id	sid	tid	token	lemma	pos
en-wikipedia-org-4107	1	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1	2	-	-	HYPH
en-wikipedia-org-4107	1	3	Wikipedia	Wikipedia	NNP
en-wikipedia-org-4107	1	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1	5	From	from	IN
en-wikipedia-org-4107	1	6	Wikipedia	Wikipedia	NNP
en-wikipedia-org-4107	1	7	,	,	,
en-wikipedia-org-4107	1	8	the	the	DT
en-wikipedia-org-4107	1	9	free	free	JJ
en-wikipedia-org-4107	1	10	encyclopedia	encyclopedia	NN
en-wikipedia-org-4107	1	11	Jump	Jump	NNP
en-wikipedia-org-4107	1	12	to	to	IN
en-wikipedia-org-4107	1	13	navigation	navigation	NN
en-wikipedia-org-4107	1	14	Jump	Jump	NNP
en-wikipedia-org-4107	1	15	to	to	TO
en-wikipedia-org-4107	1	16	search	search	VB
en-wikipedia-org-4107	1	17	central	central	JJ
en-wikipedia-org-4107	1	18	nervous	nervous	JJ
en-wikipedia-org-4107	1	19	system	system	NN
en-wikipedia-org-4107	1	20	stimulant	stimulant	NN
en-wikipedia-org-4107	1	21	This	this	DT
en-wikipedia-org-4107	1	22	article	article	NN
en-wikipedia-org-4107	1	23	is	be	VBZ
en-wikipedia-org-4107	1	24	about	about	IN
en-wikipedia-org-4107	1	25	the	the	DT
en-wikipedia-org-4107	1	26	stimulant	stimulant	JJ
en-wikipedia-org-4107	1	27	drug	drug	NN
en-wikipedia-org-4107	1	28	's	's	POS
en-wikipedia-org-4107	1	29	racemate	racemate	NN
en-wikipedia-org-4107	1	30	and	and	CC
en-wikipedia-org-4107	1	31	other	other	JJ
en-wikipedia-org-4107	1	32	mixtures	mixture	NNS
en-wikipedia-org-4107	1	33	.	.	.
en-wikipedia-org-4107	2	1	For	for	IN
en-wikipedia-org-4107	2	2	other	other	JJ
en-wikipedia-org-4107	2	3	uses	use	NNS
en-wikipedia-org-4107	2	4	,	,	,
en-wikipedia-org-4107	2	5	see	see	VB
en-wikipedia-org-4107	2	6	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2	7	(	(	-LRB-
en-wikipedia-org-4107	2	8	disambiguation	disambiguation	NNP
en-wikipedia-org-4107	2	9	)	)	-RRB-
en-wikipedia-org-4107	2	10	.	.	.
en-wikipedia-org-4107	3	1	"	"	``
en-wikipedia-org-4107	3	2	Benzedrine	Benzedrine	NNP
en-wikipedia-org-4107	3	3	"	"	''
en-wikipedia-org-4107	3	4	redirects	redirect	VBZ
en-wikipedia-org-4107	3	5	here	here	RB
en-wikipedia-org-4107	3	6	.	.	.
en-wikipedia-org-4107	4	1	For	for	IN
en-wikipedia-org-4107	4	2	information	information	NN
en-wikipedia-org-4107	4	3	about	about	IN
en-wikipedia-org-4107	4	4	the	the	DT
en-wikipedia-org-4107	4	5	brand	brand	NN
en-wikipedia-org-4107	4	6	's	's	POS
en-wikipedia-org-4107	4	7	socio	socio	JJ
en-wikipedia-org-4107	4	8	-	-	HYPH
en-wikipedia-org-4107	4	9	cultural	cultural	JJ
en-wikipedia-org-4107	4	10	impact	impact	NN
en-wikipedia-org-4107	4	11	,	,	,
en-wikipedia-org-4107	4	12	see	see	VB
en-wikipedia-org-4107	4	13	History	history	NN
en-wikipedia-org-4107	4	14	of	of	IN
en-wikipedia-org-4107	4	15	Benzedrine	Benzedrine	NNP
en-wikipedia-org-4107	4	16	.	.	.
en-wikipedia-org-4107	5	1	"	"	``
en-wikipedia-org-4107	5	2	thyramine	thyramine	NN
en-wikipedia-org-4107	5	3	"	"	''
en-wikipedia-org-4107	5	4	redirects	redirect	VBZ
en-wikipedia-org-4107	5	5	here	here	RB
en-wikipedia-org-4107	5	6	.	.	.
en-wikipedia-org-4107	6	1	It	-PRON-	PRP
en-wikipedia-org-4107	6	2	is	be	VBZ
en-wikipedia-org-4107	6	3	not	not	RB
en-wikipedia-org-4107	6	4	to	to	TO
en-wikipedia-org-4107	6	5	be	be	VB
en-wikipedia-org-4107	6	6	confused	confuse	VBN
en-wikipedia-org-4107	6	7	with	with	IN
en-wikipedia-org-4107	6	8	tyramine	tyramine	NN
en-wikipedia-org-4107	6	9	.	.	.
en-wikipedia-org-4107	7	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	7	2	INN	INN	NNP
en-wikipedia-org-4107	7	3	:	:	:
en-wikipedia-org-4107	7	4	Amfetamine	Amfetamine	NNP
en-wikipedia-org-4107	7	5	Clinical	Clinical	NNP
en-wikipedia-org-4107	7	6	data	datum	NNS
en-wikipedia-org-4107	7	7	Pronunciation	Pronunciation	NNP
en-wikipedia-org-4107	7	8	/æmˈfɛtəmiːn/	/æmˈfɛtəmiːn/	.
en-wikipedia-org-4107	7	9	(	(	-LRB-
en-wikipedia-org-4107	7	10	listen	listen	VB
en-wikipedia-org-4107	7	11	)	)	-RRB-
en-wikipedia-org-4107	7	12	Trade	Trade	NNP
en-wikipedia-org-4107	7	13	names	name	NNS
en-wikipedia-org-4107	7	14	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	7	15	,	,	,
en-wikipedia-org-4107	7	16	Adderall[note	Adderall[note	``
en-wikipedia-org-4107	7	17	1	1	CD
en-wikipedia-org-4107	7	18	]	]	-RRB-
en-wikipedia-org-4107	7	19	,	,	,
en-wikipedia-org-4107	7	20	others	other	NNS
en-wikipedia-org-4107	7	21	Other	other	JJ
en-wikipedia-org-4107	7	22	names	name	NNS
en-wikipedia-org-4107	7	23	α	α	CD
en-wikipedia-org-4107	7	24	-	-	HYPH
en-wikipedia-org-4107	7	25	methylphenethylamine	methylphenethylamine	NN
en-wikipedia-org-4107	7	26	AHFS	ahfs	NN
en-wikipedia-org-4107	7	27	/	/	SYM
en-wikipedia-org-4107	7	28	Drugs.com	Drugs.com	NNP
en-wikipedia-org-4107	7	29	Monograph	Monograph	NNP
en-wikipedia-org-4107	7	30	MedlinePlus	MedlinePlus	NNP
en-wikipedia-org-4107	7	31	a616004	a616004	NNP
en-wikipedia-org-4107	7	32	License	License	NNP
en-wikipedia-org-4107	7	33	data	datum	NNS
en-wikipedia-org-4107	7	34	US	US	NNP
en-wikipedia-org-4107	7	35	 	  	_SP
en-wikipedia-org-4107	7	36	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	7	37	:	:	:
en-wikipedia-org-4107	7	38	 	  	_SP
en-wikipedia-org-4107	7	39	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	7	40	Pregnancy	Pregnancy	NNP
en-wikipedia-org-4107	7	41	category	category	NN
en-wikipedia-org-4107	7	42	US	US	NNP
en-wikipedia-org-4107	7	43	:	:	:
en-wikipedia-org-4107	7	44	C	C	NNP
en-wikipedia-org-4107	7	45	(	(	-LRB-
en-wikipedia-org-4107	7	46	Risk	Risk	NNP
en-wikipedia-org-4107	7	47	not	not	RB
en-wikipedia-org-4107	7	48	ruled	rule	VBD
en-wikipedia-org-4107	7	49	out)[1	out)[1	''
en-wikipedia-org-4107	7	50	]	]	-RRB-
en-wikipedia-org-4107	7	51	Dependence	Dependence	NNP
en-wikipedia-org-4107	7	52	liability	liability	NN
en-wikipedia-org-4107	7	53	Moderate[2	moderate[2	NN
en-wikipedia-org-4107	7	54	]	]	-RRB-
en-wikipedia-org-4107	7	55	Addiction	addiction	NN
en-wikipedia-org-4107	7	56	liability	liability	NN
en-wikipedia-org-4107	7	57	Moderate	Moderate	NNP
en-wikipedia-org-4107	7	58	Routes	Routes	NNP
en-wikipedia-org-4107	7	59	of	of	IN
en-wikipedia-org-4107	7	60	administration	administration	NN
en-wikipedia-org-4107	7	61	Medical	medical	JJ
en-wikipedia-org-4107	7	62	:	:	:
en-wikipedia-org-4107	7	63	oral	oral	JJ
en-wikipedia-org-4107	7	64	,	,	,
en-wikipedia-org-4107	7	65	intravenous[3	intravenous[3	NNP
en-wikipedia-org-4107	7	66	]	]	-RRB-
en-wikipedia-org-4107	7	67	Recreational	recreational	JJ
en-wikipedia-org-4107	7	68	:	:	:
en-wikipedia-org-4107	7	69	oral	oral	JJ
en-wikipedia-org-4107	7	70	,	,	,
en-wikipedia-org-4107	7	71	insufflation	insufflation	NN
en-wikipedia-org-4107	7	72	,	,	,
en-wikipedia-org-4107	7	73	rectal	rectal	JJ
en-wikipedia-org-4107	7	74	,	,	,
en-wikipedia-org-4107	7	75	intravenous	intravenous	JJ
en-wikipedia-org-4107	7	76	,	,	,
en-wikipedia-org-4107	7	77	intramuscular	intramuscular	JJ
en-wikipedia-org-4107	7	78	Drug	drug	NN
en-wikipedia-org-4107	7	79	class	class	NN
en-wikipedia-org-4107	7	80	CNS	cns	NN
en-wikipedia-org-4107	7	81	stimulant	stimulant	NN
en-wikipedia-org-4107	7	82	,	,	,
en-wikipedia-org-4107	7	83	anorectic	anorectic	JJ
en-wikipedia-org-4107	7	84	ATC	ATC	NNP
en-wikipedia-org-4107	7	85	code	code	NN
en-wikipedia-org-4107	7	86	N06BA01	n06ba01	NN
en-wikipedia-org-4107	7	87	(	(	-LRB-
en-wikipedia-org-4107	7	88	WHO	who	WP
en-wikipedia-org-4107	7	89	)	)	-RRB-
en-wikipedia-org-4107	7	90	N06BA02	n06ba02	JJ
en-wikipedia-org-4107	7	91	(	(	-LRB-
en-wikipedia-org-4107	7	92	WHO	who	WP
en-wikipedia-org-4107	7	93	)	)	-RRB-
en-wikipedia-org-4107	7	94	N06BA12	N06BA12	NNS
en-wikipedia-org-4107	7	95	(	(	-LRB-
en-wikipedia-org-4107	7	96	WHO	who	WP
en-wikipedia-org-4107	7	97	)	)	-RRB-
en-wikipedia-org-4107	7	98	Legal	legal	JJ
en-wikipedia-org-4107	7	99	status	status	NN
en-wikipedia-org-4107	7	100	Legal	legal	JJ
en-wikipedia-org-4107	7	101	status	status	NN
en-wikipedia-org-4107	7	102	AU	AU	NNP
en-wikipedia-org-4107	7	103	:	:	:
en-wikipedia-org-4107	7	104	S8	S8	NNP
en-wikipedia-org-4107	7	105	(	(	-LRB-
en-wikipedia-org-4107	7	106	Controlled	control	VBN
en-wikipedia-org-4107	7	107	drug	drug	NN
en-wikipedia-org-4107	7	108	)	)	-RRB-
en-wikipedia-org-4107	7	109	BR	BR	NNP
en-wikipedia-org-4107	7	110	:	:	:
en-wikipedia-org-4107	7	111	Class	class	NN
en-wikipedia-org-4107	7	112	A3	a3	NN
en-wikipedia-org-4107	7	113	(	(	-LRB-
en-wikipedia-org-4107	7	114	Psychoactive	psychoactive	JJ
en-wikipedia-org-4107	7	115	drugs	drug	NNS
en-wikipedia-org-4107	7	116	)	)	-RRB-
en-wikipedia-org-4107	7	117	CA	CA	NNP
en-wikipedia-org-4107	7	118	:	:	:
en-wikipedia-org-4107	7	119	Schedule	schedule	NN
en-wikipedia-org-4107	7	120	I	-PRON-	PRP
en-wikipedia-org-4107	7	121	DE	de	NN
en-wikipedia-org-4107	7	122	:	:	:
en-wikipedia-org-4107	7	123	Anlage	anlage	NN
en-wikipedia-org-4107	7	124	III	iii	CD
en-wikipedia-org-4107	7	125	(	(	-LRB-
en-wikipedia-org-4107	7	126	Special	special	JJ
en-wikipedia-org-4107	7	127	prescription	prescription	NN
en-wikipedia-org-4107	7	128	form	form	NN
en-wikipedia-org-4107	7	129	required	require	VBN
en-wikipedia-org-4107	7	130	)	)	-RRB-
en-wikipedia-org-4107	7	131	NZ	NZ	NNP
en-wikipedia-org-4107	7	132	:	:	:
en-wikipedia-org-4107	7	133	Class	Class	NNP
en-wikipedia-org-4107	7	134	B	B	NNP
en-wikipedia-org-4107	7	135	UK	UK	NNP
en-wikipedia-org-4107	7	136	:	:	:
en-wikipedia-org-4107	7	137	Class	class	NN
en-wikipedia-org-4107	7	138	B	b	NN
en-wikipedia-org-4107	7	139	US	US	NNP
en-wikipedia-org-4107	7	140	:	:	:
en-wikipedia-org-4107	7	141	Schedule	schedule	NN
en-wikipedia-org-4107	7	142	II	II	NNP
en-wikipedia-org-4107	7	143	UN	UN	NNP
en-wikipedia-org-4107	7	144	:	:	:
en-wikipedia-org-4107	7	145	Psychotropic	Psychotropic	NNP
en-wikipedia-org-4107	7	146	Schedule	schedule	NN
en-wikipedia-org-4107	7	147	 	  	_SP
en-wikipedia-org-4107	7	148	II	II	NNP
en-wikipedia-org-4107	7	149	Pharmacokinetic	pharmacokinetic	JJ
en-wikipedia-org-4107	7	150	data	datum	NNS
en-wikipedia-org-4107	7	151	Bioavailability	Bioavailability	NNP
en-wikipedia-org-4107	7	152	Oral	Oral	NNP
en-wikipedia-org-4107	7	153	:	:	:
en-wikipedia-org-4107	7	154	75–100%[4	75–100%[4	NN
en-wikipedia-org-4107	7	155	]	]	-RRB-
en-wikipedia-org-4107	7	156	Protein	protein	NN
en-wikipedia-org-4107	7	157	binding	bind	VBG
en-wikipedia-org-4107	7	158	20%[5	20%[5	CD
en-wikipedia-org-4107	7	159	]	]	-RRB-
en-wikipedia-org-4107	7	160	Metabolism	metabolism	NN
en-wikipedia-org-4107	7	161	CYP2D6,[6	CYP2D6,[6	.
en-wikipedia-org-4107	7	162	]	]	-RRB-
en-wikipedia-org-4107	7	163	DBH,[14][15	dbh,[14][15	JJ
en-wikipedia-org-4107	7	164	]	]	-RRB-
en-wikipedia-org-4107	7	165	FMO3[14][16][17	FMO3[14][16][17	NNP
en-wikipedia-org-4107	7	166	]	]	-RRB-
en-wikipedia-org-4107	7	167	Metabolites	metabolite	NNS
en-wikipedia-org-4107	7	168	4-hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	7	169	,	,	,
en-wikipedia-org-4107	7	170	4-hydroxynorephedrine	4-hydroxynorephedrine	CD
en-wikipedia-org-4107	7	171	,	,	,
en-wikipedia-org-4107	7	172	4-hydroxyphenylacetone	4-hydroxyphenylacetone	CD
en-wikipedia-org-4107	7	173	,	,	,
en-wikipedia-org-4107	7	174	benzoic	benzoic	NNP
en-wikipedia-org-4107	7	175	acid	acid	NN
en-wikipedia-org-4107	7	176	,	,	,
en-wikipedia-org-4107	7	177	hippuric	hippuric	NN
en-wikipedia-org-4107	7	178	acid	acid	NN
en-wikipedia-org-4107	7	179	,	,	,
en-wikipedia-org-4107	7	180	norephedrine	norephedrine	NN
en-wikipedia-org-4107	7	181	,	,	,
en-wikipedia-org-4107	7	182	phenylacetone[6][7	phenylacetone[6][7	ADD
en-wikipedia-org-4107	7	183	]	]	-RRB-
en-wikipedia-org-4107	7	184	Onset	onset	NN
en-wikipedia-org-4107	7	185	of	of	IN
en-wikipedia-org-4107	7	186	action	action	NN
en-wikipedia-org-4107	7	187	IR	IR	NNP
en-wikipedia-org-4107	7	188	dosing	dose	VBG
en-wikipedia-org-4107	7	189	:	:	:
en-wikipedia-org-4107	7	190	30–60	30–60	CD
en-wikipedia-org-4107	7	191	 	  	_SP
en-wikipedia-org-4107	7	192	minutes[8	minutes[8	NNP
en-wikipedia-org-4107	7	193	]	]	-RRB-
en-wikipedia-org-4107	7	194	XR	XR	NNP
en-wikipedia-org-4107	7	195	dosing	dosing	NN
en-wikipedia-org-4107	7	196	:	:	:
en-wikipedia-org-4107	7	197	1.5–2	1.5–2	CD
en-wikipedia-org-4107	7	198	 	  	_SP
en-wikipedia-org-4107	7	199	hours[9][10	hours[9][10	NN
en-wikipedia-org-4107	7	200	]	]	-RRB-
en-wikipedia-org-4107	7	201	Elimination	elimination	NN
en-wikipedia-org-4107	7	202	half	half	JJ
en-wikipedia-org-4107	7	203	-	-	HYPH
en-wikipedia-org-4107	7	204	life	life	NN
en-wikipedia-org-4107	7	205	D	d	NN
en-wikipedia-org-4107	7	206	-	-	HYPH
en-wikipedia-org-4107	7	207	amph	amph	NN
en-wikipedia-org-4107	7	208	:	:	:
en-wikipedia-org-4107	7	209	9–11	9–11	JJ
en-wikipedia-org-4107	7	210	 	  	_SP
en-wikipedia-org-4107	7	211	hours[6][11	hours[6][11	JJ
en-wikipedia-org-4107	7	212	]	]	-RRB-
en-wikipedia-org-4107	7	213	L	L	NNP
en-wikipedia-org-4107	7	214	-	-	HYPH
en-wikipedia-org-4107	7	215	amph	amph	NN
en-wikipedia-org-4107	7	216	:	:	:
en-wikipedia-org-4107	7	217	11–14	11–14	NNP
en-wikipedia-org-4107	7	218	 	  	_SP
en-wikipedia-org-4107	7	219	hours[6][11	hours[6][11	JJ
en-wikipedia-org-4107	7	220	]	]	-RRB-
en-wikipedia-org-4107	7	221	pH	ph	JJ
en-wikipedia-org-4107	7	222	-	-	HYPH
en-wikipedia-org-4107	7	223	dependent	dependent	JJ
en-wikipedia-org-4107	7	224	:	:	:
en-wikipedia-org-4107	7	225	7–34	7–34	NN
en-wikipedia-org-4107	7	226	 	  	_SP
en-wikipedia-org-4107	7	227	hours[12	hours[12	NNP
en-wikipedia-org-4107	7	228	]	]	-RRB-
en-wikipedia-org-4107	7	229	Duration	duration	NN
en-wikipedia-org-4107	7	230	of	of	IN
en-wikipedia-org-4107	7	231	action	action	NN
en-wikipedia-org-4107	7	232	IR	IR	NNP
en-wikipedia-org-4107	7	233	dosing	dose	VBG
en-wikipedia-org-4107	7	234	:	:	:
en-wikipedia-org-4107	7	235	3–6	3–6	CD
en-wikipedia-org-4107	7	236	 	  	_SP
en-wikipedia-org-4107	7	237	hours[2][9][13	hours[2][9][13	NNS
en-wikipedia-org-4107	7	238	]	]	-RRB-
en-wikipedia-org-4107	7	239	XR	XR	NNP
en-wikipedia-org-4107	7	240	dosing	dosing	NN
en-wikipedia-org-4107	7	241	:	:	:
en-wikipedia-org-4107	7	242	8–12	8–12	NN
en-wikipedia-org-4107	7	243	 	  	_SP
en-wikipedia-org-4107	7	244	hours[2][9][13	hours[2][9][13	NNS
en-wikipedia-org-4107	7	245	]	]	-RRB-
en-wikipedia-org-4107	7	246	Excretion	Excretion	NNP
en-wikipedia-org-4107	7	247	Primarily	primarily	RB
en-wikipedia-org-4107	7	248	renal	renal	JJ
en-wikipedia-org-4107	7	249	;	;	:
en-wikipedia-org-4107	7	250	pH	ph	JJ
en-wikipedia-org-4107	7	251	-	-	HYPH
en-wikipedia-org-4107	7	252	dependent	dependent	JJ
en-wikipedia-org-4107	7	253	range	range	NN
en-wikipedia-org-4107	7	254	:	:	:
en-wikipedia-org-4107	7	255	1–75%[6	1–75%[6	CD
en-wikipedia-org-4107	7	256	]	]	-RRB-
en-wikipedia-org-4107	7	257	Identifiers	Identifiers	NNP
en-wikipedia-org-4107	7	258	IUPAC	IUPAC	NNP
en-wikipedia-org-4107	7	259	name	name	NN
en-wikipedia-org-4107	7	260	(	(	-LRB-
en-wikipedia-org-4107	7	261	RS)-1-phenylpropan-2-amine	rs)-1-phenylpropan-2-amine	CD
en-wikipedia-org-4107	7	262	CAS	CAS	NNP
en-wikipedia-org-4107	7	263	Number	Number	NNP
en-wikipedia-org-4107	7	264	300	300	CD
en-wikipedia-org-4107	7	265	-	-	HYPH
en-wikipedia-org-4107	7	266	62	62	CD
en-wikipedia-org-4107	7	267	-	-	SYM
en-wikipedia-org-4107	7	268	9	9	CD
en-wikipedia-org-4107	7	269	 	  	_SP
en-wikipedia-org-4107	7	270	Y	Y	NNP
en-wikipedia-org-4107	7	271	PubChem	PubChem	NNP
en-wikipedia-org-4107	7	272	CID	CID	NNP
en-wikipedia-org-4107	7	273	3007	3007	CD
en-wikipedia-org-4107	7	274	IUPHAR	IUPHAR	NNP
en-wikipedia-org-4107	7	275	/	/	SYM
en-wikipedia-org-4107	7	276	BPS	BPS	NNP
en-wikipedia-org-4107	7	277	4804	4804	CD
en-wikipedia-org-4107	7	278	DrugBank	DrugBank	NNP
en-wikipedia-org-4107	7	279	DB00182	db00182	NN
en-wikipedia-org-4107	7	280	 	  	_SP
en-wikipedia-org-4107	7	281	Y	Y	NNP
en-wikipedia-org-4107	7	282	ChemSpider	ChemSpider	NNP
en-wikipedia-org-4107	7	283	13852819	13852819	CD
en-wikipedia-org-4107	7	284	 	  	_SP
en-wikipedia-org-4107	7	285	Y	Y	NNP
en-wikipedia-org-4107	7	286	UNII	UNII	NNP
en-wikipedia-org-4107	7	287	CK833KGX7E	CK833KGX7E	NNP
en-wikipedia-org-4107	7	288	KEGG	KEGG	NNP
en-wikipedia-org-4107	7	289	D07445	D07445	VBZ
en-wikipedia-org-4107	7	290	 	  	_SP
en-wikipedia-org-4107	7	291	Y	Y	NNP
en-wikipedia-org-4107	7	292	ChEBI	ChEBI	NNP
en-wikipedia-org-4107	7	293	CHEBI:2679	chebi:2679	NN
en-wikipedia-org-4107	7	294	 	  	_SP
en-wikipedia-org-4107	7	295	Y	Y	NNP
en-wikipedia-org-4107	7	296	ChEMBL	chembl	NN
en-wikipedia-org-4107	7	297	ChEMBL405	chembl405	NN
en-wikipedia-org-4107	7	298	 	  	_SP
en-wikipedia-org-4107	7	299	Y	Y	NNP
en-wikipedia-org-4107	7	300	NIAID	NIAID	NNP
en-wikipedia-org-4107	7	301	ChemDB	ChemDB	NNP
en-wikipedia-org-4107	7	302	018564	018564	CD
en-wikipedia-org-4107	7	303	CompTox	CompTox	NNP
en-wikipedia-org-4107	7	304	Dashboard	Dashboard	NNP
en-wikipedia-org-4107	7	305	(	(	-LRB-
en-wikipedia-org-4107	7	306	EPA	EPA	NNP
en-wikipedia-org-4107	7	307	)	)	-RRB-
en-wikipedia-org-4107	7	308	DTXSID4022600	DTXSID4022600	NNP
en-wikipedia-org-4107	7	309	ECHA	ECHA	NNP
en-wikipedia-org-4107	7	310	InfoCard	InfoCard	NNP
en-wikipedia-org-4107	7	311	100.005.543	100.005.543	CD
en-wikipedia-org-4107	7	312	Chemical	chemical	NN
en-wikipedia-org-4107	7	313	and	and	CC
en-wikipedia-org-4107	7	314	physical	physical	JJ
en-wikipedia-org-4107	7	315	data	datum	NNS
en-wikipedia-org-4107	7	316	Formula	Formula	NNP
en-wikipedia-org-4107	7	317	C9H13N	C9H13N	NNP
en-wikipedia-org-4107	7	318	Molar	Molar	NNP
en-wikipedia-org-4107	7	319	mass	mass	NN
en-wikipedia-org-4107	7	320	135.210	135.210	CD
en-wikipedia-org-4107	7	321	 	  	_SP
en-wikipedia-org-4107	7	322	g·mol−1	g·mol−1	VB
en-wikipedia-org-4107	7	323	3D	3D	NNP
en-wikipedia-org-4107	7	324	model	model	NN
en-wikipedia-org-4107	7	325	(	(	-LRB-
en-wikipedia-org-4107	7	326	JSmol	JSmol	NNP
en-wikipedia-org-4107	7	327	)	)	-RRB-
en-wikipedia-org-4107	7	328	Interactive	interactive	JJ
en-wikipedia-org-4107	7	329	image	image	NN
en-wikipedia-org-4107	7	330	Chirality	Chirality	NNP
en-wikipedia-org-4107	7	331	Racemic	Racemic	NNP
en-wikipedia-org-4107	7	332	mixture[18	mixture[18	NNP
en-wikipedia-org-4107	7	333	]	]	-RRB-
en-wikipedia-org-4107	7	334	Density	density	NN
en-wikipedia-org-4107	7	335	.936	.936	CD
en-wikipedia-org-4107	7	336	 	  	_SP
en-wikipedia-org-4107	7	337	g	g	NN
en-wikipedia-org-4107	7	338	/	/	SYM
en-wikipedia-org-4107	7	339	cm3	cm3	NNS
en-wikipedia-org-4107	7	340	at	at	IN
en-wikipedia-org-4107	7	341	25	25	CD
en-wikipedia-org-4107	7	342	 	  	_SP
en-wikipedia-org-4107	7	343	°	°	NNS
en-wikipedia-org-4107	7	344	C[19	c[19	NN
en-wikipedia-org-4107	7	345	]	]	-RRB-
en-wikipedia-org-4107	7	346	Melting	melt	VBG
en-wikipedia-org-4107	7	347	point	point	NN
en-wikipedia-org-4107	7	348	11.3	11.3	CD
en-wikipedia-org-4107	7	349	 	  	_SP
en-wikipedia-org-4107	7	350	°	°	,
en-wikipedia-org-4107	7	351	C	C	NNP
en-wikipedia-org-4107	7	352	(	(	-LRB-
en-wikipedia-org-4107	7	353	52.3	52.3	CD
en-wikipedia-org-4107	7	354	 	  	_SP
en-wikipedia-org-4107	7	355	°	°	,
en-wikipedia-org-4107	7	356	F	F	NNP
en-wikipedia-org-4107	7	357	)	)	-RRB-
en-wikipedia-org-4107	7	358	(	(	-LRB-
en-wikipedia-org-4107	7	359	predicted)[20	predicted)[20	LS
en-wikipedia-org-4107	7	360	]	]	-RRB-
en-wikipedia-org-4107	7	361	Boiling	boiling	NN
en-wikipedia-org-4107	7	362	point	point	NN
en-wikipedia-org-4107	7	363	203	203	CD
en-wikipedia-org-4107	7	364	 	  	_SP
en-wikipedia-org-4107	7	365	°	°	,
en-wikipedia-org-4107	7	366	C	C	NNP
en-wikipedia-org-4107	7	367	(	(	-LRB-
en-wikipedia-org-4107	7	368	397	397	CD
en-wikipedia-org-4107	7	369	 	  	_SP
en-wikipedia-org-4107	7	370	°	°	,
en-wikipedia-org-4107	7	371	F	F	NNP
en-wikipedia-org-4107	7	372	)	)	-RRB-
en-wikipedia-org-4107	7	373	at	at	IN
en-wikipedia-org-4107	7	374	760	760	CD
en-wikipedia-org-4107	7	375	 	  	_SP
en-wikipedia-org-4107	7	376	mmHg[21	mmHg[21	NNP
en-wikipedia-org-4107	7	377	]	]	-RRB-
en-wikipedia-org-4107	7	378	SMILES	SMILES	NNP
en-wikipedia-org-4107	7	379	NC(CC1	NC(CC1	NNP
en-wikipedia-org-4107	7	380	=	=	SYM
en-wikipedia-org-4107	7	381	CC	cc	NN
en-wikipedia-org-4107	7	382	=	=	SYM
en-wikipedia-org-4107	7	383	CC	cc	NN
en-wikipedia-org-4107	7	384	=	=	:
en-wikipedia-org-4107	7	385	C1)C	C1)C	:
en-wikipedia-org-4107	7	386	InChI	InChI	NNP
en-wikipedia-org-4107	7	387	InChI=1S	InChI=1S	NNP
en-wikipedia-org-4107	7	388	/	/	NFP
en-wikipedia-org-4107	7	389	C9H13N	c9h13n	NN
en-wikipedia-org-4107	7	390	/	/	SYM
en-wikipedia-org-4107	7	391	c1	c1	NN
en-wikipedia-org-4107	7	392	-	-	HYPH
en-wikipedia-org-4107	7	393	8(10)7	8(10)7	CD
en-wikipedia-org-4107	7	394	-	-	HYPH
en-wikipedia-org-4107	7	395	9	9	CD
en-wikipedia-org-4107	7	396	-	-	HYPH
en-wikipedia-org-4107	7	397	5	5	CD
en-wikipedia-org-4107	7	398	-	-	HYPH
en-wikipedia-org-4107	7	399	3	3	CD
en-wikipedia-org-4107	7	400	-	-	HYPH
en-wikipedia-org-4107	7	401	2	2	CD
en-wikipedia-org-4107	7	402	-	-	HYPH
en-wikipedia-org-4107	7	403	4	4	CD
en-wikipedia-org-4107	7	404	-	-	HYPH
en-wikipedia-org-4107	7	405	6	6	CD
en-wikipedia-org-4107	7	406	-	-	HYPH
en-wikipedia-org-4107	7	407	9	9	CD
en-wikipedia-org-4107	7	408	/	/	SYM
en-wikipedia-org-4107	7	409	h2	h2	NNP
en-wikipedia-org-4107	7	410	-	-	HYPH
en-wikipedia-org-4107	7	411	6,8H,7,10H2,1H3	6,8h,7,10h2,1h3	NN
en-wikipedia-org-4107	7	412	 	  	_SP
en-wikipedia-org-4107	7	413	Y	Y	NNP
en-wikipedia-org-4107	7	414	Key	Key	NNP
en-wikipedia-org-4107	7	415	:	:	:
en-wikipedia-org-4107	7	416	KWTSXDURSIMDCE	KWTSXDURSIMDCE	NNP
en-wikipedia-org-4107	7	417	-	-	HYPH
en-wikipedia-org-4107	7	418	UHFFFAOYSA	UHFFFAOYSA	NNP
en-wikipedia-org-4107	7	419	-	-	HYPH
en-wikipedia-org-4107	7	420	N	n	NN
en-wikipedia-org-4107	7	421	 	  	_SP
en-wikipedia-org-4107	7	422	Y	Y	NNP
en-wikipedia-org-4107	7	423	  	  	_SP
en-wikipedia-org-4107	7	424	(	(	-LRB-
en-wikipedia-org-4107	7	425	verify	verify	VB
en-wikipedia-org-4107	7	426	)	)	-RRB-
en-wikipedia-org-4107	7	427	Amphetamine[note	amphetamine[note	CD
en-wikipedia-org-4107	7	428	2	2	CD
en-wikipedia-org-4107	7	429	]	]	-RRB-
en-wikipedia-org-4107	7	430	(	(	-LRB-
en-wikipedia-org-4107	7	431	contracted	contract	VBN
en-wikipedia-org-4107	7	432	from	from	IN
en-wikipedia-org-4107	7	433	alpha	alpha	NN
en-wikipedia-org-4107	7	434	-	-	HYPH
en-wikipedia-org-4107	7	435	methylphenethylamine	methylphenethylamine	NN
en-wikipedia-org-4107	7	436	)	)	-RRB-
en-wikipedia-org-4107	7	437	is	be	VBZ
en-wikipedia-org-4107	7	438	a	a	DT
en-wikipedia-org-4107	7	439	central	central	JJ
en-wikipedia-org-4107	7	440	nervous	nervous	JJ
en-wikipedia-org-4107	7	441	system	system	NN
en-wikipedia-org-4107	7	442	(	(	-LRB-
en-wikipedia-org-4107	7	443	CNS	cns	NN
en-wikipedia-org-4107	7	444	)	)	-RRB-
en-wikipedia-org-4107	7	445	stimulant	stimulant	NN
en-wikipedia-org-4107	7	446	marketed	market	VBN
en-wikipedia-org-4107	7	447	under	under	IN
en-wikipedia-org-4107	7	448	the	the	DT
en-wikipedia-org-4107	7	449	brand	brand	NN
en-wikipedia-org-4107	7	450	name	name	NN
en-wikipedia-org-4107	7	451	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	7	452	,	,	,
en-wikipedia-org-4107	7	453	among	among	IN
en-wikipedia-org-4107	7	454	others	other	NNS
en-wikipedia-org-4107	7	455	.	.	.
en-wikipedia-org-4107	8	1	It	-PRON-	PRP
en-wikipedia-org-4107	8	2	is	be	VBZ
en-wikipedia-org-4107	8	3	used	use	VBN
en-wikipedia-org-4107	8	4	in	in	IN
en-wikipedia-org-4107	8	5	the	the	DT
en-wikipedia-org-4107	8	6	treatment	treatment	NN
en-wikipedia-org-4107	8	7	of	of	IN
en-wikipedia-org-4107	8	8	attention	attention	NN
en-wikipedia-org-4107	8	9	deficit	deficit	NN
en-wikipedia-org-4107	8	10	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	8	11	disorder	disorder	NN
en-wikipedia-org-4107	8	12	(	(	-LRB-
en-wikipedia-org-4107	8	13	ADHD	ADHD	NNP
en-wikipedia-org-4107	8	14	)	)	-RRB-
en-wikipedia-org-4107	8	15	,	,	,
en-wikipedia-org-4107	8	16	narcolepsy	narcolepsy	NN
en-wikipedia-org-4107	8	17	,	,	,
en-wikipedia-org-4107	8	18	and	and	CC
en-wikipedia-org-4107	8	19	obesity	obesity	NN
en-wikipedia-org-4107	8	20	.	.	.
en-wikipedia-org-4107	9	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	9	2	was	be	VBD
en-wikipedia-org-4107	9	3	discovered	discover	VBN
en-wikipedia-org-4107	9	4	in	in	IN
en-wikipedia-org-4107	9	5	1887	1887	CD
en-wikipedia-org-4107	9	6	and	and	CC
en-wikipedia-org-4107	9	7	exists	exist	VBZ
en-wikipedia-org-4107	9	8	as	as	IN
en-wikipedia-org-4107	9	9	two	two	CD
en-wikipedia-org-4107	9	10	enantiomers:[note	enantiomers:[note	SYM
en-wikipedia-org-4107	9	11	3	3	CD
en-wikipedia-org-4107	9	12	]	]	-RRB-
en-wikipedia-org-4107	9	13	levoamphetamine	levoamphetamine	NN
en-wikipedia-org-4107	9	14	and	and	CC
en-wikipedia-org-4107	9	15	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	9	16	.	.	.
en-wikipedia-org-4107	10	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	10	2	properly	properly	RB
en-wikipedia-org-4107	10	3	refers	refer	VBZ
en-wikipedia-org-4107	10	4	to	to	IN
en-wikipedia-org-4107	10	5	a	a	DT
en-wikipedia-org-4107	10	6	specific	specific	JJ
en-wikipedia-org-4107	10	7	chemical	chemical	NN
en-wikipedia-org-4107	10	8	,	,	,
en-wikipedia-org-4107	10	9	the	the	DT
en-wikipedia-org-4107	10	10	racemic	racemic	JJ
en-wikipedia-org-4107	10	11	free	free	JJ
en-wikipedia-org-4107	10	12	base	base	NN
en-wikipedia-org-4107	10	13	,	,	,
en-wikipedia-org-4107	10	14	which	which	WDT
en-wikipedia-org-4107	10	15	is	be	VBZ
en-wikipedia-org-4107	10	16	equal	equal	JJ
en-wikipedia-org-4107	10	17	parts	part	NNS
en-wikipedia-org-4107	10	18	of	of	IN
en-wikipedia-org-4107	10	19	the	the	DT
en-wikipedia-org-4107	10	20	two	two	CD
en-wikipedia-org-4107	10	21	enantiomers	enantiomer	NNS
en-wikipedia-org-4107	10	22	,	,	,
en-wikipedia-org-4107	10	23	levoamphetamine	levoamphetamine	NN
en-wikipedia-org-4107	10	24	and	and	CC
en-wikipedia-org-4107	10	25	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	10	26	,	,	,
en-wikipedia-org-4107	10	27	in	in	IN
en-wikipedia-org-4107	10	28	their	-PRON-	PRP$
en-wikipedia-org-4107	10	29	pure	pure	JJ
en-wikipedia-org-4107	10	30	amine	amine	NN
en-wikipedia-org-4107	10	31	forms	form	NNS
en-wikipedia-org-4107	10	32	.	.	.
en-wikipedia-org-4107	11	1	The	the	DT
en-wikipedia-org-4107	11	2	term	term	NN
en-wikipedia-org-4107	11	3	is	be	VBZ
en-wikipedia-org-4107	11	4	frequently	frequently	RB
en-wikipedia-org-4107	11	5	used	use	VBN
en-wikipedia-org-4107	11	6	informally	informally	RB
en-wikipedia-org-4107	11	7	to	to	TO
en-wikipedia-org-4107	11	8	refer	refer	VB
en-wikipedia-org-4107	11	9	to	to	IN
en-wikipedia-org-4107	11	10	any	any	DT
en-wikipedia-org-4107	11	11	combination	combination	NN
en-wikipedia-org-4107	11	12	of	of	IN
en-wikipedia-org-4107	11	13	the	the	DT
en-wikipedia-org-4107	11	14	enantiomers	enantiomer	NNS
en-wikipedia-org-4107	11	15	,	,	,
en-wikipedia-org-4107	11	16	or	or	CC
en-wikipedia-org-4107	11	17	to	to	IN
en-wikipedia-org-4107	11	18	either	either	DT
en-wikipedia-org-4107	11	19	of	of	IN
en-wikipedia-org-4107	11	20	them	-PRON-	PRP
en-wikipedia-org-4107	11	21	alone	alone	JJ
en-wikipedia-org-4107	11	22	.	.	.
en-wikipedia-org-4107	12	1	Historically	historically	RB
en-wikipedia-org-4107	12	2	,	,	,
en-wikipedia-org-4107	12	3	it	-PRON-	PRP
en-wikipedia-org-4107	12	4	has	have	VBZ
en-wikipedia-org-4107	12	5	been	be	VBN
en-wikipedia-org-4107	12	6	used	use	VBN
en-wikipedia-org-4107	12	7	to	to	TO
en-wikipedia-org-4107	12	8	treat	treat	VB
en-wikipedia-org-4107	12	9	nasal	nasal	NN
en-wikipedia-org-4107	12	10	congestion	congestion	NN
en-wikipedia-org-4107	12	11	and	and	CC
en-wikipedia-org-4107	12	12	depression	depression	NN
en-wikipedia-org-4107	12	13	.	.	.
en-wikipedia-org-4107	13	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	13	2	is	be	VBZ
en-wikipedia-org-4107	13	3	also	also	RB
en-wikipedia-org-4107	13	4	used	use	VBN
en-wikipedia-org-4107	13	5	as	as	IN
en-wikipedia-org-4107	13	6	an	an	DT
en-wikipedia-org-4107	13	7	athletic	athletic	JJ
en-wikipedia-org-4107	13	8	performance	performance	NN
en-wikipedia-org-4107	13	9	enhancer	enhancer	NN
en-wikipedia-org-4107	13	10	and	and	CC
en-wikipedia-org-4107	13	11	cognitive	cognitive	JJ
en-wikipedia-org-4107	13	12	enhancer	enhancer	NN
en-wikipedia-org-4107	13	13	,	,	,
en-wikipedia-org-4107	13	14	and	and	CC
en-wikipedia-org-4107	13	15	recreationally	recreationally	RB
en-wikipedia-org-4107	13	16	as	as	IN
en-wikipedia-org-4107	13	17	an	an	DT
en-wikipedia-org-4107	13	18	aphrodisiac	aphrodisiac	NN
en-wikipedia-org-4107	13	19	and	and	CC
en-wikipedia-org-4107	13	20	euphoriant	euphoriant	JJ
en-wikipedia-org-4107	13	21	.	.	.
en-wikipedia-org-4107	14	1	It	-PRON-	PRP
en-wikipedia-org-4107	14	2	is	be	VBZ
en-wikipedia-org-4107	14	3	a	a	DT
en-wikipedia-org-4107	14	4	prescription	prescription	NN
en-wikipedia-org-4107	14	5	drug	drug	NN
en-wikipedia-org-4107	14	6	in	in	IN
en-wikipedia-org-4107	14	7	many	many	JJ
en-wikipedia-org-4107	14	8	countries	country	NNS
en-wikipedia-org-4107	14	9	,	,	,
en-wikipedia-org-4107	14	10	and	and	CC
en-wikipedia-org-4107	14	11	unauthorized	unauthorized	JJ
en-wikipedia-org-4107	14	12	possession	possession	NN
en-wikipedia-org-4107	14	13	and	and	CC
en-wikipedia-org-4107	14	14	distribution	distribution	NN
en-wikipedia-org-4107	14	15	of	of	IN
en-wikipedia-org-4107	14	16	amphetamine	amphetamine	NN
en-wikipedia-org-4107	14	17	are	be	VBP
en-wikipedia-org-4107	14	18	often	often	RB
en-wikipedia-org-4107	14	19	tightly	tightly	RB
en-wikipedia-org-4107	14	20	controlled	control	VBN
en-wikipedia-org-4107	14	21	due	due	IN
en-wikipedia-org-4107	14	22	to	to	IN
en-wikipedia-org-4107	14	23	the	the	DT
en-wikipedia-org-4107	14	24	significant	significant	JJ
en-wikipedia-org-4107	14	25	health	health	NN
en-wikipedia-org-4107	14	26	risks	risk	NNS
en-wikipedia-org-4107	14	27	associated	associate	VBN
en-wikipedia-org-4107	14	28	with	with	IN
en-wikipedia-org-4107	14	29	recreational	recreational	JJ
en-wikipedia-org-4107	14	30	use	use	NN
en-wikipedia-org-4107	14	31	.	.	.
en-wikipedia-org-4107	15	1	[	[	-LRB-
en-wikipedia-org-4107	15	2	sources	source	NNS
en-wikipedia-org-4107	15	3	1	1	LS
en-wikipedia-org-4107	15	4	]	]	-RRB-
en-wikipedia-org-4107	15	5	The	the	DT
en-wikipedia-org-4107	15	6	first	first	JJ
en-wikipedia-org-4107	15	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	15	8	pharmaceutical	pharmaceutical	NN
en-wikipedia-org-4107	15	9	was	be	VBD
en-wikipedia-org-4107	15	10	Benzedrine	Benzedrine	NNP
en-wikipedia-org-4107	15	11	,	,	,
en-wikipedia-org-4107	15	12	a	a	DT
en-wikipedia-org-4107	15	13	brand	brand	NN
en-wikipedia-org-4107	15	14	which	which	WDT
en-wikipedia-org-4107	15	15	was	be	VBD
en-wikipedia-org-4107	15	16	used	use	VBN
en-wikipedia-org-4107	15	17	to	to	TO
en-wikipedia-org-4107	15	18	treat	treat	VB
en-wikipedia-org-4107	15	19	a	a	DT
en-wikipedia-org-4107	15	20	variety	variety	NN
en-wikipedia-org-4107	15	21	of	of	IN
en-wikipedia-org-4107	15	22	conditions	condition	NNS
en-wikipedia-org-4107	15	23	.	.	.
en-wikipedia-org-4107	16	1	Currently	currently	RB
en-wikipedia-org-4107	16	2	,	,	,
en-wikipedia-org-4107	16	3	pharmaceutical	pharmaceutical	JJ
en-wikipedia-org-4107	16	4	amphetamine	amphetamine	NN
en-wikipedia-org-4107	16	5	is	be	VBZ
en-wikipedia-org-4107	16	6	prescribed	prescribe	VBN
en-wikipedia-org-4107	16	7	as	as	IN
en-wikipedia-org-4107	16	8	racemic	racemic	JJ
en-wikipedia-org-4107	16	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	16	10	,	,	,
en-wikipedia-org-4107	16	11	Adderall,[note	Adderall,[note	NNP
en-wikipedia-org-4107	16	12	4	4	CD
en-wikipedia-org-4107	16	13	]	]	-RRB-
en-wikipedia-org-4107	16	14	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	16	15	,	,	,
en-wikipedia-org-4107	16	16	or	or	CC
en-wikipedia-org-4107	16	17	the	the	DT
en-wikipedia-org-4107	16	18	inactive	inactive	JJ
en-wikipedia-org-4107	16	19	prodrug	prodrug	NN
en-wikipedia-org-4107	16	20	lisdexamfetamine	lisdexamfetamine	NN
en-wikipedia-org-4107	16	21	.	.	.
en-wikipedia-org-4107	17	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	17	2	increases	increase	VBZ
en-wikipedia-org-4107	17	3	monoamine	monoamine	NN
en-wikipedia-org-4107	17	4	and	and	CC
en-wikipedia-org-4107	17	5	excitatory	excitatory	NN
en-wikipedia-org-4107	17	6	neurotransmission	neurotransmission	NN
en-wikipedia-org-4107	17	7	in	in	IN
en-wikipedia-org-4107	17	8	the	the	DT
en-wikipedia-org-4107	17	9	brain	brain	NN
en-wikipedia-org-4107	17	10	,	,	,
en-wikipedia-org-4107	17	11	with	with	IN
en-wikipedia-org-4107	17	12	its	-PRON-	PRP$
en-wikipedia-org-4107	17	13	most	most	RBS
en-wikipedia-org-4107	17	14	pronounced	pronounced	JJ
en-wikipedia-org-4107	17	15	effects	effect	NNS
en-wikipedia-org-4107	17	16	targeting	target	VBG
en-wikipedia-org-4107	17	17	the	the	DT
en-wikipedia-org-4107	17	18	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	17	19	and	and	CC
en-wikipedia-org-4107	17	20	dopamine	dopamine	NN
en-wikipedia-org-4107	17	21	neurotransmitter	neurotransmitter	NN
en-wikipedia-org-4107	17	22	systems	system	NNS
en-wikipedia-org-4107	17	23	.	.	.
en-wikipedia-org-4107	18	1	[	[	-LRB-
en-wikipedia-org-4107	18	2	sources	source	NNS
en-wikipedia-org-4107	18	3	2	2	CD
en-wikipedia-org-4107	18	4	]	]	-RRB-
en-wikipedia-org-4107	18	5	At	at	IN
en-wikipedia-org-4107	18	6	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	18	7	doses	dose	NNS
en-wikipedia-org-4107	18	8	,	,	,
en-wikipedia-org-4107	18	9	amphetamine	amphetamine	VB
en-wikipedia-org-4107	18	10	causes	cause	VBZ
en-wikipedia-org-4107	18	11	emotional	emotional	JJ
en-wikipedia-org-4107	18	12	and	and	CC
en-wikipedia-org-4107	18	13	cognitive	cognitive	JJ
en-wikipedia-org-4107	18	14	effects	effect	NNS
en-wikipedia-org-4107	18	15	such	such	JJ
en-wikipedia-org-4107	18	16	as	as	IN
en-wikipedia-org-4107	18	17	euphoria	euphoria	NN
en-wikipedia-org-4107	18	18	,	,	,
en-wikipedia-org-4107	18	19	change	change	NN
en-wikipedia-org-4107	18	20	in	in	IN
en-wikipedia-org-4107	18	21	desire	desire	NN
en-wikipedia-org-4107	18	22	for	for	IN
en-wikipedia-org-4107	18	23	sex	sex	NN
en-wikipedia-org-4107	18	24	,	,	,
en-wikipedia-org-4107	18	25	increased	increase	VBN
en-wikipedia-org-4107	18	26	wakefulness	wakefulness	NN
en-wikipedia-org-4107	18	27	,	,	,
en-wikipedia-org-4107	18	28	and	and	CC
en-wikipedia-org-4107	18	29	improved	improve	VBD
en-wikipedia-org-4107	18	30	cognitive	cognitive	JJ
en-wikipedia-org-4107	18	31	control	control	NN
en-wikipedia-org-4107	18	32	.	.	.
en-wikipedia-org-4107	19	1	It	-PRON-	PRP
en-wikipedia-org-4107	19	2	induces	induce	VBZ
en-wikipedia-org-4107	19	3	physical	physical	JJ
en-wikipedia-org-4107	19	4	effects	effect	NNS
en-wikipedia-org-4107	19	5	such	such	JJ
en-wikipedia-org-4107	19	6	as	as	IN
en-wikipedia-org-4107	19	7	improved	improve	VBN
en-wikipedia-org-4107	19	8	reaction	reaction	NN
en-wikipedia-org-4107	19	9	time	time	NN
en-wikipedia-org-4107	19	10	,	,	,
en-wikipedia-org-4107	19	11	fatigue	fatigue	NN
en-wikipedia-org-4107	19	12	resistance	resistance	NN
en-wikipedia-org-4107	19	13	,	,	,
en-wikipedia-org-4107	19	14	and	and	CC
en-wikipedia-org-4107	19	15	increased	increase	VBN
en-wikipedia-org-4107	19	16	muscle	muscle	NN
en-wikipedia-org-4107	19	17	strength	strength	NN
en-wikipedia-org-4107	19	18	.	.	.
en-wikipedia-org-4107	20	1	Larger	large	JJR
en-wikipedia-org-4107	20	2	doses	dose	NNS
en-wikipedia-org-4107	20	3	of	of	IN
en-wikipedia-org-4107	20	4	amphetamine	amphetamine	NN
en-wikipedia-org-4107	20	5	may	may	MD
en-wikipedia-org-4107	20	6	impair	impair	VB
en-wikipedia-org-4107	20	7	cognitive	cognitive	JJ
en-wikipedia-org-4107	20	8	function	function	NN
en-wikipedia-org-4107	20	9	and	and	CC
en-wikipedia-org-4107	20	10	induce	induce	VBP
en-wikipedia-org-4107	20	11	rapid	rapid	JJ
en-wikipedia-org-4107	20	12	muscle	muscle	NN
en-wikipedia-org-4107	20	13	breakdown	breakdown	NN
en-wikipedia-org-4107	20	14	.	.	.
en-wikipedia-org-4107	21	1	Addiction	addiction	NN
en-wikipedia-org-4107	21	2	is	be	VBZ
en-wikipedia-org-4107	21	3	a	a	DT
en-wikipedia-org-4107	21	4	serious	serious	JJ
en-wikipedia-org-4107	21	5	risk	risk	NN
en-wikipedia-org-4107	21	6	with	with	IN
en-wikipedia-org-4107	21	7	heavy	heavy	JJ
en-wikipedia-org-4107	21	8	recreational	recreational	JJ
en-wikipedia-org-4107	21	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	21	10	use	use	NN
en-wikipedia-org-4107	21	11	,	,	,
en-wikipedia-org-4107	21	12	but	but	CC
en-wikipedia-org-4107	21	13	is	be	VBZ
en-wikipedia-org-4107	21	14	unlikely	unlikely	JJ
en-wikipedia-org-4107	21	15	to	to	TO
en-wikipedia-org-4107	21	16	occur	occur	VB
en-wikipedia-org-4107	21	17	from	from	IN
en-wikipedia-org-4107	21	18	long	long	JJ
en-wikipedia-org-4107	21	19	-	-	HYPH
en-wikipedia-org-4107	21	20	term	term	NN
en-wikipedia-org-4107	21	21	medical	medical	JJ
en-wikipedia-org-4107	21	22	use	use	NN
en-wikipedia-org-4107	21	23	at	at	IN
en-wikipedia-org-4107	21	24	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	21	25	doses	dose	NNS
en-wikipedia-org-4107	21	26	.	.	.
en-wikipedia-org-4107	22	1	Very	very	RB
en-wikipedia-org-4107	22	2	high	high	JJ
en-wikipedia-org-4107	22	3	doses	dose	NNS
en-wikipedia-org-4107	22	4	can	can	MD
en-wikipedia-org-4107	22	5	result	result	VB
en-wikipedia-org-4107	22	6	in	in	IN
en-wikipedia-org-4107	22	7	psychosis	psychosis	NN
en-wikipedia-org-4107	22	8	(	(	-LRB-
en-wikipedia-org-4107	22	9	e.g.	e.g.	RB
en-wikipedia-org-4107	22	10	,	,	,
en-wikipedia-org-4107	22	11	delusions	delusion	NNS
en-wikipedia-org-4107	22	12	and	and	CC
en-wikipedia-org-4107	22	13	paranoia	paranoia	NN
en-wikipedia-org-4107	22	14	)	)	-RRB-
en-wikipedia-org-4107	22	15	which	which	WDT
en-wikipedia-org-4107	22	16	rarely	rarely	RB
en-wikipedia-org-4107	22	17	occurs	occur	VBZ
en-wikipedia-org-4107	22	18	at	at	IN
en-wikipedia-org-4107	22	19	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	22	20	doses	dose	NNS
en-wikipedia-org-4107	22	21	even	even	RB
en-wikipedia-org-4107	22	22	during	during	IN
en-wikipedia-org-4107	22	23	long	long	JJ
en-wikipedia-org-4107	22	24	-	-	HYPH
en-wikipedia-org-4107	22	25	term	term	NN
en-wikipedia-org-4107	22	26	use	use	NN
en-wikipedia-org-4107	22	27	.	.	.
en-wikipedia-org-4107	23	1	Recreational	recreational	JJ
en-wikipedia-org-4107	23	2	doses	dose	NNS
en-wikipedia-org-4107	23	3	are	be	VBP
en-wikipedia-org-4107	23	4	generally	generally	RB
en-wikipedia-org-4107	23	5	much	much	RB
en-wikipedia-org-4107	23	6	larger	large	JJR
en-wikipedia-org-4107	23	7	than	than	IN
en-wikipedia-org-4107	23	8	prescribed	prescribe	VBN
en-wikipedia-org-4107	23	9	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	23	10	doses	dose	NNS
en-wikipedia-org-4107	23	11	and	and	CC
en-wikipedia-org-4107	23	12	carry	carry	VB
en-wikipedia-org-4107	23	13	a	a	DT
en-wikipedia-org-4107	23	14	far	far	RB
en-wikipedia-org-4107	23	15	greater	great	JJR
en-wikipedia-org-4107	23	16	risk	risk	NN
en-wikipedia-org-4107	23	17	of	of	IN
en-wikipedia-org-4107	23	18	serious	serious	JJ
en-wikipedia-org-4107	23	19	side	side	NN
en-wikipedia-org-4107	23	20	effects	effect	NNS
en-wikipedia-org-4107	23	21	.	.	.
en-wikipedia-org-4107	24	1	[	[	-LRB-
en-wikipedia-org-4107	24	2	sources	source	NNS
en-wikipedia-org-4107	24	3	3	3	LS
en-wikipedia-org-4107	24	4	]	]	-RRB-
en-wikipedia-org-4107	24	5	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	24	6	belongs	belong	VBZ
en-wikipedia-org-4107	24	7	to	to	IN
en-wikipedia-org-4107	24	8	the	the	DT
en-wikipedia-org-4107	24	9	phenethylamine	phenethylamine	NN
en-wikipedia-org-4107	24	10	class	class	NN
en-wikipedia-org-4107	24	11	.	.	.
en-wikipedia-org-4107	25	1	It	-PRON-	PRP
en-wikipedia-org-4107	25	2	is	be	VBZ
en-wikipedia-org-4107	25	3	also	also	RB
en-wikipedia-org-4107	25	4	the	the	DT
en-wikipedia-org-4107	25	5	parent	parent	NN
en-wikipedia-org-4107	25	6	compound	compound	NN
en-wikipedia-org-4107	25	7	of	of	IN
en-wikipedia-org-4107	25	8	its	-PRON-	PRP$
en-wikipedia-org-4107	25	9	own	own	JJ
en-wikipedia-org-4107	25	10	structural	structural	JJ
en-wikipedia-org-4107	25	11	class	class	NN
en-wikipedia-org-4107	25	12	,	,	,
en-wikipedia-org-4107	25	13	the	the	DT
en-wikipedia-org-4107	25	14	substituted	substitute	VBN
en-wikipedia-org-4107	25	15	amphetamines,[note	amphetamines,[note	ADD
en-wikipedia-org-4107	25	16	5	5	CD
en-wikipedia-org-4107	25	17	]	]	-RRB-
en-wikipedia-org-4107	25	18	which	which	WDT
en-wikipedia-org-4107	25	19	includes	include	VBZ
en-wikipedia-org-4107	25	20	prominent	prominent	JJ
en-wikipedia-org-4107	25	21	substances	substance	NNS
en-wikipedia-org-4107	25	22	such	such	JJ
en-wikipedia-org-4107	25	23	as	as	IN
en-wikipedia-org-4107	25	24	bupropion	bupropion	NN
en-wikipedia-org-4107	25	25	,	,	,
en-wikipedia-org-4107	25	26	cathinone	cathinone	NN
en-wikipedia-org-4107	25	27	,	,	,
en-wikipedia-org-4107	25	28	MDMA	mdma	NN
en-wikipedia-org-4107	25	29	,	,	,
en-wikipedia-org-4107	25	30	and	and	CC
en-wikipedia-org-4107	25	31	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	25	32	.	.	.
en-wikipedia-org-4107	26	1	As	as	IN
en-wikipedia-org-4107	26	2	a	a	DT
en-wikipedia-org-4107	26	3	member	member	NN
en-wikipedia-org-4107	26	4	of	of	IN
en-wikipedia-org-4107	26	5	the	the	DT
en-wikipedia-org-4107	26	6	phenethylamine	phenethylamine	NN
en-wikipedia-org-4107	26	7	class	class	NN
en-wikipedia-org-4107	26	8	,	,	,
en-wikipedia-org-4107	26	9	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	26	10	is	be	VBZ
en-wikipedia-org-4107	26	11	also	also	RB
en-wikipedia-org-4107	26	12	chemically	chemically	RB
en-wikipedia-org-4107	26	13	related	relate	VBN
en-wikipedia-org-4107	26	14	to	to	IN
en-wikipedia-org-4107	26	15	the	the	DT
en-wikipedia-org-4107	26	16	naturally	naturally	RB
en-wikipedia-org-4107	26	17	occurring	occur	VBG
en-wikipedia-org-4107	26	18	trace	trace	NN
en-wikipedia-org-4107	26	19	amine	amine	NN
en-wikipedia-org-4107	26	20	neuromodulators	neuromodulator	NNS
en-wikipedia-org-4107	26	21	,	,	,
en-wikipedia-org-4107	26	22	specifically	specifically	RB
en-wikipedia-org-4107	26	23	phenethylamine	phenethylamine	VB
en-wikipedia-org-4107	26	24	and	and	CC
en-wikipedia-org-4107	26	25	N	N	NNP
en-wikipedia-org-4107	26	26	-	-	HYPH
en-wikipedia-org-4107	26	27	methylphenethylamine	methylphenethylamine	NN
en-wikipedia-org-4107	26	28	,	,	,
en-wikipedia-org-4107	26	29	both	both	DT
en-wikipedia-org-4107	26	30	of	of	IN
en-wikipedia-org-4107	26	31	which	which	WDT
en-wikipedia-org-4107	26	32	are	be	VBP
en-wikipedia-org-4107	26	33	produced	produce	VBN
en-wikipedia-org-4107	26	34	within	within	IN
en-wikipedia-org-4107	26	35	the	the	DT
en-wikipedia-org-4107	26	36	human	human	JJ
en-wikipedia-org-4107	26	37	body	body	NN
en-wikipedia-org-4107	26	38	.	.	.
en-wikipedia-org-4107	27	1	Phenethylamine	Phenethylamine	NNP
en-wikipedia-org-4107	27	2	is	be	VBZ
en-wikipedia-org-4107	27	3	the	the	DT
en-wikipedia-org-4107	27	4	parent	parent	NN
en-wikipedia-org-4107	27	5	compound	compound	NN
en-wikipedia-org-4107	27	6	of	of	IN
en-wikipedia-org-4107	27	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	27	8	,	,	,
en-wikipedia-org-4107	27	9	while	while	IN
en-wikipedia-org-4107	27	10	N	n	CD
en-wikipedia-org-4107	27	11	-	-	HYPH
en-wikipedia-org-4107	27	12	methylphenethylamine	methylphenethylamine	NN
en-wikipedia-org-4107	27	13	is	be	VBZ
en-wikipedia-org-4107	27	14	a	a	DT
en-wikipedia-org-4107	27	15	positional	positional	JJ
en-wikipedia-org-4107	27	16	isomer	isomer	NN
en-wikipedia-org-4107	27	17	of	of	IN
en-wikipedia-org-4107	27	18	amphetamine	amphetamine	NN
en-wikipedia-org-4107	27	19	that	that	WDT
en-wikipedia-org-4107	27	20	differs	differ	VBZ
en-wikipedia-org-4107	27	21	only	only	RB
en-wikipedia-org-4107	27	22	in	in	IN
en-wikipedia-org-4107	27	23	the	the	DT
en-wikipedia-org-4107	27	24	placement	placement	NN
en-wikipedia-org-4107	27	25	of	of	IN
en-wikipedia-org-4107	27	26	the	the	DT
en-wikipedia-org-4107	27	27	methyl	methyl	NN
en-wikipedia-org-4107	27	28	group	group	NN
en-wikipedia-org-4107	27	29	.	.	.
en-wikipedia-org-4107	28	1	[	[	-LRB-
en-wikipedia-org-4107	28	2	sources	source	NNS
en-wikipedia-org-4107	28	3	4	4	LS
en-wikipedia-org-4107	28	4	]	]	-RRB-
en-wikipedia-org-4107	28	5	Contents	content	NNS
en-wikipedia-org-4107	28	6	1	1	CD
en-wikipedia-org-4107	28	7	Uses	use	NNS
en-wikipedia-org-4107	28	8	1.1	1.1	CD
en-wikipedia-org-4107	28	9	Medical	medical	JJ
en-wikipedia-org-4107	28	10	1.2	1.2	CD
en-wikipedia-org-4107	28	11	Enhancing	enhance	VBG
en-wikipedia-org-4107	28	12	performance	performance	NN
en-wikipedia-org-4107	28	13	1.2.1	1.2.1	CD
en-wikipedia-org-4107	28	14	Cognitive	cognitive	JJ
en-wikipedia-org-4107	28	15	performance	performance	NN
en-wikipedia-org-4107	28	16	1.2.2	1.2.2	CD
en-wikipedia-org-4107	28	17	Physical	physical	JJ
en-wikipedia-org-4107	28	18	performance	performance	NN
en-wikipedia-org-4107	28	19	2	2	CD
en-wikipedia-org-4107	28	20	Contraindications	contraindication	NNS
en-wikipedia-org-4107	28	21	3	3	CD
en-wikipedia-org-4107	28	22	Adverse	adverse	JJ
en-wikipedia-org-4107	28	23	effects	effect	NNS
en-wikipedia-org-4107	28	24	3.1	3.1	CD
en-wikipedia-org-4107	28	25	Physical	Physical	NNP
en-wikipedia-org-4107	28	26	3.2	3.2	CD
en-wikipedia-org-4107	28	27	Psychological	Psychological	NNP
en-wikipedia-org-4107	28	28	3.3	3.3	CD
en-wikipedia-org-4107	28	29	Reinforcement	Reinforcement	NNP
en-wikipedia-org-4107	28	30	disorders	disorder	VBZ
en-wikipedia-org-4107	28	31	3.3.1	3.3.1	CD
en-wikipedia-org-4107	28	32	Addiction	addiction	NN
en-wikipedia-org-4107	28	33	3.3.2	3.3.2	CD
en-wikipedia-org-4107	28	34	Biomolecular	Biomolecular	NNP
en-wikipedia-org-4107	28	35	mechanisms	mechanism	NNS
en-wikipedia-org-4107	28	36	3.3.2.1	3.3.2.1	CD
en-wikipedia-org-4107	28	37	Pharmacological	pharmacological	JJ
en-wikipedia-org-4107	28	38	treatments	treatment	NNS
en-wikipedia-org-4107	28	39	3.3.2.2	3.3.2.2	CD
en-wikipedia-org-4107	28	40	Behavioral	behavioral	JJ
en-wikipedia-org-4107	28	41	treatments	treatment	NNS
en-wikipedia-org-4107	28	42	3.3.3	3.3.3	CD
en-wikipedia-org-4107	28	43	Dependence	dependence	NN
en-wikipedia-org-4107	28	44	and	and	CC
en-wikipedia-org-4107	28	45	withdrawal	withdrawal	NN
en-wikipedia-org-4107	28	46	4	4	CD
en-wikipedia-org-4107	28	47	Overdose	overdose	NN
en-wikipedia-org-4107	28	48	4.1	4.1	CD
en-wikipedia-org-4107	28	49	Toxicity	Toxicity	NNP
en-wikipedia-org-4107	28	50	4.2	4.2	CD
en-wikipedia-org-4107	28	51	Psychosis	Psychosis	NNP
en-wikipedia-org-4107	28	52	5	5	CD
en-wikipedia-org-4107	28	53	Drug	Drug	NNP
en-wikipedia-org-4107	28	54	interactions	interaction	NNS
en-wikipedia-org-4107	28	55	6	6	CD
en-wikipedia-org-4107	28	56	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	28	57	6.1	6.1	CD
en-wikipedia-org-4107	28	58	Pharmacodynamics	Pharmacodynamics	NNP
en-wikipedia-org-4107	28	59	6.1.1	6.1.1	NNP
en-wikipedia-org-4107	28	60	Dopamine	Dopamine	NNP
en-wikipedia-org-4107	28	61	6.1.2	6.1.2	NNP
en-wikipedia-org-4107	28	62	Norepinephrine	Norepinephrine	NNP
en-wikipedia-org-4107	28	63	6.1.3	6.1.3	NNP
en-wikipedia-org-4107	28	64	Serotonin	Serotonin	NNP
en-wikipedia-org-4107	28	65	6.1.4	6.1.4	CD
en-wikipedia-org-4107	28	66	Other	other	JJ
en-wikipedia-org-4107	28	67	neurotransmitters	neurotransmitter	NNS
en-wikipedia-org-4107	28	68	,	,	,
en-wikipedia-org-4107	28	69	peptides	peptide	NNS
en-wikipedia-org-4107	28	70	,	,	,
en-wikipedia-org-4107	28	71	hormones	hormone	NNS
en-wikipedia-org-4107	28	72	,	,	,
en-wikipedia-org-4107	28	73	and	and	CC
en-wikipedia-org-4107	28	74	enzymes	enzyme	VBZ
en-wikipedia-org-4107	28	75	6.2	6.2	CD
en-wikipedia-org-4107	28	76	Pharmacokinetics	Pharmacokinetics	NNPS
en-wikipedia-org-4107	28	77	6.3	6.3	CD
en-wikipedia-org-4107	28	78	Pharmacomicrobiomics	pharmacomicrobiomic	NNS
en-wikipedia-org-4107	28	79	6.4	6.4	CD
en-wikipedia-org-4107	28	80	Related	related	JJ
en-wikipedia-org-4107	28	81	endogenous	endogenous	JJ
en-wikipedia-org-4107	28	82	compounds	compound	NNS
en-wikipedia-org-4107	28	83	7	7	CD
en-wikipedia-org-4107	28	84	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	28	85	7.1	7.1	CD
en-wikipedia-org-4107	28	86	Substituted	substitute	VBN
en-wikipedia-org-4107	28	87	derivatives	derivative	NNS
en-wikipedia-org-4107	28	88	7.2	7.2	CD
en-wikipedia-org-4107	28	89	Synthesis	synthesis	NN
en-wikipedia-org-4107	28	90	7.3	7.3	CD
en-wikipedia-org-4107	28	91	Detection	detection	NN
en-wikipedia-org-4107	28	92	in	in	IN
en-wikipedia-org-4107	28	93	body	body	NN
en-wikipedia-org-4107	28	94	fluids	fluid	VBZ
en-wikipedia-org-4107	28	95	8	8	CD
en-wikipedia-org-4107	28	96	History	history	NN
en-wikipedia-org-4107	28	97	,	,	,
en-wikipedia-org-4107	28	98	society	society	NN
en-wikipedia-org-4107	28	99	,	,	,
en-wikipedia-org-4107	28	100	and	and	CC
en-wikipedia-org-4107	28	101	culture	culture	NN
en-wikipedia-org-4107	28	102	8.1	8.1	CD
en-wikipedia-org-4107	28	103	Legal	legal	JJ
en-wikipedia-org-4107	28	104	status	status	NN
en-wikipedia-org-4107	28	105	8.2	8.2	CD
en-wikipedia-org-4107	28	106	Pharmaceutical	pharmaceutical	JJ
en-wikipedia-org-4107	28	107	products	product	NNS
en-wikipedia-org-4107	28	108	9	9	CD
en-wikipedia-org-4107	28	109	Notes	note	NNS
en-wikipedia-org-4107	28	110	10	10	CD
en-wikipedia-org-4107	28	111	Reference	reference	NN
en-wikipedia-org-4107	28	112	notes	note	VBZ
en-wikipedia-org-4107	28	113	11	11	CD
en-wikipedia-org-4107	28	114	References	reference	NNS
en-wikipedia-org-4107	28	115	12	12	CD
en-wikipedia-org-4107	28	116	External	external	JJ
en-wikipedia-org-4107	28	117	links	link	NNS
en-wikipedia-org-4107	28	118	Uses	use	VBZ
en-wikipedia-org-4107	28	119	Medical	Medical	NNP
en-wikipedia-org-4107	28	120	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	28	121	is	be	VBZ
en-wikipedia-org-4107	28	122	used	use	VBN
en-wikipedia-org-4107	28	123	to	to	TO
en-wikipedia-org-4107	28	124	treat	treat	VB
en-wikipedia-org-4107	28	125	attention	attention	NN
en-wikipedia-org-4107	28	126	deficit	deficit	NN
en-wikipedia-org-4107	28	127	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	28	128	disorder	disorder	NN
en-wikipedia-org-4107	28	129	(	(	-LRB-
en-wikipedia-org-4107	28	130	ADHD	ADHD	NNP
en-wikipedia-org-4107	28	131	)	)	-RRB-
en-wikipedia-org-4107	28	132	,	,	,
en-wikipedia-org-4107	28	133	narcolepsy	narcolepsy	NN
en-wikipedia-org-4107	28	134	(	(	-LRB-
en-wikipedia-org-4107	28	135	a	a	DT
en-wikipedia-org-4107	28	136	sleep	sleep	NN
en-wikipedia-org-4107	28	137	disorder	disorder	NN
en-wikipedia-org-4107	28	138	)	)	-RRB-
en-wikipedia-org-4107	28	139	,	,	,
en-wikipedia-org-4107	28	140	and	and	CC
en-wikipedia-org-4107	28	141	obesity	obesity	NN
en-wikipedia-org-4107	28	142	,	,	,
en-wikipedia-org-4107	28	143	and	and	CC
en-wikipedia-org-4107	28	144	is	be	VBZ
en-wikipedia-org-4107	28	145	sometimes	sometimes	RB
en-wikipedia-org-4107	28	146	prescribed	prescribe	VBN
en-wikipedia-org-4107	28	147	off	off	NN
en-wikipedia-org-4107	28	148	-	-	HYPH
en-wikipedia-org-4107	28	149	label	label	NNP
en-wikipedia-org-4107	28	150	for	for	IN
en-wikipedia-org-4107	28	151	its	-PRON-	PRP$
en-wikipedia-org-4107	28	152	past	past	JJ
en-wikipedia-org-4107	28	153	medical	medical	JJ
en-wikipedia-org-4107	28	154	indications	indication	NNS
en-wikipedia-org-4107	28	155	,	,	,
en-wikipedia-org-4107	28	156	particularly	particularly	RB
en-wikipedia-org-4107	28	157	for	for	IN
en-wikipedia-org-4107	28	158	depression	depression	NN
en-wikipedia-org-4107	28	159	and	and	CC
en-wikipedia-org-4107	28	160	chronic	chronic	JJ
en-wikipedia-org-4107	28	161	pain	pain	NN
en-wikipedia-org-4107	28	162	.	.	.
en-wikipedia-org-4107	29	1	[	[	-LRB-
en-wikipedia-org-4107	29	2	2][35][49	2][35][49	CD
en-wikipedia-org-4107	29	3	]	]	-RRB-
en-wikipedia-org-4107	29	4	Long	long	JJ
en-wikipedia-org-4107	29	5	-	-	HYPH
en-wikipedia-org-4107	29	6	term	term	NN
en-wikipedia-org-4107	29	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	29	8	exposure	exposure	NN
en-wikipedia-org-4107	29	9	at	at	IN
en-wikipedia-org-4107	29	10	sufficiently	sufficiently	RB
en-wikipedia-org-4107	29	11	high	high	JJ
en-wikipedia-org-4107	29	12	doses	dose	NNS
en-wikipedia-org-4107	29	13	in	in	IN
en-wikipedia-org-4107	29	14	some	some	DT
en-wikipedia-org-4107	29	15	animal	animal	NN
en-wikipedia-org-4107	29	16	species	specie	NNS
en-wikipedia-org-4107	29	17	is	be	VBZ
en-wikipedia-org-4107	29	18	known	know	VBN
en-wikipedia-org-4107	29	19	to	to	TO
en-wikipedia-org-4107	29	20	produce	produce	VB
en-wikipedia-org-4107	29	21	abnormal	abnormal	JJ
en-wikipedia-org-4107	29	22	dopamine	dopamine	NN
en-wikipedia-org-4107	29	23	system	system	NN
en-wikipedia-org-4107	29	24	development	development	NN
en-wikipedia-org-4107	29	25	or	or	CC
en-wikipedia-org-4107	29	26	nerve	nerve	NN
en-wikipedia-org-4107	29	27	damage,[50][51	damage,[50][51	NNS
en-wikipedia-org-4107	29	28	]	]	-RRB-
en-wikipedia-org-4107	29	29	but	but	CC
en-wikipedia-org-4107	29	30	,	,	,
en-wikipedia-org-4107	29	31	in	in	IN
en-wikipedia-org-4107	29	32	humans	human	NNS
en-wikipedia-org-4107	29	33	with	with	IN
en-wikipedia-org-4107	29	34	ADHD	ADHD	NNP
en-wikipedia-org-4107	29	35	,	,	,
en-wikipedia-org-4107	29	36	pharmaceutical	pharmaceutical	JJ
en-wikipedia-org-4107	29	37	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	29	38	,	,	,
en-wikipedia-org-4107	29	39	at	at	IN
en-wikipedia-org-4107	29	40	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	29	41	dosages	dosage	NNS
en-wikipedia-org-4107	29	42	,	,	,
en-wikipedia-org-4107	29	43	appear	appear	VB
en-wikipedia-org-4107	29	44	to	to	TO
en-wikipedia-org-4107	29	45	improve	improve	VB
en-wikipedia-org-4107	29	46	brain	brain	NN
en-wikipedia-org-4107	29	47	development	development	NN
en-wikipedia-org-4107	29	48	and	and	CC
en-wikipedia-org-4107	29	49	nerve	nerve	NN
en-wikipedia-org-4107	29	50	growth	growth	NN
en-wikipedia-org-4107	29	51	.	.	.
en-wikipedia-org-4107	30	1	[	[	-LRB-
en-wikipedia-org-4107	30	2	52][53][54	52][53][54	CD
en-wikipedia-org-4107	30	3	]	]	-RRB-
en-wikipedia-org-4107	30	4	Reviews	review	NNS
en-wikipedia-org-4107	30	5	of	of	IN
en-wikipedia-org-4107	30	6	magnetic	magnetic	JJ
en-wikipedia-org-4107	30	7	resonance	resonance	NN
en-wikipedia-org-4107	30	8	imaging	imaging	NN
en-wikipedia-org-4107	30	9	(	(	-LRB-
en-wikipedia-org-4107	30	10	MRI	MRI	NNP
en-wikipedia-org-4107	30	11	)	)	-RRB-
en-wikipedia-org-4107	30	12	studies	study	NNS
en-wikipedia-org-4107	30	13	suggest	suggest	VBP
en-wikipedia-org-4107	30	14	that	that	IN
en-wikipedia-org-4107	30	15	long	long	JJ
en-wikipedia-org-4107	30	16	-	-	HYPH
en-wikipedia-org-4107	30	17	term	term	NN
en-wikipedia-org-4107	30	18	treatment	treatment	NN
en-wikipedia-org-4107	30	19	with	with	IN
en-wikipedia-org-4107	30	20	amphetamine	amphetamine	NN
en-wikipedia-org-4107	30	21	decreases	decrease	VBZ
en-wikipedia-org-4107	30	22	abnormalities	abnormality	NNS
en-wikipedia-org-4107	30	23	in	in	IN
en-wikipedia-org-4107	30	24	brain	brain	NN
en-wikipedia-org-4107	30	25	structure	structure	NN
en-wikipedia-org-4107	30	26	and	and	CC
en-wikipedia-org-4107	30	27	function	function	NN
en-wikipedia-org-4107	30	28	found	find	VBN
en-wikipedia-org-4107	30	29	in	in	IN
en-wikipedia-org-4107	30	30	subjects	subject	NNS
en-wikipedia-org-4107	30	31	with	with	IN
en-wikipedia-org-4107	30	32	ADHD	ADHD	NNP
en-wikipedia-org-4107	30	33	,	,	,
en-wikipedia-org-4107	30	34	and	and	CC
en-wikipedia-org-4107	30	35	improves	improve	VBZ
en-wikipedia-org-4107	30	36	function	function	NN
en-wikipedia-org-4107	30	37	in	in	IN
en-wikipedia-org-4107	30	38	several	several	JJ
en-wikipedia-org-4107	30	39	parts	part	NNS
en-wikipedia-org-4107	30	40	of	of	IN
en-wikipedia-org-4107	30	41	the	the	DT
en-wikipedia-org-4107	30	42	brain	brain	NN
en-wikipedia-org-4107	30	43	,	,	,
en-wikipedia-org-4107	30	44	such	such	JJ
en-wikipedia-org-4107	30	45	as	as	IN
en-wikipedia-org-4107	30	46	the	the	DT
en-wikipedia-org-4107	30	47	right	right	JJ
en-wikipedia-org-4107	30	48	caudate	caudate	JJ
en-wikipedia-org-4107	30	49	nucleus	nucleus	NN
en-wikipedia-org-4107	30	50	of	of	IN
en-wikipedia-org-4107	30	51	the	the	DT
en-wikipedia-org-4107	30	52	basal	basal	NNP
en-wikipedia-org-4107	30	53	ganglia	ganglia	NNP
en-wikipedia-org-4107	30	54	.	.	.
en-wikipedia-org-4107	31	1	[	[	-LRB-
en-wikipedia-org-4107	31	2	52][53][54	52][53][54	CD
en-wikipedia-org-4107	31	3	]	]	-RRB-
en-wikipedia-org-4107	31	4	Reviews	Reviews	NNP
en-wikipedia-org-4107	31	5	of	of	IN
en-wikipedia-org-4107	31	6	clinical	clinical	JJ
en-wikipedia-org-4107	31	7	stimulant	stimulant	NN
en-wikipedia-org-4107	31	8	research	research	NN
en-wikipedia-org-4107	31	9	have	have	VBP
en-wikipedia-org-4107	31	10	established	establish	VBN
en-wikipedia-org-4107	31	11	the	the	DT
en-wikipedia-org-4107	31	12	safety	safety	NN
en-wikipedia-org-4107	31	13	and	and	CC
en-wikipedia-org-4107	31	14	effectiveness	effectiveness	NN
en-wikipedia-org-4107	31	15	of	of	IN
en-wikipedia-org-4107	31	16	long	long	JJ
en-wikipedia-org-4107	31	17	-	-	HYPH
en-wikipedia-org-4107	31	18	term	term	NN
en-wikipedia-org-4107	31	19	continuous	continuous	JJ
en-wikipedia-org-4107	31	20	amphetamine	amphetamine	NN
en-wikipedia-org-4107	31	21	use	use	NN
en-wikipedia-org-4107	31	22	for	for	IN
en-wikipedia-org-4107	31	23	the	the	DT
en-wikipedia-org-4107	31	24	treatment	treatment	NN
en-wikipedia-org-4107	31	25	of	of	IN
en-wikipedia-org-4107	31	26	ADHD	ADHD	NNP
en-wikipedia-org-4107	31	27	.	.	.
en-wikipedia-org-4107	32	1	[	[	-LRB-
en-wikipedia-org-4107	32	2	43][55][56	43][55][56	CD
en-wikipedia-org-4107	32	3	]	]	-RRB-
en-wikipedia-org-4107	32	4	Randomized	randomize	VBN
en-wikipedia-org-4107	32	5	controlled	controlled	JJ
en-wikipedia-org-4107	32	6	trials	trial	NNS
en-wikipedia-org-4107	32	7	of	of	IN
en-wikipedia-org-4107	32	8	continuous	continuous	JJ
en-wikipedia-org-4107	32	9	stimulant	stimulant	NN
en-wikipedia-org-4107	32	10	therapy	therapy	NN
en-wikipedia-org-4107	32	11	for	for	IN
en-wikipedia-org-4107	32	12	the	the	DT
en-wikipedia-org-4107	32	13	treatment	treatment	NN
en-wikipedia-org-4107	32	14	of	of	IN
en-wikipedia-org-4107	32	15	ADHD	ADHD	NNP
en-wikipedia-org-4107	32	16	spanning	span	VBG
en-wikipedia-org-4107	32	17	2	2	CD
en-wikipedia-org-4107	32	18	 	  	_SP
en-wikipedia-org-4107	32	19	years	year	NNS
en-wikipedia-org-4107	32	20	have	have	VBP
en-wikipedia-org-4107	32	21	demonstrated	demonstrate	VBN
en-wikipedia-org-4107	32	22	treatment	treatment	NN
en-wikipedia-org-4107	32	23	effectiveness	effectiveness	NN
en-wikipedia-org-4107	32	24	and	and	CC
en-wikipedia-org-4107	32	25	safety	safety	NN
en-wikipedia-org-4107	32	26	.	.	.
en-wikipedia-org-4107	33	1	[	[	-LRB-
en-wikipedia-org-4107	33	2	43][55	43][55	LS
en-wikipedia-org-4107	33	3	]	]	-RRB-
en-wikipedia-org-4107	33	4	Two	two	CD
en-wikipedia-org-4107	33	5	reviews	review	NNS
en-wikipedia-org-4107	33	6	have	have	VBP
en-wikipedia-org-4107	33	7	indicated	indicate	VBN
en-wikipedia-org-4107	33	8	that	that	IN
en-wikipedia-org-4107	33	9	long	long	JJ
en-wikipedia-org-4107	33	10	-	-	HYPH
en-wikipedia-org-4107	33	11	term	term	NN
en-wikipedia-org-4107	33	12	continuous	continuous	JJ
en-wikipedia-org-4107	33	13	stimulant	stimulant	NN
en-wikipedia-org-4107	33	14	therapy	therapy	NN
en-wikipedia-org-4107	33	15	for	for	IN
en-wikipedia-org-4107	33	16	ADHD	ADHD	NNP
en-wikipedia-org-4107	33	17	is	be	VBZ
en-wikipedia-org-4107	33	18	effective	effective	JJ
en-wikipedia-org-4107	33	19	for	for	IN
en-wikipedia-org-4107	33	20	reducing	reduce	VBG
en-wikipedia-org-4107	33	21	the	the	DT
en-wikipedia-org-4107	33	22	core	core	NN
en-wikipedia-org-4107	33	23	symptoms	symptom	NNS
en-wikipedia-org-4107	33	24	of	of	IN
en-wikipedia-org-4107	33	25	ADHD	ADHD	NNP
en-wikipedia-org-4107	33	26	(	(	-LRB-
en-wikipedia-org-4107	33	27	i.e.	i.e.	FW
en-wikipedia-org-4107	33	28	,	,	,
en-wikipedia-org-4107	33	29	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	33	30	,	,	,
en-wikipedia-org-4107	33	31	inattention	inattention	NN
en-wikipedia-org-4107	33	32	,	,	,
en-wikipedia-org-4107	33	33	and	and	CC
en-wikipedia-org-4107	33	34	impulsivity	impulsivity	NN
en-wikipedia-org-4107	33	35	)	)	-RRB-
en-wikipedia-org-4107	33	36	,	,	,
en-wikipedia-org-4107	33	37	enhancing	enhance	VBG
en-wikipedia-org-4107	33	38	quality	quality	NN
en-wikipedia-org-4107	33	39	of	of	IN
en-wikipedia-org-4107	33	40	life	life	NN
en-wikipedia-org-4107	33	41	and	and	CC
en-wikipedia-org-4107	33	42	academic	academic	JJ
en-wikipedia-org-4107	33	43	achievement	achievement	NN
en-wikipedia-org-4107	33	44	,	,	,
en-wikipedia-org-4107	33	45	and	and	CC
en-wikipedia-org-4107	33	46	producing	produce	VBG
en-wikipedia-org-4107	33	47	improvements	improvement	NNS
en-wikipedia-org-4107	33	48	in	in	IN
en-wikipedia-org-4107	33	49	a	a	DT
en-wikipedia-org-4107	33	50	large	large	JJ
en-wikipedia-org-4107	33	51	number	number	NN
en-wikipedia-org-4107	33	52	of	of	IN
en-wikipedia-org-4107	33	53	functional	functional	JJ
en-wikipedia-org-4107	33	54	outcomes[note	outcomes[note	CD
en-wikipedia-org-4107	33	55	6	6	CD
en-wikipedia-org-4107	33	56	]	]	-RRB-
en-wikipedia-org-4107	33	57	across	across	IN
en-wikipedia-org-4107	33	58	9	9	CD
en-wikipedia-org-4107	33	59	 	  	_SP
en-wikipedia-org-4107	33	60	categories	category	NNS
en-wikipedia-org-4107	33	61	of	of	IN
en-wikipedia-org-4107	33	62	outcomes	outcome	NNS
en-wikipedia-org-4107	33	63	related	relate	VBN
en-wikipedia-org-4107	33	64	to	to	IN
en-wikipedia-org-4107	33	65	academics	academic	NNS
en-wikipedia-org-4107	33	66	,	,	,
en-wikipedia-org-4107	33	67	antisocial	antisocial	JJ
en-wikipedia-org-4107	33	68	behavior	behavior	NN
en-wikipedia-org-4107	33	69	,	,	,
en-wikipedia-org-4107	33	70	driving	driving	NN
en-wikipedia-org-4107	33	71	,	,	,
en-wikipedia-org-4107	33	72	non	non	JJ
en-wikipedia-org-4107	33	73	-	-	JJ
en-wikipedia-org-4107	33	74	medicinal	medicinal	JJ
en-wikipedia-org-4107	33	75	drug	drug	NN
en-wikipedia-org-4107	33	76	use	use	NN
en-wikipedia-org-4107	33	77	,	,	,
en-wikipedia-org-4107	33	78	obesity	obesity	NN
en-wikipedia-org-4107	33	79	,	,	,
en-wikipedia-org-4107	33	80	occupation	occupation	NN
en-wikipedia-org-4107	33	81	,	,	,
en-wikipedia-org-4107	33	82	self	self	NN
en-wikipedia-org-4107	33	83	-	-	HYPH
en-wikipedia-org-4107	33	84	esteem	esteem	NN
en-wikipedia-org-4107	33	85	,	,	,
en-wikipedia-org-4107	33	86	service	service	NN
en-wikipedia-org-4107	33	87	use	use	NN
en-wikipedia-org-4107	33	88	(	(	-LRB-
en-wikipedia-org-4107	33	89	i.e.	i.e.	FW
en-wikipedia-org-4107	33	90	,	,	,
en-wikipedia-org-4107	33	91	academic	academic	JJ
en-wikipedia-org-4107	33	92	,	,	,
en-wikipedia-org-4107	33	93	occupational	occupational	JJ
en-wikipedia-org-4107	33	94	,	,	,
en-wikipedia-org-4107	33	95	health	health	NN
en-wikipedia-org-4107	33	96	,	,	,
en-wikipedia-org-4107	33	97	financial	financial	JJ
en-wikipedia-org-4107	33	98	,	,	,
en-wikipedia-org-4107	33	99	and	and	CC
en-wikipedia-org-4107	33	100	legal	legal	JJ
en-wikipedia-org-4107	33	101	services	service	NNS
en-wikipedia-org-4107	33	102	)	)	-RRB-
en-wikipedia-org-4107	33	103	,	,	,
en-wikipedia-org-4107	33	104	and	and	CC
en-wikipedia-org-4107	33	105	social	social	JJ
en-wikipedia-org-4107	33	106	function	function	NN
en-wikipedia-org-4107	33	107	.	.	.
en-wikipedia-org-4107	34	1	[	[	-LRB-
en-wikipedia-org-4107	34	2	43][56	43][56	CD
en-wikipedia-org-4107	34	3	]	]	-RRB-
en-wikipedia-org-4107	34	4	One	one	CD
en-wikipedia-org-4107	34	5	review	review	NN
en-wikipedia-org-4107	34	6	highlighted	highlight	VBD
en-wikipedia-org-4107	34	7	a	a	DT
en-wikipedia-org-4107	34	8	nine	nine	CD
en-wikipedia-org-4107	34	9	-	-	HYPH
en-wikipedia-org-4107	34	10	month	month	NN
en-wikipedia-org-4107	34	11	randomized	randomize	VBN
en-wikipedia-org-4107	34	12	controlled	controlled	JJ
en-wikipedia-org-4107	34	13	trial	trial	NN
en-wikipedia-org-4107	34	14	of	of	IN
en-wikipedia-org-4107	34	15	amphetamine	amphetamine	NN
en-wikipedia-org-4107	34	16	treatment	treatment	NN
en-wikipedia-org-4107	34	17	for	for	IN
en-wikipedia-org-4107	34	18	ADHD	ADHD	NNP
en-wikipedia-org-4107	34	19	in	in	IN
en-wikipedia-org-4107	34	20	children	child	NNS
en-wikipedia-org-4107	34	21	that	that	WDT
en-wikipedia-org-4107	34	22	found	find	VBD
en-wikipedia-org-4107	34	23	an	an	DT
en-wikipedia-org-4107	34	24	average	average	JJ
en-wikipedia-org-4107	34	25	increase	increase	NN
en-wikipedia-org-4107	34	26	of	of	IN
en-wikipedia-org-4107	34	27	4.5	4.5	CD
en-wikipedia-org-4107	34	28	 	  	_SP
en-wikipedia-org-4107	34	29	IQ	IQ	NNP
en-wikipedia-org-4107	34	30	points	point	NNS
en-wikipedia-org-4107	34	31	,	,	,
en-wikipedia-org-4107	34	32	continued	continue	VBD
en-wikipedia-org-4107	34	33	increases	increase	NNS
en-wikipedia-org-4107	34	34	in	in	IN
en-wikipedia-org-4107	34	35	attention	attention	NN
en-wikipedia-org-4107	34	36	,	,	,
en-wikipedia-org-4107	34	37	and	and	CC
en-wikipedia-org-4107	34	38	continued	continue	VBN
en-wikipedia-org-4107	34	39	decreases	decrease	NNS
en-wikipedia-org-4107	34	40	in	in	IN
en-wikipedia-org-4107	34	41	disruptive	disruptive	JJ
en-wikipedia-org-4107	34	42	behaviors	behavior	NNS
en-wikipedia-org-4107	34	43	and	and	CC
en-wikipedia-org-4107	34	44	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	34	45	.	.	.
en-wikipedia-org-4107	35	1	[	[	-LRB-
en-wikipedia-org-4107	35	2	55	55	CD
en-wikipedia-org-4107	35	3	]	]	-RRB-
en-wikipedia-org-4107	35	4	Another	another	DT
en-wikipedia-org-4107	35	5	review	review	NN
en-wikipedia-org-4107	35	6	indicated	indicate	VBD
en-wikipedia-org-4107	35	7	that	that	IN
en-wikipedia-org-4107	35	8	,	,	,
en-wikipedia-org-4107	35	9	based	base	VBN
en-wikipedia-org-4107	35	10	upon	upon	IN
en-wikipedia-org-4107	35	11	the	the	DT
en-wikipedia-org-4107	35	12	longest	long	JJS
en-wikipedia-org-4107	35	13	follow	follow	NN
en-wikipedia-org-4107	35	14	-	-	HYPH
en-wikipedia-org-4107	35	15	up	up	RP
en-wikipedia-org-4107	35	16	studies	study	NNS
en-wikipedia-org-4107	35	17	conducted	conduct	VBN
en-wikipedia-org-4107	35	18	to	to	IN
en-wikipedia-org-4107	35	19	date	date	NN
en-wikipedia-org-4107	35	20	,	,	,
en-wikipedia-org-4107	35	21	lifetime	lifetime	NN
en-wikipedia-org-4107	35	22	stimulant	stimulant	NN
en-wikipedia-org-4107	35	23	therapy	therapy	NN
en-wikipedia-org-4107	35	24	that	that	WDT
en-wikipedia-org-4107	35	25	begins	begin	VBZ
en-wikipedia-org-4107	35	26	during	during	IN
en-wikipedia-org-4107	35	27	childhood	childhood	NN
en-wikipedia-org-4107	35	28	is	be	VBZ
en-wikipedia-org-4107	35	29	continuously	continuously	RB
en-wikipedia-org-4107	35	30	effective	effective	JJ
en-wikipedia-org-4107	35	31	for	for	IN
en-wikipedia-org-4107	35	32	controlling	control	VBG
en-wikipedia-org-4107	35	33	ADHD	ADHD	NNP
en-wikipedia-org-4107	35	34	symptoms	symptom	NNS
en-wikipedia-org-4107	35	35	and	and	CC
en-wikipedia-org-4107	35	36	reduces	reduce	VBZ
en-wikipedia-org-4107	35	37	the	the	DT
en-wikipedia-org-4107	35	38	risk	risk	NN
en-wikipedia-org-4107	35	39	of	of	IN
en-wikipedia-org-4107	35	40	developing	develop	VBG
en-wikipedia-org-4107	35	41	a	a	DT
en-wikipedia-org-4107	35	42	substance	substance	NN
en-wikipedia-org-4107	35	43	use	use	NN
en-wikipedia-org-4107	35	44	disorder	disorder	NN
en-wikipedia-org-4107	35	45	as	as	IN
en-wikipedia-org-4107	35	46	an	an	DT
en-wikipedia-org-4107	35	47	adult	adult	NN
en-wikipedia-org-4107	35	48	.	.	.
en-wikipedia-org-4107	36	1	[	[	-LRB-
en-wikipedia-org-4107	36	2	43	43	CD
en-wikipedia-org-4107	36	3	]	]	-RRB-
en-wikipedia-org-4107	36	4	Current	current	JJ
en-wikipedia-org-4107	36	5	models	model	NNS
en-wikipedia-org-4107	36	6	of	of	IN
en-wikipedia-org-4107	36	7	ADHD	ADHD	NNP
en-wikipedia-org-4107	36	8	suggest	suggest	VBP
en-wikipedia-org-4107	36	9	that	that	IN
en-wikipedia-org-4107	36	10	it	-PRON-	PRP
en-wikipedia-org-4107	36	11	is	be	VBZ
en-wikipedia-org-4107	36	12	associated	associate	VBN
en-wikipedia-org-4107	36	13	with	with	IN
en-wikipedia-org-4107	36	14	functional	functional	JJ
en-wikipedia-org-4107	36	15	impairments	impairment	NNS
en-wikipedia-org-4107	36	16	in	in	IN
en-wikipedia-org-4107	36	17	some	some	DT
en-wikipedia-org-4107	36	18	of	of	IN
en-wikipedia-org-4107	36	19	the	the	DT
en-wikipedia-org-4107	36	20	brain	brain	NN
en-wikipedia-org-4107	36	21	's	's	POS
en-wikipedia-org-4107	36	22	neurotransmitter	neurotransmitter	NN
en-wikipedia-org-4107	36	23	systems;[57	systems;[57	NNP
en-wikipedia-org-4107	36	24	]	]	-RRB-
en-wikipedia-org-4107	36	25	these	these	DT
en-wikipedia-org-4107	36	26	functional	functional	JJ
en-wikipedia-org-4107	36	27	impairments	impairment	NNS
en-wikipedia-org-4107	36	28	involve	involve	VBP
en-wikipedia-org-4107	36	29	impaired	impair	VBN
en-wikipedia-org-4107	36	30	dopamine	dopamine	NN
en-wikipedia-org-4107	36	31	neurotransmission	neurotransmission	NN
en-wikipedia-org-4107	36	32	in	in	IN
en-wikipedia-org-4107	36	33	the	the	DT
en-wikipedia-org-4107	36	34	mesocorticolimbic	mesocorticolimbic	JJ
en-wikipedia-org-4107	36	35	projection	projection	NN
en-wikipedia-org-4107	36	36	and	and	CC
en-wikipedia-org-4107	36	37	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	36	38	neurotransmission	neurotransmission	NN
en-wikipedia-org-4107	36	39	in	in	IN
en-wikipedia-org-4107	36	40	the	the	DT
en-wikipedia-org-4107	36	41	noradrenergic	noradrenergic	JJ
en-wikipedia-org-4107	36	42	projections	projection	NNS
en-wikipedia-org-4107	36	43	from	from	IN
en-wikipedia-org-4107	36	44	the	the	DT
en-wikipedia-org-4107	36	45	locus	locus	NN
en-wikipedia-org-4107	36	46	coeruleus	coeruleus	JJ
en-wikipedia-org-4107	36	47	to	to	IN
en-wikipedia-org-4107	36	48	the	the	DT
en-wikipedia-org-4107	36	49	prefrontal	prefrontal	JJ
en-wikipedia-org-4107	36	50	cortex	cortex	NNP
en-wikipedia-org-4107	36	51	.	.	.
en-wikipedia-org-4107	37	1	[	[	-LRB-
en-wikipedia-org-4107	37	2	57	57	CD
en-wikipedia-org-4107	37	3	]	]	-RRB-
en-wikipedia-org-4107	37	4	Psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	37	5	like	like	IN
en-wikipedia-org-4107	37	6	methylphenidate	methylphenidate	NN
en-wikipedia-org-4107	37	7	and	and	CC
en-wikipedia-org-4107	37	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	37	9	are	be	VBP
en-wikipedia-org-4107	37	10	effective	effective	JJ
en-wikipedia-org-4107	37	11	in	in	IN
en-wikipedia-org-4107	37	12	treating	treat	VBG
en-wikipedia-org-4107	37	13	ADHD	ADHD	NNP
en-wikipedia-org-4107	37	14	because	because	IN
en-wikipedia-org-4107	37	15	they	-PRON-	PRP
en-wikipedia-org-4107	37	16	increase	increase	VBP
en-wikipedia-org-4107	37	17	neurotransmitter	neurotransmitter	NN
en-wikipedia-org-4107	37	18	activity	activity	NN
en-wikipedia-org-4107	37	19	in	in	IN
en-wikipedia-org-4107	37	20	these	these	DT
en-wikipedia-org-4107	37	21	systems	system	NNS
en-wikipedia-org-4107	37	22	.	.	.
en-wikipedia-org-4107	38	1	[	[	-LRB-
en-wikipedia-org-4107	38	2	26][57][58	26][57][58	CD
en-wikipedia-org-4107	38	3	]	]	-RRB-
en-wikipedia-org-4107	38	4	Approximately	approximately	RB
en-wikipedia-org-4107	38	5	80	80	CD
en-wikipedia-org-4107	38	6	%	%	NN
en-wikipedia-org-4107	38	7	of	of	IN
en-wikipedia-org-4107	38	8	those	those	DT
en-wikipedia-org-4107	38	9	who	who	WP
en-wikipedia-org-4107	38	10	use	use	VBP
en-wikipedia-org-4107	38	11	these	these	DT
en-wikipedia-org-4107	38	12	stimulants	stimulant	NNS
en-wikipedia-org-4107	38	13	see	see	VBP
en-wikipedia-org-4107	38	14	improvements	improvement	NNS
en-wikipedia-org-4107	38	15	in	in	IN
en-wikipedia-org-4107	38	16	ADHD	ADHD	NNP
en-wikipedia-org-4107	38	17	symptoms	symptom	NNS
en-wikipedia-org-4107	38	18	.	.	.
en-wikipedia-org-4107	39	1	[	[	-LRB-
en-wikipedia-org-4107	39	2	59	59	CD
en-wikipedia-org-4107	39	3	]	]	-RRB-
en-wikipedia-org-4107	39	4	Children	child	NNS
en-wikipedia-org-4107	39	5	with	with	IN
en-wikipedia-org-4107	39	6	ADHD	ADHD	NNP
en-wikipedia-org-4107	39	7	who	who	WP
en-wikipedia-org-4107	39	8	use	use	VBP
en-wikipedia-org-4107	39	9	stimulant	stimulant	NN
en-wikipedia-org-4107	39	10	medications	medication	NNS
en-wikipedia-org-4107	39	11	generally	generally	RB
en-wikipedia-org-4107	39	12	have	have	VBP
en-wikipedia-org-4107	39	13	better	well	JJR
en-wikipedia-org-4107	39	14	relationships	relationship	NNS
en-wikipedia-org-4107	39	15	with	with	IN
en-wikipedia-org-4107	39	16	peers	peer	NNS
en-wikipedia-org-4107	39	17	and	and	CC
en-wikipedia-org-4107	39	18	family	family	NN
en-wikipedia-org-4107	39	19	members	member	NNS
en-wikipedia-org-4107	39	20	,	,	,
en-wikipedia-org-4107	39	21	perform	perform	VBP
en-wikipedia-org-4107	39	22	better	well	RBR
en-wikipedia-org-4107	39	23	in	in	IN
en-wikipedia-org-4107	39	24	school	school	NN
en-wikipedia-org-4107	39	25	,	,	,
en-wikipedia-org-4107	39	26	are	be	VBP
en-wikipedia-org-4107	39	27	less	less	RBR
en-wikipedia-org-4107	39	28	distractible	distractible	JJ
en-wikipedia-org-4107	39	29	and	and	CC
en-wikipedia-org-4107	39	30	impulsive	impulsive	JJ
en-wikipedia-org-4107	39	31	,	,	,
en-wikipedia-org-4107	39	32	and	and	CC
en-wikipedia-org-4107	39	33	have	have	VBP
en-wikipedia-org-4107	39	34	longer	long	JJR
en-wikipedia-org-4107	39	35	attention	attention	NN
en-wikipedia-org-4107	39	36	spans	span	NNS
en-wikipedia-org-4107	39	37	.	.	.
en-wikipedia-org-4107	40	1	[	[	-LRB-
en-wikipedia-org-4107	40	2	60][61	60][61	CD
en-wikipedia-org-4107	40	3	]	]	-RRB-
en-wikipedia-org-4107	40	4	The	the	DT
en-wikipedia-org-4107	40	5	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	40	6	reviews[note	reviews[note	NNP
en-wikipedia-org-4107	40	7	7	7	CD
en-wikipedia-org-4107	40	8	]	]	-RRB-
en-wikipedia-org-4107	40	9	on	on	IN
en-wikipedia-org-4107	40	10	the	the	DT
en-wikipedia-org-4107	40	11	treatment	treatment	NN
en-wikipedia-org-4107	40	12	of	of	IN
en-wikipedia-org-4107	40	13	ADHD	ADHD	NNP
en-wikipedia-org-4107	40	14	in	in	IN
en-wikipedia-org-4107	40	15	children	child	NNS
en-wikipedia-org-4107	40	16	,	,	,
en-wikipedia-org-4107	40	17	adolescents	adolescent	NNS
en-wikipedia-org-4107	40	18	,	,	,
en-wikipedia-org-4107	40	19	and	and	CC
en-wikipedia-org-4107	40	20	adults	adult	NNS
en-wikipedia-org-4107	40	21	with	with	IN
en-wikipedia-org-4107	40	22	pharmaceutical	pharmaceutical	JJ
en-wikipedia-org-4107	40	23	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	40	24	stated	state	VBD
en-wikipedia-org-4107	40	25	that	that	IN
en-wikipedia-org-4107	40	26	short	short	JJ
en-wikipedia-org-4107	40	27	-	-	HYPH
en-wikipedia-org-4107	40	28	term	term	NN
en-wikipedia-org-4107	40	29	studies	study	NNS
en-wikipedia-org-4107	40	30	have	have	VBP
en-wikipedia-org-4107	40	31	demonstrated	demonstrate	VBN
en-wikipedia-org-4107	40	32	that	that	IN
en-wikipedia-org-4107	40	33	these	these	DT
en-wikipedia-org-4107	40	34	drugs	drug	NNS
en-wikipedia-org-4107	40	35	decrease	decrease	VBP
en-wikipedia-org-4107	40	36	the	the	DT
en-wikipedia-org-4107	40	37	severity	severity	NN
en-wikipedia-org-4107	40	38	of	of	IN
en-wikipedia-org-4107	40	39	symptoms	symptom	NNS
en-wikipedia-org-4107	40	40	,	,	,
en-wikipedia-org-4107	40	41	but	but	CC
en-wikipedia-org-4107	40	42	they	-PRON-	PRP
en-wikipedia-org-4107	40	43	have	have	VBP
en-wikipedia-org-4107	40	44	higher	high	JJR
en-wikipedia-org-4107	40	45	discontinuation	discontinuation	NN
en-wikipedia-org-4107	40	46	rates	rate	NNS
en-wikipedia-org-4107	40	47	than	than	IN
en-wikipedia-org-4107	40	48	non	non	JJ
en-wikipedia-org-4107	40	49	-	-	JJ
en-wikipedia-org-4107	40	50	stimulant	stimulant	JJ
en-wikipedia-org-4107	40	51	medications	medication	NNS
en-wikipedia-org-4107	40	52	due	due	JJ
en-wikipedia-org-4107	40	53	to	to	IN
en-wikipedia-org-4107	40	54	their	-PRON-	PRP$
en-wikipedia-org-4107	40	55	adverse	adverse	JJ
en-wikipedia-org-4107	40	56	side	side	NN
en-wikipedia-org-4107	40	57	effects	effect	NNS
en-wikipedia-org-4107	40	58	.	.	.
en-wikipedia-org-4107	41	1	[	[	-LRB-
en-wikipedia-org-4107	41	2	63][64	63][64	CD
en-wikipedia-org-4107	41	3	]	]	-RRB-
en-wikipedia-org-4107	41	4	A	a	DT
en-wikipedia-org-4107	41	5	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	41	6	review	review	NN
en-wikipedia-org-4107	41	7	on	on	IN
en-wikipedia-org-4107	41	8	the	the	DT
en-wikipedia-org-4107	41	9	treatment	treatment	NN
en-wikipedia-org-4107	41	10	of	of	IN
en-wikipedia-org-4107	41	11	ADHD	ADHD	NNP
en-wikipedia-org-4107	41	12	in	in	IN
en-wikipedia-org-4107	41	13	children	child	NNS
en-wikipedia-org-4107	41	14	with	with	IN
en-wikipedia-org-4107	41	15	tic	tic	JJ
en-wikipedia-org-4107	41	16	disorders	disorder	NNS
en-wikipedia-org-4107	41	17	such	such	JJ
en-wikipedia-org-4107	41	18	as	as	IN
en-wikipedia-org-4107	41	19	Tourette	Tourette	NNP
en-wikipedia-org-4107	41	20	syndrome	syndrome	NN
en-wikipedia-org-4107	41	21	indicated	indicate	VBD
en-wikipedia-org-4107	41	22	that	that	IN
en-wikipedia-org-4107	41	23	stimulants	stimulant	NNS
en-wikipedia-org-4107	41	24	in	in	IN
en-wikipedia-org-4107	41	25	general	general	JJ
en-wikipedia-org-4107	41	26	do	do	VBP
en-wikipedia-org-4107	41	27	not	not	RB
en-wikipedia-org-4107	41	28	make	make	VB
en-wikipedia-org-4107	41	29	tics	tic	NNS
en-wikipedia-org-4107	41	30	worse	bad	JJR
en-wikipedia-org-4107	41	31	,	,	,
en-wikipedia-org-4107	41	32	but	but	CC
en-wikipedia-org-4107	41	33	high	high	JJ
en-wikipedia-org-4107	41	34	doses	dose	NNS
en-wikipedia-org-4107	41	35	of	of	IN
en-wikipedia-org-4107	41	36	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	41	37	could	could	MD
en-wikipedia-org-4107	41	38	exacerbate	exacerbate	VB
en-wikipedia-org-4107	41	39	tics	tic	NNS
en-wikipedia-org-4107	41	40	in	in	IN
en-wikipedia-org-4107	41	41	some	some	DT
en-wikipedia-org-4107	41	42	individuals	individual	NNS
en-wikipedia-org-4107	41	43	.	.	.
en-wikipedia-org-4107	42	1	[	[	-LRB-
en-wikipedia-org-4107	42	2	65	65	CD
en-wikipedia-org-4107	42	3	]	]	-RRB-
en-wikipedia-org-4107	42	4	Enhancing	enhance	VBG
en-wikipedia-org-4107	42	5	performance	performance	NN
en-wikipedia-org-4107	42	6	Cognitive	Cognitive	NNP
en-wikipedia-org-4107	42	7	performance	performance	NN
en-wikipedia-org-4107	42	8	In	in	IN
en-wikipedia-org-4107	42	9	2015	2015	CD
en-wikipedia-org-4107	42	10	,	,	,
en-wikipedia-org-4107	42	11	a	a	DT
en-wikipedia-org-4107	42	12	systematic	systematic	JJ
en-wikipedia-org-4107	42	13	review	review	NN
en-wikipedia-org-4107	42	14	and	and	CC
en-wikipedia-org-4107	42	15	a	a	DT
en-wikipedia-org-4107	42	16	meta	meta	JJ
en-wikipedia-org-4107	42	17	-	-	HYPH
en-wikipedia-org-4107	42	18	analysis	analysis	NN
en-wikipedia-org-4107	42	19	of	of	IN
en-wikipedia-org-4107	42	20	high	high	JJ
en-wikipedia-org-4107	42	21	quality	quality	NN
en-wikipedia-org-4107	42	22	clinical	clinical	JJ
en-wikipedia-org-4107	42	23	trials	trial	NNS
en-wikipedia-org-4107	42	24	found	find	VBD
en-wikipedia-org-4107	42	25	that	that	IN
en-wikipedia-org-4107	42	26	,	,	,
en-wikipedia-org-4107	42	27	when	when	WRB
en-wikipedia-org-4107	42	28	used	use	VBN
en-wikipedia-org-4107	42	29	at	at	IN
en-wikipedia-org-4107	42	30	low	low	JJ
en-wikipedia-org-4107	42	31	(	(	-LRB-
en-wikipedia-org-4107	42	32	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	42	33	)	)	-RRB-
en-wikipedia-org-4107	42	34	doses	dose	NNS
en-wikipedia-org-4107	42	35	,	,	,
en-wikipedia-org-4107	42	36	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	42	37	produces	produce	VBZ
en-wikipedia-org-4107	42	38	modest	modest	JJ
en-wikipedia-org-4107	42	39	yet	yet	CC
en-wikipedia-org-4107	42	40	unambiguous	unambiguous	JJ
en-wikipedia-org-4107	42	41	improvements	improvement	NNS
en-wikipedia-org-4107	42	42	in	in	IN
en-wikipedia-org-4107	42	43	cognition	cognition	NN
en-wikipedia-org-4107	42	44	,	,	,
en-wikipedia-org-4107	42	45	including	include	VBG
en-wikipedia-org-4107	42	46	working	work	VBG
en-wikipedia-org-4107	42	47	memory	memory	NN
en-wikipedia-org-4107	42	48	,	,	,
en-wikipedia-org-4107	42	49	long	long	JJ
en-wikipedia-org-4107	42	50	-	-	HYPH
en-wikipedia-org-4107	42	51	term	term	NN
en-wikipedia-org-4107	42	52	episodic	episodic	JJ
en-wikipedia-org-4107	42	53	memory	memory	NN
en-wikipedia-org-4107	42	54	,	,	,
en-wikipedia-org-4107	42	55	inhibitory	inhibitory	JJ
en-wikipedia-org-4107	42	56	control	control	NN
en-wikipedia-org-4107	42	57	,	,	,
en-wikipedia-org-4107	42	58	and	and	CC
en-wikipedia-org-4107	42	59	some	some	DT
en-wikipedia-org-4107	42	60	aspects	aspect	NNS
en-wikipedia-org-4107	42	61	of	of	IN
en-wikipedia-org-4107	42	62	attention	attention	NN
en-wikipedia-org-4107	42	63	,	,	,
en-wikipedia-org-4107	42	64	in	in	IN
en-wikipedia-org-4107	42	65	normal	normal	JJ
en-wikipedia-org-4107	42	66	healthy	healthy	JJ
en-wikipedia-org-4107	42	67	adults;[66][67	adults;[66][67	NNS
en-wikipedia-org-4107	42	68	]	]	-RRB-
en-wikipedia-org-4107	42	69	these	these	DT
en-wikipedia-org-4107	42	70	cognition	cognition	NN
en-wikipedia-org-4107	42	71	-	-	HYPH
en-wikipedia-org-4107	42	72	enhancing	enhance	VBG
en-wikipedia-org-4107	42	73	effects	effect	NNS
en-wikipedia-org-4107	42	74	of	of	IN
en-wikipedia-org-4107	42	75	amphetamine	amphetamine	NN
en-wikipedia-org-4107	42	76	are	be	VBP
en-wikipedia-org-4107	42	77	known	know	VBN
en-wikipedia-org-4107	42	78	to	to	TO
en-wikipedia-org-4107	42	79	be	be	VB
en-wikipedia-org-4107	42	80	partially	partially	RB
en-wikipedia-org-4107	42	81	mediated	mediate	VBN
en-wikipedia-org-4107	42	82	through	through	IN
en-wikipedia-org-4107	42	83	the	the	DT
en-wikipedia-org-4107	42	84	indirect	indirect	JJ
en-wikipedia-org-4107	42	85	activation	activation	NN
en-wikipedia-org-4107	42	86	of	of	IN
en-wikipedia-org-4107	42	87	both	both	CC
en-wikipedia-org-4107	42	88	dopamine	dopamine	NN
en-wikipedia-org-4107	42	89	receptor	receptor	NN
en-wikipedia-org-4107	42	90	D1	d1	NN
en-wikipedia-org-4107	42	91	and	and	CC
en-wikipedia-org-4107	42	92	adrenoceptor	adrenoceptor	NN
en-wikipedia-org-4107	42	93	α2	α2	XX
en-wikipedia-org-4107	42	94	in	in	IN
en-wikipedia-org-4107	42	95	the	the	DT
en-wikipedia-org-4107	42	96	prefrontal	prefrontal	NNP
en-wikipedia-org-4107	42	97	cortex	cortex	NNP
en-wikipedia-org-4107	42	98	.	.	.
en-wikipedia-org-4107	43	1	[	[	-LRB-
en-wikipedia-org-4107	43	2	26][66	26][66	LS
en-wikipedia-org-4107	43	3	]	]	-RRB-
en-wikipedia-org-4107	43	4	A	a	DT
en-wikipedia-org-4107	43	5	systematic	systematic	JJ
en-wikipedia-org-4107	43	6	review	review	NN
en-wikipedia-org-4107	43	7	from	from	IN
en-wikipedia-org-4107	43	8	2014	2014	CD
en-wikipedia-org-4107	43	9	found	find	VBD
en-wikipedia-org-4107	43	10	that	that	IN
en-wikipedia-org-4107	43	11	low	low	JJ
en-wikipedia-org-4107	43	12	doses	dose	NNS
en-wikipedia-org-4107	43	13	of	of	IN
en-wikipedia-org-4107	43	14	amphetamine	amphetamine	NN
en-wikipedia-org-4107	43	15	also	also	RB
en-wikipedia-org-4107	43	16	improve	improve	VBP
en-wikipedia-org-4107	43	17	memory	memory	NN
en-wikipedia-org-4107	43	18	consolidation	consolidation	NN
en-wikipedia-org-4107	43	19	,	,	,
en-wikipedia-org-4107	43	20	in	in	IN
en-wikipedia-org-4107	43	21	turn	turn	NN
en-wikipedia-org-4107	43	22	leading	lead	VBG
en-wikipedia-org-4107	43	23	to	to	IN
en-wikipedia-org-4107	43	24	improved	improved	JJ
en-wikipedia-org-4107	43	25	recall	recall	NN
en-wikipedia-org-4107	43	26	of	of	IN
en-wikipedia-org-4107	43	27	information	information	NN
en-wikipedia-org-4107	43	28	.	.	.
en-wikipedia-org-4107	44	1	[	[	-LRB-
en-wikipedia-org-4107	44	2	68	68	CD
en-wikipedia-org-4107	44	3	]	]	-RRB-
en-wikipedia-org-4107	44	4	Therapeutic	therapeutic	JJ
en-wikipedia-org-4107	44	5	doses	dose	NNS
en-wikipedia-org-4107	44	6	of	of	IN
en-wikipedia-org-4107	44	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	44	8	also	also	RB
en-wikipedia-org-4107	44	9	enhance	enhance	VB
en-wikipedia-org-4107	44	10	cortical	cortical	JJ
en-wikipedia-org-4107	44	11	network	network	NN
en-wikipedia-org-4107	44	12	efficiency	efficiency	NN
en-wikipedia-org-4107	44	13	,	,	,
en-wikipedia-org-4107	44	14	an	an	DT
en-wikipedia-org-4107	44	15	effect	effect	NN
en-wikipedia-org-4107	44	16	which	which	WDT
en-wikipedia-org-4107	44	17	mediates	mediate	VBZ
en-wikipedia-org-4107	44	18	improvements	improvement	NNS
en-wikipedia-org-4107	44	19	in	in	IN
en-wikipedia-org-4107	44	20	working	work	VBG
en-wikipedia-org-4107	44	21	memory	memory	NN
en-wikipedia-org-4107	44	22	in	in	IN
en-wikipedia-org-4107	44	23	all	all	DT
en-wikipedia-org-4107	44	24	individuals	individual	NNS
en-wikipedia-org-4107	44	25	.	.	.
en-wikipedia-org-4107	45	1	[	[	-LRB-
en-wikipedia-org-4107	45	2	26][69	26][69	CD
en-wikipedia-org-4107	45	3	]	]	-RRB-
en-wikipedia-org-4107	45	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	45	5	and	and	CC
en-wikipedia-org-4107	45	6	other	other	JJ
en-wikipedia-org-4107	45	7	ADHD	ADHD	NNP
en-wikipedia-org-4107	45	8	stimulants	stimulant	NNS
en-wikipedia-org-4107	45	9	also	also	RB
en-wikipedia-org-4107	45	10	improve	improve	VBP
en-wikipedia-org-4107	45	11	task	task	NN
en-wikipedia-org-4107	45	12	saliency	saliency	NN
en-wikipedia-org-4107	45	13	(	(	-LRB-
en-wikipedia-org-4107	45	14	motivation	motivation	NNP
en-wikipedia-org-4107	45	15	to	to	TO
en-wikipedia-org-4107	45	16	perform	perform	VB
en-wikipedia-org-4107	45	17	a	a	DT
en-wikipedia-org-4107	45	18	task	task	NN
en-wikipedia-org-4107	45	19	)	)	-RRB-
en-wikipedia-org-4107	45	20	and	and	CC
en-wikipedia-org-4107	45	21	increase	increase	VB
en-wikipedia-org-4107	45	22	arousal	arousal	NN
en-wikipedia-org-4107	45	23	(	(	-LRB-
en-wikipedia-org-4107	45	24	wakefulness	wakefulness	NN
en-wikipedia-org-4107	45	25	)	)	-RRB-
en-wikipedia-org-4107	45	26	,	,	,
en-wikipedia-org-4107	45	27	in	in	IN
en-wikipedia-org-4107	45	28	turn	turn	NN
en-wikipedia-org-4107	45	29	promoting	promote	VBG
en-wikipedia-org-4107	45	30	goal	goal	NN
en-wikipedia-org-4107	45	31	-	-	HYPH
en-wikipedia-org-4107	45	32	directed	direct	VBN
en-wikipedia-org-4107	45	33	behavior	behavior	NN
en-wikipedia-org-4107	45	34	.	.	.
en-wikipedia-org-4107	46	1	[	[	-LRB-
en-wikipedia-org-4107	46	2	26][70][71	26][70][71	CD
en-wikipedia-org-4107	46	3	]	]	-RRB-
en-wikipedia-org-4107	46	4	Stimulants	stimulant	NNS
en-wikipedia-org-4107	46	5	such	such	JJ
en-wikipedia-org-4107	46	6	as	as	IN
en-wikipedia-org-4107	46	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	46	8	can	can	MD
en-wikipedia-org-4107	46	9	improve	improve	VB
en-wikipedia-org-4107	46	10	performance	performance	NN
en-wikipedia-org-4107	46	11	on	on	IN
en-wikipedia-org-4107	46	12	difficult	difficult	JJ
en-wikipedia-org-4107	46	13	and	and	CC
en-wikipedia-org-4107	46	14	boring	boring	JJ
en-wikipedia-org-4107	46	15	tasks	task	NNS
en-wikipedia-org-4107	46	16	and	and	CC
en-wikipedia-org-4107	46	17	are	be	VBP
en-wikipedia-org-4107	46	18	used	use	VBN
en-wikipedia-org-4107	46	19	by	by	IN
en-wikipedia-org-4107	46	20	some	some	DT
en-wikipedia-org-4107	46	21	students	student	NNS
en-wikipedia-org-4107	46	22	as	as	IN
en-wikipedia-org-4107	46	23	a	a	DT
en-wikipedia-org-4107	46	24	study	study	NN
en-wikipedia-org-4107	46	25	and	and	CC
en-wikipedia-org-4107	46	26	test	test	NN
en-wikipedia-org-4107	46	27	-	-	HYPH
en-wikipedia-org-4107	46	28	taking	take	VBG
en-wikipedia-org-4107	46	29	aid	aid	NN
en-wikipedia-org-4107	46	30	.	.	.
en-wikipedia-org-4107	47	1	[	[	-LRB-
en-wikipedia-org-4107	47	2	26][71][72	26][71][72	CD
en-wikipedia-org-4107	47	3	]	]	-RRB-
en-wikipedia-org-4107	47	4	Based	base	VBN
en-wikipedia-org-4107	47	5	upon	upon	IN
en-wikipedia-org-4107	47	6	studies	study	NNS
en-wikipedia-org-4107	47	7	of	of	IN
en-wikipedia-org-4107	47	8	self	self	NN
en-wikipedia-org-4107	47	9	-	-	HYPH
en-wikipedia-org-4107	47	10	reported	report	VBN
en-wikipedia-org-4107	47	11	illicit	illicit	JJ
en-wikipedia-org-4107	47	12	stimulant	stimulant	NN
en-wikipedia-org-4107	47	13	use	use	NN
en-wikipedia-org-4107	47	14	,	,	,
en-wikipedia-org-4107	47	15	5–35	5–35	JJ
en-wikipedia-org-4107	47	16	%	%	NN
en-wikipedia-org-4107	47	17	of	of	IN
en-wikipedia-org-4107	47	18	college	college	NN
en-wikipedia-org-4107	47	19	students	student	NNS
en-wikipedia-org-4107	47	20	use	use	VBP
en-wikipedia-org-4107	47	21	diverted	divert	VBN
en-wikipedia-org-4107	47	22	ADHD	ADHD	NNP
en-wikipedia-org-4107	47	23	stimulants	stimulant	NNS
en-wikipedia-org-4107	47	24	,	,	,
en-wikipedia-org-4107	47	25	which	which	WDT
en-wikipedia-org-4107	47	26	are	be	VBP
en-wikipedia-org-4107	47	27	primarily	primarily	RB
en-wikipedia-org-4107	47	28	used	use	VBN
en-wikipedia-org-4107	47	29	for	for	IN
en-wikipedia-org-4107	47	30	enhancement	enhancement	NN
en-wikipedia-org-4107	47	31	of	of	IN
en-wikipedia-org-4107	47	32	academic	academic	JJ
en-wikipedia-org-4107	47	33	performance	performance	NN
en-wikipedia-org-4107	47	34	rather	rather	RB
en-wikipedia-org-4107	47	35	than	than	IN
en-wikipedia-org-4107	47	36	as	as	IN
en-wikipedia-org-4107	47	37	recreational	recreational	JJ
en-wikipedia-org-4107	47	38	drugs	drug	NNS
en-wikipedia-org-4107	47	39	.	.	.
en-wikipedia-org-4107	48	1	[	[	-LRB-
en-wikipedia-org-4107	48	2	73][74][75	73][74][75	CD
en-wikipedia-org-4107	48	3	]	]	-RRB-
en-wikipedia-org-4107	48	4	However	however	RB
en-wikipedia-org-4107	48	5	,	,	,
en-wikipedia-org-4107	48	6	high	high	JJ
en-wikipedia-org-4107	48	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	48	8	doses	dose	NNS
en-wikipedia-org-4107	48	9	that	that	WDT
en-wikipedia-org-4107	48	10	are	be	VBP
en-wikipedia-org-4107	48	11	above	above	IN
en-wikipedia-org-4107	48	12	the	the	DT
en-wikipedia-org-4107	48	13	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	48	14	range	range	NN
en-wikipedia-org-4107	48	15	can	can	MD
en-wikipedia-org-4107	48	16	interfere	interfere	VB
en-wikipedia-org-4107	48	17	with	with	IN
en-wikipedia-org-4107	48	18	working	work	VBG
en-wikipedia-org-4107	48	19	memory	memory	NN
en-wikipedia-org-4107	48	20	and	and	CC
en-wikipedia-org-4107	48	21	other	other	JJ
en-wikipedia-org-4107	48	22	aspects	aspect	NNS
en-wikipedia-org-4107	48	23	of	of	IN
en-wikipedia-org-4107	48	24	cognitive	cognitive	JJ
en-wikipedia-org-4107	48	25	control	control	NN
en-wikipedia-org-4107	48	26	.	.	.
en-wikipedia-org-4107	49	1	[	[	-LRB-
en-wikipedia-org-4107	49	2	26][71	26][71	CD
en-wikipedia-org-4107	49	3	]	]	-RRB-
en-wikipedia-org-4107	49	4	Physical	physical	JJ
en-wikipedia-org-4107	49	5	performance	performance	NN
en-wikipedia-org-4107	49	6	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	49	7	is	be	VBZ
en-wikipedia-org-4107	49	8	used	use	VBN
en-wikipedia-org-4107	49	9	by	by	IN
en-wikipedia-org-4107	49	10	some	some	DT
en-wikipedia-org-4107	49	11	athletes	athlete	NNS
en-wikipedia-org-4107	49	12	for	for	IN
en-wikipedia-org-4107	49	13	its	-PRON-	PRP$
en-wikipedia-org-4107	49	14	psychological	psychological	JJ
en-wikipedia-org-4107	49	15	and	and	CC
en-wikipedia-org-4107	49	16	athletic	athletic	JJ
en-wikipedia-org-4107	49	17	performance	performance	NN
en-wikipedia-org-4107	49	18	-	-	HYPH
en-wikipedia-org-4107	49	19	enhancing	enhance	VBG
en-wikipedia-org-4107	49	20	effects	effect	NNS
en-wikipedia-org-4107	49	21	,	,	,
en-wikipedia-org-4107	49	22	such	such	JJ
en-wikipedia-org-4107	49	23	as	as	IN
en-wikipedia-org-4107	49	24	increased	increase	VBN
en-wikipedia-org-4107	49	25	endurance	endurance	NN
en-wikipedia-org-4107	49	26	and	and	CC
en-wikipedia-org-4107	49	27	alertness;[27][39	alertness;[27][39	NN
en-wikipedia-org-4107	49	28	]	]	-RRB-
en-wikipedia-org-4107	49	29	however	however	RB
en-wikipedia-org-4107	49	30	,	,	,
en-wikipedia-org-4107	49	31	non	non	JJ
en-wikipedia-org-4107	49	32	-	-	JJ
en-wikipedia-org-4107	49	33	medical	medical	JJ
en-wikipedia-org-4107	49	34	amphetamine	amphetamine	NN
en-wikipedia-org-4107	49	35	use	use	NN
en-wikipedia-org-4107	49	36	is	be	VBZ
en-wikipedia-org-4107	49	37	prohibited	prohibit	VBN
en-wikipedia-org-4107	49	38	at	at	IN
en-wikipedia-org-4107	49	39	sporting	sporting	NN
en-wikipedia-org-4107	49	40	events	event	NNS
en-wikipedia-org-4107	49	41	that	that	WDT
en-wikipedia-org-4107	49	42	are	be	VBP
en-wikipedia-org-4107	49	43	regulated	regulate	VBN
en-wikipedia-org-4107	49	44	by	by	IN
en-wikipedia-org-4107	49	45	collegiate	collegiate	JJ
en-wikipedia-org-4107	49	46	,	,	,
en-wikipedia-org-4107	49	47	national	national	JJ
en-wikipedia-org-4107	49	48	,	,	,
en-wikipedia-org-4107	49	49	and	and	CC
en-wikipedia-org-4107	49	50	international	international	JJ
en-wikipedia-org-4107	49	51	anti	anti	JJ
en-wikipedia-org-4107	49	52	-	-	JJ
en-wikipedia-org-4107	49	53	doping	doping	JJ
en-wikipedia-org-4107	49	54	agencies	agency	NNS
en-wikipedia-org-4107	49	55	.	.	.
en-wikipedia-org-4107	50	1	[	[	-LRB-
en-wikipedia-org-4107	50	2	76][77	76][77	LS
en-wikipedia-org-4107	50	3	]	]	-RRB-
en-wikipedia-org-4107	50	4	In	in	IN
en-wikipedia-org-4107	50	5	healthy	healthy	JJ
en-wikipedia-org-4107	50	6	people	people	NNS
en-wikipedia-org-4107	50	7	at	at	IN
en-wikipedia-org-4107	50	8	oral	oral	JJ
en-wikipedia-org-4107	50	9	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	50	10	doses	dose	NNS
en-wikipedia-org-4107	50	11	,	,	,
en-wikipedia-org-4107	50	12	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	50	13	has	have	VBZ
en-wikipedia-org-4107	50	14	been	be	VBN
en-wikipedia-org-4107	50	15	shown	show	VBN
en-wikipedia-org-4107	50	16	to	to	TO
en-wikipedia-org-4107	50	17	increase	increase	VB
en-wikipedia-org-4107	50	18	muscle	muscle	NN
en-wikipedia-org-4107	50	19	strength	strength	NN
en-wikipedia-org-4107	50	20	,	,	,
en-wikipedia-org-4107	50	21	acceleration	acceleration	NN
en-wikipedia-org-4107	50	22	,	,	,
en-wikipedia-org-4107	50	23	athletic	athletic	JJ
en-wikipedia-org-4107	50	24	performance	performance	NN
en-wikipedia-org-4107	50	25	in	in	IN
en-wikipedia-org-4107	50	26	anaerobic	anaerobic	JJ
en-wikipedia-org-4107	50	27	conditions	condition	NNS
en-wikipedia-org-4107	50	28	,	,	,
en-wikipedia-org-4107	50	29	and	and	CC
en-wikipedia-org-4107	50	30	endurance	endurance	NN
en-wikipedia-org-4107	50	31	(	(	-LRB-
en-wikipedia-org-4107	50	32	i.e.	i.e.	FW
en-wikipedia-org-4107	50	33	,	,	,
en-wikipedia-org-4107	50	34	it	-PRON-	PRP
en-wikipedia-org-4107	50	35	delays	delay	VBZ
en-wikipedia-org-4107	50	36	the	the	DT
en-wikipedia-org-4107	50	37	onset	onset	NN
en-wikipedia-org-4107	50	38	of	of	IN
en-wikipedia-org-4107	50	39	fatigue	fatigue	NN
en-wikipedia-org-4107	50	40	)	)	-RRB-
en-wikipedia-org-4107	50	41	,	,	,
en-wikipedia-org-4107	50	42	while	while	IN
en-wikipedia-org-4107	50	43	improving	improve	VBG
en-wikipedia-org-4107	50	44	reaction	reaction	NN
en-wikipedia-org-4107	50	45	time	time	NN
en-wikipedia-org-4107	50	46	.	.	.
en-wikipedia-org-4107	51	1	[	[	-LRB-
en-wikipedia-org-4107	51	2	27][78][79	27][78][79	CD
en-wikipedia-org-4107	51	3	]	]	-RRB-
en-wikipedia-org-4107	51	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	51	5	improves	improve	VBZ
en-wikipedia-org-4107	51	6	endurance	endurance	NN
en-wikipedia-org-4107	51	7	and	and	CC
en-wikipedia-org-4107	51	8	reaction	reaction	NN
en-wikipedia-org-4107	51	9	time	time	NN
en-wikipedia-org-4107	51	10	primarily	primarily	RB
en-wikipedia-org-4107	51	11	through	through	IN
en-wikipedia-org-4107	51	12	reuptake	reuptake	NN
en-wikipedia-org-4107	51	13	inhibition	inhibition	NN
en-wikipedia-org-4107	51	14	and	and	CC
en-wikipedia-org-4107	51	15	release	release	NN
en-wikipedia-org-4107	51	16	of	of	IN
en-wikipedia-org-4107	51	17	dopamine	dopamine	NN
en-wikipedia-org-4107	51	18	in	in	IN
en-wikipedia-org-4107	51	19	the	the	DT
en-wikipedia-org-4107	51	20	central	central	JJ
en-wikipedia-org-4107	51	21	nervous	nervous	JJ
en-wikipedia-org-4107	51	22	system	system	NN
en-wikipedia-org-4107	51	23	.	.	.
en-wikipedia-org-4107	52	1	[	[	-LRB-
en-wikipedia-org-4107	52	2	78][79][80	78][79][80	CD
en-wikipedia-org-4107	52	3	]	]	-RRB-
en-wikipedia-org-4107	52	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	52	5	and	and	CC
en-wikipedia-org-4107	52	6	other	other	JJ
en-wikipedia-org-4107	52	7	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	52	8	drugs	drug	NNS
en-wikipedia-org-4107	52	9	also	also	RB
en-wikipedia-org-4107	52	10	increase	increase	VBP
en-wikipedia-org-4107	52	11	power	power	NN
en-wikipedia-org-4107	52	12	output	output	NN
en-wikipedia-org-4107	52	13	at	at	IN
en-wikipedia-org-4107	52	14	fixed	fix	VBN
en-wikipedia-org-4107	52	15	levels	level	NNS
en-wikipedia-org-4107	52	16	of	of	IN
en-wikipedia-org-4107	52	17	perceived	perceive	VBN
en-wikipedia-org-4107	52	18	exertion	exertion	NN
en-wikipedia-org-4107	52	19	by	by	IN
en-wikipedia-org-4107	52	20	overriding	override	VBG
en-wikipedia-org-4107	52	21	a	a	DT
en-wikipedia-org-4107	52	22	"	"	``
en-wikipedia-org-4107	52	23	safety	safety	NN
en-wikipedia-org-4107	52	24	switch	switch	NN
en-wikipedia-org-4107	52	25	"	"	''
en-wikipedia-org-4107	52	26	,	,	,
en-wikipedia-org-4107	52	27	allowing	allow	VBG
en-wikipedia-org-4107	52	28	the	the	DT
en-wikipedia-org-4107	52	29	core	core	NN
en-wikipedia-org-4107	52	30	temperature	temperature	NN
en-wikipedia-org-4107	52	31	limit	limit	NN
en-wikipedia-org-4107	52	32	to	to	TO
en-wikipedia-org-4107	52	33	increase	increase	VB
en-wikipedia-org-4107	52	34	in	in	IN
en-wikipedia-org-4107	52	35	order	order	NN
en-wikipedia-org-4107	52	36	to	to	TO
en-wikipedia-org-4107	52	37	access	access	VB
en-wikipedia-org-4107	52	38	a	a	DT
en-wikipedia-org-4107	52	39	reserve	reserve	NN
en-wikipedia-org-4107	52	40	capacity	capacity	NN
en-wikipedia-org-4107	52	41	that	that	WDT
en-wikipedia-org-4107	52	42	is	be	VBZ
en-wikipedia-org-4107	52	43	normally	normally	RB
en-wikipedia-org-4107	52	44	off	off	IN
en-wikipedia-org-4107	52	45	-	-	HYPH
en-wikipedia-org-4107	52	46	limits	limit	NNS
en-wikipedia-org-4107	52	47	.	.	.
en-wikipedia-org-4107	53	1	[	[	-LRB-
en-wikipedia-org-4107	53	2	79][81][82	79][81][82	CD
en-wikipedia-org-4107	53	3	]	]	-RRB-
en-wikipedia-org-4107	53	4	At	at	IN
en-wikipedia-org-4107	53	5	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	53	6	doses	dose	NNS
en-wikipedia-org-4107	53	7	,	,	,
en-wikipedia-org-4107	53	8	the	the	DT
en-wikipedia-org-4107	53	9	adverse	adverse	JJ
en-wikipedia-org-4107	53	10	effects	effect	NNS
en-wikipedia-org-4107	53	11	of	of	IN
en-wikipedia-org-4107	53	12	amphetamine	amphetamine	NN
en-wikipedia-org-4107	53	13	do	do	VBP
en-wikipedia-org-4107	53	14	not	not	RB
en-wikipedia-org-4107	53	15	impede	impede	VB
en-wikipedia-org-4107	53	16	athletic	athletic	JJ
en-wikipedia-org-4107	53	17	performance;[27][78	performance;[27][78	NNS
en-wikipedia-org-4107	53	18	]	]	-RRB-
en-wikipedia-org-4107	53	19	however	however	RB
en-wikipedia-org-4107	53	20	,	,	,
en-wikipedia-org-4107	53	21	at	at	IN
en-wikipedia-org-4107	53	22	much	much	RB
en-wikipedia-org-4107	53	23	higher	high	JJR
en-wikipedia-org-4107	53	24	doses	dose	NNS
en-wikipedia-org-4107	53	25	,	,	,
en-wikipedia-org-4107	53	26	amphetamine	amphetamine	NN
en-wikipedia-org-4107	53	27	can	can	MD
en-wikipedia-org-4107	53	28	induce	induce	VB
en-wikipedia-org-4107	53	29	effects	effect	NNS
en-wikipedia-org-4107	53	30	that	that	WDT
en-wikipedia-org-4107	53	31	severely	severely	RB
en-wikipedia-org-4107	53	32	impair	impair	VBP
en-wikipedia-org-4107	53	33	performance	performance	NN
en-wikipedia-org-4107	53	34	,	,	,
en-wikipedia-org-4107	53	35	such	such	JJ
en-wikipedia-org-4107	53	36	as	as	IN
en-wikipedia-org-4107	53	37	rapid	rapid	JJ
en-wikipedia-org-4107	53	38	muscle	muscle	NN
en-wikipedia-org-4107	53	39	breakdown	breakdown	NN
en-wikipedia-org-4107	53	40	and	and	CC
en-wikipedia-org-4107	53	41	elevated	elevated	JJ
en-wikipedia-org-4107	53	42	body	body	NN
en-wikipedia-org-4107	53	43	temperature	temperature	NN
en-wikipedia-org-4107	53	44	.	.	.
en-wikipedia-org-4107	54	1	[	[	-LRB-
en-wikipedia-org-4107	54	2	28][78	28][78	CD
en-wikipedia-org-4107	54	3	]	]	-RRB-
en-wikipedia-org-4107	54	4	Contraindications	contraindication	NNS
en-wikipedia-org-4107	54	5	See	see	VB
en-wikipedia-org-4107	54	6	also	also	RB
en-wikipedia-org-4107	54	7	:	:	:
en-wikipedia-org-4107	54	8	Amphetamine	amphetamine	NN
en-wikipedia-org-4107	54	9	§	§	ADD
en-wikipedia-org-4107	54	10	 	  	_SP
en-wikipedia-org-4107	54	11	Drug	drug	NN
en-wikipedia-org-4107	54	12	interactions	interaction	NNS
en-wikipedia-org-4107	54	13	According	accord	VBG
en-wikipedia-org-4107	54	14	to	to	IN
en-wikipedia-org-4107	54	15	the	the	DT
en-wikipedia-org-4107	54	16	International	International	NNP
en-wikipedia-org-4107	54	17	Programme	Programme	NNP
en-wikipedia-org-4107	54	18	on	on	IN
en-wikipedia-org-4107	54	19	Chemical	Chemical	NNP
en-wikipedia-org-4107	54	20	Safety	Safety	NNP
en-wikipedia-org-4107	54	21	(	(	-LRB-
en-wikipedia-org-4107	54	22	IPCS	IPCS	NNP
en-wikipedia-org-4107	54	23	)	)	-RRB-
en-wikipedia-org-4107	54	24	and	and	CC
en-wikipedia-org-4107	54	25	the	the	DT
en-wikipedia-org-4107	54	26	United	United	NNP
en-wikipedia-org-4107	54	27	States	States	NNP
en-wikipedia-org-4107	54	28	Food	Food	NNP
en-wikipedia-org-4107	54	29	and	and	CC
en-wikipedia-org-4107	54	30	Drug	Drug	NNP
en-wikipedia-org-4107	54	31	Administration	Administration	NNP
en-wikipedia-org-4107	54	32	(	(	-LRB-
en-wikipedia-org-4107	54	33	USFDA),[note	USFDA),[note	NNP
en-wikipedia-org-4107	54	34	8	8	CD
en-wikipedia-org-4107	54	35	]	]	-RRB-
en-wikipedia-org-4107	54	36	amphetamine	amphetamine	NN
en-wikipedia-org-4107	54	37	is	be	VBZ
en-wikipedia-org-4107	54	38	contraindicated	contraindicate	VBN
en-wikipedia-org-4107	54	39	in	in	IN
en-wikipedia-org-4107	54	40	people	people	NNS
en-wikipedia-org-4107	54	41	with	with	IN
en-wikipedia-org-4107	54	42	a	a	DT
en-wikipedia-org-4107	54	43	history	history	NN
en-wikipedia-org-4107	54	44	of	of	IN
en-wikipedia-org-4107	54	45	drug	drug	NN
en-wikipedia-org-4107	54	46	abuse,[note	abuse,[note	CD
en-wikipedia-org-4107	54	47	9	9	CD
en-wikipedia-org-4107	54	48	]	]	-RRB-
en-wikipedia-org-4107	54	49	cardiovascular	cardiovascular	JJ
en-wikipedia-org-4107	54	50	disease	disease	NN
en-wikipedia-org-4107	54	51	,	,	,
en-wikipedia-org-4107	54	52	severe	severe	JJ
en-wikipedia-org-4107	54	53	agitation	agitation	NN
en-wikipedia-org-4107	54	54	,	,	,
en-wikipedia-org-4107	54	55	or	or	CC
en-wikipedia-org-4107	54	56	severe	severe	JJ
en-wikipedia-org-4107	54	57	anxiety	anxiety	NN
en-wikipedia-org-4107	54	58	.	.	.
en-wikipedia-org-4107	55	1	[	[	-LRB-
en-wikipedia-org-4107	55	2	35][28][84	35][28][84	CD
en-wikipedia-org-4107	55	3	]	]	-RRB-
en-wikipedia-org-4107	55	4	It	-PRON-	PRP
en-wikipedia-org-4107	55	5	is	be	VBZ
en-wikipedia-org-4107	55	6	also	also	RB
en-wikipedia-org-4107	55	7	contraindicated	contraindicate	VBN
en-wikipedia-org-4107	55	8	in	in	IN
en-wikipedia-org-4107	55	9	individuals	individual	NNS
en-wikipedia-org-4107	55	10	with	with	IN
en-wikipedia-org-4107	55	11	advanced	advanced	JJ
en-wikipedia-org-4107	55	12	arteriosclerosis	arteriosclerosis	NN
en-wikipedia-org-4107	55	13	(	(	-LRB-
en-wikipedia-org-4107	55	14	hardening	harden	VBG
en-wikipedia-org-4107	55	15	of	of	IN
en-wikipedia-org-4107	55	16	the	the	DT
en-wikipedia-org-4107	55	17	arteries	artery	NNS
en-wikipedia-org-4107	55	18	)	)	-RRB-
en-wikipedia-org-4107	55	19	,	,	,
en-wikipedia-org-4107	55	20	glaucoma	glaucoma	NNP
en-wikipedia-org-4107	55	21	(	(	-LRB-
en-wikipedia-org-4107	55	22	increased	increase	VBN
en-wikipedia-org-4107	55	23	eye	eye	NN
en-wikipedia-org-4107	55	24	pressure	pressure	NN
en-wikipedia-org-4107	55	25	)	)	-RRB-
en-wikipedia-org-4107	55	26	,	,	,
en-wikipedia-org-4107	55	27	hyperthyroidism	hyperthyroidism	NN
en-wikipedia-org-4107	55	28	(	(	-LRB-
en-wikipedia-org-4107	55	29	excessive	excessive	JJ
en-wikipedia-org-4107	55	30	production	production	NN
en-wikipedia-org-4107	55	31	of	of	IN
en-wikipedia-org-4107	55	32	thyroid	thyroid	NN
en-wikipedia-org-4107	55	33	hormone	hormone	NN
en-wikipedia-org-4107	55	34	)	)	-RRB-
en-wikipedia-org-4107	55	35	,	,	,
en-wikipedia-org-4107	55	36	or	or	CC
en-wikipedia-org-4107	55	37	moderate	moderate	JJ
en-wikipedia-org-4107	55	38	to	to	IN
en-wikipedia-org-4107	55	39	severe	severe	JJ
en-wikipedia-org-4107	55	40	hypertension	hypertension	NN
en-wikipedia-org-4107	55	41	.	.	.
en-wikipedia-org-4107	56	1	[	[	-LRB-
en-wikipedia-org-4107	56	2	35][28][84	35][28][84	CD
en-wikipedia-org-4107	56	3	]	]	-RRB-
en-wikipedia-org-4107	56	4	These	these	DT
en-wikipedia-org-4107	56	5	agencies	agency	NNS
en-wikipedia-org-4107	56	6	indicate	indicate	VBP
en-wikipedia-org-4107	56	7	that	that	IN
en-wikipedia-org-4107	56	8	people	people	NNS
en-wikipedia-org-4107	56	9	who	who	WP
en-wikipedia-org-4107	56	10	have	have	VBP
en-wikipedia-org-4107	56	11	experienced	experience	VBN
en-wikipedia-org-4107	56	12	allergic	allergic	JJ
en-wikipedia-org-4107	56	13	reactions	reaction	NNS
en-wikipedia-org-4107	56	14	to	to	IN
en-wikipedia-org-4107	56	15	other	other	JJ
en-wikipedia-org-4107	56	16	stimulants	stimulant	NNS
en-wikipedia-org-4107	56	17	or	or	CC
en-wikipedia-org-4107	56	18	who	who	WP
en-wikipedia-org-4107	56	19	are	be	VBP
en-wikipedia-org-4107	56	20	taking	take	VBG
en-wikipedia-org-4107	56	21	monoamine	monoamine	NN
en-wikipedia-org-4107	56	22	oxidase	oxidase	NN
en-wikipedia-org-4107	56	23	inhibitors	inhibitor	NNS
en-wikipedia-org-4107	56	24	(	(	-LRB-
en-wikipedia-org-4107	56	25	MAOIs	MAOIs	NNP
en-wikipedia-org-4107	56	26	)	)	-RRB-
en-wikipedia-org-4107	56	27	should	should	MD
en-wikipedia-org-4107	56	28	not	not	RB
en-wikipedia-org-4107	56	29	take	take	VB
en-wikipedia-org-4107	56	30	amphetamine,[35][28][84	amphetamine,[35][28][84	NNP
en-wikipedia-org-4107	56	31	]	]	-RRB-
en-wikipedia-org-4107	56	32	although	although	IN
en-wikipedia-org-4107	56	33	safe	safe	JJ
en-wikipedia-org-4107	56	34	concurrent	concurrent	JJ
en-wikipedia-org-4107	56	35	use	use	NN
en-wikipedia-org-4107	56	36	of	of	IN
en-wikipedia-org-4107	56	37	amphetamine	amphetamine	NN
en-wikipedia-org-4107	56	38	and	and	CC
en-wikipedia-org-4107	56	39	monoamine	monoamine	NNP
en-wikipedia-org-4107	56	40	oxidase	oxidase	NNP
en-wikipedia-org-4107	56	41	inhibitors	inhibitor	NNS
en-wikipedia-org-4107	56	42	has	have	VBZ
en-wikipedia-org-4107	56	43	been	be	VBN
en-wikipedia-org-4107	56	44	documented	document	VBN
en-wikipedia-org-4107	56	45	.	.	.
en-wikipedia-org-4107	57	1	[	[	-LRB-
en-wikipedia-org-4107	57	2	85][86	85][86	CD
en-wikipedia-org-4107	57	3	]	]	-RRB-
en-wikipedia-org-4107	57	4	These	these	DT
en-wikipedia-org-4107	57	5	agencies	agency	NNS
en-wikipedia-org-4107	57	6	also	also	RB
en-wikipedia-org-4107	57	7	state	state	VBP
en-wikipedia-org-4107	57	8	that	that	IN
en-wikipedia-org-4107	57	9	anyone	anyone	NN
en-wikipedia-org-4107	57	10	with	with	IN
en-wikipedia-org-4107	57	11	anorexia	anorexia	NNP
en-wikipedia-org-4107	57	12	nervosa	nervosa	NNP
en-wikipedia-org-4107	57	13	,	,	,
en-wikipedia-org-4107	57	14	bipolar	bipolar	JJ
en-wikipedia-org-4107	57	15	disorder	disorder	NN
en-wikipedia-org-4107	57	16	,	,	,
en-wikipedia-org-4107	57	17	depression	depression	NN
en-wikipedia-org-4107	57	18	,	,	,
en-wikipedia-org-4107	57	19	hypertension	hypertension	NN
en-wikipedia-org-4107	57	20	,	,	,
en-wikipedia-org-4107	57	21	liver	liver	NN
en-wikipedia-org-4107	57	22	or	or	CC
en-wikipedia-org-4107	57	23	kidney	kidney	NN
en-wikipedia-org-4107	57	24	problems	problem	NNS
en-wikipedia-org-4107	57	25	,	,	,
en-wikipedia-org-4107	57	26	mania	mania	NN
en-wikipedia-org-4107	57	27	,	,	,
en-wikipedia-org-4107	57	28	psychosis	psychosis	NN
en-wikipedia-org-4107	57	29	,	,	,
en-wikipedia-org-4107	57	30	Raynaud	Raynaud	NNP
en-wikipedia-org-4107	57	31	's	's	POS
en-wikipedia-org-4107	57	32	phenomenon	phenomenon	NN
en-wikipedia-org-4107	57	33	,	,	,
en-wikipedia-org-4107	57	34	seizures	seizure	NNS
en-wikipedia-org-4107	57	35	,	,	,
en-wikipedia-org-4107	57	36	thyroid	thyroid	NN
en-wikipedia-org-4107	57	37	problems	problem	NNS
en-wikipedia-org-4107	57	38	,	,	,
en-wikipedia-org-4107	57	39	tics	tic	NNS
en-wikipedia-org-4107	57	40	,	,	,
en-wikipedia-org-4107	57	41	or	or	CC
en-wikipedia-org-4107	57	42	Tourette	Tourette	NNP
en-wikipedia-org-4107	57	43	syndrome	syndrome	NN
en-wikipedia-org-4107	57	44	should	should	MD
en-wikipedia-org-4107	57	45	monitor	monitor	VB
en-wikipedia-org-4107	57	46	their	-PRON-	PRP$
en-wikipedia-org-4107	57	47	symptoms	symptom	NNS
en-wikipedia-org-4107	57	48	while	while	IN
en-wikipedia-org-4107	57	49	taking	take	VBG
en-wikipedia-org-4107	57	50	amphetamine	amphetamine	NN
en-wikipedia-org-4107	57	51	.	.	.
en-wikipedia-org-4107	58	1	[	[	-LRB-
en-wikipedia-org-4107	58	2	28][84	28][84	CD
en-wikipedia-org-4107	58	3	]	]	-RRB-
en-wikipedia-org-4107	58	4	Evidence	evidence	NN
en-wikipedia-org-4107	58	5	from	from	IN
en-wikipedia-org-4107	58	6	human	human	JJ
en-wikipedia-org-4107	58	7	studies	study	NNS
en-wikipedia-org-4107	58	8	indicates	indicate	VBZ
en-wikipedia-org-4107	58	9	that	that	IN
en-wikipedia-org-4107	58	10	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	58	11	amphetamine	amphetamine	NN
en-wikipedia-org-4107	58	12	use	use	NN
en-wikipedia-org-4107	58	13	does	do	VBZ
en-wikipedia-org-4107	58	14	not	not	RB
en-wikipedia-org-4107	58	15	cause	cause	VB
en-wikipedia-org-4107	58	16	developmental	developmental	JJ
en-wikipedia-org-4107	58	17	abnormalities	abnormality	NNS
en-wikipedia-org-4107	58	18	in	in	IN
en-wikipedia-org-4107	58	19	the	the	DT
en-wikipedia-org-4107	58	20	fetus	fetus	NN
en-wikipedia-org-4107	58	21	or	or	CC
en-wikipedia-org-4107	58	22	newborns	newborn	NNS
en-wikipedia-org-4107	58	23	(	(	-LRB-
en-wikipedia-org-4107	58	24	i.e.	i.e.	FW
en-wikipedia-org-4107	58	25	,	,	,
en-wikipedia-org-4107	58	26	it	-PRON-	PRP
en-wikipedia-org-4107	58	27	is	be	VBZ
en-wikipedia-org-4107	58	28	not	not	RB
en-wikipedia-org-4107	58	29	a	a	DT
en-wikipedia-org-4107	58	30	human	human	JJ
en-wikipedia-org-4107	58	31	teratogen	teratogen	NN
en-wikipedia-org-4107	58	32	)	)	-RRB-
en-wikipedia-org-4107	58	33	,	,	,
en-wikipedia-org-4107	58	34	but	but	CC
en-wikipedia-org-4107	58	35	amphetamine	amphetamine	VB
en-wikipedia-org-4107	58	36	abuse	abuse	NN
en-wikipedia-org-4107	58	37	does	do	VBZ
en-wikipedia-org-4107	58	38	pose	pose	VB
en-wikipedia-org-4107	58	39	risks	risk	NNS
en-wikipedia-org-4107	58	40	to	to	IN
en-wikipedia-org-4107	58	41	the	the	DT
en-wikipedia-org-4107	58	42	fetus	fetus	NN
en-wikipedia-org-4107	58	43	.	.	.
en-wikipedia-org-4107	59	1	[	[	-LRB-
en-wikipedia-org-4107	59	2	84	84	CD
en-wikipedia-org-4107	59	3	]	]	-RRB-
en-wikipedia-org-4107	59	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	59	5	has	have	VBZ
en-wikipedia-org-4107	59	6	also	also	RB
en-wikipedia-org-4107	59	7	been	be	VBN
en-wikipedia-org-4107	59	8	shown	show	VBN
en-wikipedia-org-4107	59	9	to	to	TO
en-wikipedia-org-4107	59	10	pass	pass	VB
en-wikipedia-org-4107	59	11	into	into	IN
en-wikipedia-org-4107	59	12	breast	breast	NN
en-wikipedia-org-4107	59	13	milk	milk	NN
en-wikipedia-org-4107	59	14	,	,	,
en-wikipedia-org-4107	59	15	so	so	RB
en-wikipedia-org-4107	59	16	the	the	DT
en-wikipedia-org-4107	59	17	IPCS	IPCS	NNP
en-wikipedia-org-4107	59	18	and	and	CC
en-wikipedia-org-4107	59	19	the	the	DT
en-wikipedia-org-4107	59	20	USFDA	USFDA	NNP
en-wikipedia-org-4107	59	21	advise	advise	VBP
en-wikipedia-org-4107	59	22	mothers	mother	NNS
en-wikipedia-org-4107	59	23	to	to	TO
en-wikipedia-org-4107	59	24	avoid	avoid	VB
en-wikipedia-org-4107	59	25	breastfeeding	breastfeed	VBG
en-wikipedia-org-4107	59	26	when	when	WRB
en-wikipedia-org-4107	59	27	using	use	VBG
en-wikipedia-org-4107	59	28	it	-PRON-	PRP
en-wikipedia-org-4107	59	29	.	.	.
en-wikipedia-org-4107	60	1	[	[	-LRB-
en-wikipedia-org-4107	60	2	28][84	28][84	CD
en-wikipedia-org-4107	60	3	]	]	-RRB-
en-wikipedia-org-4107	60	4	Due	due	IN
en-wikipedia-org-4107	60	5	to	to	IN
en-wikipedia-org-4107	60	6	the	the	DT
en-wikipedia-org-4107	60	7	potential	potential	NN
en-wikipedia-org-4107	60	8	for	for	IN
en-wikipedia-org-4107	60	9	reversible	reversible	JJ
en-wikipedia-org-4107	60	10	growth	growth	NN
en-wikipedia-org-4107	60	11	impairments,[note	impairments,[note	-LRB-
en-wikipedia-org-4107	60	12	10	10	CD
en-wikipedia-org-4107	60	13	]	]	-RRB-
en-wikipedia-org-4107	60	14	the	the	DT
en-wikipedia-org-4107	60	15	USFDA	USFDA	NNP
en-wikipedia-org-4107	60	16	advises	advise	VBZ
en-wikipedia-org-4107	60	17	monitoring	monitor	VBG
en-wikipedia-org-4107	60	18	the	the	DT
en-wikipedia-org-4107	60	19	height	height	NN
en-wikipedia-org-4107	60	20	and	and	CC
en-wikipedia-org-4107	60	21	weight	weight	NN
en-wikipedia-org-4107	60	22	of	of	IN
en-wikipedia-org-4107	60	23	children	child	NNS
en-wikipedia-org-4107	60	24	and	and	CC
en-wikipedia-org-4107	60	25	adolescents	adolescent	NNS
en-wikipedia-org-4107	60	26	prescribed	prescribe	VBD
en-wikipedia-org-4107	60	27	an	an	DT
en-wikipedia-org-4107	60	28	amphetamine	amphetamine	NN
en-wikipedia-org-4107	60	29	pharmaceutical	pharmaceutical	NN
en-wikipedia-org-4107	60	30	.	.	.
en-wikipedia-org-4107	61	1	[	[	-LRB-
en-wikipedia-org-4107	61	2	28	28	CD
en-wikipedia-org-4107	61	3	]	]	-RRB-
en-wikipedia-org-4107	61	4	Adverse	adverse	JJ
en-wikipedia-org-4107	61	5	effects	effect	NNS
en-wikipedia-org-4107	61	6	The	the	DT
en-wikipedia-org-4107	61	7	adverse	adverse	JJ
en-wikipedia-org-4107	61	8	side	side	NN
en-wikipedia-org-4107	61	9	effects	effect	NNS
en-wikipedia-org-4107	61	10	of	of	IN
en-wikipedia-org-4107	61	11	amphetamine	amphetamine	NN
en-wikipedia-org-4107	61	12	are	be	VBP
en-wikipedia-org-4107	61	13	many	many	JJ
en-wikipedia-org-4107	61	14	and	and	CC
en-wikipedia-org-4107	61	15	varied	varied	JJ
en-wikipedia-org-4107	61	16	,	,	,
en-wikipedia-org-4107	61	17	and	and	CC
en-wikipedia-org-4107	61	18	the	the	DT
en-wikipedia-org-4107	61	19	amount	amount	NN
en-wikipedia-org-4107	61	20	of	of	IN
en-wikipedia-org-4107	61	21	amphetamine	amphetamine	NN
en-wikipedia-org-4107	61	22	used	use	VBN
en-wikipedia-org-4107	61	23	is	be	VBZ
en-wikipedia-org-4107	61	24	the	the	DT
en-wikipedia-org-4107	61	25	primary	primary	JJ
en-wikipedia-org-4107	61	26	factor	factor	NN
en-wikipedia-org-4107	61	27	in	in	IN
en-wikipedia-org-4107	61	28	determining	determine	VBG
en-wikipedia-org-4107	61	29	the	the	DT
en-wikipedia-org-4107	61	30	likelihood	likelihood	NN
en-wikipedia-org-4107	61	31	and	and	CC
en-wikipedia-org-4107	61	32	severity	severity	NN
en-wikipedia-org-4107	61	33	of	of	IN
en-wikipedia-org-4107	61	34	adverse	adverse	JJ
en-wikipedia-org-4107	61	35	effects	effect	NNS
en-wikipedia-org-4107	61	36	.	.	.
en-wikipedia-org-4107	62	1	[	[	-LRB-
en-wikipedia-org-4107	62	2	28][39	28][39	LS
en-wikipedia-org-4107	62	3	]	]	-RRB-
en-wikipedia-org-4107	62	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	62	5	products	product	NNS
en-wikipedia-org-4107	62	6	such	such	JJ
en-wikipedia-org-4107	62	7	as	as	IN
en-wikipedia-org-4107	62	8	Adderall	Adderall	NNP
en-wikipedia-org-4107	62	9	,	,	,
en-wikipedia-org-4107	62	10	Dexedrine	Dexedrine	NNP
en-wikipedia-org-4107	62	11	,	,	,
en-wikipedia-org-4107	62	12	and	and	CC
en-wikipedia-org-4107	62	13	their	-PRON-	PRP$
en-wikipedia-org-4107	62	14	generic	generic	JJ
en-wikipedia-org-4107	62	15	equivalents	equivalent	NNS
en-wikipedia-org-4107	62	16	are	be	VBP
en-wikipedia-org-4107	62	17	currently	currently	RB
en-wikipedia-org-4107	62	18	approved	approve	VBN
en-wikipedia-org-4107	62	19	by	by	IN
en-wikipedia-org-4107	62	20	the	the	DT
en-wikipedia-org-4107	62	21	USFDA	USFDA	NNP
en-wikipedia-org-4107	62	22	for	for	IN
en-wikipedia-org-4107	62	23	long	long	JJ
en-wikipedia-org-4107	62	24	-	-	HYPH
en-wikipedia-org-4107	62	25	term	term	NN
en-wikipedia-org-4107	62	26	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	62	27	use	use	NN
en-wikipedia-org-4107	62	28	.	.	.
en-wikipedia-org-4107	63	1	[	[	-LRB-
en-wikipedia-org-4107	63	2	36][28	36][28	LS
en-wikipedia-org-4107	63	3	]	]	-RRB-
en-wikipedia-org-4107	63	4	Recreational	recreational	JJ
en-wikipedia-org-4107	63	5	use	use	NN
en-wikipedia-org-4107	63	6	of	of	IN
en-wikipedia-org-4107	63	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	63	8	generally	generally	RB
en-wikipedia-org-4107	63	9	involves	involve	VBZ
en-wikipedia-org-4107	63	10	much	much	RB
en-wikipedia-org-4107	63	11	larger	large	JJR
en-wikipedia-org-4107	63	12	doses	dose	NNS
en-wikipedia-org-4107	63	13	,	,	,
en-wikipedia-org-4107	63	14	which	which	WDT
en-wikipedia-org-4107	63	15	have	have	VBP
en-wikipedia-org-4107	63	16	a	a	DT
en-wikipedia-org-4107	63	17	greater	great	JJR
en-wikipedia-org-4107	63	18	risk	risk	NN
en-wikipedia-org-4107	63	19	of	of	IN
en-wikipedia-org-4107	63	20	serious	serious	JJ
en-wikipedia-org-4107	63	21	adverse	adverse	JJ
en-wikipedia-org-4107	63	22	drug	drug	NN
en-wikipedia-org-4107	63	23	effects	effect	NNS
en-wikipedia-org-4107	63	24	than	than	IN
en-wikipedia-org-4107	63	25	dosages	dosage	NNS
en-wikipedia-org-4107	63	26	used	use	VBN
en-wikipedia-org-4107	63	27	for	for	IN
en-wikipedia-org-4107	63	28	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	63	29	purposes	purpose	NNS
en-wikipedia-org-4107	63	30	.	.	.
en-wikipedia-org-4107	64	1	[	[	-LRB-
en-wikipedia-org-4107	64	2	39	39	CD
en-wikipedia-org-4107	64	3	]	]	-RRB-
en-wikipedia-org-4107	64	4	Physical	Physical	NNP
en-wikipedia-org-4107	64	5	Cardiovascular	Cardiovascular	NNP
en-wikipedia-org-4107	64	6	side	side	NN
en-wikipedia-org-4107	64	7	effects	effect	NNS
en-wikipedia-org-4107	64	8	can	can	MD
en-wikipedia-org-4107	64	9	include	include	VB
en-wikipedia-org-4107	64	10	hypertension	hypertension	NN
en-wikipedia-org-4107	64	11	or	or	CC
en-wikipedia-org-4107	64	12	hypotension	hypotension	NN
en-wikipedia-org-4107	64	13	from	from	IN
en-wikipedia-org-4107	64	14	a	a	DT
en-wikipedia-org-4107	64	15	vasovagal	vasovagal	JJ
en-wikipedia-org-4107	64	16	response	response	NN
en-wikipedia-org-4107	64	17	,	,	,
en-wikipedia-org-4107	64	18	Raynaud	Raynaud	NNP
en-wikipedia-org-4107	64	19	's	's	POS
en-wikipedia-org-4107	64	20	phenomenon	phenomenon	NN
en-wikipedia-org-4107	64	21	(	(	-LRB-
en-wikipedia-org-4107	64	22	reduced	reduce	VBN
en-wikipedia-org-4107	64	23	blood	blood	NN
en-wikipedia-org-4107	64	24	flow	flow	NN
en-wikipedia-org-4107	64	25	to	to	IN
en-wikipedia-org-4107	64	26	the	the	DT
en-wikipedia-org-4107	64	27	hands	hand	NNS
en-wikipedia-org-4107	64	28	and	and	CC
en-wikipedia-org-4107	64	29	feet	foot	NNS
en-wikipedia-org-4107	64	30	)	)	-RRB-
en-wikipedia-org-4107	64	31	,	,	,
en-wikipedia-org-4107	64	32	and	and	CC
en-wikipedia-org-4107	64	33	tachycardia	tachycardia	NN
en-wikipedia-org-4107	64	34	(	(	-LRB-
en-wikipedia-org-4107	64	35	increased	increase	VBN
en-wikipedia-org-4107	64	36	heart	heart	NN
en-wikipedia-org-4107	64	37	rate	rate	NN
en-wikipedia-org-4107	64	38	)	)	-RRB-
en-wikipedia-org-4107	64	39	.	.	.
en-wikipedia-org-4107	65	1	[	[	-LRB-
en-wikipedia-org-4107	65	2	28][39][87	28][39][87	CD
en-wikipedia-org-4107	65	3	]	]	-RRB-
en-wikipedia-org-4107	65	4	Sexual	sexual	JJ
en-wikipedia-org-4107	65	5	side	side	NN
en-wikipedia-org-4107	65	6	effects	effect	NNS
en-wikipedia-org-4107	65	7	in	in	IN
en-wikipedia-org-4107	65	8	males	male	NNS
en-wikipedia-org-4107	65	9	may	may	MD
en-wikipedia-org-4107	65	10	include	include	VB
en-wikipedia-org-4107	65	11	erectile	erectile	JJ
en-wikipedia-org-4107	65	12	dysfunction	dysfunction	NN
en-wikipedia-org-4107	65	13	,	,	,
en-wikipedia-org-4107	65	14	frequent	frequent	JJ
en-wikipedia-org-4107	65	15	erections	erection	NNS
en-wikipedia-org-4107	65	16	,	,	,
en-wikipedia-org-4107	65	17	or	or	CC
en-wikipedia-org-4107	65	18	prolonged	prolong	VBN
en-wikipedia-org-4107	65	19	erections	erection	NNS
en-wikipedia-org-4107	65	20	.	.	.
en-wikipedia-org-4107	66	1	[	[	-LRB-
en-wikipedia-org-4107	66	2	28	28	CD
en-wikipedia-org-4107	66	3	]	]	-RRB-
en-wikipedia-org-4107	66	4	Gastrointestinal	gastrointestinal	JJ
en-wikipedia-org-4107	66	5	side	side	NN
en-wikipedia-org-4107	66	6	effects	effect	NNS
en-wikipedia-org-4107	66	7	may	may	MD
en-wikipedia-org-4107	66	8	include	include	VB
en-wikipedia-org-4107	66	9	abdominal	abdominal	JJ
en-wikipedia-org-4107	66	10	pain	pain	NN
en-wikipedia-org-4107	66	11	,	,	,
en-wikipedia-org-4107	66	12	constipation	constipation	NN
en-wikipedia-org-4107	66	13	,	,	,
en-wikipedia-org-4107	66	14	diarrhea	diarrhea	NN
en-wikipedia-org-4107	66	15	,	,	,
en-wikipedia-org-4107	66	16	and	and	CC
en-wikipedia-org-4107	66	17	nausea	nausea	NN
en-wikipedia-org-4107	66	18	.	.	.
en-wikipedia-org-4107	67	1	[	[	-LRB-
en-wikipedia-org-4107	67	2	2][28][88	2][28][88	CD
en-wikipedia-org-4107	67	3	]	]	-RRB-
en-wikipedia-org-4107	67	4	Other	other	JJ
en-wikipedia-org-4107	67	5	potential	potential	JJ
en-wikipedia-org-4107	67	6	physical	physical	JJ
en-wikipedia-org-4107	67	7	side	side	NN
en-wikipedia-org-4107	67	8	effects	effect	NNS
en-wikipedia-org-4107	67	9	include	include	VBP
en-wikipedia-org-4107	67	10	appetite	appetite	JJ
en-wikipedia-org-4107	67	11	loss	loss	NN
en-wikipedia-org-4107	67	12	,	,	,
en-wikipedia-org-4107	67	13	blurred	blurred	JJ
en-wikipedia-org-4107	67	14	vision	vision	NN
en-wikipedia-org-4107	67	15	,	,	,
en-wikipedia-org-4107	67	16	dry	dry	JJ
en-wikipedia-org-4107	67	17	mouth	mouth	NN
en-wikipedia-org-4107	67	18	,	,	,
en-wikipedia-org-4107	67	19	excessive	excessive	JJ
en-wikipedia-org-4107	67	20	grinding	grinding	NN
en-wikipedia-org-4107	67	21	of	of	IN
en-wikipedia-org-4107	67	22	the	the	DT
en-wikipedia-org-4107	67	23	teeth	tooth	NNS
en-wikipedia-org-4107	67	24	,	,	,
en-wikipedia-org-4107	67	25	nosebleed	nosebleed	NNP
en-wikipedia-org-4107	67	26	,	,	,
en-wikipedia-org-4107	67	27	profuse	profuse	NN
en-wikipedia-org-4107	67	28	sweating	sweating	NN
en-wikipedia-org-4107	67	29	,	,	,
en-wikipedia-org-4107	67	30	rhinitis	rhinitis	NNP
en-wikipedia-org-4107	67	31	medicamentosa	medicamentosa	NNP
en-wikipedia-org-4107	67	32	(	(	-LRB-
en-wikipedia-org-4107	67	33	drug	drug	NN
en-wikipedia-org-4107	67	34	-	-	HYPH
en-wikipedia-org-4107	67	35	induced	induce	VBN
en-wikipedia-org-4107	67	36	nasal	nasal	NN
en-wikipedia-org-4107	67	37	congestion	congestion	NN
en-wikipedia-org-4107	67	38	)	)	-RRB-
en-wikipedia-org-4107	67	39	,	,	,
en-wikipedia-org-4107	67	40	reduced	reduce	VBN
en-wikipedia-org-4107	67	41	seizure	seizure	NN
en-wikipedia-org-4107	67	42	threshold	threshold	NN
en-wikipedia-org-4107	67	43	,	,	,
en-wikipedia-org-4107	67	44	tics	tic	NNS
en-wikipedia-org-4107	67	45	(	(	-LRB-
en-wikipedia-org-4107	67	46	a	a	DT
en-wikipedia-org-4107	67	47	type	type	NN
en-wikipedia-org-4107	67	48	of	of	IN
en-wikipedia-org-4107	67	49	movement	movement	NN
en-wikipedia-org-4107	67	50	disorder	disorder	NN
en-wikipedia-org-4107	67	51	)	)	-RRB-
en-wikipedia-org-4107	67	52	,	,	,
en-wikipedia-org-4107	67	53	and	and	CC
en-wikipedia-org-4107	67	54	weight	weight	NN
en-wikipedia-org-4107	67	55	loss	loss	NN
en-wikipedia-org-4107	67	56	.	.	.
en-wikipedia-org-4107	68	1	[	[	-LRB-
en-wikipedia-org-4107	68	2	sources	source	NNS
en-wikipedia-org-4107	68	3	5	5	CD
en-wikipedia-org-4107	68	4	]	]	-RRB-
en-wikipedia-org-4107	68	5	Dangerous	dangerous	JJ
en-wikipedia-org-4107	68	6	physical	physical	JJ
en-wikipedia-org-4107	68	7	side	side	NN
en-wikipedia-org-4107	68	8	effects	effect	NNS
en-wikipedia-org-4107	68	9	are	be	VBP
en-wikipedia-org-4107	68	10	rare	rare	JJ
en-wikipedia-org-4107	68	11	at	at	IN
en-wikipedia-org-4107	68	12	typical	typical	JJ
en-wikipedia-org-4107	68	13	pharmaceutical	pharmaceutical	JJ
en-wikipedia-org-4107	68	14	doses	dose	NNS
en-wikipedia-org-4107	68	15	.	.	.
en-wikipedia-org-4107	69	1	[	[	-LRB-
en-wikipedia-org-4107	69	2	39	39	CD
en-wikipedia-org-4107	69	3	]	]	-RRB-
en-wikipedia-org-4107	69	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	69	5	stimulates	stimulate	VBZ
en-wikipedia-org-4107	69	6	the	the	DT
en-wikipedia-org-4107	69	7	medullary	medullary	JJ
en-wikipedia-org-4107	69	8	respiratory	respiratory	JJ
en-wikipedia-org-4107	69	9	centers	center	NNS
en-wikipedia-org-4107	69	10	,	,	,
en-wikipedia-org-4107	69	11	producing	produce	VBG
en-wikipedia-org-4107	69	12	faster	fast	RBR
en-wikipedia-org-4107	69	13	and	and	CC
en-wikipedia-org-4107	69	14	deeper	deep	JJR
en-wikipedia-org-4107	69	15	breaths	breath	NNS
en-wikipedia-org-4107	69	16	.	.	.
en-wikipedia-org-4107	70	1	[	[	-LRB-
en-wikipedia-org-4107	70	2	39	39	CD
en-wikipedia-org-4107	70	3	]	]	-RRB-
en-wikipedia-org-4107	70	4	In	in	IN
en-wikipedia-org-4107	70	5	a	a	DT
en-wikipedia-org-4107	70	6	normal	normal	JJ
en-wikipedia-org-4107	70	7	person	person	NN
en-wikipedia-org-4107	70	8	at	at	IN
en-wikipedia-org-4107	70	9	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	70	10	doses	dose	NNS
en-wikipedia-org-4107	70	11	,	,	,
en-wikipedia-org-4107	70	12	this	this	DT
en-wikipedia-org-4107	70	13	effect	effect	NN
en-wikipedia-org-4107	70	14	is	be	VBZ
en-wikipedia-org-4107	70	15	usually	usually	RB
en-wikipedia-org-4107	70	16	not	not	RB
en-wikipedia-org-4107	70	17	noticeable	noticeable	JJ
en-wikipedia-org-4107	70	18	,	,	,
en-wikipedia-org-4107	70	19	but	but	CC
en-wikipedia-org-4107	70	20	when	when	WRB
en-wikipedia-org-4107	70	21	respiration	respiration	NN
en-wikipedia-org-4107	70	22	is	be	VBZ
en-wikipedia-org-4107	70	23	already	already	RB
en-wikipedia-org-4107	70	24	compromised	compromise	VBN
en-wikipedia-org-4107	70	25	,	,	,
en-wikipedia-org-4107	70	26	it	-PRON-	PRP
en-wikipedia-org-4107	70	27	may	may	MD
en-wikipedia-org-4107	70	28	be	be	VB
en-wikipedia-org-4107	70	29	evident	evident	JJ
en-wikipedia-org-4107	70	30	.	.	.
en-wikipedia-org-4107	71	1	[	[	-LRB-
en-wikipedia-org-4107	71	2	39	39	CD
en-wikipedia-org-4107	71	3	]	]	-RRB-
en-wikipedia-org-4107	71	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	71	5	also	also	RB
en-wikipedia-org-4107	71	6	induces	induce	VBZ
en-wikipedia-org-4107	71	7	contraction	contraction	NN
en-wikipedia-org-4107	71	8	in	in	IN
en-wikipedia-org-4107	71	9	the	the	DT
en-wikipedia-org-4107	71	10	urinary	urinary	JJ
en-wikipedia-org-4107	71	11	bladder	bladder	NN
en-wikipedia-org-4107	71	12	sphincter	sphincter	NN
en-wikipedia-org-4107	71	13	,	,	,
en-wikipedia-org-4107	71	14	the	the	DT
en-wikipedia-org-4107	71	15	muscle	muscle	NN
en-wikipedia-org-4107	71	16	which	which	WDT
en-wikipedia-org-4107	71	17	controls	control	VBZ
en-wikipedia-org-4107	71	18	urination	urination	NN
en-wikipedia-org-4107	71	19	,	,	,
en-wikipedia-org-4107	71	20	which	which	WDT
en-wikipedia-org-4107	71	21	can	can	MD
en-wikipedia-org-4107	71	22	result	result	VB
en-wikipedia-org-4107	71	23	in	in	IN
en-wikipedia-org-4107	71	24	difficulty	difficulty	NN
en-wikipedia-org-4107	71	25	urinating	urinate	VBG
en-wikipedia-org-4107	71	26	.	.	.
en-wikipedia-org-4107	72	1	[	[	-LRB-
en-wikipedia-org-4107	72	2	39	39	CD
en-wikipedia-org-4107	72	3	]	]	-RRB-
en-wikipedia-org-4107	72	4	This	this	DT
en-wikipedia-org-4107	72	5	effect	effect	NN
en-wikipedia-org-4107	72	6	can	can	MD
en-wikipedia-org-4107	72	7	be	be	VB
en-wikipedia-org-4107	72	8	useful	useful	JJ
en-wikipedia-org-4107	72	9	in	in	IN
en-wikipedia-org-4107	72	10	treating	treat	VBG
en-wikipedia-org-4107	72	11	bed	bed	NN
en-wikipedia-org-4107	72	12	wetting	wetting	NN
en-wikipedia-org-4107	72	13	and	and	CC
en-wikipedia-org-4107	72	14	loss	loss	NN
en-wikipedia-org-4107	72	15	of	of	IN
en-wikipedia-org-4107	72	16	bladder	bladder	NN
en-wikipedia-org-4107	72	17	control	control	NN
en-wikipedia-org-4107	72	18	.	.	.
en-wikipedia-org-4107	73	1	[	[	-LRB-
en-wikipedia-org-4107	73	2	39	39	CD
en-wikipedia-org-4107	73	3	]	]	-RRB-
en-wikipedia-org-4107	73	4	The	the	DT
en-wikipedia-org-4107	73	5	effects	effect	NNS
en-wikipedia-org-4107	73	6	of	of	IN
en-wikipedia-org-4107	73	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	73	8	on	on	IN
en-wikipedia-org-4107	73	9	the	the	DT
en-wikipedia-org-4107	73	10	gastrointestinal	gastrointestinal	JJ
en-wikipedia-org-4107	73	11	tract	tract	NN
en-wikipedia-org-4107	73	12	are	be	VBP
en-wikipedia-org-4107	73	13	unpredictable	unpredictable	JJ
en-wikipedia-org-4107	73	14	.	.	.
en-wikipedia-org-4107	74	1	[	[	-LRB-
en-wikipedia-org-4107	74	2	39	39	CD
en-wikipedia-org-4107	74	3	]	]	-RRB-
en-wikipedia-org-4107	74	4	If	if	IN
en-wikipedia-org-4107	74	5	intestinal	intestinal	JJ
en-wikipedia-org-4107	74	6	activity	activity	NN
en-wikipedia-org-4107	74	7	is	be	VBZ
en-wikipedia-org-4107	74	8	high	high	JJ
en-wikipedia-org-4107	74	9	,	,	,
en-wikipedia-org-4107	74	10	amphetamine	amphetamine	NN
en-wikipedia-org-4107	74	11	may	may	MD
en-wikipedia-org-4107	74	12	reduce	reduce	VB
en-wikipedia-org-4107	74	13	gastrointestinal	gastrointestinal	JJ
en-wikipedia-org-4107	74	14	motility	motility	NN
en-wikipedia-org-4107	74	15	(	(	-LRB-
en-wikipedia-org-4107	74	16	the	the	DT
en-wikipedia-org-4107	74	17	rate	rate	NN
en-wikipedia-org-4107	74	18	at	at	IN
en-wikipedia-org-4107	74	19	which	which	WDT
en-wikipedia-org-4107	74	20	content	content	NN
en-wikipedia-org-4107	74	21	moves	move	NNS
en-wikipedia-org-4107	74	22	through	through	IN
en-wikipedia-org-4107	74	23	the	the	DT
en-wikipedia-org-4107	74	24	digestive	digestive	NNP
en-wikipedia-org-4107	74	25	system);[39	system);[39	.
en-wikipedia-org-4107	74	26	]	]	-RRB-
en-wikipedia-org-4107	74	27	however	however	RB
en-wikipedia-org-4107	74	28	,	,	,
en-wikipedia-org-4107	74	29	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	74	30	may	may	MD
en-wikipedia-org-4107	74	31	increase	increase	VB
en-wikipedia-org-4107	74	32	motility	motility	NN
en-wikipedia-org-4107	74	33	when	when	WRB
en-wikipedia-org-4107	74	34	the	the	DT
en-wikipedia-org-4107	74	35	smooth	smooth	JJ
en-wikipedia-org-4107	74	36	muscle	muscle	NN
en-wikipedia-org-4107	74	37	of	of	IN
en-wikipedia-org-4107	74	38	the	the	DT
en-wikipedia-org-4107	74	39	tract	tract	NN
en-wikipedia-org-4107	74	40	is	be	VBZ
en-wikipedia-org-4107	74	41	relaxed	relaxed	JJ
en-wikipedia-org-4107	74	42	.	.	.
en-wikipedia-org-4107	75	1	[	[	-LRB-
en-wikipedia-org-4107	75	2	39	39	CD
en-wikipedia-org-4107	75	3	]	]	-RRB-
en-wikipedia-org-4107	75	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	75	5	also	also	RB
en-wikipedia-org-4107	75	6	has	have	VBZ
en-wikipedia-org-4107	75	7	a	a	DT
en-wikipedia-org-4107	75	8	slight	slight	JJ
en-wikipedia-org-4107	75	9	analgesic	analgesic	JJ
en-wikipedia-org-4107	75	10	effect	effect	NN
en-wikipedia-org-4107	75	11	and	and	CC
en-wikipedia-org-4107	75	12	can	can	MD
en-wikipedia-org-4107	75	13	enhance	enhance	VB
en-wikipedia-org-4107	75	14	the	the	DT
en-wikipedia-org-4107	75	15	pain	pain	NN
en-wikipedia-org-4107	75	16	relieving	relieving	NN
en-wikipedia-org-4107	75	17	effects	effect	NNS
en-wikipedia-org-4107	75	18	of	of	IN
en-wikipedia-org-4107	75	19	opioids	opioid	NNS
en-wikipedia-org-4107	75	20	.	.	.
en-wikipedia-org-4107	76	1	[	[	-LRB-
en-wikipedia-org-4107	76	2	2][39	2][39	LS
en-wikipedia-org-4107	76	3	]	]	-RRB-
en-wikipedia-org-4107	76	4	USFDA	USFDA	NNP
en-wikipedia-org-4107	76	5	-	-	HYPH
en-wikipedia-org-4107	76	6	commissioned	commission	VBN
en-wikipedia-org-4107	76	7	studies	study	NNS
en-wikipedia-org-4107	76	8	from	from	IN
en-wikipedia-org-4107	76	9	2011	2011	CD
en-wikipedia-org-4107	76	10	indicate	indicate	VBP
en-wikipedia-org-4107	76	11	that	that	IN
en-wikipedia-org-4107	76	12	in	in	IN
en-wikipedia-org-4107	76	13	children	child	NNS
en-wikipedia-org-4107	76	14	,	,	,
en-wikipedia-org-4107	76	15	young	young	JJ
en-wikipedia-org-4107	76	16	adults	adult	NNS
en-wikipedia-org-4107	76	17	,	,	,
en-wikipedia-org-4107	76	18	and	and	CC
en-wikipedia-org-4107	76	19	adults	adult	NNS
en-wikipedia-org-4107	76	20	there	there	EX
en-wikipedia-org-4107	76	21	is	be	VBZ
en-wikipedia-org-4107	76	22	no	no	DT
en-wikipedia-org-4107	76	23	association	association	NN
en-wikipedia-org-4107	76	24	between	between	IN
en-wikipedia-org-4107	76	25	serious	serious	JJ
en-wikipedia-org-4107	76	26	adverse	adverse	JJ
en-wikipedia-org-4107	76	27	cardiovascular	cardiovascular	JJ
en-wikipedia-org-4107	76	28	events	event	NNS
en-wikipedia-org-4107	76	29	(	(	-LRB-
en-wikipedia-org-4107	76	30	sudden	sudden	JJ
en-wikipedia-org-4107	76	31	death	death	NN
en-wikipedia-org-4107	76	32	,	,	,
en-wikipedia-org-4107	76	33	heart	heart	NN
en-wikipedia-org-4107	76	34	attack	attack	NN
en-wikipedia-org-4107	76	35	,	,	,
en-wikipedia-org-4107	76	36	and	and	CC
en-wikipedia-org-4107	76	37	stroke	stroke	NN
en-wikipedia-org-4107	76	38	)	)	-RRB-
en-wikipedia-org-4107	76	39	and	and	CC
en-wikipedia-org-4107	76	40	the	the	DT
en-wikipedia-org-4107	76	41	medical	medical	JJ
en-wikipedia-org-4107	76	42	use	use	NN
en-wikipedia-org-4107	76	43	of	of	IN
en-wikipedia-org-4107	76	44	amphetamine	amphetamine	NN
en-wikipedia-org-4107	76	45	or	or	CC
en-wikipedia-org-4107	76	46	other	other	JJ
en-wikipedia-org-4107	76	47	ADHD	ADHD	NNP
en-wikipedia-org-4107	76	48	stimulants	stimulant	NNS
en-wikipedia-org-4107	76	49	.	.	.
en-wikipedia-org-4107	77	1	[	[	-LRB-
en-wikipedia-org-4107	77	2	sources	source	NNS
en-wikipedia-org-4107	77	3	6	6	CD
en-wikipedia-org-4107	77	4	]	]	-RRB-
en-wikipedia-org-4107	77	5	However	however	RB
en-wikipedia-org-4107	77	6	,	,	,
en-wikipedia-org-4107	77	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	77	8	pharmaceuticals	pharmaceutical	NNS
en-wikipedia-org-4107	77	9	are	be	VBP
en-wikipedia-org-4107	77	10	contraindicated	contraindicate	VBN
en-wikipedia-org-4107	77	11	in	in	IN
en-wikipedia-org-4107	77	12	individuals	individual	NNS
en-wikipedia-org-4107	77	13	with	with	IN
en-wikipedia-org-4107	77	14	cardiovascular	cardiovascular	JJ
en-wikipedia-org-4107	77	15	disease	disease	NN
en-wikipedia-org-4107	77	16	.	.	.
en-wikipedia-org-4107	78	1	[	[	-LRB-
en-wikipedia-org-4107	78	2	sources	source	NNS
en-wikipedia-org-4107	78	3	7	7	CD
en-wikipedia-org-4107	78	4	]	]	-RRB-
en-wikipedia-org-4107	78	5	Psychological	Psychological	NNP
en-wikipedia-org-4107	78	6	At	at	IN
en-wikipedia-org-4107	78	7	normal	normal	JJ
en-wikipedia-org-4107	78	8	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	78	9	doses	dose	NNS
en-wikipedia-org-4107	78	10	,	,	,
en-wikipedia-org-4107	78	11	the	the	DT
en-wikipedia-org-4107	78	12	most	most	RBS
en-wikipedia-org-4107	78	13	common	common	JJ
en-wikipedia-org-4107	78	14	psychological	psychological	JJ
en-wikipedia-org-4107	78	15	side	side	NN
en-wikipedia-org-4107	78	16	effects	effect	NNS
en-wikipedia-org-4107	78	17	of	of	IN
en-wikipedia-org-4107	78	18	amphetamine	amphetamine	NN
en-wikipedia-org-4107	78	19	include	include	VBP
en-wikipedia-org-4107	78	20	increased	increase	VBN
en-wikipedia-org-4107	78	21	alertness	alertness	NN
en-wikipedia-org-4107	78	22	,	,	,
en-wikipedia-org-4107	78	23	apprehension	apprehension	NN
en-wikipedia-org-4107	78	24	,	,	,
en-wikipedia-org-4107	78	25	concentration	concentration	NN
en-wikipedia-org-4107	78	26	,	,	,
en-wikipedia-org-4107	78	27	initiative	initiative	NN
en-wikipedia-org-4107	78	28	,	,	,
en-wikipedia-org-4107	78	29	self	self	NN
en-wikipedia-org-4107	78	30	-	-	HYPH
en-wikipedia-org-4107	78	31	confidence	confidence	NN
en-wikipedia-org-4107	78	32	and	and	CC
en-wikipedia-org-4107	78	33	sociability	sociability	NN
en-wikipedia-org-4107	78	34	,	,	,
en-wikipedia-org-4107	78	35	mood	mood	NN
en-wikipedia-org-4107	78	36	swings	swing	NNS
en-wikipedia-org-4107	78	37	(	(	-LRB-
en-wikipedia-org-4107	78	38	elated	elated	JJ
en-wikipedia-org-4107	78	39	mood	mood	NN
en-wikipedia-org-4107	78	40	followed	follow	VBN
en-wikipedia-org-4107	78	41	by	by	IN
en-wikipedia-org-4107	78	42	mildly	mildly	RB
en-wikipedia-org-4107	78	43	depressed	depressed	JJ
en-wikipedia-org-4107	78	44	mood	mood	NN
en-wikipedia-org-4107	78	45	)	)	-RRB-
en-wikipedia-org-4107	78	46	,	,	,
en-wikipedia-org-4107	78	47	insomnia	insomnia	NN
en-wikipedia-org-4107	78	48	or	or	CC
en-wikipedia-org-4107	78	49	wakefulness	wakefulness	NN
en-wikipedia-org-4107	78	50	,	,	,
en-wikipedia-org-4107	78	51	and	and	CC
en-wikipedia-org-4107	78	52	decreased	decrease	VBD
en-wikipedia-org-4107	78	53	sense	sense	NN
en-wikipedia-org-4107	78	54	of	of	IN
en-wikipedia-org-4107	78	55	fatigue	fatigue	NN
en-wikipedia-org-4107	78	56	.	.	.
en-wikipedia-org-4107	79	1	[	[	-LRB-
en-wikipedia-org-4107	79	2	28][39	28][39	LS
en-wikipedia-org-4107	79	3	]	]	-RRB-
en-wikipedia-org-4107	79	4	Less	less	RBR
en-wikipedia-org-4107	79	5	common	common	JJ
en-wikipedia-org-4107	79	6	side	side	NN
en-wikipedia-org-4107	79	7	effects	effect	NNS
en-wikipedia-org-4107	79	8	include	include	VBP
en-wikipedia-org-4107	79	9	anxiety	anxiety	NN
en-wikipedia-org-4107	79	10	,	,	,
en-wikipedia-org-4107	79	11	change	change	NN
en-wikipedia-org-4107	79	12	in	in	IN
en-wikipedia-org-4107	79	13	libido	libido	NN
en-wikipedia-org-4107	79	14	,	,	,
en-wikipedia-org-4107	79	15	grandiosity	grandiosity	NN
en-wikipedia-org-4107	79	16	,	,	,
en-wikipedia-org-4107	79	17	irritability	irritability	NN
en-wikipedia-org-4107	79	18	,	,	,
en-wikipedia-org-4107	79	19	repetitive	repetitive	JJ
en-wikipedia-org-4107	79	20	or	or	CC
en-wikipedia-org-4107	79	21	obsessive	obsessive	JJ
en-wikipedia-org-4107	79	22	behaviors	behavior	NNS
en-wikipedia-org-4107	79	23	,	,	,
en-wikipedia-org-4107	79	24	and	and	CC
en-wikipedia-org-4107	79	25	restlessness;[sources	restlessness;[source	VBZ
en-wikipedia-org-4107	79	26	8	8	LS
en-wikipedia-org-4107	79	27	]	]	-RRB-
en-wikipedia-org-4107	79	28	these	these	DT
en-wikipedia-org-4107	79	29	effects	effect	NNS
en-wikipedia-org-4107	79	30	depend	depend	VBP
en-wikipedia-org-4107	79	31	on	on	IN
en-wikipedia-org-4107	79	32	the	the	DT
en-wikipedia-org-4107	79	33	user	user	NN
en-wikipedia-org-4107	79	34	's	's	POS
en-wikipedia-org-4107	79	35	personality	personality	NN
en-wikipedia-org-4107	79	36	and	and	CC
en-wikipedia-org-4107	79	37	current	current	JJ
en-wikipedia-org-4107	79	38	mental	mental	JJ
en-wikipedia-org-4107	79	39	state	state	NN
en-wikipedia-org-4107	79	40	.	.	.
en-wikipedia-org-4107	80	1	[	[	-LRB-
en-wikipedia-org-4107	80	2	39	39	CD
en-wikipedia-org-4107	80	3	]	]	-RRB-
en-wikipedia-org-4107	80	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	80	5	psychosis	psychosis	NN
en-wikipedia-org-4107	80	6	(	(	-LRB-
en-wikipedia-org-4107	80	7	e.g.	e.g.	RB
en-wikipedia-org-4107	80	8	,	,	,
en-wikipedia-org-4107	80	9	delusions	delusion	NNS
en-wikipedia-org-4107	80	10	and	and	CC
en-wikipedia-org-4107	80	11	paranoia	paranoia	NN
en-wikipedia-org-4107	80	12	)	)	-RRB-
en-wikipedia-org-4107	80	13	can	can	MD
en-wikipedia-org-4107	80	14	occur	occur	VB
en-wikipedia-org-4107	80	15	in	in	IN
en-wikipedia-org-4107	80	16	heavy	heavy	JJ
en-wikipedia-org-4107	80	17	users	user	NNS
en-wikipedia-org-4107	80	18	.	.	.
en-wikipedia-org-4107	81	1	[	[	-LRB-
en-wikipedia-org-4107	81	2	28][40][41	28][40][41	CD
en-wikipedia-org-4107	81	3	]	]	-RRB-
en-wikipedia-org-4107	81	4	Although	although	IN
en-wikipedia-org-4107	81	5	very	very	RB
en-wikipedia-org-4107	81	6	rare	rare	JJ
en-wikipedia-org-4107	81	7	,	,	,
en-wikipedia-org-4107	81	8	this	this	DT
en-wikipedia-org-4107	81	9	psychosis	psychosis	NN
en-wikipedia-org-4107	81	10	can	can	MD
en-wikipedia-org-4107	81	11	also	also	RB
en-wikipedia-org-4107	81	12	occur	occur	VB
en-wikipedia-org-4107	81	13	at	at	IN
en-wikipedia-org-4107	81	14	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	81	15	doses	dose	NNS
en-wikipedia-org-4107	81	16	during	during	IN
en-wikipedia-org-4107	81	17	long	long	JJ
en-wikipedia-org-4107	81	18	-	-	HYPH
en-wikipedia-org-4107	81	19	term	term	NN
en-wikipedia-org-4107	81	20	therapy	therapy	NN
en-wikipedia-org-4107	81	21	.	.	.
en-wikipedia-org-4107	82	1	[	[	-LRB-
en-wikipedia-org-4107	82	2	28][41][42	28][41][42	CD
en-wikipedia-org-4107	82	3	]	]	-RRB-
en-wikipedia-org-4107	82	4	According	accord	VBG
en-wikipedia-org-4107	82	5	to	to	IN
en-wikipedia-org-4107	82	6	the	the	DT
en-wikipedia-org-4107	82	7	USFDA	USFDA	NNP
en-wikipedia-org-4107	82	8	,	,	,
en-wikipedia-org-4107	82	9	"	"	``
en-wikipedia-org-4107	82	10	there	there	EX
en-wikipedia-org-4107	82	11	is	be	VBZ
en-wikipedia-org-4107	82	12	no	no	DT
en-wikipedia-org-4107	82	13	systematic	systematic	JJ
en-wikipedia-org-4107	82	14	evidence	evidence	NN
en-wikipedia-org-4107	82	15	"	"	''
en-wikipedia-org-4107	82	16	that	that	WDT
en-wikipedia-org-4107	82	17	stimulants	stimulant	NNS
en-wikipedia-org-4107	82	18	produce	produce	VBP
en-wikipedia-org-4107	82	19	aggressive	aggressive	JJ
en-wikipedia-org-4107	82	20	behavior	behavior	NN
en-wikipedia-org-4107	82	21	or	or	CC
en-wikipedia-org-4107	82	22	hostility	hostility	NN
en-wikipedia-org-4107	82	23	.	.	.
en-wikipedia-org-4107	83	1	[	[	-LRB-
en-wikipedia-org-4107	83	2	28	28	CD
en-wikipedia-org-4107	83	3	]	]	-RRB-
en-wikipedia-org-4107	83	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	83	5	has	have	VBZ
en-wikipedia-org-4107	83	6	also	also	RB
en-wikipedia-org-4107	83	7	been	be	VBN
en-wikipedia-org-4107	83	8	shown	show	VBN
en-wikipedia-org-4107	83	9	to	to	TO
en-wikipedia-org-4107	83	10	produce	produce	VB
en-wikipedia-org-4107	83	11	a	a	DT
en-wikipedia-org-4107	83	12	conditioned	condition	VBN
en-wikipedia-org-4107	83	13	place	place	NN
en-wikipedia-org-4107	83	14	preference	preference	NN
en-wikipedia-org-4107	83	15	in	in	IN
en-wikipedia-org-4107	83	16	humans	human	NNS
en-wikipedia-org-4107	83	17	taking	take	VBG
en-wikipedia-org-4107	83	18	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	83	19	doses,[63][95	doses,[63][95	POS
en-wikipedia-org-4107	83	20	]	]	-RRB-
en-wikipedia-org-4107	83	21	meaning	meaning	NN
en-wikipedia-org-4107	83	22	that	that	IN
en-wikipedia-org-4107	83	23	individuals	individual	NNS
en-wikipedia-org-4107	83	24	acquire	acquire	VBP
en-wikipedia-org-4107	83	25	a	a	DT
en-wikipedia-org-4107	83	26	preference	preference	NN
en-wikipedia-org-4107	83	27	for	for	IN
en-wikipedia-org-4107	83	28	spending	spend	VBG
en-wikipedia-org-4107	83	29	time	time	NN
en-wikipedia-org-4107	83	30	in	in	IN
en-wikipedia-org-4107	83	31	places	place	NNS
en-wikipedia-org-4107	83	32	where	where	WRB
en-wikipedia-org-4107	83	33	they	-PRON-	PRP
en-wikipedia-org-4107	83	34	have	have	VBP
en-wikipedia-org-4107	83	35	previously	previously	RB
en-wikipedia-org-4107	83	36	used	use	VBN
en-wikipedia-org-4107	83	37	amphetamine	amphetamine	NN
en-wikipedia-org-4107	83	38	.	.	.
en-wikipedia-org-4107	84	1	[	[	-LRB-
en-wikipedia-org-4107	84	2	95][96	95][96	CD
en-wikipedia-org-4107	84	3	]	]	-RRB-
en-wikipedia-org-4107	84	4	Reinforcement	reinforcement	NN
en-wikipedia-org-4107	84	5	disorders	disorder	VBZ
en-wikipedia-org-4107	84	6	Addiction	addiction	NN
en-wikipedia-org-4107	84	7	Addiction	addiction	NN
en-wikipedia-org-4107	84	8	and	and	CC
en-wikipedia-org-4107	84	9	dependence	dependence	NN
en-wikipedia-org-4107	84	10	glossary[96][97][98][99	glossary[96][97][98][99	NNP
en-wikipedia-org-4107	84	11	]	]	-RRB-
en-wikipedia-org-4107	84	12	addiction	addiction	NN
en-wikipedia-org-4107	84	13	–	–	:
en-wikipedia-org-4107	84	14	a	a	DT
en-wikipedia-org-4107	84	15	biopsychosocial	biopsychosocial	JJ
en-wikipedia-org-4107	84	16	disorder	disorder	NN
en-wikipedia-org-4107	84	17	characterized	characterize	VBN
en-wikipedia-org-4107	84	18	by	by	IN
en-wikipedia-org-4107	84	19	persistent	persistent	JJ
en-wikipedia-org-4107	84	20	use	use	NN
en-wikipedia-org-4107	84	21	of	of	IN
en-wikipedia-org-4107	84	22	drugs	drug	NNS
en-wikipedia-org-4107	84	23	(	(	-LRB-
en-wikipedia-org-4107	84	24	including	include	VBG
en-wikipedia-org-4107	84	25	alcohol	alcohol	NN
en-wikipedia-org-4107	84	26	)	)	-RRB-
en-wikipedia-org-4107	84	27	despite	despite	IN
en-wikipedia-org-4107	84	28	substantial	substantial	JJ
en-wikipedia-org-4107	84	29	harm	harm	NN
en-wikipedia-org-4107	84	30	and	and	CC
en-wikipedia-org-4107	84	31	adverse	adverse	JJ
en-wikipedia-org-4107	84	32	consequences	consequence	NNS
en-wikipedia-org-4107	84	33	addictive	addictive	JJ
en-wikipedia-org-4107	84	34	behavior	behavior	NN
en-wikipedia-org-4107	84	35	–	–	:
en-wikipedia-org-4107	84	36	a	a	DT
en-wikipedia-org-4107	84	37	behavior	behavior	NN
en-wikipedia-org-4107	84	38	that	that	WDT
en-wikipedia-org-4107	84	39	is	be	VBZ
en-wikipedia-org-4107	84	40	both	both	DT
en-wikipedia-org-4107	84	41	rewarding	rewarding	JJ
en-wikipedia-org-4107	84	42	and	and	CC
en-wikipedia-org-4107	84	43	reinforcing	reinforce	VBG
en-wikipedia-org-4107	84	44	addictive	addictive	JJ
en-wikipedia-org-4107	84	45	drug	drug	NN
en-wikipedia-org-4107	84	46	–	–	:
en-wikipedia-org-4107	84	47	a	a	DT
en-wikipedia-org-4107	84	48	drug	drug	NN
en-wikipedia-org-4107	84	49	that	that	WDT
en-wikipedia-org-4107	84	50	is	be	VBZ
en-wikipedia-org-4107	84	51	both	both	DT
en-wikipedia-org-4107	84	52	rewarding	rewarding	JJ
en-wikipedia-org-4107	84	53	and	and	CC
en-wikipedia-org-4107	84	54	reinforcing	reinforce	VBG
en-wikipedia-org-4107	84	55	dependence	dependence	NN
en-wikipedia-org-4107	84	56	–	–	:
en-wikipedia-org-4107	84	57	an	an	DT
en-wikipedia-org-4107	84	58	adaptive	adaptive	JJ
en-wikipedia-org-4107	84	59	state	state	NN
en-wikipedia-org-4107	84	60	associated	associate	VBN
en-wikipedia-org-4107	84	61	with	with	IN
en-wikipedia-org-4107	84	62	a	a	DT
en-wikipedia-org-4107	84	63	withdrawal	withdrawal	NN
en-wikipedia-org-4107	84	64	syndrome	syndrome	NN
en-wikipedia-org-4107	84	65	upon	upon	IN
en-wikipedia-org-4107	84	66	cessation	cessation	NN
en-wikipedia-org-4107	84	67	of	of	IN
en-wikipedia-org-4107	84	68	repeated	repeat	VBN
en-wikipedia-org-4107	84	69	exposure	exposure	NN
en-wikipedia-org-4107	84	70	to	to	IN
en-wikipedia-org-4107	84	71	a	a	DT
en-wikipedia-org-4107	84	72	stimulus	stimulus	NN
en-wikipedia-org-4107	84	73	(	(	-LRB-
en-wikipedia-org-4107	84	74	e.g.	e.g.	RB
en-wikipedia-org-4107	84	75	,	,	,
en-wikipedia-org-4107	84	76	drug	drug	NN
en-wikipedia-org-4107	84	77	intake	intake	NN
en-wikipedia-org-4107	84	78	)	)	-RRB-
en-wikipedia-org-4107	84	79	drug	drug	NN
en-wikipedia-org-4107	84	80	sensitization	sensitization	NN
en-wikipedia-org-4107	84	81	or	or	CC
en-wikipedia-org-4107	84	82	reverse	reverse	VB
en-wikipedia-org-4107	84	83	tolerance	tolerance	NN
en-wikipedia-org-4107	84	84	–	–	:
en-wikipedia-org-4107	84	85	the	the	DT
en-wikipedia-org-4107	84	86	escalating	escalate	VBG
en-wikipedia-org-4107	84	87	effect	effect	NN
en-wikipedia-org-4107	84	88	of	of	IN
en-wikipedia-org-4107	84	89	a	a	DT
en-wikipedia-org-4107	84	90	drug	drug	NN
en-wikipedia-org-4107	84	91	resulting	result	VBG
en-wikipedia-org-4107	84	92	from	from	IN
en-wikipedia-org-4107	84	93	repeated	repeat	VBN
en-wikipedia-org-4107	84	94	administration	administration	NN
en-wikipedia-org-4107	84	95	at	at	IN
en-wikipedia-org-4107	84	96	a	a	DT
en-wikipedia-org-4107	84	97	given	give	VBN
en-wikipedia-org-4107	84	98	dose	dose	NN
en-wikipedia-org-4107	84	99	drug	drug	NN
en-wikipedia-org-4107	84	100	withdrawal	withdrawal	NN
en-wikipedia-org-4107	84	101	–	–	:
en-wikipedia-org-4107	84	102	symptoms	symptom	NNS
en-wikipedia-org-4107	84	103	that	that	WDT
en-wikipedia-org-4107	84	104	occur	occur	VBP
en-wikipedia-org-4107	84	105	upon	upon	IN
en-wikipedia-org-4107	84	106	cessation	cessation	NN
en-wikipedia-org-4107	84	107	of	of	IN
en-wikipedia-org-4107	84	108	repeated	repeat	VBN
en-wikipedia-org-4107	84	109	drug	drug	NN
en-wikipedia-org-4107	84	110	use	use	NN
en-wikipedia-org-4107	84	111	physical	physical	JJ
en-wikipedia-org-4107	84	112	dependence	dependence	NN
en-wikipedia-org-4107	84	113	–	–	:
en-wikipedia-org-4107	84	114	dependence	dependence	NN
en-wikipedia-org-4107	84	115	that	that	WDT
en-wikipedia-org-4107	84	116	involves	involve	VBZ
en-wikipedia-org-4107	84	117	persistent	persistent	JJ
en-wikipedia-org-4107	84	118	physical	physical	JJ
en-wikipedia-org-4107	84	119	–	–	:
en-wikipedia-org-4107	84	120	somatic	somatic	JJ
en-wikipedia-org-4107	84	121	withdrawal	withdrawal	NN
en-wikipedia-org-4107	84	122	symptoms	symptom	NNS
en-wikipedia-org-4107	84	123	(	(	-LRB-
en-wikipedia-org-4107	84	124	e.g.	e.g.	RB
en-wikipedia-org-4107	84	125	,	,	,
en-wikipedia-org-4107	84	126	fatigue	fatigue	NN
en-wikipedia-org-4107	84	127	and	and	CC
en-wikipedia-org-4107	84	128	delirium	delirium	NN
en-wikipedia-org-4107	84	129	tremens	tremen	NNS
en-wikipedia-org-4107	84	130	)	)	-RRB-
en-wikipedia-org-4107	84	131	psychological	psychological	JJ
en-wikipedia-org-4107	84	132	dependence	dependence	NN
en-wikipedia-org-4107	84	133	–	–	:
en-wikipedia-org-4107	84	134	dependence	dependence	NN
en-wikipedia-org-4107	84	135	that	that	WDT
en-wikipedia-org-4107	84	136	involves	involve	VBZ
en-wikipedia-org-4107	84	137	emotional	emotional	JJ
en-wikipedia-org-4107	84	138	–	–	:
en-wikipedia-org-4107	84	139	motivational	motivational	JJ
en-wikipedia-org-4107	84	140	withdrawal	withdrawal	NN
en-wikipedia-org-4107	84	141	symptoms	symptom	NNS
en-wikipedia-org-4107	84	142	(	(	-LRB-
en-wikipedia-org-4107	84	143	e.g.	e.g.	NNP
en-wikipedia-org-4107	84	144	,	,	,
en-wikipedia-org-4107	84	145	dysphoria	dysphoria	NNP
en-wikipedia-org-4107	84	146	and	and	CC
en-wikipedia-org-4107	84	147	anhedonia	anhedonia	NNP
en-wikipedia-org-4107	84	148	)	)	-RRB-
en-wikipedia-org-4107	84	149	reinforcing	reinforce	VBG
en-wikipedia-org-4107	84	150	stimuli	stimulus	NNS
en-wikipedia-org-4107	84	151	–	–	:
en-wikipedia-org-4107	84	152	stimuli	stimulus	NNS
en-wikipedia-org-4107	84	153	that	that	WDT
en-wikipedia-org-4107	84	154	increase	increase	VBP
en-wikipedia-org-4107	84	155	the	the	DT
en-wikipedia-org-4107	84	156	probability	probability	NN
en-wikipedia-org-4107	84	157	of	of	IN
en-wikipedia-org-4107	84	158	repeating	repeat	VBG
en-wikipedia-org-4107	84	159	behaviors	behavior	NNS
en-wikipedia-org-4107	84	160	paired	pair	VBN
en-wikipedia-org-4107	84	161	with	with	IN
en-wikipedia-org-4107	84	162	them	-PRON-	PRP
en-wikipedia-org-4107	84	163	rewarding	rewarding	JJ
en-wikipedia-org-4107	84	164	stimuli	stimulus	NNS
en-wikipedia-org-4107	84	165	–	–	:
en-wikipedia-org-4107	84	166	stimuli	stimulus	NNS
en-wikipedia-org-4107	84	167	that	that	WDT
en-wikipedia-org-4107	84	168	the	the	DT
en-wikipedia-org-4107	84	169	brain	brain	NN
en-wikipedia-org-4107	84	170	interprets	interpret	VBZ
en-wikipedia-org-4107	84	171	as	as	RB
en-wikipedia-org-4107	84	172	intrinsically	intrinsically	RB
en-wikipedia-org-4107	84	173	positive	positive	JJ
en-wikipedia-org-4107	84	174	and	and	CC
en-wikipedia-org-4107	84	175	desirable	desirable	JJ
en-wikipedia-org-4107	84	176	or	or	CC
en-wikipedia-org-4107	84	177	as	as	IN
en-wikipedia-org-4107	84	178	something	something	NN
en-wikipedia-org-4107	84	179	to	to	TO
en-wikipedia-org-4107	84	180	approach	approach	VB
en-wikipedia-org-4107	84	181	sensitization	sensitization	NN
en-wikipedia-org-4107	84	182	–	–	:
en-wikipedia-org-4107	84	183	an	an	DT
en-wikipedia-org-4107	84	184	amplified	amplified	JJ
en-wikipedia-org-4107	84	185	response	response	NN
en-wikipedia-org-4107	84	186	to	to	IN
en-wikipedia-org-4107	84	187	a	a	DT
en-wikipedia-org-4107	84	188	stimulus	stimulus	NN
en-wikipedia-org-4107	84	189	resulting	result	VBG
en-wikipedia-org-4107	84	190	from	from	IN
en-wikipedia-org-4107	84	191	repeated	repeat	VBN
en-wikipedia-org-4107	84	192	exposure	exposure	NN
en-wikipedia-org-4107	84	193	to	to	IN
en-wikipedia-org-4107	84	194	it	-PRON-	PRP
en-wikipedia-org-4107	84	195	substance	substance	VB
en-wikipedia-org-4107	84	196	use	use	NN
en-wikipedia-org-4107	84	197	disorder	disorder	NN
en-wikipedia-org-4107	84	198	–	–	:
en-wikipedia-org-4107	84	199	a	a	DT
en-wikipedia-org-4107	84	200	condition	condition	NN
en-wikipedia-org-4107	84	201	in	in	IN
en-wikipedia-org-4107	84	202	which	which	WDT
en-wikipedia-org-4107	84	203	the	the	DT
en-wikipedia-org-4107	84	204	use	use	NN
en-wikipedia-org-4107	84	205	of	of	IN
en-wikipedia-org-4107	84	206	substances	substance	NNS
en-wikipedia-org-4107	84	207	leads	lead	VBZ
en-wikipedia-org-4107	84	208	to	to	IN
en-wikipedia-org-4107	84	209	clinically	clinically	RB
en-wikipedia-org-4107	84	210	and	and	CC
en-wikipedia-org-4107	84	211	functionally	functionally	RB
en-wikipedia-org-4107	84	212	significant	significant	JJ
en-wikipedia-org-4107	84	213	impairment	impairment	NN
en-wikipedia-org-4107	84	214	or	or	CC
en-wikipedia-org-4107	84	215	distress	distress	NN
en-wikipedia-org-4107	84	216	tolerance	tolerance	NN
en-wikipedia-org-4107	84	217	–	–	:
en-wikipedia-org-4107	84	218	the	the	DT
en-wikipedia-org-4107	84	219	diminishing	diminish	VBG
en-wikipedia-org-4107	84	220	effect	effect	NN
en-wikipedia-org-4107	84	221	of	of	IN
en-wikipedia-org-4107	84	222	a	a	DT
en-wikipedia-org-4107	84	223	drug	drug	NN
en-wikipedia-org-4107	84	224	resulting	result	VBG
en-wikipedia-org-4107	84	225	from	from	IN
en-wikipedia-org-4107	84	226	repeated	repeat	VBN
en-wikipedia-org-4107	84	227	administration	administration	NN
en-wikipedia-org-4107	84	228	at	at	IN
en-wikipedia-org-4107	84	229	a	a	DT
en-wikipedia-org-4107	84	230	given	give	VBN
en-wikipedia-org-4107	84	231	dose	dose	NN
en-wikipedia-org-4107	84	232	v	v	NNP
en-wikipedia-org-4107	84	233	t	t	NN
en-wikipedia-org-4107	84	234	e	e	NNP
en-wikipedia-org-4107	84	235	Transcription	Transcription	NNP
en-wikipedia-org-4107	84	236	factor	factor	NN
en-wikipedia-org-4107	84	237	glossary	glossary	JJ
en-wikipedia-org-4107	84	238	gene	gene	NN
en-wikipedia-org-4107	84	239	expression	expression	NN
en-wikipedia-org-4107	84	240	–	–	:
en-wikipedia-org-4107	84	241	the	the	DT
en-wikipedia-org-4107	84	242	process	process	NN
en-wikipedia-org-4107	84	243	by	by	IN
en-wikipedia-org-4107	84	244	which	which	WDT
en-wikipedia-org-4107	84	245	information	information	NN
en-wikipedia-org-4107	84	246	from	from	IN
en-wikipedia-org-4107	84	247	a	a	DT
en-wikipedia-org-4107	84	248	gene	gene	NN
en-wikipedia-org-4107	84	249	is	be	VBZ
en-wikipedia-org-4107	84	250	used	use	VBN
en-wikipedia-org-4107	84	251	in	in	IN
en-wikipedia-org-4107	84	252	the	the	DT
en-wikipedia-org-4107	84	253	synthesis	synthesis	NN
en-wikipedia-org-4107	84	254	of	of	IN
en-wikipedia-org-4107	84	255	a	a	DT
en-wikipedia-org-4107	84	256	functional	functional	JJ
en-wikipedia-org-4107	84	257	gene	gene	NN
en-wikipedia-org-4107	84	258	product	product	NN
en-wikipedia-org-4107	84	259	such	such	JJ
en-wikipedia-org-4107	84	260	as	as	IN
en-wikipedia-org-4107	84	261	a	a	DT
en-wikipedia-org-4107	84	262	protein	protein	NN
en-wikipedia-org-4107	84	263	transcription	transcription	NN
en-wikipedia-org-4107	84	264	–	–	:
en-wikipedia-org-4107	84	265	the	the	DT
en-wikipedia-org-4107	84	266	process	process	NN
en-wikipedia-org-4107	84	267	of	of	IN
en-wikipedia-org-4107	84	268	making	make	VBG
en-wikipedia-org-4107	84	269	messenger	messenger	NN
en-wikipedia-org-4107	84	270	RNA	RNA	NNP
en-wikipedia-org-4107	84	271	(	(	-LRB-
en-wikipedia-org-4107	84	272	mRNA	mRNA	NNP
en-wikipedia-org-4107	84	273	)	)	-RRB-
en-wikipedia-org-4107	84	274	from	from	IN
en-wikipedia-org-4107	84	275	a	a	DT
en-wikipedia-org-4107	84	276	DNA	dna	NN
en-wikipedia-org-4107	84	277	template	template	NN
en-wikipedia-org-4107	84	278	by	by	IN
en-wikipedia-org-4107	84	279	RNA	RNA	NNP
en-wikipedia-org-4107	84	280	polymerase	polymerase	NNP
en-wikipedia-org-4107	84	281	transcription	transcription	NNP
en-wikipedia-org-4107	84	282	factor	factor	NN
en-wikipedia-org-4107	84	283	–	–	:
en-wikipedia-org-4107	84	284	a	a	DT
en-wikipedia-org-4107	84	285	protein	protein	NN
en-wikipedia-org-4107	84	286	that	that	WDT
en-wikipedia-org-4107	84	287	binds	bind	VBZ
en-wikipedia-org-4107	84	288	to	to	IN
en-wikipedia-org-4107	84	289	DNA	dna	NN
en-wikipedia-org-4107	84	290	and	and	CC
en-wikipedia-org-4107	84	291	regulates	regulate	VBZ
en-wikipedia-org-4107	84	292	gene	gene	NN
en-wikipedia-org-4107	84	293	expression	expression	NN
en-wikipedia-org-4107	84	294	by	by	IN
en-wikipedia-org-4107	84	295	promoting	promote	VBG
en-wikipedia-org-4107	84	296	or	or	CC
en-wikipedia-org-4107	84	297	suppressing	suppress	VBG
en-wikipedia-org-4107	84	298	transcription	transcription	NN
en-wikipedia-org-4107	84	299	transcriptional	transcriptional	JJ
en-wikipedia-org-4107	84	300	regulation	regulation	NN
en-wikipedia-org-4107	84	301	–	–	:
en-wikipedia-org-4107	84	302	controlling	control	VBG
en-wikipedia-org-4107	84	303	the	the	DT
en-wikipedia-org-4107	84	304	rate	rate	NN
en-wikipedia-org-4107	84	305	of	of	IN
en-wikipedia-org-4107	84	306	gene	gene	NN
en-wikipedia-org-4107	84	307	transcription	transcription	NN
en-wikipedia-org-4107	84	308	for	for	IN
en-wikipedia-org-4107	84	309	example	example	NN
en-wikipedia-org-4107	84	310	by	by	IN
en-wikipedia-org-4107	84	311	helping	help	VBG
en-wikipedia-org-4107	84	312	or	or	CC
en-wikipedia-org-4107	84	313	hindering	hinder	VBG
en-wikipedia-org-4107	84	314	RNA	RNA	NNP
en-wikipedia-org-4107	84	315	polymerase	polymerase	NN
en-wikipedia-org-4107	84	316	binding	bind	VBG
en-wikipedia-org-4107	84	317	to	to	IN
en-wikipedia-org-4107	84	318	DNA	dna	NN
en-wikipedia-org-4107	84	319	upregulation	upregulation	NN
en-wikipedia-org-4107	84	320	,	,	,
en-wikipedia-org-4107	84	321	activation	activation	NN
en-wikipedia-org-4107	84	322	,	,	,
en-wikipedia-org-4107	84	323	or	or	CC
en-wikipedia-org-4107	84	324	promotion	promotion	NN
en-wikipedia-org-4107	84	325	–	–	:
en-wikipedia-org-4107	84	326	increase	increase	VB
en-wikipedia-org-4107	84	327	the	the	DT
en-wikipedia-org-4107	84	328	rate	rate	NN
en-wikipedia-org-4107	84	329	of	of	IN
en-wikipedia-org-4107	84	330	gene	gene	NN
en-wikipedia-org-4107	84	331	transcription	transcription	NN
en-wikipedia-org-4107	84	332	downregulation	downregulation	NN
en-wikipedia-org-4107	84	333	,	,	,
en-wikipedia-org-4107	84	334	repression	repression	NN
en-wikipedia-org-4107	84	335	,	,	,
en-wikipedia-org-4107	84	336	or	or	CC
en-wikipedia-org-4107	84	337	suppression	suppression	NN
en-wikipedia-org-4107	84	338	–	–	:
en-wikipedia-org-4107	84	339	decrease	decrease	VB
en-wikipedia-org-4107	84	340	the	the	DT
en-wikipedia-org-4107	84	341	rate	rate	NN
en-wikipedia-org-4107	84	342	of	of	IN
en-wikipedia-org-4107	84	343	gene	gene	NN
en-wikipedia-org-4107	84	344	transcription	transcription	NN
en-wikipedia-org-4107	84	345	coactivator	coactivator	NN
en-wikipedia-org-4107	84	346	–	–	:
en-wikipedia-org-4107	84	347	a	a	DT
en-wikipedia-org-4107	84	348	protein	protein	NN
en-wikipedia-org-4107	84	349	(	(	-LRB-
en-wikipedia-org-4107	84	350	or	or	CC
en-wikipedia-org-4107	84	351	a	a	DT
en-wikipedia-org-4107	84	352	small	small	JJ
en-wikipedia-org-4107	84	353	molecule	molecule	NN
en-wikipedia-org-4107	84	354	)	)	-RRB-
en-wikipedia-org-4107	84	355	that	that	WDT
en-wikipedia-org-4107	84	356	works	work	VBZ
en-wikipedia-org-4107	84	357	with	with	IN
en-wikipedia-org-4107	84	358	transcription	transcription	NN
en-wikipedia-org-4107	84	359	factors	factor	NNS
en-wikipedia-org-4107	84	360	to	to	TO
en-wikipedia-org-4107	84	361	increase	increase	VB
en-wikipedia-org-4107	84	362	the	the	DT
en-wikipedia-org-4107	84	363	rate	rate	NN
en-wikipedia-org-4107	84	364	of	of	IN
en-wikipedia-org-4107	84	365	gene	gene	NN
en-wikipedia-org-4107	84	366	transcription	transcription	NNP
en-wikipedia-org-4107	84	367	corepressor	corepressor	NNP
en-wikipedia-org-4107	84	368	–	–	:
en-wikipedia-org-4107	84	369	a	a	DT
en-wikipedia-org-4107	84	370	protein	protein	NN
en-wikipedia-org-4107	84	371	(	(	-LRB-
en-wikipedia-org-4107	84	372	or	or	CC
en-wikipedia-org-4107	84	373	a	a	DT
en-wikipedia-org-4107	84	374	small	small	JJ
en-wikipedia-org-4107	84	375	molecule	molecule	NN
en-wikipedia-org-4107	84	376	)	)	-RRB-
en-wikipedia-org-4107	84	377	that	that	WDT
en-wikipedia-org-4107	84	378	works	work	VBZ
en-wikipedia-org-4107	84	379	with	with	IN
en-wikipedia-org-4107	84	380	transcription	transcription	NN
en-wikipedia-org-4107	84	381	factors	factor	NNS
en-wikipedia-org-4107	84	382	to	to	TO
en-wikipedia-org-4107	84	383	decrease	decrease	VB
en-wikipedia-org-4107	84	384	the	the	DT
en-wikipedia-org-4107	84	385	rate	rate	NN
en-wikipedia-org-4107	84	386	of	of	IN
en-wikipedia-org-4107	84	387	gene	gene	NN
en-wikipedia-org-4107	84	388	transcription	transcription	NN
en-wikipedia-org-4107	84	389	response	response	NN
en-wikipedia-org-4107	84	390	element	element	NN
en-wikipedia-org-4107	84	391	–	–	:
en-wikipedia-org-4107	84	392	a	a	DT
en-wikipedia-org-4107	84	393	specific	specific	JJ
en-wikipedia-org-4107	84	394	sequence	sequence	NN
en-wikipedia-org-4107	84	395	of	of	IN
en-wikipedia-org-4107	84	396	DNA	dna	NN
en-wikipedia-org-4107	84	397	that	that	IN
en-wikipedia-org-4107	84	398	a	a	DT
en-wikipedia-org-4107	84	399	transcription	transcription	NN
en-wikipedia-org-4107	84	400	factor	factor	NN
en-wikipedia-org-4107	84	401	binds	bind	NNS
en-wikipedia-org-4107	84	402	to	to	IN
en-wikipedia-org-4107	84	403	v	v	NN
en-wikipedia-org-4107	84	404	t	t	NN
en-wikipedia-org-4107	84	405	e	e	NNP
en-wikipedia-org-4107	84	406	Signaling	signal	VBG
en-wikipedia-org-4107	84	407	cascade	cascade	NN
en-wikipedia-org-4107	84	408	in	in	IN
en-wikipedia-org-4107	84	409	the	the	DT
en-wikipedia-org-4107	84	410	nucleus	nucleus	NN
en-wikipedia-org-4107	84	411	accumbens	accumben	VBZ
en-wikipedia-org-4107	84	412	that	that	WDT
en-wikipedia-org-4107	84	413	results	result	VBZ
en-wikipedia-org-4107	84	414	in	in	IN
en-wikipedia-org-4107	84	415	amphetamine	amphetamine	NN
en-wikipedia-org-4107	84	416	addiction	addiction	NN
en-wikipedia-org-4107	84	417	v	v	NNP
en-wikipedia-org-4107	84	418	t	t	NNP
en-wikipedia-org-4107	84	419	e	e	NNP
en-wikipedia-org-4107	84	420	Note	note	NN
en-wikipedia-org-4107	84	421	:	:	:
en-wikipedia-org-4107	84	422	colored	colored	JJ
en-wikipedia-org-4107	84	423	text	text	NN
en-wikipedia-org-4107	84	424	contains	contain	VBZ
en-wikipedia-org-4107	84	425	article	article	NN
en-wikipedia-org-4107	84	426	links	link	NNS
en-wikipedia-org-4107	84	427	.	.	.
en-wikipedia-org-4107	85	1	Nuclear	nuclear	JJ
en-wikipedia-org-4107	85	2	pore	pore	NN
en-wikipedia-org-4107	85	3	Nuclear	nuclear	JJ
en-wikipedia-org-4107	85	4	membrane	membrane	NN
en-wikipedia-org-4107	85	5	Plasma	Plasma	NNP
en-wikipedia-org-4107	85	6	membrane	membrane	NN
en-wikipedia-org-4107	85	7	Cav1.2	Cav1.2	NNP
en-wikipedia-org-4107	85	8	NMDAR	NMDAR	NNP
en-wikipedia-org-4107	85	9	AMPAR	AMPAR	NNP
en-wikipedia-org-4107	85	10	DRD1	DRD1	NNP
en-wikipedia-org-4107	85	11	DRD5	DRD5	NNP
en-wikipedia-org-4107	85	12	DRD2	DRD2	NNP
en-wikipedia-org-4107	85	13	DRD3	DRD3	NNP
en-wikipedia-org-4107	85	14	DRD4	DRD4	NNP
en-wikipedia-org-4107	85	15	Gs	Gs	NNP
en-wikipedia-org-4107	85	16	Gi	Gi	NNP
en-wikipedia-org-4107	85	17	/	/	,
en-wikipedia-org-4107	85	18	o	o	NN
en-wikipedia-org-4107	85	19	AC	AC	NNP
en-wikipedia-org-4107	85	20	cAMP	camp	NN
en-wikipedia-org-4107	85	21	cAMP	camp	NN
en-wikipedia-org-4107	85	22	PKA	PKA	NNP
en-wikipedia-org-4107	85	23	CaM	CaM	NNP
en-wikipedia-org-4107	85	24	CaMKII	CaMKII	NNS
en-wikipedia-org-4107	85	25	DARPP-32	DARPP-32	,
en-wikipedia-org-4107	85	26	PP1	PP1	NNP
en-wikipedia-org-4107	85	27	PP2B	PP2B	NNPS
en-wikipedia-org-4107	85	28	CREB	CREB	NNP
en-wikipedia-org-4107	85	29	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	85	30	JunD	JunD	NNP
en-wikipedia-org-4107	85	31	c	c	NNP
en-wikipedia-org-4107	85	32	-	-	:
en-wikipedia-org-4107	85	33	Fos	fos	JJ
en-wikipedia-org-4107	85	34	SIRT1	SIRT1	NNS
en-wikipedia-org-4107	85	35	HDAC1	hdac1	ADD
en-wikipedia-org-4107	85	36	[	[	-LRB-
en-wikipedia-org-4107	85	37	Color	color	NN
en-wikipedia-org-4107	85	38	legend	legend	NN
en-wikipedia-org-4107	85	39	1	1	CD
en-wikipedia-org-4107	85	40	]	]	-RRB-
en-wikipedia-org-4107	85	41	This	this	DT
en-wikipedia-org-4107	85	42	diagram	diagram	NN
en-wikipedia-org-4107	85	43	depicts	depict	VBZ
en-wikipedia-org-4107	85	44	the	the	DT
en-wikipedia-org-4107	85	45	signaling	signal	VBG
en-wikipedia-org-4107	85	46	events	event	NNS
en-wikipedia-org-4107	85	47	in	in	IN
en-wikipedia-org-4107	85	48	the	the	DT
en-wikipedia-org-4107	85	49	brain	brain	NN
en-wikipedia-org-4107	85	50	's	's	POS
en-wikipedia-org-4107	85	51	reward	reward	NN
en-wikipedia-org-4107	85	52	center	center	NN
en-wikipedia-org-4107	85	53	that	that	WDT
en-wikipedia-org-4107	85	54	are	be	VBP
en-wikipedia-org-4107	85	55	induced	induce	VBN
en-wikipedia-org-4107	85	56	by	by	IN
en-wikipedia-org-4107	85	57	chronic	chronic	JJ
en-wikipedia-org-4107	85	58	high	high	RB
en-wikipedia-org-4107	85	59	-	-	HYPH
en-wikipedia-org-4107	85	60	dose	dose	NN
en-wikipedia-org-4107	85	61	exposure	exposure	NN
en-wikipedia-org-4107	85	62	to	to	IN
en-wikipedia-org-4107	85	63	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	85	64	that	that	WDT
en-wikipedia-org-4107	85	65	increase	increase	VBP
en-wikipedia-org-4107	85	66	the	the	DT
en-wikipedia-org-4107	85	67	concentration	concentration	NN
en-wikipedia-org-4107	85	68	of	of	IN
en-wikipedia-org-4107	85	69	synaptic	synaptic	JJ
en-wikipedia-org-4107	85	70	dopamine	dopamine	NN
en-wikipedia-org-4107	85	71	,	,	,
en-wikipedia-org-4107	85	72	like	like	IN
en-wikipedia-org-4107	85	73	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	85	74	,	,	,
en-wikipedia-org-4107	85	75	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	85	76	,	,	,
en-wikipedia-org-4107	85	77	and	and	CC
en-wikipedia-org-4107	85	78	phenethylamine	phenethylamine	NN
en-wikipedia-org-4107	85	79	.	.	.
en-wikipedia-org-4107	86	1	Following	follow	VBG
en-wikipedia-org-4107	86	2	presynaptic	presynaptic	JJ
en-wikipedia-org-4107	86	3	dopamine	dopamine	NN
en-wikipedia-org-4107	86	4	and	and	CC
en-wikipedia-org-4107	86	5	glutamate	glutamate	NN
en-wikipedia-org-4107	86	6	co	co	JJ
en-wikipedia-org-4107	86	7	-	-	NN
en-wikipedia-org-4107	86	8	release	release	JJ
en-wikipedia-org-4107	86	9	by	by	IN
en-wikipedia-org-4107	86	10	such	such	JJ
en-wikipedia-org-4107	86	11	psychostimulants,[100][101	psychostimulants,[100][101	NN
en-wikipedia-org-4107	86	12	]	]	-RRB-
en-wikipedia-org-4107	86	13	postsynaptic	postsynaptic	JJ
en-wikipedia-org-4107	86	14	receptors	receptor	NNS
en-wikipedia-org-4107	86	15	for	for	IN
en-wikipedia-org-4107	86	16	these	these	DT
en-wikipedia-org-4107	86	17	neurotransmitters	neurotransmitter	NNS
en-wikipedia-org-4107	86	18	trigger	trigger	VBP
en-wikipedia-org-4107	86	19	internal	internal	JJ
en-wikipedia-org-4107	86	20	signaling	signal	VBG
en-wikipedia-org-4107	86	21	events	event	NNS
en-wikipedia-org-4107	86	22	through	through	IN
en-wikipedia-org-4107	86	23	a	a	DT
en-wikipedia-org-4107	86	24	cAMP	camp	NN
en-wikipedia-org-4107	86	25	-	-	HYPH
en-wikipedia-org-4107	86	26	dependent	dependent	JJ
en-wikipedia-org-4107	86	27	pathway	pathway	NN
en-wikipedia-org-4107	86	28	and	and	CC
en-wikipedia-org-4107	86	29	a	a	DT
en-wikipedia-org-4107	86	30	calcium	calcium	NN
en-wikipedia-org-4107	86	31	-	-	HYPH
en-wikipedia-org-4107	86	32	dependent	dependent	JJ
en-wikipedia-org-4107	86	33	pathway	pathway	NN
en-wikipedia-org-4107	86	34	that	that	WDT
en-wikipedia-org-4107	86	35	ultimately	ultimately	RB
en-wikipedia-org-4107	86	36	result	result	VBP
en-wikipedia-org-4107	86	37	in	in	IN
en-wikipedia-org-4107	86	38	increased	increase	VBN
en-wikipedia-org-4107	86	39	CREB	CREB	NNP
en-wikipedia-org-4107	86	40	phosphorylation	phosphorylation	NN
en-wikipedia-org-4107	86	41	.	.	.
en-wikipedia-org-4107	87	1	[	[	-LRB-
en-wikipedia-org-4107	87	2	100][102	100][102	CD
en-wikipedia-org-4107	87	3	]	]	-RRB-
en-wikipedia-org-4107	87	4	Phosphorylated	Phosphorylated	NNP
en-wikipedia-org-4107	87	5	CREB	CREB	NNP
en-wikipedia-org-4107	87	6	increases	increase	VBZ
en-wikipedia-org-4107	87	7	levels	level	NNS
en-wikipedia-org-4107	87	8	of	of	IN
en-wikipedia-org-4107	87	9	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	87	10	,	,	,
en-wikipedia-org-4107	87	11	which	which	WDT
en-wikipedia-org-4107	87	12	in	in	IN
en-wikipedia-org-4107	87	13	turn	turn	NN
en-wikipedia-org-4107	87	14	represses	repress	VBZ
en-wikipedia-org-4107	87	15	the	the	DT
en-wikipedia-org-4107	87	16	c	c	NN
en-wikipedia-org-4107	87	17	-	-	HYPH
en-wikipedia-org-4107	87	18	Fos	fos	NN
en-wikipedia-org-4107	87	19	gene	gene	NN
en-wikipedia-org-4107	87	20	with	with	IN
en-wikipedia-org-4107	87	21	the	the	DT
en-wikipedia-org-4107	87	22	help	help	NN
en-wikipedia-org-4107	87	23	of	of	IN
en-wikipedia-org-4107	87	24	corepressors;[100][103][104	corepressors;[100][103][104	NNP
en-wikipedia-org-4107	87	25	]	]	-RRB-
en-wikipedia-org-4107	87	26	c	c	NN
en-wikipedia-org-4107	87	27	-	-	HYPH
en-wikipedia-org-4107	87	28	Fos	fos	NN
en-wikipedia-org-4107	87	29	repression	repression	NN
en-wikipedia-org-4107	87	30	acts	act	VBZ
en-wikipedia-org-4107	87	31	as	as	IN
en-wikipedia-org-4107	87	32	a	a	DT
en-wikipedia-org-4107	87	33	molecular	molecular	JJ
en-wikipedia-org-4107	87	34	switch	switch	NN
en-wikipedia-org-4107	87	35	that	that	WDT
en-wikipedia-org-4107	87	36	enables	enable	VBZ
en-wikipedia-org-4107	87	37	the	the	DT
en-wikipedia-org-4107	87	38	accumulation	accumulation	NN
en-wikipedia-org-4107	87	39	of	of	IN
en-wikipedia-org-4107	87	40	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	87	41	in	in	IN
en-wikipedia-org-4107	87	42	the	the	DT
en-wikipedia-org-4107	87	43	neuron	neuron	NN
en-wikipedia-org-4107	87	44	.	.	.
en-wikipedia-org-4107	88	1	[	[	-LRB-
en-wikipedia-org-4107	88	2	105	105	CD
en-wikipedia-org-4107	88	3	]	]	-RRB-
en-wikipedia-org-4107	88	4	A	a	DT
en-wikipedia-org-4107	88	5	highly	highly	RB
en-wikipedia-org-4107	88	6	stable	stable	JJ
en-wikipedia-org-4107	88	7	(	(	-LRB-
en-wikipedia-org-4107	88	8	phosphorylated	phosphorylated	JJ
en-wikipedia-org-4107	88	9	)	)	-RRB-
en-wikipedia-org-4107	88	10	form	form	NN
en-wikipedia-org-4107	88	11	of	of	IN
en-wikipedia-org-4107	88	12	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	88	13	,	,	,
en-wikipedia-org-4107	88	14	one	one	NN
en-wikipedia-org-4107	88	15	that	that	WDT
en-wikipedia-org-4107	88	16	persists	persist	VBZ
en-wikipedia-org-4107	88	17	in	in	IN
en-wikipedia-org-4107	88	18	neurons	neuron	NNS
en-wikipedia-org-4107	88	19	for	for	IN
en-wikipedia-org-4107	88	20	1–2	1–2	CD
en-wikipedia-org-4107	88	21	 	  	_SP
en-wikipedia-org-4107	88	22	months	month	NNS
en-wikipedia-org-4107	88	23	,	,	,
en-wikipedia-org-4107	88	24	slowly	slowly	RB
en-wikipedia-org-4107	88	25	accumulates	accumulate	VBZ
en-wikipedia-org-4107	88	26	following	follow	VBG
en-wikipedia-org-4107	88	27	repeated	repeat	VBN
en-wikipedia-org-4107	88	28	high	high	RB
en-wikipedia-org-4107	88	29	-	-	HYPH
en-wikipedia-org-4107	88	30	dose	dose	NN
en-wikipedia-org-4107	88	31	exposure	exposure	NN
en-wikipedia-org-4107	88	32	to	to	IN
en-wikipedia-org-4107	88	33	stimulants	stimulant	NNS
en-wikipedia-org-4107	88	34	through	through	IN
en-wikipedia-org-4107	88	35	this	this	DT
en-wikipedia-org-4107	88	36	process	process	NN
en-wikipedia-org-4107	88	37	.	.	.
en-wikipedia-org-4107	89	1	[	[	-LRB-
en-wikipedia-org-4107	89	2	103][104	103][104	CD
en-wikipedia-org-4107	89	3	]	]	-RRB-
en-wikipedia-org-4107	89	4	ΔFosB	ΔFosB	VBZ
en-wikipedia-org-4107	89	5	functions	function	NNS
en-wikipedia-org-4107	89	6	as	as	IN
en-wikipedia-org-4107	89	7	"	"	``
en-wikipedia-org-4107	89	8	one	one	CD
en-wikipedia-org-4107	89	9	of	of	IN
en-wikipedia-org-4107	89	10	the	the	DT
en-wikipedia-org-4107	89	11	master	master	NN
en-wikipedia-org-4107	89	12	control	control	NN
en-wikipedia-org-4107	89	13	proteins	protein	NNS
en-wikipedia-org-4107	89	14	"	"	''
en-wikipedia-org-4107	89	15	that	that	WDT
en-wikipedia-org-4107	89	16	produces	produce	VBZ
en-wikipedia-org-4107	89	17	addiction	addiction	NN
en-wikipedia-org-4107	89	18	-	-	HYPH
en-wikipedia-org-4107	89	19	related	relate	VBN
en-wikipedia-org-4107	89	20	structural	structural	JJ
en-wikipedia-org-4107	89	21	changes	change	NNS
en-wikipedia-org-4107	89	22	in	in	IN
en-wikipedia-org-4107	89	23	the	the	DT
en-wikipedia-org-4107	89	24	brain	brain	NN
en-wikipedia-org-4107	89	25	,	,	,
en-wikipedia-org-4107	89	26	and	and	CC
en-wikipedia-org-4107	89	27	upon	upon	IN
en-wikipedia-org-4107	89	28	sufficient	sufficient	JJ
en-wikipedia-org-4107	89	29	accumulation	accumulation	NN
en-wikipedia-org-4107	89	30	,	,	,
en-wikipedia-org-4107	89	31	with	with	IN
en-wikipedia-org-4107	89	32	the	the	DT
en-wikipedia-org-4107	89	33	help	help	NN
en-wikipedia-org-4107	89	34	of	of	IN
en-wikipedia-org-4107	89	35	its	-PRON-	PRP$
en-wikipedia-org-4107	89	36	downstream	downstream	JJ
en-wikipedia-org-4107	89	37	targets	target	NNS
en-wikipedia-org-4107	89	38	(	(	-LRB-
en-wikipedia-org-4107	89	39	e.g.	e.g.	RB
en-wikipedia-org-4107	89	40	,	,	,
en-wikipedia-org-4107	89	41	nuclear	nuclear	JJ
en-wikipedia-org-4107	89	42	factor	factor	NN
en-wikipedia-org-4107	89	43	kappa	kappa	NNP
en-wikipedia-org-4107	89	44	B	B	NNP
en-wikipedia-org-4107	89	45	)	)	-RRB-
en-wikipedia-org-4107	89	46	,	,	,
en-wikipedia-org-4107	89	47	it	-PRON-	PRP
en-wikipedia-org-4107	89	48	induces	induce	VBZ
en-wikipedia-org-4107	89	49	an	an	DT
en-wikipedia-org-4107	89	50	addictive	addictive	JJ
en-wikipedia-org-4107	89	51	state	state	NN
en-wikipedia-org-4107	89	52	.	.	.
en-wikipedia-org-4107	90	1	[	[	-LRB-
en-wikipedia-org-4107	90	2	103][104	103][104	NNP
en-wikipedia-org-4107	90	3	]	]	-RRB-
en-wikipedia-org-4107	90	4	Addiction	addiction	NN
en-wikipedia-org-4107	90	5	is	be	VBZ
en-wikipedia-org-4107	90	6	a	a	DT
en-wikipedia-org-4107	90	7	serious	serious	JJ
en-wikipedia-org-4107	90	8	risk	risk	NN
en-wikipedia-org-4107	90	9	with	with	IN
en-wikipedia-org-4107	90	10	heavy	heavy	JJ
en-wikipedia-org-4107	90	11	recreational	recreational	JJ
en-wikipedia-org-4107	90	12	amphetamine	amphetamine	NN
en-wikipedia-org-4107	90	13	use	use	NN
en-wikipedia-org-4107	90	14	,	,	,
en-wikipedia-org-4107	90	15	but	but	CC
en-wikipedia-org-4107	90	16	is	be	VBZ
en-wikipedia-org-4107	90	17	unlikely	unlikely	JJ
en-wikipedia-org-4107	90	18	to	to	TO
en-wikipedia-org-4107	90	19	occur	occur	VB
en-wikipedia-org-4107	90	20	from	from	IN
en-wikipedia-org-4107	90	21	long	long	JJ
en-wikipedia-org-4107	90	22	-	-	HYPH
en-wikipedia-org-4107	90	23	term	term	NN
en-wikipedia-org-4107	90	24	medical	medical	JJ
en-wikipedia-org-4107	90	25	use	use	NN
en-wikipedia-org-4107	90	26	at	at	IN
en-wikipedia-org-4107	90	27	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	90	28	doses;[43][44][45	doses;[43][44][45	NN
en-wikipedia-org-4107	90	29	]	]	-RRB-
en-wikipedia-org-4107	90	30	in	in	IN
en-wikipedia-org-4107	90	31	fact	fact	NN
en-wikipedia-org-4107	90	32	,	,	,
en-wikipedia-org-4107	90	33	lifetime	lifetime	NN
en-wikipedia-org-4107	90	34	stimulant	stimulant	NN
en-wikipedia-org-4107	90	35	therapy	therapy	NN
en-wikipedia-org-4107	90	36	for	for	IN
en-wikipedia-org-4107	90	37	ADHD	ADHD	NNP
en-wikipedia-org-4107	90	38	that	that	WDT
en-wikipedia-org-4107	90	39	begins	begin	VBZ
en-wikipedia-org-4107	90	40	during	during	IN
en-wikipedia-org-4107	90	41	childhood	childhood	NN
en-wikipedia-org-4107	90	42	reduces	reduce	VBZ
en-wikipedia-org-4107	90	43	the	the	DT
en-wikipedia-org-4107	90	44	risk	risk	NN
en-wikipedia-org-4107	90	45	of	of	IN
en-wikipedia-org-4107	90	46	developing	develop	VBG
en-wikipedia-org-4107	90	47	substance	substance	NN
en-wikipedia-org-4107	90	48	use	use	NN
en-wikipedia-org-4107	90	49	disorders	disorder	NNS
en-wikipedia-org-4107	90	50	as	as	IN
en-wikipedia-org-4107	90	51	an	an	DT
en-wikipedia-org-4107	90	52	adult	adult	NN
en-wikipedia-org-4107	90	53	.	.	.
en-wikipedia-org-4107	91	1	[	[	-LRB-
en-wikipedia-org-4107	91	2	43	43	CD
en-wikipedia-org-4107	91	3	]	]	-RRB-
en-wikipedia-org-4107	91	4	Pathological	pathological	JJ
en-wikipedia-org-4107	91	5	overactivation	overactivation	NN
en-wikipedia-org-4107	91	6	of	of	IN
en-wikipedia-org-4107	91	7	the	the	DT
en-wikipedia-org-4107	91	8	mesolimbic	mesolimbic	JJ
en-wikipedia-org-4107	91	9	pathway	pathway	NN
en-wikipedia-org-4107	91	10	,	,	,
en-wikipedia-org-4107	91	11	a	a	DT
en-wikipedia-org-4107	91	12	dopamine	dopamine	NN
en-wikipedia-org-4107	91	13	pathway	pathway	NN
en-wikipedia-org-4107	91	14	that	that	WDT
en-wikipedia-org-4107	91	15	connects	connect	VBZ
en-wikipedia-org-4107	91	16	the	the	DT
en-wikipedia-org-4107	91	17	ventral	ventral	JJ
en-wikipedia-org-4107	91	18	tegmental	tegmental	JJ
en-wikipedia-org-4107	91	19	area	area	NN
en-wikipedia-org-4107	91	20	to	to	IN
en-wikipedia-org-4107	91	21	the	the	DT
en-wikipedia-org-4107	91	22	nucleus	nucleus	NN
en-wikipedia-org-4107	91	23	accumbens	accumbens	NNPS
en-wikipedia-org-4107	91	24	,	,	,
en-wikipedia-org-4107	91	25	plays	play	VBZ
en-wikipedia-org-4107	91	26	a	a	DT
en-wikipedia-org-4107	91	27	central	central	JJ
en-wikipedia-org-4107	91	28	role	role	NN
en-wikipedia-org-4107	91	29	in	in	IN
en-wikipedia-org-4107	91	30	amphetamine	amphetamine	NN
en-wikipedia-org-4107	91	31	addiction	addiction	NN
en-wikipedia-org-4107	91	32	.	.	.
en-wikipedia-org-4107	92	1	[	[	-LRB-
en-wikipedia-org-4107	92	2	106][107	106][107	LS
en-wikipedia-org-4107	92	3	]	]	-RRB-
en-wikipedia-org-4107	92	4	Individuals	individual	NNS
en-wikipedia-org-4107	92	5	who	who	WP
en-wikipedia-org-4107	92	6	frequently	frequently	RB
en-wikipedia-org-4107	92	7	self	self	VBP
en-wikipedia-org-4107	92	8	-	-	HYPH
en-wikipedia-org-4107	92	9	administer	administer	NN
en-wikipedia-org-4107	92	10	high	high	JJ
en-wikipedia-org-4107	92	11	doses	dose	NNS
en-wikipedia-org-4107	92	12	of	of	IN
en-wikipedia-org-4107	92	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	92	14	have	have	VBP
en-wikipedia-org-4107	92	15	a	a	DT
en-wikipedia-org-4107	92	16	high	high	JJ
en-wikipedia-org-4107	92	17	risk	risk	NN
en-wikipedia-org-4107	92	18	of	of	IN
en-wikipedia-org-4107	92	19	developing	develop	VBG
en-wikipedia-org-4107	92	20	an	an	DT
en-wikipedia-org-4107	92	21	amphetamine	amphetamine	NN
en-wikipedia-org-4107	92	22	addiction	addiction	NN
en-wikipedia-org-4107	92	23	,	,	,
en-wikipedia-org-4107	92	24	since	since	IN
en-wikipedia-org-4107	92	25	chronic	chronic	JJ
en-wikipedia-org-4107	92	26	use	use	NN
en-wikipedia-org-4107	92	27	at	at	IN
en-wikipedia-org-4107	92	28	high	high	JJ
en-wikipedia-org-4107	92	29	doses	dose	NNS
en-wikipedia-org-4107	92	30	gradually	gradually	RB
en-wikipedia-org-4107	92	31	increase	increase	VB
en-wikipedia-org-4107	92	32	the	the	DT
en-wikipedia-org-4107	92	33	level	level	NN
en-wikipedia-org-4107	92	34	of	of	IN
en-wikipedia-org-4107	92	35	accumbal	accumbal	NN
en-wikipedia-org-4107	92	36	ΔFosB	ΔFosB	NNS
en-wikipedia-org-4107	92	37	,	,	,
en-wikipedia-org-4107	92	38	a	a	DT
en-wikipedia-org-4107	92	39	"	"	``
en-wikipedia-org-4107	92	40	molecular	molecular	JJ
en-wikipedia-org-4107	92	41	switch	switch	NN
en-wikipedia-org-4107	92	42	"	"	''
en-wikipedia-org-4107	92	43	and	and	CC
en-wikipedia-org-4107	92	44	"	"	``
en-wikipedia-org-4107	92	45	master	master	NN
en-wikipedia-org-4107	92	46	control	control	NN
en-wikipedia-org-4107	92	47	protein	protein	NN
en-wikipedia-org-4107	92	48	"	"	''
en-wikipedia-org-4107	92	49	for	for	IN
en-wikipedia-org-4107	92	50	addiction	addiction	NN
en-wikipedia-org-4107	92	51	.	.	.
en-wikipedia-org-4107	93	1	[	[	-LRB-
en-wikipedia-org-4107	93	2	97][108][109	97][108][109	NN
en-wikipedia-org-4107	93	3	]	]	-RRB-
en-wikipedia-org-4107	93	4	Once	once	IN
en-wikipedia-org-4107	93	5	nucleus	nucleus	NN
en-wikipedia-org-4107	93	6	accumbens	accumben	NNS
en-wikipedia-org-4107	93	7	ΔFosB	ΔFosB	VBZ
en-wikipedia-org-4107	93	8	is	be	VBZ
en-wikipedia-org-4107	93	9	sufficiently	sufficiently	RB
en-wikipedia-org-4107	93	10	overexpressed	overexpresse	VBN
en-wikipedia-org-4107	93	11	,	,	,
en-wikipedia-org-4107	93	12	it	-PRON-	PRP
en-wikipedia-org-4107	93	13	begins	begin	VBZ
en-wikipedia-org-4107	93	14	to	to	TO
en-wikipedia-org-4107	93	15	increase	increase	VB
en-wikipedia-org-4107	93	16	the	the	DT
en-wikipedia-org-4107	93	17	severity	severity	NN
en-wikipedia-org-4107	93	18	of	of	IN
en-wikipedia-org-4107	93	19	addictive	addictive	JJ
en-wikipedia-org-4107	93	20	behavior	behavior	NN
en-wikipedia-org-4107	93	21	(	(	-LRB-
en-wikipedia-org-4107	93	22	i.e.	i.e.	FW
en-wikipedia-org-4107	93	23	,	,	,
en-wikipedia-org-4107	93	24	compulsive	compulsive	JJ
en-wikipedia-org-4107	93	25	drug	drug	NN
en-wikipedia-org-4107	93	26	-	-	HYPH
en-wikipedia-org-4107	93	27	seeking	seeking	NN
en-wikipedia-org-4107	93	28	)	)	-RRB-
en-wikipedia-org-4107	93	29	with	with	IN
en-wikipedia-org-4107	93	30	further	further	JJ
en-wikipedia-org-4107	93	31	increases	increase	NNS
en-wikipedia-org-4107	93	32	in	in	IN
en-wikipedia-org-4107	93	33	its	-PRON-	PRP$
en-wikipedia-org-4107	93	34	expression	expression	NN
en-wikipedia-org-4107	93	35	.	.	.
en-wikipedia-org-4107	94	1	[	[	-LRB-
en-wikipedia-org-4107	94	2	108][110	108][110	LS
en-wikipedia-org-4107	94	3	]	]	-RRB-
en-wikipedia-org-4107	94	4	While	while	IN
en-wikipedia-org-4107	94	5	there	there	EX
en-wikipedia-org-4107	94	6	are	be	VBP
en-wikipedia-org-4107	94	7	currently	currently	RB
en-wikipedia-org-4107	94	8	no	no	DT
en-wikipedia-org-4107	94	9	effective	effective	JJ
en-wikipedia-org-4107	94	10	drugs	drug	NNS
en-wikipedia-org-4107	94	11	for	for	IN
en-wikipedia-org-4107	94	12	treating	treat	VBG
en-wikipedia-org-4107	94	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	94	14	addiction	addiction	NN
en-wikipedia-org-4107	94	15	,	,	,
en-wikipedia-org-4107	94	16	regularly	regularly	RB
en-wikipedia-org-4107	94	17	engaging	engage	VBG
en-wikipedia-org-4107	94	18	in	in	IN
en-wikipedia-org-4107	94	19	sustained	sustained	JJ
en-wikipedia-org-4107	94	20	aerobic	aerobic	JJ
en-wikipedia-org-4107	94	21	exercise	exercise	NN
en-wikipedia-org-4107	94	22	appears	appear	VBZ
en-wikipedia-org-4107	94	23	to	to	TO
en-wikipedia-org-4107	94	24	reduce	reduce	VB
en-wikipedia-org-4107	94	25	the	the	DT
en-wikipedia-org-4107	94	26	risk	risk	NN
en-wikipedia-org-4107	94	27	of	of	IN
en-wikipedia-org-4107	94	28	developing	develop	VBG
en-wikipedia-org-4107	94	29	such	such	PDT
en-wikipedia-org-4107	94	30	an	an	DT
en-wikipedia-org-4107	94	31	addiction	addiction	NN
en-wikipedia-org-4107	94	32	.	.	.
en-wikipedia-org-4107	95	1	[	[	-LRB-
en-wikipedia-org-4107	95	2	111][112	111][112	CD
en-wikipedia-org-4107	95	3	]	]	-RRB-
en-wikipedia-org-4107	95	4	Sustained	sustained	JJ
en-wikipedia-org-4107	95	5	aerobic	aerobic	JJ
en-wikipedia-org-4107	95	6	exercise	exercise	NN
en-wikipedia-org-4107	95	7	on	on	IN
en-wikipedia-org-4107	95	8	a	a	DT
en-wikipedia-org-4107	95	9	regular	regular	JJ
en-wikipedia-org-4107	95	10	basis	basis	NN
en-wikipedia-org-4107	95	11	also	also	RB
en-wikipedia-org-4107	95	12	appears	appear	VBZ
en-wikipedia-org-4107	95	13	to	to	TO
en-wikipedia-org-4107	95	14	be	be	VB
en-wikipedia-org-4107	95	15	an	an	DT
en-wikipedia-org-4107	95	16	effective	effective	JJ
en-wikipedia-org-4107	95	17	treatment	treatment	NN
en-wikipedia-org-4107	95	18	for	for	IN
en-wikipedia-org-4107	95	19	amphetamine	amphetamine	NN
en-wikipedia-org-4107	95	20	addiction;[sources	addiction;[source	NNS
en-wikipedia-org-4107	95	21	9	9	CD
en-wikipedia-org-4107	95	22	]	]	-RRB-
en-wikipedia-org-4107	95	23	exercise	exercise	NN
en-wikipedia-org-4107	95	24	therapy	therapy	NN
en-wikipedia-org-4107	95	25	improves	improve	VBZ
en-wikipedia-org-4107	95	26	clinical	clinical	JJ
en-wikipedia-org-4107	95	27	treatment	treatment	NN
en-wikipedia-org-4107	95	28	outcomes	outcome	NNS
en-wikipedia-org-4107	95	29	and	and	CC
en-wikipedia-org-4107	95	30	may	may	MD
en-wikipedia-org-4107	95	31	be	be	VB
en-wikipedia-org-4107	95	32	used	use	VBN
en-wikipedia-org-4107	95	33	as	as	IN
en-wikipedia-org-4107	95	34	an	an	DT
en-wikipedia-org-4107	95	35	adjunct	adjunct	JJ
en-wikipedia-org-4107	95	36	therapy	therapy	NN
en-wikipedia-org-4107	95	37	with	with	IN
en-wikipedia-org-4107	95	38	behavioral	behavioral	JJ
en-wikipedia-org-4107	95	39	therapies	therapy	NNS
en-wikipedia-org-4107	95	40	for	for	IN
en-wikipedia-org-4107	95	41	addiction	addiction	NN
en-wikipedia-org-4107	95	42	.	.	.
en-wikipedia-org-4107	96	1	[	[	-LRB-
en-wikipedia-org-4107	96	2	111][113	111][113	CD
en-wikipedia-org-4107	96	3	]	]	-RRB-
en-wikipedia-org-4107	96	4	Biomolecular	Biomolecular	NNP
en-wikipedia-org-4107	96	5	mechanisms	mechanism	NNS
en-wikipedia-org-4107	96	6	Chronic	chronic	JJ
en-wikipedia-org-4107	96	7	use	use	NN
en-wikipedia-org-4107	96	8	of	of	IN
en-wikipedia-org-4107	96	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	96	10	at	at	IN
en-wikipedia-org-4107	96	11	excessive	excessive	JJ
en-wikipedia-org-4107	96	12	doses	dose	NNS
en-wikipedia-org-4107	96	13	causes	cause	VBZ
en-wikipedia-org-4107	96	14	alterations	alteration	NNS
en-wikipedia-org-4107	96	15	in	in	IN
en-wikipedia-org-4107	96	16	gene	gene	NN
en-wikipedia-org-4107	96	17	expression	expression	NN
en-wikipedia-org-4107	96	18	in	in	IN
en-wikipedia-org-4107	96	19	the	the	DT
en-wikipedia-org-4107	96	20	mesocorticolimbic	mesocorticolimbic	JJ
en-wikipedia-org-4107	96	21	projection	projection	NN
en-wikipedia-org-4107	96	22	,	,	,
en-wikipedia-org-4107	96	23	which	which	WDT
en-wikipedia-org-4107	96	24	arise	arise	VBP
en-wikipedia-org-4107	96	25	through	through	IN
en-wikipedia-org-4107	96	26	transcriptional	transcriptional	JJ
en-wikipedia-org-4107	96	27	and	and	CC
en-wikipedia-org-4107	96	28	epigenetic	epigenetic	JJ
en-wikipedia-org-4107	96	29	mechanisms	mechanism	NNS
en-wikipedia-org-4107	96	30	.	.	.
en-wikipedia-org-4107	97	1	[	[	-LRB-
en-wikipedia-org-4107	97	2	109][114][115	109][114][115	CD
en-wikipedia-org-4107	97	3	]	]	-RRB-
en-wikipedia-org-4107	97	4	The	the	DT
en-wikipedia-org-4107	97	5	most	most	RBS
en-wikipedia-org-4107	97	6	important	important	JJ
en-wikipedia-org-4107	97	7	transcription	transcription	NN
en-wikipedia-org-4107	97	8	factors[note	factors[note	CD
en-wikipedia-org-4107	97	9	11	11	CD
en-wikipedia-org-4107	97	10	]	]	-RRB-
en-wikipedia-org-4107	97	11	that	that	WDT
en-wikipedia-org-4107	97	12	produce	produce	VBP
en-wikipedia-org-4107	97	13	these	these	DT
en-wikipedia-org-4107	97	14	alterations	alteration	NNS
en-wikipedia-org-4107	97	15	are	be	VBP
en-wikipedia-org-4107	97	16	Delta	Delta	NNP
en-wikipedia-org-4107	97	17	FBJ	FBJ	NNP
en-wikipedia-org-4107	97	18	murine	murine	NN
en-wikipedia-org-4107	97	19	osteosarcoma	osteosarcoma	NNP
en-wikipedia-org-4107	97	20	viral	viral	NN
en-wikipedia-org-4107	97	21	oncogene	oncogene	NN
en-wikipedia-org-4107	97	22	homolog	homolog	NNP
en-wikipedia-org-4107	97	23	B	B	NNP
en-wikipedia-org-4107	97	24	(	(	-LRB-
en-wikipedia-org-4107	97	25	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	97	26	)	)	-RRB-
en-wikipedia-org-4107	97	27	,	,	,
en-wikipedia-org-4107	97	28	cAMP	camp	NN
en-wikipedia-org-4107	97	29	response	response	NN
en-wikipedia-org-4107	97	30	element	element	NN
en-wikipedia-org-4107	97	31	binding	bind	VBG
en-wikipedia-org-4107	97	32	protein	protein	NN
en-wikipedia-org-4107	97	33	(	(	-LRB-
en-wikipedia-org-4107	97	34	CREB	CREB	NNP
en-wikipedia-org-4107	97	35	)	)	-RRB-
en-wikipedia-org-4107	97	36	,	,	,
en-wikipedia-org-4107	97	37	and	and	CC
en-wikipedia-org-4107	97	38	nuclear	nuclear	JJ
en-wikipedia-org-4107	97	39	factor	factor	NN
en-wikipedia-org-4107	97	40	-	-	HYPH
en-wikipedia-org-4107	97	41	kappa	kappa	NNP
en-wikipedia-org-4107	97	42	B	B	NNP
en-wikipedia-org-4107	97	43	(	(	-LRB-
en-wikipedia-org-4107	97	44	NF	NF	NNP
en-wikipedia-org-4107	97	45	-	-	HYPH
en-wikipedia-org-4107	97	46	κB	κB	NNP
en-wikipedia-org-4107	97	47	)	)	-RRB-
en-wikipedia-org-4107	97	48	.	.	.
en-wikipedia-org-4107	98	1	[	[	-LRB-
en-wikipedia-org-4107	98	2	109	109	CD
en-wikipedia-org-4107	98	3	]	]	-RRB-
en-wikipedia-org-4107	98	4	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	98	5	is	be	VBZ
en-wikipedia-org-4107	98	6	the	the	DT
en-wikipedia-org-4107	98	7	most	most	RBS
en-wikipedia-org-4107	98	8	significant	significant	JJ
en-wikipedia-org-4107	98	9	biomolecular	biomolecular	JJ
en-wikipedia-org-4107	98	10	mechanism	mechanism	NN
en-wikipedia-org-4107	98	11	in	in	IN
en-wikipedia-org-4107	98	12	addiction	addiction	NN
en-wikipedia-org-4107	98	13	because	because	IN
en-wikipedia-org-4107	98	14	ΔFosB	δfosb	JJ
en-wikipedia-org-4107	98	15	overexpression	overexpression	NN
en-wikipedia-org-4107	98	16	(	(	-LRB-
en-wikipedia-org-4107	98	17	i.e.	i.e.	FW
en-wikipedia-org-4107	98	18	,	,	,
en-wikipedia-org-4107	98	19	an	an	DT
en-wikipedia-org-4107	98	20	abnormally	abnormally	RB
en-wikipedia-org-4107	98	21	high	high	JJ
en-wikipedia-org-4107	98	22	level	level	NN
en-wikipedia-org-4107	98	23	of	of	IN
en-wikipedia-org-4107	98	24	gene	gene	NN
en-wikipedia-org-4107	98	25	expression	expression	NN
en-wikipedia-org-4107	98	26	which	which	WDT
en-wikipedia-org-4107	98	27	produces	produce	VBZ
en-wikipedia-org-4107	98	28	a	a	DT
en-wikipedia-org-4107	98	29	pronounced	pronounced	JJ
en-wikipedia-org-4107	98	30	gene	gene	NN
en-wikipedia-org-4107	98	31	-	-	HYPH
en-wikipedia-org-4107	98	32	related	relate	VBN
en-wikipedia-org-4107	98	33	phenotype	phenotype	NN
en-wikipedia-org-4107	98	34	)	)	-RRB-
en-wikipedia-org-4107	98	35	in	in	IN
en-wikipedia-org-4107	98	36	the	the	DT
en-wikipedia-org-4107	98	37	D1-type	D1-type	NNP
en-wikipedia-org-4107	98	38	medium	medium	JJ
en-wikipedia-org-4107	98	39	spiny	spiny	JJ
en-wikipedia-org-4107	98	40	neurons	neuron	NNS
en-wikipedia-org-4107	98	41	in	in	IN
en-wikipedia-org-4107	98	42	the	the	DT
en-wikipedia-org-4107	98	43	nucleus	nucleus	NN
en-wikipedia-org-4107	98	44	accumbens	accumbens	NNPS
en-wikipedia-org-4107	98	45	is	be	VBZ
en-wikipedia-org-4107	98	46	necessary	necessary	JJ
en-wikipedia-org-4107	98	47	and	and	CC
en-wikipedia-org-4107	98	48	sufficient[note	sufficient[note	CD
en-wikipedia-org-4107	98	49	12	12	CD
en-wikipedia-org-4107	98	50	]	]	-RRB-
en-wikipedia-org-4107	98	51	for	for	IN
en-wikipedia-org-4107	98	52	many	many	JJ
en-wikipedia-org-4107	98	53	of	of	IN
en-wikipedia-org-4107	98	54	the	the	DT
en-wikipedia-org-4107	98	55	neural	neural	JJ
en-wikipedia-org-4107	98	56	adaptations	adaptation	NNS
en-wikipedia-org-4107	98	57	and	and	CC
en-wikipedia-org-4107	98	58	regulates	regulate	VBZ
en-wikipedia-org-4107	98	59	multiple	multiple	JJ
en-wikipedia-org-4107	98	60	behavioral	behavioral	JJ
en-wikipedia-org-4107	98	61	effects	effect	NNS
en-wikipedia-org-4107	98	62	(	(	-LRB-
en-wikipedia-org-4107	98	63	e.g.	e.g.	RB
en-wikipedia-org-4107	98	64	,	,	,
en-wikipedia-org-4107	98	65	reward	reward	VB
en-wikipedia-org-4107	98	66	sensitization	sensitization	NN
en-wikipedia-org-4107	98	67	and	and	CC
en-wikipedia-org-4107	98	68	escalating	escalate	VBG
en-wikipedia-org-4107	98	69	drug	drug	NN
en-wikipedia-org-4107	98	70	self	self	NN
en-wikipedia-org-4107	98	71	-	-	HYPH
en-wikipedia-org-4107	98	72	administration	administration	NN
en-wikipedia-org-4107	98	73	)	)	-RRB-
en-wikipedia-org-4107	98	74	involved	involve	VBN
en-wikipedia-org-4107	98	75	in	in	IN
en-wikipedia-org-4107	98	76	addiction	addiction	NN
en-wikipedia-org-4107	98	77	.	.	.
en-wikipedia-org-4107	99	1	[	[	-LRB-
en-wikipedia-org-4107	99	2	97][108][109	97][108][109	NN
en-wikipedia-org-4107	99	3	]	]	-RRB-
en-wikipedia-org-4107	99	4	Once	once	RB
en-wikipedia-org-4107	99	5	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	99	6	is	be	VBZ
en-wikipedia-org-4107	99	7	sufficiently	sufficiently	RB
en-wikipedia-org-4107	99	8	overexpressed	overexpresse	VBN
en-wikipedia-org-4107	99	9	,	,	,
en-wikipedia-org-4107	99	10	it	-PRON-	PRP
en-wikipedia-org-4107	99	11	induces	induce	VBZ
en-wikipedia-org-4107	99	12	an	an	DT
en-wikipedia-org-4107	99	13	addictive	addictive	JJ
en-wikipedia-org-4107	99	14	state	state	NN
en-wikipedia-org-4107	99	15	that	that	WDT
en-wikipedia-org-4107	99	16	becomes	become	VBZ
en-wikipedia-org-4107	99	17	increasingly	increasingly	RB
en-wikipedia-org-4107	99	18	more	more	RBR
en-wikipedia-org-4107	99	19	severe	severe	JJ
en-wikipedia-org-4107	99	20	with	with	IN
en-wikipedia-org-4107	99	21	further	further	JJ
en-wikipedia-org-4107	99	22	increases	increase	NNS
en-wikipedia-org-4107	99	23	in	in	IN
en-wikipedia-org-4107	99	24	ΔFosB	ΔFosB	VBN
en-wikipedia-org-4107	99	25	expression	expression	NN
en-wikipedia-org-4107	99	26	.	.	.
en-wikipedia-org-4107	100	1	[	[	-LRB-
en-wikipedia-org-4107	100	2	97][108	97][108	NN
en-wikipedia-org-4107	100	3	]	]	-RRB-
en-wikipedia-org-4107	100	4	It	-PRON-	PRP
en-wikipedia-org-4107	100	5	has	have	VBZ
en-wikipedia-org-4107	100	6	been	be	VBN
en-wikipedia-org-4107	100	7	implicated	implicate	VBN
en-wikipedia-org-4107	100	8	in	in	IN
en-wikipedia-org-4107	100	9	addictions	addiction	NNS
en-wikipedia-org-4107	100	10	to	to	IN
en-wikipedia-org-4107	100	11	alcohol	alcohol	NN
en-wikipedia-org-4107	100	12	,	,	,
en-wikipedia-org-4107	100	13	cannabinoids	cannabinoid	NNS
en-wikipedia-org-4107	100	14	,	,	,
en-wikipedia-org-4107	100	15	cocaine	cocaine	NN
en-wikipedia-org-4107	100	16	,	,	,
en-wikipedia-org-4107	100	17	methylphenidate	methylphenidate	NN
en-wikipedia-org-4107	100	18	,	,	,
en-wikipedia-org-4107	100	19	nicotine	nicotine	NN
en-wikipedia-org-4107	100	20	,	,	,
en-wikipedia-org-4107	100	21	opioids	opioids	NNP
en-wikipedia-org-4107	100	22	,	,	,
en-wikipedia-org-4107	100	23	phencyclidine	phencyclidine	NNP
en-wikipedia-org-4107	100	24	,	,	,
en-wikipedia-org-4107	100	25	propofol	propofol	NNP
en-wikipedia-org-4107	100	26	,	,	,
en-wikipedia-org-4107	100	27	and	and	CC
en-wikipedia-org-4107	100	28	substituted	substitute	VBN
en-wikipedia-org-4107	100	29	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	100	30	,	,	,
en-wikipedia-org-4107	100	31	among	among	IN
en-wikipedia-org-4107	100	32	others	other	NNS
en-wikipedia-org-4107	100	33	.	.	.
en-wikipedia-org-4107	101	1	[	[	-LRB-
en-wikipedia-org-4107	101	2	sources	source	NNS
en-wikipedia-org-4107	101	3	10	10	CD
en-wikipedia-org-4107	101	4	]	]	-RRB-
en-wikipedia-org-4107	101	5	ΔJunD	δjund	NN
en-wikipedia-org-4107	101	6	,	,	,
en-wikipedia-org-4107	101	7	a	a	DT
en-wikipedia-org-4107	101	8	transcription	transcription	NN
en-wikipedia-org-4107	101	9	factor	factor	NN
en-wikipedia-org-4107	101	10	,	,	,
en-wikipedia-org-4107	101	11	and	and	CC
en-wikipedia-org-4107	101	12	G9a	G9a	NNP
en-wikipedia-org-4107	101	13	,	,	,
en-wikipedia-org-4107	101	14	a	a	DT
en-wikipedia-org-4107	101	15	histone	histone	JJ
en-wikipedia-org-4107	101	16	methyltransferase	methyltransferase	NN
en-wikipedia-org-4107	101	17	enzyme	enzyme	NNS
en-wikipedia-org-4107	101	18	,	,	,
en-wikipedia-org-4107	101	19	both	both	DT
en-wikipedia-org-4107	101	20	oppose	oppose	VBP
en-wikipedia-org-4107	101	21	the	the	DT
en-wikipedia-org-4107	101	22	function	function	NN
en-wikipedia-org-4107	101	23	of	of	IN
en-wikipedia-org-4107	101	24	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	101	25	and	and	CC
en-wikipedia-org-4107	101	26	inhibit	inhibit	VB
en-wikipedia-org-4107	101	27	increases	increase	NNS
en-wikipedia-org-4107	101	28	in	in	IN
en-wikipedia-org-4107	101	29	its	-PRON-	PRP$
en-wikipedia-org-4107	101	30	expression	expression	NN
en-wikipedia-org-4107	101	31	.	.	.
en-wikipedia-org-4107	102	1	[	[	-LRB-
en-wikipedia-org-4107	102	2	97][109][119	97][109][119	NNP
en-wikipedia-org-4107	102	3	]	]	-RRB-
en-wikipedia-org-4107	102	4	Sufficiently	sufficiently	RB
en-wikipedia-org-4107	102	5	overexpressing	overexpresse	VBG
en-wikipedia-org-4107	102	6	ΔJunD	ΔJunD	NNPS
en-wikipedia-org-4107	102	7	in	in	IN
en-wikipedia-org-4107	102	8	the	the	DT
en-wikipedia-org-4107	102	9	nucleus	nucleus	NN
en-wikipedia-org-4107	102	10	accumbens	accumben	VBZ
en-wikipedia-org-4107	102	11	with	with	IN
en-wikipedia-org-4107	102	12	viral	viral	JJ
en-wikipedia-org-4107	102	13	vectors	vector	NNS
en-wikipedia-org-4107	102	14	can	can	MD
en-wikipedia-org-4107	102	15	completely	completely	RB
en-wikipedia-org-4107	102	16	block	block	VB
en-wikipedia-org-4107	102	17	many	many	JJ
en-wikipedia-org-4107	102	18	of	of	IN
en-wikipedia-org-4107	102	19	the	the	DT
en-wikipedia-org-4107	102	20	neural	neural	JJ
en-wikipedia-org-4107	102	21	and	and	CC
en-wikipedia-org-4107	102	22	behavioral	behavioral	JJ
en-wikipedia-org-4107	102	23	alterations	alteration	NNS
en-wikipedia-org-4107	102	24	seen	see	VBN
en-wikipedia-org-4107	102	25	in	in	IN
en-wikipedia-org-4107	102	26	chronic	chronic	JJ
en-wikipedia-org-4107	102	27	drug	drug	NN
en-wikipedia-org-4107	102	28	abuse	abuse	NN
en-wikipedia-org-4107	102	29	(	(	-LRB-
en-wikipedia-org-4107	102	30	i.e.	i.e.	FW
en-wikipedia-org-4107	102	31	,	,	,
en-wikipedia-org-4107	102	32	the	the	DT
en-wikipedia-org-4107	102	33	alterations	alteration	NNS
en-wikipedia-org-4107	102	34	mediated	mediate	VBN
en-wikipedia-org-4107	102	35	by	by	IN
en-wikipedia-org-4107	102	36	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	102	37	)	)	-RRB-
en-wikipedia-org-4107	102	38	.	.	.
en-wikipedia-org-4107	103	1	[	[	-LRB-
en-wikipedia-org-4107	103	2	109	109	CD
en-wikipedia-org-4107	103	3	]	]	-RRB-
en-wikipedia-org-4107	103	4	Similarly	similarly	RB
en-wikipedia-org-4107	103	5	,	,	,
en-wikipedia-org-4107	103	6	accumbal	accumbal	JJ
en-wikipedia-org-4107	103	7	G9a	G9a	NNP
en-wikipedia-org-4107	103	8	hyperexpression	hyperexpression	NN
en-wikipedia-org-4107	103	9	results	result	VBZ
en-wikipedia-org-4107	103	10	in	in	IN
en-wikipedia-org-4107	103	11	markedly	markedly	RB
en-wikipedia-org-4107	103	12	increased	increase	VBN
en-wikipedia-org-4107	103	13	histone	histone	NN
en-wikipedia-org-4107	103	14	3	3	CD
en-wikipedia-org-4107	103	15	lysine	lysine	NN
en-wikipedia-org-4107	103	16	residue	residue	NN
en-wikipedia-org-4107	103	17	9	9	CD
en-wikipedia-org-4107	103	18	dimethylation	dimethylation	NN
en-wikipedia-org-4107	103	19	(	(	-LRB-
en-wikipedia-org-4107	103	20	H3K9me2	H3K9me2	NNP
en-wikipedia-org-4107	103	21	)	)	-RRB-
en-wikipedia-org-4107	103	22	and	and	CC
en-wikipedia-org-4107	103	23	blocks	block	VBZ
en-wikipedia-org-4107	103	24	the	the	DT
en-wikipedia-org-4107	103	25	induction	induction	NN
en-wikipedia-org-4107	103	26	of	of	IN
en-wikipedia-org-4107	103	27	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	103	28	-	-	HYPH
en-wikipedia-org-4107	103	29	mediated	mediate	VBN
en-wikipedia-org-4107	103	30	neural	neural	JJ
en-wikipedia-org-4107	103	31	and	and	CC
en-wikipedia-org-4107	103	32	behavioral	behavioral	JJ
en-wikipedia-org-4107	103	33	plasticity	plasticity	NN
en-wikipedia-org-4107	103	34	by	by	IN
en-wikipedia-org-4107	103	35	chronic	chronic	JJ
en-wikipedia-org-4107	103	36	drug	drug	NN
en-wikipedia-org-4107	103	37	use,[sources	use,[sources	NNP
en-wikipedia-org-4107	103	38	11	11	CD
en-wikipedia-org-4107	103	39	]	]	-RRB-
en-wikipedia-org-4107	103	40	which	which	WDT
en-wikipedia-org-4107	103	41	occurs	occur	VBZ
en-wikipedia-org-4107	103	42	via	via	IN
en-wikipedia-org-4107	103	43	H3K9me2-mediated	h3k9me2-mediated	JJ
en-wikipedia-org-4107	103	44	repression	repression	NN
en-wikipedia-org-4107	103	45	of	of	IN
en-wikipedia-org-4107	103	46	transcription	transcription	NN
en-wikipedia-org-4107	103	47	factors	factor	NNS
en-wikipedia-org-4107	103	48	for	for	IN
en-wikipedia-org-4107	103	49	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	103	50	and	and	CC
en-wikipedia-org-4107	103	51	H3K9me2-mediated	h3k9me2-mediated	JJ
en-wikipedia-org-4107	103	52	repression	repression	NN
en-wikipedia-org-4107	103	53	of	of	IN
en-wikipedia-org-4107	103	54	various	various	JJ
en-wikipedia-org-4107	103	55	ΔFosB	δfosb	JJ
en-wikipedia-org-4107	103	56	transcriptional	transcriptional	JJ
en-wikipedia-org-4107	103	57	targets	target	NNS
en-wikipedia-org-4107	103	58	(	(	-LRB-
en-wikipedia-org-4107	103	59	e.g.	e.g.	RB
en-wikipedia-org-4107	103	60	,	,	,
en-wikipedia-org-4107	103	61	CDK5	CDK5	NNP
en-wikipedia-org-4107	103	62	)	)	-RRB-
en-wikipedia-org-4107	103	63	.	.	.
en-wikipedia-org-4107	104	1	[	[	-LRB-
en-wikipedia-org-4107	104	2	109][119][120	109][119][120	CD
en-wikipedia-org-4107	104	3	]	]	-RRB-
en-wikipedia-org-4107	104	4	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	104	5	also	also	RB
en-wikipedia-org-4107	104	6	plays	play	VBZ
en-wikipedia-org-4107	104	7	an	an	DT
en-wikipedia-org-4107	104	8	important	important	JJ
en-wikipedia-org-4107	104	9	role	role	NN
en-wikipedia-org-4107	104	10	in	in	IN
en-wikipedia-org-4107	104	11	regulating	regulate	VBG
en-wikipedia-org-4107	104	12	behavioral	behavioral	JJ
en-wikipedia-org-4107	104	13	responses	response	NNS
en-wikipedia-org-4107	104	14	to	to	IN
en-wikipedia-org-4107	104	15	natural	natural	JJ
en-wikipedia-org-4107	104	16	rewards	reward	NNS
en-wikipedia-org-4107	104	17	,	,	,
en-wikipedia-org-4107	104	18	such	such	JJ
en-wikipedia-org-4107	104	19	as	as	IN
en-wikipedia-org-4107	104	20	palatable	palatable	JJ
en-wikipedia-org-4107	104	21	food	food	NN
en-wikipedia-org-4107	104	22	,	,	,
en-wikipedia-org-4107	104	23	sex	sex	NN
en-wikipedia-org-4107	104	24	,	,	,
en-wikipedia-org-4107	104	25	and	and	CC
en-wikipedia-org-4107	104	26	exercise	exercise	NN
en-wikipedia-org-4107	104	27	.	.	.
en-wikipedia-org-4107	105	1	[	[	-LRB-
en-wikipedia-org-4107	105	2	110][109][123	110][109][123	CD
en-wikipedia-org-4107	105	3	]	]	-RRB-
en-wikipedia-org-4107	105	4	Since	since	IN
en-wikipedia-org-4107	105	5	both	both	DT
en-wikipedia-org-4107	105	6	natural	natural	JJ
en-wikipedia-org-4107	105	7	rewards	reward	NNS
en-wikipedia-org-4107	105	8	and	and	CC
en-wikipedia-org-4107	105	9	addictive	addictive	JJ
en-wikipedia-org-4107	105	10	drugs	drug	NNS
en-wikipedia-org-4107	105	11	induce	induce	VBP
en-wikipedia-org-4107	105	12	the	the	DT
en-wikipedia-org-4107	105	13	expression	expression	NN
en-wikipedia-org-4107	105	14	of	of	IN
en-wikipedia-org-4107	105	15	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	105	16	(	(	-LRB-
en-wikipedia-org-4107	105	17	i.e.	i.e.	FW
en-wikipedia-org-4107	105	18	,	,	,
en-wikipedia-org-4107	105	19	they	-PRON-	PRP
en-wikipedia-org-4107	105	20	cause	cause	VBP
en-wikipedia-org-4107	105	21	the	the	DT
en-wikipedia-org-4107	105	22	brain	brain	NN
en-wikipedia-org-4107	105	23	to	to	TO
en-wikipedia-org-4107	105	24	produce	produce	VB
en-wikipedia-org-4107	105	25	more	more	JJR
en-wikipedia-org-4107	105	26	of	of	IN
en-wikipedia-org-4107	105	27	it	-PRON-	PRP
en-wikipedia-org-4107	105	28	)	)	-RRB-
en-wikipedia-org-4107	105	29	,	,	,
en-wikipedia-org-4107	105	30	chronic	chronic	JJ
en-wikipedia-org-4107	105	31	acquisition	acquisition	NN
en-wikipedia-org-4107	105	32	of	of	IN
en-wikipedia-org-4107	105	33	these	these	DT
en-wikipedia-org-4107	105	34	rewards	reward	NNS
en-wikipedia-org-4107	105	35	can	can	MD
en-wikipedia-org-4107	105	36	result	result	VB
en-wikipedia-org-4107	105	37	in	in	IN
en-wikipedia-org-4107	105	38	a	a	DT
en-wikipedia-org-4107	105	39	similar	similar	JJ
en-wikipedia-org-4107	105	40	pathological	pathological	JJ
en-wikipedia-org-4107	105	41	state	state	NN
en-wikipedia-org-4107	105	42	of	of	IN
en-wikipedia-org-4107	105	43	addiction	addiction	NN
en-wikipedia-org-4107	105	44	.	.	.
en-wikipedia-org-4107	106	1	[	[	-LRB-
en-wikipedia-org-4107	106	2	110][109	110][109	LS
en-wikipedia-org-4107	106	3	]	]	-RRB-
en-wikipedia-org-4107	106	4	Consequently	consequently	RB
en-wikipedia-org-4107	106	5	,	,	,
en-wikipedia-org-4107	106	6	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	106	7	is	be	VBZ
en-wikipedia-org-4107	106	8	the	the	DT
en-wikipedia-org-4107	106	9	most	most	RBS
en-wikipedia-org-4107	106	10	significant	significant	JJ
en-wikipedia-org-4107	106	11	factor	factor	NN
en-wikipedia-org-4107	106	12	involved	involve	VBN
en-wikipedia-org-4107	106	13	in	in	IN
en-wikipedia-org-4107	106	14	both	both	DT
en-wikipedia-org-4107	106	15	amphetamine	amphetamine	NN
en-wikipedia-org-4107	106	16	addiction	addiction	NN
en-wikipedia-org-4107	106	17	and	and	CC
en-wikipedia-org-4107	106	18	amphetamine	amphetamine	NN
en-wikipedia-org-4107	106	19	-	-	HYPH
en-wikipedia-org-4107	106	20	induced	induce	VBN
en-wikipedia-org-4107	106	21	sexual	sexual	JJ
en-wikipedia-org-4107	106	22	addictions	addiction	NNS
en-wikipedia-org-4107	106	23	,	,	,
en-wikipedia-org-4107	106	24	which	which	WDT
en-wikipedia-org-4107	106	25	are	be	VBP
en-wikipedia-org-4107	106	26	compulsive	compulsive	JJ
en-wikipedia-org-4107	106	27	sexual	sexual	JJ
en-wikipedia-org-4107	106	28	behaviors	behavior	NNS
en-wikipedia-org-4107	106	29	that	that	WDT
en-wikipedia-org-4107	106	30	result	result	VBP
en-wikipedia-org-4107	106	31	from	from	IN
en-wikipedia-org-4107	106	32	excessive	excessive	JJ
en-wikipedia-org-4107	106	33	sexual	sexual	JJ
en-wikipedia-org-4107	106	34	activity	activity	NN
en-wikipedia-org-4107	106	35	and	and	CC
en-wikipedia-org-4107	106	36	amphetamine	amphetamine	VB
en-wikipedia-org-4107	106	37	use	use	NN
en-wikipedia-org-4107	106	38	.	.	.
en-wikipedia-org-4107	107	1	[	[	-LRB-
en-wikipedia-org-4107	107	2	110][124][125	110][124][125	LS
en-wikipedia-org-4107	107	3	]	]	-RRB-
en-wikipedia-org-4107	107	4	These	these	DT
en-wikipedia-org-4107	107	5	sexual	sexual	JJ
en-wikipedia-org-4107	107	6	addictions	addiction	NNS
en-wikipedia-org-4107	107	7	are	be	VBP
en-wikipedia-org-4107	107	8	associated	associate	VBN
en-wikipedia-org-4107	107	9	with	with	IN
en-wikipedia-org-4107	107	10	a	a	DT
en-wikipedia-org-4107	107	11	dopamine	dopamine	NN
en-wikipedia-org-4107	107	12	dysregulation	dysregulation	NN
en-wikipedia-org-4107	107	13	syndrome	syndrome	NN
en-wikipedia-org-4107	107	14	which	which	WDT
en-wikipedia-org-4107	107	15	occurs	occur	VBZ
en-wikipedia-org-4107	107	16	in	in	IN
en-wikipedia-org-4107	107	17	some	some	DT
en-wikipedia-org-4107	107	18	patients	patient	NNS
en-wikipedia-org-4107	107	19	taking	take	VBG
en-wikipedia-org-4107	107	20	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	107	21	drugs	drug	NNS
en-wikipedia-org-4107	107	22	.	.	.
en-wikipedia-org-4107	108	1	[	[	-LRB-
en-wikipedia-org-4107	108	2	110][123	110][123	LS
en-wikipedia-org-4107	108	3	]	]	-RRB-
en-wikipedia-org-4107	108	4	The	the	DT
en-wikipedia-org-4107	108	5	effects	effect	NNS
en-wikipedia-org-4107	108	6	of	of	IN
en-wikipedia-org-4107	108	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	108	8	on	on	IN
en-wikipedia-org-4107	108	9	gene	gene	NN
en-wikipedia-org-4107	108	10	regulation	regulation	NN
en-wikipedia-org-4107	108	11	are	be	VBP
en-wikipedia-org-4107	108	12	both	both	DT
en-wikipedia-org-4107	108	13	dose-	dose-	JJ
en-wikipedia-org-4107	108	14	and	and	CC
en-wikipedia-org-4107	108	15	route	route	NN
en-wikipedia-org-4107	108	16	-	-	HYPH
en-wikipedia-org-4107	108	17	dependent	dependent	JJ
en-wikipedia-org-4107	108	18	.	.	.
en-wikipedia-org-4107	109	1	[	[	-LRB-
en-wikipedia-org-4107	109	2	115	115	CD
en-wikipedia-org-4107	109	3	]	]	-RRB-
en-wikipedia-org-4107	109	4	Most	Most	JJS
en-wikipedia-org-4107	109	5	of	of	IN
en-wikipedia-org-4107	109	6	the	the	DT
en-wikipedia-org-4107	109	7	research	research	NN
en-wikipedia-org-4107	109	8	on	on	IN
en-wikipedia-org-4107	109	9	gene	gene	NN
en-wikipedia-org-4107	109	10	regulation	regulation	NN
en-wikipedia-org-4107	109	11	and	and	CC
en-wikipedia-org-4107	109	12	addiction	addiction	NN
en-wikipedia-org-4107	109	13	is	be	VBZ
en-wikipedia-org-4107	109	14	based	base	VBN
en-wikipedia-org-4107	109	15	upon	upon	IN
en-wikipedia-org-4107	109	16	animal	animal	NN
en-wikipedia-org-4107	109	17	studies	study	NNS
en-wikipedia-org-4107	109	18	with	with	IN
en-wikipedia-org-4107	109	19	intravenous	intravenous	JJ
en-wikipedia-org-4107	109	20	amphetamine	amphetamine	NN
en-wikipedia-org-4107	109	21	administration	administration	NN
en-wikipedia-org-4107	109	22	at	at	IN
en-wikipedia-org-4107	109	23	very	very	RB
en-wikipedia-org-4107	109	24	high	high	JJ
en-wikipedia-org-4107	109	25	doses	dose	NNS
en-wikipedia-org-4107	109	26	.	.	.
en-wikipedia-org-4107	110	1	[	[	-LRB-
en-wikipedia-org-4107	110	2	115	115	CD
en-wikipedia-org-4107	110	3	]	]	-RRB-
en-wikipedia-org-4107	110	4	The	the	DT
en-wikipedia-org-4107	110	5	few	few	JJ
en-wikipedia-org-4107	110	6	studies	study	NNS
en-wikipedia-org-4107	110	7	that	that	WDT
en-wikipedia-org-4107	110	8	have	have	VBP
en-wikipedia-org-4107	110	9	used	use	VBN
en-wikipedia-org-4107	110	10	equivalent	equivalent	JJ
en-wikipedia-org-4107	110	11	(	(	-LRB-
en-wikipedia-org-4107	110	12	weight	weight	NN
en-wikipedia-org-4107	110	13	-	-	HYPH
en-wikipedia-org-4107	110	14	adjusted	adjust	VBN
en-wikipedia-org-4107	110	15	)	)	-RRB-
en-wikipedia-org-4107	110	16	human	human	JJ
en-wikipedia-org-4107	110	17	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	110	18	doses	dose	NNS
en-wikipedia-org-4107	110	19	and	and	CC
en-wikipedia-org-4107	110	20	oral	oral	JJ
en-wikipedia-org-4107	110	21	administration	administration	NN
en-wikipedia-org-4107	110	22	show	show	VBP
en-wikipedia-org-4107	110	23	that	that	IN
en-wikipedia-org-4107	110	24	these	these	DT
en-wikipedia-org-4107	110	25	changes	change	NNS
en-wikipedia-org-4107	110	26	,	,	,
en-wikipedia-org-4107	110	27	if	if	IN
en-wikipedia-org-4107	110	28	they	-PRON-	PRP
en-wikipedia-org-4107	110	29	occur	occur	VBP
en-wikipedia-org-4107	110	30	,	,	,
en-wikipedia-org-4107	110	31	are	be	VBP
en-wikipedia-org-4107	110	32	relatively	relatively	RB
en-wikipedia-org-4107	110	33	minor	minor	JJ
en-wikipedia-org-4107	110	34	.	.	.
en-wikipedia-org-4107	111	1	[	[	-LRB-
en-wikipedia-org-4107	111	2	115	115	CD
en-wikipedia-org-4107	111	3	]	]	-RRB-
en-wikipedia-org-4107	111	4	This	this	DT
en-wikipedia-org-4107	111	5	suggests	suggest	VBZ
en-wikipedia-org-4107	111	6	that	that	IN
en-wikipedia-org-4107	111	7	medical	medical	JJ
en-wikipedia-org-4107	111	8	use	use	NN
en-wikipedia-org-4107	111	9	of	of	IN
en-wikipedia-org-4107	111	10	amphetamine	amphetamine	NN
en-wikipedia-org-4107	111	11	does	do	VBZ
en-wikipedia-org-4107	111	12	not	not	RB
en-wikipedia-org-4107	111	13	significantly	significantly	RB
en-wikipedia-org-4107	111	14	affect	affect	VB
en-wikipedia-org-4107	111	15	gene	gene	NN
en-wikipedia-org-4107	111	16	regulation	regulation	NN
en-wikipedia-org-4107	111	17	.	.	.
en-wikipedia-org-4107	112	1	[	[	-LRB-
en-wikipedia-org-4107	112	2	115	115	CD
en-wikipedia-org-4107	112	3	]	]	-RRB-
en-wikipedia-org-4107	112	4	Pharmacological	pharmacological	JJ
en-wikipedia-org-4107	112	5	treatments	treatment	NNS
en-wikipedia-org-4107	112	6	Further	further	JJ
en-wikipedia-org-4107	112	7	information	information	NN
en-wikipedia-org-4107	112	8	:	:	:
en-wikipedia-org-4107	112	9	Addiction	addiction	NN
en-wikipedia-org-4107	112	10	§	§	-LRB-
en-wikipedia-org-4107	112	11	 	  	_SP
en-wikipedia-org-4107	112	12	Research	Research	NNP
en-wikipedia-org-4107	112	13	As	as	IN
en-wikipedia-org-4107	112	14	of	of	IN
en-wikipedia-org-4107	112	15	December	December	NNP
en-wikipedia-org-4107	112	16	2019,[update	2019,[update	NN
en-wikipedia-org-4107	112	17	]	]	-RRB-
en-wikipedia-org-4107	112	18	there	there	EX
en-wikipedia-org-4107	112	19	is	be	VBZ
en-wikipedia-org-4107	112	20	no	no	DT
en-wikipedia-org-4107	112	21	effective	effective	JJ
en-wikipedia-org-4107	112	22	pharmacotherapy	pharmacotherapy	NN
en-wikipedia-org-4107	112	23	for	for	IN
en-wikipedia-org-4107	112	24	amphetamine	amphetamine	NN
en-wikipedia-org-4107	112	25	addiction	addiction	NN
en-wikipedia-org-4107	112	26	.	.	.
en-wikipedia-org-4107	113	1	[	[	-LRB-
en-wikipedia-org-4107	113	2	126][127][128	126][127][128	CD
en-wikipedia-org-4107	113	3	]	]	-RRB-
en-wikipedia-org-4107	113	4	Reviews	review	NNS
en-wikipedia-org-4107	113	5	from	from	IN
en-wikipedia-org-4107	113	6	2015	2015	CD
en-wikipedia-org-4107	113	7	and	and	CC
en-wikipedia-org-4107	113	8	2016	2016	CD
en-wikipedia-org-4107	113	9	indicated	indicate	VBD
en-wikipedia-org-4107	113	10	that	that	IN
en-wikipedia-org-4107	113	11	TAAR1-selective	TAAR1-selective	NNP
en-wikipedia-org-4107	113	12	agonists	agonist	NNS
en-wikipedia-org-4107	113	13	have	have	VBP
en-wikipedia-org-4107	113	14	significant	significant	JJ
en-wikipedia-org-4107	113	15	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	113	16	potential	potential	NN
en-wikipedia-org-4107	113	17	as	as	IN
en-wikipedia-org-4107	113	18	a	a	DT
en-wikipedia-org-4107	113	19	treatment	treatment	NN
en-wikipedia-org-4107	113	20	for	for	IN
en-wikipedia-org-4107	113	21	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	113	22	addictions;[38][129	addictions;[38][129	CD
en-wikipedia-org-4107	113	23	]	]	-RRB-
en-wikipedia-org-4107	113	24	however	however	RB
en-wikipedia-org-4107	113	25	,	,	,
en-wikipedia-org-4107	113	26	as	as	IN
en-wikipedia-org-4107	113	27	of	of	IN
en-wikipedia-org-4107	113	28	February	February	NNP
en-wikipedia-org-4107	113	29	2016,[update	2016,[update	NN
en-wikipedia-org-4107	113	30	]	]	-RRB-
en-wikipedia-org-4107	113	31	the	the	DT
en-wikipedia-org-4107	113	32	only	only	JJ
en-wikipedia-org-4107	113	33	compounds	compound	NNS
en-wikipedia-org-4107	113	34	which	which	WDT
en-wikipedia-org-4107	113	35	are	be	VBP
en-wikipedia-org-4107	113	36	known	know	VBN
en-wikipedia-org-4107	113	37	to	to	TO
en-wikipedia-org-4107	113	38	function	function	VB
en-wikipedia-org-4107	113	39	as	as	IN
en-wikipedia-org-4107	113	40	TAAR1-selective	taar1-selective	JJ
en-wikipedia-org-4107	113	41	agonists	agonist	NNS
en-wikipedia-org-4107	113	42	are	be	VBP
en-wikipedia-org-4107	113	43	experimental	experimental	JJ
en-wikipedia-org-4107	113	44	drugs	drug	NNS
en-wikipedia-org-4107	113	45	.	.	.
en-wikipedia-org-4107	114	1	[	[	-LRB-
en-wikipedia-org-4107	114	2	38][129	38][129	FW
en-wikipedia-org-4107	114	3	]	]	-RRB-
en-wikipedia-org-4107	114	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	114	5	addiction	addiction	NN
en-wikipedia-org-4107	114	6	is	be	VBZ
en-wikipedia-org-4107	114	7	largely	largely	RB
en-wikipedia-org-4107	114	8	mediated	mediate	VBN
en-wikipedia-org-4107	114	9	through	through	IN
en-wikipedia-org-4107	114	10	increased	increase	VBN
en-wikipedia-org-4107	114	11	activation	activation	NN
en-wikipedia-org-4107	114	12	of	of	IN
en-wikipedia-org-4107	114	13	dopamine	dopamine	NN
en-wikipedia-org-4107	114	14	receptors	receptor	NNS
en-wikipedia-org-4107	114	15	and	and	CC
en-wikipedia-org-4107	114	16	co	co	JJ
en-wikipedia-org-4107	114	17	-	-	JJ
en-wikipedia-org-4107	114	18	localized	localized	JJ
en-wikipedia-org-4107	114	19	NMDA	NMDA	NNP
en-wikipedia-org-4107	114	20	receptors[note	receptors[note	NNP
en-wikipedia-org-4107	114	21	13	13	CD
en-wikipedia-org-4107	114	22	]	]	-RRB-
en-wikipedia-org-4107	114	23	in	in	IN
en-wikipedia-org-4107	114	24	the	the	DT
en-wikipedia-org-4107	114	25	nucleus	nucleus	NN
en-wikipedia-org-4107	114	26	accumbens;[107	accumbens;[107	JJ
en-wikipedia-org-4107	114	27	]	]	-RRB-
en-wikipedia-org-4107	114	28	magnesium	magnesium	JJ
en-wikipedia-org-4107	114	29	ions	ion	NNS
en-wikipedia-org-4107	114	30	inhibit	inhibit	VBP
en-wikipedia-org-4107	114	31	NMDA	NMDA	NNP
en-wikipedia-org-4107	114	32	receptors	receptor	NNS
en-wikipedia-org-4107	114	33	by	by	IN
en-wikipedia-org-4107	114	34	blocking	block	VBG
en-wikipedia-org-4107	114	35	the	the	DT
en-wikipedia-org-4107	114	36	receptor	receptor	NNP
en-wikipedia-org-4107	114	37	calcium	calcium	NN
en-wikipedia-org-4107	114	38	channel	channel	NNP
en-wikipedia-org-4107	114	39	.	.	.
