485	666	23	those	those	DT
en-wikipedia-org-3485	666	24	neurons	neuron	NNS
en-wikipedia-org-3485	666	25	(	(	-LRB-
en-wikipedia-org-3485	666	26	Shan	Shan	NNP
en-wikipedia-org-3485	666	27	et	et	FW
en-wikipedia-org-3485	666	28	al	al	NNP
en-wikipedia-org-3485	666	29	.	.	NNP
en-wikipedia-org-3485	666	30	,	,	,
en-wikipedia-org-3485	666	31	2014	2014	CD
en-wikipedia-org-3485	666	32	)	)	-RRB-
en-wikipedia-org-3485	666	33	.	.	.
en-wikipedia-org-3485	667	1	^	^	NNP
en-wikipedia-org-3485	667	2	Nakanishi	Nakanishi	NNP
en-wikipedia-org-3485	667	3	,	,	,
en-wikipedia-org-3485	667	4	S	S	NNP
en-wikipedia-org-3485	667	5	;	;	:
en-wikipedia-org-3485	667	6	Hikida	Hikida	NNP
en-wikipedia-org-3485	667	7	,	,	,
en-wikipedia-org-3485	667	8	T	T	NNP
en-wikipedia-org-3485	667	9	;	;	:
en-wikipedia-org-3485	667	10	Yawata	Yawata	NNP
en-wikipedia-org-3485	667	11	,	,	,
en-wikipedia-org-3485	667	12	S	S	NNP
en-wikipedia-org-3485	667	13	(	(	-LRB-
en-wikipedia-org-3485	667	14	12	12	CD
en-wikipedia-org-3485	667	15	December	December	NNP
en-wikipedia-org-3485	667	16	2014	2014	CD
en-wikipedia-org-3485	667	17	)	)	-RRB-
en-wikipedia-org-3485	667	18	.	.	.
en-wikipedia-org-3485	668	1	"	"	``
en-wikipedia-org-3485	668	2	Distinct	distinct	JJ
en-wikipedia-org-3485	668	3	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	668	4	control	control	NN
en-wikipedia-org-3485	668	5	of	of	IN
en-wikipedia-org-3485	668	6	the	the	DT
en-wikipedia-org-3485	668	7	direct	direct	JJ
en-wikipedia-org-3485	668	8	and	and	CC
en-wikipedia-org-3485	668	9	indirect	indirect	JJ
en-wikipedia-org-3485	668	10	pathways	pathway	NNS
en-wikipedia-org-3485	668	11	in	in	IN
en-wikipedia-org-3485	668	12	reward	reward	NN
en-wikipedia-org-3485	668	13	-	-	HYPH
en-wikipedia-org-3485	668	14	based	base	VBN
en-wikipedia-org-3485	668	15	and	and	CC
en-wikipedia-org-3485	668	16	avoidance	avoidance	NN
en-wikipedia-org-3485	668	17	learning	learning	NN
en-wikipedia-org-3485	668	18	behaviors	behavior	NNS
en-wikipedia-org-3485	668	19	"	"	''
en-wikipedia-org-3485	668	20	.	.	.
en-wikipedia-org-3485	669	1	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	669	2	.	.	.
en-wikipedia-org-3485	670	1	282	282	CD
en-wikipedia-org-3485	670	2	:	:	:
en-wikipedia-org-3485	670	3	49–59	49–59	CD
en-wikipedia-org-3485	670	4	.	.	.
en-wikipedia-org-3485	671	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	671	2	/	/	SYM
en-wikipedia-org-3485	671	3	j.neuroscience.2014.04.026	j.neuroscience.2014.04.026	CD
en-wikipedia-org-3485	671	4	.	.	.
en-wikipedia-org-3485	672	1	PMID	PMID	NNP
en-wikipedia-org-3485	672	2	 	  	_SP
en-wikipedia-org-3485	672	3	24769227	24769227	CD
en-wikipedia-org-3485	672	4	.	.	.
en-wikipedia-org-3485	673	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	673	2	 	  	_SP
en-wikipedia-org-3485	673	3	21652525	21652525	CD
en-wikipedia-org-3485	673	4	.	.	.
en-wikipedia-org-3485	674	1	^	^	NNP
en-wikipedia-org-3485	674	2	Shiflett	Shiflett	NNP
en-wikipedia-org-3485	674	3	,	,	,
en-wikipedia-org-3485	674	4	MW	MW	NNP
en-wikipedia-org-3485	674	5	;	;	:
en-wikipedia-org-3485	674	6	Balleine	Balleine	NNP
en-wikipedia-org-3485	674	7	,	,	,
en-wikipedia-org-3485	674	8	BW	BW	NNP
en-wikipedia-org-3485	674	9	(	(	-LRB-
en-wikipedia-org-3485	674	10	15	15	CD
en-wikipedia-org-3485	674	11	September	September	NNP
en-wikipedia-org-3485	674	12	2011	2011	CD
en-wikipedia-org-3485	674	13	)	)	-RRB-
en-wikipedia-org-3485	674	14	.	.	.
en-wikipedia-org-3485	675	1	"	"	``
en-wikipedia-org-3485	675	2	Molecular	molecular	JJ
en-wikipedia-org-3485	675	3	substrates	substrate	NNS
en-wikipedia-org-3485	675	4	of	of	IN
en-wikipedia-org-3485	675	5	action	action	NN
en-wikipedia-org-3485	675	6	control	control	NN
en-wikipedia-org-3485	675	7	in	in	IN
en-wikipedia-org-3485	675	8	cortico	cortico	NNP
en-wikipedia-org-3485	675	9	-	-	HYPH
en-wikipedia-org-3485	675	10	striatal	striatal	JJ
en-wikipedia-org-3485	675	11	circuits	circuit	NNS
en-wikipedia-org-3485	675	12	"	"	''
en-wikipedia-org-3485	675	13	.	.	.
en-wikipedia-org-3485	676	1	Progress	progress	NN
en-wikipedia-org-3485	676	2	in	in	IN
en-wikipedia-org-3485	676	3	Neurobiology	Neurobiology	NNP
en-wikipedia-org-3485	676	4	.	.	.
en-wikipedia-org-3485	677	1	95	95	CD
en-wikipedia-org-3485	677	2	(	(	-LRB-
en-wikipedia-org-3485	677	3	1	1	CD
en-wikipedia-org-3485	677	4	)	)	-RRB-
en-wikipedia-org-3485	677	5	:	:	:
en-wikipedia-org-3485	677	6	1–13	1–13	ADD
en-wikipedia-org-3485	677	7	.	.	.
en-wikipedia-org-3485	678	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	678	2	/	/	SYM
en-wikipedia-org-3485	678	3	j.pneurobio.2011.05.007	j.pneurobio.2011.05.007	NN
en-wikipedia-org-3485	678	4	.	.	.
en-wikipedia-org-3485	679	1	PMC	PMC	NNP
en-wikipedia-org-3485	679	2	 	  	_SP
en-wikipedia-org-3485	679	3	3175490	3175490	CD
en-wikipedia-org-3485	679	4	.	.	.
en-wikipedia-org-3485	680	1	PMID	PMID	NNP
en-wikipedia-org-3485	680	2	 	  	_SP
en-wikipedia-org-3485	680	3	21704115	21704115	CD
en-wikipedia-org-3485	680	4	.	.	.
en-wikipedia-org-3485	681	1	^	^	NNP
en-wikipedia-org-3485	681	2	Schultz	Schultz	NNP
en-wikipedia-org-3485	681	3	,	,	,
en-wikipedia-org-3485	681	4	W	W	NNP
en-wikipedia-org-3485	681	5	(	(	-LRB-
en-wikipedia-org-3485	681	6	April	April	NNP
en-wikipedia-org-3485	681	7	2013	2013	CD
en-wikipedia-org-3485	681	8	)	)	-RRB-
en-wikipedia-org-3485	681	9	.	.	.
en-wikipedia-org-3485	682	1	"	"	``
en-wikipedia-org-3485	682	2	Updating	update	VBG
en-wikipedia-org-3485	682	3	dopamine	dopamine	NN
en-wikipedia-org-3485	682	4	reward	reward	NN
en-wikipedia-org-3485	682	5	signals	signal	NNS
en-wikipedia-org-3485	682	6	"	"	''
en-wikipedia-org-3485	682	7	.	.	.
en-wikipedia-org-3485	683	1	Current	current	JJ
en-wikipedia-org-3485	683	2	Opinion	Opinion	NNP
en-wikipedia-org-3485	683	3	in	in	IN
en-wikipedia-org-3485	683	4	Neurobiology	Neurobiology	NNP
en-wikipedia-org-3485	683	5	.	.	.
en-wikipedia-org-3485	684	1	23	23	CD
en-wikipedia-org-3485	684	2	(	(	-LRB-
en-wikipedia-org-3485	684	3	2	2	CD
en-wikipedia-org-3485	684	4	)	)	-RRB-
en-wikipedia-org-3485	684	5	:	:	:
en-wikipedia-org-3485	684	6	229–38	229–38	CD
en-wikipedia-org-3485	684	7	.	.	.
en-wikipedia-org-3485	685	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	685	2	/	/	SYM
en-wikipedia-org-3485	685	3	j.conb.2012.11.012	j.conb.2012.11.012	NNS
en-wikipedia-org-3485	685	4	.	.	.
en-wikipedia-org-3485	686	1	PMC	PMC	NNP
en-wikipedia-org-3485	686	2	 	  	_SP
en-wikipedia-org-3485	686	3	3866681	3866681	CD
en-wikipedia-org-3485	686	4	.	.	.
en-wikipedia-org-3485	687	1	PMID	PMID	NNP
en-wikipedia-org-3485	687	2	 	  	_SP
en-wikipedia-org-3485	687	3	23267662	23267662	CD
en-wikipedia-org-3485	687	4	.	.	.
en-wikipedia-org-3485	688	1	^	^	NNP
en-wikipedia-org-3485	688	2	Shiflett	Shiflett	NNP
en-wikipedia-org-3485	688	3	,	,	,
en-wikipedia-org-3485	688	4	MW	MW	NNP
en-wikipedia-org-3485	688	5	;	;	:
en-wikipedia-org-3485	688	6	Balleine	Balleine	NNP
en-wikipedia-org-3485	688	7	,	,	,
en-wikipedia-org-3485	688	8	BW	BW	NNP
en-wikipedia-org-3485	688	9	(	(	-LRB-
en-wikipedia-org-3485	688	10	17	17	CD
en-wikipedia-org-3485	688	11	March	March	NNP
en-wikipedia-org-3485	688	12	2011	2011	CD
en-wikipedia-org-3485	688	13	)	)	-RRB-
en-wikipedia-org-3485	688	14	.	.	.
en-wikipedia-org-3485	689	1	"	"	``
en-wikipedia-org-3485	689	2	Contributions	contribution	NNS
en-wikipedia-org-3485	689	3	of	of	IN
en-wikipedia-org-3485	689	4	ERK	ERK	NNP
en-wikipedia-org-3485	689	5	signaling	signal	VBG
en-wikipedia-org-3485	689	6	in	in	IN
en-wikipedia-org-3485	689	7	the	the	DT
en-wikipedia-org-3485	689	8	striatum	striatum	NN
en-wikipedia-org-3485	689	9	to	to	IN
en-wikipedia-org-3485	689	10	instrumental	instrumental	JJ
en-wikipedia-org-3485	689	11	learning	learning	NN
en-wikipedia-org-3485	689	12	and	and	CC
en-wikipedia-org-3485	689	13	performance	performance	NN
en-wikipedia-org-3485	689	14	"	"	''
en-wikipedia-org-3485	689	15	.	.	.
en-wikipedia-org-3485	690	1	Behavioural	Behavioural	NNP
en-wikipedia-org-3485	690	2	Brain	Brain	NNP
en-wikipedia-org-3485	690	3	Research	Research	NNP
en-wikipedia-org-3485	690	4	.	.	.
en-wikipedia-org-3485	691	1	218	218	CD
en-wikipedia-org-3485	691	2	(	(	-LRB-
en-wikipedia-org-3485	691	3	1	1	CD
en-wikipedia-org-3485	691	4	)	)	-RRB-
en-wikipedia-org-3485	691	5	:	:	:
en-wikipedia-org-3485	691	6	240–7	240–7	CD
en-wikipedia-org-3485	691	7	.	.	.
en-wikipedia-org-3485	692	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	692	2	/	/	SYM
en-wikipedia-org-3485	692	3	j.bbr.2010.12.010	j.bbr.2010.12.010	NNP
en-wikipedia-org-3485	692	4	.	.	.
en-wikipedia-org-3485	693	1	PMC	PMC	NNP
en-wikipedia-org-3485	693	2	 	  	_SP
en-wikipedia-org-3485	693	3	3022085	3022085	CD
en-wikipedia-org-3485	693	4	.	.	.
en-wikipedia-org-3485	694	1	PMID	PMID	NNP
en-wikipedia-org-3485	694	2	 	  	_SP
en-wikipedia-org-3485	694	3	21147168	21147168	CD
en-wikipedia-org-3485	694	4	.	.	.
en-wikipedia-org-3485	695	1	^	^	NNP
en-wikipedia-org-3485	695	2	a	a	DT
en-wikipedia-org-3485	695	3	b	b	NNP
en-wikipedia-org-3485	695	4	Ruffle	Ruffle	NNP
en-wikipedia-org-3485	695	5	JK	JK	NNP
en-wikipedia-org-3485	695	6	(	(	-LRB-
en-wikipedia-org-3485	695	7	November	November	NNP
en-wikipedia-org-3485	695	8	2014	2014	CD
en-wikipedia-org-3485	695	9	)	)	-RRB-
en-wikipedia-org-3485	695	10	.	.	.
en-wikipedia-org-3485	696	1	"	"	``
en-wikipedia-org-3485	696	2	Molecular	molecular	JJ
en-wikipedia-org-3485	696	3	neurobiology	neurobiology	NN
en-wikipedia-org-3485	696	4	of	of	IN
en-wikipedia-org-3485	696	5	addiction	addiction	NN
en-wikipedia-org-3485	696	6	:	:	:
en-wikipedia-org-3485	696	7	what	what	WP
en-wikipedia-org-3485	696	8	's	be	VBZ
en-wikipedia-org-3485	696	9	all	all	PDT
en-wikipedia-org-3485	696	10	the	the	DT
en-wikipedia-org-3485	696	11	(	(	-LRB-
en-wikipedia-org-3485	696	12	Δ)FosB	Δ)FosB	NNP
en-wikipedia-org-3485	696	13	about	about	IN
en-wikipedia-org-3485	696	14	?	?	.
en-wikipedia-org-3485	696	15	"	"	''
en-wikipedia-org-3485	696	16	.	.	.
en-wikipedia-org-3485	697	1	Am	Am	NNP
en-wikipedia-org-3485	697	2	.	.	.
en-wikipedia-org-3485	698	1	J.	J.	NNP
en-wikipedia-org-3485	699	1	Drug	Drug	NNP
en-wikipedia-org-3485	699	2	Alcohol	Alcohol	NNP
en-wikipedia-org-3485	699	3	Abuse	Abuse	NNP
en-wikipedia-org-3485	699	4	.	.	.
en-wikipedia-org-3485	700	1	40	40	CD
en-wikipedia-org-3485	700	2	(	(	-LRB-
en-wikipedia-org-3485	700	3	6	6	CD
en-wikipedia-org-3485	700	4	)	)	-RRB-
en-wikipedia-org-3485	700	5	:	:	:
en-wikipedia-org-3485	700	6	428–437	428–437	CD
en-wikipedia-org-3485	700	7	.	.	.
en-wikipedia-org-3485	701	1	doi:10.3109/00952990.2014.933840	doi:10.3109/00952990.2014.933840	NNP
en-wikipedia-org-3485	701	2	.	.	.
en-wikipedia-org-3485	702	1	PMID	PMID	NNP
en-wikipedia-org-3485	702	2	 	  	_SP
en-wikipedia-org-3485	702	3	25083822	25083822	CD
en-wikipedia-org-3485	702	4	.	.	.
en-wikipedia-org-3485	703	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	703	2	 	  	_SP
en-wikipedia-org-3485	703	3	19157711	19157711	CD
en-wikipedia-org-3485	703	4	.	.	.
en-wikipedia-org-3485	704	1	The	the	DT
en-wikipedia-org-3485	704	2	strong	strong	JJ
en-wikipedia-org-3485	704	3	correlation	correlation	NN
en-wikipedia-org-3485	704	4	between	between	IN
en-wikipedia-org-3485	704	5	chronic	chronic	JJ
en-wikipedia-org-3485	704	6	drug	drug	NN
en-wikipedia-org-3485	704	7	exposure	exposure	NN
en-wikipedia-org-3485	704	8	and	and	CC
en-wikipedia-org-3485	704	9	ΔFosB	δfosb	NN
en-wikipedia-org-3485	704	10	provides	provide	VBZ
en-wikipedia-org-3485	704	11	novel	novel	JJ
en-wikipedia-org-3485	704	12	opportunities	opportunity	NNS
en-wikipedia-org-3485	704	13	for	for	IN
en-wikipedia-org-3485	704	14	targeted	targeted	JJ
en-wikipedia-org-3485	704	15	therapies	therapy	NNS
en-wikipedia-org-3485	704	16	in	in	IN
en-wikipedia-org-3485	704	17	addiction	addiction	NN
en-wikipedia-org-3485	704	18	(	(	-LRB-
en-wikipedia-org-3485	704	19	118	118	CD
en-wikipedia-org-3485	704	20	)	)	-RRB-
en-wikipedia-org-3485	704	21	,	,	,
en-wikipedia-org-3485	704	22	and	and	CC
en-wikipedia-org-3485	704	23	suggests	suggest	VBZ
en-wikipedia-org-3485	704	24	methods	method	NNS
en-wikipedia-org-3485	704	25	to	to	TO
en-wikipedia-org-3485	704	26	analyze	analyze	VB
en-wikipedia-org-3485	704	27	their	-PRON-	PRP$
en-wikipedia-org-3485	704	28	efficacy	efficacy	NN
en-wikipedia-org-3485	704	29	(	(	-LRB-
en-wikipedia-org-3485	704	30	119	119	CD
en-wikipedia-org-3485	704	31	)	)	-RRB-
en-wikipedia-org-3485	704	32	.	.	.
en-wikipedia-org-3485	705	1	Over	over	IN
en-wikipedia-org-3485	705	2	the	the	DT
en-wikipedia-org-3485	705	3	past	past	JJ
en-wikipedia-org-3485	705	4	two	two	CD
en-wikipedia-org-3485	705	5	decades	decade	NNS
en-wikipedia-org-3485	705	6	,	,	,
en-wikipedia-org-3485	705	7	research	research	NN
en-wikipedia-org-3485	705	8	has	have	VBZ
en-wikipedia-org-3485	705	9	progressed	progress	VBN
en-wikipedia-org-3485	705	10	from	from	IN
en-wikipedia-org-3485	705	11	identifying	identify	VBG
en-wikipedia-org-3485	705	12	ΔFosB	ΔFosB	VBN
en-wikipedia-org-3485	705	13	induction	induction	NN
en-wikipedia-org-3485	705	14	to	to	IN
en-wikipedia-org-3485	705	15	investigating	investigate	VBG
en-wikipedia-org-3485	705	16	its	-PRON-	PRP$
en-wikipedia-org-3485	705	17	subsequent	subsequent	JJ
en-wikipedia-org-3485	705	18	action	action	NN
en-wikipedia-org-3485	705	19	(	(	-LRB-
en-wikipedia-org-3485	705	20	38	38	CD
en-wikipedia-org-3485	705	21	)	)	-RRB-
en-wikipedia-org-3485	705	22	.	.	.
en-wikipedia-org-3485	706	1	It	-PRON-	PRP
en-wikipedia-org-3485	706	2	is	be	VBZ
en-wikipedia-org-3485	706	3	likely	likely	JJ
en-wikipedia-org-3485	706	4	that	that	WDT
en-wikipedia-org-3485	706	5	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	706	6	research	research	NN
en-wikipedia-org-3485	706	7	will	will	MD
en-wikipedia-org-3485	706	8	now	now	RB
en-wikipedia-org-3485	706	9	progress	progress	VB
en-wikipedia-org-3485	706	10	into	into	IN
en-wikipedia-org-3485	706	11	a	a	DT
en-wikipedia-org-3485	706	12	new	new	JJ
en-wikipedia-org-3485	706	13	era	era	NN
en-wikipedia-org-3485	706	14	–	–	:
en-wikipedia-org-3485	706	15	the	the	DT
en-wikipedia-org-3485	706	16	use	use	NN
en-wikipedia-org-3485	706	17	of	of	IN
en-wikipedia-org-3485	706	18	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	706	19	as	as	IN
en-wikipedia-org-3485	706	20	a	a	DT
en-wikipedia-org-3485	706	21	biomarker	biomarker	NN
en-wikipedia-org-3485	706	22	.	.	.
en-wikipedia-org-3485	707	1	...	...	NFP
en-wikipedia-org-3485	708	1	Conclusions	conclusion	NNS
en-wikipedia-org-3485	708	2	ΔFosB	ΔFosB	VBZ
en-wikipedia-org-3485	708	3	is	be	VBZ
en-wikipedia-org-3485	708	4	an	an	DT
en-wikipedia-org-3485	708	5	essential	essential	JJ
en-wikipedia-org-3485	708	6	transcription	transcription	NN
en-wikipedia-org-3485	708	7	factor	factor	NN
en-wikipedia-org-3485	708	8	implicated	implicate	VBN
en-wikipedia-org-3485	708	9	in	in	IN
en-wikipedia-org-3485	708	10	the	the	DT
en-wikipedia-org-3485	708	11	molecular	molecular	JJ
en-wikipedia-org-3485	708	12	and	and	CC
en-wikipedia-org-3485	708	13	behavioral	behavioral	JJ
en-wikipedia-org-3485	708	14	pathways	pathway	NNS
en-wikipedia-org-3485	708	15	of	of	IN
en-wikipedia-org-3485	708	16	addiction	addiction	NN
en-wikipedia-org-3485	708	17	following	follow	VBG
en-wikipedia-org-3485	708	18	repeated	repeat	VBN
en-wikipedia-org-3485	708	19	drug	drug	NN
en-wikipedia-org-3485	708	20	exposure	exposure	NN
en-wikipedia-org-3485	708	21	.	.	.
en-wikipedia-org-3485	709	1	The	the	DT
en-wikipedia-org-3485	709	2	formation	formation	NN
en-wikipedia-org-3485	709	3	of	of	IN
en-wikipedia-org-3485	709	4	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	709	5	in	in	IN
en-wikipedia-org-3485	709	6	multiple	multiple	JJ
en-wikipedia-org-3485	709	7	brain	brain	NN
en-wikipedia-org-3485	709	8	regions	region	NNS
en-wikipedia-org-3485	709	9	,	,	,
en-wikipedia-org-3485	709	10	and	and	CC
en-wikipedia-org-3485	709	11	the	the	DT
en-wikipedia-org-3485	709	12	molecular	molecular	JJ
en-wikipedia-org-3485	709	13	pathway	pathway	NN
en-wikipedia-org-3485	709	14	leading	lead	VBG
en-wikipedia-org-3485	709	15	to	to	IN
en-wikipedia-org-3485	709	16	the	the	DT
en-wikipedia-org-3485	709	17	formation	formation	NN
en-wikipedia-org-3485	709	18	of	of	IN
en-wikipedia-org-3485	709	19	AP-1	ap-1	JJ
en-wikipedia-org-3485	709	20	complexes	complex	NNS
en-wikipedia-org-3485	709	21	is	be	VBZ
en-wikipedia-org-3485	709	22	well	well	RB
en-wikipedia-org-3485	709	23	understood	understand	VBN
en-wikipedia-org-3485	709	24	.	.	.
en-wikipedia-org-3485	710	1	The	the	DT
en-wikipedia-org-3485	710	2	establishment	establishment	NN
en-wikipedia-org-3485	710	3	of	of	IN
en-wikipedia-org-3485	710	4	a	a	DT
en-wikipedia-org-3485	710	5	functional	functional	JJ
en-wikipedia-org-3485	710	6	purpose	purpose	NN
en-wikipedia-org-3485	710	7	for	for	IN
en-wikipedia-org-3485	710	8	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	710	9	has	have	VBZ
en-wikipedia-org-3485	710	10	allowed	allow	VBN
en-wikipedia-org-3485	710	11	further	further	JJ
en-wikipedia-org-3485	710	12	determination	determination	NN
en-wikipedia-org-3485	710	13	as	as	IN
en-wikipedia-org-3485	710	14	to	to	IN
en-wikipedia-org-3485	710	15	some	some	DT
en-wikipedia-org-3485	710	16	of	of	IN
en-wikipedia-org-3485	710	17	the	the	DT
en-wikipedia-org-3485	710	18	key	key	JJ
en-wikipedia-org-3485	710	19	aspects	aspect	NNS
en-wikipedia-org-3485	710	20	of	of	IN
en-wikipedia-org-3485	710	21	its	-PRON-	PRP$
en-wikipedia-org-3485	710	22	molecular	molecular	JJ
en-wikipedia-org-3485	710	23	cascades	cascade	NNS
en-wikipedia-org-3485	710	24	,	,	,
en-wikipedia-org-3485	710	25	involving	involve	VBG
en-wikipedia-org-3485	710	26	effectors	effector	NNS
en-wikipedia-org-3485	710	27	such	such	JJ
en-wikipedia-org-3485	710	28	as	as	IN
en-wikipedia-org-3485	710	29	GluR2	GluR2	NNP
en-wikipedia-org-3485	710	30	(	(	-LRB-
en-wikipedia-org-3485	710	31	87,88	87,88	CD
en-wikipedia-org-3485	710	32	)	)	-RRB-
en-wikipedia-org-3485	710	33	,	,	,
en-wikipedia-org-3485	710	34	Cdk5	Cdk5	NNP
en-wikipedia-org-3485	710	35	(	(	-LRB-
en-wikipedia-org-3485	710	36	93	93	CD
en-wikipedia-org-3485	710	37	)	)	-RRB-
en-wikipedia-org-3485	710	38	and	and	CC
en-wikipedia-org-3485	710	39	NFkB	nfkb	ADD
en-wikipedia-org-3485	710	40	(	(	-LRB-
en-wikipedia-org-3485	710	41	100	100	CD
en-wikipedia-org-3485	710	42	)	)	-RRB-
en-wikipedia-org-3485	710	43	.	.	.
en-wikipedia-org-3485	711	1	Moreover	moreover	RB
en-wikipedia-org-3485	711	2	,	,	,
en-wikipedia-org-3485	711	3	many	many	JJ
en-wikipedia-org-3485	711	4	of	of	IN
en-wikipedia-org-3485	711	5	these	these	DT
en-wikipedia-org-3485	711	6	molecular	molecular	JJ
en-wikipedia-org-3485	711	7	changes	change	NNS
en-wikipedia-org-3485	711	8	identified	identify	VBN
en-wikipedia-org-3485	711	9	are	be	VBP
en-wikipedia-org-3485	711	10	now	now	RB
en-wikipedia-org-3485	711	11	directly	directly	RB
en-wikipedia-org-3485	711	12	linked	link	VBN
en-wikipedia-org-3485	711	13	to	to	IN
en-wikipedia-org-3485	711	14	the	the	DT
en-wikipedia-org-3485	711	15	structural	structural	JJ
en-wikipedia-org-3485	711	16	,	,	,
en-wikipedia-org-3485	711	17	physiological	physiological	JJ
en-wikipedia-org-3485	711	18	and	and	CC
en-wikipedia-org-3485	711	19	behavioral	behavioral	JJ
en-wikipedia-org-3485	711	20	changes	change	NNS
en-wikipedia-org-3485	711	21	observed	observe	VBD
en-wikipedia-org-3485	711	22	following	follow	VBG
en-wikipedia-org-3485	711	23	chronic	chronic	JJ
en-wikipedia-org-3485	711	24	drug	drug	NN
en-wikipedia-org-3485	711	25	exposure	exposure	NN
en-wikipedia-org-3485	711	26	(	(	-LRB-
en-wikipedia-org-3485	711	27	60,95,97,102	60,95,97,102	CD
en-wikipedia-org-3485	711	28	)	)	-RRB-
en-wikipedia-org-3485	711	29	.	.	.
en-wikipedia-org-3485	712	1	New	new	JJ
en-wikipedia-org-3485	712	2	frontiers	frontier	NNS
en-wikipedia-org-3485	712	3	of	of	IN
en-wikipedia-org-3485	712	4	research	research	NN
en-wikipedia-org-3485	712	5	investigating	investigate	VBG
en-wikipedia-org-3485	712	6	the	the	DT
en-wikipedia-org-3485	712	7	molecular	molecular	JJ
en-wikipedia-org-3485	712	8	roles	role	NNS
en-wikipedia-org-3485	712	9	of	of	IN
en-wikipedia-org-3485	712	10	ΔFosB	ΔFosB	:
en-wikipedia-org-3485	712	11	have	have	VBP
en-wikipedia-org-3485	712	12	been	be	VBN
en-wikipedia-org-3485	712	13	opened	open	VBN
en-wikipedia-org-3485	712	14	by	by	IN
en-wikipedia-org-3485	712	15	epigenetic	epigenetic	JJ
en-wikipedia-org-3485	712	16	studies	study	NNS
en-wikipedia-org-3485	712	17	,	,	,
en-wikipedia-org-3485	712	18	and	and	CC
en-wikipedia-org-3485	712	19	recent	recent	JJ
en-wikipedia-org-3485	712	20	advances	advance	NNS
en-wikipedia-org-3485	712	21	have	have	VBP
en-wikipedia-org-3485	712	22	illustrated	illustrate	VBN
en-wikipedia-org-3485	712	23	the	the	DT
en-wikipedia-org-3485	712	24	role	role	NN
en-wikipedia-org-3485	712	25	of	of	IN
en-wikipedia-org-3485	712	26	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	712	27	acting	act	VBG
en-wikipedia-org-3485	712	28	on	on	IN
en-wikipedia-org-3485	712	29	DNA	dna	NN
en-wikipedia-org-3485	712	30	and	and	CC
en-wikipedia-org-3485	712	31	histones	histone	NNS
en-wikipedia-org-3485	712	32	,	,	,
en-wikipedia-org-3485	712	33	truly	truly	RB
en-wikipedia-org-3485	712	34	as	as	IN
en-wikipedia-org-3485	712	35	a	a	DT
en-wikipedia-org-3485	712	36	molecular	molecular	JJ
en-wikipedia-org-3485	712	37	switch	switch	NN
en-wikipedia-org-3485	712	38	(	(	-LRB-
en-wikipedia-org-3485	712	39	34	34	CD
en-wikipedia-org-3485	712	40	)	)	-RRB-
en-wikipedia-org-3485	712	41	.	.	.
en-wikipedia-org-3485	713	1	As	as	IN
en-wikipedia-org-3485	713	2	a	a	DT
en-wikipedia-org-3485	713	3	consequence	consequence	NN
en-wikipedia-org-3485	713	4	of	of	IN
en-wikipedia-org-3485	713	5	our	-PRON-	PRP$
en-wikipedia-org-3485	713	6	improved	improved	JJ
en-wikipedia-org-3485	713	7	understanding	understanding	NN
en-wikipedia-org-3485	713	8	of	of	IN
en-wikipedia-org-3485	713	9	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	713	10	in	in	IN
en-wikipedia-org-3485	713	11	addiction	addiction	NN
en-wikipedia-org-3485	713	12	,	,	,
en-wikipedia-org-3485	713	13	it	-PRON-	PRP
en-wikipedia-org-3485	713	14	is	be	VBZ
en-wikipedia-org-3485	713	15	possible	possible	JJ
en-wikipedia-org-3485	713	16	to	to	TO
en-wikipedia-org-3485	713	17	evaluate	evaluate	VB
en-wikipedia-org-3485	713	18	the	the	DT
en-wikipedia-org-3485	713	19	addictive	addictive	JJ
en-wikipedia-org-3485	713	20	potential	potential	NN
en-wikipedia-org-3485	713	21	of	of	IN
en-wikipedia-org-3485	713	22	current	current	JJ
en-wikipedia-org-3485	713	23	medications	medication	NNS
en-wikipedia-org-3485	713	24	(	(	-LRB-
en-wikipedia-org-3485	713	25	119	119	CD
en-wikipedia-org-3485	713	26	)	)	-RRB-
en-wikipedia-org-3485	713	27	,	,	,
en-wikipedia-org-3485	713	28	as	as	RB
en-wikipedia-org-3485	713	29	well	well	RB
en-wikipedia-org-3485	713	30	as	as	IN
en-wikipedia-org-3485	713	31	use	use	VB
en-wikipedia-org-3485	713	32	it	-PRON-	PRP
en-wikipedia-org-3485	713	33	as	as	IN
en-wikipedia-org-3485	713	34	a	a	DT
en-wikipedia-org-3485	713	35	biomarker	biomarker	NN
en-wikipedia-org-3485	713	36	for	for	IN
en-wikipedia-org-3485	713	37	assessing	assess	VBG
en-wikipedia-org-3485	713	38	the	the	DT
en-wikipedia-org-3485	713	39	efficacy	efficacy	NN
en-wikipedia-org-3485	713	40	of	of	IN
en-wikipedia-org-3485	713	41	therapeutic	therapeutic	JJ
en-wikipedia-org-3485	713	42	interventions	intervention	NNS
en-wikipedia-org-3485	713	43	(	(	-LRB-
en-wikipedia-org-3485	713	44	121,122,124	121,122,124	CD
en-wikipedia-org-3485	713	45	)	)	-RRB-
en-wikipedia-org-3485	713	46	.	.	.
en-wikipedia-org-3485	714	1	Some	some	DT
en-wikipedia-org-3485	714	2	of	of	IN
en-wikipedia-org-3485	714	3	these	these	DT
en-wikipedia-org-3485	714	4	proposed	propose	VBN
en-wikipedia-org-3485	714	5	interventions	intervention	NNS
en-wikipedia-org-3485	714	6	have	have	VBP
en-wikipedia-org-3485	714	7	limitations	limitation	NNS
en-wikipedia-org-3485	714	8	(	(	-LRB-
en-wikipedia-org-3485	714	9	125	125	CD
en-wikipedia-org-3485	714	10	)	)	-RRB-
en-wikipedia-org-3485	714	11	or	or	CC
en-wikipedia-org-3485	714	12	are	be	VBP
en-wikipedia-org-3485	714	13	in	in	IN
en-wikipedia-org-3485	714	14	their	-PRON-	PRP$
en-wikipedia-org-3485	714	15	infancy	infancy	NN
en-wikipedia-org-3485	714	16	(	(	-LRB-
en-wikipedia-org-3485	714	17	75	75	CD
en-wikipedia-org-3485	714	18	)	)	-RRB-
en-wikipedia-org-3485	714	19	.	.	.
en-wikipedia-org-3485	715	1	However	however	RB
en-wikipedia-org-3485	715	2	,	,	,
en-wikipedia-org-3485	715	3	it	-PRON-	PRP
en-wikipedia-org-3485	715	4	is	be	VBZ
en-wikipedia-org-3485	715	5	hoped	hope	VBN
en-wikipedia-org-3485	715	6	that	that	IN
en-wikipedia-org-3485	715	7	some	some	DT
en-wikipedia-org-3485	715	8	of	of	IN
en-wikipedia-org-3485	715	9	these	these	DT
en-wikipedia-org-3485	715	10	preliminary	preliminary	JJ
en-wikipedia-org-3485	715	11	findings	finding	NNS
en-wikipedia-org-3485	715	12	may	may	MD
en-wikipedia-org-3485	715	13	lead	lead	VB
en-wikipedia-org-3485	715	14	to	to	IN
en-wikipedia-org-3485	715	15	innovative	innovative	JJ
en-wikipedia-org-3485	715	16	treatments	treatment	NNS
en-wikipedia-org-3485	715	17	,	,	,
en-wikipedia-org-3485	715	18	which	which	WDT
en-wikipedia-org-3485	715	19	are	be	VBP
en-wikipedia-org-3485	715	20	much	much	RB
en-wikipedia-org-3485	715	21	needed	need	VBN
en-wikipedia-org-3485	715	22	in	in	IN
en-wikipedia-org-3485	715	23	addiction	addiction	NN
en-wikipedia-org-3485	715	24	.	.	.
en-wikipedia-org-3485	716	1	^	^	NNP
en-wikipedia-org-3485	716	2	a	a	DT
en-wikipedia-org-3485	716	3	b	b	NN
en-wikipedia-org-3485	716	4	Olsen	Olsen	NNP
en-wikipedia-org-3485	716	5	CM	CM	NNP
en-wikipedia-org-3485	716	6	(	(	-LRB-
en-wikipedia-org-3485	716	7	December	December	NNP
en-wikipedia-org-3485	716	8	2011	2011	CD
en-wikipedia-org-3485	716	9	)	)	-RRB-
en-wikipedia-org-3485	716	10	.	.	.
en-wikipedia-org-3485	717	1	"	"	``
en-wikipedia-org-3485	717	2	Natural	natural	JJ
en-wikipedia-org-3485	717	3	rewards	reward	NNS
en-wikipedia-org-3485	717	4	,	,	,
en-wikipedia-org-3485	717	5	neuroplasticity	neuroplasticity	NN
en-wikipedia-org-3485	717	6	,	,	,
en-wikipedia-org-3485	717	7	and	and	CC
en-wikipedia-org-3485	717	8	non	non	JJ
en-wikipedia-org-3485	717	9	-	-	JJ
en-wikipedia-org-3485	717	10	drug	drug	JJ
en-wikipedia-org-3485	717	11	addictions	addiction	NNS
en-wikipedia-org-3485	717	12	"	"	''
en-wikipedia-org-3485	717	13	.	.	.
en-wikipedia-org-3485	718	1	Neuropharmacology	neuropharmacology	NN
en-wikipedia-org-3485	718	2	.	.	.
en-wikipedia-org-3485	719	1	61	61	CD
en-wikipedia-org-3485	719	2	(	(	-LRB-
en-wikipedia-org-3485	719	3	7	7	CD
en-wikipedia-org-3485	719	4	)	)	-RRB-
en-wikipedia-org-3485	719	5	:	:	:
en-wikipedia-org-3485	719	6	1109–1122	1109–1122	CD
en-wikipedia-org-3485	719	7	.	.	.
en-wikipedia-org-3485	720	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	720	2	/	/	SYM
en-wikipedia-org-3485	720	3	j.neuropharm.2011.03.010	j.neuropharm.2011.03.010	NNP
en-wikipedia-org-3485	720	4	.	.	.
en-wikipedia-org-3485	721	1	PMC	PMC	NNP
en-wikipedia-org-3485	721	2	 	  	_SP
en-wikipedia-org-3485	721	3	3139704	3139704	CD
en-wikipedia-org-3485	721	4	.	.	.
en-wikipedia-org-3485	722	1	PMID	PMID	NNP
en-wikipedia-org-3485	722	2	 	  	_SP
en-wikipedia-org-3485	722	3	21459101	21459101	CD
en-wikipedia-org-3485	722	4	.	.	.