en-wikipedia-org-4107	115	1	[	[	-LRB-
en-wikipedia-org-4107	115	2	107][130	107][130	CD
en-wikipedia-org-4107	115	3	]	]	-RRB-
en-wikipedia-org-4107	115	4	One	one	CD
en-wikipedia-org-4107	115	5	review	review	NN
en-wikipedia-org-4107	115	6	suggested	suggest	VBD
en-wikipedia-org-4107	115	7	that	that	IN
en-wikipedia-org-4107	115	8	,	,	,
en-wikipedia-org-4107	115	9	based	base	VBN
en-wikipedia-org-4107	115	10	upon	upon	IN
en-wikipedia-org-4107	115	11	animal	animal	NN
en-wikipedia-org-4107	115	12	testing	testing	NN
en-wikipedia-org-4107	115	13	,	,	,
en-wikipedia-org-4107	115	14	pathological	pathological	JJ
en-wikipedia-org-4107	115	15	(	(	-LRB-
en-wikipedia-org-4107	115	16	addiction	addiction	NN
en-wikipedia-org-4107	115	17	-	-	HYPH
en-wikipedia-org-4107	115	18	inducing	induce	VBG
en-wikipedia-org-4107	115	19	)	)	-RRB-
en-wikipedia-org-4107	115	20	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	115	21	use	use	NN
en-wikipedia-org-4107	115	22	significantly	significantly	RB
en-wikipedia-org-4107	115	23	reduces	reduce	VBZ
en-wikipedia-org-4107	115	24	the	the	DT
en-wikipedia-org-4107	115	25	level	level	NN
en-wikipedia-org-4107	115	26	of	of	IN
en-wikipedia-org-4107	115	27	intracellular	intracellular	JJ
en-wikipedia-org-4107	115	28	magnesium	magnesium	NN
en-wikipedia-org-4107	115	29	throughout	throughout	IN
en-wikipedia-org-4107	115	30	the	the	DT
en-wikipedia-org-4107	115	31	brain	brain	NN
en-wikipedia-org-4107	115	32	.	.	.
en-wikipedia-org-4107	116	1	[	[	-LRB-
en-wikipedia-org-4107	116	2	107	107	CD
en-wikipedia-org-4107	116	3	]	]	-RRB-
en-wikipedia-org-4107	116	4	Supplemental	Supplemental	NNP
en-wikipedia-org-4107	116	5	magnesium[note	magnesium[note	CD
en-wikipedia-org-4107	116	6	14	14	CD
en-wikipedia-org-4107	116	7	]	]	-RRB-
en-wikipedia-org-4107	116	8	treatment	treatment	NN
en-wikipedia-org-4107	116	9	has	have	VBZ
en-wikipedia-org-4107	116	10	been	be	VBN
en-wikipedia-org-4107	116	11	shown	show	VBN
en-wikipedia-org-4107	116	12	to	to	TO
en-wikipedia-org-4107	116	13	reduce	reduce	VB
en-wikipedia-org-4107	116	14	amphetamine	amphetamine	NN
en-wikipedia-org-4107	116	15	self	self	NN
en-wikipedia-org-4107	116	16	-	-	HYPH
en-wikipedia-org-4107	116	17	administration	administration	NN
en-wikipedia-org-4107	116	18	(	(	-LRB-
en-wikipedia-org-4107	116	19	i.e.	i.e.	FW
en-wikipedia-org-4107	116	20	,	,	,
en-wikipedia-org-4107	116	21	doses	dose	NNS
en-wikipedia-org-4107	116	22	given	give	VBN
en-wikipedia-org-4107	116	23	to	to	IN
en-wikipedia-org-4107	116	24	oneself	oneself	PRP
en-wikipedia-org-4107	116	25	)	)	-RRB-
en-wikipedia-org-4107	116	26	in	in	IN
en-wikipedia-org-4107	116	27	humans	human	NNS
en-wikipedia-org-4107	116	28	,	,	,
en-wikipedia-org-4107	116	29	but	but	CC
en-wikipedia-org-4107	116	30	it	-PRON-	PRP
en-wikipedia-org-4107	116	31	is	be	VBZ
en-wikipedia-org-4107	116	32	not	not	RB
en-wikipedia-org-4107	116	33	an	an	DT
en-wikipedia-org-4107	116	34	effective	effective	JJ
en-wikipedia-org-4107	116	35	monotherapy	monotherapy	NN
en-wikipedia-org-4107	116	36	for	for	IN
en-wikipedia-org-4107	116	37	amphetamine	amphetamine	NN
en-wikipedia-org-4107	116	38	addiction	addiction	NN
en-wikipedia-org-4107	116	39	.	.	.
en-wikipedia-org-4107	117	1	[	[	-LRB-
en-wikipedia-org-4107	117	2	107	107	CD
en-wikipedia-org-4107	117	3	]	]	-RRB-
en-wikipedia-org-4107	117	4	A	a	DT
en-wikipedia-org-4107	117	5	systematic	systematic	JJ
en-wikipedia-org-4107	117	6	review	review	NN
en-wikipedia-org-4107	117	7	and	and	CC
en-wikipedia-org-4107	117	8	meta	meta	JJ
en-wikipedia-org-4107	117	9	-	-	HYPH
en-wikipedia-org-4107	117	10	analysis	analysis	NN
en-wikipedia-org-4107	117	11	from	from	IN
en-wikipedia-org-4107	117	12	2019	2019	CD
en-wikipedia-org-4107	117	13	assessed	assess	VBD
en-wikipedia-org-4107	117	14	the	the	DT
en-wikipedia-org-4107	117	15	efficacy	efficacy	NN
en-wikipedia-org-4107	117	16	of	of	IN
en-wikipedia-org-4107	117	17	17	17	CD
en-wikipedia-org-4107	117	18	different	different	JJ
en-wikipedia-org-4107	117	19	pharmacotherapies	pharmacotherapie	NNS
en-wikipedia-org-4107	117	20	used	use	VBN
en-wikipedia-org-4107	117	21	in	in	IN
en-wikipedia-org-4107	117	22	RCTs	RCTs	NNP
en-wikipedia-org-4107	117	23	for	for	IN
en-wikipedia-org-4107	117	24	amphetamine	amphetamine	NN
en-wikipedia-org-4107	117	25	and	and	CC
en-wikipedia-org-4107	117	26	methamphetamine	methamphetamine	PRP$
en-wikipedia-org-4107	117	27	addiction;[127	addiction;[127	NNPS
en-wikipedia-org-4107	117	28	]	]	-RRB-
en-wikipedia-org-4107	117	29	it	-PRON-	PRP
en-wikipedia-org-4107	117	30	found	find	VBD
en-wikipedia-org-4107	117	31	only	only	RB
en-wikipedia-org-4107	117	32	low	low	JJ
en-wikipedia-org-4107	117	33	-	-	HYPH
en-wikipedia-org-4107	117	34	strength	strength	NN
en-wikipedia-org-4107	117	35	evidence	evidence	NN
en-wikipedia-org-4107	117	36	that	that	IN
en-wikipedia-org-4107	117	37	methylphenidate	methylphenidate	NN
en-wikipedia-org-4107	117	38	might	may	MD
en-wikipedia-org-4107	117	39	reduce	reduce	VB
en-wikipedia-org-4107	117	40	amphetamine	amphetamine	NN
en-wikipedia-org-4107	117	41	or	or	CC
en-wikipedia-org-4107	117	42	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	117	43	self	self	NN
en-wikipedia-org-4107	117	44	-	-	HYPH
en-wikipedia-org-4107	117	45	administration	administration	NN
en-wikipedia-org-4107	117	46	.	.	.
en-wikipedia-org-4107	118	1	[	[	-LRB-
en-wikipedia-org-4107	118	2	127	127	CD
en-wikipedia-org-4107	118	3	]	]	-RRB-
en-wikipedia-org-4107	118	4	There	there	EX
en-wikipedia-org-4107	118	5	was	be	VBD
en-wikipedia-org-4107	118	6	low-	low-	NN
en-wikipedia-org-4107	118	7	to	to	IN
en-wikipedia-org-4107	118	8	moderate	moderate	JJ
en-wikipedia-org-4107	118	9	-	-	HYPH
en-wikipedia-org-4107	118	10	strength	strength	NN
en-wikipedia-org-4107	118	11	evidence	evidence	NN
en-wikipedia-org-4107	118	12	of	of	IN
en-wikipedia-org-4107	118	13	no	no	DT
en-wikipedia-org-4107	118	14	benefit	benefit	NN
en-wikipedia-org-4107	118	15	for	for	IN
en-wikipedia-org-4107	118	16	most	most	JJS
en-wikipedia-org-4107	118	17	of	of	IN
en-wikipedia-org-4107	118	18	the	the	DT
en-wikipedia-org-4107	118	19	other	other	JJ
en-wikipedia-org-4107	118	20	medications	medication	NNS
en-wikipedia-org-4107	118	21	used	use	VBN
en-wikipedia-org-4107	118	22	in	in	IN
en-wikipedia-org-4107	118	23	RCTs	RCTs	NNP
en-wikipedia-org-4107	118	24	,	,	,
en-wikipedia-org-4107	118	25	which	which	WDT
en-wikipedia-org-4107	118	26	included	include	VBD
en-wikipedia-org-4107	118	27	antidepressants	antidepressant	NNS
en-wikipedia-org-4107	118	28	(	(	-LRB-
en-wikipedia-org-4107	118	29	bupropion	bupropion	NN
en-wikipedia-org-4107	118	30	,	,	,
en-wikipedia-org-4107	118	31	mirtazapine	mirtazapine	NN
en-wikipedia-org-4107	118	32	,	,	,
en-wikipedia-org-4107	118	33	sertraline	sertraline	NN
en-wikipedia-org-4107	118	34	)	)	-RRB-
en-wikipedia-org-4107	118	35	,	,	,
en-wikipedia-org-4107	118	36	antipsychotics	antipsychotics	NNP
en-wikipedia-org-4107	118	37	(	(	-LRB-
en-wikipedia-org-4107	118	38	aripiprazole	aripiprazole	NNP
en-wikipedia-org-4107	118	39	)	)	-RRB-
en-wikipedia-org-4107	118	40	,	,	,
en-wikipedia-org-4107	118	41	anticonvulsants	anticonvulsant	NNS
en-wikipedia-org-4107	118	42	(	(	-LRB-
en-wikipedia-org-4107	118	43	topiramate	topiramate	NNP
en-wikipedia-org-4107	118	44	,	,	,
en-wikipedia-org-4107	118	45	baclofen	baclofen	NNP
en-wikipedia-org-4107	118	46	,	,	,
en-wikipedia-org-4107	118	47	gabapentin	gabapentin	NNP
en-wikipedia-org-4107	118	48	)	)	-RRB-
en-wikipedia-org-4107	118	49	,	,	,
en-wikipedia-org-4107	118	50	naltrexone	naltrexone	NN
en-wikipedia-org-4107	118	51	,	,	,
en-wikipedia-org-4107	118	52	varenicline	varenicline	NN
en-wikipedia-org-4107	118	53	,	,	,
en-wikipedia-org-4107	118	54	citicoline	citicoline	NN
en-wikipedia-org-4107	118	55	,	,	,
en-wikipedia-org-4107	118	56	ondansetron	ondansetron	NNP
en-wikipedia-org-4107	118	57	,	,	,
en-wikipedia-org-4107	118	58	prometa	prometa	NN
en-wikipedia-org-4107	118	59	,	,	,
en-wikipedia-org-4107	118	60	riluzole	riluzole	NN
en-wikipedia-org-4107	118	61	,	,	,
en-wikipedia-org-4107	118	62	atomoxetine	atomoxetine	NN
en-wikipedia-org-4107	118	63	,	,	,
en-wikipedia-org-4107	118	64	dextroamphetamine	dextroamphetamine	JJ
en-wikipedia-org-4107	118	65	,	,	,
en-wikipedia-org-4107	118	66	and	and	CC
en-wikipedia-org-4107	118	67	modafinil	modafinil	NN
en-wikipedia-org-4107	118	68	.	.	.
en-wikipedia-org-4107	119	1	[	[	-LRB-
en-wikipedia-org-4107	119	2	127	127	CD
en-wikipedia-org-4107	119	3	]	]	-RRB-
en-wikipedia-org-4107	119	4	Behavioral	behavioral	JJ
en-wikipedia-org-4107	119	5	treatments	treatment	NNS
en-wikipedia-org-4107	119	6	A	a	DT
en-wikipedia-org-4107	119	7	2018	2018	CD
en-wikipedia-org-4107	119	8	systematic	systematic	JJ
en-wikipedia-org-4107	119	9	review	review	NN
en-wikipedia-org-4107	119	10	and	and	CC
en-wikipedia-org-4107	119	11	network	network	NN
en-wikipedia-org-4107	119	12	meta	meta	JJ
en-wikipedia-org-4107	119	13	-	-	HYPH
en-wikipedia-org-4107	119	14	analysis	analysis	NN
en-wikipedia-org-4107	119	15	of	of	IN
en-wikipedia-org-4107	119	16	50	50	CD
en-wikipedia-org-4107	119	17	trials	trial	NNS
en-wikipedia-org-4107	119	18	involving	involve	VBG
en-wikipedia-org-4107	119	19	12	12	CD
en-wikipedia-org-4107	119	20	different	different	JJ
en-wikipedia-org-4107	119	21	psychosocial	psychosocial	JJ
en-wikipedia-org-4107	119	22	interventions	intervention	NNS
en-wikipedia-org-4107	119	23	for	for	IN
en-wikipedia-org-4107	119	24	amphetamine	amphetamine	NN
en-wikipedia-org-4107	119	25	,	,	,
en-wikipedia-org-4107	119	26	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	119	27	,	,	,
en-wikipedia-org-4107	119	28	or	or	CC
en-wikipedia-org-4107	119	29	cocaine	cocaine	NN
en-wikipedia-org-4107	119	30	addiction	addiction	NN
en-wikipedia-org-4107	119	31	found	find	VBD
en-wikipedia-org-4107	119	32	that	that	IN
en-wikipedia-org-4107	119	33	combination	combination	NN
en-wikipedia-org-4107	119	34	therapy	therapy	NN
en-wikipedia-org-4107	119	35	with	with	IN
en-wikipedia-org-4107	119	36	both	both	CC
en-wikipedia-org-4107	119	37	contingency	contingency	NN
en-wikipedia-org-4107	119	38	management	management	NN
en-wikipedia-org-4107	119	39	and	and	CC
en-wikipedia-org-4107	119	40	community	community	NN
en-wikipedia-org-4107	119	41	reinforcement	reinforcement	NN
en-wikipedia-org-4107	119	42	approach	approach	NN
en-wikipedia-org-4107	119	43	had	have	VBD
en-wikipedia-org-4107	119	44	the	the	DT
en-wikipedia-org-4107	119	45	highest	high	JJS
en-wikipedia-org-4107	119	46	efficacy	efficacy	NN
en-wikipedia-org-4107	119	47	(	(	-LRB-
en-wikipedia-org-4107	119	48	i.e.	i.e.	FW
en-wikipedia-org-4107	119	49	,	,	,
en-wikipedia-org-4107	119	50	abstinence	abstinence	NN
en-wikipedia-org-4107	119	51	rate	rate	NN
en-wikipedia-org-4107	119	52	)	)	-RRB-
en-wikipedia-org-4107	119	53	and	and	CC
en-wikipedia-org-4107	119	54	acceptability	acceptability	NN
en-wikipedia-org-4107	119	55	(	(	-LRB-
en-wikipedia-org-4107	119	56	i.e.	i.e.	FW
en-wikipedia-org-4107	119	57	,	,	,
en-wikipedia-org-4107	119	58	lowest	low	JJS
en-wikipedia-org-4107	119	59	dropout	dropout	NN
en-wikipedia-org-4107	119	60	rate	rate	NN
en-wikipedia-org-4107	119	61	)	)	-RRB-
en-wikipedia-org-4107	119	62	.	.	.
en-wikipedia-org-4107	120	1	[	[	-LRB-
en-wikipedia-org-4107	120	2	131	131	CD
en-wikipedia-org-4107	120	3	]	]	-RRB-
en-wikipedia-org-4107	120	4	Other	other	JJ
en-wikipedia-org-4107	120	5	treatment	treatment	NN
en-wikipedia-org-4107	120	6	modalities	modality	NNS
en-wikipedia-org-4107	120	7	examined	examine	VBN
en-wikipedia-org-4107	120	8	in	in	IN
en-wikipedia-org-4107	120	9	the	the	DT
en-wikipedia-org-4107	120	10	analysis	analysis	NN
en-wikipedia-org-4107	120	11	included	include	VBD
en-wikipedia-org-4107	120	12	monotherapy	monotherapy	NN
en-wikipedia-org-4107	120	13	with	with	IN
en-wikipedia-org-4107	120	14	contingency	contingency	NN
en-wikipedia-org-4107	120	15	management	management	NN
en-wikipedia-org-4107	120	16	or	or	CC
en-wikipedia-org-4107	120	17	community	community	NN
en-wikipedia-org-4107	120	18	reinforcement	reinforcement	NN
en-wikipedia-org-4107	120	19	approach	approach	NN
en-wikipedia-org-4107	120	20	,	,	,
en-wikipedia-org-4107	120	21	cognitive	cognitive	JJ
en-wikipedia-org-4107	120	22	behavioral	behavioral	JJ
en-wikipedia-org-4107	120	23	therapy	therapy	NN
en-wikipedia-org-4107	120	24	,	,	,
en-wikipedia-org-4107	120	25	12-step	12-step	CD
en-wikipedia-org-4107	120	26	programs	program	NNS
en-wikipedia-org-4107	120	27	,	,	,
en-wikipedia-org-4107	120	28	non	non	JJ
en-wikipedia-org-4107	120	29	-	-	JJ
en-wikipedia-org-4107	120	30	contingent	contingent	JJ
en-wikipedia-org-4107	120	31	reward	reward	NN
en-wikipedia-org-4107	120	32	-	-	HYPH
en-wikipedia-org-4107	120	33	based	base	VBN
en-wikipedia-org-4107	120	34	therapies	therapy	NNS
en-wikipedia-org-4107	120	35	,	,	,
en-wikipedia-org-4107	120	36	psychodynamic	psychodynamic	JJ
en-wikipedia-org-4107	120	37	therapy	therapy	NN
en-wikipedia-org-4107	120	38	,	,	,
en-wikipedia-org-4107	120	39	and	and	CC
en-wikipedia-org-4107	120	40	other	other	JJ
en-wikipedia-org-4107	120	41	combination	combination	NN
en-wikipedia-org-4107	120	42	therapies	therapy	NNS
en-wikipedia-org-4107	120	43	involving	involve	VBG
en-wikipedia-org-4107	120	44	these	these	DT
en-wikipedia-org-4107	120	45	.	.	.
en-wikipedia-org-4107	121	1	[	[	-LRB-
en-wikipedia-org-4107	121	2	131	131	CD
en-wikipedia-org-4107	121	3	]	]	-RRB-
en-wikipedia-org-4107	121	4	Additionally	additionally	RB
en-wikipedia-org-4107	121	5	,	,	,
en-wikipedia-org-4107	121	6	research	research	NN
en-wikipedia-org-4107	121	7	on	on	IN
en-wikipedia-org-4107	121	8	the	the	DT
en-wikipedia-org-4107	121	9	neurobiological	neurobiological	JJ
en-wikipedia-org-4107	121	10	effects	effect	NNS
en-wikipedia-org-4107	121	11	of	of	IN
en-wikipedia-org-4107	121	12	physical	physical	JJ
en-wikipedia-org-4107	121	13	exercise	exercise	NN
en-wikipedia-org-4107	121	14	suggests	suggest	VBZ
en-wikipedia-org-4107	121	15	that	that	IN
en-wikipedia-org-4107	121	16	daily	daily	JJ
en-wikipedia-org-4107	121	17	aerobic	aerobic	JJ
en-wikipedia-org-4107	121	18	exercise	exercise	NN
en-wikipedia-org-4107	121	19	,	,	,
en-wikipedia-org-4107	121	20	especially	especially	RB
en-wikipedia-org-4107	121	21	endurance	endurance	NN
en-wikipedia-org-4107	121	22	exercise	exercise	NN
en-wikipedia-org-4107	121	23	(	(	-LRB-
en-wikipedia-org-4107	121	24	e.g.	e.g.	RB
en-wikipedia-org-4107	121	25	,	,	,
en-wikipedia-org-4107	121	26	marathon	marathon	NN
en-wikipedia-org-4107	121	27	running	running	NN
en-wikipedia-org-4107	121	28	)	)	-RRB-
en-wikipedia-org-4107	121	29	,	,	,
en-wikipedia-org-4107	121	30	prevents	prevent	VBZ
en-wikipedia-org-4107	121	31	the	the	DT
en-wikipedia-org-4107	121	32	development	development	NN
en-wikipedia-org-4107	121	33	of	of	IN
en-wikipedia-org-4107	121	34	drug	drug	NN
en-wikipedia-org-4107	121	35	addiction	addiction	NN
en-wikipedia-org-4107	121	36	and	and	CC
en-wikipedia-org-4107	121	37	is	be	VBZ
en-wikipedia-org-4107	121	38	an	an	DT
en-wikipedia-org-4107	121	39	effective	effective	JJ
en-wikipedia-org-4107	121	40	adjunct	adjunct	JJ
en-wikipedia-org-4107	121	41	therapy	therapy	NN
en-wikipedia-org-4107	121	42	(	(	-LRB-
en-wikipedia-org-4107	121	43	i.e.	i.e.	FW
en-wikipedia-org-4107	121	44	,	,	,
en-wikipedia-org-4107	121	45	a	a	DT
en-wikipedia-org-4107	121	46	supplemental	supplemental	JJ
en-wikipedia-org-4107	121	47	treatment	treatment	NN
en-wikipedia-org-4107	121	48	)	)	-RRB-
en-wikipedia-org-4107	121	49	for	for	IN
en-wikipedia-org-4107	121	50	amphetamine	amphetamine	NN
en-wikipedia-org-4107	121	51	addiction	addiction	NN
en-wikipedia-org-4107	121	52	.	.	.
en-wikipedia-org-4107	122	1	[	[	-LRB-
en-wikipedia-org-4107	122	2	sources	source	NNS
en-wikipedia-org-4107	122	3	9	9	CD
en-wikipedia-org-4107	122	4	]	]	-RRB-
en-wikipedia-org-4107	122	5	Exercise	exercise	NN
en-wikipedia-org-4107	122	6	leads	lead	VBZ
en-wikipedia-org-4107	122	7	to	to	IN
en-wikipedia-org-4107	122	8	better	well	JJR
en-wikipedia-org-4107	122	9	treatment	treatment	NN
en-wikipedia-org-4107	122	10	outcomes	outcome	NNS
en-wikipedia-org-4107	122	11	when	when	WRB
en-wikipedia-org-4107	122	12	used	use	VBN
en-wikipedia-org-4107	122	13	as	as	IN
en-wikipedia-org-4107	122	14	an	an	DT
en-wikipedia-org-4107	122	15	adjunct	adjunct	JJ
en-wikipedia-org-4107	122	16	treatment	treatment	NN
en-wikipedia-org-4107	122	17	,	,	,
en-wikipedia-org-4107	122	18	particularly	particularly	RB
en-wikipedia-org-4107	122	19	for	for	IN
en-wikipedia-org-4107	122	20	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	122	21	addictions	addiction	NNS
en-wikipedia-org-4107	122	22	.	.	.
en-wikipedia-org-4107	123	1	[	[	-LRB-
en-wikipedia-org-4107	123	2	111][113][132	111][113][132	CD
en-wikipedia-org-4107	123	3	]	]	-RRB-
en-wikipedia-org-4107	123	4	In	in	IN
en-wikipedia-org-4107	123	5	particular	particular	JJ
en-wikipedia-org-4107	123	6	,	,	,
en-wikipedia-org-4107	123	7	aerobic	aerobic	JJ
en-wikipedia-org-4107	123	8	exercise	exercise	NN
en-wikipedia-org-4107	123	9	decreases	decrease	VBZ
en-wikipedia-org-4107	123	10	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	123	11	self	self	NN
en-wikipedia-org-4107	123	12	-	-	HYPH
en-wikipedia-org-4107	123	13	administration	administration	NN
en-wikipedia-org-4107	123	14	,	,	,
en-wikipedia-org-4107	123	15	reduces	reduce	VBZ
en-wikipedia-org-4107	123	16	the	the	DT
en-wikipedia-org-4107	123	17	reinstatement	reinstatement	NN
en-wikipedia-org-4107	123	18	(	(	-LRB-
en-wikipedia-org-4107	123	19	i.e.	i.e.	FW
en-wikipedia-org-4107	123	20	,	,	,
en-wikipedia-org-4107	123	21	relapse	relapse	VBP
en-wikipedia-org-4107	123	22	)	)	-RRB-
en-wikipedia-org-4107	123	23	of	of	IN
en-wikipedia-org-4107	123	24	drug	drug	NN
en-wikipedia-org-4107	123	25	-	-	HYPH
en-wikipedia-org-4107	123	26	seeking	seeking	NN
en-wikipedia-org-4107	123	27	,	,	,
en-wikipedia-org-4107	123	28	and	and	CC
en-wikipedia-org-4107	123	29	induces	induce	VBZ
en-wikipedia-org-4107	123	30	increased	increase	VBD
en-wikipedia-org-4107	123	31	dopamine	dopamine	NN
en-wikipedia-org-4107	123	32	receptor	receptor	NN
en-wikipedia-org-4107	123	33	D2	D2	NNP
en-wikipedia-org-4107	123	34	(	(	-LRB-
en-wikipedia-org-4107	123	35	DRD2	DRD2	NNP
en-wikipedia-org-4107	123	36	)	)	-RRB-
en-wikipedia-org-4107	123	37	density	density	NN
en-wikipedia-org-4107	123	38	in	in	IN
en-wikipedia-org-4107	123	39	the	the	DT
en-wikipedia-org-4107	123	40	striatum	striatum	NN
en-wikipedia-org-4107	123	41	.	.	.
en-wikipedia-org-4107	124	1	[	[	-LRB-
en-wikipedia-org-4107	124	2	110][132	110][132	CD
en-wikipedia-org-4107	124	3	]	]	-RRB-
en-wikipedia-org-4107	124	4	This	this	DT
en-wikipedia-org-4107	124	5	is	be	VBZ
en-wikipedia-org-4107	124	6	the	the	DT
en-wikipedia-org-4107	124	7	opposite	opposite	NN
en-wikipedia-org-4107	124	8	of	of	IN
en-wikipedia-org-4107	124	9	pathological	pathological	JJ
en-wikipedia-org-4107	124	10	stimulant	stimulant	NN
en-wikipedia-org-4107	124	11	use	use	NN
en-wikipedia-org-4107	124	12	,	,	,
en-wikipedia-org-4107	124	13	which	which	WDT
en-wikipedia-org-4107	124	14	induces	induce	VBZ
en-wikipedia-org-4107	124	15	decreased	decrease	VBD
en-wikipedia-org-4107	124	16	striatal	striatal	JJ
en-wikipedia-org-4107	124	17	DRD2	DRD2	NNP
en-wikipedia-org-4107	124	18	density	density	NN
en-wikipedia-org-4107	124	19	.	.	.
en-wikipedia-org-4107	125	1	[	[	-LRB-
en-wikipedia-org-4107	125	2	110	110	CD
en-wikipedia-org-4107	125	3	]	]	-RRB-
en-wikipedia-org-4107	125	4	One	one	CD
en-wikipedia-org-4107	125	5	review	review	NN
en-wikipedia-org-4107	125	6	noted	note	VBD
en-wikipedia-org-4107	125	7	that	that	IN
en-wikipedia-org-4107	125	8	exercise	exercise	NN
en-wikipedia-org-4107	125	9	may	may	MD
en-wikipedia-org-4107	125	10	also	also	RB
en-wikipedia-org-4107	125	11	prevent	prevent	VB
en-wikipedia-org-4107	125	12	the	the	DT
en-wikipedia-org-4107	125	13	development	development	NN
en-wikipedia-org-4107	125	14	of	of	IN
en-wikipedia-org-4107	125	15	a	a	DT
en-wikipedia-org-4107	125	16	drug	drug	NN
en-wikipedia-org-4107	125	17	addiction	addiction	NN
en-wikipedia-org-4107	125	18	by	by	IN
en-wikipedia-org-4107	125	19	altering	alter	VBG
en-wikipedia-org-4107	125	20	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	125	21	or	or	CC
en-wikipedia-org-4107	125	22	c	c	NNP
en-wikipedia-org-4107	125	23	-	-	:
en-wikipedia-org-4107	125	24	Fos	Fos	NNP
en-wikipedia-org-4107	125	25	immunoreactivity	immunoreactivity	NN
en-wikipedia-org-4107	125	26	in	in	IN
en-wikipedia-org-4107	125	27	the	the	DT
en-wikipedia-org-4107	125	28	striatum	striatum	NN
en-wikipedia-org-4107	125	29	or	or	CC
en-wikipedia-org-4107	125	30	other	other	JJ
en-wikipedia-org-4107	125	31	parts	part	NNS
en-wikipedia-org-4107	125	32	of	of	IN
en-wikipedia-org-4107	125	33	the	the	DT
en-wikipedia-org-4107	125	34	reward	reward	NN
en-wikipedia-org-4107	125	35	system	system	NN
en-wikipedia-org-4107	125	36	.	.	.
en-wikipedia-org-4107	126	1	[	[	-LRB-
en-wikipedia-org-4107	126	2	112	112	CD
en-wikipedia-org-4107	126	3	]	]	-RRB-
en-wikipedia-org-4107	126	4	Summary	Summary	NNP
en-wikipedia-org-4107	126	5	of	of	IN
en-wikipedia-org-4107	126	6	addiction	addiction	NN
en-wikipedia-org-4107	126	7	-	-	HYPH
en-wikipedia-org-4107	126	8	related	relate	VBN
en-wikipedia-org-4107	126	9	plasticity	plasticity	NN
en-wikipedia-org-4107	126	10	Form	form	NN
en-wikipedia-org-4107	126	11	of	of	IN
en-wikipedia-org-4107	126	12	neuroplasticity	neuroplasticity	NN
en-wikipedia-org-4107	126	13	or	or	CC
en-wikipedia-org-4107	126	14	behavioral	behavioral	JJ
en-wikipedia-org-4107	126	15	plasticity	plasticity	NN
en-wikipedia-org-4107	126	16	Type	type	NN
en-wikipedia-org-4107	126	17	of	of	IN
en-wikipedia-org-4107	126	18	reinforcer	reinforcer	NN
en-wikipedia-org-4107	126	19	Sources	source	NNS
en-wikipedia-org-4107	126	20	Opiates	opiate	VBZ
en-wikipedia-org-4107	126	21	Psychostimulants	Psychostimulants	NNP
en-wikipedia-org-4107	126	22	High	high	JJ
en-wikipedia-org-4107	126	23	fat	fat	NN
en-wikipedia-org-4107	126	24	or	or	CC
en-wikipedia-org-4107	126	25	sugar	sugar	NN
en-wikipedia-org-4107	126	26	food	food	NN
en-wikipedia-org-4107	126	27	Sexual	sexual	JJ
en-wikipedia-org-4107	126	28	intercourse	intercourse	VB
en-wikipedia-org-4107	126	29	Physical	physical	JJ
en-wikipedia-org-4107	126	30	exercise	exercise	NN
en-wikipedia-org-4107	126	31	(	(	-LRB-
en-wikipedia-org-4107	126	32	aerobic	aerobic	JJ
en-wikipedia-org-4107	126	33	)	)	-RRB-
en-wikipedia-org-4107	126	34	Environmental	environmental	JJ
en-wikipedia-org-4107	126	35	enrichment	enrichment	NN
en-wikipedia-org-4107	126	36	ΔFosB	ΔFosB	VBZ
en-wikipedia-org-4107	126	37	expression	expression	NN
en-wikipedia-org-4107	126	38	in	in	IN
en-wikipedia-org-4107	126	39	nucleus	nucleus	NN
en-wikipedia-org-4107	126	40	accumbens	accumben	VBZ
en-wikipedia-org-4107	126	41	D1-type	D1-type	NNP
en-wikipedia-org-4107	126	42	MSNs	msn	NNS
en-wikipedia-org-4107	126	43	↑	↑	VBP
en-wikipedia-org-4107	126	44	↑	↑	NN
en-wikipedia-org-4107	126	45	↑	↑	NNP
en-wikipedia-org-4107	126	46	↑	↑	NNP
en-wikipedia-org-4107	126	47	↑	↑	NNP
en-wikipedia-org-4107	126	48	↑	↑	NNP
en-wikipedia-org-4107	126	49	[	[	-LRB-
en-wikipedia-org-4107	126	50	110	110	CD
en-wikipedia-org-4107	126	51	]	]	-RRB-
en-wikipedia-org-4107	126	52	Behavioral	behavioral	JJ
en-wikipedia-org-4107	126	53	plasticity	plasticity	NN
en-wikipedia-org-4107	126	54	Escalation	escalation	NN
en-wikipedia-org-4107	126	55	of	of	IN
en-wikipedia-org-4107	126	56	intake	intake	NN
en-wikipedia-org-4107	126	57	Yes	yes	UH
en-wikipedia-org-4107	126	58	Yes	yes	UH
en-wikipedia-org-4107	126	59	Yes	yes	UH
en-wikipedia-org-4107	126	60	[	[	-LRB-
en-wikipedia-org-4107	126	61	110	110	CD
en-wikipedia-org-4107	126	62	]	]	-RRB-
en-wikipedia-org-4107	126	63	Psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	126	64	cross	cross	JJ
en-wikipedia-org-4107	126	65	-	-	NN
en-wikipedia-org-4107	126	66	sensitization	sensitization	JJ
en-wikipedia-org-4107	126	67	Yes	yes	UH
en-wikipedia-org-4107	126	68	Not	not	RB
en-wikipedia-org-4107	126	69	applicable	applicable	JJ
en-wikipedia-org-4107	126	70	Yes	yes	UH
en-wikipedia-org-4107	126	71	Yes	yes	UH
en-wikipedia-org-4107	126	72	Attenuated	Attenuated	NNP
en-wikipedia-org-4107	126	73	Attenuated	Attenuated	NNP
en-wikipedia-org-4107	126	74	[	[	-LRB-
en-wikipedia-org-4107	126	75	110	110	CD
en-wikipedia-org-4107	126	76	]	]	-RRB-
en-wikipedia-org-4107	126	77	Psychostimulant	Psychostimulant	NNP
en-wikipedia-org-4107	126	78	self	self	NN
en-wikipedia-org-4107	126	79	-	-	HYPH
en-wikipedia-org-4107	126	80	administration	administration	NN
en-wikipedia-org-4107	126	81	↑	↑	NN
en-wikipedia-org-4107	126	82	↑	↑	NN
en-wikipedia-org-4107	126	83	↓	↓	NNP
en-wikipedia-org-4107	126	84	↓	↓	NNP
en-wikipedia-org-4107	126	85	↓	↓	NNP
en-wikipedia-org-4107	126	86	[	[	-LRB-
en-wikipedia-org-4107	126	87	110	110	CD
en-wikipedia-org-4107	126	88	]	]	-RRB-
en-wikipedia-org-4107	126	89	Psychostimulant	psychostimulant	NN
en-wikipedia-org-4107	126	90	conditioned	condition	VBN
en-wikipedia-org-4107	126	91	place	place	NN
en-wikipedia-org-4107	126	92	preference	preference	NN
en-wikipedia-org-4107	126	93	↑	↑	NN
en-wikipedia-org-4107	126	94	↑	↑	NN
en-wikipedia-org-4107	126	95	↓	↓	NNP
en-wikipedia-org-4107	126	96	↑	↑	VBP
en-wikipedia-org-4107	126	97	↓	↓	NNP
en-wikipedia-org-4107	126	98	↑	↑	NN
en-wikipedia-org-4107	126	99	[	[	-LRB-
en-wikipedia-org-4107	126	100	110	110	CD
en-wikipedia-org-4107	126	101	]	]	-RRB-
en-wikipedia-org-4107	126	102	Reinstatement	Reinstatement	NNP
en-wikipedia-org-4107	126	103	of	of	IN
en-wikipedia-org-4107	126	104	drug	drug	NN
en-wikipedia-org-4107	126	105	-	-	HYPH
en-wikipedia-org-4107	126	106	seeking	seek	VBG
en-wikipedia-org-4107	126	107	behavior	behavior	NN
en-wikipedia-org-4107	126	108	↑	↑	NN
en-wikipedia-org-4107	126	109	↑	↑	NN
en-wikipedia-org-4107	126	110	↓	↓	NNP
en-wikipedia-org-4107	126	111	↓	↓	NNP
en-wikipedia-org-4107	126	112	[	[	-LRB-
en-wikipedia-org-4107	126	113	110	110	CD
en-wikipedia-org-4107	126	114	]	]	-RRB-
en-wikipedia-org-4107	126	115	Neurochemical	neurochemical	JJ
en-wikipedia-org-4107	126	116	plasticity	plasticity	NN
en-wikipedia-org-4107	126	117	CREB	CREB	NNP
en-wikipedia-org-4107	126	118	phosphorylation	phosphorylation	NN
en-wikipedia-org-4107	126	119	in	in	IN
en-wikipedia-org-4107	126	120	the	the	DT
en-wikipedia-org-4107	126	121	nucleus	nucleus	NN
en-wikipedia-org-4107	126	122	accumbens	accumben	VBZ
en-wikipedia-org-4107	126	123	↓	↓	NNP
en-wikipedia-org-4107	126	124	↓	↓	NNP
en-wikipedia-org-4107	126	125	↓	↓	NNP
en-wikipedia-org-4107	126	126	↓	↓	NNP
en-wikipedia-org-4107	126	127	↓	↓	NNP
en-wikipedia-org-4107	126	128	[	[	-LRB-
en-wikipedia-org-4107	126	129	110	110	CD
en-wikipedia-org-4107	126	130	]	]	-RRB-
en-wikipedia-org-4107	126	131	Sensitized	sensitized	JJ
en-wikipedia-org-4107	126	132	dopamine	dopamine	NN
en-wikipedia-org-4107	126	133	response	response	NN
en-wikipedia-org-4107	126	134	in	in	IN
en-wikipedia-org-4107	126	135	the	the	DT
en-wikipedia-org-4107	126	136	nucleus	nucleus	NN
en-wikipedia-org-4107	126	137	accumbens	accumben	VBZ
en-wikipedia-org-4107	126	138	No	no	UH
en-wikipedia-org-4107	126	139	Yes	yes	UH
en-wikipedia-org-4107	126	140	No	no	UH
en-wikipedia-org-4107	126	141	Yes	yes	UH
en-wikipedia-org-4107	126	142	[	[	-LRB-
en-wikipedia-org-4107	126	143	110	110	CD
en-wikipedia-org-4107	126	144	]	]	-RRB-
en-wikipedia-org-4107	126	145	Altered	Altered	NNP
en-wikipedia-org-4107	126	146	striatal	striatal	JJ
en-wikipedia-org-4107	126	147	dopamine	dopamine	NN
en-wikipedia-org-4107	126	148	signaling	signaling	NN
en-wikipedia-org-4107	126	149	↓DRD2	↓drd2	RB
en-wikipedia-org-4107	126	150	,	,	,
en-wikipedia-org-4107	126	151	↑DRD3	↑DRD3	NNP
en-wikipedia-org-4107	126	152	↑DRD1	↑DRD1	NNP
en-wikipedia-org-4107	126	153	,	,	,
en-wikipedia-org-4107	126	154	↓DRD2	↓drd2	RB
en-wikipedia-org-4107	126	155	,	,	,
en-wikipedia-org-4107	126	156	↑DRD3	↑DRD3	NNP
en-wikipedia-org-4107	126	157	↑DRD1	↑DRD1	NNP
en-wikipedia-org-4107	126	158	,	,	,
en-wikipedia-org-4107	126	159	↓DRD2	↓drd2	RB
en-wikipedia-org-4107	126	160	,	,	,
en-wikipedia-org-4107	126	161	↑DRD3	↑DRD3	NNP
en-wikipedia-org-4107	126	162	↑DRD2	↑DRD2	VBD
en-wikipedia-org-4107	126	163	↑DRD2	↑drd2	DT
en-wikipedia-org-4107	126	164	[	[	-LRB-
en-wikipedia-org-4107	126	165	110	110	CD
en-wikipedia-org-4107	126	166	]	]	-RRB-
en-wikipedia-org-4107	126	167	Altered	altered	JJ
en-wikipedia-org-4107	126	168	striatal	striatal	JJ
en-wikipedia-org-4107	126	169	opioid	opioid	NN
en-wikipedia-org-4107	126	170	signaling	signal	VBG
en-wikipedia-org-4107	126	171	No	no	DT
en-wikipedia-org-4107	126	172	change	change	NN
en-wikipedia-org-4107	126	173	or	or	CC
en-wikipedia-org-4107	126	174	↑μ	↑μ	NNP
en-wikipedia-org-4107	126	175	-	-	HYPH
en-wikipedia-org-4107	126	176	opioid	opioid	NNP
en-wikipedia-org-4107	126	177	receptors	receptor	NNS
en-wikipedia-org-4107	126	178	↑μ	↑μ	NNP
en-wikipedia-org-4107	126	179	-	-	HYPH
en-wikipedia-org-4107	126	180	opioid	opioid	NN
en-wikipedia-org-4107	126	181	receptors	receptor	NNS
en-wikipedia-org-4107	126	182	↑κ	↑κ	NN
en-wikipedia-org-4107	126	183	-	-	HYPH
en-wikipedia-org-4107	126	184	opioid	opioid	NN
en-wikipedia-org-4107	126	185	receptors	receptor	NNS
en-wikipedia-org-4107	126	186	↑μ	↑μ	NNP
en-wikipedia-org-4107	126	187	-	-	HYPH
en-wikipedia-org-4107	126	188	opioid	opioid	NNP
en-wikipedia-org-4107	126	189	receptors	receptor	NNS
en-wikipedia-org-4107	126	190	↑μ	↑μ	NNP
en-wikipedia-org-4107	126	191	-	-	HYPH
en-wikipedia-org-4107	126	192	opioid	opioid	NNP
en-wikipedia-org-4107	126	193	receptors	receptor	NNS
en-wikipedia-org-4107	126	194	No	no	DT
en-wikipedia-org-4107	126	195	change	change	VBP
en-wikipedia-org-4107	126	196	No	no	DT
en-wikipedia-org-4107	126	197	change	change	NN
en-wikipedia-org-4107	126	198	[	[	-LRB-
en-wikipedia-org-4107	126	199	110	110	CD
en-wikipedia-org-4107	126	200	]	]	-RRB-
en-wikipedia-org-4107	126	201	Changes	change	NNS
en-wikipedia-org-4107	126	202	in	in	IN
en-wikipedia-org-4107	126	203	striatal	striatal	JJ
en-wikipedia-org-4107	126	204	opioid	opioid	NN
en-wikipedia-org-4107	126	205	peptides	peptide	NNS
en-wikipedia-org-4107	126	206	↑dynorphin	↑dynorphin	.
en-wikipedia-org-4107	126	207	No	no	DT
en-wikipedia-org-4107	126	208	change	change	NN
en-wikipedia-org-4107	126	209	:	:	:
en-wikipedia-org-4107	126	210	enkephalin	enkephalin	NNP
en-wikipedia-org-4107	126	211	↑dynorphin	↑dynorphin	.
en-wikipedia-org-4107	126	212	↓enkephalin	↓enkephalin	NNP
en-wikipedia-org-4107	126	213	↑dynorphin	↑dynorphin	NNP
en-wikipedia-org-4107	126	214	↑dynorphin	↑dynorphin	NNP
en-wikipedia-org-4107	126	215	[	[	-LRB-
en-wikipedia-org-4107	126	216	110	110	CD
en-wikipedia-org-4107	126	217	]	]	-RRB-
en-wikipedia-org-4107	126	218	Mesocorticolimbic	mesocorticolimbic	JJ
en-wikipedia-org-4107	126	219	synaptic	synaptic	JJ
en-wikipedia-org-4107	126	220	plasticity	plasticity	NN
en-wikipedia-org-4107	126	221	Number	number	NN
en-wikipedia-org-4107	126	222	of	of	IN
en-wikipedia-org-4107	126	223	dendrites	dendrite	NNS
en-wikipedia-org-4107	126	224	in	in	IN
en-wikipedia-org-4107	126	225	the	the	DT
en-wikipedia-org-4107	126	226	nucleus	nucleus	NN
en-wikipedia-org-4107	126	227	accumbens	accumben	VBZ
en-wikipedia-org-4107	126	228	↓	↓	NNP
en-wikipedia-org-4107	126	229	↑	↑	NN
en-wikipedia-org-4107	126	230	↑	↑	NN
en-wikipedia-org-4107	126	231	[	[	-LRB-
en-wikipedia-org-4107	126	232	110	110	CD
en-wikipedia-org-4107	126	233	]	]	-RRB-
en-wikipedia-org-4107	126	234	Dendritic	dendritic	JJ
en-wikipedia-org-4107	126	235	spine	spine	NN
en-wikipedia-org-4107	126	236	density	density	NN
en-wikipedia-org-4107	126	237	in	in	IN
en-wikipedia-org-4107	126	238	the	the	DT
en-wikipedia-org-4107	126	239	nucleus	nucleus	NN
en-wikipedia-org-4107	126	240	accumbens	accumben	VBZ
en-wikipedia-org-4107	126	241	↓	↓	NNP
en-wikipedia-org-4107	126	242	↑	↑	NN
en-wikipedia-org-4107	126	243	↑	↑	NN
en-wikipedia-org-4107	126	244	[	[	-LRB-
en-wikipedia-org-4107	126	245	110	110	CD
en-wikipedia-org-4107	126	246	]	]	-RRB-
en-wikipedia-org-4107	126	247	Dependence	dependence	NN
en-wikipedia-org-4107	126	248	and	and	CC
en-wikipedia-org-4107	126	249	withdrawal	withdrawal	NN
en-wikipedia-org-4107	126	250	Drug	Drug	NNP
en-wikipedia-org-4107	126	251	tolerance	tolerance	NN
en-wikipedia-org-4107	126	252	develops	develop	VBZ
en-wikipedia-org-4107	126	253	rapidly	rapidly	RB
en-wikipedia-org-4107	126	254	in	in	IN
en-wikipedia-org-4107	126	255	amphetamine	amphetamine	NN
en-wikipedia-org-4107	126	256	abuse	abuse	NN
en-wikipedia-org-4107	126	257	(	(	-LRB-
en-wikipedia-org-4107	126	258	i.e.	i.e.	FW
en-wikipedia-org-4107	126	259	,	,	,
en-wikipedia-org-4107	126	260	recreational	recreational	JJ
en-wikipedia-org-4107	126	261	amphetamine	amphetamine	NN
en-wikipedia-org-4107	126	262	use	use	NN
en-wikipedia-org-4107	126	263	)	)	-RRB-
en-wikipedia-org-4107	126	264	,	,	,
en-wikipedia-org-4107	126	265	so	so	IN
en-wikipedia-org-4107	126	266	periods	period	NNS
en-wikipedia-org-4107	126	267	of	of	IN
en-wikipedia-org-4107	126	268	extended	extended	JJ
en-wikipedia-org-4107	126	269	abuse	abuse	NN
en-wikipedia-org-4107	126	270	require	require	VBP
en-wikipedia-org-4107	126	271	increasingly	increasingly	RB
en-wikipedia-org-4107	126	272	larger	large	JJR
en-wikipedia-org-4107	126	273	doses	dose	NNS
en-wikipedia-org-4107	126	274	of	of	IN
en-wikipedia-org-4107	126	275	the	the	DT
en-wikipedia-org-4107	126	276	drug	drug	NN
en-wikipedia-org-4107	126	277	in	in	IN
en-wikipedia-org-4107	126	278	order	order	NN
en-wikipedia-org-4107	126	279	to	to	TO
en-wikipedia-org-4107	126	280	achieve	achieve	VB
en-wikipedia-org-4107	126	281	the	the	DT
en-wikipedia-org-4107	126	282	same	same	JJ
en-wikipedia-org-4107	126	283	effect	effect	NN
en-wikipedia-org-4107	126	284	.	.	.
en-wikipedia-org-4107	127	1	[	[	-LRB-
en-wikipedia-org-4107	127	2	133][134	133][134	LS
en-wikipedia-org-4107	127	3	]	]	-RRB-
en-wikipedia-org-4107	127	4	According	accord	VBG
en-wikipedia-org-4107	127	5	to	to	IN
en-wikipedia-org-4107	127	6	a	a	DT
en-wikipedia-org-4107	127	7	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	127	8	review	review	NN
en-wikipedia-org-4107	127	9	on	on	IN
en-wikipedia-org-4107	127	10	withdrawal	withdrawal	NN
en-wikipedia-org-4107	127	11	in	in	IN
en-wikipedia-org-4107	127	12	individuals	individual	NNS
en-wikipedia-org-4107	127	13	who	who	WP
en-wikipedia-org-4107	127	14	compulsively	compulsively	RB
en-wikipedia-org-4107	127	15	use	use	VBP
en-wikipedia-org-4107	127	16	amphetamine	amphetamine	NN
en-wikipedia-org-4107	127	17	and	and	CC
en-wikipedia-org-4107	127	18	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	127	19	,	,	,
en-wikipedia-org-4107	127	20	"	"	''
en-wikipedia-org-4107	127	21	when	when	WRB
en-wikipedia-org-4107	127	22	chronic	chronic	JJ
en-wikipedia-org-4107	127	23	heavy	heavy	JJ
en-wikipedia-org-4107	127	24	users	user	NNS
en-wikipedia-org-4107	127	25	abruptly	abruptly	RB
en-wikipedia-org-4107	127	26	discontinue	discontinue	VBP
en-wikipedia-org-4107	127	27	amphetamine	amphetamine	NN
en-wikipedia-org-4107	127	28	use	use	NN
en-wikipedia-org-4107	127	29	,	,	,
en-wikipedia-org-4107	127	30	many	many	JJ
en-wikipedia-org-4107	127	31	report	report	VBP
en-wikipedia-org-4107	127	32	a	a	DT
en-wikipedia-org-4107	127	33	time	time	NN
en-wikipedia-org-4107	127	34	-	-	HYPH
en-wikipedia-org-4107	127	35	limited	limit	VBN
en-wikipedia-org-4107	127	36	withdrawal	withdrawal	NN
en-wikipedia-org-4107	127	37	syndrome	syndrome	NN
en-wikipedia-org-4107	127	38	that	that	WDT
en-wikipedia-org-4107	127	39	occurs	occur	VBZ
en-wikipedia-org-4107	127	40	within	within	IN
en-wikipedia-org-4107	127	41	24	24	CD
en-wikipedia-org-4107	127	42	 	  	_SP
en-wikipedia-org-4107	127	43	hours	hour	NNS
en-wikipedia-org-4107	127	44	of	of	IN
en-wikipedia-org-4107	127	45	their	-PRON-	PRP$
en-wikipedia-org-4107	127	46	last	last	JJ
en-wikipedia-org-4107	127	47	dose	dose	NN
en-wikipedia-org-4107	127	48	.	.	.
en-wikipedia-org-4107	128	1	"	"	``
en-wikipedia-org-4107	128	2	[	[	-LRB-
en-wikipedia-org-4107	128	3	135	135	CD
en-wikipedia-org-4107	128	4	]	]	-RRB-
en-wikipedia-org-4107	128	5	This	this	DT
en-wikipedia-org-4107	128	6	review	review	NN
en-wikipedia-org-4107	128	7	noted	note	VBD
en-wikipedia-org-4107	128	8	that	that	IN
en-wikipedia-org-4107	128	9	withdrawal	withdrawal	NN
en-wikipedia-org-4107	128	10	symptoms	symptom	NNS
en-wikipedia-org-4107	128	11	in	in	IN
en-wikipedia-org-4107	128	12	chronic	chronic	JJ
en-wikipedia-org-4107	128	13	,	,	,
en-wikipedia-org-4107	128	14	high	high	JJ
en-wikipedia-org-4107	128	15	-	-	HYPH
en-wikipedia-org-4107	128	16	dose	dose	JJ
en-wikipedia-org-4107	128	17	users	user	NNS
en-wikipedia-org-4107	128	18	are	be	VBP
en-wikipedia-org-4107	128	19	frequent	frequent	JJ
en-wikipedia-org-4107	128	20	,	,	,
en-wikipedia-org-4107	128	21	occurring	occur	VBG
en-wikipedia-org-4107	128	22	in	in	IN
en-wikipedia-org-4107	128	23	roughly	roughly	RB
en-wikipedia-org-4107	128	24	88	88	CD
en-wikipedia-org-4107	128	25	%	%	NN
en-wikipedia-org-4107	128	26	of	of	IN
en-wikipedia-org-4107	128	27	cases	case	NNS
en-wikipedia-org-4107	128	28	,	,	,
en-wikipedia-org-4107	128	29	and	and	CC
en-wikipedia-org-4107	128	30	persist	persist	VB
en-wikipedia-org-4107	128	31	for	for	IN
en-wikipedia-org-4107	128	32	3–4	3–4	CD
en-wikipedia-org-4107	128	33	 	  	_SP
en-wikipedia-org-4107	128	34	weeks	week	NNS
en-wikipedia-org-4107	128	35	with	with	IN
en-wikipedia-org-4107	128	36	a	a	DT
en-wikipedia-org-4107	128	37	marked	marked	JJ
en-wikipedia-org-4107	128	38	"	"	``
en-wikipedia-org-4107	128	39	crash	crash	NN
en-wikipedia-org-4107	128	40	"	"	''
en-wikipedia-org-4107	128	41	phase	phase	NN
en-wikipedia-org-4107	128	42	occurring	occur	VBG
en-wikipedia-org-4107	128	43	during	during	IN
en-wikipedia-org-4107	128	44	the	the	DT
en-wikipedia-org-4107	128	45	first	first	JJ
en-wikipedia-org-4107	128	46	week	week	NN
en-wikipedia-org-4107	128	47	.	.	.
en-wikipedia-org-4107	129	1	[	[	-LRB-
en-wikipedia-org-4107	129	2	135	135	CD
en-wikipedia-org-4107	129	3	]	]	-RRB-
en-wikipedia-org-4107	129	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	129	5	withdrawal	withdrawal	NN
en-wikipedia-org-4107	129	6	symptoms	symptom	NNS
en-wikipedia-org-4107	129	7	can	can	MD
en-wikipedia-org-4107	129	8	include	include	VB
en-wikipedia-org-4107	129	9	anxiety	anxiety	NN
en-wikipedia-org-4107	129	10	,	,	,
en-wikipedia-org-4107	129	11	drug	drug	NN
en-wikipedia-org-4107	129	12	craving	craving	NN
en-wikipedia-org-4107	129	13	,	,	,
en-wikipedia-org-4107	129	14	depressed	depressed	JJ
en-wikipedia-org-4107	129	15	mood	mood	NN
en-wikipedia-org-4107	129	16	,	,	,
en-wikipedia-org-4107	129	17	fatigue	fatigue	NN
en-wikipedia-org-4107	129	18	,	,	,
en-wikipedia-org-4107	129	19	increased	increase	VBN
en-wikipedia-org-4107	129	20	appetite	appetite	NN
en-wikipedia-org-4107	129	21	,	,	,
en-wikipedia-org-4107	129	22	increased	increase	VBN
en-wikipedia-org-4107	129	23	movement	movement	NN
en-wikipedia-org-4107	129	24	or	or	CC
en-wikipedia-org-4107	129	25	decreased	decrease	VBN
en-wikipedia-org-4107	129	26	movement	movement	NN
en-wikipedia-org-4107	129	27	,	,	,
en-wikipedia-org-4107	129	28	lack	lack	NN
en-wikipedia-org-4107	129	29	of	of	IN
en-wikipedia-org-4107	129	30	motivation	motivation	NN
en-wikipedia-org-4107	129	31	,	,	,
en-wikipedia-org-4107	129	32	sleeplessness	sleeplessness	NN
en-wikipedia-org-4107	129	33	or	or	CC
en-wikipedia-org-4107	129	34	sleepiness	sleepiness	NN
en-wikipedia-org-4107	129	35	,	,	,
en-wikipedia-org-4107	129	36	and	and	CC
en-wikipedia-org-4107	129	37	lucid	lucid	JJ
en-wikipedia-org-4107	129	38	dreams	dream	NNS
en-wikipedia-org-4107	129	39	.	.	.
en-wikipedia-org-4107	130	1	[	[	-LRB-
en-wikipedia-org-4107	130	2	135	135	CD
en-wikipedia-org-4107	130	3	]	]	-RRB-
en-wikipedia-org-4107	130	4	The	the	DT
en-wikipedia-org-4107	130	5	review	review	NN
en-wikipedia-org-4107	130	6	indicated	indicate	VBD
en-wikipedia-org-4107	130	7	that	that	IN
en-wikipedia-org-4107	130	8	the	the	DT
en-wikipedia-org-4107	130	9	severity	severity	NN
en-wikipedia-org-4107	130	10	of	of	IN
en-wikipedia-org-4107	130	11	withdrawal	withdrawal	NN
en-wikipedia-org-4107	130	12	symptoms	symptom	NNS
en-wikipedia-org-4107	130	13	is	be	VBZ
en-wikipedia-org-4107	130	14	positively	positively	RB
en-wikipedia-org-4107	130	15	correlated	correlate	VBN
en-wikipedia-org-4107	130	16	with	with	IN
en-wikipedia-org-4107	130	17	the	the	DT
en-wikipedia-org-4107	130	18	age	age	NN
en-wikipedia-org-4107	130	19	of	of	IN
en-wikipedia-org-4107	130	20	the	the	DT
en-wikipedia-org-4107	130	21	individual	individual	NN
en-wikipedia-org-4107	130	22	and	and	CC
en-wikipedia-org-4107	130	23	the	the	DT
en-wikipedia-org-4107	130	24	extent	extent	NN
en-wikipedia-org-4107	130	25	of	of	IN
en-wikipedia-org-4107	130	26	their	-PRON-	PRP$
en-wikipedia-org-4107	130	27	dependence	dependence	NN
en-wikipedia-org-4107	130	28	.	.	.
en-wikipedia-org-4107	131	1	[	[	-LRB-
en-wikipedia-org-4107	131	2	135	135	CD
en-wikipedia-org-4107	131	3	]	]	-RRB-
en-wikipedia-org-4107	131	4	Mild	mild	JJ
en-wikipedia-org-4107	131	5	withdrawal	withdrawal	NN
en-wikipedia-org-4107	131	6	symptoms	symptom	NNS
en-wikipedia-org-4107	131	7	from	from	IN
en-wikipedia-org-4107	131	8	the	the	DT
en-wikipedia-org-4107	131	9	discontinuation	discontinuation	NN
en-wikipedia-org-4107	131	10	of	of	IN
en-wikipedia-org-4107	131	11	amphetamine	amphetamine	NN
en-wikipedia-org-4107	131	12	treatment	treatment	NN
en-wikipedia-org-4107	131	13	at	at	IN
en-wikipedia-org-4107	131	14	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	131	15	doses	dose	NNS
en-wikipedia-org-4107	131	16	can	can	MD
en-wikipedia-org-4107	131	17	be	be	VB
en-wikipedia-org-4107	131	18	avoided	avoid	VBN
en-wikipedia-org-4107	131	19	by	by	IN
en-wikipedia-org-4107	131	20	tapering	taper	VBG
en-wikipedia-org-4107	131	21	the	the	DT
en-wikipedia-org-4107	131	22	dose	dose	NN
en-wikipedia-org-4107	131	23	.	.	.
en-wikipedia-org-4107	132	1	[	[	-LRB-
en-wikipedia-org-4107	132	2	2	2	LS
en-wikipedia-org-4107	132	3	]	]	-RRB-
en-wikipedia-org-4107	132	4	Overdose	overdose	VB
en-wikipedia-org-4107	132	5	An	an	DT
en-wikipedia-org-4107	132	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	132	7	overdose	overdose	WDT
en-wikipedia-org-4107	132	8	can	can	MD
en-wikipedia-org-4107	132	9	lead	lead	VB
en-wikipedia-org-4107	132	10	to	to	IN
en-wikipedia-org-4107	132	11	many	many	JJ
en-wikipedia-org-4107	132	12	different	different	JJ
en-wikipedia-org-4107	132	13	symptoms	symptom	NNS
en-wikipedia-org-4107	132	14	,	,	,
en-wikipedia-org-4107	132	15	but	but	CC
en-wikipedia-org-4107	132	16	is	be	VBZ
en-wikipedia-org-4107	132	17	rarely	rarely	RB
en-wikipedia-org-4107	132	18	fatal	fatal	JJ
en-wikipedia-org-4107	132	19	with	with	IN
en-wikipedia-org-4107	132	20	appropriate	appropriate	JJ
en-wikipedia-org-4107	132	21	care	care	NN
en-wikipedia-org-4107	132	22	.	.	.
en-wikipedia-org-4107	133	1	[	[	-LRB-
en-wikipedia-org-4107	133	2	2][84][136	2][84][136	LS
en-wikipedia-org-4107	133	3	]	]	-RRB-
en-wikipedia-org-4107	133	4	The	the	DT
en-wikipedia-org-4107	133	5	severity	severity	NN
en-wikipedia-org-4107	133	6	of	of	IN
en-wikipedia-org-4107	133	7	overdose	overdose	NN
en-wikipedia-org-4107	133	8	symptoms	symptom	NNS
en-wikipedia-org-4107	133	9	increases	increase	NNS
en-wikipedia-org-4107	133	10	with	with	IN
en-wikipedia-org-4107	133	11	dosage	dosage	NN
en-wikipedia-org-4107	133	12	and	and	CC
en-wikipedia-org-4107	133	13	decreases	decrease	VBZ
en-wikipedia-org-4107	133	14	with	with	IN
en-wikipedia-org-4107	133	15	drug	drug	NN
en-wikipedia-org-4107	133	16	tolerance	tolerance	NN
en-wikipedia-org-4107	133	17	to	to	TO
en-wikipedia-org-4107	133	18	amphetamine	amphetamine	VB
en-wikipedia-org-4107	133	19	.	.	.
en-wikipedia-org-4107	134	1	[	[	-LRB-
en-wikipedia-org-4107	134	2	39][84	39][84	LS
en-wikipedia-org-4107	134	3	]	]	-RRB-
en-wikipedia-org-4107	134	4	Tolerant	tolerant	JJ
en-wikipedia-org-4107	134	5	individuals	individual	NNS
en-wikipedia-org-4107	134	6	have	have	VBP
en-wikipedia-org-4107	134	7	been	be	VBN
en-wikipedia-org-4107	134	8	known	know	VBN
en-wikipedia-org-4107	134	9	to	to	TO
en-wikipedia-org-4107	134	10	take	take	VB
en-wikipedia-org-4107	134	11	as	as	RB
en-wikipedia-org-4107	134	12	much	much	JJ
en-wikipedia-org-4107	134	13	as	as	IN
en-wikipedia-org-4107	134	14	5	5	CD
en-wikipedia-org-4107	134	15	 	  	_SP
en-wikipedia-org-4107	134	16	grams	gram	NNS
en-wikipedia-org-4107	134	17	of	of	IN
en-wikipedia-org-4107	134	18	amphetamine	amphetamine	NN
en-wikipedia-org-4107	134	19	in	in	IN
en-wikipedia-org-4107	134	20	a	a	DT
en-wikipedia-org-4107	134	21	day	day	NN
en-wikipedia-org-4107	134	22	,	,	,
en-wikipedia-org-4107	134	23	which	which	WDT
en-wikipedia-org-4107	134	24	is	be	VBZ
en-wikipedia-org-4107	134	25	roughly	roughly	RB
en-wikipedia-org-4107	134	26	100	100	CD
en-wikipedia-org-4107	134	27	 	  	_SP
en-wikipedia-org-4107	134	28	times	time	NNS
en-wikipedia-org-4107	134	29	the	the	DT
en-wikipedia-org-4107	134	30	maximum	maximum	JJ
en-wikipedia-org-4107	134	31	daily	daily	JJ
en-wikipedia-org-4107	134	32	therapeutic	therapeutic	NN
en-wikipedia-org-4107	134	33	dose	dose	NN
en-wikipedia-org-4107	134	34	.	.	.
en-wikipedia-org-4107	135	1	[	[	-LRB-
en-wikipedia-org-4107	135	2	84	84	CD
en-wikipedia-org-4107	135	3	]	]	-RRB-
en-wikipedia-org-4107	135	4	Symptoms	symptom	NNS
en-wikipedia-org-4107	135	5	of	of	IN
en-wikipedia-org-4107	135	6	a	a	DT
en-wikipedia-org-4107	135	7	moderate	moderate	JJ
en-wikipedia-org-4107	135	8	and	and	CC
en-wikipedia-org-4107	135	9	extremely	extremely	RB
en-wikipedia-org-4107	135	10	large	large	JJ
en-wikipedia-org-4107	135	11	overdose	overdose	NNS
en-wikipedia-org-4107	135	12	are	be	VBP
en-wikipedia-org-4107	135	13	listed	list	VBN
en-wikipedia-org-4107	135	14	below	below	RB
en-wikipedia-org-4107	135	15	;	;	:
en-wikipedia-org-4107	135	16	fatal	fatal	JJ
en-wikipedia-org-4107	135	17	amphetamine	amphetamine	NN
en-wikipedia-org-4107	135	18	poisoning	poisoning	NN
en-wikipedia-org-4107	135	19	usually	usually	RB
en-wikipedia-org-4107	135	20	also	also	RB
en-wikipedia-org-4107	135	21	involves	involve	VBZ
en-wikipedia-org-4107	135	22	convulsions	convulsion	NNS
en-wikipedia-org-4107	135	23	and	and	CC
en-wikipedia-org-4107	135	24	coma	coma	NN
en-wikipedia-org-4107	135	25	.	.	.
en-wikipedia-org-4107	136	1	[	[	-LRB-
en-wikipedia-org-4107	136	2	28][39	28][39	LS
en-wikipedia-org-4107	136	3	]	]	-RRB-
en-wikipedia-org-4107	136	4	In	in	IN
en-wikipedia-org-4107	136	5	2013	2013	CD
en-wikipedia-org-4107	136	6	,	,	,
en-wikipedia-org-4107	136	7	overdose	overdose	VB
en-wikipedia-org-4107	136	8	on	on	IN
en-wikipedia-org-4107	136	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	136	10	,	,	,
en-wikipedia-org-4107	136	11	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	136	12	,	,	,
en-wikipedia-org-4107	136	13	and	and	CC
en-wikipedia-org-4107	136	14	other	other	JJ
en-wikipedia-org-4107	136	15	compounds	compound	NNS
en-wikipedia-org-4107	136	16	implicated	implicate	VBN
en-wikipedia-org-4107	136	17	in	in	IN
en-wikipedia-org-4107	136	18	an	an	DT
en-wikipedia-org-4107	136	19	"	"	``
en-wikipedia-org-4107	136	20	amphetamine	amphetamine	NN
en-wikipedia-org-4107	136	21	use	use	NN
en-wikipedia-org-4107	136	22	disorder	disorder	NN
en-wikipedia-org-4107	136	23	"	"	''
en-wikipedia-org-4107	136	24	resulted	result	VBD
en-wikipedia-org-4107	136	25	in	in	IN
en-wikipedia-org-4107	136	26	an	an	DT
en-wikipedia-org-4107	136	27	estimated	estimated	JJ
en-wikipedia-org-4107	136	28	3,788	3,788	CD
en-wikipedia-org-4107	136	29	 	  	_SP
en-wikipedia-org-4107	136	30	deaths	death	NNS
en-wikipedia-org-4107	136	31	worldwide	worldwide	RB
en-wikipedia-org-4107	136	32	(	(	-LRB-
en-wikipedia-org-4107	136	33	3,425–4,145	3,425–4,145	CD
en-wikipedia-org-4107	136	34	 	  	_SP
en-wikipedia-org-4107	136	35	deaths	death	NNS
en-wikipedia-org-4107	136	36	,	,	,
en-wikipedia-org-4107	136	37	95	95	CD
en-wikipedia-org-4107	136	38	%	%	NN
en-wikipedia-org-4107	136	39	 	  	_SP
en-wikipedia-org-4107	136	40	confidence	confidence	NN
en-wikipedia-org-4107	136	41	)	)	-RRB-
en-wikipedia-org-4107	136	42	.	.	.
en-wikipedia-org-4107	137	1	[	[	-LRB-
en-wikipedia-org-4107	137	2	note	note	NN
en-wikipedia-org-4107	137	3	15][137	15][137	NNS
en-wikipedia-org-4107	137	4	]	]	-RRB-
en-wikipedia-org-4107	137	5	Overdose	overdose	NN
en-wikipedia-org-4107	137	6	symptoms	symptom	NNS
en-wikipedia-org-4107	137	7	by	by	IN
en-wikipedia-org-4107	137	8	system	system	NN
en-wikipedia-org-4107	137	9	System	System	NNP
en-wikipedia-org-4107	137	10	Minor	Minor	NNP
en-wikipedia-org-4107	137	11	or	or	CC
en-wikipedia-org-4107	137	12	moderate	moderate	JJ
en-wikipedia-org-4107	137	13	overdose[28][39][84	overdose[28][39][84	NNS
en-wikipedia-org-4107	137	14	]	]	-RRB-
en-wikipedia-org-4107	137	15	Severe	Severe	NNP
en-wikipedia-org-4107	137	16	overdose[sources	overdose[sources	CD
en-wikipedia-org-4107	137	17	12	12	CD
en-wikipedia-org-4107	137	18	]	]	-RRB-
en-wikipedia-org-4107	137	19	Cardiovascular	Cardiovascular	NNP
en-wikipedia-org-4107	137	20	Abnormal	Abnormal	NNP
en-wikipedia-org-4107	137	21	heartbeat	heartbeat	NN
en-wikipedia-org-4107	137	22	High	high	JJ
en-wikipedia-org-4107	137	23	or	or	CC
en-wikipedia-org-4107	137	24	low	low	JJ
en-wikipedia-org-4107	137	25	blood	blood	NN
en-wikipedia-org-4107	137	26	pressure	pressure	NN
en-wikipedia-org-4107	137	27	Cardiogenic	cardiogenic	JJ
en-wikipedia-org-4107	137	28	shock	shock	NN
en-wikipedia-org-4107	137	29	(	(	-LRB-
en-wikipedia-org-4107	137	30	heart	heart	NN
en-wikipedia-org-4107	137	31	not	not	RB
en-wikipedia-org-4107	137	32	pumping	pump	VBG
en-wikipedia-org-4107	137	33	enough	enough	JJ
en-wikipedia-org-4107	137	34	blood	blood	NN
en-wikipedia-org-4107	137	35	)	)	-RRB-
en-wikipedia-org-4107	137	36	Cerebral	cerebral	JJ
en-wikipedia-org-4107	137	37	hemorrhage	hemorrhage	NN
en-wikipedia-org-4107	137	38	(	(	-LRB-
en-wikipedia-org-4107	137	39	bleeding	bleed	VBG
en-wikipedia-org-4107	137	40	in	in	IN
en-wikipedia-org-4107	137	41	the	the	DT
en-wikipedia-org-4107	137	42	brain	brain	NN
en-wikipedia-org-4107	137	43	)	)	-RRB-
en-wikipedia-org-4107	137	44	Circulatory	circulatory	JJ
en-wikipedia-org-4107	137	45	collapse	collapse	NN
en-wikipedia-org-4107	137	46	(	(	-LRB-
en-wikipedia-org-4107	137	47	partial	partial	JJ
en-wikipedia-org-4107	137	48	or	or	CC
en-wikipedia-org-4107	137	49	complete	complete	JJ
en-wikipedia-org-4107	137	50	failure	failure	NN
en-wikipedia-org-4107	137	51	of	of	IN
en-wikipedia-org-4107	137	52	the	the	DT
en-wikipedia-org-4107	137	53	circulatory	circulatory	JJ
en-wikipedia-org-4107	137	54	system	system	NN
en-wikipedia-org-4107	137	55	)	)	-RRB-
en-wikipedia-org-4107	137	56	Central	central	JJ
en-wikipedia-org-4107	137	57	nervous	nervous	JJ
en-wikipedia-org-4107	137	58	system	system	NN
en-wikipedia-org-4107	137	59	Confusion	Confusion	NNP
en-wikipedia-org-4107	137	60	Abnormally	abnormally	RB
en-wikipedia-org-4107	137	61	fast	fast	VBP
en-wikipedia-org-4107	137	62	reflexes	reflexe	VBZ
en-wikipedia-org-4107	137	63	Severe	severe	JJ
en-wikipedia-org-4107	137	64	agitation	agitation	NN
en-wikipedia-org-4107	137	65	Tremor	Tremor	NNP
en-wikipedia-org-4107	137	66	(	(	-LRB-
en-wikipedia-org-4107	137	67	involuntary	involuntary	JJ
en-wikipedia-org-4107	137	68	muscle	muscle	NN
en-wikipedia-org-4107	137	69	twitching	twitch	VBG
en-wikipedia-org-4107	137	70	)	)	-RRB-
en-wikipedia-org-4107	137	71	Acute	acute	JJ
en-wikipedia-org-4107	137	72	amphetamine	amphetamine	NN
en-wikipedia-org-4107	137	73	psychosis	psychosis	NN
en-wikipedia-org-4107	137	74	(	(	-LRB-
en-wikipedia-org-4107	137	75	e.g.	e.g.	RB
en-wikipedia-org-4107	137	76	,	,	,
en-wikipedia-org-4107	137	77	delusions	delusion	NNS
en-wikipedia-org-4107	137	78	and	and	CC
en-wikipedia-org-4107	137	79	paranoia	paranoia	NN
en-wikipedia-org-4107	137	80	)	)	-RRB-
en-wikipedia-org-4107	137	81	Compulsive	compulsive	JJ
en-wikipedia-org-4107	137	82	and	and	CC
en-wikipedia-org-4107	137	83	repetitive	repetitive	JJ
en-wikipedia-org-4107	137	84	movement	movement	NN
en-wikipedia-org-4107	137	85	Serotonin	Serotonin	NNP
en-wikipedia-org-4107	137	86	syndrome	syndrome	NN
en-wikipedia-org-4107	137	87	(	(	-LRB-
en-wikipedia-org-4107	137	88	excessive	excessive	JJ
en-wikipedia-org-4107	137	89	serotonergic	serotonergic	JJ
en-wikipedia-org-4107	137	90	nerve	nerve	NN
en-wikipedia-org-4107	137	91	activity	activity	NN
en-wikipedia-org-4107	137	92	)	)	-RRB-
en-wikipedia-org-4107	137	93	Sympathomimetic	sympathomimetic	JJ
en-wikipedia-org-4107	137	94	toxidrome	toxidrome	NN
en-wikipedia-org-4107	137	95	(	(	-LRB-
en-wikipedia-org-4107	137	96	excessive	excessive	JJ
en-wikipedia-org-4107	137	97	adrenergic	adrenergic	JJ
en-wikipedia-org-4107	137	98	nerve	nerve	NN
en-wikipedia-org-4107	137	99	activity	activity	NN
en-wikipedia-org-4107	137	100	)	)	-RRB-
en-wikipedia-org-4107	137	101	Musculoskeletal	Musculoskeletal	NNP
en-wikipedia-org-4107	137	102	Muscle	Muscle	NNP
en-wikipedia-org-4107	137	103	pain	pain	NN
en-wikipedia-org-4107	137	104	Rhabdomyolysis	Rhabdomyolysis	NNP
en-wikipedia-org-4107	137	105	(	(	-LRB-
en-wikipedia-org-4107	137	106	rapid	rapid	JJ
en-wikipedia-org-4107	137	107	muscle	muscle	NN
en-wikipedia-org-4107	137	108	breakdown	breakdown	NN
en-wikipedia-org-4107	137	109	)	)	-RRB-
en-wikipedia-org-4107	137	110	Respiratory	Respiratory	NNP
en-wikipedia-org-4107	137	111	Rapid	Rapid	NNP
en-wikipedia-org-4107	137	112	breathing	breathing	NN
en-wikipedia-org-4107	137	113	Pulmonary	pulmonary	JJ
en-wikipedia-org-4107	137	114	edema	edema	NN
en-wikipedia-org-4107	137	115	(	(	-LRB-
en-wikipedia-org-4107	137	116	fluid	fluid	JJ
en-wikipedia-org-4107	137	117	accumulation	accumulation	NN
en-wikipedia-org-4107	137	118	in	in	IN
en-wikipedia-org-4107	137	119	the	the	DT
en-wikipedia-org-4107	137	120	lungs	lung	NNS
en-wikipedia-org-4107	137	121	)	)	-RRB-
en-wikipedia-org-4107	137	122	Pulmonary	pulmonary	JJ
en-wikipedia-org-4107	137	123	hypertension	hypertension	NN
en-wikipedia-org-4107	137	124	(	(	-LRB-
en-wikipedia-org-4107	137	125	high	high	JJ
en-wikipedia-org-4107	137	126	blood	blood	NN
en-wikipedia-org-4107	137	127	pressure	pressure	NN
en-wikipedia-org-4107	137	128	in	in	IN
en-wikipedia-org-4107	137	129	the	the	DT
en-wikipedia-org-4107	137	130	arteries	artery	NNS
en-wikipedia-org-4107	137	131	of	of	IN
en-wikipedia-org-4107	137	132	the	the	DT
en-wikipedia-org-4107	137	133	lung	lung	NN
en-wikipedia-org-4107	137	134	)	)	-RRB-
en-wikipedia-org-4107	137	135	Respiratory	respiratory	JJ
en-wikipedia-org-4107	137	136	alkalosis	alkalosis	NN
en-wikipedia-org-4107	137	137	(	(	-LRB-
en-wikipedia-org-4107	137	138	reduced	reduce	VBN
en-wikipedia-org-4107	137	139	blood	blood	NN
en-wikipedia-org-4107	137	140	CO2	CO2	NNP
en-wikipedia-org-4107	137	141	)	)	-RRB-
en-wikipedia-org-4107	137	142	Urinary	Urinary	NNP
en-wikipedia-org-4107	137	143	Painful	painful	JJ
en-wikipedia-org-4107	137	144	urination	urination	NN
en-wikipedia-org-4107	137	145	Urinary	Urinary	NNP
en-wikipedia-org-4107	137	146	retention	retention	NN
en-wikipedia-org-4107	137	147	(	(	-LRB-
en-wikipedia-org-4107	137	148	inability	inability	NN
en-wikipedia-org-4107	137	149	to	to	TO
en-wikipedia-org-4107	137	150	urinate	urinate	VB
en-wikipedia-org-4107	137	151	)	)	-RRB-
en-wikipedia-org-4107	137	152	No	no	DT
en-wikipedia-org-4107	137	153	urine	urine	NN
en-wikipedia-org-4107	137	154	production	production	NN
en-wikipedia-org-4107	137	155	Kidney	kidney	JJ
en-wikipedia-org-4107	137	156	failure	failure	NN
en-wikipedia-org-4107	137	157	Other	other	JJ
en-wikipedia-org-4107	137	158	Elevated	elevated	JJ
en-wikipedia-org-4107	137	159	body	body	NN
en-wikipedia-org-4107	137	160	temperature	temperature	NN
en-wikipedia-org-4107	137	161	Mydriasis	Mydriasis	NNP
en-wikipedia-org-4107	137	162	(	(	-LRB-
en-wikipedia-org-4107	137	163	dilated	dilate	VBN
en-wikipedia-org-4107	137	164	pupils	pupil	NNS
en-wikipedia-org-4107	137	165	)	)	-RRB-
en-wikipedia-org-4107	137	166	Elevated	elevated	JJ
en-wikipedia-org-4107	137	167	or	or	CC
en-wikipedia-org-4107	137	168	low	low	JJ
en-wikipedia-org-4107	137	169	blood	blood	NN
en-wikipedia-org-4107	137	170	potassium	potassium	NN
en-wikipedia-org-4107	137	171	Hyperpyrexia	Hyperpyrexia	NNP
en-wikipedia-org-4107	137	172	(	(	-LRB-
en-wikipedia-org-4107	137	173	extremely	extremely	RB
en-wikipedia-org-4107	137	174	elevated	elevated	JJ
en-wikipedia-org-4107	137	175	core	core	NN
en-wikipedia-org-4107	137	176	body	body	NN
en-wikipedia-org-4107	137	177	temperature	temperature	NN
en-wikipedia-org-4107	137	178	)	)	-RRB-
en-wikipedia-org-4107	137	179	Metabolic	metabolic	JJ
en-wikipedia-org-4107	137	180	acidosis	acidosis	NN
en-wikipedia-org-4107	137	181	(	(	-LRB-
en-wikipedia-org-4107	137	182	excessively	excessively	RB
en-wikipedia-org-4107	137	183	acidic	acidic	JJ
en-wikipedia-org-4107	137	184	bodily	bodily	RB
en-wikipedia-org-4107	137	185	fluids	fluid	NNS
en-wikipedia-org-4107	137	186	)	)	-RRB-
en-wikipedia-org-4107	137	187	Toxicity	Toxicity	NNP
en-wikipedia-org-4107	137	188	In	in	IN
en-wikipedia-org-4107	137	189	rodents	rodent	NNS
en-wikipedia-org-4107	137	190	and	and	CC
en-wikipedia-org-4107	137	191	primates	primate	NNS
en-wikipedia-org-4107	137	192	,	,	,
en-wikipedia-org-4107	137	193	sufficiently	sufficiently	RB
en-wikipedia-org-4107	137	194	high	high	JJ
en-wikipedia-org-4107	137	195	doses	dose	NNS
en-wikipedia-org-4107	137	196	of	of	IN
en-wikipedia-org-4107	137	197	amphetamine	amphetamine	NN
en-wikipedia-org-4107	137	198	cause	cause	NN
en-wikipedia-org-4107	137	199	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	137	200	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	137	201	,	,	,
en-wikipedia-org-4107	137	202	or	or	CC
en-wikipedia-org-4107	137	203	damage	damage	NN
en-wikipedia-org-4107	137	204	to	to	IN
en-wikipedia-org-4107	137	205	dopamine	dopamine	NN
en-wikipedia-org-4107	137	206	neurons	neuron	NNS
en-wikipedia-org-4107	137	207	,	,	,
en-wikipedia-org-4107	137	208	which	which	WDT
en-wikipedia-org-4107	137	209	is	be	VBZ
en-wikipedia-org-4107	137	210	characterized	characterize	VBN
en-wikipedia-org-4107	137	211	by	by	IN
en-wikipedia-org-4107	137	212	dopamine	dopamine	NN
en-wikipedia-org-4107	137	213	terminal	terminal	NN
en-wikipedia-org-4107	137	214	degeneration	degeneration	NN
en-wikipedia-org-4107	137	215	and	and	CC
en-wikipedia-org-4107	137	216	reduced	reduce	VBN
en-wikipedia-org-4107	137	217	transporter	transporter	NN
en-wikipedia-org-4107	137	218	and	and	CC
en-wikipedia-org-4107	137	219	receptor	receptor	NN
en-wikipedia-org-4107	137	220	function	function	NN
en-wikipedia-org-4107	137	221	.	.	.
en-wikipedia-org-4107	138	1	[	[	-LRB-
en-wikipedia-org-4107	138	2	139][140	139][140	LS
en-wikipedia-org-4107	138	3	]	]	-RRB-
en-wikipedia-org-4107	138	4	There	there	EX
en-wikipedia-org-4107	138	5	is	be	VBZ
en-wikipedia-org-4107	138	6	no	no	DT
en-wikipedia-org-4107	138	7	evidence	evidence	NN
en-wikipedia-org-4107	138	8	that	that	IN
en-wikipedia-org-4107	138	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	138	10	is	be	VBZ
en-wikipedia-org-4107	138	11	directly	directly	RB
en-wikipedia-org-4107	138	12	neurotoxic	neurotoxic	JJ
en-wikipedia-org-4107	138	13	in	in	IN
en-wikipedia-org-4107	138	14	humans	human	NNS
en-wikipedia-org-4107	138	15	.	.	.
en-wikipedia-org-4107	139	1	[	[	-LRB-
en-wikipedia-org-4107	139	2	141][142	141][142	NNP
en-wikipedia-org-4107	139	3	]	]	-RRB-
en-wikipedia-org-4107	139	4	However	however	RB
en-wikipedia-org-4107	139	5	,	,	,
en-wikipedia-org-4107	139	6	large	large	JJ
en-wikipedia-org-4107	139	7	doses	dose	NNS
en-wikipedia-org-4107	139	8	of	of	IN
en-wikipedia-org-4107	139	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	139	10	may	may	MD
en-wikipedia-org-4107	139	11	indirectly	indirectly	RB
en-wikipedia-org-4107	139	12	cause	cause	VB
en-wikipedia-org-4107	139	13	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	139	14	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	139	15	as	as	IN
en-wikipedia-org-4107	139	16	a	a	DT
en-wikipedia-org-4107	139	17	result	result	NN
en-wikipedia-org-4107	139	18	of	of	IN
en-wikipedia-org-4107	139	19	hyperpyrexia	hyperpyrexia	NN
en-wikipedia-org-4107	139	20	,	,	,
en-wikipedia-org-4107	139	21	the	the	DT
en-wikipedia-org-4107	139	22	excessive	excessive	JJ
en-wikipedia-org-4107	139	23	formation	formation	NN
en-wikipedia-org-4107	139	24	of	of	IN
en-wikipedia-org-4107	139	25	reactive	reactive	JJ
en-wikipedia-org-4107	139	26	oxygen	oxygen	NN
en-wikipedia-org-4107	139	27	species	specie	NNS
en-wikipedia-org-4107	139	28	,	,	,
en-wikipedia-org-4107	139	29	and	and	CC
en-wikipedia-org-4107	139	30	increased	increase	VBN
en-wikipedia-org-4107	139	31	autoxidation	autoxidation	NN
en-wikipedia-org-4107	139	32	of	of	IN
en-wikipedia-org-4107	139	33	dopamine	dopamine	NN
en-wikipedia-org-4107	139	34	.	.	.
en-wikipedia-org-4107	140	1	[	[	-LRB-
en-wikipedia-org-4107	140	2	sources	source	NNS
en-wikipedia-org-4107	140	3	13	13	CD
en-wikipedia-org-4107	140	4	]	]	-RRB-
en-wikipedia-org-4107	140	5	Animal	animal	JJ
en-wikipedia-org-4107	140	6	models	model	NNS
en-wikipedia-org-4107	140	7	of	of	IN
en-wikipedia-org-4107	140	8	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	140	9	from	from	IN
en-wikipedia-org-4107	140	10	high	high	JJ
en-wikipedia-org-4107	140	11	-	-	HYPH
en-wikipedia-org-4107	140	12	dose	dose	NN
en-wikipedia-org-4107	140	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	140	14	exposure	exposure	NN
en-wikipedia-org-4107	140	15	indicate	indicate	VBP
en-wikipedia-org-4107	140	16	that	that	IN
en-wikipedia-org-4107	140	17	the	the	DT
en-wikipedia-org-4107	140	18	occurrence	occurrence	NN
en-wikipedia-org-4107	140	19	of	of	IN
en-wikipedia-org-4107	140	20	hyperpyrexia	hyperpyrexia	NNP
en-wikipedia-org-4107	140	21	(	(	-LRB-
en-wikipedia-org-4107	140	22	i.e.	i.e.	FW
en-wikipedia-org-4107	140	23	,	,	,
en-wikipedia-org-4107	140	24	core	core	NN
en-wikipedia-org-4107	140	25	body	body	NN
en-wikipedia-org-4107	140	26	temperature	temperature	NN
en-wikipedia-org-4107	140	27	 	  	_SP
en-wikipedia-org-4107	140	28	≥	≥	NN
en-wikipedia-org-4107	140	29	 	  	_SP
en-wikipedia-org-4107	140	30	40	40	CD
en-wikipedia-org-4107	140	31	 	  	_SP
en-wikipedia-org-4107	140	32	°	°	,
en-wikipedia-org-4107	140	33	C	C	NNP
en-wikipedia-org-4107	140	34	)	)	-RRB-
en-wikipedia-org-4107	140	35	is	be	VBZ
en-wikipedia-org-4107	140	36	necessary	necessary	JJ
en-wikipedia-org-4107	140	37	for	for	IN
en-wikipedia-org-4107	140	38	the	the	DT
en-wikipedia-org-4107	140	39	development	development	NN
en-wikipedia-org-4107	140	40	of	of	IN
en-wikipedia-org-4107	140	41	amphetamine	amphetamine	NN
en-wikipedia-org-4107	140	42	-	-	HYPH
en-wikipedia-org-4107	140	43	induced	induce	VBN
en-wikipedia-org-4107	140	44	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	140	45	.	.	.
en-wikipedia-org-4107	141	1	[	[	-LRB-
en-wikipedia-org-4107	141	2	140	140	CD
en-wikipedia-org-4107	141	3	]	]	-RRB-
en-wikipedia-org-4107	141	4	Prolonged	prolonged	JJ
en-wikipedia-org-4107	141	5	elevations	elevation	NNS
en-wikipedia-org-4107	141	6	of	of	IN
en-wikipedia-org-4107	141	7	brain	brain	NN
en-wikipedia-org-4107	141	8	temperature	temperature	NN
en-wikipedia-org-4107	141	9	above	above	IN
en-wikipedia-org-4107	141	10	40	40	CD
en-wikipedia-org-4107	141	11	 	  	_SP
en-wikipedia-org-4107	141	12	°	°	,
en-wikipedia-org-4107	141	13	C	C	NNP
en-wikipedia-org-4107	141	14	likely	likely	RB
en-wikipedia-org-4107	141	15	promote	promote	VB
en-wikipedia-org-4107	141	16	the	the	DT
en-wikipedia-org-4107	141	17	development	development	NN
en-wikipedia-org-4107	141	18	of	of	IN
en-wikipedia-org-4107	141	19	amphetamine	amphetamine	NN
en-wikipedia-org-4107	141	20	-	-	HYPH
en-wikipedia-org-4107	141	21	induced	induce	VBN
en-wikipedia-org-4107	141	22	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	141	23	in	in	IN
en-wikipedia-org-4107	141	24	laboratory	laboratory	NN
en-wikipedia-org-4107	141	25	animals	animal	NNS
en-wikipedia-org-4107	141	26	by	by	IN
en-wikipedia-org-4107	141	27	facilitating	facilitate	VBG
en-wikipedia-org-4107	141	28	the	the	DT
en-wikipedia-org-4107	141	29	production	production	NN
en-wikipedia-org-4107	141	30	of	of	IN
en-wikipedia-org-4107	141	31	reactive	reactive	JJ
en-wikipedia-org-4107	141	32	oxygen	oxygen	NN
en-wikipedia-org-4107	141	33	species	specie	NNS
en-wikipedia-org-4107	141	34	,	,	,
en-wikipedia-org-4107	141	35	disrupting	disrupt	VBG
en-wikipedia-org-4107	141	36	cellular	cellular	JJ
en-wikipedia-org-4107	141	37	protein	protein	NN
en-wikipedia-org-4107	141	38	function	function	NN
en-wikipedia-org-4107	141	39	,	,	,
en-wikipedia-org-4107	141	40	and	and	CC
en-wikipedia-org-4107	141	41	transiently	transiently	RB
en-wikipedia-org-4107	141	42	increasing	increase	VBG
en-wikipedia-org-4107	141	43	blood	blood	NN
en-wikipedia-org-4107	141	44	–	–	:
en-wikipedia-org-4107	141	45	brain	brain	NN
en-wikipedia-org-4107	141	46	barrier	barrier	NN
en-wikipedia-org-4107	141	47	permeability	permeability	NN
en-wikipedia-org-4107	141	48	.	.	.
en-wikipedia-org-4107	142	1	[	[	-LRB-
en-wikipedia-org-4107	142	2	140	140	CD
en-wikipedia-org-4107	142	3	]	]	-RRB-
en-wikipedia-org-4107	142	4	Psychosis	psychosis	NN
en-wikipedia-org-4107	142	5	See	see	VB
en-wikipedia-org-4107	142	6	also	also	RB
en-wikipedia-org-4107	142	7	:	:	:
en-wikipedia-org-4107	142	8	Stimulant	stimulant	NN
en-wikipedia-org-4107	142	9	psychosis	psychosis	NN
en-wikipedia-org-4107	142	10	An	an	DT
en-wikipedia-org-4107	142	11	amphetamine	amphetamine	NN
en-wikipedia-org-4107	142	12	overdose	overdose	WDT
en-wikipedia-org-4107	142	13	can	can	MD
en-wikipedia-org-4107	142	14	result	result	VB
en-wikipedia-org-4107	142	15	in	in	IN
en-wikipedia-org-4107	142	16	a	a	DT
en-wikipedia-org-4107	142	17	stimulant	stimulant	NN
en-wikipedia-org-4107	142	18	psychosis	psychosis	NN
en-wikipedia-org-4107	142	19	that	that	WDT
en-wikipedia-org-4107	142	20	may	may	MD
en-wikipedia-org-4107	142	21	involve	involve	VB
en-wikipedia-org-4107	142	22	a	a	DT
en-wikipedia-org-4107	142	23	variety	variety	NN
en-wikipedia-org-4107	142	24	of	of	IN
en-wikipedia-org-4107	142	25	symptoms	symptom	NNS
en-wikipedia-org-4107	142	26	,	,	,
en-wikipedia-org-4107	142	27	such	such	JJ
en-wikipedia-org-4107	142	28	as	as	IN
en-wikipedia-org-4107	142	29	delusions	delusion	NNS
en-wikipedia-org-4107	142	30	and	and	CC
en-wikipedia-org-4107	142	31	paranoia	paranoia	NN
en-wikipedia-org-4107	142	32	.	.	.
en-wikipedia-org-4107	143	1	[	[	-LRB-
en-wikipedia-org-4107	143	2	40][41	40][41	LS
en-wikipedia-org-4107	143	3	]	]	-RRB-
en-wikipedia-org-4107	143	4	A	a	DT
en-wikipedia-org-4107	143	5	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	143	6	review	review	NN
en-wikipedia-org-4107	143	7	on	on	IN
en-wikipedia-org-4107	143	8	treatment	treatment	NN
en-wikipedia-org-4107	143	9	for	for	IN
en-wikipedia-org-4107	143	10	amphetamine	amphetamine	NN
en-wikipedia-org-4107	143	11	,	,	,
en-wikipedia-org-4107	143	12	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	143	13	,	,	,
en-wikipedia-org-4107	143	14	and	and	CC
en-wikipedia-org-4107	143	15	methamphetamine	methamphetamine	JJ
en-wikipedia-org-4107	143	16	psychosis	psychosis	NN
en-wikipedia-org-4107	143	17	states	state	VBZ
en-wikipedia-org-4107	143	18	that	that	IN
en-wikipedia-org-4107	143	19	about	about	IN
en-wikipedia-org-4107	143	20	5–15	5–15	CD
en-wikipedia-org-4107	143	21	%	%	NN
en-wikipedia-org-4107	143	22	of	of	IN
en-wikipedia-org-4107	143	23	users	user	NNS
en-wikipedia-org-4107	143	24	fail	fail	VBP
en-wikipedia-org-4107	143	25	to	to	TO
en-wikipedia-org-4107	143	26	recover	recover	VB
en-wikipedia-org-4107	143	27	completely	completely	RB
en-wikipedia-org-4107	143	28	.	.	.
en-wikipedia-org-4107	144	1	[	[	-LRB-
en-wikipedia-org-4107	144	2	40][145	40][145	CD
en-wikipedia-org-4107	144	3	]	]	-RRB-
en-wikipedia-org-4107	144	4	According	accord	VBG
en-wikipedia-org-4107	144	5	to	to	IN
en-wikipedia-org-4107	144	6	the	the	DT
en-wikipedia-org-4107	144	7	same	same	JJ
en-wikipedia-org-4107	144	8	review	review	NN
en-wikipedia-org-4107	144	9	,	,	,
en-wikipedia-org-4107	144	10	there	there	EX
en-wikipedia-org-4107	144	11	is	be	VBZ
en-wikipedia-org-4107	144	12	at	at	RB
en-wikipedia-org-4107	144	13	least	least	RBS
en-wikipedia-org-4107	144	14	one	one	CD
en-wikipedia-org-4107	144	15	trial	trial	NN
en-wikipedia-org-4107	144	16	that	that	WDT
en-wikipedia-org-4107	144	17	shows	show	VBZ
en-wikipedia-org-4107	144	18	antipsychotic	antipsychotic	JJ
en-wikipedia-org-4107	144	19	medications	medication	NNS
en-wikipedia-org-4107	144	20	effectively	effectively	RB
en-wikipedia-org-4107	144	21	resolve	resolve	VB
en-wikipedia-org-4107	144	22	the	the	DT
en-wikipedia-org-4107	144	23	symptoms	symptom	NNS
en-wikipedia-org-4107	144	24	of	of	IN
en-wikipedia-org-4107	144	25	acute	acute	NNP
en-wikipedia-org-4107	144	26	amphetamine	amphetamine	NN
en-wikipedia-org-4107	144	27	psychosis	psychosis	NN
en-wikipedia-org-4107	144	28	.	.	.
en-wikipedia-org-4107	145	1	[	[	-LRB-
en-wikipedia-org-4107	145	2	40	40	CD
en-wikipedia-org-4107	145	3	]	]	-RRB-
en-wikipedia-org-4107	145	4	Psychosis	psychosis	NN
en-wikipedia-org-4107	145	5	rarely	rarely	RB
en-wikipedia-org-4107	145	6	arises	arise	VBZ
en-wikipedia-org-4107	145	7	from	from	IN
en-wikipedia-org-4107	145	8	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	145	9	use	use	NN
en-wikipedia-org-4107	145	10	.	.	.
en-wikipedia-org-4107	146	1	[	[	-LRB-
en-wikipedia-org-4107	146	2	28][41][42	28][41][42	CD
en-wikipedia-org-4107	146	3	]	]	-RRB-
en-wikipedia-org-4107	146	4	Drug	drug	NN
en-wikipedia-org-4107	146	5	interactions	interaction	NNS
en-wikipedia-org-4107	146	6	See	see	VB
en-wikipedia-org-4107	146	7	also	also	RB
en-wikipedia-org-4107	146	8	:	:	:
en-wikipedia-org-4107	146	9	Amphetamine	amphetamine	NN
en-wikipedia-org-4107	146	10	§	§	VBZ
en-wikipedia-org-4107	146	11	 	  	_SP
en-wikipedia-org-4107	146	12	Contraindications	contraindication	NNS
en-wikipedia-org-4107	146	13	,	,	,
en-wikipedia-org-4107	146	14	and	and	CC
en-wikipedia-org-4107	146	15	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	146	16	§	§	-LRB-
en-wikipedia-org-4107	146	17	 	  	_SP
en-wikipedia-org-4107	146	18	Pharmacokinetics	pharmacokinetic	NNS
en-wikipedia-org-4107	146	19	Many	many	JJ
en-wikipedia-org-4107	146	20	types	type	NNS
en-wikipedia-org-4107	146	21	of	of	IN
en-wikipedia-org-4107	146	22	substances	substance	NNS
en-wikipedia-org-4107	146	23	are	be	VBP
en-wikipedia-org-4107	146	24	known	know	VBN
en-wikipedia-org-4107	146	25	to	to	TO
en-wikipedia-org-4107	146	26	interact	interact	VB
en-wikipedia-org-4107	146	27	with	with	IN
en-wikipedia-org-4107	146	28	amphetamine	amphetamine	NN
en-wikipedia-org-4107	146	29	,	,	,
en-wikipedia-org-4107	146	30	resulting	result	VBG
en-wikipedia-org-4107	146	31	in	in	IN
en-wikipedia-org-4107	146	32	altered	alter	VBN
en-wikipedia-org-4107	146	33	drug	drug	NN
en-wikipedia-org-4107	146	34	action	action	NN
en-wikipedia-org-4107	146	35	or	or	CC
en-wikipedia-org-4107	146	36	metabolism	metabolism	NN
en-wikipedia-org-4107	146	37	of	of	IN
en-wikipedia-org-4107	146	38	amphetamine	amphetamine	NN
en-wikipedia-org-4107	146	39	,	,	,
en-wikipedia-org-4107	146	40	the	the	DT
en-wikipedia-org-4107	146	41	interacting	interact	VBG
en-wikipedia-org-4107	146	42	substance	substance	NN
en-wikipedia-org-4107	146	43	,	,	,
en-wikipedia-org-4107	146	44	or	or	CC
en-wikipedia-org-4107	146	45	both	both	DT
en-wikipedia-org-4107	146	46	.	.	.
en-wikipedia-org-4107	147	1	[	[	-LRB-
en-wikipedia-org-4107	147	2	28	28	CD
en-wikipedia-org-4107	147	3	]	]	-RRB-
en-wikipedia-org-4107	147	4	Inhibitors	inhibitor	NNS
en-wikipedia-org-4107	147	5	of	of	IN
en-wikipedia-org-4107	147	6	enzymes	enzyme	NNS
en-wikipedia-org-4107	147	7	that	that	WDT
en-wikipedia-org-4107	147	8	metabolize	metabolize	VBP
en-wikipedia-org-4107	147	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	147	10	(	(	-LRB-
en-wikipedia-org-4107	147	11	e.g.	e.g.	RB
en-wikipedia-org-4107	147	12	,	,	,
en-wikipedia-org-4107	147	13	CYP2D6	CYP2D6	NNP
en-wikipedia-org-4107	147	14	and	and	CC
en-wikipedia-org-4107	147	15	FMO3	FMO3	NNP
en-wikipedia-org-4107	147	16	)	)	-RRB-
en-wikipedia-org-4107	147	17	will	will	MD
en-wikipedia-org-4107	147	18	prolong	prolong	VB
en-wikipedia-org-4107	147	19	its	-PRON-	PRP$
en-wikipedia-org-4107	147	20	elimination	elimination	NN
en-wikipedia-org-4107	147	21	half	half	JJ
en-wikipedia-org-4107	147	22	-	-	HYPH
en-wikipedia-org-4107	147	23	life	life	NN
en-wikipedia-org-4107	147	24	,	,	,
en-wikipedia-org-4107	147	25	meaning	mean	VBG
en-wikipedia-org-4107	147	26	that	that	IN
en-wikipedia-org-4107	147	27	its	-PRON-	PRP$
en-wikipedia-org-4107	147	28	effects	effect	NNS
en-wikipedia-org-4107	147	29	will	will	MD
en-wikipedia-org-4107	147	30	last	last	VB
en-wikipedia-org-4107	147	31	longer	long	RBR
en-wikipedia-org-4107	147	32	.	.	.
en-wikipedia-org-4107	148	1	[	[	-LRB-
en-wikipedia-org-4107	148	2	16][28	16][28	CD
en-wikipedia-org-4107	148	3	]	]	-RRB-
en-wikipedia-org-4107	148	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	148	5	also	also	RB
en-wikipedia-org-4107	148	6	interacts	interact	VBZ
en-wikipedia-org-4107	148	7	with	with	IN
en-wikipedia-org-4107	148	8	MAOIs	maoi	NNS
en-wikipedia-org-4107	148	9	,	,	,
en-wikipedia-org-4107	148	10	particularly	particularly	RB
en-wikipedia-org-4107	148	11	monoamine	monoamine	NN
en-wikipedia-org-4107	148	12	oxidase	oxidase	NN
en-wikipedia-org-4107	148	13	A	a	DT
en-wikipedia-org-4107	148	14	inhibitors	inhibitor	NNS
en-wikipedia-org-4107	148	15	,	,	,
en-wikipedia-org-4107	148	16	since	since	IN
en-wikipedia-org-4107	148	17	both	both	CC
en-wikipedia-org-4107	148	18	MAOIs	maoi	NNS
en-wikipedia-org-4107	148	19	and	and	CC
en-wikipedia-org-4107	148	20	amphetamine	amphetamine	VB
en-wikipedia-org-4107	148	21	increase	increase	NN
en-wikipedia-org-4107	148	22	plasma	plasma	NNP
en-wikipedia-org-4107	148	23	catecholamines	catecholamines	NNP
en-wikipedia-org-4107	148	24	(	(	-LRB-
en-wikipedia-org-4107	148	25	i.e.	i.e.	FW
en-wikipedia-org-4107	148	26	,	,	,
en-wikipedia-org-4107	148	27	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	148	28	and	and	CC
en-wikipedia-org-4107	148	29	dopamine);[28	dopamine);[28	ADD
en-wikipedia-org-4107	148	30	]	]	-RRB-
en-wikipedia-org-4107	148	31	therefore	therefore	RB
en-wikipedia-org-4107	148	32	,	,	,
en-wikipedia-org-4107	148	33	concurrent	concurrent	JJ
en-wikipedia-org-4107	148	34	use	use	NN
en-wikipedia-org-4107	148	35	of	of	IN
en-wikipedia-org-4107	148	36	both	both	DT
en-wikipedia-org-4107	148	37	is	be	VBZ
en-wikipedia-org-4107	148	38	dangerous	dangerous	JJ
en-wikipedia-org-4107	148	39	.	.	.
en-wikipedia-org-4107	149	1	[	[	-LRB-
en-wikipedia-org-4107	149	2	28	28	CD
en-wikipedia-org-4107	149	3	]	]	-RRB-
en-wikipedia-org-4107	149	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	149	5	modulates	modulate	VBZ
en-wikipedia-org-4107	149	6	the	the	DT
en-wikipedia-org-4107	149	7	activity	activity	NN
en-wikipedia-org-4107	149	8	of	of	IN
en-wikipedia-org-4107	149	9	most	most	JJS
en-wikipedia-org-4107	149	10	psychoactive	psychoactive	JJ
en-wikipedia-org-4107	149	11	drugs	drug	NNS
en-wikipedia-org-4107	149	12	.	.	.
en-wikipedia-org-4107	150	1	In	in	IN
en-wikipedia-org-4107	150	2	particular	particular	JJ
en-wikipedia-org-4107	150	3	,	,	,
en-wikipedia-org-4107	150	4	amphetamine	amphetamine	NN
en-wikipedia-org-4107	150	5	may	may	MD
en-wikipedia-org-4107	150	6	decrease	decrease	VB
en-wikipedia-org-4107	150	7	the	the	DT
en-wikipedia-org-4107	150	8	effects	effect	NNS
en-wikipedia-org-4107	150	9	of	of	IN
en-wikipedia-org-4107	150	10	sedatives	sedative	NNS
en-wikipedia-org-4107	150	11	and	and	CC
en-wikipedia-org-4107	150	12	depressants	depressant	NNS
en-wikipedia-org-4107	150	13	and	and	CC
en-wikipedia-org-4107	150	14	increase	increase	VB
en-wikipedia-org-4107	150	15	the	the	DT
en-wikipedia-org-4107	150	16	effects	effect	NNS
en-wikipedia-org-4107	150	17	of	of	IN
en-wikipedia-org-4107	150	18	stimulants	stimulant	NNS
en-wikipedia-org-4107	150	19	and	and	CC
en-wikipedia-org-4107	150	20	antidepressants	antidepressant	NNS
en-wikipedia-org-4107	150	21	.	.	.
en-wikipedia-org-4107	151	1	[	[	-LRB-
en-wikipedia-org-4107	151	2	28	28	CD
en-wikipedia-org-4107	151	3	]	]	-RRB-
en-wikipedia-org-4107	151	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	151	5	may	may	MD
en-wikipedia-org-4107	151	6	also	also	RB
en-wikipedia-org-4107	151	7	decrease	decrease	VB
en-wikipedia-org-4107	151	8	the	the	DT
en-wikipedia-org-4107	151	9	effects	effect	NNS
en-wikipedia-org-4107	151	10	of	of	IN
en-wikipedia-org-4107	151	11	antihypertensives	antihypertensive	NNS
en-wikipedia-org-4107	151	12	and	and	CC
en-wikipedia-org-4107	151	13	antipsychotics	antipsychotic	NNS
en-wikipedia-org-4107	151	14	due	due	JJ
en-wikipedia-org-4107	151	15	to	to	IN
en-wikipedia-org-4107	151	16	its	-PRON-	PRP$
en-wikipedia-org-4107	151	17	effects	effect	NNS
en-wikipedia-org-4107	151	18	on	on	IN
en-wikipedia-org-4107	151	19	blood	blood	NN
en-wikipedia-org-4107	151	20	pressure	pressure	NN
en-wikipedia-org-4107	151	21	and	and	CC
en-wikipedia-org-4107	151	22	dopamine	dopamine	NN
en-wikipedia-org-4107	151	23	respectively	respectively	RB
en-wikipedia-org-4107	151	24	.	.	.
en-wikipedia-org-4107	152	1	[	[	-LRB-
en-wikipedia-org-4107	152	2	28	28	CD
en-wikipedia-org-4107	152	3	]	]	-RRB-
en-wikipedia-org-4107	152	4	Zinc	Zinc	NNP
en-wikipedia-org-4107	152	5	supplementation	supplementation	NN
en-wikipedia-org-4107	152	6	may	may	MD
en-wikipedia-org-4107	152	7	reduce	reduce	VB
en-wikipedia-org-4107	152	8	the	the	DT
en-wikipedia-org-4107	152	9	minimum	minimum	JJ
en-wikipedia-org-4107	152	10	effective	effective	JJ
en-wikipedia-org-4107	152	11	dose	dose	NN
en-wikipedia-org-4107	152	12	of	of	IN
en-wikipedia-org-4107	152	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	152	14	when	when	WRB
en-wikipedia-org-4107	152	15	it	-PRON-	PRP
en-wikipedia-org-4107	152	16	is	be	VBZ
en-wikipedia-org-4107	152	17	used	use	VBN
en-wikipedia-org-4107	152	18	for	for	IN
en-wikipedia-org-4107	152	19	the	the	DT
en-wikipedia-org-4107	152	20	treatment	treatment	NN
en-wikipedia-org-4107	152	21	of	of	IN
en-wikipedia-org-4107	152	22	ADHD	ADHD	NNP
en-wikipedia-org-4107	152	23	.	.	.
en-wikipedia-org-4107	153	1	[	[	-LRB-
en-wikipedia-org-4107	153	2	note	note	NN
en-wikipedia-org-4107	153	3	16][150	16][150	ADD
en-wikipedia-org-4107	153	4	]	]	-RRB-
en-wikipedia-org-4107	153	5	In	in	IN
en-wikipedia-org-4107	153	6	general	general	JJ
en-wikipedia-org-4107	153	7	,	,	,
en-wikipedia-org-4107	153	8	there	there	EX
en-wikipedia-org-4107	153	9	is	be	VBZ
en-wikipedia-org-4107	153	10	no	no	DT
en-wikipedia-org-4107	153	11	significant	significant	JJ
en-wikipedia-org-4107	153	12	interaction	interaction	NN
en-wikipedia-org-4107	153	13	when	when	WRB
en-wikipedia-org-4107	153	14	consuming	consume	VBG
en-wikipedia-org-4107	153	15	amphetamine	amphetamine	NN
en-wikipedia-org-4107	153	16	with	with	IN
en-wikipedia-org-4107	153	17	food	food	NN
en-wikipedia-org-4107	153	18	,	,	,
en-wikipedia-org-4107	153	19	but	but	CC
en-wikipedia-org-4107	153	20	the	the	DT
en-wikipedia-org-4107	153	21	pH	pH	NNP
en-wikipedia-org-4107	153	22	of	of	IN
en-wikipedia-org-4107	153	23	gastrointestinal	gastrointestinal	JJ
en-wikipedia-org-4107	153	24	content	content	NN
en-wikipedia-org-4107	153	25	and	and	CC
en-wikipedia-org-4107	153	26	urine	urine	NN
en-wikipedia-org-4107	153	27	affects	affect	VBZ
en-wikipedia-org-4107	153	28	the	the	DT
en-wikipedia-org-4107	153	29	absorption	absorption	NN
en-wikipedia-org-4107	153	30	and	and	CC
en-wikipedia-org-4107	153	31	excretion	excretion	NN
en-wikipedia-org-4107	153	32	of	of	IN
en-wikipedia-org-4107	153	33	amphetamine	amphetamine	NN
en-wikipedia-org-4107	153	34	,	,	,
en-wikipedia-org-4107	153	35	respectively	respectively	RB
en-wikipedia-org-4107	153	36	.	.	.
en-wikipedia-org-4107	154	1	[	[	-LRB-
en-wikipedia-org-4107	154	2	28	28	CD
en-wikipedia-org-4107	154	3	]	]	-RRB-
en-wikipedia-org-4107	154	4	Acidic	acidic	JJ
en-wikipedia-org-4107	154	5	substances	substance	NNS
en-wikipedia-org-4107	154	6	reduce	reduce	VBP
en-wikipedia-org-4107	154	7	the	the	DT
en-wikipedia-org-4107	154	8	absorption	absorption	NN
en-wikipedia-org-4107	154	9	of	of	IN
en-wikipedia-org-4107	154	10	amphetamine	amphetamine	NN
en-wikipedia-org-4107	154	11	and	and	CC
en-wikipedia-org-4107	154	12	increase	increase	VB
en-wikipedia-org-4107	154	13	urinary	urinary	JJ
en-wikipedia-org-4107	154	14	excretion	excretion	NN
en-wikipedia-org-4107	154	15	,	,	,
en-wikipedia-org-4107	154	16	and	and	CC
en-wikipedia-org-4107	154	17	alkaline	alkaline	NN
en-wikipedia-org-4107	154	18	substances	substance	NNS
en-wikipedia-org-4107	154	19	do	do	VBP
en-wikipedia-org-4107	154	20	the	the	DT
en-wikipedia-org-4107	154	21	opposite	opposite	NN
en-wikipedia-org-4107	154	22	.	.	.
en-wikipedia-org-4107	155	1	[	[	-LRB-
en-wikipedia-org-4107	155	2	28	28	CD
en-wikipedia-org-4107	155	3	]	]	-RRB-
en-wikipedia-org-4107	155	4	Due	due	IN
en-wikipedia-org-4107	155	5	to	to	IN
en-wikipedia-org-4107	155	6	the	the	DT
en-wikipedia-org-4107	155	7	effect	effect	NN
en-wikipedia-org-4107	155	8	pH	pH	NNP
en-wikipedia-org-4107	155	9	has	have	VBZ
en-wikipedia-org-4107	155	10	on	on	IN
en-wikipedia-org-4107	155	11	absorption	absorption	NN
en-wikipedia-org-4107	155	12	,	,	,
en-wikipedia-org-4107	155	13	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	155	14	also	also	RB
en-wikipedia-org-4107	155	15	interacts	interact	VBZ
en-wikipedia-org-4107	155	16	with	with	IN
en-wikipedia-org-4107	155	17	gastric	gastric	JJ
en-wikipedia-org-4107	155	18	acid	acid	NN
en-wikipedia-org-4107	155	19	reducers	reducer	NNS
en-wikipedia-org-4107	155	20	such	such	JJ
en-wikipedia-org-4107	155	21	as	as	IN
en-wikipedia-org-4107	155	22	proton	proton	NNP
en-wikipedia-org-4107	155	23	pump	pump	NN
en-wikipedia-org-4107	155	24	inhibitors	inhibitor	NNS
en-wikipedia-org-4107	155	25	and	and	CC
en-wikipedia-org-4107	155	26	H2	H2	NNP
en-wikipedia-org-4107	155	27	antihistamines	antihistamine	NNS
en-wikipedia-org-4107	155	28	,	,	,
en-wikipedia-org-4107	155	29	which	which	WDT
en-wikipedia-org-4107	155	30	increase	increase	VBP
en-wikipedia-org-4107	155	31	gastrointestinal	gastrointestinal	JJ
en-wikipedia-org-4107	155	32	pH	ph	NN
en-wikipedia-org-4107	155	33	(	(	-LRB-
en-wikipedia-org-4107	155	34	i.e.	i.e.	FW
en-wikipedia-org-4107	155	35	,	,	,
en-wikipedia-org-4107	155	36	make	make	VB
en-wikipedia-org-4107	155	37	it	-PRON-	PRP
en-wikipedia-org-4107	155	38	less	less	RBR
en-wikipedia-org-4107	155	39	acidic	acidic	JJ
en-wikipedia-org-4107	155	40	)	)	-RRB-
en-wikipedia-org-4107	155	41	.	.	.
en-wikipedia-org-4107	156	1	[	[	-LRB-
en-wikipedia-org-4107	156	2	28	28	CD
en-wikipedia-org-4107	156	3	]	]	-RRB-
en-wikipedia-org-4107	156	4	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	156	5	Pharmacodynamics	Pharmacodynamics	NNP
en-wikipedia-org-4107	156	6	For	for	IN
en-wikipedia-org-4107	156	7	a	a	DT
en-wikipedia-org-4107	156	8	simpler	simple	JJR
en-wikipedia-org-4107	156	9	and	and	CC
en-wikipedia-org-4107	156	10	less	less	RBR
en-wikipedia-org-4107	156	11	technical	technical	JJ
en-wikipedia-org-4107	156	12	explanation	explanation	NN
en-wikipedia-org-4107	156	13	of	of	IN
en-wikipedia-org-4107	156	14	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	156	15	's	's	POS
en-wikipedia-org-4107	156	16	mechanism	mechanism	NN
en-wikipedia-org-4107	156	17	of	of	IN
en-wikipedia-org-4107	156	18	action	action	NN
en-wikipedia-org-4107	156	19	,	,	,
en-wikipedia-org-4107	156	20	see	see	VB
en-wikipedia-org-4107	156	21	Adderall	Adderall	NNP
en-wikipedia-org-4107	156	22	§	§	NFP
en-wikipedia-org-4107	156	23	 	  	_SP
en-wikipedia-org-4107	156	24	Mechanism	mechanism	NN
en-wikipedia-org-4107	156	25	of	of	IN
en-wikipedia-org-4107	156	26	action	action	NN
en-wikipedia-org-4107	156	27	.	.	.
en-wikipedia-org-4107	157	1	Pharmacodynamics	pharmacodynamic	NNS
en-wikipedia-org-4107	157	2	of	of	IN
en-wikipedia-org-4107	157	3	amphetamine	amphetamine	NN
en-wikipedia-org-4107	157	4	in	in	IN
en-wikipedia-org-4107	157	5	a	a	DT
en-wikipedia-org-4107	157	6	dopamine	dopamine	NN
en-wikipedia-org-4107	157	7	neuron	neuron	NN
en-wikipedia-org-4107	157	8	v	v	NNP
en-wikipedia-org-4107	157	9	t	t	NNP
en-wikipedia-org-4107	157	10	e	e	NNP
en-wikipedia-org-4107	157	11	via	via	IN
en-wikipedia-org-4107	157	12	AADC	AADC	NNP
en-wikipedia-org-4107	157	13	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	157	14	enters	enter	VBZ
en-wikipedia-org-4107	157	15	the	the	DT
en-wikipedia-org-4107	157	16	presynaptic	presynaptic	JJ
en-wikipedia-org-4107	157	17	neuron	neuron	NN
en-wikipedia-org-4107	157	18	across	across	IN
en-wikipedia-org-4107	157	19	the	the	DT
en-wikipedia-org-4107	157	20	neuronal	neuronal	JJ
en-wikipedia-org-4107	157	21	membrane	membrane	NN
en-wikipedia-org-4107	157	22	or	or	CC
en-wikipedia-org-4107	157	23	through	through	IN
en-wikipedia-org-4107	157	24	DAT	DAT	NNP
en-wikipedia-org-4107	157	25	.	.	.
en-wikipedia-org-4107	158	1	[	[	-LRB-
en-wikipedia-org-4107	158	2	37	37	CD
en-wikipedia-org-4107	158	3	]	]	-RRB-
en-wikipedia-org-4107	158	4	Once	once	RB
en-wikipedia-org-4107	158	5	inside	inside	RB
en-wikipedia-org-4107	158	6	,	,	,
en-wikipedia-org-4107	158	7	it	-PRON-	PRP
en-wikipedia-org-4107	158	8	binds	bind	VBZ
en-wikipedia-org-4107	158	9	to	to	IN
en-wikipedia-org-4107	158	10	TAAR1	taar1	NN
en-wikipedia-org-4107	158	11	or	or	CC
en-wikipedia-org-4107	158	12	enters	enter	VBZ
en-wikipedia-org-4107	158	13	synaptic	synaptic	JJ
en-wikipedia-org-4107	158	14	vesicles	vesicle	NNS
en-wikipedia-org-4107	158	15	through	through	IN
en-wikipedia-org-4107	158	16	VMAT2	VMAT2	NNS
en-wikipedia-org-4107	158	17	.	.	.
en-wikipedia-org-4107	159	1	[	[	-LRB-
en-wikipedia-org-4107	159	2	37][151	37][151	LS
en-wikipedia-org-4107	159	3	]	]	-RRB-
en-wikipedia-org-4107	159	4	When	when	WRB
en-wikipedia-org-4107	159	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	159	6	enters	enter	VBZ
en-wikipedia-org-4107	159	7	synaptic	synaptic	JJ
en-wikipedia-org-4107	159	8	vesicles	vesicle	NNS
en-wikipedia-org-4107	159	9	through	through	IN
en-wikipedia-org-4107	159	10	VMAT2	VMAT2	NNS
en-wikipedia-org-4107	159	11	,	,	,
en-wikipedia-org-4107	159	12	it	-PRON-	PRP
en-wikipedia-org-4107	159	13	collapses	collapse	VBZ
en-wikipedia-org-4107	159	14	the	the	DT
en-wikipedia-org-4107	159	15	vesicular	vesicular	JJ
en-wikipedia-org-4107	159	16	pH	pH	NNP
en-wikipedia-org-4107	159	17	gradient	gradient	NN
en-wikipedia-org-4107	159	18	,	,	,
en-wikipedia-org-4107	159	19	which	which	WDT
en-wikipedia-org-4107	159	20	in	in	IN
en-wikipedia-org-4107	159	21	turn	turn	NN
en-wikipedia-org-4107	159	22	causes	cause	VBZ
en-wikipedia-org-4107	159	23	dopamine	dopamine	NN
en-wikipedia-org-4107	159	24	to	to	TO
en-wikipedia-org-4107	159	25	be	be	VB
en-wikipedia-org-4107	159	26	released	release	VBN
en-wikipedia-org-4107	159	27	into	into	IN
en-wikipedia-org-4107	159	28	the	the	DT
en-wikipedia-org-4107	159	29	cytosol	cytosol	NN
en-wikipedia-org-4107	159	30	(	(	-LRB-
en-wikipedia-org-4107	159	31	light	light	JJ
en-wikipedia-org-4107	159	32	tan	tan	JJ
en-wikipedia-org-4107	159	33	-	-	HYPH
en-wikipedia-org-4107	159	34	colored	colored	JJ
en-wikipedia-org-4107	159	35	area	area	NN
en-wikipedia-org-4107	159	36	)	)	-RRB-
en-wikipedia-org-4107	159	37	through	through	IN
en-wikipedia-org-4107	159	38	VMAT2	VMAT2	NNS
en-wikipedia-org-4107	159	39	.	.	.
en-wikipedia-org-4107	160	1	[	[	-LRB-
en-wikipedia-org-4107	160	2	151][152	151][152	CD
en-wikipedia-org-4107	160	3	]	]	-RRB-
en-wikipedia-org-4107	160	4	When	when	WRB
en-wikipedia-org-4107	160	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	160	6	binds	bind	NNS
en-wikipedia-org-4107	160	7	to	to	IN
en-wikipedia-org-4107	160	8	TAAR1	taar1	NN
en-wikipedia-org-4107	160	9	,	,	,
en-wikipedia-org-4107	160	10	it	-PRON-	PRP
en-wikipedia-org-4107	160	11	reduces	reduce	VBZ
en-wikipedia-org-4107	160	12	the	the	DT
en-wikipedia-org-4107	160	13	firing	firing	NN
en-wikipedia-org-4107	160	14	rate	rate	NN
en-wikipedia-org-4107	160	15	of	of	IN
en-wikipedia-org-4107	160	16	the	the	DT
en-wikipedia-org-4107	160	17	dopamine	dopamine	NN
en-wikipedia-org-4107	160	18	neuron	neuron	NN
en-wikipedia-org-4107	160	19	via	via	IN
en-wikipedia-org-4107	160	20	potassium	potassium	NN
en-wikipedia-org-4107	160	21	channels	channel	NNS
en-wikipedia-org-4107	160	22	and	and	CC
en-wikipedia-org-4107	160	23	activates	activate	VBZ
en-wikipedia-org-4107	160	24	protein	protein	NN
en-wikipedia-org-4107	160	25	kinase	kinase	VBD
en-wikipedia-org-4107	160	26	A	a	DT
en-wikipedia-org-4107	160	27	(	(	-LRB-
en-wikipedia-org-4107	160	28	PKA	PKA	NNP
en-wikipedia-org-4107	160	29	)	)	-RRB-
en-wikipedia-org-4107	160	30	and	and	CC
en-wikipedia-org-4107	160	31	protein	protein	NN
en-wikipedia-org-4107	160	32	kinase	kinase	NNP
en-wikipedia-org-4107	160	33	C	C	NNP
en-wikipedia-org-4107	160	34	(	(	-LRB-
en-wikipedia-org-4107	160	35	PKC	PKC	NNP
en-wikipedia-org-4107	160	36	)	)	-RRB-
en-wikipedia-org-4107	160	37	,	,	,
en-wikipedia-org-4107	160	38	which	which	WDT
en-wikipedia-org-4107	160	39	subsequently	subsequently	RB
en-wikipedia-org-4107	160	40	phosphorylates	phosphorylate	VBZ
en-wikipedia-org-4107	160	41	DAT	DAT	NNP
en-wikipedia-org-4107	160	42	.	.	.
en-wikipedia-org-4107	161	1	[	[	-LRB-
en-wikipedia-org-4107	161	2	37][153][154	37][153][154	NN
en-wikipedia-org-4107	161	3	]	]	-RRB-
en-wikipedia-org-4107	161	4	PKA	pka	NN
en-wikipedia-org-4107	161	5	-	-	HYPH
en-wikipedia-org-4107	161	6	phosphorylation	phosphorylation	NN
en-wikipedia-org-4107	161	7	causes	cause	VBZ
en-wikipedia-org-4107	161	8	DAT	DAT	NNP
en-wikipedia-org-4107	161	9	to	to	TO
en-wikipedia-org-4107	161	10	withdraw	withdraw	VB
en-wikipedia-org-4107	161	11	into	into	IN
en-wikipedia-org-4107	161	12	the	the	DT
en-wikipedia-org-4107	161	13	presynaptic	presynaptic	JJ
en-wikipedia-org-4107	161	14	neuron	neuron	NN
en-wikipedia-org-4107	161	15	(	(	-LRB-
en-wikipedia-org-4107	161	16	internalize	internalize	NN
en-wikipedia-org-4107	161	17	)	)	-RRB-
en-wikipedia-org-4107	161	18	and	and	CC
en-wikipedia-org-4107	161	19	cease	cease	NN
en-wikipedia-org-4107	161	20	transport	transport	NN
en-wikipedia-org-4107	161	21	.	.	.
en-wikipedia-org-4107	162	1	[	[	-LRB-
en-wikipedia-org-4107	162	2	37	37	CD
en-wikipedia-org-4107	162	3	]	]	-RRB-
en-wikipedia-org-4107	162	4	PKC	pkc	NN
en-wikipedia-org-4107	162	5	-	-	HYPH
en-wikipedia-org-4107	162	6	phosphorylated	phosphorylate	VBN
en-wikipedia-org-4107	162	7	DAT	DAT	NNP
en-wikipedia-org-4107	162	8	may	may	MD
en-wikipedia-org-4107	162	9	either	either	CC
en-wikipedia-org-4107	162	10	operate	operate	VB
en-wikipedia-org-4107	162	11	in	in	IN
en-wikipedia-org-4107	162	12	reverse	reverse	NN
en-wikipedia-org-4107	162	13	or	or	CC
en-wikipedia-org-4107	162	14	,	,	,
en-wikipedia-org-4107	162	15	like	like	IN
en-wikipedia-org-4107	162	16	PKA	PKA	NNP
en-wikipedia-org-4107	162	17	-	-	HYPH
en-wikipedia-org-4107	162	18	phosphorylated	phosphorylate	VBN
en-wikipedia-org-4107	162	19	DAT	DAT	NNP
en-wikipedia-org-4107	162	20	,	,	,
en-wikipedia-org-4107	162	21	internalize	internalize	NN
en-wikipedia-org-4107	162	22	and	and	CC
en-wikipedia-org-4107	162	23	cease	cease	VB
en-wikipedia-org-4107	162	24	transport	transport	NN
en-wikipedia-org-4107	162	25	.	.	.
en-wikipedia-org-4107	163	1	[	[	-LRB-
en-wikipedia-org-4107	163	2	37	37	CD
en-wikipedia-org-4107	163	3	]	]	-RRB-
en-wikipedia-org-4107	163	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	163	5	is	be	VBZ
en-wikipedia-org-4107	163	6	also	also	RB
en-wikipedia-org-4107	163	7	known	know	VBN
en-wikipedia-org-4107	163	8	to	to	TO
en-wikipedia-org-4107	163	9	increase	increase	VB
en-wikipedia-org-4107	163	10	intracellular	intracellular	JJ
en-wikipedia-org-4107	163	11	calcium	calcium	NN
en-wikipedia-org-4107	163	12	,	,	,
en-wikipedia-org-4107	163	13	an	an	DT
en-wikipedia-org-4107	163	14	effect	effect	NN
en-wikipedia-org-4107	163	15	which	which	WDT
en-wikipedia-org-4107	163	16	is	be	VBZ
en-wikipedia-org-4107	163	17	associated	associate	VBN
en-wikipedia-org-4107	163	18	with	with	IN
en-wikipedia-org-4107	163	19	DAT	DAT	NNP
en-wikipedia-org-4107	163	20	phosphorylation	phosphorylation	NN
en-wikipedia-org-4107	163	21	through	through	IN
en-wikipedia-org-4107	163	22	a	a	DT
en-wikipedia-org-4107	163	23	CAMKIIα	CAMKIIα	NNP
en-wikipedia-org-4107	163	24	-	-	HYPH
en-wikipedia-org-4107	163	25	dependent	dependent	JJ
en-wikipedia-org-4107	163	26	pathway	pathway	NN
en-wikipedia-org-4107	163	27	,	,	,
en-wikipedia-org-4107	163	28	in	in	IN
en-wikipedia-org-4107	163	29	turn	turn	NN
en-wikipedia-org-4107	163	30	producing	produce	VBG
en-wikipedia-org-4107	163	31	dopamine	dopamine	NN
en-wikipedia-org-4107	163	32	efflux	efflux	JJ
en-wikipedia-org-4107	163	33	.	.	.
en-wikipedia-org-4107	164	1	[	[	-LRB-
en-wikipedia-org-4107	164	2	155][156	155][156	LS
en-wikipedia-org-4107	164	3	]	]	-RRB-
en-wikipedia-org-4107	164	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	164	5	exerts	exert	VBZ
en-wikipedia-org-4107	164	6	its	-PRON-	PRP$
en-wikipedia-org-4107	164	7	behavioral	behavioral	JJ
en-wikipedia-org-4107	164	8	effects	effect	NNS
en-wikipedia-org-4107	164	9	by	by	IN
en-wikipedia-org-4107	164	10	altering	alter	VBG
en-wikipedia-org-4107	164	11	the	the	DT
en-wikipedia-org-4107	164	12	use	use	NN
en-wikipedia-org-4107	164	13	of	of	IN
en-wikipedia-org-4107	164	14	monoamines	monoamine	NNS
en-wikipedia-org-4107	164	15	as	as	IN
en-wikipedia-org-4107	164	16	neuronal	neuronal	JJ
en-wikipedia-org-4107	164	17	signals	signal	NNS
en-wikipedia-org-4107	164	18	in	in	IN
en-wikipedia-org-4107	164	19	the	the	DT
en-wikipedia-org-4107	164	20	brain	brain	NN
en-wikipedia-org-4107	164	21	,	,	,
en-wikipedia-org-4107	164	22	primarily	primarily	RB
en-wikipedia-org-4107	164	23	in	in	IN
en-wikipedia-org-4107	164	24	catecholamine	catecholamine	NN
en-wikipedia-org-4107	164	25	neurons	neuron	NNS
en-wikipedia-org-4107	164	26	in	in	IN
en-wikipedia-org-4107	164	27	the	the	DT
en-wikipedia-org-4107	164	28	reward	reward	NN
en-wikipedia-org-4107	164	29	and	and	CC
en-wikipedia-org-4107	164	30	executive	executive	JJ
en-wikipedia-org-4107	164	31	function	function	NN
en-wikipedia-org-4107	164	32	pathways	pathway	NNS
en-wikipedia-org-4107	164	33	of	of	IN
en-wikipedia-org-4107	164	34	the	the	DT
en-wikipedia-org-4107	164	35	brain	brain	NN
en-wikipedia-org-4107	164	36	.	.	.
en-wikipedia-org-4107	165	1	[	[	-LRB-
en-wikipedia-org-4107	165	2	37][58	37][58	CD
en-wikipedia-org-4107	165	3	]	]	-RRB-
en-wikipedia-org-4107	165	4	The	the	DT
en-wikipedia-org-4107	165	5	concentrations	concentration	NNS
en-wikipedia-org-4107	165	6	of	of	IN
en-wikipedia-org-4107	165	7	the	the	DT
en-wikipedia-org-4107	165	8	main	main	JJ
en-wikipedia-org-4107	165	9	neurotransmitters	neurotransmitter	NNS
en-wikipedia-org-4107	165	10	involved	involve	VBN
en-wikipedia-org-4107	165	11	in	in	IN
en-wikipedia-org-4107	165	12	reward	reward	NN
en-wikipedia-org-4107	165	13	circuitry	circuitry	NN
en-wikipedia-org-4107	165	14	and	and	CC
en-wikipedia-org-4107	165	15	executive	executive	NN
en-wikipedia-org-4107	165	16	functioning	functioning	NN
en-wikipedia-org-4107	165	17	,	,	,
en-wikipedia-org-4107	165	18	dopamine	dopamine	NN
en-wikipedia-org-4107	165	19	and	and	CC
en-wikipedia-org-4107	165	20	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	165	21	,	,	,
en-wikipedia-org-4107	165	22	increase	increase	VB
en-wikipedia-org-4107	165	23	dramatically	dramatically	RB
en-wikipedia-org-4107	165	24	in	in	IN
en-wikipedia-org-4107	165	25	a	a	DT
en-wikipedia-org-4107	165	26	dose	dose	RB
en-wikipedia-org-4107	165	27	-	-	HYPH
en-wikipedia-org-4107	165	28	dependent	dependent	JJ
en-wikipedia-org-4107	165	29	manner	manner	NN
en-wikipedia-org-4107	165	30	by	by	IN
en-wikipedia-org-4107	165	31	amphetamine	amphetamine	NN
en-wikipedia-org-4107	165	32	because	because	IN
en-wikipedia-org-4107	165	33	of	of	IN
en-wikipedia-org-4107	165	34	its	-PRON-	PRP$
en-wikipedia-org-4107	165	35	effects	effect	NNS
en-wikipedia-org-4107	165	36	on	on	IN
en-wikipedia-org-4107	165	37	monoamine	monoamine	NN
en-wikipedia-org-4107	165	38	transporters	transporter	NNS
en-wikipedia-org-4107	165	39	.	.	.
en-wikipedia-org-4107	166	1	[	[	-LRB-
en-wikipedia-org-4107	166	2	37][58][151	37][58][151	CD
en-wikipedia-org-4107	166	3	]	]	-RRB-
en-wikipedia-org-4107	166	4	The	the	DT
en-wikipedia-org-4107	166	5	reinforcing	reinforce	VBG
en-wikipedia-org-4107	166	6	and	and	CC
en-wikipedia-org-4107	166	7	motivational	motivational	JJ
en-wikipedia-org-4107	166	8	salience	salience	NN
en-wikipedia-org-4107	166	9	-	-	HYPH
en-wikipedia-org-4107	166	10	promoting	promote	VBG
en-wikipedia-org-4107	166	11	effects	effect	NNS
en-wikipedia-org-4107	166	12	of	of	IN
en-wikipedia-org-4107	166	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	166	14	are	be	VBP
en-wikipedia-org-4107	166	15	due	due	JJ
en-wikipedia-org-4107	166	16	mostly	mostly	RB
en-wikipedia-org-4107	166	17	to	to	IN
en-wikipedia-org-4107	166	18	enhanced	enhance	VBN
en-wikipedia-org-4107	166	19	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	166	20	activity	activity	NN
en-wikipedia-org-4107	166	21	in	in	IN
en-wikipedia-org-4107	166	22	the	the	DT
en-wikipedia-org-4107	166	23	mesolimbic	mesolimbic	JJ
en-wikipedia-org-4107	166	24	pathway	pathway	NN
en-wikipedia-org-4107	166	25	.	.	.
en-wikipedia-org-4107	167	1	[	[	-LRB-
en-wikipedia-org-4107	167	2	26	26	CD
en-wikipedia-org-4107	167	3	]	]	-RRB-
en-wikipedia-org-4107	167	4	The	the	DT
en-wikipedia-org-4107	167	5	euphoric	euphoric	JJ
en-wikipedia-org-4107	167	6	and	and	CC
en-wikipedia-org-4107	167	7	locomotor	locomotor	NN
en-wikipedia-org-4107	167	8	-	-	HYPH
en-wikipedia-org-4107	167	9	stimulating	stimulate	VBG
en-wikipedia-org-4107	167	10	effects	effect	NNS
en-wikipedia-org-4107	167	11	of	of	IN
en-wikipedia-org-4107	167	12	amphetamine	amphetamine	NN
en-wikipedia-org-4107	167	13	are	be	VBP
en-wikipedia-org-4107	167	14	dependent	dependent	JJ
en-wikipedia-org-4107	167	15	upon	upon	IN
en-wikipedia-org-4107	167	16	the	the	DT
en-wikipedia-org-4107	167	17	magnitude	magnitude	NN
en-wikipedia-org-4107	167	18	and	and	CC
en-wikipedia-org-4107	167	19	speed	speed	NN
en-wikipedia-org-4107	167	20	by	by	IN
en-wikipedia-org-4107	167	21	which	which	WDT
en-wikipedia-org-4107	167	22	it	-PRON-	PRP
en-wikipedia-org-4107	167	23	increases	increase	VBZ
en-wikipedia-org-4107	167	24	synaptic	synaptic	JJ
en-wikipedia-org-4107	167	25	dopamine	dopamine	NN
en-wikipedia-org-4107	167	26	and	and	CC
en-wikipedia-org-4107	167	27	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	167	28	concentrations	concentration	NNS
en-wikipedia-org-4107	167	29	in	in	IN
en-wikipedia-org-4107	167	30	the	the	DT
en-wikipedia-org-4107	167	31	striatum	striatum	NN
en-wikipedia-org-4107	167	32	.	.	.
en-wikipedia-org-4107	168	1	[	[	-LRB-
en-wikipedia-org-4107	168	2	3	3	LS
en-wikipedia-org-4107	168	3	]	]	-RRB-
en-wikipedia-org-4107	168	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	168	5	has	have	VBZ
en-wikipedia-org-4107	168	6	been	be	VBN
en-wikipedia-org-4107	168	7	identified	identify	VBN
en-wikipedia-org-4107	168	8	as	as	IN
en-wikipedia-org-4107	168	9	a	a	DT
en-wikipedia-org-4107	168	10	potent	potent	JJ
en-wikipedia-org-4107	168	11	full	full	JJ
en-wikipedia-org-4107	168	12	agonist	agonist	NN
en-wikipedia-org-4107	168	13	of	of	IN
en-wikipedia-org-4107	168	14	trace	trace	NN
en-wikipedia-org-4107	168	15	amine	amine	NN
en-wikipedia-org-4107	168	16	-	-	HYPH
en-wikipedia-org-4107	168	17	associated	associate	VBN
en-wikipedia-org-4107	168	18	receptor	receptor	NNP
en-wikipedia-org-4107	168	19	1	1	CD
en-wikipedia-org-4107	168	20	(	(	-LRB-
en-wikipedia-org-4107	168	21	TAAR1	taar1	NN
en-wikipedia-org-4107	168	22	)	)	-RRB-
en-wikipedia-org-4107	168	23	,	,	,
en-wikipedia-org-4107	168	24	a	a	DT
en-wikipedia-org-4107	168	25	Gs	Gs	NNP
en-wikipedia-org-4107	168	26	-	-	HYPH
en-wikipedia-org-4107	168	27	coupled	couple	VBN
en-wikipedia-org-4107	168	28	and	and	CC
en-wikipedia-org-4107	168	29	Gq	Gq	NNP
en-wikipedia-org-4107	168	30	-	-	HYPH
en-wikipedia-org-4107	168	31	coupled	couple	VBN
en-wikipedia-org-4107	168	32	G	G	NNP
en-wikipedia-org-4107	168	33	protein	protein	NN
en-wikipedia-org-4107	168	34	-	-	HYPH
en-wikipedia-org-4107	168	35	coupled	couple	VBN
en-wikipedia-org-4107	168	36	receptor	receptor	NN
en-wikipedia-org-4107	168	37	(	(	-LRB-
en-wikipedia-org-4107	168	38	GPCR	GPCR	NNP
en-wikipedia-org-4107	168	39	)	)	-RRB-
en-wikipedia-org-4107	168	40	discovered	discover	VBD
en-wikipedia-org-4107	168	41	in	in	IN
en-wikipedia-org-4107	168	42	2001	2001	CD
en-wikipedia-org-4107	168	43	,	,	,
en-wikipedia-org-4107	168	44	which	which	WDT
en-wikipedia-org-4107	168	45	is	be	VBZ
en-wikipedia-org-4107	168	46	important	important	JJ
en-wikipedia-org-4107	168	47	for	for	IN
en-wikipedia-org-4107	168	48	regulation	regulation	NN
en-wikipedia-org-4107	168	49	of	of	IN
en-wikipedia-org-4107	168	50	brain	brain	NN
en-wikipedia-org-4107	168	51	monoamines	monoamine	NNS
en-wikipedia-org-4107	168	52	.	.	.
en-wikipedia-org-4107	169	1	[	[	-LRB-
en-wikipedia-org-4107	169	2	37][157	37][157	NFP
en-wikipedia-org-4107	169	3	]	]	-RRB-
en-wikipedia-org-4107	169	4	Activation	activation	NN
en-wikipedia-org-4107	169	5	of	of	IN
en-wikipedia-org-4107	169	6	TAAR1	taar1	NN
en-wikipedia-org-4107	169	7	increases	increase	NNS
en-wikipedia-org-4107	169	8	cAMP	camp	NN
en-wikipedia-org-4107	169	9	production	production	NN
en-wikipedia-org-4107	169	10	via	via	IN
en-wikipedia-org-4107	169	11	adenylyl	adenylyl	NNP
en-wikipedia-org-4107	169	12	cyclase	cyclase	NNP
en-wikipedia-org-4107	169	13	activation	activation	NNP
en-wikipedia-org-4107	169	14	and	and	CC
en-wikipedia-org-4107	169	15	inhibits	inhibit	VBZ
en-wikipedia-org-4107	169	16	monoamine	monoamine	NNP
en-wikipedia-org-4107	169	17	transporter	transporter	NN
en-wikipedia-org-4107	169	18	function	function	NN
en-wikipedia-org-4107	169	19	.	.	.
en-wikipedia-org-4107	170	1	[	[	-LRB-
en-wikipedia-org-4107	170	2	37][158	37][158	NNP
en-wikipedia-org-4107	170	3	]	]	-RRB-
en-wikipedia-org-4107	170	4	Monoamine	Monoamine	NNP
en-wikipedia-org-4107	170	5	autoreceptors	autoreceptor	NNS
en-wikipedia-org-4107	170	6	(	(	-LRB-
en-wikipedia-org-4107	170	7	e.g.	e.g.	RB
en-wikipedia-org-4107	170	8	,	,	,
en-wikipedia-org-4107	170	9	D2	D2	NNP
en-wikipedia-org-4107	170	10	short	short	JJ
en-wikipedia-org-4107	170	11	,	,	,
en-wikipedia-org-4107	170	12	presynaptic	presynaptic	JJ
en-wikipedia-org-4107	170	13	α2	α2	NNP
en-wikipedia-org-4107	170	14	,	,	,
en-wikipedia-org-4107	170	15	and	and	CC
en-wikipedia-org-4107	170	16	presynaptic	presynaptic	JJ
en-wikipedia-org-4107	170	17	5-HT1A	5-ht1a	NN
en-wikipedia-org-4107	170	18	)	)	-RRB-
en-wikipedia-org-4107	170	19	have	have	VBP
en-wikipedia-org-4107	170	20	the	the	DT
en-wikipedia-org-4107	170	21	opposite	opposite	JJ
en-wikipedia-org-4107	170	22	effect	effect	NN
en-wikipedia-org-4107	170	23	of	of	IN
en-wikipedia-org-4107	170	24	TAAR1	taar1	NN
en-wikipedia-org-4107	170	25	,	,	,
en-wikipedia-org-4107	170	26	and	and	CC
en-wikipedia-org-4107	170	27	together	together	RB
en-wikipedia-org-4107	170	28	these	these	DT
en-wikipedia-org-4107	170	29	receptors	receptor	NNS
en-wikipedia-org-4107	170	30	provide	provide	VBP
en-wikipedia-org-4107	170	31	a	a	DT
en-wikipedia-org-4107	170	32	regulatory	regulatory	JJ
en-wikipedia-org-4107	170	33	system	system	NN
en-wikipedia-org-4107	170	34	for	for	IN
en-wikipedia-org-4107	170	35	monoamines	monoamine	NNS
en-wikipedia-org-4107	170	36	.	.	.
en-wikipedia-org-4107	171	1	[	[	-LRB-
en-wikipedia-org-4107	171	2	37][38	37][38	CD
en-wikipedia-org-4107	171	3	]	]	-RRB-
en-wikipedia-org-4107	171	4	Notably	notably	RB
en-wikipedia-org-4107	171	5	,	,	,
en-wikipedia-org-4107	171	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	171	7	and	and	CC
en-wikipedia-org-4107	171	8	trace	trace	NN
en-wikipedia-org-4107	171	9	amines	amine	NNS
en-wikipedia-org-4107	171	10	possess	possess	VBP
en-wikipedia-org-4107	171	11	high	high	JJ
en-wikipedia-org-4107	171	12	binding	bind	VBG
en-wikipedia-org-4107	171	13	affinities	affinity	NNS
en-wikipedia-org-4107	171	14	for	for	IN
en-wikipedia-org-4107	171	15	TAAR1	taar1	NN
en-wikipedia-org-4107	171	16	,	,	,
en-wikipedia-org-4107	171	17	but	but	CC
en-wikipedia-org-4107	171	18	not	not	RB
en-wikipedia-org-4107	171	19	for	for	IN
en-wikipedia-org-4107	171	20	monoamine	monoamine	NN
en-wikipedia-org-4107	171	21	autoreceptors	autoreceptor	NNS
en-wikipedia-org-4107	171	22	.	.	.
en-wikipedia-org-4107	172	1	[	[	-LRB-
en-wikipedia-org-4107	172	2	37][38	37][38	CD
en-wikipedia-org-4107	172	3	]	]	-RRB-
en-wikipedia-org-4107	172	4	Imaging	Imaging	NNP
en-wikipedia-org-4107	172	5	studies	study	NNS
en-wikipedia-org-4107	172	6	indicate	indicate	VBP
en-wikipedia-org-4107	172	7	that	that	IN
en-wikipedia-org-4107	172	8	monoamine	monoamine	NN
en-wikipedia-org-4107	172	9	reuptake	reuptake	NN
en-wikipedia-org-4107	172	10	inhibition	inhibition	NN
en-wikipedia-org-4107	172	11	by	by	IN
en-wikipedia-org-4107	172	12	amphetamine	amphetamine	NN
en-wikipedia-org-4107	172	13	and	and	CC
en-wikipedia-org-4107	172	14	trace	trace	NN
en-wikipedia-org-4107	172	15	amines	amine	NNS
en-wikipedia-org-4107	172	16	is	be	VBZ
en-wikipedia-org-4107	172	17	site	site	NN
en-wikipedia-org-4107	172	18	specific	specific	JJ
en-wikipedia-org-4107	172	19	and	and	CC
en-wikipedia-org-4107	172	20	depends	depend	VBZ
en-wikipedia-org-4107	172	21	upon	upon	IN
en-wikipedia-org-4107	172	22	the	the	DT
en-wikipedia-org-4107	172	23	presence	presence	NN
en-wikipedia-org-4107	172	24	of	of	IN
en-wikipedia-org-4107	172	25	TAAR1	taar1	NN
en-wikipedia-org-4107	172	26	co	co	NN
en-wikipedia-org-4107	172	27	-	-	NN
en-wikipedia-org-4107	172	28	localization	localization	NN
en-wikipedia-org-4107	172	29	in	in	IN
en-wikipedia-org-4107	172	30	the	the	DT
en-wikipedia-org-4107	172	31	associated	associated	NNP
en-wikipedia-org-4107	172	32	monoamine	monoamine	NNP
en-wikipedia-org-4107	172	33	neurons	neuron	NNS
en-wikipedia-org-4107	172	34	.	.	.
en-wikipedia-org-4107	173	1	[	[	-LRB-
en-wikipedia-org-4107	173	2	37	37	CD
en-wikipedia-org-4107	173	3	]	]	-RRB-
en-wikipedia-org-4107	173	4	In	in	IN
en-wikipedia-org-4107	173	5	addition	addition	NN
en-wikipedia-org-4107	173	6	to	to	IN
en-wikipedia-org-4107	173	7	the	the	DT
en-wikipedia-org-4107	173	8	neuronal	neuronal	JJ
en-wikipedia-org-4107	173	9	monoamine	monoamine	NN
en-wikipedia-org-4107	173	10	transporters	transporter	NNS
en-wikipedia-org-4107	173	11	,	,	,
en-wikipedia-org-4107	173	12	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	173	13	also	also	RB
en-wikipedia-org-4107	173	14	inhibits	inhibit	VBZ
en-wikipedia-org-4107	173	15	both	both	CC
en-wikipedia-org-4107	173	16	vesicular	vesicular	JJ
en-wikipedia-org-4107	173	17	monoamine	monoamine	NN
en-wikipedia-org-4107	173	18	transporters	transporter	NNS
en-wikipedia-org-4107	173	19	,	,	,
en-wikipedia-org-4107	173	20	VMAT1	VMAT1	NNP
en-wikipedia-org-4107	173	21	and	and	CC
en-wikipedia-org-4107	173	22	VMAT2	VMAT2	NNS
en-wikipedia-org-4107	173	23	,	,	,
en-wikipedia-org-4107	173	24	as	as	RB
en-wikipedia-org-4107	173	25	well	well	RB
en-wikipedia-org-4107	173	26	as	as	IN
en-wikipedia-org-4107	173	27	SLC1A1	slc1a1	CD
en-wikipedia-org-4107	173	28	,	,	,
en-wikipedia-org-4107	173	29	SLC22A3	slc22a3	NN
en-wikipedia-org-4107	173	30	,	,	,
en-wikipedia-org-4107	173	31	and	and	CC
en-wikipedia-org-4107	173	32	SLC22A5	slc22a5	NN
en-wikipedia-org-4107	173	33	.	.	.
en-wikipedia-org-4107	174	1	[	[	-LRB-
en-wikipedia-org-4107	174	2	sources	source	NNS
en-wikipedia-org-4107	174	3	14	14	CD
en-wikipedia-org-4107	174	4	]	]	-RRB-
en-wikipedia-org-4107	174	5	SLC1A1	slc1a1	CD
en-wikipedia-org-4107	174	6	is	be	VBZ
en-wikipedia-org-4107	174	7	excitatory	excitatory	NN
en-wikipedia-org-4107	174	8	amino	amino	NN
en-wikipedia-org-4107	174	9	acid	acid	NN
en-wikipedia-org-4107	174	10	transporter	transporter	NN
en-wikipedia-org-4107	174	11	3	3	CD
en-wikipedia-org-4107	174	12	(	(	-LRB-
en-wikipedia-org-4107	174	13	EAAT3	eaat3	UH
en-wikipedia-org-4107	174	14	)	)	-RRB-
en-wikipedia-org-4107	174	15	,	,	,
en-wikipedia-org-4107	174	16	a	a	DT
en-wikipedia-org-4107	174	17	glutamate	glutamate	JJ
en-wikipedia-org-4107	174	18	transporter	transporter	NN
en-wikipedia-org-4107	174	19	located	locate	VBN
en-wikipedia-org-4107	174	20	in	in	IN
en-wikipedia-org-4107	174	21	neurons	neuron	NNS
en-wikipedia-org-4107	174	22	,	,	,
en-wikipedia-org-4107	174	23	SLC22A3	SLC22A3	NNP
en-wikipedia-org-4107	174	24	is	be	VBZ
en-wikipedia-org-4107	174	25	an	an	DT
en-wikipedia-org-4107	174	26	extraneuronal	extraneuronal	JJ
en-wikipedia-org-4107	174	27	monoamine	monoamine	NN
en-wikipedia-org-4107	174	28	transporter	transporter	NN
en-wikipedia-org-4107	174	29	that	that	WDT
en-wikipedia-org-4107	174	30	is	be	VBZ
en-wikipedia-org-4107	174	31	present	present	JJ
en-wikipedia-org-4107	174	32	in	in	IN
en-wikipedia-org-4107	174	33	astrocytes	astrocyte	NNS
en-wikipedia-org-4107	174	34	,	,	,
en-wikipedia-org-4107	174	35	and	and	CC
en-wikipedia-org-4107	174	36	SLC22A5	slc22a5	NN
en-wikipedia-org-4107	174	37	is	be	VBZ
en-wikipedia-org-4107	174	38	a	a	DT
en-wikipedia-org-4107	174	39	high	high	JJ
en-wikipedia-org-4107	174	40	-	-	HYPH
en-wikipedia-org-4107	174	41	affinity	affinity	NN
en-wikipedia-org-4107	174	42	carnitine	carnitine	NN
en-wikipedia-org-4107	174	43	transporter	transporter	NN
en-wikipedia-org-4107	174	44	.	.	.
en-wikipedia-org-4107	175	1	[	[	-LRB-
en-wikipedia-org-4107	175	2	sources	source	NNS
en-wikipedia-org-4107	175	3	14	14	CD
en-wikipedia-org-4107	175	4	]	]	-RRB-
en-wikipedia-org-4107	175	5	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	175	6	is	be	VBZ
en-wikipedia-org-4107	175	7	known	know	VBN
en-wikipedia-org-4107	175	8	to	to	TO
en-wikipedia-org-4107	175	9	strongly	strongly	RB
en-wikipedia-org-4107	175	10	induce	induce	VB
en-wikipedia-org-4107	175	11	cocaine-	cocaine-	JJ
en-wikipedia-org-4107	175	12	and	and	CC
en-wikipedia-org-4107	175	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	175	14	-	-	HYPH
en-wikipedia-org-4107	175	15	regulated	regulate	VBN
en-wikipedia-org-4107	175	16	transcript	transcript	NN
en-wikipedia-org-4107	175	17	(	(	-LRB-
en-wikipedia-org-4107	175	18	CART	CART	NNP
en-wikipedia-org-4107	175	19	)	)	-RRB-
en-wikipedia-org-4107	175	20	gene	gene	NN
en-wikipedia-org-4107	175	21	expression,[5][164	expression,[5][164	NNP
en-wikipedia-org-4107	175	22	]	]	-RRB-
en-wikipedia-org-4107	175	23	a	a	DT
en-wikipedia-org-4107	175	24	neuropeptide	neuropeptide	NN
en-wikipedia-org-4107	175	25	involved	involve	VBN
en-wikipedia-org-4107	175	26	in	in	IN
en-wikipedia-org-4107	175	27	feeding	feed	VBG
en-wikipedia-org-4107	175	28	behavior	behavior	NN
en-wikipedia-org-4107	175	29	,	,	,
en-wikipedia-org-4107	175	30	stress	stress	NN
en-wikipedia-org-4107	175	31	,	,	,
en-wikipedia-org-4107	175	32	and	and	CC
en-wikipedia-org-4107	175	33	reward	reward	NN
en-wikipedia-org-4107	175	34	,	,	,
en-wikipedia-org-4107	175	35	which	which	WDT
en-wikipedia-org-4107	175	36	induces	induce	VBZ
en-wikipedia-org-4107	175	37	observable	observable	JJ
en-wikipedia-org-4107	175	38	increases	increase	NNS
en-wikipedia-org-4107	175	39	in	in	IN
en-wikipedia-org-4107	175	40	neuronal	neuronal	JJ
en-wikipedia-org-4107	175	41	development	development	NN
en-wikipedia-org-4107	175	42	and	and	CC
en-wikipedia-org-4107	175	43	survival	survival	NN
en-wikipedia-org-4107	175	44	in	in	IN
en-wikipedia-org-4107	175	45	vitro	vitro	FW
en-wikipedia-org-4107	175	46	.	.	.
en-wikipedia-org-4107	176	1	[	[	-LRB-
en-wikipedia-org-4107	176	2	5][165][166	5][165][166	CD
en-wikipedia-org-4107	176	3	]	]	-RRB-
en-wikipedia-org-4107	176	4	The	the	DT
en-wikipedia-org-4107	176	5	CART	CART	NNP
en-wikipedia-org-4107	176	6	receptor	receptor	NN
en-wikipedia-org-4107	176	7	has	have	VBZ
en-wikipedia-org-4107	176	8	yet	yet	RB
en-wikipedia-org-4107	176	9	to	to	TO
en-wikipedia-org-4107	176	10	be	be	VB
en-wikipedia-org-4107	176	11	identified	identify	VBN
en-wikipedia-org-4107	176	12	,	,	,
en-wikipedia-org-4107	176	13	but	but	CC
en-wikipedia-org-4107	176	14	there	there	EX
en-wikipedia-org-4107	176	15	is	be	VBZ
en-wikipedia-org-4107	176	16	significant	significant	JJ
en-wikipedia-org-4107	176	17	evidence	evidence	NN
en-wikipedia-org-4107	176	18	that	that	IN
en-wikipedia-org-4107	176	19	CART	CART	NNP
en-wikipedia-org-4107	176	20	binds	bind	VBZ
en-wikipedia-org-4107	176	21	to	to	IN
en-wikipedia-org-4107	176	22	a	a	DT
en-wikipedia-org-4107	176	23	unique	unique	JJ
en-wikipedia-org-4107	176	24	Gi	Gi	NNP
en-wikipedia-org-4107	176	25	/	/	SYM
en-wikipedia-org-4107	176	26	Go	go	VB
en-wikipedia-org-4107	176	27	-	-	HYPH
en-wikipedia-org-4107	176	28	coupled	couple	VBN
en-wikipedia-org-4107	176	29	GPCR	GPCR	NNP
en-wikipedia-org-4107	176	30	.	.	.
en-wikipedia-org-4107	177	1	[	[	-LRB-
en-wikipedia-org-4107	177	2	166][167	166][167	LS
en-wikipedia-org-4107	177	3	]	]	-RRB-
en-wikipedia-org-4107	177	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	177	5	also	also	RB
en-wikipedia-org-4107	177	6	inhibits	inhibit	VBZ
en-wikipedia-org-4107	177	7	monoamine	monoamine	NN
en-wikipedia-org-4107	177	8	oxidases	oxidase	NNS
en-wikipedia-org-4107	177	9	at	at	IN
en-wikipedia-org-4107	177	10	very	very	RB
en-wikipedia-org-4107	177	11	high	high	JJ
en-wikipedia-org-4107	177	12	doses	dose	NNS
en-wikipedia-org-4107	177	13	,	,	,
en-wikipedia-org-4107	177	14	resulting	result	VBG
en-wikipedia-org-4107	177	15	in	in	IN
en-wikipedia-org-4107	177	16	less	less	JJR
en-wikipedia-org-4107	177	17	monoamine	monoamine	NN
en-wikipedia-org-4107	177	18	and	and	CC
en-wikipedia-org-4107	177	19	trace	trace	NN
en-wikipedia-org-4107	177	20	amine	amine	NNP
en-wikipedia-org-4107	177	21	metabolism	metabolism	NN
en-wikipedia-org-4107	177	22	and	and	CC
en-wikipedia-org-4107	177	23	consequently	consequently	RB
en-wikipedia-org-4107	177	24	higher	high	JJR
en-wikipedia-org-4107	177	25	concentrations	concentration	NNS
en-wikipedia-org-4107	177	26	of	of	IN
en-wikipedia-org-4107	177	27	synaptic	synaptic	JJ
en-wikipedia-org-4107	177	28	monoamines	monoamine	NNS
en-wikipedia-org-4107	177	29	.	.	.
en-wikipedia-org-4107	178	1	[	[	-LRB-
en-wikipedia-org-4107	178	2	22][168	22][168	LS
en-wikipedia-org-4107	178	3	]	]	-RRB-
en-wikipedia-org-4107	178	4	In	in	IN
en-wikipedia-org-4107	178	5	humans	human	NNS
en-wikipedia-org-4107	178	6	,	,	,
en-wikipedia-org-4107	178	7	the	the	DT
en-wikipedia-org-4107	178	8	only	only	JJ
en-wikipedia-org-4107	178	9	post	post	JJ
en-wikipedia-org-4107	178	10	-	-	JJ
en-wikipedia-org-4107	178	11	synaptic	synaptic	JJ
en-wikipedia-org-4107	178	12	receptor	receptor	NN
en-wikipedia-org-4107	178	13	at	at	IN
en-wikipedia-org-4107	178	14	which	which	WDT
en-wikipedia-org-4107	178	15	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	178	16	is	be	VBZ
en-wikipedia-org-4107	178	17	known	know	VBN
en-wikipedia-org-4107	178	18	to	to	TO
en-wikipedia-org-4107	178	19	bind	bind	VB
en-wikipedia-org-4107	178	20	is	be	VBZ
en-wikipedia-org-4107	178	21	the	the	DT
en-wikipedia-org-4107	178	22	5-HT1A	5-ht1a	JJ
en-wikipedia-org-4107	178	23	receptor	receptor	NN
en-wikipedia-org-4107	178	24	,	,	,
en-wikipedia-org-4107	178	25	where	where	WRB
en-wikipedia-org-4107	178	26	it	-PRON-	PRP
en-wikipedia-org-4107	178	27	acts	act	VBZ
en-wikipedia-org-4107	178	28	as	as	IN
en-wikipedia-org-4107	178	29	an	an	DT
en-wikipedia-org-4107	178	30	agonist	agonist	NN
en-wikipedia-org-4107	178	31	with	with	IN
en-wikipedia-org-4107	178	32	low	low	JJ
en-wikipedia-org-4107	178	33	micromolar	micromolar	JJ
en-wikipedia-org-4107	178	34	affinity	affinity	NN
en-wikipedia-org-4107	178	35	.	.	.
en-wikipedia-org-4107	179	1	[	[	-LRB-
en-wikipedia-org-4107	179	2	169][170	169][170	LS
en-wikipedia-org-4107	179	3	]	]	-RRB-
en-wikipedia-org-4107	179	4	The	the	DT
en-wikipedia-org-4107	179	5	full	full	JJ
en-wikipedia-org-4107	179	6	profile	profile	NN
en-wikipedia-org-4107	179	7	of	of	IN
en-wikipedia-org-4107	179	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	179	9	's	's	POS
en-wikipedia-org-4107	179	10	short	short	JJ
en-wikipedia-org-4107	179	11	-	-	HYPH
en-wikipedia-org-4107	179	12	term	term	NN
en-wikipedia-org-4107	179	13	drug	drug	NN
en-wikipedia-org-4107	179	14	effects	effect	NNS
en-wikipedia-org-4107	179	15	in	in	IN
en-wikipedia-org-4107	179	16	humans	human	NNS
en-wikipedia-org-4107	179	17	is	be	VBZ
en-wikipedia-org-4107	179	18	mostly	mostly	RB
en-wikipedia-org-4107	179	19	derived	derive	VBN
en-wikipedia-org-4107	179	20	through	through	IN
en-wikipedia-org-4107	179	21	increased	increase	VBN
en-wikipedia-org-4107	179	22	cellular	cellular	JJ
en-wikipedia-org-4107	179	23	communication	communication	NN
en-wikipedia-org-4107	179	24	or	or	CC
en-wikipedia-org-4107	179	25	neurotransmission	neurotransmission	NN
en-wikipedia-org-4107	179	26	of	of	IN
en-wikipedia-org-4107	179	27	dopamine,[37	dopamine,[37	CD
en-wikipedia-org-4107	179	28	]	]	-RRB-
en-wikipedia-org-4107	179	29	serotonin,[37	serotonin,[37	CD
en-wikipedia-org-4107	179	30	]	]	-RRB-
en-wikipedia-org-4107	179	31	norepinephrine,[37	norepinephrine,[37	NN
en-wikipedia-org-4107	179	32	]	]	-RRB-
en-wikipedia-org-4107	179	33	epinephrine,[151	epinephrine,[151	NN
en-wikipedia-org-4107	179	34	]	]	-RRB-
en-wikipedia-org-4107	179	35	histamine,[151	histamine,[151	NN
en-wikipedia-org-4107	179	36	]	]	-RRB-
en-wikipedia-org-4107	179	37	CART	CART	NNP
en-wikipedia-org-4107	179	38	peptides,[5][164	peptides,[5][164	NNP
en-wikipedia-org-4107	179	39	]	]	-RRB-
en-wikipedia-org-4107	179	40	endogenous	endogenous	JJ
en-wikipedia-org-4107	179	41	opioids,[171][172][173	opioids,[171][172][173	NNP
en-wikipedia-org-4107	179	42	]	]	-RRB-
en-wikipedia-org-4107	179	43	adrenocorticotropic	adrenocorticotropic	JJ
en-wikipedia-org-4107	179	44	hormone,[174][175	hormone,[174][175	NN
en-wikipedia-org-4107	179	45	]	]	-RRB-
en-wikipedia-org-4107	179	46	corticosteroids,[174][175	corticosteroids,[174][175	NNP
en-wikipedia-org-4107	179	47	]	]	-RRB-
en-wikipedia-org-4107	179	48	and	and	CC
en-wikipedia-org-4107	179	49	glutamate,[155][160	glutamate,[155][160	NNP
en-wikipedia-org-4107	179	50	]	]	-RRB-
en-wikipedia-org-4107	179	51	which	which	WDT
en-wikipedia-org-4107	179	52	it	-PRON-	PRP
en-wikipedia-org-4107	179	53	effects	effect	VBZ
en-wikipedia-org-4107	179	54	through	through	IN
en-wikipedia-org-4107	179	55	interactions	interaction	NNS
en-wikipedia-org-4107	179	56	with	with	IN
en-wikipedia-org-4107	179	57	CART	CART	NNP
en-wikipedia-org-4107	179	58	,	,	,
en-wikipedia-org-4107	179	59	5-HT1A	5-ht1a	CD
en-wikipedia-org-4107	179	60	,	,	,
en-wikipedia-org-4107	179	61	EAAT3	eaat3	UH
en-wikipedia-org-4107	179	62	,	,	,
en-wikipedia-org-4107	179	63	TAAR1	taar1	NN
en-wikipedia-org-4107	179	64	,	,	,
en-wikipedia-org-4107	179	65	VMAT1	VMAT1	NNP
en-wikipedia-org-4107	179	66	,	,	,
en-wikipedia-org-4107	179	67	VMAT2	vmat2	NN
en-wikipedia-org-4107	179	68	,	,	,
en-wikipedia-org-4107	179	69	and	and	CC
en-wikipedia-org-4107	179	70	possibly	possibly	RB
en-wikipedia-org-4107	179	71	other	other	JJ
en-wikipedia-org-4107	179	72	biological	biological	JJ
en-wikipedia-org-4107	179	73	targets	target	NNS
en-wikipedia-org-4107	179	74	.	.	.
en-wikipedia-org-4107	180	1	[	[	-LRB-
en-wikipedia-org-4107	180	2	sources	source	NNS
en-wikipedia-org-4107	180	3	15	15	CD
en-wikipedia-org-4107	180	4	]	]	-RRB-
en-wikipedia-org-4107	180	5	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	180	6	also	also	RB
en-wikipedia-org-4107	180	7	activates	activate	VBZ
en-wikipedia-org-4107	180	8	seven	seven	CD
en-wikipedia-org-4107	180	9	human	human	JJ
en-wikipedia-org-4107	180	10	carbonic	carbonic	JJ
en-wikipedia-org-4107	180	11	anhydrase	anhydrase	NN
en-wikipedia-org-4107	180	12	enzymes	enzyme	NNS
en-wikipedia-org-4107	180	13	,	,	,
en-wikipedia-org-4107	180	14	several	several	JJ
en-wikipedia-org-4107	180	15	of	of	IN
en-wikipedia-org-4107	180	16	which	which	WDT
en-wikipedia-org-4107	180	17	are	be	VBP
en-wikipedia-org-4107	180	18	expressed	express	VBN
en-wikipedia-org-4107	180	19	in	in	IN
en-wikipedia-org-4107	180	20	the	the	DT
en-wikipedia-org-4107	180	21	human	human	JJ
en-wikipedia-org-4107	180	22	brain	brain	NN
en-wikipedia-org-4107	180	23	.	.	.
en-wikipedia-org-4107	181	1	[	[	-LRB-
en-wikipedia-org-4107	181	2	176	176	CD
en-wikipedia-org-4107	181	3	]	]	-RRB-
en-wikipedia-org-4107	181	4	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	181	5	is	be	VBZ
en-wikipedia-org-4107	181	6	a	a	DT
en-wikipedia-org-4107	181	7	more	more	RBR
en-wikipedia-org-4107	181	8	potent	potent	JJ
en-wikipedia-org-4107	181	9	agonist	agonist	NN
en-wikipedia-org-4107	181	10	of	of	IN
en-wikipedia-org-4107	181	11	TAAR1	TAAR1	NNP
en-wikipedia-org-4107	181	12	than	than	IN
en-wikipedia-org-4107	181	13	levoamphetamine	levoamphetamine	NN
en-wikipedia-org-4107	181	14	.	.	.
en-wikipedia-org-4107	182	1	[	[	-LRB-
en-wikipedia-org-4107	182	2	177	177	CD
en-wikipedia-org-4107	182	3	]	]	-RRB-
en-wikipedia-org-4107	182	4	Consequently	consequently	RB
en-wikipedia-org-4107	182	5	,	,	,
en-wikipedia-org-4107	182	6	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	182	7	produces	produce	VBZ
en-wikipedia-org-4107	182	8	greater	great	JJR
en-wikipedia-org-4107	182	9	CNS	cns	NN
en-wikipedia-org-4107	182	10	stimulation	stimulation	NN
en-wikipedia-org-4107	182	11	than	than	IN
en-wikipedia-org-4107	182	12	levoamphetamine	levoamphetamine	NN
en-wikipedia-org-4107	182	13	,	,	,
en-wikipedia-org-4107	182	14	roughly	roughly	RB
en-wikipedia-org-4107	182	15	three	three	CD
en-wikipedia-org-4107	182	16	to	to	TO
en-wikipedia-org-4107	182	17	four	four	CD
en-wikipedia-org-4107	182	18	times	time	NNS
en-wikipedia-org-4107	182	19	more	more	JJR
en-wikipedia-org-4107	182	20	,	,	,
en-wikipedia-org-4107	182	21	but	but	CC
en-wikipedia-org-4107	182	22	levoamphetamine	levoamphetamine	NNP
en-wikipedia-org-4107	182	23	has	have	VBZ
en-wikipedia-org-4107	182	24	slightly	slightly	RB
en-wikipedia-org-4107	182	25	stronger	strong	JJR
en-wikipedia-org-4107	182	26	cardiovascular	cardiovascular	JJ
en-wikipedia-org-4107	182	27	and	and	CC
en-wikipedia-org-4107	182	28	peripheral	peripheral	JJ
en-wikipedia-org-4107	182	29	effects	effect	NNS
en-wikipedia-org-4107	182	30	.	.	.
en-wikipedia-org-4107	183	1	[	[	-LRB-
en-wikipedia-org-4107	183	2	39][177	39][177	NNP
en-wikipedia-org-4107	183	3	]	]	-RRB-
en-wikipedia-org-4107	183	4	Dopamine	Dopamine	NNP
en-wikipedia-org-4107	183	5	In	in	IN
en-wikipedia-org-4107	183	6	certain	certain	JJ
en-wikipedia-org-4107	183	7	brain	brain	NN
en-wikipedia-org-4107	183	8	regions	region	NNS
en-wikipedia-org-4107	183	9	,	,	,
en-wikipedia-org-4107	183	10	amphetamine	amphetamine	NN
en-wikipedia-org-4107	183	11	increases	increase	VBZ
en-wikipedia-org-4107	183	12	the	the	DT
en-wikipedia-org-4107	183	13	concentration	concentration	NN
en-wikipedia-org-4107	183	14	of	of	IN
en-wikipedia-org-4107	183	15	dopamine	dopamine	NN
en-wikipedia-org-4107	183	16	in	in	IN
en-wikipedia-org-4107	183	17	the	the	DT
en-wikipedia-org-4107	183	18	synaptic	synaptic	JJ
en-wikipedia-org-4107	183	19	cleft	cleft	NN
en-wikipedia-org-4107	183	20	.	.	.
en-wikipedia-org-4107	184	1	[	[	-LRB-
en-wikipedia-org-4107	184	2	37	37	CD
en-wikipedia-org-4107	184	3	]	]	-RRB-
en-wikipedia-org-4107	184	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	184	5	can	can	MD
en-wikipedia-org-4107	184	6	enter	enter	VB
en-wikipedia-org-4107	184	7	the	the	DT
en-wikipedia-org-4107	184	8	presynaptic	presynaptic	JJ
en-wikipedia-org-4107	184	9	neuron	neuron	NN
en-wikipedia-org-4107	184	10	either	either	CC
en-wikipedia-org-4107	184	11	through	through	IN
en-wikipedia-org-4107	184	12	DAT	DAT	NNP
en-wikipedia-org-4107	184	13	or	or	CC
en-wikipedia-org-4107	184	14	by	by	IN
en-wikipedia-org-4107	184	15	diffusing	diffuse	VBG
en-wikipedia-org-4107	184	16	across	across	IN
en-wikipedia-org-4107	184	17	the	the	DT
en-wikipedia-org-4107	184	18	neuronal	neuronal	JJ
en-wikipedia-org-4107	184	19	membrane	membrane	NN
en-wikipedia-org-4107	184	20	directly	directly	RB
en-wikipedia-org-4107	184	21	.	.	.
en-wikipedia-org-4107	185	1	[	[	-LRB-
en-wikipedia-org-4107	185	2	37	37	CD
en-wikipedia-org-4107	185	3	]	]	-RRB-
en-wikipedia-org-4107	185	4	As	as	IN
en-wikipedia-org-4107	185	5	a	a	DT
en-wikipedia-org-4107	185	6	consequence	consequence	NN
en-wikipedia-org-4107	185	7	of	of	IN
en-wikipedia-org-4107	185	8	DAT	DAT	NNP
en-wikipedia-org-4107	185	9	uptake	uptake	NN
en-wikipedia-org-4107	185	10	,	,	,
en-wikipedia-org-4107	185	11	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	185	12	produces	produce	VBZ
en-wikipedia-org-4107	185	13	competitive	competitive	JJ
en-wikipedia-org-4107	185	14	reuptake	reuptake	NN
en-wikipedia-org-4107	185	15	inhibition	inhibition	NN
en-wikipedia-org-4107	185	16	at	at	IN
en-wikipedia-org-4107	185	17	the	the	DT
en-wikipedia-org-4107	185	18	transporter	transporter	NN
en-wikipedia-org-4107	185	19	.	.	.
en-wikipedia-org-4107	186	1	[	[	-LRB-
en-wikipedia-org-4107	186	2	37	37	CD
en-wikipedia-org-4107	186	3	]	]	-RRB-
en-wikipedia-org-4107	186	4	Upon	upon	IN
en-wikipedia-org-4107	186	5	entering	enter	VBG
en-wikipedia-org-4107	186	6	the	the	DT
en-wikipedia-org-4107	186	7	presynaptic	presynaptic	JJ
en-wikipedia-org-4107	186	8	neuron	neuron	NN
en-wikipedia-org-4107	186	9	,	,	,
en-wikipedia-org-4107	186	10	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	186	11	activates	activate	VBZ
en-wikipedia-org-4107	186	12	TAAR1	TAAR1	NNP
en-wikipedia-org-4107	186	13	which	which	WDT
en-wikipedia-org-4107	186	14	,	,	,
en-wikipedia-org-4107	186	15	through	through	IN
en-wikipedia-org-4107	186	16	protein	protein	NN
en-wikipedia-org-4107	186	17	kinase	kinase	VBD
en-wikipedia-org-4107	186	18	A	a	DT
en-wikipedia-org-4107	186	19	(	(	-LRB-
en-wikipedia-org-4107	186	20	PKA	PKA	NNP
en-wikipedia-org-4107	186	21	)	)	-RRB-
en-wikipedia-org-4107	186	22	and	and	CC
en-wikipedia-org-4107	186	23	protein	protein	NN
en-wikipedia-org-4107	186	24	kinase	kinase	NNP
en-wikipedia-org-4107	186	25	C	C	NNP
en-wikipedia-org-4107	186	26	(	(	-LRB-
en-wikipedia-org-4107	186	27	PKC	PKC	NNP
en-wikipedia-org-4107	186	28	)	)	-RRB-
en-wikipedia-org-4107	186	29	signaling	signal	VBG
en-wikipedia-org-4107	186	30	,	,	,
en-wikipedia-org-4107	186	31	causes	cause	VBZ
en-wikipedia-org-4107	186	32	DAT	DAT	NNP
en-wikipedia-org-4107	186	33	phosphorylation	phosphorylation	NN
en-wikipedia-org-4107	186	34	.	.	.
en-wikipedia-org-4107	187	1	[	[	-LRB-
en-wikipedia-org-4107	187	2	37	37	CD
en-wikipedia-org-4107	187	3	]	]	-RRB-
en-wikipedia-org-4107	187	4	Phosphorylation	phosphorylation	NN
en-wikipedia-org-4107	187	5	by	by	IN
en-wikipedia-org-4107	187	6	either	either	DT
en-wikipedia-org-4107	187	7	protein	protein	NN
en-wikipedia-org-4107	187	8	kinase	kinase	NN
en-wikipedia-org-4107	187	9	can	can	MD
en-wikipedia-org-4107	187	10	result	result	VB
en-wikipedia-org-4107	187	11	in	in	IN
en-wikipedia-org-4107	187	12	DAT	DAT	NNP
en-wikipedia-org-4107	187	13	internalization	internalization	NN
en-wikipedia-org-4107	187	14	(	(	-LRB-
en-wikipedia-org-4107	187	15	non	non	JJ
en-wikipedia-org-4107	187	16	-	-	JJ
en-wikipedia-org-4107	187	17	competitive	competitive	JJ
en-wikipedia-org-4107	187	18	reuptake	reuptake	NN
en-wikipedia-org-4107	187	19	inhibition	inhibition	NN
en-wikipedia-org-4107	187	20	)	)	-RRB-
en-wikipedia-org-4107	187	21	,	,	,
en-wikipedia-org-4107	187	22	but	but	CC
en-wikipedia-org-4107	187	23	PKC	PKC	NNP
en-wikipedia-org-4107	187	24	-	-	HYPH
en-wikipedia-org-4107	187	25	mediated	mediate	VBN
en-wikipedia-org-4107	187	26	phosphorylation	phosphorylation	NN
en-wikipedia-org-4107	187	27	alone	alone	RB
en-wikipedia-org-4107	187	28	induces	induce	VBZ
en-wikipedia-org-4107	187	29	the	the	DT
en-wikipedia-org-4107	187	30	reversal	reversal	NN
en-wikipedia-org-4107	187	31	of	of	IN
en-wikipedia-org-4107	187	32	dopamine	dopamine	NN
en-wikipedia-org-4107	187	33	transport	transport	NN
en-wikipedia-org-4107	187	34	through	through	IN
en-wikipedia-org-4107	187	35	DAT	DAT	NNP
en-wikipedia-org-4107	187	36	(	(	-LRB-
en-wikipedia-org-4107	187	37	i.e.	i.e.	FW
en-wikipedia-org-4107	187	38	,	,	,
en-wikipedia-org-4107	187	39	dopamine	dopamine	NN
en-wikipedia-org-4107	187	40	efflux	efflux	NNP
en-wikipedia-org-4107	187	41	)	)	-RRB-
en-wikipedia-org-4107	187	42	.	.	.
en-wikipedia-org-4107	188	1	[	[	-LRB-
en-wikipedia-org-4107	188	2	note	note	NN
en-wikipedia-org-4107	188	3	16][37][178	16][37][178	CD
en-wikipedia-org-4107	188	4	]	]	-RRB-
en-wikipedia-org-4107	188	5	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	188	6	is	be	VBZ
en-wikipedia-org-4107	188	7	also	also	RB
en-wikipedia-org-4107	188	8	known	know	VBN
en-wikipedia-org-4107	188	9	to	to	TO
en-wikipedia-org-4107	188	10	increase	increase	VB
en-wikipedia-org-4107	188	11	intracellular	intracellular	JJ
en-wikipedia-org-4107	188	12	calcium	calcium	NN
en-wikipedia-org-4107	188	13	,	,	,
en-wikipedia-org-4107	188	14	an	an	DT
en-wikipedia-org-4107	188	15	effect	effect	NN
en-wikipedia-org-4107	188	16	which	which	WDT
en-wikipedia-org-4107	188	17	is	be	VBZ
en-wikipedia-org-4107	188	18	associated	associate	VBN
en-wikipedia-org-4107	188	19	with	with	IN
en-wikipedia-org-4107	188	20	DAT	DAT	NNP
en-wikipedia-org-4107	188	21	phosphorylation	phosphorylation	NN
en-wikipedia-org-4107	188	22	through	through	IN
en-wikipedia-org-4107	188	23	an	an	DT
en-wikipedia-org-4107	188	24	unidentified	unidentified	JJ
en-wikipedia-org-4107	188	25	Ca2+/calmodulin	ca2+/calmodulin	JJ
en-wikipedia-org-4107	188	26	-	-	HYPH
en-wikipedia-org-4107	188	27	dependent	dependent	JJ
en-wikipedia-org-4107	188	28	protein	protein	NN
en-wikipedia-org-4107	188	29	kinase	kinase	NN
en-wikipedia-org-4107	188	30	(	(	-LRB-
en-wikipedia-org-4107	188	31	CAMK)-dependent	camk)-dependent	CD
en-wikipedia-org-4107	188	32	pathway	pathway	NN
en-wikipedia-org-4107	188	33	,	,	,
en-wikipedia-org-4107	188	34	in	in	IN
en-wikipedia-org-4107	188	35	turn	turn	NN
en-wikipedia-org-4107	188	36	producing	produce	VBG
en-wikipedia-org-4107	188	37	dopamine	dopamine	NN
en-wikipedia-org-4107	188	38	efflux	efflux	JJ
en-wikipedia-org-4107	188	39	.	.	.
en-wikipedia-org-4107	189	1	[	[	-LRB-
en-wikipedia-org-4107	189	2	157][155][156	157][155][156	CD
en-wikipedia-org-4107	189	3	]	]	-RRB-
en-wikipedia-org-4107	189	4	Through	through	IN
en-wikipedia-org-4107	189	5	direct	direct	JJ
en-wikipedia-org-4107	189	6	activation	activation	NN
en-wikipedia-org-4107	189	7	of	of	IN
en-wikipedia-org-4107	189	8	G	g	NN
en-wikipedia-org-4107	189	9	protein	protein	NN
en-wikipedia-org-4107	189	10	-	-	HYPH
en-wikipedia-org-4107	189	11	coupled	couple	VBN
en-wikipedia-org-4107	189	12	inwardly	inwardly	RB
en-wikipedia-org-4107	189	13	-	-	HYPH
en-wikipedia-org-4107	189	14	rectifying	rectify	VBG
en-wikipedia-org-4107	189	15	potassium	potassium	NN
en-wikipedia-org-4107	189	16	channels	channel	NNS
en-wikipedia-org-4107	189	17	,	,	,
en-wikipedia-org-4107	189	18	TAAR1	taar1	NN
en-wikipedia-org-4107	189	19	reduces	reduce	VBZ
en-wikipedia-org-4107	189	20	the	the	DT
en-wikipedia-org-4107	189	21	firing	firing	NN
en-wikipedia-org-4107	189	22	rate	rate	NN
en-wikipedia-org-4107	189	23	of	of	IN
en-wikipedia-org-4107	189	24	dopamine	dopamine	NN
en-wikipedia-org-4107	189	25	neurons	neuron	NNS
en-wikipedia-org-4107	189	26	,	,	,
en-wikipedia-org-4107	189	27	preventing	prevent	VBG
en-wikipedia-org-4107	189	28	a	a	DT
en-wikipedia-org-4107	189	29	hyper	hyper	JJ
en-wikipedia-org-4107	189	30	-	-	HYPH
en-wikipedia-org-4107	189	31	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	189	32	state	state	NN
en-wikipedia-org-4107	189	33	.	.	.
en-wikipedia-org-4107	190	1	[	[	-LRB-
en-wikipedia-org-4107	190	2	153][154][179	153][154][179	CD
en-wikipedia-org-4107	190	3	]	]	-RRB-
en-wikipedia-org-4107	190	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	190	5	is	be	VBZ
en-wikipedia-org-4107	190	6	also	also	RB
en-wikipedia-org-4107	190	7	a	a	DT
en-wikipedia-org-4107	190	8	substrate	substrate	NN
en-wikipedia-org-4107	190	9	for	for	IN
en-wikipedia-org-4107	190	10	the	the	DT
en-wikipedia-org-4107	190	11	presynaptic	presynaptic	JJ
en-wikipedia-org-4107	190	12	vesicular	vesicular	JJ
en-wikipedia-org-4107	190	13	monoamine	monoamine	NNP
en-wikipedia-org-4107	190	14	transporter	transporter	NNP
en-wikipedia-org-4107	190	15	,	,	,
en-wikipedia-org-4107	190	16	VMAT2	VMAT2	NNS
en-wikipedia-org-4107	190	17	.	.	.
en-wikipedia-org-4107	191	1	[	[	-LRB-
en-wikipedia-org-4107	191	2	151][152	151][152	CD
en-wikipedia-org-4107	191	3	]	]	-RRB-
en-wikipedia-org-4107	191	4	Following	follow	VBG
en-wikipedia-org-4107	191	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	191	6	uptake	uptake	NN
en-wikipedia-org-4107	191	7	at	at	IN
en-wikipedia-org-4107	191	8	VMAT2	VMAT2	NNP
en-wikipedia-org-4107	191	9	,	,	,
en-wikipedia-org-4107	191	10	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	191	11	induces	induce	VBZ
en-wikipedia-org-4107	191	12	the	the	DT
en-wikipedia-org-4107	191	13	collapse	collapse	NN
en-wikipedia-org-4107	191	14	of	of	IN
en-wikipedia-org-4107	191	15	the	the	DT
en-wikipedia-org-4107	191	16	vesicular	vesicular	JJ
en-wikipedia-org-4107	191	17	pH	pH	NNP
en-wikipedia-org-4107	191	18	gradient	gradient	NN
en-wikipedia-org-4107	191	19	,	,	,
en-wikipedia-org-4107	191	20	which	which	WDT
en-wikipedia-org-4107	191	21	results	result	VBZ
en-wikipedia-org-4107	191	22	in	in	IN
en-wikipedia-org-4107	191	23	the	the	DT
en-wikipedia-org-4107	191	24	release	release	NN
en-wikipedia-org-4107	191	25	of	of	IN
en-wikipedia-org-4107	191	26	dopamine	dopamine	NN
en-wikipedia-org-4107	191	27	molecules	molecule	NNS
en-wikipedia-org-4107	191	28	from	from	IN
en-wikipedia-org-4107	191	29	synaptic	synaptic	JJ
en-wikipedia-org-4107	191	30	vesicles	vesicle	NNS
en-wikipedia-org-4107	191	31	into	into	IN
en-wikipedia-org-4107	191	32	the	the	DT
en-wikipedia-org-4107	191	33	cytosol	cytosol	NN
en-wikipedia-org-4107	191	34	via	via	IN
en-wikipedia-org-4107	191	35	dopamine	dopamine	NN
en-wikipedia-org-4107	191	36	efflux	efflux	NNP
en-wikipedia-org-4107	191	37	through	through	IN
en-wikipedia-org-4107	191	38	VMAT2	VMAT2	NNS
en-wikipedia-org-4107	191	39	.	.	.
en-wikipedia-org-4107	192	1	[	[	-LRB-
en-wikipedia-org-4107	192	2	151][152	151][152	CD
en-wikipedia-org-4107	192	3	]	]	-RRB-
en-wikipedia-org-4107	192	4	Subsequently	subsequently	RB
en-wikipedia-org-4107	192	5	,	,	,
en-wikipedia-org-4107	192	6	the	the	DT
en-wikipedia-org-4107	192	7	cytosolic	cytosolic	JJ
en-wikipedia-org-4107	192	8	dopamine	dopamine	NN
en-wikipedia-org-4107	192	9	molecules	molecule	NNS
en-wikipedia-org-4107	192	10	are	be	VBP
en-wikipedia-org-4107	192	11	released	release	VBN
en-wikipedia-org-4107	192	12	from	from	IN
en-wikipedia-org-4107	192	13	the	the	DT
en-wikipedia-org-4107	192	14	presynaptic	presynaptic	JJ
en-wikipedia-org-4107	192	15	neuron	neuron	NN
en-wikipedia-org-4107	192	16	into	into	IN
en-wikipedia-org-4107	192	17	the	the	DT
en-wikipedia-org-4107	192	18	synaptic	synaptic	JJ
en-wikipedia-org-4107	192	19	cleft	cleft	NNS
en-wikipedia-org-4107	192	20	via	via	IN
en-wikipedia-org-4107	192	21	reverse	reverse	JJ
en-wikipedia-org-4107	192	22	transport	transport	NN
en-wikipedia-org-4107	192	23	at	at	IN
en-wikipedia-org-4107	192	24	DAT	DAT	NNP
en-wikipedia-org-4107	192	25	.	.	.
en-wikipedia-org-4107	193	1	[	[	-LRB-
en-wikipedia-org-4107	193	2	37][151][152	37][151][152	NN
en-wikipedia-org-4107	193	3	]	]	-RRB-
en-wikipedia-org-4107	193	4	Norepinephrine	Norepinephrine	NNP
en-wikipedia-org-4107	193	5	Similar	Similar	NNP
en-wikipedia-org-4107	193	6	to	to	IN
en-wikipedia-org-4107	193	7	dopamine	dopamine	VB
en-wikipedia-org-4107	193	8	,	,	,
en-wikipedia-org-4107	193	9	amphetamine	amphetamine	VB
en-wikipedia-org-4107	193	10	dose	dose	NN
en-wikipedia-org-4107	193	11	-	-	HYPH
en-wikipedia-org-4107	193	12	dependently	dependently	RB
en-wikipedia-org-4107	193	13	increases	increase	VBZ
en-wikipedia-org-4107	193	14	the	the	DT
en-wikipedia-org-4107	193	15	level	level	NN
en-wikipedia-org-4107	193	16	of	of	IN
en-wikipedia-org-4107	193	17	synaptic	synaptic	JJ
en-wikipedia-org-4107	193	18	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	193	19	,	,	,
en-wikipedia-org-4107	193	20	the	the	DT
en-wikipedia-org-4107	193	21	direct	direct	JJ
en-wikipedia-org-4107	193	22	precursor	precursor	NN
en-wikipedia-org-4107	193	23	of	of	IN
en-wikipedia-org-4107	193	24	epinephrine	epinephrine	NN
en-wikipedia-org-4107	193	25	.	.	.
en-wikipedia-org-4107	194	1	[	[	-LRB-
en-wikipedia-org-4107	194	2	46][58	46][58	CD
en-wikipedia-org-4107	194	3	]	]	-RRB-
en-wikipedia-org-4107	194	4	Based	base	VBN
en-wikipedia-org-4107	194	5	upon	upon	IN
en-wikipedia-org-4107	194	6	neuronal	neuronal	JJ
en-wikipedia-org-4107	194	7	TAAR1	taar1	NN
en-wikipedia-org-4107	194	8	mRNA	mRNA	NNP
en-wikipedia-org-4107	194	9	expression	expression	NNP
en-wikipedia-org-4107	194	10	,	,	,
en-wikipedia-org-4107	194	11	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	194	12	is	be	VBZ
en-wikipedia-org-4107	194	13	thought	think	VBN
en-wikipedia-org-4107	194	14	to	to	TO
en-wikipedia-org-4107	194	15	affect	affect	VB
en-wikipedia-org-4107	194	16	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	194	17	analogously	analogously	RB
en-wikipedia-org-4107	194	18	to	to	TO
en-wikipedia-org-4107	194	19	dopamine	dopamine	VB
en-wikipedia-org-4107	194	20	.	.	.
en-wikipedia-org-4107	195	1	[	[	-LRB-
en-wikipedia-org-4107	195	2	37][151][178	37][151][178	CD
en-wikipedia-org-4107	195	3	]	]	-RRB-
en-wikipedia-org-4107	195	4	In	in	IN
en-wikipedia-org-4107	195	5	other	other	JJ
en-wikipedia-org-4107	195	6	words	word	NNS
en-wikipedia-org-4107	195	7	,	,	,
en-wikipedia-org-4107	195	8	amphetamine	amphetamine	VB
en-wikipedia-org-4107	195	9	induces	induce	VBZ
en-wikipedia-org-4107	195	10	TAAR1-mediated	TAAR1-mediated	NNP
en-wikipedia-org-4107	195	11	efflux	efflux	JJ
en-wikipedia-org-4107	195	12	and	and	CC
en-wikipedia-org-4107	195	13	non	non	JJ
en-wikipedia-org-4107	195	14	-	-	JJ
en-wikipedia-org-4107	195	15	competitive	competitive	JJ
en-wikipedia-org-4107	195	16	reuptake	reuptake	NN
en-wikipedia-org-4107	195	17	inhibition	inhibition	NN
en-wikipedia-org-4107	195	18	at	at	IN
en-wikipedia-org-4107	195	19	phosphorylated	phosphorylate	VBN
en-wikipedia-org-4107	195	20	NET	NET	NNP
en-wikipedia-org-4107	195	21	,	,	,
en-wikipedia-org-4107	195	22	competitive	competitive	JJ
en-wikipedia-org-4107	195	23	NET	NET	NNP
en-wikipedia-org-4107	195	24	reuptake	reuptake	NN
en-wikipedia-org-4107	195	25	inhibition	inhibition	NN
en-wikipedia-org-4107	195	26	,	,	,
en-wikipedia-org-4107	195	27	and	and	CC
en-wikipedia-org-4107	195	28	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	195	29	release	release	NN
en-wikipedia-org-4107	195	30	from	from	IN
en-wikipedia-org-4107	195	31	VMAT2	VMAT2	NNS
en-wikipedia-org-4107	195	32	.	.	.
en-wikipedia-org-4107	196	1	[	[	-LRB-
en-wikipedia-org-4107	196	2	37][151	37][151	LS
en-wikipedia-org-4107	196	3	]	]	-RRB-
en-wikipedia-org-4107	196	4	Serotonin	Serotonin	NNP
en-wikipedia-org-4107	196	5	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	196	6	exerts	exert	NNS
en-wikipedia-org-4107	196	7	analogous	analogous	JJ
en-wikipedia-org-4107	196	8	,	,	,
en-wikipedia-org-4107	196	9	yet	yet	RB
en-wikipedia-org-4107	196	10	less	less	RBR
en-wikipedia-org-4107	196	11	pronounced	pronounced	JJ
en-wikipedia-org-4107	196	12	,	,	,
en-wikipedia-org-4107	196	13	effects	effect	NNS
en-wikipedia-org-4107	196	14	on	on	IN
en-wikipedia-org-4107	196	15	serotonin	serotonin	NN
en-wikipedia-org-4107	196	16	as	as	IN
en-wikipedia-org-4107	196	17	on	on	IN
en-wikipedia-org-4107	196	18	dopamine	dopamine	NN
en-wikipedia-org-4107	196	19	and	and	CC
en-wikipedia-org-4107	196	20	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	196	21	.	.	.
en-wikipedia-org-4107	197	1	[	[	-LRB-
en-wikipedia-org-4107	197	2	37][58	37][58	CD
en-wikipedia-org-4107	197	3	]	]	-RRB-
en-wikipedia-org-4107	197	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	197	5	affects	affect	VBZ
en-wikipedia-org-4107	197	6	serotonin	serotonin	NN
en-wikipedia-org-4107	197	7	via	via	IN
en-wikipedia-org-4107	197	8	VMAT2	vmat2	NN
en-wikipedia-org-4107	197	9	and	and	CC
en-wikipedia-org-4107	197	10	,	,	,
en-wikipedia-org-4107	197	11	like	like	IN
en-wikipedia-org-4107	197	12	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	197	13	,	,	,
en-wikipedia-org-4107	197	14	is	be	VBZ
en-wikipedia-org-4107	197	15	thought	think	VBN
en-wikipedia-org-4107	197	16	to	to	TO
en-wikipedia-org-4107	197	17	phosphorylate	phosphorylate	VB
en-wikipedia-org-4107	197	18	SERT	SERT	NNP
en-wikipedia-org-4107	197	19	via	via	IN
en-wikipedia-org-4107	197	20	TAAR1	taar1	NN
en-wikipedia-org-4107	197	21	.	.	.
en-wikipedia-org-4107	198	1	[	[	-LRB-
en-wikipedia-org-4107	198	2	37][151	37][151	NFP
en-wikipedia-org-4107	198	3	]	]	-RRB-
en-wikipedia-org-4107	198	4	Like	like	UH
en-wikipedia-org-4107	198	5	dopamine	dopamine	NN
en-wikipedia-org-4107	198	6	,	,	,
en-wikipedia-org-4107	198	7	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	198	8	has	have	VBZ
en-wikipedia-org-4107	198	9	low	low	JJ
en-wikipedia-org-4107	198	10	,	,	,
en-wikipedia-org-4107	198	11	micromolar	micromolar	JJ
en-wikipedia-org-4107	198	12	affinity	affinity	NN
en-wikipedia-org-4107	198	13	at	at	IN
en-wikipedia-org-4107	198	14	the	the	DT
en-wikipedia-org-4107	198	15	human	human	JJ
en-wikipedia-org-4107	198	16	5-HT1A	5-ht1a	JJ
en-wikipedia-org-4107	198	17	receptor	receptor	NN
en-wikipedia-org-4107	198	18	.	.	.
en-wikipedia-org-4107	199	1	[	[	-LRB-
en-wikipedia-org-4107	199	2	169][170	169][170	LS
en-wikipedia-org-4107	199	3	]	]	-RRB-
en-wikipedia-org-4107	199	4	Other	other	JJ
en-wikipedia-org-4107	199	5	neurotransmitters	neurotransmitter	NNS
en-wikipedia-org-4107	199	6	,	,	,
en-wikipedia-org-4107	199	7	peptides	peptide	NNS
en-wikipedia-org-4107	199	8	,	,	,
en-wikipedia-org-4107	199	9	hormones	hormone	NNS
en-wikipedia-org-4107	199	10	,	,	,
en-wikipedia-org-4107	199	11	and	and	CC
en-wikipedia-org-4107	199	12	enzymes	enzyme	VBZ
en-wikipedia-org-4107	199	13	Human	Human	NNP
en-wikipedia-org-4107	199	14	carbonic	carbonic	JJ
en-wikipedia-org-4107	199	15	anhydrase	anhydrase	NN
en-wikipedia-org-4107	199	16	activation	activation	NN
en-wikipedia-org-4107	199	17	potency	potency	NN
en-wikipedia-org-4107	199	18	Enzyme	Enzyme	NNP
en-wikipedia-org-4107	199	19	KA	KA	NNP
en-wikipedia-org-4107	199	20	(	(	-LRB-
en-wikipedia-org-4107	199	21	nM	nM	NNP
en-wikipedia-org-4107	199	22	)	)	-RRB-
en-wikipedia-org-4107	199	23	Sources	Sources	NNP
en-wikipedia-org-4107	199	24	hCA4	hCA4	NNP
en-wikipedia-org-4107	199	25	94	94	CD
en-wikipedia-org-4107	199	26	[	[	-LRB-
en-wikipedia-org-4107	199	27	176	176	CD
en-wikipedia-org-4107	199	28	]	]	-RRB-
en-wikipedia-org-4107	199	29	hCA5A	hCA5A	-LRB-
en-wikipedia-org-4107	199	30	810	810	CD
en-wikipedia-org-4107	199	31	[	[	-LRB-
en-wikipedia-org-4107	199	32	176][180	176][180	CD
en-wikipedia-org-4107	199	33	]	]	-RRB-
en-wikipedia-org-4107	199	34	hCA5B	hca5b	CD
en-wikipedia-org-4107	199	35	2560	2560	CD
en-wikipedia-org-4107	199	36	[	[	-LRB-
en-wikipedia-org-4107	199	37	176	176	CD
en-wikipedia-org-4107	199	38	]	]	-RRB-
en-wikipedia-org-4107	199	39	hCA7	hca7	NN
en-wikipedia-org-4107	199	40	910	910	CD
en-wikipedia-org-4107	199	41	[	[	-LRB-
en-wikipedia-org-4107	199	42	176][180	176][180	CD
en-wikipedia-org-4107	199	43	]	]	-RRB-
en-wikipedia-org-4107	199	44	hCA12	hCA12	NNS
en-wikipedia-org-4107	199	45	640	640	CD
en-wikipedia-org-4107	199	46	[	[	-LRB-
en-wikipedia-org-4107	199	47	176	176	CD
en-wikipedia-org-4107	199	48	]	]	-RRB-
en-wikipedia-org-4107	199	49	hCA13	hCA13	NNP
en-wikipedia-org-4107	199	50	24100	24100	CD
en-wikipedia-org-4107	199	51	[	[	-LRB-
en-wikipedia-org-4107	199	52	176	176	CD
en-wikipedia-org-4107	199	53	]	]	-RRB-
en-wikipedia-org-4107	199	54	hCA14	hca14	NN
en-wikipedia-org-4107	199	55	9150	9150	CD
en-wikipedia-org-4107	199	56	[	[	-LRB-
en-wikipedia-org-4107	199	57	176	176	CD
en-wikipedia-org-4107	199	58	]	]	-RRB-
en-wikipedia-org-4107	199	59	Acute	Acute	NNP
en-wikipedia-org-4107	199	60	amphetamine	amphetamine	NN
en-wikipedia-org-4107	199	61	administration	administration	NN
en-wikipedia-org-4107	199	62	in	in	IN
en-wikipedia-org-4107	199	63	humans	human	NNS
en-wikipedia-org-4107	199	64	increases	increase	VBZ
en-wikipedia-org-4107	199	65	endogenous	endogenous	JJ
en-wikipedia-org-4107	199	66	opioid	opioid	NN
en-wikipedia-org-4107	199	67	release	release	NN
en-wikipedia-org-4107	199	68	in	in	IN
en-wikipedia-org-4107	199	69	several	several	JJ
en-wikipedia-org-4107	199	70	brain	brain	NN
en-wikipedia-org-4107	199	71	structures	structure	NNS
en-wikipedia-org-4107	199	72	in	in	IN
en-wikipedia-org-4107	199	73	the	the	DT
en-wikipedia-org-4107	199	74	reward	reward	NN
en-wikipedia-org-4107	199	75	system	system	NN
en-wikipedia-org-4107	199	76	.	.	.
en-wikipedia-org-4107	200	1	[	[	-LRB-
en-wikipedia-org-4107	200	2	171][172][173	171][172][173	CD
en-wikipedia-org-4107	200	3	]	]	-RRB-
en-wikipedia-org-4107	200	4	Extracellular	Extracellular	NNP
en-wikipedia-org-4107	200	5	levels	level	NNS
en-wikipedia-org-4107	200	6	of	of	IN
en-wikipedia-org-4107	200	7	glutamate	glutamate	NN
en-wikipedia-org-4107	200	8	,	,	,
en-wikipedia-org-4107	200	9	the	the	DT
en-wikipedia-org-4107	200	10	primary	primary	JJ
en-wikipedia-org-4107	200	11	excitatory	excitatory	NN
en-wikipedia-org-4107	200	12	neurotransmitter	neurotransmitter	NN
en-wikipedia-org-4107	200	13	in	in	IN
en-wikipedia-org-4107	200	14	the	the	DT
en-wikipedia-org-4107	200	15	brain	brain	NN
en-wikipedia-org-4107	200	16	,	,	,
en-wikipedia-org-4107	200	17	have	have	VBP
en-wikipedia-org-4107	200	18	been	be	VBN
en-wikipedia-org-4107	200	19	shown	show	VBN
en-wikipedia-org-4107	200	20	to	to	TO
en-wikipedia-org-4107	200	21	increase	increase	VB
en-wikipedia-org-4107	200	22	in	in	IN
en-wikipedia-org-4107	200	23	the	the	DT
en-wikipedia-org-4107	200	24	striatum	striatum	NN
en-wikipedia-org-4107	200	25	following	follow	VBG
en-wikipedia-org-4107	200	26	exposure	exposure	NN
en-wikipedia-org-4107	200	27	to	to	TO
en-wikipedia-org-4107	200	28	amphetamine	amphetamine	VB
en-wikipedia-org-4107	200	29	.	.	.
en-wikipedia-org-4107	201	1	[	[	-LRB-
en-wikipedia-org-4107	201	2	155	155	CD
en-wikipedia-org-4107	201	3	]	]	-RRB-
en-wikipedia-org-4107	201	4	This	this	DT
en-wikipedia-org-4107	201	5	increase	increase	NN
en-wikipedia-org-4107	201	6	in	in	IN
en-wikipedia-org-4107	201	7	extracellular	extracellular	NNP
en-wikipedia-org-4107	201	8	glutamate	glutamate	NN
en-wikipedia-org-4107	201	9	presumably	presumably	RB
en-wikipedia-org-4107	201	10	occurs	occur	VBZ
en-wikipedia-org-4107	201	11	via	via	IN
en-wikipedia-org-4107	201	12	the	the	DT
en-wikipedia-org-4107	201	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	201	14	-	-	HYPH
en-wikipedia-org-4107	201	15	induced	induce	VBN
en-wikipedia-org-4107	201	16	internalization	internalization	NN
en-wikipedia-org-4107	201	17	of	of	IN
en-wikipedia-org-4107	201	18	EAAT3	EAAT3	NNP
en-wikipedia-org-4107	201	19	,	,	,
en-wikipedia-org-4107	201	20	a	a	DT
en-wikipedia-org-4107	201	21	glutamate	glutamate	NN
en-wikipedia-org-4107	201	22	reuptake	reuptake	NN
en-wikipedia-org-4107	201	23	transporter	transporter	NN
en-wikipedia-org-4107	201	24	,	,	,
en-wikipedia-org-4107	201	25	in	in	IN
en-wikipedia-org-4107	201	26	dopamine	dopamine	NN
en-wikipedia-org-4107	201	27	neurons	neuron	NNS
en-wikipedia-org-4107	201	28	.	.	.
en-wikipedia-org-4107	202	1	[	[	-LRB-
en-wikipedia-org-4107	202	2	155][160	155][160	LS
en-wikipedia-org-4107	202	3	]	]	-RRB-
en-wikipedia-org-4107	202	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	202	5	also	also	RB
en-wikipedia-org-4107	202	6	induces	induce	VBZ
en-wikipedia-org-4107	202	7	the	the	DT
en-wikipedia-org-4107	202	8	selective	selective	JJ
en-wikipedia-org-4107	202	9	release	release	NN
en-wikipedia-org-4107	202	10	of	of	IN
en-wikipedia-org-4107	202	11	histamine	histamine	NN
en-wikipedia-org-4107	202	12	from	from	IN
en-wikipedia-org-4107	202	13	mast	mast	JJ
en-wikipedia-org-4107	202	14	cells	cell	NNS
en-wikipedia-org-4107	202	15	and	and	CC
en-wikipedia-org-4107	202	16	efflux	efflux	JJ
en-wikipedia-org-4107	202	17	from	from	IN
en-wikipedia-org-4107	202	18	histaminergic	histaminergic	JJ
en-wikipedia-org-4107	202	19	neurons	neuron	NNS
en-wikipedia-org-4107	202	20	through	through	IN
en-wikipedia-org-4107	202	21	VMAT2	VMAT2	NNS
en-wikipedia-org-4107	202	22	.	.	.
en-wikipedia-org-4107	203	1	[	[	-LRB-
en-wikipedia-org-4107	203	2	151	151	CD
en-wikipedia-org-4107	203	3	]	]	-RRB-
en-wikipedia-org-4107	203	4	Acute	Acute	NNP
en-wikipedia-org-4107	203	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	203	6	administration	administration	NN
en-wikipedia-org-4107	203	7	can	can	MD
en-wikipedia-org-4107	203	8	also	also	RB
en-wikipedia-org-4107	203	9	increase	increase	VB
en-wikipedia-org-4107	203	10	adrenocorticotropic	adrenocorticotropic	JJ
en-wikipedia-org-4107	203	11	hormone	hormone	NN
en-wikipedia-org-4107	203	12	and	and	CC
en-wikipedia-org-4107	203	13	corticosteroid	corticosteroid	JJ
en-wikipedia-org-4107	203	14	levels	level	NNS
en-wikipedia-org-4107	203	15	in	in	IN
en-wikipedia-org-4107	203	16	blood	blood	NN
en-wikipedia-org-4107	203	17	plasma	plasma	NN
en-wikipedia-org-4107	203	18	by	by	IN
en-wikipedia-org-4107	203	19	stimulating	stimulate	VBG
en-wikipedia-org-4107	203	20	the	the	DT
en-wikipedia-org-4107	203	21	hypothalamic	hypothalamic	JJ
en-wikipedia-org-4107	203	22	–	–	:
en-wikipedia-org-4107	203	23	pituitary	pituitary	JJ
en-wikipedia-org-4107	203	24	–	–	:
en-wikipedia-org-4107	203	25	adrenal	adrenal	JJ
en-wikipedia-org-4107	203	26	axis	axis	NNP
en-wikipedia-org-4107	203	27	.	.	.
en-wikipedia-org-4107	204	1	[	[	-LRB-
en-wikipedia-org-4107	204	2	35][174][175	35][174][175	NNP
en-wikipedia-org-4107	204	3	]	]	-RRB-
en-wikipedia-org-4107	204	4	In	in	IN
en-wikipedia-org-4107	204	5	December	December	NNP
en-wikipedia-org-4107	204	6	2017	2017	CD
en-wikipedia-org-4107	204	7	,	,	,
en-wikipedia-org-4107	204	8	the	the	DT
en-wikipedia-org-4107	204	9	first	first	JJ
en-wikipedia-org-4107	204	10	study	study	NN
en-wikipedia-org-4107	204	11	assessing	assess	VBG
en-wikipedia-org-4107	204	12	the	the	DT
en-wikipedia-org-4107	204	13	interaction	interaction	NN
en-wikipedia-org-4107	204	14	between	between	IN
en-wikipedia-org-4107	204	15	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	204	16	and	and	CC
en-wikipedia-org-4107	204	17	human	human	JJ
en-wikipedia-org-4107	204	18	carbonic	carbonic	JJ
en-wikipedia-org-4107	204	19	anhydrase	anhydrase	NN
en-wikipedia-org-4107	204	20	enzymes	enzyme	NNS
en-wikipedia-org-4107	204	21	was	be	VBD
en-wikipedia-org-4107	204	22	published;[176	published;[176	NNS
en-wikipedia-org-4107	204	23	]	]	-RRB-
en-wikipedia-org-4107	204	24	of	of	IN
en-wikipedia-org-4107	204	25	the	the	DT
en-wikipedia-org-4107	204	26	eleven	eleven	CD
en-wikipedia-org-4107	204	27	carbonic	carbonic	JJ
en-wikipedia-org-4107	204	28	anhydrase	anhydrase	NN
en-wikipedia-org-4107	204	29	enzymes	enzyme	NNS
en-wikipedia-org-4107	204	30	it	-PRON-	PRP
en-wikipedia-org-4107	204	31	examined	examine	VBD
en-wikipedia-org-4107	204	32	,	,	,
en-wikipedia-org-4107	204	33	it	-PRON-	PRP
en-wikipedia-org-4107	204	34	found	find	VBD
en-wikipedia-org-4107	204	35	that	that	IN
en-wikipedia-org-4107	204	36	amphetamine	amphetamine	NN
en-wikipedia-org-4107	204	37	potently	potently	RB
en-wikipedia-org-4107	204	38	activates	activate	VBZ
en-wikipedia-org-4107	204	39	seven	seven	CD
en-wikipedia-org-4107	204	40	,	,	,
en-wikipedia-org-4107	204	41	four	four	CD
en-wikipedia-org-4107	204	42	of	of	IN
en-wikipedia-org-4107	204	43	which	which	WDT
en-wikipedia-org-4107	204	44	are	be	VBP
en-wikipedia-org-4107	204	45	highly	highly	RB
en-wikipedia-org-4107	204	46	expressed	express	VBN
en-wikipedia-org-4107	204	47	in	in	IN
en-wikipedia-org-4107	204	48	the	the	DT
en-wikipedia-org-4107	204	49	human	human	JJ
en-wikipedia-org-4107	204	50	brain	brain	NN
en-wikipedia-org-4107	204	51	,	,	,
en-wikipedia-org-4107	204	52	with	with	IN
en-wikipedia-org-4107	204	53	low	low	JJ
en-wikipedia-org-4107	204	54	nanomolar	nanomolar	NN
en-wikipedia-org-4107	204	55	through	through	IN
en-wikipedia-org-4107	204	56	low	low	JJ
en-wikipedia-org-4107	204	57	micromolar	micromolar	JJ
en-wikipedia-org-4107	204	58	activating	activate	VBG
en-wikipedia-org-4107	204	59	effects	effect	NNS
en-wikipedia-org-4107	204	60	.	.	.
en-wikipedia-org-4107	205	1	[	[	-LRB-
en-wikipedia-org-4107	205	2	176	176	CD
en-wikipedia-org-4107	205	3	]	]	-RRB-
en-wikipedia-org-4107	205	4	Based	base	VBN
en-wikipedia-org-4107	205	5	upon	upon	IN
en-wikipedia-org-4107	205	6	preclinical	preclinical	JJ
en-wikipedia-org-4107	205	7	research	research	NN
en-wikipedia-org-4107	205	8	,	,	,
en-wikipedia-org-4107	205	9	cerebral	cerebral	NNP
en-wikipedia-org-4107	205	10	carbonic	carbonic	NNP
en-wikipedia-org-4107	205	11	anhydrase	anhydrase	NNP
en-wikipedia-org-4107	205	12	activation	activation	NNP
en-wikipedia-org-4107	205	13	has	have	VBZ
en-wikipedia-org-4107	205	14	cognition	cognition	NN
en-wikipedia-org-4107	205	15	-	-	HYPH
en-wikipedia-org-4107	205	16	enhancing	enhance	VBG
en-wikipedia-org-4107	205	17	effects;[181	effects;[181	ADD
en-wikipedia-org-4107	205	18	]	]	-RRB-
en-wikipedia-org-4107	205	19	but	but	CC
en-wikipedia-org-4107	205	20	,	,	,
en-wikipedia-org-4107	205	21	based	base	VBN
en-wikipedia-org-4107	205	22	upon	upon	IN
en-wikipedia-org-4107	205	23	the	the	DT
en-wikipedia-org-4107	205	24	clinical	clinical	JJ
en-wikipedia-org-4107	205	25	use	use	NN
en-wikipedia-org-4107	205	26	of	of	IN
en-wikipedia-org-4107	205	27	carbonic	carbonic	JJ
en-wikipedia-org-4107	205	28	anhydrase	anhydrase	NN
en-wikipedia-org-4107	205	29	inhibitors	inhibitor	NNS
en-wikipedia-org-4107	205	30	,	,	,
en-wikipedia-org-4107	205	31	carbonic	carbonic	NNP
en-wikipedia-org-4107	205	32	anhydrase	anhydrase	NNP
en-wikipedia-org-4107	205	33	activation	activation	NN
en-wikipedia-org-4107	205	34	in	in	IN
en-wikipedia-org-4107	205	35	other	other	JJ
en-wikipedia-org-4107	205	36	tissues	tissue	NNS
en-wikipedia-org-4107	205	37	may	may	MD
en-wikipedia-org-4107	205	38	be	be	VB
en-wikipedia-org-4107	205	39	associated	associate	VBN
en-wikipedia-org-4107	205	40	with	with	IN
en-wikipedia-org-4107	205	41	adverse	adverse	JJ
en-wikipedia-org-4107	205	42	effects	effect	NNS
en-wikipedia-org-4107	205	43	,	,	,
en-wikipedia-org-4107	205	44	such	such	JJ
en-wikipedia-org-4107	205	45	as	as	IN
en-wikipedia-org-4107	205	46	ocular	ocular	NNP
en-wikipedia-org-4107	205	47	activation	activation	NNP
en-wikipedia-org-4107	205	48	exacerbating	exacerbate	VBG
en-wikipedia-org-4107	205	49	glaucoma	glaucoma	NN
en-wikipedia-org-4107	205	50	.	.	.
en-wikipedia-org-4107	206	1	[	[	-LRB-
en-wikipedia-org-4107	206	2	181	181	CD
en-wikipedia-org-4107	206	3	]	]	-RRB-
en-wikipedia-org-4107	206	4	Pharmacokinetics	pharmacokinetic	NNS
en-wikipedia-org-4107	206	5	The	the	DT
en-wikipedia-org-4107	206	6	oral	oral	JJ
en-wikipedia-org-4107	206	7	bioavailability	bioavailability	NN
en-wikipedia-org-4107	206	8	of	of	IN
en-wikipedia-org-4107	206	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	206	10	varies	vary	VBZ
en-wikipedia-org-4107	206	11	with	with	IN
en-wikipedia-org-4107	206	12	gastrointestinal	gastrointestinal	JJ
en-wikipedia-org-4107	206	13	pH;[28	ph;[28	NN
en-wikipedia-org-4107	206	14	]	]	-RRB-
en-wikipedia-org-4107	206	15	it	-PRON-	PRP
en-wikipedia-org-4107	206	16	is	be	VBZ
en-wikipedia-org-4107	206	17	well	well	RB
en-wikipedia-org-4107	206	18	absorbed	absorb	VBN
en-wikipedia-org-4107	206	19	from	from	IN
en-wikipedia-org-4107	206	20	the	the	DT
en-wikipedia-org-4107	206	21	gut	gut	NN
en-wikipedia-org-4107	206	22	,	,	,
en-wikipedia-org-4107	206	23	and	and	CC
en-wikipedia-org-4107	206	24	bioavailability	bioavailability	NN
en-wikipedia-org-4107	206	25	is	be	VBZ
en-wikipedia-org-4107	206	26	typically	typically	RB
en-wikipedia-org-4107	206	27	over	over	IN
en-wikipedia-org-4107	206	28	 	  	_SP
en-wikipedia-org-4107	206	29	75	75	CD
en-wikipedia-org-4107	206	30	%	%	NN
en-wikipedia-org-4107	206	31	for	for	IN
en-wikipedia-org-4107	206	32	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	206	33	.	.	.
en-wikipedia-org-4107	207	1	[	[	-LRB-
en-wikipedia-org-4107	207	2	4	4	LS
en-wikipedia-org-4107	207	3	]	]	-RRB-
en-wikipedia-org-4107	207	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	207	5	is	be	VBZ
en-wikipedia-org-4107	207	6	a	a	DT
en-wikipedia-org-4107	207	7	weak	weak	JJ
en-wikipedia-org-4107	207	8	base	base	NN
en-wikipedia-org-4107	207	9	with	with	IN
en-wikipedia-org-4107	207	10	a	a	DT
en-wikipedia-org-4107	207	11	pKa	pka	NN
en-wikipedia-org-4107	207	12	of	of	IN
en-wikipedia-org-4107	207	13	9.9;[6	9.9;[6	NN
en-wikipedia-org-4107	207	14	]	]	-RRB-
en-wikipedia-org-4107	207	15	consequently	consequently	RB
en-wikipedia-org-4107	207	16	,	,	,
en-wikipedia-org-4107	207	17	when	when	WRB
en-wikipedia-org-4107	207	18	the	the	DT
en-wikipedia-org-4107	207	19	pH	pH	NNP
en-wikipedia-org-4107	207	20	is	be	VBZ
en-wikipedia-org-4107	207	21	basic	basic	JJ
en-wikipedia-org-4107	207	22	,	,	,
en-wikipedia-org-4107	207	23	more	more	JJR
en-wikipedia-org-4107	207	24	of	of	IN
en-wikipedia-org-4107	207	25	the	the	DT
en-wikipedia-org-4107	207	26	drug	drug	NN
en-wikipedia-org-4107	207	27	is	be	VBZ
en-wikipedia-org-4107	207	28	in	in	IN
en-wikipedia-org-4107	207	29	its	-PRON-	PRP$
en-wikipedia-org-4107	207	30	lipid	lipid	NN
en-wikipedia-org-4107	207	31	soluble	soluble	JJ
en-wikipedia-org-4107	207	32	free	free	JJ
en-wikipedia-org-4107	207	33	base	base	NN
en-wikipedia-org-4107	207	34	form	form	NN
en-wikipedia-org-4107	207	35	,	,	,
en-wikipedia-org-4107	207	36	and	and	CC
en-wikipedia-org-4107	207	37	more	more	JJR
en-wikipedia-org-4107	207	38	is	be	VBZ
en-wikipedia-org-4107	207	39	absorbed	absorb	VBN
en-wikipedia-org-4107	207	40	through	through	IN
en-wikipedia-org-4107	207	41	the	the	DT
en-wikipedia-org-4107	207	42	lipid	lipid	NN
en-wikipedia-org-4107	207	43	-	-	HYPH
en-wikipedia-org-4107	207	44	rich	rich	JJ
en-wikipedia-org-4107	207	45	cell	cell	NN
en-wikipedia-org-4107	207	46	membranes	membrane	NNS
en-wikipedia-org-4107	207	47	of	of	IN
en-wikipedia-org-4107	207	48	the	the	DT
en-wikipedia-org-4107	207	49	gut	gut	NNP
en-wikipedia-org-4107	207	50	epithelium	epithelium	NN
en-wikipedia-org-4107	207	51	.	.	.
en-wikipedia-org-4107	208	1	[	[	-LRB-
en-wikipedia-org-4107	208	2	6][28	6][28	CD
en-wikipedia-org-4107	208	3	]	]	-RRB-
en-wikipedia-org-4107	208	4	Conversely	conversely	RB
en-wikipedia-org-4107	208	5	,	,	,
en-wikipedia-org-4107	208	6	an	an	DT
en-wikipedia-org-4107	208	7	acidic	acidic	JJ
en-wikipedia-org-4107	208	8	pH	pH	NNP
en-wikipedia-org-4107	208	9	means	mean	VBZ
en-wikipedia-org-4107	208	10	the	the	DT
en-wikipedia-org-4107	208	11	drug	drug	NN
en-wikipedia-org-4107	208	12	is	be	VBZ
en-wikipedia-org-4107	208	13	predominantly	predominantly	RB
en-wikipedia-org-4107	208	14	in	in	IN
en-wikipedia-org-4107	208	15	a	a	DT
en-wikipedia-org-4107	208	16	water	water	NN
en-wikipedia-org-4107	208	17	-	-	HYPH
en-wikipedia-org-4107	208	18	soluble	soluble	JJ
en-wikipedia-org-4107	208	19	cationic	cationic	NN
en-wikipedia-org-4107	208	20	(	(	-LRB-
en-wikipedia-org-4107	208	21	salt	salt	NN
en-wikipedia-org-4107	208	22	)	)	-RRB-
en-wikipedia-org-4107	208	23	form	form	NN
en-wikipedia-org-4107	208	24	,	,	,
en-wikipedia-org-4107	208	25	and	and	CC
en-wikipedia-org-4107	208	26	less	less	RBR
en-wikipedia-org-4107	208	27	is	be	VBZ
en-wikipedia-org-4107	208	28	absorbed	absorb	VBN
en-wikipedia-org-4107	208	29	.	.	.
en-wikipedia-org-4107	209	1	[	[	-LRB-
en-wikipedia-org-4107	209	2	6	6	CD
en-wikipedia-org-4107	209	3	]	]	-RRB-
en-wikipedia-org-4107	209	4	Approximately	approximately	RB
en-wikipedia-org-4107	209	5	20	20	CD
en-wikipedia-org-4107	209	6	%	%	NN
en-wikipedia-org-4107	209	7	of	of	IN
en-wikipedia-org-4107	209	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	209	9	circulating	circulate	VBG
en-wikipedia-org-4107	209	10	in	in	IN
en-wikipedia-org-4107	209	11	the	the	DT
en-wikipedia-org-4107	209	12	bloodstream	bloodstream	NN
en-wikipedia-org-4107	209	13	is	be	VBZ
en-wikipedia-org-4107	209	14	bound	bind	VBN
en-wikipedia-org-4107	209	15	to	to	IN
en-wikipedia-org-4107	209	16	plasma	plasma	NN
en-wikipedia-org-4107	209	17	proteins	protein	NNS
en-wikipedia-org-4107	209	18	.	.	.
en-wikipedia-org-4107	210	1	[	[	-LRB-
en-wikipedia-org-4107	210	2	5	5	CD
en-wikipedia-org-4107	210	3	]	]	-RRB-
en-wikipedia-org-4107	210	4	Following	follow	VBG
en-wikipedia-org-4107	210	5	absorption	absorption	NN
en-wikipedia-org-4107	210	6	,	,	,
en-wikipedia-org-4107	210	7	amphetamine	amphetamine	VB
en-wikipedia-org-4107	210	8	readily	readily	RB
en-wikipedia-org-4107	210	9	distributes	distribute	VBZ
en-wikipedia-org-4107	210	10	into	into	IN
en-wikipedia-org-4107	210	11	most	most	JJS
en-wikipedia-org-4107	210	12	tissues	tissue	NNS
en-wikipedia-org-4107	210	13	in	in	IN
en-wikipedia-org-4107	210	14	the	the	DT
en-wikipedia-org-4107	210	15	body	body	NN
en-wikipedia-org-4107	210	16	,	,	,
en-wikipedia-org-4107	210	17	with	with	IN
en-wikipedia-org-4107	210	18	high	high	JJ
en-wikipedia-org-4107	210	19	concentrations	concentration	NNS
en-wikipedia-org-4107	210	20	occurring	occur	VBG
en-wikipedia-org-4107	210	21	in	in	IN
en-wikipedia-org-4107	210	22	cerebrospinal	cerebrospinal	JJ
en-wikipedia-org-4107	210	23	fluid	fluid	NN
en-wikipedia-org-4107	210	24	and	and	CC
en-wikipedia-org-4107	210	25	brain	brain	NN
en-wikipedia-org-4107	210	26	tissue	tissue	NN
en-wikipedia-org-4107	210	27	.	.	.
en-wikipedia-org-4107	211	1	[	[	-LRB-
en-wikipedia-org-4107	211	2	12	12	CD
en-wikipedia-org-4107	211	3	]	]	-RRB-
en-wikipedia-org-4107	211	4	The	the	DT
en-wikipedia-org-4107	211	5	half	half	NN
en-wikipedia-org-4107	211	6	-	-	HYPH
en-wikipedia-org-4107	211	7	lives	life	NNS
en-wikipedia-org-4107	211	8	of	of	IN
en-wikipedia-org-4107	211	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	211	10	enantiomers	enantiomer	NNS
en-wikipedia-org-4107	211	11	differ	differ	VBP
en-wikipedia-org-4107	211	12	and	and	CC
en-wikipedia-org-4107	211	13	vary	vary	VBP
en-wikipedia-org-4107	211	14	with	with	IN
en-wikipedia-org-4107	211	15	urine	urine	NN
en-wikipedia-org-4107	211	16	pH.	pH.	NNP
en-wikipedia-org-4107	212	1	[	[	-LRB-
en-wikipedia-org-4107	212	2	6	6	CD
en-wikipedia-org-4107	212	3	]	]	-RRB-
en-wikipedia-org-4107	212	4	At	at	IN
en-wikipedia-org-4107	212	5	normal	normal	JJ
en-wikipedia-org-4107	212	6	urine	urine	NN
en-wikipedia-org-4107	212	7	pH	pH	NNP
en-wikipedia-org-4107	212	8	,	,	,
en-wikipedia-org-4107	212	9	the	the	DT
en-wikipedia-org-4107	212	10	half	half	NN
en-wikipedia-org-4107	212	11	-	-	HYPH
en-wikipedia-org-4107	212	12	lives	life	NNS
en-wikipedia-org-4107	212	13	of	of	IN
en-wikipedia-org-4107	212	14	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	212	15	and	and	CC
en-wikipedia-org-4107	212	16	levoamphetamine	levoamphetamine	NN
en-wikipedia-org-4107	212	17	are	be	VBP
en-wikipedia-org-4107	212	18	9–11	9–11	CD
en-wikipedia-org-4107	212	19	 	  	_SP
en-wikipedia-org-4107	212	20	hours	hour	NNS
en-wikipedia-org-4107	212	21	and	and	CC
en-wikipedia-org-4107	212	22	11–14	11–14	JJ
en-wikipedia-org-4107	212	23	 	  	_SP
en-wikipedia-org-4107	212	24	hours	hour	NNS
en-wikipedia-org-4107	212	25	,	,	,
en-wikipedia-org-4107	212	26	respectively	respectively	RB
en-wikipedia-org-4107	212	27	.	.	.
en-wikipedia-org-4107	213	1	[	[	-LRB-
en-wikipedia-org-4107	213	2	6	6	CD
en-wikipedia-org-4107	213	3	]	]	-RRB-
en-wikipedia-org-4107	213	4	Highly	highly	RB
en-wikipedia-org-4107	213	5	acidic	acidic	JJ
en-wikipedia-org-4107	213	6	urine	urine	NN
en-wikipedia-org-4107	213	7	will	will	MD
en-wikipedia-org-4107	213	8	reduce	reduce	VB
en-wikipedia-org-4107	213	9	the	the	DT
en-wikipedia-org-4107	213	10	enantiomer	enantiom	JJR
en-wikipedia-org-4107	213	11	half	half	NN
en-wikipedia-org-4107	213	12	-	-	HYPH
en-wikipedia-org-4107	213	13	lives	life	NNS
en-wikipedia-org-4107	213	14	to	to	IN
en-wikipedia-org-4107	213	15	7	7	CD
en-wikipedia-org-4107	213	16	 	  	_SP
en-wikipedia-org-4107	213	17	hours;[12	hours;[12	NNP
en-wikipedia-org-4107	213	18	]	]	-RRB-
en-wikipedia-org-4107	213	19	highly	highly	RB
en-wikipedia-org-4107	213	20	alkaline	alkaline	VBP
en-wikipedia-org-4107	213	21	urine	urine	NN
en-wikipedia-org-4107	213	22	will	will	MD
en-wikipedia-org-4107	213	23	increase	increase	VB
en-wikipedia-org-4107	213	24	the	the	DT
en-wikipedia-org-4107	213	25	half	half	NN
en-wikipedia-org-4107	213	26	-	-	HYPH
en-wikipedia-org-4107	213	27	lives	life	NNS
en-wikipedia-org-4107	213	28	up	up	IN
en-wikipedia-org-4107	213	29	to	to	TO
en-wikipedia-org-4107	213	30	34	34	CD
en-wikipedia-org-4107	213	31	 	  	_SP
en-wikipedia-org-4107	213	32	hours	hour	NNS
en-wikipedia-org-4107	213	33	.	.	.
en-wikipedia-org-4107	214	1	[	[	-LRB-
en-wikipedia-org-4107	214	2	12	12	CD
en-wikipedia-org-4107	214	3	]	]	-RRB-
en-wikipedia-org-4107	214	4	The	the	DT
en-wikipedia-org-4107	214	5	immediate	immediate	JJ
en-wikipedia-org-4107	214	6	-	-	HYPH
en-wikipedia-org-4107	214	7	release	release	NN
en-wikipedia-org-4107	214	8	and	and	CC
en-wikipedia-org-4107	214	9	extended	extended	JJ
en-wikipedia-org-4107	214	10	release	release	NN
en-wikipedia-org-4107	214	11	variants	variant	NNS
en-wikipedia-org-4107	214	12	of	of	IN
en-wikipedia-org-4107	214	13	salts	salt	NNS
en-wikipedia-org-4107	214	14	of	of	IN
en-wikipedia-org-4107	214	15	both	both	DT
en-wikipedia-org-4107	214	16	isomers	isomer	NNS
en-wikipedia-org-4107	214	17	reach	reach	VBP
en-wikipedia-org-4107	214	18	peak	peak	NN
en-wikipedia-org-4107	214	19	plasma	plasma	NN
en-wikipedia-org-4107	214	20	concentrations	concentration	NNS
en-wikipedia-org-4107	214	21	at	at	IN
en-wikipedia-org-4107	214	22	3	3	CD
en-wikipedia-org-4107	214	23	 	  	_SP
en-wikipedia-org-4107	214	24	hours	hour	NNS
en-wikipedia-org-4107	214	25	and	and	CC
en-wikipedia-org-4107	214	26	7	7	CD
en-wikipedia-org-4107	214	27	 	  	_SP
en-wikipedia-org-4107	214	28	hours	hour	NNS
en-wikipedia-org-4107	214	29	post	post	NN
en-wikipedia-org-4107	214	30	-	-	JJ
en-wikipedia-org-4107	214	31	dose	dose	VBP
en-wikipedia-org-4107	214	32	respectively	respectively	RB
en-wikipedia-org-4107	214	33	.	.	.
en-wikipedia-org-4107	215	1	[	[	-LRB-
en-wikipedia-org-4107	215	2	6	6	CD
en-wikipedia-org-4107	215	3	]	]	-RRB-
en-wikipedia-org-4107	215	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	215	5	is	be	VBZ
en-wikipedia-org-4107	215	6	eliminated	eliminate	VBN
en-wikipedia-org-4107	215	7	via	via	IN
en-wikipedia-org-4107	215	8	the	the	DT
en-wikipedia-org-4107	215	9	kidneys	kidney	NNS
en-wikipedia-org-4107	215	10	,	,	,
en-wikipedia-org-4107	215	11	with	with	IN
en-wikipedia-org-4107	215	12	30–40	30–40	CD
en-wikipedia-org-4107	215	13	%	%	NN
en-wikipedia-org-4107	215	14	of	of	IN
en-wikipedia-org-4107	215	15	the	the	DT
en-wikipedia-org-4107	215	16	drug	drug	NN
en-wikipedia-org-4107	215	17	being	be	VBG
en-wikipedia-org-4107	215	18	excreted	excrete	VBN
en-wikipedia-org-4107	215	19	unchanged	unchanged	JJ
en-wikipedia-org-4107	215	20	at	at	IN
en-wikipedia-org-4107	215	21	normal	normal	JJ
en-wikipedia-org-4107	215	22	urinary	urinary	NN
en-wikipedia-org-4107	215	23	pH.	pH.	NNP
en-wikipedia-org-4107	216	1	[	[	-LRB-
en-wikipedia-org-4107	216	2	6	6	CD
en-wikipedia-org-4107	216	3	]	]	-RRB-
en-wikipedia-org-4107	216	4	When	when	WRB
en-wikipedia-org-4107	216	5	the	the	DT
en-wikipedia-org-4107	216	6	urinary	urinary	NN
en-wikipedia-org-4107	216	7	pH	pH	NNP
en-wikipedia-org-4107	216	8	is	be	VBZ
en-wikipedia-org-4107	216	9	basic	basic	JJ
en-wikipedia-org-4107	216	10	,	,	,
en-wikipedia-org-4107	216	11	amphetamine	amphetamine	NN
en-wikipedia-org-4107	216	12	is	be	VBZ
en-wikipedia-org-4107	216	13	in	in	IN
en-wikipedia-org-4107	216	14	its	-PRON-	PRP$
en-wikipedia-org-4107	216	15	free	free	JJ
en-wikipedia-org-4107	216	16	base	base	NN
en-wikipedia-org-4107	216	17	form	form	NN
en-wikipedia-org-4107	216	18	,	,	,
en-wikipedia-org-4107	216	19	so	so	RB
en-wikipedia-org-4107	216	20	less	less	RBR
en-wikipedia-org-4107	216	21	is	be	VBZ
en-wikipedia-org-4107	216	22	excreted	excrete	VBN
en-wikipedia-org-4107	216	23	.	.	.
en-wikipedia-org-4107	217	1	[	[	-LRB-
en-wikipedia-org-4107	217	2	6	6	CD
en-wikipedia-org-4107	217	3	]	]	-RRB-
en-wikipedia-org-4107	217	4	When	when	WRB
en-wikipedia-org-4107	217	5	urine	urine	NN
en-wikipedia-org-4107	217	6	pH	pH	NNP
en-wikipedia-org-4107	217	7	is	be	VBZ
en-wikipedia-org-4107	217	8	abnormal	abnormal	JJ
en-wikipedia-org-4107	217	9	,	,	,
en-wikipedia-org-4107	217	10	the	the	DT
en-wikipedia-org-4107	217	11	urinary	urinary	JJ
en-wikipedia-org-4107	217	12	recovery	recovery	NN
en-wikipedia-org-4107	217	13	of	of	IN
en-wikipedia-org-4107	217	14	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	217	15	may	may	MD
en-wikipedia-org-4107	217	16	range	range	VB
en-wikipedia-org-4107	217	17	from	from	IN
en-wikipedia-org-4107	217	18	a	a	DT
en-wikipedia-org-4107	217	19	low	low	NN
en-wikipedia-org-4107	217	20	of	of	IN
en-wikipedia-org-4107	217	21	1	1	CD
en-wikipedia-org-4107	217	22	%	%	NN
en-wikipedia-org-4107	217	23	to	to	IN
en-wikipedia-org-4107	217	24	a	a	DT
en-wikipedia-org-4107	217	25	high	high	NN
en-wikipedia-org-4107	217	26	of	of	IN
en-wikipedia-org-4107	217	27	75	75	CD
en-wikipedia-org-4107	217	28	%	%	NN
en-wikipedia-org-4107	217	29	,	,	,
en-wikipedia-org-4107	217	30	depending	depend	VBG
en-wikipedia-org-4107	217	31	mostly	mostly	RB
en-wikipedia-org-4107	217	32	upon	upon	IN
en-wikipedia-org-4107	217	33	whether	whether	IN
en-wikipedia-org-4107	217	34	urine	urine	NN
en-wikipedia-org-4107	217	35	is	be	VBZ
en-wikipedia-org-4107	217	36	too	too	RB
en-wikipedia-org-4107	217	37	basic	basic	JJ
en-wikipedia-org-4107	217	38	or	or	CC
en-wikipedia-org-4107	217	39	acidic	acidic	JJ
en-wikipedia-org-4107	217	40	,	,	,
en-wikipedia-org-4107	217	41	respectively	respectively	RB
en-wikipedia-org-4107	217	42	.	.	.
en-wikipedia-org-4107	218	1	[	[	-LRB-
en-wikipedia-org-4107	218	2	6	6	CD
en-wikipedia-org-4107	218	3	]	]	-RRB-
en-wikipedia-org-4107	218	4	Following	follow	VBG
en-wikipedia-org-4107	218	5	oral	oral	JJ
en-wikipedia-org-4107	218	6	administration	administration	NN
en-wikipedia-org-4107	218	7	,	,	,
en-wikipedia-org-4107	218	8	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	218	9	appears	appear	VBZ
en-wikipedia-org-4107	218	10	in	in	IN
en-wikipedia-org-4107	218	11	urine	urine	NN
en-wikipedia-org-4107	218	12	within	within	IN
en-wikipedia-org-4107	218	13	3	3	CD
en-wikipedia-org-4107	218	14	 	  	_SP
en-wikipedia-org-4107	218	15	hours	hour	NNS
en-wikipedia-org-4107	218	16	.	.	.
en-wikipedia-org-4107	219	1	[	[	-LRB-
en-wikipedia-org-4107	219	2	12	12	CD
en-wikipedia-org-4107	219	3	]	]	-RRB-
en-wikipedia-org-4107	219	4	Roughly	roughly	RB
en-wikipedia-org-4107	219	5	90	90	CD
en-wikipedia-org-4107	219	6	%	%	NN
en-wikipedia-org-4107	219	7	of	of	IN
en-wikipedia-org-4107	219	8	ingested	ingested	JJ
en-wikipedia-org-4107	219	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	219	10	is	be	VBZ
en-wikipedia-org-4107	219	11	eliminated	eliminate	VBN
en-wikipedia-org-4107	219	12	3	3	CD
en-wikipedia-org-4107	219	13	 	  	_SP
en-wikipedia-org-4107	219	14	days	day	NNS
en-wikipedia-org-4107	219	15	after	after	IN
en-wikipedia-org-4107	219	16	the	the	DT
en-wikipedia-org-4107	219	17	last	last	JJ
en-wikipedia-org-4107	219	18	oral	oral	JJ
en-wikipedia-org-4107	219	19	dose	dose	NN
en-wikipedia-org-4107	219	20	.	.	.
en-wikipedia-org-4107	220	1	[	[	-LRB-
en-wikipedia-org-4107	220	2	12	12	CD
en-wikipedia-org-4107	220	3	]	]	-RRB-
en-wikipedia-org-4107	220	4	  	  	_SP
en-wikipedia-org-4107	220	5	The	the	DT
en-wikipedia-org-4107	220	6	prodrug	prodrug	NN
en-wikipedia-org-4107	220	7	lisdexamfetamine	lisdexamfetamine	NN
en-wikipedia-org-4107	220	8	is	be	VBZ
en-wikipedia-org-4107	220	9	not	not	RB
en-wikipedia-org-4107	220	10	as	as	RB
en-wikipedia-org-4107	220	11	sensitive	sensitive	JJ
en-wikipedia-org-4107	220	12	to	to	IN
en-wikipedia-org-4107	220	13	pH	pH	NNP
en-wikipedia-org-4107	220	14	as	as	IN
en-wikipedia-org-4107	220	15	amphetamine	amphetamine	NN
en-wikipedia-org-4107	220	16	when	when	WRB
en-wikipedia-org-4107	220	17	being	be	VBG
en-wikipedia-org-4107	220	18	absorbed	absorb	VBN
en-wikipedia-org-4107	220	19	in	in	IN
en-wikipedia-org-4107	220	20	the	the	DT
en-wikipedia-org-4107	220	21	gastrointestinal	gastrointestinal	JJ
en-wikipedia-org-4107	220	22	tract;[182	tract;[182	NNS
en-wikipedia-org-4107	220	23	]	]	-RRB-
en-wikipedia-org-4107	220	24	following	follow	VBG
en-wikipedia-org-4107	220	25	absorption	absorption	NN
en-wikipedia-org-4107	220	26	into	into	IN
en-wikipedia-org-4107	220	27	the	the	DT
en-wikipedia-org-4107	220	28	blood	blood	NN
en-wikipedia-org-4107	220	29	stream	stream	NN
en-wikipedia-org-4107	220	30	,	,	,
en-wikipedia-org-4107	220	31	it	-PRON-	PRP
en-wikipedia-org-4107	220	32	is	be	VBZ
en-wikipedia-org-4107	220	33	converted	convert	VBN
en-wikipedia-org-4107	220	34	by	by	IN
en-wikipedia-org-4107	220	35	red	red	JJ
en-wikipedia-org-4107	220	36	blood	blood	NN
en-wikipedia-org-4107	220	37	cell	cell	NN
en-wikipedia-org-4107	220	38	-	-	HYPH
en-wikipedia-org-4107	220	39	associated	associate	VBN
en-wikipedia-org-4107	220	40	enzymes	enzyme	NNS
en-wikipedia-org-4107	220	41	to	to	TO
en-wikipedia-org-4107	220	42	dextroamphetamine	dextroamphetamine	VB
en-wikipedia-org-4107	220	43	via	via	IN
en-wikipedia-org-4107	220	44	hydrolysis	hydrolysis	NN
en-wikipedia-org-4107	220	45	.	.	.
en-wikipedia-org-4107	221	1	[	[	-LRB-
en-wikipedia-org-4107	221	2	182	182	CD
en-wikipedia-org-4107	221	3	]	]	-RRB-
en-wikipedia-org-4107	221	4	The	the	DT
en-wikipedia-org-4107	221	5	elimination	elimination	NN
en-wikipedia-org-4107	221	6	half	half	JJ
en-wikipedia-org-4107	221	7	-	-	HYPH
en-wikipedia-org-4107	221	8	life	life	NN
en-wikipedia-org-4107	221	9	of	of	IN
en-wikipedia-org-4107	221	10	lisdexamfetamine	lisdexamfetamine	NN
en-wikipedia-org-4107	221	11	is	be	VBZ
en-wikipedia-org-4107	221	12	generally	generally	RB
en-wikipedia-org-4107	221	13	less	less	JJR
en-wikipedia-org-4107	221	14	than	than	IN
en-wikipedia-org-4107	221	15	1	1	CD
en-wikipedia-org-4107	221	16	 	  	_SP
en-wikipedia-org-4107	221	17	hour	hour	NN
en-wikipedia-org-4107	221	18	.	.	.
en-wikipedia-org-4107	222	1	[	[	-LRB-
en-wikipedia-org-4107	222	2	182	182	CD
en-wikipedia-org-4107	222	3	]	]	-RRB-
en-wikipedia-org-4107	222	4	CYP2D6	CYP2D6	NNP
en-wikipedia-org-4107	222	5	,	,	,
en-wikipedia-org-4107	222	6	dopamine	dopamine	NNP
en-wikipedia-org-4107	222	7	β	β	NNP
en-wikipedia-org-4107	222	8	-	-	HYPH
en-wikipedia-org-4107	222	9	hydroxylase	hydroxylase	NNP
en-wikipedia-org-4107	222	10	(	(	-LRB-
en-wikipedia-org-4107	222	11	DBH	DBH	NNP
en-wikipedia-org-4107	222	12	)	)	-RRB-
en-wikipedia-org-4107	222	13	,	,	,
en-wikipedia-org-4107	222	14	flavin	flavin	RB
en-wikipedia-org-4107	222	15	-	-	HYPH
en-wikipedia-org-4107	222	16	containing	contain	VBG
en-wikipedia-org-4107	222	17	monooxygenase	monooxygenase	NN
en-wikipedia-org-4107	222	18	3	3	CD
en-wikipedia-org-4107	222	19	(	(	-LRB-
en-wikipedia-org-4107	222	20	FMO3	FMO3	NNP
en-wikipedia-org-4107	222	21	)	)	-RRB-
en-wikipedia-org-4107	222	22	,	,	,
en-wikipedia-org-4107	222	23	butyrate	butyrate	NN
en-wikipedia-org-4107	222	24	-	-	HYPH
en-wikipedia-org-4107	222	25	CoA	coa	NN
en-wikipedia-org-4107	222	26	ligase	ligase	NN
en-wikipedia-org-4107	222	27	(	(	-LRB-
en-wikipedia-org-4107	222	28	XM	XM	NNP
en-wikipedia-org-4107	222	29	-	-	HYPH
en-wikipedia-org-4107	222	30	ligase	ligase	NNP
en-wikipedia-org-4107	222	31	)	)	-RRB-
en-wikipedia-org-4107	222	32	,	,	,
en-wikipedia-org-4107	222	33	and	and	CC
en-wikipedia-org-4107	222	34	glycine	glycine	NN
en-wikipedia-org-4107	222	35	N	N	NNP
en-wikipedia-org-4107	222	36	-	-	HYPH
en-wikipedia-org-4107	222	37	acyltransferase	acyltransferase	NN
en-wikipedia-org-4107	222	38	(	(	-LRB-
en-wikipedia-org-4107	222	39	GLYAT	GLYAT	NNP
en-wikipedia-org-4107	222	40	)	)	-RRB-
en-wikipedia-org-4107	222	41	are	be	VBP
en-wikipedia-org-4107	222	42	the	the	DT
en-wikipedia-org-4107	222	43	enzymes	enzyme	NNS
en-wikipedia-org-4107	222	44	known	know	VBN
en-wikipedia-org-4107	222	45	to	to	TO
en-wikipedia-org-4107	222	46	metabolize	metabolize	VB
en-wikipedia-org-4107	222	47	amphetamine	amphetamine	NN
en-wikipedia-org-4107	222	48	or	or	CC
en-wikipedia-org-4107	222	49	its	-PRON-	PRP$
en-wikipedia-org-4107	222	50	metabolites	metabolite	NNS
en-wikipedia-org-4107	222	51	in	in	IN
en-wikipedia-org-4107	222	52	humans	human	NNS
en-wikipedia-org-4107	222	53	.	.	.
en-wikipedia-org-4107	223	1	[	[	-LRB-
en-wikipedia-org-4107	223	2	sources	source	NNS
en-wikipedia-org-4107	223	3	16	16	CD
en-wikipedia-org-4107	223	4	]	]	-RRB-
en-wikipedia-org-4107	223	5	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	223	6	has	have	VBZ
en-wikipedia-org-4107	223	7	a	a	DT
en-wikipedia-org-4107	223	8	variety	variety	NN
en-wikipedia-org-4107	223	9	of	of	IN
en-wikipedia-org-4107	223	10	excreted	excreted	JJ
en-wikipedia-org-4107	223	11	metabolic	metabolic	JJ
en-wikipedia-org-4107	223	12	products	product	NNS
en-wikipedia-org-4107	223	13	,	,	,
en-wikipedia-org-4107	223	14	including	include	VBG
en-wikipedia-org-4107	223	15	4-hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	223	16	,	,	,
en-wikipedia-org-4107	223	17	4-hydroxynorephedrine	4-hydroxynorephedrine	CD
en-wikipedia-org-4107	223	18	,	,	,
en-wikipedia-org-4107	223	19	4-hydroxyphenylacetone	4-hydroxyphenylacetone	CD
en-wikipedia-org-4107	223	20	,	,	,
en-wikipedia-org-4107	223	21	benzoic	benzoic	NNP
en-wikipedia-org-4107	223	22	acid	acid	NN
en-wikipedia-org-4107	223	23	,	,	,
en-wikipedia-org-4107	223	24	hippuric	hippuric	NN
en-wikipedia-org-4107	223	25	acid	acid	NN
en-wikipedia-org-4107	223	26	,	,	,
en-wikipedia-org-4107	223	27	norephedrine	norephedrine	NN
en-wikipedia-org-4107	223	28	,	,	,
en-wikipedia-org-4107	223	29	and	and	CC
en-wikipedia-org-4107	223	30	phenylacetone	phenylacetone	NN
en-wikipedia-org-4107	223	31	.	.	.
en-wikipedia-org-4107	224	1	[	[	-LRB-
en-wikipedia-org-4107	224	2	6][7	6][7	LS
en-wikipedia-org-4107	224	3	]	]	-RRB-
en-wikipedia-org-4107	224	4	Among	among	IN
en-wikipedia-org-4107	224	5	these	these	DT
en-wikipedia-org-4107	224	6	metabolites	metabolite	NNS
en-wikipedia-org-4107	224	7	,	,	,
en-wikipedia-org-4107	224	8	the	the	DT
en-wikipedia-org-4107	224	9	active	active	JJ
en-wikipedia-org-4107	224	10	sympathomimetics	sympathomimetic	NNS
en-wikipedia-org-4107	224	11	are	be	VBP
en-wikipedia-org-4107	224	12	4-hydroxyamphetamine,[183	4-hydroxyamphetamine,[183	JJ
en-wikipedia-org-4107	224	13	]	]	-RRB-
en-wikipedia-org-4107	224	14	4-hydroxynorephedrine,[184	4-hydroxynorephedrine,[184	CD
en-wikipedia-org-4107	224	15	]	]	-RRB-
en-wikipedia-org-4107	224	16	and	and	CC
en-wikipedia-org-4107	224	17	norephedrine	norephedrine	NN
en-wikipedia-org-4107	224	18	.	.	.
en-wikipedia-org-4107	225	1	[	[	-LRB-
en-wikipedia-org-4107	225	2	185	185	CD
en-wikipedia-org-4107	225	3	]	]	-RRB-
en-wikipedia-org-4107	225	4	The	the	DT
en-wikipedia-org-4107	225	5	main	main	JJ
en-wikipedia-org-4107	225	6	metabolic	metabolic	JJ
en-wikipedia-org-4107	225	7	pathways	pathway	NNS
en-wikipedia-org-4107	225	8	involve	involve	VBP
en-wikipedia-org-4107	225	9	aromatic	aromatic	JJ
en-wikipedia-org-4107	225	10	para	para	NN
en-wikipedia-org-4107	225	11	-	-	HYPH
en-wikipedia-org-4107	225	12	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	225	13	,	,	,
en-wikipedia-org-4107	225	14	aliphatic	aliphatic	JJ
en-wikipedia-org-4107	225	15	alpha-	alpha-	NN
en-wikipedia-org-4107	225	16	and	and	CC
en-wikipedia-org-4107	225	17	beta	beta	NN
en-wikipedia-org-4107	225	18	-	-	HYPH
en-wikipedia-org-4107	225	19	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	225	20	,	,	,
en-wikipedia-org-4107	225	21	N	n	NN
en-wikipedia-org-4107	225	22	-	-	HYPH
en-wikipedia-org-4107	225	23	oxidation	oxidation	NN
en-wikipedia-org-4107	225	24	,	,	,
en-wikipedia-org-4107	225	25	N	n	NN
en-wikipedia-org-4107	225	26	-	-	HYPH
en-wikipedia-org-4107	225	27	dealkylation	dealkylation	NN
en-wikipedia-org-4107	225	28	,	,	,
en-wikipedia-org-4107	225	29	and	and	CC
en-wikipedia-org-4107	225	30	deamination	deamination	NN
en-wikipedia-org-4107	225	31	.	.	.
en-wikipedia-org-4107	226	1	[	[	-LRB-
en-wikipedia-org-4107	226	2	6][186	6][186	CD
en-wikipedia-org-4107	226	3	]	]	-RRB-
en-wikipedia-org-4107	226	4	The	the	DT
en-wikipedia-org-4107	226	5	known	know	VBN
en-wikipedia-org-4107	226	6	metabolic	metabolic	JJ
en-wikipedia-org-4107	226	7	pathways	pathway	NNS
en-wikipedia-org-4107	226	8	,	,	,
en-wikipedia-org-4107	226	9	detectable	detectable	JJ
en-wikipedia-org-4107	226	10	metabolites	metabolite	NNS
en-wikipedia-org-4107	226	11	,	,	,
en-wikipedia-org-4107	226	12	and	and	CC
en-wikipedia-org-4107	226	13	metabolizing	metabolizing	JJ
en-wikipedia-org-4107	226	14	enzymes	enzyme	NNS
en-wikipedia-org-4107	226	15	in	in	IN
en-wikipedia-org-4107	226	16	humans	human	NNS
en-wikipedia-org-4107	226	17	include	include	VBP
en-wikipedia-org-4107	226	18	the	the	DT
en-wikipedia-org-4107	226	19	following	follow	VBG
en-wikipedia-org-4107	226	20	:	:	:
en-wikipedia-org-4107	226	21	Metabolic	metabolic	JJ
en-wikipedia-org-4107	226	22	pathways	pathway	NNS
en-wikipedia-org-4107	226	23	of	of	IN
en-wikipedia-org-4107	226	24	amphetamine	amphetamine	NN
en-wikipedia-org-4107	226	25	in	in	IN
en-wikipedia-org-4107	226	26	humans[sources	humans[sources	NNP
en-wikipedia-org-4107	226	27	16	16	CD
en-wikipedia-org-4107	226	28	]	]	-RRB-
en-wikipedia-org-4107	226	29	4-Hydroxyphenylacetone	4-hydroxyphenylacetone	CD
en-wikipedia-org-4107	226	30	Phenylacetone	Phenylacetone	NNP
en-wikipedia-org-4107	226	31	Benzoic	Benzoic	NNP
en-wikipedia-org-4107	226	32	acid	acid	NN
en-wikipedia-org-4107	226	33	Hippuric	hippuric	JJ
en-wikipedia-org-4107	226	34	acid	acid	NN
en-wikipedia-org-4107	226	35	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	226	36	Norephedrine	Norephedrine	NNP
en-wikipedia-org-4107	226	37	4-Hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	226	38	4-Hydroxynorephedrine	4-hydroxynorephedrine	CD
en-wikipedia-org-4107	226	39	Para-	Para-	NNP
en-wikipedia-org-4107	226	40	Hydroxylation	Hydroxylation	NNP
en-wikipedia-org-4107	226	41	Para-	Para-	NNP
en-wikipedia-org-4107	226	42	Hydroxylation	Hydroxylation	NNP
en-wikipedia-org-4107	226	43	Para-	Para-	NNP
en-wikipedia-org-4107	226	44	Hydroxylation	Hydroxylation	NNP
en-wikipedia-org-4107	226	45	CYP2D6	CYP2D6	NNP
en-wikipedia-org-4107	226	46	CYP2D6	CYP2D6	NNP
en-wikipedia-org-4107	226	47	unidentified	unidentified	JJ
en-wikipedia-org-4107	226	48	Beta-	beta-	JJ
en-wikipedia-org-4107	226	49	Hydroxylation	Hydroxylation	NNP
en-wikipedia-org-4107	226	50	Beta-	Beta-	NNP
en-wikipedia-org-4107	226	51	Hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	226	52	DBH	DBH	NNP
en-wikipedia-org-4107	226	53	DBH	DBH	NNP
en-wikipedia-org-4107	226	54	[	[	-LRB-
en-wikipedia-org-4107	226	55	note	note	VBP
en-wikipedia-org-4107	226	56	17	17	CD
en-wikipedia-org-4107	226	57	]	]	-RRB-
en-wikipedia-org-4107	226	58	Oxidative	Oxidative	NNP
en-wikipedia-org-4107	226	59	Deamination	Deamination	NNP
en-wikipedia-org-4107	226	60	FMO3	FMO3	NNP
en-wikipedia-org-4107	226	61	Oxidation	Oxidation	NNP
en-wikipedia-org-4107	226	62	unidentified	unidentified	JJ
en-wikipedia-org-4107	226	63	Glycine	Glycine	NNP
en-wikipedia-org-4107	226	64	Conjugation	Conjugation	NNP
en-wikipedia-org-4107	226	65	XM	XM	NNP
en-wikipedia-org-4107	226	66	-	-	HYPH
en-wikipedia-org-4107	226	67	ligase	ligase	NN
en-wikipedia-org-4107	226	68	GLYAT	GLYAT	NNP
en-wikipedia-org-4107	226	69	The	the	DT
en-wikipedia-org-4107	226	70	primary	primary	JJ
en-wikipedia-org-4107	226	71	active	active	JJ
en-wikipedia-org-4107	226	72	metabolites	metabolite	NNS
en-wikipedia-org-4107	226	73	of	of	IN
en-wikipedia-org-4107	226	74	amphetamine	amphetamine	NN
en-wikipedia-org-4107	226	75	are	be	VBP
en-wikipedia-org-4107	226	76	4-hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	226	77	and	and	CC
en-wikipedia-org-4107	226	78	norephedrine;[7	norephedrine;[7	NNP
en-wikipedia-org-4107	226	79	]	]	-RRB-
en-wikipedia-org-4107	226	80	at	at	IN
en-wikipedia-org-4107	226	81	normal	normal	JJ
en-wikipedia-org-4107	226	82	urine	urine	NN
en-wikipedia-org-4107	226	83	pH	pH	NNP
en-wikipedia-org-4107	226	84	,	,	,
en-wikipedia-org-4107	226	85	about	about	RB
en-wikipedia-org-4107	226	86	30–40	30–40	CD
en-wikipedia-org-4107	226	87	%	%	NN
en-wikipedia-org-4107	226	88	of	of	IN
en-wikipedia-org-4107	226	89	amphetamine	amphetamine	NN
en-wikipedia-org-4107	226	90	is	be	VBZ
en-wikipedia-org-4107	226	91	excreted	excrete	VBN
en-wikipedia-org-4107	226	92	unchanged	unchanged	JJ
en-wikipedia-org-4107	226	93	and	and	CC
en-wikipedia-org-4107	226	94	roughly	roughly	RB
en-wikipedia-org-4107	226	95	50	50	CD
en-wikipedia-org-4107	226	96	%	%	NN
en-wikipedia-org-4107	226	97	is	be	VBZ
en-wikipedia-org-4107	226	98	excreted	excrete	VBN
en-wikipedia-org-4107	226	99	as	as	IN
en-wikipedia-org-4107	226	100	the	the	DT
en-wikipedia-org-4107	226	101	inactive	inactive	JJ
en-wikipedia-org-4107	226	102	metabolites	metabolite	NNS
en-wikipedia-org-4107	226	103	(	(	-LRB-
en-wikipedia-org-4107	226	104	bottom	bottom	JJ
en-wikipedia-org-4107	226	105	row	row	NN
en-wikipedia-org-4107	226	106	)	)	-RRB-
en-wikipedia-org-4107	226	107	.	.	.
en-wikipedia-org-4107	227	1	[	[	-LRB-
en-wikipedia-org-4107	227	2	6	6	CD
en-wikipedia-org-4107	227	3	]	]	-RRB-
en-wikipedia-org-4107	227	4	The	the	DT
en-wikipedia-org-4107	227	5	remaining	remain	VBG
en-wikipedia-org-4107	227	6	10–20	10–20	CD
en-wikipedia-org-4107	227	7	%	%	NN
en-wikipedia-org-4107	227	8	is	be	VBZ
en-wikipedia-org-4107	227	9	excreted	excrete	VBN
en-wikipedia-org-4107	227	10	as	as	IN
en-wikipedia-org-4107	227	11	the	the	DT
en-wikipedia-org-4107	227	12	active	active	JJ
en-wikipedia-org-4107	227	13	metabolites	metabolite	NNS
en-wikipedia-org-4107	227	14	.	.	.
en-wikipedia-org-4107	228	1	[	[	-LRB-
en-wikipedia-org-4107	228	2	6	6	CD
en-wikipedia-org-4107	228	3	]	]	-RRB-
en-wikipedia-org-4107	228	4	Benzoic	Benzoic	NNP
en-wikipedia-org-4107	228	5	acid	acid	NN
en-wikipedia-org-4107	228	6	is	be	VBZ
en-wikipedia-org-4107	228	7	metabolized	metabolize	VBN
en-wikipedia-org-4107	228	8	by	by	IN
en-wikipedia-org-4107	228	9	XM	xm	NN
en-wikipedia-org-4107	228	10	-	-	HYPH
en-wikipedia-org-4107	228	11	ligase	ligase	NN
en-wikipedia-org-4107	228	12	into	into	IN
en-wikipedia-org-4107	228	13	an	an	DT
en-wikipedia-org-4107	228	14	intermediate	intermediate	JJ
en-wikipedia-org-4107	228	15	product	product	NN
en-wikipedia-org-4107	228	16	,	,	,
en-wikipedia-org-4107	228	17	benzoyl	benzoyl	NN
en-wikipedia-org-4107	228	18	-	-	HYPH
en-wikipedia-org-4107	228	19	CoA	CoA	NNP
en-wikipedia-org-4107	228	20	,	,	,
en-wikipedia-org-4107	228	21	which	which	WDT
en-wikipedia-org-4107	228	22	is	be	VBZ
en-wikipedia-org-4107	228	23	then	then	RB
en-wikipedia-org-4107	228	24	metabolized	metabolize	VBN
en-wikipedia-org-4107	228	25	by	by	IN
en-wikipedia-org-4107	228	26	GLYAT	GLYAT	NNP
en-wikipedia-org-4107	228	27	into	into	IN
en-wikipedia-org-4107	228	28	hippuric	hippuric	NN
en-wikipedia-org-4107	228	29	acid	acid	NN
en-wikipedia-org-4107	228	30	.	.	.
en-wikipedia-org-4107	229	1	[	[	-LRB-
en-wikipedia-org-4107	229	2	188	188	CD
en-wikipedia-org-4107	229	3	]	]	-RRB-
en-wikipedia-org-4107	229	4	Pharmacomicrobiomics	Pharmacomicrobiomics	NNP
en-wikipedia-org-4107	229	5	The	the	DT
en-wikipedia-org-4107	229	6	human	human	JJ
en-wikipedia-org-4107	229	7	metagenome	metagenome	NN
en-wikipedia-org-4107	229	8	(	(	-LRB-
en-wikipedia-org-4107	229	9	i.e.	i.e.	FW
en-wikipedia-org-4107	229	10	,	,	,
en-wikipedia-org-4107	229	11	the	the	DT
en-wikipedia-org-4107	229	12	genetic	genetic	JJ
en-wikipedia-org-4107	229	13	composition	composition	NN
en-wikipedia-org-4107	229	14	of	of	IN
en-wikipedia-org-4107	229	15	an	an	DT
en-wikipedia-org-4107	229	16	individual	individual	NN
en-wikipedia-org-4107	229	17	and	and	CC
en-wikipedia-org-4107	229	18	all	all	DT
en-wikipedia-org-4107	229	19	microorganisms	microorganism	NNS
en-wikipedia-org-4107	229	20	that	that	WDT
en-wikipedia-org-4107	229	21	reside	reside	VBP
en-wikipedia-org-4107	229	22	on	on	IN
en-wikipedia-org-4107	229	23	or	or	CC
en-wikipedia-org-4107	229	24	within	within	IN
en-wikipedia-org-4107	229	25	the	the	DT
en-wikipedia-org-4107	229	26	individual	individual	NN
en-wikipedia-org-4107	229	27	's	's	POS
en-wikipedia-org-4107	229	28	body	body	NN
en-wikipedia-org-4107	229	29	)	)	-RRB-
en-wikipedia-org-4107	229	30	varies	vary	VBZ
en-wikipedia-org-4107	229	31	considerably	considerably	RB
en-wikipedia-org-4107	229	32	between	between	IN
en-wikipedia-org-4107	229	33	individuals	individual	NNS
en-wikipedia-org-4107	229	34	.	.	.
en-wikipedia-org-4107	230	1	[	[	-LRB-
en-wikipedia-org-4107	230	2	192][193	192][193	CD
en-wikipedia-org-4107	230	3	]	]	-RRB-
en-wikipedia-org-4107	230	4	Since	since	IN
en-wikipedia-org-4107	230	5	the	the	DT
en-wikipedia-org-4107	230	6	total	total	JJ
en-wikipedia-org-4107	230	7	number	number	NN
en-wikipedia-org-4107	230	8	of	of	IN
en-wikipedia-org-4107	230	9	microbial	microbial	JJ
en-wikipedia-org-4107	230	10	and	and	CC
en-wikipedia-org-4107	230	11	viral	viral	JJ
en-wikipedia-org-4107	230	12	cells	cell	NNS
en-wikipedia-org-4107	230	13	in	in	IN
en-wikipedia-org-4107	230	14	the	the	DT
en-wikipedia-org-4107	230	15	human	human	JJ
en-wikipedia-org-4107	230	16	body	body	NN
en-wikipedia-org-4107	230	17	(	(	-LRB-
en-wikipedia-org-4107	230	18	over	over	IN
en-wikipedia-org-4107	230	19	100	100	CD
en-wikipedia-org-4107	230	20	 	  	_SP
en-wikipedia-org-4107	230	21	trillion	trillion	CD
en-wikipedia-org-4107	230	22	)	)	-RRB-
en-wikipedia-org-4107	230	23	greatly	greatly	RB
en-wikipedia-org-4107	230	24	outnumbers	outnumber	VBZ
en-wikipedia-org-4107	230	25	human	human	JJ
en-wikipedia-org-4107	230	26	cells	cell	NNS
en-wikipedia-org-4107	230	27	(	(	-LRB-
en-wikipedia-org-4107	230	28	tens	ten	NNS
en-wikipedia-org-4107	230	29	of	of	IN
en-wikipedia-org-4107	230	30	trillions),[note	trillions),[note	NNP
en-wikipedia-org-4107	230	31	18][192][194	18][192][194	CD
en-wikipedia-org-4107	230	32	]	]	-RRB-
en-wikipedia-org-4107	230	33	there	there	EX
en-wikipedia-org-4107	230	34	is	be	VBZ
en-wikipedia-org-4107	230	35	considerable	considerable	JJ
en-wikipedia-org-4107	230	36	potential	potential	NN
en-wikipedia-org-4107	230	37	for	for	IN
en-wikipedia-org-4107	230	38	interactions	interaction	NNS
en-wikipedia-org-4107	230	39	between	between	IN
en-wikipedia-org-4107	230	40	drugs	drug	NNS
en-wikipedia-org-4107	230	41	and	and	CC
en-wikipedia-org-4107	230	42	an	an	DT
en-wikipedia-org-4107	230	43	individual	individual	NN
en-wikipedia-org-4107	230	44	's	's	POS
en-wikipedia-org-4107	230	45	microbiome	microbiome	NN
en-wikipedia-org-4107	230	46	,	,	,
en-wikipedia-org-4107	230	47	including	include	VBG
en-wikipedia-org-4107	230	48	:	:	:
en-wikipedia-org-4107	230	49	drugs	drug	NNS
en-wikipedia-org-4107	230	50	altering	alter	VBG
en-wikipedia-org-4107	230	51	the	the	DT
en-wikipedia-org-4107	230	52	composition	composition	NN
en-wikipedia-org-4107	230	53	of	of	IN
en-wikipedia-org-4107	230	54	the	the	DT
en-wikipedia-org-4107	230	55	human	human	JJ
en-wikipedia-org-4107	230	56	microbiome	microbiome	NN
en-wikipedia-org-4107	230	57	,	,	,
en-wikipedia-org-4107	230	58	drug	drug	NN
en-wikipedia-org-4107	230	59	metabolism	metabolism	NN
en-wikipedia-org-4107	230	60	by	by	IN
en-wikipedia-org-4107	230	61	microbial	microbial	JJ
en-wikipedia-org-4107	230	62	enzymes	enzyme	NNS
en-wikipedia-org-4107	230	63	modifying	modify	VBG
en-wikipedia-org-4107	230	64	the	the	DT
en-wikipedia-org-4107	230	65	drug	drug	NN
en-wikipedia-org-4107	230	66	's	's	POS
en-wikipedia-org-4107	230	67	pharmacokinetic	pharmacokinetic	JJ
en-wikipedia-org-4107	230	68	profile	profile	NN
en-wikipedia-org-4107	230	69	,	,	,
en-wikipedia-org-4107	230	70	and	and	CC
en-wikipedia-org-4107	230	71	microbial	microbial	JJ
en-wikipedia-org-4107	230	72	drug	drug	NN
en-wikipedia-org-4107	230	73	metabolism	metabolism	NN
en-wikipedia-org-4107	230	74	affecting	affect	VBG
en-wikipedia-org-4107	230	75	a	a	DT
en-wikipedia-org-4107	230	76	drug	drug	NN
en-wikipedia-org-4107	230	77	's	's	POS
en-wikipedia-org-4107	230	78	clinical	clinical	JJ
en-wikipedia-org-4107	230	79	efficacy	efficacy	NN
en-wikipedia-org-4107	230	80	and	and	CC
en-wikipedia-org-4107	230	81	toxicity	toxicity	NN
en-wikipedia-org-4107	230	82	profile	profile	NN
en-wikipedia-org-4107	230	83	.	.	.
en-wikipedia-org-4107	231	1	[	[	-LRB-
en-wikipedia-org-4107	231	2	192][193][195	192][193][195	LS
en-wikipedia-org-4107	231	3	]	]	-RRB-
en-wikipedia-org-4107	231	4	The	the	DT
en-wikipedia-org-4107	231	5	field	field	NN
en-wikipedia-org-4107	231	6	that	that	WDT
en-wikipedia-org-4107	231	7	studies	study	VBZ
en-wikipedia-org-4107	231	8	these	these	DT
en-wikipedia-org-4107	231	9	interactions	interaction	NNS
en-wikipedia-org-4107	231	10	is	be	VBZ
en-wikipedia-org-4107	231	11	known	know	VBN
en-wikipedia-org-4107	231	12	as	as	IN
en-wikipedia-org-4107	231	13	pharmacomicrobiomics	pharmacomicrobiomic	NNS
en-wikipedia-org-4107	231	14	.	.	.
en-wikipedia-org-4107	232	1	[	[	-LRB-
en-wikipedia-org-4107	232	2	192	192	CD
en-wikipedia-org-4107	232	3	]	]	-RRB-
en-wikipedia-org-4107	232	4	Similar	similar	JJ
en-wikipedia-org-4107	232	5	to	to	IN
en-wikipedia-org-4107	232	6	most	most	JJS
en-wikipedia-org-4107	232	7	biomolecules	biomolecule	NNS
en-wikipedia-org-4107	232	8	and	and	CC
en-wikipedia-org-4107	232	9	other	other	JJ
en-wikipedia-org-4107	232	10	orally	orally	RB
en-wikipedia-org-4107	232	11	administered	administer	VBN
en-wikipedia-org-4107	232	12	xenobiotics	xenobiotic	NNS
en-wikipedia-org-4107	232	13	(	(	-LRB-
en-wikipedia-org-4107	232	14	i.e.	i.e.	FW
en-wikipedia-org-4107	232	15	,	,	,
en-wikipedia-org-4107	232	16	drugs	drug	NNS
en-wikipedia-org-4107	232	17	)	)	-RRB-
en-wikipedia-org-4107	232	18	,	,	,
en-wikipedia-org-4107	232	19	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	232	20	is	be	VBZ
en-wikipedia-org-4107	232	21	predicted	predict	VBN
en-wikipedia-org-4107	232	22	to	to	TO
en-wikipedia-org-4107	232	23	undergo	undergo	VB
en-wikipedia-org-4107	232	24	promiscuous	promiscuous	JJ
en-wikipedia-org-4107	232	25	metabolism	metabolism	NN
en-wikipedia-org-4107	232	26	by	by	IN
en-wikipedia-org-4107	232	27	human	human	JJ
en-wikipedia-org-4107	232	28	gastrointestinal	gastrointestinal	JJ
en-wikipedia-org-4107	232	29	microbiota	microbiota	NN
en-wikipedia-org-4107	232	30	(	(	-LRB-
en-wikipedia-org-4107	232	31	primarily	primarily	RB
en-wikipedia-org-4107	232	32	bacteria	bacteria	NNS
en-wikipedia-org-4107	232	33	)	)	-RRB-
en-wikipedia-org-4107	232	34	prior	prior	RB
en-wikipedia-org-4107	232	35	to	to	IN
en-wikipedia-org-4107	232	36	absorption	absorption	NN
en-wikipedia-org-4107	232	37	into	into	IN
en-wikipedia-org-4107	232	38	the	the	DT
en-wikipedia-org-4107	232	39	blood	blood	NN
en-wikipedia-org-4107	232	40	stream	stream	NN
en-wikipedia-org-4107	232	41	.	.	.
en-wikipedia-org-4107	233	1	[	[	-LRB-
en-wikipedia-org-4107	233	2	195	195	CD
en-wikipedia-org-4107	233	3	]	]	-RRB-
en-wikipedia-org-4107	233	4	The	the	DT
en-wikipedia-org-4107	233	5	first	first	JJ
en-wikipedia-org-4107	233	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	233	7	-	-	HYPH
en-wikipedia-org-4107	233	8	metabolizing	metabolize	VBG
en-wikipedia-org-4107	233	9	microbial	microbial	JJ
en-wikipedia-org-4107	233	10	enzyme	enzyme	NNS
en-wikipedia-org-4107	233	11	,	,	,
en-wikipedia-org-4107	233	12	tyramine	tyramine	NNP
en-wikipedia-org-4107	233	13	oxidase	oxidase	NN
en-wikipedia-org-4107	233	14	from	from	IN
en-wikipedia-org-4107	233	15	a	a	DT
en-wikipedia-org-4107	233	16	strain	strain	NN
en-wikipedia-org-4107	233	17	of	of	IN
en-wikipedia-org-4107	233	18	E.	E.	NNP
en-wikipedia-org-4107	233	19	coli	coli	NNS
en-wikipedia-org-4107	233	20	commonly	commonly	RB
en-wikipedia-org-4107	233	21	found	find	VBN
en-wikipedia-org-4107	233	22	in	in	IN
en-wikipedia-org-4107	233	23	the	the	DT
en-wikipedia-org-4107	233	24	human	human	JJ
en-wikipedia-org-4107	233	25	gut	gut	NN
en-wikipedia-org-4107	233	26	,	,	,
en-wikipedia-org-4107	233	27	was	be	VBD
en-wikipedia-org-4107	233	28	identified	identify	VBN
en-wikipedia-org-4107	233	29	in	in	IN
en-wikipedia-org-4107	233	30	2019	2019	CD
en-wikipedia-org-4107	233	31	.	.	.
en-wikipedia-org-4107	234	1	[	[	-LRB-
en-wikipedia-org-4107	234	2	195	195	CD
en-wikipedia-org-4107	234	3	]	]	-RRB-
en-wikipedia-org-4107	234	4	This	this	DT
en-wikipedia-org-4107	234	5	enzyme	enzyme	NNS
en-wikipedia-org-4107	234	6	was	be	VBD
en-wikipedia-org-4107	234	7	found	find	VBN
en-wikipedia-org-4107	234	8	to	to	TO
en-wikipedia-org-4107	234	9	metabolize	metabolize	VB
en-wikipedia-org-4107	234	10	amphetamine	amphetamine	NN
en-wikipedia-org-4107	234	11	,	,	,
en-wikipedia-org-4107	234	12	tyramine	tyramine	NN
en-wikipedia-org-4107	234	13	,	,	,
en-wikipedia-org-4107	234	14	and	and	CC
en-wikipedia-org-4107	234	15	phenethylamine	phenethylamine	VB
en-wikipedia-org-4107	234	16	with	with	IN
en-wikipedia-org-4107	234	17	roughly	roughly	RB
en-wikipedia-org-4107	234	18	the	the	DT
en-wikipedia-org-4107	234	19	same	same	JJ
en-wikipedia-org-4107	234	20	binding	binding	NN
en-wikipedia-org-4107	234	21	affinity	affinity	NN
en-wikipedia-org-4107	234	22	for	for	IN
en-wikipedia-org-4107	234	23	all	all	DT
en-wikipedia-org-4107	234	24	three	three	CD
en-wikipedia-org-4107	234	25	compounds	compound	NNS
en-wikipedia-org-4107	234	26	.	.	.
en-wikipedia-org-4107	235	1	[	[	-LRB-
en-wikipedia-org-4107	235	2	195	195	CD
en-wikipedia-org-4107	235	3	]	]	-RRB-
en-wikipedia-org-4107	235	4	Related	relate	VBN
en-wikipedia-org-4107	235	5	endogenous	endogenous	JJ
en-wikipedia-org-4107	235	6	compounds	compound	NNS
en-wikipedia-org-4107	235	7	Further	further	JJ
en-wikipedia-org-4107	235	8	information	information	NN
en-wikipedia-org-4107	235	9	on	on	IN
en-wikipedia-org-4107	235	10	related	related	JJ
en-wikipedia-org-4107	235	11	compounds	compound	NNS
en-wikipedia-org-4107	235	12	:	:	:
en-wikipedia-org-4107	235	13	Trace	Trace	NNP
en-wikipedia-org-4107	235	14	amine	amine	NN
en-wikipedia-org-4107	235	15	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	235	16	has	have	VBZ
en-wikipedia-org-4107	235	17	a	a	DT
en-wikipedia-org-4107	235	18	very	very	RB
en-wikipedia-org-4107	235	19	similar	similar	JJ
en-wikipedia-org-4107	235	20	structure	structure	NN
en-wikipedia-org-4107	235	21	and	and	CC
en-wikipedia-org-4107	235	22	function	function	NN
en-wikipedia-org-4107	235	23	to	to	IN
en-wikipedia-org-4107	235	24	the	the	DT
en-wikipedia-org-4107	235	25	endogenous	endogenous	JJ
en-wikipedia-org-4107	235	26	trace	trace	NN
en-wikipedia-org-4107	235	27	amines	amine	NNS
en-wikipedia-org-4107	235	28	,	,	,
en-wikipedia-org-4107	235	29	which	which	WDT
en-wikipedia-org-4107	235	30	are	be	VBP
en-wikipedia-org-4107	235	31	naturally	naturally	RB
en-wikipedia-org-4107	235	32	occurring	occur	VBG
en-wikipedia-org-4107	235	33	neuromodulator	neuromodulator	NN
en-wikipedia-org-4107	235	34	molecules	molecule	NNS
en-wikipedia-org-4107	235	35	produced	produce	VBN
en-wikipedia-org-4107	235	36	in	in	IN
en-wikipedia-org-4107	235	37	the	the	DT
en-wikipedia-org-4107	235	38	human	human	JJ
en-wikipedia-org-4107	235	39	body	body	NN
en-wikipedia-org-4107	235	40	and	and	CC
en-wikipedia-org-4107	235	41	brain	brain	NN
en-wikipedia-org-4107	235	42	.	.	.
en-wikipedia-org-4107	236	1	[	[	-LRB-
en-wikipedia-org-4107	236	2	37][46][196	37][46][196	CD
en-wikipedia-org-4107	236	3	]	]	-RRB-
en-wikipedia-org-4107	236	4	Among	among	IN
en-wikipedia-org-4107	236	5	this	this	DT
en-wikipedia-org-4107	236	6	group	group	NN
en-wikipedia-org-4107	236	7	,	,	,
en-wikipedia-org-4107	236	8	the	the	DT
en-wikipedia-org-4107	236	9	most	most	RBS
en-wikipedia-org-4107	236	10	closely	closely	RB
en-wikipedia-org-4107	236	11	related	relate	VBN
en-wikipedia-org-4107	236	12	compounds	compound	NNS
en-wikipedia-org-4107	236	13	are	be	VBP
en-wikipedia-org-4107	236	14	phenethylamine	phenethylamine	NN
en-wikipedia-org-4107	236	15	,	,	,
en-wikipedia-org-4107	236	16	the	the	DT
en-wikipedia-org-4107	236	17	parent	parent	NN
en-wikipedia-org-4107	236	18	compound	compound	NN
en-wikipedia-org-4107	236	19	of	of	IN
en-wikipedia-org-4107	236	20	amphetamine	amphetamine	NN
en-wikipedia-org-4107	236	21	,	,	,
en-wikipedia-org-4107	236	22	and	and	CC
en-wikipedia-org-4107	236	23	N	N	NNP
en-wikipedia-org-4107	236	24	-	-	HYPH
en-wikipedia-org-4107	236	25	methylphenethylamine	methylphenethylamine	NNP
en-wikipedia-org-4107	236	26	,	,	,
en-wikipedia-org-4107	236	27	an	an	DT
en-wikipedia-org-4107	236	28	isomer	isomer	NN
en-wikipedia-org-4107	236	29	of	of	IN
en-wikipedia-org-4107	236	30	amphetamine	amphetamine	NN
en-wikipedia-org-4107	236	31	(	(	-LRB-
en-wikipedia-org-4107	236	32	i.e.	i.e.	FW
en-wikipedia-org-4107	236	33	,	,	,
en-wikipedia-org-4107	236	34	it	-PRON-	PRP
en-wikipedia-org-4107	236	35	has	have	VBZ
en-wikipedia-org-4107	236	36	an	an	DT
en-wikipedia-org-4107	236	37	identical	identical	JJ
en-wikipedia-org-4107	236	38	molecular	molecular	JJ
en-wikipedia-org-4107	236	39	formula	formula	NN
en-wikipedia-org-4107	236	40	)	)	-RRB-
en-wikipedia-org-4107	236	41	.	.	.
en-wikipedia-org-4107	237	1	[	[	-LRB-
en-wikipedia-org-4107	237	2	37][46][197	37][46][197	CD
en-wikipedia-org-4107	237	3	]	]	-RRB-
en-wikipedia-org-4107	237	4	In	in	IN
en-wikipedia-org-4107	237	5	humans	human	NNS
en-wikipedia-org-4107	237	6	,	,	,
en-wikipedia-org-4107	237	7	phenethylamine	phenethylamine	NN
en-wikipedia-org-4107	237	8	is	be	VBZ
en-wikipedia-org-4107	237	9	produced	produce	VBN
en-wikipedia-org-4107	237	10	directly	directly	RB
en-wikipedia-org-4107	237	11	from	from	IN
en-wikipedia-org-4107	237	12	L	l	NN
en-wikipedia-org-4107	237	13	-	-	HYPH
en-wikipedia-org-4107	237	14	phenylalanine	phenylalanine	NN
en-wikipedia-org-4107	237	15	by	by	IN
en-wikipedia-org-4107	237	16	the	the	DT
en-wikipedia-org-4107	237	17	aromatic	aromatic	JJ
en-wikipedia-org-4107	237	18	amino	amino	NN
en-wikipedia-org-4107	237	19	acid	acid	NN
en-wikipedia-org-4107	237	20	decarboxylase	decarboxylase	NNP
en-wikipedia-org-4107	237	21	(	(	-LRB-
en-wikipedia-org-4107	237	22	AADC	AADC	NNP
en-wikipedia-org-4107	237	23	)	)	-RRB-
en-wikipedia-org-4107	237	24	enzyme	enzyme	NNS
en-wikipedia-org-4107	237	25	,	,	,
en-wikipedia-org-4107	237	26	which	which	WDT
en-wikipedia-org-4107	237	27	converts	convert	VBZ
en-wikipedia-org-4107	237	28	L	l	NN
en-wikipedia-org-4107	237	29	-	-	HYPH
en-wikipedia-org-4107	237	30	DOPA	DOPA	NNP
en-wikipedia-org-4107	237	31	into	into	IN
en-wikipedia-org-4107	237	32	dopamine	dopamine	NN
en-wikipedia-org-4107	237	33	as	as	RB
en-wikipedia-org-4107	237	34	well	well	RB
en-wikipedia-org-4107	237	35	.	.	.
en-wikipedia-org-4107	238	1	[	[	-LRB-
en-wikipedia-org-4107	238	2	46][197	46][197	NNP
en-wikipedia-org-4107	238	3	]	]	-RRB-
en-wikipedia-org-4107	238	4	In	in	IN
en-wikipedia-org-4107	238	5	turn	turn	NN
en-wikipedia-org-4107	238	6	,	,	,
en-wikipedia-org-4107	238	7	N	N	NNP
en-wikipedia-org-4107	238	8	-	-	HYPH
en-wikipedia-org-4107	238	9	methylphenethylamine	methylphenethylamine	NN
en-wikipedia-org-4107	238	10	is	be	VBZ
en-wikipedia-org-4107	238	11	metabolized	metabolize	VBN
en-wikipedia-org-4107	238	12	from	from	IN
en-wikipedia-org-4107	238	13	phenethylamine	phenethylamine	NN
en-wikipedia-org-4107	238	14	by	by	IN
en-wikipedia-org-4107	238	15	phenylethanolamine	phenylethanolamine	NN
en-wikipedia-org-4107	238	16	N	N	NNP
en-wikipedia-org-4107	238	17	-	-	HYPH
en-wikipedia-org-4107	238	18	methyltransferase	methyltransferase	NN
en-wikipedia-org-4107	238	19	,	,	,
en-wikipedia-org-4107	238	20	the	the	DT
en-wikipedia-org-4107	238	21	same	same	JJ
en-wikipedia-org-4107	238	22	enzyme	enzyme	NNS
en-wikipedia-org-4107	238	23	that	that	WDT
en-wikipedia-org-4107	238	24	metabolizes	metabolize	VBZ
en-wikipedia-org-4107	238	25	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	238	26	into	into	IN
en-wikipedia-org-4107	238	27	epinephrine	epinephrine	NN
en-wikipedia-org-4107	238	28	.	.	.
en-wikipedia-org-4107	239	1	[	[	-LRB-
en-wikipedia-org-4107	239	2	46][197	46][197	NNP
en-wikipedia-org-4107	239	3	]	]	-RRB-
en-wikipedia-org-4107	239	4	Like	like	IN
en-wikipedia-org-4107	239	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	239	6	,	,	,
en-wikipedia-org-4107	239	7	both	both	DT
en-wikipedia-org-4107	239	8	phenethylamine	phenethylamine	NN
en-wikipedia-org-4107	239	9	and	and	CC
en-wikipedia-org-4107	239	10	N	N	NNP
en-wikipedia-org-4107	239	11	-	-	HYPH
en-wikipedia-org-4107	239	12	methylphenethylamine	methylphenethylamine	NN
en-wikipedia-org-4107	239	13	regulate	regulate	VBP
en-wikipedia-org-4107	239	14	monoamine	monoamine	NN
en-wikipedia-org-4107	239	15	neurotransmission	neurotransmission	NN
en-wikipedia-org-4107	239	16	via	via	IN
en-wikipedia-org-4107	239	17	TAAR1;[37][196][197	TAAR1;[37][196][197	NNP
en-wikipedia-org-4107	239	18	]	]	-RRB-
en-wikipedia-org-4107	239	19	unlike	unlike	IN
en-wikipedia-org-4107	239	20	amphetamine	amphetamine	NN
en-wikipedia-org-4107	239	21	,	,	,
en-wikipedia-org-4107	239	22	both	both	DT
en-wikipedia-org-4107	239	23	of	of	IN
en-wikipedia-org-4107	239	24	these	these	DT
en-wikipedia-org-4107	239	25	substances	substance	NNS
en-wikipedia-org-4107	239	26	are	be	VBP
en-wikipedia-org-4107	239	27	broken	break	VBN
en-wikipedia-org-4107	239	28	down	down	RP
en-wikipedia-org-4107	239	29	by	by	IN
en-wikipedia-org-4107	239	30	monoamine	monoamine	NN
en-wikipedia-org-4107	239	31	oxidase	oxidase	NNP
en-wikipedia-org-4107	239	32	B	B	NNP
en-wikipedia-org-4107	239	33	,	,	,
en-wikipedia-org-4107	239	34	and	and	CC
en-wikipedia-org-4107	239	35	therefore	therefore	RB
en-wikipedia-org-4107	239	36	have	have	VBP
en-wikipedia-org-4107	239	37	a	a	DT
en-wikipedia-org-4107	239	38	shorter	short	JJR
en-wikipedia-org-4107	239	39	half	half	JJ
en-wikipedia-org-4107	239	40	-	-	HYPH
en-wikipedia-org-4107	239	41	life	life	NN
en-wikipedia-org-4107	239	42	than	than	IN
en-wikipedia-org-4107	239	43	amphetamine	amphetamine	NN
en-wikipedia-org-4107	239	44	.	.	.
en-wikipedia-org-4107	240	1	[	[	-LRB-
en-wikipedia-org-4107	240	2	46][197	46][197	CD
en-wikipedia-org-4107	240	3	]	]	-RRB-
en-wikipedia-org-4107	240	4	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	240	5	Racemic	Racemic	NNP
en-wikipedia-org-4107	240	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	240	7	Levoamphetamine	Levoamphetamine	NNP
en-wikipedia-org-4107	240	8	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	240	9	The	the	DT
en-wikipedia-org-4107	240	10	skeletal	skeletal	JJ
en-wikipedia-org-4107	240	11	structures	structure	NNS
en-wikipedia-org-4107	240	12	of	of	IN
en-wikipedia-org-4107	240	13	L	l	NN
en-wikipedia-org-4107	240	14	-	-	HYPH
en-wikipedia-org-4107	240	15	amph	amph	NNP
en-wikipedia-org-4107	240	16	and	and	CC
en-wikipedia-org-4107	240	17	D	D	NNP
en-wikipedia-org-4107	240	18	-	-	HYPH
en-wikipedia-org-4107	240	19	amph	amph	NN
en-wikipedia-org-4107	240	20	A	a	DT
en-wikipedia-org-4107	240	21	vial	vial	NN
en-wikipedia-org-4107	240	22	of	of	IN
en-wikipedia-org-4107	240	23	the	the	DT
en-wikipedia-org-4107	240	24	colorless	colorless	JJ
en-wikipedia-org-4107	240	25	amphetamine	amphetamine	VB
en-wikipedia-org-4107	240	26	free	free	JJ
en-wikipedia-org-4107	240	27	base	base	NN
en-wikipedia-org-4107	240	28	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	240	29	hydrochloride	hydrochloride	NN
en-wikipedia-org-4107	240	30	(	(	-LRB-
en-wikipedia-org-4107	240	31	left	leave	VBN
en-wikipedia-org-4107	240	32	bowl	bowl	NN
en-wikipedia-org-4107	240	33	)	)	-RRB-
en-wikipedia-org-4107	240	34	Phenyl-2-nitropropene	phenyl-2-nitropropene	NN
en-wikipedia-org-4107	240	35	(	(	-LRB-
en-wikipedia-org-4107	240	36	right	right	JJ
en-wikipedia-org-4107	240	37	cups	cup	NNS
en-wikipedia-org-4107	240	38	)	)	-RRB-
en-wikipedia-org-4107	240	39	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	240	40	is	be	VBZ
en-wikipedia-org-4107	240	41	a	a	DT
en-wikipedia-org-4107	240	42	methyl	methyl	NN
en-wikipedia-org-4107	240	43	homolog	homolog	NN
en-wikipedia-org-4107	240	44	of	of	IN
en-wikipedia-org-4107	240	45	the	the	DT
en-wikipedia-org-4107	240	46	mammalian	mammalian	NNP
en-wikipedia-org-4107	240	47	neurotransmitter	neurotransmitter	NNP
en-wikipedia-org-4107	240	48	phenethylamine	phenethylamine	NN
en-wikipedia-org-4107	240	49	with	with	IN
en-wikipedia-org-4107	240	50	the	the	DT
en-wikipedia-org-4107	240	51	chemical	chemical	NN
en-wikipedia-org-4107	240	52	formula	formula	NN
en-wikipedia-org-4107	240	53	C9H13N.	c9h13n.	NN
en-wikipedia-org-4107	241	1	The	the	DT
en-wikipedia-org-4107	241	2	carbon	carbon	NN
en-wikipedia-org-4107	241	3	atom	atom	NN
en-wikipedia-org-4107	241	4	adjacent	adjacent	JJ
en-wikipedia-org-4107	241	5	to	to	IN
en-wikipedia-org-4107	241	6	the	the	DT
en-wikipedia-org-4107	241	7	primary	primary	JJ
en-wikipedia-org-4107	241	8	amine	amine	NN
en-wikipedia-org-4107	241	9	is	be	VBZ
en-wikipedia-org-4107	241	10	a	a	DT
en-wikipedia-org-4107	241	11	stereogenic	stereogenic	JJ
en-wikipedia-org-4107	241	12	center	center	NN
en-wikipedia-org-4107	241	13	,	,	,
en-wikipedia-org-4107	241	14	and	and	CC
en-wikipedia-org-4107	241	15	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	241	16	is	be	VBZ
en-wikipedia-org-4107	241	17	composed	compose	VBN
en-wikipedia-org-4107	241	18	of	of	IN
en-wikipedia-org-4107	241	19	a	a	DT
en-wikipedia-org-4107	241	20	racemic	racemic	JJ
en-wikipedia-org-4107	241	21	1:1	1:1	NNS
en-wikipedia-org-4107	241	22	mixture	mixture	NN
en-wikipedia-org-4107	241	23	of	of	IN
en-wikipedia-org-4107	241	24	two	two	CD
en-wikipedia-org-4107	241	25	enantiomers	enantiomer	NNS
en-wikipedia-org-4107	241	26	.	.	.
en-wikipedia-org-4107	242	1	[	[	-LRB-
en-wikipedia-org-4107	242	2	23	23	CD
en-wikipedia-org-4107	242	3	]	]	-RRB-
en-wikipedia-org-4107	242	4	This	this	DT
en-wikipedia-org-4107	242	5	racemic	racemic	NN
en-wikipedia-org-4107	242	6	mixture	mixture	NN
en-wikipedia-org-4107	242	7	can	can	MD
en-wikipedia-org-4107	242	8	be	be	VB
en-wikipedia-org-4107	242	9	separated	separate	VBN
en-wikipedia-org-4107	242	10	into	into	IN
en-wikipedia-org-4107	242	11	its	-PRON-	PRP$
en-wikipedia-org-4107	242	12	optical	optical	JJ
en-wikipedia-org-4107	242	13	isomers:[note	isomers:[note	CD
en-wikipedia-org-4107	242	14	19	19	CD
en-wikipedia-org-4107	242	15	]	]	-RRB-
en-wikipedia-org-4107	242	16	levoamphetamine	levoamphetamine	NN
en-wikipedia-org-4107	242	17	and	and	CC
en-wikipedia-org-4107	242	18	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	242	19	.	.	.
en-wikipedia-org-4107	243	1	[	[	-LRB-
en-wikipedia-org-4107	243	2	23	23	CD
en-wikipedia-org-4107	243	3	]	]	-RRB-
en-wikipedia-org-4107	243	4	At	at	IN
en-wikipedia-org-4107	243	5	room	room	NN
en-wikipedia-org-4107	243	6	temperature	temperature	NN
en-wikipedia-org-4107	243	7	,	,	,
en-wikipedia-org-4107	243	8	the	the	DT
en-wikipedia-org-4107	243	9	pure	pure	JJ
en-wikipedia-org-4107	243	10	free	free	JJ
en-wikipedia-org-4107	243	11	base	base	NN
en-wikipedia-org-4107	243	12	of	of	IN
en-wikipedia-org-4107	243	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	243	14	is	be	VBZ
en-wikipedia-org-4107	243	15	a	a	DT
en-wikipedia-org-4107	243	16	mobile	mobile	JJ
en-wikipedia-org-4107	243	17	,	,	,
en-wikipedia-org-4107	243	18	colorless	colorless	JJ
en-wikipedia-org-4107	243	19	,	,	,
en-wikipedia-org-4107	243	20	and	and	CC
en-wikipedia-org-4107	243	21	volatile	volatile	JJ
en-wikipedia-org-4107	243	22	liquid	liquid	NN
en-wikipedia-org-4107	243	23	with	with	IN
en-wikipedia-org-4107	243	24	a	a	DT
en-wikipedia-org-4107	243	25	characteristically	characteristically	RB
en-wikipedia-org-4107	243	26	strong	strong	JJ
en-wikipedia-org-4107	243	27	amine	amine	NN
en-wikipedia-org-4107	243	28	odor	odor	NNP
en-wikipedia-org-4107	243	29	,	,	,
en-wikipedia-org-4107	243	30	and	and	CC
en-wikipedia-org-4107	243	31	acrid	acrid	NNP
en-wikipedia-org-4107	243	32	,	,	,
en-wikipedia-org-4107	243	33	burning	burn	VBG
en-wikipedia-org-4107	243	34	taste	taste	NN
en-wikipedia-org-4107	243	35	.	.	.
en-wikipedia-org-4107	244	1	[	[	-LRB-
en-wikipedia-org-4107	244	2	21	21	CD
en-wikipedia-org-4107	244	3	]	]	-RRB-
en-wikipedia-org-4107	244	4	Frequently	frequently	RB
en-wikipedia-org-4107	244	5	prepared	prepare	VBN
en-wikipedia-org-4107	244	6	solid	solid	JJ
en-wikipedia-org-4107	244	7	salts	salt	NNS
en-wikipedia-org-4107	244	8	of	of	IN
en-wikipedia-org-4107	244	9	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	244	10	include	include	VBP
en-wikipedia-org-4107	244	11	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	244	12	adipate,[198	adipate,[198	NNP
en-wikipedia-org-4107	244	13	]	]	-RRB-
en-wikipedia-org-4107	244	14	aspartate,[28	aspartate,[28	NNP
en-wikipedia-org-4107	244	15	]	]	-RRB-
en-wikipedia-org-4107	244	16	hydrochloride,[199	hydrochloride,[199	NNP
en-wikipedia-org-4107	244	17	]	]	-RRB-
en-wikipedia-org-4107	244	18	phosphate,[200	phosphate,[200	NNP
en-wikipedia-org-4107	244	19	]	]	-RRB-
en-wikipedia-org-4107	244	20	saccharate,[28	saccharate,[28	NNP
en-wikipedia-org-4107	244	21	]	]	-RRB-
en-wikipedia-org-4107	244	22	sulfate,[28	sulfate,[28	CD
en-wikipedia-org-4107	244	23	]	]	-RRB-
en-wikipedia-org-4107	244	24	and	and	CC
en-wikipedia-org-4107	244	25	tannate	tannate	NN
en-wikipedia-org-4107	244	26	.	.	.
en-wikipedia-org-4107	245	1	[	[	-LRB-
en-wikipedia-org-4107	245	2	201	201	CD
en-wikipedia-org-4107	245	3	]	]	-RRB-
en-wikipedia-org-4107	245	4	Dextroamphetamine	dextroamphetamine	JJ
en-wikipedia-org-4107	245	5	sulfate	sulfate	NN
en-wikipedia-org-4107	245	6	is	be	VBZ
en-wikipedia-org-4107	245	7	the	the	DT
en-wikipedia-org-4107	245	8	most	most	RBS
en-wikipedia-org-4107	245	9	common	common	JJ
en-wikipedia-org-4107	245	10	enantiopure	enantiopure	NN
en-wikipedia-org-4107	245	11	salt	salt	NN
en-wikipedia-org-4107	245	12	.	.	.
en-wikipedia-org-4107	246	1	[	[	-LRB-
en-wikipedia-org-4107	246	2	47	47	CD
en-wikipedia-org-4107	246	3	]	]	-RRB-
en-wikipedia-org-4107	246	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	246	5	is	be	VBZ
en-wikipedia-org-4107	246	6	also	also	RB
en-wikipedia-org-4107	246	7	the	the	DT
en-wikipedia-org-4107	246	8	parent	parent	NN
en-wikipedia-org-4107	246	9	compound	compound	NN
en-wikipedia-org-4107	246	10	of	of	IN
en-wikipedia-org-4107	246	11	its	-PRON-	PRP$
en-wikipedia-org-4107	246	12	own	own	JJ
en-wikipedia-org-4107	246	13	structural	structural	JJ
en-wikipedia-org-4107	246	14	class	class	NN
en-wikipedia-org-4107	246	15	,	,	,
en-wikipedia-org-4107	246	16	which	which	WDT
en-wikipedia-org-4107	246	17	includes	include	VBZ
en-wikipedia-org-4107	246	18	a	a	DT
en-wikipedia-org-4107	246	19	number	number	NN
en-wikipedia-org-4107	246	20	of	of	IN
en-wikipedia-org-4107	246	21	psychoactive	psychoactive	JJ
en-wikipedia-org-4107	246	22	derivatives	derivative	NNS
en-wikipedia-org-4107	246	23	.	.	.