en-wikipedia-org-3485	723	1	Functional	functional	JJ
en-wikipedia-org-3485	723	2	neuroimaging	neuroimaging	JJ
en-wikipedia-org-3485	723	3	studies	study	NNS
en-wikipedia-org-3485	723	4	in	in	IN
en-wikipedia-org-3485	723	5	humans	human	NNS
en-wikipedia-org-3485	723	6	have	have	VBP
en-wikipedia-org-3485	723	7	shown	show	VBN
en-wikipedia-org-3485	723	8	that	that	IN
en-wikipedia-org-3485	723	9	gambling	gambling	NN
en-wikipedia-org-3485	723	10	(	(	-LRB-
en-wikipedia-org-3485	723	11	Breiter	Breiter	NNP
en-wikipedia-org-3485	723	12	et	et	FW
en-wikipedia-org-3485	723	13	al	al	NNP
en-wikipedia-org-3485	723	14	,	,	,
en-wikipedia-org-3485	723	15	2001	2001	CD
en-wikipedia-org-3485	723	16	)	)	-RRB-
en-wikipedia-org-3485	723	17	,	,	,
en-wikipedia-org-3485	723	18	shopping	shop	VBG
en-wikipedia-org-3485	723	19	(	(	-LRB-
en-wikipedia-org-3485	723	20	Knutson	Knutson	NNP
en-wikipedia-org-3485	723	21	et	et	FW
en-wikipedia-org-3485	723	22	al	al	NNP
en-wikipedia-org-3485	723	23	,	,	,
en-wikipedia-org-3485	723	24	2007	2007	CD
en-wikipedia-org-3485	723	25	)	)	-RRB-
en-wikipedia-org-3485	723	26	,	,	,
en-wikipedia-org-3485	723	27	orgasm	orgasm	NNP
en-wikipedia-org-3485	723	28	(	(	-LRB-
en-wikipedia-org-3485	723	29	Komisaruk	Komisaruk	NNP
en-wikipedia-org-3485	723	30	et	et	FW
en-wikipedia-org-3485	723	31	al	al	NNP
en-wikipedia-org-3485	723	32	,	,	,
en-wikipedia-org-3485	723	33	2004	2004	CD
en-wikipedia-org-3485	723	34	)	)	-RRB-
en-wikipedia-org-3485	723	35	,	,	,
en-wikipedia-org-3485	723	36	playing	play	VBG
en-wikipedia-org-3485	723	37	video	video	NN
en-wikipedia-org-3485	723	38	games	game	NNS
en-wikipedia-org-3485	723	39	(	(	-LRB-
en-wikipedia-org-3485	723	40	Koepp	Koepp	NNP
en-wikipedia-org-3485	723	41	et	et	NNP
en-wikipedia-org-3485	723	42	al	al	NNP
en-wikipedia-org-3485	723	43	,	,	,
en-wikipedia-org-3485	723	44	1998	1998	CD
en-wikipedia-org-3485	723	45	;	;	:
en-wikipedia-org-3485	723	46	Hoeft	Hoeft	NNP
en-wikipedia-org-3485	723	47	et	et	NNP
en-wikipedia-org-3485	723	48	al	al	NNP
en-wikipedia-org-3485	723	49	,	,	,
en-wikipedia-org-3485	723	50	2008	2008	CD
en-wikipedia-org-3485	723	51	)	)	-RRB-
en-wikipedia-org-3485	723	52	and	and	CC
en-wikipedia-org-3485	723	53	the	the	DT
en-wikipedia-org-3485	723	54	sight	sight	NN
en-wikipedia-org-3485	723	55	of	of	IN
en-wikipedia-org-3485	723	56	appetizing	appetize	VBG
en-wikipedia-org-3485	723	57	food	food	NN
en-wikipedia-org-3485	723	58	(	(	-LRB-
en-wikipedia-org-3485	723	59	Wang	Wang	NNP
en-wikipedia-org-3485	723	60	et	et	NNP
en-wikipedia-org-3485	723	61	al	al	NNP
en-wikipedia-org-3485	723	62	,	,	,
en-wikipedia-org-3485	723	63	2004a	2004a	CD
en-wikipedia-org-3485	723	64	)	)	-RRB-
en-wikipedia-org-3485	723	65	activate	activate	VBP
en-wikipedia-org-3485	723	66	many	many	JJ
en-wikipedia-org-3485	723	67	of	of	IN
en-wikipedia-org-3485	723	68	the	the	DT
en-wikipedia-org-3485	723	69	same	same	JJ
en-wikipedia-org-3485	723	70	brain	brain	NN
en-wikipedia-org-3485	723	71	regions	region	NNS
en-wikipedia-org-3485	723	72	(	(	-LRB-
en-wikipedia-org-3485	723	73	i.e.	i.e.	FW
en-wikipedia-org-3485	723	74	,	,	,
en-wikipedia-org-3485	723	75	the	the	DT
en-wikipedia-org-3485	723	76	mesocorticolimbic	mesocorticolimbic	JJ
en-wikipedia-org-3485	723	77	system	system	NN
en-wikipedia-org-3485	723	78	and	and	CC
en-wikipedia-org-3485	723	79	extended	extend	VBD
en-wikipedia-org-3485	723	80	amygdala	amygdala	NNP
en-wikipedia-org-3485	723	81	)	)	-RRB-
en-wikipedia-org-3485	723	82	as	as	IN
en-wikipedia-org-3485	723	83	drugs	drug	NNS
en-wikipedia-org-3485	723	84	of	of	IN
en-wikipedia-org-3485	723	85	abuse	abuse	NN
en-wikipedia-org-3485	723	86	(	(	-LRB-
en-wikipedia-org-3485	723	87	Volkow	Volkow	NNP
en-wikipedia-org-3485	723	88	et	et	NNP
en-wikipedia-org-3485	723	89	al	al	NNP
en-wikipedia-org-3485	723	90	,	,	,
en-wikipedia-org-3485	723	91	2004	2004	CD
en-wikipedia-org-3485	723	92	)	)	-RRB-
en-wikipedia-org-3485	723	93	.	.	.
en-wikipedia-org-3485	724	1	...	...	:
en-wikipedia-org-3485	724	2	Cross	cross	JJ
en-wikipedia-org-3485	724	3	-	-	NN
en-wikipedia-org-3485	724	4	sensitization	sensitization	NN
en-wikipedia-org-3485	724	5	is	be	VBZ
en-wikipedia-org-3485	724	6	also	also	RB
en-wikipedia-org-3485	724	7	bidirectional	bidirectional	JJ
en-wikipedia-org-3485	724	8	,	,	,
en-wikipedia-org-3485	724	9	as	as	IN
en-wikipedia-org-3485	724	10	a	a	DT
en-wikipedia-org-3485	724	11	history	history	NN
en-wikipedia-org-3485	724	12	of	of	IN
en-wikipedia-org-3485	724	13	amphetamine	amphetamine	NNP
en-wikipedia-org-3485	724	14	administration	administration	NNP
en-wikipedia-org-3485	724	15	facilitates	facilitate	VBZ
en-wikipedia-org-3485	724	16	sexual	sexual	JJ
en-wikipedia-org-3485	724	17	behavior	behavior	NN
en-wikipedia-org-3485	724	18	and	and	CC
en-wikipedia-org-3485	724	19	enhances	enhance	VBZ
en-wikipedia-org-3485	724	20	the	the	DT
en-wikipedia-org-3485	724	21	associated	associated	JJ
en-wikipedia-org-3485	724	22	increase	increase	NN
en-wikipedia-org-3485	724	23	in	in	IN
en-wikipedia-org-3485	724	24	NAc	NAc	NNP
en-wikipedia-org-3485	724	25	DA	DA	NNP
en-wikipedia-org-3485	724	26	 	  	_SP
en-wikipedia-org-3485	724	27	...	...	.
en-wikipedia-org-3485	724	28	As	as	IN
en-wikipedia-org-3485	724	29	described	describe	VBN
en-wikipedia-org-3485	724	30	for	for	IN
en-wikipedia-org-3485	724	31	food	food	NN
en-wikipedia-org-3485	724	32	reward	reward	NN
en-wikipedia-org-3485	724	33	,	,	,
en-wikipedia-org-3485	724	34	sexual	sexual	JJ
en-wikipedia-org-3485	724	35	experience	experience	NN
en-wikipedia-org-3485	724	36	can	can	MD
en-wikipedia-org-3485	724	37	also	also	RB
en-wikipedia-org-3485	724	38	lead	lead	VB
en-wikipedia-org-3485	724	39	to	to	IN
en-wikipedia-org-3485	724	40	activation	activation	NN
en-wikipedia-org-3485	724	41	of	of	IN
en-wikipedia-org-3485	724	42	plasticity	plasticity	NN
en-wikipedia-org-3485	724	43	-	-	HYPH
en-wikipedia-org-3485	724	44	related	relate	VBN
en-wikipedia-org-3485	724	45	signaling	signaling	NN
en-wikipedia-org-3485	724	46	cascades	cascade	VBZ
en-wikipedia-org-3485	724	47	.	.	.
en-wikipedia-org-3485	725	1	The	the	DT
en-wikipedia-org-3485	725	2	transcription	transcription	NN
en-wikipedia-org-3485	725	3	factor	factor	NN
en-wikipedia-org-3485	725	4	delta	delta	NN
en-wikipedia-org-3485	725	5	FosB	FosB	NNP
en-wikipedia-org-3485	725	6	is	be	VBZ
en-wikipedia-org-3485	725	7	increased	increase	VBN
en-wikipedia-org-3485	725	8	in	in	IN
en-wikipedia-org-3485	725	9	the	the	DT
en-wikipedia-org-3485	725	10	NAc	NAc	NNS
en-wikipedia-org-3485	725	11	,	,	,
en-wikipedia-org-3485	725	12	PFC	PFC	NNP
en-wikipedia-org-3485	725	13	,	,	,
en-wikipedia-org-3485	725	14	dorsal	dorsal	NN
en-wikipedia-org-3485	725	15	striatum	striatum	NN
en-wikipedia-org-3485	725	16	,	,	,
en-wikipedia-org-3485	725	17	and	and	CC
en-wikipedia-org-3485	725	18	VTA	VTA	NNP
en-wikipedia-org-3485	725	19	following	follow	VBG
en-wikipedia-org-3485	725	20	repeated	repeat	VBN
en-wikipedia-org-3485	725	21	sexual	sexual	JJ
en-wikipedia-org-3485	725	22	behavior	behavior	NN
en-wikipedia-org-3485	725	23	(	(	-LRB-
en-wikipedia-org-3485	725	24	Wallace	Wallace	NNP
en-wikipedia-org-3485	725	25	et	et	FW
en-wikipedia-org-3485	725	26	al	al	NNP
en-wikipedia-org-3485	725	27	.	.	NNP
en-wikipedia-org-3485	725	28	,	,	,
en-wikipedia-org-3485	725	29	2008	2008	CD
en-wikipedia-org-3485	725	30	;	;	:
en-wikipedia-org-3485	725	31	Pitchers	Pitchers	NNP
en-wikipedia-org-3485	725	32	et	et	NNP
en-wikipedia-org-3485	725	33	al	al	NNP
en-wikipedia-org-3485	725	34	.	.	NNP
en-wikipedia-org-3485	725	35	,	,	,
en-wikipedia-org-3485	725	36	2010b	2010b	CD
en-wikipedia-org-3485	725	37	)	)	-RRB-
en-wikipedia-org-3485	725	38	.	.	.
en-wikipedia-org-3485	726	1	This	this	DT
en-wikipedia-org-3485	726	2	natural	natural	JJ
en-wikipedia-org-3485	726	3	increase	increase	NN
en-wikipedia-org-3485	726	4	in	in	IN
en-wikipedia-org-3485	726	5	delta	delta	NN
en-wikipedia-org-3485	726	6	FosB	FosB	NNP
en-wikipedia-org-3485	726	7	or	or	CC
en-wikipedia-org-3485	726	8	viral	viral	JJ
en-wikipedia-org-3485	726	9	overexpression	overexpression	NN
en-wikipedia-org-3485	726	10	of	of	IN
en-wikipedia-org-3485	726	11	delta	delta	NN
en-wikipedia-org-3485	726	12	FosB	FosB	NNP
en-wikipedia-org-3485	726	13	within	within	IN
en-wikipedia-org-3485	726	14	the	the	DT
en-wikipedia-org-3485	726	15	NAc	NAc	NNS
en-wikipedia-org-3485	726	16	modulates	modulate	VBZ
en-wikipedia-org-3485	726	17	sexual	sexual	JJ
en-wikipedia-org-3485	726	18	performance	performance	NN
en-wikipedia-org-3485	726	19	,	,	,
en-wikipedia-org-3485	726	20	and	and	CC
en-wikipedia-org-3485	726	21	NAc	NAc	NNP
en-wikipedia-org-3485	726	22	blockade	blockade	NN
en-wikipedia-org-3485	726	23	of	of	IN
en-wikipedia-org-3485	726	24	delta	delta	NN
en-wikipedia-org-3485	726	25	FosB	FosB	NNP
en-wikipedia-org-3485	726	26	attenuates	attenuate	VBZ
en-wikipedia-org-3485	726	27	this	this	DT
en-wikipedia-org-3485	726	28	behavior	behavior	NN
en-wikipedia-org-3485	726	29	(	(	-LRB-
en-wikipedia-org-3485	726	30	Hedges	Hedges	NNP
en-wikipedia-org-3485	726	31	et	et	NNP
en-wikipedia-org-3485	726	32	al	al	NNP
en-wikipedia-org-3485	726	33	,	,	,
en-wikipedia-org-3485	726	34	2009	2009	CD
en-wikipedia-org-3485	726	35	;	;	:
en-wikipedia-org-3485	726	36	Pitchers	Pitchers	NNP
en-wikipedia-org-3485	726	37	et	et	NNP
en-wikipedia-org-3485	726	38	al	al	NNP
en-wikipedia-org-3485	726	39	.	.	NNP
en-wikipedia-org-3485	726	40	,	,	,
en-wikipedia-org-3485	726	41	2010b	2010b	CD
en-wikipedia-org-3485	726	42	)	)	-RRB-
en-wikipedia-org-3485	726	43	.	.	.
en-wikipedia-org-3485	727	1	Further	further	RB
en-wikipedia-org-3485	727	2	,	,	,
en-wikipedia-org-3485	727	3	viral	viral	JJ
en-wikipedia-org-3485	727	4	overexpression	overexpression	NN
en-wikipedia-org-3485	727	5	of	of	IN
en-wikipedia-org-3485	727	6	delta	delta	NN
en-wikipedia-org-3485	727	7	FosB	FosB	NNP
en-wikipedia-org-3485	727	8	enhances	enhance	VBZ
en-wikipedia-org-3485	727	9	the	the	DT
en-wikipedia-org-3485	727	10	conditioned	condition	VBN
en-wikipedia-org-3485	727	11	place	place	NN
en-wikipedia-org-3485	727	12	preference	preference	NN
en-wikipedia-org-3485	727	13	for	for	IN
en-wikipedia-org-3485	727	14	an	an	DT
en-wikipedia-org-3485	727	15	environment	environment	NN
en-wikipedia-org-3485	727	16	paired	pair	VBN
en-wikipedia-org-3485	727	17	with	with	IN
en-wikipedia-org-3485	727	18	sexual	sexual	JJ
en-wikipedia-org-3485	727	19	experience	experience	NN
en-wikipedia-org-3485	727	20	(	(	-LRB-
en-wikipedia-org-3485	727	21	Hedges	Hedges	NNP
en-wikipedia-org-3485	727	22	et	et	NNP
en-wikipedia-org-3485	727	23	al	al	NNP
en-wikipedia-org-3485	727	24	.	.	NNP
en-wikipedia-org-3485	727	25	,	,	,
en-wikipedia-org-3485	727	26	2009	2009	CD
en-wikipedia-org-3485	727	27	)	)	-RRB-
en-wikipedia-org-3485	727	28	.	.	.
en-wikipedia-org-3485	728	1	...	...	NFP
en-wikipedia-org-3485	729	1	In	in	IN
en-wikipedia-org-3485	729	2	some	some	DT
en-wikipedia-org-3485	729	3	people	people	NNS
en-wikipedia-org-3485	729	4	,	,	,
en-wikipedia-org-3485	729	5	there	there	EX
en-wikipedia-org-3485	729	6	is	be	VBZ
en-wikipedia-org-3485	729	7	a	a	DT
en-wikipedia-org-3485	729	8	transition	transition	NN
en-wikipedia-org-3485	729	9	from	from	IN
en-wikipedia-org-3485	729	10	"	"	``
en-wikipedia-org-3485	729	11	normal	normal	JJ
en-wikipedia-org-3485	729	12	"	"	''
en-wikipedia-org-3485	729	13	to	to	IN
en-wikipedia-org-3485	729	14	compulsive	compulsive	JJ
en-wikipedia-org-3485	729	15	engagement	engagement	NN
en-wikipedia-org-3485	729	16	in	in	IN
en-wikipedia-org-3485	729	17	natural	natural	JJ
en-wikipedia-org-3485	729	18	rewards	reward	NNS
en-wikipedia-org-3485	729	19	(	(	-LRB-
en-wikipedia-org-3485	729	20	such	such	JJ
en-wikipedia-org-3485	729	21	as	as	IN
en-wikipedia-org-3485	729	22	food	food	NN
en-wikipedia-org-3485	729	23	or	or	CC
en-wikipedia-org-3485	729	24	sex	sex	NN
en-wikipedia-org-3485	729	25	)	)	-RRB-
en-wikipedia-org-3485	729	26	,	,	,
en-wikipedia-org-3485	729	27	a	a	DT
en-wikipedia-org-3485	729	28	condition	condition	NN
en-wikipedia-org-3485	729	29	that	that	IN
en-wikipedia-org-3485	729	30	some	some	DT
en-wikipedia-org-3485	729	31	have	have	VBP
en-wikipedia-org-3485	729	32	termed	term	VBN
en-wikipedia-org-3485	729	33	behavioral	behavioral	JJ
en-wikipedia-org-3485	729	34	or	or	CC
en-wikipedia-org-3485	729	35	non	non	JJ
en-wikipedia-org-3485	729	36	-	-	JJ
en-wikipedia-org-3485	729	37	drug	drug	JJ
en-wikipedia-org-3485	729	38	addictions	addiction	NNS
en-wikipedia-org-3485	729	39	(	(	-LRB-
en-wikipedia-org-3485	729	40	Holden	Holden	NNP
en-wikipedia-org-3485	729	41	,	,	,
en-wikipedia-org-3485	729	42	2001	2001	CD
en-wikipedia-org-3485	729	43	;	;	:
en-wikipedia-org-3485	729	44	Grant	Grant	NNP
en-wikipedia-org-3485	729	45	et	et	NNP
en-wikipedia-org-3485	729	46	al	al	NNP
en-wikipedia-org-3485	729	47	.	.	NNP
en-wikipedia-org-3485	729	48	,	,	,
en-wikipedia-org-3485	729	49	2006a	2006a	CD
en-wikipedia-org-3485	729	50	)	)	-RRB-
en-wikipedia-org-3485	729	51	.	.	.
en-wikipedia-org-3485	730	1	...	...	NFP
en-wikipedia-org-3485	731	1	In	in	IN
en-wikipedia-org-3485	731	2	humans	human	NNS
en-wikipedia-org-3485	731	3	,	,	,
en-wikipedia-org-3485	731	4	the	the	DT
en-wikipedia-org-3485	731	5	role	role	NN
en-wikipedia-org-3485	731	6	of	of	IN
en-wikipedia-org-3485	731	7	dopamine	dopamine	NN
en-wikipedia-org-3485	731	8	signaling	signaling	NN
en-wikipedia-org-3485	731	9	in	in	IN
en-wikipedia-org-3485	731	10	incentive	incentive	NN
en-wikipedia-org-3485	731	11	-	-	HYPH
en-wikipedia-org-3485	731	12	sensitization	sensitization	NN
en-wikipedia-org-3485	731	13	processes	process	NNS
en-wikipedia-org-3485	731	14	has	have	VBZ
en-wikipedia-org-3485	731	15	recently	recently	RB
en-wikipedia-org-3485	731	16	been	be	VBN
en-wikipedia-org-3485	731	17	highlighted	highlight	VBN
en-wikipedia-org-3485	731	18	by	by	IN
en-wikipedia-org-3485	731	19	the	the	DT
en-wikipedia-org-3485	731	20	observation	observation	NN
en-wikipedia-org-3485	731	21	of	of	IN
en-wikipedia-org-3485	731	22	a	a	DT
en-wikipedia-org-3485	731	23	dopamine	dopamine	NN
en-wikipedia-org-3485	731	24	dysregulation	dysregulation	NN
en-wikipedia-org-3485	731	25	syndrome	syndrome	NN
en-wikipedia-org-3485	731	26	in	in	IN
en-wikipedia-org-3485	731	27	some	some	DT
en-wikipedia-org-3485	731	28	patients	patient	NNS
en-wikipedia-org-3485	731	29	taking	take	VBG
en-wikipedia-org-3485	731	30	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	731	31	drugs	drug	NNS
en-wikipedia-org-3485	731	32	.	.	.
en-wikipedia-org-3485	732	1	This	this	DT
en-wikipedia-org-3485	732	2	syndrome	syndrome	NN
en-wikipedia-org-3485	732	3	is	be	VBZ
en-wikipedia-org-3485	732	4	characterized	characterize	VBN
en-wikipedia-org-3485	732	5	by	by	IN
en-wikipedia-org-3485	732	6	a	a	DT
en-wikipedia-org-3485	732	7	medication	medication	NN
en-wikipedia-org-3485	732	8	-	-	HYPH
en-wikipedia-org-3485	732	9	induced	induce	VBN
en-wikipedia-org-3485	732	10	increase	increase	NN
en-wikipedia-org-3485	732	11	in	in	IN
en-wikipedia-org-3485	732	12	(	(	-LRB-
en-wikipedia-org-3485	732	13	or	or	CC
en-wikipedia-org-3485	732	14	compulsive	compulsive	JJ
en-wikipedia-org-3485	732	15	)	)	-RRB-
en-wikipedia-org-3485	732	16	engagement	engagement	NN
en-wikipedia-org-3485	732	17	in	in	IN
en-wikipedia-org-3485	732	18	non	non	JJ
en-wikipedia-org-3485	732	19	-	-	JJ
en-wikipedia-org-3485	732	20	drug	drug	JJ
en-wikipedia-org-3485	732	21	rewards	reward	NNS
en-wikipedia-org-3485	732	22	such	such	JJ
en-wikipedia-org-3485	732	23	as	as	IN
en-wikipedia-org-3485	732	24	gambling	gambling	NN
en-wikipedia-org-3485	732	25	,	,	,
en-wikipedia-org-3485	732	26	shopping	shopping	NN
en-wikipedia-org-3485	732	27	,	,	,
en-wikipedia-org-3485	732	28	or	or	CC
en-wikipedia-org-3485	732	29	sex	sex	NN
en-wikipedia-org-3485	732	30	(	(	-LRB-
en-wikipedia-org-3485	732	31	Evans	Evans	NNP
en-wikipedia-org-3485	732	32	et	et	NNP
en-wikipedia-org-3485	732	33	al	al	NNP
en-wikipedia-org-3485	732	34	,	,	,
en-wikipedia-org-3485	732	35	2006	2006	CD
en-wikipedia-org-3485	732	36	;	;	:
en-wikipedia-org-3485	732	37	Aiken	Aiken	NNP
en-wikipedia-org-3485	732	38	,	,	,
en-wikipedia-org-3485	732	39	2007	2007	CD
en-wikipedia-org-3485	732	40	;	;	:
en-wikipedia-org-3485	732	41	Lader	Lader	NNP
en-wikipedia-org-3485	732	42	,	,	,
en-wikipedia-org-3485	732	43	2008	2008	CD
en-wikipedia-org-3485	732	44	)	)	-RRB-
en-wikipedia-org-3485	732	45	.	.	.
en-wikipedia-org-3485	732	46	"	"	''
en-wikipedia-org-3485	733	1	Table	table	NN
en-wikipedia-org-3485	733	2	1	1	CD
en-wikipedia-org-3485	733	3	:	:	:
en-wikipedia-org-3485	733	4	Summary	summary	NN
en-wikipedia-org-3485	733	5	of	of	IN
en-wikipedia-org-3485	733	6	plasticity	plasticity	NN
en-wikipedia-org-3485	733	7	observed	observe	VBD
en-wikipedia-org-3485	733	8	following	follow	VBG
en-wikipedia-org-3485	733	9	exposure	exposure	NN
en-wikipedia-org-3485	733	10	to	to	IN
en-wikipedia-org-3485	733	11	drug	drug	NN
en-wikipedia-org-3485	733	12	or	or	CC
en-wikipedia-org-3485	733	13	natural	natural	JJ
en-wikipedia-org-3485	733	14	reinforcers	reinforcer	NNS
en-wikipedia-org-3485	733	15	"	"	''
en-wikipedia-org-3485	733	16	^	^	FW
en-wikipedia-org-3485	733	17	a	a	DT
en-wikipedia-org-3485	733	18	b	b	NN
en-wikipedia-org-3485	733	19	Biliński	Biliński	NNP
en-wikipedia-org-3485	733	20	P	P	NNP
en-wikipedia-org-3485	733	21	,	,	,
en-wikipedia-org-3485	733	22	Wojtyła	Wojtyła	NNP
en-wikipedia-org-3485	733	23	A	A	NNP
en-wikipedia-org-3485	733	24	,	,	,
en-wikipedia-org-3485	733	25	Kapka	Kapka	NNP
en-wikipedia-org-3485	733	26	-	-	HYPH
en-wikipedia-org-3485	733	27	Skrzypczak	Skrzypczak	NNP
en-wikipedia-org-3485	733	28	L	L	NNP
en-wikipedia-org-3485	733	29	,	,	,
en-wikipedia-org-3485	733	30	Chwedorowicz	Chwedorowicz	NNP
en-wikipedia-org-3485	733	31	R	R	NNP
en-wikipedia-org-3485	733	32	,	,	,
en-wikipedia-org-3485	733	33	Cyranka	Cyranka	NNP
en-wikipedia-org-3485	733	34	M	M	NNP
en-wikipedia-org-3485	733	35	,	,	,
en-wikipedia-org-3485	733	36	Studziński	Studziński	NNP
en-wikipedia-org-3485	733	37	T	T	NNP
en-wikipedia-org-3485	733	38	(	(	-LRB-
en-wikipedia-org-3485	733	39	2012	2012	CD
en-wikipedia-org-3485	733	40	)	)	-RRB-
en-wikipedia-org-3485	733	41	.	.	.
en-wikipedia-org-3485	734	1	"	"	``
en-wikipedia-org-3485	734	2	Epigenetic	epigenetic	JJ
en-wikipedia-org-3485	734	3	regulation	regulation	NN
en-wikipedia-org-3485	734	4	in	in	IN
en-wikipedia-org-3485	734	5	drug	drug	NN
en-wikipedia-org-3485	734	6	addiction	addiction	NN
en-wikipedia-org-3485	734	7	"	"	''
en-wikipedia-org-3485	734	8	.	.	.
en-wikipedia-org-3485	735	1	Ann	Ann	NNP
en-wikipedia-org-3485	735	2	.	.	.
en-wikipedia-org-3485	736	1	Agric	agric	NN
en-wikipedia-org-3485	736	2	.	.	.
en-wikipedia-org-3485	737	1	Environ	Environ	NNP
en-wikipedia-org-3485	737	2	.	.	.
en-wikipedia-org-3485	738	1	Med	Med	NNP
en-wikipedia-org-3485	738	2	.	.	.
en-wikipedia-org-3485	739	1	19	19	CD
en-wikipedia-org-3485	739	2	(	(	-LRB-
en-wikipedia-org-3485	739	3	3	3	CD
en-wikipedia-org-3485	739	4	)	)	-RRB-
en-wikipedia-org-3485	739	5	:	:	:
en-wikipedia-org-3485	739	6	491–496	491–496	CD
en-wikipedia-org-3485	739	7	.	.	.
en-wikipedia-org-3485	740	1	PMID	PMID	NNP
en-wikipedia-org-3485	740	2	 	  	_SP
en-wikipedia-org-3485	740	3	23020045	23020045	CD
en-wikipedia-org-3485	740	4	.	.	.
en-wikipedia-org-3485	741	1	For	for	IN
en-wikipedia-org-3485	741	2	these	these	DT
en-wikipedia-org-3485	741	3	reasons	reason	NNS
en-wikipedia-org-3485	741	4	,	,	,
en-wikipedia-org-3485	741	5	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	741	6	is	be	VBZ
en-wikipedia-org-3485	741	7	considered	consider	VBN
en-wikipedia-org-3485	741	8	a	a	DT
en-wikipedia-org-3485	741	9	primary	primary	JJ
en-wikipedia-org-3485	741	10	and	and	CC
en-wikipedia-org-3485	741	11	causative	causative	JJ
en-wikipedia-org-3485	741	12	transcription	transcription	NN
en-wikipedia-org-3485	741	13	factor	factor	NN
en-wikipedia-org-3485	741	14	in	in	IN
en-wikipedia-org-3485	741	15	creating	create	VBG
en-wikipedia-org-3485	741	16	new	new	JJ
en-wikipedia-org-3485	741	17	neural	neural	JJ
en-wikipedia-org-3485	741	18	connections	connection	NNS
en-wikipedia-org-3485	741	19	in	in	IN
en-wikipedia-org-3485	741	20	the	the	DT
en-wikipedia-org-3485	741	21	reward	reward	NN
en-wikipedia-org-3485	741	22	centre	centre	NNP
en-wikipedia-org-3485	741	23	,	,	,
en-wikipedia-org-3485	741	24	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	741	25	cortex	cortex	NNP
en-wikipedia-org-3485	741	26	,	,	,
en-wikipedia-org-3485	741	27	and	and	CC
en-wikipedia-org-3485	741	28	other	other	JJ
en-wikipedia-org-3485	741	29	regions	region	NNS
en-wikipedia-org-3485	741	30	of	of	IN
en-wikipedia-org-3485	741	31	the	the	DT
en-wikipedia-org-3485	741	32	limbic	limbic	JJ
en-wikipedia-org-3485	741	33	system	system	NN
en-wikipedia-org-3485	741	34	.	.	.
en-wikipedia-org-3485	742	1	This	this	DT
en-wikipedia-org-3485	742	2	is	be	VBZ
en-wikipedia-org-3485	742	3	reflected	reflect	VBN
en-wikipedia-org-3485	742	4	in	in	IN
en-wikipedia-org-3485	742	5	the	the	DT
en-wikipedia-org-3485	742	6	increased	increased	JJ
en-wikipedia-org-3485	742	7	,	,	,
en-wikipedia-org-3485	742	8	stable	stable	JJ
en-wikipedia-org-3485	742	9	and	and	CC
en-wikipedia-org-3485	742	10	long	long	RB
en-wikipedia-org-3485	742	11	-	-	HYPH
en-wikipedia-org-3485	742	12	lasting	last	VBG
en-wikipedia-org-3485	742	13	level	level	NN
en-wikipedia-org-3485	742	14	of	of	IN
en-wikipedia-org-3485	742	15	sensitivity	sensitivity	NN
en-wikipedia-org-3485	742	16	to	to	IN
en-wikipedia-org-3485	742	17	cocaine	cocaine	NN
en-wikipedia-org-3485	742	18	and	and	CC
en-wikipedia-org-3485	742	19	other	other	JJ
en-wikipedia-org-3485	742	20	drugs	drug	NNS
en-wikipedia-org-3485	742	21	,	,	,
en-wikipedia-org-3485	742	22	and	and	CC
en-wikipedia-org-3485	742	23	tendency	tendency	NN
en-wikipedia-org-3485	742	24	to	to	TO
en-wikipedia-org-3485	742	25	relapse	relapse	VB
en-wikipedia-org-3485	742	26	even	even	RB
en-wikipedia-org-3485	742	27	after	after	IN
en-wikipedia-org-3485	742	28	long	long	JJ
en-wikipedia-org-3485	742	29	periods	period	NNS
en-wikipedia-org-3485	742	30	of	of	IN
en-wikipedia-org-3485	742	31	abstinence	abstinence	NN
en-wikipedia-org-3485	742	32	.	.	.
en-wikipedia-org-3485	743	1	These	these	DT
en-wikipedia-org-3485	743	2	newly	newly	RB
en-wikipedia-org-3485	743	3	constructed	construct	VBN
en-wikipedia-org-3485	743	4	networks	network	NNS
en-wikipedia-org-3485	743	5	function	function	VBP
en-wikipedia-org-3485	743	6	very	very	RB
en-wikipedia-org-3485	743	7	efficiently	efficiently	RB
en-wikipedia-org-3485	743	8	via	via	IN
en-wikipedia-org-3485	743	9	new	new	JJ
en-wikipedia-org-3485	743	10	pathways	pathway	NNS
en-wikipedia-org-3485	743	11	as	as	RB
en-wikipedia-org-3485	743	12	soon	soon	RB
en-wikipedia-org-3485	743	13	as	as	IN
en-wikipedia-org-3485	743	14	drugs	drug	NNS
en-wikipedia-org-3485	743	15	of	of	IN
en-wikipedia-org-3485	743	16	abuse	abuse	NN
en-wikipedia-org-3485	743	17	are	be	VBP
en-wikipedia-org-3485	743	18	further	further	RB
en-wikipedia-org-3485	743	19	taken	take	VBN
en-wikipedia-org-3485	743	20	 	  	_SP
en-wikipedia-org-3485	743	21	...	...	.
en-wikipedia-org-3485	744	1	In	in	IN
en-wikipedia-org-3485	744	2	this	this	DT
en-wikipedia-org-3485	744	3	way	way	NN
en-wikipedia-org-3485	744	4	,	,	,
en-wikipedia-org-3485	744	5	the	the	DT
en-wikipedia-org-3485	744	6	induction	induction	NN
en-wikipedia-org-3485	744	7	of	of	IN
en-wikipedia-org-3485	744	8	CDK5	CDK5	NNP
en-wikipedia-org-3485	744	9	gene	gene	NN
en-wikipedia-org-3485	744	10	expression	expression	NN
en-wikipedia-org-3485	744	11	occurs	occur	VBZ
en-wikipedia-org-3485	744	12	together	together	RB
en-wikipedia-org-3485	744	13	with	with	IN
en-wikipedia-org-3485	744	14	suppression	suppression	NN
en-wikipedia-org-3485	744	15	of	of	IN
en-wikipedia-org-3485	744	16	the	the	DT
en-wikipedia-org-3485	744	17	G9A	G9A	NNP
en-wikipedia-org-3485	744	18	gene	gene	NN
en-wikipedia-org-3485	744	19	coding	code	VBG
en-wikipedia-org-3485	744	20	for	for	IN
en-wikipedia-org-3485	744	21	dimethyltransferase	dimethyltransferase	NNP
en-wikipedia-org-3485	744	22	acting	act	VBG
en-wikipedia-org-3485	744	23	on	on	IN
en-wikipedia-org-3485	744	24	the	the	DT
en-wikipedia-org-3485	744	25	histone	histone	NN
en-wikipedia-org-3485	744	26	H3	h3	NN
en-wikipedia-org-3485	744	27	.	.	.
en-wikipedia-org-3485	745	1	A	a	DT
en-wikipedia-org-3485	745	2	feedback	feedback	NN
en-wikipedia-org-3485	745	3	mechanism	mechanism	NN
en-wikipedia-org-3485	745	4	can	can	MD
en-wikipedia-org-3485	745	5	be	be	VB
en-wikipedia-org-3485	745	6	observed	observe	VBN
en-wikipedia-org-3485	745	7	in	in	IN
en-wikipedia-org-3485	745	8	the	the	DT
en-wikipedia-org-3485	745	9	regulation	regulation	NN
en-wikipedia-org-3485	745	10	of	of	IN
en-wikipedia-org-3485	745	11	these	these	DT
en-wikipedia-org-3485	745	12	2	2	CD
en-wikipedia-org-3485	745	13	crucial	crucial	JJ
en-wikipedia-org-3485	745	14	factors	factor	NNS
en-wikipedia-org-3485	745	15	that	that	WDT
en-wikipedia-org-3485	745	16	determine	determine	VBP
en-wikipedia-org-3485	745	17	the	the	DT
en-wikipedia-org-3485	745	18	adaptive	adaptive	JJ
en-wikipedia-org-3485	745	19	epigenetic	epigenetic	JJ
en-wikipedia-org-3485	745	20	response	response	NN
en-wikipedia-org-3485	745	21	to	to	IN
en-wikipedia-org-3485	745	22	cocaine	cocaine	NN
en-wikipedia-org-3485	745	23	.	.	.
en-wikipedia-org-3485	746	1	This	this	DT
en-wikipedia-org-3485	746	2	depends	depend	VBZ
en-wikipedia-org-3485	746	3	on	on	IN
en-wikipedia-org-3485	746	4	ΔFosB	ΔFosB	NNS
en-wikipedia-org-3485	746	5	inhibiting	inhibit	VBG
en-wikipedia-org-3485	746	6	G9a	G9a	NNP
en-wikipedia-org-3485	746	7	gene	gene	NN
en-wikipedia-org-3485	746	8	expression	expression	NN
en-wikipedia-org-3485	746	9	,	,	,
en-wikipedia-org-3485	746	10	i.e.	i.e.	FW
en-wikipedia-org-3485	747	1	H3K9me2	h3k9me2	JJ
en-wikipedia-org-3485	747	2	synthesis	synthesis	NN
en-wikipedia-org-3485	747	3	which	which	WDT
en-wikipedia-org-3485	747	4	in	in	IN
en-wikipedia-org-3485	747	5	turn	turn	NN
en-wikipedia-org-3485	747	6	inhibits	inhibit	VBZ
en-wikipedia-org-3485	747	7	transcription	transcription	NN
en-wikipedia-org-3485	747	8	factors	factor	NNS
en-wikipedia-org-3485	747	9	for	for	IN
en-wikipedia-org-3485	747	10	ΔFosB.	δfosb.	ADD
en-wikipedia-org-3485	748	1	For	for	IN
en-wikipedia-org-3485	748	2	this	this	DT
en-wikipedia-org-3485	748	3	reason	reason	NN
en-wikipedia-org-3485	748	4	,	,	,
en-wikipedia-org-3485	748	5	the	the	DT
en-wikipedia-org-3485	748	6	observed	observed	JJ
en-wikipedia-org-3485	748	7	hyper	hyper	JJ
en-wikipedia-org-3485	748	8	-	-	NN
en-wikipedia-org-3485	748	9	expression	expression	NN
en-wikipedia-org-3485	748	10	of	of	IN
en-wikipedia-org-3485	748	11	G9a	G9a	NNP
en-wikipedia-org-3485	748	12	,	,	,
en-wikipedia-org-3485	748	13	which	which	WDT
en-wikipedia-org-3485	748	14	ensures	ensure	VBZ
en-wikipedia-org-3485	748	15	high	high	JJ
en-wikipedia-org-3485	748	16	levels	level	NNS
en-wikipedia-org-3485	748	17	of	of	IN
en-wikipedia-org-3485	748	18	the	the	DT
en-wikipedia-org-3485	748	19	dimethylated	dimethylate	VBN
en-wikipedia-org-3485	748	20	form	form	NN
en-wikipedia-org-3485	748	21	of	of	IN
en-wikipedia-org-3485	748	22	histone	histone	NN
en-wikipedia-org-3485	748	23	H3	H3	NNP
en-wikipedia-org-3485	748	24	,	,	,
en-wikipedia-org-3485	748	25	eliminates	eliminate	VBZ
en-wikipedia-org-3485	748	26	the	the	DT
en-wikipedia-org-3485	748	27	neuronal	neuronal	JJ
en-wikipedia-org-3485	748	28	structural	structural	JJ
en-wikipedia-org-3485	748	29	and	and	CC
en-wikipedia-org-3485	748	30	plasticity	plasticity	NN
en-wikipedia-org-3485	748	31	effects	effect	NNS
en-wikipedia-org-3485	748	32	caused	cause	VBN
en-wikipedia-org-3485	748	33	by	by	IN
en-wikipedia-org-3485	748	34	cocaine	cocaine	NN
en-wikipedia-org-3485	748	35	by	by	IN
en-wikipedia-org-3485	748	36	means	mean	NNS
en-wikipedia-org-3485	748	37	of	of	IN
en-wikipedia-org-3485	748	38	this	this	DT
en-wikipedia-org-3485	748	39	feedback	feedback	NN
en-wikipedia-org-3485	748	40	which	which	WDT
en-wikipedia-org-3485	748	41	blocks	block	VBZ
en-wikipedia-org-3485	748	42	ΔFosB	δfosb	JJ
en-wikipedia-org-3485	748	43	transcription	transcription	NN
en-wikipedia-org-3485	748	44	^	^	.