en-wikipedia-org-4107	247	1	[	[	-LRB-
en-wikipedia-org-4107	247	2	14][23	14][23	CD
en-wikipedia-org-4107	247	3	]	]	-RRB-
en-wikipedia-org-4107	247	4	In	in	IN
en-wikipedia-org-4107	247	5	organic	organic	JJ
en-wikipedia-org-4107	247	6	chemistry	chemistry	NN
en-wikipedia-org-4107	247	7	,	,	,
en-wikipedia-org-4107	247	8	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	247	9	is	be	VBZ
en-wikipedia-org-4107	247	10	an	an	DT
en-wikipedia-org-4107	247	11	excellent	excellent	JJ
en-wikipedia-org-4107	247	12	chiral	chiral	JJ
en-wikipedia-org-4107	247	13	ligand	ligand	NN
en-wikipedia-org-4107	247	14	for	for	IN
en-wikipedia-org-4107	247	15	the	the	DT
en-wikipedia-org-4107	247	16	stereoselective	stereoselective	JJ
en-wikipedia-org-4107	247	17	synthesis	synthesis	NN
en-wikipedia-org-4107	247	18	of	of	IN
en-wikipedia-org-4107	247	19	1,1'-bi-2-naphthol	1,1'-bi-2-naphthol	CD
en-wikipedia-org-4107	247	20	.	.	.
en-wikipedia-org-4107	248	1	[	[	-LRB-
en-wikipedia-org-4107	248	2	202	202	CD
en-wikipedia-org-4107	248	3	]	]	-RRB-
en-wikipedia-org-4107	248	4	Substituted	substitute	VBN
en-wikipedia-org-4107	248	5	derivatives	derivative	NNS
en-wikipedia-org-4107	248	6	For	for	IN
en-wikipedia-org-4107	248	7	a	a	DT
en-wikipedia-org-4107	248	8	more	more	RBR
en-wikipedia-org-4107	248	9	comprehensive	comprehensive	JJ
en-wikipedia-org-4107	248	10	list	list	NN
en-wikipedia-org-4107	248	11	,	,	,
en-wikipedia-org-4107	248	12	see	see	VB
en-wikipedia-org-4107	248	13	Substituted	substitute	VBN
en-wikipedia-org-4107	248	14	amphetamine	amphetamine	NN
en-wikipedia-org-4107	248	15	.	.	.
en-wikipedia-org-4107	249	1	The	the	DT
en-wikipedia-org-4107	249	2	substituted	substitute	VBN
en-wikipedia-org-4107	249	3	derivatives	derivative	NNS
en-wikipedia-org-4107	249	4	of	of	IN
en-wikipedia-org-4107	249	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	249	6	,	,	,
en-wikipedia-org-4107	249	7	or	or	CC
en-wikipedia-org-4107	249	8	"	"	``
en-wikipedia-org-4107	249	9	substituted	substitute	VBN
en-wikipedia-org-4107	249	10	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	249	11	"	"	''
en-wikipedia-org-4107	249	12	,	,	,
en-wikipedia-org-4107	249	13	are	be	VBP
en-wikipedia-org-4107	249	14	a	a	DT
en-wikipedia-org-4107	249	15	broad	broad	JJ
en-wikipedia-org-4107	249	16	range	range	NN
en-wikipedia-org-4107	249	17	of	of	IN
en-wikipedia-org-4107	249	18	chemicals	chemical	NNS
en-wikipedia-org-4107	249	19	that	that	WDT
en-wikipedia-org-4107	249	20	contain	contain	VBP
en-wikipedia-org-4107	249	21	amphetamine	amphetamine	NN
en-wikipedia-org-4107	249	22	as	as	IN
en-wikipedia-org-4107	249	23	a	a	DT
en-wikipedia-org-4107	249	24	"	"	``
en-wikipedia-org-4107	249	25	backbone";[14][48][203	backbone";[14][48][203	NN
en-wikipedia-org-4107	249	26	]	]	-RRB-
en-wikipedia-org-4107	249	27	specifically	specifically	RB
en-wikipedia-org-4107	249	28	,	,	,
en-wikipedia-org-4107	249	29	this	this	DT
en-wikipedia-org-4107	249	30	chemical	chemical	NN
en-wikipedia-org-4107	249	31	class	class	NN
en-wikipedia-org-4107	249	32	includes	include	VBZ
en-wikipedia-org-4107	249	33	derivative	derivative	JJ
en-wikipedia-org-4107	249	34	compounds	compound	NNS
en-wikipedia-org-4107	249	35	that	that	WDT
en-wikipedia-org-4107	249	36	are	be	VBP
en-wikipedia-org-4107	249	37	formed	form	VBN
en-wikipedia-org-4107	249	38	by	by	IN
en-wikipedia-org-4107	249	39	replacing	replace	VBG
en-wikipedia-org-4107	249	40	one	one	CD
en-wikipedia-org-4107	249	41	or	or	CC
en-wikipedia-org-4107	249	42	more	more	JJR
en-wikipedia-org-4107	249	43	hydrogen	hydrogen	NN
en-wikipedia-org-4107	249	44	atoms	atom	NNS
en-wikipedia-org-4107	249	45	in	in	IN
en-wikipedia-org-4107	249	46	the	the	DT
en-wikipedia-org-4107	249	47	amphetamine	amphetamine	NN
en-wikipedia-org-4107	249	48	core	core	NN
en-wikipedia-org-4107	249	49	structure	structure	NN
en-wikipedia-org-4107	249	50	with	with	IN
en-wikipedia-org-4107	249	51	substituents	substituent	NNS
en-wikipedia-org-4107	249	52	.	.	.
en-wikipedia-org-4107	250	1	[	[	-LRB-
en-wikipedia-org-4107	250	2	14][48][204	14][48][204	CD
en-wikipedia-org-4107	250	3	]	]	-RRB-
en-wikipedia-org-4107	250	4	The	the	DT
en-wikipedia-org-4107	250	5	class	class	NN
en-wikipedia-org-4107	250	6	includes	include	VBZ
en-wikipedia-org-4107	250	7	amphetamine	amphetamine	VBP
en-wikipedia-org-4107	250	8	itself	-PRON-	PRP
en-wikipedia-org-4107	250	9	,	,	,
en-wikipedia-org-4107	250	10	stimulants	stimulant	NNS
en-wikipedia-org-4107	250	11	like	like	IN
en-wikipedia-org-4107	250	12	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	250	13	,	,	,
en-wikipedia-org-4107	250	14	serotonergic	serotonergic	JJ
en-wikipedia-org-4107	250	15	empathogens	empathogen	NNS
en-wikipedia-org-4107	250	16	like	like	IN
en-wikipedia-org-4107	250	17	MDMA	mdma	NN
en-wikipedia-org-4107	250	18	,	,	,
en-wikipedia-org-4107	250	19	and	and	CC
en-wikipedia-org-4107	250	20	decongestants	decongestant	VBZ
en-wikipedia-org-4107	250	21	like	like	IN
en-wikipedia-org-4107	250	22	ephedrine	ephedrine	NN
en-wikipedia-org-4107	250	23	,	,	,
en-wikipedia-org-4107	250	24	among	among	IN
en-wikipedia-org-4107	250	25	other	other	JJ
en-wikipedia-org-4107	250	26	subgroups	subgroup	NNS
en-wikipedia-org-4107	250	27	.	.	.
en-wikipedia-org-4107	251	1	[	[	-LRB-
en-wikipedia-org-4107	251	2	14][48][203	14][48][203	CD
en-wikipedia-org-4107	251	3	]	]	-RRB-
en-wikipedia-org-4107	251	4	Synthesis	Synthesis	NNP
en-wikipedia-org-4107	251	5	Further	further	JJ
en-wikipedia-org-4107	251	6	information	information	NN
en-wikipedia-org-4107	251	7	on	on	IN
en-wikipedia-org-4107	251	8	illicit	illicit	JJ
en-wikipedia-org-4107	251	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	251	10	synthesis	synthesis	NN
en-wikipedia-org-4107	251	11	:	:	:
en-wikipedia-org-4107	251	12	History	history	NN
en-wikipedia-org-4107	251	13	and	and	CC
en-wikipedia-org-4107	251	14	culture	culture	NN
en-wikipedia-org-4107	251	15	of	of	IN
en-wikipedia-org-4107	251	16	substituted	substitute	VBN
en-wikipedia-org-4107	251	17	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	251	18	§	§	-LRB-
en-wikipedia-org-4107	251	19	 	  	_SP
en-wikipedia-org-4107	251	20	Illegal	illegal	JJ
en-wikipedia-org-4107	251	21	synthesis	synthesis	NN
en-wikipedia-org-4107	251	22	Since	since	IN
en-wikipedia-org-4107	251	23	the	the	DT
en-wikipedia-org-4107	251	24	first	first	JJ
en-wikipedia-org-4107	251	25	preparation	preparation	NN
en-wikipedia-org-4107	251	26	was	be	VBD
en-wikipedia-org-4107	251	27	reported	report	VBN
en-wikipedia-org-4107	251	28	in	in	IN
en-wikipedia-org-4107	251	29	1887,[205	1887,[205	CD
en-wikipedia-org-4107	251	30	]	]	-RRB-
en-wikipedia-org-4107	251	31	numerous	numerous	JJ
en-wikipedia-org-4107	251	32	synthetic	synthetic	JJ
en-wikipedia-org-4107	251	33	routes	route	NNS
en-wikipedia-org-4107	251	34	to	to	TO
en-wikipedia-org-4107	251	35	amphetamine	amphetamine	VB
en-wikipedia-org-4107	251	36	have	have	VBP
en-wikipedia-org-4107	251	37	been	be	VBN
en-wikipedia-org-4107	251	38	developed	develop	VBN
en-wikipedia-org-4107	251	39	.	.	.
en-wikipedia-org-4107	252	1	[	[	-LRB-
en-wikipedia-org-4107	252	2	206][207	206][207	LS
en-wikipedia-org-4107	252	3	]	]	-RRB-
en-wikipedia-org-4107	252	4	The	the	DT
en-wikipedia-org-4107	252	5	most	most	RBS
en-wikipedia-org-4107	252	6	common	common	JJ
en-wikipedia-org-4107	252	7	route	route	NN
en-wikipedia-org-4107	252	8	of	of	IN
en-wikipedia-org-4107	252	9	both	both	CC
en-wikipedia-org-4107	252	10	legal	legal	JJ
en-wikipedia-org-4107	252	11	and	and	CC
en-wikipedia-org-4107	252	12	illicit	illicit	JJ
en-wikipedia-org-4107	252	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	252	14	synthesis	synthesis	NN
en-wikipedia-org-4107	252	15	employs	employ	VBZ
en-wikipedia-org-4107	252	16	a	a	DT
en-wikipedia-org-4107	252	17	non	non	JJ
en-wikipedia-org-4107	252	18	-	-	JJ
en-wikipedia-org-4107	252	19	metal	metal	JJ
en-wikipedia-org-4107	252	20	reduction	reduction	NN
en-wikipedia-org-4107	252	21	known	know	VBN
en-wikipedia-org-4107	252	22	as	as	IN
en-wikipedia-org-4107	252	23	the	the	DT
en-wikipedia-org-4107	252	24	Leuckart	Leuckart	NNP
en-wikipedia-org-4107	252	25	reaction	reaction	NN
en-wikipedia-org-4107	252	26	(	(	-LRB-
en-wikipedia-org-4107	252	27	method	method	NN
en-wikipedia-org-4107	252	28	 	  	_SP
en-wikipedia-org-4107	252	29	1	1	CD
en-wikipedia-org-4107	252	30	)	)	-RRB-
en-wikipedia-org-4107	252	31	.	.	.
en-wikipedia-org-4107	253	1	[	[	-LRB-
en-wikipedia-org-4107	253	2	47][208	47][208	NNS
en-wikipedia-org-4107	253	3	]	]	-RRB-
en-wikipedia-org-4107	253	4	In	in	IN
en-wikipedia-org-4107	253	5	the	the	DT
en-wikipedia-org-4107	253	6	first	first	JJ
en-wikipedia-org-4107	253	7	step	step	NN
en-wikipedia-org-4107	253	8	,	,	,
en-wikipedia-org-4107	253	9	a	a	DT
en-wikipedia-org-4107	253	10	reaction	reaction	NN
en-wikipedia-org-4107	253	11	between	between	IN
en-wikipedia-org-4107	253	12	phenylacetone	phenylacetone	NN
en-wikipedia-org-4107	253	13	and	and	CC
en-wikipedia-org-4107	253	14	formamide	formamide	NN
en-wikipedia-org-4107	253	15	,	,	,
en-wikipedia-org-4107	253	16	either	either	CC
en-wikipedia-org-4107	253	17	using	use	VBG
en-wikipedia-org-4107	253	18	additional	additional	JJ
en-wikipedia-org-4107	253	19	formic	formic	JJ
en-wikipedia-org-4107	253	20	acid	acid	NN
en-wikipedia-org-4107	253	21	or	or	CC
en-wikipedia-org-4107	253	22	formamide	formamide	VB
en-wikipedia-org-4107	253	23	itself	-PRON-	PRP
en-wikipedia-org-4107	253	24	as	as	IN
en-wikipedia-org-4107	253	25	a	a	DT
en-wikipedia-org-4107	253	26	reducing	reduce	VBG
en-wikipedia-org-4107	253	27	agent	agent	NN
en-wikipedia-org-4107	253	28	,	,	,
en-wikipedia-org-4107	253	29	yields	yield	NNS
en-wikipedia-org-4107	253	30	N	n	NN
en-wikipedia-org-4107	253	31	-	-	HYPH
en-wikipedia-org-4107	253	32	formylamphetamine	formylamphetamine	NN
en-wikipedia-org-4107	253	33	.	.	.
en-wikipedia-org-4107	254	1	This	this	DT
en-wikipedia-org-4107	254	2	intermediate	intermediate	NN
en-wikipedia-org-4107	254	3	is	be	VBZ
en-wikipedia-org-4107	254	4	then	then	RB
en-wikipedia-org-4107	254	5	hydrolyzed	hydrolyze	VBN
en-wikipedia-org-4107	254	6	using	use	VBG
en-wikipedia-org-4107	254	7	hydrochloric	hydrochloric	JJ
en-wikipedia-org-4107	254	8	acid	acid	NN
en-wikipedia-org-4107	254	9	,	,	,
en-wikipedia-org-4107	254	10	and	and	CC
en-wikipedia-org-4107	254	11	subsequently	subsequently	RB
en-wikipedia-org-4107	254	12	basified	basified	JJ
en-wikipedia-org-4107	254	13	,	,	,
en-wikipedia-org-4107	254	14	extracted	extract	VBN
en-wikipedia-org-4107	254	15	with	with	IN
en-wikipedia-org-4107	254	16	organic	organic	JJ
en-wikipedia-org-4107	254	17	solvent	solvent	NN
en-wikipedia-org-4107	254	18	,	,	,
en-wikipedia-org-4107	254	19	concentrated	concentrate	VBD
en-wikipedia-org-4107	254	20	,	,	,
en-wikipedia-org-4107	254	21	and	and	CC
en-wikipedia-org-4107	254	22	distilled	distil	VBD
en-wikipedia-org-4107	254	23	to	to	TO
en-wikipedia-org-4107	254	24	yield	yield	VB
en-wikipedia-org-4107	254	25	the	the	DT
en-wikipedia-org-4107	254	26	free	free	JJ
en-wikipedia-org-4107	254	27	base	base	NN
en-wikipedia-org-4107	254	28	.	.	.
en-wikipedia-org-4107	255	1	The	the	DT
en-wikipedia-org-4107	255	2	free	free	JJ
en-wikipedia-org-4107	255	3	base	base	NN
en-wikipedia-org-4107	255	4	is	be	VBZ
en-wikipedia-org-4107	255	5	then	then	RB
en-wikipedia-org-4107	255	6	dissolved	dissolve	VBN
en-wikipedia-org-4107	255	7	in	in	IN
en-wikipedia-org-4107	255	8	an	an	DT
en-wikipedia-org-4107	255	9	organic	organic	JJ
en-wikipedia-org-4107	255	10	solvent	solvent	NN
en-wikipedia-org-4107	255	11	,	,	,
en-wikipedia-org-4107	255	12	sulfuric	sulfuric	NN
en-wikipedia-org-4107	255	13	acid	acid	NN
en-wikipedia-org-4107	255	14	added	add	VBD
en-wikipedia-org-4107	255	15	,	,	,
en-wikipedia-org-4107	255	16	and	and	CC
en-wikipedia-org-4107	255	17	amphetamine	amphetamine	VB
en-wikipedia-org-4107	255	18	precipitates	precipitate	VBZ
en-wikipedia-org-4107	255	19	out	out	RP
en-wikipedia-org-4107	255	20	as	as	IN
en-wikipedia-org-4107	255	21	the	the	DT
en-wikipedia-org-4107	255	22	sulfate	sulfate	NN
en-wikipedia-org-4107	255	23	salt	salt	NN
en-wikipedia-org-4107	255	24	.	.	.
en-wikipedia-org-4107	256	1	[	[	-LRB-
en-wikipedia-org-4107	256	2	208][209	208][209	LS
en-wikipedia-org-4107	256	3	]	]	-RRB-
en-wikipedia-org-4107	256	4	A	a	DT
en-wikipedia-org-4107	256	5	number	number	NN
en-wikipedia-org-4107	256	6	of	of	IN
en-wikipedia-org-4107	256	7	chiral	chiral	JJ
en-wikipedia-org-4107	256	8	resolutions	resolution	NNS
en-wikipedia-org-4107	256	9	have	have	VBP
en-wikipedia-org-4107	256	10	been	be	VBN
en-wikipedia-org-4107	256	11	developed	develop	VBN
en-wikipedia-org-4107	256	12	to	to	TO
en-wikipedia-org-4107	256	13	separate	separate	VB
en-wikipedia-org-4107	256	14	the	the	DT
en-wikipedia-org-4107	256	15	two	two	CD
en-wikipedia-org-4107	256	16	enantiomers	enantiomer	NNS
en-wikipedia-org-4107	256	17	of	of	IN
en-wikipedia-org-4107	256	18	amphetamine	amphetamine	NN
en-wikipedia-org-4107	256	19	.	.	.
en-wikipedia-org-4107	257	1	[	[	-LRB-
en-wikipedia-org-4107	257	2	206	206	CD
en-wikipedia-org-4107	257	3	]	]	-RRB-
en-wikipedia-org-4107	257	4	For	for	IN
en-wikipedia-org-4107	257	5	example	example	NN
en-wikipedia-org-4107	257	6	,	,	,
en-wikipedia-org-4107	257	7	racemic	racemic	NN
en-wikipedia-org-4107	257	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	257	9	can	can	MD
en-wikipedia-org-4107	257	10	be	be	VB
en-wikipedia-org-4107	257	11	treated	treat	VBN
en-wikipedia-org-4107	257	12	with	with	IN
en-wikipedia-org-4107	257	13	d	d	NN
en-wikipedia-org-4107	257	14	-	-	HYPH
en-wikipedia-org-4107	257	15	tartaric	tartaric	NN
en-wikipedia-org-4107	257	16	acid	acid	NN
en-wikipedia-org-4107	257	17	to	to	TO
en-wikipedia-org-4107	257	18	form	form	VB
en-wikipedia-org-4107	257	19	a	a	DT
en-wikipedia-org-4107	257	20	diastereoisomeric	diastereoisomeric	JJ
en-wikipedia-org-4107	257	21	salt	salt	NN
en-wikipedia-org-4107	257	22	which	which	WDT
en-wikipedia-org-4107	257	23	is	be	VBZ
en-wikipedia-org-4107	257	24	fractionally	fractionally	RB
en-wikipedia-org-4107	257	25	crystallized	crystallize	VBN
en-wikipedia-org-4107	257	26	to	to	TO
en-wikipedia-org-4107	257	27	yield	yield	VB
en-wikipedia-org-4107	257	28	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	257	29	.	.	.
en-wikipedia-org-4107	258	1	[	[	-LRB-
en-wikipedia-org-4107	258	2	210	210	CD
en-wikipedia-org-4107	258	3	]	]	-RRB-
en-wikipedia-org-4107	258	4	Chiral	chiral	JJ
en-wikipedia-org-4107	258	5	resolution	resolution	NN
en-wikipedia-org-4107	258	6	remains	remain	VBZ
en-wikipedia-org-4107	258	7	the	the	DT
en-wikipedia-org-4107	258	8	most	most	RBS
en-wikipedia-org-4107	258	9	economical	economical	JJ
en-wikipedia-org-4107	258	10	method	method	NN
en-wikipedia-org-4107	258	11	for	for	IN
en-wikipedia-org-4107	258	12	obtaining	obtain	VBG
en-wikipedia-org-4107	258	13	optically	optically	RB
en-wikipedia-org-4107	258	14	pure	pure	JJ
en-wikipedia-org-4107	258	15	amphetamine	amphetamine	NN
en-wikipedia-org-4107	258	16	on	on	IN
en-wikipedia-org-4107	258	17	a	a	DT
en-wikipedia-org-4107	258	18	large	large	JJ
en-wikipedia-org-4107	258	19	scale	scale	NN
en-wikipedia-org-4107	258	20	.	.	.
en-wikipedia-org-4107	259	1	[	[	-LRB-
en-wikipedia-org-4107	259	2	211	211	CD
en-wikipedia-org-4107	259	3	]	]	-RRB-
en-wikipedia-org-4107	259	4	In	in	IN
en-wikipedia-org-4107	259	5	addition	addition	NN
en-wikipedia-org-4107	259	6	,	,	,
en-wikipedia-org-4107	259	7	several	several	JJ
en-wikipedia-org-4107	259	8	enantioselective	enantioselective	JJ
en-wikipedia-org-4107	259	9	syntheses	synthesis	NNS
en-wikipedia-org-4107	259	10	of	of	IN
en-wikipedia-org-4107	259	11	amphetamine	amphetamine	NN
en-wikipedia-org-4107	259	12	have	have	VBP
en-wikipedia-org-4107	259	13	been	be	VBN
en-wikipedia-org-4107	259	14	developed	develop	VBN
en-wikipedia-org-4107	259	15	.	.	.
en-wikipedia-org-4107	260	1	In	in	IN
en-wikipedia-org-4107	260	2	one	one	CD
en-wikipedia-org-4107	260	3	example	example	NN
en-wikipedia-org-4107	260	4	,	,	,
en-wikipedia-org-4107	260	5	optically	optically	RB
en-wikipedia-org-4107	260	6	pure	pure	JJ
en-wikipedia-org-4107	260	7	(	(	-LRB-
en-wikipedia-org-4107	260	8	R)-1-phenyl	r)-1-phenyl	NN
en-wikipedia-org-4107	260	9	-	-	HYPH
en-wikipedia-org-4107	260	10	ethanamine	ethanamine	NNP
en-wikipedia-org-4107	260	11	is	be	VBZ
en-wikipedia-org-4107	260	12	condensed	condense	VBN
en-wikipedia-org-4107	260	13	with	with	IN
en-wikipedia-org-4107	260	14	phenylacetone	phenylacetone	NN
en-wikipedia-org-4107	260	15	to	to	TO
en-wikipedia-org-4107	260	16	yield	yield	VB
en-wikipedia-org-4107	260	17	a	a	DT
en-wikipedia-org-4107	260	18	chiral	chiral	JJ
en-wikipedia-org-4107	260	19	Schiff	Schiff	NNP
en-wikipedia-org-4107	260	20	base	base	NN
en-wikipedia-org-4107	260	21	.	.	.
en-wikipedia-org-4107	261	1	In	in	IN
en-wikipedia-org-4107	261	2	the	the	DT
en-wikipedia-org-4107	261	3	key	key	JJ
en-wikipedia-org-4107	261	4	step	step	NN
en-wikipedia-org-4107	261	5	,	,	,
en-wikipedia-org-4107	261	6	this	this	DT
en-wikipedia-org-4107	261	7	intermediate	intermediate	NN
en-wikipedia-org-4107	261	8	is	be	VBZ
en-wikipedia-org-4107	261	9	reduced	reduce	VBN
en-wikipedia-org-4107	261	10	by	by	IN
en-wikipedia-org-4107	261	11	catalytic	catalytic	JJ
en-wikipedia-org-4107	261	12	hydrogenation	hydrogenation	NN
en-wikipedia-org-4107	261	13	with	with	IN
en-wikipedia-org-4107	261	14	a	a	DT
en-wikipedia-org-4107	261	15	transfer	transfer	NN
en-wikipedia-org-4107	261	16	of	of	IN
en-wikipedia-org-4107	261	17	chirality	chirality	NN
en-wikipedia-org-4107	261	18	to	to	IN
en-wikipedia-org-4107	261	19	the	the	DT
en-wikipedia-org-4107	261	20	carbon	carbon	NN
en-wikipedia-org-4107	261	21	atom	atom	NN
en-wikipedia-org-4107	261	22	alpha	alpha	NN
en-wikipedia-org-4107	261	23	to	to	IN
en-wikipedia-org-4107	261	24	the	the	DT
en-wikipedia-org-4107	261	25	amino	amino	JJ
en-wikipedia-org-4107	261	26	group	group	NN
en-wikipedia-org-4107	261	27	.	.	.
en-wikipedia-org-4107	262	1	Cleavage	cleavage	NN
en-wikipedia-org-4107	262	2	of	of	IN
en-wikipedia-org-4107	262	3	the	the	DT
en-wikipedia-org-4107	262	4	benzylic	benzylic	JJ
en-wikipedia-org-4107	262	5	amine	amine	NNP
en-wikipedia-org-4107	262	6	bond	bond	NN
en-wikipedia-org-4107	262	7	by	by	IN
en-wikipedia-org-4107	262	8	hydrogenation	hydrogenation	NN
en-wikipedia-org-4107	262	9	yields	yield	NNS
en-wikipedia-org-4107	262	10	optically	optically	RB
en-wikipedia-org-4107	262	11	pure	pure	JJ
en-wikipedia-org-4107	262	12	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	262	13	.	.	.
en-wikipedia-org-4107	263	1	[	[	-LRB-
en-wikipedia-org-4107	263	2	211	211	CD
en-wikipedia-org-4107	263	3	]	]	-RRB-
en-wikipedia-org-4107	263	4	A	a	DT
en-wikipedia-org-4107	263	5	large	large	JJ
en-wikipedia-org-4107	263	6	number	number	NN
en-wikipedia-org-4107	263	7	of	of	IN
en-wikipedia-org-4107	263	8	alternative	alternative	JJ
en-wikipedia-org-4107	263	9	synthetic	synthetic	JJ
en-wikipedia-org-4107	263	10	routes	route	NNS
en-wikipedia-org-4107	263	11	to	to	TO
en-wikipedia-org-4107	263	12	amphetamine	amphetamine	VB
en-wikipedia-org-4107	263	13	have	have	VBP
en-wikipedia-org-4107	263	14	been	be	VBN
en-wikipedia-org-4107	263	15	developed	develop	VBN
en-wikipedia-org-4107	263	16	based	base	VBN
en-wikipedia-org-4107	263	17	on	on	IN
en-wikipedia-org-4107	263	18	classic	classic	JJ
en-wikipedia-org-4107	263	19	organic	organic	JJ
en-wikipedia-org-4107	263	20	reactions	reaction	NNS
en-wikipedia-org-4107	263	21	.	.	.
en-wikipedia-org-4107	264	1	[	[	-LRB-
en-wikipedia-org-4107	264	2	206][207	206][207	CD
en-wikipedia-org-4107	264	3	]	]	-RRB-
en-wikipedia-org-4107	264	4	One	one	CD
en-wikipedia-org-4107	264	5	example	example	NN
en-wikipedia-org-4107	264	6	is	be	VBZ
en-wikipedia-org-4107	264	7	the	the	DT
en-wikipedia-org-4107	264	8	Friedel	Friedel	NNP
en-wikipedia-org-4107	264	9	–	–	:
en-wikipedia-org-4107	264	10	Crafts	Crafts	NNP
en-wikipedia-org-4107	264	11	alkylation	alkylation	NN
en-wikipedia-org-4107	264	12	of	of	IN
en-wikipedia-org-4107	264	13	benzene	benzene	NN
en-wikipedia-org-4107	264	14	by	by	IN
en-wikipedia-org-4107	264	15	allyl	allyl	NNP
en-wikipedia-org-4107	264	16	chloride	chloride	NNP
en-wikipedia-org-4107	264	17	to	to	TO
en-wikipedia-org-4107	264	18	yield	yield	VB
en-wikipedia-org-4107	264	19	beta	beta	JJ
en-wikipedia-org-4107	264	20	chloropropylbenzene	chloropropylbenzene	NN
en-wikipedia-org-4107	264	21	which	which	WDT
en-wikipedia-org-4107	264	22	is	be	VBZ
en-wikipedia-org-4107	264	23	then	then	RB
en-wikipedia-org-4107	264	24	reacted	react	VBN
en-wikipedia-org-4107	264	25	with	with	IN
en-wikipedia-org-4107	264	26	ammonia	ammonia	NN
en-wikipedia-org-4107	264	27	to	to	TO
en-wikipedia-org-4107	264	28	produce	produce	VB
en-wikipedia-org-4107	264	29	racemic	racemic	JJ
en-wikipedia-org-4107	264	30	amphetamine	amphetamine	NN
en-wikipedia-org-4107	264	31	(	(	-LRB-
en-wikipedia-org-4107	264	32	method	method	NN
en-wikipedia-org-4107	264	33	 	  	_SP
en-wikipedia-org-4107	264	34	2	2	CD
en-wikipedia-org-4107	264	35	)	)	-RRB-
en-wikipedia-org-4107	264	36	.	.	.
en-wikipedia-org-4107	265	1	[	[	-LRB-
en-wikipedia-org-4107	265	2	212	212	CD
en-wikipedia-org-4107	265	3	]	]	-RRB-
en-wikipedia-org-4107	265	4	Another	another	DT
en-wikipedia-org-4107	265	5	example	example	NN
en-wikipedia-org-4107	265	6	employs	employ	VBZ
en-wikipedia-org-4107	265	7	the	the	DT
en-wikipedia-org-4107	265	8	Ritter	ritter	NN
en-wikipedia-org-4107	265	9	reaction	reaction	NN
en-wikipedia-org-4107	265	10	(	(	-LRB-
en-wikipedia-org-4107	265	11	method	method	NN
en-wikipedia-org-4107	265	12	 	  	_SP
en-wikipedia-org-4107	265	13	3	3	CD
en-wikipedia-org-4107	265	14	)	)	-RRB-
en-wikipedia-org-4107	265	15	.	.	.
en-wikipedia-org-4107	266	1	In	in	IN
en-wikipedia-org-4107	266	2	this	this	DT
en-wikipedia-org-4107	266	3	route	route	NN
en-wikipedia-org-4107	266	4	,	,	,
en-wikipedia-org-4107	266	5	allylbenzene	allylbenzene	NNP
en-wikipedia-org-4107	266	6	is	be	VBZ
en-wikipedia-org-4107	266	7	reacted	react	VBN
en-wikipedia-org-4107	266	8	acetonitrile	acetonitrile	RB
en-wikipedia-org-4107	266	9	in	in	IN
en-wikipedia-org-4107	266	10	sulfuric	sulfuric	NN
en-wikipedia-org-4107	266	11	acid	acid	NN
en-wikipedia-org-4107	266	12	to	to	TO
en-wikipedia-org-4107	266	13	yield	yield	VB
en-wikipedia-org-4107	266	14	an	an	DT
en-wikipedia-org-4107	266	15	organosulfate	organosulfate	NN
en-wikipedia-org-4107	266	16	which	which	WDT
en-wikipedia-org-4107	266	17	in	in	IN
en-wikipedia-org-4107	266	18	turn	turn	NN
en-wikipedia-org-4107	266	19	is	be	VBZ
en-wikipedia-org-4107	266	20	treated	treat	VBN
en-wikipedia-org-4107	266	21	with	with	IN
en-wikipedia-org-4107	266	22	sodium	sodium	NN
en-wikipedia-org-4107	266	23	hydroxide	hydroxide	NN
en-wikipedia-org-4107	266	24	to	to	TO
en-wikipedia-org-4107	266	25	give	give	VB
en-wikipedia-org-4107	266	26	amphetamine	amphetamine	NN
en-wikipedia-org-4107	266	27	via	via	IN
en-wikipedia-org-4107	266	28	an	an	DT
en-wikipedia-org-4107	266	29	acetamide	acetamide	NN
en-wikipedia-org-4107	266	30	intermediate	intermediate	JJ
en-wikipedia-org-4107	266	31	.	.	.
en-wikipedia-org-4107	267	1	[	[	-LRB-
en-wikipedia-org-4107	267	2	213][214	213][214	LS
en-wikipedia-org-4107	267	3	]	]	-RRB-
en-wikipedia-org-4107	267	4	A	a	DT
en-wikipedia-org-4107	267	5	third	third	JJ
en-wikipedia-org-4107	267	6	route	route	NN
en-wikipedia-org-4107	267	7	starts	start	VBZ
en-wikipedia-org-4107	267	8	with	with	IN
en-wikipedia-org-4107	267	9	ethyl	ethyl	NNP
en-wikipedia-org-4107	267	10	3-oxobutanoate	3-oxobutanoate	CD
en-wikipedia-org-4107	267	11	which	which	WDT
en-wikipedia-org-4107	267	12	through	through	IN
en-wikipedia-org-4107	267	13	a	a	DT
en-wikipedia-org-4107	267	14	double	double	JJ
en-wikipedia-org-4107	267	15	alkylation	alkylation	NN
en-wikipedia-org-4107	267	16	with	with	IN
en-wikipedia-org-4107	267	17	methyl	methyl	NN
en-wikipedia-org-4107	267	18	iodide	iodide	NN
en-wikipedia-org-4107	267	19	followed	follow	VBN
en-wikipedia-org-4107	267	20	by	by	IN
en-wikipedia-org-4107	267	21	benzyl	benzyl	NN
en-wikipedia-org-4107	267	22	chloride	chloride	NN
en-wikipedia-org-4107	267	23	can	can	MD
en-wikipedia-org-4107	267	24	be	be	VB
en-wikipedia-org-4107	267	25	converted	convert	VBN
en-wikipedia-org-4107	267	26	into	into	IN
en-wikipedia-org-4107	267	27	2-methyl-3-phenyl	2-methyl-3-phenyl	CD
en-wikipedia-org-4107	267	28	-	-	HYPH
en-wikipedia-org-4107	267	29	propanoic	propanoic	NN
en-wikipedia-org-4107	267	30	acid	acid	NN
en-wikipedia-org-4107	267	31	.	.	.
en-wikipedia-org-4107	268	1	This	this	DT
en-wikipedia-org-4107	268	2	synthetic	synthetic	JJ
en-wikipedia-org-4107	268	3	intermediate	intermediate	NN
en-wikipedia-org-4107	268	4	can	can	MD
en-wikipedia-org-4107	268	5	be	be	VB
en-wikipedia-org-4107	268	6	transformed	transform	VBN
en-wikipedia-org-4107	268	7	into	into	IN
en-wikipedia-org-4107	268	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	268	9	using	use	VBG
en-wikipedia-org-4107	268	10	either	either	CC
en-wikipedia-org-4107	268	11	a	a	DT
en-wikipedia-org-4107	268	12	Hofmann	Hofmann	NNP
en-wikipedia-org-4107	268	13	or	or	CC
en-wikipedia-org-4107	268	14	Curtius	Curtius	NNP
en-wikipedia-org-4107	268	15	rearrangement	rearrangement	NN
en-wikipedia-org-4107	268	16	(	(	-LRB-
en-wikipedia-org-4107	268	17	method	method	NN
en-wikipedia-org-4107	268	18	 	  	_SP
en-wikipedia-org-4107	268	19	4	4	CD
en-wikipedia-org-4107	268	20	)	)	-RRB-
en-wikipedia-org-4107	268	21	.	.	.
en-wikipedia-org-4107	269	1	[	[	-LRB-
en-wikipedia-org-4107	269	2	215	215	CD
en-wikipedia-org-4107	269	3	]	]	-RRB-
en-wikipedia-org-4107	269	4	A	a	DT
en-wikipedia-org-4107	269	5	significant	significant	JJ
en-wikipedia-org-4107	269	6	number	number	NN
en-wikipedia-org-4107	269	7	of	of	IN
en-wikipedia-org-4107	269	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	269	9	syntheses	synthesis	NNS
en-wikipedia-org-4107	269	10	feature	feature	VBP
en-wikipedia-org-4107	269	11	a	a	DT
en-wikipedia-org-4107	269	12	reduction	reduction	NN
en-wikipedia-org-4107	269	13	of	of	IN
en-wikipedia-org-4107	269	14	a	a	DT
en-wikipedia-org-4107	269	15	nitro	nitro	NNP
en-wikipedia-org-4107	269	16	,	,	,
en-wikipedia-org-4107	269	17	imine	imine	NNP
en-wikipedia-org-4107	269	18	,	,	,
en-wikipedia-org-4107	269	19	oxime	oxime	NN
en-wikipedia-org-4107	269	20	,	,	,
en-wikipedia-org-4107	269	21	or	or	CC
en-wikipedia-org-4107	269	22	other	other	JJ
en-wikipedia-org-4107	269	23	nitrogen	nitrogen	NN
en-wikipedia-org-4107	269	24	-	-	HYPH
en-wikipedia-org-4107	269	25	containing	contain	VBG
en-wikipedia-org-4107	269	26	functional	functional	JJ
en-wikipedia-org-4107	269	27	groups	group	NNS
en-wikipedia-org-4107	269	28	.	.	.
en-wikipedia-org-4107	270	1	[	[	-LRB-
en-wikipedia-org-4107	270	2	207	207	CD
en-wikipedia-org-4107	270	3	]	]	-RRB-
en-wikipedia-org-4107	270	4	In	in	IN
en-wikipedia-org-4107	270	5	one	one	CD
en-wikipedia-org-4107	270	6	such	such	JJ
en-wikipedia-org-4107	270	7	example	example	NN
en-wikipedia-org-4107	270	8	,	,	,
en-wikipedia-org-4107	270	9	a	a	DT
en-wikipedia-org-4107	270	10	Knoevenagel	Knoevenagel	NNP
en-wikipedia-org-4107	270	11	condensation	condensation	NN
en-wikipedia-org-4107	270	12	of	of	IN
en-wikipedia-org-4107	270	13	benzaldehyde	benzaldehyde	NNP
en-wikipedia-org-4107	270	14	with	with	IN
en-wikipedia-org-4107	270	15	nitroethane	nitroethane	NN
en-wikipedia-org-4107	270	16	yields	yield	NNS
en-wikipedia-org-4107	270	17	phenyl-2-nitropropene	phenyl-2-nitropropene	NNP
en-wikipedia-org-4107	270	18	.	.	.
en-wikipedia-org-4107	271	1	The	the	DT
en-wikipedia-org-4107	271	2	double	double	JJ
en-wikipedia-org-4107	271	3	bond	bond	NN
en-wikipedia-org-4107	271	4	and	and	CC
en-wikipedia-org-4107	271	5	nitro	nitro	JJ
en-wikipedia-org-4107	271	6	group	group	NN
en-wikipedia-org-4107	271	7	of	of	IN
en-wikipedia-org-4107	271	8	this	this	DT
en-wikipedia-org-4107	271	9	intermediate	intermediate	NN
en-wikipedia-org-4107	271	10	is	be	VBZ
en-wikipedia-org-4107	271	11	reduced	reduce	VBN
en-wikipedia-org-4107	271	12	using	use	VBG
en-wikipedia-org-4107	271	13	either	either	CC
en-wikipedia-org-4107	271	14	catalytic	catalytic	JJ
en-wikipedia-org-4107	271	15	hydrogenation	hydrogenation	NN
en-wikipedia-org-4107	271	16	or	or	CC
en-wikipedia-org-4107	271	17	by	by	IN
en-wikipedia-org-4107	271	18	treatment	treatment	NN
en-wikipedia-org-4107	271	19	with	with	IN
en-wikipedia-org-4107	271	20	lithium	lithium	NN
en-wikipedia-org-4107	271	21	aluminium	aluminium	NN
en-wikipedia-org-4107	271	22	hydride	hydride	NN
en-wikipedia-org-4107	271	23	(	(	-LRB-
en-wikipedia-org-4107	271	24	method	method	NN
en-wikipedia-org-4107	271	25	 	  	_SP
en-wikipedia-org-4107	271	26	5	5	CD
en-wikipedia-org-4107	271	27	)	)	-RRB-
en-wikipedia-org-4107	271	28	.	.	.
en-wikipedia-org-4107	272	1	[	[	-LRB-
en-wikipedia-org-4107	272	2	208][216	208][216	LS
en-wikipedia-org-4107	272	3	]	]	-RRB-
en-wikipedia-org-4107	272	4	Another	another	DT
en-wikipedia-org-4107	272	5	method	method	NN
en-wikipedia-org-4107	272	6	is	be	VBZ
en-wikipedia-org-4107	272	7	the	the	DT
en-wikipedia-org-4107	272	8	reaction	reaction	NN
en-wikipedia-org-4107	272	9	of	of	IN
en-wikipedia-org-4107	272	10	phenylacetone	phenylacetone	NN
en-wikipedia-org-4107	272	11	with	with	IN
en-wikipedia-org-4107	272	12	ammonia	ammonia	NNP
en-wikipedia-org-4107	272	13	,	,	,
en-wikipedia-org-4107	272	14	producing	produce	VBG
en-wikipedia-org-4107	272	15	an	an	DT
en-wikipedia-org-4107	272	16	imine	imine	NN
en-wikipedia-org-4107	272	17	intermediate	intermediate	JJ
en-wikipedia-org-4107	272	18	that	that	WDT
en-wikipedia-org-4107	272	19	is	be	VBZ
en-wikipedia-org-4107	272	20	reduced	reduce	VBN
en-wikipedia-org-4107	272	21	to	to	IN
en-wikipedia-org-4107	272	22	the	the	DT
en-wikipedia-org-4107	272	23	primary	primary	JJ
en-wikipedia-org-4107	272	24	amine	amine	NN
en-wikipedia-org-4107	272	25	using	use	VBG
en-wikipedia-org-4107	272	26	hydrogen	hydrogen	NN
en-wikipedia-org-4107	272	27	over	over	IN
en-wikipedia-org-4107	272	28	a	a	DT
en-wikipedia-org-4107	272	29	palladium	palladium	NN
en-wikipedia-org-4107	272	30	catalyst	catalyst	NN
en-wikipedia-org-4107	272	31	or	or	CC
en-wikipedia-org-4107	272	32	lithium	lithium	NN
en-wikipedia-org-4107	272	33	aluminum	aluminum	NN
en-wikipedia-org-4107	272	34	hydride	hydride	NN
en-wikipedia-org-4107	272	35	(	(	-LRB-
en-wikipedia-org-4107	272	36	method	method	NN
en-wikipedia-org-4107	272	37	 	  	_SP
en-wikipedia-org-4107	272	38	6	6	CD
en-wikipedia-org-4107	272	39	)	)	-RRB-
en-wikipedia-org-4107	272	40	.	.	.
en-wikipedia-org-4107	273	1	[	[	-LRB-
en-wikipedia-org-4107	273	2	208	208	CD
en-wikipedia-org-4107	273	3	]	]	-RRB-
en-wikipedia-org-4107	273	4	Amphetamine	amphetamine	VB
en-wikipedia-org-4107	273	5	synthetic	synthetic	JJ
en-wikipedia-org-4107	273	6	routes	route	NNS
en-wikipedia-org-4107	273	7	Method	Method	NNP
en-wikipedia-org-4107	273	8	 	  	_SP
en-wikipedia-org-4107	273	9	1	1	CD
en-wikipedia-org-4107	273	10	:	:	:
en-wikipedia-org-4107	273	11	Synthesis	synthesis	NN
en-wikipedia-org-4107	273	12	by	by	IN
en-wikipedia-org-4107	273	13	the	the	DT
en-wikipedia-org-4107	273	14	Leuckart	Leuckart	NNP
en-wikipedia-org-4107	273	15	reaction	reaction	NN
en-wikipedia-org-4107	273	16	  	  	_SP
en-wikipedia-org-4107	273	17	Top	Top	NNP
en-wikipedia-org-4107	273	18	:	:	:
en-wikipedia-org-4107	273	19	Chiral	chiral	JJ
en-wikipedia-org-4107	273	20	resolution	resolution	NN
en-wikipedia-org-4107	273	21	of	of	IN
en-wikipedia-org-4107	273	22	amphetamine	amphetamine	NN
en-wikipedia-org-4107	273	23	  	  	_SP
en-wikipedia-org-4107	273	24	Bottom	Bottom	NNP
en-wikipedia-org-4107	273	25	:	:	:
en-wikipedia-org-4107	273	26	Stereoselective	stereoselective	JJ
en-wikipedia-org-4107	273	27	synthesis	synthesis	NN
en-wikipedia-org-4107	273	28	of	of	IN
en-wikipedia-org-4107	273	29	amphetamine	amphetamine	NN
en-wikipedia-org-4107	273	30	  	  	_SP
en-wikipedia-org-4107	273	31	Method	Method	NNP
en-wikipedia-org-4107	273	32	 	  	_SP
en-wikipedia-org-4107	273	33	2	2	CD
en-wikipedia-org-4107	273	34	:	:	:
en-wikipedia-org-4107	273	35	Synthesis	Synthesis	NNP
en-wikipedia-org-4107	273	36	by	by	IN
en-wikipedia-org-4107	273	37	Friedel	Friedel	NNP
en-wikipedia-org-4107	273	38	–	–	:
en-wikipedia-org-4107	273	39	Crafts	Crafts	NNP
en-wikipedia-org-4107	273	40	alkylation	alkylation	NN
en-wikipedia-org-4107	273	41	  	  	_SP
en-wikipedia-org-4107	273	42	Method	Method	NNP
en-wikipedia-org-4107	273	43	 	  	_SP
en-wikipedia-org-4107	273	44	3	3	CD
en-wikipedia-org-4107	273	45	:	:	:
en-wikipedia-org-4107	273	46	Ritter	ritter	NN
en-wikipedia-org-4107	273	47	synthesis	synthesis	NN
en-wikipedia-org-4107	273	48	Method	Method	NNP
en-wikipedia-org-4107	273	49	 	  	_SP
en-wikipedia-org-4107	273	50	4	4	CD
en-wikipedia-org-4107	273	51	:	:	:
en-wikipedia-org-4107	273	52	Synthesis	synthesis	NN
en-wikipedia-org-4107	273	53	via	via	IN
en-wikipedia-org-4107	273	54	Hofmann	Hofmann	NNP
en-wikipedia-org-4107	273	55	and	and	CC
en-wikipedia-org-4107	273	56	Curtius	Curtius	NNP
en-wikipedia-org-4107	273	57	rearrangements	rearrangement	VBZ
en-wikipedia-org-4107	273	58	Method	Method	NNP
en-wikipedia-org-4107	273	59	 	  	_SP
en-wikipedia-org-4107	273	60	5	5	CD
en-wikipedia-org-4107	273	61	:	:	:
en-wikipedia-org-4107	273	62	Synthesis	Synthesis	NNP
en-wikipedia-org-4107	273	63	by	by	IN
en-wikipedia-org-4107	273	64	Knoevenagel	Knoevenagel	NNP
en-wikipedia-org-4107	273	65	condensation	condensation	NN
en-wikipedia-org-4107	273	66	Method	Method	NNP
en-wikipedia-org-4107	273	67	 	  	_SP
en-wikipedia-org-4107	273	68	6	6	CD
en-wikipedia-org-4107	273	69	:	:	:
en-wikipedia-org-4107	273	70	Synthesis	Synthesis	NNP
en-wikipedia-org-4107	273	71	using	use	VBG
en-wikipedia-org-4107	273	72	phenylacetone	phenylacetone	NN
en-wikipedia-org-4107	273	73	and	and	CC
en-wikipedia-org-4107	273	74	ammonia	ammonia	NN
en-wikipedia-org-4107	273	75	Detection	detection	NN
en-wikipedia-org-4107	273	76	in	in	IN
en-wikipedia-org-4107	273	77	body	body	NN
en-wikipedia-org-4107	273	78	fluids	fluid	NNS
en-wikipedia-org-4107	273	79	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	273	80	is	be	VBZ
en-wikipedia-org-4107	273	81	frequently	frequently	RB
en-wikipedia-org-4107	273	82	measured	measure	VBN
en-wikipedia-org-4107	273	83	in	in	IN
en-wikipedia-org-4107	273	84	urine	urine	NN
en-wikipedia-org-4107	273	85	or	or	CC
en-wikipedia-org-4107	273	86	blood	blood	NN
en-wikipedia-org-4107	273	87	as	as	IN
en-wikipedia-org-4107	273	88	part	part	NN
en-wikipedia-org-4107	273	89	of	of	IN
en-wikipedia-org-4107	273	90	a	a	DT
en-wikipedia-org-4107	273	91	drug	drug	NN
en-wikipedia-org-4107	273	92	test	test	NN
en-wikipedia-org-4107	273	93	for	for	IN
en-wikipedia-org-4107	273	94	sports	sport	NNS
en-wikipedia-org-4107	273	95	,	,	,
en-wikipedia-org-4107	273	96	employment	employment	NN
en-wikipedia-org-4107	273	97	,	,	,
en-wikipedia-org-4107	273	98	poisoning	poisoning	NN
en-wikipedia-org-4107	273	99	diagnostics	diagnostic	NNS
en-wikipedia-org-4107	273	100	,	,	,
en-wikipedia-org-4107	273	101	and	and	CC
en-wikipedia-org-4107	273	102	forensics	forensic	NNS
en-wikipedia-org-4107	273	103	.	.	.
en-wikipedia-org-4107	274	1	[	[	-LRB-
en-wikipedia-org-4107	274	2	sources	source	NNS
en-wikipedia-org-4107	274	3	17	17	CD
en-wikipedia-org-4107	274	4	]	]	-RRB-
en-wikipedia-org-4107	274	5	Techniques	technique	NNS
en-wikipedia-org-4107	274	6	such	such	JJ
en-wikipedia-org-4107	274	7	as	as	IN
en-wikipedia-org-4107	274	8	immunoassay	immunoassay	NNP
en-wikipedia-org-4107	274	9	,	,	,
en-wikipedia-org-4107	274	10	which	which	WDT
en-wikipedia-org-4107	274	11	is	be	VBZ
en-wikipedia-org-4107	274	12	the	the	DT
en-wikipedia-org-4107	274	13	most	most	RBS
en-wikipedia-org-4107	274	14	common	common	JJ
en-wikipedia-org-4107	274	15	form	form	NN
en-wikipedia-org-4107	274	16	of	of	IN
en-wikipedia-org-4107	274	17	amphetamine	amphetamine	NN
en-wikipedia-org-4107	274	18	test	test	NN
en-wikipedia-org-4107	274	19	,	,	,
en-wikipedia-org-4107	274	20	may	may	MD
en-wikipedia-org-4107	274	21	cross	cross	VB
en-wikipedia-org-4107	274	22	-	-	JJ
en-wikipedia-org-4107	274	23	react	react	VB
en-wikipedia-org-4107	274	24	with	with	IN
en-wikipedia-org-4107	274	25	a	a	DT
en-wikipedia-org-4107	274	26	number	number	NN
en-wikipedia-org-4107	274	27	of	of	IN
en-wikipedia-org-4107	274	28	sympathomimetic	sympathomimetic	JJ
en-wikipedia-org-4107	274	29	drugs	drug	NNS
en-wikipedia-org-4107	274	30	.	.	.
en-wikipedia-org-4107	275	1	[	[	-LRB-
en-wikipedia-org-4107	275	2	220	220	CD
en-wikipedia-org-4107	275	3	]	]	-RRB-
en-wikipedia-org-4107	275	4	Chromatographic	chromatographic	JJ
en-wikipedia-org-4107	275	5	methods	method	NNS
en-wikipedia-org-4107	275	6	specific	specific	JJ
en-wikipedia-org-4107	275	7	for	for	IN
en-wikipedia-org-4107	275	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	275	9	are	be	VBP
en-wikipedia-org-4107	275	10	employed	employ	VBN
en-wikipedia-org-4107	275	11	to	to	TO
en-wikipedia-org-4107	275	12	prevent	prevent	VB
en-wikipedia-org-4107	275	13	false	false	JJ
en-wikipedia-org-4107	275	14	positive	positive	JJ
en-wikipedia-org-4107	275	15	results	result	NNS
en-wikipedia-org-4107	275	16	.	.	.
en-wikipedia-org-4107	276	1	[	[	-LRB-
en-wikipedia-org-4107	276	2	221	221	CD
en-wikipedia-org-4107	276	3	]	]	-RRB-
en-wikipedia-org-4107	276	4	Chiral	chiral	JJ
en-wikipedia-org-4107	276	5	separation	separation	NN
en-wikipedia-org-4107	276	6	techniques	technique	NNS
en-wikipedia-org-4107	276	7	may	may	MD
en-wikipedia-org-4107	276	8	be	be	VB
en-wikipedia-org-4107	276	9	employed	employ	VBN
en-wikipedia-org-4107	276	10	to	to	TO
en-wikipedia-org-4107	276	11	help	help	VB
en-wikipedia-org-4107	276	12	distinguish	distinguish	VB
en-wikipedia-org-4107	276	13	the	the	DT
en-wikipedia-org-4107	276	14	source	source	NN
en-wikipedia-org-4107	276	15	of	of	IN
en-wikipedia-org-4107	276	16	the	the	DT
en-wikipedia-org-4107	276	17	drug	drug	NN
en-wikipedia-org-4107	276	18	,	,	,
en-wikipedia-org-4107	276	19	whether	whether	IN
en-wikipedia-org-4107	276	20	prescription	prescription	NN
en-wikipedia-org-4107	276	21	amphetamine	amphetamine	NN
en-wikipedia-org-4107	276	22	,	,	,
en-wikipedia-org-4107	276	23	prescription	prescription	NN
en-wikipedia-org-4107	276	24	amphetamine	amphetamine	NN
en-wikipedia-org-4107	276	25	prodrugs	prodrug	NNS
en-wikipedia-org-4107	276	26	,	,	,
en-wikipedia-org-4107	276	27	(	(	-LRB-
en-wikipedia-org-4107	276	28	e.g.	e.g.	RB
en-wikipedia-org-4107	276	29	,	,	,
en-wikipedia-org-4107	276	30	selegiline	selegiline	NN
en-wikipedia-org-4107	276	31	)	)	-RRB-
en-wikipedia-org-4107	276	32	,	,	,
en-wikipedia-org-4107	276	33	over	over	IN
en-wikipedia-org-4107	276	34	-	-	HYPH
en-wikipedia-org-4107	276	35	the	the	DT
en-wikipedia-org-4107	276	36	-	-	HYPH
en-wikipedia-org-4107	276	37	counter	counter	NN
en-wikipedia-org-4107	276	38	drug	drug	NN
en-wikipedia-org-4107	276	39	products	product	NNS
en-wikipedia-org-4107	276	40	that	that	WDT
en-wikipedia-org-4107	276	41	contain	contain	VBP
en-wikipedia-org-4107	276	42	levomethamphetamine,[note	levomethamphetamine,[note	-LRB-
en-wikipedia-org-4107	276	43	20	20	CD
en-wikipedia-org-4107	276	44	]	]	-RRB-
en-wikipedia-org-4107	276	45	or	or	CC
en-wikipedia-org-4107	276	46	illicitly	illicitly	RB
en-wikipedia-org-4107	276	47	obtained	obtain	VBN
en-wikipedia-org-4107	276	48	substituted	substitute	VBN
en-wikipedia-org-4107	276	49	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	276	50	.	.	.
en-wikipedia-org-4107	277	1	[	[	-LRB-
en-wikipedia-org-4107	277	2	221][224][225	221][224][225	CD
en-wikipedia-org-4107	277	3	]	]	-RRB-
en-wikipedia-org-4107	277	4	Several	several	JJ
en-wikipedia-org-4107	277	5	prescription	prescription	NN
en-wikipedia-org-4107	277	6	drugs	drug	NNS
en-wikipedia-org-4107	277	7	produce	produce	VBP
en-wikipedia-org-4107	277	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	277	9	as	as	IN
en-wikipedia-org-4107	277	10	a	a	DT
en-wikipedia-org-4107	277	11	metabolite	metabolite	NN
en-wikipedia-org-4107	277	12	,	,	,
en-wikipedia-org-4107	277	13	including	include	VBG
en-wikipedia-org-4107	277	14	benzphetamine	benzphetamine	NN
en-wikipedia-org-4107	277	15	,	,	,
en-wikipedia-org-4107	277	16	clobenzorex	clobenzorex	NNP
en-wikipedia-org-4107	277	17	,	,	,
en-wikipedia-org-4107	277	18	famprofazone	famprofazone	NNP
en-wikipedia-org-4107	277	19	,	,	,
en-wikipedia-org-4107	277	20	fenproporex	fenproporex	NNP
en-wikipedia-org-4107	277	21	,	,	,
en-wikipedia-org-4107	277	22	lisdexamfetamine	lisdexamfetamine	NNP
en-wikipedia-org-4107	277	23	,	,	,
en-wikipedia-org-4107	277	24	mesocarb	mesocarb	NNP
en-wikipedia-org-4107	277	25	,	,	,
en-wikipedia-org-4107	277	26	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	277	27	,	,	,
en-wikipedia-org-4107	277	28	prenylamine	prenylamine	NNP
en-wikipedia-org-4107	277	29	,	,	,
en-wikipedia-org-4107	277	30	and	and	CC
en-wikipedia-org-4107	277	31	selegiline	selegiline	NNP
en-wikipedia-org-4107	277	32	,	,	,
en-wikipedia-org-4107	277	33	among	among	IN
en-wikipedia-org-4107	277	34	others	other	NNS
en-wikipedia-org-4107	277	35	.	.	.
en-wikipedia-org-4107	278	1	[	[	-LRB-
en-wikipedia-org-4107	278	2	3][226][227	3][226][227	CD
en-wikipedia-org-4107	278	3	]	]	-RRB-
en-wikipedia-org-4107	278	4	These	these	DT
en-wikipedia-org-4107	278	5	compounds	compound	NNS
en-wikipedia-org-4107	278	6	may	may	MD
en-wikipedia-org-4107	278	7	produce	produce	VB
en-wikipedia-org-4107	278	8	positive	positive	JJ
en-wikipedia-org-4107	278	9	results	result	NNS
en-wikipedia-org-4107	278	10	for	for	IN
en-wikipedia-org-4107	278	11	amphetamine	amphetamine	NN
en-wikipedia-org-4107	278	12	on	on	IN
en-wikipedia-org-4107	278	13	drug	drug	NN
en-wikipedia-org-4107	278	14	tests	test	NNS
en-wikipedia-org-4107	278	15	.	.	.
en-wikipedia-org-4107	279	1	[	[	-LRB-
en-wikipedia-org-4107	279	2	226][227	226][227	CD
en-wikipedia-org-4107	279	3	]	]	-RRB-
en-wikipedia-org-4107	279	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	279	5	is	be	VBZ
en-wikipedia-org-4107	279	6	generally	generally	RB
en-wikipedia-org-4107	279	7	only	only	RB
en-wikipedia-org-4107	279	8	detectable	detectable	JJ
en-wikipedia-org-4107	279	9	by	by	IN
en-wikipedia-org-4107	279	10	a	a	DT
en-wikipedia-org-4107	279	11	standard	standard	JJ
en-wikipedia-org-4107	279	12	drug	drug	NN
en-wikipedia-org-4107	279	13	test	test	NN
en-wikipedia-org-4107	279	14	for	for	IN
en-wikipedia-org-4107	279	15	approximately	approximately	RB
en-wikipedia-org-4107	279	16	24	24	CD
en-wikipedia-org-4107	279	17	 	  	_SP
en-wikipedia-org-4107	279	18	hours	hour	NNS
en-wikipedia-org-4107	279	19	,	,	,
en-wikipedia-org-4107	279	20	although	although	IN
en-wikipedia-org-4107	279	21	a	a	DT
en-wikipedia-org-4107	279	22	high	high	JJ
en-wikipedia-org-4107	279	23	dose	dose	NN
en-wikipedia-org-4107	279	24	may	may	MD
en-wikipedia-org-4107	279	25	be	be	VB
en-wikipedia-org-4107	279	26	detectable	detectable	JJ
en-wikipedia-org-4107	279	27	for	for	IN
en-wikipedia-org-4107	279	28	2–4	2–4	CD
en-wikipedia-org-4107	279	29	 	  	_SP
en-wikipedia-org-4107	279	30	days	day	NNS
en-wikipedia-org-4107	279	31	.	.	.
en-wikipedia-org-4107	280	1	[	[	-LRB-
en-wikipedia-org-4107	280	2	220	220	CD
en-wikipedia-org-4107	280	3	]	]	-RRB-
en-wikipedia-org-4107	280	4	For	for	IN
en-wikipedia-org-4107	280	5	the	the	DT
en-wikipedia-org-4107	280	6	assays	assay	NNS
en-wikipedia-org-4107	280	7	,	,	,
en-wikipedia-org-4107	280	8	a	a	DT
en-wikipedia-org-4107	280	9	study	study	NN
en-wikipedia-org-4107	280	10	noted	note	VBD
en-wikipedia-org-4107	280	11	that	that	IN
en-wikipedia-org-4107	280	12	an	an	DT
en-wikipedia-org-4107	280	13	enzyme	enzyme	NNS
en-wikipedia-org-4107	280	14	multiplied	multiply	VBD
en-wikipedia-org-4107	280	15	immunoassay	immunoassay	NN
en-wikipedia-org-4107	280	16	technique	technique	NN
en-wikipedia-org-4107	280	17	(	(	-LRB-
en-wikipedia-org-4107	280	18	EMIT	EMIT	NNP
en-wikipedia-org-4107	280	19	)	)	-RRB-
en-wikipedia-org-4107	280	20	assay	assay	NNP
en-wikipedia-org-4107	280	21	for	for	IN
en-wikipedia-org-4107	280	22	amphetamine	amphetamine	NN
en-wikipedia-org-4107	280	23	and	and	CC
en-wikipedia-org-4107	280	24	methamphetamine	methamphetamine	NNP
en-wikipedia-org-4107	280	25	may	may	MD
en-wikipedia-org-4107	280	26	produce	produce	VB
en-wikipedia-org-4107	280	27	more	more	JJR
en-wikipedia-org-4107	280	28	false	false	JJ
en-wikipedia-org-4107	280	29	positives	positive	NNS
en-wikipedia-org-4107	280	30	than	than	IN
en-wikipedia-org-4107	280	31	liquid	liquid	JJ
en-wikipedia-org-4107	280	32	chromatography	chromatography	NN
en-wikipedia-org-4107	280	33	–	–	:
en-wikipedia-org-4107	280	34	tandem	tandem	NNP
en-wikipedia-org-4107	280	35	mass	mass	NNP
en-wikipedia-org-4107	280	36	spectrometry	spectrometry	NNP
en-wikipedia-org-4107	280	37	.	.	.
en-wikipedia-org-4107	281	1	[	[	-LRB-
en-wikipedia-org-4107	281	2	224	224	CD
en-wikipedia-org-4107	281	3	]	]	-RRB-
en-wikipedia-org-4107	281	4	Gas	gas	NN
en-wikipedia-org-4107	281	5	chromatography	chromatography	NN
en-wikipedia-org-4107	281	6	–	–	:
en-wikipedia-org-4107	281	7	mass	mass	NN
en-wikipedia-org-4107	281	8	spectrometry	spectrometry	NN
en-wikipedia-org-4107	281	9	(	(	-LRB-
en-wikipedia-org-4107	281	10	GC	GC	NNP
en-wikipedia-org-4107	281	11	–	–	:
en-wikipedia-org-4107	281	12	MS	MS	NNP
en-wikipedia-org-4107	281	13	)	)	-RRB-
en-wikipedia-org-4107	281	14	of	of	IN
en-wikipedia-org-4107	281	15	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	281	16	and	and	CC
en-wikipedia-org-4107	281	17	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	281	18	with	with	IN
en-wikipedia-org-4107	281	19	the	the	DT
en-wikipedia-org-4107	281	20	derivatizing	derivatize	VBG
en-wikipedia-org-4107	281	21	agent	agent	NN
en-wikipedia-org-4107	281	22	(	(	-LRB-
en-wikipedia-org-4107	281	23	S)-(−)-trifluoroacetylprolyl	S)-(−)-trifluoroacetylprolyl	``
en-wikipedia-org-4107	281	24	chloride	chloride	NN
en-wikipedia-org-4107	281	25	allows	allow	VBZ
en-wikipedia-org-4107	281	26	for	for	IN
en-wikipedia-org-4107	281	27	the	the	DT
en-wikipedia-org-4107	281	28	detection	detection	NN
en-wikipedia-org-4107	281	29	of	of	IN
en-wikipedia-org-4107	281	30	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	281	31	in	in	IN
en-wikipedia-org-4107	281	32	urine	urine	NN
en-wikipedia-org-4107	281	33	.	.	.
en-wikipedia-org-4107	282	1	[	[	-LRB-
en-wikipedia-org-4107	282	2	221	221	CD
en-wikipedia-org-4107	282	3	]	]	-RRB-
en-wikipedia-org-4107	282	4	GC	GC	NNP
en-wikipedia-org-4107	282	5	–	–	:
en-wikipedia-org-4107	282	6	MS	MS	NNP
en-wikipedia-org-4107	282	7	of	of	IN
en-wikipedia-org-4107	282	8	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	282	9	and	and	CC
en-wikipedia-org-4107	282	10	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	282	11	with	with	IN
en-wikipedia-org-4107	282	12	the	the	DT
en-wikipedia-org-4107	282	13	chiral	chiral	JJ
en-wikipedia-org-4107	282	14	derivatizing	derivatize	VBG
en-wikipedia-org-4107	282	15	agent	agent	NN
en-wikipedia-org-4107	282	16	Mosher	Mosher	NNP
en-wikipedia-org-4107	282	17	's	's	POS
en-wikipedia-org-4107	282	18	 	  	_SP
en-wikipedia-org-4107	282	19	acid	acid	NN
en-wikipedia-org-4107	282	20	chloride	chloride	NN
en-wikipedia-org-4107	282	21	allows	allow	VBZ
en-wikipedia-org-4107	282	22	for	for	IN
en-wikipedia-org-4107	282	23	the	the	DT
en-wikipedia-org-4107	282	24	detection	detection	NN
en-wikipedia-org-4107	282	25	of	of	IN
en-wikipedia-org-4107	282	26	both	both	CC
en-wikipedia-org-4107	282	27	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	282	28	and	and	CC
en-wikipedia-org-4107	282	29	dextromethamphetamine	dextromethamphetamine	NN
en-wikipedia-org-4107	282	30	in	in	IN
en-wikipedia-org-4107	282	31	urine	urine	NN
en-wikipedia-org-4107	282	32	.	.	.
en-wikipedia-org-4107	283	1	[	[	-LRB-
en-wikipedia-org-4107	283	2	221	221	CD
en-wikipedia-org-4107	283	3	]	]	-RRB-
en-wikipedia-org-4107	283	4	Hence	hence	RB
en-wikipedia-org-4107	283	5	,	,	,
en-wikipedia-org-4107	283	6	the	the	DT
en-wikipedia-org-4107	283	7	latter	latter	JJ
en-wikipedia-org-4107	283	8	method	method	NN
en-wikipedia-org-4107	283	9	may	may	MD
en-wikipedia-org-4107	283	10	be	be	VB
en-wikipedia-org-4107	283	11	used	use	VBN
en-wikipedia-org-4107	283	12	on	on	IN
en-wikipedia-org-4107	283	13	samples	sample	NNS
en-wikipedia-org-4107	283	14	that	that	WDT
en-wikipedia-org-4107	283	15	test	test	VBP
en-wikipedia-org-4107	283	16	positive	positive	JJ
en-wikipedia-org-4107	283	17	using	use	VBG
en-wikipedia-org-4107	283	18	other	other	JJ
en-wikipedia-org-4107	283	19	methods	method	NNS
en-wikipedia-org-4107	283	20	to	to	TO
en-wikipedia-org-4107	283	21	help	help	VB
en-wikipedia-org-4107	283	22	distinguish	distinguish	VB
en-wikipedia-org-4107	283	23	between	between	IN
en-wikipedia-org-4107	283	24	the	the	DT
en-wikipedia-org-4107	283	25	various	various	JJ
en-wikipedia-org-4107	283	26	sources	source	NNS
en-wikipedia-org-4107	283	27	of	of	IN
en-wikipedia-org-4107	283	28	the	the	DT
en-wikipedia-org-4107	283	29	drug	drug	NN
en-wikipedia-org-4107	283	30	.	.	.
en-wikipedia-org-4107	284	1	[	[	-LRB-
en-wikipedia-org-4107	284	2	221	221	CD
en-wikipedia-org-4107	284	3	]	]	-RRB-
en-wikipedia-org-4107	284	4	History	history	NN
en-wikipedia-org-4107	284	5	,	,	,
en-wikipedia-org-4107	284	6	society	society	NN
en-wikipedia-org-4107	284	7	,	,	,
en-wikipedia-org-4107	284	8	and	and	CC
en-wikipedia-org-4107	284	9	culture	culture	NN
en-wikipedia-org-4107	284	10	Main	main	JJ
en-wikipedia-org-4107	284	11	article	article	NN
en-wikipedia-org-4107	284	12	:	:	:
en-wikipedia-org-4107	284	13	History	history	NN
en-wikipedia-org-4107	284	14	and	and	CC
en-wikipedia-org-4107	284	15	culture	culture	NN
en-wikipedia-org-4107	284	16	of	of	IN
en-wikipedia-org-4107	284	17	substituted	substitute	VBN
en-wikipedia-org-4107	284	18	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	284	19	Global	global	JJ
en-wikipedia-org-4107	284	20	estimates	estimate	NNS
en-wikipedia-org-4107	284	21	of	of	IN
en-wikipedia-org-4107	284	22	drug	drug	NN
en-wikipedia-org-4107	284	23	users	user	NNS
en-wikipedia-org-4107	284	24	in	in	IN
en-wikipedia-org-4107	284	25	2016	2016	CD
en-wikipedia-org-4107	284	26	(	(	-LRB-
en-wikipedia-org-4107	284	27	in	in	IN
en-wikipedia-org-4107	284	28	millions	million	NNS
en-wikipedia-org-4107	284	29	of	of	IN
en-wikipedia-org-4107	284	30	users)[228	users)[228	NNP
en-wikipedia-org-4107	284	31	]	]	-RRB-
en-wikipedia-org-4107	284	32	Substance	Substance	NNP
en-wikipedia-org-4107	284	33	Best	Best	NNP
en-wikipedia-org-4107	284	34	estimate	estimate	VBP
en-wikipedia-org-4107	284	35	Low	low	JJ
en-wikipedia-org-4107	284	36	estimate	estimate	NN
en-wikipedia-org-4107	284	37	High	high	JJ
en-wikipedia-org-4107	284	38	estimate	estimate	NN
en-wikipedia-org-4107	284	39	Amphetamine-	Amphetamine-	NNP
en-wikipedia-org-4107	284	40	type	type	NN
en-wikipedia-org-4107	284	41	stimulants	stimulant	NNS
en-wikipedia-org-4107	284	42	34.16	34.16	CD
en-wikipedia-org-4107	284	43	13.42	13.42	CD
en-wikipedia-org-4107	284	44	55.24	55.24	CD
en-wikipedia-org-4107	284	45	Cannabis	Cannabis	NNP
en-wikipedia-org-4107	284	46	192.15	192.15	CD
en-wikipedia-org-4107	284	47	165.76	165.76	CD
en-wikipedia-org-4107	284	48	234.06	234.06	CD
en-wikipedia-org-4107	284	49	Cocaine	Cocaine	NNP
en-wikipedia-org-4107	284	50	18.20	18.20	CD
en-wikipedia-org-4107	284	51	13.87	13.87	CD
en-wikipedia-org-4107	284	52	22.85	22.85	CD
en-wikipedia-org-4107	284	53	Ecstasy	Ecstasy	NNP
en-wikipedia-org-4107	284	54	20.57	20.57	CD
en-wikipedia-org-4107	284	55	8.99	8.99	CD
en-wikipedia-org-4107	284	56	32.34	32.34	CD
en-wikipedia-org-4107	284	57	Opiates	Opiates	NNPS
en-wikipedia-org-4107	284	58	19.38	19.38	CD
en-wikipedia-org-4107	284	59	13.80	13.80	CD
en-wikipedia-org-4107	284	60	26.15	26.15	CD
en-wikipedia-org-4107	284	61	Opioids	opioid	NNS
en-wikipedia-org-4107	284	62	34.26	34.26	CD
en-wikipedia-org-4107	284	63	27.01	27.01	CD
en-wikipedia-org-4107	284	64	44.54	44.54	CD
en-wikipedia-org-4107	284	65	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	284	66	was	be	VBD
en-wikipedia-org-4107	284	67	first	first	RB
en-wikipedia-org-4107	284	68	synthesized	synthesize	VBN
en-wikipedia-org-4107	284	69	in	in	IN
en-wikipedia-org-4107	284	70	1887	1887	CD
en-wikipedia-org-4107	284	71	in	in	IN
en-wikipedia-org-4107	284	72	Germany	Germany	NNP
en-wikipedia-org-4107	284	73	by	by	IN
en-wikipedia-org-4107	284	74	Romanian	romanian	JJ
en-wikipedia-org-4107	284	75	chemist	chemist	NN
en-wikipedia-org-4107	284	76	Lazăr	Lazăr	NNP
en-wikipedia-org-4107	284	77	Edeleanu	Edeleanu	NNP
en-wikipedia-org-4107	284	78	who	who	WP
en-wikipedia-org-4107	284	79	named	name	VBD
en-wikipedia-org-4107	284	80	it	-PRON-	PRP
en-wikipedia-org-4107	284	81	phenylisopropylamine;[205][229][230	phenylisopropylamine;[205][229][230	ADD
en-wikipedia-org-4107	284	82	]	]	-RRB-
en-wikipedia-org-4107	284	83	its	-PRON-	PRP$
en-wikipedia-org-4107	284	84	stimulant	stimulant	NN
en-wikipedia-org-4107	284	85	effects	effect	NNS
en-wikipedia-org-4107	284	86	remained	remain	VBD
en-wikipedia-org-4107	284	87	unknown	unknown	JJ
en-wikipedia-org-4107	284	88	until	until	IN
en-wikipedia-org-4107	284	89	1927	1927	CD
en-wikipedia-org-4107	284	90	,	,	,
en-wikipedia-org-4107	284	91	when	when	WRB
en-wikipedia-org-4107	284	92	it	-PRON-	PRP
en-wikipedia-org-4107	284	93	was	be	VBD
en-wikipedia-org-4107	284	94	independently	independently	RB
en-wikipedia-org-4107	284	95	resynthesized	resynthesize	VBN
en-wikipedia-org-4107	284	96	by	by	IN
en-wikipedia-org-4107	284	97	Gordon	Gordon	NNP
en-wikipedia-org-4107	284	98	Alles	Alles	NNP
en-wikipedia-org-4107	284	99	and	and	CC
en-wikipedia-org-4107	284	100	reported	report	VBD
en-wikipedia-org-4107	284	101	to	to	TO
en-wikipedia-org-4107	284	102	have	have	VB
en-wikipedia-org-4107	284	103	sympathomimetic	sympathomimetic	JJ
en-wikipedia-org-4107	284	104	properties	property	NNS
en-wikipedia-org-4107	284	105	.	.	.
en-wikipedia-org-4107	285	1	[	[	-LRB-
en-wikipedia-org-4107	285	2	230	230	CD
en-wikipedia-org-4107	285	3	]	]	-RRB-
en-wikipedia-org-4107	285	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	285	5	had	have	VBD
en-wikipedia-org-4107	285	6	no	no	DT
en-wikipedia-org-4107	285	7	medical	medical	JJ
en-wikipedia-org-4107	285	8	use	use	NN
en-wikipedia-org-4107	285	9	until	until	IN
en-wikipedia-org-4107	285	10	late	late	JJ
en-wikipedia-org-4107	285	11	1933	1933	CD
en-wikipedia-org-4107	285	12	,	,	,
en-wikipedia-org-4107	285	13	when	when	WRB
en-wikipedia-org-4107	285	14	Smith	Smith	NNP
en-wikipedia-org-4107	285	15	,	,	,
en-wikipedia-org-4107	285	16	Kline	Kline	NNP
en-wikipedia-org-4107	285	17	and	and	CC
en-wikipedia-org-4107	285	18	French	French	NNP
en-wikipedia-org-4107	285	19	began	begin	VBD
en-wikipedia-org-4107	285	20	selling	sell	VBG
en-wikipedia-org-4107	285	21	it	-PRON-	PRP
en-wikipedia-org-4107	285	22	as	as	IN
en-wikipedia-org-4107	285	23	an	an	DT
en-wikipedia-org-4107	285	24	inhaler	inhaler	NN
en-wikipedia-org-4107	285	25	under	under	IN
en-wikipedia-org-4107	285	26	the	the	DT
en-wikipedia-org-4107	285	27	brand	brand	NN
en-wikipedia-org-4107	285	28	name	name	NN
en-wikipedia-org-4107	285	29	Benzedrine	Benzedrine	NNP
en-wikipedia-org-4107	285	30	as	as	IN
en-wikipedia-org-4107	285	31	a	a	DT
en-wikipedia-org-4107	285	32	decongestant	decongestant	NN
en-wikipedia-org-4107	285	33	.	.	.
en-wikipedia-org-4107	286	1	[	[	-LRB-
en-wikipedia-org-4107	286	2	29	29	CD
en-wikipedia-org-4107	286	3	]	]	-RRB-
en-wikipedia-org-4107	286	4	Benzedrine	Benzedrine	NNP
en-wikipedia-org-4107	286	5	sulfate	sulfate	NN
en-wikipedia-org-4107	286	6	was	be	VBD
en-wikipedia-org-4107	286	7	introduced	introduce	VBN
en-wikipedia-org-4107	286	8	3	3	CD
en-wikipedia-org-4107	286	9	 	  	_SP
en-wikipedia-org-4107	286	10	years	year	NNS
en-wikipedia-org-4107	286	11	later	later	RB
en-wikipedia-org-4107	286	12	and	and	CC
en-wikipedia-org-4107	286	13	was	be	VBD
en-wikipedia-org-4107	286	14	used	use	VBN
en-wikipedia-org-4107	286	15	to	to	TO
en-wikipedia-org-4107	286	16	treat	treat	VB
en-wikipedia-org-4107	286	17	a	a	DT
en-wikipedia-org-4107	286	18	wide	wide	JJ
en-wikipedia-org-4107	286	19	variety	variety	NN
en-wikipedia-org-4107	286	20	of	of	IN
en-wikipedia-org-4107	286	21	medical	medical	JJ
en-wikipedia-org-4107	286	22	conditions	condition	NNS
en-wikipedia-org-4107	286	23	,	,	,
en-wikipedia-org-4107	286	24	including	include	VBG
en-wikipedia-org-4107	286	25	narcolepsy	narcolepsy	NN
en-wikipedia-org-4107	286	26	,	,	,
en-wikipedia-org-4107	286	27	obesity	obesity	NN
en-wikipedia-org-4107	286	28	,	,	,
en-wikipedia-org-4107	286	29	low	low	JJ
en-wikipedia-org-4107	286	30	blood	blood	NN
en-wikipedia-org-4107	286	31	pressure	pressure	NN
en-wikipedia-org-4107	286	32	,	,	,
en-wikipedia-org-4107	286	33	low	low	JJ
en-wikipedia-org-4107	286	34	libido	libido	NN
en-wikipedia-org-4107	286	35	,	,	,
en-wikipedia-org-4107	286	36	and	and	CC
en-wikipedia-org-4107	286	37	chronic	chronic	JJ
en-wikipedia-org-4107	286	38	pain	pain	NN
en-wikipedia-org-4107	286	39	,	,	,
en-wikipedia-org-4107	286	40	among	among	IN
en-wikipedia-org-4107	286	41	others	other	NNS
en-wikipedia-org-4107	286	42	.	.	.
en-wikipedia-org-4107	287	1	[	[	-LRB-
en-wikipedia-org-4107	287	2	49][29	49][29	CD
en-wikipedia-org-4107	287	3	]	]	-RRB-
en-wikipedia-org-4107	287	4	During	during	IN
en-wikipedia-org-4107	287	5	World	World	NNP
en-wikipedia-org-4107	287	6	War	War	NNP
en-wikipedia-org-4107	287	7	II	II	NNP
en-wikipedia-org-4107	287	8	,	,	,
en-wikipedia-org-4107	287	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	287	10	and	and	CC
en-wikipedia-org-4107	287	11	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	287	12	were	be	VBD
en-wikipedia-org-4107	287	13	used	use	VBN
en-wikipedia-org-4107	287	14	extensively	extensively	RB
en-wikipedia-org-4107	287	15	by	by	IN
en-wikipedia-org-4107	287	16	both	both	DT
en-wikipedia-org-4107	287	17	the	the	DT
en-wikipedia-org-4107	287	18	Allied	Allied	NNP
en-wikipedia-org-4107	287	19	and	and	CC
en-wikipedia-org-4107	287	20	Axis	Axis	NNP
en-wikipedia-org-4107	287	21	forces	force	NNS
en-wikipedia-org-4107	287	22	for	for	IN
en-wikipedia-org-4107	287	23	their	-PRON-	PRP$
en-wikipedia-org-4107	287	24	stimulant	stimulant	NN
en-wikipedia-org-4107	287	25	and	and	CC
en-wikipedia-org-4107	287	26	performance	performance	NN
en-wikipedia-org-4107	287	27	-	-	HYPH
en-wikipedia-org-4107	287	28	enhancing	enhance	VBG
en-wikipedia-org-4107	287	29	effects	effect	NNS
en-wikipedia-org-4107	287	30	.	.	.
en-wikipedia-org-4107	288	1	[	[	-LRB-
en-wikipedia-org-4107	288	2	205][231][232	205][231][232	CD
en-wikipedia-org-4107	288	3	]	]	-RRB-
en-wikipedia-org-4107	288	4	As	as	IN
en-wikipedia-org-4107	288	5	the	the	DT
en-wikipedia-org-4107	288	6	addictive	addictive	JJ
en-wikipedia-org-4107	288	7	properties	property	NNS
en-wikipedia-org-4107	288	8	of	of	IN
en-wikipedia-org-4107	288	9	the	the	DT
en-wikipedia-org-4107	288	10	drug	drug	NN
en-wikipedia-org-4107	288	11	became	become	VBD
en-wikipedia-org-4107	288	12	known	know	VBN
en-wikipedia-org-4107	288	13	,	,	,
en-wikipedia-org-4107	288	14	governments	government	NNS
en-wikipedia-org-4107	288	15	began	begin	VBD
en-wikipedia-org-4107	288	16	to	to	TO
en-wikipedia-org-4107	288	17	place	place	VB
en-wikipedia-org-4107	288	18	strict	strict	JJ
en-wikipedia-org-4107	288	19	controls	control	NNS
en-wikipedia-org-4107	288	20	on	on	IN
en-wikipedia-org-4107	288	21	the	the	DT
en-wikipedia-org-4107	288	22	sale	sale	NN
en-wikipedia-org-4107	288	23	of	of	IN
en-wikipedia-org-4107	288	24	amphetamine	amphetamine	NN
en-wikipedia-org-4107	288	25	.	.	.
en-wikipedia-org-4107	289	1	[	[	-LRB-
en-wikipedia-org-4107	289	2	205	205	CD
en-wikipedia-org-4107	289	3	]	]	-RRB-
en-wikipedia-org-4107	289	4	For	for	IN
en-wikipedia-org-4107	289	5	example	example	NN
en-wikipedia-org-4107	289	6	,	,	,
en-wikipedia-org-4107	289	7	during	during	IN
en-wikipedia-org-4107	289	8	the	the	DT
en-wikipedia-org-4107	289	9	early	early	JJ
en-wikipedia-org-4107	289	10	1970s	1970	NNS
en-wikipedia-org-4107	289	11	in	in	IN
en-wikipedia-org-4107	289	12	the	the	DT
en-wikipedia-org-4107	289	13	United	United	NNP
en-wikipedia-org-4107	289	14	States	States	NNP
en-wikipedia-org-4107	289	15	,	,	,
en-wikipedia-org-4107	289	16	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	289	17	became	become	VBD
en-wikipedia-org-4107	289	18	a	a	DT
en-wikipedia-org-4107	289	19	schedule	schedule	NN
en-wikipedia-org-4107	289	20	 	  	_SP
en-wikipedia-org-4107	289	21	II	II	NNP
en-wikipedia-org-4107	289	22	controlled	control	VBN
en-wikipedia-org-4107	289	23	substance	substance	NN
en-wikipedia-org-4107	289	24	under	under	IN
en-wikipedia-org-4107	289	25	the	the	DT
en-wikipedia-org-4107	289	26	Controlled	Controlled	NNP
en-wikipedia-org-4107	289	27	Substances	Substances	NNPS
en-wikipedia-org-4107	289	28	Act	Act	NNP
en-wikipedia-org-4107	289	29	.	.	.
en-wikipedia-org-4107	290	1	[	[	-LRB-
en-wikipedia-org-4107	290	2	233][234	233][234	CD
en-wikipedia-org-4107	290	3	]	]	-RRB-
en-wikipedia-org-4107	290	4	In	in	IN
en-wikipedia-org-4107	290	5	spite	spite	NN
en-wikipedia-org-4107	290	6	of	of	IN
en-wikipedia-org-4107	290	7	strict	strict	JJ
en-wikipedia-org-4107	290	8	government	government	NN
en-wikipedia-org-4107	290	9	controls	control	NNS
en-wikipedia-org-4107	290	10	,	,	,
en-wikipedia-org-4107	290	11	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	290	12	has	have	VBZ
en-wikipedia-org-4107	290	13	been	be	VBN
en-wikipedia-org-4107	290	14	used	use	VBN
en-wikipedia-org-4107	290	15	legally	legally	RB
en-wikipedia-org-4107	290	16	or	or	CC
en-wikipedia-org-4107	290	17	illicitly	illicitly	RB
en-wikipedia-org-4107	290	18	by	by	IN
en-wikipedia-org-4107	290	19	people	people	NNS
en-wikipedia-org-4107	290	20	from	from	IN
en-wikipedia-org-4107	290	21	a	a	DT
en-wikipedia-org-4107	290	22	variety	variety	NN
en-wikipedia-org-4107	290	23	of	of	IN
en-wikipedia-org-4107	290	24	backgrounds	background	NNS
en-wikipedia-org-4107	290	25	,	,	,
en-wikipedia-org-4107	290	26	including	include	VBG
en-wikipedia-org-4107	290	27	authors,[235	authors,[235	NNP
en-wikipedia-org-4107	290	28	]	]	-RRB-
en-wikipedia-org-4107	290	29	musicians,[236	musicians,[236	NNP
en-wikipedia-org-4107	290	30	]	]	-RRB-
en-wikipedia-org-4107	290	31	mathematicians,[237	mathematicians,[237	NN
en-wikipedia-org-4107	290	32	]	]	-RRB-
en-wikipedia-org-4107	290	33	and	and	CC
en-wikipedia-org-4107	290	34	athletes	athlete	NNS
en-wikipedia-org-4107	290	35	.	.	.
en-wikipedia-org-4107	291	1	[	[	-LRB-
en-wikipedia-org-4107	291	2	27	27	CD
en-wikipedia-org-4107	291	3	]	]	-RRB-
en-wikipedia-org-4107	291	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	291	5	is	be	VBZ
en-wikipedia-org-4107	291	6	still	still	RB
en-wikipedia-org-4107	291	7	illegally	illegally	RB
en-wikipedia-org-4107	291	8	synthesized	synthesize	VBN
en-wikipedia-org-4107	291	9	today	today	NN
en-wikipedia-org-4107	291	10	in	in	IN
en-wikipedia-org-4107	291	11	clandestine	clandestine	JJ
en-wikipedia-org-4107	291	12	labs	lab	NNS
en-wikipedia-org-4107	291	13	and	and	CC
en-wikipedia-org-4107	291	14	sold	sell	VBN
en-wikipedia-org-4107	291	15	on	on	IN
en-wikipedia-org-4107	291	16	the	the	DT
en-wikipedia-org-4107	291	17	black	black	JJ
en-wikipedia-org-4107	291	18	market	market	NN
en-wikipedia-org-4107	291	19	,	,	,
en-wikipedia-org-4107	291	20	primarily	primarily	RB
en-wikipedia-org-4107	291	21	in	in	IN
en-wikipedia-org-4107	291	22	European	european	JJ
en-wikipedia-org-4107	291	23	countries	country	NNS
en-wikipedia-org-4107	291	24	.	.	.
en-wikipedia-org-4107	292	1	[	[	-LRB-
en-wikipedia-org-4107	292	2	238	238	CD
en-wikipedia-org-4107	292	3	]	]	-RRB-
en-wikipedia-org-4107	292	4	Among	among	IN
en-wikipedia-org-4107	292	5	European	European	NNP
en-wikipedia-org-4107	292	6	Union	Union	NNP
en-wikipedia-org-4107	292	7	(	(	-LRB-
en-wikipedia-org-4107	292	8	EU	EU	NNP
en-wikipedia-org-4107	292	9	)	)	-RRB-
en-wikipedia-org-4107	292	10	member	member	NN
en-wikipedia-org-4107	292	11	states	state	NNS
en-wikipedia-org-4107	292	12	in	in	IN
en-wikipedia-org-4107	292	13	2018,[update	2018,[update	NN
en-wikipedia-org-4107	292	14	]	]	-RRB-
en-wikipedia-org-4107	292	15	11.9	11.9	CD
en-wikipedia-org-4107	292	16	 	  	_SP
en-wikipedia-org-4107	292	17	million	million	CD
en-wikipedia-org-4107	292	18	adults	adult	NNS
en-wikipedia-org-4107	292	19	of	of	IN
en-wikipedia-org-4107	292	20	ages	age	NNS
en-wikipedia-org-4107	292	21	15–64	15–64	CD
en-wikipedia-org-4107	292	22	have	have	VBP
en-wikipedia-org-4107	292	23	used	use	VBN
en-wikipedia-org-4107	292	24	amphetamine	amphetamine	NN
en-wikipedia-org-4107	292	25	or	or	CC
en-wikipedia-org-4107	292	26	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	292	27	at	at	IN
en-wikipedia-org-4107	292	28	least	least	JJS
en-wikipedia-org-4107	292	29	once	once	RB
en-wikipedia-org-4107	292	30	in	in	IN
en-wikipedia-org-4107	292	31	their	-PRON-	PRP$
en-wikipedia-org-4107	292	32	lives	life	NNS
en-wikipedia-org-4107	292	33	and	and	CC
en-wikipedia-org-4107	292	34	1.7	1.7	CD
en-wikipedia-org-4107	292	35	 	  	_SP
en-wikipedia-org-4107	292	36	million	million	CD
en-wikipedia-org-4107	292	37	have	have	VBP
en-wikipedia-org-4107	292	38	used	use	VBN
en-wikipedia-org-4107	292	39	either	either	CC
en-wikipedia-org-4107	292	40	in	in	IN
en-wikipedia-org-4107	292	41	the	the	DT
en-wikipedia-org-4107	292	42	last	last	JJ
en-wikipedia-org-4107	292	43	year	year	NN
en-wikipedia-org-4107	292	44	.	.	.
en-wikipedia-org-4107	293	1	[	[	-LRB-
en-wikipedia-org-4107	293	2	239	239	CD
en-wikipedia-org-4107	293	3	]	]	-RRB-
en-wikipedia-org-4107	293	4	During	during	IN
en-wikipedia-org-4107	293	5	2012	2012	CD
en-wikipedia-org-4107	293	6	,	,	,
en-wikipedia-org-4107	293	7	approximately	approximately	RB
en-wikipedia-org-4107	293	8	5.9	5.9	CD
en-wikipedia-org-4107	293	9	 	  	_SP
en-wikipedia-org-4107	293	10	metric	metric	JJ
en-wikipedia-org-4107	293	11	tons	ton	NNS
en-wikipedia-org-4107	293	12	of	of	IN
en-wikipedia-org-4107	293	13	illicit	illicit	JJ
en-wikipedia-org-4107	293	14	amphetamine	amphetamine	NN
en-wikipedia-org-4107	293	15	were	be	VBD
en-wikipedia-org-4107	293	16	seized	seize	VBN
en-wikipedia-org-4107	293	17	within	within	IN
en-wikipedia-org-4107	293	18	EU	EU	NNP
en-wikipedia-org-4107	293	19	member	member	NN
en-wikipedia-org-4107	293	20	states;[240	states;[240	NNS
en-wikipedia-org-4107	293	21	]	]	-RRB-
en-wikipedia-org-4107	293	22	the	the	DT
en-wikipedia-org-4107	293	23	"	"	``
en-wikipedia-org-4107	293	24	street	street	NN
en-wikipedia-org-4107	293	25	price	price	NN
en-wikipedia-org-4107	293	26	"	"	''
en-wikipedia-org-4107	293	27	of	of	IN
en-wikipedia-org-4107	293	28	illicit	illicit	JJ
en-wikipedia-org-4107	293	29	amphetamine	amphetamine	NN
en-wikipedia-org-4107	293	30	within	within	IN
en-wikipedia-org-4107	293	31	the	the	DT
en-wikipedia-org-4107	293	32	EU	EU	NNP
en-wikipedia-org-4107	293	33	ranged	range	VBD
en-wikipedia-org-4107	293	34	from	from	IN
en-wikipedia-org-4107	293	35	€	€	NNP
en-wikipedia-org-4107	293	36	6–38	6–38	NNPS
en-wikipedia-org-4107	293	37	 	  	_SP
en-wikipedia-org-4107	293	38	per	per	IN
en-wikipedia-org-4107	293	39	gram	gram	NN
en-wikipedia-org-4107	293	40	during	during	IN
en-wikipedia-org-4107	293	41	the	the	DT
en-wikipedia-org-4107	293	42	same	same	JJ
en-wikipedia-org-4107	293	43	period	period	NN
en-wikipedia-org-4107	293	44	.	.	.
en-wikipedia-org-4107	294	1	[	[	-LRB-
en-wikipedia-org-4107	294	2	240	240	CD
en-wikipedia-org-4107	294	3	]	]	-RRB-
en-wikipedia-org-4107	294	4	Outside	outside	IN
en-wikipedia-org-4107	294	5	Europe	Europe	NNP
en-wikipedia-org-4107	294	6	,	,	,
en-wikipedia-org-4107	294	7	the	the	DT
en-wikipedia-org-4107	294	8	illicit	illicit	JJ
en-wikipedia-org-4107	294	9	market	market	NN
en-wikipedia-org-4107	294	10	for	for	IN
en-wikipedia-org-4107	294	11	amphetamine	amphetamine	NN
en-wikipedia-org-4107	294	12	is	be	VBZ
en-wikipedia-org-4107	294	13	much	much	RB
en-wikipedia-org-4107	294	14	smaller	small	JJR
en-wikipedia-org-4107	294	15	than	than	IN
en-wikipedia-org-4107	294	16	the	the	DT
en-wikipedia-org-4107	294	17	market	market	NN
en-wikipedia-org-4107	294	18	for	for	IN
en-wikipedia-org-4107	294	19	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	294	20	and	and	CC
en-wikipedia-org-4107	294	21	MDMA	mdma	NN
en-wikipedia-org-4107	294	22	.	.	.
en-wikipedia-org-4107	295	1	[	[	-LRB-
en-wikipedia-org-4107	295	2	238	238	CD
en-wikipedia-org-4107	295	3	]	]	-RRB-
en-wikipedia-org-4107	295	4	Legal	legal	JJ
en-wikipedia-org-4107	295	5	status	status	NN
en-wikipedia-org-4107	295	6	As	as	IN
en-wikipedia-org-4107	295	7	a	a	DT
en-wikipedia-org-4107	295	8	result	result	NN
en-wikipedia-org-4107	295	9	of	of	IN
en-wikipedia-org-4107	295	10	the	the	DT
en-wikipedia-org-4107	295	11	United	United	NNP
en-wikipedia-org-4107	295	12	Nations	Nations	NNP
en-wikipedia-org-4107	295	13	1971	1971	CD
en-wikipedia-org-4107	295	14	Convention	Convention	NNP
en-wikipedia-org-4107	295	15	on	on	IN
en-wikipedia-org-4107	295	16	Psychotropic	Psychotropic	NNP
en-wikipedia-org-4107	295	17	Substances	Substances	NNP
en-wikipedia-org-4107	295	18	,	,	,
en-wikipedia-org-4107	295	19	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	295	20	became	become	VBD
en-wikipedia-org-4107	295	21	a	a	DT
en-wikipedia-org-4107	295	22	schedule	schedule	NN
en-wikipedia-org-4107	295	23	 	  	_SP
en-wikipedia-org-4107	295	24	II	II	NNP
en-wikipedia-org-4107	295	25	controlled	control	VBN
en-wikipedia-org-4107	295	26	substance	substance	NN
en-wikipedia-org-4107	295	27	,	,	,
en-wikipedia-org-4107	295	28	as	as	IN
en-wikipedia-org-4107	295	29	defined	define	VBN
en-wikipedia-org-4107	295	30	in	in	IN
en-wikipedia-org-4107	295	31	the	the	DT
en-wikipedia-org-4107	295	32	treaty	treaty	NN
en-wikipedia-org-4107	295	33	,	,	,
en-wikipedia-org-4107	295	34	in	in	IN
en-wikipedia-org-4107	295	35	all	all	DT
en-wikipedia-org-4107	295	36	183	183	CD
en-wikipedia-org-4107	295	37	state	state	NN
en-wikipedia-org-4107	295	38	parties	party	NNS
en-wikipedia-org-4107	295	39	.	.	.
en-wikipedia-org-4107	296	1	[	[	-LRB-
en-wikipedia-org-4107	296	2	30	30	CD
en-wikipedia-org-4107	296	3	]	]	-RRB-
en-wikipedia-org-4107	296	4	Consequently	consequently	RB
en-wikipedia-org-4107	296	5	,	,	,
en-wikipedia-org-4107	296	6	it	-PRON-	PRP
en-wikipedia-org-4107	296	7	is	be	VBZ
en-wikipedia-org-4107	296	8	heavily	heavily	RB
en-wikipedia-org-4107	296	9	regulated	regulated	JJ
en-wikipedia-org-4107	296	10	in	in	IN
en-wikipedia-org-4107	296	11	most	most	JJS
en-wikipedia-org-4107	296	12	countries	country	NNS
en-wikipedia-org-4107	296	13	.	.	.
en-wikipedia-org-4107	297	1	[	[	-LRB-
en-wikipedia-org-4107	297	2	241][242	241][242	CD
en-wikipedia-org-4107	297	3	]	]	-RRB-
en-wikipedia-org-4107	297	4	Some	some	DT
en-wikipedia-org-4107	297	5	countries	country	NNS
en-wikipedia-org-4107	297	6	,	,	,
en-wikipedia-org-4107	297	7	such	such	JJ
en-wikipedia-org-4107	297	8	as	as	IN
en-wikipedia-org-4107	297	9	South	South	NNP
en-wikipedia-org-4107	297	10	Korea	Korea	NNP
en-wikipedia-org-4107	297	11	and	and	CC
en-wikipedia-org-4107	297	12	Japan	Japan	NNP
en-wikipedia-org-4107	297	13	,	,	,
en-wikipedia-org-4107	297	14	have	have	VBP
en-wikipedia-org-4107	297	15	banned	ban	VBN
en-wikipedia-org-4107	297	16	substituted	substitute	VBN
en-wikipedia-org-4107	297	17	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	297	18	even	even	RB
en-wikipedia-org-4107	297	19	for	for	IN
en-wikipedia-org-4107	297	20	medical	medical	JJ
en-wikipedia-org-4107	297	21	use	use	NN
en-wikipedia-org-4107	297	22	.	.	.
en-wikipedia-org-4107	298	1	[	[	-LRB-
en-wikipedia-org-4107	298	2	243][244	243][244	CD
en-wikipedia-org-4107	298	3	]	]	-RRB-
en-wikipedia-org-4107	298	4	In	in	IN
en-wikipedia-org-4107	298	5	other	other	JJ
en-wikipedia-org-4107	298	6	nations	nation	NNS
en-wikipedia-org-4107	298	7	,	,	,
en-wikipedia-org-4107	298	8	such	such	JJ
en-wikipedia-org-4107	298	9	as	as	IN
en-wikipedia-org-4107	298	10	Canada	Canada	NNP
en-wikipedia-org-4107	298	11	(	(	-LRB-
en-wikipedia-org-4107	298	12	schedule	schedule	NN
en-wikipedia-org-4107	298	13	 	  	_SP
en-wikipedia-org-4107	298	14	I	-PRON-	PRP
en-wikipedia-org-4107	298	15	drug),[245	drug),[245	VBP
en-wikipedia-org-4107	298	16	]	]	-RRB-
en-wikipedia-org-4107	298	17	the	the	DT
en-wikipedia-org-4107	298	18	Netherlands	Netherlands	NNP
en-wikipedia-org-4107	298	19	(	(	-LRB-
en-wikipedia-org-4107	298	20	List	List	NNP
en-wikipedia-org-4107	298	21	 	  	_SP
en-wikipedia-org-4107	298	22	I	-PRON-	PRP
en-wikipedia-org-4107	298	23	drug),[246	drug),[246	VBZ
en-wikipedia-org-4107	298	24	]	]	-RRB-
en-wikipedia-org-4107	298	25	the	the	DT
en-wikipedia-org-4107	298	26	United	United	NNP
en-wikipedia-org-4107	298	27	States	States	NNP
en-wikipedia-org-4107	298	28	(	(	-LRB-
en-wikipedia-org-4107	298	29	schedule	schedule	NN
en-wikipedia-org-4107	298	30	 	  	_SP
en-wikipedia-org-4107	298	31	II	II	NNP
en-wikipedia-org-4107	298	32	drug),[28	drug),[28	NNP
en-wikipedia-org-4107	298	33	]	]	-RRB-
en-wikipedia-org-4107	298	34	Australia	Australia	NNP
en-wikipedia-org-4107	298	35	(	(	-LRB-
en-wikipedia-org-4107	298	36	schedule	schedule	NN
en-wikipedia-org-4107	298	37	 	  	_SP
en-wikipedia-org-4107	298	38	8),[247	8),[247	CD
en-wikipedia-org-4107	298	39	]	]	-RRB-
en-wikipedia-org-4107	298	40	Thailand	Thailand	NNP
en-wikipedia-org-4107	298	41	(	(	-LRB-
en-wikipedia-org-4107	298	42	category	category	NN
en-wikipedia-org-4107	298	43	 	  	_SP
en-wikipedia-org-4107	298	44	1	1	CD
en-wikipedia-org-4107	298	45	narcotic),[248	narcotic),[248	NN
en-wikipedia-org-4107	298	46	]	]	-RRB-
en-wikipedia-org-4107	298	47	and	and	CC
en-wikipedia-org-4107	298	48	United	United	NNP
en-wikipedia-org-4107	298	49	Kingdom	Kingdom	NNP
en-wikipedia-org-4107	298	50	(	(	-LRB-
en-wikipedia-org-4107	298	51	class	class	NN
en-wikipedia-org-4107	298	52	 	  	_SP
en-wikipedia-org-4107	298	53	B	b	NN
en-wikipedia-org-4107	298	54	drug),[249	drug),[249	NN
en-wikipedia-org-4107	298	55	]	]	-RRB-
en-wikipedia-org-4107	298	56	amphetamine	amphetamine	NN
en-wikipedia-org-4107	298	57	is	be	VBZ
en-wikipedia-org-4107	298	58	in	in	IN
en-wikipedia-org-4107	298	59	a	a	DT
en-wikipedia-org-4107	298	60	restrictive	restrictive	JJ
en-wikipedia-org-4107	298	61	national	national	JJ
en-wikipedia-org-4107	298	62	drug	drug	NN
en-wikipedia-org-4107	298	63	schedule	schedule	NN
en-wikipedia-org-4107	298	64	that	that	WDT
en-wikipedia-org-4107	298	65	allows	allow	VBZ
en-wikipedia-org-4107	298	66	for	for	IN
en-wikipedia-org-4107	298	67	its	-PRON-	PRP$
en-wikipedia-org-4107	298	68	use	use	NN
en-wikipedia-org-4107	298	69	as	as	IN
en-wikipedia-org-4107	298	70	a	a	DT
en-wikipedia-org-4107	298	71	medical	medical	JJ
en-wikipedia-org-4107	298	72	treatment	treatment	NN
en-wikipedia-org-4107	298	73	.	.	.
en-wikipedia-org-4107	299	1	[	[	-LRB-
en-wikipedia-org-4107	299	2	238][31	238][31	CD
en-wikipedia-org-4107	299	3	]	]	-RRB-
en-wikipedia-org-4107	299	4	Pharmaceutical	pharmaceutical	JJ
en-wikipedia-org-4107	299	5	products	product	NNS
en-wikipedia-org-4107	299	6	Several	several	JJ
en-wikipedia-org-4107	299	7	currently	currently	RB
en-wikipedia-org-4107	299	8	marketed	market	VBN
en-wikipedia-org-4107	299	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	299	10	formulations	formulation	NNS
en-wikipedia-org-4107	299	11	contain	contain	VBP
en-wikipedia-org-4107	299	12	both	both	DT
en-wikipedia-org-4107	299	13	enantiomers	enantiomer	NNS
en-wikipedia-org-4107	299	14	,	,	,
en-wikipedia-org-4107	299	15	including	include	VBG
en-wikipedia-org-4107	299	16	those	those	DT
en-wikipedia-org-4107	299	17	marketed	market	VBN
en-wikipedia-org-4107	299	18	under	under	IN
en-wikipedia-org-4107	299	19	the	the	DT
en-wikipedia-org-4107	299	20	brand	brand	NN
en-wikipedia-org-4107	299	21	names	name	NNS
en-wikipedia-org-4107	299	22	Adderall	Adderall	NNP
en-wikipedia-org-4107	299	23	,	,	,
en-wikipedia-org-4107	299	24	Adderall	Adderall	NNP
en-wikipedia-org-4107	299	25	 	  	_SP
en-wikipedia-org-4107	299	26	XR	XR	NNP
en-wikipedia-org-4107	299	27	,	,	,
en-wikipedia-org-4107	299	28	Mydayis,[note	Mydayis,[note	NNP
en-wikipedia-org-4107	299	29	1	1	LS
en-wikipedia-org-4107	299	30	]	]	-RRB-
en-wikipedia-org-4107	299	31	Adzenys	adzenys	NN
en-wikipedia-org-4107	299	32	 	  	_SP
en-wikipedia-org-4107	299	33	ER	ER	NNP
en-wikipedia-org-4107	299	34	,	,	,
en-wikipedia-org-4107	299	35	Adzenys	Adzenys	NNP
en-wikipedia-org-4107	299	36	XR	XR	NNP
en-wikipedia-org-4107	299	37	-	-	HYPH
en-wikipedia-org-4107	299	38	ODT	ODT	NNP
en-wikipedia-org-4107	299	39	,	,	,
en-wikipedia-org-4107	299	40	Dyanavel	Dyanavel	NNP
en-wikipedia-org-4107	299	41	 	  	_SP
en-wikipedia-org-4107	299	42	XR	XR	NNP
en-wikipedia-org-4107	299	43	,	,	,
en-wikipedia-org-4107	299	44	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	299	45	,	,	,
en-wikipedia-org-4107	299	46	and	and	CC
en-wikipedia-org-4107	299	47	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	299	48	 	  	_SP
en-wikipedia-org-4107	299	49	ODT	ODT	NNP
en-wikipedia-org-4107	299	50	.	.	.
en-wikipedia-org-4107	300	1	Of	of	IN
en-wikipedia-org-4107	300	2	those	those	DT
en-wikipedia-org-4107	300	3	,	,	,
en-wikipedia-org-4107	300	4	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	300	5	(	(	-LRB-
en-wikipedia-org-4107	300	6	including	include	VBG
en-wikipedia-org-4107	300	7	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	300	8	 	  	_SP
en-wikipedia-org-4107	300	9	ODT	ODT	NNP
en-wikipedia-org-4107	300	10	)	)	-RRB-
en-wikipedia-org-4107	300	11	is	be	VBZ
en-wikipedia-org-4107	300	12	the	the	DT
en-wikipedia-org-4107	300	13	only	only	JJ
en-wikipedia-org-4107	300	14	product	product	NN
en-wikipedia-org-4107	300	15	containing	contain	VBG
en-wikipedia-org-4107	300	16	only	only	JJ
en-wikipedia-org-4107	300	17	racemic	racemic	JJ
en-wikipedia-org-4107	300	18	amphetamine	amphetamine	NN
en-wikipedia-org-4107	300	19	(	(	-LRB-
en-wikipedia-org-4107	300	20	as	as	IN
en-wikipedia-org-4107	300	21	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	300	22	sulfate	sulfate	NNP
en-wikipedia-org-4107	300	23	)	)	-RRB-
en-wikipedia-org-4107	300	24	,	,	,
en-wikipedia-org-4107	300	25	and	and	CC
en-wikipedia-org-4107	300	26	is	be	VBZ
en-wikipedia-org-4107	300	27	therefore	therefore	RB
en-wikipedia-org-4107	300	28	the	the	DT
en-wikipedia-org-4107	300	29	only	only	JJ
en-wikipedia-org-4107	300	30	one	one	CD
en-wikipedia-org-4107	300	31	whose	whose	WP$
en-wikipedia-org-4107	300	32	active	active	JJ
en-wikipedia-org-4107	300	33	moiety	moiety	NN
en-wikipedia-org-4107	300	34	can	can	MD
en-wikipedia-org-4107	300	35	be	be	VB
en-wikipedia-org-4107	300	36	accurately	accurately	RB
en-wikipedia-org-4107	300	37	referred	refer	VBN
en-wikipedia-org-4107	300	38	to	to	TO
en-wikipedia-org-4107	300	39	simply	simply	RB
en-wikipedia-org-4107	300	40	as	as	IN
en-wikipedia-org-4107	300	41	"	"	``
en-wikipedia-org-4107	300	42	amphetamine	amphetamine	NN
en-wikipedia-org-4107	300	43	"	"	''
en-wikipedia-org-4107	300	44	.	.	.
en-wikipedia-org-4107	301	1	[	[	-LRB-
en-wikipedia-org-4107	301	2	2][35][88	2][35][88	LS
en-wikipedia-org-4107	301	3	]	]	-RRB-
en-wikipedia-org-4107	301	4	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	301	5	,	,	,
en-wikipedia-org-4107	301	6	marketed	market	VBN
en-wikipedia-org-4107	301	7	under	under	IN
en-wikipedia-org-4107	301	8	the	the	DT
en-wikipedia-org-4107	301	9	brand	brand	NN
en-wikipedia-org-4107	301	10	names	name	NNS
en-wikipedia-org-4107	301	11	Dexedrine	Dexedrine	NNP
en-wikipedia-org-4107	301	12	and	and	CC
en-wikipedia-org-4107	301	13	Zenzedi	Zenzedi	NNP
en-wikipedia-org-4107	301	14	,	,	,
en-wikipedia-org-4107	301	15	is	be	VBZ
en-wikipedia-org-4107	301	16	the	the	DT
en-wikipedia-org-4107	301	17	only	only	JJ
en-wikipedia-org-4107	301	18	enantiopure	enantiopure	NN
en-wikipedia-org-4107	301	19	amphetamine	amphetamine	NN
en-wikipedia-org-4107	301	20	product	product	NN
en-wikipedia-org-4107	301	21	currently	currently	RB
en-wikipedia-org-4107	301	22	available	available	JJ
en-wikipedia-org-4107	301	23	.	.	.
en-wikipedia-org-4107	302	1	A	a	DT
en-wikipedia-org-4107	302	2	prodrug	prodrug	NN
en-wikipedia-org-4107	302	3	form	form	NN
en-wikipedia-org-4107	302	4	of	of	IN
en-wikipedia-org-4107	302	5	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	302	6	,	,	,
en-wikipedia-org-4107	302	7	lisdexamfetamine	lisdexamfetamine	NN
en-wikipedia-org-4107	302	8	,	,	,
en-wikipedia-org-4107	302	9	is	be	VBZ
en-wikipedia-org-4107	302	10	also	also	RB
en-wikipedia-org-4107	302	11	available	available	JJ
en-wikipedia-org-4107	302	12	and	and	CC
en-wikipedia-org-4107	302	13	is	be	VBZ
en-wikipedia-org-4107	302	14	marketed	market	VBN
en-wikipedia-org-4107	302	15	under	under	IN
en-wikipedia-org-4107	302	16	the	the	DT
en-wikipedia-org-4107	302	17	brand	brand	NN
en-wikipedia-org-4107	302	18	name	name	NN
en-wikipedia-org-4107	302	19	Vyvanse	vyvanse	NN
en-wikipedia-org-4107	302	20	.	.	.
en-wikipedia-org-4107	303	1	As	as	IN
en-wikipedia-org-4107	303	2	it	-PRON-	PRP
en-wikipedia-org-4107	303	3	is	be	VBZ
en-wikipedia-org-4107	303	4	a	a	DT
en-wikipedia-org-4107	303	5	prodrug	prodrug	NN
en-wikipedia-org-4107	303	6	,	,	,
en-wikipedia-org-4107	303	7	lisdexamfetamine	lisdexamfetamine	NN
en-wikipedia-org-4107	303	8	is	be	VBZ
en-wikipedia-org-4107	303	9	structurally	structurally	RB
en-wikipedia-org-4107	303	10	different	different	JJ
en-wikipedia-org-4107	303	11	from	from	IN
en-wikipedia-org-4107	303	12	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	303	13	,	,	,
en-wikipedia-org-4107	303	14	and	and	CC
en-wikipedia-org-4107	303	15	is	be	VBZ
en-wikipedia-org-4107	303	16	inactive	inactive	JJ
en-wikipedia-org-4107	303	17	until	until	IN
en-wikipedia-org-4107	303	18	it	-PRON-	PRP
en-wikipedia-org-4107	303	19	metabolizes	metabolize	VBZ
en-wikipedia-org-4107	303	20	into	into	IN
en-wikipedia-org-4107	303	21	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	303	22	.	.	.
en-wikipedia-org-4107	304	1	[	[	-LRB-
en-wikipedia-org-4107	304	2	36][182	36][182	NNS
en-wikipedia-org-4107	304	3	]	]	-RRB-
en-wikipedia-org-4107	304	4	The	the	DT
en-wikipedia-org-4107	304	5	free	free	JJ
en-wikipedia-org-4107	304	6	base	base	NN
en-wikipedia-org-4107	304	7	of	of	IN
en-wikipedia-org-4107	304	8	racemic	racemic	JJ
en-wikipedia-org-4107	304	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	304	10	was	be	VBD
en-wikipedia-org-4107	304	11	previously	previously	RB
en-wikipedia-org-4107	304	12	available	available	JJ
en-wikipedia-org-4107	304	13	as	as	IN
en-wikipedia-org-4107	304	14	Benzedrine	Benzedrine	NNP
en-wikipedia-org-4107	304	15	,	,	,
en-wikipedia-org-4107	304	16	Psychedrine	Psychedrine	NNP
en-wikipedia-org-4107	304	17	,	,	,
en-wikipedia-org-4107	304	18	and	and	CC
en-wikipedia-org-4107	304	19	Sympatedrine	Sympatedrine	NNP
en-wikipedia-org-4107	304	20	.	.	.
en-wikipedia-org-4107	305	1	[	[	-LRB-
en-wikipedia-org-4107	305	2	3	3	LS
en-wikipedia-org-4107	305	3	]	]	-RRB-
en-wikipedia-org-4107	305	4	Levoamphetamine	Levoamphetamine	NNP
en-wikipedia-org-4107	305	5	was	be	VBD
en-wikipedia-org-4107	305	6	previously	previously	RB
en-wikipedia-org-4107	305	7	available	available	JJ
en-wikipedia-org-4107	305	8	as	as	IN
en-wikipedia-org-4107	305	9	Cydril	Cydril	NNP
en-wikipedia-org-4107	305	10	.	.	.
en-wikipedia-org-4107	306	1	[	[	-LRB-
en-wikipedia-org-4107	306	2	3	3	LS
en-wikipedia-org-4107	306	3	]	]	-RRB-
en-wikipedia-org-4107	306	4	Many	many	JJ
en-wikipedia-org-4107	306	5	current	current	JJ
en-wikipedia-org-4107	306	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	306	7	pharmaceuticals	pharmaceutical	NNS
en-wikipedia-org-4107	306	8	are	be	VBP
en-wikipedia-org-4107	306	9	salts	salt	NNS
en-wikipedia-org-4107	306	10	due	due	JJ
en-wikipedia-org-4107	306	11	to	to	IN
en-wikipedia-org-4107	306	12	the	the	DT
en-wikipedia-org-4107	306	13	comparatively	comparatively	RB
en-wikipedia-org-4107	306	14	high	high	JJ
en-wikipedia-org-4107	306	15	volatility	volatility	NN
en-wikipedia-org-4107	306	16	of	of	IN
en-wikipedia-org-4107	306	17	the	the	DT
en-wikipedia-org-4107	306	18	free	free	JJ
en-wikipedia-org-4107	306	19	base	base	NN
en-wikipedia-org-4107	306	20	.	.	.
en-wikipedia-org-4107	307	1	[	[	-LRB-
en-wikipedia-org-4107	307	2	3][36][47	3][36][47	CD
en-wikipedia-org-4107	307	3	]	]	-RRB-
en-wikipedia-org-4107	307	4	However	however	RB
en-wikipedia-org-4107	307	5	,	,	,
en-wikipedia-org-4107	307	6	oral	oral	JJ
en-wikipedia-org-4107	307	7	suspension	suspension	NN
en-wikipedia-org-4107	307	8	and	and	CC
en-wikipedia-org-4107	307	9	orally	orally	RB
en-wikipedia-org-4107	307	10	disintegrating	disintegrate	VBG
en-wikipedia-org-4107	307	11	tablet	tablet	NN
en-wikipedia-org-4107	307	12	(	(	-LRB-
en-wikipedia-org-4107	307	13	ODT	ODT	NNP
en-wikipedia-org-4107	307	14	)	)	-RRB-
en-wikipedia-org-4107	307	15	dosage	dosage	NN
en-wikipedia-org-4107	307	16	forms	form	NNS
en-wikipedia-org-4107	307	17	composed	compose	VBN
en-wikipedia-org-4107	307	18	of	of	IN
en-wikipedia-org-4107	307	19	the	the	DT
en-wikipedia-org-4107	307	20	free	free	JJ
en-wikipedia-org-4107	307	21	base	base	NN
en-wikipedia-org-4107	307	22	were	be	VBD
en-wikipedia-org-4107	307	23	introduced	introduce	VBN
en-wikipedia-org-4107	307	24	in	in	IN
en-wikipedia-org-4107	307	25	2015	2015	CD
en-wikipedia-org-4107	307	26	and	and	CC
en-wikipedia-org-4107	307	27	2016	2016	CD
en-wikipedia-org-4107	307	28	,	,	,
en-wikipedia-org-4107	307	29	respectively	respectively	RB
en-wikipedia-org-4107	307	30	.	.	.
en-wikipedia-org-4107	308	1	[	[	-LRB-
en-wikipedia-org-4107	308	2	88][250][251	88][250][251	NNP
en-wikipedia-org-4107	308	3	]	]	-RRB-
en-wikipedia-org-4107	308	4	Some	some	DT
en-wikipedia-org-4107	308	5	of	of	IN
en-wikipedia-org-4107	308	6	the	the	DT
en-wikipedia-org-4107	308	7	current	current	JJ
en-wikipedia-org-4107	308	8	brands	brand	NNS
en-wikipedia-org-4107	308	9	and	and	CC
en-wikipedia-org-4107	308	10	their	-PRON-	PRP$
en-wikipedia-org-4107	308	11	generic	generic	JJ
en-wikipedia-org-4107	308	12	equivalents	equivalent	NNS
en-wikipedia-org-4107	308	13	are	be	VBP
en-wikipedia-org-4107	308	14	listed	list	VBN
en-wikipedia-org-4107	308	15	below	below	RB
en-wikipedia-org-4107	308	16	.	.	.
en-wikipedia-org-4107	309	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	309	2	pharmaceuticals	pharmaceutical	NNS
en-wikipedia-org-4107	309	3	Brand	Brand	NNP
en-wikipedia-org-4107	309	4	name	name	NN
en-wikipedia-org-4107	309	5	United	United	NNP
en-wikipedia-org-4107	309	6	 	  	_SP
en-wikipedia-org-4107	309	7	States	States	NNP
en-wikipedia-org-4107	309	8	Adopted	Adopted	NNP
en-wikipedia-org-4107	309	9	 	  	_SP
en-wikipedia-org-4107	309	10	Name	name	NN
en-wikipedia-org-4107	309	11	(	(	-LRB-
en-wikipedia-org-4107	309	12	D	D	NNP
en-wikipedia-org-4107	309	13	:	:	:
en-wikipedia-org-4107	309	14	L	l	NN
en-wikipedia-org-4107	309	15	)	)	-RRB-
en-wikipedia-org-4107	309	16	 	  	_SP
en-wikipedia-org-4107	309	17	ratio	ratio	NN
en-wikipedia-org-4107	309	18	Dosage	dosage	NN
en-wikipedia-org-4107	309	19	form	form	NN
en-wikipedia-org-4107	309	20	Marketing	marketing	NN
en-wikipedia-org-4107	309	21	start	start	NN
en-wikipedia-org-4107	309	22	 	  	_SP
en-wikipedia-org-4107	309	23	date	date	NN
en-wikipedia-org-4107	309	24	US	US	NNP
en-wikipedia-org-4107	309	25	consumer	consumer	NN
en-wikipedia-org-4107	309	26	price	price	NN
en-wikipedia-org-4107	309	27	data	datum	NNS
en-wikipedia-org-4107	309	28	Sources	Sources	NNPS
en-wikipedia-org-4107	309	29	Adderall	Adderall	NNP
en-wikipedia-org-4107	309	30	–	–	:
en-wikipedia-org-4107	309	31	3:1	3:1	CD
en-wikipedia-org-4107	309	32	 	  	_SP
en-wikipedia-org-4107	309	33	(	(	-LRB-
en-wikipedia-org-4107	309	34	salts	salts	NNP
en-wikipedia-org-4107	309	35	)	)	-RRB-
en-wikipedia-org-4107	309	36	tablet	tablet	VB
en-wikipedia-org-4107	309	37	1996	1996	CD
en-wikipedia-org-4107	309	38	GoodRx	GoodRx	NNP
en-wikipedia-org-4107	309	39	[	[	-LRB-
en-wikipedia-org-4107	309	40	3][36	3][36	CD
en-wikipedia-org-4107	309	41	]	]	-RRB-
en-wikipedia-org-4107	309	42	Adderall	Adderall	NNP
en-wikipedia-org-4107	309	43	 	  	_SP
en-wikipedia-org-4107	309	44	XR	XR	NNP
en-wikipedia-org-4107	309	45	–	–	:
en-wikipedia-org-4107	309	46	3:1	3:1	ADD
en-wikipedia-org-4107	309	47	 	  	_SP
en-wikipedia-org-4107	309	48	(	(	-LRB-
en-wikipedia-org-4107	309	49	salts	salts	NNP
en-wikipedia-org-4107	309	50	)	)	-RRB-
en-wikipedia-org-4107	309	51	capsule	capsule	VBP
en-wikipedia-org-4107	309	52	2001	2001	CD
en-wikipedia-org-4107	309	53	GoodRx	goodrx	NN
en-wikipedia-org-4107	309	54	[	[	-LRB-
en-wikipedia-org-4107	309	55	3][36	3][36	CD
en-wikipedia-org-4107	309	56	]	]	-RRB-
en-wikipedia-org-4107	309	57	Mydayis	Mydayis	NNP
en-wikipedia-org-4107	309	58	–	–	:
en-wikipedia-org-4107	309	59	3:1	3:1	ADD
en-wikipedia-org-4107	309	60	 	  	_SP
en-wikipedia-org-4107	309	61	(	(	-LRB-
en-wikipedia-org-4107	309	62	salts	salts	NNP
en-wikipedia-org-4107	309	63	)	)	-RRB-
en-wikipedia-org-4107	309	64	capsule	capsule	VBP
en-wikipedia-org-4107	309	65	2017	2017	CD
en-wikipedia-org-4107	309	66	GoodRx	GoodRx	NNP
en-wikipedia-org-4107	309	67	[	[	-LRB-
en-wikipedia-org-4107	309	68	252][253	252][253	LS
en-wikipedia-org-4107	309	69	]	]	-RRB-
en-wikipedia-org-4107	309	70	Adzenys	adzenys	NN
en-wikipedia-org-4107	309	71	 	  	_SP
en-wikipedia-org-4107	309	72	ER	ER	NNP
en-wikipedia-org-4107	309	73	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	74	3:1	3:1	CD
en-wikipedia-org-4107	309	75	 	  	_SP
en-wikipedia-org-4107	309	76	(	(	-LRB-
en-wikipedia-org-4107	309	77	base	base	NN
en-wikipedia-org-4107	309	78	)	)	-RRB-
en-wikipedia-org-4107	309	79	suspension	suspension	NN
en-wikipedia-org-4107	309	80	2017	2017	CD
en-wikipedia-org-4107	309	81	GoodRx	GoodRx	NNP
en-wikipedia-org-4107	309	82	[	[	-LRB-
en-wikipedia-org-4107	309	83	254	254	CD
en-wikipedia-org-4107	309	84	]	]	-RRB-
en-wikipedia-org-4107	309	85	Adzenys	Adzenys	NNP
en-wikipedia-org-4107	309	86	XR	XR	NNP
en-wikipedia-org-4107	309	87	-	-	HYPH
en-wikipedia-org-4107	309	88	ODT	ODT	NNP
en-wikipedia-org-4107	309	89	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	90	3:1	3:1	CD
en-wikipedia-org-4107	309	91	 	  	_SP
en-wikipedia-org-4107	309	92	(	(	-LRB-
en-wikipedia-org-4107	309	93	base	base	NN
en-wikipedia-org-4107	309	94	)	)	-RRB-
en-wikipedia-org-4107	309	95	ODT	ODT	NNP
en-wikipedia-org-4107	309	96	2016	2016	CD
en-wikipedia-org-4107	309	97	GoodRx	goodrx	NN
en-wikipedia-org-4107	309	98	[	[	-LRB-
en-wikipedia-org-4107	309	99	251][255	251][255	CD
en-wikipedia-org-4107	309	100	]	]	-RRB-
en-wikipedia-org-4107	309	101	Dyanavel	Dyanavel	NNP
en-wikipedia-org-4107	309	102	 	  	_SP
en-wikipedia-org-4107	309	103	XR	XR	NNP
en-wikipedia-org-4107	309	104	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	105	3.2:1	3.2:1	NNP
en-wikipedia-org-4107	309	106	 	  	_SP
en-wikipedia-org-4107	309	107	(	(	-LRB-
en-wikipedia-org-4107	309	108	base	base	NN
en-wikipedia-org-4107	309	109	)	)	-RRB-
en-wikipedia-org-4107	309	110	suspension	suspension	NN
en-wikipedia-org-4107	309	111	2015	2015	CD
en-wikipedia-org-4107	309	112	GoodRx	goodrx	NN
en-wikipedia-org-4107	309	113	[	[	-LRB-
en-wikipedia-org-4107	309	114	88][250	88][250	NNP
en-wikipedia-org-4107	309	115	]	]	-RRB-
en-wikipedia-org-4107	309	116	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	309	117	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	118	 	  	_SP
en-wikipedia-org-4107	309	119	sulfate	sulfate	VBP
en-wikipedia-org-4107	309	120	1:1	1:1	CD
en-wikipedia-org-4107	309	121	 	  	_SP
en-wikipedia-org-4107	309	122	(	(	-LRB-
en-wikipedia-org-4107	309	123	salts	salts	NNP
en-wikipedia-org-4107	309	124	)	)	-RRB-
en-wikipedia-org-4107	309	125	tablet	tablet	NN
en-wikipedia-org-4107	309	126	2012	2012	CD
en-wikipedia-org-4107	309	127	GoodRx	GoodRx	NNP
en-wikipedia-org-4107	309	128	[	[	-LRB-
en-wikipedia-org-4107	309	129	35][256	35][256	NNP
en-wikipedia-org-4107	309	130	]	]	-RRB-
en-wikipedia-org-4107	309	131	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	309	132	 	  	_SP
en-wikipedia-org-4107	309	133	ODT	ODT	NNP
en-wikipedia-org-4107	309	134	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	135	 	  	_SP
en-wikipedia-org-4107	309	136	sulfate	sulfate	VBP
en-wikipedia-org-4107	309	137	1:1	1:1	CD
en-wikipedia-org-4107	309	138	 	  	_SP
en-wikipedia-org-4107	309	139	(	(	-LRB-
en-wikipedia-org-4107	309	140	salts	salt	NNS
en-wikipedia-org-4107	309	141	)	)	-RRB-
en-wikipedia-org-4107	309	142	ODT	ODT	NNP
en-wikipedia-org-4107	309	143	2019	2019	CD
en-wikipedia-org-4107	309	144	GoodRx	goodrx	CD
en-wikipedia-org-4107	309	145	[	[	-LRB-
en-wikipedia-org-4107	309	146	257	257	CD
en-wikipedia-org-4107	309	147	]	]	-RRB-
en-wikipedia-org-4107	309	148	Dexedrine	Dexedrine	NNP
en-wikipedia-org-4107	309	149	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	309	150	 	  	_SP
en-wikipedia-org-4107	309	151	sulfate	sulfate	VBP
en-wikipedia-org-4107	309	152	1:0	1:0	CD
en-wikipedia-org-4107	309	153	 	  	_SP
en-wikipedia-org-4107	309	154	(	(	-LRB-
en-wikipedia-org-4107	309	155	salts	salts	NNP
en-wikipedia-org-4107	309	156	)	)	-RRB-
en-wikipedia-org-4107	309	157	capsule	capsule	VBP
en-wikipedia-org-4107	309	158	1976	1976	CD
en-wikipedia-org-4107	309	159	GoodRx	GoodRx	NNP
en-wikipedia-org-4107	309	160	[	[	-LRB-
en-wikipedia-org-4107	309	161	3][36	3][36	CD
en-wikipedia-org-4107	309	162	]	]	-RRB-
en-wikipedia-org-4107	309	163	Zenzedi	Zenzedi	NNP
en-wikipedia-org-4107	309	164	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	309	165	 	  	_SP
en-wikipedia-org-4107	309	166	sulfate	sulfate	VBP
en-wikipedia-org-4107	309	167	1:0	1:0	CD
en-wikipedia-org-4107	309	168	 	  	_SP
en-wikipedia-org-4107	309	169	(	(	-LRB-
en-wikipedia-org-4107	309	170	salts	salts	NNP
en-wikipedia-org-4107	309	171	)	)	-RRB-
en-wikipedia-org-4107	309	172	tablet	tablet	VB
en-wikipedia-org-4107	309	173	2013	2013	CD
en-wikipedia-org-4107	309	174	GoodRx	GoodRx	NNP
en-wikipedia-org-4107	309	175	[	[	-LRB-
en-wikipedia-org-4107	309	176	36][258	36][258	NNP
en-wikipedia-org-4107	309	177	]	]	-RRB-
en-wikipedia-org-4107	309	178	Vyvanse	vyvanse	NN
en-wikipedia-org-4107	309	179	lisdexamfetamine	lisdexamfetamine	NN
en-wikipedia-org-4107	309	180	 	  	_SP
en-wikipedia-org-4107	309	181	dimesylate	dimesylate	VB
en-wikipedia-org-4107	309	182	1:0	1:0	CD
en-wikipedia-org-4107	309	183	 	  	_SP
en-wikipedia-org-4107	309	184	(	(	-LRB-
en-wikipedia-org-4107	309	185	prodrug	prodrug	NN
en-wikipedia-org-4107	309	186	)	)	-RRB-
en-wikipedia-org-4107	309	187	capsule	capsule	VBP
en-wikipedia-org-4107	309	188	2007	2007	CD
en-wikipedia-org-4107	309	189	GoodRx	GoodRx	NNP
en-wikipedia-org-4107	309	190	[	[	-LRB-
en-wikipedia-org-4107	309	191	3][182][259	3][182][259	CD
en-wikipedia-org-4107	309	192	]	]	-RRB-
en-wikipedia-org-4107	309	193	tablet	tablet	NN
en-wikipedia-org-4107	309	194	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	309	195	base	base	NN
en-wikipedia-org-4107	309	196	in	in	IN
en-wikipedia-org-4107	309	197	marketed	marketed	JJ
en-wikipedia-org-4107	309	198	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	199	medications	medication	NNS
en-wikipedia-org-4107	309	200	drug	drug	NNP
en-wikipedia-org-4107	309	201	formula	formula	NNP
en-wikipedia-org-4107	309	202	molecular	molecular	JJ
en-wikipedia-org-4107	309	203	mass	mass	NN
en-wikipedia-org-4107	309	204	[	[	-LRB-
en-wikipedia-org-4107	309	205	note	note	NN
en-wikipedia-org-4107	309	206	21	21	CD
en-wikipedia-org-4107	309	207	]	]	-RRB-
en-wikipedia-org-4107	309	208	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	209	base	base	NN
en-wikipedia-org-4107	309	210	[	[	-LRB-
en-wikipedia-org-4107	309	211	note	note	NN
en-wikipedia-org-4107	309	212	22	22	CD
en-wikipedia-org-4107	309	213	]	]	-RRB-
en-wikipedia-org-4107	309	214	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	215	base	base	NN
en-wikipedia-org-4107	309	216	in	in	IN
en-wikipedia-org-4107	309	217	equal	equal	JJ
en-wikipedia-org-4107	309	218	doses	dose	NNS
en-wikipedia-org-4107	309	219	doses	dose	NNS
en-wikipedia-org-4107	309	220	with	with	IN
en-wikipedia-org-4107	309	221	equal	equal	JJ
en-wikipedia-org-4107	309	222	base	base	NN
en-wikipedia-org-4107	309	223	content	content	NN
en-wikipedia-org-4107	309	224	[	[	-LRB-
en-wikipedia-org-4107	309	225	note	note	VBP
en-wikipedia-org-4107	309	226	23	23	CD
en-wikipedia-org-4107	309	227	]	]	-RRB-
en-wikipedia-org-4107	309	228	(	(	-LRB-
en-wikipedia-org-4107	309	229	g	g	NNP
en-wikipedia-org-4107	309	230	/	/	SYM
en-wikipedia-org-4107	309	231	mol	mol	NN
en-wikipedia-org-4107	309	232	)	)	-RRB-
en-wikipedia-org-4107	309	233	(	(	-LRB-
en-wikipedia-org-4107	309	234	percent	percent	NN
en-wikipedia-org-4107	309	235	)	)	-RRB-
en-wikipedia-org-4107	309	236	(	(	-LRB-
en-wikipedia-org-4107	309	237	30	30	CD
en-wikipedia-org-4107	309	238	 	  	_SP
en-wikipedia-org-4107	309	239	mg	mg	NNP
en-wikipedia-org-4107	309	240	dose	dose	VB
en-wikipedia-org-4107	309	241	)	)	-RRB-
en-wikipedia-org-4107	309	242	total	total	JJ
en-wikipedia-org-4107	309	243	base	base	NN
en-wikipedia-org-4107	309	244	total	total	NN
en-wikipedia-org-4107	309	245	dextro-	dextro-	XX
en-wikipedia-org-4107	309	246	levo-	levo-	NNP
en-wikipedia-org-4107	309	247	dextro-	dextro-	NNP
en-wikipedia-org-4107	309	248	levo-	levo-	NNP
en-wikipedia-org-4107	309	249	dextroamphetamine	dextroamphetamine	NNP
en-wikipedia-org-4107	309	250	sulfate[261][262	sulfate[261][262	NNP
en-wikipedia-org-4107	309	251	]	]	-RRB-
en-wikipedia-org-4107	309	252	(	(	-LRB-
en-wikipedia-org-4107	309	253	C9H13N)2•H2SO4	c9h13n)2•h2so4	UH
en-wikipedia-org-4107	309	254	368.49	368.49	CD
en-wikipedia-org-4107	309	255	270.41	270.41	CD
en-wikipedia-org-4107	309	256	73.38	73.38	CD
en-wikipedia-org-4107	309	257	%	%	NN
en-wikipedia-org-4107	309	258	73.38	73.38	CD
en-wikipedia-org-4107	309	259	%	%	NN
en-wikipedia-org-4107	309	260	—	—	:
en-wikipedia-org-4107	309	261	22.0	22.0	CD
en-wikipedia-org-4107	309	262	 	  	_SP
en-wikipedia-org-4107	309	263	mg	mg	NNP
en-wikipedia-org-4107	309	264	—	—	:
en-wikipedia-org-4107	309	265	30.0	30.0	CD
en-wikipedia-org-4107	309	266	 	  	_SP
en-wikipedia-org-4107	309	267	mg	mg	NNP
en-wikipedia-org-4107	309	268	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	309	269	sulfate[263	sulfate[263	FW
en-wikipedia-org-4107	309	270	]	]	-RRB-
en-wikipedia-org-4107	309	271	(	(	-LRB-
en-wikipedia-org-4107	309	272	C9H13N)2•H2SO4	c9h13n)2•h2so4	UH
en-wikipedia-org-4107	309	273	368.49	368.49	CD
en-wikipedia-org-4107	309	274	270.41	270.41	CD
en-wikipedia-org-4107	309	275	73.38	73.38	CD
en-wikipedia-org-4107	309	276	%	%	NN
en-wikipedia-org-4107	309	277	36.69	36.69	CD
en-wikipedia-org-4107	309	278	%	%	NN
en-wikipedia-org-4107	309	279	36.69	36.69	CD
en-wikipedia-org-4107	309	280	%	%	NN
en-wikipedia-org-4107	309	281	11.0	11.0	CD
en-wikipedia-org-4107	309	282	 	  	_SP
en-wikipedia-org-4107	309	283	mg	mg	NNP
en-wikipedia-org-4107	309	284	11.0	11.0	CD
en-wikipedia-org-4107	309	285	 	  	_SP
en-wikipedia-org-4107	309	286	mg	mg	NNP
en-wikipedia-org-4107	309	287	30.0	30.0	CD
en-wikipedia-org-4107	309	288	 	  	_SP
en-wikipedia-org-4107	309	289	mg	mg	NNP
en-wikipedia-org-4107	309	290	Adderall	Adderall	NNP
en-wikipedia-org-4107	309	291	62.57	62.57	CD
en-wikipedia-org-4107	309	292	%	%	NN
en-wikipedia-org-4107	309	293	47.49	47.49	CD
en-wikipedia-org-4107	309	294	%	%	NN
en-wikipedia-org-4107	309	295	15.08	15.08	CD
en-wikipedia-org-4107	309	296	%	%	NN
en-wikipedia-org-4107	309	297	14.2	14.2	CD
en-wikipedia-org-4107	309	298	 	  	_SP
en-wikipedia-org-4107	309	299	mg	mg	NNP
en-wikipedia-org-4107	309	300	4.5	4.5	CD
en-wikipedia-org-4107	309	301	 	  	_SP
en-wikipedia-org-4107	309	302	mg	mg	NNP
en-wikipedia-org-4107	309	303	35.2	35.2	CD
en-wikipedia-org-4107	309	304	 	  	_SP
en-wikipedia-org-4107	309	305	mg	mg	NNP
en-wikipedia-org-4107	309	306	25	25	CD
en-wikipedia-org-4107	309	307	%	%	NN
en-wikipedia-org-4107	309	308	dextroamphetamine	dextroamphetamine	JJ
en-wikipedia-org-4107	309	309	sulfate[261][262	sulfate[261][262	NNP
en-wikipedia-org-4107	309	310	]	]	-RRB-
en-wikipedia-org-4107	309	311	(	(	-LRB-
en-wikipedia-org-4107	309	312	C9H13N)2•H2SO4	c9h13n)2•h2so4	UH
en-wikipedia-org-4107	309	313	368.49	368.49	CD
en-wikipedia-org-4107	309	314	270.41	270.41	CD
en-wikipedia-org-4107	309	315	73.38	73.38	CD
en-wikipedia-org-4107	309	316	%	%	NN
en-wikipedia-org-4107	309	317	73.38	73.38	CD
en-wikipedia-org-4107	309	318	%	%	NN
en-wikipedia-org-4107	309	319	—	—	:
en-wikipedia-org-4107	309	320	25	25	CD
en-wikipedia-org-4107	309	321	%	%	NN
en-wikipedia-org-4107	309	322	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	323	sulfate[263	sulfate[263	NN
en-wikipedia-org-4107	309	324	]	]	-RRB-
en-wikipedia-org-4107	309	325	(	(	-LRB-
en-wikipedia-org-4107	309	326	C9H13N)2•H2SO4	c9h13n)2•h2so4	UH
en-wikipedia-org-4107	309	327	368.49	368.49	CD
en-wikipedia-org-4107	309	328	270.41	270.41	CD
en-wikipedia-org-4107	309	329	73.38	73.38	CD
en-wikipedia-org-4107	309	330	%	%	NN
en-wikipedia-org-4107	309	331	36.69	36.69	CD
en-wikipedia-org-4107	309	332	%	%	NN
en-wikipedia-org-4107	309	333	36.69	36.69	CD
en-wikipedia-org-4107	309	334	%	%	NN
en-wikipedia-org-4107	309	335	25	25	CD
en-wikipedia-org-4107	309	336	%	%	NN
en-wikipedia-org-4107	309	337	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	309	338	saccharate[264	saccharate[264	NN
en-wikipedia-org-4107	309	339	]	]	-RRB-
en-wikipedia-org-4107	309	340	(	(	-LRB-
en-wikipedia-org-4107	309	341	C9H13N)2•C6H10O8	c9h13n)2•c6h10o8	$
en-wikipedia-org-4107	309	342	480.55	480.55	CD
en-wikipedia-org-4107	309	343	270.41	270.41	CD
en-wikipedia-org-4107	309	344	56.27	56.27	CD
en-wikipedia-org-4107	309	345	%	%	NN
en-wikipedia-org-4107	309	346	56.27	56.27	CD
en-wikipedia-org-4107	309	347	%	%	NN
en-wikipedia-org-4107	309	348	—	—	:
en-wikipedia-org-4107	309	349	25	25	CD
en-wikipedia-org-4107	309	350	%	%	NN
en-wikipedia-org-4107	309	351	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	352	aspartate	aspartate	NN
en-wikipedia-org-4107	309	353	monohydrate[265	monohydrate[265	NN
en-wikipedia-org-4107	309	354	]	]	-RRB-
en-wikipedia-org-4107	309	355	(	(	-LRB-
en-wikipedia-org-4107	309	356	C9H13N)•C4H7NO4•H2O	C9H13N)•C4H7NO4•H2O	NNP
en-wikipedia-org-4107	309	357	286.32	286.32	CD
en-wikipedia-org-4107	309	358	135.21	135.21	CD
en-wikipedia-org-4107	309	359	47.22	47.22	CD
en-wikipedia-org-4107	309	360	%	%	NN
en-wikipedia-org-4107	309	361	23.61	23.61	CD
en-wikipedia-org-4107	309	362	%	%	NN
en-wikipedia-org-4107	309	363	23.61	23.61	CD
en-wikipedia-org-4107	309	364	%	%	NN
en-wikipedia-org-4107	309	365	lisdexamfetamine	lisdexamfetamine	NN
en-wikipedia-org-4107	309	366	dimesylate[182	dimesylate[182	NNP
en-wikipedia-org-4107	309	367	]	]	-RRB-
en-wikipedia-org-4107	309	368	C15H25N3O•(CH4O3S)2	C15H25N3O•(CH4O3S)2	NNP
en-wikipedia-org-4107	309	369	455.49	455.49	CD
en-wikipedia-org-4107	309	370	135.21	135.21	CD
en-wikipedia-org-4107	309	371	29.68	29.68	CD
en-wikipedia-org-4107	309	372	%	%	NN
en-wikipedia-org-4107	309	373	29.68	29.68	CD
en-wikipedia-org-4107	309	374	%	%	NN
en-wikipedia-org-4107	309	375	—	—	:
en-wikipedia-org-4107	309	376	8.9	8.9	CD
en-wikipedia-org-4107	309	377	 	  	_SP
en-wikipedia-org-4107	309	378	mg	mg	NNP
en-wikipedia-org-4107	309	379	—	—	:
en-wikipedia-org-4107	309	380	74.2	74.2	CD
en-wikipedia-org-4107	309	381	 	  	_SP
en-wikipedia-org-4107	309	382	mg	mg	NNP
en-wikipedia-org-4107	309	383	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	309	384	base	base	NNP
en-wikipedia-org-4107	309	385	suspension[note	suspension[note	,
en-wikipedia-org-4107	309	386	24][88	24][88	CD
en-wikipedia-org-4107	309	387	]	]	-RRB-
en-wikipedia-org-4107	309	388	C9H13N	C9H13N	NNP
en-wikipedia-org-4107	309	389	135.21	135.21	CD
en-wikipedia-org-4107	309	390	135.21	135.21	CD
en-wikipedia-org-4107	309	391	100	100	CD
en-wikipedia-org-4107	309	392	%	%	NN
en-wikipedia-org-4107	309	393	76.19	76.19	CD
en-wikipedia-org-4107	309	394	%	%	NN
en-wikipedia-org-4107	309	395	23.81	23.81	CD
en-wikipedia-org-4107	309	396	%	%	NN
en-wikipedia-org-4107	309	397	22.9	22.9	CD
en-wikipedia-org-4107	309	398	 	  	_SP
en-wikipedia-org-4107	309	399	mg	mg	NNP
en-wikipedia-org-4107	309	400	7.1	7.1	CD
en-wikipedia-org-4107	309	401	 	  	_SP
en-wikipedia-org-4107	309	402	mg	mg	NNP
en-wikipedia-org-4107	309	403	22.0	22.0	CD
en-wikipedia-org-4107	309	404	 	  	_SP
en-wikipedia-org-4107	309	405	mg	mg	NNP
en-wikipedia-org-4107	309	406	Notes	Notes	NNPS
en-wikipedia-org-4107	309	407	^	^	VBP
en-wikipedia-org-4107	309	408	a	a	DT
en-wikipedia-org-4107	309	409	b	b	NN
en-wikipedia-org-4107	309	410	Adderall	Adderall	NNP
en-wikipedia-org-4107	309	411	and	and	CC
en-wikipedia-org-4107	309	412	other	other	JJ
en-wikipedia-org-4107	309	413	mixed	mixed	JJ
en-wikipedia-org-4107	309	414	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	415	salts	salt	NNS
en-wikipedia-org-4107	309	416	products	product	NNS
en-wikipedia-org-4107	309	417	such	such	JJ
en-wikipedia-org-4107	309	418	as	as	IN
en-wikipedia-org-4107	309	419	Mydayis	Mydayis	NNP
en-wikipedia-org-4107	309	420	are	be	VBP
en-wikipedia-org-4107	309	421	not	not	RB
en-wikipedia-org-4107	309	422	racemic	racemic	JJ
en-wikipedia-org-4107	309	423	amphetamine	amphetamine	NN
en-wikipedia-org-4107	309	424	-	-	:
en-wikipedia-org-4107	309	425	they	-PRON-	PRP
en-wikipedia-org-4107	309	426	are	be	VBP
en-wikipedia-org-4107	309	427	a	a	DT
en-wikipedia-org-4107	309	428	mixture	mixture	NN
en-wikipedia-org-4107	309	429	composed	compose	VBN
en-wikipedia-org-4107	309	430	of	of	IN
en-wikipedia-org-4107	309	431	equal	equal	JJ
en-wikipedia-org-4107	309	432	parts	part	NNS
en-wikipedia-org-4107	309	433	racemate	racemate	NN
en-wikipedia-org-4107	309	434	and	and	CC
en-wikipedia-org-4107	309	435	dextroamphetamine	dextroamphetamine	JJ
en-wikipedia-org-4107	309	436	.	.	.
en-wikipedia-org-4107	310	1	See	see	VB
en-wikipedia-org-4107	310	2	Mixed	mixed	JJ
en-wikipedia-org-4107	310	3	amphetamine	amphetamine	NN
en-wikipedia-org-4107	310	4	salts	salt	NNS
en-wikipedia-org-4107	310	5	for	for	IN
en-wikipedia-org-4107	310	6	more	more	JJR
en-wikipedia-org-4107	310	7	information	information	NN
en-wikipedia-org-4107	310	8	about	about	IN
en-wikipedia-org-4107	310	9	the	the	DT
en-wikipedia-org-4107	310	10	mixture	mixture	NN
en-wikipedia-org-4107	310	11	,	,	,
en-wikipedia-org-4107	310	12	and	and	CC
en-wikipedia-org-4107	310	13	this	this	DT
en-wikipedia-org-4107	310	14	section	section	NN
en-wikipedia-org-4107	310	15	for	for	IN
en-wikipedia-org-4107	310	16	information	information	NN
en-wikipedia-org-4107	310	17	about	about	IN
en-wikipedia-org-4107	310	18	the	the	DT
en-wikipedia-org-4107	310	19	various	various	JJ
en-wikipedia-org-4107	310	20	mixtures	mixture	NNS
en-wikipedia-org-4107	310	21	of	of	IN
en-wikipedia-org-4107	310	22	amphetamine	amphetamine	NN
en-wikipedia-org-4107	310	23	enantiomers	enantiomer	NNS
en-wikipedia-org-4107	310	24	currently	currently	RB
en-wikipedia-org-4107	310	25	marketed	market	VBD
en-wikipedia-org-4107	310	26	.	.	.
en-wikipedia-org-4107	311	1	^	^	NFP
en-wikipedia-org-4107	311	2	Synonyms	Synonyms	NNP
en-wikipedia-org-4107	311	3	and	and	CC
en-wikipedia-org-4107	311	4	alternate	alternate	JJ
en-wikipedia-org-4107	311	5	spellings	spelling	NNS
en-wikipedia-org-4107	311	6	include	include	VBP
en-wikipedia-org-4107	311	7	:	:	:
en-wikipedia-org-4107	311	8	1-phenylpropan-2-amine	1-phenylpropan-2-amine	CD
en-wikipedia-org-4107	311	9	(	(	-LRB-
en-wikipedia-org-4107	311	10	IUPAC	IUPAC	NNP
en-wikipedia-org-4107	311	11	name	name	NN
en-wikipedia-org-4107	311	12	)	)	-RRB-
en-wikipedia-org-4107	311	13	,	,	,
en-wikipedia-org-4107	311	14	α	α	NNP
en-wikipedia-org-4107	311	15	-	-	HYPH
en-wikipedia-org-4107	311	16	methylphenethylamine	methylphenethylamine	NN
en-wikipedia-org-4107	311	17	,	,	,
en-wikipedia-org-4107	311	18	amfetamine	amfetamine	NNP
en-wikipedia-org-4107	311	19	(	(	-LRB-
en-wikipedia-org-4107	311	20	International	International	NNP
en-wikipedia-org-4107	311	21	Nonproprietary	Nonproprietary	NNP
en-wikipedia-org-4107	311	22	Name	Name	NNP
en-wikipedia-org-4107	311	23	[	[	-LRB-
en-wikipedia-org-4107	311	24	INN	INN	NNP
en-wikipedia-org-4107	311	25	]	]	-RRB-
en-wikipedia-org-4107	311	26	)	)	-RRB-
en-wikipedia-org-4107	311	27	,	,	,
en-wikipedia-org-4107	311	28	β	β	NNP
en-wikipedia-org-4107	311	29	-	-	HYPH
en-wikipedia-org-4107	311	30	phenylisopropylamine	phenylisopropylamine	NNP
en-wikipedia-org-4107	311	31	,	,	,
en-wikipedia-org-4107	311	32	and	and	CC
en-wikipedia-org-4107	311	33	speed	speed	NN
en-wikipedia-org-4107	311	34	.	.	.
en-wikipedia-org-4107	312	1	[	[	-LRB-
en-wikipedia-org-4107	312	2	22][23][24	22][23][24	CD
en-wikipedia-org-4107	312	3	]	]	-RRB-
en-wikipedia-org-4107	312	4	^	^	NN
en-wikipedia-org-4107	312	5	Enantiomers	enantiomer	NNS
en-wikipedia-org-4107	312	6	are	be	VBP
en-wikipedia-org-4107	312	7	molecules	molecule	NNS
en-wikipedia-org-4107	312	8	that	that	WDT
en-wikipedia-org-4107	312	9	are	be	VBP
en-wikipedia-org-4107	312	10	mirror	mirror	NN
en-wikipedia-org-4107	312	11	images	image	NNS
en-wikipedia-org-4107	312	12	of	of	IN
en-wikipedia-org-4107	312	13	one	one	CD
en-wikipedia-org-4107	312	14	another	another	DT
en-wikipedia-org-4107	312	15	;	;	:
en-wikipedia-org-4107	312	16	they	-PRON-	PRP
en-wikipedia-org-4107	312	17	are	be	VBP
en-wikipedia-org-4107	312	18	structurally	structurally	RB
en-wikipedia-org-4107	312	19	identical	identical	JJ
en-wikipedia-org-4107	312	20	,	,	,
en-wikipedia-org-4107	312	21	but	but	CC
en-wikipedia-org-4107	312	22	of	of	IN
en-wikipedia-org-4107	312	23	the	the	DT
en-wikipedia-org-4107	312	24	opposite	opposite	JJ
en-wikipedia-org-4107	312	25	orientation	orientation	NN
en-wikipedia-org-4107	312	26	.	.	.
en-wikipedia-org-4107	313	1	[	[	-LRB-
en-wikipedia-org-4107	313	2	25	25	CD
en-wikipedia-org-4107	313	3	]	]	-RRB-
en-wikipedia-org-4107	313	4	Levoamphetamine	Levoamphetamine	NNP
en-wikipedia-org-4107	313	5	and	and	CC
en-wikipedia-org-4107	313	6	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	313	7	are	be	VBP
en-wikipedia-org-4107	313	8	also	also	RB
en-wikipedia-org-4107	313	9	known	know	VBN
en-wikipedia-org-4107	313	10	as	as	IN
en-wikipedia-org-4107	313	11	L	L	NNP
en-wikipedia-org-4107	313	12	-	-	HYPH
en-wikipedia-org-4107	313	13	amph	amph	NN
en-wikipedia-org-4107	313	14	or	or	CC
en-wikipedia-org-4107	313	15	levamfetamine	levamfetamine	NN
en-wikipedia-org-4107	313	16	(	(	-LRB-
en-wikipedia-org-4107	313	17	INN	INN	NNP
en-wikipedia-org-4107	313	18	)	)	-RRB-
en-wikipedia-org-4107	313	19	and	and	CC
en-wikipedia-org-4107	313	20	D	D	NNP
en-wikipedia-org-4107	313	21	-	-	HYPH
en-wikipedia-org-4107	313	22	amph	amph	NN
en-wikipedia-org-4107	313	23	or	or	CC
en-wikipedia-org-4107	313	24	dexamfetamine	dexamfetamine	NN
en-wikipedia-org-4107	313	25	(	(	-LRB-
en-wikipedia-org-4107	313	26	INN	INN	NNP
en-wikipedia-org-4107	313	27	)	)	-RRB-
en-wikipedia-org-4107	313	28	respectively	respectively	RB
en-wikipedia-org-4107	313	29	.	.	.
en-wikipedia-org-4107	314	1	[	[	-LRB-
en-wikipedia-org-4107	314	2	22	22	CD
en-wikipedia-org-4107	314	3	]	]	-RRB-
en-wikipedia-org-4107	314	4	^	^	.
en-wikipedia-org-4107	314	5	The	the	DT
en-wikipedia-org-4107	314	6	brand	brand	NN
en-wikipedia-org-4107	314	7	name	name	NN
en-wikipedia-org-4107	314	8	Adderall	Adderall	NNP
en-wikipedia-org-4107	314	9	is	be	VBZ
en-wikipedia-org-4107	314	10	used	use	VBN
en-wikipedia-org-4107	314	11	primarily	primarily	RB
en-wikipedia-org-4107	314	12	throughout	throughout	IN
en-wikipedia-org-4107	314	13	this	this	DT
en-wikipedia-org-4107	314	14	article	article	NN
en-wikipedia-org-4107	314	15	to	to	TO
en-wikipedia-org-4107	314	16	refer	refer	VB
en-wikipedia-org-4107	314	17	to	to	IN
en-wikipedia-org-4107	314	18	the	the	DT
en-wikipedia-org-4107	314	19	amphetamine	amphetamine	NN
en-wikipedia-org-4107	314	20	salt	salt	NN
en-wikipedia-org-4107	314	21	mixture	mixture	NN
en-wikipedia-org-4107	314	22	it	-PRON-	PRP
en-wikipedia-org-4107	314	23	contains	contain	VBZ
en-wikipedia-org-4107	314	24	because	because	IN
en-wikipedia-org-4107	314	25	the	the	DT
en-wikipedia-org-4107	314	26	four	four	CD
en-wikipedia-org-4107	314	27	-	-	HYPH
en-wikipedia-org-4107	314	28	salt	salt	NN
en-wikipedia-org-4107	314	29	composition	composition	NN
en-wikipedia-org-4107	314	30	of	of	IN
en-wikipedia-org-4107	314	31	the	the	DT
en-wikipedia-org-4107	314	32	drug	drug	NN
en-wikipedia-org-4107	314	33	makes	make	VBZ
en-wikipedia-org-4107	314	34	its	-PRON-	PRP$
en-wikipedia-org-4107	314	35	nonproprietary	nonproprietary	JJ
en-wikipedia-org-4107	314	36	name	name	NN
en-wikipedia-org-4107	314	37	(	(	-LRB-
en-wikipedia-org-4107	314	38	dextroamphetamine	dextroamphetamine	NNP
en-wikipedia-org-4107	314	39	sulfate	sulfate	NN
en-wikipedia-org-4107	314	40	25	25	CD
en-wikipedia-org-4107	314	41	%	%	NN
en-wikipedia-org-4107	314	42	,	,	,
en-wikipedia-org-4107	314	43	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	314	44	saccharate	saccharate	VBP
en-wikipedia-org-4107	314	45	25	25	CD
en-wikipedia-org-4107	314	46	%	%	NN
en-wikipedia-org-4107	314	47	,	,	,
en-wikipedia-org-4107	314	48	amphetamine	amphetamine	NN
en-wikipedia-org-4107	314	49	sulfate	sulfate	NN
en-wikipedia-org-4107	314	50	25	25	CD
en-wikipedia-org-4107	314	51	%	%	NN
en-wikipedia-org-4107	314	52	,	,	,
en-wikipedia-org-4107	314	53	and	and	CC
en-wikipedia-org-4107	314	54	amphetamine	amphetamine	VB
en-wikipedia-org-4107	314	55	aspartate	aspartate	NN
en-wikipedia-org-4107	314	56	25	25	CD
en-wikipedia-org-4107	314	57	%	%	NN
en-wikipedia-org-4107	314	58	)	)	-RRB-
en-wikipedia-org-4107	314	59	excessively	excessively	RB
en-wikipedia-org-4107	314	60	lengthy	lengthy	JJ
en-wikipedia-org-4107	314	61	.	.	.
en-wikipedia-org-4107	315	1	[	[	-LRB-
en-wikipedia-org-4107	315	2	36	36	CD
en-wikipedia-org-4107	315	3	]	]	-RRB-
en-wikipedia-org-4107	315	4	^	^	.
en-wikipedia-org-4107	315	5	The	the	DT
en-wikipedia-org-4107	315	6	term	term	NN
en-wikipedia-org-4107	315	7	"	"	``
en-wikipedia-org-4107	315	8	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	315	9	"	"	''
en-wikipedia-org-4107	315	10	also	also	RB
en-wikipedia-org-4107	315	11	refers	refer	VBZ
en-wikipedia-org-4107	315	12	to	to	IN
en-wikipedia-org-4107	315	13	a	a	DT
en-wikipedia-org-4107	315	14	chemical	chemical	NN
en-wikipedia-org-4107	315	15	class	class	NN
en-wikipedia-org-4107	315	16	,	,	,
en-wikipedia-org-4107	315	17	but	but	CC
en-wikipedia-org-4107	315	18	,	,	,
en-wikipedia-org-4107	315	19	unlike	unlike	IN
en-wikipedia-org-4107	315	20	the	the	DT
en-wikipedia-org-4107	315	21	class	class	NN
en-wikipedia-org-4107	315	22	of	of	IN
en-wikipedia-org-4107	315	23	substituted	substitute	VBN
en-wikipedia-org-4107	315	24	amphetamines,[14	amphetamines,[14	CD
en-wikipedia-org-4107	315	25	]	]	-RRB-
en-wikipedia-org-4107	315	26	the	the	DT
en-wikipedia-org-4107	315	27	"	"	``
en-wikipedia-org-4107	315	28	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	315	29	"	"	''
en-wikipedia-org-4107	315	30	class	class	NN
en-wikipedia-org-4107	315	31	does	do	VBZ
en-wikipedia-org-4107	315	32	not	not	RB
en-wikipedia-org-4107	315	33	have	have	VB
en-wikipedia-org-4107	315	34	a	a	DT
en-wikipedia-org-4107	315	35	standardized	standardized	JJ
en-wikipedia-org-4107	315	36	definition	definition	NN
en-wikipedia-org-4107	315	37	in	in	IN
en-wikipedia-org-4107	315	38	academic	academic	JJ
en-wikipedia-org-4107	315	39	literature	literature	NN
en-wikipedia-org-4107	315	40	.	.	.
en-wikipedia-org-4107	316	1	[	[	-LRB-
en-wikipedia-org-4107	316	2	18	18	CD
en-wikipedia-org-4107	316	3	]	]	-RRB-
en-wikipedia-org-4107	316	4	One	one	CD
en-wikipedia-org-4107	316	5	of	of	IN
en-wikipedia-org-4107	316	6	the	the	DT
en-wikipedia-org-4107	316	7	more	more	RBR
en-wikipedia-org-4107	316	8	restrictive	restrictive	JJ
en-wikipedia-org-4107	316	9	definitions	definition	NNS
en-wikipedia-org-4107	316	10	of	of	IN
en-wikipedia-org-4107	316	11	this	this	DT
en-wikipedia-org-4107	316	12	class	class	NN
en-wikipedia-org-4107	316	13	includes	include	VBZ
en-wikipedia-org-4107	316	14	only	only	RB
en-wikipedia-org-4107	316	15	the	the	DT
en-wikipedia-org-4107	316	16	racemate	racemate	NN
en-wikipedia-org-4107	316	17	and	and	CC
en-wikipedia-org-4107	316	18	enantiomers	enantiomer	NNS
en-wikipedia-org-4107	316	19	of	of	IN
en-wikipedia-org-4107	316	20	amphetamine	amphetamine	NN
en-wikipedia-org-4107	316	21	and	and	CC
en-wikipedia-org-4107	316	22	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	316	23	.	.	.
en-wikipedia-org-4107	317	1	[	[	-LRB-
en-wikipedia-org-4107	317	2	18	18	CD
en-wikipedia-org-4107	317	3	]	]	-RRB-
en-wikipedia-org-4107	317	4	The	the	DT
en-wikipedia-org-4107	317	5	most	most	RBS
en-wikipedia-org-4107	317	6	general	general	JJ
en-wikipedia-org-4107	317	7	definition	definition	NN
en-wikipedia-org-4107	317	8	of	of	IN
en-wikipedia-org-4107	317	9	the	the	DT
en-wikipedia-org-4107	317	10	class	class	NN
en-wikipedia-org-4107	317	11	encompasses	encompass	VBZ
en-wikipedia-org-4107	317	12	a	a	DT
en-wikipedia-org-4107	317	13	broad	broad	JJ
en-wikipedia-org-4107	317	14	range	range	NN
en-wikipedia-org-4107	317	15	of	of	IN
en-wikipedia-org-4107	317	16	pharmacologically	pharmacologically	RB
en-wikipedia-org-4107	317	17	and	and	CC
en-wikipedia-org-4107	317	18	structurally	structurally	RB
en-wikipedia-org-4107	317	19	related	relate	VBN
en-wikipedia-org-4107	317	20	compounds	compound	NNS
en-wikipedia-org-4107	317	21	.	.	.
en-wikipedia-org-4107	318	1	[	[	-LRB-
en-wikipedia-org-4107	318	2	18	18	CD
en-wikipedia-org-4107	318	3	]	]	-RRB-
en-wikipedia-org-4107	318	4	Due	due	IN
en-wikipedia-org-4107	318	5	to	to	IN
en-wikipedia-org-4107	318	6	confusion	confusion	NN
en-wikipedia-org-4107	318	7	that	that	WDT
en-wikipedia-org-4107	318	8	may	may	MD
en-wikipedia-org-4107	318	9	arise	arise	VB
en-wikipedia-org-4107	318	10	from	from	IN
en-wikipedia-org-4107	318	11	use	use	NN
en-wikipedia-org-4107	318	12	of	of	IN
en-wikipedia-org-4107	318	13	the	the	DT
en-wikipedia-org-4107	318	14	plural	plural	JJ
en-wikipedia-org-4107	318	15	form	form	NN
en-wikipedia-org-4107	318	16	,	,	,
en-wikipedia-org-4107	318	17	this	this	DT
en-wikipedia-org-4107	318	18	article	article	NN
en-wikipedia-org-4107	318	19	will	will	MD
en-wikipedia-org-4107	318	20	only	only	RB
en-wikipedia-org-4107	318	21	use	use	VB
en-wikipedia-org-4107	318	22	the	the	DT
en-wikipedia-org-4107	318	23	terms	term	NNS
en-wikipedia-org-4107	318	24	"	"	``
en-wikipedia-org-4107	318	25	amphetamine	amphetamine	NN
en-wikipedia-org-4107	318	26	"	"	''
en-wikipedia-org-4107	318	27	and	and	CC
en-wikipedia-org-4107	318	28	"	"	``
en-wikipedia-org-4107	318	29	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	318	30	"	"	''
en-wikipedia-org-4107	318	31	to	to	TO
en-wikipedia-org-4107	318	32	refer	refer	VB
en-wikipedia-org-4107	318	33	to	to	IN
en-wikipedia-org-4107	318	34	racemic	racemic	NNP
en-wikipedia-org-4107	318	35	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	318	36	,	,	,
en-wikipedia-org-4107	318	37	levoamphetamine	levoamphetamine	NNP
en-wikipedia-org-4107	318	38	,	,	,
en-wikipedia-org-4107	318	39	and	and	CC
en-wikipedia-org-4107	318	40	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	318	41	and	and	CC
en-wikipedia-org-4107	318	42	reserve	reserve	VBP
en-wikipedia-org-4107	318	43	the	the	DT
en-wikipedia-org-4107	318	44	term	term	NN
en-wikipedia-org-4107	318	45	"	"	``
en-wikipedia-org-4107	318	46	substituted	substitute	VBN
en-wikipedia-org-4107	318	47	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	318	48	"	"	''
en-wikipedia-org-4107	318	49	for	for	IN
en-wikipedia-org-4107	318	50	its	-PRON-	PRP$
en-wikipedia-org-4107	318	51	structural	structural	JJ
en-wikipedia-org-4107	318	52	class	class	NN
en-wikipedia-org-4107	318	53	.	.	.
en-wikipedia-org-4107	319	1	^	^	NNP
en-wikipedia-org-4107	319	2	The	the	DT
en-wikipedia-org-4107	319	3	ADHD	ADHD	NNP
en-wikipedia-org-4107	319	4	-	-	HYPH
en-wikipedia-org-4107	319	5	related	relate	VBN
en-wikipedia-org-4107	319	6	outcome	outcome	NN
en-wikipedia-org-4107	319	7	domains	domain	NNS
en-wikipedia-org-4107	319	8	with	with	IN
en-wikipedia-org-4107	319	9	the	the	DT
en-wikipedia-org-4107	319	10	greatest	great	JJS
en-wikipedia-org-4107	319	11	proportion	proportion	NN
en-wikipedia-org-4107	319	12	of	of	IN
en-wikipedia-org-4107	319	13	significantly	significantly	RB
en-wikipedia-org-4107	319	14	improved	improve	VBN
en-wikipedia-org-4107	319	15	outcomes	outcome	NNS
en-wikipedia-org-4107	319	16	from	from	IN
en-wikipedia-org-4107	319	17	long	long	JJ
en-wikipedia-org-4107	319	18	-	-	HYPH
en-wikipedia-org-4107	319	19	term	term	NN
en-wikipedia-org-4107	319	20	continuous	continuous	JJ
en-wikipedia-org-4107	319	21	stimulant	stimulant	NN
en-wikipedia-org-4107	319	22	therapy	therapy	NN
en-wikipedia-org-4107	319	23	include	include	VBP
en-wikipedia-org-4107	319	24	academics	academic	NNS
en-wikipedia-org-4107	319	25	(	(	-LRB-
en-wikipedia-org-4107	319	26	≈55	≈55	NNP
en-wikipedia-org-4107	319	27	%	%	NN
en-wikipedia-org-4107	319	28	of	of	IN
en-wikipedia-org-4107	319	29	academic	academic	JJ
en-wikipedia-org-4107	319	30	outcomes	outcome	NNS
en-wikipedia-org-4107	319	31	improved	improve	VBD
en-wikipedia-org-4107	319	32	)	)	-RRB-
en-wikipedia-org-4107	319	33	,	,	,
en-wikipedia-org-4107	319	34	driving	drive	VBG
en-wikipedia-org-4107	319	35	(	(	-LRB-
en-wikipedia-org-4107	319	36	100	100	CD
en-wikipedia-org-4107	319	37	%	%	NN
en-wikipedia-org-4107	319	38	of	of	IN
en-wikipedia-org-4107	319	39	driving	drive	VBG
en-wikipedia-org-4107	319	40	outcomes	outcome	NNS
en-wikipedia-org-4107	319	41	improved	improve	VBD
en-wikipedia-org-4107	319	42	)	)	-RRB-
en-wikipedia-org-4107	319	43	,	,	,
en-wikipedia-org-4107	319	44	non	non	JJ
en-wikipedia-org-4107	319	45	-	-	JJ
en-wikipedia-org-4107	319	46	medical	medical	JJ
en-wikipedia-org-4107	319	47	drug	drug	NN
en-wikipedia-org-4107	319	48	use	use	NN
en-wikipedia-org-4107	319	49	(	(	-LRB-
en-wikipedia-org-4107	319	50	47	47	CD
en-wikipedia-org-4107	319	51	%	%	NN
en-wikipedia-org-4107	319	52	of	of	IN
en-wikipedia-org-4107	319	53	addiction	addiction	NN
en-wikipedia-org-4107	319	54	-	-	HYPH
en-wikipedia-org-4107	319	55	related	relate	VBN
en-wikipedia-org-4107	319	56	outcomes	outcome	NNS
en-wikipedia-org-4107	319	57	improved	improve	VBD
en-wikipedia-org-4107	319	58	)	)	-RRB-
en-wikipedia-org-4107	319	59	,	,	,
en-wikipedia-org-4107	319	60	obesity	obesity	NN
en-wikipedia-org-4107	319	61	(	(	-LRB-
en-wikipedia-org-4107	319	62	≈65	≈65	CD
en-wikipedia-org-4107	319	63	%	%	NN
en-wikipedia-org-4107	319	64	of	of	IN
en-wikipedia-org-4107	319	65	obesity	obesity	NN
en-wikipedia-org-4107	319	66	-	-	HYPH
en-wikipedia-org-4107	319	67	related	relate	VBN
en-wikipedia-org-4107	319	68	outcomes	outcome	NNS
en-wikipedia-org-4107	319	69	improved	improve	VBD
en-wikipedia-org-4107	319	70	)	)	-RRB-
en-wikipedia-org-4107	319	71	,	,	,
en-wikipedia-org-4107	319	72	self	self	NN
en-wikipedia-org-4107	319	73	-	-	HYPH
en-wikipedia-org-4107	319	74	esteem	esteem	NN
en-wikipedia-org-4107	319	75	(	(	-LRB-
en-wikipedia-org-4107	319	76	50	50	CD
en-wikipedia-org-4107	319	77	%	%	NN
en-wikipedia-org-4107	319	78	of	of	IN
en-wikipedia-org-4107	319	79	self	self	NN
en-wikipedia-org-4107	319	80	-	-	HYPH
en-wikipedia-org-4107	319	81	esteem	esteem	NN
en-wikipedia-org-4107	319	82	outcomes	outcome	NNS
en-wikipedia-org-4107	319	83	improved	improve	VBD
en-wikipedia-org-4107	319	84	)	)	-RRB-
en-wikipedia-org-4107	319	85	,	,	,
en-wikipedia-org-4107	319	86	and	and	CC
en-wikipedia-org-4107	319	87	social	social	JJ
en-wikipedia-org-4107	319	88	function	function	NN
en-wikipedia-org-4107	319	89	(	(	-LRB-
en-wikipedia-org-4107	319	90	67	67	CD
en-wikipedia-org-4107	319	91	%	%	NN
en-wikipedia-org-4107	319	92	of	of	IN
en-wikipedia-org-4107	319	93	social	social	JJ
en-wikipedia-org-4107	319	94	function	function	NN
en-wikipedia-org-4107	319	95	outcomes	outcome	NNS
en-wikipedia-org-4107	319	96	improved	improve	VBD
en-wikipedia-org-4107	319	97	)	)	-RRB-
en-wikipedia-org-4107	319	98	.	.	.
en-wikipedia-org-4107	320	1	[	[	-LRB-
en-wikipedia-org-4107	320	2	56	56	CD
en-wikipedia-org-4107	320	3	]	]	-RRB-
en-wikipedia-org-4107	320	4	The	the	DT
en-wikipedia-org-4107	320	5	largest	large	JJS
en-wikipedia-org-4107	320	6	effect	effect	NN
en-wikipedia-org-4107	320	7	sizes	size	VBZ
en-wikipedia-org-4107	320	8	for	for	IN
en-wikipedia-org-4107	320	9	outcome	outcome	NN
en-wikipedia-org-4107	320	10	improvements	improvement	NNS
en-wikipedia-org-4107	320	11	from	from	IN
en-wikipedia-org-4107	320	12	long	long	JJ
en-wikipedia-org-4107	320	13	-	-	HYPH
en-wikipedia-org-4107	320	14	term	term	NN
en-wikipedia-org-4107	320	15	stimulant	stimulant	NN
en-wikipedia-org-4107	320	16	therapy	therapy	NN
en-wikipedia-org-4107	320	17	occur	occur	VBP
en-wikipedia-org-4107	320	18	in	in	IN
en-wikipedia-org-4107	320	19	the	the	DT
en-wikipedia-org-4107	320	20	domains	domain	NNS
en-wikipedia-org-4107	320	21	involving	involve	VBG
en-wikipedia-org-4107	320	22	academics	academic	NNS
en-wikipedia-org-4107	320	23	(	(	-LRB-
en-wikipedia-org-4107	320	24	e.g.	e.g.	RB
en-wikipedia-org-4107	320	25	,	,	,
en-wikipedia-org-4107	320	26	grade	grade	NN
en-wikipedia-org-4107	320	27	point	point	NN
en-wikipedia-org-4107	320	28	average	average	JJ
en-wikipedia-org-4107	320	29	,	,	,
en-wikipedia-org-4107	320	30	achievement	achievement	NN
en-wikipedia-org-4107	320	31	test	test	NN
en-wikipedia-org-4107	320	32	scores	score	NNS
en-wikipedia-org-4107	320	33	,	,	,
en-wikipedia-org-4107	320	34	length	length	NN
en-wikipedia-org-4107	320	35	of	of	IN
en-wikipedia-org-4107	320	36	education	education	NN
en-wikipedia-org-4107	320	37	,	,	,
en-wikipedia-org-4107	320	38	and	and	CC
en-wikipedia-org-4107	320	39	education	education	NN
en-wikipedia-org-4107	320	40	level	level	NN
en-wikipedia-org-4107	320	41	)	)	-RRB-
en-wikipedia-org-4107	320	42	,	,	,
en-wikipedia-org-4107	320	43	self	self	NN
en-wikipedia-org-4107	320	44	-	-	HYPH
en-wikipedia-org-4107	320	45	esteem	esteem	NN
en-wikipedia-org-4107	320	46	(	(	-LRB-
en-wikipedia-org-4107	320	47	e.g.	e.g.	RB
en-wikipedia-org-4107	320	48	,	,	,
en-wikipedia-org-4107	320	49	self	self	NN
en-wikipedia-org-4107	320	50	-	-	HYPH
en-wikipedia-org-4107	320	51	esteem	esteem	NN
en-wikipedia-org-4107	320	52	questionnaire	questionnaire	NN
en-wikipedia-org-4107	320	53	assessments	assessment	NNS
en-wikipedia-org-4107	320	54	,	,	,
en-wikipedia-org-4107	320	55	number	number	NN
en-wikipedia-org-4107	320	56	of	of	IN
en-wikipedia-org-4107	320	57	suicide	suicide	NN
en-wikipedia-org-4107	320	58	attempts	attempt	NNS
en-wikipedia-org-4107	320	59	,	,	,
en-wikipedia-org-4107	320	60	and	and	CC
en-wikipedia-org-4107	320	61	suicide	suicide	NN
en-wikipedia-org-4107	320	62	rates	rate	NNS
en-wikipedia-org-4107	320	63	)	)	-RRB-
en-wikipedia-org-4107	320	64	,	,	,
en-wikipedia-org-4107	320	65	and	and	CC
en-wikipedia-org-4107	320	66	social	social	JJ
en-wikipedia-org-4107	320	67	function	function	NN
en-wikipedia-org-4107	320	68	(	(	-LRB-
en-wikipedia-org-4107	320	69	e.g.	e.g.	RB
en-wikipedia-org-4107	320	70	,	,	,
en-wikipedia-org-4107	320	71	peer	peer	NN
en-wikipedia-org-4107	320	72	nomination	nomination	NN
en-wikipedia-org-4107	320	73	scores	score	NNS
en-wikipedia-org-4107	320	74	,	,	,
en-wikipedia-org-4107	320	75	social	social	JJ
en-wikipedia-org-4107	320	76	skills	skill	NNS
en-wikipedia-org-4107	320	77	,	,	,
en-wikipedia-org-4107	320	78	and	and	CC
en-wikipedia-org-4107	320	79	quality	quality	NN
en-wikipedia-org-4107	320	80	of	of	IN
en-wikipedia-org-4107	320	81	peer	peer	NN
en-wikipedia-org-4107	320	82	,	,	,
en-wikipedia-org-4107	320	83	family	family	NN
en-wikipedia-org-4107	320	84	,	,	,
en-wikipedia-org-4107	320	85	and	and	CC
en-wikipedia-org-4107	320	86	romantic	romantic	JJ
en-wikipedia-org-4107	320	87	relationships	relationship	NNS
en-wikipedia-org-4107	320	88	)	)	-RRB-
en-wikipedia-org-4107	320	89	.	.	.
en-wikipedia-org-4107	321	1	[	[	-LRB-
en-wikipedia-org-4107	321	2	56	56	CD
en-wikipedia-org-4107	321	3	]	]	-RRB-
en-wikipedia-org-4107	321	4	Long	long	JJ
en-wikipedia-org-4107	321	5	-	-	HYPH
en-wikipedia-org-4107	321	6	term	term	NN
en-wikipedia-org-4107	321	7	combination	combination	NN
en-wikipedia-org-4107	321	8	therapy	therapy	NN
en-wikipedia-org-4107	321	9	for	for	IN
en-wikipedia-org-4107	321	10	ADHD	ADHD	NNP
en-wikipedia-org-4107	321	11	(	(	-LRB-
en-wikipedia-org-4107	321	12	i.e.	i.e.	FW
en-wikipedia-org-4107	321	13	,	,	,
en-wikipedia-org-4107	321	14	treatment	treatment	NN
en-wikipedia-org-4107	321	15	with	with	IN
en-wikipedia-org-4107	321	16	both	both	CC
en-wikipedia-org-4107	321	17	a	a	DT
en-wikipedia-org-4107	321	18	stimulant	stimulant	NN
en-wikipedia-org-4107	321	19	and	and	CC
en-wikipedia-org-4107	321	20	behavioral	behavioral	JJ
en-wikipedia-org-4107	321	21	therapy	therapy	NN
en-wikipedia-org-4107	321	22	)	)	-RRB-
en-wikipedia-org-4107	321	23	produces	produce	VBZ
en-wikipedia-org-4107	321	24	even	even	RB
en-wikipedia-org-4107	321	25	larger	large	JJR
en-wikipedia-org-4107	321	26	effect	effect	NN
en-wikipedia-org-4107	321	27	sizes	size	NNS
en-wikipedia-org-4107	321	28	for	for	IN
en-wikipedia-org-4107	321	29	outcome	outcome	NN
en-wikipedia-org-4107	321	30	improvements	improvement	NNS
en-wikipedia-org-4107	321	31	and	and	CC
en-wikipedia-org-4107	321	32	improves	improve	VBZ
en-wikipedia-org-4107	321	33	a	a	DT
en-wikipedia-org-4107	321	34	larger	large	JJR
en-wikipedia-org-4107	321	35	proportion	proportion	NN
en-wikipedia-org-4107	321	36	of	of	IN
en-wikipedia-org-4107	321	37	outcomes	outcome	NNS
en-wikipedia-org-4107	321	38	across	across	IN
en-wikipedia-org-4107	321	39	each	each	DT
en-wikipedia-org-4107	321	40	domain	domain	NN
en-wikipedia-org-4107	321	41	compared	compare	VBN
en-wikipedia-org-4107	321	42	to	to	IN
en-wikipedia-org-4107	321	43	long	long	JJ
en-wikipedia-org-4107	321	44	-	-	HYPH
en-wikipedia-org-4107	321	45	term	term	NN
en-wikipedia-org-4107	321	46	stimulant	stimulant	NN
en-wikipedia-org-4107	321	47	therapy	therapy	NN
en-wikipedia-org-4107	321	48	alone	alone	RB
en-wikipedia-org-4107	321	49	.	.	.
en-wikipedia-org-4107	322	1	[	[	-LRB-
en-wikipedia-org-4107	322	2	56	56	CD
en-wikipedia-org-4107	322	3	]	]	-RRB-
en-wikipedia-org-4107	322	4	^	^	.
en-wikipedia-org-4107	322	5	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	322	6	reviews	review	NNS
en-wikipedia-org-4107	322	7	are	be	VBP
en-wikipedia-org-4107	322	8	high	high	JJ
en-wikipedia-org-4107	322	9	quality	quality	NN
en-wikipedia-org-4107	322	10	meta	meta	JJ
en-wikipedia-org-4107	322	11	-	-	HYPH
en-wikipedia-org-4107	322	12	analytic	analytic	JJ
en-wikipedia-org-4107	322	13	systematic	systematic	JJ
en-wikipedia-org-4107	322	14	reviews	review	NNS
en-wikipedia-org-4107	322	15	of	of	IN
en-wikipedia-org-4107	322	16	randomized	randomized	JJ
en-wikipedia-org-4107	322	17	controlled	controlled	JJ
en-wikipedia-org-4107	322	18	trials	trial	NNS
en-wikipedia-org-4107	322	19	.	.	.
en-wikipedia-org-4107	323	1	[	[	-LRB-
en-wikipedia-org-4107	323	2	62	62	CD
en-wikipedia-org-4107	323	3	]	]	-RRB-
en-wikipedia-org-4107	323	4	^	^	.
en-wikipedia-org-4107	323	5	The	the	DT
en-wikipedia-org-4107	323	6	statements	statement	NNS
en-wikipedia-org-4107	323	7	supported	support	VBN
en-wikipedia-org-4107	323	8	by	by	IN
en-wikipedia-org-4107	323	9	the	the	DT
en-wikipedia-org-4107	323	10	USFDA	USFDA	NNP
en-wikipedia-org-4107	323	11	come	come	VBP
en-wikipedia-org-4107	323	12	from	from	IN
en-wikipedia-org-4107	323	13	prescribing	prescribe	VBG
en-wikipedia-org-4107	323	14	information	information	NN
en-wikipedia-org-4107	323	15	,	,	,
en-wikipedia-org-4107	323	16	which	which	WDT
en-wikipedia-org-4107	323	17	is	be	VBZ
en-wikipedia-org-4107	323	18	the	the	DT
en-wikipedia-org-4107	323	19	copyrighted	copyright	VBN
en-wikipedia-org-4107	323	20	intellectual	intellectual	JJ
en-wikipedia-org-4107	323	21	property	property	NN
en-wikipedia-org-4107	323	22	of	of	IN
en-wikipedia-org-4107	323	23	the	the	DT
en-wikipedia-org-4107	323	24	manufacturer	manufacturer	NN
en-wikipedia-org-4107	323	25	and	and	CC
en-wikipedia-org-4107	323	26	approved	approve	VBN
en-wikipedia-org-4107	323	27	by	by	IN
en-wikipedia-org-4107	323	28	the	the	DT
en-wikipedia-org-4107	323	29	USFDA	USFDA	NNP
en-wikipedia-org-4107	323	30	.	.	.
en-wikipedia-org-4107	324	1	USFDA	usfda	NN
en-wikipedia-org-4107	324	2	contraindications	contraindication	NNS
en-wikipedia-org-4107	324	3	are	be	VBP
en-wikipedia-org-4107	324	4	not	not	RB
en-wikipedia-org-4107	324	5	necessarily	necessarily	RB
en-wikipedia-org-4107	324	6	intended	intend	VBN
en-wikipedia-org-4107	324	7	to	to	TO
en-wikipedia-org-4107	324	8	limit	limit	VB
en-wikipedia-org-4107	324	9	medical	medical	JJ
en-wikipedia-org-4107	324	10	practice	practice	NN
en-wikipedia-org-4107	324	11	but	but	CC
en-wikipedia-org-4107	324	12	limit	limit	NN
en-wikipedia-org-4107	324	13	claims	claim	NNS
en-wikipedia-org-4107	324	14	by	by	IN
en-wikipedia-org-4107	324	15	pharmaceutical	pharmaceutical	NN
en-wikipedia-org-4107	324	16	companies	company	NNS
en-wikipedia-org-4107	324	17	.	.	.
en-wikipedia-org-4107	325	1	[	[	-LRB-
en-wikipedia-org-4107	325	2	83	83	CD
en-wikipedia-org-4107	325	3	]	]	-RRB-
en-wikipedia-org-4107	325	4	^	^	.
en-wikipedia-org-4107	325	5	According	accord	VBG
en-wikipedia-org-4107	325	6	to	to	IN
en-wikipedia-org-4107	325	7	one	one	CD
en-wikipedia-org-4107	325	8	review	review	NN
en-wikipedia-org-4107	325	9	,	,	,
en-wikipedia-org-4107	325	10	amphetamine	amphetamine	NN
en-wikipedia-org-4107	325	11	can	can	MD
en-wikipedia-org-4107	325	12	be	be	VB
en-wikipedia-org-4107	325	13	prescribed	prescribe	VBN
en-wikipedia-org-4107	325	14	to	to	IN
en-wikipedia-org-4107	325	15	individuals	individual	NNS
en-wikipedia-org-4107	325	16	with	with	IN
en-wikipedia-org-4107	325	17	a	a	DT
en-wikipedia-org-4107	325	18	history	history	NN
en-wikipedia-org-4107	325	19	of	of	IN
en-wikipedia-org-4107	325	20	abuse	abuse	NN
en-wikipedia-org-4107	325	21	provided	provide	VBD
en-wikipedia-org-4107	325	22	that	that	IN
en-wikipedia-org-4107	325	23	appropriate	appropriate	JJ
en-wikipedia-org-4107	325	24	medication	medication	NN
en-wikipedia-org-4107	325	25	controls	control	NNS
en-wikipedia-org-4107	325	26	are	be	VBP
en-wikipedia-org-4107	325	27	employed	employ	VBN
en-wikipedia-org-4107	325	28	,	,	,
en-wikipedia-org-4107	325	29	such	such	JJ
en-wikipedia-org-4107	325	30	as	as	IN
en-wikipedia-org-4107	325	31	requiring	require	VBG
en-wikipedia-org-4107	325	32	daily	daily	JJ
en-wikipedia-org-4107	325	33	pick	pick	NN
en-wikipedia-org-4107	325	34	-	-	HYPH
en-wikipedia-org-4107	325	35	ups	up	NNS
en-wikipedia-org-4107	325	36	of	of	IN
en-wikipedia-org-4107	325	37	the	the	DT
en-wikipedia-org-4107	325	38	medication	medication	NN
en-wikipedia-org-4107	325	39	from	from	IN
en-wikipedia-org-4107	325	40	the	the	DT
en-wikipedia-org-4107	325	41	prescribing	prescribing	NN
en-wikipedia-org-4107	325	42	physician	physician	NN
en-wikipedia-org-4107	325	43	.	.	.
en-wikipedia-org-4107	326	1	[	[	-LRB-
en-wikipedia-org-4107	326	2	3	3	CD
en-wikipedia-org-4107	326	3	]	]	-RRB-
en-wikipedia-org-4107	326	4	^	^	NN
en-wikipedia-org-4107	326	5	In	in	IN
en-wikipedia-org-4107	326	6	individuals	individual	NNS
en-wikipedia-org-4107	326	7	who	who	WP
en-wikipedia-org-4107	326	8	experience	experience	VBP
en-wikipedia-org-4107	326	9	sub	sub	JJ
en-wikipedia-org-4107	326	10	-	-	JJ
en-wikipedia-org-4107	326	11	normal	normal	JJ
en-wikipedia-org-4107	326	12	height	height	NN
en-wikipedia-org-4107	326	13	and	and	CC
en-wikipedia-org-4107	326	14	weight	weight	NN
en-wikipedia-org-4107	326	15	gains	gain	NNS
en-wikipedia-org-4107	326	16	,	,	,
en-wikipedia-org-4107	326	17	a	a	DT
en-wikipedia-org-4107	326	18	rebound	rebound	NN
en-wikipedia-org-4107	326	19	to	to	IN
en-wikipedia-org-4107	326	20	normal	normal	JJ
en-wikipedia-org-4107	326	21	levels	level	NNS
en-wikipedia-org-4107	326	22	is	be	VBZ
en-wikipedia-org-4107	326	23	expected	expect	VBN
en-wikipedia-org-4107	326	24	to	to	TO
en-wikipedia-org-4107	326	25	occur	occur	VB
en-wikipedia-org-4107	326	26	if	if	IN
en-wikipedia-org-4107	326	27	stimulant	stimulant	NN
en-wikipedia-org-4107	326	28	therapy	therapy	NN
en-wikipedia-org-4107	326	29	is	be	VBZ
en-wikipedia-org-4107	326	30	briefly	briefly	RB
en-wikipedia-org-4107	326	31	interrupted	interrupt	VBN
en-wikipedia-org-4107	326	32	.	.	.
en-wikipedia-org-4107	327	1	[	[	-LRB-
en-wikipedia-org-4107	327	2	43][55][87	43][55][87	CD
en-wikipedia-org-4107	327	3	]	]	-RRB-
en-wikipedia-org-4107	327	4	The	the	DT
en-wikipedia-org-4107	327	5	average	average	JJ
en-wikipedia-org-4107	327	6	reduction	reduction	NN
en-wikipedia-org-4107	327	7	in	in	IN
en-wikipedia-org-4107	327	8	final	final	JJ
en-wikipedia-org-4107	327	9	adult	adult	NN
en-wikipedia-org-4107	327	10	height	height	NN
en-wikipedia-org-4107	327	11	from	from	IN
en-wikipedia-org-4107	327	12	3	3	CD
en-wikipedia-org-4107	327	13	 	  	_SP
en-wikipedia-org-4107	327	14	years	year	NNS
en-wikipedia-org-4107	327	15	of	of	IN
en-wikipedia-org-4107	327	16	continuous	continuous	JJ
en-wikipedia-org-4107	327	17	stimulant	stimulant	NN
en-wikipedia-org-4107	327	18	therapy	therapy	NN
en-wikipedia-org-4107	327	19	is	be	VBZ
en-wikipedia-org-4107	327	20	2	2	CD
en-wikipedia-org-4107	327	21	 	  	_SP
en-wikipedia-org-4107	327	22	cm	cm	NNP
en-wikipedia-org-4107	327	23	.	.	.
en-wikipedia-org-4107	328	1	[	[	-LRB-
en-wikipedia-org-4107	328	2	87	87	CD
en-wikipedia-org-4107	328	3	]	]	-RRB-
en-wikipedia-org-4107	328	4	^	^	NN
en-wikipedia-org-4107	328	5	Transcription	transcription	NN
en-wikipedia-org-4107	328	6	factors	factor	NNS
en-wikipedia-org-4107	328	7	are	be	VBP
en-wikipedia-org-4107	328	8	proteins	protein	NNS
en-wikipedia-org-4107	328	9	that	that	WDT
en-wikipedia-org-4107	328	10	increase	increase	VBP
en-wikipedia-org-4107	328	11	or	or	CC
en-wikipedia-org-4107	328	12	decrease	decrease	VB
en-wikipedia-org-4107	328	13	the	the	DT
en-wikipedia-org-4107	328	14	expression	expression	NN
en-wikipedia-org-4107	328	15	of	of	IN
en-wikipedia-org-4107	328	16	specific	specific	JJ
en-wikipedia-org-4107	328	17	genes	gene	NNS
en-wikipedia-org-4107	328	18	.	.	.
en-wikipedia-org-4107	329	1	[	[	-LRB-
en-wikipedia-org-4107	329	2	116	116	CD
en-wikipedia-org-4107	329	3	]	]	-RRB-
en-wikipedia-org-4107	329	4	^	^	.
en-wikipedia-org-4107	329	5	In	in	IN
en-wikipedia-org-4107	329	6	simpler	simple	JJR
en-wikipedia-org-4107	329	7	terms	term	NNS
en-wikipedia-org-4107	329	8	,	,	,
en-wikipedia-org-4107	329	9	this	this	DT
en-wikipedia-org-4107	329	10	necessary	necessary	JJ
en-wikipedia-org-4107	329	11	and	and	CC
en-wikipedia-org-4107	329	12	sufficient	sufficient	JJ
en-wikipedia-org-4107	329	13	relationship	relationship	NN
en-wikipedia-org-4107	329	14	means	mean	VBZ
en-wikipedia-org-4107	329	15	that	that	IN
en-wikipedia-org-4107	329	16	ΔFosB	ΔFosB	VBZ
en-wikipedia-org-4107	329	17	overexpression	overexpression	NN
en-wikipedia-org-4107	329	18	in	in	IN
en-wikipedia-org-4107	329	19	the	the	DT
en-wikipedia-org-4107	329	20	nucleus	nucleus	NN
en-wikipedia-org-4107	329	21	accumbens	accumben	NNS
en-wikipedia-org-4107	329	22	and	and	CC
en-wikipedia-org-4107	329	23	addiction	addiction	NN
en-wikipedia-org-4107	329	24	-	-	HYPH
en-wikipedia-org-4107	329	25	related	relate	VBN
en-wikipedia-org-4107	329	26	behavioral	behavioral	JJ
en-wikipedia-org-4107	329	27	and	and	CC
en-wikipedia-org-4107	329	28	neural	neural	JJ
en-wikipedia-org-4107	329	29	adaptations	adaptation	NNS
en-wikipedia-org-4107	329	30	always	always	RB
en-wikipedia-org-4107	329	31	occur	occur	VBP
en-wikipedia-org-4107	329	32	together	together	RB
en-wikipedia-org-4107	329	33	and	and	CC
en-wikipedia-org-4107	329	34	never	never	RB
en-wikipedia-org-4107	329	35	occur	occur	VB
en-wikipedia-org-4107	329	36	alone	alone	JJ
en-wikipedia-org-4107	329	37	.	.	.
en-wikipedia-org-4107	330	1	^	^	NFP
en-wikipedia-org-4107	330	2	NMDA	NMDA	NNP
en-wikipedia-org-4107	330	3	receptors	receptor	NNS
en-wikipedia-org-4107	330	4	are	be	VBP
en-wikipedia-org-4107	330	5	voltage	voltage	NN
en-wikipedia-org-4107	330	6	-	-	HYPH
en-wikipedia-org-4107	330	7	dependent	dependent	JJ
en-wikipedia-org-4107	330	8	ligand	ligand	NN
en-wikipedia-org-4107	330	9	-	-	HYPH
en-wikipedia-org-4107	330	10	gated	gate	VBN
en-wikipedia-org-4107	330	11	ion	ion	NN
en-wikipedia-org-4107	330	12	channels	channel	NNS
en-wikipedia-org-4107	330	13	that	that	WDT
en-wikipedia-org-4107	330	14	requires	require	VBZ
en-wikipedia-org-4107	330	15	simultaneous	simultaneous	JJ
en-wikipedia-org-4107	330	16	binding	binding	NN
en-wikipedia-org-4107	330	17	of	of	IN
en-wikipedia-org-4107	330	18	glutamate	glutamate	NN
en-wikipedia-org-4107	330	19	and	and	CC
en-wikipedia-org-4107	330	20	a	a	DT
en-wikipedia-org-4107	330	21	co	co	NN
en-wikipedia-org-4107	330	22	-	-	NN
en-wikipedia-org-4107	330	23	agonist	agonist	JJ
en-wikipedia-org-4107	330	24	(	(	-LRB-
en-wikipedia-org-4107	330	25	D	d	JJ
en-wikipedia-org-4107	330	26	-	-	HYPH
en-wikipedia-org-4107	330	27	serine	serine	NN
en-wikipedia-org-4107	330	28	or	or	CC
en-wikipedia-org-4107	330	29	glycine	glycine	NN
en-wikipedia-org-4107	330	30	)	)	-RRB-
en-wikipedia-org-4107	330	31	to	to	TO
en-wikipedia-org-4107	330	32	open	open	VB
en-wikipedia-org-4107	330	33	the	the	DT
en-wikipedia-org-4107	330	34	ion	ion	NN
en-wikipedia-org-4107	330	35	channel	channel	NN
en-wikipedia-org-4107	330	36	.	.	.
en-wikipedia-org-4107	331	1	[	[	-LRB-
en-wikipedia-org-4107	331	2	130	130	CD
en-wikipedia-org-4107	331	3	]	]	-RRB-
en-wikipedia-org-4107	331	4	^	^	FW
en-wikipedia-org-4107	331	5	The	the	DT
en-wikipedia-org-4107	331	6	review	review	NN
en-wikipedia-org-4107	331	7	indicated	indicate	VBD
en-wikipedia-org-4107	331	8	that	that	IN
en-wikipedia-org-4107	331	9	magnesium	magnesium	NN
en-wikipedia-org-4107	331	10	L	l	NN
en-wikipedia-org-4107	331	11	-	-	HYPH
en-wikipedia-org-4107	331	12	aspartate	aspartate	NN
en-wikipedia-org-4107	331	13	and	and	CC
en-wikipedia-org-4107	331	14	magnesium	magnesium	NN
en-wikipedia-org-4107	331	15	chloride	chloride	NN
en-wikipedia-org-4107	331	16	produce	produce	VBP
en-wikipedia-org-4107	331	17	significant	significant	JJ
en-wikipedia-org-4107	331	18	changes	change	NNS
en-wikipedia-org-4107	331	19	in	in	IN
en-wikipedia-org-4107	331	20	addictive	addictive	JJ
en-wikipedia-org-4107	331	21	behavior;[107	behavior;[107	NNP
en-wikipedia-org-4107	331	22	]	]	-RRB-
en-wikipedia-org-4107	331	23	other	other	JJ
en-wikipedia-org-4107	331	24	forms	form	NNS
en-wikipedia-org-4107	331	25	of	of	IN
en-wikipedia-org-4107	331	26	magnesium	magnesium	NN
en-wikipedia-org-4107	331	27	were	be	VBD
en-wikipedia-org-4107	331	28	not	not	RB
en-wikipedia-org-4107	331	29	mentioned	mention	VBN
en-wikipedia-org-4107	331	30	.	.	.
en-wikipedia-org-4107	332	1	^	^	NFP
en-wikipedia-org-4107	332	2	The	the	DT
en-wikipedia-org-4107	332	3	95	95	CD
en-wikipedia-org-4107	332	4	%	%	NN
en-wikipedia-org-4107	332	5	 	  	_SP
en-wikipedia-org-4107	332	6	confidence	confidence	NN
en-wikipedia-org-4107	332	7	interval	interval	NN
en-wikipedia-org-4107	332	8	indicates	indicate	VBZ
en-wikipedia-org-4107	332	9	that	that	IN
en-wikipedia-org-4107	332	10	there	there	EX
en-wikipedia-org-4107	332	11	is	be	VBZ
en-wikipedia-org-4107	332	12	a	a	DT
en-wikipedia-org-4107	332	13	95	95	CD
en-wikipedia-org-4107	332	14	%	%	NN
en-wikipedia-org-4107	332	15	 	  	_SP
en-wikipedia-org-4107	332	16	probability	probability	NN
en-wikipedia-org-4107	332	17	that	that	IN
en-wikipedia-org-4107	332	18	the	the	DT
en-wikipedia-org-4107	332	19	true	true	JJ
en-wikipedia-org-4107	332	20	number	number	NN
en-wikipedia-org-4107	332	21	of	of	IN
en-wikipedia-org-4107	332	22	deaths	death	NNS
en-wikipedia-org-4107	332	23	lies	lie	VBZ
en-wikipedia-org-4107	332	24	between	between	IN
en-wikipedia-org-4107	332	25	3,425	3,425	CD
en-wikipedia-org-4107	332	26	and	and	CC
en-wikipedia-org-4107	332	27	4,145	4,145	CD
en-wikipedia-org-4107	332	28	.	.	.
en-wikipedia-org-4107	333	1	^	^	NNP
en-wikipedia-org-4107	333	2	a	a	DT
en-wikipedia-org-4107	333	3	b	b	NN
en-wikipedia-org-4107	333	4	The	the	DT
en-wikipedia-org-4107	333	5	human	human	JJ
en-wikipedia-org-4107	333	6	dopamine	dopamine	NN
en-wikipedia-org-4107	333	7	transporter	transporter	NN
en-wikipedia-org-4107	333	8	(	(	-LRB-
en-wikipedia-org-4107	333	9	hDAT	hDAT	NNP
en-wikipedia-org-4107	333	10	)	)	-RRB-
en-wikipedia-org-4107	333	11	contains	contain	VBZ
en-wikipedia-org-4107	333	12	a	a	DT
en-wikipedia-org-4107	333	13	high	high	JJ
en-wikipedia-org-4107	333	14	-	-	HYPH
en-wikipedia-org-4107	333	15	affinity	affinity	NN
en-wikipedia-org-4107	333	16	,	,	,
en-wikipedia-org-4107	333	17	extracellular	extracellular	NNP
en-wikipedia-org-4107	333	18	,	,	,
en-wikipedia-org-4107	333	19	and	and	CC
en-wikipedia-org-4107	333	20	allosteric	allosteric	JJ
en-wikipedia-org-4107	333	21	Zn2	Zn2	NNP
en-wikipedia-org-4107	333	22	+	+	NFP
en-wikipedia-org-4107	333	23	(	(	-LRB-
en-wikipedia-org-4107	333	24	zinc	zinc	NN
en-wikipedia-org-4107	333	25	ion	ion	NN
en-wikipedia-org-4107	333	26	)	)	-RRB-
en-wikipedia-org-4107	333	27	binding	bind	VBG
en-wikipedia-org-4107	333	28	site	site	NN
en-wikipedia-org-4107	333	29	which	which	WDT
en-wikipedia-org-4107	333	30	,	,	,
en-wikipedia-org-4107	333	31	upon	upon	IN
en-wikipedia-org-4107	333	32	zinc	zinc	NN
en-wikipedia-org-4107	333	33	binding	binding	NN
en-wikipedia-org-4107	333	34	,	,	,
en-wikipedia-org-4107	333	35	inhibits	inhibit	VBZ
en-wikipedia-org-4107	333	36	dopamine	dopamine	NNP
en-wikipedia-org-4107	333	37	reuptake	reuptake	NN
en-wikipedia-org-4107	333	38	,	,	,
en-wikipedia-org-4107	333	39	inhibits	inhibit	VBZ
en-wikipedia-org-4107	333	40	amphetamine	amphetamine	NN
en-wikipedia-org-4107	333	41	-	-	HYPH
en-wikipedia-org-4107	333	42	induced	induce	VBN
en-wikipedia-org-4107	333	43	hDAT	hdat	NN
en-wikipedia-org-4107	333	44	internalization	internalization	NN
en-wikipedia-org-4107	333	45	,	,	,
en-wikipedia-org-4107	333	46	and	and	CC
en-wikipedia-org-4107	333	47	amplifies	amplifie	NNS
en-wikipedia-org-4107	333	48	amphetamine	amphetamine	VBP
en-wikipedia-org-4107	333	49	-	-	HYPH
en-wikipedia-org-4107	333	50	induced	induce	VBN
en-wikipedia-org-4107	333	51	dopamine	dopamine	NN
en-wikipedia-org-4107	333	52	efflux	efflux	NN
en-wikipedia-org-4107	333	53	.	.	.
en-wikipedia-org-4107	334	1	[	[	-LRB-
en-wikipedia-org-4107	334	2	146][147][148][149	146][147][148][149	LS
en-wikipedia-org-4107	334	3	]	]	-RRB-
en-wikipedia-org-4107	334	4	The	the	DT
en-wikipedia-org-4107	334	5	human	human	JJ
en-wikipedia-org-4107	334	6	serotonin	serotonin	JJ
en-wikipedia-org-4107	334	7	transporter	transporter	NN
en-wikipedia-org-4107	334	8	and	and	CC
en-wikipedia-org-4107	334	9	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	334	10	transporter	transporter	NN
en-wikipedia-org-4107	334	11	do	do	VBP
en-wikipedia-org-4107	334	12	not	not	RB
en-wikipedia-org-4107	334	13	contain	contain	VB
en-wikipedia-org-4107	334	14	zinc	zinc	NN
en-wikipedia-org-4107	334	15	binding	bind	VBG
en-wikipedia-org-4107	334	16	sites	site	NNS
en-wikipedia-org-4107	334	17	.	.	.
en-wikipedia-org-4107	335	1	[	[	-LRB-
en-wikipedia-org-4107	335	2	148	148	CD
en-wikipedia-org-4107	335	3	]	]	-RRB-
en-wikipedia-org-4107	335	4	^	^	NNP
en-wikipedia-org-4107	335	5	4-Hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	335	6	has	have	VBZ
en-wikipedia-org-4107	335	7	been	be	VBN
en-wikipedia-org-4107	335	8	shown	show	VBN
en-wikipedia-org-4107	335	9	to	to	TO
en-wikipedia-org-4107	335	10	be	be	VB
en-wikipedia-org-4107	335	11	metabolized	metabolize	VBN
en-wikipedia-org-4107	335	12	into	into	IN
en-wikipedia-org-4107	335	13	4-hydroxynorephedrine	4-hydroxynorephedrine	CD
en-wikipedia-org-4107	335	14	by	by	IN
en-wikipedia-org-4107	335	15	dopamine	dopamine	NN
en-wikipedia-org-4107	335	16	beta	beta	NN
en-wikipedia-org-4107	335	17	-	-	HYPH
en-wikipedia-org-4107	335	18	hydroxylase	hydroxylase	NN
en-wikipedia-org-4107	335	19	(	(	-LRB-
en-wikipedia-org-4107	335	20	DBH	DBH	NNP
en-wikipedia-org-4107	335	21	)	)	-RRB-
en-wikipedia-org-4107	335	22	in	in	IN
en-wikipedia-org-4107	335	23	vitro	vitro	FW
en-wikipedia-org-4107	335	24	and	and	CC
en-wikipedia-org-4107	335	25	it	-PRON-	PRP
en-wikipedia-org-4107	335	26	is	be	VBZ
en-wikipedia-org-4107	335	27	presumed	presume	VBN
en-wikipedia-org-4107	335	28	to	to	TO
en-wikipedia-org-4107	335	29	be	be	VB
en-wikipedia-org-4107	335	30	metabolized	metabolize	VBN
en-wikipedia-org-4107	335	31	similarly	similarly	RB
en-wikipedia-org-4107	335	32	in	in	IN
en-wikipedia-org-4107	335	33	vivo	vivo	NNP
en-wikipedia-org-4107	335	34	.	.	.
en-wikipedia-org-4107	336	1	[	[	-LRB-
en-wikipedia-org-4107	336	2	14][187	14][187	LS
en-wikipedia-org-4107	336	3	]	]	-RRB-
en-wikipedia-org-4107	336	4	Evidence	evidence	NN
en-wikipedia-org-4107	336	5	from	from	IN
en-wikipedia-org-4107	336	6	studies	study	NNS
en-wikipedia-org-4107	336	7	that	that	WDT
en-wikipedia-org-4107	336	8	measured	measure	VBD
en-wikipedia-org-4107	336	9	the	the	DT
en-wikipedia-org-4107	336	10	effect	effect	NN
en-wikipedia-org-4107	336	11	of	of	IN
en-wikipedia-org-4107	336	12	serum	serum	NN
en-wikipedia-org-4107	336	13	DBH	DBH	NNP
en-wikipedia-org-4107	336	14	concentrations	concentration	NNS
en-wikipedia-org-4107	336	15	on	on	IN
en-wikipedia-org-4107	336	16	4-hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	336	17	metabolism	metabolism	NN
en-wikipedia-org-4107	336	18	in	in	IN
en-wikipedia-org-4107	336	19	humans	human	NNS
en-wikipedia-org-4107	336	20	suggests	suggest	VBZ
en-wikipedia-org-4107	336	21	that	that	IN
en-wikipedia-org-4107	336	22	a	a	DT
en-wikipedia-org-4107	336	23	different	different	JJ
en-wikipedia-org-4107	336	24	enzyme	enzyme	NNS
en-wikipedia-org-4107	336	25	may	may	MD
en-wikipedia-org-4107	336	26	mediate	mediate	VB
en-wikipedia-org-4107	336	27	the	the	DT
en-wikipedia-org-4107	336	28	conversion	conversion	NN
en-wikipedia-org-4107	336	29	of	of	IN
en-wikipedia-org-4107	336	30	4-hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	336	31	to	to	IN
en-wikipedia-org-4107	336	32	4-hydroxynorephedrine;[187][189	4-hydroxynorephedrine;[187][189	CD
en-wikipedia-org-4107	336	33	]	]	-RRB-
en-wikipedia-org-4107	336	34	however	however	RB
en-wikipedia-org-4107	336	35	,	,	,
en-wikipedia-org-4107	336	36	other	other	JJ
en-wikipedia-org-4107	336	37	evidence	evidence	NN
en-wikipedia-org-4107	336	38	from	from	IN
en-wikipedia-org-4107	336	39	animal	animal	NN
en-wikipedia-org-4107	336	40	studies	study	NNS
en-wikipedia-org-4107	336	41	suggests	suggest	VBZ
en-wikipedia-org-4107	336	42	that	that	IN
en-wikipedia-org-4107	336	43	this	this	DT
en-wikipedia-org-4107	336	44	reaction	reaction	NN
en-wikipedia-org-4107	336	45	is	be	VBZ
en-wikipedia-org-4107	336	46	catalyzed	catalyze	VBN
en-wikipedia-org-4107	336	47	by	by	IN
en-wikipedia-org-4107	336	48	DBH	DBH	NNP
en-wikipedia-org-4107	336	49	in	in	IN
en-wikipedia-org-4107	336	50	synaptic	synaptic	JJ
en-wikipedia-org-4107	336	51	vesicles	vesicle	NNS
en-wikipedia-org-4107	336	52	within	within	IN
en-wikipedia-org-4107	336	53	noradrenergic	noradrenergic	JJ
en-wikipedia-org-4107	336	54	neurons	neuron	NNS
en-wikipedia-org-4107	336	55	in	in	IN
en-wikipedia-org-4107	336	56	the	the	DT
en-wikipedia-org-4107	336	57	brain	brain	NN
en-wikipedia-org-4107	336	58	.	.	.
en-wikipedia-org-4107	337	1	[	[	-LRB-
en-wikipedia-org-4107	337	2	190][191	190][191	CD
en-wikipedia-org-4107	337	3	]	]	-RRB-
en-wikipedia-org-4107	337	4	^	^	FW
en-wikipedia-org-4107	337	5	There	there	EX
en-wikipedia-org-4107	337	6	is	be	VBZ
en-wikipedia-org-4107	337	7	substantial	substantial	JJ
en-wikipedia-org-4107	337	8	variation	variation	NN
en-wikipedia-org-4107	337	9	in	in	IN
en-wikipedia-org-4107	337	10	microbiome	microbiome	JJ
en-wikipedia-org-4107	337	11	composition	composition	NN
en-wikipedia-org-4107	337	12	and	and	CC
en-wikipedia-org-4107	337	13	microbial	microbial	JJ
en-wikipedia-org-4107	337	14	concentrations	concentration	NNS
en-wikipedia-org-4107	337	15	by	by	IN
en-wikipedia-org-4107	337	16	anatomical	anatomical	JJ
en-wikipedia-org-4107	337	17	site	site	NN
en-wikipedia-org-4107	337	18	.	.	.
en-wikipedia-org-4107	338	1	[	[	-LRB-
en-wikipedia-org-4107	338	2	192][193	192][193	CD
en-wikipedia-org-4107	338	3	]	]	-RRB-
en-wikipedia-org-4107	338	4	Fluid	fluid	NN
en-wikipedia-org-4107	338	5	from	from	IN
en-wikipedia-org-4107	338	6	the	the	DT
en-wikipedia-org-4107	338	7	human	human	JJ
en-wikipedia-org-4107	338	8	colon	colon	NN
en-wikipedia-org-4107	338	9	 	  	_SP
en-wikipedia-org-4107	338	10	–	–	:
en-wikipedia-org-4107	338	11	which	which	WDT
en-wikipedia-org-4107	338	12	contains	contain	VBZ
en-wikipedia-org-4107	338	13	the	the	DT
en-wikipedia-org-4107	338	14	highest	high	JJS
en-wikipedia-org-4107	338	15	concentration	concentration	NN
en-wikipedia-org-4107	338	16	of	of	IN
en-wikipedia-org-4107	338	17	microbes	microbe	NNS
en-wikipedia-org-4107	338	18	of	of	IN
en-wikipedia-org-4107	338	19	any	any	DT
en-wikipedia-org-4107	338	20	anatomical	anatomical	JJ
en-wikipedia-org-4107	338	21	site	site	NN
en-wikipedia-org-4107	338	22	 	  	_SP
en-wikipedia-org-4107	338	23	–	–	:
en-wikipedia-org-4107	338	24	contains	contain	VBZ
en-wikipedia-org-4107	338	25	approximately	approximately	RB
en-wikipedia-org-4107	338	26	one	one	CD
en-wikipedia-org-4107	338	27	trillion	trillion	CD
en-wikipedia-org-4107	338	28	(	(	-LRB-
en-wikipedia-org-4107	338	29	10	10	CD
en-wikipedia-org-4107	338	30	^	^	SYM
en-wikipedia-org-4107	338	31	12	12	CD
en-wikipedia-org-4107	338	32	)	)	-RRB-
en-wikipedia-org-4107	338	33	bacterial	bacterial	JJ
en-wikipedia-org-4107	338	34	cells	cell	NNS
en-wikipedia-org-4107	338	35	/	/	SYM
en-wikipedia-org-4107	338	36	ml	ml	NNP
en-wikipedia-org-4107	338	37	.	.	.
en-wikipedia-org-4107	339	1	[	[	-LRB-
en-wikipedia-org-4107	339	2	192	192	CD
en-wikipedia-org-4107	339	3	]	]	-RRB-
en-wikipedia-org-4107	339	4	^	^	NN
en-wikipedia-org-4107	339	5	Enantiomers	enantiomer	NNS
en-wikipedia-org-4107	339	6	are	be	VBP
en-wikipedia-org-4107	339	7	molecules	molecule	NNS
en-wikipedia-org-4107	339	8	that	that	WDT
en-wikipedia-org-4107	339	9	are	be	VBP
en-wikipedia-org-4107	339	10	mirror	mirror	NN
en-wikipedia-org-4107	339	11	images	image	NNS
en-wikipedia-org-4107	339	12	of	of	IN
en-wikipedia-org-4107	339	13	one	one	CD
en-wikipedia-org-4107	339	14	another	another	DT
en-wikipedia-org-4107	339	15	;	;	:
en-wikipedia-org-4107	339	16	they	-PRON-	PRP
en-wikipedia-org-4107	339	17	are	be	VBP
en-wikipedia-org-4107	339	18	structurally	structurally	RB
en-wikipedia-org-4107	339	19	identical	identical	JJ
en-wikipedia-org-4107	339	20	,	,	,
en-wikipedia-org-4107	339	21	but	but	CC
en-wikipedia-org-4107	339	22	of	of	IN
en-wikipedia-org-4107	339	23	the	the	DT
en-wikipedia-org-4107	339	24	opposite	opposite	JJ
en-wikipedia-org-4107	339	25	orientation	orientation	NN
en-wikipedia-org-4107	339	26	.	.	.
en-wikipedia-org-4107	340	1	[	[	-LRB-
en-wikipedia-org-4107	340	2	25	25	CD
en-wikipedia-org-4107	340	3	]	]	-RRB-
en-wikipedia-org-4107	340	4	^	^	.
en-wikipedia-org-4107	340	5	The	the	DT
en-wikipedia-org-4107	340	6	active	active	JJ
en-wikipedia-org-4107	340	7	ingredient	ingredient	NN
en-wikipedia-org-4107	340	8	in	in	IN
en-wikipedia-org-4107	340	9	some	some	DT
en-wikipedia-org-4107	340	10	OTC	OTC	NNP
en-wikipedia-org-4107	340	11	inhalers	inhaler	NNS
en-wikipedia-org-4107	340	12	in	in	IN
en-wikipedia-org-4107	340	13	the	the	DT
en-wikipedia-org-4107	340	14	United	United	NNP
en-wikipedia-org-4107	340	15	States	States	NNP
en-wikipedia-org-4107	340	16	is	be	VBZ
en-wikipedia-org-4107	340	17	listed	list	VBN
en-wikipedia-org-4107	340	18	as	as	IN
en-wikipedia-org-4107	340	19	levmetamfetamine	levmetamfetamine	NN
en-wikipedia-org-4107	340	20	,	,	,
en-wikipedia-org-4107	340	21	the	the	DT
en-wikipedia-org-4107	340	22	INN	INN	NNP
en-wikipedia-org-4107	340	23	and	and	CC
en-wikipedia-org-4107	340	24	USAN	USAN	NNP
en-wikipedia-org-4107	340	25	of	of	IN
en-wikipedia-org-4107	340	26	levomethamphetamine	levomethamphetamine	NNP
en-wikipedia-org-4107	340	27	.	.	.
en-wikipedia-org-4107	341	1	[	[	-LRB-
en-wikipedia-org-4107	341	2	222][223	222][223	CD
en-wikipedia-org-4107	341	3	]	]	-RRB-
en-wikipedia-org-4107	341	4	^	^	.
en-wikipedia-org-4107	341	5	For	for	IN
en-wikipedia-org-4107	341	6	uniformity	uniformity	NN
en-wikipedia-org-4107	341	7	,	,	,
en-wikipedia-org-4107	341	8	molecular	molecular	JJ
en-wikipedia-org-4107	341	9	masses	masse	NNS
en-wikipedia-org-4107	341	10	were	be	VBD
en-wikipedia-org-4107	341	11	calculated	calculate	VBN
en-wikipedia-org-4107	341	12	using	use	VBG
en-wikipedia-org-4107	341	13	the	the	DT
en-wikipedia-org-4107	341	14	Lenntech	Lenntech	NNP
en-wikipedia-org-4107	341	15	Molecular	Molecular	NNP
en-wikipedia-org-4107	341	16	Weight	Weight	NNP
en-wikipedia-org-4107	341	17	Calculator[260	Calculator[260	NNP
en-wikipedia-org-4107	341	18	]	]	-RRB-
en-wikipedia-org-4107	341	19	and	and	CC
en-wikipedia-org-4107	341	20	were	be	VBD
en-wikipedia-org-4107	341	21	within	within	IN
en-wikipedia-org-4107	341	22	0.01g	0.01g	CD
en-wikipedia-org-4107	341	23	/	/	SYM
en-wikipedia-org-4107	341	24	mol	mol	NN
en-wikipedia-org-4107	341	25	of	of	IN
en-wikipedia-org-4107	341	26	published	publish	VBN
en-wikipedia-org-4107	341	27	pharmaceutical	pharmaceutical	JJ
en-wikipedia-org-4107	341	28	values	value	NNS
en-wikipedia-org-4107	341	29	.	.	.
en-wikipedia-org-4107	342	1	^	^	NFP
en-wikipedia-org-4107	342	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	342	3	base	base	NN
en-wikipedia-org-4107	342	4	percentage	percentage	NN
en-wikipedia-org-4107	342	5	=	=	SYM
en-wikipedia-org-4107	342	6	molecular	molecular	NNP
en-wikipedia-org-4107	342	7	massbase	massbase	NNP
en-wikipedia-org-4107	342	8	/	/	SYM
en-wikipedia-org-4107	342	9	molecular	molecular	JJ
en-wikipedia-org-4107	342	10	masstotal	masstotal	NN
en-wikipedia-org-4107	342	11	.	.	.
en-wikipedia-org-4107	343	1	Amphetamine	amphetamine	VB
en-wikipedia-org-4107	343	2	base	base	NN
en-wikipedia-org-4107	343	3	percentage	percentage	NN
en-wikipedia-org-4107	343	4	for	for	IN
en-wikipedia-org-4107	343	5	Adderall	Adderall	NNP
en-wikipedia-org-4107	343	6	=	=	SYM
en-wikipedia-org-4107	343	7	sum	sum	NN
en-wikipedia-org-4107	343	8	of	of	IN
en-wikipedia-org-4107	343	9	component	component	NN
en-wikipedia-org-4107	343	10	percentages	percentage	NNS
en-wikipedia-org-4107	343	11	/	/	SYM
en-wikipedia-org-4107	343	12	4	4	CD
en-wikipedia-org-4107	343	13	.	.	.
en-wikipedia-org-4107	344	1	^	^	NNP
en-wikipedia-org-4107	344	2	dose	dose	NNP
en-wikipedia-org-4107	344	3	=	=	NFP
en-wikipedia-org-4107	344	4	(	(	-LRB-
en-wikipedia-org-4107	344	5	1	1	CD
en-wikipedia-org-4107	344	6	/	/	SYM
en-wikipedia-org-4107	344	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	344	8	base	base	NN
en-wikipedia-org-4107	344	9	percentage	percentage	NN
en-wikipedia-org-4107	344	10	)	)	-RRB-
en-wikipedia-org-4107	344	11	×	×	ADD
en-wikipedia-org-4107	344	12	scaling	scale	VBG
en-wikipedia-org-4107	344	13	factor	factor	NN
en-wikipedia-org-4107	344	14	=	=	NFP
en-wikipedia-org-4107	344	15	(	(	-LRB-
en-wikipedia-org-4107	344	16	molecular	molecular	JJ
en-wikipedia-org-4107	344	17	masstotal	masstotal	NNP
en-wikipedia-org-4107	344	18	/	/	SYM
en-wikipedia-org-4107	344	19	molecular	molecular	JJ
en-wikipedia-org-4107	344	20	massbase	massbase	NN
en-wikipedia-org-4107	344	21	)	)	-RRB-
en-wikipedia-org-4107	344	22	×	×	ADD
en-wikipedia-org-4107	344	23	scaling	scale	VBG
en-wikipedia-org-4107	344	24	factor	factor	NN
en-wikipedia-org-4107	344	25	.	.	.
en-wikipedia-org-4107	345	1	The	the	DT
en-wikipedia-org-4107	345	2	values	value	NNS
en-wikipedia-org-4107	345	3	in	in	IN
en-wikipedia-org-4107	345	4	this	this	DT
en-wikipedia-org-4107	345	5	column	column	NN
en-wikipedia-org-4107	345	6	were	be	VBD
en-wikipedia-org-4107	345	7	scaled	scale	VBN
en-wikipedia-org-4107	345	8	to	to	IN
en-wikipedia-org-4107	345	9	a	a	DT
en-wikipedia-org-4107	345	10	30	30	CD
en-wikipedia-org-4107	345	11	 	  	_SP
en-wikipedia-org-4107	345	12	mg	mg	NNP
en-wikipedia-org-4107	345	13	dose	dose	NN
en-wikipedia-org-4107	345	14	of	of	IN
en-wikipedia-org-4107	345	15	dextroamphetamine	dextroamphetamine	JJ
en-wikipedia-org-4107	345	16	sulfate	sulfate	NN
en-wikipedia-org-4107	345	17	.	.	.
en-wikipedia-org-4107	346	1	Due	due	IN
en-wikipedia-org-4107	346	2	to	to	IN
en-wikipedia-org-4107	346	3	pharmacological	pharmacological	JJ
en-wikipedia-org-4107	346	4	differences	difference	NNS
en-wikipedia-org-4107	346	5	between	between	IN
en-wikipedia-org-4107	346	6	these	these	DT
en-wikipedia-org-4107	346	7	medications	medication	NNS
en-wikipedia-org-4107	346	8	(	(	-LRB-
en-wikipedia-org-4107	346	9	e.g.	e.g.	RB
en-wikipedia-org-4107	346	10	,	,	,
en-wikipedia-org-4107	346	11	differences	difference	NNS
en-wikipedia-org-4107	346	12	in	in	IN
en-wikipedia-org-4107	346	13	the	the	DT
en-wikipedia-org-4107	346	14	release	release	NN
en-wikipedia-org-4107	346	15	,	,	,
en-wikipedia-org-4107	346	16	absorption	absorption	NN
en-wikipedia-org-4107	346	17	,	,	,
en-wikipedia-org-4107	346	18	conversion	conversion	NN
en-wikipedia-org-4107	346	19	,	,	,
en-wikipedia-org-4107	346	20	concentration	concentration	NN
en-wikipedia-org-4107	346	21	,	,	,
en-wikipedia-org-4107	346	22	differing	differing	JJ
en-wikipedia-org-4107	346	23	effects	effect	NNS
en-wikipedia-org-4107	346	24	of	of	IN
en-wikipedia-org-4107	346	25	enantiomers	enantiomer	NNS
en-wikipedia-org-4107	346	26	,	,	,
en-wikipedia-org-4107	346	27	half	half	JJ
en-wikipedia-org-4107	346	28	-	-	HYPH
en-wikipedia-org-4107	346	29	life	life	NN
en-wikipedia-org-4107	346	30	,	,	,
en-wikipedia-org-4107	346	31	etc	etc	FW
en-wikipedia-org-4107	346	32	.	.	.
en-wikipedia-org-4107	347	1	)	)	-RRB-
en-wikipedia-org-4107	347	2	,	,	,
en-wikipedia-org-4107	347	3	the	the	DT
en-wikipedia-org-4107	347	4	listed	list	VBN
en-wikipedia-org-4107	347	5	values	value	NNS
en-wikipedia-org-4107	347	6	should	should	MD
en-wikipedia-org-4107	347	7	not	not	RB
en-wikipedia-org-4107	347	8	be	be	VB
en-wikipedia-org-4107	347	9	considered	consider	VBN
en-wikipedia-org-4107	347	10	equipotent	equipotent	JJ
en-wikipedia-org-4107	347	11	doses	dose	NNS
en-wikipedia-org-4107	347	12	.	.	.
en-wikipedia-org-4107	348	1	^	^	NFP
en-wikipedia-org-4107	348	2	This	this	DT
en-wikipedia-org-4107	348	3	product	product	NN
en-wikipedia-org-4107	348	4	(	(	-LRB-
en-wikipedia-org-4107	348	5	Dyanavel	Dyanavel	NNP
en-wikipedia-org-4107	348	6	XR	XR	NNP
en-wikipedia-org-4107	348	7	)	)	-RRB-
en-wikipedia-org-4107	348	8	is	be	VBZ
en-wikipedia-org-4107	348	9	an	an	DT
en-wikipedia-org-4107	348	10	oral	oral	JJ
en-wikipedia-org-4107	348	11	suspension	suspension	NN
en-wikipedia-org-4107	348	12	(	(	-LRB-
en-wikipedia-org-4107	348	13	i.e.	i.e.	FW
en-wikipedia-org-4107	348	14	,	,	,
en-wikipedia-org-4107	348	15	a	a	DT
en-wikipedia-org-4107	348	16	drug	drug	NN
en-wikipedia-org-4107	348	17	that	that	WDT
en-wikipedia-org-4107	348	18	is	be	VBZ
en-wikipedia-org-4107	348	19	suspended	suspend	VBN
en-wikipedia-org-4107	348	20	in	in	IN
en-wikipedia-org-4107	348	21	a	a	DT
en-wikipedia-org-4107	348	22	liquid	liquid	NN
en-wikipedia-org-4107	348	23	and	and	CC
en-wikipedia-org-4107	348	24	taken	take	VBN
en-wikipedia-org-4107	348	25	by	by	IN
en-wikipedia-org-4107	348	26	mouth	mouth	NN
en-wikipedia-org-4107	348	27	)	)	-RRB-
en-wikipedia-org-4107	348	28	that	that	WDT
en-wikipedia-org-4107	348	29	contains	contain	VBZ
en-wikipedia-org-4107	348	30	2.5	2.5	CD
en-wikipedia-org-4107	348	31	 	  	_SP
en-wikipedia-org-4107	348	32	mg	mg	NNP
en-wikipedia-org-4107	348	33	/	/	SYM
en-wikipedia-org-4107	348	34	mL	mL	NNP
en-wikipedia-org-4107	348	35	of	of	IN
en-wikipedia-org-4107	348	36	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	348	37	base	base	NN
en-wikipedia-org-4107	348	38	.	.	.
en-wikipedia-org-4107	349	1	[	[	-LRB-
en-wikipedia-org-4107	349	2	88	88	CD
en-wikipedia-org-4107	349	3	]	]	-RRB-
en-wikipedia-org-4107	349	4	The	the	DT
en-wikipedia-org-4107	349	5	product	product	NN
en-wikipedia-org-4107	349	6	uses	use	VBZ
en-wikipedia-org-4107	349	7	an	an	DT
en-wikipedia-org-4107	349	8	ion	ion	NN
en-wikipedia-org-4107	349	9	exchange	exchange	NN
en-wikipedia-org-4107	349	10	resin	resin	NN
en-wikipedia-org-4107	349	11	to	to	TO
en-wikipedia-org-4107	349	12	achieve	achieve	VB
en-wikipedia-org-4107	349	13	extended	extended	JJ
en-wikipedia-org-4107	349	14	release	release	NN
en-wikipedia-org-4107	349	15	of	of	IN
en-wikipedia-org-4107	349	16	the	the	DT
en-wikipedia-org-4107	349	17	amphetamine	amphetamine	NN
en-wikipedia-org-4107	349	18	base	base	NN
en-wikipedia-org-4107	349	19	.	.	.
en-wikipedia-org-4107	350	1	[	[	-LRB-
en-wikipedia-org-4107	350	2	88	88	CD
en-wikipedia-org-4107	350	3	]	]	-RRB-
en-wikipedia-org-4107	350	4	Image	image	NN
en-wikipedia-org-4107	350	5	legend	legend	NN
en-wikipedia-org-4107	350	6	^	^	.
en-wikipedia-org-4107	350	7	  	  	_SP
en-wikipedia-org-4107	350	8	Ion	Ion	NNP
en-wikipedia-org-4107	350	9	channel	channel	NN
en-wikipedia-org-4107	350	10	  	  	_SP
en-wikipedia-org-4107	350	11	G	G	NNP
en-wikipedia-org-4107	350	12	proteins	protein	NNS
en-wikipedia-org-4107	350	13	&	&	CC
en-wikipedia-org-4107	350	14	linked	link	VBN
en-wikipedia-org-4107	350	15	receptors	receptor	NNS
en-wikipedia-org-4107	350	16	  	  	_SP
en-wikipedia-org-4107	350	17	(	(	-LRB-
en-wikipedia-org-4107	350	18	Text	Text	NNP
en-wikipedia-org-4107	350	19	color	color	NN
en-wikipedia-org-4107	350	20	)	)	-RRB-
en-wikipedia-org-4107	350	21	Transcription	transcription	NN
en-wikipedia-org-4107	350	22	factors	factor	NNS
en-wikipedia-org-4107	350	23	Reference	Reference	NNP
en-wikipedia-org-4107	350	24	notes	note	VBZ
en-wikipedia-org-4107	350	25	^	^	VBP
en-wikipedia-org-4107	350	26	[	[	-LRB-
en-wikipedia-org-4107	350	27	3][18][26][27][28][29][30][31][32][33][34][35	3][18][26][27][28][29][30][31][32][33][34][35	NN
en-wikipedia-org-4107	350	28	]	]	-RRB-
en-wikipedia-org-4107	350	29	^	^	NN
en-wikipedia-org-4107	350	30	[	[	-LRB-
en-wikipedia-org-4107	350	31	3][11][26][29][35][37][38	3][11][26][29][35][37][38	CD
en-wikipedia-org-4107	350	32	]	]	-RRB-
en-wikipedia-org-4107	350	33	^	^	NN
en-wikipedia-org-4107	350	34	[	[	-LRB-
en-wikipedia-org-4107	350	35	11][26][27][28][32][39][40][41][42][43][44][45	11][26][27][28][32][39][40][41][42][43][44][45	CD
en-wikipedia-org-4107	350	36	]	]	-RRB-
en-wikipedia-org-4107	350	37	^	^	NN
en-wikipedia-org-4107	350	38	[	[	-LRB-
en-wikipedia-org-4107	350	39	46][47][48	46][47][48	CD
en-wikipedia-org-4107	350	40	]	]	-RRB-
en-wikipedia-org-4107	350	41	^	^	NN
en-wikipedia-org-4107	350	42	[	[	-LRB-
en-wikipedia-org-4107	350	43	2][28][39][87][88][89	2][28][39][87][88][89	NN
en-wikipedia-org-4107	350	44	]	]	-RRB-
en-wikipedia-org-4107	350	45	^	^	FW
en-wikipedia-org-4107	350	46	[	[	-LRB-
en-wikipedia-org-4107	350	47	90][91][92][93	90][91][92][93	CD
en-wikipedia-org-4107	350	48	]	]	-RRB-
en-wikipedia-org-4107	350	49	^	^	NN
en-wikipedia-org-4107	350	50	[	[	-LRB-
en-wikipedia-org-4107	350	51	28][84][90][92	28][84][90][92	CD
en-wikipedia-org-4107	350	52	]	]	-RRB-
en-wikipedia-org-4107	350	53	^	^	NN
en-wikipedia-org-4107	350	54	[	[	-LRB-
en-wikipedia-org-4107	350	55	32][28][39][94	32][28][39][94	CD
en-wikipedia-org-4107	350	56	]	]	-RRB-
en-wikipedia-org-4107	350	57	^	^	FW
en-wikipedia-org-4107	350	58	a	a	DT
en-wikipedia-org-4107	350	59	b	b	NN
en-wikipedia-org-4107	350	60	[	[	-LRB-
en-wikipedia-org-4107	350	61	110][111][112][113][132	110][111][112][113][132	CD
en-wikipedia-org-4107	350	62	]	]	-RRB-
en-wikipedia-org-4107	350	63	^	^	NN
en-wikipedia-org-4107	350	64	[	[	-LRB-
en-wikipedia-org-4107	350	65	108][110][109][117][118	108][110][109][117][118	CD
en-wikipedia-org-4107	350	66	]	]	-RRB-
en-wikipedia-org-4107	350	67	^	^	FW
en-wikipedia-org-4107	350	68	[	[	-LRB-
en-wikipedia-org-4107	350	69	109][120][121][122	109][120][121][122	CD
en-wikipedia-org-4107	350	70	]	]	-RRB-
en-wikipedia-org-4107	350	71	^	^	NN
en-wikipedia-org-4107	350	72	[	[	-LRB-
en-wikipedia-org-4107	350	73	24][28][39][136][138	24][28][39][136][138	CD
en-wikipedia-org-4107	350	74	]	]	-RRB-
en-wikipedia-org-4107	350	75	^	^	NNP
en-wikipedia-org-4107	350	76	[	[	-LRB-
en-wikipedia-org-4107	350	77	50][140][143][144	50][140][143][144	CD
en-wikipedia-org-4107	350	78	]	]	-RRB-
en-wikipedia-org-4107	350	79	^	^	FW
en-wikipedia-org-4107	350	80	a	a	DT
en-wikipedia-org-4107	350	81	b	b	NN
en-wikipedia-org-4107	350	82	[	[	-LRB-
en-wikipedia-org-4107	350	83	151][155][159][160][161][162][163	151][155][159][160][161][162][163	NN
en-wikipedia-org-4107	350	84	]	]	-RRB-
en-wikipedia-org-4107	350	85	^	^	NN
en-wikipedia-org-4107	350	86	[	[	-LRB-
en-wikipedia-org-4107	350	87	37][151][159][160][164][169	37][151][159][160][164][169	CD
en-wikipedia-org-4107	350	88	]	]	-RRB-
en-wikipedia-org-4107	350	89	^	^	FW
en-wikipedia-org-4107	350	90	a	a	DT
en-wikipedia-org-4107	350	91	b	b	NN
en-wikipedia-org-4107	350	92	[	[	-LRB-
en-wikipedia-org-4107	350	93	6][14][15][16][17][7][187][188	6][14][15][16][17][7][187][188	NN
en-wikipedia-org-4107	350	94	]	]	-RRB-
en-wikipedia-org-4107	350	95	^	^	FW
en-wikipedia-org-4107	350	96	[	[	-LRB-
en-wikipedia-org-4107	350	97	27][217][218][219	27][217][218][219	CD
en-wikipedia-org-4107	350	98	]	]	-RRB-
en-wikipedia-org-4107	350	99	References	reference	NNS
en-wikipedia-org-4107	350	100	^	^	NN
en-wikipedia-org-4107	350	101	"	"	``
en-wikipedia-org-4107	350	102	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	350	103	/	/	SYM
en-wikipedia-org-4107	350	104	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	350	105	Use	Use	NNP
en-wikipedia-org-4107	350	106	During	During	NNP
en-wikipedia-org-4107	350	107	Pregnancy	Pregnancy	NNP
en-wikipedia-org-4107	350	108	"	"	''
en-wikipedia-org-4107	350	109	.	.	.
en-wikipedia-org-4107	351	1	Drugs.com	Drugs.com	NNP
en-wikipedia-org-4107	351	2	.	.	.
en-wikipedia-org-4107	352	1	23	23	CD
en-wikipedia-org-4107	352	2	September	September	NNP
en-wikipedia-org-4107	352	3	2019	2019	CD
en-wikipedia-org-4107	352	4	.	.	.
en-wikipedia-org-4107	353	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	353	2	22	22	CD
en-wikipedia-org-4107	353	3	December	December	NNP
en-wikipedia-org-4107	353	4	2019	2019	CD
en-wikipedia-org-4107	353	5	.	.	.
en-wikipedia-org-4107	354	1	^	^	NNP
en-wikipedia-org-4107	354	2	a	a	DT
en-wikipedia-org-4107	354	3	b	b	NNP
en-wikipedia-org-4107	354	4	c	c	NNP
en-wikipedia-org-4107	354	5	d	d	NNP
en-wikipedia-org-4107	354	6	e	e	NNP
en-wikipedia-org-4107	354	7	f	f	NNP
en-wikipedia-org-4107	354	8	g	g	NNP
en-wikipedia-org-4107	354	9	h	h	NNP
en-wikipedia-org-4107	354	10	i	i	NN
en-wikipedia-org-4107	354	11	j	j	DT
en-wikipedia-org-4107	354	12	Stahl	Stahl	NNP
en-wikipedia-org-4107	354	13	SM	SM	NNP
en-wikipedia-org-4107	354	14	(	(	-LRB-
en-wikipedia-org-4107	354	15	March	March	NNP
en-wikipedia-org-4107	354	16	2017	2017	CD
en-wikipedia-org-4107	354	17	)	)	-RRB-
en-wikipedia-org-4107	354	18	.	.	.
en-wikipedia-org-4107	355	1	"	"	``
en-wikipedia-org-4107	355	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	355	3	(	(	-LRB-
en-wikipedia-org-4107	355	4	D	D	NNP
en-wikipedia-org-4107	355	5	,	,	,
en-wikipedia-org-4107	355	6	L	l	NN
en-wikipedia-org-4107	355	7	)	)	-RRB-
en-wikipedia-org-4107	355	8	"	"	''
en-wikipedia-org-4107	355	9	.	.	.
en-wikipedia-org-4107	356	1	Prescriber	Prescriber	NNP
en-wikipedia-org-4107	356	2	's	's	POS
en-wikipedia-org-4107	356	3	Guide	Guide	NNP
en-wikipedia-org-4107	356	4	:	:	:
en-wikipedia-org-4107	356	5	Stahl	Stahl	NNPS
en-wikipedia-org-4107	356	6	's	's	POS
en-wikipedia-org-4107	356	7	Essential	Essential	NNP
en-wikipedia-org-4107	356	8	Psychopharmacology	Psychopharmacology	NNP
en-wikipedia-org-4107	356	9	(	(	-LRB-
en-wikipedia-org-4107	356	10	6th	6th	JJ
en-wikipedia-org-4107	356	11	ed	ed	NNP
en-wikipedia-org-4107	356	12	.	.	.
en-wikipedia-org-4107	356	13	)	)	-RRB-
en-wikipedia-org-4107	356	14	.	.	.
en-wikipedia-org-4107	357	1	Cambridge	Cambridge	NNP
en-wikipedia-org-4107	357	2	,	,	,
en-wikipedia-org-4107	357	3	United	United	NNP
en-wikipedia-org-4107	357	4	Kingdom	Kingdom	NNP
en-wikipedia-org-4107	357	5	:	:	:
en-wikipedia-org-4107	357	6	Cambridge	Cambridge	NNP
en-wikipedia-org-4107	357	7	University	University	NNP
en-wikipedia-org-4107	357	8	Press	Press	NNP
en-wikipedia-org-4107	357	9	.	.	.
en-wikipedia-org-4107	358	1	pp	pp	NNP
en-wikipedia-org-4107	358	2	.	.	.
en-wikipedia-org-4107	359	1	45–51	45–51	LS
en-wikipedia-org-4107	359	2	.	.	.
en-wikipedia-org-4107	360	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	360	2	 	  	_SP
en-wikipedia-org-4107	360	3	9781108228749	9781108228749	CD
en-wikipedia-org-4107	360	4	.	.	.
en-wikipedia-org-4107	361	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	361	2	5	5	CD
en-wikipedia-org-4107	361	3	August	August	NNP
en-wikipedia-org-4107	361	4	2017	2017	CD
en-wikipedia-org-4107	361	5	.	.	.
en-wikipedia-org-4107	362	1	^	^	NNP
en-wikipedia-org-4107	362	2	a	a	DT
en-wikipedia-org-4107	362	3	b	b	NNP
en-wikipedia-org-4107	362	4	c	c	NNP
en-wikipedia-org-4107	362	5	d	d	NNP
en-wikipedia-org-4107	362	6	e	e	NNP
en-wikipedia-org-4107	362	7	f	f	NNP
en-wikipedia-org-4107	362	8	g	g	NNP
en-wikipedia-org-4107	362	9	h	h	NNP
en-wikipedia-org-4107	362	10	i	i	NN
en-wikipedia-org-4107	362	11	j	j	NNP
en-wikipedia-org-4107	362	12	k	k	NNP
en-wikipedia-org-4107	362	13	l	l	NNP
en-wikipedia-org-4107	362	14	m	m	NNP
en-wikipedia-org-4107	362	15	Heal	Heal	NNP
en-wikipedia-org-4107	362	16	DJ	DJ	NNP
en-wikipedia-org-4107	362	17	,	,	,
en-wikipedia-org-4107	362	18	Smith	Smith	NNP
en-wikipedia-org-4107	362	19	SL	SL	NNP
en-wikipedia-org-4107	362	20	,	,	,
en-wikipedia-org-4107	362	21	Gosden	Gosden	NNP
en-wikipedia-org-4107	362	22	J	J	NNP
en-wikipedia-org-4107	362	23	,	,	,
en-wikipedia-org-4107	362	24	Nutt	Nutt	NNP
en-wikipedia-org-4107	362	25	DJ	DJ	NNP
en-wikipedia-org-4107	362	26	(	(	-LRB-
en-wikipedia-org-4107	362	27	June	June	NNP
en-wikipedia-org-4107	362	28	2013	2013	CD
en-wikipedia-org-4107	362	29	)	)	-RRB-
en-wikipedia-org-4107	362	30	.	.	.
en-wikipedia-org-4107	363	1	"	"	``
en-wikipedia-org-4107	363	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	363	3	,	,	,
en-wikipedia-org-4107	363	4	past	past	NN
en-wikipedia-org-4107	363	5	and	and	CC
en-wikipedia-org-4107	363	6	present	present	NN
en-wikipedia-org-4107	363	7	–	–	:
en-wikipedia-org-4107	363	8	a	a	DT
en-wikipedia-org-4107	363	9	pharmacological	pharmacological	JJ
en-wikipedia-org-4107	363	10	and	and	CC
en-wikipedia-org-4107	363	11	clinical	clinical	JJ
en-wikipedia-org-4107	363	12	perspective	perspective	NN
en-wikipedia-org-4107	363	13	"	"	''
en-wikipedia-org-4107	363	14	.	.	.
en-wikipedia-org-4107	364	1	Journal	Journal	NNP
en-wikipedia-org-4107	364	2	of	of	IN
en-wikipedia-org-4107	364	3	Psychopharmacology	Psychopharmacology	NNP
en-wikipedia-org-4107	364	4	.	.	.
en-wikipedia-org-4107	365	1	27	27	CD
en-wikipedia-org-4107	365	2	(	(	-LRB-
en-wikipedia-org-4107	365	3	6	6	CD
en-wikipedia-org-4107	365	4	)	)	-RRB-
en-wikipedia-org-4107	365	5	:	:	:
en-wikipedia-org-4107	365	6	479–496	479–496	CD
en-wikipedia-org-4107	365	7	.	.	.
en-wikipedia-org-4107	366	1	doi:10.1177/0269881113482532	doi:10.1177/0269881113482532	RB
en-wikipedia-org-4107	366	2	.	.	.
en-wikipedia-org-4107	367	1	PMC	PMC	NNP
en-wikipedia-org-4107	367	2	 	  	_SP
en-wikipedia-org-4107	367	3	3666194	3666194	CD
en-wikipedia-org-4107	367	4	.	.	.
en-wikipedia-org-4107	368	1	PMID	PMID	NNP
en-wikipedia-org-4107	368	2	 	  	_SP
en-wikipedia-org-4107	368	3	23539642	23539642	CD
en-wikipedia-org-4107	368	4	.	.	.
en-wikipedia-org-4107	369	1	The	the	DT
en-wikipedia-org-4107	369	2	intravenous	intravenous	JJ
en-wikipedia-org-4107	369	3	use	use	NN
en-wikipedia-org-4107	369	4	of	of	IN
en-wikipedia-org-4107	369	5	d	d	NN
en-wikipedia-org-4107	369	6	-	-	HYPH
en-wikipedia-org-4107	369	7	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	369	8	and	and	CC
en-wikipedia-org-4107	369	9	other	other	JJ
en-wikipedia-org-4107	369	10	stimulants	stimulant	NNS
en-wikipedia-org-4107	369	11	still	still	RB
en-wikipedia-org-4107	369	12	pose	pose	VBP
en-wikipedia-org-4107	369	13	major	major	JJ
en-wikipedia-org-4107	369	14	safety	safety	NN
en-wikipedia-org-4107	369	15	risks	risk	NNS
en-wikipedia-org-4107	369	16	to	to	IN
en-wikipedia-org-4107	369	17	the	the	DT
en-wikipedia-org-4107	369	18	individuals	individual	NNS
en-wikipedia-org-4107	369	19	indulging	indulge	VBG
en-wikipedia-org-4107	369	20	in	in	IN
en-wikipedia-org-4107	369	21	this	this	DT
en-wikipedia-org-4107	369	22	practice	practice	NN
en-wikipedia-org-4107	369	23	.	.	.
en-wikipedia-org-4107	370	1	Some	some	DT
en-wikipedia-org-4107	370	2	of	of	IN
en-wikipedia-org-4107	370	3	this	this	DT
en-wikipedia-org-4107	370	4	intravenous	intravenous	JJ
en-wikipedia-org-4107	370	5	abuse	abuse	NN
en-wikipedia-org-4107	370	6	is	be	VBZ
en-wikipedia-org-4107	370	7	derived	derive	VBN
en-wikipedia-org-4107	370	8	from	from	IN
en-wikipedia-org-4107	370	9	the	the	DT
en-wikipedia-org-4107	370	10	diversion	diversion	NN
en-wikipedia-org-4107	370	11	of	of	IN
en-wikipedia-org-4107	370	12	ampoules	ampoule	NNS
en-wikipedia-org-4107	370	13	of	of	IN
en-wikipedia-org-4107	370	14	d	d	NN
en-wikipedia-org-4107	370	15	-	-	HYPH
en-wikipedia-org-4107	370	16	amphetamine	amphetamine	NN
en-wikipedia-org-4107	370	17	,	,	,
en-wikipedia-org-4107	370	18	which	which	WDT
en-wikipedia-org-4107	370	19	are	be	VBP
en-wikipedia-org-4107	370	20	still	still	RB
en-wikipedia-org-4107	370	21	occasionally	occasionally	RB
en-wikipedia-org-4107	370	22	prescribed	prescribe	VBN
en-wikipedia-org-4107	370	23	in	in	IN
en-wikipedia-org-4107	370	24	the	the	DT
en-wikipedia-org-4107	370	25	UK	UK	NNP
en-wikipedia-org-4107	370	26	for	for	IN
en-wikipedia-org-4107	370	27	the	the	DT
en-wikipedia-org-4107	370	28	control	control	NN
en-wikipedia-org-4107	370	29	of	of	IN
en-wikipedia-org-4107	370	30	severe	severe	JJ
en-wikipedia-org-4107	370	31	narcolepsy	narcolepsy	NN
en-wikipedia-org-4107	370	32	and	and	CC
en-wikipedia-org-4107	370	33	other	other	JJ
en-wikipedia-org-4107	370	34	disorders	disorder	NNS
en-wikipedia-org-4107	370	35	of	of	IN
en-wikipedia-org-4107	370	36	excessive	excessive	JJ
en-wikipedia-org-4107	370	37	sedation	sedation	NN
en-wikipedia-org-4107	370	38	.	.	.
en-wikipedia-org-4107	371	1	...	...	:
en-wikipedia-org-4107	371	2	For	for	IN
en-wikipedia-org-4107	371	3	these	these	DT
en-wikipedia-org-4107	371	4	reasons	reason	NNS
en-wikipedia-org-4107	371	5	,	,	,
en-wikipedia-org-4107	371	6	observations	observation	NNS
en-wikipedia-org-4107	371	7	of	of	IN
en-wikipedia-org-4107	371	8	dependence	dependence	NN
en-wikipedia-org-4107	371	9	and	and	CC
en-wikipedia-org-4107	371	10	abuse	abuse	NN
en-wikipedia-org-4107	371	11	of	of	IN
en-wikipedia-org-4107	371	12	prescription	prescription	NN
en-wikipedia-org-4107	371	13	d	d	NNP
en-wikipedia-org-4107	371	14	-	-	HYPH
en-wikipedia-org-4107	371	15	amphetamine	amphetamine	NN
en-wikipedia-org-4107	371	16	are	be	VBP
en-wikipedia-org-4107	371	17	rare	rare	JJ
en-wikipedia-org-4107	371	18	in	in	IN
en-wikipedia-org-4107	371	19	clinical	clinical	JJ
en-wikipedia-org-4107	371	20	practice	practice	NN
en-wikipedia-org-4107	371	21	,	,	,
en-wikipedia-org-4107	371	22	and	and	CC
en-wikipedia-org-4107	371	23	this	this	DT
en-wikipedia-org-4107	371	24	stimulant	stimulant	NN
en-wikipedia-org-4107	371	25	can	can	MD
en-wikipedia-org-4107	371	26	even	even	RB
en-wikipedia-org-4107	371	27	be	be	VB
en-wikipedia-org-4107	371	28	prescribed	prescribe	VBN
en-wikipedia-org-4107	371	29	to	to	IN
en-wikipedia-org-4107	371	30	people	people	NNS
en-wikipedia-org-4107	371	31	with	with	IN
en-wikipedia-org-4107	371	32	a	a	DT
en-wikipedia-org-4107	371	33	history	history	NN
en-wikipedia-org-4107	371	34	of	of	IN
en-wikipedia-org-4107	371	35	drug	drug	NN
en-wikipedia-org-4107	371	36	abuse	abuse	NN
en-wikipedia-org-4107	371	37	provided	provide	VBD
en-wikipedia-org-4107	371	38	certain	certain	JJ
en-wikipedia-org-4107	371	39	controls	control	NNS
en-wikipedia-org-4107	371	40	,	,	,
en-wikipedia-org-4107	371	41	such	such	JJ
en-wikipedia-org-4107	371	42	as	as	IN
en-wikipedia-org-4107	371	43	daily	daily	JJ
en-wikipedia-org-4107	371	44	pick	pick	NN
en-wikipedia-org-4107	371	45	-	-	HYPH
en-wikipedia-org-4107	371	46	ups	up	NNS
en-wikipedia-org-4107	371	47	of	of	IN
en-wikipedia-org-4107	371	48	prescriptions	prescription	NNS
en-wikipedia-org-4107	371	49	,	,	,
en-wikipedia-org-4107	371	50	are	be	VBP
en-wikipedia-org-4107	371	51	put	put	VBN
en-wikipedia-org-4107	371	52	in	in	IN
en-wikipedia-org-4107	371	53	place	place	NN
en-wikipedia-org-4107	371	54	(	(	-LRB-
en-wikipedia-org-4107	371	55	Jasinski	Jasinski	NNP
en-wikipedia-org-4107	371	56	and	and	CC
en-wikipedia-org-4107	371	57	Krishnan	Krishnan	NNP
en-wikipedia-org-4107	371	58	,	,	,
en-wikipedia-org-4107	371	59	2009b	2009b	CD
en-wikipedia-org-4107	371	60	)	)	-RRB-
en-wikipedia-org-4107	371	61	.	.	.
en-wikipedia-org-4107	372	1	^	^	NNP
en-wikipedia-org-4107	372	2	a	a	DT
en-wikipedia-org-4107	372	3	b	b	NNP
en-wikipedia-org-4107	372	4	"	"	``
en-wikipedia-org-4107	372	5	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	372	6	"	"	''
en-wikipedia-org-4107	372	7	.	.	.
en-wikipedia-org-4107	373	1	Dextroamphetamine	dextroamphetamine	JJ
en-wikipedia-org-4107	373	2	.	.	.
en-wikipedia-org-4107	374	1	DrugBank	DrugBank	NNP
en-wikipedia-org-4107	374	2	.	.	.
en-wikipedia-org-4107	375	1	University	University	NNP
en-wikipedia-org-4107	375	2	of	of	IN
en-wikipedia-org-4107	375	3	Alberta	Alberta	NNP
en-wikipedia-org-4107	375	4	.	.	.
en-wikipedia-org-4107	376	1	8	8	CD
en-wikipedia-org-4107	376	2	February	February	NNP
en-wikipedia-org-4107	376	3	2013	2013	CD
en-wikipedia-org-4107	376	4	.	.	.
en-wikipedia-org-4107	377	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	377	2	5	5	CD
en-wikipedia-org-4107	377	3	November	November	NNP
en-wikipedia-org-4107	377	4	2013	2013	CD
en-wikipedia-org-4107	377	5	.	.	.
en-wikipedia-org-4107	378	1	^	^	NNP
en-wikipedia-org-4107	378	2	a	a	DT
en-wikipedia-org-4107	378	3	b	b	NNP
en-wikipedia-org-4107	378	4	c	c	NN
en-wikipedia-org-4107	378	5	d	d	NN
en-wikipedia-org-4107	378	6	e	e	NNP
en-wikipedia-org-4107	378	7	"	"	``
en-wikipedia-org-4107	378	8	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	378	9	"	"	''
en-wikipedia-org-4107	378	10	.	.	.
en-wikipedia-org-4107	379	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	379	2	.	.	.
en-wikipedia-org-4107	380	1	DrugBank	DrugBank	NNP
en-wikipedia-org-4107	380	2	.	.	.
en-wikipedia-org-4107	381	1	University	University	NNP
en-wikipedia-org-4107	381	2	of	of	IN
en-wikipedia-org-4107	381	3	Alberta	Alberta	NNP
en-wikipedia-org-4107	381	4	.	.	.
en-wikipedia-org-4107	382	1	8	8	CD
en-wikipedia-org-4107	382	2	February	February	NNP
en-wikipedia-org-4107	382	3	2013	2013	CD
en-wikipedia-org-4107	382	4	.	.	.
en-wikipedia-org-4107	383	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	383	2	5	5	CD
en-wikipedia-org-4107	383	3	November	November	NNP
en-wikipedia-org-4107	383	4	2013	2013	CD
en-wikipedia-org-4107	383	5	.	.	.
en-wikipedia-org-4107	384	1	^	^	NNP
en-wikipedia-org-4107	384	2	a	a	DT
en-wikipedia-org-4107	384	3	b	b	NNP
en-wikipedia-org-4107	384	4	c	c	NNP
en-wikipedia-org-4107	384	5	d	d	NNP
en-wikipedia-org-4107	384	6	e	e	NNP
en-wikipedia-org-4107	384	7	f	f	NNP
en-wikipedia-org-4107	384	8	g	g	NNP
en-wikipedia-org-4107	384	9	h	h	NNP
en-wikipedia-org-4107	384	10	i	i	NN
en-wikipedia-org-4107	384	11	j	j	NNP
en-wikipedia-org-4107	384	12	k	k	NNP
en-wikipedia-org-4107	384	13	l	l	NNP
en-wikipedia-org-4107	384	14	m	m	NNP
en-wikipedia-org-4107	384	15	n	n	CC
en-wikipedia-org-4107	384	16	o	o	NNP
en-wikipedia-org-4107	384	17	p	p	NN
en-wikipedia-org-4107	384	18	q	q	NNP
en-wikipedia-org-4107	384	19	r	r	NNP
en-wikipedia-org-4107	384	20	s	s	POS
en-wikipedia-org-4107	384	21	"	"	``
en-wikipedia-org-4107	384	22	Adderall	Adderall	NNP
en-wikipedia-org-4107	384	23	XR	XR	NNP
en-wikipedia-org-4107	384	24	Prescribing	Prescribing	NNP
en-wikipedia-org-4107	384	25	Information	Information	NNP
en-wikipedia-org-4107	384	26	"	"	''
en-wikipedia-org-4107	384	27	(	(	-LRB-
en-wikipedia-org-4107	384	28	PDF	PDF	NNP
en-wikipedia-org-4107	384	29	)	)	-RRB-
en-wikipedia-org-4107	384	30	.	.	.
en-wikipedia-org-4107	385	1	United	United	NNP
en-wikipedia-org-4107	385	2	States	States	NNP
en-wikipedia-org-4107	385	3	Food	Food	NNP
en-wikipedia-org-4107	385	4	and	and	CC
en-wikipedia-org-4107	385	5	Drug	Drug	NNP
en-wikipedia-org-4107	385	6	Administration	Administration	NNP
en-wikipedia-org-4107	385	7	.	.	.
en-wikipedia-org-4107	386	1	Shire	Shire	NNP
en-wikipedia-org-4107	386	2	US	US	NNP
en-wikipedia-org-4107	386	3	Inc.	Inc.	NNP
en-wikipedia-org-4107	386	4	December	December	NNP
en-wikipedia-org-4107	386	5	2013	2013	CD
en-wikipedia-org-4107	386	6	.	.	.
en-wikipedia-org-4107	386	7	pp	pp	NNP
en-wikipedia-org-4107	386	8	.	.	.
en-wikipedia-org-4107	387	1	12–13	12–13	LS
en-wikipedia-org-4107	387	2	.	.	.
en-wikipedia-org-4107	388	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	388	2	30	30	CD
en-wikipedia-org-4107	388	3	December	December	NNP
en-wikipedia-org-4107	388	4	2013	2013	CD
en-wikipedia-org-4107	388	5	.	.	.
en-wikipedia-org-4107	389	1	^	^	NNP
en-wikipedia-org-4107	389	2	a	a	DT
en-wikipedia-org-4107	389	3	b	b	NN
en-wikipedia-org-4107	389	4	c	c	NN
en-wikipedia-org-4107	389	5	d	d	NN
en-wikipedia-org-4107	389	6	Santagati	Santagati	NNP
en-wikipedia-org-4107	389	7	NA	NA	NNP
en-wikipedia-org-4107	389	8	,	,	,
en-wikipedia-org-4107	389	9	Ferrara	Ferrara	NNP
en-wikipedia-org-4107	389	10	G	G	NNP
en-wikipedia-org-4107	389	11	,	,	,
en-wikipedia-org-4107	389	12	Marrazzo	Marrazzo	NNP
en-wikipedia-org-4107	389	13	A	A	NNP
en-wikipedia-org-4107	389	14	,	,	,
en-wikipedia-org-4107	389	15	Ronsisvalle	Ronsisvalle	NNP
en-wikipedia-org-4107	389	16	G	G	NNP
en-wikipedia-org-4107	389	17	(	(	-LRB-
en-wikipedia-org-4107	389	18	September	September	NNP
en-wikipedia-org-4107	389	19	2002	2002	CD
en-wikipedia-org-4107	389	20	)	)	-RRB-
en-wikipedia-org-4107	389	21	.	.	.
en-wikipedia-org-4107	390	1	"	"	``
en-wikipedia-org-4107	390	2	Simultaneous	simultaneous	JJ
en-wikipedia-org-4107	390	3	determination	determination	NN
en-wikipedia-org-4107	390	4	of	of	IN
en-wikipedia-org-4107	390	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	390	6	and	and	CC
en-wikipedia-org-4107	390	7	one	one	CD
en-wikipedia-org-4107	390	8	of	of	IN
en-wikipedia-org-4107	390	9	its	-PRON-	PRP$
en-wikipedia-org-4107	390	10	metabolites	metabolite	NNS
en-wikipedia-org-4107	390	11	by	by	IN
en-wikipedia-org-4107	390	12	HPLC	hplc	NN
en-wikipedia-org-4107	390	13	with	with	IN
en-wikipedia-org-4107	390	14	electrochemical	electrochemical	JJ
en-wikipedia-org-4107	390	15	detection	detection	NN
en-wikipedia-org-4107	390	16	"	"	''
en-wikipedia-org-4107	390	17	.	.	.
en-wikipedia-org-4107	391	1	Journal	Journal	NNP
en-wikipedia-org-4107	391	2	of	of	IN
en-wikipedia-org-4107	391	3	Pharmaceutical	Pharmaceutical	NNP
en-wikipedia-org-4107	391	4	and	and	CC
en-wikipedia-org-4107	391	5	Biomedical	Biomedical	NNP
en-wikipedia-org-4107	391	6	Analysis	Analysis	NNP
en-wikipedia-org-4107	391	7	.	.	.
en-wikipedia-org-4107	392	1	30	30	CD
en-wikipedia-org-4107	392	2	(	(	-LRB-
en-wikipedia-org-4107	392	3	2	2	CD
en-wikipedia-org-4107	392	4	)	)	-RRB-
en-wikipedia-org-4107	392	5	:	:	:
en-wikipedia-org-4107	392	6	247–255	247–255	CD
en-wikipedia-org-4107	392	7	.	.	.
en-wikipedia-org-4107	393	1	doi:10.1016	doi:10.1016	JJ
en-wikipedia-org-4107	393	2	/	/	SYM
en-wikipedia-org-4107	393	3	S0731	S0731	NNP
en-wikipedia-org-4107	393	4	-	-	HYPH
en-wikipedia-org-4107	393	5	7085(02)00330	7085(02)00330	NNP
en-wikipedia-org-4107	393	6	-	-	HYPH
en-wikipedia-org-4107	393	7	8	8	CD
en-wikipedia-org-4107	393	8	.	.	.
en-wikipedia-org-4107	394	1	PMID	PMID	NNP
en-wikipedia-org-4107	394	2	 	  	_SP
en-wikipedia-org-4107	394	3	12191709	12191709	CD
en-wikipedia-org-4107	394	4	.	.	.
en-wikipedia-org-4107	395	1	^	^	FW
en-wikipedia-org-4107	395	2	"	"	``
en-wikipedia-org-4107	395	3	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	395	4	"	"	''
en-wikipedia-org-4107	395	5	.	.	.
en-wikipedia-org-4107	396	1	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	396	2	/	/	SYM
en-wikipedia-org-4107	396	3	dextroamphetamine	dextroamphetamine	NNP
en-wikipedia-org-4107	396	4	.	.	.
en-wikipedia-org-4107	397	1	Medscape	Medscape	NNP
en-wikipedia-org-4107	397	2	.	.	.
en-wikipedia-org-4107	398	1	WebMD	WebMD	NNP
en-wikipedia-org-4107	398	2	.	.	.
en-wikipedia-org-4107	399	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	399	2	21	21	CD
en-wikipedia-org-4107	399	3	January	January	NNP
en-wikipedia-org-4107	399	4	2016	2016	CD
en-wikipedia-org-4107	399	5	.	.	.
en-wikipedia-org-4107	400	1	Onset	onset	NN
en-wikipedia-org-4107	400	2	of	of	IN
en-wikipedia-org-4107	400	3	action	action	NN
en-wikipedia-org-4107	400	4	:	:	:
en-wikipedia-org-4107	400	5	30–60	30–60	NNP
en-wikipedia-org-4107	400	6	min	min	NNP
en-wikipedia-org-4107	400	7	^	^	NNP
en-wikipedia-org-4107	400	8	a	a	DT
en-wikipedia-org-4107	400	9	b	b	NN
en-wikipedia-org-4107	400	10	c	c	NN
en-wikipedia-org-4107	400	11	Millichap	Millichap	NNP
en-wikipedia-org-4107	400	12	JG	JG	NNP
en-wikipedia-org-4107	400	13	(	(	-LRB-
en-wikipedia-org-4107	400	14	2010	2010	CD
en-wikipedia-org-4107	400	15	)	)	-RRB-
en-wikipedia-org-4107	400	16	.	.	.
en-wikipedia-org-4107	401	1	"	"	``
en-wikipedia-org-4107	401	2	Chapter	chapter	NN
en-wikipedia-org-4107	401	3	9	9	CD
en-wikipedia-org-4107	401	4	:	:	:
en-wikipedia-org-4107	401	5	Medications	medication	NNS
en-wikipedia-org-4107	401	6	for	for	IN
en-wikipedia-org-4107	401	7	ADHD	ADHD	NNP
en-wikipedia-org-4107	401	8	"	"	''
en-wikipedia-org-4107	401	9	.	.	.
en-wikipedia-org-4107	402	1	In	in	IN
en-wikipedia-org-4107	402	2	Millichap	Millichap	NNP
en-wikipedia-org-4107	402	3	JG	JG	NNP
en-wikipedia-org-4107	402	4	(	(	-LRB-
en-wikipedia-org-4107	402	5	ed	ed	NNP
en-wikipedia-org-4107	402	6	.	.	.
en-wikipedia-org-4107	402	7	)	)	-RRB-
en-wikipedia-org-4107	402	8	.	.	.
en-wikipedia-org-4107	403	1	Attention	attention	NN
en-wikipedia-org-4107	403	2	Deficit	Deficit	NNP
en-wikipedia-org-4107	403	3	Hyperactivity	Hyperactivity	NNP
en-wikipedia-org-4107	403	4	Disorder	Disorder	NNP
en-wikipedia-org-4107	403	5	Handbook	Handbook	NNP
en-wikipedia-org-4107	403	6	:	:	:
en-wikipedia-org-4107	403	7	A	a	DT
en-wikipedia-org-4107	403	8	Physician	Physician	NNP
en-wikipedia-org-4107	403	9	's	's	POS
en-wikipedia-org-4107	403	10	Guide	Guide	NNP
en-wikipedia-org-4107	403	11	to	to	IN
en-wikipedia-org-4107	403	12	ADHD	ADHD	NNP
en-wikipedia-org-4107	403	13	(	(	-LRB-
en-wikipedia-org-4107	403	14	2nd	2nd	NNP
en-wikipedia-org-4107	403	15	ed	ed	NNP
en-wikipedia-org-4107	403	16	.	.	.
en-wikipedia-org-4107	403	17	)	)	-RRB-
en-wikipedia-org-4107	403	18	.	.	.
en-wikipedia-org-4107	404	1	New	New	NNP
en-wikipedia-org-4107	404	2	York	York	NNP
en-wikipedia-org-4107	404	3	,	,	,
en-wikipedia-org-4107	404	4	USA	USA	NNP
en-wikipedia-org-4107	404	5	:	:	:
en-wikipedia-org-4107	404	6	Springer	Springer	NNP
en-wikipedia-org-4107	404	7	.	.	.
en-wikipedia-org-4107	405	1	p.	p.	NN
en-wikipedia-org-4107	405	2	 	  	_SP
en-wikipedia-org-4107	405	3	112	112	CD
en-wikipedia-org-4107	405	4	.	.	.
en-wikipedia-org-4107	406	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	406	2	 	  	_SP
en-wikipedia-org-4107	406	3	9781441913968	9781441913968	CD
en-wikipedia-org-4107	406	4	.	.	.
en-wikipedia-org-4107	407	1	Table	table	NN
en-wikipedia-org-4107	407	2	9.2	9.2	CD
en-wikipedia-org-4107	407	3	Dextroamphetamine	dextroamphetamine	JJ
en-wikipedia-org-4107	407	4	formulations	formulation	NNS
en-wikipedia-org-4107	407	5	of	of	IN
en-wikipedia-org-4107	407	6	stimulant	stimulant	NN
en-wikipedia-org-4107	407	7	medication	medication	NN
en-wikipedia-org-4107	407	8	Dexedrine	Dexedrine	NNP
en-wikipedia-org-4107	407	9	[	[	-LRB-
en-wikipedia-org-4107	407	10	Peak:2–3	peak:2–3	NN
en-wikipedia-org-4107	407	11	 	  	_SP
en-wikipedia-org-4107	407	12	h	h	NN
en-wikipedia-org-4107	407	13	]	]	-RRB-
en-wikipedia-org-4107	407	14	[	[	-LRB-
en-wikipedia-org-4107	407	15	Duration:5–6	Duration:5–6	,
en-wikipedia-org-4107	407	16	 	  	_SP
en-wikipedia-org-4107	407	17	h	h	NN
en-wikipedia-org-4107	407	18	]	]	-RRB-
en-wikipedia-org-4107	407	19	 	  	_SP
en-wikipedia-org-4107	407	20	...	...	:
en-wikipedia-org-4107	407	21	Adderall	Adderall	NNP
en-wikipedia-org-4107	407	22	[	[	-LRB-
en-wikipedia-org-4107	407	23	Peak:2–3	peak:2–3	NN
en-wikipedia-org-4107	407	24	 	  	_SP
en-wikipedia-org-4107	407	25	h	h	NN
en-wikipedia-org-4107	407	26	]	]	-RRB-
en-wikipedia-org-4107	407	27	[	[	-LRB-
en-wikipedia-org-4107	407	28	Duration:5–7	Duration:5–7	,
en-wikipedia-org-4107	407	29	 	  	_SP
en-wikipedia-org-4107	407	30	h	h	LS
en-wikipedia-org-4107	407	31	]	]	-RRB-
en-wikipedia-org-4107	407	32	Dexedrine	dexedrine	NN
en-wikipedia-org-4107	407	33	spansules	spansule	NNS
en-wikipedia-org-4107	407	34	[	[	-LRB-
en-wikipedia-org-4107	407	35	Peak:7–8	peak:7–8	CC
en-wikipedia-org-4107	407	36	 	  	_SP
en-wikipedia-org-4107	407	37	h	h	LS
en-wikipedia-org-4107	407	38	]	]	-RRB-
en-wikipedia-org-4107	407	39	[	[	-LRB-
en-wikipedia-org-4107	407	40	Duration:12	Duration:12	NNP
en-wikipedia-org-4107	407	41	 	  	_SP
en-wikipedia-org-4107	407	42	h	h	NNP
en-wikipedia-org-4107	407	43	]	]	-RRB-
en-wikipedia-org-4107	407	44	 	  	_SP
en-wikipedia-org-4107	407	45	...	...	:
en-wikipedia-org-4107	407	46	Adderall	Adderall	NNP
en-wikipedia-org-4107	407	47	XR	XR	NNP
en-wikipedia-org-4107	407	48	[	[	-LRB-
en-wikipedia-org-4107	407	49	Peak:7–8	peak:7–8	IN
en-wikipedia-org-4107	407	50	 	  	_SP
en-wikipedia-org-4107	407	51	h	h	LS
en-wikipedia-org-4107	407	52	]	]	-RRB-
en-wikipedia-org-4107	407	53	[	[	-LRB-
en-wikipedia-org-4107	407	54	Duration:12	Duration:12	NNP
en-wikipedia-org-4107	407	55	 	  	_SP
en-wikipedia-org-4107	407	56	h	h	NN
en-wikipedia-org-4107	407	57	]	]	-RRB-
en-wikipedia-org-4107	407	58	Vyvanse	Vyvanse	NNP
en-wikipedia-org-4107	407	59	[	[	-LRB-
en-wikipedia-org-4107	407	60	Peak:3–4	peak:3–4	IN
en-wikipedia-org-4107	407	61	 	  	_SP
en-wikipedia-org-4107	407	62	h	h	NNP
en-wikipedia-org-4107	407	63	]	]	-RRB-
en-wikipedia-org-4107	407	64	[	[	-LRB-
en-wikipedia-org-4107	407	65	Duration:12	Duration:12	NNP
en-wikipedia-org-4107	407	66	 	  	_SP
en-wikipedia-org-4107	407	67	h	h	NN
en-wikipedia-org-4107	407	68	]	]	-RRB-
en-wikipedia-org-4107	407	69	^	^	.
en-wikipedia-org-4107	407	70	Brams	Brams	NNP
en-wikipedia-org-4107	407	71	M	M	NNP
en-wikipedia-org-4107	407	72	,	,	,
en-wikipedia-org-4107	407	73	Mao	Mao	NNP
en-wikipedia-org-4107	407	74	AR	AR	NNP
en-wikipedia-org-4107	407	75	,	,	,
en-wikipedia-org-4107	407	76	Doyle	Doyle	NNP
en-wikipedia-org-4107	407	77	RL	RL	NNP
en-wikipedia-org-4107	407	78	(	(	-LRB-
en-wikipedia-org-4107	407	79	September	September	NNP
en-wikipedia-org-4107	407	80	2008	2008	CD
en-wikipedia-org-4107	407	81	)	)	-RRB-
en-wikipedia-org-4107	407	82	.	.	.
en-wikipedia-org-4107	408	1	"	"	``
en-wikipedia-org-4107	408	2	Onset	onset	NN
en-wikipedia-org-4107	408	3	of	of	IN
en-wikipedia-org-4107	408	4	efficacy	efficacy	NN
en-wikipedia-org-4107	408	5	of	of	IN
en-wikipedia-org-4107	408	6	long	long	RB
en-wikipedia-org-4107	408	7	-	-	HYPH
en-wikipedia-org-4107	408	8	acting	act	VBG
en-wikipedia-org-4107	408	9	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	408	10	in	in	IN
en-wikipedia-org-4107	408	11	pediatric	pediatric	JJ
en-wikipedia-org-4107	408	12	attention	attention	NN
en-wikipedia-org-4107	408	13	-	-	HYPH
en-wikipedia-org-4107	408	14	deficit	deficit	NN
en-wikipedia-org-4107	408	15	/	/	SYM
en-wikipedia-org-4107	408	16	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	408	17	disorder	disorder	NN
en-wikipedia-org-4107	408	18	"	"	''
en-wikipedia-org-4107	408	19	.	.	.
en-wikipedia-org-4107	409	1	Postgraduate	Postgraduate	NNP
en-wikipedia-org-4107	409	2	Medicine	Medicine	NNP
en-wikipedia-org-4107	409	3	.	.	.
en-wikipedia-org-4107	410	1	120	120	CD
en-wikipedia-org-4107	410	2	(	(	-LRB-
en-wikipedia-org-4107	410	3	3	3	CD
en-wikipedia-org-4107	410	4	)	)	-RRB-
en-wikipedia-org-4107	410	5	:	:	:
en-wikipedia-org-4107	410	6	69–88	69–88	LS
en-wikipedia-org-4107	410	7	.	.	.
en-wikipedia-org-4107	411	1	doi:10.3810	doi:10.3810	NNP
en-wikipedia-org-4107	411	2	/	/	SYM
en-wikipedia-org-4107	411	3	pgm.2008.09.1909	pgm.2008.09.1909	NNP
en-wikipedia-org-4107	411	4	.	.	.
en-wikipedia-org-4107	412	1	PMID	PMID	NNP
en-wikipedia-org-4107	412	2	 	  	_SP
en-wikipedia-org-4107	412	3	18824827	18824827	CD
en-wikipedia-org-4107	412	4	.	.	.
en-wikipedia-org-4107	413	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	413	2	 	  	_SP
en-wikipedia-org-4107	413	3	31791162	31791162	CD
en-wikipedia-org-4107	413	4	.	.	.
en-wikipedia-org-4107	414	1	^	^	NNP
en-wikipedia-org-4107	414	2	a	a	DT
en-wikipedia-org-4107	414	3	b	b	NN
en-wikipedia-org-4107	414	4	c	c	NN
en-wikipedia-org-4107	414	5	d	d	NN
en-wikipedia-org-4107	414	6	"	"	``
en-wikipedia-org-4107	414	7	Adderall-	Adderall-	NNP
en-wikipedia-org-4107	414	8	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	414	9	saccharate	saccharate	NN
en-wikipedia-org-4107	414	10	,	,	,
en-wikipedia-org-4107	414	11	amphetamine	amphetamine	NN
en-wikipedia-org-4107	414	12	aspartate	aspartate	NN
en-wikipedia-org-4107	414	13	,	,	,
en-wikipedia-org-4107	414	14	dextroamphetamine	dextroamphetamine	JJ
en-wikipedia-org-4107	414	15	sulfate	sulfate	NN
en-wikipedia-org-4107	414	16	,	,	,
en-wikipedia-org-4107	414	17	and	and	CC
en-wikipedia-org-4107	414	18	amphetamine	amphetamine	VB
en-wikipedia-org-4107	414	19	sulfate	sulfate	NN
en-wikipedia-org-4107	414	20	tablet	tablet	NN
en-wikipedia-org-4107	414	21	"	"	''
en-wikipedia-org-4107	414	22	.	.	.
en-wikipedia-org-4107	415	1	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	415	2	.	.	.
en-wikipedia-org-4107	416	1	Teva	Teva	NNP
en-wikipedia-org-4107	416	2	Pharmaceuticals	Pharmaceuticals	NNP
en-wikipedia-org-4107	416	3	USA	USA	NNP
en-wikipedia-org-4107	416	4	,	,	,
en-wikipedia-org-4107	416	5	Inc.	Inc.	NNP
en-wikipedia-org-4107	416	6	8	8	CD
en-wikipedia-org-4107	416	7	November	November	NNP
en-wikipedia-org-4107	416	8	2019	2019	CD
en-wikipedia-org-4107	416	9	.	.	.
en-wikipedia-org-4107	417	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	417	2	22	22	CD
en-wikipedia-org-4107	417	3	December	December	NNP
en-wikipedia-org-4107	417	4	2019	2019	CD
en-wikipedia-org-4107	417	5	.	.	.
en-wikipedia-org-4107	418	1	^	^	NNP
en-wikipedia-org-4107	418	2	a	a	DT
en-wikipedia-org-4107	418	3	b	b	NNP
en-wikipedia-org-4107	418	4	c	c	NNP
en-wikipedia-org-4107	418	5	d	d	NNP
en-wikipedia-org-4107	418	6	e	e	NNP
en-wikipedia-org-4107	418	7	f	f	NNP
en-wikipedia-org-4107	418	8	"	"	``
en-wikipedia-org-4107	418	9	Metabolism	Metabolism	NNP
en-wikipedia-org-4107	418	10	/	/	SYM
en-wikipedia-org-4107	418	11	Pharmacokinetics	Pharmacokinetics	NNP
en-wikipedia-org-4107	418	12	"	"	''
en-wikipedia-org-4107	418	13	.	.	.
en-wikipedia-org-4107	419	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	419	2	.	.	.
en-wikipedia-org-4107	420	1	United	United	NNP
en-wikipedia-org-4107	420	2	States	States	NNP
en-wikipedia-org-4107	420	3	National	National	NNP
en-wikipedia-org-4107	420	4	Library	Library	NNP
en-wikipedia-org-4107	420	5	of	of	IN
en-wikipedia-org-4107	420	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	420	7	 	  	_SP
en-wikipedia-org-4107	420	8	–	–	:
en-wikipedia-org-4107	420	9	Toxicology	Toxicology	NNP
en-wikipedia-org-4107	420	10	Data	Data	NNP
en-wikipedia-org-4107	420	11	Network	Network	NNP
en-wikipedia-org-4107	420	12	.	.	.
en-wikipedia-org-4107	421	1	Hazardous	Hazardous	NNP
en-wikipedia-org-4107	421	2	Substances	Substances	NNP
en-wikipedia-org-4107	421	3	Data	Data	NNP
en-wikipedia-org-4107	421	4	Bank	Bank	NNP
en-wikipedia-org-4107	421	5	.	.	.
en-wikipedia-org-4107	422	1	Archived	archived	JJ
en-wikipedia-org-4107	422	2	from	from	IN
en-wikipedia-org-4107	422	3	the	the	DT
en-wikipedia-org-4107	422	4	original	original	NN
en-wikipedia-org-4107	422	5	on	on	IN
en-wikipedia-org-4107	422	6	2	2	CD
en-wikipedia-org-4107	422	7	October	October	NNP
en-wikipedia-org-4107	422	8	2017	2017	CD
en-wikipedia-org-4107	422	9	.	.	.
en-wikipedia-org-4107	423	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	423	2	2	2	CD
en-wikipedia-org-4107	423	3	October	October	NNP
en-wikipedia-org-4107	423	4	2017	2017	CD
en-wikipedia-org-4107	423	5	.	.	.
en-wikipedia-org-4107	424	1	Duration	duration	NN
en-wikipedia-org-4107	424	2	of	of	IN
en-wikipedia-org-4107	424	3	effect	effect	NN
en-wikipedia-org-4107	424	4	varies	vary	VBZ
en-wikipedia-org-4107	424	5	depending	depend	VBG
en-wikipedia-org-4107	424	6	on	on	IN
en-wikipedia-org-4107	424	7	agent	agent	NN
en-wikipedia-org-4107	424	8	and	and	CC
en-wikipedia-org-4107	424	9	urine	urine	NN
en-wikipedia-org-4107	424	10	pH.	pH.	NNP
en-wikipedia-org-4107	425	1	Excretion	excretion	NN
en-wikipedia-org-4107	425	2	is	be	VBZ
en-wikipedia-org-4107	425	3	enhanced	enhance	VBN
en-wikipedia-org-4107	425	4	in	in	IN
en-wikipedia-org-4107	425	5	more	more	RBR
en-wikipedia-org-4107	425	6	acidic	acidic	JJ
en-wikipedia-org-4107	425	7	urine	urine	NN
en-wikipedia-org-4107	425	8	.	.	.
en-wikipedia-org-4107	426	1	Half	half	JJ
en-wikipedia-org-4107	426	2	-	-	HYPH
en-wikipedia-org-4107	426	3	life	life	NN
en-wikipedia-org-4107	426	4	is	be	VBZ
en-wikipedia-org-4107	426	5	7	7	CD
en-wikipedia-org-4107	426	6	to	to	TO
en-wikipedia-org-4107	426	7	34	34	CD
en-wikipedia-org-4107	426	8	 	  	_SP
en-wikipedia-org-4107	426	9	hours	hour	NNS
en-wikipedia-org-4107	426	10	and	and	CC
en-wikipedia-org-4107	426	11	is	be	VBZ
en-wikipedia-org-4107	426	12	,	,	,
en-wikipedia-org-4107	426	13	in	in	IN
en-wikipedia-org-4107	426	14	part	part	NN
en-wikipedia-org-4107	426	15	,	,	,
en-wikipedia-org-4107	426	16	dependent	dependent	JJ
en-wikipedia-org-4107	426	17	on	on	IN
en-wikipedia-org-4107	426	18	urine	urine	NN
en-wikipedia-org-4107	426	19	pH	pH	NNP
en-wikipedia-org-4107	426	20	(	(	-LRB-
en-wikipedia-org-4107	426	21	half	half	JJ
en-wikipedia-org-4107	426	22	-	-	HYPH
en-wikipedia-org-4107	426	23	life	life	NN
en-wikipedia-org-4107	426	24	is	be	VBZ
en-wikipedia-org-4107	426	25	longer	long	JJR
en-wikipedia-org-4107	426	26	with	with	IN
en-wikipedia-org-4107	426	27	alkaline	alkaline	NN
en-wikipedia-org-4107	426	28	urine	urine	NN
en-wikipedia-org-4107	426	29	)	)	-RRB-
en-wikipedia-org-4107	426	30	.	.	.
en-wikipedia-org-4107	427	1	...	...	NFP
en-wikipedia-org-4107	427	2	Amphetamines	amphetamine	NNS
en-wikipedia-org-4107	427	3	are	be	VBP
en-wikipedia-org-4107	427	4	distributed	distribute	VBN
en-wikipedia-org-4107	427	5	into	into	IN
en-wikipedia-org-4107	427	6	most	most	JJS
en-wikipedia-org-4107	427	7	body	body	NN
en-wikipedia-org-4107	427	8	tissues	tissue	NNS
en-wikipedia-org-4107	427	9	with	with	IN
en-wikipedia-org-4107	427	10	high	high	JJ
en-wikipedia-org-4107	427	11	concentrations	concentration	NNS
en-wikipedia-org-4107	427	12	occurring	occur	VBG
en-wikipedia-org-4107	427	13	in	in	IN
en-wikipedia-org-4107	427	14	the	the	DT
en-wikipedia-org-4107	427	15	brain	brain	NN
en-wikipedia-org-4107	427	16	and	and	CC
en-wikipedia-org-4107	427	17	CSF	csf	NN
en-wikipedia-org-4107	427	18	.	.	.
en-wikipedia-org-4107	428	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	428	2	appears	appear	VBZ
en-wikipedia-org-4107	428	3	in	in	IN
en-wikipedia-org-4107	428	4	the	the	DT
en-wikipedia-org-4107	428	5	urine	urine	NN
en-wikipedia-org-4107	428	6	within	within	IN
en-wikipedia-org-4107	428	7	about	about	RB
en-wikipedia-org-4107	428	8	3	3	CD
en-wikipedia-org-4107	428	9	 	  	_SP
en-wikipedia-org-4107	428	10	hours	hour	NNS
en-wikipedia-org-4107	428	11	following	follow	VBG
en-wikipedia-org-4107	428	12	oral	oral	JJ
en-wikipedia-org-4107	428	13	administration	administration	NN
en-wikipedia-org-4107	428	14	.	.	.
en-wikipedia-org-4107	429	1	...	...	:
en-wikipedia-org-4107	429	2	Three	three	CD
en-wikipedia-org-4107	429	3	days	day	NNS
en-wikipedia-org-4107	429	4	after	after	IN
en-wikipedia-org-4107	429	5	a	a	DT
en-wikipedia-org-4107	429	6	dose	dose	NN
en-wikipedia-org-4107	429	7	of	of	IN
en-wikipedia-org-4107	429	8	(	(	-LRB-
en-wikipedia-org-4107	429	9	+	+	CC
en-wikipedia-org-4107	429	10	or	or	CC
en-wikipedia-org-4107	429	11	-)-amphetamine	-)-amphetamine	:
en-wikipedia-org-4107	429	12	,	,	,
en-wikipedia-org-4107	429	13	human	human	JJ
en-wikipedia-org-4107	429	14	subjects	subject	NNS
en-wikipedia-org-4107	429	15	had	have	VBD
en-wikipedia-org-4107	429	16	excreted	excrete	VBN
en-wikipedia-org-4107	429	17	91	91	CD
en-wikipedia-org-4107	429	18	%	%	NN
en-wikipedia-org-4107	429	19	of	of	IN
en-wikipedia-org-4107	429	20	the	the	DT
en-wikipedia-org-4107	429	21	(	(	-LRB-
en-wikipedia-org-4107	429	22	14)C	14)c	CD
en-wikipedia-org-4107	429	23	in	in	IN
en-wikipedia-org-4107	429	24	the	the	DT
en-wikipedia-org-4107	429	25	urine	urine	NN
en-wikipedia-org-4107	429	26	^	^	NN
en-wikipedia-org-4107	429	27	a	a	DT
en-wikipedia-org-4107	429	28	b	b	NNP
en-wikipedia-org-4107	429	29	Mignot	Mignot	NNP
en-wikipedia-org-4107	429	30	EJ	EJ	NNP
en-wikipedia-org-4107	429	31	(	(	-LRB-
en-wikipedia-org-4107	429	32	October	October	NNP
en-wikipedia-org-4107	429	33	2012	2012	CD
en-wikipedia-org-4107	429	34	)	)	-RRB-
en-wikipedia-org-4107	429	35	.	.	.
en-wikipedia-org-4107	430	1	"	"	``
en-wikipedia-org-4107	430	2	A	a	DT
en-wikipedia-org-4107	430	3	practical	practical	JJ
en-wikipedia-org-4107	430	4	guide	guide	NN
en-wikipedia-org-4107	430	5	to	to	IN
en-wikipedia-org-4107	430	6	the	the	DT
en-wikipedia-org-4107	430	7	therapy	therapy	NN
en-wikipedia-org-4107	430	8	of	of	IN
en-wikipedia-org-4107	430	9	narcolepsy	narcolepsy	NN
en-wikipedia-org-4107	430	10	and	and	CC
en-wikipedia-org-4107	430	11	hypersomnia	hypersomnia	NNP
en-wikipedia-org-4107	430	12	syndromes	syndrome	VBZ
en-wikipedia-org-4107	430	13	"	"	''
en-wikipedia-org-4107	430	14	.	.	.
en-wikipedia-org-4107	431	1	Neurotherapeutics	neurotherapeutic	NNS
en-wikipedia-org-4107	431	2	.	.	.
en-wikipedia-org-4107	432	1	9	9	CD
en-wikipedia-org-4107	432	2	(	(	-LRB-
en-wikipedia-org-4107	432	3	4	4	CD
en-wikipedia-org-4107	432	4	)	)	-RRB-
en-wikipedia-org-4107	432	5	:	:	:
en-wikipedia-org-4107	432	6	739–752	739–752	CD
en-wikipedia-org-4107	432	7	.	.	.
en-wikipedia-org-4107	433	1	doi:10.1007	doi:10.1007	NNP
en-wikipedia-org-4107	433	2	/	/	SYM
en-wikipedia-org-4107	433	3	s13311	s13311	CD
en-wikipedia-org-4107	433	4	-	-	HYPH
en-wikipedia-org-4107	433	5	012	012	CD
en-wikipedia-org-4107	433	6	-	-	HYPH
en-wikipedia-org-4107	433	7	0150	0150	CD
en-wikipedia-org-4107	433	8	-	-	SYM
en-wikipedia-org-4107	433	9	9	9	CD
en-wikipedia-org-4107	433	10	.	.	.
en-wikipedia-org-4107	434	1	PMC	PMC	NNP
en-wikipedia-org-4107	434	2	 	  	_SP
en-wikipedia-org-4107	434	3	3480574	3480574	CD
en-wikipedia-org-4107	434	4	.	.	.
en-wikipedia-org-4107	435	1	PMID	PMID	NNP
en-wikipedia-org-4107	435	2	 	  	_SP
en-wikipedia-org-4107	435	3	23065655	23065655	CD
en-wikipedia-org-4107	435	4	.	.	.
en-wikipedia-org-4107	436	1	^	^	NNP
en-wikipedia-org-4107	436	2	a	a	DT
en-wikipedia-org-4107	436	3	b	b	NNP
en-wikipedia-org-4107	436	4	c	c	NNP
en-wikipedia-org-4107	436	5	d	d	NNP
en-wikipedia-org-4107	436	6	e	e	NNP
en-wikipedia-org-4107	436	7	f	f	NNP
en-wikipedia-org-4107	436	8	g	g	NNP
en-wikipedia-org-4107	436	9	h	h	NNP
en-wikipedia-org-4107	436	10	i	i	PRP
en-wikipedia-org-4107	436	11	Glennon	Glennon	NNP
en-wikipedia-org-4107	436	12	RA	RA	NNP
en-wikipedia-org-4107	436	13	(	(	-LRB-
en-wikipedia-org-4107	436	14	2013	2013	CD
en-wikipedia-org-4107	436	15	)	)	-RRB-
en-wikipedia-org-4107	436	16	.	.	.
en-wikipedia-org-4107	437	1	"	"	``
en-wikipedia-org-4107	437	2	Phenylisopropylamine	Phenylisopropylamine	NNP
en-wikipedia-org-4107	437	3	stimulants	stimulant	NNS
en-wikipedia-org-4107	437	4	:	:	:
en-wikipedia-org-4107	437	5	amphetamine	amphetamine	VB
en-wikipedia-org-4107	437	6	-	-	HYPH
en-wikipedia-org-4107	437	7	related	relate	VBN
en-wikipedia-org-4107	437	8	agents	agent	NNS
en-wikipedia-org-4107	437	9	"	"	''
en-wikipedia-org-4107	437	10	.	.	.
en-wikipedia-org-4107	438	1	In	in	IN
en-wikipedia-org-4107	438	2	Lemke	Lemke	NNP
en-wikipedia-org-4107	438	3	TL	TL	NNP
en-wikipedia-org-4107	438	4	,	,	,
en-wikipedia-org-4107	438	5	Williams	Williams	NNP
en-wikipedia-org-4107	438	6	DA	DA	NNP
en-wikipedia-org-4107	438	7	,	,	,
en-wikipedia-org-4107	438	8	Roche	Roche	NNP
en-wikipedia-org-4107	438	9	VF	VF	NNP
en-wikipedia-org-4107	438	10	,	,	,
en-wikipedia-org-4107	438	11	Zito	Zito	NNP
en-wikipedia-org-4107	438	12	W	W	NNP
en-wikipedia-org-4107	438	13	(	(	-LRB-
en-wikipedia-org-4107	438	14	eds	eds	NNP
en-wikipedia-org-4107	438	15	.	.	.
en-wikipedia-org-4107	438	16	)	)	-RRB-
en-wikipedia-org-4107	438	17	.	.	.
en-wikipedia-org-4107	439	1	Foye	Foye	NNP
en-wikipedia-org-4107	439	2	's	's	POS
en-wikipedia-org-4107	439	3	principles	principle	NNS
en-wikipedia-org-4107	439	4	of	of	IN
en-wikipedia-org-4107	439	5	medicinal	medicinal	JJ
en-wikipedia-org-4107	439	6	chemistry	chemistry	NN
en-wikipedia-org-4107	439	7	(	(	-LRB-
en-wikipedia-org-4107	439	8	7th	7th	NNP
en-wikipedia-org-4107	439	9	ed	ed	NNP
en-wikipedia-org-4107	439	10	.	.	.
en-wikipedia-org-4107	439	11	)	)	-RRB-
en-wikipedia-org-4107	439	12	.	.	.
en-wikipedia-org-4107	440	1	Philadelphia	Philadelphia	NNP
en-wikipedia-org-4107	440	2	,	,	,
en-wikipedia-org-4107	440	3	USA	USA	NNP
en-wikipedia-org-4107	440	4	:	:	:
en-wikipedia-org-4107	440	5	Wolters	Wolters	NNP
en-wikipedia-org-4107	440	6	Kluwer	Kluwer	NNP
en-wikipedia-org-4107	440	7	Health	Health	NNP
en-wikipedia-org-4107	440	8	/	/	SYM
en-wikipedia-org-4107	440	9	Lippincott	Lippincott	NNP
en-wikipedia-org-4107	440	10	Williams	Williams	NNP
en-wikipedia-org-4107	440	11	&	&	CC
en-wikipedia-org-4107	440	12	Wilkins	Wilkins	NNP
en-wikipedia-org-4107	440	13	.	.	.
en-wikipedia-org-4107	441	1	pp	pp	NNP
en-wikipedia-org-4107	441	2	.	.	.
en-wikipedia-org-4107	442	1	646–648	646–648	CD
en-wikipedia-org-4107	442	2	.	.	.
en-wikipedia-org-4107	443	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	443	2	 	  	_SP
en-wikipedia-org-4107	443	3	9781609133450	9781609133450	CD
en-wikipedia-org-4107	443	4	.	.	.
en-wikipedia-org-4107	444	1	The	the	DT
en-wikipedia-org-4107	444	2	simplest	simple	JJS
en-wikipedia-org-4107	444	3	unsubstituted	unsubstituted	JJ
en-wikipedia-org-4107	444	4	phenylisopropylamine	phenylisopropylamine	NN
en-wikipedia-org-4107	444	5	,	,	,
en-wikipedia-org-4107	444	6	1-phenyl-2-aminopropane	1-phenyl-2-aminopropane	CD
en-wikipedia-org-4107	444	7	,	,	,
en-wikipedia-org-4107	444	8	or	or	CC
en-wikipedia-org-4107	444	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	444	10	,	,	,
en-wikipedia-org-4107	444	11	serves	serve	VBZ
en-wikipedia-org-4107	444	12	as	as	IN
en-wikipedia-org-4107	444	13	a	a	DT
en-wikipedia-org-4107	444	14	common	common	JJ
en-wikipedia-org-4107	444	15	structural	structural	JJ
en-wikipedia-org-4107	444	16	template	template	NN
en-wikipedia-org-4107	444	17	for	for	IN
en-wikipedia-org-4107	444	18	hallucinogens	hallucinogen	NNS
en-wikipedia-org-4107	444	19	and	and	CC
en-wikipedia-org-4107	444	20	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	444	21	.	.	.
en-wikipedia-org-4107	445	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	445	2	produces	produce	VBZ
en-wikipedia-org-4107	445	3	central	central	JJ
en-wikipedia-org-4107	445	4	stimulant	stimulant	NN
en-wikipedia-org-4107	445	5	,	,	,
en-wikipedia-org-4107	445	6	anorectic	anorectic	JJ
en-wikipedia-org-4107	445	7	,	,	,
en-wikipedia-org-4107	445	8	and	and	CC
en-wikipedia-org-4107	445	9	sympathomimetic	sympathomimetic	JJ
en-wikipedia-org-4107	445	10	actions	action	NNS
en-wikipedia-org-4107	445	11	,	,	,
en-wikipedia-org-4107	445	12	and	and	CC
en-wikipedia-org-4107	445	13	it	-PRON-	PRP
en-wikipedia-org-4107	445	14	is	be	VBZ
en-wikipedia-org-4107	445	15	the	the	DT
en-wikipedia-org-4107	445	16	prototype	prototype	NN
en-wikipedia-org-4107	445	17	member	member	NN
en-wikipedia-org-4107	445	18	of	of	IN
en-wikipedia-org-4107	445	19	this	this	DT
en-wikipedia-org-4107	445	20	class	class	NN
en-wikipedia-org-4107	445	21	(	(	-LRB-
en-wikipedia-org-4107	445	22	39	39	CD
en-wikipedia-org-4107	445	23	)	)	-RRB-
en-wikipedia-org-4107	445	24	.	.	.
en-wikipedia-org-4107	446	1	...	...	NFP
en-wikipedia-org-4107	447	1	The	the	DT
en-wikipedia-org-4107	447	2	phase	phase	NN
en-wikipedia-org-4107	447	3	1	1	CD
en-wikipedia-org-4107	447	4	metabolism	metabolism	NN
en-wikipedia-org-4107	447	5	of	of	IN
en-wikipedia-org-4107	447	6	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	447	7	analogs	analogs	NNP
en-wikipedia-org-4107	447	8	is	be	VBZ
en-wikipedia-org-4107	447	9	catalyzed	catalyze	VBN
en-wikipedia-org-4107	447	10	by	by	IN
en-wikipedia-org-4107	447	11	two	two	CD
en-wikipedia-org-4107	447	12	systems	system	NNS
en-wikipedia-org-4107	447	13	:	:	:
en-wikipedia-org-4107	447	14	cytochrome	cytochrome	JJ
en-wikipedia-org-4107	447	15	P450	p450	NN
en-wikipedia-org-4107	447	16	and	and	CC
en-wikipedia-org-4107	447	17	flavin	flavin	IN
en-wikipedia-org-4107	447	18	monooxygenase	monooxygenase	NN
en-wikipedia-org-4107	447	19	.	.	.
en-wikipedia-org-4107	448	1	...	...	NFP
en-wikipedia-org-4107	448	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	448	3	can	can	MD
en-wikipedia-org-4107	448	4	also	also	RB
en-wikipedia-org-4107	448	5	undergo	undergo	VB
en-wikipedia-org-4107	448	6	aromatic	aromatic	JJ
en-wikipedia-org-4107	448	7	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	448	8	to	to	IN
en-wikipedia-org-4107	448	9	p	p	NN
en-wikipedia-org-4107	448	10	-	-	HYPH
en-wikipedia-org-4107	448	11	hydroxyamphetamine	hydroxyamphetamine	NN
en-wikipedia-org-4107	448	12	.	.	.
en-wikipedia-org-4107	449	1	...	...	NFP
en-wikipedia-org-4107	450	1	Subsequent	subsequent	JJ
en-wikipedia-org-4107	450	2	oxidation	oxidation	NN
en-wikipedia-org-4107	450	3	at	at	IN
en-wikipedia-org-4107	450	4	the	the	DT
en-wikipedia-org-4107	450	5	benzylic	benzylic	JJ
en-wikipedia-org-4107	450	6	position	position	NN
en-wikipedia-org-4107	450	7	by	by	IN
en-wikipedia-org-4107	450	8	DA	DA	NNP
en-wikipedia-org-4107	450	9	β	β	NNP
en-wikipedia-org-4107	450	10	-	-	HYPH
en-wikipedia-org-4107	450	11	hydroxylase	hydroxylase	NNP
en-wikipedia-org-4107	450	12	affords	afford	VBZ
en-wikipedia-org-4107	450	13	p	p	NN
en-wikipedia-org-4107	450	14	-	-	HYPH
en-wikipedia-org-4107	450	15	hydroxynorephedrine	hydroxynorephedrine	NN
en-wikipedia-org-4107	450	16	.	.	.
en-wikipedia-org-4107	451	1	Alternatively	alternatively	RB
en-wikipedia-org-4107	451	2	,	,	,
en-wikipedia-org-4107	451	3	direct	direct	JJ
en-wikipedia-org-4107	451	4	oxidation	oxidation	NN
en-wikipedia-org-4107	451	5	of	of	IN
en-wikipedia-org-4107	451	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	451	7	by	by	IN
en-wikipedia-org-4107	451	8	DA	DA	NNP
en-wikipedia-org-4107	451	9	β	β	NNP
en-wikipedia-org-4107	451	10	-	-	HYPH
en-wikipedia-org-4107	451	11	hydroxylase	hydroxylase	NNP
en-wikipedia-org-4107	451	12	can	can	MD
en-wikipedia-org-4107	451	13	afford	afford	VB
en-wikipedia-org-4107	451	14	norephedrine	norephedrine	NN
en-wikipedia-org-4107	451	15	.	.	.