en-wikipedia-org-3485	748	45	Pitchers	Pitchers	NNP
en-wikipedia-org-3485	748	46	KK	KK	NNP
en-wikipedia-org-3485	748	47	,	,	,
en-wikipedia-org-3485	748	48	Vialou	Vialou	NNP
en-wikipedia-org-3485	748	49	V	V	NNP
en-wikipedia-org-3485	748	50	,	,	,
en-wikipedia-org-3485	748	51	Nestler	Nestler	NNP
en-wikipedia-org-3485	748	52	EJ	EJ	NNP
en-wikipedia-org-3485	748	53	,	,	,
en-wikipedia-org-3485	748	54	Laviolette	Laviolette	NNP
en-wikipedia-org-3485	748	55	SR	SR	NNP
en-wikipedia-org-3485	748	56	,	,	,
en-wikipedia-org-3485	748	57	Lehman	Lehman	NNP
en-wikipedia-org-3485	748	58	MN	MN	NNP
en-wikipedia-org-3485	748	59	,	,	,
en-wikipedia-org-3485	748	60	Coolen	Coolen	NNP
en-wikipedia-org-3485	748	61	LM	LM	NNP
en-wikipedia-org-3485	748	62	(	(	-LRB-
en-wikipedia-org-3485	748	63	February	February	NNP
en-wikipedia-org-3485	748	64	2013	2013	CD
en-wikipedia-org-3485	748	65	)	)	-RRB-
en-wikipedia-org-3485	748	66	.	.	.
en-wikipedia-org-3485	749	1	"	"	``
en-wikipedia-org-3485	749	2	Natural	natural	JJ
en-wikipedia-org-3485	749	3	and	and	CC
en-wikipedia-org-3485	749	4	drug	drug	NN
en-wikipedia-org-3485	749	5	rewards	reward	NNS
en-wikipedia-org-3485	749	6	act	act	VBP
en-wikipedia-org-3485	749	7	on	on	IN
en-wikipedia-org-3485	749	8	common	common	JJ
en-wikipedia-org-3485	749	9	neural	neural	JJ
en-wikipedia-org-3485	749	10	plasticity	plasticity	NN
en-wikipedia-org-3485	749	11	mechanisms	mechanism	NNS
en-wikipedia-org-3485	749	12	with	with	IN
en-wikipedia-org-3485	749	13	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	749	14	as	as	IN
en-wikipedia-org-3485	749	15	a	a	DT
en-wikipedia-org-3485	749	16	key	key	JJ
en-wikipedia-org-3485	749	17	mediator	mediator	NN
en-wikipedia-org-3485	749	18	"	"	''
en-wikipedia-org-3485	749	19	.	.	.
en-wikipedia-org-3485	750	1	The	the	DT
en-wikipedia-org-3485	750	2	Journal	Journal	NNP
en-wikipedia-org-3485	750	3	of	of	IN
en-wikipedia-org-3485	750	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	750	5	.	.	.
en-wikipedia-org-3485	751	1	33	33	CD
en-wikipedia-org-3485	751	2	(	(	-LRB-
en-wikipedia-org-3485	751	3	8)	8)	CD
en-wikipedia-org-3485	751	4	:	:	SYM
en-wikipedia-org-3485	751	5	3434–3442	3434–3442	CD
en-wikipedia-org-3485	751	6	.	.	.
en-wikipedia-org-3485	752	1	doi:10.1523	doi:10.1523	NNP
en-wikipedia-org-3485	752	2	/	/	SYM
en-wikipedia-org-3485	752	3	JNEUROSCI.4881	JNEUROSCI.4881	NNP
en-wikipedia-org-3485	752	4	-	-	:
en-wikipedia-org-3485	752	5	12.2013	12.2013	CD
en-wikipedia-org-3485	752	6	.	.	.
en-wikipedia-org-3485	753	1	PMC	PMC	NNP
en-wikipedia-org-3485	753	2	 	  	_SP
en-wikipedia-org-3485	753	3	3865508	3865508	CD
en-wikipedia-org-3485	753	4	.	.	.
en-wikipedia-org-3485	754	1	PMID	PMID	NNP
en-wikipedia-org-3485	754	2	 	  	_SP
en-wikipedia-org-3485	754	3	23426671	23426671	CD
en-wikipedia-org-3485	754	4	.	.	.
en-wikipedia-org-3485	755	1	Drugs	drug	NNS
en-wikipedia-org-3485	755	2	of	of	IN
en-wikipedia-org-3485	755	3	abuse	abuse	NN
en-wikipedia-org-3485	755	4	induce	induce	VBP
en-wikipedia-org-3485	755	5	neuroplasticity	neuroplasticity	NN
en-wikipedia-org-3485	755	6	in	in	IN
en-wikipedia-org-3485	755	7	the	the	DT
en-wikipedia-org-3485	755	8	natural	natural	JJ
en-wikipedia-org-3485	755	9	reward	reward	NN
en-wikipedia-org-3485	755	10	pathway	pathway	NNP
en-wikipedia-org-3485	755	11	,	,	,
en-wikipedia-org-3485	755	12	specifically	specifically	RB
en-wikipedia-org-3485	755	13	the	the	DT
en-wikipedia-org-3485	755	14	nucleus	nucleus	NN
en-wikipedia-org-3485	755	15	accumbens	accumben	NNS
en-wikipedia-org-3485	755	16	(	(	-LRB-
en-wikipedia-org-3485	755	17	NAc	NAc	NNS
en-wikipedia-org-3485	755	18	)	)	-RRB-
en-wikipedia-org-3485	755	19	,	,	,
en-wikipedia-org-3485	755	20	thereby	thereby	RB
en-wikipedia-org-3485	755	21	causing	cause	VBG
en-wikipedia-org-3485	755	22	development	development	NN
en-wikipedia-org-3485	755	23	and	and	CC
en-wikipedia-org-3485	755	24	expression	expression	NN
en-wikipedia-org-3485	755	25	of	of	IN
en-wikipedia-org-3485	755	26	addictive	addictive	JJ
en-wikipedia-org-3485	755	27	behavior	behavior	NN
en-wikipedia-org-3485	755	28	.	.	.
en-wikipedia-org-3485	756	1	...	...	NFP
en-wikipedia-org-3485	757	1	Together	together	RB
en-wikipedia-org-3485	757	2	,	,	,
en-wikipedia-org-3485	757	3	these	these	DT
en-wikipedia-org-3485	757	4	findings	finding	NNS
en-wikipedia-org-3485	757	5	demonstrate	demonstrate	VBP
en-wikipedia-org-3485	757	6	that	that	IN
en-wikipedia-org-3485	757	7	drugs	drug	NNS
en-wikipedia-org-3485	757	8	of	of	IN
en-wikipedia-org-3485	757	9	abuse	abuse	NN
en-wikipedia-org-3485	757	10	and	and	CC
en-wikipedia-org-3485	757	11	natural	natural	JJ
en-wikipedia-org-3485	757	12	reward	reward	NNP
en-wikipedia-org-3485	757	13	behaviors	behavior	NNS
en-wikipedia-org-3485	757	14	act	act	VBP
en-wikipedia-org-3485	757	15	on	on	IN
en-wikipedia-org-3485	757	16	common	common	JJ
en-wikipedia-org-3485	757	17	molecular	molecular	JJ
en-wikipedia-org-3485	757	18	and	and	CC
en-wikipedia-org-3485	757	19	cellular	cellular	JJ
en-wikipedia-org-3485	757	20	mechanisms	mechanism	NNS
en-wikipedia-org-3485	757	21	of	of	IN
en-wikipedia-org-3485	757	22	plasticity	plasticity	NN
en-wikipedia-org-3485	757	23	that	that	WDT
en-wikipedia-org-3485	757	24	control	control	VBP
en-wikipedia-org-3485	757	25	vulnerability	vulnerability	NN
en-wikipedia-org-3485	757	26	to	to	IN
en-wikipedia-org-3485	757	27	drug	drug	NN
en-wikipedia-org-3485	757	28	addiction	addiction	NN
en-wikipedia-org-3485	757	29	,	,	,
en-wikipedia-org-3485	757	30	and	and	CC
en-wikipedia-org-3485	757	31	that	that	IN
en-wikipedia-org-3485	757	32	this	this	DT
en-wikipedia-org-3485	757	33	increased	increase	VBN
en-wikipedia-org-3485	757	34	vulnerability	vulnerability	NN
en-wikipedia-org-3485	757	35	is	be	VBZ
en-wikipedia-org-3485	757	36	mediated	mediate	VBN
en-wikipedia-org-3485	757	37	by	by	IN
en-wikipedia-org-3485	757	38	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	757	39	and	and	CC
en-wikipedia-org-3485	757	40	its	-PRON-	PRP$
en-wikipedia-org-3485	757	41	downstream	downstream	JJ
en-wikipedia-org-3485	757	42	transcriptional	transcriptional	JJ
en-wikipedia-org-3485	757	43	targets	target	NNS
en-wikipedia-org-3485	757	44	.	.	.
en-wikipedia-org-3485	758	1	...	...	NFP
en-wikipedia-org-3485	759	1	Sexual	sexual	JJ
en-wikipedia-org-3485	759	2	behavior	behavior	NN
en-wikipedia-org-3485	759	3	is	be	VBZ
en-wikipedia-org-3485	759	4	highly	highly	RB
en-wikipedia-org-3485	759	5	rewarding	rewarding	JJ
en-wikipedia-org-3485	759	6	(	(	-LRB-
en-wikipedia-org-3485	759	7	Tenk	Tenk	NNPS
en-wikipedia-org-3485	759	8	et	et	FW
en-wikipedia-org-3485	759	9	al	al	NNP
en-wikipedia-org-3485	759	10	.	.	NNP
en-wikipedia-org-3485	759	11	,	,	,
en-wikipedia-org-3485	759	12	2009	2009	CD
en-wikipedia-org-3485	759	13	)	)	-RRB-
en-wikipedia-org-3485	759	14	,	,	,
en-wikipedia-org-3485	759	15	and	and	CC
en-wikipedia-org-3485	759	16	sexual	sexual	JJ
en-wikipedia-org-3485	759	17	experience	experience	NN
en-wikipedia-org-3485	759	18	causes	cause	NNS
en-wikipedia-org-3485	759	19	sensitized	sensitized	JJ
en-wikipedia-org-3485	759	20	drug	drug	NN
en-wikipedia-org-3485	759	21	-	-	HYPH
en-wikipedia-org-3485	759	22	related	relate	VBN
en-wikipedia-org-3485	759	23	behaviors	behavior	NNS
en-wikipedia-org-3485	759	24	,	,	,
en-wikipedia-org-3485	759	25	including	include	VBG
en-wikipedia-org-3485	759	26	cross	cross	NN
en-wikipedia-org-3485	759	27	-	-	NN
en-wikipedia-org-3485	759	28	sensitization	sensitization	NN
en-wikipedia-org-3485	759	29	to	to	TO
en-wikipedia-org-3485	759	30	amphetamine	amphetamine	VB
en-wikipedia-org-3485	759	31	(	(	-LRB-
en-wikipedia-org-3485	759	32	Amph)-induced	amph)-induced	JJ
en-wikipedia-org-3485	759	33	locomotor	locomotor	NN
en-wikipedia-org-3485	759	34	activity	activity	NN
en-wikipedia-org-3485	759	35	(	(	-LRB-
en-wikipedia-org-3485	759	36	Bradley	Bradley	NNP
en-wikipedia-org-3485	759	37	and	and	CC
en-wikipedia-org-3485	759	38	Meisel	Meisel	NNP
en-wikipedia-org-3485	759	39	,	,	,
en-wikipedia-org-3485	759	40	2001	2001	CD
en-wikipedia-org-3485	759	41	;	;	:
en-wikipedia-org-3485	759	42	Pitchers	Pitchers	NNP
en-wikipedia-org-3485	759	43	et	et	NNP
en-wikipedia-org-3485	759	44	al	al	NNP
en-wikipedia-org-3485	759	45	.	.	NNP
en-wikipedia-org-3485	759	46	,	,	,
en-wikipedia-org-3485	759	47	2010a	2010a	CD
en-wikipedia-org-3485	759	48	)	)	-RRB-
en-wikipedia-org-3485	759	49	and	and	CC
en-wikipedia-org-3485	759	50	enhanced	enhance	VBD
en-wikipedia-org-3485	759	51	Amph	Amph	NNP
en-wikipedia-org-3485	759	52	reward	reward	NN
en-wikipedia-org-3485	759	53	(	(	-LRB-
en-wikipedia-org-3485	759	54	Pitchers	Pitchers	NNPS
en-wikipedia-org-3485	759	55	et	et	NNP
en-wikipedia-org-3485	759	56	al	al	NNP
en-wikipedia-org-3485	759	57	.	.	NNP
en-wikipedia-org-3485	759	58	,	,	,
en-wikipedia-org-3485	759	59	2010a	2010a	CD
en-wikipedia-org-3485	759	60	)	)	-RRB-
en-wikipedia-org-3485	759	61	.	.	.
en-wikipedia-org-3485	760	1	Moreover	moreover	RB
en-wikipedia-org-3485	760	2	,	,	,
en-wikipedia-org-3485	760	3	sexual	sexual	JJ
en-wikipedia-org-3485	760	4	experience	experience	NN
en-wikipedia-org-3485	760	5	induces	induce	VBZ
en-wikipedia-org-3485	760	6	neural	neural	JJ
en-wikipedia-org-3485	760	7	plasticity	plasticity	NN
en-wikipedia-org-3485	760	8	in	in	IN
en-wikipedia-org-3485	760	9	the	the	DT
en-wikipedia-org-3485	760	10	NAc	NAc	NNS
en-wikipedia-org-3485	760	11	similar	similar	JJ
en-wikipedia-org-3485	760	12	to	to	IN
en-wikipedia-org-3485	760	13	that	that	DT
en-wikipedia-org-3485	760	14	induced	induce	VBN
en-wikipedia-org-3485	760	15	by	by	IN
en-wikipedia-org-3485	760	16	psychostimulant	psychostimulant	JJ
en-wikipedia-org-3485	760	17	exposure	exposure	NN
en-wikipedia-org-3485	760	18	,	,	,
en-wikipedia-org-3485	760	19	including	include	VBG
en-wikipedia-org-3485	760	20	increased	increase	VBN
en-wikipedia-org-3485	760	21	dendritic	dendritic	JJ
en-wikipedia-org-3485	760	22	spine	spine	NN
en-wikipedia-org-3485	760	23	density	density	NN
en-wikipedia-org-3485	760	24	(	(	-LRB-
en-wikipedia-org-3485	760	25	Meisel	Meisel	NNP
en-wikipedia-org-3485	760	26	and	and	CC
en-wikipedia-org-3485	760	27	Mullins	Mullins	NNP
en-wikipedia-org-3485	760	28	,	,	,
en-wikipedia-org-3485	760	29	2006	2006	CD
en-wikipedia-org-3485	760	30	;	;	:
en-wikipedia-org-3485	760	31	Pitchers	Pitchers	NNP
en-wikipedia-org-3485	760	32	et	et	NNP
en-wikipedia-org-3485	760	33	al	al	NNP
en-wikipedia-org-3485	760	34	.	.	NNP
en-wikipedia-org-3485	760	35	,	,	,
en-wikipedia-org-3485	760	36	2010a	2010a	CD
en-wikipedia-org-3485	760	37	)	)	-RRB-
en-wikipedia-org-3485	760	38	,	,	,
en-wikipedia-org-3485	760	39	altered	alter	VBN
en-wikipedia-org-3485	760	40	glutamate	glutamate	JJ
en-wikipedia-org-3485	760	41	receptor	receptor	NN
en-wikipedia-org-3485	760	42	trafficking	trafficking	NN
en-wikipedia-org-3485	760	43	,	,	,
en-wikipedia-org-3485	760	44	and	and	CC
en-wikipedia-org-3485	760	45	decreased	decrease	VBD
en-wikipedia-org-3485	760	46	synaptic	synaptic	JJ
en-wikipedia-org-3485	760	47	strength	strength	NN
en-wikipedia-org-3485	760	48	in	in	IN
en-wikipedia-org-3485	760	49	prefrontal	prefrontal	JJ
en-wikipedia-org-3485	760	50	cortex	cortex	NN
en-wikipedia-org-3485	760	51	-	-	HYPH
en-wikipedia-org-3485	760	52	responding	respond	VBG
en-wikipedia-org-3485	760	53	NAc	NAc	NNP
en-wikipedia-org-3485	760	54	shell	shell	NN
en-wikipedia-org-3485	760	55	neurons	neuron	NNS
en-wikipedia-org-3485	760	56	(	(	-LRB-
en-wikipedia-org-3485	760	57	Pitchers	Pitchers	NNPS
en-wikipedia-org-3485	760	58	et	et	NNP
en-wikipedia-org-3485	760	59	al	al	NNP
en-wikipedia-org-3485	760	60	.	.	NNP
en-wikipedia-org-3485	760	61	,	,	,
en-wikipedia-org-3485	760	62	2012	2012	CD
en-wikipedia-org-3485	760	63	)	)	-RRB-
en-wikipedia-org-3485	760	64	.	.	.
en-wikipedia-org-3485	761	1	Finally	finally	RB
en-wikipedia-org-3485	761	2	,	,	,
en-wikipedia-org-3485	761	3	periods	period	NNS
en-wikipedia-org-3485	761	4	of	of	IN
en-wikipedia-org-3485	761	5	abstinence	abstinence	NN
en-wikipedia-org-3485	761	6	from	from	IN
en-wikipedia-org-3485	761	7	sexual	sexual	JJ
en-wikipedia-org-3485	761	8	experience	experience	NN
en-wikipedia-org-3485	761	9	were	be	VBD
en-wikipedia-org-3485	761	10	found	find	VBN
en-wikipedia-org-3485	761	11	to	to	TO
en-wikipedia-org-3485	761	12	be	be	VB
en-wikipedia-org-3485	761	13	critical	critical	JJ
en-wikipedia-org-3485	761	14	for	for	IN
en-wikipedia-org-3485	761	15	enhanced	enhanced	JJ
en-wikipedia-org-3485	761	16	Amph	Amph	NNP
en-wikipedia-org-3485	761	17	reward	reward	NN
en-wikipedia-org-3485	761	18	,	,	,
en-wikipedia-org-3485	761	19	NAc	NAc	NNS
en-wikipedia-org-3485	761	20	spinogenesis	spinogenesis	NN
en-wikipedia-org-3485	761	21	(	(	-LRB-
en-wikipedia-org-3485	761	22	Pitchers	Pitchers	NNPS
en-wikipedia-org-3485	761	23	et	et	NNP
en-wikipedia-org-3485	761	24	al	al	NNP
en-wikipedia-org-3485	761	25	.	.	NNP
en-wikipedia-org-3485	761	26	,	,	,
en-wikipedia-org-3485	761	27	2010a	2010a	CD
en-wikipedia-org-3485	761	28	)	)	-RRB-
en-wikipedia-org-3485	761	29	,	,	,
en-wikipedia-org-3485	761	30	and	and	CC
en-wikipedia-org-3485	761	31	glutamate	glutamate	JJ
en-wikipedia-org-3485	761	32	receptor	receptor	NN
en-wikipedia-org-3485	761	33	trafficking	trafficking	NN
en-wikipedia-org-3485	761	34	(	(	-LRB-
en-wikipedia-org-3485	761	35	Pitchers	Pitchers	NNPS
en-wikipedia-org-3485	761	36	et	et	NNP
en-wikipedia-org-3485	761	37	al	al	NNP
en-wikipedia-org-3485	761	38	.	.	NNP
en-wikipedia-org-3485	761	39	,	,	,
en-wikipedia-org-3485	761	40	2012	2012	CD
en-wikipedia-org-3485	761	41	)	)	-RRB-
en-wikipedia-org-3485	761	42	.	.	.
en-wikipedia-org-3485	762	1	These	these	DT
en-wikipedia-org-3485	762	2	findings	finding	NNS
en-wikipedia-org-3485	762	3	suggest	suggest	VBP
en-wikipedia-org-3485	762	4	that	that	IN
en-wikipedia-org-3485	762	5	natural	natural	JJ
en-wikipedia-org-3485	762	6	and	and	CC
en-wikipedia-org-3485	762	7	drug	drug	NN
en-wikipedia-org-3485	762	8	reward	reward	NN
en-wikipedia-org-3485	762	9	experiences	experience	NNS
en-wikipedia-org-3485	762	10	share	share	VBP
en-wikipedia-org-3485	762	11	common	common	JJ
en-wikipedia-org-3485	762	12	mechanisms	mechanism	NNS
en-wikipedia-org-3485	762	13	of	of	IN
en-wikipedia-org-3485	762	14	neural	neural	JJ
en-wikipedia-org-3485	762	15	plasticity	plasticity	NN
en-wikipedia-org-3485	762	16	^	^	.
en-wikipedia-org-3485	762	17	Beloate	Beloate	NNP
en-wikipedia-org-3485	762	18	LN	LN	NNP
en-wikipedia-org-3485	762	19	,	,	,
en-wikipedia-org-3485	762	20	Weems	Weems	NNP
en-wikipedia-org-3485	762	21	PW	PW	NNP
en-wikipedia-org-3485	762	22	,	,	,
en-wikipedia-org-3485	762	23	Casey	Casey	NNP
en-wikipedia-org-3485	762	24	GR	GR	NNP
en-wikipedia-org-3485	762	25	,	,	,
en-wikipedia-org-3485	762	26	Webb	Webb	NNP
en-wikipedia-org-3485	762	27	IC	IC	NNP
en-wikipedia-org-3485	762	28	,	,	,
en-wikipedia-org-3485	762	29	Coolen	Coolen	NNP
en-wikipedia-org-3485	762	30	LM	LM	NNP
en-wikipedia-org-3485	762	31	(	(	-LRB-
en-wikipedia-org-3485	762	32	February	February	NNP
en-wikipedia-org-3485	762	33	2016	2016	CD
en-wikipedia-org-3485	762	34	)	)	-RRB-
en-wikipedia-org-3485	762	35	.	.	.
en-wikipedia-org-3485	763	1	"	"	``
en-wikipedia-org-3485	763	2	Nucleus	Nucleus	NNP
en-wikipedia-org-3485	763	3	accumbens	accumben	VBZ
en-wikipedia-org-3485	763	4	NMDA	NMDA	NNP
en-wikipedia-org-3485	763	5	receptor	receptor	NN
en-wikipedia-org-3485	763	6	activation	activation	NN
en-wikipedia-org-3485	763	7	regulates	regulate	NNS
en-wikipedia-org-3485	763	8	amphetamine	amphetamine	NNP
en-wikipedia-org-3485	763	9	cross	cross	JJ
en-wikipedia-org-3485	763	10	-	-	JJ
en-wikipedia-org-3485	763	11	sensitization	sensitization	JJ
en-wikipedia-org-3485	763	12	and	and	CC
en-wikipedia-org-3485	763	13	deltaFosB	deltaFosB	VBZ
en-wikipedia-org-3485	763	14	expression	expression	NN
en-wikipedia-org-3485	763	15	following	follow	VBG
en-wikipedia-org-3485	763	16	sexual	sexual	JJ
en-wikipedia-org-3485	763	17	experience	experience	NN
en-wikipedia-org-3485	763	18	in	in	IN
en-wikipedia-org-3485	763	19	male	male	JJ
en-wikipedia-org-3485	763	20	rats	rat	NNS
en-wikipedia-org-3485	763	21	"	"	''
en-wikipedia-org-3485	763	22	.	.	.
en-wikipedia-org-3485	764	1	Neuropharmacology	neuropharmacology	NN
en-wikipedia-org-3485	764	2	.	.	.
en-wikipedia-org-3485	765	1	101	101	CD
en-wikipedia-org-3485	765	2	:	:	SYM
en-wikipedia-org-3485	765	3	154–164	154–164	CD
en-wikipedia-org-3485	765	4	.	.	.
en-wikipedia-org-3485	766	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	766	2	/	/	SYM
en-wikipedia-org-3485	766	3	j.neuropharm.2015.09.023	j.neuropharm.2015.09.023	JJ
en-wikipedia-org-3485	766	4	.	.	.
en-wikipedia-org-3485	767	1	PMID	PMID	NNP
en-wikipedia-org-3485	767	2	 	  	_SP
en-wikipedia-org-3485	767	3	26391065	26391065	CD
en-wikipedia-org-3485	767	4	.	.	.
en-wikipedia-org-3485	768	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	768	2	 	  	_SP
en-wikipedia-org-3485	768	3	25317397	25317397	CD
en-wikipedia-org-3485	768	4	.	.	.
en-wikipedia-org-3485	769	1	^	^	NNP
en-wikipedia-org-3485	769	2	Robison	Robison	NNP
en-wikipedia-org-3485	769	3	AJ	AJ	NNP
en-wikipedia-org-3485	769	4	,	,	,
en-wikipedia-org-3485	769	5	Nestler	Nestler	NNP
en-wikipedia-org-3485	769	6	EJ	EJ	NNP
en-wikipedia-org-3485	769	7	(	(	-LRB-
en-wikipedia-org-3485	769	8	November	November	NNP
en-wikipedia-org-3485	769	9	2011	2011	CD
en-wikipedia-org-3485	769	10	)	)	-RRB-
en-wikipedia-org-3485	769	11	.	.	.
en-wikipedia-org-3485	770	1	"	"	``
en-wikipedia-org-3485	770	2	Transcriptional	transcriptional	JJ
en-wikipedia-org-3485	770	3	and	and	CC
en-wikipedia-org-3485	770	4	epigenetic	epigenetic	JJ
en-wikipedia-org-3485	770	5	mechanisms	mechanism	NNS
en-wikipedia-org-3485	770	6	of	of	IN
en-wikipedia-org-3485	770	7	addiction	addiction	NN
en-wikipedia-org-3485	770	8	"	"	''
en-wikipedia-org-3485	770	9	.	.	.
en-wikipedia-org-3485	771	1	Nat	Nat	NNP
en-wikipedia-org-3485	771	2	.	.	.
en-wikipedia-org-3485	772	1	Rev.	Rev.	NNP
en-wikipedia-org-3485	773	1	Neurosci	Neurosci	NNP
en-wikipedia-org-3485	773	2	.	.	.
en-wikipedia-org-3485	774	1	12	12	CD
en-wikipedia-org-3485	774	2	(	(	-LRB-
en-wikipedia-org-3485	774	3	11	11	CD
en-wikipedia-org-3485	774	4	)	)	-RRB-
en-wikipedia-org-3485	774	5	:	:	:
en-wikipedia-org-3485	774	6	623–637	623–637	CD
en-wikipedia-org-3485	774	7	.	.	.
en-wikipedia-org-3485	775	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-3485	775	2	/	/	SYM
en-wikipedia-org-3485	775	3	nrn3111	nrn3111	NNP
en-wikipedia-org-3485	775	4	.	.	.
en-wikipedia-org-3485	776	1	PMC	PMC	NNP
en-wikipedia-org-3485	776	2	 	  	_SP
en-wikipedia-org-3485	776	3	3272277	3272277	CD
en-wikipedia-org-3485	776	4	.	.	.
en-wikipedia-org-3485	777	1	PMID	PMID	NNP
en-wikipedia-org-3485	777	2	 	  	_SP
en-wikipedia-org-3485	777	3	21989194	21989194	CD
en-wikipedia-org-3485	777	4	.	.	.
en-wikipedia-org-3485	778	1	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	778	2	serves	serve	VBZ
en-wikipedia-org-3485	778	3	as	as	IN
en-wikipedia-org-3485	778	4	one	one	CD
en-wikipedia-org-3485	778	5	of	of	IN
en-wikipedia-org-3485	778	6	the	the	DT
en-wikipedia-org-3485	778	7	master	master	NN
en-wikipedia-org-3485	778	8	control	control	NN
en-wikipedia-org-3485	778	9	proteins	protein	NNS
en-wikipedia-org-3485	778	10	governing	govern	VBG
en-wikipedia-org-3485	778	11	this	this	DT
en-wikipedia-org-3485	778	12	structural	structural	JJ
en-wikipedia-org-3485	778	13	plasticity	plasticity	NN
en-wikipedia-org-3485	778	14	.	.	.
en-wikipedia-org-3485	779	1	...	...	NFP
en-wikipedia-org-3485	779	2	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	779	3	also	also	RB
en-wikipedia-org-3485	779	4	represses	repress	VBZ
en-wikipedia-org-3485	779	5	G9a	G9a	NNP
en-wikipedia-org-3485	779	6	expression	expression	NN
en-wikipedia-org-3485	779	7	,	,	,
en-wikipedia-org-3485	779	8	leading	lead	VBG
en-wikipedia-org-3485	779	9	to	to	IN
en-wikipedia-org-3485	779	10	reduced	reduce	VBN
en-wikipedia-org-3485	779	11	repressive	repressive	JJ
en-wikipedia-org-3485	779	12	histone	histone	NN
en-wikipedia-org-3485	779	13	methylation	methylation	NN
en-wikipedia-org-3485	779	14	at	at	IN
en-wikipedia-org-3485	779	15	the	the	DT
en-wikipedia-org-3485	779	16	cdk5	cdk5	NNP
en-wikipedia-org-3485	779	17	gene	gene	NN
en-wikipedia-org-3485	779	18	.	.	.
en-wikipedia-org-3485	780	1	The	the	DT
en-wikipedia-org-3485	780	2	net	net	JJ
en-wikipedia-org-3485	780	3	result	result	NN
en-wikipedia-org-3485	780	4	is	be	VBZ
en-wikipedia-org-3485	780	5	gene	gene	NN
en-wikipedia-org-3485	780	6	activation	activation	NN
en-wikipedia-org-3485	780	7	and	and	CC
en-wikipedia-org-3485	780	8	increased	increase	VBD
en-wikipedia-org-3485	780	9	CDK5	CDK5	NNP
en-wikipedia-org-3485	780	10	expression	expression	NN
en-wikipedia-org-3485	780	11	.	.	.
en-wikipedia-org-3485	781	1	...	...	NFP
en-wikipedia-org-3485	782	1	In	in	IN
en-wikipedia-org-3485	782	2	contrast	contrast	NN
en-wikipedia-org-3485	782	3	,	,	,
en-wikipedia-org-3485	782	4	ΔFosB	ΔFosB	VBZ
en-wikipedia-org-3485	782	5	binds	bind	NNS
en-wikipedia-org-3485	782	6	to	to	IN
en-wikipedia-org-3485	782	7	the	the	DT
en-wikipedia-org-3485	782	8	c	c	NN
en-wikipedia-org-3485	782	9	-	-	HYPH
en-wikipedia-org-3485	782	10	fos	fos	NN
en-wikipedia-org-3485	782	11	gene	gene	NN
en-wikipedia-org-3485	782	12	and	and	CC
en-wikipedia-org-3485	782	13	recruits	recruit	VBZ
en-wikipedia-org-3485	782	14	several	several	JJ
en-wikipedia-org-3485	782	15	co	co	NNS
en-wikipedia-org-3485	782	16	-	-	NNS
en-wikipedia-org-3485	782	17	repressors	repressor	NNS
en-wikipedia-org-3485	782	18	,	,	,
en-wikipedia-org-3485	782	19	including	include	VBG
en-wikipedia-org-3485	782	20	HDAC1	HDAC1	NNP
en-wikipedia-org-3485	782	21	(	(	-LRB-
en-wikipedia-org-3485	782	22	histone	histone	NNP
en-wikipedia-org-3485	782	23	deacetylase	deacetylase	NN
en-wikipedia-org-3485	782	24	1	1	CD
en-wikipedia-org-3485	782	25	)	)	-RRB-
en-wikipedia-org-3485	782	26	and	and	CC
en-wikipedia-org-3485	782	27	SIRT	SIRT	NNP
en-wikipedia-org-3485	782	28	1	1	CD
en-wikipedia-org-3485	782	29	(	(	-LRB-
en-wikipedia-org-3485	782	30	sirtuin	sirtuin	NN
en-wikipedia-org-3485	782	31	1	1	CD
en-wikipedia-org-3485	782	32	)	)	-RRB-
en-wikipedia-org-3485	782	33	.	.	.
en-wikipedia-org-3485	783	1	...	...	NFP
en-wikipedia-org-3485	784	1	The	the	DT
en-wikipedia-org-3485	784	2	net	net	JJ
en-wikipedia-org-3485	784	3	result	result	NN
en-wikipedia-org-3485	784	4	is	be	VBZ
en-wikipedia-org-3485	784	5	c	c	NN
en-wikipedia-org-3485	784	6	-	-	HYPH
en-wikipedia-org-3485	784	7	fos	fos	NN
en-wikipedia-org-3485	784	8	gene	gene	NN
en-wikipedia-org-3485	784	9	repression	repression	NN
en-wikipedia-org-3485	784	10	.	.	.
en-wikipedia-org-3485	785	1	Figure	figure	NN
en-wikipedia-org-3485	785	2	4	4	CD
en-wikipedia-org-3485	785	3	:	:	:
en-wikipedia-org-3485	785	4	Epigenetic	epigenetic	JJ
en-wikipedia-org-3485	785	5	basis	basis	NN
en-wikipedia-org-3485	785	6	of	of	IN
en-wikipedia-org-3485	785	7	drug	drug	NN
en-wikipedia-org-3485	785	8	regulation	regulation	NN
en-wikipedia-org-3485	785	9	of	of	IN
en-wikipedia-org-3485	785	10	gene	gene	NN
en-wikipedia-org-3485	785	11	expression	expression	NN
en-wikipedia-org-3485	785	12	^	^	.
en-wikipedia-org-3485	785	13	Hitchcock	Hitchcock	NNP
en-wikipedia-org-3485	785	14	LN	LN	NNP
en-wikipedia-org-3485	785	15	,	,	,
en-wikipedia-org-3485	785	16	Lattal	Lattal	NNP
en-wikipedia-org-3485	785	17	KM	KM	NNP
en-wikipedia-org-3485	785	18	(	(	-LRB-
en-wikipedia-org-3485	785	19	2014	2014	CD
en-wikipedia-org-3485	785	20	)	)	-RRB-
en-wikipedia-org-3485	785	21	.	.	.
en-wikipedia-org-3485	786	1	"	"	``
en-wikipedia-org-3485	786	2	Histone	histone	NN
en-wikipedia-org-3485	786	3	-	-	HYPH
en-wikipedia-org-3485	786	4	mediated	mediate	VBN
en-wikipedia-org-3485	786	5	epigenetics	epigenetic	NNS
en-wikipedia-org-3485	786	6	in	in	IN
en-wikipedia-org-3485	786	7	addiction	addiction	NN
en-wikipedia-org-3485	786	8	"	"	''
en-wikipedia-org-3485	786	9	.	.	.
en-wikipedia-org-3485	787	1	Epigenetics	Epigenetics	NNP
en-wikipedia-org-3485	787	2	and	and	CC
en-wikipedia-org-3485	787	3	Neuroplasticity	Neuroplasticity	NNP
en-wikipedia-org-3485	787	4	—	—	:
en-wikipedia-org-3485	787	5	Evidence	Evidence	NNP
en-wikipedia-org-3485	787	6	and	and	CC
en-wikipedia-org-3485	787	7	Debate	debate	NN
en-wikipedia-org-3485	787	8	.	.	.
en-wikipedia-org-3485	788	1	Prog	Prog	NNP
en-wikipedia-org-3485	788	2	Mol	Mol	NNP
en-wikipedia-org-3485	788	3	Biol	Biol	NNP
en-wikipedia-org-3485	788	4	Transl	Transl	NNP
en-wikipedia-org-3485	788	5	Sci	Sci	NNP
en-wikipedia-org-3485	788	6	.	.	.
en-wikipedia-org-3485	789	1	Progress	progress	NN
en-wikipedia-org-3485	789	2	in	in	IN
en-wikipedia-org-3485	789	3	Molecular	Molecular	NNP
en-wikipedia-org-3485	789	4	Biology	Biology	NNP
en-wikipedia-org-3485	789	5	and	and	CC
en-wikipedia-org-3485	789	6	Translational	Translational	NNP
en-wikipedia-org-3485	789	7	Science	Science	NNP
en-wikipedia-org-3485	789	8	.	.	.
en-wikipedia-org-3485	790	1	128	128	CD
en-wikipedia-org-3485	790	2	.	.	.
en-wikipedia-org-3485	790	3	pp	pp	NNP
en-wikipedia-org-3485	790	4	.	.	.
en-wikipedia-org-3485	791	1	51–87	51–87	LS
en-wikipedia-org-3485	791	2	.	.	.
en-wikipedia-org-3485	792	1	doi:10.1016	doi:10.1016	LS
en-wikipedia-org-3485	792	2	/	/	SYM
en-wikipedia-org-3485	792	3	B978	B978	NNP
en-wikipedia-org-3485	792	4	-	-	HYPH
en-wikipedia-org-3485	792	5	0	0	CD
en-wikipedia-org-3485	792	6	-	-	HYPH
en-wikipedia-org-3485	792	7	12	12	CD
en-wikipedia-org-3485	792	8	-	-	HYPH
en-wikipedia-org-3485	792	9	800977	800977	CD
en-wikipedia-org-3485	792	10	-	-	HYPH
en-wikipedia-org-3485	792	11	2.00003	2.00003	CD
en-wikipedia-org-3485	792	12	-	-	SYM
en-wikipedia-org-3485	792	13	6	6	CD
en-wikipedia-org-3485	792	14	.	.	.
en-wikipedia-org-3485	793	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	793	2	 	  	_SP
en-wikipedia-org-3485	793	3	9780128009772	9780128009772	CD
en-wikipedia-org-3485	793	4	.	.	.
en-wikipedia-org-3485	794	1	PMC	PMC	NNP
en-wikipedia-org-3485	794	2	 	  	_SP
en-wikipedia-org-3485	794	3	5914502	5914502	CD
en-wikipedia-org-3485	794	4	.	.	.
en-wikipedia-org-3485	795	1	PMID	PMID	NNP
en-wikipedia-org-3485	795	2	 	  	_SP
en-wikipedia-org-3485	795	3	25410541	25410541	CD
en-wikipedia-org-3485	795	4	.	.	.
en-wikipedia-org-3485	796	1	^	^	NFP
en-wikipedia-org-3485	796	2	Walker	Walker	NNP
en-wikipedia-org-3485	796	3	DM	DM	NNP
en-wikipedia-org-3485	796	4	,	,	,
en-wikipedia-org-3485	796	5	Nestler	Nestler	NNP
en-wikipedia-org-3485	796	6	EJ	EJ	NNP
en-wikipedia-org-3485	796	7	(	(	-LRB-
en-wikipedia-org-3485	796	8	2018	2018	CD
en-wikipedia-org-3485	796	9	)	)	-RRB-
en-wikipedia-org-3485	796	10	.	.	.
en-wikipedia-org-3485	797	1	"	"	``
en-wikipedia-org-3485	797	2	Neuroepigenetics	neuroepigenetic	NNS
en-wikipedia-org-3485	797	3	and	and	CC
en-wikipedia-org-3485	797	4	addiction	addiction	NN
en-wikipedia-org-3485	797	5	"	"	''
en-wikipedia-org-3485	797	6	.	.	.