en-wikipedia-org-4107	452	1	^	^	NNP
en-wikipedia-org-4107	452	2	a	a	DT
en-wikipedia-org-4107	452	3	b	b	NNP
en-wikipedia-org-4107	452	4	Taylor	Taylor	NNP
en-wikipedia-org-4107	452	5	KB	KB	NNP
en-wikipedia-org-4107	452	6	(	(	-LRB-
en-wikipedia-org-4107	452	7	January	January	NNP
en-wikipedia-org-4107	452	8	1974	1974	CD
en-wikipedia-org-4107	452	9	)	)	-RRB-
en-wikipedia-org-4107	452	10	.	.	.
en-wikipedia-org-4107	453	1	"	"	``
en-wikipedia-org-4107	453	2	Dopamine	dopamine	NN
en-wikipedia-org-4107	453	3	-	-	HYPH
en-wikipedia-org-4107	453	4	beta	beta	NN
en-wikipedia-org-4107	453	5	-	-	HYPH
en-wikipedia-org-4107	453	6	hydroxylase	hydroxylase	NN
en-wikipedia-org-4107	453	7	.	.	.
en-wikipedia-org-4107	454	1	Stereochemical	stereochemical	JJ
en-wikipedia-org-4107	454	2	course	course	NN
en-wikipedia-org-4107	454	3	of	of	IN
en-wikipedia-org-4107	454	4	the	the	DT
en-wikipedia-org-4107	454	5	reaction	reaction	NN
en-wikipedia-org-4107	454	6	"	"	''
en-wikipedia-org-4107	454	7	(	(	-LRB-
en-wikipedia-org-4107	454	8	PDF	PDF	NNP
en-wikipedia-org-4107	454	9	)	)	-RRB-
en-wikipedia-org-4107	454	10	.	.	.
en-wikipedia-org-4107	455	1	Journal	Journal	NNP
en-wikipedia-org-4107	455	2	of	of	IN
en-wikipedia-org-4107	455	3	Biological	Biological	NNP
en-wikipedia-org-4107	455	4	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	455	5	.	.	.
en-wikipedia-org-4107	456	1	249	249	CD
en-wikipedia-org-4107	456	2	(	(	-LRB-
en-wikipedia-org-4107	456	3	2	2	CD
en-wikipedia-org-4107	456	4	)	)	-RRB-
en-wikipedia-org-4107	456	5	:	:	:
en-wikipedia-org-4107	456	6	454–458	454–458	CD
en-wikipedia-org-4107	456	7	.	.	.
en-wikipedia-org-4107	457	1	PMID	PMID	NNP
en-wikipedia-org-4107	457	2	 	  	_SP
en-wikipedia-org-4107	457	3	4809526	4809526	CD
en-wikipedia-org-4107	457	4	.	.	.
en-wikipedia-org-4107	458	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	458	2	6	6	CD
en-wikipedia-org-4107	458	3	November	November	NNP
en-wikipedia-org-4107	458	4	2014	2014	CD
en-wikipedia-org-4107	458	5	.	.	.
en-wikipedia-org-4107	459	1	Dopamine	dopamine	NN
en-wikipedia-org-4107	459	2	-	-	HYPH
en-wikipedia-org-4107	459	3	β	β	NNP
en-wikipedia-org-4107	459	4	-	-	HYPH
en-wikipedia-org-4107	459	5	hydroxylase	hydroxylase	NN
en-wikipedia-org-4107	459	6	catalyzed	catalyze	VBD
en-wikipedia-org-4107	459	7	the	the	DT
en-wikipedia-org-4107	459	8	removal	removal	NN
en-wikipedia-org-4107	459	9	of	of	IN
en-wikipedia-org-4107	459	10	the	the	DT
en-wikipedia-org-4107	459	11	pro	pro	JJ
en-wikipedia-org-4107	459	12	-	-	JJ
en-wikipedia-org-4107	459	13	R	r	JJ
en-wikipedia-org-4107	459	14	hydrogen	hydrogen	NN
en-wikipedia-org-4107	459	15	atom	atom	NN
en-wikipedia-org-4107	459	16	and	and	CC
en-wikipedia-org-4107	459	17	the	the	DT
en-wikipedia-org-4107	459	18	production	production	NN
en-wikipedia-org-4107	459	19	of	of	IN
en-wikipedia-org-4107	459	20	1-norephedrine	1-norephedrine	CD
en-wikipedia-org-4107	459	21	,	,	,
en-wikipedia-org-4107	459	22	(	(	-LRB-
en-wikipedia-org-4107	459	23	2S,1R)-2-amino-1-hydroxyl-1-phenylpropane	2s,1r)-2-amino-1-hydroxyl-1-phenylpropane	CD
en-wikipedia-org-4107	459	24	,	,	,
en-wikipedia-org-4107	459	25	from	from	IN
en-wikipedia-org-4107	459	26	d	d	NNP
en-wikipedia-org-4107	459	27	-	-	HYPH
en-wikipedia-org-4107	459	28	amphetamine	amphetamine	NN
en-wikipedia-org-4107	459	29	.	.	.
en-wikipedia-org-4107	460	1	^	^	NNP
en-wikipedia-org-4107	460	2	a	a	DT
en-wikipedia-org-4107	460	3	b	b	NNP
en-wikipedia-org-4107	460	4	c	c	NN
en-wikipedia-org-4107	460	5	Krueger	Krueger	NNP
en-wikipedia-org-4107	460	6	SK	SK	NNP
en-wikipedia-org-4107	460	7	,	,	,
en-wikipedia-org-4107	460	8	Williams	Williams	NNP
en-wikipedia-org-4107	460	9	DE	DE	NNP
en-wikipedia-org-4107	460	10	(	(	-LRB-
en-wikipedia-org-4107	460	11	June	June	NNP
en-wikipedia-org-4107	460	12	2005	2005	CD
en-wikipedia-org-4107	460	13	)	)	-RRB-
en-wikipedia-org-4107	460	14	.	.	.
en-wikipedia-org-4107	461	1	"	"	``
en-wikipedia-org-4107	461	2	Mammalian	mammalian	JJ
en-wikipedia-org-4107	461	3	flavin	flavin	RB
en-wikipedia-org-4107	461	4	-	-	HYPH
en-wikipedia-org-4107	461	5	containing	contain	VBG
en-wikipedia-org-4107	461	6	monooxygenases	monooxygenase	NNS
en-wikipedia-org-4107	461	7	:	:	:
en-wikipedia-org-4107	461	8	structure	structure	NN
en-wikipedia-org-4107	461	9	/	/	SYM
en-wikipedia-org-4107	461	10	function	function	NN
en-wikipedia-org-4107	461	11	,	,	,
en-wikipedia-org-4107	461	12	genetic	genetic	JJ
en-wikipedia-org-4107	461	13	polymorphisms	polymorphism	NNS
en-wikipedia-org-4107	461	14	and	and	CC
en-wikipedia-org-4107	461	15	role	role	NN
en-wikipedia-org-4107	461	16	in	in	IN
en-wikipedia-org-4107	461	17	drug	drug	NN
en-wikipedia-org-4107	461	18	metabolism	metabolism	NN
en-wikipedia-org-4107	461	19	"	"	''
en-wikipedia-org-4107	461	20	.	.	.
en-wikipedia-org-4107	462	1	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	462	2	&	&	CC
en-wikipedia-org-4107	462	3	Therapeutics	Therapeutics	NNP
en-wikipedia-org-4107	462	4	.	.	.
en-wikipedia-org-4107	463	1	106	106	CD
en-wikipedia-org-4107	463	2	(	(	-LRB-
en-wikipedia-org-4107	463	3	3	3	CD
en-wikipedia-org-4107	463	4	)	)	-RRB-
en-wikipedia-org-4107	463	5	:	:	:
en-wikipedia-org-4107	463	6	357–387	357–387	CD
en-wikipedia-org-4107	463	7	.	.	.
en-wikipedia-org-4107	464	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	464	2	/	/	SYM
en-wikipedia-org-4107	464	3	j.pharmthera.2005.01.001	j.pharmthera.2005.01.001	JJ
en-wikipedia-org-4107	464	4	.	.	.
en-wikipedia-org-4107	465	1	PMC	PMC	NNP
en-wikipedia-org-4107	465	2	 	  	_SP
en-wikipedia-org-4107	465	3	1828602	1828602	CD
en-wikipedia-org-4107	465	4	.	.	.
en-wikipedia-org-4107	466	1	PMID	PMID	NNP
en-wikipedia-org-4107	466	2	 	  	_SP
en-wikipedia-org-4107	466	3	15922018	15922018	CD
en-wikipedia-org-4107	466	4	.	.	.
en-wikipedia-org-4107	467	1	Table	table	NN
en-wikipedia-org-4107	467	2	5	5	CD
en-wikipedia-org-4107	467	3	:	:	:
en-wikipedia-org-4107	467	4	N	n	CD
en-wikipedia-org-4107	467	5	-	-	HYPH
en-wikipedia-org-4107	467	6	containing	contain	VBG
en-wikipedia-org-4107	467	7	drugs	drug	NNS
en-wikipedia-org-4107	467	8	and	and	CC
en-wikipedia-org-4107	467	9	xenobiotics	xenobiotic	NNS
en-wikipedia-org-4107	467	10	oxygenated	oxygenate	VBN
en-wikipedia-org-4107	467	11	by	by	IN
en-wikipedia-org-4107	467	12	FMO	FMO	NNP
en-wikipedia-org-4107	467	13	^	^	NNP
en-wikipedia-org-4107	467	14	a	a	DT
en-wikipedia-org-4107	467	15	b	b	NN
en-wikipedia-org-4107	467	16	Cashman	Cashman	NNP
en-wikipedia-org-4107	467	17	JR	JR	NNP
en-wikipedia-org-4107	467	18	,	,	,
en-wikipedia-org-4107	467	19	Xiong	Xiong	NNP
en-wikipedia-org-4107	467	20	YN	YN	NNP
en-wikipedia-org-4107	467	21	,	,	,
en-wikipedia-org-4107	467	22	Xu	Xu	NNP
en-wikipedia-org-4107	467	23	L	L	NNP
en-wikipedia-org-4107	467	24	,	,	,
en-wikipedia-org-4107	467	25	Janowsky	Janowsky	NNP
en-wikipedia-org-4107	467	26	A	A	NNP
en-wikipedia-org-4107	467	27	(	(	-LRB-
en-wikipedia-org-4107	467	28	March	March	NNP
en-wikipedia-org-4107	467	29	1999	1999	CD
en-wikipedia-org-4107	467	30	)	)	-RRB-
en-wikipedia-org-4107	467	31	.	.	.
en-wikipedia-org-4107	468	1	"	"	``
en-wikipedia-org-4107	468	2	N	n	NN
en-wikipedia-org-4107	468	3	-	-	HYPH
en-wikipedia-org-4107	468	4	oxygenation	oxygenation	NN
en-wikipedia-org-4107	468	5	of	of	IN
en-wikipedia-org-4107	468	6	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	468	7	and	and	CC
en-wikipedia-org-4107	468	8	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	468	9	by	by	IN
en-wikipedia-org-4107	468	10	the	the	DT
en-wikipedia-org-4107	468	11	human	human	JJ
en-wikipedia-org-4107	468	12	flavin	flavin	RB
en-wikipedia-org-4107	468	13	-	-	HYPH
en-wikipedia-org-4107	468	14	containing	contain	VBG
en-wikipedia-org-4107	468	15	monooxygenase	monooxygenase	NN
en-wikipedia-org-4107	468	16	(	(	-LRB-
en-wikipedia-org-4107	468	17	form	form	NN
en-wikipedia-org-4107	468	18	3	3	CD
en-wikipedia-org-4107	468	19	)	)	-RRB-
en-wikipedia-org-4107	468	20	:	:	:
en-wikipedia-org-4107	468	21	role	role	NN
en-wikipedia-org-4107	468	22	in	in	IN
en-wikipedia-org-4107	468	23	bioactivation	bioactivation	NN
en-wikipedia-org-4107	468	24	and	and	CC
en-wikipedia-org-4107	468	25	detoxication	detoxication	NN
en-wikipedia-org-4107	468	26	"	"	''
en-wikipedia-org-4107	468	27	.	.	.
en-wikipedia-org-4107	469	1	Journal	Journal	NNP
en-wikipedia-org-4107	469	2	of	of	IN
en-wikipedia-org-4107	469	3	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	469	4	and	and	CC
en-wikipedia-org-4107	469	5	Experimental	Experimental	NNP
en-wikipedia-org-4107	469	6	Therapeutics	Therapeutics	NNP
en-wikipedia-org-4107	469	7	.	.	.
en-wikipedia-org-4107	470	1	288	288	CD
en-wikipedia-org-4107	470	2	(	(	-LRB-
en-wikipedia-org-4107	470	3	3	3	CD
en-wikipedia-org-4107	470	4	)	)	-RRB-
en-wikipedia-org-4107	470	5	:	:	:
en-wikipedia-org-4107	470	6	1251–1260	1251–1260	CD
en-wikipedia-org-4107	470	7	.	.	.
en-wikipedia-org-4107	471	1	PMID	PMID	NNP
en-wikipedia-org-4107	471	2	 	  	_SP
en-wikipedia-org-4107	471	3	10027866	10027866	CD
en-wikipedia-org-4107	471	4	.	.	.
en-wikipedia-org-4107	472	1	^	^	NNP
en-wikipedia-org-4107	472	2	a	a	DT
en-wikipedia-org-4107	472	3	b	b	NNP
en-wikipedia-org-4107	472	4	c	c	NN
en-wikipedia-org-4107	472	5	d	d	NN
en-wikipedia-org-4107	472	6	e	e	NN
en-wikipedia-org-4107	472	7	Yoshida	Yoshida	NNP
en-wikipedia-org-4107	472	8	T	T	NNP
en-wikipedia-org-4107	472	9	(	(	-LRB-
en-wikipedia-org-4107	472	10	1997	1997	CD
en-wikipedia-org-4107	472	11	)	)	-RRB-
en-wikipedia-org-4107	472	12	.	.	.
en-wikipedia-org-4107	473	1	"	"	``
en-wikipedia-org-4107	473	2	Chapter	chapter	NN
en-wikipedia-org-4107	473	3	1	1	CD
en-wikipedia-org-4107	473	4	:	:	:
en-wikipedia-org-4107	473	5	Use	Use	NNP
en-wikipedia-org-4107	473	6	and	and	CC
en-wikipedia-org-4107	473	7	Misuse	Misuse	NNP
en-wikipedia-org-4107	473	8	of	of	IN
en-wikipedia-org-4107	473	9	Amphetamines	Amphetamines	NNPS
en-wikipedia-org-4107	473	10	:	:	:
en-wikipedia-org-4107	473	11	An	an	DT
en-wikipedia-org-4107	473	12	International	International	NNP
en-wikipedia-org-4107	473	13	Overview	Overview	NNP
en-wikipedia-org-4107	473	14	"	"	''
en-wikipedia-org-4107	473	15	.	.	.
en-wikipedia-org-4107	474	1	In	in	IN
en-wikipedia-org-4107	474	2	Klee	Klee	NNP
en-wikipedia-org-4107	474	3	H	H	NNP
en-wikipedia-org-4107	474	4	(	(	-LRB-
en-wikipedia-org-4107	474	5	ed	ed	NNP
en-wikipedia-org-4107	474	6	.	.	.
en-wikipedia-org-4107	474	7	)	)	-RRB-
en-wikipedia-org-4107	474	8	.	.	.
en-wikipedia-org-4107	475	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	475	2	Misuse	Misuse	NNP
en-wikipedia-org-4107	475	3	:	:	:
en-wikipedia-org-4107	475	4	International	International	NNP
en-wikipedia-org-4107	475	5	Perspectives	Perspectives	NNPS
en-wikipedia-org-4107	475	6	on	on	IN
en-wikipedia-org-4107	475	7	Current	Current	NNP
en-wikipedia-org-4107	475	8	Trends	Trends	NNPS
en-wikipedia-org-4107	475	9	.	.	.
en-wikipedia-org-4107	476	1	Amsterdam	Amsterdam	NNP
en-wikipedia-org-4107	476	2	,	,	,
en-wikipedia-org-4107	476	3	Netherlands	Netherlands	NNP
en-wikipedia-org-4107	476	4	:	:	:
en-wikipedia-org-4107	476	5	Harwood	Harwood	NNP
en-wikipedia-org-4107	476	6	Academic	Academic	NNP
en-wikipedia-org-4107	476	7	Publishers	Publishers	NNPS
en-wikipedia-org-4107	476	8	.	.	.
en-wikipedia-org-4107	477	1	p.	p.	NN
en-wikipedia-org-4107	477	2	 	  	_SP
en-wikipedia-org-4107	477	3	2	2	CD
en-wikipedia-org-4107	477	4	.	.	.
en-wikipedia-org-4107	478	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	478	2	 	  	_SP
en-wikipedia-org-4107	478	3	9789057020810	9789057020810	CD
en-wikipedia-org-4107	478	4	.	.	.
en-wikipedia-org-4107	479	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	479	2	,	,	,
en-wikipedia-org-4107	479	3	in	in	IN
en-wikipedia-org-4107	479	4	the	the	DT
en-wikipedia-org-4107	479	5	singular	singular	JJ
en-wikipedia-org-4107	479	6	form	form	NN
en-wikipedia-org-4107	479	7	,	,	,
en-wikipedia-org-4107	479	8	properly	properly	RB
en-wikipedia-org-4107	479	9	applies	apply	VBZ
en-wikipedia-org-4107	479	10	to	to	IN
en-wikipedia-org-4107	479	11	the	the	DT
en-wikipedia-org-4107	479	12	racemate	racemate	NN
en-wikipedia-org-4107	479	13	of	of	IN
en-wikipedia-org-4107	479	14	2-amino-1-phenylpropane	2-amino-1-phenylpropane	CD
en-wikipedia-org-4107	479	15	.	.	.
en-wikipedia-org-4107	480	1	...	...	NFP
en-wikipedia-org-4107	481	1	In	in	IN
en-wikipedia-org-4107	481	2	its	-PRON-	PRP$
en-wikipedia-org-4107	481	3	broadest	broad	JJS
en-wikipedia-org-4107	481	4	context	context	NN
en-wikipedia-org-4107	481	5	,	,	,
en-wikipedia-org-4107	481	6	however	however	RB
en-wikipedia-org-4107	481	7	,	,	,
en-wikipedia-org-4107	481	8	the	the	DT
en-wikipedia-org-4107	481	9	term	term	NN
en-wikipedia-org-4107	481	10	[	[	-LRB-
en-wikipedia-org-4107	481	11	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	481	12	]	]	-RRB-
en-wikipedia-org-4107	481	13	can	can	MD
en-wikipedia-org-4107	481	14	even	even	RB
en-wikipedia-org-4107	481	15	embrace	embrace	VB
en-wikipedia-org-4107	481	16	a	a	DT
en-wikipedia-org-4107	481	17	large	large	JJ
en-wikipedia-org-4107	481	18	number	number	NN
en-wikipedia-org-4107	481	19	of	of	IN
en-wikipedia-org-4107	481	20	structurally	structurally	RB
en-wikipedia-org-4107	481	21	and	and	CC
en-wikipedia-org-4107	481	22	pharmacologically	pharmacologically	RB
en-wikipedia-org-4107	481	23	related	relate	VBN
en-wikipedia-org-4107	481	24	substances	substance	NNS
en-wikipedia-org-4107	481	25	.	.	.
en-wikipedia-org-4107	482	1	^	^	FW
en-wikipedia-org-4107	482	2	"	"	``
en-wikipedia-org-4107	482	3	Density	Density	NNP
en-wikipedia-org-4107	482	4	"	"	''
en-wikipedia-org-4107	482	5	.	.	.
en-wikipedia-org-4107	483	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	483	2	.	.	.
en-wikipedia-org-4107	484	1	PubChem	PubChem	NNP
en-wikipedia-org-4107	484	2	Compound	Compound	NNP
en-wikipedia-org-4107	484	3	Database	Database	NNP
en-wikipedia-org-4107	484	4	.	.	.
en-wikipedia-org-4107	485	1	United	United	NNP
en-wikipedia-org-4107	485	2	States	States	NNP
en-wikipedia-org-4107	485	3	National	National	NNP
en-wikipedia-org-4107	485	4	Library	Library	NNP
en-wikipedia-org-4107	485	5	of	of	IN
en-wikipedia-org-4107	485	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	485	7	 	  	_SP
en-wikipedia-org-4107	485	8	–	–	:
en-wikipedia-org-4107	485	9	National	National	NNP
en-wikipedia-org-4107	485	10	Center	Center	NNP
en-wikipedia-org-4107	485	11	for	for	IN
en-wikipedia-org-4107	485	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	485	13	Information	Information	NNP
en-wikipedia-org-4107	485	14	.	.	.
en-wikipedia-org-4107	486	1	5	5	CD
en-wikipedia-org-4107	486	2	November	November	NNP
en-wikipedia-org-4107	486	3	2016	2016	CD
en-wikipedia-org-4107	486	4	.	.	.
en-wikipedia-org-4107	487	1	Retrieved	retrieved	JJ
en-wikipedia-org-4107	487	2	9	9	CD
en-wikipedia-org-4107	487	3	November	November	NNP
en-wikipedia-org-4107	487	4	2016	2016	CD
en-wikipedia-org-4107	487	5	.	.	.
en-wikipedia-org-4107	488	1	^	^	FW
en-wikipedia-org-4107	488	2	"	"	``
en-wikipedia-org-4107	488	3	Properties	property	NNS
en-wikipedia-org-4107	488	4	:	:	:
en-wikipedia-org-4107	488	5	Predicted	predict	VBN
en-wikipedia-org-4107	488	6	–	–	:
en-wikipedia-org-4107	488	7	EPISuite	EPISuite	NNP
en-wikipedia-org-4107	488	8	"	"	''
en-wikipedia-org-4107	488	9	.	.	.
en-wikipedia-org-4107	489	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	489	2	.	.	.
en-wikipedia-org-4107	490	1	ChemSpider	ChemSpider	NNP
en-wikipedia-org-4107	490	2	.	.	.
en-wikipedia-org-4107	491	1	Royal	Royal	NNP
en-wikipedia-org-4107	491	2	Society	Society	NNP
en-wikipedia-org-4107	491	3	of	of	IN
en-wikipedia-org-4107	491	4	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	491	5	.	.	.
en-wikipedia-org-4107	492	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	492	2	6	6	CD
en-wikipedia-org-4107	492	3	November	November	NNP
en-wikipedia-org-4107	492	4	2013	2013	CD
en-wikipedia-org-4107	492	5	.	.	.
en-wikipedia-org-4107	493	1	^	^	NNP
en-wikipedia-org-4107	493	2	a	a	DT
en-wikipedia-org-4107	493	3	b	b	NNP
en-wikipedia-org-4107	493	4	"	"	``
en-wikipedia-org-4107	493	5	Chemical	Chemical	NNP
en-wikipedia-org-4107	493	6	and	and	CC
en-wikipedia-org-4107	493	7	Physical	Physical	NNP
en-wikipedia-org-4107	493	8	Properties	Properties	NNPS
en-wikipedia-org-4107	493	9	"	"	''
en-wikipedia-org-4107	493	10	.	.	.
en-wikipedia-org-4107	494	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	494	2	.	.	.
en-wikipedia-org-4107	495	1	PubChem	PubChem	NNP
en-wikipedia-org-4107	495	2	Compound	Compound	NNP
en-wikipedia-org-4107	495	3	Database	Database	NNP
en-wikipedia-org-4107	495	4	.	.	.
en-wikipedia-org-4107	496	1	United	United	NNP
en-wikipedia-org-4107	496	2	States	States	NNP
en-wikipedia-org-4107	496	3	National	National	NNP
en-wikipedia-org-4107	496	4	Library	Library	NNP
en-wikipedia-org-4107	496	5	of	of	IN
en-wikipedia-org-4107	496	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	496	7	 	  	_SP
en-wikipedia-org-4107	496	8	–	–	:
en-wikipedia-org-4107	496	9	National	National	NNP
en-wikipedia-org-4107	496	10	Center	Center	NNP
en-wikipedia-org-4107	496	11	for	for	IN
en-wikipedia-org-4107	496	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	496	13	Information	Information	NNP
en-wikipedia-org-4107	496	14	.	.	.
en-wikipedia-org-4107	497	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	497	2	13	13	CD
en-wikipedia-org-4107	497	3	October	October	NNP
en-wikipedia-org-4107	497	4	2013	2013	CD
en-wikipedia-org-4107	497	5	.	.	.
en-wikipedia-org-4107	498	1	^	^	NNP
en-wikipedia-org-4107	498	2	a	a	DT
en-wikipedia-org-4107	498	3	b	b	NNP
en-wikipedia-org-4107	498	4	c	c	NN
en-wikipedia-org-4107	498	5	"	"	``
en-wikipedia-org-4107	498	6	Compound	Compound	NNP
en-wikipedia-org-4107	498	7	Summary	Summary	NNP
en-wikipedia-org-4107	498	8	"	"	''
en-wikipedia-org-4107	498	9	.	.	.
en-wikipedia-org-4107	499	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	499	2	.	.	.
en-wikipedia-org-4107	500	1	PubChem	PubChem	NNP
en-wikipedia-org-4107	500	2	Compound	Compound	NNP
en-wikipedia-org-4107	500	3	Database	Database	NNP
en-wikipedia-org-4107	500	4	.	.	.
en-wikipedia-org-4107	501	1	United	United	NNP
en-wikipedia-org-4107	501	2	States	States	NNP
en-wikipedia-org-4107	501	3	National	National	NNP
en-wikipedia-org-4107	501	4	Library	Library	NNP
en-wikipedia-org-4107	501	5	of	of	IN
en-wikipedia-org-4107	501	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	501	7	 	  	_SP
en-wikipedia-org-4107	501	8	–	–	:
en-wikipedia-org-4107	501	9	National	National	NNP
en-wikipedia-org-4107	501	10	Center	Center	NNP
en-wikipedia-org-4107	501	11	for	for	IN
en-wikipedia-org-4107	501	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	501	13	Information	Information	NNP
en-wikipedia-org-4107	501	14	.	.	.
en-wikipedia-org-4107	502	1	11	11	CD
en-wikipedia-org-4107	502	2	April	April	NNP
en-wikipedia-org-4107	502	3	2015	2015	CD
en-wikipedia-org-4107	502	4	.	.	.
en-wikipedia-org-4107	503	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	503	2	17	17	CD
en-wikipedia-org-4107	503	3	April	April	NNP
en-wikipedia-org-4107	503	4	2015	2015	CD
en-wikipedia-org-4107	503	5	.	.	.
en-wikipedia-org-4107	504	1	^	^	NNP
en-wikipedia-org-4107	504	2	a	a	DT
en-wikipedia-org-4107	504	3	b	b	NN
en-wikipedia-org-4107	504	4	c	c	NN
en-wikipedia-org-4107	504	5	d	d	NN
en-wikipedia-org-4107	504	6	"	"	``
en-wikipedia-org-4107	504	7	Identification	Identification	NNP
en-wikipedia-org-4107	504	8	"	"	''
en-wikipedia-org-4107	504	9	.	.	.
en-wikipedia-org-4107	505	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	505	2	.	.	.
en-wikipedia-org-4107	506	1	DrugBank	DrugBank	NNP
en-wikipedia-org-4107	506	2	.	.	.
en-wikipedia-org-4107	507	1	University	University	NNP
en-wikipedia-org-4107	507	2	of	of	IN
en-wikipedia-org-4107	507	3	Alberta	Alberta	NNP
en-wikipedia-org-4107	507	4	.	.	.
en-wikipedia-org-4107	508	1	8	8	CD
en-wikipedia-org-4107	508	2	February	February	NNP
en-wikipedia-org-4107	508	3	2013	2013	CD
en-wikipedia-org-4107	508	4	.	.	.
en-wikipedia-org-4107	509	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	509	2	13	13	CD
en-wikipedia-org-4107	509	3	October	October	NNP
en-wikipedia-org-4107	509	4	2013	2013	CD
en-wikipedia-org-4107	509	5	.	.	.
en-wikipedia-org-4107	510	1	^	^	NNP
en-wikipedia-org-4107	510	2	a	a	DT
en-wikipedia-org-4107	510	3	b	b	NN
en-wikipedia-org-4107	510	4	Greene	Greene	NNP
en-wikipedia-org-4107	510	5	SL	SL	NNP
en-wikipedia-org-4107	510	6	,	,	,
en-wikipedia-org-4107	510	7	Kerr	Kerr	NNP
en-wikipedia-org-4107	510	8	F	F	NNP
en-wikipedia-org-4107	510	9	,	,	,
en-wikipedia-org-4107	510	10	Braitberg	Braitberg	NNP
en-wikipedia-org-4107	510	11	G	G	NNP
en-wikipedia-org-4107	510	12	(	(	-LRB-
en-wikipedia-org-4107	510	13	October	October	NNP
en-wikipedia-org-4107	510	14	2008	2008	CD
en-wikipedia-org-4107	510	15	)	)	-RRB-
en-wikipedia-org-4107	510	16	.	.	.
en-wikipedia-org-4107	511	1	"	"	``
en-wikipedia-org-4107	511	2	Review	review	NN
en-wikipedia-org-4107	511	3	article	article	NN
en-wikipedia-org-4107	511	4	:	:	:
en-wikipedia-org-4107	511	5	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	511	6	and	and	CC
en-wikipedia-org-4107	511	7	related	relate	VBN
en-wikipedia-org-4107	511	8	drugs	drug	NNS
en-wikipedia-org-4107	511	9	of	of	IN
en-wikipedia-org-4107	511	10	abuse	abuse	NN
en-wikipedia-org-4107	511	11	"	"	''
en-wikipedia-org-4107	511	12	.	.	.
en-wikipedia-org-4107	512	1	Emergency	emergency	NN
en-wikipedia-org-4107	512	2	Medicine	Medicine	NNP
en-wikipedia-org-4107	512	3	Australasia	Australasia	NNP
en-wikipedia-org-4107	512	4	.	.	.
en-wikipedia-org-4107	513	1	20	20	CD
en-wikipedia-org-4107	513	2	(	(	-LRB-
en-wikipedia-org-4107	513	3	5	5	CD
en-wikipedia-org-4107	513	4	)	)	-RRB-
en-wikipedia-org-4107	513	5	:	:	:
en-wikipedia-org-4107	513	6	391–402	391–402	CD
en-wikipedia-org-4107	513	7	.	.	.
en-wikipedia-org-4107	514	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-4107	514	2	/	/	SYM
en-wikipedia-org-4107	514	3	j.1742	j.1742	NNP
en-wikipedia-org-4107	514	4	-	-	HYPH
en-wikipedia-org-4107	514	5	6723.2008.01114.x	6723.2008.01114.x	NNP
en-wikipedia-org-4107	514	6	.	.	.
en-wikipedia-org-4107	515	1	PMID	PMID	NNP
en-wikipedia-org-4107	515	2	 	  	_SP
en-wikipedia-org-4107	515	3	18973636	18973636	CD
en-wikipedia-org-4107	515	4	.	.	.
en-wikipedia-org-4107	516	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	516	2	 	  	_SP
en-wikipedia-org-4107	516	3	20755466	20755466	CD
en-wikipedia-org-4107	516	4	.	.	.
en-wikipedia-org-4107	517	1	^	^	NNP
en-wikipedia-org-4107	517	2	a	a	DT
en-wikipedia-org-4107	517	3	b	b	NNP
en-wikipedia-org-4107	517	4	"	"	``
en-wikipedia-org-4107	517	5	Enantiomer	Enantiomer	NNP
en-wikipedia-org-4107	517	6	"	"	''
en-wikipedia-org-4107	517	7	.	.	.
en-wikipedia-org-4107	518	1	IUPAC	IUPAC	NNP
en-wikipedia-org-4107	518	2	Compendium	Compendium	NNP
en-wikipedia-org-4107	518	3	of	of	IN
en-wikipedia-org-4107	518	4	Chemical	Chemical	NNP
en-wikipedia-org-4107	518	5	Terminology	Terminology	NNP
en-wikipedia-org-4107	518	6	.	.	.
en-wikipedia-org-4107	519	1	IUPAC	IUPAC	NNP
en-wikipedia-org-4107	519	2	Goldbook	Goldbook	NNP
en-wikipedia-org-4107	519	3	.	.	.
en-wikipedia-org-4107	520	1	International	International	NNP
en-wikipedia-org-4107	520	2	Union	Union	NNP
en-wikipedia-org-4107	520	3	of	of	IN
en-wikipedia-org-4107	520	4	Pure	Pure	NNP
en-wikipedia-org-4107	520	5	and	and	CC
en-wikipedia-org-4107	520	6	Applied	Applied	NNP
en-wikipedia-org-4107	520	7	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	520	8	.	.	.
en-wikipedia-org-4107	521	1	2009	2009	CD
en-wikipedia-org-4107	521	2	.	.	.
en-wikipedia-org-4107	521	3	doi:10.1351	doi:10.1351	NNP
en-wikipedia-org-4107	521	4	/	/	SYM
en-wikipedia-org-4107	521	5	goldbook	goldbook	NN
en-wikipedia-org-4107	521	6	.	.	.
en-wikipedia-org-4107	521	7	E02069	E02069	NNP
en-wikipedia-org-4107	521	8	.	.	.
en-wikipedia-org-4107	522	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	522	2	 	  	_SP
en-wikipedia-org-4107	522	3	9780967855097	9780967855097	CD
en-wikipedia-org-4107	522	4	.	.	.
en-wikipedia-org-4107	523	1	Archived	archived	JJ
en-wikipedia-org-4107	523	2	from	from	IN
en-wikipedia-org-4107	523	3	the	the	DT
en-wikipedia-org-4107	523	4	original	original	NN
en-wikipedia-org-4107	523	5	on	on	IN
en-wikipedia-org-4107	523	6	17	17	CD
en-wikipedia-org-4107	523	7	March	March	NNP
en-wikipedia-org-4107	523	8	2013	2013	CD
en-wikipedia-org-4107	523	9	.	.	.
en-wikipedia-org-4107	524	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	524	2	14	14	CD
en-wikipedia-org-4107	524	3	March	March	NNP
en-wikipedia-org-4107	524	4	2014	2014	CD
en-wikipedia-org-4107	524	5	.	.	.
en-wikipedia-org-4107	525	1	One	one	CD
en-wikipedia-org-4107	525	2	of	of	IN
en-wikipedia-org-4107	525	3	a	a	DT
en-wikipedia-org-4107	525	4	pair	pair	NN
en-wikipedia-org-4107	525	5	of	of	IN
en-wikipedia-org-4107	525	6	molecular	molecular	JJ
en-wikipedia-org-4107	525	7	entities	entity	NNS
en-wikipedia-org-4107	525	8	which	which	WDT
en-wikipedia-org-4107	525	9	are	be	VBP
en-wikipedia-org-4107	525	10	mirror	mirror	NN
en-wikipedia-org-4107	525	11	images	image	NNS
en-wikipedia-org-4107	525	12	of	of	IN
en-wikipedia-org-4107	525	13	each	each	DT
en-wikipedia-org-4107	525	14	other	other	JJ
en-wikipedia-org-4107	525	15	and	and	CC
en-wikipedia-org-4107	525	16	non	non	JJ
en-wikipedia-org-4107	525	17	-	-	JJ
en-wikipedia-org-4107	525	18	superposable	superposable	JJ
en-wikipedia-org-4107	525	19	.	.	.
en-wikipedia-org-4107	526	1	^	^	NNP
en-wikipedia-org-4107	526	2	a	a	DT
en-wikipedia-org-4107	526	3	b	b	NNP
en-wikipedia-org-4107	526	4	c	c	NNP
en-wikipedia-org-4107	526	5	d	d	NNP
en-wikipedia-org-4107	526	6	e	e	NNP
en-wikipedia-org-4107	526	7	f	f	NNP
en-wikipedia-org-4107	526	8	g	g	NNP
en-wikipedia-org-4107	526	9	h	h	NNP
en-wikipedia-org-4107	526	10	i	i	NN
en-wikipedia-org-4107	526	11	j	j	NNP
en-wikipedia-org-4107	526	12	Malenka	Malenka	NNP
en-wikipedia-org-4107	526	13	RC	RC	NNP
en-wikipedia-org-4107	526	14	,	,	,
en-wikipedia-org-4107	526	15	Nestler	Nestler	NNP
en-wikipedia-org-4107	526	16	EJ	EJ	NNP
en-wikipedia-org-4107	526	17	,	,	,
en-wikipedia-org-4107	526	18	Hyman	Hyman	NNP
en-wikipedia-org-4107	526	19	SE	SE	NNP
en-wikipedia-org-4107	526	20	(	(	-LRB-
en-wikipedia-org-4107	526	21	2009	2009	CD
en-wikipedia-org-4107	526	22	)	)	-RRB-
en-wikipedia-org-4107	526	23	.	.	.
en-wikipedia-org-4107	527	1	"	"	``
en-wikipedia-org-4107	527	2	Chapter	chapter	NN
en-wikipedia-org-4107	527	3	13	13	CD
en-wikipedia-org-4107	527	4	:	:	:
en-wikipedia-org-4107	527	5	Higher	high	JJR
en-wikipedia-org-4107	527	6	Cognitive	Cognitive	NNP
en-wikipedia-org-4107	527	7	Function	Function	NNP
en-wikipedia-org-4107	527	8	and	and	CC
en-wikipedia-org-4107	527	9	Behavioral	Behavioral	NNP
en-wikipedia-org-4107	527	10	Control	Control	NNP
en-wikipedia-org-4107	527	11	"	"	''
en-wikipedia-org-4107	527	12	.	.	.
en-wikipedia-org-4107	528	1	In	in	IN
en-wikipedia-org-4107	528	2	Sydor	Sydor	NNP
en-wikipedia-org-4107	528	3	A	A	NNP
en-wikipedia-org-4107	528	4	,	,	,
en-wikipedia-org-4107	528	5	Brown	Brown	NNP
en-wikipedia-org-4107	528	6	RY	RY	NNP
en-wikipedia-org-4107	528	7	(	(	-LRB-
en-wikipedia-org-4107	528	8	eds	eds	NNP
en-wikipedia-org-4107	528	9	.	.	.
en-wikipedia-org-4107	528	10	)	)	-RRB-
en-wikipedia-org-4107	528	11	.	.	.
en-wikipedia-org-4107	529	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	529	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-4107	529	3	:	:	:
en-wikipedia-org-4107	529	4	A	A	NNP
en-wikipedia-org-4107	529	5	Foundation	Foundation	NNP
en-wikipedia-org-4107	529	6	for	for	IN
en-wikipedia-org-4107	529	7	Clinical	Clinical	NNP
en-wikipedia-org-4107	529	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	529	9	(	(	-LRB-
en-wikipedia-org-4107	529	10	2nd	2nd	NNP
en-wikipedia-org-4107	529	11	ed	ed	NNP
en-wikipedia-org-4107	529	12	.	.	.
en-wikipedia-org-4107	529	13	)	)	-RRB-
en-wikipedia-org-4107	529	14	.	.	.
en-wikipedia-org-4107	530	1	New	New	NNP
en-wikipedia-org-4107	530	2	York	York	NNP
en-wikipedia-org-4107	530	3	,	,	,
en-wikipedia-org-4107	530	4	USA	USA	NNP
en-wikipedia-org-4107	530	5	:	:	:
en-wikipedia-org-4107	530	6	McGraw	McGraw	NNP
en-wikipedia-org-4107	530	7	-	-	HYPH
en-wikipedia-org-4107	530	8	Hill	Hill	NNP
en-wikipedia-org-4107	530	9	Medical	Medical	NNP
en-wikipedia-org-4107	530	10	.	.	.
en-wikipedia-org-4107	531	1	pp	pp	NNP
en-wikipedia-org-4107	531	2	.	.	.
en-wikipedia-org-4107	532	1	318	318	CD
en-wikipedia-org-4107	532	2	,	,	,
en-wikipedia-org-4107	532	3	321	321	CD
en-wikipedia-org-4107	532	4	.	.	.
en-wikipedia-org-4107	533	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	533	2	 	  	_SP
en-wikipedia-org-4107	533	3	9780071481274	9780071481274	CD
en-wikipedia-org-4107	533	4	.	.	.
en-wikipedia-org-4107	534	1	Therapeutic	therapeutic	JJ
en-wikipedia-org-4107	534	2	(	(	-LRB-
en-wikipedia-org-4107	534	3	relatively	relatively	RB
en-wikipedia-org-4107	534	4	low	low	JJ
en-wikipedia-org-4107	534	5	)	)	-RRB-
en-wikipedia-org-4107	534	6	doses	dose	NNS
en-wikipedia-org-4107	534	7	of	of	IN
en-wikipedia-org-4107	534	8	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	534	9	,	,	,
en-wikipedia-org-4107	534	10	such	such	JJ
en-wikipedia-org-4107	534	11	as	as	IN
en-wikipedia-org-4107	534	12	methylphenidate	methylphenidate	NN
en-wikipedia-org-4107	534	13	and	and	CC
en-wikipedia-org-4107	534	14	amphetamine	amphetamine	VB
en-wikipedia-org-4107	534	15	,	,	,
en-wikipedia-org-4107	534	16	improve	improve	VB
en-wikipedia-org-4107	534	17	performance	performance	NN
en-wikipedia-org-4107	534	18	on	on	IN
en-wikipedia-org-4107	534	19	working	work	VBG
en-wikipedia-org-4107	534	20	memory	memory	NN
en-wikipedia-org-4107	534	21	tasks	task	NNS
en-wikipedia-org-4107	534	22	both	both	DT
en-wikipedia-org-4107	534	23	in	in	IN
en-wikipedia-org-4107	534	24	normal	normal	JJ
en-wikipedia-org-4107	534	25	subjects	subject	NNS
en-wikipedia-org-4107	534	26	and	and	CC
en-wikipedia-org-4107	534	27	those	those	DT
en-wikipedia-org-4107	534	28	with	with	IN
en-wikipedia-org-4107	534	29	ADHD	ADHD	NNP
en-wikipedia-org-4107	534	30	.	.	.
en-wikipedia-org-4107	535	1	...	...	NFP
en-wikipedia-org-4107	535	2	stimulants	stimulants	NNP
en-wikipedia-org-4107	535	3	act	act	VBP
en-wikipedia-org-4107	535	4	not	not	RB
en-wikipedia-org-4107	535	5	only	only	RB
en-wikipedia-org-4107	535	6	on	on	IN
en-wikipedia-org-4107	535	7	working	work	VBG
en-wikipedia-org-4107	535	8	memory	memory	NN
en-wikipedia-org-4107	535	9	function	function	NN
en-wikipedia-org-4107	535	10	,	,	,
en-wikipedia-org-4107	535	11	but	but	CC
en-wikipedia-org-4107	535	12	also	also	RB
en-wikipedia-org-4107	535	13	on	on	IN
en-wikipedia-org-4107	535	14	general	general	JJ
en-wikipedia-org-4107	535	15	levels	level	NNS
en-wikipedia-org-4107	535	16	of	of	IN
en-wikipedia-org-4107	535	17	arousal	arousal	NN
en-wikipedia-org-4107	535	18	and	and	CC
en-wikipedia-org-4107	535	19	,	,	,
en-wikipedia-org-4107	535	20	within	within	IN
en-wikipedia-org-4107	535	21	the	the	DT
en-wikipedia-org-4107	535	22	nucleus	nucleus	NN
en-wikipedia-org-4107	535	23	accumbens	accumbens	NNPS
en-wikipedia-org-4107	535	24	,	,	,
en-wikipedia-org-4107	535	25	improve	improve	VB
en-wikipedia-org-4107	535	26	the	the	DT
en-wikipedia-org-4107	535	27	saliency	saliency	NN
en-wikipedia-org-4107	535	28	of	of	IN
en-wikipedia-org-4107	535	29	tasks	task	NNS
en-wikipedia-org-4107	535	30	.	.	.
en-wikipedia-org-4107	536	1	Thus	thus	RB
en-wikipedia-org-4107	536	2	,	,	,
en-wikipedia-org-4107	536	3	stimulants	stimulant	NNS
en-wikipedia-org-4107	536	4	improve	improve	VBP
en-wikipedia-org-4107	536	5	performance	performance	NN
en-wikipedia-org-4107	536	6	on	on	IN
en-wikipedia-org-4107	536	7	effortful	effortful	JJ
en-wikipedia-org-4107	536	8	but	but	CC
en-wikipedia-org-4107	536	9	tedious	tedious	JJ
en-wikipedia-org-4107	536	10	tasks	task	NNS
en-wikipedia-org-4107	536	11	 	  	_SP
en-wikipedia-org-4107	536	12	...	...	NFP
en-wikipedia-org-4107	536	13	through	through	IN
en-wikipedia-org-4107	536	14	indirect	indirect	JJ
en-wikipedia-org-4107	536	15	stimulation	stimulation	NN
en-wikipedia-org-4107	536	16	of	of	IN
en-wikipedia-org-4107	536	17	dopamine	dopamine	NN
en-wikipedia-org-4107	536	18	and	and	CC
en-wikipedia-org-4107	536	19	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	536	20	receptors	receptor	NNS
en-wikipedia-org-4107	536	21	.	.	.
en-wikipedia-org-4107	537	1	...	...	NFP
en-wikipedia-org-4107	538	1	Beyond	beyond	IN
en-wikipedia-org-4107	538	2	these	these	DT
en-wikipedia-org-4107	538	3	general	general	JJ
en-wikipedia-org-4107	538	4	permissive	permissive	JJ
en-wikipedia-org-4107	538	5	effects	effect	NNS
en-wikipedia-org-4107	538	6	,	,	,
en-wikipedia-org-4107	538	7	dopamine	dopamine	NN
en-wikipedia-org-4107	538	8	(	(	-LRB-
en-wikipedia-org-4107	538	9	acting	act	VBG
en-wikipedia-org-4107	538	10	via	via	IN
en-wikipedia-org-4107	538	11	D1	d1	NN
en-wikipedia-org-4107	538	12	receptors	receptor	NNS
en-wikipedia-org-4107	538	13	)	)	-RRB-
en-wikipedia-org-4107	538	14	and	and	CC
en-wikipedia-org-4107	538	15	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	538	16	(	(	-LRB-
en-wikipedia-org-4107	538	17	acting	act	VBG
en-wikipedia-org-4107	538	18	at	at	IN
en-wikipedia-org-4107	538	19	several	several	JJ
en-wikipedia-org-4107	538	20	receptors	receptor	NNS
en-wikipedia-org-4107	538	21	)	)	-RRB-
en-wikipedia-org-4107	538	22	can	can	MD
en-wikipedia-org-4107	538	23	,	,	,
en-wikipedia-org-4107	538	24	at	at	IN
en-wikipedia-org-4107	538	25	optimal	optimal	JJ
en-wikipedia-org-4107	538	26	levels	level	NNS
en-wikipedia-org-4107	538	27	,	,	,
en-wikipedia-org-4107	538	28	enhance	enhance	VB
en-wikipedia-org-4107	538	29	working	work	VBG
en-wikipedia-org-4107	538	30	memory	memory	NN
en-wikipedia-org-4107	538	31	and	and	CC
en-wikipedia-org-4107	538	32	aspects	aspect	NNS
en-wikipedia-org-4107	538	33	of	of	IN
en-wikipedia-org-4107	538	34	attention	attention	NN
en-wikipedia-org-4107	538	35	.	.	.
en-wikipedia-org-4107	539	1	^	^	NNP
en-wikipedia-org-4107	539	2	a	a	DT
en-wikipedia-org-4107	539	3	b	b	NNP
en-wikipedia-org-4107	539	4	c	c	NNP
en-wikipedia-org-4107	539	5	d	d	NNP
en-wikipedia-org-4107	539	6	e	e	NNP
en-wikipedia-org-4107	539	7	f	f	NNP
en-wikipedia-org-4107	539	8	g	g	NNP
en-wikipedia-org-4107	539	9	Liddle	Liddle	NNP
en-wikipedia-org-4107	539	10	DG	DG	NNP
en-wikipedia-org-4107	539	11	,	,	,
en-wikipedia-org-4107	539	12	Connor	Connor	NNP
en-wikipedia-org-4107	539	13	DJ	DJ	NNP
en-wikipedia-org-4107	539	14	(	(	-LRB-
en-wikipedia-org-4107	539	15	June	June	NNP
en-wikipedia-org-4107	539	16	2013	2013	CD
en-wikipedia-org-4107	539	17	)	)	-RRB-
en-wikipedia-org-4107	539	18	.	.	.
en-wikipedia-org-4107	540	1	"	"	``
en-wikipedia-org-4107	540	2	Nutritional	nutritional	JJ
en-wikipedia-org-4107	540	3	supplements	supplement	NNS
en-wikipedia-org-4107	540	4	and	and	CC
en-wikipedia-org-4107	540	5	ergogenic	ergogenic	JJ
en-wikipedia-org-4107	540	6	AIDS	AIDS	NNP
en-wikipedia-org-4107	540	7	"	"	''
en-wikipedia-org-4107	540	8	.	.	.
en-wikipedia-org-4107	541	1	Primary	primary	JJ
en-wikipedia-org-4107	541	2	Care	care	NN
en-wikipedia-org-4107	541	3	:	:	:
en-wikipedia-org-4107	541	4	Clinics	Clinics	NNP
en-wikipedia-org-4107	541	5	in	in	IN
en-wikipedia-org-4107	541	6	Office	Office	NNP
en-wikipedia-org-4107	541	7	Practice	Practice	NNP
en-wikipedia-org-4107	541	8	.	.	.
en-wikipedia-org-4107	542	1	40	40	CD
en-wikipedia-org-4107	542	2	(	(	-LRB-
en-wikipedia-org-4107	542	3	2	2	CD
en-wikipedia-org-4107	542	4	)	)	-RRB-
en-wikipedia-org-4107	542	5	:	:	:
en-wikipedia-org-4107	542	6	487–505	487–505	CD
en-wikipedia-org-4107	542	7	.	.	.
en-wikipedia-org-4107	543	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	543	2	/	/	SYM
en-wikipedia-org-4107	543	3	j.pop.2013.02.009	j.pop.2013.02.009	NN
en-wikipedia-org-4107	543	4	.	.	.
en-wikipedia-org-4107	544	1	PMID	PMID	NNP
en-wikipedia-org-4107	544	2	 	  	_SP
en-wikipedia-org-4107	544	3	23668655	23668655	CD
en-wikipedia-org-4107	544	4	.	.	.
en-wikipedia-org-4107	545	1	Amphetamines	amphetamine	NNS
en-wikipedia-org-4107	545	2	and	and	CC
en-wikipedia-org-4107	545	3	caffeine	caffeine	NN
en-wikipedia-org-4107	545	4	are	be	VBP
en-wikipedia-org-4107	545	5	stimulants	stimulant	NNS
en-wikipedia-org-4107	545	6	that	that	WDT
en-wikipedia-org-4107	545	7	increase	increase	VBP
en-wikipedia-org-4107	545	8	alertness	alertness	NN
en-wikipedia-org-4107	545	9	,	,	,
en-wikipedia-org-4107	545	10	improve	improve	VB
en-wikipedia-org-4107	545	11	focus	focus	NN
en-wikipedia-org-4107	545	12	,	,	,
en-wikipedia-org-4107	545	13	decrease	decrease	NN
en-wikipedia-org-4107	545	14	reaction	reaction	NN
en-wikipedia-org-4107	545	15	time	time	NN
en-wikipedia-org-4107	545	16	,	,	,
en-wikipedia-org-4107	545	17	and	and	CC
en-wikipedia-org-4107	545	18	delay	delay	NN
en-wikipedia-org-4107	545	19	fatigue	fatigue	NN
en-wikipedia-org-4107	545	20	,	,	,
en-wikipedia-org-4107	545	21	allowing	allow	VBG
en-wikipedia-org-4107	545	22	for	for	IN
en-wikipedia-org-4107	545	23	an	an	DT
en-wikipedia-org-4107	545	24	increased	increase	VBN
en-wikipedia-org-4107	545	25	intensity	intensity	NN
en-wikipedia-org-4107	545	26	and	and	CC
en-wikipedia-org-4107	545	27	duration	duration	NN
en-wikipedia-org-4107	545	28	of	of	IN
en-wikipedia-org-4107	545	29	training	training	NN
en-wikipedia-org-4107	545	30	 	  	_SP
en-wikipedia-org-4107	545	31	...	...	:
en-wikipedia-org-4107	545	32	Physiologic	physiologic	NN
en-wikipedia-org-4107	545	33	and	and	CC
en-wikipedia-org-4107	545	34	performance	performance	NN
en-wikipedia-org-4107	545	35	effects	effect	NNS
en-wikipedia-org-4107	545	36	 	  	_SP
en-wikipedia-org-4107	545	37	•	•	NNP
en-wikipedia-org-4107	545	38	Amphetamines	Amphetamines	NNPS
en-wikipedia-org-4107	545	39	increase	increase	VBP
en-wikipedia-org-4107	545	40	dopamine	dopamine	NN
en-wikipedia-org-4107	545	41	/	/	SYM
en-wikipedia-org-4107	545	42	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	545	43	release	release	NN
en-wikipedia-org-4107	545	44	and	and	CC
en-wikipedia-org-4107	545	45	inhibit	inhibit	VB
en-wikipedia-org-4107	545	46	their	-PRON-	PRP$
en-wikipedia-org-4107	545	47	reuptake	reuptake	NN
en-wikipedia-org-4107	545	48	,	,	,
en-wikipedia-org-4107	545	49	leading	lead	VBG
en-wikipedia-org-4107	545	50	to	to	IN
en-wikipedia-org-4107	545	51	central	central	JJ
en-wikipedia-org-4107	545	52	nervous	nervous	JJ
en-wikipedia-org-4107	545	53	system	system	NN
en-wikipedia-org-4107	545	54	(	(	-LRB-
en-wikipedia-org-4107	545	55	CNS	cns	NN
en-wikipedia-org-4107	545	56	)	)	-RRB-
en-wikipedia-org-4107	545	57	stimulation	stimulation	NN
en-wikipedia-org-4107	545	58	 	  	_SP
en-wikipedia-org-4107	545	59	•	•	NNP
en-wikipedia-org-4107	545	60	Amphetamines	amphetamine	NNS
en-wikipedia-org-4107	545	61	seem	seem	VBP
en-wikipedia-org-4107	545	62	to	to	TO
en-wikipedia-org-4107	545	63	enhance	enhance	VB
en-wikipedia-org-4107	545	64	athletic	athletic	JJ
en-wikipedia-org-4107	545	65	performance	performance	NN
en-wikipedia-org-4107	545	66	in	in	IN
en-wikipedia-org-4107	545	67	anaerobic	anaerobic	JJ
en-wikipedia-org-4107	545	68	conditions	condition	NNS
en-wikipedia-org-4107	545	69	39	39	CD
en-wikipedia-org-4107	545	70	40	40	CD
en-wikipedia-org-4107	545	71	 	  	_SP
en-wikipedia-org-4107	545	72	•	•	NN
en-wikipedia-org-4107	545	73	Improved	improved	JJ
en-wikipedia-org-4107	545	74	reaction	reaction	NN
en-wikipedia-org-4107	545	75	time	time	NN
en-wikipedia-org-4107	545	76	 	  	_SP
en-wikipedia-org-4107	545	77	•	•	NNP
en-wikipedia-org-4107	545	78	Increased	increase	VBN
en-wikipedia-org-4107	545	79	muscle	muscle	NN
en-wikipedia-org-4107	545	80	strength	strength	NN
en-wikipedia-org-4107	545	81	and	and	CC
en-wikipedia-org-4107	545	82	delayed	delay	VBN
en-wikipedia-org-4107	545	83	muscle	muscle	NN
en-wikipedia-org-4107	545	84	fatigue	fatigue	NN
en-wikipedia-org-4107	545	85	 	  	_SP
en-wikipedia-org-4107	545	86	•	•	NNP
en-wikipedia-org-4107	545	87	Increased	increase	VBN
en-wikipedia-org-4107	545	88	acceleration	acceleration	NN
en-wikipedia-org-4107	545	89	 	  	_SP
en-wikipedia-org-4107	545	90	•	•	NNP
en-wikipedia-org-4107	545	91	Increased	increase	VBN
en-wikipedia-org-4107	545	92	alertness	alertness	NN
en-wikipedia-org-4107	545	93	and	and	CC
en-wikipedia-org-4107	545	94	attention	attention	NN
en-wikipedia-org-4107	545	95	to	to	IN
en-wikipedia-org-4107	545	96	task	task	NN
en-wikipedia-org-4107	545	97	^	^	NNP
en-wikipedia-org-4107	545	98	a	a	DT
en-wikipedia-org-4107	545	99	b	b	NNP
en-wikipedia-org-4107	545	100	c	c	NNP
en-wikipedia-org-4107	545	101	d	d	NNP
en-wikipedia-org-4107	545	102	e	e	NNP
en-wikipedia-org-4107	545	103	f	f	NNP
en-wikipedia-org-4107	545	104	g	g	NNP
en-wikipedia-org-4107	545	105	h	h	NNP
en-wikipedia-org-4107	545	106	i	i	NN
en-wikipedia-org-4107	545	107	j	j	NNP
en-wikipedia-org-4107	545	108	k	k	NNP
en-wikipedia-org-4107	545	109	l	l	NNP
en-wikipedia-org-4107	545	110	m	m	NNP
en-wikipedia-org-4107	545	111	n	n	CC
en-wikipedia-org-4107	545	112	o	o	NNP
en-wikipedia-org-4107	545	113	p	p	NN
en-wikipedia-org-4107	545	114	q	q	NNP
en-wikipedia-org-4107	545	115	r	r	NNP
en-wikipedia-org-4107	545	116	s	s	NNP
en-wikipedia-org-4107	545	117	t	t	NNP
en-wikipedia-org-4107	545	118	u	u	NNP
en-wikipedia-org-4107	545	119	v	v	NNP
en-wikipedia-org-4107	545	120	w	w	NNP
en-wikipedia-org-4107	545	121	x	x	NNP
en-wikipedia-org-4107	545	122	y	y	NNP
en-wikipedia-org-4107	545	123	z	z	NNP
en-wikipedia-org-4107	545	124	aa	aa	NNP
en-wikipedia-org-4107	545	125	ab	ab	NNP
en-wikipedia-org-4107	545	126	ac	ac	NNP
en-wikipedia-org-4107	545	127	ad	ad	NN
en-wikipedia-org-4107	545	128	ae	ae	NNP
en-wikipedia-org-4107	545	129	af	af	NNP
en-wikipedia-org-4107	545	130	ag	ag	NNP
en-wikipedia-org-4107	545	131	ah	ah	UH
en-wikipedia-org-4107	545	132	ai	ai	VBP
en-wikipedia-org-4107	545	133	aj	aj	NNP
en-wikipedia-org-4107	545	134	ak	ak	NNP
en-wikipedia-org-4107	545	135	al	al	NNP
en-wikipedia-org-4107	545	136	am	be	VBP
en-wikipedia-org-4107	545	137	an	an	DT
en-wikipedia-org-4107	545	138	"	"	``
en-wikipedia-org-4107	545	139	Adderall	Adderall	NNP
en-wikipedia-org-4107	545	140	XR-	XR-	NNP
en-wikipedia-org-4107	545	141	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	545	142	sulfate	sulfate	NN
en-wikipedia-org-4107	545	143	,	,	,
en-wikipedia-org-4107	545	144	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	545	145	saccharate	saccharate	NN
en-wikipedia-org-4107	545	146	,	,	,
en-wikipedia-org-4107	545	147	amphetamine	amphetamine	VB
en-wikipedia-org-4107	545	148	sulfate	sulfate	NN
en-wikipedia-org-4107	545	149	and	and	CC
en-wikipedia-org-4107	545	150	amphetamine	amphetamine	VB
en-wikipedia-org-4107	545	151	aspartate	aspartate	NN
en-wikipedia-org-4107	545	152	capsule	capsule	NN
en-wikipedia-org-4107	545	153	,	,	,
en-wikipedia-org-4107	545	154	extended	extended	JJ
en-wikipedia-org-4107	545	155	release	release	NN
en-wikipedia-org-4107	545	156	"	"	''
en-wikipedia-org-4107	545	157	.	.	.
en-wikipedia-org-4107	546	1	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	546	2	.	.	.
en-wikipedia-org-4107	547	1	Shire	Shire	NNP
en-wikipedia-org-4107	547	2	US	US	NNP
en-wikipedia-org-4107	547	3	Inc.	Inc.	NNP
en-wikipedia-org-4107	547	4	17	17	CD
en-wikipedia-org-4107	547	5	July	July	NNP
en-wikipedia-org-4107	547	6	2019	2019	CD
en-wikipedia-org-4107	547	7	.	.	.
en-wikipedia-org-4107	548	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	548	2	22	22	CD
en-wikipedia-org-4107	548	3	December	December	NNP
en-wikipedia-org-4107	548	4	2019	2019	CD
en-wikipedia-org-4107	548	5	.	.	.
en-wikipedia-org-4107	549	1	^	^	NNP
en-wikipedia-org-4107	549	2	a	a	DT
en-wikipedia-org-4107	549	3	b	b	NN
en-wikipedia-org-4107	549	4	c	c	NNP
en-wikipedia-org-4107	549	5	d	d	NN
en-wikipedia-org-4107	549	6	Rasmussen	Rasmussen	NNP
en-wikipedia-org-4107	549	7	N	N	NNP
en-wikipedia-org-4107	549	8	(	(	-LRB-
en-wikipedia-org-4107	549	9	July	July	NNP
en-wikipedia-org-4107	549	10	2006	2006	CD
en-wikipedia-org-4107	549	11	)	)	-RRB-
en-wikipedia-org-4107	549	12	.	.	.
en-wikipedia-org-4107	550	1	"	"	``
en-wikipedia-org-4107	550	2	Making	make	VBG
en-wikipedia-org-4107	550	3	the	the	DT
en-wikipedia-org-4107	550	4	first	first	JJ
en-wikipedia-org-4107	550	5	anti	anti	JJ
en-wikipedia-org-4107	550	6	-	-	JJ
en-wikipedia-org-4107	550	7	depressant	depressant	JJ
en-wikipedia-org-4107	550	8	:	:	:
en-wikipedia-org-4107	550	9	amphetamine	amphetamine	VB
en-wikipedia-org-4107	550	10	in	in	IN
en-wikipedia-org-4107	550	11	American	american	JJ
en-wikipedia-org-4107	550	12	medicine	medicine	NN
en-wikipedia-org-4107	550	13	,	,	,
en-wikipedia-org-4107	550	14	1929–1950	1929–1950	CD
en-wikipedia-org-4107	550	15	"	"	''
en-wikipedia-org-4107	550	16	.	.	.
en-wikipedia-org-4107	551	1	Journal	Journal	NNP
en-wikipedia-org-4107	551	2	of	of	IN
en-wikipedia-org-4107	551	3	the	the	DT
en-wikipedia-org-4107	551	4	History	History	NNP
en-wikipedia-org-4107	551	5	of	of	IN
en-wikipedia-org-4107	551	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	551	7	and	and	CC
en-wikipedia-org-4107	551	8	Allied	Allied	NNP
en-wikipedia-org-4107	551	9	Sciences	Sciences	NNPS
en-wikipedia-org-4107	551	10	.	.	.
en-wikipedia-org-4107	552	1	61	61	CD
en-wikipedia-org-4107	552	2	(	(	-LRB-
en-wikipedia-org-4107	552	3	3	3	CD
en-wikipedia-org-4107	552	4	)	)	-RRB-
en-wikipedia-org-4107	552	5	:	:	:
en-wikipedia-org-4107	552	6	288–323	288–323	CD
en-wikipedia-org-4107	552	7	.	.	.
en-wikipedia-org-4107	553	1	doi:10.1093	doi:10.1093	NNP
en-wikipedia-org-4107	553	2	/	/	SYM
en-wikipedia-org-4107	553	3	jhmas	jhmas	NNP
en-wikipedia-org-4107	553	4	/	/	SYM
en-wikipedia-org-4107	553	5	jrj039	jrj039	NNP
en-wikipedia-org-4107	553	6	.	.	.
en-wikipedia-org-4107	554	1	PMID	PMID	NNP
en-wikipedia-org-4107	554	2	 	  	_SP
en-wikipedia-org-4107	554	3	16492800	16492800	CD
en-wikipedia-org-4107	554	4	.	.	.
en-wikipedia-org-4107	555	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	555	2	 	  	_SP
en-wikipedia-org-4107	555	3	24974454	24974454	CD
en-wikipedia-org-4107	555	4	.	.	.
en-wikipedia-org-4107	556	1	However	however	RB
en-wikipedia-org-4107	556	2	the	the	DT
en-wikipedia-org-4107	556	3	firm	firm	NN
en-wikipedia-org-4107	556	4	happened	happen	VBD
en-wikipedia-org-4107	556	5	to	to	TO
en-wikipedia-org-4107	556	6	discover	discover	VB
en-wikipedia-org-4107	556	7	the	the	DT
en-wikipedia-org-4107	556	8	drug	drug	NN
en-wikipedia-org-4107	556	9	,	,	,
en-wikipedia-org-4107	556	10	SKF	SKF	NNP
en-wikipedia-org-4107	556	11	first	first	RB
en-wikipedia-org-4107	556	12	packaged	package	VBD
en-wikipedia-org-4107	556	13	it	-PRON-	PRP
en-wikipedia-org-4107	556	14	as	as	IN
en-wikipedia-org-4107	556	15	an	an	DT
en-wikipedia-org-4107	556	16	inhaler	inhaler	NN
en-wikipedia-org-4107	556	17	so	so	IN
en-wikipedia-org-4107	556	18	as	as	IN
en-wikipedia-org-4107	556	19	to	to	TO
en-wikipedia-org-4107	556	20	exploit	exploit	VB
en-wikipedia-org-4107	556	21	the	the	DT
en-wikipedia-org-4107	556	22	base	base	NN
en-wikipedia-org-4107	556	23	's	's	POS
en-wikipedia-org-4107	556	24	volatility	volatility	NN
en-wikipedia-org-4107	556	25	and	and	CC
en-wikipedia-org-4107	556	26	,	,	,
en-wikipedia-org-4107	556	27	after	after	IN
en-wikipedia-org-4107	556	28	sponsoring	sponsor	VBG
en-wikipedia-org-4107	556	29	some	some	DT
en-wikipedia-org-4107	556	30	trials	trial	NNS
en-wikipedia-org-4107	556	31	by	by	IN
en-wikipedia-org-4107	556	32	East	East	NNP
en-wikipedia-org-4107	556	33	Coast	Coast	NNP
en-wikipedia-org-4107	556	34	otolaryngological	otolaryngological	JJ
en-wikipedia-org-4107	556	35	specialists	specialist	NNS
en-wikipedia-org-4107	556	36	,	,	,
en-wikipedia-org-4107	556	37	began	begin	VBD
en-wikipedia-org-4107	556	38	to	to	TO
en-wikipedia-org-4107	556	39	advertise	advertise	VB
en-wikipedia-org-4107	556	40	the	the	DT
en-wikipedia-org-4107	556	41	Benzedrine	Benzedrine	NNP
en-wikipedia-org-4107	556	42	Inhaler	Inhaler	NNP
en-wikipedia-org-4107	556	43	as	as	IN
en-wikipedia-org-4107	556	44	a	a	DT
en-wikipedia-org-4107	556	45	decongestant	decongestant	NN
en-wikipedia-org-4107	556	46	in	in	IN
en-wikipedia-org-4107	556	47	late	late	JJ
en-wikipedia-org-4107	556	48	1933	1933	CD
en-wikipedia-org-4107	556	49	.	.	.
en-wikipedia-org-4107	557	1	^	^	NNP
en-wikipedia-org-4107	557	2	a	a	DT
en-wikipedia-org-4107	557	3	b	b	NNP
en-wikipedia-org-4107	557	4	"	"	``
en-wikipedia-org-4107	557	5	Convention	Convention	NNP
en-wikipedia-org-4107	557	6	on	on	IN
en-wikipedia-org-4107	557	7	psychotropic	psychotropic	JJ
en-wikipedia-org-4107	557	8	substances	substance	NNS
en-wikipedia-org-4107	557	9	"	"	''
en-wikipedia-org-4107	557	10	.	.	.
en-wikipedia-org-4107	558	1	United	United	NNP
en-wikipedia-org-4107	558	2	Nations	Nations	NNP
en-wikipedia-org-4107	558	3	Treaty	Treaty	NNP
en-wikipedia-org-4107	558	4	Collection	Collection	NNP
en-wikipedia-org-4107	558	5	.	.	.
en-wikipedia-org-4107	559	1	United	United	NNP
en-wikipedia-org-4107	559	2	Nations	Nations	NNP
en-wikipedia-org-4107	559	3	.	.	.
en-wikipedia-org-4107	560	1	Archived	archived	JJ
en-wikipedia-org-4107	560	2	from	from	IN
en-wikipedia-org-4107	560	3	the	the	DT
en-wikipedia-org-4107	560	4	original	original	NN
en-wikipedia-org-4107	560	5	on	on	IN
en-wikipedia-org-4107	560	6	31	31	CD
en-wikipedia-org-4107	560	7	March	March	NNP
en-wikipedia-org-4107	560	8	2016	2016	CD
en-wikipedia-org-4107	560	9	.	.	.
en-wikipedia-org-4107	561	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	561	2	11	11	CD
en-wikipedia-org-4107	561	3	November	November	NNP
en-wikipedia-org-4107	561	4	2013	2013	CD
en-wikipedia-org-4107	561	5	.	.	.
en-wikipedia-org-4107	562	1	^	^	NNP
en-wikipedia-org-4107	562	2	a	a	DT
en-wikipedia-org-4107	562	3	b	b	NNP
en-wikipedia-org-4107	562	4	Wilens	Wilens	NNP
en-wikipedia-org-4107	562	5	TE	TE	NNP
en-wikipedia-org-4107	562	6	,	,	,
en-wikipedia-org-4107	562	7	Adler	Adler	NNP
en-wikipedia-org-4107	562	8	LA	LA	NNP
en-wikipedia-org-4107	562	9	,	,	,
en-wikipedia-org-4107	562	10	Adams	Adams	NNP
en-wikipedia-org-4107	562	11	J	J	NNP
en-wikipedia-org-4107	562	12	,	,	,
en-wikipedia-org-4107	562	13	Sgambati	Sgambati	NNP
en-wikipedia-org-4107	562	14	S	S	NNP
en-wikipedia-org-4107	562	15	,	,	,
en-wikipedia-org-4107	562	16	Rotrosen	Rotrosen	NNP
en-wikipedia-org-4107	562	17	J	J	NNP
en-wikipedia-org-4107	562	18	,	,	,
en-wikipedia-org-4107	562	19	Sawtelle	Sawtelle	NNP
en-wikipedia-org-4107	562	20	R	R	NNP
en-wikipedia-org-4107	562	21	,	,	,
en-wikipedia-org-4107	562	22	Utzinger	Utzinger	NNP
en-wikipedia-org-4107	562	23	L	L	NNP
en-wikipedia-org-4107	562	24	,	,	,
en-wikipedia-org-4107	562	25	Fusillo	Fusillo	NNP
en-wikipedia-org-4107	562	26	S	S	NNP
en-wikipedia-org-4107	562	27	(	(	-LRB-
en-wikipedia-org-4107	562	28	January	January	NNP
en-wikipedia-org-4107	562	29	2008	2008	CD
en-wikipedia-org-4107	562	30	)	)	-RRB-
en-wikipedia-org-4107	562	31	.	.	.
en-wikipedia-org-4107	563	1	"	"	``
en-wikipedia-org-4107	563	2	Misuse	misuse	NN
en-wikipedia-org-4107	563	3	and	and	CC
en-wikipedia-org-4107	563	4	diversion	diversion	NN
en-wikipedia-org-4107	563	5	of	of	IN
en-wikipedia-org-4107	563	6	stimulants	stimulant	NNS
en-wikipedia-org-4107	563	7	prescribed	prescribe	VBN
en-wikipedia-org-4107	563	8	for	for	IN
en-wikipedia-org-4107	563	9	ADHD	ADHD	NNP
en-wikipedia-org-4107	563	10	:	:	:
en-wikipedia-org-4107	563	11	a	a	DT
en-wikipedia-org-4107	563	12	systematic	systematic	JJ
en-wikipedia-org-4107	563	13	review	review	NN
en-wikipedia-org-4107	563	14	of	of	IN
en-wikipedia-org-4107	563	15	the	the	DT
en-wikipedia-org-4107	563	16	literature	literature	NN
en-wikipedia-org-4107	563	17	"	"	''
en-wikipedia-org-4107	563	18	.	.	.
en-wikipedia-org-4107	564	1	Journal	Journal	NNP
en-wikipedia-org-4107	564	2	of	of	IN
en-wikipedia-org-4107	564	3	the	the	DT
en-wikipedia-org-4107	564	4	American	American	NNP
en-wikipedia-org-4107	564	5	Academy	Academy	NNP
en-wikipedia-org-4107	564	6	of	of	IN
en-wikipedia-org-4107	564	7	Child	Child	NNP
en-wikipedia-org-4107	564	8	&	&	CC
en-wikipedia-org-4107	564	9	Adolescent	Adolescent	NNP
en-wikipedia-org-4107	564	10	Psychiatry	Psychiatry	NNP
en-wikipedia-org-4107	564	11	.	.	.
en-wikipedia-org-4107	565	1	47	47	CD
en-wikipedia-org-4107	565	2	(	(	-LRB-
en-wikipedia-org-4107	565	3	1	1	CD
en-wikipedia-org-4107	565	4	)	)	-RRB-
en-wikipedia-org-4107	565	5	:	:	:
en-wikipedia-org-4107	565	6	21–31	21–31	CD
en-wikipedia-org-4107	565	7	.	.	.
en-wikipedia-org-4107	566	1	doi:10.1097	doi:10.1097	NNP
en-wikipedia-org-4107	566	2	/	/	SYM
en-wikipedia-org-4107	566	3	chi.0b013e31815a56f1	chi.0b013e31815a56f1	NNP
en-wikipedia-org-4107	566	4	.	.	.
en-wikipedia-org-4107	567	1	PMID	PMID	NNP
en-wikipedia-org-4107	567	2	 	  	_SP
en-wikipedia-org-4107	567	3	18174822	18174822	CD
en-wikipedia-org-4107	567	4	.	.	.
en-wikipedia-org-4107	568	1	Stimulant	stimulant	JJ
en-wikipedia-org-4107	568	2	misuse	misuse	NN
en-wikipedia-org-4107	568	3	appears	appear	VBZ
en-wikipedia-org-4107	568	4	to	to	TO
en-wikipedia-org-4107	568	5	occur	occur	VB
en-wikipedia-org-4107	568	6	both	both	DT
en-wikipedia-org-4107	568	7	for	for	IN
en-wikipedia-org-4107	568	8	performance	performance	NN
en-wikipedia-org-4107	568	9	enhancement	enhancement	NN
en-wikipedia-org-4107	568	10	and	and	CC
en-wikipedia-org-4107	568	11	their	-PRON-	PRP$
en-wikipedia-org-4107	568	12	euphorogenic	euphorogenic	JJ
en-wikipedia-org-4107	568	13	effects	effect	NNS
en-wikipedia-org-4107	568	14	,	,	,
en-wikipedia-org-4107	568	15	the	the	DT
en-wikipedia-org-4107	568	16	latter	latter	JJ
en-wikipedia-org-4107	568	17	being	be	VBG
en-wikipedia-org-4107	568	18	related	relate	VBN
en-wikipedia-org-4107	568	19	to	to	IN
en-wikipedia-org-4107	568	20	the	the	DT
en-wikipedia-org-4107	568	21	intrinsic	intrinsic	JJ
en-wikipedia-org-4107	568	22	properties	property	NNS
en-wikipedia-org-4107	568	23	of	of	IN
en-wikipedia-org-4107	568	24	the	the	DT
en-wikipedia-org-4107	568	25	stimulants	stimulant	NNS
en-wikipedia-org-4107	568	26	(	(	-LRB-
en-wikipedia-org-4107	568	27	e.g.	e.g.	RB
en-wikipedia-org-4107	568	28	,	,	,
en-wikipedia-org-4107	568	29	IR	IR	NNP
en-wikipedia-org-4107	568	30	versus	versus	IN
en-wikipedia-org-4107	568	31	ER	ER	NNP
en-wikipedia-org-4107	568	32	profile	profile	NN
en-wikipedia-org-4107	568	33	)	)	-RRB-
en-wikipedia-org-4107	568	34	 	  	_SP
en-wikipedia-org-4107	568	35	...	...	:
en-wikipedia-org-4107	569	1	Although	although	IN
en-wikipedia-org-4107	569	2	useful	useful	JJ
en-wikipedia-org-4107	569	3	in	in	IN
en-wikipedia-org-4107	569	4	the	the	DT
en-wikipedia-org-4107	569	5	treatment	treatment	NN
en-wikipedia-org-4107	569	6	of	of	IN
en-wikipedia-org-4107	569	7	ADHD	ADHD	NNP
en-wikipedia-org-4107	569	8	,	,	,
en-wikipedia-org-4107	569	9	stimulants	stimulant	NNS
en-wikipedia-org-4107	569	10	are	be	VBP
en-wikipedia-org-4107	569	11	controlled	control	VBN
en-wikipedia-org-4107	569	12	II	II	NNP
en-wikipedia-org-4107	569	13	substances	substance	NNS
en-wikipedia-org-4107	569	14	with	with	IN
en-wikipedia-org-4107	569	15	a	a	DT
en-wikipedia-org-4107	569	16	history	history	NN
en-wikipedia-org-4107	569	17	of	of	IN
en-wikipedia-org-4107	569	18	preclinical	preclinical	JJ
en-wikipedia-org-4107	569	19	and	and	CC
en-wikipedia-org-4107	569	20	human	human	JJ
en-wikipedia-org-4107	569	21	studies	study	NNS
en-wikipedia-org-4107	569	22	showing	show	VBG
en-wikipedia-org-4107	569	23	potential	potential	JJ
en-wikipedia-org-4107	569	24	abuse	abuse	NN
en-wikipedia-org-4107	569	25	liability	liability	NN
en-wikipedia-org-4107	569	26	.	.	.
en-wikipedia-org-4107	570	1	^	^	NNP
en-wikipedia-org-4107	570	2	a	a	DT
en-wikipedia-org-4107	570	3	b	b	NNP
en-wikipedia-org-4107	570	4	c	c	NN
en-wikipedia-org-4107	570	5	Montgomery	Montgomery	NNP
en-wikipedia-org-4107	570	6	KA	KA	NNP
en-wikipedia-org-4107	570	7	(	(	-LRB-
en-wikipedia-org-4107	570	8	June	June	NNP
en-wikipedia-org-4107	570	9	2008	2008	CD
en-wikipedia-org-4107	570	10	)	)	-RRB-
en-wikipedia-org-4107	570	11	.	.	.
en-wikipedia-org-4107	571	1	"	"	``
en-wikipedia-org-4107	571	2	Sexual	sexual	JJ
en-wikipedia-org-4107	571	3	desire	desire	NN
en-wikipedia-org-4107	571	4	disorders	disorder	NNS
en-wikipedia-org-4107	571	5	"	"	''
en-wikipedia-org-4107	571	6	.	.	.
en-wikipedia-org-4107	572	1	Psychiatry	psychiatry	NN
en-wikipedia-org-4107	572	2	.	.	.
en-wikipedia-org-4107	573	1	5	5	CD
en-wikipedia-org-4107	573	2	(	(	-LRB-
en-wikipedia-org-4107	573	3	6	6	CD
en-wikipedia-org-4107	573	4	)	)	-RRB-
en-wikipedia-org-4107	573	5	:	:	:
en-wikipedia-org-4107	573	6	50–55	50–55	CD
en-wikipedia-org-4107	573	7	.	.	.
en-wikipedia-org-4107	574	1	PMC	PMC	NNP
en-wikipedia-org-4107	574	2	 	  	_SP
en-wikipedia-org-4107	574	3	2695750	2695750	CD
en-wikipedia-org-4107	574	4	.	.	.
en-wikipedia-org-4107	575	1	PMID	PMID	NNP
en-wikipedia-org-4107	575	2	 	  	_SP
en-wikipedia-org-4107	575	3	19727285	19727285	CD
en-wikipedia-org-4107	575	4	.	.	.
en-wikipedia-org-4107	576	1	^	^	FW
en-wikipedia-org-4107	576	2	"	"	``
en-wikipedia-org-4107	576	3	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	576	4	"	"	''
en-wikipedia-org-4107	576	5	.	.	.
en-wikipedia-org-4107	577	1	Medical	Medical	NNP
en-wikipedia-org-4107	577	2	Subject	Subject	NNP
en-wikipedia-org-4107	577	3	Headings	Headings	NNPS
en-wikipedia-org-4107	577	4	.	.	.
en-wikipedia-org-4107	578	1	United	United	NNP
en-wikipedia-org-4107	578	2	States	States	NNP
en-wikipedia-org-4107	578	3	National	National	NNP
en-wikipedia-org-4107	578	4	Library	Library	NNP
en-wikipedia-org-4107	578	5	of	of	IN
en-wikipedia-org-4107	578	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	578	7	.	.	.
en-wikipedia-org-4107	579	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	579	2	16	16	CD
en-wikipedia-org-4107	579	3	December	December	NNP
en-wikipedia-org-4107	579	4	2013	2013	CD
en-wikipedia-org-4107	579	5	.	.	.
en-wikipedia-org-4107	580	1	^	^	FW
en-wikipedia-org-4107	580	2	"	"	``
en-wikipedia-org-4107	580	3	Guidelines	guideline	NNS
en-wikipedia-org-4107	580	4	on	on	IN
en-wikipedia-org-4107	580	5	the	the	DT
en-wikipedia-org-4107	580	6	Use	Use	NNP
en-wikipedia-org-4107	580	7	of	of	IN
en-wikipedia-org-4107	580	8	International	International	NNP
en-wikipedia-org-4107	580	9	Nonproprietary	Nonproprietary	NNP
en-wikipedia-org-4107	580	10	Names	Names	NNPS
en-wikipedia-org-4107	580	11	(	(	-LRB-
en-wikipedia-org-4107	580	12	INNS	INNS	NNP
en-wikipedia-org-4107	580	13	)	)	-RRB-
en-wikipedia-org-4107	580	14	for	for	IN
en-wikipedia-org-4107	580	15	Pharmaceutical	Pharmaceutical	NNP
en-wikipedia-org-4107	580	16	Substances	Substances	NNP
en-wikipedia-org-4107	580	17	"	"	''
en-wikipedia-org-4107	580	18	.	.	.
en-wikipedia-org-4107	581	1	World	World	NNP
en-wikipedia-org-4107	581	2	Health	Health	NNP
en-wikipedia-org-4107	581	3	Organization	Organization	NNP
en-wikipedia-org-4107	581	4	.	.	.
en-wikipedia-org-4107	582	1	1997	1997	CD
en-wikipedia-org-4107	582	2	.	.	.
en-wikipedia-org-4107	583	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	583	2	1	1	CD
en-wikipedia-org-4107	583	3	December	December	NNP
en-wikipedia-org-4107	583	4	2014	2014	CD
en-wikipedia-org-4107	583	5	.	.	.
en-wikipedia-org-4107	584	1	In	in	IN
en-wikipedia-org-4107	584	2	principle	principle	NN
en-wikipedia-org-4107	584	3	,	,	,
en-wikipedia-org-4107	584	4	INNs	inn	NNS
en-wikipedia-org-4107	584	5	are	be	VBP
en-wikipedia-org-4107	584	6	selected	select	VBN
en-wikipedia-org-4107	584	7	only	only	RB
en-wikipedia-org-4107	584	8	for	for	IN
en-wikipedia-org-4107	584	9	the	the	DT
en-wikipedia-org-4107	584	10	active	active	JJ
en-wikipedia-org-4107	584	11	part	part	NN
en-wikipedia-org-4107	584	12	of	of	IN
en-wikipedia-org-4107	584	13	the	the	DT
en-wikipedia-org-4107	584	14	molecule	molecule	NN
en-wikipedia-org-4107	584	15	which	which	WDT
en-wikipedia-org-4107	584	16	is	be	VBZ
en-wikipedia-org-4107	584	17	usually	usually	RB
en-wikipedia-org-4107	584	18	the	the	DT
en-wikipedia-org-4107	584	19	base	base	NN
en-wikipedia-org-4107	584	20	,	,	,
en-wikipedia-org-4107	584	21	acid	acid	NN
en-wikipedia-org-4107	584	22	or	or	CC
en-wikipedia-org-4107	584	23	alcohol	alcohol	NN
en-wikipedia-org-4107	584	24	.	.	.
en-wikipedia-org-4107	585	1	In	in	IN
en-wikipedia-org-4107	585	2	some	some	DT
en-wikipedia-org-4107	585	3	cases	case	NNS
en-wikipedia-org-4107	585	4	,	,	,
en-wikipedia-org-4107	585	5	however	however	RB
en-wikipedia-org-4107	585	6	,	,	,
en-wikipedia-org-4107	585	7	the	the	DT
en-wikipedia-org-4107	585	8	active	active	JJ
en-wikipedia-org-4107	585	9	molecules	molecule	NNS
en-wikipedia-org-4107	585	10	need	need	VBP
en-wikipedia-org-4107	585	11	to	to	TO
en-wikipedia-org-4107	585	12	be	be	VB
en-wikipedia-org-4107	585	13	expanded	expand	VBN
en-wikipedia-org-4107	585	14	for	for	IN
en-wikipedia-org-4107	585	15	various	various	JJ
en-wikipedia-org-4107	585	16	reasons	reason	NNS
en-wikipedia-org-4107	585	17	,	,	,
en-wikipedia-org-4107	585	18	such	such	JJ
en-wikipedia-org-4107	585	19	as	as	IN
en-wikipedia-org-4107	585	20	formulation	formulation	NN
en-wikipedia-org-4107	585	21	purposes	purpose	NNS
en-wikipedia-org-4107	585	22	,	,	,
en-wikipedia-org-4107	585	23	bioavailability	bioavailability	NN
en-wikipedia-org-4107	585	24	or	or	CC
en-wikipedia-org-4107	585	25	absorption	absorption	NN
en-wikipedia-org-4107	585	26	rate	rate	NN
en-wikipedia-org-4107	585	27	.	.	.
en-wikipedia-org-4107	586	1	In	in	IN
en-wikipedia-org-4107	586	2	1975	1975	CD
en-wikipedia-org-4107	586	3	the	the	DT
en-wikipedia-org-4107	586	4	experts	expert	NNS
en-wikipedia-org-4107	586	5	designated	designate	VBN
en-wikipedia-org-4107	586	6	for	for	IN
en-wikipedia-org-4107	586	7	the	the	DT
en-wikipedia-org-4107	586	8	selection	selection	NN
en-wikipedia-org-4107	586	9	of	of	IN
en-wikipedia-org-4107	586	10	INN	INN	NNP
en-wikipedia-org-4107	586	11	decided	decide	VBD
en-wikipedia-org-4107	586	12	to	to	TO
en-wikipedia-org-4107	586	13	adopt	adopt	VB
en-wikipedia-org-4107	586	14	a	a	DT
en-wikipedia-org-4107	586	15	new	new	JJ
en-wikipedia-org-4107	586	16	policy	policy	NN
en-wikipedia-org-4107	586	17	for	for	IN
en-wikipedia-org-4107	586	18	naming	name	VBG
en-wikipedia-org-4107	586	19	such	such	JJ
en-wikipedia-org-4107	586	20	molecules	molecule	NNS
en-wikipedia-org-4107	586	21	.	.	.
en-wikipedia-org-4107	587	1	In	in	IN
en-wikipedia-org-4107	587	2	future	future	NN
en-wikipedia-org-4107	587	3	,	,	,
en-wikipedia-org-4107	587	4	names	name	NNS
en-wikipedia-org-4107	587	5	for	for	IN
en-wikipedia-org-4107	587	6	different	different	JJ
en-wikipedia-org-4107	587	7	salts	salt	NNS
en-wikipedia-org-4107	587	8	or	or	CC
en-wikipedia-org-4107	587	9	esters	ester	NNS
en-wikipedia-org-4107	587	10	of	of	IN
en-wikipedia-org-4107	587	11	the	the	DT
en-wikipedia-org-4107	587	12	same	same	JJ
en-wikipedia-org-4107	587	13	active	active	JJ
en-wikipedia-org-4107	587	14	substance	substance	NN
en-wikipedia-org-4107	587	15	should	should	MD
en-wikipedia-org-4107	587	16	differ	differ	VB
en-wikipedia-org-4107	587	17	only	only	RB
en-wikipedia-org-4107	587	18	with	with	IN
en-wikipedia-org-4107	587	19	regard	regard	NN
en-wikipedia-org-4107	587	20	to	to	IN
en-wikipedia-org-4107	587	21	the	the	DT
en-wikipedia-org-4107	587	22	inactive	inactive	JJ
en-wikipedia-org-4107	587	23	moiety	moiety	NN
en-wikipedia-org-4107	587	24	of	of	IN
en-wikipedia-org-4107	587	25	the	the	DT
en-wikipedia-org-4107	587	26	molecule	molecule	NN
en-wikipedia-org-4107	587	27	.	.	.
en-wikipedia-org-4107	588	1	...	...	NFP
en-wikipedia-org-4107	589	1	The	the	DT
en-wikipedia-org-4107	589	2	latter	latter	JJ
en-wikipedia-org-4107	589	3	are	be	VBP
en-wikipedia-org-4107	589	4	called	call	VBN
en-wikipedia-org-4107	589	5	modified	modify	VBN
en-wikipedia-org-4107	589	6	INNs	inn	NNS
en-wikipedia-org-4107	589	7	(	(	-LRB-
en-wikipedia-org-4107	589	8	INNMs	INNMs	NNP
en-wikipedia-org-4107	589	9	)	)	-RRB-
en-wikipedia-org-4107	589	10	.	.	.
en-wikipedia-org-4107	590	1	^	^	NNP
en-wikipedia-org-4107	590	2	a	a	DT
en-wikipedia-org-4107	590	3	b	b	NNP
en-wikipedia-org-4107	590	4	c	c	NNP
en-wikipedia-org-4107	590	5	d	d	NNP
en-wikipedia-org-4107	590	6	e	e	NNP
en-wikipedia-org-4107	590	7	f	f	NNP
en-wikipedia-org-4107	590	8	g	g	NNP
en-wikipedia-org-4107	590	9	h	h	NNP
en-wikipedia-org-4107	590	10	i	i	NN
en-wikipedia-org-4107	590	11	"	"	``
en-wikipedia-org-4107	590	12	Evekeo-	evekeo-	NN
en-wikipedia-org-4107	590	13	amphetamine	amphetamine	VBP
en-wikipedia-org-4107	590	14	sulfate	sulfate	NN
en-wikipedia-org-4107	590	15	tablet	tablet	NN
en-wikipedia-org-4107	590	16	"	"	''
en-wikipedia-org-4107	590	17	.	.	.
en-wikipedia-org-4107	591	1	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	591	2	.	.	.
en-wikipedia-org-4107	592	1	Arbor	Arbor	NNP
en-wikipedia-org-4107	592	2	Pharmaceuticals	Pharmaceuticals	NNPS
en-wikipedia-org-4107	592	3	,	,	,
en-wikipedia-org-4107	592	4	LLC	LLC	NNP
en-wikipedia-org-4107	592	5	.	.	.
en-wikipedia-org-4107	593	1	14	14	CD
en-wikipedia-org-4107	593	2	August	August	NNP
en-wikipedia-org-4107	593	3	2019	2019	CD
en-wikipedia-org-4107	593	4	.	.	.
en-wikipedia-org-4107	594	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	594	2	22	22	CD
en-wikipedia-org-4107	594	3	December	December	NNP
en-wikipedia-org-4107	594	4	2019	2019	CD
en-wikipedia-org-4107	594	5	.	.	.
en-wikipedia-org-4107	595	1	^	^	NNP
en-wikipedia-org-4107	595	2	a	a	DT
en-wikipedia-org-4107	595	3	b	b	NNP
en-wikipedia-org-4107	595	4	c	c	NNP
en-wikipedia-org-4107	595	5	d	d	NNP
en-wikipedia-org-4107	595	6	e	e	NNP
en-wikipedia-org-4107	595	7	f	f	NNP
en-wikipedia-org-4107	595	8	g	g	NNP
en-wikipedia-org-4107	595	9	h	h	NNP
en-wikipedia-org-4107	595	10	"	"	``
en-wikipedia-org-4107	595	11	National	National	NNP
en-wikipedia-org-4107	595	12	Drug	Drug	NNP
en-wikipedia-org-4107	595	13	Code	Code	NNP
en-wikipedia-org-4107	595	14	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	595	15	Search	Search	NNP
en-wikipedia-org-4107	595	16	Results	Results	NNPS
en-wikipedia-org-4107	595	17	"	"	''
en-wikipedia-org-4107	595	18	.	.	.
en-wikipedia-org-4107	596	1	National	National	NNP
en-wikipedia-org-4107	596	2	Drug	Drug	NNP
en-wikipedia-org-4107	596	3	Code	Code	NNP
en-wikipedia-org-4107	596	4	Directory	Directory	NNP
en-wikipedia-org-4107	596	5	.	.	.
en-wikipedia-org-4107	597	1	United	United	NNP
en-wikipedia-org-4107	597	2	States	States	NNP
en-wikipedia-org-4107	597	3	Food	Food	NNP
en-wikipedia-org-4107	597	4	and	and	CC
en-wikipedia-org-4107	597	5	Drug	Drug	NNP
en-wikipedia-org-4107	597	6	Administration	Administration	NNP
en-wikipedia-org-4107	597	7	.	.	.
en-wikipedia-org-4107	598	1	Archived	archived	JJ
en-wikipedia-org-4107	598	2	from	from	IN
en-wikipedia-org-4107	598	3	the	the	DT
en-wikipedia-org-4107	598	4	original	original	NN
en-wikipedia-org-4107	598	5	on	on	IN
en-wikipedia-org-4107	598	6	16	16	CD
en-wikipedia-org-4107	598	7	December	December	NNP
en-wikipedia-org-4107	598	8	2013	2013	CD
en-wikipedia-org-4107	598	9	.	.	.
en-wikipedia-org-4107	599	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	599	2	16	16	CD
en-wikipedia-org-4107	599	3	December	December	NNP
en-wikipedia-org-4107	599	4	2013	2013	CD
en-wikipedia-org-4107	599	5	.	.	.
en-wikipedia-org-4107	600	1	^	^	NNP
en-wikipedia-org-4107	600	2	a	a	DT
en-wikipedia-org-4107	600	3	b	b	NNP
en-wikipedia-org-4107	600	4	c	c	NNP
en-wikipedia-org-4107	600	5	d	d	NNP
en-wikipedia-org-4107	600	6	e	e	NNP
en-wikipedia-org-4107	600	7	f	f	NNP
en-wikipedia-org-4107	600	8	g	g	NNP
en-wikipedia-org-4107	600	9	h	h	NNP
en-wikipedia-org-4107	600	10	i	i	NN
en-wikipedia-org-4107	600	11	j	j	NNP
en-wikipedia-org-4107	600	12	k	k	NNP
en-wikipedia-org-4107	600	13	l	l	NNP
en-wikipedia-org-4107	600	14	m	m	NNP
en-wikipedia-org-4107	600	15	n	n	CC
en-wikipedia-org-4107	600	16	o	o	NNP
en-wikipedia-org-4107	600	17	p	p	NN
en-wikipedia-org-4107	600	18	q	q	NNP
en-wikipedia-org-4107	600	19	r	r	NNP
en-wikipedia-org-4107	600	20	s	s	NNP
en-wikipedia-org-4107	600	21	t	t	NNP
en-wikipedia-org-4107	600	22	u	u	NNP
en-wikipedia-org-4107	600	23	v	v	NNP
en-wikipedia-org-4107	600	24	w	w	NNP
en-wikipedia-org-4107	600	25	x	x	NNP
en-wikipedia-org-4107	600	26	y	y	NNP
en-wikipedia-org-4107	600	27	z	z	NNP
en-wikipedia-org-4107	600	28	aa	aa	NNP
en-wikipedia-org-4107	600	29	ab	ab	NNP
en-wikipedia-org-4107	600	30	ac	ac	NNP
en-wikipedia-org-4107	600	31	ad	ad	NN
en-wikipedia-org-4107	600	32	Miller	Miller	NNP
en-wikipedia-org-4107	600	33	GM	GM	NNP
en-wikipedia-org-4107	600	34	(	(	-LRB-
en-wikipedia-org-4107	600	35	January	January	NNP
en-wikipedia-org-4107	600	36	2011	2011	CD
en-wikipedia-org-4107	600	37	)	)	-RRB-
en-wikipedia-org-4107	600	38	.	.	.
en-wikipedia-org-4107	601	1	"	"	``
en-wikipedia-org-4107	601	2	The	the	DT
en-wikipedia-org-4107	601	3	emerging	emerge	VBG
en-wikipedia-org-4107	601	4	role	role	NN
en-wikipedia-org-4107	601	5	of	of	IN
en-wikipedia-org-4107	601	6	trace	trace	NN
en-wikipedia-org-4107	601	7	amine	amine	NN
en-wikipedia-org-4107	601	8	-	-	HYPH
en-wikipedia-org-4107	601	9	associated	associate	VBN
en-wikipedia-org-4107	601	10	receptor	receptor	NNP
en-wikipedia-org-4107	601	11	1	1	CD
en-wikipedia-org-4107	601	12	in	in	IN
en-wikipedia-org-4107	601	13	the	the	DT
en-wikipedia-org-4107	601	14	functional	functional	JJ
en-wikipedia-org-4107	601	15	regulation	regulation	NN
en-wikipedia-org-4107	601	16	of	of	IN
en-wikipedia-org-4107	601	17	monoamine	monoamine	NN
en-wikipedia-org-4107	601	18	transporters	transporter	NNS
en-wikipedia-org-4107	601	19	and	and	CC
en-wikipedia-org-4107	601	20	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	601	21	activity	activity	NN
en-wikipedia-org-4107	601	22	"	"	''
en-wikipedia-org-4107	601	23	.	.	.
en-wikipedia-org-4107	602	1	Journal	Journal	NNP
en-wikipedia-org-4107	602	2	of	of	IN
en-wikipedia-org-4107	602	3	Neurochemistry	Neurochemistry	NNP
en-wikipedia-org-4107	602	4	.	.	.
en-wikipedia-org-4107	603	1	116	116	CD
en-wikipedia-org-4107	603	2	(	(	-LRB-
en-wikipedia-org-4107	603	3	2	2	CD
en-wikipedia-org-4107	603	4	)	)	-RRB-
en-wikipedia-org-4107	603	5	:	:	:
en-wikipedia-org-4107	603	6	164–176	164–176	CD
en-wikipedia-org-4107	603	7	.	.	.
en-wikipedia-org-4107	604	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-4107	604	2	/	/	SYM
en-wikipedia-org-4107	604	3	j.1471	j.1471	NNP
en-wikipedia-org-4107	604	4	-	-	HYPH
en-wikipedia-org-4107	604	5	4159.2010.07109.x	4159.2010.07109.x	CD
en-wikipedia-org-4107	604	6	.	.	.
en-wikipedia-org-4107	605	1	PMC	PMC	NNP
en-wikipedia-org-4107	605	2	 	  	_SP
en-wikipedia-org-4107	605	3	3005101	3005101	CD
en-wikipedia-org-4107	605	4	.	.	.
en-wikipedia-org-4107	606	1	PMID	PMID	NNP
en-wikipedia-org-4107	606	2	 	  	_SP
en-wikipedia-org-4107	606	3	21073468	21073468	CD
en-wikipedia-org-4107	606	4	.	.	.
en-wikipedia-org-4107	607	1	^	^	NNP
en-wikipedia-org-4107	607	2	a	a	DT
en-wikipedia-org-4107	607	3	b	b	NNP
en-wikipedia-org-4107	607	4	c	c	NN
en-wikipedia-org-4107	607	5	d	d	NN
en-wikipedia-org-4107	607	6	e	e	NN
en-wikipedia-org-4107	607	7	Grandy	Grandy	NNP
en-wikipedia-org-4107	607	8	DK	DK	NNP
en-wikipedia-org-4107	607	9	,	,	,
en-wikipedia-org-4107	607	10	Miller	Miller	NNP
en-wikipedia-org-4107	607	11	GM	GM	NNP
en-wikipedia-org-4107	607	12	,	,	,
en-wikipedia-org-4107	607	13	Li	Li	NNP
en-wikipedia-org-4107	607	14	JX	JX	NNP
en-wikipedia-org-4107	607	15	(	(	-LRB-
en-wikipedia-org-4107	607	16	February	February	NNP
en-wikipedia-org-4107	607	17	2016	2016	CD
en-wikipedia-org-4107	607	18	)	)	-RRB-
en-wikipedia-org-4107	607	19	.	.	.
en-wikipedia-org-4107	608	1	"	"	``
en-wikipedia-org-4107	608	2	"	"	``
en-wikipedia-org-4107	608	3	TAARgeting	taargete	VBG
en-wikipedia-org-4107	608	4	Addiction"-The	Addiction"-The	NNP
en-wikipedia-org-4107	608	5	Alamo	Alamo	NNP
en-wikipedia-org-4107	608	6	Bears	bear	VBZ
en-wikipedia-org-4107	608	7	Witness	Witness	NNP
en-wikipedia-org-4107	608	8	to	to	IN
en-wikipedia-org-4107	608	9	Another	another	DT
en-wikipedia-org-4107	608	10	Revolution	Revolution	NNP
en-wikipedia-org-4107	608	11	:	:	:
en-wikipedia-org-4107	608	12	An	an	DT
en-wikipedia-org-4107	608	13	Overview	Overview	NNP
en-wikipedia-org-4107	608	14	of	of	IN
en-wikipedia-org-4107	608	15	the	the	DT
en-wikipedia-org-4107	608	16	Plenary	Plenary	NNP
en-wikipedia-org-4107	608	17	Symposium	Symposium	NNP
en-wikipedia-org-4107	608	18	of	of	IN
en-wikipedia-org-4107	608	19	the	the	DT
en-wikipedia-org-4107	608	20	2015	2015	CD
en-wikipedia-org-4107	608	21	Behavior	Behavior	NNP
en-wikipedia-org-4107	608	22	,	,	,
en-wikipedia-org-4107	608	23	Biology	Biology	NNP
en-wikipedia-org-4107	608	24	and	and	CC
en-wikipedia-org-4107	608	25	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	608	26	Conference	Conference	NNP
en-wikipedia-org-4107	608	27	"	"	''
en-wikipedia-org-4107	608	28	.	.	.
en-wikipedia-org-4107	609	1	Drug	Drug	NNP
en-wikipedia-org-4107	609	2	and	and	CC
en-wikipedia-org-4107	609	3	Alcohol	Alcohol	NNP
en-wikipedia-org-4107	609	4	Dependence	Dependence	NNP
en-wikipedia-org-4107	609	5	.	.	.
en-wikipedia-org-4107	610	1	159	159	CD
en-wikipedia-org-4107	610	2	:	:	:
en-wikipedia-org-4107	610	3	9–16	9–16	CD
en-wikipedia-org-4107	610	4	.	.	.
en-wikipedia-org-4107	611	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	611	2	/	/	SYM
en-wikipedia-org-4107	611	3	j.drugalcdep.2015.11.014	j.drugalcdep.2015.11.014	NNS
en-wikipedia-org-4107	611	4	.	.	.
en-wikipedia-org-4107	612	1	PMC	PMC	NNP
en-wikipedia-org-4107	612	2	 	  	_SP
en-wikipedia-org-4107	612	3	4724540	4724540	CD
en-wikipedia-org-4107	612	4	.	.	.
en-wikipedia-org-4107	613	1	PMID	PMID	NNP
en-wikipedia-org-4107	613	2	 	  	_SP
en-wikipedia-org-4107	613	3	26644139	26644139	CD
en-wikipedia-org-4107	613	4	.	.	.
en-wikipedia-org-4107	614	1	When	when	WRB
en-wikipedia-org-4107	614	2	considered	consider	VBN
en-wikipedia-org-4107	614	3	together	together	RB
en-wikipedia-org-4107	614	4	with	with	IN
en-wikipedia-org-4107	614	5	the	the	DT
en-wikipedia-org-4107	614	6	rapidly	rapidly	RB
en-wikipedia-org-4107	614	7	growing	grow	VBG
en-wikipedia-org-4107	614	8	literature	literature	NN
en-wikipedia-org-4107	614	9	in	in	IN
en-wikipedia-org-4107	614	10	the	the	DT
en-wikipedia-org-4107	614	11	field	field	NN
en-wikipedia-org-4107	614	12	a	a	DT
en-wikipedia-org-4107	614	13	compelling	compelling	JJ
en-wikipedia-org-4107	614	14	case	case	NN
en-wikipedia-org-4107	614	15	emerges	emerge	VBZ
en-wikipedia-org-4107	614	16	in	in	IN
en-wikipedia-org-4107	614	17	support	support	NN
en-wikipedia-org-4107	614	18	of	of	IN
en-wikipedia-org-4107	614	19	developing	develop	VBG
en-wikipedia-org-4107	614	20	TAAR1-selective	taar1-selective	JJ
en-wikipedia-org-4107	614	21	agonists	agonist	NNS
en-wikipedia-org-4107	614	22	as	as	IN
en-wikipedia-org-4107	614	23	medications	medication	NNS
en-wikipedia-org-4107	614	24	for	for	IN
en-wikipedia-org-4107	614	25	preventing	prevent	VBG
en-wikipedia-org-4107	614	26	relapse	relapse	NN
en-wikipedia-org-4107	614	27	to	to	IN
en-wikipedia-org-4107	614	28	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	614	29	abuse	abuse	NN
en-wikipedia-org-4107	614	30	.	.	.
en-wikipedia-org-4107	615	1	^	^	NNP
en-wikipedia-org-4107	615	2	a	a	DT
en-wikipedia-org-4107	615	3	b	b	NNP
en-wikipedia-org-4107	615	4	c	c	NNP
en-wikipedia-org-4107	615	5	d	d	NNP
en-wikipedia-org-4107	615	6	e	e	NNP
en-wikipedia-org-4107	615	7	f	f	NNP
en-wikipedia-org-4107	615	8	g	g	NNP
en-wikipedia-org-4107	615	9	h	h	NNP
en-wikipedia-org-4107	615	10	i	i	NN
en-wikipedia-org-4107	615	11	j	j	NNP
en-wikipedia-org-4107	615	12	k	k	NNP
en-wikipedia-org-4107	615	13	l	l	NNP
en-wikipedia-org-4107	615	14	m	m	NNP
en-wikipedia-org-4107	615	15	n	n	CC
en-wikipedia-org-4107	615	16	o	o	NNP
en-wikipedia-org-4107	615	17	p	p	NN
en-wikipedia-org-4107	615	18	q	q	NNP
en-wikipedia-org-4107	615	19	r	r	NNP
en-wikipedia-org-4107	615	20	s	s	NNP
en-wikipedia-org-4107	615	21	t	t	NNP
en-wikipedia-org-4107	615	22	u	u	NNP
en-wikipedia-org-4107	615	23	v	v	NNP
en-wikipedia-org-4107	615	24	w	w	NN
en-wikipedia-org-4107	615	25	Westfall	Westfall	NNP
en-wikipedia-org-4107	615	26	DP	DP	NNP
en-wikipedia-org-4107	615	27	,	,	,
en-wikipedia-org-4107	615	28	Westfall	Westfall	NNP
en-wikipedia-org-4107	615	29	TC	TC	NNP
en-wikipedia-org-4107	615	30	(	(	-LRB-
en-wikipedia-org-4107	615	31	2010	2010	CD
en-wikipedia-org-4107	615	32	)	)	-RRB-
en-wikipedia-org-4107	615	33	.	.	.
en-wikipedia-org-4107	616	1	"	"	``
en-wikipedia-org-4107	616	2	Miscellaneous	Miscellaneous	NNP
en-wikipedia-org-4107	616	3	Sympathomimetic	Sympathomimetic	NNP
en-wikipedia-org-4107	616	4	Agonists	Agonists	NNPS
en-wikipedia-org-4107	616	5	"	"	''
en-wikipedia-org-4107	616	6	.	.	.
en-wikipedia-org-4107	617	1	In	in	IN
en-wikipedia-org-4107	617	2	Brunton	Brunton	NNP
en-wikipedia-org-4107	617	3	LL	LL	NNP
en-wikipedia-org-4107	617	4	,	,	,
en-wikipedia-org-4107	617	5	Chabner	Chabner	NNP
en-wikipedia-org-4107	617	6	BA	BA	NNP
en-wikipedia-org-4107	617	7	,	,	,
en-wikipedia-org-4107	617	8	Knollmann	Knollmann	NNP
en-wikipedia-org-4107	617	9	BC	BC	NNP
en-wikipedia-org-4107	617	10	(	(	-LRB-
en-wikipedia-org-4107	617	11	eds	eds	NNP
en-wikipedia-org-4107	617	12	.	.	.
en-wikipedia-org-4107	617	13	)	)	-RRB-
en-wikipedia-org-4107	617	14	.	.	.
en-wikipedia-org-4107	618	1	Goodman	Goodman	NNP
en-wikipedia-org-4107	618	2	&	&	CC
en-wikipedia-org-4107	618	3	Gilman	Gilman	NNP
en-wikipedia-org-4107	618	4	's	's	POS
en-wikipedia-org-4107	618	5	Pharmacological	Pharmacological	NNP
en-wikipedia-org-4107	618	6	Basis	Basis	NNP
en-wikipedia-org-4107	618	7	of	of	IN
en-wikipedia-org-4107	618	8	Therapeutics	Therapeutics	NNP
en-wikipedia-org-4107	618	9	(	(	-LRB-
en-wikipedia-org-4107	618	10	12th	12th	NNP
en-wikipedia-org-4107	618	11	ed	ed	NNP
en-wikipedia-org-4107	618	12	.	.	.
en-wikipedia-org-4107	618	13	)	)	-RRB-
en-wikipedia-org-4107	618	14	.	.	.
en-wikipedia-org-4107	619	1	New	New	NNP
en-wikipedia-org-4107	619	2	York	York	NNP
en-wikipedia-org-4107	619	3	,	,	,
en-wikipedia-org-4107	619	4	USA	USA	NNP
en-wikipedia-org-4107	619	5	:	:	:
en-wikipedia-org-4107	619	6	McGraw	McGraw	NNP
en-wikipedia-org-4107	619	7	-	-	HYPH
en-wikipedia-org-4107	619	8	Hill	Hill	NNP
en-wikipedia-org-4107	619	9	.	.	.
en-wikipedia-org-4107	620	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	620	2	 	  	_SP
en-wikipedia-org-4107	620	3	9780071624428	9780071624428	CD
en-wikipedia-org-4107	620	4	.	.	.
en-wikipedia-org-4107	621	1	^	^	NNP
en-wikipedia-org-4107	621	2	a	a	DT
en-wikipedia-org-4107	621	3	b	b	NNP
en-wikipedia-org-4107	621	4	c	c	NN
en-wikipedia-org-4107	621	5	d	d	NN
en-wikipedia-org-4107	621	6	e	e	NN
en-wikipedia-org-4107	621	7	Shoptaw	Shoptaw	NNP
en-wikipedia-org-4107	621	8	SJ	SJ	NNP
en-wikipedia-org-4107	621	9	,	,	,
en-wikipedia-org-4107	621	10	Kao	Kao	NNP
en-wikipedia-org-4107	621	11	U	U	NNP
en-wikipedia-org-4107	621	12	,	,	,
en-wikipedia-org-4107	621	13	Ling	Ling	NNP
en-wikipedia-org-4107	621	14	W	W	NNP
en-wikipedia-org-4107	621	15	(	(	-LRB-
en-wikipedia-org-4107	621	16	January	January	NNP
en-wikipedia-org-4107	621	17	2009	2009	CD
en-wikipedia-org-4107	621	18	)	)	-RRB-
en-wikipedia-org-4107	621	19	.	.	.
en-wikipedia-org-4107	622	1	Shoptaw	Shoptaw	NNP
en-wikipedia-org-4107	622	2	SJ	SJ	NNP
en-wikipedia-org-4107	622	3	,	,	,
en-wikipedia-org-4107	622	4	Ali	Ali	NNP
en-wikipedia-org-4107	622	5	R	R	NNP
en-wikipedia-org-4107	622	6	(	(	-LRB-
en-wikipedia-org-4107	622	7	ed	ed	NNP
en-wikipedia-org-4107	622	8	.	.	.
en-wikipedia-org-4107	622	9	)	)	-RRB-
en-wikipedia-org-4107	622	10	.	.	.
en-wikipedia-org-4107	623	1	"	"	``
en-wikipedia-org-4107	623	2	Treatment	treatment	NN
en-wikipedia-org-4107	623	3	for	for	IN
en-wikipedia-org-4107	623	4	amphetamine	amphetamine	NN
en-wikipedia-org-4107	623	5	psychosis	psychosis	NN
en-wikipedia-org-4107	623	6	"	"	''
en-wikipedia-org-4107	623	7	.	.	.
en-wikipedia-org-4107	624	1	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	624	2	Database	Database	NNP
en-wikipedia-org-4107	624	3	of	of	IN
en-wikipedia-org-4107	624	4	Systematic	Systematic	NNP
en-wikipedia-org-4107	624	5	Reviews	Reviews	NNPS
en-wikipedia-org-4107	624	6	(	(	-LRB-
en-wikipedia-org-4107	624	7	1	1	CD
en-wikipedia-org-4107	624	8	)	)	-RRB-
en-wikipedia-org-4107	624	9	:	:	:
en-wikipedia-org-4107	624	10	CD003026	cd003026	UH
en-wikipedia-org-4107	624	11	.	.	.
en-wikipedia-org-4107	625	1	doi:10.1002/14651858.CD003026.pub3	doi:10.1002/14651858.cd003026.pub3	UH
en-wikipedia-org-4107	625	2	.	.	.
en-wikipedia-org-4107	626	1	PMC	PMC	NNP
en-wikipedia-org-4107	626	2	 	  	_SP
en-wikipedia-org-4107	626	3	7004251	7004251	CD
en-wikipedia-org-4107	626	4	.	.	.
en-wikipedia-org-4107	627	1	PMID	PMID	NNP
en-wikipedia-org-4107	627	2	 	  	_SP
en-wikipedia-org-4107	627	3	19160215	19160215	CD
en-wikipedia-org-4107	627	4	.	.	.
en-wikipedia-org-4107	628	1	A	a	DT
en-wikipedia-org-4107	628	2	minority	minority	NN
en-wikipedia-org-4107	628	3	of	of	IN
en-wikipedia-org-4107	628	4	individuals	individual	NNS
en-wikipedia-org-4107	628	5	who	who	WP
en-wikipedia-org-4107	628	6	use	use	VBP
en-wikipedia-org-4107	628	7	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	628	8	develop	develop	VBP
en-wikipedia-org-4107	628	9	full	full	RB
en-wikipedia-org-4107	628	10	-	-	HYPH
en-wikipedia-org-4107	628	11	blown	blow	VBN
en-wikipedia-org-4107	628	12	psychosis	psychosis	NN
en-wikipedia-org-4107	628	13	requiring	require	VBG
en-wikipedia-org-4107	628	14	care	care	NN
en-wikipedia-org-4107	628	15	at	at	IN
en-wikipedia-org-4107	628	16	emergency	emergency	NN
en-wikipedia-org-4107	628	17	departments	department	NNS
en-wikipedia-org-4107	628	18	or	or	CC
en-wikipedia-org-4107	628	19	psychiatric	psychiatric	JJ
en-wikipedia-org-4107	628	20	hospitals	hospital	NNS
en-wikipedia-org-4107	628	21	.	.	.
en-wikipedia-org-4107	629	1	In	in	IN
en-wikipedia-org-4107	629	2	such	such	JJ
en-wikipedia-org-4107	629	3	cases	case	NNS
en-wikipedia-org-4107	629	4	,	,	,
en-wikipedia-org-4107	629	5	symptoms	symptom	NNS
en-wikipedia-org-4107	629	6	of	of	IN
en-wikipedia-org-4107	629	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	629	8	psychosis	psychosis	NN
en-wikipedia-org-4107	629	9	commonly	commonly	RB
en-wikipedia-org-4107	629	10	include	include	VBP
en-wikipedia-org-4107	629	11	paranoid	paranoid	JJ
en-wikipedia-org-4107	629	12	and	and	CC
en-wikipedia-org-4107	629	13	persecutory	persecutory	JJ
en-wikipedia-org-4107	629	14	delusions	delusion	NNS
en-wikipedia-org-4107	629	15	as	as	RB
en-wikipedia-org-4107	629	16	well	well	RB
en-wikipedia-org-4107	629	17	as	as	IN
en-wikipedia-org-4107	629	18	auditory	auditory	JJ
en-wikipedia-org-4107	629	19	and	and	CC
en-wikipedia-org-4107	629	20	visual	visual	JJ
en-wikipedia-org-4107	629	21	hallucinations	hallucination	NNS
en-wikipedia-org-4107	629	22	in	in	IN
en-wikipedia-org-4107	629	23	the	the	DT
en-wikipedia-org-4107	629	24	presence	presence	NN
en-wikipedia-org-4107	629	25	of	of	IN
en-wikipedia-org-4107	629	26	extreme	extreme	JJ
en-wikipedia-org-4107	629	27	agitation	agitation	NN
en-wikipedia-org-4107	629	28	.	.	.
en-wikipedia-org-4107	630	1	More	more	RBR
en-wikipedia-org-4107	630	2	common	common	JJ
en-wikipedia-org-4107	630	3	(	(	-LRB-
en-wikipedia-org-4107	630	4	about	about	RB
en-wikipedia-org-4107	630	5	18	18	CD
en-wikipedia-org-4107	630	6	%	%	NN
en-wikipedia-org-4107	630	7	)	)	-RRB-
en-wikipedia-org-4107	630	8	is	be	VBZ
en-wikipedia-org-4107	630	9	for	for	IN
en-wikipedia-org-4107	630	10	frequent	frequent	JJ
en-wikipedia-org-4107	630	11	amphetamine	amphetamine	NN
en-wikipedia-org-4107	630	12	users	user	NNS
en-wikipedia-org-4107	630	13	to	to	TO
en-wikipedia-org-4107	630	14	report	report	VB
en-wikipedia-org-4107	630	15	psychotic	psychotic	JJ
en-wikipedia-org-4107	630	16	symptoms	symptom	NNS
en-wikipedia-org-4107	630	17	that	that	WDT
en-wikipedia-org-4107	630	18	are	be	VBP
en-wikipedia-org-4107	630	19	sub	sub	JJ
en-wikipedia-org-4107	630	20	-	-	JJ
en-wikipedia-org-4107	630	21	clinical	clinical	JJ
en-wikipedia-org-4107	630	22	and	and	CC
en-wikipedia-org-4107	630	23	that	that	WDT
en-wikipedia-org-4107	630	24	do	do	VBP
en-wikipedia-org-4107	630	25	not	not	RB
en-wikipedia-org-4107	630	26	require	require	VB
en-wikipedia-org-4107	630	27	high	high	JJ
en-wikipedia-org-4107	630	28	-	-	HYPH
en-wikipedia-org-4107	630	29	intensity	intensity	NN
en-wikipedia-org-4107	630	30	intervention	intervention	NN
en-wikipedia-org-4107	630	31	 	  	_SP
en-wikipedia-org-4107	630	32	...	...	:
en-wikipedia-org-4107	630	33	About	about	RB
en-wikipedia-org-4107	630	34	5–15	5–15	CD
en-wikipedia-org-4107	630	35	%	%	NN
en-wikipedia-org-4107	630	36	of	of	IN
en-wikipedia-org-4107	630	37	the	the	DT
en-wikipedia-org-4107	630	38	users	user	NNS
en-wikipedia-org-4107	630	39	who	who	WP
en-wikipedia-org-4107	630	40	develop	develop	VBP
en-wikipedia-org-4107	630	41	an	an	DT
en-wikipedia-org-4107	630	42	amphetamine	amphetamine	NN
en-wikipedia-org-4107	630	43	psychosis	psychosis	NN
en-wikipedia-org-4107	630	44	fail	fail	VB
en-wikipedia-org-4107	630	45	to	to	TO
en-wikipedia-org-4107	630	46	recover	recover	VB
en-wikipedia-org-4107	630	47	completely	completely	RB
en-wikipedia-org-4107	630	48	(	(	-LRB-
en-wikipedia-org-4107	630	49	Hofmann	Hofmann	NNP
en-wikipedia-org-4107	630	50	1983	1983	CD
en-wikipedia-org-4107	630	51	)	)	-RRB-
en-wikipedia-org-4107	630	52	 	  	_SP
en-wikipedia-org-4107	630	53	...	...	:
en-wikipedia-org-4107	631	1	Findings	finding	NNS
en-wikipedia-org-4107	631	2	from	from	IN
en-wikipedia-org-4107	631	3	one	one	CD
en-wikipedia-org-4107	631	4	trial	trial	NN
en-wikipedia-org-4107	631	5	indicate	indicate	VBP
en-wikipedia-org-4107	631	6	use	use	NN
en-wikipedia-org-4107	631	7	of	of	IN
en-wikipedia-org-4107	631	8	antipsychotic	antipsychotic	JJ
en-wikipedia-org-4107	631	9	medications	medication	NNS
en-wikipedia-org-4107	631	10	effectively	effectively	RB
en-wikipedia-org-4107	631	11	resolves	resolve	VBZ
en-wikipedia-org-4107	631	12	symptoms	symptom	NNS
en-wikipedia-org-4107	631	13	of	of	IN
en-wikipedia-org-4107	631	14	acute	acute	JJ
en-wikipedia-org-4107	631	15	amphetamine	amphetamine	NN
en-wikipedia-org-4107	631	16	psychosis	psychosis	NN
en-wikipedia-org-4107	631	17	.	.	.
en-wikipedia-org-4107	632	1	psychotic	psychotic	JJ
en-wikipedia-org-4107	632	2	symptoms	symptom	NNS
en-wikipedia-org-4107	632	3	of	of	IN
en-wikipedia-org-4107	632	4	individuals	individual	NNS
en-wikipedia-org-4107	632	5	with	with	IN
en-wikipedia-org-4107	632	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	632	7	psychosis	psychosis	NN
en-wikipedia-org-4107	632	8	may	may	MD
en-wikipedia-org-4107	632	9	be	be	VB
en-wikipedia-org-4107	632	10	due	due	JJ
en-wikipedia-org-4107	632	11	exclusively	exclusively	RB
en-wikipedia-org-4107	632	12	to	to	IN
en-wikipedia-org-4107	632	13	heavy	heavy	JJ
en-wikipedia-org-4107	632	14	use	use	NN
en-wikipedia-org-4107	632	15	of	of	IN
en-wikipedia-org-4107	632	16	the	the	DT
en-wikipedia-org-4107	632	17	drug	drug	NN
en-wikipedia-org-4107	632	18	or	or	CC
en-wikipedia-org-4107	632	19	heavy	heavy	JJ
en-wikipedia-org-4107	632	20	use	use	NN
en-wikipedia-org-4107	632	21	of	of	IN
en-wikipedia-org-4107	632	22	the	the	DT
en-wikipedia-org-4107	632	23	drug	drug	NN
en-wikipedia-org-4107	632	24	may	may	MD
en-wikipedia-org-4107	632	25	exacerbate	exacerbate	VB
en-wikipedia-org-4107	632	26	an	an	DT
en-wikipedia-org-4107	632	27	underlying	underlying	JJ
en-wikipedia-org-4107	632	28	vulnerability	vulnerability	NN
en-wikipedia-org-4107	632	29	to	to	TO
en-wikipedia-org-4107	632	30	schizophrenia	schizophrenia	VB
en-wikipedia-org-4107	632	31	.	.	.
en-wikipedia-org-4107	633	1	^	^	NNP
en-wikipedia-org-4107	633	2	a	a	DT
en-wikipedia-org-4107	633	3	b	b	NNP
en-wikipedia-org-4107	633	4	c	c	NN
en-wikipedia-org-4107	633	5	d	d	NN
en-wikipedia-org-4107	633	6	e	e	NN
en-wikipedia-org-4107	633	7	Bramness	Bramness	NNP
en-wikipedia-org-4107	633	8	JG	JG	NNP
en-wikipedia-org-4107	633	9	,	,	,
en-wikipedia-org-4107	633	10	Gundersen	Gundersen	NNP
en-wikipedia-org-4107	633	11	ØH	ØH	NNP
en-wikipedia-org-4107	633	12	,	,	,
en-wikipedia-org-4107	633	13	Guterstam	Guterstam	NNP
en-wikipedia-org-4107	633	14	J	J	NNP
en-wikipedia-org-4107	633	15	,	,	,
en-wikipedia-org-4107	633	16	Rognli	Rognli	NNP
en-wikipedia-org-4107	633	17	EB	EB	NNP
en-wikipedia-org-4107	633	18	,	,	,
en-wikipedia-org-4107	633	19	Konstenius	Konstenius	NNP
en-wikipedia-org-4107	633	20	M	M	NNP
en-wikipedia-org-4107	633	21	,	,	,
en-wikipedia-org-4107	633	22	Løberg	Løberg	NNP
en-wikipedia-org-4107	633	23	EM	EM	NNP
en-wikipedia-org-4107	633	24	,	,	,
en-wikipedia-org-4107	633	25	Medhus	Medhus	NNP
en-wikipedia-org-4107	633	26	S	S	NNP
en-wikipedia-org-4107	633	27	,	,	,
en-wikipedia-org-4107	633	28	Tanum	Tanum	NNP
en-wikipedia-org-4107	633	29	L	L	NNP
en-wikipedia-org-4107	633	30	,	,	,
en-wikipedia-org-4107	633	31	Franck	Franck	NNP
en-wikipedia-org-4107	633	32	J	J	NNP
en-wikipedia-org-4107	633	33	(	(	-LRB-
en-wikipedia-org-4107	633	34	December	December	NNP
en-wikipedia-org-4107	633	35	2012	2012	CD
en-wikipedia-org-4107	633	36	)	)	-RRB-
en-wikipedia-org-4107	633	37	.	.	.
en-wikipedia-org-4107	634	1	"	"	``
en-wikipedia-org-4107	634	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	634	3	-	-	HYPH
en-wikipedia-org-4107	634	4	induced	induce	VBN
en-wikipedia-org-4107	634	5	psychosis	psychosis	NN
en-wikipedia-org-4107	634	6	—	—	:
en-wikipedia-org-4107	634	7	a	a	DT
en-wikipedia-org-4107	634	8	separate	separate	JJ
en-wikipedia-org-4107	634	9	diagnostic	diagnostic	JJ
en-wikipedia-org-4107	634	10	entity	entity	NN
en-wikipedia-org-4107	634	11	or	or	CC
en-wikipedia-org-4107	634	12	primary	primary	JJ
en-wikipedia-org-4107	634	13	psychosis	psychosis	NN
en-wikipedia-org-4107	634	14	triggered	trigger	VBN
en-wikipedia-org-4107	634	15	in	in	IN
en-wikipedia-org-4107	634	16	the	the	DT
en-wikipedia-org-4107	634	17	vulnerable	vulnerable	NN
en-wikipedia-org-4107	634	18	?	?	.
en-wikipedia-org-4107	634	19	"	"	''
en-wikipedia-org-4107	634	20	.	.	.
en-wikipedia-org-4107	635	1	BMC	BMC	NNP
en-wikipedia-org-4107	635	2	Psychiatry	Psychiatry	NNP
en-wikipedia-org-4107	635	3	.	.	.
en-wikipedia-org-4107	636	1	12	12	CD
en-wikipedia-org-4107	636	2	:	:	SYM
en-wikipedia-org-4107	636	3	221	221	CD
en-wikipedia-org-4107	636	4	.	.	.
en-wikipedia-org-4107	636	5	doi:10.1186/1471	doi:10.1186/1471	JJ
en-wikipedia-org-4107	636	6	-	-	HYPH
en-wikipedia-org-4107	636	7	244X-12	244X-12	NNP
en-wikipedia-org-4107	636	8	-	-	HYPH
en-wikipedia-org-4107	636	9	221	221	CD
en-wikipedia-org-4107	636	10	.	.	.
en-wikipedia-org-4107	637	1	PMC	PMC	NNP
en-wikipedia-org-4107	637	2	 	  	_SP
en-wikipedia-org-4107	637	3	3554477	3554477	CD
en-wikipedia-org-4107	637	4	.	.	.
en-wikipedia-org-4107	638	1	PMID	PMID	NNP
en-wikipedia-org-4107	638	2	 	  	_SP
en-wikipedia-org-4107	638	3	23216941	23216941	CD
en-wikipedia-org-4107	638	4	.	.	.
en-wikipedia-org-4107	639	1	In	in	IN
en-wikipedia-org-4107	639	2	these	these	DT
en-wikipedia-org-4107	639	3	studies	study	NNS
en-wikipedia-org-4107	639	4	,	,	,
en-wikipedia-org-4107	639	5	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	639	6	was	be	VBD
en-wikipedia-org-4107	639	7	given	give	VBN
en-wikipedia-org-4107	639	8	in	in	IN
en-wikipedia-org-4107	639	9	consecutively	consecutively	RB
en-wikipedia-org-4107	639	10	higher	high	JJR
en-wikipedia-org-4107	639	11	doses	dose	NNS
en-wikipedia-org-4107	639	12	until	until	IN
en-wikipedia-org-4107	639	13	psychosis	psychosis	NN
en-wikipedia-org-4107	639	14	was	be	VBD
en-wikipedia-org-4107	639	15	precipitated	precipitate	VBN
en-wikipedia-org-4107	639	16	,	,	,
en-wikipedia-org-4107	639	17	often	often	RB
en-wikipedia-org-4107	639	18	after	after	IN
en-wikipedia-org-4107	639	19	100–300	100–300	CD
en-wikipedia-org-4107	639	20	mg	mg	NNP
en-wikipedia-org-4107	639	21	of	of	IN
en-wikipedia-org-4107	639	22	amphetamine	amphetamine	NN
en-wikipedia-org-4107	639	23	 	  	_SP
en-wikipedia-org-4107	639	24	...	...	.
en-wikipedia-org-4107	639	25	Secondly	secondly	RB
en-wikipedia-org-4107	639	26	,	,	,
en-wikipedia-org-4107	639	27	psychosis	psychosis	NN
en-wikipedia-org-4107	639	28	has	have	VBZ
en-wikipedia-org-4107	639	29	been	be	VBN
en-wikipedia-org-4107	639	30	viewed	view	VBN
en-wikipedia-org-4107	639	31	as	as	IN
en-wikipedia-org-4107	639	32	an	an	DT
en-wikipedia-org-4107	639	33	adverse	adverse	JJ
en-wikipedia-org-4107	639	34	event	event	NN
en-wikipedia-org-4107	639	35	,	,	,
en-wikipedia-org-4107	639	36	although	although	IN
en-wikipedia-org-4107	639	37	rare	rare	JJ
en-wikipedia-org-4107	639	38	,	,	,
en-wikipedia-org-4107	639	39	in	in	IN
en-wikipedia-org-4107	639	40	children	child	NNS
en-wikipedia-org-4107	639	41	with	with	IN
en-wikipedia-org-4107	639	42	ADHD	ADHD	NNP
en-wikipedia-org-4107	639	43	who	who	WP
en-wikipedia-org-4107	639	44	have	have	VBP
en-wikipedia-org-4107	639	45	been	be	VBN
en-wikipedia-org-4107	639	46	treated	treat	VBN
en-wikipedia-org-4107	639	47	with	with	IN
en-wikipedia-org-4107	639	48	amphetamine	amphetamine	NN
en-wikipedia-org-4107	639	49	^	^	NNP
en-wikipedia-org-4107	639	50	a	a	DT
en-wikipedia-org-4107	639	51	b	b	NN
en-wikipedia-org-4107	639	52	c	c	NN
en-wikipedia-org-4107	639	53	Greydanus	Greydanus	NNP
en-wikipedia-org-4107	639	54	D.	D.	NNP
en-wikipedia-org-4107	639	55	"	"	''
en-wikipedia-org-4107	639	56	Stimulant	Stimulant	NNP
en-wikipedia-org-4107	639	57	Misuse	Misuse	NNP
en-wikipedia-org-4107	639	58	:	:	:
en-wikipedia-org-4107	639	59	Strategies	strategy	NNS
en-wikipedia-org-4107	639	60	to	to	TO
en-wikipedia-org-4107	639	61	Manage	manage	VB
en-wikipedia-org-4107	639	62	a	a	DT
en-wikipedia-org-4107	639	63	Growing	grow	VBG
en-wikipedia-org-4107	639	64	Problem	problem	NN
en-wikipedia-org-4107	639	65	"	"	''
en-wikipedia-org-4107	639	66	(	(	-LRB-
en-wikipedia-org-4107	639	67	PDF	PDF	NNP
en-wikipedia-org-4107	639	68	)	)	-RRB-
en-wikipedia-org-4107	639	69	.	.	.
en-wikipedia-org-4107	640	1	American	American	NNP
en-wikipedia-org-4107	640	2	College	College	NNP
en-wikipedia-org-4107	640	3	Health	Health	NNP
en-wikipedia-org-4107	640	4	Association	Association	NNP
en-wikipedia-org-4107	640	5	(	(	-LRB-
en-wikipedia-org-4107	640	6	Review	Review	NNP
en-wikipedia-org-4107	640	7	Article	Article	NNP
en-wikipedia-org-4107	640	8	)	)	-RRB-
en-wikipedia-org-4107	640	9	.	.	.
en-wikipedia-org-4107	641	1	ACHA	ACHA	NNP
en-wikipedia-org-4107	641	2	Professional	Professional	NNP
en-wikipedia-org-4107	641	3	Development	Development	NNP
en-wikipedia-org-4107	641	4	Program	Program	NNP
en-wikipedia-org-4107	641	5	.	.	.
en-wikipedia-org-4107	642	1	p.	p.	NN
en-wikipedia-org-4107	642	2	 	  	_SP
en-wikipedia-org-4107	642	3	20	20	CD
en-wikipedia-org-4107	642	4	.	.	.
en-wikipedia-org-4107	643	1	Archived	archived	JJ
en-wikipedia-org-4107	643	2	from	from	IN
en-wikipedia-org-4107	643	3	the	the	DT
en-wikipedia-org-4107	643	4	original	original	JJ
en-wikipedia-org-4107	643	5	(	(	-LRB-
en-wikipedia-org-4107	643	6	PDF	PDF	NNP
en-wikipedia-org-4107	643	7	)	)	-RRB-
en-wikipedia-org-4107	643	8	on	on	IN
en-wikipedia-org-4107	643	9	3	3	CD
en-wikipedia-org-4107	643	10	November	November	NNP
en-wikipedia-org-4107	643	11	2013	2013	CD
en-wikipedia-org-4107	643	12	.	.	.
en-wikipedia-org-4107	644	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	644	2	2	2	CD
en-wikipedia-org-4107	644	3	November	November	NNP
en-wikipedia-org-4107	644	4	2013	2013	CD
en-wikipedia-org-4107	644	5	.	.	.
en-wikipedia-org-4107	645	1	^	^	NNP
en-wikipedia-org-4107	645	2	a	a	DT
en-wikipedia-org-4107	645	3	b	b	NNP
en-wikipedia-org-4107	645	4	c	c	NNP
en-wikipedia-org-4107	645	5	d	d	NNP
en-wikipedia-org-4107	645	6	e	e	NNP
en-wikipedia-org-4107	645	7	f	f	NNP
en-wikipedia-org-4107	645	8	g	g	NNP
en-wikipedia-org-4107	645	9	h	h	NN
en-wikipedia-org-4107	645	10	Huang	Huang	NNP
en-wikipedia-org-4107	645	11	YS	YS	NNP
en-wikipedia-org-4107	645	12	,	,	,
en-wikipedia-org-4107	645	13	Tsai	Tsai	NNP
en-wikipedia-org-4107	645	14	MH	MH	NNP
en-wikipedia-org-4107	645	15	(	(	-LRB-
en-wikipedia-org-4107	645	16	July	July	NNP
en-wikipedia-org-4107	645	17	2011	2011	CD
en-wikipedia-org-4107	645	18	)	)	-RRB-
en-wikipedia-org-4107	645	19	.	.	.
en-wikipedia-org-4107	646	1	"	"	``
en-wikipedia-org-4107	646	2	Long	long	JJ
en-wikipedia-org-4107	646	3	-	-	HYPH
en-wikipedia-org-4107	646	4	term	term	NN
en-wikipedia-org-4107	646	5	outcomes	outcome	NNS
en-wikipedia-org-4107	646	6	with	with	IN
en-wikipedia-org-4107	646	7	medications	medication	NNS
en-wikipedia-org-4107	646	8	for	for	IN
en-wikipedia-org-4107	646	9	attention	attention	NN
en-wikipedia-org-4107	646	10	-	-	HYPH
en-wikipedia-org-4107	646	11	deficit	deficit	NN
en-wikipedia-org-4107	646	12	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	646	13	disorder	disorder	NN
en-wikipedia-org-4107	646	14	:	:	:
en-wikipedia-org-4107	646	15	current	current	JJ
en-wikipedia-org-4107	646	16	status	status	NN
en-wikipedia-org-4107	646	17	of	of	IN
en-wikipedia-org-4107	646	18	knowledge	knowledge	NN
en-wikipedia-org-4107	646	19	"	"	''
en-wikipedia-org-4107	646	20	.	.	.
en-wikipedia-org-4107	647	1	CNS	CNS	NNP
en-wikipedia-org-4107	647	2	Drugs	drug	NNS
en-wikipedia-org-4107	647	3	.	.	.
en-wikipedia-org-4107	648	1	25	25	CD
en-wikipedia-org-4107	648	2	(	(	-LRB-
en-wikipedia-org-4107	648	3	7	7	CD
en-wikipedia-org-4107	648	4	)	)	-RRB-
en-wikipedia-org-4107	648	5	:	:	:
en-wikipedia-org-4107	648	6	539–554	539–554	CD
en-wikipedia-org-4107	648	7	.	.	.
en-wikipedia-org-4107	649	1	doi:10.2165/11589380	doi:10.2165/11589380	NNP
en-wikipedia-org-4107	649	2	-	-	HYPH
en-wikipedia-org-4107	649	3	000000000	000000000	CD
en-wikipedia-org-4107	649	4	-	-	HYPH
en-wikipedia-org-4107	649	5	00000	00000	CD
en-wikipedia-org-4107	649	6	.	.	.
en-wikipedia-org-4107	650	1	PMID	PMID	NNP
en-wikipedia-org-4107	650	2	 	  	_SP
en-wikipedia-org-4107	650	3	21699268	21699268	CD
en-wikipedia-org-4107	650	4	.	.	.
en-wikipedia-org-4107	651	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	651	2	 	  	_SP
en-wikipedia-org-4107	651	3	3449435	3449435	CD
en-wikipedia-org-4107	651	4	.	.	.
en-wikipedia-org-4107	652	1	Several	several	JJ
en-wikipedia-org-4107	652	2	other	other	JJ
en-wikipedia-org-4107	652	3	studies,[97	studies,[97	CD
en-wikipedia-org-4107	652	4	-	-	SYM
en-wikipedia-org-4107	652	5	101	101	CD
en-wikipedia-org-4107	652	6	]	]	-RRB-
en-wikipedia-org-4107	652	7	including	include	VBG
en-wikipedia-org-4107	652	8	a	a	DT
en-wikipedia-org-4107	652	9	meta	meta	JJ
en-wikipedia-org-4107	652	10	-	-	HYPH
en-wikipedia-org-4107	652	11	analytic	analytic	JJ
en-wikipedia-org-4107	652	12	review[98	review[98	NN
en-wikipedia-org-4107	652	13	]	]	-RRB-
en-wikipedia-org-4107	652	14	and	and	CC
en-wikipedia-org-4107	652	15	a	a	DT
en-wikipedia-org-4107	652	16	retrospective	retrospective	JJ
en-wikipedia-org-4107	652	17	study,[97	study,[97	NN
en-wikipedia-org-4107	652	18	]	]	-RRB-
en-wikipedia-org-4107	652	19	suggested	suggest	VBD
en-wikipedia-org-4107	652	20	that	that	IN
en-wikipedia-org-4107	652	21	stimulant	stimulant	NN
en-wikipedia-org-4107	652	22	therapy	therapy	NN
en-wikipedia-org-4107	652	23	in	in	IN
en-wikipedia-org-4107	652	24	childhood	childhood	NN
en-wikipedia-org-4107	652	25	is	be	VBZ
en-wikipedia-org-4107	652	26	associated	associate	VBN
en-wikipedia-org-4107	652	27	with	with	IN
en-wikipedia-org-4107	652	28	a	a	DT
en-wikipedia-org-4107	652	29	reduced	reduce	VBN
en-wikipedia-org-4107	652	30	risk	risk	NN
en-wikipedia-org-4107	652	31	of	of	IN
en-wikipedia-org-4107	652	32	subsequent	subsequent	JJ
en-wikipedia-org-4107	652	33	substance	substance	NN
en-wikipedia-org-4107	652	34	use	use	NN
en-wikipedia-org-4107	652	35	,	,	,
en-wikipedia-org-4107	652	36	cigarette	cigarette	NN
en-wikipedia-org-4107	652	37	smoking	smoking	NN
en-wikipedia-org-4107	652	38	and	and	CC
en-wikipedia-org-4107	652	39	alcohol	alcohol	NN
en-wikipedia-org-4107	652	40	use	use	NN
en-wikipedia-org-4107	652	41	disorders	disorder	NNS
en-wikipedia-org-4107	652	42	.	.	.
en-wikipedia-org-4107	653	1	...	...	NFP
en-wikipedia-org-4107	654	1	Recent	recent	JJ
en-wikipedia-org-4107	654	2	studies	study	NNS
en-wikipedia-org-4107	654	3	have	have	VBP
en-wikipedia-org-4107	654	4	demonstrated	demonstrate	VBN
en-wikipedia-org-4107	654	5	that	that	IN
en-wikipedia-org-4107	654	6	stimulants	stimulant	NNS
en-wikipedia-org-4107	654	7	,	,	,
en-wikipedia-org-4107	654	8	along	along	IN
en-wikipedia-org-4107	654	9	with	with	IN
en-wikipedia-org-4107	654	10	the	the	DT
en-wikipedia-org-4107	654	11	non	non	JJ
en-wikipedia-org-4107	654	12	-	-	JJ
en-wikipedia-org-4107	654	13	stimulants	stimulants	JJ
en-wikipedia-org-4107	654	14	atomoxetine	atomoxetine	NN
en-wikipedia-org-4107	654	15	and	and	CC
en-wikipedia-org-4107	654	16	extended	extended	JJ
en-wikipedia-org-4107	654	17	-	-	HYPH
en-wikipedia-org-4107	654	18	release	release	NN
en-wikipedia-org-4107	654	19	guanfacine	guanfacine	NN
en-wikipedia-org-4107	654	20	,	,	,
en-wikipedia-org-4107	654	21	are	be	VBP
en-wikipedia-org-4107	654	22	continuously	continuously	RB
en-wikipedia-org-4107	654	23	effective	effective	JJ
en-wikipedia-org-4107	654	24	for	for	IN
en-wikipedia-org-4107	654	25	more	more	JJR
en-wikipedia-org-4107	654	26	than	than	IN
en-wikipedia-org-4107	654	27	2-year	2-year	CD
en-wikipedia-org-4107	654	28	treatment	treatment	NN
en-wikipedia-org-4107	654	29	periods	period	NNS
en-wikipedia-org-4107	654	30	with	with	IN
en-wikipedia-org-4107	654	31	few	few	JJ
en-wikipedia-org-4107	654	32	and	and	CC
en-wikipedia-org-4107	654	33	tolerable	tolerable	JJ
en-wikipedia-org-4107	654	34	adverse	adverse	JJ
en-wikipedia-org-4107	654	35	effects	effect	NNS
en-wikipedia-org-4107	654	36	.	.	.
en-wikipedia-org-4107	655	1	The	the	DT
en-wikipedia-org-4107	655	2	effectiveness	effectiveness	NN
en-wikipedia-org-4107	655	3	of	of	IN
en-wikipedia-org-4107	655	4	long	long	JJ
en-wikipedia-org-4107	655	5	-	-	HYPH
en-wikipedia-org-4107	655	6	term	term	NN
en-wikipedia-org-4107	655	7	therapy	therapy	NN
en-wikipedia-org-4107	655	8	includes	include	VBZ
en-wikipedia-org-4107	655	9	not	not	RB
en-wikipedia-org-4107	655	10	only	only	RB
en-wikipedia-org-4107	655	11	the	the	DT
en-wikipedia-org-4107	655	12	core	core	NN
en-wikipedia-org-4107	655	13	symptoms	symptom	NNS
en-wikipedia-org-4107	655	14	of	of	IN
en-wikipedia-org-4107	655	15	ADHD	ADHD	NNP
en-wikipedia-org-4107	655	16	,	,	,
en-wikipedia-org-4107	655	17	but	but	CC
en-wikipedia-org-4107	655	18	also	also	RB
en-wikipedia-org-4107	655	19	improved	improve	VBN
en-wikipedia-org-4107	655	20	quality	quality	NN
en-wikipedia-org-4107	655	21	of	of	IN
en-wikipedia-org-4107	655	22	life	life	NN
en-wikipedia-org-4107	655	23	and	and	CC
en-wikipedia-org-4107	655	24	academic	academic	JJ
en-wikipedia-org-4107	655	25	achievements	achievement	NNS
en-wikipedia-org-4107	655	26	.	.	.
en-wikipedia-org-4107	656	1	The	the	DT
en-wikipedia-org-4107	656	2	most	most	RBS
en-wikipedia-org-4107	656	3	concerning	concern	VBG
en-wikipedia-org-4107	656	4	short	short	JJ
en-wikipedia-org-4107	656	5	-	-	HYPH
en-wikipedia-org-4107	656	6	term	term	NN
en-wikipedia-org-4107	656	7	adverse	adverse	JJ
en-wikipedia-org-4107	656	8	effects	effect	NNS
en-wikipedia-org-4107	656	9	of	of	IN
en-wikipedia-org-4107	656	10	stimulants	stimulant	NNS
en-wikipedia-org-4107	656	11	,	,	,
en-wikipedia-org-4107	656	12	such	such	JJ
en-wikipedia-org-4107	656	13	as	as	IN
en-wikipedia-org-4107	656	14	elevated	elevated	JJ
en-wikipedia-org-4107	656	15	blood	blood	NN
en-wikipedia-org-4107	656	16	pressure	pressure	NN
en-wikipedia-org-4107	656	17	and	and	CC
en-wikipedia-org-4107	656	18	heart	heart	NN
en-wikipedia-org-4107	656	19	rate	rate	NN
en-wikipedia-org-4107	656	20	,	,	,
en-wikipedia-org-4107	656	21	waned	wane	VBN
en-wikipedia-org-4107	656	22	in	in	IN
en-wikipedia-org-4107	656	23	long	long	JJ
en-wikipedia-org-4107	656	24	-	-	HYPH
en-wikipedia-org-4107	656	25	term	term	NN
en-wikipedia-org-4107	656	26	follow	follow	NN
en-wikipedia-org-4107	656	27	-	-	HYPH
en-wikipedia-org-4107	656	28	up	up	RP
en-wikipedia-org-4107	656	29	studies	study	NNS
en-wikipedia-org-4107	656	30	.	.	.
en-wikipedia-org-4107	657	1	...	...	NFP
en-wikipedia-org-4107	658	1	The	the	DT
en-wikipedia-org-4107	658	2	current	current	JJ
en-wikipedia-org-4107	658	3	data	datum	NNS
en-wikipedia-org-4107	658	4	do	do	VBP
en-wikipedia-org-4107	658	5	not	not	RB
en-wikipedia-org-4107	658	6	support	support	VB
en-wikipedia-org-4107	658	7	the	the	DT
en-wikipedia-org-4107	658	8	potential	potential	JJ
en-wikipedia-org-4107	658	9	impact	impact	NN
en-wikipedia-org-4107	658	10	of	of	IN
en-wikipedia-org-4107	658	11	stimulants	stimulant	NNS
en-wikipedia-org-4107	658	12	on	on	IN
en-wikipedia-org-4107	658	13	the	the	DT
en-wikipedia-org-4107	658	14	worsening	worsening	NN
en-wikipedia-org-4107	658	15	or	or	CC
en-wikipedia-org-4107	658	16	development	development	NN
en-wikipedia-org-4107	658	17	of	of	IN
en-wikipedia-org-4107	658	18	tics	tic	NNS
en-wikipedia-org-4107	658	19	or	or	CC
en-wikipedia-org-4107	658	20	substance	substance	NN
en-wikipedia-org-4107	658	21	abuse	abuse	NN
en-wikipedia-org-4107	658	22	into	into	IN
en-wikipedia-org-4107	658	23	adulthood	adulthood	NN
en-wikipedia-org-4107	658	24	.	.	.
en-wikipedia-org-4107	659	1	In	in	IN
en-wikipedia-org-4107	659	2	the	the	DT
en-wikipedia-org-4107	659	3	longest	long	JJS
en-wikipedia-org-4107	659	4	follow	follow	NN
en-wikipedia-org-4107	659	5	-	-	HYPH
en-wikipedia-org-4107	659	6	up	up	NN
en-wikipedia-org-4107	659	7	study	study	NN
en-wikipedia-org-4107	659	8	(	(	-LRB-
en-wikipedia-org-4107	659	9	of	of	IN
en-wikipedia-org-4107	659	10	more	more	JJR
en-wikipedia-org-4107	659	11	than	than	IN
en-wikipedia-org-4107	659	12	10	10	CD
en-wikipedia-org-4107	659	13	 	  	_SP
en-wikipedia-org-4107	659	14	years	year	NNS
en-wikipedia-org-4107	659	15	)	)	-RRB-
en-wikipedia-org-4107	659	16	,	,	,
en-wikipedia-org-4107	659	17	lifetime	lifetime	NN
en-wikipedia-org-4107	659	18	stimulant	stimulant	NN
en-wikipedia-org-4107	659	19	treatment	treatment	NN
en-wikipedia-org-4107	659	20	for	for	IN
en-wikipedia-org-4107	659	21	ADHD	ADHD	NNP
en-wikipedia-org-4107	659	22	was	be	VBD
en-wikipedia-org-4107	659	23	effective	effective	JJ
en-wikipedia-org-4107	659	24	and	and	CC
en-wikipedia-org-4107	659	25	protective	protective	JJ
en-wikipedia-org-4107	659	26	against	against	IN
en-wikipedia-org-4107	659	27	the	the	DT
en-wikipedia-org-4107	659	28	development	development	NN
en-wikipedia-org-4107	659	29	of	of	IN
en-wikipedia-org-4107	659	30	adverse	adverse	JJ
en-wikipedia-org-4107	659	31	psychiatric	psychiatric	JJ
en-wikipedia-org-4107	659	32	disorders	disorder	NNS
en-wikipedia-org-4107	659	33	.	.	.
en-wikipedia-org-4107	660	1	^	^	NNP
en-wikipedia-org-4107	660	2	a	a	DT
en-wikipedia-org-4107	660	3	b	b	NNP
en-wikipedia-org-4107	660	4	Malenka	Malenka	NNP
en-wikipedia-org-4107	660	5	RC	RC	NNP
en-wikipedia-org-4107	660	6	,	,	,
en-wikipedia-org-4107	660	7	Nestler	Nestler	NNP
en-wikipedia-org-4107	660	8	EJ	EJ	NNP
en-wikipedia-org-4107	660	9	,	,	,
en-wikipedia-org-4107	660	10	Hyman	Hyman	NNP
en-wikipedia-org-4107	660	11	SE	SE	NNP
en-wikipedia-org-4107	660	12	,	,	,
en-wikipedia-org-4107	660	13	Holtzman	Holtzman	NNP
en-wikipedia-org-4107	660	14	DM	DM	NNP
en-wikipedia-org-4107	660	15	(	(	-LRB-
en-wikipedia-org-4107	660	16	2015	2015	CD
en-wikipedia-org-4107	660	17	)	)	-RRB-
en-wikipedia-org-4107	660	18	.	.	.
en-wikipedia-org-4107	661	1	"	"	``
en-wikipedia-org-4107	661	2	Chapter	chapter	NN
en-wikipedia-org-4107	661	3	16	16	CD
en-wikipedia-org-4107	661	4	:	:	:
en-wikipedia-org-4107	661	5	Reinforcement	reinforcement	NN
en-wikipedia-org-4107	661	6	and	and	CC
en-wikipedia-org-4107	661	7	Addictive	Addictive	NNP
en-wikipedia-org-4107	661	8	Disorders	Disorders	NNPS
en-wikipedia-org-4107	661	9	"	"	''
en-wikipedia-org-4107	661	10	.	.	.
en-wikipedia-org-4107	662	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	662	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-4107	662	3	:	:	:
en-wikipedia-org-4107	662	4	A	A	NNP
en-wikipedia-org-4107	662	5	Foundation	Foundation	NNP
en-wikipedia-org-4107	662	6	for	for	IN
en-wikipedia-org-4107	662	7	Clinical	Clinical	NNP
en-wikipedia-org-4107	662	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	662	9	(	(	-LRB-
en-wikipedia-org-4107	662	10	3rd	3rd	NNP
en-wikipedia-org-4107	662	11	ed	ed	NNP
en-wikipedia-org-4107	662	12	.	.	.
en-wikipedia-org-4107	662	13	)	)	-RRB-
en-wikipedia-org-4107	662	14	.	.	.
en-wikipedia-org-4107	663	1	New	New	NNP
en-wikipedia-org-4107	663	2	York	York	NNP
en-wikipedia-org-4107	663	3	:	:	:
en-wikipedia-org-4107	663	4	McGraw	McGraw	NNP
en-wikipedia-org-4107	663	5	-	-	HYPH
en-wikipedia-org-4107	663	6	Hill	Hill	NNP
en-wikipedia-org-4107	663	7	Medical	Medical	NNP
en-wikipedia-org-4107	663	8	.	.	.
en-wikipedia-org-4107	664	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	664	2	 	  	_SP
en-wikipedia-org-4107	664	3	9780071827706	9780071827706	CD
en-wikipedia-org-4107	664	4	.	.	.
en-wikipedia-org-4107	665	1	Such	such	JJ
en-wikipedia-org-4107	665	2	agents	agent	NNS
en-wikipedia-org-4107	665	3	also	also	RB
en-wikipedia-org-4107	665	4	have	have	VBP
en-wikipedia-org-4107	665	5	important	important	JJ
en-wikipedia-org-4107	665	6	therapeutic	therapeutic	JJ
en-wikipedia-org-4107	665	7	uses	use	NNS
en-wikipedia-org-4107	665	8	;	;	:
en-wikipedia-org-4107	665	9	cocaine	cocaine	NN
en-wikipedia-org-4107	665	10	,	,	,
en-wikipedia-org-4107	665	11	for	for	IN
en-wikipedia-org-4107	665	12	example	example	NN
en-wikipedia-org-4107	665	13	,	,	,
en-wikipedia-org-4107	665	14	is	be	VBZ
en-wikipedia-org-4107	665	15	used	use	VBN
en-wikipedia-org-4107	665	16	as	as	IN
en-wikipedia-org-4107	665	17	a	a	DT
en-wikipedia-org-4107	665	18	local	local	JJ
en-wikipedia-org-4107	665	19	anesthetic	anesthetic	NN
en-wikipedia-org-4107	665	20	(	(	-LRB-
en-wikipedia-org-4107	665	21	Chapter	chapter	NN
en-wikipedia-org-4107	665	22	2	2	CD
en-wikipedia-org-4107	665	23	)	)	-RRB-
en-wikipedia-org-4107	665	24	,	,	,
en-wikipedia-org-4107	665	25	and	and	CC
en-wikipedia-org-4107	665	26	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	665	27	and	and	CC
en-wikipedia-org-4107	665	28	methylphenidate	methylphenidate	NN
en-wikipedia-org-4107	665	29	are	be	VBP
en-wikipedia-org-4107	665	30	used	use	VBN
en-wikipedia-org-4107	665	31	in	in	IN
en-wikipedia-org-4107	665	32	low	low	JJ
en-wikipedia-org-4107	665	33	doses	dose	NNS
en-wikipedia-org-4107	665	34	to	to	TO
en-wikipedia-org-4107	665	35	treat	treat	VB
en-wikipedia-org-4107	665	36	attention	attention	NN
en-wikipedia-org-4107	665	37	deficit	deficit	NN
en-wikipedia-org-4107	665	38	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	665	39	disorder	disorder	NN
en-wikipedia-org-4107	665	40	and	and	CC
en-wikipedia-org-4107	665	41	in	in	IN
en-wikipedia-org-4107	665	42	higher	high	JJR
en-wikipedia-org-4107	665	43	doses	dose	NNS
en-wikipedia-org-4107	665	44	to	to	TO
en-wikipedia-org-4107	665	45	treat	treat	VB
en-wikipedia-org-4107	665	46	narcolepsy	narcolepsy	NN
en-wikipedia-org-4107	665	47	(	(	-LRB-
en-wikipedia-org-4107	665	48	Chapter	chapter	NN
en-wikipedia-org-4107	665	49	12	12	CD
en-wikipedia-org-4107	665	50	)	)	-RRB-
en-wikipedia-org-4107	665	51	.	.	.
en-wikipedia-org-4107	666	1	Despite	despite	IN
en-wikipedia-org-4107	666	2	their	-PRON-	PRP$
en-wikipedia-org-4107	666	3	clinical	clinical	JJ
en-wikipedia-org-4107	666	4	uses	use	NNS
en-wikipedia-org-4107	666	5	,	,	,
en-wikipedia-org-4107	666	6	these	these	DT
en-wikipedia-org-4107	666	7	drugs	drug	NNS
en-wikipedia-org-4107	666	8	are	be	VBP
en-wikipedia-org-4107	666	9	strongly	strongly	RB
en-wikipedia-org-4107	666	10	reinforcing	reinforce	VBG
en-wikipedia-org-4107	666	11	,	,	,
en-wikipedia-org-4107	666	12	and	and	CC
en-wikipedia-org-4107	666	13	their	-PRON-	PRP$
en-wikipedia-org-4107	666	14	long	long	JJ
en-wikipedia-org-4107	666	15	-	-	HYPH
en-wikipedia-org-4107	666	16	term	term	NN
en-wikipedia-org-4107	666	17	use	use	NN
en-wikipedia-org-4107	666	18	at	at	IN
en-wikipedia-org-4107	666	19	high	high	JJ
en-wikipedia-org-4107	666	20	doses	dose	NNS
en-wikipedia-org-4107	666	21	is	be	VBZ
en-wikipedia-org-4107	666	22	linked	link	VBN
en-wikipedia-org-4107	666	23	with	with	IN
en-wikipedia-org-4107	666	24	potential	potential	JJ
en-wikipedia-org-4107	666	25	addiction	addiction	NN
en-wikipedia-org-4107	666	26	,	,	,
en-wikipedia-org-4107	666	27	especially	especially	RB
en-wikipedia-org-4107	666	28	when	when	WRB
en-wikipedia-org-4107	666	29	they	-PRON-	PRP
en-wikipedia-org-4107	666	30	are	be	VBP
en-wikipedia-org-4107	666	31	rapidly	rapidly	RB
en-wikipedia-org-4107	666	32	administered	administer	VBN
en-wikipedia-org-4107	666	33	or	or	CC
en-wikipedia-org-4107	666	34	when	when	WRB
en-wikipedia-org-4107	666	35	high	high	JJ
en-wikipedia-org-4107	666	36	-	-	HYPH
en-wikipedia-org-4107	666	37	potency	potency	NN
en-wikipedia-org-4107	666	38	forms	form	NNS
en-wikipedia-org-4107	666	39	are	be	VBP
en-wikipedia-org-4107	666	40	given	give	VBN
en-wikipedia-org-4107	666	41	.	.	.
en-wikipedia-org-4107	667	1	^	^	NNP
en-wikipedia-org-4107	667	2	a	a	DT
en-wikipedia-org-4107	667	3	b	b	NN
en-wikipedia-org-4107	667	4	Kollins	Kollins	NNP
en-wikipedia-org-4107	667	5	SH	SH	NNP
en-wikipedia-org-4107	667	6	(	(	-LRB-
en-wikipedia-org-4107	667	7	May	May	NNP
en-wikipedia-org-4107	667	8	2008	2008	CD
en-wikipedia-org-4107	667	9	)	)	-RRB-
en-wikipedia-org-4107	667	10	.	.	.
en-wikipedia-org-4107	668	1	"	"	``
en-wikipedia-org-4107	668	2	A	a	DT
en-wikipedia-org-4107	668	3	qualitative	qualitative	JJ
en-wikipedia-org-4107	668	4	review	review	NN
en-wikipedia-org-4107	668	5	of	of	IN
en-wikipedia-org-4107	668	6	issues	issue	NNS
en-wikipedia-org-4107	668	7	arising	arise	VBG
en-wikipedia-org-4107	668	8	in	in	IN
en-wikipedia-org-4107	668	9	the	the	DT
en-wikipedia-org-4107	668	10	use	use	NN
en-wikipedia-org-4107	668	11	of	of	IN
en-wikipedia-org-4107	668	12	psycho	psycho	NN
en-wikipedia-org-4107	668	13	-	-	HYPH
en-wikipedia-org-4107	668	14	stimulant	stimulant	NN
en-wikipedia-org-4107	668	15	medications	medication	NNS
en-wikipedia-org-4107	668	16	in	in	IN
en-wikipedia-org-4107	668	17	patients	patient	NNS
en-wikipedia-org-4107	668	18	with	with	IN
en-wikipedia-org-4107	668	19	ADHD	ADHD	NNP
en-wikipedia-org-4107	668	20	and	and	CC
en-wikipedia-org-4107	668	21	co	co	JJ
en-wikipedia-org-4107	668	22	-	-	JJ
en-wikipedia-org-4107	668	23	morbid	morbid	JJ
en-wikipedia-org-4107	668	24	substance	substance	NN
en-wikipedia-org-4107	668	25	use	use	NN
en-wikipedia-org-4107	668	26	disorders	disorder	NNS
en-wikipedia-org-4107	668	27	"	"	''
en-wikipedia-org-4107	668	28	.	.	.
en-wikipedia-org-4107	669	1	Current	Current	NNP
en-wikipedia-org-4107	669	2	Medical	Medical	NNP
en-wikipedia-org-4107	669	3	Research	Research	NNP
en-wikipedia-org-4107	669	4	and	and	CC
en-wikipedia-org-4107	669	5	Opinion	Opinion	NNP
en-wikipedia-org-4107	669	6	.	.	.
en-wikipedia-org-4107	670	1	24	24	CD
en-wikipedia-org-4107	670	2	(	(	-LRB-
en-wikipedia-org-4107	670	3	5	5	CD
en-wikipedia-org-4107	670	4	)	)	-RRB-
en-wikipedia-org-4107	670	5	:	:	:
en-wikipedia-org-4107	670	6	1345–1357	1345–1357	CD
en-wikipedia-org-4107	670	7	.	.	.
en-wikipedia-org-4107	671	1	doi:10.1185/030079908X280707	doi:10.1185/030079908x280707	UH
en-wikipedia-org-4107	671	2	.	.	.
en-wikipedia-org-4107	672	1	PMID	PMID	NNP
en-wikipedia-org-4107	672	2	 	  	_SP
en-wikipedia-org-4107	672	3	18384709	18384709	CD
en-wikipedia-org-4107	672	4	.	.	.
en-wikipedia-org-4107	673	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	673	2	 	  	_SP
en-wikipedia-org-4107	673	3	71267668	71267668	CD
en-wikipedia-org-4107	673	4	.	.	.
en-wikipedia-org-4107	674	1	When	when	WRB
en-wikipedia-org-4107	674	2	oral	oral	JJ
en-wikipedia-org-4107	674	3	formulations	formulation	NNS
en-wikipedia-org-4107	674	4	of	of	IN
en-wikipedia-org-4107	674	5	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	674	6	are	be	VBP
en-wikipedia-org-4107	674	7	used	use	VBN
en-wikipedia-org-4107	674	8	at	at	IN
en-wikipedia-org-4107	674	9	recommended	recommend	VBN
en-wikipedia-org-4107	674	10	doses	dose	NNS
en-wikipedia-org-4107	674	11	and	and	CC
en-wikipedia-org-4107	674	12	frequencies	frequency	NNS
en-wikipedia-org-4107	674	13	,	,	,
en-wikipedia-org-4107	674	14	they	-PRON-	PRP
en-wikipedia-org-4107	674	15	are	be	VBP
en-wikipedia-org-4107	674	16	unlikely	unlikely	JJ
en-wikipedia-org-4107	674	17	to	to	TO
en-wikipedia-org-4107	674	18	yield	yield	VB
en-wikipedia-org-4107	674	19	effects	effect	NNS
en-wikipedia-org-4107	674	20	consistent	consistent	JJ
en-wikipedia-org-4107	674	21	with	with	IN
en-wikipedia-org-4107	674	22	abuse	abuse	NN
en-wikipedia-org-4107	674	23	potential	potential	NN
en-wikipedia-org-4107	674	24	in	in	IN
en-wikipedia-org-4107	674	25	patients	patient	NNS
en-wikipedia-org-4107	674	26	with	with	IN
en-wikipedia-org-4107	674	27	ADHD	ADHD	NNP
en-wikipedia-org-4107	674	28	.	.	.
en-wikipedia-org-4107	675	1	^	^	NNP
en-wikipedia-org-4107	675	2	a	a	DT
en-wikipedia-org-4107	675	3	b	b	NNP
en-wikipedia-org-4107	675	4	c	c	NNP
en-wikipedia-org-4107	675	5	d	d	NNP
en-wikipedia-org-4107	675	6	e	e	NNP
en-wikipedia-org-4107	675	7	f	f	NNP
en-wikipedia-org-4107	675	8	g	g	NNP
en-wikipedia-org-4107	675	9	Broadley	Broadley	NNP
en-wikipedia-org-4107	675	10	KJ	KJ	NNP
en-wikipedia-org-4107	675	11	(	(	-LRB-
en-wikipedia-org-4107	675	12	March	March	NNP
en-wikipedia-org-4107	675	13	2010	2010	CD
en-wikipedia-org-4107	675	14	)	)	-RRB-
en-wikipedia-org-4107	675	15	.	.	.
en-wikipedia-org-4107	676	1	"	"	``
en-wikipedia-org-4107	676	2	The	the	DT
en-wikipedia-org-4107	676	3	vascular	vascular	JJ
en-wikipedia-org-4107	676	4	effects	effect	NNS
en-wikipedia-org-4107	676	5	of	of	IN
en-wikipedia-org-4107	676	6	trace	trace	NN
en-wikipedia-org-4107	676	7	amines	amine	NNS
en-wikipedia-org-4107	676	8	and	and	CC
en-wikipedia-org-4107	676	9	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	676	10	"	"	''
en-wikipedia-org-4107	676	11	.	.	.
en-wikipedia-org-4107	677	1	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	677	2	&	&	CC
en-wikipedia-org-4107	677	3	Therapeutics	Therapeutics	NNP
en-wikipedia-org-4107	677	4	.	.	.
en-wikipedia-org-4107	678	1	125	125	CD
en-wikipedia-org-4107	678	2	(	(	-LRB-
en-wikipedia-org-4107	678	3	3	3	CD
en-wikipedia-org-4107	678	4	)	)	-RRB-
en-wikipedia-org-4107	678	5	:	:	:
en-wikipedia-org-4107	678	6	363–375	363–375	CD
en-wikipedia-org-4107	678	7	.	.	.
en-wikipedia-org-4107	679	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	679	2	/	/	SYM
en-wikipedia-org-4107	679	3	j.pharmthera.2009.11.005	j.pharmthera.2009.11.005	NN
en-wikipedia-org-4107	679	4	.	.	.
en-wikipedia-org-4107	680	1	PMID	PMID	NNP
en-wikipedia-org-4107	680	2	 	  	_SP
en-wikipedia-org-4107	680	3	19948186	19948186	CD
en-wikipedia-org-4107	680	4	.	.	.
en-wikipedia-org-4107	681	1	^	^	NNP
en-wikipedia-org-4107	681	2	a	a	DT
en-wikipedia-org-4107	681	3	b	b	NN
en-wikipedia-org-4107	681	4	c	c	NN
en-wikipedia-org-4107	681	5	d	d	NN
en-wikipedia-org-4107	681	6	"	"	``
en-wikipedia-org-4107	681	7	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	681	8	"	"	''
en-wikipedia-org-4107	681	9	.	.	.
en-wikipedia-org-4107	682	1	European	European	NNP
en-wikipedia-org-4107	682	2	Monitoring	Monitoring	NNP
en-wikipedia-org-4107	682	3	Centre	Centre	NNP
en-wikipedia-org-4107	682	4	for	for	IN
en-wikipedia-org-4107	682	5	Drugs	Drugs	NNP
en-wikipedia-org-4107	682	6	and	and	CC
en-wikipedia-org-4107	682	7	Drug	Drug	NNP
en-wikipedia-org-4107	682	8	Addiction	Addiction	NNP
en-wikipedia-org-4107	682	9	.	.	.
en-wikipedia-org-4107	683	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	683	2	19	19	CD
en-wikipedia-org-4107	683	3	October	October	NNP
en-wikipedia-org-4107	683	4	2013	2013	CD
en-wikipedia-org-4107	683	5	.	.	.
en-wikipedia-org-4107	684	1	^	^	NNP
en-wikipedia-org-4107	684	2	a	a	DT
en-wikipedia-org-4107	684	3	b	b	NNP
en-wikipedia-org-4107	684	4	c	c	NNP
en-wikipedia-org-4107	684	5	d	d	NNP
en-wikipedia-org-4107	684	6	Hagel	Hagel	NNP
en-wikipedia-org-4107	684	7	JM	JM	NNP
en-wikipedia-org-4107	684	8	,	,	,
en-wikipedia-org-4107	684	9	Krizevski	Krizevski	NNP
en-wikipedia-org-4107	684	10	R	R	NNP
en-wikipedia-org-4107	684	11	,	,	,
en-wikipedia-org-4107	684	12	Marsolais	Marsolais	NNP
en-wikipedia-org-4107	684	13	F	F	NNP
en-wikipedia-org-4107	684	14	,	,	,
en-wikipedia-org-4107	684	15	Lewinsohn	Lewinsohn	NNP
en-wikipedia-org-4107	684	16	E	E	NNP
en-wikipedia-org-4107	684	17	,	,	,
en-wikipedia-org-4107	684	18	Facchini	Facchini	NNP
en-wikipedia-org-4107	684	19	PJ	PJ	NNP
en-wikipedia-org-4107	684	20	(	(	-LRB-
en-wikipedia-org-4107	684	21	2012	2012	CD
en-wikipedia-org-4107	684	22	)	)	-RRB-
en-wikipedia-org-4107	684	23	.	.	.
en-wikipedia-org-4107	685	1	"	"	``
en-wikipedia-org-4107	685	2	Biosynthesis	Biosynthesis	NNP
en-wikipedia-org-4107	685	3	of	of	IN
en-wikipedia-org-4107	685	4	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	685	5	analogs	analog	VBZ
en-wikipedia-org-4107	685	6	in	in	IN
en-wikipedia-org-4107	685	7	plants	plant	NNS
en-wikipedia-org-4107	685	8	"	"	''
en-wikipedia-org-4107	685	9	.	.	.
en-wikipedia-org-4107	686	1	Trends	trend	NNS
en-wikipedia-org-4107	686	2	in	in	IN
en-wikipedia-org-4107	686	3	Plant	Plant	NNP
en-wikipedia-org-4107	686	4	Science	Science	NNP
en-wikipedia-org-4107	686	5	.	.	.
en-wikipedia-org-4107	687	1	17	17	CD
en-wikipedia-org-4107	687	2	(	(	-LRB-
en-wikipedia-org-4107	687	3	7	7	CD
en-wikipedia-org-4107	687	4	)	)	-RRB-
en-wikipedia-org-4107	687	5	:	:	:
en-wikipedia-org-4107	687	6	404–412	404–412	CD
en-wikipedia-org-4107	687	7	.	.	.
en-wikipedia-org-4107	688	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	688	2	/	/	SYM
en-wikipedia-org-4107	688	3	j.tplants.2012.03.004	j.tplants.2012.03.004	CD
en-wikipedia-org-4107	688	4	.	.	.
en-wikipedia-org-4107	689	1	PMID	PMID	NNP
en-wikipedia-org-4107	689	2	 	  	_SP
en-wikipedia-org-4107	689	3	22502775	22502775	CD
en-wikipedia-org-4107	689	4	.	.	.
en-wikipedia-org-4107	690	1	Substituted	substitute	VBN
en-wikipedia-org-4107	690	2	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	690	3	,	,	,
en-wikipedia-org-4107	690	4	which	which	WDT
en-wikipedia-org-4107	690	5	are	be	VBP
en-wikipedia-org-4107	690	6	also	also	RB
en-wikipedia-org-4107	690	7	called	call	VBN
en-wikipedia-org-4107	690	8	phenylpropylamino	phenylpropylamino	JJ
en-wikipedia-org-4107	690	9	alkaloids	alkaloid	NNS
en-wikipedia-org-4107	690	10	,	,	,
en-wikipedia-org-4107	690	11	are	be	VBP
en-wikipedia-org-4107	690	12	a	a	DT
en-wikipedia-org-4107	690	13	diverse	diverse	JJ
en-wikipedia-org-4107	690	14	group	group	NN
en-wikipedia-org-4107	690	15	of	of	IN
en-wikipedia-org-4107	690	16	nitrogen	nitrogen	NN
en-wikipedia-org-4107	690	17	-	-	HYPH
en-wikipedia-org-4107	690	18	containing	contain	VBG
en-wikipedia-org-4107	690	19	compounds	compound	NNS
en-wikipedia-org-4107	690	20	that	that	WDT
en-wikipedia-org-4107	690	21	feature	feature	VBP
en-wikipedia-org-4107	690	22	a	a	DT
en-wikipedia-org-4107	690	23	phenethylamine	phenethylamine	NN
en-wikipedia-org-4107	690	24	backbone	backbone	NN
en-wikipedia-org-4107	690	25	with	with	IN
en-wikipedia-org-4107	690	26	a	a	DT
en-wikipedia-org-4107	690	27	methyl	methyl	NN
en-wikipedia-org-4107	690	28	group	group	NN
en-wikipedia-org-4107	690	29	at	at	IN
en-wikipedia-org-4107	690	30	the	the	DT
en-wikipedia-org-4107	690	31	α	α	NNP
en-wikipedia-org-4107	690	32	-	-	HYPH
en-wikipedia-org-4107	690	33	position	position	NN
en-wikipedia-org-4107	690	34	relative	relative	JJ
en-wikipedia-org-4107	690	35	to	to	IN
en-wikipedia-org-4107	690	36	the	the	DT
en-wikipedia-org-4107	690	37	nitrogen	nitrogen	NN
en-wikipedia-org-4107	690	38	(	(	-LRB-
en-wikipedia-org-4107	690	39	Figure	Figure	NNP
en-wikipedia-org-4107	690	40	1	1	CD
en-wikipedia-org-4107	690	41	)	)	-RRB-
en-wikipedia-org-4107	690	42	.	.	.
en-wikipedia-org-4107	691	1	...	...	NFP
en-wikipedia-org-4107	692	1	Beyond	beyond	IN
en-wikipedia-org-4107	692	2	(	(	-LRB-
en-wikipedia-org-4107	692	3	1R,2S)-ephedrine	1r,2s)-ephedrine	CD
en-wikipedia-org-4107	692	4	and	and	CC
en-wikipedia-org-4107	692	5	(	(	-LRB-
en-wikipedia-org-4107	692	6	1S,2S)-pseudoephedrine	1s,2s)-pseudoephedrine	CD
en-wikipedia-org-4107	692	7	,	,	,
en-wikipedia-org-4107	692	8	myriad	myriad	JJ
en-wikipedia-org-4107	692	9	other	other	JJ
en-wikipedia-org-4107	692	10	substituted	substitute	VBN
en-wikipedia-org-4107	692	11	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	692	12	have	have	VBP
en-wikipedia-org-4107	692	13	important	important	JJ
en-wikipedia-org-4107	692	14	pharmaceutical	pharmaceutical	JJ
en-wikipedia-org-4107	692	15	applications	application	NNS
en-wikipedia-org-4107	692	16	.	.	.
en-wikipedia-org-4107	693	1	...	...	:
en-wikipedia-org-4107	693	2	For	for	IN
en-wikipedia-org-4107	693	3	example	example	NN
en-wikipedia-org-4107	693	4	,	,	,
en-wikipedia-org-4107	693	5	(	(	-LRB-
en-wikipedia-org-4107	693	6	S)-amphetamine	S)-amphetamine	NNP
en-wikipedia-org-4107	693	7	(	(	-LRB-
en-wikipedia-org-4107	693	8	Figure	Figure	NNP
en-wikipedia-org-4107	693	9	4b	4b	NNP
en-wikipedia-org-4107	693	10	)	)	-RRB-
en-wikipedia-org-4107	693	11	,	,	,
en-wikipedia-org-4107	693	12	a	a	DT
en-wikipedia-org-4107	693	13	key	key	JJ
en-wikipedia-org-4107	693	14	ingredient	ingredient	NN
en-wikipedia-org-4107	693	15	in	in	IN
en-wikipedia-org-4107	693	16	Adderall	Adderall	NNP
en-wikipedia-org-4107	693	17	and	and	CC
en-wikipedia-org-4107	693	18	Dexedrine	Dexedrine	NNP
en-wikipedia-org-4107	693	19	,	,	,
en-wikipedia-org-4107	693	20	is	be	VBZ
en-wikipedia-org-4107	693	21	used	use	VBN
en-wikipedia-org-4107	693	22	to	to	TO
en-wikipedia-org-4107	693	23	treat	treat	VB
en-wikipedia-org-4107	693	24	attention	attention	NN
en-wikipedia-org-4107	693	25	deficit	deficit	NN
en-wikipedia-org-4107	693	26	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	693	27	disorder	disorder	NN
en-wikipedia-org-4107	693	28	(	(	-LRB-
en-wikipedia-org-4107	693	29	ADHD	ADHD	NNP
en-wikipedia-org-4107	693	30	)	)	-RRB-
en-wikipedia-org-4107	693	31	[	[	-LRB-
en-wikipedia-org-4107	693	32	79	79	CD
en-wikipedia-org-4107	693	33	]	]	-RRB-
en-wikipedia-org-4107	693	34	.	.	.
en-wikipedia-org-4107	694	1	...	...	NFP
en-wikipedia-org-4107	694	2	[	[	-LRB-
en-wikipedia-org-4107	694	3	Figure	figure	NN
en-wikipedia-org-4107	694	4	4](b	4](b	NN
en-wikipedia-org-4107	694	5	)	)	-RRB-
en-wikipedia-org-4107	694	6	Examples	example	NNS
en-wikipedia-org-4107	694	7	of	of	IN
en-wikipedia-org-4107	694	8	synthetic	synthetic	JJ
en-wikipedia-org-4107	694	9	,	,	,
en-wikipedia-org-4107	694	10	pharmaceutically	pharmaceutically	RB
en-wikipedia-org-4107	694	11	important	important	JJ
en-wikipedia-org-4107	694	12	substituted	substitute	VBN
en-wikipedia-org-4107	694	13	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	694	14	.	.	.
en-wikipedia-org-4107	695	1	^	^	NNP
en-wikipedia-org-4107	695	2	a	a	DT
en-wikipedia-org-4107	695	3	b	b	NN
en-wikipedia-org-4107	695	4	Bett	Bett	NNP
en-wikipedia-org-4107	695	5	WR	WR	NNP
en-wikipedia-org-4107	695	6	(	(	-LRB-
en-wikipedia-org-4107	695	7	August	August	NNP
en-wikipedia-org-4107	695	8	1946	1946	CD
en-wikipedia-org-4107	695	9	)	)	-RRB-
en-wikipedia-org-4107	695	10	.	.	.
en-wikipedia-org-4107	696	1	"	"	``
en-wikipedia-org-4107	696	2	Benzedrine	benzedrine	JJ
en-wikipedia-org-4107	696	3	sulphate	sulphate	NN
en-wikipedia-org-4107	696	4	in	in	IN
en-wikipedia-org-4107	696	5	clinical	clinical	JJ
en-wikipedia-org-4107	696	6	medicine	medicine	NN
en-wikipedia-org-4107	696	7	;	;	:
en-wikipedia-org-4107	696	8	a	a	DT
en-wikipedia-org-4107	696	9	survey	survey	NN
en-wikipedia-org-4107	696	10	of	of	IN
en-wikipedia-org-4107	696	11	the	the	DT
en-wikipedia-org-4107	696	12	literature	literature	NN
en-wikipedia-org-4107	696	13	"	"	''
en-wikipedia-org-4107	696	14	.	.	.
en-wikipedia-org-4107	697	1	Postgraduate	Postgraduate	NNP
en-wikipedia-org-4107	697	2	Medical	Medical	NNP
en-wikipedia-org-4107	697	3	Journal	Journal	NNP
en-wikipedia-org-4107	697	4	.	.	.
en-wikipedia-org-4107	698	1	22	22	CD
en-wikipedia-org-4107	698	2	(	(	-LRB-
en-wikipedia-org-4107	698	3	250	250	CD
en-wikipedia-org-4107	698	4	)	)	-RRB-
en-wikipedia-org-4107	698	5	:	:	:
en-wikipedia-org-4107	698	6	205–218	205–218	CD
en-wikipedia-org-4107	698	7	.	.	.
en-wikipedia-org-4107	699	1	doi:10.1136	doi:10.1136	NNP
en-wikipedia-org-4107	699	2	/	/	SYM
en-wikipedia-org-4107	699	3	pgmj.22.250.205	pgmj.22.250.205	NN
en-wikipedia-org-4107	699	4	.	.	.
en-wikipedia-org-4107	700	1	PMC	PMC	NNP
en-wikipedia-org-4107	700	2	 	  	_SP
en-wikipedia-org-4107	700	3	2478360	2478360	CD
en-wikipedia-org-4107	700	4	.	.	.
en-wikipedia-org-4107	701	1	PMID	PMID	NNP
en-wikipedia-org-4107	701	2	 	  	_SP
en-wikipedia-org-4107	701	3	20997404	20997404	CD
en-wikipedia-org-4107	701	4	.	.	.
en-wikipedia-org-4107	702	1	^	^	NNP
en-wikipedia-org-4107	702	2	a	a	DT
en-wikipedia-org-4107	702	3	b	b	NN
en-wikipedia-org-4107	702	4	Carvalho	Carvalho	NNP
en-wikipedia-org-4107	702	5	M	M	NNP
en-wikipedia-org-4107	702	6	,	,	,
en-wikipedia-org-4107	702	7	Carmo	Carmo	NNP
en-wikipedia-org-4107	702	8	H	H	NNP
en-wikipedia-org-4107	702	9	,	,	,
en-wikipedia-org-4107	702	10	Costa	Costa	NNP
en-wikipedia-org-4107	702	11	VM	VM	NNP
en-wikipedia-org-4107	702	12	,	,	,
en-wikipedia-org-4107	702	13	Capela	Capela	NNP
en-wikipedia-org-4107	702	14	JP	JP	NNP
en-wikipedia-org-4107	702	15	,	,	,
en-wikipedia-org-4107	702	16	Pontes	Pontes	NNPS
en-wikipedia-org-4107	702	17	H	H	NNP
en-wikipedia-org-4107	702	18	,	,	,
en-wikipedia-org-4107	702	19	Remião	Remião	NNP
en-wikipedia-org-4107	702	20	F	F	NNP
en-wikipedia-org-4107	702	21	,	,	,
en-wikipedia-org-4107	702	22	Carvalho	Carvalho	NNP
en-wikipedia-org-4107	702	23	F	F	NNP
en-wikipedia-org-4107	702	24	,	,	,
en-wikipedia-org-4107	702	25	Bastos	Bastos	NNP
en-wikipedia-org-4107	702	26	Mde	Mde	NNP
en-wikipedia-org-4107	702	27	L	L	NNP
en-wikipedia-org-4107	702	28	(	(	-LRB-
en-wikipedia-org-4107	702	29	August	August	NNP
en-wikipedia-org-4107	702	30	2012	2012	CD
en-wikipedia-org-4107	702	31	)	)	-RRB-
en-wikipedia-org-4107	702	32	.	.	.
en-wikipedia-org-4107	703	1	"	"	``
en-wikipedia-org-4107	703	2	Toxicity	Toxicity	NNP
en-wikipedia-org-4107	703	3	of	of	IN
en-wikipedia-org-4107	703	4	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	703	5	:	:	:
en-wikipedia-org-4107	703	6	an	an	DT
en-wikipedia-org-4107	703	7	update	update	NN
en-wikipedia-org-4107	703	8	"	"	''
en-wikipedia-org-4107	703	9	.	.	.
en-wikipedia-org-4107	704	1	Archives	archive	NNS
en-wikipedia-org-4107	704	2	of	of	IN
en-wikipedia-org-4107	704	3	Toxicology	Toxicology	NNP
en-wikipedia-org-4107	704	4	.	.	.
en-wikipedia-org-4107	705	1	86	86	CD
en-wikipedia-org-4107	705	2	(	(	-LRB-
en-wikipedia-org-4107	705	3	8)	8)	CD
en-wikipedia-org-4107	705	4	:	:	:
en-wikipedia-org-4107	705	5	1167–1231	1167–1231	CD
en-wikipedia-org-4107	705	6	.	.	.
en-wikipedia-org-4107	706	1	doi:10.1007	doi:10.1007	NNP
en-wikipedia-org-4107	706	2	/	/	SYM
en-wikipedia-org-4107	706	3	s00204	s00204	NNP
en-wikipedia-org-4107	706	4	-	-	HYPH
en-wikipedia-org-4107	706	5	012	012	CD
en-wikipedia-org-4107	706	6	-	-	HYPH
en-wikipedia-org-4107	706	7	0815	0815	CD
en-wikipedia-org-4107	706	8	-	-	HYPH
en-wikipedia-org-4107	706	9	5	5	CD
en-wikipedia-org-4107	706	10	.	.	.
en-wikipedia-org-4107	707	1	PMID	PMID	NNP
en-wikipedia-org-4107	707	2	 	  	_SP
en-wikipedia-org-4107	707	3	22392347	22392347	CD
en-wikipedia-org-4107	707	4	.	.	.
en-wikipedia-org-4107	708	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	708	2	 	  	_SP
en-wikipedia-org-4107	708	3	2873101	2873101	CD
en-wikipedia-org-4107	708	4	.	.	.
en-wikipedia-org-4107	709	1	^	^	NN
en-wikipedia-org-4107	709	2	Berman	Berman	NNP
en-wikipedia-org-4107	709	3	S	S	NNP
en-wikipedia-org-4107	709	4	,	,	,
en-wikipedia-org-4107	709	5	O'Neill	O'Neill	NNP
en-wikipedia-org-4107	709	6	J	J	NNP
en-wikipedia-org-4107	709	7	,	,	,
en-wikipedia-org-4107	709	8	Fears	Fears	NNP
en-wikipedia-org-4107	709	9	S	S	NNP
en-wikipedia-org-4107	709	10	,	,	,
en-wikipedia-org-4107	709	11	Bartzokis	Bartzokis	NNP
en-wikipedia-org-4107	709	12	G	G	NNP
en-wikipedia-org-4107	709	13	,	,	,
en-wikipedia-org-4107	709	14	London	London	NNP
en-wikipedia-org-4107	709	15	ED	ED	NNP
en-wikipedia-org-4107	709	16	(	(	-LRB-
en-wikipedia-org-4107	709	17	October	October	NNP
en-wikipedia-org-4107	709	18	2008	2008	CD
en-wikipedia-org-4107	709	19	)	)	-RRB-
en-wikipedia-org-4107	709	20	.	.	.
en-wikipedia-org-4107	710	1	"	"	``
en-wikipedia-org-4107	710	2	Abuse	abuse	NN
en-wikipedia-org-4107	710	3	of	of	IN
en-wikipedia-org-4107	710	4	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	710	5	and	and	CC
en-wikipedia-org-4107	710	6	structural	structural	JJ
en-wikipedia-org-4107	710	7	abnormalities	abnormality	NNS
en-wikipedia-org-4107	710	8	in	in	IN
en-wikipedia-org-4107	710	9	the	the	DT
en-wikipedia-org-4107	710	10	brain	brain	NN
en-wikipedia-org-4107	710	11	"	"	''
en-wikipedia-org-4107	710	12	.	.	.
en-wikipedia-org-4107	711	1	Annals	annal	NNS
en-wikipedia-org-4107	711	2	of	of	IN
en-wikipedia-org-4107	711	3	the	the	DT
en-wikipedia-org-4107	711	4	New	New	NNP
en-wikipedia-org-4107	711	5	York	York	NNP
en-wikipedia-org-4107	711	6	Academy	Academy	NNP
en-wikipedia-org-4107	711	7	of	of	IN
en-wikipedia-org-4107	711	8	Sciences	Sciences	NNPS
en-wikipedia-org-4107	711	9	.	.	.
en-wikipedia-org-4107	712	1	1141	1141	CD
en-wikipedia-org-4107	712	2	(	(	-LRB-
en-wikipedia-org-4107	712	3	1	1	CD
en-wikipedia-org-4107	712	4	)	)	-RRB-
en-wikipedia-org-4107	712	5	:	:	:
en-wikipedia-org-4107	712	6	195–220	195–220	CD
en-wikipedia-org-4107	712	7	.	.	.
en-wikipedia-org-4107	713	1	doi:10.1196	doi:10.1196	NNP
en-wikipedia-org-4107	713	2	/	/	SYM
en-wikipedia-org-4107	713	3	annals.1441.031	annals.1441.031	ADD
en-wikipedia-org-4107	713	4	.	.	.
en-wikipedia-org-4107	714	1	PMC	PMC	NNP
en-wikipedia-org-4107	714	2	 	  	_SP
en-wikipedia-org-4107	714	3	2769923	2769923	CD
en-wikipedia-org-4107	714	4	.	.	.
en-wikipedia-org-4107	715	1	PMID	PMID	NNP
en-wikipedia-org-4107	715	2	 	  	_SP
en-wikipedia-org-4107	715	3	18991959	18991959	CD
en-wikipedia-org-4107	715	4	.	.	.
en-wikipedia-org-4107	716	1	^	^	NNP
en-wikipedia-org-4107	716	2	a	a	DT
en-wikipedia-org-4107	716	3	b	b	NNP
en-wikipedia-org-4107	716	4	Hart	Hart	NNP
en-wikipedia-org-4107	716	5	H	H	NNP
en-wikipedia-org-4107	716	6	,	,	,
en-wikipedia-org-4107	716	7	Radua	Radua	NNP
en-wikipedia-org-4107	716	8	J	J	NNP
en-wikipedia-org-4107	716	9	,	,	,
en-wikipedia-org-4107	716	10	Nakao	Nakao	NNP
en-wikipedia-org-4107	716	11	T	T	NNP
en-wikipedia-org-4107	716	12	,	,	,
en-wikipedia-org-4107	716	13	Mataix	Mataix	NNP
en-wikipedia-org-4107	716	14	-	-	HYPH
en-wikipedia-org-4107	716	15	Cols	Cols	NNP
en-wikipedia-org-4107	716	16	D	D	NNP
en-wikipedia-org-4107	716	17	,	,	,
en-wikipedia-org-4107	716	18	Rubia	Rubia	NNP
en-wikipedia-org-4107	716	19	K	K	NNP
en-wikipedia-org-4107	716	20	(	(	-LRB-
en-wikipedia-org-4107	716	21	February	February	NNP
en-wikipedia-org-4107	716	22	2013	2013	CD
en-wikipedia-org-4107	716	23	)	)	-RRB-
en-wikipedia-org-4107	716	24	.	.	.
en-wikipedia-org-4107	717	1	"	"	``
en-wikipedia-org-4107	717	2	Meta	meta	JJ
en-wikipedia-org-4107	717	3	-	-	HYPH
en-wikipedia-org-4107	717	4	analysis	analysis	NN
en-wikipedia-org-4107	717	5	of	of	IN
en-wikipedia-org-4107	717	6	functional	functional	JJ
en-wikipedia-org-4107	717	7	magnetic	magnetic	JJ
en-wikipedia-org-4107	717	8	resonance	resonance	NN
en-wikipedia-org-4107	717	9	imaging	imaging	NN
en-wikipedia-org-4107	717	10	studies	study	NNS
en-wikipedia-org-4107	717	11	of	of	IN
en-wikipedia-org-4107	717	12	inhibition	inhibition	NN
en-wikipedia-org-4107	717	13	and	and	CC
en-wikipedia-org-4107	717	14	attention	attention	NN
en-wikipedia-org-4107	717	15	in	in	IN
en-wikipedia-org-4107	717	16	attention	attention	NN
en-wikipedia-org-4107	717	17	-	-	HYPH
en-wikipedia-org-4107	717	18	deficit	deficit	NN
en-wikipedia-org-4107	717	19	/	/	SYM
en-wikipedia-org-4107	717	20	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	717	21	disorder	disorder	NN
en-wikipedia-org-4107	717	22	:	:	:
en-wikipedia-org-4107	717	23	exploring	explore	VBG
en-wikipedia-org-4107	717	24	task	task	NN
en-wikipedia-org-4107	717	25	-	-	HYPH
en-wikipedia-org-4107	717	26	specific	specific	JJ
en-wikipedia-org-4107	717	27	,	,	,
en-wikipedia-org-4107	717	28	stimulant	stimulant	JJ
en-wikipedia-org-4107	717	29	medication	medication	NN
en-wikipedia-org-4107	717	30	,	,	,
en-wikipedia-org-4107	717	31	and	and	CC
en-wikipedia-org-4107	717	32	age	age	NN
en-wikipedia-org-4107	717	33	effects	effect	NNS
en-wikipedia-org-4107	717	34	"	"	''
en-wikipedia-org-4107	717	35	.	.	.
en-wikipedia-org-4107	718	1	JAMA	JAMA	NNP
en-wikipedia-org-4107	718	2	Psychiatry	Psychiatry	NNP
en-wikipedia-org-4107	718	3	.	.	.
en-wikipedia-org-4107	719	1	70	70	CD
en-wikipedia-org-4107	719	2	(	(	-LRB-
en-wikipedia-org-4107	719	3	2	2	CD
en-wikipedia-org-4107	719	4	)	)	-RRB-
en-wikipedia-org-4107	719	5	:	:	:
en-wikipedia-org-4107	719	6	185–198	185–198	CD
en-wikipedia-org-4107	719	7	.	.	.
en-wikipedia-org-4107	720	1	doi:10.1001	doi:10.1001	NNP
en-wikipedia-org-4107	720	2	/	/	SYM
en-wikipedia-org-4107	720	3	jamapsychiatry.2013.277	jamapsychiatry.2013.277	NN
en-wikipedia-org-4107	720	4	.	.	.
en-wikipedia-org-4107	721	1	PMID	PMID	NNP
en-wikipedia-org-4107	721	2	 	  	_SP
en-wikipedia-org-4107	721	3	23247506	23247506	CD
en-wikipedia-org-4107	721	4	.	.	.
en-wikipedia-org-4107	722	1	^	^	NNP
en-wikipedia-org-4107	722	2	a	a	DT
en-wikipedia-org-4107	722	3	b	b	NNP
en-wikipedia-org-4107	722	4	Spencer	Spencer	NNP
en-wikipedia-org-4107	722	5	TJ	TJ	NNP
en-wikipedia-org-4107	722	6	,	,	,
en-wikipedia-org-4107	722	7	Brown	Brown	NNP
en-wikipedia-org-4107	722	8	A	A	NNP
en-wikipedia-org-4107	722	9	,	,	,
en-wikipedia-org-4107	722	10	Seidman	Seidman	NNP
en-wikipedia-org-4107	722	11	LJ	LJ	NNP
en-wikipedia-org-4107	722	12	,	,	,
en-wikipedia-org-4107	722	13	Valera	Valera	NNP
en-wikipedia-org-4107	722	14	EM	EM	NNP
en-wikipedia-org-4107	722	15	,	,	,
en-wikipedia-org-4107	722	16	Makris	Makris	NNP
en-wikipedia-org-4107	722	17	N	N	NNP
en-wikipedia-org-4107	722	18	,	,	,
en-wikipedia-org-4107	722	19	Lomedico	Lomedico	NNP
en-wikipedia-org-4107	722	20	A	A	NNP
en-wikipedia-org-4107	722	21	,	,	,
en-wikipedia-org-4107	722	22	Faraone	Faraone	NNP
en-wikipedia-org-4107	722	23	SV	SV	NNP
en-wikipedia-org-4107	722	24	,	,	,
en-wikipedia-org-4107	722	25	Biederman	Biederman	NNP
en-wikipedia-org-4107	722	26	J	J	NNP
en-wikipedia-org-4107	722	27	(	(	-LRB-
en-wikipedia-org-4107	722	28	September	September	NNP
en-wikipedia-org-4107	722	29	2013	2013	CD
en-wikipedia-org-4107	722	30	)	)	-RRB-
en-wikipedia-org-4107	722	31	.	.	.
en-wikipedia-org-4107	723	1	"	"	``
en-wikipedia-org-4107	723	2	Effect	effect	NN
en-wikipedia-org-4107	723	3	of	of	IN
en-wikipedia-org-4107	723	4	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	723	5	on	on	IN
en-wikipedia-org-4107	723	6	brain	brain	NN
en-wikipedia-org-4107	723	7	structure	structure	NN
en-wikipedia-org-4107	723	8	and	and	CC
en-wikipedia-org-4107	723	9	function	function	NN
en-wikipedia-org-4107	723	10	in	in	IN
en-wikipedia-org-4107	723	11	ADHD	ADHD	NNP
en-wikipedia-org-4107	723	12	:	:	:
en-wikipedia-org-4107	723	13	a	a	DT
en-wikipedia-org-4107	723	14	qualitative	qualitative	JJ
en-wikipedia-org-4107	723	15	literature	literature	NN
en-wikipedia-org-4107	723	16	review	review	NN
en-wikipedia-org-4107	723	17	of	of	IN
en-wikipedia-org-4107	723	18	magnetic	magnetic	JJ
en-wikipedia-org-4107	723	19	resonance	resonance	NN
en-wikipedia-org-4107	723	20	imaging	imaging	NN
en-wikipedia-org-4107	723	21	-	-	HYPH
en-wikipedia-org-4107	723	22	based	base	VBN
en-wikipedia-org-4107	723	23	neuroimaging	neuroimage	VBG
en-wikipedia-org-4107	723	24	studies	study	NNS
en-wikipedia-org-4107	723	25	"	"	''
en-wikipedia-org-4107	723	26	.	.	.
en-wikipedia-org-4107	724	1	The	the	DT
en-wikipedia-org-4107	724	2	Journal	Journal	NNP
en-wikipedia-org-4107	724	3	of	of	IN
en-wikipedia-org-4107	724	4	Clinical	Clinical	NNP
en-wikipedia-org-4107	724	5	Psychiatry	Psychiatry	NNP
en-wikipedia-org-4107	724	6	.	.	.
en-wikipedia-org-4107	725	1	74	74	CD
en-wikipedia-org-4107	725	2	(	(	-LRB-
en-wikipedia-org-4107	725	3	9	9	CD
en-wikipedia-org-4107	725	4	)	)	-RRB-
en-wikipedia-org-4107	725	5	:	:	:
en-wikipedia-org-4107	725	6	902–917	902–917	CD
en-wikipedia-org-4107	725	7	.	.	.
en-wikipedia-org-4107	726	1	doi:10.4088	doi:10.4088	NNP
en-wikipedia-org-4107	726	2	/	/	SYM
en-wikipedia-org-4107	726	3	JCP.12r08287	JCP.12r08287	NNP
en-wikipedia-org-4107	726	4	.	.	.
en-wikipedia-org-4107	727	1	PMC	PMC	NNP
en-wikipedia-org-4107	727	2	 	  	_SP
en-wikipedia-org-4107	727	3	3801446	3801446	CD
en-wikipedia-org-4107	727	4	.	.	.
en-wikipedia-org-4107	728	1	PMID	PMID	NNP
en-wikipedia-org-4107	728	2	 	  	_SP
en-wikipedia-org-4107	728	3	24107764	24107764	CD
en-wikipedia-org-4107	728	4	.	.	.
en-wikipedia-org-4107	729	1	^	^	NNP
en-wikipedia-org-4107	729	2	a	a	DT
en-wikipedia-org-4107	729	3	b	b	NN
en-wikipedia-org-4107	729	4	Frodl	Frodl	NNP
en-wikipedia-org-4107	729	5	T	T	NNP
en-wikipedia-org-4107	729	6	,	,	,
en-wikipedia-org-4107	729	7	Skokauskas	Skokauskas	NNP
en-wikipedia-org-4107	729	8	N	N	NNP
en-wikipedia-org-4107	729	9	(	(	-LRB-
en-wikipedia-org-4107	729	10	February	February	NNP
en-wikipedia-org-4107	729	11	2012	2012	CD
en-wikipedia-org-4107	729	12	)	)	-RRB-
en-wikipedia-org-4107	729	13	.	.	.
en-wikipedia-org-4107	730	1	"	"	``
en-wikipedia-org-4107	730	2	Meta	meta	JJ
en-wikipedia-org-4107	730	3	-	-	HYPH
en-wikipedia-org-4107	730	4	analysis	analysis	NN
en-wikipedia-org-4107	730	5	of	of	IN
en-wikipedia-org-4107	730	6	structural	structural	JJ
en-wikipedia-org-4107	730	7	MRI	MRI	NNP
en-wikipedia-org-4107	730	8	studies	study	NNS
en-wikipedia-org-4107	730	9	in	in	IN
en-wikipedia-org-4107	730	10	children	child	NNS
en-wikipedia-org-4107	730	11	and	and	CC
en-wikipedia-org-4107	730	12	adults	adult	NNS
en-wikipedia-org-4107	730	13	with	with	IN
en-wikipedia-org-4107	730	14	attention	attention	NN
en-wikipedia-org-4107	730	15	deficit	deficit	NN
en-wikipedia-org-4107	730	16	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	730	17	disorder	disorder	NN
en-wikipedia-org-4107	730	18	indicates	indicate	VBZ
en-wikipedia-org-4107	730	19	treatment	treatment	NN
en-wikipedia-org-4107	730	20	effects	effect	NNS
en-wikipedia-org-4107	730	21	"	"	''
en-wikipedia-org-4107	730	22	.	.	.
en-wikipedia-org-4107	731	1	Acta	Acta	NNP
en-wikipedia-org-4107	731	2	Psychiatrica	Psychiatrica	NNP
en-wikipedia-org-4107	731	3	Scandinavica	Scandinavica	NNP
en-wikipedia-org-4107	731	4	.	.	.
en-wikipedia-org-4107	732	1	125	125	CD
en-wikipedia-org-4107	732	2	(	(	-LRB-
en-wikipedia-org-4107	732	3	2	2	CD
en-wikipedia-org-4107	732	4	)	)	-RRB-
en-wikipedia-org-4107	732	5	:	:	:
en-wikipedia-org-4107	732	6	114–126	114–126	CD
en-wikipedia-org-4107	732	7	.	.	.
en-wikipedia-org-4107	733	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-4107	733	2	/	/	SYM
en-wikipedia-org-4107	733	3	j.1600	j.1600	NNP
en-wikipedia-org-4107	733	4	-	-	HYPH
en-wikipedia-org-4107	733	5	0447.2011.01786.x	0447.2011.01786.x	NNP
en-wikipedia-org-4107	733	6	.	.	.
en-wikipedia-org-4107	734	1	PMID	PMID	NNP
en-wikipedia-org-4107	734	2	 	  	_SP
en-wikipedia-org-4107	734	3	22118249	22118249	CD
en-wikipedia-org-4107	734	4	.	.	.
en-wikipedia-org-4107	735	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	735	2	 	  	_SP
en-wikipedia-org-4107	735	3	25954331	25954331	CD
en-wikipedia-org-4107	735	4	.	.	.
en-wikipedia-org-4107	736	1	Basal	Basal	NNP
en-wikipedia-org-4107	736	2	ganglia	ganglia	NNP
en-wikipedia-org-4107	736	3	regions	region	NNS
en-wikipedia-org-4107	736	4	like	like	IN
en-wikipedia-org-4107	736	5	the	the	DT
en-wikipedia-org-4107	736	6	right	right	NNP
en-wikipedia-org-4107	736	7	globus	globus	NNP
en-wikipedia-org-4107	736	8	pallidus	pallidus	NNP
en-wikipedia-org-4107	736	9	,	,	,
en-wikipedia-org-4107	736	10	the	the	DT
en-wikipedia-org-4107	736	11	right	right	JJ
en-wikipedia-org-4107	736	12	putamen	putamen	NN
en-wikipedia-org-4107	736	13	,	,	,
en-wikipedia-org-4107	736	14	and	and	CC
en-wikipedia-org-4107	736	15	the	the	DT
en-wikipedia-org-4107	736	16	nucleus	nucleus	NNP
en-wikipedia-org-4107	736	17	caudatus	caudatus	NNP
en-wikipedia-org-4107	736	18	are	be	VBP
en-wikipedia-org-4107	736	19	structurally	structurally	RB
en-wikipedia-org-4107	736	20	affected	affect	VBN
en-wikipedia-org-4107	736	21	in	in	IN
en-wikipedia-org-4107	736	22	children	child	NNS
en-wikipedia-org-4107	736	23	with	with	IN
en-wikipedia-org-4107	736	24	ADHD	ADHD	NNP
en-wikipedia-org-4107	736	25	.	.	.
en-wikipedia-org-4107	737	1	These	these	DT
en-wikipedia-org-4107	737	2	changes	change	NNS
en-wikipedia-org-4107	737	3	and	and	CC
en-wikipedia-org-4107	737	4	alterations	alteration	NNS
en-wikipedia-org-4107	737	5	in	in	IN
en-wikipedia-org-4107	737	6	limbic	limbic	JJ
en-wikipedia-org-4107	737	7	regions	region	NNS
en-wikipedia-org-4107	737	8	like	like	IN
en-wikipedia-org-4107	737	9	ACC	ACC	NNP
en-wikipedia-org-4107	737	10	and	and	CC
en-wikipedia-org-4107	737	11	amygdala	amygdala	NNP
en-wikipedia-org-4107	737	12	are	be	VBP
en-wikipedia-org-4107	737	13	more	more	RBR
en-wikipedia-org-4107	737	14	pronounced	pronounced	JJ
en-wikipedia-org-4107	737	15	in	in	IN
en-wikipedia-org-4107	737	16	non	non	JJ
en-wikipedia-org-4107	737	17	-	-	JJ
en-wikipedia-org-4107	737	18	treated	treated	JJ
en-wikipedia-org-4107	737	19	populations	population	NNS
en-wikipedia-org-4107	737	20	and	and	CC
en-wikipedia-org-4107	737	21	seem	seem	VBP
en-wikipedia-org-4107	737	22	to	to	TO
en-wikipedia-org-4107	737	23	diminish	diminish	VB
en-wikipedia-org-4107	737	24	over	over	IN
en-wikipedia-org-4107	737	25	time	time	NN
en-wikipedia-org-4107	737	26	from	from	IN
en-wikipedia-org-4107	737	27	child	child	NN
en-wikipedia-org-4107	737	28	to	to	IN
en-wikipedia-org-4107	737	29	adulthood	adulthood	NN
en-wikipedia-org-4107	737	30	.	.	.
en-wikipedia-org-4107	738	1	Treatment	treatment	NN
en-wikipedia-org-4107	738	2	seems	seem	VBZ
en-wikipedia-org-4107	738	3	to	to	TO
en-wikipedia-org-4107	738	4	have	have	VB
en-wikipedia-org-4107	738	5	positive	positive	JJ
en-wikipedia-org-4107	738	6	effects	effect	NNS
en-wikipedia-org-4107	738	7	on	on	IN
en-wikipedia-org-4107	738	8	brain	brain	NN
en-wikipedia-org-4107	738	9	structure	structure	NN
en-wikipedia-org-4107	738	10	.	.	.
en-wikipedia-org-4107	739	1	^	^	NNP
en-wikipedia-org-4107	739	2	a	a	DT
en-wikipedia-org-4107	739	3	b	b	NN
en-wikipedia-org-4107	739	4	c	c	NN
en-wikipedia-org-4107	739	5	d	d	NN
en-wikipedia-org-4107	739	6	Millichap	Millichap	NNP
en-wikipedia-org-4107	739	7	JG	JG	NNP
en-wikipedia-org-4107	739	8	(	(	-LRB-
en-wikipedia-org-4107	739	9	2010	2010	CD
en-wikipedia-org-4107	739	10	)	)	-RRB-
en-wikipedia-org-4107	739	11	.	.	.
en-wikipedia-org-4107	740	1	"	"	``
en-wikipedia-org-4107	740	2	Chapter	chapter	NN
en-wikipedia-org-4107	740	3	9	9	CD
en-wikipedia-org-4107	740	4	:	:	:
en-wikipedia-org-4107	740	5	Medications	medication	NNS
en-wikipedia-org-4107	740	6	for	for	IN
en-wikipedia-org-4107	740	7	ADHD	ADHD	NNP
en-wikipedia-org-4107	740	8	"	"	''
en-wikipedia-org-4107	740	9	.	.	.
en-wikipedia-org-4107	741	1	In	in	IN
en-wikipedia-org-4107	741	2	Millichap	Millichap	NNP
en-wikipedia-org-4107	741	3	JG	JG	NNP
en-wikipedia-org-4107	741	4	(	(	-LRB-
en-wikipedia-org-4107	741	5	ed	ed	NNP
en-wikipedia-org-4107	741	6	.	.	.
en-wikipedia-org-4107	741	7	)	)	-RRB-
en-wikipedia-org-4107	741	8	.	.	.
en-wikipedia-org-4107	742	1	Attention	attention	NN
en-wikipedia-org-4107	742	2	Deficit	Deficit	NNP
en-wikipedia-org-4107	742	3	Hyperactivity	Hyperactivity	NNP
en-wikipedia-org-4107	742	4	Disorder	Disorder	NNP
en-wikipedia-org-4107	742	5	Handbook	Handbook	NNP
en-wikipedia-org-4107	742	6	:	:	:
en-wikipedia-org-4107	742	7	A	a	DT
en-wikipedia-org-4107	742	8	Physician	Physician	NNP
en-wikipedia-org-4107	742	9	's	's	POS
en-wikipedia-org-4107	742	10	Guide	Guide	NNP
en-wikipedia-org-4107	742	11	to	to	IN
en-wikipedia-org-4107	742	12	ADHD	ADHD	NNP
en-wikipedia-org-4107	742	13	(	(	-LRB-
en-wikipedia-org-4107	742	14	2nd	2nd	NNP
en-wikipedia-org-4107	742	15	ed	ed	NNP
en-wikipedia-org-4107	742	16	.	.	.
en-wikipedia-org-4107	742	17	)	)	-RRB-
en-wikipedia-org-4107	742	18	.	.	.
en-wikipedia-org-4107	743	1	New	New	NNP
en-wikipedia-org-4107	743	2	York	York	NNP
en-wikipedia-org-4107	743	3	,	,	,
en-wikipedia-org-4107	743	4	USA	USA	NNP
en-wikipedia-org-4107	743	5	:	:	:
en-wikipedia-org-4107	743	6	Springer	Springer	NNP
en-wikipedia-org-4107	743	7	.	.	.
en-wikipedia-org-4107	744	1	pp	pp	NNP
en-wikipedia-org-4107	744	2	.	.	.
en-wikipedia-org-4107	745	1	121–123	121–123	CD
en-wikipedia-org-4107	745	2	,	,	,
en-wikipedia-org-4107	745	3	125–127	125–127	CD
en-wikipedia-org-4107	745	4	.	.	.
en-wikipedia-org-4107	746	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	746	2	 	  	_SP
en-wikipedia-org-4107	746	3	9781441913968	9781441913968	CD
en-wikipedia-org-4107	746	4	.	.	.
en-wikipedia-org-4107	747	1	Ongoing	ongoing	JJ
en-wikipedia-org-4107	747	2	research	research	NN
en-wikipedia-org-4107	747	3	has	have	VBZ
en-wikipedia-org-4107	747	4	provided	provide	VBN
en-wikipedia-org-4107	747	5	answers	answer	NNS
en-wikipedia-org-4107	747	6	to	to	IN
en-wikipedia-org-4107	747	7	many	many	JJ
en-wikipedia-org-4107	747	8	of	of	IN
en-wikipedia-org-4107	747	9	the	the	DT
en-wikipedia-org-4107	747	10	parents	parent	NNS
en-wikipedia-org-4107	747	11	'	'	POS
en-wikipedia-org-4107	747	12	concerns	concern	NNS
en-wikipedia-org-4107	747	13	,	,	,
en-wikipedia-org-4107	747	14	and	and	CC
en-wikipedia-org-4107	747	15	has	have	VBZ
en-wikipedia-org-4107	747	16	confirmed	confirm	VBN
en-wikipedia-org-4107	747	17	the	the	DT
en-wikipedia-org-4107	747	18	effectiveness	effectiveness	NN
en-wikipedia-org-4107	747	19	and	and	CC
en-wikipedia-org-4107	747	20	safety	safety	NN
en-wikipedia-org-4107	747	21	of	of	IN
en-wikipedia-org-4107	747	22	the	the	DT
en-wikipedia-org-4107	747	23	long	long	JJ
en-wikipedia-org-4107	747	24	-	-	HYPH
en-wikipedia-org-4107	747	25	term	term	NN
en-wikipedia-org-4107	747	26	use	use	NN
en-wikipedia-org-4107	747	27	of	of	IN
en-wikipedia-org-4107	747	28	medication	medication	NN
en-wikipedia-org-4107	747	29	.	.	.
en-wikipedia-org-4107	748	1	^	^	NNP
en-wikipedia-org-4107	748	2	a	a	DT
en-wikipedia-org-4107	748	3	b	b	NNP
en-wikipedia-org-4107	748	4	c	c	NN
en-wikipedia-org-4107	748	5	d	d	NN
en-wikipedia-org-4107	748	6	e	e	NN
en-wikipedia-org-4107	748	7	Arnold	Arnold	NNP
en-wikipedia-org-4107	748	8	LE	LE	NNP
en-wikipedia-org-4107	748	9	,	,	,
en-wikipedia-org-4107	748	10	Hodgkins	Hodgkins	NNP
en-wikipedia-org-4107	748	11	P	P	NNP
en-wikipedia-org-4107	748	12	,	,	,
en-wikipedia-org-4107	748	13	Caci	Caci	NNP
en-wikipedia-org-4107	748	14	H	H	NNP
en-wikipedia-org-4107	748	15	,	,	,
en-wikipedia-org-4107	748	16	Kahle	Kahle	NNP
en-wikipedia-org-4107	748	17	J	J	NNP
en-wikipedia-org-4107	748	18	,	,	,
en-wikipedia-org-4107	748	19	Young	Young	NNP
en-wikipedia-org-4107	748	20	S	S	NNP
en-wikipedia-org-4107	748	21	(	(	-LRB-
en-wikipedia-org-4107	748	22	February	February	NNP
en-wikipedia-org-4107	748	23	2015	2015	CD
en-wikipedia-org-4107	748	24	)	)	-RRB-
en-wikipedia-org-4107	748	25	.	.	.
en-wikipedia-org-4107	749	1	"	"	``
en-wikipedia-org-4107	749	2	Effect	effect	NN
en-wikipedia-org-4107	749	3	of	of	IN
en-wikipedia-org-4107	749	4	treatment	treatment	NN
en-wikipedia-org-4107	749	5	modality	modality	NN
en-wikipedia-org-4107	749	6	on	on	IN
en-wikipedia-org-4107	749	7	long	long	JJ
en-wikipedia-org-4107	749	8	-	-	HYPH
en-wikipedia-org-4107	749	9	term	term	NN
en-wikipedia-org-4107	749	10	outcomes	outcome	NNS
en-wikipedia-org-4107	749	11	in	in	IN
en-wikipedia-org-4107	749	12	attention	attention	NN
en-wikipedia-org-4107	749	13	-	-	HYPH
en-wikipedia-org-4107	749	14	deficit	deficit	NN
en-wikipedia-org-4107	749	15	/	/	SYM
en-wikipedia-org-4107	749	16	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	749	17	disorder	disorder	NN
en-wikipedia-org-4107	749	18	:	:	:
en-wikipedia-org-4107	749	19	a	a	DT
en-wikipedia-org-4107	749	20	systematic	systematic	JJ
en-wikipedia-org-4107	749	21	review	review	NN
en-wikipedia-org-4107	749	22	"	"	''
en-wikipedia-org-4107	749	23	.	.	.
en-wikipedia-org-4107	750	1	PLOS	PLOS	NNP
en-wikipedia-org-4107	750	2	ONE	one	CD
en-wikipedia-org-4107	750	3	.	.	.
en-wikipedia-org-4107	751	1	10	10	CD
en-wikipedia-org-4107	751	2	(	(	-LRB-
en-wikipedia-org-4107	751	3	2	2	CD
en-wikipedia-org-4107	751	4	)	)	-RRB-
en-wikipedia-org-4107	751	5	:	:	:
en-wikipedia-org-4107	751	6	e0116407	e0116407	NN
en-wikipedia-org-4107	751	7	.	.	.
en-wikipedia-org-4107	752	1	doi:10.1371	doi:10.1371	NNP
en-wikipedia-org-4107	752	2	/	/	SYM
en-wikipedia-org-4107	752	3	journal.pone.0116407	journal.pone.0116407	NNP
en-wikipedia-org-4107	752	4	.	.	.
en-wikipedia-org-4107	753	1	PMC	PMC	NNP
en-wikipedia-org-4107	753	2	 	  	_SP
en-wikipedia-org-4107	753	3	4340791	4340791	CD
en-wikipedia-org-4107	753	4	.	.	.
en-wikipedia-org-4107	754	1	PMID	PMID	NNP
en-wikipedia-org-4107	754	2	 	  	_SP
en-wikipedia-org-4107	754	3	25714373	25714373	CD
en-wikipedia-org-4107	754	4	.	.	.
en-wikipedia-org-4107	755	1	The	the	DT
en-wikipedia-org-4107	755	2	highest	high	JJS
en-wikipedia-org-4107	755	3	proportion	proportion	NN
en-wikipedia-org-4107	755	4	of	of	IN
en-wikipedia-org-4107	755	5	improved	improved	JJ
en-wikipedia-org-4107	755	6	outcomes	outcome	NNS
en-wikipedia-org-4107	755	7	was	be	VBD
en-wikipedia-org-4107	755	8	reported	report	VBN
en-wikipedia-org-4107	755	9	with	with	IN
en-wikipedia-org-4107	755	10	combination	combination	NN
en-wikipedia-org-4107	755	11	treatment	treatment	NN
en-wikipedia-org-4107	755	12	(	(	-LRB-
en-wikipedia-org-4107	755	13	83	83	CD
en-wikipedia-org-4107	755	14	%	%	NN
en-wikipedia-org-4107	755	15	of	of	IN
en-wikipedia-org-4107	755	16	outcomes	outcome	NNS
en-wikipedia-org-4107	755	17	)	)	-RRB-
en-wikipedia-org-4107	755	18	.	.	.
en-wikipedia-org-4107	756	1	Among	among	IN
en-wikipedia-org-4107	756	2	significantly	significantly	RB
en-wikipedia-org-4107	756	3	improved	improve	VBN
en-wikipedia-org-4107	756	4	outcomes	outcome	NNS
en-wikipedia-org-4107	756	5	,	,	,
en-wikipedia-org-4107	756	6	the	the	DT
en-wikipedia-org-4107	756	7	largest	large	JJS
en-wikipedia-org-4107	756	8	effect	effect	NN
en-wikipedia-org-4107	756	9	sizes	size	NNS
en-wikipedia-org-4107	756	10	were	be	VBD
en-wikipedia-org-4107	756	11	found	find	VBN
en-wikipedia-org-4107	756	12	for	for	IN
en-wikipedia-org-4107	756	13	combination	combination	NN
en-wikipedia-org-4107	756	14	treatment	treatment	NN
en-wikipedia-org-4107	756	15	.	.	.
en-wikipedia-org-4107	757	1	The	the	DT
en-wikipedia-org-4107	757	2	greatest	great	JJS
en-wikipedia-org-4107	757	3	improvements	improvement	NNS
en-wikipedia-org-4107	757	4	were	be	VBD
en-wikipedia-org-4107	757	5	associated	associate	VBN
en-wikipedia-org-4107	757	6	with	with	IN
en-wikipedia-org-4107	757	7	academic	academic	JJ
en-wikipedia-org-4107	757	8	,	,	,
en-wikipedia-org-4107	757	9	self	self	NN
en-wikipedia-org-4107	757	10	-	-	HYPH
en-wikipedia-org-4107	757	11	esteem	esteem	NN
en-wikipedia-org-4107	757	12	,	,	,
en-wikipedia-org-4107	757	13	or	or	CC
en-wikipedia-org-4107	757	14	social	social	JJ
en-wikipedia-org-4107	757	15	function	function	NN
en-wikipedia-org-4107	757	16	outcomes	outcome	NNS
en-wikipedia-org-4107	757	17	.	.	.
en-wikipedia-org-4107	758	1	Figure	figure	NN
en-wikipedia-org-4107	758	2	3	3	CD
en-wikipedia-org-4107	758	3	:	:	:
en-wikipedia-org-4107	758	4	Treatment	treatment	NN
en-wikipedia-org-4107	758	5	benefit	benefit	NN
en-wikipedia-org-4107	758	6	by	by	IN
en-wikipedia-org-4107	758	7	treatment	treatment	NN
en-wikipedia-org-4107	758	8	type	type	NN
en-wikipedia-org-4107	758	9	and	and	CC
en-wikipedia-org-4107	758	10	outcome	outcome	NNP
en-wikipedia-org-4107	758	11	group	group	NN
en-wikipedia-org-4107	758	12	^	^	NNP
en-wikipedia-org-4107	758	13	a	a	DT
en-wikipedia-org-4107	758	14	b	b	NNP
en-wikipedia-org-4107	758	15	c	c	NNP
en-wikipedia-org-4107	758	16	Malenka	Malenka	NNP
en-wikipedia-org-4107	758	17	RC	RC	NNP
en-wikipedia-org-4107	758	18	,	,	,
en-wikipedia-org-4107	758	19	Nestler	Nestler	NNP
en-wikipedia-org-4107	758	20	EJ	EJ	NNP
en-wikipedia-org-4107	758	21	,	,	,
en-wikipedia-org-4107	758	22	Hyman	Hyman	NNP
en-wikipedia-org-4107	758	23	SE	SE	NNP
en-wikipedia-org-4107	758	24	(	(	-LRB-
en-wikipedia-org-4107	758	25	2009	2009	CD
en-wikipedia-org-4107	758	26	)	)	-RRB-
en-wikipedia-org-4107	758	27	.	.	.
en-wikipedia-org-4107	759	1	"	"	``
en-wikipedia-org-4107	759	2	Chapter	chapter	NN
en-wikipedia-org-4107	759	3	6	6	CD
en-wikipedia-org-4107	759	4	:	:	:
en-wikipedia-org-4107	759	5	Widely	widely	RB
en-wikipedia-org-4107	759	6	Projecting	project	VBG
en-wikipedia-org-4107	759	7	Systems	Systems	NNPS
en-wikipedia-org-4107	759	8	:	:	:
en-wikipedia-org-4107	759	9	Monoamines	monoamine	NNS
en-wikipedia-org-4107	759	10	,	,	,
en-wikipedia-org-4107	759	11	Acetylcholine	Acetylcholine	NNP
en-wikipedia-org-4107	759	12	,	,	,
en-wikipedia-org-4107	759	13	and	and	CC
en-wikipedia-org-4107	759	14	Orexin	Orexin	NNP
en-wikipedia-org-4107	759	15	"	"	''
en-wikipedia-org-4107	759	16	.	.	.
en-wikipedia-org-4107	760	1	In	in	IN
en-wikipedia-org-4107	760	2	Sydor	Sydor	NNP
en-wikipedia-org-4107	760	3	A	A	NNP
en-wikipedia-org-4107	760	4	,	,	,
en-wikipedia-org-4107	760	5	Brown	Brown	NNP
en-wikipedia-org-4107	760	6	RY	RY	NNP
en-wikipedia-org-4107	760	7	(	(	-LRB-
en-wikipedia-org-4107	760	8	eds	eds	NNP
en-wikipedia-org-4107	760	9	.	.	.
en-wikipedia-org-4107	760	10	)	)	-RRB-
en-wikipedia-org-4107	760	11	.	.	.
en-wikipedia-org-4107	761	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	761	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-4107	761	3	:	:	:
en-wikipedia-org-4107	761	4	A	A	NNP
en-wikipedia-org-4107	761	5	Foundation	Foundation	NNP
en-wikipedia-org-4107	761	6	for	for	IN
en-wikipedia-org-4107	761	7	Clinical	Clinical	NNP
en-wikipedia-org-4107	761	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	761	9	(	(	-LRB-
en-wikipedia-org-4107	761	10	2nd	2nd	NNP
en-wikipedia-org-4107	761	11	ed	ed	NNP
en-wikipedia-org-4107	761	12	.	.	.
en-wikipedia-org-4107	761	13	)	)	-RRB-
en-wikipedia-org-4107	761	14	.	.	.
en-wikipedia-org-4107	762	1	New	New	NNP
en-wikipedia-org-4107	762	2	York	York	NNP
en-wikipedia-org-4107	762	3	,	,	,
en-wikipedia-org-4107	762	4	USA	USA	NNP
en-wikipedia-org-4107	762	5	:	:	:
en-wikipedia-org-4107	762	6	McGraw	McGraw	NNP
en-wikipedia-org-4107	762	7	-	-	HYPH
en-wikipedia-org-4107	762	8	Hill	Hill	NNP
en-wikipedia-org-4107	762	9	Medical	Medical	NNP
en-wikipedia-org-4107	762	10	.	.	.
en-wikipedia-org-4107	763	1	pp	pp	NNP
en-wikipedia-org-4107	763	2	.	.	.
en-wikipedia-org-4107	764	1	154–157	154–157	CD
en-wikipedia-org-4107	764	2	.	.	.
en-wikipedia-org-4107	765	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	765	2	 	  	_SP
en-wikipedia-org-4107	765	3	9780071481274	9780071481274	CD
en-wikipedia-org-4107	765	4	.	.	.
en-wikipedia-org-4107	766	1	^	^	NNP
en-wikipedia-org-4107	766	2	a	a	DT
en-wikipedia-org-4107	766	3	b	b	NNP
en-wikipedia-org-4107	766	4	c	c	NN
en-wikipedia-org-4107	766	5	d	d	NN
en-wikipedia-org-4107	766	6	e	e	NNP
en-wikipedia-org-4107	766	7	Bidwell	Bidwell	NNP
en-wikipedia-org-4107	766	8	LC	LC	NNP
en-wikipedia-org-4107	766	9	,	,	,
en-wikipedia-org-4107	766	10	McClernon	McClernon	NNP
en-wikipedia-org-4107	766	11	FJ	FJ	NNP
en-wikipedia-org-4107	766	12	,	,	,
en-wikipedia-org-4107	766	13	Kollins	Kollins	NNP
en-wikipedia-org-4107	766	14	SH	SH	NNP
en-wikipedia-org-4107	766	15	(	(	-LRB-
en-wikipedia-org-4107	766	16	August	August	NNP
en-wikipedia-org-4107	766	17	2011	2011	CD
en-wikipedia-org-4107	766	18	)	)	-RRB-
en-wikipedia-org-4107	766	19	.	.	.
en-wikipedia-org-4107	767	1	"	"	``
en-wikipedia-org-4107	767	2	Cognitive	cognitive	JJ
en-wikipedia-org-4107	767	3	enhancers	enhancer	NNS
en-wikipedia-org-4107	767	4	for	for	IN
en-wikipedia-org-4107	767	5	the	the	DT
en-wikipedia-org-4107	767	6	treatment	treatment	NN
en-wikipedia-org-4107	767	7	of	of	IN
en-wikipedia-org-4107	767	8	ADHD	ADHD	NNP
en-wikipedia-org-4107	767	9	"	"	''
en-wikipedia-org-4107	767	10	.	.	.
en-wikipedia-org-4107	768	1	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	768	2	Biochemistry	Biochemistry	NNP
en-wikipedia-org-4107	768	3	and	and	CC
en-wikipedia-org-4107	768	4	Behavior	Behavior	NNP
en-wikipedia-org-4107	768	5	.	.	.
en-wikipedia-org-4107	769	1	99	99	CD
en-wikipedia-org-4107	769	2	(	(	-LRB-
en-wikipedia-org-4107	769	3	2	2	CD
en-wikipedia-org-4107	769	4	)	)	-RRB-
en-wikipedia-org-4107	769	5	:	:	:
en-wikipedia-org-4107	769	6	262–274	262–274	CD
en-wikipedia-org-4107	769	7	.	.	.
en-wikipedia-org-4107	770	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	770	2	/	/	SYM
en-wikipedia-org-4107	770	3	j.pbb.2011.05.002	j.pbb.2011.05.002	NNP
en-wikipedia-org-4107	770	4	.	.	.
en-wikipedia-org-4107	771	1	PMC	PMC	NNP
en-wikipedia-org-4107	771	2	 	  	_SP
en-wikipedia-org-4107	771	3	3353150	3353150	CD
en-wikipedia-org-4107	771	4	.	.	.
en-wikipedia-org-4107	772	1	PMID	PMID	NNP
en-wikipedia-org-4107	772	2	 	  	_SP
en-wikipedia-org-4107	772	3	21596055	21596055	CD
en-wikipedia-org-4107	772	4	.	.	.
en-wikipedia-org-4107	773	1	^	^	NN
en-wikipedia-org-4107	773	2	Parker	Parker	NNP
en-wikipedia-org-4107	773	3	J	J	NNP
en-wikipedia-org-4107	773	4	,	,	,
en-wikipedia-org-4107	773	5	Wales	Wales	NNP
en-wikipedia-org-4107	773	6	G	G	NNP
en-wikipedia-org-4107	773	7	,	,	,
en-wikipedia-org-4107	773	8	Chalhoub	Chalhoub	NNP
en-wikipedia-org-4107	773	9	N	N	NNP
en-wikipedia-org-4107	773	10	,	,	,
en-wikipedia-org-4107	773	11	Harpin	Harpin	NNP
en-wikipedia-org-4107	773	12	V	V	NNP
en-wikipedia-org-4107	773	13	(	(	-LRB-
en-wikipedia-org-4107	773	14	September	September	NNP
en-wikipedia-org-4107	773	15	2013	2013	CD
en-wikipedia-org-4107	773	16	)	)	-RRB-
en-wikipedia-org-4107	773	17	.	.	.
en-wikipedia-org-4107	774	1	"	"	``
en-wikipedia-org-4107	774	2	The	the	DT
en-wikipedia-org-4107	774	3	long	long	JJ
en-wikipedia-org-4107	774	4	-	-	HYPH
en-wikipedia-org-4107	774	5	term	term	NN
en-wikipedia-org-4107	774	6	outcomes	outcome	NNS
en-wikipedia-org-4107	774	7	of	of	IN
en-wikipedia-org-4107	774	8	interventions	intervention	NNS
en-wikipedia-org-4107	774	9	for	for	IN
en-wikipedia-org-4107	774	10	the	the	DT
en-wikipedia-org-4107	774	11	management	management	NN
en-wikipedia-org-4107	774	12	of	of	IN
en-wikipedia-org-4107	774	13	attention	attention	NN
en-wikipedia-org-4107	774	14	-	-	HYPH
en-wikipedia-org-4107	774	15	deficit	deficit	NN
en-wikipedia-org-4107	774	16	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	774	17	disorder	disorder	NN
en-wikipedia-org-4107	774	18	in	in	IN
en-wikipedia-org-4107	774	19	children	child	NNS
en-wikipedia-org-4107	774	20	and	and	CC
en-wikipedia-org-4107	774	21	adolescents	adolescent	NNS
en-wikipedia-org-4107	774	22	:	:	:
en-wikipedia-org-4107	774	23	a	a	DT
en-wikipedia-org-4107	774	24	systematic	systematic	JJ
en-wikipedia-org-4107	774	25	review	review	NN
en-wikipedia-org-4107	774	26	of	of	IN
en-wikipedia-org-4107	774	27	randomized	randomized	JJ
en-wikipedia-org-4107	774	28	controlled	controlled	JJ
en-wikipedia-org-4107	774	29	trials	trial	NNS
en-wikipedia-org-4107	774	30	"	"	''
en-wikipedia-org-4107	774	31	.	.	.
en-wikipedia-org-4107	775	1	Psychology	Psychology	NNP
en-wikipedia-org-4107	775	2	Research	Research	NNP
en-wikipedia-org-4107	775	3	and	and	CC
en-wikipedia-org-4107	775	4	Behavior	Behavior	NNP
en-wikipedia-org-4107	775	5	Management	Management	NNP
en-wikipedia-org-4107	775	6	.	.	.
en-wikipedia-org-4107	776	1	6	6	CD
en-wikipedia-org-4107	776	2	:	:	:
en-wikipedia-org-4107	776	3	87–99	87–99	CD
en-wikipedia-org-4107	776	4	.	.	.
en-wikipedia-org-4107	777	1	doi:10.2147	doi:10.2147	NNP
en-wikipedia-org-4107	777	2	/	/	SYM
en-wikipedia-org-4107	777	3	PRBM.S49114	PRBM.S49114	NNP
en-wikipedia-org-4107	777	4	.	.	.
en-wikipedia-org-4107	778	1	PMC	PMC	NNP
en-wikipedia-org-4107	778	2	 	  	_SP
en-wikipedia-org-4107	778	3	3785407	3785407	CD
en-wikipedia-org-4107	778	4	.	.	.
en-wikipedia-org-4107	779	1	PMID	PMID	NNP
en-wikipedia-org-4107	779	2	 	  	_SP
en-wikipedia-org-4107	779	3	24082796	24082796	CD
en-wikipedia-org-4107	779	4	.	.	.
en-wikipedia-org-4107	780	1	Only	only	RB
en-wikipedia-org-4107	780	2	one	one	CD
en-wikipedia-org-4107	780	3	paper53	paper53	NN
en-wikipedia-org-4107	780	4	examining	examine	VBG
en-wikipedia-org-4107	780	5	outcomes	outcome	NNS
en-wikipedia-org-4107	780	6	beyond	beyond	IN
en-wikipedia-org-4107	780	7	36	36	CD
en-wikipedia-org-4107	780	8	months	month	NNS
en-wikipedia-org-4107	780	9	met	meet	VBD
en-wikipedia-org-4107	780	10	the	the	DT
en-wikipedia-org-4107	780	11	review	review	NN
en-wikipedia-org-4107	780	12	criteria	criterion	NNS
en-wikipedia-org-4107	780	13	.	.	.
en-wikipedia-org-4107	781	1	...	...	NFP
en-wikipedia-org-4107	782	1	There	there	EX
en-wikipedia-org-4107	782	2	is	be	VBZ
en-wikipedia-org-4107	782	3	high	high	JJ
en-wikipedia-org-4107	782	4	level	level	NN
en-wikipedia-org-4107	782	5	evidence	evidence	NN
en-wikipedia-org-4107	782	6	suggesting	suggest	VBG
en-wikipedia-org-4107	782	7	that	that	IN
en-wikipedia-org-4107	782	8	pharmacological	pharmacological	JJ
en-wikipedia-org-4107	782	9	treatment	treatment	NN
en-wikipedia-org-4107	782	10	can	can	MD
en-wikipedia-org-4107	782	11	have	have	VB
en-wikipedia-org-4107	782	12	a	a	DT
en-wikipedia-org-4107	782	13	major	major	JJ
en-wikipedia-org-4107	782	14	beneficial	beneficial	JJ
en-wikipedia-org-4107	782	15	effect	effect	NN
en-wikipedia-org-4107	782	16	on	on	IN
en-wikipedia-org-4107	782	17	the	the	DT
en-wikipedia-org-4107	782	18	core	core	NN
en-wikipedia-org-4107	782	19	symptoms	symptom	NNS
en-wikipedia-org-4107	782	20	of	of	IN
en-wikipedia-org-4107	782	21	ADHD	ADHD	NNP
en-wikipedia-org-4107	782	22	(	(	-LRB-
en-wikipedia-org-4107	782	23	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	782	24	,	,	,
en-wikipedia-org-4107	782	25	inattention	inattention	NN
en-wikipedia-org-4107	782	26	,	,	,
en-wikipedia-org-4107	782	27	and	and	CC
en-wikipedia-org-4107	782	28	impulsivity	impulsivity	NN
en-wikipedia-org-4107	782	29	)	)	-RRB-
en-wikipedia-org-4107	782	30	in	in	IN
en-wikipedia-org-4107	782	31	approximately	approximately	RB
en-wikipedia-org-4107	782	32	80	80	CD
en-wikipedia-org-4107	782	33	%	%	NN
en-wikipedia-org-4107	782	34	of	of	IN
en-wikipedia-org-4107	782	35	cases	case	NNS
en-wikipedia-org-4107	782	36	compared	compare	VBN
en-wikipedia-org-4107	782	37	with	with	IN
en-wikipedia-org-4107	782	38	placebo	placebo	NN
en-wikipedia-org-4107	782	39	controls	control	NNS
en-wikipedia-org-4107	782	40	,	,	,
en-wikipedia-org-4107	782	41	in	in	IN
en-wikipedia-org-4107	782	42	the	the	DT
en-wikipedia-org-4107	782	43	short	short	JJ
en-wikipedia-org-4107	782	44	term	term	NN
en-wikipedia-org-4107	782	45	.	.	.
en-wikipedia-org-4107	783	1	^	^	NFP
en-wikipedia-org-4107	783	2	Millichap	Millichap	NNP
en-wikipedia-org-4107	783	3	JG	JG	NNP
en-wikipedia-org-4107	783	4	(	(	-LRB-
en-wikipedia-org-4107	783	5	2010	2010	CD
en-wikipedia-org-4107	783	6	)	)	-RRB-
en-wikipedia-org-4107	783	7	.	.	.
en-wikipedia-org-4107	784	1	"	"	``
en-wikipedia-org-4107	784	2	Chapter	chapter	NN
en-wikipedia-org-4107	784	3	9	9	CD
en-wikipedia-org-4107	784	4	:	:	:
en-wikipedia-org-4107	784	5	Medications	medication	NNS
en-wikipedia-org-4107	784	6	for	for	IN
en-wikipedia-org-4107	784	7	ADHD	ADHD	NNP
en-wikipedia-org-4107	784	8	"	"	''
en-wikipedia-org-4107	784	9	.	.	.
en-wikipedia-org-4107	785	1	In	in	IN
en-wikipedia-org-4107	785	2	Millichap	Millichap	NNP
en-wikipedia-org-4107	785	3	JG	JG	NNP
en-wikipedia-org-4107	785	4	(	(	-LRB-
en-wikipedia-org-4107	785	5	ed	ed	NNP
en-wikipedia-org-4107	785	6	.	.	.
en-wikipedia-org-4107	785	7	)	)	-RRB-
en-wikipedia-org-4107	785	8	.	.	.
en-wikipedia-org-4107	786	1	Attention	attention	NN
en-wikipedia-org-4107	786	2	Deficit	Deficit	NNP
en-wikipedia-org-4107	786	3	Hyperactivity	Hyperactivity	NNP
en-wikipedia-org-4107	786	4	Disorder	Disorder	NNP
en-wikipedia-org-4107	786	5	Handbook	Handbook	NNP
en-wikipedia-org-4107	786	6	:	:	:
en-wikipedia-org-4107	786	7	A	a	DT
en-wikipedia-org-4107	786	8	Physician	Physician	NNP
en-wikipedia-org-4107	786	9	's	's	POS
en-wikipedia-org-4107	786	10	Guide	Guide	NNP
en-wikipedia-org-4107	786	11	to	to	IN
en-wikipedia-org-4107	786	12	ADHD	ADHD	NNP
en-wikipedia-org-4107	786	13	(	(	-LRB-
en-wikipedia-org-4107	786	14	2nd	2nd	NNP
en-wikipedia-org-4107	786	15	ed	ed	NNP
en-wikipedia-org-4107	786	16	.	.	.
en-wikipedia-org-4107	786	17	)	)	-RRB-
en-wikipedia-org-4107	786	18	.	.	.
en-wikipedia-org-4107	787	1	New	New	NNP
en-wikipedia-org-4107	787	2	York	York	NNP
en-wikipedia-org-4107	787	3	,	,	,
en-wikipedia-org-4107	787	4	USA	USA	NNP
en-wikipedia-org-4107	787	5	:	:	:
en-wikipedia-org-4107	787	6	Springer	Springer	NNP
en-wikipedia-org-4107	787	7	.	.	.
en-wikipedia-org-4107	788	1	pp	pp	NNP
en-wikipedia-org-4107	788	2	.	.	.
en-wikipedia-org-4107	789	1	111–113	111–113	CD
en-wikipedia-org-4107	789	2	.	.	.
en-wikipedia-org-4107	790	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	790	2	 	  	_SP
en-wikipedia-org-4107	790	3	9781441913968	9781441913968	CD
en-wikipedia-org-4107	790	4	.	.	.
en-wikipedia-org-4107	791	1	^	^	FW
en-wikipedia-org-4107	791	2	"	"	``
en-wikipedia-org-4107	791	3	Stimulants	stimulant	NNS
en-wikipedia-org-4107	791	4	for	for	IN
en-wikipedia-org-4107	791	5	Attention	Attention	NNP
en-wikipedia-org-4107	791	6	Deficit	Deficit	NNP
en-wikipedia-org-4107	791	7	Hyperactivity	Hyperactivity	NNP
en-wikipedia-org-4107	791	8	Disorder	Disorder	NNP
en-wikipedia-org-4107	791	9	"	"	''
en-wikipedia-org-4107	791	10	.	.	.
en-wikipedia-org-4107	792	1	WebMD	WebMD	NNP
en-wikipedia-org-4107	792	2	.	.	.
en-wikipedia-org-4107	793	1	Healthwise	Healthwise	NNP
en-wikipedia-org-4107	793	2	.	.	.
en-wikipedia-org-4107	794	1	12	12	CD
en-wikipedia-org-4107	794	2	April	April	NNP
en-wikipedia-org-4107	794	3	2010	2010	CD
en-wikipedia-org-4107	794	4	.	.	.
en-wikipedia-org-4107	795	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	795	2	12	12	CD
en-wikipedia-org-4107	795	3	November	November	NNP
en-wikipedia-org-4107	795	4	2013	2013	CD
en-wikipedia-org-4107	795	5	.	.	.
en-wikipedia-org-4107	796	1	^	^	NNP
en-wikipedia-org-4107	796	2	Scholten	Scholten	NNP
en-wikipedia-org-4107	796	3	RJ	RJ	NNP
en-wikipedia-org-4107	796	4	,	,	,
en-wikipedia-org-4107	796	5	Clarke	Clarke	NNP
en-wikipedia-org-4107	796	6	M	M	NNP
en-wikipedia-org-4107	796	7	,	,	,
en-wikipedia-org-4107	796	8	Hetherington	Hetherington	NNP
en-wikipedia-org-4107	796	9	J	J	NNP
en-wikipedia-org-4107	796	10	(	(	-LRB-
en-wikipedia-org-4107	796	11	August	August	NNP
en-wikipedia-org-4107	796	12	2005	2005	CD
en-wikipedia-org-4107	796	13	)	)	-RRB-
en-wikipedia-org-4107	796	14	.	.	.
en-wikipedia-org-4107	797	1	"	"	``
en-wikipedia-org-4107	797	2	The	the	DT
en-wikipedia-org-4107	797	3	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	797	4	Collaboration	Collaboration	NNP
en-wikipedia-org-4107	797	5	"	"	''
en-wikipedia-org-4107	797	6	.	.	.
en-wikipedia-org-4107	798	1	European	European	NNP
en-wikipedia-org-4107	798	2	Journal	Journal	NNP
en-wikipedia-org-4107	798	3	of	of	IN
en-wikipedia-org-4107	798	4	Clinical	Clinical	NNP
en-wikipedia-org-4107	798	5	Nutrition	Nutrition	NNP
en-wikipedia-org-4107	798	6	.	.	.
en-wikipedia-org-4107	799	1	59	59	LS
en-wikipedia-org-4107	799	2	(	(	-LRB-
en-wikipedia-org-4107	799	3	Suppl	Suppl	NNP
en-wikipedia-org-4107	799	4	1	1	CD
en-wikipedia-org-4107	799	5	)	)	-RRB-
en-wikipedia-org-4107	799	6	:	:	:
en-wikipedia-org-4107	799	7	S147–S149	s147–s149	NN
en-wikipedia-org-4107	799	8	,	,	,
en-wikipedia-org-4107	799	9	discussion	discussion	NN
en-wikipedia-org-4107	799	10	S195–S196	s195–s196	NN
en-wikipedia-org-4107	799	11	.	.	.
en-wikipedia-org-4107	800	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-4107	800	2	/	/	SYM
en-wikipedia-org-4107	800	3	sj.ejcn.1602188	sj.ejcn.1602188	NNP
en-wikipedia-org-4107	800	4	.	.	.
en-wikipedia-org-4107	801	1	PMID	PMID	NNP
en-wikipedia-org-4107	801	2	 	  	_SP
en-wikipedia-org-4107	801	3	16052183	16052183	CD
en-wikipedia-org-4107	801	4	.	.	.
en-wikipedia-org-4107	802	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	802	2	 	  	_SP
en-wikipedia-org-4107	802	3	29410060	29410060	CD
en-wikipedia-org-4107	802	4	.	.	.
en-wikipedia-org-4107	803	1	^	^	NNP
en-wikipedia-org-4107	803	2	a	a	DT
en-wikipedia-org-4107	803	3	b	b	NNP
en-wikipedia-org-4107	803	4	Castells	Castells	NNP
en-wikipedia-org-4107	803	5	X	X	NNP
en-wikipedia-org-4107	803	6	,	,	,
en-wikipedia-org-4107	803	7	Blanco	Blanco	NNP
en-wikipedia-org-4107	803	8	-	-	HYPH
en-wikipedia-org-4107	803	9	Silvente	Silvente	NNP
en-wikipedia-org-4107	803	10	L	L	NNP
en-wikipedia-org-4107	803	11	,	,	,
en-wikipedia-org-4107	803	12	Cunill	Cunill	NNP
en-wikipedia-org-4107	803	13	R	R	NNP
en-wikipedia-org-4107	803	14	(	(	-LRB-
en-wikipedia-org-4107	803	15	August	August	NNP
en-wikipedia-org-4107	803	16	2018	2018	CD
en-wikipedia-org-4107	803	17	)	)	-RRB-
en-wikipedia-org-4107	803	18	.	.	.
en-wikipedia-org-4107	804	1	"	"	``
en-wikipedia-org-4107	804	2	Amphetamines	amphetamine	NNS
en-wikipedia-org-4107	804	3	for	for	IN
en-wikipedia-org-4107	804	4	attention	attention	NN
en-wikipedia-org-4107	804	5	deficit	deficit	NN
en-wikipedia-org-4107	804	6	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	804	7	disorder	disorder	NN
en-wikipedia-org-4107	804	8	(	(	-LRB-
en-wikipedia-org-4107	804	9	ADHD	ADHD	NNP
en-wikipedia-org-4107	804	10	)	)	-RRB-
en-wikipedia-org-4107	804	11	in	in	IN
en-wikipedia-org-4107	804	12	adults	adult	NNS
en-wikipedia-org-4107	804	13	"	"	''
en-wikipedia-org-4107	804	14	.	.	.
en-wikipedia-org-4107	805	1	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	805	2	Database	Database	NNP
en-wikipedia-org-4107	805	3	of	of	IN
en-wikipedia-org-4107	805	4	Systematic	Systematic	NNP
en-wikipedia-org-4107	805	5	Reviews	Reviews	NNPS
en-wikipedia-org-4107	805	6	.	.	.
en-wikipedia-org-4107	806	1	8	8	CD
en-wikipedia-org-4107	806	2	:	:	SYM
en-wikipedia-org-4107	806	3	CD007813	CD007813	NNP
en-wikipedia-org-4107	806	4	.	.	.
en-wikipedia-org-4107	807	1	doi:10.1002/14651858.CD007813.pub3	doi:10.1002/14651858.CD007813.pub3	NNS
en-wikipedia-org-4107	807	2	.	.	.
en-wikipedia-org-4107	808	1	PMC	PMC	NNP
en-wikipedia-org-4107	808	2	 	  	_SP
en-wikipedia-org-4107	808	3	6513464	6513464	CD
en-wikipedia-org-4107	808	4	.	.	.
en-wikipedia-org-4107	809	1	PMID	PMID	NNP
en-wikipedia-org-4107	809	2	 	  	_SP
en-wikipedia-org-4107	809	3	30091808	30091808	CD
en-wikipedia-org-4107	809	4	.	.	.
en-wikipedia-org-4107	810	1	^	^	NFP
en-wikipedia-org-4107	810	2	Punja	Punja	NNP
en-wikipedia-org-4107	810	3	S	S	NNP
en-wikipedia-org-4107	810	4	,	,	,
en-wikipedia-org-4107	810	5	Shamseer	Shamseer	NNP
en-wikipedia-org-4107	810	6	L	L	NNP
en-wikipedia-org-4107	810	7	,	,	,
en-wikipedia-org-4107	810	8	Hartling	Hartling	NNP
en-wikipedia-org-4107	810	9	L	L	NNP
en-wikipedia-org-4107	810	10	,	,	,
en-wikipedia-org-4107	810	11	Urichuk	Urichuk	NNP
en-wikipedia-org-4107	810	12	L	L	NNP
en-wikipedia-org-4107	810	13	,	,	,
en-wikipedia-org-4107	810	14	Vandermeer	Vandermeer	NNP
en-wikipedia-org-4107	810	15	B	B	NNP
en-wikipedia-org-4107	810	16	,	,	,
en-wikipedia-org-4107	810	17	Nikles	Nikles	NNP
en-wikipedia-org-4107	810	18	J	J	NNP
en-wikipedia-org-4107	810	19	,	,	,
en-wikipedia-org-4107	810	20	Vohra	Vohra	NNP
en-wikipedia-org-4107	810	21	S	S	NNP
en-wikipedia-org-4107	810	22	(	(	-LRB-
en-wikipedia-org-4107	810	23	February	February	NNP
en-wikipedia-org-4107	810	24	2016	2016	CD
en-wikipedia-org-4107	810	25	)	)	-RRB-
en-wikipedia-org-4107	810	26	.	.	.
en-wikipedia-org-4107	811	1	"	"	``
en-wikipedia-org-4107	811	2	Amphetamines	amphetamine	NNS
en-wikipedia-org-4107	811	3	for	for	IN
en-wikipedia-org-4107	811	4	attention	attention	NN
en-wikipedia-org-4107	811	5	deficit	deficit	NN
en-wikipedia-org-4107	811	6	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	811	7	disorder	disorder	NN
en-wikipedia-org-4107	811	8	(	(	-LRB-
en-wikipedia-org-4107	811	9	ADHD	ADHD	NNP
en-wikipedia-org-4107	811	10	)	)	-RRB-
en-wikipedia-org-4107	811	11	in	in	IN
en-wikipedia-org-4107	811	12	children	child	NNS
en-wikipedia-org-4107	811	13	and	and	CC
en-wikipedia-org-4107	811	14	adolescents	adolescent	NNS
en-wikipedia-org-4107	811	15	"	"	''
en-wikipedia-org-4107	811	16	.	.	.
en-wikipedia-org-4107	812	1	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	812	2	Database	Database	NNP
en-wikipedia-org-4107	812	3	of	of	IN
en-wikipedia-org-4107	812	4	Systematic	Systematic	NNP
en-wikipedia-org-4107	812	5	Reviews	Reviews	NNPS
en-wikipedia-org-4107	812	6	.	.	.
en-wikipedia-org-4107	813	1	2	2	LS
en-wikipedia-org-4107	813	2	:	:	:
en-wikipedia-org-4107	813	3	CD009996	CD009996	NNP
en-wikipedia-org-4107	813	4	.	.	.
en-wikipedia-org-4107	814	1	doi:10.1002/14651858.CD009996.pub2	doi:10.1002/14651858.cd009996.pub2	UH
en-wikipedia-org-4107	814	2	.	.	.
en-wikipedia-org-4107	815	1	PMID	PMID	NNP
en-wikipedia-org-4107	815	2	 	  	_SP
en-wikipedia-org-4107	815	3	26844979	26844979	CD
en-wikipedia-org-4107	815	4	.	.	.
en-wikipedia-org-4107	816	1	^	^	NNP
en-wikipedia-org-4107	816	2	Osland	Osland	NNP
en-wikipedia-org-4107	816	3	ST	ST	NNP
en-wikipedia-org-4107	816	4	,	,	,
en-wikipedia-org-4107	816	5	Steeves	Steeves	NNP
en-wikipedia-org-4107	816	6	TD	TD	NNP
en-wikipedia-org-4107	816	7	,	,	,
en-wikipedia-org-4107	816	8	Pringsheim	Pringsheim	NNP
en-wikipedia-org-4107	816	9	T	T	NNP
en-wikipedia-org-4107	816	10	(	(	-LRB-
en-wikipedia-org-4107	816	11	June	June	NNP
en-wikipedia-org-4107	816	12	2018	2018	CD
en-wikipedia-org-4107	816	13	)	)	-RRB-
en-wikipedia-org-4107	816	14	.	.	.
en-wikipedia-org-4107	817	1	"	"	``
en-wikipedia-org-4107	817	2	Pharmacological	pharmacological	JJ
en-wikipedia-org-4107	817	3	treatment	treatment	NN
en-wikipedia-org-4107	817	4	for	for	IN
en-wikipedia-org-4107	817	5	attention	attention	NN
en-wikipedia-org-4107	817	6	deficit	deficit	NN
en-wikipedia-org-4107	817	7	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	817	8	disorder	disorder	NN
en-wikipedia-org-4107	817	9	(	(	-LRB-
en-wikipedia-org-4107	817	10	ADHD	ADHD	NNP
en-wikipedia-org-4107	817	11	)	)	-RRB-
en-wikipedia-org-4107	817	12	in	in	IN
en-wikipedia-org-4107	817	13	children	child	NNS
en-wikipedia-org-4107	817	14	with	with	IN
en-wikipedia-org-4107	817	15	comorbid	comorbid	NN
en-wikipedia-org-4107	817	16	tic	tic	JJ
en-wikipedia-org-4107	817	17	disorders	disorder	NNS
en-wikipedia-org-4107	817	18	"	"	''
en-wikipedia-org-4107	817	19	.	.	.
en-wikipedia-org-4107	818	1	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	818	2	Database	Database	NNP
en-wikipedia-org-4107	818	3	of	of	IN
en-wikipedia-org-4107	818	4	Systematic	Systematic	NNP
en-wikipedia-org-4107	818	5	Reviews	Reviews	NNPS
en-wikipedia-org-4107	818	6	.	.	.
en-wikipedia-org-4107	819	1	6	6	CD
en-wikipedia-org-4107	819	2	:	:	:
en-wikipedia-org-4107	819	3	CD007990	CD007990	NNP
en-wikipedia-org-4107	819	4	.	.	.
en-wikipedia-org-4107	820	1	doi:10.1002/14651858.CD007990.pub3	doi:10.1002/14651858.CD007990.pub3	NNP
en-wikipedia-org-4107	820	2	.	.	.
en-wikipedia-org-4107	821	1	PMC	PMC	NNP
en-wikipedia-org-4107	821	2	 	  	_SP
en-wikipedia-org-4107	821	3	6513283	6513283	CD
en-wikipedia-org-4107	821	4	.	.	.
en-wikipedia-org-4107	822	1	PMID	PMID	NNP
en-wikipedia-org-4107	822	2	 	  	_SP
en-wikipedia-org-4107	822	3	29944175	29944175	CD
en-wikipedia-org-4107	822	4	.	.	.
en-wikipedia-org-4107	823	1	^	^	NNP
en-wikipedia-org-4107	823	2	a	a	DT
en-wikipedia-org-4107	823	3	b	b	NN
en-wikipedia-org-4107	823	4	Spencer	Spencer	NNP
en-wikipedia-org-4107	823	5	RC	RC	NNP
en-wikipedia-org-4107	823	6	,	,	,
en-wikipedia-org-4107	823	7	Devilbiss	Devilbiss	NNP
en-wikipedia-org-4107	823	8	DM	DM	NNP
en-wikipedia-org-4107	823	9	,	,	,
en-wikipedia-org-4107	823	10	Berridge	Berridge	NNP
en-wikipedia-org-4107	823	11	CW	CW	NNP
en-wikipedia-org-4107	823	12	(	(	-LRB-
en-wikipedia-org-4107	823	13	June	June	NNP
en-wikipedia-org-4107	823	14	2015	2015	CD
en-wikipedia-org-4107	823	15	)	)	-RRB-
en-wikipedia-org-4107	823	16	.	.	.
en-wikipedia-org-4107	824	1	"	"	``
en-wikipedia-org-4107	824	2	The	the	DT
en-wikipedia-org-4107	824	3	Cognition	Cognition	NNP
en-wikipedia-org-4107	824	4	-	-	HYPH
en-wikipedia-org-4107	824	5	Enhancing	Enhancing	NNP
en-wikipedia-org-4107	824	6	Effects	Effects	NNPS
en-wikipedia-org-4107	824	7	of	of	IN
en-wikipedia-org-4107	824	8	Psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	824	9	Involve	involve	VBP
en-wikipedia-org-4107	824	10	Direct	direct	JJ
en-wikipedia-org-4107	824	11	Action	Action	NNP
en-wikipedia-org-4107	824	12	in	in	IN
en-wikipedia-org-4107	824	13	the	the	DT
en-wikipedia-org-4107	824	14	Prefrontal	Prefrontal	NNP
en-wikipedia-org-4107	824	15	Cortex	Cortex	NNP
en-wikipedia-org-4107	824	16	"	"	''
en-wikipedia-org-4107	824	17	.	.	.
en-wikipedia-org-4107	825	1	Biological	biological	JJ
en-wikipedia-org-4107	825	2	Psychiatry	Psychiatry	NNP
en-wikipedia-org-4107	825	3	.	.	.
en-wikipedia-org-4107	826	1	77	77	CD
en-wikipedia-org-4107	826	2	(	(	-LRB-
en-wikipedia-org-4107	826	3	11	11	CD
en-wikipedia-org-4107	826	4	)	)	-RRB-
en-wikipedia-org-4107	826	5	:	:	:
en-wikipedia-org-4107	826	6	940–950	940–950	CD
en-wikipedia-org-4107	826	7	.	.	.
en-wikipedia-org-4107	827	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	827	2	/	/	SYM
en-wikipedia-org-4107	827	3	j.biopsych.2014.09.013	j.biopsych.2014.09.013	JJ
en-wikipedia-org-4107	827	4	.	.	.
en-wikipedia-org-4107	828	1	PMC	PMC	NNP
en-wikipedia-org-4107	828	2	 	  	_SP
en-wikipedia-org-4107	828	3	4377121	4377121	CD
en-wikipedia-org-4107	828	4	.	.	.
en-wikipedia-org-4107	829	1	PMID	PMID	NNP
en-wikipedia-org-4107	829	2	 	  	_SP
en-wikipedia-org-4107	829	3	25499957	25499957	CD
en-wikipedia-org-4107	829	4	.	.	.
en-wikipedia-org-4107	830	1	The	the	DT
en-wikipedia-org-4107	830	2	procognitive	procognitive	JJ
en-wikipedia-org-4107	830	3	actions	action	NNS
en-wikipedia-org-4107	830	4	of	of	IN
en-wikipedia-org-4107	830	5	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	830	6	are	be	VBP
en-wikipedia-org-4107	830	7	only	only	RB
en-wikipedia-org-4107	830	8	associated	associate	VBN
en-wikipedia-org-4107	830	9	with	with	IN
en-wikipedia-org-4107	830	10	low	low	JJ
en-wikipedia-org-4107	830	11	doses	dose	NNS
en-wikipedia-org-4107	830	12	.	.	.
en-wikipedia-org-4107	831	1	Surprisingly	surprisingly	RB
en-wikipedia-org-4107	831	2	,	,	,
en-wikipedia-org-4107	831	3	despite	despite	IN
en-wikipedia-org-4107	831	4	nearly	nearly	RB
en-wikipedia-org-4107	831	5	80	80	CD
en-wikipedia-org-4107	831	6	years	year	NNS
en-wikipedia-org-4107	831	7	of	of	IN
en-wikipedia-org-4107	831	8	clinical	clinical	JJ
en-wikipedia-org-4107	831	9	use	use	NN
en-wikipedia-org-4107	831	10	,	,	,
en-wikipedia-org-4107	831	11	the	the	DT
en-wikipedia-org-4107	831	12	neurobiology	neurobiology	NN
en-wikipedia-org-4107	831	13	of	of	IN
en-wikipedia-org-4107	831	14	the	the	DT
en-wikipedia-org-4107	831	15	procognitive	procognitive	JJ
en-wikipedia-org-4107	831	16	actions	action	NNS
en-wikipedia-org-4107	831	17	of	of	IN
en-wikipedia-org-4107	831	18	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	831	19	has	have	VBZ
en-wikipedia-org-4107	831	20	only	only	RB
en-wikipedia-org-4107	831	21	recently	recently	RB
en-wikipedia-org-4107	831	22	been	be	VBN
en-wikipedia-org-4107	831	23	systematically	systematically	RB
en-wikipedia-org-4107	831	24	investigated	investigate	VBN
en-wikipedia-org-4107	831	25	.	.	.
en-wikipedia-org-4107	832	1	Findings	finding	NNS
en-wikipedia-org-4107	832	2	from	from	IN
en-wikipedia-org-4107	832	3	this	this	DT
en-wikipedia-org-4107	832	4	research	research	NN
en-wikipedia-org-4107	832	5	unambiguously	unambiguously	RB
en-wikipedia-org-4107	832	6	demonstrate	demonstrate	VBP
en-wikipedia-org-4107	832	7	that	that	IN
en-wikipedia-org-4107	832	8	the	the	DT
en-wikipedia-org-4107	832	9	cognition	cognition	NN
en-wikipedia-org-4107	832	10	-	-	HYPH
en-wikipedia-org-4107	832	11	enhancing	enhance	VBG
en-wikipedia-org-4107	832	12	effects	effect	NNS
en-wikipedia-org-4107	832	13	of	of	IN
en-wikipedia-org-4107	832	14	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	832	15	involve	involve	VBP
en-wikipedia-org-4107	832	16	the	the	DT
en-wikipedia-org-4107	832	17	preferential	preferential	JJ
en-wikipedia-org-4107	832	18	elevation	elevation	NN
en-wikipedia-org-4107	832	19	of	of	IN
en-wikipedia-org-4107	832	20	catecholamines	catecholamine	NNS
en-wikipedia-org-4107	832	21	in	in	IN
en-wikipedia-org-4107	832	22	the	the	DT
en-wikipedia-org-4107	832	23	PFC	PFC	NNP
en-wikipedia-org-4107	832	24	and	and	CC
en-wikipedia-org-4107	832	25	the	the	DT
en-wikipedia-org-4107	832	26	subsequent	subsequent	JJ
en-wikipedia-org-4107	832	27	activation	activation	NN
en-wikipedia-org-4107	832	28	of	of	IN
en-wikipedia-org-4107	832	29	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	832	30	α2	α2	NNP
en-wikipedia-org-4107	832	31	and	and	CC
en-wikipedia-org-4107	832	32	dopamine	dopamine	NNP
en-wikipedia-org-4107	832	33	D1	D1	NNP
en-wikipedia-org-4107	832	34	receptors	receptor	NNS
en-wikipedia-org-4107	832	35	.	.	.
en-wikipedia-org-4107	833	1	...	...	NFP
en-wikipedia-org-4107	834	1	This	this	DT
en-wikipedia-org-4107	834	2	differential	differential	JJ
en-wikipedia-org-4107	834	3	modulation	modulation	NN
en-wikipedia-org-4107	834	4	of	of	IN
en-wikipedia-org-4107	834	5	PFC	PFC	NNP
en-wikipedia-org-4107	834	6	-	-	HYPH
en-wikipedia-org-4107	834	7	dependent	dependent	JJ
en-wikipedia-org-4107	834	8	processes	process	NNS
en-wikipedia-org-4107	834	9	across	across	IN
en-wikipedia-org-4107	834	10	dose	dose	VB
en-wikipedia-org-4107	834	11	appears	appear	NNS
en-wikipedia-org-4107	834	12	to	to	TO
en-wikipedia-org-4107	834	13	be	be	VB
en-wikipedia-org-4107	834	14	associated	associate	VBN
en-wikipedia-org-4107	834	15	with	with	IN
en-wikipedia-org-4107	834	16	the	the	DT
en-wikipedia-org-4107	834	17	differential	differential	JJ
en-wikipedia-org-4107	834	18	involvement	involvement	NN
en-wikipedia-org-4107	834	19	of	of	IN
en-wikipedia-org-4107	834	20	noradrenergic	noradrenergic	NNP
en-wikipedia-org-4107	834	21	α2	α2	NNP
en-wikipedia-org-4107	834	22	versus	versus	IN
en-wikipedia-org-4107	834	23	α1	α1	NNP
en-wikipedia-org-4107	834	24	receptors	receptor	NNS
en-wikipedia-org-4107	834	25	.	.	.
en-wikipedia-org-4107	835	1	Collectively	collectively	RB
en-wikipedia-org-4107	835	2	,	,	,
en-wikipedia-org-4107	835	3	this	this	DT
en-wikipedia-org-4107	835	4	evidence	evidence	NN
en-wikipedia-org-4107	835	5	indicates	indicate	VBZ
en-wikipedia-org-4107	835	6	that	that	IN
en-wikipedia-org-4107	835	7	at	at	RB
en-wikipedia-org-4107	835	8	low	low	JJ
en-wikipedia-org-4107	835	9	,	,	,
en-wikipedia-org-4107	835	10	clinically	clinically	RB
en-wikipedia-org-4107	835	11	relevant	relevant	JJ
en-wikipedia-org-4107	835	12	doses	dose	NNS
en-wikipedia-org-4107	835	13	,	,	,
en-wikipedia-org-4107	835	14	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	835	15	are	be	VBP
en-wikipedia-org-4107	835	16	devoid	devoid	JJ
en-wikipedia-org-4107	835	17	of	of	IN
en-wikipedia-org-4107	835	18	the	the	DT
en-wikipedia-org-4107	835	19	behavioral	behavioral	JJ
en-wikipedia-org-4107	835	20	and	and	CC
en-wikipedia-org-4107	835	21	neurochemical	neurochemical	JJ
en-wikipedia-org-4107	835	22	actions	action	NNS
en-wikipedia-org-4107	835	23	that	that	WDT
en-wikipedia-org-4107	835	24	define	define	VBP
en-wikipedia-org-4107	835	25	this	this	DT
en-wikipedia-org-4107	835	26	class	class	NN
en-wikipedia-org-4107	835	27	of	of	IN
en-wikipedia-org-4107	835	28	drugs	drug	NNS
en-wikipedia-org-4107	835	29	and	and	CC
en-wikipedia-org-4107	835	30	instead	instead	RB
en-wikipedia-org-4107	835	31	act	act	VB
en-wikipedia-org-4107	835	32	largely	largely	RB
en-wikipedia-org-4107	835	33	as	as	IN
en-wikipedia-org-4107	835	34	cognitive	cognitive	JJ
en-wikipedia-org-4107	835	35	enhancers	enhancer	NNS
en-wikipedia-org-4107	835	36	(	(	-LRB-
en-wikipedia-org-4107	835	37	improving	improve	VBG
en-wikipedia-org-4107	835	38	PFC	PFC	NNP
en-wikipedia-org-4107	835	39	-	-	HYPH
en-wikipedia-org-4107	835	40	dependent	dependent	JJ
en-wikipedia-org-4107	835	41	function	function	NN
en-wikipedia-org-4107	835	42	)	)	-RRB-
en-wikipedia-org-4107	835	43	.	.	.
en-wikipedia-org-4107	836	1	...	...	NFP
en-wikipedia-org-4107	837	1	In	in	IN
en-wikipedia-org-4107	837	2	particular	particular	JJ
en-wikipedia-org-4107	837	3	,	,	,
en-wikipedia-org-4107	837	4	in	in	IN
en-wikipedia-org-4107	837	5	both	both	DT
en-wikipedia-org-4107	837	6	animals	animal	NNS
en-wikipedia-org-4107	837	7	and	and	CC
en-wikipedia-org-4107	837	8	humans	human	NNS
en-wikipedia-org-4107	837	9	,	,	,
en-wikipedia-org-4107	837	10	lower	low	JJR
en-wikipedia-org-4107	837	11	doses	dose	NNS
en-wikipedia-org-4107	837	12	maximally	maximally	RB
en-wikipedia-org-4107	837	13	improve	improve	VB
en-wikipedia-org-4107	837	14	performance	performance	NN
en-wikipedia-org-4107	837	15	in	in	IN
en-wikipedia-org-4107	837	16	tests	test	NNS
en-wikipedia-org-4107	837	17	of	of	IN
en-wikipedia-org-4107	837	18	working	work	VBG
en-wikipedia-org-4107	837	19	memory	memory	NN
en-wikipedia-org-4107	837	20	and	and	CC
en-wikipedia-org-4107	837	21	response	response	NN
en-wikipedia-org-4107	837	22	inhibition	inhibition	NN
en-wikipedia-org-4107	837	23	,	,	,
en-wikipedia-org-4107	837	24	whereas	whereas	IN
en-wikipedia-org-4107	837	25	maximal	maximal	JJ
en-wikipedia-org-4107	837	26	suppression	suppression	NN
en-wikipedia-org-4107	837	27	of	of	IN
en-wikipedia-org-4107	837	28	overt	overt	JJ
en-wikipedia-org-4107	837	29	behavior	behavior	NN
en-wikipedia-org-4107	837	30	and	and	CC
en-wikipedia-org-4107	837	31	facilitation	facilitation	NN
en-wikipedia-org-4107	837	32	of	of	IN
en-wikipedia-org-4107	837	33	attentional	attentional	JJ
en-wikipedia-org-4107	837	34	processes	process	NNS
en-wikipedia-org-4107	837	35	occurs	occur	VBZ
en-wikipedia-org-4107	837	36	at	at	IN
en-wikipedia-org-4107	837	37	higher	high	JJR
en-wikipedia-org-4107	837	38	doses	dose	NNS
en-wikipedia-org-4107	837	39	.	.	.
en-wikipedia-org-4107	838	1	^	^	NFP
en-wikipedia-org-4107	838	2	Ilieva	Ilieva	NNP
en-wikipedia-org-4107	838	3	IP	IP	NNP
en-wikipedia-org-4107	838	4	,	,	,
en-wikipedia-org-4107	838	5	Hook	Hook	NNP
en-wikipedia-org-4107	838	6	CJ	CJ	NNP
en-wikipedia-org-4107	838	7	,	,	,
en-wikipedia-org-4107	838	8	Farah	Farah	NNP
en-wikipedia-org-4107	838	9	MJ	MJ	NNP
en-wikipedia-org-4107	838	10	(	(	-LRB-
en-wikipedia-org-4107	838	11	June	June	NNP
en-wikipedia-org-4107	838	12	2015	2015	CD
en-wikipedia-org-4107	838	13	)	)	-RRB-
en-wikipedia-org-4107	838	14	.	.	.
en-wikipedia-org-4107	839	1	"	"	``
en-wikipedia-org-4107	839	2	Prescription	Prescription	NNP
en-wikipedia-org-4107	839	3	Stimulants	Stimulants	NNPS
en-wikipedia-org-4107	839	4	'	'	POS
en-wikipedia-org-4107	839	5	Effects	effect	NNS
en-wikipedia-org-4107	839	6	on	on	IN
en-wikipedia-org-4107	839	7	Healthy	Healthy	NNP
en-wikipedia-org-4107	839	8	Inhibitory	Inhibitory	NNP
en-wikipedia-org-4107	839	9	Control	Control	NNP
en-wikipedia-org-4107	839	10	,	,	,
en-wikipedia-org-4107	839	11	Working	Working	NNP
en-wikipedia-org-4107	839	12	Memory	Memory	NNP
en-wikipedia-org-4107	839	13	,	,	,
en-wikipedia-org-4107	839	14	and	and	CC
en-wikipedia-org-4107	839	15	Episodic	episodic	JJ
en-wikipedia-org-4107	839	16	Memory	Memory	NNP
en-wikipedia-org-4107	839	17	:	:	:
en-wikipedia-org-4107	839	18	A	a	DT
en-wikipedia-org-4107	839	19	Meta	Meta	NNP
en-wikipedia-org-4107	839	20	-	-	HYPH
en-wikipedia-org-4107	839	21	analysis	analysis	NN
en-wikipedia-org-4107	839	22	"	"	''
en-wikipedia-org-4107	839	23	.	.	.
en-wikipedia-org-4107	840	1	Journal	Journal	NNP
en-wikipedia-org-4107	840	2	of	of	IN
en-wikipedia-org-4107	840	3	Cognitive	Cognitive	NNP
en-wikipedia-org-4107	840	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	840	5	.	.	.
en-wikipedia-org-4107	841	1	27	27	CD
en-wikipedia-org-4107	841	2	(	(	-LRB-
en-wikipedia-org-4107	841	3	6	6	CD
en-wikipedia-org-4107	841	4	)	)	-RRB-
en-wikipedia-org-4107	841	5	:	:	:
en-wikipedia-org-4107	841	6	1069–1089	1069–1089	CD
en-wikipedia-org-4107	841	7	.	.	.
en-wikipedia-org-4107	842	1	doi:10.1162	doi:10.1162	VB
en-wikipedia-org-4107	842	2	/	/	SYM
en-wikipedia-org-4107	842	3	jocn_a_00776	jocn_a_00776	ADD
en-wikipedia-org-4107	842	4	.	.	.
en-wikipedia-org-4107	843	1	PMID	PMID	NNP
en-wikipedia-org-4107	843	2	 	  	_SP
en-wikipedia-org-4107	843	3	25591060	25591060	CD
en-wikipedia-org-4107	843	4	.	.	.
en-wikipedia-org-4107	844	1	S2CID	S2CID	NNP
en-wikipedia-org-4107	844	2	 	  	_SP
en-wikipedia-org-4107	844	3	15788121	15788121	CD
en-wikipedia-org-4107	844	4	.	.	.
en-wikipedia-org-4107	845	1	Specifically	specifically	RB
en-wikipedia-org-4107	845	2	,	,	,
en-wikipedia-org-4107	845	3	in	in	IN
en-wikipedia-org-4107	845	4	a	a	DT
en-wikipedia-org-4107	845	5	set	set	NN
en-wikipedia-org-4107	845	6	of	of	IN
en-wikipedia-org-4107	845	7	experiments	experiment	NNS
en-wikipedia-org-4107	845	8	limited	limit	VBN
en-wikipedia-org-4107	845	9	to	to	IN
en-wikipedia-org-4107	845	10	high	high	JJ
en-wikipedia-org-4107	845	11	-	-	HYPH
en-wikipedia-org-4107	845	12	quality	quality	NN
en-wikipedia-org-4107	845	13	designs	design	NNS
en-wikipedia-org-4107	845	14	,	,	,
en-wikipedia-org-4107	845	15	we	-PRON-	PRP
en-wikipedia-org-4107	845	16	found	find	VBD
en-wikipedia-org-4107	845	17	significant	significant	JJ
en-wikipedia-org-4107	845	18	enhancement	enhancement	NN
en-wikipedia-org-4107	845	19	of	of	IN
en-wikipedia-org-4107	845	20	several	several	JJ
en-wikipedia-org-4107	845	21	cognitive	cognitive	JJ
en-wikipedia-org-4107	845	22	abilities	ability	NNS
en-wikipedia-org-4107	845	23	.	.	.
en-wikipedia-org-4107	846	1	...	...	NFP
en-wikipedia-org-4107	847	1	The	the	DT
en-wikipedia-org-4107	847	2	results	result	NNS
en-wikipedia-org-4107	847	3	of	of	IN
en-wikipedia-org-4107	847	4	this	this	DT
en-wikipedia-org-4107	847	5	meta	meta	JJ
en-wikipedia-org-4107	847	6	-	-	HYPH
en-wikipedia-org-4107	847	7	analysis	analysis	NN
en-wikipedia-org-4107	847	8	 	  	_SP
en-wikipedia-org-4107	847	9	...	...	:
en-wikipedia-org-4107	847	10	do	do	VBP
en-wikipedia-org-4107	847	11	confirm	confirm	VB
en-wikipedia-org-4107	847	12	the	the	DT
en-wikipedia-org-4107	847	13	reality	reality	NN
en-wikipedia-org-4107	847	14	of	of	IN
en-wikipedia-org-4107	847	15	cognitive	cognitive	JJ
en-wikipedia-org-4107	847	16	enhancing	enhance	VBG
en-wikipedia-org-4107	847	17	effects	effect	NNS
en-wikipedia-org-4107	847	18	for	for	IN
en-wikipedia-org-4107	847	19	normal	normal	JJ
en-wikipedia-org-4107	847	20	healthy	healthy	JJ
en-wikipedia-org-4107	847	21	adults	adult	NNS
en-wikipedia-org-4107	847	22	in	in	IN
en-wikipedia-org-4107	847	23	general	general	JJ
en-wikipedia-org-4107	847	24	,	,	,
en-wikipedia-org-4107	847	25	while	while	IN
en-wikipedia-org-4107	847	26	also	also	RB
en-wikipedia-org-4107	847	27	indicating	indicate	VBG
en-wikipedia-org-4107	847	28	that	that	IN
en-wikipedia-org-4107	847	29	these	these	DT
en-wikipedia-org-4107	847	30	effects	effect	NNS
en-wikipedia-org-4107	847	31	are	be	VBP
en-wikipedia-org-4107	847	32	modest	modest	JJ
en-wikipedia-org-4107	847	33	in	in	IN
en-wikipedia-org-4107	847	34	size	size	NN
en-wikipedia-org-4107	847	35	.	.	.
en-wikipedia-org-4107	848	1	^	^	NNP
en-wikipedia-org-4107	848	2	Bagot	Bagot	NNP
en-wikipedia-org-4107	848	3	KS	KS	NNP
en-wikipedia-org-4107	848	4	,	,	,
en-wikipedia-org-4107	848	5	Kaminer	Kaminer	NNP
en-wikipedia-org-4107	848	6	Y	Y	NNP
en-wikipedia-org-4107	848	7	(	(	-LRB-
en-wikipedia-org-4107	848	8	April	April	NNP
en-wikipedia-org-4107	848	9	2014	2014	CD
en-wikipedia-org-4107	848	10	)	)	-RRB-
en-wikipedia-org-4107	848	11	.	.	.
en-wikipedia-org-4107	849	1	"	"	``
en-wikipedia-org-4107	849	2	Efficacy	efficacy	NN
en-wikipedia-org-4107	849	3	of	of	IN
en-wikipedia-org-4107	849	4	stimulants	stimulant	NNS
en-wikipedia-org-4107	849	5	for	for	IN
en-wikipedia-org-4107	849	6	cognitive	cognitive	JJ
en-wikipedia-org-4107	849	7	enhancement	enhancement	NN
en-wikipedia-org-4107	849	8	in	in	IN
en-wikipedia-org-4107	849	9	non	non	JJ
en-wikipedia-org-4107	849	10	-	-	JJ
en-wikipedia-org-4107	849	11	attention	attention	JJ
en-wikipedia-org-4107	849	12	deficit	deficit	NN
en-wikipedia-org-4107	849	13	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	849	14	disorder	disorder	NN
en-wikipedia-org-4107	849	15	youth	youth	NN
en-wikipedia-org-4107	849	16	:	:	:
en-wikipedia-org-4107	849	17	a	a	DT
en-wikipedia-org-4107	849	18	systematic	systematic	JJ
en-wikipedia-org-4107	849	19	review	review	NN
en-wikipedia-org-4107	849	20	"	"	''
en-wikipedia-org-4107	849	21	.	.	.
en-wikipedia-org-4107	850	1	Addiction	addiction	NN
en-wikipedia-org-4107	850	2	.	.	.
en-wikipedia-org-4107	851	1	109	109	CD
en-wikipedia-org-4107	851	2	(	(	-LRB-
en-wikipedia-org-4107	851	3	4	4	CD
en-wikipedia-org-4107	851	4	)	)	-RRB-
en-wikipedia-org-4107	851	5	:	:	:
en-wikipedia-org-4107	851	6	547–557	547–557	CD
en-wikipedia-org-4107	851	7	.	.	.
en-wikipedia-org-4107	852	1	doi:10.1111	doi:10.1111	NN
en-wikipedia-org-4107	852	2	/	/	SYM
en-wikipedia-org-4107	852	3	add.12460	add.12460	NN
en-wikipedia-org-4107	852	4	.	.	.
en-wikipedia-org-4107	853	1	PMC	PMC	NNP
en-wikipedia-org-4107	853	2	 	  	_SP
en-wikipedia-org-4107	853	3	4471173	4471173	CD
en-wikipedia-org-4107	853	4	.	.	.
en-wikipedia-org-4107	854	1	PMID	PMID	NNP
en-wikipedia-org-4107	854	2	 	  	_SP
en-wikipedia-org-4107	854	3	24749160	24749160	CD
en-wikipedia-org-4107	854	4	.	.	.
en-wikipedia-org-4107	855	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	855	2	has	have	VBZ
en-wikipedia-org-4107	855	3	been	be	VBN
en-wikipedia-org-4107	855	4	shown	show	VBN
en-wikipedia-org-4107	855	5	to	to	TO
en-wikipedia-org-4107	855	6	improve	improve	VB
en-wikipedia-org-4107	855	7	consolidation	consolidation	NN
en-wikipedia-org-4107	855	8	of	of	IN
en-wikipedia-org-4107	855	9	information	information	NN
en-wikipedia-org-4107	855	10	(	(	-LRB-
en-wikipedia-org-4107	855	11	0.02	0.02	CD
en-wikipedia-org-4107	855	12	 	  	_SP
en-wikipedia-org-4107	855	13	≥	≥	UH
en-wikipedia-org-4107	855	14	 	  	_SP
en-wikipedia-org-4107	855	15	P	p	NN
en-wikipedia-org-4107	855	16	 	  	_SP
en-wikipedia-org-4107	855	17	≤	≤	NN
en-wikipedia-org-4107	855	18	 	  	_SP
en-wikipedia-org-4107	855	19	0.05	0.05	CD
en-wikipedia-org-4107	855	20	)	)	-RRB-
en-wikipedia-org-4107	855	21	,	,	,
en-wikipedia-org-4107	855	22	leading	lead	VBG
en-wikipedia-org-4107	855	23	to	to	IN
en-wikipedia-org-4107	855	24	improved	improved	JJ
en-wikipedia-org-4107	855	25	recall	recall	NN
en-wikipedia-org-4107	855	26	.	.	.
en-wikipedia-org-4107	856	1	^	^	NNP
en-wikipedia-org-4107	856	2	Devous	devous	JJ
en-wikipedia-org-4107	856	3	MD	MD	NNP
en-wikipedia-org-4107	856	4	,	,	,
en-wikipedia-org-4107	856	5	Trivedi	Trivedi	NNP
en-wikipedia-org-4107	856	6	MH	MH	NNP
en-wikipedia-org-4107	856	7	,	,	,
en-wikipedia-org-4107	856	8	Rush	Rush	NNP
en-wikipedia-org-4107	856	9	AJ	AJ	NNP
en-wikipedia-org-4107	856	10	(	(	-LRB-
en-wikipedia-org-4107	856	11	April	April	NNP
en-wikipedia-org-4107	856	12	2001	2001	CD
en-wikipedia-org-4107	856	13	)	)	-RRB-
en-wikipedia-org-4107	856	14	.	.	.
en-wikipedia-org-4107	857	1	"	"	``
en-wikipedia-org-4107	857	2	Regional	regional	JJ
en-wikipedia-org-4107	857	3	cerebral	cerebral	JJ
en-wikipedia-org-4107	857	4	blood	blood	NN
en-wikipedia-org-4107	857	5	flow	flow	NN
en-wikipedia-org-4107	857	6	response	response	NN
en-wikipedia-org-4107	857	7	to	to	IN
en-wikipedia-org-4107	857	8	oral	oral	NNP
en-wikipedia-org-4107	857	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	857	10	challenge	challenge	NN
en-wikipedia-org-4107	857	11	in	in	IN
en-wikipedia-org-4107	857	12	healthy	healthy	JJ
en-wikipedia-org-4107	857	13	volunteers	volunteer	NNS
en-wikipedia-org-4107	857	14	"	"	''
en-wikipedia-org-4107	857	15	.	.	.
en-wikipedia-org-4107	858	1	Journal	Journal	NNP
en-wikipedia-org-4107	858	2	of	of	IN
en-wikipedia-org-4107	858	3	Nuclear	Nuclear	NNP
en-wikipedia-org-4107	858	4	Medicine	Medicine	NNP
en-wikipedia-org-4107	858	5	.	.	.
en-wikipedia-org-4107	859	1	42	42	CD
en-wikipedia-org-4107	859	2	(	(	-LRB-
en-wikipedia-org-4107	859	3	4	4	CD
en-wikipedia-org-4107	859	4	)	)	-RRB-
en-wikipedia-org-4107	859	5	:	:	:
en-wikipedia-org-4107	859	6	535–542	535–542	CD
en-wikipedia-org-4107	859	7	.	.	.
en-wikipedia-org-4107	860	1	PMID	PMID	NNP
en-wikipedia-org-4107	860	2	 	  	_SP
en-wikipedia-org-4107	860	3	11337538	11337538	CD
en-wikipedia-org-4107	860	4	.	.	.
en-wikipedia-org-4107	861	1	^	^	NNP
en-wikipedia-org-4107	861	2	Malenka	Malenka	NNP
en-wikipedia-org-4107	861	3	RC	RC	NNP
en-wikipedia-org-4107	861	4	,	,	,
en-wikipedia-org-4107	861	5	Nestler	Nestler	NNP
en-wikipedia-org-4107	861	6	EJ	EJ	NNP
en-wikipedia-org-4107	861	7	,	,	,
en-wikipedia-org-4107	861	8	Hyman	Hyman	NNP
en-wikipedia-org-4107	861	9	SE	SE	NNP
en-wikipedia-org-4107	861	10	(	(	-LRB-
en-wikipedia-org-4107	861	11	2009	2009	CD
en-wikipedia-org-4107	861	12	)	)	-RRB-
en-wikipedia-org-4107	861	13	.	.	.
en-wikipedia-org-4107	862	1	"	"	``
en-wikipedia-org-4107	862	2	Chapter	chapter	NN
en-wikipedia-org-4107	862	3	10	10	CD
en-wikipedia-org-4107	862	4	:	:	:
en-wikipedia-org-4107	862	5	Neural	neural	JJ
en-wikipedia-org-4107	862	6	and	and	CC
en-wikipedia-org-4107	862	7	Neuroendocrine	Neuroendocrine	NNP
en-wikipedia-org-4107	862	8	Control	Control	NNP
en-wikipedia-org-4107	862	9	of	of	IN
en-wikipedia-org-4107	862	10	the	the	DT
en-wikipedia-org-4107	862	11	Internal	Internal	NNP
en-wikipedia-org-4107	862	12	Milieu	Milieu	NNP
en-wikipedia-org-4107	862	13	"	"	''
en-wikipedia-org-4107	862	14	.	.	.
en-wikipedia-org-4107	863	1	In	in	IN
en-wikipedia-org-4107	863	2	Sydor	Sydor	NNP
en-wikipedia-org-4107	863	3	A	A	NNP
en-wikipedia-org-4107	863	4	,	,	,
en-wikipedia-org-4107	863	5	Brown	Brown	NNP
en-wikipedia-org-4107	863	6	RY	RY	NNP
en-wikipedia-org-4107	863	7	(	(	-LRB-
en-wikipedia-org-4107	863	8	eds	eds	NNP
en-wikipedia-org-4107	863	9	.	.	.
en-wikipedia-org-4107	863	10	)	)	-RRB-
en-wikipedia-org-4107	863	11	.	.	.
en-wikipedia-org-4107	864	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	864	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-4107	864	3	:	:	:
en-wikipedia-org-4107	864	4	A	A	NNP
en-wikipedia-org-4107	864	5	Foundation	Foundation	NNP
en-wikipedia-org-4107	864	6	for	for	IN
en-wikipedia-org-4107	864	7	Clinical	Clinical	NNP
en-wikipedia-org-4107	864	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	864	9	(	(	-LRB-
en-wikipedia-org-4107	864	10	2nd	2nd	NNP
en-wikipedia-org-4107	864	11	ed	ed	NNP
en-wikipedia-org-4107	864	12	.	.	.
en-wikipedia-org-4107	864	13	)	)	-RRB-
en-wikipedia-org-4107	864	14	.	.	.
en-wikipedia-org-4107	865	1	New	New	NNP
en-wikipedia-org-4107	865	2	York	York	NNP
en-wikipedia-org-4107	865	3	,	,	,
en-wikipedia-org-4107	865	4	USA	USA	NNP
en-wikipedia-org-4107	865	5	:	:	:
en-wikipedia-org-4107	865	6	McGraw	McGraw	NNP
en-wikipedia-org-4107	865	7	-	-	HYPH
en-wikipedia-org-4107	865	8	Hill	Hill	NNP
en-wikipedia-org-4107	865	9	Medical	Medical	NNP
en-wikipedia-org-4107	865	10	.	.	.
en-wikipedia-org-4107	866	1	p.	p.	NN
en-wikipedia-org-4107	866	2	 	  	_SP
en-wikipedia-org-4107	866	3	266	266	CD
en-wikipedia-org-4107	866	4	.	.	.
en-wikipedia-org-4107	867	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	867	2	 	  	_SP
en-wikipedia-org-4107	867	3	9780071481274	9780071481274	CD
en-wikipedia-org-4107	867	4	.	.	.
en-wikipedia-org-4107	868	1	Dopamine	dopamine	NN
en-wikipedia-org-4107	868	2	acts	act	VBZ
en-wikipedia-org-4107	868	3	in	in	IN
en-wikipedia-org-4107	868	4	the	the	DT
en-wikipedia-org-4107	868	5	nucleus	nucleus	NN
en-wikipedia-org-4107	868	6	accumbens	accumben	VBZ
en-wikipedia-org-4107	868	7	to	to	TO
en-wikipedia-org-4107	868	8	attach	attach	VB
en-wikipedia-org-4107	868	9	motivational	motivational	JJ
en-wikipedia-org-4107	868	10	significance	significance	NN
en-wikipedia-org-4107	868	11	to	to	IN
en-wikipedia-org-4107	868	12	stimuli	stimulus	NNS
en-wikipedia-org-4107	868	13	associated	associate	VBN
en-wikipedia-org-4107	868	14	with	with	IN
en-wikipedia-org-4107	868	15	reward	reward	NN
en-wikipedia-org-4107	868	16	.	.	.
en-wikipedia-org-4107	869	1	^	^	NNP
en-wikipedia-org-4107	869	2	a	a	DT
en-wikipedia-org-4107	869	3	b	b	NN
en-wikipedia-org-4107	869	4	c	c	NN
en-wikipedia-org-4107	869	5	Wood	Wood	NNP
en-wikipedia-org-4107	869	6	S	S	NNP
en-wikipedia-org-4107	869	7	,	,	,
en-wikipedia-org-4107	869	8	Sage	Sage	NNP
en-wikipedia-org-4107	869	9	JR	JR	NNP
en-wikipedia-org-4107	869	10	,	,	,
en-wikipedia-org-4107	869	11	Shuman	Shuman	NNP
en-wikipedia-org-4107	869	12	T	T	NNP
en-wikipedia-org-4107	869	13	,	,	,
en-wikipedia-org-4107	869	14	Anagnostaras	Anagnostaras	NNP
en-wikipedia-org-4107	869	15	SG	SG	NNP
en-wikipedia-org-4107	869	16	(	(	-LRB-
en-wikipedia-org-4107	869	17	January	January	NNP
en-wikipedia-org-4107	869	18	2014	2014	CD
en-wikipedia-org-4107	869	19	)	)	-RRB-
en-wikipedia-org-4107	869	20	.	.	.
en-wikipedia-org-4107	870	1	"	"	``
en-wikipedia-org-4107	870	2	Psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	870	3	and	and	CC
en-wikipedia-org-4107	870	4	cognition	cognition	NN
en-wikipedia-org-4107	870	5	:	:	:
en-wikipedia-org-4107	870	6	a	a	DT
en-wikipedia-org-4107	870	7	continuum	continuum	NN
en-wikipedia-org-4107	870	8	of	of	IN
en-wikipedia-org-4107	870	9	behavioral	behavioral	JJ
en-wikipedia-org-4107	870	10	and	and	CC
en-wikipedia-org-4107	870	11	cognitive	cognitive	JJ
en-wikipedia-org-4107	870	12	activation	activation	NN
en-wikipedia-org-4107	870	13	"	"	''
en-wikipedia-org-4107	870	14	.	.	.
en-wikipedia-org-4107	871	1	Pharmacological	Pharmacological	NNP
en-wikipedia-org-4107	871	2	Reviews	Reviews	NNPS
en-wikipedia-org-4107	871	3	.	.	.
en-wikipedia-org-4107	872	1	66	66	CD
en-wikipedia-org-4107	872	2	(	(	-LRB-
en-wikipedia-org-4107	872	3	1	1	CD
en-wikipedia-org-4107	872	4	)	)	-RRB-
en-wikipedia-org-4107	872	5	:	:	:
en-wikipedia-org-4107	872	6	193–221	193–221	CD
en-wikipedia-org-4107	872	7	.	.	.
en-wikipedia-org-4107	873	1	doi:10.1124	doi:10.1124	NNP
en-wikipedia-org-4107	873	2	/	/	SYM
en-wikipedia-org-4107	873	3	pr.112.007054	pr.112.007054	NNP
en-wikipedia-org-4107	873	4	.	.	.
en-wikipedia-org-4107	874	1	PMC	PMC	NNP
en-wikipedia-org-4107	874	2	 	  	_SP
en-wikipedia-org-4107	874	3	3880463	3880463	CD
en-wikipedia-org-4107	874	4	.	.	.
en-wikipedia-org-4107	875	1	PMID	PMID	NNP
en-wikipedia-org-4107	875	2	 	  	_SP
en-wikipedia-org-4107	875	3	24344115	24344115	CD
en-wikipedia-org-4107	875	4	.	.	.
en-wikipedia-org-4107	876	1	^	^	NFP
en-wikipedia-org-4107	876	2	Twohey	Twohey	NNP
en-wikipedia-org-4107	876	3	M	M	NNP
en-wikipedia-org-4107	876	4	(	(	-LRB-
en-wikipedia-org-4107	876	5	26	26	CD
en-wikipedia-org-4107	876	6	March	March	NNP
en-wikipedia-org-4107	876	7	2006	2006	CD
en-wikipedia-org-4107	876	8	)	)	-RRB-
en-wikipedia-org-4107	876	9	.	.	.
en-wikipedia-org-4107	877	1	"	"	``
en-wikipedia-org-4107	877	2	Pills	pill	NNS
en-wikipedia-org-4107	877	3	become	become	VBP
en-wikipedia-org-4107	877	4	an	an	DT
en-wikipedia-org-4107	877	5	addictive	addictive	JJ
en-wikipedia-org-4107	877	6	study	study	NN
en-wikipedia-org-4107	877	7	aid	aid	NN
en-wikipedia-org-4107	877	8	"	"	''
en-wikipedia-org-4107	877	9	.	.	.
en-wikipedia-org-4107	878	1	JS	JS	NNP
en-wikipedia-org-4107	878	2	Online	Online	NNP
en-wikipedia-org-4107	878	3	.	.	.
en-wikipedia-org-4107	879	1	Archived	archived	JJ
en-wikipedia-org-4107	879	2	from	from	IN
en-wikipedia-org-4107	879	3	the	the	DT
en-wikipedia-org-4107	879	4	original	original	NN
en-wikipedia-org-4107	879	5	on	on	IN
en-wikipedia-org-4107	879	6	15	15	CD
en-wikipedia-org-4107	879	7	August	August	NNP
en-wikipedia-org-4107	879	8	2007	2007	CD
en-wikipedia-org-4107	879	9	.	.	.
en-wikipedia-org-4107	880	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	880	2	2	2	CD
en-wikipedia-org-4107	880	3	December	December	NNP
en-wikipedia-org-4107	880	4	2007	2007	CD
en-wikipedia-org-4107	880	5	.	.	.
en-wikipedia-org-4107	881	1	^	^	NNP
en-wikipedia-org-4107	881	2	Teter	Teter	NNP
en-wikipedia-org-4107	881	3	CJ	CJ	NNP
en-wikipedia-org-4107	881	4	,	,	,
en-wikipedia-org-4107	881	5	McCabe	McCabe	NNP
en-wikipedia-org-4107	881	6	SE	SE	NNP
en-wikipedia-org-4107	881	7	,	,	,
en-wikipedia-org-4107	881	8	LaGrange	LaGrange	NNP
en-wikipedia-org-4107	881	9	K	K	NNP
en-wikipedia-org-4107	881	10	,	,	,
en-wikipedia-org-4107	881	11	Cranford	Cranford	NNP
en-wikipedia-org-4107	881	12	JA	JA	NNP
en-wikipedia-org-4107	881	13	,	,	,
en-wikipedia-org-4107	881	14	Boyd	Boyd	NNP
en-wikipedia-org-4107	881	15	CJ	CJ	NNP
en-wikipedia-org-4107	881	16	(	(	-LRB-
en-wikipedia-org-4107	881	17	October	October	NNP
en-wikipedia-org-4107	881	18	2006	2006	CD
en-wikipedia-org-4107	881	19	)	)	-RRB-
en-wikipedia-org-4107	881	20	.	.	.
en-wikipedia-org-4107	882	1	"	"	``
en-wikipedia-org-4107	882	2	Illicit	illicit	JJ
en-wikipedia-org-4107	882	3	use	use	VBP
en-wikipedia-org-4107	882	4	of	of	IN
en-wikipedia-org-4107	882	5	specific	specific	JJ
en-wikipedia-org-4107	882	6	prescription	prescription	NN
en-wikipedia-org-4107	882	7	stimulants	stimulant	NNS
en-wikipedia-org-4107	882	8	among	among	IN
en-wikipedia-org-4107	882	9	college	college	NN
en-wikipedia-org-4107	882	10	students	student	NNS
en-wikipedia-org-4107	882	11	:	:	:
en-wikipedia-org-4107	882	12	prevalence	prevalence	NN
en-wikipedia-org-4107	882	13	,	,	,
en-wikipedia-org-4107	882	14	motives	motive	NNS
en-wikipedia-org-4107	882	15	,	,	,
en-wikipedia-org-4107	882	16	and	and	CC
en-wikipedia-org-4107	882	17	routes	route	NNS
en-wikipedia-org-4107	882	18	of	of	IN
en-wikipedia-org-4107	882	19	administration	administration	NN
en-wikipedia-org-4107	882	20	"	"	''
en-wikipedia-org-4107	882	21	.	.	.
en-wikipedia-org-4107	883	1	Pharmacotherapy	Pharmacotherapy	NNP
en-wikipedia-org-4107	883	2	.	.	.
en-wikipedia-org-4107	884	1	26	26	CD
en-wikipedia-org-4107	884	2	(	(	-LRB-
en-wikipedia-org-4107	884	3	10	10	CD
en-wikipedia-org-4107	884	4	)	)	-RRB-
en-wikipedia-org-4107	884	5	:	:	:
en-wikipedia-org-4107	884	6	1501–1510	1501–1510	CD
en-wikipedia-org-4107	884	7	.	.	.
en-wikipedia-org-4107	885	1	doi:10.1592	doi:10.1592	NNP
en-wikipedia-org-4107	885	2	/	/	SYM
en-wikipedia-org-4107	885	3	phco.26.10.1501	phco.26.10.1501	NNP
en-wikipedia-org-4107	885	4	.	.	.
en-wikipedia-org-4107	886	1	PMC	PMC	NNP
en-wikipedia-org-4107	886	2	 	  	_SP
en-wikipedia-org-4107	886	3	1794223	1794223	CD
en-wikipedia-org-4107	886	4	.	.	.
en-wikipedia-org-4107	887	1	PMID	PMID	NNP
en-wikipedia-org-4107	887	2	 	  	_SP
en-wikipedia-org-4107	887	3	16999660	16999660	CD
en-wikipedia-org-4107	887	4	.	.	.
en-wikipedia-org-4107	888	1	^	^	NNP
en-wikipedia-org-4107	888	2	Weyandt	Weyandt	NNP
en-wikipedia-org-4107	888	3	LL	LL	NNP
en-wikipedia-org-4107	888	4	,	,	,
en-wikipedia-org-4107	888	5	Oster	Oster	NNP
en-wikipedia-org-4107	888	6	DR	DR	NNP
en-wikipedia-org-4107	888	7	,	,	,
en-wikipedia-org-4107	888	8	Marraccini	Marraccini	NNP
en-wikipedia-org-4107	888	9	ME	ME	NNP
en-wikipedia-org-4107	888	10	,	,	,
en-wikipedia-org-4107	888	11	Gudmundsdottir	Gudmundsdottir	NNP
en-wikipedia-org-4107	888	12	BG	BG	NNP
en-wikipedia-org-4107	888	13	,	,	,
en-wikipedia-org-4107	888	14	Munro	Munro	NNP
en-wikipedia-org-4107	888	15	BA	BA	NNP
en-wikipedia-org-4107	888	16	,	,	,
en-wikipedia-org-4107	888	17	Zavras	Zavras	NNP
en-wikipedia-org-4107	888	18	BM	BM	NNP
en-wikipedia-org-4107	888	19	,	,	,
en-wikipedia-org-4107	888	20	Kuhar	Kuhar	NNP
en-wikipedia-org-4107	888	21	B	B	NNP
en-wikipedia-org-4107	888	22	(	(	-LRB-
en-wikipedia-org-4107	888	23	September	September	NNP
en-wikipedia-org-4107	888	24	2014	2014	CD
en-wikipedia-org-4107	888	25	)	)	-RRB-
en-wikipedia-org-4107	888	26	.	.	.