en-wikipedia-org-3485	798	1	Neurogenetics	Neurogenetics	NNP
en-wikipedia-org-3485	798	2	,	,	,
en-wikipedia-org-3485	798	3	Part	Part	NNP
en-wikipedia-org-3485	798	4	II	II	NNP
en-wikipedia-org-3485	798	5	.	.	.
en-wikipedia-org-3485	799	1	Handbook	Handbook	NNP
en-wikipedia-org-3485	799	2	of	of	IN
en-wikipedia-org-3485	799	3	Clinical	Clinical	NNP
en-wikipedia-org-3485	799	4	Neurology	Neurology	NNP
en-wikipedia-org-3485	799	5	.	.	.
en-wikipedia-org-3485	800	1	148	148	CD
en-wikipedia-org-3485	800	2	.	.	.
en-wikipedia-org-3485	800	3	pp	pp	NNP
en-wikipedia-org-3485	800	4	.	.	.
en-wikipedia-org-3485	801	1	747–765	747–765	CD
en-wikipedia-org-3485	801	2	.	.	.
en-wikipedia-org-3485	802	1	doi:10.1016	doi:10.1016	LS
en-wikipedia-org-3485	802	2	/	/	SYM
en-wikipedia-org-3485	802	3	B978	B978	NNP
en-wikipedia-org-3485	802	4	-	-	HYPH
en-wikipedia-org-3485	802	5	0	0	CD
en-wikipedia-org-3485	802	6	-	-	HYPH
en-wikipedia-org-3485	802	7	444	444	CD
en-wikipedia-org-3485	802	8	-	-	HYPH
en-wikipedia-org-3485	802	9	64076	64076	CD
en-wikipedia-org-3485	802	10	-	-	HYPH
en-wikipedia-org-3485	802	11	5.00048-X.	5.00048-x.	CD
en-wikipedia-org-3485	803	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	803	2	 	  	_SP
en-wikipedia-org-3485	803	3	9780444640765	9780444640765	CD
en-wikipedia-org-3485	803	4	.	.	.
en-wikipedia-org-3485	804	1	PMC	PMC	NNP
en-wikipedia-org-3485	804	2	 	  	_SP
en-wikipedia-org-3485	804	3	5868351	5868351	CD
en-wikipedia-org-3485	804	4	.	.	.
en-wikipedia-org-3485	805	1	PMID	PMID	NNP
en-wikipedia-org-3485	805	2	 	  	_SP
en-wikipedia-org-3485	805	3	29478612	29478612	CD
en-wikipedia-org-3485	805	4	.	.	.
en-wikipedia-org-3485	806	1	^	^	NNP
en-wikipedia-org-3485	806	2	Rang	Rang	NNP
en-wikipedia-org-3485	806	3	HP	HP	NNP
en-wikipedia-org-3485	806	4	(	(	-LRB-
en-wikipedia-org-3485	806	5	2003	2003	CD
en-wikipedia-org-3485	806	6	)	)	-RRB-
en-wikipedia-org-3485	806	7	.	.	.
en-wikipedia-org-3485	807	1	Pharmacology	pharmacology	NN
en-wikipedia-org-3485	807	2	.	.	.
en-wikipedia-org-3485	808	1	Edinburgh	Edinburgh	NNP
en-wikipedia-org-3485	808	2	:	:	:
en-wikipedia-org-3485	808	3	Churchill	Churchill	NNP
en-wikipedia-org-3485	808	4	Livingstone	Livingstone	NNP
en-wikipedia-org-3485	808	5	.	.	.
en-wikipedia-org-3485	809	1	p.	p.	NN
en-wikipedia-org-3485	809	2	 	  	_SP
en-wikipedia-org-3485	809	3	596	596	CD
en-wikipedia-org-3485	809	4	.	.	.
en-wikipedia-org-3485	810	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	810	2	 	  	_SP
en-wikipedia-org-3485	810	3	978	978	CD
en-wikipedia-org-3485	810	4	-	-	HYPH
en-wikipedia-org-3485	810	5	0	0	CD
en-wikipedia-org-3485	810	6	-	-	HYPH
en-wikipedia-org-3485	810	7	443	443	CD
en-wikipedia-org-3485	810	8	-	-	HYPH
en-wikipedia-org-3485	810	9	07145	07145	CD
en-wikipedia-org-3485	810	10	-	-	HYPH
en-wikipedia-org-3485	810	11	4	4	CD
en-wikipedia-org-3485	810	12	.	.	.
en-wikipedia-org-3485	811	1	^	^	NNP
en-wikipedia-org-3485	811	2	a	a	DT
en-wikipedia-org-3485	811	3	b	b	NN
en-wikipedia-org-3485	811	4	Roy	Roy	NNP
en-wikipedia-org-3485	811	5	A.	a.	NN
en-wikipedia-org-3485	812	1	Wise	wise	JJ
en-wikipedia-org-3485	812	2	,	,	,
en-wikipedia-org-3485	812	3	Drug	drug	NN
en-wikipedia-org-3485	812	4	-	-	HYPH
en-wikipedia-org-3485	812	5	activation	activation	NN
en-wikipedia-org-3485	812	6	of	of	IN
en-wikipedia-org-3485	812	7	brain	brain	NN
en-wikipedia-org-3485	812	8	reward	reward	NN
en-wikipedia-org-3485	812	9	pathways	pathway	NNS
en-wikipedia-org-3485	812	10	,	,	,
en-wikipedia-org-3485	812	11	Drug	Drug	NNP
en-wikipedia-org-3485	812	12	and	and	CC
en-wikipedia-org-3485	812	13	Alcohol	Alcohol	NNP
en-wikipedia-org-3485	812	14	Dependence	Dependence	NNP
en-wikipedia-org-3485	812	15	1998	1998	CD
en-wikipedia-org-3485	812	16	;	;	:
en-wikipedia-org-3485	812	17	51	51	CD
en-wikipedia-org-3485	812	18	13–22	13–22	CD
en-wikipedia-org-3485	812	19	.	.	.
en-wikipedia-org-3485	813	1	^	^	NFP
en-wikipedia-org-3485	813	2	Goeders	Goeders	NNP
en-wikipedia-org-3485	813	3	N.E.	N.E.	NNP
en-wikipedia-org-3485	813	4	,	,	,
en-wikipedia-org-3485	813	5	Smith	Smith	NNP
en-wikipedia-org-3485	813	6	J.E.	J.E.	NNP
en-wikipedia-org-3485	814	1	(	(	-LRB-
en-wikipedia-org-3485	814	2	1983	1983	CD
en-wikipedia-org-3485	814	3	)	)	-RRB-
en-wikipedia-org-3485	814	4	.	.	.
en-wikipedia-org-3485	815	1	"	"	``
en-wikipedia-org-3485	815	2	Cortical	cortical	JJ
en-wikipedia-org-3485	815	3	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	815	4	involvement	involvement	NN
en-wikipedia-org-3485	815	5	in	in	IN
en-wikipedia-org-3485	815	6	cocaine	cocaine	NN
en-wikipedia-org-3485	815	7	reinforcement	reinforcement	NN
en-wikipedia-org-3485	815	8	"	"	''
en-wikipedia-org-3485	815	9	.	.	.
en-wikipedia-org-3485	816	1	Science	science	NN
en-wikipedia-org-3485	816	2	.	.	.
en-wikipedia-org-3485	817	1	221	221	CD
en-wikipedia-org-3485	817	2	(	(	-LRB-
en-wikipedia-org-3485	817	3	4612	4612	CD
en-wikipedia-org-3485	817	4	)	)	-RRB-
en-wikipedia-org-3485	817	5	:	:	:
en-wikipedia-org-3485	817	6	773–775	773–775	CD
en-wikipedia-org-3485	817	7	.	.	.
en-wikipedia-org-3485	818	1	Bibcode:1983Sci	Bibcode:1983Sci	NNP
en-wikipedia-org-3485	818	2	...	...	:
en-wikipedia-org-3485	818	3	221	221	CD
en-wikipedia-org-3485	818	4	..	..	NFP
en-wikipedia-org-3485	818	5	773G.	773G.	.
en-wikipedia-org-3485	819	1	doi:10.1126	doi:10.1126	NNP
en-wikipedia-org-3485	819	2	/	/	SYM
en-wikipedia-org-3485	819	3	science.6879176	science.6879176	NNP
en-wikipedia-org-3485	819	4	.	.	.
en-wikipedia-org-3485	820	1	PMID	PMID	NNP
en-wikipedia-org-3485	820	2	 	  	_SP
en-wikipedia-org-3485	820	3	6879176	6879176	CD
en-wikipedia-org-3485	820	4	.	.	.
en-wikipedia-org-3485	821	1	^	^	NFP
en-wikipedia-org-3485	821	2	Goeders	Goeders	NNP
en-wikipedia-org-3485	821	3	N.E.	N.E.	NNP
en-wikipedia-org-3485	821	4	,	,	,
en-wikipedia-org-3485	821	5	Smith	Smith	NNP
en-wikipedia-org-3485	821	6	J.E.	J.E.	NNP
en-wikipedia-org-3485	822	1	(	(	-LRB-
en-wikipedia-org-3485	822	2	1993	1993	CD
en-wikipedia-org-3485	822	3	)	)	-RRB-
en-wikipedia-org-3485	822	4	.	.	.
en-wikipedia-org-3485	823	1	"	"	``
en-wikipedia-org-3485	823	2	Intracranial	intracranial	JJ
en-wikipedia-org-3485	823	3	cocaine	cocaine	NN
en-wikipedia-org-3485	823	4	self	self	NN
en-wikipedia-org-3485	823	5	-	-	HYPH
en-wikipedia-org-3485	823	6	administration	administration	NN
en-wikipedia-org-3485	823	7	into	into	IN
en-wikipedia-org-3485	823	8	the	the	DT
en-wikipedia-org-3485	823	9	medial	medial	NNP
en-wikipedia-org-3485	823	10	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	823	11	cortex	cortex	NNP
en-wikipedia-org-3485	823	12	increases	increase	VBZ
en-wikipedia-org-3485	823	13	dopamine	dopamine	NN
en-wikipedia-org-3485	823	14	turnover	turnover	NN
en-wikipedia-org-3485	823	15	in	in	IN
en-wikipedia-org-3485	823	16	the	the	DT
en-wikipedia-org-3485	823	17	nucleus	nucleus	NN
en-wikipedia-org-3485	823	18	accumbens	accumben	VBZ
en-wikipedia-org-3485	823	19	"	"	''
en-wikipedia-org-3485	823	20	.	.	.
en-wikipedia-org-3485	824	1	J.	J.	NNP
en-wikipedia-org-3485	824	2	Pharmacol	Pharmacol	NNP
en-wikipedia-org-3485	824	3	.	.	.
en-wikipedia-org-3485	825	1	Exp	Exp	NNP
en-wikipedia-org-3485	825	2	.	.	.
en-wikipedia-org-3485	826	1	Ther	ther	RB
en-wikipedia-org-3485	826	2	.	.	.
en-wikipedia-org-3485	827	1	265	265	CD
en-wikipedia-org-3485	827	2	(	(	-LRB-
en-wikipedia-org-3485	827	3	2	2	CD
en-wikipedia-org-3485	827	4	)	)	-RRB-
en-wikipedia-org-3485	827	5	:	:	:
en-wikipedia-org-3485	827	6	592–600	592–600	CD
en-wikipedia-org-3485	827	7	.	.	.
en-wikipedia-org-3485	828	1	PMID	PMID	NNP
en-wikipedia-org-3485	828	2	 	  	_SP
en-wikipedia-org-3485	828	3	8496810	8496810	CD
en-wikipedia-org-3485	828	4	.	.	.
en-wikipedia-org-3485	829	1	^	^	NNP
en-wikipedia-org-3485	829	2	Clarke	Clarke	NNP
en-wikipedia-org-3485	829	3	,	,	,
en-wikipedia-org-3485	829	4	Hommer	Hommer	NNP
en-wikipedia-org-3485	829	5	D.W.	D.W.	NNP
en-wikipedia-org-3485	829	6	;	;	:
en-wikipedia-org-3485	829	7	Pert	Pert	NNP
en-wikipedia-org-3485	829	8	A.	a.	NN
en-wikipedia-org-3485	829	9	;	;	:
en-wikipedia-org-3485	829	10	Skirboll	Skirboll	NNP
en-wikipedia-org-3485	829	11	L.R.	L.R.	NNP
en-wikipedia-org-3485	830	1	(	(	-LRB-
en-wikipedia-org-3485	830	2	1985	1985	CD
en-wikipedia-org-3485	830	3	)	)	-RRB-
en-wikipedia-org-3485	830	4	.	.	.
en-wikipedia-org-3485	831	1	"	"	``
en-wikipedia-org-3485	831	2	Electrophysiological	electrophysiological	JJ
en-wikipedia-org-3485	831	3	actions	action	NNS
en-wikipedia-org-3485	831	4	of	of	IN
en-wikipedia-org-3485	831	5	nicotine	nicotine	NN
en-wikipedia-org-3485	831	6	on	on	IN
en-wikipedia-org-3485	831	7	substantia	substantia	NNP
en-wikipedia-org-3485	831	8	nigra	nigra	NNP
en-wikipedia-org-3485	831	9	single	single	JJ
en-wikipedia-org-3485	831	10	units	unit	NNS
en-wikipedia-org-3485	831	11	"	"	''
en-wikipedia-org-3485	831	12	.	.	.
en-wikipedia-org-3485	832	1	Br	br	UH
en-wikipedia-org-3485	832	2	.	.	.
en-wikipedia-org-3485	833	1	J.	J.	NNP
en-wikipedia-org-3485	833	2	Pharmacol	Pharmacol	NNP
en-wikipedia-org-3485	833	3	.	.	.
en-wikipedia-org-3485	834	1	85	85	CD
en-wikipedia-org-3485	834	2	(	(	-LRB-
en-wikipedia-org-3485	834	3	4	4	CD
en-wikipedia-org-3485	834	4	)	)	-RRB-
en-wikipedia-org-3485	834	5	:	:	:
en-wikipedia-org-3485	834	6	827–835	827–835	CD
en-wikipedia-org-3485	834	7	.	.	.
en-wikipedia-org-3485	835	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-3485	835	2	/	/	SYM
en-wikipedia-org-3485	835	3	j.1476	j.1476	NNP
en-wikipedia-org-3485	835	4	-	-	HYPH
en-wikipedia-org-3485	835	5	5381.1985.tb11081.x	5381.1985.tb11081.x	CD
en-wikipedia-org-3485	835	6	.	.	.
en-wikipedia-org-3485	836	1	PMC	PMC	NNP
en-wikipedia-org-3485	836	2	 	  	_SP
en-wikipedia-org-3485	836	3	1916681	1916681	CD
en-wikipedia-org-3485	836	4	.	.	.
en-wikipedia-org-3485	837	1	PMID	PMID	NNP
en-wikipedia-org-3485	837	2	 	  	_SP
en-wikipedia-org-3485	837	3	4041681	4041681	CD
en-wikipedia-org-3485	837	4	.	.	.
en-wikipedia-org-3485	838	1	^	^	NNP
en-wikipedia-org-3485	838	2	Westfall	Westfall	NNP
en-wikipedia-org-3485	838	3	,	,	,
en-wikipedia-org-3485	838	4	Thomas	Thomas	NNP
en-wikipedia-org-3485	838	5	C.	C.	NNP
en-wikipedia-org-3485	838	6	;	;	:
en-wikipedia-org-3485	838	7	Grant	Grant	NNP
en-wikipedia-org-3485	838	8	,	,	,
en-wikipedia-org-3485	838	9	Heather	Heather	NNP
en-wikipedia-org-3485	838	10	;	;	:
en-wikipedia-org-3485	838	11	Perry	Perry	NNP
en-wikipedia-org-3485	838	12	,	,	,
en-wikipedia-org-3485	838	13	Holly	Holly	NNP
en-wikipedia-org-3485	838	14	(	(	-LRB-
en-wikipedia-org-3485	838	15	January	January	NNP
en-wikipedia-org-3485	838	16	1983	1983	CD
en-wikipedia-org-3485	838	17	)	)	-RRB-
en-wikipedia-org-3485	838	18	.	.	.
en-wikipedia-org-3485	839	1	"	"	``
en-wikipedia-org-3485	839	2	Release	Release	NNP
en-wikipedia-org-3485	839	3	of	of	IN
en-wikipedia-org-3485	839	4	dopamine	dopamine	NN
en-wikipedia-org-3485	839	5	and	and	CC
en-wikipedia-org-3485	839	6	5-hydroxytryptamine	5-hydroxytryptamine	CD
en-wikipedia-org-3485	839	7	from	from	IN
en-wikipedia-org-3485	839	8	rat	rat	NN
en-wikipedia-org-3485	839	9	striatal	striatal	JJ
en-wikipedia-org-3485	839	10	slices	slice	NNS
en-wikipedia-org-3485	839	11	following	follow	VBG
en-wikipedia-org-3485	839	12	activation	activation	NN
en-wikipedia-org-3485	839	13	of	of	IN
en-wikipedia-org-3485	839	14	nicotinic	nicotinic	JJ
en-wikipedia-org-3485	839	15	cholinergic	cholinergic	JJ
en-wikipedia-org-3485	839	16	receptors	receptor	NNS
en-wikipedia-org-3485	839	17	"	"	''
en-wikipedia-org-3485	839	18	.	.	.
en-wikipedia-org-3485	840	1	General	General	NNP
en-wikipedia-org-3485	840	2	Pharmacology	Pharmacology	NNP
en-wikipedia-org-3485	840	3	:	:	:
en-wikipedia-org-3485	840	4	The	the	DT
en-wikipedia-org-3485	840	5	Vascular	Vascular	NNP
en-wikipedia-org-3485	840	6	System	System	NNP
en-wikipedia-org-3485	840	7	.	.	.
en-wikipedia-org-3485	841	1	14	14	CD
en-wikipedia-org-3485	841	2	(	(	-LRB-
en-wikipedia-org-3485	841	3	3	3	CD
en-wikipedia-org-3485	841	4	)	)	-RRB-
en-wikipedia-org-3485	841	5	:	:	:
en-wikipedia-org-3485	841	6	321–325	321–325	CD
en-wikipedia-org-3485	841	7	.	.	.
en-wikipedia-org-3485	842	1	doi:10.1016/0306	doi:10.1016/0306	NN
en-wikipedia-org-3485	842	2	-	-	HYPH
en-wikipedia-org-3485	842	3	3623(83)90037-x	3623(83)90037-x	NNP
en-wikipedia-org-3485	842	4	.	.	.
en-wikipedia-org-3485	843	1	PMID	PMID	NNP
en-wikipedia-org-3485	843	2	 	  	_SP
en-wikipedia-org-3485	843	3	6135645	6135645	CD
en-wikipedia-org-3485	843	4	.	.	.
en-wikipedia-org-3485	844	1	^	^	NFP
en-wikipedia-org-3485	844	2	Rømer	Rømer	NNP
en-wikipedia-org-3485	844	3	Thomsen	Thomsen	NNP
en-wikipedia-org-3485	844	4	,	,	,
en-wikipedia-org-3485	844	5	K	K	NNP
en-wikipedia-org-3485	844	6	;	;	:
en-wikipedia-org-3485	844	7	Whybrow	Whybrow	NNP
en-wikipedia-org-3485	844	8	,	,	,
en-wikipedia-org-3485	844	9	PC	pc	NN
en-wikipedia-org-3485	844	10	;	;	:
en-wikipedia-org-3485	844	11	Kringelbach	Kringelbach	NNP
en-wikipedia-org-3485	844	12	,	,	,
en-wikipedia-org-3485	844	13	ML	ML	NNP
en-wikipedia-org-3485	844	14	(	(	-LRB-
en-wikipedia-org-3485	844	15	2015	2015	CD
en-wikipedia-org-3485	844	16	)	)	-RRB-
en-wikipedia-org-3485	844	17	.	.	.
en-wikipedia-org-3485	845	1	"	"	``
en-wikipedia-org-3485	845	2	Reconceptualizing	reconceptualize	VBG
en-wikipedia-org-3485	845	3	anhedonia	anhedonia	NN
en-wikipedia-org-3485	845	4	:	:	:
en-wikipedia-org-3485	845	5	novel	novel	JJ
en-wikipedia-org-3485	845	6	perspectives	perspective	VBZ
en-wikipedia-org-3485	845	7	on	on	IN
en-wikipedia-org-3485	845	8	balancing	balance	VBG
en-wikipedia-org-3485	845	9	the	the	DT
en-wikipedia-org-3485	845	10	pleasure	pleasure	NN
en-wikipedia-org-3485	845	11	networks	network	NNS
en-wikipedia-org-3485	845	12	in	in	IN
en-wikipedia-org-3485	845	13	the	the	DT
en-wikipedia-org-3485	845	14	human	human	JJ
en-wikipedia-org-3485	845	15	brain	brain	NN
en-wikipedia-org-3485	845	16	"	"	''
en-wikipedia-org-3485	845	17	.	.	.
en-wikipedia-org-3485	846	1	Frontiers	frontier	NNS
en-wikipedia-org-3485	846	2	in	in	IN
en-wikipedia-org-3485	846	3	Behavioral	Behavioral	NNP
en-wikipedia-org-3485	846	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	846	5	.	.	.
en-wikipedia-org-3485	847	1	9	9	CD
en-wikipedia-org-3485	847	2	:	:	SYM
en-wikipedia-org-3485	847	3	49	49	CD
en-wikipedia-org-3485	847	4	.	.	.
en-wikipedia-org-3485	847	5	doi:10.3389	doi:10.3389	NNP
en-wikipedia-org-3485	847	6	/	/	SYM
en-wikipedia-org-3485	847	7	fnbeh.2015.00049	fnbeh.2015.00049	ADD
en-wikipedia-org-3485	847	8	.	.	.
en-wikipedia-org-3485	848	1	PMC	PMC	NNP
en-wikipedia-org-3485	848	2	 	  	_SP
en-wikipedia-org-3485	848	3	4356228	4356228	CD
en-wikipedia-org-3485	848	4	.	.	.
en-wikipedia-org-3485	849	1	PMID	PMID	NNP
en-wikipedia-org-3485	849	2	 	  	_SP
en-wikipedia-org-3485	849	3	25814941	25814941	CD
en-wikipedia-org-3485	849	4	.	.	.
en-wikipedia-org-3485	850	1	^	^	NNP
en-wikipedia-org-3485	850	2	Thomsen	Thomsen	NNP
en-wikipedia-org-3485	850	3	,	,	,
en-wikipedia-org-3485	850	4	KR	KR	NNP
en-wikipedia-org-3485	850	5	(	(	-LRB-
en-wikipedia-org-3485	850	6	2015	2015	CD
en-wikipedia-org-3485	850	7	)	)	-RRB-
en-wikipedia-org-3485	850	8	.	.	.
en-wikipedia-org-3485	851	1	"	"	``
en-wikipedia-org-3485	851	2	Measuring	measure	VBG
en-wikipedia-org-3485	851	3	anhedonia	anhedonia	NN
en-wikipedia-org-3485	851	4	:	:	:
en-wikipedia-org-3485	851	5	impaired	impair	VBN
en-wikipedia-org-3485	851	6	ability	ability	NN
en-wikipedia-org-3485	851	7	to	to	TO
en-wikipedia-org-3485	851	8	pursue	pursue	VB
en-wikipedia-org-3485	851	9	,	,	,
en-wikipedia-org-3485	851	10	experience	experience	NN
en-wikipedia-org-3485	851	11	,	,	,
en-wikipedia-org-3485	851	12	and	and	CC
en-wikipedia-org-3485	851	13	learn	learn	VB
en-wikipedia-org-3485	851	14	about	about	IN
en-wikipedia-org-3485	851	15	reward	reward	NN
en-wikipedia-org-3485	851	16	"	"	''
en-wikipedia-org-3485	851	17	.	.	.
en-wikipedia-org-3485	852	1	Frontiers	Frontiers	NNP
en-wikipedia-org-3485	852	2	in	in	IN
en-wikipedia-org-3485	852	3	Psychology	psychology	NN
en-wikipedia-org-3485	852	4	.	.	.
en-wikipedia-org-3485	853	1	6	6	CD
en-wikipedia-org-3485	853	2	:	:	SYM
en-wikipedia-org-3485	853	3	1409	1409	CD
en-wikipedia-org-3485	853	4	.	.	.
en-wikipedia-org-3485	853	5	doi:10.3389	doi:10.3389	NNP
en-wikipedia-org-3485	853	6	/	/	SYM
en-wikipedia-org-3485	853	7	fpsyg.2015.01409	fpsyg.2015.01409	CD
en-wikipedia-org-3485	853	8	.	.	.
en-wikipedia-org-3485	854	1	PMC	PMC	NNP
en-wikipedia-org-3485	854	2	 	  	_SP
en-wikipedia-org-3485	854	3	4585007	4585007	CD
en-wikipedia-org-3485	854	4	.	.	.
en-wikipedia-org-3485	855	1	PMID	PMID	NNP
en-wikipedia-org-3485	855	2	 	  	_SP
en-wikipedia-org-3485	855	3	26441781	26441781	CD
en-wikipedia-org-3485	855	4	.	.	.
en-wikipedia-org-3485	856	1	^	^	NNP
en-wikipedia-org-3485	856	2	Olney	Olney	NNP
en-wikipedia-org-3485	856	3	,	,	,
en-wikipedia-org-3485	856	4	JJ	JJ	NNP
en-wikipedia-org-3485	856	5	;	;	:
en-wikipedia-org-3485	856	6	Warlow	Warlow	NNP
en-wikipedia-org-3485	856	7	,	,	,
en-wikipedia-org-3485	856	8	SM	SM	NNP
en-wikipedia-org-3485	856	9	;	;	:
en-wikipedia-org-3485	856	10	Naffziger	Naffziger	NNP
en-wikipedia-org-3485	856	11	,	,	,
en-wikipedia-org-3485	856	12	EE	EE	NNP
en-wikipedia-org-3485	856	13	;	;	:
en-wikipedia-org-3485	856	14	Berridge	Berridge	NNP
en-wikipedia-org-3485	856	15	,	,	,
en-wikipedia-org-3485	856	16	KC	KC	NNP
en-wikipedia-org-3485	856	17	(	(	-LRB-
en-wikipedia-org-3485	856	18	August	August	NNP
en-wikipedia-org-3485	856	19	2018	2018	CD
en-wikipedia-org-3485	856	20	)	)	-RRB-
en-wikipedia-org-3485	856	21	.	.	.
en-wikipedia-org-3485	857	1	"	"	``
en-wikipedia-org-3485	857	2	Current	current	JJ
en-wikipedia-org-3485	857	3	perspectives	perspective	NNS
en-wikipedia-org-3485	857	4	on	on	IN
en-wikipedia-org-3485	857	5	incentive	incentive	NN
en-wikipedia-org-3485	857	6	salience	salience	NN
en-wikipedia-org-3485	857	7	and	and	CC
en-wikipedia-org-3485	857	8	applications	application	NNS
en-wikipedia-org-3485	857	9	to	to	IN
en-wikipedia-org-3485	857	10	clinical	clinical	JJ
en-wikipedia-org-3485	857	11	disorders	disorder	NNS
en-wikipedia-org-3485	857	12	"	"	''
en-wikipedia-org-3485	857	13	.	.	.
en-wikipedia-org-3485	858	1	Current	current	JJ
en-wikipedia-org-3485	858	2	Opinion	opinion	NN
en-wikipedia-org-3485	858	3	in	in	IN
en-wikipedia-org-3485	858	4	Behavioral	Behavioral	NNP
en-wikipedia-org-3485	858	5	Sciences	Sciences	NNPS
en-wikipedia-org-3485	858	6	.	.	.
en-wikipedia-org-3485	859	1	22	22	CD
en-wikipedia-org-3485	859	2	:	:	:
en-wikipedia-org-3485	859	3	59–69	59–69	CD
en-wikipedia-org-3485	859	4	.	.	.
en-wikipedia-org-3485	860	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	860	2	/	/	SYM
en-wikipedia-org-3485	860	3	j.cobeha.2018.01.007	j.cobeha.2018.01.007	CD
en-wikipedia-org-3485	860	4	.	.	.
en-wikipedia-org-3485	861	1	PMC	PMC	NNP
en-wikipedia-org-3485	861	2	 	  	_SP
en-wikipedia-org-3485	861	3	5831552	5831552	CD
en-wikipedia-org-3485	861	4	.	.	.
en-wikipedia-org-3485	862	1	PMID	PMID	NNP
en-wikipedia-org-3485	862	2	 	  	_SP
en-wikipedia-org-3485	862	3	29503841	29503841	CD
en-wikipedia-org-3485	862	4	.	.	.
en-wikipedia-org-3485	863	1	^	^	NNP
en-wikipedia-org-3485	863	2	Preda	Preda	NNP
en-wikipedia-org-3485	863	3	,	,	,
en-wikipedia-org-3485	863	4	Adrian	Adrian	NNP
en-wikipedia-org-3485	863	5	(	(	-LRB-
en-wikipedia-org-3485	863	6	2014	2014	CD
en-wikipedia-org-3485	863	7	)	)	-RRB-
en-wikipedia-org-3485	863	8	.	.	.
en-wikipedia-org-3485	864	1	"	"	``
en-wikipedia-org-3485	864	2	Brain	Brain	NNP
en-wikipedia-org-3485	864	3	Imaging	Imaging	NNP
en-wikipedia-org-3485	864	4	Correlates	Correlates	NNPS
en-wikipedia-org-3485	864	5	of	of	IN
en-wikipedia-org-3485	864	6	Anhedonia	Anhedonia	NNP
en-wikipedia-org-3485	864	7	"	"	''
en-wikipedia-org-3485	864	8	.	.	.
en-wikipedia-org-3485	865	1	In	in	IN
en-wikipedia-org-3485	865	2	Ritsner	Ritsner	NNP
en-wikipedia-org-3485	865	3	,	,	,
en-wikipedia-org-3485	865	4	Michael	Michael	NNP
en-wikipedia-org-3485	865	5	(	(	-LRB-
en-wikipedia-org-3485	865	6	ed	ed	NNP
en-wikipedia-org-3485	865	7	.	.	.
en-wikipedia-org-3485	865	8	)	)	-RRB-
en-wikipedia-org-3485	865	9	.	.	.
en-wikipedia-org-3485	866	1	Anhedonia	Anhedonia	NNP
en-wikipedia-org-3485	866	2	 	  	_SP
en-wikipedia-org-3485	866	3	:	:	:
en-wikipedia-org-3485	866	4	a	a	DT
en-wikipedia-org-3485	866	5	comprehensive	comprehensive	JJ
en-wikipedia-org-3485	866	6	handbook	handbook	NN
en-wikipedia-org-3485	866	7	.	.	.
en-wikipedia-org-3485	867	1	Dordrecht	Dordrecht	NNP
en-wikipedia-org-3485	867	2	:	:	:
en-wikipedia-org-3485	867	3	Springer	Springer	NNP
en-wikipedia-org-3485	867	4	Netherlands	Netherlands	NNP
en-wikipedia-org-3485	867	5	.	.	.
en-wikipedia-org-3485	868	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	868	2	 	  	_SP
en-wikipedia-org-3485	868	3	978	978	CD
en-wikipedia-org-3485	868	4	-	-	HYPH
en-wikipedia-org-3485	868	5	94	94	CD
en-wikipedia-org-3485	868	6	-	-	HYPH
en-wikipedia-org-3485	868	7	017	017	CD
en-wikipedia-org-3485	868	8	-	-	HYPH
en-wikipedia-org-3485	868	9	8590	8590	CD
en-wikipedia-org-3485	868	10	-	-	SYM
en-wikipedia-org-3485	868	11	7	7	CD
en-wikipedia-org-3485	868	12	.	.	.
en-wikipedia-org-3485	869	1	^	^	NNP
en-wikipedia-org-3485	869	2	Zhang	Zhang	NNP
en-wikipedia-org-3485	869	3	,	,	,
en-wikipedia-org-3485	869	4	B	B	NNP
en-wikipedia-org-3485	869	5	;	;	:
en-wikipedia-org-3485	869	6	Lin	Lin	NNP
en-wikipedia-org-3485	869	7	,	,	,
en-wikipedia-org-3485	869	8	P	P	NNP
en-wikipedia-org-3485	869	9	;	;	:
en-wikipedia-org-3485	869	10	Shi	Shi	NNP
en-wikipedia-org-3485	869	11	,	,	,
en-wikipedia-org-3485	869	12	H	H	NNP
en-wikipedia-org-3485	869	13	;	;	:
en-wikipedia-org-3485	869	14	Öngür	Öngür	NNP
en-wikipedia-org-3485	869	15	,	,	,
en-wikipedia-org-3485	869	16	D	D	NNP
en-wikipedia-org-3485	869	17	;	;	:
en-wikipedia-org-3485	869	18	Auerbach	Auerbach	NNP
en-wikipedia-org-3485	869	19	,	,	,
en-wikipedia-org-3485	869	20	RP	RP	NNP
en-wikipedia-org-3485	869	21	;	;	:
en-wikipedia-org-3485	869	22	Wang	Wang	NNP
en-wikipedia-org-3485	869	23	,	,	,
en-wikipedia-org-3485	869	24	X	X	NNP
en-wikipedia-org-3485	869	25	;	;	:
en-wikipedia-org-3485	869	26	Yao	Yao	NNP
en-wikipedia-org-3485	869	27	,	,	,
en-wikipedia-org-3485	869	28	S	S	NNP
en-wikipedia-org-3485	869	29	;	;	:
en-wikipedia-org-3485	869	30	Wang	Wang	NNP
en-wikipedia-org-3485	869	31	,	,	,
en-wikipedia-org-3485	869	32	X	X	NNP
en-wikipedia-org-3485	869	33	(	(	-LRB-
en-wikipedia-org-3485	869	34	September	September	NNP
en-wikipedia-org-3485	869	35	2016	2016	CD
en-wikipedia-org-3485	869	36	)	)	-RRB-
en-wikipedia-org-3485	869	37	.	.	.
en-wikipedia-org-3485	870	1	"	"	``
en-wikipedia-org-3485	870	2	Mapping	map	VBG
en-wikipedia-org-3485	870	3	anhedonia	anhedonia	RB
en-wikipedia-org-3485	870	4	-	-	HYPH
en-wikipedia-org-3485	870	5	specific	specific	JJ
en-wikipedia-org-3485	870	6	dysfunction	dysfunction	NN
en-wikipedia-org-3485	870	7	in	in	IN
en-wikipedia-org-3485	870	8	a	a	DT
en-wikipedia-org-3485	870	9	transdiagnostic	transdiagnostic	JJ
en-wikipedia-org-3485	870	10	approach	approach	NN
en-wikipedia-org-3485	870	11	:	:	:
en-wikipedia-org-3485	870	12	an	an	DT
en-wikipedia-org-3485	870	13	ALE	ALE	NNP
en-wikipedia-org-3485	870	14	meta	meta	JJ
en-wikipedia-org-3485	870	15	-	-	HYPH
en-wikipedia-org-3485	870	16	analysis	analysis	NN
en-wikipedia-org-3485	870	17	"	"	''
en-wikipedia-org-3485	870	18	.	.	.
en-wikipedia-org-3485	871	1	Brain	Brain	NNP
en-wikipedia-org-3485	871	2	Imaging	Imaging	NNP
en-wikipedia-org-3485	871	3	and	and	CC
en-wikipedia-org-3485	871	4	Behavior	Behavior	NNP
en-wikipedia-org-3485	871	5	.	.	.
en-wikipedia-org-3485	872	1	10	10	CD
en-wikipedia-org-3485	872	2	(	(	-LRB-
en-wikipedia-org-3485	872	3	3	3	CD
en-wikipedia-org-3485	872	4	)	)	-RRB-
en-wikipedia-org-3485	872	5	:	:	:
en-wikipedia-org-3485	872	6	920–39	920–39	CD
en-wikipedia-org-3485	872	7	.	.	.
en-wikipedia-org-3485	873	1	doi:10.1007	doi:10.1007	NNP
en-wikipedia-org-3485	873	2	/	/	SYM
en-wikipedia-org-3485	873	3	s11682	s11682	JJ
en-wikipedia-org-3485	873	4	-	-	HYPH
en-wikipedia-org-3485	873	5	015	015	CD
en-wikipedia-org-3485	873	6	-	-	HYPH
en-wikipedia-org-3485	873	7	9457	9457	CD
en-wikipedia-org-3485	873	8	-	-	HYPH
en-wikipedia-org-3485	873	9	6	6	CD
en-wikipedia-org-3485	873	10	.	.	.
en-wikipedia-org-3485	874	1	PMC	PMC	NNP
en-wikipedia-org-3485	874	2	 	  	_SP
en-wikipedia-org-3485	874	3	4838562	4838562	CD
en-wikipedia-org-3485	874	4	.	.	.
en-wikipedia-org-3485	875	1	PMID	PMID	NNP
en-wikipedia-org-3485	875	2	 	  	_SP
en-wikipedia-org-3485	875	3	26487590	26487590	CD
en-wikipedia-org-3485	875	4	.	.	.
en-wikipedia-org-3485	876	1	^	^	NNP
en-wikipedia-org-3485	876	2	Treadway	Treadway	NNP
en-wikipedia-org-3485	876	3	,	,	,
en-wikipedia-org-3485	876	4	Michael	Michael	NNP
en-wikipedia-org-3485	876	5	,	,	,
en-wikipedia-org-3485	876	6	T.	T.	NNP
en-wikipedia-org-3485	876	7	(	(	-LRB-
en-wikipedia-org-3485	876	8	2016	2016	CD
en-wikipedia-org-3485	876	9	)	)	-RRB-
en-wikipedia-org-3485	876	10	.	.	.
en-wikipedia-org-3485	877	1	"	"	``
en-wikipedia-org-3485	877	2	The	the	DT
en-wikipedia-org-3485	877	3	Neurobiology	Neurobiology	NNP
en-wikipedia-org-3485	877	4	of	of	IN
en-wikipedia-org-3485	877	5	Motivational	Motivational	NNP
en-wikipedia-org-3485	877	6	Deficits	Deficits	NNPS
en-wikipedia-org-3485	877	7	in	in	IN
en-wikipedia-org-3485	877	8	Depression	Depression	NNP
en-wikipedia-org-3485	877	9	—	—	:
en-wikipedia-org-3485	877	10	An	an	DT
en-wikipedia-org-3485	877	11	Update	update	NN
en-wikipedia-org-3485	877	12	on	on	IN
en-wikipedia-org-3485	877	13	Candidate	Candidate	NNP
en-wikipedia-org-3485	877	14	Pathomechanisms	Pathomechanisms	NNP
en-wikipedia-org-3485	877	15	"	"	''
en-wikipedia-org-3485	877	16	.	.	.
en-wikipedia-org-3485	878	1	In	in	IN
en-wikipedia-org-3485	878	2	Simpson	Simpson	NNP
en-wikipedia-org-3485	878	3	,	,	,
en-wikipedia-org-3485	878	4	Eleanor	Eleanor	NNP
en-wikipedia-org-3485	878	5	H.	H.	NNP
en-wikipedia-org-3485	878	6	;	;	:
en-wikipedia-org-3485	878	7	Balsam	Balsam	NNP
en-wikipedia-org-3485	878	8	,	,	,
en-wikipedia-org-3485	878	9	Peter	Peter	NNP
en-wikipedia-org-3485	878	10	D.	D.	NNP
en-wikipedia-org-3485	879	1	(	(	-LRB-
en-wikipedia-org-3485	879	2	eds	eds	NNP
en-wikipedia-org-3485	879	3	.	.	.
en-wikipedia-org-3485	879	4	)	)	-RRB-
en-wikipedia-org-3485	879	5	.	.	.
en-wikipedia-org-3485	880	1	Behavioral	behavioral	JJ
en-wikipedia-org-3485	880	2	Neuroscience	neuroscience	NN
en-wikipedia-org-3485	880	3	of	of	IN
en-wikipedia-org-3485	880	4	Motivation	Motivation	NNP
en-wikipedia-org-3485	880	5	(	(	-LRB-
en-wikipedia-org-3485	880	6	Current	Current	NNP
en-wikipedia-org-3485	880	7	Topics	Topics	NNPS
en-wikipedia-org-3485	880	8	in	in	IN
en-wikipedia-org-3485	880	9	Behavioral	Behavioral	NNP
en-wikipedia-org-3485	880	10	Neurosciences	Neurosciences	NNPS
en-wikipedia-org-3485	880	11	)	)	-RRB-
en-wikipedia-org-3485	880	12	(	(	-LRB-
en-wikipedia-org-3485	880	13	1st	1st	NNP
en-wikipedia-org-3485	880	14	ed	ed	NNP
en-wikipedia-org-3485	880	15	.	.	.
en-wikipedia-org-3485	880	16	)	)	-RRB-
en-wikipedia-org-3485	880	17	.	.	.
en-wikipedia-org-3485	881	1	Switzerland	Switzerland	NNP
en-wikipedia-org-3485	881	2	:	:	:
en-wikipedia-org-3485	881	3	Springer	Springer	NNP
en-wikipedia-org-3485	881	4	International	International	NNP
en-wikipedia-org-3485	881	5	Publishing	Publishing	NNP
en-wikipedia-org-3485	881	6	.	.	.
en-wikipedia-org-3485	882	1	p.	p.	NN
en-wikipedia-org-3485	882	2	 	  	_SP
en-wikipedia-org-3485	882	3	343	343	CD
en-wikipedia-org-3485	882	4	.	.	.
en-wikipedia-org-3485	883	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	883	2	 	  	_SP
en-wikipedia-org-3485	883	3	978	978	CD
en-wikipedia-org-3485	883	4	-	-	HYPH
en-wikipedia-org-3485	883	5	3	3	CD
en-wikipedia-org-3485	883	6	-	-	HYPH
en-wikipedia-org-3485	883	7	319	319	CD
en-wikipedia-org-3485	883	8	-	-	HYPH
en-wikipedia-org-3485	883	9	26933	26933	CD
en-wikipedia-org-3485	883	10	-	-	SYM
en-wikipedia-org-3485	883	11	7	7	CD
en-wikipedia-org-3485	883	12	.	.	.
en-wikipedia-org-3485	884	1	In	in	IN
en-wikipedia-org-3485	884	2	a	a	DT
en-wikipedia-org-3485	884	3	relatively	relatively	RB
en-wikipedia-org-3485	884	4	recent	recent	JJ
en-wikipedia-org-3485	884	5	literature	literature	NN
en-wikipedia-org-3485	884	6	,	,	,
en-wikipedia-org-3485	884	7	studies	study	NNS
en-wikipedia-org-3485	884	8	of	of	IN
en-wikipedia-org-3485	884	9	motivation	motivation	NN
en-wikipedia-org-3485	884	10	and	and	CC
en-wikipedia-org-3485	884	11	reinforcement	reinforcement	NN
en-wikipedia-org-3485	884	12	in	in	IN
en-wikipedia-org-3485	884	13	depression	depression	NN
en-wikipedia-org-3485	884	14	have	have	VBP
en-wikipedia-org-3485	884	15	been	be	VBN
en-wikipedia-org-3485	884	16	largely	largely	RB
en-wikipedia-org-3485	884	17	consistent	consistent	JJ
en-wikipedia-org-3485	884	18	in	in	IN
en-wikipedia-org-3485	884	19	detecting	detect	VBG
en-wikipedia-org-3485	884	20	differences	difference	NNS
en-wikipedia-org-3485	884	21	as	as	IN
en-wikipedia-org-3485	884	22	compared	compare	VBN
en-wikipedia-org-3485	884	23	to	to	IN
en-wikipedia-org-3485	884	24	healthy	healthy	JJ
en-wikipedia-org-3485	884	25	controls	control	NNS
en-wikipedia-org-3485	884	26	(	(	-LRB-
en-wikipedia-org-3485	884	27	Whitton	Whitton	NNP
en-wikipedia-org-3485	884	28	et	et	NNP
en-wikipedia-org-3485	884	29	al	al	NNP
en-wikipedia-org-3485	884	30	.	.	.
en-wikipedia-org-3485	885	1	2015	2015	CD
en-wikipedia-org-3485	885	2	)	)	-RRB-
en-wikipedia-org-3485	885	3	.	.	.
en-wikipedia-org-3485	886	1	In	in	IN
en-wikipedia-org-3485	886	2	several	several	JJ
en-wikipedia-org-3485	886	3	studies	study	NNS
en-wikipedia-org-3485	886	4	using	use	VBG
en-wikipedia-org-3485	886	5	the	the	DT
en-wikipedia-org-3485	886	6	effort	effort	NN
en-wikipedia-org-3485	886	7	expenditure	expenditure	NN
en-wikipedia-org-3485	886	8	for	for	IN
en-wikipedia-org-3485	886	9	reward	reward	NN
en-wikipedia-org-3485	886	10	task	task	NN
en-wikipedia-org-3485	886	11	(	(	-LRB-
en-wikipedia-org-3485	886	12	EEfRT	eefrt	NN
en-wikipedia-org-3485	886	13	)	)	-RRB-
en-wikipedia-org-3485	886	14	,	,	,
en-wikipedia-org-3485	886	15	patients	patient	NNS
en-wikipedia-org-3485	886	16	with	with	IN
en-wikipedia-org-3485	886	17	MDD	MDD	NNP
en-wikipedia-org-3485	886	18	expended	expend	VBD
en-wikipedia-org-3485	886	19	less	less	JJR
en-wikipedia-org-3485	886	20	effort	effort	NN
en-wikipedia-org-3485	886	21	for	for	IN
en-wikipedia-org-3485	886	22	rewards	reward	NNS
en-wikipedia-org-3485	886	23	when	when	WRB
en-wikipedia-org-3485	886	24	compared	compare	VBN
en-wikipedia-org-3485	886	25	with	with	IN
en-wikipedia-org-3485	886	26	controls	control	NNS
en-wikipedia-org-3485	886	27	(	(	-LRB-
en-wikipedia-org-3485	886	28	Treadway	Treadway	NNP
en-wikipedia-org-3485	886	29	et	et	FW
en-wikipedia-org-3485	886	30	al	al	NNP
en-wikipedia-org-3485	886	31	.	.	.
en-wikipedia-org-3485	887	1	2012	2012	CD
en-wikipedia-org-3485	887	2	;	;	:
en-wikipedia-org-3485	887	3	Yang	Yang	NNP
en-wikipedia-org-3485	887	4	et	et	FW
en-wikipedia-org-3485	887	5	al	al	NNP
en-wikipedia-org-3485	887	6	.	.	.
en-wikipedia-org-3485	888	1	2014	2014	CD
en-wikipedia-org-3485	888	2	)	)	-RRB-
en-wikipedia-org-3485	888	3	^	^	.
en-wikipedia-org-3485	888	4	Salamone	Salamone	NNP
en-wikipedia-org-3485	888	5	,	,	,
en-wikipedia-org-3485	888	6	JD	JD	NNP
en-wikipedia-org-3485	888	7	;	;	:
en-wikipedia-org-3485	888	8	Yohn	Yohn	NNP
en-wikipedia-org-3485	888	9	,	,	,
en-wikipedia-org-3485	888	10	SE	SE	NNP
en-wikipedia-org-3485	888	11	;	;	:
en-wikipedia-org-3485	888	12	López	López	NNP
en-wikipedia-org-3485	888	13	-	-	HYPH
en-wikipedia-org-3485	888	14	Cruz	Cruz	NNP
en-wikipedia-org-3485	888	15	,	,	,
en-wikipedia-org-3485	888	16	L	L	NNP
en-wikipedia-org-3485	888	17	;	;	:
en-wikipedia-org-3485	888	18	San	San	NNP
en-wikipedia-org-3485	888	19	Miguel	Miguel	NNP
en-wikipedia-org-3485	888	20	,	,	,
en-wikipedia-org-3485	888	21	N	N	NNP
en-wikipedia-org-3485	888	22	;	;	:
en-wikipedia-org-3485	888	23	Correa	Correa	NNP
en-wikipedia-org-3485	888	24	,	,	,
en-wikipedia-org-3485	888	25	M	M	NNP
en-wikipedia-org-3485	888	26	(	(	-LRB-
en-wikipedia-org-3485	888	27	May	May	NNP
en-wikipedia-org-3485	888	28	2016	2016	CD
en-wikipedia-org-3485	888	29	)	)	-RRB-
en-wikipedia-org-3485	888	30	.	.	.
en-wikipedia-org-3485	889	1	"	"	``
en-wikipedia-org-3485	889	2	Activational	activational	JJ
en-wikipedia-org-3485	889	3	and	and	CC
en-wikipedia-org-3485	889	4	effort	effort	NN
en-wikipedia-org-3485	889	5	-	-	HYPH
en-wikipedia-org-3485	889	6	related	relate	VBN
en-wikipedia-org-3485	889	7	aspects	aspect	NNS
en-wikipedia-org-3485	889	8	of	of	IN
en-wikipedia-org-3485	889	9	motivation	motivation	NN
en-wikipedia-org-3485	889	10	:	:	:
en-wikipedia-org-3485	889	11	neural	neural	JJ
en-wikipedia-org-3485	889	12	mechanisms	mechanism	NNS
en-wikipedia-org-3485	889	13	and	and	CC
en-wikipedia-org-3485	889	14	implications	implication	NNS
en-wikipedia-org-3485	889	15	for	for	IN
en-wikipedia-org-3485	889	16	psychopathology	psychopathology	NN
en-wikipedia-org-3485	889	17	"	"	''
en-wikipedia-org-3485	889	18	.	.	.
en-wikipedia-org-3485	890	1	Brain	brain	NN
en-wikipedia-org-3485	890	2	:	:	:
en-wikipedia-org-3485	890	3	A	a	DT
en-wikipedia-org-3485	890	4	Journal	Journal	NNP
en-wikipedia-org-3485	890	5	of	of	IN
en-wikipedia-org-3485	890	6	Neurology	Neurology	NNP
en-wikipedia-org-3485	890	7	.	.	.
en-wikipedia-org-3485	891	1	139	139	CD
en-wikipedia-org-3485	891	2	(	(	-LRB-
en-wikipedia-org-3485	891	3	Pt	Pt	NNP
en-wikipedia-org-3485	891	4	5	5	CD
en-wikipedia-org-3485	891	5	)	)	-RRB-
en-wikipedia-org-3485	891	6	:	:	:
en-wikipedia-org-3485	891	7	1325–47	1325–47	LS
en-wikipedia-org-3485	891	8	.	.	.
en-wikipedia-org-3485	892	1	doi:10.1093	doi:10.1093	NNP
en-wikipedia-org-3485	892	2	/	/	SYM
en-wikipedia-org-3485	892	3	brain	brain	NNP
en-wikipedia-org-3485	892	4	/	/	SYM
en-wikipedia-org-3485	892	5	aww050	aww050	CD
en-wikipedia-org-3485	892	6	.	.	.
en-wikipedia-org-3485	893	1	PMC	PMC	NNP
en-wikipedia-org-3485	893	2	 	  	_SP
en-wikipedia-org-3485	893	3	5839596	5839596	CD
en-wikipedia-org-3485	893	4	.	.	.
en-wikipedia-org-3485	894	1	PMID	PMID	NNP
en-wikipedia-org-3485	894	2	 	  	_SP
en-wikipedia-org-3485	894	3	27189581	27189581	CD
en-wikipedia-org-3485	894	4	.	.	.
en-wikipedia-org-3485	895	1	^	^	NNP
en-wikipedia-org-3485	895	2	Russo	Russo	NNP
en-wikipedia-org-3485	895	3	,	,	,
en-wikipedia-org-3485	895	4	SJ	SJ	NNP
en-wikipedia-org-3485	895	5	;	;	:
en-wikipedia-org-3485	895	6	Nestler	Nestler	NNP
en-wikipedia-org-3485	895	7	,	,	,
en-wikipedia-org-3485	895	8	EJ	EJ	NNP
en-wikipedia-org-3485	895	9	(	(	-LRB-
en-wikipedia-org-3485	895	10	September	September	NNP
en-wikipedia-org-3485	895	11	2013	2013	CD
en-wikipedia-org-3485	895	12	)	)	-RRB-
en-wikipedia-org-3485	895	13	.	.	.
en-wikipedia-org-3485	896	1	"	"	``
en-wikipedia-org-3485	896	2	The	the	DT
en-wikipedia-org-3485	896	3	brain	brain	NN
en-wikipedia-org-3485	896	4	reward	reward	NN
en-wikipedia-org-3485	896	5	circuitry	circuitry	NN
en-wikipedia-org-3485	896	6	in	in	IN
en-wikipedia-org-3485	896	7	mood	mood	NN
en-wikipedia-org-3485	896	8	disorders	disorder	NNS
en-wikipedia-org-3485	896	9	"	"	''
en-wikipedia-org-3485	896	10	.	.	.
en-wikipedia-org-3485	897	1	Nature	Nature	NNP
en-wikipedia-org-3485	897	2	Reviews	Reviews	NNPS
en-wikipedia-org-3485	897	3	.	.	.
en-wikipedia-org-3485	898	1	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	898	2	.	.	.
en-wikipedia-org-3485	899	1	14	14	CD
en-wikipedia-org-3485	899	2	(	(	-LRB-
en-wikipedia-org-3485	899	3	9	9	CD
en-wikipedia-org-3485	899	4	)	)	-RRB-
en-wikipedia-org-3485	899	5	:	:	:
en-wikipedia-org-3485	899	6	609–25	609–25	CD
en-wikipedia-org-3485	899	7	.	.	.
en-wikipedia-org-3485	900	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-3485	900	2	/	/	SYM
en-wikipedia-org-3485	900	3	nrn3381	nrn3381	NNP
en-wikipedia-org-3485	900	4	.	.	.
en-wikipedia-org-3485	901	1	PMC	PMC	NNP
en-wikipedia-org-3485	901	2	 	  	_SP
en-wikipedia-org-3485	901	3	3867253	3867253	CD
en-wikipedia-org-3485	901	4	.	.	.
en-wikipedia-org-3485	902	1	PMID	PMID	NNP
en-wikipedia-org-3485	902	2	 	  	_SP
en-wikipedia-org-3485	902	3	23942470	23942470	CD
en-wikipedia-org-3485	902	4	.	.	.
en-wikipedia-org-3485	903	1	^	^	NNP
en-wikipedia-org-3485	903	2	Treadway	Treadway	NNP
en-wikipedia-org-3485	903	3	,	,	,
en-wikipedia-org-3485	903	4	MT	MT	NNP
en-wikipedia-org-3485	903	5	;	;	:
en-wikipedia-org-3485	903	6	Zald	Zald	NNP
en-wikipedia-org-3485	903	7	,	,	,
en-wikipedia-org-3485	903	8	DH	DH	NNP
en-wikipedia-org-3485	903	9	(	(	-LRB-
en-wikipedia-org-3485	903	10	January	January	NNP
en-wikipedia-org-3485	903	11	2011	2011	CD
en-wikipedia-org-3485	903	12	)	)	-RRB-
en-wikipedia-org-3485	903	13	.	.	.
en-wikipedia-org-3485	904	1	"	"	``
en-wikipedia-org-3485	904	2	Reconsidering	reconsider	VBG
en-wikipedia-org-3485	904	3	anhedonia	anhedonia	NN
en-wikipedia-org-3485	904	4	in	in	IN
en-wikipedia-org-3485	904	5	depression	depression	NN
en-wikipedia-org-3485	904	6	:	:	:
en-wikipedia-org-3485	904	7	lessons	lesson	NNS
en-wikipedia-org-3485	904	8	from	from	IN
en-wikipedia-org-3485	904	9	translational	translational	JJ
en-wikipedia-org-3485	904	10	neuroscience	neuroscience	NN
en-wikipedia-org-3485	904	11	"	"	''
en-wikipedia-org-3485	904	12	.	.	.
en-wikipedia-org-3485	905	1	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	905	2	and	and	CC
en-wikipedia-org-3485	905	3	Biobehavioral	Biobehavioral	NNP
en-wikipedia-org-3485	905	4	Reviews	Reviews	NNPS
en-wikipedia-org-3485	905	5	.	.	.
en-wikipedia-org-3485	906	1	35	35	CD
en-wikipedia-org-3485	906	2	(	(	-LRB-
en-wikipedia-org-3485	906	3	3	3	CD
en-wikipedia-org-3485	906	4	)	)	-RRB-
en-wikipedia-org-3485	906	5	:	:	:
en-wikipedia-org-3485	906	6	537–55	537–55	CD
en-wikipedia-org-3485	906	7	.	.	.
en-wikipedia-org-3485	907	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	907	2	/	/	SYM
en-wikipedia-org-3485	907	3	j.neubiorev.2010.06.006	j.neubiorev.2010.06.006	NNP
en-wikipedia-org-3485	907	4	.	.	.
en-wikipedia-org-3485	908	1	PMC	PMC	NNP
en-wikipedia-org-3485	908	2	 	  	_SP
en-wikipedia-org-3485	908	3	3005986	3005986	CD
en-wikipedia-org-3485	908	4	.	.	.
en-wikipedia-org-3485	909	1	PMID	PMID	NNP
en-wikipedia-org-3485	909	2	 	  	_SP
en-wikipedia-org-3485	909	3	20603146	20603146	CD
en-wikipedia-org-3485	909	4	.	.	.
en-wikipedia-org-3485	910	1	^	^	NNP
en-wikipedia-org-3485	910	2	Walsh	Walsh	NNP
en-wikipedia-org-3485	910	3	,	,	,
en-wikipedia-org-3485	910	4	JJ	JJ	NNP
en-wikipedia-org-3485	910	5	;	;	:
en-wikipedia-org-3485	910	6	Han	Han	NNP
en-wikipedia-org-3485	910	7	,	,	,
en-wikipedia-org-3485	910	8	MH	MH	NNP
en-wikipedia-org-3485	910	9	(	(	-LRB-
en-wikipedia-org-3485	910	10	12	12	CD
en-wikipedia-org-3485	910	11	December	December	NNP
en-wikipedia-org-3485	910	12	2014	2014	CD
en-wikipedia-org-3485	910	13	)	)	-RRB-
en-wikipedia-org-3485	910	14	.	.	.
en-wikipedia-org-3485	911	1	"	"	``
en-wikipedia-org-3485	911	2	The	the	DT
en-wikipedia-org-3485	911	3	heterogeneity	heterogeneity	NN
en-wikipedia-org-3485	911	4	of	of	IN
en-wikipedia-org-3485	911	5	ventral	ventral	JJ
en-wikipedia-org-3485	911	6	tegmental	tegmental	JJ
en-wikipedia-org-3485	911	7	area	area	NN
en-wikipedia-org-3485	911	8	neurons	neuron	NNS
en-wikipedia-org-3485	911	9	:	:	:
en-wikipedia-org-3485	911	10	Projection	projection	NN
en-wikipedia-org-3485	911	11	functions	function	NNS
en-wikipedia-org-3485	911	12	in	in	IN
en-wikipedia-org-3485	911	13	a	a	DT
en-wikipedia-org-3485	911	14	mood	mood	NN
en-wikipedia-org-3485	911	15	-	-	HYPH
en-wikipedia-org-3485	911	16	related	relate	VBN
en-wikipedia-org-3485	911	17	context	context	NN
en-wikipedia-org-3485	911	18	"	"	''
en-wikipedia-org-3485	911	19	.	.	.
en-wikipedia-org-3485	912	1	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	912	2	.	.	.
en-wikipedia-org-3485	913	1	282	282	CD
en-wikipedia-org-3485	913	2	:	:	SYM
en-wikipedia-org-3485	913	3	101–8	101–8	CD
en-wikipedia-org-3485	913	4	.	.	.
en-wikipedia-org-3485	914	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	914	2	/	/	SYM
en-wikipedia-org-3485	914	3	j.neuroscience.2014.06.006	j.neuroscience.2014.06.006	CD
en-wikipedia-org-3485	914	4	.	.	.
en-wikipedia-org-3485	915	1	PMC	PMC	NNP
en-wikipedia-org-3485	915	2	 	  	_SP
en-wikipedia-org-3485	915	3	4339667	4339667	CD
en-wikipedia-org-3485	915	4	.	.	.
en-wikipedia-org-3485	916	1	PMID	PMID	NNP
en-wikipedia-org-3485	916	2	 	  	_SP
en-wikipedia-org-3485	916	3	24931766	24931766	CD
en-wikipedia-org-3485	916	4	.	.	.
en-wikipedia-org-3485	917	1	^	^	NNP
en-wikipedia-org-3485	917	2	Lammel	Lammel	NNP
en-wikipedia-org-3485	917	3	,	,	,
en-wikipedia-org-3485	917	4	S	S	NNP
en-wikipedia-org-3485	917	5	;	;	:
en-wikipedia-org-3485	917	6	Lim	Lim	NNP
en-wikipedia-org-3485	917	7	,	,	,
en-wikipedia-org-3485	917	8	BK	BK	NNP
en-wikipedia-org-3485	917	9	;	;	:
en-wikipedia-org-3485	917	10	Malenka	Malenka	NNP
en-wikipedia-org-3485	917	11	,	,	,
en-wikipedia-org-3485	917	12	RC	RC	NNP
en-wikipedia-org-3485	917	13	(	(	-LRB-
en-wikipedia-org-3485	917	14	January	January	NNP
en-wikipedia-org-3485	917	15	2014	2014	CD
en-wikipedia-org-3485	917	16	)	)	-RRB-
en-wikipedia-org-3485	917	17	.	.	.
en-wikipedia-org-3485	918	1	"	"	``
en-wikipedia-org-3485	918	2	Reward	reward	NN
en-wikipedia-org-3485	918	3	and	and	CC
en-wikipedia-org-3485	918	4	aversion	aversion	NN
en-wikipedia-org-3485	918	5	in	in	IN
en-wikipedia-org-3485	918	6	a	a	DT
en-wikipedia-org-3485	918	7	heterogeneous	heterogeneous	JJ
en-wikipedia-org-3485	918	8	midbrain	midbrain	NN
en-wikipedia-org-3485	918	9	dopamine	dopamine	NN
en-wikipedia-org-3485	918	10	system	system	NN
en-wikipedia-org-3485	918	11	"	"	''
en-wikipedia-org-3485	918	12	.	.	.
en-wikipedia-org-3485	919	1	Neuropharmacology	neuropharmacology	NN
en-wikipedia-org-3485	919	2	.	.	.
en-wikipedia-org-3485	920	1	76	76	CD
en-wikipedia-org-3485	920	2	Pt	Pt	NNP
en-wikipedia-org-3485	920	3	B	B	NNP
en-wikipedia-org-3485	920	4	:	:	:
en-wikipedia-org-3485	920	5	351–9	351–9	CD
en-wikipedia-org-3485	920	6	.	.	.
en-wikipedia-org-3485	921	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	921	2	/	/	SYM
en-wikipedia-org-3485	921	3	j.neuropharm.2013.03.019	j.neuropharm.2013.03.019	CD
en-wikipedia-org-3485	921	4	.	.	.
en-wikipedia-org-3485	922	1	PMC	PMC	NNP
en-wikipedia-org-3485	922	2	 	  	_SP
en-wikipedia-org-3485	922	3	3778102	3778102	CD
en-wikipedia-org-3485	922	4	.	.	.
en-wikipedia-org-3485	923	1	PMID	PMID	NNP
en-wikipedia-org-3485	923	2	 	  	_SP
en-wikipedia-org-3485	923	3	23578393	23578393	CD
en-wikipedia-org-3485	923	4	.	.	.
en-wikipedia-org-3485	924	1	^	^	NNP
en-wikipedia-org-3485	924	2	Knowland	Knowland	NNP
en-wikipedia-org-3485	924	3	,	,	,
en-wikipedia-org-3485	924	4	D	D	NNP
en-wikipedia-org-3485	924	5	;	;	:
en-wikipedia-org-3485	924	6	Lim	Lim	NNP
en-wikipedia-org-3485	924	7	,	,	,
en-wikipedia-org-3485	924	8	BK	BK	NNP
en-wikipedia-org-3485	924	9	(	(	-LRB-
en-wikipedia-org-3485	924	10	5	5	CD
en-wikipedia-org-3485	924	11	January	January	NNP
en-wikipedia-org-3485	924	12	2018	2018	CD
en-wikipedia-org-3485	924	13	)	)	-RRB-
en-wikipedia-org-3485	924	14	.	.	.
en-wikipedia-org-3485	925	1	"	"	``
en-wikipedia-org-3485	925	2	Circuit	circuit	NN
en-wikipedia-org-3485	925	3	-	-	HYPH
en-wikipedia-org-3485	925	4	based	base	VBN
en-wikipedia-org-3485	925	5	frameworks	framework	NNS
en-wikipedia-org-3485	925	6	of	of	IN
en-wikipedia-org-3485	925	7	depressive	depressive	JJ
en-wikipedia-org-3485	925	8	behaviors	behavior	NNS
en-wikipedia-org-3485	925	9	:	:	:
en-wikipedia-org-3485	925	10	The	the	DT
en-wikipedia-org-3485	925	11	role	role	NN
en-wikipedia-org-3485	925	12	of	of	IN
en-wikipedia-org-3485	925	13	reward	reward	NN
en-wikipedia-org-3485	925	14	circuitry	circuitry	NN
en-wikipedia-org-3485	925	15	and	and	CC
en-wikipedia-org-3485	925	16	beyond	beyond	IN
en-wikipedia-org-3485	925	17	"	"	''
en-wikipedia-org-3485	925	18	.	.	.
en-wikipedia-org-3485	926	1	Pharmacology	Pharmacology	NNP
en-wikipedia-org-3485	926	2	Biochemistry	Biochemistry	NNP
en-wikipedia-org-3485	926	3	and	and	CC
en-wikipedia-org-3485	926	4	Behavior	Behavior	NNP
en-wikipedia-org-3485	926	5	.	.	.
en-wikipedia-org-3485	927	1	174	174	CD
en-wikipedia-org-3485	927	2	:	:	SYM
en-wikipedia-org-3485	927	3	42–52	42–52	CD
en-wikipedia-org-3485	927	4	.	.	.
en-wikipedia-org-3485	928	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-3485	928	2	/	/	SYM
en-wikipedia-org-3485	928	3	j.pbb.2017.12.010	j.pbb.2017.12.010	NNP
en-wikipedia-org-3485	928	4	.	.	.
en-wikipedia-org-3485	929	1	PMC	PMC	NNP
en-wikipedia-org-3485	929	2	 	  	_SP
en-wikipedia-org-3485	929	3	6340396	6340396	CD
en-wikipedia-org-3485	929	4	.	.	.
en-wikipedia-org-3485	930	1	PMID	PMID	NNP
en-wikipedia-org-3485	930	2	 	  	_SP
en-wikipedia-org-3485	930	3	29309799	29309799	CD
en-wikipedia-org-3485	930	4	.	.	.
en-wikipedia-org-3485	931	1	^	^	NNP
en-wikipedia-org-3485	931	2	a	a	DT
en-wikipedia-org-3485	931	3	b	b	NNP
en-wikipedia-org-3485	931	4	Lammel	Lammel	NNP
en-wikipedia-org-3485	931	5	,	,	,
en-wikipedia-org-3485	931	6	S	S	NNP
en-wikipedia-org-3485	931	7	;	;	:
en-wikipedia-org-3485	931	8	Tye	Tye	NNP
en-wikipedia-org-3485	931	9	,	,	,
en-wikipedia-org-3485	931	10	KM	KM	NNP
en-wikipedia-org-3485	931	11	;	;	:
en-wikipedia-org-3485	931	12	Warden	Warden	NNP
en-wikipedia-org-3485	931	13	,	,	,
en-wikipedia-org-3485	931	14	MR	MR	NNP
en-wikipedia-org-3485	931	15	(	(	-LRB-
en-wikipedia-org-3485	931	16	January	January	NNP
en-wikipedia-org-3485	931	17	2014	2014	CD
en-wikipedia-org-3485	931	18	)	)	-RRB-
en-wikipedia-org-3485	931	19	.	.	.
en-wikipedia-org-3485	932	1	"	"	``
en-wikipedia-org-3485	932	2	Progress	progress	NN
en-wikipedia-org-3485	932	3	in	in	IN
en-wikipedia-org-3485	932	4	understanding	understand	VBG
en-wikipedia-org-3485	932	5	mood	mood	NN
en-wikipedia-org-3485	932	6	disorders	disorder	NNS
en-wikipedia-org-3485	932	7	:	:	:
en-wikipedia-org-3485	932	8	optogenetic	optogenetic	JJ
en-wikipedia-org-3485	932	9	dissection	dissection	NN
en-wikipedia-org-3485	932	10	of	of	IN
en-wikipedia-org-3485	932	11	neural	neural	JJ
en-wikipedia-org-3485	932	12	circuits	circuit	NNS
en-wikipedia-org-3485	932	13	"	"	''
en-wikipedia-org-3485	932	14	.	.	.
en-wikipedia-org-3485	933	1	Genes	Genes	NNP
en-wikipedia-org-3485	933	2	,	,	,
en-wikipedia-org-3485	933	3	Brain	Brain	NNP
en-wikipedia-org-3485	933	4	,	,	,
en-wikipedia-org-3485	933	5	and	and	CC
en-wikipedia-org-3485	933	6	Behavior	Behavior	NNP
en-wikipedia-org-3485	933	7	.	.	.
en-wikipedia-org-3485	934	1	13	13	CD
en-wikipedia-org-3485	934	2	(	(	-LRB-
en-wikipedia-org-3485	934	3	1	1	CD
en-wikipedia-org-3485	934	4	)	)	-RRB-
en-wikipedia-org-3485	934	5	:	:	:
en-wikipedia-org-3485	934	6	38–51	38–51	LS
en-wikipedia-org-3485	934	7	.	.	.
en-wikipedia-org-3485	935	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-3485	935	2	/	/	SYM
en-wikipedia-org-3485	935	3	gbb.12049	gbb.12049	NN
en-wikipedia-org-3485	935	4	.	.	.
en-wikipedia-org-3485	936	1	PMID	PMID	NNP
en-wikipedia-org-3485	936	2	 	  	_SP
en-wikipedia-org-3485	936	3	23682971	23682971	CD
en-wikipedia-org-3485	936	4	.	.	.
en-wikipedia-org-3485	937	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	937	2	 	  	_SP
en-wikipedia-org-3485	937	3	18542868	18542868	CD
en-wikipedia-org-3485	937	4	.	.	.
en-wikipedia-org-3485	938	1	^	^	NNP
en-wikipedia-org-3485	938	2	Bucci	Bucci	NNP
en-wikipedia-org-3485	938	3	,	,	,
en-wikipedia-org-3485	938	4	P	P	NNP
en-wikipedia-org-3485	938	5	;	;	:
en-wikipedia-org-3485	938	6	Galderisi	Galderisi	NNP
en-wikipedia-org-3485	938	7	,	,	,
en-wikipedia-org-3485	938	8	S	S	NNP
en-wikipedia-org-3485	938	9	(	(	-LRB-
en-wikipedia-org-3485	938	10	May	May	NNP
en-wikipedia-org-3485	938	11	2017	2017	CD
en-wikipedia-org-3485	938	12	)	)	-RRB-
en-wikipedia-org-3485	938	13	.	.	.
en-wikipedia-org-3485	939	1	"	"	``
en-wikipedia-org-3485	939	2	Categorizing	categorize	VBG
en-wikipedia-org-3485	939	3	and	and	CC
en-wikipedia-org-3485	939	4	assessing	assess	VBG
en-wikipedia-org-3485	939	5	negative	negative	JJ
en-wikipedia-org-3485	939	6	symptoms	symptom	NNS
en-wikipedia-org-3485	939	7	"	"	''
en-wikipedia-org-3485	939	8	.	.	.
en-wikipedia-org-3485	940	1	Current	current	JJ
en-wikipedia-org-3485	940	2	Opinion	Opinion	NNP
en-wikipedia-org-3485	940	3	in	in	IN
en-wikipedia-org-3485	940	4	Psychiatry	Psychiatry	NNP
en-wikipedia-org-3485	940	5	.	.	.
en-wikipedia-org-3485	941	1	30	30	CD
en-wikipedia-org-3485	941	2	(	(	-LRB-
en-wikipedia-org-3485	941	3	3	3	CD
en-wikipedia-org-3485	941	4	)	)	-RRB-
en-wikipedia-org-3485	941	5	:	:	:
en-wikipedia-org-3485	941	6	201–208	201–208	CD
en-wikipedia-org-3485	941	7	.	.	.
en-wikipedia-org-3485	942	1	doi:10.1097	doi:10.1097	NNP
en-wikipedia-org-3485	942	2	/	/	SYM
en-wikipedia-org-3485	942	3	YCO.0000000000000322	YCO.0000000000000322	NNP
en-wikipedia-org-3485	942	4	.	.	.
en-wikipedia-org-3485	943	1	PMID	PMID	NNP
en-wikipedia-org-3485	943	2	 	  	_SP
en-wikipedia-org-3485	943	3	28212174	28212174	CD
en-wikipedia-org-3485	943	4	.	.	.
en-wikipedia-org-3485	944	1	S2CID	S2CID	NNS
en-wikipedia-org-3485	944	2	 	  	_SP
en-wikipedia-org-3485	944	3	9923114	9923114	CD
en-wikipedia-org-3485	944	4	.	.	.
en-wikipedia-org-3485	945	1	They	-PRON-	PRP
en-wikipedia-org-3485	945	2	also	also	RB
en-wikipedia-org-3485	945	3	provide	provide	VBP
en-wikipedia-org-3485	945	4	a	a	DT
en-wikipedia-org-3485	945	5	separate	separate	JJ
en-wikipedia-org-3485	945	6	assessment	assessment	NN
en-wikipedia-org-3485	945	7	of	of	IN
en-wikipedia-org-3485	945	8	the	the	DT
en-wikipedia-org-3485	945	9	consummatory	consummatory	NN
en-wikipedia-org-3485	945	10	anhedonia	anhedonia	NNP
en-wikipedia-org-3485	945	11	(	(	-LRB-
en-wikipedia-org-3485	945	12	reduced	reduce	VBN
en-wikipedia-org-3485	945	13	experience	experience	NN
en-wikipedia-org-3485	945	14	of	of	IN
en-wikipedia-org-3485	945	15	pleasure	pleasure	NN
en-wikipedia-org-3485	945	16	derived	derive	VBN
en-wikipedia-org-3485	945	17	from	from	IN
en-wikipedia-org-3485	945	18	ongoing	ongoing	JJ
en-wikipedia-org-3485	945	19	enjoyable	enjoyable	JJ
en-wikipedia-org-3485	945	20	activities	activity	NNS
en-wikipedia-org-3485	945	21	)	)	-RRB-
en-wikipedia-org-3485	945	22	and	and	CC
en-wikipedia-org-3485	945	23	anticipatory	anticipatory	JJ
en-wikipedia-org-3485	945	24	anhedonia	anhedonia	NNP
en-wikipedia-org-3485	945	25	(	(	-LRB-
en-wikipedia-org-3485	945	26	reduced	reduce	VBN
en-wikipedia-org-3485	945	27	ability	ability	NN
en-wikipedia-org-3485	945	28	to	to	TO
en-wikipedia-org-3485	945	29	anticipate	anticipate	VB
en-wikipedia-org-3485	945	30	future	future	JJ
en-wikipedia-org-3485	945	31	pleasure	pleasure	NN
en-wikipedia-org-3485	945	32	)	)	-RRB-
en-wikipedia-org-3485	945	33	.	.	.
en-wikipedia-org-3485	946	1	In	in	IN
en-wikipedia-org-3485	946	2	fact	fact	NN
en-wikipedia-org-3485	946	3	,	,	,
en-wikipedia-org-3485	946	4	the	the	DT
en-wikipedia-org-3485	946	5	former	former	JJ
en-wikipedia-org-3485	946	6	one	one	NN
en-wikipedia-org-3485	946	7	seems	seem	VBZ
en-wikipedia-org-3485	946	8	to	to	TO
en-wikipedia-org-3485	946	9	be	be	VB
en-wikipedia-org-3485	946	10	relatively	relatively	RB
en-wikipedia-org-3485	946	11	intact	intact	JJ
en-wikipedia-org-3485	946	12	in	in	IN
en-wikipedia-org-3485	946	13	schizophrenia	schizophrenia	NN
en-wikipedia-org-3485	946	14	,	,	,
en-wikipedia-org-3485	946	15	whereas	whereas	IN
en-wikipedia-org-3485	946	16	the	the	DT
en-wikipedia-org-3485	946	17	latter	latter	JJ
en-wikipedia-org-3485	946	18	one	one	NN
en-wikipedia-org-3485	946	19	seems	seem	VBZ
en-wikipedia-org-3485	946	20	to	to	TO
en-wikipedia-org-3485	946	21	be	be	VB
en-wikipedia-org-3485	946	22	impaired	impair	VBN
en-wikipedia-org-3485	946	23	[	[	-LRB-
en-wikipedia-org-3485	946	24	32	32	CD
en-wikipedia-org-3485	946	25	–	–	SYM
en-wikipedia-org-3485	946	26	34	34	CD
en-wikipedia-org-3485	946	27	]	]	-RRB-
en-wikipedia-org-3485	946	28	.	.	.
en-wikipedia-org-3485	947	1	However	however	RB
en-wikipedia-org-3485	947	2	,	,	,
en-wikipedia-org-3485	947	3	discrepant	discrepant	JJ
en-wikipedia-org-3485	947	4	data	datum	NNS
en-wikipedia-org-3485	947	5	have	have	VBP
en-wikipedia-org-3485	947	6	also	also	RB
en-wikipedia-org-3485	947	7	been	be	VBN
en-wikipedia-org-3485	947	8	reported	report	VBN
en-wikipedia-org-3485	947	9	[	[	-LRB-
en-wikipedia-org-3485	947	10	35	35	CD
en-wikipedia-org-3485	947	11	]	]	-RRB-
en-wikipedia-org-3485	947	12	.	.	.