en-wikipedia-org-4107	889	1	"	"	``
en-wikipedia-org-4107	889	2	Pharmacological	pharmacological	JJ
en-wikipedia-org-4107	889	3	interventions	intervention	NNS
en-wikipedia-org-4107	889	4	for	for	IN
en-wikipedia-org-4107	889	5	adolescents	adolescent	NNS
en-wikipedia-org-4107	889	6	and	and	CC
en-wikipedia-org-4107	889	7	adults	adult	NNS
en-wikipedia-org-4107	889	8	with	with	IN
en-wikipedia-org-4107	889	9	ADHD	ADHD	NNP
en-wikipedia-org-4107	889	10	:	:	:
en-wikipedia-org-4107	889	11	stimulant	stimulant	NN
en-wikipedia-org-4107	889	12	and	and	CC
en-wikipedia-org-4107	889	13	nonstimulant	nonstimulant	JJ
en-wikipedia-org-4107	889	14	medications	medication	NNS
en-wikipedia-org-4107	889	15	and	and	CC
en-wikipedia-org-4107	889	16	misuse	misuse	NN
en-wikipedia-org-4107	889	17	of	of	IN
en-wikipedia-org-4107	889	18	prescription	prescription	NN
en-wikipedia-org-4107	889	19	stimulants	stimulant	NNS
en-wikipedia-org-4107	889	20	"	"	''
en-wikipedia-org-4107	889	21	.	.	.
en-wikipedia-org-4107	890	1	Psychology	Psychology	NNP
en-wikipedia-org-4107	890	2	Research	Research	NNP
en-wikipedia-org-4107	890	3	and	and	CC
en-wikipedia-org-4107	890	4	Behavior	Behavior	NNP
en-wikipedia-org-4107	890	5	Management	Management	NNP
en-wikipedia-org-4107	890	6	.	.	.
en-wikipedia-org-4107	891	1	7	7	LS
en-wikipedia-org-4107	891	2	:	:	:
en-wikipedia-org-4107	891	3	223–249	223–249	CD
en-wikipedia-org-4107	891	4	.	.	.
en-wikipedia-org-4107	892	1	doi:10.2147	doi:10.2147	NNP
en-wikipedia-org-4107	892	2	/	/	SYM
en-wikipedia-org-4107	892	3	PRBM.S47013	PRBM.S47013	NNP
en-wikipedia-org-4107	892	4	.	.	.
en-wikipedia-org-4107	893	1	PMC	PMC	NNP
en-wikipedia-org-4107	893	2	 	  	_SP
en-wikipedia-org-4107	893	3	4164338	4164338	CD
en-wikipedia-org-4107	893	4	.	.	.
en-wikipedia-org-4107	894	1	PMID	PMID	NNP
en-wikipedia-org-4107	894	2	 	  	_SP
en-wikipedia-org-4107	894	3	25228824	25228824	CD
en-wikipedia-org-4107	894	4	.	.	.
en-wikipedia-org-4107	894	5	misuse	misuse	NN
en-wikipedia-org-4107	894	6	of	of	IN
en-wikipedia-org-4107	894	7	prescription	prescription	NN
en-wikipedia-org-4107	894	8	stimulants	stimulant	NNS
en-wikipedia-org-4107	894	9	has	have	VBZ
en-wikipedia-org-4107	894	10	become	become	VBN
en-wikipedia-org-4107	894	11	a	a	DT
en-wikipedia-org-4107	894	12	serious	serious	JJ
en-wikipedia-org-4107	894	13	problem	problem	NN
en-wikipedia-org-4107	894	14	on	on	IN
en-wikipedia-org-4107	894	15	college	college	NN
en-wikipedia-org-4107	894	16	campuses	campus	NNS
en-wikipedia-org-4107	894	17	across	across	IN
en-wikipedia-org-4107	894	18	the	the	DT
en-wikipedia-org-4107	894	19	US	US	NNP
en-wikipedia-org-4107	894	20	and	and	CC
en-wikipedia-org-4107	894	21	has	have	VBZ
en-wikipedia-org-4107	894	22	been	be	VBN
en-wikipedia-org-4107	894	23	recently	recently	RB
en-wikipedia-org-4107	894	24	documented	document	VBN
en-wikipedia-org-4107	894	25	in	in	IN
en-wikipedia-org-4107	894	26	other	other	JJ
en-wikipedia-org-4107	894	27	countries	country	NNS
en-wikipedia-org-4107	894	28	as	as	RB
en-wikipedia-org-4107	894	29	well	well	RB
en-wikipedia-org-4107	894	30	.	.	.
en-wikipedia-org-4107	895	1	...	...	NFP
en-wikipedia-org-4107	896	1	Indeed	indeed	RB
en-wikipedia-org-4107	896	2	,	,	,
en-wikipedia-org-4107	896	3	large	large	JJ
en-wikipedia-org-4107	896	4	numbers	number	NNS
en-wikipedia-org-4107	896	5	of	of	IN
en-wikipedia-org-4107	896	6	students	student	NNS
en-wikipedia-org-4107	896	7	claim	claim	VBP
en-wikipedia-org-4107	896	8	to	to	TO
en-wikipedia-org-4107	896	9	have	have	VB
en-wikipedia-org-4107	896	10	engaged	engage	VBN
en-wikipedia-org-4107	896	11	in	in	IN
en-wikipedia-org-4107	896	12	the	the	DT
en-wikipedia-org-4107	896	13	nonmedical	nonmedical	JJ
en-wikipedia-org-4107	896	14	use	use	NN
en-wikipedia-org-4107	896	15	of	of	IN
en-wikipedia-org-4107	896	16	prescription	prescription	NN
en-wikipedia-org-4107	896	17	stimulants	stimulant	NNS
en-wikipedia-org-4107	896	18	,	,	,
en-wikipedia-org-4107	896	19	which	which	WDT
en-wikipedia-org-4107	896	20	is	be	VBZ
en-wikipedia-org-4107	896	21	reflected	reflect	VBN
en-wikipedia-org-4107	896	22	in	in	IN
en-wikipedia-org-4107	896	23	lifetime	lifetime	NN
en-wikipedia-org-4107	896	24	prevalence	prevalence	NN
en-wikipedia-org-4107	896	25	rates	rate	NNS
en-wikipedia-org-4107	896	26	of	of	IN
en-wikipedia-org-4107	896	27	prescription	prescription	NN
en-wikipedia-org-4107	896	28	stimulant	stimulant	NN
en-wikipedia-org-4107	896	29	misuse	misuse	NN
en-wikipedia-org-4107	896	30	ranging	range	VBG
en-wikipedia-org-4107	896	31	from	from	IN
en-wikipedia-org-4107	896	32	5	5	CD
en-wikipedia-org-4107	896	33	%	%	NN
en-wikipedia-org-4107	896	34	to	to	IN
en-wikipedia-org-4107	896	35	nearly	nearly	RB
en-wikipedia-org-4107	896	36	34	34	CD
en-wikipedia-org-4107	896	37	%	%	NN
en-wikipedia-org-4107	896	38	of	of	IN
en-wikipedia-org-4107	896	39	students	student	NNS
en-wikipedia-org-4107	896	40	.	.	.
en-wikipedia-org-4107	897	1	^	^	NN
en-wikipedia-org-4107	897	2	Clemow	Clemow	NNP
en-wikipedia-org-4107	897	3	DB	DB	NNP
en-wikipedia-org-4107	897	4	,	,	,
en-wikipedia-org-4107	897	5	Walker	Walker	NNP
en-wikipedia-org-4107	897	6	DJ	DJ	NNP
en-wikipedia-org-4107	897	7	(	(	-LRB-
en-wikipedia-org-4107	897	8	September	September	NNP
en-wikipedia-org-4107	897	9	2014	2014	CD
en-wikipedia-org-4107	897	10	)	)	-RRB-
en-wikipedia-org-4107	897	11	.	.	.
en-wikipedia-org-4107	898	1	"	"	``
en-wikipedia-org-4107	898	2	The	the	DT
en-wikipedia-org-4107	898	3	potential	potential	NN
en-wikipedia-org-4107	898	4	for	for	IN
en-wikipedia-org-4107	898	5	misuse	misuse	NN
en-wikipedia-org-4107	898	6	and	and	CC
en-wikipedia-org-4107	898	7	abuse	abuse	NN
en-wikipedia-org-4107	898	8	of	of	IN
en-wikipedia-org-4107	898	9	medications	medication	NNS
en-wikipedia-org-4107	898	10	in	in	IN
en-wikipedia-org-4107	898	11	ADHD	ADHD	NNP
en-wikipedia-org-4107	898	12	:	:	:
en-wikipedia-org-4107	898	13	a	a	DT
en-wikipedia-org-4107	898	14	review	review	NN
en-wikipedia-org-4107	898	15	"	"	''
en-wikipedia-org-4107	898	16	.	.	.
en-wikipedia-org-4107	899	1	Postgraduate	Postgraduate	NNP
en-wikipedia-org-4107	899	2	Medicine	Medicine	NNP
en-wikipedia-org-4107	899	3	.	.	.
en-wikipedia-org-4107	900	1	126	126	CD
en-wikipedia-org-4107	900	2	(	(	-LRB-
en-wikipedia-org-4107	900	3	5	5	CD
en-wikipedia-org-4107	900	4	)	)	-RRB-
en-wikipedia-org-4107	900	5	:	:	:
en-wikipedia-org-4107	900	6	64–81	64–81	CD
en-wikipedia-org-4107	900	7	.	.	.
en-wikipedia-org-4107	901	1	doi:10.3810	doi:10.3810	NNP
en-wikipedia-org-4107	901	2	/	/	SYM
en-wikipedia-org-4107	901	3	pgm.2014.09.2801	pgm.2014.09.2801	NN
en-wikipedia-org-4107	901	4	.	.	.
en-wikipedia-org-4107	902	1	PMID	PMID	NNP
en-wikipedia-org-4107	902	2	 	  	_SP
en-wikipedia-org-4107	902	3	25295651	25295651	CD
en-wikipedia-org-4107	902	4	.	.	.
en-wikipedia-org-4107	903	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	903	2	 	  	_SP
en-wikipedia-org-4107	903	3	207580823	207580823	CD
en-wikipedia-org-4107	903	4	.	.	.
en-wikipedia-org-4107	904	1	Overall	overall	RB
en-wikipedia-org-4107	904	2	,	,	,
en-wikipedia-org-4107	904	3	the	the	DT
en-wikipedia-org-4107	904	4	data	datum	NNS
en-wikipedia-org-4107	904	5	suggest	suggest	VBP
en-wikipedia-org-4107	904	6	that	that	IN
en-wikipedia-org-4107	904	7	ADHD	ADHD	NNP
en-wikipedia-org-4107	904	8	medication	medication	NN
en-wikipedia-org-4107	904	9	misuse	misuse	NN
en-wikipedia-org-4107	904	10	and	and	CC
en-wikipedia-org-4107	904	11	diversion	diversion	NN
en-wikipedia-org-4107	904	12	are	be	VBP
en-wikipedia-org-4107	904	13	common	common	JJ
en-wikipedia-org-4107	904	14	health	health	NN
en-wikipedia-org-4107	904	15	care	care	NN
en-wikipedia-org-4107	904	16	problems	problem	NNS
en-wikipedia-org-4107	904	17	for	for	IN
en-wikipedia-org-4107	904	18	stimulant	stimulant	NN
en-wikipedia-org-4107	904	19	medications	medication	NNS
en-wikipedia-org-4107	904	20	,	,	,
en-wikipedia-org-4107	904	21	with	with	IN
en-wikipedia-org-4107	904	22	the	the	DT
en-wikipedia-org-4107	904	23	prevalence	prevalence	NN
en-wikipedia-org-4107	904	24	believed	believe	VBN
en-wikipedia-org-4107	904	25	to	to	TO
en-wikipedia-org-4107	904	26	be	be	VB
en-wikipedia-org-4107	904	27	approximately	approximately	RB
en-wikipedia-org-4107	904	28	5	5	CD
en-wikipedia-org-4107	904	29	%	%	NN
en-wikipedia-org-4107	904	30	to	to	TO
en-wikipedia-org-4107	904	31	10	10	CD
en-wikipedia-org-4107	904	32	%	%	NN
en-wikipedia-org-4107	904	33	of	of	IN
en-wikipedia-org-4107	904	34	high	high	JJ
en-wikipedia-org-4107	904	35	school	school	NN
en-wikipedia-org-4107	904	36	students	student	NNS
en-wikipedia-org-4107	904	37	and	and	CC
en-wikipedia-org-4107	904	38	5	5	CD
en-wikipedia-org-4107	904	39	%	%	NN
en-wikipedia-org-4107	904	40	to	to	TO
en-wikipedia-org-4107	904	41	35	35	CD
en-wikipedia-org-4107	904	42	%	%	NN
en-wikipedia-org-4107	904	43	of	of	IN
en-wikipedia-org-4107	904	44	college	college	NN
en-wikipedia-org-4107	904	45	students	student	NNS
en-wikipedia-org-4107	904	46	,	,	,
en-wikipedia-org-4107	904	47	depending	depend	VBG
en-wikipedia-org-4107	904	48	on	on	IN
en-wikipedia-org-4107	904	49	the	the	DT
en-wikipedia-org-4107	904	50	study	study	NN
en-wikipedia-org-4107	904	51	.	.	.
en-wikipedia-org-4107	905	1	^	^	NFP
en-wikipedia-org-4107	905	2	Bracken	Bracken	NNP
en-wikipedia-org-4107	905	3	NM	NM	NNP
en-wikipedia-org-4107	905	4	(	(	-LRB-
en-wikipedia-org-4107	905	5	January	January	NNP
en-wikipedia-org-4107	905	6	2012	2012	CD
en-wikipedia-org-4107	905	7	)	)	-RRB-
en-wikipedia-org-4107	905	8	.	.	.
en-wikipedia-org-4107	906	1	"	"	``
en-wikipedia-org-4107	906	2	National	National	NNP
en-wikipedia-org-4107	906	3	Study	Study	NNP
en-wikipedia-org-4107	906	4	of	of	IN
en-wikipedia-org-4107	906	5	Substance	Substance	NNP
en-wikipedia-org-4107	906	6	Use	Use	NNP
en-wikipedia-org-4107	906	7	Trends	Trends	NNP
en-wikipedia-org-4107	906	8	Among	among	IN
en-wikipedia-org-4107	906	9	NCAA	NCAA	NNP
en-wikipedia-org-4107	906	10	College	College	NNP
en-wikipedia-org-4107	906	11	Student	Student	NNP
en-wikipedia-org-4107	906	12	-	-	HYPH
en-wikipedia-org-4107	906	13	Athletes	Athletes	NNP
en-wikipedia-org-4107	906	14	"	"	''
en-wikipedia-org-4107	906	15	(	(	-LRB-
en-wikipedia-org-4107	906	16	PDF	PDF	NNP
en-wikipedia-org-4107	906	17	)	)	-RRB-
en-wikipedia-org-4107	906	18	.	.	.
en-wikipedia-org-4107	907	1	NCAA	NCAA	NNP
en-wikipedia-org-4107	907	2	Publications	Publications	NNP
en-wikipedia-org-4107	907	3	.	.	.
en-wikipedia-org-4107	908	1	National	National	NNP
en-wikipedia-org-4107	908	2	Collegiate	Collegiate	NNP
en-wikipedia-org-4107	908	3	Athletic	Athletic	NNP
en-wikipedia-org-4107	908	4	Association	Association	NNP
en-wikipedia-org-4107	908	5	.	.	.
en-wikipedia-org-4107	909	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	909	2	8	8	CD
en-wikipedia-org-4107	909	3	October	October	NNP
en-wikipedia-org-4107	909	4	2013	2013	CD
en-wikipedia-org-4107	909	5	.	.	.
en-wikipedia-org-4107	910	1	^	^	NNP
en-wikipedia-org-4107	910	2	Docherty	Docherty	NNP
en-wikipedia-org-4107	910	3	JR	JR	NNP
en-wikipedia-org-4107	910	4	(	(	-LRB-
en-wikipedia-org-4107	910	5	June	June	NNP
en-wikipedia-org-4107	910	6	2008	2008	CD
en-wikipedia-org-4107	910	7	)	)	-RRB-
en-wikipedia-org-4107	910	8	.	.	.
en-wikipedia-org-4107	911	1	"	"	``
en-wikipedia-org-4107	911	2	Pharmacology	pharmacology	NN
en-wikipedia-org-4107	911	3	of	of	IN
en-wikipedia-org-4107	911	4	stimulants	stimulant	NNS
en-wikipedia-org-4107	911	5	prohibited	prohibit	VBN
en-wikipedia-org-4107	911	6	by	by	IN
en-wikipedia-org-4107	911	7	the	the	DT
en-wikipedia-org-4107	911	8	World	World	NNP
en-wikipedia-org-4107	911	9	Anti	Anti	NNP
en-wikipedia-org-4107	911	10	-	-	NNP
en-wikipedia-org-4107	911	11	Doping	Doping	NNP
en-wikipedia-org-4107	911	12	Agency	Agency	NNP
en-wikipedia-org-4107	911	13	(	(	-LRB-
en-wikipedia-org-4107	911	14	WADA	WADA	NNP
en-wikipedia-org-4107	911	15	)	)	-RRB-
en-wikipedia-org-4107	911	16	"	"	''
en-wikipedia-org-4107	911	17	.	.	.
en-wikipedia-org-4107	912	1	British	British	NNP
en-wikipedia-org-4107	912	2	Journal	Journal	NNP
en-wikipedia-org-4107	912	3	of	of	IN
en-wikipedia-org-4107	912	4	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	912	5	.	.	.
en-wikipedia-org-4107	913	1	154	154	CD
en-wikipedia-org-4107	913	2	(	(	-LRB-
en-wikipedia-org-4107	913	3	3	3	CD
en-wikipedia-org-4107	913	4	)	)	-RRB-
en-wikipedia-org-4107	913	5	:	:	:
en-wikipedia-org-4107	913	6	606–622	606–622	CD
en-wikipedia-org-4107	913	7	.	.	.
en-wikipedia-org-4107	914	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-4107	914	2	/	/	SYM
en-wikipedia-org-4107	914	3	bjp.2008.124	bjp.2008.124	NNP
en-wikipedia-org-4107	914	4	.	.	.
en-wikipedia-org-4107	915	1	PMC	PMC	NNP
en-wikipedia-org-4107	915	2	 	  	_SP
en-wikipedia-org-4107	915	3	2439527	2439527	CD
en-wikipedia-org-4107	915	4	.	.	.
en-wikipedia-org-4107	916	1	PMID	PMID	NNP
en-wikipedia-org-4107	916	2	 	  	_SP
en-wikipedia-org-4107	916	3	18500382	18500382	CD
en-wikipedia-org-4107	916	4	.	.	.
en-wikipedia-org-4107	917	1	^	^	NNP
en-wikipedia-org-4107	917	2	a	a	DT
en-wikipedia-org-4107	917	3	b	b	NN
en-wikipedia-org-4107	917	4	c	c	NN
en-wikipedia-org-4107	917	5	d	d	NN
en-wikipedia-org-4107	917	6	Parr	Parr	NNP
en-wikipedia-org-4107	917	7	JW	JW	NNP
en-wikipedia-org-4107	917	8	(	(	-LRB-
en-wikipedia-org-4107	917	9	July	July	NNP
en-wikipedia-org-4107	917	10	2011	2011	CD
en-wikipedia-org-4107	917	11	)	)	-RRB-
en-wikipedia-org-4107	917	12	.	.	.
en-wikipedia-org-4107	918	1	"	"	``
en-wikipedia-org-4107	918	2	Attention	attention	NN
en-wikipedia-org-4107	918	3	-	-	HYPH
en-wikipedia-org-4107	918	4	deficit	deficit	NN
en-wikipedia-org-4107	918	5	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	918	6	disorder	disorder	NN
en-wikipedia-org-4107	918	7	and	and	CC
en-wikipedia-org-4107	918	8	the	the	DT
en-wikipedia-org-4107	918	9	athlete	athlete	NN
en-wikipedia-org-4107	918	10	:	:	:
en-wikipedia-org-4107	918	11	new	new	JJ
en-wikipedia-org-4107	918	12	advances	advance	NNS
en-wikipedia-org-4107	918	13	and	and	CC
en-wikipedia-org-4107	918	14	understanding	understanding	NN
en-wikipedia-org-4107	918	15	"	"	''
en-wikipedia-org-4107	918	16	.	.	.
en-wikipedia-org-4107	919	1	Clinics	Clinics	NNP
en-wikipedia-org-4107	919	2	in	in	IN
en-wikipedia-org-4107	919	3	Sports	Sports	NNP
en-wikipedia-org-4107	919	4	Medicine	Medicine	NNP
en-wikipedia-org-4107	919	5	.	.	.
en-wikipedia-org-4107	920	1	30	30	CD
en-wikipedia-org-4107	920	2	(	(	-LRB-
en-wikipedia-org-4107	920	3	3	3	CD
en-wikipedia-org-4107	920	4	)	)	-RRB-
en-wikipedia-org-4107	920	5	:	:	:
en-wikipedia-org-4107	920	6	591–610	591–610	CD
en-wikipedia-org-4107	920	7	.	.	.
en-wikipedia-org-4107	921	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	921	2	/	/	SYM
en-wikipedia-org-4107	921	3	j.csm.2011.03.007	j.csm.2011.03.007	NN
en-wikipedia-org-4107	921	4	.	.	.
en-wikipedia-org-4107	922	1	PMID	PMID	NNP
en-wikipedia-org-4107	922	2	 	  	_SP
en-wikipedia-org-4107	922	3	21658550	21658550	CD
en-wikipedia-org-4107	922	4	.	.	.
en-wikipedia-org-4107	923	1	In	in	IN
en-wikipedia-org-4107	923	2	1980	1980	CD
en-wikipedia-org-4107	923	3	,	,	,
en-wikipedia-org-4107	923	4	Chandler	Chandler	NNP
en-wikipedia-org-4107	923	5	and	and	CC
en-wikipedia-org-4107	923	6	Blair47	Blair47	NNP
en-wikipedia-org-4107	923	7	showed	show	VBD
en-wikipedia-org-4107	923	8	significant	significant	JJ
en-wikipedia-org-4107	923	9	increases	increase	NNS
en-wikipedia-org-4107	923	10	in	in	IN
en-wikipedia-org-4107	923	11	knee	knee	NN
en-wikipedia-org-4107	923	12	extension	extension	NN
en-wikipedia-org-4107	923	13	strength	strength	NN
en-wikipedia-org-4107	923	14	,	,	,
en-wikipedia-org-4107	923	15	acceleration	acceleration	NN
en-wikipedia-org-4107	923	16	,	,	,
en-wikipedia-org-4107	923	17	anaerobic	anaerobic	JJ
en-wikipedia-org-4107	923	18	capacity	capacity	NN
en-wikipedia-org-4107	923	19	,	,	,
en-wikipedia-org-4107	923	20	time	time	NN
en-wikipedia-org-4107	923	21	to	to	IN
en-wikipedia-org-4107	923	22	exhaustion	exhaustion	NN
en-wikipedia-org-4107	923	23	during	during	IN
en-wikipedia-org-4107	923	24	exercise	exercise	NN
en-wikipedia-org-4107	923	25	,	,	,
en-wikipedia-org-4107	923	26	pre	pre	JJ
en-wikipedia-org-4107	923	27	-	-	NN
en-wikipedia-org-4107	923	28	exercise	exercise	VB
en-wikipedia-org-4107	923	29	and	and	CC
en-wikipedia-org-4107	923	30	maximum	maximum	JJ
en-wikipedia-org-4107	923	31	heart	heart	NN
en-wikipedia-org-4107	923	32	rates	rate	NNS
en-wikipedia-org-4107	923	33	,	,	,
en-wikipedia-org-4107	923	34	and	and	CC
en-wikipedia-org-4107	923	35	time	time	NN
en-wikipedia-org-4107	923	36	to	to	IN
en-wikipedia-org-4107	923	37	exhaustion	exhaustion	NN
en-wikipedia-org-4107	923	38	during	during	IN
en-wikipedia-org-4107	923	39	maximal	maximal	JJ
en-wikipedia-org-4107	923	40	oxygen	oxygen	NN
en-wikipedia-org-4107	923	41	consumption	consumption	NN
en-wikipedia-org-4107	923	42	(	(	-LRB-
en-wikipedia-org-4107	923	43	VO2	VO2	NNP
en-wikipedia-org-4107	923	44	max	max	NNP
en-wikipedia-org-4107	923	45	)	)	-RRB-
en-wikipedia-org-4107	923	46	testing	test	VBG
en-wikipedia-org-4107	923	47	after	after	IN
en-wikipedia-org-4107	923	48	administration	administration	NN
en-wikipedia-org-4107	923	49	of	of	IN
en-wikipedia-org-4107	923	50	15	15	CD
en-wikipedia-org-4107	923	51	mg	mg	NNP
en-wikipedia-org-4107	923	52	of	of	IN
en-wikipedia-org-4107	923	53	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	923	54	versus	versus	IN
en-wikipedia-org-4107	923	55	placebo	placebo	NN
en-wikipedia-org-4107	923	56	.	.	.
en-wikipedia-org-4107	924	1	Most	Most	JJS
en-wikipedia-org-4107	924	2	of	of	IN
en-wikipedia-org-4107	924	3	the	the	DT
en-wikipedia-org-4107	924	4	information	information	NN
en-wikipedia-org-4107	924	5	to	to	TO
en-wikipedia-org-4107	924	6	answer	answer	VB
en-wikipedia-org-4107	924	7	this	this	DT
en-wikipedia-org-4107	924	8	question	question	NN
en-wikipedia-org-4107	924	9	has	have	VBZ
en-wikipedia-org-4107	924	10	been	be	VBN
en-wikipedia-org-4107	924	11	obtained	obtain	VBN
en-wikipedia-org-4107	924	12	in	in	IN
en-wikipedia-org-4107	924	13	the	the	DT
en-wikipedia-org-4107	924	14	past	past	JJ
en-wikipedia-org-4107	924	15	decade	decade	NN
en-wikipedia-org-4107	924	16	through	through	IN
en-wikipedia-org-4107	924	17	studies	study	NNS
en-wikipedia-org-4107	924	18	of	of	IN
en-wikipedia-org-4107	924	19	fatigue	fatigue	NN
en-wikipedia-org-4107	924	20	rather	rather	RB
en-wikipedia-org-4107	924	21	than	than	IN
en-wikipedia-org-4107	924	22	an	an	DT
en-wikipedia-org-4107	924	23	attempt	attempt	NN
en-wikipedia-org-4107	924	24	to	to	TO
en-wikipedia-org-4107	924	25	systematically	systematically	RB
en-wikipedia-org-4107	924	26	investigate	investigate	VB
en-wikipedia-org-4107	924	27	the	the	DT
en-wikipedia-org-4107	924	28	effect	effect	NN
en-wikipedia-org-4107	924	29	of	of	IN
en-wikipedia-org-4107	924	30	ADHD	ADHD	NNP
en-wikipedia-org-4107	924	31	drugs	drug	NNS
en-wikipedia-org-4107	924	32	on	on	IN
en-wikipedia-org-4107	924	33	exercise	exercise	NN
en-wikipedia-org-4107	924	34	.	.	.
en-wikipedia-org-4107	925	1	^	^	NNP
en-wikipedia-org-4107	925	2	a	a	DT
en-wikipedia-org-4107	925	3	b	b	NN
en-wikipedia-org-4107	925	4	c	c	NN
en-wikipedia-org-4107	925	5	Roelands	Roelands	NNP
en-wikipedia-org-4107	925	6	B	B	NNP
en-wikipedia-org-4107	925	7	,	,	,
en-wikipedia-org-4107	925	8	de	de	NNP
en-wikipedia-org-4107	925	9	Koning	Koning	NNP
en-wikipedia-org-4107	925	10	J	J	NNP
en-wikipedia-org-4107	925	11	,	,	,
en-wikipedia-org-4107	925	12	Foster	Foster	NNP
en-wikipedia-org-4107	925	13	C	C	NNP
en-wikipedia-org-4107	925	14	,	,	,
en-wikipedia-org-4107	925	15	Hettinga	Hettinga	NNP
en-wikipedia-org-4107	925	16	F	F	NNP
en-wikipedia-org-4107	925	17	,	,	,
en-wikipedia-org-4107	925	18	Meeusen	Meeusen	NNP
en-wikipedia-org-4107	925	19	R	R	NNP
en-wikipedia-org-4107	925	20	(	(	-LRB-
en-wikipedia-org-4107	925	21	May	May	NNP
en-wikipedia-org-4107	925	22	2013	2013	CD
en-wikipedia-org-4107	925	23	)	)	-RRB-
en-wikipedia-org-4107	925	24	.	.	.
en-wikipedia-org-4107	926	1	"	"	``
en-wikipedia-org-4107	926	2	Neurophysiological	neurophysiological	JJ
en-wikipedia-org-4107	926	3	determinants	determinant	NNS
en-wikipedia-org-4107	926	4	of	of	IN
en-wikipedia-org-4107	926	5	theoretical	theoretical	JJ
en-wikipedia-org-4107	926	6	concepts	concept	NNS
en-wikipedia-org-4107	926	7	and	and	CC
en-wikipedia-org-4107	926	8	mechanisms	mechanism	NNS
en-wikipedia-org-4107	926	9	involved	involve	VBN
en-wikipedia-org-4107	926	10	in	in	IN
en-wikipedia-org-4107	926	11	pacing	pace	VBG
en-wikipedia-org-4107	926	12	"	"	''
en-wikipedia-org-4107	926	13	.	.	.
en-wikipedia-org-4107	927	1	Sports	Sports	NNPS
en-wikipedia-org-4107	927	2	Medicine	Medicine	NNP
en-wikipedia-org-4107	927	3	.	.	.
en-wikipedia-org-4107	928	1	43	43	CD
en-wikipedia-org-4107	928	2	(	(	-LRB-
en-wikipedia-org-4107	928	3	5	5	CD
en-wikipedia-org-4107	928	4	)	)	-RRB-
en-wikipedia-org-4107	928	5	:	:	:
en-wikipedia-org-4107	928	6	301–311	301–311	CD
en-wikipedia-org-4107	928	7	.	.	.
en-wikipedia-org-4107	929	1	doi:10.1007	doi:10.1007	VB
en-wikipedia-org-4107	929	2	/	/	SYM
en-wikipedia-org-4107	929	3	s40279	s40279	NNP
en-wikipedia-org-4107	929	4	-	-	HYPH
en-wikipedia-org-4107	929	5	013	013	CD
en-wikipedia-org-4107	929	6	-	-	HYPH
en-wikipedia-org-4107	929	7	0030	0030	CD
en-wikipedia-org-4107	929	8	-	-	HYPH
en-wikipedia-org-4107	929	9	4	4	CD
en-wikipedia-org-4107	929	10	.	.	.
en-wikipedia-org-4107	930	1	PMID	PMID	NNP
en-wikipedia-org-4107	930	2	 	  	_SP
en-wikipedia-org-4107	930	3	23456493	23456493	CD
en-wikipedia-org-4107	930	4	.	.	.
en-wikipedia-org-4107	931	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	931	2	 	  	_SP
en-wikipedia-org-4107	931	3	30392999	30392999	CD
en-wikipedia-org-4107	931	4	.	.	.
en-wikipedia-org-4107	932	1	In	in	IN
en-wikipedia-org-4107	932	2	high	high	JJ
en-wikipedia-org-4107	932	3	-	-	HYPH
en-wikipedia-org-4107	932	4	ambient	ambient	NN
en-wikipedia-org-4107	932	5	temperatures	temperature	NNS
en-wikipedia-org-4107	932	6	,	,	,
en-wikipedia-org-4107	932	7	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	932	8	manipulations	manipulation	NNS
en-wikipedia-org-4107	932	9	clearly	clearly	RB
en-wikipedia-org-4107	932	10	improve	improve	VBP
en-wikipedia-org-4107	932	11	performance	performance	NN
en-wikipedia-org-4107	932	12	.	.	.
en-wikipedia-org-4107	933	1	The	the	DT
en-wikipedia-org-4107	933	2	distribution	distribution	NN
en-wikipedia-org-4107	933	3	of	of	IN
en-wikipedia-org-4107	933	4	the	the	DT
en-wikipedia-org-4107	933	5	power	power	NN
en-wikipedia-org-4107	933	6	output	output	NN
en-wikipedia-org-4107	933	7	reveals	reveal	VBZ
en-wikipedia-org-4107	933	8	that	that	IN
en-wikipedia-org-4107	933	9	after	after	IN
en-wikipedia-org-4107	933	10	dopamine	dopamine	NN
en-wikipedia-org-4107	933	11	reuptake	reuptake	NN
en-wikipedia-org-4107	933	12	inhibition	inhibition	NN
en-wikipedia-org-4107	933	13	,	,	,
en-wikipedia-org-4107	933	14	subjects	subject	NNS
en-wikipedia-org-4107	933	15	are	be	VBP
en-wikipedia-org-4107	933	16	able	able	JJ
en-wikipedia-org-4107	933	17	to	to	TO
en-wikipedia-org-4107	933	18	maintain	maintain	VB
en-wikipedia-org-4107	933	19	a	a	DT
en-wikipedia-org-4107	933	20	higher	high	JJR
en-wikipedia-org-4107	933	21	power	power	NN
en-wikipedia-org-4107	933	22	output	output	NN
en-wikipedia-org-4107	933	23	compared	compare	VBN
en-wikipedia-org-4107	933	24	with	with	IN
en-wikipedia-org-4107	933	25	placebo	placebo	NN
en-wikipedia-org-4107	933	26	.	.	.
en-wikipedia-org-4107	934	1	...	...	:
en-wikipedia-org-4107	934	2	Dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	934	3	drugs	drug	NNS
en-wikipedia-org-4107	934	4	appear	appear	VBP
en-wikipedia-org-4107	934	5	to	to	TO
en-wikipedia-org-4107	934	6	override	override	VB
en-wikipedia-org-4107	934	7	a	a	DT
en-wikipedia-org-4107	934	8	safety	safety	NN
en-wikipedia-org-4107	934	9	switch	switch	NN
en-wikipedia-org-4107	934	10	and	and	CC
en-wikipedia-org-4107	934	11	allow	allow	VB
en-wikipedia-org-4107	934	12	athletes	athlete	NNS
en-wikipedia-org-4107	934	13	to	to	TO
en-wikipedia-org-4107	934	14	use	use	VB
en-wikipedia-org-4107	934	15	a	a	DT
en-wikipedia-org-4107	934	16	reserve	reserve	NN
en-wikipedia-org-4107	934	17	capacity	capacity	NN
en-wikipedia-org-4107	934	18	that	that	WDT
en-wikipedia-org-4107	934	19	is	be	VBZ
en-wikipedia-org-4107	934	20	'	'	``
en-wikipedia-org-4107	934	21	off	off	IN
en-wikipedia-org-4107	934	22	-	-	HYPH
en-wikipedia-org-4107	934	23	limits	limit	NNS
en-wikipedia-org-4107	934	24	'	'	''
en-wikipedia-org-4107	934	25	in	in	IN
en-wikipedia-org-4107	934	26	a	a	DT
en-wikipedia-org-4107	934	27	normal	normal	JJ
en-wikipedia-org-4107	934	28	(	(	-LRB-
en-wikipedia-org-4107	934	29	placebo	placebo	NN
en-wikipedia-org-4107	934	30	)	)	-RRB-
en-wikipedia-org-4107	934	31	situation	situation	NN
en-wikipedia-org-4107	934	32	.	.	.
en-wikipedia-org-4107	935	1	^	^	NN
en-wikipedia-org-4107	935	2	Parker	Parker	NNP
en-wikipedia-org-4107	935	3	KL	KL	NNP
en-wikipedia-org-4107	935	4	,	,	,
en-wikipedia-org-4107	935	5	Lamichhane	Lamichhane	NNP
en-wikipedia-org-4107	935	6	D	D	NNP
en-wikipedia-org-4107	935	7	,	,	,
en-wikipedia-org-4107	935	8	Caetano	Caetano	NNP
en-wikipedia-org-4107	935	9	MS	MS	NNP
en-wikipedia-org-4107	935	10	,	,	,
en-wikipedia-org-4107	935	11	Narayanan	Narayanan	NNP
en-wikipedia-org-4107	935	12	NS	NS	NNP
en-wikipedia-org-4107	935	13	(	(	-LRB-
en-wikipedia-org-4107	935	14	October	October	NNP
en-wikipedia-org-4107	935	15	2013	2013	CD
en-wikipedia-org-4107	935	16	)	)	-RRB-
en-wikipedia-org-4107	935	17	.	.	.
en-wikipedia-org-4107	936	1	"	"	``
en-wikipedia-org-4107	936	2	Executive	executive	JJ
en-wikipedia-org-4107	936	3	dysfunction	dysfunction	NN
en-wikipedia-org-4107	936	4	in	in	IN
en-wikipedia-org-4107	936	5	Parkinson	Parkinson	NNP
en-wikipedia-org-4107	936	6	's	's	POS
en-wikipedia-org-4107	936	7	disease	disease	NN
en-wikipedia-org-4107	936	8	and	and	CC
en-wikipedia-org-4107	936	9	timing	timing	NN
en-wikipedia-org-4107	936	10	deficits	deficit	NNS
en-wikipedia-org-4107	936	11	"	"	''
en-wikipedia-org-4107	936	12	.	.	.
en-wikipedia-org-4107	937	1	Frontiers	frontier	NNS
en-wikipedia-org-4107	937	2	in	in	IN
en-wikipedia-org-4107	937	3	Integrative	Integrative	NNP
en-wikipedia-org-4107	937	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	937	5	.	.	.
en-wikipedia-org-4107	938	1	7	7	CD
en-wikipedia-org-4107	938	2	:	:	SYM
en-wikipedia-org-4107	938	3	75	75	CD
en-wikipedia-org-4107	938	4	.	.	.
en-wikipedia-org-4107	938	5	doi:10.3389	doi:10.3389	NNP
en-wikipedia-org-4107	938	6	/	/	SYM
en-wikipedia-org-4107	938	7	fnint.2013.00075	fnint.2013.00075	CD
en-wikipedia-org-4107	938	8	.	.	.
en-wikipedia-org-4107	939	1	PMC	PMC	NNP
en-wikipedia-org-4107	939	2	 	  	_SP
en-wikipedia-org-4107	939	3	3813949	3813949	CD
en-wikipedia-org-4107	939	4	.	.	.
en-wikipedia-org-4107	940	1	PMID	PMID	NNP
en-wikipedia-org-4107	940	2	 	  	_SP
en-wikipedia-org-4107	940	3	24198770	24198770	CD
en-wikipedia-org-4107	940	4	.	.	.
en-wikipedia-org-4107	941	1	Manipulations	manipulation	NNS
en-wikipedia-org-4107	941	2	of	of	IN
en-wikipedia-org-4107	941	3	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	941	4	signaling	signal	VBG
en-wikipedia-org-4107	941	5	profoundly	profoundly	RB
en-wikipedia-org-4107	941	6	influence	influence	NN
en-wikipedia-org-4107	941	7	interval	interval	JJ
en-wikipedia-org-4107	941	8	timing	timing	NN
en-wikipedia-org-4107	941	9	,	,	,
en-wikipedia-org-4107	941	10	leading	lead	VBG
en-wikipedia-org-4107	941	11	to	to	IN
en-wikipedia-org-4107	941	12	the	the	DT
en-wikipedia-org-4107	941	13	hypothesis	hypothesis	NN
en-wikipedia-org-4107	941	14	that	that	WDT
en-wikipedia-org-4107	941	15	dopamine	dopamine	NN
en-wikipedia-org-4107	941	16	influences	influence	VBZ
en-wikipedia-org-4107	941	17	internal	internal	JJ
en-wikipedia-org-4107	941	18	pacemaker	pacemaker	NN
en-wikipedia-org-4107	941	19	,	,	,
en-wikipedia-org-4107	941	20	or	or	CC
en-wikipedia-org-4107	941	21	"	"	``
en-wikipedia-org-4107	941	22	clock	clock	NN
en-wikipedia-org-4107	941	23	,	,	,
en-wikipedia-org-4107	941	24	"	"	''
en-wikipedia-org-4107	941	25	activity	activity	NN
en-wikipedia-org-4107	941	26	.	.	.
en-wikipedia-org-4107	942	1	For	for	IN
en-wikipedia-org-4107	942	2	instance	instance	NN
en-wikipedia-org-4107	942	3	,	,	,
en-wikipedia-org-4107	942	4	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	942	5	,	,	,
en-wikipedia-org-4107	942	6	which	which	WDT
en-wikipedia-org-4107	942	7	increases	increase	VBZ
en-wikipedia-org-4107	942	8	concentrations	concentration	NNS
en-wikipedia-org-4107	942	9	of	of	IN
en-wikipedia-org-4107	942	10	dopamine	dopamine	NN
en-wikipedia-org-4107	942	11	at	at	IN
en-wikipedia-org-4107	942	12	the	the	DT
en-wikipedia-org-4107	942	13	synaptic	synaptic	JJ
en-wikipedia-org-4107	942	14	cleft	cleft	NN
en-wikipedia-org-4107	942	15	advances	advance	VBZ
en-wikipedia-org-4107	942	16	the	the	DT
en-wikipedia-org-4107	942	17	start	start	NN
en-wikipedia-org-4107	942	18	of	of	IN
en-wikipedia-org-4107	942	19	responding	respond	VBG
en-wikipedia-org-4107	942	20	during	during	IN
en-wikipedia-org-4107	942	21	interval	interval	JJ
en-wikipedia-org-4107	942	22	timing	timing	NN
en-wikipedia-org-4107	942	23	,	,	,
en-wikipedia-org-4107	942	24	whereas	whereas	IN
en-wikipedia-org-4107	942	25	antagonists	antagonist	NNS
en-wikipedia-org-4107	942	26	of	of	IN
en-wikipedia-org-4107	942	27	D2	D2	NNP
en-wikipedia-org-4107	942	28	type	type	NN
en-wikipedia-org-4107	942	29	dopamine	dopamine	NN
en-wikipedia-org-4107	942	30	receptors	receptor	NNS
en-wikipedia-org-4107	942	31	typically	typically	RB
en-wikipedia-org-4107	942	32	slow	slow	JJ
en-wikipedia-org-4107	942	33	timing	timing	NN
en-wikipedia-org-4107	942	34	;	;	:
en-wikipedia-org-4107	942	35	...	...	:
en-wikipedia-org-4107	942	36	Depletion	depletion	NN
en-wikipedia-org-4107	942	37	of	of	IN
en-wikipedia-org-4107	942	38	dopamine	dopamine	NN
en-wikipedia-org-4107	942	39	in	in	IN
en-wikipedia-org-4107	942	40	healthy	healthy	JJ
en-wikipedia-org-4107	942	41	volunteers	volunteer	NNS
en-wikipedia-org-4107	942	42	impairs	impairs	VBP
en-wikipedia-org-4107	942	43	timing	timing	NN
en-wikipedia-org-4107	942	44	,	,	,
en-wikipedia-org-4107	942	45	while	while	IN
en-wikipedia-org-4107	942	46	amphetamine	amphetamine	NN
en-wikipedia-org-4107	942	47	releases	release	VBZ
en-wikipedia-org-4107	942	48	synaptic	synaptic	JJ
en-wikipedia-org-4107	942	49	dopamine	dopamine	NN
en-wikipedia-org-4107	942	50	and	and	CC
en-wikipedia-org-4107	942	51	speeds	speed	VBZ
en-wikipedia-org-4107	942	52	up	up	RP
en-wikipedia-org-4107	942	53	timing	timing	NN
en-wikipedia-org-4107	942	54	.	.	.
en-wikipedia-org-4107	943	1	^	^	NNP
en-wikipedia-org-4107	943	2	Rattray	Rattray	NNP
en-wikipedia-org-4107	943	3	B	B	NNP
en-wikipedia-org-4107	943	4	,	,	,
en-wikipedia-org-4107	943	5	Argus	Argus	NNP
en-wikipedia-org-4107	943	6	C	C	NNP
en-wikipedia-org-4107	943	7	,	,	,
en-wikipedia-org-4107	943	8	Martin	Martin	NNP
en-wikipedia-org-4107	943	9	K	K	NNP
en-wikipedia-org-4107	943	10	,	,	,
en-wikipedia-org-4107	943	11	Northey	Northey	NNP
en-wikipedia-org-4107	943	12	J	J	NNP
en-wikipedia-org-4107	943	13	,	,	,
en-wikipedia-org-4107	943	14	Driller	Driller	NNP
en-wikipedia-org-4107	943	15	M	M	NNP
en-wikipedia-org-4107	943	16	(	(	-LRB-
en-wikipedia-org-4107	943	17	March	March	NNP
en-wikipedia-org-4107	943	18	2015	2015	CD
en-wikipedia-org-4107	943	19	)	)	-RRB-
en-wikipedia-org-4107	943	20	.	.	.
en-wikipedia-org-4107	944	1	"	"	``
en-wikipedia-org-4107	944	2	Is	be	VBZ
en-wikipedia-org-4107	944	3	it	-PRON-	PRP
en-wikipedia-org-4107	944	4	time	time	NN
en-wikipedia-org-4107	944	5	to	to	TO
en-wikipedia-org-4107	944	6	turn	turn	VB
en-wikipedia-org-4107	944	7	our	-PRON-	PRP$
en-wikipedia-org-4107	944	8	attention	attention	NN
en-wikipedia-org-4107	944	9	toward	toward	IN
en-wikipedia-org-4107	944	10	central	central	JJ
en-wikipedia-org-4107	944	11	mechanisms	mechanism	NNS
en-wikipedia-org-4107	944	12	for	for	IN
en-wikipedia-org-4107	944	13	post	post	JJ
en-wikipedia-org-4107	944	14	-	-	JJ
en-wikipedia-org-4107	944	15	exertional	exertional	JJ
en-wikipedia-org-4107	944	16	recovery	recovery	NN
en-wikipedia-org-4107	944	17	strategies	strategy	NNS
en-wikipedia-org-4107	944	18	and	and	CC
en-wikipedia-org-4107	944	19	performance	performance	NN
en-wikipedia-org-4107	944	20	?	?	.
en-wikipedia-org-4107	944	21	"	"	''
en-wikipedia-org-4107	944	22	.	.	.
en-wikipedia-org-4107	945	1	Frontiers	Frontiers	NNP
en-wikipedia-org-4107	945	2	in	in	IN
en-wikipedia-org-4107	945	3	Physiology	Physiology	NNP
en-wikipedia-org-4107	945	4	.	.	.
en-wikipedia-org-4107	946	1	6	6	CD
en-wikipedia-org-4107	946	2	:	:	SYM
en-wikipedia-org-4107	946	3	79	79	CD
en-wikipedia-org-4107	946	4	.	.	.
en-wikipedia-org-4107	946	5	doi:10.3389	doi:10.3389	NNP
en-wikipedia-org-4107	946	6	/	/	SYM
en-wikipedia-org-4107	946	7	fphys.2015.00079	fphys.2015.00079	ADD
en-wikipedia-org-4107	946	8	.	.	.
en-wikipedia-org-4107	947	1	PMC	PMC	NNP
en-wikipedia-org-4107	947	2	 	  	_SP
en-wikipedia-org-4107	947	3	4362407	4362407	CD
en-wikipedia-org-4107	947	4	.	.	.
en-wikipedia-org-4107	948	1	PMID	PMID	NNP
en-wikipedia-org-4107	948	2	 	  	_SP
en-wikipedia-org-4107	948	3	25852568	25852568	CD
en-wikipedia-org-4107	948	4	.	.	.
en-wikipedia-org-4107	949	1	Aside	aside	RB
en-wikipedia-org-4107	949	2	from	from	IN
en-wikipedia-org-4107	949	3	accounting	account	VBG
en-wikipedia-org-4107	949	4	for	for	IN
en-wikipedia-org-4107	949	5	the	the	DT
en-wikipedia-org-4107	949	6	reduced	reduce	VBN
en-wikipedia-org-4107	949	7	performance	performance	NN
en-wikipedia-org-4107	949	8	of	of	IN
en-wikipedia-org-4107	949	9	mentally	mentally	RB
en-wikipedia-org-4107	949	10	fatigued	fatigue	VBN
en-wikipedia-org-4107	949	11	participants	participant	NNS
en-wikipedia-org-4107	949	12	,	,	,
en-wikipedia-org-4107	949	13	this	this	DT
en-wikipedia-org-4107	949	14	model	model	NN
en-wikipedia-org-4107	949	15	rationalizes	rationalize	VBZ
en-wikipedia-org-4107	949	16	the	the	DT
en-wikipedia-org-4107	949	17	reduced	reduced	JJ
en-wikipedia-org-4107	949	18	RPE	RPE	NNP
en-wikipedia-org-4107	949	19	and	and	CC
en-wikipedia-org-4107	949	20	hence	hence	RB
en-wikipedia-org-4107	949	21	improved	improve	VBD
en-wikipedia-org-4107	949	22	cycling	cycling	NN
en-wikipedia-org-4107	949	23	time	time	NN
en-wikipedia-org-4107	949	24	trial	trial	NN
en-wikipedia-org-4107	949	25	performance	performance	NN
en-wikipedia-org-4107	949	26	of	of	IN
en-wikipedia-org-4107	949	27	athletes	athlete	NNS
en-wikipedia-org-4107	949	28	using	use	VBG
en-wikipedia-org-4107	949	29	a	a	DT
en-wikipedia-org-4107	949	30	glucose	glucose	NN
en-wikipedia-org-4107	949	31	mouthwash	mouthwash	NN
en-wikipedia-org-4107	949	32	(	(	-LRB-
en-wikipedia-org-4107	949	33	Chambers	Chambers	NNPS
en-wikipedia-org-4107	949	34	et	et	NNP
en-wikipedia-org-4107	949	35	al	al	NNP
en-wikipedia-org-4107	949	36	.	.	NNP
en-wikipedia-org-4107	949	37	,	,	,
en-wikipedia-org-4107	949	38	2009	2009	CD
en-wikipedia-org-4107	949	39	)	)	-RRB-
en-wikipedia-org-4107	949	40	and	and	CC
en-wikipedia-org-4107	949	41	the	the	DT
en-wikipedia-org-4107	949	42	greater	great	JJR
en-wikipedia-org-4107	949	43	power	power	NN
en-wikipedia-org-4107	949	44	output	output	NN
en-wikipedia-org-4107	949	45	during	during	IN
en-wikipedia-org-4107	949	46	a	a	DT
en-wikipedia-org-4107	949	47	RPE	RPE	NNP
en-wikipedia-org-4107	949	48	matched	match	VBN
en-wikipedia-org-4107	949	49	cycling	cycling	NN
en-wikipedia-org-4107	949	50	time	time	NN
en-wikipedia-org-4107	949	51	trial	trial	NN
en-wikipedia-org-4107	949	52	following	follow	VBG
en-wikipedia-org-4107	949	53	amphetamine	amphetamine	NN
en-wikipedia-org-4107	949	54	ingestion	ingestion	NN
en-wikipedia-org-4107	949	55	(	(	-LRB-
en-wikipedia-org-4107	949	56	Swart	Swart	NNP
en-wikipedia-org-4107	949	57	,	,	,
en-wikipedia-org-4107	949	58	2009	2009	CD
en-wikipedia-org-4107	949	59	)	)	-RRB-
en-wikipedia-org-4107	949	60	.	.	.
en-wikipedia-org-4107	950	1	...	...	:
en-wikipedia-org-4107	950	2	Dopamine	dopamine	VB
en-wikipedia-org-4107	950	3	stimulating	stimulating	JJ
en-wikipedia-org-4107	950	4	drugs	drug	NNS
en-wikipedia-org-4107	950	5	are	be	VBP
en-wikipedia-org-4107	950	6	known	know	VBN
en-wikipedia-org-4107	950	7	to	to	TO
en-wikipedia-org-4107	950	8	enhance	enhance	VB
en-wikipedia-org-4107	950	9	aspects	aspect	NNS
en-wikipedia-org-4107	950	10	of	of	IN
en-wikipedia-org-4107	950	11	exercise	exercise	NN
en-wikipedia-org-4107	950	12	performance	performance	NN
en-wikipedia-org-4107	950	13	(	(	-LRB-
en-wikipedia-org-4107	950	14	Roelands	Roelands	NNP
en-wikipedia-org-4107	950	15	et	et	NNP
en-wikipedia-org-4107	950	16	al	al	NNP
en-wikipedia-org-4107	950	17	.	.	NNP
en-wikipedia-org-4107	950	18	,	,	,
en-wikipedia-org-4107	950	19	2008	2008	CD
en-wikipedia-org-4107	950	20	)	)	-RRB-
en-wikipedia-org-4107	950	21	^	^	NN
en-wikipedia-org-4107	950	22	Roelands	Roelands	NNP
en-wikipedia-org-4107	950	23	B	B	NNP
en-wikipedia-org-4107	950	24	,	,	,
en-wikipedia-org-4107	950	25	De	De	NNP
en-wikipedia-org-4107	950	26	Pauw	Pauw	NNP
en-wikipedia-org-4107	950	27	K	K	NNP
en-wikipedia-org-4107	950	28	,	,	,
en-wikipedia-org-4107	950	29	Meeusen	Meeusen	NNP
en-wikipedia-org-4107	950	30	R	R	NNP
en-wikipedia-org-4107	950	31	(	(	-LRB-
en-wikipedia-org-4107	950	32	June	June	NNP
en-wikipedia-org-4107	950	33	2015	2015	CD
en-wikipedia-org-4107	950	34	)	)	-RRB-
en-wikipedia-org-4107	950	35	.	.	.
en-wikipedia-org-4107	951	1	"	"	``
en-wikipedia-org-4107	951	2	Neurophysiological	neurophysiological	JJ
en-wikipedia-org-4107	951	3	effects	effect	NNS
en-wikipedia-org-4107	951	4	of	of	IN
en-wikipedia-org-4107	951	5	exercise	exercise	NN
en-wikipedia-org-4107	951	6	in	in	IN
en-wikipedia-org-4107	951	7	the	the	DT
en-wikipedia-org-4107	951	8	heat	heat	NN
en-wikipedia-org-4107	951	9	"	"	''
en-wikipedia-org-4107	951	10	.	.	.
en-wikipedia-org-4107	952	1	Scandinavian	Scandinavian	NNP
en-wikipedia-org-4107	952	2	Journal	Journal	NNP
en-wikipedia-org-4107	952	3	of	of	IN
en-wikipedia-org-4107	952	4	Medicine	Medicine	NNP
en-wikipedia-org-4107	952	5	&	&	CC
en-wikipedia-org-4107	952	6	Science	Science	NNP
en-wikipedia-org-4107	952	7	in	in	IN
en-wikipedia-org-4107	952	8	Sports	Sports	NNP
en-wikipedia-org-4107	952	9	.	.	.
en-wikipedia-org-4107	953	1	25	25	CD
en-wikipedia-org-4107	953	2	(	(	-LRB-
en-wikipedia-org-4107	953	3	Suppl	Suppl	NNP
en-wikipedia-org-4107	953	4	1	1	CD
en-wikipedia-org-4107	953	5	)	)	-RRB-
en-wikipedia-org-4107	953	6	:	:	:
en-wikipedia-org-4107	953	7	65–78	65–78	CD
en-wikipedia-org-4107	953	8	.	.	.
en-wikipedia-org-4107	954	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-4107	954	2	/	/	SYM
en-wikipedia-org-4107	954	3	sms.12350	sms.12350	NN
en-wikipedia-org-4107	954	4	.	.	.
en-wikipedia-org-4107	955	1	PMID	PMID	NNP
en-wikipedia-org-4107	955	2	 	  	_SP
en-wikipedia-org-4107	955	3	25943657	25943657	CD
en-wikipedia-org-4107	955	4	.	.	.
en-wikipedia-org-4107	956	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	956	2	 	  	_SP
en-wikipedia-org-4107	956	3	22782401	22782401	CD
en-wikipedia-org-4107	956	4	.	.	.
en-wikipedia-org-4107	957	1	This	this	DT
en-wikipedia-org-4107	957	2	indicates	indicate	VBZ
en-wikipedia-org-4107	957	3	that	that	IN
en-wikipedia-org-4107	957	4	subjects	subject	NNS
en-wikipedia-org-4107	957	5	did	do	VBD
en-wikipedia-org-4107	957	6	not	not	RB
en-wikipedia-org-4107	957	7	feel	feel	VB
en-wikipedia-org-4107	957	8	they	-PRON-	PRP
en-wikipedia-org-4107	957	9	were	be	VBD
en-wikipedia-org-4107	957	10	producing	produce	VBG
en-wikipedia-org-4107	957	11	more	more	JJR
en-wikipedia-org-4107	957	12	power	power	NN
en-wikipedia-org-4107	957	13	and	and	CC
en-wikipedia-org-4107	957	14	consequently	consequently	RB
en-wikipedia-org-4107	957	15	more	more	JJR
en-wikipedia-org-4107	957	16	heat	heat	NN
en-wikipedia-org-4107	957	17	.	.	.
en-wikipedia-org-4107	958	1	The	the	DT
en-wikipedia-org-4107	958	2	authors	author	NNS
en-wikipedia-org-4107	958	3	concluded	conclude	VBD
en-wikipedia-org-4107	958	4	that	that	IN
en-wikipedia-org-4107	958	5	the	the	DT
en-wikipedia-org-4107	958	6	"	"	``
en-wikipedia-org-4107	958	7	safety	safety	NN
en-wikipedia-org-4107	958	8	switch	switch	NN
en-wikipedia-org-4107	958	9	"	"	''
en-wikipedia-org-4107	958	10	or	or	CC
en-wikipedia-org-4107	958	11	the	the	DT
en-wikipedia-org-4107	958	12	mechanisms	mechanism	NNS
en-wikipedia-org-4107	958	13	existing	exist	VBG
en-wikipedia-org-4107	958	14	in	in	IN
en-wikipedia-org-4107	958	15	the	the	DT
en-wikipedia-org-4107	958	16	body	body	NN
en-wikipedia-org-4107	958	17	to	to	TO
en-wikipedia-org-4107	958	18	prevent	prevent	VB
en-wikipedia-org-4107	958	19	harmful	harmful	JJ
en-wikipedia-org-4107	958	20	effects	effect	NNS
en-wikipedia-org-4107	958	21	are	be	VBP
en-wikipedia-org-4107	958	22	overridden	override	VBN
en-wikipedia-org-4107	958	23	by	by	IN
en-wikipedia-org-4107	958	24	the	the	DT
en-wikipedia-org-4107	958	25	drug	drug	NN
en-wikipedia-org-4107	958	26	administration	administration	NN
en-wikipedia-org-4107	958	27	(	(	-LRB-
en-wikipedia-org-4107	958	28	Roelands	Roelands	NNP
en-wikipedia-org-4107	958	29	et	et	NNP
en-wikipedia-org-4107	958	30	al	al	NNP
en-wikipedia-org-4107	958	31	.	.	NNP
en-wikipedia-org-4107	958	32	,	,	,
en-wikipedia-org-4107	958	33	2008b	2008b	CD
en-wikipedia-org-4107	958	34	)	)	-RRB-
en-wikipedia-org-4107	958	35	.	.	.
en-wikipedia-org-4107	959	1	Taken	take	VBN
en-wikipedia-org-4107	959	2	together	together	RB
en-wikipedia-org-4107	959	3	,	,	,
en-wikipedia-org-4107	959	4	these	these	DT
en-wikipedia-org-4107	959	5	data	datum	NNS
en-wikipedia-org-4107	959	6	indicate	indicate	VBP
en-wikipedia-org-4107	959	7	strong	strong	JJ
en-wikipedia-org-4107	959	8	ergogenic	ergogenic	JJ
en-wikipedia-org-4107	959	9	effects	effect	NNS
en-wikipedia-org-4107	959	10	of	of	IN
en-wikipedia-org-4107	959	11	an	an	DT
en-wikipedia-org-4107	959	12	increased	increase	VBN
en-wikipedia-org-4107	959	13	DA	DA	NNP
en-wikipedia-org-4107	959	14	concentration	concentration	NN
en-wikipedia-org-4107	959	15	in	in	IN
en-wikipedia-org-4107	959	16	the	the	DT
en-wikipedia-org-4107	959	17	brain	brain	NN
en-wikipedia-org-4107	959	18	,	,	,
en-wikipedia-org-4107	959	19	without	without	IN
en-wikipedia-org-4107	959	20	any	any	DT
en-wikipedia-org-4107	959	21	change	change	NN
en-wikipedia-org-4107	959	22	in	in	IN
en-wikipedia-org-4107	959	23	the	the	DT
en-wikipedia-org-4107	959	24	perception	perception	NN
en-wikipedia-org-4107	959	25	of	of	IN
en-wikipedia-org-4107	959	26	effort	effort	NN
en-wikipedia-org-4107	959	27	.	.	.
en-wikipedia-org-4107	960	1	^	^	NFP
en-wikipedia-org-4107	960	2	Kessler	Kessler	NNP
en-wikipedia-org-4107	960	3	S	S	NNP
en-wikipedia-org-4107	960	4	(	(	-LRB-
en-wikipedia-org-4107	960	5	January	January	NNP
en-wikipedia-org-4107	960	6	1996	1996	CD
en-wikipedia-org-4107	960	7	)	)	-RRB-
en-wikipedia-org-4107	960	8	.	.	.
en-wikipedia-org-4107	961	1	"	"	``
en-wikipedia-org-4107	961	2	Drug	drug	NN
en-wikipedia-org-4107	961	3	therapy	therapy	NN
en-wikipedia-org-4107	961	4	in	in	IN
en-wikipedia-org-4107	961	5	attention	attention	NN
en-wikipedia-org-4107	961	6	-	-	HYPH
en-wikipedia-org-4107	961	7	deficit	deficit	NN
en-wikipedia-org-4107	961	8	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	961	9	disorder	disorder	NN
en-wikipedia-org-4107	961	10	"	"	''
en-wikipedia-org-4107	961	11	.	.	.
en-wikipedia-org-4107	962	1	Southern	Southern	NNP
en-wikipedia-org-4107	962	2	Medical	Medical	NNP
en-wikipedia-org-4107	962	3	Journal	Journal	NNP
en-wikipedia-org-4107	962	4	.	.	.
en-wikipedia-org-4107	963	1	89	89	CD
en-wikipedia-org-4107	963	2	(	(	-LRB-
en-wikipedia-org-4107	963	3	1	1	CD
en-wikipedia-org-4107	963	4	)	)	-RRB-
en-wikipedia-org-4107	963	5	:	:	:
en-wikipedia-org-4107	963	6	33–38	33–38	CD
en-wikipedia-org-4107	963	7	.	.	.
en-wikipedia-org-4107	964	1	doi:10.1097/00007611	doi:10.1097/00007611	JJ
en-wikipedia-org-4107	964	2	-	-	HYPH
en-wikipedia-org-4107	964	3	199601000	199601000	CD
en-wikipedia-org-4107	964	4	-	-	HYPH
en-wikipedia-org-4107	964	5	00005	00005	CD
en-wikipedia-org-4107	964	6	.	.	.
en-wikipedia-org-4107	965	1	PMID	PMID	NNP
en-wikipedia-org-4107	965	2	 	  	_SP
en-wikipedia-org-4107	965	3	8545689	8545689	CD
en-wikipedia-org-4107	965	4	.	.	.
en-wikipedia-org-4107	966	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	966	2	 	  	_SP
en-wikipedia-org-4107	966	3	12798818	12798818	CD
en-wikipedia-org-4107	966	4	.	.	.
en-wikipedia-org-4107	966	5	statements	statement	NNS
en-wikipedia-org-4107	966	6	on	on	IN
en-wikipedia-org-4107	966	7	package	package	NN
en-wikipedia-org-4107	966	8	inserts	insert	NNS
en-wikipedia-org-4107	966	9	are	be	VBP
en-wikipedia-org-4107	966	10	not	not	RB
en-wikipedia-org-4107	966	11	intended	intend	VBN
en-wikipedia-org-4107	966	12	to	to	TO
en-wikipedia-org-4107	966	13	limit	limit	VB
en-wikipedia-org-4107	966	14	medical	medical	JJ
en-wikipedia-org-4107	966	15	practice	practice	NN
en-wikipedia-org-4107	966	16	.	.	.
en-wikipedia-org-4107	967	1	Rather	rather	RB
en-wikipedia-org-4107	967	2	they	-PRON-	PRP
en-wikipedia-org-4107	967	3	are	be	VBP
en-wikipedia-org-4107	967	4	intended	intend	VBN
en-wikipedia-org-4107	967	5	to	to	TO
en-wikipedia-org-4107	967	6	limit	limit	VB
en-wikipedia-org-4107	967	7	claims	claim	NNS
en-wikipedia-org-4107	967	8	by	by	IN
en-wikipedia-org-4107	967	9	pharmaceutical	pharmaceutical	NN
en-wikipedia-org-4107	967	10	companies	company	NNS
en-wikipedia-org-4107	967	11	.	.	.
en-wikipedia-org-4107	968	1	...	...	:
en-wikipedia-org-4107	968	2	the	the	DT
en-wikipedia-org-4107	968	3	FDA	FDA	NNP
en-wikipedia-org-4107	968	4	asserts	assert	VBZ
en-wikipedia-org-4107	968	5	explicitly	explicitly	RB
en-wikipedia-org-4107	968	6	,	,	,
en-wikipedia-org-4107	968	7	and	and	CC
en-wikipedia-org-4107	968	8	the	the	DT
en-wikipedia-org-4107	968	9	courts	court	NNS
en-wikipedia-org-4107	968	10	have	have	VBP
en-wikipedia-org-4107	968	11	upheld	uphold	VBN
en-wikipedia-org-4107	968	12	that	that	IN
en-wikipedia-org-4107	968	13	clinical	clinical	JJ
en-wikipedia-org-4107	968	14	decisions	decision	NNS
en-wikipedia-org-4107	968	15	are	be	VBP
en-wikipedia-org-4107	968	16	to	to	TO
en-wikipedia-org-4107	968	17	be	be	VB
en-wikipedia-org-4107	968	18	made	make	VBN
en-wikipedia-org-4107	968	19	by	by	IN
en-wikipedia-org-4107	968	20	physicians	physician	NNS
en-wikipedia-org-4107	968	21	and	and	CC
en-wikipedia-org-4107	968	22	patients	patient	NNS
en-wikipedia-org-4107	968	23	in	in	IN
en-wikipedia-org-4107	968	24	individual	individual	JJ
en-wikipedia-org-4107	968	25	situations	situation	NNS
en-wikipedia-org-4107	968	26	.	.	.
en-wikipedia-org-4107	969	1	^	^	NNP
en-wikipedia-org-4107	969	2	a	a	DT
en-wikipedia-org-4107	969	3	b	b	NNP
en-wikipedia-org-4107	969	4	c	c	NNP
en-wikipedia-org-4107	969	5	d	d	NNP
en-wikipedia-org-4107	969	6	e	e	NNP
en-wikipedia-org-4107	969	7	f	f	NNP
en-wikipedia-org-4107	969	8	g	g	NNP
en-wikipedia-org-4107	969	9	h	h	NNP
en-wikipedia-org-4107	969	10	i	i	NN
en-wikipedia-org-4107	969	11	j	j	NNP
en-wikipedia-org-4107	969	12	k	k	NNP
en-wikipedia-org-4107	969	13	Heedes	Heedes	NNP
en-wikipedia-org-4107	969	14	G	G	NNP
en-wikipedia-org-4107	969	15	,	,	,
en-wikipedia-org-4107	969	16	Ailakis	Ailakis	NNP
en-wikipedia-org-4107	969	17	J.	J.	NNP
en-wikipedia-org-4107	970	1	"	"	``
en-wikipedia-org-4107	970	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	970	3	(	(	-LRB-
en-wikipedia-org-4107	970	4	PIM	PIM	NNP
en-wikipedia-org-4107	970	5	934	934	CD
en-wikipedia-org-4107	970	6	)	)	-RRB-
en-wikipedia-org-4107	970	7	"	"	''
en-wikipedia-org-4107	970	8	.	.	.
en-wikipedia-org-4107	971	1	INCHEM	INCHEM	NNP
en-wikipedia-org-4107	971	2	.	.	.
en-wikipedia-org-4107	972	1	International	International	NNP
en-wikipedia-org-4107	972	2	Programme	Programme	NNP
en-wikipedia-org-4107	972	3	on	on	IN
en-wikipedia-org-4107	972	4	Chemical	Chemical	NNP
en-wikipedia-org-4107	972	5	Safety	Safety	NNP
en-wikipedia-org-4107	972	6	.	.	.
en-wikipedia-org-4107	973	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	973	2	24	24	CD
en-wikipedia-org-4107	973	3	June	June	NNP
en-wikipedia-org-4107	973	4	2014	2014	CD
en-wikipedia-org-4107	973	5	.	.	.
en-wikipedia-org-4107	974	1	^	^	NNP
en-wikipedia-org-4107	974	2	Feinberg	Feinberg	NNP
en-wikipedia-org-4107	974	3	SS	SS	NNP
en-wikipedia-org-4107	974	4	(	(	-LRB-
en-wikipedia-org-4107	974	5	November	November	NNP
en-wikipedia-org-4107	974	6	2004	2004	CD
en-wikipedia-org-4107	974	7	)	)	-RRB-
en-wikipedia-org-4107	974	8	.	.	.
en-wikipedia-org-4107	975	1	"	"	``
en-wikipedia-org-4107	975	2	Combining	combine	VBG
en-wikipedia-org-4107	975	3	stimulants	stimulant	NNS
en-wikipedia-org-4107	975	4	with	with	IN
en-wikipedia-org-4107	975	5	monoamine	monoamine	NN
en-wikipedia-org-4107	975	6	oxidase	oxidase	NNP
en-wikipedia-org-4107	975	7	inhibitors	inhibitor	NNS
en-wikipedia-org-4107	975	8	:	:	:
en-wikipedia-org-4107	975	9	a	a	DT
en-wikipedia-org-4107	975	10	review	review	NN
en-wikipedia-org-4107	975	11	of	of	IN
en-wikipedia-org-4107	975	12	uses	use	NNS
en-wikipedia-org-4107	975	13	and	and	CC
en-wikipedia-org-4107	975	14	one	one	CD
en-wikipedia-org-4107	975	15	possible	possible	JJ
en-wikipedia-org-4107	975	16	additional	additional	JJ
en-wikipedia-org-4107	975	17	indication	indication	NN
en-wikipedia-org-4107	975	18	"	"	''
en-wikipedia-org-4107	975	19	.	.	.
en-wikipedia-org-4107	976	1	The	the	DT
en-wikipedia-org-4107	976	2	Journal	Journal	NNP
en-wikipedia-org-4107	976	3	of	of	IN
en-wikipedia-org-4107	976	4	Clinical	Clinical	NNP
en-wikipedia-org-4107	976	5	Psychiatry	Psychiatry	NNP
en-wikipedia-org-4107	976	6	.	.	.
en-wikipedia-org-4107	977	1	65	65	CD
en-wikipedia-org-4107	977	2	(	(	-LRB-
en-wikipedia-org-4107	977	3	11	11	CD
en-wikipedia-org-4107	977	4	)	)	-RRB-
en-wikipedia-org-4107	977	5	:	:	:
en-wikipedia-org-4107	977	6	1520–1524	1520–1524	CD
en-wikipedia-org-4107	977	7	.	.	.
en-wikipedia-org-4107	978	1	doi:10.4088	doi:10.4088	NNP
en-wikipedia-org-4107	978	2	/	/	SYM
en-wikipedia-org-4107	978	3	jcp.v65n1113	jcp.v65n1113	NNP
en-wikipedia-org-4107	978	4	.	.	.
en-wikipedia-org-4107	979	1	PMID	PMID	NNP
en-wikipedia-org-4107	979	2	 	  	_SP
en-wikipedia-org-4107	979	3	15554766	15554766	CD
en-wikipedia-org-4107	979	4	.	.	.
en-wikipedia-org-4107	980	1	^	^	NNP
en-wikipedia-org-4107	980	2	Stewart	Stewart	NNP
en-wikipedia-org-4107	980	3	JW	JW	NNP
en-wikipedia-org-4107	980	4	,	,	,
en-wikipedia-org-4107	980	5	Deliyannides	Deliyannides	NNP
en-wikipedia-org-4107	980	6	DA	DA	NNP
en-wikipedia-org-4107	980	7	,	,	,
en-wikipedia-org-4107	980	8	McGrath	McGrath	NNP
en-wikipedia-org-4107	980	9	PJ	PJ	NNP
en-wikipedia-org-4107	980	10	(	(	-LRB-
en-wikipedia-org-4107	980	11	June	June	NNP
en-wikipedia-org-4107	980	12	2014	2014	CD
en-wikipedia-org-4107	980	13	)	)	-RRB-
en-wikipedia-org-4107	980	14	.	.	.
en-wikipedia-org-4107	981	1	"	"	``
en-wikipedia-org-4107	981	2	How	how	WRB
en-wikipedia-org-4107	981	3	treatable	treatable	JJ
en-wikipedia-org-4107	981	4	is	be	VBZ
en-wikipedia-org-4107	981	5	refractory	refractory	JJ
en-wikipedia-org-4107	981	6	depression	depression	NN
en-wikipedia-org-4107	981	7	?	?	.
en-wikipedia-org-4107	981	8	"	"	''
en-wikipedia-org-4107	981	9	.	.	.
en-wikipedia-org-4107	982	1	Journal	Journal	NNP
en-wikipedia-org-4107	982	2	of	of	IN
en-wikipedia-org-4107	982	3	Affective	Affective	NNP
en-wikipedia-org-4107	982	4	Disorders	Disorders	NNPS
en-wikipedia-org-4107	982	5	.	.	.
en-wikipedia-org-4107	983	1	167	167	CD
en-wikipedia-org-4107	983	2	:	:	:
en-wikipedia-org-4107	983	3	148–152	148–152	CD
en-wikipedia-org-4107	983	4	.	.	.
en-wikipedia-org-4107	984	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	984	2	/	/	SYM
en-wikipedia-org-4107	984	3	j.jad.2014.05.047	j.jad.2014.05.047	NNS
en-wikipedia-org-4107	984	4	.	.	.
en-wikipedia-org-4107	985	1	PMID	PMID	NNP
en-wikipedia-org-4107	985	2	 	  	_SP
en-wikipedia-org-4107	985	3	24972362	24972362	CD
en-wikipedia-org-4107	985	4	.	.	.
en-wikipedia-org-4107	986	1	^	^	NNP
en-wikipedia-org-4107	986	2	a	a	DT
en-wikipedia-org-4107	986	3	b	b	NN
en-wikipedia-org-4107	986	4	c	c	NN
en-wikipedia-org-4107	986	5	d	d	NN
en-wikipedia-org-4107	986	6	Vitiello	Vitiello	NNP
en-wikipedia-org-4107	986	7	B	B	NNP
en-wikipedia-org-4107	986	8	(	(	-LRB-
en-wikipedia-org-4107	986	9	April	April	NNP
en-wikipedia-org-4107	986	10	2008	2008	CD
en-wikipedia-org-4107	986	11	)	)	-RRB-
en-wikipedia-org-4107	986	12	.	.	.
en-wikipedia-org-4107	987	1	"	"	``
en-wikipedia-org-4107	987	2	Understanding	understand	VBG
en-wikipedia-org-4107	987	3	the	the	DT
en-wikipedia-org-4107	987	4	risk	risk	NN
en-wikipedia-org-4107	987	5	of	of	IN
en-wikipedia-org-4107	987	6	using	use	VBG
en-wikipedia-org-4107	987	7	medications	medication	NNS
en-wikipedia-org-4107	987	8	for	for	IN
en-wikipedia-org-4107	987	9	attention	attention	NN
en-wikipedia-org-4107	987	10	deficit	deficit	NN
en-wikipedia-org-4107	987	11	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	987	12	disorder	disorder	NN
en-wikipedia-org-4107	987	13	with	with	IN
en-wikipedia-org-4107	987	14	respect	respect	NN
en-wikipedia-org-4107	987	15	to	to	IN
en-wikipedia-org-4107	987	16	physical	physical	JJ
en-wikipedia-org-4107	987	17	growth	growth	NN
en-wikipedia-org-4107	987	18	and	and	CC
en-wikipedia-org-4107	987	19	cardiovascular	cardiovascular	JJ
en-wikipedia-org-4107	987	20	function	function	NN
en-wikipedia-org-4107	987	21	"	"	''
en-wikipedia-org-4107	987	22	.	.	.
en-wikipedia-org-4107	988	1	Child	child	NN
en-wikipedia-org-4107	988	2	and	and	CC
en-wikipedia-org-4107	988	3	Adolescent	Adolescent	NNP
en-wikipedia-org-4107	988	4	Psychiatric	Psychiatric	NNP
en-wikipedia-org-4107	988	5	Clinics	Clinics	NNPS
en-wikipedia-org-4107	988	6	of	of	IN
en-wikipedia-org-4107	988	7	North	North	NNP
en-wikipedia-org-4107	988	8	America	America	NNP
en-wikipedia-org-4107	988	9	.	.	.
en-wikipedia-org-4107	989	1	17	17	CD
en-wikipedia-org-4107	989	2	(	(	-LRB-
en-wikipedia-org-4107	989	3	2	2	CD
en-wikipedia-org-4107	989	4	)	)	-RRB-
en-wikipedia-org-4107	989	5	:	:	:
en-wikipedia-org-4107	989	6	459–474	459–474	CD
en-wikipedia-org-4107	989	7	.	.	.
en-wikipedia-org-4107	990	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	990	2	/	/	SYM
en-wikipedia-org-4107	990	3	j.chc.2007.11.010	j.chc.2007.11.010	NNP
en-wikipedia-org-4107	990	4	.	.	.
en-wikipedia-org-4107	991	1	PMC	PMC	NNP
en-wikipedia-org-4107	991	2	 	  	_SP
en-wikipedia-org-4107	991	3	2408826	2408826	CD
en-wikipedia-org-4107	991	4	.	.	.
en-wikipedia-org-4107	992	1	PMID	PMID	NNP
en-wikipedia-org-4107	992	2	 	  	_SP
en-wikipedia-org-4107	992	3	18295156	18295156	CD
en-wikipedia-org-4107	992	4	.	.	.
en-wikipedia-org-4107	993	1	^	^	NNP
en-wikipedia-org-4107	993	2	a	a	DT
en-wikipedia-org-4107	993	3	b	b	NNP
en-wikipedia-org-4107	993	4	c	c	NNP
en-wikipedia-org-4107	993	5	d	d	NNP
en-wikipedia-org-4107	993	6	e	e	NNP
en-wikipedia-org-4107	993	7	f	f	NNP
en-wikipedia-org-4107	993	8	g	g	NN
en-wikipedia-org-4107	993	9	h	h	NN
en-wikipedia-org-4107	993	10	"	"	``
en-wikipedia-org-4107	993	11	Dyanavel	Dyanavel	NNP
en-wikipedia-org-4107	993	12	XR-	XR-	NNP
en-wikipedia-org-4107	993	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	993	14	suspension	suspension	NN
en-wikipedia-org-4107	993	15	,	,	,
en-wikipedia-org-4107	993	16	extended	extended	JJ
en-wikipedia-org-4107	993	17	release	release	NN
en-wikipedia-org-4107	993	18	"	"	''
en-wikipedia-org-4107	993	19	.	.	.
en-wikipedia-org-4107	994	1	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	994	2	.	.	.
en-wikipedia-org-4107	995	1	Tris	Tris	NNP
en-wikipedia-org-4107	995	2	Pharma	Pharma	NNP
en-wikipedia-org-4107	995	3	,	,	,
en-wikipedia-org-4107	995	4	Inc.	Inc.	NNP
en-wikipedia-org-4107	995	5	6	6	CD
en-wikipedia-org-4107	995	6	February	February	NNP
en-wikipedia-org-4107	995	7	2019	2019	CD
en-wikipedia-org-4107	995	8	.	.	.
en-wikipedia-org-4107	996	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	996	2	22	22	CD
en-wikipedia-org-4107	996	3	December	December	NNP
en-wikipedia-org-4107	996	4	2019	2019	CD
en-wikipedia-org-4107	996	5	.	.	.
en-wikipedia-org-4107	997	1	DYANAVEL	DYANAVEL	NNP
en-wikipedia-org-4107	997	2	XR	XR	NNP
en-wikipedia-org-4107	997	3	contains	contain	VBZ
en-wikipedia-org-4107	997	4	d	d	NNP
en-wikipedia-org-4107	997	5	-	-	HYPH
en-wikipedia-org-4107	997	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	997	7	and	and	CC
en-wikipedia-org-4107	997	8	l	l	NNP
en-wikipedia-org-4107	997	9	-	-	HYPH
en-wikipedia-org-4107	997	10	amphetamine	amphetamine	NN
en-wikipedia-org-4107	997	11	in	in	IN
en-wikipedia-org-4107	997	12	a	a	DT
en-wikipedia-org-4107	997	13	ratio	ratio	NN
en-wikipedia-org-4107	997	14	of	of	IN
en-wikipedia-org-4107	997	15	3.2	3.2	CD
en-wikipedia-org-4107	997	16	to	to	TO
en-wikipedia-org-4107	997	17	1	1	CD
en-wikipedia-org-4107	997	18	 	  	_SP
en-wikipedia-org-4107	997	19	...	...	.
en-wikipedia-org-4107	998	1	The	the	DT
en-wikipedia-org-4107	998	2	most	most	RBS
en-wikipedia-org-4107	998	3	common	common	JJ
en-wikipedia-org-4107	998	4	(	(	-LRB-
en-wikipedia-org-4107	998	5	≥2	≥2	NNP
en-wikipedia-org-4107	998	6	%	%	NN
en-wikipedia-org-4107	998	7	in	in	IN
en-wikipedia-org-4107	998	8	the	the	DT
en-wikipedia-org-4107	998	9	DYANAVEL	DYANAVEL	NNP
en-wikipedia-org-4107	998	10	XR	XR	NNP
en-wikipedia-org-4107	998	11	group	group	NN
en-wikipedia-org-4107	998	12	and	and	CC
en-wikipedia-org-4107	998	13	greater	great	JJR
en-wikipedia-org-4107	998	14	than	than	IN
en-wikipedia-org-4107	998	15	placebo	placebo	NN
en-wikipedia-org-4107	998	16	)	)	-RRB-
en-wikipedia-org-4107	998	17	adverse	adverse	JJ
en-wikipedia-org-4107	998	18	reactions	reaction	NNS
en-wikipedia-org-4107	998	19	reported	report	VBN
en-wikipedia-org-4107	998	20	in	in	IN
en-wikipedia-org-4107	998	21	the	the	DT
en-wikipedia-org-4107	998	22	Phase	Phase	NNP
en-wikipedia-org-4107	998	23	3	3	CD
en-wikipedia-org-4107	998	24	controlled	control	VBN
en-wikipedia-org-4107	998	25	study	study	NN
en-wikipedia-org-4107	998	26	conducted	conduct	VBN
en-wikipedia-org-4107	998	27	in	in	IN
en-wikipedia-org-4107	998	28	108	108	CD
en-wikipedia-org-4107	998	29	patients	patient	NNS
en-wikipedia-org-4107	998	30	with	with	IN
en-wikipedia-org-4107	998	31	ADHD	ADHD	NNP
en-wikipedia-org-4107	998	32	(	(	-LRB-
en-wikipedia-org-4107	998	33	aged	age	VBN
en-wikipedia-org-4107	998	34	6	6	CD
en-wikipedia-org-4107	998	35	to	to	TO
en-wikipedia-org-4107	998	36	12	12	CD
en-wikipedia-org-4107	998	37	years	year	NNS
en-wikipedia-org-4107	998	38	)	)	-RRB-
en-wikipedia-org-4107	998	39	were	be	VBD
en-wikipedia-org-4107	998	40	:	:	:
en-wikipedia-org-4107	998	41	epistaxis	epistaxis	JJ
en-wikipedia-org-4107	998	42	,	,	,
en-wikipedia-org-4107	998	43	allergic	allergic	JJ
en-wikipedia-org-4107	998	44	rhinitis	rhinitis	NNP
en-wikipedia-org-4107	998	45	and	and	CC
en-wikipedia-org-4107	998	46	upper	upper	JJ
en-wikipedia-org-4107	998	47	abdominal	abdominal	JJ
en-wikipedia-org-4107	998	48	pain	pain	NN
en-wikipedia-org-4107	998	49	.	.	.
en-wikipedia-org-4107	999	1	...	...	NFP
en-wikipedia-org-4107	1000	1	DOSAGE	dosage	JJ
en-wikipedia-org-4107	1000	2	FORMS	form	NNS
en-wikipedia-org-4107	1000	3	AND	and	CC
en-wikipedia-org-4107	1000	4	STRENGTHS	strength	VBZ
en-wikipedia-org-4107	1000	5	Extended	extended	JJ
en-wikipedia-org-4107	1000	6	-	-	HYPH
en-wikipedia-org-4107	1000	7	release	release	NN
en-wikipedia-org-4107	1000	8	oral	oral	JJ
en-wikipedia-org-4107	1000	9	suspension	suspension	NN
en-wikipedia-org-4107	1000	10	contains	contain	VBZ
en-wikipedia-org-4107	1000	11	2.5	2.5	CD
en-wikipedia-org-4107	1000	12	mg	mg	NNP
en-wikipedia-org-4107	1000	13	amphetamine	amphetamine	VB
en-wikipedia-org-4107	1000	14	base	base	NN
en-wikipedia-org-4107	1000	15	equivalents	equivalent	NNS
en-wikipedia-org-4107	1000	16	per	per	IN
en-wikipedia-org-4107	1000	17	mL.	ml.	NN
en-wikipedia-org-4107	1001	1	^	^	NNP
en-wikipedia-org-4107	1001	2	Ramey	Ramey	NNP
en-wikipedia-org-4107	1001	3	JT	JT	NNP
en-wikipedia-org-4107	1001	4	,	,	,
en-wikipedia-org-4107	1001	5	Bailen	Bailen	NNP
en-wikipedia-org-4107	1001	6	E	E	NNP
en-wikipedia-org-4107	1001	7	,	,	,
en-wikipedia-org-4107	1001	8	Lockey	Lockey	NNP
en-wikipedia-org-4107	1001	9	RF	RF	NNP
en-wikipedia-org-4107	1001	10	(	(	-LRB-
en-wikipedia-org-4107	1001	11	2006	2006	CD
en-wikipedia-org-4107	1001	12	)	)	-RRB-
en-wikipedia-org-4107	1001	13	.	.	.
en-wikipedia-org-4107	1002	1	"	"	``
en-wikipedia-org-4107	1002	2	Rhinitis	rhinitis	JJ
en-wikipedia-org-4107	1002	3	medicamentosa	medicamentosa	NN
en-wikipedia-org-4107	1002	4	"	"	''
en-wikipedia-org-4107	1002	5	(	(	-LRB-
en-wikipedia-org-4107	1002	6	PDF	PDF	NNP
en-wikipedia-org-4107	1002	7	)	)	-RRB-
en-wikipedia-org-4107	1002	8	.	.	.
en-wikipedia-org-4107	1003	1	Journal	Journal	NNP
en-wikipedia-org-4107	1003	2	of	of	IN
en-wikipedia-org-4107	1003	3	Investigational	Investigational	NNP
en-wikipedia-org-4107	1003	4	Allergology	Allergology	NNP
en-wikipedia-org-4107	1003	5	&	&	CC
en-wikipedia-org-4107	1003	6	Clinical	Clinical	NNP
en-wikipedia-org-4107	1003	7	Immunology	Immunology	NNP
en-wikipedia-org-4107	1003	8	.	.	.
en-wikipedia-org-4107	1004	1	16	16	CD
en-wikipedia-org-4107	1004	2	(	(	-LRB-
en-wikipedia-org-4107	1004	3	3	3	CD
en-wikipedia-org-4107	1004	4	)	)	-RRB-
en-wikipedia-org-4107	1004	5	:	:	:
en-wikipedia-org-4107	1004	6	148–155	148–155	CD
en-wikipedia-org-4107	1004	7	.	.	.
en-wikipedia-org-4107	1005	1	PMID	PMID	NNP
en-wikipedia-org-4107	1005	2	 	  	_SP
en-wikipedia-org-4107	1005	3	16784007	16784007	CD
en-wikipedia-org-4107	1005	4	.	.	.
en-wikipedia-org-4107	1006	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1006	2	29	29	CD
en-wikipedia-org-4107	1006	3	April	April	NNP
en-wikipedia-org-4107	1006	4	2015	2015	CD
en-wikipedia-org-4107	1006	5	.	.	.
en-wikipedia-org-4107	1007	1	Table	table	NN
en-wikipedia-org-4107	1007	2	2	2	CD
en-wikipedia-org-4107	1007	3	.	.	.
en-wikipedia-org-4107	1008	1	Decongestants	decongestant	NNS
en-wikipedia-org-4107	1008	2	Causing	cause	VBG
en-wikipedia-org-4107	1008	3	Rhinitis	Rhinitis	NNP
en-wikipedia-org-4107	1008	4	Medicamentosa	Medicamentosa	NNP
en-wikipedia-org-4107	1008	5	–	–	:
en-wikipedia-org-4107	1008	6	Nasal	nasal	NN
en-wikipedia-org-4107	1008	7	decongestants	decongestant	VBZ
en-wikipedia-org-4107	1008	8	:	:	:
en-wikipedia-org-4107	1008	9	 	  	_SP
en-wikipedia-org-4107	1008	10	–	–	:
en-wikipedia-org-4107	1008	11	Sympathomimetic	sympathomimetic	JJ
en-wikipedia-org-4107	1008	12	:	:	:
en-wikipedia-org-4107	1008	13	   	   	_SP
en-wikipedia-org-4107	1008	14	•	•	NNP
en-wikipedia-org-4107	1008	15	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1008	16	^	^	VBD
en-wikipedia-org-4107	1008	17	a	a	DT
en-wikipedia-org-4107	1008	18	b	b	NN
en-wikipedia-org-4107	1008	19	"	"	``
en-wikipedia-org-4107	1008	20	FDA	FDA	NNP
en-wikipedia-org-4107	1008	21	Drug	Drug	NNP
en-wikipedia-org-4107	1008	22	Safety	Safety	NNP
en-wikipedia-org-4107	1008	23	Communication	Communication	NNP
en-wikipedia-org-4107	1008	24	:	:	:
en-wikipedia-org-4107	1008	25	Safety	Safety	NNP
en-wikipedia-org-4107	1008	26	Review	Review	NNP
en-wikipedia-org-4107	1008	27	Update	Update	NNP
en-wikipedia-org-4107	1008	28	of	of	IN
en-wikipedia-org-4107	1008	29	Medications	Medications	NNPS
en-wikipedia-org-4107	1008	30	used	use	VBN
en-wikipedia-org-4107	1008	31	to	to	TO
en-wikipedia-org-4107	1008	32	treat	treat	VB
en-wikipedia-org-4107	1008	33	Attention	attention	NN
en-wikipedia-org-4107	1008	34	-	-	HYPH
en-wikipedia-org-4107	1008	35	Deficit	Deficit	NNP
en-wikipedia-org-4107	1008	36	/	/	SYM
en-wikipedia-org-4107	1008	37	Hyperactivity	Hyperactivity	NNP
en-wikipedia-org-4107	1008	38	Disorder	Disorder	NNP
en-wikipedia-org-4107	1008	39	(	(	-LRB-
en-wikipedia-org-4107	1008	40	ADHD	ADHD	NNP
en-wikipedia-org-4107	1008	41	)	)	-RRB-
en-wikipedia-org-4107	1008	42	in	in	IN
en-wikipedia-org-4107	1008	43	children	child	NNS
en-wikipedia-org-4107	1008	44	and	and	CC
en-wikipedia-org-4107	1008	45	young	young	JJ
en-wikipedia-org-4107	1008	46	adults	adult	NNS
en-wikipedia-org-4107	1008	47	"	"	''
en-wikipedia-org-4107	1008	48	.	.	.
en-wikipedia-org-4107	1009	1	United	United	NNP
en-wikipedia-org-4107	1009	2	States	States	NNP
en-wikipedia-org-4107	1009	3	Food	Food	NNP
en-wikipedia-org-4107	1009	4	and	and	CC
en-wikipedia-org-4107	1009	5	Drug	Drug	NNP
en-wikipedia-org-4107	1009	6	Administration	Administration	NNP
en-wikipedia-org-4107	1009	7	.	.	.
en-wikipedia-org-4107	1010	1	1	1	CD
en-wikipedia-org-4107	1010	2	November	November	NNP
en-wikipedia-org-4107	1010	3	2011	2011	CD
en-wikipedia-org-4107	1010	4	.	.	.
en-wikipedia-org-4107	1011	1	Archived	archived	JJ
en-wikipedia-org-4107	1011	2	from	from	IN
en-wikipedia-org-4107	1011	3	the	the	DT
en-wikipedia-org-4107	1011	4	original	original	NN
en-wikipedia-org-4107	1011	5	on	on	IN
en-wikipedia-org-4107	1011	6	25	25	CD
en-wikipedia-org-4107	1011	7	August	August	NNP
en-wikipedia-org-4107	1011	8	2019	2019	CD
en-wikipedia-org-4107	1011	9	.	.	.
en-wikipedia-org-4107	1012	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1012	2	24	24	CD
en-wikipedia-org-4107	1012	3	December	December	NNP
en-wikipedia-org-4107	1012	4	2019	2019	CD
en-wikipedia-org-4107	1012	5	.	.	.
en-wikipedia-org-4107	1013	1	^	^	NNP
en-wikipedia-org-4107	1013	2	Cooper	Cooper	NNP
en-wikipedia-org-4107	1013	3	WO	WO	NNP
en-wikipedia-org-4107	1013	4	,	,	,
en-wikipedia-org-4107	1013	5	Habel	Habel	NNP
en-wikipedia-org-4107	1013	6	LA	LA	NNP
en-wikipedia-org-4107	1013	7	,	,	,
en-wikipedia-org-4107	1013	8	Sox	Sox	NNP
en-wikipedia-org-4107	1013	9	CM	CM	NNP
en-wikipedia-org-4107	1013	10	,	,	,
en-wikipedia-org-4107	1013	11	Chan	Chan	NNP
en-wikipedia-org-4107	1013	12	KA	KA	NNP
en-wikipedia-org-4107	1013	13	,	,	,
en-wikipedia-org-4107	1013	14	Arbogast	Arbogast	NNP
en-wikipedia-org-4107	1013	15	PG	PG	NNP
en-wikipedia-org-4107	1013	16	,	,	,
en-wikipedia-org-4107	1013	17	Cheetham	Cheetham	NNP
en-wikipedia-org-4107	1013	18	TC	TC	NNP
en-wikipedia-org-4107	1013	19	,	,	,
en-wikipedia-org-4107	1013	20	Murray	Murray	NNP
en-wikipedia-org-4107	1013	21	KT	KT	NNP
en-wikipedia-org-4107	1013	22	,	,	,
en-wikipedia-org-4107	1013	23	Quinn	Quinn	NNP
en-wikipedia-org-4107	1013	24	VP	VP	NNP
en-wikipedia-org-4107	1013	25	,	,	,
en-wikipedia-org-4107	1013	26	Stein	Stein	NNP
en-wikipedia-org-4107	1013	27	CM	CM	NNP
en-wikipedia-org-4107	1013	28	,	,	,
en-wikipedia-org-4107	1013	29	Callahan	Callahan	NNP
en-wikipedia-org-4107	1013	30	ST	ST	NNP
en-wikipedia-org-4107	1013	31	,	,	,
en-wikipedia-org-4107	1013	32	Fireman	Fireman	NNP
en-wikipedia-org-4107	1013	33	BH	BH	NNP
en-wikipedia-org-4107	1013	34	,	,	,
en-wikipedia-org-4107	1013	35	Fish	fish	NN
en-wikipedia-org-4107	1013	36	FA	FA	NNP
en-wikipedia-org-4107	1013	37	,	,	,
en-wikipedia-org-4107	1013	38	Kirshner	Kirshner	NNP
en-wikipedia-org-4107	1013	39	HS	HS	NNP
en-wikipedia-org-4107	1013	40	,	,	,
en-wikipedia-org-4107	1013	41	O'Duffy	O'Duffy	NNP
en-wikipedia-org-4107	1013	42	A	A	NNP
en-wikipedia-org-4107	1013	43	,	,	,
en-wikipedia-org-4107	1013	44	Connell	Connell	NNP
en-wikipedia-org-4107	1013	45	FA	FA	NNP
en-wikipedia-org-4107	1013	46	,	,	,
en-wikipedia-org-4107	1013	47	Ray	Ray	NNP
en-wikipedia-org-4107	1013	48	WA	WA	NNP
en-wikipedia-org-4107	1013	49	(	(	-LRB-
en-wikipedia-org-4107	1013	50	November	November	NNP
en-wikipedia-org-4107	1013	51	2011	2011	CD
en-wikipedia-org-4107	1013	52	)	)	-RRB-
en-wikipedia-org-4107	1013	53	.	.	.
en-wikipedia-org-4107	1014	1	"	"	``
en-wikipedia-org-4107	1014	2	ADHD	adhd	JJ
en-wikipedia-org-4107	1014	3	drugs	drug	NNS
en-wikipedia-org-4107	1014	4	and	and	CC
en-wikipedia-org-4107	1014	5	serious	serious	JJ
en-wikipedia-org-4107	1014	6	cardiovascular	cardiovascular	JJ
en-wikipedia-org-4107	1014	7	events	event	NNS
en-wikipedia-org-4107	1014	8	in	in	IN
en-wikipedia-org-4107	1014	9	children	child	NNS
en-wikipedia-org-4107	1014	10	and	and	CC
en-wikipedia-org-4107	1014	11	young	young	JJ
en-wikipedia-org-4107	1014	12	adults	adult	NNS
en-wikipedia-org-4107	1014	13	"	"	''
en-wikipedia-org-4107	1014	14	.	.	.
en-wikipedia-org-4107	1015	1	New	New	NNP
en-wikipedia-org-4107	1015	2	England	England	NNP
en-wikipedia-org-4107	1015	3	Journal	Journal	NNP
en-wikipedia-org-4107	1015	4	of	of	IN
en-wikipedia-org-4107	1015	5	Medicine	Medicine	NNP
en-wikipedia-org-4107	1015	6	.	.	.
en-wikipedia-org-4107	1016	1	365	365	CD
en-wikipedia-org-4107	1016	2	(	(	-LRB-
en-wikipedia-org-4107	1016	3	20	20	CD
en-wikipedia-org-4107	1016	4	)	)	-RRB-
en-wikipedia-org-4107	1016	5	:	:	:
en-wikipedia-org-4107	1016	6	1896–1904	1896–1904	CD
en-wikipedia-org-4107	1016	7	.	.	.
en-wikipedia-org-4107	1017	1	doi:10.1056	doi:10.1056	RB
en-wikipedia-org-4107	1017	2	/	/	SYM
en-wikipedia-org-4107	1017	3	NEJMoa1110212	nejmoa1110212	UH
en-wikipedia-org-4107	1017	4	.	.	.
en-wikipedia-org-4107	1018	1	PMC	PMC	NNP
en-wikipedia-org-4107	1018	2	 	  	_SP
en-wikipedia-org-4107	1018	3	4943074	4943074	CD
en-wikipedia-org-4107	1018	4	.	.	.
en-wikipedia-org-4107	1019	1	PMID	PMID	NNP
en-wikipedia-org-4107	1019	2	 	  	_SP
en-wikipedia-org-4107	1019	3	22043968	22043968	CD
en-wikipedia-org-4107	1019	4	.	.	.
en-wikipedia-org-4107	1020	1	^	^	NNP
en-wikipedia-org-4107	1020	2	a	a	DT
en-wikipedia-org-4107	1020	3	b	b	NNP
en-wikipedia-org-4107	1020	4	"	"	``
en-wikipedia-org-4107	1020	5	FDA	FDA	NNP
en-wikipedia-org-4107	1020	6	Drug	Drug	NNP
en-wikipedia-org-4107	1020	7	Safety	Safety	NNP
en-wikipedia-org-4107	1020	8	Communication	Communication	NNP
en-wikipedia-org-4107	1020	9	:	:	:
en-wikipedia-org-4107	1020	10	Safety	Safety	NNP
en-wikipedia-org-4107	1020	11	Review	Review	NNP
en-wikipedia-org-4107	1020	12	Update	Update	NNP
en-wikipedia-org-4107	1020	13	of	of	IN
en-wikipedia-org-4107	1020	14	Medications	Medications	NNPS
en-wikipedia-org-4107	1020	15	used	use	VBN
en-wikipedia-org-4107	1020	16	to	to	TO
en-wikipedia-org-4107	1020	17	treat	treat	VB
en-wikipedia-org-4107	1020	18	Attention	attention	NN
en-wikipedia-org-4107	1020	19	-	-	HYPH
en-wikipedia-org-4107	1020	20	Deficit	Deficit	NNP
en-wikipedia-org-4107	1020	21	/	/	SYM
en-wikipedia-org-4107	1020	22	Hyperactivity	Hyperactivity	NNP
en-wikipedia-org-4107	1020	23	Disorder	Disorder	NNP
en-wikipedia-org-4107	1020	24	(	(	-LRB-
en-wikipedia-org-4107	1020	25	ADHD	ADHD	NNP
en-wikipedia-org-4107	1020	26	)	)	-RRB-
en-wikipedia-org-4107	1020	27	in	in	IN
en-wikipedia-org-4107	1020	28	adults	adult	NNS
en-wikipedia-org-4107	1020	29	"	"	''
en-wikipedia-org-4107	1020	30	.	.	.
en-wikipedia-org-4107	1021	1	United	United	NNP
en-wikipedia-org-4107	1021	2	States	States	NNP
en-wikipedia-org-4107	1021	3	Food	Food	NNP
en-wikipedia-org-4107	1021	4	and	and	CC
en-wikipedia-org-4107	1021	5	Drug	Drug	NNP
en-wikipedia-org-4107	1021	6	Administration	Administration	NNP
en-wikipedia-org-4107	1021	7	.	.	.
en-wikipedia-org-4107	1022	1	12	12	CD
en-wikipedia-org-4107	1022	2	December	December	NNP
en-wikipedia-org-4107	1022	3	2011	2011	CD
en-wikipedia-org-4107	1022	4	.	.	.
en-wikipedia-org-4107	1023	1	Archived	archived	JJ
en-wikipedia-org-4107	1023	2	from	from	IN
en-wikipedia-org-4107	1023	3	the	the	DT
en-wikipedia-org-4107	1023	4	original	original	NN
en-wikipedia-org-4107	1023	5	on	on	IN
en-wikipedia-org-4107	1023	6	14	14	CD
en-wikipedia-org-4107	1023	7	December	December	NNP
en-wikipedia-org-4107	1023	8	2019	2019	CD
en-wikipedia-org-4107	1023	9	.	.	.
en-wikipedia-org-4107	1024	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1024	2	24	24	CD
en-wikipedia-org-4107	1024	3	December	December	NNP
en-wikipedia-org-4107	1024	4	2013	2013	CD
en-wikipedia-org-4107	1024	5	.	.	.
en-wikipedia-org-4107	1025	1	^	^	NNP
en-wikipedia-org-4107	1025	2	Habel	Habel	NNP
en-wikipedia-org-4107	1025	3	LA	LA	NNP
en-wikipedia-org-4107	1025	4	,	,	,
en-wikipedia-org-4107	1025	5	Cooper	Cooper	NNP
en-wikipedia-org-4107	1025	6	WO	WO	NNP
en-wikipedia-org-4107	1025	7	,	,	,
en-wikipedia-org-4107	1025	8	Sox	Sox	NNP
en-wikipedia-org-4107	1025	9	CM	CM	NNP
en-wikipedia-org-4107	1025	10	,	,	,
en-wikipedia-org-4107	1025	11	Chan	Chan	NNP
en-wikipedia-org-4107	1025	12	KA	KA	NNP
en-wikipedia-org-4107	1025	13	,	,	,
en-wikipedia-org-4107	1025	14	Fireman	Fireman	NNP
en-wikipedia-org-4107	1025	15	BH	BH	NNP
en-wikipedia-org-4107	1025	16	,	,	,
en-wikipedia-org-4107	1025	17	Arbogast	Arbogast	NNP
en-wikipedia-org-4107	1025	18	PG	PG	NNP
en-wikipedia-org-4107	1025	19	,	,	,
en-wikipedia-org-4107	1025	20	Cheetham	Cheetham	NNP
en-wikipedia-org-4107	1025	21	TC	TC	NNP
en-wikipedia-org-4107	1025	22	,	,	,
en-wikipedia-org-4107	1025	23	Quinn	Quinn	NNP
en-wikipedia-org-4107	1025	24	VP	VP	NNP
en-wikipedia-org-4107	1025	25	,	,	,
en-wikipedia-org-4107	1025	26	Dublin	Dublin	NNP
en-wikipedia-org-4107	1025	27	S	S	NNP
en-wikipedia-org-4107	1025	28	,	,	,
en-wikipedia-org-4107	1025	29	Boudreau	Boudreau	NNP
en-wikipedia-org-4107	1025	30	DM	DM	NNP
en-wikipedia-org-4107	1025	31	,	,	,
en-wikipedia-org-4107	1025	32	Andrade	Andrade	NNP
en-wikipedia-org-4107	1025	33	SE	SE	NNP
en-wikipedia-org-4107	1025	34	,	,	,
en-wikipedia-org-4107	1025	35	Pawloski	Pawloski	NNP
en-wikipedia-org-4107	1025	36	PA	PA	NNP
en-wikipedia-org-4107	1025	37	,	,	,
en-wikipedia-org-4107	1025	38	Raebel	Raebel	NNP
en-wikipedia-org-4107	1025	39	MA	MA	NNP
en-wikipedia-org-4107	1025	40	,	,	,
en-wikipedia-org-4107	1025	41	Smith	Smith	NNP
en-wikipedia-org-4107	1025	42	DH	DH	NNP
en-wikipedia-org-4107	1025	43	,	,	,
en-wikipedia-org-4107	1025	44	Achacoso	Achacoso	NNP
en-wikipedia-org-4107	1025	45	N	N	NNP
en-wikipedia-org-4107	1025	46	,	,	,
en-wikipedia-org-4107	1025	47	Uratsu	Uratsu	NNP
en-wikipedia-org-4107	1025	48	C	C	NNP
en-wikipedia-org-4107	1025	49	,	,	,
en-wikipedia-org-4107	1025	50	Go	go	VB
en-wikipedia-org-4107	1025	51	AS	AS	NNP
en-wikipedia-org-4107	1025	52	,	,	,
en-wikipedia-org-4107	1025	53	Sidney	Sidney	NNP
en-wikipedia-org-4107	1025	54	S	S	NNP
en-wikipedia-org-4107	1025	55	,	,	,
en-wikipedia-org-4107	1025	56	Nguyen	Nguyen	NNP
en-wikipedia-org-4107	1025	57	-	-	HYPH
en-wikipedia-org-4107	1025	58	Huynh	Huynh	NNP
en-wikipedia-org-4107	1025	59	MN	MN	NNP
en-wikipedia-org-4107	1025	60	,	,	,
en-wikipedia-org-4107	1025	61	Ray	Ray	NNP
en-wikipedia-org-4107	1025	62	WA	WA	NNP
en-wikipedia-org-4107	1025	63	,	,	,
en-wikipedia-org-4107	1025	64	Selby	Selby	NNP
en-wikipedia-org-4107	1025	65	JV	JV	NNP
en-wikipedia-org-4107	1025	66	(	(	-LRB-
en-wikipedia-org-4107	1025	67	December	December	NNP
en-wikipedia-org-4107	1025	68	2011	2011	CD
en-wikipedia-org-4107	1025	69	)	)	-RRB-
en-wikipedia-org-4107	1025	70	.	.	.
en-wikipedia-org-4107	1026	1	"	"	``
en-wikipedia-org-4107	1026	2	ADHD	adhd	JJ
en-wikipedia-org-4107	1026	3	medications	medication	NNS
en-wikipedia-org-4107	1026	4	and	and	CC
en-wikipedia-org-4107	1026	5	risk	risk	NN
en-wikipedia-org-4107	1026	6	of	of	IN
en-wikipedia-org-4107	1026	7	serious	serious	JJ
en-wikipedia-org-4107	1026	8	cardiovascular	cardiovascular	JJ
en-wikipedia-org-4107	1026	9	events	event	NNS
en-wikipedia-org-4107	1026	10	in	in	IN
en-wikipedia-org-4107	1026	11	young	young	JJ
en-wikipedia-org-4107	1026	12	and	and	CC
en-wikipedia-org-4107	1026	13	middle	middle	JJ
en-wikipedia-org-4107	1026	14	-	-	HYPH
en-wikipedia-org-4107	1026	15	aged	aged	JJ
en-wikipedia-org-4107	1026	16	adults	adult	NNS
en-wikipedia-org-4107	1026	17	"	"	''
en-wikipedia-org-4107	1026	18	.	.	.
en-wikipedia-org-4107	1027	1	JAMA	JAMA	NNP
en-wikipedia-org-4107	1027	2	.	.	.
en-wikipedia-org-4107	1028	1	306	306	CD
en-wikipedia-org-4107	1028	2	(	(	-LRB-
en-wikipedia-org-4107	1028	3	24	24	CD
en-wikipedia-org-4107	1028	4	)	)	-RRB-
en-wikipedia-org-4107	1028	5	:	:	:
en-wikipedia-org-4107	1028	6	2673–2683	2673–2683	CD
en-wikipedia-org-4107	1028	7	.	.	.
en-wikipedia-org-4107	1029	1	doi:10.1001	doi:10.1001	NNP
en-wikipedia-org-4107	1029	2	/	/	SYM
en-wikipedia-org-4107	1029	3	jama.2011.1830	jama.2011.1830	NNS
en-wikipedia-org-4107	1029	4	.	.	.
en-wikipedia-org-4107	1030	1	PMC	PMC	NNP
en-wikipedia-org-4107	1030	2	 	  	_SP
en-wikipedia-org-4107	1030	3	3350308	3350308	CD
en-wikipedia-org-4107	1030	4	.	.	.
en-wikipedia-org-4107	1031	1	PMID	PMID	NNP
en-wikipedia-org-4107	1031	2	 	  	_SP
en-wikipedia-org-4107	1031	3	22161946	22161946	CD
en-wikipedia-org-4107	1031	4	.	.	.
en-wikipedia-org-4107	1032	1	^	^	NNP
en-wikipedia-org-4107	1032	2	O'Connor	O'Connor	NNP
en-wikipedia-org-4107	1032	3	PG	PG	NNP
en-wikipedia-org-4107	1032	4	(	(	-LRB-
en-wikipedia-org-4107	1032	5	February	February	NNP
en-wikipedia-org-4107	1032	6	2012	2012	CD
en-wikipedia-org-4107	1032	7	)	)	-RRB-
en-wikipedia-org-4107	1032	8	.	.	.
en-wikipedia-org-4107	1033	1	"	"	``
en-wikipedia-org-4107	1033	2	Amphetamines	Amphetamines	NNPS
en-wikipedia-org-4107	1033	3	"	"	''
en-wikipedia-org-4107	1033	4	.	.	.
en-wikipedia-org-4107	1034	1	Merck	Merck	NNP
en-wikipedia-org-4107	1034	2	Manual	Manual	NNP
en-wikipedia-org-4107	1034	3	for	for	IN
en-wikipedia-org-4107	1034	4	Health	Health	NNP
en-wikipedia-org-4107	1034	5	Care	Care	NNP
en-wikipedia-org-4107	1034	6	Professionals	Professionals	NNP
en-wikipedia-org-4107	1034	7	.	.	.
en-wikipedia-org-4107	1035	1	Merck	Merck	NNP
en-wikipedia-org-4107	1035	2	.	.	.
en-wikipedia-org-4107	1036	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1036	2	8	8	CD
en-wikipedia-org-4107	1036	3	May	May	NNP
en-wikipedia-org-4107	1036	4	2012	2012	CD
en-wikipedia-org-4107	1036	5	.	.	.
en-wikipedia-org-4107	1037	1	^	^	NNP
en-wikipedia-org-4107	1037	2	a	a	DT
en-wikipedia-org-4107	1037	3	b	b	NNP
en-wikipedia-org-4107	1037	4	Childs	Childs	NNP
en-wikipedia-org-4107	1037	5	E	E	NNP
en-wikipedia-org-4107	1037	6	,	,	,
en-wikipedia-org-4107	1037	7	de	de	NNP
en-wikipedia-org-4107	1037	8	Wit	Wit	NNP
en-wikipedia-org-4107	1037	9	H	H	NNP
en-wikipedia-org-4107	1037	10	(	(	-LRB-
en-wikipedia-org-4107	1037	11	May	May	NNP
en-wikipedia-org-4107	1037	12	2009	2009	CD
en-wikipedia-org-4107	1037	13	)	)	-RRB-
en-wikipedia-org-4107	1037	14	.	.	.
en-wikipedia-org-4107	1038	1	"	"	``
en-wikipedia-org-4107	1038	2	Amphetamine	amphetamine	NN
en-wikipedia-org-4107	1038	3	-	-	HYPH
en-wikipedia-org-4107	1038	4	induced	induce	VBN
en-wikipedia-org-4107	1038	5	place	place	NN
en-wikipedia-org-4107	1038	6	preference	preference	NN
en-wikipedia-org-4107	1038	7	in	in	IN
en-wikipedia-org-4107	1038	8	humans	human	NNS
en-wikipedia-org-4107	1038	9	"	"	''
en-wikipedia-org-4107	1038	10	.	.	.
en-wikipedia-org-4107	1039	1	Biological	biological	JJ
en-wikipedia-org-4107	1039	2	Psychiatry	Psychiatry	NNP
en-wikipedia-org-4107	1039	3	.	.	.
en-wikipedia-org-4107	1040	1	65	65	CD
en-wikipedia-org-4107	1040	2	(	(	-LRB-
en-wikipedia-org-4107	1040	3	10	10	CD
en-wikipedia-org-4107	1040	4	)	)	-RRB-
en-wikipedia-org-4107	1040	5	:	:	:
en-wikipedia-org-4107	1040	6	900–904	900–904	CD
en-wikipedia-org-4107	1040	7	.	.	.
en-wikipedia-org-4107	1041	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1041	2	/	/	SYM
en-wikipedia-org-4107	1041	3	j.biopsych.2008.11.016	j.biopsych.2008.11.016	JJ
en-wikipedia-org-4107	1041	4	.	.	.
en-wikipedia-org-4107	1042	1	PMC	PMC	NNP
en-wikipedia-org-4107	1042	2	 	  	_SP
en-wikipedia-org-4107	1042	3	2693956	2693956	CD
en-wikipedia-org-4107	1042	4	.	.	.
en-wikipedia-org-4107	1043	1	PMID	PMID	NNP
en-wikipedia-org-4107	1043	2	 	  	_SP
en-wikipedia-org-4107	1043	3	19111278	19111278	CD
en-wikipedia-org-4107	1043	4	.	.	.
en-wikipedia-org-4107	1044	1	This	this	DT
en-wikipedia-org-4107	1044	2	study	study	NN
en-wikipedia-org-4107	1044	3	demonstrates	demonstrate	VBZ
en-wikipedia-org-4107	1044	4	that	that	IN
en-wikipedia-org-4107	1044	5	humans	human	NNS
en-wikipedia-org-4107	1044	6	,	,	,
en-wikipedia-org-4107	1044	7	like	like	IN
en-wikipedia-org-4107	1044	8	nonhumans	nonhumans	NNPS
en-wikipedia-org-4107	1044	9	,	,	,
en-wikipedia-org-4107	1044	10	prefer	prefer	VBP
en-wikipedia-org-4107	1044	11	a	a	DT
en-wikipedia-org-4107	1044	12	place	place	NN
en-wikipedia-org-4107	1044	13	associated	associate	VBN
en-wikipedia-org-4107	1044	14	with	with	IN
en-wikipedia-org-4107	1044	15	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1044	16	administration	administration	NNP
en-wikipedia-org-4107	1044	17	.	.	.
en-wikipedia-org-4107	1045	1	These	these	DT
en-wikipedia-org-4107	1045	2	findings	finding	NNS
en-wikipedia-org-4107	1045	3	support	support	VBP
en-wikipedia-org-4107	1045	4	the	the	DT
en-wikipedia-org-4107	1045	5	idea	idea	NN
en-wikipedia-org-4107	1045	6	that	that	IN
en-wikipedia-org-4107	1045	7	subjective	subjective	JJ
en-wikipedia-org-4107	1045	8	responses	response	NNS
en-wikipedia-org-4107	1045	9	to	to	IN
en-wikipedia-org-4107	1045	10	a	a	DT
en-wikipedia-org-4107	1045	11	drug	drug	NN
en-wikipedia-org-4107	1045	12	contribute	contribute	VB
en-wikipedia-org-4107	1045	13	to	to	IN
en-wikipedia-org-4107	1045	14	its	-PRON-	PRP$
en-wikipedia-org-4107	1045	15	ability	ability	NN
en-wikipedia-org-4107	1045	16	to	to	TO
en-wikipedia-org-4107	1045	17	establish	establish	VB
en-wikipedia-org-4107	1045	18	place	place	NN
en-wikipedia-org-4107	1045	19	conditioning	conditioning	NN
en-wikipedia-org-4107	1045	20	.	.	.
en-wikipedia-org-4107	1046	1	^	^	NNP
en-wikipedia-org-4107	1046	2	a	a	DT
en-wikipedia-org-4107	1046	3	b	b	NNP
en-wikipedia-org-4107	1046	4	Malenka	Malenka	NNP
en-wikipedia-org-4107	1046	5	RC	RC	NNP
en-wikipedia-org-4107	1046	6	,	,	,
en-wikipedia-org-4107	1046	7	Nestler	Nestler	NNP
en-wikipedia-org-4107	1046	8	EJ	EJ	NNP
en-wikipedia-org-4107	1046	9	,	,	,
en-wikipedia-org-4107	1046	10	Hyman	Hyman	NNP
en-wikipedia-org-4107	1046	11	SE	SE	NNP
en-wikipedia-org-4107	1046	12	(	(	-LRB-
en-wikipedia-org-4107	1046	13	2009	2009	CD
en-wikipedia-org-4107	1046	14	)	)	-RRB-
en-wikipedia-org-4107	1046	15	.	.	.
en-wikipedia-org-4107	1047	1	"	"	``
en-wikipedia-org-4107	1047	2	Chapter	chapter	NN
en-wikipedia-org-4107	1047	3	15	15	CD
en-wikipedia-org-4107	1047	4	:	:	:
en-wikipedia-org-4107	1047	5	Reinforcement	reinforcement	NN
en-wikipedia-org-4107	1047	6	and	and	CC
en-wikipedia-org-4107	1047	7	Addictive	Addictive	NNP
en-wikipedia-org-4107	1047	8	Disorders	Disorders	NNPS
en-wikipedia-org-4107	1047	9	"	"	''
en-wikipedia-org-4107	1047	10	.	.	.
en-wikipedia-org-4107	1048	1	In	in	IN
en-wikipedia-org-4107	1048	2	Sydor	Sydor	NNP
en-wikipedia-org-4107	1048	3	A	A	NNP
en-wikipedia-org-4107	1048	4	,	,	,
en-wikipedia-org-4107	1048	5	Brown	Brown	NNP
en-wikipedia-org-4107	1048	6	RY	RY	NNP
en-wikipedia-org-4107	1048	7	(	(	-LRB-
en-wikipedia-org-4107	1048	8	eds	eds	NNP
en-wikipedia-org-4107	1048	9	.	.	.
en-wikipedia-org-4107	1048	10	)	)	-RRB-
en-wikipedia-org-4107	1048	11	.	.	.
en-wikipedia-org-4107	1049	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	1049	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-4107	1049	3	:	:	:
en-wikipedia-org-4107	1049	4	A	A	NNP
en-wikipedia-org-4107	1049	5	Foundation	Foundation	NNP
en-wikipedia-org-4107	1049	6	for	for	IN
en-wikipedia-org-4107	1049	7	Clinical	Clinical	NNP
en-wikipedia-org-4107	1049	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1049	9	(	(	-LRB-
en-wikipedia-org-4107	1049	10	2nd	2nd	NNP
en-wikipedia-org-4107	1049	11	ed	ed	NNP
en-wikipedia-org-4107	1049	12	.	.	.
en-wikipedia-org-4107	1049	13	)	)	-RRB-
en-wikipedia-org-4107	1049	14	.	.	.
en-wikipedia-org-4107	1050	1	New	New	NNP
en-wikipedia-org-4107	1050	2	York	York	NNP
en-wikipedia-org-4107	1050	3	:	:	:
en-wikipedia-org-4107	1050	4	McGraw	McGraw	NNP
en-wikipedia-org-4107	1050	5	-	-	HYPH
en-wikipedia-org-4107	1050	6	Hill	Hill	NNP
en-wikipedia-org-4107	1050	7	Medical	Medical	NNP
en-wikipedia-org-4107	1050	8	.	.	.
en-wikipedia-org-4107	1051	1	pp	pp	NNP
en-wikipedia-org-4107	1051	2	.	.	.
en-wikipedia-org-4107	1052	1	364–375	364–375	CD
en-wikipedia-org-4107	1052	2	.	.	.
en-wikipedia-org-4107	1053	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	1053	2	 	  	_SP
en-wikipedia-org-4107	1053	3	9780071481274	9780071481274	CD
en-wikipedia-org-4107	1053	4	.	.	.
en-wikipedia-org-4107	1054	1	^	^	NNP
en-wikipedia-org-4107	1054	2	a	a	DT
en-wikipedia-org-4107	1054	3	b	b	NNP
en-wikipedia-org-4107	1054	4	c	c	NN
en-wikipedia-org-4107	1054	5	d	d	NNP
en-wikipedia-org-4107	1054	6	e	e	NNP
en-wikipedia-org-4107	1054	7	Nestler	Nestler	NNP
en-wikipedia-org-4107	1054	8	EJ	EJ	NNP
en-wikipedia-org-4107	1054	9	(	(	-LRB-
en-wikipedia-org-4107	1054	10	December	December	NNP
en-wikipedia-org-4107	1054	11	2013	2013	CD
en-wikipedia-org-4107	1054	12	)	)	-RRB-
en-wikipedia-org-4107	1054	13	.	.	.
en-wikipedia-org-4107	1055	1	"	"	``
en-wikipedia-org-4107	1055	2	Cellular	cellular	JJ
en-wikipedia-org-4107	1055	3	basis	basis	NN
en-wikipedia-org-4107	1055	4	of	of	IN
en-wikipedia-org-4107	1055	5	memory	memory	NN
en-wikipedia-org-4107	1055	6	for	for	IN
en-wikipedia-org-4107	1055	7	addiction	addiction	NN
en-wikipedia-org-4107	1055	8	"	"	''
en-wikipedia-org-4107	1055	9	.	.	.
en-wikipedia-org-4107	1056	1	Dialogues	dialogue	NNS
en-wikipedia-org-4107	1056	2	in	in	IN
en-wikipedia-org-4107	1056	3	Clinical	Clinical	NNP
en-wikipedia-org-4107	1056	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1056	5	.	.	.
en-wikipedia-org-4107	1057	1	15	15	CD
en-wikipedia-org-4107	1057	2	(	(	-LRB-
en-wikipedia-org-4107	1057	3	4	4	CD
en-wikipedia-org-4107	1057	4	)	)	-RRB-
en-wikipedia-org-4107	1057	5	:	:	:
en-wikipedia-org-4107	1057	6	431–443	431–443	CD
en-wikipedia-org-4107	1057	7	.	.	.
en-wikipedia-org-4107	1058	1	PMC	PMC	NNP
en-wikipedia-org-4107	1058	2	 	  	_SP
en-wikipedia-org-4107	1058	3	3898681	3898681	CD
en-wikipedia-org-4107	1058	4	.	.	.
en-wikipedia-org-4107	1059	1	PMID	PMID	NNP
en-wikipedia-org-4107	1059	2	 	  	_SP
en-wikipedia-org-4107	1059	3	24459410	24459410	CD
en-wikipedia-org-4107	1059	4	.	.	.
en-wikipedia-org-4107	1060	1	Despite	despite	IN
en-wikipedia-org-4107	1060	2	the	the	DT
en-wikipedia-org-4107	1060	3	importance	importance	NN
en-wikipedia-org-4107	1060	4	of	of	IN
en-wikipedia-org-4107	1060	5	numerous	numerous	JJ
en-wikipedia-org-4107	1060	6	psychosocial	psychosocial	JJ
en-wikipedia-org-4107	1060	7	factors	factor	NNS
en-wikipedia-org-4107	1060	8	,	,	,
en-wikipedia-org-4107	1060	9	at	at	IN
en-wikipedia-org-4107	1060	10	its	-PRON-	PRP$
en-wikipedia-org-4107	1060	11	core	core	NN
en-wikipedia-org-4107	1060	12	,	,	,
en-wikipedia-org-4107	1060	13	drug	drug	NN
en-wikipedia-org-4107	1060	14	addiction	addiction	NN
en-wikipedia-org-4107	1060	15	involves	involve	VBZ
en-wikipedia-org-4107	1060	16	a	a	DT
en-wikipedia-org-4107	1060	17	biological	biological	JJ
en-wikipedia-org-4107	1060	18	process	process	NN
en-wikipedia-org-4107	1060	19	:	:	:
en-wikipedia-org-4107	1060	20	the	the	DT
en-wikipedia-org-4107	1060	21	ability	ability	NN
en-wikipedia-org-4107	1060	22	of	of	IN
en-wikipedia-org-4107	1060	23	repeated	repeat	VBN
en-wikipedia-org-4107	1060	24	exposure	exposure	NN
en-wikipedia-org-4107	1060	25	to	to	IN
en-wikipedia-org-4107	1060	26	a	a	DT
en-wikipedia-org-4107	1060	27	drug	drug	NN
en-wikipedia-org-4107	1060	28	of	of	IN
en-wikipedia-org-4107	1060	29	abuse	abuse	NN
en-wikipedia-org-4107	1060	30	to	to	TO
en-wikipedia-org-4107	1060	31	induce	induce	VB
en-wikipedia-org-4107	1060	32	changes	change	NNS
en-wikipedia-org-4107	1060	33	in	in	IN
en-wikipedia-org-4107	1060	34	a	a	DT
en-wikipedia-org-4107	1060	35	vulnerable	vulnerable	JJ
en-wikipedia-org-4107	1060	36	brain	brain	NN
en-wikipedia-org-4107	1060	37	that	that	WDT
en-wikipedia-org-4107	1060	38	drive	drive	VBP
en-wikipedia-org-4107	1060	39	the	the	DT
en-wikipedia-org-4107	1060	40	compulsive	compulsive	JJ
en-wikipedia-org-4107	1060	41	seeking	seeking	NN
en-wikipedia-org-4107	1060	42	and	and	CC
en-wikipedia-org-4107	1060	43	taking	taking	NN
en-wikipedia-org-4107	1060	44	of	of	IN
en-wikipedia-org-4107	1060	45	drugs	drug	NNS
en-wikipedia-org-4107	1060	46	,	,	,
en-wikipedia-org-4107	1060	47	and	and	CC
en-wikipedia-org-4107	1060	48	loss	loss	NN
en-wikipedia-org-4107	1060	49	of	of	IN
en-wikipedia-org-4107	1060	50	control	control	NN
en-wikipedia-org-4107	1060	51	over	over	IN
en-wikipedia-org-4107	1060	52	drug	drug	NN
en-wikipedia-org-4107	1060	53	use	use	NN
en-wikipedia-org-4107	1060	54	,	,	,
en-wikipedia-org-4107	1060	55	that	that	WDT
en-wikipedia-org-4107	1060	56	define	define	VBP
en-wikipedia-org-4107	1060	57	a	a	DT
en-wikipedia-org-4107	1060	58	state	state	NN
en-wikipedia-org-4107	1060	59	of	of	IN
en-wikipedia-org-4107	1060	60	addiction	addiction	NN
en-wikipedia-org-4107	1060	61	.	.	.
en-wikipedia-org-4107	1061	1	...	...	:
en-wikipedia-org-4107	1061	2	A	a	DT
en-wikipedia-org-4107	1061	3	large	large	JJ
en-wikipedia-org-4107	1061	4	body	body	NN
en-wikipedia-org-4107	1061	5	of	of	IN
en-wikipedia-org-4107	1061	6	literature	literature	NN
en-wikipedia-org-4107	1061	7	has	have	VBZ
en-wikipedia-org-4107	1061	8	demonstrated	demonstrate	VBN
en-wikipedia-org-4107	1061	9	that	that	IN
en-wikipedia-org-4107	1061	10	such	such	JJ
en-wikipedia-org-4107	1061	11	ΔFosB	ΔFosB	VBN
en-wikipedia-org-4107	1061	12	induction	induction	NN
en-wikipedia-org-4107	1061	13	in	in	IN
en-wikipedia-org-4107	1061	14	D1-type	D1-type	NNP
en-wikipedia-org-4107	1061	15	[	[	-LRB-
en-wikipedia-org-4107	1061	16	nucleus	nucleus	NNP
en-wikipedia-org-4107	1061	17	accumbens	accumbens	NNPS
en-wikipedia-org-4107	1061	18	]	]	-RRB-
en-wikipedia-org-4107	1061	19	neurons	neuron	NNS
en-wikipedia-org-4107	1061	20	increases	increase	VBZ
en-wikipedia-org-4107	1061	21	an	an	DT
en-wikipedia-org-4107	1061	22	animal	animal	NN
en-wikipedia-org-4107	1061	23	's	's	POS
en-wikipedia-org-4107	1061	24	sensitivity	sensitivity	NN
en-wikipedia-org-4107	1061	25	to	to	IN
en-wikipedia-org-4107	1061	26	drug	drug	NN
en-wikipedia-org-4107	1061	27	as	as	RB
en-wikipedia-org-4107	1061	28	well	well	RB
en-wikipedia-org-4107	1061	29	as	as	IN
en-wikipedia-org-4107	1061	30	natural	natural	JJ
en-wikipedia-org-4107	1061	31	rewards	reward	NNS
en-wikipedia-org-4107	1061	32	and	and	CC
en-wikipedia-org-4107	1061	33	promotes	promote	VBZ
en-wikipedia-org-4107	1061	34	drug	drug	NN
en-wikipedia-org-4107	1061	35	self	self	NN
en-wikipedia-org-4107	1061	36	-	-	HYPH
en-wikipedia-org-4107	1061	37	administration	administration	NN
en-wikipedia-org-4107	1061	38	,	,	,
en-wikipedia-org-4107	1061	39	presumably	presumably	RB
en-wikipedia-org-4107	1061	40	through	through	IN
en-wikipedia-org-4107	1061	41	a	a	DT
en-wikipedia-org-4107	1061	42	process	process	NN
en-wikipedia-org-4107	1061	43	of	of	IN
en-wikipedia-org-4107	1061	44	positive	positive	JJ
en-wikipedia-org-4107	1061	45	reinforcement	reinforcement	NN
en-wikipedia-org-4107	1061	46	 	  	_SP
en-wikipedia-org-4107	1061	47	...	...	:
en-wikipedia-org-4107	1061	48	Another	another	DT
en-wikipedia-org-4107	1061	49	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1061	50	target	target	NN
en-wikipedia-org-4107	1061	51	is	be	VBZ
en-wikipedia-org-4107	1061	52	cFos	cFos	NNP
en-wikipedia-org-4107	1061	53	:	:	:
en-wikipedia-org-4107	1061	54	as	as	IN
en-wikipedia-org-4107	1061	55	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1061	56	accumulates	accumulate	NNS
en-wikipedia-org-4107	1061	57	with	with	IN
en-wikipedia-org-4107	1061	58	repeated	repeat	VBN
en-wikipedia-org-4107	1061	59	drug	drug	NN
en-wikipedia-org-4107	1061	60	exposure	exposure	NN
en-wikipedia-org-4107	1061	61	it	-PRON-	PRP
en-wikipedia-org-4107	1061	62	represses	repress	VBZ
en-wikipedia-org-4107	1061	63	c	c	NN
en-wikipedia-org-4107	1061	64	-	-	:
en-wikipedia-org-4107	1061	65	Fos	fos	NN
en-wikipedia-org-4107	1061	66	and	and	CC
en-wikipedia-org-4107	1061	67	contributes	contribute	VBZ
en-wikipedia-org-4107	1061	68	to	to	IN
en-wikipedia-org-4107	1061	69	the	the	DT
en-wikipedia-org-4107	1061	70	molecular	molecular	JJ
en-wikipedia-org-4107	1061	71	switch	switch	NN
en-wikipedia-org-4107	1061	72	whereby	whereby	WRB
en-wikipedia-org-4107	1061	73	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1061	74	is	be	VBZ
en-wikipedia-org-4107	1061	75	selectively	selectively	RB
en-wikipedia-org-4107	1061	76	induced	induce	VBN
en-wikipedia-org-4107	1061	77	in	in	IN
en-wikipedia-org-4107	1061	78	the	the	DT
en-wikipedia-org-4107	1061	79	chronic	chronic	JJ
en-wikipedia-org-4107	1061	80	drug	drug	NN
en-wikipedia-org-4107	1061	81	-	-	HYPH
en-wikipedia-org-4107	1061	82	treated	treat	VBN
en-wikipedia-org-4107	1061	83	state.41	state.41	NNP
en-wikipedia-org-4107	1061	84	.	.	.
en-wikipedia-org-4107	1062	1	...	...	NFP
en-wikipedia-org-4107	1063	1	Moreover	moreover	RB
en-wikipedia-org-4107	1063	2	,	,	,
en-wikipedia-org-4107	1063	3	there	there	EX
en-wikipedia-org-4107	1063	4	is	be	VBZ
en-wikipedia-org-4107	1063	5	increasing	increase	VBG
en-wikipedia-org-4107	1063	6	evidence	evidence	NN
en-wikipedia-org-4107	1063	7	that	that	IN
en-wikipedia-org-4107	1063	8	,	,	,
en-wikipedia-org-4107	1063	9	despite	despite	IN
en-wikipedia-org-4107	1063	10	a	a	DT
en-wikipedia-org-4107	1063	11	range	range	NN
en-wikipedia-org-4107	1063	12	of	of	IN
en-wikipedia-org-4107	1063	13	genetic	genetic	JJ
en-wikipedia-org-4107	1063	14	risks	risk	NNS
en-wikipedia-org-4107	1063	15	for	for	IN
en-wikipedia-org-4107	1063	16	addiction	addiction	NN
en-wikipedia-org-4107	1063	17	across	across	IN
en-wikipedia-org-4107	1063	18	the	the	DT
en-wikipedia-org-4107	1063	19	population	population	NN
en-wikipedia-org-4107	1063	20	,	,	,
en-wikipedia-org-4107	1063	21	exposure	exposure	NN
en-wikipedia-org-4107	1063	22	to	to	IN
en-wikipedia-org-4107	1063	23	sufficiently	sufficiently	RB
en-wikipedia-org-4107	1063	24	high	high	JJ
en-wikipedia-org-4107	1063	25	doses	dose	NNS
en-wikipedia-org-4107	1063	26	of	of	IN
en-wikipedia-org-4107	1063	27	a	a	DT
en-wikipedia-org-4107	1063	28	drug	drug	NN
en-wikipedia-org-4107	1063	29	for	for	IN
en-wikipedia-org-4107	1063	30	long	long	JJ
en-wikipedia-org-4107	1063	31	periods	period	NNS
en-wikipedia-org-4107	1063	32	of	of	IN
en-wikipedia-org-4107	1063	33	time	time	NN
en-wikipedia-org-4107	1063	34	can	can	MD
en-wikipedia-org-4107	1063	35	transform	transform	VB
en-wikipedia-org-4107	1063	36	someone	someone	NN
en-wikipedia-org-4107	1063	37	who	who	WP
en-wikipedia-org-4107	1063	38	has	have	VBZ
en-wikipedia-org-4107	1063	39	relatively	relatively	RB
en-wikipedia-org-4107	1063	40	lower	low	JJR
en-wikipedia-org-4107	1063	41	genetic	genetic	JJ
en-wikipedia-org-4107	1063	42	loading	loading	NN
en-wikipedia-org-4107	1063	43	into	into	IN
en-wikipedia-org-4107	1063	44	an	an	DT
en-wikipedia-org-4107	1063	45	addict	addict	NN
en-wikipedia-org-4107	1063	46	.	.	.
en-wikipedia-org-4107	1064	1	^	^	FW
en-wikipedia-org-4107	1064	2	"	"	``
en-wikipedia-org-4107	1064	3	Glossary	Glossary	NNP
en-wikipedia-org-4107	1064	4	of	of	IN
en-wikipedia-org-4107	1064	5	Terms	Terms	NNPS
en-wikipedia-org-4107	1064	6	"	"	''
en-wikipedia-org-4107	1064	7	.	.	.
en-wikipedia-org-4107	1065	1	Mount	Mount	NNP
en-wikipedia-org-4107	1065	2	Sinai	Sinai	NNP
en-wikipedia-org-4107	1065	3	School	School	NNP
en-wikipedia-org-4107	1065	4	of	of	IN
en-wikipedia-org-4107	1065	5	Medicine	Medicine	NNP
en-wikipedia-org-4107	1065	6	.	.	.
en-wikipedia-org-4107	1066	1	Department	Department	NNP
en-wikipedia-org-4107	1066	2	of	of	IN
en-wikipedia-org-4107	1066	3	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1066	4	.	.	.
en-wikipedia-org-4107	1067	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1067	2	9	9	CD
en-wikipedia-org-4107	1067	3	February	February	NNP
en-wikipedia-org-4107	1067	4	2015	2015	CD
en-wikipedia-org-4107	1067	5	.	.	.
en-wikipedia-org-4107	1068	1	^	^	NNP
en-wikipedia-org-4107	1068	2	Volkow	Volkow	NNP
en-wikipedia-org-4107	1068	3	ND	ND	NNP
en-wikipedia-org-4107	1068	4	,	,	,
en-wikipedia-org-4107	1068	5	Koob	Koob	NNP
en-wikipedia-org-4107	1068	6	GF	GF	NNP
en-wikipedia-org-4107	1068	7	,	,	,
en-wikipedia-org-4107	1068	8	McLellan	McLellan	NNP
en-wikipedia-org-4107	1068	9	AT	AT	NNP
en-wikipedia-org-4107	1068	10	(	(	-LRB-
en-wikipedia-org-4107	1068	11	January	January	NNP
en-wikipedia-org-4107	1068	12	2016	2016	CD
en-wikipedia-org-4107	1068	13	)	)	-RRB-
en-wikipedia-org-4107	1068	14	.	.	.
en-wikipedia-org-4107	1069	1	"	"	``
en-wikipedia-org-4107	1069	2	Neurobiologic	Neurobiologic	NNP
en-wikipedia-org-4107	1069	3	Advances	Advances	NNPS
en-wikipedia-org-4107	1069	4	from	from	IN
en-wikipedia-org-4107	1069	5	the	the	DT
en-wikipedia-org-4107	1069	6	Brain	Brain	NNP
en-wikipedia-org-4107	1069	7	Disease	Disease	NNP
en-wikipedia-org-4107	1069	8	Model	Model	NNP
en-wikipedia-org-4107	1069	9	of	of	IN
en-wikipedia-org-4107	1069	10	Addiction	Addiction	NNP
en-wikipedia-org-4107	1069	11	"	"	''
en-wikipedia-org-4107	1069	12	.	.	.
en-wikipedia-org-4107	1070	1	New	New	NNP
en-wikipedia-org-4107	1070	2	England	England	NNP
en-wikipedia-org-4107	1070	3	Journal	Journal	NNP
en-wikipedia-org-4107	1070	4	of	of	IN
en-wikipedia-org-4107	1070	5	Medicine	Medicine	NNP
en-wikipedia-org-4107	1070	6	.	.	.
en-wikipedia-org-4107	1071	1	374	374	CD
en-wikipedia-org-4107	1071	2	(	(	-LRB-
en-wikipedia-org-4107	1071	3	4	4	CD
en-wikipedia-org-4107	1071	4	)	)	-RRB-
en-wikipedia-org-4107	1071	5	:	:	:
en-wikipedia-org-4107	1071	6	363–371	363–371	CD
en-wikipedia-org-4107	1071	7	.	.	.
en-wikipedia-org-4107	1072	1	doi:10.1056	doi:10.1056	NNP
en-wikipedia-org-4107	1072	2	/	/	SYM
en-wikipedia-org-4107	1072	3	NEJMra1511480	nejmra1511480	UH
en-wikipedia-org-4107	1072	4	.	.	.
en-wikipedia-org-4107	1073	1	PMC	PMC	NNP
en-wikipedia-org-4107	1073	2	 	  	_SP
en-wikipedia-org-4107	1073	3	6135257	6135257	CD
en-wikipedia-org-4107	1073	4	.	.	.
en-wikipedia-org-4107	1074	1	PMID	PMID	NNP
en-wikipedia-org-4107	1074	2	 	  	_SP
en-wikipedia-org-4107	1074	3	26816013	26816013	CD
en-wikipedia-org-4107	1074	4	.	.	.
en-wikipedia-org-4107	1075	1	Substance	substance	NN
en-wikipedia-org-4107	1075	2	-	-	HYPH
en-wikipedia-org-4107	1075	3	use	use	NN
en-wikipedia-org-4107	1075	4	disorder	disorder	NN
en-wikipedia-org-4107	1075	5	:	:	:
en-wikipedia-org-4107	1075	6	A	a	DT
en-wikipedia-org-4107	1075	7	diagnostic	diagnostic	JJ
en-wikipedia-org-4107	1075	8	term	term	NN
en-wikipedia-org-4107	1075	9	in	in	IN
en-wikipedia-org-4107	1075	10	the	the	DT
en-wikipedia-org-4107	1075	11	fifth	fifth	JJ
en-wikipedia-org-4107	1075	12	edition	edition	NN
en-wikipedia-org-4107	1075	13	of	of	IN
en-wikipedia-org-4107	1075	14	the	the	DT
en-wikipedia-org-4107	1075	15	Diagnostic	Diagnostic	NNP
en-wikipedia-org-4107	1075	16	and	and	CC
en-wikipedia-org-4107	1075	17	Statistical	Statistical	NNP
en-wikipedia-org-4107	1075	18	Manual	Manual	NNP
en-wikipedia-org-4107	1075	19	of	of	IN
en-wikipedia-org-4107	1075	20	Mental	Mental	NNP
en-wikipedia-org-4107	1075	21	Disorders	Disorders	NNPS
en-wikipedia-org-4107	1075	22	(	(	-LRB-
en-wikipedia-org-4107	1075	23	DSM-5	DSM-5	NNP
en-wikipedia-org-4107	1075	24	)	)	-RRB-
en-wikipedia-org-4107	1075	25	referring	refer	VBG
en-wikipedia-org-4107	1075	26	to	to	IN
en-wikipedia-org-4107	1075	27	recurrent	recurrent	JJ
en-wikipedia-org-4107	1075	28	use	use	NN
en-wikipedia-org-4107	1075	29	of	of	IN
en-wikipedia-org-4107	1075	30	alcohol	alcohol	NN
en-wikipedia-org-4107	1075	31	or	or	CC
en-wikipedia-org-4107	1075	32	other	other	JJ
en-wikipedia-org-4107	1075	33	drugs	drug	NNS
en-wikipedia-org-4107	1075	34	that	that	WDT
en-wikipedia-org-4107	1075	35	causes	cause	VBZ
en-wikipedia-org-4107	1075	36	clinically	clinically	RB
en-wikipedia-org-4107	1075	37	and	and	CC
en-wikipedia-org-4107	1075	38	functionally	functionally	RB
en-wikipedia-org-4107	1075	39	significant	significant	JJ
en-wikipedia-org-4107	1075	40	impairment	impairment	NN
en-wikipedia-org-4107	1075	41	,	,	,
en-wikipedia-org-4107	1075	42	such	such	JJ
en-wikipedia-org-4107	1075	43	as	as	IN
en-wikipedia-org-4107	1075	44	health	health	NN
en-wikipedia-org-4107	1075	45	problems	problem	NNS
en-wikipedia-org-4107	1075	46	,	,	,
en-wikipedia-org-4107	1075	47	disability	disability	NN
en-wikipedia-org-4107	1075	48	,	,	,
en-wikipedia-org-4107	1075	49	and	and	CC
en-wikipedia-org-4107	1075	50	failure	failure	NN
en-wikipedia-org-4107	1075	51	to	to	TO
en-wikipedia-org-4107	1075	52	meet	meet	VB
en-wikipedia-org-4107	1075	53	major	major	JJ
en-wikipedia-org-4107	1075	54	responsibilities	responsibility	NNS
en-wikipedia-org-4107	1075	55	at	at	IN
en-wikipedia-org-4107	1075	56	work	work	NN
en-wikipedia-org-4107	1075	57	,	,	,
en-wikipedia-org-4107	1075	58	school	school	NN
en-wikipedia-org-4107	1075	59	,	,	,
en-wikipedia-org-4107	1075	60	or	or	CC
en-wikipedia-org-4107	1075	61	home	home	NN
en-wikipedia-org-4107	1075	62	.	.	.
en-wikipedia-org-4107	1076	1	Depending	depend	VBG
en-wikipedia-org-4107	1076	2	on	on	IN
en-wikipedia-org-4107	1076	3	the	the	DT
en-wikipedia-org-4107	1076	4	level	level	NN
en-wikipedia-org-4107	1076	5	of	of	IN
en-wikipedia-org-4107	1076	6	severity	severity	NN
en-wikipedia-org-4107	1076	7	,	,	,
en-wikipedia-org-4107	1076	8	this	this	DT
en-wikipedia-org-4107	1076	9	disorder	disorder	NN
en-wikipedia-org-4107	1076	10	is	be	VBZ
en-wikipedia-org-4107	1076	11	classified	classify	VBN
en-wikipedia-org-4107	1076	12	as	as	IN
en-wikipedia-org-4107	1076	13	mild	mild	JJ
en-wikipedia-org-4107	1076	14	,	,	,
en-wikipedia-org-4107	1076	15	moderate	moderate	JJ
en-wikipedia-org-4107	1076	16	,	,	,
en-wikipedia-org-4107	1076	17	or	or	CC
en-wikipedia-org-4107	1076	18	severe	severe	JJ
en-wikipedia-org-4107	1076	19	.	.	.
en-wikipedia-org-4107	1077	1	Addiction	addiction	NN
en-wikipedia-org-4107	1077	2	:	:	:
en-wikipedia-org-4107	1077	3	A	a	DT
en-wikipedia-org-4107	1077	4	term	term	NN
en-wikipedia-org-4107	1077	5	used	use	VBN
en-wikipedia-org-4107	1077	6	to	to	TO
en-wikipedia-org-4107	1077	7	indicate	indicate	VB
en-wikipedia-org-4107	1077	8	the	the	DT
en-wikipedia-org-4107	1077	9	most	most	RBS
en-wikipedia-org-4107	1077	10	severe	severe	JJ
en-wikipedia-org-4107	1077	11	,	,	,
en-wikipedia-org-4107	1077	12	chronic	chronic	JJ
en-wikipedia-org-4107	1077	13	stage	stage	NN
en-wikipedia-org-4107	1077	14	of	of	IN
en-wikipedia-org-4107	1077	15	substance	substance	NN
en-wikipedia-org-4107	1077	16	-	-	HYPH
en-wikipedia-org-4107	1077	17	use	use	NN
en-wikipedia-org-4107	1077	18	disorder	disorder	NN
en-wikipedia-org-4107	1077	19	,	,	,
en-wikipedia-org-4107	1077	20	in	in	IN
en-wikipedia-org-4107	1077	21	which	which	WDT
en-wikipedia-org-4107	1077	22	there	there	EX
en-wikipedia-org-4107	1077	23	is	be	VBZ
en-wikipedia-org-4107	1077	24	a	a	DT
en-wikipedia-org-4107	1077	25	substantial	substantial	JJ
en-wikipedia-org-4107	1077	26	loss	loss	NN
en-wikipedia-org-4107	1077	27	of	of	IN
en-wikipedia-org-4107	1077	28	self	self	NN
en-wikipedia-org-4107	1077	29	-	-	HYPH
en-wikipedia-org-4107	1077	30	control	control	NN
en-wikipedia-org-4107	1077	31	,	,	,
en-wikipedia-org-4107	1077	32	as	as	IN
en-wikipedia-org-4107	1077	33	indicated	indicate	VBN
en-wikipedia-org-4107	1077	34	by	by	IN
en-wikipedia-org-4107	1077	35	compulsive	compulsive	JJ
en-wikipedia-org-4107	1077	36	drug	drug	NN
en-wikipedia-org-4107	1077	37	taking	take	VBG
en-wikipedia-org-4107	1077	38	despite	despite	IN
en-wikipedia-org-4107	1077	39	the	the	DT
en-wikipedia-org-4107	1077	40	desire	desire	NN
en-wikipedia-org-4107	1077	41	to	to	TO
en-wikipedia-org-4107	1077	42	stop	stop	VB
en-wikipedia-org-4107	1077	43	taking	take	VBG
en-wikipedia-org-4107	1077	44	the	the	DT
en-wikipedia-org-4107	1077	45	drug	drug	NN
en-wikipedia-org-4107	1077	46	.	.	.
en-wikipedia-org-4107	1078	1	In	in	IN
en-wikipedia-org-4107	1078	2	the	the	DT
en-wikipedia-org-4107	1078	3	DSM-5	DSM-5	NNP
en-wikipedia-org-4107	1078	4	,	,	,
en-wikipedia-org-4107	1078	5	the	the	DT
en-wikipedia-org-4107	1078	6	term	term	NN
en-wikipedia-org-4107	1078	7	addiction	addiction	NN
en-wikipedia-org-4107	1078	8	is	be	VBZ
en-wikipedia-org-4107	1078	9	synonymous	synonymous	JJ
en-wikipedia-org-4107	1078	10	with	with	IN
en-wikipedia-org-4107	1078	11	the	the	DT
en-wikipedia-org-4107	1078	12	classification	classification	NN
en-wikipedia-org-4107	1078	13	of	of	IN
en-wikipedia-org-4107	1078	14	severe	severe	JJ
en-wikipedia-org-4107	1078	15	substance	substance	NN
en-wikipedia-org-4107	1078	16	-	-	HYPH
en-wikipedia-org-4107	1078	17	use	use	NN
en-wikipedia-org-4107	1078	18	disorder	disorder	NN
en-wikipedia-org-4107	1078	19	.	.	.
en-wikipedia-org-4107	1079	1	^	^	NNP
en-wikipedia-org-4107	1079	2	a	a	DT
en-wikipedia-org-4107	1079	3	b	b	NN
en-wikipedia-org-4107	1079	4	c	c	NN
en-wikipedia-org-4107	1079	5	Renthal	Renthal	NNP
en-wikipedia-org-4107	1079	6	W	W	NNP
en-wikipedia-org-4107	1079	7	,	,	,
en-wikipedia-org-4107	1079	8	Nestler	Nestler	NNP
en-wikipedia-org-4107	1079	9	EJ	EJ	NNP
en-wikipedia-org-4107	1079	10	(	(	-LRB-
en-wikipedia-org-4107	1079	11	September	September	NNP
en-wikipedia-org-4107	1079	12	2009	2009	CD
en-wikipedia-org-4107	1079	13	)	)	-RRB-
en-wikipedia-org-4107	1079	14	.	.	.
en-wikipedia-org-4107	1080	1	"	"	``
en-wikipedia-org-4107	1080	2	Chromatin	Chromatin	NNP
en-wikipedia-org-4107	1080	3	regulation	regulation	NN
en-wikipedia-org-4107	1080	4	in	in	IN
en-wikipedia-org-4107	1080	5	drug	drug	NN
en-wikipedia-org-4107	1080	6	addiction	addiction	NN
en-wikipedia-org-4107	1080	7	and	and	CC
en-wikipedia-org-4107	1080	8	depression	depression	NN
en-wikipedia-org-4107	1080	9	"	"	''
en-wikipedia-org-4107	1080	10	.	.	.
en-wikipedia-org-4107	1081	1	Dialogues	dialogue	NNS
en-wikipedia-org-4107	1081	2	in	in	IN
en-wikipedia-org-4107	1081	3	Clinical	Clinical	NNP
en-wikipedia-org-4107	1081	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1081	5	.	.	.
en-wikipedia-org-4107	1082	1	11	11	CD
en-wikipedia-org-4107	1082	2	(	(	-LRB-
en-wikipedia-org-4107	1082	3	3	3	CD
en-wikipedia-org-4107	1082	4	)	)	-RRB-
en-wikipedia-org-4107	1082	5	:	:	:
en-wikipedia-org-4107	1082	6	257–268	257–268	CD
en-wikipedia-org-4107	1082	7	.	.	.
en-wikipedia-org-4107	1083	1	PMC	PMC	NNP
en-wikipedia-org-4107	1083	2	 	  	_SP
en-wikipedia-org-4107	1083	3	2834246	2834246	CD
en-wikipedia-org-4107	1083	4	.	.	.
en-wikipedia-org-4107	1084	1	PMID	PMID	NNP
en-wikipedia-org-4107	1084	2	 	  	_SP
en-wikipedia-org-4107	1084	3	19877494	19877494	CD
en-wikipedia-org-4107	1084	4	.	.	.
en-wikipedia-org-4107	1085	1	[	[	-LRB-
en-wikipedia-org-4107	1085	2	Psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	1085	3	]	]	-RRB-
en-wikipedia-org-4107	1085	4	increase	increase	VBP
en-wikipedia-org-4107	1085	5	cAMP	camp	NN
en-wikipedia-org-4107	1085	6	levels	level	NNS
en-wikipedia-org-4107	1085	7	in	in	IN
en-wikipedia-org-4107	1085	8	striatum	striatum	NN
en-wikipedia-org-4107	1085	9	,	,	,
en-wikipedia-org-4107	1085	10	which	which	WDT
en-wikipedia-org-4107	1085	11	activates	activate	VBZ
en-wikipedia-org-4107	1085	12	protein	protein	NN
en-wikipedia-org-4107	1085	13	kinase	kinase	VBD
en-wikipedia-org-4107	1085	14	A	a	DT
en-wikipedia-org-4107	1085	15	(	(	-LRB-
en-wikipedia-org-4107	1085	16	PKA	PKA	NNP
en-wikipedia-org-4107	1085	17	)	)	-RRB-
en-wikipedia-org-4107	1085	18	and	and	CC
en-wikipedia-org-4107	1085	19	leads	lead	VBZ
en-wikipedia-org-4107	1085	20	to	to	IN
en-wikipedia-org-4107	1085	21	phosphorylation	phosphorylation	NN
en-wikipedia-org-4107	1085	22	of	of	IN
en-wikipedia-org-4107	1085	23	its	-PRON-	PRP$
en-wikipedia-org-4107	1085	24	targets	target	NNS
en-wikipedia-org-4107	1085	25	.	.	.
en-wikipedia-org-4107	1086	1	This	this	DT
en-wikipedia-org-4107	1086	2	includes	include	VBZ
en-wikipedia-org-4107	1086	3	the	the	DT
en-wikipedia-org-4107	1086	4	cAMP	camp	NN
en-wikipedia-org-4107	1086	5	response	response	NN
en-wikipedia-org-4107	1086	6	element	element	NN
en-wikipedia-org-4107	1086	7	binding	bind	VBG
en-wikipedia-org-4107	1086	8	protein	protein	NN
en-wikipedia-org-4107	1086	9	(	(	-LRB-
en-wikipedia-org-4107	1086	10	CREB	CREB	NNP
en-wikipedia-org-4107	1086	11	)	)	-RRB-
en-wikipedia-org-4107	1086	12	,	,	,
en-wikipedia-org-4107	1086	13	the	the	DT
en-wikipedia-org-4107	1086	14	phosphorylation	phosphorylation	NN
en-wikipedia-org-4107	1086	15	of	of	IN
en-wikipedia-org-4107	1086	16	which	which	WDT
en-wikipedia-org-4107	1086	17	induces	induce	VBZ
en-wikipedia-org-4107	1086	18	its	-PRON-	PRP$
en-wikipedia-org-4107	1086	19	association	association	NN
en-wikipedia-org-4107	1086	20	with	with	IN
en-wikipedia-org-4107	1086	21	the	the	DT
en-wikipedia-org-4107	1086	22	histone	histone	JJ
en-wikipedia-org-4107	1086	23	acetyltransferase	acetyltransferase	NN
en-wikipedia-org-4107	1086	24	,	,	,
en-wikipedia-org-4107	1086	25	CREB	CREB	NNP
en-wikipedia-org-4107	1086	26	binding	bind	VBG
en-wikipedia-org-4107	1086	27	protein	protein	NN
en-wikipedia-org-4107	1086	28	(	(	-LRB-
en-wikipedia-org-4107	1086	29	CBP	CBP	NNP
en-wikipedia-org-4107	1086	30	)	)	-RRB-
en-wikipedia-org-4107	1086	31	to	to	TO
en-wikipedia-org-4107	1086	32	acetylate	acetylate	VB
en-wikipedia-org-4107	1086	33	histones	histone	NNS
en-wikipedia-org-4107	1086	34	and	and	CC
en-wikipedia-org-4107	1086	35	facilitate	facilitate	VB
en-wikipedia-org-4107	1086	36	gene	gene	NN
en-wikipedia-org-4107	1086	37	activation	activation	NN
en-wikipedia-org-4107	1086	38	.	.	.
en-wikipedia-org-4107	1087	1	This	this	DT
en-wikipedia-org-4107	1087	2	is	be	VBZ
en-wikipedia-org-4107	1087	3	known	know	VBN
en-wikipedia-org-4107	1087	4	to	to	TO
en-wikipedia-org-4107	1087	5	occur	occur	VB
en-wikipedia-org-4107	1087	6	on	on	IN
en-wikipedia-org-4107	1087	7	many	many	JJ
en-wikipedia-org-4107	1087	8	genes	gene	NNS
en-wikipedia-org-4107	1087	9	including	include	VBG
en-wikipedia-org-4107	1087	10	fosB	fosB	:
en-wikipedia-org-4107	1087	11	and	and	CC
en-wikipedia-org-4107	1087	12	c	c	NN
en-wikipedia-org-4107	1087	13	-	-	HYPH
en-wikipedia-org-4107	1087	14	fos	fos	NN
en-wikipedia-org-4107	1087	15	in	in	IN
en-wikipedia-org-4107	1087	16	response	response	NN
en-wikipedia-org-4107	1087	17	to	to	IN
en-wikipedia-org-4107	1087	18	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	1087	19	exposure	exposure	NN
en-wikipedia-org-4107	1087	20	.	.	.
en-wikipedia-org-4107	1088	1	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1088	2	is	be	VBZ
en-wikipedia-org-4107	1088	3	also	also	RB
en-wikipedia-org-4107	1088	4	upregulated	upregulate	VBN
en-wikipedia-org-4107	1088	5	by	by	IN
en-wikipedia-org-4107	1088	6	chronic	chronic	JJ
en-wikipedia-org-4107	1088	7	psychostimulant	psychostimulant	NN
en-wikipedia-org-4107	1088	8	treatments	treatment	NNS
en-wikipedia-org-4107	1088	9	,	,	,
en-wikipedia-org-4107	1088	10	and	and	CC
en-wikipedia-org-4107	1088	11	is	be	VBZ
en-wikipedia-org-4107	1088	12	known	know	VBN
en-wikipedia-org-4107	1088	13	to	to	TO
en-wikipedia-org-4107	1088	14	activate	activate	VB
en-wikipedia-org-4107	1088	15	certain	certain	JJ
en-wikipedia-org-4107	1088	16	genes	gene	NNS
en-wikipedia-org-4107	1088	17	(	(	-LRB-
en-wikipedia-org-4107	1088	18	eg	eg	NNP
en-wikipedia-org-4107	1088	19	,	,	,
en-wikipedia-org-4107	1088	20	cdk5	cdk5	NNP
en-wikipedia-org-4107	1088	21	)	)	-RRB-
en-wikipedia-org-4107	1088	22	and	and	CC
en-wikipedia-org-4107	1088	23	repress	repress	VB
en-wikipedia-org-4107	1088	24	others	other	NNS
en-wikipedia-org-4107	1088	25	(	(	-LRB-
en-wikipedia-org-4107	1088	26	eg	eg	NNP
en-wikipedia-org-4107	1088	27	,	,	,
en-wikipedia-org-4107	1088	28	c	c	NN
en-wikipedia-org-4107	1088	29	-	-	HYPH
en-wikipedia-org-4107	1088	30	fos	fos	NNP
en-wikipedia-org-4107	1088	31	)	)	-RRB-
en-wikipedia-org-4107	1088	32	where	where	WRB
en-wikipedia-org-4107	1088	33	it	-PRON-	PRP
en-wikipedia-org-4107	1088	34	recruits	recruit	VBZ
en-wikipedia-org-4107	1088	35	HDAC1	hdac1	UH
en-wikipedia-org-4107	1088	36	as	as	IN
en-wikipedia-org-4107	1088	37	a	a	DT
en-wikipedia-org-4107	1088	38	corepressor	corepressor	NN
en-wikipedia-org-4107	1088	39	.	.	.
en-wikipedia-org-4107	1089	1	...	...	NFP
en-wikipedia-org-4107	1090	1	Chronic	chronic	JJ
en-wikipedia-org-4107	1090	2	exposure	exposure	NN
en-wikipedia-org-4107	1090	3	to	to	IN
en-wikipedia-org-4107	1090	4	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	1090	5	increases	increase	VBZ
en-wikipedia-org-4107	1090	6	glutamatergic	glutamatergic	JJ
en-wikipedia-org-4107	1090	7	[	[	-LRB-
en-wikipedia-org-4107	1090	8	signaling	signal	VBG
en-wikipedia-org-4107	1090	9	]	]	-RRB-
en-wikipedia-org-4107	1090	10	from	from	IN
en-wikipedia-org-4107	1090	11	the	the	DT
en-wikipedia-org-4107	1090	12	prefrontal	prefrontal	JJ
en-wikipedia-org-4107	1090	13	cortex	cortex	NNP
en-wikipedia-org-4107	1090	14	to	to	IN
en-wikipedia-org-4107	1090	15	the	the	DT
en-wikipedia-org-4107	1090	16	NAc	NAc	NNS
en-wikipedia-org-4107	1090	17	.	.	.
en-wikipedia-org-4107	1091	1	Glutamatergic	glutamatergic	JJ
en-wikipedia-org-4107	1091	2	signaling	signal	VBG
en-wikipedia-org-4107	1091	3	elevates	elevate	NNS
en-wikipedia-org-4107	1091	4	Ca2	Ca2	NNS
en-wikipedia-org-4107	1091	5	+	+	CC
en-wikipedia-org-4107	1091	6	levels	level	NNS
en-wikipedia-org-4107	1091	7	in	in	IN
en-wikipedia-org-4107	1091	8	NAc	NAc	NNP
en-wikipedia-org-4107	1091	9	postsynaptic	postsynaptic	JJ
en-wikipedia-org-4107	1091	10	elements	element	NNS
en-wikipedia-org-4107	1091	11	where	where	WRB
en-wikipedia-org-4107	1091	12	it	-PRON-	PRP
en-wikipedia-org-4107	1091	13	activates	activate	VBZ
en-wikipedia-org-4107	1091	14	CaMK	CaMK	NNP
en-wikipedia-org-4107	1091	15	(	(	-LRB-
en-wikipedia-org-4107	1091	16	calcium	calcium	NNP
en-wikipedia-org-4107	1091	17	/	/	SYM
en-wikipedia-org-4107	1091	18	calmodulin	calmodulin	NNP
en-wikipedia-org-4107	1091	19	protein	protein	NN
en-wikipedia-org-4107	1091	20	kinases	kinases	NNP
en-wikipedia-org-4107	1091	21	)	)	-RRB-
en-wikipedia-org-4107	1091	22	signaling	signal	VBG
en-wikipedia-org-4107	1091	23	,	,	,
en-wikipedia-org-4107	1091	24	which	which	WDT
en-wikipedia-org-4107	1091	25	,	,	,
en-wikipedia-org-4107	1091	26	in	in	IN
en-wikipedia-org-4107	1091	27	addition	addition	NN
en-wikipedia-org-4107	1091	28	to	to	IN
en-wikipedia-org-4107	1091	29	phosphorylating	phosphorylate	VBG
en-wikipedia-org-4107	1091	30	CREB	CREB	NNP
en-wikipedia-org-4107	1091	31	,	,	,
en-wikipedia-org-4107	1091	32	also	also	RB
en-wikipedia-org-4107	1091	33	phosphorylates	phosphorylate	VBZ
en-wikipedia-org-4107	1091	34	HDAC5	hdac5	NN
en-wikipedia-org-4107	1091	35	.	.	.
en-wikipedia-org-4107	1092	1	Figure	figure	NN
en-wikipedia-org-4107	1092	2	2	2	CD
en-wikipedia-org-4107	1092	3	:	:	:
en-wikipedia-org-4107	1092	4	Psychostimulant	psychostimulant	NN
en-wikipedia-org-4107	1092	5	-	-	HYPH
en-wikipedia-org-4107	1092	6	induced	induce	VBN
en-wikipedia-org-4107	1092	7	signaling	signaling	NN
en-wikipedia-org-4107	1092	8	events	event	NNS
en-wikipedia-org-4107	1092	9	^	^	.
en-wikipedia-org-4107	1092	10	Broussard	Broussard	NNP
en-wikipedia-org-4107	1092	11	JI	JI	NNP
en-wikipedia-org-4107	1092	12	(	(	-LRB-
en-wikipedia-org-4107	1092	13	January	January	NNP
en-wikipedia-org-4107	1092	14	2012	2012	CD
en-wikipedia-org-4107	1092	15	)	)	-RRB-
en-wikipedia-org-4107	1092	16	.	.	.
en-wikipedia-org-4107	1093	1	"	"	``
en-wikipedia-org-4107	1093	2	Co	co	NN
en-wikipedia-org-4107	1093	3	-	-	NN
en-wikipedia-org-4107	1093	4	transmission	transmission	NN
en-wikipedia-org-4107	1093	5	of	of	IN
en-wikipedia-org-4107	1093	6	dopamine	dopamine	NN
en-wikipedia-org-4107	1093	7	and	and	CC
en-wikipedia-org-4107	1093	8	glutamate	glutamate	NN
en-wikipedia-org-4107	1093	9	"	"	''
en-wikipedia-org-4107	1093	10	.	.	.
en-wikipedia-org-4107	1094	1	The	the	DT
en-wikipedia-org-4107	1094	2	Journal	Journal	NNP
en-wikipedia-org-4107	1094	3	of	of	IN
en-wikipedia-org-4107	1094	4	General	General	NNP
en-wikipedia-org-4107	1094	5	Physiology	Physiology	NNP
en-wikipedia-org-4107	1094	6	.	.	.
en-wikipedia-org-4107	1095	1	139	139	CD
en-wikipedia-org-4107	1095	2	(	(	-LRB-
en-wikipedia-org-4107	1095	3	1	1	CD
en-wikipedia-org-4107	1095	4	)	)	-RRB-
en-wikipedia-org-4107	1095	5	:	:	:
en-wikipedia-org-4107	1095	6	93–96	93–96	CD
en-wikipedia-org-4107	1095	7	.	.	.
en-wikipedia-org-4107	1096	1	doi:10.1085	doi:10.1085	NNP
en-wikipedia-org-4107	1096	2	/	/	SYM
en-wikipedia-org-4107	1096	3	jgp.201110659	jgp.201110659	NNP
en-wikipedia-org-4107	1096	4	.	.	.
en-wikipedia-org-4107	1097	1	PMC	PMC	NNP
en-wikipedia-org-4107	1097	2	 	  	_SP
en-wikipedia-org-4107	1097	3	3250102	3250102	CD
en-wikipedia-org-4107	1097	4	.	.	.
en-wikipedia-org-4107	1098	1	PMID	PMID	NNP
en-wikipedia-org-4107	1098	2	 	  	_SP
en-wikipedia-org-4107	1098	3	22200950	22200950	CD
en-wikipedia-org-4107	1098	4	.	.	.
en-wikipedia-org-4107	1099	1	Coincident	coincident	NN
en-wikipedia-org-4107	1099	2	and	and	CC
en-wikipedia-org-4107	1099	3	convergent	convergent	NN
en-wikipedia-org-4107	1099	4	input	input	NN
en-wikipedia-org-4107	1099	5	often	often	RB
en-wikipedia-org-4107	1099	6	induces	induce	VBZ
en-wikipedia-org-4107	1099	7	plasticity	plasticity	NN
en-wikipedia-org-4107	1099	8	on	on	IN
en-wikipedia-org-4107	1099	9	a	a	DT
en-wikipedia-org-4107	1099	10	postsynaptic	postsynaptic	JJ
en-wikipedia-org-4107	1099	11	neuron	neuron	NN
en-wikipedia-org-4107	1099	12	.	.	.
en-wikipedia-org-4107	1100	1	The	the	DT
en-wikipedia-org-4107	1100	2	NAc	NAc	NNS
en-wikipedia-org-4107	1100	3	integrates	integrate	VBZ
en-wikipedia-org-4107	1100	4	processed	process	VBN
en-wikipedia-org-4107	1100	5	information	information	NN
en-wikipedia-org-4107	1100	6	about	about	IN
en-wikipedia-org-4107	1100	7	the	the	DT
en-wikipedia-org-4107	1100	8	environment	environment	NN
en-wikipedia-org-4107	1100	9	from	from	IN
en-wikipedia-org-4107	1100	10	basolateral	basolateral	NNP
en-wikipedia-org-4107	1100	11	amygdala	amygdala	NNP
en-wikipedia-org-4107	1100	12	,	,	,
en-wikipedia-org-4107	1100	13	hippocampus	hippocampus	NNP
en-wikipedia-org-4107	1100	14	,	,	,
en-wikipedia-org-4107	1100	15	and	and	CC
en-wikipedia-org-4107	1100	16	prefrontal	prefrontal	JJ
en-wikipedia-org-4107	1100	17	cortex	cortex	NNP
en-wikipedia-org-4107	1100	18	(	(	-LRB-
en-wikipedia-org-4107	1100	19	PFC	PFC	NNP
en-wikipedia-org-4107	1100	20	)	)	-RRB-
en-wikipedia-org-4107	1100	21	,	,	,
en-wikipedia-org-4107	1100	22	as	as	RB
en-wikipedia-org-4107	1100	23	well	well	RB
en-wikipedia-org-4107	1100	24	as	as	IN
en-wikipedia-org-4107	1100	25	projections	projection	NNS
en-wikipedia-org-4107	1100	26	from	from	IN
en-wikipedia-org-4107	1100	27	midbrain	midbrain	NN
en-wikipedia-org-4107	1100	28	dopamine	dopamine	NN
en-wikipedia-org-4107	1100	29	neurons	neuron	NNS
en-wikipedia-org-4107	1100	30	.	.	.
en-wikipedia-org-4107	1101	1	Previous	previous	JJ
en-wikipedia-org-4107	1101	2	studies	study	NNS
en-wikipedia-org-4107	1101	3	have	have	VBP
en-wikipedia-org-4107	1101	4	demonstrated	demonstrate	VBN
en-wikipedia-org-4107	1101	5	how	how	WRB
en-wikipedia-org-4107	1101	6	dopamine	dopamine	NN
en-wikipedia-org-4107	1101	7	modulates	modulate	VBZ
en-wikipedia-org-4107	1101	8	this	this	DT
en-wikipedia-org-4107	1101	9	integrative	integrative	JJ
en-wikipedia-org-4107	1101	10	process	process	NN
en-wikipedia-org-4107	1101	11	.	.	.
en-wikipedia-org-4107	1102	1	For	for	IN
en-wikipedia-org-4107	1102	2	example	example	NN
en-wikipedia-org-4107	1102	3	,	,	,
en-wikipedia-org-4107	1102	4	high	high	JJ
en-wikipedia-org-4107	1102	5	frequency	frequency	NN
en-wikipedia-org-4107	1102	6	stimulation	stimulation	NN
en-wikipedia-org-4107	1102	7	potentiates	potentiate	VBZ
en-wikipedia-org-4107	1102	8	hippocampal	hippocampal	NNP
en-wikipedia-org-4107	1102	9	inputs	input	NNS
en-wikipedia-org-4107	1102	10	to	to	IN
en-wikipedia-org-4107	1102	11	the	the	DT
en-wikipedia-org-4107	1102	12	NAc	NAc	NNS
en-wikipedia-org-4107	1102	13	while	while	IN
en-wikipedia-org-4107	1102	14	simultaneously	simultaneously	RB
en-wikipedia-org-4107	1102	15	depressing	depress	VBG
en-wikipedia-org-4107	1102	16	PFC	PFC	NNP
en-wikipedia-org-4107	1102	17	synapses	synapse	VBZ
en-wikipedia-org-4107	1102	18	(	(	-LRB-
en-wikipedia-org-4107	1102	19	Goto	Goto	NNP
en-wikipedia-org-4107	1102	20	and	and	CC
en-wikipedia-org-4107	1102	21	Grace	Grace	NNP
en-wikipedia-org-4107	1102	22	,	,	,
en-wikipedia-org-4107	1102	23	2005	2005	CD
en-wikipedia-org-4107	1102	24	)	)	-RRB-
en-wikipedia-org-4107	1102	25	.	.	.
en-wikipedia-org-4107	1103	1	The	the	DT
en-wikipedia-org-4107	1103	2	converse	converse	NN
en-wikipedia-org-4107	1103	3	was	be	VBD
en-wikipedia-org-4107	1103	4	also	also	RB
en-wikipedia-org-4107	1103	5	shown	show	VBN
en-wikipedia-org-4107	1103	6	to	to	TO
en-wikipedia-org-4107	1103	7	be	be	VB
en-wikipedia-org-4107	1103	8	true	true	JJ
en-wikipedia-org-4107	1103	9	;	;	:
en-wikipedia-org-4107	1103	10	stimulation	stimulation	NN
en-wikipedia-org-4107	1103	11	at	at	IN
en-wikipedia-org-4107	1103	12	PFC	PFC	NNP
en-wikipedia-org-4107	1103	13	potentiates	potentiates	NNP
en-wikipedia-org-4107	1103	14	PFC	PFC	NNP
en-wikipedia-org-4107	1103	15	–	–	:
en-wikipedia-org-4107	1103	16	NAc	NAc	NNP
en-wikipedia-org-4107	1103	17	synapses	synapse	VBZ
en-wikipedia-org-4107	1103	18	but	but	CC
en-wikipedia-org-4107	1103	19	depresses	depresses	NNP
en-wikipedia-org-4107	1103	20	hippocampal	hippocampal	NNP
en-wikipedia-org-4107	1103	21	–	–	:
en-wikipedia-org-4107	1103	22	NAc	NAc	NNP
en-wikipedia-org-4107	1103	23	synapses	synapse	VBZ
en-wikipedia-org-4107	1103	24	.	.	.
en-wikipedia-org-4107	1104	1	In	in	IN
en-wikipedia-org-4107	1104	2	light	light	NN
en-wikipedia-org-4107	1104	3	of	of	IN
en-wikipedia-org-4107	1104	4	the	the	DT
en-wikipedia-org-4107	1104	5	new	new	JJ
en-wikipedia-org-4107	1104	6	functional	functional	JJ
en-wikipedia-org-4107	1104	7	evidence	evidence	NN
en-wikipedia-org-4107	1104	8	of	of	IN
en-wikipedia-org-4107	1104	9	midbrain	midbrain	NN
en-wikipedia-org-4107	1104	10	dopamine	dopamine	NN
en-wikipedia-org-4107	1104	11	/	/	SYM
en-wikipedia-org-4107	1104	12	glutamate	glutamate	JJ
en-wikipedia-org-4107	1104	13	co	co	NN
en-wikipedia-org-4107	1104	14	-	-	NN
en-wikipedia-org-4107	1104	15	transmission	transmission	NN
en-wikipedia-org-4107	1104	16	(	(	-LRB-
en-wikipedia-org-4107	1104	17	references	reference	NNS
en-wikipedia-org-4107	1104	18	above	above	IN
en-wikipedia-org-4107	1104	19	)	)	-RRB-
en-wikipedia-org-4107	1104	20	,	,	,
en-wikipedia-org-4107	1104	21	new	new	JJ
en-wikipedia-org-4107	1104	22	experiments	experiment	NNS
en-wikipedia-org-4107	1104	23	of	of	IN
en-wikipedia-org-4107	1104	24	NAc	NAc	NNS
en-wikipedia-org-4107	1104	25	function	function	NN
en-wikipedia-org-4107	1104	26	will	will	MD
en-wikipedia-org-4107	1104	27	have	have	VB
en-wikipedia-org-4107	1104	28	to	to	TO
en-wikipedia-org-4107	1104	29	test	test	VB
en-wikipedia-org-4107	1104	30	whether	whether	IN
en-wikipedia-org-4107	1104	31	midbrain	midbrain	NN
en-wikipedia-org-4107	1104	32	glutamatergic	glutamatergic	JJ
en-wikipedia-org-4107	1104	33	inputs	input	NNS
en-wikipedia-org-4107	1104	34	bias	bias	NN
en-wikipedia-org-4107	1104	35	or	or	CC
en-wikipedia-org-4107	1104	36	filter	filter	NN
en-wikipedia-org-4107	1104	37	either	either	CC
en-wikipedia-org-4107	1104	38	limbic	limbic	JJ
en-wikipedia-org-4107	1104	39	or	or	CC
en-wikipedia-org-4107	1104	40	cortical	cortical	JJ
en-wikipedia-org-4107	1104	41	inputs	input	NNS
en-wikipedia-org-4107	1104	42	to	to	TO
en-wikipedia-org-4107	1104	43	guide	guide	VB
en-wikipedia-org-4107	1104	44	goal	goal	NN
en-wikipedia-org-4107	1104	45	-	-	HYPH
en-wikipedia-org-4107	1104	46	directed	direct	VBN
en-wikipedia-org-4107	1104	47	behavior	behavior	NN
en-wikipedia-org-4107	1104	48	.	.	.
en-wikipedia-org-4107	1105	1	^	^	NNP
en-wikipedia-org-4107	1105	2	Kanehisa	Kanehisa	NNP
en-wikipedia-org-4107	1105	3	Laboratories	Laboratories	NNP
en-wikipedia-org-4107	1105	4	(	(	-LRB-
en-wikipedia-org-4107	1105	5	10	10	CD
en-wikipedia-org-4107	1105	6	October	October	NNP
en-wikipedia-org-4107	1105	7	2014	2014	CD
en-wikipedia-org-4107	1105	8	)	)	-RRB-
en-wikipedia-org-4107	1105	9	.	.	.
en-wikipedia-org-4107	1106	1	"	"	``
en-wikipedia-org-4107	1106	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1106	3	–	–	:
en-wikipedia-org-4107	1106	4	Homo	Homo	NNP
en-wikipedia-org-4107	1106	5	sapiens	sapiens	JJ
en-wikipedia-org-4107	1106	6	(	(	-LRB-
en-wikipedia-org-4107	1106	7	human	human	JJ
en-wikipedia-org-4107	1106	8	)	)	-RRB-
en-wikipedia-org-4107	1106	9	"	"	''
en-wikipedia-org-4107	1106	10	.	.	.
en-wikipedia-org-4107	1107	1	KEGG	KEGG	NNP
en-wikipedia-org-4107	1107	2	Pathway	Pathway	NNP
en-wikipedia-org-4107	1107	3	.	.	.
en-wikipedia-org-4107	1108	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1108	2	31	31	CD
en-wikipedia-org-4107	1108	3	October	October	NNP
en-wikipedia-org-4107	1108	4	2014	2014	CD
en-wikipedia-org-4107	1108	5	.	.	.
en-wikipedia-org-4107	1109	1	Most	Most	JJS
en-wikipedia-org-4107	1109	2	addictive	addictive	JJ
en-wikipedia-org-4107	1109	3	drugs	drug	NNS
en-wikipedia-org-4107	1109	4	increase	increase	VBP
en-wikipedia-org-4107	1109	5	extracellular	extracellular	JJ
en-wikipedia-org-4107	1109	6	concentrations	concentration	NNS
en-wikipedia-org-4107	1109	7	of	of	IN
en-wikipedia-org-4107	1109	8	dopamine	dopamine	NN
en-wikipedia-org-4107	1109	9	(	(	-LRB-
en-wikipedia-org-4107	1109	10	DA	DA	NNP
en-wikipedia-org-4107	1109	11	)	)	-RRB-
en-wikipedia-org-4107	1109	12	in	in	IN
en-wikipedia-org-4107	1109	13	nucleus	nucleus	NNP
en-wikipedia-org-4107	1109	14	accumbens	accumbens	NNPS
en-wikipedia-org-4107	1109	15	(	(	-LRB-
en-wikipedia-org-4107	1109	16	NAc	NAc	NNS
en-wikipedia-org-4107	1109	17	)	)	-RRB-
en-wikipedia-org-4107	1109	18	and	and	CC
en-wikipedia-org-4107	1109	19	medial	medial	NNP
en-wikipedia-org-4107	1109	20	prefrontal	prefrontal	NNP
en-wikipedia-org-4107	1109	21	cortex	cortex	NNP
en-wikipedia-org-4107	1109	22	(	(	-LRB-
en-wikipedia-org-4107	1109	23	mPFC	mPFC	NNP
en-wikipedia-org-4107	1109	24	)	)	-RRB-
en-wikipedia-org-4107	1109	25	,	,	,
en-wikipedia-org-4107	1109	26	projection	projection	NN
en-wikipedia-org-4107	1109	27	areas	area	NNS
en-wikipedia-org-4107	1109	28	of	of	IN
en-wikipedia-org-4107	1109	29	mesocorticolimbic	mesocorticolimbic	JJ
en-wikipedia-org-4107	1109	30	DA	DA	NNP
en-wikipedia-org-4107	1109	31	neurons	neuron	NNS
en-wikipedia-org-4107	1109	32	and	and	CC
en-wikipedia-org-4107	1109	33	key	key	JJ
en-wikipedia-org-4107	1109	34	components	component	NNS
en-wikipedia-org-4107	1109	35	of	of	IN
en-wikipedia-org-4107	1109	36	the	the	DT
en-wikipedia-org-4107	1109	37	"	"	``
en-wikipedia-org-4107	1109	38	brain	brain	NNP
en-wikipedia-org-4107	1109	39	reward	reward	NN
en-wikipedia-org-4107	1109	40	circuit	circuit	NNP
en-wikipedia-org-4107	1109	41	"	"	''
en-wikipedia-org-4107	1109	42	.	.	.
en-wikipedia-org-4107	1110	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1110	2	achieves	achieve	VBZ
en-wikipedia-org-4107	1110	3	this	this	DT
en-wikipedia-org-4107	1110	4	elevation	elevation	NN
en-wikipedia-org-4107	1110	5	in	in	IN
en-wikipedia-org-4107	1110	6	extracellular	extracellular	JJ
en-wikipedia-org-4107	1110	7	levels	level	NNS
en-wikipedia-org-4107	1110	8	of	of	IN
en-wikipedia-org-4107	1110	9	DA	DA	NNP
en-wikipedia-org-4107	1110	10	by	by	IN
en-wikipedia-org-4107	1110	11	promoting	promote	VBG
en-wikipedia-org-4107	1110	12	efflux	efflux	JJ
en-wikipedia-org-4107	1110	13	from	from	IN
en-wikipedia-org-4107	1110	14	synaptic	synaptic	JJ
en-wikipedia-org-4107	1110	15	terminals	terminal	NNS
en-wikipedia-org-4107	1110	16	.	.	.
en-wikipedia-org-4107	1111	1	...	...	NFP
en-wikipedia-org-4107	1112	1	Chronic	chronic	JJ
en-wikipedia-org-4107	1112	2	exposure	exposure	NN
en-wikipedia-org-4107	1112	3	to	to	TO
en-wikipedia-org-4107	1112	4	amphetamine	amphetamine	VB
en-wikipedia-org-4107	1112	5	induces	induce	VBZ
en-wikipedia-org-4107	1112	6	a	a	DT
en-wikipedia-org-4107	1112	7	unique	unique	JJ
en-wikipedia-org-4107	1112	8	transcription	transcription	NN
en-wikipedia-org-4107	1112	9	factor	factor	NN
en-wikipedia-org-4107	1112	10	delta	delta	NN
en-wikipedia-org-4107	1112	11	FosB	FosB	NNP
en-wikipedia-org-4107	1112	12	,	,	,
en-wikipedia-org-4107	1112	13	which	which	WDT
en-wikipedia-org-4107	1112	14	plays	play	VBZ
en-wikipedia-org-4107	1112	15	an	an	DT
en-wikipedia-org-4107	1112	16	essential	essential	JJ
en-wikipedia-org-4107	1112	17	role	role	NN
en-wikipedia-org-4107	1112	18	in	in	IN
en-wikipedia-org-4107	1112	19	long	long	JJ
en-wikipedia-org-4107	1112	20	-	-	HYPH
en-wikipedia-org-4107	1112	21	term	term	NN
en-wikipedia-org-4107	1112	22	adaptive	adaptive	JJ
en-wikipedia-org-4107	1112	23	changes	change	NNS
en-wikipedia-org-4107	1112	24	in	in	IN
en-wikipedia-org-4107	1112	25	the	the	DT
en-wikipedia-org-4107	1112	26	brain	brain	NN
en-wikipedia-org-4107	1112	27	.	.	.
en-wikipedia-org-4107	1113	1	^	^	NNP
en-wikipedia-org-4107	1113	2	a	a	DT
en-wikipedia-org-4107	1113	3	b	b	NNP
en-wikipedia-org-4107	1113	4	c	c	NN
en-wikipedia-org-4107	1113	5	Robison	Robison	NNP
en-wikipedia-org-4107	1113	6	AJ	AJ	NNP
en-wikipedia-org-4107	1113	7	,	,	,
en-wikipedia-org-4107	1113	8	Nestler	Nestler	NNP
en-wikipedia-org-4107	1113	9	EJ	EJ	NNP
en-wikipedia-org-4107	1113	10	(	(	-LRB-
en-wikipedia-org-4107	1113	11	November	November	NNP
en-wikipedia-org-4107	1113	12	2011	2011	CD
en-wikipedia-org-4107	1113	13	)	)	-RRB-
en-wikipedia-org-4107	1113	14	.	.	.
en-wikipedia-org-4107	1114	1	"	"	``
en-wikipedia-org-4107	1114	2	Transcriptional	transcriptional	JJ
en-wikipedia-org-4107	1114	3	and	and	CC
en-wikipedia-org-4107	1114	4	epigenetic	epigenetic	JJ
en-wikipedia-org-4107	1114	5	mechanisms	mechanism	NNS
en-wikipedia-org-4107	1114	6	of	of	IN
en-wikipedia-org-4107	1114	7	addiction	addiction	NN
en-wikipedia-org-4107	1114	8	"	"	''
en-wikipedia-org-4107	1114	9	.	.	.
en-wikipedia-org-4107	1115	1	Nature	Nature	NNP
en-wikipedia-org-4107	1115	2	Reviews	review	NNS
en-wikipedia-org-4107	1115	3	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1115	4	.	.	.
en-wikipedia-org-4107	1116	1	12	12	CD
en-wikipedia-org-4107	1116	2	(	(	-LRB-
en-wikipedia-org-4107	1116	3	11	11	CD
en-wikipedia-org-4107	1116	4	)	)	-RRB-
en-wikipedia-org-4107	1116	5	:	:	:
en-wikipedia-org-4107	1116	6	623–637	623–637	CD
en-wikipedia-org-4107	1116	7	.	.	.
en-wikipedia-org-4107	1117	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-4107	1117	2	/	/	SYM
en-wikipedia-org-4107	1117	3	nrn3111	nrn3111	NNP
en-wikipedia-org-4107	1117	4	.	.	.
en-wikipedia-org-4107	1118	1	PMC	PMC	NNP
en-wikipedia-org-4107	1118	2	 	  	_SP
en-wikipedia-org-4107	1118	3	3272277	3272277	CD
en-wikipedia-org-4107	1118	4	.	.	.
en-wikipedia-org-4107	1119	1	PMID	PMID	NNP
en-wikipedia-org-4107	1119	2	 	  	_SP
en-wikipedia-org-4107	1119	3	21989194	21989194	CD
en-wikipedia-org-4107	1119	4	.	.	.
en-wikipedia-org-4107	1120	1	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1120	2	serves	serve	VBZ
en-wikipedia-org-4107	1120	3	as	as	IN
en-wikipedia-org-4107	1120	4	one	one	CD
en-wikipedia-org-4107	1120	5	of	of	IN
en-wikipedia-org-4107	1120	6	the	the	DT
en-wikipedia-org-4107	1120	7	master	master	NN
en-wikipedia-org-4107	1120	8	control	control	NN
en-wikipedia-org-4107	1120	9	proteins	protein	NNS
en-wikipedia-org-4107	1120	10	governing	govern	VBG
en-wikipedia-org-4107	1120	11	this	this	DT
en-wikipedia-org-4107	1120	12	structural	structural	JJ
en-wikipedia-org-4107	1120	13	plasticity	plasticity	NN
en-wikipedia-org-4107	1120	14	.	.	.
en-wikipedia-org-4107	1121	1	...	...	NFP
en-wikipedia-org-4107	1121	2	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1121	3	also	also	RB
en-wikipedia-org-4107	1121	4	represses	repress	VBZ
en-wikipedia-org-4107	1121	5	G9a	G9a	NNP
en-wikipedia-org-4107	1121	6	expression	expression	NN
en-wikipedia-org-4107	1121	7	,	,	,
en-wikipedia-org-4107	1121	8	leading	lead	VBG
en-wikipedia-org-4107	1121	9	to	to	IN
en-wikipedia-org-4107	1121	10	reduced	reduce	VBN
en-wikipedia-org-4107	1121	11	repressive	repressive	JJ
en-wikipedia-org-4107	1121	12	histone	histone	NN
en-wikipedia-org-4107	1121	13	methylation	methylation	NN
en-wikipedia-org-4107	1121	14	at	at	IN
en-wikipedia-org-4107	1121	15	the	the	DT
en-wikipedia-org-4107	1121	16	cdk5	cdk5	NNP
en-wikipedia-org-4107	1121	17	gene	gene	NN
en-wikipedia-org-4107	1121	18	.	.	.
en-wikipedia-org-4107	1122	1	The	the	DT
en-wikipedia-org-4107	1122	2	net	net	JJ
en-wikipedia-org-4107	1122	3	result	result	NN
en-wikipedia-org-4107	1122	4	is	be	VBZ
en-wikipedia-org-4107	1122	5	gene	gene	NN
en-wikipedia-org-4107	1122	6	activation	activation	NN
en-wikipedia-org-4107	1122	7	and	and	CC
en-wikipedia-org-4107	1122	8	increased	increase	VBD
en-wikipedia-org-4107	1122	9	CDK5	CDK5	NNP
en-wikipedia-org-4107	1122	10	expression	expression	NN
en-wikipedia-org-4107	1122	11	.	.	.
en-wikipedia-org-4107	1123	1	...	...	NFP
en-wikipedia-org-4107	1124	1	In	in	IN
en-wikipedia-org-4107	1124	2	contrast	contrast	NN
en-wikipedia-org-4107	1124	3	,	,	,
en-wikipedia-org-4107	1124	4	ΔFosB	ΔFosB	VBZ
en-wikipedia-org-4107	1124	5	binds	bind	NNS
en-wikipedia-org-4107	1124	6	to	to	IN
en-wikipedia-org-4107	1124	7	the	the	DT
en-wikipedia-org-4107	1124	8	c	c	NN
en-wikipedia-org-4107	1124	9	-	-	HYPH
en-wikipedia-org-4107	1124	10	fos	fos	NN
en-wikipedia-org-4107	1124	11	gene	gene	NN
en-wikipedia-org-4107	1124	12	and	and	CC
en-wikipedia-org-4107	1124	13	recruits	recruit	VBZ
en-wikipedia-org-4107	1124	14	several	several	JJ
en-wikipedia-org-4107	1124	15	co	co	NNS
en-wikipedia-org-4107	1124	16	-	-	NNS
en-wikipedia-org-4107	1124	17	repressors	repressor	NNS
en-wikipedia-org-4107	1124	18	,	,	,
en-wikipedia-org-4107	1124	19	including	include	VBG
en-wikipedia-org-4107	1124	20	HDAC1	HDAC1	NNP
en-wikipedia-org-4107	1124	21	(	(	-LRB-
en-wikipedia-org-4107	1124	22	histone	histone	NNP
en-wikipedia-org-4107	1124	23	deacetylase	deacetylase	NN
en-wikipedia-org-4107	1124	24	1	1	CD
en-wikipedia-org-4107	1124	25	)	)	-RRB-
en-wikipedia-org-4107	1124	26	and	and	CC
en-wikipedia-org-4107	1124	27	SIRT	SIRT	NNP
en-wikipedia-org-4107	1124	28	1	1	CD
en-wikipedia-org-4107	1124	29	(	(	-LRB-
en-wikipedia-org-4107	1124	30	sirtuin	sirtuin	NN
en-wikipedia-org-4107	1124	31	1	1	CD
en-wikipedia-org-4107	1124	32	)	)	-RRB-
en-wikipedia-org-4107	1124	33	.	.	.
en-wikipedia-org-4107	1125	1	...	...	NFP
en-wikipedia-org-4107	1126	1	The	the	DT
en-wikipedia-org-4107	1126	2	net	net	JJ
en-wikipedia-org-4107	1126	3	result	result	NN
en-wikipedia-org-4107	1126	4	is	be	VBZ
en-wikipedia-org-4107	1126	5	c	c	NN
en-wikipedia-org-4107	1126	6	-	-	HYPH
en-wikipedia-org-4107	1126	7	fos	fos	NN
en-wikipedia-org-4107	1126	8	gene	gene	NN
en-wikipedia-org-4107	1126	9	repression	repression	NN
en-wikipedia-org-4107	1126	10	.	.	.
en-wikipedia-org-4107	1127	1	Figure	figure	NN
en-wikipedia-org-4107	1127	2	4	4	CD
en-wikipedia-org-4107	1127	3	:	:	:
en-wikipedia-org-4107	1127	4	Epigenetic	epigenetic	JJ
en-wikipedia-org-4107	1127	5	basis	basis	NN
en-wikipedia-org-4107	1127	6	of	of	IN
en-wikipedia-org-4107	1127	7	drug	drug	NN
en-wikipedia-org-4107	1127	8	regulation	regulation	NN
en-wikipedia-org-4107	1127	9	of	of	IN
en-wikipedia-org-4107	1127	10	gene	gene	NN
en-wikipedia-org-4107	1127	11	expression	expression	NN
en-wikipedia-org-4107	1127	12	^	^	.
en-wikipedia-org-4107	1127	13	a	a	DT
en-wikipedia-org-4107	1127	14	b	b	NNP
en-wikipedia-org-4107	1127	15	c	c	NNP
en-wikipedia-org-4107	1127	16	Nestler	Nestler	NNP
en-wikipedia-org-4107	1127	17	EJ	EJ	NNP
en-wikipedia-org-4107	1127	18	(	(	-LRB-
en-wikipedia-org-4107	1127	19	December	December	NNP
en-wikipedia-org-4107	1127	20	2012	2012	CD
en-wikipedia-org-4107	1127	21	)	)	-RRB-
en-wikipedia-org-4107	1127	22	.	.	.
en-wikipedia-org-4107	1128	1	"	"	``
en-wikipedia-org-4107	1128	2	Transcriptional	transcriptional	JJ
en-wikipedia-org-4107	1128	3	mechanisms	mechanism	NNS
en-wikipedia-org-4107	1128	4	of	of	IN
en-wikipedia-org-4107	1128	5	drug	drug	NN
en-wikipedia-org-4107	1128	6	addiction	addiction	NN
en-wikipedia-org-4107	1128	7	"	"	''
en-wikipedia-org-4107	1128	8	.	.	.
en-wikipedia-org-4107	1129	1	Clinical	Clinical	NNP
en-wikipedia-org-4107	1129	2	Psychopharmacology	Psychopharmacology	NNP
en-wikipedia-org-4107	1129	3	and	and	CC
en-wikipedia-org-4107	1129	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1129	5	.	.	.
en-wikipedia-org-4107	1130	1	10	10	CD
en-wikipedia-org-4107	1130	2	(	(	-LRB-
en-wikipedia-org-4107	1130	3	3	3	CD
en-wikipedia-org-4107	1130	4	)	)	-RRB-
en-wikipedia-org-4107	1130	5	:	:	:
en-wikipedia-org-4107	1130	6	136–143	136–143	CD
en-wikipedia-org-4107	1130	7	.	.	.
en-wikipedia-org-4107	1131	1	doi:10.9758	doi:10.9758	NNP
en-wikipedia-org-4107	1131	2	/	/	SYM
en-wikipedia-org-4107	1131	3	cpn.2012.10.3.136	cpn.2012.10.3.136	NNP
en-wikipedia-org-4107	1131	4	.	.	.
en-wikipedia-org-4107	1132	1	PMC	PMC	NNP
en-wikipedia-org-4107	1132	2	 	  	_SP
en-wikipedia-org-4107	1132	3	3569166	3569166	CD
en-wikipedia-org-4107	1132	4	.	.	.
en-wikipedia-org-4107	1133	1	PMID	PMID	NNP
en-wikipedia-org-4107	1133	2	 	  	_SP
en-wikipedia-org-4107	1133	3	23430970	23430970	CD
en-wikipedia-org-4107	1133	4	.	.	.
en-wikipedia-org-4107	1134	1	The	the	DT
en-wikipedia-org-4107	1134	2	35	35	CD
en-wikipedia-org-4107	1134	3	-	-	SYM
en-wikipedia-org-4107	1134	4	37	37	CD
en-wikipedia-org-4107	1134	5	kD	kD	NNP
en-wikipedia-org-4107	1134	6	ΔFosB	ΔFosB	VBN
en-wikipedia-org-4107	1134	7	isoforms	isoform	NNS
en-wikipedia-org-4107	1134	8	accumulate	accumulate	NN
en-wikipedia-org-4107	1134	9	with	with	IN
en-wikipedia-org-4107	1134	10	chronic	chronic	JJ
en-wikipedia-org-4107	1134	11	drug	drug	NN
en-wikipedia-org-4107	1134	12	exposure	exposure	NN
en-wikipedia-org-4107	1134	13	due	due	JJ
en-wikipedia-org-4107	1134	14	to	to	IN
en-wikipedia-org-4107	1134	15	their	-PRON-	PRP$
en-wikipedia-org-4107	1134	16	extraordinarily	extraordinarily	RB
en-wikipedia-org-4107	1134	17	long	long	JJ
en-wikipedia-org-4107	1134	18	half	half	NN
en-wikipedia-org-4107	1134	19	-	-	HYPH
en-wikipedia-org-4107	1134	20	lives	life	NNS
en-wikipedia-org-4107	1134	21	.	.	.
en-wikipedia-org-4107	1135	1	...	...	:
en-wikipedia-org-4107	1135	2	As	as	IN
en-wikipedia-org-4107	1135	3	a	a	DT
en-wikipedia-org-4107	1135	4	result	result	NN
en-wikipedia-org-4107	1135	5	of	of	IN
en-wikipedia-org-4107	1135	6	its	-PRON-	PRP$
en-wikipedia-org-4107	1135	7	stability	stability	NN
en-wikipedia-org-4107	1135	8	,	,	,
en-wikipedia-org-4107	1135	9	the	the	DT
en-wikipedia-org-4107	1135	10	ΔFosB	δfosb	JJ
en-wikipedia-org-4107	1135	11	protein	protein	NN
en-wikipedia-org-4107	1135	12	persists	persist	VBZ
en-wikipedia-org-4107	1135	13	in	in	IN
en-wikipedia-org-4107	1135	14	neurons	neuron	NNS
en-wikipedia-org-4107	1135	15	for	for	IN
en-wikipedia-org-4107	1135	16	at	at	RB
en-wikipedia-org-4107	1135	17	least	least	RBS
en-wikipedia-org-4107	1135	18	several	several	JJ
en-wikipedia-org-4107	1135	19	weeks	week	NNS
en-wikipedia-org-4107	1135	20	after	after	IN
en-wikipedia-org-4107	1135	21	cessation	cessation	NN
en-wikipedia-org-4107	1135	22	of	of	IN
en-wikipedia-org-4107	1135	23	drug	drug	NN
en-wikipedia-org-4107	1135	24	exposure	exposure	NN
en-wikipedia-org-4107	1135	25	.	.	.
en-wikipedia-org-4107	1136	1	...	...	NFP
en-wikipedia-org-4107	1136	2	ΔFosB	ΔFosB	VBN
en-wikipedia-org-4107	1136	3	overexpression	overexpression	NN
en-wikipedia-org-4107	1136	4	in	in	IN
en-wikipedia-org-4107	1136	5	nucleus	nucleus	NN
en-wikipedia-org-4107	1136	6	accumbens	accumben	NNS
en-wikipedia-org-4107	1136	7	induces	induce	NNS
en-wikipedia-org-4107	1136	8	NFκB	nfκb	ADD
en-wikipedia-org-4107	1136	9	 	  	_SP
en-wikipedia-org-4107	1136	10	...	...	.
en-wikipedia-org-4107	1137	1	In	in	IN
en-wikipedia-org-4107	1137	2	contrast	contrast	NN
en-wikipedia-org-4107	1137	3	,	,	,
en-wikipedia-org-4107	1137	4	the	the	DT
en-wikipedia-org-4107	1137	5	ability	ability	NN
en-wikipedia-org-4107	1137	6	of	of	IN
en-wikipedia-org-4107	1137	7	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1137	8	to	to	TO
en-wikipedia-org-4107	1137	9	repress	repress	VB
en-wikipedia-org-4107	1137	10	the	the	DT
en-wikipedia-org-4107	1137	11	c	c	NNP
en-wikipedia-org-4107	1137	12	-	-	HYPH
en-wikipedia-org-4107	1137	13	Fos	fos	NN
en-wikipedia-org-4107	1137	14	gene	gene	NN
en-wikipedia-org-4107	1137	15	occurs	occur	VBZ
en-wikipedia-org-4107	1137	16	in	in	IN
en-wikipedia-org-4107	1137	17	concert	concert	NN
en-wikipedia-org-4107	1137	18	with	with	IN
en-wikipedia-org-4107	1137	19	the	the	DT
en-wikipedia-org-4107	1137	20	recruitment	recruitment	NN
en-wikipedia-org-4107	1137	21	of	of	IN
en-wikipedia-org-4107	1137	22	a	a	DT
en-wikipedia-org-4107	1137	23	histone	histone	JJ
en-wikipedia-org-4107	1137	24	deacetylase	deacetylase	NN
en-wikipedia-org-4107	1137	25	and	and	CC
en-wikipedia-org-4107	1137	26	presumably	presumably	RB
en-wikipedia-org-4107	1137	27	several	several	JJ
en-wikipedia-org-4107	1137	28	other	other	JJ
en-wikipedia-org-4107	1137	29	repressive	repressive	JJ
en-wikipedia-org-4107	1137	30	proteins	protein	NNS
en-wikipedia-org-4107	1137	31	such	such	JJ
en-wikipedia-org-4107	1137	32	as	as	IN
en-wikipedia-org-4107	1137	33	a	a	DT
en-wikipedia-org-4107	1137	34	repressive	repressive	JJ
en-wikipedia-org-4107	1137	35	histone	histone	NN
en-wikipedia-org-4107	1137	36	methyltransferase	methyltransferase	NN
en-wikipedia-org-4107	1137	37	^	^	.
en-wikipedia-org-4107	1137	38	Nestler	Nestler	NNP
en-wikipedia-org-4107	1137	39	EJ	EJ	NNP
en-wikipedia-org-4107	1137	40	(	(	-LRB-
en-wikipedia-org-4107	1137	41	October	October	NNP
en-wikipedia-org-4107	1137	42	2008	2008	CD
en-wikipedia-org-4107	1137	43	)	)	-RRB-
en-wikipedia-org-4107	1137	44	.	.	.
en-wikipedia-org-4107	1138	1	"	"	``
en-wikipedia-org-4107	1138	2	Transcriptional	transcriptional	JJ
en-wikipedia-org-4107	1138	3	mechanisms	mechanism	NNS
en-wikipedia-org-4107	1138	4	of	of	IN
en-wikipedia-org-4107	1138	5	addiction	addiction	NN
en-wikipedia-org-4107	1138	6	:	:	:
en-wikipedia-org-4107	1138	7	Role	role	NN
en-wikipedia-org-4107	1138	8	of	of	IN
en-wikipedia-org-4107	1138	9	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1138	10	"	"	''
en-wikipedia-org-4107	1138	11	.	.	.
en-wikipedia-org-4107	1139	1	Philosophical	philosophical	JJ
en-wikipedia-org-4107	1139	2	Transactions	Transactions	NNPS
en-wikipedia-org-4107	1139	3	of	of	IN
en-wikipedia-org-4107	1139	4	the	the	DT
en-wikipedia-org-4107	1139	5	Royal	Royal	NNP
en-wikipedia-org-4107	1139	6	Society	Society	NNP
en-wikipedia-org-4107	1139	7	B	B	NNP
en-wikipedia-org-4107	1139	8	:	:	:
en-wikipedia-org-4107	1139	9	Biological	Biological	NNP
en-wikipedia-org-4107	1139	10	Sciences	Sciences	NNPS
en-wikipedia-org-4107	1139	11	.	.	.
en-wikipedia-org-4107	1140	1	363	363	CD
en-wikipedia-org-4107	1140	2	(	(	-LRB-
en-wikipedia-org-4107	1140	3	1507	1507	CD
en-wikipedia-org-4107	1140	4	)	)	-RRB-
en-wikipedia-org-4107	1140	5	:	:	:
en-wikipedia-org-4107	1140	6	3245–3255	3245–3255	CD
en-wikipedia-org-4107	1140	7	.	.	.
en-wikipedia-org-4107	1141	1	doi:10.1098	doi:10.1098	NNP
en-wikipedia-org-4107	1141	2	/	/	SYM
en-wikipedia-org-4107	1141	3	rstb.2008.0067	rstb.2008.0067	:
en-wikipedia-org-4107	1141	4	.	.	.
en-wikipedia-org-4107	1142	1	PMC	PMC	NNP
en-wikipedia-org-4107	1142	2	 	  	_SP
en-wikipedia-org-4107	1142	3	2607320	2607320	CD
en-wikipedia-org-4107	1142	4	.	.	.
en-wikipedia-org-4107	1143	1	PMID	PMID	NNP
en-wikipedia-org-4107	1143	2	 	  	_SP
en-wikipedia-org-4107	1143	3	18640924	18640924	CD
en-wikipedia-org-4107	1143	4	.	.	.
en-wikipedia-org-4107	1144	1	Recent	recent	JJ
en-wikipedia-org-4107	1144	2	evidence	evidence	NN
en-wikipedia-org-4107	1144	3	has	have	VBZ
en-wikipedia-org-4107	1144	4	shown	show	VBN
en-wikipedia-org-4107	1144	5	that	that	WDT
en-wikipedia-org-4107	1144	6	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1144	7	also	also	RB
en-wikipedia-org-4107	1144	8	represses	repress	VBZ
en-wikipedia-org-4107	1144	9	the	the	DT
en-wikipedia-org-4107	1144	10	c	c	NN
en-wikipedia-org-4107	1144	11	-	-	HYPH
en-wikipedia-org-4107	1144	12	fos	fos	NN
en-wikipedia-org-4107	1144	13	gene	gene	NN
en-wikipedia-org-4107	1144	14	that	that	WDT
en-wikipedia-org-4107	1144	15	helps	help	VBZ
en-wikipedia-org-4107	1144	16	create	create	VB
en-wikipedia-org-4107	1144	17	the	the	DT
en-wikipedia-org-4107	1144	18	molecular	molecular	JJ
en-wikipedia-org-4107	1144	19	switch	switch	NN
en-wikipedia-org-4107	1144	20	—	—	:
en-wikipedia-org-4107	1144	21	from	from	IN
en-wikipedia-org-4107	1144	22	the	the	DT
en-wikipedia-org-4107	1144	23	induction	induction	NN
en-wikipedia-org-4107	1144	24	of	of	IN
en-wikipedia-org-4107	1144	25	several	several	JJ
en-wikipedia-org-4107	1144	26	short	short	RB
en-wikipedia-org-4107	1144	27	-	-	HYPH
en-wikipedia-org-4107	1144	28	lived	live	VBN
en-wikipedia-org-4107	1144	29	Fos	Fos	NNP
en-wikipedia-org-4107	1144	30	family	family	NN
en-wikipedia-org-4107	1144	31	proteins	protein	NNS
en-wikipedia-org-4107	1144	32	after	after	IN
en-wikipedia-org-4107	1144	33	acute	acute	JJ
en-wikipedia-org-4107	1144	34	drug	drug	NN
en-wikipedia-org-4107	1144	35	exposure	exposure	NN
en-wikipedia-org-4107	1144	36	to	to	IN
en-wikipedia-org-4107	1144	37	the	the	DT
en-wikipedia-org-4107	1144	38	predominant	predominant	JJ
en-wikipedia-org-4107	1144	39	accumulation	accumulation	NN
en-wikipedia-org-4107	1144	40	of	of	IN
en-wikipedia-org-4107	1144	41	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1144	42	after	after	IN
en-wikipedia-org-4107	1144	43	chronic	chronic	JJ
en-wikipedia-org-4107	1144	44	drug	drug	NN
en-wikipedia-org-4107	1144	45	exposure	exposure	NN
en-wikipedia-org-4107	1144	46	^	^	NN
en-wikipedia-org-4107	1144	47	Kanehisa	Kanehisa	NNP
en-wikipedia-org-4107	1144	48	Laboratories	Laboratories	NNP
en-wikipedia-org-4107	1144	49	(	(	-LRB-
en-wikipedia-org-4107	1144	50	10	10	CD
en-wikipedia-org-4107	1144	51	October	October	NNP
en-wikipedia-org-4107	1144	52	2014	2014	CD
en-wikipedia-org-4107	1144	53	)	)	-RRB-
en-wikipedia-org-4107	1144	54	.	.	.
en-wikipedia-org-4107	1145	1	"	"	``
en-wikipedia-org-4107	1145	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1145	3	–	–	:
en-wikipedia-org-4107	1145	4	Homo	Homo	NNP
en-wikipedia-org-4107	1145	5	sapiens	sapiens	JJ
en-wikipedia-org-4107	1145	6	(	(	-LRB-
en-wikipedia-org-4107	1145	7	human	human	JJ
en-wikipedia-org-4107	1145	8	)	)	-RRB-
en-wikipedia-org-4107	1145	9	"	"	''
en-wikipedia-org-4107	1145	10	.	.	.
en-wikipedia-org-4107	1146	1	KEGG	KEGG	NNP
en-wikipedia-org-4107	1146	2	Pathway	Pathway	NNP
en-wikipedia-org-4107	1146	3	.	.	.
en-wikipedia-org-4107	1147	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1147	2	31	31	CD
en-wikipedia-org-4107	1147	3	October	October	NNP
en-wikipedia-org-4107	1147	4	2014	2014	CD
en-wikipedia-org-4107	1147	5	.	.	.
en-wikipedia-org-4107	1148	1	^	^	NNP
en-wikipedia-org-4107	1148	2	a	a	DT
en-wikipedia-org-4107	1148	3	b	b	NNP
en-wikipedia-org-4107	1148	4	c	c	NNP
en-wikipedia-org-4107	1148	5	d	d	NN
en-wikipedia-org-4107	1148	6	e	e	NNP
en-wikipedia-org-4107	1148	7	f	f	NNP
en-wikipedia-org-4107	1148	8	Nechifor	Nechifor	NNP
en-wikipedia-org-4107	1148	9	M	M	NNP
en-wikipedia-org-4107	1148	10	(	(	-LRB-
en-wikipedia-org-4107	1148	11	March	March	NNP
en-wikipedia-org-4107	1148	12	2008	2008	CD
en-wikipedia-org-4107	1148	13	)	)	-RRB-
en-wikipedia-org-4107	1148	14	.	.	.
en-wikipedia-org-4107	1149	1	"	"	``
en-wikipedia-org-4107	1149	2	Magnesium	magnesium	NN
en-wikipedia-org-4107	1149	3	in	in	IN
en-wikipedia-org-4107	1149	4	drug	drug	NN
en-wikipedia-org-4107	1149	5	dependences	dependence	NNS
en-wikipedia-org-4107	1149	6	"	"	''
en-wikipedia-org-4107	1149	7	.	.	.
en-wikipedia-org-4107	1150	1	Magnesium	Magnesium	NNP
en-wikipedia-org-4107	1150	2	Research	Research	NNP
en-wikipedia-org-4107	1150	3	.	.	.
en-wikipedia-org-4107	1151	1	21	21	CD
en-wikipedia-org-4107	1151	2	(	(	-LRB-
en-wikipedia-org-4107	1151	3	1	1	CD
en-wikipedia-org-4107	1151	4	)	)	-RRB-
en-wikipedia-org-4107	1151	5	:	:	:
en-wikipedia-org-4107	1151	6	5–15	5–15	CD
en-wikipedia-org-4107	1151	7	.	.	.
en-wikipedia-org-4107	1152	1	doi:10.1684	doi:10.1684	NNP
en-wikipedia-org-4107	1152	2	/	/	SYM
en-wikipedia-org-4107	1152	3	mrh.2008.0124	mrh.2008.0124	NNP
en-wikipedia-org-4107	1152	4	(	(	-LRB-
en-wikipedia-org-4107	1152	5	inactive	inactive	JJ
en-wikipedia-org-4107	1152	6	8	8	CD
en-wikipedia-org-4107	1152	7	November	November	NNP
en-wikipedia-org-4107	1152	8	2020	2020	CD
en-wikipedia-org-4107	1152	9	)	)	-RRB-
en-wikipedia-org-4107	1152	10	.	.	.
en-wikipedia-org-4107	1153	1	PMID	PMID	NNP
en-wikipedia-org-4107	1153	2	 	  	_SP
en-wikipedia-org-4107	1153	3	18557129.CS1	18557129.CS1	NNP
en-wikipedia-org-4107	1153	4	maint	maint	NN
en-wikipedia-org-4107	1153	5	:	:	:
en-wikipedia-org-4107	1153	6	DOI	doi	NN
en-wikipedia-org-4107	1153	7	inactive	inactive	JJ
en-wikipedia-org-4107	1153	8	as	as	IN
en-wikipedia-org-4107	1153	9	of	of	IN
en-wikipedia-org-4107	1153	10	November	November	NNP
en-wikipedia-org-4107	1153	11	2020	2020	CD
en-wikipedia-org-4107	1153	12	(	(	-LRB-
en-wikipedia-org-4107	1153	13	link	link	NN
en-wikipedia-org-4107	1153	14	)	)	-RRB-
en-wikipedia-org-4107	1153	15	^	^	FW
en-wikipedia-org-4107	1153	16	a	a	DT
en-wikipedia-org-4107	1153	17	b	b	NN
en-wikipedia-org-4107	1153	18	c	c	NN
en-wikipedia-org-4107	1153	19	d	d	NN
en-wikipedia-org-4107	1153	20	e	e	NN
en-wikipedia-org-4107	1153	21	Ruffle	Ruffle	NNP
en-wikipedia-org-4107	1153	22	JK	JK	NNP
en-wikipedia-org-4107	1153	23	(	(	-LRB-
en-wikipedia-org-4107	1153	24	November	November	NNP
en-wikipedia-org-4107	1153	25	2014	2014	CD
en-wikipedia-org-4107	1153	26	)	)	-RRB-
en-wikipedia-org-4107	1153	27	.	.	.
en-wikipedia-org-4107	1154	1	"	"	``
en-wikipedia-org-4107	1154	2	Molecular	molecular	JJ
en-wikipedia-org-4107	1154	3	neurobiology	neurobiology	NN
en-wikipedia-org-4107	1154	4	of	of	IN
en-wikipedia-org-4107	1154	5	addiction	addiction	NN
en-wikipedia-org-4107	1154	6	:	:	:
en-wikipedia-org-4107	1154	7	what	what	WP
en-wikipedia-org-4107	1154	8	's	be	VBZ
en-wikipedia-org-4107	1154	9	all	all	PDT
en-wikipedia-org-4107	1154	10	the	the	DT
en-wikipedia-org-4107	1154	11	(	(	-LRB-
en-wikipedia-org-4107	1154	12	Δ)FosB	Δ)FosB	NNP
en-wikipedia-org-4107	1154	13	about	about	IN
en-wikipedia-org-4107	1154	14	?	?	.
en-wikipedia-org-4107	1154	15	"	"	''
en-wikipedia-org-4107	1154	16	.	.	.
en-wikipedia-org-4107	1155	1	The	the	DT
en-wikipedia-org-4107	1155	2	American	American	NNP
en-wikipedia-org-4107	1155	3	Journal	Journal	NNP
en-wikipedia-org-4107	1155	4	of	of	IN
en-wikipedia-org-4107	1155	5	Drug	Drug	NNP
en-wikipedia-org-4107	1155	6	and	and	CC
en-wikipedia-org-4107	1155	7	Alcohol	Alcohol	NNP
en-wikipedia-org-4107	1155	8	Abuse	Abuse	NNP
en-wikipedia-org-4107	1155	9	.	.	.
en-wikipedia-org-4107	1156	1	40	40	CD
en-wikipedia-org-4107	1156	2	(	(	-LRB-
en-wikipedia-org-4107	1156	3	6	6	CD
en-wikipedia-org-4107	1156	4	)	)	-RRB-
en-wikipedia-org-4107	1156	5	:	:	:
en-wikipedia-org-4107	1156	6	428–437	428–437	CD
en-wikipedia-org-4107	1156	7	.	.	.
en-wikipedia-org-4107	1157	1	doi:10.3109/00952990.2014.933840	doi:10.3109/00952990.2014.933840	NNP
en-wikipedia-org-4107	1157	2	.	.	.
en-wikipedia-org-4107	1158	1	PMID	PMID	NNP
en-wikipedia-org-4107	1158	2	 	  	_SP
en-wikipedia-org-4107	1158	3	25083822	25083822	CD
en-wikipedia-org-4107	1158	4	.	.	.
en-wikipedia-org-4107	1159	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1159	2	 	  	_SP
en-wikipedia-org-4107	1159	3	19157711	19157711	CD
en-wikipedia-org-4107	1159	4	.	.	.
en-wikipedia-org-4107	1160	1	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1160	2	is	be	VBZ
en-wikipedia-org-4107	1160	3	an	an	DT
en-wikipedia-org-4107	1160	4	essential	essential	JJ
en-wikipedia-org-4107	1160	5	transcription	transcription	NN
en-wikipedia-org-4107	1160	6	factor	factor	NN
en-wikipedia-org-4107	1160	7	implicated	implicate	VBN
en-wikipedia-org-4107	1160	8	in	in	IN
en-wikipedia-org-4107	1160	9	the	the	DT
en-wikipedia-org-4107	1160	10	molecular	molecular	JJ
en-wikipedia-org-4107	1160	11	and	and	CC
en-wikipedia-org-4107	1160	12	behavioral	behavioral	JJ
en-wikipedia-org-4107	1160	13	pathways	pathway	NNS
en-wikipedia-org-4107	1160	14	of	of	IN
en-wikipedia-org-4107	1160	15	addiction	addiction	NN
en-wikipedia-org-4107	1160	16	following	follow	VBG
en-wikipedia-org-4107	1160	17	repeated	repeat	VBN
en-wikipedia-org-4107	1160	18	drug	drug	NN
en-wikipedia-org-4107	1160	19	exposure	exposure	NN
en-wikipedia-org-4107	1160	20	.	.	.
en-wikipedia-org-4107	1161	1	^	^	NNP
en-wikipedia-org-4107	1161	2	a	a	DT
en-wikipedia-org-4107	1161	3	b	b	NNP
en-wikipedia-org-4107	1161	4	c	c	NNP
en-wikipedia-org-4107	1161	5	d	d	NNP
en-wikipedia-org-4107	1161	6	e	e	NNP
en-wikipedia-org-4107	1161	7	f	f	NNP
en-wikipedia-org-4107	1161	8	g	g	NNP
en-wikipedia-org-4107	1161	9	h	h	NNP
en-wikipedia-org-4107	1161	10	i	i	NN
en-wikipedia-org-4107	1161	11	j	j	NNP
en-wikipedia-org-4107	1161	12	k	k	NN
en-wikipedia-org-4107	1161	13	Robison	Robison	NNP
en-wikipedia-org-4107	1161	14	AJ	AJ	NNP
en-wikipedia-org-4107	1161	15	,	,	,
en-wikipedia-org-4107	1161	16	Nestler	Nestler	NNP
en-wikipedia-org-4107	1161	17	EJ	EJ	NNP
en-wikipedia-org-4107	1161	18	(	(	-LRB-
en-wikipedia-org-4107	1161	19	November	November	NNP
en-wikipedia-org-4107	1161	20	2011	2011	CD
en-wikipedia-org-4107	1161	21	)	)	-RRB-
en-wikipedia-org-4107	1161	22	.	.	.
en-wikipedia-org-4107	1162	1	"	"	``
en-wikipedia-org-4107	1162	2	Transcriptional	transcriptional	JJ
en-wikipedia-org-4107	1162	3	and	and	CC
en-wikipedia-org-4107	1162	4	epigenetic	epigenetic	JJ
en-wikipedia-org-4107	1162	5	mechanisms	mechanism	NNS
en-wikipedia-org-4107	1162	6	of	of	IN
en-wikipedia-org-4107	1162	7	addiction	addiction	NN
en-wikipedia-org-4107	1162	8	"	"	''
en-wikipedia-org-4107	1162	9	.	.	.
en-wikipedia-org-4107	1163	1	Nature	Nature	NNP
en-wikipedia-org-4107	1163	2	Reviews	review	NNS
en-wikipedia-org-4107	1163	3	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1163	4	.	.	.
en-wikipedia-org-4107	1164	1	12	12	CD
en-wikipedia-org-4107	1164	2	(	(	-LRB-
en-wikipedia-org-4107	1164	3	11	11	CD
en-wikipedia-org-4107	1164	4	)	)	-RRB-
en-wikipedia-org-4107	1164	5	:	:	:
en-wikipedia-org-4107	1164	6	623–637	623–637	CD
en-wikipedia-org-4107	1164	7	.	.	.
en-wikipedia-org-4107	1165	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-4107	1165	2	/	/	SYM
en-wikipedia-org-4107	1165	3	nrn3111	nrn3111	NNP
en-wikipedia-org-4107	1165	4	.	.	.
en-wikipedia-org-4107	1166	1	PMC	PMC	NNP
en-wikipedia-org-4107	1166	2	 	  	_SP
en-wikipedia-org-4107	1166	3	3272277	3272277	CD
en-wikipedia-org-4107	1166	4	.	.	.
en-wikipedia-org-4107	1167	1	PMID	PMID	NNP
en-wikipedia-org-4107	1167	2	 	  	_SP
en-wikipedia-org-4107	1167	3	21989194	21989194	CD
en-wikipedia-org-4107	1167	4	.	.	.
en-wikipedia-org-4107	1168	1	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1168	2	has	have	VBZ
en-wikipedia-org-4107	1168	3	been	be	VBN
en-wikipedia-org-4107	1168	4	linked	link	VBN
en-wikipedia-org-4107	1168	5	directly	directly	RB
en-wikipedia-org-4107	1168	6	to	to	IN
en-wikipedia-org-4107	1168	7	several	several	JJ
en-wikipedia-org-4107	1168	8	addiction	addiction	NN
en-wikipedia-org-4107	1168	9	-	-	HYPH
en-wikipedia-org-4107	1168	10	related	relate	VBN
en-wikipedia-org-4107	1168	11	behaviors	behavior	NNS
en-wikipedia-org-4107	1168	12	 	  	_SP
en-wikipedia-org-4107	1168	13	...	...	:
en-wikipedia-org-4107	1169	1	Importantly	importantly	RB
en-wikipedia-org-4107	1169	2	,	,	,
en-wikipedia-org-4107	1169	3	genetic	genetic	JJ
en-wikipedia-org-4107	1169	4	or	or	CC
en-wikipedia-org-4107	1169	5	viral	viral	JJ
en-wikipedia-org-4107	1169	6	overexpression	overexpression	NN
en-wikipedia-org-4107	1169	7	of	of	IN
en-wikipedia-org-4107	1169	8	ΔJunD	δjund	NN
en-wikipedia-org-4107	1169	9	,	,	,
en-wikipedia-org-4107	1169	10	a	a	DT
en-wikipedia-org-4107	1169	11	dominant	dominant	JJ
en-wikipedia-org-4107	1169	12	negative	negative	JJ
en-wikipedia-org-4107	1169	13	mutant	mutant	NN
en-wikipedia-org-4107	1169	14	of	of	IN
en-wikipedia-org-4107	1169	15	JunD	JunD	NNP
en-wikipedia-org-4107	1169	16	which	which	WDT
en-wikipedia-org-4107	1169	17	antagonizes	antagonize	VBZ
en-wikipedia-org-4107	1169	18	ΔFosB-	ΔFosB-	NNP
en-wikipedia-org-4107	1169	19	and	and	CC
en-wikipedia-org-4107	1169	20	other	other	JJ
en-wikipedia-org-4107	1169	21	AP-1-mediated	ap-1-mediated	JJ
en-wikipedia-org-4107	1169	22	transcriptional	transcriptional	JJ
en-wikipedia-org-4107	1169	23	activity	activity	NN
en-wikipedia-org-4107	1169	24	,	,	,
en-wikipedia-org-4107	1169	25	in	in	IN
en-wikipedia-org-4107	1169	26	the	the	DT
en-wikipedia-org-4107	1169	27	NAc	NAc	NNS
en-wikipedia-org-4107	1169	28	or	or	CC
en-wikipedia-org-4107	1169	29	OFC	OFC	NNP
en-wikipedia-org-4107	1169	30	blocks	block	NNS
en-wikipedia-org-4107	1169	31	these	these	DT
en-wikipedia-org-4107	1169	32	key	key	JJ
en-wikipedia-org-4107	1169	33	effects	effect	NNS
en-wikipedia-org-4107	1169	34	of	of	IN
en-wikipedia-org-4107	1169	35	drug	drug	NN
en-wikipedia-org-4107	1169	36	exposure14,22–24	exposure14,22–24	UH
en-wikipedia-org-4107	1169	37	.	.	.
en-wikipedia-org-4107	1170	1	This	this	DT
en-wikipedia-org-4107	1170	2	indicates	indicate	VBZ
en-wikipedia-org-4107	1170	3	that	that	IN
en-wikipedia-org-4107	1170	4	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1170	5	is	be	VBZ
en-wikipedia-org-4107	1170	6	both	both	CC
en-wikipedia-org-4107	1170	7	necessary	necessary	JJ
en-wikipedia-org-4107	1170	8	and	and	CC
en-wikipedia-org-4107	1170	9	sufficient	sufficient	JJ
en-wikipedia-org-4107	1170	10	for	for	IN
en-wikipedia-org-4107	1170	11	many	many	JJ
en-wikipedia-org-4107	1170	12	of	of	IN
en-wikipedia-org-4107	1170	13	the	the	DT
en-wikipedia-org-4107	1170	14	changes	change	NNS
en-wikipedia-org-4107	1170	15	wrought	work	VBD
en-wikipedia-org-4107	1170	16	in	in	IN
en-wikipedia-org-4107	1170	17	the	the	DT
en-wikipedia-org-4107	1170	18	brain	brain	NN
en-wikipedia-org-4107	1170	19	by	by	IN
en-wikipedia-org-4107	1170	20	chronic	chronic	JJ
en-wikipedia-org-4107	1170	21	drug	drug	NN
en-wikipedia-org-4107	1170	22	exposure	exposure	NN
en-wikipedia-org-4107	1170	23	.	.	.
en-wikipedia-org-4107	1171	1	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1171	2	is	be	VBZ
en-wikipedia-org-4107	1171	3	also	also	RB
en-wikipedia-org-4107	1171	4	induced	induce	VBN
en-wikipedia-org-4107	1171	5	in	in	IN
en-wikipedia-org-4107	1171	6	D1-type	D1-type	NNP
en-wikipedia-org-4107	1171	7	NAc	NAc	NNP
en-wikipedia-org-4107	1171	8	MSNs	msn	NNS
en-wikipedia-org-4107	1171	9	by	by	IN
en-wikipedia-org-4107	1171	10	chronic	chronic	JJ
en-wikipedia-org-4107	1171	11	consumption	consumption	NN
en-wikipedia-org-4107	1171	12	of	of	IN
en-wikipedia-org-4107	1171	13	several	several	JJ
en-wikipedia-org-4107	1171	14	natural	natural	JJ
en-wikipedia-org-4107	1171	15	rewards	reward	NNS
en-wikipedia-org-4107	1171	16	,	,	,
en-wikipedia-org-4107	1171	17	including	include	VBG
en-wikipedia-org-4107	1171	18	sucrose	sucrose	JJ
en-wikipedia-org-4107	1171	19	,	,	,
en-wikipedia-org-4107	1171	20	high	high	JJ
en-wikipedia-org-4107	1171	21	fat	fat	NN
en-wikipedia-org-4107	1171	22	food	food	NN
en-wikipedia-org-4107	1171	23	,	,	,
en-wikipedia-org-4107	1171	24	sex	sex	NN
en-wikipedia-org-4107	1171	25	,	,	,
en-wikipedia-org-4107	1171	26	wheel	wheel	NN
en-wikipedia-org-4107	1171	27	running	running	NN
en-wikipedia-org-4107	1171	28	,	,	,
en-wikipedia-org-4107	1171	29	where	where	WRB
en-wikipedia-org-4107	1171	30	it	-PRON-	PRP
en-wikipedia-org-4107	1171	31	promotes	promote	VBZ
en-wikipedia-org-4107	1171	32	that	that	IN
en-wikipedia-org-4107	1171	33	consumption14,26–30	consumption14,26–30	NNP
en-wikipedia-org-4107	1171	34	.	.	.
en-wikipedia-org-4107	1172	1	This	this	DT
en-wikipedia-org-4107	1172	2	implicates	implicate	NNS
en-wikipedia-org-4107	1172	3	ΔFosB	ΔFosB	VBZ
en-wikipedia-org-4107	1172	4	in	in	IN
en-wikipedia-org-4107	1172	5	the	the	DT
en-wikipedia-org-4107	1172	6	regulation	regulation	NN
en-wikipedia-org-4107	1172	7	of	of	IN
en-wikipedia-org-4107	1172	8	natural	natural	JJ
en-wikipedia-org-4107	1172	9	rewards	reward	NNS
en-wikipedia-org-4107	1172	10	under	under	IN
en-wikipedia-org-4107	1172	11	normal	normal	JJ
en-wikipedia-org-4107	1172	12	conditions	condition	NNS
en-wikipedia-org-4107	1172	13	and	and	CC
en-wikipedia-org-4107	1172	14	perhaps	perhaps	RB
en-wikipedia-org-4107	1172	15	during	during	IN
en-wikipedia-org-4107	1172	16	pathological	pathological	JJ
en-wikipedia-org-4107	1172	17	addictive	addictive	JJ
en-wikipedia-org-4107	1172	18	-	-	HYPH
en-wikipedia-org-4107	1172	19	like	like	JJ
en-wikipedia-org-4107	1172	20	states	state	NNS
en-wikipedia-org-4107	1172	21	.	.	.
en-wikipedia-org-4107	1173	1	...	...	NFP
en-wikipedia-org-4107	1173	2	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1173	3	serves	serve	VBZ
en-wikipedia-org-4107	1173	4	as	as	IN
en-wikipedia-org-4107	1173	5	one	one	CD
en-wikipedia-org-4107	1173	6	of	of	IN
en-wikipedia-org-4107	1173	7	the	the	DT
en-wikipedia-org-4107	1173	8	master	master	NN
en-wikipedia-org-4107	1173	9	control	control	NN
en-wikipedia-org-4107	1173	10	proteins	protein	NNS
en-wikipedia-org-4107	1173	11	governing	govern	VBG
en-wikipedia-org-4107	1173	12	this	this	DT
en-wikipedia-org-4107	1173	13	structural	structural	JJ
en-wikipedia-org-4107	1173	14	plasticity	plasticity	NN
en-wikipedia-org-4107	1173	15	.	.	.
en-wikipedia-org-4107	1174	1	^	^	NNP
en-wikipedia-org-4107	1174	2	a	a	DT
en-wikipedia-org-4107	1174	3	b	b	NNP
en-wikipedia-org-4107	1174	4	c	c	NNP
en-wikipedia-org-4107	1174	5	d	d	NNP
en-wikipedia-org-4107	1174	6	e	e	NNP
en-wikipedia-org-4107	1174	7	f	f	NNP
en-wikipedia-org-4107	1174	8	g	g	NNP
en-wikipedia-org-4107	1174	9	h	h	NNP
en-wikipedia-org-4107	1174	10	i	i	NN
en-wikipedia-org-4107	1174	11	j	j	NNP
en-wikipedia-org-4107	1174	12	k	k	NNP
en-wikipedia-org-4107	1174	13	l	l	NNP
en-wikipedia-org-4107	1174	14	m	m	NNP
en-wikipedia-org-4107	1174	15	n	n	CC
en-wikipedia-org-4107	1174	16	o	o	NNP
en-wikipedia-org-4107	1174	17	p	p	NN
en-wikipedia-org-4107	1174	18	q	q	NNP
en-wikipedia-org-4107	1174	19	r	r	NNP
en-wikipedia-org-4107	1174	20	s	s	NNP
en-wikipedia-org-4107	1174	21	t	t	NNP
en-wikipedia-org-4107	1174	22	u	u	NNP
en-wikipedia-org-4107	1174	23	v	v	NNP
en-wikipedia-org-4107	1174	24	Olsen	Olsen	NNP
en-wikipedia-org-4107	1174	25	CM	CM	NNP
en-wikipedia-org-4107	1174	26	(	(	-LRB-
en-wikipedia-org-4107	1174	27	December	December	NNP
en-wikipedia-org-4107	1174	28	2011	2011	CD
en-wikipedia-org-4107	1174	29	)	)	-RRB-
en-wikipedia-org-4107	1174	30	.	.	.
en-wikipedia-org-4107	1175	1	"	"	``
en-wikipedia-org-4107	1175	2	Natural	natural	JJ
en-wikipedia-org-4107	1175	3	rewards	reward	NNS
en-wikipedia-org-4107	1175	4	,	,	,
en-wikipedia-org-4107	1175	5	neuroplasticity	neuroplasticity	NN
en-wikipedia-org-4107	1175	6	,	,	,
en-wikipedia-org-4107	1175	7	and	and	CC
en-wikipedia-org-4107	1175	8	non	non	JJ
en-wikipedia-org-4107	1175	9	-	-	JJ
en-wikipedia-org-4107	1175	10	drug	drug	JJ
en-wikipedia-org-4107	1175	11	addictions	addiction	NNS
en-wikipedia-org-4107	1175	12	"	"	''
en-wikipedia-org-4107	1175	13	.	.	.
en-wikipedia-org-4107	1176	1	Neuropharmacology	neuropharmacology	NN
en-wikipedia-org-4107	1176	2	.	.	.
en-wikipedia-org-4107	1177	1	61	61	CD
en-wikipedia-org-4107	1177	2	(	(	-LRB-
en-wikipedia-org-4107	1177	3	7	7	CD
en-wikipedia-org-4107	1177	4	)	)	-RRB-
en-wikipedia-org-4107	1177	5	:	:	:
en-wikipedia-org-4107	1177	6	1109–1122	1109–1122	CD
en-wikipedia-org-4107	1177	7	.	.	.
en-wikipedia-org-4107	1178	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1178	2	/	/	SYM
en-wikipedia-org-4107	1178	3	j.neuropharm.2011.03.010	j.neuropharm.2011.03.010	NNP
en-wikipedia-org-4107	1178	4	.	.	.
en-wikipedia-org-4107	1179	1	PMC	PMC	NNP
en-wikipedia-org-4107	1179	2	 	  	_SP
en-wikipedia-org-4107	1179	3	3139704	3139704	CD
en-wikipedia-org-4107	1179	4	.	.	.
en-wikipedia-org-4107	1180	1	PMID	PMID	NNP
en-wikipedia-org-4107	1180	2	 	  	_SP
en-wikipedia-org-4107	1180	3	21459101	21459101	CD
en-wikipedia-org-4107	1180	4	.	.	.
en-wikipedia-org-4107	1181	1	Similar	similar	JJ
en-wikipedia-org-4107	1181	2	to	to	IN
en-wikipedia-org-4107	1181	3	environmental	environmental	JJ
en-wikipedia-org-4107	1181	4	enrichment	enrichment	NN
en-wikipedia-org-4107	1181	5	,	,	,
en-wikipedia-org-4107	1181	6	studies	study	NNS
en-wikipedia-org-4107	1181	7	have	have	VBP
en-wikipedia-org-4107	1181	8	found	find	VBN
en-wikipedia-org-4107	1181	9	that	that	DT
en-wikipedia-org-4107	1181	10	exercise	exercise	NN
en-wikipedia-org-4107	1181	11	reduces	reduce	VBZ
en-wikipedia-org-4107	1181	12	self	self	NN
en-wikipedia-org-4107	1181	13	-	-	HYPH
en-wikipedia-org-4107	1181	14	administration	administration	NN
en-wikipedia-org-4107	1181	15	and	and	CC
en-wikipedia-org-4107	1181	16	relapse	relapse	VB
en-wikipedia-org-4107	1181	17	to	to	IN
en-wikipedia-org-4107	1181	18	drugs	drug	NNS
en-wikipedia-org-4107	1181	19	of	of	IN
en-wikipedia-org-4107	1181	20	abuse	abuse	NN
en-wikipedia-org-4107	1181	21	(	(	-LRB-
en-wikipedia-org-4107	1181	22	Cosgrove	Cosgrove	NNP
en-wikipedia-org-4107	1181	23	et	et	FW
en-wikipedia-org-4107	1181	24	al	al	NNP
en-wikipedia-org-4107	1181	25	.	.	NNP
en-wikipedia-org-4107	1181	26	,	,	,
en-wikipedia-org-4107	1181	27	2002	2002	CD
en-wikipedia-org-4107	1181	28	;	;	:
en-wikipedia-org-4107	1181	29	Zlebnik	Zlebnik	NNP
en-wikipedia-org-4107	1181	30	et	et	NNP
en-wikipedia-org-4107	1181	31	al	al	NNP
en-wikipedia-org-4107	1181	32	.	.	NNP
en-wikipedia-org-4107	1181	33	,	,	,
en-wikipedia-org-4107	1181	34	2010	2010	CD
en-wikipedia-org-4107	1181	35	)	)	-RRB-
en-wikipedia-org-4107	1181	36	.	.	.
en-wikipedia-org-4107	1182	1	There	there	EX
en-wikipedia-org-4107	1182	2	is	be	VBZ
en-wikipedia-org-4107	1182	3	also	also	RB
en-wikipedia-org-4107	1182	4	some	some	DT
en-wikipedia-org-4107	1182	5	evidence	evidence	NN
en-wikipedia-org-4107	1182	6	that	that	IN
en-wikipedia-org-4107	1182	7	these	these	DT
en-wikipedia-org-4107	1182	8	preclinical	preclinical	JJ
en-wikipedia-org-4107	1182	9	findings	finding	NNS
en-wikipedia-org-4107	1182	10	translate	translate	VBP
en-wikipedia-org-4107	1182	11	to	to	IN
en-wikipedia-org-4107	1182	12	human	human	JJ
en-wikipedia-org-4107	1182	13	populations	population	NNS
en-wikipedia-org-4107	1182	14	,	,	,
en-wikipedia-org-4107	1182	15	as	as	IN
en-wikipedia-org-4107	1182	16	exercise	exercise	NN
en-wikipedia-org-4107	1182	17	reduces	reduce	VBZ
en-wikipedia-org-4107	1182	18	withdrawal	withdrawal	NN
en-wikipedia-org-4107	1182	19	symptoms	symptom	NNS
en-wikipedia-org-4107	1182	20	and	and	CC
en-wikipedia-org-4107	1182	21	relapse	relapse	VB
en-wikipedia-org-4107	1182	22	in	in	IN
en-wikipedia-org-4107	1182	23	abstinent	abstinent	JJ
en-wikipedia-org-4107	1182	24	smokers	smoker	NNS
en-wikipedia-org-4107	1182	25	(	(	-LRB-
en-wikipedia-org-4107	1182	26	Daniel	Daniel	NNP
en-wikipedia-org-4107	1182	27	et	et	NNP
en-wikipedia-org-4107	1182	28	al	al	NNP
en-wikipedia-org-4107	1182	29	.	.	NNP
en-wikipedia-org-4107	1182	30	,	,	,
en-wikipedia-org-4107	1182	31	2006	2006	CD
en-wikipedia-org-4107	1182	32	;	;	:
en-wikipedia-org-4107	1182	33	Prochaska	Prochaska	NNP
en-wikipedia-org-4107	1182	34	et	et	FW
en-wikipedia-org-4107	1182	35	al	al	NNP
en-wikipedia-org-4107	1182	36	.	.	NNP
en-wikipedia-org-4107	1182	37	,	,	,
en-wikipedia-org-4107	1182	38	2008	2008	CD
en-wikipedia-org-4107	1182	39	)	)	-RRB-
en-wikipedia-org-4107	1182	40	,	,	,
en-wikipedia-org-4107	1182	41	and	and	CC
en-wikipedia-org-4107	1182	42	one	one	CD
en-wikipedia-org-4107	1182	43	drug	drug	NN
en-wikipedia-org-4107	1182	44	recovery	recovery	NN
en-wikipedia-org-4107	1182	45	program	program	NN
en-wikipedia-org-4107	1182	46	has	have	VBZ
en-wikipedia-org-4107	1182	47	seen	see	VBN
en-wikipedia-org-4107	1182	48	success	success	NN
en-wikipedia-org-4107	1182	49	in	in	IN
en-wikipedia-org-4107	1182	50	participants	participant	NNS
en-wikipedia-org-4107	1182	51	that	that	WDT
en-wikipedia-org-4107	1182	52	train	train	VBP
en-wikipedia-org-4107	1182	53	for	for	IN
en-wikipedia-org-4107	1182	54	and	and	CC
en-wikipedia-org-4107	1182	55	compete	compete	VB
en-wikipedia-org-4107	1182	56	in	in	IN
en-wikipedia-org-4107	1182	57	a	a	DT
en-wikipedia-org-4107	1182	58	marathon	marathon	NN
en-wikipedia-org-4107	1182	59	as	as	IN
en-wikipedia-org-4107	1182	60	part	part	NN
en-wikipedia-org-4107	1182	61	of	of	IN
en-wikipedia-org-4107	1182	62	the	the	DT
en-wikipedia-org-4107	1182	63	program	program	NN
en-wikipedia-org-4107	1182	64	(	(	-LRB-
en-wikipedia-org-4107	1182	65	Butler	Butler	NNP
en-wikipedia-org-4107	1182	66	,	,	,
en-wikipedia-org-4107	1182	67	2005	2005	CD
en-wikipedia-org-4107	1182	68	)	)	-RRB-
en-wikipedia-org-4107	1182	69	.	.	.
en-wikipedia-org-4107	1183	1	...	...	NFP
en-wikipedia-org-4107	1184	1	In	in	IN
en-wikipedia-org-4107	1184	2	humans	human	NNS
en-wikipedia-org-4107	1184	3	,	,	,
en-wikipedia-org-4107	1184	4	the	the	DT
en-wikipedia-org-4107	1184	5	role	role	NN
en-wikipedia-org-4107	1184	6	of	of	IN
en-wikipedia-org-4107	1184	7	dopamine	dopamine	NN
en-wikipedia-org-4107	1184	8	signaling	signaling	NN
en-wikipedia-org-4107	1184	9	in	in	IN
en-wikipedia-org-4107	1184	10	incentive	incentive	NN
en-wikipedia-org-4107	1184	11	-	-	HYPH
en-wikipedia-org-4107	1184	12	sensitization	sensitization	NN
en-wikipedia-org-4107	1184	13	processes	process	NNS
en-wikipedia-org-4107	1184	14	has	have	VBZ
en-wikipedia-org-4107	1184	15	recently	recently	RB
en-wikipedia-org-4107	1184	16	been	be	VBN
en-wikipedia-org-4107	1184	17	highlighted	highlight	VBN
en-wikipedia-org-4107	1184	18	by	by	IN
en-wikipedia-org-4107	1184	19	the	the	DT
en-wikipedia-org-4107	1184	20	observation	observation	NN
en-wikipedia-org-4107	1184	21	of	of	IN
en-wikipedia-org-4107	1184	22	a	a	DT
en-wikipedia-org-4107	1184	23	dopamine	dopamine	NN
en-wikipedia-org-4107	1184	24	dysregulation	dysregulation	NN
en-wikipedia-org-4107	1184	25	syndrome	syndrome	NN
en-wikipedia-org-4107	1184	26	in	in	IN
en-wikipedia-org-4107	1184	27	some	some	DT
en-wikipedia-org-4107	1184	28	patients	patient	NNS
en-wikipedia-org-4107	1184	29	taking	take	VBG
en-wikipedia-org-4107	1184	30	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	1184	31	drugs	drug	NNS
en-wikipedia-org-4107	1184	32	.	.	.
en-wikipedia-org-4107	1185	1	This	this	DT
en-wikipedia-org-4107	1185	2	syndrome	syndrome	NN
en-wikipedia-org-4107	1185	3	is	be	VBZ
en-wikipedia-org-4107	1185	4	characterized	characterize	VBN
en-wikipedia-org-4107	1185	5	by	by	IN
en-wikipedia-org-4107	1185	6	a	a	DT
en-wikipedia-org-4107	1185	7	medication	medication	NN
en-wikipedia-org-4107	1185	8	-	-	HYPH
en-wikipedia-org-4107	1185	9	induced	induce	VBN
en-wikipedia-org-4107	1185	10	increase	increase	NN
en-wikipedia-org-4107	1185	11	in	in	IN
en-wikipedia-org-4107	1185	12	(	(	-LRB-
en-wikipedia-org-4107	1185	13	or	or	CC
en-wikipedia-org-4107	1185	14	compulsive	compulsive	JJ
en-wikipedia-org-4107	1185	15	)	)	-RRB-
en-wikipedia-org-4107	1185	16	engagement	engagement	NN
en-wikipedia-org-4107	1185	17	in	in	IN
en-wikipedia-org-4107	1185	18	non	non	JJ
en-wikipedia-org-4107	1185	19	-	-	JJ
en-wikipedia-org-4107	1185	20	drug	drug	JJ
en-wikipedia-org-4107	1185	21	rewards	reward	NNS
en-wikipedia-org-4107	1185	22	such	such	JJ
en-wikipedia-org-4107	1185	23	as	as	IN
en-wikipedia-org-4107	1185	24	gambling	gambling	NN
en-wikipedia-org-4107	1185	25	,	,	,
en-wikipedia-org-4107	1185	26	shopping	shopping	NN
en-wikipedia-org-4107	1185	27	,	,	,
en-wikipedia-org-4107	1185	28	or	or	CC
en-wikipedia-org-4107	1185	29	sex	sex	NN
en-wikipedia-org-4107	1185	30	(	(	-LRB-
en-wikipedia-org-4107	1185	31	Evans	Evans	NNP
en-wikipedia-org-4107	1185	32	et	et	NNP
en-wikipedia-org-4107	1185	33	al	al	NNP
en-wikipedia-org-4107	1185	34	.	.	NNP
en-wikipedia-org-4107	1185	35	,	,	,
en-wikipedia-org-4107	1185	36	2006	2006	CD
en-wikipedia-org-4107	1185	37	;	;	:
en-wikipedia-org-4107	1185	38	Aiken	Aiken	NNP
en-wikipedia-org-4107	1185	39	,	,	,
en-wikipedia-org-4107	1185	40	2007	2007	CD
en-wikipedia-org-4107	1185	41	;	;	:
en-wikipedia-org-4107	1185	42	Lader	Lader	NNP
en-wikipedia-org-4107	1185	43	,	,	,
en-wikipedia-org-4107	1185	44	2008	2008	CD
en-wikipedia-org-4107	1185	45	)	)	-RRB-
en-wikipedia-org-4107	1185	46	.	.	.
en-wikipedia-org-4107	1186	1	^	^	NNP
en-wikipedia-org-4107	1186	2	a	a	DT
en-wikipedia-org-4107	1186	3	b	b	NN
en-wikipedia-org-4107	1186	4	c	c	NNP
en-wikipedia-org-4107	1186	5	d	d	NN
en-wikipedia-org-4107	1186	6	Lynch	Lynch	NNP
en-wikipedia-org-4107	1186	7	WJ	WJ	NNP
en-wikipedia-org-4107	1186	8	,	,	,
en-wikipedia-org-4107	1186	9	Peterson	Peterson	NNP
en-wikipedia-org-4107	1186	10	AB	AB	NNP
en-wikipedia-org-4107	1186	11	,	,	,
en-wikipedia-org-4107	1186	12	Sanchez	Sanchez	NNP
en-wikipedia-org-4107	1186	13	V	V	NNP
en-wikipedia-org-4107	1186	14	,	,	,
en-wikipedia-org-4107	1186	15	Abel	Abel	NNP
en-wikipedia-org-4107	1186	16	J	J	NNP
en-wikipedia-org-4107	1186	17	,	,	,
en-wikipedia-org-4107	1186	18	Smith	Smith	NNP
en-wikipedia-org-4107	1186	19	MA	MA	NNP
en-wikipedia-org-4107	1186	20	(	(	-LRB-
en-wikipedia-org-4107	1186	21	September	September	NNP
en-wikipedia-org-4107	1186	22	2013	2013	CD
en-wikipedia-org-4107	1186	23	)	)	-RRB-
en-wikipedia-org-4107	1186	24	.	.	.
en-wikipedia-org-4107	1187	1	"	"	``
en-wikipedia-org-4107	1187	2	Exercise	exercise	NN
en-wikipedia-org-4107	1187	3	as	as	IN
en-wikipedia-org-4107	1187	4	a	a	DT
en-wikipedia-org-4107	1187	5	novel	novel	JJ
en-wikipedia-org-4107	1187	6	treatment	treatment	NN
en-wikipedia-org-4107	1187	7	for	for	IN
en-wikipedia-org-4107	1187	8	drug	drug	NN
en-wikipedia-org-4107	1187	9	addiction	addiction	NN
en-wikipedia-org-4107	1187	10	:	:	:
en-wikipedia-org-4107	1187	11	a	a	DT
en-wikipedia-org-4107	1187	12	neurobiological	neurobiological	JJ
en-wikipedia-org-4107	1187	13	and	and	CC
en-wikipedia-org-4107	1187	14	stage	stage	NN
en-wikipedia-org-4107	1187	15	-	-	HYPH
en-wikipedia-org-4107	1187	16	dependent	dependent	JJ
en-wikipedia-org-4107	1187	17	hypothesis	hypothesis	NN
en-wikipedia-org-4107	1187	18	"	"	''
en-wikipedia-org-4107	1187	19	.	.	.
en-wikipedia-org-4107	1188	1	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1188	2	&	&	CC
en-wikipedia-org-4107	1188	3	Biobehavioral	Biobehavioral	NNP
en-wikipedia-org-4107	1188	4	Reviews	Reviews	NNPS
en-wikipedia-org-4107	1188	5	.	.	.
en-wikipedia-org-4107	1189	1	37	37	CD
en-wikipedia-org-4107	1189	2	(	(	-LRB-
en-wikipedia-org-4107	1189	3	8)	8)	CD
en-wikipedia-org-4107	1189	4	:	:	:
en-wikipedia-org-4107	1189	5	1622–1644	1622–1644	CD
en-wikipedia-org-4107	1189	6	.	.	.
en-wikipedia-org-4107	1190	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1190	2	/	/	SYM
en-wikipedia-org-4107	1190	3	j.neubiorev.2013.06.011	j.neubiorev.2013.06.011	NN
en-wikipedia-org-4107	1190	4	.	.	.
en-wikipedia-org-4107	1191	1	PMC	PMC	NNP
en-wikipedia-org-4107	1191	2	 	  	_SP
en-wikipedia-org-4107	1191	3	3788047	3788047	CD
en-wikipedia-org-4107	1191	4	.	.	.
en-wikipedia-org-4107	1192	1	PMID	PMID	NNP
en-wikipedia-org-4107	1192	2	 	  	_SP
en-wikipedia-org-4107	1192	3	23806439	23806439	CD
en-wikipedia-org-4107	1192	4	.	.	.
en-wikipedia-org-4107	1193	1	These	these	DT
en-wikipedia-org-4107	1193	2	findings	finding	NNS
en-wikipedia-org-4107	1193	3	suggest	suggest	VBP
en-wikipedia-org-4107	1193	4	that	that	IN
en-wikipedia-org-4107	1193	5	exercise	exercise	NN
en-wikipedia-org-4107	1193	6	may	may	MD
en-wikipedia-org-4107	1193	7	"	"	``
en-wikipedia-org-4107	1193	8	magnitude"-dependently	magnitude"-dependently	RB
en-wikipedia-org-4107	1193	9	prevent	prevent	VB
en-wikipedia-org-4107	1193	10	the	the	DT
en-wikipedia-org-4107	1193	11	development	development	NN
en-wikipedia-org-4107	1193	12	of	of	IN
en-wikipedia-org-4107	1193	13	an	an	DT
en-wikipedia-org-4107	1193	14	addicted	addicted	JJ
en-wikipedia-org-4107	1193	15	phenotype	phenotype	NN
en-wikipedia-org-4107	1193	16	possibly	possibly	RB
en-wikipedia-org-4107	1193	17	by	by	IN
en-wikipedia-org-4107	1193	18	blocking	block	VBG
en-wikipedia-org-4107	1193	19	/	/	SYM
en-wikipedia-org-4107	1193	20	reversing	reverse	VBG
en-wikipedia-org-4107	1193	21	behavioral	behavioral	JJ
en-wikipedia-org-4107	1193	22	and	and	CC
en-wikipedia-org-4107	1193	23	neuroadaptive	neuroadaptive	JJ
en-wikipedia-org-4107	1193	24	changes	change	NNS
en-wikipedia-org-4107	1193	25	that	that	WDT
en-wikipedia-org-4107	1193	26	develop	develop	VBP
en-wikipedia-org-4107	1193	27	during	during	IN
en-wikipedia-org-4107	1193	28	and	and	CC
en-wikipedia-org-4107	1193	29	following	follow	VBG
en-wikipedia-org-4107	1193	30	extended	extended	JJ
en-wikipedia-org-4107	1193	31	access	access	NN
en-wikipedia-org-4107	1193	32	to	to	IN
en-wikipedia-org-4107	1193	33	the	the	DT
en-wikipedia-org-4107	1193	34	drug	drug	NN
en-wikipedia-org-4107	1193	35	.	.	.
en-wikipedia-org-4107	1194	1	...	...	NFP
en-wikipedia-org-4107	1195	1	Exercise	exercise	NN
en-wikipedia-org-4107	1195	2	has	have	VBZ
en-wikipedia-org-4107	1195	3	been	be	VBN
en-wikipedia-org-4107	1195	4	proposed	propose	VBN
en-wikipedia-org-4107	1195	5	as	as	IN
en-wikipedia-org-4107	1195	6	a	a	DT
en-wikipedia-org-4107	1195	7	treatment	treatment	NN
en-wikipedia-org-4107	1195	8	for	for	IN
en-wikipedia-org-4107	1195	9	drug	drug	NN
en-wikipedia-org-4107	1195	10	addiction	addiction	NN
en-wikipedia-org-4107	1195	11	that	that	WDT
en-wikipedia-org-4107	1195	12	may	may	MD
en-wikipedia-org-4107	1195	13	reduce	reduce	VB
en-wikipedia-org-4107	1195	14	drug	drug	NN
en-wikipedia-org-4107	1195	15	craving	craving	NN
en-wikipedia-org-4107	1195	16	and	and	CC
en-wikipedia-org-4107	1195	17	risk	risk	NN
en-wikipedia-org-4107	1195	18	of	of	IN
en-wikipedia-org-4107	1195	19	relapse	relapse	NN
en-wikipedia-org-4107	1195	20	.	.	.
en-wikipedia-org-4107	1196	1	Although	although	IN
en-wikipedia-org-4107	1196	2	few	few	JJ
en-wikipedia-org-4107	1196	3	clinical	clinical	JJ
en-wikipedia-org-4107	1196	4	studies	study	NNS
en-wikipedia-org-4107	1196	5	have	have	VBP
en-wikipedia-org-4107	1196	6	investigated	investigate	VBN
en-wikipedia-org-4107	1196	7	the	the	DT
en-wikipedia-org-4107	1196	8	efficacy	efficacy	NN
en-wikipedia-org-4107	1196	9	of	of	IN
en-wikipedia-org-4107	1196	10	exercise	exercise	NN
en-wikipedia-org-4107	1196	11	for	for	IN
en-wikipedia-org-4107	1196	12	preventing	prevent	VBG
en-wikipedia-org-4107	1196	13	relapse	relapse	NN
en-wikipedia-org-4107	1196	14	,	,	,
en-wikipedia-org-4107	1196	15	the	the	DT
en-wikipedia-org-4107	1196	16	few	few	JJ
en-wikipedia-org-4107	1196	17	studies	study	NNS
en-wikipedia-org-4107	1196	18	that	that	WDT
en-wikipedia-org-4107	1196	19	have	have	VBP
en-wikipedia-org-4107	1196	20	been	be	VBN
en-wikipedia-org-4107	1196	21	conducted	conduct	VBN
en-wikipedia-org-4107	1196	22	generally	generally	RB
en-wikipedia-org-4107	1196	23	report	report	VB
en-wikipedia-org-4107	1196	24	a	a	DT
en-wikipedia-org-4107	1196	25	reduction	reduction	NN
en-wikipedia-org-4107	1196	26	in	in	IN
en-wikipedia-org-4107	1196	27	drug	drug	NN
en-wikipedia-org-4107	1196	28	craving	craving	NN
en-wikipedia-org-4107	1196	29	and	and	CC
en-wikipedia-org-4107	1196	30	better	well	JJR
en-wikipedia-org-4107	1196	31	treatment	treatment	NN
en-wikipedia-org-4107	1196	32	outcomes	outcome	NNS
en-wikipedia-org-4107	1196	33	 	  	_SP
en-wikipedia-org-4107	1196	34	...	...	.
en-wikipedia-org-4107	1196	35	Taken	take	VBN
en-wikipedia-org-4107	1196	36	together	together	RB
en-wikipedia-org-4107	1196	37	,	,	,
en-wikipedia-org-4107	1196	38	these	these	DT
en-wikipedia-org-4107	1196	39	data	datum	NNS
en-wikipedia-org-4107	1196	40	suggest	suggest	VBP
en-wikipedia-org-4107	1196	41	that	that	IN
en-wikipedia-org-4107	1196	42	the	the	DT
en-wikipedia-org-4107	1196	43	potential	potential	JJ
en-wikipedia-org-4107	1196	44	benefits	benefit	NNS
en-wikipedia-org-4107	1196	45	of	of	IN
en-wikipedia-org-4107	1196	46	exercise	exercise	NN
en-wikipedia-org-4107	1196	47	during	during	IN
en-wikipedia-org-4107	1196	48	relapse	relapse	NN
en-wikipedia-org-4107	1196	49	,	,	,
en-wikipedia-org-4107	1196	50	particularly	particularly	RB
en-wikipedia-org-4107	1196	51	for	for	IN
en-wikipedia-org-4107	1196	52	relapse	relapse	NN
en-wikipedia-org-4107	1196	53	to	to	IN
en-wikipedia-org-4107	1196	54	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	1196	55	,	,	,
en-wikipedia-org-4107	1196	56	may	may	MD
en-wikipedia-org-4107	1196	57	be	be	VB
en-wikipedia-org-4107	1196	58	mediated	mediate	VBN
en-wikipedia-org-4107	1196	59	via	via	IN
en-wikipedia-org-4107	1196	60	chromatin	chromatin	NNP
en-wikipedia-org-4107	1196	61	remodeling	remodeling	NNP
en-wikipedia-org-4107	1196	62	and	and	CC
en-wikipedia-org-4107	1196	63	possibly	possibly	RB
en-wikipedia-org-4107	1196	64	lead	lead	VB
en-wikipedia-org-4107	1196	65	to	to	IN
en-wikipedia-org-4107	1196	66	greater	great	JJR
en-wikipedia-org-4107	1196	67	treatment	treatment	NN
en-wikipedia-org-4107	1196	68	outcomes	outcome	NNS
en-wikipedia-org-4107	1196	69	.	.	.
en-wikipedia-org-4107	1197	1	^	^	NNP
en-wikipedia-org-4107	1197	2	a	a	DT
en-wikipedia-org-4107	1197	3	b	b	NN
en-wikipedia-org-4107	1197	4	c	c	NN
en-wikipedia-org-4107	1197	5	Zhou	Zhou	NNP
en-wikipedia-org-4107	1197	6	Y	Y	NNP
en-wikipedia-org-4107	1197	7	,	,	,
en-wikipedia-org-4107	1197	8	Zhao	Zhao	NNP
en-wikipedia-org-4107	1197	9	M	M	NNP
en-wikipedia-org-4107	1197	10	,	,	,
en-wikipedia-org-4107	1197	11	Zhou	Zhou	NNP
en-wikipedia-org-4107	1197	12	C	C	NNP
en-wikipedia-org-4107	1197	13	,	,	,
en-wikipedia-org-4107	1197	14	Li	Li	NNP
en-wikipedia-org-4107	1197	15	R	R	NNP
en-wikipedia-org-4107	1197	16	(	(	-LRB-
en-wikipedia-org-4107	1197	17	July	July	NNP
en-wikipedia-org-4107	1197	18	2015	2015	CD
en-wikipedia-org-4107	1197	19	)	)	-RRB-
en-wikipedia-org-4107	1197	20	.	.	.
en-wikipedia-org-4107	1198	1	"	"	``
en-wikipedia-org-4107	1198	2	Sex	sex	NN
en-wikipedia-org-4107	1198	3	differences	difference	NNS
en-wikipedia-org-4107	1198	4	in	in	IN
en-wikipedia-org-4107	1198	5	drug	drug	NN
en-wikipedia-org-4107	1198	6	addiction	addiction	NN
en-wikipedia-org-4107	1198	7	and	and	CC
en-wikipedia-org-4107	1198	8	response	response	NN
en-wikipedia-org-4107	1198	9	to	to	TO
en-wikipedia-org-4107	1198	10	exercise	exercise	VB
en-wikipedia-org-4107	1198	11	intervention	intervention	NN
en-wikipedia-org-4107	1198	12	:	:	:
en-wikipedia-org-4107	1198	13	From	from	IN
en-wikipedia-org-4107	1198	14	human	human	NN
en-wikipedia-org-4107	1198	15	to	to	IN
en-wikipedia-org-4107	1198	16	animal	animal	NN
en-wikipedia-org-4107	1198	17	studies	study	NNS
en-wikipedia-org-4107	1198	18	"	"	''
en-wikipedia-org-4107	1198	19	.	.	.
en-wikipedia-org-4107	1199	1	Frontiers	frontier	NNS
en-wikipedia-org-4107	1199	2	in	in	IN
en-wikipedia-org-4107	1199	3	Neuroendocrinology	Neuroendocrinology	NNP
en-wikipedia-org-4107	1199	4	.	.	.
en-wikipedia-org-4107	1200	1	40	40	CD
en-wikipedia-org-4107	1200	2	:	:	:
en-wikipedia-org-4107	1200	3	24–41	24–41	CD
en-wikipedia-org-4107	1200	4	.	.	.
en-wikipedia-org-4107	1201	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1201	2	/	/	SYM
en-wikipedia-org-4107	1201	3	j.yfrne.2015.07.001	j.yfrne.2015.07.001	CD
en-wikipedia-org-4107	1201	4	.	.	.
en-wikipedia-org-4107	1202	1	PMC	PMC	NNP
en-wikipedia-org-4107	1202	2	 	  	_SP
en-wikipedia-org-4107	1202	3	4712120	4712120	CD
en-wikipedia-org-4107	1202	4	.	.	.
en-wikipedia-org-4107	1203	1	PMID	PMID	NNP
en-wikipedia-org-4107	1203	2	 	  	_SP
en-wikipedia-org-4107	1203	3	26182835	26182835	CD
en-wikipedia-org-4107	1203	4	.	.	.
en-wikipedia-org-4107	1204	1	Collectively	collectively	RB
en-wikipedia-org-4107	1204	2	,	,	,
en-wikipedia-org-4107	1204	3	these	these	DT
en-wikipedia-org-4107	1204	4	findings	finding	NNS
en-wikipedia-org-4107	1204	5	demonstrate	demonstrate	VBP
en-wikipedia-org-4107	1204	6	that	that	DT
en-wikipedia-org-4107	1204	7	exercise	exercise	NN
en-wikipedia-org-4107	1204	8	may	may	MD
en-wikipedia-org-4107	1204	9	serve	serve	VB
en-wikipedia-org-4107	1204	10	as	as	IN
en-wikipedia-org-4107	1204	11	a	a	DT
en-wikipedia-org-4107	1204	12	substitute	substitute	NN
en-wikipedia-org-4107	1204	13	or	or	CC
en-wikipedia-org-4107	1204	14	competition	competition	NN
en-wikipedia-org-4107	1204	15	for	for	IN
en-wikipedia-org-4107	1204	16	drug	drug	NN
en-wikipedia-org-4107	1204	17	abuse	abuse	NN
en-wikipedia-org-4107	1204	18	by	by	IN
en-wikipedia-org-4107	1204	19	changing	change	VBG
en-wikipedia-org-4107	1204	20	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1204	21	or	or	CC
en-wikipedia-org-4107	1204	22	cFos	cFos	NNP
en-wikipedia-org-4107	1204	23	immunoreactivity	immunoreactivity	NN
en-wikipedia-org-4107	1204	24	in	in	IN
en-wikipedia-org-4107	1204	25	the	the	DT
en-wikipedia-org-4107	1204	26	reward	reward	NN
en-wikipedia-org-4107	1204	27	system	system	NN
en-wikipedia-org-4107	1204	28	to	to	TO
en-wikipedia-org-4107	1204	29	protect	protect	VB
en-wikipedia-org-4107	1204	30	against	against	IN
en-wikipedia-org-4107	1204	31	later	later	JJ
en-wikipedia-org-4107	1204	32	or	or	CC
en-wikipedia-org-4107	1204	33	previous	previous	JJ
en-wikipedia-org-4107	1204	34	drug	drug	NN
en-wikipedia-org-4107	1204	35	use	use	NN
en-wikipedia-org-4107	1204	36	.	.	.
en-wikipedia-org-4107	1205	1	...	...	NFP
en-wikipedia-org-4107	1206	1	The	the	DT
en-wikipedia-org-4107	1206	2	postulate	postulate	NN
en-wikipedia-org-4107	1206	3	that	that	WDT
en-wikipedia-org-4107	1206	4	exercise	exercise	NN
en-wikipedia-org-4107	1206	5	serves	serve	VBZ
en-wikipedia-org-4107	1206	6	as	as	IN
en-wikipedia-org-4107	1206	7	an	an	DT
en-wikipedia-org-4107	1206	8	ideal	ideal	JJ
en-wikipedia-org-4107	1206	9	intervention	intervention	NN
en-wikipedia-org-4107	1206	10	for	for	IN
en-wikipedia-org-4107	1206	11	drug	drug	NN
en-wikipedia-org-4107	1206	12	addiction	addiction	NN
en-wikipedia-org-4107	1206	13	has	have	VBZ
en-wikipedia-org-4107	1206	14	been	be	VBN
en-wikipedia-org-4107	1206	15	widely	widely	RB
en-wikipedia-org-4107	1206	16	recognized	recognize	VBN
en-wikipedia-org-4107	1206	17	and	and	CC
en-wikipedia-org-4107	1206	18	used	use	VBN
en-wikipedia-org-4107	1206	19	in	in	IN
en-wikipedia-org-4107	1206	20	human	human	JJ
en-wikipedia-org-4107	1206	21	and	and	CC
en-wikipedia-org-4107	1206	22	animal	animal	NN
en-wikipedia-org-4107	1206	23	rehabilitation	rehabilitation	NN
en-wikipedia-org-4107	1206	24	.	.	.
en-wikipedia-org-4107	1207	1	^	^	NNP
en-wikipedia-org-4107	1207	2	a	a	DT
en-wikipedia-org-4107	1207	3	b	b	NNP
en-wikipedia-org-4107	1207	4	c	c	NN
en-wikipedia-org-4107	1207	5	Linke	Linke	NNP
en-wikipedia-org-4107	1207	6	SE	SE	NNP
en-wikipedia-org-4107	1207	7	,	,	,
en-wikipedia-org-4107	1207	8	Ussher	Ussher	NNP
en-wikipedia-org-4107	1207	9	M	M	NNP
en-wikipedia-org-4107	1207	10	(	(	-LRB-
en-wikipedia-org-4107	1207	11	January	January	NNP
en-wikipedia-org-4107	1207	12	2015	2015	CD
en-wikipedia-org-4107	1207	13	)	)	-RRB-
en-wikipedia-org-4107	1207	14	.	.	.
en-wikipedia-org-4107	1208	1	"	"	``
en-wikipedia-org-4107	1208	2	Exercise	exercise	NN
en-wikipedia-org-4107	1208	3	-	-	HYPH
en-wikipedia-org-4107	1208	4	based	base	VBN
en-wikipedia-org-4107	1208	5	treatments	treatment	NNS
en-wikipedia-org-4107	1208	6	for	for	IN
en-wikipedia-org-4107	1208	7	substance	substance	NN
en-wikipedia-org-4107	1208	8	use	use	NN
en-wikipedia-org-4107	1208	9	disorders	disorder	NNS
en-wikipedia-org-4107	1208	10	:	:	:
en-wikipedia-org-4107	1208	11	evidence	evidence	NN
en-wikipedia-org-4107	1208	12	,	,	,
en-wikipedia-org-4107	1208	13	theory	theory	NN
en-wikipedia-org-4107	1208	14	,	,	,
en-wikipedia-org-4107	1208	15	and	and	CC
en-wikipedia-org-4107	1208	16	practicality	practicality	NN
en-wikipedia-org-4107	1208	17	"	"	''
en-wikipedia-org-4107	1208	18	.	.	.
en-wikipedia-org-4107	1209	1	The	the	DT
en-wikipedia-org-4107	1209	2	American	American	NNP
en-wikipedia-org-4107	1209	3	Journal	Journal	NNP
en-wikipedia-org-4107	1209	4	of	of	IN
en-wikipedia-org-4107	1209	5	Drug	Drug	NNP
en-wikipedia-org-4107	1209	6	and	and	CC
en-wikipedia-org-4107	1209	7	Alcohol	Alcohol	NNP
en-wikipedia-org-4107	1209	8	Abuse	Abuse	NNP
en-wikipedia-org-4107	1209	9	.	.	.
en-wikipedia-org-4107	1210	1	41	41	CD
en-wikipedia-org-4107	1210	2	(	(	-LRB-
en-wikipedia-org-4107	1210	3	1	1	CD
en-wikipedia-org-4107	1210	4	)	)	-RRB-
en-wikipedia-org-4107	1210	5	:	:	:
en-wikipedia-org-4107	1210	6	7–15	7–15	NN
en-wikipedia-org-4107	1210	7	.	.	.
en-wikipedia-org-4107	1211	1	doi:10.3109/00952990.2014.976708	doi:10.3109/00952990.2014.976708	NNP
en-wikipedia-org-4107	1211	2	.	.	.
en-wikipedia-org-4107	1212	1	PMC	PMC	NNP
en-wikipedia-org-4107	1212	2	 	  	_SP
en-wikipedia-org-4107	1212	3	4831948	4831948	CD
en-wikipedia-org-4107	1212	4	.	.	.
en-wikipedia-org-4107	1213	1	PMID	PMID	NNP
en-wikipedia-org-4107	1213	2	 	  	_SP
en-wikipedia-org-4107	1213	3	25397661	25397661	CD
en-wikipedia-org-4107	1213	4	.	.	.
en-wikipedia-org-4107	1214	1	The	the	DT
en-wikipedia-org-4107	1214	2	limited	limited	JJ
en-wikipedia-org-4107	1214	3	research	research	NN
en-wikipedia-org-4107	1214	4	conducted	conduct	VBD
en-wikipedia-org-4107	1214	5	suggests	suggest	VBZ
en-wikipedia-org-4107	1214	6	that	that	IN
en-wikipedia-org-4107	1214	7	exercise	exercise	NN
en-wikipedia-org-4107	1214	8	may	may	MD
en-wikipedia-org-4107	1214	9	be	be	VB
en-wikipedia-org-4107	1214	10	an	an	DT
en-wikipedia-org-4107	1214	11	effective	effective	JJ
en-wikipedia-org-4107	1214	12	adjunctive	adjunctive	NN
en-wikipedia-org-4107	1214	13	treatment	treatment	NN
en-wikipedia-org-4107	1214	14	for	for	IN
en-wikipedia-org-4107	1214	15	SUDs	sud	NNS
en-wikipedia-org-4107	1214	16	.	.	.
en-wikipedia-org-4107	1215	1	In	in	IN
en-wikipedia-org-4107	1215	2	contrast	contrast	NN
en-wikipedia-org-4107	1215	3	to	to	IN
en-wikipedia-org-4107	1215	4	the	the	DT
en-wikipedia-org-4107	1215	5	scarce	scarce	JJ
en-wikipedia-org-4107	1215	6	intervention	intervention	NN
en-wikipedia-org-4107	1215	7	trials	trial	NNS
en-wikipedia-org-4107	1215	8	to	to	IN
en-wikipedia-org-4107	1215	9	date	date	NN
en-wikipedia-org-4107	1215	10	,	,	,
en-wikipedia-org-4107	1215	11	a	a	DT
en-wikipedia-org-4107	1215	12	relative	relative	JJ
en-wikipedia-org-4107	1215	13	abundance	abundance	NN
en-wikipedia-org-4107	1215	14	of	of	IN
en-wikipedia-org-4107	1215	15	literature	literature	NN
en-wikipedia-org-4107	1215	16	on	on	IN
en-wikipedia-org-4107	1215	17	the	the	DT
en-wikipedia-org-4107	1215	18	theoretical	theoretical	JJ
en-wikipedia-org-4107	1215	19	and	and	CC
en-wikipedia-org-4107	1215	20	practical	practical	JJ
en-wikipedia-org-4107	1215	21	reasons	reason	NNS
en-wikipedia-org-4107	1215	22	supporting	support	VBG
en-wikipedia-org-4107	1215	23	the	the	DT
en-wikipedia-org-4107	1215	24	investigation	investigation	NN
en-wikipedia-org-4107	1215	25	of	of	IN
en-wikipedia-org-4107	1215	26	this	this	DT
en-wikipedia-org-4107	1215	27	topic	topic	NN
en-wikipedia-org-4107	1215	28	has	have	VBZ
en-wikipedia-org-4107	1215	29	been	be	VBN
en-wikipedia-org-4107	1215	30	published	publish	VBN
en-wikipedia-org-4107	1215	31	.	.	.
en-wikipedia-org-4107	1216	1	...	...	:
en-wikipedia-org-4107	1216	2	numerous	numerous	JJ
en-wikipedia-org-4107	1216	3	theoretical	theoretical	JJ
en-wikipedia-org-4107	1216	4	and	and	CC
en-wikipedia-org-4107	1216	5	practical	practical	JJ
en-wikipedia-org-4107	1216	6	reasons	reason	NNS
en-wikipedia-org-4107	1216	7	support	support	VBP
en-wikipedia-org-4107	1216	8	exercise	exercise	NN
en-wikipedia-org-4107	1216	9	-	-	HYPH
en-wikipedia-org-4107	1216	10	based	base	VBN
en-wikipedia-org-4107	1216	11	treatments	treatment	NNS
en-wikipedia-org-4107	1216	12	for	for	IN
en-wikipedia-org-4107	1216	13	SUDs	SUDs	NNPS
en-wikipedia-org-4107	1216	14	,	,	,
en-wikipedia-org-4107	1216	15	including	include	VBG
en-wikipedia-org-4107	1216	16	psychological	psychological	JJ
en-wikipedia-org-4107	1216	17	,	,	,
en-wikipedia-org-4107	1216	18	behavioral	behavioral	JJ
en-wikipedia-org-4107	1216	19	,	,	,
en-wikipedia-org-4107	1216	20	neurobiological	neurobiological	JJ
en-wikipedia-org-4107	1216	21	,	,	,
en-wikipedia-org-4107	1216	22	nearly	nearly	RB
en-wikipedia-org-4107	1216	23	universal	universal	JJ
en-wikipedia-org-4107	1216	24	safety	safety	NN
en-wikipedia-org-4107	1216	25	profile	profile	NN
en-wikipedia-org-4107	1216	26	,	,	,
en-wikipedia-org-4107	1216	27	and	and	CC
en-wikipedia-org-4107	1216	28	overall	overall	JJ
en-wikipedia-org-4107	1216	29	positive	positive	JJ
en-wikipedia-org-4107	1216	30	health	health	NN
en-wikipedia-org-4107	1216	31	effects	effect	NNS
en-wikipedia-org-4107	1216	32	.	.	.
en-wikipedia-org-4107	1217	1	^	^	NNP
en-wikipedia-org-4107	1217	2	Hyman	Hyman	NNP
en-wikipedia-org-4107	1217	3	SE	SE	NNP
en-wikipedia-org-4107	1217	4	,	,	,
en-wikipedia-org-4107	1217	5	Malenka	Malenka	NNP
en-wikipedia-org-4107	1217	6	RC	RC	NNP
en-wikipedia-org-4107	1217	7	,	,	,
en-wikipedia-org-4107	1217	8	Nestler	Nestler	NNP
en-wikipedia-org-4107	1217	9	EJ	EJ	NNP
en-wikipedia-org-4107	1217	10	(	(	-LRB-
en-wikipedia-org-4107	1217	11	July	July	NNP
en-wikipedia-org-4107	1217	12	2006	2006	CD
en-wikipedia-org-4107	1217	13	)	)	-RRB-
en-wikipedia-org-4107	1217	14	.	.	.
en-wikipedia-org-4107	1218	1	"	"	``
en-wikipedia-org-4107	1218	2	Neural	neural	JJ
en-wikipedia-org-4107	1218	3	mechanisms	mechanism	NNS
en-wikipedia-org-4107	1218	4	of	of	IN
en-wikipedia-org-4107	1218	5	addiction	addiction	NN
en-wikipedia-org-4107	1218	6	:	:	:
en-wikipedia-org-4107	1218	7	the	the	DT
en-wikipedia-org-4107	1218	8	role	role	NN
en-wikipedia-org-4107	1218	9	of	of	IN
en-wikipedia-org-4107	1218	10	reward	reward	NN
en-wikipedia-org-4107	1218	11	-	-	HYPH
en-wikipedia-org-4107	1218	12	related	relate	VBN
en-wikipedia-org-4107	1218	13	learning	learning	NN
en-wikipedia-org-4107	1218	14	and	and	CC
en-wikipedia-org-4107	1218	15	memory	memory	NN
en-wikipedia-org-4107	1218	16	"	"	''
en-wikipedia-org-4107	1218	17	(	(	-LRB-
en-wikipedia-org-4107	1218	18	PDF	PDF	NNP
en-wikipedia-org-4107	1218	19	)	)	-RRB-
en-wikipedia-org-4107	1218	20	.	.	.
en-wikipedia-org-4107	1219	1	Annual	Annual	NNP
en-wikipedia-org-4107	1219	2	Review	Review	NNP
en-wikipedia-org-4107	1219	3	of	of	IN
en-wikipedia-org-4107	1219	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1219	5	.	.	.
en-wikipedia-org-4107	1220	1	29	29	CD
en-wikipedia-org-4107	1220	2	:	:	:
en-wikipedia-org-4107	1220	3	565–598	565–598	CD
en-wikipedia-org-4107	1220	4	.	.	.
en-wikipedia-org-4107	1221	1	doi:10.1146	doi:10.1146	NNP
en-wikipedia-org-4107	1221	2	/	/	SYM
en-wikipedia-org-4107	1221	3	annurev.neuro.29.051605.113009	annurev.neuro.29.051605.113009	NNP
en-wikipedia-org-4107	1221	4	.	.	.
en-wikipedia-org-4107	1222	1	PMID	PMID	NNP
en-wikipedia-org-4107	1222	2	 	  	_SP
en-wikipedia-org-4107	1222	3	16776597	16776597	CD
en-wikipedia-org-4107	1222	4	.	.	.
en-wikipedia-org-4107	1223	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1223	2	 	  	_SP
en-wikipedia-org-4107	1223	3	15139406	15139406	CD
en-wikipedia-org-4107	1223	4	.	.	.
en-wikipedia-org-4107	1224	1	^	^	NNP
en-wikipedia-org-4107	1224	2	a	a	DT
en-wikipedia-org-4107	1224	3	b	b	NNP
en-wikipedia-org-4107	1224	4	c	c	NN
en-wikipedia-org-4107	1224	5	d	d	NN
en-wikipedia-org-4107	1224	6	e	e	NN
en-wikipedia-org-4107	1224	7	Steiner	Steiner	NNP
en-wikipedia-org-4107	1224	8	H	H	NNP
en-wikipedia-org-4107	1224	9	,	,	,
en-wikipedia-org-4107	1224	10	Van	Van	NNP
en-wikipedia-org-4107	1224	11	Waes	Waes	NNP
en-wikipedia-org-4107	1224	12	V	V	NNP
en-wikipedia-org-4107	1224	13	(	(	-LRB-
en-wikipedia-org-4107	1224	14	January	January	NNP
en-wikipedia-org-4107	1224	15	2013	2013	CD
en-wikipedia-org-4107	1224	16	)	)	-RRB-
en-wikipedia-org-4107	1224	17	.	.	.
en-wikipedia-org-4107	1225	1	"	"	``
en-wikipedia-org-4107	1225	2	Addiction	addiction	NN
en-wikipedia-org-4107	1225	3	-	-	HYPH
en-wikipedia-org-4107	1225	4	related	relate	VBN
en-wikipedia-org-4107	1225	5	gene	gene	NN
en-wikipedia-org-4107	1225	6	regulation	regulation	NN
en-wikipedia-org-4107	1225	7	:	:	:
en-wikipedia-org-4107	1225	8	risks	risk	NNS
en-wikipedia-org-4107	1225	9	of	of	IN
en-wikipedia-org-4107	1225	10	exposure	exposure	NN
en-wikipedia-org-4107	1225	11	to	to	IN
en-wikipedia-org-4107	1225	12	cognitive	cognitive	JJ
en-wikipedia-org-4107	1225	13	enhancers	enhancer	NNS
en-wikipedia-org-4107	1225	14	vs.	vs.	IN
en-wikipedia-org-4107	1225	15	other	other	JJ
en-wikipedia-org-4107	1225	16	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	1225	17	"	"	''
en-wikipedia-org-4107	1225	18	.	.	.
en-wikipedia-org-4107	1226	1	Progress	progress	NN
en-wikipedia-org-4107	1226	2	in	in	IN
en-wikipedia-org-4107	1226	3	Neurobiology	Neurobiology	NNP
en-wikipedia-org-4107	1226	4	.	.	.
en-wikipedia-org-4107	1227	1	100	100	CD
en-wikipedia-org-4107	1227	2	:	:	:
en-wikipedia-org-4107	1227	3	60–80	60–80	CD
en-wikipedia-org-4107	1227	4	.	.	.
en-wikipedia-org-4107	1228	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1228	2	/	/	SYM
en-wikipedia-org-4107	1228	3	j.pneurobio.2012.10.001	j.pneurobio.2012.10.001	NN
en-wikipedia-org-4107	1228	4	.	.	.
en-wikipedia-org-4107	1229	1	PMC	PMC	NNP
en-wikipedia-org-4107	1229	2	 	  	_SP
en-wikipedia-org-4107	1229	3	3525776	3525776	CD
en-wikipedia-org-4107	1229	4	.	.	.
en-wikipedia-org-4107	1230	1	PMID	PMID	NNP
en-wikipedia-org-4107	1230	2	 	  	_SP
en-wikipedia-org-4107	1230	3	23085425	23085425	CD
en-wikipedia-org-4107	1230	4	.	.	.
en-wikipedia-org-4107	1231	1	^	^	NNP
en-wikipedia-org-4107	1231	2	Malenka	Malenka	NNP
en-wikipedia-org-4107	1231	3	RC	RC	NNP
en-wikipedia-org-4107	1231	4	,	,	,
en-wikipedia-org-4107	1231	5	Nestler	Nestler	NNP
en-wikipedia-org-4107	1231	6	EJ	EJ	NNP
en-wikipedia-org-4107	1231	7	,	,	,
en-wikipedia-org-4107	1231	8	Hyman	Hyman	NNP
en-wikipedia-org-4107	1231	9	SE	SE	NNP
en-wikipedia-org-4107	1231	10	(	(	-LRB-
en-wikipedia-org-4107	1231	11	2009	2009	CD
en-wikipedia-org-4107	1231	12	)	)	-RRB-
en-wikipedia-org-4107	1231	13	.	.	.
en-wikipedia-org-4107	1232	1	"	"	``
en-wikipedia-org-4107	1232	2	Chapter	chapter	NN
en-wikipedia-org-4107	1232	3	4	4	CD
en-wikipedia-org-4107	1232	4	:	:	:
en-wikipedia-org-4107	1232	5	Signal	Signal	NNP
en-wikipedia-org-4107	1232	6	Transduction	Transduction	NNP
en-wikipedia-org-4107	1232	7	in	in	IN
en-wikipedia-org-4107	1232	8	the	the	DT
en-wikipedia-org-4107	1232	9	Brain	Brain	NNP
en-wikipedia-org-4107	1232	10	"	"	''
en-wikipedia-org-4107	1232	11	.	.	.
en-wikipedia-org-4107	1233	1	In	in	IN
en-wikipedia-org-4107	1233	2	Sydor	Sydor	NNP
en-wikipedia-org-4107	1233	3	A	A	NNP
en-wikipedia-org-4107	1233	4	,	,	,
en-wikipedia-org-4107	1233	5	Brown	Brown	NNP
en-wikipedia-org-4107	1233	6	RY	RY	NNP
en-wikipedia-org-4107	1233	7	(	(	-LRB-
en-wikipedia-org-4107	1233	8	eds	eds	NNP
en-wikipedia-org-4107	1233	9	.	.	.
en-wikipedia-org-4107	1233	10	)	)	-RRB-
en-wikipedia-org-4107	1233	11	.	.	.
en-wikipedia-org-4107	1234	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	1234	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-4107	1234	3	:	:	:
en-wikipedia-org-4107	1234	4	A	A	NNP
en-wikipedia-org-4107	1234	5	Foundation	Foundation	NNP
en-wikipedia-org-4107	1234	6	for	for	IN
en-wikipedia-org-4107	1234	7	Clinical	Clinical	NNP
en-wikipedia-org-4107	1234	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1234	9	(	(	-LRB-
en-wikipedia-org-4107	1234	10	2nd	2nd	NNP
en-wikipedia-org-4107	1234	11	ed	ed	NNP
en-wikipedia-org-4107	1234	12	.	.	.
en-wikipedia-org-4107	1234	13	)	)	-RRB-
en-wikipedia-org-4107	1234	14	.	.	.
en-wikipedia-org-4107	1235	1	New	New	NNP
en-wikipedia-org-4107	1235	2	York	York	NNP
en-wikipedia-org-4107	1235	3	,	,	,
en-wikipedia-org-4107	1235	4	USA	USA	NNP
en-wikipedia-org-4107	1235	5	:	:	:
en-wikipedia-org-4107	1235	6	McGraw	McGraw	NNP
en-wikipedia-org-4107	1235	7	-	-	HYPH
en-wikipedia-org-4107	1235	8	Hill	Hill	NNP
en-wikipedia-org-4107	1235	9	Medical	Medical	NNP
en-wikipedia-org-4107	1235	10	.	.	.
en-wikipedia-org-4107	1236	1	p.	p.	NN
en-wikipedia-org-4107	1236	2	 	  	_SP
en-wikipedia-org-4107	1236	3	94	94	CD
en-wikipedia-org-4107	1236	4	.	.	.
en-wikipedia-org-4107	1237	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	1237	2	 	  	_SP
en-wikipedia-org-4107	1237	3	9780071481274	9780071481274	CD
en-wikipedia-org-4107	1237	4	.	.	.
en-wikipedia-org-4107	1238	1	^	^	NNP
en-wikipedia-org-4107	1238	2	Kanehisa	Kanehisa	NNP
en-wikipedia-org-4107	1238	3	Laboratories	Laboratories	NNP
en-wikipedia-org-4107	1238	4	(	(	-LRB-
en-wikipedia-org-4107	1238	5	29	29	CD
en-wikipedia-org-4107	1238	6	October	October	NNP
en-wikipedia-org-4107	1238	7	2014	2014	CD
en-wikipedia-org-4107	1238	8	)	)	-RRB-
en-wikipedia-org-4107	1238	9	.	.	.
en-wikipedia-org-4107	1239	1	"	"	``
en-wikipedia-org-4107	1239	2	Alcoholism	alcoholism	NN
en-wikipedia-org-4107	1239	3	–	–	:
en-wikipedia-org-4107	1239	4	Homo	Homo	NNP
en-wikipedia-org-4107	1239	5	sapiens	sapiens	JJ
en-wikipedia-org-4107	1239	6	(	(	-LRB-
en-wikipedia-org-4107	1239	7	human	human	JJ
en-wikipedia-org-4107	1239	8	)	)	-RRB-
en-wikipedia-org-4107	1239	9	"	"	''
en-wikipedia-org-4107	1239	10	.	.	.
en-wikipedia-org-4107	1240	1	KEGG	KEGG	NNP
en-wikipedia-org-4107	1240	2	Pathway	Pathway	NNP
en-wikipedia-org-4107	1240	3	.	.	.
en-wikipedia-org-4107	1241	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1241	2	31	31	CD
en-wikipedia-org-4107	1241	3	October	October	NNP
en-wikipedia-org-4107	1241	4	2014	2014	CD
en-wikipedia-org-4107	1241	5	.	.	.
en-wikipedia-org-4107	1242	1	^	^	NFP
en-wikipedia-org-4107	1242	2	Kim	Kim	NNP
en-wikipedia-org-4107	1242	3	Y	Y	NNP
en-wikipedia-org-4107	1242	4	,	,	,
en-wikipedia-org-4107	1242	5	Teylan	Teylan	NNP
en-wikipedia-org-4107	1242	6	MA	MA	NNP
en-wikipedia-org-4107	1242	7	,	,	,
en-wikipedia-org-4107	1242	8	Baron	Baron	NNP
en-wikipedia-org-4107	1242	9	M	M	NNP
en-wikipedia-org-4107	1242	10	,	,	,
en-wikipedia-org-4107	1242	11	Sands	sand	VBZ
en-wikipedia-org-4107	1242	12	A	a	DT
en-wikipedia-org-4107	1242	13	,	,	,
en-wikipedia-org-4107	1242	14	Nairn	Nairn	NNP
en-wikipedia-org-4107	1242	15	AC	AC	NNP
en-wikipedia-org-4107	1242	16	,	,	,
en-wikipedia-org-4107	1242	17	Greengard	Greengard	NNP
en-wikipedia-org-4107	1242	18	P	P	NNP
en-wikipedia-org-4107	1242	19	(	(	-LRB-
en-wikipedia-org-4107	1242	20	February	February	NNP
en-wikipedia-org-4107	1242	21	2009	2009	CD
en-wikipedia-org-4107	1242	22	)	)	-RRB-
en-wikipedia-org-4107	1242	23	.	.	.
en-wikipedia-org-4107	1243	1	"	"	``
en-wikipedia-org-4107	1243	2	Methylphenidate	methylphenidate	NN
en-wikipedia-org-4107	1243	3	-	-	HYPH
en-wikipedia-org-4107	1243	4	induced	induce	VBN
en-wikipedia-org-4107	1243	5	dendritic	dendritic	JJ
en-wikipedia-org-4107	1243	6	spine	spine	NN
en-wikipedia-org-4107	1243	7	formation	formation	NN
en-wikipedia-org-4107	1243	8	and	and	CC
en-wikipedia-org-4107	1243	9	DeltaFosB	DeltaFosB	VBD
en-wikipedia-org-4107	1243	10	expression	expression	NN
en-wikipedia-org-4107	1243	11	in	in	IN
en-wikipedia-org-4107	1243	12	nucleus	nucleus	NNP
en-wikipedia-org-4107	1243	13	accumbens	accumben	NNS
en-wikipedia-org-4107	1243	14	"	"	''
en-wikipedia-org-4107	1243	15	.	.	.
en-wikipedia-org-4107	1244	1	Proceedings	proceeding	NNS
en-wikipedia-org-4107	1244	2	of	of	IN
en-wikipedia-org-4107	1244	3	the	the	DT
en-wikipedia-org-4107	1244	4	National	National	NNP
en-wikipedia-org-4107	1244	5	Academy	Academy	NNP
en-wikipedia-org-4107	1244	6	of	of	IN
en-wikipedia-org-4107	1244	7	Sciences	Sciences	NNPS
en-wikipedia-org-4107	1244	8	.	.	.
en-wikipedia-org-4107	1245	1	106	106	CD
en-wikipedia-org-4107	1245	2	(	(	-LRB-
en-wikipedia-org-4107	1245	3	8)	8)	CD
en-wikipedia-org-4107	1245	4	:	:	:
en-wikipedia-org-4107	1245	5	2915–2920	2915–2920	CD
en-wikipedia-org-4107	1245	6	.	.	.
en-wikipedia-org-4107	1246	1	Bibcode:2009PNAS	bibcode:2009pnas	UH
en-wikipedia-org-4107	1246	2	..	..	NFP
en-wikipedia-org-4107	1246	3	106.2915K.	106.2915k.	CD
en-wikipedia-org-4107	1247	1	doi:10.1073	doi:10.1073	NNP
en-wikipedia-org-4107	1247	2	/	/	SYM
en-wikipedia-org-4107	1247	3	pnas.0813179106	pnas.0813179106	NNP
en-wikipedia-org-4107	1247	4	.	.	.
en-wikipedia-org-4107	1248	1	PMC	PMC	NNP
en-wikipedia-org-4107	1248	2	 	  	_SP
en-wikipedia-org-4107	1248	3	2650365	2650365	CD
en-wikipedia-org-4107	1248	4	.	.	.
en-wikipedia-org-4107	1249	1	PMID	PMID	NNP
en-wikipedia-org-4107	1249	2	 	  	_SP
en-wikipedia-org-4107	1249	3	19202072	19202072	CD
en-wikipedia-org-4107	1249	4	.	.	.
en-wikipedia-org-4107	1250	1	^	^	NNP
en-wikipedia-org-4107	1250	2	a	a	DT
en-wikipedia-org-4107	1250	3	b	b	NNP
en-wikipedia-org-4107	1250	4	Nestler	Nestler	NNP
en-wikipedia-org-4107	1250	5	EJ	EJ	NNP
en-wikipedia-org-4107	1250	6	(	(	-LRB-
en-wikipedia-org-4107	1250	7	January	January	NNP
en-wikipedia-org-4107	1250	8	2014	2014	CD
en-wikipedia-org-4107	1250	9	)	)	-RRB-
en-wikipedia-org-4107	1250	10	.	.	.
en-wikipedia-org-4107	1251	1	"	"	``
en-wikipedia-org-4107	1251	2	Epigenetic	epigenetic	JJ
en-wikipedia-org-4107	1251	3	mechanisms	mechanism	NNS
en-wikipedia-org-4107	1251	4	of	of	IN
en-wikipedia-org-4107	1251	5	drug	drug	NN
en-wikipedia-org-4107	1251	6	addiction	addiction	NN
en-wikipedia-org-4107	1251	7	"	"	''
en-wikipedia-org-4107	1251	8	.	.	.
en-wikipedia-org-4107	1252	1	Neuropharmacology	neuropharmacology	NN
en-wikipedia-org-4107	1252	2	.	.	.
en-wikipedia-org-4107	1253	1	76	76	CD
en-wikipedia-org-4107	1253	2	Pt	Pt	NNP
en-wikipedia-org-4107	1253	3	B	B	NNP
en-wikipedia-org-4107	1253	4	:	:	:
en-wikipedia-org-4107	1253	5	259–268	259–268	CD
en-wikipedia-org-4107	1253	6	.	.	.
en-wikipedia-org-4107	1254	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1254	2	/	/	SYM
en-wikipedia-org-4107	1254	3	j.neuropharm.2013.04.004	j.neuropharm.2013.04.004	NN
en-wikipedia-org-4107	1254	4	.	.	.
en-wikipedia-org-4107	1255	1	PMC	PMC	NNP
en-wikipedia-org-4107	1255	2	 	  	_SP
en-wikipedia-org-4107	1255	3	3766384	3766384	CD
en-wikipedia-org-4107	1255	4	.	.	.
en-wikipedia-org-4107	1256	1	PMID	PMID	NNP
en-wikipedia-org-4107	1256	2	 	  	_SP
en-wikipedia-org-4107	1256	3	23643695	23643695	CD
en-wikipedia-org-4107	1256	4	.	.	.
en-wikipedia-org-4107	1257	1	^	^	NNP
en-wikipedia-org-4107	1257	2	a	a	DT
en-wikipedia-org-4107	1257	3	b	b	NN
en-wikipedia-org-4107	1257	4	Biliński	Biliński	NNP
en-wikipedia-org-4107	1257	5	P	P	NNP
en-wikipedia-org-4107	1257	6	,	,	,
en-wikipedia-org-4107	1257	7	Wojtyła	Wojtyła	NNP
en-wikipedia-org-4107	1257	8	A	A	NNP
en-wikipedia-org-4107	1257	9	,	,	,
en-wikipedia-org-4107	1257	10	Kapka	Kapka	NNP
en-wikipedia-org-4107	1257	11	-	-	HYPH
en-wikipedia-org-4107	1257	12	Skrzypczak	Skrzypczak	NNP
en-wikipedia-org-4107	1257	13	L	L	NNP
en-wikipedia-org-4107	1257	14	,	,	,
en-wikipedia-org-4107	1257	15	Chwedorowicz	Chwedorowicz	NNP
en-wikipedia-org-4107	1257	16	R	R	NNP
en-wikipedia-org-4107	1257	17	,	,	,
en-wikipedia-org-4107	1257	18	Cyranka	Cyranka	NNP
en-wikipedia-org-4107	1257	19	M	M	NNP
en-wikipedia-org-4107	1257	20	,	,	,
en-wikipedia-org-4107	1257	21	Studziński	Studziński	NNP
en-wikipedia-org-4107	1257	22	T	T	NNP
en-wikipedia-org-4107	1257	23	(	(	-LRB-
en-wikipedia-org-4107	1257	24	2012	2012	CD
en-wikipedia-org-4107	1257	25	)	)	-RRB-
en-wikipedia-org-4107	1257	26	.	.	.
en-wikipedia-org-4107	1258	1	"	"	``
en-wikipedia-org-4107	1258	2	Epigenetic	epigenetic	JJ
en-wikipedia-org-4107	1258	3	regulation	regulation	NN
en-wikipedia-org-4107	1258	4	in	in	IN
en-wikipedia-org-4107	1258	5	drug	drug	NN
en-wikipedia-org-4107	1258	6	addiction	addiction	NN
en-wikipedia-org-4107	1258	7	"	"	''
en-wikipedia-org-4107	1258	8	.	.	.
en-wikipedia-org-4107	1259	1	Annals	Annals	NNP
en-wikipedia-org-4107	1259	2	of	of	IN
en-wikipedia-org-4107	1259	3	Agricultural	Agricultural	NNP
en-wikipedia-org-4107	1259	4	and	and	CC
en-wikipedia-org-4107	1259	5	Environmental	Environmental	NNP
en-wikipedia-org-4107	1259	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	1259	7	.	.	.
en-wikipedia-org-4107	1260	1	19	19	CD
en-wikipedia-org-4107	1260	2	(	(	-LRB-
en-wikipedia-org-4107	1260	3	3	3	CD
en-wikipedia-org-4107	1260	4	)	)	-RRB-
en-wikipedia-org-4107	1260	5	:	:	:
en-wikipedia-org-4107	1260	6	491–496	491–496	CD
en-wikipedia-org-4107	1260	7	.	.	.
en-wikipedia-org-4107	1261	1	PMID	PMID	NNP
en-wikipedia-org-4107	1261	2	 	  	_SP
en-wikipedia-org-4107	1261	3	23020045	23020045	CD
en-wikipedia-org-4107	1261	4	.	.	.
en-wikipedia-org-4107	1262	1	^	^	NNP
en-wikipedia-org-4107	1262	2	Kennedy	Kennedy	NNP
en-wikipedia-org-4107	1262	3	PJ	PJ	NNP
en-wikipedia-org-4107	1262	4	,	,	,
en-wikipedia-org-4107	1262	5	Feng	Feng	NNP
en-wikipedia-org-4107	1262	6	J	J	NNP
en-wikipedia-org-4107	1262	7	,	,	,
en-wikipedia-org-4107	1262	8	Robison	Robison	NNP
en-wikipedia-org-4107	1262	9	AJ	AJ	NNP
en-wikipedia-org-4107	1262	10	,	,	,
en-wikipedia-org-4107	1262	11	Maze	Maze	NNP
en-wikipedia-org-4107	1262	12	I	-PRON-	PRP
en-wikipedia-org-4107	1262	13	,	,	,
en-wikipedia-org-4107	1262	14	Badimon	Badimon	NNP
en-wikipedia-org-4107	1262	15	A	A	NNP
en-wikipedia-org-4107	1262	16	,	,	,
en-wikipedia-org-4107	1262	17	Mouzon	Mouzon	NNP
en-wikipedia-org-4107	1262	18	E	E	NNP
en-wikipedia-org-4107	1262	19	,	,	,
en-wikipedia-org-4107	1262	20	Chaudhury	Chaudhury	NNP
en-wikipedia-org-4107	1262	21	D	D	NNP
en-wikipedia-org-4107	1262	22	,	,	,
en-wikipedia-org-4107	1262	23	Damez	Damez	NNP
en-wikipedia-org-4107	1262	24	-	-	HYPH
en-wikipedia-org-4107	1262	25	Werno	Werno	NNP
en-wikipedia-org-4107	1262	26	DM	DM	NNP
en-wikipedia-org-4107	1262	27	,	,	,
en-wikipedia-org-4107	1262	28	Haggarty	Haggarty	NNP
en-wikipedia-org-4107	1262	29	SJ	SJ	NNP
en-wikipedia-org-4107	1262	30	,	,	,
en-wikipedia-org-4107	1262	31	Han	Han	NNP
en-wikipedia-org-4107	1262	32	MH	MH	NNP
en-wikipedia-org-4107	1262	33	,	,	,
en-wikipedia-org-4107	1262	34	Bassel	Bassel	NNP
en-wikipedia-org-4107	1262	35	-	-	HYPH
en-wikipedia-org-4107	1262	36	Duby	Duby	NNP
en-wikipedia-org-4107	1262	37	R	R	NNP
en-wikipedia-org-4107	1262	38	,	,	,
en-wikipedia-org-4107	1262	39	Olson	Olson	NNP
en-wikipedia-org-4107	1262	40	EN	EN	NNP
en-wikipedia-org-4107	1262	41	,	,	,
en-wikipedia-org-4107	1262	42	Nestler	Nestler	NNP
en-wikipedia-org-4107	1262	43	EJ	EJ	NNP
en-wikipedia-org-4107	1262	44	(	(	-LRB-
en-wikipedia-org-4107	1262	45	April	April	NNP
en-wikipedia-org-4107	1262	46	2013	2013	CD
en-wikipedia-org-4107	1262	47	)	)	-RRB-
en-wikipedia-org-4107	1262	48	.	.	.