en-wikipedia-org-3485	948	1	^	^	NNP
en-wikipedia-org-3485	948	2	Young	Young	NNP
en-wikipedia-org-3485	948	3	2018	2018	CD
en-wikipedia-org-3485	948	4	,	,	,
en-wikipedia-org-3485	948	5	p.	p.	NN
en-wikipedia-org-3485	948	6	 	  	_SP
en-wikipedia-org-3485	948	7	215a,"Several	215a,"several	JJ
en-wikipedia-org-3485	948	8	recent	recent	JJ
en-wikipedia-org-3485	948	9	reviews	review	NNS
en-wikipedia-org-3485	948	10	(	(	-LRB-
en-wikipedia-org-3485	948	11	e.g.	e.g.	RB
en-wikipedia-org-3485	948	12	,	,	,
en-wikipedia-org-3485	948	13	Cohen	Cohen	NNP
en-wikipedia-org-3485	948	14	and	and	CC
en-wikipedia-org-3485	948	15	Minor	Minor	NNP
en-wikipedia-org-3485	948	16	,	,	,
en-wikipedia-org-3485	948	17	2010	2010	CD
en-wikipedia-org-3485	948	18	)	)	-RRB-
en-wikipedia-org-3485	948	19	have	have	VBP
en-wikipedia-org-3485	948	20	found	find	VBN
en-wikipedia-org-3485	948	21	that	that	IN
en-wikipedia-org-3485	948	22	individuals	individual	NNS
en-wikipedia-org-3485	948	23	with	with	IN
en-wikipedia-org-3485	948	24	schizophrenia	schizophrenia	NN
en-wikipedia-org-3485	948	25	show	show	VBP
en-wikipedia-org-3485	948	26	relatively	relatively	RB
en-wikipedia-org-3485	948	27	intact	intact	JJ
en-wikipedia-org-3485	948	28	self	self	NN
en-wikipedia-org-3485	948	29	-	-	HYPH
en-wikipedia-org-3485	948	30	reported	report	VBN
en-wikipedia-org-3485	948	31	emotional	emotional	JJ
en-wikipedia-org-3485	948	32	responses	response	NNS
en-wikipedia-org-3485	948	33	to	to	TO
en-wikipedia-org-3485	948	34	affect	affect	VB
en-wikipedia-org-3485	948	35	-	-	HYPH
en-wikipedia-org-3485	948	36	eliciting	elicit	VBG
en-wikipedia-org-3485	948	37	stimuli	stimulus	NNS
en-wikipedia-org-3485	948	38	as	as	RB
en-wikipedia-org-3485	948	39	well	well	RB
en-wikipedia-org-3485	948	40	as	as	IN
en-wikipedia-org-3485	948	41	other	other	JJ
en-wikipedia-org-3485	948	42	indicators	indicator	NNS
en-wikipedia-org-3485	948	43	of	of	IN
en-wikipedia-org-3485	948	44	intact	intact	JJ
en-wikipedia-org-3485	948	45	response	response	NN
en-wikipedia-org-3485	948	46	...	...	:
en-wikipedia-org-3485	948	47	A	a	DT
en-wikipedia-org-3485	948	48	more	more	RBR
en-wikipedia-org-3485	948	49	mixed	mixed	JJ
en-wikipedia-org-3485	948	50	picture	picture	NN
en-wikipedia-org-3485	948	51	arises	arise	VBZ
en-wikipedia-org-3485	948	52	from	from	IN
en-wikipedia-org-3485	948	53	functional	functional	JJ
en-wikipedia-org-3485	948	54	neuroimaging	neuroimaging	JJ
en-wikipedia-org-3485	948	55	studies	study	NNS
en-wikipedia-org-3485	948	56	examining	examine	VBG
en-wikipedia-org-3485	948	57	brain	brain	NN
en-wikipedia-org-3485	948	58	responses	response	NNS
en-wikipedia-org-3485	948	59	to	to	IN
en-wikipedia-org-3485	948	60	other	other	JJ
en-wikipedia-org-3485	948	61	types	type	NNS
en-wikipedia-org-3485	948	62	of	of	IN
en-wikipedia-org-3485	948	63	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	948	64	stimuli	stimulus	NNS
en-wikipedia-org-3485	948	65	in	in	IN
en-wikipedia-org-3485	948	66	schizophrenia	schizophrenia	NNP
en-wikipedia-org-3485	948	67	(	(	-LRB-
en-wikipedia-org-3485	948	68	Paradiso	Paradiso	NNP
en-wikipedia-org-3485	948	69	et	et	NNP
en-wikipedia-org-3485	948	70	al	al	NNP
en-wikipedia-org-3485	948	71	.	.	NNP
en-wikipedia-org-3485	948	72	,	,	,
en-wikipedia-org-3485	948	73	2003	2003	CD
en-wikipedia-org-3485	948	74	)	)	-RRB-
en-wikipedia-org-3485	948	75	"	"	``
en-wikipedia-org-3485	948	76	sfn	sfn	NNP
en-wikipedia-org-3485	948	77	error	error	NN
en-wikipedia-org-3485	948	78	:	:	:
en-wikipedia-org-3485	948	79	no	no	DT
en-wikipedia-org-3485	948	80	target	target	NN
en-wikipedia-org-3485	948	81	:	:	:
en-wikipedia-org-3485	948	82	CITEREFYoung2018	CITEREFYoung2018	NNP
en-wikipedia-org-3485	948	83	(	(	-LRB-
en-wikipedia-org-3485	948	84	help	help	NN
en-wikipedia-org-3485	948	85	)	)	-RRB-
en-wikipedia-org-3485	948	86	^	^	.
en-wikipedia-org-3485	948	87	Young	young	JJ
en-wikipedia-org-3485	948	88	2018	2018	CD
en-wikipedia-org-3485	948	89	,	,	,
en-wikipedia-org-3485	948	90	p.	p.	NN
en-wikipedia-org-3485	948	91	 	  	_SP
en-wikipedia-org-3485	948	92	215b,"As	215b,"as	CD
en-wikipedia-org-3485	948	93	such	such	JJ
en-wikipedia-org-3485	948	94	it	-PRON-	PRP
en-wikipedia-org-3485	948	95	is	be	VBZ
en-wikipedia-org-3485	948	96	surprising	surprising	JJ
en-wikipedia-org-3485	948	97	that	that	IN
en-wikipedia-org-3485	948	98	behavioral	behavioral	JJ
en-wikipedia-org-3485	948	99	studies	study	NNS
en-wikipedia-org-3485	948	100	have	have	VBP
en-wikipedia-org-3485	948	101	suggested	suggest	VBN
en-wikipedia-org-3485	948	102	that	that	IN
en-wikipedia-org-3485	948	103	reinforcement	reinforcement	NN
en-wikipedia-org-3485	948	104	learning	learning	NN
en-wikipedia-org-3485	948	105	is	be	VBZ
en-wikipedia-org-3485	948	106	intact	intact	JJ
en-wikipedia-org-3485	948	107	in	in	IN
en-wikipedia-org-3485	948	108	schizophrenia	schizophrenia	NN
en-wikipedia-org-3485	948	109	when	when	WRB
en-wikipedia-org-3485	948	110	learning	learning	NN
en-wikipedia-org-3485	948	111	is	be	VBZ
en-wikipedia-org-3485	948	112	relatively	relatively	RB
en-wikipedia-org-3485	948	113	implicit	implicit	JJ
en-wikipedia-org-3485	948	114	(	(	-LRB-
en-wikipedia-org-3485	948	115	though	though	RB
en-wikipedia-org-3485	948	116	,	,	,
en-wikipedia-org-3485	948	117	see	see	VB
en-wikipedia-org-3485	948	118	Siegert	Siegert	NNP
en-wikipedia-org-3485	948	119	et	et	FW
en-wikipedia-org-3485	948	120	al	al	NNP
en-wikipedia-org-3485	948	121	.	.	NNP
en-wikipedia-org-3485	948	122	,	,	,
en-wikipedia-org-3485	948	123	2008	2008	CD
en-wikipedia-org-3485	948	124	for	for	IN
en-wikipedia-org-3485	948	125	evidence	evidence	NN
en-wikipedia-org-3485	948	126	of	of	IN
en-wikipedia-org-3485	948	127	impaired	impaired	JJ
en-wikipedia-org-3485	948	128	Serial	Serial	NNP
en-wikipedia-org-3485	948	129	Reaction	Reaction	NNP
en-wikipedia-org-3485	948	130	Time	Time	NNP
en-wikipedia-org-3485	948	131	task	task	NN
en-wikipedia-org-3485	948	132	learning	learning	NN
en-wikipedia-org-3485	948	133	)	)	-RRB-
en-wikipedia-org-3485	948	134	,	,	,
en-wikipedia-org-3485	948	135	but	but	CC
en-wikipedia-org-3485	948	136	more	more	RBR
en-wikipedia-org-3485	948	137	impaired	impaired	JJ
en-wikipedia-org-3485	948	138	when	when	WRB
en-wikipedia-org-3485	948	139	explicit	explicit	JJ
en-wikipedia-org-3485	948	140	representations	representation	NNS
en-wikipedia-org-3485	948	141	of	of	IN
en-wikipedia-org-3485	948	142	stimulus	stimulus	JJ
en-wikipedia-org-3485	948	143	-	-	HYPH
en-wikipedia-org-3485	948	144	reward	reward	NN
en-wikipedia-org-3485	948	145	contingencies	contingency	NNS
en-wikipedia-org-3485	948	146	are	be	VBP
en-wikipedia-org-3485	948	147	needed	need	VBN
en-wikipedia-org-3485	948	148	(	(	-LRB-
en-wikipedia-org-3485	948	149	see	see	VB
en-wikipedia-org-3485	948	150	Gold	Gold	NNP
en-wikipedia-org-3485	948	151	et	et	NNP
en-wikipedia-org-3485	948	152	al	al	NNP
en-wikipedia-org-3485	948	153	.	.	NNP
en-wikipedia-org-3485	948	154	,	,	,
en-wikipedia-org-3485	948	155	2008	2008	CD
en-wikipedia-org-3485	948	156	)	)	-RRB-
en-wikipedia-org-3485	948	157	.	.	.
en-wikipedia-org-3485	949	1	This	this	DT
en-wikipedia-org-3485	949	2	pattern	pattern	NN
en-wikipedia-org-3485	949	3	has	have	VBZ
en-wikipedia-org-3485	949	4	given	give	VBN
en-wikipedia-org-3485	949	5	rise	rise	NN
en-wikipedia-org-3485	949	6	to	to	IN
en-wikipedia-org-3485	949	7	the	the	DT
en-wikipedia-org-3485	949	8	theory	theory	NN
en-wikipedia-org-3485	949	9	that	that	IN
en-wikipedia-org-3485	949	10	the	the	DT
en-wikipedia-org-3485	949	11	striatally	striatally	RB
en-wikipedia-org-3485	949	12	mediated	mediate	VBN
en-wikipedia-org-3485	949	13	gradual	gradual	JJ
en-wikipedia-org-3485	949	14	reinforcement	reinforcement	NN
en-wikipedia-org-3485	949	15	learning	learning	NN
en-wikipedia-org-3485	949	16	system	system	NN
en-wikipedia-org-3485	949	17	may	may	MD
en-wikipedia-org-3485	949	18	be	be	VB
en-wikipedia-org-3485	949	19	intact	intact	JJ
en-wikipedia-org-3485	949	20	in	in	IN
en-wikipedia-org-3485	949	21	schizophrenia	schizophrenia	NN
en-wikipedia-org-3485	949	22	,	,	,
en-wikipedia-org-3485	949	23	while	while	IN
en-wikipedia-org-3485	949	24	more	more	RBR
en-wikipedia-org-3485	949	25	rapid	rapid	JJ
en-wikipedia-org-3485	949	26	,	,	,
en-wikipedia-org-3485	949	27	on	on	IN
en-wikipedia-org-3485	949	28	-	-	HYPH
en-wikipedia-org-3485	949	29	line	line	NN
en-wikipedia-org-3485	949	30	,	,	,
en-wikipedia-org-3485	949	31	cortically	cortically	RB
en-wikipedia-org-3485	949	32	mediated	mediate	VBN
en-wikipedia-org-3485	949	33	learning	learning	NN
en-wikipedia-org-3485	949	34	systems	system	NNS
en-wikipedia-org-3485	949	35	are	be	VBP
en-wikipedia-org-3485	949	36	impaired	impair	VBN
en-wikipedia-org-3485	949	37	.	.	.
en-wikipedia-org-3485	949	38	"	"	''
en-wikipedia-org-3485	950	1	sfn	sfn	NNP
en-wikipedia-org-3485	950	2	error	error	NNP
en-wikipedia-org-3485	950	3	:	:	:
en-wikipedia-org-3485	950	4	no	no	DT
en-wikipedia-org-3485	950	5	target	target	NN
en-wikipedia-org-3485	950	6	:	:	:
en-wikipedia-org-3485	950	7	CITEREFYoung2018	CITEREFYoung2018	NNP
en-wikipedia-org-3485	950	8	(	(	-LRB-
en-wikipedia-org-3485	950	9	help	help	NN
en-wikipedia-org-3485	950	10	)	)	-RRB-
en-wikipedia-org-3485	950	11	^	^	.
en-wikipedia-org-3485	950	12	Young	young	JJ
en-wikipedia-org-3485	950	13	2018	2018	CD
en-wikipedia-org-3485	950	14	,	,	,
en-wikipedia-org-3485	950	15	p.	p.	NN
en-wikipedia-org-3485	950	16	 	  	_SP
en-wikipedia-org-3485	950	17	216	216	CD
en-wikipedia-org-3485	950	18	,	,	,
en-wikipedia-org-3485	950	19	"	"	``
en-wikipedia-org-3485	950	20	We	-PRON-	PRP
en-wikipedia-org-3485	950	21	have	have	VBP
en-wikipedia-org-3485	950	22	recently	recently	RB
en-wikipedia-org-3485	950	23	shown	show	VBN
en-wikipedia-org-3485	950	24	that	that	IN
en-wikipedia-org-3485	950	25	individuals	individual	NNS
en-wikipedia-org-3485	950	26	with	with	IN
en-wikipedia-org-3485	950	27	schizophrenia	schizophrenia	NN
en-wikipedia-org-3485	950	28	can	can	MD
en-wikipedia-org-3485	950	29	show	show	VB
en-wikipedia-org-3485	950	30	improved	improve	VBN
en-wikipedia-org-3485	950	31	cognitive	cognitive	JJ
en-wikipedia-org-3485	950	32	control	control	NN
en-wikipedia-org-3485	950	33	performance	performance	NN
en-wikipedia-org-3485	950	34	when	when	WRB
en-wikipedia-org-3485	950	35	information	information	NN
en-wikipedia-org-3485	950	36	about	about	IN
en-wikipedia-org-3485	950	37	rewards	reward	NNS
en-wikipedia-org-3485	950	38	are	be	VBP
en-wikipedia-org-3485	950	39	externally	externally	RB
en-wikipedia-org-3485	950	40	presented	present	VBN
en-wikipedia-org-3485	950	41	but	but	CC
en-wikipedia-org-3485	950	42	not	not	RB
en-wikipedia-org-3485	950	43	when	when	WRB
en-wikipedia-org-3485	950	44	they	-PRON-	PRP
en-wikipedia-org-3485	950	45	must	must	MD
en-wikipedia-org-3485	950	46	be	be	VB
en-wikipedia-org-3485	950	47	internally	internally	RB
en-wikipedia-org-3485	950	48	maintained	maintain	VBN
en-wikipedia-org-3485	950	49	(	(	-LRB-
en-wikipedia-org-3485	950	50	Mann	Mann	NNP
en-wikipedia-org-3485	950	51	et	et	NNP
en-wikipedia-org-3485	950	52	al	al	NNP
en-wikipedia-org-3485	950	53	.	.	NNP
en-wikipedia-org-3485	950	54	,	,	,
en-wikipedia-org-3485	950	55	2013	2013	CD
en-wikipedia-org-3485	950	56	)	)	-RRB-
en-wikipedia-org-3485	950	57	,	,	,
en-wikipedia-org-3485	950	58	with	with	IN
en-wikipedia-org-3485	950	59	some	some	DT
en-wikipedia-org-3485	950	60	evidence	evidence	NN
en-wikipedia-org-3485	950	61	for	for	IN
en-wikipedia-org-3485	950	62	impairments	impairment	NNS
en-wikipedia-org-3485	950	63	in	in	IN
en-wikipedia-org-3485	950	64	DLPFC	DLPFC	NNP
en-wikipedia-org-3485	950	65	and	and	CC
en-wikipedia-org-3485	950	66	striatal	striatal	JJ
en-wikipedia-org-3485	950	67	activation	activation	NN
en-wikipedia-org-3485	950	68	during	during	IN
en-wikipedia-org-3485	950	69	internal	internal	JJ
en-wikipedia-org-3485	950	70	maintenance	maintenance	NN
en-wikipedia-org-3485	950	71	of	of	IN
en-wikipedia-org-3485	950	72	reward	reward	NN
en-wikipedia-org-3485	950	73	information	information	NN
en-wikipedia-org-3485	950	74	being	be	VBG
en-wikipedia-org-3485	950	75	associated	associate	VBN
en-wikipedia-org-3485	950	76	with	with	IN
en-wikipedia-org-3485	950	77	individuals	individual	NNS
en-wikipedia-org-3485	950	78	’	’	POS
en-wikipedia-org-3485	950	79	differences	difference	NNS
en-wikipedia-org-3485	950	80	in	in	IN
en-wikipedia-org-3485	950	81	motivation	motivation	NN
en-wikipedia-org-3485	950	82	(	(	-LRB-
en-wikipedia-org-3485	950	83	Chung	Chung	NNP
en-wikipedia-org-3485	950	84	and	and	CC
en-wikipedia-org-3485	950	85	Barch	Barch	NNP
en-wikipedia-org-3485	950	86	,	,	,
en-wikipedia-org-3485	950	87	2016	2016	CD
en-wikipedia-org-3485	950	88	)	)	-RRB-
en-wikipedia-org-3485	950	89	.	.	.
en-wikipedia-org-3485	950	90	"	"	''
en-wikipedia-org-3485	951	1	sfn	sfn	NNP
en-wikipedia-org-3485	951	2	error	error	NNP
en-wikipedia-org-3485	951	3	:	:	:
en-wikipedia-org-3485	951	4	no	no	DT
en-wikipedia-org-3485	951	5	target	target	NN
en-wikipedia-org-3485	951	6	:	:	:
en-wikipedia-org-3485	951	7	CITEREFYoung2018	CITEREFYoung2018	NNP
en-wikipedia-org-3485	951	8	(	(	-LRB-
en-wikipedia-org-3485	951	9	help	help	NN
en-wikipedia-org-3485	951	10	)	)	-RRB-
en-wikipedia-org-3485	951	11	^	^	.
en-wikipedia-org-3485	951	12	Wise	Wise	NNP
en-wikipedia-org-3485	951	13	RA	RA	NNP
en-wikipedia-org-3485	951	14	(	(	-LRB-
en-wikipedia-org-3485	951	15	1996	1996	CD
en-wikipedia-org-3485	951	16	)	)	-RRB-
en-wikipedia-org-3485	951	17	.	.	.
en-wikipedia-org-3485	952	1	"	"	``
en-wikipedia-org-3485	952	2	Addictive	addictive	JJ
en-wikipedia-org-3485	952	3	drugs	drug	NNS
en-wikipedia-org-3485	952	4	and	and	CC
en-wikipedia-org-3485	952	5	brain	brain	NN
en-wikipedia-org-3485	952	6	stimulation	stimulation	NN
en-wikipedia-org-3485	952	7	reward	reward	NN
en-wikipedia-org-3485	952	8	"	"	''
en-wikipedia-org-3485	952	9	.	.	.
en-wikipedia-org-3485	953	1	Annu	Annu	NNP
en-wikipedia-org-3485	953	2	.	.	.
en-wikipedia-org-3485	954	1	Rev.	Rev.	NNP
en-wikipedia-org-3485	955	1	Neurosci	Neurosci	NNP
en-wikipedia-org-3485	955	2	.	.	.
en-wikipedia-org-3485	956	1	19	19	CD
en-wikipedia-org-3485	956	2	:	:	:
en-wikipedia-org-3485	956	3	319–340	319–340	CD
en-wikipedia-org-3485	956	4	.	.	.
en-wikipedia-org-3485	957	1	doi:10.1146	doi:10.1146	NNP
en-wikipedia-org-3485	957	2	/	/	SYM
en-wikipedia-org-3485	957	3	annurev.ne.19.030196.001535	annurev.ne.19.030196.001535	FW
en-wikipedia-org-3485	957	4	.	.	.
en-wikipedia-org-3485	958	1	PMID	PMID	NNP
en-wikipedia-org-3485	958	2	 	  	_SP
en-wikipedia-org-3485	958	3	8833446	8833446	CD
en-wikipedia-org-3485	958	4	.	.	.
en-wikipedia-org-3485	959	1	^	^	NNP
en-wikipedia-org-3485	959	2	a	a	DT
en-wikipedia-org-3485	959	3	b	b	NNP
en-wikipedia-org-3485	959	4	"	"	``
en-wikipedia-org-3485	959	5	human	human	JJ
en-wikipedia-org-3485	959	6	nervous	nervous	JJ
en-wikipedia-org-3485	959	7	system	system	NN
en-wikipedia-org-3485	959	8	"	"	''
en-wikipedia-org-3485	959	9	.	.	.
en-wikipedia-org-3485	960	1	^	^	NNP
en-wikipedia-org-3485	960	2	a	a	DT
en-wikipedia-org-3485	960	3	b	b	NN
en-wikipedia-org-3485	960	4	James	James	NNP
en-wikipedia-org-3485	960	5	Olds	Olds	NNP
en-wikipedia-org-3485	960	6	and	and	CC
en-wikipedia-org-3485	960	7	Peter	Peter	NNP
en-wikipedia-org-3485	960	8	Milner	Milner	NNP
en-wikipedia-org-3485	960	9	(	(	-LRB-
en-wikipedia-org-3485	960	10	December	December	NNP
en-wikipedia-org-3485	960	11	1954	1954	CD
en-wikipedia-org-3485	960	12	)	)	-RRB-
en-wikipedia-org-3485	960	13	.	.	.
en-wikipedia-org-3485	961	1	"	"	``
en-wikipedia-org-3485	961	2	Positive	positive	JJ
en-wikipedia-org-3485	961	3	reinforcement	reinforcement	NN
en-wikipedia-org-3485	961	4	produced	produce	VBN
en-wikipedia-org-3485	961	5	by	by	IN
en-wikipedia-org-3485	961	6	electrical	electrical	JJ
en-wikipedia-org-3485	961	7	stimulation	stimulation	NN
en-wikipedia-org-3485	961	8	of	of	IN
en-wikipedia-org-3485	961	9	the	the	DT
en-wikipedia-org-3485	961	10	septal	septal	JJ
en-wikipedia-org-3485	961	11	area	area	NN
en-wikipedia-org-3485	961	12	and	and	CC
en-wikipedia-org-3485	961	13	other	other	JJ
en-wikipedia-org-3485	961	14	regions	region	NNS
en-wikipedia-org-3485	961	15	of	of	IN
en-wikipedia-org-3485	961	16	rat	rat	NN
en-wikipedia-org-3485	961	17	brain	brain	NN
en-wikipedia-org-3485	961	18	"	"	''
en-wikipedia-org-3485	961	19	.	.	.
en-wikipedia-org-3485	962	1	Journal	Journal	NNP
en-wikipedia-org-3485	962	2	of	of	IN
en-wikipedia-org-3485	962	3	Comparative	Comparative	NNP
en-wikipedia-org-3485	962	4	and	and	CC
en-wikipedia-org-3485	962	5	Physiological	Physiological	NNP
en-wikipedia-org-3485	962	6	Psychology	Psychology	NNP
en-wikipedia-org-3485	962	7	.	.	.
en-wikipedia-org-3485	963	1	47	47	CD
en-wikipedia-org-3485	963	2	(	(	-LRB-
en-wikipedia-org-3485	963	3	6	6	CD
en-wikipedia-org-3485	963	4	)	)	-RRB-
en-wikipedia-org-3485	963	5	:	:	:
en-wikipedia-org-3485	963	6	419–427	419–427	CD
en-wikipedia-org-3485	963	7	.	.	.
en-wikipedia-org-3485	964	1	doi:10.1037	doi:10.1037	NNP
en-wikipedia-org-3485	964	2	/	/	SYM
en-wikipedia-org-3485	964	3	h0058775	h0058775	JJ
en-wikipedia-org-3485	964	4	.	.	.
en-wikipedia-org-3485	965	1	PMID	PMID	NNP
en-wikipedia-org-3485	965	2	 	  	_SP
en-wikipedia-org-3485	965	3	13233369	13233369	CD
en-wikipedia-org-3485	965	4	.	.	.
en-wikipedia-org-3485	966	1	^	^	FW
en-wikipedia-org-3485	966	2	"	"	``
en-wikipedia-org-3485	966	3	The	the	DT
en-wikipedia-org-3485	966	4	Functional	Functional	NNP
en-wikipedia-org-3485	966	5	Neuroanatomy	Neuroanatomy	NNP
en-wikipedia-org-3485	966	6	of	of	IN
en-wikipedia-org-3485	966	7	Pleasure	Pleasure	NNP
en-wikipedia-org-3485	966	8	and	and	CC
en-wikipedia-org-3485	966	9	Happiness	Happiness	NNP
en-wikipedia-org-3485	966	10	"	"	''
en-wikipedia-org-3485	966	11	.	.	.
en-wikipedia-org-3485	967	1	^	^	NNP
en-wikipedia-org-3485	967	2	Ivan	Ivan	NNP
en-wikipedia-org-3485	967	3	Petrovich	Petrovich	NNP
en-wikipedia-org-3485	967	4	Pavlov	Pavlov	NNP
en-wikipedia-org-3485	967	5	;	;	:
en-wikipedia-org-3485	967	6	G.	G.	NNP
en-wikipedia-org-3485	967	7	V.	V.	NNP
en-wikipedia-org-3485	967	8	Anrep	Anrep	NNP
en-wikipedia-org-3485	967	9	(	(	-LRB-
en-wikipedia-org-3485	967	10	2003	2003	CD
en-wikipedia-org-3485	967	11	)	)	-RRB-
en-wikipedia-org-3485	967	12	.	.	.
en-wikipedia-org-3485	968	1	Conditioned	Conditioned	NNP
en-wikipedia-org-3485	968	2	Reflexes	Reflexes	NNP
en-wikipedia-org-3485	968	3	.	.	.
en-wikipedia-org-3485	969	1	Courier	Courier	NNP
en-wikipedia-org-3485	969	2	Corporation	Corporation	NNP
en-wikipedia-org-3485	969	3	.	.	.
en-wikipedia-org-3485	970	1	pp	pp	NNP
en-wikipedia-org-3485	970	2	.	.	.
en-wikipedia-org-3485	971	1	1–.	1–.	CD
en-wikipedia-org-3485	972	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	972	2	 	  	_SP
en-wikipedia-org-3485	972	3	978	978	CD
en-wikipedia-org-3485	972	4	-	-	HYPH
en-wikipedia-org-3485	972	5	0	0	CD
en-wikipedia-org-3485	972	6	-	-	HYPH
en-wikipedia-org-3485	972	7	486	486	CD
en-wikipedia-org-3485	972	8	-	-	HYPH
en-wikipedia-org-3485	972	9	43093	43093	CD
en-wikipedia-org-3485	972	10	-	-	HYPH
en-wikipedia-org-3485	972	11	5	5	CD
en-wikipedia-org-3485	972	12	.	.	.
en-wikipedia-org-3485	973	1	^	^	NNP
en-wikipedia-org-3485	973	2	Fridlund	Fridlund	NNP
en-wikipedia-org-3485	973	3	,	,	,
en-wikipedia-org-3485	973	4	Alan	Alan	NNP
en-wikipedia-org-3485	973	5	and	and	CC
en-wikipedia-org-3485	973	6	James	James	NNP
en-wikipedia-org-3485	973	7	Kalat	Kalat	NNP
en-wikipedia-org-3485	973	8	.	.	.
en-wikipedia-org-3485	974	1	Mind	mind	NN
en-wikipedia-org-3485	974	2	and	and	CC
en-wikipedia-org-3485	974	3	Brain	Brain	NNP
en-wikipedia-org-3485	974	4	,	,	,
en-wikipedia-org-3485	974	5	the	the	DT
en-wikipedia-org-3485	974	6	Science	Science	NNP
en-wikipedia-org-3485	974	7	of	of	IN
en-wikipedia-org-3485	974	8	Psychology	Psychology	NNP
en-wikipedia-org-3485	974	9	.	.	.
en-wikipedia-org-3485	975	1	California	California	NNP
en-wikipedia-org-3485	975	2	:	:	:
en-wikipedia-org-3485	975	3	Cengage	Cengage	NNP
en-wikipedia-org-3485	975	4	Learning	Learning	NNP
en-wikipedia-org-3485	975	5	,	,	,
en-wikipedia-org-3485	975	6	2014	2014	CD
en-wikipedia-org-3485	975	7	.	.	.
en-wikipedia-org-3485	976	1	Print	print	NN
en-wikipedia-org-3485	976	2	.	.	.
en-wikipedia-org-3485	977	1	^	^	NNP
en-wikipedia-org-3485	977	2	a	a	DT
en-wikipedia-org-3485	977	3	b	b	NNP
en-wikipedia-org-3485	977	4	Berridge	Berridge	NNP
en-wikipedia-org-3485	977	5	,	,	,
en-wikipedia-org-3485	977	6	Kent	Kent	NNP
en-wikipedia-org-3485	977	7	C.	C.	NNP
en-wikipedia-org-3485	977	8	;	;	:
en-wikipedia-org-3485	977	9	Kringelbach	Kringelbach	NNP
en-wikipedia-org-3485	977	10	,	,	,
en-wikipedia-org-3485	977	11	Morten	Morten	NNP
en-wikipedia-org-3485	977	12	L.	L.	NNP
en-wikipedia-org-3485	977	13	(	(	-LRB-
en-wikipedia-org-3485	977	14	August	August	NNP
en-wikipedia-org-3485	977	15	2008	2008	CD
en-wikipedia-org-3485	977	16	)	)	-RRB-
en-wikipedia-org-3485	977	17	.	.	.
en-wikipedia-org-3485	978	1	"	"	``
en-wikipedia-org-3485	978	2	Affective	affective	JJ
en-wikipedia-org-3485	978	3	neuroscience	neuroscience	NN
en-wikipedia-org-3485	978	4	of	of	IN
en-wikipedia-org-3485	978	5	pleasure	pleasure	NN
en-wikipedia-org-3485	978	6	:	:	:
en-wikipedia-org-3485	978	7	reward	reward	VB
en-wikipedia-org-3485	978	8	in	in	IN
en-wikipedia-org-3485	978	9	humans	human	NNS
en-wikipedia-org-3485	978	10	and	and	CC
en-wikipedia-org-3485	978	11	animals	animal	NNS
en-wikipedia-org-3485	978	12	"	"	''
en-wikipedia-org-3485	978	13	.	.	.
en-wikipedia-org-3485	979	1	Psychopharmacology	psychopharmacology	NN
en-wikipedia-org-3485	979	2	.	.	.
en-wikipedia-org-3485	980	1	199	199	CD
en-wikipedia-org-3485	980	2	(	(	-LRB-
en-wikipedia-org-3485	980	3	3	3	CD
en-wikipedia-org-3485	980	4	)	)	-RRB-
en-wikipedia-org-3485	980	5	:	:	:
en-wikipedia-org-3485	980	6	457–480	457–480	CD
en-wikipedia-org-3485	980	7	.	.	.
en-wikipedia-org-3485	981	1	doi:10.1007	doi:10.1007	VB
en-wikipedia-org-3485	981	2	/	/	SYM
en-wikipedia-org-3485	981	3	s00213	s00213	NNP
en-wikipedia-org-3485	981	4	-	-	HYPH
en-wikipedia-org-3485	981	5	008	008	CD
en-wikipedia-org-3485	981	6	-	-	HYPH
en-wikipedia-org-3485	981	7	1099	1099	CD
en-wikipedia-org-3485	981	8	-	-	SYM
en-wikipedia-org-3485	981	9	6	6	CD
en-wikipedia-org-3485	981	10	.	.	.
en-wikipedia-org-3485	982	1	PMC	PMC	NNP
en-wikipedia-org-3485	982	2	 	  	_SP
en-wikipedia-org-3485	982	3	3004012	3004012	CD
en-wikipedia-org-3485	982	4	.	.	.
en-wikipedia-org-3485	983	1	PMID	PMID	NNP
en-wikipedia-org-3485	983	2	 	  	_SP
en-wikipedia-org-3485	983	3	18311558	18311558	CD
en-wikipedia-org-3485	983	4	.	.	.
en-wikipedia-org-3485	984	1	^	^	NNP
en-wikipedia-org-3485	984	2	a	a	DT
en-wikipedia-org-3485	984	3	b	b	NNP
en-wikipedia-org-3485	984	4	Ferreri	Ferreri	NNP
en-wikipedia-org-3485	984	5	L	L	NNP
en-wikipedia-org-3485	984	6	,	,	,
en-wikipedia-org-3485	984	7	Mas	Mas	NNP
en-wikipedia-org-3485	984	8	-	-	HYPH
en-wikipedia-org-3485	984	9	Herrero	Herrero	NNP
en-wikipedia-org-3485	984	10	E	E	NNP
en-wikipedia-org-3485	984	11	,	,	,
en-wikipedia-org-3485	984	12	Zatorre	Zatorre	NNP
en-wikipedia-org-3485	984	13	RJ	RJ	NNP
en-wikipedia-org-3485	984	14	,	,	,
en-wikipedia-org-3485	984	15	Ripollés	Ripollés	NNP
en-wikipedia-org-3485	984	16	P	P	NNP
en-wikipedia-org-3485	984	17	,	,	,
en-wikipedia-org-3485	984	18	Gomez	Gomez	NNP
en-wikipedia-org-3485	984	19	-	-	HYPH
en-wikipedia-org-3485	984	20	Andres	Andres	NNP
en-wikipedia-org-3485	984	21	A	A	NNP
en-wikipedia-org-3485	984	22	,	,	,
en-wikipedia-org-3485	984	23	Alicart	Alicart	NNP
en-wikipedia-org-3485	984	24	H	H	NNP
en-wikipedia-org-3485	984	25	,	,	,
en-wikipedia-org-3485	984	26	Olivé	Olivé	NNP
en-wikipedia-org-3485	984	27	G	G	NNP
en-wikipedia-org-3485	984	28	,	,	,
en-wikipedia-org-3485	984	29	Marco	Marco	NNP
en-wikipedia-org-3485	984	30	-	-	HYPH
en-wikipedia-org-3485	984	31	Pallarés	Pallarés	NNP
en-wikipedia-org-3485	984	32	J	J	NNP
en-wikipedia-org-3485	984	33	,	,	,
en-wikipedia-org-3485	984	34	Antonijoan	Antonijoan	NNP
en-wikipedia-org-3485	984	35	RM	RM	NNP
en-wikipedia-org-3485	984	36	,	,	,
en-wikipedia-org-3485	984	37	Valle	Valle	NNP
en-wikipedia-org-3485	984	38	M	M	NNP
en-wikipedia-org-3485	984	39	,	,	,
en-wikipedia-org-3485	984	40	Riba	Riba	NNP
en-wikipedia-org-3485	984	41	J	J	NNP
en-wikipedia-org-3485	984	42	,	,	,
en-wikipedia-org-3485	984	43	Rodriguez	Rodriguez	NNP
en-wikipedia-org-3485	984	44	-	-	HYPH
en-wikipedia-org-3485	984	45	Fornells	fornell	VBZ
en-wikipedia-org-3485	984	46	A	a	NN
en-wikipedia-org-3485	984	47	(	(	-LRB-
en-wikipedia-org-3485	984	48	January	January	NNP
en-wikipedia-org-3485	984	49	2019	2019	CD
en-wikipedia-org-3485	984	50	)	)	-RRB-
en-wikipedia-org-3485	984	51	.	.	.
en-wikipedia-org-3485	985	1	"	"	``
en-wikipedia-org-3485	985	2	Dopamine	dopamine	NN
en-wikipedia-org-3485	985	3	modulates	modulate	VBZ
en-wikipedia-org-3485	985	4	the	the	DT
en-wikipedia-org-3485	985	5	reward	reward	NN
en-wikipedia-org-3485	985	6	experiences	experience	NNS
en-wikipedia-org-3485	985	7	elicited	elicit	VBN
en-wikipedia-org-3485	985	8	by	by	IN
en-wikipedia-org-3485	985	9	music	music	NN
en-wikipedia-org-3485	985	10	"	"	''
en-wikipedia-org-3485	985	11	.	.	.
en-wikipedia-org-3485	986	1	Proceedings	proceeding	NNS
en-wikipedia-org-3485	986	2	of	of	IN
en-wikipedia-org-3485	986	3	the	the	DT
en-wikipedia-org-3485	986	4	National	National	NNP
en-wikipedia-org-3485	986	5	Academy	Academy	NNP
en-wikipedia-org-3485	986	6	of	of	IN
en-wikipedia-org-3485	986	7	Sciences	Sciences	NNPS
en-wikipedia-org-3485	986	8	of	of	IN
en-wikipedia-org-3485	986	9	the	the	DT
en-wikipedia-org-3485	986	10	United	United	NNP
en-wikipedia-org-3485	986	11	States	States	NNP
en-wikipedia-org-3485	986	12	of	of	IN
en-wikipedia-org-3485	986	13	America	America	NNP
en-wikipedia-org-3485	986	14	.	.	.
en-wikipedia-org-3485	987	1	116	116	CD
en-wikipedia-org-3485	987	2	(	(	-LRB-
en-wikipedia-org-3485	987	3	9	9	CD
en-wikipedia-org-3485	987	4	)	)	-RRB-
en-wikipedia-org-3485	987	5	:	:	:
en-wikipedia-org-3485	987	6	3793–3798	3793–3798	CD
en-wikipedia-org-3485	987	7	.	.	.
en-wikipedia-org-3485	988	1	doi:10.1073	doi:10.1073	NNP
en-wikipedia-org-3485	988	2	/	/	SYM
en-wikipedia-org-3485	988	3	pnas.1811878116	pnas.1811878116	NNP
en-wikipedia-org-3485	988	4	.	.	.
en-wikipedia-org-3485	989	1	PMC	PMC	NNP
en-wikipedia-org-3485	989	2	 	  	_SP
en-wikipedia-org-3485	989	3	6397525	6397525	CD
en-wikipedia-org-3485	989	4	.	.	.
en-wikipedia-org-3485	990	1	PMID	PMID	NNP
en-wikipedia-org-3485	990	2	 	  	_SP
en-wikipedia-org-3485	990	3	30670642	30670642	CD
en-wikipedia-org-3485	990	4	.	.	.
en-wikipedia-org-3485	991	1	Lay	Lay	NNP
en-wikipedia-org-3485	991	2	summary	summary	NN
en-wikipedia-org-3485	991	3	–	–	:
en-wikipedia-org-3485	991	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	991	5	News	News	NNP
en-wikipedia-org-3485	991	6	(	(	-LRB-
en-wikipedia-org-3485	991	7	24	24	CD
en-wikipedia-org-3485	991	8	January	January	NNP
en-wikipedia-org-3485	991	9	2019	2019	CD
en-wikipedia-org-3485	991	10	)	)	-RRB-
en-wikipedia-org-3485	991	11	.	.	.
en-wikipedia-org-3485	992	1	Listening	listen	VBG
en-wikipedia-org-3485	992	2	to	to	TO
en-wikipedia-org-3485	992	3	pleasurable	pleasurable	JJ
en-wikipedia-org-3485	992	4	music	music	NN
en-wikipedia-org-3485	992	5	is	be	VBZ
en-wikipedia-org-3485	992	6	often	often	RB
en-wikipedia-org-3485	992	7	accompanied	accompany	VBN
en-wikipedia-org-3485	992	8	by	by	IN
en-wikipedia-org-3485	992	9	measurable	measurable	JJ
en-wikipedia-org-3485	992	10	bodily	bodily	JJ
en-wikipedia-org-3485	992	11	reactions	reaction	NNS
en-wikipedia-org-3485	992	12	such	such	JJ
en-wikipedia-org-3485	992	13	as	as	IN
en-wikipedia-org-3485	992	14	goose	goose	JJ
en-wikipedia-org-3485	992	15	bumps	bump	NNS
en-wikipedia-org-3485	992	16	or	or	CC
en-wikipedia-org-3485	992	17	shivers	shiver	NNS
en-wikipedia-org-3485	992	18	down	down	IN
en-wikipedia-org-3485	992	19	the	the	DT
en-wikipedia-org-3485	992	20	spine	spine	NN
en-wikipedia-org-3485	992	21	,	,	,
en-wikipedia-org-3485	992	22	commonly	commonly	RB
en-wikipedia-org-3485	992	23	called	call	VBN
en-wikipedia-org-3485	992	24	“	"	``
en-wikipedia-org-3485	992	25	chills	chill	NNS
en-wikipedia-org-3485	992	26	”	"	''
en-wikipedia-org-3485	992	27	or	or	CC
en-wikipedia-org-3485	992	28	“	"	``
en-wikipedia-org-3485	992	29	frissons	frisson	NNS
en-wikipedia-org-3485	992	30	.	.	.
en-wikipedia-org-3485	992	31	”	"	''
en-wikipedia-org-3485	992	32	 	  	_SP
en-wikipedia-org-3485	992	33	...	...	.
en-wikipedia-org-3485	993	1	Overall	overall	RB
en-wikipedia-org-3485	993	2	,	,	,
en-wikipedia-org-3485	993	3	our	-PRON-	PRP$
en-wikipedia-org-3485	993	4	results	result	NNS
en-wikipedia-org-3485	993	5	straightforwardly	straightforwardly	RB
en-wikipedia-org-3485	993	6	revealed	reveal	VBD
en-wikipedia-org-3485	993	7	that	that	IN
en-wikipedia-org-3485	993	8	pharmacological	pharmacological	JJ
en-wikipedia-org-3485	993	9	interventions	intervention	NNS
en-wikipedia-org-3485	993	10	bidirectionally	bidirectionally	RB
en-wikipedia-org-3485	993	11	modulated	modulate	VBD
en-wikipedia-org-3485	993	12	the	the	DT
en-wikipedia-org-3485	993	13	reward	reward	NN
en-wikipedia-org-3485	993	14	responses	response	NNS
en-wikipedia-org-3485	993	15	elicited	elicit	VBN
en-wikipedia-org-3485	993	16	by	by	IN
en-wikipedia-org-3485	993	17	music	music	NN
en-wikipedia-org-3485	993	18	.	.	.
en-wikipedia-org-3485	994	1	In	in	IN
en-wikipedia-org-3485	994	2	particular	particular	JJ
en-wikipedia-org-3485	994	3	,	,	,
en-wikipedia-org-3485	994	4	we	-PRON-	PRP
en-wikipedia-org-3485	994	5	found	find	VBD
en-wikipedia-org-3485	994	6	that	that	IN
en-wikipedia-org-3485	994	7	risperidone	risperidone	NN
en-wikipedia-org-3485	994	8	impaired	impair	VBN
en-wikipedia-org-3485	994	9	participants	participant	NNS
en-wikipedia-org-3485	994	10	’	’	POS
en-wikipedia-org-3485	994	11	ability	ability	NN
en-wikipedia-org-3485	994	12	to	to	TO
en-wikipedia-org-3485	994	13	experience	experience	VB
en-wikipedia-org-3485	994	14	musical	musical	JJ
en-wikipedia-org-3485	994	15	pleasure	pleasure	NN
en-wikipedia-org-3485	994	16	,	,	,
en-wikipedia-org-3485	994	17	whereas	whereas	IN
en-wikipedia-org-3485	994	18	levodopa	levodopa	NN
en-wikipedia-org-3485	994	19	enhanced	enhance	VBD
en-wikipedia-org-3485	994	20	it	-PRON-	PRP
en-wikipedia-org-3485	994	21	.	.	.
en-wikipedia-org-3485	995	1	...	...	NFP
en-wikipedia-org-3485	996	1	Here	here	RB
en-wikipedia-org-3485	996	2	,	,	,
en-wikipedia-org-3485	996	3	in	in	IN
en-wikipedia-org-3485	996	4	contrast	contrast	NN
en-wikipedia-org-3485	996	5	,	,	,
en-wikipedia-org-3485	996	6	studying	study	VBG
en-wikipedia-org-3485	996	7	responses	response	NNS
en-wikipedia-org-3485	996	8	to	to	IN
en-wikipedia-org-3485	996	9	abstract	abstract	JJ
en-wikipedia-org-3485	996	10	rewards	reward	NNS
en-wikipedia-org-3485	996	11	in	in	IN
en-wikipedia-org-3485	996	12	human	human	JJ
en-wikipedia-org-3485	996	13	subjects	subject	NNS
en-wikipedia-org-3485	996	14	,	,	,
en-wikipedia-org-3485	996	15	we	-PRON-	PRP
en-wikipedia-org-3485	996	16	show	show	VBP
en-wikipedia-org-3485	996	17	that	that	IN
en-wikipedia-org-3485	996	18	manipulation	manipulation	NN
en-wikipedia-org-3485	996	19	of	of	IN
en-wikipedia-org-3485	996	20	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	996	21	transmission	transmission	NN
en-wikipedia-org-3485	996	22	affects	affect	VBZ
en-wikipedia-org-3485	996	23	both	both	DT
en-wikipedia-org-3485	996	24	the	the	DT
en-wikipedia-org-3485	996	25	pleasure	pleasure	NN
en-wikipedia-org-3485	996	26	(	(	-LRB-
en-wikipedia-org-3485	996	27	i.e.	i.e.	FW
en-wikipedia-org-3485	996	28	,	,	,
en-wikipedia-org-3485	996	29	amount	amount	NN
en-wikipedia-org-3485	996	30	of	of	IN
en-wikipedia-org-3485	996	31	time	time	NN
en-wikipedia-org-3485	996	32	reporting	reporting	NN
en-wikipedia-org-3485	996	33	chills	chill	NNS
en-wikipedia-org-3485	996	34	and	and	CC
en-wikipedia-org-3485	996	35	emotional	emotional	JJ
en-wikipedia-org-3485	996	36	arousal	arousal	NN
en-wikipedia-org-3485	996	37	measured	measure	VBN
en-wikipedia-org-3485	996	38	by	by	IN
en-wikipedia-org-3485	996	39	EDA	EDA	NNP
en-wikipedia-org-3485	996	40	)	)	-RRB-
en-wikipedia-org-3485	996	41	and	and	CC
en-wikipedia-org-3485	996	42	the	the	DT
en-wikipedia-org-3485	996	43	motivational	motivational	JJ
en-wikipedia-org-3485	996	44	components	component	NNS
en-wikipedia-org-3485	996	45	of	of	IN
en-wikipedia-org-3485	996	46	musical	musical	JJ
en-wikipedia-org-3485	996	47	reward	reward	NN
en-wikipedia-org-3485	996	48	(	(	-LRB-
en-wikipedia-org-3485	996	49	money	money	NN
en-wikipedia-org-3485	996	50	willing	willing	JJ
en-wikipedia-org-3485	996	51	to	to	TO
en-wikipedia-org-3485	996	52	spend	spend	VB
en-wikipedia-org-3485	996	53	)	)	-RRB-
en-wikipedia-org-3485	996	54	.	.	.
en-wikipedia-org-3485	997	1	These	these	DT
en-wikipedia-org-3485	997	2	findings	finding	NNS
en-wikipedia-org-3485	997	3	suggest	suggest	VBP
en-wikipedia-org-3485	997	4	that	that	IN
en-wikipedia-org-3485	997	5	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	997	6	signaling	signaling	NN
en-wikipedia-org-3485	997	7	is	be	VBZ
en-wikipedia-org-3485	997	8	a	a	DT
en-wikipedia-org-3485	997	9	sine	sine	JJ
en-wikipedia-org-3485	997	10	qua	qua	NN
en-wikipedia-org-3485	997	11	non	non	JJ
en-wikipedia-org-3485	997	12	condition	condition	NN
en-wikipedia-org-3485	997	13	not	not	RB
en-wikipedia-org-3485	997	14	only	only	RB
en-wikipedia-org-3485	997	15	for	for	IN
en-wikipedia-org-3485	997	16	motivational	motivational	JJ
en-wikipedia-org-3485	997	17	responses	response	NNS
en-wikipedia-org-3485	997	18	,	,	,
en-wikipedia-org-3485	997	19	as	as	IN
en-wikipedia-org-3485	997	20	has	have	VBZ
en-wikipedia-org-3485	997	21	been	be	VBN
en-wikipedia-org-3485	997	22	shown	show	VBN
en-wikipedia-org-3485	997	23	with	with	IN
en-wikipedia-org-3485	997	24	primary	primary	JJ
en-wikipedia-org-3485	997	25	and	and	CC
en-wikipedia-org-3485	997	26	secondary	secondary	JJ
en-wikipedia-org-3485	997	27	rewards	reward	NNS
en-wikipedia-org-3485	997	28	,	,	,
en-wikipedia-org-3485	997	29	but	but	CC
en-wikipedia-org-3485	997	30	also	also	RB
en-wikipedia-org-3485	997	31	for	for	IN
en-wikipedia-org-3485	997	32	hedonic	hedonic	JJ
en-wikipedia-org-3485	997	33	reactions	reaction	NNS
en-wikipedia-org-3485	997	34	to	to	IN
en-wikipedia-org-3485	997	35	music	music	NN
en-wikipedia-org-3485	997	36	.	.	.
en-wikipedia-org-3485	998	1	This	this	DT
en-wikipedia-org-3485	998	2	result	result	NN
en-wikipedia-org-3485	998	3	supports	support	VBZ
en-wikipedia-org-3485	998	4	recent	recent	JJ
en-wikipedia-org-3485	998	5	findings	finding	NNS
en-wikipedia-org-3485	998	6	showing	show	VBG
en-wikipedia-org-3485	998	7	that	that	DT
en-wikipedia-org-3485	998	8	dopamine	dopamine	NN
en-wikipedia-org-3485	998	9	also	also	RB
en-wikipedia-org-3485	998	10	mediates	mediate	VBZ
en-wikipedia-org-3485	998	11	the	the	DT
en-wikipedia-org-3485	998	12	perceived	perceived	JJ
en-wikipedia-org-3485	998	13	pleasantness	pleasantness	NN
en-wikipedia-org-3485	998	14	attained	attain	VBN
en-wikipedia-org-3485	998	15	by	by	IN
en-wikipedia-org-3485	998	16	other	other	JJ
en-wikipedia-org-3485	998	17	types	type	NNS
en-wikipedia-org-3485	998	18	of	of	IN
en-wikipedia-org-3485	998	19	abstract	abstract	JJ
en-wikipedia-org-3485	998	20	rewards	reward	NNS
en-wikipedia-org-3485	998	21	(	(	-LRB-
en-wikipedia-org-3485	998	22	37	37	CD
en-wikipedia-org-3485	998	23	)	)	-RRB-
en-wikipedia-org-3485	998	24	and	and	CC
en-wikipedia-org-3485	998	25	challenges	challenge	VBZ
en-wikipedia-org-3485	998	26	previous	previous	JJ
en-wikipedia-org-3485	998	27	findings	finding	NNS
en-wikipedia-org-3485	998	28	in	in	IN
en-wikipedia-org-3485	998	29	animal	animal	NN
en-wikipedia-org-3485	998	30	models	model	NNS
en-wikipedia-org-3485	998	31	on	on	IN
en-wikipedia-org-3485	998	32	primary	primary	JJ
en-wikipedia-org-3485	998	33	rewards	reward	NNS
en-wikipedia-org-3485	998	34	,	,	,
en-wikipedia-org-3485	998	35	such	such	JJ
en-wikipedia-org-3485	998	36	as	as	IN
en-wikipedia-org-3485	998	37	food	food	NN
en-wikipedia-org-3485	998	38	(	(	-LRB-
en-wikipedia-org-3485	998	39	42	42	CD
en-wikipedia-org-3485	998	40	,	,	,
en-wikipedia-org-3485	998	41	43	43	CD
en-wikipedia-org-3485	998	42	)	)	-RRB-
en-wikipedia-org-3485	998	43	.	.	.
en-wikipedia-org-3485	999	1	^	^	NNP
en-wikipedia-org-3485	999	2	a	a	DT
en-wikipedia-org-3485	999	3	b	b	NNP
en-wikipedia-org-3485	999	4	Goupil	Goupil	NNP
en-wikipedia-org-3485	999	5	L	L	NNP
en-wikipedia-org-3485	999	6	,	,	,
en-wikipedia-org-3485	999	7	Aucouturier	Aucouturier	NNP
en-wikipedia-org-3485	999	8	JJ	JJ	NNP
en-wikipedia-org-3485	999	9	(	(	-LRB-
en-wikipedia-org-3485	999	10	February	February	NNP
en-wikipedia-org-3485	999	11	2019	2019	CD
en-wikipedia-org-3485	999	12	)	)	-RRB-
en-wikipedia-org-3485	999	13	.	.	.
en-wikipedia-org-3485	1000	1	"	"	``
en-wikipedia-org-3485	1000	2	Musical	musical	JJ
en-wikipedia-org-3485	1000	3	pleasure	pleasure	NN
en-wikipedia-org-3485	1000	4	and	and	CC
en-wikipedia-org-3485	1000	5	musical	musical	JJ
en-wikipedia-org-3485	1000	6	emotions	emotion	NNS
en-wikipedia-org-3485	1000	7	"	"	''
en-wikipedia-org-3485	1000	8	.	.	.
en-wikipedia-org-3485	1001	1	Proceedings	proceeding	NNS
en-wikipedia-org-3485	1001	2	of	of	IN
en-wikipedia-org-3485	1001	3	the	the	DT
en-wikipedia-org-3485	1001	4	National	National	NNP
en-wikipedia-org-3485	1001	5	Academy	Academy	NNP
en-wikipedia-org-3485	1001	6	of	of	IN
en-wikipedia-org-3485	1001	7	Sciences	Sciences	NNPS
en-wikipedia-org-3485	1001	8	of	of	IN
en-wikipedia-org-3485	1001	9	the	the	DT
en-wikipedia-org-3485	1001	10	United	United	NNP
en-wikipedia-org-3485	1001	11	States	States	NNP
en-wikipedia-org-3485	1001	12	of	of	IN
en-wikipedia-org-3485	1001	13	America	America	NNP
en-wikipedia-org-3485	1001	14	.	.	.
en-wikipedia-org-3485	1002	1	116	116	CD
en-wikipedia-org-3485	1002	2	(	(	-LRB-
en-wikipedia-org-3485	1002	3	9	9	CD
en-wikipedia-org-3485	1002	4	)	)	-RRB-
en-wikipedia-org-3485	1002	5	:	:	:
en-wikipedia-org-3485	1002	6	3364–3366	3364–3366	CD
en-wikipedia-org-3485	1002	7	.	.	.
en-wikipedia-org-3485	1003	1	doi:10.1073	doi:10.1073	NNP
en-wikipedia-org-3485	1003	2	/	/	SYM
en-wikipedia-org-3485	1003	3	pnas.1900369116	pnas.1900369116	NNP
en-wikipedia-org-3485	1003	4	.	.	.
en-wikipedia-org-3485	1004	1	PMC	PMC	NNP
en-wikipedia-org-3485	1004	2	 	  	_SP
en-wikipedia-org-3485	1004	3	6397567	6397567	CD
en-wikipedia-org-3485	1004	4	.	.	.
en-wikipedia-org-3485	1005	1	PMID	PMID	NNP
en-wikipedia-org-3485	1005	2	 	  	_SP
en-wikipedia-org-3485	1005	3	30770455	30770455	CD
en-wikipedia-org-3485	1005	4	.	.	.
en-wikipedia-org-3485	1006	1	In	in	IN
en-wikipedia-org-3485	1006	2	a	a	DT
en-wikipedia-org-3485	1006	3	pharmacological	pharmacological	JJ
en-wikipedia-org-3485	1006	4	study	study	NN
en-wikipedia-org-3485	1006	5	published	publish	VBN
en-wikipedia-org-3485	1006	6	in	in	IN
en-wikipedia-org-3485	1006	7	PNAS	PNAS	NNP
en-wikipedia-org-3485	1006	8	,	,	,
en-wikipedia-org-3485	1006	9	Ferreri	Ferreri	NNP
en-wikipedia-org-3485	1006	10	et	et	FW
en-wikipedia-org-3485	1006	11	al	al	NNP
en-wikipedia-org-3485	1006	12	.	.	.
en-wikipedia-org-3485	1007	1	(	(	-LRB-
en-wikipedia-org-3485	1007	2	1	1	LS
en-wikipedia-org-3485	1007	3	)	)	-RRB-
en-wikipedia-org-3485	1007	4	present	present	JJ
en-wikipedia-org-3485	1007	5	evidence	evidence	NN
en-wikipedia-org-3485	1007	6	that	that	IN
en-wikipedia-org-3485	1007	7	enhancing	enhance	VBG
en-wikipedia-org-3485	1007	8	or	or	CC
en-wikipedia-org-3485	1007	9	inhibiting	inhibit	VBG
en-wikipedia-org-3485	1007	10	dopamine	dopamine	NN
en-wikipedia-org-3485	1007	11	signaling	signaling	NN
en-wikipedia-org-3485	1007	12	using	use	VBG
en-wikipedia-org-3485	1007	13	levodopa	levodopa	NN
en-wikipedia-org-3485	1007	14	or	or	CC
en-wikipedia-org-3485	1007	15	risperidone	risperidone	NN
en-wikipedia-org-3485	1007	16	modulates	modulate	VBZ
en-wikipedia-org-3485	1007	17	the	the	DT
en-wikipedia-org-3485	1007	18	pleasure	pleasure	NN
en-wikipedia-org-3485	1007	19	experienced	experience	VBN
en-wikipedia-org-3485	1007	20	while	while	IN
en-wikipedia-org-3485	1007	21	listening	listen	VBG
en-wikipedia-org-3485	1007	22	to	to	IN
en-wikipedia-org-3485	1007	23	music	music	NN
en-wikipedia-org-3485	1007	24	.	.	.
en-wikipedia-org-3485	1008	1	...	...	NFP
en-wikipedia-org-3485	1009	1	In	in	IN
en-wikipedia-org-3485	1009	2	a	a	DT
en-wikipedia-org-3485	1009	3	final	final	JJ
en-wikipedia-org-3485	1009	4	salvo	salvo	NN
en-wikipedia-org-3485	1009	5	to	to	TO
en-wikipedia-org-3485	1009	6	establish	establish	VB
en-wikipedia-org-3485	1009	7	not	not	RB
en-wikipedia-org-3485	1009	8	only	only	RB
en-wikipedia-org-3485	1009	9	the	the	DT
en-wikipedia-org-3485	1009	10	correlational	correlational	JJ
en-wikipedia-org-3485	1009	11	but	but	CC
en-wikipedia-org-3485	1009	12	also	also	RB
en-wikipedia-org-3485	1009	13	the	the	DT
en-wikipedia-org-3485	1009	14	causal	causal	JJ
en-wikipedia-org-3485	1009	15	implication	implication	NN
en-wikipedia-org-3485	1009	16	of	of	IN
en-wikipedia-org-3485	1009	17	dopamine	dopamine	NN
en-wikipedia-org-3485	1009	18	in	in	IN
en-wikipedia-org-3485	1009	19	musical	musical	JJ
en-wikipedia-org-3485	1009	20	pleasure	pleasure	NN
en-wikipedia-org-3485	1009	21	,	,	,
en-wikipedia-org-3485	1009	22	the	the	DT
en-wikipedia-org-3485	1009	23	authors	author	NNS
en-wikipedia-org-3485	1009	24	have	have	VBP
en-wikipedia-org-3485	1009	25	turned	turn	VBN
en-wikipedia-org-3485	1009	26	to	to	IN
en-wikipedia-org-3485	1009	27	directly	directly	RB
en-wikipedia-org-3485	1009	28	manipulating	manipulate	VBG
en-wikipedia-org-3485	1009	29	dopaminergic	dopaminergic	JJ
en-wikipedia-org-3485	1009	30	signaling	signaling	NN
en-wikipedia-org-3485	1009	31	in	in	IN
en-wikipedia-org-3485	1009	32	the	the	DT
en-wikipedia-org-3485	1009	33	striatum	striatum	NN
en-wikipedia-org-3485	1009	34	,	,	,
en-wikipedia-org-3485	1009	35	first	first	RB
en-wikipedia-org-3485	1009	36	by	by	IN
en-wikipedia-org-3485	1009	37	applying	apply	VBG
en-wikipedia-org-3485	1009	38	excitatory	excitatory	NN
en-wikipedia-org-3485	1009	39	and	and	CC
en-wikipedia-org-3485	1009	40	inhibitory	inhibitory	NN
en-wikipedia-org-3485	1009	41	transcranial	transcranial	JJ
en-wikipedia-org-3485	1009	42	magnetic	magnetic	JJ
en-wikipedia-org-3485	1009	43	stimulation	stimulation	NN
en-wikipedia-org-3485	1009	44	over	over	IN
en-wikipedia-org-3485	1009	45	their	-PRON-	PRP$
en-wikipedia-org-3485	1009	46	participants	participant	NNS
en-wikipedia-org-3485	1009	47	’	'	''
en-wikipedia-org-3485	1009	48	left	leave	VBD
en-wikipedia-org-3485	1009	49	dorsolateral	dorsolateral	JJ
en-wikipedia-org-3485	1009	50	prefrontal	prefrontal	NNP
en-wikipedia-org-3485	1009	51	cortex	cortex	NNP
en-wikipedia-org-3485	1009	52	,	,	,
en-wikipedia-org-3485	1009	53	a	a	DT
en-wikipedia-org-3485	1009	54	region	region	NN
en-wikipedia-org-3485	1009	55	known	know	VBN
en-wikipedia-org-3485	1009	56	to	to	TO
en-wikipedia-org-3485	1009	57	modulate	modulate	VB
en-wikipedia-org-3485	1009	58	striatal	striatal	JJ
en-wikipedia-org-3485	1009	59	function	function	NN
en-wikipedia-org-3485	1009	60	(	(	-LRB-
en-wikipedia-org-3485	1009	61	5	5	CD
en-wikipedia-org-3485	1009	62	)	)	-RRB-
en-wikipedia-org-3485	1009	63	,	,	,
en-wikipedia-org-3485	1009	64	and	and	CC
en-wikipedia-org-3485	1009	65	finally	finally	RB
en-wikipedia-org-3485	1009	66	,	,	,
en-wikipedia-org-3485	1009	67	in	in	IN
en-wikipedia-org-3485	1009	68	the	the	DT
en-wikipedia-org-3485	1009	69	current	current	JJ
en-wikipedia-org-3485	1009	70	study	study	NN
en-wikipedia-org-3485	1009	71	,	,	,
en-wikipedia-org-3485	1009	72	by	by	IN
en-wikipedia-org-3485	1009	73	administrating	administrate	VBG
en-wikipedia-org-3485	1009	74	pharmaceutical	pharmaceutical	JJ
en-wikipedia-org-3485	1009	75	agents	agent	NNS
en-wikipedia-org-3485	1009	76	able	able	JJ
en-wikipedia-org-3485	1009	77	to	to	TO
en-wikipedia-org-3485	1009	78	alter	alter	VB
en-wikipedia-org-3485	1009	79	dopamine	dopamine	VB
en-wikipedia-org-3485	1009	80	synaptic	synaptic	JJ
en-wikipedia-org-3485	1009	81	availability	availability	NN
en-wikipedia-org-3485	1009	82	(	(	-LRB-
en-wikipedia-org-3485	1009	83	1	1	CD
en-wikipedia-org-3485	1009	84	)	)	-RRB-
en-wikipedia-org-3485	1009	85	,	,	,
en-wikipedia-org-3485	1009	86	both	both	DT
en-wikipedia-org-3485	1009	87	of	of	IN
en-wikipedia-org-3485	1009	88	which	which	WDT
en-wikipedia-org-3485	1009	89	influenced	influence	VBD
en-wikipedia-org-3485	1009	90	perceived	perceive	VBN
en-wikipedia-org-3485	1009	91	pleasure	pleasure	NN
en-wikipedia-org-3485	1009	92	,	,	,
en-wikipedia-org-3485	1009	93	physiological	physiological	JJ
en-wikipedia-org-3485	1009	94	measures	measure	NNS
en-wikipedia-org-3485	1009	95	of	of	IN
en-wikipedia-org-3485	1009	96	arousal	arousal	NN
en-wikipedia-org-3485	1009	97	,	,	,
en-wikipedia-org-3485	1009	98	and	and	CC
en-wikipedia-org-3485	1009	99	the	the	DT
en-wikipedia-org-3485	1009	100	monetary	monetary	JJ
en-wikipedia-org-3485	1009	101	value	value	NN
en-wikipedia-org-3485	1009	102	assigned	assign	VBN
en-wikipedia-org-3485	1009	103	to	to	IN
en-wikipedia-org-3485	1009	104	music	music	NN
en-wikipedia-org-3485	1009	105	in	in	IN
en-wikipedia-org-3485	1009	106	the	the	DT
en-wikipedia-org-3485	1009	107	predicted	predict	VBN
en-wikipedia-org-3485	1009	108	direction	direction	NN
en-wikipedia-org-3485	1009	109	.	.	.
en-wikipedia-org-3485	1010	1	...	...	NFP
en-wikipedia-org-3485	1011	1	While	while	IN
en-wikipedia-org-3485	1011	2	the	the	DT
en-wikipedia-org-3485	1011	3	question	question	NN
en-wikipedia-org-3485	1011	4	of	of	IN
en-wikipedia-org-3485	1011	5	the	the	DT
en-wikipedia-org-3485	1011	6	musical	musical	JJ
en-wikipedia-org-3485	1011	7	expression	expression	NN
en-wikipedia-org-3485	1011	8	of	of	IN
en-wikipedia-org-3485	1011	9	emotion	emotion	NN
en-wikipedia-org-3485	1011	10	has	have	VBZ
en-wikipedia-org-3485	1011	11	a	a	DT
en-wikipedia-org-3485	1011	12	long	long	JJ
en-wikipedia-org-3485	1011	13	history	history	NN
en-wikipedia-org-3485	1011	14	of	of	IN
en-wikipedia-org-3485	1011	15	investigation	investigation	NN
en-wikipedia-org-3485	1011	16	,	,	,
en-wikipedia-org-3485	1011	17	including	include	VBG
en-wikipedia-org-3485	1011	18	in	in	IN
en-wikipedia-org-3485	1011	19	PNAS	PNAS	NNP
en-wikipedia-org-3485	1011	20	(	(	-LRB-
en-wikipedia-org-3485	1011	21	6	6	CD
en-wikipedia-org-3485	1011	22	)	)	-RRB-
en-wikipedia-org-3485	1011	23	,	,	,
en-wikipedia-org-3485	1011	24	and	and	CC
en-wikipedia-org-3485	1011	25	the	the	DT
en-wikipedia-org-3485	1011	26	1990s	1990s	CD
en-wikipedia-org-3485	1011	27	psychophysiological	psychophysiological	NNP
en-wikipedia-org-3485	1011	28	strand	strand	NN
en-wikipedia-org-3485	1011	29	of	of	IN
en-wikipedia-org-3485	1011	30	research	research	NN
en-wikipedia-org-3485	1011	31	had	have	VBD
en-wikipedia-org-3485	1011	32	already	already	RB
en-wikipedia-org-3485	1011	33	established	establish	VBN
en-wikipedia-org-3485	1011	34	that	that	DT
en-wikipedia-org-3485	1011	35	musical	musical	JJ
en-wikipedia-org-3485	1011	36	pleasure	pleasure	NN
en-wikipedia-org-3485	1011	37	could	could	MD
en-wikipedia-org-3485	1011	38	activate	activate	VB
en-wikipedia-org-3485	1011	39	the	the	DT
en-wikipedia-org-3485	1011	40	autonomic	autonomic	JJ
en-wikipedia-org-3485	1011	41	nervous	nervous	JJ
en-wikipedia-org-3485	1011	42	system	system	NN
en-wikipedia-org-3485	1011	43	(	(	-LRB-
en-wikipedia-org-3485	1011	44	7	7	CD
en-wikipedia-org-3485	1011	45	)	)	-RRB-
en-wikipedia-org-3485	1011	46	,	,	,
en-wikipedia-org-3485	1011	47	the	the	DT
en-wikipedia-org-3485	1011	48	authors	author	NNS
en-wikipedia-org-3485	1011	49	’	’	POS
en-wikipedia-org-3485	1011	50	demonstration	demonstration	NN
en-wikipedia-org-3485	1011	51	of	of	IN
en-wikipedia-org-3485	1011	52	the	the	DT
en-wikipedia-org-3485	1011	53	implication	implication	NN
en-wikipedia-org-3485	1011	54	of	of	IN
en-wikipedia-org-3485	1011	55	the	the	DT
en-wikipedia-org-3485	1011	56	reward	reward	NN
en-wikipedia-org-3485	1011	57	system	system	NN
en-wikipedia-org-3485	1011	58	in	in	IN
en-wikipedia-org-3485	1011	59	musical	musical	JJ
en-wikipedia-org-3485	1011	60	emotions	emotion	NNS
en-wikipedia-org-3485	1011	61	was	be	VBD
en-wikipedia-org-3485	1011	62	taken	take	VBN
en-wikipedia-org-3485	1011	63	as	as	IN
en-wikipedia-org-3485	1011	64	inaugural	inaugural	JJ
en-wikipedia-org-3485	1011	65	proof	proof	NN
en-wikipedia-org-3485	1011	66	that	that	IN
en-wikipedia-org-3485	1011	67	these	these	DT
en-wikipedia-org-3485	1011	68	were	be	VBD
en-wikipedia-org-3485	1011	69	veridical	veridical	JJ
en-wikipedia-org-3485	1011	70	emotions	emotion	NNS
en-wikipedia-org-3485	1011	71	whose	whose	WP$
en-wikipedia-org-3485	1011	72	study	study	NN
en-wikipedia-org-3485	1011	73	has	have	VBZ
en-wikipedia-org-3485	1011	74	full	full	JJ
en-wikipedia-org-3485	1011	75	legitimacy	legitimacy	NN
en-wikipedia-org-3485	1011	76	to	to	TO
en-wikipedia-org-3485	1011	77	inform	inform	VB
en-wikipedia-org-3485	1011	78	the	the	DT
en-wikipedia-org-3485	1011	79	neurobiology	neurobiology	NN
en-wikipedia-org-3485	1011	80	of	of	IN
en-wikipedia-org-3485	1011	81	our	-PRON-	PRP$
en-wikipedia-org-3485	1011	82	everyday	everyday	JJ
en-wikipedia-org-3485	1011	83	cognitive	cognitive	JJ
en-wikipedia-org-3485	1011	84	,	,	,
en-wikipedia-org-3485	1011	85	social	social	JJ
en-wikipedia-org-3485	1011	86	,	,	,
en-wikipedia-org-3485	1011	87	and	and	CC
en-wikipedia-org-3485	1011	88	affective	affective	JJ
en-wikipedia-org-3485	1011	89	functions	function	NNS
en-wikipedia-org-3485	1011	90	(	(	-LRB-
en-wikipedia-org-3485	1011	91	8)	8)	CD
en-wikipedia-org-3485	1011	92	.	.	.
en-wikipedia-org-3485	1012	1	Incidentally	incidentally	RB
en-wikipedia-org-3485	1012	2	,	,	,
en-wikipedia-org-3485	1012	3	this	this	DT
en-wikipedia-org-3485	1012	4	line	line	NN
en-wikipedia-org-3485	1012	5	of	of	IN
en-wikipedia-org-3485	1012	6	work	work	NN
en-wikipedia-org-3485	1012	7	,	,	,
en-wikipedia-org-3485	1012	8	culminating	culminate	VBG
en-wikipedia-org-3485	1012	9	in	in	IN
en-wikipedia-org-3485	1012	10	the	the	DT
en-wikipedia-org-3485	1012	11	article	article	NN
en-wikipedia-org-3485	1012	12	by	by	IN
en-wikipedia-org-3485	1012	13	Ferreri	Ferreri	NNP
en-wikipedia-org-3485	1012	14	et	et	FW
en-wikipedia-org-3485	1012	15	al	al	NNP
en-wikipedia-org-3485	1012	16	.	.	.
en-wikipedia-org-3485	1013	1	(	(	-LRB-
en-wikipedia-org-3485	1013	2	1	1	CD
en-wikipedia-org-3485	1013	3	)	)	-RRB-
en-wikipedia-org-3485	1013	4	,	,	,
en-wikipedia-org-3485	1013	5	has	have	VBZ
en-wikipedia-org-3485	1013	6	plausibly	plausibly	RB
en-wikipedia-org-3485	1013	7	done	do	VBN
en-wikipedia-org-3485	1013	8	more	more	JJR
en-wikipedia-org-3485	1013	9	to	to	TO
en-wikipedia-org-3485	1013	10	attract	attract	VB
en-wikipedia-org-3485	1013	11	research	research	NN
en-wikipedia-org-3485	1013	12	funding	funding	NN
en-wikipedia-org-3485	1013	13	for	for	IN
en-wikipedia-org-3485	1013	14	the	the	DT
en-wikipedia-org-3485	1013	15	field	field	NN
en-wikipedia-org-3485	1013	16	of	of	IN
en-wikipedia-org-3485	1013	17	music	music	NN
en-wikipedia-org-3485	1013	18	sciences	science	NNS
en-wikipedia-org-3485	1013	19	than	than	IN
en-wikipedia-org-3485	1013	20	any	any	DT
en-wikipedia-org-3485	1013	21	other	other	JJ
en-wikipedia-org-3485	1013	22	in	in	IN
en-wikipedia-org-3485	1013	23	this	this	DT
en-wikipedia-org-3485	1013	24	community	community	NN
en-wikipedia-org-3485	1013	25	.	.	.
en-wikipedia-org-3485	1014	1	The	the	DT
en-wikipedia-org-3485	1014	2	evidence	evidence	NN
en-wikipedia-org-3485	1014	3	of	of	IN
en-wikipedia-org-3485	1014	4	Ferreri	Ferreri	NNP
en-wikipedia-org-3485	1014	5	et	et	FW
en-wikipedia-org-3485	1014	6	al	al	NNP
en-wikipedia-org-3485	1014	7	.	.	.
en-wikipedia-org-3485	1015	1	(	(	-LRB-
en-wikipedia-org-3485	1015	2	1	1	LS
en-wikipedia-org-3485	1015	3	)	)	-RRB-
en-wikipedia-org-3485	1015	4	provides	provide	VBZ
en-wikipedia-org-3485	1015	5	the	the	DT
en-wikipedia-org-3485	1015	6	latest	late	JJS
en-wikipedia-org-3485	1015	7	support	support	NN
en-wikipedia-org-3485	1015	8	for	for	IN
en-wikipedia-org-3485	1015	9	a	a	DT
en-wikipedia-org-3485	1015	10	compelling	compelling	JJ
en-wikipedia-org-3485	1015	11	neurobiological	neurobiological	JJ
en-wikipedia-org-3485	1015	12	model	model	NN
en-wikipedia-org-3485	1015	13	in	in	IN
en-wikipedia-org-3485	1015	14	which	which	WDT
en-wikipedia-org-3485	1015	15	musical	musical	JJ
en-wikipedia-org-3485	1015	16	pleasure	pleasure	NN
en-wikipedia-org-3485	1015	17	arises	arise	VBZ
en-wikipedia-org-3485	1015	18	from	from	IN
en-wikipedia-org-3485	1015	19	the	the	DT
en-wikipedia-org-3485	1015	20	interaction	interaction	NN
en-wikipedia-org-3485	1015	21	of	of	IN
en-wikipedia-org-3485	1015	22	ancient	ancient	JJ
en-wikipedia-org-3485	1015	23	reward	reward	NN
en-wikipedia-org-3485	1015	24	/	/	SYM
en-wikipedia-org-3485	1015	25	valuation	valuation	NN
en-wikipedia-org-3485	1015	26	systems	system	NNS
en-wikipedia-org-3485	1015	27	(	(	-LRB-
en-wikipedia-org-3485	1015	28	striatal	striatal	JJ
en-wikipedia-org-3485	1015	29	–	–	:
en-wikipedia-org-3485	1015	30	limbic	limbic	JJ
en-wikipedia-org-3485	1015	31	–	–	:
en-wikipedia-org-3485	1015	32	paralimbic	paralimbic	JJ
en-wikipedia-org-3485	1015	33	)	)	-RRB-
en-wikipedia-org-3485	1015	34	with	with	IN
en-wikipedia-org-3485	1015	35	more	more	RBR
en-wikipedia-org-3485	1015	36	phylogenetically	phylogenetically	RB
en-wikipedia-org-3485	1015	37	advanced	advanced	JJ
en-wikipedia-org-3485	1015	38	perception	perception	NN
en-wikipedia-org-3485	1015	39	/	/	SYM
en-wikipedia-org-3485	1015	40	predictions	prediction	NNS
en-wikipedia-org-3485	1015	41	systems	system	NNS
en-wikipedia-org-3485	1015	42	(	(	-LRB-
en-wikipedia-org-3485	1015	43	temporofrontal	temporofrontal	JJ
en-wikipedia-org-3485	1015	44	)	)	-RRB-
en-wikipedia-org-3485	1015	45	.	.	.
en-wikipedia-org-3485	1016	1	Young	Young	NNP
en-wikipedia-org-3485	1016	2	,	,	,
en-wikipedia-org-3485	1016	3	Jared	Jared	NNP
en-wikipedia-org-3485	1016	4	W.	W.	NNP
en-wikipedia-org-3485	1016	5	;	;	:
en-wikipedia-org-3485	1016	6	Anticevic	Anticevic	NNP
en-wikipedia-org-3485	1016	7	,	,	,
en-wikipedia-org-3485	1016	8	Alan	Alan	NNP
en-wikipedia-org-3485	1016	9	;	;	:
en-wikipedia-org-3485	1016	10	Barch	Barch	NNP
en-wikipedia-org-3485	1016	11	,	,	,
en-wikipedia-org-3485	1016	12	Deanna	Deanna	NNP
en-wikipedia-org-3485	1016	13	M.	M.	NNP
en-wikipedia-org-3485	1016	14	(	(	-LRB-
en-wikipedia-org-3485	1016	15	2018	2018	CD
en-wikipedia-org-3485	1016	16	)	)	-RRB-
en-wikipedia-org-3485	1016	17	.	.	.
en-wikipedia-org-3485	1017	1	"	"	``
en-wikipedia-org-3485	1017	2	Cognitive	Cognitive	NNP
en-wikipedia-org-3485	1017	3	and	and	CC
en-wikipedia-org-3485	1017	4	Motivational	Motivational	NNP
en-wikipedia-org-3485	1017	5	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	1017	6	of	of	IN
en-wikipedia-org-3485	1017	7	Psychotic	Psychotic	NNP
en-wikipedia-org-3485	1017	8	Disorders	Disorders	NNPS
en-wikipedia-org-3485	1017	9	"	"	''
en-wikipedia-org-3485	1017	10	.	.	.
en-wikipedia-org-3485	1018	1	In	in	IN
en-wikipedia-org-3485	1018	2	Charney	Charney	NNP
en-wikipedia-org-3485	1018	3	,	,	,
en-wikipedia-org-3485	1018	4	Dennis	Dennis	NNP
en-wikipedia-org-3485	1018	5	S.	S.	NNP
en-wikipedia-org-3485	1018	6	;	;	:
en-wikipedia-org-3485	1018	7	Sklar	Sklar	NNP
en-wikipedia-org-3485	1018	8	,	,	,
en-wikipedia-org-3485	1018	9	Pamela	Pamela	NNP
en-wikipedia-org-3485	1018	10	;	;	:
en-wikipedia-org-3485	1018	11	Buxbaum	Buxbaum	NNP
en-wikipedia-org-3485	1018	12	,	,	,
en-wikipedia-org-3485	1018	13	Joseph	Joseph	NNP
en-wikipedia-org-3485	1018	14	D.	D.	NNP
en-wikipedia-org-3485	1018	15	;	;	:
en-wikipedia-org-3485	1018	16	Nestler	Nestler	NNP
en-wikipedia-org-3485	1018	17	,	,	,
en-wikipedia-org-3485	1018	18	Eric	Eric	NNP
en-wikipedia-org-3485	1018	19	J.	J.	NNP
en-wikipedia-org-3485	1019	1	(	(	-LRB-
en-wikipedia-org-3485	1019	2	eds	eds	NNP
en-wikipedia-org-3485	1019	3	.	.	.