en-wikipedia-org-4107	1263	1	"	"	``
en-wikipedia-org-4107	1263	2	Class	class	NN
en-wikipedia-org-4107	1263	3	I	-PRON-	PRP
en-wikipedia-org-4107	1263	4	HDAC	hdac	VBP
en-wikipedia-org-4107	1263	5	inhibition	inhibition	NN
en-wikipedia-org-4107	1263	6	blocks	block	VBZ
en-wikipedia-org-4107	1263	7	cocaine	cocaine	NN
en-wikipedia-org-4107	1263	8	-	-	HYPH
en-wikipedia-org-4107	1263	9	induced	induce	VBN
en-wikipedia-org-4107	1263	10	plasticity	plasticity	NN
en-wikipedia-org-4107	1263	11	by	by	IN
en-wikipedia-org-4107	1263	12	targeted	target	VBN
en-wikipedia-org-4107	1263	13	changes	change	NNS
en-wikipedia-org-4107	1263	14	in	in	IN
en-wikipedia-org-4107	1263	15	histone	histone	JJ
en-wikipedia-org-4107	1263	16	methylation	methylation	NN
en-wikipedia-org-4107	1263	17	"	"	''
en-wikipedia-org-4107	1263	18	.	.	.
en-wikipedia-org-4107	1264	1	Nature	nature	NN
en-wikipedia-org-4107	1264	2	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1264	3	.	.	.
en-wikipedia-org-4107	1265	1	16	16	CD
en-wikipedia-org-4107	1265	2	(	(	-LRB-
en-wikipedia-org-4107	1265	3	4	4	CD
en-wikipedia-org-4107	1265	4	)	)	-RRB-
en-wikipedia-org-4107	1265	5	:	:	:
en-wikipedia-org-4107	1265	6	434–440	434–440	CD
en-wikipedia-org-4107	1265	7	.	.	.
en-wikipedia-org-4107	1266	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-4107	1266	2	/	/	SYM
en-wikipedia-org-4107	1266	3	nn.3354	nn.3354	NNP
en-wikipedia-org-4107	1266	4	.	.	.
en-wikipedia-org-4107	1267	1	PMC	PMC	NNP
en-wikipedia-org-4107	1267	2	 	  	_SP
en-wikipedia-org-4107	1267	3	3609040	3609040	CD
en-wikipedia-org-4107	1267	4	.	.	.
en-wikipedia-org-4107	1268	1	PMID	PMID	NNP
en-wikipedia-org-4107	1268	2	 	  	_SP
en-wikipedia-org-4107	1268	3	23475113	23475113	CD
en-wikipedia-org-4107	1268	4	.	.	.
en-wikipedia-org-4107	1269	1	^	^	NNP
en-wikipedia-org-4107	1269	2	Whalley	Whalley	NNP
en-wikipedia-org-4107	1269	3	K	K	NNP
en-wikipedia-org-4107	1269	4	(	(	-LRB-
en-wikipedia-org-4107	1269	5	December	December	NNP
en-wikipedia-org-4107	1269	6	2014	2014	CD
en-wikipedia-org-4107	1269	7	)	)	-RRB-
en-wikipedia-org-4107	1269	8	.	.	.
en-wikipedia-org-4107	1270	1	"	"	``
en-wikipedia-org-4107	1270	2	Psychiatric	psychiatric	JJ
en-wikipedia-org-4107	1270	3	disorders	disorder	NNS
en-wikipedia-org-4107	1270	4	:	:	:
en-wikipedia-org-4107	1270	5	a	a	DT
en-wikipedia-org-4107	1270	6	feat	feat	NN
en-wikipedia-org-4107	1270	7	of	of	IN
en-wikipedia-org-4107	1270	8	epigenetic	epigenetic	JJ
en-wikipedia-org-4107	1270	9	engineering	engineering	NN
en-wikipedia-org-4107	1270	10	"	"	''
en-wikipedia-org-4107	1270	11	.	.	.
en-wikipedia-org-4107	1271	1	Nature	Nature	NNP
en-wikipedia-org-4107	1271	2	Reviews	Reviews	NNPS
en-wikipedia-org-4107	1271	3	.	.	.
en-wikipedia-org-4107	1272	1	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1272	2	.	.	.
en-wikipedia-org-4107	1273	1	15	15	CD
en-wikipedia-org-4107	1273	2	(	(	-LRB-
en-wikipedia-org-4107	1273	3	12	12	CD
en-wikipedia-org-4107	1273	4	)	)	-RRB-
en-wikipedia-org-4107	1273	5	:	:	:
en-wikipedia-org-4107	1273	6	768–769	768–769	CD
en-wikipedia-org-4107	1273	7	.	.	.
en-wikipedia-org-4107	1274	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-4107	1274	2	/	/	SYM
en-wikipedia-org-4107	1274	3	nrn3869	nrn3869	NNP
en-wikipedia-org-4107	1274	4	.	.	.
en-wikipedia-org-4107	1275	1	PMID	PMID	NNP
en-wikipedia-org-4107	1275	2	 	  	_SP
en-wikipedia-org-4107	1275	3	25409693	25409693	CD
en-wikipedia-org-4107	1275	4	.	.	.
en-wikipedia-org-4107	1276	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1276	2	 	  	_SP
en-wikipedia-org-4107	1276	3	11513288	11513288	CD
en-wikipedia-org-4107	1276	4	.	.	.
en-wikipedia-org-4107	1277	1	^	^	NNP
en-wikipedia-org-4107	1277	2	a	a	DT
en-wikipedia-org-4107	1277	3	b	b	NN
en-wikipedia-org-4107	1277	4	Blum	Blum	NNP
en-wikipedia-org-4107	1277	5	K	K	NNP
en-wikipedia-org-4107	1277	6	,	,	,
en-wikipedia-org-4107	1277	7	Werner	Werner	NNP
en-wikipedia-org-4107	1277	8	T	T	NNP
en-wikipedia-org-4107	1277	9	,	,	,
en-wikipedia-org-4107	1277	10	Carnes	Carnes	NNP
en-wikipedia-org-4107	1277	11	S	S	NNP
en-wikipedia-org-4107	1277	12	,	,	,
en-wikipedia-org-4107	1277	13	Carnes	Carnes	NNP
en-wikipedia-org-4107	1277	14	P	P	NNP
en-wikipedia-org-4107	1277	15	,	,	,
en-wikipedia-org-4107	1277	16	Bowirrat	Bowirrat	NNP
en-wikipedia-org-4107	1277	17	A	A	NNP
en-wikipedia-org-4107	1277	18	,	,	,
en-wikipedia-org-4107	1277	19	Giordano	Giordano	NNP
en-wikipedia-org-4107	1277	20	J	J	NNP
en-wikipedia-org-4107	1277	21	,	,	,
en-wikipedia-org-4107	1277	22	Oscar	Oscar	NNP
en-wikipedia-org-4107	1277	23	-	-	HYPH
en-wikipedia-org-4107	1277	24	Berman	Berman	NNP
en-wikipedia-org-4107	1277	25	M	M	NNP
en-wikipedia-org-4107	1277	26	,	,	,
en-wikipedia-org-4107	1277	27	Gold	Gold	NNP
en-wikipedia-org-4107	1277	28	M	M	NNP
en-wikipedia-org-4107	1277	29	(	(	-LRB-
en-wikipedia-org-4107	1277	30	March	March	NNP
en-wikipedia-org-4107	1277	31	2012	2012	CD
en-wikipedia-org-4107	1277	32	)	)	-RRB-
en-wikipedia-org-4107	1277	33	.	.	.
en-wikipedia-org-4107	1278	1	"	"	``
en-wikipedia-org-4107	1278	2	Sex	sex	NN
en-wikipedia-org-4107	1278	3	,	,	,
en-wikipedia-org-4107	1278	4	drugs	drug	NNS
en-wikipedia-org-4107	1278	5	,	,	,
en-wikipedia-org-4107	1278	6	and	and	CC
en-wikipedia-org-4107	1278	7	rock	rock	NN
en-wikipedia-org-4107	1278	8	'	'	CC
en-wikipedia-org-4107	1278	9	n	n	CC
en-wikipedia-org-4107	1278	10	'	'	CC
en-wikipedia-org-4107	1278	11	roll	roll	NN
en-wikipedia-org-4107	1278	12	:	:	:
en-wikipedia-org-4107	1278	13	hypothesizing	hypothesize	VBG
en-wikipedia-org-4107	1278	14	common	common	JJ
en-wikipedia-org-4107	1278	15	mesolimbic	mesolimbic	JJ
en-wikipedia-org-4107	1278	16	activation	activation	NN
en-wikipedia-org-4107	1278	17	as	as	IN
en-wikipedia-org-4107	1278	18	a	a	DT
en-wikipedia-org-4107	1278	19	function	function	NN
en-wikipedia-org-4107	1278	20	of	of	IN
en-wikipedia-org-4107	1278	21	reward	reward	NN
en-wikipedia-org-4107	1278	22	gene	gene	NN
en-wikipedia-org-4107	1278	23	polymorphisms	polymorphism	NNS
en-wikipedia-org-4107	1278	24	"	"	''
en-wikipedia-org-4107	1278	25	.	.	.
en-wikipedia-org-4107	1279	1	Journal	Journal	NNP
en-wikipedia-org-4107	1279	2	of	of	IN
en-wikipedia-org-4107	1279	3	Psychoactive	Psychoactive	NNP
en-wikipedia-org-4107	1279	4	Drugs	Drugs	NNPS
en-wikipedia-org-4107	1279	5	.	.	.
en-wikipedia-org-4107	1280	1	44	44	CD
en-wikipedia-org-4107	1280	2	(	(	-LRB-
en-wikipedia-org-4107	1280	3	1	1	CD
en-wikipedia-org-4107	1280	4	)	)	-RRB-
en-wikipedia-org-4107	1280	5	:	:	:
en-wikipedia-org-4107	1280	6	38–55	38–55	CD
en-wikipedia-org-4107	1280	7	.	.	.
en-wikipedia-org-4107	1281	1	doi:10.1080/02791072.2012.662112	doi:10.1080/02791072.2012.662112	NNP
en-wikipedia-org-4107	1281	2	.	.	.
en-wikipedia-org-4107	1282	1	PMC	PMC	NNP
en-wikipedia-org-4107	1282	2	 	  	_SP
en-wikipedia-org-4107	1282	3	4040958	4040958	CD
en-wikipedia-org-4107	1282	4	.	.	.
en-wikipedia-org-4107	1283	1	PMID	PMID	NNP
en-wikipedia-org-4107	1283	2	 	  	_SP
en-wikipedia-org-4107	1283	3	22641964	22641964	CD
en-wikipedia-org-4107	1283	4	.	.	.
en-wikipedia-org-4107	1284	1	It	-PRON-	PRP
en-wikipedia-org-4107	1284	2	has	have	VBZ
en-wikipedia-org-4107	1284	3	been	be	VBN
en-wikipedia-org-4107	1284	4	found	find	VBN
en-wikipedia-org-4107	1284	5	that	that	WDT
en-wikipedia-org-4107	1284	6	deltaFosB	deltaFosB	VBZ
en-wikipedia-org-4107	1284	7	gene	gene	NN
en-wikipedia-org-4107	1284	8	in	in	IN
en-wikipedia-org-4107	1284	9	the	the	DT
en-wikipedia-org-4107	1284	10	NAc	NAc	NNS
en-wikipedia-org-4107	1284	11	is	be	VBZ
en-wikipedia-org-4107	1284	12	critical	critical	JJ
en-wikipedia-org-4107	1284	13	for	for	IN
en-wikipedia-org-4107	1284	14	reinforcing	reinforce	VBG
en-wikipedia-org-4107	1284	15	effects	effect	NNS
en-wikipedia-org-4107	1284	16	of	of	IN
en-wikipedia-org-4107	1284	17	sexual	sexual	JJ
en-wikipedia-org-4107	1284	18	reward	reward	NN
en-wikipedia-org-4107	1284	19	.	.	.
en-wikipedia-org-4107	1285	1	Pitchers	pitcher	NNS
en-wikipedia-org-4107	1285	2	and	and	CC
en-wikipedia-org-4107	1285	3	colleagues	colleague	NNS
en-wikipedia-org-4107	1285	4	(	(	-LRB-
en-wikipedia-org-4107	1285	5	2010	2010	CD
en-wikipedia-org-4107	1285	6	)	)	-RRB-
en-wikipedia-org-4107	1285	7	reported	report	VBD
en-wikipedia-org-4107	1285	8	that	that	IN
en-wikipedia-org-4107	1285	9	sexual	sexual	JJ
en-wikipedia-org-4107	1285	10	experience	experience	NN
en-wikipedia-org-4107	1285	11	was	be	VBD
en-wikipedia-org-4107	1285	12	shown	show	VBN
en-wikipedia-org-4107	1285	13	to	to	TO
en-wikipedia-org-4107	1285	14	cause	cause	VB
en-wikipedia-org-4107	1285	15	DeltaFosB	DeltaFosB	VBD
en-wikipedia-org-4107	1285	16	accumulation	accumulation	NN
en-wikipedia-org-4107	1285	17	in	in	IN
en-wikipedia-org-4107	1285	18	several	several	JJ
en-wikipedia-org-4107	1285	19	limbic	limbic	JJ
en-wikipedia-org-4107	1285	20	brain	brain	NN
en-wikipedia-org-4107	1285	21	regions	region	NNS
en-wikipedia-org-4107	1285	22	including	include	VBG
en-wikipedia-org-4107	1285	23	the	the	DT
en-wikipedia-org-4107	1285	24	NAc	NAc	NNS
en-wikipedia-org-4107	1285	25	,	,	,
en-wikipedia-org-4107	1285	26	medial	medial	JJ
en-wikipedia-org-4107	1285	27	pre	pre	JJ
en-wikipedia-org-4107	1285	28	-	-	JJ
en-wikipedia-org-4107	1285	29	frontal	frontal	JJ
en-wikipedia-org-4107	1285	30	cortex	cortex	NN
en-wikipedia-org-4107	1285	31	,	,	,
en-wikipedia-org-4107	1285	32	VTA	VTA	NNP
en-wikipedia-org-4107	1285	33	,	,	,
en-wikipedia-org-4107	1285	34	caudate	caudate	NNP
en-wikipedia-org-4107	1285	35	,	,	,
en-wikipedia-org-4107	1285	36	and	and	CC
en-wikipedia-org-4107	1285	37	putamen	putamen	NN
en-wikipedia-org-4107	1285	38	,	,	,
en-wikipedia-org-4107	1285	39	but	but	CC
en-wikipedia-org-4107	1285	40	not	not	RB
en-wikipedia-org-4107	1285	41	the	the	DT
en-wikipedia-org-4107	1285	42	medial	medial	JJ
en-wikipedia-org-4107	1285	43	preoptic	preoptic	JJ
en-wikipedia-org-4107	1285	44	nucleus	nucleus	NN
en-wikipedia-org-4107	1285	45	.	.	.
en-wikipedia-org-4107	1286	1	...	...	NFP
en-wikipedia-org-4107	1286	2	these	these	DT
en-wikipedia-org-4107	1286	3	findings	finding	NNS
en-wikipedia-org-4107	1286	4	support	support	VBP
en-wikipedia-org-4107	1286	5	a	a	DT
en-wikipedia-org-4107	1286	6	critical	critical	JJ
en-wikipedia-org-4107	1286	7	role	role	NN
en-wikipedia-org-4107	1286	8	for	for	IN
en-wikipedia-org-4107	1286	9	DeltaFosB	DeltaFosB	NNP
en-wikipedia-org-4107	1286	10	expression	expression	NN
en-wikipedia-org-4107	1286	11	in	in	IN
en-wikipedia-org-4107	1286	12	the	the	DT
en-wikipedia-org-4107	1286	13	NAc	NAc	NNS
en-wikipedia-org-4107	1286	14	in	in	IN
en-wikipedia-org-4107	1286	15	the	the	DT
en-wikipedia-org-4107	1286	16	reinforcing	reinforce	VBG
en-wikipedia-org-4107	1286	17	effects	effect	NNS
en-wikipedia-org-4107	1286	18	of	of	IN
en-wikipedia-org-4107	1286	19	sexual	sexual	JJ
en-wikipedia-org-4107	1286	20	behavior	behavior	NN
en-wikipedia-org-4107	1286	21	and	and	CC
en-wikipedia-org-4107	1286	22	sexual	sexual	JJ
en-wikipedia-org-4107	1286	23	experience	experience	NN
en-wikipedia-org-4107	1286	24	-	-	HYPH
en-wikipedia-org-4107	1286	25	induced	induce	VBN
en-wikipedia-org-4107	1286	26	facilitation	facilitation	NN
en-wikipedia-org-4107	1286	27	of	of	IN
en-wikipedia-org-4107	1286	28	sexual	sexual	JJ
en-wikipedia-org-4107	1286	29	performance	performance	NN
en-wikipedia-org-4107	1286	30	.	.	.
en-wikipedia-org-4107	1287	1	...	...	NFP
en-wikipedia-org-4107	1287	2	both	both	DT
en-wikipedia-org-4107	1287	3	drug	drug	NN
en-wikipedia-org-4107	1287	4	addiction	addiction	NN
en-wikipedia-org-4107	1287	5	and	and	CC
en-wikipedia-org-4107	1287	6	sexual	sexual	JJ
en-wikipedia-org-4107	1287	7	addiction	addiction	NN
en-wikipedia-org-4107	1287	8	represent	represent	VBP
en-wikipedia-org-4107	1287	9	pathological	pathological	JJ
en-wikipedia-org-4107	1287	10	forms	form	NNS
en-wikipedia-org-4107	1287	11	of	of	IN
en-wikipedia-org-4107	1287	12	neuroplasticity	neuroplasticity	NN
en-wikipedia-org-4107	1287	13	along	along	IN
en-wikipedia-org-4107	1287	14	with	with	IN
en-wikipedia-org-4107	1287	15	the	the	DT
en-wikipedia-org-4107	1287	16	emergence	emergence	NN
en-wikipedia-org-4107	1287	17	of	of	IN
en-wikipedia-org-4107	1287	18	aberrant	aberrant	JJ
en-wikipedia-org-4107	1287	19	behaviors	behavior	NNS
en-wikipedia-org-4107	1287	20	involving	involve	VBG
en-wikipedia-org-4107	1287	21	a	a	DT
en-wikipedia-org-4107	1287	22	cascade	cascade	NN
en-wikipedia-org-4107	1287	23	of	of	IN
en-wikipedia-org-4107	1287	24	neurochemical	neurochemical	JJ
en-wikipedia-org-4107	1287	25	changes	change	NNS
en-wikipedia-org-4107	1287	26	mainly	mainly	RB
en-wikipedia-org-4107	1287	27	in	in	IN
en-wikipedia-org-4107	1287	28	the	the	DT
en-wikipedia-org-4107	1287	29	brain	brain	NN
en-wikipedia-org-4107	1287	30	's	's	POS
en-wikipedia-org-4107	1287	31	rewarding	rewarding	JJ
en-wikipedia-org-4107	1287	32	circuitry	circuitry	NN
en-wikipedia-org-4107	1287	33	.	.	.
en-wikipedia-org-4107	1288	1	^	^	NNP
en-wikipedia-org-4107	1288	2	Pitchers	Pitchers	NNP
en-wikipedia-org-4107	1288	3	KK	KK	NNP
en-wikipedia-org-4107	1288	4	,	,	,
en-wikipedia-org-4107	1288	5	Vialou	Vialou	NNP
en-wikipedia-org-4107	1288	6	V	V	NNP
en-wikipedia-org-4107	1288	7	,	,	,
en-wikipedia-org-4107	1288	8	Nestler	Nestler	NNP
en-wikipedia-org-4107	1288	9	EJ	EJ	NNP
en-wikipedia-org-4107	1288	10	,	,	,
en-wikipedia-org-4107	1288	11	Laviolette	Laviolette	NNP
en-wikipedia-org-4107	1288	12	SR	SR	NNP
en-wikipedia-org-4107	1288	13	,	,	,
en-wikipedia-org-4107	1288	14	Lehman	Lehman	NNP
en-wikipedia-org-4107	1288	15	MN	MN	NNP
en-wikipedia-org-4107	1288	16	,	,	,
en-wikipedia-org-4107	1288	17	Coolen	Coolen	NNP
en-wikipedia-org-4107	1288	18	LM	LM	NNP
en-wikipedia-org-4107	1288	19	(	(	-LRB-
en-wikipedia-org-4107	1288	20	February	February	NNP
en-wikipedia-org-4107	1288	21	2013	2013	CD
en-wikipedia-org-4107	1288	22	)	)	-RRB-
en-wikipedia-org-4107	1288	23	.	.	.
en-wikipedia-org-4107	1289	1	"	"	``
en-wikipedia-org-4107	1289	2	Natural	natural	JJ
en-wikipedia-org-4107	1289	3	and	and	CC
en-wikipedia-org-4107	1289	4	drug	drug	NN
en-wikipedia-org-4107	1289	5	rewards	reward	NNS
en-wikipedia-org-4107	1289	6	act	act	VBP
en-wikipedia-org-4107	1289	7	on	on	IN
en-wikipedia-org-4107	1289	8	common	common	JJ
en-wikipedia-org-4107	1289	9	neural	neural	JJ
en-wikipedia-org-4107	1289	10	plasticity	plasticity	NN
en-wikipedia-org-4107	1289	11	mechanisms	mechanism	NNS
en-wikipedia-org-4107	1289	12	with	with	IN
en-wikipedia-org-4107	1289	13	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	1289	14	as	as	IN
en-wikipedia-org-4107	1289	15	a	a	DT
en-wikipedia-org-4107	1289	16	key	key	JJ
en-wikipedia-org-4107	1289	17	mediator	mediator	NN
en-wikipedia-org-4107	1289	18	"	"	''
en-wikipedia-org-4107	1289	19	.	.	.
en-wikipedia-org-4107	1290	1	The	the	DT
en-wikipedia-org-4107	1290	2	Journal	Journal	NNP
en-wikipedia-org-4107	1290	3	of	of	IN
en-wikipedia-org-4107	1290	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1290	5	.	.	.
en-wikipedia-org-4107	1291	1	33	33	CD
en-wikipedia-org-4107	1291	2	(	(	-LRB-
en-wikipedia-org-4107	1291	3	8)	8)	CD
en-wikipedia-org-4107	1291	4	:	:	SYM
en-wikipedia-org-4107	1291	5	3434–3442	3434–3442	CD
en-wikipedia-org-4107	1291	6	.	.	.
en-wikipedia-org-4107	1292	1	doi:10.1523	doi:10.1523	NNP
en-wikipedia-org-4107	1292	2	/	/	SYM
en-wikipedia-org-4107	1292	3	JNEUROSCI.4881	JNEUROSCI.4881	NNP
en-wikipedia-org-4107	1292	4	-	-	:
en-wikipedia-org-4107	1292	5	12.2013	12.2013	CD
en-wikipedia-org-4107	1292	6	.	.	.
en-wikipedia-org-4107	1293	1	PMC	PMC	NNP
en-wikipedia-org-4107	1293	2	 	  	_SP
en-wikipedia-org-4107	1293	3	3865508	3865508	CD
en-wikipedia-org-4107	1293	4	.	.	.
en-wikipedia-org-4107	1294	1	PMID	PMID	NNP
en-wikipedia-org-4107	1294	2	 	  	_SP
en-wikipedia-org-4107	1294	3	23426671	23426671	CD
en-wikipedia-org-4107	1294	4	.	.	.
en-wikipedia-org-4107	1295	1	^	^	NNP
en-wikipedia-org-4107	1295	2	Beloate	Beloate	NNP
en-wikipedia-org-4107	1295	3	LN	LN	NNP
en-wikipedia-org-4107	1295	4	,	,	,
en-wikipedia-org-4107	1295	5	Weems	Weems	NNP
en-wikipedia-org-4107	1295	6	PW	PW	NNP
en-wikipedia-org-4107	1295	7	,	,	,
en-wikipedia-org-4107	1295	8	Casey	Casey	NNP
en-wikipedia-org-4107	1295	9	GR	GR	NNP
en-wikipedia-org-4107	1295	10	,	,	,
en-wikipedia-org-4107	1295	11	Webb	Webb	NNP
en-wikipedia-org-4107	1295	12	IC	IC	NNP
en-wikipedia-org-4107	1295	13	,	,	,
en-wikipedia-org-4107	1295	14	Coolen	Coolen	NNP
en-wikipedia-org-4107	1295	15	LM	LM	NNP
en-wikipedia-org-4107	1295	16	(	(	-LRB-
en-wikipedia-org-4107	1295	17	February	February	NNP
en-wikipedia-org-4107	1295	18	2016	2016	CD
en-wikipedia-org-4107	1295	19	)	)	-RRB-
en-wikipedia-org-4107	1295	20	.	.	.
en-wikipedia-org-4107	1296	1	"	"	``
en-wikipedia-org-4107	1296	2	Nucleus	Nucleus	NNP
en-wikipedia-org-4107	1296	3	accumbens	accumben	VBZ
en-wikipedia-org-4107	1296	4	NMDA	NMDA	NNP
en-wikipedia-org-4107	1296	5	receptor	receptor	NN
en-wikipedia-org-4107	1296	6	activation	activation	NN
en-wikipedia-org-4107	1296	7	regulates	regulate	NNS
en-wikipedia-org-4107	1296	8	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1296	9	cross	cross	JJ
en-wikipedia-org-4107	1296	10	-	-	JJ
en-wikipedia-org-4107	1296	11	sensitization	sensitization	JJ
en-wikipedia-org-4107	1296	12	and	and	CC
en-wikipedia-org-4107	1296	13	deltaFosB	deltaFosB	VBZ
en-wikipedia-org-4107	1296	14	expression	expression	NN
en-wikipedia-org-4107	1296	15	following	follow	VBG
en-wikipedia-org-4107	1296	16	sexual	sexual	JJ
en-wikipedia-org-4107	1296	17	experience	experience	NN
en-wikipedia-org-4107	1296	18	in	in	IN
en-wikipedia-org-4107	1296	19	male	male	JJ
en-wikipedia-org-4107	1296	20	rats	rat	NNS
en-wikipedia-org-4107	1296	21	"	"	''
en-wikipedia-org-4107	1296	22	.	.	.
en-wikipedia-org-4107	1297	1	Neuropharmacology	neuropharmacology	NN
en-wikipedia-org-4107	1297	2	.	.	.
en-wikipedia-org-4107	1298	1	101	101	CD
en-wikipedia-org-4107	1298	2	:	:	SYM
en-wikipedia-org-4107	1298	3	154–164	154–164	CD
en-wikipedia-org-4107	1298	4	.	.	.
en-wikipedia-org-4107	1299	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1299	2	/	/	SYM
en-wikipedia-org-4107	1299	3	j.neuropharm.2015.09.023	j.neuropharm.2015.09.023	JJ
en-wikipedia-org-4107	1299	4	.	.	.
en-wikipedia-org-4107	1300	1	PMID	PMID	NNP
en-wikipedia-org-4107	1300	2	 	  	_SP
en-wikipedia-org-4107	1300	3	26391065	26391065	CD
en-wikipedia-org-4107	1300	4	.	.	.
en-wikipedia-org-4107	1301	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1301	2	 	  	_SP
en-wikipedia-org-4107	1301	3	25317397	25317397	CD
en-wikipedia-org-4107	1301	4	.	.	.
en-wikipedia-org-4107	1302	1	^	^	NNP
en-wikipedia-org-4107	1302	2	Malenka	Malenka	NNP
en-wikipedia-org-4107	1302	3	RC	RC	NNP
en-wikipedia-org-4107	1302	4	,	,	,
en-wikipedia-org-4107	1302	5	Nestler	Nestler	NNP
en-wikipedia-org-4107	1302	6	EJ	EJ	NNP
en-wikipedia-org-4107	1302	7	,	,	,
en-wikipedia-org-4107	1302	8	Hyman	Hyman	NNP
en-wikipedia-org-4107	1302	9	SE	SE	NNP
en-wikipedia-org-4107	1302	10	,	,	,
en-wikipedia-org-4107	1302	11	Holtzman	Holtzman	NNP
en-wikipedia-org-4107	1302	12	DM	DM	NNP
en-wikipedia-org-4107	1302	13	(	(	-LRB-
en-wikipedia-org-4107	1302	14	2015	2015	CD
en-wikipedia-org-4107	1302	15	)	)	-RRB-
en-wikipedia-org-4107	1302	16	.	.	.
en-wikipedia-org-4107	1303	1	"	"	``
en-wikipedia-org-4107	1303	2	Chapter	chapter	NN
en-wikipedia-org-4107	1303	3	16	16	CD
en-wikipedia-org-4107	1303	4	:	:	:
en-wikipedia-org-4107	1303	5	Reinforcement	reinforcement	NN
en-wikipedia-org-4107	1303	6	and	and	CC
en-wikipedia-org-4107	1303	7	Addictive	Addictive	NNP
en-wikipedia-org-4107	1303	8	Disorders	Disorders	NNPS
en-wikipedia-org-4107	1303	9	"	"	''
en-wikipedia-org-4107	1303	10	.	.	.
en-wikipedia-org-4107	1304	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	1304	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-4107	1304	3	:	:	:
en-wikipedia-org-4107	1304	4	A	A	NNP
en-wikipedia-org-4107	1304	5	Foundation	Foundation	NNP
en-wikipedia-org-4107	1304	6	for	for	IN
en-wikipedia-org-4107	1304	7	Clinical	Clinical	NNP
en-wikipedia-org-4107	1304	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1304	9	(	(	-LRB-
en-wikipedia-org-4107	1304	10	3rd	3rd	NNP
en-wikipedia-org-4107	1304	11	ed	ed	NNP
en-wikipedia-org-4107	1304	12	.	.	.
en-wikipedia-org-4107	1304	13	)	)	-RRB-
en-wikipedia-org-4107	1304	14	.	.	.
en-wikipedia-org-4107	1305	1	New	New	NNP
en-wikipedia-org-4107	1305	2	York	York	NNP
en-wikipedia-org-4107	1305	3	:	:	:
en-wikipedia-org-4107	1305	4	McGraw	McGraw	NNP
en-wikipedia-org-4107	1305	5	-	-	HYPH
en-wikipedia-org-4107	1305	6	Hill	Hill	NNP
en-wikipedia-org-4107	1305	7	Medical	Medical	NNP
en-wikipedia-org-4107	1305	8	.	.	.
en-wikipedia-org-4107	1306	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	1306	2	 	  	_SP
en-wikipedia-org-4107	1306	3	9780071827706	9780071827706	CD
en-wikipedia-org-4107	1306	4	.	.	.
en-wikipedia-org-4107	1307	1	Pharmacologic	pharmacologic	JJ
en-wikipedia-org-4107	1307	2	treatment	treatment	NN
en-wikipedia-org-4107	1307	3	for	for	IN
en-wikipedia-org-4107	1307	4	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	1307	5	addiction	addiction	NN
en-wikipedia-org-4107	1307	6	is	be	VBZ
en-wikipedia-org-4107	1307	7	generally	generally	RB
en-wikipedia-org-4107	1307	8	unsatisfactory	unsatisfactory	JJ
en-wikipedia-org-4107	1307	9	.	.	.
en-wikipedia-org-4107	1308	1	As	as	IN
en-wikipedia-org-4107	1308	2	previously	previously	RB
en-wikipedia-org-4107	1308	3	discussed	discuss	VBN
en-wikipedia-org-4107	1308	4	,	,	,
en-wikipedia-org-4107	1308	5	cessation	cessation	NN
en-wikipedia-org-4107	1308	6	of	of	IN
en-wikipedia-org-4107	1308	7	cocaine	cocaine	NN
en-wikipedia-org-4107	1308	8	use	use	NN
en-wikipedia-org-4107	1308	9	and	and	CC
en-wikipedia-org-4107	1308	10	the	the	DT
en-wikipedia-org-4107	1308	11	use	use	NN
en-wikipedia-org-4107	1308	12	of	of	IN
en-wikipedia-org-4107	1308	13	other	other	JJ
en-wikipedia-org-4107	1308	14	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	1308	15	in	in	IN
en-wikipedia-org-4107	1308	16	dependent	dependent	JJ
en-wikipedia-org-4107	1308	17	individuals	individual	NNS
en-wikipedia-org-4107	1308	18	does	do	VBZ
en-wikipedia-org-4107	1308	19	not	not	RB
en-wikipedia-org-4107	1308	20	produce	produce	VB
en-wikipedia-org-4107	1308	21	a	a	DT
en-wikipedia-org-4107	1308	22	physical	physical	JJ
en-wikipedia-org-4107	1308	23	withdrawal	withdrawal	NN
en-wikipedia-org-4107	1308	24	syndrome	syndrome	NN
en-wikipedia-org-4107	1308	25	but	but	CC
en-wikipedia-org-4107	1308	26	may	may	MD
en-wikipedia-org-4107	1308	27	produce	produce	VB
en-wikipedia-org-4107	1308	28	dysphoria	dysphoria	NNP
en-wikipedia-org-4107	1308	29	,	,	,
en-wikipedia-org-4107	1308	30	anhedonia	anhedonia	NNP
en-wikipedia-org-4107	1308	31	,	,	,
en-wikipedia-org-4107	1308	32	and	and	CC
en-wikipedia-org-4107	1308	33	an	an	DT
en-wikipedia-org-4107	1308	34	intense	intense	JJ
en-wikipedia-org-4107	1308	35	desire	desire	NN
en-wikipedia-org-4107	1308	36	to	to	TO
en-wikipedia-org-4107	1308	37	reinitiate	reinitiate	VB
en-wikipedia-org-4107	1308	38	drug	drug	NN
en-wikipedia-org-4107	1308	39	use	use	NN
en-wikipedia-org-4107	1308	40	.	.	.
en-wikipedia-org-4107	1309	1	^	^	NNP
en-wikipedia-org-4107	1309	2	a	a	DT
en-wikipedia-org-4107	1309	3	b	b	NN
en-wikipedia-org-4107	1309	4	c	c	NN
en-wikipedia-org-4107	1309	5	d	d	NN
en-wikipedia-org-4107	1309	6	Chan	Chan	NNP
en-wikipedia-org-4107	1309	7	B	B	NNP
en-wikipedia-org-4107	1309	8	,	,	,
en-wikipedia-org-4107	1309	9	Freeman	Freeman	NNP
en-wikipedia-org-4107	1309	10	M	M	NNP
en-wikipedia-org-4107	1309	11	,	,	,
en-wikipedia-org-4107	1309	12	Kondo	Kondo	NNP
en-wikipedia-org-4107	1309	13	K	K	NNP
en-wikipedia-org-4107	1309	14	,	,	,
en-wikipedia-org-4107	1309	15	Ayers	Ayers	NNP
en-wikipedia-org-4107	1309	16	C	C	NNP
en-wikipedia-org-4107	1309	17	,	,	,
en-wikipedia-org-4107	1309	18	Montgomery	Montgomery	NNP
en-wikipedia-org-4107	1309	19	J	J	NNP
en-wikipedia-org-4107	1309	20	,	,	,
en-wikipedia-org-4107	1309	21	Paynter	Paynter	NNP
en-wikipedia-org-4107	1309	22	R	R	NNP
en-wikipedia-org-4107	1309	23	,	,	,
en-wikipedia-org-4107	1309	24	Kansagara	Kansagara	NNP
en-wikipedia-org-4107	1309	25	D	D	NNP
en-wikipedia-org-4107	1309	26	(	(	-LRB-
en-wikipedia-org-4107	1309	27	December	December	NNP
en-wikipedia-org-4107	1309	28	2019	2019	CD
en-wikipedia-org-4107	1309	29	)	)	-RRB-
en-wikipedia-org-4107	1309	30	.	.	.
en-wikipedia-org-4107	1310	1	"	"	``
en-wikipedia-org-4107	1310	2	Pharmacotherapy	Pharmacotherapy	NNP
en-wikipedia-org-4107	1310	3	for	for	IN
en-wikipedia-org-4107	1310	4	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	1310	5	/	/	SYM
en-wikipedia-org-4107	1310	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1310	7	use	use	NN
en-wikipedia-org-4107	1310	8	disorder	disorder	NN
en-wikipedia-org-4107	1310	9	-	-	:
en-wikipedia-org-4107	1310	10	a	a	DT
en-wikipedia-org-4107	1310	11	systematic	systematic	JJ
en-wikipedia-org-4107	1310	12	review	review	NN
en-wikipedia-org-4107	1310	13	and	and	CC
en-wikipedia-org-4107	1310	14	meta	meta	JJ
en-wikipedia-org-4107	1310	15	-	-	HYPH
en-wikipedia-org-4107	1310	16	analysis	analysis	NN
en-wikipedia-org-4107	1310	17	"	"	''
en-wikipedia-org-4107	1310	18	.	.	.
en-wikipedia-org-4107	1311	1	Addiction	addiction	NN
en-wikipedia-org-4107	1311	2	(	(	-LRB-
en-wikipedia-org-4107	1311	3	Abingdon	Abingdon	NNP
en-wikipedia-org-4107	1311	4	,	,	,
en-wikipedia-org-4107	1311	5	England	England	NNP
en-wikipedia-org-4107	1311	6	)	)	-RRB-
en-wikipedia-org-4107	1311	7	.	.	.
en-wikipedia-org-4107	1312	1	114	114	CD
en-wikipedia-org-4107	1312	2	(	(	-LRB-
en-wikipedia-org-4107	1312	3	12	12	CD
en-wikipedia-org-4107	1312	4	)	)	-RRB-
en-wikipedia-org-4107	1312	5	:	:	:
en-wikipedia-org-4107	1312	6	2122–2136	2122–2136	CD
en-wikipedia-org-4107	1312	7	.	.	.
en-wikipedia-org-4107	1313	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-4107	1313	2	/	/	SYM
en-wikipedia-org-4107	1313	3	add.14755	add.14755	NNP
en-wikipedia-org-4107	1313	4	.	.	.
en-wikipedia-org-4107	1314	1	PMID	PMID	NNP
en-wikipedia-org-4107	1314	2	 	  	_SP
en-wikipedia-org-4107	1314	3	31328345	31328345	CD
en-wikipedia-org-4107	1314	4	.	.	.
en-wikipedia-org-4107	1315	1	^	^	NN
en-wikipedia-org-4107	1315	2	Stoops	Stoops	NNP
en-wikipedia-org-4107	1315	3	WW	WW	NNP
en-wikipedia-org-4107	1315	4	,	,	,
en-wikipedia-org-4107	1315	5	Rush	Rush	NNP
en-wikipedia-org-4107	1315	6	CR	CR	NNP
en-wikipedia-org-4107	1315	7	(	(	-LRB-
en-wikipedia-org-4107	1315	8	May	May	NNP
en-wikipedia-org-4107	1315	9	2014	2014	CD
en-wikipedia-org-4107	1315	10	)	)	-RRB-
en-wikipedia-org-4107	1315	11	.	.	.
en-wikipedia-org-4107	1316	1	"	"	``
en-wikipedia-org-4107	1316	2	Combination	combination	NN
en-wikipedia-org-4107	1316	3	pharmacotherapies	pharmacotherapie	NNS
en-wikipedia-org-4107	1316	4	for	for	IN
en-wikipedia-org-4107	1316	5	stimulant	stimulant	NN
en-wikipedia-org-4107	1316	6	use	use	NN
en-wikipedia-org-4107	1316	7	disorder	disorder	NN
en-wikipedia-org-4107	1316	8	:	:	:
en-wikipedia-org-4107	1316	9	a	a	DT
en-wikipedia-org-4107	1316	10	review	review	NN
en-wikipedia-org-4107	1316	11	of	of	IN
en-wikipedia-org-4107	1316	12	clinical	clinical	JJ
en-wikipedia-org-4107	1316	13	findings	finding	NNS
en-wikipedia-org-4107	1316	14	and	and	CC
en-wikipedia-org-4107	1316	15	recommendations	recommendation	NNS
en-wikipedia-org-4107	1316	16	for	for	IN
en-wikipedia-org-4107	1316	17	future	future	JJ
en-wikipedia-org-4107	1316	18	research	research	NN
en-wikipedia-org-4107	1316	19	"	"	''
en-wikipedia-org-4107	1316	20	.	.	.
en-wikipedia-org-4107	1317	1	Expert	Expert	NNP
en-wikipedia-org-4107	1317	2	Review	Review	NNP
en-wikipedia-org-4107	1317	3	of	of	IN
en-wikipedia-org-4107	1317	4	Clinical	Clinical	NNP
en-wikipedia-org-4107	1317	5	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1317	6	.	.	.
en-wikipedia-org-4107	1318	1	7	7	CD
en-wikipedia-org-4107	1318	2	(	(	-LRB-
en-wikipedia-org-4107	1318	3	3	3	CD
en-wikipedia-org-4107	1318	4	)	)	-RRB-
en-wikipedia-org-4107	1318	5	:	:	:
en-wikipedia-org-4107	1318	6	363–374	363–374	CD
en-wikipedia-org-4107	1318	7	.	.	.
en-wikipedia-org-4107	1319	1	doi:10.1586/17512433.2014.909283	doi:10.1586/17512433.2014.909283	NNP
en-wikipedia-org-4107	1319	2	.	.	.
en-wikipedia-org-4107	1320	1	PMC	PMC	NNP
en-wikipedia-org-4107	1320	2	 	  	_SP
en-wikipedia-org-4107	1320	3	4017926	4017926	CD
en-wikipedia-org-4107	1320	4	.	.	.
en-wikipedia-org-4107	1321	1	PMID	PMID	NNP
en-wikipedia-org-4107	1321	2	 	  	_SP
en-wikipedia-org-4107	1321	3	24716825	24716825	CD
en-wikipedia-org-4107	1321	4	.	.	.
en-wikipedia-org-4107	1322	1	Despite	despite	IN
en-wikipedia-org-4107	1322	2	concerted	concerted	JJ
en-wikipedia-org-4107	1322	3	efforts	effort	NNS
en-wikipedia-org-4107	1322	4	to	to	TO
en-wikipedia-org-4107	1322	5	identify	identify	VB
en-wikipedia-org-4107	1322	6	a	a	DT
en-wikipedia-org-4107	1322	7	pharmacotherapy	pharmacotherapy	NN
en-wikipedia-org-4107	1322	8	for	for	IN
en-wikipedia-org-4107	1322	9	managing	manage	VBG
en-wikipedia-org-4107	1322	10	stimulant	stimulant	JJ
en-wikipedia-org-4107	1322	11	use	use	NN
en-wikipedia-org-4107	1322	12	disorders	disorder	NNS
en-wikipedia-org-4107	1322	13	,	,	,
en-wikipedia-org-4107	1322	14	no	no	DT
en-wikipedia-org-4107	1322	15	widely	widely	RB
en-wikipedia-org-4107	1322	16	effective	effective	JJ
en-wikipedia-org-4107	1322	17	medications	medication	NNS
en-wikipedia-org-4107	1322	18	have	have	VBP
en-wikipedia-org-4107	1322	19	been	be	VBN
en-wikipedia-org-4107	1322	20	approved	approve	VBN
en-wikipedia-org-4107	1322	21	.	.	.
en-wikipedia-org-4107	1323	1	^	^	NNP
en-wikipedia-org-4107	1323	2	a	a	DT
en-wikipedia-org-4107	1323	3	b	b	NNP
en-wikipedia-org-4107	1323	4	Jing	Jing	NNP
en-wikipedia-org-4107	1323	5	L	L	NNP
en-wikipedia-org-4107	1323	6	,	,	,
en-wikipedia-org-4107	1323	7	Li	Li	NNP
en-wikipedia-org-4107	1323	8	JX	JX	NNP
en-wikipedia-org-4107	1323	9	(	(	-LRB-
en-wikipedia-org-4107	1323	10	August	August	NNP
en-wikipedia-org-4107	1323	11	2015	2015	CD
en-wikipedia-org-4107	1323	12	)	)	-RRB-
en-wikipedia-org-4107	1323	13	.	.	.
en-wikipedia-org-4107	1324	1	"	"	``
en-wikipedia-org-4107	1324	2	Trace	trace	NN
en-wikipedia-org-4107	1324	3	amine	amine	NN
en-wikipedia-org-4107	1324	4	-	-	HYPH
en-wikipedia-org-4107	1324	5	associated	associate	VBN
en-wikipedia-org-4107	1324	6	receptor	receptor	NN
en-wikipedia-org-4107	1324	7	1	1	CD
en-wikipedia-org-4107	1324	8	:	:	:
en-wikipedia-org-4107	1324	9	A	a	DT
en-wikipedia-org-4107	1324	10	promising	promising	JJ
en-wikipedia-org-4107	1324	11	target	target	NN
en-wikipedia-org-4107	1324	12	for	for	IN
en-wikipedia-org-4107	1324	13	the	the	DT
en-wikipedia-org-4107	1324	14	treatment	treatment	NN
en-wikipedia-org-4107	1324	15	of	of	IN
en-wikipedia-org-4107	1324	16	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	1324	17	addiction	addiction	NN
en-wikipedia-org-4107	1324	18	"	"	''
en-wikipedia-org-4107	1324	19	.	.	.
en-wikipedia-org-4107	1325	1	European	European	NNP
en-wikipedia-org-4107	1325	2	Journal	Journal	NNP
en-wikipedia-org-4107	1325	3	of	of	IN
en-wikipedia-org-4107	1325	4	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1325	5	.	.	.
en-wikipedia-org-4107	1326	1	761	761	CD
en-wikipedia-org-4107	1326	2	:	:	:
en-wikipedia-org-4107	1326	3	345–352	345–352	CD
en-wikipedia-org-4107	1326	4	.	.	.
en-wikipedia-org-4107	1327	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1327	2	/	/	SYM
en-wikipedia-org-4107	1327	3	j.ejphar.2015.06.019	j.ejphar.2015.06.019	$
en-wikipedia-org-4107	1327	4	.	.	.
en-wikipedia-org-4107	1328	1	PMC	PMC	NNP
en-wikipedia-org-4107	1328	2	 	  	_SP
en-wikipedia-org-4107	1328	3	4532615	4532615	CD
en-wikipedia-org-4107	1328	4	.	.	.
en-wikipedia-org-4107	1329	1	PMID	PMID	NNP
en-wikipedia-org-4107	1329	2	 	  	_SP
en-wikipedia-org-4107	1329	3	26092759	26092759	CD
en-wikipedia-org-4107	1329	4	.	.	.
en-wikipedia-org-4107	1330	1	Existing	exist	VBG
en-wikipedia-org-4107	1330	2	data	datum	NNS
en-wikipedia-org-4107	1330	3	provided	provide	VBD
en-wikipedia-org-4107	1330	4	robust	robust	JJ
en-wikipedia-org-4107	1330	5	preclinical	preclinical	JJ
en-wikipedia-org-4107	1330	6	evidence	evidence	NN
en-wikipedia-org-4107	1330	7	supporting	support	VBG
en-wikipedia-org-4107	1330	8	the	the	DT
en-wikipedia-org-4107	1330	9	development	development	NN
en-wikipedia-org-4107	1330	10	of	of	IN
en-wikipedia-org-4107	1330	11	TAAR1	taar1	NN
en-wikipedia-org-4107	1330	12	agonists	agonist	NNS
en-wikipedia-org-4107	1330	13	as	as	IN
en-wikipedia-org-4107	1330	14	potential	potential	JJ
en-wikipedia-org-4107	1330	15	treatment	treatment	NN
en-wikipedia-org-4107	1330	16	for	for	IN
en-wikipedia-org-4107	1330	17	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	1330	18	abuse	abuse	NN
en-wikipedia-org-4107	1330	19	and	and	CC
en-wikipedia-org-4107	1330	20	addiction	addiction	NN
en-wikipedia-org-4107	1330	21	.	.	.
en-wikipedia-org-4107	1331	1	^	^	NNP
en-wikipedia-org-4107	1331	2	a	a	DT
en-wikipedia-org-4107	1331	3	b	b	NNP
en-wikipedia-org-4107	1331	4	Malenka	Malenka	NNP
en-wikipedia-org-4107	1331	5	RC	RC	NNP
en-wikipedia-org-4107	1331	6	,	,	,
en-wikipedia-org-4107	1331	7	Nestler	Nestler	NNP
en-wikipedia-org-4107	1331	8	EJ	EJ	NNP
en-wikipedia-org-4107	1331	9	,	,	,
en-wikipedia-org-4107	1331	10	Hyman	Hyman	NNP
en-wikipedia-org-4107	1331	11	SE	SE	NNP
en-wikipedia-org-4107	1331	12	(	(	-LRB-
en-wikipedia-org-4107	1331	13	2009	2009	CD
en-wikipedia-org-4107	1331	14	)	)	-RRB-
en-wikipedia-org-4107	1331	15	.	.	.
en-wikipedia-org-4107	1332	1	"	"	``
en-wikipedia-org-4107	1332	2	Chapter	chapter	NN
en-wikipedia-org-4107	1332	3	5	5	CD
en-wikipedia-org-4107	1332	4	:	:	:
en-wikipedia-org-4107	1332	5	Excitatory	excitatory	NN
en-wikipedia-org-4107	1332	6	and	and	CC
en-wikipedia-org-4107	1332	7	Inhibitory	Inhibitory	NNP
en-wikipedia-org-4107	1332	8	Amino	Amino	NNP
en-wikipedia-org-4107	1332	9	Acids	Acids	NNPS
en-wikipedia-org-4107	1332	10	"	"	''
en-wikipedia-org-4107	1332	11	.	.	.
en-wikipedia-org-4107	1333	1	In	in	IN
en-wikipedia-org-4107	1333	2	Sydor	Sydor	NNP
en-wikipedia-org-4107	1333	3	A	A	NNP
en-wikipedia-org-4107	1333	4	,	,	,
en-wikipedia-org-4107	1333	5	Brown	Brown	NNP
en-wikipedia-org-4107	1333	6	RY	RY	NNP
en-wikipedia-org-4107	1333	7	(	(	-LRB-
en-wikipedia-org-4107	1333	8	eds	eds	NNP
en-wikipedia-org-4107	1333	9	.	.	.
en-wikipedia-org-4107	1333	10	)	)	-RRB-
en-wikipedia-org-4107	1333	11	.	.	.
en-wikipedia-org-4107	1334	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	1334	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-4107	1334	3	:	:	:
en-wikipedia-org-4107	1334	4	A	A	NNP
en-wikipedia-org-4107	1334	5	Foundation	Foundation	NNP
en-wikipedia-org-4107	1334	6	for	for	IN
en-wikipedia-org-4107	1334	7	Clinical	Clinical	NNP
en-wikipedia-org-4107	1334	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1334	9	(	(	-LRB-
en-wikipedia-org-4107	1334	10	2nd	2nd	NNP
en-wikipedia-org-4107	1334	11	ed	ed	NNP
en-wikipedia-org-4107	1334	12	.	.	.
en-wikipedia-org-4107	1334	13	)	)	-RRB-
en-wikipedia-org-4107	1334	14	.	.	.
en-wikipedia-org-4107	1335	1	New	New	NNP
en-wikipedia-org-4107	1335	2	York	York	NNP
en-wikipedia-org-4107	1335	3	,	,	,
en-wikipedia-org-4107	1335	4	USA	USA	NNP
en-wikipedia-org-4107	1335	5	:	:	:
en-wikipedia-org-4107	1335	6	McGraw	McGraw	NNP
en-wikipedia-org-4107	1335	7	-	-	HYPH
en-wikipedia-org-4107	1335	8	Hill	Hill	NNP
en-wikipedia-org-4107	1335	9	Medical	Medical	NNP
en-wikipedia-org-4107	1335	10	.	.	.
en-wikipedia-org-4107	1336	1	pp	pp	NNP
en-wikipedia-org-4107	1336	2	.	.	.
en-wikipedia-org-4107	1337	1	124–125	124–125	CD
en-wikipedia-org-4107	1337	2	.	.	.
en-wikipedia-org-4107	1338	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	1338	2	 	  	_SP
en-wikipedia-org-4107	1338	3	9780071481274	9780071481274	CD
en-wikipedia-org-4107	1338	4	.	.	.
en-wikipedia-org-4107	1339	1	^	^	NNP
en-wikipedia-org-4107	1339	2	a	a	DT
en-wikipedia-org-4107	1339	3	b	b	NNP
en-wikipedia-org-4107	1339	4	De	De	NNP
en-wikipedia-org-4107	1339	5	Crescenzo	Crescenzo	NNP
en-wikipedia-org-4107	1339	6	F	F	NNP
en-wikipedia-org-4107	1339	7	,	,	,
en-wikipedia-org-4107	1339	8	Ciabattini	Ciabattini	NNP
en-wikipedia-org-4107	1339	9	M	M	NNP
en-wikipedia-org-4107	1339	10	,	,	,
en-wikipedia-org-4107	1339	11	D'Alò	D'Alò	NNP
en-wikipedia-org-4107	1339	12	GL	GL	NNP
en-wikipedia-org-4107	1339	13	,	,	,
en-wikipedia-org-4107	1339	14	De	De	NNP
en-wikipedia-org-4107	1339	15	Giorgi	Giorgi	NNP
en-wikipedia-org-4107	1339	16	R	R	NNP
en-wikipedia-org-4107	1339	17	,	,	,
en-wikipedia-org-4107	1339	18	Del	Del	NNP
en-wikipedia-org-4107	1339	19	Giovane	Giovane	NNP
en-wikipedia-org-4107	1339	20	C	C	NNP
en-wikipedia-org-4107	1339	21	,	,	,
en-wikipedia-org-4107	1339	22	Cassar	Cassar	NNP
en-wikipedia-org-4107	1339	23	C	C	NNP
en-wikipedia-org-4107	1339	24	,	,	,
en-wikipedia-org-4107	1339	25	Janiri	Janiri	NNP
en-wikipedia-org-4107	1339	26	L	L	NNP
en-wikipedia-org-4107	1339	27	,	,	,
en-wikipedia-org-4107	1339	28	Clark	Clark	NNP
en-wikipedia-org-4107	1339	29	N	N	NNP
en-wikipedia-org-4107	1339	30	,	,	,
en-wikipedia-org-4107	1339	31	Ostacher	Ostacher	NNP
en-wikipedia-org-4107	1339	32	MJ	MJ	NNP
en-wikipedia-org-4107	1339	33	,	,	,
en-wikipedia-org-4107	1339	34	Cipriani	Cipriani	NNP
en-wikipedia-org-4107	1339	35	A	a	NN
en-wikipedia-org-4107	1339	36	(	(	-LRB-
en-wikipedia-org-4107	1339	37	December	December	NNP
en-wikipedia-org-4107	1339	38	2018	2018	CD
en-wikipedia-org-4107	1339	39	)	)	-RRB-
en-wikipedia-org-4107	1339	40	.	.	.
en-wikipedia-org-4107	1340	1	"	"	``
en-wikipedia-org-4107	1340	2	Comparative	comparative	JJ
en-wikipedia-org-4107	1340	3	efficacy	efficacy	NN
en-wikipedia-org-4107	1340	4	and	and	CC
en-wikipedia-org-4107	1340	5	acceptability	acceptability	NN
en-wikipedia-org-4107	1340	6	of	of	IN
en-wikipedia-org-4107	1340	7	psychosocial	psychosocial	JJ
en-wikipedia-org-4107	1340	8	interventions	intervention	NNS
en-wikipedia-org-4107	1340	9	for	for	IN
en-wikipedia-org-4107	1340	10	individuals	individual	NNS
en-wikipedia-org-4107	1340	11	with	with	IN
en-wikipedia-org-4107	1340	12	cocaine	cocaine	NN
en-wikipedia-org-4107	1340	13	and	and	CC
en-wikipedia-org-4107	1340	14	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1340	15	addiction	addiction	NN
en-wikipedia-org-4107	1340	16	:	:	:
en-wikipedia-org-4107	1340	17	A	a	DT
en-wikipedia-org-4107	1340	18	systematic	systematic	JJ
en-wikipedia-org-4107	1340	19	review	review	NN
en-wikipedia-org-4107	1340	20	and	and	CC
en-wikipedia-org-4107	1340	21	network	network	NN
en-wikipedia-org-4107	1340	22	meta	meta	JJ
en-wikipedia-org-4107	1340	23	-	-	HYPH
en-wikipedia-org-4107	1340	24	analysis	analysis	NN
en-wikipedia-org-4107	1340	25	"	"	''
en-wikipedia-org-4107	1340	26	.	.	.
en-wikipedia-org-4107	1341	1	PLOS	PLOS	NNP
en-wikipedia-org-4107	1341	2	Medicine	Medicine	NNP
en-wikipedia-org-4107	1341	3	.	.	.
en-wikipedia-org-4107	1342	1	15	15	CD
en-wikipedia-org-4107	1342	2	(	(	-LRB-
en-wikipedia-org-4107	1342	3	12	12	CD
en-wikipedia-org-4107	1342	4	)	)	-RRB-
en-wikipedia-org-4107	1342	5	:	:	:
en-wikipedia-org-4107	1342	6	e1002715	e1002715	JJ
en-wikipedia-org-4107	1342	7	.	.	.
en-wikipedia-org-4107	1343	1	doi:10.1371	doi:10.1371	LS
en-wikipedia-org-4107	1343	2	/	/	SYM
en-wikipedia-org-4107	1343	3	journal.pmed.1002715	journal.pmed.1002715	NNS
en-wikipedia-org-4107	1343	4	.	.	.
en-wikipedia-org-4107	1344	1	PMC	PMC	NNP
en-wikipedia-org-4107	1344	2	 	  	_SP
en-wikipedia-org-4107	1344	3	6306153	6306153	CD
en-wikipedia-org-4107	1344	4	.	.	.
en-wikipedia-org-4107	1345	1	PMID	PMID	NNP
en-wikipedia-org-4107	1345	2	 	  	_SP
en-wikipedia-org-4107	1345	3	30586362	30586362	CD
en-wikipedia-org-4107	1345	4	.	.	.
en-wikipedia-org-4107	1346	1	^	^	NNP
en-wikipedia-org-4107	1346	2	a	a	DT
en-wikipedia-org-4107	1346	3	b	b	NN
en-wikipedia-org-4107	1346	4	c	c	NN
en-wikipedia-org-4107	1346	5	Carroll	Carroll	NNP
en-wikipedia-org-4107	1346	6	ME	ME	NNP
en-wikipedia-org-4107	1346	7	,	,	,
en-wikipedia-org-4107	1346	8	Smethells	Smethells	NNP
en-wikipedia-org-4107	1346	9	JR	JR	NNP
en-wikipedia-org-4107	1346	10	(	(	-LRB-
en-wikipedia-org-4107	1346	11	February	February	NNP
en-wikipedia-org-4107	1346	12	2016	2016	CD
en-wikipedia-org-4107	1346	13	)	)	-RRB-
en-wikipedia-org-4107	1346	14	.	.	.
en-wikipedia-org-4107	1347	1	"	"	``
en-wikipedia-org-4107	1347	2	Sex	sex	NN
en-wikipedia-org-4107	1347	3	Differences	difference	NNS
en-wikipedia-org-4107	1347	4	in	in	IN
en-wikipedia-org-4107	1347	5	Behavioral	Behavioral	NNP
en-wikipedia-org-4107	1347	6	Dyscontrol	Dyscontrol	NNP
en-wikipedia-org-4107	1347	7	:	:	:
en-wikipedia-org-4107	1347	8	Role	Role	NNP
en-wikipedia-org-4107	1347	9	in	in	IN
en-wikipedia-org-4107	1347	10	Drug	Drug	NNP
en-wikipedia-org-4107	1347	11	Addiction	Addiction	NNP
en-wikipedia-org-4107	1347	12	and	and	CC
en-wikipedia-org-4107	1347	13	Novel	Novel	NNP
en-wikipedia-org-4107	1347	14	Treatments	Treatments	NNPS
en-wikipedia-org-4107	1347	15	"	"	''
en-wikipedia-org-4107	1347	16	.	.	.
en-wikipedia-org-4107	1348	1	Frontiers	frontier	NNS
en-wikipedia-org-4107	1348	2	in	in	IN
en-wikipedia-org-4107	1348	3	Psychiatry	Psychiatry	NNP
en-wikipedia-org-4107	1348	4	.	.	.
en-wikipedia-org-4107	1349	1	6	6	CD
en-wikipedia-org-4107	1349	2	:	:	SYM
en-wikipedia-org-4107	1349	3	175	175	CD
en-wikipedia-org-4107	1349	4	.	.	.
en-wikipedia-org-4107	1349	5	doi:10.3389	doi:10.3389	NNP
en-wikipedia-org-4107	1349	6	/	/	SYM
en-wikipedia-org-4107	1349	7	fpsyt.2015.00175	fpsyt.2015.00175	JJ
en-wikipedia-org-4107	1349	8	.	.	.
en-wikipedia-org-4107	1350	1	PMC	PMC	NNP
en-wikipedia-org-4107	1350	2	 	  	_SP
en-wikipedia-org-4107	1350	3	4745113	4745113	CD
en-wikipedia-org-4107	1350	4	.	.	.
en-wikipedia-org-4107	1351	1	PMID	PMID	NNP
en-wikipedia-org-4107	1351	2	 	  	_SP
en-wikipedia-org-4107	1351	3	26903885	26903885	CD
en-wikipedia-org-4107	1351	4	.	.	.
en-wikipedia-org-4107	1352	1	Physical	Physical	NNP
en-wikipedia-org-4107	1352	2	Exercise	Exercise	NNP
en-wikipedia-org-4107	1352	3	There	there	EX
en-wikipedia-org-4107	1352	4	is	be	VBZ
en-wikipedia-org-4107	1352	5	accelerating	accelerate	VBG
en-wikipedia-org-4107	1352	6	evidence	evidence	NN
en-wikipedia-org-4107	1352	7	that	that	IN
en-wikipedia-org-4107	1352	8	physical	physical	JJ
en-wikipedia-org-4107	1352	9	exercise	exercise	NN
en-wikipedia-org-4107	1352	10	is	be	VBZ
en-wikipedia-org-4107	1352	11	a	a	DT
en-wikipedia-org-4107	1352	12	useful	useful	JJ
en-wikipedia-org-4107	1352	13	treatment	treatment	NN
en-wikipedia-org-4107	1352	14	for	for	IN
en-wikipedia-org-4107	1352	15	preventing	prevent	VBG
en-wikipedia-org-4107	1352	16	and	and	CC
en-wikipedia-org-4107	1352	17	reducing	reduce	VBG
en-wikipedia-org-4107	1352	18	drug	drug	NN
en-wikipedia-org-4107	1352	19	addiction	addiction	NN
en-wikipedia-org-4107	1352	20	 	  	_SP
en-wikipedia-org-4107	1352	21	...	...	.
en-wikipedia-org-4107	1353	1	In	in	IN
en-wikipedia-org-4107	1353	2	some	some	DT
en-wikipedia-org-4107	1353	3	individuals	individual	NNS
en-wikipedia-org-4107	1353	4	,	,	,
en-wikipedia-org-4107	1353	5	exercise	exercise	NN
en-wikipedia-org-4107	1353	6	has	have	VBZ
en-wikipedia-org-4107	1353	7	its	-PRON-	PRP$
en-wikipedia-org-4107	1353	8	own	own	JJ
en-wikipedia-org-4107	1353	9	rewarding	rewarding	JJ
en-wikipedia-org-4107	1353	10	effects	effect	NNS
en-wikipedia-org-4107	1353	11	,	,	,
en-wikipedia-org-4107	1353	12	and	and	CC
en-wikipedia-org-4107	1353	13	a	a	DT
en-wikipedia-org-4107	1353	14	behavioral	behavioral	JJ
en-wikipedia-org-4107	1353	15	economic	economic	JJ
en-wikipedia-org-4107	1353	16	interaction	interaction	NN
en-wikipedia-org-4107	1353	17	may	may	MD
en-wikipedia-org-4107	1353	18	occur	occur	VB
en-wikipedia-org-4107	1353	19	,	,	,
en-wikipedia-org-4107	1353	20	such	such	JJ
en-wikipedia-org-4107	1353	21	that	that	IN
en-wikipedia-org-4107	1353	22	physical	physical	JJ
en-wikipedia-org-4107	1353	23	and	and	CC
en-wikipedia-org-4107	1353	24	social	social	JJ
en-wikipedia-org-4107	1353	25	rewards	reward	NNS
en-wikipedia-org-4107	1353	26	of	of	IN
en-wikipedia-org-4107	1353	27	exercise	exercise	NN
en-wikipedia-org-4107	1353	28	can	can	MD
en-wikipedia-org-4107	1353	29	substitute	substitute	VB
en-wikipedia-org-4107	1353	30	for	for	IN
en-wikipedia-org-4107	1353	31	the	the	DT
en-wikipedia-org-4107	1353	32	rewarding	rewarding	JJ
en-wikipedia-org-4107	1353	33	effects	effect	NNS
en-wikipedia-org-4107	1353	34	of	of	IN
en-wikipedia-org-4107	1353	35	drug	drug	NN
en-wikipedia-org-4107	1353	36	abuse	abuse	NN
en-wikipedia-org-4107	1353	37	.	.	.
en-wikipedia-org-4107	1354	1	...	...	NFP
en-wikipedia-org-4107	1355	1	The	the	DT
en-wikipedia-org-4107	1355	2	value	value	NN
en-wikipedia-org-4107	1355	3	of	of	IN
en-wikipedia-org-4107	1355	4	this	this	DT
en-wikipedia-org-4107	1355	5	form	form	NN
en-wikipedia-org-4107	1355	6	of	of	IN
en-wikipedia-org-4107	1355	7	treatment	treatment	NN
en-wikipedia-org-4107	1355	8	for	for	IN
en-wikipedia-org-4107	1355	9	drug	drug	NN
en-wikipedia-org-4107	1355	10	addiction	addiction	NN
en-wikipedia-org-4107	1355	11	in	in	IN
en-wikipedia-org-4107	1355	12	laboratory	laboratory	NN
en-wikipedia-org-4107	1355	13	animals	animal	NNS
en-wikipedia-org-4107	1355	14	and	and	CC
en-wikipedia-org-4107	1355	15	humans	human	NNS
en-wikipedia-org-4107	1355	16	is	be	VBZ
en-wikipedia-org-4107	1355	17	that	that	DT
en-wikipedia-org-4107	1355	18	exercise	exercise	NN
en-wikipedia-org-4107	1355	19	,	,	,
en-wikipedia-org-4107	1355	20	if	if	IN
en-wikipedia-org-4107	1355	21	it	-PRON-	PRP
en-wikipedia-org-4107	1355	22	can	can	MD
en-wikipedia-org-4107	1355	23	substitute	substitute	VB
en-wikipedia-org-4107	1355	24	for	for	IN
en-wikipedia-org-4107	1355	25	the	the	DT
en-wikipedia-org-4107	1355	26	rewarding	rewarding	JJ
en-wikipedia-org-4107	1355	27	effects	effect	NNS
en-wikipedia-org-4107	1355	28	of	of	IN
en-wikipedia-org-4107	1355	29	drugs	drug	NNS
en-wikipedia-org-4107	1355	30	,	,	,
en-wikipedia-org-4107	1355	31	could	could	MD
en-wikipedia-org-4107	1355	32	be	be	VB
en-wikipedia-org-4107	1355	33	self	self	NN
en-wikipedia-org-4107	1355	34	-	-	HYPH
en-wikipedia-org-4107	1355	35	maintained	maintain	VBN
en-wikipedia-org-4107	1355	36	over	over	IN
en-wikipedia-org-4107	1355	37	an	an	DT
en-wikipedia-org-4107	1355	38	extended	extended	JJ
en-wikipedia-org-4107	1355	39	period	period	NN
en-wikipedia-org-4107	1355	40	of	of	IN
en-wikipedia-org-4107	1355	41	time	time	NN
en-wikipedia-org-4107	1355	42	.	.	.
en-wikipedia-org-4107	1356	1	Work	work	NN
en-wikipedia-org-4107	1356	2	to	to	IN
en-wikipedia-org-4107	1356	3	date	date	NN
en-wikipedia-org-4107	1356	4	in	in	IN
en-wikipedia-org-4107	1356	5	[	[	-LRB-
en-wikipedia-org-4107	1356	6	laboratory	laboratory	NN
en-wikipedia-org-4107	1356	7	animals	animal	NNS
en-wikipedia-org-4107	1356	8	and	and	CC
en-wikipedia-org-4107	1356	9	humans	human	NNS
en-wikipedia-org-4107	1356	10	]	]	-RRB-
en-wikipedia-org-4107	1356	11	regarding	regard	VBG
en-wikipedia-org-4107	1356	12	exercise	exercise	NN
en-wikipedia-org-4107	1356	13	as	as	IN
en-wikipedia-org-4107	1356	14	a	a	DT
en-wikipedia-org-4107	1356	15	treatment	treatment	NN
en-wikipedia-org-4107	1356	16	for	for	IN
en-wikipedia-org-4107	1356	17	drug	drug	NN
en-wikipedia-org-4107	1356	18	addiction	addiction	NN
en-wikipedia-org-4107	1356	19	supports	support	VBZ
en-wikipedia-org-4107	1356	20	this	this	DT
en-wikipedia-org-4107	1356	21	hypothesis	hypothesis	NN
en-wikipedia-org-4107	1356	22	.	.	.
en-wikipedia-org-4107	1357	1	...	...	NFP
en-wikipedia-org-4107	1358	1	Animal	animal	NN
en-wikipedia-org-4107	1358	2	and	and	CC
en-wikipedia-org-4107	1358	3	human	human	JJ
en-wikipedia-org-4107	1358	4	research	research	NN
en-wikipedia-org-4107	1358	5	on	on	IN
en-wikipedia-org-4107	1358	6	physical	physical	JJ
en-wikipedia-org-4107	1358	7	exercise	exercise	NN
en-wikipedia-org-4107	1358	8	as	as	IN
en-wikipedia-org-4107	1358	9	a	a	DT
en-wikipedia-org-4107	1358	10	treatment	treatment	NN
en-wikipedia-org-4107	1358	11	for	for	IN
en-wikipedia-org-4107	1358	12	stimulant	stimulant	JJ
en-wikipedia-org-4107	1358	13	addiction	addiction	NN
en-wikipedia-org-4107	1358	14	indicates	indicate	VBZ
en-wikipedia-org-4107	1358	15	that	that	IN
en-wikipedia-org-4107	1358	16	this	this	DT
en-wikipedia-org-4107	1358	17	is	be	VBZ
en-wikipedia-org-4107	1358	18	one	one	CD
en-wikipedia-org-4107	1358	19	of	of	IN
en-wikipedia-org-4107	1358	20	the	the	DT
en-wikipedia-org-4107	1358	21	most	most	RBS
en-wikipedia-org-4107	1358	22	promising	promising	JJ
en-wikipedia-org-4107	1358	23	treatments	treatment	NNS
en-wikipedia-org-4107	1358	24	on	on	IN
en-wikipedia-org-4107	1358	25	the	the	DT
en-wikipedia-org-4107	1358	26	horizon	horizon	NN
en-wikipedia-org-4107	1358	27	.	.	.
en-wikipedia-org-4107	1359	1	^	^	NNP
en-wikipedia-org-4107	1359	2	Perez	Perez	NNP
en-wikipedia-org-4107	1359	3	-	-	HYPH
en-wikipedia-org-4107	1359	4	Mana	Mana	NNP
en-wikipedia-org-4107	1359	5	C	C	NNP
en-wikipedia-org-4107	1359	6	,	,	,
en-wikipedia-org-4107	1359	7	Castells	Castells	NNP
en-wikipedia-org-4107	1359	8	X	X	NNP
en-wikipedia-org-4107	1359	9	,	,	,
en-wikipedia-org-4107	1359	10	Torrens	Torrens	NNP
en-wikipedia-org-4107	1359	11	M	M	NNP
en-wikipedia-org-4107	1359	12	,	,	,
en-wikipedia-org-4107	1359	13	Capella	Capella	NNP
en-wikipedia-org-4107	1359	14	D	d	NN
en-wikipedia-org-4107	1359	15	,	,	,
en-wikipedia-org-4107	1359	16	Farre	Farre	NNP
en-wikipedia-org-4107	1359	17	M	M	NNP
en-wikipedia-org-4107	1359	18	(	(	-LRB-
en-wikipedia-org-4107	1359	19	September	September	NNP
en-wikipedia-org-4107	1359	20	2013	2013	CD
en-wikipedia-org-4107	1359	21	)	)	-RRB-
en-wikipedia-org-4107	1359	22	.	.	.
en-wikipedia-org-4107	1360	1	"	"	``
en-wikipedia-org-4107	1360	2	Efficacy	efficacy	NN
en-wikipedia-org-4107	1360	3	of	of	IN
en-wikipedia-org-4107	1360	4	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	1360	5	drugs	drug	NNS
en-wikipedia-org-4107	1360	6	for	for	IN
en-wikipedia-org-4107	1360	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1360	8	abuse	abuse	NN
en-wikipedia-org-4107	1360	9	or	or	CC
en-wikipedia-org-4107	1360	10	dependence	dependence	NN
en-wikipedia-org-4107	1360	11	"	"	''
en-wikipedia-org-4107	1360	12	.	.	.
en-wikipedia-org-4107	1361	1	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	1361	2	Database	Database	NNP
en-wikipedia-org-4107	1361	3	of	of	IN
en-wikipedia-org-4107	1361	4	Systematic	Systematic	NNP
en-wikipedia-org-4107	1361	5	Reviews	Reviews	NNPS
en-wikipedia-org-4107	1361	6	.	.	.
en-wikipedia-org-4107	1362	1	9	9	CD
en-wikipedia-org-4107	1362	2	(	(	-LRB-
en-wikipedia-org-4107	1362	3	9	9	CD
en-wikipedia-org-4107	1362	4	)	)	-RRB-
en-wikipedia-org-4107	1362	5	:	:	:
en-wikipedia-org-4107	1362	6	CD009695	CD009695	NNP
en-wikipedia-org-4107	1362	7	.	.	.
en-wikipedia-org-4107	1363	1	doi:10.1002/14651858.CD009695.pub2	doi:10.1002/14651858.cd009695.pub2	UH
en-wikipedia-org-4107	1363	2	.	.	.
en-wikipedia-org-4107	1364	1	PMID	PMID	NNP
en-wikipedia-org-4107	1364	2	 	  	_SP
en-wikipedia-org-4107	1364	3	23996457	23996457	CD
en-wikipedia-org-4107	1364	4	.	.	.
en-wikipedia-org-4107	1365	1	^	^	FW
en-wikipedia-org-4107	1365	2	"	"	``
en-wikipedia-org-4107	1365	3	Amphetamines	amphetamine	NNS
en-wikipedia-org-4107	1365	4	:	:	:
en-wikipedia-org-4107	1365	5	Drug	Drug	NNP
en-wikipedia-org-4107	1365	6	Use	Use	NNP
en-wikipedia-org-4107	1365	7	and	and	CC
en-wikipedia-org-4107	1365	8	Abuse	Abuse	NNP
en-wikipedia-org-4107	1365	9	"	"	''
en-wikipedia-org-4107	1365	10	.	.	.
en-wikipedia-org-4107	1366	1	Merck	Merck	NNP
en-wikipedia-org-4107	1366	2	Manual	Manual	NNP
en-wikipedia-org-4107	1366	3	Home	Home	NNP
en-wikipedia-org-4107	1366	4	Edition	Edition	NNP
en-wikipedia-org-4107	1366	5	.	.	.
en-wikipedia-org-4107	1367	1	Merck	Merck	NNP
en-wikipedia-org-4107	1367	2	.	.	.
en-wikipedia-org-4107	1368	1	February	February	NNP
en-wikipedia-org-4107	1368	2	2003	2003	CD
en-wikipedia-org-4107	1368	3	.	.	.
en-wikipedia-org-4107	1369	1	Archived	archived	JJ
en-wikipedia-org-4107	1369	2	from	from	IN
en-wikipedia-org-4107	1369	3	the	the	DT
en-wikipedia-org-4107	1369	4	original	original	NN
en-wikipedia-org-4107	1369	5	on	on	IN
en-wikipedia-org-4107	1369	6	17	17	CD
en-wikipedia-org-4107	1369	7	February	February	NNP
en-wikipedia-org-4107	1369	8	2007	2007	CD
en-wikipedia-org-4107	1369	9	.	.	.
en-wikipedia-org-4107	1370	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1370	2	28	28	CD
en-wikipedia-org-4107	1370	3	February	February	NNP
en-wikipedia-org-4107	1370	4	2007	2007	CD
en-wikipedia-org-4107	1370	5	.	.	.
en-wikipedia-org-4107	1371	1	^	^	NNP
en-wikipedia-org-4107	1371	2	a	a	DT
en-wikipedia-org-4107	1371	3	b	b	NN
en-wikipedia-org-4107	1371	4	c	c	NN
en-wikipedia-org-4107	1371	5	d	d	NN
en-wikipedia-org-4107	1371	6	Shoptaw	Shoptaw	NNP
en-wikipedia-org-4107	1371	7	SJ	SJ	NNP
en-wikipedia-org-4107	1371	8	,	,	,
en-wikipedia-org-4107	1371	9	Kao	Kao	NNP
en-wikipedia-org-4107	1371	10	U	U	NNP
en-wikipedia-org-4107	1371	11	,	,	,
en-wikipedia-org-4107	1371	12	Heinzerling	heinzerle	VBG
en-wikipedia-org-4107	1371	13	K	K	NNP
en-wikipedia-org-4107	1371	14	,	,	,
en-wikipedia-org-4107	1371	15	Ling	Ling	NNP
en-wikipedia-org-4107	1371	16	W	W	NNP
en-wikipedia-org-4107	1371	17	(	(	-LRB-
en-wikipedia-org-4107	1371	18	April	April	NNP
en-wikipedia-org-4107	1371	19	2009	2009	CD
en-wikipedia-org-4107	1371	20	)	)	-RRB-
en-wikipedia-org-4107	1371	21	.	.	.
en-wikipedia-org-4107	1372	1	Shoptaw	Shoptaw	NNP
en-wikipedia-org-4107	1372	2	SJ	SJ	NNP
en-wikipedia-org-4107	1372	3	(	(	-LRB-
en-wikipedia-org-4107	1372	4	ed	ed	NNP
en-wikipedia-org-4107	1372	5	.	.	.
en-wikipedia-org-4107	1372	6	)	)	-RRB-
en-wikipedia-org-4107	1372	7	.	.	.
en-wikipedia-org-4107	1373	1	"	"	``
en-wikipedia-org-4107	1373	2	Treatment	treatment	NN
en-wikipedia-org-4107	1373	3	for	for	IN
en-wikipedia-org-4107	1373	4	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1373	5	withdrawal	withdrawal	NN
en-wikipedia-org-4107	1373	6	"	"	''
en-wikipedia-org-4107	1373	7	.	.	.
en-wikipedia-org-4107	1374	1	Cochrane	Cochrane	NNP
en-wikipedia-org-4107	1374	2	Database	Database	NNP
en-wikipedia-org-4107	1374	3	of	of	IN
en-wikipedia-org-4107	1374	4	Systematic	Systematic	NNP
en-wikipedia-org-4107	1374	5	Reviews	Reviews	NNPS
en-wikipedia-org-4107	1374	6	(	(	-LRB-
en-wikipedia-org-4107	1374	7	2	2	CD
en-wikipedia-org-4107	1374	8	)	)	-RRB-
en-wikipedia-org-4107	1374	9	:	:	:
en-wikipedia-org-4107	1374	10	CD003021	cd003021	ADD
en-wikipedia-org-4107	1374	11	.	.	.
en-wikipedia-org-4107	1375	1	doi:10.1002/14651858.CD003021.pub2	doi:10.1002/14651858.cd003021.pub2	UH
en-wikipedia-org-4107	1375	2	.	.	.
en-wikipedia-org-4107	1376	1	PMC	PMC	NNP
en-wikipedia-org-4107	1376	2	 	  	_SP
en-wikipedia-org-4107	1376	3	7138250	7138250	CD
en-wikipedia-org-4107	1376	4	.	.	.
en-wikipedia-org-4107	1377	1	PMID	PMID	NNP
en-wikipedia-org-4107	1377	2	 	  	_SP
en-wikipedia-org-4107	1377	3	19370579	19370579	CD
en-wikipedia-org-4107	1377	4	.	.	.
en-wikipedia-org-4107	1378	1	The	the	DT
en-wikipedia-org-4107	1378	2	prevalence	prevalence	NN
en-wikipedia-org-4107	1378	3	of	of	IN
en-wikipedia-org-4107	1378	4	this	this	DT
en-wikipedia-org-4107	1378	5	withdrawal	withdrawal	NN
en-wikipedia-org-4107	1378	6	syndrome	syndrome	NN
en-wikipedia-org-4107	1378	7	is	be	VBZ
en-wikipedia-org-4107	1378	8	extremely	extremely	RB
en-wikipedia-org-4107	1378	9	common	common	JJ
en-wikipedia-org-4107	1378	10	(	(	-LRB-
en-wikipedia-org-4107	1378	11	Cantwell	Cantwell	NNP
en-wikipedia-org-4107	1378	12	1998	1998	CD
en-wikipedia-org-4107	1378	13	;	;	:
en-wikipedia-org-4107	1378	14	Gossop	Gossop	NNP
en-wikipedia-org-4107	1378	15	1982	1982	CD
en-wikipedia-org-4107	1378	16	)	)	-RRB-
en-wikipedia-org-4107	1378	17	with	with	IN
en-wikipedia-org-4107	1378	18	87.6	87.6	CD
en-wikipedia-org-4107	1378	19	%	%	NN
en-wikipedia-org-4107	1378	20	of	of	IN
en-wikipedia-org-4107	1378	21	647	647	CD
en-wikipedia-org-4107	1378	22	individuals	individual	NNS
en-wikipedia-org-4107	1378	23	with	with	IN
en-wikipedia-org-4107	1378	24	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1378	25	dependence	dependence	NN
en-wikipedia-org-4107	1378	26	reporting	report	VBG
en-wikipedia-org-4107	1378	27	six	six	CD
en-wikipedia-org-4107	1378	28	or	or	CC
en-wikipedia-org-4107	1378	29	more	more	JJR
en-wikipedia-org-4107	1378	30	signs	sign	NNS
en-wikipedia-org-4107	1378	31	of	of	IN
en-wikipedia-org-4107	1378	32	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1378	33	withdrawal	withdrawal	NN
en-wikipedia-org-4107	1378	34	listed	list	VBN
en-wikipedia-org-4107	1378	35	in	in	IN
en-wikipedia-org-4107	1378	36	the	the	DT
en-wikipedia-org-4107	1378	37	DSM	DSM	NNP
en-wikipedia-org-4107	1378	38	when	when	WRB
en-wikipedia-org-4107	1378	39	the	the	DT
en-wikipedia-org-4107	1378	40	drug	drug	NN
en-wikipedia-org-4107	1378	41	is	be	VBZ
en-wikipedia-org-4107	1378	42	not	not	RB
en-wikipedia-org-4107	1378	43	available	available	JJ
en-wikipedia-org-4107	1378	44	(	(	-LRB-
en-wikipedia-org-4107	1378	45	Schuckit	schuckit	JJ
en-wikipedia-org-4107	1378	46	1999	1999	CD
en-wikipedia-org-4107	1378	47	)	)	-RRB-
en-wikipedia-org-4107	1378	48	 	  	_SP
en-wikipedia-org-4107	1378	49	...	...	:
en-wikipedia-org-4107	1379	1	The	the	DT
en-wikipedia-org-4107	1379	2	severity	severity	NN
en-wikipedia-org-4107	1379	3	of	of	IN
en-wikipedia-org-4107	1379	4	withdrawal	withdrawal	NN
en-wikipedia-org-4107	1379	5	symptoms	symptom	NNS
en-wikipedia-org-4107	1379	6	is	be	VBZ
en-wikipedia-org-4107	1379	7	greater	great	JJR
en-wikipedia-org-4107	1379	8	in	in	IN
en-wikipedia-org-4107	1379	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1379	10	dependent	dependent	JJ
en-wikipedia-org-4107	1379	11	individuals	individual	NNS
en-wikipedia-org-4107	1379	12	who	who	WP
en-wikipedia-org-4107	1379	13	are	be	VBP
en-wikipedia-org-4107	1379	14	older	old	JJR
en-wikipedia-org-4107	1379	15	and	and	CC
en-wikipedia-org-4107	1379	16	who	who	WP
en-wikipedia-org-4107	1379	17	have	have	VBP
en-wikipedia-org-4107	1379	18	more	more	RBR
en-wikipedia-org-4107	1379	19	extensive	extensive	JJ
en-wikipedia-org-4107	1379	20	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1379	21	use	use	NN
en-wikipedia-org-4107	1379	22	disorders	disorder	NNS
en-wikipedia-org-4107	1379	23	(	(	-LRB-
en-wikipedia-org-4107	1379	24	McGregor	McGregor	NNP
en-wikipedia-org-4107	1379	25	2005	2005	CD
en-wikipedia-org-4107	1379	26	)	)	-RRB-
en-wikipedia-org-4107	1379	27	.	.	.
en-wikipedia-org-4107	1380	1	Withdrawal	withdrawal	NN
en-wikipedia-org-4107	1380	2	symptoms	symptom	NNS
en-wikipedia-org-4107	1380	3	typically	typically	RB
en-wikipedia-org-4107	1380	4	present	present	JJ
en-wikipedia-org-4107	1380	5	within	within	IN
en-wikipedia-org-4107	1380	6	24	24	CD
en-wikipedia-org-4107	1380	7	 	  	_SP
en-wikipedia-org-4107	1380	8	hours	hour	NNS
en-wikipedia-org-4107	1380	9	of	of	IN
en-wikipedia-org-4107	1380	10	the	the	DT
en-wikipedia-org-4107	1380	11	last	last	JJ
en-wikipedia-org-4107	1380	12	use	use	NN
en-wikipedia-org-4107	1380	13	of	of	IN
en-wikipedia-org-4107	1380	14	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1380	15	,	,	,
en-wikipedia-org-4107	1380	16	with	with	IN
en-wikipedia-org-4107	1380	17	a	a	DT
en-wikipedia-org-4107	1380	18	withdrawal	withdrawal	NN
en-wikipedia-org-4107	1380	19	syndrome	syndrome	NN
en-wikipedia-org-4107	1380	20	involving	involve	VBG
en-wikipedia-org-4107	1380	21	two	two	CD
en-wikipedia-org-4107	1380	22	general	general	JJ
en-wikipedia-org-4107	1380	23	phases	phase	NNS
en-wikipedia-org-4107	1380	24	that	that	WDT
en-wikipedia-org-4107	1380	25	can	can	MD
en-wikipedia-org-4107	1380	26	last	last	VB
en-wikipedia-org-4107	1380	27	3	3	CD
en-wikipedia-org-4107	1380	28	weeks	week	NNS
en-wikipedia-org-4107	1380	29	or	or	CC
en-wikipedia-org-4107	1380	30	more	more	JJR
en-wikipedia-org-4107	1380	31	.	.	.
en-wikipedia-org-4107	1381	1	The	the	DT
en-wikipedia-org-4107	1381	2	first	first	JJ
en-wikipedia-org-4107	1381	3	phase	phase	NN
en-wikipedia-org-4107	1381	4	of	of	IN
en-wikipedia-org-4107	1381	5	this	this	DT
en-wikipedia-org-4107	1381	6	syndrome	syndrome	NN
en-wikipedia-org-4107	1381	7	is	be	VBZ
en-wikipedia-org-4107	1381	8	the	the	DT
en-wikipedia-org-4107	1381	9	initial	initial	JJ
en-wikipedia-org-4107	1381	10	"	"	``
en-wikipedia-org-4107	1381	11	crash	crash	NN
en-wikipedia-org-4107	1381	12	"	"	''
en-wikipedia-org-4107	1381	13	that	that	WDT
en-wikipedia-org-4107	1381	14	resolves	resolve	VBZ
en-wikipedia-org-4107	1381	15	within	within	IN
en-wikipedia-org-4107	1381	16	about	about	RB
en-wikipedia-org-4107	1381	17	a	a	DT
en-wikipedia-org-4107	1381	18	week	week	NN
en-wikipedia-org-4107	1381	19	(	(	-LRB-
en-wikipedia-org-4107	1381	20	Gossop	Gossop	NNP
en-wikipedia-org-4107	1381	21	1982;McGregor	1982;McGregor	VBD
en-wikipedia-org-4107	1381	22	2005	2005	CD
en-wikipedia-org-4107	1381	23	)	)	-RRB-
en-wikipedia-org-4107	1381	24	 	  	_SP
en-wikipedia-org-4107	1381	25	...	...	:
en-wikipedia-org-4107	1381	26	^	^	NNP
en-wikipedia-org-4107	1381	27	a	a	DT
en-wikipedia-org-4107	1381	28	b	b	NN
en-wikipedia-org-4107	1381	29	Spiller	Spiller	NNP
en-wikipedia-org-4107	1381	30	HA	HA	NNP
en-wikipedia-org-4107	1381	31	,	,	,
en-wikipedia-org-4107	1381	32	Hays	Hays	NNP
en-wikipedia-org-4107	1381	33	HL	HL	NNP
en-wikipedia-org-4107	1381	34	,	,	,
en-wikipedia-org-4107	1381	35	Aleguas	Aleguas	NNP
en-wikipedia-org-4107	1381	36	A	A	NNP
en-wikipedia-org-4107	1381	37	(	(	-LRB-
en-wikipedia-org-4107	1381	38	June	June	NNP
en-wikipedia-org-4107	1381	39	2013	2013	CD
en-wikipedia-org-4107	1381	40	)	)	-RRB-
en-wikipedia-org-4107	1381	41	.	.	.
en-wikipedia-org-4107	1382	1	"	"	``
en-wikipedia-org-4107	1382	2	Overdose	overdose	NN
en-wikipedia-org-4107	1382	3	of	of	IN
en-wikipedia-org-4107	1382	4	drugs	drug	NNS
en-wikipedia-org-4107	1382	5	for	for	IN
en-wikipedia-org-4107	1382	6	attention	attention	NN
en-wikipedia-org-4107	1382	7	-	-	HYPH
en-wikipedia-org-4107	1382	8	deficit	deficit	NN
en-wikipedia-org-4107	1382	9	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	1382	10	disorder	disorder	NN
en-wikipedia-org-4107	1382	11	:	:	:
en-wikipedia-org-4107	1382	12	clinical	clinical	JJ
en-wikipedia-org-4107	1382	13	presentation	presentation	NN
en-wikipedia-org-4107	1382	14	,	,	,
en-wikipedia-org-4107	1382	15	mechanisms	mechanism	NNS
en-wikipedia-org-4107	1382	16	of	of	IN
en-wikipedia-org-4107	1382	17	toxicity	toxicity	NN
en-wikipedia-org-4107	1382	18	,	,	,
en-wikipedia-org-4107	1382	19	and	and	CC
en-wikipedia-org-4107	1382	20	management	management	NN
en-wikipedia-org-4107	1382	21	"	"	''
en-wikipedia-org-4107	1382	22	.	.	.
en-wikipedia-org-4107	1383	1	CNS	CNS	NNP
en-wikipedia-org-4107	1383	2	Drugs	drug	NNS
en-wikipedia-org-4107	1383	3	.	.	.
en-wikipedia-org-4107	1384	1	27	27	CD
en-wikipedia-org-4107	1384	2	(	(	-LRB-
en-wikipedia-org-4107	1384	3	7	7	CD
en-wikipedia-org-4107	1384	4	)	)	-RRB-
en-wikipedia-org-4107	1384	5	:	:	:
en-wikipedia-org-4107	1384	6	531–543	531–543	CD
en-wikipedia-org-4107	1384	7	.	.	.
en-wikipedia-org-4107	1385	1	doi:10.1007	doi:10.1007	NNP
en-wikipedia-org-4107	1385	2	/	/	SYM
en-wikipedia-org-4107	1385	3	s40263	s40263	NNP
en-wikipedia-org-4107	1385	4	-	-	HYPH
en-wikipedia-org-4107	1385	5	013	013	CD
en-wikipedia-org-4107	1385	6	-	-	HYPH
en-wikipedia-org-4107	1385	7	0084	0084	CD
en-wikipedia-org-4107	1385	8	-	-	HYPH
en-wikipedia-org-4107	1385	9	8	8	CD
en-wikipedia-org-4107	1385	10	.	.	.
en-wikipedia-org-4107	1386	1	PMID	PMID	NNP
en-wikipedia-org-4107	1386	2	 	  	_SP
en-wikipedia-org-4107	1386	3	23757186	23757186	CD
en-wikipedia-org-4107	1386	4	.	.	.
en-wikipedia-org-4107	1387	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1387	2	 	  	_SP
en-wikipedia-org-4107	1387	3	40931380	40931380	CD
en-wikipedia-org-4107	1387	4	.	.	.
en-wikipedia-org-4107	1388	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1388	2	,	,	,
en-wikipedia-org-4107	1388	3	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	1388	4	,	,	,
en-wikipedia-org-4107	1388	5	and	and	CC
en-wikipedia-org-4107	1388	6	methylphenidate	methylphenidate	VB
en-wikipedia-org-4107	1388	7	act	act	NNP
en-wikipedia-org-4107	1388	8	as	as	IN
en-wikipedia-org-4107	1388	9	substrates	substrate	NNS
en-wikipedia-org-4107	1388	10	for	for	IN
en-wikipedia-org-4107	1388	11	the	the	DT
en-wikipedia-org-4107	1388	12	cellular	cellular	JJ
en-wikipedia-org-4107	1388	13	monoamine	monoamine	NN
en-wikipedia-org-4107	1388	14	transporter	transporter	NN
en-wikipedia-org-4107	1388	15	,	,	,
en-wikipedia-org-4107	1388	16	especially	especially	RB
en-wikipedia-org-4107	1388	17	the	the	DT
en-wikipedia-org-4107	1388	18	dopamine	dopamine	NN
en-wikipedia-org-4107	1388	19	transporter	transporter	NN
en-wikipedia-org-4107	1388	20	(	(	-LRB-
en-wikipedia-org-4107	1388	21	DAT	DAT	NNP
en-wikipedia-org-4107	1388	22	)	)	-RRB-
en-wikipedia-org-4107	1388	23	and	and	CC
en-wikipedia-org-4107	1388	24	less	less	RBR
en-wikipedia-org-4107	1388	25	so	so	IN
en-wikipedia-org-4107	1388	26	the	the	DT
en-wikipedia-org-4107	1388	27	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	1388	28	(	(	-LRB-
en-wikipedia-org-4107	1388	29	NET	NET	NNP
en-wikipedia-org-4107	1388	30	)	)	-RRB-
en-wikipedia-org-4107	1388	31	and	and	CC
en-wikipedia-org-4107	1388	32	serotonin	serotonin	JJ
en-wikipedia-org-4107	1388	33	transporter	transporter	NN
en-wikipedia-org-4107	1388	34	.	.	.
en-wikipedia-org-4107	1389	1	The	the	DT
en-wikipedia-org-4107	1389	2	mechanism	mechanism	NN
en-wikipedia-org-4107	1389	3	of	of	IN
en-wikipedia-org-4107	1389	4	toxicity	toxicity	NN
en-wikipedia-org-4107	1389	5	is	be	VBZ
en-wikipedia-org-4107	1389	6	primarily	primarily	RB
en-wikipedia-org-4107	1389	7	related	related	JJ
en-wikipedia-org-4107	1389	8	to	to	IN
en-wikipedia-org-4107	1389	9	excessive	excessive	JJ
en-wikipedia-org-4107	1389	10	extracellular	extracellular	NNP
en-wikipedia-org-4107	1389	11	dopamine	dopamine	NN
en-wikipedia-org-4107	1389	12	,	,	,
en-wikipedia-org-4107	1389	13	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	1389	14	,	,	,
en-wikipedia-org-4107	1389	15	and	and	CC
en-wikipedia-org-4107	1389	16	serotonin	serotonin	NN
en-wikipedia-org-4107	1389	17	.	.	.
en-wikipedia-org-4107	1390	1	^	^	NFP
en-wikipedia-org-4107	1390	2	Collaborators	Collaborators	NNP
en-wikipedia-org-4107	1390	3	(	(	-LRB-
en-wikipedia-org-4107	1390	4	2015	2015	CD
en-wikipedia-org-4107	1390	5	)	)	-RRB-
en-wikipedia-org-4107	1390	6	.	.	.
en-wikipedia-org-4107	1391	1	"	"	``
en-wikipedia-org-4107	1391	2	Global	global	JJ
en-wikipedia-org-4107	1391	3	,	,	,
en-wikipedia-org-4107	1391	4	regional	regional	JJ
en-wikipedia-org-4107	1391	5	,	,	,
en-wikipedia-org-4107	1391	6	and	and	CC
en-wikipedia-org-4107	1391	7	national	national	JJ
en-wikipedia-org-4107	1391	8	age	age	NN
en-wikipedia-org-4107	1391	9	-	-	HYPH
en-wikipedia-org-4107	1391	10	sex	sex	NN
en-wikipedia-org-4107	1391	11	specific	specific	NN
en-wikipedia-org-4107	1391	12	all	all	RB
en-wikipedia-org-4107	1391	13	-	-	HYPH
en-wikipedia-org-4107	1391	14	cause	cause	NN
en-wikipedia-org-4107	1391	15	and	and	CC
en-wikipedia-org-4107	1391	16	cause	cause	NN
en-wikipedia-org-4107	1391	17	-	-	HYPH
en-wikipedia-org-4107	1391	18	specific	specific	JJ
en-wikipedia-org-4107	1391	19	mortality	mortality	NN
en-wikipedia-org-4107	1391	20	for	for	IN
en-wikipedia-org-4107	1391	21	240	240	CD
en-wikipedia-org-4107	1391	22	causes	cause	NNS
en-wikipedia-org-4107	1391	23	of	of	IN
en-wikipedia-org-4107	1391	24	death	death	NN
en-wikipedia-org-4107	1391	25	,	,	,
en-wikipedia-org-4107	1391	26	1990–2013	1990–2013	CD
en-wikipedia-org-4107	1391	27	:	:	:
en-wikipedia-org-4107	1391	28	a	a	DT
en-wikipedia-org-4107	1391	29	systematic	systematic	JJ
en-wikipedia-org-4107	1391	30	analysis	analysis	NN
en-wikipedia-org-4107	1391	31	for	for	IN
en-wikipedia-org-4107	1391	32	the	the	DT
en-wikipedia-org-4107	1391	33	Global	Global	NNP
en-wikipedia-org-4107	1391	34	Burden	Burden	NNP
en-wikipedia-org-4107	1391	35	of	of	IN
en-wikipedia-org-4107	1391	36	Disease	Disease	NNP
en-wikipedia-org-4107	1391	37	Study	Study	NNP
en-wikipedia-org-4107	1391	38	2013	2013	CD
en-wikipedia-org-4107	1391	39	"	"	''
en-wikipedia-org-4107	1391	40	(	(	-LRB-
en-wikipedia-org-4107	1391	41	PDF	PDF	NNP
en-wikipedia-org-4107	1391	42	)	)	-RRB-
en-wikipedia-org-4107	1391	43	.	.	.
en-wikipedia-org-4107	1392	1	The	the	DT
en-wikipedia-org-4107	1392	2	Lancet	Lancet	NNP
en-wikipedia-org-4107	1392	3	.	.	.
en-wikipedia-org-4107	1393	1	385	385	CD
en-wikipedia-org-4107	1393	2	(	(	-LRB-
en-wikipedia-org-4107	1393	3	9963	9963	CD
en-wikipedia-org-4107	1393	4	)	)	-RRB-
en-wikipedia-org-4107	1393	5	:	:	:
en-wikipedia-org-4107	1393	6	117–171	117–171	CD
en-wikipedia-org-4107	1393	7	.	.	.
en-wikipedia-org-4107	1394	1	doi:10.1016	doi:10.1016	JJ
en-wikipedia-org-4107	1394	2	/	/	SYM
en-wikipedia-org-4107	1394	3	S0140	S0140	NNP
en-wikipedia-org-4107	1394	4	-	-	HYPH
en-wikipedia-org-4107	1394	5	6736(14)61682	6736(14)61682	NNP
en-wikipedia-org-4107	1394	6	-	-	HYPH
en-wikipedia-org-4107	1394	7	2	2	CD
en-wikipedia-org-4107	1394	8	.	.	.
en-wikipedia-org-4107	1395	1	PMC	PMC	NNP
en-wikipedia-org-4107	1395	2	 	  	_SP
en-wikipedia-org-4107	1395	3	4340604	4340604	CD
en-wikipedia-org-4107	1395	4	.	.	.
en-wikipedia-org-4107	1396	1	PMID	PMID	NNP
en-wikipedia-org-4107	1396	2	 	  	_SP
en-wikipedia-org-4107	1396	3	25530442	25530442	CD
en-wikipedia-org-4107	1396	4	.	.	.
en-wikipedia-org-4107	1397	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1397	2	3	3	CD
en-wikipedia-org-4107	1397	3	March	March	NNP
en-wikipedia-org-4107	1397	4	2015	2015	CD
en-wikipedia-org-4107	1397	5	.	.	.
en-wikipedia-org-4107	1398	1	Amphetamine	amphetamine	VB
en-wikipedia-org-4107	1398	2	use	use	NN
en-wikipedia-org-4107	1398	3	disorders	disorder	VBZ
en-wikipedia-org-4107	1398	4	 	  	_SP
en-wikipedia-org-4107	1398	5	...	...	:
en-wikipedia-org-4107	1398	6	3,788	3,788	CD
en-wikipedia-org-4107	1398	7	 	  	_SP
en-wikipedia-org-4107	1398	8	(	(	-LRB-
en-wikipedia-org-4107	1398	9	3,425–4,145	3,425–4,145	CD
en-wikipedia-org-4107	1398	10	)	)	-RRB-
en-wikipedia-org-4107	1398	11	^	^	.
en-wikipedia-org-4107	1398	12	Albertson	Albertson	NNP
en-wikipedia-org-4107	1398	13	TE	TE	NNP
en-wikipedia-org-4107	1398	14	(	(	-LRB-
en-wikipedia-org-4107	1398	15	2011	2011	CD
en-wikipedia-org-4107	1398	16	)	)	-RRB-
en-wikipedia-org-4107	1398	17	.	.	.
en-wikipedia-org-4107	1399	1	"	"	``
en-wikipedia-org-4107	1399	2	Amphetamines	Amphetamines	NNPS
en-wikipedia-org-4107	1399	3	"	"	''
en-wikipedia-org-4107	1399	4	.	.	.
en-wikipedia-org-4107	1400	1	In	in	IN
en-wikipedia-org-4107	1400	2	Olson	Olson	NNP
en-wikipedia-org-4107	1400	3	KR	KR	NNP
en-wikipedia-org-4107	1400	4	,	,	,
en-wikipedia-org-4107	1400	5	Anderson	Anderson	NNP
en-wikipedia-org-4107	1400	6	IB	IB	NNP
en-wikipedia-org-4107	1400	7	,	,	,
en-wikipedia-org-4107	1400	8	Benowitz	Benowitz	NNP
en-wikipedia-org-4107	1400	9	NL	NL	NNP
en-wikipedia-org-4107	1400	10	,	,	,
en-wikipedia-org-4107	1400	11	Blanc	Blanc	NNP
en-wikipedia-org-4107	1400	12	PD	PD	NNP
en-wikipedia-org-4107	1400	13	,	,	,
en-wikipedia-org-4107	1400	14	Kearney	Kearney	NNP
en-wikipedia-org-4107	1400	15	TE	TE	NNP
en-wikipedia-org-4107	1400	16	,	,	,
en-wikipedia-org-4107	1400	17	Kim	Kim	NNP
en-wikipedia-org-4107	1400	18	-	-	HYPH
en-wikipedia-org-4107	1400	19	Katz	Katz	NNP
en-wikipedia-org-4107	1400	20	SY	SY	NNP
en-wikipedia-org-4107	1400	21	,	,	,
en-wikipedia-org-4107	1400	22	Wu	Wu	NNP
en-wikipedia-org-4107	1400	23	AH	AH	NNP
en-wikipedia-org-4107	1400	24	(	(	-LRB-
en-wikipedia-org-4107	1400	25	eds	eds	NNP
en-wikipedia-org-4107	1400	26	.	.	.
en-wikipedia-org-4107	1400	27	)	)	-RRB-
en-wikipedia-org-4107	1400	28	.	.	.
en-wikipedia-org-4107	1401	1	Poisoning	Poisoning	NNP
en-wikipedia-org-4107	1401	2	&	&	CC
en-wikipedia-org-4107	1401	3	Drug	Drug	NNP
en-wikipedia-org-4107	1401	4	Overdose	Overdose	NNP
en-wikipedia-org-4107	1401	5	(	(	-LRB-
en-wikipedia-org-4107	1401	6	6th	6th	JJ
en-wikipedia-org-4107	1401	7	ed	ed	NNP
en-wikipedia-org-4107	1401	8	.	.	.
en-wikipedia-org-4107	1401	9	)	)	-RRB-
en-wikipedia-org-4107	1401	10	.	.	.
en-wikipedia-org-4107	1402	1	New	New	NNP
en-wikipedia-org-4107	1402	2	York	York	NNP
en-wikipedia-org-4107	1402	3	:	:	:
en-wikipedia-org-4107	1402	4	McGraw	McGraw	NNP
en-wikipedia-org-4107	1402	5	-	-	HYPH
en-wikipedia-org-4107	1402	6	Hill	Hill	NNP
en-wikipedia-org-4107	1402	7	Medical	Medical	NNP
en-wikipedia-org-4107	1402	8	.	.	.
en-wikipedia-org-4107	1403	1	pp	pp	NNP
en-wikipedia-org-4107	1403	2	.	.	.
en-wikipedia-org-4107	1404	1	77–79	77–79	LS
en-wikipedia-org-4107	1404	2	.	.	.
en-wikipedia-org-4107	1405	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	1405	2	 	  	_SP
en-wikipedia-org-4107	1405	3	9780071668330	9780071668330	CD
en-wikipedia-org-4107	1405	4	.	.	.
en-wikipedia-org-4107	1406	1	^	^	:
en-wikipedia-org-4107	1406	2	Advokat	Advokat	NNP
en-wikipedia-org-4107	1406	3	C	C	NNP
en-wikipedia-org-4107	1406	4	(	(	-LRB-
en-wikipedia-org-4107	1406	5	July	July	NNP
en-wikipedia-org-4107	1406	6	2007	2007	CD
en-wikipedia-org-4107	1406	7	)	)	-RRB-
en-wikipedia-org-4107	1406	8	.	.	.
en-wikipedia-org-4107	1407	1	"	"	``
en-wikipedia-org-4107	1407	2	Update	update	VB
en-wikipedia-org-4107	1407	3	on	on	IN
en-wikipedia-org-4107	1407	4	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1407	5	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	1407	6	and	and	CC
en-wikipedia-org-4107	1407	7	its	-PRON-	PRP$
en-wikipedia-org-4107	1407	8	relevance	relevance	NN
en-wikipedia-org-4107	1407	9	to	to	IN
en-wikipedia-org-4107	1407	10	the	the	DT
en-wikipedia-org-4107	1407	11	treatment	treatment	NN
en-wikipedia-org-4107	1407	12	of	of	IN
en-wikipedia-org-4107	1407	13	ADHD	ADHD	NNP
en-wikipedia-org-4107	1407	14	"	"	''
en-wikipedia-org-4107	1407	15	.	.	.
en-wikipedia-org-4107	1408	1	Journal	Journal	NNP
en-wikipedia-org-4107	1408	2	of	of	IN
en-wikipedia-org-4107	1408	3	Attention	Attention	NNP
en-wikipedia-org-4107	1408	4	Disorders	Disorders	NNPS
en-wikipedia-org-4107	1408	5	.	.	.
en-wikipedia-org-4107	1409	1	11	11	CD
en-wikipedia-org-4107	1409	2	(	(	-LRB-
en-wikipedia-org-4107	1409	3	1	1	CD
en-wikipedia-org-4107	1409	4	)	)	-RRB-
en-wikipedia-org-4107	1409	5	:	:	:
en-wikipedia-org-4107	1409	6	8–16	8–16	CD
en-wikipedia-org-4107	1409	7	.	.	.
en-wikipedia-org-4107	1410	1	doi:10.1177/1087054706295605	doi:10.1177/1087054706295605	NNP
en-wikipedia-org-4107	1410	2	.	.	.
en-wikipedia-org-4107	1411	1	PMID	PMID	NNP
en-wikipedia-org-4107	1411	2	 	  	_SP
en-wikipedia-org-4107	1411	3	17606768	17606768	CD
en-wikipedia-org-4107	1411	4	.	.	.
en-wikipedia-org-4107	1412	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1412	2	 	  	_SP
en-wikipedia-org-4107	1412	3	7582744	7582744	CD
en-wikipedia-org-4107	1412	4	.	.	.
en-wikipedia-org-4107	1413	1	^	^	NNP
en-wikipedia-org-4107	1413	2	a	a	DT
en-wikipedia-org-4107	1413	3	b	b	NN
en-wikipedia-org-4107	1413	4	c	c	NN
en-wikipedia-org-4107	1413	5	d	d	NN
en-wikipedia-org-4107	1413	6	Bowyer	Bowyer	NNP
en-wikipedia-org-4107	1413	7	JF	JF	NNP
en-wikipedia-org-4107	1413	8	,	,	,
en-wikipedia-org-4107	1413	9	Hanig	Hanig	NNP
en-wikipedia-org-4107	1413	10	JP	JP	NNP
en-wikipedia-org-4107	1413	11	(	(	-LRB-
en-wikipedia-org-4107	1413	12	November	November	NNP
en-wikipedia-org-4107	1413	13	2014	2014	CD
en-wikipedia-org-4107	1413	14	)	)	-RRB-
en-wikipedia-org-4107	1413	15	.	.	.
en-wikipedia-org-4107	1414	1	"	"	``
en-wikipedia-org-4107	1414	2	Amphetamine-	Amphetamine-	NNP
en-wikipedia-org-4107	1414	3	and	and	CC
en-wikipedia-org-4107	1414	4	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	1414	5	-	-	HYPH
en-wikipedia-org-4107	1414	6	induced	induce	VBN
en-wikipedia-org-4107	1414	7	hyperthermia	hyperthermia	NN
en-wikipedia-org-4107	1414	8	:	:	:
en-wikipedia-org-4107	1414	9	Implications	implication	NNS
en-wikipedia-org-4107	1414	10	of	of	IN
en-wikipedia-org-4107	1414	11	the	the	DT
en-wikipedia-org-4107	1414	12	effects	effect	NNS
en-wikipedia-org-4107	1414	13	produced	produce	VBN
en-wikipedia-org-4107	1414	14	in	in	IN
en-wikipedia-org-4107	1414	15	brain	brain	NN
en-wikipedia-org-4107	1414	16	vasculature	vasculature	NN
en-wikipedia-org-4107	1414	17	and	and	CC
en-wikipedia-org-4107	1414	18	peripheral	peripheral	JJ
en-wikipedia-org-4107	1414	19	organs	organ	NNS
en-wikipedia-org-4107	1414	20	to	to	TO
en-wikipedia-org-4107	1414	21	forebrain	forebrain	VB
en-wikipedia-org-4107	1414	22	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	1414	23	"	"	''
en-wikipedia-org-4107	1414	24	.	.	.
en-wikipedia-org-4107	1415	1	Temperature	temperature	NN
en-wikipedia-org-4107	1415	2	.	.	.
en-wikipedia-org-4107	1416	1	1	1	CD
en-wikipedia-org-4107	1416	2	(	(	-LRB-
en-wikipedia-org-4107	1416	3	3	3	CD
en-wikipedia-org-4107	1416	4	)	)	-RRB-
en-wikipedia-org-4107	1416	5	:	:	:
en-wikipedia-org-4107	1416	6	172–182	172–182	CD
en-wikipedia-org-4107	1416	7	.	.	.
en-wikipedia-org-4107	1417	1	doi:10.4161/23328940.2014.982049	doi:10.4161/23328940.2014.982049	NNP
en-wikipedia-org-4107	1417	2	.	.	.
en-wikipedia-org-4107	1418	1	PMC	PMC	NNP
en-wikipedia-org-4107	1418	2	 	  	_SP
en-wikipedia-org-4107	1418	3	5008711	5008711	CD
en-wikipedia-org-4107	1418	4	.	.	.
en-wikipedia-org-4107	1419	1	PMID	PMID	NNP
en-wikipedia-org-4107	1419	2	 	  	_SP
en-wikipedia-org-4107	1419	3	27626044	27626044	CD
en-wikipedia-org-4107	1419	4	.	.	.
en-wikipedia-org-4107	1420	1	Hyperthermia	Hyperthermia	NNP
en-wikipedia-org-4107	1420	2	alone	alone	JJ
en-wikipedia-org-4107	1420	3	does	do	VBZ
en-wikipedia-org-4107	1420	4	not	not	RB
en-wikipedia-org-4107	1420	5	produce	produce	VB
en-wikipedia-org-4107	1420	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1420	7	-	-	HYPH
en-wikipedia-org-4107	1420	8	like	like	JJ
en-wikipedia-org-4107	1420	9	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	1420	10	but	but	CC
en-wikipedia-org-4107	1420	11	AMPH	AMPH	NNP
en-wikipedia-org-4107	1420	12	and	and	CC
en-wikipedia-org-4107	1420	13	METH	METH	NNP
en-wikipedia-org-4107	1420	14	exposures	exposure	NNS
en-wikipedia-org-4107	1420	15	that	that	WDT
en-wikipedia-org-4107	1420	16	do	do	VBP
en-wikipedia-org-4107	1420	17	not	not	RB
en-wikipedia-org-4107	1420	18	produce	produce	VB
en-wikipedia-org-4107	1420	19	hyperthermia	hyperthermia	NN
en-wikipedia-org-4107	1420	20	(	(	-LRB-
en-wikipedia-org-4107	1420	21	≥40	≥40	NNP
en-wikipedia-org-4107	1420	22	 	  	_SP
en-wikipedia-org-4107	1420	23	°	°	,
en-wikipedia-org-4107	1420	24	C	C	NNP
en-wikipedia-org-4107	1420	25	)	)	-RRB-
en-wikipedia-org-4107	1420	26	are	be	VBP
en-wikipedia-org-4107	1420	27	minimally	minimally	RB
en-wikipedia-org-4107	1420	28	neurotoxic	neurotoxic	JJ
en-wikipedia-org-4107	1420	29	.	.	.
en-wikipedia-org-4107	1421	1	Hyperthermia	Hyperthermia	NNP
en-wikipedia-org-4107	1421	2	likely	likely	RB
en-wikipedia-org-4107	1421	3	enhances	enhance	VBZ
en-wikipedia-org-4107	1421	4	AMPH	AMPH	NNP
en-wikipedia-org-4107	1421	5	and	and	CC
en-wikipedia-org-4107	1421	6	METH	METH	NNP
en-wikipedia-org-4107	1421	7	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	1421	8	directly	directly	RB
en-wikipedia-org-4107	1421	9	through	through	IN
en-wikipedia-org-4107	1421	10	disruption	disruption	NN
en-wikipedia-org-4107	1421	11	of	of	IN
en-wikipedia-org-4107	1421	12	protein	protein	NN
en-wikipedia-org-4107	1421	13	function	function	NN
en-wikipedia-org-4107	1421	14	,	,	,
en-wikipedia-org-4107	1421	15	ion	ion	NN
en-wikipedia-org-4107	1421	16	channels	channel	NNS
en-wikipedia-org-4107	1421	17	and	and	CC
en-wikipedia-org-4107	1421	18	enhanced	enhance	VBN
en-wikipedia-org-4107	1421	19	ROS	ROS	NNP
en-wikipedia-org-4107	1421	20	production	production	NN
en-wikipedia-org-4107	1421	21	.	.	.
en-wikipedia-org-4107	1422	1	...	...	NFP
en-wikipedia-org-4107	1423	1	The	the	DT
en-wikipedia-org-4107	1423	2	hyperthermia	hyperthermia	NN
en-wikipedia-org-4107	1423	3	and	and	CC
en-wikipedia-org-4107	1423	4	the	the	DT
en-wikipedia-org-4107	1423	5	hypertension	hypertension	NN
en-wikipedia-org-4107	1423	6	produced	produce	VBN
en-wikipedia-org-4107	1423	7	by	by	IN
en-wikipedia-org-4107	1423	8	high	high	JJ
en-wikipedia-org-4107	1423	9	doses	dose	NNS
en-wikipedia-org-4107	1423	10	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	1423	11	are	be	VBP
en-wikipedia-org-4107	1423	12	a	a	DT
en-wikipedia-org-4107	1423	13	primary	primary	JJ
en-wikipedia-org-4107	1423	14	cause	cause	NN
en-wikipedia-org-4107	1423	15	of	of	IN
en-wikipedia-org-4107	1423	16	transient	transient	JJ
en-wikipedia-org-4107	1423	17	breakdowns	breakdown	NNS
en-wikipedia-org-4107	1423	18	in	in	IN
en-wikipedia-org-4107	1423	19	the	the	DT
en-wikipedia-org-4107	1423	20	blood	blood	NN
en-wikipedia-org-4107	1423	21	-	-	HYPH
en-wikipedia-org-4107	1423	22	brain	brain	NN
en-wikipedia-org-4107	1423	23	barrier	barrier	NN
en-wikipedia-org-4107	1423	24	(	(	-LRB-
en-wikipedia-org-4107	1423	25	BBB	BBB	NNP
en-wikipedia-org-4107	1423	26	)	)	-RRB-
en-wikipedia-org-4107	1423	27	resulting	result	VBG
en-wikipedia-org-4107	1423	28	in	in	IN
en-wikipedia-org-4107	1423	29	concomitant	concomitant	JJ
en-wikipedia-org-4107	1423	30	regional	regional	JJ
en-wikipedia-org-4107	1423	31	neurodegeneration	neurodegeneration	NN
en-wikipedia-org-4107	1423	32	and	and	CC
en-wikipedia-org-4107	1423	33	neuroinflammation	neuroinflammation	NN
en-wikipedia-org-4107	1423	34	in	in	IN
en-wikipedia-org-4107	1423	35	laboratory	laboratory	NN
en-wikipedia-org-4107	1423	36	animals	animal	NNS
en-wikipedia-org-4107	1423	37	.	.	.
en-wikipedia-org-4107	1424	1	...	...	NFP
en-wikipedia-org-4107	1425	1	In	in	IN
en-wikipedia-org-4107	1425	2	animal	animal	NN
en-wikipedia-org-4107	1425	3	models	model	NNS
en-wikipedia-org-4107	1425	4	that	that	WDT
en-wikipedia-org-4107	1425	5	evaluate	evaluate	VBP
en-wikipedia-org-4107	1425	6	the	the	DT
en-wikipedia-org-4107	1425	7	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	1425	8	of	of	IN
en-wikipedia-org-4107	1425	9	AMPH	AMPH	NNP
en-wikipedia-org-4107	1425	10	and	and	CC
en-wikipedia-org-4107	1425	11	METH	METH	NNP
en-wikipedia-org-4107	1425	12	,	,	,
en-wikipedia-org-4107	1425	13	it	-PRON-	PRP
en-wikipedia-org-4107	1425	14	is	be	VBZ
en-wikipedia-org-4107	1425	15	quite	quite	RB
en-wikipedia-org-4107	1425	16	clear	clear	JJ
en-wikipedia-org-4107	1425	17	that	that	IN
en-wikipedia-org-4107	1425	18	hyperthermia	hyperthermia	NN
en-wikipedia-org-4107	1425	19	is	be	VBZ
en-wikipedia-org-4107	1425	20	one	one	CD
en-wikipedia-org-4107	1425	21	of	of	IN
en-wikipedia-org-4107	1425	22	the	the	DT
en-wikipedia-org-4107	1425	23	essential	essential	JJ
en-wikipedia-org-4107	1425	24	components	component	NNS
en-wikipedia-org-4107	1425	25	necessary	necessary	JJ
en-wikipedia-org-4107	1425	26	for	for	IN
en-wikipedia-org-4107	1425	27	the	the	DT
en-wikipedia-org-4107	1425	28	production	production	NN
en-wikipedia-org-4107	1425	29	of	of	IN
en-wikipedia-org-4107	1425	30	histological	histological	JJ
en-wikipedia-org-4107	1425	31	signs	sign	NNS
en-wikipedia-org-4107	1425	32	of	of	IN
en-wikipedia-org-4107	1425	33	dopamine	dopamine	NN
en-wikipedia-org-4107	1425	34	terminal	terminal	JJ
en-wikipedia-org-4107	1425	35	damage	damage	NN
en-wikipedia-org-4107	1425	36	and	and	CC
en-wikipedia-org-4107	1425	37	neurodegeneration	neurodegeneration	NN
en-wikipedia-org-4107	1425	38	in	in	IN
en-wikipedia-org-4107	1425	39	cortex	cortex	NNP
en-wikipedia-org-4107	1425	40	,	,	,
en-wikipedia-org-4107	1425	41	striatum	striatum	NN
en-wikipedia-org-4107	1425	42	,	,	,
en-wikipedia-org-4107	1425	43	thalamus	thalamus	NNP
en-wikipedia-org-4107	1425	44	and	and	CC
en-wikipedia-org-4107	1425	45	hippocampus	hippocampus	NNP
en-wikipedia-org-4107	1425	46	.	.	.
en-wikipedia-org-4107	1426	1	^	^	FW
en-wikipedia-org-4107	1426	2	"	"	``
en-wikipedia-org-4107	1426	3	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1426	4	"	"	''
en-wikipedia-org-4107	1426	5	.	.	.
en-wikipedia-org-4107	1427	1	United	United	NNP
en-wikipedia-org-4107	1427	2	States	States	NNP
en-wikipedia-org-4107	1427	3	National	National	NNP
en-wikipedia-org-4107	1427	4	Library	Library	NNP
en-wikipedia-org-4107	1427	5	of	of	IN
en-wikipedia-org-4107	1427	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	1427	7	 	  	_SP
en-wikipedia-org-4107	1427	8	–	–	:
en-wikipedia-org-4107	1427	9	Toxicology	Toxicology	NNP
en-wikipedia-org-4107	1427	10	Data	Data	NNP
en-wikipedia-org-4107	1427	11	Network	Network	NNP
en-wikipedia-org-4107	1427	12	.	.	.
en-wikipedia-org-4107	1428	1	Hazardous	Hazardous	NNP
en-wikipedia-org-4107	1428	2	Substances	Substances	NNP
en-wikipedia-org-4107	1428	3	Data	Data	NNP
en-wikipedia-org-4107	1428	4	Bank	Bank	NNP
en-wikipedia-org-4107	1428	5	.	.	.
en-wikipedia-org-4107	1429	1	Archived	archived	JJ
en-wikipedia-org-4107	1429	2	from	from	IN
en-wikipedia-org-4107	1429	3	the	the	DT
en-wikipedia-org-4107	1429	4	original	original	NN
en-wikipedia-org-4107	1429	5	on	on	IN
en-wikipedia-org-4107	1429	6	2	2	CD
en-wikipedia-org-4107	1429	7	October	October	NNP
en-wikipedia-org-4107	1429	8	2017	2017	CD
en-wikipedia-org-4107	1429	9	.	.	.
en-wikipedia-org-4107	1430	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1430	2	2	2	CD
en-wikipedia-org-4107	1430	3	October	October	NNP
en-wikipedia-org-4107	1430	4	2017	2017	CD
en-wikipedia-org-4107	1430	5	.	.	.
en-wikipedia-org-4107	1431	1	Direct	direct	JJ
en-wikipedia-org-4107	1431	2	toxic	toxic	JJ
en-wikipedia-org-4107	1431	3	damage	damage	NN
en-wikipedia-org-4107	1431	4	to	to	IN
en-wikipedia-org-4107	1431	5	vessels	vessel	NNS
en-wikipedia-org-4107	1431	6	seems	seem	VBZ
en-wikipedia-org-4107	1431	7	unlikely	unlikely	JJ
en-wikipedia-org-4107	1431	8	because	because	IN
en-wikipedia-org-4107	1431	9	of	of	IN
en-wikipedia-org-4107	1431	10	the	the	DT
en-wikipedia-org-4107	1431	11	dilution	dilution	NN
en-wikipedia-org-4107	1431	12	that	that	WDT
en-wikipedia-org-4107	1431	13	occurs	occur	VBZ
en-wikipedia-org-4107	1431	14	before	before	IN
en-wikipedia-org-4107	1431	15	the	the	DT
en-wikipedia-org-4107	1431	16	drug	drug	NN
en-wikipedia-org-4107	1431	17	reaches	reach	VBZ
en-wikipedia-org-4107	1431	18	the	the	DT
en-wikipedia-org-4107	1431	19	cerebral	cerebral	JJ
en-wikipedia-org-4107	1431	20	circulation	circulation	NN
en-wikipedia-org-4107	1431	21	.	.	.
en-wikipedia-org-4107	1432	1	^	^	NNP
en-wikipedia-org-4107	1432	2	Malenka	Malenka	NNP
en-wikipedia-org-4107	1432	3	RC	RC	NNP
en-wikipedia-org-4107	1432	4	,	,	,
en-wikipedia-org-4107	1432	5	Nestler	Nestler	NNP
en-wikipedia-org-4107	1432	6	EJ	EJ	NNP
en-wikipedia-org-4107	1432	7	,	,	,
en-wikipedia-org-4107	1432	8	Hyman	Hyman	NNP
en-wikipedia-org-4107	1432	9	SE	SE	NNP
en-wikipedia-org-4107	1432	10	(	(	-LRB-
en-wikipedia-org-4107	1432	11	2009	2009	CD
en-wikipedia-org-4107	1432	12	)	)	-RRB-
en-wikipedia-org-4107	1432	13	.	.	.
en-wikipedia-org-4107	1433	1	"	"	``
en-wikipedia-org-4107	1433	2	Chapter	chapter	NN
en-wikipedia-org-4107	1433	3	15	15	CD
en-wikipedia-org-4107	1433	4	:	:	:
en-wikipedia-org-4107	1433	5	Reinforcement	reinforcement	NN
en-wikipedia-org-4107	1433	6	and	and	CC
en-wikipedia-org-4107	1433	7	addictive	addictive	JJ
en-wikipedia-org-4107	1433	8	disorders	disorder	NNS
en-wikipedia-org-4107	1433	9	"	"	''
en-wikipedia-org-4107	1433	10	.	.	.
en-wikipedia-org-4107	1434	1	In	in	IN
en-wikipedia-org-4107	1434	2	Sydor	Sydor	NNP
en-wikipedia-org-4107	1434	3	A	A	NNP
en-wikipedia-org-4107	1434	4	,	,	,
en-wikipedia-org-4107	1434	5	Brown	Brown	NNP
en-wikipedia-org-4107	1434	6	RY	RY	NNP
en-wikipedia-org-4107	1434	7	(	(	-LRB-
en-wikipedia-org-4107	1434	8	eds	eds	NNP
en-wikipedia-org-4107	1434	9	.	.	.
en-wikipedia-org-4107	1434	10	)	)	-RRB-
en-wikipedia-org-4107	1434	11	.	.	.
en-wikipedia-org-4107	1435	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	1435	2	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-4107	1435	3	:	:	:
en-wikipedia-org-4107	1435	4	A	A	NNP
en-wikipedia-org-4107	1435	5	Foundation	Foundation	NNP
en-wikipedia-org-4107	1435	6	for	for	IN
en-wikipedia-org-4107	1435	7	Clinical	Clinical	NNP
en-wikipedia-org-4107	1435	8	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1435	9	(	(	-LRB-
en-wikipedia-org-4107	1435	10	2nd	2nd	NNP
en-wikipedia-org-4107	1435	11	ed	ed	NNP
en-wikipedia-org-4107	1435	12	.	.	.
en-wikipedia-org-4107	1435	13	)	)	-RRB-
en-wikipedia-org-4107	1435	14	.	.	.
en-wikipedia-org-4107	1436	1	New	New	NNP
en-wikipedia-org-4107	1436	2	York	York	NNP
en-wikipedia-org-4107	1436	3	,	,	,
en-wikipedia-org-4107	1436	4	USA	USA	NNP
en-wikipedia-org-4107	1436	5	:	:	:
en-wikipedia-org-4107	1436	6	McGraw	McGraw	NNP
en-wikipedia-org-4107	1436	7	-	-	HYPH
en-wikipedia-org-4107	1436	8	Hill	Hill	NNP
en-wikipedia-org-4107	1436	9	Medical	Medical	NNP
en-wikipedia-org-4107	1436	10	.	.	.
en-wikipedia-org-4107	1437	1	p.	p.	NN
en-wikipedia-org-4107	1437	2	 	  	_SP
en-wikipedia-org-4107	1437	3	370	370	CD
en-wikipedia-org-4107	1437	4	.	.	.
en-wikipedia-org-4107	1438	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	1438	2	 	  	_SP
en-wikipedia-org-4107	1438	3	9780071481274	9780071481274	CD
en-wikipedia-org-4107	1438	4	.	.	.
en-wikipedia-org-4107	1439	1	Unlike	unlike	IN
en-wikipedia-org-4107	1439	2	cocaine	cocaine	NN
en-wikipedia-org-4107	1439	3	and	and	CC
en-wikipedia-org-4107	1439	4	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1439	5	,	,	,
en-wikipedia-org-4107	1439	6	methamphetamine	methamphetamine	NNP
en-wikipedia-org-4107	1439	7	is	be	VBZ
en-wikipedia-org-4107	1439	8	directly	directly	RB
en-wikipedia-org-4107	1439	9	toxic	toxic	JJ
en-wikipedia-org-4107	1439	10	to	to	IN
en-wikipedia-org-4107	1439	11	midbrain	midbrain	VB
en-wikipedia-org-4107	1439	12	dopamine	dopamine	NN
en-wikipedia-org-4107	1439	13	neurons	neuron	NNS
en-wikipedia-org-4107	1439	14	.	.	.
en-wikipedia-org-4107	1440	1	^	^	NNP
en-wikipedia-org-4107	1440	2	Sulzer	Sulzer	NNP
en-wikipedia-org-4107	1440	3	D	D	NNP
en-wikipedia-org-4107	1440	4	,	,	,
en-wikipedia-org-4107	1440	5	Zecca	Zecca	NNP
en-wikipedia-org-4107	1440	6	L	L	NNP
en-wikipedia-org-4107	1440	7	(	(	-LRB-
en-wikipedia-org-4107	1440	8	February	February	NNP
en-wikipedia-org-4107	1440	9	2000	2000	CD
en-wikipedia-org-4107	1440	10	)	)	-RRB-
en-wikipedia-org-4107	1440	11	.	.	.
en-wikipedia-org-4107	1441	1	"	"	``
en-wikipedia-org-4107	1441	2	Intraneuronal	intraneuronal	JJ
en-wikipedia-org-4107	1441	3	dopamine	dopamine	NN
en-wikipedia-org-4107	1441	4	-	-	HYPH
en-wikipedia-org-4107	1441	5	quinone	quinone	NN
en-wikipedia-org-4107	1441	6	synthesis	synthesis	NN
en-wikipedia-org-4107	1441	7	:	:	:
en-wikipedia-org-4107	1441	8	a	a	DT
en-wikipedia-org-4107	1441	9	review	review	NN
en-wikipedia-org-4107	1441	10	"	"	''
en-wikipedia-org-4107	1441	11	.	.	.
en-wikipedia-org-4107	1442	1	Neurotoxicity	Neurotoxicity	NNP
en-wikipedia-org-4107	1442	2	Research	Research	NNP
en-wikipedia-org-4107	1442	3	.	.	.
en-wikipedia-org-4107	1443	1	1	1	CD
en-wikipedia-org-4107	1443	2	(	(	-LRB-
en-wikipedia-org-4107	1443	3	3	3	CD
en-wikipedia-org-4107	1443	4	)	)	-RRB-
en-wikipedia-org-4107	1443	5	:	:	:
en-wikipedia-org-4107	1443	6	181–195	181–195	CD
en-wikipedia-org-4107	1443	7	.	.	.
en-wikipedia-org-4107	1444	1	doi:10.1007	doi:10.1007	NNP
en-wikipedia-org-4107	1444	2	/	/	SYM
en-wikipedia-org-4107	1444	3	BF03033289	bf03033289	UH
en-wikipedia-org-4107	1444	4	.	.	.
en-wikipedia-org-4107	1445	1	PMID	PMID	NNP
en-wikipedia-org-4107	1445	2	 	  	_SP
en-wikipedia-org-4107	1445	3	12835101	12835101	CD
en-wikipedia-org-4107	1445	4	.	.	.
en-wikipedia-org-4107	1446	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1446	2	 	  	_SP
en-wikipedia-org-4107	1446	3	21892355	21892355	CD
en-wikipedia-org-4107	1446	4	.	.	.
en-wikipedia-org-4107	1447	1	^	^	NFP
en-wikipedia-org-4107	1447	2	Miyazaki	Miyazaki	NNP
en-wikipedia-org-4107	1447	3	I	I	NNP
en-wikipedia-org-4107	1447	4	,	,	,
en-wikipedia-org-4107	1447	5	Asanuma	Asanuma	NNP
en-wikipedia-org-4107	1447	6	M	M	NNP
en-wikipedia-org-4107	1447	7	(	(	-LRB-
en-wikipedia-org-4107	1447	8	June	June	NNP
en-wikipedia-org-4107	1447	9	2008	2008	CD
en-wikipedia-org-4107	1447	10	)	)	-RRB-
en-wikipedia-org-4107	1447	11	.	.	.
en-wikipedia-org-4107	1448	1	"	"	``
en-wikipedia-org-4107	1448	2	Dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	1448	3	neuron	neuron	NN
en-wikipedia-org-4107	1448	4	-	-	HYPH
en-wikipedia-org-4107	1448	5	specific	specific	JJ
en-wikipedia-org-4107	1448	6	oxidative	oxidative	JJ
en-wikipedia-org-4107	1448	7	stress	stress	NN
en-wikipedia-org-4107	1448	8	caused	cause	VBN
en-wikipedia-org-4107	1448	9	by	by	IN
en-wikipedia-org-4107	1448	10	dopamine	dopamine	NN
en-wikipedia-org-4107	1448	11	itself	-PRON-	PRP
en-wikipedia-org-4107	1448	12	"	"	''
en-wikipedia-org-4107	1448	13	(	(	-LRB-
en-wikipedia-org-4107	1448	14	PDF	PDF	NNP
en-wikipedia-org-4107	1448	15	)	)	-RRB-
en-wikipedia-org-4107	1448	16	.	.	.
en-wikipedia-org-4107	1449	1	Acta	Acta	NNP
en-wikipedia-org-4107	1449	2	Medica	Medica	NNP
en-wikipedia-org-4107	1449	3	Okayama	Okayama	NNP
en-wikipedia-org-4107	1449	4	.	.	.
en-wikipedia-org-4107	1450	1	62	62	CD
en-wikipedia-org-4107	1450	2	(	(	-LRB-
en-wikipedia-org-4107	1450	3	3	3	CD
en-wikipedia-org-4107	1450	4	)	)	-RRB-
en-wikipedia-org-4107	1450	5	:	:	:
en-wikipedia-org-4107	1450	6	141–150	141–150	CD
en-wikipedia-org-4107	1450	7	.	.	.
en-wikipedia-org-4107	1451	1	doi:10.18926	doi:10.18926	LS
en-wikipedia-org-4107	1451	2	/	/	SYM
en-wikipedia-org-4107	1451	3	AMO/30942	amo/30942	XX
en-wikipedia-org-4107	1451	4	.	.	.
en-wikipedia-org-4107	1452	1	PMID	PMID	NNP
en-wikipedia-org-4107	1452	2	 	  	_SP
en-wikipedia-org-4107	1452	3	18596830	18596830	CD
en-wikipedia-org-4107	1452	4	.	.	.
en-wikipedia-org-4107	1453	1	^	^	NNP
en-wikipedia-org-4107	1453	2	Hofmann	Hofmann	NNP
en-wikipedia-org-4107	1453	3	FG	FG	NNP
en-wikipedia-org-4107	1453	4	(	(	-LRB-
en-wikipedia-org-4107	1453	5	1983	1983	CD
en-wikipedia-org-4107	1453	6	)	)	-RRB-
en-wikipedia-org-4107	1453	7	.	.	.
en-wikipedia-org-4107	1454	1	A	a	DT
en-wikipedia-org-4107	1454	2	Handbook	Handbook	NNP
en-wikipedia-org-4107	1454	3	on	on	IN
en-wikipedia-org-4107	1454	4	Drug	Drug	NNP
en-wikipedia-org-4107	1454	5	and	and	CC
en-wikipedia-org-4107	1454	6	Alcohol	Alcohol	NNP
en-wikipedia-org-4107	1454	7	Abuse	Abuse	NNP
en-wikipedia-org-4107	1454	8	:	:	:
en-wikipedia-org-4107	1454	9	The	the	DT
en-wikipedia-org-4107	1454	10	Biomedical	Biomedical	NNP
en-wikipedia-org-4107	1454	11	Aspects	Aspects	NNPS
en-wikipedia-org-4107	1454	12	(	(	-LRB-
en-wikipedia-org-4107	1454	13	2nd	2nd	NNP
en-wikipedia-org-4107	1454	14	ed	ed	NNP
en-wikipedia-org-4107	1454	15	.	.	.
en-wikipedia-org-4107	1454	16	)	)	-RRB-
en-wikipedia-org-4107	1454	17	.	.	.
en-wikipedia-org-4107	1455	1	New	New	NNP
en-wikipedia-org-4107	1455	2	York	York	NNP
en-wikipedia-org-4107	1455	3	,	,	,
en-wikipedia-org-4107	1455	4	USA	USA	NNP
en-wikipedia-org-4107	1455	5	:	:	:
en-wikipedia-org-4107	1455	6	Oxford	Oxford	NNP
en-wikipedia-org-4107	1455	7	University	University	NNP
en-wikipedia-org-4107	1455	8	Press	Press	NNP
en-wikipedia-org-4107	1455	9	.	.	.
en-wikipedia-org-4107	1456	1	p.	p.	NN
en-wikipedia-org-4107	1456	2	 	  	_SP
en-wikipedia-org-4107	1456	3	329	329	CD
en-wikipedia-org-4107	1456	4	.	.	.
en-wikipedia-org-4107	1457	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	1457	2	 	  	_SP
en-wikipedia-org-4107	1457	3	9780195030570	9780195030570	CD
en-wikipedia-org-4107	1457	4	.	.	.
en-wikipedia-org-4107	1458	1	^	^	NNP
en-wikipedia-org-4107	1458	2	Hasenhuetl	Hasenhuetl	NNP
en-wikipedia-org-4107	1458	3	PS	PS	NNP
en-wikipedia-org-4107	1458	4	,	,	,
en-wikipedia-org-4107	1458	5	Bhat	Bhat	NNP
en-wikipedia-org-4107	1458	6	S	S	NNP
en-wikipedia-org-4107	1458	7	,	,	,
en-wikipedia-org-4107	1458	8	Freissmuth	Freissmuth	NNP
en-wikipedia-org-4107	1458	9	M	M	NNP
en-wikipedia-org-4107	1458	10	,	,	,
en-wikipedia-org-4107	1458	11	Sandtner	Sandtner	NNP
en-wikipedia-org-4107	1458	12	W	W	NNP
en-wikipedia-org-4107	1458	13	(	(	-LRB-
en-wikipedia-org-4107	1458	14	March	March	NNP
en-wikipedia-org-4107	1458	15	2019	2019	CD
en-wikipedia-org-4107	1458	16	)	)	-RRB-
en-wikipedia-org-4107	1458	17	.	.	.
en-wikipedia-org-4107	1459	1	"	"	``
en-wikipedia-org-4107	1459	2	Functional	Functional	NNP
en-wikipedia-org-4107	1459	3	Selectivity	Selectivity	NNP
en-wikipedia-org-4107	1459	4	and	and	CC
en-wikipedia-org-4107	1459	5	Partial	Partial	NNP
en-wikipedia-org-4107	1459	6	Efficacy	Efficacy	NNP
en-wikipedia-org-4107	1459	7	at	at	IN
en-wikipedia-org-4107	1459	8	the	the	DT
en-wikipedia-org-4107	1459	9	Monoamine	Monoamine	NNP
en-wikipedia-org-4107	1459	10	Transporters	Transporters	NNP
en-wikipedia-org-4107	1459	11	:	:	:
en-wikipedia-org-4107	1459	12	A	a	DT
en-wikipedia-org-4107	1459	13	Unified	Unified	NNP
en-wikipedia-org-4107	1459	14	Model	Model	NNP
en-wikipedia-org-4107	1459	15	of	of	IN
en-wikipedia-org-4107	1459	16	Allosteric	Allosteric	NNP
en-wikipedia-org-4107	1459	17	Modulation	Modulation	NNP
en-wikipedia-org-4107	1459	18	and	and	CC
en-wikipedia-org-4107	1459	19	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1459	20	-	-	HYPH
en-wikipedia-org-4107	1459	21	Induced	Induced	NNP
en-wikipedia-org-4107	1459	22	Substrate	Substrate	NNP
en-wikipedia-org-4107	1459	23	Release	Release	NNP
en-wikipedia-org-4107	1459	24	"	"	''
en-wikipedia-org-4107	1459	25	.	.	.
en-wikipedia-org-4107	1460	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	1460	2	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1460	3	.	.	.
en-wikipedia-org-4107	1461	1	95	95	CD
en-wikipedia-org-4107	1461	2	(	(	-LRB-
en-wikipedia-org-4107	1461	3	3	3	CD
en-wikipedia-org-4107	1461	4	)	)	-RRB-
en-wikipedia-org-4107	1461	5	:	:	:
en-wikipedia-org-4107	1461	6	303–312	303–312	CD
en-wikipedia-org-4107	1461	7	.	.	.
en-wikipedia-org-4107	1462	1	doi:10.1124	doi:10.1124	NNP
en-wikipedia-org-4107	1462	2	/	/	SYM
en-wikipedia-org-4107	1462	3	mol.118.114793	mol.118.114793	NN
en-wikipedia-org-4107	1462	4	.	.	.
en-wikipedia-org-4107	1463	1	PMID	PMID	NNP
en-wikipedia-org-4107	1463	2	 	  	_SP
en-wikipedia-org-4107	1463	3	30567955	30567955	CD
en-wikipedia-org-4107	1463	4	.	.	.
en-wikipedia-org-4107	1464	1	S2CID	S2CID	NNP
en-wikipedia-org-4107	1464	2	 	  	_SP
en-wikipedia-org-4107	1464	3	58557130	58557130	CD
en-wikipedia-org-4107	1464	4	.	.	.
en-wikipedia-org-4107	1465	1	Although	although	IN
en-wikipedia-org-4107	1465	2	the	the	DT
en-wikipedia-org-4107	1465	3	monoamine	monoamine	NN
en-wikipedia-org-4107	1465	4	transport	transport	NN
en-wikipedia-org-4107	1465	5	cycle	cycle	NN
en-wikipedia-org-4107	1465	6	has	have	VBZ
en-wikipedia-org-4107	1465	7	been	be	VBN
en-wikipedia-org-4107	1465	8	resolved	resolve	VBN
en-wikipedia-org-4107	1465	9	in	in	IN
en-wikipedia-org-4107	1465	10	considerable	considerable	JJ
en-wikipedia-org-4107	1465	11	detail	detail	NN
en-wikipedia-org-4107	1465	12	,	,	,
en-wikipedia-org-4107	1465	13	kinetic	kinetic	JJ
en-wikipedia-org-4107	1465	14	knowledge	knowledge	NN
en-wikipedia-org-4107	1465	15	on	on	IN
en-wikipedia-org-4107	1465	16	the	the	DT
en-wikipedia-org-4107	1465	17	molecular	molecular	JJ
en-wikipedia-org-4107	1465	18	actions	action	NNS
en-wikipedia-org-4107	1465	19	of	of	IN
en-wikipedia-org-4107	1465	20	synthetic	synthetic	JJ
en-wikipedia-org-4107	1465	21	allosteric	allosteric	JJ
en-wikipedia-org-4107	1465	22	modulators	modulator	NNS
en-wikipedia-org-4107	1465	23	is	be	VBZ
en-wikipedia-org-4107	1465	24	still	still	RB
en-wikipedia-org-4107	1465	25	scarce	scarce	JJ
en-wikipedia-org-4107	1465	26	.	.	.
en-wikipedia-org-4107	1466	1	Fortunately	fortunately	RB
en-wikipedia-org-4107	1466	2	,	,	,
en-wikipedia-org-4107	1466	3	the	the	DT
en-wikipedia-org-4107	1466	4	DAT	DAT	NNP
en-wikipedia-org-4107	1466	5	catalytic	catalytic	JJ
en-wikipedia-org-4107	1466	6	cycle	cycle	NN
en-wikipedia-org-4107	1466	7	is	be	VBZ
en-wikipedia-org-4107	1466	8	allosterically	allosterically	RB
en-wikipedia-org-4107	1466	9	modulated	modulate	VBN
en-wikipedia-org-4107	1466	10	by	by	IN
en-wikipedia-org-4107	1466	11	an	an	DT
en-wikipedia-org-4107	1466	12	endogenous	endogenous	JJ
en-wikipedia-org-4107	1466	13	ligand	ligand	NN
en-wikipedia-org-4107	1466	14	(	(	-LRB-
en-wikipedia-org-4107	1466	15	namely	namely	RB
en-wikipedia-org-4107	1466	16	,	,	,
en-wikipedia-org-4107	1466	17	Zn2	Zn2	NNP
en-wikipedia-org-4107	1466	18	+	+	SYM
en-wikipedia-org-4107	1466	19	;	;	:
en-wikipedia-org-4107	1466	20	Norregaard	Norregaard	NNP
en-wikipedia-org-4107	1466	21	et	et	NNP
en-wikipedia-org-4107	1466	22	al	al	NNP
en-wikipedia-org-4107	1466	23	.	.	NNP
en-wikipedia-org-4107	1466	24	,	,	,
en-wikipedia-org-4107	1466	25	1998	1998	CD
en-wikipedia-org-4107	1466	26	)	)	-RRB-
en-wikipedia-org-4107	1466	27	.	.	.
en-wikipedia-org-4107	1467	1	It	-PRON-	PRP
en-wikipedia-org-4107	1467	2	is	be	VBZ
en-wikipedia-org-4107	1467	3	worth	worth	JJ
en-wikipedia-org-4107	1467	4	consulting	consult	VBG
en-wikipedia-org-4107	1467	5	Zn2	zn2	XX
en-wikipedia-org-4107	1467	6	+	+	SYM
en-wikipedia-org-4107	1467	7	as	as	IN
en-wikipedia-org-4107	1467	8	an	an	DT
en-wikipedia-org-4107	1467	9	instructive	instructive	JJ
en-wikipedia-org-4107	1467	10	example	example	NN
en-wikipedia-org-4107	1467	11	,	,	,
en-wikipedia-org-4107	1467	12	because	because	IN
en-wikipedia-org-4107	1467	13	its	-PRON-	PRP$
en-wikipedia-org-4107	1467	14	action	action	NN
en-wikipedia-org-4107	1467	15	on	on	IN
en-wikipedia-org-4107	1467	16	the	the	DT
en-wikipedia-org-4107	1467	17	DAT	DAT	NNP
en-wikipedia-org-4107	1467	18	catalytic	catalytic	JJ
en-wikipedia-org-4107	1467	19	cycle	cycle	NN
en-wikipedia-org-4107	1467	20	has	have	VBZ
en-wikipedia-org-4107	1467	21	been	be	VBN
en-wikipedia-org-4107	1467	22	deciphered	decipher	VBN
en-wikipedia-org-4107	1467	23	to	to	IN
en-wikipedia-org-4107	1467	24	a	a	DT
en-wikipedia-org-4107	1467	25	large	large	JJ
en-wikipedia-org-4107	1467	26	extent	extent	NN
en-wikipedia-org-4107	1467	27	 	  	_SP
en-wikipedia-org-4107	1467	28	...	...	NFP
en-wikipedia-org-4107	1467	29	Zn+	zn+	XX
en-wikipedia-org-4107	1467	30	binding	binding	NN
en-wikipedia-org-4107	1467	31	stabilizes	stabilize	VBZ
en-wikipedia-org-4107	1467	32	the	the	DT
en-wikipedia-org-4107	1467	33	outward	outward	RB
en-wikipedia-org-4107	1467	34	-	-	HYPH
en-wikipedia-org-4107	1467	35	facing	face	VBG
en-wikipedia-org-4107	1467	36	conformation	conformation	NN
en-wikipedia-org-4107	1467	37	of	of	IN
en-wikipedia-org-4107	1467	38	DAT	DAT	NNP
en-wikipedia-org-4107	1467	39	 	  	_SP
en-wikipedia-org-4107	1467	40	...	...	:
en-wikipedia-org-4107	1468	1	This	this	DT
en-wikipedia-org-4107	1468	2	potentiates	potentiate	VBZ
en-wikipedia-org-4107	1468	3	both	both	DT
en-wikipedia-org-4107	1468	4	the	the	DT
en-wikipedia-org-4107	1468	5	forward	forward	JJ
en-wikipedia-org-4107	1468	6	-	-	HYPH
en-wikipedia-org-4107	1468	7	transport	transport	NN
en-wikipedia-org-4107	1468	8	mode	mode	NN
en-wikipedia-org-4107	1468	9	(	(	-LRB-
en-wikipedia-org-4107	1468	10	i.e.	i.e.	FW
en-wikipedia-org-4107	1468	11	,	,	,
en-wikipedia-org-4107	1468	12	DA	DA	NNP
en-wikipedia-org-4107	1468	13	uptake	uptake	NN
en-wikipedia-org-4107	1468	14	;	;	:
en-wikipedia-org-4107	1468	15	Li	Li	NNP
en-wikipedia-org-4107	1468	16	et	et	NNP
en-wikipedia-org-4107	1468	17	al	al	NNP
en-wikipedia-org-4107	1468	18	.	.	NNP
en-wikipedia-org-4107	1468	19	,	,	,
en-wikipedia-org-4107	1468	20	2015	2015	CD
en-wikipedia-org-4107	1468	21	)	)	-RRB-
en-wikipedia-org-4107	1468	22	and	and	CC
en-wikipedia-org-4107	1468	23	the	the	DT
en-wikipedia-org-4107	1468	24	substrate	substrate	JJ
en-wikipedia-org-4107	1468	25	-	-	HYPH
en-wikipedia-org-4107	1468	26	exchange	exchange	NN
en-wikipedia-org-4107	1468	27	mode	mode	NN
en-wikipedia-org-4107	1468	28	(	(	-LRB-
en-wikipedia-org-4107	1468	29	i.e.	i.e.	FW
en-wikipedia-org-4107	1468	30	,	,	,
en-wikipedia-org-4107	1468	31	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1468	32	-	-	HYPH
en-wikipedia-org-4107	1468	33	induced	induce	VBN
en-wikipedia-org-4107	1468	34	DA	DA	NNP
en-wikipedia-org-4107	1468	35	release	release	NN
en-wikipedia-org-4107	1468	36	;	;	:
en-wikipedia-org-4107	1468	37	Meinild	Meinild	NNP
en-wikipedia-org-4107	1468	38	et	et	FW
en-wikipedia-org-4107	1468	39	al	al	NNP
en-wikipedia-org-4107	1468	40	.	.	NNP
en-wikipedia-org-4107	1468	41	,	,	,
en-wikipedia-org-4107	1468	42	2004	2004	CD
en-wikipedia-org-4107	1468	43	;	;	:
en-wikipedia-org-4107	1468	44	Li	Li	NNP
en-wikipedia-org-4107	1468	45	et	et	NNP
en-wikipedia-org-4107	1468	46	al	al	NNP
en-wikipedia-org-4107	1468	47	.	.	NNP
en-wikipedia-org-4107	1468	48	,	,	,
en-wikipedia-org-4107	1468	49	2015	2015	CD
en-wikipedia-org-4107	1468	50	)	)	-RRB-
en-wikipedia-org-4107	1468	51	.	.	.
en-wikipedia-org-4107	1469	1	Importantly	importantly	RB
en-wikipedia-org-4107	1469	2	,	,	,
en-wikipedia-org-4107	1469	3	the	the	DT
en-wikipedia-org-4107	1469	4	potentiating	potentiate	VBG
en-wikipedia-org-4107	1469	5	effect	effect	NN
en-wikipedia-org-4107	1469	6	on	on	IN
en-wikipedia-org-4107	1469	7	substrate	substrate	NN
en-wikipedia-org-4107	1469	8	uptake	uptake	NN
en-wikipedia-org-4107	1469	9	is	be	VBZ
en-wikipedia-org-4107	1469	10	only	only	RB
en-wikipedia-org-4107	1469	11	evident	evident	JJ
en-wikipedia-org-4107	1469	12	when	when	WRB
en-wikipedia-org-4107	1469	13	internal	internal	JJ
en-wikipedia-org-4107	1469	14	Na+	na+	NN
en-wikipedia-org-4107	1469	15	concentrations	concentration	NNS
en-wikipedia-org-4107	1469	16	are	be	VBP
en-wikipedia-org-4107	1469	17	low	low	JJ
en-wikipedia-org-4107	1469	18	 	  	_SP
en-wikipedia-org-4107	1469	19	...	...	:
en-wikipedia-org-4107	1470	1	If	if	IN
en-wikipedia-org-4107	1470	2	internal	internal	JJ
en-wikipedia-org-4107	1470	3	Na+	na+	CC
en-wikipedia-org-4107	1470	4	concentrations	concentration	NNS
en-wikipedia-org-4107	1470	5	rise	rise	VBP
en-wikipedia-org-4107	1470	6	during	during	IN
en-wikipedia-org-4107	1470	7	the	the	DT
en-wikipedia-org-4107	1470	8	experiment	experiment	NN
en-wikipedia-org-4107	1470	9	,	,	,
en-wikipedia-org-4107	1470	10	the	the	DT
en-wikipedia-org-4107	1470	11	substrate	substrate	JJ
en-wikipedia-org-4107	1470	12	-	-	HYPH
en-wikipedia-org-4107	1470	13	exchange	exchange	NN
en-wikipedia-org-4107	1470	14	mode	mode	NN
en-wikipedia-org-4107	1470	15	dominates	dominate	NNS
en-wikipedia-org-4107	1470	16	and	and	CC
en-wikipedia-org-4107	1470	17	the	the	DT
en-wikipedia-org-4107	1470	18	net	net	JJ
en-wikipedia-org-4107	1470	19	effect	effect	NN
en-wikipedia-org-4107	1470	20	of	of	IN
en-wikipedia-org-4107	1470	21	Zn2	Zn2	NNP
en-wikipedia-org-4107	1470	22	+	+	SYM
en-wikipedia-org-4107	1470	23	on	on	IN
en-wikipedia-org-4107	1470	24	uptake	uptake	JJ
en-wikipedia-org-4107	1470	25	is	be	VBZ
en-wikipedia-org-4107	1470	26	inhibitory	inhibitory	JJ
en-wikipedia-org-4107	1470	27	.	.	.
en-wikipedia-org-4107	1471	1	Conversely	conversely	RB
en-wikipedia-org-4107	1471	2	,	,	,
en-wikipedia-org-4107	1471	3	Zn2	Zn2	NNP
en-wikipedia-org-4107	1471	4	+	+	CC
en-wikipedia-org-4107	1471	5	accelerates	accelerate	VBZ
en-wikipedia-org-4107	1471	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1471	7	-	-	HYPH
en-wikipedia-org-4107	1471	8	induced	induce	VBN
en-wikipedia-org-4107	1471	9	substrate	substrate	NN
en-wikipedia-org-4107	1471	10	release	release	NN
en-wikipedia-org-4107	1471	11	via	via	IN
en-wikipedia-org-4107	1471	12	DAT	DAT	NNP
en-wikipedia-org-4107	1471	13	.	.	.
en-wikipedia-org-4107	1472	1	...	...	NFP
en-wikipedia-org-4107	1472	2	t	t	NNP
en-wikipedia-org-4107	1472	3	is	be	VBZ
en-wikipedia-org-4107	1472	4	important	important	JJ
en-wikipedia-org-4107	1472	5	to	to	TO
en-wikipedia-org-4107	1472	6	emphasize	emphasize	VB
en-wikipedia-org-4107	1472	7	that	that	IN
en-wikipedia-org-4107	1472	8	Zn2	Zn2	NNP
en-wikipedia-org-4107	1472	9	+	+	SYM
en-wikipedia-org-4107	1472	10	has	have	VBZ
en-wikipedia-org-4107	1472	11	been	be	VBN
en-wikipedia-org-4107	1472	12	shown	show	VBN
en-wikipedia-org-4107	1472	13	to	to	TO
en-wikipedia-org-4107	1472	14	reduce	reduce	VB
en-wikipedia-org-4107	1472	15	dopamine	dopamine	NN
en-wikipedia-org-4107	1472	16	uptake	uptake	NN
en-wikipedia-org-4107	1472	17	under	under	IN
en-wikipedia-org-4107	1472	18	conditions	condition	NNS
en-wikipedia-org-4107	1472	19	that	that	WDT
en-wikipedia-org-4107	1472	20	favor	favor	VBP
en-wikipedia-org-4107	1472	21	intracellular	intracellular	JJ
en-wikipedia-org-4107	1472	22	Na+	na+	CC
en-wikipedia-org-4107	1472	23	accumulation	accumulation	NN
en-wikipedia-org-4107	1472	24	Fig	Fig	NNP
en-wikipedia-org-4107	1472	25	.	.	.
en-wikipedia-org-4107	1473	1	3	3	LS
en-wikipedia-org-4107	1473	2	.	.	.
en-wikipedia-org-4107	1474	1	Functional	functional	JJ
en-wikipedia-org-4107	1474	2	selectivity	selectivity	NN
en-wikipedia-org-4107	1474	3	by	by	IN
en-wikipedia-org-4107	1474	4	conformational	conformational	JJ
en-wikipedia-org-4107	1474	5	selection	selection	NN
en-wikipedia-org-4107	1474	6	.	.	.
en-wikipedia-org-4107	1475	1	^	^	NNP
en-wikipedia-org-4107	1475	2	Krause	Krause	NNP
en-wikipedia-org-4107	1475	3	J	J	NNP
en-wikipedia-org-4107	1475	4	(	(	-LRB-
en-wikipedia-org-4107	1475	5	April	April	NNP
en-wikipedia-org-4107	1475	6	2008	2008	CD
en-wikipedia-org-4107	1475	7	)	)	-RRB-
en-wikipedia-org-4107	1475	8	.	.	.
en-wikipedia-org-4107	1476	1	"	"	``
en-wikipedia-org-4107	1476	2	SPECT	SPECT	NNP
en-wikipedia-org-4107	1476	3	and	and	CC
en-wikipedia-org-4107	1476	4	PET	PET	NNP
en-wikipedia-org-4107	1476	5	of	of	IN
en-wikipedia-org-4107	1476	6	the	the	DT
en-wikipedia-org-4107	1476	7	dopamine	dopamine	NN
en-wikipedia-org-4107	1476	8	transporter	transporter	NN
en-wikipedia-org-4107	1476	9	in	in	IN
en-wikipedia-org-4107	1476	10	attention	attention	NN
en-wikipedia-org-4107	1476	11	-	-	HYPH
en-wikipedia-org-4107	1476	12	deficit	deficit	NN
en-wikipedia-org-4107	1476	13	/	/	SYM
en-wikipedia-org-4107	1476	14	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	1476	15	disorder	disorder	NN
en-wikipedia-org-4107	1476	16	"	"	''
en-wikipedia-org-4107	1476	17	.	.	.
en-wikipedia-org-4107	1477	1	Expert	expert	NN
en-wikipedia-org-4107	1477	2	Review	Review	NNP
en-wikipedia-org-4107	1477	3	of	of	IN
en-wikipedia-org-4107	1477	4	Neurotherapeutics	Neurotherapeutics	NNP
en-wikipedia-org-4107	1477	5	.	.	.
en-wikipedia-org-4107	1478	1	8	8	CD
en-wikipedia-org-4107	1478	2	(	(	-LRB-
en-wikipedia-org-4107	1478	3	4	4	CD
en-wikipedia-org-4107	1478	4	)	)	-RRB-
en-wikipedia-org-4107	1478	5	:	:	:
en-wikipedia-org-4107	1478	6	611–625	611–625	CD
en-wikipedia-org-4107	1478	7	.	.	.
en-wikipedia-org-4107	1479	1	doi:10.1586/14737175.8.4.611	doi:10.1586/14737175.8.4.611	NN
en-wikipedia-org-4107	1479	2	.	.	.
en-wikipedia-org-4107	1480	1	PMID	PMID	NNP
en-wikipedia-org-4107	1480	2	 	  	_SP
en-wikipedia-org-4107	1480	3	18416663	18416663	CD
en-wikipedia-org-4107	1480	4	.	.	.
en-wikipedia-org-4107	1481	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1481	2	 	  	_SP
en-wikipedia-org-4107	1481	3	24589993	24589993	CD
en-wikipedia-org-4107	1481	4	.	.	.
en-wikipedia-org-4107	1482	1	Zinc	zinc	NN
en-wikipedia-org-4107	1482	2	binds	bind	NNS
en-wikipedia-org-4107	1482	3	at	at	IN
en-wikipedia-org-4107	1482	4	 	  	_SP
en-wikipedia-org-4107	1482	5	...	...	:
en-wikipedia-org-4107	1482	6	extracellular	extracellular	NNP
en-wikipedia-org-4107	1482	7	sites	site	NNS
en-wikipedia-org-4107	1482	8	of	of	IN
en-wikipedia-org-4107	1482	9	the	the	DT
en-wikipedia-org-4107	1482	10	DAT	DAT	NNP
en-wikipedia-org-4107	1482	11	[	[	-LRB-
en-wikipedia-org-4107	1482	12	103	103	CD
en-wikipedia-org-4107	1482	13	]	]	-RRB-
en-wikipedia-org-4107	1482	14	,	,	,
en-wikipedia-org-4107	1482	15	serving	serve	VBG
en-wikipedia-org-4107	1482	16	as	as	IN
en-wikipedia-org-4107	1482	17	a	a	DT
en-wikipedia-org-4107	1482	18	DAT	DAT	NNP
en-wikipedia-org-4107	1482	19	inhibitor	inhibitor	NN
en-wikipedia-org-4107	1482	20	.	.	.
en-wikipedia-org-4107	1483	1	In	in	IN
en-wikipedia-org-4107	1483	2	this	this	DT
en-wikipedia-org-4107	1483	3	context	context	NN
en-wikipedia-org-4107	1483	4	,	,	,
en-wikipedia-org-4107	1483	5	controlled	control	VBN
en-wikipedia-org-4107	1483	6	double	double	JJ
en-wikipedia-org-4107	1483	7	-	-	HYPH
en-wikipedia-org-4107	1483	8	blind	blind	JJ
en-wikipedia-org-4107	1483	9	studies	study	NNS
en-wikipedia-org-4107	1483	10	in	in	IN
en-wikipedia-org-4107	1483	11	children	child	NNS
en-wikipedia-org-4107	1483	12	are	be	VBP
en-wikipedia-org-4107	1483	13	of	of	IN
en-wikipedia-org-4107	1483	14	interest	interest	NN
en-wikipedia-org-4107	1483	15	,	,	,
en-wikipedia-org-4107	1483	16	which	which	WDT
en-wikipedia-org-4107	1483	17	showed	show	VBD
en-wikipedia-org-4107	1483	18	positive	positive	JJ
en-wikipedia-org-4107	1483	19	effects	effect	NNS
en-wikipedia-org-4107	1483	20	of	of	IN
en-wikipedia-org-4107	1483	21	zinc	zinc	NN
en-wikipedia-org-4107	1483	22	[	[	-LRB-
en-wikipedia-org-4107	1483	23	supplementation	supplementation	NN
en-wikipedia-org-4107	1483	24	]	]	-RRB-
en-wikipedia-org-4107	1483	25	on	on	IN
en-wikipedia-org-4107	1483	26	symptoms	symptom	NNS
en-wikipedia-org-4107	1483	27	of	of	IN
en-wikipedia-org-4107	1483	28	ADHD	ADHD	NNP
en-wikipedia-org-4107	1483	29	[	[	-LRB-
en-wikipedia-org-4107	1483	30	105,106	105,106	CD
en-wikipedia-org-4107	1483	31	]	]	-RRB-
en-wikipedia-org-4107	1483	32	.	.	.
en-wikipedia-org-4107	1484	1	It	-PRON-	PRP
en-wikipedia-org-4107	1484	2	should	should	MD
en-wikipedia-org-4107	1484	3	be	be	VB
en-wikipedia-org-4107	1484	4	stated	state	VBN
en-wikipedia-org-4107	1484	5	that	that	IN
en-wikipedia-org-4107	1484	6	at	at	IN
en-wikipedia-org-4107	1484	7	this	this	DT
en-wikipedia-org-4107	1484	8	time	time	NN
en-wikipedia-org-4107	1484	9	[	[	-LRB-
en-wikipedia-org-4107	1484	10	supplementation	supplementation	NN
en-wikipedia-org-4107	1484	11	]	]	-RRB-
en-wikipedia-org-4107	1484	12	with	with	IN
en-wikipedia-org-4107	1484	13	zinc	zinc	NN
en-wikipedia-org-4107	1484	14	is	be	VBZ
en-wikipedia-org-4107	1484	15	not	not	RB
en-wikipedia-org-4107	1484	16	integrated	integrate	VBN
en-wikipedia-org-4107	1484	17	in	in	IN
en-wikipedia-org-4107	1484	18	any	any	DT
en-wikipedia-org-4107	1484	19	ADHD	ADHD	NNP
en-wikipedia-org-4107	1484	20	treatment	treatment	NN
en-wikipedia-org-4107	1484	21	algorithm	algorithm	NN
en-wikipedia-org-4107	1484	22	.	.	.
en-wikipedia-org-4107	1485	1	^	^	NNP
en-wikipedia-org-4107	1485	2	a	a	DT
en-wikipedia-org-4107	1485	3	b	b	NN
en-wikipedia-org-4107	1485	4	Scholze	Scholze	NNP
en-wikipedia-org-4107	1485	5	P	P	NNP
en-wikipedia-org-4107	1485	6	,	,	,
en-wikipedia-org-4107	1485	7	Nørregaard	Nørregaard	NNP
en-wikipedia-org-4107	1485	8	L	L	NNP
en-wikipedia-org-4107	1485	9	,	,	,
en-wikipedia-org-4107	1485	10	Singer	Singer	NNP
en-wikipedia-org-4107	1485	11	EA	EA	NNP
en-wikipedia-org-4107	1485	12	,	,	,
en-wikipedia-org-4107	1485	13	Freissmuth	Freissmuth	NNP
en-wikipedia-org-4107	1485	14	M	M	NNP
en-wikipedia-org-4107	1485	15	,	,	,
en-wikipedia-org-4107	1485	16	Gether	Gether	NNP
en-wikipedia-org-4107	1485	17	U	U	NNP
en-wikipedia-org-4107	1485	18	,	,	,
en-wikipedia-org-4107	1485	19	Sitte	Sitte	NNP
en-wikipedia-org-4107	1485	20	HH	HH	NNP
en-wikipedia-org-4107	1485	21	(	(	-LRB-
en-wikipedia-org-4107	1485	22	June	June	NNP
en-wikipedia-org-4107	1485	23	2002	2002	CD
en-wikipedia-org-4107	1485	24	)	)	-RRB-
en-wikipedia-org-4107	1485	25	.	.	.
en-wikipedia-org-4107	1486	1	"	"	``
en-wikipedia-org-4107	1486	2	The	the	DT
en-wikipedia-org-4107	1486	3	role	role	NN
en-wikipedia-org-4107	1486	4	of	of	IN
en-wikipedia-org-4107	1486	5	zinc	zinc	NN
en-wikipedia-org-4107	1486	6	ions	ion	NNS
en-wikipedia-org-4107	1486	7	in	in	IN
en-wikipedia-org-4107	1486	8	reverse	reverse	JJ
en-wikipedia-org-4107	1486	9	transport	transport	NN
en-wikipedia-org-4107	1486	10	mediated	mediate	VBN
en-wikipedia-org-4107	1486	11	by	by	IN
en-wikipedia-org-4107	1486	12	monoamine	monoamine	NN
en-wikipedia-org-4107	1486	13	transporters	transporter	NNS
en-wikipedia-org-4107	1486	14	"	"	''
en-wikipedia-org-4107	1486	15	.	.	.
en-wikipedia-org-4107	1487	1	Journal	Journal	NNP
en-wikipedia-org-4107	1487	2	of	of	IN
en-wikipedia-org-4107	1487	3	Biological	Biological	NNP
en-wikipedia-org-4107	1487	4	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	1487	5	.	.	.
en-wikipedia-org-4107	1488	1	277	277	CD
en-wikipedia-org-4107	1488	2	(	(	-LRB-
en-wikipedia-org-4107	1488	3	24	24	CD
en-wikipedia-org-4107	1488	4	)	)	-RRB-
en-wikipedia-org-4107	1488	5	:	:	:
en-wikipedia-org-4107	1488	6	21505–21513	21505–21513	CD
en-wikipedia-org-4107	1488	7	.	.	.
en-wikipedia-org-4107	1489	1	doi:10.1074	doi:10.1074	VB
en-wikipedia-org-4107	1489	2	/	/	SYM
en-wikipedia-org-4107	1489	3	jbc	jbc	NN
en-wikipedia-org-4107	1489	4	.	.	.
en-wikipedia-org-4107	1489	5	M112265200	M112265200	NNP
en-wikipedia-org-4107	1489	6	.	.	.
en-wikipedia-org-4107	1490	1	PMID	PMID	NNP
en-wikipedia-org-4107	1490	2	 	  	_SP
en-wikipedia-org-4107	1490	3	11940571	11940571	CD
en-wikipedia-org-4107	1490	4	.	.	.
en-wikipedia-org-4107	1491	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1491	2	 	  	_SP
en-wikipedia-org-4107	1491	3	10521850	10521850	CD
en-wikipedia-org-4107	1491	4	.	.	.
en-wikipedia-org-4107	1492	1	The	the	DT
en-wikipedia-org-4107	1492	2	human	human	JJ
en-wikipedia-org-4107	1492	3	dopamine	dopamine	NN
en-wikipedia-org-4107	1492	4	transporter	transporter	NN
en-wikipedia-org-4107	1492	5	(	(	-LRB-
en-wikipedia-org-4107	1492	6	hDAT	hDAT	NNP
en-wikipedia-org-4107	1492	7	)	)	-RRB-
en-wikipedia-org-4107	1492	8	contains	contain	VBZ
en-wikipedia-org-4107	1492	9	an	an	DT
en-wikipedia-org-4107	1492	10	endogenous	endogenous	JJ
en-wikipedia-org-4107	1492	11	high	high	JJ
en-wikipedia-org-4107	1492	12	affinity	affinity	NN
en-wikipedia-org-4107	1492	13	Zn2	zn2	NN
en-wikipedia-org-4107	1492	14	+	+	CC
en-wikipedia-org-4107	1492	15	binding	bind	VBG
en-wikipedia-org-4107	1492	16	site	site	NN
en-wikipedia-org-4107	1492	17	with	with	IN
en-wikipedia-org-4107	1492	18	three	three	CD
en-wikipedia-org-4107	1492	19	coordinating	coordinate	VBG
en-wikipedia-org-4107	1492	20	residues	residue	NNS
en-wikipedia-org-4107	1492	21	on	on	IN
en-wikipedia-org-4107	1492	22	its	-PRON-	PRP$
en-wikipedia-org-4107	1492	23	extracellular	extracellular	JJ
en-wikipedia-org-4107	1492	24	face	face	NN
en-wikipedia-org-4107	1492	25	(	(	-LRB-
en-wikipedia-org-4107	1492	26	His193	his193	UH
en-wikipedia-org-4107	1492	27	,	,	,
en-wikipedia-org-4107	1492	28	His375	his375	CD
en-wikipedia-org-4107	1492	29	,	,	,
en-wikipedia-org-4107	1492	30	and	and	CC
en-wikipedia-org-4107	1492	31	Glu396	glu396	LS
en-wikipedia-org-4107	1492	32	)	)	-RRB-
en-wikipedia-org-4107	1492	33	.	.	.
en-wikipedia-org-4107	1493	1	...	...	NFP
en-wikipedia-org-4107	1494	1	Although	although	IN
en-wikipedia-org-4107	1494	2	Zn2	Zn2	NNP
en-wikipedia-org-4107	1494	3	+	+	CC
en-wikipedia-org-4107	1494	4	inhibited	inhibit	VBN
en-wikipedia-org-4107	1494	5	uptake	uptake	NN
en-wikipedia-org-4107	1494	6	,	,	,
en-wikipedia-org-4107	1494	7	Zn2	Zn2	NNP
en-wikipedia-org-4107	1494	8	+	+	CC
en-wikipedia-org-4107	1494	9	facilitated	facilitate	VBN
en-wikipedia-org-4107	1494	10	[	[	-LRB-
en-wikipedia-org-4107	1494	11	3H]MPP+	3h]mpp+	CD
en-wikipedia-org-4107	1494	12	release	release	NN
en-wikipedia-org-4107	1494	13	induced	induce	VBN
en-wikipedia-org-4107	1494	14	by	by	IN
en-wikipedia-org-4107	1494	15	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1494	16	,	,	,
en-wikipedia-org-4107	1494	17	MPP+	MPP+	NNP
en-wikipedia-org-4107	1494	18	,	,	,
en-wikipedia-org-4107	1494	19	or	or	CC
en-wikipedia-org-4107	1494	20	K+-induced	k+-induced	JJ
en-wikipedia-org-4107	1494	21	depolarization	depolarization	NN
en-wikipedia-org-4107	1494	22	specifically	specifically	RB
en-wikipedia-org-4107	1494	23	at	at	IN
en-wikipedia-org-4107	1494	24	hDAT	hdat	NN
en-wikipedia-org-4107	1494	25	but	but	CC
en-wikipedia-org-4107	1494	26	not	not	RB
en-wikipedia-org-4107	1494	27	at	at	IN
en-wikipedia-org-4107	1494	28	the	the	DT
en-wikipedia-org-4107	1494	29	human	human	JJ
en-wikipedia-org-4107	1494	30	serotonin	serotonin	NN
en-wikipedia-org-4107	1494	31	and	and	CC
en-wikipedia-org-4107	1494	32	the	the	DT
en-wikipedia-org-4107	1494	33	norepinephrine	norepinephrine	NNP
en-wikipedia-org-4107	1494	34	transporter	transporter	NNP
en-wikipedia-org-4107	1494	35	(	(	-LRB-
en-wikipedia-org-4107	1494	36	hNET	hNET	NNP
en-wikipedia-org-4107	1494	37	)	)	-RRB-
en-wikipedia-org-4107	1494	38	.	.	.
en-wikipedia-org-4107	1495	1	...	...	NFP
en-wikipedia-org-4107	1496	1	Surprisingly	surprisingly	RB
en-wikipedia-org-4107	1496	2	,	,	,
en-wikipedia-org-4107	1496	3	this	this	DT
en-wikipedia-org-4107	1496	4	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1496	5	-	-	HYPH
en-wikipedia-org-4107	1496	6	elicited	elicit	VBN
en-wikipedia-org-4107	1496	7	efflux	efflux	NN
en-wikipedia-org-4107	1496	8	was	be	VBD
en-wikipedia-org-4107	1496	9	markedly	markedly	RB
en-wikipedia-org-4107	1496	10	enhanced	enhance	VBN
en-wikipedia-org-4107	1496	11	,	,	,
en-wikipedia-org-4107	1496	12	rather	rather	RB
en-wikipedia-org-4107	1496	13	than	than	IN
en-wikipedia-org-4107	1496	14	inhibited	inhibit	VBN
en-wikipedia-org-4107	1496	15	,	,	,
en-wikipedia-org-4107	1496	16	by	by	IN
en-wikipedia-org-4107	1496	17	the	the	DT
en-wikipedia-org-4107	1496	18	addition	addition	NN
en-wikipedia-org-4107	1496	19	of	of	IN
en-wikipedia-org-4107	1496	20	10	10	CD
en-wikipedia-org-4107	1496	21	 	  	_SP
en-wikipedia-org-4107	1496	22	μM	μm	$
en-wikipedia-org-4107	1496	23	Zn2	Zn2	NNP
en-wikipedia-org-4107	1496	24	+	+	SYM
en-wikipedia-org-4107	1496	25	to	to	IN
en-wikipedia-org-4107	1496	26	the	the	DT
en-wikipedia-org-4107	1496	27	superfusion	superfusion	NN
en-wikipedia-org-4107	1496	28	buffer	buffer	NN
en-wikipedia-org-4107	1496	29	(	(	-LRB-
en-wikipedia-org-4107	1496	30	Fig	fig	NN
en-wikipedia-org-4107	1496	31	.	.	.
en-wikipedia-org-4107	1497	1	2	2	CD
en-wikipedia-org-4107	1497	2	A	a	DT
en-wikipedia-org-4107	1497	3	,	,	,
en-wikipedia-org-4107	1497	4	open	open	JJ
en-wikipedia-org-4107	1497	5	squares	square	NNS
en-wikipedia-org-4107	1497	6	)	)	-RRB-
en-wikipedia-org-4107	1497	7	.	.	.
en-wikipedia-org-4107	1498	1	...	...	NFP
en-wikipedia-org-4107	1499	1	The	the	DT
en-wikipedia-org-4107	1499	2	concentrations	concentration	NNS
en-wikipedia-org-4107	1499	3	of	of	IN
en-wikipedia-org-4107	1499	4	Zn2	Zn2	NNP
en-wikipedia-org-4107	1499	5	+	+	CC
en-wikipedia-org-4107	1499	6	shown	show	VBN
en-wikipedia-org-4107	1499	7	in	in	IN
en-wikipedia-org-4107	1499	8	this	this	DT
en-wikipedia-org-4107	1499	9	study	study	NN
en-wikipedia-org-4107	1499	10	,	,	,
en-wikipedia-org-4107	1499	11	required	require	VBN
en-wikipedia-org-4107	1499	12	for	for	IN
en-wikipedia-org-4107	1499	13	the	the	DT
en-wikipedia-org-4107	1499	14	stimulation	stimulation	NN
en-wikipedia-org-4107	1499	15	of	of	IN
en-wikipedia-org-4107	1499	16	dopamine	dopamine	NN
en-wikipedia-org-4107	1499	17	release	release	NN
en-wikipedia-org-4107	1499	18	(	(	-LRB-
en-wikipedia-org-4107	1499	19	as	as	RB
en-wikipedia-org-4107	1499	20	well	well	RB
en-wikipedia-org-4107	1499	21	as	as	IN
en-wikipedia-org-4107	1499	22	inhibition	inhibition	NN
en-wikipedia-org-4107	1499	23	of	of	IN
en-wikipedia-org-4107	1499	24	uptake	uptake	NN
en-wikipedia-org-4107	1499	25	)	)	-RRB-
en-wikipedia-org-4107	1499	26	,	,	,
en-wikipedia-org-4107	1499	27	covered	cover	VBD
en-wikipedia-org-4107	1499	28	this	this	DT
en-wikipedia-org-4107	1499	29	physiologically	physiologically	RB
en-wikipedia-org-4107	1499	30	relevant	relevant	JJ
en-wikipedia-org-4107	1499	31	range	range	NN
en-wikipedia-org-4107	1499	32	,	,	,
en-wikipedia-org-4107	1499	33	with	with	IN
en-wikipedia-org-4107	1499	34	maximum	maximum	JJ
en-wikipedia-org-4107	1499	35	stimulation	stimulation	NN
en-wikipedia-org-4107	1499	36	occurring	occur	VBG
en-wikipedia-org-4107	1499	37	at	at	IN
en-wikipedia-org-4107	1499	38	3–30	3–30	NNP
en-wikipedia-org-4107	1499	39	 	  	_SP
en-wikipedia-org-4107	1499	40	μM.	μM.	NNP
en-wikipedia-org-4107	1500	1	...	...	NFP
en-wikipedia-org-4107	1501	1	Thus	thus	RB
en-wikipedia-org-4107	1501	2	,	,	,
en-wikipedia-org-4107	1501	3	when	when	WRB
en-wikipedia-org-4107	1501	4	Zn2	Zn2	NNP
en-wikipedia-org-4107	1501	5	+	+	CC
en-wikipedia-org-4107	1501	6	is	be	VBZ
en-wikipedia-org-4107	1501	7	co	co	JJ
en-wikipedia-org-4107	1501	8	-	-	VBN
en-wikipedia-org-4107	1501	9	released	release	VBN
en-wikipedia-org-4107	1501	10	with	with	IN
en-wikipedia-org-4107	1501	11	glutamate	glutamate	NN
en-wikipedia-org-4107	1501	12	,	,	,
en-wikipedia-org-4107	1501	13	it	-PRON-	PRP
en-wikipedia-org-4107	1501	14	may	may	MD
en-wikipedia-org-4107	1501	15	greatly	greatly	RB
en-wikipedia-org-4107	1501	16	augment	augment	VB
en-wikipedia-org-4107	1501	17	the	the	DT
en-wikipedia-org-4107	1501	18	efflux	efflux	NN
en-wikipedia-org-4107	1501	19	of	of	IN
en-wikipedia-org-4107	1501	20	dopamine	dopamine	NN
en-wikipedia-org-4107	1501	21	.	.	.
en-wikipedia-org-4107	1502	1	^	^	NNP
en-wikipedia-org-4107	1502	2	Kahlig	Kahlig	NNP
en-wikipedia-org-4107	1502	3	KM	KM	NNP
en-wikipedia-org-4107	1502	4	,	,	,
en-wikipedia-org-4107	1502	5	Lute	Lute	NNP
en-wikipedia-org-4107	1502	6	BJ	BJ	NNP
en-wikipedia-org-4107	1502	7	,	,	,
en-wikipedia-org-4107	1502	8	Wei	Wei	NNP
en-wikipedia-org-4107	1502	9	Y	Y	NNP
en-wikipedia-org-4107	1502	10	,	,	,
en-wikipedia-org-4107	1502	11	Loland	Loland	NNP
en-wikipedia-org-4107	1502	12	CJ	CJ	NNP
en-wikipedia-org-4107	1502	13	,	,	,
en-wikipedia-org-4107	1502	14	Gether	Gether	NNP
en-wikipedia-org-4107	1502	15	U	U	NNP
en-wikipedia-org-4107	1502	16	,	,	,
en-wikipedia-org-4107	1502	17	Javitch	Javitch	NNP
en-wikipedia-org-4107	1502	18	JA	JA	NNP
en-wikipedia-org-4107	1502	19	,	,	,
en-wikipedia-org-4107	1502	20	Galli	Galli	NNP
en-wikipedia-org-4107	1502	21	A	A	NNP
en-wikipedia-org-4107	1502	22	(	(	-LRB-
en-wikipedia-org-4107	1502	23	August	August	NNP
en-wikipedia-org-4107	1502	24	2006	2006	CD
en-wikipedia-org-4107	1502	25	)	)	-RRB-
en-wikipedia-org-4107	1502	26	.	.	.
en-wikipedia-org-4107	1503	1	"	"	``
en-wikipedia-org-4107	1503	2	Regulation	Regulation	NNP
en-wikipedia-org-4107	1503	3	of	of	IN
en-wikipedia-org-4107	1503	4	dopamine	dopamine	NN
en-wikipedia-org-4107	1503	5	transporter	transporter	NN
en-wikipedia-org-4107	1503	6	trafficking	trafficking	NN
en-wikipedia-org-4107	1503	7	by	by	IN
en-wikipedia-org-4107	1503	8	intracellular	intracellular	NNP
en-wikipedia-org-4107	1503	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1503	10	"	"	''
en-wikipedia-org-4107	1503	11	.	.	.
en-wikipedia-org-4107	1504	1	Molecular	Molecular	NNP
en-wikipedia-org-4107	1504	2	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1504	3	.	.	.
en-wikipedia-org-4107	1505	1	70	70	CD
en-wikipedia-org-4107	1505	2	(	(	-LRB-
en-wikipedia-org-4107	1505	3	2	2	CD
en-wikipedia-org-4107	1505	4	)	)	-RRB-
en-wikipedia-org-4107	1505	5	:	:	:
en-wikipedia-org-4107	1505	6	542–548	542–548	CD
en-wikipedia-org-4107	1505	7	.	.	.
en-wikipedia-org-4107	1506	1	doi:10.1124	doi:10.1124	NNP
en-wikipedia-org-4107	1506	2	/	/	SYM
en-wikipedia-org-4107	1506	3	mol.106.023952	mol.106.023952	NN
en-wikipedia-org-4107	1506	4	.	.	.
en-wikipedia-org-4107	1507	1	PMID	PMID	NNP
en-wikipedia-org-4107	1507	2	 	  	_SP
en-wikipedia-org-4107	1507	3	16684900	16684900	CD
en-wikipedia-org-4107	1507	4	.	.	.
en-wikipedia-org-4107	1508	1	S2CID	S2CID	NNP
en-wikipedia-org-4107	1508	2	 	  	_SP
en-wikipedia-org-4107	1508	3	10317113	10317113	CD
en-wikipedia-org-4107	1508	4	.	.	.
en-wikipedia-org-4107	1509	1	Coadministration	coadministration	NN
en-wikipedia-org-4107	1509	2	of	of	IN
en-wikipedia-org-4107	1509	3	Zn(2	zn(2	CD
en-wikipedia-org-4107	1509	4	+	+	SYM
en-wikipedia-org-4107	1509	5	)	)	-RRB-
en-wikipedia-org-4107	1509	6	and	and	CC
en-wikipedia-org-4107	1509	7	AMPH	AMPH	NNP
en-wikipedia-org-4107	1509	8	consistently	consistently	RB
en-wikipedia-org-4107	1509	9	reduced	reduce	VBD
en-wikipedia-org-4107	1509	10	WT	WT	NNP
en-wikipedia-org-4107	1509	11	-	-	HYPH
en-wikipedia-org-4107	1509	12	hDAT	hdat	NN
en-wikipedia-org-4107	1509	13	trafficking	trafficking	NN
en-wikipedia-org-4107	1509	14	^	^	.
en-wikipedia-org-4107	1509	15	Scassellati	Scassellati	NNP
en-wikipedia-org-4107	1509	16	C	C	NNP
en-wikipedia-org-4107	1509	17	,	,	,
en-wikipedia-org-4107	1509	18	Bonvicini	Bonvicini	NNP
en-wikipedia-org-4107	1509	19	C	C	NNP
en-wikipedia-org-4107	1509	20	,	,	,
en-wikipedia-org-4107	1509	21	Faraone	Faraone	NNP
en-wikipedia-org-4107	1509	22	SV	SV	NNP
en-wikipedia-org-4107	1509	23	,	,	,
en-wikipedia-org-4107	1509	24	Gennarelli	Gennarelli	NNP
en-wikipedia-org-4107	1509	25	M	M	NNP
en-wikipedia-org-4107	1509	26	(	(	-LRB-
en-wikipedia-org-4107	1509	27	October	October	NNP
en-wikipedia-org-4107	1509	28	2012	2012	CD
en-wikipedia-org-4107	1509	29	)	)	-RRB-
en-wikipedia-org-4107	1509	30	.	.	.
en-wikipedia-org-4107	1510	1	"	"	``
en-wikipedia-org-4107	1510	2	Biomarkers	biomarker	NNS
en-wikipedia-org-4107	1510	3	and	and	CC
en-wikipedia-org-4107	1510	4	attention	attention	NN
en-wikipedia-org-4107	1510	5	-	-	HYPH
en-wikipedia-org-4107	1510	6	deficit	deficit	NN
en-wikipedia-org-4107	1510	7	/	/	SYM
en-wikipedia-org-4107	1510	8	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	1510	9	disorder	disorder	NN
en-wikipedia-org-4107	1510	10	:	:	:
en-wikipedia-org-4107	1510	11	a	a	DT
en-wikipedia-org-4107	1510	12	systematic	systematic	JJ
en-wikipedia-org-4107	1510	13	review	review	NN
en-wikipedia-org-4107	1510	14	and	and	CC
en-wikipedia-org-4107	1510	15	meta	meta	NN
en-wikipedia-org-4107	1510	16	-	-	HYPH
en-wikipedia-org-4107	1510	17	analyses	analysis	NNS
en-wikipedia-org-4107	1510	18	"	"	''
en-wikipedia-org-4107	1510	19	.	.	.
en-wikipedia-org-4107	1511	1	Journal	Journal	NNP
en-wikipedia-org-4107	1511	2	of	of	IN
en-wikipedia-org-4107	1511	3	the	the	DT
en-wikipedia-org-4107	1511	4	American	American	NNP
en-wikipedia-org-4107	1511	5	Academy	Academy	NNP
en-wikipedia-org-4107	1511	6	of	of	IN
en-wikipedia-org-4107	1511	7	Child	Child	NNP
en-wikipedia-org-4107	1511	8	&	&	CC
en-wikipedia-org-4107	1511	9	Adolescent	Adolescent	NNP
en-wikipedia-org-4107	1511	10	Psychiatry	Psychiatry	NNP
en-wikipedia-org-4107	1511	11	.	.	.
en-wikipedia-org-4107	1512	1	51	51	CD
en-wikipedia-org-4107	1512	2	(	(	-LRB-
en-wikipedia-org-4107	1512	3	10	10	CD
en-wikipedia-org-4107	1512	4	)	)	-RRB-
en-wikipedia-org-4107	1512	5	:	:	:
en-wikipedia-org-4107	1512	6	1003–1019.e20	1003–1019.e20	CD
en-wikipedia-org-4107	1512	7	.	.	.
en-wikipedia-org-4107	1513	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1513	2	/	/	SYM
en-wikipedia-org-4107	1513	3	j.jaac.2012.08.015	j.jaac.2012.08.015	$
en-wikipedia-org-4107	1513	4	.	.	.
en-wikipedia-org-4107	1514	1	PMID	PMID	NNP
en-wikipedia-org-4107	1514	2	 	  	_SP
en-wikipedia-org-4107	1514	3	23021477	23021477	CD
en-wikipedia-org-4107	1514	4	.	.	.
en-wikipedia-org-4107	1515	1	With	with	IN
en-wikipedia-org-4107	1515	2	regard	regard	NN
en-wikipedia-org-4107	1515	3	to	to	IN
en-wikipedia-org-4107	1515	4	zinc	zinc	NN
en-wikipedia-org-4107	1515	5	supplementation	supplementation	NN
en-wikipedia-org-4107	1515	6	,	,	,
en-wikipedia-org-4107	1515	7	a	a	DT
en-wikipedia-org-4107	1515	8	placebo	placebo	NN
en-wikipedia-org-4107	1515	9	controlled	control	VBN
en-wikipedia-org-4107	1515	10	trial	trial	NN
en-wikipedia-org-4107	1515	11	reported	report	VBD
en-wikipedia-org-4107	1515	12	that	that	IN
en-wikipedia-org-4107	1515	13	doses	dose	VBZ
en-wikipedia-org-4107	1515	14	up	up	RP
en-wikipedia-org-4107	1515	15	to	to	TO
en-wikipedia-org-4107	1515	16	30	30	CD
en-wikipedia-org-4107	1515	17	 	  	_SP
en-wikipedia-org-4107	1515	18	mg	mg	NNP
en-wikipedia-org-4107	1515	19	/	/	SYM
en-wikipedia-org-4107	1515	20	day	day	NN
en-wikipedia-org-4107	1515	21	of	of	IN
en-wikipedia-org-4107	1515	22	zinc	zinc	NN
en-wikipedia-org-4107	1515	23	were	be	VBD
en-wikipedia-org-4107	1515	24	safe	safe	JJ
en-wikipedia-org-4107	1515	25	for	for	IN
en-wikipedia-org-4107	1515	26	at	at	RB
en-wikipedia-org-4107	1515	27	least	least	JJS
en-wikipedia-org-4107	1515	28	8	8	CD
en-wikipedia-org-4107	1515	29	 	  	_SP
en-wikipedia-org-4107	1515	30	weeks	week	NNS
en-wikipedia-org-4107	1515	31	,	,	,
en-wikipedia-org-4107	1515	32	but	but	CC
en-wikipedia-org-4107	1515	33	the	the	DT
en-wikipedia-org-4107	1515	34	clinical	clinical	JJ
en-wikipedia-org-4107	1515	35	effect	effect	NN
en-wikipedia-org-4107	1515	36	was	be	VBD
en-wikipedia-org-4107	1515	37	equivocal	equivocal	JJ
en-wikipedia-org-4107	1515	38	except	except	IN
en-wikipedia-org-4107	1515	39	for	for	IN
en-wikipedia-org-4107	1515	40	the	the	DT
en-wikipedia-org-4107	1515	41	finding	finding	NN
en-wikipedia-org-4107	1515	42	of	of	IN
en-wikipedia-org-4107	1515	43	a	a	DT
en-wikipedia-org-4107	1515	44	37	37	CD
en-wikipedia-org-4107	1515	45	%	%	NN
en-wikipedia-org-4107	1515	46	reduction	reduction	NN
en-wikipedia-org-4107	1515	47	in	in	IN
en-wikipedia-org-4107	1515	48	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1515	49	optimal	optimal	NNP
en-wikipedia-org-4107	1515	50	dose	dose	VBD
en-wikipedia-org-4107	1515	51	with	with	IN
en-wikipedia-org-4107	1515	52	30	30	CD
en-wikipedia-org-4107	1515	53	 	  	_SP
en-wikipedia-org-4107	1515	54	mg	mg	NNP
en-wikipedia-org-4107	1515	55	per	per	IN
en-wikipedia-org-4107	1515	56	day	day	NN
en-wikipedia-org-4107	1515	57	of	of	IN
en-wikipedia-org-4107	1515	58	zinc.110	zinc.110	NNP
en-wikipedia-org-4107	1515	59	^	^	NN
en-wikipedia-org-4107	1515	60	a	a	DT
en-wikipedia-org-4107	1515	61	b	b	NN
en-wikipedia-org-4107	1515	62	c	c	NNP
en-wikipedia-org-4107	1515	63	d	d	NNP
en-wikipedia-org-4107	1515	64	e	e	NNP
en-wikipedia-org-4107	1515	65	f	f	NNP
en-wikipedia-org-4107	1515	66	g	g	NNP
en-wikipedia-org-4107	1515	67	h	h	NNP
en-wikipedia-org-4107	1515	68	i	i	NN
en-wikipedia-org-4107	1515	69	j	j	NNP
en-wikipedia-org-4107	1515	70	k	k	NNP
en-wikipedia-org-4107	1515	71	l	l	NNP
en-wikipedia-org-4107	1515	72	m	m	NNP
en-wikipedia-org-4107	1515	73	n	n	NNP
en-wikipedia-org-4107	1515	74	Eiden	Eiden	NNP
en-wikipedia-org-4107	1515	75	LE	LE	NNP
en-wikipedia-org-4107	1515	76	,	,	,
en-wikipedia-org-4107	1515	77	Weihe	Weihe	NNP
en-wikipedia-org-4107	1515	78	E	e	NN
en-wikipedia-org-4107	1515	79	(	(	-LRB-
en-wikipedia-org-4107	1515	80	January	January	NNP
en-wikipedia-org-4107	1515	81	2011	2011	CD
en-wikipedia-org-4107	1515	82	)	)	-RRB-
en-wikipedia-org-4107	1515	83	.	.	.
en-wikipedia-org-4107	1516	1	"	"	``
en-wikipedia-org-4107	1516	2	VMAT2	VMAT2	NNP
en-wikipedia-org-4107	1516	3	:	:	:
en-wikipedia-org-4107	1516	4	a	a	DT
en-wikipedia-org-4107	1516	5	dynamic	dynamic	JJ
en-wikipedia-org-4107	1516	6	regulator	regulator	NN
en-wikipedia-org-4107	1516	7	of	of	IN
en-wikipedia-org-4107	1516	8	brain	brain	NN
en-wikipedia-org-4107	1516	9	monoaminergic	monoaminergic	JJ
en-wikipedia-org-4107	1516	10	neuronal	neuronal	JJ
en-wikipedia-org-4107	1516	11	function	function	NN
en-wikipedia-org-4107	1516	12	interacting	interact	VBG
en-wikipedia-org-4107	1516	13	with	with	IN
en-wikipedia-org-4107	1516	14	drugs	drug	NNS
en-wikipedia-org-4107	1516	15	of	of	IN
en-wikipedia-org-4107	1516	16	abuse	abuse	NN
en-wikipedia-org-4107	1516	17	"	"	''
en-wikipedia-org-4107	1516	18	.	.	.
en-wikipedia-org-4107	1517	1	Annals	annal	NNS
en-wikipedia-org-4107	1517	2	of	of	IN
en-wikipedia-org-4107	1517	3	the	the	DT
en-wikipedia-org-4107	1517	4	New	New	NNP
en-wikipedia-org-4107	1517	5	York	York	NNP
en-wikipedia-org-4107	1517	6	Academy	Academy	NNP
en-wikipedia-org-4107	1517	7	of	of	IN
en-wikipedia-org-4107	1517	8	Sciences	Sciences	NNPS
en-wikipedia-org-4107	1517	9	.	.	.
en-wikipedia-org-4107	1518	1	1216	1216	CD
en-wikipedia-org-4107	1518	2	(	(	-LRB-
en-wikipedia-org-4107	1518	3	1	1	CD
en-wikipedia-org-4107	1518	4	)	)	-RRB-
en-wikipedia-org-4107	1518	5	:	:	:
en-wikipedia-org-4107	1518	6	86–98	86–98	CD
en-wikipedia-org-4107	1518	7	.	.	.
en-wikipedia-org-4107	1519	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-4107	1519	2	/	/	SYM
en-wikipedia-org-4107	1519	3	j.1749	j.1749	NNP
en-wikipedia-org-4107	1519	4	-	-	HYPH
en-wikipedia-org-4107	1519	5	6632.2010.05906.x	6632.2010.05906.x	NNP
en-wikipedia-org-4107	1519	6	.	.	.
en-wikipedia-org-4107	1520	1	PMC	PMC	NNP
en-wikipedia-org-4107	1520	2	 	  	_SP
en-wikipedia-org-4107	1520	3	4183197	4183197	CD
en-wikipedia-org-4107	1520	4	.	.	.
en-wikipedia-org-4107	1521	1	PMID	PMID	NNP
en-wikipedia-org-4107	1521	2	 	  	_SP
en-wikipedia-org-4107	1521	3	21272013	21272013	CD
en-wikipedia-org-4107	1521	4	.	.	.
en-wikipedia-org-4107	1522	1	VMAT2	VMAT2	NNP
en-wikipedia-org-4107	1522	2	is	be	VBZ
en-wikipedia-org-4107	1522	3	the	the	DT
en-wikipedia-org-4107	1522	4	CNS	CNS	NNP
en-wikipedia-org-4107	1522	5	vesicular	vesicular	JJ
en-wikipedia-org-4107	1522	6	transporter	transporter	NN
en-wikipedia-org-4107	1522	7	for	for	IN
en-wikipedia-org-4107	1522	8	not	not	RB
en-wikipedia-org-4107	1522	9	only	only	RB
en-wikipedia-org-4107	1522	10	the	the	DT
en-wikipedia-org-4107	1522	11	biogenic	biogenic	JJ
en-wikipedia-org-4107	1522	12	amines	amine	NNS
en-wikipedia-org-4107	1522	13	DA	DA	NNP
en-wikipedia-org-4107	1522	14	,	,	,
en-wikipedia-org-4107	1522	15	NE	NE	NNP
en-wikipedia-org-4107	1522	16	,	,	,
en-wikipedia-org-4107	1522	17	EPI	EPI	NNP
en-wikipedia-org-4107	1522	18	,	,	,
en-wikipedia-org-4107	1522	19	5-HT	5-ht	CD
en-wikipedia-org-4107	1522	20	,	,	,
en-wikipedia-org-4107	1522	21	and	and	CC
en-wikipedia-org-4107	1522	22	HIS	his	PRP$
en-wikipedia-org-4107	1522	23	,	,	,
en-wikipedia-org-4107	1522	24	but	but	CC
en-wikipedia-org-4107	1522	25	likely	likely	RB
en-wikipedia-org-4107	1522	26	also	also	RB
en-wikipedia-org-4107	1522	27	for	for	IN
en-wikipedia-org-4107	1522	28	the	the	DT
en-wikipedia-org-4107	1522	29	trace	trace	NN
en-wikipedia-org-4107	1522	30	amines	amine	NNS
en-wikipedia-org-4107	1522	31	TYR	TYR	NNP
en-wikipedia-org-4107	1522	32	,	,	,
en-wikipedia-org-4107	1522	33	PEA	pea	NN
en-wikipedia-org-4107	1522	34	,	,	,
en-wikipedia-org-4107	1522	35	and	and	CC
en-wikipedia-org-4107	1522	36	thyronamine	thyronamine	NN
en-wikipedia-org-4107	1522	37	(	(	-LRB-
en-wikipedia-org-4107	1522	38	THYR	THYR	NNP
en-wikipedia-org-4107	1522	39	)	)	-RRB-
en-wikipedia-org-4107	1522	40	 	  	_SP
en-wikipedia-org-4107	1522	41	...	...	NFP
en-wikipedia-org-4107	1522	42	[	[	-LRB-
en-wikipedia-org-4107	1522	43	Trace	trace	NN
en-wikipedia-org-4107	1522	44	aminergic	aminergic	NN
en-wikipedia-org-4107	1522	45	]	]	-RRB-
en-wikipedia-org-4107	1522	46	neurons	neuron	NNS
en-wikipedia-org-4107	1522	47	in	in	IN
en-wikipedia-org-4107	1522	48	mammalian	mammalian	JJ
en-wikipedia-org-4107	1522	49	CNS	CNS	NNP
en-wikipedia-org-4107	1522	50	would	would	MD
en-wikipedia-org-4107	1522	51	be	be	VB
en-wikipedia-org-4107	1522	52	identifiable	identifiable	JJ
en-wikipedia-org-4107	1522	53	as	as	IN
en-wikipedia-org-4107	1522	54	neurons	neuron	NNS
en-wikipedia-org-4107	1522	55	expressing	express	VBG
en-wikipedia-org-4107	1522	56	VMAT2	vmat2	NN
en-wikipedia-org-4107	1522	57	for	for	IN
en-wikipedia-org-4107	1522	58	storage	storage	NN
en-wikipedia-org-4107	1522	59	,	,	,
en-wikipedia-org-4107	1522	60	and	and	CC
en-wikipedia-org-4107	1522	61	the	the	DT
en-wikipedia-org-4107	1522	62	biosynthetic	biosynthetic	JJ
en-wikipedia-org-4107	1522	63	enzyme	enzyme	NNS
en-wikipedia-org-4107	1522	64	aromatic	aromatic	NNP
en-wikipedia-org-4107	1522	65	amino	amino	NN
en-wikipedia-org-4107	1522	66	acid	acid	NN
en-wikipedia-org-4107	1522	67	decarboxylase	decarboxylase	NNP
en-wikipedia-org-4107	1522	68	(	(	-LRB-
en-wikipedia-org-4107	1522	69	AADC	AADC	NNP
en-wikipedia-org-4107	1522	70	)	)	-RRB-
en-wikipedia-org-4107	1522	71	.	.	.
en-wikipedia-org-4107	1523	1	...	...	NFP
en-wikipedia-org-4107	1523	2	AMPH	AMPH	NNP
en-wikipedia-org-4107	1523	3	release	release	NN
en-wikipedia-org-4107	1523	4	of	of	IN
en-wikipedia-org-4107	1523	5	DA	DA	NNP
en-wikipedia-org-4107	1523	6	from	from	IN
en-wikipedia-org-4107	1523	7	synapses	synapsis	NNS
en-wikipedia-org-4107	1523	8	requires	require	VBZ
en-wikipedia-org-4107	1523	9	both	both	CC
en-wikipedia-org-4107	1523	10	an	an	DT
en-wikipedia-org-4107	1523	11	action	action	NN
en-wikipedia-org-4107	1523	12	at	at	IN
en-wikipedia-org-4107	1523	13	VMAT2	VMAT2	NNS
en-wikipedia-org-4107	1523	14	to	to	TO
en-wikipedia-org-4107	1523	15	release	release	VB
en-wikipedia-org-4107	1523	16	DA	DA	NNP
en-wikipedia-org-4107	1523	17	to	to	IN
en-wikipedia-org-4107	1523	18	the	the	DT
en-wikipedia-org-4107	1523	19	cytoplasm	cytoplasm	NN
en-wikipedia-org-4107	1523	20	and	and	CC
en-wikipedia-org-4107	1523	21	a	a	DT
en-wikipedia-org-4107	1523	22	concerted	concerted	JJ
en-wikipedia-org-4107	1523	23	release	release	NN
en-wikipedia-org-4107	1523	24	of	of	IN
en-wikipedia-org-4107	1523	25	DA	DA	NNP
en-wikipedia-org-4107	1523	26	from	from	IN
en-wikipedia-org-4107	1523	27	the	the	DT
en-wikipedia-org-4107	1523	28	cytoplasm	cytoplasm	NN
en-wikipedia-org-4107	1523	29	via	via	IN
en-wikipedia-org-4107	1523	30	"	"	``
en-wikipedia-org-4107	1523	31	reverse	reverse	JJ
en-wikipedia-org-4107	1523	32	transport	transport	NN
en-wikipedia-org-4107	1523	33	"	"	''
en-wikipedia-org-4107	1523	34	through	through	IN
en-wikipedia-org-4107	1523	35	DAT	DAT	NNP
en-wikipedia-org-4107	1523	36	.	.	.
en-wikipedia-org-4107	1524	1	^	^	NNP
en-wikipedia-org-4107	1524	2	a	a	DT
en-wikipedia-org-4107	1524	3	b	b	NN
en-wikipedia-org-4107	1524	4	c	c	NN
en-wikipedia-org-4107	1524	5	d	d	NNP
en-wikipedia-org-4107	1524	6	Sulzer	Sulzer	NNP
en-wikipedia-org-4107	1524	7	D	d	NN
en-wikipedia-org-4107	1524	8	,	,	,
en-wikipedia-org-4107	1524	9	Cragg	Cragg	NNP
en-wikipedia-org-4107	1524	10	SJ	SJ	NNP
en-wikipedia-org-4107	1524	11	,	,	,
en-wikipedia-org-4107	1524	12	Rice	Rice	NNP
en-wikipedia-org-4107	1524	13	ME	ME	NNP
en-wikipedia-org-4107	1524	14	(	(	-LRB-
en-wikipedia-org-4107	1524	15	August	August	NNP
en-wikipedia-org-4107	1524	16	2016	2016	CD
en-wikipedia-org-4107	1524	17	)	)	-RRB-
en-wikipedia-org-4107	1524	18	.	.	.
en-wikipedia-org-4107	1525	1	"	"	``
en-wikipedia-org-4107	1525	2	Striatal	striatal	JJ
en-wikipedia-org-4107	1525	3	dopamine	dopamine	NN
en-wikipedia-org-4107	1525	4	neurotransmission	neurotransmission	NN
en-wikipedia-org-4107	1525	5	:	:	:
en-wikipedia-org-4107	1525	6	regulation	regulation	NN
en-wikipedia-org-4107	1525	7	of	of	IN
en-wikipedia-org-4107	1525	8	release	release	NN
en-wikipedia-org-4107	1525	9	and	and	CC
en-wikipedia-org-4107	1525	10	uptake	uptake	JJ
en-wikipedia-org-4107	1525	11	"	"	''
en-wikipedia-org-4107	1525	12	.	.	.
en-wikipedia-org-4107	1526	1	Basal	Basal	NNP
en-wikipedia-org-4107	1526	2	Ganglia	Ganglia	NNP
en-wikipedia-org-4107	1526	3	.	.	.
en-wikipedia-org-4107	1527	1	6	6	CD
en-wikipedia-org-4107	1527	2	(	(	-LRB-
en-wikipedia-org-4107	1527	3	3	3	CD
en-wikipedia-org-4107	1527	4	)	)	-RRB-
en-wikipedia-org-4107	1527	5	:	:	:
en-wikipedia-org-4107	1527	6	123–148	123–148	CD
en-wikipedia-org-4107	1527	7	.	.	.
en-wikipedia-org-4107	1528	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1528	2	/	/	SYM
en-wikipedia-org-4107	1528	3	j.baga.2016.02.001	j.baga.2016.02.001	NN
en-wikipedia-org-4107	1528	4	.	.	.
en-wikipedia-org-4107	1529	1	PMC	PMC	NNP
en-wikipedia-org-4107	1529	2	 	  	_SP
en-wikipedia-org-4107	1529	3	4850498	4850498	CD
en-wikipedia-org-4107	1529	4	.	.	.
en-wikipedia-org-4107	1530	1	PMID	PMID	NNP
en-wikipedia-org-4107	1530	2	 	  	_SP
en-wikipedia-org-4107	1530	3	27141430	27141430	CD
en-wikipedia-org-4107	1530	4	.	.	.
en-wikipedia-org-4107	1531	1	Despite	despite	IN
en-wikipedia-org-4107	1531	2	the	the	DT
en-wikipedia-org-4107	1531	3	challenges	challenge	NNS
en-wikipedia-org-4107	1531	4	in	in	IN
en-wikipedia-org-4107	1531	5	determining	determine	VBG
en-wikipedia-org-4107	1531	6	synaptic	synaptic	JJ
en-wikipedia-org-4107	1531	7	vesicle	vesicle	NN
en-wikipedia-org-4107	1531	8	pH	pH	NNP
en-wikipedia-org-4107	1531	9	,	,	,
en-wikipedia-org-4107	1531	10	the	the	DT
en-wikipedia-org-4107	1531	11	proton	proton	NNP
en-wikipedia-org-4107	1531	12	gradient	gradient	NN
en-wikipedia-org-4107	1531	13	across	across	IN
en-wikipedia-org-4107	1531	14	the	the	DT
en-wikipedia-org-4107	1531	15	vesicle	vesicle	NN
en-wikipedia-org-4107	1531	16	membrane	membrane	NN
en-wikipedia-org-4107	1531	17	is	be	VBZ
en-wikipedia-org-4107	1531	18	of	of	IN
en-wikipedia-org-4107	1531	19	fundamental	fundamental	JJ
en-wikipedia-org-4107	1531	20	importance	importance	NN
en-wikipedia-org-4107	1531	21	for	for	IN
en-wikipedia-org-4107	1531	22	its	-PRON-	PRP$
en-wikipedia-org-4107	1531	23	function	function	NN
en-wikipedia-org-4107	1531	24	.	.	.
en-wikipedia-org-4107	1532	1	Exposure	exposure	NN
en-wikipedia-org-4107	1532	2	of	of	IN
en-wikipedia-org-4107	1532	3	isolated	isolated	JJ
en-wikipedia-org-4107	1532	4	catecholamine	catecholamine	NN
en-wikipedia-org-4107	1532	5	vesicles	vesicle	NNS
en-wikipedia-org-4107	1532	6	to	to	TO
en-wikipedia-org-4107	1532	7	protonophores	protonophore	VBZ
en-wikipedia-org-4107	1532	8	collapses	collapse	VBZ
en-wikipedia-org-4107	1532	9	the	the	DT
en-wikipedia-org-4107	1532	10	pH	pH	NNP
en-wikipedia-org-4107	1532	11	gradient	gradient	NN
en-wikipedia-org-4107	1532	12	and	and	CC
en-wikipedia-org-4107	1532	13	rapidly	rapidly	RB
en-wikipedia-org-4107	1532	14	redistributes	redistribute	VBZ
en-wikipedia-org-4107	1532	15	transmitter	transmitter	NN
en-wikipedia-org-4107	1532	16	from	from	IN
en-wikipedia-org-4107	1532	17	inside	inside	RB
en-wikipedia-org-4107	1532	18	to	to	IN
en-wikipedia-org-4107	1532	19	outside	outside	IN
en-wikipedia-org-4107	1532	20	the	the	DT
en-wikipedia-org-4107	1532	21	vesicle	vesicle	NN
en-wikipedia-org-4107	1532	22	.	.	.
en-wikipedia-org-4107	1533	1	...	...	:
en-wikipedia-org-4107	1533	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1533	3	and	and	CC
en-wikipedia-org-4107	1533	4	its	-PRON-	PRP$
en-wikipedia-org-4107	1533	5	derivatives	derivative	NNS
en-wikipedia-org-4107	1533	6	like	like	IN
en-wikipedia-org-4107	1533	7	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	1533	8	are	be	VBP
en-wikipedia-org-4107	1533	9	weak	weak	JJ
en-wikipedia-org-4107	1533	10	base	base	NN
en-wikipedia-org-4107	1533	11	compounds	compound	NNS
en-wikipedia-org-4107	1533	12	that	that	WDT
en-wikipedia-org-4107	1533	13	are	be	VBP
en-wikipedia-org-4107	1533	14	the	the	DT
en-wikipedia-org-4107	1533	15	only	only	JJ
en-wikipedia-org-4107	1533	16	widely	widely	RB
en-wikipedia-org-4107	1533	17	used	use	VBN
en-wikipedia-org-4107	1533	18	class	class	NN
en-wikipedia-org-4107	1533	19	of	of	IN
en-wikipedia-org-4107	1533	20	drugs	drug	NNS
en-wikipedia-org-4107	1533	21	known	know	VBN
en-wikipedia-org-4107	1533	22	to	to	IN
en-wikipedia-org-4107	1533	23	elicit	elicit	JJ
en-wikipedia-org-4107	1533	24	transmitter	transmitter	NN
en-wikipedia-org-4107	1533	25	release	release	NN
en-wikipedia-org-4107	1533	26	by	by	IN
en-wikipedia-org-4107	1533	27	a	a	DT
en-wikipedia-org-4107	1533	28	non	non	JJ
en-wikipedia-org-4107	1533	29	-	-	JJ
en-wikipedia-org-4107	1533	30	exocytic	exocytic	JJ
en-wikipedia-org-4107	1533	31	mechanism	mechanism	NN
en-wikipedia-org-4107	1533	32	.	.	.
en-wikipedia-org-4107	1534	1	As	as	IN
en-wikipedia-org-4107	1534	2	substrates	substrate	NNS
en-wikipedia-org-4107	1534	3	for	for	IN
en-wikipedia-org-4107	1534	4	both	both	DT
en-wikipedia-org-4107	1534	5	DAT	DAT	NNP
en-wikipedia-org-4107	1534	6	and	and	CC
en-wikipedia-org-4107	1534	7	VMAT	VMAT	NNP
en-wikipedia-org-4107	1534	8	,	,	,
en-wikipedia-org-4107	1534	9	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	1534	10	can	can	MD
en-wikipedia-org-4107	1534	11	be	be	VB
en-wikipedia-org-4107	1534	12	taken	take	VBN
en-wikipedia-org-4107	1534	13	up	up	RP
en-wikipedia-org-4107	1534	14	to	to	IN
en-wikipedia-org-4107	1534	15	the	the	DT
en-wikipedia-org-4107	1534	16	cytosol	cytosol	NN
en-wikipedia-org-4107	1534	17	and	and	CC
en-wikipedia-org-4107	1534	18	then	then	RB
en-wikipedia-org-4107	1534	19	sequestered	sequester	VBN
en-wikipedia-org-4107	1534	20	in	in	IN
en-wikipedia-org-4107	1534	21	vesicles	vesicle	NNS
en-wikipedia-org-4107	1534	22	,	,	,
en-wikipedia-org-4107	1534	23	where	where	WRB
en-wikipedia-org-4107	1534	24	they	-PRON-	PRP
en-wikipedia-org-4107	1534	25	act	act	VBP
en-wikipedia-org-4107	1534	26	to	to	TO
en-wikipedia-org-4107	1534	27	collapse	collapse	VB
en-wikipedia-org-4107	1534	28	the	the	DT
en-wikipedia-org-4107	1534	29	vesicular	vesicular	JJ
en-wikipedia-org-4107	1534	30	pH	pH	NNP
en-wikipedia-org-4107	1534	31	gradient	gradient	NN
en-wikipedia-org-4107	1534	32	.	.	.
en-wikipedia-org-4107	1535	1	^	^	NNP
en-wikipedia-org-4107	1535	2	a	a	DT
en-wikipedia-org-4107	1535	3	b	b	NNP
en-wikipedia-org-4107	1535	4	Ledonne	Ledonne	NNP
en-wikipedia-org-4107	1535	5	A	A	NNP
en-wikipedia-org-4107	1535	6	,	,	,
en-wikipedia-org-4107	1535	7	Berretta	Berretta	NNP
en-wikipedia-org-4107	1535	8	N	N	NNP
en-wikipedia-org-4107	1535	9	,	,	,
en-wikipedia-org-4107	1535	10	Davoli	Davoli	NNP
en-wikipedia-org-4107	1535	11	A	A	NNP
en-wikipedia-org-4107	1535	12	,	,	,
en-wikipedia-org-4107	1535	13	Rizzo	Rizzo	NNP
en-wikipedia-org-4107	1535	14	GR	GR	NNP
en-wikipedia-org-4107	1535	15	,	,	,
en-wikipedia-org-4107	1535	16	Bernardi	Bernardi	NNP
en-wikipedia-org-4107	1535	17	G	G	NNP
en-wikipedia-org-4107	1535	18	,	,	,
en-wikipedia-org-4107	1535	19	Mercuri	Mercuri	NNP
en-wikipedia-org-4107	1535	20	NB	NB	NNP
en-wikipedia-org-4107	1535	21	(	(	-LRB-
en-wikipedia-org-4107	1535	22	July	July	NNP
en-wikipedia-org-4107	1535	23	2011	2011	CD
en-wikipedia-org-4107	1535	24	)	)	-RRB-
en-wikipedia-org-4107	1535	25	.	.	.
en-wikipedia-org-4107	1536	1	"	"	``
en-wikipedia-org-4107	1536	2	Electrophysiological	electrophysiological	JJ
en-wikipedia-org-4107	1536	3	effects	effect	NNS
en-wikipedia-org-4107	1536	4	of	of	IN
en-wikipedia-org-4107	1536	5	trace	trace	NN
en-wikipedia-org-4107	1536	6	amines	amine	NNS
en-wikipedia-org-4107	1536	7	on	on	IN
en-wikipedia-org-4107	1536	8	mesencephalic	mesencephalic	JJ
en-wikipedia-org-4107	1536	9	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	1536	10	neurons	neuron	NNS
en-wikipedia-org-4107	1536	11	"	"	''
en-wikipedia-org-4107	1536	12	.	.	.
en-wikipedia-org-4107	1537	1	Frontiers	frontier	NNS
en-wikipedia-org-4107	1537	2	in	in	IN
en-wikipedia-org-4107	1537	3	Systems	system	NNS
en-wikipedia-org-4107	1537	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1537	5	.	.	.
en-wikipedia-org-4107	1538	1	5	5	CD
en-wikipedia-org-4107	1538	2	:	:	SYM
en-wikipedia-org-4107	1538	3	56	56	CD
en-wikipedia-org-4107	1538	4	.	.	.
en-wikipedia-org-4107	1538	5	doi:10.3389	doi:10.3389	NNP
en-wikipedia-org-4107	1538	6	/	/	SYM
en-wikipedia-org-4107	1538	7	fnsys.2011.00056	fnsys.2011.00056	JJ
en-wikipedia-org-4107	1538	8	.	.	.
en-wikipedia-org-4107	1539	1	PMC	PMC	NNP
en-wikipedia-org-4107	1539	2	 	  	_SP
en-wikipedia-org-4107	1539	3	3131148	3131148	CD
en-wikipedia-org-4107	1539	4	.	.	.
en-wikipedia-org-4107	1540	1	PMID	PMID	NNP
en-wikipedia-org-4107	1540	2	 	  	_SP
en-wikipedia-org-4107	1540	3	21772817	21772817	CD
en-wikipedia-org-4107	1540	4	.	.	.
en-wikipedia-org-4107	1541	1	Three	three	CD
en-wikipedia-org-4107	1541	2	important	important	JJ
en-wikipedia-org-4107	1541	3	new	new	JJ
en-wikipedia-org-4107	1541	4	aspects	aspect	NNS
en-wikipedia-org-4107	1541	5	of	of	IN
en-wikipedia-org-4107	1541	6	TAs	ta	NNS
en-wikipedia-org-4107	1541	7	action	action	NN
en-wikipedia-org-4107	1541	8	have	have	VBP
en-wikipedia-org-4107	1541	9	recently	recently	RB
en-wikipedia-org-4107	1541	10	emerged	emerge	VBN
en-wikipedia-org-4107	1541	11	:	:	:
en-wikipedia-org-4107	1541	12	(	(	-LRB-
en-wikipedia-org-4107	1541	13	a	a	LS
en-wikipedia-org-4107	1541	14	)	)	-RRB-
en-wikipedia-org-4107	1541	15	inhibition	inhibition	NN
en-wikipedia-org-4107	1541	16	of	of	IN
en-wikipedia-org-4107	1541	17	firing	fire	VBG
en-wikipedia-org-4107	1541	18	due	due	IN
en-wikipedia-org-4107	1541	19	to	to	IN
en-wikipedia-org-4107	1541	20	increased	increase	VBN
en-wikipedia-org-4107	1541	21	release	release	NN
en-wikipedia-org-4107	1541	22	of	of	IN
en-wikipedia-org-4107	1541	23	dopamine	dopamine	NN
en-wikipedia-org-4107	1541	24	;	;	,
en-wikipedia-org-4107	1541	25	(	(	-LRB-
en-wikipedia-org-4107	1541	26	b	b	NN
en-wikipedia-org-4107	1541	27	)	)	-RRB-
en-wikipedia-org-4107	1541	28	reduction	reduction	NN
en-wikipedia-org-4107	1541	29	of	of	IN
en-wikipedia-org-4107	1541	30	D2	D2	NNP
en-wikipedia-org-4107	1541	31	and	and	CC
en-wikipedia-org-4107	1541	32	GABAB	GABAB	NNP
en-wikipedia-org-4107	1541	33	receptor	receptor	NN
en-wikipedia-org-4107	1541	34	-	-	HYPH
en-wikipedia-org-4107	1541	35	mediated	mediate	VBN
en-wikipedia-org-4107	1541	36	inhibitory	inhibitory	NN
en-wikipedia-org-4107	1541	37	responses	response	NNS
en-wikipedia-org-4107	1541	38	(	(	-LRB-
en-wikipedia-org-4107	1541	39	excitatory	excitatory	NN
en-wikipedia-org-4107	1541	40	effects	effect	NNS
en-wikipedia-org-4107	1541	41	due	due	JJ
en-wikipedia-org-4107	1541	42	to	to	IN
en-wikipedia-org-4107	1541	43	disinhibition	disinhibition	NN
en-wikipedia-org-4107	1541	44	)	)	-RRB-
en-wikipedia-org-4107	1541	45	;	;	:
en-wikipedia-org-4107	1541	46	and	and	CC
en-wikipedia-org-4107	1541	47	(	(	-LRB-
en-wikipedia-org-4107	1541	48	c	c	NN
en-wikipedia-org-4107	1541	49	)	)	-RRB-
en-wikipedia-org-4107	1541	50	a	a	DT
en-wikipedia-org-4107	1541	51	direct	direct	JJ
en-wikipedia-org-4107	1541	52	TA1	TA1	NNP
en-wikipedia-org-4107	1541	53	receptor	receptor	NN
en-wikipedia-org-4107	1541	54	-	-	HYPH
en-wikipedia-org-4107	1541	55	mediated	mediate	VBN
en-wikipedia-org-4107	1541	56	activation	activation	NN
en-wikipedia-org-4107	1541	57	of	of	IN
en-wikipedia-org-4107	1541	58	GIRK	GIRK	NNP
en-wikipedia-org-4107	1541	59	channels	channel	NNS
en-wikipedia-org-4107	1541	60	which	which	WDT
en-wikipedia-org-4107	1541	61	produce	produce	VBP
en-wikipedia-org-4107	1541	62	cell	cell	NN
en-wikipedia-org-4107	1541	63	membrane	membrane	NN
en-wikipedia-org-4107	1541	64	hyperpolarization	hyperpolarization	NN
en-wikipedia-org-4107	1541	65	.	.	.
en-wikipedia-org-4107	1542	1	^	^	NNP
en-wikipedia-org-4107	1542	2	a	a	DT
en-wikipedia-org-4107	1542	3	b	b	NNP
en-wikipedia-org-4107	1542	4	"	"	``
en-wikipedia-org-4107	1542	5	TAAR1	taar1	NN
en-wikipedia-org-4107	1542	6	"	"	''
en-wikipedia-org-4107	1542	7	.	.	.
en-wikipedia-org-4107	1543	1	GenAtlas	GenAtlas	NNP
en-wikipedia-org-4107	1543	2	.	.	.
en-wikipedia-org-4107	1544	1	University	University	NNP
en-wikipedia-org-4107	1544	2	of	of	IN
en-wikipedia-org-4107	1544	3	Paris	Paris	NNP
en-wikipedia-org-4107	1544	4	.	.	.
en-wikipedia-org-4107	1545	1	28	28	CD
en-wikipedia-org-4107	1545	2	January	January	NNP
en-wikipedia-org-4107	1545	3	2012	2012	CD
en-wikipedia-org-4107	1545	4	.	.	.
en-wikipedia-org-4107	1546	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1546	2	29	29	CD
en-wikipedia-org-4107	1546	3	May	May	NNP
en-wikipedia-org-4107	1546	4	2014	2014	CD
en-wikipedia-org-4107	1546	5	.	.	.
en-wikipedia-org-4107	1547	1	•	•	NNP
en-wikipedia-org-4107	1547	2	tonically	tonically	RB
en-wikipedia-org-4107	1547	3	activates	activate	VBZ
en-wikipedia-org-4107	1547	4	inwardly	inwardly	RB
en-wikipedia-org-4107	1547	5	rectifying	rectify	VBG
en-wikipedia-org-4107	1547	6	K(+	K(+	NNP
en-wikipedia-org-4107	1547	7	)	)	-RRB-
en-wikipedia-org-4107	1547	8	channels	channel	NNS
en-wikipedia-org-4107	1547	9	,	,	,
en-wikipedia-org-4107	1547	10	which	which	WDT
en-wikipedia-org-4107	1547	11	reduces	reduce	VBZ
en-wikipedia-org-4107	1547	12	the	the	DT
en-wikipedia-org-4107	1547	13	basal	basal	NN
en-wikipedia-org-4107	1547	14	firing	fire	VBG
en-wikipedia-org-4107	1547	15	frequency	frequency	NN
en-wikipedia-org-4107	1547	16	of	of	IN
en-wikipedia-org-4107	1547	17	dopamine	dopamine	NN
en-wikipedia-org-4107	1547	18	(	(	-LRB-
en-wikipedia-org-4107	1547	19	DA	DA	NNP
en-wikipedia-org-4107	1547	20	)	)	-RRB-
en-wikipedia-org-4107	1547	21	neurons	neuron	NNS
en-wikipedia-org-4107	1547	22	of	of	IN
en-wikipedia-org-4107	1547	23	the	the	DT
en-wikipedia-org-4107	1547	24	ventral	ventral	JJ
en-wikipedia-org-4107	1547	25	tegmental	tegmental	JJ
en-wikipedia-org-4107	1547	26	area	area	NN
en-wikipedia-org-4107	1547	27	(	(	-LRB-
en-wikipedia-org-4107	1547	28	VTA	VTA	NNP
en-wikipedia-org-4107	1547	29	)	)	-RRB-
en-wikipedia-org-4107	1547	30	^	^	FW
en-wikipedia-org-4107	1547	31	a	a	DT
en-wikipedia-org-4107	1547	32	b	b	NN
en-wikipedia-org-4107	1547	33	c	c	NNP
en-wikipedia-org-4107	1547	34	d	d	NN
en-wikipedia-org-4107	1547	35	e	e	NNP
en-wikipedia-org-4107	1547	36	f	f	NNP
en-wikipedia-org-4107	1547	37	Underhill	Underhill	NNP
en-wikipedia-org-4107	1547	38	SM	SM	NNP
en-wikipedia-org-4107	1547	39	,	,	,
en-wikipedia-org-4107	1547	40	Wheeler	Wheeler	NNP
en-wikipedia-org-4107	1547	41	DS	DS	NNP
en-wikipedia-org-4107	1547	42	,	,	,
en-wikipedia-org-4107	1547	43	Li	Li	NNP
en-wikipedia-org-4107	1547	44	M	M	NNP
en-wikipedia-org-4107	1547	45	,	,	,
en-wikipedia-org-4107	1547	46	Watts	Watts	NNP
en-wikipedia-org-4107	1547	47	SD	SD	NNP
en-wikipedia-org-4107	1547	48	,	,	,
en-wikipedia-org-4107	1547	49	Ingram	Ingram	NNP
en-wikipedia-org-4107	1547	50	SL	SL	NNP
en-wikipedia-org-4107	1547	51	,	,	,
en-wikipedia-org-4107	1547	52	Amara	Amara	NNP
en-wikipedia-org-4107	1547	53	SG	SG	NNP
en-wikipedia-org-4107	1547	54	(	(	-LRB-
en-wikipedia-org-4107	1547	55	July	July	NNP
en-wikipedia-org-4107	1547	56	2014	2014	CD
en-wikipedia-org-4107	1547	57	)	)	-RRB-
en-wikipedia-org-4107	1547	58	.	.	.
en-wikipedia-org-4107	1548	1	"	"	``
en-wikipedia-org-4107	1548	2	Amphetamine	amphetamine	NN
en-wikipedia-org-4107	1548	3	modulates	modulate	VBZ
en-wikipedia-org-4107	1548	4	excitatory	excitatory	NN
en-wikipedia-org-4107	1548	5	neurotransmission	neurotransmission	NN
en-wikipedia-org-4107	1548	6	through	through	IN
en-wikipedia-org-4107	1548	7	endocytosis	endocytosis	NN
en-wikipedia-org-4107	1548	8	of	of	IN
en-wikipedia-org-4107	1548	9	the	the	DT
en-wikipedia-org-4107	1548	10	glutamate	glutamate	JJ
en-wikipedia-org-4107	1548	11	transporter	transporter	NN
en-wikipedia-org-4107	1548	12	EAAT3	eaat3	NN
en-wikipedia-org-4107	1548	13	in	in	IN
en-wikipedia-org-4107	1548	14	dopamine	dopamine	NN
en-wikipedia-org-4107	1548	15	neurons	neuron	NNS
en-wikipedia-org-4107	1548	16	"	"	''
en-wikipedia-org-4107	1548	17	.	.	.
en-wikipedia-org-4107	1549	1	Neuron	neuron	UH
en-wikipedia-org-4107	1549	2	.	.	.
en-wikipedia-org-4107	1550	1	83	83	CD
en-wikipedia-org-4107	1550	2	(	(	-LRB-
en-wikipedia-org-4107	1550	3	2	2	CD
en-wikipedia-org-4107	1550	4	)	)	-RRB-
en-wikipedia-org-4107	1550	5	:	:	:
en-wikipedia-org-4107	1550	6	404–416	404–416	CD
en-wikipedia-org-4107	1550	7	.	.	.
en-wikipedia-org-4107	1551	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1551	2	/	/	SYM
en-wikipedia-org-4107	1551	3	j.neuron.2014.05.043	j.neuron.2014.05.043	CD
en-wikipedia-org-4107	1551	4	.	.	.
en-wikipedia-org-4107	1552	1	PMC	PMC	NNP
en-wikipedia-org-4107	1552	2	 	  	_SP
en-wikipedia-org-4107	1552	3	4159050	4159050	CD
en-wikipedia-org-4107	1552	4	.	.	.
en-wikipedia-org-4107	1553	1	PMID	PMID	NNP
en-wikipedia-org-4107	1553	2	 	  	_SP
en-wikipedia-org-4107	1553	3	25033183	25033183	CD
en-wikipedia-org-4107	1553	4	.	.	.
en-wikipedia-org-4107	1554	1	AMPH	AMPH	NNP
en-wikipedia-org-4107	1554	2	also	also	RB
en-wikipedia-org-4107	1554	3	increases	increase	VBZ
en-wikipedia-org-4107	1554	4	intracellular	intracellular	JJ
en-wikipedia-org-4107	1554	5	calcium	calcium	NN
en-wikipedia-org-4107	1554	6	(	(	-LRB-
en-wikipedia-org-4107	1554	7	Gnegy	Gnegy	NNP
en-wikipedia-org-4107	1554	8	et	et	NNP
en-wikipedia-org-4107	1554	9	al	al	NNP
en-wikipedia-org-4107	1554	10	.	.	NNP
en-wikipedia-org-4107	1554	11	,	,	,
en-wikipedia-org-4107	1554	12	2004	2004	CD
en-wikipedia-org-4107	1554	13	)	)	-RRB-
en-wikipedia-org-4107	1554	14	that	that	WDT
en-wikipedia-org-4107	1554	15	is	be	VBZ
en-wikipedia-org-4107	1554	16	associated	associate	VBN
en-wikipedia-org-4107	1554	17	with	with	IN
en-wikipedia-org-4107	1554	18	calmodulin	calmodulin	NNP
en-wikipedia-org-4107	1554	19	/	/	SYM
en-wikipedia-org-4107	1554	20	CamKII	CamKII	NNP
en-wikipedia-org-4107	1554	21	activation	activation	NN
en-wikipedia-org-4107	1554	22	(	(	-LRB-
en-wikipedia-org-4107	1554	23	Wei	Wei	NNP
en-wikipedia-org-4107	1554	24	et	et	NNP
en-wikipedia-org-4107	1554	25	al	al	NNP
en-wikipedia-org-4107	1554	26	.	.	NNP
en-wikipedia-org-4107	1554	27	,	,	,
en-wikipedia-org-4107	1554	28	2007	2007	CD
en-wikipedia-org-4107	1554	29	)	)	-RRB-
en-wikipedia-org-4107	1554	30	and	and	CC
en-wikipedia-org-4107	1554	31	modulation	modulation	NN
en-wikipedia-org-4107	1554	32	and	and	CC
en-wikipedia-org-4107	1554	33	trafficking	trafficking	NN
en-wikipedia-org-4107	1554	34	of	of	IN
en-wikipedia-org-4107	1554	35	the	the	DT
en-wikipedia-org-4107	1554	36	DAT	DAT	NNP
en-wikipedia-org-4107	1554	37	(	(	-LRB-
en-wikipedia-org-4107	1554	38	Fog	Fog	NNP
en-wikipedia-org-4107	1554	39	et	et	NNP
en-wikipedia-org-4107	1554	40	al	al	NNP
en-wikipedia-org-4107	1554	41	.	.	NNP
en-wikipedia-org-4107	1554	42	,	,	,
en-wikipedia-org-4107	1554	43	2006	2006	CD
en-wikipedia-org-4107	1554	44	;	;	:
en-wikipedia-org-4107	1554	45	Sakrikar	Sakrikar	NNP
en-wikipedia-org-4107	1554	46	et	et	NNP
en-wikipedia-org-4107	1554	47	al	al	NNP
en-wikipedia-org-4107	1554	48	.	.	NNP
en-wikipedia-org-4107	1554	49	,	,	,
en-wikipedia-org-4107	1554	50	2012	2012	CD
en-wikipedia-org-4107	1554	51	)	)	-RRB-
en-wikipedia-org-4107	1554	52	.	.	.
en-wikipedia-org-4107	1555	1	...	...	:
en-wikipedia-org-4107	1555	2	For	for	IN
en-wikipedia-org-4107	1555	3	example	example	NN
en-wikipedia-org-4107	1555	4	,	,	,
en-wikipedia-org-4107	1555	5	AMPH	AMPH	NNP
en-wikipedia-org-4107	1555	6	increases	increase	VBZ
en-wikipedia-org-4107	1555	7	extracellular	extracellular	NNP
en-wikipedia-org-4107	1555	8	glutamate	glutamate	NN
en-wikipedia-org-4107	1555	9	in	in	IN
en-wikipedia-org-4107	1555	10	various	various	JJ
en-wikipedia-org-4107	1555	11	brain	brain	NN
en-wikipedia-org-4107	1555	12	regions	region	NNS
en-wikipedia-org-4107	1555	13	including	include	VBG
en-wikipedia-org-4107	1555	14	the	the	DT
en-wikipedia-org-4107	1555	15	striatum	striatum	NN
en-wikipedia-org-4107	1555	16	,	,	,
en-wikipedia-org-4107	1555	17	VTA	VTA	NNP
en-wikipedia-org-4107	1555	18	and	and	CC
en-wikipedia-org-4107	1555	19	NAc	NAc	NNS
en-wikipedia-org-4107	1555	20	(	(	-LRB-
en-wikipedia-org-4107	1555	21	Del	Del	NNP
en-wikipedia-org-4107	1555	22	Arco	Arco	NNP
en-wikipedia-org-4107	1555	23	et	et	FW
en-wikipedia-org-4107	1555	24	al	al	NNP
en-wikipedia-org-4107	1555	25	.	.	NNP
en-wikipedia-org-4107	1555	26	,	,	,
en-wikipedia-org-4107	1555	27	1999	1999	CD
en-wikipedia-org-4107	1555	28	;	;	:
en-wikipedia-org-4107	1555	29	Kim	Kim	NNP
en-wikipedia-org-4107	1555	30	et	et	FW
en-wikipedia-org-4107	1555	31	al	al	NNP
en-wikipedia-org-4107	1555	32	.	.	NNP
en-wikipedia-org-4107	1555	33	,	,	,
en-wikipedia-org-4107	1555	34	1981	1981	CD
en-wikipedia-org-4107	1555	35	;	;	:
en-wikipedia-org-4107	1555	36	Mora	Mora	NNP
en-wikipedia-org-4107	1555	37	and	and	CC
en-wikipedia-org-4107	1555	38	Porras	Porras	NNP
en-wikipedia-org-4107	1555	39	,	,	,
en-wikipedia-org-4107	1555	40	1993	1993	CD
en-wikipedia-org-4107	1555	41	;	;	:
en-wikipedia-org-4107	1555	42	Xue	Xue	NNP
en-wikipedia-org-4107	1555	43	et	et	FW
en-wikipedia-org-4107	1555	44	al	al	NNP
en-wikipedia-org-4107	1555	45	.	.	NNP
en-wikipedia-org-4107	1555	46	,	,	,
en-wikipedia-org-4107	1555	47	1996	1996	CD
en-wikipedia-org-4107	1555	48	)	)	-RRB-
en-wikipedia-org-4107	1555	49	,	,	,
en-wikipedia-org-4107	1555	50	but	but	CC
en-wikipedia-org-4107	1555	51	it	-PRON-	PRP
en-wikipedia-org-4107	1555	52	has	have	VBZ
en-wikipedia-org-4107	1555	53	not	not	RB
en-wikipedia-org-4107	1555	54	been	be	VBN
en-wikipedia-org-4107	1555	55	established	establish	VBN
en-wikipedia-org-4107	1555	56	whether	whether	IN
en-wikipedia-org-4107	1555	57	this	this	DT
en-wikipedia-org-4107	1555	58	change	change	NN
en-wikipedia-org-4107	1555	59	can	can	MD
en-wikipedia-org-4107	1555	60	be	be	VB
en-wikipedia-org-4107	1555	61	explained	explain	VBN
en-wikipedia-org-4107	1555	62	by	by	IN
en-wikipedia-org-4107	1555	63	increased	increase	VBN
en-wikipedia-org-4107	1555	64	synaptic	synaptic	JJ
en-wikipedia-org-4107	1555	65	release	release	NN
en-wikipedia-org-4107	1555	66	or	or	CC
en-wikipedia-org-4107	1555	67	by	by	IN
en-wikipedia-org-4107	1555	68	reduced	reduced	JJ
en-wikipedia-org-4107	1555	69	clearance	clearance	NN
en-wikipedia-org-4107	1555	70	of	of	IN
en-wikipedia-org-4107	1555	71	glutamate	glutamate	NN
en-wikipedia-org-4107	1555	72	.	.	.
en-wikipedia-org-4107	1556	1	...	...	:
en-wikipedia-org-4107	1556	2	DHK	dhk	NN
en-wikipedia-org-4107	1556	3	-	-	HYPH
en-wikipedia-org-4107	1556	4	sensitive	sensitive	JJ
en-wikipedia-org-4107	1556	5	,	,	,
en-wikipedia-org-4107	1556	6	EAAT2	EAAT2	''
en-wikipedia-org-4107	1556	7	uptake	uptake	NN
en-wikipedia-org-4107	1556	8	was	be	VBD
en-wikipedia-org-4107	1556	9	not	not	RB
en-wikipedia-org-4107	1556	10	altered	alter	VBN
en-wikipedia-org-4107	1556	11	by	by	IN
en-wikipedia-org-4107	1556	12	AMPH	AMPH	NNP
en-wikipedia-org-4107	1556	13	(	(	-LRB-
en-wikipedia-org-4107	1556	14	Figure	Figure	NNP
en-wikipedia-org-4107	1556	15	1A	1a	NN
en-wikipedia-org-4107	1556	16	)	)	-RRB-
en-wikipedia-org-4107	1556	17	.	.	.
en-wikipedia-org-4107	1557	1	The	the	DT
en-wikipedia-org-4107	1557	2	remaining	remain	VBG
en-wikipedia-org-4107	1557	3	glutamate	glutamate	JJ
en-wikipedia-org-4107	1557	4	transport	transport	NN
en-wikipedia-org-4107	1557	5	in	in	IN
en-wikipedia-org-4107	1557	6	these	these	DT
en-wikipedia-org-4107	1557	7	midbrain	midbrain	NN
en-wikipedia-org-4107	1557	8	cultures	culture	NNS
en-wikipedia-org-4107	1557	9	is	be	VBZ
en-wikipedia-org-4107	1557	10	likely	likely	RB
en-wikipedia-org-4107	1557	11	mediated	mediate	VBN
en-wikipedia-org-4107	1557	12	by	by	IN
en-wikipedia-org-4107	1557	13	EAAT3	eaat3	UH
en-wikipedia-org-4107	1557	14	and	and	CC
en-wikipedia-org-4107	1557	15	this	this	DT
en-wikipedia-org-4107	1557	16	component	component	NN
en-wikipedia-org-4107	1557	17	was	be	VBD
en-wikipedia-org-4107	1557	18	significantly	significantly	RB
en-wikipedia-org-4107	1557	19	decreased	decrease	VBN
en-wikipedia-org-4107	1557	20	by	by	IN
en-wikipedia-org-4107	1557	21	AMPH	AMPH	NNP
en-wikipedia-org-4107	1557	22	^	^	NNP
en-wikipedia-org-4107	1557	23	a	a	DT
en-wikipedia-org-4107	1557	24	b	b	NN
en-wikipedia-org-4107	1557	25	Vaughan	Vaughan	NNP
en-wikipedia-org-4107	1557	26	RA	RA	NNP
en-wikipedia-org-4107	1557	27	,	,	,
en-wikipedia-org-4107	1557	28	Foster	Foster	NNP
en-wikipedia-org-4107	1557	29	JD	JD	NNP
en-wikipedia-org-4107	1557	30	(	(	-LRB-
en-wikipedia-org-4107	1557	31	September	September	NNP
en-wikipedia-org-4107	1557	32	2013	2013	CD
en-wikipedia-org-4107	1557	33	)	)	-RRB-
en-wikipedia-org-4107	1557	34	.	.	.
en-wikipedia-org-4107	1558	1	"	"	``
en-wikipedia-org-4107	1558	2	Mechanisms	Mechanisms	NNPS
en-wikipedia-org-4107	1558	3	of	of	IN
en-wikipedia-org-4107	1558	4	dopamine	dopamine	NN
en-wikipedia-org-4107	1558	5	transporter	transporter	NN
en-wikipedia-org-4107	1558	6	regulation	regulation	NN
en-wikipedia-org-4107	1558	7	in	in	IN
en-wikipedia-org-4107	1558	8	normal	normal	JJ
en-wikipedia-org-4107	1558	9	and	and	CC
en-wikipedia-org-4107	1558	10	disease	disease	NN
en-wikipedia-org-4107	1558	11	states	state	NNS
en-wikipedia-org-4107	1558	12	"	"	''
en-wikipedia-org-4107	1558	13	.	.	.
en-wikipedia-org-4107	1559	1	Trends	trend	NNS
en-wikipedia-org-4107	1559	2	in	in	IN
en-wikipedia-org-4107	1559	3	Pharmacological	Pharmacological	NNP
en-wikipedia-org-4107	1559	4	Sciences	Sciences	NNPS
en-wikipedia-org-4107	1559	5	.	.	.
en-wikipedia-org-4107	1560	1	34	34	CD
en-wikipedia-org-4107	1560	2	(	(	-LRB-
en-wikipedia-org-4107	1560	3	9	9	CD
en-wikipedia-org-4107	1560	4	)	)	-RRB-
en-wikipedia-org-4107	1560	5	:	:	:
en-wikipedia-org-4107	1560	6	489–496	489–496	CD
en-wikipedia-org-4107	1560	7	.	.	.
en-wikipedia-org-4107	1561	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1561	2	/	/	SYM
en-wikipedia-org-4107	1561	3	j.tips.2013.07.005	j.tips.2013.07.005	NNP
en-wikipedia-org-4107	1561	4	.	.	.
en-wikipedia-org-4107	1562	1	PMC	PMC	NNP
en-wikipedia-org-4107	1562	2	 	  	_SP
en-wikipedia-org-4107	1562	3	3831354	3831354	CD
en-wikipedia-org-4107	1562	4	.	.	.
en-wikipedia-org-4107	1563	1	PMID	PMID	NNP
en-wikipedia-org-4107	1563	2	 	  	_SP
en-wikipedia-org-4107	1563	3	23968642	23968642	CD
en-wikipedia-org-4107	1563	4	.	.	.
en-wikipedia-org-4107	1564	1	AMPH	AMPH	NNP
en-wikipedia-org-4107	1564	2	and	and	CC
en-wikipedia-org-4107	1564	3	METH	METH	NNP
en-wikipedia-org-4107	1564	4	also	also	RB
en-wikipedia-org-4107	1564	5	stimulate	stimulate	VBP
en-wikipedia-org-4107	1564	6	DA	DA	NNP
en-wikipedia-org-4107	1564	7	efflux	efflux	NN
en-wikipedia-org-4107	1564	8	,	,	,
en-wikipedia-org-4107	1564	9	which	which	WDT
en-wikipedia-org-4107	1564	10	is	be	VBZ
en-wikipedia-org-4107	1564	11	thought	think	VBN
en-wikipedia-org-4107	1564	12	to	to	TO
en-wikipedia-org-4107	1564	13	be	be	VB
en-wikipedia-org-4107	1564	14	a	a	DT
en-wikipedia-org-4107	1564	15	crucial	crucial	JJ
en-wikipedia-org-4107	1564	16	element	element	NN
en-wikipedia-org-4107	1564	17	in	in	IN
en-wikipedia-org-4107	1564	18	their	-PRON-	PRP$
en-wikipedia-org-4107	1564	19	addictive	addictive	JJ
en-wikipedia-org-4107	1564	20	properties	property	NNS
en-wikipedia-org-4107	1564	21	[	[	-LRB-
en-wikipedia-org-4107	1564	22	80	80	CD
en-wikipedia-org-4107	1564	23	]	]	-RRB-
en-wikipedia-org-4107	1564	24	,	,	,
en-wikipedia-org-4107	1564	25	although	although	IN
en-wikipedia-org-4107	1564	26	the	the	DT
en-wikipedia-org-4107	1564	27	mechanisms	mechanism	NNS
en-wikipedia-org-4107	1564	28	do	do	VBP
en-wikipedia-org-4107	1564	29	not	not	RB
en-wikipedia-org-4107	1564	30	appear	appear	VB
en-wikipedia-org-4107	1564	31	to	to	TO
en-wikipedia-org-4107	1564	32	be	be	VB
en-wikipedia-org-4107	1564	33	identical	identical	JJ
en-wikipedia-org-4107	1564	34	for	for	IN
en-wikipedia-org-4107	1564	35	each	each	DT
en-wikipedia-org-4107	1564	36	drug	drug	NN
en-wikipedia-org-4107	1564	37	[	[	-LRB-
en-wikipedia-org-4107	1564	38	81	81	CD
en-wikipedia-org-4107	1564	39	]	]	-RRB-
en-wikipedia-org-4107	1564	40	.	.	.
en-wikipedia-org-4107	1565	1	These	these	DT
en-wikipedia-org-4107	1565	2	processes	process	NNS
en-wikipedia-org-4107	1565	3	are	be	VBP
en-wikipedia-org-4107	1565	4	PKCβ	PKCβ	NNS
en-wikipedia-org-4107	1565	5	–	–	:
en-wikipedia-org-4107	1565	6	and	and	CC
en-wikipedia-org-4107	1565	7	CaMK	camk	NN
en-wikipedia-org-4107	1565	8	–	–	:
en-wikipedia-org-4107	1565	9	dependent	dependent	JJ
en-wikipedia-org-4107	1565	10	[	[	-LRB-
en-wikipedia-org-4107	1565	11	72	72	CD
en-wikipedia-org-4107	1565	12	,	,	,
en-wikipedia-org-4107	1565	13	82	82	CD
en-wikipedia-org-4107	1565	14	]	]	-RRB-
en-wikipedia-org-4107	1565	15	,	,	,
en-wikipedia-org-4107	1565	16	and	and	CC
en-wikipedia-org-4107	1565	17	PKCβ	PKCβ	NNPS
en-wikipedia-org-4107	1565	18	knock	knock	VB
en-wikipedia-org-4107	1565	19	-	-	HYPH
en-wikipedia-org-4107	1565	20	out	out	RP
en-wikipedia-org-4107	1565	21	mice	mouse	NNS
en-wikipedia-org-4107	1565	22	display	display	NN
en-wikipedia-org-4107	1565	23	decreased	decrease	VBD
en-wikipedia-org-4107	1565	24	AMPH	AMPH	NNP
en-wikipedia-org-4107	1565	25	-	-	HYPH
en-wikipedia-org-4107	1565	26	induced	induce	VBN
en-wikipedia-org-4107	1565	27	efflux	efflux	NN
en-wikipedia-org-4107	1565	28	that	that	WDT
en-wikipedia-org-4107	1565	29	correlates	correlate	VBZ
en-wikipedia-org-4107	1565	30	with	with	IN
en-wikipedia-org-4107	1565	31	reduced	reduced	JJ
en-wikipedia-org-4107	1565	32	AMPH	AMPH	NNP
en-wikipedia-org-4107	1565	33	-	-	HYPH
en-wikipedia-org-4107	1565	34	induced	induce	VBN
en-wikipedia-org-4107	1565	35	locomotion	locomotion	NN
en-wikipedia-org-4107	1565	36	[	[	-LRB-
en-wikipedia-org-4107	1565	37	72	72	CD
en-wikipedia-org-4107	1565	38	]	]	-RRB-
en-wikipedia-org-4107	1565	39	.	.	.
en-wikipedia-org-4107	1566	1	^	^	NNP
en-wikipedia-org-4107	1566	2	a	a	DT
en-wikipedia-org-4107	1566	3	b	b	NN
en-wikipedia-org-4107	1566	4	Maguire	Maguire	NNP
en-wikipedia-org-4107	1566	5	JJ	JJ	NNP
en-wikipedia-org-4107	1566	6	,	,	,
en-wikipedia-org-4107	1566	7	Davenport	Davenport	NNP
en-wikipedia-org-4107	1566	8	AP	AP	NNP
en-wikipedia-org-4107	1566	9	(	(	-LRB-
en-wikipedia-org-4107	1566	10	2	2	CD
en-wikipedia-org-4107	1566	11	December	December	NNP
en-wikipedia-org-4107	1566	12	2014	2014	CD
en-wikipedia-org-4107	1566	13	)	)	-RRB-
en-wikipedia-org-4107	1566	14	.	.	.
en-wikipedia-org-4107	1567	1	"	"	``
en-wikipedia-org-4107	1567	2	TA1	TA1	NNP
en-wikipedia-org-4107	1567	3	receptor	receptor	NN
en-wikipedia-org-4107	1567	4	"	"	''
en-wikipedia-org-4107	1567	5	.	.	.
en-wikipedia-org-4107	1568	1	IUPHAR	IUPHAR	NNP
en-wikipedia-org-4107	1568	2	database	database	NN
en-wikipedia-org-4107	1568	3	.	.	.
en-wikipedia-org-4107	1569	1	International	International	NNP
en-wikipedia-org-4107	1569	2	Union	Union	NNP
en-wikipedia-org-4107	1569	3	of	of	IN
en-wikipedia-org-4107	1569	4	Basic	Basic	NNP
en-wikipedia-org-4107	1569	5	and	and	CC
en-wikipedia-org-4107	1569	6	Clinical	Clinical	NNP
en-wikipedia-org-4107	1569	7	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1569	8	.	.	.
en-wikipedia-org-4107	1570	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1570	2	8	8	CD
en-wikipedia-org-4107	1570	3	December	December	NNP
en-wikipedia-org-4107	1570	4	2014	2014	CD
en-wikipedia-org-4107	1570	5	.	.	.
en-wikipedia-org-4107	1571	1	^	^	NNP
en-wikipedia-org-4107	1571	2	Borowsky	Borowsky	NNP
en-wikipedia-org-4107	1571	3	B	B	NNP
en-wikipedia-org-4107	1571	4	,	,	,
en-wikipedia-org-4107	1571	5	Adham	Adham	NNP
en-wikipedia-org-4107	1571	6	N	N	NNP
en-wikipedia-org-4107	1571	7	,	,	,
en-wikipedia-org-4107	1571	8	Jones	Jones	NNP
en-wikipedia-org-4107	1571	9	KA	KA	NNP
en-wikipedia-org-4107	1571	10	,	,	,
en-wikipedia-org-4107	1571	11	Raddatz	Raddatz	NNP
en-wikipedia-org-4107	1571	12	R	R	NNP
en-wikipedia-org-4107	1571	13	,	,	,
en-wikipedia-org-4107	1571	14	Artymyshyn	Artymyshyn	NNP
en-wikipedia-org-4107	1571	15	R	R	NNP
en-wikipedia-org-4107	1571	16	,	,	,
en-wikipedia-org-4107	1571	17	Ogozalek	Ogozalek	NNP
en-wikipedia-org-4107	1571	18	KL	KL	NNP
en-wikipedia-org-4107	1571	19	,	,	,
en-wikipedia-org-4107	1571	20	Durkin	Durkin	NNP
en-wikipedia-org-4107	1571	21	MM	MM	NNP
en-wikipedia-org-4107	1571	22	,	,	,
en-wikipedia-org-4107	1571	23	Lakhlani	Lakhlani	NNP
en-wikipedia-org-4107	1571	24	PP	PP	NNP
en-wikipedia-org-4107	1571	25	,	,	,
en-wikipedia-org-4107	1571	26	Bonini	Bonini	NNP
en-wikipedia-org-4107	1571	27	JA	JA	NNP
en-wikipedia-org-4107	1571	28	,	,	,
en-wikipedia-org-4107	1571	29	Pathirana	Pathirana	NNP
en-wikipedia-org-4107	1571	30	S	S	NNP
en-wikipedia-org-4107	1571	31	,	,	,
en-wikipedia-org-4107	1571	32	Boyle	Boyle	NNP
en-wikipedia-org-4107	1571	33	N	N	NNP
en-wikipedia-org-4107	1571	34	,	,	,
en-wikipedia-org-4107	1571	35	Pu	Pu	NNP
en-wikipedia-org-4107	1571	36	X	X	NNP
en-wikipedia-org-4107	1571	37	,	,	,
en-wikipedia-org-4107	1571	38	Kouranova	Kouranova	NNP
en-wikipedia-org-4107	1571	39	E	E	NNP
en-wikipedia-org-4107	1571	40	,	,	,
en-wikipedia-org-4107	1571	41	Lichtblau	Lichtblau	NNP
en-wikipedia-org-4107	1571	42	H	H	NNP
en-wikipedia-org-4107	1571	43	,	,	,
en-wikipedia-org-4107	1571	44	Ochoa	Ochoa	NNP
en-wikipedia-org-4107	1571	45	FY	FY	NNP
en-wikipedia-org-4107	1571	46	,	,	,
en-wikipedia-org-4107	1571	47	Branchek	Branchek	NNP
en-wikipedia-org-4107	1571	48	TA	TA	NNP
en-wikipedia-org-4107	1571	49	,	,	,
en-wikipedia-org-4107	1571	50	Gerald	Gerald	NNP
en-wikipedia-org-4107	1571	51	C	C	NNP
en-wikipedia-org-4107	1571	52	(	(	-LRB-
en-wikipedia-org-4107	1571	53	July	July	NNP
en-wikipedia-org-4107	1571	54	2001	2001	CD
en-wikipedia-org-4107	1571	55	)	)	-RRB-
en-wikipedia-org-4107	1571	56	.	.	.
en-wikipedia-org-4107	1572	1	"	"	``
en-wikipedia-org-4107	1572	2	Trace	trace	NN
en-wikipedia-org-4107	1572	3	amines	amine	NNS
en-wikipedia-org-4107	1572	4	:	:	:
en-wikipedia-org-4107	1572	5	identification	identification	NN
en-wikipedia-org-4107	1572	6	of	of	IN
en-wikipedia-org-4107	1572	7	a	a	DT
en-wikipedia-org-4107	1572	8	family	family	NN
en-wikipedia-org-4107	1572	9	of	of	IN
en-wikipedia-org-4107	1572	10	mammalian	mammalian	JJ
en-wikipedia-org-4107	1572	11	G	G	NNP
en-wikipedia-org-4107	1572	12	protein	protein	NN
en-wikipedia-org-4107	1572	13	-	-	HYPH
en-wikipedia-org-4107	1572	14	coupled	couple	VBN
en-wikipedia-org-4107	1572	15	receptors	receptor	NNS
en-wikipedia-org-4107	1572	16	"	"	''
en-wikipedia-org-4107	1572	17	.	.	.
en-wikipedia-org-4107	1573	1	Proceedings	proceeding	NNS
en-wikipedia-org-4107	1573	2	of	of	IN
en-wikipedia-org-4107	1573	3	the	the	DT
en-wikipedia-org-4107	1573	4	National	National	NNP
en-wikipedia-org-4107	1573	5	Academy	Academy	NNP
en-wikipedia-org-4107	1573	6	of	of	IN
en-wikipedia-org-4107	1573	7	Sciences	Sciences	NNPS
en-wikipedia-org-4107	1573	8	.	.	.
en-wikipedia-org-4107	1574	1	98	98	CD
en-wikipedia-org-4107	1574	2	(	(	-LRB-
en-wikipedia-org-4107	1574	3	16	16	CD
en-wikipedia-org-4107	1574	4	)	)	-RRB-
en-wikipedia-org-4107	1574	5	:	:	:
en-wikipedia-org-4107	1574	6	8966–8971	8966–8971	CD
en-wikipedia-org-4107	1574	7	.	.	.
en-wikipedia-org-4107	1575	1	Bibcode:2001PNAS	Bibcode:2001PNAS	NNPS
en-wikipedia-org-4107	1575	2	...	...	:
en-wikipedia-org-4107	1575	3	98.8966B.	98.8966b.	CD
en-wikipedia-org-4107	1576	1	doi:10.1073	doi:10.1073	NNP
en-wikipedia-org-4107	1576	2	/	/	SYM
en-wikipedia-org-4107	1576	3	pnas.151105198	pnas.151105198	NN
en-wikipedia-org-4107	1576	4	.	.	.
en-wikipedia-org-4107	1577	1	PMC	PMC	NNP
en-wikipedia-org-4107	1577	2	 	  	_SP
en-wikipedia-org-4107	1577	3	55357	55357	CD
en-wikipedia-org-4107	1577	4	.	.	.
en-wikipedia-org-4107	1578	1	PMID	PMID	NNP
en-wikipedia-org-4107	1578	2	 	  	_SP
en-wikipedia-org-4107	1578	3	11459929	11459929	CD
en-wikipedia-org-4107	1578	4	.	.	.
en-wikipedia-org-4107	1579	1	^	^	NNP
en-wikipedia-org-4107	1579	2	a	a	DT
en-wikipedia-org-4107	1579	3	b	b	NNP
en-wikipedia-org-4107	1579	4	"	"	``
en-wikipedia-org-4107	1579	5	SLC18	SLC18	NNP
en-wikipedia-org-4107	1579	6	family	family	NN
en-wikipedia-org-4107	1579	7	of	of	IN
en-wikipedia-org-4107	1579	8	vesicular	vesicular	JJ
en-wikipedia-org-4107	1579	9	amine	amine	NN
en-wikipedia-org-4107	1579	10	transporters	transporter	NNS
en-wikipedia-org-4107	1579	11	"	"	''
en-wikipedia-org-4107	1579	12	.	.	.
en-wikipedia-org-4107	1580	1	IUPHAR	IUPHAR	NNP
en-wikipedia-org-4107	1580	2	database	database	NN
en-wikipedia-org-4107	1580	3	.	.	.
en-wikipedia-org-4107	1581	1	International	International	NNP
en-wikipedia-org-4107	1581	2	Union	Union	NNP
en-wikipedia-org-4107	1581	3	of	of	IN
en-wikipedia-org-4107	1581	4	Basic	Basic	NNP
en-wikipedia-org-4107	1581	5	and	and	CC
en-wikipedia-org-4107	1581	6	Clinical	Clinical	NNP
en-wikipedia-org-4107	1581	7	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1581	8	.	.	.
en-wikipedia-org-4107	1582	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1582	2	13	13	CD
en-wikipedia-org-4107	1582	3	November	November	NNP
en-wikipedia-org-4107	1582	4	2015	2015	CD
en-wikipedia-org-4107	1582	5	.	.	.
en-wikipedia-org-4107	1583	1	^	^	NNP
en-wikipedia-org-4107	1583	2	a	a	DT
en-wikipedia-org-4107	1583	3	b	b	NN
en-wikipedia-org-4107	1583	4	c	c	NN
en-wikipedia-org-4107	1583	5	d	d	NN
en-wikipedia-org-4107	1583	6	"	"	``
en-wikipedia-org-4107	1583	7	SLC1A1	SLC1A1	NNP
en-wikipedia-org-4107	1583	8	solute	solute	NNP
en-wikipedia-org-4107	1583	9	carrier	carrier	NN
en-wikipedia-org-4107	1583	10	family	family	NN
en-wikipedia-org-4107	1583	11	1	1	CD
en-wikipedia-org-4107	1583	12	(	(	-LRB-
en-wikipedia-org-4107	1583	13	neuronal	neuronal	JJ
en-wikipedia-org-4107	1583	14	/	/	SYM
en-wikipedia-org-4107	1583	15	epithelial	epithelial	JJ
en-wikipedia-org-4107	1583	16	high	high	JJ
en-wikipedia-org-4107	1583	17	affinity	affinity	NN
en-wikipedia-org-4107	1583	18	glutamate	glutamate	NN
en-wikipedia-org-4107	1583	19	transporter	transporter	NN
en-wikipedia-org-4107	1583	20	,	,	,
en-wikipedia-org-4107	1583	21	system	system	NN
en-wikipedia-org-4107	1583	22	Xag	Xag	NNP
en-wikipedia-org-4107	1583	23	)	)	-RRB-
en-wikipedia-org-4107	1583	24	,	,	,
en-wikipedia-org-4107	1583	25	member	member	NN
en-wikipedia-org-4107	1583	26	1	1	CD
en-wikipedia-org-4107	1583	27	[	[	-LRB-
en-wikipedia-org-4107	1583	28	Homo	homo	NN
en-wikipedia-org-4107	1583	29	sapiens	sapiens	JJ
en-wikipedia-org-4107	1583	30	(	(	-LRB-
en-wikipedia-org-4107	1583	31	human	human	JJ
en-wikipedia-org-4107	1583	32	)	)	-RRB-
en-wikipedia-org-4107	1583	33	]	]	-RRB-
en-wikipedia-org-4107	1583	34	"	"	''
en-wikipedia-org-4107	1583	35	.	.	.
en-wikipedia-org-4107	1584	1	NCBI	NCBI	NNP
en-wikipedia-org-4107	1584	2	Gene	Gene	NNP
en-wikipedia-org-4107	1584	3	.	.	.
en-wikipedia-org-4107	1585	1	United	United	NNP
en-wikipedia-org-4107	1585	2	States	States	NNP
en-wikipedia-org-4107	1585	3	National	National	NNP
en-wikipedia-org-4107	1585	4	Library	Library	NNP
en-wikipedia-org-4107	1585	5	of	of	IN
en-wikipedia-org-4107	1585	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	1585	7	 	  	_SP
en-wikipedia-org-4107	1585	8	–	–	:
en-wikipedia-org-4107	1585	9	National	National	NNP
en-wikipedia-org-4107	1585	10	Center	Center	NNP
en-wikipedia-org-4107	1585	11	for	for	IN
en-wikipedia-org-4107	1585	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	1585	13	Information	Information	NNP
en-wikipedia-org-4107	1585	14	.	.	.
en-wikipedia-org-4107	1586	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1586	2	11	11	CD
en-wikipedia-org-4107	1586	3	November	November	NNP
en-wikipedia-org-4107	1586	4	2014	2014	CD
en-wikipedia-org-4107	1586	5	.	.	.
en-wikipedia-org-4107	1587	1	Amphetamine	amphetamine	NN
en-wikipedia-org-4107	1587	2	modulates	modulate	VBZ
en-wikipedia-org-4107	1587	3	excitatory	excitatory	NN
en-wikipedia-org-4107	1587	4	neurotransmission	neurotransmission	NN
en-wikipedia-org-4107	1587	5	through	through	IN
en-wikipedia-org-4107	1587	6	endocytosis	endocytosis	NN
en-wikipedia-org-4107	1587	7	of	of	IN
en-wikipedia-org-4107	1587	8	the	the	DT
en-wikipedia-org-4107	1587	9	glutamate	glutamate	JJ
en-wikipedia-org-4107	1587	10	transporter	transporter	NN
en-wikipedia-org-4107	1587	11	EAAT3	eaat3	NN
en-wikipedia-org-4107	1587	12	in	in	IN
en-wikipedia-org-4107	1587	13	dopamine	dopamine	NN
en-wikipedia-org-4107	1587	14	neurons	neuron	NNS
en-wikipedia-org-4107	1587	15	.	.	.
en-wikipedia-org-4107	1588	1	...	...	NFP
en-wikipedia-org-4107	1588	2	internalization	internalization	NN
en-wikipedia-org-4107	1588	3	of	of	IN
en-wikipedia-org-4107	1588	4	EAAT3	EAAT3	NNP
en-wikipedia-org-4107	1588	5	triggered	trigger	VBN
en-wikipedia-org-4107	1588	6	by	by	IN
en-wikipedia-org-4107	1588	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1588	8	increases	increase	VBZ
en-wikipedia-org-4107	1588	9	glutamatergic	glutamatergic	JJ
en-wikipedia-org-4107	1588	10	signaling	signaling	NN
en-wikipedia-org-4107	1588	11	and	and	CC
en-wikipedia-org-4107	1588	12	thus	thus	RB
en-wikipedia-org-4107	1588	13	contributes	contribute	VBZ
en-wikipedia-org-4107	1588	14	to	to	IN
en-wikipedia-org-4107	1588	15	the	the	DT
en-wikipedia-org-4107	1588	16	effects	effect	NNS
en-wikipedia-org-4107	1588	17	of	of	IN
en-wikipedia-org-4107	1588	18	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1588	19	on	on	IN
en-wikipedia-org-4107	1588	20	neurotransmission	neurotransmission	NN
en-wikipedia-org-4107	1588	21	.	.	.
en-wikipedia-org-4107	1589	1	^	^	NNP
en-wikipedia-org-4107	1589	2	Zhu	Zhu	NNP
en-wikipedia-org-4107	1589	3	HJ	HJ	NNP
en-wikipedia-org-4107	1589	4	,	,	,
en-wikipedia-org-4107	1589	5	Appel	Appel	NNP
en-wikipedia-org-4107	1589	6	DI	DI	NNP
en-wikipedia-org-4107	1589	7	,	,	,
en-wikipedia-org-4107	1589	8	Gründemann	Gründemann	NNP
en-wikipedia-org-4107	1589	9	D	D	NNP
en-wikipedia-org-4107	1589	10	,	,	,
en-wikipedia-org-4107	1589	11	Markowitz	Markowitz	NNP
en-wikipedia-org-4107	1589	12	JS	JS	NNP
en-wikipedia-org-4107	1589	13	(	(	-LRB-
en-wikipedia-org-4107	1589	14	July	July	NNP
en-wikipedia-org-4107	1589	15	2010	2010	CD
en-wikipedia-org-4107	1589	16	)	)	-RRB-
en-wikipedia-org-4107	1589	17	.	.	.
en-wikipedia-org-4107	1590	1	"	"	``
en-wikipedia-org-4107	1590	2	Interaction	Interaction	NNP
en-wikipedia-org-4107	1590	3	of	of	IN
en-wikipedia-org-4107	1590	4	organic	organic	NNP
en-wikipedia-org-4107	1590	5	cation	cation	NN
en-wikipedia-org-4107	1590	6	transporter	transporter	NNP
en-wikipedia-org-4107	1590	7	3	3	CD
en-wikipedia-org-4107	1590	8	(	(	-LRB-
en-wikipedia-org-4107	1590	9	SLC22A3	SLC22A3	NNP
en-wikipedia-org-4107	1590	10	)	)	-RRB-
en-wikipedia-org-4107	1590	11	and	and	CC
en-wikipedia-org-4107	1590	12	amphetamine	amphetamine	VB
en-wikipedia-org-4107	1590	13	"	"	''
en-wikipedia-org-4107	1590	14	.	.	.
en-wikipedia-org-4107	1591	1	Journal	Journal	NNP
en-wikipedia-org-4107	1591	2	of	of	IN
en-wikipedia-org-4107	1591	3	Neurochemistry	Neurochemistry	NNP
en-wikipedia-org-4107	1591	4	.	.	.
en-wikipedia-org-4107	1592	1	114	114	CD
en-wikipedia-org-4107	1592	2	(	(	-LRB-
en-wikipedia-org-4107	1592	3	1	1	CD
en-wikipedia-org-4107	1592	4	)	)	-RRB-
en-wikipedia-org-4107	1592	5	:	:	:
en-wikipedia-org-4107	1592	6	142–149	142–149	CD
en-wikipedia-org-4107	1592	7	.	.	.
en-wikipedia-org-4107	1593	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-4107	1593	2	/	/	SYM
en-wikipedia-org-4107	1593	3	j.1471	j.1471	NNP
en-wikipedia-org-4107	1593	4	-	-	HYPH
en-wikipedia-org-4107	1593	5	4159.2010.06738.x	4159.2010.06738.x	CD
en-wikipedia-org-4107	1593	6	.	.	.
en-wikipedia-org-4107	1594	1	PMC	PMC	NNP
en-wikipedia-org-4107	1594	2	 	  	_SP
en-wikipedia-org-4107	1594	3	3775896	3775896	CD
en-wikipedia-org-4107	1594	4	.	.	.
en-wikipedia-org-4107	1595	1	PMID	PMID	NNP
en-wikipedia-org-4107	1595	2	 	  	_SP
en-wikipedia-org-4107	1595	3	20402963	20402963	CD
en-wikipedia-org-4107	1595	4	.	.	.
en-wikipedia-org-4107	1596	1	^	^	NN
en-wikipedia-org-4107	1596	2	Rytting	Rytting	NNP
en-wikipedia-org-4107	1596	3	E	E	NNP
en-wikipedia-org-4107	1596	4	,	,	,
en-wikipedia-org-4107	1596	5	Audus	Audus	NNP
en-wikipedia-org-4107	1596	6	KL	KL	NNP
en-wikipedia-org-4107	1596	7	(	(	-LRB-
en-wikipedia-org-4107	1596	8	January	January	NNP
en-wikipedia-org-4107	1596	9	2005	2005	CD
en-wikipedia-org-4107	1596	10	)	)	-RRB-
en-wikipedia-org-4107	1596	11	.	.	.
en-wikipedia-org-4107	1597	1	"	"	``
en-wikipedia-org-4107	1597	2	Novel	novel	JJ
en-wikipedia-org-4107	1597	3	organic	organic	JJ
en-wikipedia-org-4107	1597	4	cation	cation	NN
en-wikipedia-org-4107	1597	5	transporter	transporter	NN
en-wikipedia-org-4107	1597	6	2-mediated	2-mediated	CD
en-wikipedia-org-4107	1597	7	carnitine	carnitine	NN
en-wikipedia-org-4107	1597	8	uptake	uptake	JJ
en-wikipedia-org-4107	1597	9	in	in	IN
en-wikipedia-org-4107	1597	10	placental	placental	JJ
en-wikipedia-org-4107	1597	11	choriocarcinoma	choriocarcinoma	NN
en-wikipedia-org-4107	1597	12	(	(	-LRB-
en-wikipedia-org-4107	1597	13	BeWo	BeWo	NNP
en-wikipedia-org-4107	1597	14	)	)	-RRB-
en-wikipedia-org-4107	1597	15	cells	cell	NNS
en-wikipedia-org-4107	1597	16	"	"	''
en-wikipedia-org-4107	1597	17	.	.	.
en-wikipedia-org-4107	1598	1	Journal	Journal	NNP
en-wikipedia-org-4107	1598	2	of	of	IN
en-wikipedia-org-4107	1598	3	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1598	4	and	and	CC
en-wikipedia-org-4107	1598	5	Experimental	Experimental	NNP
en-wikipedia-org-4107	1598	6	Therapeutics	Therapeutics	NNP
en-wikipedia-org-4107	1598	7	.	.	.
en-wikipedia-org-4107	1599	1	312	312	CD
en-wikipedia-org-4107	1599	2	(	(	-LRB-
en-wikipedia-org-4107	1599	3	1	1	CD
en-wikipedia-org-4107	1599	4	)	)	-RRB-
en-wikipedia-org-4107	1599	5	:	:	:
en-wikipedia-org-4107	1599	6	192–198	192–198	CD
en-wikipedia-org-4107	1599	7	.	.	.
en-wikipedia-org-4107	1600	1	doi:10.1124	doi:10.1124	NNP
en-wikipedia-org-4107	1600	2	/	/	SYM
en-wikipedia-org-4107	1600	3	jpet.104.072363	jpet.104.072363	NNP
en-wikipedia-org-4107	1600	4	.	.	.
en-wikipedia-org-4107	1601	1	PMID	PMID	NNP
en-wikipedia-org-4107	1601	2	 	  	_SP
en-wikipedia-org-4107	1601	3	15316089	15316089	CD
en-wikipedia-org-4107	1601	4	.	.	.
en-wikipedia-org-4107	1602	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1602	2	 	  	_SP
en-wikipedia-org-4107	1602	3	31465243	31465243	CD
en-wikipedia-org-4107	1602	4	.	.	.
en-wikipedia-org-4107	1603	1	^	^	NNP
en-wikipedia-org-4107	1603	2	Inazu	Inazu	NNP
en-wikipedia-org-4107	1603	3	M	M	NNP
en-wikipedia-org-4107	1603	4	,	,	,
en-wikipedia-org-4107	1603	5	Takeda	Takeda	NNP
en-wikipedia-org-4107	1603	6	H	H	NNP
en-wikipedia-org-4107	1603	7	,	,	,
en-wikipedia-org-4107	1603	8	Matsumiya	Matsumiya	NNP
en-wikipedia-org-4107	1603	9	T	T	NNP
en-wikipedia-org-4107	1603	10	(	(	-LRB-
en-wikipedia-org-4107	1603	11	August	August	NNP
en-wikipedia-org-4107	1603	12	2003	2003	CD
en-wikipedia-org-4107	1603	13	)	)	-RRB-
en-wikipedia-org-4107	1603	14	.	.	.
en-wikipedia-org-4107	1604	1	"	"	``
en-wikipedia-org-4107	1604	2	[	[	-LRB-
en-wikipedia-org-4107	1604	3	The	the	DT
en-wikipedia-org-4107	1604	4	role	role	NN
en-wikipedia-org-4107	1604	5	of	of	IN
en-wikipedia-org-4107	1604	6	glial	glial	JJ
en-wikipedia-org-4107	1604	7	monoamine	monoamine	NN
en-wikipedia-org-4107	1604	8	transporters	transporter	NNS
en-wikipedia-org-4107	1604	9	in	in	IN
en-wikipedia-org-4107	1604	10	the	the	DT
en-wikipedia-org-4107	1604	11	central	central	JJ
en-wikipedia-org-4107	1604	12	nervous	nervous	JJ
en-wikipedia-org-4107	1604	13	system	system	NN
en-wikipedia-org-4107	1604	14	]	]	-RRB-
en-wikipedia-org-4107	1604	15	"	"	''
en-wikipedia-org-4107	1604	16	.	.	.
en-wikipedia-org-4107	1605	1	Nihon	Nihon	NNP
en-wikipedia-org-4107	1605	2	Shinkei	Shinkei	NNP
en-wikipedia-org-4107	1605	3	Seishin	Seishin	NNP
en-wikipedia-org-4107	1605	4	Yakurigaku	Yakurigaku	NNP
en-wikipedia-org-4107	1605	5	Zasshi	Zasshi	NNP
en-wikipedia-org-4107	1605	6	(	(	-LRB-
en-wikipedia-org-4107	1605	7	in	in	IN
en-wikipedia-org-4107	1605	8	Japanese	Japanese	NNP
en-wikipedia-org-4107	1605	9	)	)	-RRB-
en-wikipedia-org-4107	1605	10	.	.	.
en-wikipedia-org-4107	1606	1	23	23	CD
en-wikipedia-org-4107	1606	2	(	(	-LRB-
en-wikipedia-org-4107	1606	3	4	4	CD
en-wikipedia-org-4107	1606	4	)	)	-RRB-
en-wikipedia-org-4107	1606	5	:	:	:
en-wikipedia-org-4107	1606	6	171–178	171–178	CD
en-wikipedia-org-4107	1606	7	.	.	.
en-wikipedia-org-4107	1607	1	PMID	PMID	NNP
en-wikipedia-org-4107	1607	2	 	  	_SP
en-wikipedia-org-4107	1607	3	13677912	13677912	CD
en-wikipedia-org-4107	1607	4	.	.	.
en-wikipedia-org-4107	1608	1	^	^	NNP
en-wikipedia-org-4107	1608	2	a	a	DT
en-wikipedia-org-4107	1608	3	b	b	NN
en-wikipedia-org-4107	1608	4	c	c	NN
en-wikipedia-org-4107	1608	5	Vicentic	Vicentic	NNP
en-wikipedia-org-4107	1608	6	A	A	NNP
en-wikipedia-org-4107	1608	7	,	,	,
en-wikipedia-org-4107	1608	8	Jones	Jones	NNP
en-wikipedia-org-4107	1608	9	DC	DC	NNP
en-wikipedia-org-4107	1608	10	(	(	-LRB-
en-wikipedia-org-4107	1608	11	February	February	NNP
en-wikipedia-org-4107	1608	12	2007	2007	CD
en-wikipedia-org-4107	1608	13	)	)	-RRB-
en-wikipedia-org-4107	1608	14	.	.	.
en-wikipedia-org-4107	1609	1	"	"	``
en-wikipedia-org-4107	1609	2	The	the	DT
en-wikipedia-org-4107	1609	3	CART	CART	NNP
en-wikipedia-org-4107	1609	4	(	(	-LRB-
en-wikipedia-org-4107	1609	5	cocaine-	cocaine-	JJ
en-wikipedia-org-4107	1609	6	and	and	CC
en-wikipedia-org-4107	1609	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1609	8	-	-	HYPH
en-wikipedia-org-4107	1609	9	regulated	regulate	VBN
en-wikipedia-org-4107	1609	10	transcript	transcript	NN
en-wikipedia-org-4107	1609	11	)	)	-RRB-
en-wikipedia-org-4107	1609	12	system	system	NN
en-wikipedia-org-4107	1609	13	in	in	IN
en-wikipedia-org-4107	1609	14	appetite	appetite	NN
en-wikipedia-org-4107	1609	15	and	and	CC
en-wikipedia-org-4107	1609	16	drug	drug	NN
en-wikipedia-org-4107	1609	17	addiction	addiction	NN
en-wikipedia-org-4107	1609	18	"	"	''
en-wikipedia-org-4107	1609	19	.	.	.
en-wikipedia-org-4107	1610	1	Journal	Journal	NNP
en-wikipedia-org-4107	1610	2	of	of	IN
en-wikipedia-org-4107	1610	3	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1610	4	and	and	CC
en-wikipedia-org-4107	1610	5	Experimental	Experimental	NNP
en-wikipedia-org-4107	1610	6	Therapeutics	Therapeutics	NNP
en-wikipedia-org-4107	1610	7	.	.	.
en-wikipedia-org-4107	1611	1	320	320	CD
en-wikipedia-org-4107	1611	2	(	(	-LRB-
en-wikipedia-org-4107	1611	3	2	2	CD
en-wikipedia-org-4107	1611	4	)	)	-RRB-
en-wikipedia-org-4107	1611	5	:	:	:
en-wikipedia-org-4107	1611	6	499–506	499–506	CD
en-wikipedia-org-4107	1611	7	.	.	.
en-wikipedia-org-4107	1612	1	doi:10.1124	doi:10.1124	NNP
en-wikipedia-org-4107	1612	2	/	/	SYM
en-wikipedia-org-4107	1612	3	jpet.105.091512	jpet.105.091512	NNP
en-wikipedia-org-4107	1612	4	.	.	.
en-wikipedia-org-4107	1613	1	PMID	PMID	NNP
en-wikipedia-org-4107	1613	2	 	  	_SP
en-wikipedia-org-4107	1613	3	16840648	16840648	CD
en-wikipedia-org-4107	1613	4	.	.	.
en-wikipedia-org-4107	1614	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1614	2	 	  	_SP
en-wikipedia-org-4107	1614	3	14212763	14212763	CD
en-wikipedia-org-4107	1614	4	.	.	.
en-wikipedia-org-4107	1615	1	The	the	DT
en-wikipedia-org-4107	1615	2	physiological	physiological	JJ
en-wikipedia-org-4107	1615	3	importance	importance	NN
en-wikipedia-org-4107	1615	4	of	of	IN
en-wikipedia-org-4107	1615	5	CART	CART	NNP
en-wikipedia-org-4107	1615	6	was	be	VBD
en-wikipedia-org-4107	1615	7	further	further	RB
en-wikipedia-org-4107	1615	8	substantiated	substantiate	VBN
en-wikipedia-org-4107	1615	9	in	in	IN
en-wikipedia-org-4107	1615	10	numerous	numerous	JJ
en-wikipedia-org-4107	1615	11	human	human	JJ
en-wikipedia-org-4107	1615	12	studies	study	NNS
en-wikipedia-org-4107	1615	13	demonstrating	demonstrate	VBG
en-wikipedia-org-4107	1615	14	a	a	DT
en-wikipedia-org-4107	1615	15	role	role	NN
en-wikipedia-org-4107	1615	16	of	of	IN
en-wikipedia-org-4107	1615	17	CART	CART	NNP
en-wikipedia-org-4107	1615	18	in	in	IN
en-wikipedia-org-4107	1615	19	both	both	CC
en-wikipedia-org-4107	1615	20	feeding	feeding	NN
en-wikipedia-org-4107	1615	21	and	and	CC
en-wikipedia-org-4107	1615	22	psychostimulant	psychostimulant	JJ
en-wikipedia-org-4107	1615	23	addiction	addiction	NN
en-wikipedia-org-4107	1615	24	.	.	.
en-wikipedia-org-4107	1616	1	...	...	NFP
en-wikipedia-org-4107	1616	2	Colocalization	colocalization	NN
en-wikipedia-org-4107	1616	3	studies	study	NNS
en-wikipedia-org-4107	1616	4	also	also	RB
en-wikipedia-org-4107	1616	5	support	support	VBP
en-wikipedia-org-4107	1616	6	a	a	DT
en-wikipedia-org-4107	1616	7	role	role	NN
en-wikipedia-org-4107	1616	8	for	for	IN
en-wikipedia-org-4107	1616	9	CART	CART	NNP
en-wikipedia-org-4107	1616	10	in	in	IN
en-wikipedia-org-4107	1616	11	the	the	DT
en-wikipedia-org-4107	1616	12	actions	action	NNS
en-wikipedia-org-4107	1616	13	of	of	IN
en-wikipedia-org-4107	1616	14	psychostimulants	psychostimulant	NNS
en-wikipedia-org-4107	1616	15	.	.	.
en-wikipedia-org-4107	1617	1	...	...	:
en-wikipedia-org-4107	1617	2	CART	CART	NNP
en-wikipedia-org-4107	1617	3	and	and	CC
en-wikipedia-org-4107	1617	4	DA	DA	NNP
en-wikipedia-org-4107	1617	5	receptor	receptor	NN
en-wikipedia-org-4107	1617	6	transcripts	transcript	NNS
en-wikipedia-org-4107	1617	7	colocalize	colocalize	NN
en-wikipedia-org-4107	1617	8	(	(	-LRB-
en-wikipedia-org-4107	1617	9	Beaudry	Beaudry	NNP
en-wikipedia-org-4107	1617	10	et	et	NNP
en-wikipedia-org-4107	1617	11	al	al	NNP
en-wikipedia-org-4107	1617	12	.	.	NNP
en-wikipedia-org-4107	1617	13	,	,	,
en-wikipedia-org-4107	1617	14	2004	2004	CD
en-wikipedia-org-4107	1617	15	)	)	-RRB-
en-wikipedia-org-4107	1617	16	.	.	.
en-wikipedia-org-4107	1618	1	Second	second	JJ
en-wikipedia-org-4107	1618	2	,	,	,
en-wikipedia-org-4107	1618	3	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	1618	4	nerve	nerve	NN
en-wikipedia-org-4107	1618	5	terminals	terminal	NNS
en-wikipedia-org-4107	1618	6	in	in	IN
en-wikipedia-org-4107	1618	7	the	the	DT
en-wikipedia-org-4107	1618	8	NAc	NAc	NNS
en-wikipedia-org-4107	1618	9	synapse	synapse	VBD
en-wikipedia-org-4107	1618	10	on	on	IN
en-wikipedia-org-4107	1618	11	CART	CART	NNP
en-wikipedia-org-4107	1618	12	-	-	HYPH
en-wikipedia-org-4107	1618	13	containing	contain	VBG
en-wikipedia-org-4107	1618	14	neurons	neuron	NNS
en-wikipedia-org-4107	1618	15	(	(	-LRB-
en-wikipedia-org-4107	1618	16	Koylu	Koylu	NNP
en-wikipedia-org-4107	1618	17	et	et	NNP
en-wikipedia-org-4107	1618	18	al	al	NNP
en-wikipedia-org-4107	1618	19	.	.	NNP
en-wikipedia-org-4107	1618	20	,	,	,
en-wikipedia-org-4107	1618	21	1999	1999	CD
en-wikipedia-org-4107	1618	22	)	)	-RRB-
en-wikipedia-org-4107	1618	23	,	,	,
en-wikipedia-org-4107	1618	24	hence	hence	RB
en-wikipedia-org-4107	1618	25	providing	provide	VBG
en-wikipedia-org-4107	1618	26	the	the	DT
en-wikipedia-org-4107	1618	27	proximity	proximity	NN
en-wikipedia-org-4107	1618	28	required	require	VBN
en-wikipedia-org-4107	1618	29	for	for	IN
en-wikipedia-org-4107	1618	30	neurotransmitter	neurotransmitter	NN
en-wikipedia-org-4107	1618	31	signaling	signaling	NN
en-wikipedia-org-4107	1618	32	.	.	.
en-wikipedia-org-4107	1619	1	These	these	DT
en-wikipedia-org-4107	1619	2	studies	study	NNS
en-wikipedia-org-4107	1619	3	suggest	suggest	VBP
en-wikipedia-org-4107	1619	4	that	that	IN
en-wikipedia-org-4107	1619	5	DA	DA	NNP
en-wikipedia-org-4107	1619	6	plays	play	VBZ
en-wikipedia-org-4107	1619	7	a	a	DT
en-wikipedia-org-4107	1619	8	role	role	NN
en-wikipedia-org-4107	1619	9	in	in	IN
en-wikipedia-org-4107	1619	10	regulating	regulate	VBG
en-wikipedia-org-4107	1619	11	CART	CART	NNP
en-wikipedia-org-4107	1619	12	gene	gene	NN
en-wikipedia-org-4107	1619	13	expression	expression	NN
en-wikipedia-org-4107	1619	14	possibly	possibly	RB
en-wikipedia-org-4107	1619	15	via	via	IN
en-wikipedia-org-4107	1619	16	the	the	DT
en-wikipedia-org-4107	1619	17	activation	activation	NN
en-wikipedia-org-4107	1619	18	of	of	IN
en-wikipedia-org-4107	1619	19	CREB	CREB	NNP
en-wikipedia-org-4107	1619	20	.	.	.
en-wikipedia-org-4107	1620	1	^	^	NNP
en-wikipedia-org-4107	1620	2	Zhang	Zhang	NNP
en-wikipedia-org-4107	1620	3	M	M	NNP
en-wikipedia-org-4107	1620	4	,	,	,
en-wikipedia-org-4107	1620	5	Han	Han	NNP
en-wikipedia-org-4107	1620	6	L	L	NNP
en-wikipedia-org-4107	1620	7	,	,	,
en-wikipedia-org-4107	1620	8	Xu	Xu	NNP
en-wikipedia-org-4107	1620	9	Y	Y	NNP
en-wikipedia-org-4107	1620	10	(	(	-LRB-
en-wikipedia-org-4107	1620	11	June	June	NNP
en-wikipedia-org-4107	1620	12	2012	2012	CD
en-wikipedia-org-4107	1620	13	)	)	-RRB-
en-wikipedia-org-4107	1620	14	.	.	.
en-wikipedia-org-4107	1621	1	"	"	``
en-wikipedia-org-4107	1621	2	Roles	Roles	NNPS
en-wikipedia-org-4107	1621	3	of	of	IN
en-wikipedia-org-4107	1621	4	cocaine-	cocaine-	NN
en-wikipedia-org-4107	1621	5	and	and	CC
en-wikipedia-org-4107	1621	6	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1621	7	-	-	HYPH
en-wikipedia-org-4107	1621	8	regulated	regulate	VBN
en-wikipedia-org-4107	1621	9	transcript	transcript	NN
en-wikipedia-org-4107	1621	10	in	in	IN
en-wikipedia-org-4107	1621	11	the	the	DT
en-wikipedia-org-4107	1621	12	central	central	JJ
en-wikipedia-org-4107	1621	13	nervous	nervous	JJ
en-wikipedia-org-4107	1621	14	system	system	NN
en-wikipedia-org-4107	1621	15	"	"	''
en-wikipedia-org-4107	1621	16	.	.	.
en-wikipedia-org-4107	1622	1	Clinical	clinical	JJ
en-wikipedia-org-4107	1622	2	and	and	CC
en-wikipedia-org-4107	1622	3	Experimental	Experimental	NNP
en-wikipedia-org-4107	1622	4	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1622	5	and	and	CC
en-wikipedia-org-4107	1622	6	Physiology	Physiology	NNP
en-wikipedia-org-4107	1622	7	.	.	.
en-wikipedia-org-4107	1623	1	39	39	CD
en-wikipedia-org-4107	1623	2	(	(	-LRB-
en-wikipedia-org-4107	1623	3	6	6	CD
en-wikipedia-org-4107	1623	4	)	)	-RRB-
en-wikipedia-org-4107	1623	5	:	:	:
en-wikipedia-org-4107	1623	6	586–592	586–592	CD
en-wikipedia-org-4107	1623	7	.	.	.
en-wikipedia-org-4107	1624	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-4107	1624	2	/	/	SYM
en-wikipedia-org-4107	1624	3	j.1440	j.1440	NNP
en-wikipedia-org-4107	1624	4	-	-	HYPH
en-wikipedia-org-4107	1624	5	1681.2011.05642.x	1681.2011.05642.x	CD
en-wikipedia-org-4107	1624	6	.	.	.
en-wikipedia-org-4107	1625	1	PMID	PMID	NNP
en-wikipedia-org-4107	1625	2	 	  	_SP
en-wikipedia-org-4107	1625	3	22077697	22077697	CD
en-wikipedia-org-4107	1625	4	.	.	.
en-wikipedia-org-4107	1626	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1626	2	 	  	_SP
en-wikipedia-org-4107	1626	3	25134612	25134612	CD
en-wikipedia-org-4107	1626	4	.	.	.
en-wikipedia-org-4107	1627	1	Recently	recently	RB
en-wikipedia-org-4107	1627	2	,	,	,
en-wikipedia-org-4107	1627	3	it	-PRON-	PRP
en-wikipedia-org-4107	1627	4	was	be	VBD
en-wikipedia-org-4107	1627	5	demonstrated	demonstrate	VBN
en-wikipedia-org-4107	1627	6	that	that	IN
en-wikipedia-org-4107	1627	7	CART	CART	NNP
en-wikipedia-org-4107	1627	8	,	,	,
en-wikipedia-org-4107	1627	9	as	as	IN
en-wikipedia-org-4107	1627	10	a	a	DT
en-wikipedia-org-4107	1627	11	neurotrophic	neurotrophic	JJ
en-wikipedia-org-4107	1627	12	peptide	peptide	NN
en-wikipedia-org-4107	1627	13	,	,	,
en-wikipedia-org-4107	1627	14	had	have	VBD
en-wikipedia-org-4107	1627	15	a	a	DT
en-wikipedia-org-4107	1627	16	cerebroprotective	cerebroprotective	NN
en-wikipedia-org-4107	1627	17	against	against	IN
en-wikipedia-org-4107	1627	18	focal	focal	JJ
en-wikipedia-org-4107	1627	19	ischaemic	ischaemic	JJ
en-wikipedia-org-4107	1627	20	stroke	stroke	NN
en-wikipedia-org-4107	1627	21	and	and	CC
en-wikipedia-org-4107	1627	22	inhibited	inhibit	VBD
en-wikipedia-org-4107	1627	23	the	the	DT
en-wikipedia-org-4107	1627	24	neurotoxicity	neurotoxicity	NN
en-wikipedia-org-4107	1627	25	of	of	IN
en-wikipedia-org-4107	1627	26	β	β	NNP
en-wikipedia-org-4107	1627	27	-	-	HYPH
en-wikipedia-org-4107	1627	28	amyloid	amyloid	NN
en-wikipedia-org-4107	1627	29	protein	protein	NN
en-wikipedia-org-4107	1627	30	,	,	,
en-wikipedia-org-4107	1627	31	which	which	WDT
en-wikipedia-org-4107	1627	32	focused	focus	VBD
en-wikipedia-org-4107	1627	33	attention	attention	NN
en-wikipedia-org-4107	1627	34	on	on	IN
en-wikipedia-org-4107	1627	35	the	the	DT
en-wikipedia-org-4107	1627	36	role	role	NN
en-wikipedia-org-4107	1627	37	of	of	IN
en-wikipedia-org-4107	1627	38	CART	CART	NNP
en-wikipedia-org-4107	1627	39	in	in	IN
en-wikipedia-org-4107	1627	40	the	the	DT
en-wikipedia-org-4107	1627	41	central	central	JJ
en-wikipedia-org-4107	1627	42	nervous	nervous	JJ
en-wikipedia-org-4107	1627	43	system	system	NN
en-wikipedia-org-4107	1627	44	(	(	-LRB-
en-wikipedia-org-4107	1627	45	CNS	cns	NN
en-wikipedia-org-4107	1627	46	)	)	-RRB-
en-wikipedia-org-4107	1627	47	and	and	CC
en-wikipedia-org-4107	1627	48	neurological	neurological	JJ
en-wikipedia-org-4107	1627	49	diseases	disease	NNS
en-wikipedia-org-4107	1627	50	.	.	.
en-wikipedia-org-4107	1628	1	...	...	NFP
en-wikipedia-org-4107	1629	1	The	the	DT
en-wikipedia-org-4107	1629	2	literature	literature	NN
en-wikipedia-org-4107	1629	3	indicates	indicate	VBZ
en-wikipedia-org-4107	1629	4	that	that	IN
en-wikipedia-org-4107	1629	5	there	there	EX
en-wikipedia-org-4107	1629	6	are	be	VBP
en-wikipedia-org-4107	1629	7	many	many	JJ
en-wikipedia-org-4107	1629	8	factors	factor	NNS
en-wikipedia-org-4107	1629	9	,	,	,
en-wikipedia-org-4107	1629	10	such	such	JJ
en-wikipedia-org-4107	1629	11	as	as	IN
en-wikipedia-org-4107	1629	12	regulation	regulation	NN
en-wikipedia-org-4107	1629	13	of	of	IN
en-wikipedia-org-4107	1629	14	the	the	DT
en-wikipedia-org-4107	1629	15	immunological	immunological	JJ
en-wikipedia-org-4107	1629	16	system	system	NN
en-wikipedia-org-4107	1629	17	and	and	CC
en-wikipedia-org-4107	1629	18	protection	protection	NN
en-wikipedia-org-4107	1629	19	against	against	IN
en-wikipedia-org-4107	1629	20	energy	energy	NN
en-wikipedia-org-4107	1629	21	failure	failure	NN
en-wikipedia-org-4107	1629	22	,	,	,
en-wikipedia-org-4107	1629	23	that	that	WDT
en-wikipedia-org-4107	1629	24	may	may	MD
en-wikipedia-org-4107	1629	25	be	be	VB
en-wikipedia-org-4107	1629	26	involved	involve	VBN
en-wikipedia-org-4107	1629	27	in	in	IN
en-wikipedia-org-4107	1629	28	the	the	DT
en-wikipedia-org-4107	1629	29	cerebroprotection	cerebroprotection	NN
en-wikipedia-org-4107	1629	30	afforded	afford	VBN
en-wikipedia-org-4107	1629	31	by	by	IN
en-wikipedia-org-4107	1629	32	CART	CART	NNP
en-wikipedia-org-4107	1629	33	^	^	NN
en-wikipedia-org-4107	1629	34	a	a	DT
en-wikipedia-org-4107	1629	35	b	b	NN
en-wikipedia-org-4107	1629	36	Rogge	Rogge	NNP
en-wikipedia-org-4107	1629	37	G	G	NNP
en-wikipedia-org-4107	1629	38	,	,	,
en-wikipedia-org-4107	1629	39	Jones	Jones	NNP
en-wikipedia-org-4107	1629	40	D	D	NNP
en-wikipedia-org-4107	1629	41	,	,	,
en-wikipedia-org-4107	1629	42	Hubert	Hubert	NNP
en-wikipedia-org-4107	1629	43	GW	GW	NNP
en-wikipedia-org-4107	1629	44	,	,	,
en-wikipedia-org-4107	1629	45	Lin	Lin	NNP
en-wikipedia-org-4107	1629	46	Y	Y	NNP
en-wikipedia-org-4107	1629	47	,	,	,
en-wikipedia-org-4107	1629	48	Kuhar	Kuhar	NNP
en-wikipedia-org-4107	1629	49	MJ	MJ	NNP
en-wikipedia-org-4107	1629	50	(	(	-LRB-
en-wikipedia-org-4107	1629	51	October	October	NNP
en-wikipedia-org-4107	1629	52	2008	2008	CD
en-wikipedia-org-4107	1629	53	)	)	-RRB-
en-wikipedia-org-4107	1629	54	.	.	.
en-wikipedia-org-4107	1630	1	"	"	``
en-wikipedia-org-4107	1630	2	CART	cart	NN
en-wikipedia-org-4107	1630	3	peptides	peptide	NNS
en-wikipedia-org-4107	1630	4	:	:	:
en-wikipedia-org-4107	1630	5	regulators	regulator	NNS
en-wikipedia-org-4107	1630	6	of	of	IN
en-wikipedia-org-4107	1630	7	body	body	NN
en-wikipedia-org-4107	1630	8	weight	weight	NN
en-wikipedia-org-4107	1630	9	,	,	,
en-wikipedia-org-4107	1630	10	reward	reward	NN
en-wikipedia-org-4107	1630	11	and	and	CC
en-wikipedia-org-4107	1630	12	other	other	JJ
en-wikipedia-org-4107	1630	13	functions	function	NNS
en-wikipedia-org-4107	1630	14	"	"	''
en-wikipedia-org-4107	1630	15	.	.	.
en-wikipedia-org-4107	1631	1	Nature	Nature	NNP
en-wikipedia-org-4107	1631	2	Reviews	review	NNS
en-wikipedia-org-4107	1631	3	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1631	4	.	.	.
en-wikipedia-org-4107	1632	1	9	9	CD
en-wikipedia-org-4107	1632	2	(	(	-LRB-
en-wikipedia-org-4107	1632	3	10	10	CD
en-wikipedia-org-4107	1632	4	)	)	-RRB-
en-wikipedia-org-4107	1632	5	:	:	:
en-wikipedia-org-4107	1632	6	747–758	747–758	CD
en-wikipedia-org-4107	1632	7	.	.	.
en-wikipedia-org-4107	1633	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-4107	1633	2	/	/	SYM
en-wikipedia-org-4107	1633	3	nrn2493	nrn2493	NNP
en-wikipedia-org-4107	1633	4	.	.	.
en-wikipedia-org-4107	1634	1	PMC	PMC	NNP
en-wikipedia-org-4107	1634	2	 	  	_SP
en-wikipedia-org-4107	1634	3	4418456	4418456	CD
en-wikipedia-org-4107	1634	4	.	.	.
en-wikipedia-org-4107	1635	1	PMID	PMID	NNP
en-wikipedia-org-4107	1635	2	 	  	_SP
en-wikipedia-org-4107	1635	3	18802445	18802445	CD
en-wikipedia-org-4107	1635	4	.	.	.
en-wikipedia-org-4107	1636	1	Several	several	JJ
en-wikipedia-org-4107	1636	2	studies	study	NNS
en-wikipedia-org-4107	1636	3	on	on	IN
en-wikipedia-org-4107	1636	4	CART	CART	NNP
en-wikipedia-org-4107	1636	5	(	(	-LRB-
en-wikipedia-org-4107	1636	6	cocaine-	cocaine-	JJ
en-wikipedia-org-4107	1636	7	and	and	CC
en-wikipedia-org-4107	1636	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1636	9	-	-	HYPH
en-wikipedia-org-4107	1636	10	regulated	regulate	VBN
en-wikipedia-org-4107	1636	11	transcript)-peptide	transcript)-peptide	NNP
en-wikipedia-org-4107	1636	12	-	-	HYPH
en-wikipedia-org-4107	1636	13	induced	induce	VBN
en-wikipedia-org-4107	1636	14	cell	cell	NN
en-wikipedia-org-4107	1636	15	signalling	signalling	NN
en-wikipedia-org-4107	1636	16	have	have	VBP
en-wikipedia-org-4107	1636	17	demonstrated	demonstrate	VBN
en-wikipedia-org-4107	1636	18	that	that	IN
en-wikipedia-org-4107	1636	19	CART	CART	NNP
en-wikipedia-org-4107	1636	20	peptides	peptide	NNS
en-wikipedia-org-4107	1636	21	activate	activate	VBP
en-wikipedia-org-4107	1636	22	at	at	IN
en-wikipedia-org-4107	1636	23	least	least	RBS
en-wikipedia-org-4107	1636	24	three	three	CD
en-wikipedia-org-4107	1636	25	signalling	signalling	NN
en-wikipedia-org-4107	1636	26	mechanisms	mechanism	NNS
en-wikipedia-org-4107	1636	27	.	.	.