en-wikipedia-org-3485	1019	4	)	)	-RRB-
en-wikipedia-org-3485	1019	5	.	.	.
en-wikipedia-org-3485	1020	1	Charney	Charney	NNP
en-wikipedia-org-3485	1020	2	&	&	CC
en-wikipedia-org-3485	1020	3	Nestler	Nestler	NNP
en-wikipedia-org-3485	1020	4	's	's	POS
en-wikipedia-org-3485	1020	5	Neurobiology	Neurobiology	NNP
en-wikipedia-org-3485	1020	6	of	of	IN
en-wikipedia-org-3485	1020	7	Mental	Mental	NNP
en-wikipedia-org-3485	1020	8	Illness	Illness	NNP
en-wikipedia-org-3485	1020	9	(	(	-LRB-
en-wikipedia-org-3485	1020	10	5th	5th	JJ
en-wikipedia-org-3485	1020	11	ed	ed	NNP
en-wikipedia-org-3485	1020	12	.	.	.
en-wikipedia-org-3485	1020	13	)	)	-RRB-
en-wikipedia-org-3485	1020	14	.	.	.
en-wikipedia-org-3485	1021	1	New	New	NNP
en-wikipedia-org-3485	1021	2	York	York	NNP
en-wikipedia-org-3485	1021	3	:	:	:
en-wikipedia-org-3485	1021	4	Oxford	Oxford	NNP
en-wikipedia-org-3485	1021	5	University	University	NNP
en-wikipedia-org-3485	1021	6	Press	Press	NNP
en-wikipedia-org-3485	1021	7	.	.	.
en-wikipedia-org-3485	1022	1	ISBN	ISBN	NNP
en-wikipedia-org-3485	1022	2	 	  	_SP
en-wikipedia-org-3485	1022	3	9780190681425	9780190681425	CD
en-wikipedia-org-3485	1022	4	.	.	.
en-wikipedia-org-3485	1023	1	External	external	JJ
en-wikipedia-org-3485	1023	2	links[edit	links[edit	,
en-wikipedia-org-3485	1023	3	]	]	-RRB-
en-wikipedia-org-3485	1023	4	Wikimedia	Wikimedia	NNP
en-wikipedia-org-3485	1023	5	Commons	Commons	NNPS
en-wikipedia-org-3485	1023	6	has	have	VBZ
en-wikipedia-org-3485	1023	7	media	medium	NNS
en-wikipedia-org-3485	1023	8	related	relate	VBN
en-wikipedia-org-3485	1023	9	to	to	IN
en-wikipedia-org-3485	1023	10	Reward	Reward	NNP
en-wikipedia-org-3485	1023	11	system	system	NN
en-wikipedia-org-3485	1023	12	.	.	.
en-wikipedia-org-3485	1024	1	Brain	Brain	NNP
en-wikipedia-org-3485	1024	2	Reward	Reward	NNP
en-wikipedia-org-3485	1024	3	Pathways	Pathways	NNPS
en-wikipedia-org-3485	1024	4	–	–	:
en-wikipedia-org-3485	1024	5	a	a	DT
en-wikipedia-org-3485	1024	6	description	description	NN
en-wikipedia-org-3485	1024	7	of	of	IN
en-wikipedia-org-3485	1024	8	the	the	DT
en-wikipedia-org-3485	1024	9	reward	reward	NN
en-wikipedia-org-3485	1024	10	system	system	NN
en-wikipedia-org-3485	1024	11	published	publish	VBN
en-wikipedia-org-3485	1024	12	by	by	IN
en-wikipedia-org-3485	1024	13	Nestler	Nestler	NNP
en-wikipedia-org-3485	1024	14	Laboratory	Laboratory	NNP
en-wikipedia-org-3485	1024	15	,	,	,
en-wikipedia-org-3485	1024	16	Department	Department	NNP
en-wikipedia-org-3485	1024	17	of	of	IN
en-wikipedia-org-3485	1024	18	Neuroscience	Neuroscience	NNP
en-wikipedia-org-3485	1024	19	,	,	,
en-wikipedia-org-3485	1024	20	Icahn	Icahn	NNP
en-wikipedia-org-3485	1024	21	School	School	NNP
en-wikipedia-org-3485	1024	22	of	of	IN
en-wikipedia-org-3485	1024	23	Medicine	Medicine	NNP
en-wikipedia-org-3485	1024	24	Scholarpedia	Scholarpedia	NNP
en-wikipedia-org-3485	1024	25	Reward	Reward	NNP
en-wikipedia-org-3485	1024	26	Scholarpedia	Scholarpedia	NNP
en-wikipedia-org-3485	1024	27	Reward	Reward	NNP
en-wikipedia-org-3485	1024	28	signals	signal	VBZ
en-wikipedia-org-3485	1024	29	v	v	IN
en-wikipedia-org-3485	1024	30	t	t	NN
en-wikipedia-org-3485	1024	31	e	e	NNP
en-wikipedia-org-3485	1024	32	Reinforcement	reinforcement	NN
en-wikipedia-org-3485	1024	33	disorders	disorder	NNS
en-wikipedia-org-3485	1024	34	:	:	:
en-wikipedia-org-3485	1024	35	Addiction	addiction	NN
en-wikipedia-org-3485	1024	36	and	and	CC
en-wikipedia-org-3485	1024	37	Dependence	Dependence	NNP
en-wikipedia-org-3485	1024	38	Addiction	Addiction	NNP
en-wikipedia-org-3485	1024	39	Drug	Drug	NNP
en-wikipedia-org-3485	1024	40	Alcohol	Alcohol	NNP
en-wikipedia-org-3485	1024	41	Amphetamine	Amphetamine	NNP
en-wikipedia-org-3485	1024	42	Cocaine	Cocaine	NNP
en-wikipedia-org-3485	1024	43	Methamphetamine	Methamphetamine	NNP
en-wikipedia-org-3485	1024	44	Methylphenidate	Methylphenidate	NNP
en-wikipedia-org-3485	1024	45	Nicotine	Nicotine	NNP
en-wikipedia-org-3485	1024	46	Opioid	Opioid	NNP
en-wikipedia-org-3485	1024	47	Behavioral	Behavioral	NNP
en-wikipedia-org-3485	1024	48	Financial	Financial	NNP
en-wikipedia-org-3485	1024	49	Gambling	Gambling	NNP
en-wikipedia-org-3485	1024	50	Shopping	Shopping	NNP
en-wikipedia-org-3485	1024	51	Palatable	palatable	JJ
en-wikipedia-org-3485	1024	52	food	food	NN
en-wikipedia-org-3485	1024	53	Sex	sex	NN
en-wikipedia-org-3485	1024	54	-	-	HYPH
en-wikipedia-org-3485	1024	55	related	relate	VBN
en-wikipedia-org-3485	1024	56	Intercourse	Intercourse	NNP
en-wikipedia-org-3485	1024	57	Pornography	Pornography	NNP
en-wikipedia-org-3485	1024	58	Internet	Internet	NNP
en-wikipedia-org-3485	1024	59	-	-	HYPH
en-wikipedia-org-3485	1024	60	related	relate	VBN
en-wikipedia-org-3485	1024	61	Internet	internet	NN
en-wikipedia-org-3485	1024	62	addiction	addiction	NN
en-wikipedia-org-3485	1024	63	disorder	disorder	NN
en-wikipedia-org-3485	1024	64	Internet	internet	NN
en-wikipedia-org-3485	1024	65	sex	sex	NN
en-wikipedia-org-3485	1024	66	addiction	addiction	NN
en-wikipedia-org-3485	1024	67	Video	video	NN
en-wikipedia-org-3485	1024	68	game	game	NN
en-wikipedia-org-3485	1024	69	addiction	addiction	NN
en-wikipedia-org-3485	1024	70	Digital	Digital	NNP
en-wikipedia-org-3485	1024	71	media	medium	NNS
en-wikipedia-org-3485	1024	72	addictions	addiction	NNS
en-wikipedia-org-3485	1024	73	Cellular	cellular	JJ
en-wikipedia-org-3485	1024	74	mechanisms	mechanisms	NNPS
en-wikipedia-org-3485	1024	75	Transcriptional	Transcriptional	NNP
en-wikipedia-org-3485	1024	76	ΔFosB	ΔFosB	NNP
en-wikipedia-org-3485	1024	77	c	c	NNP
en-wikipedia-org-3485	1024	78	-	-	:
en-wikipedia-org-3485	1024	79	Fos	Fos	NNP
en-wikipedia-org-3485	1024	80	Cdk5	Cdk5	NNP
en-wikipedia-org-3485	1024	81	CREB	CREB	NNP
en-wikipedia-org-3485	1024	82	GluR2	GluR2	NNP
en-wikipedia-org-3485	1024	83	NF	NF	NNP
en-wikipedia-org-3485	1024	84	-	-	HYPH
en-wikipedia-org-3485	1024	85	κB	κB	NNP
en-wikipedia-org-3485	1024	86	Epigenetic	Epigenetic	NNP
en-wikipedia-org-3485	1024	87	G9a	G9a	NNP
en-wikipedia-org-3485	1024	88	G9a	G9a	NNP
en-wikipedia-org-3485	1024	89	-	-	HYPH
en-wikipedia-org-3485	1024	90	like	like	JJ
en-wikipedia-org-3485	1024	91	protein	protein	NN
en-wikipedia-org-3485	1024	92	HDAC1	HDAC1	NNP
en-wikipedia-org-3485	1024	93	HDAC2	HDAC2	NNP
en-wikipedia-org-3485	1024	94	HDAC3	HDAC3	NNP
en-wikipedia-org-3485	1024	95	HDAC4	HDAC4	NNP
en-wikipedia-org-3485	1024	96	HDAC5	HDAC5	NNP
en-wikipedia-org-3485	1024	97	HDAC9	HDAC9	NNP
en-wikipedia-org-3485	1024	98	HDAC10	HDAC10	-LRB-
en-wikipedia-org-3485	1024	99	SIRT1	SIRT1	NNP
en-wikipedia-org-3485	1024	100	SIRT2	sirt2	UH
en-wikipedia-org-3485	1024	101	...	...	.
en-wikipedia-org-3485	1025	1	Dependence	Dependence	NNP
en-wikipedia-org-3485	1025	2	Concepts	Concepts	NNP
en-wikipedia-org-3485	1025	3	Physical	physical	JJ
en-wikipedia-org-3485	1025	4	dependence	dependence	NN
en-wikipedia-org-3485	1025	5	Psychological	psychological	JJ
en-wikipedia-org-3485	1025	6	dependence	dependence	NN
en-wikipedia-org-3485	1025	7	Withdrawal	Withdrawal	NNP
en-wikipedia-org-3485	1025	8	Disorders	Disorders	NNP
en-wikipedia-org-3485	1025	9	Drugs	Drugs	NNP
en-wikipedia-org-3485	1025	10	Alcoholism	Alcoholism	NNP
en-wikipedia-org-3485	1025	11	Amphetamine	Amphetamine	NNP
en-wikipedia-org-3485	1025	12	Barbiturate	Barbiturate	NNP
en-wikipedia-org-3485	1025	13	Benzodiazepine	Benzodiazepine	NNP
en-wikipedia-org-3485	1025	14	Caffeine	Caffeine	NNP
en-wikipedia-org-3485	1025	15	Cannabis	Cannabis	NNP
en-wikipedia-org-3485	1025	16	Cocaine	Cocaine	NNP
en-wikipedia-org-3485	1025	17	Nicotine	Nicotine	NNP
en-wikipedia-org-3485	1025	18	Opioid	Opioid	NNP
en-wikipedia-org-3485	1025	19	Non	Non	NNP
en-wikipedia-org-3485	1025	20	-	-	JJ
en-wikipedia-org-3485	1025	21	drug	drug	JJ
en-wikipedia-org-3485	1025	22	stimuli	stimulus	NNS
en-wikipedia-org-3485	1025	23	Tanning	tan	VBG
en-wikipedia-org-3485	1025	24	dependence	dependence	NN
en-wikipedia-org-3485	1025	25	Treatment	Treatment	NNP
en-wikipedia-org-3485	1025	26	and	and	CC
en-wikipedia-org-3485	1025	27	management	management	NN
en-wikipedia-org-3485	1025	28	Detoxification	Detoxification	NNP
en-wikipedia-org-3485	1025	29	Alcohol	Alcohol	NNP
en-wikipedia-org-3485	1025	30	detoxification	detoxification	NN
en-wikipedia-org-3485	1025	31	Drug	Drug	NNP
en-wikipedia-org-3485	1025	32	detoxification	detoxification	NN
en-wikipedia-org-3485	1025	33	Behavioral	behavioral	JJ
en-wikipedia-org-3485	1025	34	therapies	therapy	NNS
en-wikipedia-org-3485	1025	35	Cognitive	cognitive	JJ
en-wikipedia-org-3485	1025	36	behavioral	behavioral	JJ
en-wikipedia-org-3485	1025	37	therapy	therapy	NN
en-wikipedia-org-3485	1025	38	Relapse	Relapse	NNP
en-wikipedia-org-3485	1025	39	prevention	prevention	NN
en-wikipedia-org-3485	1025	40	Contingency	Contingency	NNP
en-wikipedia-org-3485	1025	41	management	management	NN
en-wikipedia-org-3485	1025	42	Community	Community	NNP
en-wikipedia-org-3485	1025	43	reinforcement	reinforcement	NN
en-wikipedia-org-3485	1025	44	approach	approach	NN
en-wikipedia-org-3485	1025	45	and	and	CC
en-wikipedia-org-3485	1025	46	family	family	NN
en-wikipedia-org-3485	1025	47	training	train	VBG
en-wikipedia-org-3485	1025	48	Motivational	motivational	JJ
en-wikipedia-org-3485	1025	49	enhancement	enhancement	NN
en-wikipedia-org-3485	1025	50	therapy	therapy	NN
en-wikipedia-org-3485	1025	51	Motivational	Motivational	NNP
en-wikipedia-org-3485	1025	52	interviewing	interview	VBG
en-wikipedia-org-3485	1025	53	Motivational	Motivational	NNP
en-wikipedia-org-3485	1025	54	therapy	therapy	NN
en-wikipedia-org-3485	1025	55	Physical	physical	JJ
en-wikipedia-org-3485	1025	56	exercise	exercise	NN
en-wikipedia-org-3485	1025	57	Treatment	Treatment	NNP
en-wikipedia-org-3485	1025	58	programs	program	NNS
en-wikipedia-org-3485	1025	59	Drug	Drug	NNP
en-wikipedia-org-3485	1025	60	rehab	rehab	JJ
en-wikipedia-org-3485	1025	61	Residential	residential	JJ
en-wikipedia-org-3485	1025	62	treatment	treatment	NN
en-wikipedia-org-3485	1025	63	center	center	NN
en-wikipedia-org-3485	1025	64	Heroin	Heroin	NNP
en-wikipedia-org-3485	1025	65	-	-	HYPH
en-wikipedia-org-3485	1025	66	assisted	assist	VBN
en-wikipedia-org-3485	1025	67	treatment	treatment	NN
en-wikipedia-org-3485	1025	68	Intensive	intensive	JJ
en-wikipedia-org-3485	1025	69	outpatient	outpatient	NN
en-wikipedia-org-3485	1025	70	program	program	NN
en-wikipedia-org-3485	1025	71	Methadone	Methadone	NNP
en-wikipedia-org-3485	1025	72	maintenance	maintenance	NN
en-wikipedia-org-3485	1025	73	Smoking	Smoking	NNP
en-wikipedia-org-3485	1025	74	cessation	cessation	NN
en-wikipedia-org-3485	1025	75	Nicotine	Nicotine	NNP
en-wikipedia-org-3485	1025	76	replacement	replacement	NN
en-wikipedia-org-3485	1025	77	therapy	therapy	NN
en-wikipedia-org-3485	1025	78	Tobacco	Tobacco	NNP
en-wikipedia-org-3485	1025	79	cessation	cessation	NN
en-wikipedia-org-3485	1025	80	clinics	clinic	NNS
en-wikipedia-org-3485	1025	81	in	in	IN
en-wikipedia-org-3485	1025	82	India	India	NNP
en-wikipedia-org-3485	1025	83	Twelve	Twelve	NNP
en-wikipedia-org-3485	1025	84	-	-	HYPH
en-wikipedia-org-3485	1025	85	step	step	NN
en-wikipedia-org-3485	1025	86	program	program	NN
en-wikipedia-org-3485	1025	87	Support	support	NN
en-wikipedia-org-3485	1025	88	groups	group	NNS
en-wikipedia-org-3485	1025	89	Addiction	addiction	NN
en-wikipedia-org-3485	1025	90	recovery	recovery	NN
en-wikipedia-org-3485	1025	91	groups	group	NNS
en-wikipedia-org-3485	1025	92	List	list	NN
en-wikipedia-org-3485	1025	93	of	of	IN
en-wikipedia-org-3485	1025	94	twelve	twelve	CD
en-wikipedia-org-3485	1025	95	-	-	HYPH
en-wikipedia-org-3485	1025	96	step	step	NN
en-wikipedia-org-3485	1025	97	groups	group	NNS
en-wikipedia-org-3485	1025	98	Harm	harm	NN
en-wikipedia-org-3485	1025	99	reduction	reduction	NN
en-wikipedia-org-3485	1025	100	Category	category	NN
en-wikipedia-org-3485	1025	101	:	:	:
en-wikipedia-org-3485	1025	102	Harm	harm	NN
en-wikipedia-org-3485	1025	103	reduction	reduction	NN
en-wikipedia-org-3485	1025	104	Drug	drug	NN
en-wikipedia-org-3485	1025	105	checking	check	VBG
en-wikipedia-org-3485	1025	106	Reagent	Reagent	NNP
en-wikipedia-org-3485	1025	107	testing	test	VBG
en-wikipedia-org-3485	1025	108	Low	low	JJ
en-wikipedia-org-3485	1025	109	-	-	HYPH
en-wikipedia-org-3485	1025	110	threshold	threshold	NN
en-wikipedia-org-3485	1025	111	treatment	treatment	NN
en-wikipedia-org-3485	1025	112	programs	program	NNS
en-wikipedia-org-3485	1025	113	Managed	manage	VBN
en-wikipedia-org-3485	1025	114	alcohol	alcohol	NN
en-wikipedia-org-3485	1025	115	program	program	NN
en-wikipedia-org-3485	1025	116	Moderation	Moderation	NNP
en-wikipedia-org-3485	1025	117	Management	Management	NNP
en-wikipedia-org-3485	1025	118	Needle	Needle	NNP
en-wikipedia-org-3485	1025	119	exchange	exchange	NN
en-wikipedia-org-3485	1025	120	program	program	NN
en-wikipedia-org-3485	1025	121	Responsible	responsible	JJ
en-wikipedia-org-3485	1025	122	drug	drug	NN
en-wikipedia-org-3485	1025	123	use	use	NN
en-wikipedia-org-3485	1025	124	Stimulant	stimulant	JJ
en-wikipedia-org-3485	1025	125	maintenance	maintenance	NN
en-wikipedia-org-3485	1025	126	Supervised	supervise	VBN
en-wikipedia-org-3485	1025	127	injection	injection	NN
en-wikipedia-org-3485	1025	128	site	site	NN
en-wikipedia-org-3485	1025	129	Tobacco	tobacco	NN
en-wikipedia-org-3485	1025	130	harm	harm	NN
en-wikipedia-org-3485	1025	131	reduction	reduction	NN
en-wikipedia-org-3485	1025	132	See	see	VB
en-wikipedia-org-3485	1025	133	also	also	RB
en-wikipedia-org-3485	1025	134	Addiction	addiction	NN
en-wikipedia-org-3485	1025	135	medicine	medicine	NN
en-wikipedia-org-3485	1025	136	Allen	Allen	NNP
en-wikipedia-org-3485	1025	137	Carr	Carr	NNP
en-wikipedia-org-3485	1025	138	Category	Category	NNP
en-wikipedia-org-3485	1025	139	:	:	:
en-wikipedia-org-3485	1025	140	Addiction	addiction	NN
en-wikipedia-org-3485	1025	141	Discrimination	discrimination	NN
en-wikipedia-org-3485	1025	142	against	against	IN
en-wikipedia-org-3485	1025	143	drug	drug	NN
en-wikipedia-org-3485	1025	144	addicts	addict	NNS
en-wikipedia-org-3485	1025	145	Dopamine	Dopamine	NNP
en-wikipedia-org-3485	1025	146	dysregulation	dysregulation	NN
en-wikipedia-org-3485	1025	147	syndrome	syndrome	NN
en-wikipedia-org-3485	1025	148	Cognitive	Cognitive	NNP
en-wikipedia-org-3485	1025	149	control	control	NN
en-wikipedia-org-3485	1025	150	Inhibitory	Inhibitory	NNP
en-wikipedia-org-3485	1025	151	control	control	VB
en-wikipedia-org-3485	1025	152	Motivational	motivational	JJ
en-wikipedia-org-3485	1025	153	salience	salience	NN
en-wikipedia-org-3485	1025	154	Incentive	Incentive	NNP
en-wikipedia-org-3485	1025	155	salience	salience	NN
en-wikipedia-org-3485	1025	156	Sober	Sober	NNP
en-wikipedia-org-3485	1025	157	companion	companion	NN
en-wikipedia-org-3485	1025	158	Category	Category	NNP
en-wikipedia-org-3485	1025	159	Psychology	Psychology	NNP
en-wikipedia-org-3485	1025	160	portal	portal	JJ
en-wikipedia-org-3485	1025	161	Biology	Biology	NNP
en-wikipedia-org-3485	1025	162	portal	portal	NN
en-wikipedia-org-3485	1025	163	Retrieved	retrieve	VBN
en-wikipedia-org-3485	1025	164	from	from	IN
en-wikipedia-org-3485	1025	165	"	"	``
en-wikipedia-org-3485	1025	166	https://en.wikipedia.org/w/index.php?title=Reward_system&oldid=991811794#Pleasure_centers	https://en.wikipedia.org/w/index.php?title=reward_system&oldid=991811794#pleasure_center	NNS
en-wikipedia-org-3485	1025	167	"	"	''
en-wikipedia-org-3485	1025	168	Categories	category	NNS
en-wikipedia-org-3485	1025	169	:	:	:
en-wikipedia-org-3485	1025	170	Cognitive	cognitive	VB
en-wikipedia-org-3485	1025	171	neuroscience	neuroscience	VB
en-wikipedia-org-3485	1025	172	Behavioral	behavioral	JJ
en-wikipedia-org-3485	1025	173	neuroscience	neuroscience	NN
en-wikipedia-org-3485	1025	174	Behaviorism	Behaviorism	NNP
en-wikipedia-org-3485	1025	175	Behavior	Behavior	NNP
en-wikipedia-org-3485	1025	176	modification	modification	NN
en-wikipedia-org-3485	1025	177	Addiction	Addiction	NNP
en-wikipedia-org-3485	1025	178	Neuroanatomy	Neuroanatomy	NNP
en-wikipedia-org-3485	1025	179	Neuropsychology	Neuropsychology	NNP
en-wikipedia-org-3485	1025	180	Dopamine	Dopamine	NNP
en-wikipedia-org-3485	1025	181	Psychological	psychological	JJ
en-wikipedia-org-3485	1025	182	manipulation	manipulation	NN
en-wikipedia-org-3485	1025	183	Hidden	hide	VBN
en-wikipedia-org-3485	1025	184	categories	category	NNS
en-wikipedia-org-3485	1025	185	:	:	:
en-wikipedia-org-3485	1025	186	CS1	cs1	NN
en-wikipedia-org-3485	1025	187	:	:	:
en-wikipedia-org-3485	1025	188	long	long	JJ
en-wikipedia-org-3485	1025	189	volume	volume	NN
en-wikipedia-org-3485	1025	190	value	value	NN
en-wikipedia-org-3485	1025	191	Harv	Harv	NNP
en-wikipedia-org-3485	1025	192	and	and	CC
en-wikipedia-org-3485	1025	193	Sfn	Sfn	NNP
en-wikipedia-org-3485	1025	194	no	no	DT
en-wikipedia-org-3485	1025	195	-	-	HYPH
en-wikipedia-org-3485	1025	196	target	target	NN
en-wikipedia-org-3485	1025	197	errors	error	NNS
en-wikipedia-org-3485	1025	198	Articles	article	NNS
en-wikipedia-org-3485	1025	199	with	with	IN
en-wikipedia-org-3485	1025	200	short	short	JJ
en-wikipedia-org-3485	1025	201	description	description	NN
en-wikipedia-org-3485	1025	202	Short	short	JJ
en-wikipedia-org-3485	1025	203	description	description	NN
en-wikipedia-org-3485	1025	204	is	be	VBZ
en-wikipedia-org-3485	1025	205	different	different	JJ
en-wikipedia-org-3485	1025	206	from	from	IN
en-wikipedia-org-3485	1025	207	Wikidata	Wikidata	NNP
en-wikipedia-org-3485	1025	208	Use	Use	NNP
en-wikipedia-org-3485	1025	209	dmy	dmy	NN
en-wikipedia-org-3485	1025	210	dates	date	NNS
en-wikipedia-org-3485	1025	211	from	from	IN
en-wikipedia-org-3485	1025	212	June	June	NNP
en-wikipedia-org-3485	1025	213	2018	2018	CD
en-wikipedia-org-3485	1025	214	Pages	Pages	NNPS
en-wikipedia-org-3485	1025	215	using	use	VBG
en-wikipedia-org-3485	1025	216	multiple	multiple	JJ
en-wikipedia-org-3485	1025	217	image	image	NN
en-wikipedia-org-3485	1025	218	with	with	IN
en-wikipedia-org-3485	1025	219	auto	auto	NN
en-wikipedia-org-3485	1025	220	scaled	scale	VBN
en-wikipedia-org-3485	1025	221	images	image	NNS
en-wikipedia-org-3485	1025	222	Articles	Articles	NNPS
en-wikipedia-org-3485	1025	223	containing	contain	VBG
en-wikipedia-org-3485	1025	224	potentially	potentially	RB
en-wikipedia-org-3485	1025	225	dated	date	VBN
en-wikipedia-org-3485	1025	226	statements	statement	NNS
en-wikipedia-org-3485	1025	227	from	from	IN
en-wikipedia-org-3485	1025	228	October	October	NNP
en-wikipedia-org-3485	1025	229	2017	2017	CD
en-wikipedia-org-3485	1025	230	All	all	DT
en-wikipedia-org-3485	1025	231	articles	article	NNS
en-wikipedia-org-3485	1025	232	containing	contain	VBG
en-wikipedia-org-3485	1025	233	potentially	potentially	RB
en-wikipedia-org-3485	1025	234	dated	date	VBN
en-wikipedia-org-3485	1025	235	statements	statement	NNS
en-wikipedia-org-3485	1025	236	Commons	Commons	NNPS
en-wikipedia-org-3485	1025	237	category	category	NN
en-wikipedia-org-3485	1025	238	link	link	NN
en-wikipedia-org-3485	1025	239	is	be	VBZ
en-wikipedia-org-3485	1025	240	on	on	IN
en-wikipedia-org-3485	1025	241	Wikidata	Wikidata	NNP
en-wikipedia-org-3485	1025	242	Navigation	Navigation	NNP
en-wikipedia-org-3485	1025	243	menu	menu	NN
en-wikipedia-org-3485	1025	244	Personal	personal	JJ
en-wikipedia-org-3485	1025	245	tools	tool	NNS
en-wikipedia-org-3485	1025	246	Not	not	RB
en-wikipedia-org-3485	1025	247	logged	log	VBN
en-wikipedia-org-3485	1025	248	in	in	IN
en-wikipedia-org-3485	1025	249	Talk	Talk	NNP
en-wikipedia-org-3485	1025	250	Contributions	Contributions	NNP
en-wikipedia-org-3485	1025	251	Create	Create	NNP
en-wikipedia-org-3485	1025	252	account	account	NN
en-wikipedia-org-3485	1025	253	Log	Log	NNP
en-wikipedia-org-3485	1025	254	in	in	IN
en-wikipedia-org-3485	1025	255	Namespaces	Namespaces	NNP
en-wikipedia-org-3485	1025	256	Article	Article	NNP
en-wikipedia-org-3485	1025	257	Talk	talk	NN
en-wikipedia-org-3485	1025	258	Variants	variant	VBZ
en-wikipedia-org-3485	1025	259	Views	view	NNS
en-wikipedia-org-3485	1025	260	Read	read	VBP
en-wikipedia-org-3485	1025	261	Edit	edit	NN
en-wikipedia-org-3485	1025	262	View	View	NNP
en-wikipedia-org-3485	1025	263	history	history	NN
en-wikipedia-org-3485	1025	264	More	More	JJR
en-wikipedia-org-3485	1025	265	Search	Search	NNP
en-wikipedia-org-3485	1025	266	Navigation	Navigation	NNP
en-wikipedia-org-3485	1025	267	Main	Main	NNP
en-wikipedia-org-3485	1025	268	page	page	NN
en-wikipedia-org-3485	1025	269	Contents	content	VBZ
en-wikipedia-org-3485	1025	270	Current	current	JJ
en-wikipedia-org-3485	1025	271	events	event	NNS
en-wikipedia-org-3485	1025	272	Random	random	JJ
en-wikipedia-org-3485	1025	273	article	article	NN
en-wikipedia-org-3485	1025	274	About	about	IN
en-wikipedia-org-3485	1025	275	Wikipedia	Wikipedia	NNP
en-wikipedia-org-3485	1025	276	Contact	Contact	NNP
en-wikipedia-org-3485	1025	277	us	-PRON-	PRP
en-wikipedia-org-3485	1025	278	Donate	Donate	NNP
en-wikipedia-org-3485	1025	279	Contribute	contribute	NN
en-wikipedia-org-3485	1025	280	Help	help	NN
en-wikipedia-org-3485	1025	281	Learn	learn	VB
en-wikipedia-org-3485	1025	282	to	to	TO
en-wikipedia-org-3485	1025	283	edit	edit	VB
en-wikipedia-org-3485	1025	284	Community	community	NN
en-wikipedia-org-3485	1025	285	portal	portal	JJ
en-wikipedia-org-3485	1025	286	Recent	recent	JJ
en-wikipedia-org-3485	1025	287	changes	change	NNS
en-wikipedia-org-3485	1025	288	Upload	upload	JJ
en-wikipedia-org-3485	1025	289	file	file	NN
en-wikipedia-org-3485	1025	290	Tools	tool	NNS
en-wikipedia-org-3485	1025	291	What	what	WP
en-wikipedia-org-3485	1025	292	links	link	NNS
en-wikipedia-org-3485	1025	293	here	here	RB
en-wikipedia-org-3485	1025	294	Related	relate	VBN
en-wikipedia-org-3485	1025	295	changes	change	VBZ
en-wikipedia-org-3485	1025	296	Upload	upload	JJ
en-wikipedia-org-3485	1025	297	file	file	VBP
en-wikipedia-org-3485	1025	298	Special	special	JJ
en-wikipedia-org-3485	1025	299	pages	page	NNS
en-wikipedia-org-3485	1025	300	Permanent	permanent	JJ
en-wikipedia-org-3485	1025	301	link	link	NN
en-wikipedia-org-3485	1025	302	Page	Page	NNP
en-wikipedia-org-3485	1025	303	information	information	NN
en-wikipedia-org-3485	1025	304	Cite	cite	VB
en-wikipedia-org-3485	1025	305	this	this	DT
en-wikipedia-org-3485	1025	306	page	page	NN
en-wikipedia-org-3485	1025	307	Wikidata	wikidata	NN
en-wikipedia-org-3485	1025	308	item	item	NN
en-wikipedia-org-3485	1025	309	Print	print	NN
en-wikipedia-org-3485	1025	310	/	/	SYM
en-wikipedia-org-3485	1025	311	export	export	NN
en-wikipedia-org-3485	1025	312	Download	Download	NNP
en-wikipedia-org-3485	1025	313	as	as	IN
en-wikipedia-org-3485	1025	314	PDF	PDF	NNP
en-wikipedia-org-3485	1025	315	Printable	Printable	NNP
en-wikipedia-org-3485	1025	316	version	version	NN
en-wikipedia-org-3485	1025	317	In	in	IN
en-wikipedia-org-3485	1025	318	other	other	JJ
en-wikipedia-org-3485	1025	319	projects	project	NNS
en-wikipedia-org-3485	1025	320	Wikimedia	Wikimedia	NNP
en-wikipedia-org-3485	1025	321	Commons	Commons	NNPS
en-wikipedia-org-3485	1025	322	Languages	Languages	NNPS
en-wikipedia-org-3485	1025	323	العربية	العربية	NN
en-wikipedia-org-3485	1025	324	فارسی	فارسی	NNP
en-wikipedia-org-3485	1025	325	Français	Français	NNP
en-wikipedia-org-3485	1025	326	한국어	한국어	NN
en-wikipedia-org-3485	1025	327	हिन्दी	हिन्दी	VBD
en-wikipedia-org-3485	1025	328	Italiano	Italiano	NNP
en-wikipedia-org-3485	1025	329	עברית	עברית	NN
en-wikipedia-org-3485	1025	330	Nederlands	Nederlands	NNP
en-wikipedia-org-3485	1025	331	日本語	日本語	NNP
en-wikipedia-org-3485	1025	332	Polski	Polski	NNP
en-wikipedia-org-3485	1025	333	Русский	Русский	NNP
en-wikipedia-org-3485	1025	334	Svenska	Svenska	NNP
en-wikipedia-org-3485	1025	335	ไทย	ไทย	NN
en-wikipedia-org-3485	1025	336	Українська	Українська	NNP
en-wikipedia-org-3485	1025	337	Tiếng	Tiếng	NNP
en-wikipedia-org-3485	1025	338	Việt	Việt	NNP
en-wikipedia-org-3485	1025	339	中文	中文	NNP
en-wikipedia-org-3485	1025	340	Edit	Edit	NNP
en-wikipedia-org-3485	1025	341	links	link	NNS
en-wikipedia-org-3485	1025	342	This	this	DT
en-wikipedia-org-3485	1025	343	page	page	NN
en-wikipedia-org-3485	1025	344	was	be	VBD
en-wikipedia-org-3485	1025	345	last	last	RB
en-wikipedia-org-3485	1025	346	edited	edit	VBN
en-wikipedia-org-3485	1025	347	on	on	IN
en-wikipedia-org-3485	1025	348	1	1	CD
en-wikipedia-org-3485	1025	349	December	December	NNP
en-wikipedia-org-3485	1025	350	2020	2020	CD
en-wikipedia-org-3485	1025	351	,	,	,
en-wikipedia-org-3485	1025	352	at	at	IN
en-wikipedia-org-3485	1025	353	23:10	23:10	CD
en-wikipedia-org-3485	1025	354	 	  	_SP
en-wikipedia-org-3485	1025	355	(	(	-LRB-
en-wikipedia-org-3485	1025	356	UTC	UTC	NNP
en-wikipedia-org-3485	1025	357	)	)	-RRB-
en-wikipedia-org-3485	1025	358	.	.	.
en-wikipedia-org-3485	1026	1	Text	text	NN
en-wikipedia-org-3485	1026	2	is	be	VBZ
en-wikipedia-org-3485	1026	3	available	available	JJ
en-wikipedia-org-3485	1026	4	under	under	IN
en-wikipedia-org-3485	1026	5	the	the	DT
en-wikipedia-org-3485	1026	6	Creative	Creative	NNP
en-wikipedia-org-3485	1026	7	Commons	Commons	NNP
en-wikipedia-org-3485	1026	8	Attribution	Attribution	NNP
en-wikipedia-org-3485	1026	9	-	-	HYPH
en-wikipedia-org-3485	1026	10	ShareAlike	ShareAlike	NNP
en-wikipedia-org-3485	1026	11	License	License	NNP
en-wikipedia-org-3485	1026	12	;	;	,
en-wikipedia-org-3485	1026	13	additional	additional	JJ
en-wikipedia-org-3485	1026	14	terms	term	NNS
en-wikipedia-org-3485	1026	15	may	may	MD
en-wikipedia-org-3485	1026	16	apply	apply	VB
en-wikipedia-org-3485	1026	17	.	.	.
en-wikipedia-org-3485	1027	1	By	by	IN
en-wikipedia-org-3485	1027	2	using	use	VBG
en-wikipedia-org-3485	1027	3	this	this	DT
en-wikipedia-org-3485	1027	4	site	site	NN
en-wikipedia-org-3485	1027	5	,	,	,
en-wikipedia-org-3485	1027	6	you	-PRON-	PRP
en-wikipedia-org-3485	1027	7	agree	agree	VBP
en-wikipedia-org-3485	1027	8	to	to	IN
en-wikipedia-org-3485	1027	9	the	the	DT
en-wikipedia-org-3485	1027	10	Terms	term	NNS
en-wikipedia-org-3485	1027	11	of	of	IN
en-wikipedia-org-3485	1027	12	Use	Use	NNP
en-wikipedia-org-3485	1027	13	and	and	CC
en-wikipedia-org-3485	1027	14	Privacy	Privacy	NNP
en-wikipedia-org-3485	1027	15	Policy	Policy	NNP
en-wikipedia-org-3485	1027	16	.	.	.
en-wikipedia-org-3485	1028	1	Wikipedia	Wikipedia	NNP
en-wikipedia-org-3485	1028	2	®	®	NNPS
en-wikipedia-org-3485	1028	3	is	be	VBZ
en-wikipedia-org-3485	1028	4	a	a	DT
en-wikipedia-org-3485	1028	5	registered	registered	JJ
en-wikipedia-org-3485	1028	6	trademark	trademark	NN
en-wikipedia-org-3485	1028	7	of	of	IN
en-wikipedia-org-3485	1028	8	the	the	DT
en-wikipedia-org-3485	1028	9	Wikimedia	Wikimedia	NNP
en-wikipedia-org-3485	1028	10	Foundation	Foundation	NNP
en-wikipedia-org-3485	1028	11	,	,	,
en-wikipedia-org-3485	1028	12	Inc.	Inc.	NNP
en-wikipedia-org-3485	1028	13	,	,	,
en-wikipedia-org-3485	1028	14	a	a	DT
en-wikipedia-org-3485	1028	15	non	non	JJ
en-wikipedia-org-3485	1028	16	-	-	JJ
en-wikipedia-org-3485	1028	17	profit	profit	JJ
en-wikipedia-org-3485	1028	18	organization	organization	NN
en-wikipedia-org-3485	1028	19	.	.	.
en-wikipedia-org-3485	1029	1	Privacy	privacy	NN
en-wikipedia-org-3485	1029	2	policy	policy	NN
en-wikipedia-org-3485	1029	3	About	about	IN
en-wikipedia-org-3485	1029	4	Wikipedia	Wikipedia	NNP
en-wikipedia-org-3485	1029	5	Disclaimers	Disclaimers	NNPS
en-wikipedia-org-3485	1029	6	Contact	Contact	NNP
en-wikipedia-org-3485	1029	7	Wikipedia	Wikipedia	NNP
en-wikipedia-org-3485	1029	8	Mobile	Mobile	NNP
en-wikipedia-org-3485	1029	9	view	view	NN
en-wikipedia-org-3485	1029	10	Developers	Developers	NNP
en-wikipedia-org-3485	1029	11	Statistics	Statistics	NNP
en-wikipedia-org-3485	1029	12	Cookie	Cookie	NNP
en-wikipedia-org-3485	1029	13	statement	statement	NN