en-wikipedia-org-4107	1637	1	First	first	RB
en-wikipedia-org-4107	1637	2	,	,	,
en-wikipedia-org-4107	1637	3	CART	CART	NNP
en-wikipedia-org-4107	1637	4	55–102	55–102	CD
en-wikipedia-org-4107	1637	5	inhibited	inhibit	VBD
en-wikipedia-org-4107	1637	6	voltage	voltage	NN
en-wikipedia-org-4107	1637	7	-	-	HYPH
en-wikipedia-org-4107	1637	8	gated	gate	VBN
en-wikipedia-org-4107	1637	9	L	l	NN
en-wikipedia-org-4107	1637	10	-	-	HYPH
en-wikipedia-org-4107	1637	11	type	type	NN
en-wikipedia-org-4107	1637	12	Ca2	ca2	NN
en-wikipedia-org-4107	1637	13	+	+	CC
en-wikipedia-org-4107	1637	14	channels	channel	NNS
en-wikipedia-org-4107	1637	15	 	  	_SP
en-wikipedia-org-4107	1637	16	...	...	:
en-wikipedia-org-4107	1637	17	^	^	NN
en-wikipedia-org-4107	1637	18	Lin	Lin	NNP
en-wikipedia-org-4107	1637	19	Y	Y	NNP
en-wikipedia-org-4107	1637	20	,	,	,
en-wikipedia-org-4107	1637	21	Hall	Hall	NNP
en-wikipedia-org-4107	1637	22	RA	RA	NNP
en-wikipedia-org-4107	1637	23	,	,	,
en-wikipedia-org-4107	1637	24	Kuhar	Kuhar	NNP
en-wikipedia-org-4107	1637	25	MJ	MJ	NNP
en-wikipedia-org-4107	1637	26	(	(	-LRB-
en-wikipedia-org-4107	1637	27	October	October	NNP
en-wikipedia-org-4107	1637	28	2011	2011	CD
en-wikipedia-org-4107	1637	29	)	)	-RRB-
en-wikipedia-org-4107	1637	30	.	.	.
en-wikipedia-org-4107	1638	1	"	"	``
en-wikipedia-org-4107	1638	2	CART	cart	JJ
en-wikipedia-org-4107	1638	3	peptide	peptide	NN
en-wikipedia-org-4107	1638	4	stimulation	stimulation	NN
en-wikipedia-org-4107	1638	5	of	of	IN
en-wikipedia-org-4107	1638	6	G	g	NN
en-wikipedia-org-4107	1638	7	protein	protein	NN
en-wikipedia-org-4107	1638	8	-	-	HYPH
en-wikipedia-org-4107	1638	9	mediated	mediate	VBN
en-wikipedia-org-4107	1638	10	signaling	signal	VBG
en-wikipedia-org-4107	1638	11	in	in	IN
en-wikipedia-org-4107	1638	12	differentiated	differentiated	JJ
en-wikipedia-org-4107	1638	13	PC12	pc12	JJ
en-wikipedia-org-4107	1638	14	cells	cell	NNS
en-wikipedia-org-4107	1638	15	:	:	:
en-wikipedia-org-4107	1638	16	identification	identification	NN
en-wikipedia-org-4107	1638	17	of	of	IN
en-wikipedia-org-4107	1638	18	PACAP	PACAP	NNP
en-wikipedia-org-4107	1638	19	6–38	6–38	NNP
en-wikipedia-org-4107	1638	20	as	as	IN
en-wikipedia-org-4107	1638	21	a	a	DT
en-wikipedia-org-4107	1638	22	CART	CART	NNP
en-wikipedia-org-4107	1638	23	receptor	receptor	NN
en-wikipedia-org-4107	1638	24	antagonist	antagonist	NN
en-wikipedia-org-4107	1638	25	"	"	''
en-wikipedia-org-4107	1638	26	.	.	.
en-wikipedia-org-4107	1639	1	Neuropeptides	neuropeptide	NNS
en-wikipedia-org-4107	1639	2	.	.	.
en-wikipedia-org-4107	1640	1	45	45	CD
en-wikipedia-org-4107	1640	2	(	(	-LRB-
en-wikipedia-org-4107	1640	3	5	5	CD
en-wikipedia-org-4107	1640	4	)	)	-RRB-
en-wikipedia-org-4107	1640	5	:	:	:
en-wikipedia-org-4107	1640	6	351–358	351–358	CD
en-wikipedia-org-4107	1640	7	.	.	.
en-wikipedia-org-4107	1641	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1641	2	/	/	SYM
en-wikipedia-org-4107	1641	3	j.npep.2011.07.006	j.npep.2011.07.006	NN
en-wikipedia-org-4107	1641	4	.	.	.
en-wikipedia-org-4107	1642	1	PMC	PMC	NNP
en-wikipedia-org-4107	1642	2	 	  	_SP
en-wikipedia-org-4107	1642	3	3170513	3170513	CD
en-wikipedia-org-4107	1642	4	.	.	.
en-wikipedia-org-4107	1643	1	PMID	PMID	NNP
en-wikipedia-org-4107	1643	2	 	  	_SP
en-wikipedia-org-4107	1643	3	21855138	21855138	CD
en-wikipedia-org-4107	1643	4	.	.	.
en-wikipedia-org-4107	1644	1	^	^	FW
en-wikipedia-org-4107	1644	2	"	"	``
en-wikipedia-org-4107	1644	3	Monoamine	Monoamine	NNP
en-wikipedia-org-4107	1644	4	oxidase	oxidase	NN
en-wikipedia-org-4107	1644	5	(	(	-LRB-
en-wikipedia-org-4107	1644	6	Homo	homo	NN
en-wikipedia-org-4107	1644	7	sapiens	sapien	VBZ
en-wikipedia-org-4107	1644	8	)	)	-RRB-
en-wikipedia-org-4107	1644	9	"	"	''
en-wikipedia-org-4107	1644	10	.	.	.
en-wikipedia-org-4107	1645	1	BRENDA	BRENDA	NNP
en-wikipedia-org-4107	1645	2	.	.	.
en-wikipedia-org-4107	1646	1	Technische	Technische	NNP
en-wikipedia-org-4107	1646	2	Universität	Universität	NNP
en-wikipedia-org-4107	1646	3	Braunschweig	Braunschweig	NNP
en-wikipedia-org-4107	1646	4	.	.	.
en-wikipedia-org-4107	1647	1	1	1	CD
en-wikipedia-org-4107	1647	2	January	January	NNP
en-wikipedia-org-4107	1647	3	2014	2014	CD
en-wikipedia-org-4107	1647	4	.	.	.
en-wikipedia-org-4107	1648	1	Retrieved	retrieved	JJ
en-wikipedia-org-4107	1648	2	4	4	CD
en-wikipedia-org-4107	1648	3	May	May	NNP
en-wikipedia-org-4107	1648	4	2014	2014	CD
en-wikipedia-org-4107	1648	5	.	.	.
en-wikipedia-org-4107	1649	1	^	^	NNP
en-wikipedia-org-4107	1649	2	a	a	DT
en-wikipedia-org-4107	1649	3	b	b	NN
en-wikipedia-org-4107	1649	4	c	c	NN
en-wikipedia-org-4107	1649	5	"	"	``
en-wikipedia-org-4107	1649	6	Targets	target	NNS
en-wikipedia-org-4107	1649	7	"	"	''
en-wikipedia-org-4107	1649	8	.	.	.
en-wikipedia-org-4107	1650	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1650	2	.	.	.
en-wikipedia-org-4107	1651	1	T3DB	T3DB	NNP
en-wikipedia-org-4107	1651	2	.	.	.
en-wikipedia-org-4107	1652	1	University	University	NNP
en-wikipedia-org-4107	1652	2	of	of	IN
en-wikipedia-org-4107	1652	3	Alberta	Alberta	NNP
en-wikipedia-org-4107	1652	4	.	.	.
en-wikipedia-org-4107	1653	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1653	2	24	24	CD
en-wikipedia-org-4107	1653	3	February	February	NNP
en-wikipedia-org-4107	1653	4	2015	2015	CD
en-wikipedia-org-4107	1653	5	.	.	.
en-wikipedia-org-4107	1654	1	^	^	NNP
en-wikipedia-org-4107	1654	2	a	a	DT
en-wikipedia-org-4107	1654	3	b	b	NN
en-wikipedia-org-4107	1654	4	Toll	Toll	NNP
en-wikipedia-org-4107	1654	5	L	L	NNP
en-wikipedia-org-4107	1654	6	,	,	,
en-wikipedia-org-4107	1654	7	Berzetei	Berzetei	NNP
en-wikipedia-org-4107	1654	8	-	-	HYPH
en-wikipedia-org-4107	1654	9	Gurske	Gurske	NNP
en-wikipedia-org-4107	1654	10	IP	IP	NNP
en-wikipedia-org-4107	1654	11	,	,	,
en-wikipedia-org-4107	1654	12	Polgar	Polgar	NNP
en-wikipedia-org-4107	1654	13	WE	WE	NNP
en-wikipedia-org-4107	1654	14	,	,	,
en-wikipedia-org-4107	1654	15	Brandt	Brandt	NNP
en-wikipedia-org-4107	1654	16	SR	SR	NNP
en-wikipedia-org-4107	1654	17	,	,	,
en-wikipedia-org-4107	1654	18	Adapa	Adapa	NNP
en-wikipedia-org-4107	1654	19	ID	ID	NNP
en-wikipedia-org-4107	1654	20	,	,	,
en-wikipedia-org-4107	1654	21	Rodriguez	Rodriguez	NNP
en-wikipedia-org-4107	1654	22	L	L	NNP
en-wikipedia-org-4107	1654	23	,	,	,
en-wikipedia-org-4107	1654	24	Schwartz	Schwartz	NNP
en-wikipedia-org-4107	1654	25	RW	RW	NNP
en-wikipedia-org-4107	1654	26	,	,	,
en-wikipedia-org-4107	1654	27	Haggart	Haggart	NNP
en-wikipedia-org-4107	1654	28	D	D	NNP
en-wikipedia-org-4107	1654	29	,	,	,
en-wikipedia-org-4107	1654	30	O'Brien	O'Brien	NNP
en-wikipedia-org-4107	1654	31	A	A	NNP
en-wikipedia-org-4107	1654	32	,	,	,
en-wikipedia-org-4107	1654	33	White	White	NNP
en-wikipedia-org-4107	1654	34	A	A	NNP
en-wikipedia-org-4107	1654	35	,	,	,
en-wikipedia-org-4107	1654	36	Kennedy	Kennedy	NNP
en-wikipedia-org-4107	1654	37	JM	JM	NNP
en-wikipedia-org-4107	1654	38	,	,	,
en-wikipedia-org-4107	1654	39	Craymer	Craymer	NNP
en-wikipedia-org-4107	1654	40	K	K	NNP
en-wikipedia-org-4107	1654	41	,	,	,
en-wikipedia-org-4107	1654	42	Farrington	Farrington	NNP
en-wikipedia-org-4107	1654	43	L	L	NNP
en-wikipedia-org-4107	1654	44	,	,	,
en-wikipedia-org-4107	1654	45	Auh	Auh	NNP
en-wikipedia-org-4107	1654	46	JS	JS	NNP
en-wikipedia-org-4107	1654	47	(	(	-LRB-
en-wikipedia-org-4107	1654	48	March	March	NNP
en-wikipedia-org-4107	1654	49	1998	1998	CD
en-wikipedia-org-4107	1654	50	)	)	-RRB-
en-wikipedia-org-4107	1654	51	.	.	.
en-wikipedia-org-4107	1655	1	"	"	``
en-wikipedia-org-4107	1655	2	Standard	standard	JJ
en-wikipedia-org-4107	1655	3	binding	binding	NN
en-wikipedia-org-4107	1655	4	and	and	CC
en-wikipedia-org-4107	1655	5	functional	functional	JJ
en-wikipedia-org-4107	1655	6	assays	assay	NNS
en-wikipedia-org-4107	1655	7	related	relate	VBN
en-wikipedia-org-4107	1655	8	to	to	IN
en-wikipedia-org-4107	1655	9	medications	medication	NNS
en-wikipedia-org-4107	1655	10	development	development	NNP
en-wikipedia-org-4107	1655	11	division	division	NN
en-wikipedia-org-4107	1655	12	testing	testing	NN
en-wikipedia-org-4107	1655	13	for	for	IN
en-wikipedia-org-4107	1655	14	potential	potential	JJ
en-wikipedia-org-4107	1655	15	cocaine	cocaine	NN
en-wikipedia-org-4107	1655	16	and	and	CC
en-wikipedia-org-4107	1655	17	opiate	opiate	VB
en-wikipedia-org-4107	1655	18	narcotic	narcotic	JJ
en-wikipedia-org-4107	1655	19	treatment	treatment	NN
en-wikipedia-org-4107	1655	20	medications	medication	NNS
en-wikipedia-org-4107	1655	21	"	"	''
en-wikipedia-org-4107	1655	22	.	.	.
en-wikipedia-org-4107	1656	1	NIDA	NIDA	NNP
en-wikipedia-org-4107	1656	2	Research	Research	NNP
en-wikipedia-org-4107	1656	3	Monograph	Monograph	NNP
en-wikipedia-org-4107	1656	4	.	.	.
en-wikipedia-org-4107	1657	1	178	178	CD
en-wikipedia-org-4107	1657	2	:	:	:
en-wikipedia-org-4107	1657	3	440–466	440–466	CD
en-wikipedia-org-4107	1657	4	.	.	.
en-wikipedia-org-4107	1658	1	PMID	PMID	NNP
en-wikipedia-org-4107	1658	2	 	  	_SP
en-wikipedia-org-4107	1658	3	9686407	9686407	CD
en-wikipedia-org-4107	1658	4	.	.	.
en-wikipedia-org-4107	1659	1	^	^	NNP
en-wikipedia-org-4107	1659	2	a	a	DT
en-wikipedia-org-4107	1659	3	b	b	NN
en-wikipedia-org-4107	1659	4	Finnema	Finnema	NNP
en-wikipedia-org-4107	1659	5	SJ	SJ	NNP
en-wikipedia-org-4107	1659	6	,	,	,
en-wikipedia-org-4107	1659	7	Scheinin	Scheinin	NNP
en-wikipedia-org-4107	1659	8	M	M	NNP
en-wikipedia-org-4107	1659	9	,	,	,
en-wikipedia-org-4107	1659	10	Shahid	Shahid	NNP
en-wikipedia-org-4107	1659	11	M	M	NNP
en-wikipedia-org-4107	1659	12	,	,	,
en-wikipedia-org-4107	1659	13	Lehto	Lehto	NNP
en-wikipedia-org-4107	1659	14	J	J	NNP
en-wikipedia-org-4107	1659	15	,	,	,
en-wikipedia-org-4107	1659	16	Borroni	Borroni	NNP
en-wikipedia-org-4107	1659	17	E	E	NNP
en-wikipedia-org-4107	1659	18	,	,	,
en-wikipedia-org-4107	1659	19	Bang	Bang	NNP
en-wikipedia-org-4107	1659	20	-	-	HYPH
en-wikipedia-org-4107	1659	21	Andersen	Andersen	NNP
en-wikipedia-org-4107	1659	22	B	B	NNP
en-wikipedia-org-4107	1659	23	,	,	,
en-wikipedia-org-4107	1659	24	Sallinen	Sallinen	NNP
en-wikipedia-org-4107	1659	25	J	J	NNP
en-wikipedia-org-4107	1659	26	,	,	,
en-wikipedia-org-4107	1659	27	Wong	Wong	NNP
en-wikipedia-org-4107	1659	28	E	E	NNP
en-wikipedia-org-4107	1659	29	,	,	,
en-wikipedia-org-4107	1659	30	Farde	Farde	NNP
en-wikipedia-org-4107	1659	31	L	L	NNP
en-wikipedia-org-4107	1659	32	,	,	,
en-wikipedia-org-4107	1659	33	Halldin	Halldin	NNP
en-wikipedia-org-4107	1659	34	C	C	NNP
en-wikipedia-org-4107	1659	35	,	,	,
en-wikipedia-org-4107	1659	36	Grimwood	Grimwood	NNP
en-wikipedia-org-4107	1659	37	S	S	NNP
en-wikipedia-org-4107	1659	38	(	(	-LRB-
en-wikipedia-org-4107	1659	39	November	November	NNP
en-wikipedia-org-4107	1659	40	2015	2015	CD
en-wikipedia-org-4107	1659	41	)	)	-RRB-
en-wikipedia-org-4107	1659	42	.	.	.
en-wikipedia-org-4107	1660	1	"	"	``
en-wikipedia-org-4107	1660	2	Application	application	NN
en-wikipedia-org-4107	1660	3	of	of	IN
en-wikipedia-org-4107	1660	4	cross	cross	NN
en-wikipedia-org-4107	1660	5	-	-	NN
en-wikipedia-org-4107	1660	6	species	species	JJ
en-wikipedia-org-4107	1660	7	PET	PET	NNP
en-wikipedia-org-4107	1660	8	imaging	image	VBG
en-wikipedia-org-4107	1660	9	to	to	TO
en-wikipedia-org-4107	1660	10	assess	assess	VB
en-wikipedia-org-4107	1660	11	neurotransmitter	neurotransmitter	NN
en-wikipedia-org-4107	1660	12	release	release	NN
en-wikipedia-org-4107	1660	13	in	in	IN
en-wikipedia-org-4107	1660	14	brain	brain	NN
en-wikipedia-org-4107	1660	15	"	"	''
en-wikipedia-org-4107	1660	16	.	.	.
en-wikipedia-org-4107	1661	1	Psychopharmacology	psychopharmacology	NN
en-wikipedia-org-4107	1661	2	.	.	.
en-wikipedia-org-4107	1662	1	232	232	CD
en-wikipedia-org-4107	1662	2	(	(	-LRB-
en-wikipedia-org-4107	1662	3	21–22	21–22	CD
en-wikipedia-org-4107	1662	4	)	)	-RRB-
en-wikipedia-org-4107	1662	5	:	:	:
en-wikipedia-org-4107	1662	6	4129–4157	4129–4157	CD
en-wikipedia-org-4107	1662	7	.	.	.
en-wikipedia-org-4107	1663	1	doi:10.1007	doi:10.1007	VB
en-wikipedia-org-4107	1663	2	/	/	SYM
en-wikipedia-org-4107	1663	3	s00213	s00213	NNP
en-wikipedia-org-4107	1663	4	-	-	HYPH
en-wikipedia-org-4107	1663	5	015	015	CD
en-wikipedia-org-4107	1663	6	-	-	HYPH
en-wikipedia-org-4107	1663	7	3938	3938	CD
en-wikipedia-org-4107	1663	8	-	-	SYM
en-wikipedia-org-4107	1663	9	6	6	CD
en-wikipedia-org-4107	1663	10	.	.	.
en-wikipedia-org-4107	1664	1	PMC	PMC	NNP
en-wikipedia-org-4107	1664	2	 	  	_SP
en-wikipedia-org-4107	1664	3	4600473	4600473	CD
en-wikipedia-org-4107	1664	4	.	.	.
en-wikipedia-org-4107	1665	1	PMID	PMID	NNP
en-wikipedia-org-4107	1665	2	 	  	_SP
en-wikipedia-org-4107	1665	3	25921033	25921033	CD
en-wikipedia-org-4107	1665	4	.	.	.
en-wikipedia-org-4107	1666	1	More	more	RBR
en-wikipedia-org-4107	1666	2	recently	recently	RB
en-wikipedia-org-4107	1666	3	,	,	,
en-wikipedia-org-4107	1666	4	Colasanti	Colasanti	NNP
en-wikipedia-org-4107	1666	5	and	and	CC
en-wikipedia-org-4107	1666	6	colleagues	colleague	NNS
en-wikipedia-org-4107	1666	7	reported	report	VBD
en-wikipedia-org-4107	1666	8	that	that	IN
en-wikipedia-org-4107	1666	9	a	a	DT
en-wikipedia-org-4107	1666	10	pharmacologically	pharmacologically	RB
en-wikipedia-org-4107	1666	11	induced	induce	VBN
en-wikipedia-org-4107	1666	12	elevation	elevation	NN
en-wikipedia-org-4107	1666	13	in	in	IN
en-wikipedia-org-4107	1666	14	endogenous	endogenous	JJ
en-wikipedia-org-4107	1666	15	opioid	opioid	NN
en-wikipedia-org-4107	1666	16	release	release	NN
en-wikipedia-org-4107	1666	17	reduced	reduce	VBN
en-wikipedia-org-4107	1666	18	[	[	-LRB-
en-wikipedia-org-4107	1666	19	11C]carfentanil	11c]carfentanil	CD
en-wikipedia-org-4107	1666	20	binding	bind	VBG
en-wikipedia-org-4107	1666	21	in	in	IN
en-wikipedia-org-4107	1666	22	several	several	JJ
en-wikipedia-org-4107	1666	23	regions	region	NNS
en-wikipedia-org-4107	1666	24	of	of	IN
en-wikipedia-org-4107	1666	25	the	the	DT
en-wikipedia-org-4107	1666	26	human	human	JJ
en-wikipedia-org-4107	1666	27	brain	brain	NN
en-wikipedia-org-4107	1666	28	,	,	,
en-wikipedia-org-4107	1666	29	including	include	VBG
en-wikipedia-org-4107	1666	30	the	the	DT
en-wikipedia-org-4107	1666	31	basal	basal	NNP
en-wikipedia-org-4107	1666	32	ganglia	ganglia	NNP
en-wikipedia-org-4107	1666	33	,	,	,
en-wikipedia-org-4107	1666	34	frontal	frontal	JJ
en-wikipedia-org-4107	1666	35	cortex	cortex	NNP
en-wikipedia-org-4107	1666	36	,	,	,
en-wikipedia-org-4107	1666	37	and	and	CC
en-wikipedia-org-4107	1666	38	thalamus	thalamus	NNP
en-wikipedia-org-4107	1666	39	(	(	-LRB-
en-wikipedia-org-4107	1666	40	Colasanti	Colasanti	NNP
en-wikipedia-org-4107	1666	41	et	et	FW
en-wikipedia-org-4107	1666	42	al	al	NNP
en-wikipedia-org-4107	1666	43	.	.	.
en-wikipedia-org-4107	1667	1	2012	2012	CD
en-wikipedia-org-4107	1667	2	)	)	-RRB-
en-wikipedia-org-4107	1667	3	.	.	.
en-wikipedia-org-4107	1668	1	Oral	oral	JJ
en-wikipedia-org-4107	1668	2	administration	administration	NN
en-wikipedia-org-4107	1668	3	of	of	IN
en-wikipedia-org-4107	1668	4	d	d	NNP
en-wikipedia-org-4107	1668	5	-	-	HYPH
en-wikipedia-org-4107	1668	6	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1668	7	,	,	,
en-wikipedia-org-4107	1668	8	0.5	0.5	CD
en-wikipedia-org-4107	1668	9	 	  	_SP
en-wikipedia-org-4107	1668	10	mg	mg	NNP
en-wikipedia-org-4107	1668	11	/	/	SYM
en-wikipedia-org-4107	1668	12	kg	kg	NNP
en-wikipedia-org-4107	1668	13	,	,	,
en-wikipedia-org-4107	1668	14	3	3	CD
en-wikipedia-org-4107	1668	15	 	  	_SP
en-wikipedia-org-4107	1668	16	h	h	NN
en-wikipedia-org-4107	1668	17	before	before	IN
en-wikipedia-org-4107	1668	18	[	[	-LRB-
en-wikipedia-org-4107	1668	19	11C]carfentanil	11c]carfentanil	CD
en-wikipedia-org-4107	1668	20	injection	injection	NN
en-wikipedia-org-4107	1668	21	,	,	,
en-wikipedia-org-4107	1668	22	reduced	reduce	VBN
en-wikipedia-org-4107	1668	23	BPND	BPND	NNP
en-wikipedia-org-4107	1668	24	values	value	NNS
en-wikipedia-org-4107	1668	25	by	by	IN
en-wikipedia-org-4107	1668	26	2–10	2–10	CD
en-wikipedia-org-4107	1668	27	%	%	NN
en-wikipedia-org-4107	1668	28	.	.	.
en-wikipedia-org-4107	1669	1	The	the	DT
en-wikipedia-org-4107	1669	2	results	result	NNS
en-wikipedia-org-4107	1669	3	were	be	VBD
en-wikipedia-org-4107	1669	4	confirmed	confirm	VBN
en-wikipedia-org-4107	1669	5	in	in	IN
en-wikipedia-org-4107	1669	6	another	another	DT
en-wikipedia-org-4107	1669	7	group	group	NN
en-wikipedia-org-4107	1669	8	of	of	IN
en-wikipedia-org-4107	1669	9	subjects	subject	NNS
en-wikipedia-org-4107	1669	10	(	(	-LRB-
en-wikipedia-org-4107	1669	11	Mick	Mick	NNP
en-wikipedia-org-4107	1669	12	et	et	NNP
en-wikipedia-org-4107	1669	13	al	al	NNP
en-wikipedia-org-4107	1669	14	.	.	.
en-wikipedia-org-4107	1670	1	2014	2014	CD
en-wikipedia-org-4107	1670	2	)	)	-RRB-
en-wikipedia-org-4107	1670	3	.	.	.
en-wikipedia-org-4107	1671	1	However	however	RB
en-wikipedia-org-4107	1671	2	,	,	,
en-wikipedia-org-4107	1671	3	Guterstam	Guterstam	NNPS
en-wikipedia-org-4107	1671	4	and	and	CC
en-wikipedia-org-4107	1671	5	colleagues	colleague	NNS
en-wikipedia-org-4107	1671	6	observed	observe	VBD
en-wikipedia-org-4107	1671	7	no	no	DT
en-wikipedia-org-4107	1671	8	change	change	NN
en-wikipedia-org-4107	1671	9	in	in	IN
en-wikipedia-org-4107	1671	10	[	[	-LRB-
en-wikipedia-org-4107	1671	11	11C]carfentanil	11c]carfentanil	CD
en-wikipedia-org-4107	1671	12	binding	bind	VBG
en-wikipedia-org-4107	1671	13	when	when	WRB
en-wikipedia-org-4107	1671	14	d	d	NN
en-wikipedia-org-4107	1671	15	-	-	HYPH
en-wikipedia-org-4107	1671	16	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1671	17	,	,	,
en-wikipedia-org-4107	1671	18	0.3	0.3	CD
en-wikipedia-org-4107	1671	19	 	  	_SP
en-wikipedia-org-4107	1671	20	mg	mg	NNP
en-wikipedia-org-4107	1671	21	/	/	SYM
en-wikipedia-org-4107	1671	22	kg	kg	NNP
en-wikipedia-org-4107	1671	23	,	,	,
en-wikipedia-org-4107	1671	24	was	be	VBD
en-wikipedia-org-4107	1671	25	administered	administer	VBN
en-wikipedia-org-4107	1671	26	intravenously	intravenously	RB
en-wikipedia-org-4107	1671	27	directly	directly	RB
en-wikipedia-org-4107	1671	28	before	before	IN
en-wikipedia-org-4107	1671	29	injection	injection	NN
en-wikipedia-org-4107	1671	30	of	of	IN
en-wikipedia-org-4107	1671	31	[	[	-LRB-
en-wikipedia-org-4107	1671	32	11C]carfentanil	11c]carfentanil	CD
en-wikipedia-org-4107	1671	33	(	(	-LRB-
en-wikipedia-org-4107	1671	34	Guterstam	Guterstam	NNP
en-wikipedia-org-4107	1671	35	et	et	NNP
en-wikipedia-org-4107	1671	36	al	al	NNP
en-wikipedia-org-4107	1671	37	.	.	.
en-wikipedia-org-4107	1672	1	2013	2013	CD
en-wikipedia-org-4107	1672	2	)	)	-RRB-
en-wikipedia-org-4107	1672	3	.	.	.
en-wikipedia-org-4107	1673	1	It	-PRON-	PRP
en-wikipedia-org-4107	1673	2	has	have	VBZ
en-wikipedia-org-4107	1673	3	been	be	VBN
en-wikipedia-org-4107	1673	4	hypothesized	hypothesize	VBN
en-wikipedia-org-4107	1673	5	that	that	IN
en-wikipedia-org-4107	1673	6	this	this	DT
en-wikipedia-org-4107	1673	7	discrepancy	discrepancy	NN
en-wikipedia-org-4107	1673	8	may	may	MD
en-wikipedia-org-4107	1673	9	be	be	VB
en-wikipedia-org-4107	1673	10	related	relate	VBN
en-wikipedia-org-4107	1673	11	to	to	IN
en-wikipedia-org-4107	1673	12	delayed	delay	VBN
en-wikipedia-org-4107	1673	13	increases	increase	NNS
en-wikipedia-org-4107	1673	14	in	in	IN
en-wikipedia-org-4107	1673	15	extracellular	extracellular	JJ
en-wikipedia-org-4107	1673	16	opioid	opioid	JJ
en-wikipedia-org-4107	1673	17	peptide	peptide	NN
en-wikipedia-org-4107	1673	18	concentrations	concentration	NNS
en-wikipedia-org-4107	1673	19	following	follow	VBG
en-wikipedia-org-4107	1673	20	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1673	21	-	-	HYPH
en-wikipedia-org-4107	1673	22	evoked	evoke	VBN
en-wikipedia-org-4107	1673	23	monoamine	monoamine	NN
en-wikipedia-org-4107	1673	24	release	release	NN
en-wikipedia-org-4107	1673	25	(	(	-LRB-
en-wikipedia-org-4107	1673	26	Colasanti	Colasanti	NNP
en-wikipedia-org-4107	1673	27	et	et	FW
en-wikipedia-org-4107	1673	28	al	al	NNP
en-wikipedia-org-4107	1673	29	.	.	.
en-wikipedia-org-4107	1674	1	2012	2012	CD
en-wikipedia-org-4107	1674	2	;	;	:
en-wikipedia-org-4107	1674	3	Mick	Mick	NNP
en-wikipedia-org-4107	1674	4	et	et	NNP
en-wikipedia-org-4107	1674	5	al	al	NNP
en-wikipedia-org-4107	1674	6	.	.	.
en-wikipedia-org-4107	1675	1	2014	2014	CD
en-wikipedia-org-4107	1675	2	)	)	-RRB-
en-wikipedia-org-4107	1675	3	.	.	.
en-wikipedia-org-4107	1676	1	^	^	NNP
en-wikipedia-org-4107	1676	2	a	a	DT
en-wikipedia-org-4107	1676	3	b	b	NN
en-wikipedia-org-4107	1676	4	Loseth	Loseth	NNP
en-wikipedia-org-4107	1676	5	GE	GE	NNP
en-wikipedia-org-4107	1676	6	,	,	,
en-wikipedia-org-4107	1676	7	Ellingsen	Ellingsen	NNP
en-wikipedia-org-4107	1676	8	DM	DM	NNP
en-wikipedia-org-4107	1676	9	,	,	,
en-wikipedia-org-4107	1676	10	Leknes	Leknes	NNP
en-wikipedia-org-4107	1676	11	S	S	NNP
en-wikipedia-org-4107	1676	12	(	(	-LRB-
en-wikipedia-org-4107	1676	13	December	December	NNP
en-wikipedia-org-4107	1676	14	2014	2014	CD
en-wikipedia-org-4107	1676	15	)	)	-RRB-
en-wikipedia-org-4107	1676	16	.	.	.
en-wikipedia-org-4107	1677	1	"	"	``
en-wikipedia-org-4107	1677	2	State	state	NN
en-wikipedia-org-4107	1677	3	-	-	HYPH
en-wikipedia-org-4107	1677	4	dependent	dependent	JJ
en-wikipedia-org-4107	1677	5	μ	μ	NN
en-wikipedia-org-4107	1677	6	-	-	HYPH
en-wikipedia-org-4107	1677	7	opioid	opioid	NN
en-wikipedia-org-4107	1677	8	modulation	modulation	NN
en-wikipedia-org-4107	1677	9	of	of	IN
en-wikipedia-org-4107	1677	10	social	social	NNP
en-wikipedia-org-4107	1677	11	motivation	motivation	NNP
en-wikipedia-org-4107	1677	12	"	"	''
en-wikipedia-org-4107	1677	13	.	.	.
en-wikipedia-org-4107	1678	1	Frontiers	frontier	NNS
en-wikipedia-org-4107	1678	2	in	in	IN
en-wikipedia-org-4107	1678	3	Behavioral	Behavioral	NNP
en-wikipedia-org-4107	1678	4	Neuroscience	Neuroscience	NNP
en-wikipedia-org-4107	1678	5	.	.	.
en-wikipedia-org-4107	1679	1	8	8	CD
en-wikipedia-org-4107	1679	2	:	:	:
en-wikipedia-org-4107	1679	3	430	430	CD
en-wikipedia-org-4107	1679	4	.	.	.
en-wikipedia-org-4107	1679	5	doi:10.3389	doi:10.3389	NNP
en-wikipedia-org-4107	1679	6	/	/	SYM
en-wikipedia-org-4107	1679	7	fnbeh.2014.00430	fnbeh.2014.00430	ADD
en-wikipedia-org-4107	1679	8	.	.	.
en-wikipedia-org-4107	1680	1	PMC	PMC	NNP
en-wikipedia-org-4107	1680	2	 	  	_SP
en-wikipedia-org-4107	1680	3	4264475	4264475	CD
en-wikipedia-org-4107	1680	4	.	.	.
en-wikipedia-org-4107	1681	1	PMID	PMID	NNP
en-wikipedia-org-4107	1681	2	 	  	_SP
en-wikipedia-org-4107	1681	3	25565999	25565999	CD
en-wikipedia-org-4107	1681	4	.	.	.
en-wikipedia-org-4107	1682	1	Similar	similar	JJ
en-wikipedia-org-4107	1682	2	MOR	MOR	NNP
en-wikipedia-org-4107	1682	3	activation	activation	NN
en-wikipedia-org-4107	1682	4	patterns	pattern	NNS
en-wikipedia-org-4107	1682	5	were	be	VBD
en-wikipedia-org-4107	1682	6	reported	report	VBN
en-wikipedia-org-4107	1682	7	during	during	IN
en-wikipedia-org-4107	1682	8	positive	positive	JJ
en-wikipedia-org-4107	1682	9	mood	mood	NN
en-wikipedia-org-4107	1682	10	induced	induce	VBN
en-wikipedia-org-4107	1682	11	by	by	IN
en-wikipedia-org-4107	1682	12	an	an	DT
en-wikipedia-org-4107	1682	13	amusing	amusing	JJ
en-wikipedia-org-4107	1682	14	video	video	NN
en-wikipedia-org-4107	1682	15	clip	clip	NN
en-wikipedia-org-4107	1682	16	(	(	-LRB-
en-wikipedia-org-4107	1682	17	Koepp	Koepp	NNP
en-wikipedia-org-4107	1682	18	et	et	NNP
en-wikipedia-org-4107	1682	19	al	al	NNP
en-wikipedia-org-4107	1682	20	.	.	NNP
en-wikipedia-org-4107	1682	21	,	,	,
en-wikipedia-org-4107	1682	22	2009	2009	CD
en-wikipedia-org-4107	1682	23	)	)	-RRB-
en-wikipedia-org-4107	1682	24	and	and	CC
en-wikipedia-org-4107	1682	25	following	follow	VBG
en-wikipedia-org-4107	1682	26	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1682	27	administration	administration	NN
en-wikipedia-org-4107	1682	28	in	in	IN
en-wikipedia-org-4107	1682	29	humans	human	NNS
en-wikipedia-org-4107	1682	30	(	(	-LRB-
en-wikipedia-org-4107	1682	31	Colasanti	Colasanti	NNP
en-wikipedia-org-4107	1682	32	et	et	FW
en-wikipedia-org-4107	1682	33	al	al	NNP
en-wikipedia-org-4107	1682	34	.	.	NNP
en-wikipedia-org-4107	1682	35	,	,	,
en-wikipedia-org-4107	1682	36	2012	2012	CD
en-wikipedia-org-4107	1682	37	)	)	-RRB-
en-wikipedia-org-4107	1682	38	.	.	.
en-wikipedia-org-4107	1683	1	^	^	NNP
en-wikipedia-org-4107	1683	2	a	a	DT
en-wikipedia-org-4107	1683	3	b	b	NN
en-wikipedia-org-4107	1683	4	Colasanti	Colasanti	NNP
en-wikipedia-org-4107	1683	5	A	A	NNP
en-wikipedia-org-4107	1683	6	,	,	,
en-wikipedia-org-4107	1683	7	Searle	Searle	NNP
en-wikipedia-org-4107	1683	8	GE	GE	NNP
en-wikipedia-org-4107	1683	9	,	,	,
en-wikipedia-org-4107	1683	10	Long	Long	NNP
en-wikipedia-org-4107	1683	11	CJ	CJ	NNP
en-wikipedia-org-4107	1683	12	,	,	,
en-wikipedia-org-4107	1683	13	Hill	Hill	NNP
en-wikipedia-org-4107	1683	14	SP	SP	NNP
en-wikipedia-org-4107	1683	15	,	,	,
en-wikipedia-org-4107	1683	16	Reiley	Reiley	NNP
en-wikipedia-org-4107	1683	17	RR	RR	NNP
en-wikipedia-org-4107	1683	18	,	,	,
en-wikipedia-org-4107	1683	19	Quelch	quelch	NN
en-wikipedia-org-4107	1683	20	D	D	NNP
en-wikipedia-org-4107	1683	21	,	,	,
en-wikipedia-org-4107	1683	22	Erritzoe	Erritzoe	NNP
en-wikipedia-org-4107	1683	23	D	D	NNP
en-wikipedia-org-4107	1683	24	,	,	,
en-wikipedia-org-4107	1683	25	Tziortzi	Tziortzi	NNP
en-wikipedia-org-4107	1683	26	AC	AC	NNP
en-wikipedia-org-4107	1683	27	,	,	,
en-wikipedia-org-4107	1683	28	Reed	Reed	NNP
en-wikipedia-org-4107	1683	29	LJ	LJ	NNP
en-wikipedia-org-4107	1683	30	,	,	,
en-wikipedia-org-4107	1683	31	Lingford	Lingford	NNP
en-wikipedia-org-4107	1683	32	-	-	HYPH
en-wikipedia-org-4107	1683	33	Hughes	Hughes	NNP
en-wikipedia-org-4107	1683	34	AR	AR	NNP
en-wikipedia-org-4107	1683	35	,	,	,
en-wikipedia-org-4107	1683	36	Waldman	Waldman	NNP
en-wikipedia-org-4107	1683	37	AD	AD	NNP
en-wikipedia-org-4107	1683	38	,	,	,
en-wikipedia-org-4107	1683	39	Schruers	Schruers	NNP
en-wikipedia-org-4107	1683	40	KR	KR	NNP
en-wikipedia-org-4107	1683	41	,	,	,
en-wikipedia-org-4107	1683	42	Matthews	Matthews	NNP
en-wikipedia-org-4107	1683	43	PM	PM	NNP
en-wikipedia-org-4107	1683	44	,	,	,
en-wikipedia-org-4107	1683	45	Gunn	Gunn	NNP
en-wikipedia-org-4107	1683	46	RN	RN	NNP
en-wikipedia-org-4107	1683	47	,	,	,
en-wikipedia-org-4107	1683	48	Nutt	Nutt	NNP
en-wikipedia-org-4107	1683	49	DJ	DJ	NNP
en-wikipedia-org-4107	1683	50	,	,	,
en-wikipedia-org-4107	1683	51	Rabiner	rabiner	NN
en-wikipedia-org-4107	1683	52	EA	EA	NNP
en-wikipedia-org-4107	1683	53	(	(	-LRB-
en-wikipedia-org-4107	1683	54	September	September	NNP
en-wikipedia-org-4107	1683	55	2012	2012	CD
en-wikipedia-org-4107	1683	56	)	)	-RRB-
en-wikipedia-org-4107	1683	57	.	.	.
en-wikipedia-org-4107	1684	1	"	"	``
en-wikipedia-org-4107	1684	2	Endogenous	endogenous	JJ
en-wikipedia-org-4107	1684	3	opioid	opioid	NN
en-wikipedia-org-4107	1684	4	release	release	NN
en-wikipedia-org-4107	1684	5	in	in	IN
en-wikipedia-org-4107	1684	6	the	the	DT
en-wikipedia-org-4107	1684	7	human	human	JJ
en-wikipedia-org-4107	1684	8	brain	brain	NN
en-wikipedia-org-4107	1684	9	reward	reward	NN
en-wikipedia-org-4107	1684	10	system	system	NN
en-wikipedia-org-4107	1684	11	induced	induce	VBN
en-wikipedia-org-4107	1684	12	by	by	IN
en-wikipedia-org-4107	1684	13	acute	acute	NNP
en-wikipedia-org-4107	1684	14	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1684	15	administration	administration	NNP
en-wikipedia-org-4107	1684	16	"	"	''
en-wikipedia-org-4107	1684	17	.	.	.
en-wikipedia-org-4107	1685	1	Biological	biological	JJ
en-wikipedia-org-4107	1685	2	Psychiatry	Psychiatry	NNP
en-wikipedia-org-4107	1685	3	.	.	.
en-wikipedia-org-4107	1686	1	72	72	CD
en-wikipedia-org-4107	1686	2	(	(	-LRB-
en-wikipedia-org-4107	1686	3	5	5	CD
en-wikipedia-org-4107	1686	4	)	)	-RRB-
en-wikipedia-org-4107	1686	5	:	:	:
en-wikipedia-org-4107	1686	6	371–377	371–377	CD
en-wikipedia-org-4107	1686	7	.	.	.
en-wikipedia-org-4107	1687	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1687	2	/	/	SYM
en-wikipedia-org-4107	1687	3	j.biopsych.2012.01.027	j.biopsych.2012.01.027	JJ
en-wikipedia-org-4107	1687	4	.	.	.
en-wikipedia-org-4107	1688	1	PMID	PMID	NNP
en-wikipedia-org-4107	1688	2	 	  	_SP
en-wikipedia-org-4107	1688	3	22386378	22386378	CD
en-wikipedia-org-4107	1688	4	.	.	.
en-wikipedia-org-4107	1689	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1689	2	 	  	_SP
en-wikipedia-org-4107	1689	3	18555036	18555036	CD
en-wikipedia-org-4107	1689	4	.	.	.
en-wikipedia-org-4107	1690	1	^	^	NNP
en-wikipedia-org-4107	1690	2	a	a	DT
en-wikipedia-org-4107	1690	3	b	b	NN
en-wikipedia-org-4107	1690	4	c	c	NN
en-wikipedia-org-4107	1690	5	Gunne	Gunne	NNP
en-wikipedia-org-4107	1690	6	LM	LM	NNP
en-wikipedia-org-4107	1690	7	(	(	-LRB-
en-wikipedia-org-4107	1690	8	2013	2013	CD
en-wikipedia-org-4107	1690	9	)	)	-RRB-
en-wikipedia-org-4107	1690	10	.	.	.
en-wikipedia-org-4107	1691	1	"	"	``
en-wikipedia-org-4107	1691	2	Effects	effect	NNS
en-wikipedia-org-4107	1691	3	of	of	IN
en-wikipedia-org-4107	1691	4	Amphetamines	Amphetamines	NNPS
en-wikipedia-org-4107	1691	5	in	in	IN
en-wikipedia-org-4107	1691	6	Humans	Humans	NNPS
en-wikipedia-org-4107	1691	7	"	"	''
en-wikipedia-org-4107	1691	8	.	.	.
en-wikipedia-org-4107	1692	1	Drug	Drug	NNP
en-wikipedia-org-4107	1692	2	Addiction	Addiction	NNP
en-wikipedia-org-4107	1692	3	II	ii	CD
en-wikipedia-org-4107	1692	4	:	:	:
en-wikipedia-org-4107	1692	5	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1692	6	,	,	,
en-wikipedia-org-4107	1692	7	Psychotogen	Psychotogen	NNP
en-wikipedia-org-4107	1692	8	,	,	,
en-wikipedia-org-4107	1692	9	and	and	CC
en-wikipedia-org-4107	1692	10	Marihuana	Marihuana	NNP
en-wikipedia-org-4107	1692	11	Dependence	Dependence	NNP
en-wikipedia-org-4107	1692	12	.	.	.
en-wikipedia-org-4107	1693	1	Berlin	Berlin	NNP
en-wikipedia-org-4107	1693	2	,	,	,
en-wikipedia-org-4107	1693	3	Germany	Germany	NNP
en-wikipedia-org-4107	1693	4	;	;	:
en-wikipedia-org-4107	1693	5	Heidelberg	Heidelberg	NNP
en-wikipedia-org-4107	1693	6	,	,	,
en-wikipedia-org-4107	1693	7	Germany	Germany	NNP
en-wikipedia-org-4107	1693	8	:	:	:
en-wikipedia-org-4107	1693	9	Springer	Springer	NNP
en-wikipedia-org-4107	1693	10	.	.	.
en-wikipedia-org-4107	1694	1	pp	pp	NNP
en-wikipedia-org-4107	1694	2	.	.	.
en-wikipedia-org-4107	1695	1	247–260	247–260	CD
en-wikipedia-org-4107	1695	2	.	.	.
en-wikipedia-org-4107	1696	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	1696	2	 	  	_SP
en-wikipedia-org-4107	1696	3	9783642667091	9783642667091	CD
en-wikipedia-org-4107	1696	4	.	.	.
en-wikipedia-org-4107	1697	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1697	2	4	4	CD
en-wikipedia-org-4107	1697	3	December	December	NNP
en-wikipedia-org-4107	1697	4	2015	2015	CD
en-wikipedia-org-4107	1697	5	.	.	.
en-wikipedia-org-4107	1698	1	^	^	NNP
en-wikipedia-org-4107	1698	2	a	a	DT
en-wikipedia-org-4107	1698	3	b	b	NNP
en-wikipedia-org-4107	1698	4	c	c	NNP
en-wikipedia-org-4107	1698	5	Oswald	Oswald	NNP
en-wikipedia-org-4107	1698	6	LM	LM	NNP
en-wikipedia-org-4107	1698	7	,	,	,
en-wikipedia-org-4107	1698	8	Wong	Wong	NNP
en-wikipedia-org-4107	1698	9	DF	DF	NNP
en-wikipedia-org-4107	1698	10	,	,	,
en-wikipedia-org-4107	1698	11	McCaul	McCaul	NNP
en-wikipedia-org-4107	1698	12	M	M	NNP
en-wikipedia-org-4107	1698	13	,	,	,
en-wikipedia-org-4107	1698	14	Zhou	Zhou	NNP
en-wikipedia-org-4107	1698	15	Y	Y	NNP
en-wikipedia-org-4107	1698	16	,	,	,
en-wikipedia-org-4107	1698	17	Kuwabara	Kuwabara	NNP
en-wikipedia-org-4107	1698	18	H	H	NNP
en-wikipedia-org-4107	1698	19	,	,	,
en-wikipedia-org-4107	1698	20	Choi	Choi	NNP
en-wikipedia-org-4107	1698	21	L	L	NNP
en-wikipedia-org-4107	1698	22	,	,	,
en-wikipedia-org-4107	1698	23	Brasic	Brasic	NNP
en-wikipedia-org-4107	1698	24	J	J	NNP
en-wikipedia-org-4107	1698	25	,	,	,
en-wikipedia-org-4107	1698	26	Wand	Wand	NNP
en-wikipedia-org-4107	1698	27	GS	GS	NNP
en-wikipedia-org-4107	1698	28	(	(	-LRB-
en-wikipedia-org-4107	1698	29	April	April	NNP
en-wikipedia-org-4107	1698	30	2005	2005	CD
en-wikipedia-org-4107	1698	31	)	)	-RRB-
en-wikipedia-org-4107	1698	32	.	.	.
en-wikipedia-org-4107	1699	1	"	"	``
en-wikipedia-org-4107	1699	2	Relationships	relationship	NNS
en-wikipedia-org-4107	1699	3	among	among	IN
en-wikipedia-org-4107	1699	4	ventral	ventral	JJ
en-wikipedia-org-4107	1699	5	striatal	striatal	JJ
en-wikipedia-org-4107	1699	6	dopamine	dopamine	NN
en-wikipedia-org-4107	1699	7	release	release	NN
en-wikipedia-org-4107	1699	8	,	,	,
en-wikipedia-org-4107	1699	9	cortisol	cortisol	NNP
en-wikipedia-org-4107	1699	10	secretion	secretion	NN
en-wikipedia-org-4107	1699	11	,	,	,
en-wikipedia-org-4107	1699	12	and	and	CC
en-wikipedia-org-4107	1699	13	subjective	subjective	JJ
en-wikipedia-org-4107	1699	14	responses	response	NNS
en-wikipedia-org-4107	1699	15	to	to	TO
en-wikipedia-org-4107	1699	16	amphetamine	amphetamine	VB
en-wikipedia-org-4107	1699	17	"	"	''
en-wikipedia-org-4107	1699	18	.	.	.
en-wikipedia-org-4107	1700	1	Neuropsychopharmacology	neuropsychopharmacology	NN
en-wikipedia-org-4107	1700	2	.	.	.
en-wikipedia-org-4107	1701	1	30	30	CD
en-wikipedia-org-4107	1701	2	(	(	-LRB-
en-wikipedia-org-4107	1701	3	4	4	CD
en-wikipedia-org-4107	1701	4	)	)	-RRB-
en-wikipedia-org-4107	1701	5	:	:	:
en-wikipedia-org-4107	1701	6	821–832	821–832	CD
en-wikipedia-org-4107	1701	7	.	.	.
en-wikipedia-org-4107	1702	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-4107	1702	2	/	/	SYM
en-wikipedia-org-4107	1702	3	sj.npp.1300667	sj.npp.1300667	NNP
en-wikipedia-org-4107	1702	4	.	.	.
en-wikipedia-org-4107	1703	1	PMID	PMID	NNP
en-wikipedia-org-4107	1703	2	 	  	_SP
en-wikipedia-org-4107	1703	3	15702139	15702139	CD
en-wikipedia-org-4107	1703	4	.	.	.
en-wikipedia-org-4107	1704	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1704	2	 	  	_SP
en-wikipedia-org-4107	1704	3	12302237	12302237	CD
en-wikipedia-org-4107	1704	4	.	.	.
en-wikipedia-org-4107	1705	1	Findings	finding	NNS
en-wikipedia-org-4107	1705	2	from	from	IN
en-wikipedia-org-4107	1705	3	several	several	JJ
en-wikipedia-org-4107	1705	4	prior	prior	JJ
en-wikipedia-org-4107	1705	5	investigations	investigation	NNS
en-wikipedia-org-4107	1705	6	have	have	VBP
en-wikipedia-org-4107	1705	7	shown	show	VBN
en-wikipedia-org-4107	1705	8	that	that	IN
en-wikipedia-org-4107	1705	9	plasma	plasma	NN
en-wikipedia-org-4107	1705	10	levels	level	NNS
en-wikipedia-org-4107	1705	11	of	of	IN
en-wikipedia-org-4107	1705	12	glucocorticoids	glucocorticoid	NNS
en-wikipedia-org-4107	1705	13	and	and	CC
en-wikipedia-org-4107	1705	14	ACTH	ACTH	NNP
en-wikipedia-org-4107	1705	15	are	be	VBP
en-wikipedia-org-4107	1705	16	increased	increase	VBN
en-wikipedia-org-4107	1705	17	by	by	IN
en-wikipedia-org-4107	1705	18	acute	acute	JJ
en-wikipedia-org-4107	1705	19	administration	administration	NN
en-wikipedia-org-4107	1705	20	of	of	IN
en-wikipedia-org-4107	1705	21	AMPH	AMPH	NNP
en-wikipedia-org-4107	1705	22	in	in	IN
en-wikipedia-org-4107	1705	23	both	both	DT
en-wikipedia-org-4107	1705	24	rodents	rodent	NNS
en-wikipedia-org-4107	1705	25	and	and	CC
en-wikipedia-org-4107	1705	26	humans	human	NNS
en-wikipedia-org-4107	1705	27	^	^	VBP
en-wikipedia-org-4107	1705	28	a	a	DT
en-wikipedia-org-4107	1705	29	b	b	NN
en-wikipedia-org-4107	1705	30	c	c	NNP
en-wikipedia-org-4107	1705	31	d	d	NNP
en-wikipedia-org-4107	1705	32	e	e	NNP
en-wikipedia-org-4107	1705	33	f	f	NNP
en-wikipedia-org-4107	1705	34	g	g	NNP
en-wikipedia-org-4107	1705	35	h	h	NNP
en-wikipedia-org-4107	1705	36	i	i	NN
en-wikipedia-org-4107	1705	37	j	j	NN
en-wikipedia-org-4107	1705	38	Angeli	Angeli	NNP
en-wikipedia-org-4107	1705	39	A	A	NNP
en-wikipedia-org-4107	1705	40	,	,	,
en-wikipedia-org-4107	1705	41	Vaiano	Vaiano	NNP
en-wikipedia-org-4107	1705	42	F	F	NNP
en-wikipedia-org-4107	1705	43	,	,	,
en-wikipedia-org-4107	1705	44	Mari	Mari	NNP
en-wikipedia-org-4107	1705	45	F	F	NNP
en-wikipedia-org-4107	1705	46	,	,	,
en-wikipedia-org-4107	1705	47	Bertol	Bertol	NNP
en-wikipedia-org-4107	1705	48	E	E	NNP
en-wikipedia-org-4107	1705	49	,	,	,
en-wikipedia-org-4107	1705	50	Supuran	Supuran	NNP
en-wikipedia-org-4107	1705	51	CT	CT	NNP
en-wikipedia-org-4107	1705	52	(	(	-LRB-
en-wikipedia-org-4107	1705	53	December	December	NNP
en-wikipedia-org-4107	1705	54	2017	2017	CD
en-wikipedia-org-4107	1705	55	)	)	-RRB-
en-wikipedia-org-4107	1705	56	.	.	.
en-wikipedia-org-4107	1706	1	"	"	``
en-wikipedia-org-4107	1706	2	Psychoactive	psychoactive	JJ
en-wikipedia-org-4107	1706	3	substances	substance	NNS
en-wikipedia-org-4107	1706	4	belonging	belong	VBG
en-wikipedia-org-4107	1706	5	to	to	IN
en-wikipedia-org-4107	1706	6	the	the	DT
en-wikipedia-org-4107	1706	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1706	8	class	class	NN
en-wikipedia-org-4107	1706	9	potently	potently	RB
en-wikipedia-org-4107	1706	10	activate	activate	VBP
en-wikipedia-org-4107	1706	11	brain	brain	NN
en-wikipedia-org-4107	1706	12	carbonic	carbonic	JJ
en-wikipedia-org-4107	1706	13	anhydrase	anhydrase	NNP
en-wikipedia-org-4107	1706	14	isoforms	isoform	NNS
en-wikipedia-org-4107	1706	15	VA	VA	NNP
en-wikipedia-org-4107	1706	16	,	,	,
en-wikipedia-org-4107	1706	17	VB	VB	NNP
en-wikipedia-org-4107	1706	18	,	,	,
en-wikipedia-org-4107	1706	19	VII	VII	NNP
en-wikipedia-org-4107	1706	20	,	,	,
en-wikipedia-org-4107	1706	21	and	and	CC
en-wikipedia-org-4107	1706	22	XII	XII	NNP
en-wikipedia-org-4107	1706	23	"	"	''
en-wikipedia-org-4107	1706	24	.	.	.
en-wikipedia-org-4107	1707	1	Journal	Journal	NNP
en-wikipedia-org-4107	1707	2	of	of	IN
en-wikipedia-org-4107	1707	3	Enzyme	Enzyme	NNP
en-wikipedia-org-4107	1707	4	Inhibition	Inhibition	NNP
en-wikipedia-org-4107	1707	5	and	and	CC
en-wikipedia-org-4107	1707	6	Medicinal	Medicinal	NNP
en-wikipedia-org-4107	1707	7	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	1707	8	.	.	.
en-wikipedia-org-4107	1708	1	32	32	CD
en-wikipedia-org-4107	1708	2	(	(	-LRB-
en-wikipedia-org-4107	1708	3	1	1	CD
en-wikipedia-org-4107	1708	4	)	)	-RRB-
en-wikipedia-org-4107	1708	5	:	:	:
en-wikipedia-org-4107	1708	6	1253–1259	1253–1259	CD
en-wikipedia-org-4107	1708	7	.	.	.
en-wikipedia-org-4107	1709	1	doi:10.1080/14756366.2017.1375485	doi:10.1080/14756366.2017.1375485	NNP
en-wikipedia-org-4107	1709	2	.	.	.
en-wikipedia-org-4107	1710	1	PMC	PMC	NNP
en-wikipedia-org-4107	1710	2	 	  	_SP
en-wikipedia-org-4107	1710	3	6009978	6009978	CD
en-wikipedia-org-4107	1710	4	.	.	.
en-wikipedia-org-4107	1711	1	PMID	PMID	NNP
en-wikipedia-org-4107	1711	2	 	  	_SP
en-wikipedia-org-4107	1711	3	28936885	28936885	CD
en-wikipedia-org-4107	1711	4	.	.	.
en-wikipedia-org-4107	1712	1	Here	here	RB
en-wikipedia-org-4107	1712	2	,	,	,
en-wikipedia-org-4107	1712	3	we	-PRON-	PRP
en-wikipedia-org-4107	1712	4	report	report	VBP
en-wikipedia-org-4107	1712	5	the	the	DT
en-wikipedia-org-4107	1712	6	first	first	JJ
en-wikipedia-org-4107	1712	7	such	such	JJ
en-wikipedia-org-4107	1712	8	study	study	NN
en-wikipedia-org-4107	1712	9	,	,	,
en-wikipedia-org-4107	1712	10	showing	show	VBG
en-wikipedia-org-4107	1712	11	that	that	DT
en-wikipedia-org-4107	1712	12	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1712	13	,	,	,
en-wikipedia-org-4107	1712	14	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	1712	15	,	,	,
en-wikipedia-org-4107	1712	16	phentermine	phentermine	NN
en-wikipedia-org-4107	1712	17	,	,	,
en-wikipedia-org-4107	1712	18	mephentermine	mephentermine	NN
en-wikipedia-org-4107	1712	19	,	,	,
en-wikipedia-org-4107	1712	20	and	and	CC
en-wikipedia-org-4107	1712	21	chlorphenteramine	chlorphenteramine	NN
en-wikipedia-org-4107	1712	22	,	,	,
en-wikipedia-org-4107	1712	23	potently	potently	RB
en-wikipedia-org-4107	1712	24	activate	activate	VB
en-wikipedia-org-4107	1712	25	several	several	JJ
en-wikipedia-org-4107	1712	26	CA	CA	NNP
en-wikipedia-org-4107	1712	27	isoforms	isoform	NNS
en-wikipedia-org-4107	1712	28	,	,	,
en-wikipedia-org-4107	1712	29	some	some	DT
en-wikipedia-org-4107	1712	30	of	of	IN
en-wikipedia-org-4107	1712	31	which	which	WDT
en-wikipedia-org-4107	1712	32	are	be	VBP
en-wikipedia-org-4107	1712	33	highly	highly	RB
en-wikipedia-org-4107	1712	34	abundant	abundant	JJ
en-wikipedia-org-4107	1712	35	in	in	IN
en-wikipedia-org-4107	1712	36	the	the	DT
en-wikipedia-org-4107	1712	37	brain	brain	NN
en-wikipedia-org-4107	1712	38	,	,	,
en-wikipedia-org-4107	1712	39	where	where	WRB
en-wikipedia-org-4107	1712	40	they	-PRON-	PRP
en-wikipedia-org-4107	1712	41	play	play	VBP
en-wikipedia-org-4107	1712	42	important	important	JJ
en-wikipedia-org-4107	1712	43	functions	function	NNS
en-wikipedia-org-4107	1712	44	connected	connect	VBN
en-wikipedia-org-4107	1712	45	to	to	IN
en-wikipedia-org-4107	1712	46	cognition	cognition	NN
en-wikipedia-org-4107	1712	47	and	and	CC
en-wikipedia-org-4107	1712	48	memory	memory	NN
en-wikipedia-org-4107	1712	49	,	,	,
en-wikipedia-org-4107	1712	50	among	among	IN
en-wikipedia-org-4107	1712	51	others26,27	others26,27	NNP
en-wikipedia-org-4107	1712	52	.	.	.
en-wikipedia-org-4107	1713	1	...	...	NFP
en-wikipedia-org-4107	1713	2	We	-PRON-	PRP
en-wikipedia-org-4107	1713	3	investigated	investigate	VBD
en-wikipedia-org-4107	1713	4	psychotropic	psychotropic	JJ
en-wikipedia-org-4107	1713	5	amines	amine	NNS
en-wikipedia-org-4107	1713	6	based	base	VBN
en-wikipedia-org-4107	1713	7	on	on	IN
en-wikipedia-org-4107	1713	8	the	the	DT
en-wikipedia-org-4107	1713	9	phenethylamine	phenethylamine	NN
en-wikipedia-org-4107	1713	10	scaffold	scaffold	NN
en-wikipedia-org-4107	1713	11	,	,	,
en-wikipedia-org-4107	1713	12	such	such	JJ
en-wikipedia-org-4107	1713	13	as	as	IN
en-wikipedia-org-4107	1713	14	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1713	15	5	5	CD
en-wikipedia-org-4107	1713	16	,	,	,
en-wikipedia-org-4107	1713	17	methamphetamine	methamphetamine	NNP
en-wikipedia-org-4107	1713	18	6	6	CD
en-wikipedia-org-4107	1713	19	,	,	,
en-wikipedia-org-4107	1713	20	phentermine	phentermine	NNP
en-wikipedia-org-4107	1713	21	7	7	CD
en-wikipedia-org-4107	1713	22	,	,	,
en-wikipedia-org-4107	1713	23	mephentermine	mephentermine	NN
en-wikipedia-org-4107	1713	24	8	8	CD
en-wikipedia-org-4107	1713	25	,	,	,
en-wikipedia-org-4107	1713	26	and	and	CC
en-wikipedia-org-4107	1713	27	the	the	DT
en-wikipedia-org-4107	1713	28	structurally	structurally	RB
en-wikipedia-org-4107	1713	29	diverse	diverse	JJ
en-wikipedia-org-4107	1713	30	chlorphenteramine	chlorphenteramine	NN
en-wikipedia-org-4107	1713	31	9	9	CD
en-wikipedia-org-4107	1713	32	,	,	,
en-wikipedia-org-4107	1713	33	for	for	IN
en-wikipedia-org-4107	1713	34	their	-PRON-	PRP$
en-wikipedia-org-4107	1713	35	activating	activate	VBG
en-wikipedia-org-4107	1713	36	effects	effect	NNS
en-wikipedia-org-4107	1713	37	on	on	IN
en-wikipedia-org-4107	1713	38	11	11	CD
en-wikipedia-org-4107	1713	39	CA	CA	NNP
en-wikipedia-org-4107	1713	40	isoforms	isoform	NNS
en-wikipedia-org-4107	1713	41	of	of	IN
en-wikipedia-org-4107	1713	42	human	human	JJ
en-wikipedia-org-4107	1713	43	origin	origin	NN
en-wikipedia-org-4107	1713	44	 	  	_SP
en-wikipedia-org-4107	1713	45	...	...	.
en-wikipedia-org-4107	1714	1	The	the	DT
en-wikipedia-org-4107	1714	2	widespread	widespread	JJ
en-wikipedia-org-4107	1714	3	hCA	hca	NN
en-wikipedia-org-4107	1714	4	I	-PRON-	PRP
en-wikipedia-org-4107	1714	5	and	and	CC
en-wikipedia-org-4107	1714	6	II	II	NNP
en-wikipedia-org-4107	1714	7	,	,	,
en-wikipedia-org-4107	1714	8	the	the	DT
en-wikipedia-org-4107	1714	9	secreted	secreted	JJ
en-wikipedia-org-4107	1714	10	hCA	hca	NN
en-wikipedia-org-4107	1714	11	VI	VI	NNP
en-wikipedia-org-4107	1714	12	,	,	,
en-wikipedia-org-4107	1714	13	as	as	RB
en-wikipedia-org-4107	1714	14	well	well	RB
en-wikipedia-org-4107	1714	15	as	as	IN
en-wikipedia-org-4107	1714	16	the	the	DT
en-wikipedia-org-4107	1714	17	cytosolic	cytosolic	JJ
en-wikipedia-org-4107	1714	18	hCA	hca	NN
en-wikipedia-org-4107	1714	19	XIII	xiii	NN
en-wikipedia-org-4107	1714	20	and	and	CC
en-wikipedia-org-4107	1714	21	membrane	membrane	NN
en-wikipedia-org-4107	1714	22	-	-	HYPH
en-wikipedia-org-4107	1714	23	bound	bind	VBN
en-wikipedia-org-4107	1714	24	hCA	hCA	NNP
en-wikipedia-org-4107	1714	25	IX	ix	NN
en-wikipedia-org-4107	1714	26	and	and	CC
en-wikipedia-org-4107	1714	27	XIV	XIV	NNP
en-wikipedia-org-4107	1714	28	were	be	VBD
en-wikipedia-org-4107	1714	29	poorly	poorly	RB
en-wikipedia-org-4107	1714	30	activated	activate	VBN
en-wikipedia-org-4107	1714	31	by	by	IN
en-wikipedia-org-4107	1714	32	these	these	DT
en-wikipedia-org-4107	1714	33	amines	amine	NNS
en-wikipedia-org-4107	1714	34	,	,	,
en-wikipedia-org-4107	1714	35	whereas	whereas	IN
en-wikipedia-org-4107	1714	36	the	the	DT
en-wikipedia-org-4107	1714	37	extracellular	extracellular	NNP
en-wikipedia-org-4107	1714	38	hCA	hca	NN
en-wikipedia-org-4107	1714	39	IV	IV	NNP
en-wikipedia-org-4107	1714	40	,	,	,
en-wikipedia-org-4107	1714	41	the	the	DT
en-wikipedia-org-4107	1714	42	mitochondrial	mitochondrial	NN
en-wikipedia-org-4107	1714	43	enzymes	enzyme	VBZ
en-wikipedia-org-4107	1714	44	hCA	hca	VBP
en-wikipedia-org-4107	1714	45	VA	VA	NNP
en-wikipedia-org-4107	1714	46	/	/	SYM
en-wikipedia-org-4107	1714	47	VB	VB	NNP
en-wikipedia-org-4107	1714	48	,	,	,
en-wikipedia-org-4107	1714	49	the	the	DT
en-wikipedia-org-4107	1714	50	cytosolic	cytosolic	NN
en-wikipedia-org-4107	1714	51	hCA	hca	NN
en-wikipedia-org-4107	1714	52	VII	VII	NNP
en-wikipedia-org-4107	1714	53	,	,	,
en-wikipedia-org-4107	1714	54	and	and	CC
en-wikipedia-org-4107	1714	55	the	the	DT
en-wikipedia-org-4107	1714	56	transmembrane	transmembrane	NNP
en-wikipedia-org-4107	1714	57	isoform	isoform	NN
en-wikipedia-org-4107	1714	58	hCA	hca	NN
en-wikipedia-org-4107	1714	59	XII	XII	NNP
en-wikipedia-org-4107	1714	60	were	be	VBD
en-wikipedia-org-4107	1714	61	potently	potently	RB
en-wikipedia-org-4107	1714	62	activated	activate	VBN
en-wikipedia-org-4107	1714	63	.	.	.
en-wikipedia-org-4107	1715	1	Some	some	DT
en-wikipedia-org-4107	1715	2	of	of	IN
en-wikipedia-org-4107	1715	3	these	these	DT
en-wikipedia-org-4107	1715	4	enzymes	enzyme	NNS
en-wikipedia-org-4107	1715	5	(	(	-LRB-
en-wikipedia-org-4107	1715	6	hCA	hCA	NNP
en-wikipedia-org-4107	1715	7	VII	VII	NNP
en-wikipedia-org-4107	1715	8	,	,	,
en-wikipedia-org-4107	1715	9	VA	VA	NNP
en-wikipedia-org-4107	1715	10	,	,	,
en-wikipedia-org-4107	1715	11	VB	VB	NNP
en-wikipedia-org-4107	1715	12	,	,	,
en-wikipedia-org-4107	1715	13	XII	XII	NNP
en-wikipedia-org-4107	1715	14	)	)	-RRB-
en-wikipedia-org-4107	1715	15	are	be	VBP
en-wikipedia-org-4107	1715	16	abundant	abundant	JJ
en-wikipedia-org-4107	1715	17	in	in	IN
en-wikipedia-org-4107	1715	18	the	the	DT
en-wikipedia-org-4107	1715	19	brain	brain	NN
en-wikipedia-org-4107	1715	20	,	,	,
en-wikipedia-org-4107	1715	21	raising	raise	VBG
en-wikipedia-org-4107	1715	22	the	the	DT
en-wikipedia-org-4107	1715	23	possibility	possibility	NN
en-wikipedia-org-4107	1715	24	that	that	IN
en-wikipedia-org-4107	1715	25	some	some	DT
en-wikipedia-org-4107	1715	26	of	of	IN
en-wikipedia-org-4107	1715	27	the	the	DT
en-wikipedia-org-4107	1715	28	cognitive	cognitive	JJ
en-wikipedia-org-4107	1715	29	effects	effect	NNS
en-wikipedia-org-4107	1715	30	of	of	IN
en-wikipedia-org-4107	1715	31	such	such	JJ
en-wikipedia-org-4107	1715	32	psychoactive	psychoactive	JJ
en-wikipedia-org-4107	1715	33	substances	substance	NNS
en-wikipedia-org-4107	1715	34	might	may	MD
en-wikipedia-org-4107	1715	35	be	be	VB
en-wikipedia-org-4107	1715	36	related	relate	VBN
en-wikipedia-org-4107	1715	37	to	to	IN
en-wikipedia-org-4107	1715	38	the	the	DT
en-wikipedia-org-4107	1715	39	activation	activation	NN
en-wikipedia-org-4107	1715	40	of	of	IN
en-wikipedia-org-4107	1715	41	these	these	DT
en-wikipedia-org-4107	1715	42	enzymes	enzyme	NNS
en-wikipedia-org-4107	1715	43	.	.	.
en-wikipedia-org-4107	1716	1	...	...	NFP
en-wikipedia-org-4107	1716	2	CAAs	CAAs	NNP
en-wikipedia-org-4107	1716	3	started	start	VBD
en-wikipedia-org-4107	1716	4	to	to	TO
en-wikipedia-org-4107	1716	5	be	be	VB
en-wikipedia-org-4107	1716	6	considered	consider	VBN
en-wikipedia-org-4107	1716	7	only	only	RB
en-wikipedia-org-4107	1716	8	recently	recently	RB
en-wikipedia-org-4107	1716	9	for	for	IN
en-wikipedia-org-4107	1716	10	possible	possible	JJ
en-wikipedia-org-4107	1716	11	pharmacologic	pharmacologic	NN
en-wikipedia-org-4107	1716	12	applications	application	NNS
en-wikipedia-org-4107	1716	13	in	in	IN
en-wikipedia-org-4107	1716	14	memory	memory	NN
en-wikipedia-org-4107	1716	15	/	/	SYM
en-wikipedia-org-4107	1716	16	cognition	cognition	NN
en-wikipedia-org-4107	1716	17	therapy27	therapy27	,
en-wikipedia-org-4107	1716	18	.	.	.
en-wikipedia-org-4107	1717	1	This	this	DT
en-wikipedia-org-4107	1717	2	work	work	NN
en-wikipedia-org-4107	1717	3	may	may	MD
en-wikipedia-org-4107	1717	4	bring	bring	VB
en-wikipedia-org-4107	1717	5	new	new	JJ
en-wikipedia-org-4107	1717	6	lights	light	NNS
en-wikipedia-org-4107	1717	7	on	on	IN
en-wikipedia-org-4107	1717	8	the	the	DT
en-wikipedia-org-4107	1717	9	intricate	intricate	JJ
en-wikipedia-org-4107	1717	10	relationship	relationship	NN
en-wikipedia-org-4107	1717	11	between	between	IN
en-wikipedia-org-4107	1717	12	CA	CA	NNP
en-wikipedia-org-4107	1717	13	activation	activation	NN
en-wikipedia-org-4107	1717	14	by	by	IN
en-wikipedia-org-4107	1717	15	this	this	DT
en-wikipedia-org-4107	1717	16	type	type	NN
en-wikipedia-org-4107	1717	17	of	of	IN
en-wikipedia-org-4107	1717	18	compounds	compound	NNS
en-wikipedia-org-4107	1717	19	and	and	CC
en-wikipedia-org-4107	1717	20	the	the	DT
en-wikipedia-org-4107	1717	21	multitude	multitude	NN
en-wikipedia-org-4107	1717	22	of	of	IN
en-wikipedia-org-4107	1717	23	pharmacologic	pharmacologic	JJ
en-wikipedia-org-4107	1717	24	actions	action	NNS
en-wikipedia-org-4107	1717	25	that	that	WDT
en-wikipedia-org-4107	1717	26	they	-PRON-	PRP
en-wikipedia-org-4107	1717	27	can	can	MD
en-wikipedia-org-4107	1717	28	elicit	elicit	VB
en-wikipedia-org-4107	1717	29	.	.	.
en-wikipedia-org-4107	1718	1	Table	table	NN
en-wikipedia-org-4107	1718	2	1	1	CD
en-wikipedia-org-4107	1718	3	:	:	:
en-wikipedia-org-4107	1718	4	CA	CA	NNP
en-wikipedia-org-4107	1718	5	activation	activation	NN
en-wikipedia-org-4107	1718	6	of	of	IN
en-wikipedia-org-4107	1718	7	isoforms	isoform	NNS
en-wikipedia-org-4107	1718	8	hCA	hca	VBP
en-wikipedia-org-4107	1718	9	I	-PRON-	PRP
en-wikipedia-org-4107	1718	10	,	,	,
en-wikipedia-org-4107	1718	11	II	II	NNP
en-wikipedia-org-4107	1718	12	,	,	,
en-wikipedia-org-4107	1718	13	IV	IV	NNP
en-wikipedia-org-4107	1718	14	,	,	,
en-wikipedia-org-4107	1718	15	VII	VII	NNP
en-wikipedia-org-4107	1718	16	,	,	,
en-wikipedia-org-4107	1718	17	and	and	CC
en-wikipedia-org-4107	1718	18	XIII	XIII	NNP
en-wikipedia-org-4107	1718	19	[	[	-LRB-
en-wikipedia-org-4107	1718	20	5	5	CD
en-wikipedia-org-4107	1718	21	:	:	:
en-wikipedia-org-4107	1718	22	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1718	23	]	]	-RRB-
en-wikipedia-org-4107	1718	24	Table	table	NN
en-wikipedia-org-4107	1718	25	2	2	CD
en-wikipedia-org-4107	1718	26	:	:	:
en-wikipedia-org-4107	1718	27	CA	CA	NNP
en-wikipedia-org-4107	1718	28	activation	activation	NN
en-wikipedia-org-4107	1718	29	of	of	IN
en-wikipedia-org-4107	1718	30	isoforms	isoform	NNS
en-wikipedia-org-4107	1718	31	hCA	hCA	VBD
en-wikipedia-org-4107	1718	32	VA	VA	NNP
en-wikipedia-org-4107	1718	33	,	,	,
en-wikipedia-org-4107	1718	34	VB	VB	NNP
en-wikipedia-org-4107	1718	35	,	,	,
en-wikipedia-org-4107	1718	36	VI	VI	NNP
en-wikipedia-org-4107	1718	37	,	,	,
en-wikipedia-org-4107	1718	38	IX	IX	NNP
en-wikipedia-org-4107	1718	39	,	,	,
en-wikipedia-org-4107	1718	40	XII	XII	NNP
en-wikipedia-org-4107	1718	41	,	,	,
en-wikipedia-org-4107	1718	42	and	and	CC
en-wikipedia-org-4107	1718	43	XIV	XIV	NNP
en-wikipedia-org-4107	1718	44	[	[	-LRB-
en-wikipedia-org-4107	1718	45	5	5	CD
en-wikipedia-org-4107	1718	46	:	:	:
en-wikipedia-org-4107	1718	47	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1718	48	]	]	-RRB-
en-wikipedia-org-4107	1718	49	^	^	FW
en-wikipedia-org-4107	1718	50	a	a	DT
en-wikipedia-org-4107	1718	51	b	b	NN
en-wikipedia-org-4107	1718	52	Lewin	Lewin	NNP
en-wikipedia-org-4107	1718	53	AH	AH	NNP
en-wikipedia-org-4107	1718	54	,	,	,
en-wikipedia-org-4107	1718	55	Miller	Miller	NNP
en-wikipedia-org-4107	1718	56	GM	GM	NNP
en-wikipedia-org-4107	1718	57	,	,	,
en-wikipedia-org-4107	1718	58	Gilmour	Gilmour	NNP
en-wikipedia-org-4107	1718	59	B	B	NNP
en-wikipedia-org-4107	1718	60	(	(	-LRB-
en-wikipedia-org-4107	1718	61	December	December	NNP
en-wikipedia-org-4107	1718	62	2011	2011	CD
en-wikipedia-org-4107	1718	63	)	)	-RRB-
en-wikipedia-org-4107	1718	64	.	.	.
en-wikipedia-org-4107	1719	1	"	"	``
en-wikipedia-org-4107	1719	2	Trace	trace	NN
en-wikipedia-org-4107	1719	3	amine	amine	NN
en-wikipedia-org-4107	1719	4	-	-	HYPH
en-wikipedia-org-4107	1719	5	associated	associate	VBN
en-wikipedia-org-4107	1719	6	receptor	receptor	NN
en-wikipedia-org-4107	1719	7	1	1	CD
en-wikipedia-org-4107	1719	8	is	be	VBZ
en-wikipedia-org-4107	1719	9	a	a	DT
en-wikipedia-org-4107	1719	10	stereoselective	stereoselective	JJ
en-wikipedia-org-4107	1719	11	binding	bind	VBG
en-wikipedia-org-4107	1719	12	site	site	NN
en-wikipedia-org-4107	1719	13	for	for	IN
en-wikipedia-org-4107	1719	14	compounds	compound	NNS
en-wikipedia-org-4107	1719	15	in	in	IN
en-wikipedia-org-4107	1719	16	the	the	DT
en-wikipedia-org-4107	1719	17	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1719	18	class	class	NN
en-wikipedia-org-4107	1719	19	"	"	''
en-wikipedia-org-4107	1719	20	.	.	.
en-wikipedia-org-4107	1720	1	Bioorganic	Bioorganic	NNP
en-wikipedia-org-4107	1720	2	&	&	CC
en-wikipedia-org-4107	1720	3	Medicinal	Medicinal	NNP
en-wikipedia-org-4107	1720	4	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	1720	5	.	.	.
en-wikipedia-org-4107	1721	1	19	19	CD
en-wikipedia-org-4107	1721	2	(	(	-LRB-
en-wikipedia-org-4107	1721	3	23	23	CD
en-wikipedia-org-4107	1721	4	)	)	-RRB-
en-wikipedia-org-4107	1721	5	:	:	:
en-wikipedia-org-4107	1721	6	7044–7048	7044–7048	ADD
en-wikipedia-org-4107	1721	7	.	.	.
en-wikipedia-org-4107	1722	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1722	2	/	/	SYM
en-wikipedia-org-4107	1722	3	j.bmc.2011.10.007	j.bmc.2011.10.007	JJ
en-wikipedia-org-4107	1722	4	.	.	.
en-wikipedia-org-4107	1723	1	PMC	PMC	NNP
en-wikipedia-org-4107	1723	2	 	  	_SP
en-wikipedia-org-4107	1723	3	3236098	3236098	CD
en-wikipedia-org-4107	1723	4	.	.	.
en-wikipedia-org-4107	1724	1	PMID	PMID	NNP
en-wikipedia-org-4107	1724	2	 	  	_SP
en-wikipedia-org-4107	1724	3	22037049	22037049	CD
en-wikipedia-org-4107	1724	4	.	.	.
en-wikipedia-org-4107	1725	1	^	^	NNP
en-wikipedia-org-4107	1725	2	a	a	DT
en-wikipedia-org-4107	1725	3	b	b	NN
en-wikipedia-org-4107	1725	4	Maguire	Maguire	NNP
en-wikipedia-org-4107	1725	5	JJ	JJ	NNP
en-wikipedia-org-4107	1725	6	,	,	,
en-wikipedia-org-4107	1725	7	Parker	Parker	NNP
en-wikipedia-org-4107	1725	8	WA	WA	NNP
en-wikipedia-org-4107	1725	9	,	,	,
en-wikipedia-org-4107	1725	10	Foord	Foord	NNP
en-wikipedia-org-4107	1725	11	SM	SM	NNP
en-wikipedia-org-4107	1725	12	,	,	,
en-wikipedia-org-4107	1725	13	Bonner	Bonner	NNP
en-wikipedia-org-4107	1725	14	TI	TI	NNP
en-wikipedia-org-4107	1725	15	,	,	,
en-wikipedia-org-4107	1725	16	Neubig	Neubig	NNP
en-wikipedia-org-4107	1725	17	RR	RR	NNP
en-wikipedia-org-4107	1725	18	,	,	,
en-wikipedia-org-4107	1725	19	Davenport	Davenport	NNP
en-wikipedia-org-4107	1725	20	AP	AP	NNP
en-wikipedia-org-4107	1725	21	(	(	-LRB-
en-wikipedia-org-4107	1725	22	March	March	NNP
en-wikipedia-org-4107	1725	23	2009	2009	CD
en-wikipedia-org-4107	1725	24	)	)	-RRB-
en-wikipedia-org-4107	1725	25	.	.	.
en-wikipedia-org-4107	1726	1	"	"	``
en-wikipedia-org-4107	1726	2	International	International	NNP
en-wikipedia-org-4107	1726	3	Union	Union	NNP
en-wikipedia-org-4107	1726	4	of	of	IN
en-wikipedia-org-4107	1726	5	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1726	6	.	.	.
en-wikipedia-org-4107	1727	1	LXXII	LXXII	NNP
en-wikipedia-org-4107	1727	2	.	.	.
en-wikipedia-org-4107	1728	1	Recommendations	recommendation	NNS
en-wikipedia-org-4107	1728	2	for	for	IN
en-wikipedia-org-4107	1728	3	trace	trace	NN
en-wikipedia-org-4107	1728	4	amine	amine	NN
en-wikipedia-org-4107	1728	5	receptor	receptor	NN
en-wikipedia-org-4107	1728	6	nomenclature	nomenclature	NN
en-wikipedia-org-4107	1728	7	"	"	''
en-wikipedia-org-4107	1728	8	.	.	.
en-wikipedia-org-4107	1729	1	Pharmacological	Pharmacological	NNP
en-wikipedia-org-4107	1729	2	Reviews	Reviews	NNPS
en-wikipedia-org-4107	1729	3	.	.	.
en-wikipedia-org-4107	1730	1	61	61	CD
en-wikipedia-org-4107	1730	2	(	(	-LRB-
en-wikipedia-org-4107	1730	3	1	1	CD
en-wikipedia-org-4107	1730	4	)	)	-RRB-
en-wikipedia-org-4107	1730	5	:	:	:
en-wikipedia-org-4107	1730	6	1–8	1–8	CD
en-wikipedia-org-4107	1730	7	.	.	.
en-wikipedia-org-4107	1731	1	doi:10.1124	doi:10.1124	NNP
en-wikipedia-org-4107	1731	2	/	/	SYM
en-wikipedia-org-4107	1731	3	pr.109.001107	pr.109.001107	NNP
en-wikipedia-org-4107	1731	4	.	.	.
en-wikipedia-org-4107	1732	1	PMC	PMC	NNP
en-wikipedia-org-4107	1732	2	 	  	_SP
en-wikipedia-org-4107	1732	3	2830119	2830119	CD
en-wikipedia-org-4107	1732	4	.	.	.
en-wikipedia-org-4107	1733	1	PMID	PMID	NNP
en-wikipedia-org-4107	1733	2	 	  	_SP
en-wikipedia-org-4107	1733	3	19325074	19325074	CD
en-wikipedia-org-4107	1733	4	.	.	.
en-wikipedia-org-4107	1734	1	^	^	NFP
en-wikipedia-org-4107	1734	2	Revel	Revel	NNP
en-wikipedia-org-4107	1734	3	FG	FG	NNP
en-wikipedia-org-4107	1734	4	,	,	,
en-wikipedia-org-4107	1734	5	Moreau	Moreau	NNP
en-wikipedia-org-4107	1734	6	JL	JL	NNP
en-wikipedia-org-4107	1734	7	,	,	,
en-wikipedia-org-4107	1734	8	Gainetdinov	Gainetdinov	NNP
en-wikipedia-org-4107	1734	9	RR	RR	NNP
en-wikipedia-org-4107	1734	10	,	,	,
en-wikipedia-org-4107	1734	11	Bradaia	Bradaia	NNP
en-wikipedia-org-4107	1734	12	A	A	NNP
en-wikipedia-org-4107	1734	13	,	,	,
en-wikipedia-org-4107	1734	14	Sotnikova	Sotnikova	NNP
en-wikipedia-org-4107	1734	15	TD	TD	NNP
en-wikipedia-org-4107	1734	16	,	,	,
en-wikipedia-org-4107	1734	17	Mory	Mory	NNP
en-wikipedia-org-4107	1734	18	R	R	NNP
en-wikipedia-org-4107	1734	19	,	,	,
en-wikipedia-org-4107	1734	20	Durkin	Durkin	NNP
en-wikipedia-org-4107	1734	21	S	S	NNP
en-wikipedia-org-4107	1734	22	,	,	,
en-wikipedia-org-4107	1734	23	Zbinden	Zbinden	NNP
en-wikipedia-org-4107	1734	24	KG	KG	NNP
en-wikipedia-org-4107	1734	25	,	,	,
en-wikipedia-org-4107	1734	26	Norcross	Norcross	NNP
en-wikipedia-org-4107	1734	27	R	R	NNP
en-wikipedia-org-4107	1734	28	,	,	,
en-wikipedia-org-4107	1734	29	Meyer	Meyer	NNP
en-wikipedia-org-4107	1734	30	CA	CA	NNP
en-wikipedia-org-4107	1734	31	,	,	,
en-wikipedia-org-4107	1734	32	Metzler	Metzler	NNP
en-wikipedia-org-4107	1734	33	V	V	NNP
en-wikipedia-org-4107	1734	34	,	,	,
en-wikipedia-org-4107	1734	35	Chaboz	Chaboz	NNP
en-wikipedia-org-4107	1734	36	S	S	NNP
en-wikipedia-org-4107	1734	37	,	,	,
en-wikipedia-org-4107	1734	38	Ozmen	Ozmen	NNP
en-wikipedia-org-4107	1734	39	L	L	NNP
en-wikipedia-org-4107	1734	40	,	,	,
en-wikipedia-org-4107	1734	41	Trube	Trube	NNP
en-wikipedia-org-4107	1734	42	G	G	NNP
en-wikipedia-org-4107	1734	43	,	,	,
en-wikipedia-org-4107	1734	44	Pouzet	Pouzet	NNP
en-wikipedia-org-4107	1734	45	B	B	NNP
en-wikipedia-org-4107	1734	46	,	,	,
en-wikipedia-org-4107	1734	47	Bettler	Bettler	NNP
en-wikipedia-org-4107	1734	48	B	B	NNP
en-wikipedia-org-4107	1734	49	,	,	,
en-wikipedia-org-4107	1734	50	Caron	Caron	NNP
en-wikipedia-org-4107	1734	51	MG	MG	NNP
en-wikipedia-org-4107	1734	52	,	,	,
en-wikipedia-org-4107	1734	53	Wettstein	Wettstein	NNP
en-wikipedia-org-4107	1734	54	JG	JG	NNP
en-wikipedia-org-4107	1734	55	,	,	,
en-wikipedia-org-4107	1734	56	Hoener	Hoener	NNP
en-wikipedia-org-4107	1734	57	MC	MC	NNP
en-wikipedia-org-4107	1734	58	(	(	-LRB-
en-wikipedia-org-4107	1734	59	May	May	NNP
en-wikipedia-org-4107	1734	60	2011	2011	CD
en-wikipedia-org-4107	1734	61	)	)	-RRB-
en-wikipedia-org-4107	1734	62	.	.	.
en-wikipedia-org-4107	1735	1	"	"	``
en-wikipedia-org-4107	1735	2	TAAR1	TAAR1	NNP
en-wikipedia-org-4107	1735	3	activation	activation	NN
en-wikipedia-org-4107	1735	4	modulates	modulate	VBZ
en-wikipedia-org-4107	1735	5	monoaminergic	monoaminergic	NN
en-wikipedia-org-4107	1735	6	neurotransmission	neurotransmission	NN
en-wikipedia-org-4107	1735	7	,	,	,
en-wikipedia-org-4107	1735	8	preventing	prevent	VBG
en-wikipedia-org-4107	1735	9	hyperdopaminergic	hyperdopaminergic	JJ
en-wikipedia-org-4107	1735	10	and	and	CC
en-wikipedia-org-4107	1735	11	hypoglutamatergic	hypoglutamatergic	JJ
en-wikipedia-org-4107	1735	12	activity	activity	NN
en-wikipedia-org-4107	1735	13	"	"	''
en-wikipedia-org-4107	1735	14	.	.	.
en-wikipedia-org-4107	1736	1	Proceedings	proceeding	NNS
en-wikipedia-org-4107	1736	2	of	of	IN
en-wikipedia-org-4107	1736	3	the	the	DT
en-wikipedia-org-4107	1736	4	National	National	NNP
en-wikipedia-org-4107	1736	5	Academy	Academy	NNP
en-wikipedia-org-4107	1736	6	of	of	IN
en-wikipedia-org-4107	1736	7	Sciences	Sciences	NNPS
en-wikipedia-org-4107	1736	8	.	.	.
en-wikipedia-org-4107	1737	1	108	108	CD
en-wikipedia-org-4107	1737	2	(	(	-LRB-
en-wikipedia-org-4107	1737	3	20	20	CD
en-wikipedia-org-4107	1737	4	)	)	-RRB-
en-wikipedia-org-4107	1737	5	:	:	:
en-wikipedia-org-4107	1737	6	8485–8490	8485–8490	CD
en-wikipedia-org-4107	1737	7	.	.	.
en-wikipedia-org-4107	1738	1	doi:10.1073	doi:10.1073	NNP
en-wikipedia-org-4107	1738	2	/	/	SYM
en-wikipedia-org-4107	1738	3	pnas.1103029108	pnas.1103029108	NN
en-wikipedia-org-4107	1738	4	.	.	.
en-wikipedia-org-4107	1739	1	PMC	PMC	NNP
en-wikipedia-org-4107	1739	2	 	  	_SP
en-wikipedia-org-4107	1739	3	3101002	3101002	CD
en-wikipedia-org-4107	1739	4	.	.	.
en-wikipedia-org-4107	1740	1	PMID	PMID	NNP
en-wikipedia-org-4107	1740	2	 	  	_SP
en-wikipedia-org-4107	1740	3	21525407	21525407	CD
en-wikipedia-org-4107	1740	4	.	.	.
en-wikipedia-org-4107	1741	1	^	^	NNP
en-wikipedia-org-4107	1741	2	a	a	DT
en-wikipedia-org-4107	1741	3	b	b	NNP
en-wikipedia-org-4107	1741	4	"	"	``
en-wikipedia-org-4107	1741	5	Amphetamine	amphetamine	NN
en-wikipedia-org-4107	1741	6	:	:	:
en-wikipedia-org-4107	1741	7	Biological	biological	JJ
en-wikipedia-org-4107	1741	8	activity	activity	NN
en-wikipedia-org-4107	1741	9	"	"	''
en-wikipedia-org-4107	1741	10	.	.	.
en-wikipedia-org-4107	1742	1	IUPHAR	IUPHAR	NNP
en-wikipedia-org-4107	1742	2	/	/	SYM
en-wikipedia-org-4107	1742	3	BPS	BPS	NNP
en-wikipedia-org-4107	1742	4	Guide	Guide	NNP
en-wikipedia-org-4107	1742	5	to	to	IN
en-wikipedia-org-4107	1742	6	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1742	7	.	.	.
en-wikipedia-org-4107	1743	1	International	International	NNP
en-wikipedia-org-4107	1743	2	Union	Union	NNP
en-wikipedia-org-4107	1743	3	of	of	IN
en-wikipedia-org-4107	1743	4	Basic	Basic	NNP
en-wikipedia-org-4107	1743	5	and	and	CC
en-wikipedia-org-4107	1743	6	Clinical	Clinical	NNP
en-wikipedia-org-4107	1743	7	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1743	8	.	.	.
en-wikipedia-org-4107	1744	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1744	2	31	31	CD
en-wikipedia-org-4107	1744	3	December	December	NNP
en-wikipedia-org-4107	1744	4	2019	2019	CD
en-wikipedia-org-4107	1744	5	.	.	.
en-wikipedia-org-4107	1745	1	^	^	NNP
en-wikipedia-org-4107	1745	2	a	a	DT
en-wikipedia-org-4107	1745	3	b	b	NN
en-wikipedia-org-4107	1745	4	Bozdag	Bozdag	NNP
en-wikipedia-org-4107	1745	5	M	M	NNP
en-wikipedia-org-4107	1745	6	,	,	,
en-wikipedia-org-4107	1745	7	Altamimi	Altamimi	NNP
en-wikipedia-org-4107	1745	8	AA	AA	NNP
en-wikipedia-org-4107	1745	9	,	,	,
en-wikipedia-org-4107	1745	10	Vullo	Vullo	NNP
en-wikipedia-org-4107	1745	11	D	D	NNP
en-wikipedia-org-4107	1745	12	,	,	,
en-wikipedia-org-4107	1745	13	Supuran	Supuran	NNP
en-wikipedia-org-4107	1745	14	CT	CT	NNP
en-wikipedia-org-4107	1745	15	,	,	,
en-wikipedia-org-4107	1745	16	Carta	Carta	NNP
en-wikipedia-org-4107	1745	17	F	F	NNP
en-wikipedia-org-4107	1745	18	(	(	-LRB-
en-wikipedia-org-4107	1745	19	2019	2019	CD
en-wikipedia-org-4107	1745	20	)	)	-RRB-
en-wikipedia-org-4107	1745	21	.	.	.
en-wikipedia-org-4107	1746	1	"	"	``
en-wikipedia-org-4107	1746	2	State	state	NN
en-wikipedia-org-4107	1746	3	of	of	IN
en-wikipedia-org-4107	1746	4	the	the	DT
en-wikipedia-org-4107	1746	5	Art	art	NN
en-wikipedia-org-4107	1746	6	on	on	IN
en-wikipedia-org-4107	1746	7	Carbonic	Carbonic	NNP
en-wikipedia-org-4107	1746	8	Anhydrase	Anhydrase	NNP
en-wikipedia-org-4107	1746	9	Modulators	Modulators	NNP
en-wikipedia-org-4107	1746	10	for	for	IN
en-wikipedia-org-4107	1746	11	Biomedical	Biomedical	NNP
en-wikipedia-org-4107	1746	12	Purposes	Purposes	NNPS
en-wikipedia-org-4107	1746	13	"	"	''
en-wikipedia-org-4107	1746	14	.	.	.
en-wikipedia-org-4107	1747	1	Current	current	JJ
en-wikipedia-org-4107	1747	2	Medicinal	Medicinal	NNP
en-wikipedia-org-4107	1747	3	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	1747	4	.	.	.
en-wikipedia-org-4107	1748	1	26	26	CD
en-wikipedia-org-4107	1748	2	(	(	-LRB-
en-wikipedia-org-4107	1748	3	15	15	CD
en-wikipedia-org-4107	1748	4	)	)	-RRB-
en-wikipedia-org-4107	1748	5	:	:	:
en-wikipedia-org-4107	1748	6	2558–2573	2558–2573	CD
en-wikipedia-org-4107	1748	7	.	.	.
en-wikipedia-org-4107	1749	1	doi:10.2174/0929867325666180622120625	doi:10.2174/0929867325666180622120625	NNP
en-wikipedia-org-4107	1749	2	.	.	.
en-wikipedia-org-4107	1750	1	PMID	PMID	NNP
en-wikipedia-org-4107	1750	2	 	  	_SP
en-wikipedia-org-4107	1750	3	29932025	29932025	CD
en-wikipedia-org-4107	1750	4	.	.	.
en-wikipedia-org-4107	1751	1	CARBONIC	CARBONIC	NNP
en-wikipedia-org-4107	1751	2	ANHYDRASE	ANHYDRASE	NNP
en-wikipedia-org-4107	1751	3	INHIBITORS	INHIBITORS	NNP
en-wikipedia-org-4107	1751	4	(	(	-LRB-
en-wikipedia-org-4107	1751	5	CAIs	CAIs	NNP
en-wikipedia-org-4107	1751	6	)	)	-RRB-
en-wikipedia-org-4107	1751	7	.	.	.
en-wikipedia-org-4107	1752	1	The	the	DT
en-wikipedia-org-4107	1752	2	design	design	NN
en-wikipedia-org-4107	1752	3	and	and	CC
en-wikipedia-org-4107	1752	4	development	development	NN
en-wikipedia-org-4107	1752	5	of	of	IN
en-wikipedia-org-4107	1752	6	CAIs	cai	NNS
en-wikipedia-org-4107	1752	7	represent	represent	VBP
en-wikipedia-org-4107	1752	8	the	the	DT
en-wikipedia-org-4107	1752	9	most	most	JJS
en-wikipedia-org-4107	1752	10	prolific	prolific	JJ
en-wikipedia-org-4107	1752	11	area	area	NN
en-wikipedia-org-4107	1752	12	within	within	IN
en-wikipedia-org-4107	1752	13	the	the	DT
en-wikipedia-org-4107	1752	14	CA	CA	NNP
en-wikipedia-org-4107	1752	15	research	research	NN
en-wikipedia-org-4107	1752	16	field	field	NN
en-wikipedia-org-4107	1752	17	.	.	.
en-wikipedia-org-4107	1753	1	Since	since	IN
en-wikipedia-org-4107	1753	2	the	the	DT
en-wikipedia-org-4107	1753	3	introduction	introduction	NN
en-wikipedia-org-4107	1753	4	of	of	IN
en-wikipedia-org-4107	1753	5	CAIs	CAIs	NNPS
en-wikipedia-org-4107	1753	6	in	in	IN
en-wikipedia-org-4107	1753	7	the	the	DT
en-wikipedia-org-4107	1753	8	clinical	clinical	JJ
en-wikipedia-org-4107	1753	9	use	use	NN
en-wikipedia-org-4107	1753	10	in	in	IN
en-wikipedia-org-4107	1753	11	the	the	DT
en-wikipedia-org-4107	1753	12	40	40	CD
en-wikipedia-org-4107	1753	13	'	'	CD
en-wikipedia-org-4107	1753	14	,	,	,
en-wikipedia-org-4107	1753	15	they	-PRON-	PRP
en-wikipedia-org-4107	1753	16	still	still	RB
en-wikipedia-org-4107	1753	17	are	be	VBP
en-wikipedia-org-4107	1753	18	the	the	DT
en-wikipedia-org-4107	1753	19	first	first	JJ
en-wikipedia-org-4107	1753	20	choice	choice	NN
en-wikipedia-org-4107	1753	21	for	for	IN
en-wikipedia-org-4107	1753	22	the	the	DT
en-wikipedia-org-4107	1753	23	treatment	treatment	NN
en-wikipedia-org-4107	1753	24	of	of	IN
en-wikipedia-org-4107	1753	25	edema	edema	NNP
en-wikipedia-org-4107	1753	26	[	[	-LRB-
en-wikipedia-org-4107	1753	27	9	9	CD
en-wikipedia-org-4107	1753	28	]	]	-RRB-
en-wikipedia-org-4107	1753	29	,	,	,
en-wikipedia-org-4107	1753	30	altitude	altitude	NN
en-wikipedia-org-4107	1753	31	sickness	sickness	NN
en-wikipedia-org-4107	1753	32	[	[	-LRB-
en-wikipedia-org-4107	1753	33	9	9	CD
en-wikipedia-org-4107	1753	34	]	]	-RRB-
en-wikipedia-org-4107	1753	35	,	,	,
en-wikipedia-org-4107	1753	36	glaucoma	glaucoma	NN
en-wikipedia-org-4107	1753	37	[	[	-LRB-
en-wikipedia-org-4107	1753	38	7	7	CD
en-wikipedia-org-4107	1753	39	]	]	-RRB-
en-wikipedia-org-4107	1753	40	and	and	CC
en-wikipedia-org-4107	1753	41	epilepsy	epilepsy	NN
en-wikipedia-org-4107	1753	42	[	[	-LRB-
en-wikipedia-org-4107	1753	43	31	31	CD
en-wikipedia-org-4107	1753	44	]	]	-RRB-
en-wikipedia-org-4107	1753	45	.	.	.
en-wikipedia-org-4107	1754	1	...	...	:
en-wikipedia-org-4107	1754	2	CARBONIC	CARBONIC	NNP
en-wikipedia-org-4107	1754	3	ANHYDRASE	ANHYDRASE	NNP
en-wikipedia-org-4107	1754	4	ACTIVATORS	ACTIVATORS	NNP
en-wikipedia-org-4107	1754	5	(	(	-LRB-
en-wikipedia-org-4107	1754	6	CAAs	CAAs	NNP
en-wikipedia-org-4107	1754	7	)	)	-RRB-
en-wikipedia-org-4107	1754	8	 	  	_SP
en-wikipedia-org-4107	1754	9	...	...	:
en-wikipedia-org-4107	1755	1	The	the	DT
en-wikipedia-org-4107	1755	2	emerging	emerge	VBG
en-wikipedia-org-4107	1755	3	class	class	NN
en-wikipedia-org-4107	1755	4	of	of	IN
en-wikipedia-org-4107	1755	5	CAAs	CAAs	NNP
en-wikipedia-org-4107	1755	6	has	have	VBZ
en-wikipedia-org-4107	1755	7	recently	recently	RB
en-wikipedia-org-4107	1755	8	gained	gain	VBN
en-wikipedia-org-4107	1755	9	attraction	attraction	NN
en-wikipedia-org-4107	1755	10	as	as	IN
en-wikipedia-org-4107	1755	11	the	the	DT
en-wikipedia-org-4107	1755	12	enhancement	enhancement	NN
en-wikipedia-org-4107	1755	13	of	of	IN
en-wikipedia-org-4107	1755	14	the	the	DT
en-wikipedia-org-4107	1755	15	kinetic	kinetic	JJ
en-wikipedia-org-4107	1755	16	properties	property	NNS
en-wikipedia-org-4107	1755	17	in	in	IN
en-wikipedia-org-4107	1755	18	hCAs	hcas	NN
en-wikipedia-org-4107	1755	19	expressed	express	VBN
en-wikipedia-org-4107	1755	20	in	in	IN
en-wikipedia-org-4107	1755	21	the	the	DT
en-wikipedia-org-4107	1755	22	CNS	CNS	NNP
en-wikipedia-org-4107	1755	23	were	be	VBD
en-wikipedia-org-4107	1755	24	proved	prove	VBN
en-wikipedia-org-4107	1755	25	in	in	IN
en-wikipedia-org-4107	1755	26	animal	animal	NN
en-wikipedia-org-4107	1755	27	models	model	NNS
en-wikipedia-org-4107	1755	28	to	to	TO
en-wikipedia-org-4107	1755	29	be	be	VB
en-wikipedia-org-4107	1755	30	beneficial	beneficial	JJ
en-wikipedia-org-4107	1755	31	for	for	IN
en-wikipedia-org-4107	1755	32	the	the	DT
en-wikipedia-org-4107	1755	33	treatment	treatment	NN
en-wikipedia-org-4107	1755	34	of	of	IN
en-wikipedia-org-4107	1755	35	both	both	CC
en-wikipedia-org-4107	1755	36	cognitive	cognitive	JJ
en-wikipedia-org-4107	1755	37	and	and	CC
en-wikipedia-org-4107	1755	38	memory	memory	NN
en-wikipedia-org-4107	1755	39	impairments	impairment	NNS
en-wikipedia-org-4107	1755	40	.	.	.
en-wikipedia-org-4107	1756	1	Thus	thus	RB
en-wikipedia-org-4107	1756	2	,	,	,
en-wikipedia-org-4107	1756	3	CAAs	caa	NNS
en-wikipedia-org-4107	1756	4	have	have	VBP
en-wikipedia-org-4107	1756	5	enormous	enormous	JJ
en-wikipedia-org-4107	1756	6	potentiality	potentiality	NN
en-wikipedia-org-4107	1756	7	in	in	IN
en-wikipedia-org-4107	1756	8	medicinal	medicinal	JJ
en-wikipedia-org-4107	1756	9	chemistry	chemistry	NN
en-wikipedia-org-4107	1756	10	to	to	TO
en-wikipedia-org-4107	1756	11	be	be	VB
en-wikipedia-org-4107	1756	12	developed	develop	VBN
en-wikipedia-org-4107	1756	13	for	for	IN
en-wikipedia-org-4107	1756	14	the	the	DT
en-wikipedia-org-4107	1756	15	treatment	treatment	NN
en-wikipedia-org-4107	1756	16	of	of	IN
en-wikipedia-org-4107	1756	17	symptoms	symptom	NNS
en-wikipedia-org-4107	1756	18	associated	associate	VBN
en-wikipedia-org-4107	1756	19	to	to	IN
en-wikipedia-org-4107	1756	20	aging	age	VBG
en-wikipedia-org-4107	1756	21	,	,	,
en-wikipedia-org-4107	1756	22	trauma	trauma	NN
en-wikipedia-org-4107	1756	23	or	or	CC
en-wikipedia-org-4107	1756	24	deterioration	deterioration	NN
en-wikipedia-org-4107	1756	25	of	of	IN
en-wikipedia-org-4107	1756	26	the	the	DT
en-wikipedia-org-4107	1756	27	CNS	CNS	NNP
en-wikipedia-org-4107	1756	28	tissues	tissue	NNS
en-wikipedia-org-4107	1756	29	.	.	.
en-wikipedia-org-4107	1757	1	^	^	NNP
en-wikipedia-org-4107	1757	2	a	a	DT
en-wikipedia-org-4107	1757	3	b	b	NNP
en-wikipedia-org-4107	1757	4	c	c	NNP
en-wikipedia-org-4107	1757	5	d	d	NNP
en-wikipedia-org-4107	1757	6	e	e	NNP
en-wikipedia-org-4107	1757	7	f	f	NNP
en-wikipedia-org-4107	1757	8	"	"	``
en-wikipedia-org-4107	1757	9	Vyvanse-	Vyvanse-	NNP
en-wikipedia-org-4107	1757	10	lisdexamfetamine	lisdexamfetamine	NNP
en-wikipedia-org-4107	1757	11	dimesylate	dimesylate	NNP
en-wikipedia-org-4107	1757	12	capsule	capsule	NNP
en-wikipedia-org-4107	1757	13	Vyvanse-	Vyvanse-	NNP
en-wikipedia-org-4107	1757	14	lisdexamfetamine	lisdexamfetamine	NNP
en-wikipedia-org-4107	1757	15	dimesylate	dimesylate	NN
en-wikipedia-org-4107	1757	16	tablet	tablet	NN
en-wikipedia-org-4107	1757	17	,	,	,
en-wikipedia-org-4107	1757	18	chewable	chewable	JJ
en-wikipedia-org-4107	1757	19	"	"	''
en-wikipedia-org-4107	1757	20	.	.	.
en-wikipedia-org-4107	1758	1	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	1758	2	.	.	.
en-wikipedia-org-4107	1759	1	Shire	Shire	NNP
en-wikipedia-org-4107	1759	2	US	US	NNP
en-wikipedia-org-4107	1759	3	Inc.	Inc.	NNP
en-wikipedia-org-4107	1759	4	30	30	CD
en-wikipedia-org-4107	1759	5	October	October	NNP
en-wikipedia-org-4107	1759	6	2019	2019	CD
en-wikipedia-org-4107	1759	7	.	.	.
en-wikipedia-org-4107	1760	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1760	2	22	22	CD
en-wikipedia-org-4107	1760	3	December	December	NNP
en-wikipedia-org-4107	1760	4	2019	2019	CD
en-wikipedia-org-4107	1760	5	.	.	.
en-wikipedia-org-4107	1761	1	^	^	FW
en-wikipedia-org-4107	1761	2	"	"	``
en-wikipedia-org-4107	1761	3	Compound	Compound	NNP
en-wikipedia-org-4107	1761	4	Summary	Summary	NNP
en-wikipedia-org-4107	1761	5	"	"	''
en-wikipedia-org-4107	1761	6	.	.	.
en-wikipedia-org-4107	1762	1	p	p	LS
en-wikipedia-org-4107	1762	2	-	-	:
en-wikipedia-org-4107	1762	3	Hydroxyamphetamine	Hydroxyamphetamine	NNP
en-wikipedia-org-4107	1762	4	.	.	.
en-wikipedia-org-4107	1763	1	PubChem	PubChem	NNP
en-wikipedia-org-4107	1763	2	Compound	Compound	NNP
en-wikipedia-org-4107	1763	3	Database	Database	NNP
en-wikipedia-org-4107	1763	4	.	.	.
en-wikipedia-org-4107	1764	1	United	United	NNP
en-wikipedia-org-4107	1764	2	States	States	NNP
en-wikipedia-org-4107	1764	3	National	National	NNP
en-wikipedia-org-4107	1764	4	Library	Library	NNP
en-wikipedia-org-4107	1764	5	of	of	IN
en-wikipedia-org-4107	1764	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	1764	7	 	  	_SP
en-wikipedia-org-4107	1764	8	–	–	:
en-wikipedia-org-4107	1764	9	National	National	NNP
en-wikipedia-org-4107	1764	10	Center	Center	NNP
en-wikipedia-org-4107	1764	11	for	for	IN
en-wikipedia-org-4107	1764	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	1764	13	Information	Information	NNP
en-wikipedia-org-4107	1764	14	.	.	.
en-wikipedia-org-4107	1765	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1765	2	15	15	CD
en-wikipedia-org-4107	1765	3	October	October	NNP
en-wikipedia-org-4107	1765	4	2013	2013	CD
en-wikipedia-org-4107	1765	5	.	.	.
en-wikipedia-org-4107	1766	1	^	^	FW
en-wikipedia-org-4107	1766	2	"	"	``
en-wikipedia-org-4107	1766	3	Compound	Compound	NNP
en-wikipedia-org-4107	1766	4	Summary	Summary	NNP
en-wikipedia-org-4107	1766	5	"	"	''
en-wikipedia-org-4107	1766	6	.	.	.
en-wikipedia-org-4107	1767	1	p	p	LS
en-wikipedia-org-4107	1767	2	-	-	:
en-wikipedia-org-4107	1767	3	Hydroxynorephedrine	Hydroxynorephedrine	NNP
en-wikipedia-org-4107	1767	4	.	.	.
en-wikipedia-org-4107	1768	1	PubChem	PubChem	NNP
en-wikipedia-org-4107	1768	2	Compound	Compound	NNP
en-wikipedia-org-4107	1768	3	Database	Database	NNP
en-wikipedia-org-4107	1768	4	.	.	.
en-wikipedia-org-4107	1769	1	United	United	NNP
en-wikipedia-org-4107	1769	2	States	States	NNP
en-wikipedia-org-4107	1769	3	National	National	NNP
en-wikipedia-org-4107	1769	4	Library	Library	NNP
en-wikipedia-org-4107	1769	5	of	of	IN
en-wikipedia-org-4107	1769	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	1769	7	 	  	_SP
en-wikipedia-org-4107	1769	8	–	–	:
en-wikipedia-org-4107	1769	9	National	National	NNP
en-wikipedia-org-4107	1769	10	Center	Center	NNP
en-wikipedia-org-4107	1769	11	for	for	IN
en-wikipedia-org-4107	1769	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	1769	13	Information	Information	NNP
en-wikipedia-org-4107	1769	14	.	.	.
en-wikipedia-org-4107	1770	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1770	2	15	15	CD
en-wikipedia-org-4107	1770	3	October	October	NNP
en-wikipedia-org-4107	1770	4	2013	2013	CD
en-wikipedia-org-4107	1770	5	.	.	.
en-wikipedia-org-4107	1771	1	^	^	FW
en-wikipedia-org-4107	1771	2	"	"	``
en-wikipedia-org-4107	1771	3	Compound	Compound	NNP
en-wikipedia-org-4107	1771	4	Summary	Summary	NNP
en-wikipedia-org-4107	1771	5	"	"	''
en-wikipedia-org-4107	1771	6	.	.	.
en-wikipedia-org-4107	1772	1	Phenylpropanolamine	Phenylpropanolamine	NNP
en-wikipedia-org-4107	1772	2	.	.	.
en-wikipedia-org-4107	1773	1	PubChem	PubChem	NNP
en-wikipedia-org-4107	1773	2	Compound	Compound	NNP
en-wikipedia-org-4107	1773	3	Database	Database	NNP
en-wikipedia-org-4107	1773	4	.	.	.
en-wikipedia-org-4107	1774	1	United	United	NNP
en-wikipedia-org-4107	1774	2	States	States	NNP
en-wikipedia-org-4107	1774	3	National	National	NNP
en-wikipedia-org-4107	1774	4	Library	Library	NNP
en-wikipedia-org-4107	1774	5	of	of	IN
en-wikipedia-org-4107	1774	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	1774	7	 	  	_SP
en-wikipedia-org-4107	1774	8	–	–	:
en-wikipedia-org-4107	1774	9	National	National	NNP
en-wikipedia-org-4107	1774	10	Center	Center	NNP
en-wikipedia-org-4107	1774	11	for	for	IN
en-wikipedia-org-4107	1774	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	1774	13	Information	Information	NNP
en-wikipedia-org-4107	1774	14	.	.	.
en-wikipedia-org-4107	1775	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1775	2	15	15	CD
en-wikipedia-org-4107	1775	3	October	October	NNP
en-wikipedia-org-4107	1775	4	2013	2013	CD
en-wikipedia-org-4107	1775	5	.	.	.
en-wikipedia-org-4107	1776	1	^	^	FW
en-wikipedia-org-4107	1776	2	"	"	``
en-wikipedia-org-4107	1776	3	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1776	4	and	and	CC
en-wikipedia-org-4107	1776	5	Biochemistry	Biochemistry	NNP
en-wikipedia-org-4107	1776	6	"	"	''
en-wikipedia-org-4107	1776	7	.	.	.
en-wikipedia-org-4107	1777	1	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1777	2	.	.	.
en-wikipedia-org-4107	1778	1	Pubchem	Pubchem	NNP
en-wikipedia-org-4107	1778	2	Compound	Compound	NNP
en-wikipedia-org-4107	1778	3	Database	Database	NNP
en-wikipedia-org-4107	1778	4	.	.	.
en-wikipedia-org-4107	1779	1	United	United	NNP
en-wikipedia-org-4107	1779	2	States	States	NNP
en-wikipedia-org-4107	1779	3	National	National	NNP
en-wikipedia-org-4107	1779	4	Library	Library	NNP
en-wikipedia-org-4107	1779	5	of	of	IN
en-wikipedia-org-4107	1779	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	1779	7	 	  	_SP
en-wikipedia-org-4107	1779	8	–	–	:
en-wikipedia-org-4107	1779	9	National	National	NNP
en-wikipedia-org-4107	1779	10	Center	Center	NNP
en-wikipedia-org-4107	1779	11	for	for	IN
en-wikipedia-org-4107	1779	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	1779	13	Information	Information	NNP
en-wikipedia-org-4107	1779	14	.	.	.
en-wikipedia-org-4107	1780	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1780	2	12	12	CD
en-wikipedia-org-4107	1780	3	October	October	NNP
en-wikipedia-org-4107	1780	4	2013	2013	CD
en-wikipedia-org-4107	1780	5	.	.	.
en-wikipedia-org-4107	1781	1	^	^	NNP
en-wikipedia-org-4107	1781	2	a	a	DT
en-wikipedia-org-4107	1781	3	b	b	NNP
en-wikipedia-org-4107	1781	4	c	c	NN
en-wikipedia-org-4107	1781	5	Sjoerdsma	Sjoerdsma	NNP
en-wikipedia-org-4107	1781	6	A	A	NNP
en-wikipedia-org-4107	1781	7	,	,	,
en-wikipedia-org-4107	1781	8	von	von	NNP
en-wikipedia-org-4107	1781	9	Studnitz	Studnitz	NNP
en-wikipedia-org-4107	1781	10	W	W	NNP
en-wikipedia-org-4107	1781	11	(	(	-LRB-
en-wikipedia-org-4107	1781	12	April	April	NNP
en-wikipedia-org-4107	1781	13	1963	1963	CD
en-wikipedia-org-4107	1781	14	)	)	-RRB-
en-wikipedia-org-4107	1781	15	.	.	.
en-wikipedia-org-4107	1782	1	"	"	``
en-wikipedia-org-4107	1782	2	Dopamine	dopamine	NN
en-wikipedia-org-4107	1782	3	-	-	HYPH
en-wikipedia-org-4107	1782	4	beta	beta	NN
en-wikipedia-org-4107	1782	5	-	-	HYPH
en-wikipedia-org-4107	1782	6	oxidase	oxidase	NN
en-wikipedia-org-4107	1782	7	activity	activity	NN
en-wikipedia-org-4107	1782	8	in	in	IN
en-wikipedia-org-4107	1782	9	man	man	NN
en-wikipedia-org-4107	1782	10	,	,	,
en-wikipedia-org-4107	1782	11	using	use	VBG
en-wikipedia-org-4107	1782	12	hydroxyamphetamine	hydroxyamphetamine	NN
en-wikipedia-org-4107	1782	13	as	as	IN
en-wikipedia-org-4107	1782	14	substrate	substrate	NN
en-wikipedia-org-4107	1782	15	"	"	''
en-wikipedia-org-4107	1782	16	.	.	.
en-wikipedia-org-4107	1783	1	British	British	NNP
en-wikipedia-org-4107	1783	2	Journal	Journal	NNP
en-wikipedia-org-4107	1783	3	of	of	IN
en-wikipedia-org-4107	1783	4	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1783	5	and	and	CC
en-wikipedia-org-4107	1783	6	Chemotherapy	Chemotherapy	NNP
en-wikipedia-org-4107	1783	7	.	.	.
en-wikipedia-org-4107	1784	1	20	20	CD
en-wikipedia-org-4107	1784	2	:	:	SYM
en-wikipedia-org-4107	1784	3	278–284	278–284	CD
en-wikipedia-org-4107	1784	4	.	.	.
en-wikipedia-org-4107	1785	1	doi:10.1111	doi:10.1111	NNP
en-wikipedia-org-4107	1785	2	/	/	SYM
en-wikipedia-org-4107	1785	3	j.1476	j.1476	NNP
en-wikipedia-org-4107	1785	4	-	-	HYPH
en-wikipedia-org-4107	1785	5	5381.1963.tb01467.x	5381.1963.tb01467.x	NNP
en-wikipedia-org-4107	1785	6	.	.	.
en-wikipedia-org-4107	1786	1	PMC	PMC	NNP
en-wikipedia-org-4107	1786	2	 	  	_SP
en-wikipedia-org-4107	1786	3	1703637	1703637	CD
en-wikipedia-org-4107	1786	4	.	.	.
en-wikipedia-org-4107	1787	1	PMID	PMID	NNP
en-wikipedia-org-4107	1787	2	 	  	_SP
en-wikipedia-org-4107	1787	3	13977820	13977820	CD
en-wikipedia-org-4107	1787	4	.	.	.
en-wikipedia-org-4107	1788	1	Hydroxyamphetamine	Hydroxyamphetamine	NNP
en-wikipedia-org-4107	1788	2	was	be	VBD
en-wikipedia-org-4107	1788	3	administered	administer	VBN
en-wikipedia-org-4107	1788	4	orally	orally	RB
en-wikipedia-org-4107	1788	5	to	to	IN
en-wikipedia-org-4107	1788	6	five	five	CD
en-wikipedia-org-4107	1788	7	human	human	JJ
en-wikipedia-org-4107	1788	8	subjects	subject	NNS
en-wikipedia-org-4107	1788	9	 	  	_SP
en-wikipedia-org-4107	1788	10	...	...	.
en-wikipedia-org-4107	1789	1	Since	since	IN
en-wikipedia-org-4107	1789	2	conversion	conversion	NN
en-wikipedia-org-4107	1789	3	of	of	IN
en-wikipedia-org-4107	1789	4	hydroxyamphetamine	hydroxyamphetamine	NN
en-wikipedia-org-4107	1789	5	to	to	TO
en-wikipedia-org-4107	1789	6	hydroxynorephedrine	hydroxynorephedrine	VB
en-wikipedia-org-4107	1789	7	occurs	occur	VBZ
en-wikipedia-org-4107	1789	8	in	in	IN
en-wikipedia-org-4107	1789	9	vitro	vitro	FW
en-wikipedia-org-4107	1789	10	by	by	IN
en-wikipedia-org-4107	1789	11	the	the	DT
en-wikipedia-org-4107	1789	12	action	action	NN
en-wikipedia-org-4107	1789	13	of	of	IN
en-wikipedia-org-4107	1789	14	dopamine	dopamine	NN
en-wikipedia-org-4107	1789	15	-	-	HYPH
en-wikipedia-org-4107	1789	16	β	β	NN
en-wikipedia-org-4107	1789	17	-	-	HYPH
en-wikipedia-org-4107	1789	18	oxidase	oxidase	NNP
en-wikipedia-org-4107	1789	19	,	,	,
en-wikipedia-org-4107	1789	20	a	a	DT
en-wikipedia-org-4107	1789	21	simple	simple	JJ
en-wikipedia-org-4107	1789	22	method	method	NN
en-wikipedia-org-4107	1789	23	is	be	VBZ
en-wikipedia-org-4107	1789	24	suggested	suggest	VBN
en-wikipedia-org-4107	1789	25	for	for	IN
en-wikipedia-org-4107	1789	26	measuring	measure	VBG
en-wikipedia-org-4107	1789	27	the	the	DT
en-wikipedia-org-4107	1789	28	activity	activity	NN
en-wikipedia-org-4107	1789	29	of	of	IN
en-wikipedia-org-4107	1789	30	this	this	DT
en-wikipedia-org-4107	1789	31	enzyme	enzyme	NNS
en-wikipedia-org-4107	1789	32	and	and	CC
en-wikipedia-org-4107	1789	33	the	the	DT
en-wikipedia-org-4107	1789	34	effect	effect	NN
en-wikipedia-org-4107	1789	35	of	of	IN
en-wikipedia-org-4107	1789	36	its	-PRON-	PRP$
en-wikipedia-org-4107	1789	37	inhibitors	inhibitor	NNS
en-wikipedia-org-4107	1789	38	in	in	IN
en-wikipedia-org-4107	1789	39	man	man	NN
en-wikipedia-org-4107	1789	40	.	.	.
en-wikipedia-org-4107	1790	1	...	...	NFP
en-wikipedia-org-4107	1791	1	The	the	DT
en-wikipedia-org-4107	1791	2	lack	lack	NN
en-wikipedia-org-4107	1791	3	of	of	IN
en-wikipedia-org-4107	1791	4	effect	effect	NN
en-wikipedia-org-4107	1791	5	of	of	IN
en-wikipedia-org-4107	1791	6	administration	administration	NN
en-wikipedia-org-4107	1791	7	of	of	IN
en-wikipedia-org-4107	1791	8	neomycin	neomycin	NNP
en-wikipedia-org-4107	1791	9	to	to	IN
en-wikipedia-org-4107	1791	10	one	one	CD
en-wikipedia-org-4107	1791	11	patient	patient	NN
en-wikipedia-org-4107	1791	12	indicates	indicate	VBZ
en-wikipedia-org-4107	1791	13	that	that	IN
en-wikipedia-org-4107	1791	14	the	the	DT
en-wikipedia-org-4107	1791	15	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	1791	16	occurs	occur	VBZ
en-wikipedia-org-4107	1791	17	in	in	IN
en-wikipedia-org-4107	1791	18	body	body	NN
en-wikipedia-org-4107	1791	19	tissues	tissue	NNS
en-wikipedia-org-4107	1791	20	.	.	.
en-wikipedia-org-4107	1792	1	...	...	:
en-wikipedia-org-4107	1792	2	a	a	DT
en-wikipedia-org-4107	1792	3	major	major	JJ
en-wikipedia-org-4107	1792	4	portion	portion	NN
en-wikipedia-org-4107	1792	5	of	of	IN
en-wikipedia-org-4107	1792	6	the	the	DT
en-wikipedia-org-4107	1792	7	β	β	NN
en-wikipedia-org-4107	1792	8	-	-	HYPH
en-wikipedia-org-4107	1792	9	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	1792	10	of	of	IN
en-wikipedia-org-4107	1792	11	hydroxyamphetamine	hydroxyamphetamine	NN
en-wikipedia-org-4107	1792	12	occurs	occur	VBZ
en-wikipedia-org-4107	1792	13	in	in	IN
en-wikipedia-org-4107	1792	14	non	non	JJ
en-wikipedia-org-4107	1792	15	-	-	JJ
en-wikipedia-org-4107	1792	16	adrenal	adrenal	JJ
en-wikipedia-org-4107	1792	17	tissue	tissue	NN
en-wikipedia-org-4107	1792	18	.	.	.
en-wikipedia-org-4107	1793	1	Unfortunately	unfortunately	RB
en-wikipedia-org-4107	1793	2	,	,	,
en-wikipedia-org-4107	1793	3	at	at	IN
en-wikipedia-org-4107	1793	4	the	the	DT
en-wikipedia-org-4107	1793	5	present	present	JJ
en-wikipedia-org-4107	1793	6	time	time	NN
en-wikipedia-org-4107	1793	7	one	one	PRP
en-wikipedia-org-4107	1793	8	can	can	MD
en-wikipedia-org-4107	1793	9	not	not	RB
en-wikipedia-org-4107	1793	10	be	be	VB
en-wikipedia-org-4107	1793	11	completely	completely	RB
en-wikipedia-org-4107	1793	12	certain	certain	JJ
en-wikipedia-org-4107	1793	13	that	that	IN
en-wikipedia-org-4107	1793	14	the	the	DT
en-wikipedia-org-4107	1793	15	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	1793	16	of	of	IN
en-wikipedia-org-4107	1793	17	hydroxyamphetamine	hydroxyamphetamine	NN
en-wikipedia-org-4107	1793	18	in	in	IN
en-wikipedia-org-4107	1793	19	vivo	vivo	NNP
en-wikipedia-org-4107	1793	20	is	be	VBZ
en-wikipedia-org-4107	1793	21	accomplished	accomplish	VBN
en-wikipedia-org-4107	1793	22	by	by	IN
en-wikipedia-org-4107	1793	23	the	the	DT
en-wikipedia-org-4107	1793	24	same	same	JJ
en-wikipedia-org-4107	1793	25	enzyme	enzyme	NNS
en-wikipedia-org-4107	1793	26	which	which	WDT
en-wikipedia-org-4107	1793	27	converts	convert	VBZ
en-wikipedia-org-4107	1793	28	dopamine	dopamine	NN
en-wikipedia-org-4107	1793	29	to	to	IN
en-wikipedia-org-4107	1793	30	noradrenaline	noradrenaline	NNP
en-wikipedia-org-4107	1793	31	.	.	.
en-wikipedia-org-4107	1794	1	^	^	NNP
en-wikipedia-org-4107	1794	2	a	a	DT
en-wikipedia-org-4107	1794	3	b	b	NN
en-wikipedia-org-4107	1794	4	Badenhorst	Badenhorst	NNP
en-wikipedia-org-4107	1794	5	CP	CP	NNP
en-wikipedia-org-4107	1794	6	,	,	,
en-wikipedia-org-4107	1794	7	van	van	NNP
en-wikipedia-org-4107	1794	8	der	der	NN
en-wikipedia-org-4107	1794	9	Sluis	Sluis	NNP
en-wikipedia-org-4107	1794	10	R	R	NNP
en-wikipedia-org-4107	1794	11	,	,	,
en-wikipedia-org-4107	1794	12	Erasmus	Erasmus	NNP
en-wikipedia-org-4107	1794	13	E	E	NNP
en-wikipedia-org-4107	1794	14	,	,	,
en-wikipedia-org-4107	1794	15	van	van	NNP
en-wikipedia-org-4107	1794	16	Dijk	Dijk	NNP
en-wikipedia-org-4107	1794	17	AA	AA	NNP
en-wikipedia-org-4107	1794	18	(	(	-LRB-
en-wikipedia-org-4107	1794	19	September	September	NNP
en-wikipedia-org-4107	1794	20	2013	2013	CD
en-wikipedia-org-4107	1794	21	)	)	-RRB-
en-wikipedia-org-4107	1794	22	.	.	.
en-wikipedia-org-4107	1795	1	"	"	``
en-wikipedia-org-4107	1795	2	Glycine	Glycine	NNP
en-wikipedia-org-4107	1795	3	conjugation	conjugation	NN
en-wikipedia-org-4107	1795	4	:	:	:
en-wikipedia-org-4107	1795	5	importance	importance	NN
en-wikipedia-org-4107	1795	6	in	in	IN
en-wikipedia-org-4107	1795	7	metabolism	metabolism	NN
en-wikipedia-org-4107	1795	8	,	,	,
en-wikipedia-org-4107	1795	9	the	the	DT
en-wikipedia-org-4107	1795	10	role	role	NN
en-wikipedia-org-4107	1795	11	of	of	IN
en-wikipedia-org-4107	1795	12	glycine	glycine	JJ
en-wikipedia-org-4107	1795	13	N	n	NN
en-wikipedia-org-4107	1795	14	-	-	HYPH
en-wikipedia-org-4107	1795	15	acyltransferase	acyltransferase	NN
en-wikipedia-org-4107	1795	16	,	,	,
en-wikipedia-org-4107	1795	17	and	and	CC
en-wikipedia-org-4107	1795	18	factors	factor	NNS
en-wikipedia-org-4107	1795	19	that	that	WDT
en-wikipedia-org-4107	1795	20	influence	influence	VBP
en-wikipedia-org-4107	1795	21	interindividual	interindividual	JJ
en-wikipedia-org-4107	1795	22	variation	variation	NN
en-wikipedia-org-4107	1795	23	"	"	''
en-wikipedia-org-4107	1795	24	.	.	.
en-wikipedia-org-4107	1796	1	Expert	Expert	NNP
en-wikipedia-org-4107	1796	2	Opinion	Opinion	NNP
en-wikipedia-org-4107	1796	3	on	on	IN
en-wikipedia-org-4107	1796	4	Drug	Drug	NNP
en-wikipedia-org-4107	1796	5	Metabolism	Metabolism	NNP
en-wikipedia-org-4107	1796	6	&	&	CC
en-wikipedia-org-4107	1796	7	Toxicology	Toxicology	NNP
en-wikipedia-org-4107	1796	8	.	.	.
en-wikipedia-org-4107	1797	1	9	9	CD
en-wikipedia-org-4107	1797	2	(	(	-LRB-
en-wikipedia-org-4107	1797	3	9	9	CD
en-wikipedia-org-4107	1797	4	)	)	-RRB-
en-wikipedia-org-4107	1797	5	:	:	:
en-wikipedia-org-4107	1797	6	1139–1153	1139–1153	CD
en-wikipedia-org-4107	1797	7	.	.	.
en-wikipedia-org-4107	1798	1	doi:10.1517/17425255.2013.796929	doi:10.1517/17425255.2013.796929	NNP
en-wikipedia-org-4107	1798	2	.	.	.
en-wikipedia-org-4107	1799	1	PMID	PMID	NNP
en-wikipedia-org-4107	1799	2	 	  	_SP
en-wikipedia-org-4107	1799	3	23650932	23650932	CD
en-wikipedia-org-4107	1799	4	.	.	.
en-wikipedia-org-4107	1800	1	Figure	figure	NN
en-wikipedia-org-4107	1800	2	1	1	CD
en-wikipedia-org-4107	1800	3	.	.	.
en-wikipedia-org-4107	1801	1	Glycine	glycine	JJ
en-wikipedia-org-4107	1801	2	conjugation	conjugation	NN
en-wikipedia-org-4107	1801	3	of	of	IN
en-wikipedia-org-4107	1801	4	benzoic	benzoic	JJ
en-wikipedia-org-4107	1801	5	acid	acid	NN
en-wikipedia-org-4107	1801	6	.	.	.
en-wikipedia-org-4107	1802	1	The	the	DT
en-wikipedia-org-4107	1802	2	glycine	glycine	JJ
en-wikipedia-org-4107	1802	3	conjugation	conjugation	NN
en-wikipedia-org-4107	1802	4	pathway	pathway	NN
en-wikipedia-org-4107	1802	5	consists	consist	VBZ
en-wikipedia-org-4107	1802	6	of	of	IN
en-wikipedia-org-4107	1802	7	two	two	CD
en-wikipedia-org-4107	1802	8	steps	step	NNS
en-wikipedia-org-4107	1802	9	.	.	.
en-wikipedia-org-4107	1803	1	First	first	JJ
en-wikipedia-org-4107	1803	2	benzoate	benzoate	NN
en-wikipedia-org-4107	1803	3	is	be	VBZ
en-wikipedia-org-4107	1803	4	ligated	ligate	VBN
en-wikipedia-org-4107	1803	5	to	to	IN
en-wikipedia-org-4107	1803	6	CoASH	CoASH	NNP
en-wikipedia-org-4107	1803	7	to	to	TO
en-wikipedia-org-4107	1803	8	form	form	VB
en-wikipedia-org-4107	1803	9	the	the	DT
en-wikipedia-org-4107	1803	10	high	high	JJ
en-wikipedia-org-4107	1803	11	-	-	HYPH
en-wikipedia-org-4107	1803	12	energy	energy	NN
en-wikipedia-org-4107	1803	13	benzoyl	benzoyl	NNP
en-wikipedia-org-4107	1803	14	-	-	HYPH
en-wikipedia-org-4107	1803	15	CoA	CoA	NNP
en-wikipedia-org-4107	1803	16	thioester	thioester	NN
en-wikipedia-org-4107	1803	17	.	.	.
en-wikipedia-org-4107	1804	1	This	this	DT
en-wikipedia-org-4107	1804	2	reaction	reaction	NN
en-wikipedia-org-4107	1804	3	is	be	VBZ
en-wikipedia-org-4107	1804	4	catalyzed	catalyze	VBN
en-wikipedia-org-4107	1804	5	by	by	IN
en-wikipedia-org-4107	1804	6	the	the	DT
en-wikipedia-org-4107	1804	7	HXM	HXM	NNP
en-wikipedia-org-4107	1804	8	-	-	HYPH
en-wikipedia-org-4107	1804	9	A	a	NN
en-wikipedia-org-4107	1804	10	and	and	CC
en-wikipedia-org-4107	1804	11	HXM	HXM	NNP
en-wikipedia-org-4107	1804	12	-	-	HYPH
en-wikipedia-org-4107	1804	13	B	b	NN
en-wikipedia-org-4107	1804	14	medium	medium	JJ
en-wikipedia-org-4107	1804	15	-	-	HYPH
en-wikipedia-org-4107	1804	16	chain	chain	NN
en-wikipedia-org-4107	1804	17	acid	acid	NN
en-wikipedia-org-4107	1804	18	:	:	:
en-wikipedia-org-4107	1804	19	CoA	CoA	NNP
en-wikipedia-org-4107	1804	20	ligases	ligase	VBZ
en-wikipedia-org-4107	1804	21	and	and	CC
en-wikipedia-org-4107	1804	22	requires	require	VBZ
en-wikipedia-org-4107	1804	23	energy	energy	NN
en-wikipedia-org-4107	1804	24	in	in	IN
en-wikipedia-org-4107	1804	25	the	the	DT
en-wikipedia-org-4107	1804	26	form	form	NN
en-wikipedia-org-4107	1804	27	of	of	IN
en-wikipedia-org-4107	1804	28	ATP	atp	NN
en-wikipedia-org-4107	1804	29	.	.	.
en-wikipedia-org-4107	1805	1	...	...	NFP
en-wikipedia-org-4107	1806	1	The	the	DT
en-wikipedia-org-4107	1806	2	benzoyl	benzoyl	NN
en-wikipedia-org-4107	1806	3	-	-	HYPH
en-wikipedia-org-4107	1806	4	CoA	CoA	NNP
en-wikipedia-org-4107	1806	5	is	be	VBZ
en-wikipedia-org-4107	1806	6	then	then	RB
en-wikipedia-org-4107	1806	7	conjugated	conjugate	VBN
en-wikipedia-org-4107	1806	8	to	to	IN
en-wikipedia-org-4107	1806	9	glycine	glycine	VB
en-wikipedia-org-4107	1806	10	by	by	IN
en-wikipedia-org-4107	1806	11	GLYAT	GLYAT	NNP
en-wikipedia-org-4107	1806	12	to	to	TO
en-wikipedia-org-4107	1806	13	form	form	VB
en-wikipedia-org-4107	1806	14	hippuric	hippuric	NN
en-wikipedia-org-4107	1806	15	acid	acid	NN
en-wikipedia-org-4107	1806	16	,	,	,
en-wikipedia-org-4107	1806	17	releasing	release	VBG
en-wikipedia-org-4107	1806	18	CoASH	CoASH	NNP
en-wikipedia-org-4107	1806	19	.	.	.
en-wikipedia-org-4107	1807	1	In	in	IN
en-wikipedia-org-4107	1807	2	addition	addition	NN
en-wikipedia-org-4107	1807	3	to	to	IN
en-wikipedia-org-4107	1807	4	the	the	DT
en-wikipedia-org-4107	1807	5	factors	factor	NNS
en-wikipedia-org-4107	1807	6	listed	list	VBN
en-wikipedia-org-4107	1807	7	in	in	IN
en-wikipedia-org-4107	1807	8	the	the	DT
en-wikipedia-org-4107	1807	9	boxes	box	NNS
en-wikipedia-org-4107	1807	10	,	,	,
en-wikipedia-org-4107	1807	11	the	the	DT
en-wikipedia-org-4107	1807	12	levels	level	NNS
en-wikipedia-org-4107	1807	13	of	of	IN
en-wikipedia-org-4107	1807	14	ATP	ATP	NNP
en-wikipedia-org-4107	1807	15	,	,	,
en-wikipedia-org-4107	1807	16	CoASH	CoASH	NNP
en-wikipedia-org-4107	1807	17	,	,	,
en-wikipedia-org-4107	1807	18	and	and	CC
en-wikipedia-org-4107	1807	19	glycine	glycine	NN
en-wikipedia-org-4107	1807	20	may	may	MD
en-wikipedia-org-4107	1807	21	influence	influence	VB
en-wikipedia-org-4107	1807	22	the	the	DT
en-wikipedia-org-4107	1807	23	overall	overall	JJ
en-wikipedia-org-4107	1807	24	rate	rate	NN
en-wikipedia-org-4107	1807	25	of	of	IN
en-wikipedia-org-4107	1807	26	the	the	DT
en-wikipedia-org-4107	1807	27	glycine	glycine	NNP
en-wikipedia-org-4107	1807	28	conjugation	conjugation	NNP
en-wikipedia-org-4107	1807	29	pathway	pathway	NNP
en-wikipedia-org-4107	1807	30	.	.	.
en-wikipedia-org-4107	1808	1	^	^	NN
en-wikipedia-org-4107	1808	2	Horwitz	Horwitz	NNP
en-wikipedia-org-4107	1808	3	D	D	NNP
en-wikipedia-org-4107	1808	4	,	,	,
en-wikipedia-org-4107	1808	5	Alexander	Alexander	NNP
en-wikipedia-org-4107	1808	6	RW	RW	NNP
en-wikipedia-org-4107	1808	7	,	,	,
en-wikipedia-org-4107	1808	8	Lovenberg	Lovenberg	NNP
en-wikipedia-org-4107	1808	9	W	W	NNP
en-wikipedia-org-4107	1808	10	,	,	,
en-wikipedia-org-4107	1808	11	Keiser	Keiser	NNP
en-wikipedia-org-4107	1808	12	HR	hr	NN
en-wikipedia-org-4107	1808	13	(	(	-LRB-
en-wikipedia-org-4107	1808	14	May	May	NNP
en-wikipedia-org-4107	1808	15	1973	1973	CD
en-wikipedia-org-4107	1808	16	)	)	-RRB-
en-wikipedia-org-4107	1808	17	.	.	.
en-wikipedia-org-4107	1809	1	"	"	``
en-wikipedia-org-4107	1809	2	Human	human	JJ
en-wikipedia-org-4107	1809	3	serum	serum	NN
en-wikipedia-org-4107	1809	4	dopamine	dopamine	NN
en-wikipedia-org-4107	1809	5	-	-	HYPH
en-wikipedia-org-4107	1809	6	β	β	NN
en-wikipedia-org-4107	1809	7	-	-	HYPH
en-wikipedia-org-4107	1809	8	hydroxylase	hydroxylase	NN
en-wikipedia-org-4107	1809	9	.	.	.
en-wikipedia-org-4107	1810	1	Relationship	relationship	NN
en-wikipedia-org-4107	1810	2	to	to	TO
en-wikipedia-org-4107	1810	3	hypertension	hypertension	NN
en-wikipedia-org-4107	1810	4	and	and	CC
en-wikipedia-org-4107	1810	5	sympathetic	sympathetic	JJ
en-wikipedia-org-4107	1810	6	activity	activity	NN
en-wikipedia-org-4107	1810	7	"	"	''
en-wikipedia-org-4107	1810	8	.	.	.
en-wikipedia-org-4107	1811	1	Circulation	Circulation	NNP
en-wikipedia-org-4107	1811	2	Research	Research	NNP
en-wikipedia-org-4107	1811	3	.	.	.
en-wikipedia-org-4107	1812	1	32	32	CD
en-wikipedia-org-4107	1812	2	(	(	-LRB-
en-wikipedia-org-4107	1812	3	5	5	CD
en-wikipedia-org-4107	1812	4	)	)	-RRB-
en-wikipedia-org-4107	1812	5	:	:	:
en-wikipedia-org-4107	1812	6	594–599	594–599	CD
en-wikipedia-org-4107	1812	7	.	.	.
en-wikipedia-org-4107	1813	1	doi:10.1161/01.RES.32.5.594	doi:10.1161/01.res.32.5.594	LS
en-wikipedia-org-4107	1813	2	.	.	.
en-wikipedia-org-4107	1814	1	PMID	PMID	NNP
en-wikipedia-org-4107	1814	2	 	  	_SP
en-wikipedia-org-4107	1814	3	4713201	4713201	CD
en-wikipedia-org-4107	1814	4	.	.	.
en-wikipedia-org-4107	1815	1	The	the	DT
en-wikipedia-org-4107	1815	2	biologic	biologic	JJ
en-wikipedia-org-4107	1815	3	significance	significance	NN
en-wikipedia-org-4107	1815	4	of	of	IN
en-wikipedia-org-4107	1815	5	the	the	DT
en-wikipedia-org-4107	1815	6	different	different	JJ
en-wikipedia-org-4107	1815	7	levels	level	NNS
en-wikipedia-org-4107	1815	8	of	of	IN
en-wikipedia-org-4107	1815	9	serum	serum	NNP
en-wikipedia-org-4107	1815	10	DβH	DβH	NNP
en-wikipedia-org-4107	1815	11	activity	activity	NN
en-wikipedia-org-4107	1815	12	was	be	VBD
en-wikipedia-org-4107	1815	13	studied	study	VBN
en-wikipedia-org-4107	1815	14	in	in	IN
en-wikipedia-org-4107	1815	15	two	two	CD
en-wikipedia-org-4107	1815	16	ways	way	NNS
en-wikipedia-org-4107	1815	17	.	.	.
en-wikipedia-org-4107	1816	1	First	first	RB
en-wikipedia-org-4107	1816	2	,	,	,
en-wikipedia-org-4107	1816	3	in	in	IN
en-wikipedia-org-4107	1816	4	vivo	vivo	NNP
en-wikipedia-org-4107	1816	5	ability	ability	NN
en-wikipedia-org-4107	1816	6	to	to	IN
en-wikipedia-org-4107	1816	7	β	β	NN
en-wikipedia-org-4107	1816	8	-	-	HYPH
en-wikipedia-org-4107	1816	9	hydroxylate	hydroxylate	VB
en-wikipedia-org-4107	1816	10	the	the	DT
en-wikipedia-org-4107	1816	11	synthetic	synthetic	JJ
en-wikipedia-org-4107	1816	12	substrate	substrate	NN
en-wikipedia-org-4107	1816	13	hydroxyamphetamine	hydroxyamphetamine	NN
en-wikipedia-org-4107	1816	14	was	be	VBD
en-wikipedia-org-4107	1816	15	compared	compare	VBN
en-wikipedia-org-4107	1816	16	in	in	IN
en-wikipedia-org-4107	1816	17	two	two	CD
en-wikipedia-org-4107	1816	18	subjects	subject	NNS
en-wikipedia-org-4107	1816	19	with	with	IN
en-wikipedia-org-4107	1816	20	low	low	JJ
en-wikipedia-org-4107	1816	21	serum	serum	NN
en-wikipedia-org-4107	1816	22	DβH	DβH	NNP
en-wikipedia-org-4107	1816	23	activity	activity	NN
en-wikipedia-org-4107	1816	24	and	and	CC
en-wikipedia-org-4107	1816	25	two	two	CD
en-wikipedia-org-4107	1816	26	subjects	subject	NNS
en-wikipedia-org-4107	1816	27	with	with	IN
en-wikipedia-org-4107	1816	28	average	average	JJ
en-wikipedia-org-4107	1816	29	activity	activity	NN
en-wikipedia-org-4107	1816	30	.	.	.
en-wikipedia-org-4107	1817	1	...	...	NFP
en-wikipedia-org-4107	1818	1	In	in	IN
en-wikipedia-org-4107	1818	2	one	one	CD
en-wikipedia-org-4107	1818	3	study	study	NN
en-wikipedia-org-4107	1818	4	,	,	,
en-wikipedia-org-4107	1818	5	hydroxyamphetamine	hydroxyamphetamine	NN
en-wikipedia-org-4107	1818	6	(	(	-LRB-
en-wikipedia-org-4107	1818	7	Paredrine	Paredrine	NNP
en-wikipedia-org-4107	1818	8	)	)	-RRB-
en-wikipedia-org-4107	1818	9	,	,	,
en-wikipedia-org-4107	1818	10	a	a	DT
en-wikipedia-org-4107	1818	11	synthetic	synthetic	JJ
en-wikipedia-org-4107	1818	12	substrate	substrate	NN
en-wikipedia-org-4107	1818	13	for	for	IN
en-wikipedia-org-4107	1818	14	DβH	DβH	NNP
en-wikipedia-org-4107	1818	15	,	,	,
en-wikipedia-org-4107	1818	16	was	be	VBD
en-wikipedia-org-4107	1818	17	administered	administer	VBN
en-wikipedia-org-4107	1818	18	to	to	IN
en-wikipedia-org-4107	1818	19	subjects	subject	NNS
en-wikipedia-org-4107	1818	20	with	with	IN
en-wikipedia-org-4107	1818	21	either	either	CC
en-wikipedia-org-4107	1818	22	low	low	JJ
en-wikipedia-org-4107	1818	23	or	or	CC
en-wikipedia-org-4107	1818	24	average	average	JJ
en-wikipedia-org-4107	1818	25	levels	level	NNS
en-wikipedia-org-4107	1818	26	of	of	IN
en-wikipedia-org-4107	1818	27	serum	serum	NN
en-wikipedia-org-4107	1818	28	DβH	DβH	NNP
en-wikipedia-org-4107	1818	29	activity	activity	NN
en-wikipedia-org-4107	1818	30	.	.	.
en-wikipedia-org-4107	1819	1	The	the	DT
en-wikipedia-org-4107	1819	2	percent	percent	NN
en-wikipedia-org-4107	1819	3	of	of	IN
en-wikipedia-org-4107	1819	4	the	the	DT
en-wikipedia-org-4107	1819	5	drug	drug	NN
en-wikipedia-org-4107	1819	6	hydroxylated	hydroxylate	VBN
en-wikipedia-org-4107	1819	7	to	to	TO
en-wikipedia-org-4107	1819	8	hydroxynorephedrine	hydroxynorephedrine	VB
en-wikipedia-org-4107	1819	9	was	be	VBD
en-wikipedia-org-4107	1819	10	comparable	comparable	JJ
en-wikipedia-org-4107	1819	11	in	in	IN
en-wikipedia-org-4107	1819	12	all	all	DT
en-wikipedia-org-4107	1819	13	subjects	subject	NNS
en-wikipedia-org-4107	1819	14	(	(	-LRB-
en-wikipedia-org-4107	1819	15	6.5	6.5	CD
en-wikipedia-org-4107	1819	16	-	-	SYM
en-wikipedia-org-4107	1819	17	9.62	9.62	CD
en-wikipedia-org-4107	1819	18	)	)	-RRB-
en-wikipedia-org-4107	1819	19	(	(	-LRB-
en-wikipedia-org-4107	1819	20	Table	table	NN
en-wikipedia-org-4107	1819	21	3	3	CD
en-wikipedia-org-4107	1819	22	)	)	-RRB-
en-wikipedia-org-4107	1819	23	.	.	.
en-wikipedia-org-4107	1820	1	^	^	NNP
en-wikipedia-org-4107	1820	2	Freeman	Freeman	NNP
en-wikipedia-org-4107	1820	3	JJ	JJ	NNP
en-wikipedia-org-4107	1820	4	,	,	,
en-wikipedia-org-4107	1820	5	Sulser	Sulser	NNP
en-wikipedia-org-4107	1820	6	F	F	NNP
en-wikipedia-org-4107	1820	7	(	(	-LRB-
en-wikipedia-org-4107	1820	8	December	December	NNP
en-wikipedia-org-4107	1820	9	1974	1974	CD
en-wikipedia-org-4107	1820	10	)	)	-RRB-
en-wikipedia-org-4107	1820	11	.	.	.
en-wikipedia-org-4107	1821	1	"	"	``
en-wikipedia-org-4107	1821	2	Formation	formation	NN
en-wikipedia-org-4107	1821	3	of	of	IN
en-wikipedia-org-4107	1821	4	p	p	NN
en-wikipedia-org-4107	1821	5	-	-	HYPH
en-wikipedia-org-4107	1821	6	hydroxynorephedrine	hydroxynorephedrine	NN
en-wikipedia-org-4107	1821	7	in	in	IN
en-wikipedia-org-4107	1821	8	brain	brain	NN
en-wikipedia-org-4107	1821	9	following	follow	VBG
en-wikipedia-org-4107	1821	10	intraventricular	intraventricular	NNP
en-wikipedia-org-4107	1821	11	administration	administration	NN
en-wikipedia-org-4107	1821	12	of	of	IN
en-wikipedia-org-4107	1821	13	p	p	NNP
en-wikipedia-org-4107	1821	14	-	-	HYPH
en-wikipedia-org-4107	1821	15	hydroxyamphetamine	hydroxyamphetamine	NN
en-wikipedia-org-4107	1821	16	"	"	''
en-wikipedia-org-4107	1821	17	.	.	.
en-wikipedia-org-4107	1822	1	Neuropharmacology	neuropharmacology	NN
en-wikipedia-org-4107	1822	2	.	.	.
en-wikipedia-org-4107	1823	1	13	13	CD
en-wikipedia-org-4107	1823	2	(	(	-LRB-
en-wikipedia-org-4107	1823	3	12	12	CD
en-wikipedia-org-4107	1823	4	)	)	-RRB-
en-wikipedia-org-4107	1823	5	:	:	:
en-wikipedia-org-4107	1823	6	1187–1190	1187–1190	CD
en-wikipedia-org-4107	1823	7	.	.	.
en-wikipedia-org-4107	1824	1	doi:10.1016/0028	doi:10.1016/0028	NNP
en-wikipedia-org-4107	1824	2	-	-	:
en-wikipedia-org-4107	1824	3	3908(74)90069	3908(74)90069	NNP
en-wikipedia-org-4107	1824	4	-	-	HYPH
en-wikipedia-org-4107	1824	5	0	0	CD
en-wikipedia-org-4107	1824	6	.	.	.
en-wikipedia-org-4107	1825	1	PMID	PMID	NNP
en-wikipedia-org-4107	1825	2	 	  	_SP
en-wikipedia-org-4107	1825	3	4457764	4457764	CD
en-wikipedia-org-4107	1825	4	.	.	.
en-wikipedia-org-4107	1826	1	In	in	IN
en-wikipedia-org-4107	1826	2	species	specie	NNS
en-wikipedia-org-4107	1826	3	where	where	WRB
en-wikipedia-org-4107	1826	4	aromatic	aromatic	JJ
en-wikipedia-org-4107	1826	5	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	1826	6	of	of	IN
en-wikipedia-org-4107	1826	7	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1826	8	is	be	VBZ
en-wikipedia-org-4107	1826	9	the	the	DT
en-wikipedia-org-4107	1826	10	major	major	JJ
en-wikipedia-org-4107	1826	11	metabolic	metabolic	JJ
en-wikipedia-org-4107	1826	12	pathway	pathway	NN
en-wikipedia-org-4107	1826	13	,	,	,
en-wikipedia-org-4107	1826	14	p	p	NNP
en-wikipedia-org-4107	1826	15	-	-	HYPH
en-wikipedia-org-4107	1826	16	hydroxyamphetamine	hydroxyamphetamine	NN
en-wikipedia-org-4107	1826	17	(	(	-LRB-
en-wikipedia-org-4107	1826	18	POH	POH	NNP
en-wikipedia-org-4107	1826	19	)	)	-RRB-
en-wikipedia-org-4107	1826	20	and	and	CC
en-wikipedia-org-4107	1826	21	p	p	NN
en-wikipedia-org-4107	1826	22	-	-	HYPH
en-wikipedia-org-4107	1826	23	hydroxynorephedrine	hydroxynorephedrine	NN
en-wikipedia-org-4107	1826	24	(	(	-LRB-
en-wikipedia-org-4107	1826	25	PHN	PHN	NNP
en-wikipedia-org-4107	1826	26	)	)	-RRB-
en-wikipedia-org-4107	1826	27	may	may	MD
en-wikipedia-org-4107	1826	28	contribute	contribute	VB
en-wikipedia-org-4107	1826	29	to	to	IN
en-wikipedia-org-4107	1826	30	the	the	DT
en-wikipedia-org-4107	1826	31	pharmacological	pharmacological	JJ
en-wikipedia-org-4107	1826	32	profile	profile	NN
en-wikipedia-org-4107	1826	33	of	of	IN
en-wikipedia-org-4107	1826	34	the	the	DT
en-wikipedia-org-4107	1826	35	parent	parent	NN
en-wikipedia-org-4107	1826	36	drug	drug	NN
en-wikipedia-org-4107	1826	37	.	.	.
en-wikipedia-org-4107	1827	1	...	...	NFP
en-wikipedia-org-4107	1828	1	The	the	DT
en-wikipedia-org-4107	1828	2	location	location	NN
en-wikipedia-org-4107	1828	3	of	of	IN
en-wikipedia-org-4107	1828	4	the	the	DT
en-wikipedia-org-4107	1828	5	p	p	NN
en-wikipedia-org-4107	1828	6	-	-	HYPH
en-wikipedia-org-4107	1828	7	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	1828	8	and	and	CC
en-wikipedia-org-4107	1828	9	β	β	NN
en-wikipedia-org-4107	1828	10	-	-	HYPH
en-wikipedia-org-4107	1828	11	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	1828	12	reactions	reaction	NNS
en-wikipedia-org-4107	1828	13	is	be	VBZ
en-wikipedia-org-4107	1828	14	important	important	JJ
en-wikipedia-org-4107	1828	15	in	in	IN
en-wikipedia-org-4107	1828	16	species	specie	NNS
en-wikipedia-org-4107	1828	17	where	where	WRB
en-wikipedia-org-4107	1828	18	aromatic	aromatic	JJ
en-wikipedia-org-4107	1828	19	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	1828	20	of	of	IN
en-wikipedia-org-4107	1828	21	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1828	22	is	be	VBZ
en-wikipedia-org-4107	1828	23	the	the	DT
en-wikipedia-org-4107	1828	24	predominant	predominant	JJ
en-wikipedia-org-4107	1828	25	pathway	pathway	NN
en-wikipedia-org-4107	1828	26	of	of	IN
en-wikipedia-org-4107	1828	27	metabolism	metabolism	NN
en-wikipedia-org-4107	1828	28	.	.	.
en-wikipedia-org-4107	1829	1	Following	follow	VBG
en-wikipedia-org-4107	1829	2	systemic	systemic	JJ
en-wikipedia-org-4107	1829	3	administration	administration	NN
en-wikipedia-org-4107	1829	4	of	of	IN
en-wikipedia-org-4107	1829	5	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1829	6	to	to	IN
en-wikipedia-org-4107	1829	7	rats	rat	NNS
en-wikipedia-org-4107	1829	8	,	,	,
en-wikipedia-org-4107	1829	9	POH	POH	NNP
en-wikipedia-org-4107	1829	10	has	have	VBZ
en-wikipedia-org-4107	1829	11	been	be	VBN
en-wikipedia-org-4107	1829	12	found	find	VBN
en-wikipedia-org-4107	1829	13	in	in	IN
en-wikipedia-org-4107	1829	14	urine	urine	NN
en-wikipedia-org-4107	1829	15	and	and	CC
en-wikipedia-org-4107	1829	16	in	in	IN
en-wikipedia-org-4107	1829	17	plasma	plasma	NN
en-wikipedia-org-4107	1829	18	.	.	.
en-wikipedia-org-4107	1830	1	The	the	DT
en-wikipedia-org-4107	1830	2	observed	observed	JJ
en-wikipedia-org-4107	1830	3	lack	lack	NN
en-wikipedia-org-4107	1830	4	of	of	IN
en-wikipedia-org-4107	1830	5	a	a	DT
en-wikipedia-org-4107	1830	6	significant	significant	JJ
en-wikipedia-org-4107	1830	7	accumulation	accumulation	NN
en-wikipedia-org-4107	1830	8	of	of	IN
en-wikipedia-org-4107	1830	9	PHN	PHN	NNP
en-wikipedia-org-4107	1830	10	in	in	IN
en-wikipedia-org-4107	1830	11	brain	brain	NN
en-wikipedia-org-4107	1830	12	following	follow	VBG
en-wikipedia-org-4107	1830	13	the	the	DT
en-wikipedia-org-4107	1830	14	intraventricular	intraventricular	NNP
en-wikipedia-org-4107	1830	15	administration	administration	NN
en-wikipedia-org-4107	1830	16	of	of	IN
en-wikipedia-org-4107	1830	17	(	(	-LRB-
en-wikipedia-org-4107	1830	18	+	+	SYM
en-wikipedia-org-4107	1830	19	)	)	-RRB-
en-wikipedia-org-4107	1830	20	-amphetamine	-amphetamine	.
en-wikipedia-org-4107	1830	21	and	and	CC
en-wikipedia-org-4107	1830	22	the	the	DT
en-wikipedia-org-4107	1830	23	formation	formation	NN
en-wikipedia-org-4107	1830	24	of	of	IN
en-wikipedia-org-4107	1830	25	appreciable	appreciable	JJ
en-wikipedia-org-4107	1830	26	amounts	amount	NNS
en-wikipedia-org-4107	1830	27	of	of	IN
en-wikipedia-org-4107	1830	28	PHN	PHN	NNP
en-wikipedia-org-4107	1830	29	from	from	IN
en-wikipedia-org-4107	1830	30	(	(	-LRB-
en-wikipedia-org-4107	1830	31	+	+	SYM
en-wikipedia-org-4107	1830	32	)	)	-RRB-
en-wikipedia-org-4107	1830	33	-POH	-POH	-LRB-
en-wikipedia-org-4107	1830	34	in	in	IN
en-wikipedia-org-4107	1830	35	brain	brain	NN
en-wikipedia-org-4107	1830	36	tissue	tissue	NN
en-wikipedia-org-4107	1830	37	in	in	IN
en-wikipedia-org-4107	1830	38	vivo	vivo	NNP
en-wikipedia-org-4107	1830	39	supports	support	VBZ
en-wikipedia-org-4107	1830	40	the	the	DT
en-wikipedia-org-4107	1830	41	view	view	NN
en-wikipedia-org-4107	1830	42	that	that	IN
en-wikipedia-org-4107	1830	43	the	the	DT
en-wikipedia-org-4107	1830	44	aromatic	aromatic	JJ
en-wikipedia-org-4107	1830	45	hydroxylation	hydroxylation	NN
en-wikipedia-org-4107	1830	46	of	of	IN
en-wikipedia-org-4107	1830	47	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1830	48	following	follow	VBG
en-wikipedia-org-4107	1830	49	its	-PRON-	PRP$
en-wikipedia-org-4107	1830	50	systemic	systemic	JJ
en-wikipedia-org-4107	1830	51	administration	administration	NN
en-wikipedia-org-4107	1830	52	occurs	occur	VBZ
en-wikipedia-org-4107	1830	53	predominantly	predominantly	RB
en-wikipedia-org-4107	1830	54	in	in	IN
en-wikipedia-org-4107	1830	55	the	the	DT
en-wikipedia-org-4107	1830	56	periphery	periphery	NN
en-wikipedia-org-4107	1830	57	,	,	,
en-wikipedia-org-4107	1830	58	and	and	CC
en-wikipedia-org-4107	1830	59	that	that	IN
en-wikipedia-org-4107	1830	60	POH	POH	NNP
en-wikipedia-org-4107	1830	61	is	be	VBZ
en-wikipedia-org-4107	1830	62	then	then	RB
en-wikipedia-org-4107	1830	63	transported	transport	VBN
en-wikipedia-org-4107	1830	64	through	through	IN
en-wikipedia-org-4107	1830	65	the	the	DT
en-wikipedia-org-4107	1830	66	blood	blood	NN
en-wikipedia-org-4107	1830	67	-	-	HYPH
en-wikipedia-org-4107	1830	68	brain	brain	NN
en-wikipedia-org-4107	1830	69	barrier	barrier	NN
en-wikipedia-org-4107	1830	70	,	,	,
en-wikipedia-org-4107	1830	71	taken	take	VBN
en-wikipedia-org-4107	1830	72	up	up	RP
en-wikipedia-org-4107	1830	73	by	by	IN
en-wikipedia-org-4107	1830	74	noradrenergic	noradrenergic	JJ
en-wikipedia-org-4107	1830	75	neurones	neurone	NNS
en-wikipedia-org-4107	1830	76	in	in	IN
en-wikipedia-org-4107	1830	77	brain	brain	NN
en-wikipedia-org-4107	1830	78	where	where	WRB
en-wikipedia-org-4107	1830	79	(	(	-LRB-
en-wikipedia-org-4107	1830	80	+	+	NFP
en-wikipedia-org-4107	1830	81	)	)	-RRB-
en-wikipedia-org-4107	1830	82	-POH	-POH	-LRB-
en-wikipedia-org-4107	1830	83	is	be	VBZ
en-wikipedia-org-4107	1830	84	converted	convert	VBN
en-wikipedia-org-4107	1830	85	in	in	IN
en-wikipedia-org-4107	1830	86	the	the	DT
en-wikipedia-org-4107	1830	87	storage	storage	NN
en-wikipedia-org-4107	1830	88	vesicles	vesicle	NNS
en-wikipedia-org-4107	1830	89	by	by	IN
en-wikipedia-org-4107	1830	90	dopamine	dopamine	NN
en-wikipedia-org-4107	1830	91	β	β	NNP
en-wikipedia-org-4107	1830	92	-	-	HYPH
en-wikipedia-org-4107	1830	93	hydroxylase	hydroxylase	NN
en-wikipedia-org-4107	1830	94	to	to	IN
en-wikipedia-org-4107	1830	95	PHN	PHN	NNP
en-wikipedia-org-4107	1830	96	.	.	.
en-wikipedia-org-4107	1831	1	^	^	NNP
en-wikipedia-org-4107	1831	2	Matsuda	Matsuda	NNP
en-wikipedia-org-4107	1831	3	LA	LA	NNP
en-wikipedia-org-4107	1831	4	,	,	,
en-wikipedia-org-4107	1831	5	Hanson	Hanson	NNP
en-wikipedia-org-4107	1831	6	GR	GR	NNP
en-wikipedia-org-4107	1831	7	,	,	,
en-wikipedia-org-4107	1831	8	Gibb	Gibb	NNP
en-wikipedia-org-4107	1831	9	JW	JW	NNP
en-wikipedia-org-4107	1831	10	(	(	-LRB-
en-wikipedia-org-4107	1831	11	December	December	NNP
en-wikipedia-org-4107	1831	12	1989	1989	CD
en-wikipedia-org-4107	1831	13	)	)	-RRB-
en-wikipedia-org-4107	1831	14	.	.	.
en-wikipedia-org-4107	1832	1	"	"	``
en-wikipedia-org-4107	1832	2	Neurochemical	neurochemical	JJ
en-wikipedia-org-4107	1832	3	effects	effect	NNS
en-wikipedia-org-4107	1832	4	of	of	IN
en-wikipedia-org-4107	1832	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1832	6	metabolites	metabolite	NNS
en-wikipedia-org-4107	1832	7	on	on	IN
en-wikipedia-org-4107	1832	8	central	central	JJ
en-wikipedia-org-4107	1832	9	dopaminergic	dopaminergic	JJ
en-wikipedia-org-4107	1832	10	and	and	CC
en-wikipedia-org-4107	1832	11	serotonergic	serotonergic	JJ
en-wikipedia-org-4107	1832	12	systems	system	NNS
en-wikipedia-org-4107	1832	13	"	"	''
en-wikipedia-org-4107	1832	14	.	.	.
en-wikipedia-org-4107	1833	1	Journal	Journal	NNP
en-wikipedia-org-4107	1833	2	of	of	IN
en-wikipedia-org-4107	1833	3	Pharmacology	Pharmacology	NNP
en-wikipedia-org-4107	1833	4	and	and	CC
en-wikipedia-org-4107	1833	5	Experimental	Experimental	NNP
en-wikipedia-org-4107	1833	6	Therapeutics	Therapeutics	NNP
en-wikipedia-org-4107	1833	7	.	.	.
en-wikipedia-org-4107	1834	1	251	251	CD
en-wikipedia-org-4107	1834	2	(	(	-LRB-
en-wikipedia-org-4107	1834	3	3	3	CD
en-wikipedia-org-4107	1834	4	)	)	-RRB-
en-wikipedia-org-4107	1834	5	:	:	:
en-wikipedia-org-4107	1834	6	901–908	901–908	CD
en-wikipedia-org-4107	1834	7	.	.	.
en-wikipedia-org-4107	1835	1	PMID	PMID	NNP
en-wikipedia-org-4107	1835	2	 	  	_SP
en-wikipedia-org-4107	1835	3	2600821	2600821	CD
en-wikipedia-org-4107	1835	4	.	.	.
en-wikipedia-org-4107	1836	1	The	the	DT
en-wikipedia-org-4107	1836	2	metabolism	metabolism	NN
en-wikipedia-org-4107	1836	3	of	of	IN
en-wikipedia-org-4107	1836	4	p	p	NN
en-wikipedia-org-4107	1836	5	-	-	HYPH
en-wikipedia-org-4107	1836	6	OHA	OHA	NNP
en-wikipedia-org-4107	1836	7	to	to	IN
en-wikipedia-org-4107	1836	8	p	p	NNP
en-wikipedia-org-4107	1836	9	-	-	:
en-wikipedia-org-4107	1836	10	OHNor	OHNor	NNP
en-wikipedia-org-4107	1836	11	is	be	VBZ
en-wikipedia-org-4107	1836	12	well	well	RB
en-wikipedia-org-4107	1836	13	documented	documented	JJ
en-wikipedia-org-4107	1836	14	and	and	CC
en-wikipedia-org-4107	1836	15	dopamine	dopamine	NN
en-wikipedia-org-4107	1836	16	-	-	HYPH
en-wikipedia-org-4107	1836	17	β	β	NN
en-wikipedia-org-4107	1836	18	hydroxylase	hydroxylase	NN
en-wikipedia-org-4107	1836	19	present	present	JJ
en-wikipedia-org-4107	1836	20	in	in	IN
en-wikipedia-org-4107	1836	21	noradrenergic	noradrenergic	JJ
en-wikipedia-org-4107	1836	22	neurons	neuron	NNS
en-wikipedia-org-4107	1836	23	could	could	MD
en-wikipedia-org-4107	1836	24	easily	easily	RB
en-wikipedia-org-4107	1836	25	convert	convert	VB
en-wikipedia-org-4107	1836	26	p	p	NNP
en-wikipedia-org-4107	1836	27	-	-	HYPH
en-wikipedia-org-4107	1836	28	OHA	OHA	NNP
en-wikipedia-org-4107	1836	29	to	to	IN
en-wikipedia-org-4107	1836	30	p	p	NNP
en-wikipedia-org-4107	1836	31	-	-	:
en-wikipedia-org-4107	1836	32	OHNor	OHNor	NNP
en-wikipedia-org-4107	1836	33	after	after	IN
en-wikipedia-org-4107	1836	34	intraventricular	intraventricular	JJ
en-wikipedia-org-4107	1836	35	administration	administration	NN
en-wikipedia-org-4107	1836	36	.	.	.
en-wikipedia-org-4107	1837	1	^	^	NNP
en-wikipedia-org-4107	1837	2	a	a	DT
en-wikipedia-org-4107	1837	3	b	b	NNP
en-wikipedia-org-4107	1837	4	c	c	NNP
en-wikipedia-org-4107	1837	5	d	d	NNP
en-wikipedia-org-4107	1837	6	e	e	NNP
en-wikipedia-org-4107	1837	7	f	f	NNP
en-wikipedia-org-4107	1837	8	ElRakaiby	ElRakaiby	NNP
en-wikipedia-org-4107	1837	9	M	M	NNP
en-wikipedia-org-4107	1837	10	,	,	,
en-wikipedia-org-4107	1837	11	Dutilh	Dutilh	NNP
en-wikipedia-org-4107	1837	12	BE	BE	NNP
en-wikipedia-org-4107	1837	13	,	,	,
en-wikipedia-org-4107	1837	14	Rizkallah	Rizkallah	NNP
en-wikipedia-org-4107	1837	15	MR	MR	NNP
en-wikipedia-org-4107	1837	16	,	,	,
en-wikipedia-org-4107	1837	17	Boleij	Boleij	NNP
en-wikipedia-org-4107	1837	18	A	A	NNP
en-wikipedia-org-4107	1837	19	,	,	,
en-wikipedia-org-4107	1837	20	Cole	Cole	NNP
en-wikipedia-org-4107	1837	21	JN	JN	NNP
en-wikipedia-org-4107	1837	22	,	,	,
en-wikipedia-org-4107	1837	23	Aziz	Aziz	NNP
en-wikipedia-org-4107	1837	24	RK	RK	NNP
en-wikipedia-org-4107	1837	25	(	(	-LRB-
en-wikipedia-org-4107	1837	26	July	July	NNP
en-wikipedia-org-4107	1837	27	2014	2014	CD
en-wikipedia-org-4107	1837	28	)	)	-RRB-
en-wikipedia-org-4107	1837	29	.	.	.
en-wikipedia-org-4107	1838	1	"	"	``
en-wikipedia-org-4107	1838	2	Pharmacomicrobiomics	pharmacomicrobiomic	NNS
en-wikipedia-org-4107	1838	3	:	:	:
en-wikipedia-org-4107	1838	4	the	the	DT
en-wikipedia-org-4107	1838	5	impact	impact	NN
en-wikipedia-org-4107	1838	6	of	of	IN
en-wikipedia-org-4107	1838	7	human	human	JJ
en-wikipedia-org-4107	1838	8	microbiome	microbiome	NN
en-wikipedia-org-4107	1838	9	variations	variation	NNS
en-wikipedia-org-4107	1838	10	on	on	IN
en-wikipedia-org-4107	1838	11	systems	system	NNS
en-wikipedia-org-4107	1838	12	pharmacology	pharmacology	NN
en-wikipedia-org-4107	1838	13	and	and	CC
en-wikipedia-org-4107	1838	14	personalized	personalized	JJ
en-wikipedia-org-4107	1838	15	therapeutics	therapeutic	NNS
en-wikipedia-org-4107	1838	16	"	"	''
en-wikipedia-org-4107	1838	17	.	.	.
en-wikipedia-org-4107	1839	1	Omics	omic	NNS
en-wikipedia-org-4107	1839	2	.	.	.
en-wikipedia-org-4107	1840	1	18	18	CD
en-wikipedia-org-4107	1840	2	(	(	-LRB-
en-wikipedia-org-4107	1840	3	7	7	CD
en-wikipedia-org-4107	1840	4	)	)	-RRB-
en-wikipedia-org-4107	1840	5	:	:	:
en-wikipedia-org-4107	1840	6	402–414	402–414	CD
en-wikipedia-org-4107	1840	7	.	.	.
en-wikipedia-org-4107	1841	1	doi:10.1089	doi:10.1089	NNP
en-wikipedia-org-4107	1841	2	/	/	SYM
en-wikipedia-org-4107	1841	3	omi.2014.0018	omi.2014.0018	NNP
en-wikipedia-org-4107	1841	4	.	.	.
en-wikipedia-org-4107	1842	1	PMC	PMC	NNP
en-wikipedia-org-4107	1842	2	 	  	_SP
en-wikipedia-org-4107	1842	3	4086029	4086029	CD
en-wikipedia-org-4107	1842	4	.	.	.
en-wikipedia-org-4107	1843	1	PMID	PMID	NNP
en-wikipedia-org-4107	1843	2	 	  	_SP
en-wikipedia-org-4107	1843	3	24785449	24785449	CD
en-wikipedia-org-4107	1843	4	.	.	.
en-wikipedia-org-4107	1844	1	The	the	DT
en-wikipedia-org-4107	1844	2	hundred	hundred	CD
en-wikipedia-org-4107	1844	3	trillion	trillion	CD
en-wikipedia-org-4107	1844	4	microbes	microbe	NNS
en-wikipedia-org-4107	1844	5	and	and	CC
en-wikipedia-org-4107	1844	6	viruses	virus	NNS
en-wikipedia-org-4107	1844	7	residing	reside	VBG
en-wikipedia-org-4107	1844	8	in	in	IN
en-wikipedia-org-4107	1844	9	every	every	DT
en-wikipedia-org-4107	1844	10	human	human	JJ
en-wikipedia-org-4107	1844	11	body	body	NN
en-wikipedia-org-4107	1844	12	,	,	,
en-wikipedia-org-4107	1844	13	which	which	WDT
en-wikipedia-org-4107	1844	14	outnumber	outnumber	VBP
en-wikipedia-org-4107	1844	15	human	human	JJ
en-wikipedia-org-4107	1844	16	cells	cell	NNS
en-wikipedia-org-4107	1844	17	and	and	CC
en-wikipedia-org-4107	1844	18	contribute	contribute	VB
en-wikipedia-org-4107	1844	19	at	at	IN
en-wikipedia-org-4107	1844	20	least	least	RBS
en-wikipedia-org-4107	1844	21	100	100	CD
en-wikipedia-org-4107	1844	22	times	time	NNS
en-wikipedia-org-4107	1844	23	more	more	JJR
en-wikipedia-org-4107	1844	24	genes	gene	NNS
en-wikipedia-org-4107	1844	25	than	than	IN
en-wikipedia-org-4107	1844	26	those	those	DT
en-wikipedia-org-4107	1844	27	encoded	encode	VBN
en-wikipedia-org-4107	1844	28	on	on	IN
en-wikipedia-org-4107	1844	29	the	the	DT
en-wikipedia-org-4107	1844	30	human	human	JJ
en-wikipedia-org-4107	1844	31	genome	genome	NN
en-wikipedia-org-4107	1844	32	(	(	-LRB-
en-wikipedia-org-4107	1844	33	Ley	Ley	NNP
en-wikipedia-org-4107	1844	34	et	et	NNP
en-wikipedia-org-4107	1844	35	al	al	NNP
en-wikipedia-org-4107	1844	36	.	.	NNP
en-wikipedia-org-4107	1844	37	,	,	,
en-wikipedia-org-4107	1844	38	2006	2006	CD
en-wikipedia-org-4107	1844	39	)	)	-RRB-
en-wikipedia-org-4107	1844	40	,	,	,
en-wikipedia-org-4107	1844	41	offer	offer	VBP
en-wikipedia-org-4107	1844	42	an	an	DT
en-wikipedia-org-4107	1844	43	immense	immense	JJ
en-wikipedia-org-4107	1844	44	accessory	accessory	JJ
en-wikipedia-org-4107	1844	45	pool	pool	NN
en-wikipedia-org-4107	1844	46	for	for	IN
en-wikipedia-org-4107	1844	47	inter	inter	JJ
en-wikipedia-org-4107	1844	48	-	-	JJ
en-wikipedia-org-4107	1844	49	individual	individual	JJ
en-wikipedia-org-4107	1844	50	genetic	genetic	JJ
en-wikipedia-org-4107	1844	51	variation	variation	NN
en-wikipedia-org-4107	1844	52	that	that	WDT
en-wikipedia-org-4107	1844	53	has	have	VBZ
en-wikipedia-org-4107	1844	54	been	be	VBN
en-wikipedia-org-4107	1844	55	underestimated	underestimate	VBN
en-wikipedia-org-4107	1844	56	and	and	CC
en-wikipedia-org-4107	1844	57	largely	largely	RB
en-wikipedia-org-4107	1844	58	unexplored	unexplored	JJ
en-wikipedia-org-4107	1844	59	(	(	-LRB-
en-wikipedia-org-4107	1844	60	Savage	Savage	NNP
en-wikipedia-org-4107	1844	61	,	,	,
en-wikipedia-org-4107	1844	62	1977	1977	CD
en-wikipedia-org-4107	1844	63	;	;	:
en-wikipedia-org-4107	1844	64	Medini	Medini	NNP
en-wikipedia-org-4107	1844	65	et	et	NNP
en-wikipedia-org-4107	1844	66	al	al	NNP
en-wikipedia-org-4107	1844	67	.	.	NNP
en-wikipedia-org-4107	1844	68	,	,	,
en-wikipedia-org-4107	1844	69	2008	2008	CD
en-wikipedia-org-4107	1844	70	;	;	:
en-wikipedia-org-4107	1844	71	Minot	Minot	NNP
en-wikipedia-org-4107	1844	72	et	et	NNP
en-wikipedia-org-4107	1844	73	al	al	NNP
en-wikipedia-org-4107	1844	74	.	.	NNP
en-wikipedia-org-4107	1844	75	,	,	,
en-wikipedia-org-4107	1844	76	2011	2011	CD
en-wikipedia-org-4107	1844	77	;	;	:
en-wikipedia-org-4107	1844	78	Wylie	Wylie	NNP
en-wikipedia-org-4107	1844	79	et	et	NNP
en-wikipedia-org-4107	1844	80	al	al	NNP
en-wikipedia-org-4107	1844	81	.	.	NNP
en-wikipedia-org-4107	1844	82	,	,	,
en-wikipedia-org-4107	1844	83	2012	2012	CD
en-wikipedia-org-4107	1844	84	)	)	-RRB-
en-wikipedia-org-4107	1844	85	.	.	.
en-wikipedia-org-4107	1845	1	...	...	NFP
en-wikipedia-org-4107	1846	1	Meanwhile	meanwhile	RB
en-wikipedia-org-4107	1846	2	,	,	,
en-wikipedia-org-4107	1846	3	a	a	DT
en-wikipedia-org-4107	1846	4	wealth	wealth	NN
en-wikipedia-org-4107	1846	5	of	of	IN
en-wikipedia-org-4107	1846	6	literature	literature	NN
en-wikipedia-org-4107	1846	7	has	have	VBZ
en-wikipedia-org-4107	1846	8	long	long	RB
en-wikipedia-org-4107	1846	9	been	be	VBN
en-wikipedia-org-4107	1846	10	available	available	JJ
en-wikipedia-org-4107	1846	11	about	about	IN
en-wikipedia-org-4107	1846	12	the	the	DT
en-wikipedia-org-4107	1846	13	biotransformation	biotransformation	NN
en-wikipedia-org-4107	1846	14	of	of	IN
en-wikipedia-org-4107	1846	15	xenobiotics	xenobiotic	NNS
en-wikipedia-org-4107	1846	16	,	,	,
en-wikipedia-org-4107	1846	17	notably	notably	RB
en-wikipedia-org-4107	1846	18	by	by	IN
en-wikipedia-org-4107	1846	19	gut	gut	NNP
en-wikipedia-org-4107	1846	20	bacteria	bacteria	NNS
en-wikipedia-org-4107	1846	21	(	(	-LRB-
en-wikipedia-org-4107	1846	22	reviewed	review	VBN
en-wikipedia-org-4107	1846	23	in	in	IN
en-wikipedia-org-4107	1846	24	Sousa	Sousa	NNP
en-wikipedia-org-4107	1846	25	et	et	NNP
en-wikipedia-org-4107	1846	26	al	al	NNP
en-wikipedia-org-4107	1846	27	.	.	NNP
en-wikipedia-org-4107	1846	28	,	,	,
en-wikipedia-org-4107	1846	29	2008	2008	CD
en-wikipedia-org-4107	1846	30	;	;	:
en-wikipedia-org-4107	1846	31	Rizkallah	Rizkallah	NNP
en-wikipedia-org-4107	1846	32	et	et	FW
en-wikipedia-org-4107	1846	33	al	al	NNP
en-wikipedia-org-4107	1846	34	.	.	NNP
en-wikipedia-org-4107	1846	35	,	,	,
en-wikipedia-org-4107	1846	36	2010	2010	CD
en-wikipedia-org-4107	1846	37	;	;	:
en-wikipedia-org-4107	1846	38	Johnson	Johnson	NNP
en-wikipedia-org-4107	1846	39	et	et	NNP
en-wikipedia-org-4107	1846	40	al	al	NNP
en-wikipedia-org-4107	1846	41	.	.	NNP
en-wikipedia-org-4107	1846	42	,	,	,
en-wikipedia-org-4107	1846	43	2012	2012	CD
en-wikipedia-org-4107	1846	44	;	;	:
en-wikipedia-org-4107	1846	45	Haiser	Haiser	NNP
en-wikipedia-org-4107	1846	46	and	and	CC
en-wikipedia-org-4107	1846	47	Turnbaugh	Turnbaugh	NNP
en-wikipedia-org-4107	1846	48	,	,	,
en-wikipedia-org-4107	1846	49	2013	2013	CD
en-wikipedia-org-4107	1846	50	)	)	-RRB-
en-wikipedia-org-4107	1846	51	.	.	.
en-wikipedia-org-4107	1847	1	This	this	DT
en-wikipedia-org-4107	1847	2	valuable	valuable	JJ
en-wikipedia-org-4107	1847	3	information	information	NN
en-wikipedia-org-4107	1847	4	is	be	VBZ
en-wikipedia-org-4107	1847	5	predominantly	predominantly	RB
en-wikipedia-org-4107	1847	6	about	about	IN
en-wikipedia-org-4107	1847	7	drug	drug	NN
en-wikipedia-org-4107	1847	8	metabolism	metabolism	NN
en-wikipedia-org-4107	1847	9	by	by	IN
en-wikipedia-org-4107	1847	10	unknown	unknown	JJ
en-wikipedia-org-4107	1847	11	human	human	NN
en-wikipedia-org-4107	1847	12	-	-	HYPH
en-wikipedia-org-4107	1847	13	associated	associated	JJ
en-wikipedia-org-4107	1847	14	microbes	microbe	NNS
en-wikipedia-org-4107	1847	15	;	;	:
en-wikipedia-org-4107	1847	16	however	however	RB
en-wikipedia-org-4107	1847	17	,	,	,
en-wikipedia-org-4107	1847	18	only	only	RB
en-wikipedia-org-4107	1847	19	a	a	DT
en-wikipedia-org-4107	1847	20	few	few	JJ
en-wikipedia-org-4107	1847	21	cases	case	NNS
en-wikipedia-org-4107	1847	22	of	of	IN
en-wikipedia-org-4107	1847	23	inter	inter	JJ
en-wikipedia-org-4107	1847	24	-	-	JJ
en-wikipedia-org-4107	1847	25	individual	individual	JJ
en-wikipedia-org-4107	1847	26	microbiome	microbiome	NN
en-wikipedia-org-4107	1847	27	variations	variation	NNS
en-wikipedia-org-4107	1847	28	have	have	VBP
en-wikipedia-org-4107	1847	29	been	be	VBN
en-wikipedia-org-4107	1847	30	documented	document	VBN
en-wikipedia-org-4107	1847	31	[	[	-LRB-
en-wikipedia-org-4107	1847	32	e.g.	e.g.	RB
en-wikipedia-org-4107	1847	33	,	,	,
en-wikipedia-org-4107	1847	34	digoxin	digoxin	NN
en-wikipedia-org-4107	1847	35	(	(	-LRB-
en-wikipedia-org-4107	1847	36	Mathan	Mathan	NNP
en-wikipedia-org-4107	1847	37	et	et	NNP
en-wikipedia-org-4107	1847	38	al	al	NNP
en-wikipedia-org-4107	1847	39	.	.	NNP
en-wikipedia-org-4107	1847	40	,	,	,
en-wikipedia-org-4107	1847	41	1989	1989	CD
en-wikipedia-org-4107	1847	42	)	)	-RRB-
en-wikipedia-org-4107	1847	43	and	and	CC
en-wikipedia-org-4107	1847	44	acetaminophen	acetaminophen	NNP
en-wikipedia-org-4107	1847	45	(	(	-LRB-
en-wikipedia-org-4107	1847	46	Clayton	Clayton	NNP
en-wikipedia-org-4107	1847	47	et	et	NNP
en-wikipedia-org-4107	1847	48	al	al	NNP
en-wikipedia-org-4107	1847	49	.	.	NNP
en-wikipedia-org-4107	1847	50	,	,	,
en-wikipedia-org-4107	1847	51	2009	2009	CD
en-wikipedia-org-4107	1847	52	)	)	-RRB-
en-wikipedia-org-4107	1847	53	]	]	-RRB-
en-wikipedia-org-4107	1847	54	.	.	.
en-wikipedia-org-4107	1848	1	^	^	NNP
en-wikipedia-org-4107	1848	2	a	a	DT
en-wikipedia-org-4107	1848	3	b	b	NN
en-wikipedia-org-4107	1848	4	c	c	NN
en-wikipedia-org-4107	1848	5	Cho	Cho	NNP
en-wikipedia-org-4107	1848	6	I	I	NNP
en-wikipedia-org-4107	1848	7	,	,	,
en-wikipedia-org-4107	1848	8	Blaser	Blaser	NNP
en-wikipedia-org-4107	1848	9	MJ	MJ	NNP
en-wikipedia-org-4107	1848	10	(	(	-LRB-
en-wikipedia-org-4107	1848	11	March	March	NNP
en-wikipedia-org-4107	1848	12	2012	2012	CD
en-wikipedia-org-4107	1848	13	)	)	-RRB-
en-wikipedia-org-4107	1848	14	.	.	.
en-wikipedia-org-4107	1849	1	"	"	``
en-wikipedia-org-4107	1849	2	The	the	DT
en-wikipedia-org-4107	1849	3	human	human	JJ
en-wikipedia-org-4107	1849	4	microbiome	microbiome	NN
en-wikipedia-org-4107	1849	5	:	:	:
en-wikipedia-org-4107	1849	6	at	at	IN
en-wikipedia-org-4107	1849	7	the	the	DT
en-wikipedia-org-4107	1849	8	interface	interface	NN
en-wikipedia-org-4107	1849	9	of	of	IN
en-wikipedia-org-4107	1849	10	health	health	NN
en-wikipedia-org-4107	1849	11	and	and	CC
en-wikipedia-org-4107	1849	12	disease	disease	NNP
en-wikipedia-org-4107	1849	13	"	"	''
en-wikipedia-org-4107	1849	14	.	.	.
en-wikipedia-org-4107	1850	1	Nature	Nature	NNP
en-wikipedia-org-4107	1850	2	Reviews	Reviews	NNPS
en-wikipedia-org-4107	1850	3	Genetics	Genetics	NNP
en-wikipedia-org-4107	1850	4	.	.	.
en-wikipedia-org-4107	1851	1	13	13	CD
en-wikipedia-org-4107	1851	2	(	(	-LRB-
en-wikipedia-org-4107	1851	3	4	4	CD
en-wikipedia-org-4107	1851	4	)	)	-RRB-
en-wikipedia-org-4107	1851	5	:	:	:
en-wikipedia-org-4107	1851	6	260–270	260–270	CD
en-wikipedia-org-4107	1851	7	.	.	.
en-wikipedia-org-4107	1852	1	doi:10.1038	doi:10.1038	NNP
en-wikipedia-org-4107	1852	2	/	/	SYM
en-wikipedia-org-4107	1852	3	nrg3182	nrg3182	NNP
en-wikipedia-org-4107	1852	4	.	.	.
en-wikipedia-org-4107	1853	1	PMC	PMC	NNP
en-wikipedia-org-4107	1853	2	 	  	_SP
en-wikipedia-org-4107	1853	3	3418802	3418802	CD
en-wikipedia-org-4107	1853	4	.	.	.
en-wikipedia-org-4107	1854	1	PMID	PMID	NNP
en-wikipedia-org-4107	1854	2	 	  	_SP
en-wikipedia-org-4107	1854	3	22411464	22411464	CD
en-wikipedia-org-4107	1854	4	.	.	.
en-wikipedia-org-4107	1855	1	The	the	DT
en-wikipedia-org-4107	1855	2	composition	composition	NN
en-wikipedia-org-4107	1855	3	of	of	IN
en-wikipedia-org-4107	1855	4	the	the	DT
en-wikipedia-org-4107	1855	5	microbiome	microbiome	JJ
en-wikipedia-org-4107	1855	6	varies	varie	NNS
en-wikipedia-org-4107	1855	7	by	by	IN
en-wikipedia-org-4107	1855	8	anatomical	anatomical	JJ
en-wikipedia-org-4107	1855	9	site	site	NN
en-wikipedia-org-4107	1855	10	(	(	-LRB-
en-wikipedia-org-4107	1855	11	Figure	figure	NN
en-wikipedia-org-4107	1855	12	1	1	CD
en-wikipedia-org-4107	1855	13	)	)	-RRB-
en-wikipedia-org-4107	1855	14	.	.	.
en-wikipedia-org-4107	1856	1	The	the	DT
en-wikipedia-org-4107	1856	2	primary	primary	JJ
en-wikipedia-org-4107	1856	3	determinant	determinant	NN
en-wikipedia-org-4107	1856	4	of	of	IN
en-wikipedia-org-4107	1856	5	community	community	NN
en-wikipedia-org-4107	1856	6	composition	composition	NN
en-wikipedia-org-4107	1856	7	is	be	VBZ
en-wikipedia-org-4107	1856	8	anatomical	anatomical	JJ
en-wikipedia-org-4107	1856	9	location	location	NN
en-wikipedia-org-4107	1856	10	:	:	:
en-wikipedia-org-4107	1856	11	interpersonal	interpersonal	JJ
en-wikipedia-org-4107	1856	12	variation	variation	NN
en-wikipedia-org-4107	1856	13	is	be	VBZ
en-wikipedia-org-4107	1856	14	substantial23,24	substantial23,24	NNP
en-wikipedia-org-4107	1856	15	and	and	CC
en-wikipedia-org-4107	1856	16	is	be	VBZ
en-wikipedia-org-4107	1856	17	higher	high	JJR
en-wikipedia-org-4107	1856	18	than	than	IN
en-wikipedia-org-4107	1856	19	the	the	DT
en-wikipedia-org-4107	1856	20	temporal	temporal	JJ
en-wikipedia-org-4107	1856	21	variability	variability	NN
en-wikipedia-org-4107	1856	22	seen	see	VBN
en-wikipedia-org-4107	1856	23	at	at	IN
en-wikipedia-org-4107	1856	24	most	most	JJS
en-wikipedia-org-4107	1856	25	sites	site	NNS
en-wikipedia-org-4107	1856	26	in	in	IN
en-wikipedia-org-4107	1856	27	a	a	DT
en-wikipedia-org-4107	1856	28	single	single	JJ
en-wikipedia-org-4107	1856	29	individual25	individual25	NN
en-wikipedia-org-4107	1856	30	.	.	.
en-wikipedia-org-4107	1857	1	...	...	NFP
en-wikipedia-org-4107	1857	2	How	how	WRB
en-wikipedia-org-4107	1857	3	does	do	VBZ
en-wikipedia-org-4107	1857	4	the	the	DT
en-wikipedia-org-4107	1857	5	microbiome	microbiome	NN
en-wikipedia-org-4107	1857	6	affect	affect	VB
en-wikipedia-org-4107	1857	7	the	the	DT
en-wikipedia-org-4107	1857	8	pharmacology	pharmacology	NN
en-wikipedia-org-4107	1857	9	of	of	IN
en-wikipedia-org-4107	1857	10	medications	medication	NNS
en-wikipedia-org-4107	1857	11	?	?	.
en-wikipedia-org-4107	1858	1	Can	Can	MD
en-wikipedia-org-4107	1858	2	we	-PRON-	PRP
en-wikipedia-org-4107	1858	3	"	"	``
en-wikipedia-org-4107	1858	4	micro	micro	JJ
en-wikipedia-org-4107	1858	5	-	-	HYPH
en-wikipedia-org-4107	1858	6	type	type	NN
en-wikipedia-org-4107	1858	7	"	"	``
en-wikipedia-org-4107	1858	8	people	people	NNS
en-wikipedia-org-4107	1858	9	to	to	TO
en-wikipedia-org-4107	1858	10	improve	improve	VB
en-wikipedia-org-4107	1858	11	pharmacokinetics	pharmacokinetic	NNS
en-wikipedia-org-4107	1858	12	and/or	and/or	CC
en-wikipedia-org-4107	1858	13	reduce	reduce	VB
en-wikipedia-org-4107	1858	14	toxicity	toxicity	NN
en-wikipedia-org-4107	1858	15	?	?	.
en-wikipedia-org-4107	1859	1	Can	Can	MD
en-wikipedia-org-4107	1859	2	we	-PRON-	PRP
en-wikipedia-org-4107	1859	3	manipulate	manipulate	VB
en-wikipedia-org-4107	1859	4	the	the	DT
en-wikipedia-org-4107	1859	5	microbiome	microbiome	NN
en-wikipedia-org-4107	1859	6	to	to	TO
en-wikipedia-org-4107	1859	7	improve	improve	VB
en-wikipedia-org-4107	1859	8	pharmacokinetic	pharmacokinetic	JJ
en-wikipedia-org-4107	1859	9	stability	stability	NN
en-wikipedia-org-4107	1859	10	?	?	.
en-wikipedia-org-4107	1860	1	^	^	NNP
en-wikipedia-org-4107	1860	2	Hutter	Hutter	NNP
en-wikipedia-org-4107	1860	3	T	T	NNP
en-wikipedia-org-4107	1860	4	,	,	,
en-wikipedia-org-4107	1860	5	Gimbert	Gimbert	NNP
en-wikipedia-org-4107	1860	6	C	C	NNP
en-wikipedia-org-4107	1860	7	,	,	,
en-wikipedia-org-4107	1860	8	Bouchard	Bouchard	NNP
en-wikipedia-org-4107	1860	9	F	F	NNP
en-wikipedia-org-4107	1860	10	,	,	,
en-wikipedia-org-4107	1860	11	Lapointe	Lapointe	NNP
en-wikipedia-org-4107	1860	12	FJ	FJ	NNP
en-wikipedia-org-4107	1860	13	(	(	-LRB-
en-wikipedia-org-4107	1860	14	2015	2015	CD
en-wikipedia-org-4107	1860	15	)	)	-RRB-
en-wikipedia-org-4107	1860	16	.	.	.
en-wikipedia-org-4107	1861	1	"	"	``
en-wikipedia-org-4107	1861	2	Being	be	VBG
en-wikipedia-org-4107	1861	3	human	human	JJ
en-wikipedia-org-4107	1861	4	is	be	VBZ
en-wikipedia-org-4107	1861	5	a	a	DT
en-wikipedia-org-4107	1861	6	gut	gut	NN
en-wikipedia-org-4107	1861	7	feeling	feeling	NN
en-wikipedia-org-4107	1861	8	"	"	''
en-wikipedia-org-4107	1861	9	.	.	.
en-wikipedia-org-4107	1862	1	Microbiome	Microbiome	NNP
en-wikipedia-org-4107	1862	2	.	.	.
en-wikipedia-org-4107	1863	1	3	3	CD
en-wikipedia-org-4107	1863	2	:	:	SYM
en-wikipedia-org-4107	1863	3	9	9	CD
en-wikipedia-org-4107	1863	4	.	.	.
en-wikipedia-org-4107	1863	5	doi:10.1186	doi:10.1186	NNP
en-wikipedia-org-4107	1863	6	/	/	SYM
en-wikipedia-org-4107	1863	7	s40168	s40168	NN
en-wikipedia-org-4107	1863	8	-	-	HYPH
en-wikipedia-org-4107	1863	9	015	015	CD
en-wikipedia-org-4107	1863	10	-	-	HYPH
en-wikipedia-org-4107	1863	11	0076	0076	CD
en-wikipedia-org-4107	1863	12	-	-	HYPH
en-wikipedia-org-4107	1863	13	7	7	CD
en-wikipedia-org-4107	1863	14	.	.	.
en-wikipedia-org-4107	1864	1	PMC	PMC	NNP
en-wikipedia-org-4107	1864	2	 	  	_SP
en-wikipedia-org-4107	1864	3	4359430	4359430	CD
en-wikipedia-org-4107	1864	4	.	.	.
en-wikipedia-org-4107	1865	1	PMID	PMID	NNP
en-wikipedia-org-4107	1865	2	 	  	_SP
en-wikipedia-org-4107	1865	3	25774294	25774294	CD
en-wikipedia-org-4107	1865	4	.	.	.
en-wikipedia-org-4107	1866	1	Some	some	DT
en-wikipedia-org-4107	1866	2	metagenomic	metagenomic	JJ
en-wikipedia-org-4107	1866	3	studies	study	NNS
en-wikipedia-org-4107	1866	4	have	have	VBP
en-wikipedia-org-4107	1866	5	suggested	suggest	VBN
en-wikipedia-org-4107	1866	6	that	that	IN
en-wikipedia-org-4107	1866	7	less	less	JJR
en-wikipedia-org-4107	1866	8	than	than	IN
en-wikipedia-org-4107	1866	9	10	10	CD
en-wikipedia-org-4107	1866	10	%	%	NN
en-wikipedia-org-4107	1866	11	of	of	IN
en-wikipedia-org-4107	1866	12	the	the	DT
en-wikipedia-org-4107	1866	13	cells	cell	NNS
en-wikipedia-org-4107	1866	14	that	that	WDT
en-wikipedia-org-4107	1866	15	comprise	comprise	VBP
en-wikipedia-org-4107	1866	16	our	-PRON-	PRP$
en-wikipedia-org-4107	1866	17	bodies	body	NNS
en-wikipedia-org-4107	1866	18	are	be	VBP
en-wikipedia-org-4107	1866	19	Homo	Homo	NNP
en-wikipedia-org-4107	1866	20	sapiens	sapiens	JJ
en-wikipedia-org-4107	1866	21	cells	cell	NNS
en-wikipedia-org-4107	1866	22	.	.	.
en-wikipedia-org-4107	1867	1	The	the	DT
en-wikipedia-org-4107	1867	2	remaining	remain	VBG
en-wikipedia-org-4107	1867	3	90	90	CD
en-wikipedia-org-4107	1867	4	%	%	NN
en-wikipedia-org-4107	1867	5	are	be	VBP
en-wikipedia-org-4107	1867	6	bacterial	bacterial	JJ
en-wikipedia-org-4107	1867	7	cells	cell	NNS
en-wikipedia-org-4107	1867	8	.	.	.
en-wikipedia-org-4107	1868	1	The	the	DT
en-wikipedia-org-4107	1868	2	description	description	NN
en-wikipedia-org-4107	1868	3	of	of	IN
en-wikipedia-org-4107	1868	4	this	this	DT
en-wikipedia-org-4107	1868	5	so	so	RB
en-wikipedia-org-4107	1868	6	-	-	HYPH
en-wikipedia-org-4107	1868	7	called	call	VBN
en-wikipedia-org-4107	1868	8	human	human	JJ
en-wikipedia-org-4107	1868	9	microbiome	microbiome	NN
en-wikipedia-org-4107	1868	10	is	be	VBZ
en-wikipedia-org-4107	1868	11	of	of	IN
en-wikipedia-org-4107	1868	12	great	great	JJ
en-wikipedia-org-4107	1868	13	interest	interest	NN
en-wikipedia-org-4107	1868	14	and	and	CC
en-wikipedia-org-4107	1868	15	importance	importance	NN
en-wikipedia-org-4107	1868	16	for	for	IN
en-wikipedia-org-4107	1868	17	several	several	JJ
en-wikipedia-org-4107	1868	18	reasons	reason	NNS
en-wikipedia-org-4107	1868	19	.	.	.
en-wikipedia-org-4107	1869	1	For	for	IN
en-wikipedia-org-4107	1869	2	one	one	CD
en-wikipedia-org-4107	1869	3	,	,	,
en-wikipedia-org-4107	1869	4	it	-PRON-	PRP
en-wikipedia-org-4107	1869	5	helps	help	VBZ
en-wikipedia-org-4107	1869	6	us	-PRON-	PRP
en-wikipedia-org-4107	1869	7	redefine	redefine	VB
en-wikipedia-org-4107	1869	8	what	what	WP
en-wikipedia-org-4107	1869	9	a	a	DT
en-wikipedia-org-4107	1869	10	biological	biological	JJ
en-wikipedia-org-4107	1869	11	individual	individual	NN
en-wikipedia-org-4107	1869	12	is	be	VBZ
en-wikipedia-org-4107	1869	13	.	.	.
en-wikipedia-org-4107	1870	1	We	-PRON-	PRP
en-wikipedia-org-4107	1870	2	suggest	suggest	VBP
en-wikipedia-org-4107	1870	3	that	that	IN
en-wikipedia-org-4107	1870	4	a	a	DT
en-wikipedia-org-4107	1870	5	human	human	JJ
en-wikipedia-org-4107	1870	6	individual	individual	NN
en-wikipedia-org-4107	1870	7	is	be	VBZ
en-wikipedia-org-4107	1870	8	now	now	RB
en-wikipedia-org-4107	1870	9	best	best	RB
en-wikipedia-org-4107	1870	10	described	describe	VBN
en-wikipedia-org-4107	1870	11	as	as	IN
en-wikipedia-org-4107	1870	12	a	a	DT
en-wikipedia-org-4107	1870	13	super	super	JJ
en-wikipedia-org-4107	1870	14	-	-	JJ
en-wikipedia-org-4107	1870	15	individual	individual	JJ
en-wikipedia-org-4107	1870	16	in	in	IN
en-wikipedia-org-4107	1870	17	which	which	WDT
en-wikipedia-org-4107	1870	18	a	a	DT
en-wikipedia-org-4107	1870	19	large	large	JJ
en-wikipedia-org-4107	1870	20	number	number	NN
en-wikipedia-org-4107	1870	21	of	of	IN
en-wikipedia-org-4107	1870	22	different	different	JJ
en-wikipedia-org-4107	1870	23	species	specie	NNS
en-wikipedia-org-4107	1870	24	(	(	-LRB-
en-wikipedia-org-4107	1870	25	including	include	VBG
en-wikipedia-org-4107	1870	26	Homo	Homo	NNP
en-wikipedia-org-4107	1870	27	sapiens	sapiens	JJ
en-wikipedia-org-4107	1870	28	)	)	-RRB-
en-wikipedia-org-4107	1870	29	coexist	coexist	NN
en-wikipedia-org-4107	1870	30	.	.	.
en-wikipedia-org-4107	1871	1	^	^	NNP
en-wikipedia-org-4107	1871	2	a	a	DT
en-wikipedia-org-4107	1871	3	b	b	NN
en-wikipedia-org-4107	1871	4	c	c	NN
en-wikipedia-org-4107	1871	5	d	d	NN
en-wikipedia-org-4107	1871	6	Kumar	Kumar	NNP
en-wikipedia-org-4107	1871	7	K	K	NNP
en-wikipedia-org-4107	1871	8	,	,	,
en-wikipedia-org-4107	1871	9	Dhoke	Dhoke	NNP
en-wikipedia-org-4107	1871	10	GV	GV	NNP
en-wikipedia-org-4107	1871	11	,	,	,
en-wikipedia-org-4107	1871	12	Sharma	Sharma	NNP
en-wikipedia-org-4107	1871	13	AK	AK	NNP
en-wikipedia-org-4107	1871	14	,	,	,
en-wikipedia-org-4107	1871	15	Jaiswal	Jaiswal	NNP
en-wikipedia-org-4107	1871	16	SK	SK	NNP
en-wikipedia-org-4107	1871	17	,	,	,
en-wikipedia-org-4107	1871	18	Sharma	Sharma	NNP
en-wikipedia-org-4107	1871	19	VK	VK	NNP
en-wikipedia-org-4107	1871	20	(	(	-LRB-
en-wikipedia-org-4107	1871	21	January	January	NNP
en-wikipedia-org-4107	1871	22	2019	2019	CD
en-wikipedia-org-4107	1871	23	)	)	-RRB-
en-wikipedia-org-4107	1871	24	.	.	.
en-wikipedia-org-4107	1872	1	"	"	``
en-wikipedia-org-4107	1872	2	Mechanistic	mechanistic	JJ
en-wikipedia-org-4107	1872	3	elucidation	elucidation	NN
en-wikipedia-org-4107	1872	4	of	of	IN
en-wikipedia-org-4107	1872	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1872	6	metabolism	metabolism	NN
en-wikipedia-org-4107	1872	7	by	by	IN
en-wikipedia-org-4107	1872	8	tyramine	tyramine	NN
en-wikipedia-org-4107	1872	9	oxidase	oxidase	NN
en-wikipedia-org-4107	1872	10	from	from	IN
en-wikipedia-org-4107	1872	11	human	human	NNP
en-wikipedia-org-4107	1872	12	gut	gut	NNP
en-wikipedia-org-4107	1872	13	microbiota	microbiota	NNP
en-wikipedia-org-4107	1872	14	using	use	VBG
en-wikipedia-org-4107	1872	15	molecular	molecular	JJ
en-wikipedia-org-4107	1872	16	dynamics	dynamic	NNS
en-wikipedia-org-4107	1872	17	simulations	simulation	NNS
en-wikipedia-org-4107	1872	18	"	"	''
en-wikipedia-org-4107	1872	19	.	.	.
en-wikipedia-org-4107	1873	1	Journal	Journal	NNP
en-wikipedia-org-4107	1873	2	of	of	IN
en-wikipedia-org-4107	1873	3	Cellular	Cellular	NNP
en-wikipedia-org-4107	1873	4	Biochemistry	Biochemistry	NNP
en-wikipedia-org-4107	1873	5	.	.	.
en-wikipedia-org-4107	1874	1	120	120	CD
en-wikipedia-org-4107	1874	2	(	(	-LRB-
en-wikipedia-org-4107	1874	3	7	7	CD
en-wikipedia-org-4107	1874	4	)	)	-RRB-
en-wikipedia-org-4107	1874	5	:	:	:
en-wikipedia-org-4107	1874	6	11206–11215	11206–11215	CD
en-wikipedia-org-4107	1874	7	.	.	.
en-wikipedia-org-4107	1875	1	doi:10.1002	doi:10.1002	NNP
en-wikipedia-org-4107	1875	2	/	/	SYM
en-wikipedia-org-4107	1875	3	jcb.28396	jcb.28396	NNP
en-wikipedia-org-4107	1875	4	.	.	.
en-wikipedia-org-4107	1876	1	PMID	PMID	NNP
en-wikipedia-org-4107	1876	2	 	  	_SP
en-wikipedia-org-4107	1876	3	30701587	30701587	CD
en-wikipedia-org-4107	1876	4	.	.	.
en-wikipedia-org-4107	1877	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1877	2	 	  	_SP
en-wikipedia-org-4107	1877	3	73413138	73413138	CD
en-wikipedia-org-4107	1877	4	.	.	.
en-wikipedia-org-4107	1878	1	Particularly	particularly	RB
en-wikipedia-org-4107	1878	2	in	in	IN
en-wikipedia-org-4107	1878	3	the	the	DT
en-wikipedia-org-4107	1878	4	case	case	NN
en-wikipedia-org-4107	1878	5	of	of	IN
en-wikipedia-org-4107	1878	6	the	the	DT
en-wikipedia-org-4107	1878	7	human	human	JJ
en-wikipedia-org-4107	1878	8	gut	gut	NN
en-wikipedia-org-4107	1878	9	,	,	,
en-wikipedia-org-4107	1878	10	which	which	WDT
en-wikipedia-org-4107	1878	11	harbors	harbor	VBZ
en-wikipedia-org-4107	1878	12	a	a	DT
en-wikipedia-org-4107	1878	13	large	large	JJ
en-wikipedia-org-4107	1878	14	diversity	diversity	NN
en-wikipedia-org-4107	1878	15	of	of	IN
en-wikipedia-org-4107	1878	16	bacterial	bacterial	JJ
en-wikipedia-org-4107	1878	17	species	specie	NNS
en-wikipedia-org-4107	1878	18	,	,	,
en-wikipedia-org-4107	1878	19	the	the	DT
en-wikipedia-org-4107	1878	20	differences	difference	NNS
en-wikipedia-org-4107	1878	21	in	in	IN
en-wikipedia-org-4107	1878	22	microbial	microbial	JJ
en-wikipedia-org-4107	1878	23	composition	composition	NN
en-wikipedia-org-4107	1878	24	can	can	MD
en-wikipedia-org-4107	1878	25	significantly	significantly	RB
en-wikipedia-org-4107	1878	26	alter	alter	VB
en-wikipedia-org-4107	1878	27	the	the	DT
en-wikipedia-org-4107	1878	28	metabolic	metabolic	JJ
en-wikipedia-org-4107	1878	29	activity	activity	NN
en-wikipedia-org-4107	1878	30	in	in	IN
en-wikipedia-org-4107	1878	31	the	the	DT
en-wikipedia-org-4107	1878	32	gut	gut	NN
en-wikipedia-org-4107	1878	33	lumen.4	lumen.4	PDT
en-wikipedia-org-4107	1878	34	The	the	DT
en-wikipedia-org-4107	1878	35	differential	differential	JJ
en-wikipedia-org-4107	1878	36	metabolic	metabolic	NN
en-wikipedia-org-4107	1878	37	activity	activity	NN
en-wikipedia-org-4107	1878	38	due	due	IN
en-wikipedia-org-4107	1878	39	to	to	IN
en-wikipedia-org-4107	1878	40	the	the	DT
en-wikipedia-org-4107	1878	41	differences	difference	NNS
en-wikipedia-org-4107	1878	42	in	in	IN
en-wikipedia-org-4107	1878	43	gut	gut	NN
en-wikipedia-org-4107	1878	44	microbial	microbial	JJ
en-wikipedia-org-4107	1878	45	species	specie	NNS
en-wikipedia-org-4107	1878	46	has	have	VBZ
en-wikipedia-org-4107	1878	47	been	be	VBN
en-wikipedia-org-4107	1878	48	recently	recently	RB
en-wikipedia-org-4107	1878	49	linked	link	VBN
en-wikipedia-org-4107	1878	50	with	with	IN
en-wikipedia-org-4107	1878	51	various	various	JJ
en-wikipedia-org-4107	1878	52	metabolic	metabolic	JJ
en-wikipedia-org-4107	1878	53	disorders	disorder	NNS
en-wikipedia-org-4107	1878	54	and	and	CC
en-wikipedia-org-4107	1878	55	diseases.5–12	diseases.5–12	NNP
en-wikipedia-org-4107	1878	56	In	in	IN
en-wikipedia-org-4107	1878	57	addition	addition	NN
en-wikipedia-org-4107	1878	58	to	to	IN
en-wikipedia-org-4107	1878	59	the	the	DT
en-wikipedia-org-4107	1878	60	impact	impact	NN
en-wikipedia-org-4107	1878	61	of	of	IN
en-wikipedia-org-4107	1878	62	gut	gut	NN
en-wikipedia-org-4107	1878	63	microbial	microbial	JJ
en-wikipedia-org-4107	1878	64	diversity	diversity	NN
en-wikipedia-org-4107	1878	65	or	or	CC
en-wikipedia-org-4107	1878	66	dysbiosis	dysbiosis	NN
en-wikipedia-org-4107	1878	67	in	in	IN
en-wikipedia-org-4107	1878	68	various	various	JJ
en-wikipedia-org-4107	1878	69	human	human	JJ
en-wikipedia-org-4107	1878	70	diseases	disease	NNS
en-wikipedia-org-4107	1878	71	,	,	,
en-wikipedia-org-4107	1878	72	there	there	EX
en-wikipedia-org-4107	1878	73	is	be	VBZ
en-wikipedia-org-4107	1878	74	an	an	DT
en-wikipedia-org-4107	1878	75	increasing	increase	VBG
en-wikipedia-org-4107	1878	76	amount	amount	NN
en-wikipedia-org-4107	1878	77	of	of	IN
en-wikipedia-org-4107	1878	78	evidence	evidence	NN
en-wikipedia-org-4107	1878	79	which	which	WDT
en-wikipedia-org-4107	1878	80	shows	show	VBZ
en-wikipedia-org-4107	1878	81	that	that	IN
en-wikipedia-org-4107	1878	82	the	the	DT
en-wikipedia-org-4107	1878	83	gut	gut	NN
en-wikipedia-org-4107	1878	84	microbes	microbe	NNS
en-wikipedia-org-4107	1878	85	can	can	MD
en-wikipedia-org-4107	1878	86	affect	affect	VB
en-wikipedia-org-4107	1878	87	the	the	DT
en-wikipedia-org-4107	1878	88	bioavailability	bioavailability	NN
en-wikipedia-org-4107	1878	89	and	and	CC
en-wikipedia-org-4107	1878	90	efficacy	efficacy	NN
en-wikipedia-org-4107	1878	91	of	of	IN
en-wikipedia-org-4107	1878	92	various	various	JJ
en-wikipedia-org-4107	1878	93	orally	orally	RB
en-wikipedia-org-4107	1878	94	administrated	administrate	VBN
en-wikipedia-org-4107	1878	95	drug	drug	NN
en-wikipedia-org-4107	1878	96	molecules	molecule	NNS
en-wikipedia-org-4107	1878	97	through	through	IN
en-wikipedia-org-4107	1878	98	promiscuous	promiscuous	JJ
en-wikipedia-org-4107	1878	99	enzymatic	enzymatic	JJ
en-wikipedia-org-4107	1878	100	metabolism.13,14	metabolism.13,14	NN
en-wikipedia-org-4107	1878	101	 	  	_SP
en-wikipedia-org-4107	1878	102	...	...	.
en-wikipedia-org-4107	1879	1	The	the	DT
en-wikipedia-org-4107	1879	2	present	present	JJ
en-wikipedia-org-4107	1879	3	study	study	NN
en-wikipedia-org-4107	1879	4	on	on	IN
en-wikipedia-org-4107	1879	5	the	the	DT
en-wikipedia-org-4107	1879	6	atomistic	atomistic	JJ
en-wikipedia-org-4107	1879	7	details	detail	NNS
en-wikipedia-org-4107	1879	8	of	of	IN
en-wikipedia-org-4107	1879	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1879	10	binding	bind	VBG
en-wikipedia-org-4107	1879	11	and	and	CC
en-wikipedia-org-4107	1879	12	binding	bind	VBG
en-wikipedia-org-4107	1879	13	affinity	affinity	NN
en-wikipedia-org-4107	1879	14	to	to	IN
en-wikipedia-org-4107	1879	15	the	the	DT
en-wikipedia-org-4107	1879	16	tyramine	tyramine	JJ
en-wikipedia-org-4107	1879	17	oxidase	oxidase	NN
en-wikipedia-org-4107	1879	18	along	along	IN
en-wikipedia-org-4107	1879	19	with	with	IN
en-wikipedia-org-4107	1879	20	the	the	DT
en-wikipedia-org-4107	1879	21	comparison	comparison	NN
en-wikipedia-org-4107	1879	22	with	with	IN
en-wikipedia-org-4107	1879	23	two	two	CD
en-wikipedia-org-4107	1879	24	natural	natural	JJ
en-wikipedia-org-4107	1879	25	substrates	substrate	NNS
en-wikipedia-org-4107	1879	26	of	of	IN
en-wikipedia-org-4107	1879	27	this	this	DT
en-wikipedia-org-4107	1879	28	enzyme	enzyme	NNS
en-wikipedia-org-4107	1879	29	namely	namely	RB
en-wikipedia-org-4107	1879	30	tyramine	tyramine	NNP
en-wikipedia-org-4107	1879	31	and	and	CC
en-wikipedia-org-4107	1879	32	phenylalanine	phenylalanine	NNP
en-wikipedia-org-4107	1879	33	provides	provide	VBZ
en-wikipedia-org-4107	1879	34	strong	strong	JJ
en-wikipedia-org-4107	1879	35	evidence	evidence	NN
en-wikipedia-org-4107	1879	36	for	for	IN
en-wikipedia-org-4107	1879	37	the	the	DT
en-wikipedia-org-4107	1879	38	promiscuity	promiscuity	NN
en-wikipedia-org-4107	1879	39	-	-	HYPH
en-wikipedia-org-4107	1879	40	based	base	VBN
en-wikipedia-org-4107	1879	41	metabolism	metabolism	NN
en-wikipedia-org-4107	1879	42	of	of	IN
en-wikipedia-org-4107	1879	43	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1879	44	by	by	IN
en-wikipedia-org-4107	1879	45	the	the	DT
en-wikipedia-org-4107	1879	46	tyramine	tyramine	JJ
en-wikipedia-org-4107	1879	47	oxidase	oxidase	JJ
en-wikipedia-org-4107	1879	48	enzyme	enzyme	NNS
en-wikipedia-org-4107	1879	49	of	of	IN
en-wikipedia-org-4107	1879	50	E.	E.	NNP
en-wikipedia-org-4107	1879	51	coli	coli	NNS
en-wikipedia-org-4107	1879	52	.	.	.
en-wikipedia-org-4107	1880	1	The	the	DT
en-wikipedia-org-4107	1880	2	obtained	obtain	VBN
en-wikipedia-org-4107	1880	3	results	result	NNS
en-wikipedia-org-4107	1880	4	will	will	MD
en-wikipedia-org-4107	1880	5	be	be	VB
en-wikipedia-org-4107	1880	6	crucial	crucial	JJ
en-wikipedia-org-4107	1880	7	in	in	IN
en-wikipedia-org-4107	1880	8	designing	design	VBG
en-wikipedia-org-4107	1880	9	a	a	DT
en-wikipedia-org-4107	1880	10	surrogate	surrogate	JJ
en-wikipedia-org-4107	1880	11	molecule	molecule	NN
en-wikipedia-org-4107	1880	12	for	for	IN
en-wikipedia-org-4107	1880	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1880	14	that	that	WDT
en-wikipedia-org-4107	1880	15	can	can	MD
en-wikipedia-org-4107	1880	16	help	help	VB
en-wikipedia-org-4107	1880	17	either	either	CC
en-wikipedia-org-4107	1880	18	in	in	IN
en-wikipedia-org-4107	1880	19	improving	improve	VBG
en-wikipedia-org-4107	1880	20	the	the	DT
en-wikipedia-org-4107	1880	21	efficacy	efficacy	NN
en-wikipedia-org-4107	1880	22	and	and	CC
en-wikipedia-org-4107	1880	23	bioavailability	bioavailability	NN
en-wikipedia-org-4107	1880	24	of	of	IN
en-wikipedia-org-4107	1880	25	the	the	DT
en-wikipedia-org-4107	1880	26	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1880	27	drug	drug	NN
en-wikipedia-org-4107	1880	28	via	via	IN
en-wikipedia-org-4107	1880	29	competitive	competitive	JJ
en-wikipedia-org-4107	1880	30	inhibition	inhibition	NN
en-wikipedia-org-4107	1880	31	or	or	CC
en-wikipedia-org-4107	1880	32	in	in	IN
en-wikipedia-org-4107	1880	33	redesigning	redesign	VBG
en-wikipedia-org-4107	1880	34	the	the	DT
en-wikipedia-org-4107	1880	35	drug	drug	NN
en-wikipedia-org-4107	1880	36	for	for	IN
en-wikipedia-org-4107	1880	37	better	well	JJR
en-wikipedia-org-4107	1880	38	pharmacological	pharmacological	JJ
en-wikipedia-org-4107	1880	39	effects	effect	NNS
en-wikipedia-org-4107	1880	40	.	.	.
en-wikipedia-org-4107	1881	1	This	this	DT
en-wikipedia-org-4107	1881	2	study	study	NN
en-wikipedia-org-4107	1881	3	will	will	MD
en-wikipedia-org-4107	1881	4	also	also	RB
en-wikipedia-org-4107	1881	5	have	have	VB
en-wikipedia-org-4107	1881	6	useful	useful	JJ
en-wikipedia-org-4107	1881	7	clinical	clinical	JJ
en-wikipedia-org-4107	1881	8	implications	implication	NNS
en-wikipedia-org-4107	1881	9	in	in	IN
en-wikipedia-org-4107	1881	10	reducing	reduce	VBG
en-wikipedia-org-4107	1881	11	the	the	DT
en-wikipedia-org-4107	1881	12	gut	gut	NNP
en-wikipedia-org-4107	1881	13	microbiota	microbiota	NNP
en-wikipedia-org-4107	1881	14	caused	cause	VBD
en-wikipedia-org-4107	1881	15	variation	variation	NN
en-wikipedia-org-4107	1881	16	in	in	IN
en-wikipedia-org-4107	1881	17	the	the	DT
en-wikipedia-org-4107	1881	18	drug	drug	NN
en-wikipedia-org-4107	1881	19	response	response	NN
en-wikipedia-org-4107	1881	20	among	among	IN
en-wikipedia-org-4107	1881	21	different	different	JJ
en-wikipedia-org-4107	1881	22	populations	population	NNS
en-wikipedia-org-4107	1881	23	.	.	.
en-wikipedia-org-4107	1882	1	^	^	NNP
en-wikipedia-org-4107	1882	2	a	a	DT
en-wikipedia-org-4107	1882	3	b	b	NN
en-wikipedia-org-4107	1882	4	Khan	Khan	NNP
en-wikipedia-org-4107	1882	5	MZ	MZ	NNP
en-wikipedia-org-4107	1882	6	,	,	,
en-wikipedia-org-4107	1882	7	Nawaz	Nawaz	NNP
en-wikipedia-org-4107	1882	8	W	W	NNP
en-wikipedia-org-4107	1882	9	(	(	-LRB-
en-wikipedia-org-4107	1882	10	October	October	NNP
en-wikipedia-org-4107	1882	11	2016	2016	CD
en-wikipedia-org-4107	1882	12	)	)	-RRB-
en-wikipedia-org-4107	1882	13	.	.	.
en-wikipedia-org-4107	1883	1	"	"	``
en-wikipedia-org-4107	1883	2	The	the	DT
en-wikipedia-org-4107	1883	3	emerging	emerge	VBG
en-wikipedia-org-4107	1883	4	roles	role	NNS
en-wikipedia-org-4107	1883	5	of	of	IN
en-wikipedia-org-4107	1883	6	human	human	JJ
en-wikipedia-org-4107	1883	7	trace	trace	NN
en-wikipedia-org-4107	1883	8	amines	amine	NNS
en-wikipedia-org-4107	1883	9	and	and	CC
en-wikipedia-org-4107	1883	10	human	human	JJ
en-wikipedia-org-4107	1883	11	trace	trace	NN
en-wikipedia-org-4107	1883	12	amine	amine	NN
en-wikipedia-org-4107	1883	13	-	-	HYPH
en-wikipedia-org-4107	1883	14	associated	associate	VBN
en-wikipedia-org-4107	1883	15	receptors	receptor	NNS
en-wikipedia-org-4107	1883	16	(	(	-LRB-
en-wikipedia-org-4107	1883	17	hTAARs	hTAARs	NNP
en-wikipedia-org-4107	1883	18	)	)	-RRB-
en-wikipedia-org-4107	1883	19	in	in	IN
en-wikipedia-org-4107	1883	20	central	central	JJ
en-wikipedia-org-4107	1883	21	nervous	nervous	JJ
en-wikipedia-org-4107	1883	22	system	system	NN
en-wikipedia-org-4107	1883	23	"	"	''
en-wikipedia-org-4107	1883	24	.	.	.
en-wikipedia-org-4107	1884	1	Biomedicine	Biomedicine	NNP
en-wikipedia-org-4107	1884	2	&	&	CC
en-wikipedia-org-4107	1884	3	Pharmacotherapy	Pharmacotherapy	NNP
en-wikipedia-org-4107	1884	4	.	.	.
en-wikipedia-org-4107	1885	1	83	83	CD
en-wikipedia-org-4107	1885	2	:	:	:
en-wikipedia-org-4107	1885	3	439–449	439–449	CD
en-wikipedia-org-4107	1885	4	.	.	.
en-wikipedia-org-4107	1886	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1886	2	/	/	SYM
en-wikipedia-org-4107	1886	3	j.biopha.2016.07.002	j.biopha.2016.07.002	JJ
en-wikipedia-org-4107	1886	4	.	.	.
en-wikipedia-org-4107	1887	1	PMID	PMID	NNP
en-wikipedia-org-4107	1887	2	 	  	_SP
en-wikipedia-org-4107	1887	3	27424325	27424325	CD
en-wikipedia-org-4107	1887	4	.	.	.
en-wikipedia-org-4107	1888	1	^	^	NNP
en-wikipedia-org-4107	1888	2	a	a	DT
en-wikipedia-org-4107	1888	3	b	b	NNP
en-wikipedia-org-4107	1888	4	c	c	NN
en-wikipedia-org-4107	1888	5	d	d	NN
en-wikipedia-org-4107	1888	6	e	e	NN
en-wikipedia-org-4107	1888	7	Lindemann	Lindemann	NNP
en-wikipedia-org-4107	1888	8	L	L	NNP
en-wikipedia-org-4107	1888	9	,	,	,
en-wikipedia-org-4107	1888	10	Hoener	Hoener	NNP
en-wikipedia-org-4107	1888	11	MC	MC	NNP
en-wikipedia-org-4107	1888	12	(	(	-LRB-
en-wikipedia-org-4107	1888	13	May	May	NNP
en-wikipedia-org-4107	1888	14	2005	2005	CD
en-wikipedia-org-4107	1888	15	)	)	-RRB-
en-wikipedia-org-4107	1888	16	.	.	.
en-wikipedia-org-4107	1889	1	"	"	``
en-wikipedia-org-4107	1889	2	A	a	DT
en-wikipedia-org-4107	1889	3	renaissance	renaissance	NN
en-wikipedia-org-4107	1889	4	in	in	IN
en-wikipedia-org-4107	1889	5	trace	trace	NN
en-wikipedia-org-4107	1889	6	amines	amine	NNS
en-wikipedia-org-4107	1889	7	inspired	inspire	VBN
en-wikipedia-org-4107	1889	8	by	by	IN
en-wikipedia-org-4107	1889	9	a	a	DT
en-wikipedia-org-4107	1889	10	novel	novel	JJ
en-wikipedia-org-4107	1889	11	GPCR	GPCR	NNP
en-wikipedia-org-4107	1889	12	family	family	NN
en-wikipedia-org-4107	1889	13	"	"	''
en-wikipedia-org-4107	1889	14	.	.	.
en-wikipedia-org-4107	1890	1	Trends	trend	NNS
en-wikipedia-org-4107	1890	2	in	in	IN
en-wikipedia-org-4107	1890	3	Pharmacological	Pharmacological	NNP
en-wikipedia-org-4107	1890	4	Sciences	Sciences	NNPS
en-wikipedia-org-4107	1890	5	.	.	.
en-wikipedia-org-4107	1891	1	26	26	CD
en-wikipedia-org-4107	1891	2	(	(	-LRB-
en-wikipedia-org-4107	1891	3	5	5	CD
en-wikipedia-org-4107	1891	4	)	)	-RRB-
en-wikipedia-org-4107	1891	5	:	:	:
en-wikipedia-org-4107	1891	6	274–281	274–281	CD
en-wikipedia-org-4107	1891	7	.	.	.
en-wikipedia-org-4107	1892	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1892	2	/	/	SYM
en-wikipedia-org-4107	1892	3	j.tips.2005.03.007	j.tips.2005.03.007	NN
en-wikipedia-org-4107	1892	4	.	.	.
en-wikipedia-org-4107	1893	1	PMID	PMID	NNP
en-wikipedia-org-4107	1893	2	 	  	_SP
en-wikipedia-org-4107	1893	3	15860375	15860375	CD
en-wikipedia-org-4107	1893	4	.	.	.
en-wikipedia-org-4107	1894	1	^	^	FW
en-wikipedia-org-4107	1894	2	"	"	``
en-wikipedia-org-4107	1894	3	Determination	determination	NN
en-wikipedia-org-4107	1894	4	That	that	DT
en-wikipedia-org-4107	1894	5	Delcobese	Delcobese	NNP
en-wikipedia-org-4107	1894	6	(	(	-LRB-
en-wikipedia-org-4107	1894	7	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1894	8	Adipate	Adipate	NNP
en-wikipedia-org-4107	1894	9	,	,	,
en-wikipedia-org-4107	1894	10	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1894	11	Sulfate	Sulfate	NNP
en-wikipedia-org-4107	1894	12	,	,	,
en-wikipedia-org-4107	1894	13	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	1894	14	Adipate	Adipate	NNP
en-wikipedia-org-4107	1894	15	,	,	,
en-wikipedia-org-4107	1894	16	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	1894	17	Sulfate	Sulfate	NNP
en-wikipedia-org-4107	1894	18	)	)	-RRB-
en-wikipedia-org-4107	1894	19	Tablets	tablet	NNS
en-wikipedia-org-4107	1894	20	and	and	CC
en-wikipedia-org-4107	1894	21	Capsules	Capsules	NNPS
en-wikipedia-org-4107	1894	22	Were	be	VBD
en-wikipedia-org-4107	1894	23	Not	not	RB
en-wikipedia-org-4107	1894	24	Withdrawn	withdraw	VBN
en-wikipedia-org-4107	1894	25	From	from	IN
en-wikipedia-org-4107	1894	26	Sale	sale	NN
en-wikipedia-org-4107	1894	27	for	for	IN
en-wikipedia-org-4107	1894	28	Reasons	Reasons	NNPS
en-wikipedia-org-4107	1894	29	of	of	IN
en-wikipedia-org-4107	1894	30	Safety	Safety	NNP
en-wikipedia-org-4107	1894	31	or	or	CC
en-wikipedia-org-4107	1894	32	Effectiveness	Effectiveness	NNP
en-wikipedia-org-4107	1894	33	"	"	''
en-wikipedia-org-4107	1894	34	.	.	.
en-wikipedia-org-4107	1895	1	Federal	Federal	NNP
en-wikipedia-org-4107	1895	2	Register	Register	NNP
en-wikipedia-org-4107	1895	3	.	.	.
en-wikipedia-org-4107	1896	1	10	10	CD
en-wikipedia-org-4107	1896	2	November	November	NNP
en-wikipedia-org-4107	1896	3	2003	2003	CD
en-wikipedia-org-4107	1896	4	.	.	.
en-wikipedia-org-4107	1897	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1897	2	3	3	CD
en-wikipedia-org-4107	1897	3	January	January	NNP
en-wikipedia-org-4107	1897	4	2020	2020	CD
en-wikipedia-org-4107	1897	5	.	.	.
en-wikipedia-org-4107	1898	1	^	^	FW
en-wikipedia-org-4107	1898	2	"	"	``
en-wikipedia-org-4107	1898	3	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1898	4	Hydrochloride	Hydrochloride	NNP
en-wikipedia-org-4107	1898	5	"	"	''
en-wikipedia-org-4107	1898	6	.	.	.
en-wikipedia-org-4107	1899	1	Pubchem	Pubchem	NNP
en-wikipedia-org-4107	1899	2	Compound	Compound	NNP
en-wikipedia-org-4107	1899	3	Database	Database	NNP
en-wikipedia-org-4107	1899	4	.	.	.
en-wikipedia-org-4107	1900	1	United	United	NNP
en-wikipedia-org-4107	1900	2	States	States	NNP
en-wikipedia-org-4107	1900	3	National	National	NNP
en-wikipedia-org-4107	1900	4	Library	Library	NNP
en-wikipedia-org-4107	1900	5	of	of	IN
en-wikipedia-org-4107	1900	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	1900	7	 	  	_SP
en-wikipedia-org-4107	1900	8	–	–	:
en-wikipedia-org-4107	1900	9	National	National	NNP
en-wikipedia-org-4107	1900	10	Center	Center	NNP
en-wikipedia-org-4107	1900	11	for	for	IN
en-wikipedia-org-4107	1900	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	1900	13	Information	Information	NNP
en-wikipedia-org-4107	1900	14	.	.	.
en-wikipedia-org-4107	1901	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1901	2	8	8	CD
en-wikipedia-org-4107	1901	3	November	November	NNP
en-wikipedia-org-4107	1901	4	2013	2013	CD
en-wikipedia-org-4107	1901	5	.	.	.
en-wikipedia-org-4107	1902	1	^	^	FW
en-wikipedia-org-4107	1902	2	"	"	``
en-wikipedia-org-4107	1902	3	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1902	4	Phosphate	Phosphate	NNP
en-wikipedia-org-4107	1902	5	"	"	''
en-wikipedia-org-4107	1902	6	.	.	.
en-wikipedia-org-4107	1903	1	Pubchem	Pubchem	NNP
en-wikipedia-org-4107	1903	2	Compound	Compound	NNP
en-wikipedia-org-4107	1903	3	Database	Database	NNP
en-wikipedia-org-4107	1903	4	.	.	.
en-wikipedia-org-4107	1904	1	United	United	NNP
en-wikipedia-org-4107	1904	2	States	States	NNP
en-wikipedia-org-4107	1904	3	National	National	NNP
en-wikipedia-org-4107	1904	4	Library	Library	NNP
en-wikipedia-org-4107	1904	5	of	of	IN
en-wikipedia-org-4107	1904	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	1904	7	 	  	_SP
en-wikipedia-org-4107	1904	8	–	–	:
en-wikipedia-org-4107	1904	9	National	National	NNP
en-wikipedia-org-4107	1904	10	Center	Center	NNP
en-wikipedia-org-4107	1904	11	for	for	IN
en-wikipedia-org-4107	1904	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	1904	13	Information	Information	NNP
en-wikipedia-org-4107	1904	14	.	.	.
en-wikipedia-org-4107	1905	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1905	2	8	8	CD
en-wikipedia-org-4107	1905	3	November	November	NNP
en-wikipedia-org-4107	1905	4	2013	2013	CD
en-wikipedia-org-4107	1905	5	.	.	.
en-wikipedia-org-4107	1906	1	^	^	NNP
en-wikipedia-org-4107	1906	2	Cavallito	Cavallito	NNP
en-wikipedia-org-4107	1906	3	,	,	,
en-wikipedia-org-4107	1906	4	John	John	NNP
en-wikipedia-org-4107	1906	5	(	(	-LRB-
en-wikipedia-org-4107	1906	6	23	23	CD
en-wikipedia-org-4107	1906	7	August	August	NNP
en-wikipedia-org-4107	1906	8	1960	1960	CD
en-wikipedia-org-4107	1906	9	)	)	-RRB-
en-wikipedia-org-4107	1906	10	.	.	.
en-wikipedia-org-4107	1907	1	"	"	``
en-wikipedia-org-4107	1907	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1907	3	Tannate	Tannate	NNP
en-wikipedia-org-4107	1907	4	.	.	.
en-wikipedia-org-4107	1908	1	Patent	Patent	NNP
en-wikipedia-org-4107	1908	2	Application	application	NN
en-wikipedia-org-4107	1908	3	No	no	UH
en-wikipedia-org-4107	1908	4	.	.	.
en-wikipedia-org-4107	1909	1	2,950,309	2,950,309	CD
en-wikipedia-org-4107	1909	2	"	"	''
en-wikipedia-org-4107	1909	3	(	(	-LRB-
en-wikipedia-org-4107	1909	4	PDF	PDF	NNP
en-wikipedia-org-4107	1909	5	)	)	-RRB-
en-wikipedia-org-4107	1909	6	.	.	.
en-wikipedia-org-4107	1910	1	United	United	NNP
en-wikipedia-org-4107	1910	2	States	States	NNP
en-wikipedia-org-4107	1910	3	Patent	Patent	NNP
en-wikipedia-org-4107	1910	4	Office	Office	NNP
en-wikipedia-org-4107	1910	5	.	.	.
en-wikipedia-org-4107	1911	1	^	^	NN
en-wikipedia-org-4107	1911	2	Brussee	Brussee	NNP
en-wikipedia-org-4107	1911	3	J	J	NNP
en-wikipedia-org-4107	1911	4	,	,	,
en-wikipedia-org-4107	1911	5	Jansen	Jansen	NNP
en-wikipedia-org-4107	1911	6	AC	AC	NNP
en-wikipedia-org-4107	1911	7	(	(	-LRB-
en-wikipedia-org-4107	1911	8	May	May	NNP
en-wikipedia-org-4107	1911	9	1983	1983	CD
en-wikipedia-org-4107	1911	10	)	)	-RRB-
en-wikipedia-org-4107	1911	11	.	.	.
en-wikipedia-org-4107	1912	1	"	"	``
en-wikipedia-org-4107	1912	2	A	a	DT
en-wikipedia-org-4107	1912	3	highly	highly	RB
en-wikipedia-org-4107	1912	4	stereoselective	stereoselective	JJ
en-wikipedia-org-4107	1912	5	synthesis	synthesis	NN
en-wikipedia-org-4107	1912	6	of	of	IN
en-wikipedia-org-4107	1912	7	s(−)-[1,1'-binaphthalene]-2,2'-diol	s(−)-[1,1'-binaphthalene]-2,2'-diol	NNP
en-wikipedia-org-4107	1912	8	"	"	''
en-wikipedia-org-4107	1912	9	.	.	.
en-wikipedia-org-4107	1913	1	Tetrahedron	Tetrahedron	NNP
en-wikipedia-org-4107	1913	2	Letters	Letters	NNPS
en-wikipedia-org-4107	1913	3	.	.	.
en-wikipedia-org-4107	1914	1	24	24	CD
en-wikipedia-org-4107	1914	2	(	(	-LRB-
en-wikipedia-org-4107	1914	3	31	31	CD
en-wikipedia-org-4107	1914	4	)	)	-RRB-
en-wikipedia-org-4107	1914	5	:	:	:
en-wikipedia-org-4107	1914	6	3261–3262	3261–3262	CD
en-wikipedia-org-4107	1914	7	.	.	.
en-wikipedia-org-4107	1915	1	doi:10.1016	doi:10.1016	JJ
en-wikipedia-org-4107	1915	2	/	/	SYM
en-wikipedia-org-4107	1915	3	S0040	S0040	NNP
en-wikipedia-org-4107	1915	4	-	-	HYPH
en-wikipedia-org-4107	1915	5	4039(00)88151	4039(00)88151	NN
en-wikipedia-org-4107	1915	6	-	-	HYPH
en-wikipedia-org-4107	1915	7	4	4	CD
en-wikipedia-org-4107	1915	8	.	.	.
en-wikipedia-org-4107	1916	1	^	^	NNP
en-wikipedia-org-4107	1916	2	a	a	DT
en-wikipedia-org-4107	1916	3	b	b	NNP
en-wikipedia-org-4107	1916	4	Schep	Schep	NNP
en-wikipedia-org-4107	1916	5	LJ	LJ	NNP
en-wikipedia-org-4107	1916	6	,	,	,
en-wikipedia-org-4107	1916	7	Slaughter	Slaughter	NNP
en-wikipedia-org-4107	1916	8	RJ	RJ	NNP
en-wikipedia-org-4107	1916	9	,	,	,
en-wikipedia-org-4107	1916	10	Beasley	Beasley	NNP
en-wikipedia-org-4107	1916	11	DM	DM	NNP
en-wikipedia-org-4107	1916	12	(	(	-LRB-
en-wikipedia-org-4107	1916	13	August	August	NNP
en-wikipedia-org-4107	1916	14	2010	2010	CD
en-wikipedia-org-4107	1916	15	)	)	-RRB-
en-wikipedia-org-4107	1916	16	.	.	.
en-wikipedia-org-4107	1917	1	"	"	``
en-wikipedia-org-4107	1917	2	The	the	DT
en-wikipedia-org-4107	1917	3	clinical	clinical	JJ
en-wikipedia-org-4107	1917	4	toxicology	toxicology	NN
en-wikipedia-org-4107	1917	5	of	of	IN
en-wikipedia-org-4107	1917	6	metamfetamine	metamfetamine	NN
en-wikipedia-org-4107	1917	7	"	"	''
en-wikipedia-org-4107	1917	8	.	.	.
en-wikipedia-org-4107	1918	1	Clinical	Clinical	NNP
en-wikipedia-org-4107	1918	2	Toxicology	Toxicology	NNP
en-wikipedia-org-4107	1918	3	.	.	.
en-wikipedia-org-4107	1919	1	48	48	CD
en-wikipedia-org-4107	1919	2	(	(	-LRB-
en-wikipedia-org-4107	1919	3	7	7	CD
en-wikipedia-org-4107	1919	4	)	)	-RRB-
en-wikipedia-org-4107	1919	5	:	:	:
en-wikipedia-org-4107	1919	6	675–694	675–694	CD
en-wikipedia-org-4107	1919	7	.	.	.
en-wikipedia-org-4107	1920	1	doi:10.3109/15563650.2010.516752	doi:10.3109/15563650.2010.516752	NNP
en-wikipedia-org-4107	1920	2	.	.	.
en-wikipedia-org-4107	1921	1	ISSN	issn	NN
en-wikipedia-org-4107	1921	2	 	  	_SP
en-wikipedia-org-4107	1921	3	1556	1556	CD
en-wikipedia-org-4107	1921	4	-	-	SYM
en-wikipedia-org-4107	1921	5	3650	3650	CD
en-wikipedia-org-4107	1921	6	.	.	.
en-wikipedia-org-4107	1922	1	PMID	PMID	NNP
en-wikipedia-org-4107	1922	2	 	  	_SP
en-wikipedia-org-4107	1922	3	20849327	20849327	CD
en-wikipedia-org-4107	1922	4	.	.	.
en-wikipedia-org-4107	1923	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	1923	2	 	  	_SP
en-wikipedia-org-4107	1923	3	42588722	42588722	CD
en-wikipedia-org-4107	1923	4	.	.	.
en-wikipedia-org-4107	1924	1	^	^	NNP
en-wikipedia-org-4107	1924	2	Lillsunde	Lillsunde	NNP
en-wikipedia-org-4107	1924	3	P	P	NNP
en-wikipedia-org-4107	1924	4	,	,	,
en-wikipedia-org-4107	1924	5	Korte	Korte	NNP
en-wikipedia-org-4107	1924	6	T	T	NNP
en-wikipedia-org-4107	1924	7	(	(	-LRB-
en-wikipedia-org-4107	1924	8	March	March	NNP
en-wikipedia-org-4107	1924	9	1991	1991	CD
en-wikipedia-org-4107	1924	10	)	)	-RRB-
en-wikipedia-org-4107	1924	11	.	.	.
en-wikipedia-org-4107	1925	1	"	"	``
en-wikipedia-org-4107	1925	2	Determination	Determination	NNP
en-wikipedia-org-4107	1925	3	of	of	IN
en-wikipedia-org-4107	1925	4	ring-	ring-	NNP
en-wikipedia-org-4107	1925	5	and	and	CC
en-wikipedia-org-4107	1925	6	N	N	NNP
en-wikipedia-org-4107	1925	7	-	-	HYPH
en-wikipedia-org-4107	1925	8	substituted	substitute	VBN
en-wikipedia-org-4107	1925	9	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	1925	10	as	as	IN
en-wikipedia-org-4107	1925	11	heptafluorobutyryl	heptafluorobutyryl	NNP
en-wikipedia-org-4107	1925	12	derivatives	derivatives	NNP
en-wikipedia-org-4107	1925	13	"	"	''
en-wikipedia-org-4107	1925	14	.	.	.
en-wikipedia-org-4107	1926	1	Forensic	Forensic	NNP
en-wikipedia-org-4107	1926	2	Science	Science	NNP
en-wikipedia-org-4107	1926	3	International	International	NNP
en-wikipedia-org-4107	1926	4	.	.	.
en-wikipedia-org-4107	1927	1	49	49	CD
en-wikipedia-org-4107	1927	2	(	(	-LRB-
en-wikipedia-org-4107	1927	3	2	2	CD
en-wikipedia-org-4107	1927	4	)	)	-RRB-
en-wikipedia-org-4107	1927	5	:	:	:
en-wikipedia-org-4107	1927	6	205–213	205–213	CD
en-wikipedia-org-4107	1927	7	.	.	.
en-wikipedia-org-4107	1928	1	doi:10.1016/0379	doi:10.1016/0379	NNP
en-wikipedia-org-4107	1928	2	-	-	HYPH
en-wikipedia-org-4107	1928	3	0738(91)90081-s	0738(91)90081-s	CD
en-wikipedia-org-4107	1928	4	.	.	.
en-wikipedia-org-4107	1928	5	PMID	PMID	NNP
en-wikipedia-org-4107	1928	6	 	  	_SP
en-wikipedia-org-4107	1928	7	1855720	1855720	CD
en-wikipedia-org-4107	1928	8	.	.	.
en-wikipedia-org-4107	1929	1	^	^	NNP
en-wikipedia-org-4107	1929	2	a	a	DT
en-wikipedia-org-4107	1929	3	b	b	NN
en-wikipedia-org-4107	1929	4	c	c	NN
en-wikipedia-org-4107	1929	5	d	d	NN
en-wikipedia-org-4107	1929	6	"	"	``
en-wikipedia-org-4107	1929	7	Historical	historical	JJ
en-wikipedia-org-4107	1929	8	overview	overview	NN
en-wikipedia-org-4107	1929	9	of	of	IN
en-wikipedia-org-4107	1929	10	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	1929	11	"	"	''
en-wikipedia-org-4107	1929	12	.	.	.
en-wikipedia-org-4107	1930	1	Vermont	Vermont	NNP
en-wikipedia-org-4107	1930	2	Department	Department	NNP
en-wikipedia-org-4107	1930	3	of	of	IN
en-wikipedia-org-4107	1930	4	Health	Health	NNP
en-wikipedia-org-4107	1930	5	.	.	.
en-wikipedia-org-4107	1931	1	Government	Government	NNP
en-wikipedia-org-4107	1931	2	of	of	IN
en-wikipedia-org-4107	1931	3	Vermont	Vermont	NNP
en-wikipedia-org-4107	1931	4	.	.	.
en-wikipedia-org-4107	1932	1	Archived	archived	JJ
en-wikipedia-org-4107	1932	2	from	from	IN
en-wikipedia-org-4107	1932	3	the	the	DT
en-wikipedia-org-4107	1932	4	original	original	NN
en-wikipedia-org-4107	1932	5	on	on	IN
en-wikipedia-org-4107	1932	6	5	5	CD
en-wikipedia-org-4107	1932	7	October	October	NNP
en-wikipedia-org-4107	1932	8	2012	2012	CD
en-wikipedia-org-4107	1932	9	.	.	.
en-wikipedia-org-4107	1933	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1933	2	29	29	CD
en-wikipedia-org-4107	1933	3	January	January	NNP
en-wikipedia-org-4107	1933	4	2012	2012	CD
en-wikipedia-org-4107	1933	5	.	.	.
en-wikipedia-org-4107	1934	1	^	^	NNP
en-wikipedia-org-4107	1934	2	a	a	DT
en-wikipedia-org-4107	1934	3	b	b	NNP
en-wikipedia-org-4107	1934	4	c	c	NN
en-wikipedia-org-4107	1934	5	Allen	Allen	NNP
en-wikipedia-org-4107	1934	6	A	A	NNP
en-wikipedia-org-4107	1934	7	,	,	,
en-wikipedia-org-4107	1934	8	Ely	Ely	NNP
en-wikipedia-org-4107	1934	9	R	r	NN
en-wikipedia-org-4107	1934	10	(	(	-LRB-
en-wikipedia-org-4107	1934	11	April	April	NNP
en-wikipedia-org-4107	1934	12	2009	2009	CD
en-wikipedia-org-4107	1934	13	)	)	-RRB-
en-wikipedia-org-4107	1934	14	.	.	.
en-wikipedia-org-4107	1935	1	"	"	``
en-wikipedia-org-4107	1935	2	Review	review	NN
en-wikipedia-org-4107	1935	3	:	:	:
en-wikipedia-org-4107	1935	4	Synthetic	synthetic	JJ
en-wikipedia-org-4107	1935	5	Methods	method	NNS
en-wikipedia-org-4107	1935	6	for	for	IN
en-wikipedia-org-4107	1935	7	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1935	8	"	"	''
en-wikipedia-org-4107	1935	9	(	(	-LRB-
en-wikipedia-org-4107	1935	10	PDF	PDF	NNP
en-wikipedia-org-4107	1935	11	)	)	-RRB-
en-wikipedia-org-4107	1935	12	.	.	.
en-wikipedia-org-4107	1936	1	Crime	crime	NN
en-wikipedia-org-4107	1936	2	Scene	scene	NN
en-wikipedia-org-4107	1936	3	.	.	.
en-wikipedia-org-4107	1937	1	Northwest	Northwest	NNP
en-wikipedia-org-4107	1937	2	Association	Association	NNP
en-wikipedia-org-4107	1937	3	of	of	IN
en-wikipedia-org-4107	1937	4	Forensic	Forensic	NNP
en-wikipedia-org-4107	1937	5	Scientists	Scientists	NNPS
en-wikipedia-org-4107	1937	6	.	.	.
en-wikipedia-org-4107	1938	1	37	37	CD
en-wikipedia-org-4107	1938	2	(	(	-LRB-
en-wikipedia-org-4107	1938	3	2	2	CD
en-wikipedia-org-4107	1938	4	)	)	-RRB-
en-wikipedia-org-4107	1938	5	:	:	:
en-wikipedia-org-4107	1938	6	15–25	15–25	CD
en-wikipedia-org-4107	1938	7	.	.	.
en-wikipedia-org-4107	1939	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	1939	2	6	6	CD
en-wikipedia-org-4107	1939	3	December	December	NNP
en-wikipedia-org-4107	1939	4	2014	2014	CD
en-wikipedia-org-4107	1939	5	.	.	.
en-wikipedia-org-4107	1940	1	^	^	NNP
en-wikipedia-org-4107	1940	2	a	a	DT
en-wikipedia-org-4107	1940	3	b	b	NNP
en-wikipedia-org-4107	1940	4	c	c	NN
en-wikipedia-org-4107	1940	5	Allen	Allen	NNP
en-wikipedia-org-4107	1940	6	A	A	NNP
en-wikipedia-org-4107	1940	7	,	,	,
en-wikipedia-org-4107	1940	8	Cantrell	Cantrell	NNP
en-wikipedia-org-4107	1940	9	TS	TS	NNP
en-wikipedia-org-4107	1940	10	(	(	-LRB-
en-wikipedia-org-4107	1940	11	August	August	NNP
en-wikipedia-org-4107	1940	12	1989	1989	CD
en-wikipedia-org-4107	1940	13	)	)	-RRB-
en-wikipedia-org-4107	1940	14	.	.	.
en-wikipedia-org-4107	1941	1	"	"	``
en-wikipedia-org-4107	1941	2	Synthetic	synthetic	JJ
en-wikipedia-org-4107	1941	3	reductions	reduction	NNS
en-wikipedia-org-4107	1941	4	in	in	IN
en-wikipedia-org-4107	1941	5	clandestine	clandestine	JJ
en-wikipedia-org-4107	1941	6	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1941	7	and	and	CC
en-wikipedia-org-4107	1941	8	methamphetamine	methamphetamine	JJ
en-wikipedia-org-4107	1941	9	laboratories	laboratory	NNS
en-wikipedia-org-4107	1941	10	:	:	:
en-wikipedia-org-4107	1941	11	A	a	DT
en-wikipedia-org-4107	1941	12	review	review	NN
en-wikipedia-org-4107	1941	13	"	"	''
en-wikipedia-org-4107	1941	14	.	.	.
en-wikipedia-org-4107	1942	1	Forensic	Forensic	NNP
en-wikipedia-org-4107	1942	2	Science	Science	NNP
en-wikipedia-org-4107	1942	3	International	International	NNP
en-wikipedia-org-4107	1942	4	.	.	.
en-wikipedia-org-4107	1943	1	42	42	CD
en-wikipedia-org-4107	1943	2	(	(	-LRB-
en-wikipedia-org-4107	1943	3	3	3	CD
en-wikipedia-org-4107	1943	4	)	)	-RRB-
en-wikipedia-org-4107	1943	5	:	:	:
en-wikipedia-org-4107	1943	6	183–199	183–199	CD
en-wikipedia-org-4107	1943	7	.	.	.
en-wikipedia-org-4107	1944	1	doi:10.1016/0379	doi:10.1016/0379	NNP
en-wikipedia-org-4107	1944	2	-	-	HYPH
en-wikipedia-org-4107	1944	3	0738(89)90086	0738(89)90086	NNP
en-wikipedia-org-4107	1944	4	-	-	HYPH
en-wikipedia-org-4107	1944	5	8	8	CD
en-wikipedia-org-4107	1944	6	.	.	.
en-wikipedia-org-4107	1945	1	^	^	NNP
en-wikipedia-org-4107	1945	2	a	a	DT
en-wikipedia-org-4107	1945	3	b	b	NN
en-wikipedia-org-4107	1945	4	c	c	NN
en-wikipedia-org-4107	1945	5	d	d	NN
en-wikipedia-org-4107	1945	6	"	"	``
en-wikipedia-org-4107	1945	7	Recommended	recommend	VBN
en-wikipedia-org-4107	1945	8	methods	method	NNS
en-wikipedia-org-4107	1945	9	of	of	IN
en-wikipedia-org-4107	1945	10	the	the	DT
en-wikipedia-org-4107	1945	11	identification	identification	NN
en-wikipedia-org-4107	1945	12	and	and	CC
en-wikipedia-org-4107	1945	13	analysis	analysis	NN
en-wikipedia-org-4107	1945	14	of	of	IN
en-wikipedia-org-4107	1945	15	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1945	16	,	,	,
en-wikipedia-org-4107	1945	17	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	1945	18	,	,	,
en-wikipedia-org-4107	1945	19	and	and	CC
en-wikipedia-org-4107	1945	20	their	-PRON-	PRP$
en-wikipedia-org-4107	1945	21	ring	ring	NN
en-wikipedia-org-4107	1945	22	-	-	HYPH
en-wikipedia-org-4107	1945	23	substituted	substitute	VBN
en-wikipedia-org-4107	1945	24	analogues	analogue	NNS
en-wikipedia-org-4107	1945	25	in	in	IN
en-wikipedia-org-4107	1945	26	seized	seize	VBN
en-wikipedia-org-4107	1945	27	materials	material	NNS
en-wikipedia-org-4107	1945	28	"	"	''
en-wikipedia-org-4107	1945	29	(	(	-LRB-
en-wikipedia-org-4107	1945	30	PDF	PDF	NNP
en-wikipedia-org-4107	1945	31	)	)	-RRB-
en-wikipedia-org-4107	1945	32	.	.	.
en-wikipedia-org-4107	1946	1	United	United	NNP
en-wikipedia-org-4107	1946	2	Nations	Nations	NNP
en-wikipedia-org-4107	1946	3	Office	Office	NNP
en-wikipedia-org-4107	1946	4	on	on	IN
en-wikipedia-org-4107	1946	5	Drugs	Drugs	NNPS
en-wikipedia-org-4107	1946	6	and	and	CC
en-wikipedia-org-4107	1946	7	Crime	Crime	NNP
en-wikipedia-org-4107	1946	8	.	.	.
en-wikipedia-org-4107	1947	1	United	United	NNP
en-wikipedia-org-4107	1947	2	Nations	Nations	NNP
en-wikipedia-org-4107	1947	3	.	.	.
en-wikipedia-org-4107	1948	1	2006	2006	CD
en-wikipedia-org-4107	1948	2	.	.	.
en-wikipedia-org-4107	1948	3	pp	pp	NNP
en-wikipedia-org-4107	1948	4	.	.	.
en-wikipedia-org-4107	1949	1	9–12	9–12	CD
en-wikipedia-org-4107	1949	2	.	.	.
en-wikipedia-org-4107	1950	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	1950	2	14	14	CD
en-wikipedia-org-4107	1950	3	October	October	NNP
en-wikipedia-org-4107	1950	4	2013	2013	CD
en-wikipedia-org-4107	1950	5	.	.	.
en-wikipedia-org-4107	1951	1	^	^	NNP
en-wikipedia-org-4107	1951	2	Pollard	Pollard	NNP
en-wikipedia-org-4107	1951	3	CB	CB	NNP
en-wikipedia-org-4107	1951	4	,	,	,
en-wikipedia-org-4107	1951	5	Young	Young	NNP
en-wikipedia-org-4107	1951	6	DC	DC	NNP
en-wikipedia-org-4107	1951	7	(	(	-LRB-
en-wikipedia-org-4107	1951	8	May	May	NNP
en-wikipedia-org-4107	1951	9	1951	1951	CD
en-wikipedia-org-4107	1951	10	)	)	-RRB-
en-wikipedia-org-4107	1951	11	.	.	.
en-wikipedia-org-4107	1952	1	"	"	``
en-wikipedia-org-4107	1952	2	The	the	DT
en-wikipedia-org-4107	1952	3	Mechanism	Mechanism	NNP
en-wikipedia-org-4107	1952	4	of	of	IN
en-wikipedia-org-4107	1952	5	the	the	DT
en-wikipedia-org-4107	1952	6	Leuckart	Leuckart	NNP
en-wikipedia-org-4107	1952	7	Reaction	Reaction	NNP
en-wikipedia-org-4107	1952	8	"	"	''
en-wikipedia-org-4107	1952	9	.	.	.
en-wikipedia-org-4107	1953	1	The	the	DT
en-wikipedia-org-4107	1953	2	Journal	Journal	NNP
en-wikipedia-org-4107	1953	3	of	of	IN
en-wikipedia-org-4107	1953	4	Organic	Organic	NNP
en-wikipedia-org-4107	1953	5	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	1953	6	.	.	.
en-wikipedia-org-4107	1954	1	16	16	CD
en-wikipedia-org-4107	1954	2	(	(	-LRB-
en-wikipedia-org-4107	1954	3	5	5	CD
en-wikipedia-org-4107	1954	4	)	)	-RRB-
en-wikipedia-org-4107	1954	5	:	:	:
en-wikipedia-org-4107	1954	6	661–672	661–672	CD
en-wikipedia-org-4107	1954	7	.	.	.
en-wikipedia-org-4107	1955	1	doi:10.1021	doi:10.1021	LS
en-wikipedia-org-4107	1955	2	/	/	SYM
en-wikipedia-org-4107	1955	3	jo01145a001	jo01145a001	NNP
en-wikipedia-org-4107	1955	4	.	.	.
en-wikipedia-org-4107	1956	1	^	^	NNP
en-wikipedia-org-4107	1956	2	US	US	NNP
en-wikipedia-org-4107	1956	3	patent	patent	NN
en-wikipedia-org-4107	1956	4	2276508	2276508	CD
en-wikipedia-org-4107	1956	5	,	,	,
en-wikipedia-org-4107	1956	6	Nabenhauer	Nabenhauer	NNP
en-wikipedia-org-4107	1956	7	FP	FP	NNP
en-wikipedia-org-4107	1956	8	,	,	,
en-wikipedia-org-4107	1956	9	"	"	''
en-wikipedia-org-4107	1956	10	Method	method	NN
en-wikipedia-org-4107	1956	11	for	for	IN
en-wikipedia-org-4107	1956	12	the	the	DT
en-wikipedia-org-4107	1956	13	separation	separation	NN
en-wikipedia-org-4107	1956	14	of	of	IN
en-wikipedia-org-4107	1956	15	optically	optically	RB
en-wikipedia-org-4107	1956	16	active	active	JJ
en-wikipedia-org-4107	1956	17	alpha	alpha	NN
en-wikipedia-org-4107	1956	18	-	-	HYPH
en-wikipedia-org-4107	1956	19	methylphenethylamine	methylphenethylamine	NN
en-wikipedia-org-4107	1956	20	"	"	''
en-wikipedia-org-4107	1956	21	,	,	,
en-wikipedia-org-4107	1956	22	published	publish	VBD
en-wikipedia-org-4107	1956	23	17	17	CD
en-wikipedia-org-4107	1956	24	March	March	NNP
en-wikipedia-org-4107	1956	25	1942	1942	CD
en-wikipedia-org-4107	1956	26	,	,	,
en-wikipedia-org-4107	1956	27	assigned	assign	VBN
en-wikipedia-org-4107	1956	28	to	to	IN
en-wikipedia-org-4107	1956	29	Smith	Smith	NNP
en-wikipedia-org-4107	1956	30	Kline	Kline	NNP
en-wikipedia-org-4107	1956	31	French	French	NNP
en-wikipedia-org-4107	1956	32	  	  	_SP
en-wikipedia-org-4107	1956	33	^	^	NN
en-wikipedia-org-4107	1956	34	a	a	DT
en-wikipedia-org-4107	1956	35	b	b	NNP
en-wikipedia-org-4107	1956	36	Gray	Gray	NNP
en-wikipedia-org-4107	1956	37	DL	DL	NNP
en-wikipedia-org-4107	1956	38	(	(	-LRB-
en-wikipedia-org-4107	1956	39	2007	2007	CD
en-wikipedia-org-4107	1956	40	)	)	-RRB-
en-wikipedia-org-4107	1956	41	.	.	.
en-wikipedia-org-4107	1957	1	"	"	``
en-wikipedia-org-4107	1957	2	Approved	approved	JJ
en-wikipedia-org-4107	1957	3	Treatments	treatment	NNS
en-wikipedia-org-4107	1957	4	for	for	IN
en-wikipedia-org-4107	1957	5	Attention	attention	NN
en-wikipedia-org-4107	1957	6	Deficit	Deficit	NNP
en-wikipedia-org-4107	1957	7	Hyperactivity	Hyperactivity	NNP
en-wikipedia-org-4107	1957	8	Disorder	Disorder	NNP
en-wikipedia-org-4107	1957	9	:	:	:
en-wikipedia-org-4107	1957	10	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	1957	11	(	(	-LRB-
en-wikipedia-org-4107	1957	12	Adderall	Adderall	NNP
en-wikipedia-org-4107	1957	13	)	)	-RRB-
en-wikipedia-org-4107	1957	14	,	,	,
en-wikipedia-org-4107	1957	15	Methylphenidate	Methylphenidate	NNP
en-wikipedia-org-4107	1957	16	(	(	-LRB-
en-wikipedia-org-4107	1957	17	Ritalin	Ritalin	NNP
en-wikipedia-org-4107	1957	18	)	)	-RRB-
en-wikipedia-org-4107	1957	19	,	,	,
en-wikipedia-org-4107	1957	20	and	and	CC
en-wikipedia-org-4107	1957	21	Atomoxetine	Atomoxetine	NNP
en-wikipedia-org-4107	1957	22	(	(	-LRB-
en-wikipedia-org-4107	1957	23	Straterra	Straterra	NNP
en-wikipedia-org-4107	1957	24	)	)	-RRB-
en-wikipedia-org-4107	1957	25	"	"	''
en-wikipedia-org-4107	1957	26	.	.	.
en-wikipedia-org-4107	1958	1	In	in	IN
en-wikipedia-org-4107	1958	2	Johnson	Johnson	NNP
en-wikipedia-org-4107	1958	3	DS	DS	NNP
en-wikipedia-org-4107	1958	4	,	,	,
en-wikipedia-org-4107	1958	5	Li	Li	NNP
en-wikipedia-org-4107	1958	6	JJ	JJ	NNP
en-wikipedia-org-4107	1958	7	(	(	-LRB-
en-wikipedia-org-4107	1958	8	eds	eds	NNP
en-wikipedia-org-4107	1958	9	.	.	.
en-wikipedia-org-4107	1958	10	)	)	-RRB-
en-wikipedia-org-4107	1958	11	.	.	.
en-wikipedia-org-4107	1959	1	The	the	DT
en-wikipedia-org-4107	1959	2	Art	Art	NNP
en-wikipedia-org-4107	1959	3	of	of	IN
en-wikipedia-org-4107	1959	4	Drug	Drug	NNP
en-wikipedia-org-4107	1959	5	Synthesis	Synthesis	NNP
en-wikipedia-org-4107	1959	6	.	.	.
en-wikipedia-org-4107	1960	1	New	New	NNP
en-wikipedia-org-4107	1960	2	York	York	NNP
en-wikipedia-org-4107	1960	3	,	,	,
en-wikipedia-org-4107	1960	4	USA	USA	NNP
en-wikipedia-org-4107	1960	5	:	:	:
en-wikipedia-org-4107	1960	6	Wiley	Wiley	NNP
en-wikipedia-org-4107	1960	7	-	-	HYPH
en-wikipedia-org-4107	1960	8	Interscience	Interscience	NNP
en-wikipedia-org-4107	1960	9	.	.	.
en-wikipedia-org-4107	1961	1	p.	p.	NN
en-wikipedia-org-4107	1961	2	 	  	_SP
en-wikipedia-org-4107	1961	3	247	247	CD
en-wikipedia-org-4107	1961	4	.	.	.
en-wikipedia-org-4107	1962	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	1962	2	 	  	_SP
en-wikipedia-org-4107	1962	3	9780471752158	9780471752158	CD
en-wikipedia-org-4107	1962	4	.	.	.
en-wikipedia-org-4107	1963	1	^	^	NNP
en-wikipedia-org-4107	1963	2	Patrick	Patrick	NNP
en-wikipedia-org-4107	1963	3	TM	TM	NNP
en-wikipedia-org-4107	1963	4	,	,	,
en-wikipedia-org-4107	1963	5	McBee	McBee	NNP
en-wikipedia-org-4107	1963	6	ET	ET	NNP
en-wikipedia-org-4107	1963	7	,	,	,
en-wikipedia-org-4107	1963	8	Hass	Hass	NNP
en-wikipedia-org-4107	1963	9	HB	HB	NNP
en-wikipedia-org-4107	1963	10	(	(	-LRB-
en-wikipedia-org-4107	1963	11	June	June	NNP
en-wikipedia-org-4107	1963	12	1946	1946	CD
en-wikipedia-org-4107	1963	13	)	)	-RRB-
en-wikipedia-org-4107	1963	14	.	.	.
en-wikipedia-org-4107	1964	1	"	"	``
en-wikipedia-org-4107	1964	2	Synthesis	Synthesis	NNP
en-wikipedia-org-4107	1964	3	of	of	IN
en-wikipedia-org-4107	1964	4	arylpropylamines	arylpropylamine	NNS
en-wikipedia-org-4107	1964	5	;	;	:
en-wikipedia-org-4107	1964	6	from	from	IN
en-wikipedia-org-4107	1964	7	allyl	allyl	NNP
en-wikipedia-org-4107	1964	8	chloride	chloride	NNP
en-wikipedia-org-4107	1964	9	"	"	''
en-wikipedia-org-4107	1964	10	.	.	.
en-wikipedia-org-4107	1965	1	Journal	Journal	NNP
en-wikipedia-org-4107	1965	2	of	of	IN
en-wikipedia-org-4107	1965	3	the	the	DT
en-wikipedia-org-4107	1965	4	American	American	NNP
en-wikipedia-org-4107	1965	5	Chemical	Chemical	NNP
en-wikipedia-org-4107	1965	6	Society	Society	NNP
en-wikipedia-org-4107	1965	7	.	.	.
en-wikipedia-org-4107	1966	1	68	68	CD
en-wikipedia-org-4107	1966	2	(	(	-LRB-
en-wikipedia-org-4107	1966	3	6	6	CD
en-wikipedia-org-4107	1966	4	)	)	-RRB-
en-wikipedia-org-4107	1966	5	:	:	:
en-wikipedia-org-4107	1966	6	1009–1011	1009–1011	CD
en-wikipedia-org-4107	1966	7	.	.	.
en-wikipedia-org-4107	1967	1	doi:10.1021	doi:10.1021	LS
en-wikipedia-org-4107	1967	2	/	/	SYM
en-wikipedia-org-4107	1967	3	ja01210a032	ja01210a032	NNP
en-wikipedia-org-4107	1967	4	.	.	.
en-wikipedia-org-4107	1968	1	PMID	PMID	NNP
en-wikipedia-org-4107	1968	2	 	  	_SP
en-wikipedia-org-4107	1968	3	20985610	20985610	CD
en-wikipedia-org-4107	1968	4	.	.	.
en-wikipedia-org-4107	1969	1	^	^	NNP
en-wikipedia-org-4107	1969	2	Ritter	Ritter	NNP
en-wikipedia-org-4107	1969	3	JJ	JJ	NNP
en-wikipedia-org-4107	1969	4	,	,	,
en-wikipedia-org-4107	1969	5	Kalish	Kalish	NNP
en-wikipedia-org-4107	1969	6	J	J	NNP
en-wikipedia-org-4107	1969	7	(	(	-LRB-
en-wikipedia-org-4107	1969	8	December	December	NNP
en-wikipedia-org-4107	1969	9	1948	1948	CD
en-wikipedia-org-4107	1969	10	)	)	-RRB-
en-wikipedia-org-4107	1969	11	.	.	.
en-wikipedia-org-4107	1970	1	"	"	``
en-wikipedia-org-4107	1970	2	A	a	DT
en-wikipedia-org-4107	1970	3	new	new	JJ
en-wikipedia-org-4107	1970	4	reaction	reaction	NN
en-wikipedia-org-4107	1970	5	of	of	IN
en-wikipedia-org-4107	1970	6	nitriles	nitrile	NNS
en-wikipedia-org-4107	1970	7	;	;	:
en-wikipedia-org-4107	1970	8	synthesis	synthesis	NN
en-wikipedia-org-4107	1970	9	of	of	IN
en-wikipedia-org-4107	1970	10	t	t	NN
en-wikipedia-org-4107	1970	11	-	-	HYPH
en-wikipedia-org-4107	1970	12	carbinamines	carbinamines	NNP
en-wikipedia-org-4107	1970	13	"	"	''
en-wikipedia-org-4107	1970	14	.	.	.
en-wikipedia-org-4107	1971	1	Journal	Journal	NNP
en-wikipedia-org-4107	1971	2	of	of	IN
en-wikipedia-org-4107	1971	3	the	the	DT
en-wikipedia-org-4107	1971	4	American	American	NNP
en-wikipedia-org-4107	1971	5	Chemical	Chemical	NNP
en-wikipedia-org-4107	1971	6	Society	Society	NNP
en-wikipedia-org-4107	1971	7	.	.	.
en-wikipedia-org-4107	1972	1	70	70	CD
en-wikipedia-org-4107	1972	2	(	(	-LRB-
en-wikipedia-org-4107	1972	3	12	12	CD
en-wikipedia-org-4107	1972	4	)	)	-RRB-
en-wikipedia-org-4107	1972	5	:	:	:
en-wikipedia-org-4107	1972	6	4048–4050	4048–4050	CD
en-wikipedia-org-4107	1972	7	.	.	.
en-wikipedia-org-4107	1973	1	doi:10.1021	doi:10.1021	LS
en-wikipedia-org-4107	1973	2	/	/	SYM
en-wikipedia-org-4107	1973	3	ja01192a023	ja01192a023	NNP
en-wikipedia-org-4107	1973	4	.	.	.
en-wikipedia-org-4107	1974	1	PMID	PMID	NNP
en-wikipedia-org-4107	1974	2	 	  	_SP
en-wikipedia-org-4107	1974	3	18105933	18105933	CD
en-wikipedia-org-4107	1974	4	.	.	.
en-wikipedia-org-4107	1975	1	^	^	NNP
en-wikipedia-org-4107	1975	2	Krimen	Krimen	NNP
en-wikipedia-org-4107	1975	3	LI	LI	NNP
en-wikipedia-org-4107	1975	4	,	,	,
en-wikipedia-org-4107	1975	5	Cota	Cota	NNP
en-wikipedia-org-4107	1975	6	DJ	DJ	NNP
en-wikipedia-org-4107	1975	7	(	(	-LRB-
en-wikipedia-org-4107	1975	8	March	March	NNP
en-wikipedia-org-4107	1975	9	2011	2011	CD
en-wikipedia-org-4107	1975	10	)	)	-RRB-
en-wikipedia-org-4107	1975	11	.	.	.
en-wikipedia-org-4107	1976	1	"	"	``
en-wikipedia-org-4107	1976	2	The	the	DT
en-wikipedia-org-4107	1976	3	Ritter	Ritter	NNP
en-wikipedia-org-4107	1976	4	Reaction	Reaction	NNP
en-wikipedia-org-4107	1976	5	"	"	''
en-wikipedia-org-4107	1976	6	.	.	.
en-wikipedia-org-4107	1977	1	Organic	Organic	NNP
en-wikipedia-org-4107	1977	2	Reactions	Reactions	NNPS
en-wikipedia-org-4107	1977	3	.	.	.
en-wikipedia-org-4107	1978	1	17	17	CD
en-wikipedia-org-4107	1978	2	.	.	.
en-wikipedia-org-4107	1978	3	p.	p.	NN
en-wikipedia-org-4107	1978	4	 	  	_SP
en-wikipedia-org-4107	1978	5	216	216	CD
en-wikipedia-org-4107	1978	6	.	.	.
en-wikipedia-org-4107	1978	7	doi:10.1002/0471264180.or017.03	doi:10.1002/0471264180.or017.03	CD
en-wikipedia-org-4107	1978	8	.	.	.
en-wikipedia-org-4107	1979	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	1979	2	 	  	_SP
en-wikipedia-org-4107	1979	3	9780471264187	9780471264187	CD
en-wikipedia-org-4107	1979	4	.	.	.
en-wikipedia-org-4107	1980	1	^	^	NNP
en-wikipedia-org-4107	1980	2	US	US	NNP
en-wikipedia-org-4107	1980	3	patent	patent	NN
en-wikipedia-org-4107	1980	4	2413493	2413493	CD
en-wikipedia-org-4107	1980	5	,	,	,
en-wikipedia-org-4107	1980	6	Bitler	Bitler	NNP
en-wikipedia-org-4107	1980	7	WP	WP	NNP
en-wikipedia-org-4107	1980	8	,	,	,
en-wikipedia-org-4107	1980	9	Flisik	Flisik	NNP
en-wikipedia-org-4107	1980	10	AC	AC	NNP
en-wikipedia-org-4107	1980	11	,	,	,
en-wikipedia-org-4107	1980	12	Leonard	Leonard	NNP
en-wikipedia-org-4107	1980	13	N	N	NNP
en-wikipedia-org-4107	1980	14	,	,	,
en-wikipedia-org-4107	1980	15	"	"	''
en-wikipedia-org-4107	1980	16	Synthesis	synthesis	NN
en-wikipedia-org-4107	1980	17	of	of	IN
en-wikipedia-org-4107	1980	18	isomer	isomer	NN
en-wikipedia-org-4107	1980	19	-	-	HYPH
en-wikipedia-org-4107	1980	20	free	free	JJ
en-wikipedia-org-4107	1980	21	benzyl	benzyl	NNP
en-wikipedia-org-4107	1980	22	methyl	methyl	NN
en-wikipedia-org-4107	1980	23	acetoacetic	acetoacetic	JJ
en-wikipedia-org-4107	1980	24	methyl	methyl	NN
en-wikipedia-org-4107	1980	25	ester	ester	NN
en-wikipedia-org-4107	1980	26	"	"	''
en-wikipedia-org-4107	1980	27	,	,	,
en-wikipedia-org-4107	1980	28	published	publish	VBD
en-wikipedia-org-4107	1980	29	31	31	CD
en-wikipedia-org-4107	1980	30	December	December	NNP
en-wikipedia-org-4107	1980	31	1946	1946	CD
en-wikipedia-org-4107	1980	32	,	,	,
en-wikipedia-org-4107	1980	33	assigned	assign	VBN
en-wikipedia-org-4107	1980	34	to	to	IN
en-wikipedia-org-4107	1980	35	Kay	Kay	NNP
en-wikipedia-org-4107	1980	36	Fries	Fries	NNP
en-wikipedia-org-4107	1980	37	Chemicals	Chemicals	NNP
en-wikipedia-org-4107	1980	38	Inc.	Inc.	NNP
en-wikipedia-org-4107	1980	39	  	  	_SP
en-wikipedia-org-4107	1980	40	^	^	NN
en-wikipedia-org-4107	1980	41	Collins	Collins	NNP
en-wikipedia-org-4107	1980	42	M	M	NNP
en-wikipedia-org-4107	1980	43	,	,	,
en-wikipedia-org-4107	1980	44	Salouros	Salouros	NNP
en-wikipedia-org-4107	1980	45	H	H	NNP
en-wikipedia-org-4107	1980	46	,	,	,
en-wikipedia-org-4107	1980	47	Cawley	Cawley	NNP
en-wikipedia-org-4107	1980	48	AT	AT	NNP
en-wikipedia-org-4107	1980	49	,	,	,
en-wikipedia-org-4107	1980	50	Robertson	Robertson	NNP
en-wikipedia-org-4107	1980	51	J	J	NNP
en-wikipedia-org-4107	1980	52	,	,	,
en-wikipedia-org-4107	1980	53	Heagney	Heagney	NNP
en-wikipedia-org-4107	1980	54	AC	AC	NNP
en-wikipedia-org-4107	1980	55	,	,	,
en-wikipedia-org-4107	1980	56	Arenas	Arenas	NNP
en-wikipedia-org-4107	1980	57	-	-	:
en-wikipedia-org-4107	1980	58	Queralt	Queralt	NNP
en-wikipedia-org-4107	1980	59	A	A	NNP
en-wikipedia-org-4107	1980	60	(	(	-LRB-
en-wikipedia-org-4107	1980	61	June	June	NNP
en-wikipedia-org-4107	1980	62	2010	2010	CD
en-wikipedia-org-4107	1980	63	)	)	-RRB-
en-wikipedia-org-4107	1980	64	.	.	.
en-wikipedia-org-4107	1981	1	"	"	``
en-wikipedia-org-4107	1981	2	δ13C	δ13C	NNP
en-wikipedia-org-4107	1981	3	and	and	CC
en-wikipedia-org-4107	1981	4	δ2H	δ2h	NN
en-wikipedia-org-4107	1981	5	isotope	isotope	NN
en-wikipedia-org-4107	1981	6	ratios	ratio	NNS
en-wikipedia-org-4107	1981	7	in	in	IN
en-wikipedia-org-4107	1981	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1981	9	synthesized	synthesize	VBN
en-wikipedia-org-4107	1981	10	from	from	IN
en-wikipedia-org-4107	1981	11	benzaldehyde	benzaldehyde	NN
en-wikipedia-org-4107	1981	12	and	and	CC
en-wikipedia-org-4107	1981	13	nitroethane	nitroethane	NN
en-wikipedia-org-4107	1981	14	"	"	''
en-wikipedia-org-4107	1981	15	.	.	.
en-wikipedia-org-4107	1982	1	Rapid	Rapid	NNP
en-wikipedia-org-4107	1982	2	Communications	Communications	NNP
en-wikipedia-org-4107	1982	3	in	in	IN
en-wikipedia-org-4107	1982	4	Mass	Mass	NNP
en-wikipedia-org-4107	1982	5	Spectrometry	Spectrometry	NNP
en-wikipedia-org-4107	1982	6	.	.	.
en-wikipedia-org-4107	1983	1	24	24	CD
en-wikipedia-org-4107	1983	2	(	(	-LRB-
en-wikipedia-org-4107	1983	3	11	11	CD
en-wikipedia-org-4107	1983	4	)	)	-RRB-
en-wikipedia-org-4107	1983	5	:	:	:
en-wikipedia-org-4107	1983	6	1653–1658	1653–1658	CD
en-wikipedia-org-4107	1983	7	.	.	.
en-wikipedia-org-4107	1984	1	doi:10.1002	doi:10.1002	NNP
en-wikipedia-org-4107	1984	2	/	/	SYM
en-wikipedia-org-4107	1984	3	rcm.4563	rcm.4563	NNP
en-wikipedia-org-4107	1984	4	.	.	.
en-wikipedia-org-4107	1985	1	PMID	PMID	NNP
en-wikipedia-org-4107	1985	2	 	  	_SP
en-wikipedia-org-4107	1985	3	20486262	20486262	CD
en-wikipedia-org-4107	1985	4	.	.	.
en-wikipedia-org-4107	1986	1	^	^	NNP
en-wikipedia-org-4107	1986	2	Kraemer	Kraemer	NNP
en-wikipedia-org-4107	1986	3	T	T	NNP
en-wikipedia-org-4107	1986	4	,	,	,
en-wikipedia-org-4107	1986	5	Maurer	Maurer	NNP
en-wikipedia-org-4107	1986	6	HH	HH	NNP
en-wikipedia-org-4107	1986	7	(	(	-LRB-
en-wikipedia-org-4107	1986	8	August	August	NNP
en-wikipedia-org-4107	1986	9	1998	1998	CD
en-wikipedia-org-4107	1986	10	)	)	-RRB-
en-wikipedia-org-4107	1986	11	.	.	.
en-wikipedia-org-4107	1987	1	"	"	``
en-wikipedia-org-4107	1987	2	Determination	Determination	NNP
en-wikipedia-org-4107	1987	3	of	of	IN
en-wikipedia-org-4107	1987	4	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	1987	5	,	,	,
en-wikipedia-org-4107	1987	6	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	1987	7	and	and	CC
en-wikipedia-org-4107	1987	8	amphetamine	amphetamine	NN
en-wikipedia-org-4107	1987	9	-	-	HYPH
en-wikipedia-org-4107	1987	10	derived	derive	VBN
en-wikipedia-org-4107	1987	11	designer	designer	NN
en-wikipedia-org-4107	1987	12	drugs	drug	NNS
en-wikipedia-org-4107	1987	13	or	or	CC
en-wikipedia-org-4107	1987	14	medicaments	medicament	NNS
en-wikipedia-org-4107	1987	15	in	in	IN
en-wikipedia-org-4107	1987	16	blood	blood	NN
en-wikipedia-org-4107	1987	17	and	and	CC
en-wikipedia-org-4107	1987	18	urine	urine	NN
en-wikipedia-org-4107	1987	19	"	"	''
en-wikipedia-org-4107	1987	20	.	.	.
en-wikipedia-org-4107	1988	1	Journal	Journal	NNP
en-wikipedia-org-4107	1988	2	of	of	IN
en-wikipedia-org-4107	1988	3	Chromatography	Chromatography	NNP
en-wikipedia-org-4107	1988	4	B.	B.	NNP
en-wikipedia-org-4107	1989	1	713	713	CD
en-wikipedia-org-4107	1989	2	(	(	-LRB-
en-wikipedia-org-4107	1989	3	1	1	CD
en-wikipedia-org-4107	1989	4	)	)	-RRB-
en-wikipedia-org-4107	1989	5	:	:	:
en-wikipedia-org-4107	1989	6	163–187	163–187	CD
en-wikipedia-org-4107	1989	7	.	.	.
en-wikipedia-org-4107	1990	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	1990	2	/	/	SYM
en-wikipedia-org-4107	1990	3	S0378	S0378	NNP
en-wikipedia-org-4107	1990	4	-	-	HYPH
en-wikipedia-org-4107	1990	5	4347(97)00515-X.	4347(97)00515-X.	NNP
en-wikipedia-org-4107	1991	1	PMID	PMID	NNP
en-wikipedia-org-4107	1991	2	 	  	_SP
en-wikipedia-org-4107	1991	3	9700558	9700558	CD
en-wikipedia-org-4107	1991	4	.	.	.
en-wikipedia-org-4107	1992	1	^	^	NNP
en-wikipedia-org-4107	1992	2	Kraemer	Kraemer	NNP
en-wikipedia-org-4107	1992	3	T	T	NNP
en-wikipedia-org-4107	1992	4	,	,	,
en-wikipedia-org-4107	1992	5	Paul	Paul	NNP
en-wikipedia-org-4107	1992	6	LD	LD	NNP
en-wikipedia-org-4107	1992	7	(	(	-LRB-
en-wikipedia-org-4107	1992	8	August	August	NNP
en-wikipedia-org-4107	1992	9	2007	2007	CD
en-wikipedia-org-4107	1992	10	)	)	-RRB-
en-wikipedia-org-4107	1992	11	.	.	.
en-wikipedia-org-4107	1993	1	"	"	``
en-wikipedia-org-4107	1993	2	Bioanalytical	bioanalytical	JJ
en-wikipedia-org-4107	1993	3	procedures	procedure	NNS
en-wikipedia-org-4107	1993	4	for	for	IN
en-wikipedia-org-4107	1993	5	determination	determination	NN
en-wikipedia-org-4107	1993	6	of	of	IN
en-wikipedia-org-4107	1993	7	drugs	drug	NNS
en-wikipedia-org-4107	1993	8	of	of	IN
en-wikipedia-org-4107	1993	9	abuse	abuse	NN
en-wikipedia-org-4107	1993	10	in	in	IN
en-wikipedia-org-4107	1993	11	blood	blood	NN
en-wikipedia-org-4107	1993	12	"	"	''
en-wikipedia-org-4107	1993	13	.	.	.
en-wikipedia-org-4107	1994	1	Analytical	analytical	JJ
en-wikipedia-org-4107	1994	2	and	and	CC
en-wikipedia-org-4107	1994	3	Bioanalytical	Bioanalytical	NNP
en-wikipedia-org-4107	1994	4	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	1994	5	.	.	.
en-wikipedia-org-4107	1995	1	388	388	CD
en-wikipedia-org-4107	1995	2	(	(	-LRB-
en-wikipedia-org-4107	1995	3	7	7	CD
en-wikipedia-org-4107	1995	4	)	)	-RRB-
en-wikipedia-org-4107	1995	5	:	:	:
en-wikipedia-org-4107	1995	6	1415–1435	1415–1435	ADD
en-wikipedia-org-4107	1995	7	.	.	.
en-wikipedia-org-4107	1996	1	doi:10.1007	doi:10.1007	NNP
en-wikipedia-org-4107	1996	2	/	/	SYM
en-wikipedia-org-4107	1996	3	s00216	s00216	NNP
en-wikipedia-org-4107	1996	4	-	-	HYPH
en-wikipedia-org-4107	1996	5	007	007	CD
en-wikipedia-org-4107	1996	6	-	-	HYPH
en-wikipedia-org-4107	1996	7	1271	1271	CD
en-wikipedia-org-4107	1996	8	-	-	SYM
en-wikipedia-org-4107	1996	9	6	6	CD
en-wikipedia-org-4107	1996	10	.	.	.
en-wikipedia-org-4107	1997	1	PMID	PMID	NNP
en-wikipedia-org-4107	1997	2	 	  	_SP
en-wikipedia-org-4107	1997	3	17468860	17468860	CD
en-wikipedia-org-4107	1997	4	.	.	.
en-wikipedia-org-4107	1998	1	S2CID	S2CID	NNP
en-wikipedia-org-4107	1998	2	 	  	_SP
en-wikipedia-org-4107	1998	3	32917584	32917584	CD
en-wikipedia-org-4107	1998	4	.	.	.
en-wikipedia-org-4107	1999	1	^	^	NFP
en-wikipedia-org-4107	1999	2	Goldberger	Goldberger	NNP
en-wikipedia-org-4107	1999	3	BA	BA	NNP
en-wikipedia-org-4107	1999	4	,	,	,
en-wikipedia-org-4107	1999	5	Cone	Cone	NNP
en-wikipedia-org-4107	1999	6	EJ	EJ	NNP
en-wikipedia-org-4107	1999	7	(	(	-LRB-
en-wikipedia-org-4107	1999	8	July	July	NNP
en-wikipedia-org-4107	1999	9	1994	1994	CD
en-wikipedia-org-4107	1999	10	)	)	-RRB-
en-wikipedia-org-4107	1999	11	.	.	.
en-wikipedia-org-4107	2000	1	"	"	``
en-wikipedia-org-4107	2000	2	Confirmatory	confirmatory	JJ
en-wikipedia-org-4107	2000	3	tests	test	VBZ
en-wikipedia-org-4107	2000	4	for	for	IN
en-wikipedia-org-4107	2000	5	drugs	drug	NNS
en-wikipedia-org-4107	2000	6	in	in	IN
en-wikipedia-org-4107	2000	7	the	the	DT
en-wikipedia-org-4107	2000	8	workplace	workplace	NN
en-wikipedia-org-4107	2000	9	by	by	IN
en-wikipedia-org-4107	2000	10	gas	gas	NN
en-wikipedia-org-4107	2000	11	chromatography	chromatography	NN
en-wikipedia-org-4107	2000	12	-	-	HYPH
en-wikipedia-org-4107	2000	13	mass	mass	NN
en-wikipedia-org-4107	2000	14	spectrometry	spectrometry	NN
en-wikipedia-org-4107	2000	15	"	"	''
en-wikipedia-org-4107	2000	16	.	.	.
en-wikipedia-org-4107	2001	1	Journal	Journal	NNP
en-wikipedia-org-4107	2001	2	of	of	IN
en-wikipedia-org-4107	2001	3	Chromatography	Chromatography	NNP
en-wikipedia-org-4107	2001	4	A.	A.	NNP
en-wikipedia-org-4107	2002	1	674	674	CD
en-wikipedia-org-4107	2002	2	(	(	-LRB-
en-wikipedia-org-4107	2002	3	1–2	1–2	CD
en-wikipedia-org-4107	2002	4	)	)	-RRB-
en-wikipedia-org-4107	2002	5	:	:	:
en-wikipedia-org-4107	2002	6	73–86	73–86	LS
en-wikipedia-org-4107	2002	7	.	.	.
en-wikipedia-org-4107	2003	1	doi:10.1016/0021	doi:10.1016/0021	NNP
en-wikipedia-org-4107	2003	2	-	-	HYPH
en-wikipedia-org-4107	2003	3	9673(94)85218	9673(94)85218	NNP
en-wikipedia-org-4107	2003	4	-	-	HYPH
en-wikipedia-org-4107	2003	5	9	9	CD
en-wikipedia-org-4107	2003	6	.	.	.
en-wikipedia-org-4107	2004	1	PMID	PMID	NNP
en-wikipedia-org-4107	2004	2	 	  	_SP
en-wikipedia-org-4107	2004	3	8075776	8075776	CD
en-wikipedia-org-4107	2004	4	.	.	.
en-wikipedia-org-4107	2005	1	^	^	NNP
en-wikipedia-org-4107	2005	2	a	a	DT
en-wikipedia-org-4107	2005	3	b	b	NNP
en-wikipedia-org-4107	2005	4	"	"	``
en-wikipedia-org-4107	2005	5	Clinical	Clinical	NNP
en-wikipedia-org-4107	2005	6	Drug	Drug	NNP
en-wikipedia-org-4107	2005	7	Testing	testing	NN
en-wikipedia-org-4107	2005	8	in	in	IN
en-wikipedia-org-4107	2005	9	Primary	Primary	NNP
en-wikipedia-org-4107	2005	10	Care	Care	NNP
en-wikipedia-org-4107	2005	11	"	"	''
en-wikipedia-org-4107	2005	12	(	(	-LRB-
en-wikipedia-org-4107	2005	13	PDF	PDF	NNP
en-wikipedia-org-4107	2005	14	)	)	-RRB-
en-wikipedia-org-4107	2005	15	.	.	.
en-wikipedia-org-4107	2006	1	University	University	NNP
en-wikipedia-org-4107	2006	2	of	of	IN
en-wikipedia-org-4107	2006	3	Colorado	Colorado	NNP
en-wikipedia-org-4107	2006	4	Denver	Denver	NNP
en-wikipedia-org-4107	2006	5	.	.	.
en-wikipedia-org-4107	2007	1	Technical	Technical	NNP
en-wikipedia-org-4107	2007	2	Assistance	Assistance	NNP
en-wikipedia-org-4107	2007	3	Publication	Publication	NNP
en-wikipedia-org-4107	2007	4	Series	Series	NNP
en-wikipedia-org-4107	2007	5	32	32	CD
en-wikipedia-org-4107	2007	6	.	.	.
en-wikipedia-org-4107	2008	1	United	United	NNP
en-wikipedia-org-4107	2008	2	States	States	NNP
en-wikipedia-org-4107	2008	3	Department	Department	NNP
en-wikipedia-org-4107	2008	4	of	of	IN
en-wikipedia-org-4107	2008	5	Health	Health	NNP
en-wikipedia-org-4107	2008	6	and	and	CC
en-wikipedia-org-4107	2008	7	Human	Human	NNP
en-wikipedia-org-4107	2008	8	Services	Services	NNPS
en-wikipedia-org-4107	2008	9	 	  	_SP
en-wikipedia-org-4107	2008	10	–	–	:
en-wikipedia-org-4107	2008	11	Substance	Substance	NNP
en-wikipedia-org-4107	2008	12	Abuse	Abuse	NNP
en-wikipedia-org-4107	2008	13	and	and	CC
en-wikipedia-org-4107	2008	14	Mental	Mental	NNP
en-wikipedia-org-4107	2008	15	Health	Health	NNP
en-wikipedia-org-4107	2008	16	Services	Services	NNPS
en-wikipedia-org-4107	2008	17	Administration	Administration	NNP
en-wikipedia-org-4107	2008	18	.	.	.
en-wikipedia-org-4107	2009	1	2012	2012	CD
en-wikipedia-org-4107	2009	2	.	.	.
en-wikipedia-org-4107	2009	3	p.	p.	NN
en-wikipedia-org-4107	2009	4	 	  	_SP
en-wikipedia-org-4107	2009	5	55	55	CD
en-wikipedia-org-4107	2009	6	.	.	.
en-wikipedia-org-4107	2010	1	Archived	Archived	NNP
en-wikipedia-org-4107	2010	2	(	(	-LRB-
en-wikipedia-org-4107	2010	3	PDF	PDF	NNP
en-wikipedia-org-4107	2010	4	)	)	-RRB-
en-wikipedia-org-4107	2010	5	from	from	IN
en-wikipedia-org-4107	2010	6	the	the	DT
en-wikipedia-org-4107	2010	7	original	original	NN
en-wikipedia-org-4107	2010	8	on	on	IN
en-wikipedia-org-4107	2010	9	14	14	CD
en-wikipedia-org-4107	2010	10	May	May	NNP
en-wikipedia-org-4107	2010	11	2018	2018	CD
en-wikipedia-org-4107	2010	12	.	.	.
en-wikipedia-org-4107	2011	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	2011	2	31	31	CD
en-wikipedia-org-4107	2011	3	October	October	NNP
en-wikipedia-org-4107	2011	4	2013	2013	CD
en-wikipedia-org-4107	2011	5	.	.	.
en-wikipedia-org-4107	2012	1	A	a	DT
en-wikipedia-org-4107	2012	2	single	single	JJ
en-wikipedia-org-4107	2012	3	dose	dose	NN
en-wikipedia-org-4107	2012	4	of	of	IN
en-wikipedia-org-4107	2012	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2012	6	or	or	CC
en-wikipedia-org-4107	2012	7	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	2012	8	can	can	MD
en-wikipedia-org-4107	2012	9	be	be	VB
en-wikipedia-org-4107	2012	10	detected	detect	VBN
en-wikipedia-org-4107	2012	11	in	in	IN
en-wikipedia-org-4107	2012	12	the	the	DT
en-wikipedia-org-4107	2012	13	urine	urine	NN
en-wikipedia-org-4107	2012	14	for	for	IN
en-wikipedia-org-4107	2012	15	approximately	approximately	RB
en-wikipedia-org-4107	2012	16	24	24	CD
en-wikipedia-org-4107	2012	17	hours	hour	NNS
en-wikipedia-org-4107	2012	18	,	,	,
en-wikipedia-org-4107	2012	19	depending	depend	VBG
en-wikipedia-org-4107	2012	20	upon	upon	IN
en-wikipedia-org-4107	2012	21	urine	urine	NN
en-wikipedia-org-4107	2012	22	pH	ph	NN
en-wikipedia-org-4107	2012	23	and	and	CC
en-wikipedia-org-4107	2012	24	individual	individual	JJ
en-wikipedia-org-4107	2012	25	metabolic	metabolic	JJ
en-wikipedia-org-4107	2012	26	differences	difference	NNS
en-wikipedia-org-4107	2012	27	.	.	.
en-wikipedia-org-4107	2013	1	People	People	NNS
en-wikipedia-org-4107	2013	2	who	who	WP
en-wikipedia-org-4107	2013	3	use	use	VBP
en-wikipedia-org-4107	2013	4	chronically	chronically	RB
en-wikipedia-org-4107	2013	5	and	and	CC
en-wikipedia-org-4107	2013	6	at	at	IN
en-wikipedia-org-4107	2013	7	high	high	JJ
en-wikipedia-org-4107	2013	8	doses	dose	NNS
en-wikipedia-org-4107	2013	9	may	may	MD
en-wikipedia-org-4107	2013	10	continue	continue	VB
en-wikipedia-org-4107	2013	11	to	to	TO
en-wikipedia-org-4107	2013	12	have	have	VB
en-wikipedia-org-4107	2013	13	positive	positive	JJ
en-wikipedia-org-4107	2013	14	urine	urine	NN
en-wikipedia-org-4107	2013	15	specimens	specimen	NNS
en-wikipedia-org-4107	2013	16	for	for	IN
en-wikipedia-org-4107	2013	17	2–4	2–4	CD
en-wikipedia-org-4107	2013	18	days	day	NNS
en-wikipedia-org-4107	2013	19	after	after	IN
en-wikipedia-org-4107	2013	20	last	last	JJ
en-wikipedia-org-4107	2013	21	use	use	NN
en-wikipedia-org-4107	2013	22	(	(	-LRB-
en-wikipedia-org-4107	2013	23	SAMHSA	SAMHSA	NNP
en-wikipedia-org-4107	2013	24	,	,	,
en-wikipedia-org-4107	2013	25	2010b	2010b	CD
en-wikipedia-org-4107	2013	26	)	)	-RRB-
en-wikipedia-org-4107	2013	27	.	.	.
en-wikipedia-org-4107	2014	1	^	^	NNP
en-wikipedia-org-4107	2014	2	a	a	DT
en-wikipedia-org-4107	2014	3	b	b	NNP
en-wikipedia-org-4107	2014	4	c	c	NN
en-wikipedia-org-4107	2014	5	d	d	NN
en-wikipedia-org-4107	2014	6	e	e	NN
en-wikipedia-org-4107	2014	7	Paul	Paul	NNP
en-wikipedia-org-4107	2014	8	BD	BD	NNP
en-wikipedia-org-4107	2014	9	,	,	,
en-wikipedia-org-4107	2014	10	Jemionek	Jemionek	NNP
en-wikipedia-org-4107	2014	11	J	J	NNP
en-wikipedia-org-4107	2014	12	,	,	,
en-wikipedia-org-4107	2014	13	Lesser	Lesser	NNP
en-wikipedia-org-4107	2014	14	D	D	NNP
en-wikipedia-org-4107	2014	15	,	,	,
en-wikipedia-org-4107	2014	16	Jacobs	Jacobs	NNP
en-wikipedia-org-4107	2014	17	A	A	NNP
en-wikipedia-org-4107	2014	18	,	,	,
en-wikipedia-org-4107	2014	19	Searles	Searles	NNP
en-wikipedia-org-4107	2014	20	DA	DA	NNP
en-wikipedia-org-4107	2014	21	(	(	-LRB-
en-wikipedia-org-4107	2014	22	September	September	NNP
en-wikipedia-org-4107	2014	23	2004	2004	CD
en-wikipedia-org-4107	2014	24	)	)	-RRB-
en-wikipedia-org-4107	2014	25	.	.	.
en-wikipedia-org-4107	2015	1	"	"	``
en-wikipedia-org-4107	2015	2	Enantiomeric	enantiomeric	JJ
en-wikipedia-org-4107	2015	3	separation	separation	NN
en-wikipedia-org-4107	2015	4	and	and	CC
en-wikipedia-org-4107	2015	5	quantitation	quantitation	NN
en-wikipedia-org-4107	2015	6	of	of	IN
en-wikipedia-org-4107	2015	7	(	(	-LRB-
en-wikipedia-org-4107	2015	8	±)-amphetamine	±)-amphetamine	NN
en-wikipedia-org-4107	2015	9	,	,	,
en-wikipedia-org-4107	2015	10	(	(	-LRB-
en-wikipedia-org-4107	2015	11	±)-methamphetamine	±)-methamphetamine	RB
en-wikipedia-org-4107	2015	12	,	,	,
en-wikipedia-org-4107	2015	13	(	(	-LRB-
en-wikipedia-org-4107	2015	14	±)-MDA	±)-MDA	NNP
en-wikipedia-org-4107	2015	15	,	,	,
en-wikipedia-org-4107	2015	16	(	(	-LRB-
en-wikipedia-org-4107	2015	17	±)-MDMA	±)-mdma	CC
en-wikipedia-org-4107	2015	18	,	,	,
en-wikipedia-org-4107	2015	19	and	and	CC
en-wikipedia-org-4107	2015	20	(	(	-LRB-
en-wikipedia-org-4107	2015	21	±)-MDEA	±)-mdea	FW
en-wikipedia-org-4107	2015	22	in	in	IN
en-wikipedia-org-4107	2015	23	urine	urine	NN
en-wikipedia-org-4107	2015	24	specimens	specimen	NNS
en-wikipedia-org-4107	2015	25	by	by	IN
en-wikipedia-org-4107	2015	26	GC	GC	NNP
en-wikipedia-org-4107	2015	27	-	-	HYPH
en-wikipedia-org-4107	2015	28	EI	EI	NNP
en-wikipedia-org-4107	2015	29	-	-	HYPH
en-wikipedia-org-4107	2015	30	MS	MS	NNP
en-wikipedia-org-4107	2015	31	after	after	IN
en-wikipedia-org-4107	2015	32	derivatization	derivatization	NN
en-wikipedia-org-4107	2015	33	with	with	IN
en-wikipedia-org-4107	2015	34	(	(	-LRB-
en-wikipedia-org-4107	2015	35	R)-(−)-	R)-(−)-	NNS
en-wikipedia-org-4107	2015	36	or	or	CC
en-wikipedia-org-4107	2015	37	(	(	-LRB-
en-wikipedia-org-4107	2015	38	S)-(+)-α	s)-(+)-α	CD
en-wikipedia-org-4107	2015	39	-	-	HYPH
en-wikipedia-org-4107	2015	40	methoxy	methoxy	JJ
en-wikipedia-org-4107	2015	41	-	-	HYPH
en-wikipedia-org-4107	2015	42	α-(trifluoromethyl)phenylacetyl	α-(trifluoromethyl)phenylacetyl	NN
en-wikipedia-org-4107	2015	43	chloride	chloride	NN
en-wikipedia-org-4107	2015	44	(	(	-LRB-
en-wikipedia-org-4107	2015	45	MTPA	MTPA	NNP
en-wikipedia-org-4107	2015	46	)	)	-RRB-
en-wikipedia-org-4107	2015	47	"	"	''
en-wikipedia-org-4107	2015	48	.	.	.
en-wikipedia-org-4107	2016	1	Journal	Journal	NNP
en-wikipedia-org-4107	2016	2	of	of	IN
en-wikipedia-org-4107	2016	3	Analytical	Analytical	NNP
en-wikipedia-org-4107	2016	4	Toxicology	Toxicology	NNP
en-wikipedia-org-4107	2016	5	.	.	.
en-wikipedia-org-4107	2017	1	28	28	CD
en-wikipedia-org-4107	2017	2	(	(	-LRB-
en-wikipedia-org-4107	2017	3	6	6	CD
en-wikipedia-org-4107	2017	4	)	)	-RRB-
en-wikipedia-org-4107	2017	5	:	:	:
en-wikipedia-org-4107	2017	6	449–455	449–455	CD
en-wikipedia-org-4107	2017	7	.	.	.
en-wikipedia-org-4107	2018	1	doi:10.1093	doi:10.1093	NNP
en-wikipedia-org-4107	2018	2	/	/	SYM
en-wikipedia-org-4107	2018	3	jat/28.6.449	jat/28.6.449	NNP
en-wikipedia-org-4107	2018	4	.	.	.
en-wikipedia-org-4107	2019	1	PMID	PMID	NNP
en-wikipedia-org-4107	2019	2	 	  	_SP
en-wikipedia-org-4107	2019	3	15516295	15516295	CD
en-wikipedia-org-4107	2019	4	.	.	.
en-wikipedia-org-4107	2020	1	^	^	FW
en-wikipedia-org-4107	2020	2	"	"	``
en-wikipedia-org-4107	2020	3	Part	Part	NNP
en-wikipedia-org-4107	2020	4	341	341	CD
en-wikipedia-org-4107	2020	5	–	–	:
en-wikipedia-org-4107	2020	6	cold	cold	JJ
en-wikipedia-org-4107	2020	7	,	,	,
en-wikipedia-org-4107	2020	8	cough	cough	NN
en-wikipedia-org-4107	2020	9	,	,	,
en-wikipedia-org-4107	2020	10	allergy	allergy	NN
en-wikipedia-org-4107	2020	11	,	,	,
en-wikipedia-org-4107	2020	12	bronchodilator	bronchodilator	NN
en-wikipedia-org-4107	2020	13	,	,	,
en-wikipedia-org-4107	2020	14	and	and	CC
en-wikipedia-org-4107	2020	15	antiasthmatic	antiasthmatic	JJ
en-wikipedia-org-4107	2020	16	drug	drug	NN
en-wikipedia-org-4107	2020	17	products	product	NNS
en-wikipedia-org-4107	2020	18	for	for	IN
en-wikipedia-org-4107	2020	19	over	over	IN
en-wikipedia-org-4107	2020	20	-	-	HYPH
en-wikipedia-org-4107	2020	21	the	the	DT
en-wikipedia-org-4107	2020	22	-	-	HYPH
en-wikipedia-org-4107	2020	23	counter	counter	NN
en-wikipedia-org-4107	2020	24	human	human	JJ
en-wikipedia-org-4107	2020	25	use	use	NN
en-wikipedia-org-4107	2020	26	"	"	''
en-wikipedia-org-4107	2020	27	.	.	.
en-wikipedia-org-4107	2021	1	Code	Code	NNP
en-wikipedia-org-4107	2021	2	of	of	IN
en-wikipedia-org-4107	2021	3	Federal	Federal	NNP
en-wikipedia-org-4107	2021	4	Regulations	Regulations	NNPS
en-wikipedia-org-4107	2021	5	Title	Title	NNP
en-wikipedia-org-4107	2021	6	21	21	CD
en-wikipedia-org-4107	2021	7	:	:	:
en-wikipedia-org-4107	2021	8	Subchapter	subchapter	NN
en-wikipedia-org-4107	2021	9	D	d	NN
en-wikipedia-org-4107	2021	10	–	–	:
en-wikipedia-org-4107	2021	11	Drugs	drug	NNS
en-wikipedia-org-4107	2021	12	for	for	IN
en-wikipedia-org-4107	2021	13	human	human	JJ
en-wikipedia-org-4107	2021	14	use	use	NN
en-wikipedia-org-4107	2021	15	.	.	.
en-wikipedia-org-4107	2022	1	United	United	NNP
en-wikipedia-org-4107	2022	2	States	States	NNP
en-wikipedia-org-4107	2022	3	Food	Food	NNP
en-wikipedia-org-4107	2022	4	and	and	CC
en-wikipedia-org-4107	2022	5	Drug	Drug	NNP
en-wikipedia-org-4107	2022	6	Administration	Administration	NNP
en-wikipedia-org-4107	2022	7	.	.	.
en-wikipedia-org-4107	2023	1	1	1	CD
en-wikipedia-org-4107	2023	2	April	April	NNP
en-wikipedia-org-4107	2023	3	2019	2019	CD
en-wikipedia-org-4107	2023	4	.	.	.
en-wikipedia-org-4107	2024	1	Archived	archived	JJ
en-wikipedia-org-4107	2024	2	from	from	IN
en-wikipedia-org-4107	2024	3	the	the	DT
en-wikipedia-org-4107	2024	4	original	original	NN
en-wikipedia-org-4107	2024	5	on	on	IN
en-wikipedia-org-4107	2024	6	25	25	CD
en-wikipedia-org-4107	2024	7	December	December	NNP
en-wikipedia-org-4107	2024	8	2019	2019	CD
en-wikipedia-org-4107	2024	9	.	.	.
en-wikipedia-org-4107	2025	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2025	2	24	24	CD
en-wikipedia-org-4107	2025	3	December	December	NNP
en-wikipedia-org-4107	2025	4	2019	2019	CD
en-wikipedia-org-4107	2025	5	.	.	.
en-wikipedia-org-4107	2026	1	Topical	topical	JJ
en-wikipedia-org-4107	2026	2	nasal	nasal	NN
en-wikipedia-org-4107	2026	3	decongestants	decongestant	NNS
en-wikipedia-org-4107	2026	4	--(i	--(i	:
en-wikipedia-org-4107	2026	5	)	)	-RRB-
en-wikipedia-org-4107	2026	6	For	for	IN
en-wikipedia-org-4107	2026	7	products	product	NNS
en-wikipedia-org-4107	2026	8	containing	contain	VBG
en-wikipedia-org-4107	2026	9	levmetamfetamine	levmetamfetamine	NN
en-wikipedia-org-4107	2026	10	identified	identify	VBN
en-wikipedia-org-4107	2026	11	in	in	IN
en-wikipedia-org-4107	2026	12	341.20(b)(1	341.20(b)(1	NNP
en-wikipedia-org-4107	2026	13	)	)	-RRB-
en-wikipedia-org-4107	2026	14	when	when	WRB
en-wikipedia-org-4107	2026	15	used	use	VBN
en-wikipedia-org-4107	2026	16	in	in	IN
en-wikipedia-org-4107	2026	17	an	an	DT
en-wikipedia-org-4107	2026	18	inhalant	inhalant	JJ
en-wikipedia-org-4107	2026	19	dosage	dosage	NN
en-wikipedia-org-4107	2026	20	form	form	NN
en-wikipedia-org-4107	2026	21	.	.	.
en-wikipedia-org-4107	2027	1	The	the	DT
en-wikipedia-org-4107	2027	2	product	product	NN
en-wikipedia-org-4107	2027	3	delivers	deliver	VBZ
en-wikipedia-org-4107	2027	4	in	in	IN
en-wikipedia-org-4107	2027	5	each	each	DT
en-wikipedia-org-4107	2027	6	800	800	CD
en-wikipedia-org-4107	2027	7	milliliters	milliliter	NNS
en-wikipedia-org-4107	2027	8	of	of	IN
en-wikipedia-org-4107	2027	9	air	air	NN
en-wikipedia-org-4107	2027	10	0.04	0.04	CD
en-wikipedia-org-4107	2027	11	to	to	IN
en-wikipedia-org-4107	2027	12	0.150	0.150	CD
en-wikipedia-org-4107	2027	13	milligrams	milligram	NNS
en-wikipedia-org-4107	2027	14	of	of	IN
en-wikipedia-org-4107	2027	15	levmetamfetamine	levmetamfetamine	NN
en-wikipedia-org-4107	2027	16	.	.	.
en-wikipedia-org-4107	2028	1	^	^	FW
en-wikipedia-org-4107	2028	2	"	"	``
en-wikipedia-org-4107	2028	3	Identification	identification	NN
en-wikipedia-org-4107	2028	4	"	"	''
en-wikipedia-org-4107	2028	5	.	.	.
en-wikipedia-org-4107	2029	1	Levomethamphetamine	Levomethamphetamine	NNP
en-wikipedia-org-4107	2029	2	.	.	.
en-wikipedia-org-4107	2030	1	Pubchem	Pubchem	NNP
en-wikipedia-org-4107	2030	2	Compound	Compound	NNP
en-wikipedia-org-4107	2030	3	Database	Database	NNP
en-wikipedia-org-4107	2030	4	.	.	.
en-wikipedia-org-4107	2031	1	United	United	NNP
en-wikipedia-org-4107	2031	2	States	States	NNP
en-wikipedia-org-4107	2031	3	National	National	NNP
en-wikipedia-org-4107	2031	4	Library	Library	NNP
en-wikipedia-org-4107	2031	5	of	of	IN
en-wikipedia-org-4107	2031	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	2031	7	 	  	_SP
en-wikipedia-org-4107	2031	8	–	–	:
en-wikipedia-org-4107	2031	9	National	National	NNP
en-wikipedia-org-4107	2031	10	Center	Center	NNP
en-wikipedia-org-4107	2031	11	for	for	IN
en-wikipedia-org-4107	2031	12	Biotechnology	Biotechnology	NNP
en-wikipedia-org-4107	2031	13	Information	Information	NNP
en-wikipedia-org-4107	2031	14	.	.	.
en-wikipedia-org-4107	2032	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2032	2	2	2	CD
en-wikipedia-org-4107	2032	3	January	January	NNP
en-wikipedia-org-4107	2032	4	2014	2014	CD
en-wikipedia-org-4107	2032	5	.	.	.
en-wikipedia-org-4107	2033	1	^	^	NNP
en-wikipedia-org-4107	2033	2	a	a	DT
en-wikipedia-org-4107	2033	3	b	b	NNP
en-wikipedia-org-4107	2033	4	Verstraete	Verstraete	NNP
en-wikipedia-org-4107	2033	5	AG	AG	NNP
en-wikipedia-org-4107	2033	6	,	,	,
en-wikipedia-org-4107	2033	7	Heyden	Heyden	NNP
en-wikipedia-org-4107	2033	8	FV	FV	NNP
en-wikipedia-org-4107	2033	9	(	(	-LRB-
en-wikipedia-org-4107	2033	10	August	August	NNP
en-wikipedia-org-4107	2033	11	2005	2005	CD
en-wikipedia-org-4107	2033	12	)	)	-RRB-
en-wikipedia-org-4107	2033	13	.	.	.
en-wikipedia-org-4107	2034	1	"	"	``
en-wikipedia-org-4107	2034	2	Comparison	comparison	NN
en-wikipedia-org-4107	2034	3	of	of	IN
en-wikipedia-org-4107	2034	4	the	the	DT
en-wikipedia-org-4107	2034	5	sensitivity	sensitivity	NN
en-wikipedia-org-4107	2034	6	and	and	CC
en-wikipedia-org-4107	2034	7	specificity	specificity	NN
en-wikipedia-org-4107	2034	8	of	of	IN
en-wikipedia-org-4107	2034	9	six	six	CD
en-wikipedia-org-4107	2034	10	immunoassays	immunoassay	NNS
en-wikipedia-org-4107	2034	11	for	for	IN
en-wikipedia-org-4107	2034	12	the	the	DT
en-wikipedia-org-4107	2034	13	detection	detection	NN
en-wikipedia-org-4107	2034	14	of	of	IN
en-wikipedia-org-4107	2034	15	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	2034	16	in	in	IN
en-wikipedia-org-4107	2034	17	urine	urine	NN
en-wikipedia-org-4107	2034	18	"	"	''
en-wikipedia-org-4107	2034	19	.	.	.
en-wikipedia-org-4107	2035	1	Journal	Journal	NNP
en-wikipedia-org-4107	2035	2	of	of	IN
en-wikipedia-org-4107	2035	3	Analytical	Analytical	NNP
en-wikipedia-org-4107	2035	4	Toxicology	Toxicology	NNP
en-wikipedia-org-4107	2035	5	.	.	.
en-wikipedia-org-4107	2036	1	29	29	CD
en-wikipedia-org-4107	2036	2	(	(	-LRB-
en-wikipedia-org-4107	2036	3	5	5	CD
en-wikipedia-org-4107	2036	4	)	)	-RRB-
en-wikipedia-org-4107	2036	5	:	:	:
en-wikipedia-org-4107	2036	6	359–364	359–364	CD
en-wikipedia-org-4107	2036	7	.	.	.
en-wikipedia-org-4107	2037	1	doi:10.1093	doi:10.1093	NNP
en-wikipedia-org-4107	2037	2	/	/	SYM
en-wikipedia-org-4107	2037	3	jat/29.5.359	jat/29.5.359	NNP
en-wikipedia-org-4107	2037	4	.	.	.
en-wikipedia-org-4107	2038	1	PMID	PMID	NNP
en-wikipedia-org-4107	2038	2	 	  	_SP
en-wikipedia-org-4107	2038	3	16105261	16105261	CD
en-wikipedia-org-4107	2038	4	.	.	.
en-wikipedia-org-4107	2039	1	^	^	NNP
en-wikipedia-org-4107	2039	2	Baselt	Baselt	NNP
en-wikipedia-org-4107	2039	3	RC	RC	NNP
en-wikipedia-org-4107	2039	4	(	(	-LRB-
en-wikipedia-org-4107	2039	5	2011	2011	CD
en-wikipedia-org-4107	2039	6	)	)	-RRB-
en-wikipedia-org-4107	2039	7	.	.	.
en-wikipedia-org-4107	2040	1	Disposition	disposition	NN
en-wikipedia-org-4107	2040	2	of	of	IN
en-wikipedia-org-4107	2040	3	Toxic	Toxic	NNP
en-wikipedia-org-4107	2040	4	Drugs	Drugs	NNPS
en-wikipedia-org-4107	2040	5	and	and	CC
en-wikipedia-org-4107	2040	6	Chemicals	Chemicals	NNPS
en-wikipedia-org-4107	2040	7	in	in	IN
en-wikipedia-org-4107	2040	8	Man	Man	NNP
en-wikipedia-org-4107	2040	9	(	(	-LRB-
en-wikipedia-org-4107	2040	10	9th	9th	NNP
en-wikipedia-org-4107	2040	11	ed	ed	NNP
en-wikipedia-org-4107	2040	12	.	.	.
en-wikipedia-org-4107	2040	13	)	)	-RRB-
en-wikipedia-org-4107	2040	14	.	.	.
en-wikipedia-org-4107	2041	1	Seal	Seal	NNP
en-wikipedia-org-4107	2041	2	Beach	Beach	NNP
en-wikipedia-org-4107	2041	3	,	,	,
en-wikipedia-org-4107	2041	4	USA	USA	NNP
en-wikipedia-org-4107	2041	5	:	:	:
en-wikipedia-org-4107	2041	6	Biomedical	Biomedical	NNP
en-wikipedia-org-4107	2041	7	Publications	Publications	NNPS
en-wikipedia-org-4107	2041	8	.	.	.
en-wikipedia-org-4107	2042	1	pp	pp	NNP
en-wikipedia-org-4107	2042	2	.	.	.
en-wikipedia-org-4107	2043	1	85–88	85–88	CD
en-wikipedia-org-4107	2043	2	.	.	.
en-wikipedia-org-4107	2044	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	2044	2	 	  	_SP
en-wikipedia-org-4107	2044	3	9780962652387	9780962652387	CD
en-wikipedia-org-4107	2044	4	.	.	.
en-wikipedia-org-4107	2045	1	^	^	NNP
en-wikipedia-org-4107	2045	2	a	a	DT
en-wikipedia-org-4107	2045	3	b	b	NN
en-wikipedia-org-4107	2045	4	Musshoff	Musshoff	NNP
en-wikipedia-org-4107	2045	5	F	F	NNP
en-wikipedia-org-4107	2045	6	(	(	-LRB-
en-wikipedia-org-4107	2045	7	February	February	NNP
en-wikipedia-org-4107	2045	8	2000	2000	CD
en-wikipedia-org-4107	2045	9	)	)	-RRB-
en-wikipedia-org-4107	2045	10	.	.	.
en-wikipedia-org-4107	2046	1	"	"	``
en-wikipedia-org-4107	2046	2	Illegal	illegal	JJ
en-wikipedia-org-4107	2046	3	or	or	CC
en-wikipedia-org-4107	2046	4	legitimate	legitimate	JJ
en-wikipedia-org-4107	2046	5	use	use	NN
en-wikipedia-org-4107	2046	6	?	?	.
en-wikipedia-org-4107	2047	1	Precursor	precursor	NN
en-wikipedia-org-4107	2047	2	compounds	compound	VBZ
en-wikipedia-org-4107	2047	3	to	to	TO
en-wikipedia-org-4107	2047	4	amphetamine	amphetamine	VB
en-wikipedia-org-4107	2047	5	and	and	CC
en-wikipedia-org-4107	2047	6	methamphetamine	methamphetamine	VB
en-wikipedia-org-4107	2047	7	"	"	''
en-wikipedia-org-4107	2047	8	.	.	.
en-wikipedia-org-4107	2048	1	Drug	Drug	NNP
en-wikipedia-org-4107	2048	2	Metabolism	Metabolism	NNP
en-wikipedia-org-4107	2048	3	Reviews	Reviews	NNP
en-wikipedia-org-4107	2048	4	.	.	.
en-wikipedia-org-4107	2049	1	32	32	CD
en-wikipedia-org-4107	2049	2	(	(	-LRB-
en-wikipedia-org-4107	2049	3	1	1	CD
en-wikipedia-org-4107	2049	4	)	)	-RRB-
en-wikipedia-org-4107	2049	5	:	:	:
en-wikipedia-org-4107	2049	6	15–44	15–44	CD
en-wikipedia-org-4107	2049	7	.	.	.
en-wikipedia-org-4107	2050	1	doi:10.1081	doi:10.1081	NNP
en-wikipedia-org-4107	2050	2	/	/	SYM
en-wikipedia-org-4107	2050	3	DMR-100100562	DMR-100100562	NNP
en-wikipedia-org-4107	2050	4	.	.	.
en-wikipedia-org-4107	2051	1	PMID	PMID	NNP
en-wikipedia-org-4107	2051	2	 	  	_SP
en-wikipedia-org-4107	2051	3	10711406	10711406	CD
en-wikipedia-org-4107	2051	4	.	.	.
en-wikipedia-org-4107	2052	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	2052	2	 	  	_SP
en-wikipedia-org-4107	2052	3	20012024	20012024	CD
en-wikipedia-org-4107	2052	4	.	.	.
en-wikipedia-org-4107	2053	1	^	^	NNP
en-wikipedia-org-4107	2053	2	a	a	DT
en-wikipedia-org-4107	2053	3	b	b	NNP
en-wikipedia-org-4107	2053	4	Cody	Cody	NNP
en-wikipedia-org-4107	2053	5	JT	JT	NNP
en-wikipedia-org-4107	2053	6	(	(	-LRB-
en-wikipedia-org-4107	2053	7	May	May	NNP
en-wikipedia-org-4107	2053	8	2002	2002	CD
en-wikipedia-org-4107	2053	9	)	)	-RRB-
en-wikipedia-org-4107	2053	10	.	.	.
en-wikipedia-org-4107	2054	1	"	"	``
en-wikipedia-org-4107	2054	2	Precursor	precursor	NN
en-wikipedia-org-4107	2054	3	medications	medication	NNS
en-wikipedia-org-4107	2054	4	as	as	IN
en-wikipedia-org-4107	2054	5	a	a	DT
en-wikipedia-org-4107	2054	6	source	source	NN
en-wikipedia-org-4107	2054	7	of	of	IN
en-wikipedia-org-4107	2054	8	methamphetamine	methamphetamine	NN
en-wikipedia-org-4107	2054	9	and/or	and/or	CC
en-wikipedia-org-4107	2054	10	amphetamine	amphetamine	VB
en-wikipedia-org-4107	2054	11	positive	positive	JJ
en-wikipedia-org-4107	2054	12	drug	drug	NN
en-wikipedia-org-4107	2054	13	testing	testing	NN
en-wikipedia-org-4107	2054	14	results	result	NNS
en-wikipedia-org-4107	2054	15	"	"	''
en-wikipedia-org-4107	2054	16	.	.	.
en-wikipedia-org-4107	2055	1	Journal	Journal	NNP
en-wikipedia-org-4107	2055	2	of	of	IN
en-wikipedia-org-4107	2055	3	Occupational	Occupational	NNP
en-wikipedia-org-4107	2055	4	and	and	CC
en-wikipedia-org-4107	2055	5	Environmental	Environmental	NNP
en-wikipedia-org-4107	2055	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	2055	7	.	.	.
en-wikipedia-org-4107	2056	1	44	44	CD
en-wikipedia-org-4107	2056	2	(	(	-LRB-
en-wikipedia-org-4107	2056	3	5	5	CD
en-wikipedia-org-4107	2056	4	)	)	-RRB-
en-wikipedia-org-4107	2056	5	:	:	:
en-wikipedia-org-4107	2056	6	435–450	435–450	CD
en-wikipedia-org-4107	2056	7	.	.	.
en-wikipedia-org-4107	2057	1	doi:10.1097/00043764	doi:10.1097/00043764	NNP
en-wikipedia-org-4107	2057	2	-	-	HYPH
en-wikipedia-org-4107	2057	3	200205000	200205000	CD
en-wikipedia-org-4107	2057	4	-	-	SYM
en-wikipedia-org-4107	2057	5	00012	00012	CD
en-wikipedia-org-4107	2057	6	.	.	.
en-wikipedia-org-4107	2058	1	PMID	PMID	NNP
en-wikipedia-org-4107	2058	2	 	  	_SP
en-wikipedia-org-4107	2058	3	12024689	12024689	CD
en-wikipedia-org-4107	2058	4	.	.	.
en-wikipedia-org-4107	2059	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	2059	2	 	  	_SP
en-wikipedia-org-4107	2059	3	44614179	44614179	CD
en-wikipedia-org-4107	2059	4	.	.	.
en-wikipedia-org-4107	2060	1	^	^	FW
en-wikipedia-org-4107	2060	2	"	"	``
en-wikipedia-org-4107	2060	3	Annual	annual	JJ
en-wikipedia-org-4107	2060	4	prevalence	prevalence	NN
en-wikipedia-org-4107	2060	5	of	of	IN
en-wikipedia-org-4107	2060	6	use	use	NN
en-wikipedia-org-4107	2060	7	of	of	IN
en-wikipedia-org-4107	2060	8	drugs	drug	NNS
en-wikipedia-org-4107	2060	9	,	,	,
en-wikipedia-org-4107	2060	10	by	by	IN
en-wikipedia-org-4107	2060	11	region	region	NN
en-wikipedia-org-4107	2060	12	and	and	CC
en-wikipedia-org-4107	2060	13	globally	globally	RB
en-wikipedia-org-4107	2060	14	,	,	,
en-wikipedia-org-4107	2060	15	2016	2016	CD
en-wikipedia-org-4107	2060	16	"	"	''
en-wikipedia-org-4107	2060	17	.	.	.
en-wikipedia-org-4107	2061	1	World	World	NNP
en-wikipedia-org-4107	2061	2	Drug	Drug	NNP
en-wikipedia-org-4107	2061	3	Report	Report	NNP
en-wikipedia-org-4107	2061	4	2018	2018	CD
en-wikipedia-org-4107	2061	5	.	.	.
en-wikipedia-org-4107	2062	1	United	United	NNP
en-wikipedia-org-4107	2062	2	Nations	Nations	NNP
en-wikipedia-org-4107	2062	3	Office	Office	NNP
en-wikipedia-org-4107	2062	4	on	on	IN
en-wikipedia-org-4107	2062	5	Drugs	Drugs	NNPS
en-wikipedia-org-4107	2062	6	and	and	CC
en-wikipedia-org-4107	2062	7	Crime	Crime	NNP
en-wikipedia-org-4107	2062	8	.	.	.
en-wikipedia-org-4107	2063	1	2018	2018	CD
en-wikipedia-org-4107	2063	2	.	.	.
en-wikipedia-org-4107	2064	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	2064	2	7	7	CD
en-wikipedia-org-4107	2064	3	July	July	NNP
en-wikipedia-org-4107	2064	4	2018	2018	CD
en-wikipedia-org-4107	2064	5	.	.	.
en-wikipedia-org-4107	2065	1	^	^	NNP
en-wikipedia-org-4107	2065	2	Rassool	Rassool	NNP
en-wikipedia-org-4107	2065	3	GH	GH	NNP
en-wikipedia-org-4107	2065	4	(	(	-LRB-
en-wikipedia-org-4107	2065	5	2009	2009	CD
en-wikipedia-org-4107	2065	6	)	)	-RRB-
en-wikipedia-org-4107	2065	7	.	.	.
en-wikipedia-org-4107	2066	1	Alcohol	Alcohol	NNP
en-wikipedia-org-4107	2066	2	and	and	CC
en-wikipedia-org-4107	2066	3	Drug	Drug	NNP
en-wikipedia-org-4107	2066	4	Misuse	Misuse	NNP
en-wikipedia-org-4107	2066	5	:	:	:
en-wikipedia-org-4107	2066	6	A	a	DT
en-wikipedia-org-4107	2066	7	Handbook	Handbook	NNP
en-wikipedia-org-4107	2066	8	for	for	IN
en-wikipedia-org-4107	2066	9	Students	Students	NNPS
en-wikipedia-org-4107	2066	10	and	and	CC
en-wikipedia-org-4107	2066	11	Health	Health	NNP
en-wikipedia-org-4107	2066	12	Professionals	Professionals	NNPS
en-wikipedia-org-4107	2066	13	.	.	.
en-wikipedia-org-4107	2067	1	London	London	NNP
en-wikipedia-org-4107	2067	2	,	,	,
en-wikipedia-org-4107	2067	3	England	England	NNP
en-wikipedia-org-4107	2067	4	:	:	:
en-wikipedia-org-4107	2067	5	Routledge	Routledge	NNP
en-wikipedia-org-4107	2067	6	.	.	.
en-wikipedia-org-4107	2068	1	p.	p.	NN
en-wikipedia-org-4107	2068	2	 	  	_SP
en-wikipedia-org-4107	2068	3	113	113	CD
en-wikipedia-org-4107	2068	4	.	.	.
en-wikipedia-org-4107	2069	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	2069	2	 	  	_SP
en-wikipedia-org-4107	2069	3	9780203871171	9780203871171	CD
en-wikipedia-org-4107	2069	4	.	.	.
en-wikipedia-org-4107	2070	1	^	^	NNP
en-wikipedia-org-4107	2070	2	a	a	DT
en-wikipedia-org-4107	2070	3	b	b	NNP
en-wikipedia-org-4107	2070	4	Sulzer	Sulzer	NNP
en-wikipedia-org-4107	2070	5	D	D	NNP
en-wikipedia-org-4107	2070	6	,	,	,
en-wikipedia-org-4107	2070	7	Sonders	Sonders	NNP
en-wikipedia-org-4107	2070	8	MS	MS	NNP
en-wikipedia-org-4107	2070	9	,	,	,
en-wikipedia-org-4107	2070	10	Poulsen	Poulsen	NNP
en-wikipedia-org-4107	2070	11	NW	NW	NNP
en-wikipedia-org-4107	2070	12	,	,	,
en-wikipedia-org-4107	2070	13	Galli	Galli	NNP
en-wikipedia-org-4107	2070	14	A	A	NNP
en-wikipedia-org-4107	2070	15	(	(	-LRB-
en-wikipedia-org-4107	2070	16	April	April	NNP
en-wikipedia-org-4107	2070	17	2005	2005	CD
en-wikipedia-org-4107	2070	18	)	)	-RRB-
en-wikipedia-org-4107	2070	19	.	.	.
en-wikipedia-org-4107	2071	1	"	"	``
en-wikipedia-org-4107	2071	2	Mechanisms	Mechanisms	NNPS
en-wikipedia-org-4107	2071	3	of	of	IN
en-wikipedia-org-4107	2071	4	neurotransmitter	neurotransmitter	NN
en-wikipedia-org-4107	2071	5	release	release	NN
en-wikipedia-org-4107	2071	6	by	by	IN
en-wikipedia-org-4107	2071	7	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	2071	8	:	:	:
en-wikipedia-org-4107	2071	9	a	a	DT
en-wikipedia-org-4107	2071	10	review	review	NN
en-wikipedia-org-4107	2071	11	"	"	''
en-wikipedia-org-4107	2071	12	.	.	.
en-wikipedia-org-4107	2072	1	Progress	progress	NN
en-wikipedia-org-4107	2072	2	in	in	IN
en-wikipedia-org-4107	2072	3	Neurobiology	Neurobiology	NNP
en-wikipedia-org-4107	2072	4	.	.	.
en-wikipedia-org-4107	2073	1	75	75	CD
en-wikipedia-org-4107	2073	2	(	(	-LRB-
en-wikipedia-org-4107	2073	3	6	6	CD
en-wikipedia-org-4107	2073	4	)	)	-RRB-
en-wikipedia-org-4107	2073	5	:	:	:
en-wikipedia-org-4107	2073	6	406–433	406–433	CD
en-wikipedia-org-4107	2073	7	.	.	.
en-wikipedia-org-4107	2074	1	doi:10.1016	doi:10.1016	NNP
en-wikipedia-org-4107	2074	2	/	/	SYM
en-wikipedia-org-4107	2074	3	j.pneurobio.2005.04.003	j.pneurobio.2005.04.003	NN
en-wikipedia-org-4107	2074	4	.	.	.
en-wikipedia-org-4107	2075	1	PMID	PMID	NNP
en-wikipedia-org-4107	2075	2	 	  	_SP
en-wikipedia-org-4107	2075	3	15955613	15955613	CD
en-wikipedia-org-4107	2075	4	.	.	.
en-wikipedia-org-4107	2076	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	2076	2	 	  	_SP
en-wikipedia-org-4107	2076	3	2359509	2359509	CD
en-wikipedia-org-4107	2076	4	.	.	.
en-wikipedia-org-4107	2077	1	^	^	NNP
en-wikipedia-org-4107	2077	2	Rasmussen	Rasmussen	NNP
en-wikipedia-org-4107	2077	3	N	N	NNP
en-wikipedia-org-4107	2077	4	(	(	-LRB-
en-wikipedia-org-4107	2077	5	August	August	NNP
en-wikipedia-org-4107	2077	6	2011	2011	CD
en-wikipedia-org-4107	2077	7	)	)	-RRB-
en-wikipedia-org-4107	2077	8	.	.	.
en-wikipedia-org-4107	2078	1	"	"	``
en-wikipedia-org-4107	2078	2	Medical	medical	JJ
en-wikipedia-org-4107	2078	3	science	science	NN
en-wikipedia-org-4107	2078	4	and	and	CC
en-wikipedia-org-4107	2078	5	the	the	DT
en-wikipedia-org-4107	2078	6	military	military	NN
en-wikipedia-org-4107	2078	7	:	:	:
en-wikipedia-org-4107	2078	8	the	the	DT
en-wikipedia-org-4107	2078	9	Allies	Allies	NNPS
en-wikipedia-org-4107	2078	10	'	'	POS
en-wikipedia-org-4107	2078	11	use	use	NN
en-wikipedia-org-4107	2078	12	of	of	IN
en-wikipedia-org-4107	2078	13	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2078	14	during	during	IN
en-wikipedia-org-4107	2078	15	World	World	NNP
en-wikipedia-org-4107	2078	16	War	War	NNP
en-wikipedia-org-4107	2078	17	II	II	NNP
en-wikipedia-org-4107	2078	18	"	"	''
en-wikipedia-org-4107	2078	19	.	.	.
en-wikipedia-org-4107	2079	1	Journal	Journal	NNP
en-wikipedia-org-4107	2079	2	of	of	IN
en-wikipedia-org-4107	2079	3	Interdisciplinary	Interdisciplinary	NNP
en-wikipedia-org-4107	2079	4	History	History	NNP
en-wikipedia-org-4107	2079	5	.	.	.
en-wikipedia-org-4107	2080	1	42	42	CD
en-wikipedia-org-4107	2080	2	(	(	-LRB-
en-wikipedia-org-4107	2080	3	2	2	CD
en-wikipedia-org-4107	2080	4	)	)	-RRB-
en-wikipedia-org-4107	2080	5	:	:	:
en-wikipedia-org-4107	2080	6	205–233	205–233	CD
en-wikipedia-org-4107	2080	7	.	.	.
en-wikipedia-org-4107	2081	1	doi:10.1162	doi:10.1162	VB
en-wikipedia-org-4107	2081	2	/	/	SYM
en-wikipedia-org-4107	2081	3	JINH_a_00212	JINH_a_00212	NNP
en-wikipedia-org-4107	2081	4	.	.	.
en-wikipedia-org-4107	2082	1	PMID	PMID	NNP
en-wikipedia-org-4107	2082	2	 	  	_SP
en-wikipedia-org-4107	2082	3	22073434	22073434	CD
en-wikipedia-org-4107	2082	4	.	.	.
en-wikipedia-org-4107	2083	1	S2CID	S2CID	NNS
en-wikipedia-org-4107	2083	2	 	  	_SP
en-wikipedia-org-4107	2083	3	34332132	34332132	CD
en-wikipedia-org-4107	2083	4	.	.	.
en-wikipedia-org-4107	2084	1	^	^	NFP
en-wikipedia-org-4107	2084	2	Defalque	Defalque	NNP
en-wikipedia-org-4107	2084	3	RJ	RJ	NNP
en-wikipedia-org-4107	2084	4	,	,	,
en-wikipedia-org-4107	2084	5	Wright	Wright	NNP
en-wikipedia-org-4107	2084	6	AJ	AJ	NNP
en-wikipedia-org-4107	2084	7	(	(	-LRB-
en-wikipedia-org-4107	2084	8	April	April	NNP
en-wikipedia-org-4107	2084	9	2011	2011	CD
en-wikipedia-org-4107	2084	10	)	)	-RRB-
en-wikipedia-org-4107	2084	11	.	.	.
en-wikipedia-org-4107	2085	1	"	"	``
en-wikipedia-org-4107	2085	2	Methamphetamine	Methamphetamine	NNP
en-wikipedia-org-4107	2085	3	for	for	IN
en-wikipedia-org-4107	2085	4	Hitler	Hitler	NNP
en-wikipedia-org-4107	2085	5	's	's	POS
en-wikipedia-org-4107	2085	6	Germany	Germany	NNP
en-wikipedia-org-4107	2085	7	:	:	:
en-wikipedia-org-4107	2085	8	1937	1937	CD
en-wikipedia-org-4107	2085	9	to	to	IN
en-wikipedia-org-4107	2085	10	1945	1945	CD
en-wikipedia-org-4107	2085	11	"	"	''
en-wikipedia-org-4107	2085	12	.	.	.
en-wikipedia-org-4107	2086	1	Bulletin	bulletin	NN
en-wikipedia-org-4107	2086	2	of	of	IN
en-wikipedia-org-4107	2086	3	Anesthesia	Anesthesia	NNP
en-wikipedia-org-4107	2086	4	History	History	NNP
en-wikipedia-org-4107	2086	5	.	.	.
en-wikipedia-org-4107	2087	1	29	29	CD
en-wikipedia-org-4107	2087	2	(	(	-LRB-
en-wikipedia-org-4107	2087	3	2	2	CD
en-wikipedia-org-4107	2087	4	)	)	-RRB-
en-wikipedia-org-4107	2087	5	:	:	:
en-wikipedia-org-4107	2087	6	21–24	21–24	CD
en-wikipedia-org-4107	2087	7	,	,	,
en-wikipedia-org-4107	2087	8	32	32	CD
en-wikipedia-org-4107	2087	9	.	.	.
en-wikipedia-org-4107	2087	10	doi:10.1016	doi:10.1016	JJ
en-wikipedia-org-4107	2087	11	/	/	SYM
en-wikipedia-org-4107	2087	12	s1522	s1522	NNP
en-wikipedia-org-4107	2087	13	-	-	HYPH
en-wikipedia-org-4107	2087	14	8649(11)50016	8649(11)50016	NNP
en-wikipedia-org-4107	2087	15	-	-	HYPH
en-wikipedia-org-4107	2087	16	2	2	NNP
en-wikipedia-org-4107	2087	17	.	.	.
en-wikipedia-org-4107	2088	1	PMID	PMID	NNP
en-wikipedia-org-4107	2088	2	 	  	_SP
en-wikipedia-org-4107	2088	3	22849208	22849208	CD
en-wikipedia-org-4107	2088	4	.	.	.
en-wikipedia-org-4107	2089	1	^	^	FW
en-wikipedia-org-4107	2089	2	"	"	``
en-wikipedia-org-4107	2089	3	Controlled	Controlled	NNP
en-wikipedia-org-4107	2089	4	Substances	Substances	NNP
en-wikipedia-org-4107	2089	5	Act	Act	NNP
en-wikipedia-org-4107	2089	6	"	"	''
en-wikipedia-org-4107	2089	7	.	.	.
en-wikipedia-org-4107	2090	1	United	United	NNP
en-wikipedia-org-4107	2090	2	States	States	NNP
en-wikipedia-org-4107	2090	3	Food	Food	NNP
en-wikipedia-org-4107	2090	4	and	and	CC
en-wikipedia-org-4107	2090	5	Drug	Drug	NNP
en-wikipedia-org-4107	2090	6	Administration	Administration	NNP
en-wikipedia-org-4107	2090	7	.	.	.
en-wikipedia-org-4107	2091	1	11	11	CD
en-wikipedia-org-4107	2091	2	June	June	NNP
en-wikipedia-org-4107	2091	3	2009	2009	CD
en-wikipedia-org-4107	2091	4	.	.	.
en-wikipedia-org-4107	2092	1	Archived	archived	JJ
en-wikipedia-org-4107	2092	2	from	from	IN
en-wikipedia-org-4107	2092	3	the	the	DT
en-wikipedia-org-4107	2092	4	original	original	NN
en-wikipedia-org-4107	2092	5	on	on	IN
en-wikipedia-org-4107	2092	6	2	2	CD
en-wikipedia-org-4107	2092	7	March	March	NNP
en-wikipedia-org-4107	2092	8	2017	2017	CD
en-wikipedia-org-4107	2092	9	.	.	.
en-wikipedia-org-4107	2093	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	2093	2	4	4	CD
en-wikipedia-org-4107	2093	3	November	November	NNP
en-wikipedia-org-4107	2093	4	2013	2013	CD
en-wikipedia-org-4107	2093	5	.	.	.
en-wikipedia-org-4107	2094	1	^	^	FW
en-wikipedia-org-4107	2094	2	"	"	``
en-wikipedia-org-4107	2094	3	Controlled	controlled	JJ
en-wikipedia-org-4107	2094	4	Substance	Substance	NNP
en-wikipedia-org-4107	2094	5	Schedules	Schedules	NNPS
en-wikipedia-org-4107	2094	6	"	"	''
en-wikipedia-org-4107	2094	7	.	.	.
en-wikipedia-org-4107	2095	1	DEA	DEA	NNP
en-wikipedia-org-4107	2095	2	Diversion	Diversion	NNP
en-wikipedia-org-4107	2095	3	Control	Control	NNP
en-wikipedia-org-4107	2095	4	Division	Division	NNP
en-wikipedia-org-4107	2095	5	.	.	.
en-wikipedia-org-4107	2096	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2096	2	25	25	CD
en-wikipedia-org-4107	2096	3	December	December	NNP
en-wikipedia-org-4107	2096	4	2019	2019	CD
en-wikipedia-org-4107	2096	5	.	.	.
en-wikipedia-org-4107	2097	1	^	^	NFP
en-wikipedia-org-4107	2097	2	Gyenis	Gyenis	NNP
en-wikipedia-org-4107	2097	3	A.	A.	NNP
en-wikipedia-org-4107	2098	1	"	"	``
en-wikipedia-org-4107	2098	2	Forty	forty	CD
en-wikipedia-org-4107	2098	3	Years	Years	NNPS
en-wikipedia-org-4107	2098	4	of	of	IN
en-wikipedia-org-4107	2098	5	On	on	IN
en-wikipedia-org-4107	2098	6	the	the	DT
en-wikipedia-org-4107	2098	7	Road	Road	NNP
en-wikipedia-org-4107	2098	8	1957–1997	1957–1997	CD
en-wikipedia-org-4107	2098	9	"	"	''
en-wikipedia-org-4107	2098	10	.	.	.
en-wikipedia-org-4107	2099	1	wordsareimportant.com	wordsareimportant.com	ADD
en-wikipedia-org-4107	2099	2	.	.	.
en-wikipedia-org-4107	2100	1	DHARMA	DHARMA	NNP
en-wikipedia-org-4107	2100	2	beat	beat	NN
en-wikipedia-org-4107	2100	3	.	.	.
en-wikipedia-org-4107	2101	1	Archived	archived	JJ
en-wikipedia-org-4107	2101	2	from	from	IN
en-wikipedia-org-4107	2101	3	the	the	DT
en-wikipedia-org-4107	2101	4	original	original	NN
en-wikipedia-org-4107	2101	5	on	on	IN
en-wikipedia-org-4107	2101	6	14	14	CD
en-wikipedia-org-4107	2101	7	February	February	NNP
en-wikipedia-org-4107	2101	8	2008	2008	CD
en-wikipedia-org-4107	2101	9	.	.	.
en-wikipedia-org-4107	2102	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	2102	2	18	18	CD
en-wikipedia-org-4107	2102	3	March	March	NNP
en-wikipedia-org-4107	2102	4	2008	2008	CD
en-wikipedia-org-4107	2102	5	.	.	.
en-wikipedia-org-4107	2103	1	^	^	NNP
en-wikipedia-org-4107	2103	2	Wilson	Wilson	NNP
en-wikipedia-org-4107	2103	3	A	A	NNP
en-wikipedia-org-4107	2103	4	(	(	-LRB-
en-wikipedia-org-4107	2103	5	2008	2008	CD
en-wikipedia-org-4107	2103	6	)	)	-RRB-
en-wikipedia-org-4107	2103	7	.	.	.
en-wikipedia-org-4107	2104	1	"	"	``
en-wikipedia-org-4107	2104	2	Mixing	mix	VBG
en-wikipedia-org-4107	2104	3	the	the	DT
en-wikipedia-org-4107	2104	4	Medicine	medicine	NN
en-wikipedia-org-4107	2104	5	:	:	:
en-wikipedia-org-4107	2104	6	The	the	DT
en-wikipedia-org-4107	2104	7	unintended	unintended	JJ
en-wikipedia-org-4107	2104	8	consequence	consequence	NN
en-wikipedia-org-4107	2104	9	of	of	IN
en-wikipedia-org-4107	2104	10	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	2104	11	control	control	NN
en-wikipedia-org-4107	2104	12	on	on	IN
en-wikipedia-org-4107	2104	13	the	the	DT
en-wikipedia-org-4107	2104	14	Northern	Northern	NNP
en-wikipedia-org-4107	2104	15	Soul	Soul	NNP
en-wikipedia-org-4107	2104	16	Scene	Scene	NNP
en-wikipedia-org-4107	2104	17	"	"	''
en-wikipedia-org-4107	2104	18	(	(	-LRB-
en-wikipedia-org-4107	2104	19	PDF	PDF	NNP
en-wikipedia-org-4107	2104	20	)	)	-RRB-
en-wikipedia-org-4107	2104	21	.	.	.
en-wikipedia-org-4107	2105	1	Internet	Internet	NNP
en-wikipedia-org-4107	2105	2	Journal	Journal	NNP
en-wikipedia-org-4107	2105	3	of	of	IN
en-wikipedia-org-4107	2105	4	Criminology	Criminology	NNP
en-wikipedia-org-4107	2105	5	.	.	.
en-wikipedia-org-4107	2106	1	Archived	archived	JJ
en-wikipedia-org-4107	2106	2	from	from	IN
en-wikipedia-org-4107	2106	3	the	the	DT
en-wikipedia-org-4107	2106	4	original	original	JJ
en-wikipedia-org-4107	2106	5	(	(	-LRB-
en-wikipedia-org-4107	2106	6	PDF	PDF	NNP
en-wikipedia-org-4107	2106	7	)	)	-RRB-
en-wikipedia-org-4107	2106	8	on	on	IN
en-wikipedia-org-4107	2106	9	13	13	CD
en-wikipedia-org-4107	2106	10	July	July	NNP
en-wikipedia-org-4107	2106	11	2011	2011	CD
en-wikipedia-org-4107	2106	12	.	.	.
en-wikipedia-org-4107	2107	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2107	2	25	25	CD
en-wikipedia-org-4107	2107	3	May	May	NNP
en-wikipedia-org-4107	2107	4	2013	2013	CD
en-wikipedia-org-4107	2107	5	.	.	.
en-wikipedia-org-4107	2108	1	^	^	NNP
en-wikipedia-org-4107	2108	2	Hill	Hill	NNP
en-wikipedia-org-4107	2108	3	J	J	NNP
en-wikipedia-org-4107	2108	4	(	(	-LRB-
en-wikipedia-org-4107	2108	5	4	4	CD
en-wikipedia-org-4107	2108	6	June	June	NNP
en-wikipedia-org-4107	2108	7	2004	2004	CD
en-wikipedia-org-4107	2108	8	)	)	-RRB-
en-wikipedia-org-4107	2108	9	.	.	.
en-wikipedia-org-4107	2109	1	"	"	``
en-wikipedia-org-4107	2109	2	Paul	Paul	NNP
en-wikipedia-org-4107	2109	3	Erdos	Erdos	NNP
en-wikipedia-org-4107	2109	4	,	,	,
en-wikipedia-org-4107	2109	5	Mathematical	Mathematical	NNP
en-wikipedia-org-4107	2109	6	Genius	Genius	NNP
en-wikipedia-org-4107	2109	7	,	,	,
en-wikipedia-org-4107	2109	8	Human	Human	NNP
en-wikipedia-org-4107	2109	9	(	(	-LRB-
en-wikipedia-org-4107	2109	10	In	in	IN
en-wikipedia-org-4107	2109	11	That	that	DT
en-wikipedia-org-4107	2109	12	Order	order	NN
en-wikipedia-org-4107	2109	13	)	)	-RRB-
en-wikipedia-org-4107	2109	14	"	"	''
en-wikipedia-org-4107	2109	15	(	(	-LRB-
en-wikipedia-org-4107	2109	16	PDF	PDF	NNP
en-wikipedia-org-4107	2109	17	)	)	-RRB-
en-wikipedia-org-4107	2109	18	.	.	.
en-wikipedia-org-4107	2110	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2110	2	2	2	CD
en-wikipedia-org-4107	2110	3	November	November	NNP
en-wikipedia-org-4107	2110	4	2013	2013	CD
en-wikipedia-org-4107	2110	5	.	.	.
en-wikipedia-org-4107	2111	1	^	^	NNP
en-wikipedia-org-4107	2111	2	a	a	DT
en-wikipedia-org-4107	2111	3	b	b	NNP
en-wikipedia-org-4107	2111	4	c	c	NN
en-wikipedia-org-4107	2111	5	Mohan	Mohan	NNP
en-wikipedia-org-4107	2111	6	J	J	NNP
en-wikipedia-org-4107	2111	7	,	,	,
en-wikipedia-org-4107	2111	8	ed	ed	NNP
en-wikipedia-org-4107	2111	9	.	.	.
en-wikipedia-org-4107	2112	1	(	(	-LRB-
en-wikipedia-org-4107	2112	2	June	June	NNP
en-wikipedia-org-4107	2112	3	2014	2014	CD
en-wikipedia-org-4107	2112	4	)	)	-RRB-
en-wikipedia-org-4107	2112	5	.	.	.
en-wikipedia-org-4107	2113	1	"	"	``
en-wikipedia-org-4107	2113	2	World	World	NNP
en-wikipedia-org-4107	2113	3	Drug	Drug	NNP
en-wikipedia-org-4107	2113	4	Report	Report	NNP
en-wikipedia-org-4107	2113	5	2014	2014	CD
en-wikipedia-org-4107	2113	6	"	"	''
en-wikipedia-org-4107	2113	7	(	(	-LRB-
en-wikipedia-org-4107	2113	8	PDF	PDF	NNP
en-wikipedia-org-4107	2113	9	)	)	-RRB-
en-wikipedia-org-4107	2113	10	.	.	.
en-wikipedia-org-4107	2114	1	United	United	NNP
en-wikipedia-org-4107	2114	2	Nations	Nations	NNP
en-wikipedia-org-4107	2114	3	Office	Office	NNP
en-wikipedia-org-4107	2114	4	on	on	IN
en-wikipedia-org-4107	2114	5	Drugs	Drugs	NNPS
en-wikipedia-org-4107	2114	6	and	and	CC
en-wikipedia-org-4107	2114	7	Crime	Crime	NNP
en-wikipedia-org-4107	2114	8	.	.	.
en-wikipedia-org-4107	2115	1	p.	p.	NN
en-wikipedia-org-4107	2115	2	 	  	_SP
en-wikipedia-org-4107	2115	3	3	3	CD
en-wikipedia-org-4107	2115	4	.	.	.
en-wikipedia-org-4107	2116	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2116	2	18	18	CD
en-wikipedia-org-4107	2116	3	August	August	NNP
en-wikipedia-org-4107	2116	4	2014	2014	CD
en-wikipedia-org-4107	2116	5	.	.	.
en-wikipedia-org-4107	2117	1	^	^	FW
en-wikipedia-org-4107	2117	2	"	"	``
en-wikipedia-org-4107	2117	3	Statistical	Statistical	NNP
en-wikipedia-org-4107	2117	4	Bulletin	Bulletin	NNP
en-wikipedia-org-4107	2117	5	2018	2018	CD
en-wikipedia-org-4107	2117	6	 	  	_SP
en-wikipedia-org-4107	2117	7	−	−	NNP
en-wikipedia-org-4107	2117	8	prevalence	prevalence	NN
en-wikipedia-org-4107	2117	9	of	of	IN
en-wikipedia-org-4107	2117	10	drug	drug	NN
en-wikipedia-org-4107	2117	11	use	use	NN
en-wikipedia-org-4107	2117	12	"	"	''
en-wikipedia-org-4107	2117	13	.	.	.
en-wikipedia-org-4107	2118	1	European	European	NNP
en-wikipedia-org-4107	2118	2	Monitoring	Monitoring	NNP
en-wikipedia-org-4107	2118	3	Centre	Centre	NNP
en-wikipedia-org-4107	2118	4	for	for	IN
en-wikipedia-org-4107	2118	5	Drugs	Drugs	NNP
en-wikipedia-org-4107	2118	6	and	and	CC
en-wikipedia-org-4107	2118	7	Drug	Drug	NNP
en-wikipedia-org-4107	2118	8	Addiction	Addiction	NNP
en-wikipedia-org-4107	2118	9	.	.	.
en-wikipedia-org-4107	2119	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	2119	2	5	5	CD
en-wikipedia-org-4107	2119	3	February	February	NNP
en-wikipedia-org-4107	2119	4	2019	2019	CD
en-wikipedia-org-4107	2119	5	.	.	.
en-wikipedia-org-4107	2120	1	^	^	NNP
en-wikipedia-org-4107	2120	2	a	a	DT
en-wikipedia-org-4107	2120	3	b	b	NNP
en-wikipedia-org-4107	2120	4	European	european	JJ
en-wikipedia-org-4107	2120	5	drug	drug	NN
en-wikipedia-org-4107	2120	6	report	report	NN
en-wikipedia-org-4107	2120	7	2014	2014	CD
en-wikipedia-org-4107	2120	8	:	:	:
en-wikipedia-org-4107	2120	9	Trends	trend	NNS
en-wikipedia-org-4107	2120	10	and	and	CC
en-wikipedia-org-4107	2120	11	developments	development	NNS
en-wikipedia-org-4107	2120	12	(	(	-LRB-
en-wikipedia-org-4107	2120	13	PDF	PDF	NNP
en-wikipedia-org-4107	2120	14	)	)	-RRB-
en-wikipedia-org-4107	2120	15	(	(	-LRB-
en-wikipedia-org-4107	2120	16	Report	report	NN
en-wikipedia-org-4107	2120	17	)	)	-RRB-
en-wikipedia-org-4107	2120	18	.	.	.
en-wikipedia-org-4107	2121	1	Lisbon	Lisbon	NNP
en-wikipedia-org-4107	2121	2	,	,	,
en-wikipedia-org-4107	2121	3	Portugal	Portugal	NNP
en-wikipedia-org-4107	2121	4	:	:	:
en-wikipedia-org-4107	2121	5	European	European	NNP
en-wikipedia-org-4107	2121	6	Monitoring	Monitoring	NNP
en-wikipedia-org-4107	2121	7	Centre	Centre	NNP
en-wikipedia-org-4107	2121	8	for	for	IN
en-wikipedia-org-4107	2121	9	Drugs	Drugs	NNP
en-wikipedia-org-4107	2121	10	and	and	CC
en-wikipedia-org-4107	2121	11	Drug	Drug	NNP
en-wikipedia-org-4107	2121	12	Addiction	Addiction	NNP
en-wikipedia-org-4107	2121	13	.	.	.
en-wikipedia-org-4107	2122	1	May	May	NNP
en-wikipedia-org-4107	2122	2	2014	2014	CD
en-wikipedia-org-4107	2122	3	.	.	.
en-wikipedia-org-4107	2122	4	pp	pp	NNP
en-wikipedia-org-4107	2122	5	.	.	.
en-wikipedia-org-4107	2123	1	13	13	CD
en-wikipedia-org-4107	2123	2	,	,	,
en-wikipedia-org-4107	2123	3	24	24	CD
en-wikipedia-org-4107	2123	4	.	.	.
en-wikipedia-org-4107	2123	5	doi:10.2810/32306	doi:10.2810/32306	NNP
en-wikipedia-org-4107	2123	6	.	.	.
en-wikipedia-org-4107	2124	1	ISSN	issn	NN
en-wikipedia-org-4107	2124	2	 	  	_SP
en-wikipedia-org-4107	2124	3	2314	2314	CD
en-wikipedia-org-4107	2124	4	-	-	SYM
en-wikipedia-org-4107	2124	5	9086	9086	CD
en-wikipedia-org-4107	2124	6	.	.	.
en-wikipedia-org-4107	2125	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2125	2	18	18	CD
en-wikipedia-org-4107	2125	3	August	August	NNP
en-wikipedia-org-4107	2125	4	2014	2014	CD
en-wikipedia-org-4107	2125	5	.	.	.
en-wikipedia-org-4107	2126	1	1.2	1.2	CD
en-wikipedia-org-4107	2126	2	million	million	CD
en-wikipedia-org-4107	2126	3	or	or	CC
en-wikipedia-org-4107	2126	4	0.9	0.9	CD
en-wikipedia-org-4107	2126	5	%	%	NN
en-wikipedia-org-4107	2126	6	of	of	IN
en-wikipedia-org-4107	2126	7	young	young	JJ
en-wikipedia-org-4107	2126	8	adults	adult	NNS
en-wikipedia-org-4107	2126	9	(	(	-LRB-
en-wikipedia-org-4107	2126	10	15–34	15–34	CD
en-wikipedia-org-4107	2126	11	)	)	-RRB-
en-wikipedia-org-4107	2126	12	used	use	VBN
en-wikipedia-org-4107	2126	13	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	2126	14	in	in	IN
en-wikipedia-org-4107	2126	15	the	the	DT
en-wikipedia-org-4107	2126	16	last	last	JJ
en-wikipedia-org-4107	2126	17	year	year	NN
en-wikipedia-org-4107	2126	18	^	^	NN
en-wikipedia-org-4107	2126	19	United	United	NNP
en-wikipedia-org-4107	2126	20	Nations	Nations	NNP
en-wikipedia-org-4107	2126	21	Office	Office	NNP
en-wikipedia-org-4107	2126	22	on	on	IN
en-wikipedia-org-4107	2126	23	Drugs	Drugs	NNPS
en-wikipedia-org-4107	2126	24	and	and	CC
en-wikipedia-org-4107	2126	25	Crime	Crime	NNP
en-wikipedia-org-4107	2126	26	(	(	-LRB-
en-wikipedia-org-4107	2126	27	2007	2007	CD
en-wikipedia-org-4107	2126	28	)	)	-RRB-
en-wikipedia-org-4107	2126	29	.	.	.
en-wikipedia-org-4107	2127	1	Preventing	Preventing	NNP
en-wikipedia-org-4107	2127	2	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2127	3	-	-	HYPH
en-wikipedia-org-4107	2127	4	type	type	NN
en-wikipedia-org-4107	2127	5	Stimulant	Stimulant	NNP
en-wikipedia-org-4107	2127	6	Use	Use	NNP
en-wikipedia-org-4107	2127	7	Among	among	IN
en-wikipedia-org-4107	2127	8	Young	young	JJ
en-wikipedia-org-4107	2127	9	People	People	NNS
en-wikipedia-org-4107	2127	10	:	:	:
en-wikipedia-org-4107	2127	11	A	a	DT
en-wikipedia-org-4107	2127	12	Policy	Policy	NNP
en-wikipedia-org-4107	2127	13	and	and	CC
en-wikipedia-org-4107	2127	14	Programming	Programming	NNP
en-wikipedia-org-4107	2127	15	Guide	Guide	NNP
en-wikipedia-org-4107	2127	16	(	(	-LRB-
en-wikipedia-org-4107	2127	17	PDF	PDF	NNP
en-wikipedia-org-4107	2127	18	)	)	-RRB-
en-wikipedia-org-4107	2127	19	.	.	.
en-wikipedia-org-4107	2128	1	New	New	NNP
en-wikipedia-org-4107	2128	2	York	York	NNP
en-wikipedia-org-4107	2128	3	,	,	,
en-wikipedia-org-4107	2128	4	USA	USA	NNP
en-wikipedia-org-4107	2128	5	:	:	:
en-wikipedia-org-4107	2128	6	United	United	NNP
en-wikipedia-org-4107	2128	7	Nations	Nations	NNP
en-wikipedia-org-4107	2128	8	.	.	.
en-wikipedia-org-4107	2129	1	ISBN	ISBN	NNP
en-wikipedia-org-4107	2129	2	 	  	_SP
en-wikipedia-org-4107	2129	3	9789211482232	9789211482232	CD
en-wikipedia-org-4107	2129	4	.	.	.
en-wikipedia-org-4107	2130	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2130	2	11	11	CD
en-wikipedia-org-4107	2130	3	November	November	NNP
en-wikipedia-org-4107	2130	4	2013	2013	CD
en-wikipedia-org-4107	2130	5	.	.	.
en-wikipedia-org-4107	2131	1	^	^	FW
en-wikipedia-org-4107	2131	2	"	"	``
en-wikipedia-org-4107	2131	3	List	List	NNP
en-wikipedia-org-4107	2131	4	of	of	IN
en-wikipedia-org-4107	2131	5	psychotropic	psychotropic	JJ
en-wikipedia-org-4107	2131	6	substances	substance	NNS
en-wikipedia-org-4107	2131	7	under	under	IN
en-wikipedia-org-4107	2131	8	international	international	JJ
en-wikipedia-org-4107	2131	9	control	control	NN
en-wikipedia-org-4107	2131	10	"	"	''
en-wikipedia-org-4107	2131	11	(	(	-LRB-
en-wikipedia-org-4107	2131	12	PDF	PDF	NNP
en-wikipedia-org-4107	2131	13	)	)	-RRB-
en-wikipedia-org-4107	2131	14	.	.	.
en-wikipedia-org-4107	2132	1	International	International	NNP
en-wikipedia-org-4107	2132	2	Narcotics	Narcotics	NNP
en-wikipedia-org-4107	2132	3	Control	Control	NNP
en-wikipedia-org-4107	2132	4	Board	Board	NNP
en-wikipedia-org-4107	2132	5	.	.	.
en-wikipedia-org-4107	2133	1	United	United	NNP
en-wikipedia-org-4107	2133	2	Nations	Nations	NNP
en-wikipedia-org-4107	2133	3	.	.	.
en-wikipedia-org-4107	2134	1	August	August	NNP
en-wikipedia-org-4107	2134	2	2003	2003	CD
en-wikipedia-org-4107	2134	3	.	.	.
en-wikipedia-org-4107	2135	1	Archived	archived	JJ
en-wikipedia-org-4107	2135	2	from	from	IN
en-wikipedia-org-4107	2135	3	the	the	DT
en-wikipedia-org-4107	2135	4	original	original	JJ
en-wikipedia-org-4107	2135	5	(	(	-LRB-
en-wikipedia-org-4107	2135	6	PDF	PDF	NNP
en-wikipedia-org-4107	2135	7	)	)	-RRB-
en-wikipedia-org-4107	2135	8	on	on	IN
en-wikipedia-org-4107	2135	9	5	5	CD
en-wikipedia-org-4107	2135	10	December	December	NNP
en-wikipedia-org-4107	2135	11	2005	2005	CD
en-wikipedia-org-4107	2135	12	.	.	.
en-wikipedia-org-4107	2136	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2136	2	19	19	CD
en-wikipedia-org-4107	2136	3	November	November	NNP
en-wikipedia-org-4107	2136	4	2005	2005	CD
en-wikipedia-org-4107	2136	5	.	.	.
en-wikipedia-org-4107	2137	1	^	^	NFP
en-wikipedia-org-4107	2137	2	Park	Park	NNP
en-wikipedia-org-4107	2137	3	Jin	Jin	NNP
en-wikipedia-org-4107	2137	4	-	-	HYPH
en-wikipedia-org-4107	2137	5	seng	seng	NNP
en-wikipedia-org-4107	2137	6	(	(	-LRB-
en-wikipedia-org-4107	2137	7	25	25	CD
en-wikipedia-org-4107	2137	8	May	May	NNP
en-wikipedia-org-4107	2137	9	2012	2012	CD
en-wikipedia-org-4107	2137	10	)	)	-RRB-
en-wikipedia-org-4107	2137	11	.	.	.
en-wikipedia-org-4107	2138	1	"	"	``
en-wikipedia-org-4107	2138	2	Moving	move	VBG
en-wikipedia-org-4107	2138	3	to	to	IN
en-wikipedia-org-4107	2138	4	Korea	Korea	NNP
en-wikipedia-org-4107	2138	5	brings	bring	VBZ
en-wikipedia-org-4107	2138	6	medical	medical	JJ
en-wikipedia-org-4107	2138	7	,	,	,
en-wikipedia-org-4107	2138	8	social	social	JJ
en-wikipedia-org-4107	2138	9	changes	change	NNS
en-wikipedia-org-4107	2138	10	"	"	''
en-wikipedia-org-4107	2138	11	.	.	.
en-wikipedia-org-4107	2139	1	The	the	DT
en-wikipedia-org-4107	2139	2	Korean	Korean	NNP
en-wikipedia-org-4107	2139	3	Times	Times	NNP
en-wikipedia-org-4107	2139	4	.	.	.
en-wikipedia-org-4107	2140	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2140	2	14	14	CD
en-wikipedia-org-4107	2140	3	November	November	NNP
en-wikipedia-org-4107	2140	4	2013	2013	CD
en-wikipedia-org-4107	2140	5	.	.	.
en-wikipedia-org-4107	2141	1	^	^	FW
en-wikipedia-org-4107	2141	2	"	"	``
en-wikipedia-org-4107	2141	3	Importing	import	VBG
en-wikipedia-org-4107	2141	4	or	or	CC
en-wikipedia-org-4107	2141	5	Bringing	Bringing	NNP
en-wikipedia-org-4107	2141	6	Medication	Medication	NNP
en-wikipedia-org-4107	2141	7	into	into	IN
en-wikipedia-org-4107	2141	8	Japan	Japan	NNP
en-wikipedia-org-4107	2141	9	for	for	IN
en-wikipedia-org-4107	2141	10	Personal	Personal	NNP
en-wikipedia-org-4107	2141	11	Use	Use	NNP
en-wikipedia-org-4107	2141	12	"	"	''
en-wikipedia-org-4107	2141	13	.	.	.
en-wikipedia-org-4107	2142	1	Japanese	Japanese	NNP
en-wikipedia-org-4107	2142	2	Ministry	Ministry	NNP
en-wikipedia-org-4107	2142	3	of	of	IN
en-wikipedia-org-4107	2142	4	Health	Health	NNP
en-wikipedia-org-4107	2142	5	,	,	,
en-wikipedia-org-4107	2142	6	Labour	Labour	NNP
en-wikipedia-org-4107	2142	7	and	and	CC
en-wikipedia-org-4107	2142	8	Welfare	Welfare	NNP
en-wikipedia-org-4107	2142	9	.	.	.
en-wikipedia-org-4107	2143	1	1	1	CD
en-wikipedia-org-4107	2143	2	April	April	NNP
en-wikipedia-org-4107	2143	3	2004	2004	CD
en-wikipedia-org-4107	2143	4	.	.	.
en-wikipedia-org-4107	2144	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	2144	2	3	3	CD
en-wikipedia-org-4107	2144	3	November	November	NNP
en-wikipedia-org-4107	2144	4	2013	2013	CD
en-wikipedia-org-4107	2144	5	.	.	.
en-wikipedia-org-4107	2145	1	^	^	FW
en-wikipedia-org-4107	2145	2	"	"	``
en-wikipedia-org-4107	2145	3	Controlled	control	VBN
en-wikipedia-org-4107	2145	4	Drugs	Drugs	NNPS
en-wikipedia-org-4107	2145	5	and	and	CC
en-wikipedia-org-4107	2145	6	Substances	Substances	NNPS
en-wikipedia-org-4107	2145	7	Act	Act	NNP
en-wikipedia-org-4107	2145	8	"	"	''
en-wikipedia-org-4107	2145	9	.	.	.
en-wikipedia-org-4107	2146	1	Canadian	Canadian	NNP
en-wikipedia-org-4107	2146	2	Justice	Justice	NNP
en-wikipedia-org-4107	2146	3	Laws	Laws	NNP
en-wikipedia-org-4107	2146	4	Website	Website	NNP
en-wikipedia-org-4107	2146	5	.	.	.
en-wikipedia-org-4107	2147	1	Government	Government	NNP
en-wikipedia-org-4107	2147	2	of	of	IN
en-wikipedia-org-4107	2147	3	Canada	Canada	NNP
en-wikipedia-org-4107	2147	4	.	.	.
en-wikipedia-org-4107	2148	1	Archived	archived	JJ
en-wikipedia-org-4107	2148	2	from	from	IN
en-wikipedia-org-4107	2148	3	the	the	DT
en-wikipedia-org-4107	2148	4	original	original	NN
en-wikipedia-org-4107	2148	5	on	on	IN
en-wikipedia-org-4107	2148	6	22	22	CD
en-wikipedia-org-4107	2148	7	November	November	NNP
en-wikipedia-org-4107	2148	8	2013	2013	CD
en-wikipedia-org-4107	2148	9	.	.	.
en-wikipedia-org-4107	2149	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2149	2	11	11	CD
en-wikipedia-org-4107	2149	3	November	November	NNP
en-wikipedia-org-4107	2149	4	2013	2013	CD
en-wikipedia-org-4107	2149	5	.	.	.
en-wikipedia-org-4107	2150	1	^	^	FW
en-wikipedia-org-4107	2150	2	"	"	``
en-wikipedia-org-4107	2150	3	Opiumwet	opiumwet	JJ
en-wikipedia-org-4107	2150	4	"	"	''
en-wikipedia-org-4107	2150	5	.	.	.
en-wikipedia-org-4107	2151	1	Government	government	NN
en-wikipedia-org-4107	2151	2	of	of	IN
en-wikipedia-org-4107	2151	3	the	the	DT
en-wikipedia-org-4107	2151	4	Netherlands	Netherlands	NNP
en-wikipedia-org-4107	2151	5	.	.	.
en-wikipedia-org-4107	2152	1	Retrieved	Retrieved	NNP
en-wikipedia-org-4107	2152	2	3	3	CD
en-wikipedia-org-4107	2152	3	April	April	NNP
en-wikipedia-org-4107	2152	4	2015	2015	CD
en-wikipedia-org-4107	2152	5	.	.	.
en-wikipedia-org-4107	2153	1	^	^	FW
en-wikipedia-org-4107	2153	2	"	"	``
en-wikipedia-org-4107	2153	3	Schedule	schedule	NN
en-wikipedia-org-4107	2153	4	8	8	CD
en-wikipedia-org-4107	2153	5	"	"	''
en-wikipedia-org-4107	2153	6	.	.	.
en-wikipedia-org-4107	2154	1	Poisons	poison	NNS
en-wikipedia-org-4107	2154	2	Standard	Standard	NNP
en-wikipedia-org-4107	2154	3	.	.	.
en-wikipedia-org-4107	2155	1	Australian	Australian	NNP
en-wikipedia-org-4107	2155	2	Government	Government	NNP
en-wikipedia-org-4107	2155	3	Department	Department	NNP
en-wikipedia-org-4107	2155	4	of	of	IN
en-wikipedia-org-4107	2155	5	Health	Health	NNP
en-wikipedia-org-4107	2155	6	.	.	.
en-wikipedia-org-4107	2156	1	October	October	NNP
en-wikipedia-org-4107	2156	2	2015	2015	CD
en-wikipedia-org-4107	2156	3	.	.	.
en-wikipedia-org-4107	2157	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2157	2	15	15	CD
en-wikipedia-org-4107	2157	3	December	December	NNP
en-wikipedia-org-4107	2157	4	2015	2015	CD
en-wikipedia-org-4107	2157	5	.	.	.
en-wikipedia-org-4107	2158	1	^	^	FW
en-wikipedia-org-4107	2158	2	"	"	``
en-wikipedia-org-4107	2158	3	Table	table	NN
en-wikipedia-org-4107	2158	4	of	of	IN
en-wikipedia-org-4107	2158	5	controlled	control	VBN
en-wikipedia-org-4107	2158	6	Narcotic	narcotic	JJ
en-wikipedia-org-4107	2158	7	Drugs	drug	NNS
en-wikipedia-org-4107	2158	8	under	under	IN
en-wikipedia-org-4107	2158	9	the	the	DT
en-wikipedia-org-4107	2158	10	Thai	Thai	NNP
en-wikipedia-org-4107	2158	11	Narcotics	Narcotics	NNP
en-wikipedia-org-4107	2158	12	Act	Act	NNP
en-wikipedia-org-4107	2158	13	"	"	''
en-wikipedia-org-4107	2158	14	(	(	-LRB-
en-wikipedia-org-4107	2158	15	PDF	PDF	NNP
en-wikipedia-org-4107	2158	16	)	)	-RRB-
en-wikipedia-org-4107	2158	17	.	.	.
en-wikipedia-org-4107	2159	1	Thailand	Thailand	NNP
en-wikipedia-org-4107	2159	2	Food	Food	NNP
en-wikipedia-org-4107	2159	3	and	and	CC
en-wikipedia-org-4107	2159	4	Drug	Drug	NNP
en-wikipedia-org-4107	2159	5	Administration	Administration	NNP
en-wikipedia-org-4107	2159	6	.	.	.
en-wikipedia-org-4107	2160	1	22	22	CD
en-wikipedia-org-4107	2160	2	May	May	NNP
en-wikipedia-org-4107	2160	3	2013	2013	CD
en-wikipedia-org-4107	2160	4	.	.	.
en-wikipedia-org-4107	2161	1	Archived	archived	JJ
en-wikipedia-org-4107	2161	2	from	from	IN
en-wikipedia-org-4107	2161	3	the	the	DT
en-wikipedia-org-4107	2161	4	original	original	JJ
en-wikipedia-org-4107	2161	5	(	(	-LRB-
en-wikipedia-org-4107	2161	6	PDF	PDF	NNP
en-wikipedia-org-4107	2161	7	)	)	-RRB-
en-wikipedia-org-4107	2161	8	on	on	IN
en-wikipedia-org-4107	2161	9	8	8	CD
en-wikipedia-org-4107	2161	10	March	March	NNP
en-wikipedia-org-4107	2161	11	2014	2014	CD
en-wikipedia-org-4107	2161	12	.	.	.
en-wikipedia-org-4107	2162	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2162	2	11	11	CD
en-wikipedia-org-4107	2162	3	November	November	NNP
en-wikipedia-org-4107	2162	4	2013	2013	CD
en-wikipedia-org-4107	2162	5	.	.	.
en-wikipedia-org-4107	2163	1	^	^	FW
en-wikipedia-org-4107	2163	2	"	"	``
en-wikipedia-org-4107	2163	3	Class	Class	NNP
en-wikipedia-org-4107	2163	4	A	A	NNP
en-wikipedia-org-4107	2163	5	,	,	,
en-wikipedia-org-4107	2163	6	B	b	NN
en-wikipedia-org-4107	2163	7	and	and	CC
en-wikipedia-org-4107	2163	8	C	C	NNP
en-wikipedia-org-4107	2163	9	drugs	drug	NNS
en-wikipedia-org-4107	2163	10	"	"	''
en-wikipedia-org-4107	2163	11	.	.	.
en-wikipedia-org-4107	2164	1	Home	Home	NNP
en-wikipedia-org-4107	2164	2	Office	Office	NNP
en-wikipedia-org-4107	2164	3	,	,	,
en-wikipedia-org-4107	2164	4	Government	Government	NNP
en-wikipedia-org-4107	2164	5	of	of	IN
en-wikipedia-org-4107	2164	6	the	the	DT
en-wikipedia-org-4107	2164	7	United	United	NNP
en-wikipedia-org-4107	2164	8	Kingdom	Kingdom	NNP
en-wikipedia-org-4107	2164	9	.	.	.
en-wikipedia-org-4107	2165	1	Archived	archived	JJ
en-wikipedia-org-4107	2165	2	from	from	IN
en-wikipedia-org-4107	2165	3	the	the	DT
en-wikipedia-org-4107	2165	4	original	original	NN
en-wikipedia-org-4107	2165	5	on	on	IN
en-wikipedia-org-4107	2165	6	4	4	CD
en-wikipedia-org-4107	2165	7	August	August	NNP
en-wikipedia-org-4107	2165	8	2007	2007	CD
en-wikipedia-org-4107	2165	9	.	.	.
en-wikipedia-org-4107	2166	1	Retrieved	retrieved	JJ
en-wikipedia-org-4107	2166	2	23	23	CD
en-wikipedia-org-4107	2166	3	July	July	NNP
en-wikipedia-org-4107	2166	4	2007	2007	CD
en-wikipedia-org-4107	2166	5	.	.	.
en-wikipedia-org-4107	2167	1	^	^	NNP
en-wikipedia-org-4107	2167	2	a	a	DT
en-wikipedia-org-4107	2167	3	b	b	NNP
en-wikipedia-org-4107	2167	4	"	"	``
en-wikipedia-org-4107	2167	5	Drug	Drug	NNP
en-wikipedia-org-4107	2167	6	Approval	Approval	NNP
en-wikipedia-org-4107	2167	7	Package	Package	NNP
en-wikipedia-org-4107	2167	8	:	:	:
en-wikipedia-org-4107	2167	9	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2167	10	(	(	-LRB-
en-wikipedia-org-4107	2167	11	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2167	12	)	)	-RRB-
en-wikipedia-org-4107	2167	13	"	"	''
en-wikipedia-org-4107	2167	14	.	.	.
en-wikipedia-org-4107	2168	1	United	United	NNP
en-wikipedia-org-4107	2168	2	States	States	NNP
en-wikipedia-org-4107	2168	3	Food	Food	NNP
en-wikipedia-org-4107	2168	4	and	and	CC
en-wikipedia-org-4107	2168	5	Drug	Drug	NNP
en-wikipedia-org-4107	2168	6	Administration	Administration	NNP
en-wikipedia-org-4107	2168	7	.	.	.
en-wikipedia-org-4107	2169	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2169	2	22	22	CD
en-wikipedia-org-4107	2169	3	December	December	NNP
en-wikipedia-org-4107	2169	4	2019	2019	CD
en-wikipedia-org-4107	2169	5	.	.	.
en-wikipedia-org-4107	2170	1	^	^	NNP
en-wikipedia-org-4107	2170	2	a	a	DT
en-wikipedia-org-4107	2170	3	b	b	NNP
en-wikipedia-org-4107	2170	4	"	"	``
en-wikipedia-org-4107	2170	5	Adzenys	Adzenys	NNP
en-wikipedia-org-4107	2170	6	XR	XR	NNP
en-wikipedia-org-4107	2170	7	-	-	HYPH
en-wikipedia-org-4107	2170	8	ODT-	ODT-	NNP
en-wikipedia-org-4107	2170	9	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2170	10	tablet	tablet	NN
en-wikipedia-org-4107	2170	11	,	,	,
en-wikipedia-org-4107	2170	12	orally	orally	RB
en-wikipedia-org-4107	2170	13	disintegrating	disintegrate	VBG
en-wikipedia-org-4107	2170	14	"	"	''
en-wikipedia-org-4107	2170	15	.	.	.
en-wikipedia-org-4107	2171	1	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	2171	2	.	.	.
en-wikipedia-org-4107	2172	1	Neos	Neos	NNP
en-wikipedia-org-4107	2172	2	Therapeutics	Therapeutics	NNP
en-wikipedia-org-4107	2172	3	,	,	,
en-wikipedia-org-4107	2172	4	Inc.	Inc.	NNP
en-wikipedia-org-4107	2172	5	9	9	CD
en-wikipedia-org-4107	2172	6	February	February	NNP
en-wikipedia-org-4107	2172	7	2018	2018	CD
en-wikipedia-org-4107	2172	8	.	.	.
en-wikipedia-org-4107	2173	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2173	2	22	22	CD
en-wikipedia-org-4107	2173	3	December	December	NNP
en-wikipedia-org-4107	2173	4	2019	2019	CD
en-wikipedia-org-4107	2173	5	.	.	.
en-wikipedia-org-4107	2174	1	ADZENYS	ADZENYS	NNP
en-wikipedia-org-4107	2174	2	XR	XR	NNP
en-wikipedia-org-4107	2174	3	-	-	HYPH
en-wikipedia-org-4107	2174	4	ODT	ODT	NNP
en-wikipedia-org-4107	2174	5	(	(	-LRB-
en-wikipedia-org-4107	2174	6	amphetamine	amphetamine	VB
en-wikipedia-org-4107	2174	7	extended	extend	VBN
en-wikipedia-org-4107	2174	8	-	-	HYPH
en-wikipedia-org-4107	2174	9	release	release	NN
en-wikipedia-org-4107	2174	10	orally	orally	RB
en-wikipedia-org-4107	2174	11	disintegrating	disintegrate	VBG
en-wikipedia-org-4107	2174	12	tablet	tablet	NN
en-wikipedia-org-4107	2174	13	)	)	-RRB-
en-wikipedia-org-4107	2174	14	contains	contain	VBZ
en-wikipedia-org-4107	2174	15	a	a	DT
en-wikipedia-org-4107	2174	16	3	3	CD
en-wikipedia-org-4107	2174	17	to	to	IN
en-wikipedia-org-4107	2174	18	1	1	CD
en-wikipedia-org-4107	2174	19	ratio	ratio	NN
en-wikipedia-org-4107	2174	20	of	of	IN
en-wikipedia-org-4107	2174	21	d-	d-	NN
en-wikipedia-org-4107	2174	22	to	to	IN
en-wikipedia-org-4107	2174	23	l	l	NN
en-wikipedia-org-4107	2174	24	-	-	HYPH
en-wikipedia-org-4107	2174	25	amphetamine	amphetamine	NNP
en-wikipedia-org-4107	2174	26	,	,	,
en-wikipedia-org-4107	2174	27	a	a	DT
en-wikipedia-org-4107	2174	28	central	central	JJ
en-wikipedia-org-4107	2174	29	nervous	nervous	JJ
en-wikipedia-org-4107	2174	30	system	system	NN
en-wikipedia-org-4107	2174	31	stimulant	stimulant	NN
en-wikipedia-org-4107	2174	32	.	.	.
en-wikipedia-org-4107	2175	1	^	^	FW
en-wikipedia-org-4107	2175	2	"	"	``
en-wikipedia-org-4107	2175	3	Mydayis-	Mydayis-	NNP
en-wikipedia-org-4107	2175	4	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	2175	5	sulfate	sulfate	NN
en-wikipedia-org-4107	2175	6	,	,	,
en-wikipedia-org-4107	2175	7	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	2175	8	saccharate	saccharate	NN
en-wikipedia-org-4107	2175	9	,	,	,
en-wikipedia-org-4107	2175	10	amphetamine	amphetamine	VB
en-wikipedia-org-4107	2175	11	aspartate	aspartate	NN
en-wikipedia-org-4107	2175	12	monohydrate	monohydrate	NNP
en-wikipedia-org-4107	2175	13	,	,	,
en-wikipedia-org-4107	2175	14	and	and	CC
en-wikipedia-org-4107	2175	15	amphetamine	amphetamine	VB
en-wikipedia-org-4107	2175	16	sulfate	sulfate	NNP
en-wikipedia-org-4107	2175	17	capsule	capsule	NNP
en-wikipedia-org-4107	2175	18	,	,	,
en-wikipedia-org-4107	2175	19	extended	extended	JJ
en-wikipedia-org-4107	2175	20	release	release	NN
en-wikipedia-org-4107	2175	21	"	"	''
en-wikipedia-org-4107	2175	22	.	.	.
en-wikipedia-org-4107	2176	1	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	2176	2	.	.	.
en-wikipedia-org-4107	2177	1	Shire	Shire	NNP
en-wikipedia-org-4107	2177	2	US	US	NNP
en-wikipedia-org-4107	2177	3	Inc.	Inc.	NNP
en-wikipedia-org-4107	2177	4	11	11	CD
en-wikipedia-org-4107	2177	5	October	October	NNP
en-wikipedia-org-4107	2177	6	2019	2019	CD
en-wikipedia-org-4107	2177	7	.	.	.
en-wikipedia-org-4107	2178	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2178	2	22	22	CD
en-wikipedia-org-4107	2178	3	December	December	NNP
en-wikipedia-org-4107	2178	4	2019	2019	CD
en-wikipedia-org-4107	2178	5	.	.	.
en-wikipedia-org-4107	2179	1	^	^	FW
en-wikipedia-org-4107	2179	2	"	"	``
en-wikipedia-org-4107	2179	3	Drug	Drug	NNP
en-wikipedia-org-4107	2179	4	Approval	Approval	NNP
en-wikipedia-org-4107	2179	5	Package	Package	NNP
en-wikipedia-org-4107	2179	6	:	:	:
en-wikipedia-org-4107	2179	7	Mydayis	Mydayis	NNP
en-wikipedia-org-4107	2179	8	(	(	-LRB-
en-wikipedia-org-4107	2179	9	mixed	mixed	JJ
en-wikipedia-org-4107	2179	10	salts	salt	NNS
en-wikipedia-org-4107	2179	11	of	of	IN
en-wikipedia-org-4107	2179	12	a	a	DT
en-wikipedia-org-4107	2179	13	single	single	JJ
en-wikipedia-org-4107	2179	14	-	-	HYPH
en-wikipedia-org-4107	2179	15	entity	entity	NN
en-wikipedia-org-4107	2179	16	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2179	17	product	product	NN
en-wikipedia-org-4107	2179	18	)	)	-RRB-
en-wikipedia-org-4107	2179	19	"	"	''
en-wikipedia-org-4107	2179	20	.	.	.
en-wikipedia-org-4107	2180	1	United	United	NNP
en-wikipedia-org-4107	2180	2	States	States	NNP
en-wikipedia-org-4107	2180	3	Food	Food	NNP
en-wikipedia-org-4107	2180	4	and	and	CC
en-wikipedia-org-4107	2180	5	Drug	Drug	NNP
en-wikipedia-org-4107	2180	6	Administration	Administration	NNP
en-wikipedia-org-4107	2180	7	.	.	.
en-wikipedia-org-4107	2181	1	6	6	CD
en-wikipedia-org-4107	2181	2	June	June	NNP
en-wikipedia-org-4107	2181	3	2018	2018	CD
en-wikipedia-org-4107	2181	4	.	.	.
en-wikipedia-org-4107	2182	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2182	2	22	22	CD
en-wikipedia-org-4107	2182	3	December	December	NNP
en-wikipedia-org-4107	2182	4	2019	2019	CD
en-wikipedia-org-4107	2182	5	.	.	.
en-wikipedia-org-4107	2183	1	^	^	FW
en-wikipedia-org-4107	2183	2	"	"	``
en-wikipedia-org-4107	2183	3	Adzenys	adzenys	JJ
en-wikipedia-org-4107	2183	4	ER-	ER-	NNP
en-wikipedia-org-4107	2183	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2183	6	suspension	suspension	NN
en-wikipedia-org-4107	2183	7	,	,	,
en-wikipedia-org-4107	2183	8	extended	extended	JJ
en-wikipedia-org-4107	2183	9	release	release	NN
en-wikipedia-org-4107	2183	10	"	"	''
en-wikipedia-org-4107	2183	11	.	.	.
en-wikipedia-org-4107	2184	1	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	2184	2	.	.	.
en-wikipedia-org-4107	2185	1	Neos	Neos	NNP
en-wikipedia-org-4107	2185	2	Therapeutics	Therapeutics	NNP
en-wikipedia-org-4107	2185	3	,	,	,
en-wikipedia-org-4107	2185	4	Inc.	Inc.	NNP
en-wikipedia-org-4107	2185	5	8	8	CD
en-wikipedia-org-4107	2185	6	December	December	NNP
en-wikipedia-org-4107	2185	7	2017	2017	CD
en-wikipedia-org-4107	2185	8	.	.	.
en-wikipedia-org-4107	2186	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2186	2	25	25	CD
en-wikipedia-org-4107	2186	3	December	December	NNP
en-wikipedia-org-4107	2186	4	2019	2019	CD
en-wikipedia-org-4107	2186	5	.	.	.
en-wikipedia-org-4107	2187	1	^	^	FW
en-wikipedia-org-4107	2187	2	"	"	``
en-wikipedia-org-4107	2187	3	Drug	Drug	NNP
en-wikipedia-org-4107	2187	4	Approval	Approval	NNP
en-wikipedia-org-4107	2187	5	Package	package	NN
en-wikipedia-org-4107	2187	6	:	:	:
en-wikipedia-org-4107	2187	7	Adzenys	Adzenys	NNP
en-wikipedia-org-4107	2187	8	XR	XR	NNP
en-wikipedia-org-4107	2187	9	-	-	HYPH
en-wikipedia-org-4107	2187	10	ODT	ODT	NNP
en-wikipedia-org-4107	2187	11	(	(	-LRB-
en-wikipedia-org-4107	2187	12	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2187	13	)	)	-RRB-
en-wikipedia-org-4107	2187	14	"	"	''
en-wikipedia-org-4107	2187	15	.	.	.
en-wikipedia-org-4107	2188	1	United	United	NNP
en-wikipedia-org-4107	2188	2	States	States	NNP
en-wikipedia-org-4107	2188	3	Food	Food	NNP
en-wikipedia-org-4107	2188	4	and	and	CC
en-wikipedia-org-4107	2188	5	Drug	Drug	NNP
en-wikipedia-org-4107	2188	6	Administration	Administration	NNP
en-wikipedia-org-4107	2188	7	.	.	.
en-wikipedia-org-4107	2189	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2189	2	22	22	CD
en-wikipedia-org-4107	2189	3	December	December	NNP
en-wikipedia-org-4107	2189	4	2019	2019	CD
en-wikipedia-org-4107	2189	5	.	.	.
en-wikipedia-org-4107	2190	1	^	^	FW
en-wikipedia-org-4107	2190	2	"	"	``
en-wikipedia-org-4107	2190	3	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	2190	4	"	"	''
en-wikipedia-org-4107	2190	5	.	.	.
en-wikipedia-org-4107	2191	1	United	United	NNP
en-wikipedia-org-4107	2191	2	States	States	NNP
en-wikipedia-org-4107	2191	3	Food	Food	NNP
en-wikipedia-org-4107	2191	4	and	and	CC
en-wikipedia-org-4107	2191	5	Drug	Drug	NNP
en-wikipedia-org-4107	2191	6	Administration	Administration	NNP
en-wikipedia-org-4107	2191	7	.	.	.
en-wikipedia-org-4107	2192	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2192	2	11	11	CD
en-wikipedia-org-4107	2192	3	August	August	NNP
en-wikipedia-org-4107	2192	4	2015	2015	CD
en-wikipedia-org-4107	2192	5	.	.	.
en-wikipedia-org-4107	2193	1	^	^	FW
en-wikipedia-org-4107	2193	2	"	"	``
en-wikipedia-org-4107	2193	3	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	2193	4	ODT-	ODT-	NNP
en-wikipedia-org-4107	2193	5	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2193	6	sulfate	sulfate	NN
en-wikipedia-org-4107	2193	7	tablet	tablet	NN
en-wikipedia-org-4107	2193	8	,	,	,
en-wikipedia-org-4107	2193	9	orally	orally	RB
en-wikipedia-org-4107	2193	10	disintegrating	disintegrate	VBG
en-wikipedia-org-4107	2193	11	"	"	''
en-wikipedia-org-4107	2193	12	.	.	.
en-wikipedia-org-4107	2194	1	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	2194	2	.	.	.
en-wikipedia-org-4107	2195	1	Arbor	Arbor	NNP
en-wikipedia-org-4107	2195	2	Pharmaceuticals	Pharmaceuticals	NNPS
en-wikipedia-org-4107	2195	3	,	,	,
en-wikipedia-org-4107	2195	4	LLC	LLC	NNP
en-wikipedia-org-4107	2195	5	.	.	.
en-wikipedia-org-4107	2196	1	7	7	CD
en-wikipedia-org-4107	2196	2	June	June	NNP
en-wikipedia-org-4107	2196	3	2019	2019	CD
en-wikipedia-org-4107	2196	4	.	.	.
en-wikipedia-org-4107	2197	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2197	2	25	25	CD
en-wikipedia-org-4107	2197	3	December	December	NNP
en-wikipedia-org-4107	2197	4	2019	2019	CD
en-wikipedia-org-4107	2197	5	.	.	.
en-wikipedia-org-4107	2198	1	^	^	FW
en-wikipedia-org-4107	2198	2	"	"	``
en-wikipedia-org-4107	2198	3	Zenzedi-	Zenzedi-	NNP
en-wikipedia-org-4107	2198	4	dextroamphetamine	dextroamphetamine	NN
en-wikipedia-org-4107	2198	5	sulfate	sulfate	NN
en-wikipedia-org-4107	2198	6	tablet	tablet	NN
en-wikipedia-org-4107	2198	7	"	"	''
en-wikipedia-org-4107	2198	8	.	.	.
en-wikipedia-org-4107	2199	1	DailyMed	DailyMed	NNP
en-wikipedia-org-4107	2199	2	.	.	.
en-wikipedia-org-4107	2200	1	Arbor	Arbor	NNP
en-wikipedia-org-4107	2200	2	Pharmaceuticals	Pharmaceuticals	NNPS
en-wikipedia-org-4107	2200	3	,	,	,
en-wikipedia-org-4107	2200	4	LLC	LLC	NNP
en-wikipedia-org-4107	2200	5	.	.	.
en-wikipedia-org-4107	2201	1	14	14	CD
en-wikipedia-org-4107	2201	2	August	August	NNP
en-wikipedia-org-4107	2201	3	2019	2019	CD
en-wikipedia-org-4107	2201	4	.	.	.
en-wikipedia-org-4107	2202	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2202	2	22	22	CD
en-wikipedia-org-4107	2202	3	December	December	NNP
en-wikipedia-org-4107	2202	4	2019	2019	CD
en-wikipedia-org-4107	2202	5	.	.	.
en-wikipedia-org-4107	2203	1	^	^	FW
en-wikipedia-org-4107	2203	2	"	"	``
en-wikipedia-org-4107	2203	3	Drug	Drug	NNP
en-wikipedia-org-4107	2203	4	Approval	Approval	NNP
en-wikipedia-org-4107	2203	5	Package	Package	NNP
en-wikipedia-org-4107	2203	6	:	:	:
en-wikipedia-org-4107	2203	7	Vyvanse	vyvanse	NN
en-wikipedia-org-4107	2203	8	(	(	-LRB-
en-wikipedia-org-4107	2203	9	Lisdexamfetamine	Lisdexamfetamine	NNP
en-wikipedia-org-4107	2203	10	Dimesylate	Dimesylate	NNP
en-wikipedia-org-4107	2203	11	)	)	-RRB-
en-wikipedia-org-4107	2203	12	NDA	NDA	NNP
en-wikipedia-org-4107	2203	13	#	#	$
en-wikipedia-org-4107	2203	14	021977	021977	CD
en-wikipedia-org-4107	2203	15	"	"	''
en-wikipedia-org-4107	2203	16	.	.	.
en-wikipedia-org-4107	2204	1	United	United	NNP
en-wikipedia-org-4107	2204	2	States	States	NNP
en-wikipedia-org-4107	2204	3	Food	Food	NNP
en-wikipedia-org-4107	2204	4	and	and	CC
en-wikipedia-org-4107	2204	5	Drug	Drug	NNP
en-wikipedia-org-4107	2204	6	Administration	Administration	NNP
en-wikipedia-org-4107	2204	7	.	.	.
en-wikipedia-org-4107	2205	1	24	24	CD
en-wikipedia-org-4107	2205	2	December	December	NNP
en-wikipedia-org-4107	2205	3	1999	1999	CD
en-wikipedia-org-4107	2205	4	.	.	.
en-wikipedia-org-4107	2206	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2206	2	22	22	CD
en-wikipedia-org-4107	2206	3	December	December	NNP
en-wikipedia-org-4107	2206	4	2019	2019	CD
en-wikipedia-org-4107	2206	5	.	.	.
en-wikipedia-org-4107	2207	1	^	^	NNP
en-wikipedia-org-4107	2207	2	"	"	``
en-wikipedia-org-4107	2207	3	Molecular	Molecular	NNP
en-wikipedia-org-4107	2207	4	Weight	Weight	NNP
en-wikipedia-org-4107	2207	5	Calculator	Calculator	NNP
en-wikipedia-org-4107	2207	6	"	"	''
en-wikipedia-org-4107	2207	7	.	.	.
en-wikipedia-org-4107	2208	1	Lenntech	lenntech	NN
en-wikipedia-org-4107	2208	2	.	.	.
en-wikipedia-org-4107	2209	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2209	2	19	19	CD
en-wikipedia-org-4107	2209	3	August	August	NNP
en-wikipedia-org-4107	2209	4	2015	2015	CD
en-wikipedia-org-4107	2209	5	.	.	.
en-wikipedia-org-4107	2210	1	^	^	NNP
en-wikipedia-org-4107	2210	2	a	a	DT
en-wikipedia-org-4107	2210	3	b	b	NN
en-wikipedia-org-4107	2210	4	"	"	``
en-wikipedia-org-4107	2210	5	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	2210	6	Sulfate	Sulfate	NNP
en-wikipedia-org-4107	2210	7	USP	USP	NNP
en-wikipedia-org-4107	2210	8	"	"	''
en-wikipedia-org-4107	2210	9	.	.	.
en-wikipedia-org-4107	2211	1	Mallinckrodt	Mallinckrodt	NNP
en-wikipedia-org-4107	2211	2	Pharmaceuticals	Pharmaceuticals	NNP
en-wikipedia-org-4107	2211	3	.	.	.
en-wikipedia-org-4107	2212	1	March	March	NNP
en-wikipedia-org-4107	2212	2	2014	2014	CD
en-wikipedia-org-4107	2212	3	.	.	.
en-wikipedia-org-4107	2213	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2213	2	19	19	CD
en-wikipedia-org-4107	2213	3	August	August	NNP
en-wikipedia-org-4107	2213	4	2015	2015	CD
en-wikipedia-org-4107	2213	5	.	.	.
en-wikipedia-org-4107	2214	1	^	^	NNP
en-wikipedia-org-4107	2214	2	a	a	DT
en-wikipedia-org-4107	2214	3	b	b	NN
en-wikipedia-org-4107	2214	4	"	"	``
en-wikipedia-org-4107	2214	5	D	D	NNP
en-wikipedia-org-4107	2214	6	-	-	HYPH
en-wikipedia-org-4107	2214	7	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2214	8	sulfate	sulfate	NN
en-wikipedia-org-4107	2214	9	"	"	''
en-wikipedia-org-4107	2214	10	.	.	.
en-wikipedia-org-4107	2215	1	Tocris	Tocris	NNP
en-wikipedia-org-4107	2215	2	.	.	.
en-wikipedia-org-4107	2216	1	2015	2015	CD
en-wikipedia-org-4107	2216	2	.	.	.
en-wikipedia-org-4107	2217	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2217	2	19	19	CD
en-wikipedia-org-4107	2217	3	August	August	NNP
en-wikipedia-org-4107	2217	4	2015	2015	CD
en-wikipedia-org-4107	2217	5	.	.	.
en-wikipedia-org-4107	2218	1	^	^	NNP
en-wikipedia-org-4107	2218	2	a	a	DT
en-wikipedia-org-4107	2218	3	b	b	NNP
en-wikipedia-org-4107	2218	4	"	"	``
en-wikipedia-org-4107	2218	5	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2218	6	Sulfate	Sulfate	NNP
en-wikipedia-org-4107	2218	7	USP	USP	NNP
en-wikipedia-org-4107	2218	8	"	"	''
en-wikipedia-org-4107	2218	9	.	.	.
en-wikipedia-org-4107	2219	1	Mallinckrodt	Mallinckrodt	NNP
en-wikipedia-org-4107	2219	2	Pharmaceuticals	Pharmaceuticals	NNP
en-wikipedia-org-4107	2219	3	.	.	.
en-wikipedia-org-4107	2220	1	March	March	NNP
en-wikipedia-org-4107	2220	2	2014	2014	CD
en-wikipedia-org-4107	2220	3	.	.	.
en-wikipedia-org-4107	2221	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2221	2	19	19	CD
en-wikipedia-org-4107	2221	3	August	August	NNP
en-wikipedia-org-4107	2221	4	2015	2015	CD
en-wikipedia-org-4107	2221	5	.	.	.
en-wikipedia-org-4107	2222	1	^	^	FW
en-wikipedia-org-4107	2222	2	"	"	``
en-wikipedia-org-4107	2222	3	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	2222	4	Saccharate	Saccharate	NNP
en-wikipedia-org-4107	2222	5	"	"	''
en-wikipedia-org-4107	2222	6	.	.	.
en-wikipedia-org-4107	2223	1	Mallinckrodt	Mallinckrodt	NNP
en-wikipedia-org-4107	2223	2	Pharmaceuticals	Pharmaceuticals	NNP
en-wikipedia-org-4107	2223	3	.	.	.
en-wikipedia-org-4107	2224	1	March	March	NNP
en-wikipedia-org-4107	2224	2	2014	2014	CD
en-wikipedia-org-4107	2224	3	.	.	.
en-wikipedia-org-4107	2225	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2225	2	19	19	CD
en-wikipedia-org-4107	2225	3	August	August	NNP
en-wikipedia-org-4107	2225	4	2015	2015	CD
en-wikipedia-org-4107	2225	5	.	.	.
en-wikipedia-org-4107	2226	1	^	^	FW
en-wikipedia-org-4107	2226	2	"	"	``
en-wikipedia-org-4107	2226	3	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2226	4	Aspartate	Aspartate	NNP
en-wikipedia-org-4107	2226	5	"	"	''
en-wikipedia-org-4107	2226	6	.	.	.
en-wikipedia-org-4107	2227	1	Mallinckrodt	Mallinckrodt	NNP
en-wikipedia-org-4107	2227	2	Pharmaceuticals	Pharmaceuticals	NNP
en-wikipedia-org-4107	2227	3	.	.	.
en-wikipedia-org-4107	2228	1	March	March	NNP
en-wikipedia-org-4107	2228	2	2014	2014	CD
en-wikipedia-org-4107	2228	3	.	.	.
en-wikipedia-org-4107	2229	1	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2229	2	19	19	CD
en-wikipedia-org-4107	2229	3	August	August	NNP
en-wikipedia-org-4107	2229	4	2015	2015	CD
en-wikipedia-org-4107	2229	5	.	.	.
en-wikipedia-org-4107	2230	1	External	external	JJ
en-wikipedia-org-4107	2230	2	links	link	NNS
en-wikipedia-org-4107	2230	3	"	"	``
en-wikipedia-org-4107	2230	4	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2230	5	"	"	''
en-wikipedia-org-4107	2230	6	.	.	.
en-wikipedia-org-4107	2231	1	Drug	Drug	NNP
en-wikipedia-org-4107	2231	2	Information	Information	NNP
en-wikipedia-org-4107	2231	3	Portal	Portal	NNP
en-wikipedia-org-4107	2231	4	.	.	.
en-wikipedia-org-4107	2232	1	United	United	NNP
en-wikipedia-org-4107	2232	2	States	States	NNP
en-wikipedia-org-4107	2232	3	National	National	NNP
en-wikipedia-org-4107	2232	4	Library	Library	NNP
en-wikipedia-org-4107	2232	5	of	of	IN
en-wikipedia-org-4107	2232	6	Medicine	Medicine	NNP
en-wikipedia-org-4107	2232	7	.	.	.
en-wikipedia-org-4107	2233	1	CID	CID	NNP
en-wikipedia-org-4107	2233	2	5826	5826	CD
en-wikipedia-org-4107	2233	3	from	from	IN
en-wikipedia-org-4107	2233	4	PubChem	PubChem	NNP
en-wikipedia-org-4107	2233	5	 	  	_SP
en-wikipedia-org-4107	2233	6	–	–	:
en-wikipedia-org-4107	2233	7	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	2233	8	CID	CID	NNP
en-wikipedia-org-4107	2233	9	32893	32893	CD
en-wikipedia-org-4107	2233	10	from	from	IN
en-wikipedia-org-4107	2233	11	PubChem	PubChem	NNP
en-wikipedia-org-4107	2233	12	 	  	_SP
en-wikipedia-org-4107	2233	13	–	–	:
en-wikipedia-org-4107	2233	14	Levoamphetamine	Levoamphetamine	NNP
en-wikipedia-org-4107	2233	15	Comparative	Comparative	NNP
en-wikipedia-org-4107	2233	16	Toxicogenomics	Toxicogenomics	NNPS
en-wikipedia-org-4107	2233	17	Database	Database	NNP
en-wikipedia-org-4107	2233	18	entry	entry	NN
en-wikipedia-org-4107	2233	19	:	:	:
en-wikipedia-org-4107	2233	20	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2233	21	Comparative	Comparative	NNP
en-wikipedia-org-4107	2233	22	Toxicogenomics	Toxicogenomics	NNPS
en-wikipedia-org-4107	2233	23	Database	Database	NNP
en-wikipedia-org-4107	2233	24	entry	entry	NN
en-wikipedia-org-4107	2233	25	:	:	:
en-wikipedia-org-4107	2233	26	CARTPT	CARTPT	NNP
en-wikipedia-org-4107	2233	27	v	v	NN
en-wikipedia-org-4107	2233	28	t	t	NN
en-wikipedia-org-4107	2233	29	e	e	NN
en-wikipedia-org-4107	2233	30	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2233	31	Main	Main	NNP
en-wikipedia-org-4107	2233	32	articles	article	NNS
en-wikipedia-org-4107	2233	33	and	and	CC
en-wikipedia-org-4107	2233	34	pharmaceuticals	pharmaceutical	NNS
en-wikipedia-org-4107	2233	35	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2233	36	Adzenys	Adzenys	NNP
en-wikipedia-org-4107	2233	37	 	  	_SP
en-wikipedia-org-4107	2233	38	ER	ER	NNP
en-wikipedia-org-4107	2233	39	Adzenys	Adzenys	NNP
en-wikipedia-org-4107	2233	40	XR	XR	NNP
en-wikipedia-org-4107	2233	41	-	-	HYPH
en-wikipedia-org-4107	2233	42	ODT	ODT	NNP
en-wikipedia-org-4107	2233	43	Dyanavel	Dyanavel	NNP
en-wikipedia-org-4107	2233	44	 	  	_SP
en-wikipedia-org-4107	2233	45	XR	XR	NNP
en-wikipedia-org-4107	2233	46	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	2233	47	Evekeo	Evekeo	NNP
en-wikipedia-org-4107	2233	48	 	  	_SP
en-wikipedia-org-4107	2233	49	ODT	ODT	NNP
en-wikipedia-org-4107	2233	50	Mixed	mix	VBN
en-wikipedia-org-4107	2233	51	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2233	52	salts	salt	VBZ
en-wikipedia-org-4107	2233	53	Adderall	Adderall	NNP
en-wikipedia-org-4107	2233	54	Adderall	Adderall	NNP
en-wikipedia-org-4107	2233	55	 	  	_SP
en-wikipedia-org-4107	2233	56	XR	XR	NNP
en-wikipedia-org-4107	2233	57	Mydayis	Mydayis	NNP
en-wikipedia-org-4107	2233	58	Levoamphetamine	Levoamphetamine	NNP
en-wikipedia-org-4107	2233	59	N	N	NNP
en-wikipedia-org-4107	2233	60	/	/	SYM
en-wikipedia-org-4107	2233	61	A	A	NNP
en-wikipedia-org-4107	2233	62	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	2233	63	Dexedrine	Dexedrine	NNP
en-wikipedia-org-4107	2233	64	ProCentra	ProCentra	NNP
en-wikipedia-org-4107	2233	65	Zenzedi	Zenzedi	NNP
en-wikipedia-org-4107	2233	66	Lisdexamfetamine	Lisdexamfetamine	NNP
en-wikipedia-org-4107	2233	67	Vyvanse	Vyvanse	NNP
en-wikipedia-org-4107	2233	68	Neuropharmacology	Neuropharmacology	NNP
en-wikipedia-org-4107	2233	69	Biomolecular	Biomolecular	NNP
en-wikipedia-org-4107	2233	70	targets	target	NNS
en-wikipedia-org-4107	2233	71	TAAR1	taar1	NN
en-wikipedia-org-4107	2233	72	(	(	-LRB-
en-wikipedia-org-4107	2233	73	full	full	JJ
en-wikipedia-org-4107	2233	74	agonist	agonist	NN
en-wikipedia-org-4107	2233	75	)	)	-RRB-
en-wikipedia-org-4107	2233	76	CART	CART	NNP
en-wikipedia-org-4107	2233	77	(	(	-LRB-
en-wikipedia-org-4107	2233	78	mRNA	mRNA	NNP
en-wikipedia-org-4107	2233	79	inducer	inducer	NNP
en-wikipedia-org-4107	2233	80	)	)	-RRB-
en-wikipedia-org-4107	2233	81	5-HT1A	5-HT1A	NNP
en-wikipedia-org-4107	2233	82	receptor	receptor	NN
en-wikipedia-org-4107	2233	83	(	(	-LRB-
en-wikipedia-org-4107	2233	84	low	low	JJ
en-wikipedia-org-4107	2233	85	affinity	affinity	NN
en-wikipedia-org-4107	2233	86	ligand	ligand	NN
en-wikipedia-org-4107	2233	87	)	)	-RRB-
en-wikipedia-org-4107	2233	88	MAO	MAO	NNP
en-wikipedia-org-4107	2233	89	(	(	-LRB-
en-wikipedia-org-4107	2233	90	weak	weak	JJ
en-wikipedia-org-4107	2233	91	competitive	competitive	JJ
en-wikipedia-org-4107	2233	92	inhibitor	inhibitor	NN
en-wikipedia-org-4107	2233	93	)	)	-RRB-
en-wikipedia-org-4107	2233	94	Carbonic	Carbonic	NNP
en-wikipedia-org-4107	2233	95	anhydrases	anhydrase	VBZ
en-wikipedia-org-4107	2233	96	hCA4	hCA4	NNP
en-wikipedia-org-4107	2233	97	,	,	,
en-wikipedia-org-4107	2233	98	hCA5A	hCA5A	NNP
en-wikipedia-org-4107	2233	99	,	,	,
en-wikipedia-org-4107	2233	100	hCA5B	hca5b	NN
en-wikipedia-org-4107	2233	101	,	,	,
en-wikipedia-org-4107	2233	102	hCA7	hCA7	NNP
en-wikipedia-org-4107	2233	103	,	,	,
en-wikipedia-org-4107	2233	104	hCA12	hCA12	NNP
en-wikipedia-org-4107	2233	105	,	,	,
en-wikipedia-org-4107	2233	106	hCA13	hCA13	NNP
en-wikipedia-org-4107	2233	107	,	,	,
en-wikipedia-org-4107	2233	108	and	and	CC
en-wikipedia-org-4107	2233	109	hCA14	hCA14	NNP
en-wikipedia-org-4107	2233	110	(	(	-LRB-
en-wikipedia-org-4107	2233	111	enzyme	enzyme	NNS
en-wikipedia-org-4107	2233	112	activator	activator	NN
en-wikipedia-org-4107	2233	113	)	)	-RRB-
en-wikipedia-org-4107	2233	114	Inhibited	inhibited	JJ
en-wikipedia-org-4107	2233	115	transporters	transporter	NNS
en-wikipedia-org-4107	2233	116	DAT	DAT	NNP
en-wikipedia-org-4107	2233	117	NET	NET	NNP
en-wikipedia-org-4107	2233	118	SERT	SERT	NNP
en-wikipedia-org-4107	2233	119	VMAT1	VMAT1	NNP
en-wikipedia-org-4107	2233	120	VMAT2	vmat2	FW
en-wikipedia-org-4107	2233	121	EAAT3	eaat3	UH
en-wikipedia-org-4107	2233	122	SLC22A3	slc22a3	NN
en-wikipedia-org-4107	2233	123	SLC22A5	SLC22A5	NNP
en-wikipedia-org-4107	2233	124	Active	active	JJ
en-wikipedia-org-4107	2233	125	metabolites	metabolite	NNS
en-wikipedia-org-4107	2233	126	4-Hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	2233	127	4-Hydroxynorephedrine	4-hydroxynorephedrine	CD
en-wikipedia-org-4107	2233	128	Norephedrine	norephedrine	JJ
en-wikipedia-org-4107	2233	129	Related	related	JJ
en-wikipedia-org-4107	2233	130	articles	article	NNS
en-wikipedia-org-4107	2233	131	ADHD	ADHD	NNP
en-wikipedia-org-4107	2233	132	ADHD	ADHD	NNP
en-wikipedia-org-4107	2233	133	management	management	NN
en-wikipedia-org-4107	2233	134	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2233	135	psychosis	psychosis	NN
en-wikipedia-org-4107	2233	136	Benzedrine	benzedrine	NN
en-wikipedia-org-4107	2233	137	in	in	IN
en-wikipedia-org-4107	2233	138	popular	popular	JJ
en-wikipedia-org-4107	2233	139	culture	culture	NN
en-wikipedia-org-4107	2233	140	Dopamine	Dopamine	NNP
en-wikipedia-org-4107	2233	141	Doping	Doping	NNP
en-wikipedia-org-4107	2233	142	in	in	IN
en-wikipedia-org-4107	2233	143	sport	sport	NN
en-wikipedia-org-4107	2233	144	Executive	executive	JJ
en-wikipedia-org-4107	2233	145	functions	function	NNS
en-wikipedia-org-4107	2233	146	Formetorex	Formetorex	NNP
en-wikipedia-org-4107	2233	147	ΔFosB	ΔFosB	NNP
en-wikipedia-org-4107	2233	148	History	history	NN
en-wikipedia-org-4107	2233	149	and	and	CC
en-wikipedia-org-4107	2233	150	culture	culture	NN
en-wikipedia-org-4107	2233	151	of	of	IN
en-wikipedia-org-4107	2233	152	substituted	substitute	VBN
en-wikipedia-org-4107	2233	153	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	2233	154	Methamphetamine	Methamphetamine	NNP
en-wikipedia-org-4107	2233	155	Methylphenidate	Methylphenidate	NNP
en-wikipedia-org-4107	2233	156	N	N	NNP
en-wikipedia-org-4107	2233	157	-	-	HYPH
en-wikipedia-org-4107	2233	158	Methylphenethylamine	Methylphenethylamine	NNP
en-wikipedia-org-4107	2233	159	Motivational	Motivational	NNP
en-wikipedia-org-4107	2233	160	salience	salience	NN
en-wikipedia-org-4107	2233	161	Incentive	Incentive	NNP
en-wikipedia-org-4107	2233	162	salience	salience	NN
en-wikipedia-org-4107	2233	163	Narcolepsy	Narcolepsy	NNP
en-wikipedia-org-4107	2233	164	Neurobiological	neurobiological	JJ
en-wikipedia-org-4107	2233	165	effects	effect	NNS
en-wikipedia-org-4107	2233	166	of	of	IN
en-wikipedia-org-4107	2233	167	physical	physical	JJ
en-wikipedia-org-4107	2233	168	exercise	exercise	NN
en-wikipedia-org-4107	2233	169	§	§	ADD
en-wikipedia-org-4107	2233	170	 	  	_SP
en-wikipedia-org-4107	2233	171	Attention	attention	NN
en-wikipedia-org-4107	2233	172	deficit	deficit	NN
en-wikipedia-org-4107	2233	173	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	2233	174	disorder	disorder	NN
en-wikipedia-org-4107	2233	175	Nootropic	Nootropic	NNP
en-wikipedia-org-4107	2233	176	Norepinephrine	Norepinephrine	NNP
en-wikipedia-org-4107	2233	177	Obesity	Obesity	NNP
en-wikipedia-org-4107	2233	178	Performance	Performance	NNP
en-wikipedia-org-4107	2233	179	-	-	HYPH
en-wikipedia-org-4107	2233	180	enhancing	enhance	VBG
en-wikipedia-org-4107	2233	181	substance	substance	NN
en-wikipedia-org-4107	2233	182	Phenethylamine	Phenethylamine	NNP
en-wikipedia-org-4107	2233	183	Phentermine	Phentermine	NNP
en-wikipedia-org-4107	2233	184	Phenylacetone	Phenylacetone	NNP
en-wikipedia-org-4107	2233	185	Recreational	recreational	JJ
en-wikipedia-org-4107	2233	186	drug	drug	NN
en-wikipedia-org-4107	2233	187	use	use	NN
en-wikipedia-org-4107	2233	188	Serotonin	Serotonin	NNP
en-wikipedia-org-4107	2233	189	Substituted	Substituted	NNP
en-wikipedia-org-4107	2233	190	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2233	191	Trace	Trace	NNP
en-wikipedia-org-4107	2233	192	amine	amine	NN
en-wikipedia-org-4107	2233	193	Category	Category	NNP
en-wikipedia-org-4107	2233	194	v	v	NNP
en-wikipedia-org-4107	2233	195	t	t	NN
en-wikipedia-org-4107	2233	196	e	e	NN
en-wikipedia-org-4107	2233	197	ADHD	ADHD	NNP
en-wikipedia-org-4107	2233	198	pharmacotherapies	pharmacotherapie	NNS
en-wikipedia-org-4107	2233	199	CNS	CNS	NNP
en-wikipedia-org-4107	2233	200	stimulants	stimulant	NNS
en-wikipedia-org-4107	2233	201	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2233	202	(	(	-LRB-
en-wikipedia-org-4107	2233	203	Mixed	Mixed	NNP
en-wikipedia-org-4107	2233	204	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2233	205	salts	salt	NNS
en-wikipedia-org-4107	2233	206	,	,	,
en-wikipedia-org-4107	2233	207	Levoamphetamine	Levoamphetamine	NNP
en-wikipedia-org-4107	2233	208	,	,	,
en-wikipedia-org-4107	2233	209	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	2233	210	,	,	,
en-wikipedia-org-4107	2233	211	Lisdexamfetamine	Lisdexamfetamine	NNP
en-wikipedia-org-4107	2233	212	)	)	-RRB-
en-wikipedia-org-4107	2233	213	Methamphetamine	Methamphetamine	NNP
en-wikipedia-org-4107	2233	214	Methylphenidate	Methylphenidate	NNP
en-wikipedia-org-4107	2233	215	Dexmethylphenidate	dexmethylphenidate	NN
en-wikipedia-org-4107	2233	216	Serdexmethylphenidate	Serdexmethylphenidate	NNP
en-wikipedia-org-4107	2233	217	Non	non	JJ
en-wikipedia-org-4107	2233	218	-	-	JJ
en-wikipedia-org-4107	2233	219	classical	classical	JJ
en-wikipedia-org-4107	2233	220	CNS	cns	NN
en-wikipedia-org-4107	2233	221	stimulants	stimulant	NNS
en-wikipedia-org-4107	2233	222	Armodafinil	Armodafinil	NNP
en-wikipedia-org-4107	2233	223	Atomoxetine	Atomoxetine	NNP
en-wikipedia-org-4107	2233	224	Modafinil	Modafinil	NNP
en-wikipedia-org-4107	2233	225	α2-adrenoceptor	α2-adrenoceptor	NNP
en-wikipedia-org-4107	2233	226	agonists	agonist	VBZ
en-wikipedia-org-4107	2233	227	Clonidine	Clonidine	NNP
en-wikipedia-org-4107	2233	228	Guanfacine	Guanfacine	NNP
en-wikipedia-org-4107	2233	229	Antidepressants	Antidepressants	NNP
en-wikipedia-org-4107	2233	230	Amitriptyline	Amitriptyline	NNP
en-wikipedia-org-4107	2233	231	Bupropion	Bupropion	NNP
en-wikipedia-org-4107	2233	232	Buspirone	Buspirone	NNP
en-wikipedia-org-4107	2233	233	Desipramine	Desipramine	NNP
en-wikipedia-org-4107	2233	234	Duloxetine	Duloxetine	NNP
en-wikipedia-org-4107	2233	235	Imipramine	Imipramine	NNP
en-wikipedia-org-4107	2233	236	Milnacipran	Milnacipran	NNP
en-wikipedia-org-4107	2233	237	Moclobemide	Moclobemide	NNP
en-wikipedia-org-4107	2233	238	Nortriptyline	Nortriptyline	NNP
en-wikipedia-org-4107	2233	239	Reboxetine	Reboxetine	NNP
en-wikipedia-org-4107	2233	240	Venlafaxine	Venlafaxine	NNP
en-wikipedia-org-4107	2233	241	Miscellaneous	Miscellaneous	NNP
en-wikipedia-org-4107	2233	242	/	/	SYM
en-wikipedia-org-4107	2233	243	others	other	NNS
en-wikipedia-org-4107	2233	244	Amantadine	Amantadine	NNP
en-wikipedia-org-4107	2233	245	Carbamazepine	Carbamazepine	NNP
en-wikipedia-org-4107	2233	246	Related	related	JJ
en-wikipedia-org-4107	2233	247	articles	article	NNS
en-wikipedia-org-4107	2233	248	Attention	attention	NN
en-wikipedia-org-4107	2233	249	deficit	deficit	NN
en-wikipedia-org-4107	2233	250	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	2233	251	disorder	disorder	NN
en-wikipedia-org-4107	2233	252	(	(	-LRB-
en-wikipedia-org-4107	2233	253	ADHD	ADHD	NNP
en-wikipedia-org-4107	2233	254	)	)	-RRB-
en-wikipedia-org-4107	2233	255	Attention	attention	NN
en-wikipedia-org-4107	2233	256	deficit	deficit	NN
en-wikipedia-org-4107	2233	257	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	2233	258	disorder	disorder	NN
en-wikipedia-org-4107	2233	259	management	management	NN
en-wikipedia-org-4107	2233	260	Monoamine	Monoamine	NNP
en-wikipedia-org-4107	2233	261	releasing	release	VBG
en-wikipedia-org-4107	2233	262	agent	agent	NN
en-wikipedia-org-4107	2233	263	Dopamine	Dopamine	NNP
en-wikipedia-org-4107	2233	264	(	(	-LRB-
en-wikipedia-org-4107	2233	265	DA	DA	NNP
en-wikipedia-org-4107	2233	266	)	)	-RRB-
en-wikipedia-org-4107	2233	267	Dopamine	Dopamine	NNP
en-wikipedia-org-4107	2233	268	transporter	transporter	NN
en-wikipedia-org-4107	2233	269	(	(	-LRB-
en-wikipedia-org-4107	2233	270	DAT	DAT	NNP
en-wikipedia-org-4107	2233	271	)	)	-RRB-
en-wikipedia-org-4107	2233	272	Dopamine	Dopamine	NNP
en-wikipedia-org-4107	2233	273	reuptake	reuptake	NN
en-wikipedia-org-4107	2233	274	inhibitor	inhibitor	NN
en-wikipedia-org-4107	2233	275	(	(	-LRB-
en-wikipedia-org-4107	2233	276	DRI	dri	NN
en-wikipedia-org-4107	2233	277	)	)	-RRB-
en-wikipedia-org-4107	2233	278	Norepinephrine	Norepinephrine	NNP
en-wikipedia-org-4107	2233	279	(	(	-LRB-
en-wikipedia-org-4107	2233	280	NE	NE	NNP
en-wikipedia-org-4107	2233	281	)	)	-RRB-
en-wikipedia-org-4107	2233	282	Norepinephrine	Norepinephrine	NNP
en-wikipedia-org-4107	2233	283	transporter	transporter	NN
en-wikipedia-org-4107	2233	284	(	(	-LRB-
en-wikipedia-org-4107	2233	285	NET	NET	NNP
en-wikipedia-org-4107	2233	286	)	)	-RRB-
en-wikipedia-org-4107	2233	287	Norepinephrine	Norepinephrine	NNP
en-wikipedia-org-4107	2233	288	reuptake	reuptake	NN
en-wikipedia-org-4107	2233	289	inhibitor	inhibitor	NN
en-wikipedia-org-4107	2233	290	(	(	-LRB-
en-wikipedia-org-4107	2233	291	NRI	NRI	NNP
en-wikipedia-org-4107	2233	292	)	)	-RRB-
en-wikipedia-org-4107	2233	293	Serotonin	Serotonin	NNP
en-wikipedia-org-4107	2233	294	(	(	-LRB-
en-wikipedia-org-4107	2233	295	5-HT	5-ht	CD
en-wikipedia-org-4107	2233	296	)	)	-RRB-
en-wikipedia-org-4107	2233	297	Serotonin	serotonin	JJ
en-wikipedia-org-4107	2233	298	transporter	transporter	NN
en-wikipedia-org-4107	2233	299	(	(	-LRB-
en-wikipedia-org-4107	2233	300	SERT	SERT	NNP
en-wikipedia-org-4107	2233	301	)	)	-RRB-
en-wikipedia-org-4107	2233	302	Selective	Selective	NNP
en-wikipedia-org-4107	2233	303	serotonin	serotonin	NN
en-wikipedia-org-4107	2233	304	reuptake	reuptake	NN
en-wikipedia-org-4107	2233	305	inhibitor	inhibitor	NN
en-wikipedia-org-4107	2233	306	(	(	-LRB-
en-wikipedia-org-4107	2233	307	SSRI	SSRI	NNP
en-wikipedia-org-4107	2233	308	)	)	-RRB-
en-wikipedia-org-4107	2233	309	Serotonin	Serotonin	NNP
en-wikipedia-org-4107	2233	310	-	-	HYPH
en-wikipedia-org-4107	2233	311	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	2233	312	reuptake	reuptake	NN
en-wikipedia-org-4107	2233	313	inhibitor	inhibitor	NN
en-wikipedia-org-4107	2233	314	(	(	-LRB-
en-wikipedia-org-4107	2233	315	SNRI	SNRI	NNP
en-wikipedia-org-4107	2233	316	)	)	-RRB-
en-wikipedia-org-4107	2233	317	Norepinephrine	Norepinephrine	NNP
en-wikipedia-org-4107	2233	318	-	-	HYPH
en-wikipedia-org-4107	2233	319	dopamine	dopamine	NN
en-wikipedia-org-4107	2233	320	reuptake	reuptake	NN
en-wikipedia-org-4107	2233	321	inhibitor	inhibitor	NN
en-wikipedia-org-4107	2233	322	(	(	-LRB-
en-wikipedia-org-4107	2233	323	NDRI	NDRI	NNP
en-wikipedia-org-4107	2233	324	)	)	-RRB-
en-wikipedia-org-4107	2233	325	Serotonin	Serotonin	NNP
en-wikipedia-org-4107	2233	326	-	-	HYPH
en-wikipedia-org-4107	2233	327	norepinephrine	norepinephrine	NN
en-wikipedia-org-4107	2233	328	-	-	HYPH
en-wikipedia-org-4107	2233	329	dopamine	dopamine	NN
en-wikipedia-org-4107	2233	330	reuptake	reuptake	NN
en-wikipedia-org-4107	2233	331	inhibitor	inhibitor	NN
en-wikipedia-org-4107	2233	332	(	(	-LRB-
en-wikipedia-org-4107	2233	333	SNDRI	SNDRI	NNP
en-wikipedia-org-4107	2233	334	)	)	-RRB-
en-wikipedia-org-4107	2233	335	v	v	NNP
en-wikipedia-org-4107	2233	336	t	t	NN
en-wikipedia-org-4107	2233	337	e	e	NNP
en-wikipedia-org-4107	2233	338	Human	Human	NNP
en-wikipedia-org-4107	2233	339	trace	trace	NN
en-wikipedia-org-4107	2233	340	amine	amine	NN
en-wikipedia-org-4107	2233	341	-	-	HYPH
en-wikipedia-org-4107	2233	342	associated	associate	VBN
en-wikipedia-org-4107	2233	343	receptor	receptor	NN
en-wikipedia-org-4107	2233	344	ligands	ligand	VBZ
en-wikipedia-org-4107	2233	345	TAAR1	taar1	NN
en-wikipedia-org-4107	2233	346	Agonists	agonist	NNS
en-wikipedia-org-4107	2233	347	Endogenous†	endogenous†	CD
en-wikipedia-org-4107	2233	348	Classical	classical	JJ
en-wikipedia-org-4107	2233	349	monoamine	monoamine	NN
en-wikipedia-org-4107	2233	350	neurotransmitters	neurotransmitter	NNS
en-wikipedia-org-4107	2233	351	Dopamine	Dopamine	NNP
en-wikipedia-org-4107	2233	352	Histamine	Histamine	NNP
en-wikipedia-org-4107	2233	353	Norepinephrine	Norepinephrine	NNP
en-wikipedia-org-4107	2233	354	Serotonin	Serotonin	NNP
en-wikipedia-org-4107	2233	355	Trace	Trace	NNP
en-wikipedia-org-4107	2233	356	amines	amine	VBZ
en-wikipedia-org-4107	2233	357	3-Iodothyronamine	3-iodothyronamine	CD
en-wikipedia-org-4107	2233	358	3-Methoxytyramine	3-methoxytyramine	CD
en-wikipedia-org-4107	2233	359	N	N	NNP
en-wikipedia-org-4107	2233	360	-	-	HYPH
en-wikipedia-org-4107	2233	361	Methylphenethylamine	Methylphenethylamine	NNP
en-wikipedia-org-4107	2233	362	N	N	NNP
en-wikipedia-org-4107	2233	363	-	-	HYPH
en-wikipedia-org-4107	2233	364	Methyltyramine	Methyltyramine	NNP
en-wikipedia-org-4107	2233	365	m	m	NNP
en-wikipedia-org-4107	2233	366	-	-	HYPH
en-wikipedia-org-4107	2233	367	Octopamine	Octopamine	NNP
en-wikipedia-org-4107	2233	368	p	p	NNP
en-wikipedia-org-4107	2233	369	-	-	HYPH
en-wikipedia-org-4107	2233	370	Octopamine	Octopamine	NNP
en-wikipedia-org-4107	2233	371	Phenethylamine	Phenethylamine	NNP
en-wikipedia-org-4107	2233	372	Phenylethanolamine	Phenylethanolamine	NNP
en-wikipedia-org-4107	2233	373	Synephrine	Synephrine	NNP
en-wikipedia-org-4107	2233	374	Tryptamine	Tryptamine	NNP
en-wikipedia-org-4107	2233	375	m	m	NNP
en-wikipedia-org-4107	2233	376	-	-	:
en-wikipedia-org-4107	2233	377	Tyramine	Tyramine	NNP
en-wikipedia-org-4107	2233	378	p	p	NNP
en-wikipedia-org-4107	2233	379	-	-	:
en-wikipedia-org-4107	2233	380	Tyramine	Tyramine	NNP
en-wikipedia-org-4107	2233	381	Synthetic‡	Synthetic‡	NNP
en-wikipedia-org-4107	2233	382	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2233	383	DOB	DOB	NNP
en-wikipedia-org-4107	2233	384	DOET	DOET	NNP
en-wikipedia-org-4107	2233	385	4-Hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	2233	386	Isoprenaline	Isoprenaline	NNP
en-wikipedia-org-4107	2233	387	MDA	MDA	NNP
en-wikipedia-org-4107	2233	388	(	(	-LRB-
en-wikipedia-org-4107	2233	389	tenamfetamine	tenamfetamine	NN
en-wikipedia-org-4107	2233	390	)	)	-RRB-
en-wikipedia-org-4107	2233	391	MDMA	MDMA	NNP
en-wikipedia-org-4107	2233	392	(	(	-LRB-
en-wikipedia-org-4107	2233	393	midomafetamine	midomafetamine	NN
en-wikipedia-org-4107	2233	394	)	)	-RRB-
en-wikipedia-org-4107	2233	395	2-Methylphenethylamine	2-methylphenethylamine	CD
en-wikipedia-org-4107	2233	396	3-Methylphenethylamine	3-methylphenethylamine	CD
en-wikipedia-org-4107	2233	397	4-Methylphenethylamine	4-methylphenethylamine	CD
en-wikipedia-org-4107	2233	398	β	β	NNP
en-wikipedia-org-4107	2233	399	-	-	HYPH
en-wikipedia-org-4107	2233	400	Methylphenethylamine	Methylphenethylamine	NNP
en-wikipedia-org-4107	2233	401	Methamphetamine	Methamphetamine	NNP
en-wikipedia-org-4107	2233	402	3-MMA	3-MMA	NNP
en-wikipedia-org-4107	2233	403	Norfenfluramine	Norfenfluramine	NNP
en-wikipedia-org-4107	2233	404	Phentermine	phentermine	JJ
en-wikipedia-org-4107	2233	405	o	o	NNP
en-wikipedia-org-4107	2233	406	-	-	HYPH
en-wikipedia-org-4107	2233	407	PIT	PIT	NNP
en-wikipedia-org-4107	2233	408	Propylhexedrine	Propylhexedrine	NNP
en-wikipedia-org-4107	2233	409	RO5166017	RO5166017	NNP
en-wikipedia-org-4107	2233	410	N	N	NNP
en-wikipedia-org-4107	2233	411	,	,	,
en-wikipedia-org-4107	2233	412	N	N	NNP
en-wikipedia-org-4107	2233	413	-	-	HYPH
en-wikipedia-org-4107	2233	414	Dimethylphenethylamine	Dimethylphenethylamine	NNP
en-wikipedia-org-4107	2233	415	Neutral	neutral	JJ
en-wikipedia-org-4107	2233	416	antagonists	antagonist	NNS
en-wikipedia-org-4107	2233	417	  	  	_SP
en-wikipedia-org-4107	2233	418	Inverse	Inverse	NNP
en-wikipedia-org-4107	2233	419	agonists	agonist	NNS
en-wikipedia-org-4107	2233	420	EPPTB	EPPTB	NNP
en-wikipedia-org-4107	2233	421	(	(	-LRB-
en-wikipedia-org-4107	2233	422	RO5212773	RO5212773	NNP
en-wikipedia-org-4107	2233	423	)	)	-RRB-
en-wikipedia-org-4107	2233	424	TAAR2	taar2	NN
en-wikipedia-org-4107	2233	425	Agonists‡	agonists‡	LS
en-wikipedia-org-4107	2233	426	  	  	_SP
en-wikipedia-org-4107	2233	427	Neutral	Neutral	NNP
en-wikipedia-org-4107	2233	428	antagonists	antagonist	NNS
en-wikipedia-org-4107	2233	429	  	  	_SP
en-wikipedia-org-4107	2233	430	TAAR5	taar5	NN
en-wikipedia-org-4107	2233	431	Agonists‡	Agonists‡	NNP
en-wikipedia-org-4107	2233	432	N	N	NNP
en-wikipedia-org-4107	2233	433	,	,	,
en-wikipedia-org-4107	2233	434	N	N	NNP
en-wikipedia-org-4107	2233	435	-	-	HYPH
en-wikipedia-org-4107	2233	436	Dimethylethylamine	Dimethylethylamine	NNP
en-wikipedia-org-4107	2233	437	Trimethylamine	Trimethylamine	NNP
en-wikipedia-org-4107	2233	438	Neutral	neutral	JJ
en-wikipedia-org-4107	2233	439	antagonists	antagonist	NNS
en-wikipedia-org-4107	2233	440	  	  	_SP
en-wikipedia-org-4107	2233	441	Inverse	Inverse	NNP
en-wikipedia-org-4107	2233	442	agonists‡	agonists‡	NNP
en-wikipedia-org-4107	2233	443	3-Iodothyronamine	3-iodothyronamine	CD
en-wikipedia-org-4107	2233	444	†	†	JJ
en-wikipedia-org-4107	2233	445	References	reference	NNS
en-wikipedia-org-4107	2233	446	for	for	IN
en-wikipedia-org-4107	2233	447	all	all	DT
en-wikipedia-org-4107	2233	448	endogenous	endogenous	JJ
en-wikipedia-org-4107	2233	449	human	human	JJ
en-wikipedia-org-4107	2233	450	TAAR1	taar1	NN
en-wikipedia-org-4107	2233	451	ligands	ligand	NNS
en-wikipedia-org-4107	2233	452	are	be	VBP
en-wikipedia-org-4107	2233	453	provided	provide	VBN
en-wikipedia-org-4107	2233	454	at	at	IN
en-wikipedia-org-4107	2233	455	List	list	NN
en-wikipedia-org-4107	2233	456	of	of	IN
en-wikipedia-org-4107	2233	457	trace	trace	NN
en-wikipedia-org-4107	2233	458	amines	amine	NNS
en-wikipedia-org-4107	2233	459	‡	‡	IN
en-wikipedia-org-4107	2233	460	References	reference	NNS
en-wikipedia-org-4107	2233	461	for	for	IN
en-wikipedia-org-4107	2233	462	synthetic	synthetic	JJ
en-wikipedia-org-4107	2233	463	TAAR1	taar1	NN
en-wikipedia-org-4107	2233	464	agonists	agonist	NNS
en-wikipedia-org-4107	2233	465	can	can	MD
en-wikipedia-org-4107	2233	466	be	be	VB
en-wikipedia-org-4107	2233	467	found	find	VBN
en-wikipedia-org-4107	2233	468	at	at	IN
en-wikipedia-org-4107	2233	469	TAAR1	taar1	NN
en-wikipedia-org-4107	2233	470	or	or	CC
en-wikipedia-org-4107	2233	471	in	in	IN
en-wikipedia-org-4107	2233	472	the	the	DT
en-wikipedia-org-4107	2233	473	associated	associated	JJ
en-wikipedia-org-4107	2233	474	compound	compound	NN
en-wikipedia-org-4107	2233	475	articles	article	NNS
en-wikipedia-org-4107	2233	476	.	.	.
en-wikipedia-org-4107	2234	1	For	for	IN
en-wikipedia-org-4107	2234	2	TAAR2	taar2	NN
en-wikipedia-org-4107	2234	3	and	and	CC
en-wikipedia-org-4107	2234	4	TAAR5	taar5	JJ
en-wikipedia-org-4107	2234	5	agonists	agonist	NNS
en-wikipedia-org-4107	2234	6	and	and	CC
en-wikipedia-org-4107	2234	7	inverse	inverse	NN
en-wikipedia-org-4107	2234	8	agonists	agonist	NNS
en-wikipedia-org-4107	2234	9	,	,	,
en-wikipedia-org-4107	2234	10	see	see	VB
en-wikipedia-org-4107	2234	11	TAAR	TAAR	NNP
en-wikipedia-org-4107	2234	12	for	for	IN
en-wikipedia-org-4107	2234	13	references	reference	NNS
en-wikipedia-org-4107	2234	14	.	.	.
en-wikipedia-org-4107	2235	1	See	see	VB
en-wikipedia-org-4107	2235	2	also	also	RB
en-wikipedia-org-4107	2235	3	:	:	:
en-wikipedia-org-4107	2235	4	Receptor	Receptor	NNP
en-wikipedia-org-4107	2235	5	/	/	SYM
en-wikipedia-org-4107	2235	6	signaling	signal	VBG
en-wikipedia-org-4107	2235	7	modulators	modulator	NNS
en-wikipedia-org-4107	2235	8	v	v	IN
en-wikipedia-org-4107	2235	9	t	t	NN
en-wikipedia-org-4107	2235	10	e	e	NNP
en-wikipedia-org-4107	2235	11	Monoamine	Monoamine	NNP
en-wikipedia-org-4107	2235	12	releasing	release	VBG
en-wikipedia-org-4107	2235	13	agents	agent	NNS
en-wikipedia-org-4107	2235	14	DRAs	dra	VBZ
en-wikipedia-org-4107	2235	15	Morpholines	morpholine	NNS
en-wikipedia-org-4107	2235	16	:	:	:
en-wikipedia-org-4107	2235	17	Fenbutrazate	Fenbutrazate	NNP
en-wikipedia-org-4107	2235	18	Fenmetramide	Fenmetramide	NNP
en-wikipedia-org-4107	2235	19	Morazone	Morazone	NNP
en-wikipedia-org-4107	2235	20	Morforex	Morforex	NNP
en-wikipedia-org-4107	2235	21	Phendimetrazine	Phendimetrazine	NNP
en-wikipedia-org-4107	2235	22	Phenmetrazine	Phenmetrazine	NNP
en-wikipedia-org-4107	2235	23	Pseudophenmetrazine	Pseudophenmetrazine	NNP
en-wikipedia-org-4107	2235	24	Oxazolines	Oxazolines	NNPS
en-wikipedia-org-4107	2235	25	:	:	:
en-wikipedia-org-4107	2235	26	4-MAR	4-mar	CD
en-wikipedia-org-4107	2235	27	Aminorex	Aminorex	NNP
en-wikipedia-org-4107	2235	28	Clominorex	Clominorex	NNP
en-wikipedia-org-4107	2235	29	Cyclazodone	Cyclazodone	NNP
en-wikipedia-org-4107	2235	30	Fenozolone	Fenozolone	NNP
en-wikipedia-org-4107	2235	31	Fluminorex	Fluminorex	NNP
en-wikipedia-org-4107	2235	32	Pemoline	Pemoline	NNP
en-wikipedia-org-4107	2235	33	Thozalinone	Thozalinone	NNP
en-wikipedia-org-4107	2235	34	Phenethylamines	Phenethylamines	NNPS
en-wikipedia-org-4107	2235	35	:	:	:
en-wikipedia-org-4107	2235	36	2-OH	2-oh	CD
en-wikipedia-org-4107	2235	37	-	-	HYPH
en-wikipedia-org-4107	2235	38	PEA	PEA	NNP
en-wikipedia-org-4107	2235	39	4-CAB	4-cab	CD
en-wikipedia-org-4107	2235	40	4-FA	4-fa	CD
en-wikipedia-org-4107	2235	41	4-FMA	4-fma	CD
en-wikipedia-org-4107	2235	42	4-MA	4-ma	CD
en-wikipedia-org-4107	2235	43	4-MMA	4-mma	CD
en-wikipedia-org-4107	2235	44	Alfetamine	Alfetamine	NNP
en-wikipedia-org-4107	2235	45	Amfecloral	Amfecloral	NNP
en-wikipedia-org-4107	2235	46	Amfepentorex	Amfepentorex	NNP
en-wikipedia-org-4107	2235	47	Amfepramone	Amfepramone	NNP
en-wikipedia-org-4107	2235	48	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2235	49	(	(	-LRB-
en-wikipedia-org-4107	2235	50	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	2235	51	Levoamphetamine	Levoamphetamine	NNP
en-wikipedia-org-4107	2235	52	)	)	-RRB-
en-wikipedia-org-4107	2235	53	Amphetaminil	Amphetaminil	NNP
en-wikipedia-org-4107	2235	54	β	β	NNP
en-wikipedia-org-4107	2235	55	-	-	HYPH
en-wikipedia-org-4107	2235	56	Me	me	IN
en-wikipedia-org-4107	2235	57	-	-	HYPH
en-wikipedia-org-4107	2235	58	PEA	pea	NN
en-wikipedia-org-4107	2235	59	BDB	bdb	NN
en-wikipedia-org-4107	2235	60	BOH	boh	NN
en-wikipedia-org-4107	2235	61	Benzphetamine	benzphetamine	NN
en-wikipedia-org-4107	2235	62	Buphedrone	Buphedrone	NNP
en-wikipedia-org-4107	2235	63	Butylone	Butylone	NNP
en-wikipedia-org-4107	2235	64	Cathine	Cathine	NNP
en-wikipedia-org-4107	2235	65	Cathinone	Cathinone	NNP
en-wikipedia-org-4107	2235	66	Clobenzorex	Clobenzorex	NNP
en-wikipedia-org-4107	2235	67	Clortermine	Clortermine	NNP
en-wikipedia-org-4107	2235	68	D	D	NNP
en-wikipedia-org-4107	2235	69	-	-	HYPH
en-wikipedia-org-4107	2235	70	Deprenyl	Deprenyl	NNP
en-wikipedia-org-4107	2235	71	DMA	DMA	NNP
en-wikipedia-org-4107	2235	72	DMMA	DMMA	NNP
en-wikipedia-org-4107	2235	73	Dimethylamphetamine	Dimethylamphetamine	NNP
en-wikipedia-org-4107	2235	74	Ephedrine	Ephedrine	NNP
en-wikipedia-org-4107	2235	75	Ethcathinone	Ethcathinone	NNP
en-wikipedia-org-4107	2235	76	EBDB	ebdb	NN
en-wikipedia-org-4107	2235	77	Ethylone	Ethylone	NNP
en-wikipedia-org-4107	2235	78	Etilamfetamine	Etilamfetamine	NNP
en-wikipedia-org-4107	2235	79	Famprofazone	Famprofazone	NNP
en-wikipedia-org-4107	2235	80	Fenethylline	Fenethylline	NNP
en-wikipedia-org-4107	2235	81	Fenproporex	Fenproporex	NNP
en-wikipedia-org-4107	2235	82	Flephedrone	Flephedrone	NNP
en-wikipedia-org-4107	2235	83	Fludorex	Fludorex	NNP
en-wikipedia-org-4107	2235	84	Furfenorex	Furfenorex	NNP
en-wikipedia-org-4107	2235	85	Hordenine	Hordenine	NNP
en-wikipedia-org-4107	2235	86	4-Hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	2235	87	Iofetamine	Iofetamine	NNP
en-wikipedia-org-4107	2235	88	(	(	-LRB-
en-wikipedia-org-4107	2235	89	123I	123i	LS
en-wikipedia-org-4107	2235	90	)	)	-RRB-
en-wikipedia-org-4107	2235	91	Lophophine	Lophophine	NNP
en-wikipedia-org-4107	2235	92	Mefenorex	Mefenorex	NNP
en-wikipedia-org-4107	2235	93	Mephedrone	Mephedrone	NNP
en-wikipedia-org-4107	2235	94	Metamfepramone	Metamfepramone	NNP
en-wikipedia-org-4107	2235	95	Methamphetamine	Methamphetamine	NNP
en-wikipedia-org-4107	2235	96	Dextromethamphetamine	Dextromethamphetamine	NNP
en-wikipedia-org-4107	2235	97	Levomethamphetamine	Levomethamphetamine	NNP
en-wikipedia-org-4107	2235	98	Methcathinone	Methcathinone	NNP
en-wikipedia-org-4107	2235	99	Methedrone	Methedrone	NNP
en-wikipedia-org-4107	2235	100	MMDA	MMDA	NNP
en-wikipedia-org-4107	2235	101	MMDMA	MMDMA	NNP
en-wikipedia-org-4107	2235	102	MBDB	MBDB	NNPS
en-wikipedia-org-4107	2235	103	MDA	MDA	NNP
en-wikipedia-org-4107	2235	104	(	(	-LRB-
en-wikipedia-org-4107	2235	105	tenamfetamine	tenamfetamine	NN
en-wikipedia-org-4107	2235	106	)	)	-RRB-
en-wikipedia-org-4107	2235	107	MDEA	MDEA	NNP
en-wikipedia-org-4107	2235	108	MDMA	MDMA	NNP
en-wikipedia-org-4107	2235	109	(	(	-LRB-
en-wikipedia-org-4107	2235	110	midomafetamine	midomafetamine	NN
en-wikipedia-org-4107	2235	111	)	)	-RRB-
en-wikipedia-org-4107	2235	112	MDMPEA	mdmpea	RB
en-wikipedia-org-4107	2235	113	MDOH	MDOH	NNS
en-wikipedia-org-4107	2235	114	MDPEA	mdpea	NN
en-wikipedia-org-4107	2235	115	Methylone	Methylone	NNP
en-wikipedia-org-4107	2235	116	Morforex	Morforex	NNP
en-wikipedia-org-4107	2235	117	Ortetamine	Ortetamine	NNP
en-wikipedia-org-4107	2235	118	pBA	pba	VB
en-wikipedia-org-4107	2235	119	pCA	pCA	NNS
en-wikipedia-org-4107	2235	120	pIA	pia	IN
en-wikipedia-org-4107	2235	121	Pholedrine	Pholedrine	NNP
en-wikipedia-org-4107	2235	122	Phenethylamine	Phenethylamine	NNP
en-wikipedia-org-4107	2235	123	Pholedrine	Pholedrine	NNP
en-wikipedia-org-4107	2235	124	Phenpromethamine	Phenpromethamine	NNP
en-wikipedia-org-4107	2235	125	Prenylamine	Prenylamine	NNP
en-wikipedia-org-4107	2235	126	Propylamphetamine	Propylamphetamine	NNP
en-wikipedia-org-4107	2235	127	Pseudoephedrine	Pseudoephedrine	NNP
en-wikipedia-org-4107	2235	128	Tiflorex	Tiflorex	NNP
en-wikipedia-org-4107	2235	129	Tyramine	Tyramine	NNP
en-wikipedia-org-4107	2235	130	Xylopropamine	Xylopropamine	NNP
en-wikipedia-org-4107	2235	131	Zylofuramine	Zylofuramine	NNP
en-wikipedia-org-4107	2235	132	Piperazines	Piperazines	NNPS
en-wikipedia-org-4107	2235	133	:	:	:
en-wikipedia-org-4107	2235	134	2C	2c	JJ
en-wikipedia-org-4107	2235	135	-	-	HYPH
en-wikipedia-org-4107	2235	136	B	b	NN
en-wikipedia-org-4107	2235	137	-	-	HYPH
en-wikipedia-org-4107	2235	138	BZP	BZP	NNP
en-wikipedia-org-4107	2235	139	BZP	BZP	NNP
en-wikipedia-org-4107	2235	140	MBZP	MBZP	NNS
en-wikipedia-org-4107	2235	141	MDBZP	MDBZP	NNP
en-wikipedia-org-4107	2235	142	MeOPP	MeOPP	NNP
en-wikipedia-org-4107	2235	143	oMPP	ompp	NN
en-wikipedia-org-4107	2235	144	Others	other	NNS
en-wikipedia-org-4107	2235	145	:	:	:
en-wikipedia-org-4107	2235	146	2-ADN	2-adn	CD
en-wikipedia-org-4107	2235	147	2-AI	2-ai	CD
en-wikipedia-org-4107	2235	148	2-AT	2-at	CD
en-wikipedia-org-4107	2235	149	4-BP	4-bp	CD
en-wikipedia-org-4107	2235	150	5-APDI	5-APDI	NNP
en-wikipedia-org-4107	2235	151	5-IAI	5-IAI	NNP
en-wikipedia-org-4107	2235	152	Amineptine	Amineptine	NNP
en-wikipedia-org-4107	2235	153	Clofenciclan	Clofenciclan	NNP
en-wikipedia-org-4107	2235	154	Cyclopentamine	Cyclopentamine	NNP
en-wikipedia-org-4107	2235	155	Cypenamine	Cypenamine	NNP
en-wikipedia-org-4107	2235	156	Cyprodenate	Cyprodenate	NNP
en-wikipedia-org-4107	2235	157	Feprosidnine	feprosidnine	NN
en-wikipedia-org-4107	2235	158	Gilutensin	Gilutensin	NNP
en-wikipedia-org-4107	2235	159	Heptaminol	Heptaminol	NNP
en-wikipedia-org-4107	2235	160	Hexacyclonate	Hexacyclonate	NNP
en-wikipedia-org-4107	2235	161	Indanorex	Indanorex	NNP
en-wikipedia-org-4107	2235	162	Isometheptene	Isometheptene	NNP
en-wikipedia-org-4107	2235	163	Methylhexanamine	Methylhexanamine	NNP
en-wikipedia-org-4107	2235	164	Naphthylaminopropane	Naphthylaminopropane	NNP
en-wikipedia-org-4107	2235	165	Octodrine	Octodrine	NNP
en-wikipedia-org-4107	2235	166	Phthalimidopropiophenone	Phthalimidopropiophenone	NNP
en-wikipedia-org-4107	2235	167	Phenylbiguanide	Phenylbiguanide	NNP
en-wikipedia-org-4107	2235	168	Propylhexedrine	Propylhexedrine	NNP
en-wikipedia-org-4107	2235	169	Levopropylhexedrine	Levopropylhexedrine	NNP
en-wikipedia-org-4107	2235	170	NRAs	nra	NNS
en-wikipedia-org-4107	2235	171	Morpholines	morpholine	NNS
en-wikipedia-org-4107	2235	172	:	:	:
en-wikipedia-org-4107	2235	173	Fenbutrazate	Fenbutrazate	NNP
en-wikipedia-org-4107	2235	174	Fenmetramide	Fenmetramide	NNP
en-wikipedia-org-4107	2235	175	Morazone	Morazone	NNP
en-wikipedia-org-4107	2235	176	Morforex	Morforex	NNP
en-wikipedia-org-4107	2235	177	Phendimetrazine	Phendimetrazine	NNP
en-wikipedia-org-4107	2235	178	Phenmetrazine	Phenmetrazine	NNP
en-wikipedia-org-4107	2235	179	Pseudophenmetrazine	Pseudophenmetrazine	NNP
en-wikipedia-org-4107	2235	180	Oxazolines	Oxazolines	NNPS
en-wikipedia-org-4107	2235	181	:	:	:
en-wikipedia-org-4107	2235	182	4-MAR	4-mar	CD
en-wikipedia-org-4107	2235	183	Aminorex	Aminorex	NNP
en-wikipedia-org-4107	2235	184	Clominorex	Clominorex	NNP
en-wikipedia-org-4107	2235	185	Cyclazodone	Cyclazodone	NNP
en-wikipedia-org-4107	2235	186	Fenozolone	Fenozolone	NNP
en-wikipedia-org-4107	2235	187	Fluminorex	Fluminorex	NNP
en-wikipedia-org-4107	2235	188	Pemoline	Pemoline	NNP
en-wikipedia-org-4107	2235	189	Thozalinone	Thozalinone	NNP
en-wikipedia-org-4107	2235	190	Phenethylamines	Phenethylamines	NNPS
en-wikipedia-org-4107	2235	191	:	:	:
en-wikipedia-org-4107	2235	192	2-OH	2-oh	CD
en-wikipedia-org-4107	2235	193	-	-	HYPH
en-wikipedia-org-4107	2235	194	PEA	PEA	NNP
en-wikipedia-org-4107	2235	195	4-CAB	4-cab	CD
en-wikipedia-org-4107	2235	196	4-FA	4-fa	CD
en-wikipedia-org-4107	2235	197	4-FMA	4-fma	CD
en-wikipedia-org-4107	2235	198	4-MA	4-ma	CD
en-wikipedia-org-4107	2235	199	4-MMA	4-mma	CD
en-wikipedia-org-4107	2235	200	Alfetamine	Alfetamine	NNP
en-wikipedia-org-4107	2235	201	Amfecloral	Amfecloral	NNP
en-wikipedia-org-4107	2235	202	Amfepentorex	Amfepentorex	NNP
en-wikipedia-org-4107	2235	203	Amfepramone	Amfepramone	NNP
en-wikipedia-org-4107	2235	204	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2235	205	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	2235	206	Levoamphetamine	Levoamphetamine	NNP
en-wikipedia-org-4107	2235	207	Amphetaminil	Amphetaminil	NNP
en-wikipedia-org-4107	2235	208	β	β	NNP
en-wikipedia-org-4107	2235	209	-	-	HYPH
en-wikipedia-org-4107	2235	210	Me	me	IN
en-wikipedia-org-4107	2235	211	-	-	HYPH
en-wikipedia-org-4107	2235	212	PEA	PEA	NNP
en-wikipedia-org-4107	2235	213	BDB	BDB	NNP
en-wikipedia-org-4107	2235	214	Benzphetamine	benzphetamine	NN
en-wikipedia-org-4107	2235	215	BOH	BOH	NNP
en-wikipedia-org-4107	2235	216	Buphedrone	Buphedrone	NNP
en-wikipedia-org-4107	2235	217	Butylone	Butylone	NNP
en-wikipedia-org-4107	2235	218	Cathine	Cathine	NNP
en-wikipedia-org-4107	2235	219	Cathinone	Cathinone	NNP
en-wikipedia-org-4107	2235	220	Clobenzorex	Clobenzorex	NNP
en-wikipedia-org-4107	2235	221	Clortermine	Clortermine	NNP
en-wikipedia-org-4107	2235	222	Dimethylamphetamine	Dimethylamphetamine	NNP
en-wikipedia-org-4107	2235	223	DMA	DMA	NNP
en-wikipedia-org-4107	2235	224	DMMA	DMMA	NNS
en-wikipedia-org-4107	2235	225	EBDB	EBDB	VBG
en-wikipedia-org-4107	2235	226	Ephedrine	ephedrine	NN
en-wikipedia-org-4107	2235	227	Ethcathinone	Ethcathinone	NNP
en-wikipedia-org-4107	2235	228	Ethylone	Ethylone	NNP
en-wikipedia-org-4107	2235	229	Etilamfetamine	Etilamfetamine	NNP
en-wikipedia-org-4107	2235	230	Famprofazone	Famprofazone	NNP
en-wikipedia-org-4107	2235	231	Fenethylline	Fenethylline	NNP
en-wikipedia-org-4107	2235	232	Fenproporex	Fenproporex	NNP
en-wikipedia-org-4107	2235	233	Flephedrone	Flephedrone	NNP
en-wikipedia-org-4107	2235	234	Fludorex	Fludorex	NNP
en-wikipedia-org-4107	2235	235	Furfenorex	Furfenorex	NNP
en-wikipedia-org-4107	2235	236	Hordenine	Hordenine	NNP
en-wikipedia-org-4107	2235	237	4-Hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	2235	238	5-APDI	5-apdi	JJ
en-wikipedia-org-4107	2235	239	(	(	-LRB-
en-wikipedia-org-4107	2235	240	IAP	IAP	NNP
en-wikipedia-org-4107	2235	241	)	)	-RRB-
en-wikipedia-org-4107	2235	242	Iofetamine	Iofetamine	NNP
en-wikipedia-org-4107	2235	243	(	(	-LRB-
en-wikipedia-org-4107	2235	244	123I	123i	CD
en-wikipedia-org-4107	2235	245	)	)	-RRB-
en-wikipedia-org-4107	2235	246	Lisdexamfetamine	Lisdexamfetamine	NNP
en-wikipedia-org-4107	2235	247	Lophophine	Lophophine	NNP
en-wikipedia-org-4107	2235	248	MBDB	MBDB	NNP
en-wikipedia-org-4107	2235	249	MDA	MDA	NNP
en-wikipedia-org-4107	2235	250	(	(	-LRB-
en-wikipedia-org-4107	2235	251	tenamfetamine	tenamfetamine	NN
en-wikipedia-org-4107	2235	252	)	)	-RRB-
en-wikipedia-org-4107	2235	253	MDEA	MDEA	NNP
en-wikipedia-org-4107	2235	254	MDMA	MDMA	NNP
en-wikipedia-org-4107	2235	255	(	(	-LRB-
en-wikipedia-org-4107	2235	256	midomafetamine	midomafetamine	NN
en-wikipedia-org-4107	2235	257	)	)	-RRB-
en-wikipedia-org-4107	2235	258	Metamfepramone	Metamfepramone	NNP
en-wikipedia-org-4107	2235	259	MDMPEA	mdmpea	RB
en-wikipedia-org-4107	2235	260	MDOH	MDOH	NNS
en-wikipedia-org-4107	2235	261	MDPEA	mdpea	NN
en-wikipedia-org-4107	2235	262	Mefenorex	Mefenorex	NNP
en-wikipedia-org-4107	2235	263	Mephedrone	Mephedrone	NNP
en-wikipedia-org-4107	2235	264	Mephentermine	Mephentermine	NNP
en-wikipedia-org-4107	2235	265	Methamphetamine	Methamphetamine	NNP
en-wikipedia-org-4107	2235	266	Dextromethamphetamine	Dextromethamphetamine	NNP
en-wikipedia-org-4107	2235	267	Levomethamphetamine	Levomethamphetamine	NNP
en-wikipedia-org-4107	2235	268	Methcathinone	Methcathinone	NNP
en-wikipedia-org-4107	2235	269	Methedrone	Methedrone	NNP
en-wikipedia-org-4107	2235	270	Methylone	Methylone	NNP
en-wikipedia-org-4107	2235	271	Morforex	Morforex	NNP
en-wikipedia-org-4107	2235	272	Naphthylaminopropane	Naphthylaminopropane	NNP
en-wikipedia-org-4107	2235	273	Ortetamine	Ortetamine	NNP
en-wikipedia-org-4107	2235	274	pBA	pBA	VBD
en-wikipedia-org-4107	2235	275	pCA	pca	CD
en-wikipedia-org-4107	2235	276	Pentorex	Pentorex	NNP
en-wikipedia-org-4107	2235	277	Phenethylamine	Phenethylamine	NNP
en-wikipedia-org-4107	2235	278	Pholedrine	Pholedrine	NNP
en-wikipedia-org-4107	2235	279	Phenpromethamine	Phenpromethamine	NNP
en-wikipedia-org-4107	2235	280	Phentermine	Phentermine	NNP
en-wikipedia-org-4107	2235	281	Phenylpropanolamine	Phenylpropanolamine	NNP
en-wikipedia-org-4107	2235	282	pIA	pIA	VBD
en-wikipedia-org-4107	2235	283	Prenylamine	Prenylamine	NNP
en-wikipedia-org-4107	2235	284	Propylamphetamine	Propylamphetamine	NNP
en-wikipedia-org-4107	2235	285	Pseudoephedrine	Pseudoephedrine	NNP
en-wikipedia-org-4107	2235	286	Selegiline	Selegiline	NNP
en-wikipedia-org-4107	2235	287	(	(	-LRB-
en-wikipedia-org-4107	2235	288	also	also	RB
en-wikipedia-org-4107	2235	289	D	D	NNP
en-wikipedia-org-4107	2235	290	-	-	HYPH
en-wikipedia-org-4107	2235	291	Deprenyl	deprenyl	NN
en-wikipedia-org-4107	2235	292	)	)	-RRB-
en-wikipedia-org-4107	2235	293	Tiflorex	Tiflorex	NNP
en-wikipedia-org-4107	2235	294	Tyramine	Tyramine	NNP
en-wikipedia-org-4107	2235	295	Xylopropamine	Xylopropamine	NNP
en-wikipedia-org-4107	2235	296	Zylofuramine	Zylofuramine	NNP
en-wikipedia-org-4107	2235	297	Piperazines	Piperazines	NNPS
en-wikipedia-org-4107	2235	298	:	:	:
en-wikipedia-org-4107	2235	299	2C	2c	JJ
en-wikipedia-org-4107	2235	300	-	-	HYPH
en-wikipedia-org-4107	2235	301	B	b	NN
en-wikipedia-org-4107	2235	302	-	-	HYPH
en-wikipedia-org-4107	2235	303	BZP	bzp	NN
en-wikipedia-org-4107	2235	304	BZP	BZP	NNP
en-wikipedia-org-4107	2235	305	MBZP	MBZP	NNP
en-wikipedia-org-4107	2235	306	mCPP	mcpp	NN
en-wikipedia-org-4107	2235	307	MDBZP	MDBZP	NNP
en-wikipedia-org-4107	2235	308	MeOPP	MeOPP	NNP
en-wikipedia-org-4107	2235	309	oMPP	ompp	NN
en-wikipedia-org-4107	2235	310	pFPP	pfpp	NN
en-wikipedia-org-4107	2235	311	Others	other	NNS
en-wikipedia-org-4107	2235	312	:	:	:
en-wikipedia-org-4107	2235	313	2-ADN	2-adn	CD
en-wikipedia-org-4107	2235	314	2-AI	2-ai	CD
en-wikipedia-org-4107	2235	315	2-AT	2-at	CD
en-wikipedia-org-4107	2235	316	2-BP	2-bp	CD
en-wikipedia-org-4107	2235	317	4-BP	4-bp	CD
en-wikipedia-org-4107	2235	318	5-IAI	5-iai	CD
en-wikipedia-org-4107	2235	319	Clofenciclan	Clofenciclan	NNP
en-wikipedia-org-4107	2235	320	Cyclopentamine	Cyclopentamine	NNP
en-wikipedia-org-4107	2235	321	Cypenamine	Cypenamine	NNP
en-wikipedia-org-4107	2235	322	Cyprodenate	Cyprodenate	NNP
en-wikipedia-org-4107	2235	323	Feprosidnine	feprosidnine	NN
en-wikipedia-org-4107	2235	324	Gilutensin	Gilutensin	NNP
en-wikipedia-org-4107	2235	325	Heptaminol	Heptaminol	NNP
en-wikipedia-org-4107	2235	326	Hexacyclonate	Hexacyclonate	NNP
en-wikipedia-org-4107	2235	327	Indanorex	Indanorex	NNP
en-wikipedia-org-4107	2235	328	Isometheptene	Isometheptene	NNP
en-wikipedia-org-4107	2235	329	Methylhexanamine	Methylhexanamine	NNP
en-wikipedia-org-4107	2235	330	Octodrine	Octodrine	NNP
en-wikipedia-org-4107	2235	331	Phthalimidopropiophenone	Phthalimidopropiophenone	NNP
en-wikipedia-org-4107	2235	332	Propylhexedrine	Propylhexedrine	NNP
en-wikipedia-org-4107	2235	333	(	(	-LRB-
en-wikipedia-org-4107	2235	334	Levopropylhexedrine	Levopropylhexedrine	NNP
en-wikipedia-org-4107	2235	335	)	)	-RRB-
en-wikipedia-org-4107	2235	336	Tuaminoheptane	tuaminoheptane	NN
en-wikipedia-org-4107	2235	337	SRAs	sra	NNS
en-wikipedia-org-4107	2235	338	Aminoindanes	aminoindane	NNS
en-wikipedia-org-4107	2235	339	:	:	:
en-wikipedia-org-4107	2235	340	5-IAI	5-iai	CD
en-wikipedia-org-4107	2235	341	AMMI	ammi	NN
en-wikipedia-org-4107	2235	342	ETAI	etai	NN
en-wikipedia-org-4107	2235	343	MDAI	MDAI	NNS
en-wikipedia-org-4107	2235	344	MDMAI	MDMAI	NNS
en-wikipedia-org-4107	2235	345	MMAI	MMAI	NNP
en-wikipedia-org-4107	2235	346	TAI	TAI	NNP
en-wikipedia-org-4107	2235	347	Aminotetralins	aminotetralin	NNS
en-wikipedia-org-4107	2235	348	:	:	:
en-wikipedia-org-4107	2235	349	6-CAT	6-cat	CD
en-wikipedia-org-4107	2235	350	8-OH	8-oh	CD
en-wikipedia-org-4107	2235	351	-	-	HYPH
en-wikipedia-org-4107	2235	352	DPAT	DPAT	NNP
en-wikipedia-org-4107	2235	353	MDAT	MDAT	NNP
en-wikipedia-org-4107	2235	354	MDMAT	MDMAT	NNP
en-wikipedia-org-4107	2235	355	Oxazolines	Oxazolines	NNPS
en-wikipedia-org-4107	2235	356	:	:	:
en-wikipedia-org-4107	2235	357	4-Methylaminorex	4-methylaminorex	CD
en-wikipedia-org-4107	2235	358	Aminorex	Aminorex	NNP
en-wikipedia-org-4107	2235	359	Clominorex	Clominorex	NNP
en-wikipedia-org-4107	2235	360	Fluminorex	Fluminorex	NNP
en-wikipedia-org-4107	2235	361	Phenethylamines	Phenethylamines	NNPS
en-wikipedia-org-4107	2235	362	:	:	:
en-wikipedia-org-4107	2235	363	2-Methyl	2-methyl	CD
en-wikipedia-org-4107	2235	364	-	-	HYPH
en-wikipedia-org-4107	2235	365	MDA	MDA	NNP
en-wikipedia-org-4107	2235	366	4-CAB	4-CAB	NNP
en-wikipedia-org-4107	2235	367	4-FA	4-fa	CD
en-wikipedia-org-4107	2235	368	4-FMA	4-fma	CD
en-wikipedia-org-4107	2235	369	4-HA	4-ha	CD
en-wikipedia-org-4107	2235	370	4-MTA	4-MTA	NNP
en-wikipedia-org-4107	2235	371	5-APDB	5-APDB	NNP
en-wikipedia-org-4107	2235	372	5-Methyl	5-methyl	CD
en-wikipedia-org-4107	2235	373	-	-	HYPH
en-wikipedia-org-4107	2235	374	MDA	mda	NN
en-wikipedia-org-4107	2235	375	6-APDB	6-APDB	NNP
en-wikipedia-org-4107	2235	376	6-Methyl	6-methyl	CD
en-wikipedia-org-4107	2235	377	-	-	HYPH
en-wikipedia-org-4107	2235	378	MDA	MDA	NNP
en-wikipedia-org-4107	2235	379	AEMMA	aemma	IN
en-wikipedia-org-4107	2235	380	Amiflamine	Amiflamine	NNP
en-wikipedia-org-4107	2235	381	BDB	BDB	NNP
en-wikipedia-org-4107	2235	382	BOH	BOH	NNP
en-wikipedia-org-4107	2235	383	Brephedrone	Brephedrone	NNP
en-wikipedia-org-4107	2235	384	Butylone	Butylone	NNP
en-wikipedia-org-4107	2235	385	Chlorphentermine	Chlorphentermine	NNP
en-wikipedia-org-4107	2235	386	Cloforex	Cloforex	NNP
en-wikipedia-org-4107	2235	387	Amfepramone	Amfepramone	NNP
en-wikipedia-org-4107	2235	388	Metamfepramone	Metamfepramone	NNP
en-wikipedia-org-4107	2235	389	DCA	DCA	NNP
en-wikipedia-org-4107	2235	390	Dexfenfluramine	Dexfenfluramine	NNP
en-wikipedia-org-4107	2235	391	DFMDA	DFMDA	NNP
en-wikipedia-org-4107	2235	392	DMA	dma	NN
en-wikipedia-org-4107	2235	393	DMMA	DMMA	NNS
en-wikipedia-org-4107	2235	394	EBDB	EBDB	VBG
en-wikipedia-org-4107	2235	395	EDMA	EDMA	NNS
en-wikipedia-org-4107	2235	396	Ethylone	Ethylone	NNP
en-wikipedia-org-4107	2235	397	Etolorex	Etolorex	NNP
en-wikipedia-org-4107	2235	398	Fenfluramine	Fenfluramine	NNP
en-wikipedia-org-4107	2235	399	Flephedrone	Flephedrone	NNP
en-wikipedia-org-4107	2235	400	Flucetorex	Flucetorex	NNP
en-wikipedia-org-4107	2235	401	IAP	IAP	NNP
en-wikipedia-org-4107	2235	402	Iofetamine	Iofetamine	NNP
en-wikipedia-org-4107	2235	403	Levofenfluramine	Levofenfluramine	NNP
en-wikipedia-org-4107	2235	404	Lophophine	Lophophine	NNP
en-wikipedia-org-4107	2235	405	MBDB	MBDB	NNP
en-wikipedia-org-4107	2235	406	MDA	MDA	NNP
en-wikipedia-org-4107	2235	407	(	(	-LRB-
en-wikipedia-org-4107	2235	408	tenamfetamine	tenamfetamine	NN
en-wikipedia-org-4107	2235	409	)	)	-RRB-
en-wikipedia-org-4107	2235	410	MDEA	MDEA	NNP
en-wikipedia-org-4107	2235	411	MDHMA	MDHMA	NNP
en-wikipedia-org-4107	2235	412	MDMA	MDMA	NNP
en-wikipedia-org-4107	2235	413	(	(	-LRB-
en-wikipedia-org-4107	2235	414	midomafetamine	midomafetamine	NN
en-wikipedia-org-4107	2235	415	)	)	-RRB-
en-wikipedia-org-4107	2235	416	MDMPEA	mdmpea	RB
en-wikipedia-org-4107	2235	417	MDOH	MDOH	NNS
en-wikipedia-org-4107	2235	418	MDPEA	mdpea	NN
en-wikipedia-org-4107	2235	419	Mephedrone	Mephedrone	NNP
en-wikipedia-org-4107	2235	420	Methedrone	Methedrone	NNP
en-wikipedia-org-4107	2235	421	Methylone	Methylone	NNP
en-wikipedia-org-4107	2235	422	MMA	MMA	NNP
en-wikipedia-org-4107	2235	423	MMDA	MMDA	NNP
en-wikipedia-org-4107	2235	424	MMDMA	MMDMA	NNP
en-wikipedia-org-4107	2235	425	MMMA	MMMA	NNP
en-wikipedia-org-4107	2235	426	NAP	NAP	NNP
en-wikipedia-org-4107	2235	427	Norfenfluramine	Norfenfluramine	NNP
en-wikipedia-org-4107	2235	428	4-TFMA	4-TFMA	NNP
en-wikipedia-org-4107	2235	429	pBA	pba	NN
en-wikipedia-org-4107	2235	430	pCA	pCA	NNS
en-wikipedia-org-4107	2235	431	pIA	pia	CD
en-wikipedia-org-4107	2235	432	PMA	PMA	NNP
en-wikipedia-org-4107	2235	433	PMEA	PMEA	NNP
en-wikipedia-org-4107	2235	434	PMMA	PMMA	NNP
en-wikipedia-org-4107	2235	435	TAP	TAP	NNP
en-wikipedia-org-4107	2235	436	Piperazines	Piperazines	NNPS
en-wikipedia-org-4107	2235	437	:	:	:
en-wikipedia-org-4107	2235	438	2C	2c	JJ
en-wikipedia-org-4107	2235	439	-	-	HYPH
en-wikipedia-org-4107	2235	440	B	b	NN
en-wikipedia-org-4107	2235	441	-	-	HYPH
en-wikipedia-org-4107	2235	442	BZP	BZP	NNP
en-wikipedia-org-4107	2235	443	3-MeOPP	3-MeOPP	NNP
en-wikipedia-org-4107	2235	444	BZP	BZP	NNP
en-wikipedia-org-4107	2235	445	DCPP	DCPP	NNP
en-wikipedia-org-4107	2235	446	MBZP	MBZP	NNP
en-wikipedia-org-4107	2235	447	mCPP	mcpp	NN
en-wikipedia-org-4107	2235	448	MDBZP	MDBZP	NNP
en-wikipedia-org-4107	2235	449	MeOPP	MeOPP	NNP
en-wikipedia-org-4107	2235	450	Mepiprazole	Mepiprazole	NNP
en-wikipedia-org-4107	2235	451	oMPP	ompp	NN
en-wikipedia-org-4107	2235	452	pCPP	pcpp	NN
en-wikipedia-org-4107	2235	453	pFPP	pfpp	JJ
en-wikipedia-org-4107	2235	454	pTFMPP	ptfmpp	NN
en-wikipedia-org-4107	2235	455	TFMPP	TFMPP	NNP
en-wikipedia-org-4107	2235	456	Tryptamines	Tryptamines	NNPS
en-wikipedia-org-4107	2235	457	:	:	:
en-wikipedia-org-4107	2235	458	4-Methyl	4-methyl	CD
en-wikipedia-org-4107	2235	459	-	-	HYPH
en-wikipedia-org-4107	2235	460	αET	αet	CD
en-wikipedia-org-4107	2235	461	4-Methyl	4-methyl	CD
en-wikipedia-org-4107	2235	462	-	-	HYPH
en-wikipedia-org-4107	2235	463	αMT	αmt	CD
en-wikipedia-org-4107	2235	464	5-CT	5-ct	CD
en-wikipedia-org-4107	2235	465	5-MeO	5-meo	CD
en-wikipedia-org-4107	2235	466	-	-	HYPH
en-wikipedia-org-4107	2235	467	αET	αet	CD
en-wikipedia-org-4107	2235	468	5-MeO	5-meo	CD
en-wikipedia-org-4107	2235	469	-	-	:
en-wikipedia-org-4107	2235	470	αMT	αMT	NNS
en-wikipedia-org-4107	2235	471	5-MT	5-mt	CD
en-wikipedia-org-4107	2235	472	αET	αet	CD
en-wikipedia-org-4107	2235	473	αMT	αmt	IN
en-wikipedia-org-4107	2235	474	DMT	DMT	NNP
en-wikipedia-org-4107	2235	475	Tryptamine	Tryptamine	NNP
en-wikipedia-org-4107	2235	476	Others	Others	NNPS
en-wikipedia-org-4107	2235	477	:	:	:
en-wikipedia-org-4107	2235	478	Indeloxazine	Indeloxazine	NNP
en-wikipedia-org-4107	2235	479	Viqualine	Viqualine	NNP
en-wikipedia-org-4107	2235	480	Others	Others	NNP
en-wikipedia-org-4107	2235	481	Monoamine	Monoamine	NNP
en-wikipedia-org-4107	2235	482	activity	activity	NN
en-wikipedia-org-4107	2235	483	enhancers	enhancer	NNS
en-wikipedia-org-4107	2235	484	:	:	:
en-wikipedia-org-4107	2235	485	BPAP	BPAP	NNP
en-wikipedia-org-4107	2235	486	PPAP	PPAP	NNP
en-wikipedia-org-4107	2235	487	DAT	DAT	NNP
en-wikipedia-org-4107	2235	488	modulators	modulator	NNS
en-wikipedia-org-4107	2235	489	:	:	:
en-wikipedia-org-4107	2235	490	Agonist	agonist	NN
en-wikipedia-org-4107	2235	491	-	-	HYPH
en-wikipedia-org-4107	2235	492	like	like	JJ
en-wikipedia-org-4107	2235	493	:	:	:
en-wikipedia-org-4107	2235	494	SoRI-9804	SoRI-9804	NNP
en-wikipedia-org-4107	2235	495	SoRI-20040	SoRI-20040	NNP
en-wikipedia-org-4107	2235	496	;	;	:
en-wikipedia-org-4107	2235	497	Antagonist	antagonist	NN
en-wikipedia-org-4107	2235	498	-	-	HYPH
en-wikipedia-org-4107	2235	499	like	like	IN
en-wikipedia-org-4107	2235	500	:	:	:
en-wikipedia-org-4107	2235	501	SoRI-20041	SoRI-20041	NNP
en-wikipedia-org-4107	2235	502	Adrenergic	Adrenergic	NNP
en-wikipedia-org-4107	2235	503	release	release	NN
en-wikipedia-org-4107	2235	504	blockers	blocker	NNS
en-wikipedia-org-4107	2235	505	:	:	:
en-wikipedia-org-4107	2235	506	Bethanidine	Bethanidine	NNP
en-wikipedia-org-4107	2235	507	Bretylium	Bretylium	NNP
en-wikipedia-org-4107	2235	508	Guanadrel	Guanadrel	NNP
en-wikipedia-org-4107	2235	509	Guanazodine	Guanazodine	NNP
en-wikipedia-org-4107	2235	510	Guanethidine	Guanethidine	NNP
en-wikipedia-org-4107	2235	511	Guanoxan	Guanoxan	NNP
en-wikipedia-org-4107	2235	512	See	See	NNP
en-wikipedia-org-4107	2235	513	also	also	RB
en-wikipedia-org-4107	2235	514	:	:	:
en-wikipedia-org-4107	2235	515	Receptor	Receptor	NNP
en-wikipedia-org-4107	2235	516	/	/	SYM
en-wikipedia-org-4107	2235	517	signaling	signal	VBG
en-wikipedia-org-4107	2235	518	modulators	modulator	NNS
en-wikipedia-org-4107	2235	519	•	•	NNP
en-wikipedia-org-4107	2235	520	Monoamine	Monoamine	NNP
en-wikipedia-org-4107	2235	521	reuptake	reuptake	NN
en-wikipedia-org-4107	2235	522	inhibitors	inhibitor	NNS
en-wikipedia-org-4107	2235	523	•	•	NNP
en-wikipedia-org-4107	2235	524	Adrenergics	Adrenergics	NNP
en-wikipedia-org-4107	2235	525	•	•	NNP
en-wikipedia-org-4107	2235	526	Dopaminergics	dopaminergic	NNS
en-wikipedia-org-4107	2235	527	•	•	VBP
en-wikipedia-org-4107	2235	528	Serotonergics	serotonergic	NNS
en-wikipedia-org-4107	2235	529	•	•	VBP
en-wikipedia-org-4107	2235	530	Monoamine	Monoamine	NNP
en-wikipedia-org-4107	2235	531	metabolism	metabolism	NN
en-wikipedia-org-4107	2235	532	modulators	modulator	NNS
en-wikipedia-org-4107	2235	533	•	•	NNP
en-wikipedia-org-4107	2235	534	Monoamine	Monoamine	NNP
en-wikipedia-org-4107	2235	535	neurotoxins	neurotoxin	NNS
en-wikipedia-org-4107	2235	536	v	v	IN
en-wikipedia-org-4107	2235	537	t	t	NN
en-wikipedia-org-4107	2235	538	e	e	NNP
en-wikipedia-org-4107	2235	539	Phenethylamines	Phenethylamines	NNP
en-wikipedia-org-4107	2235	540	Phenethylamines	Phenethylamines	NNPS
en-wikipedia-org-4107	2235	541	Psychedelics	psychedelic	NNS
en-wikipedia-org-4107	2235	542	:	:	:
en-wikipedia-org-4107	2235	543	25B	25b	CD
en-wikipedia-org-4107	2235	544	-	-	HYPH
en-wikipedia-org-4107	2235	545	NBOMe	NBOMe	NNS
en-wikipedia-org-4107	2235	546	25C	25c	CD
en-wikipedia-org-4107	2235	547	-	-	HYPH
en-wikipedia-org-4107	2235	548	NBOMe	NBOMe	NNS
en-wikipedia-org-4107	2235	549	25D	25d	CD
en-wikipedia-org-4107	2235	550	-	-	HYPH
en-wikipedia-org-4107	2235	551	NBOMe	NBOMe	NNS
en-wikipedia-org-4107	2235	552	25I	25i	CD
en-wikipedia-org-4107	2235	553	-	-	HYPH
en-wikipedia-org-4107	2235	554	NBOMe	NBOMe	NNS
en-wikipedia-org-4107	2235	555	25N	25n	CD
en-wikipedia-org-4107	2235	556	-	-	HYPH
en-wikipedia-org-4107	2235	557	NBOMe	NBOMe	NNS
en-wikipedia-org-4107	2235	558	2C	2c	NN
en-wikipedia-org-4107	2235	559	-	-	HYPH
en-wikipedia-org-4107	2235	560	B	b	NN
en-wikipedia-org-4107	2235	561	2C	2c	NN
en-wikipedia-org-4107	2235	562	-	-	HYPH
en-wikipedia-org-4107	2235	563	B	b	NN
en-wikipedia-org-4107	2235	564	-	-	HYPH
en-wikipedia-org-4107	2235	565	AN	an	DT
en-wikipedia-org-4107	2235	566	2C	2c	NN
en-wikipedia-org-4107	2235	567	-	-	HYPH
en-wikipedia-org-4107	2235	568	Bn	bn	JJ
en-wikipedia-org-4107	2235	569	2C	2c	NN
en-wikipedia-org-4107	2235	570	-	-	HYPH
en-wikipedia-org-4107	2235	571	Bu	bu	JJ
en-wikipedia-org-4107	2235	572	2C	2c	NN
en-wikipedia-org-4107	2235	573	-	-	HYPH
en-wikipedia-org-4107	2235	574	C	C	NNP
en-wikipedia-org-4107	2235	575	2C	2c	NN
en-wikipedia-org-4107	2235	576	-	-	HYPH
en-wikipedia-org-4107	2235	577	CN	cn	NN
en-wikipedia-org-4107	2235	578	2C	2c	NN
en-wikipedia-org-4107	2235	579	-	-	HYPH
en-wikipedia-org-4107	2235	580	CP	CP	NNP
en-wikipedia-org-4107	2235	581	2C	2c	NN
en-wikipedia-org-4107	2235	582	-	-	:
en-wikipedia-org-4107	2235	583	D	d	JJ
en-wikipedia-org-4107	2235	584	2C	2c	JJ
en-wikipedia-org-4107	2235	585	-	-	HYPH
en-wikipedia-org-4107	2235	586	E	e	NN
en-wikipedia-org-4107	2235	587	2C	2c	JJ
en-wikipedia-org-4107	2235	588	-	-	HYPH
en-wikipedia-org-4107	2235	589	EF	EF	NNP
en-wikipedia-org-4107	2235	590	2C	2c	NN
en-wikipedia-org-4107	2235	591	-	-	HYPH
en-wikipedia-org-4107	2235	592	F	f	NN
en-wikipedia-org-4107	2235	593	2C	2c	NN
en-wikipedia-org-4107	2235	594	-	-	HYPH
en-wikipedia-org-4107	2235	595	G	g	NN
en-wikipedia-org-4107	2235	596	2C	2c	NN
en-wikipedia-org-4107	2235	597	-	-	HYPH
en-wikipedia-org-4107	2235	598	G-1	G-1	NNP
en-wikipedia-org-4107	2235	599	2C	2c	NN
en-wikipedia-org-4107	2235	600	-	-	HYPH
en-wikipedia-org-4107	2235	601	G-2	G-2	NNP
en-wikipedia-org-4107	2235	602	2C	2c	NN
en-wikipedia-org-4107	2235	603	-	-	:
en-wikipedia-org-4107	2235	604	G-3	G-3	NNP
en-wikipedia-org-4107	2235	605	2C	2c	NN
en-wikipedia-org-4107	2235	606	-	-	:
en-wikipedia-org-4107	2235	607	G-4	G-4	NNP
en-wikipedia-org-4107	2235	608	2C	2c	NN
en-wikipedia-org-4107	2235	609	-	-	HYPH
en-wikipedia-org-4107	2235	610	G-5	G-5	NNP
en-wikipedia-org-4107	2235	611	2C	2c	NN
en-wikipedia-org-4107	2235	612	-	-	HYPH
en-wikipedia-org-4107	2235	613	G-6	G-6	NNP
en-wikipedia-org-4107	2235	614	2C	2c	NN
en-wikipedia-org-4107	2235	615	-	-	HYPH
en-wikipedia-org-4107	2235	616	G	g	NN
en-wikipedia-org-4107	2235	617	-	-	HYPH
en-wikipedia-org-4107	2235	618	N	n	CD
en-wikipedia-org-4107	2235	619	2C	2c	JJ
en-wikipedia-org-4107	2235	620	-	-	HYPH
en-wikipedia-org-4107	2235	621	H	h	NN
en-wikipedia-org-4107	2235	622	2C	2c	NN
en-wikipedia-org-4107	2235	623	-	-	:
en-wikipedia-org-4107	2235	624	I	-PRON-	PRP
en-wikipedia-org-4107	2235	625	2C	2c	NN
en-wikipedia-org-4107	2235	626	-	-	HYPH
en-wikipedia-org-4107	2235	627	iP	iP	NNP
en-wikipedia-org-4107	2235	628	2C	2c	NN
en-wikipedia-org-4107	2235	629	-	-	HYPH
en-wikipedia-org-4107	2235	630	N	n	CD
en-wikipedia-org-4107	2235	631	2C	2c	JJ
en-wikipedia-org-4107	2235	632	-	-	HYPH
en-wikipedia-org-4107	2235	633	NH2	NH2	NNP
en-wikipedia-org-4107	2235	634	2C	2c	NN
en-wikipedia-org-4107	2235	635	-	-	HYPH
en-wikipedia-org-4107	2235	636	O	o	NN
en-wikipedia-org-4107	2235	637	2C	2c	JJ
en-wikipedia-org-4107	2235	638	-	-	HYPH
en-wikipedia-org-4107	2235	639	O-4	O-4	NNP
en-wikipedia-org-4107	2235	640	2C	2c	NN
en-wikipedia-org-4107	2235	641	-	-	HYPH
en-wikipedia-org-4107	2235	642	P	p	NN
en-wikipedia-org-4107	2235	643	2C	2c	NN
en-wikipedia-org-4107	2235	644	-	-	:
en-wikipedia-org-4107	2235	645	Ph	Ph	NNP
en-wikipedia-org-4107	2235	646	2C	2c	NN
en-wikipedia-org-4107	2235	647	-	-	HYPH
en-wikipedia-org-4107	2235	648	SE	se	JJ
en-wikipedia-org-4107	2235	649	2C	2c	JJ
en-wikipedia-org-4107	2235	650	-	-	HYPH
en-wikipedia-org-4107	2235	651	T	t	NN
en-wikipedia-org-4107	2235	652	2C	2c	NN
en-wikipedia-org-4107	2235	653	-	-	HYPH
en-wikipedia-org-4107	2235	654	T-2	T-2	NNP
en-wikipedia-org-4107	2235	655	2C	2c	NN
en-wikipedia-org-4107	2235	656	-	-	:
en-wikipedia-org-4107	2235	657	T-3	T-3	NNP
en-wikipedia-org-4107	2235	658	2C	2c	NN
en-wikipedia-org-4107	2235	659	-	-	HYPH
en-wikipedia-org-4107	2235	660	T-4	T-4	NNP
en-wikipedia-org-4107	2235	661	2C	2c	NN
en-wikipedia-org-4107	2235	662	-	-	:
en-wikipedia-org-4107	2235	663	T-5	T-5	NNP
en-wikipedia-org-4107	2235	664	2C	2c	CD
en-wikipedia-org-4107	2235	665	-	-	HYPH
en-wikipedia-org-4107	2235	666	T-6	T-6	NNP
en-wikipedia-org-4107	2235	667	2C	2c	NN
en-wikipedia-org-4107	2235	668	-	-	:
en-wikipedia-org-4107	2235	669	T-7	T-7	NNP
en-wikipedia-org-4107	2235	670	2C	2c	NN
en-wikipedia-org-4107	2235	671	-	-	:
en-wikipedia-org-4107	2235	672	T-8	T-8	NNP
en-wikipedia-org-4107	2235	673	2C	2c	NN
en-wikipedia-org-4107	2235	674	-	-	HYPH
en-wikipedia-org-4107	2235	675	T-9	T-9	NNP
en-wikipedia-org-4107	2235	676	2C	2c	NN
en-wikipedia-org-4107	2235	677	-	-	SYM
en-wikipedia-org-4107	2235	678	T-10	t-10	CD
en-wikipedia-org-4107	2235	679	2C	2c	CD
en-wikipedia-org-4107	2235	680	-	-	SYM
en-wikipedia-org-4107	2235	681	T-11	t-11	CD
en-wikipedia-org-4107	2235	682	2C	2c	CD
en-wikipedia-org-4107	2235	683	-	-	SYM
en-wikipedia-org-4107	2235	684	T-12	t-12	CD
en-wikipedia-org-4107	2235	685	2C	2c	CD
en-wikipedia-org-4107	2235	686	-	-	SYM
en-wikipedia-org-4107	2235	687	T-13	t-13	CD
en-wikipedia-org-4107	2235	688	2C	2c	CD
en-wikipedia-org-4107	2235	689	-	-	SYM
en-wikipedia-org-4107	2235	690	T-14	t-14	CD
en-wikipedia-org-4107	2235	691	2C	2c	CD
en-wikipedia-org-4107	2235	692	-	-	SYM
en-wikipedia-org-4107	2235	693	T-15	t-15	CD
en-wikipedia-org-4107	2235	694	2C	2c	CD
en-wikipedia-org-4107	2235	695	-	-	HYPH
en-wikipedia-org-4107	2235	696	T-16	t-16	CD
en-wikipedia-org-4107	2235	697	2C	2c	CD
en-wikipedia-org-4107	2235	698	-	-	SYM
en-wikipedia-org-4107	2235	699	T-17	t-17	CD
en-wikipedia-org-4107	2235	700	2C	2c	CD
en-wikipedia-org-4107	2235	701	-	-	SYM
en-wikipedia-org-4107	2235	702	T-18	t-18	CD
en-wikipedia-org-4107	2235	703	2C	2c	CD
en-wikipedia-org-4107	2235	704	-	-	SYM
en-wikipedia-org-4107	2235	705	T-19	t-19	CD
en-wikipedia-org-4107	2235	706	2C	2c	CD
en-wikipedia-org-4107	2235	707	-	-	SYM
en-wikipedia-org-4107	2235	708	T-20	t-20	CD
en-wikipedia-org-4107	2235	709	2C	2c	CD
en-wikipedia-org-4107	2235	710	-	-	SYM
en-wikipedia-org-4107	2235	711	T-21	t-21	CD
en-wikipedia-org-4107	2235	712	2C	2c	CD
en-wikipedia-org-4107	2235	713	-	-	HYPH
en-wikipedia-org-4107	2235	714	T-22	t-22	CD
en-wikipedia-org-4107	2235	715	2C	2C	NNP
en-wikipedia-org-4107	2235	716	-	-	HYPH
en-wikipedia-org-4107	2235	717	T-22.5	T-22.5	NNP
en-wikipedia-org-4107	2235	718	2C	2c	NN
en-wikipedia-org-4107	2235	719	-	-	SYM
en-wikipedia-org-4107	2235	720	T-23	t-23	CD
en-wikipedia-org-4107	2235	721	2C	2c	CD
en-wikipedia-org-4107	2235	722	-	-	SYM
en-wikipedia-org-4107	2235	723	T-24	t-24	CD
en-wikipedia-org-4107	2235	724	2C	2c	CD
en-wikipedia-org-4107	2235	725	-	-	SYM
en-wikipedia-org-4107	2235	726	T-25	t-25	CD
en-wikipedia-org-4107	2235	727	2C	2c	CD
en-wikipedia-org-4107	2235	728	-	-	SYM
en-wikipedia-org-4107	2235	729	T-27	t-27	CD
en-wikipedia-org-4107	2235	730	2C	2c	CD
en-wikipedia-org-4107	2235	731	-	-	HYPH
en-wikipedia-org-4107	2235	732	T-28	t-28	CD
en-wikipedia-org-4107	2235	733	2C	2c	CD
en-wikipedia-org-4107	2235	734	-	-	SYM
en-wikipedia-org-4107	2235	735	T-30	t-30	CD
en-wikipedia-org-4107	2235	736	2C	2c	CD
en-wikipedia-org-4107	2235	737	-	-	SYM
en-wikipedia-org-4107	2235	738	T-31	t-31	CD
en-wikipedia-org-4107	2235	739	2C	2c	CD
en-wikipedia-org-4107	2235	740	-	-	SYM
en-wikipedia-org-4107	2235	741	T-32	t-32	CD
en-wikipedia-org-4107	2235	742	2C	2c	CD
en-wikipedia-org-4107	2235	743	-	-	SYM
en-wikipedia-org-4107	2235	744	T-33	t-33	CD
en-wikipedia-org-4107	2235	745	2C	2c	NN
en-wikipedia-org-4107	2235	746	-	-	HYPH
en-wikipedia-org-4107	2235	747	TFE	tfe	NN
en-wikipedia-org-4107	2235	748	2C	2c	NN
en-wikipedia-org-4107	2235	749	-	-	HYPH
en-wikipedia-org-4107	2235	750	TFM	tfm	NN
en-wikipedia-org-4107	2235	751	2C	2c	NN
en-wikipedia-org-4107	2235	752	-	-	HYPH
en-wikipedia-org-4107	2235	753	YN	YN	NNP
en-wikipedia-org-4107	2235	754	2C	2c	NN
en-wikipedia-org-4107	2235	755	-	-	HYPH
en-wikipedia-org-4107	2235	756	V	v	NN
en-wikipedia-org-4107	2235	757	Allylescaline	allylescaline	NN
en-wikipedia-org-4107	2235	758	DESOXY	DESOXY	NNP
en-wikipedia-org-4107	2235	759	Escaline	Escaline	NNP
en-wikipedia-org-4107	2235	760	Isoproscaline	Isoproscaline	NNP
en-wikipedia-org-4107	2235	761	Jimscaline	Jimscaline	NNP
en-wikipedia-org-4107	2235	762	Macromerine	Macromerine	NNP
en-wikipedia-org-4107	2235	763	MEPEA	MEPEA	NNP
en-wikipedia-org-4107	2235	764	Mescaline	Mescaline	NNP
en-wikipedia-org-4107	2235	765	Metaescaline	Metaescaline	NNP
en-wikipedia-org-4107	2235	766	Methallylescaline	Methallylescaline	NNP
en-wikipedia-org-4107	2235	767	Proscaline	Proscaline	NNP
en-wikipedia-org-4107	2235	768	Psi-2C	Psi-2C	NNP
en-wikipedia-org-4107	2235	769	-	-	HYPH
en-wikipedia-org-4107	2235	770	T-4	T-4	NNP
en-wikipedia-org-4107	2235	771	TCB-2	TCB-2	NNP
en-wikipedia-org-4107	2235	772	Venlafaxine	Venlafaxine	NNP
en-wikipedia-org-4107	2235	773	Stimulants	Stimulants	NNP
en-wikipedia-org-4107	2235	774	:	:	:
en-wikipedia-org-4107	2235	775	Phenylethanolamine	Phenylethanolamine	NNP
en-wikipedia-org-4107	2235	776	Hordenine	Hordenine	NNP
en-wikipedia-org-4107	2235	777	Phenethylamine	Phenethylamine	NNP
en-wikipedia-org-4107	2235	778	α	α	NNP
en-wikipedia-org-4107	2235	779	-	-	:
en-wikipedia-org-4107	2235	780	Methylphenethylamine	Methylphenethylamine	NNP
en-wikipedia-org-4107	2235	781	(	(	-LRB-
en-wikipedia-org-4107	2235	782	amphetamine	amphetamine	NN
en-wikipedia-org-4107	2235	783	)	)	-RRB-
en-wikipedia-org-4107	2235	784	β	β	NNP
en-wikipedia-org-4107	2235	785	-	-	HYPH
en-wikipedia-org-4107	2235	786	Methylphenethylamine	Methylphenethylamine	NNP
en-wikipedia-org-4107	2235	787	m	m	NNP
en-wikipedia-org-4107	2235	788	-	-	HYPH
en-wikipedia-org-4107	2235	789	Methylphenethylamine	Methylphenethylamine	NNP
en-wikipedia-org-4107	2235	790	N	N	NNP
en-wikipedia-org-4107	2235	791	-	-	HYPH
en-wikipedia-org-4107	2235	792	Methylphenethylamine	Methylphenethylamine	NNP
en-wikipedia-org-4107	2235	793	o	o	NNP
en-wikipedia-org-4107	2235	794	-	-	HYPH
en-wikipedia-org-4107	2235	795	Methylphenethylamine	Methylphenethylamine	NNP
en-wikipedia-org-4107	2235	796	p	p	NNP
en-wikipedia-org-4107	2235	797	-	-	HYPH
en-wikipedia-org-4107	2235	798	Methylphenethylamine	Methylphenethylamine	NNP
en-wikipedia-org-4107	2235	799	Methylphenidate	Methylphenidate	NNP
en-wikipedia-org-4107	2235	800	Entactogens	Entactogens	NNPS
en-wikipedia-org-4107	2235	801	:	:	:
en-wikipedia-org-4107	2235	802	Lophophine	lophophine	JJ
en-wikipedia-org-4107	2235	803	MDPEA	mdpea	NN
en-wikipedia-org-4107	2235	804	MDMPEA	mdmpea	RB
en-wikipedia-org-4107	2235	805	Others	other	NNS
en-wikipedia-org-4107	2235	806	:	:	:
en-wikipedia-org-4107	2235	807	BOH	BOH	NNP
en-wikipedia-org-4107	2235	808	DMPEA	DMPEA	NNP
en-wikipedia-org-4107	2235	809	Amphetamines	Amphetamines	NNPS
en-wikipedia-org-4107	2235	810	Psychedelics	Psychedelics	NNPS
en-wikipedia-org-4107	2235	811	:	:	:
en-wikipedia-org-4107	2235	812	3C	3c	NN
en-wikipedia-org-4107	2235	813	-	-	HYPH
en-wikipedia-org-4107	2235	814	BZ	bz	JJ
en-wikipedia-org-4107	2235	815	3C	3c	NN
en-wikipedia-org-4107	2235	816	-	-	HYPH
en-wikipedia-org-4107	2235	817	E	e	NN
en-wikipedia-org-4107	2235	818	3C	3c	NN
en-wikipedia-org-4107	2235	819	-	-	HYPH
en-wikipedia-org-4107	2235	820	P	p	NN
en-wikipedia-org-4107	2235	821	Aleph	Aleph	NNP
en-wikipedia-org-4107	2235	822	Beatrice	Beatrice	NNP
en-wikipedia-org-4107	2235	823	Bromo	Bromo	NNP
en-wikipedia-org-4107	2235	824	-	-	HYPH
en-wikipedia-org-4107	2235	825	DragonFLY	DragonFLY	NNP
en-wikipedia-org-4107	2235	826	D	D	NNP
en-wikipedia-org-4107	2235	827	-	-	HYPH
en-wikipedia-org-4107	2235	828	Deprenyl	Deprenyl	NNP
en-wikipedia-org-4107	2235	829	DMA	DMA	NNP
en-wikipedia-org-4107	2235	830	DMCPA	DMCPA	NNP
en-wikipedia-org-4107	2235	831	DMMDA	DMMDA	NNP
en-wikipedia-org-4107	2235	832	DOB	DOB	NNP
en-wikipedia-org-4107	2235	833	DOC	DOC	NNP
en-wikipedia-org-4107	2235	834	DOEF	DOEF	NNP
en-wikipedia-org-4107	2235	835	DOET	DOET	NNP
en-wikipedia-org-4107	2235	836	DOI	DOI	NNP
en-wikipedia-org-4107	2235	837	DOM	DOM	NNP
en-wikipedia-org-4107	2235	838	DON	DON	NNP
en-wikipedia-org-4107	2235	839	DOPR	DOPR	NNP
en-wikipedia-org-4107	2235	840	DOTFM	DOTFM	NNP
en-wikipedia-org-4107	2235	841	Ganesha	Ganesha	NNP
en-wikipedia-org-4107	2235	842	MMDA	MMDA	NNP
en-wikipedia-org-4107	2235	843	MMDA-2	mmda-2	VB
en-wikipedia-org-4107	2235	844	Psi	Psi	NNP
en-wikipedia-org-4107	2235	845	-	-	HYPH
en-wikipedia-org-4107	2235	846	DOM	DOM	NNP
en-wikipedia-org-4107	2235	847	TMA	TMA	NNP
en-wikipedia-org-4107	2235	848	TeMA	TeMA	NNP
en-wikipedia-org-4107	2235	849	Stimulants	stimulant	NNS
en-wikipedia-org-4107	2235	850	:	:	:
en-wikipedia-org-4107	2235	851	2-FA	2-fa	CD
en-wikipedia-org-4107	2235	852	2-FMA	2-fma	CD
en-wikipedia-org-4107	2235	853	3-FA	3-fa	CD
en-wikipedia-org-4107	2235	854	3-FMA	3-fma	CD
en-wikipedia-org-4107	2235	855	Acridorex	Acridorex	NNP
en-wikipedia-org-4107	2235	856	Alfetamine	Alfetamine	NNP
en-wikipedia-org-4107	2235	857	Amfecloral	amfecloral	JJ
en-wikipedia-org-4107	2235	858	Amfepentorex	Amfepentorex	NNP
en-wikipedia-org-4107	2235	859	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2235	860	(	(	-LRB-
en-wikipedia-org-4107	2235	861	Dextroamphetamine	Dextroamphetamine	NNP
en-wikipedia-org-4107	2235	862	,	,	,
en-wikipedia-org-4107	2235	863	Levoamphetamine	Levoamphetamine	NNP
en-wikipedia-org-4107	2235	864	)	)	-RRB-
en-wikipedia-org-4107	2235	865	Amphetaminil	Amphetaminil	NNP
en-wikipedia-org-4107	2235	866	Benfluorex	Benfluorex	NNP
en-wikipedia-org-4107	2235	867	Benzphetamine	Benzphetamine	NNP
en-wikipedia-org-4107	2235	868	Cathine	Cathine	NNP
en-wikipedia-org-4107	2235	869	Clobenzorex	Clobenzorex	NNP
en-wikipedia-org-4107	2235	870	Dimethylamphetamine	Dimethylamphetamine	NNP
en-wikipedia-org-4107	2235	871	Ephedrine	Ephedrine	NNP
en-wikipedia-org-4107	2235	872	Etilamfetamine	Etilamfetamine	NNP
en-wikipedia-org-4107	2235	873	Fencamfamin	Fencamfamin	NNP
en-wikipedia-org-4107	2235	874	Fencamine	Fencamine	NNP
en-wikipedia-org-4107	2235	875	Fenethylline	Fenethylline	NNP
en-wikipedia-org-4107	2235	876	Fenfluramine	Fenfluramine	NNP
en-wikipedia-org-4107	2235	877	(	(	-LRB-
en-wikipedia-org-4107	2235	878	Dexfenfluramine	Dexfenfluramine	NNP
en-wikipedia-org-4107	2235	879	,	,	,
en-wikipedia-org-4107	2235	880	Levofenfluramine	Levofenfluramine	NNP
en-wikipedia-org-4107	2235	881	)	)	-RRB-
en-wikipedia-org-4107	2235	882	Fenproporex	Fenproporex	NNP
en-wikipedia-org-4107	2235	883	Flucetorex	Flucetorex	NNP
en-wikipedia-org-4107	2235	884	Fludorex	Fludorex	NNP
en-wikipedia-org-4107	2235	885	Formetorex	Formetorex	NNP
en-wikipedia-org-4107	2235	886	Furfenorex	Furfenorex	NNP
en-wikipedia-org-4107	2235	887	Gepefrine	Gepefrine	NNP
en-wikipedia-org-4107	2235	888	4-Hydroxyamphetamine	4-hydroxyamphetamine	CD
en-wikipedia-org-4107	2235	889	Iofetamine	Iofetamine	NNP
en-wikipedia-org-4107	2235	890	Isopropylamphetamine	Isopropylamphetamine	NNP
en-wikipedia-org-4107	2235	891	Lefetamine	Lefetamine	NNP
en-wikipedia-org-4107	2235	892	Lisdexamfetamine	Lisdexamfetamine	NNP
en-wikipedia-org-4107	2235	893	Mefenorex	Mefenorex	NNP
en-wikipedia-org-4107	2235	894	Metaraminol	Metaraminol	NNP
en-wikipedia-org-4107	2235	895	Methamphetamine	Methamphetamine	NNP
en-wikipedia-org-4107	2235	896	(	(	-LRB-
en-wikipedia-org-4107	2235	897	Dextromethamphetamine	Dextromethamphetamine	NNP
en-wikipedia-org-4107	2235	898	,	,	,
en-wikipedia-org-4107	2235	899	Levomethamphetamine	Levomethamphetamine	NNP
en-wikipedia-org-4107	2235	900	)	)	-RRB-
en-wikipedia-org-4107	2235	901	Methoxyphenamine	Methoxyphenamine	NNP
en-wikipedia-org-4107	2235	902	MMA	MMA	NNP
en-wikipedia-org-4107	2235	903	Morforex	Morforex	NNP
en-wikipedia-org-4107	2235	904	Norfenfluramine	Norfenfluramine	NNP
en-wikipedia-org-4107	2235	905	L	L	NNP
en-wikipedia-org-4107	2235	906	-Norpseudoephedrine	-Norpseudoephedrine	NNP
en-wikipedia-org-4107	2235	907	N	n	NN
en-wikipedia-org-4107	2235	908	,	,	,
en-wikipedia-org-4107	2235	909	alpha	alpha	NN
en-wikipedia-org-4107	2235	910	-	-	:
en-wikipedia-org-4107	2235	911	Diethylphenylethylamine	Diethylphenylethylamine	NNP
en-wikipedia-org-4107	2235	912	Oxifentorex	Oxifentorex	NNP
en-wikipedia-org-4107	2235	913	Oxilofrine	Oxilofrine	NNP
en-wikipedia-org-4107	2235	914	Ortetamine	Ortetamine	NNP
en-wikipedia-org-4107	2235	915	PBA	PBA	NNP
en-wikipedia-org-4107	2235	916	PCA	PCA	NNP
en-wikipedia-org-4107	2235	917	Phenpromethamine	Phenpromethamine	NNP
en-wikipedia-org-4107	2235	918	PFA	PFA	NNP
en-wikipedia-org-4107	2235	919	PFMA	PFMA	VBD
en-wikipedia-org-4107	2235	920	PIA	PIA	NNP
en-wikipedia-org-4107	2235	921	PMA	PMA	NNP
en-wikipedia-org-4107	2235	922	PMEA	PMEA	VBN
en-wikipedia-org-4107	2235	923	PMMA	pmma	NN
en-wikipedia-org-4107	2235	924	Phenylpropanolamine	Phenylpropanolamine	NNP
en-wikipedia-org-4107	2235	925	Pholedrine	Pholedrine	NNP
en-wikipedia-org-4107	2235	926	Prenylamine	Prenylamine	NNP
en-wikipedia-org-4107	2235	927	Propylamphetamine	Propylamphetamine	NNP
en-wikipedia-org-4107	2235	928	Pseudoephedrine	Pseudoephedrine	NNP
en-wikipedia-org-4107	2235	929	Sibutramine	Sibutramine	NNP
en-wikipedia-org-4107	2235	930	Tiflorex	Tiflorex	NNP
en-wikipedia-org-4107	2235	931	Tranylcypromine	Tranylcypromine	NNP
en-wikipedia-org-4107	2235	932	Xylopropamine	Xylopropamine	NNP
en-wikipedia-org-4107	2235	933	Zylofuramine	Zylofuramine	NNP
en-wikipedia-org-4107	2235	934	Entactogens	Entactogens	NNP
en-wikipedia-org-4107	2235	935	:	:	:
en-wikipedia-org-4107	2235	936	4-FA	4-fa	CD
en-wikipedia-org-4107	2235	937	4-FMA	4-fma	CD
en-wikipedia-org-4107	2235	938	4-MA	4-ma	CD
en-wikipedia-org-4107	2235	939	4-MMA	4-mma	CD
en-wikipedia-org-4107	2235	940	4-MTA	4-MTA	NNP
en-wikipedia-org-4107	2235	941	5-APB	5-APB	NNP
en-wikipedia-org-4107	2235	942	5-APDB	5-APDB	NNP
en-wikipedia-org-4107	2235	943	5-EAPB	5-EAPB	NNP
en-wikipedia-org-4107	2235	944	5-IT	5-it	CD
en-wikipedia-org-4107	2235	945	5-MAPB	5-mapb	RB
en-wikipedia-org-4107	2235	946	5-MAPDB	5-MAPDB	NNP
en-wikipedia-org-4107	2235	947	6-APB	6-APB	NNP
en-wikipedia-org-4107	2235	948	6-APDB	6-APDB	NNP
en-wikipedia-org-4107	2235	949	6-Chloro	6-chloro	CD
en-wikipedia-org-4107	2235	950	-	-	HYPH
en-wikipedia-org-4107	2235	951	MDMA	mdma	NN
en-wikipedia-org-4107	2235	952	6-EAPB	6-eapb	NN
en-wikipedia-org-4107	2235	953	6-IT	6-it	CD
en-wikipedia-org-4107	2235	954	6-MAPB	6-mapb	NN
en-wikipedia-org-4107	2235	955	6-MAPDB	6-mapdb	NN
en-wikipedia-org-4107	2235	956	EDA	EDA	NNP
en-wikipedia-org-4107	2235	957	IAP	IAP	NNP
en-wikipedia-org-4107	2235	958	2,3-MDA	2,3-mda	NN
en-wikipedia-org-4107	2235	959	3,4-MDA	3,4-mda	NN
en-wikipedia-org-4107	2235	960	(	(	-LRB-
en-wikipedia-org-4107	2235	961	tenamfetamine	tenamfetamine	NN
en-wikipedia-org-4107	2235	962	)	)	-RRB-
en-wikipedia-org-4107	2235	963	MDEA	MDEA	NNP
en-wikipedia-org-4107	2235	964	MDHMA	MDHMA	NNP
en-wikipedia-org-4107	2235	965	MDMA	MDMA	NNP
en-wikipedia-org-4107	2235	966	(	(	-LRB-
en-wikipedia-org-4107	2235	967	midomafetamine	midomafetamine	NN
en-wikipedia-org-4107	2235	968	)	)	-RRB-
en-wikipedia-org-4107	2235	969	MDOH	MDOH	NNP
en-wikipedia-org-4107	2235	970	Methamnetamine	Methamnetamine	NNP
en-wikipedia-org-4107	2235	971	MMDMA	mmdma	NN
en-wikipedia-org-4107	2235	972	Naphthylaminopropane	Naphthylaminopropane	NNP
en-wikipedia-org-4107	2235	973	TAP	TAP	NNP
en-wikipedia-org-4107	2235	974	Others	Others	NNPS
en-wikipedia-org-4107	2235	975	:	:	:
en-wikipedia-org-4107	2235	976	3,4-DCA	3,4-dca	CD
en-wikipedia-org-4107	2235	977	Amiflamine	amiflamine	NN
en-wikipedia-org-4107	2235	978	DiFMDA	DiFMDA	NNP
en-wikipedia-org-4107	2235	979	Selegiline	Selegiline	NNP
en-wikipedia-org-4107	2235	980	(	(	-LRB-
en-wikipedia-org-4107	2235	981	also	also	RB
en-wikipedia-org-4107	2235	982	D	D	NNP
en-wikipedia-org-4107	2235	983	-Deprenyl	-Deprenyl	NNP
en-wikipedia-org-4107	2235	984	)	)	-RRB-
en-wikipedia-org-4107	2235	985	Phentermines	Phentermines	NNP
en-wikipedia-org-4107	2235	986	Stimulants	Stimulants	NNP
en-wikipedia-org-4107	2235	987	:	:	:
en-wikipedia-org-4107	2235	988	Chlorphentermine	Chlorphentermine	NNP
en-wikipedia-org-4107	2235	989	Cloforex	Cloforex	NNP
en-wikipedia-org-4107	2235	990	Clortermine	Clortermine	NNP
en-wikipedia-org-4107	2235	991	Etolorex	Etolorex	NNP
en-wikipedia-org-4107	2235	992	Mephentermine	Mephentermine	NNP
en-wikipedia-org-4107	2235	993	Pentorex	Pentorex	NNP
en-wikipedia-org-4107	2235	994	Phentermine	Phentermine	NNP
en-wikipedia-org-4107	2235	995	Entactogens	Entactogens	NNPS
en-wikipedia-org-4107	2235	996	:	:	:
en-wikipedia-org-4107	2235	997	MDPH	MDPH	NNP
en-wikipedia-org-4107	2235	998	MDMPH	MDMPH	NNP
en-wikipedia-org-4107	2235	999	Others	Others	NNPS
en-wikipedia-org-4107	2235	1000	:	:	:
en-wikipedia-org-4107	2235	1001	Cericlamine	Cericlamine	NNP
en-wikipedia-org-4107	2235	1002	Cathinones	Cathinones	NNPS
en-wikipedia-org-4107	2235	1003	Stimulants	Stimulants	NNPS
en-wikipedia-org-4107	2235	1004	:	:	:
en-wikipedia-org-4107	2235	1005	3-FMC	3-fmc	CD
en-wikipedia-org-4107	2235	1006	4-MC	4-mc	CD
en-wikipedia-org-4107	2235	1007	4-BMC	4-bmc	CD
en-wikipedia-org-4107	2235	1008	4-CMC	4-cmc	CD
en-wikipedia-org-4107	2235	1009	4-EMC	4-emc	CD
en-wikipedia-org-4107	2235	1010	4-FMC	4-fmc	CD
en-wikipedia-org-4107	2235	1011	4-MEC	4-mec	CD
en-wikipedia-org-4107	2235	1012	4-MeMABP	4-memabp	CD
en-wikipedia-org-4107	2235	1013	4-MPD	4-mpd	CD
en-wikipedia-org-4107	2235	1014	Amfepramone	Amfepramone	NNP
en-wikipedia-org-4107	2235	1015	Benzedrone	Benzedrone	NNP
en-wikipedia-org-4107	2235	1016	Brephedrone	Brephedrone	NNP
en-wikipedia-org-4107	2235	1017	Buphedrone	Buphedrone	NNP
en-wikipedia-org-4107	2235	1018	Bupropion	Bupropion	NNP
en-wikipedia-org-4107	2235	1019	Cathinone	Cathinone	NNP
en-wikipedia-org-4107	2235	1020	Dimethylcathinone	Dimethylcathinone	NNP
en-wikipedia-org-4107	2235	1021	Ethcathinone	ethcathinone	VB
en-wikipedia-org-4107	2235	1022	Eutylone	Eutylone	VBD
en-wikipedia-org-4107	2235	1023	Hydroxybupropion	hydroxybupropion	NN
en-wikipedia-org-4107	2235	1024	Methcathinone	Methcathinone	NNP
en-wikipedia-org-4107	2235	1025	Methedrone	Methedrone	NNP
en-wikipedia-org-4107	2235	1026	NEB	NEB	NNP
en-wikipedia-org-4107	2235	1027	N	N	NNP
en-wikipedia-org-4107	2235	1028	-	-	HYPH
en-wikipedia-org-4107	2235	1029	Ethylhexedrone	Ethylhexedrone	NNP
en-wikipedia-org-4107	2235	1030	N	N	NNP
en-wikipedia-org-4107	2235	1031	-	-	HYPH
en-wikipedia-org-4107	2235	1032	Ethylpentedrone	Ethylpentedrone	NNP
en-wikipedia-org-4107	2235	1033	Pentedrone	Pentedrone	NNP
en-wikipedia-org-4107	2235	1034	Pentylone	Pentylone	NNP
en-wikipedia-org-4107	2235	1035	Radafaxine	Radafaxine	NNP
en-wikipedia-org-4107	2235	1036	Entactogens	Entactogens	NNPS
en-wikipedia-org-4107	2235	1037	:	:	:
en-wikipedia-org-4107	2235	1038	3,4-DMMC	3,4-dmmc	CD
en-wikipedia-org-4107	2235	1039	3-MMC	3-mmc	CD
en-wikipedia-org-4107	2235	1040	Butylone	Butylone	NNP
en-wikipedia-org-4107	2235	1041	Ethylone	Ethylone	NNP
en-wikipedia-org-4107	2235	1042	Methylone	Methylone	NNP
en-wikipedia-org-4107	2235	1043	Methylenedioxycathinone	Methylenedioxycathinone	NNP
en-wikipedia-org-4107	2235	1044	Mephedrone	Mephedrone	NNP
en-wikipedia-org-4107	2235	1045	Phenylisobutylamines	Phenylisobutylamines	NNP
en-wikipedia-org-4107	2235	1046	Entactogens	Entactogens	NNPS
en-wikipedia-org-4107	2235	1047	:	:	:
en-wikipedia-org-4107	2235	1048	4-CAB	4-cab	CD
en-wikipedia-org-4107	2235	1049	4-MAB	4-mab	CD
en-wikipedia-org-4107	2235	1050	Ariadne	Ariadne	VBZ
en-wikipedia-org-4107	2235	1051	BDB	BDB	NNP
en-wikipedia-org-4107	2235	1052	Butylone	Butylone	NNP
en-wikipedia-org-4107	2235	1053	EBDB	EBDB	NNP
en-wikipedia-org-4107	2235	1054	Eutylone	Eutylone	NNP
en-wikipedia-org-4107	2235	1055	MBDB	MBDB	NNP
en-wikipedia-org-4107	2235	1056	Stimulants	Stimulants	NNPS
en-wikipedia-org-4107	2235	1057	:	:	:
en-wikipedia-org-4107	2235	1058	Phenylisobutylamine	Phenylisobutylamine	NNP
en-wikipedia-org-4107	2235	1059	Phenylalkylpyrrolidines	Phenylalkylpyrrolidines	NNP
en-wikipedia-org-4107	2235	1060	Stimulants	Stimulants	NNPS
en-wikipedia-org-4107	2235	1061	:	:	:
en-wikipedia-org-4107	2235	1062	α	α	LS
en-wikipedia-org-4107	2235	1063	-	-	HYPH
en-wikipedia-org-4107	2235	1064	PBP	PBP	NNP
en-wikipedia-org-4107	2235	1065	α	α	NNP
en-wikipedia-org-4107	2235	1066	-	-	HYPH
en-wikipedia-org-4107	2235	1067	PHP	PHP	NNP
en-wikipedia-org-4107	2235	1068	α	α	NNP
en-wikipedia-org-4107	2235	1069	-	-	HYPH
en-wikipedia-org-4107	2235	1070	PPP	PPP	NNP
en-wikipedia-org-4107	2235	1071	α	α	NNP
en-wikipedia-org-4107	2235	1072	-	-	HYPH
en-wikipedia-org-4107	2235	1073	PVP	PVP	NNP
en-wikipedia-org-4107	2235	1074	MDPBP	MDPBP	NNP
en-wikipedia-org-4107	2235	1075	MDPPP	MDPPP	NNP
en-wikipedia-org-4107	2235	1076	MDPV	MDPV	NNP
en-wikipedia-org-4107	2235	1077	4-MePBP	4-mepbp	NN
en-wikipedia-org-4107	2235	1078	4-MePHP	4-mephp	NN
en-wikipedia-org-4107	2235	1079	4-MePPP	4-meppp	NN
en-wikipedia-org-4107	2235	1080	MOPPP	MOPPP	NNP
en-wikipedia-org-4107	2235	1081	MOPVP	MOPVP	NNP
en-wikipedia-org-4107	2235	1082	MPBP	mpbp	JJ
en-wikipedia-org-4107	2235	1083	MPHP	mphp	NN
en-wikipedia-org-4107	2235	1084	MPPP	MPPP	NNP
en-wikipedia-org-4107	2235	1085	Naphyrone	Naphyrone	NNP
en-wikipedia-org-4107	2235	1086	PEP	PEP	NNP
en-wikipedia-org-4107	2235	1087	Prolintane	Prolintane	NNP
en-wikipedia-org-4107	2235	1088	Pyrovalerone	Pyrovalerone	NNP
en-wikipedia-org-4107	2235	1089	Catecholamines	Catecholamines	NNP
en-wikipedia-org-4107	2235	1090	(	(	-LRB-
en-wikipedia-org-4107	2235	1091	and	and	CC
en-wikipedia-org-4107	2235	1092	close	close	JJ
en-wikipedia-org-4107	2235	1093	relatives	relative	NNS
en-wikipedia-org-4107	2235	1094	)	)	-RRB-
en-wikipedia-org-4107	2235	1095	6-FNE	6-fne	CD
en-wikipedia-org-4107	2235	1096	6-OHDA	6-ohda	NN
en-wikipedia-org-4107	2235	1097	a	a	DT
en-wikipedia-org-4107	2235	1098	-	-	HYPH
en-wikipedia-org-4107	2235	1099	Me	Me	NNP
en-wikipedia-org-4107	2235	1100	-	-	HYPH
en-wikipedia-org-4107	2235	1101	DA	DA	NNP
en-wikipedia-org-4107	2235	1102	a	a	DT
en-wikipedia-org-4107	2235	1103	-	-	HYPH
en-wikipedia-org-4107	2235	1104	Me	Me	NNP
en-wikipedia-org-4107	2235	1105	-	-	HYPH
en-wikipedia-org-4107	2235	1106	TRA	TRA	NNP
en-wikipedia-org-4107	2235	1107	Adrenochrome	Adrenochrome	NNP
en-wikipedia-org-4107	2235	1108	Ciladopa	ciladopa	NN
en-wikipedia-org-4107	2235	1109	D	d	NN
en-wikipedia-org-4107	2235	1110	-DOPA	-DOPA	.
en-wikipedia-org-4107	2235	1111	(	(	-LRB-
en-wikipedia-org-4107	2235	1112	Dextrodopa	Dextrodopa	NNP
en-wikipedia-org-4107	2235	1113	)	)	-RRB-
en-wikipedia-org-4107	2235	1114	Dimetofrine	Dimetofrine	NNP
en-wikipedia-org-4107	2235	1115	Dopamine	Dopamine	NNP
en-wikipedia-org-4107	2235	1116	Epinephrine	Epinephrine	NNP
en-wikipedia-org-4107	2235	1117	Epinine	Epinine	NNP
en-wikipedia-org-4107	2235	1118	Etilefrine	Etilefrine	NNP
en-wikipedia-org-4107	2235	1119	Ethylnorepinephrine	Ethylnorepinephrine	NNP
en-wikipedia-org-4107	2235	1120	Fenclonine	Fenclonine	NNP
en-wikipedia-org-4107	2235	1121	Ibopamine	Ibopamine	NNP
en-wikipedia-org-4107	2235	1122	Isoprenaline	Isoprenaline	NNP
en-wikipedia-org-4107	2235	1123	Isoetarine	Isoetarine	NNP
en-wikipedia-org-4107	2235	1124	L	L	NNP
en-wikipedia-org-4107	2235	1125	-DOPA	-DOPA	:
en-wikipedia-org-4107	2235	1126	(	(	-LRB-
en-wikipedia-org-4107	2235	1127	Levodopa	Levodopa	NNP
en-wikipedia-org-4107	2235	1128	)	)	-RRB-
en-wikipedia-org-4107	2235	1129	L	L	NNP
en-wikipedia-org-4107	2235	1130	-DOPS	-DOPS	.
en-wikipedia-org-4107	2235	1131	(	(	-LRB-
en-wikipedia-org-4107	2235	1132	Droxidopa	Droxidopa	NNP
en-wikipedia-org-4107	2235	1133	)	)	-RRB-
en-wikipedia-org-4107	2235	1134	L	L	NNP
en-wikipedia-org-4107	2235	1135	-Phenylalanine	-Phenylalanine	NNP
en-wikipedia-org-4107	2235	1136	L	L	NNP
en-wikipedia-org-4107	2235	1137	-Tyrosine	-Tyrosine	HYPH
en-wikipedia-org-4107	2235	1138	m	m	NNP
en-wikipedia-org-4107	2235	1139	-	-	HYPH
en-wikipedia-org-4107	2235	1140	Tyramine	Tyramine	NNP
en-wikipedia-org-4107	2235	1141	Metanephrine	Metanephrine	NNP
en-wikipedia-org-4107	2235	1142	Metaraminol	Metaraminol	NNP
en-wikipedia-org-4107	2235	1143	Metaterol	Metaterol	NNP
en-wikipedia-org-4107	2235	1144	Metirosine	Metirosine	NNP
en-wikipedia-org-4107	2235	1145	Methyldopa	Methyldopa	NNP
en-wikipedia-org-4107	2235	1146	N	N	NNP
en-wikipedia-org-4107	2235	1147	,	,	,
en-wikipedia-org-4107	2235	1148	N	N	NNP
en-wikipedia-org-4107	2235	1149	-	-	HYPH
en-wikipedia-org-4107	2235	1150	Dimethyldopamine	Dimethyldopamine	NNP
en-wikipedia-org-4107	2235	1151	Nordefrin	Nordefrin	NNP
en-wikipedia-org-4107	2235	1152	(	(	-LRB-
en-wikipedia-org-4107	2235	1153	Levonordefrin	Levonordefrin	NNP
en-wikipedia-org-4107	2235	1154	)	)	-RRB-
en-wikipedia-org-4107	2235	1155	Norepinephrine	Norepinephrine	NNP
en-wikipedia-org-4107	2235	1156	Norfenefrine	Norfenefrine	NNP
en-wikipedia-org-4107	2235	1157	(	(	-LRB-
en-wikipedia-org-4107	2235	1158	m	m	NNP
en-wikipedia-org-4107	2235	1159	-	-	HYPH
en-wikipedia-org-4107	2235	1160	Octopamine	Octopamine	NNP
en-wikipedia-org-4107	2235	1161	)	)	-RRB-
en-wikipedia-org-4107	2235	1162	Normetanephrine	Normetanephrine	NNP
en-wikipedia-org-4107	2235	1163	Orciprenaline	Orciprenaline	NNP
en-wikipedia-org-4107	2235	1164	p	p	NNP
en-wikipedia-org-4107	2235	1165	-	-	:
en-wikipedia-org-4107	2235	1166	Octopamine	Octopamine	NNP
en-wikipedia-org-4107	2235	1167	p	p	NN
en-wikipedia-org-4107	2235	1168	-	-	HYPH
en-wikipedia-org-4107	2235	1169	Tyramine	Tyramine	NNP
en-wikipedia-org-4107	2235	1170	Phenylephrine	phenylephrine	JJ
en-wikipedia-org-4107	2235	1171	Synephrine	Synephrine	NNP
en-wikipedia-org-4107	2235	1172	Miscellaneous	miscellaneous	JJ
en-wikipedia-org-4107	2235	1173	AL	AL	NNP
en-wikipedia-org-4107	2235	1174	-	-	HYPH
en-wikipedia-org-4107	2235	1175	LAD	LAD	NNP
en-wikipedia-org-4107	2235	1176	Amidephrine	Amidephrine	NNP
en-wikipedia-org-4107	2235	1177	Arbutamine	arbutamine	JJ
en-wikipedia-org-4107	2235	1178	Cafedrine	cafedrine	NN
en-wikipedia-org-4107	2235	1179	Denopamine	denopamine	NN
en-wikipedia-org-4107	2235	1180	Desvenlafaxine	Desvenlafaxine	NNP
en-wikipedia-org-4107	2235	1181	Diphenidine	Diphenidine	NNP
en-wikipedia-org-4107	2235	1182	Dizocilpine	Dizocilpine	NNP
en-wikipedia-org-4107	2235	1183	Dobutamine	Dobutamine	NNP
en-wikipedia-org-4107	2235	1184	Dopexamine	Dopexamine	NNP
en-wikipedia-org-4107	2235	1185	Ephenidine	Ephenidine	NNP
en-wikipedia-org-4107	2235	1186	Etafedrine	Etafedrine	NNP
en-wikipedia-org-4107	2235	1187	ETH	ETH	NNP
en-wikipedia-org-4107	2235	1188	-	-	HYPH
en-wikipedia-org-4107	2235	1189	LAD	LAD	NNP
en-wikipedia-org-4107	2235	1190	Famprofazone	Famprofazone	NNP
en-wikipedia-org-4107	2235	1191	Fluorolintane	Fluorolintane	NNP
en-wikipedia-org-4107	2235	1192	Hexapradol	Hexapradol	NNP
en-wikipedia-org-4107	2235	1193	IP	IP	NNP
en-wikipedia-org-4107	2235	1194	-	-	HYPH
en-wikipedia-org-4107	2235	1195	LAD	LAD	NNP
en-wikipedia-org-4107	2235	1196	Lysergic	lysergic	JJ
en-wikipedia-org-4107	2235	1197	acid	acid	NN
en-wikipedia-org-4107	2235	1198	amide	amide	IN
en-wikipedia-org-4107	2235	1199	Lysergic	Lysergic	NNP
en-wikipedia-org-4107	2235	1200	acid	acid	NN
en-wikipedia-org-4107	2235	1201	2-butyl	2-butyl	CD
en-wikipedia-org-4107	2235	1202	amide	amide	NN
en-wikipedia-org-4107	2235	1203	Lysergic	lysergic	JJ
en-wikipedia-org-4107	2235	1204	acid	acid	NN
en-wikipedia-org-4107	2235	1205	2,4-dimethylazetidide	2,4-dimethylazetidide	CD
en-wikipedia-org-4107	2235	1206	Lysergic	lysergic	JJ
en-wikipedia-org-4107	2235	1207	acid	acid	NN
en-wikipedia-org-4107	2235	1208	diethylamide	diethylamide	NN
en-wikipedia-org-4107	2235	1209	Methoxamine	Methoxamine	NNP
en-wikipedia-org-4107	2235	1210	Methoxphenidine	Methoxphenidine	NNP
en-wikipedia-org-4107	2235	1211	MT-45	MT-45	NNP
en-wikipedia-org-4107	2235	1212	PARGY	PARGY	NNP
en-wikipedia-org-4107	2235	1213	-	-	HYPH
en-wikipedia-org-4107	2235	1214	LAD	lad	NN
en-wikipedia-org-4107	2235	1215	Phenibut	Phenibut	NNP
en-wikipedia-org-4107	2235	1216	PRO	pro	JJ
en-wikipedia-org-4107	2235	1217	-	-	JJ
en-wikipedia-org-4107	2235	1218	LAD	LAD	NNP
en-wikipedia-org-4107	2235	1219	Pronethalol	Pronethalol	NNP
en-wikipedia-org-4107	2235	1220	Salbutamol	Salbutamol	NNP
en-wikipedia-org-4107	2235	1221	(	(	-LRB-
en-wikipedia-org-4107	2235	1222	Levosalbutamol	Levosalbutamol	NNP
en-wikipedia-org-4107	2235	1223	)	)	-RRB-
en-wikipedia-org-4107	2235	1224	Solriamfetol	Solriamfetol	NNP
en-wikipedia-org-4107	2235	1225	Theodrenaline	Theodrenaline	NNP
en-wikipedia-org-4107	2235	1226	Thiamphenicol	Thiamphenicol	NNP
en-wikipedia-org-4107	2235	1227	UWA-101	UWA-101	NNP
en-wikipedia-org-4107	2235	1228	v	v	NN
en-wikipedia-org-4107	2235	1229	t	t	NN
en-wikipedia-org-4107	2235	1230	e	e	NNP
en-wikipedia-org-4107	2235	1231	Recreational	recreational	JJ
en-wikipedia-org-4107	2235	1232	drug	drug	NN
en-wikipedia-org-4107	2235	1233	use	use	VBP
en-wikipedia-org-4107	2235	1234	Major	major	JJ
en-wikipedia-org-4107	2235	1235	recreational	recreational	JJ
en-wikipedia-org-4107	2235	1236	drugs	drug	NNS
en-wikipedia-org-4107	2235	1237	Depressants	depressant	NNS
en-wikipedia-org-4107	2235	1238	Barbiturates	Barbiturates	NNPS
en-wikipedia-org-4107	2235	1239	Benzodiazepines	benzodiazepine	NNS
en-wikipedia-org-4107	2235	1240	Carbamates	Carbamates	NNPS
en-wikipedia-org-4107	2235	1241	Ethanol	ethanol	NN
en-wikipedia-org-4107	2235	1242	(	(	-LRB-
en-wikipedia-org-4107	2235	1243	alcohol	alcohol	NN
en-wikipedia-org-4107	2235	1244	)	)	-RRB-
en-wikipedia-org-4107	2235	1245	Alcoholic	alcoholic	JJ
en-wikipedia-org-4107	2235	1246	drinks	drink	NNS
en-wikipedia-org-4107	2235	1247	Beer	Beer	NNP
en-wikipedia-org-4107	2235	1248	Wine	Wine	NNP
en-wikipedia-org-4107	2235	1249	Gabapentinoids	Gabapentinoids	NNPS
en-wikipedia-org-4107	2235	1250	GHB	GHB	NNP
en-wikipedia-org-4107	2235	1251	Inhalants	inhalant	NNS
en-wikipedia-org-4107	2235	1252	Medical	medical	JJ
en-wikipedia-org-4107	2235	1253	Nitrous	nitrous	JJ
en-wikipedia-org-4107	2235	1254	oxide	oxide	NN
en-wikipedia-org-4107	2235	1255	Hazardous	hazardous	JJ
en-wikipedia-org-4107	2235	1256	solvents	solvent	NNS
en-wikipedia-org-4107	2235	1257	contact	contact	VBP
en-wikipedia-org-4107	2235	1258	adhesives	adhesive	NNS
en-wikipedia-org-4107	2235	1259	Gasoline	Gasoline	NNP
en-wikipedia-org-4107	2235	1260	nail	nail	NN
en-wikipedia-org-4107	2235	1261	polish	polish	NN
en-wikipedia-org-4107	2235	1262	remover	remover	NN
en-wikipedia-org-4107	2235	1263	Paint	Paint	NNP
en-wikipedia-org-4107	2235	1264	thinner	thinner	NN
en-wikipedia-org-4107	2235	1265	Other	other	JJ
en-wikipedia-org-4107	2235	1266	Freon	freon	NN
en-wikipedia-org-4107	2235	1267	Kava	Kava	NNP
en-wikipedia-org-4107	2235	1268	Nonbenzodiazepines	Nonbenzodiazepines	NNP
en-wikipedia-org-4107	2235	1269	Quinazolinones	Quinazolinones	NNPS
en-wikipedia-org-4107	2235	1270	Opioids	Opioids	NNP
en-wikipedia-org-4107	2235	1271	Buprenorphine	Buprenorphine	NNP
en-wikipedia-org-4107	2235	1272	Suboxone	Suboxone	NNP
en-wikipedia-org-4107	2235	1273	Subutex	Subutex	NNP
en-wikipedia-org-4107	2235	1274	Codeine	Codeine	NNP
en-wikipedia-org-4107	2235	1275	Desomorphine	Desomorphine	NNP
en-wikipedia-org-4107	2235	1276	Krokodil	Krokodil	NNP
en-wikipedia-org-4107	2235	1277	Dextropropoxyphene	Dextropropoxyphene	NNP
en-wikipedia-org-4107	2235	1278	Darvocet	Darvocet	NNP
en-wikipedia-org-4107	2235	1279	Darvon	Darvon	NNP
en-wikipedia-org-4107	2235	1280	Fentanyl	Fentanyl	NNP
en-wikipedia-org-4107	2235	1281	Diamorphine	Diamorphine	NNP
en-wikipedia-org-4107	2235	1282	Heroin	Heroin	NNP
en-wikipedia-org-4107	2235	1283	Hydrocodone	Hydrocodone	NNP
en-wikipedia-org-4107	2235	1284	Hydromorphone	Hydromorphone	NNP
en-wikipedia-org-4107	2235	1285	Dilaudid	Dilaudid	NNP
en-wikipedia-org-4107	2235	1286	Methadone	Methadone	NNP
en-wikipedia-org-4107	2235	1287	Mitragyna	Mitragyna	NNP
en-wikipedia-org-4107	2235	1288	speciosa	speciosa	VB
en-wikipedia-org-4107	2235	1289	Kratom	Kratom	NNP
en-wikipedia-org-4107	2235	1290	Morphine	Morphine	NNP
en-wikipedia-org-4107	2235	1291	Opium	Opium	NNP
en-wikipedia-org-4107	2235	1292	Oxycodone	Oxycodone	NNP
en-wikipedia-org-4107	2235	1293	/paracetamol	/paracetamol	,
en-wikipedia-org-4107	2235	1294	Tramadol	Tramadol	NNP
en-wikipedia-org-4107	2235	1295	Stimulants	Stimulants	NNP
en-wikipedia-org-4107	2235	1296	Amphetamine	Amphetamine	NNP
en-wikipedia-org-4107	2235	1297	Arecoline	Arecoline	NNP
en-wikipedia-org-4107	2235	1298	Areca	Areca	NNP
en-wikipedia-org-4107	2235	1299	Betel	Betel	NNP
en-wikipedia-org-4107	2235	1300	Caffeine	Caffeine	NNP
en-wikipedia-org-4107	2235	1301	Coffee	Coffee	NNP
en-wikipedia-org-4107	2235	1302	Energy	Energy	NNP
en-wikipedia-org-4107	2235	1303	drinks	drink	VBZ
en-wikipedia-org-4107	2235	1304	Tea	Tea	NNP
en-wikipedia-org-4107	2235	1305	Cathinone	Cathinone	NNP
en-wikipedia-org-4107	2235	1306	Khat	Khat	NNP
en-wikipedia-org-4107	2235	1307	Cocaine	Cocaine	NNP
en-wikipedia-org-4107	2235	1308	Coca	Coca	NNP
en-wikipedia-org-4107	2235	1309	Crack	Crack	NNP
en-wikipedia-org-4107	2235	1310	Ephedrine	Ephedrine	NNP
en-wikipedia-org-4107	2235	1311	Ephedra	Ephedra	NNP
en-wikipedia-org-4107	2235	1312	MDPV	MDPV	NNP
en-wikipedia-org-4107	2235	1313	Mephedrone	Mephedrone	NNP
en-wikipedia-org-4107	2235	1314	Methamphetamine	Methamphetamine	NNP
en-wikipedia-org-4107	2235	1315	Methylone	Methylone	NNP
en-wikipedia-org-4107	2235	1316	Methylphenidate	Methylphenidate	NNP
en-wikipedia-org-4107	2235	1317	Modafinil	Modafinil	NNP
en-wikipedia-org-4107	2235	1318	Nicotine	Nicotine	NNP
en-wikipedia-org-4107	2235	1319	Tobacco	Tobacco	NNP
en-wikipedia-org-4107	2235	1320	Theobromine	Theobromine	NNP
en-wikipedia-org-4107	2235	1321	Cocoa	Cocoa	NNP
en-wikipedia-org-4107	2235	1322	Chocolate	Chocolate	NNP
en-wikipedia-org-4107	2235	1323	Entactogens	Entactogens	NNP
en-wikipedia-org-4107	2235	1324	2C	2c	NN
en-wikipedia-org-4107	2235	1325	series	series	NN
en-wikipedia-org-4107	2235	1326	6-APB	6-APB	NNP
en-wikipedia-org-4107	2235	1327	Benzofury	Benzofury	NNP
en-wikipedia-org-4107	2235	1328	AMT	AMT	NNP
en-wikipedia-org-4107	2235	1329	MDA	MDA	NNP
en-wikipedia-org-4107	2235	1330	MDMA	mdma	NN
en-wikipedia-org-4107	2235	1331	Ecstasy	ecstasy	NN
en-wikipedia-org-4107	2235	1332	Hallucinogens	Hallucinogens	NNP
en-wikipedia-org-4107	2235	1333	Psychedelics	Psychedelics	NNPS
en-wikipedia-org-4107	2235	1334	Bufotenin	Bufotenin	NNP
en-wikipedia-org-4107	2235	1335	Psychoactive	Psychoactive	NNP
en-wikipedia-org-4107	2235	1336	toads	toad	NNS
en-wikipedia-org-4107	2235	1337	Vilca	Vilca	NNP
en-wikipedia-org-4107	2235	1338	Yopo	Yopo	NNP
en-wikipedia-org-4107	2235	1339	DMT	DMT	NNP
en-wikipedia-org-4107	2235	1340	Ayahuasca	Ayahuasca	NNP
en-wikipedia-org-4107	2235	1341	LSA	LSA	NNP
en-wikipedia-org-4107	2235	1342	LSD-25	lsd-25	CD
en-wikipedia-org-4107	2235	1343	Mescaline	mescaline	JJ
en-wikipedia-org-4107	2235	1344	Peruvian	peruvian	JJ
en-wikipedia-org-4107	2235	1345	torch	torch	NN
en-wikipedia-org-4107	2235	1346	Peyote	Peyote	NNP
en-wikipedia-org-4107	2235	1347	San	San	NNP
en-wikipedia-org-4107	2235	1348	Pedro	Pedro	NNP
en-wikipedia-org-4107	2235	1349	Psilocybin	Psilocybin	NNP
en-wikipedia-org-4107	2235	1350	/	/	SYM
en-wikipedia-org-4107	2235	1351	Psilocin	Psilocin	NNP
en-wikipedia-org-4107	2235	1352	Psilocybin	Psilocybin	NNP
en-wikipedia-org-4107	2235	1353	mushrooms	mushroom	VBZ
en-wikipedia-org-4107	2235	1354	Dissociatives	Dissociatives	NNP
en-wikipedia-org-4107	2235	1355	DXM	DXM	NNP
en-wikipedia-org-4107	2235	1356	Glaucine	Glaucine	NNP
en-wikipedia-org-4107	2235	1357	Inhalants	inhalant	VBZ
en-wikipedia-org-4107	2235	1358	Nitrous	nitrous	JJ
en-wikipedia-org-4107	2235	1359	oxide	oxide	NN
en-wikipedia-org-4107	2235	1360	alkyl	alkyl	NN
en-wikipedia-org-4107	2235	1361	nitrites	nitrite	NNS
en-wikipedia-org-4107	2235	1362	poppers	popper	VBZ
en-wikipedia-org-4107	2235	1363	amyl	amyl	VBP
en-wikipedia-org-4107	2235	1364	nitrite	nitrite	JJ
en-wikipedia-org-4107	2235	1365	Ketamine	Ketamine	NNP
en-wikipedia-org-4107	2235	1366	MXE	MXE	NNP
en-wikipedia-org-4107	2235	1367	Muscimol	Muscimol	NNP
en-wikipedia-org-4107	2235	1368	Amanita	Amanita	NNP
en-wikipedia-org-4107	2235	1369	muscaria	muscaria	NN
en-wikipedia-org-4107	2235	1370	PCP	PCP	NNP
en-wikipedia-org-4107	2235	1371	Salvinorin	Salvinorin	NNP
en-wikipedia-org-4107	2235	1372	A	A	NNP
en-wikipedia-org-4107	2235	1373	Salvia	Salvia	NNP
en-wikipedia-org-4107	2235	1374	divinorum	divinorum	NN
en-wikipedia-org-4107	2235	1375	Deliriants	Deliriants	NNP
en-wikipedia-org-4107	2235	1376	Atropine	Atropine	NNP
en-wikipedia-org-4107	2235	1377	and	and	CC
en-wikipedia-org-4107	2235	1378	Scopolamine	Scopolamine	NNP
en-wikipedia-org-4107	2235	1379	Atropa	Atropa	NNP
en-wikipedia-org-4107	2235	1380	belladonna	belladonna	NN
en-wikipedia-org-4107	2235	1381	Datura	Datura	NNP
en-wikipedia-org-4107	2235	1382	Hyoscyamus	Hyoscyamus	NNP
en-wikipedia-org-4107	2235	1383	niger	niger	NN
en-wikipedia-org-4107	2235	1384	Mandragora	Mandragora	NNP
en-wikipedia-org-4107	2235	1385	officinarum	officinarum	NNP
en-wikipedia-org-4107	2235	1386	Dimenhydrinate	Dimenhydrinate	NNP
en-wikipedia-org-4107	2235	1387	Diphenhydramine	Diphenhydramine	NNP
en-wikipedia-org-4107	2235	1388	Cannabinoids	Cannabinoids	NNPS
en-wikipedia-org-4107	2235	1389	JWH-018	JWH-018	NNP
en-wikipedia-org-4107	2235	1390	THC	THC	NNP
en-wikipedia-org-4107	2235	1391	Cannabis	Cannabis	NNP
en-wikipedia-org-4107	2235	1392	(	(	-LRB-
en-wikipedia-org-4107	2235	1393	Marijuana	Marijuana	NNP
en-wikipedia-org-4107	2235	1394	)	)	-RRB-
en-wikipedia-org-4107	2235	1395	Hashish	Hashish	NNP
en-wikipedia-org-4107	2235	1396	Hash	Hash	NNP
en-wikipedia-org-4107	2235	1397	oil	oil	NN
en-wikipedia-org-4107	2235	1398	Oneirogens	Oneirogens	NNP
en-wikipedia-org-4107	2235	1399	Calea	Calea	NNP
en-wikipedia-org-4107	2235	1400	zacatechichi	zacatechichi	NNS
en-wikipedia-org-4107	2235	1401	Silene	Silene	NNP
en-wikipedia-org-4107	2235	1402	capensis	capensis	NN
en-wikipedia-org-4107	2235	1403	Club	Club	NNP
en-wikipedia-org-4107	2235	1404	drugs	drug	VBZ
en-wikipedia-org-4107	2235	1405	Cocaine	Cocaine	NNP
en-wikipedia-org-4107	2235	1406	Quaaludes	Quaaludes	NNP
en-wikipedia-org-4107	2235	1407	MDMA	mdma	NN
en-wikipedia-org-4107	2235	1408	(	(	-LRB-
en-wikipedia-org-4107	2235	1409	Ecstasy	Ecstasy	NNP
en-wikipedia-org-4107	2235	1410	)	)	-RRB-
en-wikipedia-org-4107	2235	1411	Nitrous	nitrous	JJ
en-wikipedia-org-4107	2235	1412	oxide	oxide	NN
en-wikipedia-org-4107	2235	1413	Poppers	Poppers	NNP
en-wikipedia-org-4107	2235	1414	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1415	culture	culture	NN
en-wikipedia-org-4107	2235	1416	Cannabis	Cannabis	NNP
en-wikipedia-org-4107	2235	1417	culture	culture	NN
en-wikipedia-org-4107	2235	1418	420	420	CD
en-wikipedia-org-4107	2235	1419	Cannabis	Cannabis	NNP
en-wikipedia-org-4107	2235	1420	cultivation	cultivation	NN
en-wikipedia-org-4107	2235	1421	Cannabis	Cannabis	NNP
en-wikipedia-org-4107	2235	1422	smoking	smoke	VBG
en-wikipedia-org-4107	2235	1423	Head	Head	NNP
en-wikipedia-org-4107	2235	1424	shop	shop	NN
en-wikipedia-org-4107	2235	1425	Legal	legal	JJ
en-wikipedia-org-4107	2235	1426	history	history	NN
en-wikipedia-org-4107	2235	1427	of	of	IN
en-wikipedia-org-4107	2235	1428	cannabis	cannabis	NN
en-wikipedia-org-4107	2235	1429	in	in	IN
en-wikipedia-org-4107	2235	1430	the	the	DT
en-wikipedia-org-4107	2235	1431	United	United	NNP
en-wikipedia-org-4107	2235	1432	States	States	NNP
en-wikipedia-org-4107	2235	1433	Legality	Legality	NNP
en-wikipedia-org-4107	2235	1434	of	of	IN
en-wikipedia-org-4107	2235	1435	cannabis	cannabis	NN
en-wikipedia-org-4107	2235	1436	Marijuana	Marijuana	NNP
en-wikipedia-org-4107	2235	1437	Policy	Policy	NNP
en-wikipedia-org-4107	2235	1438	Project	Project	NNP
en-wikipedia-org-4107	2235	1439	Medical	Medical	NNP
en-wikipedia-org-4107	2235	1440	cannabis	cannabis	NN
en-wikipedia-org-4107	2235	1441	NORML	NORML	NNP
en-wikipedia-org-4107	2235	1442	Cannabis	Cannabis	NNP
en-wikipedia-org-4107	2235	1443	and	and	CC
en-wikipedia-org-4107	2235	1444	religion	religion	NN
en-wikipedia-org-4107	2235	1445	Stoner	stoner	NN
en-wikipedia-org-4107	2235	1446	film	film	NN
en-wikipedia-org-4107	2235	1447	Coffee	coffee	NN
en-wikipedia-org-4107	2235	1448	culture	culture	NN
en-wikipedia-org-4107	2235	1449	Coffee	Coffee	NNP
en-wikipedia-org-4107	2235	1450	break	break	VBP
en-wikipedia-org-4107	2235	1451	Coffeehouse	Coffeehouse	NNP
en-wikipedia-org-4107	2235	1452	Latte	Latte	NNP
en-wikipedia-org-4107	2235	1453	art	art	NN
en-wikipedia-org-4107	2235	1454	Tea	tea	NN
en-wikipedia-org-4107	2235	1455	house	house	NN
en-wikipedia-org-4107	2235	1456	Drinking	drink	VBG
en-wikipedia-org-4107	2235	1457	culture	culture	NN
en-wikipedia-org-4107	2235	1458	Bartending	Bartending	NNP
en-wikipedia-org-4107	2235	1459	Beer	Beer	NNP
en-wikipedia-org-4107	2235	1460	culture	culture	NN
en-wikipedia-org-4107	2235	1461	Beer	beer	NN
en-wikipedia-org-4107	2235	1462	festival	festival	NN
en-wikipedia-org-4107	2235	1463	Binge	Binge	NNP
en-wikipedia-org-4107	2235	1464	drinking	drink	VBG
en-wikipedia-org-4107	2235	1465	Diethyl	Diethyl	NNP
en-wikipedia-org-4107	2235	1466	ether	ether	NN
en-wikipedia-org-4107	2235	1467	Drinking	Drinking	NNP
en-wikipedia-org-4107	2235	1468	games	game	NNS
en-wikipedia-org-4107	2235	1469	Drinking	drinking	NN
en-wikipedia-org-4107	2235	1470	song	song	NN
en-wikipedia-org-4107	2235	1471	Happy	happy	JJ
en-wikipedia-org-4107	2235	1472	hour	hour	NN
en-wikipedia-org-4107	2235	1473	Hip	Hip	NNP
en-wikipedia-org-4107	2235	1474	flask	flask	NN
en-wikipedia-org-4107	2235	1475	Nightclub	Nightclub	NNP
en-wikipedia-org-4107	2235	1476	Pub	Pub	NNP
en-wikipedia-org-4107	2235	1477	Pub	Pub	NNP
en-wikipedia-org-4107	2235	1478	crawl	crawl	NN
en-wikipedia-org-4107	2235	1479	Sommelier	sommeli	JJR
en-wikipedia-org-4107	2235	1480	Sports	Sports	NNPS
en-wikipedia-org-4107	2235	1481	bar	bar	NN
en-wikipedia-org-4107	2235	1482	Tailgate	Tailgate	NNP
en-wikipedia-org-4107	2235	1483	party	party	NN
en-wikipedia-org-4107	2235	1484	Wine	wine	NN
en-wikipedia-org-4107	2235	1485	bar	bar	NN
en-wikipedia-org-4107	2235	1486	Wine	Wine	NNP
en-wikipedia-org-4107	2235	1487	tasting	taste	VBG
en-wikipedia-org-4107	2235	1488	Psychedelia	Psychedelia	NNP
en-wikipedia-org-4107	2235	1489	Psychonautics	Psychonautics	NNP
en-wikipedia-org-4107	2235	1490	Art	Art	NNP
en-wikipedia-org-4107	2235	1491	Drug	drug	NN
en-wikipedia-org-4107	2235	1492	Era	era	NN
en-wikipedia-org-4107	2235	1493	Experience	experience	NN
en-wikipedia-org-4107	2235	1494	Literature	literature	NN
en-wikipedia-org-4107	2235	1495	Music	music	NN
en-wikipedia-org-4107	2235	1496	Microdosing	Microdosing	NNP
en-wikipedia-org-4107	2235	1497	Therapy	Therapy	NNP
en-wikipedia-org-4107	2235	1498	Smoking	Smoking	NNP
en-wikipedia-org-4107	2235	1499	culture	culture	NN
en-wikipedia-org-4107	2235	1500	Cigarette	Cigarette	NNP
en-wikipedia-org-4107	2235	1501	card	card	NN
en-wikipedia-org-4107	2235	1502	Fashion	Fashion	NNP
en-wikipedia-org-4107	2235	1503	cigarettes	cigarette	VBZ
en-wikipedia-org-4107	2235	1504	Cloud	Cloud	NNP
en-wikipedia-org-4107	2235	1505	-	-	HYPH
en-wikipedia-org-4107	2235	1506	chasing	chase	VBG
en-wikipedia-org-4107	2235	1507	Loosie	Loosie	NNP
en-wikipedia-org-4107	2235	1508	Smokeasy	Smokeasy	NNP
en-wikipedia-org-4107	2235	1509	Smoking	Smoking	NNP
en-wikipedia-org-4107	2235	1510	fetishism	fetishism	NN
en-wikipedia-org-4107	2235	1511	Tobacco	Tobacco	NNP
en-wikipedia-org-4107	2235	1512	smoking	smoke	VBG
en-wikipedia-org-4107	2235	1513	Other	Other	NNP
en-wikipedia-org-4107	2235	1514	Club	Club	NNP
en-wikipedia-org-4107	2235	1515	drug	drug	NN
en-wikipedia-org-4107	2235	1516	Counterculture	Counterculture	NNP
en-wikipedia-org-4107	2235	1517	of	of	IN
en-wikipedia-org-4107	2235	1518	the	the	DT
en-wikipedia-org-4107	2235	1519	1960s	1960s	CD
en-wikipedia-org-4107	2235	1520	Dance	Dance	NNP
en-wikipedia-org-4107	2235	1521	party	party	NN
en-wikipedia-org-4107	2235	1522	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1523	paraphernalia	paraphernalia	NNP
en-wikipedia-org-4107	2235	1524	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1525	tourism	tourism	NN
en-wikipedia-org-4107	2235	1526	Entheogen	Entheogen	NNP
en-wikipedia-org-4107	2235	1527	Hippie	Hippie	NNP
en-wikipedia-org-4107	2235	1528	Needle	Needle	NNP
en-wikipedia-org-4107	2235	1529	sharing	share	VBG
en-wikipedia-org-4107	2235	1530	Nootropic	Nootropic	NNP
en-wikipedia-org-4107	2235	1531	Party	Party	NNP
en-wikipedia-org-4107	2235	1532	and	and	CC
en-wikipedia-org-4107	2235	1533	play	play	VB
en-wikipedia-org-4107	2235	1534	Poly	poly	JJ
en-wikipedia-org-4107	2235	1535	drug	drug	NN
en-wikipedia-org-4107	2235	1536	use	use	NN
en-wikipedia-org-4107	2235	1537	Rave	Rave	NNP
en-wikipedia-org-4107	2235	1538	Religion	religion	NN
en-wikipedia-org-4107	2235	1539	and	and	CC
en-wikipedia-org-4107	2235	1540	drugs	drug	VBZ
en-wikipedia-org-4107	2235	1541	Self	self	NN
en-wikipedia-org-4107	2235	1542	-	-	HYPH
en-wikipedia-org-4107	2235	1543	medication	medication	NN
en-wikipedia-org-4107	2235	1544	Sex	sex	NN
en-wikipedia-org-4107	2235	1545	and	and	CC
en-wikipedia-org-4107	2235	1546	drugs	drug	NNS
en-wikipedia-org-4107	2235	1547	Whoonga	Whoonga	NNP
en-wikipedia-org-4107	2235	1548	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1549	production	production	NN
en-wikipedia-org-4107	2235	1550	and	and	CC
en-wikipedia-org-4107	2235	1551	trade	trade	NN
en-wikipedia-org-4107	2235	1552	Drug	drug	NN
en-wikipedia-org-4107	2235	1553	production	production	NN
en-wikipedia-org-4107	2235	1554	Coca	Coca	NNP
en-wikipedia-org-4107	2235	1555	production	production	NN
en-wikipedia-org-4107	2235	1556	in	in	IN
en-wikipedia-org-4107	2235	1557	Colombia	Colombia	NNP
en-wikipedia-org-4107	2235	1558	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1559	precursors	precursor	NNS
en-wikipedia-org-4107	2235	1560	Opium	Opium	NNP
en-wikipedia-org-4107	2235	1561	production	production	NN
en-wikipedia-org-4107	2235	1562	in	in	IN
en-wikipedia-org-4107	2235	1563	Afghanistan	Afghanistan	NNP
en-wikipedia-org-4107	2235	1564	Rolling	Rolling	NNP
en-wikipedia-org-4107	2235	1565	meth	meth	NN
en-wikipedia-org-4107	2235	1566	lab	lab	NN
en-wikipedia-org-4107	2235	1567	Drug	drug	NN
en-wikipedia-org-4107	2235	1568	trade	trade	NN
en-wikipedia-org-4107	2235	1569	Illegal	illegal	JJ
en-wikipedia-org-4107	2235	1570	drug	drug	NN
en-wikipedia-org-4107	2235	1571	trade	trade	NN
en-wikipedia-org-4107	2235	1572	Colombia	Colombia	NNP
en-wikipedia-org-4107	2235	1573	Darknet	Darknet	NNP
en-wikipedia-org-4107	2235	1574	market	market	NN
en-wikipedia-org-4107	2235	1575	Drug	drug	NN
en-wikipedia-org-4107	2235	1576	distribution	distribution	NN
en-wikipedia-org-4107	2235	1577	Beer	beer	NN
en-wikipedia-org-4107	2235	1578	shop	shop	NN
en-wikipedia-org-4107	2235	1579	Cannabis	Cannabis	NNP
en-wikipedia-org-4107	2235	1580	shop	shop	NN
en-wikipedia-org-4107	2235	1581	Liquor	Liquor	NNP
en-wikipedia-org-4107	2235	1582	store	store	NN
en-wikipedia-org-4107	2235	1583	Liquor	Liquor	NNP
en-wikipedia-org-4107	2235	1584	license	license	NN
en-wikipedia-org-4107	2235	1585	Issues	issue	NNS
en-wikipedia-org-4107	2235	1586	with	with	IN
en-wikipedia-org-4107	2235	1587	drug	drug	NN
en-wikipedia-org-4107	2235	1588	use	use	NN
en-wikipedia-org-4107	2235	1589	Abuse	Abuse	NNP
en-wikipedia-org-4107	2235	1590	Date	Date	NNP
en-wikipedia-org-4107	2235	1591	rape	rape	NN
en-wikipedia-org-4107	2235	1592	drug	drug	NN
en-wikipedia-org-4107	2235	1593	Impaired	impaired	JJ
en-wikipedia-org-4107	2235	1594	driving	drive	VBG
en-wikipedia-org-4107	2235	1595	Drug	drug	NN
en-wikipedia-org-4107	2235	1596	harmfulness	harmfulness	NN
en-wikipedia-org-4107	2235	1597	Effects	Effects	NNPS
en-wikipedia-org-4107	2235	1598	of	of	IN
en-wikipedia-org-4107	2235	1599	cannabis	cannabis	NN
en-wikipedia-org-4107	2235	1600	Addiction	Addiction	NNP
en-wikipedia-org-4107	2235	1601	Dependence	Dependence	NNP
en-wikipedia-org-4107	2235	1602	Prevention	Prevention	NNP
en-wikipedia-org-4107	2235	1603	Opioid	Opioid	NNP
en-wikipedia-org-4107	2235	1604	replacement	replacement	NN
en-wikipedia-org-4107	2235	1605	therapy	therapy	NN
en-wikipedia-org-4107	2235	1606	Rehabilitation	Rehabilitation	NNP
en-wikipedia-org-4107	2235	1607	Responsible	responsible	JJ
en-wikipedia-org-4107	2235	1608	use	use	NN
en-wikipedia-org-4107	2235	1609	Drug	drug	NN
en-wikipedia-org-4107	2235	1610	-	-	HYPH
en-wikipedia-org-4107	2235	1611	related	relate	VBN
en-wikipedia-org-4107	2235	1612	crime	crime	NN
en-wikipedia-org-4107	2235	1613	Fetal	fetal	JJ
en-wikipedia-org-4107	2235	1614	alcohol	alcohol	NN
en-wikipedia-org-4107	2235	1615	spectrum	spectrum	NN
en-wikipedia-org-4107	2235	1616	disorder	disorder	NN
en-wikipedia-org-4107	2235	1617	Long	long	JJ
en-wikipedia-org-4107	2235	1618	-	-	HYPH
en-wikipedia-org-4107	2235	1619	term	term	NN
en-wikipedia-org-4107	2235	1620	effects	effect	NNS
en-wikipedia-org-4107	2235	1621	of	of	IN
en-wikipedia-org-4107	2235	1622	cannabis	cannabis	NN
en-wikipedia-org-4107	2235	1623	Neurotoxicity	Neurotoxicity	NNP
en-wikipedia-org-4107	2235	1624	Overdose	Overdose	NNP
en-wikipedia-org-4107	2235	1625	Passive	passive	JJ
en-wikipedia-org-4107	2235	1626	smoking	smoking	NN
en-wikipedia-org-4107	2235	1627	of	of	IN
en-wikipedia-org-4107	2235	1628	tobacco	tobacco	NN
en-wikipedia-org-4107	2235	1629	or	or	CC
en-wikipedia-org-4107	2235	1630	other	other	JJ
en-wikipedia-org-4107	2235	1631	substances	substance	NNS
en-wikipedia-org-4107	2235	1632	Legality	legality	NN
en-wikipedia-org-4107	2235	1633	of	of	IN
en-wikipedia-org-4107	2235	1634	drug	drug	NN
en-wikipedia-org-4107	2235	1635	use	use	VBP
en-wikipedia-org-4107	2235	1636	International	international	JJ
en-wikipedia-org-4107	2235	1637	1961	1961	CD
en-wikipedia-org-4107	2235	1638	Narcotic	Narcotic	NNP
en-wikipedia-org-4107	2235	1639	Drugs	drug	NNS
en-wikipedia-org-4107	2235	1640	1971	1971	CD
en-wikipedia-org-4107	2235	1641	Psychotropic	Psychotropic	NNP
en-wikipedia-org-4107	2235	1642	Substances	Substances	NNP
en-wikipedia-org-4107	2235	1643	1988	1988	CD
en-wikipedia-org-4107	2235	1644	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1645	Trafficking	Trafficking	NNP
en-wikipedia-org-4107	2235	1646	Council	Council	NNP
en-wikipedia-org-4107	2235	1647	of	of	IN
en-wikipedia-org-4107	2235	1648	the	the	DT
en-wikipedia-org-4107	2235	1649	European	European	NNP
en-wikipedia-org-4107	2235	1650	Union	Union	NNP
en-wikipedia-org-4107	2235	1651	decisions	decision	NNS
en-wikipedia-org-4107	2235	1652	on	on	IN
en-wikipedia-org-4107	2235	1653	designer	designer	NN
en-wikipedia-org-4107	2235	1654	drugs	drug	NNS
en-wikipedia-org-4107	2235	1655	State	state	NN
en-wikipedia-org-4107	2235	1656	level	level	NN
en-wikipedia-org-4107	2235	1657	Drug	drug	NN
en-wikipedia-org-4107	2235	1658	policy	policy	NN
en-wikipedia-org-4107	2235	1659	Decriminalization	Decriminalization	NNP
en-wikipedia-org-4107	2235	1660	Prohibition	Prohibition	NNP
en-wikipedia-org-4107	2235	1661	Supply	Supply	NNP
en-wikipedia-org-4107	2235	1662	reduction	reduction	NN
en-wikipedia-org-4107	2235	1663	Policy	policy	NN
en-wikipedia-org-4107	2235	1664	reform	reform	NN
en-wikipedia-org-4107	2235	1665	Demand	Demand	NNP
en-wikipedia-org-4107	2235	1666	reduction	reduction	NN
en-wikipedia-org-4107	2235	1667	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1668	Policy	Policy	NNP
en-wikipedia-org-4107	2235	1669	Alliance	Alliance	NNP
en-wikipedia-org-4107	2235	1670	Harm	Harm	NNP
en-wikipedia-org-4107	2235	1671	reduction	reduction	NN
en-wikipedia-org-4107	2235	1672	Law	Law	NNP
en-wikipedia-org-4107	2235	1673	Enforcement	Enforcement	NNP
en-wikipedia-org-4107	2235	1674	Action	Action	NNP
en-wikipedia-org-4107	2235	1675	Partnership	Partnership	NNP
en-wikipedia-org-4107	2235	1676	Liberalization	Liberalization	NNP
en-wikipedia-org-4107	2235	1677	Latin	Latin	NNP
en-wikipedia-org-4107	2235	1678	America	America	NNP
en-wikipedia-org-4107	2235	1679	Students	student	NNS
en-wikipedia-org-4107	2235	1680	for	for	IN
en-wikipedia-org-4107	2235	1681	Sensible	Sensible	NNP
en-wikipedia-org-4107	2235	1682	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1683	Policy	Policy	NNP
en-wikipedia-org-4107	2235	1684	Transform	Transform	NNP
en-wikipedia-org-4107	2235	1685	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1686	Policy	Policy	NNP
en-wikipedia-org-4107	2235	1687	Foundation	Foundation	NNP
en-wikipedia-org-4107	2235	1688	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1689	policy	policy	NN
en-wikipedia-org-4107	2235	1690	by	by	IN
en-wikipedia-org-4107	2235	1691	country	country	NN
en-wikipedia-org-4107	2235	1692	Australia	Australia	NNP
en-wikipedia-org-4107	2235	1693	Canada	Canada	NNP
en-wikipedia-org-4107	2235	1694	Germany	Germany	NNP
en-wikipedia-org-4107	2235	1695	India	India	NNP
en-wikipedia-org-4107	2235	1696	Netherlands	Netherlands	NNP
en-wikipedia-org-4107	2235	1697	Portugal	Portugal	NNP
en-wikipedia-org-4107	2235	1698	Slovakia	Slovakia	NNP
en-wikipedia-org-4107	2235	1699	Soviet	Soviet	NNP
en-wikipedia-org-4107	2235	1700	Union	Union	NNP
en-wikipedia-org-4107	2235	1701	Sweden	Sweden	NNP
en-wikipedia-org-4107	2235	1702	Switzerland	Switzerland	NNP
en-wikipedia-org-4107	2235	1703	United	United	NNP
en-wikipedia-org-4107	2235	1704	States	States	NNP
en-wikipedia-org-4107	2235	1705	Just	just	RB
en-wikipedia-org-4107	2235	1706	Say	say	VBP
en-wikipedia-org-4107	2235	1707	No	No	NNP
en-wikipedia-org-4107	2235	1708	Office	Office	NNP
en-wikipedia-org-4107	2235	1709	of	of	IN
en-wikipedia-org-4107	2235	1710	National	National	NNP
en-wikipedia-org-4107	2235	1711	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1712	Control	Control	NNP
en-wikipedia-org-4107	2235	1713	Policy	Policy	NNP
en-wikipedia-org-4107	2235	1714	School	School	NNP
en-wikipedia-org-4107	2235	1715	district	district	NN
en-wikipedia-org-4107	2235	1716	drug	drug	NN
en-wikipedia-org-4107	2235	1717	policies	policy	NNS
en-wikipedia-org-4107	2235	1718	California	California	NNP
en-wikipedia-org-4107	2235	1719	Colorado	Colorado	NNP
en-wikipedia-org-4107	2235	1720	Maryland	Maryland	NNP
en-wikipedia-org-4107	2235	1721	Virginia	Virginia	NNP
en-wikipedia-org-4107	2235	1722	Other	other	JJ
en-wikipedia-org-4107	2235	1723	Arguments	Arguments	NNPS
en-wikipedia-org-4107	2235	1724	for	for	IN
en-wikipedia-org-4107	2235	1725	and	and	CC
en-wikipedia-org-4107	2235	1726	against	against	IN
en-wikipedia-org-4107	2235	1727	drug	drug	NN
en-wikipedia-org-4107	2235	1728	prohibition	prohibition	NN
en-wikipedia-org-4107	2235	1729	Capital	Capital	NNP
en-wikipedia-org-4107	2235	1730	punishment	punishment	NN
en-wikipedia-org-4107	2235	1731	for	for	IN
en-wikipedia-org-4107	2235	1732	drug	drug	NN
en-wikipedia-org-4107	2235	1733	trafficking	traffic	VBG
en-wikipedia-org-4107	2235	1734	Cognitive	Cognitive	NNP
en-wikipedia-org-4107	2235	1735	liberty	liberty	NN
en-wikipedia-org-4107	2235	1736	Designer	Designer	NNP
en-wikipedia-org-4107	2235	1737	drug	drug	NN
en-wikipedia-org-4107	2235	1738	Drug	Drug	NNP
en-wikipedia-org-4107	2235	1739	court	court	NN
en-wikipedia-org-4107	2235	1740	Drug	drug	NN
en-wikipedia-org-4107	2235	1741	possession	possession	NN
en-wikipedia-org-4107	2235	1742	Drug	drug	NN
en-wikipedia-org-4107	2235	1743	test	test	NN
en-wikipedia-org-4107	2235	1744	Narc	Narc	NNP
en-wikipedia-org-4107	2235	1745	Politics	Politics	NNPS
en-wikipedia-org-4107	2235	1746	of	of	IN
en-wikipedia-org-4107	2235	1747	drug	drug	NN
en-wikipedia-org-4107	2235	1748	abuse	abuse	NN
en-wikipedia-org-4107	2235	1749	War	War	NNP
en-wikipedia-org-4107	2235	1750	on	on	IN
en-wikipedia-org-4107	2235	1751	drugs	drug	VBZ
en-wikipedia-org-4107	2235	1752	Mexican	mexican	JJ
en-wikipedia-org-4107	2235	1753	drug	drug	NN
en-wikipedia-org-4107	2235	1754	war	war	NN
en-wikipedia-org-4107	2235	1755	Plan	Plan	NNP
en-wikipedia-org-4107	2235	1756	Colombia	Colombia	NNP
en-wikipedia-org-4107	2235	1757	Philippine	philippine	JJ
en-wikipedia-org-4107	2235	1758	drug	drug	NN
en-wikipedia-org-4107	2235	1759	war	war	NN
en-wikipedia-org-4107	2235	1760	Zero	zero	CD
en-wikipedia-org-4107	2235	1761	tolerance	tolerance	NN
en-wikipedia-org-4107	2235	1762	Lists	Lists	NNPS
en-wikipedia-org-4107	2235	1763	of	of	IN
en-wikipedia-org-4107	2235	1764	countries	country	NNS
en-wikipedia-org-4107	2235	1765	by	by	IN
en-wikipedia-org-4107	2235	1766	...	...	:
en-wikipedia-org-4107	2235	1767	Alcohol	alcohol	NN
en-wikipedia-org-4107	2235	1768	legality	legality	NN
en-wikipedia-org-4107	2235	1769	Alcohol	Alcohol	NNP
en-wikipedia-org-4107	2235	1770	consumption	consumption	NN
en-wikipedia-org-4107	2235	1771	Anabolic	anabolic	JJ
en-wikipedia-org-4107	2235	1772	steroid	steroid	NN
en-wikipedia-org-4107	2235	1773	legality	legality	NN
en-wikipedia-org-4107	2235	1774	Cannabis	Cannabis	NNP
en-wikipedia-org-4107	2235	1775	legality	legality	NN
en-wikipedia-org-4107	2235	1776	Annual	annual	JJ
en-wikipedia-org-4107	2235	1777	use	use	NN
en-wikipedia-org-4107	2235	1778	Lifetime	Lifetime	NNP
en-wikipedia-org-4107	2235	1779	use	use	VBP
en-wikipedia-org-4107	2235	1780	Cigarette	Cigarette	NNP
en-wikipedia-org-4107	2235	1781	consumption	consumption	NN
en-wikipedia-org-4107	2235	1782	Cocaine	Cocaine	NNP
en-wikipedia-org-4107	2235	1783	legality	legality	NN
en-wikipedia-org-4107	2235	1784	Cocaine	Cocaine	NNP
en-wikipedia-org-4107	2235	1785	use	use	VBP
en-wikipedia-org-4107	2235	1786	Methamphetamine	methamphetamine	JJ
en-wikipedia-org-4107	2235	1787	legality	legality	NN
en-wikipedia-org-4107	2235	1788	Opiates	opiate	VBZ
en-wikipedia-org-4107	2235	1789	use	use	VBP
en-wikipedia-org-4107	2235	1790	Psilocybin	Psilocybin	NNP
en-wikipedia-org-4107	2235	1791	mushrooms	mushroom	VBZ
en-wikipedia-org-4107	2235	1792	legality	legality	NN
en-wikipedia-org-4107	2235	1793	Salvia	Salvia	NNP
en-wikipedia-org-4107	2235	1794	legality	legality	NN
en-wikipedia-org-4107	2235	1795	Medicine	Medicine	NNP
en-wikipedia-org-4107	2235	1796	portal	portal	JJ
en-wikipedia-org-4107	2235	1797	Chemistry	Chemistry	NNP
en-wikipedia-org-4107	2235	1798	portal	portal	JJ
en-wikipedia-org-4107	2235	1799	Biology	Biology	NNP
en-wikipedia-org-4107	2235	1800	portal	portal	NN
en-wikipedia-org-4107	2235	1801	Retrieved	retrieve	VBN
en-wikipedia-org-4107	2235	1802	from	from	IN
en-wikipedia-org-4107	2235	1803	"	"	``
en-wikipedia-org-4107	2235	1804	https://en.wikipedia.org/w/index.php?title=Amphetamine&oldid=992127067	https://en.wikipedia.org/w/index.php?title=amphetamine&oldid=992127067	NN
en-wikipedia-org-4107	2235	1805	"	"	''
en-wikipedia-org-4107	2235	1806	Categories	category	NNS
en-wikipedia-org-4107	2235	1807	:	:	:
en-wikipedia-org-4107	2235	1808	Amphetamine	amphetamine	VB
en-wikipedia-org-4107	2235	1809	5-HT1A	5-ht1a	CD
en-wikipedia-org-4107	2235	1810	agonists	agonist	NNS
en-wikipedia-org-4107	2235	1811	Anorectics	Anorectics	NNP
en-wikipedia-org-4107	2235	1812	Aphrodisiacs	Aphrodisiacs	NNP
en-wikipedia-org-4107	2235	1813	Carbonic	Carbonic	NNP
en-wikipedia-org-4107	2235	1814	anhydrase	anhydrase	VBP
en-wikipedia-org-4107	2235	1815	activators	activator	NNS
en-wikipedia-org-4107	2235	1816	Drugs	drug	NNS
en-wikipedia-org-4107	2235	1817	acting	act	VBG
en-wikipedia-org-4107	2235	1818	on	on	IN
en-wikipedia-org-4107	2235	1819	the	the	DT
en-wikipedia-org-4107	2235	1820	cardiovascular	cardiovascular	JJ
en-wikipedia-org-4107	2235	1821	system	system	NN
en-wikipedia-org-4107	2235	1822	Drugs	drug	NNS
en-wikipedia-org-4107	2235	1823	acting	act	VBG
en-wikipedia-org-4107	2235	1824	on	on	IN
en-wikipedia-org-4107	2235	1825	the	the	DT
en-wikipedia-org-4107	2235	1826	nervous	nervous	JJ
en-wikipedia-org-4107	2235	1827	system	system	NN
en-wikipedia-org-4107	2235	1828	Drugs	drug	NNS
en-wikipedia-org-4107	2235	1829	in	in	IN
en-wikipedia-org-4107	2235	1830	sport	sport	NN
en-wikipedia-org-4107	2235	1831	Ergogenic	Ergogenic	NNP
en-wikipedia-org-4107	2235	1832	aids	aids	NNP
en-wikipedia-org-4107	2235	1833	Euphoriants	Euphoriants	NNPS
en-wikipedia-org-4107	2235	1834	Excitatory	Excitatory	NNP
en-wikipedia-org-4107	2235	1835	amino	amino	NN
en-wikipedia-org-4107	2235	1836	acid	acid	NN
en-wikipedia-org-4107	2235	1837	reuptake	reuptake	NN
en-wikipedia-org-4107	2235	1838	inhibitors	inhibitor	NNS
en-wikipedia-org-4107	2235	1839	German	german	JJ
en-wikipedia-org-4107	2235	1840	inventions	invention	NNS
en-wikipedia-org-4107	2235	1841	Management	Management	NNP
en-wikipedia-org-4107	2235	1842	of	of	IN
en-wikipedia-org-4107	2235	1843	obesity	obesity	NN
en-wikipedia-org-4107	2235	1844	Narcolepsy	Narcolepsy	NNP
en-wikipedia-org-4107	2235	1845	Nootropics	Nootropics	NNP
en-wikipedia-org-4107	2235	1846	Norepinephrine	Norepinephrine	NNP
en-wikipedia-org-4107	2235	1847	-	-	HYPH
en-wikipedia-org-4107	2235	1848	dopamine	dopamine	NN
en-wikipedia-org-4107	2235	1849	releasing	release	VBG
en-wikipedia-org-4107	2235	1850	agents	agent	NNS
en-wikipedia-org-4107	2235	1851	Phenethylamines	Phenethylamines	NNPS
en-wikipedia-org-4107	2235	1852	Stimulants	stimulant	NNS
en-wikipedia-org-4107	2235	1853	Substituted	substitute	VBN
en-wikipedia-org-4107	2235	1854	amphetamines	amphetamine	NNS
en-wikipedia-org-4107	2235	1855	TAAR1	taar1	NN
en-wikipedia-org-4107	2235	1856	agonists	agonist	NNS
en-wikipedia-org-4107	2235	1857	Treatment	Treatment	NNP
en-wikipedia-org-4107	2235	1858	and	and	CC
en-wikipedia-org-4107	2235	1859	management	management	NN
en-wikipedia-org-4107	2235	1860	of	of	IN
en-wikipedia-org-4107	2235	1861	attention	attention	NN
en-wikipedia-org-4107	2235	1862	deficit	deficit	NN
en-wikipedia-org-4107	2235	1863	hyperactivity	hyperactivity	NN
en-wikipedia-org-4107	2235	1864	disorder	disorder	NNP
en-wikipedia-org-4107	2235	1865	VMAT	VMAT	NNP
en-wikipedia-org-4107	2235	1866	inhibitors	inhibitor	NNS
en-wikipedia-org-4107	2235	1867	World	World	NNP
en-wikipedia-org-4107	2235	1868	Anti	Anti	NNP
en-wikipedia-org-4107	2235	1869	-	-	NNP
en-wikipedia-org-4107	2235	1870	Doping	Doping	NNP
en-wikipedia-org-4107	2235	1871	Agency	Agency	NNP
en-wikipedia-org-4107	2235	1872	prohibited	prohibit	VBD
en-wikipedia-org-4107	2235	1873	substances	substance	NNS
en-wikipedia-org-4107	2235	1874	Hidden	hide	VBN
en-wikipedia-org-4107	2235	1875	categories	category	NNS
en-wikipedia-org-4107	2235	1876	:	:	:
en-wikipedia-org-4107	2235	1877	CS1	cs1	NN
en-wikipedia-org-4107	2235	1878	maint	maint	NN
en-wikipedia-org-4107	2235	1879	:	:	:
en-wikipedia-org-4107	2235	1880	DOI	doi	NN
en-wikipedia-org-4107	2235	1881	inactive	inactive	JJ
en-wikipedia-org-4107	2235	1882	as	as	IN
en-wikipedia-org-4107	2235	1883	of	of	IN
en-wikipedia-org-4107	2235	1884	November	November	NNP
en-wikipedia-org-4107	2235	1885	2020	2020	CD
en-wikipedia-org-4107	2235	1886	CS1	CS1	NNP
en-wikipedia-org-4107	2235	1887	:	:	:
en-wikipedia-org-4107	2235	1888	long	long	JJ
en-wikipedia-org-4107	2235	1889	volume	volume	NN
en-wikipedia-org-4107	2235	1890	value	value	NN
en-wikipedia-org-4107	2235	1891	CS1	CS1	NNP
en-wikipedia-org-4107	2235	1892	Japanese	japanese	JJ
en-wikipedia-org-4107	2235	1893	-	-	HYPH
en-wikipedia-org-4107	2235	1894	language	language	NN
en-wikipedia-org-4107	2235	1895	sources	source	NNS
en-wikipedia-org-4107	2235	1896	(	(	-LRB-
en-wikipedia-org-4107	2235	1897	ja	ja	NNP
en-wikipedia-org-4107	2235	1898	)	)	-RRB-
en-wikipedia-org-4107	2235	1899	Articles	article	NNS
en-wikipedia-org-4107	2235	1900	with	with	IN
en-wikipedia-org-4107	2235	1901	short	short	JJ
en-wikipedia-org-4107	2235	1902	description	description	NN
en-wikipedia-org-4107	2235	1903	Short	short	JJ
en-wikipedia-org-4107	2235	1904	description	description	NN
en-wikipedia-org-4107	2235	1905	is	be	VBZ
en-wikipedia-org-4107	2235	1906	different	different	JJ
en-wikipedia-org-4107	2235	1907	from	from	IN
en-wikipedia-org-4107	2235	1908	Wikidata	Wikidata	NNP
en-wikipedia-org-4107	2235	1909	Wikipedia	Wikipedia	NNP
en-wikipedia-org-4107	2235	1910	indefinitely	indefinitely	RB
en-wikipedia-org-4107	2235	1911	semi	semi	RB
en-wikipedia-org-4107	2235	1912	-	-	JJ
en-wikipedia-org-4107	2235	1913	protected	protect	VBN
en-wikipedia-org-4107	2235	1914	pages	page	NNS
en-wikipedia-org-4107	2235	1915	Use	Use	NNP
en-wikipedia-org-4107	2235	1916	dmy	dmy	NN
en-wikipedia-org-4107	2235	1917	dates	date	NNS
en-wikipedia-org-4107	2235	1918	from	from	IN
en-wikipedia-org-4107	2235	1919	July	July	NNP
en-wikipedia-org-4107	2235	1920	2020	2020	CD
en-wikipedia-org-4107	2235	1921	Articles	Articles	NNPS
en-wikipedia-org-4107	2235	1922	with	with	IN
en-wikipedia-org-4107	2235	1923	hAudio	hAudio	NNP
en-wikipedia-org-4107	2235	1924	microformats	microformat	VBZ
en-wikipedia-org-4107	2235	1925	Pages	Pages	NNP
en-wikipedia-org-4107	2235	1926	including	include	VBG
en-wikipedia-org-4107	2235	1927	recorded	record	VBN
en-wikipedia-org-4107	2235	1928	pronunciations	pronunciation	NNS
en-wikipedia-org-4107	2235	1929	ECHA	ECHA	NNS
en-wikipedia-org-4107	2235	1930	InfoCard	InfoCard	NNP
en-wikipedia-org-4107	2235	1931	ID	ID	NNP
en-wikipedia-org-4107	2235	1932	from	from	IN
en-wikipedia-org-4107	2235	1933	Wikidata	Wikidata	NNP
en-wikipedia-org-4107	2235	1934	Infobox	Infobox	NNP
en-wikipedia-org-4107	2235	1935	drug	drug	NN
en-wikipedia-org-4107	2235	1936	articles	article	NNS
en-wikipedia-org-4107	2235	1937	with	with	IN
en-wikipedia-org-4107	2235	1938	non	non	JJ
en-wikipedia-org-4107	2235	1939	-	-	JJ
en-wikipedia-org-4107	2235	1940	default	default	JJ
en-wikipedia-org-4107	2235	1941	infobox	infobox	NN
en-wikipedia-org-4107	2235	1942	title	title	NN
en-wikipedia-org-4107	2235	1943	Articles	article	NNS
en-wikipedia-org-4107	2235	1944	containing	contain	VBG
en-wikipedia-org-4107	2235	1945	potentially	potentially	RB
en-wikipedia-org-4107	2235	1946	dated	date	VBN
en-wikipedia-org-4107	2235	1947	statements	statement	NNS
en-wikipedia-org-4107	2235	1948	from	from	IN
en-wikipedia-org-4107	2235	1949	December	December	NNP
en-wikipedia-org-4107	2235	1950	2019	2019	CD
en-wikipedia-org-4107	2235	1951	All	all	DT
en-wikipedia-org-4107	2235	1952	articles	article	NNS
en-wikipedia-org-4107	2235	1953	containing	contain	VBG
en-wikipedia-org-4107	2235	1954	potentially	potentially	RB
en-wikipedia-org-4107	2235	1955	dated	date	VBN
en-wikipedia-org-4107	2235	1956	statements	statement	NNS
en-wikipedia-org-4107	2235	1957	Articles	Articles	NNPS
en-wikipedia-org-4107	2235	1958	containing	contain	VBG
en-wikipedia-org-4107	2235	1959	potentially	potentially	RB
en-wikipedia-org-4107	2235	1960	dated	date	VBN
en-wikipedia-org-4107	2235	1961	statements	statement	NNS
en-wikipedia-org-4107	2235	1962	from	from	IN
en-wikipedia-org-4107	2235	1963	February	February	NNP
en-wikipedia-org-4107	2235	1964	2016	2016	CD
en-wikipedia-org-4107	2235	1965	Articles	article	NNS
en-wikipedia-org-4107	2235	1966	containing	contain	VBG
en-wikipedia-org-4107	2235	1967	potentially	potentially	RB
en-wikipedia-org-4107	2235	1968	dated	date	VBN
en-wikipedia-org-4107	2235	1969	statements	statement	NNS
en-wikipedia-org-4107	2235	1970	from	from	IN
en-wikipedia-org-4107	2235	1971	2018	2018	CD
en-wikipedia-org-4107	2235	1972	PubChem	PubChem	NNP
en-wikipedia-org-4107	2235	1973	ID	ID	NNP
en-wikipedia-org-4107	2235	1974	(	(	-LRB-
en-wikipedia-org-4107	2235	1975	CID	CID	NNP
en-wikipedia-org-4107	2235	1976	)	)	-RRB-
en-wikipedia-org-4107	2235	1977	different	different	JJ
en-wikipedia-org-4107	2235	1978	from	from	IN
en-wikipedia-org-4107	2235	1979	Wikidata	Wikidata	NNP
en-wikipedia-org-4107	2235	1980	Featured	Featured	NNP
en-wikipedia-org-4107	2235	1981	articles	article	NNS
en-wikipedia-org-4107	2235	1982	Navigation	Navigation	NNP
en-wikipedia-org-4107	2235	1983	menu	menu	NN
en-wikipedia-org-4107	2235	1984	Personal	personal	JJ
en-wikipedia-org-4107	2235	1985	tools	tool	NNS
en-wikipedia-org-4107	2235	1986	Not	not	RB
en-wikipedia-org-4107	2235	1987	logged	log	VBN
en-wikipedia-org-4107	2235	1988	in	in	IN
en-wikipedia-org-4107	2235	1989	Talk	Talk	NNP
en-wikipedia-org-4107	2235	1990	Contributions	Contributions	NNP
en-wikipedia-org-4107	2235	1991	Create	Create	NNP
en-wikipedia-org-4107	2235	1992	account	account	NN
en-wikipedia-org-4107	2235	1993	Log	Log	NNP
en-wikipedia-org-4107	2235	1994	in	in	IN
en-wikipedia-org-4107	2235	1995	Namespaces	Namespaces	NNP
en-wikipedia-org-4107	2235	1996	Article	Article	NNP
en-wikipedia-org-4107	2235	1997	Talk	talk	NN
en-wikipedia-org-4107	2235	1998	Variants	variant	VBZ
en-wikipedia-org-4107	2235	1999	Views	view	NNS
en-wikipedia-org-4107	2235	2000	Read	read	VB
en-wikipedia-org-4107	2235	2001	View	View	NNP
en-wikipedia-org-4107	2235	2002	source	source	NN
en-wikipedia-org-4107	2235	2003	View	View	NNP
en-wikipedia-org-4107	2235	2004	history	history	NN
en-wikipedia-org-4107	2235	2005	More	More	JJR
en-wikipedia-org-4107	2235	2006	Search	Search	NNP
en-wikipedia-org-4107	2235	2007	Navigation	Navigation	NNP
en-wikipedia-org-4107	2235	2008	Main	Main	NNP
en-wikipedia-org-4107	2235	2009	page	page	NN
en-wikipedia-org-4107	2235	2010	Contents	content	VBZ
en-wikipedia-org-4107	2235	2011	Current	current	JJ
en-wikipedia-org-4107	2235	2012	events	event	NNS
en-wikipedia-org-4107	2235	2013	Random	random	JJ
en-wikipedia-org-4107	2235	2014	article	article	NN
en-wikipedia-org-4107	2235	2015	About	about	IN
en-wikipedia-org-4107	2235	2016	Wikipedia	Wikipedia	NNP
en-wikipedia-org-4107	2235	2017	Contact	Contact	NNP
en-wikipedia-org-4107	2235	2018	us	-PRON-	PRP
en-wikipedia-org-4107	2235	2019	Donate	Donate	NNP
en-wikipedia-org-4107	2235	2020	Contribute	contribute	NN
en-wikipedia-org-4107	2235	2021	Help	help	NN
en-wikipedia-org-4107	2235	2022	Learn	learn	VB
en-wikipedia-org-4107	2235	2023	to	to	TO
en-wikipedia-org-4107	2235	2024	edit	edit	VB
en-wikipedia-org-4107	2235	2025	Community	community	NN
en-wikipedia-org-4107	2235	2026	portal	portal	JJ
en-wikipedia-org-4107	2235	2027	Recent	recent	JJ
en-wikipedia-org-4107	2235	2028	changes	change	NNS
en-wikipedia-org-4107	2235	2029	Upload	upload	JJ
en-wikipedia-org-4107	2235	2030	file	file	NN
en-wikipedia-org-4107	2235	2031	Tools	tool	NNS
en-wikipedia-org-4107	2235	2032	What	what	WP
en-wikipedia-org-4107	2235	2033	links	link	NNS
en-wikipedia-org-4107	2235	2034	here	here	RB
en-wikipedia-org-4107	2235	2035	Related	relate	VBN
en-wikipedia-org-4107	2235	2036	changes	change	VBZ
en-wikipedia-org-4107	2235	2037	Upload	upload	JJ
en-wikipedia-org-4107	2235	2038	file	file	VBP
en-wikipedia-org-4107	2235	2039	Special	special	JJ
en-wikipedia-org-4107	2235	2040	pages	page	NNS
en-wikipedia-org-4107	2235	2041	Permanent	permanent	JJ
en-wikipedia-org-4107	2235	2042	link	link	NN
en-wikipedia-org-4107	2235	2043	Page	Page	NNP
en-wikipedia-org-4107	2235	2044	information	information	NN
en-wikipedia-org-4107	2235	2045	Cite	cite	VB
en-wikipedia-org-4107	2235	2046	this	this	DT
en-wikipedia-org-4107	2235	2047	page	page	NN
en-wikipedia-org-4107	2235	2048	Wikidata	wikidata	NN
en-wikipedia-org-4107	2235	2049	item	item	NN
en-wikipedia-org-4107	2235	2050	Print	print	NN
en-wikipedia-org-4107	2235	2051	/	/	SYM
en-wikipedia-org-4107	2235	2052	export	export	NN
en-wikipedia-org-4107	2235	2053	Download	Download	NNP
en-wikipedia-org-4107	2235	2054	as	as	IN
en-wikipedia-org-4107	2235	2055	PDF	PDF	NNP
en-wikipedia-org-4107	2235	2056	Printable	Printable	NNP
en-wikipedia-org-4107	2235	2057	version	version	NN
en-wikipedia-org-4107	2235	2058	In	in	IN
en-wikipedia-org-4107	2235	2059	other	other	JJ
en-wikipedia-org-4107	2235	2060	projects	project	NNS
en-wikipedia-org-4107	2235	2061	Wikimedia	Wikimedia	NNP
en-wikipedia-org-4107	2235	2062	Commons	Commons	NNPS
en-wikipedia-org-4107	2235	2063	Languages	Languages	NNPS
en-wikipedia-org-4107	2235	2064	العربية	العربية	NN
en-wikipedia-org-4107	2235	2065	Azərbaycanca	Azərbaycanca	NNP
en-wikipedia-org-4107	2235	2066	Bân	Bân	NNP
en-wikipedia-org-4107	2235	2067	-	-	HYPH
en-wikipedia-org-4107	2235	2068	lâm	lâm	NN
en-wikipedia-org-4107	2235	2069	-	-	HYPH
en-wikipedia-org-4107	2235	2070	gú	gú	NNP
en-wikipedia-org-4107	2235	2071	Български	Български	NNP
en-wikipedia-org-4107	2235	2072	Català	Català	NNP
en-wikipedia-org-4107	2235	2073	Čeština	Čeština	NNP
en-wikipedia-org-4107	2235	2074	Cymraeg	Cymraeg	NNP
en-wikipedia-org-4107	2235	2075	Dansk	Dansk	NNP
en-wikipedia-org-4107	2235	2076	Deutsch	Deutsch	NNP
en-wikipedia-org-4107	2235	2077	Eesti	Eesti	NNP
en-wikipedia-org-4107	2235	2078	Ελληνικά	Ελληνικά	NNP
en-wikipedia-org-4107	2235	2079	Español	Español	NNP
en-wikipedia-org-4107	2235	2080	Esperanto	Esperanto	NNP
en-wikipedia-org-4107	2235	2081	Euskara	Euskara	NNP
en-wikipedia-org-4107	2235	2082	فارسی	فارسی	JJ
en-wikipedia-org-4107	2235	2083	Føroyskt	Føroyskt	NNP
en-wikipedia-org-4107	2235	2084	Français	Français	NNP
en-wikipedia-org-4107	2235	2085	Gaeilge	Gaeilge	NNP
en-wikipedia-org-4107	2235	2086	Galego	Galego	NNP
en-wikipedia-org-4107	2235	2087	한국어	한국어	NN
en-wikipedia-org-4107	2235	2088	Հայերեն	Հայերեն	NNP
en-wikipedia-org-4107	2235	2089	Hrvatski	Hrvatski	NNP
en-wikipedia-org-4107	2235	2090	Bahasa	Bahasa	NNP
en-wikipedia-org-4107	2235	2091	Indonesia	Indonesia	NNP
en-wikipedia-org-4107	2235	2092	Íslenska	Íslenska	NNP
en-wikipedia-org-4107	2235	2093	Italiano	Italiano	NNP
en-wikipedia-org-4107	2235	2094	עברית	עברית	NN
en-wikipedia-org-4107	2235	2095	Kiswahili	Kiswahili	NNP
en-wikipedia-org-4107	2235	2096	Latviešu	Latviešu	NNP
en-wikipedia-org-4107	2235	2097	Lietuvių	Lietuvių	NNP
en-wikipedia-org-4107	2235	2098	Lingua	Lingua	NNP
en-wikipedia-org-4107	2235	2099	Franca	Franca	NNP
en-wikipedia-org-4107	2235	2100	Nova	Nova	NNP
en-wikipedia-org-4107	2235	2101	Magyar	Magyar	NNP
en-wikipedia-org-4107	2235	2102	Bahasa	Bahasa	NNP
en-wikipedia-org-4107	2235	2103	Melayu	Melayu	NNP
en-wikipedia-org-4107	2235	2104	Nederlands	Nederlands	NNP
en-wikipedia-org-4107	2235	2105	日本語	日本語	NNP
en-wikipedia-org-4107	2235	2106	Norsk	Norsk	NNP
en-wikipedia-org-4107	2235	2107	bokmål	bokmål	NN
en-wikipedia-org-4107	2235	2108	Norsk	Norsk	NNP
en-wikipedia-org-4107	2235	2109	nynorsk	nynorsk	NNP
en-wikipedia-org-4107	2235	2110	ଓଡ଼ିଆ	ଓଡ଼ିଆ	NN
en-wikipedia-org-4107	2235	2111	Polski	Polski	NNP
en-wikipedia-org-4107	2235	2112	Português	Português	NNP
en-wikipedia-org-4107	2235	2113	Română	Română	NNP
en-wikipedia-org-4107	2235	2114	Русский	Русский	NNP
en-wikipedia-org-4107	2235	2115	Scots	Scots	NNPS
en-wikipedia-org-4107	2235	2116	Simple	Simple	NNP
en-wikipedia-org-4107	2235	2117	English	English	NNP
en-wikipedia-org-4107	2235	2118	Slovenščina	Slovenščina	NNP
en-wikipedia-org-4107	2235	2119	Српски	Српски	NNP
en-wikipedia-org-4107	2235	2120	/	/	SYM
en-wikipedia-org-4107	2235	2121	srpski	srpski	JJ
en-wikipedia-org-4107	2235	2122	Srpskohrvatski	Srpskohrvatski	NNP
en-wikipedia-org-4107	2235	2123	/	/	SYM
en-wikipedia-org-4107	2235	2124	српскохрватски	српскохрватски	NN
en-wikipedia-org-4107	2235	2125	Suomi	Suomi	NNP
en-wikipedia-org-4107	2235	2126	Svenska	Svenska	NNP
en-wikipedia-org-4107	2235	2127	ไทย	ไทย	NN
en-wikipedia-org-4107	2235	2128	Türkçe	Türkçe	NNP
en-wikipedia-org-4107	2235	2129	Українська	Українська	NNP
en-wikipedia-org-4107	2235	2130	Tiếng	Tiếng	NNP
en-wikipedia-org-4107	2235	2131	Việt	Việt	NNP
en-wikipedia-org-4107	2235	2132	粵語	粵語	NNP
en-wikipedia-org-4107	2235	2133	中文	中文	NNP
en-wikipedia-org-4107	2235	2134	Edit	Edit	NNP
en-wikipedia-org-4107	2235	2135	links	link	NNS
en-wikipedia-org-4107	2235	2136	This	this	DT
en-wikipedia-org-4107	2235	2137	page	page	NN
en-wikipedia-org-4107	2235	2138	was	be	VBD
en-wikipedia-org-4107	2235	2139	last	last	RB
en-wikipedia-org-4107	2235	2140	edited	edit	VBN
en-wikipedia-org-4107	2235	2141	on	on	IN
en-wikipedia-org-4107	2235	2142	3	3	CD
en-wikipedia-org-4107	2235	2143	December	December	NNP
en-wikipedia-org-4107	2235	2144	2020	2020	CD
en-wikipedia-org-4107	2235	2145	,	,	,
en-wikipedia-org-4107	2235	2146	at	at	IN
en-wikipedia-org-4107	2235	2147	17:13	17:13	CD
en-wikipedia-org-4107	2235	2148	 	  	_SP
en-wikipedia-org-4107	2235	2149	(	(	-LRB-
en-wikipedia-org-4107	2235	2150	UTC	UTC	NNP
en-wikipedia-org-4107	2235	2151	)	)	-RRB-
en-wikipedia-org-4107	2235	2152	.	.	.
en-wikipedia-org-4107	2236	1	Text	text	NN
en-wikipedia-org-4107	2236	2	is	be	VBZ
en-wikipedia-org-4107	2236	3	available	available	JJ
en-wikipedia-org-4107	2236	4	under	under	IN
en-wikipedia-org-4107	2236	5	the	the	DT
en-wikipedia-org-4107	2236	6	Creative	Creative	NNP
en-wikipedia-org-4107	2236	7	Commons	Commons	NNP
en-wikipedia-org-4107	2236	8	Attribution	Attribution	NNP
en-wikipedia-org-4107	2236	9	-	-	HYPH
en-wikipedia-org-4107	2236	10	ShareAlike	ShareAlike	NNP
en-wikipedia-org-4107	2236	11	License	License	NNP
en-wikipedia-org-4107	2236	12	;	;	,
en-wikipedia-org-4107	2236	13	additional	additional	JJ
en-wikipedia-org-4107	2236	14	terms	term	NNS
en-wikipedia-org-4107	2236	15	may	may	MD
en-wikipedia-org-4107	2236	16	apply	apply	VB
en-wikipedia-org-4107	2236	17	.	.	.
en-wikipedia-org-4107	2237	1	By	by	IN
en-wikipedia-org-4107	2237	2	using	use	VBG
en-wikipedia-org-4107	2237	3	this	this	DT
en-wikipedia-org-4107	2237	4	site	site	NN
en-wikipedia-org-4107	2237	5	,	,	,
en-wikipedia-org-4107	2237	6	you	-PRON-	PRP
en-wikipedia-org-4107	2237	7	agree	agree	VBP
en-wikipedia-org-4107	2237	8	to	to	IN
en-wikipedia-org-4107	2237	9	the	the	DT
en-wikipedia-org-4107	2237	10	Terms	term	NNS
en-wikipedia-org-4107	2237	11	of	of	IN
en-wikipedia-org-4107	2237	12	Use	Use	NNP
en-wikipedia-org-4107	2237	13	and	and	CC
en-wikipedia-org-4107	2237	14	Privacy	Privacy	NNP
en-wikipedia-org-4107	2237	15	Policy	Policy	NNP
en-wikipedia-org-4107	2237	16	.	.	.
en-wikipedia-org-4107	2238	1	Wikipedia	Wikipedia	NNP
en-wikipedia-org-4107	2238	2	®	®	NNPS
en-wikipedia-org-4107	2238	3	is	be	VBZ
en-wikipedia-org-4107	2238	4	a	a	DT
en-wikipedia-org-4107	2238	5	registered	registered	JJ
en-wikipedia-org-4107	2238	6	trademark	trademark	NN
en-wikipedia-org-4107	2238	7	of	of	IN
en-wikipedia-org-4107	2238	8	the	the	DT
en-wikipedia-org-4107	2238	9	Wikimedia	Wikimedia	NNP
en-wikipedia-org-4107	2238	10	Foundation	Foundation	NNP
en-wikipedia-org-4107	2238	11	,	,	,
en-wikipedia-org-4107	2238	12	Inc.	Inc.	NNP
en-wikipedia-org-4107	2238	13	,	,	,
en-wikipedia-org-4107	2238	14	a	a	DT
en-wikipedia-org-4107	2238	15	non	non	JJ
en-wikipedia-org-4107	2238	16	-	-	JJ
en-wikipedia-org-4107	2238	17	profit	profit	JJ
en-wikipedia-org-4107	2238	18	organization	organization	NN
en-wikipedia-org-4107	2238	19	.	.	.
en-wikipedia-org-4107	2239	1	Privacy	privacy	NN
en-wikipedia-org-4107	2239	2	policy	policy	NN
en-wikipedia-org-4107	2239	3	About	about	IN
en-wikipedia-org-4107	2239	4	Wikipedia	Wikipedia	NNP
en-wikipedia-org-4107	2239	5	Disclaimers	Disclaimers	NNPS
en-wikipedia-org-4107	2239	6	Contact	Contact	NNP
en-wikipedia-org-4107	2239	7	Wikipedia	Wikipedia	NNP
en-wikipedia-org-4107	2239	8	Mobile	Mobile	NNP
en-wikipedia-org-4107	2239	9	view	view	NN
en-wikipedia-org-4107	2239	10	Developers	Developers	NNP
en-wikipedia-org-4107	2239	11	Statistics	Statistics	NNP
en-wikipedia-org-4107	2239	12	Cookie	Cookie	NNP
en-wikipedia-org-4107	2239	13	statement	statement	NN